Dermatology: Practical and Conceptual DERMATOLOGY PRACTICAL & CONCEPTUAL www.derm101.com Observation | Dermatol Pract Concept 2012;3(2):6 49 Introduction The diagnosis of melanomas smaller than 4 mm presents dif- ficulties because the clinical and dermatoscopic features of small melanomas have been reported infrequently. Case report A 38-year-old Australian-born woman of Italian descent, with Fitzpatrick type 4 skin, presented for a routine yearly skin examination. She was examined with a Heine Delta 20 dermatoscope (Heine, Optotechnic GmbH, Herrsching, Germany) and had been having total body photography with a Molemax Dermdoc video monitoring system (Derma Medical Systems, Austria). In previous years some pigmented lesions (PSLs) had been observed to change with symmet- rical growth of peripheral clods. These were deemed to be maturing nevi and had not been excised. One pigmented skin lesion had been excised in 2007 and was reported by the pathologist to be an irritated dysplastic nevus. At this visit in May 2012, a new lesion was detected on the left arm (Figure 1A). Clinically it was noted to be darker than surrounding PSLs and dermatoscopically pseudopods and radial lines were arranged circumferentially around a A tiny invasive melanoma: a case report with dermatoscopy and dermatopathology Gary Pellizzari, MBBS1, Jill Magee M.D.2, David Weedon, M.D.3, Cliff Rosendahl, MBBS4 1 Nepean Family Medical Centre and Skin Detective, Victoria, Australia 2 Dorevitch Pathology, Heidelberg, Australia 3 Sullivan Nicolaides Pathology, Brisbane, Australia 4 School of Medicine, The University of Queensland, Brisbane, Australia Key words: melanoma, small melanoma, dermatoscopy, dermoscopy, dermatopathology Citation: Pellizzari G, Magee J, Weedon D, Rosendahl C. A tiny invasive melanoma: a case report with dermatoscopy and dermatopathology. Dermatol Pract Conc. 2013;3(2):6. http://dx.doi.org/10.5826/dpc.0302a06. Received: November 2, 2012; Accepted: January 31, 2013; Published: April 30, 2013 Copyright: ©2013 Pellizzari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: None. Competing interests: The authors have no conflicts of interest to disclose. All authors have contributed significantly to this publication. Corresponding author: Cliff Rosendahl, PO Box 734, Capalaba, Queensland, 4157, Australia. Tel. 61 7 3245 3011; Fax. 61 7 3245 3022. Email: cliffrosendahl@bigpond.com. We present a case of an early invasive melanoma (Breslow thickness 0.25 mm), 1.6 mm in diameter on the arm of a 38-year-old woman. She was under surveillance due to having multiple (>100) nevi, and the melanoma was assessed as a new lesion by the examining doctor. Clinically the lesion was hyper- pigmented compared with surrounding nevi and dermatoscopically it had a clue of pseudopods/lines radial, but they were arranged in an arguably symmetrical circumferential pattern around a structure- less blue-gray center. Generally melanomas are expected to be dermatoscopically asymmetrical, but we believe that this case illustrates the fact that small melanomas may be recognized by clues such as pseudopods/lines radial and dermatoscopic gray even when they have not yet developed unequivocal asymmetry. ABSTRACT 50 Observation | Dermatol Pract Concept 2012;3(2):6 structureless blue-gray center (Figure 1B); the radial lines were arguably symmetrically distributed, appearing in all quadrants of the perimeter while being less clearly defined and sparser in one quadrant. This lesion was new at mature age (evolving), which raised suspicion for malignancy despite the lesion’s small size and equivocal symmetry [1]. The lesion was subjected to excision biopsy and dermatopathologic assessment (Figure 2 composite) showed a small, but asym- metric, nested and single cell proliferation of atypical mela- Figure 1. (A) Clinical image and (B) dermatoscopic image of a new pigmented skin lesion on the arm of a 38-year-old woman. Radial lines/pseudopods are arranged circumferentially around a structure- less blue-gray centre. Although radial lines/pseudopods are present in all quadrants of the periphery they are less numerous in the up- per-left quadrant. Asymmetry is assessed as equivocal. [Copyright: ©2013 Pellizzari et al.] nocytes along the dermoepidermal junction with scattered single cell intraepithelial upward spread. There was limited extension into the papillary dermis to a depth of 0.25 mm. Superficial dermal melanosis and inflammation were pres- ent along with mild fibroplasia, suggesting a component of regression to a depth of 0.35 mm. In spite of the dermato- scopic appearance of lines radial circumferential, there were no spitzoid features dermatopathologically. The diagnosis of early level 2 malignant melanoma of superficial spreading type was rendered. Physical examination revealed no evi- dence of lymphatic or systemic metastasis and the patient will have routine clinical and dermatoscopic surveillance in accordance with current guidelines [2]. Discussion A proportion of melanomas have been found not to fit the D criterion of the ABCD acronym, where D stands for a diameter of 6 mm or greater. Such small melanomas have a reported frequency of 11.4-38.2% of all melanomas [3-6]. One review in particular, published in 2004, found that small melanomas include less than 1 to 38% of all invasive mela- nomas [1] and it recommended that the ABCD acronym be modified to ABCDE with “E” to stand for “evolving.” Previously the dermatoscopic features of an in-situ mela- noma with a diameter of 1.6 mm were reported [7]. Published dermatoscopy images revealed that even at this minute size there was unequivocal asymmetry of structure and the pres- ence of the dermatoscopic clue to melanoma of gray dots. It satisfied the criteria for malig- nancy of the 3-point checklist [8], the Menzies method [9] and Chaos and Clues [10]. Teng et al reported the dermatoscopic features of an in-situ melanoma with a diameter of 2 mm [11]. A published derma- toscopy image revealed unequivo- cal asymmetry of both color and structure with some lines radial segmental and blue-gray structures. In the case that we report, the lesion was noted to be hyperpig- mented compared to surrounding PSLs. One previous study reported that intensity of dark pigmentation was the defining clinical charac- teristic in each of 13 (including 5 invasive) small melanomas (<4 mm diameter) in a series of 95 melano- mas [5], although this may in fact be due to selection bias as minute dark melanomas are more likely to be noticed and assessed in compari- Figure 2. (A) Low power and (B, C) high power dermatopathologic images of the lesion shown in Figure 1. [Copyright: ©2013 Pellizzari et al.] Observation | Dermatol Pract Concept 2012;3(2):6 51 son to small pale melanomas which may be present but not detected. The case reported here, unlike the two previously reported smallest in-situ melanomas [7,11] did not exhibit unequivocal dermatoscopic asymmetry, and this is significant because dermatoscopic asymmetry is a generally accepted criterion for all of the published clinical and dermatoscopic algorithms. However in one study of consecutive pigmented skin lesions with a maximum diameter of 6mm (range 3-6 mm) excised in a specialized university dermatology depart- ment over four years, 34 out of a total of 103 melanocytic lesions were melanomas [12], and of those 34 melanomas only 11 (32.4%) were asymmetrical. This supports the need to assess small PSLs without the required algorithmic crite- rion of asymmetry. In one pilot study of 28 diagnosed melanomas less than or equal to 4 mm in diameter, there were only 14 (50%) that were unanimously diagnosed as melanomas by each of three dermatopathologists [13]. The dermatopathologic criteria of these were evaluated. The criteria regarded as most sig- nificant included pagetoid spread (n=9/14), irregular nesting (n=9/14), predominance of individual junctional melanocytes (n=6/14) and cytological atypia (n=13/14). The very small melanoma we present in this case report exhibited all of these features as well as poor maturation in the invasive portion with pigmentation and nesting to the base of the lesion. Conclusion The melanoma reported here had the same diameter, of 1.6 mm, as the previously smallest reported melanoma with dermatoscopic images, but it differed in that it was inva- sive. As has been previously reported with small melanomas, it was darker than surrounding nevi but this may be due to selection bias. We regard it as very significant that this melanoma did not have unequivocal asymmetry, although it did have recognized clues to malignancy, including the presence of gray color and radial lines/pseudopods, albeit arranged in a circumferential pattern. We believe that very small pigmented lesions which have any recognized clues to melanoma should be assessed for biopsy whether or not unequivocal asymmetry is present. References 1. Abbasi NR, Shaw HM, Rigel DS, et al. 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