id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dpc-237	Bari, Omar; Cohen, Philip R.	Eosinophilic dermatosis of hematologic malignancy mimicking varicella zoster infection: report in a woman with chronic lymphocytic leukemia and review of the literature	2017	10	.pdf	application/pdf	4279	216	36	Summary of eosinophilic dermatosis of hematologic malignancy [Copyright: ©2017 Bari et al.] Author, Year Number of Cases Associated Malignancy Age; Sex Clinical Manifestation Histology Management EDHM Course Ref Weed, 1965 8 CLL 40-76; NR Erythematous, indurated, and pruritic lesions in areas of recent mosquito bites or areas with central punctum Subepidermal edema with dense dermal infiltrate of eosinophils and lymphocytes CLL was treated with chlorambucil or prednisone in most patients Lesions resolved spontaneously within weeks 1 Rosen, 1986 10 CLL 57-82; 7 M, 3 W Erythematous and pruritic bullae, nodules, and papules at various locations Superficial and deep, perivascular, periadnexal, and interstitial infiltrate of eosinophils and lymphocytes Treatments for CLL included prednisone, vincristine, cyclophosphamide, and chlorambucil NR 11 Kolbusz, 1989 1 CLL 51; W Recurrent eruptions of erythematous urticarial patches on the extremities and trunk Lymphohistiocytic infiltrate with eosinophils Diphenhydramine for skin lesions Initial outbreaks were self-limited with no treatment; later eruptions improved with diphenhydramine 12 Davis, 1998 8 CLL 51-69; 6 M, 2 W Papular and vesiculobullous lesions in various locations All biopsies revealed lymphohistioctic infiltrate and eosinophils in the dermis Chemotherapy, IVIG, and glucocorticoids 3 patients experienced improvement with chemotherapy for CLL; 1 patient improved with IVIG; 4 patients responded to oral glucocorticoids 10 Barzilai, 1999 8 ALL, AML, CLL (3 patients), MCL, LCL, MF 42-72; 4 M, 4 W Recurrent erythematous, pruritic papules and plaques at various locations Superficial and deep perivascular and interstitial infiltrate of eosinophils and lymphocytes Topical antipruritic agents, topical and systemic corticosteroids, systemic antihistamines No improvement with any agent except systemic corticosteroids, though lesions recurred when steroids were tapered 2 Blum, 2001 1 CLL 49; M Admitted to the hos pi tal after second cycle of chemotherapy with vesicles and hemorrhagic bullae on the extremities, face, and trunk Superficial and deep perivascular dermatitis with interstitial eosinophils Systemic corticosteroids Lesions improved with steroids but recurred with tapered dose 13 Byrd, 2001 4 AML, CLL (2 patients), MDS 53-81; 4 M Recurrent eruptions of erythematous, pruritic nodules and papules at various locations Perivascular and periadnexal infiltrate with lymphocytes and eosinophils Antibiotics, antifungals, antihistamines, colchicine, dapsone, hydroxyurea, hydroxychloroquine, isotretinoin, systemic and topical steroids, and UV-B phototherapy for skin lesions; chemotherapy started for malignancy 2 patients’ lesions resolved during chemotherapy but recurred once it was complete, and chemotherapy was re-started to control skin lesions in these patients; 2 patients experienced improvement with phototherapy 3 Asakura, 2004 1 CLL 46; W Pruritic, erythematous bullae on the extremities in the site of prior mosquito bites NR Cyclophosphamide and prednisolone for CLL Skin lesions were self-limited 14 Cocuroccia, 2004 Author, Year Number of Cases Associated Malignancy Age; Sex Clinical Manifestation Histology Management EDHM Course Ref Bari and Cohen, 2017 1 CLL 59; W 5-year history of dermatomal and non-dermatomal distribution of vesicles on the back and flanks Eosinophilic spongiosis, intraepidermal vesicle with eosinophils, and perivascular and periadnexal lymphocytic infiltrate with eosinophils Acyclovir, topical betamethasone for skin lesions; CLL was treated with many agents but most recently the patient was started on obinutuzumab Acyclovir was not efficacious, though topical betamethasone led to temporary resolution of skin lesions; patient experienced fewer recurrences after obinutuzumab was started CR Abbreviations: ALL, acute lymphocytic leukemia; AML, acute monocytic leukemia; CHOP, cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone; CLL, chronic lymphocytic leukemia; CR, current report; DLBCL, diffuse large B cell lymphoma; EDHM, eosinophilic dermatosis of hematologic malignancy; IVIG, intrave- nous immunoglobulin; LCL, large cell lymphoma; M, man; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MF, myelofibrosis; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; NMZL, nodal marginal zone lymphoma; NR, not reported; Ref, reference; UV-B, ultraviolet-B phototherapy; W, woman TABLE 1.	cache/dpc-237.pdf	txt/dpc-237.txt