id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dpc-5172	Huang, Hsin-Yin; Lee, Leon Tsung-Ju	Tretinoin for Photodamaged Facial Skin: Systematic Review and Meta-Analysis of Randomized Controlled Trials	2025	10	.pdf	application/pdf	6703	415	54	Eligibility Criteria: Inclusion and Exclusion Criteria The inclusion criteria for the trials were as follows: i) ran- domized, vehicle-controlled design; ii) use of tretinoin in a single formulation with variations in dosage, base, and appli- cation method as the primary treatment for photoaging; iii) evaluation of tretinoin’s effects on facial skin wrinkles (fine wrinkles, coarse wrinkles, or both), with results reported as percentage improvements in wrinkle appearance; iv) inclu- sion of participants aged 18 years or older with mild, moder- ate, or severe skin photodamage. Forest plot illustrating the effects of topical tretinoin on coarse wrinkles in photodamaged facial skin compared with placebo (vehicle).	cache/dpc-5172.pdf	txt/dpc-5172.txt