id sid tid token lemma pos dpc-1428 1 1 dermatology dermatology NOUN dpc-1428 1 2 : : PUNCT dpc-1428 1 3 practical practical ADJ dpc-1428 1 4 and and CCONJ dpc-1428 1 5 conceptual conceptual ADJ dpc-1428 1 6 letter letter NOUN dpc-1428 2 1 | | ADV dpc-1428 2 2 dermatol dermatol ADJ dpc-1428 2 3 pract pract NOUN dpc-1428 2 4 concept concept NOUN dpc-1428 2 5 2021;11(2):e2021011 2021;11(2):e2021011 NUM dpc-1428 2 6 1 1 NUM dpc-1428 2 7 dermatology dermatology NOUN dpc-1428 2 8 practical practical ADJ dpc-1428 2 9 & & CCONJ dpc-1428 2 10 conceptual conceptual ADJ dpc-1428 2 11 usefulness usefulness NOUN dpc-1428 2 12 of of ADP dpc-1428 2 13 topical topical ADJ dpc-1428 2 14 imiquimod imiquimod ADJ dpc-1428 2 15 3.75 3.75 NUM dpc-1428 2 16 % % NOUN dpc-1428 2 17 in in ADP dpc-1428 2 18 cytokeratin cytokeratin NOUN dpc-1428 2 19 7 7 NUM dpc-1428 2 20 positive positive ADJ dpc-1428 2 21 extramammary extramammary NOUN dpc-1428 2 22 paget paget NOUN dpc-1428 2 23 disease disease NOUN dpc-1428 2 24 of of ADP dpc-1428 2 25 the the DET dpc-1428 2 26 vulva vulva NOUN dpc-1428 2 27 : : PUNCT dpc-1428 2 28 towards towards ADP dpc-1428 2 29 personalized personalized ADJ dpc-1428 2 30 therapy therapy NOUN dpc-1428 2 31 sara sara PROPN dpc-1428 2 32 mazzilli1 mazzilli1 PROPN dpc-1428 2 33 , , PUNCT dpc-1428 2 34 annunziata annunziata VERB dpc-1428 2 35 dattola1 dattola1 PROPN dpc-1428 2 36 , , PUNCT dpc-1428 2 37 anna anna PROPN dpc-1428 2 38 angela angela PROPN dpc-1428 2 39 criscuolo2 criscuolo2 PROPN dpc-1428 2 40 , , PUNCT dpc-1428 2 41 terenzio terenzio NOUN dpc-1428 2 42 cosio1 cosio1 PROPN dpc-1428 2 43 , , PUNCT dpc-1428 2 44 luca luca PROPN dpc-1428 2 45 bianchi1 bianchi1 PROPN dpc-1428 2 46 , , PUNCT dpc-1428 2 47 elena elena PROPN dpc-1428 2 48 campione1 campione1 PROPN dpc-1428 2 49 , , PUNCT dpc-1428 2 50 monia monia PROPN dpc-1428 2 51 di di PROPN dpc-1428 2 52 prete3 prete3 PROPN dpc-1428 2 53 , , PUNCT dpc-1428 2 54 elisabetta elisabetta PROPN dpc-1428 2 55 botti2 botti2 PROPN dpc-1428 2 56     SPACE dpc-1428 2 57 1 1 NUM dpc-1428 2 58 dermatology dermatology NOUN dpc-1428 2 59 unit unit NOUN dpc-1428 2 60 , , PUNCT dpc-1428 2 61 department department NOUN dpc-1428 2 62 of of ADP dpc-1428 2 63 systems system NOUN dpc-1428 2 64 medicine medicine NOUN dpc-1428 2 65 , , PUNCT dpc-1428 2 66 university university NOUN dpc-1428 2 67 of of ADP dpc-1428 2 68 rome rome PROPN dpc-1428 2 69 tor tor PROPN dpc-1428 2 70 vergata vergata PROPN dpc-1428 2 71 , , PUNCT dpc-1428 2 72 italy italy PROPN dpc-1428 2 73     SPACE dpc-1428 2 74 2 2 NUM dpc-1428 2 75 department department NOUN dpc-1428 2 76 of of ADP dpc-1428 2 77 gynecology gynecology NOUN dpc-1428 2 78 , , PUNCT dpc-1428 2 79 university university NOUN dpc-1428 2 80 of of ADP dpc-1428 2 81 rome rome PROPN dpc-1428 2 82 tor tor PROPN dpc-1428 2 83 vergata vergata PROPN dpc-1428 2 84 , , PUNCT dpc-1428 2 85 italy italy PROPN dpc-1428 2 86     SPACE dpc-1428 2 87 3 3 NUM dpc-1428 2 88 anatomical anatomical ADJ dpc-1428 2 89 pathology pathology NOUN dpc-1428 2 90 , , PUNCT dpc-1428 2 91 university university PROPN dpc-1428 2 92 of of ADP dpc-1428 2 93 rome rome PROPN dpc-1428 2 94 tor tor PROPN dpc-1428 2 95 vergata vergata PROPN dpc-1428 2 96 , , PUNCT dpc-1428 2 97 italy italy PROPN dpc-1428 2 98     SPACE dpc-1428 2 99 key key ADJ dpc-1428 2 100 words word NOUN dpc-1428 2 101 : : PUNCT dpc-1428 2 102 imiquimod imiquimod ADJ dpc-1428 2 103 , , PUNCT dpc-1428 2 104 extramammary extramammary ADJ dpc-1428 2 105 paget paget PROPN dpc-1428 2 106 disease disease PROPN dpc-1428 2 107 , , PUNCT dpc-1428 2 108 vulva vulva PROPN dpc-1428 2 109 , , PUNCT dpc-1428 2 110 cytokeratin cytokeratin NOUN dpc-1428 2 111 7 7 NUM dpc-1428 2 112 citation citation NOUN dpc-1428 2 113 : : PUNCT dpc-1428 3 1 usefulness usefulness NOUN dpc-1428 3 2 of of ADP dpc-1428 3 3 topical topical ADJ dpc-1428 3 4 imiquimod imiquimod ADJ dpc-1428 3 5 3.75 3.75 NUM dpc-1428 3 6 % % NOUN dpc-1428 3 7 in in ADP dpc-1428 3 8 cytokeratin cytokeratin NOUN dpc-1428 3 9 7 7 NUM dpc-1428 3 10 positive positive ADJ dpc-1428 3 11 extramammary extramammary NOUN dpc-1428 3 12 paget paget NOUN dpc-1428 3 13 disease disease NOUN dpc-1428 3 14 of of ADP dpc-1428 3 15 the the DET dpc-1428 3 16 vulva vulva NOUN dpc-1428 3 17 : : PUNCT dpc-1428 3 18 towards towards ADP dpc-1428 3 19 personalized personalized ADJ dpc-1428 3 20 therapy therapy NOUN dpc-1428 3 21 . . PUNCT dpc-1428 4 1 dermatol dermatol NOUN dpc-1428 4 2 pract pract PROPN dpc-1428 4 3 concept concept NOUN dpc-1428 4 4 . . PUNCT dpc-1428 5 1 2021;11(2):e2021011 2021;11(2):e2021011 X dpc-1428 5 2 . . X dpc-1428 6 1 doi doi NOUN dpc-1428 6 2 : : PUNCT dpc-1428 6 3 https://doi.org/10.5826/dpc.1102a11 https://doi.org/10.5826/dpc.1102a11 ADV dpc-1428 6 4 accepted accept VERB dpc-1428 6 5 : : PUNCT dpc-1428 6 6 august august PROPN dpc-1428 6 7 8 8 NUM dpc-1428 6 8 , , PUNCT dpc-1428 6 9 2020 2020 NUM dpc-1428 6 10 ; ; PUNCT dpc-1428 6 11 published publish VERB dpc-1428 6 12 : : PUNCT dpc-1428 6 13 march march PROPN dpc-1428 6 14 8 8 NUM dpc-1428 6 15 , , PUNCT dpc-1428 6 16 2021 2021 NUM dpc-1428 6 17 copyright copyright NOUN dpc-1428 6 18 : : PUNCT dpc-1428 7 1 © © PROPN dpc-1428 7 2 2021 2021 NUM dpc-1428 7 3 mazzilli mazzilli PROPN dpc-1428 7 4 et et PROPN dpc-1428 7 5 al al PROPN dpc-1428 7 6 . . PUNCT dpc-1428 8 1 this this PRON dpc-1428 8 2 is be AUX dpc-1428 8 3 an an DET dpc-1428 8 4 open open ADJ dpc-1428 8 5 - - PUNCT dpc-1428 8 6 access access NOUN dpc-1428 8 7 article article NOUN dpc-1428 8 8 distributed distribute VERB dpc-1428 8 9 under under ADP dpc-1428 8 10 the the DET dpc-1428 8 11 terms term NOUN dpc-1428 8 12 of of ADP dpc-1428 8 13 the the DET dpc-1428 8 14 creative creative ADJ dpc-1428 8 15 commons common NOUN dpc-1428 8 16 attribution attribution NOUN dpc-1428 8 17 license license NOUN dpc-1428 8 18 by by ADP dpc-1428 8 19 - - PUNCT dpc-1428 8 20 nc-4.0 nc-4.0 NOUN dpc-1428 8 21 , , PUNCT dpc-1428 8 22 which which PRON dpc-1428 8 23 permits permit VERB dpc-1428 8 24 unrestricted unrestricted ADJ dpc-1428 8 25 noncommercial noncommercial ADJ dpc-1428 8 26 use use NOUN dpc-1428 8 27 , , PUNCT dpc-1428 8 28 distribution distribution NOUN dpc-1428 8 29 , , PUNCT dpc-1428 8 30 and and CCONJ dpc-1428 8 31 reproduction reproduction NOUN dpc-1428 8 32 in in ADP dpc-1428 8 33 any any DET dpc-1428 8 34 medium medium NOUN dpc-1428 8 35 , , PUNCT dpc-1428 8 36 provided provide VERB dpc-1428 8 37 the the DET dpc-1428 8 38 original original ADJ dpc-1428 8 39 author author NOUN dpc-1428 8 40 and and CCONJ dpc-1428 8 41 source source NOUN dpc-1428 8 42 are be AUX dpc-1428 8 43 credited credit VERB dpc-1428 8 44 . . PUNCT dpc-1428 9 1 funding funding NOUN dpc-1428 9 2 : : PUNCT dpc-1428 9 3 none none NOUN dpc-1428 9 4 . . PUNCT dpc-1428 10 1 competing compete VERB dpc-1428 10 2 interests interest NOUN dpc-1428 10 3 : : PUNCT dpc-1428 10 4 the the DET dpc-1428 10 5 authors author NOUN dpc-1428 10 6 have have VERB dpc-1428 10 7 no no DET dpc-1428 10 8 conflicts conflict NOUN dpc-1428 10 9 of of ADP dpc-1428 10 10 interest interest NOUN dpc-1428 10 11 to to PART dpc-1428 10 12 disclose disclose VERB dpc-1428 10 13 . . PUNCT dpc-1428 11 1 authorship authorship NOUN dpc-1428 11 2 : : PUNCT dpc-1428 11 3 all all DET dpc-1428 11 4 authors author NOUN dpc-1428 11 5 have have AUX dpc-1428 11 6 contributed contribute VERB dpc-1428 11 7 significantly significantly ADV dpc-1428 11 8 to to ADP dpc-1428 11 9 this this DET dpc-1428 11 10 publication publication NOUN dpc-1428 11 11 . . PUNCT dpc-1428 12 1 corresponding correspond VERB dpc-1428 12 2 author author NOUN dpc-1428 12 3 : : PUNCT dpc-1428 12 4 sara sara PROPN dpc-1428 12 5 mazzilli mazzilli PROPN dpc-1428 12 6 , , PUNCT dpc-1428 12 7 md md PROPN dpc-1428 12 8 , , PUNCT dpc-1428 12 9 dermatologic dermatologic ADJ dpc-1428 12 10 unit unit NOUN dpc-1428 12 11 , , PUNCT dpc-1428 12 12 department department NOUN dpc-1428 12 13 of of ADP dpc-1428 12 14 systems system NOUN dpc-1428 12 15 medicine medicine NOUN dpc-1428 12 16 , , PUNCT dpc-1428 12 17     SPACE dpc-1428 12 18 university university NOUN dpc-1428 12 19 of of ADP dpc-1428 12 20 rome rome PROPN dpc-1428 12 21 tor tor PROPN dpc-1428 12 22 vergata vergata PROPN dpc-1428 12 23 , , PUNCT dpc-1428 12 24 00133 00133 NUM dpc-1428 12 25 rome rome PROPN dpc-1428 12 26 , , PUNCT dpc-1428 12 27 italy italy PROPN dpc-1428 12 28 . . PUNCT dpc-1428 13 1 email email NOUN dpc-1428 13 2 : : PUNCT dpc-1428 13 3 saramazzilli2@gmail.com saramazzilli2@gmail.com X dpc-1428 13 4 introduction introduction NOUN dpc-1428 13 5 extramammary extramammary PROPN dpc-1428 13 6 paget paget PROPN dpc-1428 13 7 disease disease NOUN dpc-1428 13 8 ( ( PUNCT dpc-1428 13 9 empd empd NOUN dpc-1428 13 10 ) ) PUNCT dpc-1428 13 11 of of ADP dpc-1428 13 12 the the DET dpc-1428 13 13 vulva vulva NOUN dpc-1428 13 14 , , PUNCT dpc-1428 13 15 a a DET dpc-1428 13 16 rare rare ADJ dpc-1428 13 17 adenocarcinoma adenocarcinoma NOUN dpc-1428 13 18 in in ADP dpc-1428 13 19 situ situ NOUN dpc-1428 13 20 , , PUNCT dpc-1428 13 21 is be AUX dpc-1428 13 22 often often ADV dpc-1428 13 23 resected resect VERB dpc-1428 13 24 with with ADP dpc-1428 13 25 involved involved ADJ dpc-1428 13 26 margins margin NOUN dpc-1428 13 27 . . PUNCT dpc-1428 14 1 the the DET dpc-1428 14 2 clinical clinical ADJ dpc-1428 14 3 presentation presentation NOUN dpc-1428 14 4 presents present VERB dpc-1428 14 5 with with ADP dpc-1428 14 6 erythematous erythematous ADJ dpc-1428 14 7 plaques plaque NOUN dpc-1428 14 8 of of ADP dpc-1428 14 9 sluggish sluggish ADJ dpc-1428 14 10 growth growth NOUN dpc-1428 14 11 , , PUNCT dpc-1428 14 12 well well ADV dpc-1428 14 13 - - PUNCT dpc-1428 14 14 defined define VERB dpc-1428 14 15 edges edge NOUN dpc-1428 14 16 , , PUNCT dpc-1428 14 17 fine fine ADJ dpc-1428 14 18 scaling scaling NOUN dpc-1428 14 19 , , PUNCT dpc-1428 14 20 excoriations excoriation NOUN dpc-1428 14 21 , , PUNCT dpc-1428 14 22 ulcerations ulceration NOUN dpc-1428 14 23 , , PUNCT dpc-1428 14 24 and and CCONJ dpc-1428 14 25 lichenification lichenification NOUN dpc-1428 14 26 . . PUNCT dpc-1428 15 1 empd empd PROPN dpc-1428 15 2 can can AUX dpc-1428 15 3 manifest manifest VERB dpc-1428 15 4 as as ADP dpc-1428 15 5 a a DET dpc-1428 15 6 single single ADJ dpc-1428 15 7 whitish whitish NOUN dpc-1428 15 8 or or CCONJ dpc-1428 15 9 confluent confluent ADJ dpc-1428 15 10 , , PUNCT dpc-1428 15 11 sometimes sometimes ADV dpc-1428 15 12 ulcerated ulcerated ADJ dpc-1428 15 13 lesion lesion NOUN dpc-1428 15 14 . . PUNCT dpc-1428 16 1 candidiasis candidiasis NOUN dpc-1428 16 2 , , PUNCT dpc-1428 16 3 psoriasis psoriasis NOUN dpc-1428 16 4 and and CCONJ dpc-1428 16 5 chronic chronic ADJ dpc-1428 16 6 lichen lichen NOUN dpc-1428 16 7 simplex simplex NOUN dpc-1428 16 8 should should AUX dpc-1428 16 9 be be AUX dpc-1428 16 10 considered consider VERB dpc-1428 16 11 in in ADP dpc-1428 16 12 the the DET dpc-1428 16 13 differential differential ADJ dpc-1428 16 14 diagnoses diagnosis NOUN dpc-1428 16 15 [ [ X dpc-1428 16 16 1 1 NUM dpc-1428 16 17 ] ] PUNCT dpc-1428 16 18 . . PUNCT dpc-1428 17 1 immunohistochemistry immunohistochemistry PROPN dpc-1428 17 2 studies study NOUN dpc-1428 17 3 became become VERB dpc-1428 17 4 the the DET dpc-1428 17 5 gold gold ADJ dpc-1428 17 6 standard standard NOUN dpc-1428 17 7 for for ADP dpc-1428 17 8 pathologic pathologic ADJ dpc-1428 17 9 prognosis prognosis NOUN dpc-1428 17 10 , , PUNCT dpc-1428 17 11 and and CCONJ dpc-1428 17 12 the the DET dpc-1428 17 13 data datum NOUN dpc-1428 17 14 for for ADP dpc-1428 17 15 empd empd NOUN dpc-1428 17 16 includes include VERB dpc-1428 17 17 cytokeratin cytokeratin NOUN dpc-1428 17 18 7 7 NUM dpc-1428 17 19 ( ( PUNCT dpc-1428 17 20 ck7 ck7 NOUN dpc-1428 17 21 ) ) PUNCT dpc-1428 17 22 that that PRON dpc-1428 17 23 appears appear VERB dpc-1428 17 24 to to PART dpc-1428 17 25 be be AUX dpc-1428 17 26 related relate VERB dpc-1428 17 27 to to PART dpc-1428 17 28 slow slow VERB dpc-1428 17 29 pathologic pathologic ADJ dpc-1428 17 30 progression progression NOUN dpc-1428 17 31 [ [ X dpc-1428 17 32 2 2 NUM dpc-1428 17 33 ] ] PUNCT dpc-1428 17 34 . . PUNCT dpc-1428 18 1 the the DET dpc-1428 18 2 histogenesis histogenesis NOUN dpc-1428 18 3 of of ADP dpc-1428 18 4 empd empd NOUN dpc-1428 18 5 is be AUX dpc-1428 18 6 complex complex ADJ dpc-1428 18 7 ; ; PUNCT dpc-1428 18 8 paget paget PROPN dpc-1428 18 9 cells cell NOUN dpc-1428 18 10 could could AUX dpc-1428 18 11 originate originate VERB dpc-1428 18 12 from from ADP dpc-1428 18 13 the the DET dpc-1428 18 14 underlying underlying ADJ dpc-1428 18 15 intraductal intraductal NOUN dpc-1428 18 16 cancer cancer NOUN dpc-1428 18 17 and and CCONJ dpc-1428 18 18 migrate migrate VERB dpc-1428 18 19 through through ADP dpc-1428 18 20 the the DET dpc-1428 18 21 basement basement NOUN dpc-1428 18 22 membrane membrane NOUN dpc-1428 18 23 to to ADP dpc-1428 18 24 the the DET dpc-1428 18 25 nipple nipple ADJ dpc-1428 18 26 or or CCONJ dpc-1428 18 27 genital genital ADJ dpc-1428 18 28 areas area NOUN dpc-1428 18 29 . . PUNCT dpc-1428 19 1 histopathology histopathology NOUN dpc-1428 19 2 represents represent VERB dpc-1428 19 3 the the DET dpc-1428 19 4 gold gold ADJ dpc-1428 19 5 standard standard NOUN dpc-1428 19 6 for for ADP dpc-1428 19 7 diagnosis diagnosis NOUN dpc-1428 19 8 of of ADP dpc-1428 19 9 empd empd NOUN dpc-1428 19 10 and and CCONJ dpc-1428 19 11 immunohistochemical immunohistochemical ADJ dpc-1428 19 12 staining staining ADJ dpc-1428 19 13 differentiates differentiate NOUN dpc-1428 19 14 between between ADP dpc-1428 19 15 this this DET dpc-1428 19 16 skin skin NOUN dpc-1428 19 17 disorder disorder NOUN dpc-1428 19 18 and and CCONJ dpc-1428 19 19 intraductal intraductal ADJ dpc-1428 19 20 cancer cancer NOUN dpc-1428 19 21 . . PUNCT dpc-1428 20 1 it it PRON dpc-1428 20 2 is be AUX dpc-1428 20 3 postulated postulate VERB dpc-1428 20 4 that that SCONJ dpc-1428 20 5 mammary mammary ADJ dpc-1428 20 6 paget paget NOUN dpc-1428 20 7 disease disease NOUN dpc-1428 20 8 as as ADP dpc-1428 20 9 an an DET dpc-1428 20 10 in in ADP dpc-1428 20 11 - - PUNCT dpc-1428 20 12 situ situ ADJ dpc-1428 20 13 carcinoma carcinoma NOUN dpc-1428 20 14 with with ADP dpc-1428 20 15 paget paget PROPN dpc-1428 20 16 cells cell NOUN dpc-1428 20 17 undergoing undergo VERB dpc-1428 20 18 malignant malignant ADJ dpc-1428 20 19 transformation transformation NOUN dpc-1428 20 20 . . PUNCT dpc-1428 21 1 surgical surgical ADJ dpc-1428 21 2 excision excision NOUN dpc-1428 21 3 and and CCONJ dpc-1428 21 4 micrographic micrographic ADJ dpc-1428 21 5 surgery surgery NOUN dpc-1428 21 6 are be AUX dpc-1428 21 7 generally generally ADV dpc-1428 21 8 the the DET dpc-1428 21 9 best good ADJ dpc-1428 21 10 treatment treatment NOUN dpc-1428 21 11 options option NOUN dpc-1428 21 12 , , PUNCT dpc-1428 21 13 although although SCONJ dpc-1428 21 14 recurrences recurrence NOUN dpc-1428 21 15 are be AUX dpc-1428 21 16 frequent frequent ADJ dpc-1428 21 17 because because SCONJ dpc-1428 21 18 it it PRON dpc-1428 21 19 is be AUX dpc-1428 21 20 difficult difficult ADJ dpc-1428 21 21 to to PART dpc-1428 21 22 obtain obtain VERB dpc-1428 21 23 optimal optimal ADJ dpc-1428 21 24 surgical surgical ADJ dpc-1428 21 25 margins margin NOUN dpc-1428 21 26 . . PUNCT dpc-1428 22 1 local local ADJ dpc-1428 22 2 recurrence recurrence NOUN dpc-1428 22 3 rates rate NOUN dpc-1428 22 4 after after ADP dpc-1428 22 5 surgery surgery NOUN dpc-1428 22 6 vary vary VERB dpc-1428 22 7 from from ADP dpc-1428 22 8 34 34 NUM dpc-1428 22 9 % % NOUN dpc-1428 22 10 to to ADP dpc-1428 22 11 56 56 NUM dpc-1428 22 12 % % NOUN dpc-1428 22 13 , , PUNCT dpc-1428 22 14 and and CCONJ dpc-1428 22 15 patients patient NOUN dpc-1428 22 16 often often ADV dpc-1428 22 17 experience experience VERB dpc-1428 22 18 a a DET dpc-1428 22 19 real real ADJ dpc-1428 22 20 “ " PUNCT dpc-1428 22 21 surgical surgical ADJ dpc-1428 22 22 calvary calvary NOUN dpc-1428 22 23 . . PUNCT dpc-1428 22 24 ” " PUNCT dpc-1428 23 1 in in ADP dpc-1428 23 2 cases case NOUN dpc-1428 23 3 of of ADP dpc-1428 23 4 very very ADV dpc-1428 23 5 extensive extensive ADJ dpc-1428 23 6 lesions lesion NOUN dpc-1428 23 7 or or CCONJ dpc-1428 23 8 difficult difficult ADJ dpc-1428 23 9 locations location NOUN dpc-1428 23 10 , , PUNCT dpc-1428 23 11 such such ADJ dpc-1428 23 12 as as ADP dpc-1428 23 13 the the DET dpc-1428 23 14 genital genital ADJ dpc-1428 23 15 localization localization NOUN dpc-1428 23 16 , , PUNCT dpc-1428 23 17 second second ADJ dpc-1428 23 18 - - PUNCT dpc-1428 23 19 line line NOUN dpc-1428 23 20 therapy therapy NOUN dpc-1428 23 21 such such ADJ dpc-1428 23 22 as as ADP dpc-1428 23 23 topical topical ADJ dpc-1428 23 24 therapy therapy NOUN dpc-1428 23 25 could could AUX dpc-1428 23 26 be be AUX dpc-1428 23 27 proposed propose VERB dpc-1428 23 28 . . PUNCT dpc-1428 24 1 case case NOUN dpc-1428 24 2 presentation presentation NOUN dpc-1428 24 3 we we PRON dpc-1428 24 4 performed perform VERB dpc-1428 24 5 2 2 NUM dpc-1428 24 6 surgeries surgery NOUN dpc-1428 24 7 on on ADP dpc-1428 24 8 a a DET dpc-1428 24 9 60 60 NUM dpc-1428 24 10 - - PUNCT dpc-1428 24 11 year year NOUN dpc-1428 24 12 - - PUNCT dpc-1428 24 13 old old ADJ dpc-1428 24 14 woman woman NOUN dpc-1428 24 15 to to PART dpc-1428 24 16 remove remove VERB dpc-1428 24 17 a a DET dpc-1428 24 18 lesion lesion NOUN dpc-1428 24 19 on on ADP dpc-1428 24 20 the the DET dpc-1428 24 21 left left ADJ dpc-1428 24 22 vulva vulva NOUN dpc-1428 24 23 . . PUNCT dpc-1428 25 1 a a DET dpc-1428 25 2 biopsy biopsy NOUN dpc-1428 25 3 was be AUX dpc-1428 25 4 performed perform VERB dpc-1428 25 5 and and CCONJ dpc-1428 25 6 was be AUX dpc-1428 25 7 in in ADP dpc-1428 25 8 line line NOUN dpc-1428 25 9 with with ADP dpc-1428 25 10 the the DET dpc-1428 25 11 clinical clinical ADJ dpc-1428 25 12 picture picture NOUN dpc-1428 25 13 ( ( PUNCT dpc-1428 25 14 figure figure NOUN dpc-1428 25 15 1 1 NUM dpc-1428 25 16 ) ) PUNCT dpc-1428 25 17 . . PUNCT dpc-1428 26 1 histopathological histopathological ADJ dpc-1428 26 2 letter letter NOUN dpc-1428 26 3 | | ADV dpc-1428 26 4 dermatol dermatol ADJ dpc-1428 26 5 pract pract NOUN dpc-1428 26 6 concept concept NOUN dpc-1428 26 7 2021;11(2):e2021011 2021;11(2):e2021011 NUM dpc-1428 26 8 figure figure NOUN dpc-1428 26 9 1 1 NUM dpc-1428 26 10 . . PUNCT dpc-1428 27 1 ( ( PUNCT dpc-1428 27 2 a a X dpc-1428 27 3 ) ) PUNCT dpc-1428 27 4 clinical clinical ADJ dpc-1428 27 5 image image NOUN dpc-1428 27 6 of of ADP dpc-1428 27 7 extramammary extramammary ADJ dpc-1428 27 8 paget paget NOUN dpc-1428 27 9 disease disease NOUN dpc-1428 27 10 before before ADP dpc-1428 27 11 treatment treatment NOUN dpc-1428 27 12 : : PUNCT dpc-1428 27 13 scaly scaly NOUN dpc-1428 27 14 lichenified lichenifie VERB dpc-1428 27 15 lesion lesion NOUN dpc-1428 27 16 on on ADP dpc-1428 27 17 the the DET dpc-1428 27 18 left left ADJ dpc-1428 27 19 vulva vulva NOUN dpc-1428 27 20 . . PUNCT dpc-1428 28 1 ( ( PUNCT dpc-1428 28 2 b b X dpc-1428 28 3 ) ) PUNCT dpc-1428 28 4 clinical clinical ADJ dpc-1428 28 5 image image NOUN dpc-1428 28 6 after after ADP dpc-1428 28 7 treatment treatment NOUN dpc-1428 28 8 with with ADP dpc-1428 28 9 3.75 3.75 NUM dpc-1428 28 10 % % NOUN dpc-1428 28 11 imiquimod imiquimod ADJ dpc-1428 28 12 : : PUNCT dpc-1428 28 13 clinical clinical ADJ dpc-1428 28 14 resolution resolution NOUN dpc-1428 28 15 with with ADP dpc-1428 28 16 slight slight ADJ dpc-1428 28 17 inflammation inflammation NOUN dpc-1428 28 18 due due ADP dpc-1428 28 19 to to ADP dpc-1428 28 20 the the DET dpc-1428 28 21 therapy therapy NOUN dpc-1428 28 22 . . PUNCT dpc-1428 29 1 ( ( PUNCT dpc-1428 29 2 c c X dpc-1428 29 3 ) ) PUNCT dpc-1428 29 4 dermoscopy dermoscopy NOUN dpc-1428 29 5 shows show VERB dpc-1428 29 6 the the DET dpc-1428 29 7 presence presence NOUN dpc-1428 29 8 of of ADP dpc-1428 29 9 structureless structureless ADJ dpc-1428 29 10 whitish whitish ADJ dpc-1428 29 11 areas area NOUN dpc-1428 29 12 . . PUNCT dpc-1428 30 1 ( ( PUNCT dpc-1428 30 2 d d X dpc-1428 30 3 ) ) PUNCT dpc-1428 30 4 dermoscopy dermoscopy NOUN dpc-1428 30 5 shows show VERB dpc-1428 30 6 conspicuous conspicuous ADJ dpc-1428 30 7 reduction reduction NOUN dpc-1428 30 8 in in ADP dpc-1428 30 9 whitish whitish ADJ dpc-1428 30 10 areas area NOUN dpc-1428 30 11 . . PUNCT dpc-1428 31 1 ( ( PUNCT dpc-1428 31 2 e e NOUN dpc-1428 31 3 ) ) PUNCT dpc-1428 31 4 histopathology histopathology NOUN dpc-1428 31 5 of of ADP dpc-1428 31 6 extramammary extramammary PROPN dpc-1428 31 7 paget paget PROPN dpc-1428 31 8 disease disease NOUN dpc-1428 31 9 ( ( PUNCT dpc-1428 31 10 h&e h&e PROPN dpc-1428 31 11 ) ) PUNCT dpc-1428 31 12 . . PUNCT dpc-1428 32 1 ( ( PUNCT dpc-1428 32 2 f f X dpc-1428 32 3 ) ) PUNCT dpc-1428 32 4     SPACE dpc-1428 32 5 cytokeratin cytokeratin NOUN dpc-1428 32 6 7 7 NUM dpc-1428 32 7 immunostaining immunostaining NOUN dpc-1428 32 8 shows show VERB dpc-1428 32 9 positivity positivity NOUN dpc-1428 32 10 at at ADP dpc-1428 32 11 the the DET dpc-1428 32 12 basalar basalar ADJ dpc-1428 32 13 level level NOUN dpc-1428 32 14 , , PUNCT dpc-1428 32 15 a a DET dpc-1428 32 16 positive positive ADJ dpc-1428 32 17 index index NOUN dpc-1428 32 18 of of ADP dpc-1428 32 19 paget paget PROPN dpc-1428 32 20 disease disease NOUN dpc-1428 32 21 . . PUNCT dpc-1428 33 1 ( ( PUNCT dpc-1428 33 2 g g NOUN dpc-1428 33 3 ) ) PUNCT dpc-1428 33 4 histopathology histopathology NOUN dpc-1428 33 5 after after SCONJ dpc-1428 33 6 treatment treatment NOUN dpc-1428 33 7 shows show VERB dpc-1428 33 8 a a DET dpc-1428 33 9 mild mild ADJ dpc-1428 33 10 perivascular perivascular ADJ dpc-1428 33 11 inflammatory inflammatory ADJ dpc-1428 33 12 infiltrate infiltrate NOUN dpc-1428 33 13 associated associate VERB dpc-1428 33 14 with with ADP dpc-1428 33 15 telangiectasias telangiectasia NOUN dpc-1428 33 16 in in ADP dpc-1428 33 17 the the DET dpc-1428 33 18 superficial superficial ADJ dpc-1428 33 19 chorion chorion NOUN dpc-1428 33 20 as as ADP dpc-1428 33 21 per per ADP dpc-1428 33 22 imiquimod imiquimod ADJ dpc-1428 33 23 response response NOUN dpc-1428 33 24 ( ( PUNCT dpc-1428 33 25 h&e h&e PROPN dpc-1428 33 26 ) ) PUNCT dpc-1428 33 27 . . PUNCT dpc-1428 34 1 letter letter NOUN dpc-1428 35 1 | | ADV dpc-1428 35 2 dermatol dermatol ADJ dpc-1428 35 3 pract pract NOUN dpc-1428 35 4 concept concept NOUN dpc-1428 35 5 2021;11(2):e2021011 2021;11(2):e2021011 NUM dpc-1428 35 6 3 3 NUM dpc-1428 35 7 examination examination NOUN dpc-1428 35 8 and and CCONJ dpc-1428 35 9 immunohistochemical immunohistochemical ADJ dpc-1428 35 10 profile profile NOUN dpc-1428 35 11 corroborated corroborate VERB dpc-1428 35 12 a a DET dpc-1428 35 13 diagnosis diagnosis NOUN dpc-1428 35 14 of of ADP dpc-1428 35 15 empd empd NOUN dpc-1428 35 16 ( ( PUNCT dpc-1428 35 17 figure figure NOUN dpc-1428 35 18 1 1 NUM dpc-1428 35 19 , , PUNCT dpc-1428 35 20 e e NOUN dpc-1428 35 21 and and CCONJ dpc-1428 35 22 f f X dpc-1428 35 23 ) ) PUNCT dpc-1428 35 24 . . PUNCT dpc-1428 36 1 we we PRON dpc-1428 36 2 prescribed prescribe VERB dpc-1428 36 3 imiquimod imiquimod ADJ dpc-1428 36 4 3.75 3.75 NUM dpc-1428 36 5 % % NOUN dpc-1428 36 6 following follow VERB dpc-1428 36 7 the the DET dpc-1428 36 8 dosage dosage NOUN dpc-1428 36 9 guidelines guideline NOUN dpc-1428 36 10 : : PUNCT dpc-1428 36 11 once once ADV dpc-1428 36 12 daily daily ADV dpc-1428 36 13 for for ADP dpc-1428 36 14 15 15 NUM dpc-1428 36 15 days day NOUN dpc-1428 36 16 , , PUNCT dpc-1428 36 17 subsequently subsequently ADV dpc-1428 36 18 interrupting interrupt VERB dpc-1428 36 19 therapy therapy NOUN dpc-1428 36 20 for for ADP dpc-1428 36 21 15 15 NUM dpc-1428 36 22 days day NOUN dpc-1428 36 23 , , PUNCT dpc-1428 36 24 and and CCONJ dpc-1428 36 25 again again ADV dpc-1428 36 26 once once ADV dpc-1428 36 27 a a DET dpc-1428 36 28 day day NOUN dpc-1428 36 29 for for ADP dpc-1428 36 30 other other ADJ dpc-1428 36 31 15 15 NUM dpc-1428 36 32 days day NOUN dpc-1428 36 33 . . PUNCT dpc-1428 37 1 after after ADP dpc-1428 37 2 about about ADV dpc-1428 37 3 5 5 NUM dpc-1428 37 4 months month NOUN dpc-1428 37 5 she she PRON dpc-1428 37 6 repeated repeat VERB dpc-1428 37 7 another another DET dpc-1428 37 8 therapy therapy NOUN dpc-1428 37 9 session session NOUN dpc-1428 37 10 and and CCONJ dpc-1428 37 11 achieved achieve VERB dpc-1428 37 12 good good ADJ dpc-1428 37 13 clearance clearance NOUN dpc-1428 37 14 of of ADP dpc-1428 37 15 the the DET dpc-1428 37 16 lesions lesion NOUN dpc-1428 37 17 without without ADP dpc-1428 37 18 obvious obvious ADJ dpc-1428 37 19 side side NOUN dpc-1428 37 20 effects effect NOUN dpc-1428 37 21 or or CCONJ dpc-1428 37 22 post post ADJ dpc-1428 37 23 - - ADJ dpc-1428 37 24 surgical surgical ADJ dpc-1428 37 25 sequelae sequelae NOUN dpc-1428 37 26 . . PUNCT dpc-1428 38 1 there there PRON dpc-1428 38 2 was be VERB dpc-1428 38 3 clinical clinical ADJ dpc-1428 38 4 and and CCONJ dpc-1428 38 5 dermoscopic dermoscopic ADJ dpc-1428 38 6 improvement improvement NOUN dpc-1428 38 7 of of ADP dpc-1428 38 8 the the DET dpc-1428 38 9 lesion lesion NOUN dpc-1428 38 10 after after ADP dpc-1428 38 11 treatment treatment NOUN dpc-1428 38 12 ( ( PUNCT dpc-1428 38 13 figure figure NOUN dpc-1428 38 14 1d 1d NUM dpc-1428 38 15 ) ) PUNCT dpc-1428 38 16 . . PUNCT dpc-1428 39 1 after after ADP dpc-1428 39 2 treatment treatment NOUN dpc-1428 39 3 , , PUNCT dpc-1428 39 4 a a DET dpc-1428 39 5 biopsy biopsy NOUN dpc-1428 39 6 was be AUX dpc-1428 39 7 performed perform VERB dpc-1428 39 8 to to PART dpc-1428 39 9 confirm confirm VERB dpc-1428 39 10 empd empd NOUN dpc-1428 39 11 absence absence NOUN dpc-1428 39 12 ( ( PUNCT dpc-1428 39 13 figure figure NOUN dpc-1428 39 14 1 1 NUM dpc-1428 39 15 g g NOUN dpc-1428 39 16 ) ) PUNCT dpc-1428 39 17 . . PUNCT dpc-1428 40 1 we we PRON dpc-1428 40 2 used use VERB dpc-1428 40 3 the the DET dpc-1428 40 4 topical topical ADJ dpc-1428 40 5 disease disease NOUN dpc-1428 40 6 approach approach NOUN dpc-1428 40 7 for for ADP dpc-1428 40 8 this this DET dpc-1428 40 9 case case NOUN dpc-1428 40 10 of of ADP dpc-1428 40 11 ck7 ck7 NOUN dpc-1428 40 12 + + CCONJ dpc-1428 40 13 low low ADJ dpc-1428 40 14 progression progression NOUN dpc-1428 40 15 empd empd NOUN dpc-1428 40 16 to to PART dpc-1428 40 17 avoid avoid VERB dpc-1428 40 18 another another DET dpc-1428 40 19 surgery surgery NOUN dpc-1428 40 20 and and CCONJ dpc-1428 40 21 the the DET dpc-1428 40 22 high high ADJ dpc-1428 40 23 psychological psychological ADJ dpc-1428 40 24 and and CCONJ dpc-1428 40 25 physical physical ADJ dpc-1428 40 26 impact impact NOUN dpc-1428 40 27 it it PRON dpc-1428 40 28 might might AUX dpc-1428 40 29 have have VERB dpc-1428 40 30 , , PUNCT dpc-1428 40 31 reclaim reclaim VERB dpc-1428 40 32 the the DET dpc-1428 40 33 previously previously ADV dpc-1428 40 34 excised excise VERB dpc-1428 40 35 region region NOUN dpc-1428 40 36 , , PUNCT dpc-1428 40 37 and and CCONJ dpc-1428 40 38 minimize minimize VERB dpc-1428 40 39 the the DET dpc-1428 40 40 use use NOUN dpc-1428 40 41 of of ADP dpc-1428 40 42 drugs drug NOUN dpc-1428 40 43 in in ADP dpc-1428 40 44 order order NOUN dpc-1428 40 45 to to PART dpc-1428 40 46 reduce reduce VERB dpc-1428 40 47 local local ADJ dpc-1428 40 48 adverse adverse ADJ dpc-1428 40 49 events event NOUN dpc-1428 40 50 . . PUNCT dpc-1428 41 1 conclusions conclusion NOUN dpc-1428 41 2 topical topical ADJ dpc-1428 41 3 imiquimod imiquimod ADJ dpc-1428 41 4 3.75 3.75 NUM dpc-1428 41 5 % % NOUN dpc-1428 41 6 is be AUX dpc-1428 41 7 an an DET dpc-1428 41 8 excellent excellent ADJ dpc-1428 41 9 therapeutic therapeutic ADJ dpc-1428 41 10 tool tool NOUN dpc-1428 41 11 for for ADP dpc-1428 41 12 ck7 ck7 PROPN dpc-1428 41 13 + + PROPN dpc-1428 41 14 empd empd NOUN dpc-1428 41 15 in in ADP dpc-1428 41 16 cases case NOUN dpc-1428 41 17 when when SCONJ dpc-1428 41 18 surgery surgery NOUN dpc-1428 41 19 is be AUX dpc-1428 41 20 not not PART dpc-1428 41 21 recommended recommend VERB dpc-1428 41 22 . . PUNCT dpc-1428 42 1 imiquimod imiquimod PROPN dpc-1428 42 2 could could AUX dpc-1428 42 3 also also ADV dpc-1428 42 4 be be AUX dpc-1428 42 5 used use VERB dpc-1428 42 6 in in ADP dpc-1428 42 7 cases case NOUN dpc-1428 42 8 of of ADP dpc-1428 42 9 recurrence recurrence NOUN dpc-1428 42 10 or or CCONJ dpc-1428 42 11 in in ADP dpc-1428 42 12 a a DET dpc-1428 42 13 post post ADJ dpc-1428 42 14 - - ADJ dpc-1428 42 15 adjuvant adjuvant ADJ dpc-1428 42 16 therapy therapy NOUN dpc-1428 42 17 regime regime NOUN dpc-1428 42 18 to to PART dpc-1428 42 19 avoid avoid VERB dpc-1428 42 20 the the DET dpc-1428 42 21 risk risk NOUN dpc-1428 42 22 of of ADP dpc-1428 42 23 disease disease NOUN dpc-1428 42 24 relapse relapse NOUN dpc-1428 42 25 , , PUNCT dpc-1428 42 26 or or CCONJ dpc-1428 42 27 to to PART dpc-1428 42 28 avoid avoid VERB dpc-1428 42 29 permanent permanent ADJ dpc-1428 42 30 anogenital anogenital ADJ dpc-1428 42 31 mutilation mutilation NOUN dpc-1428 42 32 and and CCONJ dpc-1428 42 33 functional functional ADJ dpc-1428 42 34 impairment impairment NOUN dpc-1428 42 35 after after ADP dpc-1428 42 36 surgery surgery NOUN dpc-1428 42 37 . . PUNCT dpc-1428 43 1 more more ADJ dpc-1428 43 2 studies study NOUN dpc-1428 43 3 are be AUX dpc-1428 43 4 required require VERB dpc-1428 43 5 to to PART dpc-1428 43 6 evaluate evaluate VERB dpc-1428 43 7 tailor tailor NOUN dpc-1428 43 8 - - PUNCT dpc-1428 43 9 made make VERB dpc-1428 43 10 therapies therapy NOUN dpc-1428 43 11 based base VERB dpc-1428 43 12 on on ADP dpc-1428 43 13 the the DET dpc-1428 43 14 empd empd NOUN dpc-1428 43 15 histopathological histopathological ADJ dpc-1428 43 16 phenotype phenotype NOUN dpc-1428 43 17 , , PUNCT dpc-1428 43 18 stains stain NOUN dpc-1428 43 19 and and CCONJ dpc-1428 43 20 molecular molecular ADJ dpc-1428 43 21 markers marker NOUN dpc-1428 43 22 . . PUNCT dpc-1428 43 23     SPACE dpc-1428 44 1 references reference NOUN dpc-1428 44 2 1 1 NUM dpc-1428 44 3 . . PUNCT dpc-1428 44 4 st st PROPN dpc-1428 44 5 claire claire PROPN dpc-1428 44 6 k k PROPN dpc-1428 44 7 , , PUNCT dpc-1428 44 8 hoover hoover NOUN dpc-1428 44 9 a a NOUN dpc-1428 44 10 , , PUNCT dpc-1428 44 11 ashack ashack NOUN dpc-1428 44 12 k k NOUN dpc-1428 44 13 , , PUNCT dpc-1428 44 14 khachemoune khachemoune PROPN dpc-1428 44 15 a. a. PROPN dpc-1428 44 16 extramammary extramammary PROPN dpc-1428 44 17 paget paget PROPN dpc-1428 44 18 disease disease PROPN dpc-1428 44 19 . . PUNCT dpc-1428 45 1 dermatol dermatol NOUN dpc-1428 45 2 online online PROPN dpc-1428 45 3 j. j. PROPN dpc-1428 45 4 2019;25(4):13030 2019;25(4):13030 PROPN dpc-1428 45 5 / / SYM dpc-1428 45 6 qt7qg8g292 qt7qg8g292 PROPN dpc-1428 45 7 . . PUNCT dpc-1428 46 1 pmid pmid NOUN dpc-1428 46 2 : : PUNCT dpc-1428 46 3 31046904 31046904 NUM dpc-1428 46 4 . . PUNCT dpc-1428 47 1 2 2 X dpc-1428 47 2 . . X dpc-1428 47 3 damavandy damavandy PROPN dpc-1428 47 4 aa aa PROPN dpc-1428 47 5 , , PUNCT dpc-1428 47 6 terushkin terushkin PROPN dpc-1428 47 7 v v PROPN dpc-1428 47 8 , , PUNCT dpc-1428 47 9 zitelli zitelli PROPN dpc-1428 47 10 ja ja PROPN dpc-1428 47 11 , , PUNCT dpc-1428 47 12 et et PROPN dpc-1428 47 13 al al PROPN dpc-1428 47 14 . . PROPN dpc-1428 47 15 intraoperative intraoperative PROPN dpc-1428 47 16 immunostaining immunostaine VERB dpc-1428 47 17 for for ADP dpc-1428 47 18 cytokeratin-7 cytokeratin-7 NUM dpc-1428 47 19 during during ADP dpc-1428 47 20 mohs mohs NOUN dpc-1428 47 21 micrographic micrographic ADJ dpc-1428 47 22 surgery surgery NOUN dpc-1428 47 23 demonstrates demonstrate VERB dpc-1428 47 24 low low ADJ dpc-1428 47 25 local local ADJ dpc-1428 47 26 recurrence recurrence NOUN dpc-1428 47 27 rates rate NOUN dpc-1428 47 28 in in ADP dpc-1428 47 29 extramammary extramammary PROPN dpc-1428 47 30 paget paget PROPN dpc-1428 47 31 ’s ’s PART dpc-1428 47 32 disease disease NOUN dpc-1428 47 33 . . PUNCT dpc-1428 48 1 dermatol dermatol NOUN dpc-1428 48 2 surg surg NOUN dpc-1428 48 3 . . PUNCT dpc-1428 49 1 2018;44(3):354 2018;44(3):354 NUM dpc-1428 49 2 - - SYM dpc-1428 49 3 364 364 NUM dpc-1428 49 4 . . PUNCT dpc-1428 50 1 doi doi NOUN dpc-1428 50 2 : : PUNCT dpc-1428 50 3 10.1097/ 10.1097/ NUM dpc-1428 50 4 dss.0000000000001355 dss.0000000000001355 NUM dpc-1428 50 5 . . PUNCT dpc-1428 51 1 pmid pmid NOUN dpc-1428 51 2 : : PUNCT dpc-1428 51 3 29517496 29517496 NUM dpc-1428 51 4 . . PUNCT dpc-1428 51 5     SPACE