id sid tid token lemma pos dpc-1840 1 1 dermatology dermatology NOUN dpc-1840 1 2 : : PUNCT dpc-1840 1 3 practical practical ADJ dpc-1840 1 4 and and CCONJ dpc-1840 1 5 conceptual conceptual ADJ dpc-1840 1 6 research research NOUN dpc-1840 1 7 letter letter NOUN dpc-1840 2 1 | | ADV dpc-1840 2 2 dermatol dermatol ADJ dpc-1840 2 3 pract pract NOUN dpc-1840 2 4 concept concept NOUN dpc-1840 2 5 . . PUNCT dpc-1840 3 1 2022;12(2):e2022058 2022;12(2):e2022058 NUM dpc-1840 3 2 1 1 NUM dpc-1840 3 3 recurrent recurrent ADJ dpc-1840 3 4 acute acute NOUN dpc-1840 3 5 generalized generalize VERB dpc-1840 3 6 exanthematous exanthematous ADJ dpc-1840 3 7 pustulosis pustulosis NOUN dpc-1840 3 8 to to ADP dpc-1840 3 9 two two NUM dpc-1840 3 10 different different ADJ dpc-1840 3 11 drugs drug NOUN dpc-1840 3 12 : : PUNCT dpc-1840 3 13 oxacillin oxacillin NOUN dpc-1840 3 14 and and CCONJ dpc-1840 3 15 dextromethorphan dextromethorphan PROPN dpc-1840 3 16 confirmed confirm VERB dpc-1840 3 17 by by ADP dpc-1840 3 18 patch patch PROPN dpc-1840 3 19 test test NOUN dpc-1840 3 20 zied zied PROPN dpc-1840 3 21 kenani1 kenani1 PROPN dpc-1840 3 22 , , PUNCT dpc-1840 3 23 rima rima PROPN dpc-1840 3 24 gammoudi1 gammoudi1 PROPN dpc-1840 3 25 , , PUNCT dpc-1840 3 26 neila neila PROPN dpc-1840 3 27 fathallah2 fathallah2 PROPN dpc-1840 3 28 , , PUNCT dpc-1840 3 29 amina amina PROPN dpc-1840 3 30 aounallah1 aounallah1 PROPN dpc-1840 3 31 , , PUNCT dpc-1840 3 32 sana sana PROPN dpc-1840 3 33 mokni1 mokni1 PROPN dpc-1840 3 34 , , PUNCT dpc-1840 3 35 lobna lobna PROPN dpc-1840 3 36 boussofara1 boussofara1 PROPN dpc-1840 3 37 , , PUNCT dpc-1840 3 38 nejet nejet NOUN dpc-1840 3 39 ghariani1 ghariani1 PROPN dpc-1840 3 40 , , PUNCT dpc-1840 3 41 colandane colandane NOUN dpc-1840 3 42 belajouza1 belajouza1 PROPN dpc-1840 3 43 , , PUNCT dpc-1840 3 44 chaker chaker PROPN dpc-1840 3 45 ben ben PROPN dpc-1840 3 46 salem2 salem2 PROPN dpc-1840 3 47 , , PUNCT dpc-1840 3 48 mohamed mohamed PROPN dpc-1840 3 49 denguezli1 denguezli1 PROPN dpc-1840 3 50 1 1 NUM dpc-1840 3 51 department department NOUN dpc-1840 3 52 of of ADP dpc-1840 3 53 dermatology dermatology NOUN dpc-1840 3 54 , , PUNCT dpc-1840 3 55 farhat farhat PROPN dpc-1840 3 56 hached hache VERB dpc-1840 3 57 hospital hospital NOUN dpc-1840 3 58 , , PUNCT dpc-1840 3 59 sousse sousse PROPN dpc-1840 3 60 , , PUNCT dpc-1840 3 61 tunisia tunisia PROPN dpc-1840 3 62 2 2 NUM dpc-1840 3 63 department department NOUN dpc-1840 3 64 of of ADP dpc-1840 3 65 pharmacovigilance pharmacovigilance NOUN dpc-1840 3 66 , , PUNCT dpc-1840 3 67 reference reference NOUN dpc-1840 3 68 center center NOUN dpc-1840 3 69 for for ADP dpc-1840 3 70 cutaneous cutaneous ADJ dpc-1840 3 71 adverse adverse ADJ dpc-1840 3 72 reactions reaction NOUN dpc-1840 3 73 , , PUNCT dpc-1840 3 74 faculty faculty NOUN dpc-1840 3 75 of of ADP dpc-1840 3 76 medicine medicine NOUN dpc-1840 3 77 , , PUNCT dpc-1840 3 78 university university NOUN dpc-1840 3 79 of of ADP dpc-1840 3 80 sousse sousse PROPN dpc-1840 3 81 , , PUNCT dpc-1840 3 82 sousse sousse PROPN dpc-1840 3 83 , , PUNCT dpc-1840 3 84 tunisia tunisia PROPN dpc-1840 3 85 . . PUNCT dpc-1840 4 1 key key ADJ dpc-1840 4 2 words word NOUN dpc-1840 4 3 : : PUNCT dpc-1840 4 4 acute acute NOUN dpc-1840 4 5 generalized generalize VERB dpc-1840 4 6 exanthematous exanthematous ADJ dpc-1840 4 7 pustulosis pustulosis NOUN dpc-1840 4 8 , , PUNCT dpc-1840 4 9 oxacillin oxacillin NOUN dpc-1840 4 10 , , PUNCT dpc-1840 4 11 dextromethorphan dextromethorphan PROPN dpc-1840 4 12 , , PUNCT dpc-1840 4 13 recurrence recurrence NOUN dpc-1840 4 14 , , PUNCT dpc-1840 4 15 patch patch ADJ dpc-1840 4 16 test test NOUN dpc-1840 4 17 citation citation NOUN dpc-1840 4 18 : : PUNCT dpc-1840 4 19 kenani kenani PROPN dpc-1840 4 20 z z PROPN dpc-1840 4 21 , , PUNCT dpc-1840 4 22 gammoudi gammoudi PROPN dpc-1840 4 23 r r NOUN dpc-1840 4 24 , , PUNCT dpc-1840 4 25 fathallah fathallah PROPN dpc-1840 4 26 n n INTJ dpc-1840 4 27 et et PROPN dpc-1840 4 28 al al PROPN dpc-1840 4 29 . . PROPN dpc-1840 4 30 recurrent recurrent PROPN dpc-1840 4 31 acute acute PROPN dpc-1840 4 32 generalized generalize VERB dpc-1840 4 33 exanthematous exanthematous ADJ dpc-1840 4 34 pustulosis pustulosis NOUN dpc-1840 4 35 to to ADP dpc-1840 4 36 two two NUM dpc-1840 4 37 different different ADJ dpc-1840 4 38 drugs drug NOUN dpc-1840 4 39 : : PUNCT dpc-1840 4 40 oxacillin oxacillin NOUN dpc-1840 4 41 and and CCONJ dpc-1840 4 42 dextromethorphan dextromethorphan PROPN dpc-1840 4 43 confirmed confirm VERB dpc-1840 4 44 by by ADP dpc-1840 4 45 patch patch ADJ dpc-1840 4 46 test test NOUN dpc-1840 4 47 . . PUNCT dpc-1840 5 1 dermatol dermatol NOUN dpc-1840 5 2 pract pract PROPN dpc-1840 5 3 concept concept NOUN dpc-1840 5 4 . . PUNCT dpc-1840 6 1 2022;12(2):e2022058 2022;12(2):e2022058 NUM dpc-1840 6 2 . . X dpc-1840 6 3 doi doi NOUN dpc-1840 6 4 : : PUNCT dpc-1840 6 5 https://doi.org/10.5826/dpc.1202a58 https://doi.org/10.5826/dpc.1202a58 NOUN dpc-1840 6 6 accepted accept VERB dpc-1840 6 7 : : PUNCT dpc-1840 6 8 august august PROPN dpc-1840 6 9 24 24 NUM dpc-1840 6 10 , , PUNCT dpc-1840 6 11 2021 2021 NUM dpc-1840 6 12 ; ; PUNCT dpc-1840 6 13 published publish VERB dpc-1840 6 14 : : PUNCT dpc-1840 6 15 april april PROPN dpc-1840 6 16 2022 2022 NUM dpc-1840 7 1 copyright copyright NOUN dpc-1840 7 2 : : PUNCT dpc-1840 7 3 © © PROPN dpc-1840 7 4 2022 2022 NUM dpc-1840 7 5 kenani kenani NOUN dpc-1840 7 6 et et PROPN dpc-1840 7 7 al al PROPN dpc-1840 7 8 . . PUNCT dpc-1840 8 1 this this PRON dpc-1840 8 2 is be AUX dpc-1840 8 3 an an DET dpc-1840 8 4 open open ADJ dpc-1840 8 5 - - PUNCT dpc-1840 8 6 access access NOUN dpc-1840 8 7 article article NOUN dpc-1840 8 8 distributed distribute VERB dpc-1840 8 9 under under ADP dpc-1840 8 10 the the DET dpc-1840 8 11 terms term NOUN dpc-1840 8 12 of of ADP dpc-1840 8 13 the the DET dpc-1840 8 14 creative creative ADJ dpc-1840 8 15 commons common NOUN dpc-1840 8 16 attributionnoncommercial attributionnoncommercial ADJ dpc-1840 8 17 license license NOUN dpc-1840 8 18 ( ( PUNCT dpc-1840 8 19 by by ADP dpc-1840 8 20 - - PUNCT dpc-1840 8 21 nc-4.0 nc-4.0 NOUN dpc-1840 8 22 ) ) PUNCT dpc-1840 8 23 , , PUNCT dpc-1840 8 24 https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ PROPN dpc-1840 8 25 , , PUNCT dpc-1840 8 26 which which PRON dpc-1840 8 27 permits permit VERB dpc-1840 8 28 unrestricted unrestricted ADJ dpc-1840 8 29 noncommercial noncommercial ADJ dpc-1840 8 30 use use NOUN dpc-1840 8 31 , , PUNCT dpc-1840 8 32 distribution distribution NOUN dpc-1840 8 33 , , PUNCT dpc-1840 8 34 and and CCONJ dpc-1840 8 35 reproduction reproduction NOUN dpc-1840 8 36 in in ADP dpc-1840 8 37 any any DET dpc-1840 8 38 medium medium NOUN dpc-1840 8 39 , , PUNCT dpc-1840 8 40 provided provide VERB dpc-1840 8 41 the the DET dpc-1840 8 42 original original ADJ dpc-1840 8 43 authors author NOUN dpc-1840 8 44 and and CCONJ dpc-1840 8 45 source source NOUN dpc-1840 8 46 are be AUX dpc-1840 8 47 credited credit VERB dpc-1840 8 48 . . PUNCT dpc-1840 9 1 funding funding NOUN dpc-1840 9 2 : : PUNCT dpc-1840 9 3 none none NOUN dpc-1840 9 4 . . PUNCT dpc-1840 10 1 competing compete VERB dpc-1840 10 2 interests interest NOUN dpc-1840 10 3 : : PUNCT dpc-1840 10 4 none none NOUN dpc-1840 10 5 . . PUNCT dpc-1840 11 1 authorship authorship NOUN dpc-1840 11 2 : : PUNCT dpc-1840 11 3 all all DET dpc-1840 11 4 authors author NOUN dpc-1840 11 5 have have AUX dpc-1840 11 6 contributed contribute VERB dpc-1840 11 7 significantly significantly ADV dpc-1840 11 8 to to ADP dpc-1840 11 9 this this DET dpc-1840 11 10 publication publication NOUN dpc-1840 11 11 corresponding correspond VERB dpc-1840 11 12 author author NOUN dpc-1840 11 13 : : PUNCT dpc-1840 11 14 zied zie VERB dpc-1840 11 15 kenani kenani PROPN dpc-1840 11 16 , , PUNCT dpc-1840 11 17 md md PROPN dpc-1840 11 18 , , PUNCT dpc-1840 11 19 department department PROPN dpc-1840 11 20 of of ADP dpc-1840 11 21 dermatology dermatology NOUN dpc-1840 11 22 , , PUNCT dpc-1840 11 23 farhat farhat PROPN dpc-1840 11 24 hached hache VERB dpc-1840 11 25 hospital hospital NOUN dpc-1840 11 26 , , PUNCT dpc-1840 11 27 avenue avenue PROPN dpc-1840 11 28 ibn ibn PROPN dpc-1840 11 29 jazzar jazzar PROPN dpc-1840 11 30 , , PUNCT dpc-1840 11 31 4002 4002 NUM dpc-1840 11 32 , , PUNCT dpc-1840 11 33 sousse sousse PROPN dpc-1840 11 34 , , PUNCT dpc-1840 11 35 tunisia tunisia PROPN dpc-1840 11 36 . . PUNCT dpc-1840 12 1 e e X dpc-1840 12 2 - - NOUN dpc-1840 12 3 mail mail NOUN dpc-1840 12 4 : : PUNCT dpc-1840 13 1 zieedken@gmail.com zieedken@gmail.com X dpc-1840 13 2 introduction introduction NOUN dpc-1840 13 3 acute acute NOUN dpc-1840 13 4 generalized generalize VERB dpc-1840 13 5 exanthematous exanthematous ADJ dpc-1840 13 6 pustulosis pustulosis NOUN dpc-1840 13 7 ( ( PUNCT dpc-1840 13 8 agep agep NOUN dpc-1840 13 9 ) ) PUNCT dpc-1840 13 10 is be AUX dpc-1840 13 11 a a DET dpc-1840 13 12 potentially potentially ADV dpc-1840 13 13 severe severe ADJ dpc-1840 13 14 skin skin NOUN dpc-1840 13 15 condition condition NOUN dpc-1840 13 16 , , PUNCT dpc-1840 13 17 mainly mainly ADV dpc-1840 13 18 drug drug NOUN dpc-1840 13 19 induced induce VERB dpc-1840 13 20 [ [ PUNCT dpc-1840 13 21 1 1 NUM dpc-1840 13 22 ] ] PUNCT dpc-1840 13 23 . . PUNCT dpc-1840 14 1 recurrences recurrence NOUN dpc-1840 14 2 are be AUX dpc-1840 14 3 rare rare ADJ dpc-1840 14 4 and and CCONJ dpc-1840 14 5 generally generally ADV dpc-1840 14 6 induced induce VERB dpc-1840 14 7 by by ADP dpc-1840 14 8 related related ADJ dpc-1840 14 9 drugs drug NOUN dpc-1840 14 10 . . PUNCT dpc-1840 15 1 dextromethorphan dextromethorphan PROPN dpc-1840 15 2 is be AUX dpc-1840 15 3 an an DET dpc-1840 15 4 antitussive antitussive NOUN dpc-1840 15 5 agent agent NOUN dpc-1840 15 6 which which PRON dpc-1840 15 7 is be AUX dpc-1840 15 8 unusually unusually ADV dpc-1840 15 9 reported report VERB dpc-1840 15 10 as as ADP dpc-1840 15 11 culprit culprit NOUN dpc-1840 15 12 in in ADP dpc-1840 15 13 agep agep NOUN dpc-1840 15 14 . . PUNCT dpc-1840 16 1 herein herein NOUN dpc-1840 16 2 we we PRON dpc-1840 16 3 report report VERB dpc-1840 16 4 a a DET dpc-1840 16 5 rare rare ADJ dpc-1840 16 6 case case NOUN dpc-1840 16 7 of of ADP dpc-1840 16 8 relapsing relapse VERB dpc-1840 16 9 agep agep NOUN dpc-1840 16 10 to to ADP dpc-1840 16 11 dextromethorphan dextromethorphan PROPN dpc-1840 16 12 and and CCONJ dpc-1840 16 13 oxacillin oxacillin PROPN dpc-1840 16 14 . . PUNCT dpc-1840 17 1 case case NOUN dpc-1840 17 2 presentation presentation NOUN dpc-1840 17 3 a a DET dpc-1840 17 4 32 32 NUM dpc-1840 17 5 - - PUNCT dpc-1840 17 6 year year NOUN dpc-1840 17 7 - - PUNCT dpc-1840 17 8 old old ADJ dpc-1840 17 9 woman woman NOUN dpc-1840 17 10 , , PUNCT dpc-1840 17 11 with with ADP dpc-1840 17 12 a a DET dpc-1840 17 13 history history NOUN dpc-1840 17 14 of of ADP dpc-1840 17 15 a a DET dpc-1840 17 16 controlled control VERB dpc-1840 17 17 generalized generalized ADJ dpc-1840 17 18 pustular pustular ADJ dpc-1840 17 19 psoriasis psoriasis NOUN dpc-1840 17 20 , , PUNCT dpc-1840 17 21 presented present VERB dpc-1840 17 22 to to ADP dpc-1840 17 23 our our PRON dpc-1840 17 24 department department NOUN dpc-1840 17 25 with with ADP dpc-1840 17 26 a a DET dpc-1840 17 27 4 4 NUM dpc-1840 17 28 day day NOUN dpc-1840 17 29 history history NOUN dpc-1840 17 30 of of ADP dpc-1840 17 31 fever fever NOUN dpc-1840 17 32 with with ADP dpc-1840 17 33 predominately predominately ADV dpc-1840 17 34 flexural flexural ADJ dpc-1840 17 35 eruption eruption NOUN dpc-1840 17 36 of of ADP dpc-1840 17 37 non non ADJ dpc-1840 17 38 - - ADJ dpc-1840 17 39 follicular follicular ADJ dpc-1840 17 40 pustules pustule NOUN dpc-1840 17 41 on on ADP dpc-1840 17 42 a a DET dpc-1840 17 43 erythematous erythematous ADJ dpc-1840 17 44 background background NOUN dpc-1840 17 45 , , PUNCT dpc-1840 17 46 which which PRON dpc-1840 17 47 had have AUX dpc-1840 17 48 started start VERB dpc-1840 17 49 2 2 NUM dpc-1840 17 50 days day NOUN dpc-1840 17 51 after after ADP dpc-1840 17 52 the the DET dpc-1840 17 53 intake intake NOUN dpc-1840 17 54 of of ADP dpc-1840 17 55 oxacillin oxacillin NOUN dpc-1840 17 56 and and CCONJ dpc-1840 17 57 tiaprofenic tiaprofenic ADJ dpc-1840 17 58 acid acid NOUN dpc-1840 17 59 . . PUNCT dpc-1840 18 1 investigations investigation NOUN dpc-1840 18 2 found find VERB dpc-1840 18 3 an an DET dpc-1840 18 4 elevated elevated ADJ dpc-1840 18 5 absolute absolute ADJ dpc-1840 18 6 neutrophil neutrophil ADJ dpc-1840 18 7 count count NOUN dpc-1840 18 8 and and CCONJ dpc-1840 18 9 skin skin NOUN dpc-1840 18 10 biopsy biopsy NOUN dpc-1840 18 11 demonstrated demonstrate VERB dpc-1840 18 12 histologic histologic NOUN dpc-1840 18 13 features feature NOUN dpc-1840 18 14 consistent consistent ADJ dpc-1840 18 15 with with ADP dpc-1840 18 16 agep agep NOUN dpc-1840 18 17 . . PUNCT dpc-1840 19 1 skin skin NOUN dpc-1840 19 2 lesions lesion NOUN dpc-1840 19 3 totally totally ADV dpc-1840 19 4 resolved resolve VERB dpc-1840 19 5 within within ADP dpc-1840 19 6 10 10 NUM dpc-1840 19 7 days day NOUN dpc-1840 19 8 after after ADP dpc-1840 19 9 oxacillin oxacillin ADJ dpc-1840 19 10 discontinuation discontinuation NOUN dpc-1840 19 11 . . PUNCT dpc-1840 20 1 a a DET dpc-1840 20 2 patch patch ADJ dpc-1840 20 3 test test NOUN dpc-1840 20 4 with with ADP dpc-1840 20 5 oxacillin oxacillin NOUN dpc-1840 20 6 and and CCONJ dpc-1840 20 7 tiaprofenic tiaprofenic ADJ dpc-1840 20 8 acid acid NOUN dpc-1840 20 9 ( ( PUNCT dpc-1840 20 10 the the DET dpc-1840 20 11 commercialized commercialize VERB dpc-1840 20 12 form form NOUN dpc-1840 20 13 used use VERB dpc-1840 20 14 by by ADP dpc-1840 20 15 the the DET dpc-1840 20 16 patient patient NOUN dpc-1840 20 17 diluted dilute VERB dpc-1840 20 18 to to ADP dpc-1840 20 19 30 30 NUM dpc-1840 20 20 % % NOUN dpc-1840 20 21 pet pet NOUN dpc-1840 20 22 . . PUNCT dpc-1840 20 23 ) ) PUNCT dpc-1840 20 24 was be AUX dpc-1840 20 25 performed perform VERB dpc-1840 20 26 and and CCONJ dpc-1840 20 27 showed show VERB dpc-1840 20 28 a a DET dpc-1840 20 29 + + ADJ dpc-1840 20 30 + + ADJ dpc-1840 20 31 + + ADJ dpc-1840 20 32 skin skin NOUN dpc-1840 20 33 reaction reaction NOUN dpc-1840 20 34 to to ADP dpc-1840 20 35 oxacillin oxacillin NOUN dpc-1840 20 36 on on ADP dpc-1840 20 37 day day NOUN dpc-1840 20 38 4 4 NUM dpc-1840 20 39 but but CCONJ dpc-1840 20 40 no no DET dpc-1840 20 41 reaction reaction NOUN dpc-1840 20 42 to to ADP dpc-1840 20 43 tiaprofenic tiaprofenic ADJ dpc-1840 20 44 acid acid NOUN dpc-1840 20 45 . . PUNCT dpc-1840 21 1 all all DET dpc-1840 21 2 penicillins penicillin NOUN dpc-1840 21 3 were be AUX dpc-1840 21 4 prohibited prohibit VERB dpc-1840 21 5 . . PUNCT dpc-1840 22 1 two two NUM dpc-1840 22 2 years year NOUN dpc-1840 22 3 later later ADV dpc-1840 22 4 the the DET dpc-1840 22 5 patient patient NOUN dpc-1840 22 6 presented present VERB dpc-1840 22 7 with with ADP dpc-1840 22 8 a a DET dpc-1840 22 9 similar similar ADJ dpc-1840 22 10 eruption eruption NOUN dpc-1840 22 11 and and CCONJ dpc-1840 22 12 fever fever NOUN dpc-1840 22 13 4 4 NUM dpc-1840 22 14 days day NOUN dpc-1840 22 15 after after ADP dpc-1840 22 16 taking take VERB dpc-1840 22 17 2 2 NUM dpc-1840 22 18 multi multi ADJ dpc-1840 22 19 - - ADJ dpc-1840 22 20 compound compound ADJ dpc-1840 22 21 medications medication NOUN dpc-1840 22 22 named name VERB dpc-1840 22 23 goldix goldix ADJ dpc-1840 22 24 day day NOUN dpc-1840 22 25 ( ( PUNCT dpc-1840 22 26 dextromethorphan dextromethorphan PROPN dpc-1840 22 27 , , PUNCT dpc-1840 22 28 doxylamine doxylamine NOUN dpc-1840 22 29 , , PUNCT dpc-1840 22 30 paracetamol paracetamol NOUN dpc-1840 22 31 ) ) PUNCT dpc-1840 22 32 and and CCONJ dpc-1840 22 33 goldix goldix ADJ dpc-1840 22 34 night night NOUN dpc-1840 22 35 ( ( PUNCT dpc-1840 22 36 dextromethorphan dextromethorphan PROPN dpc-1840 22 37 , , PUNCT dpc-1840 22 38 paracetamol paracetamol NOUN dpc-1840 22 39 , , PUNCT dpc-1840 22 40 phenylephrine phenylephrine NOUN dpc-1840 22 41 ) ) PUNCT dpc-1840 22 42 for for ADP dpc-1840 22 43 a a DET dpc-1840 22 44 cold cold ADJ dpc-1840 22 45 ( ( PUNCT dpc-1840 22 46 figure figure NOUN dpc-1840 22 47 1 1 NUM dpc-1840 22 48 ) ) PUNCT dpc-1840 22 49 . . PUNCT dpc-1840 23 1 she she PRON dpc-1840 23 2 denied deny VERB dpc-1840 23 3 taking take VERB dpc-1840 23 4 any any DET dpc-1840 23 5 other other ADJ dpc-1840 23 6 drug drug NOUN dpc-1840 23 7 . . PUNCT dpc-1840 24 1 complete complete ADJ dpc-1840 24 2 blood blood NOUN dpc-1840 24 3 count count NOUN dpc-1840 24 4 showed show VERB dpc-1840 24 5 2 2 NUM dpc-1840 24 6 research research NOUN dpc-1840 24 7 letter letter NOUN dpc-1840 24 8 | | ADV dpc-1840 24 9 dermatol dermatol ADJ dpc-1840 24 10 pract pract NOUN dpc-1840 24 11 concept concept NOUN dpc-1840 24 12 . . PUNCT dpc-1840 25 1 2022;12(2):e2022058 2022;12(2):e2022058 NUM dpc-1840 25 2 paracetamol paracetamol NOUN dpc-1840 25 3 . . PUNCT dpc-1840 26 1 we we PRON dpc-1840 26 2 performed perform VERB dpc-1840 26 3 a a DET dpc-1840 26 4 genetic genetic ADJ dpc-1840 26 5 analysis analysis NOUN dpc-1840 26 6 to to PART dpc-1840 26 7 determine determine VERB dpc-1840 26 8 whether whether SCONJ dpc-1840 26 9 there there PRON dpc-1840 26 10 was be VERB dpc-1840 26 11 mutation mutation NOUN dpc-1840 26 12 of of ADP dpc-1840 26 13 the the DET dpc-1840 26 14 il36rn il36rn PROPN dpc-1840 26 15 gene gene NOUN dpc-1840 26 16 , , PUNCT dpc-1840 26 17 as as SCONJ dpc-1840 26 18 it it PRON dpc-1840 26 19 may may AUX dpc-1840 26 20 be be AUX dpc-1840 26 21 a a DET dpc-1840 26 22 predisposing predispose VERB dpc-1840 26 23 factor factor NOUN dpc-1840 26 24 , , PUNCT dpc-1840 26 25 but but CCONJ dpc-1840 26 26 we we PRON dpc-1840 26 27 did do AUX dpc-1840 26 28 not not PART dpc-1840 26 29 find find VERB dpc-1840 26 30 such such ADJ dpc-1840 26 31 mutation mutation NOUN dpc-1840 26 32 in in ADP dpc-1840 26 33 our our PRON dpc-1840 26 34 patient patient NOUN dpc-1840 26 35 . . PUNCT dpc-1840 27 1 conclusions conclusion NOUN dpc-1840 27 2 recurrences recurrence VERB dpc-1840 27 3 in in ADP dpc-1840 27 4 agep agep NOUN dpc-1840 27 5 are be AUX dpc-1840 27 6 rare rare ADJ dpc-1840 27 7 and and CCONJ dpc-1840 27 8 often often ADV dpc-1840 27 9 induced induce VERB dpc-1840 27 10 by by ADP dpc-1840 27 11 related related ADJ dpc-1840 27 12 drugs drug NOUN dpc-1840 27 13 , , PUNCT dpc-1840 27 14 mainly mainly ADV dpc-1840 27 15 b b NOUN dpc-1840 27 16 - - PUNCT dpc-1840 27 17 lactams lactam NOUN dpc-1840 27 18 . . PUNCT dpc-1840 28 1 our our PRON dpc-1840 28 2 case case NOUN dpc-1840 28 3 suggests suggest VERB dpc-1840 28 4 that that SCONJ dpc-1840 28 5 it it PRON dpc-1840 28 6 may may AUX dpc-1840 28 7 be be AUX dpc-1840 28 8 induced induce VERB dpc-1840 28 9 by by ADP dpc-1840 28 10 chemically chemically ADV dpc-1840 28 11 different different ADJ dpc-1840 28 12 medications medication NOUN dpc-1840 28 13 in in ADP dpc-1840 28 14 potentially potentially ADV dpc-1840 28 15 predisposed predispose VERB dpc-1840 28 16 patients patient NOUN dpc-1840 28 17 possibly possibly ADV dpc-1840 28 18 having have VERB dpc-1840 28 19 pattern pattern NOUN dpc-1840 28 20 of of ADP dpc-1840 28 21 cytokine cytokine ADJ dpc-1840 28 22 dysregulation dysregulation NOUN dpc-1840 28 23 . . PUNCT dpc-1840 29 1 indeed indeed ADV dpc-1840 29 2 , , PUNCT dpc-1840 29 3 it it PRON dpc-1840 29 4 seems seem VERB dpc-1840 29 5 that that SCONJ dpc-1840 29 6 psoriasis psoriasis NOUN dpc-1840 29 7 might might AUX dpc-1840 29 8 be be AUX dpc-1840 29 9 a a DET dpc-1840 29 10 risk risk NOUN dpc-1840 29 11 factor factor NOUN dpc-1840 29 12 of of ADP dpc-1840 29 13 relapsing relapse VERB dpc-1840 29 14 agep agep NOUN dpc-1840 29 15 . . PUNCT dpc-1840 30 1 we we PRON dpc-1840 30 2 have have AUX dpc-1840 30 3 also also ADV dpc-1840 30 4 shown show VERB dpc-1840 30 5 that that SCONJ dpc-1840 30 6 il36rn il36rn PROPN dpc-1840 30 7 gene gene NOUN dpc-1840 30 8 mutation mutation NOUN dpc-1840 30 9 does do AUX dpc-1840 30 10 not not PART dpc-1840 30 11 fully fully ADV dpc-1840 30 12 explain explain VERB dpc-1840 30 13 the the DET dpc-1840 30 14 pathogenesis pathogenesis NOUN dpc-1840 30 15 of of ADP dpc-1840 30 16 pustular pustular ADJ dpc-1840 30 17 generalized generalized ADJ dpc-1840 30 18 eruptions eruption NOUN dpc-1840 30 19 . . PUNCT dpc-1840 31 1 moreover moreover ADV dpc-1840 31 2 , , PUNCT dpc-1840 31 3 our our PRON dpc-1840 31 4 observation observation NOUN dpc-1840 31 5 is be AUX dpc-1840 31 6 notable notable ADJ dpc-1840 31 7 for for ADP dpc-1840 31 8 the the DET dpc-1840 31 9 implication implication NOUN dpc-1840 31 10 of of ADP dpc-1840 31 11 dextromethorphan dextromethorphan PROPN dpc-1840 31 12 , , PUNCT dpc-1840 31 13 a a DET dpc-1840 31 14 widely widely ADV dpc-1840 31 15 used use VERB dpc-1840 31 16 opioid opioid ADJ dpc-1840 31 17 antitussive antitussive NOUN dpc-1840 31 18 agent agent NOUN dpc-1840 31 19 , , PUNCT dpc-1840 31 20 as as ADP dpc-1840 31 21 a a DET dpc-1840 31 22 culprit culprit NOUN dpc-1840 31 23 drug drug NOUN dpc-1840 31 24 . . PUNCT dpc-1840 32 1 to to ADP dpc-1840 32 2 the the DET dpc-1840 32 3 best good ADJ dpc-1840 32 4 of of ADP dpc-1840 32 5 our our PRON dpc-1840 32 6 knowledge knowledge NOUN dpc-1840 32 7 , , PUNCT dpc-1840 32 8 only only ADV dpc-1840 32 9 1 1 NUM dpc-1840 32 10 case case NOUN dpc-1840 32 11 of of ADP dpc-1840 32 12 agep agep NOUN dpc-1840 32 13 induced induce VERB dpc-1840 32 14 by by ADP dpc-1840 32 15 dextromethorphan dextromethorphan PROPN dpc-1840 32 16 and and CCONJ dpc-1840 32 17 confirmed confirm VERB dpc-1840 32 18 by by ADP dpc-1840 32 19 patch patch NOUN dpc-1840 32 20 testing testing NOUN dpc-1840 32 21 has have AUX dpc-1840 32 22 been be AUX dpc-1840 32 23 previously previously ADV dpc-1840 32 24 reported report VERB dpc-1840 32 25 [ [ X dpc-1840 32 26 2 2 NUM dpc-1840 32 27 ] ] PUNCT dpc-1840 32 28 . . PUNCT dpc-1840 33 1 references reference NOUN dpc-1840 33 2 1 1 NUM dpc-1840 33 3 . . PUNCT dpc-1840 33 4 sidoroff sidoroff PROPN dpc-1840 33 5 a a PRON dpc-1840 33 6 , , PUNCT dpc-1840 33 7 dunant dunant NOUN dpc-1840 33 8 a a NOUN dpc-1840 33 9 , , PUNCT dpc-1840 33 10 viboud viboud ADJ dpc-1840 33 11 c c NOUN dpc-1840 33 12 , , PUNCT dpc-1840 33 13 et et PROPN dpc-1840 33 14 al al PROPN dpc-1840 33 15 . . PUNCT dpc-1840 34 1 risk risk NOUN dpc-1840 34 2 factors factor NOUN dpc-1840 34 3 for for ADP dpc-1840 34 4 acute acute ADJ dpc-1840 34 5 generalized generalize VERB dpc-1840 34 6 exanthematous exanthematous ADJ dpc-1840 34 7 pustulosis pustulosis NOUN dpc-1840 34 8 ( ( PUNCT dpc-1840 34 9 agep)—results agep)—result NOUN dpc-1840 34 10 of of ADP dpc-1840 34 11 a a DET dpc-1840 34 12 multinational multinational ADJ dpc-1840 34 13 case case NOUN dpc-1840 34 14 - - PUNCT dpc-1840 34 15 control control NOUN dpc-1840 34 16 study study NOUN dpc-1840 34 17 ( ( PUNCT dpc-1840 34 18 euroscar euroscar PROPN dpc-1840 34 19 ) ) PUNCT dpc-1840 34 20 . . PUNCT dpc-1840 35 1 br br PROPN dpc-1840 35 2 j j PROPN dpc-1840 35 3 dermatol dermatol NOUN dpc-1840 35 4 . . PUNCT dpc-1840 36 1 2007;157(5):989–996 2007;157(5):989–996 NUM dpc-1840 36 2 . . PUNCT dpc-1840 36 3 doi doi NOUN dpc-1840 36 4 : : PUNCT dpc-1840 36 5 10.1111 10.1111 NUM dpc-1840 36 6 / / SYM dpc-1840 36 7 j.13652133.2007.08156.x j.13652133.2007.08156.x NOUN dpc-1840 36 8 . . PUNCT dpc-1840 37 1 pmid pmid NOUN dpc-1840 37 2 : : PUNCT dpc-1840 37 3 17854366 17854366 NUM dpc-1840 37 4 . . PUNCT dpc-1840 38 1 2 2 X dpc-1840 38 2 . . X dpc-1840 38 3 rashid rashid PROPN dpc-1840 38 4 , , PUNCT dpc-1840 38 5 rs rs NOUN dpc-1840 38 6 , , PUNCT dpc-1840 38 7     SPACE dpc-1840 38 8 ahmed ahme VERB dpc-1840 38 9 , , PUNCT dpc-1840 38 10 i i PRON dpc-1840 38 11 , , PUNCT dpc-1840 38 12     SPACE dpc-1840 38 13 shim shim NOUN dpc-1840 38 14 , , PUNCT dpc-1840 38 15 tn tn PROPN dpc-1840 38 16 . . PUNCT dpc-1840 38 17     SPACE dpc-1840 38 18 acute acute PROPN dpc-1840 38 19 generalized generalize VERB dpc-1840 38 20 exanthematous exanthematous ADJ dpc-1840 38 21 pustulosis pustulosis NOUN dpc-1840 38 22 due due ADP dpc-1840 38 23 to to ADP dpc-1840 38 24 dextromethorphan dextromethorphan PROPN dpc-1840 38 25 . . PUNCT dpc-1840 38 26     SPACE dpc-1840 38 27 contact contact NOUN dpc-1840 38 28 dermatitis dermatitis NOUN dpc-1840 38 29 . . PUNCT dpc-1840 38 30     SPACE dpc-1840 39 1 2020;83(5):424–425 2020;83(5):424–425 NUM dpc-1840 39 2 . . PUNCT dpc-1840 39 3 doi doi NOUN dpc-1840 39 4 : : PUNCT dpc-1840 39 5 10.1111 10.1111 NUM dpc-1840 39 6 / / SYM dpc-1840 39 7 cod.13633 cod.13633 NOUN dpc-1840 39 8 . . PUNCT dpc-1840 40 1 pmid pmid NOUN dpc-1840 40 2 : : PUNCT dpc-1840 40 3 32506524 32506524 NUM dpc-1840 40 4 . . PUNCT dpc-1840 41 1 marked mark VERB dpc-1840 41 2 neutrophilia neutrophilia PROPN dpc-1840 41 3 and and CCONJ dpc-1840 41 4 skin skin NOUN dpc-1840 41 5 biopsy biopsy NOUN dpc-1840 41 6 was be AUX dpc-1840 41 7 consistent consistent ADJ dpc-1840 41 8 with with ADP dpc-1840 41 9 agep agep NOUN dpc-1840 41 10 . . PUNCT dpc-1840 42 1 diagnosis diagnosis NOUN dpc-1840 42 2 was be AUX dpc-1840 42 3 defined define VERB dpc-1840 42 4 following follow VERB dpc-1840 42 5 euroscar euroscar NOUN dpc-1840 42 6 criteria criterion NOUN dpc-1840 42 7 . . PUNCT dpc-1840 43 1 patch patch ADJ dpc-1840 43 2 testing testing NOUN dpc-1840 43 3 with with ADP dpc-1840 43 4 the the DET dpc-1840 43 5 component component NOUN dpc-1840 43 6 of of ADP dpc-1840 43 7 the the DET dpc-1840 43 8 commercialized commercialize VERB dpc-1840 43 9 package package NOUN dpc-1840 43 10 of of ADP dpc-1840 43 11 goldix goldix ADJ dpc-1840 43 12 day day NOUN dpc-1840 43 13 ( ( PUNCT dpc-1840 43 14 30 30 NUM dpc-1840 43 15 % % NOUN dpc-1840 43 16 pet pet NOUN dpc-1840 43 17 . . PUNCT dpc-1840 43 18 ) ) PUNCT dpc-1840 43 19 , , PUNCT dpc-1840 43 20 goldix goldix ADJ dpc-1840 43 21 night night NOUN dpc-1840 43 22 ( ( PUNCT dpc-1840 43 23 30 30 NUM dpc-1840 43 24 % % NOUN dpc-1840 43 25 pet pet NOUN dpc-1840 43 26 . . PUNCT dpc-1840 43 27 ) ) PUNCT dpc-1840 44 1 and and CCONJ dpc-1840 44 2 paracetamol paracetamol NOUN dpc-1840 44 3 ( ( PUNCT dpc-1840 44 4 50 50 NUM dpc-1840 44 5 % % NOUN dpc-1840 44 6 pet pet NOUN dpc-1840 44 7 . . PUNCT dpc-1840 44 8 ) ) PUNCT dpc-1840 44 9 was be AUX dpc-1840 44 10 performed perform VERB dpc-1840 44 11 . . PUNCT dpc-1840 45 1 the the DET dpc-1840 45 2 patch patch PROPN dpc-1840 45 3 test test NOUN dpc-1840 45 4 preparations preparation NOUN dpc-1840 45 5 were be AUX dpc-1840 45 6 applied apply VERB dpc-1840 45 7 in in ADP dpc-1840 45 8 iq iq NOUN dpc-1840 45 9 ultra ultra ADJ dpc-1840 45 10 ( ( PUNCT dpc-1840 45 11 chemotechnique chemotechnique ADJ dpc-1840 45 12 diagnostics diagnostic NOUN dpc-1840 45 13 ) ) PUNCT dpc-1840 45 14 . . PUNCT dpc-1840 46 1 the the DET dpc-1840 46 2 patch patch NOUN dpc-1840 46 3 tests test NOUN dpc-1840 46 4 were be AUX dpc-1840 46 5 occluded occlude VERB dpc-1840 46 6 for for ADP dpc-1840 46 7 48 48 NUM dpc-1840 46 8 hours hour NOUN dpc-1840 46 9 , , PUNCT dpc-1840 46 10 and and CCONJ dpc-1840 46 11 readings reading NOUN dpc-1840 46 12 were be AUX dpc-1840 46 13 performed perform VERB dpc-1840 46 14 according accord VERB dpc-1840 46 15 to to ADP dpc-1840 46 16 icdrg icdrg ADJ dpc-1840 46 17 / / SYM dpc-1840 46 18 escd escd NOUN dpc-1840 46 19 criteria criterion NOUN dpc-1840 46 20 on on ADP dpc-1840 46 21 day day NOUN dpc-1840 46 22 2 2 NUM dpc-1840 46 23 and and CCONJ dpc-1840 46 24 day day NOUN dpc-1840 46 25 4 4 NUM dpc-1840 46 26 . . PUNCT dpc-1840 46 27 patch patch NOUN dpc-1840 46 28 testing testing NOUN dpc-1840 46 29 showed show VERB dpc-1840 46 30 a a DET dpc-1840 46 31 + + ADJ dpc-1840 46 32 + + ADJ dpc-1840 46 33 skin skin NOUN dpc-1840 46 34 reaction reaction NOUN dpc-1840 46 35 to to ADP dpc-1840 46 36 goldix goldix ADJ dpc-1840 46 37 day day NOUN dpc-1840 46 38 and and CCONJ dpc-1840 46 39 goldix goldix ADJ dpc-1840 46 40 night night NOUN dpc-1840 46 41 , , PUNCT dpc-1840 46 42 but but CCONJ dpc-1840 46 43 was be AUX dpc-1840 46 44 negative negative ADJ dpc-1840 46 45 to to ADP dpc-1840 46 46 paracetamol paracetamol NOUN dpc-1840 46 47 ( ( PUNCT dpc-1840 46 48 figure figure NOUN dpc-1840 46 49 2 2 NUM dpc-1840 46 50 ) ) PUNCT dpc-1840 46 51 . . PUNCT dpc-1840 47 1 the the DET dpc-1840 47 2 oral oral ADJ dpc-1840 47 3 provocation provocation NOUN dpc-1840 47 4 test test NOUN dpc-1840 47 5 to to ADP dpc-1840 47 6 paracetamol paracetamol NOUN dpc-1840 47 7 was be AUX dpc-1840 47 8 also also ADV dpc-1840 47 9 negative negative ADJ dpc-1840 47 10 . . PUNCT dpc-1840 48 1 the the DET dpc-1840 48 2 constituent constituent NOUN dpc-1840 48 3 dextromethorphan dextromethorphan NOUN dpc-1840 48 4 was be AUX dpc-1840 48 5 not not PART dpc-1840 48 6 available available ADJ dpc-1840 48 7 for for ADP dpc-1840 48 8 testing testing NOUN dpc-1840 48 9 , , PUNCT dpc-1840 48 10 but but CCONJ dpc-1840 48 11 was be AUX dpc-1840 48 12 suspected suspect VERB dpc-1840 48 13 as as ADP dpc-1840 48 14 the the DET dpc-1840 48 15 cause cause NOUN dpc-1840 48 16 of of ADP dpc-1840 48 17 the the DET dpc-1840 48 18 reaction reaction NOUN dpc-1840 48 19 as as SCONJ dpc-1840 48 20 it it PRON dpc-1840 48 21 was be AUX dpc-1840 48 22 the the DET dpc-1840 48 23 only only ADJ dpc-1840 48 24 compound compound NOUN dpc-1840 48 25 in in ADP dpc-1840 48 26 common common ADJ dpc-1840 48 27 besides besides SCONJ dpc-1840 48 28 figure figure NOUN dpc-1840 48 29 1 1 NUM dpc-1840 48 30 . . PUNCT dpc-1840 49 1 diffuse diffuse VERB dpc-1840 49 2 erythema erythema NOUN dpc-1840 49 3 with with ADP dpc-1840 49 4 multiple multiple ADJ dpc-1840 49 5 small small ADJ dpc-1840 49 6 pustules pustule NOUN dpc-1840 49 7 . . PUNCT dpc-1840 50 1 figure figure NOUN dpc-1840 50 2 2 2 NUM dpc-1840 50 3 . . PUNCT dpc-1840 51 1 ( ( PUNCT dpc-1840 51 2 a a X dpc-1840 51 3 ) ) PUNCT dpc-1840 51 4 positive positive ADJ dpc-1840 51 5 patch patch NOUN dpc-1840 51 6 test test NOUN dpc-1840 51 7 reaction reaction NOUN dpc-1840 51 8 to to ADP dpc-1840 51 9 goldix goldix ADJ dpc-1840 51 10 day day NOUN dpc-1840 51 11 on on ADP dpc-1840 51 12 day day NOUN dpc-1840 51 13 4 4 NUM dpc-1840 51 14 . . PUNCT dpc-1840 52 1 ( ( PUNCT dpc-1840 52 2 b b X dpc-1840 52 3 ) ) PUNCT dpc-1840 52 4 positive positive ADJ dpc-1840 52 5 patch patch NOUN dpc-1840 52 6 test test NOUN dpc-1840 52 7 reaction reaction NOUN dpc-1840 52 8 to to ADP dpc-1840 52 9 goldix goldix ADJ dpc-1840 52 10 night night NOUN dpc-1840 52 11 on on ADP dpc-1840 52 12 day day NOUN dpc-1840 52 13 4 4 NUM dpc-1840 52 14 . . PUNCT dpc-1840 53 1 ( ( PUNCT dpc-1840 53 2 c c X dpc-1840 53 3 ) ) PUNCT dpc-1840 53 4 no no DET dpc-1840 53 5 reactions reaction NOUN dpc-1840 53 6 to to ADP dpc-1840 53 7 paracetamol paracetamol PROPN dpc-1840 53 8 were be AUX dpc-1840 53 9 seen see VERB dpc-1840 53 10 on on ADP dpc-1840 53 11 day day NOUN dpc-1840 53 12 4 4 NUM dpc-1840 53 13 . . PUNCT