id	sid	tid	token	lemma	pos
dpc-2859	1	1	dermatology	dermatology	NOUN
dpc-2859	1	2	:	:	PUNCT
dpc-2859	1	3	practical	practical	ADJ
dpc-2859	1	4	and	and	CCONJ
dpc-2859	1	5	conceptual	conceptual	ADJ
dpc-2859	1	6	original	original	ADJ
dpc-2859	1	7	article	article	NOUN
dpc-2859	1	8	|	|	ADV
dpc-2859	1	9	dermatol	dermatol	ADJ
dpc-2859	1	10	pract	pract	NOUN
dpc-2859	1	11	concept	concept	NOUN
dpc-2859	1	12	.	.	PUNCT
dpc-2859	2	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	2	2	1	1	NUM
dpc-2859	2	3	evaluation	evaluation	NOUN
dpc-2859	2	4	of	of	ADP
dpc-2859	2	5	the	the	DET
dpc-2859	2	6	incidence	incidence	NOUN
dpc-2859	2	7	of	of	ADP
dpc-2859	2	8	anal	anal	ADJ
dpc-2859	2	9	fissures	fissure	NOUN
dpc-2859	2	10	in	in	ADP
dpc-2859	2	11	patients	patient	NOUN
dpc-2859	2	12	 	 	SPACE
dpc-2859	2	13	who	who	PRON
dpc-2859	2	14	 	 	SPACE
dpc-2859	2	15	systemic	systemic	ADJ
dpc-2859	2	16	isotretinoin	isotretinoin	PROPN
dpc-2859	2	17	therapy	therapy	NOUN
dpc-2859	2	18	for	for	ADP
dpc-2859	2	19	acne	acne	PROPN
dpc-2859	2	20	hamza	hamza	PROPN
dpc-2859	2	21	aktas1	aktas1	PROPN
dpc-2859	2	22	,	,	PUNCT
dpc-2859	2	23	zeynep	zeynep	NOUN
dpc-2859	2	24	şener	şener	NOUN
dpc-2859	2	25	bahçe2	bahçe2	NOUN
dpc-2859	2	26	1	1	NUM
dpc-2859	2	27	private	private	ADJ
dpc-2859	2	28	memorial	memorial	ADJ
dpc-2859	2	29	hospital	hospital	NOUN
dpc-2859	2	30	,	,	PUNCT
dpc-2859	2	31	department	department	NOUN
dpc-2859	2	32	of	of	ADP
dpc-2859	2	33	dermatology	dermatology	NOUN
dpc-2859	2	34	,	,	PUNCT
dpc-2859	2	35	diyarbakır	diyarbakır	PROPN
dpc-2859	2	36	,	,	PUNCT
dpc-2859	2	37	turkey	turkey	NOUN
dpc-2859	2	38	2	2	NUM
dpc-2859	2	39	private	private	ADJ
dpc-2859	2	40	memorial	memorial	ADJ
dpc-2859	2	41	hospital	hospital	NOUN
dpc-2859	2	42	,	,	PUNCT
dpc-2859	2	43	department	department	NOUN
dpc-2859	2	44	of	of	ADP
dpc-2859	2	45	general	general	ADJ
dpc-2859	2	46	surgery	surgery	NOUN
dpc-2859	2	47	,	,	PUNCT
dpc-2859	2	48	diyarbakır	diyarbakır	PROPN
dpc-2859	2	49	,	,	PUNCT
dpc-2859	2	50	turkey	turkey	NOUN
dpc-2859	2	51	key	key	ADJ
dpc-2859	2	52	words	word	NOUN
dpc-2859	2	53	:	:	PUNCT
dpc-2859	2	54	acne	acne	NOUN
dpc-2859	2	55	vulgaris	vulgaris	NOUN
dpc-2859	2	56	,	,	PUNCT
dpc-2859	2	57	isotretinoin	isotretinoin	PROPN
dpc-2859	2	58	,	,	PUNCT
dpc-2859	2	59	adverse	adverse	ADJ
dpc-2859	2	60	events	event	NOUN
dpc-2859	2	61	,	,	PUNCT
dpc-2859	2	62	anal	anal	ADJ
dpc-2859	2	63	fissure	fissure	NOUN
dpc-2859	2	64	,	,	PUNCT
dpc-2859	2	65	constipation	constipation	NOUN
dpc-2859	2	66	citation	citation	NOUN
dpc-2859	2	67	:	:	PUNCT
dpc-2859	2	68	aktaş	aktaş	PROPN
dpc-2859	2	69	h	h	NOUN
dpc-2859	2	70	,	,	PUNCT
dpc-2859	2	71	şener	şener	ADJ
dpc-2859	2	72	bahçe	bahçe	PROPN
dpc-2859	2	73	z.	z.	PROPN
dpc-2859	2	74	evaluation	evaluation	NOUN
dpc-2859	2	75	of	of	ADP
dpc-2859	2	76	the	the	DET
dpc-2859	2	77	incidence	incidence	NOUN
dpc-2859	2	78	of	of	ADP
dpc-2859	2	79	anal	anal	ADJ
dpc-2859	2	80	fissures	fissure	NOUN
dpc-2859	2	81	in	in	ADP
dpc-2859	2	82	patients	patient	NOUN
dpc-2859	2	83	who	who	PRON
dpc-2859	2	84	systemic	systemic	ADJ
dpc-2859	2	85	isotretinoin	isotretinoin	PROPN
dpc-2859	2	86	therapy	therapy	NOUN
dpc-2859	2	87	for	for	ADP
dpc-2859	2	88	acne	acne	NOUN
dpc-2859	2	89	.	.	PUNCT
dpc-2859	3	1	dermatol	dermatol	NOUN
dpc-2859	3	2	pract	pract	PROPN
dpc-2859	3	3	concept	concept	NOUN
dpc-2859	3	4	.	.	PUNCT
dpc-2859	4	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	4	2	.	.	PUNCT
dpc-2859	5	1	doi	doi	NOUN
dpc-2859	5	2	:	:	PUNCT
dpc-2859	5	3	https://doi.org/10.5826/dpc.1303a133	https://doi.org/10.5826/dpc.1303a133	PROPN
dpc-2859	5	4	accepted	accept	VERB
dpc-2859	5	5	:	:	PUNCT
dpc-2859	5	6	january	january	PROPN
dpc-2859	5	7	11	11	NUM
dpc-2859	5	8	,	,	PUNCT
dpc-2859	5	9	2023	2023	NUM
dpc-2859	5	10	;	;	PUNCT
dpc-2859	5	11	published	publish	VERB
dpc-2859	5	12	:	:	PUNCT
dpc-2859	6	1	july	july	PROPN
dpc-2859	6	2	2023	2023	NUM
dpc-2859	6	3	copyright	copyright	NOUN
dpc-2859	6	4	:	:	PUNCT
dpc-2859	6	5	©	©	PROPN
dpc-2859	6	6	2023	2023	NUM
dpc-2859	6	7	aktaş	aktaş	NOUN
dpc-2859	6	8	et	et	PROPN
dpc-2859	6	9	al	al	PROPN
dpc-2859	6	10	.	.	PUNCT
dpc-2859	7	1	this	this	PRON
dpc-2859	7	2	is	be	AUX
dpc-2859	7	3	an	an	DET
dpc-2859	7	4	open	open	ADJ
dpc-2859	7	5	-	-	PUNCT
dpc-2859	7	6	access	access	NOUN
dpc-2859	7	7	article	article	NOUN
dpc-2859	7	8	distributed	distribute	VERB
dpc-2859	7	9	under	under	ADP
dpc-2859	7	10	the	the	DET
dpc-2859	7	11	terms	term	NOUN
dpc-2859	7	12	of	of	ADP
dpc-2859	7	13	the	the	DET
dpc-2859	7	14	creative	creative	ADJ
dpc-2859	7	15	commons	common	NOUN
dpc-2859	7	16	attribution	attribution	NOUN
dpc-2859	7	17	-	-	PUNCT
dpc-2859	7	18	noncommercial	noncommercial	ADJ
dpc-2859	7	19	license	license	NOUN
dpc-2859	7	20	(	(	PUNCT
dpc-2859	7	21	by	by	ADP
dpc-2859	7	22	-	-	PUNCT
dpc-2859	7	23	nc-4.0	nc-4.0	NOUN
dpc-2859	7	24	)	)	PUNCT
dpc-2859	7	25	,	,	PUNCT
dpc-2859	7	26	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-2859	7	27	,	,	PUNCT
dpc-2859	7	28	which	which	PRON
dpc-2859	7	29	permits	permit	VERB
dpc-2859	7	30	unrestricted	unrestricted	ADJ
dpc-2859	7	31	noncommercial	noncommercial	ADJ
dpc-2859	7	32	use	use	NOUN
dpc-2859	7	33	,	,	PUNCT
dpc-2859	7	34	distribution	distribution	NOUN
dpc-2859	7	35	,	,	PUNCT
dpc-2859	7	36	and	and	CCONJ
dpc-2859	7	37	reproduction	reproduction	NOUN
dpc-2859	7	38	in	in	ADP
dpc-2859	7	39	any	any	DET
dpc-2859	7	40	medium	medium	NOUN
dpc-2859	7	41	,	,	PUNCT
dpc-2859	7	42	provided	provide	VERB
dpc-2859	7	43	the	the	DET
dpc-2859	7	44	original	original	ADJ
dpc-2859	7	45	authors	author	NOUN
dpc-2859	7	46	and	and	CCONJ
dpc-2859	7	47	source	source	NOUN
dpc-2859	7	48	are	be	AUX
dpc-2859	7	49	credited	credit	VERB
dpc-2859	7	50	.	.	PUNCT
dpc-2859	8	1	funding	funding	NOUN
dpc-2859	8	2	:	:	PUNCT
dpc-2859	8	3	none	none	NOUN
dpc-2859	8	4	.	.	PUNCT
dpc-2859	9	1	competing	compete	VERB
dpc-2859	9	2	interests	interest	NOUN
dpc-2859	9	3	:	:	PUNCT
dpc-2859	9	4	none	none	NOUN
dpc-2859	9	5	.	.	PUNCT
dpc-2859	10	1	authorship	authorship	NOUN
dpc-2859	10	2	:	:	PUNCT
dpc-2859	10	3	all	all	DET
dpc-2859	10	4	authors	author	NOUN
dpc-2859	10	5	have	have	AUX
dpc-2859	10	6	contributed	contribute	VERB
dpc-2859	10	7	significantly	significantly	ADV
dpc-2859	10	8	to	to	ADP
dpc-2859	10	9	this	this	DET
dpc-2859	10	10	publication	publication	NOUN
dpc-2859	10	11	.	.	PUNCT
dpc-2859	11	1	corresponding	correspond	VERB
dpc-2859	11	2	author	author	NOUN
dpc-2859	11	3	:	:	PUNCT
dpc-2859	11	4	hamza	hamza	PROPN
dpc-2859	11	5	aktaş	aktaş	PROPN
dpc-2859	11	6	,	,	PUNCT
dpc-2859	11	7	private	private	ADJ
dpc-2859	11	8	memorial	memorial	ADJ
dpc-2859	11	9	hospital	hospital	NOUN
dpc-2859	11	10	,	,	PUNCT
dpc-2859	11	11	department	department	NOUN
dpc-2859	11	12	of	of	ADP
dpc-2859	11	13	dermatology	dermatology	NOUN
dpc-2859	11	14	,	,	PUNCT
dpc-2859	11	15	fırat	fırat	PROPN
dpc-2859	11	16	bulvarı	bulvarı	PROPN
dpc-2859	11	17	peyas	peyas	PROPN
dpc-2859	11	18	mahallesi	mahallesi	PROPN
dpc-2859	11	19	no:12	no:12	PROPN
dpc-2859	11	20	,	,	PUNCT
dpc-2859	11	21	21080	21080	NUM
dpc-2859	11	22	kayapınar	kayapınar	NOUN
dpc-2859	11	23	/	/	SYM
dpc-2859	11	24	diyarbakır	diyarbakır	PROPN
dpc-2859	11	25	,	,	PUNCT
dpc-2859	11	26	turkey	turkey	PROPN
dpc-2859	11	27	.	.	PUNCT
dpc-2859	12	1	tel	tel	ADP
dpc-2859	12	2	:	:	PUNCT
dpc-2859	12	3	0505	0505	NUM
dpc-2859	12	4	6685239	6685239	NUM
dpc-2859	12	5	fax	fax	NOUN
dpc-2859	12	6	:	:	PUNCT
dpc-2859	12	7	+90	+90	NOUN
dpc-2859	12	8	0412	0412	NUM
dpc-2859	12	9	314	314	NUM
dpc-2859	12	10	66	66	NUM
dpc-2859	12	11	17	17	NUM
dpc-2859	12	12	e	e	NOUN
dpc-2859	12	13	-	-	NOUN
dpc-2859	12	14	mail	mail	NOUN
dpc-2859	12	15	:	:	PUNCT
dpc-2859	13	1	drhamzaaktas21@gmail.com	drhamzaaktas21@gmail.com	X
dpc-2859	13	2	introduction	introduction	NOUN
dpc-2859	13	3	:	:	PUNCT
dpc-2859	13	4	isotretinoin	isotretinoin	PROPN
dpc-2859	13	5	is	be	AUX
dpc-2859	13	6	an	an	DET
dpc-2859	13	7	effective	effective	ADJ
dpc-2859	13	8	drug	drug	NOUN
dpc-2859	13	9	widely	widely	ADV
dpc-2859	13	10	used	use	VERB
dpc-2859	13	11	in	in	ADP
dpc-2859	13	12	the	the	DET
dpc-2859	13	13	treatment	treatment	NOUN
dpc-2859	13	14	of	of	ADP
dpc-2859	13	15	severe	severe	ADJ
dpc-2859	13	16	acne	acne	NOUN
dpc-2859	13	17	.	.	PUNCT
dpc-2859	14	1	in	in	ADP
dpc-2859	14	2	this	this	DET
dpc-2859	14	3	study	study	NOUN
dpc-2859	14	4	,	,	PUNCT
dpc-2859	14	5	we	we	PRON
dpc-2859	14	6	tried	try	VERB
dpc-2859	14	7	to	to	PART
dpc-2859	14	8	evaluate	evaluate	VERB
dpc-2859	14	9	the	the	DET
dpc-2859	14	10	incidence	incidence	NOUN
dpc-2859	14	11	of	of	ADP
dpc-2859	14	12	anal	anal	ADJ
dpc-2859	14	13	fissures	fissure	NOUN
dpc-2859	14	14	with	with	ADP
dpc-2859	14	15	clinical	clinical	ADJ
dpc-2859	14	16	and	and	CCONJ
dpc-2859	14	17	laboratory	laboratory	NOUN
dpc-2859	14	18	side	side	NOUN
dpc-2859	14	19	effects	effect	NOUN
dpc-2859	14	20	associated	associate	VERB
dpc-2859	14	21	with	with	ADP
dpc-2859	14	22	isotretinoin	isotretinoin	PROPN
dpc-2859	14	23	.	.	PUNCT
dpc-2859	15	1	methods	method	NOUN
dpc-2859	15	2	:	:	PUNCT
dpc-2859	15	3	the	the	DET
dpc-2859	15	4	study	study	NOUN
dpc-2859	15	5	evaluated	evaluate	VERB
dpc-2859	15	6	210	210	NUM
dpc-2859	15	7	patients	patient	NOUN
dpc-2859	15	8	who	who	PRON
dpc-2859	15	9	received	receive	VERB
dpc-2859	15	10	systemic	systemic	ADJ
dpc-2859	15	11	isotretinoin	isotretinoin	PROPN
dpc-2859	15	12	treatment	treatment	NOUN
dpc-2859	15	13	.	.	PUNCT
dpc-2859	16	1	especially	especially	ADV
dpc-2859	16	2	patients	patient	NOUN
dpc-2859	16	3	with	with	ADP
dpc-2859	16	4	constipation	constipation	NOUN
dpc-2859	16	5	and	and	CCONJ
dpc-2859	16	6	anal	anal	ADJ
dpc-2859	16	7	bleeding	bleeding	NOUN
dpc-2859	16	8	were	be	AUX
dpc-2859	16	9	evaluated	evaluate	VERB
dpc-2859	16	10	by	by	ADP
dpc-2859	16	11	the	the	DET
dpc-2859	16	12	general	general	ADJ
dpc-2859	16	13	surgery	surgery	NOUN
dpc-2859	16	14	clinic	clinic	NOUN
dpc-2859	16	15	to	to	PART
dpc-2859	16	16	arrange	arrange	VERB
dpc-2859	16	17	appropriate	appropriate	ADJ
dpc-2859	16	18	treatments	treatment	NOUN
dpc-2859	16	19	.	.	PUNCT
dpc-2859	17	1	results	result	NOUN
dpc-2859	17	2	:	:	PUNCT
dpc-2859	17	3	of	of	ADP
dpc-2859	17	4	210	210	NUM
dpc-2859	17	5	patients	patient	NOUN
dpc-2859	17	6	included	include	VERB
dpc-2859	17	7	in	in	ADP
dpc-2859	17	8	the	the	DET
dpc-2859	17	9	study	study	NOUN
dpc-2859	17	10	,	,	PUNCT
dpc-2859	17	11	138	138	NUM
dpc-2859	17	12	(	(	PUNCT
dpc-2859	17	13	65.7	65.7	NUM
dpc-2859	17	14	%	%	NOUN
dpc-2859	17	15	)	)	PUNCT
dpc-2859	17	16	were	be	AUX
dpc-2859	17	17	female	female	ADJ
dpc-2859	17	18	and	and	CCONJ
dpc-2859	17	19	72	72	NUM
dpc-2859	17	20	(	(	PUNCT
dpc-2859	17	21	34.3	34.3	NUM
dpc-2859	17	22	%	%	NOUN
dpc-2859	17	23	)	)	PUNCT
dpc-2859	17	24	were	be	AUX
dpc-2859	17	25	male	male	ADJ
dpc-2859	17	26	,	,	PUNCT
dpc-2859	17	27	with	with	ADP
dpc-2859	17	28	a	a	DET
dpc-2859	17	29	mean	mean	ADJ
dpc-2859	17	30	age	age	NOUN
dpc-2859	17	31	of	of	ADP
dpc-2859	17	32	23.7	23.7	NUM
dpc-2859	17	33	years	year	NOUN
dpc-2859	17	34	.	.	PUNCT
dpc-2859	18	1	the	the	DET
dpc-2859	18	2	most	most	ADV
dpc-2859	18	3	common	common	ADJ
dpc-2859	18	4	adverse	adverse	ADJ
dpc-2859	18	5	event	event	NOUN
dpc-2859	18	6	was	be	AUX
dpc-2859	18	7	dry	dry	ADJ
dpc-2859	18	8	lips	lip	NOUN
dpc-2859	18	9	in	in	ADP
dpc-2859	18	10	206	206	NUM
dpc-2859	18	11	(	(	PUNCT
dpc-2859	18	12	98.1	98.1	NUM
dpc-2859	18	13	%	%	NOUN
dpc-2859	18	14	)	)	PUNCT
dpc-2859	18	15	patients	patient	NOUN
dpc-2859	18	16	.	.	PUNCT
dpc-2859	19	1	the	the	DET
dpc-2859	19	2	mucocutaneous	mucocutaneous	ADJ
dpc-2859	19	3	side	side	NOUN
dpc-2859	19	4	effects	effect	NOUN
dpc-2859	19	5	were	be	AUX
dpc-2859	19	6	constipation	constipation	NOUN
dpc-2859	19	7	36	36	NUM
dpc-2859	19	8	(	(	PUNCT
dpc-2859	19	9	17.1	17.1	NUM
dpc-2859	19	10	%	%	NOUN
dpc-2859	19	11	)	)	PUNCT
dpc-2859	19	12	,	,	PUNCT
dpc-2859	19	13	anal	anal	ADJ
dpc-2859	19	14	bleeding	bleed	VERB
dpc-2859	19	15	18	18	NUM
dpc-2859	19	16	(	(	PUNCT
dpc-2859	19	17	8.6	8.6	NUM
dpc-2859	19	18	%	%	NOUN
dpc-2859	19	19	)	)	PUNCT
dpc-2859	19	20	,	,	PUNCT
dpc-2859	19	21	mucosal	mucosal	NOUN
dpc-2859	19	22	erosion	erosion	NOUN
dpc-2859	19	23	10	10	NUM
dpc-2859	19	24	(	(	PUNCT
dpc-2859	19	25	4.7	4.7	NUM
dpc-2859	19	26	%	%	NOUN
dpc-2859	19	27	)	)	PUNCT
dpc-2859	19	28	,	,	PUNCT
dpc-2859	19	29	anal	anal	ADJ
dpc-2859	19	30	fissure	fissure	NOUN
dpc-2859	19	31	7	7	NUM
dpc-2859	19	32	(	(	PUNCT
dpc-2859	19	33	3.3	3.3	NUM
dpc-2859	19	34	%	%	NOUN
dpc-2859	19	35	)	)	PUNCT
dpc-2859	19	36	.	.	PUNCT
dpc-2859	20	1	treatment	treatment	NOUN
dpc-2859	20	2	was	be	AUX
dpc-2859	20	3	discontinued	discontinue	VERB
dpc-2859	20	4	due	due	ADJ
dpc-2859	20	5	to	to	ADP
dpc-2859	20	6	elevated	elevated	ADJ
dpc-2859	20	7	liver	liver	NOUN
dpc-2859	20	8	function	function	NOUN
dpc-2859	20	9	tests	test	NOUN
dpc-2859	20	10	in	in	ADP
dpc-2859	20	11	5	5	NUM
dpc-2859	20	12	patients	patient	NOUN
dpc-2859	20	13	(	(	PUNCT
dpc-2859	20	14	2.3	2.3	NUM
dpc-2859	20	15	%	%	NOUN
dpc-2859	20	16	)	)	PUNCT
dpc-2859	20	17	,	,	PUNCT
dpc-2859	20	18	and	and	CCONJ
dpc-2859	20	19	because	because	SCONJ
dpc-2859	20	20	anal	anal	ADJ
dpc-2859	20	21	bleeding	bleeding	NOUN
dpc-2859	20	22	could	could	AUX
dpc-2859	20	23	not	not	PART
dpc-2859	20	24	be	be	AUX
dpc-2859	20	25	controlled	control	VERB
dpc-2859	20	26	in	in	ADP
dpc-2859	20	27	1	1	NUM
dpc-2859	20	28	patient	patient	NOUN
dpc-2859	20	29	.	.	PUNCT
dpc-2859	21	1	conclusions	conclusion	NOUN
dpc-2859	21	2	:	:	PUNCT
dpc-2859	21	3	isotretinoin	isotretinoin	PROPN
dpc-2859	21	4	is	be	AUX
dpc-2859	21	5	the	the	DET
dpc-2859	21	6	most	most	ADV
dpc-2859	21	7	effective	effective	ADJ
dpc-2859	21	8	acne	acne	NOUN
dpc-2859	21	9	medicine	medicine	NOUN
dpc-2859	21	10	used	use	VERB
dpc-2859	21	11	today	today	NOUN
dpc-2859	21	12	.	.	PUNCT
dpc-2859	22	1	clarification	clarification	NOUN
dpc-2859	22	2	of	of	ADP
dpc-2859	22	3	the	the	DET
dpc-2859	22	4	patients	patient	NOUN
dpc-2859	22	5	about	about	ADP
dpc-2859	22	6	the	the	DET
dpc-2859	22	7	rarely	rarely	ADV
dpc-2859	22	8	seen	see	VERB
dpc-2859	22	9	side	side	NOUN
dpc-2859	22	10	effects	effect	NOUN
dpc-2859	22	11	such	such	ADJ
dpc-2859	22	12	as	as	ADP
dpc-2859	22	13	dryness	dryness	NOUN
dpc-2859	22	14	,	,	PUNCT
dpc-2859	22	15	erosion	erosion	NOUN
dpc-2859	22	16	,	,	PUNCT
dpc-2859	22	17	fissure	fissure	NOUN
dpc-2859	22	18	and	and	CCONJ
dpc-2859	22	19	bleeding	bleed	VERB
dpc-2859	22	20	in	in	ADP
dpc-2859	22	21	the	the	DET
dpc-2859	22	22	anal	anal	ADJ
dpc-2859	22	23	mucosa	mucosa	NOUN
dpc-2859	22	24	in	in	ADP
dpc-2859	22	25	addition	addition	NOUN
dpc-2859	22	26	to	to	ADP
dpc-2859	22	27	the	the	DET
dpc-2859	22	28	common	common	ADJ
dpc-2859	22	29	mucocutaneous	mucocutaneous	ADJ
dpc-2859	22	30	side	side	NOUN
dpc-2859	22	31	effects	effect	NOUN
dpc-2859	22	32	will	will	AUX
dpc-2859	22	33	ensure	ensure	VERB
dpc-2859	22	34	that	that	SCONJ
dpc-2859	22	35	patients	patient	NOUN
dpc-2859	22	36	are	be	AUX
dpc-2859	22	37	more	more	ADV
dpc-2859	22	38	cautious	cautious	ADJ
dpc-2859	22	39	and	and	CCONJ
dpc-2859	22	40	increase	increase	VERB
dpc-2859	22	41	their	their	PRON
dpc-2859	22	42	tolerance	tolerance	NOUN
dpc-2859	22	43	to	to	ADP
dpc-2859	22	44	the	the	DET
dpc-2859	22	45	treatment	treatment	NOUN
dpc-2859	22	46	.	.	PUNCT
dpc-2859	23	1	abstract	abstract	ADJ
dpc-2859	23	2	2	2	NUM
dpc-2859	23	3	original	original	ADJ
dpc-2859	23	4	article	article	NOUN
dpc-2859	23	5	|	|	ADV
dpc-2859	23	6	dermatol	dermatol	ADJ
dpc-2859	23	7	pract	pract	NOUN
dpc-2859	23	8	concept	concept	NOUN
dpc-2859	23	9	.	.	PUNCT
dpc-2859	24	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	24	2	introduction	introduction	NOUN
dpc-2859	24	3	acne	acne	NOUN
dpc-2859	24	4	vulgaris	vulgaris	NOUN
dpc-2859	24	5	is	be	AUX
dpc-2859	24	6	a	a	DET
dpc-2859	24	7	multifactorial	multifactorial	ADJ
dpc-2859	24	8	disease	disease	NOUN
dpc-2859	24	9	of	of	ADP
dpc-2859	24	10	the	the	DET
dpc-2859	24	11	pilosebaceous	pilosebaceous	ADJ
dpc-2859	24	12	unit	unit	NOUN
dpc-2859	24	13	that	that	PRON
dpc-2859	24	14	affects	affect	VERB
dpc-2859	24	15	millions	million	NOUN
dpc-2859	24	16	of	of	ADP
dpc-2859	24	17	people	people	NOUN
dpc-2859	24	18	around	around	ADP
dpc-2859	24	19	the	the	DET
dpc-2859	24	20	world	world	NOUN
dpc-2859	24	21	to	to	ADP
dpc-2859	24	22	varying	vary	VERB
dpc-2859	24	23	degrees	degree	NOUN
dpc-2859	24	24	.	.	PUNCT
dpc-2859	25	1	it	it	PRON
dpc-2859	25	2	affects	affect	VERB
dpc-2859	25	3	about	about	ADP
dpc-2859	25	4	85	85	NUM
dpc-2859	25	5	%	%	NOUN
dpc-2859	25	6	of	of	ADP
dpc-2859	25	7	the	the	DET
dpc-2859	25	8	young	young	ADJ
dpc-2859	25	9	population	population	NOUN
dpc-2859	25	10	.	.	PUNCT
dpc-2859	26	1	although	although	SCONJ
dpc-2859	26	2	it	it	PRON
dpc-2859	26	3	is	be	AUX
dpc-2859	26	4	primarily	primarily	ADV
dpc-2859	26	5	a	a	DET
dpc-2859	26	6	disease	disease	NOUN
dpc-2859	26	7	of	of	ADP
dpc-2859	26	8	the	the	DET
dpc-2859	26	9	adolescent	adolescent	ADJ
dpc-2859	26	10	period	period	NOUN
dpc-2859	26	11	,	,	PUNCT
dpc-2859	26	12	we	we	PRON
dpc-2859	26	13	observe	observe	VERB
dpc-2859	26	14	it	it	PRON
dpc-2859	26	15	in	in	ADP
dpc-2859	26	16	neonatal	neonatal	ADJ
dpc-2859	26	17	and	and	CCONJ
dpc-2859	26	18	infancy	infancy	NOUN
dpc-2859	26	19	periods	period	NOUN
dpc-2859	26	20	,	,	PUNCT
dpc-2859	26	21	as	as	ADV
dpc-2859	26	22	well	well	ADV
dpc-2859	26	23	as	as	ADP
dpc-2859	26	24	prepubertal	prepubertal	ADJ
dpc-2859	26	25	period	period	NOUN
dpc-2859	26	26	and	and	CCONJ
dpc-2859	26	27	advanced	advanced	ADJ
dpc-2859	26	28	age	age	NOUN
dpc-2859	26	29	patients	patient	NOUN
dpc-2859	26	30	[	[	X
dpc-2859	26	31	1	1	NUM
dpc-2859	26	32	-	-	SYM
dpc-2859	26	33	3	3	NUM
dpc-2859	26	34	]	]	PUNCT
dpc-2859	26	35	.	.	PUNCT
dpc-2859	27	1	primary	primary	ADJ
dpc-2859	27	2	pathogenic	pathogenic	ADJ
dpc-2859	27	3	factors	factor	NOUN
dpc-2859	27	4	of	of	ADP
dpc-2859	27	5	acne	acne	NOUN
dpc-2859	27	6	are	be	AUX
dpc-2859	27	7	increased	increase	VERB
dpc-2859	27	8	sebum	sebum	NOUN
dpc-2859	27	9	production	production	NOUN
dpc-2859	27	10	,	,	PUNCT
dpc-2859	27	11	changes	change	NOUN
dpc-2859	27	12	in	in	ADP
dpc-2859	27	13	keratinization	keratinization	NOUN
dpc-2859	27	14	process	process	NOUN
dpc-2859	27	15	,	,	PUNCT
dpc-2859	27	16	follicular	follicular	ADJ
dpc-2859	27	17	colonization	colonization	NOUN
dpc-2859	27	18	with	with	ADP
dpc-2859	27	19	the	the	DET
dpc-2859	27	20	natural	natural	ADJ
dpc-2859	27	21	immune	immune	ADJ
dpc-2859	27	22	activation	activation	NOUN
dpc-2859	27	23	of	of	ADP
dpc-2859	27	24	propionibacterium	propionibacterium	NOUN
dpc-2859	27	25	acnes	acne	NOUN
dpc-2859	27	26	and	and	CCONJ
dpc-2859	27	27	increased	increase	VERB
dpc-2859	27	28	inflammation	inflammation	NOUN
dpc-2859	27	29	.	.	PUNCT
dpc-2859	28	1	lesions	lesion	NOUN
dpc-2859	28	2	of	of	ADP
dpc-2859	28	3	various	various	ADJ
dpc-2859	28	4	variations	variation	NOUN
dpc-2859	28	5	such	such	ADJ
dpc-2859	28	6	as	as	ADP
dpc-2859	28	7	come	come	VERB
dpc-2859	28	8	done	do	VERB
dpc-2859	28	9	,	,	PUNCT
dpc-2859	28	10	papule	papule	NOUN
dpc-2859	28	11	,	,	PUNCT
dpc-2859	28	12	pustule	pustule	NOUN
dpc-2859	28	13	,	,	PUNCT
dpc-2859	28	14	nodule	nodule	NOUN
dpc-2859	28	15	and	and	CCONJ
dpc-2859	28	16	rarely	rarely	ADV
dpc-2859	28	17	cyst	cyst	VERB
dpc-2859	28	18	,	,	PUNCT
dpc-2859	28	19	characterize	characterize	VERB
dpc-2859	28	20	acne	acne	NOUN
dpc-2859	28	21	[	[	X
dpc-2859	28	22	4	4	NUM
dpc-2859	28	23	]	]	PUNCT
dpc-2859	28	24	.	.	PUNCT
dpc-2859	29	1	the	the	DET
dpc-2859	29	2	distribution	distribution	NOUN
dpc-2859	29	3	of	of	ADP
dpc-2859	29	4	acne	acne	NOUN
dpc-2859	29	5	lesions	lesion	NOUN
dpc-2859	29	6	is	be	AUX
dpc-2859	29	7	often	often	ADV
dpc-2859	29	8	the	the	DET
dpc-2859	29	9	face	face	NOUN
dpc-2859	29	10	,	,	PUNCT
dpc-2859	29	11	back	back	ADV
dpc-2859	29	12	,	,	PUNCT
dpc-2859	29	13	chest	chest	NOUN
dpc-2859	29	14	and	and	CCONJ
dpc-2859	29	15	shoulder	shoulder	NOUN
dpc-2859	29	16	areas	area	NOUN
dpc-2859	29	17	where	where	SCONJ
dpc-2859	29	18	sebaceous	sebaceous	ADJ
dpc-2859	29	19	glands	gland	NOUN
dpc-2859	29	20	are	be	AUX
dpc-2859	29	21	densely	densely	ADV
dpc-2859	29	22	located	locate	VERB
dpc-2859	29	23	.	.	PUNCT
dpc-2859	30	1	treatment	treatment	NOUN
dpc-2859	30	2	of	of	ADP
dpc-2859	30	3	acne	acne	NOUN
dpc-2859	30	4	vulgaris	vulgaris	NOUN
dpc-2859	30	5	varies	vary	VERB
dpc-2859	30	6	based	base	VERB
dpc-2859	30	7	on	on	ADP
dpc-2859	30	8	the	the	DET
dpc-2859	30	9	type	type	NOUN
dpc-2859	30	10	,	,	PUNCT
dpc-2859	30	11	extent	extent	NOUN
dpc-2859	30	12	and	and	CCONJ
dpc-2859	30	13	severity	severity	NOUN
dpc-2859	30	14	of	of	ADP
dpc-2859	30	15	the	the	DET
dpc-2859	30	16	lesions	lesion	NOUN
dpc-2859	30	17	.	.	PUNCT
dpc-2859	31	1	while	while	SCONJ
dpc-2859	31	2	topical	topical	ADJ
dpc-2859	31	3	antibiotics	antibiotic	NOUN
dpc-2859	31	4	and	and	CCONJ
dpc-2859	31	5	retinoid	retinoid	NOUN
dpc-2859	31	6	are	be	AUX
dpc-2859	31	7	the	the	DET
dpc-2859	31	8	first	first	ADJ
dpc-2859	31	9	choice	choice	NOUN
dpc-2859	31	10	in	in	ADP
dpc-2859	31	11	the	the	DET
dpc-2859	31	12	treatment	treatment	NOUN
dpc-2859	31	13	of	of	ADP
dpc-2859	31	14	mild	mild	ADJ
dpc-2859	31	15	acne	acne	NOUN
dpc-2859	31	16	,	,	PUNCT
dpc-2859	31	17	systemic	systemic	ADJ
dpc-2859	31	18	antibiotics	antibiotic	NOUN
dpc-2859	31	19	and	and	CCONJ
dpc-2859	31	20	anti	anti	ADJ
dpc-2859	31	21	-	-	ADJ
dpc-2859	31	22	androgenic	androgenic	ADJ
dpc-2859	31	23	agents	agent	NOUN
dpc-2859	31	24	are	be	AUX
dpc-2859	31	25	used	use	VERB
dpc-2859	31	26	in	in	ADP
dpc-2859	31	27	moderate	moderate	ADJ
dpc-2859	31	28	to	to	ADP
dpc-2859	31	29	severe	severe	ADJ
dpc-2859	31	30	acne	acne	NOUN
dpc-2859	31	31	[	[	X
dpc-2859	31	32	5,6	5,6	NUM
dpc-2859	31	33	]	]	X
dpc-2859	31	34	.	.	PUNCT
dpc-2859	32	1	the	the	DET
dpc-2859	32	2	most	most	ADV
dpc-2859	32	3	effective	effective	ADJ
dpc-2859	32	4	treatment	treatment	NOUN
dpc-2859	32	5	method	method	NOUN
dpc-2859	32	6	for	for	ADP
dpc-2859	32	7	severe	severe	ADJ
dpc-2859	32	8	acne	acne	NOUN
dpc-2859	32	9	is	be	AUX
dpc-2859	32	10	systemic	systemic	ADJ
dpc-2859	32	11	isotretinoin	isotretinoin	PROPN
dpc-2859	32	12	.	.	PUNCT
dpc-2859	33	1	isotretinoin	isotretinoin	PROPN
dpc-2859	33	2	is	be	AUX
dpc-2859	33	3	an	an	DET
dpc-2859	33	4	agent	agent	NOUN
dpc-2859	33	5	that	that	PRON
dpc-2859	33	6	suppresses	suppress	VERB
dpc-2859	33	7	sebum	sebum	NOUN
dpc-2859	33	8	production	production	NOUN
dpc-2859	33	9	and	and	CCONJ
dpc-2859	33	10	is	be	AUX
dpc-2859	33	11	effective	effective	ADJ
dpc-2859	33	12	on	on	ADP
dpc-2859	33	13	all	all	DET
dpc-2859	33	14	pathogenic	pathogenic	ADJ
dpc-2859	33	15	factors	factor	NOUN
dpc-2859	33	16	that	that	PRON
dpc-2859	33	17	play	play	VERB
dpc-2859	33	18	a	a	DET
dpc-2859	33	19	role	role	NOUN
dpc-2859	33	20	in	in	ADP
dpc-2859	33	21	the	the	DET
dpc-2859	33	22	formation	formation	NOUN
dpc-2859	33	23	of	of	ADP
dpc-2859	33	24	acne	acne	NOUN
dpc-2859	33	25	and	and	CCONJ
dpc-2859	33	26	has	have	AUX
dpc-2859	33	27	been	be	AUX
dpc-2859	33	28	used	use	VERB
dpc-2859	33	29	in	in	ADP
dpc-2859	33	30	the	the	DET
dpc-2859	33	31	usa	usa	PROPN
dpc-2859	33	32	since	since	SCONJ
dpc-2859	33	33	1982	1982	NUM
dpc-2859	33	34	in	in	ADP
dpc-2859	33	35	the	the	DET
dpc-2859	33	36	treatment	treatment	NOUN
dpc-2859	33	37	of	of	ADP
dpc-2859	33	38	severe	severe	ADJ
dpc-2859	33	39	nodulocystic	nodulocystic	ADJ
dpc-2859	33	40	and	and	CCONJ
dpc-2859	33	41	persistent	persistent	ADJ
dpc-2859	33	42	acne	acne	NOUN
dpc-2859	33	43	.	.	PUNCT
dpc-2859	34	1	however	however	ADV
dpc-2859	34	2	,	,	PUNCT
dpc-2859	34	3	as	as	SCONJ
dpc-2859	34	4	antibiotic	antibiotic	ADJ
dpc-2859	34	5	resistance	resistance	NOUN
dpc-2859	34	6	is	be	AUX
dpc-2859	34	7	increasing	increase	VERB
dpc-2859	34	8	worldwide	worldwide	ADV
dpc-2859	34	9	,	,	PUNCT
dpc-2859	34	10	antibiotic	antibiotic	ADJ
dpc-2859	34	11	monotherapy	monotherapy	NOUN
dpc-2859	34	12	has	have	AUX
dpc-2859	34	13	begun	begin	VERB
dpc-2859	34	14	to	to	PART
dpc-2859	34	15	be	be	AUX
dpc-2859	34	16	used	use	VERB
dpc-2859	34	17	less	less	ADV
dpc-2859	34	18	frequently	frequently	ADV
dpc-2859	34	19	in	in	ADP
dpc-2859	34	20	acne	acne	NOUN
dpc-2859	34	21	treatment	treatment	NOUN
dpc-2859	34	22	.	.	PUNCT
dpc-2859	35	1	classically	classically	ADV
dpc-2859	35	2	used	use	VERB
dpc-2859	35	3	for	for	ADP
dpc-2859	35	4	nodulocystic	nodulocystic	ADJ
dpc-2859	35	5	acne	acne	NOUN
dpc-2859	35	6	,	,	PUNCT
dpc-2859	35	7	isotretinoin	isotretinoin	PROPN
dpc-2859	35	8	has	have	AUX
dpc-2859	35	9	become	become	VERB
dpc-2859	35	10	the	the	DET
dpc-2859	35	11	drug	drug	NOUN
dpc-2859	35	12	of	of	ADP
dpc-2859	35	13	choice	choice	NOUN
dpc-2859	35	14	by	by	ADP
dpc-2859	35	15	dermatologists	dermatologist	NOUN
dpc-2859	35	16	for	for	ADP
dpc-2859	35	17	moderate	moderate	ADJ
dpc-2859	35	18	acne	acne	NOUN
dpc-2859	35	19	.	.	PUNCT
dpc-2859	36	1	it	it	PRON
dpc-2859	36	2	can	can	AUX
dpc-2859	36	3	also	also	ADV
dpc-2859	36	4	be	be	AUX
dpc-2859	36	5	used	use	VERB
dpc-2859	36	6	in	in	ADP
dpc-2859	36	7	seborrheic	seborrheic	PROPN
dpc-2859	36	8	dermatitis	dermatitis	NOUN
dpc-2859	36	9	,	,	PUNCT
dpc-2859	36	10	acne	acne	NOUN
dpc-2859	36	11	rosacea	rosacea	NOUN
dpc-2859	36	12	,	,	PUNCT
dpc-2859	36	13	and	and	CCONJ
dpc-2859	36	14	perioral	perioral	ADJ
dpc-2859	36	15	dermatitis	dermatitis	NOUN
dpc-2859	36	16	resistant	resistant	ADJ
dpc-2859	36	17	to	to	ADP
dpc-2859	36	18	classical	classical	ADJ
dpc-2859	36	19	treatment	treatment	NOUN
dpc-2859	36	20	[	[	X
dpc-2859	36	21	7	7	NUM
dpc-2859	36	22	-	-	SYM
dpc-2859	36	23	9	9	NUM
dpc-2859	36	24	]	]	PUNCT
dpc-2859	36	25	.	.	PUNCT
dpc-2859	37	1	treatment	treatment	NOUN
dpc-2859	37	2	protocol	protocol	NOUN
dpc-2859	37	3	recommended	recommend	VERB
dpc-2859	37	4	in	in	ADP
dpc-2859	37	5	clinical	clinical	ADJ
dpc-2859	37	6	applications	application	NOUN
dpc-2859	37	7	is	be	AUX
dpc-2859	37	8	the	the	DET
dpc-2859	37	9	use	use	NOUN
dpc-2859	37	10	of	of	ADP
dpc-2859	37	11	0.5	0.5	NUM
dpc-2859	37	12	-	-	SYM
dpc-2859	37	13	1	1	NUM
dpc-2859	37	14	mg	mg	PROPN
dpc-2859	37	15	/	/	SYM
dpc-2859	37	16	kg	kg	NOUN
dpc-2859	37	17	/	/	SYM
dpc-2859	37	18	day	day	NOUN
dpc-2859	37	19	over	over	ADP
dpc-2859	37	20	a	a	DET
dpc-2859	37	21	period	period	NOUN
dpc-2859	37	22	of	of	ADP
dpc-2859	37	23	4	4	NUM
dpc-2859	37	24	-	-	SYM
dpc-2859	37	25	12	12	NUM
dpc-2859	37	26	months	month	NOUN
dpc-2859	37	27	to	to	PART
dpc-2859	37	28	reach	reach	VERB
dpc-2859	37	29	a	a	DET
dpc-2859	37	30	total	total	ADJ
dpc-2859	37	31	dose	dose	NOUN
dpc-2859	37	32	of	of	ADP
dpc-2859	37	33	120	120	NUM
dpc-2859	37	34	-	-	SYM
dpc-2859	37	35	150	150	NUM
dpc-2859	37	36	mg	mg	NUM
dpc-2859	37	37	/	/	SYM
dpc-2859	37	38	kg	kg	NOUN
dpc-2859	38	1	[	[	X
dpc-2859	38	2	10	10	NUM
dpc-2859	38	3	]	]	PUNCT
dpc-2859	38	4	.	.	PUNCT
dpc-2859	39	1	the	the	DET
dpc-2859	39	2	most	most	ADV
dpc-2859	39	3	common	common	ADJ
dpc-2859	39	4	side	side	NOUN
dpc-2859	39	5	effects	effect	NOUN
dpc-2859	39	6	observed	observe	VERB
dpc-2859	39	7	during	during	ADP
dpc-2859	39	8	isotretinoin	isotretinoin	PROPN
dpc-2859	39	9	use	use	NOUN
dpc-2859	39	10	are	be	AUX
dpc-2859	39	11	mucocutaneous	mucocutaneous	ADJ
dpc-2859	39	12	side	side	NOUN
dpc-2859	39	13	effects	effect	NOUN
dpc-2859	39	14	.	.	PUNCT
dpc-2859	40	1	mucocutaneous	mucocutaneous	ADJ
dpc-2859	40	2	side	side	NOUN
dpc-2859	40	3	effects	effect	NOUN
dpc-2859	40	4	develop	develop	VERB
dpc-2859	40	5	secondary	secondary	ADJ
dpc-2859	40	6	to	to	ADP
dpc-2859	40	7	a	a	DET
dpc-2859	40	8	decrease	decrease	NOUN
dpc-2859	40	9	in	in	ADP
dpc-2859	40	10	sebum	sebum	NOUN
dpc-2859	40	11	production	production	NOUN
dpc-2859	40	12	,	,	PUNCT
dpc-2859	40	13	thinning	thinning	NOUN
dpc-2859	40	14	of	of	ADP
dpc-2859	40	15	the	the	DET
dpc-2859	40	16	stratum	stratum	NOUN
dpc-2859	40	17	corneum	corneum	NOUN
dpc-2859	40	18	and	and	CCONJ
dpc-2859	40	19	changes	change	NOUN
dpc-2859	40	20	in	in	ADP
dpc-2859	40	21	skin	skin	NOUN
dpc-2859	40	22	barrier	barrier	NOUN
dpc-2859	40	23	functions	function	NOUN
dpc-2859	40	24	,	,	PUNCT
dpc-2859	40	25	among	among	ADP
dpc-2859	40	26	which	which	PRON
dpc-2859	40	27	the	the	DET
dpc-2859	40	28	most	most	ADV
dpc-2859	40	29	common	common	ADJ
dpc-2859	40	30	side	side	NOUN
dpc-2859	40	31	effect	effect	NOUN
dpc-2859	40	32	observed	observe	VERB
dpc-2859	40	33	is	be	AUX
dpc-2859	40	34	cheilitis	cheilitis	NOUN
dpc-2859	40	35	.	.	PUNCT
dpc-2859	41	1	almost	almost	ADV
dpc-2859	41	2	all	all	DET
dpc-2859	41	3	patients	patient	NOUN
dpc-2859	41	4	have	have	VERB
dpc-2859	41	5	cheilitis	cheilitis	NOUN
dpc-2859	41	6	with	with	ADP
dpc-2859	41	7	varying	vary	VERB
dpc-2859	41	8	severity	severity	NOUN
dpc-2859	41	9	.	.	PUNCT
dpc-2859	42	1	other	other	ADJ
dpc-2859	42	2	common	common	ADJ
dpc-2859	42	3	side	side	NOUN
dpc-2859	42	4	effects	effect	NOUN
dpc-2859	42	5	of	of	ADP
dpc-2859	42	6	systemic	systemic	ADJ
dpc-2859	42	7	isotretinoin	isotretinoin	PROPN
dpc-2859	42	8	are	be	AUX
dpc-2859	42	9	nosebleeds	nosebleed	NOUN
dpc-2859	42	10	,	,	PUNCT
dpc-2859	42	11	generalized	generalized	ADJ
dpc-2859	42	12	muscle	muscle	NOUN
dpc-2859	42	13	aches	ache	NOUN
dpc-2859	42	14	,	,	PUNCT
dpc-2859	42	15	malaise	malaise	NOUN
dpc-2859	42	16	,	,	PUNCT
dpc-2859	42	17	and	and	CCONJ
dpc-2859	42	18	dry	dry	ADJ
dpc-2859	42	19	eyes	eye	NOUN
dpc-2859	42	20	.	.	PUNCT
dpc-2859	43	1	the	the	DET
dpc-2859	43	2	most	most	ADV
dpc-2859	43	3	important	important	ADJ
dpc-2859	43	4	side	side	NOUN
dpc-2859	43	5	effect	effect	NOUN
dpc-2859	43	6	of	of	ADP
dpc-2859	43	7	the	the	DET
dpc-2859	43	8	drug	drug	NOUN
dpc-2859	43	9	is	be	AUX
dpc-2859	43	10	its	its	PRON
dpc-2859	43	11	teratogenic	teratogenic	ADJ
dpc-2859	43	12	effect	effect	NOUN
dpc-2859	43	13	[	[	X
dpc-2859	43	14	11,12	11,12	NUM
dpc-2859	43	15	]	]	PUNCT
dpc-2859	43	16	.	.	PUNCT
dpc-2859	44	1	another	another	DET
dpc-2859	44	2	system	system	NOUN
dpc-2859	44	3	in	in	ADP
dpc-2859	44	4	which	which	PRON
dpc-2859	44	5	side	side	NOUN
dpc-2859	44	6	effects	effect	NOUN
dpc-2859	44	7	of	of	ADP
dpc-2859	44	8	isotretinoin	isotretinoin	PROPN
dpc-2859	44	9	are	be	AUX
dpc-2859	44	10	seen	see	VERB
dpc-2859	44	11	is	be	AUX
dpc-2859	44	12	the	the	DET
dpc-2859	44	13	gastrointestinal	gastrointestinal	ADJ
dpc-2859	44	14	system	system	NOUN
dpc-2859	44	15	(	(	PUNCT
dpc-2859	44	16	gis	gis	NOUN
dpc-2859	44	17	)	)	PUNCT
dpc-2859	44	18	.	.	PUNCT
dpc-2859	45	1	regarding	regard	VERB
dpc-2859	45	2	the	the	DET
dpc-2859	45	3	side	side	NOUN
dpc-2859	45	4	effects	effect	NOUN
dpc-2859	45	5	of	of	ADP
dpc-2859	45	6	gis	gis	PROPN
dpc-2859	45	7	,	,	PUNCT
dpc-2859	45	8	martin	martin	PROPN
dpc-2859	45	9	et	et	PROPN
dpc-2859	45	10	al	al	PROPN
dpc-2859	45	11	.	.	PROPN
dpc-2859	45	12	have	have	AUX
dpc-2859	45	13	been	be	AUX
dpc-2859	45	14	the	the	DET
dpc-2859	45	15	first	first	ADJ
dpc-2859	45	16	to	to	PART
dpc-2859	45	17	report	report	VERB
dpc-2859	45	18	a	a	DET
dpc-2859	45	19	case	case	NOUN
dpc-2859	45	20	of	of	ADP
dpc-2859	45	21	proctosigmoiditis	proctosigmoiditis	ADJ
dpc-2859	45	22	in	in	ADP
dpc-2859	45	23	1987	1987	NUM
dpc-2859	45	24	.	.	PUNCT
dpc-2859	46	1	afterwards	afterwards	ADV
dpc-2859	46	2	,	,	PUNCT
dpc-2859	46	3	a	a	DET
dpc-2859	46	4	few	few	ADJ
dpc-2859	46	5	more	more	ADJ
dpc-2859	46	6	cases	case	NOUN
dpc-2859	46	7	have	have	AUX
dpc-2859	46	8	been	be	AUX
dpc-2859	46	9	reported	report	VERB
dpc-2859	46	10	on	on	ADP
dpc-2859	46	11	isotretinoin	isotretinoin	PROPN
dpc-2859	46	12	-	-	PUNCT
dpc-2859	46	13	related	relate	VERB
dpc-2859	46	14	inflammatory	inflammatory	ADJ
dpc-2859	46	15	bowel	bowel	NOUN
dpc-2859	46	16	disease	disease	NOUN
dpc-2859	46	17	(	(	PUNCT
dpc-2859	46	18	ibd	ibd	NOUN
dpc-2859	46	19	)	)	PUNCT
dpc-2859	47	1	[	[	X
dpc-2859	47	2	13,14	13,14	NUM
dpc-2859	47	3	]	]	PUNCT
dpc-2859	47	4	.	.	PUNCT
dpc-2859	48	1	objectives	objective	NOUN
dpc-2859	48	2	isotretinoin	isotretinoin	PROPN
dpc-2859	48	3	can	can	AUX
dpc-2859	48	4	also	also	ADV
dpc-2859	48	5	dry	dry	VERB
dpc-2859	48	6	the	the	DET
dpc-2859	48	7	anal	anal	ADJ
dpc-2859	48	8	mucosa	mucosa	NOUN
dpc-2859	48	9	,	,	PUNCT
dpc-2859	48	10	triggering	trigger	VERB
dpc-2859	48	11	fissure	fissure	NOUN
dpc-2859	48	12	formation	formation	NOUN
dpc-2859	48	13	.	.	PUNCT
dpc-2859	49	1	in	in	ADP
dpc-2859	49	2	this	this	DET
dpc-2859	49	3	study	study	NOUN
dpc-2859	49	4	,	,	PUNCT
dpc-2859	49	5	we	we	PRON
dpc-2859	49	6	evaluated	evaluate	VERB
dpc-2859	49	7	the	the	DET
dpc-2859	49	8	side	side	NOUN
dpc-2859	49	9	effects	effect	NOUN
dpc-2859	49	10	and	and	CCONJ
dpc-2859	49	11	especially	especially	ADV
dpc-2859	49	12	the	the	DET
dpc-2859	49	13	development	development	NOUN
dpc-2859	49	14	of	of	ADP
dpc-2859	49	15	anal	anal	ADJ
dpc-2859	49	16	fissures	fissure	NOUN
dpc-2859	49	17	,	,	PUNCT
dpc-2859	49	18	mucosal	mucosal	NOUN
dpc-2859	49	19	damage	damage	NOUN
dpc-2859	49	20	and	and	CCONJ
dpc-2859	49	21	rectal	rectal	ADJ
dpc-2859	49	22	bleeding	bleeding	NOUN
dpc-2859	49	23	in	in	ADP
dpc-2859	49	24	patients	patient	NOUN
dpc-2859	49	25	receiving	receive	VERB
dpc-2859	49	26	systemic	systemic	ADJ
dpc-2859	49	27	isotretinoin	isotretinoin	PROPN
dpc-2859	49	28	therapy	therapy	NOUN
dpc-2859	49	29	.	.	PUNCT
dpc-2859	50	1	methods	method	NOUN
dpc-2859	50	2	the	the	DET
dpc-2859	50	3	study	study	NOUN
dpc-2859	50	4	included	include	VERB
dpc-2859	50	5	all	all	DET
dpc-2859	50	6	patients	patient	NOUN
dpc-2859	50	7	who	who	PRON
dpc-2859	50	8	applied	apply	VERB
dpc-2859	50	9	to	to	ADP
dpc-2859	50	10	dermatology	dermatology	NOUN
dpc-2859	50	11	clinic	clinic	NOUN
dpc-2859	50	12	between	between	ADP
dpc-2859	50	13	2018	2018	NUM
dpc-2859	50	14	-	-	SYM
dpc-2859	50	15	2019	2019	NUM
dpc-2859	50	16	and	and	CCONJ
dpc-2859	50	17	received	receive	VERB
dpc-2859	50	18	systemic	systemic	ADJ
dpc-2859	50	19	isotretinoin	isotretinoin	PROPN
dpc-2859	50	20	therapy	therapy	NOUN
dpc-2859	50	21	.	.	PUNCT
dpc-2859	51	1	the	the	DET
dpc-2859	51	2	data	datum	NOUN
dpc-2859	51	3	were	be	AUX
dpc-2859	51	4	evaluated	evaluate	VERB
dpc-2859	51	5	retrospectively	retrospectively	ADV
dpc-2859	51	6	(	(	PUNCT
dpc-2859	51	7	the	the	DET
dpc-2859	51	8	local	local	ADJ
dpc-2859	51	9	ethics	ethic	NOUN
dpc-2859	51	10	committee	committee	PROPN
dpc-2859	51	11	confirmed	confirm	VERB
dpc-2859	51	12	that	that	SCONJ
dpc-2859	51	13	formal	formal	ADJ
dpc-2859	51	14	approval	approval	NOUN
dpc-2859	51	15	was	be	AUX
dpc-2859	51	16	not	not	PART
dpc-2859	51	17	required	require	VERB
dpc-2859	51	18	for	for	ADP
dpc-2859	51	19	this	this	DET
dpc-2859	51	20	retrospective	retrospective	ADJ
dpc-2859	51	21	audit	audit	NOUN
dpc-2859	51	22	of	of	ADP
dpc-2859	51	23	practice	practice	NOUN
dpc-2859	51	24	)	)	PUNCT
dpc-2859	51	25	.	.	PUNCT
dpc-2859	52	1	patients	patient	NOUN
dpc-2859	52	2	with	with	ADP
dpc-2859	52	3	missing	miss	VERB
dpc-2859	52	4	data	datum	NOUN
dpc-2859	52	5	were	be	AUX
dpc-2859	52	6	excluded	exclude	VERB
dpc-2859	52	7	from	from	ADP
dpc-2859	52	8	the	the	DET
dpc-2859	52	9	study	study	NOUN
dpc-2859	52	10	.	.	PUNCT
dpc-2859	53	1	participants	participant	NOUN
dpc-2859	53	2	were	be	AUX
dpc-2859	53	3	informed	inform	VERB
dpc-2859	53	4	about	about	ADP
dpc-2859	53	5	the	the	DET
dpc-2859	53	6	study	study	NOUN
dpc-2859	53	7	.	.	PUNCT
dpc-2859	54	1	adolescents	adolescent	NOUN
dpc-2859	54	2	who	who	PRON
dpc-2859	54	3	agreed	agree	VERB
dpc-2859	54	4	to	to	PART
dpc-2859	54	5	participate	participate	VERB
dpc-2859	54	6	in	in	ADP
dpc-2859	54	7	the	the	DET
dpc-2859	54	8	study	study	NOUN
dpc-2859	54	9	provided	provide	VERB
dpc-2859	54	10	signed	sign	VERB
dpc-2859	54	11	informed	informed	ADJ
dpc-2859	54	12	consent	consent	NOUN
dpc-2859	54	13	forms	form	NOUN
dpc-2859	54	14	.	.	PUNCT
dpc-2859	55	1	before	before	ADP
dpc-2859	55	2	treatment	treatment	NOUN
dpc-2859	55	3	,	,	PUNCT
dpc-2859	55	4	all	all	DET
dpc-2859	55	5	patients	patient	NOUN
dpc-2859	55	6	and	and	CCONJ
dpc-2859	55	7	their	their	PRON
dpc-2859	55	8	families	family	NOUN
dpc-2859	55	9	were	be	AUX
dpc-2859	55	10	questioned	question	VERB
dpc-2859	55	11	for	for	ADP
dpc-2859	55	12	hyperlipidemia	hyperlipidemia	NOUN
dpc-2859	55	13	and	and	CCONJ
dpc-2859	55	14	atherosclerosis	atherosclerosis	NOUN
dpc-2859	55	15	.	.	PUNCT
dpc-2859	56	1	patients	patient	NOUN
dpc-2859	56	2	’	'	PUNCT
dpc-2859	56	3	demographic	demographic	ADJ
dpc-2859	56	4	data	datum	NOUN
dpc-2859	56	5	such	such	ADJ
dpc-2859	56	6	as	as	ADP
dpc-2859	56	7	age	age	NOUN
dpc-2859	56	8	and	and	CCONJ
dpc-2859	56	9	gender	gender	NOUN
dpc-2859	56	10	as	as	ADV
dpc-2859	56	11	well	well	ADV
dpc-2859	56	12	as	as	ADP
dpc-2859	56	13	body	body	NOUN
dpc-2859	56	14	weight	weight	NOUN
dpc-2859	56	15	,	,	PUNCT
dpc-2859	56	16	duration	duration	NOUN
dpc-2859	56	17	of	of	ADP
dpc-2859	56	18	the	the	DET
dpc-2859	56	19	disease	disease	NOUN
dpc-2859	56	20	and	and	CCONJ
dpc-2859	56	21	the	the	DET
dpc-2859	56	22	medications	medication	NOUN
dpc-2859	56	23	used	use	VERB
dpc-2859	56	24	were	be	AUX
dpc-2859	56	25	recorded	record	VERB
dpc-2859	56	26	.	.	PUNCT
dpc-2859	57	1	before	before	ADP
dpc-2859	57	2	treatment	treatment	NOUN
dpc-2859	57	3	,	,	PUNCT
dpc-2859	57	4	after	after	ADP
dpc-2859	57	5	treatment	treatment	NOUN
dpc-2859	57	6	and	and	CCONJ
dpc-2859	57	7	at	at	ADP
dpc-2859	57	8	intervals	interval	NOUN
dpc-2859	57	9	during	during	ADP
dpc-2859	57	10	treatment	treatment	NOUN
dpc-2859	57	11	,	,	PUNCT
dpc-2859	57	12	the	the	DET
dpc-2859	57	13	following	follow	VERB
dpc-2859	57	14	laboratory	laboratory	NOUN
dpc-2859	57	15	values	value	NOUN
dpc-2859	57	16	were	be	AUX
dpc-2859	57	17	examined	examine	VERB
dpc-2859	57	18	:	:	PUNCT
dpc-2859	57	19	hemoglobin	hemoglobin	NOUN
dpc-2859	57	20	,	,	PUNCT
dpc-2859	57	21	hematocrit	hematocrit	ADJ
dpc-2859	57	22	,	,	PUNCT
dpc-2859	57	23	leukocyte	leukocyte	NOUN
dpc-2859	57	24	,	,	PUNCT
dpc-2859	57	25	platelet	platelet	NOUN
dpc-2859	57	26	count	count	NOUN
dpc-2859	57	27	,	,	PUNCT
dpc-2859	57	28	erythrocyte	erythrocyte	PROPN
dpc-2859	57	29	sedimentation	sedimentation	NOUN
dpc-2859	57	30	rate	rate	NOUN
dpc-2859	57	31	(	(	PUNCT
dpc-2859	57	32	esr	esr	PROPN
dpc-2859	57	33	)	)	PUNCT
dpc-2859	57	34	,	,	PUNCT
dpc-2859	57	35	alkaline	alkaline	ADJ
dpc-2859	57	36	phosphatase	phosphatase	NOUN
dpc-2859	57	37	(	(	PUNCT
dpc-2859	57	38	alp	alp	PROPN
dpc-2859	57	39	)	)	PUNCT
dpc-2859	57	40	,	,	PUNCT
dpc-2859	57	41	lactate	lactate	NOUN
dpc-2859	57	42	dehydrogenase	dehydrogenase	NOUN
dpc-2859	57	43	(	(	PUNCT
dpc-2859	57	44	ldh	ldh	NOUN
dpc-2859	57	45	)	)	PUNCT
dpc-2859	57	46	,	,	PUNCT
dpc-2859	57	47	aspartate	aspartate	NOUN
dpc-2859	57	48	aminotransferase	aminotransferase	NOUN
dpc-2859	57	49	(	(	PUNCT
dpc-2859	57	50	ast	ast	PROPN
dpc-2859	57	51	)	)	PUNCT
dpc-2859	57	52	,	,	PUNCT
dpc-2859	57	53	alanine	alanine	NOUN
dpc-2859	57	54	aminotransferase	aminotransferase	PROPN
dpc-2859	57	55	(	(	PUNCT
dpc-2859	57	56	alt	alt	PROPN
dpc-2859	57	57	)	)	PUNCT
dpc-2859	57	58	,	,	PUNCT
dpc-2859	57	59	cholesterol	cholesterol	NOUN
dpc-2859	57	60	(	(	PUNCT
dpc-2859	57	61	low	low	ADJ
dpc-2859	57	62	density	density	NOUN
dpc-2859	57	63	cholesterol	cholesterol	NOUN
dpc-2859	57	64	(	(	PUNCT
dpc-2859	57	65	ldl	ldl	NOUN
dpc-2859	57	66	)	)	PUNCT
dpc-2859	57	67	high	high	ADJ
dpc-2859	57	68	density	density	NOUN
dpc-2859	57	69	cholesterol	cholesterol	NOUN
dpc-2859	57	70	(	(	PUNCT
dpc-2859	57	71	hdl	hdl	PROPN
dpc-2859	57	72	)	)	PUNCT
dpc-2859	57	73	,	,	PUNCT
dpc-2859	57	74	very	very	ADV
dpc-2859	57	75	low	low	ADJ
dpc-2859	57	76	density	density	NOUN
dpc-2859	57	77	cholesterol	cholesterol	NOUN
dpc-2859	57	78	(	(	PUNCT
dpc-2859	57	79	vldl	vldl	PROPN
dpc-2859	57	80	)	)	PUNCT
dpc-2859	57	81	,	,	PUNCT
dpc-2859	57	82	triglyceride	triglyceride	ADV
dpc-2859	57	83	,	,	PUNCT
dpc-2859	57	84	creatine	creatine	PROPN
dpc-2859	57	85	kinase	kinase	PROPN
dpc-2859	57	86	(	(	PUNCT
dpc-2859	57	87	ck	ck	PROPN
dpc-2859	57	88	)	)	PUNCT
dpc-2859	57	89	,	,	PUNCT
dpc-2859	57	90	and	and	CCONJ
dpc-2859	57	91	monthly	monthly	ADJ
dpc-2859	57	92	beta	beta	NOUN
dpc-2859	57	93	-	-	PUNCT
dpc-2859	57	94	human	human	ADJ
dpc-2859	57	95	chorionic	chorionic	ADJ
dpc-2859	57	96	gonadotropin	gonadotropin	NOUN
dpc-2859	57	97	(	(	PUNCT
dpc-2859	57	98	b	b	X
dpc-2859	57	99	-	-	PUNCT
dpc-2859	57	100	hcg	hcg	NOUN
dpc-2859	57	101	)	)	PUNCT
dpc-2859	57	102	in	in	ADP
dpc-2859	57	103	female	female	ADJ
dpc-2859	57	104	patients	patient	NOUN
dpc-2859	57	105	.	.	PUNCT
dpc-2859	58	1	in	in	ADP
dpc-2859	58	2	the	the	DET
dpc-2859	58	3	monthly	monthly	ADJ
dpc-2859	58	4	follow	follow	NOUN
dpc-2859	58	5	-	-	PUNCT
dpc-2859	58	6	ups	up	NOUN
dpc-2859	58	7	,	,	PUNCT
dpc-2859	58	8	all	all	DET
dpc-2859	58	9	side	side	NOUN
dpc-2859	58	10	effects	effect	NOUN
dpc-2859	58	11	were	be	AUX
dpc-2859	58	12	questioned	question	VERB
dpc-2859	58	13	in	in	ADP
dpc-2859	58	14	detail	detail	NOUN
dpc-2859	58	15	.	.	PUNCT
dpc-2859	59	1	especially	especially	ADV
dpc-2859	59	2	,	,	PUNCT
dpc-2859	59	3	patients	patient	NOUN
dpc-2859	59	4	with	with	ADP
dpc-2859	59	5	gastrointestinal	gastrointestinal	ADJ
dpc-2859	59	6	system	system	NOUN
dpc-2859	59	7	complaints	complaint	NOUN
dpc-2859	59	8	were	be	AUX
dpc-2859	59	9	referred	refer	VERB
dpc-2859	59	10	to	to	ADP
dpc-2859	59	11	the	the	DET
dpc-2859	59	12	general	general	ADJ
dpc-2859	59	13	surgery	surgery	NOUN
dpc-2859	59	14	clinic	clinic	NOUN
dpc-2859	59	15	.	.	PUNCT
dpc-2859	60	1	the	the	DET
dpc-2859	60	2	data	datum	NOUN
dpc-2859	60	3	of	of	ADP
dpc-2859	60	4	the	the	DET
dpc-2859	60	5	patients	patient	NOUN
dpc-2859	60	6	,	,	PUNCT
dpc-2859	60	7	whose	whose	DET
dpc-2859	60	8	detailed	detailed	ADJ
dpc-2859	60	9	examinations	examination	NOUN
dpc-2859	60	10	were	be	AUX
dpc-2859	60	11	performed	perform	VERB
dpc-2859	60	12	here	here	ADV
dpc-2859	60	13	,	,	PUNCT
dpc-2859	60	14	were	be	AUX
dpc-2859	60	15	recorded	record	VERB
dpc-2859	60	16	on	on	ADP
dpc-2859	60	17	the	the	DET
dpc-2859	60	18	follow	follow	VERB
dpc-2859	60	19	-	-	PUNCT
dpc-2859	60	20	up	up	ADP
dpc-2859	60	21	form	form	NOUN
dpc-2859	60	22	.	.	PUNCT
dpc-2859	61	1	the	the	DET
dpc-2859	61	2	treatment	treatment	NOUN
dpc-2859	61	3	of	of	ADP
dpc-2859	61	4	patients	patient	NOUN
dpc-2859	61	5	who	who	PRON
dpc-2859	61	6	could	could	AUX
dpc-2859	61	7	not	not	PART
dpc-2859	61	8	tolerate	tolerate	VERB
dpc-2859	61	9	side	side	NOUN
dpc-2859	61	10	effects	effect	NOUN
dpc-2859	61	11	and	and	CCONJ
dpc-2859	61	12	had	have	VERB
dpc-2859	61	13	abnormal	abnormal	ADJ
dpc-2859	61	14	laboratory	laboratory	NOUN
dpc-2859	61	15	findings	finding	NOUN
dpc-2859	61	16	was	be	AUX
dpc-2859	61	17	terminated	terminate	VERB
dpc-2859	61	18	.	.	PUNCT
dpc-2859	62	1	the	the	DET
dpc-2859	62	2	data	datum	NOUN
dpc-2859	62	3	obtained	obtain	VERB
dpc-2859	62	4	were	be	AUX
dpc-2859	62	5	statistically	statistically	ADV
dpc-2859	62	6	analyzed	analyze	VERB
dpc-2859	62	7	using	use	VERB
dpc-2859	62	8	the	the	DET
dpc-2859	62	9	software	software	NOUN
dpc-2859	62	10	program	program	NOUN
dpc-2859	62	11	spss	spss	PROPN
dpc-2859	62	12	22.0	22.0	NUM
dpc-2859	62	13	.	.	PUNCT
dpc-2859	63	1	continuous	continuous	ADJ
dpc-2859	63	2	variables	variable	NOUN
dpc-2859	63	3	were	be	AUX
dpc-2859	63	4	expressed	express	VERB
dpc-2859	63	5	as	as	ADP
dpc-2859	63	6	mean	mean	NOUN
dpc-2859	63	7	±	±	NUM
dpc-2859	63	8	standard	standard	ADJ
dpc-2859	63	9	deviation	deviation	NOUN
dpc-2859	63	10	,	,	PUNCT
dpc-2859	63	11	and	and	CCONJ
dpc-2859	63	12	variables	variable	NOUN
dpc-2859	63	13	indicated	indicate	VERB
dpc-2859	63	14	by	by	ADP
dpc-2859	63	15	count	count	NOUN
dpc-2859	63	16	were	be	AUX
dpc-2859	63	17	expressed	express	VERB
dpc-2859	63	18	as	as	ADP
dpc-2859	63	19	percentages	percentage	NOUN
dpc-2859	63	20	.	.	PUNCT
dpc-2859	64	1	chi	chi	ADJ
dpc-2859	64	2	-	-	PUNCT
dpc-2859	64	3	square	square	ADJ
dpc-2859	64	4	tests	test	NOUN
dpc-2859	64	5	were	be	AUX
dpc-2859	64	6	used	use	VERB
dpc-2859	64	7	in	in	ADP
dpc-2859	64	8	comparisons	comparison	NOUN
dpc-2859	64	9	.	.	PUNCT
dpc-2859	65	1	results	result	NOUN
dpc-2859	65	2	of	of	ADP
dpc-2859	65	3	210	210	NUM
dpc-2859	65	4	patients	patient	NOUN
dpc-2859	65	5	included	include	VERB
dpc-2859	65	6	in	in	ADP
dpc-2859	65	7	the	the	DET
dpc-2859	65	8	study	study	NOUN
dpc-2859	65	9	,	,	PUNCT
dpc-2859	65	10	138	138	NUM
dpc-2859	65	11	(	(	PUNCT
dpc-2859	65	12	65.7	65.7	NUM
dpc-2859	65	13	%	%	NOUN
dpc-2859	65	14	)	)	PUNCT
dpc-2859	65	15	were	be	AUX
dpc-2859	65	16	female	female	ADJ
dpc-2859	65	17	and	and	CCONJ
dpc-2859	65	18	72	72	NUM
dpc-2859	65	19	(	(	PUNCT
dpc-2859	65	20	34.3	34.3	NUM
dpc-2859	65	21	%	%	NOUN
dpc-2859	65	22	)	)	PUNCT
dpc-2859	65	23	were	be	AUX
dpc-2859	65	24	male	male	ADJ
dpc-2859	65	25	,	,	PUNCT
dpc-2859	65	26	with	with	ADP
dpc-2859	65	27	a	a	DET
dpc-2859	65	28	mean	mean	ADJ
dpc-2859	65	29	age	age	NOUN
dpc-2859	65	30	of	of	ADP
dpc-2859	65	31	23.7	23.7	NUM
dpc-2859	65	32	(	(	PUNCT
dpc-2859	65	33	16	16	NUM
dpc-2859	65	34	-	-	SYM
dpc-2859	65	35	59	59	NUM
dpc-2859	65	36	)	)	PUNCT
dpc-2859	65	37	.	.	PUNCT
dpc-2859	66	1	mean	mean	VERB
dpc-2859	66	2	body	body	NOUN
dpc-2859	66	3	weight	weight	NOUN
dpc-2859	66	4	of	of	ADP
dpc-2859	66	5	the	the	DET
dpc-2859	66	6	patients	patient	NOUN
dpc-2859	66	7	was	be	AUX
dpc-2859	66	8	62.1	62.1	NUM
dpc-2859	66	9	(	(	PUNCT
dpc-2859	66	10	38	38	NUM
dpc-2859	66	11	-	-	SYM
dpc-2859	66	12	105	105	NUM
dpc-2859	66	13	)	)	PUNCT
dpc-2859	66	14	kg	kg	NOUN
dpc-2859	66	15	.	.	PUNCT
dpc-2859	67	1	the	the	DET
dpc-2859	67	2	dose	dose	PROPN
dpc-2859	67	3	of	of	ADP
dpc-2859	67	4	isotretinoin	isotretinoin	PROPN
dpc-2859	67	5	ranged	range	VERB
dpc-2859	67	6	from	from	ADP
dpc-2859	67	7	20	20	NUM
dpc-2859	67	8	to	to	PART
dpc-2859	67	9	70	70	NUM
dpc-2859	67	10	mg	mg	NUM
dpc-2859	67	11	/	/	SYM
dpc-2859	67	12	day	day	NOUN
dpc-2859	67	13	.	.	PUNCT
dpc-2859	68	1	original	original	ADJ
dpc-2859	68	2	article	article	NOUN
dpc-2859	68	3	|	|	ADV
dpc-2859	68	4	dermatol	dermatol	ADJ
dpc-2859	68	5	pract	pract	NOUN
dpc-2859	68	6	concept	concept	NOUN
dpc-2859	68	7	.	.	PUNCT
dpc-2859	69	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	69	2	3	3	NUM
dpc-2859	69	3	the	the	DET
dpc-2859	69	4	treatment	treatment	NOUN
dpc-2859	69	5	was	be	AUX
dpc-2859	69	6	regulated	regulate	VERB
dpc-2859	69	7	in	in	ADP
dpc-2859	69	8	such	such	DET
dpc-2859	69	9	a	a	DET
dpc-2859	69	10	way	way	NOUN
dpc-2859	69	11	that	that	SCONJ
dpc-2859	69	12	59.2	59.2	NUM
dpc-2859	69	13	%	%	NOUN
dpc-2859	69	14	of	of	ADP
dpc-2859	69	15	our	our	PRON
dpc-2859	69	16	patients	patient	NOUN
dpc-2859	69	17	received	receive	VERB
dpc-2859	69	18	30	30	NUM
dpc-2859	69	19	mg	mg	PROPN
dpc-2859	69	20	/	/	SYM
dpc-2859	69	21	kg	kg	NOUN
dpc-2859	69	22	/	/	SYM
dpc-2859	69	23	day	day	NOUN
dpc-2859	69	24	and	and	CCONJ
dpc-2859	69	25	36	36	NUM
dpc-2859	69	26	%	%	NOUN
dpc-2859	69	27	received	receive	VERB
dpc-2859	69	28	40	40	NUM
dpc-2859	69	29	/	/	SYM
dpc-2859	69	30	mg	mg	PROPN
dpc-2859	69	31	/	/	SYM
dpc-2859	69	32	kg	kg	PROPN
dpc-2859	69	33	/	/	SYM
dpc-2859	69	34	day	day	NOUN
dpc-2859	69	35	.	.	PUNCT
dpc-2859	70	1	the	the	DET
dpc-2859	70	2	average	average	ADJ
dpc-2859	70	3	duration	duration	NOUN
dpc-2859	70	4	of	of	ADP
dpc-2859	70	5	drug	drug	NOUN
dpc-2859	70	6	use	use	NOUN
dpc-2859	70	7	by	by	ADP
dpc-2859	70	8	patients	patient	NOUN
dpc-2859	70	9	was	be	AUX
dpc-2859	70	10	detected	detect	VERB
dpc-2859	70	11	to	to	PART
dpc-2859	70	12	be	be	AUX
dpc-2859	70	13	5.36	5.36	NUM
dpc-2859	70	14	months	month	NOUN
dpc-2859	70	15	.	.	PUNCT
dpc-2859	71	1	the	the	DET
dpc-2859	71	2	most	most	ADV
dpc-2859	71	3	common	common	ADJ
dpc-2859	71	4	adverse	adverse	ADJ
dpc-2859	71	5	event	event	NOUN
dpc-2859	71	6	of	of	ADP
dpc-2859	71	7	isotretinoin	isotretinoin	PROPN
dpc-2859	71	8	was	be	AUX
dpc-2859	71	9	dry	dry	ADJ
dpc-2859	71	10	lips	lip	NOUN
dpc-2859	71	11	in	in	ADP
dpc-2859	71	12	206	206	NUM
dpc-2859	71	13	(	(	PUNCT
dpc-2859	71	14	98.1	98.1	NUM
dpc-2859	71	15	%	%	NOUN
dpc-2859	71	16	)	)	PUNCT
dpc-2859	71	17	patients	patient	NOUN
dpc-2859	71	18	.	.	PUNCT
dpc-2859	72	1	then	then	ADV
dpc-2859	72	2	,	,	PUNCT
dpc-2859	72	3	dry	dry	ADJ
dpc-2859	72	4	eye	eye	NOUN
dpc-2859	72	5	87	87	NUM
dpc-2859	72	6	(	(	PUNCT
dpc-2859	72	7	41.4	41.4	NUM
dpc-2859	72	8	%	%	NOUN
dpc-2859	72	9	)	)	PUNCT
dpc-2859	72	10	,	,	PUNCT
dpc-2859	72	11	nosebleed	nosebleed	VERB
dpc-2859	72	12	73	73	NUM
dpc-2859	72	13	(	(	PUNCT
dpc-2859	72	14	34.7	34.7	NUM
dpc-2859	72	15	%	%	NOUN
dpc-2859	72	16	)	)	PUNCT
dpc-2859	72	17	,	,	PUNCT
dpc-2859	72	18	muscle	muscle	NOUN
dpc-2859	72	19	pain	pain	NOUN
dpc-2859	72	20	58	58	NUM
dpc-2859	72	21	(	(	PUNCT
dpc-2859	72	22	27.6	27.6	NUM
dpc-2859	72	23	%	%	NOUN
dpc-2859	72	24	)	)	PUNCT
dpc-2859	72	25	,	,	PUNCT
dpc-2859	72	26	malaise	malaise	NOUN
dpc-2859	72	27	56	56	NUM
dpc-2859	72	28	(	(	PUNCT
dpc-2859	72	29	26.6	26.6	NUM
dpc-2859	72	30	%	%	NOUN
dpc-2859	72	31	)	)	PUNCT
dpc-2859	72	32	,	,	PUNCT
dpc-2859	72	33	facial	facial	ADJ
dpc-2859	72	34	erythema	erythema	NOUN
dpc-2859	72	35	39	39	NUM
dpc-2859	72	36	(	(	PUNCT
dpc-2859	72	37	18.5	18.5	NUM
dpc-2859	72	38	%	%	NOUN
dpc-2859	72	39	)	)	PUNCT
dpc-2859	72	40	,	,	PUNCT
dpc-2859	72	41	itching	itch	VERB
dpc-2859	72	42	36	36	NUM
dpc-2859	72	43	(	(	PUNCT
dpc-2859	72	44	17.1	17.1	NUM
dpc-2859	72	45	%	%	NOUN
dpc-2859	72	46	)	)	PUNCT
dpc-2859	72	47	,	,	PUNCT
dpc-2859	72	48	constipation	constipation	NOUN
dpc-2859	72	49	36	36	NUM
dpc-2859	72	50	(	(	PUNCT
dpc-2859	72	51	17.1	17.1	NUM
dpc-2859	72	52	%	%	NOUN
dpc-2859	72	53	)	)	PUNCT
dpc-2859	72	54	,	,	PUNCT
dpc-2859	72	55	xerosis	xerosis	NOUN
dpc-2859	72	56	30	30	NUM
dpc-2859	72	57	(	(	PUNCT
dpc-2859	72	58	14.2	14.2	NUM
dpc-2859	72	59	%	%	NOUN
dpc-2859	72	60	)	)	PUNCT
dpc-2859	72	61	,	,	PUNCT
dpc-2859	72	62	sun	sun	NOUN
dpc-2859	72	63	sensitivity	sensitivity	NOUN
dpc-2859	72	64	21	21	NUM
dpc-2859	72	65	(	(	PUNCT
dpc-2859	72	66	10	10	NUM
dpc-2859	72	67	%	%	NOUN
dpc-2859	72	68	)	)	PUNCT
dpc-2859	72	69	,	,	PUNCT
dpc-2859	72	70	joint	joint	ADJ
dpc-2859	72	71	pain	pain	NOUN
dpc-2859	72	72	17	17	NUM
dpc-2859	72	73	(	(	PUNCT
dpc-2859	72	74	8.9	8.9	NUM
dpc-2859	72	75	%	%	NOUN
dpc-2859	72	76	)	)	PUNCT
dpc-2859	72	77	,	,	PUNCT
dpc-2859	72	78	anal	anal	NOUN
dpc-2859	72	79	bleeding	bleed	VERB
dpc-2859	72	80	18	18	NUM
dpc-2859	72	81	(	(	PUNCT
dpc-2859	72	82	8.6	8.6	NUM
dpc-2859	72	83	%	%	NOUN
dpc-2859	72	84	)	)	PUNCT
dpc-2859	72	85	,	,	PUNCT
dpc-2859	72	86	headache	headache	NOUN
dpc-2859	72	87	18	18	NUM
dpc-2859	72	88	(	(	PUNCT
dpc-2859	72	89	8.6	8.6	NUM
dpc-2859	72	90	%	%	NOUN
dpc-2859	72	91	)	)	PUNCT
dpc-2859	72	92	,	,	PUNCT
dpc-2859	72	93	hair	hair	NOUN
dpc-2859	72	94	loss	loss	NOUN
dpc-2859	72	95	15	15	NUM
dpc-2859	72	96	(	(	PUNCT
dpc-2859	72	97	7.1	7.1	NUM
dpc-2859	72	98	%	%	NOUN
dpc-2859	72	99	)	)	PUNCT
dpc-2859	72	100	,	,	PUNCT
dpc-2859	72	101	mucosal	mucosal	NOUN
dpc-2859	72	102	erosion	erosion	NOUN
dpc-2859	72	103	10	10	NUM
dpc-2859	72	104	(	(	PUNCT
dpc-2859	72	105	4.7	4.7	NUM
dpc-2859	72	106	%	%	NOUN
dpc-2859	72	107	)	)	PUNCT
dpc-2859	72	108	,	,	PUNCT
dpc-2859	72	109	mental	mental	ADJ
dpc-2859	72	110	change	change	NOUN
dpc-2859	72	111	9	9	NUM
dpc-2859	72	112	(	(	PUNCT
dpc-2859	72	113	4.2	4.2	NUM
dpc-2859	72	114	%	%	NOUN
dpc-2859	72	115	)	)	PUNCT
dpc-2859	72	116	,	,	PUNCT
dpc-2859	72	117	menstrual	menstrual	ADJ
dpc-2859	72	118	irregularity	irregularity	NOUN
dpc-2859	72	119	8	8	NUM
dpc-2859	72	120	(	(	PUNCT
dpc-2859	72	121	3.8	3.8	NUM
dpc-2859	72	122	%	%	NOUN
dpc-2859	72	123	)	)	PUNCT
dpc-2859	72	124	and	and	CCONJ
dpc-2859	72	125	anal	anal	ADJ
dpc-2859	72	126	fissure	fissure	NOUN
dpc-2859	72	127	7	7	NUM
dpc-2859	72	128	(	(	PUNCT
dpc-2859	72	129	3.3	3.3	NUM
dpc-2859	72	130	%	%	NOUN
dpc-2859	72	131	)	)	PUNCT
dpc-2859	72	132	were	be	AUX
dpc-2859	72	133	observed	observe	VERB
dpc-2859	72	134	,	,	PUNCT
dpc-2859	72	135	respectively	respectively	ADV
dpc-2859	72	136	(	(	PUNCT
dpc-2859	72	137	table	table	NOUN
dpc-2859	72	138	1	1	NUM
dpc-2859	72	139	)	)	PUNCT
dpc-2859	72	140	.	.	PUNCT
dpc-2859	73	1	no	no	DET
dpc-2859	73	2	patient	patient	NOUN
dpc-2859	73	3	experienced	experience	VERB
dpc-2859	73	4	abdominal	abdominal	ADJ
dpc-2859	73	5	pain	pain	NOUN
dpc-2859	73	6	.	.	PUNCT
dpc-2859	74	1	five	five	NUM
dpc-2859	74	2	of	of	ADP
dpc-2859	74	3	the	the	DET
dpc-2859	74	4	patients	patient	NOUN
dpc-2859	74	5	who	who	PRON
dpc-2859	74	6	developed	develop	VERB
dpc-2859	74	7	anal	anal	ADJ
dpc-2859	74	8	fissure	fissure	NOUN
dpc-2859	74	9	were	be	AUX
dpc-2859	74	10	female	female	ADJ
dpc-2859	74	11	and	and	CCONJ
dpc-2859	74	12	2	2	NUM
dpc-2859	74	13	were	be	AUX
dpc-2859	74	14	male	male	ADJ
dpc-2859	74	15	,	,	PUNCT
dpc-2859	74	16	and	and	CCONJ
dpc-2859	74	17	all	all	PRON
dpc-2859	74	18	had	have	VERB
dpc-2859	74	19	fissure	fissure	NOUN
dpc-2859	74	20	with	with	ADP
dpc-2859	74	21	constipation	constipation	NOUN
dpc-2859	74	22	and	and	CCONJ
dpc-2859	74	23	anal	anal	ADJ
dpc-2859	74	24	bleeding	bleeding	NOUN
dpc-2859	74	25	.	.	PUNCT
dpc-2859	75	1	only	only	ADV
dpc-2859	75	2	2	2	NUM
dpc-2859	75	3	of	of	ADP
dpc-2859	75	4	10	10	NUM
dpc-2859	75	5	patients	patient	NOUN
dpc-2859	75	6	with	with	ADP
dpc-2859	75	7	mucosal	mucosal	NOUN
dpc-2859	75	8	erosion	erosion	NOUN
dpc-2859	75	9	had	have	VERB
dpc-2859	75	10	constipation	constipation	NOUN
dpc-2859	75	11	.	.	PUNCT
dpc-2859	76	1	in	in	ADP
dpc-2859	76	2	patients	patient	NOUN
dpc-2859	76	3	with	with	ADP
dpc-2859	76	4	fissure	fissure	NOUN
dpc-2859	76	5	and	and	CCONJ
dpc-2859	76	6	mucosal	mucosal	NOUN
dpc-2859	76	7	erosion	erosion	NOUN
dpc-2859	76	8	,	,	PUNCT
dpc-2859	76	9	the	the	DET
dpc-2859	76	10	isotretinoin	isotretinoin	PROPN
dpc-2859	76	11	dose	dose	NOUN
dpc-2859	76	12	ranged	range	VERB
dpc-2859	76	13	from	from	ADP
dpc-2859	76	14	30	30	NUM
dpc-2859	76	15	-	-	SYM
dpc-2859	76	16	70	70	NUM
dpc-2859	76	17	mg	mg	PROPN
dpc-2859	76	18	/	/	SYM
dpc-2859	76	19	day	day	NOUN
dpc-2859	76	20	.	.	PUNCT
dpc-2859	77	1	it	it	PRON
dpc-2859	77	2	was	be	AUX
dpc-2859	77	3	determined	determine	VERB
dpc-2859	77	4	that	that	SCONJ
dpc-2859	77	5	8	8	NUM
dpc-2859	77	6	of	of	ADP
dpc-2859	77	7	36	36	NUM
dpc-2859	77	8	cases	case	NOUN
dpc-2859	77	9	with	with	ADP
dpc-2859	77	10	constipation	constipation	NOUN
dpc-2859	77	11	already	already	ADV
dpc-2859	77	12	had	have	VERB
dpc-2859	77	13	constipation	constipation	NOUN
dpc-2859	77	14	before	before	ADP
dpc-2859	77	15	treatment	treatment	NOUN
dpc-2859	77	16	.	.	PUNCT
dpc-2859	78	1	the	the	DET
dpc-2859	78	2	comparison	comparison	NOUN
dpc-2859	78	3	between	between	ADP
dpc-2859	78	4	gender	gender	NOUN
dpc-2859	78	5	and	and	CCONJ
dpc-2859	78	6	anal	anal	ADJ
dpc-2859	78	7	bleeding	bleeding	NOUN
dpc-2859	78	8	revealed	reveal	VERB
dpc-2859	78	9	that	that	SCONJ
dpc-2859	78	10	anal	anal	ADJ
dpc-2859	78	11	bleeding	bleeding	NOUN
dpc-2859	78	12	was	be	AUX
dpc-2859	78	13	more	more	ADV
dpc-2859	78	14	common	common	ADJ
dpc-2859	78	15	in	in	ADP
dpc-2859	78	16	women	woman	NOUN
dpc-2859	78	17	(	(	PUNCT
dpc-2859	78	18	p	p	X
dpc-2859	78	19	=	=	NOUN
dpc-2859	78	20	0.029	0.029	NUM
dpc-2859	78	21	)	)	PUNCT
dpc-2859	78	22	.	.	PUNCT
dpc-2859	79	1	in	in	ADP
dpc-2859	79	2	addition	addition	NOUN
dpc-2859	79	3	,	,	PUNCT
dpc-2859	79	4	no	no	DET
dpc-2859	79	5	statistically	statistically	ADV
dpc-2859	79	6	significant	significant	ADJ
dpc-2859	79	7	difference	difference	NOUN
dpc-2859	79	8	was	be	AUX
dpc-2859	79	9	observed	observe	VERB
dpc-2859	79	10	between	between	ADP
dpc-2859	79	11	gender	gender	NOUN
dpc-2859	79	12	and	and	CCONJ
dpc-2859	79	13	constipation	constipation	NOUN
dpc-2859	79	14	(	(	PUNCT
dpc-2859	79	15	p	p	X
dpc-2859	79	16	=	=	NOUN
dpc-2859	79	17	0.226	0.226	NUM
dpc-2859	79	18	)	)	PUNCT
dpc-2859	79	19	,	,	PUNCT
dpc-2859	79	20	drug	drug	NOUN
dpc-2859	79	21	dose	dose	NOUN
dpc-2859	79	22	given	give	VERB
dpc-2859	79	23	and	and	CCONJ
dpc-2859	79	24	constipation	constipation	NOUN
dpc-2859	79	25	(	(	PUNCT
dpc-2859	79	26	p	p	NOUN
dpc-2859	79	27	=	=	NOUN
dpc-2859	79	28	0.067	0.067	NUM
dpc-2859	79	29	)	)	PUNCT
dpc-2859	79	30	,	,	PUNCT
dpc-2859	79	31	drug	drug	NOUN
dpc-2859	79	32	dose	dose	NOUN
dpc-2859	79	33	given	give	VERB
dpc-2859	79	34	and	and	CCONJ
dpc-2859	79	35	anal	anal	ADJ
dpc-2859	79	36	bleeding	bleeding	NOUN
dpc-2859	79	37	(	(	PUNCT
dpc-2859	79	38	p	p	X
dpc-2859	79	39	=	=	NOUN
dpc-2859	79	40	0.290	0.290	NUM
dpc-2859	79	41	)	)	PUNCT
dpc-2859	79	42	and	and	CCONJ
dpc-2859	79	43	drug	drug	NOUN
dpc-2859	79	44	dose	dose	NOUN
dpc-2859	79	45	given	give	VERB
dpc-2859	79	46	and	and	CCONJ
dpc-2859	79	47	fissure	fissure	VERB
dpc-2859	79	48	formation	formation	NOUN
dpc-2859	79	49	(	(	PUNCT
dpc-2859	79	50	p	p	X
dpc-2859	79	51	=	=	NOUN
dpc-2859	79	52	0.835	0.835	NUM
dpc-2859	79	53	)	)	PUNCT
dpc-2859	79	54	.	.	PUNCT
dpc-2859	80	1	there	there	PRON
dpc-2859	80	2	was	be	VERB
dpc-2859	80	3	no	no	DET
dpc-2859	80	4	history	history	NOUN
dpc-2859	80	5	of	of	ADP
dpc-2859	80	6	ibd	ibd	NOUN
dpc-2859	80	7	in	in	ADP
dpc-2859	80	8	patients	patient	NOUN
dpc-2859	80	9	or	or	CCONJ
dpc-2859	80	10	their	their	PRON
dpc-2859	80	11	families	family	NOUN
dpc-2859	80	12	.	.	PUNCT
dpc-2859	81	1	in	in	ADP
dpc-2859	81	2	12	12	NUM
dpc-2859	81	3	of	of	ADP
dpc-2859	81	4	the	the	DET
dpc-2859	81	5	210	210	NUM
dpc-2859	81	6	patients	patient	NOUN
dpc-2859	81	7	(	(	PUNCT
dpc-2859	81	8	5.7	5.7	NUM
dpc-2859	81	9	%	%	NOUN
dpc-2859	81	10	)	)	PUNCT
dpc-2859	81	11	enrolled	enrol	VERB
dpc-2859	81	12	in	in	ADP
dpc-2859	81	13	the	the	DET
dpc-2859	81	14	study	study	NOUN
dpc-2859	81	15	,	,	PUNCT
dpc-2859	81	16	elevations	elevation	NOUN
dpc-2859	81	17	in	in	ADP
dpc-2859	81	18	liver	liver	NOUN
dpc-2859	81	19	function	function	NOUN
dpc-2859	81	20	tests	test	NOUN
dpc-2859	81	21	were	be	AUX
dpc-2859	81	22	identified	identify	VERB
dpc-2859	81	23	,	,	PUNCT
dpc-2859	81	24	while	while	SCONJ
dpc-2859	81	25	7	7	NUM
dpc-2859	81	26	patients	patient	NOUN
dpc-2859	81	27	(	(	PUNCT
dpc-2859	81	28	3.3	3.3	NUM
dpc-2859	81	29	%	%	NOUN
dpc-2859	81	30	)	)	PUNCT
dpc-2859	81	31	had	have	VERB
dpc-2859	81	32	triglycerides	triglyceride	NOUN
dpc-2859	81	33	and	and	CCONJ
dpc-2859	81	34	3	3	NUM
dpc-2859	81	35	patients	patient	NOUN
dpc-2859	81	36	had	have	VERB
dpc-2859	81	37	high	high	ADJ
dpc-2859	81	38	cholesterol	cholesterol	NOUN
dpc-2859	81	39	(	(	PUNCT
dpc-2859	81	40	1.4	1.4	NUM
dpc-2859	81	41	%	%	NOUN
dpc-2859	81	42	)	)	PUNCT
dpc-2859	81	43	.	.	PUNCT
dpc-2859	82	1	treatment	treatment	NOUN
dpc-2859	82	2	was	be	AUX
dpc-2859	82	3	discontinued	discontinue	VERB
dpc-2859	82	4	due	due	ADJ
dpc-2859	82	5	to	to	ADP
dpc-2859	82	6	elevated	elevated	ADJ
dpc-2859	82	7	liver	liver	NOUN
dpc-2859	82	8	function	function	NOUN
dpc-2859	82	9	tests	test	NOUN
dpc-2859	82	10	in	in	ADP
dpc-2859	82	11	5	5	NUM
dpc-2859	82	12	patients	patient	NOUN
dpc-2859	82	13	(	(	PUNCT
dpc-2859	82	14	2.3	2.3	NUM
dpc-2859	82	15	%	%	NOUN
dpc-2859	82	16	)	)	PUNCT
dpc-2859	82	17	,	,	PUNCT
dpc-2859	82	18	and	and	CCONJ
dpc-2859	82	19	because	because	SCONJ
dpc-2859	82	20	anal	anal	ADJ
dpc-2859	82	21	bleeding	bleeding	NOUN
dpc-2859	82	22	could	could	AUX
dpc-2859	82	23	not	not	PART
dpc-2859	82	24	be	be	AUX
dpc-2859	82	25	controlled	control	VERB
dpc-2859	82	26	in	in	ADP
dpc-2859	82	27	1	1	NUM
dpc-2859	82	28	patient	patient	NOUN
dpc-2859	82	29	.	.	PUNCT
dpc-2859	83	1	patients	patient	NOUN
dpc-2859	83	2	with	with	ADP
dpc-2859	83	3	constipation	constipation	NOUN
dpc-2859	83	4	and	and	CCONJ
dpc-2859	83	5	anal	anal	ADJ
dpc-2859	83	6	bleeding	bleeding	NOUN
dpc-2859	83	7	were	be	AUX
dpc-2859	83	8	examined	examine	VERB
dpc-2859	83	9	in	in	ADP
dpc-2859	83	10	detail	detail	NOUN
dpc-2859	83	11	by	by	ADP
dpc-2859	83	12	the	the	DET
dpc-2859	83	13	general	general	ADJ
dpc-2859	83	14	surgery	surgery	NOUN
dpc-2859	83	15	clinic	clinic	NOUN
dpc-2859	83	16	.	.	PUNCT
dpc-2859	84	1	medical	medical	ADJ
dpc-2859	84	2	treatment	treatment	NOUN
dpc-2859	84	3	,	,	PUNCT
dpc-2859	84	4	topical	topical	ADJ
dpc-2859	84	5	moisturizers	moisturizer	NOUN
dpc-2859	84	6	and	and	CCONJ
dpc-2859	84	7	appropriate	appropriate	ADJ
dpc-2859	84	8	diet	diet	NOUN
dpc-2859	84	9	were	be	AUX
dpc-2859	84	10	recommended	recommend	VERB
dpc-2859	84	11	to	to	ADP
dpc-2859	84	12	patients	patient	NOUN
dpc-2859	84	13	with	with	ADP
dpc-2859	84	14	fissure	fissure	NOUN
dpc-2859	84	15	and	and	CCONJ
dpc-2859	84	16	mucosal	mucosal	NOUN
dpc-2859	84	17	erosion	erosion	NOUN
dpc-2859	84	18	.	.	PUNCT
dpc-2859	85	1	the	the	DET
dpc-2859	85	2	dose	dose	PROPN
dpc-2859	85	3	of	of	ADP
dpc-2859	85	4	isotretinoin	isotretinoin	PROPN
dpc-2859	85	5	was	be	AUX
dpc-2859	85	6	reduced	reduce	VERB
dpc-2859	85	7	in	in	ADP
dpc-2859	85	8	three	three	NUM
dpc-2859	85	9	patients	patient	NOUN
dpc-2859	85	10	.	.	PUNCT
dpc-2859	86	1	in	in	ADP
dpc-2859	86	2	the	the	DET
dpc-2859	86	3	controls	control	NOUN
dpc-2859	86	4	,	,	PUNCT
dpc-2859	86	5	symptoms	symptom	NOUN
dpc-2859	86	6	were	be	AUX
dpc-2859	86	7	observed	observe	VERB
dpc-2859	86	8	to	to	PART
dpc-2859	86	9	improve	improve	VERB
dpc-2859	86	10	except	except	SCONJ
dpc-2859	86	11	for	for	ADP
dpc-2859	86	12	one	one	NUM
dpc-2859	86	13	patient	patient	NOUN
dpc-2859	86	14	.	.	PUNCT
dpc-2859	87	1	conclusions	conclusion	NOUN
dpc-2859	87	2	acne	acne	NOUN
dpc-2859	87	3	vulgaris	vulgaris	NOUN
dpc-2859	87	4	is	be	AUX
dpc-2859	87	5	a	a	DET
dpc-2859	87	6	chronic	chronic	ADJ
dpc-2859	87	7	inflammatory	inflammatory	ADJ
dpc-2859	87	8	disease	disease	NOUN
dpc-2859	87	9	that	that	SCONJ
dpc-2859	87	10	primarily	primarily	ADV
dpc-2859	87	11	concerns	concern	VERB
dpc-2859	87	12	adolescents	adolescent	NOUN
dpc-2859	87	13	.	.	PUNCT
dpc-2859	88	1	this	this	DET
dpc-2859	88	2	condition	condition	NOUN
dpc-2859	88	3	,	,	PUNCT
dpc-2859	88	4	which	which	PRON
dpc-2859	88	5	affects	affect	VERB
dpc-2859	88	6	85	85	NUM
dpc-2859	88	7	%	%	NOUN
dpc-2859	88	8	of	of	ADP
dpc-2859	88	9	people	people	NOUN
dpc-2859	88	10	,	,	PUNCT
dpc-2859	88	11	is	be	AUX
dpc-2859	88	12	mostly	mostly	ADV
dpc-2859	88	13	seen	see	VERB
dpc-2859	88	14	in	in	ADP
dpc-2859	88	15	young	young	ADJ
dpc-2859	88	16	girls	girl	NOUN
dpc-2859	88	17	and	and	CCONJ
dpc-2859	88	18	boys	boy	NOUN
dpc-2859	88	19	aged	age	VERB
dpc-2859	88	20	[	[	X
dpc-2859	88	21	15,16	15,16	NUM
dpc-2859	88	22	]	]	PUNCT
dpc-2859	88	23	.	.	PUNCT
dpc-2859	89	1	acne	acne	NOUN
dpc-2859	89	2	vulgaris	vulgaris	NOUN
dpc-2859	89	3	is	be	AUX
dpc-2859	89	4	treated	treat	VERB
dpc-2859	89	5	with	with	ADP
dpc-2859	89	6	the	the	DET
dpc-2859	89	7	use	use	NOUN
dpc-2859	89	8	of	of	ADP
dpc-2859	89	9	topical	topical	ADJ
dpc-2859	89	10	treatments	treatment	NOUN
dpc-2859	89	11	alone	alone	ADJ
dpc-2859	89	12	or	or	CCONJ
dpc-2859	89	13	topical	topical	ADJ
dpc-2859	89	14	and	and	CCONJ
dpc-2859	89	15	systemic	systemic	ADJ
dpc-2859	89	16	treatments	treatment	NOUN
dpc-2859	89	17	in	in	ADP
dpc-2859	89	18	combination	combination	NOUN
dpc-2859	89	19	,	,	PUNCT
dpc-2859	89	20	depending	depend	VERB
dpc-2859	89	21	on	on	ADP
dpc-2859	89	22	the	the	DET
dpc-2859	89	23	severity	severity	NOUN
dpc-2859	89	24	of	of	ADP
dpc-2859	89	25	the	the	DET
dpc-2859	89	26	disease	disease	NOUN
dpc-2859	90	1	[	[	X
dpc-2859	90	2	5,6,16,17	5,6,16,17	NOUN
dpc-2859	90	3	]	]	PUNCT
dpc-2859	90	4	.	.	PUNCT
dpc-2859	91	1	isotretinoin	isotretinoin	PROPN
dpc-2859	91	2	,	,	PUNCT
dpc-2859	91	3	which	which	PRON
dpc-2859	91	4	is	be	AUX
dpc-2859	91	5	a	a	DET
dpc-2859	91	6	synthetic	synthetic	ADJ
dpc-2859	91	7	retinoid	retinoid	NOUN
dpc-2859	91	8	,	,	PUNCT
dpc-2859	91	9	has	have	AUX
dpc-2859	91	10	been	be	AUX
dpc-2859	91	11	used	use	VERB
dpc-2859	91	12	for	for	ADP
dpc-2859	91	13	many	many	ADJ
dpc-2859	91	14	years	year	NOUN
dpc-2859	91	15	to	to	PART
dpc-2859	91	16	treat	treat	VERB
dpc-2859	91	17	nodulocystic	nodulocystic	ADJ
dpc-2859	91	18	acne	acne	NOUN
dpc-2859	91	19	.	.	PUNCT
dpc-2859	92	1	today	today	NOUN
dpc-2859	92	2	,	,	PUNCT
dpc-2859	92	3	it	it	PRON
dpc-2859	92	4	is	be	AUX
dpc-2859	92	5	used	use	VERB
dpc-2859	92	6	in	in	ADP
dpc-2859	92	7	the	the	DET
dpc-2859	92	8	treatment	treatment	NOUN
dpc-2859	92	9	of	of	ADP
dpc-2859	92	10	moderate	moderate	ADJ
dpc-2859	92	11	to	to	ADP
dpc-2859	92	12	severe	severe	ADJ
dpc-2859	92	13	acne	acne	NOUN
dpc-2859	92	14	,	,	PUNCT
dpc-2859	92	15	severe	severe	ADJ
dpc-2859	92	16	seborrheic	seborrheic	PROPN
dpc-2859	92	17	dermatitis	dermatitis	NOUN
dpc-2859	92	18	,	,	PUNCT
dpc-2859	92	19	pyoderma	pyoderma	NOUN
dpc-2859	92	20	faciale	faciale	NOUN
dpc-2859	92	21	and	and	CCONJ
dpc-2859	92	22	gram	gram	NOUN
dpc-2859	92	23	-	-	PUNCT
dpc-2859	92	24	negative	negative	ADJ
dpc-2859	92	25	folliculitis	folliculitis	NOUN
dpc-2859	92	26	,	,	PUNCT
dpc-2859	92	27	unresponsive	unresponsive	ADJ
dpc-2859	92	28	to	to	ADP
dpc-2859	92	29	other	other	ADJ
dpc-2859	92	30	treatments	treatment	NOUN
dpc-2859	92	31	,	,	PUNCT
dpc-2859	92	32	including	include	VERB
dpc-2859	92	33	oral	oral	ADJ
dpc-2859	92	34	antibiotics	antibiotic	NOUN
dpc-2859	92	35	.	.	PUNCT
dpc-2859	93	1	isotretinoin	isotretinoin	PROPN
dpc-2859	93	2	is	be	AUX
dpc-2859	93	3	the	the	DET
dpc-2859	93	4	only	only	ADJ
dpc-2859	93	5	drug	drug	NOUN
dpc-2859	93	6	effective	effective	ADJ
dpc-2859	93	7	on	on	ADP
dpc-2859	93	8	all	all	DET
dpc-2859	93	9	factors	factor	NOUN
dpc-2859	93	10	involved	involve	VERB
dpc-2859	93	11	in	in	ADP
dpc-2859	93	12	the	the	DET
dpc-2859	93	13	pathogenesis	pathogenesis	NOUN
dpc-2859	93	14	of	of	ADP
dpc-2859	93	15	acne	acne	NOUN
dpc-2859	93	16	vulgaris	vulgaris	NOUN
dpc-2859	93	17	and	and	CCONJ
dpc-2859	93	18	is	be	AUX
dpc-2859	93	19	the	the	DET
dpc-2859	93	20	most	most	ADV
dpc-2859	93	21	effective	effective	ADJ
dpc-2859	93	22	treatment	treatment	NOUN
dpc-2859	93	23	tool	tool	NOUN
dpc-2859	93	24	in	in	ADP
dpc-2859	93	25	the	the	DET
dpc-2859	93	26	treatment	treatment	NOUN
dpc-2859	93	27	of	of	ADP
dpc-2859	93	28	acne	acne	NOUN
dpc-2859	93	29	vulgaris	vulgaris	NOUN
dpc-2859	93	30	with	with	ADP
dpc-2859	93	31	a	a	DET
dpc-2859	93	32	remission	remission	NOUN
dpc-2859	93	33	rate	rate	NOUN
dpc-2859	93	34	of	of	ADP
dpc-2859	93	35	up	up	ADP
dpc-2859	93	36	to	to	PART
dpc-2859	93	37	70%-89	70%-89	NUM
dpc-2859	93	38	%	%	NOUN
dpc-2859	93	39	[	[	X
dpc-2859	93	40	18	18	NUM
dpc-2859	93	41	-	-	SYM
dpc-2859	93	42	20	20	NUM
dpc-2859	93	43	]	]	PUNCT
dpc-2859	93	44	.	.	PUNCT
dpc-2859	94	1	the	the	DET
dpc-2859	94	2	most	most	ADV
dpc-2859	94	3	common	common	ADJ
dpc-2859	94	4	side	side	NOUN
dpc-2859	94	5	effects	effect	NOUN
dpc-2859	94	6	related	relate	VERB
dpc-2859	94	7	to	to	ADP
dpc-2859	94	8	the	the	DET
dpc-2859	94	9	use	use	NOUN
dpc-2859	94	10	of	of	ADP
dpc-2859	94	11	isotretinoin	isotretinoin	PROPN
dpc-2859	94	12	have	have	VERB
dpc-2859	94	13	mucocutaneous	mucocutaneous	ADJ
dpc-2859	94	14	characteristics	characteristic	NOUN
dpc-2859	94	15	.	.	PUNCT
dpc-2859	95	1	many	many	ADJ
dpc-2859	95	2	of	of	ADP
dpc-2859	95	3	these	these	DET
dpc-2859	95	4	symptoms	symptom	NOUN
dpc-2859	95	5	are	be	AUX
dpc-2859	95	6	tolerable	tolerable	ADJ
dpc-2859	95	7	,	,	PUNCT
dpc-2859	95	8	treatable	treatable	ADJ
dpc-2859	95	9	,	,	PUNCT
dpc-2859	95	10	and	and	CCONJ
dpc-2859	95	11	dose	dose	NOUN
dpc-2859	95	12	-	-	PUNCT
dpc-2859	95	13	dependent	dependent	NOUN
dpc-2859	95	14	  	  	SPACE
dpc-2859	96	1	[	[	X
dpc-2859	96	2	19	19	NUM
dpc-2859	96	3	]	]	PUNCT
dpc-2859	96	4	.	.	PUNCT
dpc-2859	97	1	cheilitis	cheilitis	NOUN
dpc-2859	97	2	,	,	PUNCT
dpc-2859	97	3	dry	dry	ADJ
dpc-2859	97	4	nasal	nasal	NOUN
dpc-2859	97	5	,	,	PUNCT
dpc-2859	97	6	dry	dry	ADJ
dpc-2859	97	7	eyes	eye	NOUN
dpc-2859	97	8	are	be	AUX
dpc-2859	97	9	the	the	DET
dpc-2859	97	10	most	most	ADV
dpc-2859	97	11	common	common	ADJ
dpc-2859	97	12	finding	finding	NOUN
dpc-2859	97	13	and	and	CCONJ
dpc-2859	97	14	occurs	occur	VERB
dpc-2859	97	15	in	in	ADP
dpc-2859	97	16	almost	almost	ADV
dpc-2859	97	17	all	all	DET
dpc-2859	97	18	patients	patient	NOUN
dpc-2859	97	19	.	.	PUNCT
dpc-2859	98	1	apart	apart	ADV
dpc-2859	98	2	from	from	ADP
dpc-2859	98	3	these	these	DET
dpc-2859	98	4	side	side	NOUN
dpc-2859	98	5	effects	effect	NOUN
dpc-2859	98	6	,	,	PUNCT
dpc-2859	98	7	facial	facial	ADJ
dpc-2859	98	8	erythema	erythema	NOUN
dpc-2859	98	9	,	,	PUNCT
dpc-2859	98	10	muscle	muscle	NOUN
dpc-2859	98	11	aches	ache	VERB
dpc-2859	98	12	,	,	PUNCT
dpc-2859	98	13	itching	itching	NOUN
dpc-2859	98	14	,	,	PUNCT
dpc-2859	98	15	malaise	malaise	NOUN
dpc-2859	98	16	,	,	PUNCT
dpc-2859	98	17	joint	joint	ADJ
dpc-2859	98	18	pain	pain	NOUN
dpc-2859	98	19	and	and	CCONJ
dpc-2859	98	20	headache	headache	NOUN
dpc-2859	98	21	are	be	AUX
dpc-2859	98	22	other	other	ADJ
dpc-2859	98	23	common	common	ADJ
dpc-2859	98	24	side	side	NOUN
dpc-2859	98	25	effects	effect	NOUN
dpc-2859	98	26	[	[	X
dpc-2859	98	27	21	21	NUM
dpc-2859	98	28	-	-	SYM
dpc-2859	98	29	25	25	NUM
dpc-2859	98	30	]	]	PUNCT
dpc-2859	98	31	.	.	PUNCT
dpc-2859	99	1	many	many	ADJ
dpc-2859	99	2	studies	study	NOUN
dpc-2859	99	3	have	have	AUX
dpc-2859	99	4	been	be	AUX
dpc-2859	99	5	conducted	conduct	VERB
dpc-2859	99	6	on	on	ADP
dpc-2859	99	7	gis	gis	PROPN
dpc-2859	99	8	side	side	NOUN
dpc-2859	99	9	effects	effect	NOUN
dpc-2859	99	10	of	of	ADP
dpc-2859	99	11	systemic	systemic	ADJ
dpc-2859	99	12	isotretinoin	isotretinoin	NOUN
dpc-2859	99	13	.	.	PUNCT
dpc-2859	100	1	first	first	ADV
dpc-2859	100	2	,	,	PUNCT
dpc-2859	100	3	martin	martin	PROPN
dpc-2859	100	4	et	et	PROPN
dpc-2859	100	5	al	al	PROPN
dpc-2859	100	6	reported	report	VERB
dpc-2859	100	7	a	a	DET
dpc-2859	100	8	case	case	NOUN
dpc-2859	100	9	of	of	ADP
dpc-2859	100	10	isotretinoin	isotretinoin	PROPN
dpc-2859	100	11	-	-	PUNCT
dpc-2859	100	12	related	relate	VERB
dpc-2859	100	13	proctosigmoiditis	proctosigmoiditis	NOUN
dpc-2859	100	14	in	in	ADP
dpc-2859	100	15	1987	1987	NUM
dpc-2859	100	16	[	[	X
dpc-2859	100	17	13	13	NUM
dpc-2859	100	18	]	]	PUNCT
dpc-2859	100	19	.	.	PUNCT
dpc-2859	101	1	several	several	ADJ
dpc-2859	101	2	other	other	ADJ
dpc-2859	101	3	cases	case	NOUN
dpc-2859	101	4	of	of	ADP
dpc-2859	101	5	isotretinoin	isotretinoin	PROPN
dpc-2859	101	6	-	-	PUNCT
dpc-2859	101	7	related	relate	VERB
dpc-2859	101	8	ibd	ibd	NOUN
dpc-2859	101	9	have	have	AUX
dpc-2859	101	10	been	be	AUX
dpc-2859	101	11	reported	report	VERB
dpc-2859	101	12	afterwards	afterwards	ADV
dpc-2859	101	13	.	.	PUNCT
dpc-2859	102	1	this	this	PRON
dpc-2859	102	2	suggests	suggest	VERB
dpc-2859	102	3	that	that	SCONJ
dpc-2859	102	4	isotretinoin	isotretinoin	PROPN
dpc-2859	102	5	affects	affect	VERB
dpc-2859	102	6	the	the	DET
dpc-2859	102	7	intestinal	intestinal	ADJ
dpc-2859	102	8	mucosa	mucosa	NOUN
dpc-2859	103	1	[	[	X
dpc-2859	103	2	13,14,17,26	13,14,17,26	NUM
dpc-2859	103	3	]	]	PUNCT
dpc-2859	103	4	.	.	PUNCT
dpc-2859	104	1	passier	passier	PROPN
dpc-2859	104	2	et	et	PROPN
dpc-2859	104	3	al	al	PROPN
dpc-2859	104	4	thought	think	VERB
dpc-2859	104	5	that	that	SCONJ
dpc-2859	104	6	three	three	NUM
dpc-2859	104	7	patients	patient	NOUN
dpc-2859	104	8	receiving	receive	VERB
dpc-2859	104	9	isotretinoin	isotretinoin	NOUN
dpc-2859	104	10	with	with	ADP
dpc-2859	104	11	gastrointestinal	gastrointestinal	ADJ
dpc-2859	104	12	system	system	NOUN
dpc-2859	104	13	complaints	complaint	NOUN
dpc-2859	104	14	might	might	AUX
dpc-2859	104	15	have	have	VERB
dpc-2859	104	16	ibd	ibd	NOUN
dpc-2859	104	17	,	,	PUNCT
dpc-2859	104	18	and	and	CCONJ
dpc-2859	104	19	in	in	ADP
dpc-2859	104	20	the	the	DET
dpc-2859	104	21	colonoscopy	colonoscopy	NOUN
dpc-2859	104	22	examination	examination	NOUN
dpc-2859	104	23	,	,	PUNCT
dpc-2859	104	24	ulcerative	ulcerative	ADJ
dpc-2859	104	25	colitis	colitis	NOUN
dpc-2859	104	26	was	be	AUX
dpc-2859	104	27	detected	detect	VERB
dpc-2859	104	28	in	in	ADP
dpc-2859	104	29	two	two	NUM
dpc-2859	104	30	patients	patient	NOUN
dpc-2859	104	31	and	and	CCONJ
dpc-2859	104	32	crohn	crohn	PROPN
dpc-2859	104	33	disease	disease	NOUN
dpc-2859	104	34	in	in	ADP
dpc-2859	104	35	one	one	NUM
dpc-2859	104	36	[	[	X
dpc-2859	104	37	27	27	NUM
dpc-2859	104	38	]	]	PUNCT
dpc-2859	104	39	.	.	PUNCT
dpc-2859	105	1	however	however	ADV
dpc-2859	105	2	,	,	PUNCT
dpc-2859	105	3	in	in	ADP
dpc-2859	105	4	recent	recent	ADJ
dpc-2859	105	5	large	large	ADJ
dpc-2859	105	6	-	-	PUNCT
dpc-2859	105	7	scale	scale	NOUN
dpc-2859	105	8	studies	study	NOUN
dpc-2859	105	9	,	,	PUNCT
dpc-2859	105	10	no	no	DET
dpc-2859	105	11	relationship	relationship	NOUN
dpc-2859	105	12	between	between	ADP
dpc-2859	105	13	isotretinoin	isotretinoin	PROPN
dpc-2859	105	14	and	and	CCONJ
dpc-2859	105	15	ibd	ibd	PROPN
dpc-2859	105	16	could	could	AUX
dpc-2859	105	17	be	be	AUX
dpc-2859	105	18	demonstrated	demonstrate	VERB
dpc-2859	105	19	[	[	PUNCT
dpc-2859	105	20	28	28	NUM
dpc-2859	105	21	-	-	SYM
dpc-2859	105	22	31	31	NUM
dpc-2859	105	23	]	]	PUNCT
dpc-2859	105	24	.	.	PUNCT
dpc-2859	106	1	among	among	ADP
dpc-2859	106	2	the	the	DET
dpc-2859	106	3	rarer	rare	ADJ
dpc-2859	106	4	gis	gis	NOUN
dpc-2859	106	5	,	,	PUNCT
dpc-2859	106	6	side	side	ADJ
dpc-2859	106	7	effects	effect	NOUN
dpc-2859	106	8	of	of	ADP
dpc-2859	106	9	isotretinoin	isotretinoin	PROPN
dpc-2859	106	10	include	include	VERB
dpc-2859	106	11	appendicitis	appendicitis	NOUN
dpc-2859	106	12	,	,	PUNCT
dpc-2859	106	13	esophagitis	esophagitis	NOUN
dpc-2859	106	14	,	,	PUNCT
dpc-2859	106	15	anorexia	anorexia	NOUN
dpc-2859	106	16	and	and	CCONJ
dpc-2859	106	17	weight	weight	NOUN
dpc-2859	106	18	loss	loss	NOUN
dpc-2859	106	19	[	[	X
dpc-2859	106	20	32	32	NUM
dpc-2859	106	21	]	]	PUNCT
dpc-2859	106	22	.	.	PUNCT
dpc-2859	107	1	table	table	NOUN
dpc-2859	107	2	1	1	NUM
dpc-2859	107	3	.	.	PUNCT
dpc-2859	108	1	prevalence	prevalence	NOUN
dpc-2859	108	2	of	of	ADP
dpc-2859	108	3	adverse	adverse	ADJ
dpc-2859	108	4	effects	effect	NOUN
dpc-2859	108	5	.	.	PUNCT
dpc-2859	109	1	adverse	adverse	ADJ
dpc-2859	109	2	effect	effect	NOUN
dpc-2859	109	3	patients	patient	NOUN
dpc-2859	109	4	,	,	PUNCT
dpc-2859	109	5	n	n	CCONJ
dpc-2859	109	6	(	(	PUNCT
dpc-2859	109	7	%	%	INTJ
dpc-2859	109	8	)	)	PUNCT
dpc-2859	109	9	dry	dry	ADJ
dpc-2859	109	10	lip	lip	NOUN
dpc-2859	109	11	dry	dry	ADJ
dpc-2859	109	12	eyes	eye	NOUN
dpc-2859	109	13	nose	nose	NOUN
dpc-2859	109	14	bleeds	bleed	NOUN
dpc-2859	109	15	(	(	PUNCT
dpc-2859	109	16	epistaxis	epistaxis	ADJ
dpc-2859	109	17	)	)	PUNCT
dpc-2859	109	18	muscle	muscle	NOUN
dpc-2859	109	19	aches	ache	VERB
dpc-2859	109	20	(	(	PUNCT
dpc-2859	109	21	myalgias	myalgias	PROPN
dpc-2859	109	22	)	)	PUNCT
dpc-2859	109	23	tiredness	tiredness	NOUN
dpc-2859	109	24	facial	facial	ADJ
dpc-2859	109	25	erythema	erythema	NOUN
dpc-2859	109	26	itching	itching	NOUN
dpc-2859	109	27	of	of	ADP
dpc-2859	109	28	the	the	DET
dpc-2859	109	29	skin	skin	NOUN
dpc-2859	109	30	constipation	constipation	NOUN
dpc-2859	109	31	xerosis	xerosis	PROPN
dpc-2859	109	32	sun	sun	PROPN
dpc-2859	109	33	sensitivity	sensitivity	NOUN
dpc-2859	109	34	headaches	headache	VERB
dpc-2859	109	35	anal	anal	ADJ
dpc-2859	109	36	bleeding	bleed	VERB
dpc-2859	109	37	joint	joint	ADJ
dpc-2859	109	38	aches	ache	NOUN
dpc-2859	109	39	(	(	PUNCT
dpc-2859	109	40	arthralgias	arthralgia	NOUN
dpc-2859	109	41	)	)	PUNCT
dpc-2859	109	42	hair	hair	NOUN
dpc-2859	109	43	loss	loss	NOUN
dpc-2859	109	44	mood	mood	NOUN
dpc-2859	109	45	change	change	VERB
dpc-2859	109	46	heavy	heavy	ADJ
dpc-2859	109	47	menstrual	menstrual	ADJ
dpc-2859	109	48	periods	period	NOUN
dpc-2859	109	49	anal	anal	ADJ
dpc-2859	109	50	fissure	fissure	NOUN
dpc-2859	109	51	herpes	herpe	NOUN
dpc-2859	109	52	simplex	simplex	NOUN
dpc-2859	109	53	abdominal	abdominal	ADJ
dpc-2859	109	54	pain	pain	NOUN
dpc-2859	109	55	206	206	NUM
dpc-2859	109	56	(	(	PUNCT
dpc-2859	109	57	98.1	98.1	NUM
dpc-2859	109	58	%	%	NOUN
dpc-2859	109	59	)	)	PUNCT
dpc-2859	109	60	87	87	NUM
dpc-2859	109	61	(	(	PUNCT
dpc-2859	109	62	41.4	41.4	NUM
dpc-2859	109	63	%	%	NOUN
dpc-2859	109	64	)	)	PUNCT
dpc-2859	109	65	73	73	NUM
dpc-2859	109	66	(	(	PUNCT
dpc-2859	109	67	34.7	34.7	NUM
dpc-2859	109	68	%	%	NOUN
dpc-2859	109	69	)	)	PUNCT
dpc-2859	109	70	58	58	NUM
dpc-2859	109	71	(	(	PUNCT
dpc-2859	109	72	27.6	27.6	NUM
dpc-2859	109	73	%	%	NOUN
dpc-2859	109	74	)	)	PUNCT
dpc-2859	109	75	56	56	NUM
dpc-2859	109	76	(	(	PUNCT
dpc-2859	109	77	26.6	26.6	NUM
dpc-2859	109	78	%	%	NOUN
dpc-2859	109	79	)	)	PUNCT
dpc-2859	109	80	39	39	NUM
dpc-2859	109	81	(	(	PUNCT
dpc-2859	109	82	18.5	18.5	NUM
dpc-2859	109	83	%	%	NOUN
dpc-2859	109	84	)	)	PUNCT
dpc-2859	109	85	36	36	NUM
dpc-2859	109	86	(	(	PUNCT
dpc-2859	109	87	17.1	17.1	NUM
dpc-2859	109	88	%	%	NOUN
dpc-2859	109	89	)	)	PUNCT
dpc-2859	109	90	36	36	NUM
dpc-2859	109	91	(	(	PUNCT
dpc-2859	109	92	17.1	17.1	NUM
dpc-2859	109	93	%	%	NOUN
dpc-2859	109	94	)	)	PUNCT
dpc-2859	109	95	30	30	NUM
dpc-2859	109	96	(	(	PUNCT
dpc-2859	109	97	14.2	14.2	NUM
dpc-2859	109	98	%	%	NOUN
dpc-2859	109	99	)	)	PUNCT
dpc-2859	109	100	21	21	NUM
dpc-2859	109	101	(	(	PUNCT
dpc-2859	109	102	10	10	NUM
dpc-2859	109	103	%	%	NOUN
dpc-2859	109	104	)	)	PUNCT
dpc-2859	109	105	18	18	NUM
dpc-2859	109	106	(	(	PUNCT
dpc-2859	109	107	8.6	8.6	NUM
dpc-2859	109	108	%	%	NOUN
dpc-2859	109	109	)	)	PUNCT
dpc-2859	109	110	18	18	NUM
dpc-2859	109	111	(	(	PUNCT
dpc-2859	109	112	8.6	8.6	NUM
dpc-2859	109	113	%	%	NOUN
dpc-2859	109	114	)	)	PUNCT
dpc-2859	109	115	17	17	NUM
dpc-2859	109	116	(	(	PUNCT
dpc-2859	109	117	8.1	8.1	NUM
dpc-2859	109	118	%	%	NOUN
dpc-2859	109	119	)	)	PUNCT
dpc-2859	109	120	15	15	NUM
dpc-2859	109	121	(	(	PUNCT
dpc-2859	109	122	7.1	7.1	NUM
dpc-2859	109	123	%	%	NOUN
dpc-2859	109	124	)	)	PUNCT
dpc-2859	109	125	9	9	NUM
dpc-2859	109	126	(	(	PUNCT
dpc-2859	109	127	4.2	4.2	NUM
dpc-2859	109	128	%	%	NOUN
dpc-2859	109	129	)	)	PUNCT
dpc-2859	109	130	8	8	NUM
dpc-2859	109	131	(	(	PUNCT
dpc-2859	109	132	3.8	3.8	NUM
dpc-2859	109	133	%	%	NOUN
dpc-2859	109	134	)	)	PUNCT
dpc-2859	109	135	7	7	NUM
dpc-2859	109	136	(	(	PUNCT
dpc-2859	109	137	3.3	3.3	NUM
dpc-2859	109	138	%	%	NOUN
dpc-2859	109	139	)	)	PUNCT
dpc-2859	109	140	2	2	NUM
dpc-2859	109	141	(	(	PUNCT
dpc-2859	109	142	1	1	NUM
dpc-2859	109	143	%	%	NOUN
dpc-2859	109	144	)	)	PUNCT
dpc-2859	109	145	0	0	NUM
dpc-2859	110	1	(	(	PUNCT
dpc-2859	110	2	0	0	NUM
dpc-2859	110	3	%	%	NOUN
dpc-2859	110	4	)	)	PUNCT
dpc-2859	110	5	4	4	NUM
dpc-2859	110	6	original	original	ADJ
dpc-2859	110	7	article	article	NOUN
dpc-2859	110	8	|	|	ADV
dpc-2859	110	9	dermatol	dermatol	ADJ
dpc-2859	110	10	pract	pract	NOUN
dpc-2859	110	11	concept	concept	NOUN
dpc-2859	110	12	.	.	PUNCT
dpc-2859	111	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	111	2	develop	develop	VERB
dpc-2859	111	3	accordingly	accordingly	ADV
dpc-2859	111	4	can	can	AUX
dpc-2859	111	5	be	be	AUX
dpc-2859	111	6	prevented	prevent	VERB
dpc-2859	111	7	.	.	PUNCT
dpc-2859	112	1	however	however	ADV
dpc-2859	112	2	,	,	PUNCT
dpc-2859	112	3	further	further	ADJ
dpc-2859	112	4	case	case	NOUN
dpc-2859	112	5	-	-	PUNCT
dpc-2859	112	6	controlled	control	VERB
dpc-2859	112	7	studies	study	NOUN
dpc-2859	112	8	with	with	ADP
dpc-2859	112	9	low	low	ADJ
dpc-2859	112	10	dose	dose	NOUN
dpc-2859	112	11	or	or	CCONJ
dpc-2859	112	12	fixed	fix	VERB
dpc-2859	112	13	-	-	PUNCT
dpc-2859	112	14	dose	dose	NOUN
dpc-2859	112	15	are	be	AUX
dpc-2859	112	16	needed	need	VERB
dpc-2859	112	17	in	in	ADP
dpc-2859	112	18	order	order	NOUN
dpc-2859	112	19	to	to	PART
dpc-2859	112	20	clarify	clarify	VERB
dpc-2859	112	21	the	the	DET
dpc-2859	112	22	relationship	relationship	NOUN
dpc-2859	112	23	between	between	ADP
dpc-2859	112	24	systemic	systemic	ADJ
dpc-2859	112	25	isotretinoin	isotretinoin	PROPN
dpc-2859	112	26	therapy	therapy	NOUN
dpc-2859	112	27	and	and	CCONJ
dpc-2859	112	28	anal	anal	ADJ
dpc-2859	112	29	mucosal	mucosal	NOUN
dpc-2859	112	30	dryness	dryness	NOUN
dpc-2859	112	31	,	,	PUNCT
dpc-2859	112	32	constipation	constipation	NOUN
dpc-2859	112	33	,	,	PUNCT
dpc-2859	112	34	anal	anal	ADJ
dpc-2859	112	35	fissure	fissure	NOUN
dpc-2859	112	36	,	,	PUNCT
dpc-2859	112	37	and	and	CCONJ
dpc-2859	112	38	rectal	rectal	ADJ
dpc-2859	112	39	bleeding	bleeding	NOUN
dpc-2859	112	40	.	.	PUNCT
dpc-2859	113	1	references	reference	NOUN
dpc-2859	113	2	1	1	NUM
dpc-2859	113	3	.	.	PUNCT
dpc-2859	113	4	zaenglein	zaenglein	PROPN
dpc-2859	113	5	al	al	PROPN
dpc-2859	113	6	,	,	PUNCT
dpc-2859	113	7	thiboutot	thiboutot	NOUN
dpc-2859	113	8	dm	dm	PROPN
dpc-2859	113	9	.	.	PUNCT
dpc-2859	113	10	acne	acne	PROPN
dpc-2859	113	11	vulgaris	vulgaris	NOUN
dpc-2859	113	12	.	.	PUNCT
dpc-2859	114	1	in	in	ADP
dpc-2859	114	2	bolognia	bolognia	PROPN
dpc-2859	114	3	jl	jl	PROPN
dpc-2859	114	4	,	,	PUNCT
dpc-2859	114	5	jorizza	jorizza	PROPN
dpc-2859	114	6	jl	jl	PROPN
dpc-2859	114	7	,	,	PUNCT
dpc-2859	114	8	rapini	rapini	NOUN
dpc-2859	114	9	rp	rp	NOUN
dpc-2859	114	10	,	,	PUNCT
dpc-2859	114	11	editors	editor	NOUN
dpc-2859	114	12	.	.	PUNCT
dpc-2859	115	1	dermatology	dermatology	NOUN
dpc-2859	115	2	.	.	PUNCT
dpc-2859	116	1	2nd	2nd	ADJ
dpc-2859	116	2	ed	ed	NOUN
dpc-2859	116	3	.	.	PUNCT
dpc-2859	117	1	spain	spain	PROPN
dpc-2859	117	2	,	,	PUNCT
dpc-2859	117	3	mosby	mosby	PROPN
dpc-2859	117	4	elsevier	elsevier	PROPN
dpc-2859	117	5	inc	inc	PROPN
dpc-2859	117	6	2008:495	2008:495	PROPN
dpc-2859	117	7	-	-	PUNCT
dpc-2859	117	8	508	508	NUM
dpc-2859	117	9	.	.	NOUN
dpc-2859	118	1	2	2	NUM
dpc-2859	118	2	.	.	X
dpc-2859	118	3	rapp	rapp	PROPN
dpc-2859	118	4	da	da	PROPN
dpc-2859	118	5	,	,	PUNCT
dpc-2859	118	6	brenes	brenes	PROPN
dpc-2859	118	7	ga	ga	PROPN
dpc-2859	118	8	,	,	PUNCT
dpc-2859	118	9	feldman	feldman	PROPN
dpc-2859	118	10	sr	sr	PROPN
dpc-2859	118	11	,	,	PUNCT
dpc-2859	118	12	et	et	PROPN
dpc-2859	118	13	al	al	PROPN
dpc-2859	118	14	.	.	PROPN
dpc-2859	118	15	anger	anger	NOUN
dpc-2859	118	16	and	and	CCONJ
dpc-2859	118	17	acne	acne	NOUN
dpc-2859	118	18	:	:	PUNCT
dpc-2859	118	19	implications	implication	NOUN
dpc-2859	118	20	for	for	ADP
dpc-2859	118	21	quality	quality	NOUN
dpc-2859	118	22	of	of	ADP
dpc-2859	118	23	life	life	NOUN
dpc-2859	118	24	,	,	PUNCT
dpc-2859	118	25	patient	patient	ADJ
dpc-2859	118	26	satisfaction	satisfaction	NOUN
dpc-2859	118	27	and	and	CCONJ
dpc-2859	118	28	clinical	clinical	ADJ
dpc-2859	118	29	care	care	NOUN
dpc-2859	118	30	.	.	PUNCT
dpc-2859	119	1	br	br	PROPN
dpc-2859	119	2	j	j	PROPN
dpc-2859	119	3	dermatol	dermatol	NOUN
dpc-2859	119	4	.	.	PUNCT
dpc-2859	120	1	2004;151(1):183	2004;151(1):183	NUM
dpc-2859	120	2	-	-	SYM
dpc-2859	120	3	189	189	NUM
dpc-2859	120	4	.	.	PUNCT
dpc-2859	120	5	doi	doi	NOUN
dpc-2859	120	6	:	:	PUNCT
dpc-2859	120	7	10.1111	10.1111	NUM
dpc-2859	120	8	/	/	SYM
dpc-2859	120	9	j.1365	j.1365	NOUN
dpc-2859	120	10	-2133.2004.06078.x	-2133.2004.06078.x	NOUN
dpc-2859	120	11	.	.	PUNCT
dpc-2859	121	1	pmid	pmid	NOUN
dpc-2859	121	2	:	:	PUNCT
dpc-2859	121	3	15270889	15270889	NUM
dpc-2859	121	4	.	.	PUNCT
dpc-2859	122	1	3	3	X
dpc-2859	122	2	.	.	X
dpc-2859	122	3	tom	tom	PROPN
dpc-2859	122	4	wl	wl	PROPN
dpc-2859	122	5	,	,	PUNCT
dpc-2859	122	6	friedlander	friedlander	PROPN
dpc-2859	122	7	sf	sf	PROPN
dpc-2859	122	8	.	.	PUNCT
dpc-2859	122	9	acne	acne	PROPN
dpc-2859	122	10	through	through	ADP
dpc-2859	122	11	the	the	DET
dpc-2859	122	12	ages	age	NOUN
dpc-2859	122	13	:	:	PUNCT
dpc-2859	122	14	case	case	NOUN
dpc-2859	122	15	-	-	PUNCT
dpc-2859	122	16	based	base	VERB
dpc-2859	122	17	observations	observation	NOUN
dpc-2859	122	18	through	through	ADP
dpc-2859	122	19	childhood	childhood	NOUN
dpc-2859	122	20	and	and	CCONJ
dpc-2859	122	21	adolescence	adolescence	NOUN
dpc-2859	122	22	.	.	PUNCT
dpc-2859	123	1	clin	clin	PROPN
dpc-2859	123	2	pediatr	pediatr	PROPN
dpc-2859	123	3	(	(	PUNCT
dpc-2859	123	4	phila	phila	PROPN
dpc-2859	123	5	)	)	PUNCT
dpc-2859	123	6	.	.	PUNCT
dpc-2859	124	1	2008;47(7):639	2008;47(7):639	NUM
dpc-2859	124	2	-	-	SYM
dpc-2859	124	3	651	651	NUM
dpc-2859	124	4	.	.	PUNCT
dpc-2859	125	1	doi	doi	NOUN
dpc-2859	125	2	:	:	PUNCT
dpc-2859	125	3	10.1177/0009922808315444	10.1177/0009922808315444	NUM
dpc-2859	125	4	.	.	PUNCT
dpc-2859	126	1	pmid	pmid	NOUN
dpc-2859	126	2	:	:	PUNCT
dpc-2859	126	3	18698096	18698096	NUM
dpc-2859	126	4	.	.	PUNCT
dpc-2859	127	1	4	4	X
dpc-2859	127	2	.	.	X
dpc-2859	127	3	zanglein	zanglein	PROPN
dpc-2859	127	4	al	al	PROPN
dpc-2859	127	5	,	,	PUNCT
dpc-2859	127	6	graber	graber	PROPN
dpc-2859	127	7	me	i	PRON
dpc-2859	127	8	,	,	PUNCT
dpc-2859	127	9	thiboutot	thiboutot	NOUN
dpc-2859	127	10	dm	dm	PROPN
dpc-2859	127	11	,	,	PUNCT
dpc-2859	127	12	strauss	strauss	PROPN
dpc-2859	127	13	js	js	PROPN
dpc-2859	127	14	.	.	PUNCT
dpc-2859	128	1	acne	acne	PROPN
dpc-2859	128	2	vulgaris	vulgaris	NOUN
dpc-2859	128	3	and	and	CCONJ
dpc-2859	128	4	acneiform	acneiform	NOUN
dpc-2859	128	5	eruptions	eruption	NOUN
dpc-2859	128	6	.	.	PUNCT
dpc-2859	129	1	in	in	ADP
dpc-2859	129	2	wolff	wolff	PROPN
dpc-2859	129	3	k	k	PROPN
dpc-2859	129	4	,	,	PUNCT
dpc-2859	129	5	goldsmith	goldsmith	PROPN
dpc-2859	129	6	la	la	PROPN
dpc-2859	129	7	,	,	PUNCT
dpc-2859	129	8	katz	katz	PROPN
dpc-2859	129	9	si	si	PROPN
dpc-2859	129	10	,	,	PUNCT
dpc-2859	129	11	gilchrest	gilchr	ADJ
dpc-2859	129	12	ba	ba	NOUN
dpc-2859	129	13	,	,	PUNCT
dpc-2859	129	14	paller	paller	NOUN
dpc-2859	129	15	as	as	ADP
dpc-2859	129	16	,	,	PUNCT
dpc-2859	129	17	leffell	leffell	PROPN
dpc-2859	129	18	dj	dj	NOUN
dpc-2859	129	19	,	,	PUNCT
dpc-2859	129	20	editors	editor	NOUN
dpc-2859	129	21	.	.	PUNCT
dpc-2859	130	1	fitzpatrick	fitzpatrick	PROPN
dpc-2859	130	2	’s	’s	PART
dpc-2859	130	3	dermatology	dermatology	NOUN
dpc-2859	130	4	in	in	ADP
dpc-2859	130	5	general	general	ADJ
dpc-2859	130	6	medicine	medicine	NOUN
dpc-2859	130	7	.	.	PUNCT
dpc-2859	131	1	7th	7th	ADJ
dpc-2859	131	2	ed	ed	NOUN
dpc-2859	131	3	.	.	PUNCT
dpc-2859	132	1	new	new	PROPN
dpc-2859	132	2	york	york	PROPN
dpc-2859	132	3	,	,	PUNCT
dpc-2859	132	4	mcgraw	mcgraw	PROPN
dpc-2859	132	5	hill	hill	PROPN
dpc-2859	132	6	.	.	PUNCT
dpc-2859	133	1	inc	inc	PROPN
dpc-2859	133	2	2008:690	2008:690	PROPN
dpc-2859	133	3	-	-	SYM
dpc-2859	133	4	703	703	NUM
dpc-2859	133	5	.	.	NOUN
dpc-2859	133	6	5	5	NUM
dpc-2859	133	7	.	.	X
dpc-2859	133	8	olutunmbi	olutunmbi	PROPN
dpc-2859	133	9	y	y	PROPN
dpc-2859	133	10	,	,	PUNCT
dpc-2859	133	11	paley	paley	PROPN
dpc-2859	133	12	k	k	PROPN
dpc-2859	133	13	,	,	PUNCT
dpc-2859	133	14	english	english	PROPN
dpc-2859	133	15	jc	jc	PROPN
dpc-2859	133	16	3rd	3rd	PROPN
dpc-2859	133	17	.	.	PUNCT
dpc-2859	134	1	adolescent	adolescent	ADJ
dpc-2859	134	2	female	female	ADJ
dpc-2859	134	3	acne	acne	NOUN
dpc-2859	134	4	:	:	PUNCT
dpc-2859	134	5	etiology	etiology	NOUN
dpc-2859	134	6	and	and	CCONJ
dpc-2859	134	7	management	management	NOUN
dpc-2859	134	8	.	.	PUNCT
dpc-2859	135	1	j	j	PROPN
dpc-2859	135	2	pediatr	pediatr	PROPN
dpc-2859	135	3	adolesc	adolesc	PROPN
dpc-2859	135	4	gynecol	gynecol	PROPN
dpc-2859	135	5	.	.	PUNCT
dpc-2859	136	1	2008;;21(4):171	2008;;21(4):171	NOUN
dpc-2859	137	1	-	-	NOUN
dpc-2859	137	2	176	176	NUM
dpc-2859	137	3	.	.	PUNCT
dpc-2859	138	1	doi	doi	NOUN
dpc-2859	138	2	:	:	PUNCT
dpc-2859	138	3	10.1016	10.1016	NUM
dpc-2859	138	4	/	/	SYM
dpc-2859	138	5	j.jpag.2007.07.004	j.jpag.2007.07.004	PROPN
dpc-2859	138	6	.	.	PUNCT
dpc-2859	139	1	pmid	pmid	NOUN
dpc-2859	139	2	:	:	PUNCT
dpc-2859	139	3	18656070	18656070	NUM
dpc-2859	139	4	.	.	PUNCT
dpc-2859	140	1	6	6	X
dpc-2859	140	2	.	.	X
dpc-2859	141	1	rigopoulos	rigopoulos	PROPN
dpc-2859	141	2	d	d	PROPN
dpc-2859	141	3	,	,	PUNCT
dpc-2859	141	4	larios	larios	PROPN
dpc-2859	141	5	g	g	PROPN
dpc-2859	141	6	,	,	PUNCT
dpc-2859	141	7	katsambas	katsambas	PROPN
dpc-2859	141	8	ad	ad	NOUN
dpc-2859	141	9	:	:	PUNCT
dpc-2859	141	10	the	the	DET
dpc-2859	141	11	role	role	NOUN
dpc-2859	141	12	of	of	ADP
dpc-2859	141	13	isotretinoin	isotretinoin	PROPN
dpc-2859	141	14	in	in	ADP
dpc-2859	141	15	acne	acne	NOUN
dpc-2859	141	16	therapy	therapy	NOUN
dpc-2859	141	17	:	:	PUNCT
dpc-2859	141	18	why	why	SCONJ
dpc-2859	141	19	not	not	PART
dpc-2859	141	20	as	as	ADP
dpc-2859	141	21	first	first	ADJ
dpc-2859	141	22	-	-	PUNCT
dpc-2859	141	23	line	line	NOUN
dpc-2859	141	24	therapy	therapy	NOUN
dpc-2859	141	25	?	?	PUNCT
dpc-2859	142	1	facts	fact	NOUN
dpc-2859	142	2	and	and	CCONJ
dpc-2859	142	3	controversies	controversy	NOUN
dpc-2859	142	4	.	.	PUNCT
dpc-2859	143	1	clin	clin	PROPN
dpc-2859	143	2	dermatol.;28(1):24	dermatol.;28(1):24	PROPN
dpc-2859	143	3	-	-	PUNCT
dpc-2859	143	4	30	30	NUM
dpc-2859	143	5	.	.	PUNCT
dpc-2859	144	1	doi	doi	NOUN
dpc-2859	144	2	:	:	PUNCT
dpc-2859	144	3	10.1016	10.1016	NUM
dpc-2859	144	4	/	/	SYM
dpc-2859	144	5	j.clindermatol.2009.03.005	j.clindermatol.2009.03.005	PROPN
dpc-2859	144	6	.	.	PUNCT
dpc-2859	144	7	pmid	pmid	NOUN
dpc-2859	144	8	:	:	PUNCT
dpc-2859	144	9	20082946	20082946	NUM
dpc-2859	144	10	.	.	PUNCT
dpc-2859	145	1	7	7	X
dpc-2859	145	2	.	.	NUM
dpc-2859	145	3	hodgkiss	hodgkis	VERB
dpc-2859	145	4	-	-	PUNCT
dpc-2859	145	5	harlow	harlow	PROPN
dpc-2859	145	6	cj	cj	PROPN
dpc-2859	145	7	,	,	PUNCT
dpc-2859	145	8	eichenfield	eichenfield	VERB
dpc-2859	145	9	lf	lf	PROPN
dpc-2859	145	10	,	,	PUNCT
dpc-2859	145	11	dohil	dohil	PROPN
dpc-2859	145	12	ma	ma	PROPN
dpc-2859	145	13	.	.	PROPN
dpc-2859	145	14	effective	effective	ADJ
dpc-2859	145	15	monitoring	monitoring	NOUN
dpc-2859	145	16	of	of	ADP
dpc-2859	145	17	isotretinoin	isotretinoin	PROPN
dpc-2859	145	18	safety	safety	NOUN
dpc-2859	145	19	in	in	ADP
dpc-2859	145	20	a	a	DET
dpc-2859	145	21	pediatric	pediatric	ADJ
dpc-2859	145	22	dermatology	dermatology	NOUN
dpc-2859	145	23	population	population	NOUN
dpc-2859	145	24	:	:	PUNCT
dpc-2859	145	25	a	a	DET
dpc-2859	145	26	novel	novel	ADJ
dpc-2859	145	27	“	"	PUNCT
dpc-2859	145	28	patient	patient	ADJ
dpc-2859	145	29	symptom	symptom	NOUN
dpc-2859	145	30	survey	survey	NOUN
dpc-2859	145	31	”	"	PUNCT
dpc-2859	145	32	approach	approach	NOUN
dpc-2859	145	33	.	.	PUNCT
dpc-2859	146	1	j	j	PROPN
dpc-2859	146	2	am	be	AUX
dpc-2859	146	3	acad	acad	ADJ
dpc-2859	146	4	dermatol	dermatol	NOUN
dpc-2859	146	5	.	.	PUNCT
dpc-2859	147	1	2011	2011	NUM
dpc-2859	147	2	;	;	PUNCT
dpc-2859	148	1	65(3):517	65(3):517	NOUN
dpc-2859	148	2	-	-	SYM
dpc-2859	148	3	524	524	NUM
dpc-2859	148	4	.	.	PUNCT
dpc-2859	149	1	doi	doi	NOUN
dpc-2859	149	2	:	:	PUNCT
dpc-2859	149	3	10.1016	10.1016	NUM
dpc-2859	149	4	/	/	SYM
dpc-2859	149	5	j	j	PROPN
dpc-2859	149	6	.jaad.2010.06.040	.jaad.2010.06.040	PUNCT
dpc-2859	149	7	.	.	PUNCT
dpc-2859	150	1	pmid	pmid	NOUN
dpc-2859	150	2	:	:	PUNCT
dpc-2859	150	3	21632153	21632153	NUM
dpc-2859	150	4	.	.	PUNCT
dpc-2859	151	1	pmcid	pmcid	NOUN
dpc-2859	151	2	:	:	PUNCT
dpc-2859	151	3	pmc4336191	pmc4336191	NOUN
dpc-2859	151	4	.	.	PUNCT
dpc-2859	152	1	8	8	X
dpc-2859	152	2	.	.	X
dpc-2859	152	3	lowenstein	lowenstein	PROPN
dpc-2859	152	4	eb	eb	PROPN
dpc-2859	152	5	,	,	PUNCT
dpc-2859	152	6	lowenstein	lowenstein	PROPN
dpc-2859	152	7	ej	ej	PROPN
dpc-2859	152	8	:	:	PUNCT
dpc-2859	152	9	isotretinoin	isotretinoin	PROPN
dpc-2859	152	10	systemic	systemic	ADJ
dpc-2859	152	11	therapy	therapy	NOUN
dpc-2859	152	12	and	and	CCONJ
dpc-2859	152	13	the	the	DET
dpc-2859	152	14	shadow	shadow	NOUN
dpc-2859	152	15	cast	cast	VERB
dpc-2859	152	16	upon	upon	SCONJ
dpc-2859	152	17	dermatology	dermatology	NOUN
dpc-2859	152	18	’s	’s	PART
dpc-2859	152	19	downtrodden	downtrodden	ADJ
dpc-2859	152	20	hero	hero	NOUN
dpc-2859	152	21	.	.	PUNCT
dpc-2859	153	1	clin	clin	PROPN
dpc-2859	153	2	dermatol	dermatol	NOUN
dpc-2859	153	3	.	.	PUNCT
dpc-2859	154	1	2011	2011	NUM
dpc-2859	154	2	;	;	PUNCT
dpc-2859	154	3	29(6):652	29(6):652	NUM
dpc-2859	154	4	-	-	PUNCT
dpc-2859	154	5	661	661	NUM
dpc-2859	154	6	.	.	PUNCT
dpc-2859	155	1	doi	doi	NOUN
dpc-2859	155	2	:	:	PUNCT
dpc-2859	155	3	10.1016	10.1016	NUM
dpc-2859	155	4	/	/	SYM
dpc-2859	155	5	j.clindermatol	j.clindermatol	VERB
dpc-2859	155	6	.2011.08.026	.2011.08.026	PROPN
dpc-2859	155	7	.	.	PUNCT
dpc-2859	156	1	pmid	pmid	NOUN
dpc-2859	156	2	:	:	PUNCT
dpc-2859	156	3	22014987	22014987	NUM
dpc-2859	156	4	.	.	PUNCT
dpc-2859	157	1	9	9	X
dpc-2859	157	2	.	.	X
dpc-2859	157	3	habeshian	habeshian	PROPN
dpc-2859	157	4	ka	ka	PROPN
dpc-2859	157	5	,	,	PUNCT
dpc-2859	157	6	cohen	cohen	PROPN
dpc-2859	157	7	ba	ba	PROPN
dpc-2859	157	8	.	.	PUNCT
dpc-2859	158	1	current	current	ADJ
dpc-2859	158	2	issues	issue	NOUN
dpc-2859	158	3	in	in	ADP
dpc-2859	158	4	the	the	DET
dpc-2859	158	5	treatment	treatment	NOUN
dpc-2859	158	6	of	of	ADP
dpc-2859	158	7	acne	acne	NOUN
dpc-2859	158	8	vulgaris	vulgaris	NOUN
dpc-2859	158	9	.	.	PUNCT
dpc-2859	159	1	pediatrics	pediatric	NOUN
dpc-2859	159	2	.	.	PUNCT
dpc-2859	160	1	2020;145(suppl	2020;145(suppl	NUM
dpc-2859	160	2	2):s225	2):s225	NUM
dpc-2859	160	3	-	-	SYM
dpc-2859	160	4	s230	s230	PROPN
dpc-2859	160	5	.	.	PUNCT
dpc-2859	161	1	doi	doi	NOUN
dpc-2859	161	2	:	:	PUNCT
dpc-2859	161	3	10.1542	10.1542	NUM
dpc-2859	161	4	/	/	SYM
dpc-2859	161	5	peds.2019	peds.2019	PROPN
dpc-2859	161	6	-	-	PUNCT
dpc-2859	161	7	2056l	2056l	NUM
dpc-2859	161	8	.	.	PUNCT
dpc-2859	162	1	pmid	pmid	NOUN
dpc-2859	162	2	:	:	PUNCT
dpc-2859	162	3	32358215	32358215	NUM
dpc-2859	162	4	.	.	PUNCT
dpc-2859	163	1	10	10	NUM
dpc-2859	163	2	.	.	PUNCT
dpc-2859	164	1	cunliffe	cunliffe	PROPN
dpc-2859	164	2	wj	wj	PROPN
dpc-2859	164	3	,	,	PUNCT
dpc-2859	164	4	van	van	PROPN
dpc-2859	164	5	de	de	X
dpc-2859	164	6	kerkhof	kerkhof	PROPN
dpc-2859	164	7	pc	pc	NOUN
dpc-2859	164	8	,	,	PUNCT
dpc-2859	164	9	caputo	caputo	PROPN
dpc-2859	164	10	r	r	PROPN
dpc-2859	164	11	,	,	PUNCT
dpc-2859	164	12	et	et	PROPN
dpc-2859	164	13	al	al	PROPN
dpc-2859	164	14	.	.	PUNCT
dpc-2859	165	1	roaccutane	roaccutane	PROPN
dpc-2859	165	2	treatment	treatment	NOUN
dpc-2859	165	3	guidelines	guideline	NOUN
dpc-2859	165	4	:	:	PUNCT
dpc-2859	165	5	results	result	NOUN
dpc-2859	165	6	of	of	ADP
dpc-2859	165	7	an	an	DET
dpc-2859	165	8	international	international	ADJ
dpc-2859	165	9	survey	survey	NOUN
dpc-2859	165	10	.	.	PUNCT
dpc-2859	166	1	dermatology	dermatology	NOUN
dpc-2859	166	2	.	.	PUNCT
dpc-2859	167	1	1997;194(4):351	1997;194(4):351	NUM
dpc-2859	167	2	-	-	SYM
dpc-2859	167	3	357	357	NUM
dpc-2859	167	4	.	.	PUNCT
dpc-2859	168	1	doi	doi	NOUN
dpc-2859	168	2	:	:	PUNCT
dpc-2859	168	3	10.1159/000246134	10.1159/000246134	NUM
dpc-2859	168	4	.	.	PUNCT
dpc-2859	169	1	pmid	pmid	NOUN
dpc-2859	169	2	:	:	PUNCT
dpc-2859	169	3	9252756	9252756	NUM
dpc-2859	169	4	.	.	PUNCT
dpc-2859	170	1	11	11	NUM
dpc-2859	170	2	.	.	X
dpc-2859	171	1	borovaya	borovaya	PROPN
dpc-2859	171	2	,	,	PUNCT
dpc-2859	171	3	a	a	PRON
dpc-2859	171	4	,	,	PUNCT
dpc-2859	171	5	dombrowski	dombrowski	PROPN
dpc-2859	171	6	y	y	NOUN
dpc-2859	171	7	,	,	PUNCT
dpc-2859	171	8	zwicker	zwicker	PROPN
dpc-2859	171	9	s	s	PROPN
dpc-2859	171	10	,	,	PUNCT
dpc-2859	171	11	et	et	PROPN
dpc-2859	171	12	al	al	PROPN
dpc-2859	171	13	.	.	PUNCT
dpc-2859	171	14	isotretinoin	isotretinoin	PROPN
dpc-2859	171	15	therapy	therapy	NOUN
dpc-2859	171	16	changes	change	VERB
dpc-2859	171	17	the	the	DET
dpc-2859	171	18	expression	expression	NOUN
dpc-2859	171	19	of	of	ADP
dpc-2859	171	20	antimicrobial	antimicrobial	ADJ
dpc-2859	171	21	peptides	peptide	NOUN
dpc-2859	171	22	in	in	ADP
dpc-2859	171	23	acne	acne	NOUN
dpc-2859	171	24	vulgaris	vulgaris	NOUN
dpc-2859	171	25	.	.	PUNCT
dpc-2859	172	1	archives	archive	NOUN
dpc-2859	172	2	of	of	ADP
dpc-2859	172	3	dermatological	dermatological	ADJ
dpc-2859	172	4	research	research	NOUN
dpc-2859	172	5	.	.	PUNCT
dpc-2859	173	1	2014;306(8):689	2014;306(8):689	NUM
dpc-2859	173	2	-	-	SYM
dpc-2859	173	3	700	700	NUM
dpc-2859	173	4	.	.	PUNCT
dpc-2859	174	1	doi	doi	NOUN
dpc-2859	174	2	:	:	PUNCT
dpc-2859	174	3	10.1007	10.1007	NUM
dpc-2859	174	4	/	/	SYM
dpc-2859	174	5	s00403	s00403	NOUN
dpc-2859	174	6	-	-	PUNCT
dpc-2859	174	7	014	014	NUM
dpc-2859	174	8	-	-	PUNCT
dpc-2859	174	9	1477	1477	NUM
dpc-2859	174	10	-	-	SYM
dpc-2859	174	11	3	3	NUM
dpc-2859	174	12	.	.	PUNCT
dpc-2859	175	1	pmid	pmid	NOUN
dpc-2859	175	2	:	:	PUNCT
dpc-2859	175	3	24916439	24916439	NUM
dpc-2859	175	4	.	.	PUNCT
dpc-2859	176	1	12	12	NUM
dpc-2859	176	2	.	.	PUNCT
dpc-2859	177	1	li	li	PROPN
dpc-2859	177	2	w	w	PROPN
dpc-2859	177	3	,	,	PUNCT
dpc-2859	177	4	liu	liu	PROPN
dpc-2859	177	5	y	y	PROPN
dpc-2859	177	6	,	,	PUNCT
dpc-2859	177	7	luo	luo	PROPN
dpc-2859	177	8	q	q	PROPN
dpc-2859	177	9	,	,	PUNCT
dpc-2859	177	10	li	li	PROPN
dpc-2859	177	11	x	x	PROPN
dpc-2859	177	12	-	-	PROPN
dpc-2859	177	13	m	m	PROPN
dpc-2859	177	14	,	,	PUNCT
dpc-2859	177	15	zhang	zhang	PROPN
dpc-2859	177	16	x	x	PROPN
dpc-2859	177	17	-	-	PROPN
dpc-2859	177	18	b.	b.	PROPN
dpc-2859	177	19	off	off	ADP
dpc-2859	177	20	-	-	PUNCT
dpc-2859	177	21	label	label	NOUN
dpc-2859	177	22	uses	use	NOUN
dpc-2859	177	23	of	of	ADP
dpc-2859	177	24	retinoids	retinoid	NOUN
dpc-2859	177	25	in	in	ADP
dpc-2859	177	26	dermatology	dermatology	NOUN
dpc-2859	177	27	.	.	PUNCT
dpc-2859	178	1	our	our	PRON
dpc-2859	178	2	dermatol	dermatol	NOUN
dpc-2859	178	3	online	online	ADV
dpc-2859	178	4	.	.	PUNCT
dpc-2859	179	1	2012;3(suppl	2012;3(suppl	X
dpc-2859	179	2	.	.	PUNCT
dpc-2859	179	3	 	 	SPACE
dpc-2859	179	4	1	1	NUM
dpc-2859	179	5	):	):	PUNCT
dpc-2859	179	6	259	259	NUM
dpc-2859	179	7	-	-	SYM
dpc-2859	179	8	278	278	NUM
dpc-2859	179	9	.	.	PUNCT
dpc-2859	180	1	doi	doi	NOUN
dpc-2859	180	2	:	:	PUNCT
dpc-2859	180	3	10.7241	10.7241	NUM
dpc-2859	180	4	/	/	SYM
dpc-2859	180	5	ourd.20124.62	ourd.20124.62	ADJ
dpc-2859	180	6	.	.	PUNCT
dpc-2859	181	1	13	13	NUM
dpc-2859	181	2	.	.	PUNCT
dpc-2859	182	1	martin	martin	PROPN
dpc-2859	182	2	p	p	PROPN
dpc-2859	182	3	,	,	PUNCT
dpc-2859	182	4	manley	manley	PROPN
dpc-2859	182	5	pn	pn	PROPN
dpc-2859	182	6	,	,	PUNCT
dpc-2859	182	7	depew	depew	PROPN
dpc-2859	182	8	wt	wt	PROPN
dpc-2859	182	9	,	,	PUNCT
dpc-2859	182	10	blakeman	blakeman	PROPN
dpc-2859	182	11	jm	jm	PROPN
dpc-2859	182	12	.	.	PROPN
dpc-2859	182	13	isotretinoin	isotretinoin	PROPN
dpc-2859	182	14	-	-	PUNCT
dpc-2859	182	15	associated	associate	VERB
dpc-2859	182	16	proctosigmoiditis	proctosigmoiditis	PROPN
dpc-2859	182	17	.	.	PUNCT
dpc-2859	183	1	gastroenterology	gastroenterology	NOUN
dpc-2859	183	2	.	.	PUNCT
dpc-2859	184	1	1987;93(3):606	1987;93(3):606	NUM
dpc-2859	184	2	-	-	PUNCT
dpc-2859	184	3	609	609	NUM
dpc-2859	184	4	.	.	PUNCT
dpc-2859	185	1	doi	doi	NOUN
dpc-2859	185	2	:	:	PUNCT
dpc-2859	185	3	10.1016/0016	10.1016/0016	NUM
dpc-2859	185	4	-	-	SYM
dpc-2859	185	5	5085(87)90925	5085(87)90925	NUM
dpc-2859	185	6	-	-	PUNCT
dpc-2859	185	7	5	5	NUM
dpc-2859	185	8	.	.	PUNCT
dpc-2859	186	1	pmid:3475230	pmid:3475230	PROPN
dpc-2859	186	2	.	.	PUNCT
dpc-2859	187	1	isotretinoin	isotretinoin	PROPN
dpc-2859	187	2	can	can	AUX
dpc-2859	187	3	affect	affect	VERB
dpc-2859	187	4	the	the	DET
dpc-2859	187	5	anal	anal	ADJ
dpc-2859	187	6	mucosa	mucosa	NOUN
dpc-2859	187	7	,	,	PUNCT
dpc-2859	187	8	and	and	CCONJ
dpc-2859	187	9	this	this	PRON
dpc-2859	187	10	can	can	AUX
dpc-2859	187	11	promote	promote	VERB
dpc-2859	187	12	mucous	mucous	ADJ
dpc-2859	187	13	dryness	dryness	NOUN
dpc-2859	187	14	,	,	PUNCT
dpc-2859	187	15	leading	lead	VERB
dpc-2859	187	16	to	to	ADP
dpc-2859	187	17	mucosal	mucosal	NOUN
dpc-2859	187	18	erosion	erosion	NOUN
dpc-2859	187	19	and	and	CCONJ
dpc-2859	187	20	fissure	fissure	VERB
dpc-2859	187	21	formation	formation	NOUN
dpc-2859	187	22	.	.	PUNCT
dpc-2859	188	1	anal	anal	ADJ
dpc-2859	188	2	fissure	fissure	NOUN
dpc-2859	188	3	is	be	AUX
dpc-2859	188	4	a	a	DET
dpc-2859	188	5	tear	tear	NOUN
dpc-2859	188	6	in	in	ADP
dpc-2859	188	7	the	the	DET
dpc-2859	188	8	anoderm	anoderm	NOUN
dpc-2859	188	9	distal	distal	NOUN
dpc-2859	188	10	to	to	ADP
dpc-2859	188	11	the	the	DET
dpc-2859	188	12	dentate	dentate	ADJ
dpc-2859	188	13	line	line	NOUN
dpc-2859	188	14	.	.	PUNCT
dpc-2859	189	1	the	the	DET
dpc-2859	189	2	diagnosis	diagnosis	NOUN
dpc-2859	189	3	of	of	ADP
dpc-2859	189	4	an	an	DET
dpc-2859	189	5	anal	anal	ADJ
dpc-2859	189	6	fissure	fissure	NOUN
dpc-2859	189	7	is	be	AUX
dpc-2859	189	8	made	make	VERB
dpc-2859	189	9	with	with	ADP
dpc-2859	189	10	the	the	DET
dpc-2859	189	11	evaluation	evaluation	NOUN
dpc-2859	189	12	of	of	ADP
dpc-2859	189	13	the	the	DET
dpc-2859	189	14	medical	medical	ADJ
dpc-2859	189	15	history	history	NOUN
dpc-2859	189	16	,	,	PUNCT
dpc-2859	189	17	preferably	preferably	ADV
dpc-2859	189	18	on	on	ADP
dpc-2859	189	19	the	the	DET
dpc-2859	189	20	proctology	proctology	NOUN
dpc-2859	189	21	table	table	NOUN
dpc-2859	189	22	,	,	PUNCT
dpc-2859	189	23	and	and	CCONJ
dpc-2859	189	24	basically	basically	ADV
dpc-2859	189	25	through	through	ADP
dpc-2859	189	26	inspection	inspection	NOUN
dpc-2859	189	27	.	.	PUNCT
dpc-2859	190	1	with	with	ADP
dpc-2859	190	2	a	a	DET
dpc-2859	190	3	thorough	thorough	ADJ
dpc-2859	190	4	assessment	assessment	NOUN
dpc-2859	190	5	of	of	ADP
dpc-2859	190	6	pain	pain	NOUN
dpc-2859	190	7	in	in	ADP
dpc-2859	190	8	the	the	DET
dpc-2859	190	9	anal	anal	ADJ
dpc-2859	190	10	fissure	fissure	NOUN
dpc-2859	190	11	,	,	PUNCT
dpc-2859	190	12	diagnosis	diagnosis	NOUN
dpc-2859	190	13	can	can	AUX
dpc-2859	190	14	be	be	AUX
dpc-2859	190	15	made	make	VERB
dpc-2859	190	16	with	with	ADP
dpc-2859	190	17	approximately	approximately	ADV
dpc-2859	190	18	100	100	NUM
dpc-2859	190	19	%	%	NOUN
dpc-2859	190	20	accuracy	accuracy	NOUN
dpc-2859	190	21	as	as	ADV
dpc-2859	190	22	early	early	ADV
dpc-2859	190	23	as	as	ADP
dpc-2859	190	24	at	at	ADP
dpc-2859	190	25	the	the	DET
dpc-2859	190	26	stage	stage	NOUN
dpc-2859	190	27	of	of	ADP
dpc-2859	190	28	taking	take	VERB
dpc-2859	190	29	a	a	DET
dpc-2859	190	30	medical	medical	ADJ
dpc-2859	190	31	history	history	NOUN
dpc-2859	190	32	[	[	X
dpc-2859	190	33	33	33	NUM
dpc-2859	190	34	]	]	PUNCT
dpc-2859	190	35	.	.	PUNCT
dpc-2859	191	1	one	one	NUM
dpc-2859	191	2	of	of	ADP
dpc-2859	191	3	the	the	DET
dpc-2859	191	4	most	most	ADV
dpc-2859	191	5	popular	popular	ADJ
dpc-2859	191	6	theories	theory	NOUN
dpc-2859	191	7	about	about	ADP
dpc-2859	191	8	anal	anal	ADJ
dpc-2859	191	9	fissure	fissure	NOUN
dpc-2859	191	10	is	be	AUX
dpc-2859	191	11	that	that	PRON
dpc-2859	191	12	mucosal	mucosal	NOUN
dpc-2859	191	13	rupture	rupture	NOUN
dpc-2859	191	14	and	and	CCONJ
dpc-2859	191	15	anal	anal	ADJ
dpc-2859	191	16	fissure	fissure	NOUN
dpc-2859	191	17	develop	develop	VERB
dpc-2859	191	18	after	after	SCONJ
dpc-2859	191	19	anal	anal	ADJ
dpc-2859	191	20	canal	canal	NOUN
dpc-2859	191	21	trauma	trauma	VERB
dpc-2859	191	22	secondary	secondary	ADJ
dpc-2859	191	23	to	to	ADP
dpc-2859	191	24	constipation	constipation	NOUN
dpc-2859	191	25	and	and	CCONJ
dpc-2859	191	26	hard	hard	ADJ
dpc-2859	191	27	stools	stool	NOUN
dpc-2859	191	28	.	.	PUNCT
dpc-2859	192	1	in	in	ADP
dpc-2859	192	2	addition	addition	NOUN
dpc-2859	192	3	,	,	PUNCT
dpc-2859	192	4	in	in	ADP
dpc-2859	192	5	patients	patient	NOUN
dpc-2859	192	6	with	with	ADP
dpc-2859	192	7	xerosis	xerosis	NOUN
dpc-2859	192	8	of	of	ADP
dpc-2859	192	9	the	the	DET
dpc-2859	192	10	anal	anal	ADJ
dpc-2859	192	11	mucosa	mucosa	NOUN
dpc-2859	192	12	,	,	PUNCT
dpc-2859	192	13	hard	hard	ADJ
dpc-2859	192	14	stools	stool	NOUN
dpc-2859	192	15	due	due	ADJ
dpc-2859	192	16	to	to	ADP
dpc-2859	192	17	constipation	constipation	NOUN
dpc-2859	192	18	may	may	AUX
dpc-2859	192	19	traumatize	traumatize	VERB
dpc-2859	192	20	the	the	DET
dpc-2859	192	21	mucosa	mucosa	NOUN
dpc-2859	192	22	during	during	ADP
dpc-2859	192	23	the	the	DET
dpc-2859	192	24	passage	passage	NOUN
dpc-2859	192	25	,	,	PUNCT
dpc-2859	192	26	causing	cause	VERB
dpc-2859	192	27	fissure	fissure	NOUN
dpc-2859	192	28	and	and	CCONJ
dpc-2859	192	29	pain	pain	NOUN
dpc-2859	192	30	and	and	CCONJ
dpc-2859	192	31	bleeding	bleeding	NOUN
dpc-2859	192	32	as	as	ADP
dpc-2859	192	33	a	a	DET
dpc-2859	192	34	result	result	NOUN
dpc-2859	192	35	[	[	X
dpc-2859	192	36	34,35	34,35	NOUN
dpc-2859	192	37	]	]	X
dpc-2859	192	38	.	.	PUNCT
dpc-2859	193	1	several	several	ADJ
dpc-2859	193	2	cases	case	NOUN
dpc-2859	193	3	of	of	ADP
dpc-2859	193	4	isotretinoin	isotretinoin	PROPN
dpc-2859	193	5	-	-	PUNCT
dpc-2859	193	6	related	relate	VERB
dpc-2859	193	7	anal	anal	ADJ
dpc-2859	193	8	fissure	fissure	NOUN
dpc-2859	193	9	and	and	CCONJ
dpc-2859	193	10	rectal	rectal	ADJ
dpc-2859	193	11	bleeding	bleeding	NOUN
dpc-2859	193	12	have	have	AUX
dpc-2859	193	13	been	be	AUX
dpc-2859	193	14	reported	report	VERB
dpc-2859	193	15	in	in	ADP
dpc-2859	193	16	the	the	DET
dpc-2859	193	17	literature	literature	NOUN
dpc-2859	194	1	[	[	X
dpc-2859	194	2	36,37	36,37	X
dpc-2859	194	3	]	]	X
dpc-2859	194	4	.	.	PUNCT
dpc-2859	195	1	in	in	ADP
dpc-2859	195	2	a	a	DET
dpc-2859	195	3	study	study	NOUN
dpc-2859	195	4	from	from	ADP
dpc-2859	195	5	our	our	PRON
dpc-2859	195	6	country	country	NOUN
dpc-2859	195	7	,	,	PUNCT
dpc-2859	195	8	gastrointestinal	gastrointestinal	ADJ
dpc-2859	195	9	side	side	NOUN
dpc-2859	195	10	effects	effect	NOUN
dpc-2859	195	11	were	be	AUX
dpc-2859	195	12	detected	detect	VERB
dpc-2859	195	13	in	in	ADP
dpc-2859	195	14	four	four	NUM
dpc-2859	195	15	patients	patient	NOUN
dpc-2859	195	16	(	(	PUNCT
dpc-2859	195	17	2.6	2.6	NUM
dpc-2859	195	18	%	%	NOUN
dpc-2859	195	19	)	)	PUNCT
dpc-2859	196	1	[	[	X
dpc-2859	196	2	38	38	NUM
dpc-2859	196	3	]	]	PUNCT
dpc-2859	196	4	.	.	PUNCT
dpc-2859	197	1	in	in	ADP
dpc-2859	197	2	1	1	NUM
dpc-2859	197	3	of	of	ADP
dpc-2859	197	4	these	these	PRON
dpc-2859	197	5	,	,	PUNCT
dpc-2859	197	6	anal	anal	ADJ
dpc-2859	197	7	fissure	fissure	NOUN
dpc-2859	197	8	developed	develop	VERB
dpc-2859	197	9	in	in	ADP
dpc-2859	197	10	the	the	DET
dpc-2859	197	11	first	first	ADJ
dpc-2859	197	12	month	month	NOUN
dpc-2859	197	13	of	of	ADP
dpc-2859	197	14	the	the	DET
dpc-2859	197	15	treatment	treatment	NOUN
dpc-2859	197	16	,	,	PUNCT
dpc-2859	197	17	rectal	rectal	ADJ
dpc-2859	197	18	bleeding	bleeding	NOUN
dpc-2859	197	19	in	in	ADP
dpc-2859	197	20	the	the	DET
dpc-2859	197	21	third	third	ADJ
dpc-2859	197	22	month	month	NOUN
dpc-2859	197	23	of	of	ADP
dpc-2859	197	24	treatment	treatment	NOUN
dpc-2859	197	25	in	in	ADP
dpc-2859	197	26	2	2	NUM
dpc-2859	197	27	patients	patient	NOUN
dpc-2859	197	28	,	,	PUNCT
dpc-2859	197	29	and	and	CCONJ
dpc-2859	197	30	constipation	constipation	NOUN
dpc-2859	197	31	in	in	ADP
dpc-2859	197	32	the	the	DET
dpc-2859	197	33	fourth	fourth	ADJ
dpc-2859	197	34	month	month	NOUN
dpc-2859	197	35	of	of	ADP
dpc-2859	197	36	treatment	treatment	NOUN
dpc-2859	197	37	in	in	ADP
dpc-2859	197	38	1	1	NUM
dpc-2859	197	39	patient	patient	NOUN
dpc-2859	197	40	.	.	PUNCT
dpc-2859	198	1	other	other	ADJ
dpc-2859	198	2	than	than	ADP
dpc-2859	198	3	these	these	PRON
dpc-2859	198	4	,	,	PUNCT
dpc-2859	198	5	several	several	ADJ
dpc-2859	198	6	other	other	ADJ
dpc-2859	198	7	cases	case	NOUN
dpc-2859	198	8	with	with	ADP
dpc-2859	198	9	isotretinoin	isotretinoin	PROPN
dpc-2859	198	10	-	-	PUNCT
dpc-2859	198	11	related	relate	VERB
dpc-2859	198	12	anal	anal	ADJ
dpc-2859	198	13	fissures	fissure	NOUN
dpc-2859	198	14	and	and	CCONJ
dpc-2859	198	15	rectal	rectal	ADJ
dpc-2859	198	16	bleeding	bleeding	NOUN
dpc-2859	198	17	have	have	AUX
dpc-2859	198	18	been	be	AUX
dpc-2859	198	19	reported	report	VERB
dpc-2859	198	20	in	in	ADP
dpc-2859	198	21	the	the	DET
dpc-2859	198	22	literature	literature	NOUN
dpc-2859	199	1	[	[	X
dpc-2859	199	2	15,36,37	15,36,37	X
dpc-2859	199	3	]	]	PUNCT
dpc-2859	199	4	.	.	PUNCT
dpc-2859	200	1	again	again	ADV
dpc-2859	200	2	,	,	PUNCT
dpc-2859	200	3	in	in	ADP
dpc-2859	200	4	different	different	ADJ
dpc-2859	200	5	studies	study	NOUN
dpc-2859	200	6	from	from	ADP
dpc-2859	200	7	our	our	PRON
dpc-2859	200	8	country	country	NOUN
dpc-2859	200	9	and	and	CCONJ
dpc-2859	200	10	abroad	abroad	ADV
dpc-2859	200	11	[	[	X
dpc-2859	200	12	19,21,39	19,21,39	NOUN
dpc-2859	200	13	]	]	PUNCT
dpc-2859	200	14	,	,	PUNCT
dpc-2859	200	15	gis	gis	PROPN
dpc-2859	200	16	side	side	NOUN
dpc-2859	200	17	effects	effect	NOUN
dpc-2859	200	18	were	be	AUX
dpc-2859	200	19	found	find	VERB
dpc-2859	200	20	to	to	PART
dpc-2859	200	21	be	be	AUX
dpc-2859	200	22	between	between	ADP
dpc-2859	200	23	0.19%-0.3	0.19%-0.3	NOUN
dpc-2859	200	24	%	%	NOUN
dpc-2859	200	25	.	.	PUNCT
dpc-2859	201	1	however	however	ADV
dpc-2859	201	2	,	,	PUNCT
dpc-2859	201	3	it	it	PRON
dpc-2859	201	4	has	have	AUX
dpc-2859	201	5	not	not	PART
dpc-2859	201	6	been	be	AUX
dpc-2859	201	7	reported	report	VERB
dpc-2859	201	8	in	in	ADP
dpc-2859	201	9	detail	detail	NOUN
dpc-2859	201	10	whether	whether	SCONJ
dpc-2859	201	11	these	these	DET
dpc-2859	201	12	side	side	NOUN
dpc-2859	201	13	effects	effect	NOUN
dpc-2859	201	14	are	be	AUX
dpc-2859	201	15	ibd	ibd	NOUN
dpc-2859	201	16	or	or	CCONJ
dpc-2859	201	17	anal	anal	ADJ
dpc-2859	201	18	fissures	fissure	NOUN
dpc-2859	201	19	.	.	PUNCT
dpc-2859	202	1	in	in	ADP
dpc-2859	202	2	our	our	PRON
dpc-2859	202	3	study	study	NOUN
dpc-2859	202	4	,	,	PUNCT
dpc-2859	202	5	the	the	DET
dpc-2859	202	6	number	number	NOUN
dpc-2859	202	7	of	of	ADP
dpc-2859	202	8	patients	patient	NOUN
dpc-2859	202	9	with	with	ADP
dpc-2859	202	10	constipation	constipation	NOUN
dpc-2859	202	11	was	be	AUX
dpc-2859	202	12	36	36	NUM
dpc-2859	202	13	.	.	PUNCT
dpc-2859	203	1	anal	anal	ADJ
dpc-2859	203	2	fissures	fissure	NOUN
dpc-2859	203	3	were	be	AUX
dpc-2859	203	4	detected	detect	VERB
dpc-2859	203	5	in	in	ADP
dpc-2859	203	6	7	7	NUM
dpc-2859	203	7	patients	patient	NOUN
dpc-2859	203	8	with	with	ADP
dpc-2859	203	9	constipation	constipation	NOUN
dpc-2859	203	10	.	.	PUNCT
dpc-2859	204	1	anal	anal	ADJ
dpc-2859	204	2	bleeding	bleeding	NOUN
dpc-2859	204	3	was	be	AUX
dpc-2859	204	4	another	another	DET
dpc-2859	204	5	accompanying	accompanying	ADJ
dpc-2859	204	6	finding	finding	NOUN
dpc-2859	204	7	in	in	ADP
dpc-2859	204	8	all	all	DET
dpc-2859	204	9	patients	patient	NOUN
dpc-2859	204	10	with	with	ADP
dpc-2859	204	11	fissure	fissure	NOUN
dpc-2859	204	12	.	.	PUNCT
dpc-2859	205	1	however	however	ADV
dpc-2859	205	2	,	,	PUNCT
dpc-2859	205	3	constipation	constipation	NOUN
dpc-2859	205	4	was	be	AUX
dpc-2859	205	5	detected	detect	VERB
dpc-2859	205	6	in	in	ADP
dpc-2859	205	7	only	only	ADV
dpc-2859	205	8	2	2	NUM
dpc-2859	205	9	of	of	ADP
dpc-2859	205	10	10	10	NUM
dpc-2859	205	11	patients	patient	NOUN
dpc-2859	205	12	with	with	ADP
dpc-2859	205	13	mucosal	mucosal	ADJ
dpc-2859	205	14	erosion	erosion	NOUN
dpc-2859	205	15	.	.	PUNCT
dpc-2859	206	1	this	this	PRON
dpc-2859	206	2	was	be	AUX
dpc-2859	206	3	a	a	DET
dpc-2859	206	4	condition	condition	NOUN
dpc-2859	206	5	that	that	PRON
dpc-2859	206	6	supported	support	VERB
dpc-2859	206	7	isotretinoin	isotretinoin	PROPN
dpc-2859	206	8	causing	cause	VERB
dpc-2859	206	9	dryness	dryness	NOUN
dpc-2859	206	10	in	in	ADP
dpc-2859	206	11	the	the	DET
dpc-2859	206	12	anal	anal	ADJ
dpc-2859	206	13	mucosa	mucosa	NOUN
dpc-2859	206	14	.	.	PUNCT
dpc-2859	207	1	medical	medical	ADJ
dpc-2859	207	2	treatment	treatment	NOUN
dpc-2859	207	3	and	and	CCONJ
dpc-2859	207	4	topical	topical	ADJ
dpc-2859	207	5	moisturizer	moisturizer	NOUN
dpc-2859	207	6	were	be	AUX
dpc-2859	207	7	recommended	recommend	VERB
dpc-2859	207	8	by	by	ADP
dpc-2859	207	9	general	general	ADJ
dpc-2859	207	10	surgery	surgery	NOUN
dpc-2859	207	11	clinic	clinic	NOUN
dpc-2859	207	12	to	to	ADP
dpc-2859	207	13	patients	patient	NOUN
dpc-2859	207	14	complaining	complain	VERB
dpc-2859	207	15	with	with	ADP
dpc-2859	207	16	fissure	fissure	NOUN
dpc-2859	207	17	,	,	PUNCT
dpc-2859	207	18	rectal	rectal	ADJ
dpc-2859	207	19	bleeding	bleeding	NOUN
dpc-2859	207	20	and	and	CCONJ
dpc-2859	207	21	constipation	constipation	NOUN
dpc-2859	207	22	.	.	PUNCT
dpc-2859	208	1	in	in	ADP
dpc-2859	208	2	addition	addition	NOUN
dpc-2859	208	3	,	,	PUNCT
dpc-2859	208	4	the	the	DET
dpc-2859	208	5	dose	dose	NOUN
dpc-2859	208	6	of	of	ADP
dpc-2859	208	7	isotretinoin	isotretinoin	PROPN
dpc-2859	208	8	was	be	AUX
dpc-2859	208	9	reduced	reduce	VERB
dpc-2859	208	10	in	in	ADP
dpc-2859	208	11	3	3	NUM
dpc-2859	208	12	patients	patient	NOUN
dpc-2859	208	13	.	.	PUNCT
dpc-2859	209	1	after	after	ADP
dpc-2859	209	2	treatment	treatment	NOUN
dpc-2859	209	3	,	,	PUNCT
dpc-2859	209	4	there	there	PRON
dpc-2859	209	5	was	be	VERB
dpc-2859	209	6	an	an	DET
dpc-2859	209	7	improvement	improvement	NOUN
dpc-2859	209	8	in	in	ADP
dpc-2859	209	9	complaints	complaint	NOUN
dpc-2859	209	10	in	in	ADP
dpc-2859	209	11	patients	patient	NOUN
dpc-2859	209	12	except	except	SCONJ
dpc-2859	209	13	for	for	ADP
dpc-2859	209	14	1	1	NUM
dpc-2859	209	15	patient	patient	NOUN
dpc-2859	209	16	.	.	PUNCT
dpc-2859	210	1	in	in	ADP
dpc-2859	210	2	conclusion	conclusion	NOUN
dpc-2859	210	3	,	,	PUNCT
dpc-2859	210	4	frequent	frequent	ADJ
dpc-2859	210	5	mucosal	mucosal	NOUN
dpc-2859	210	6	dryness	dryness	NOUN
dpc-2859	210	7	in	in	ADP
dpc-2859	210	8	patients	patient	NOUN
dpc-2859	210	9	using	use	VERB
dpc-2859	210	10	systemic	systemic	ADJ
dpc-2859	210	11	isotretinoin	isotretinoin	PROPN
dpc-2859	210	12	due	due	ADP
dpc-2859	210	13	to	to	ADP
dpc-2859	210	14	severe	severe	ADJ
dpc-2859	210	15	acne	acne	NOUN
dpc-2859	210	16	may	may	AUX
dpc-2859	210	17	also	also	ADV
dpc-2859	210	18	be	be	AUX
dpc-2859	210	19	encountered	encounter	VERB
dpc-2859	210	20	in	in	ADP
dpc-2859	210	21	the	the	DET
dpc-2859	210	22	anal	anal	ADJ
dpc-2859	210	23	mucosa	mucosa	NOUN
dpc-2859	210	24	.	.	PUNCT
dpc-2859	211	1	therefore	therefore	ADV
dpc-2859	211	2	,	,	PUNCT
dpc-2859	211	3	in	in	ADP
dpc-2859	211	4	addition	addition	NOUN
dpc-2859	211	5	to	to	ADP
dpc-2859	211	6	starting	start	VERB
dpc-2859	211	7	moisturizer	moisturizer	NOUN
dpc-2859	211	8	to	to	PART
dpc-2859	211	9	prevent	prevent	VERB
dpc-2859	211	10	cheilitis	cheilitis	NOUN
dpc-2859	211	11	,	,	PUNCT
dpc-2859	211	12	dry	dry	ADJ
dpc-2859	211	13	eye	eye	NOUN
dpc-2859	211	14	and	and	CCONJ
dpc-2859	211	15	epistaxis	epistaxis	ADJ
dpc-2859	211	16	in	in	ADP
dpc-2859	211	17	patients	patient	NOUN
dpc-2859	211	18	with	with	ADP
dpc-2859	211	19	whom	whom	PRON
dpc-2859	211	20	we	we	PRON
dpc-2859	211	21	started	start	VERB
dpc-2859	211	22	isotretinoin	isotretinoin	PROPN
dpc-2859	211	23	treatment	treatment	NOUN
dpc-2859	211	24	,	,	PUNCT
dpc-2859	211	25	topical	topical	ADJ
dpc-2859	211	26	moisturizers	moisturizer	NOUN
dpc-2859	211	27	can	can	AUX
dpc-2859	211	28	also	also	ADV
dpc-2859	211	29	be	be	AUX
dpc-2859	211	30	added	add	VERB
dpc-2859	211	31	to	to	ADP
dpc-2859	211	32	the	the	DET
dpc-2859	211	33	treatment	treatment	NOUN
dpc-2859	211	34	of	of	ADP
dpc-2859	211	35	anal	anal	ADJ
dpc-2859	211	36	area	area	NOUN
dpc-2859	211	37	dryness	dryness	NOUN
dpc-2859	211	38	and	and	CCONJ
dpc-2859	211	39	an	an	DET
dpc-2859	211	40	appropriate	appropriate	ADJ
dpc-2859	211	41	diet	diet	NOUN
dpc-2859	211	42	can	can	AUX
dpc-2859	211	43	be	be	AUX
dpc-2859	211	44	recommended	recommend	VERB
dpc-2859	211	45	.	.	PUNCT
dpc-2859	212	1	presence	presence	NOUN
dpc-2859	212	2	of	of	ADP
dpc-2859	212	3	constipation	constipation	NOUN
dpc-2859	212	4	and	and	CCONJ
dpc-2859	212	5	rectal	rectal	ADJ
dpc-2859	212	6	bleeding	bleeding	NOUN
dpc-2859	212	7	should	should	AUX
dpc-2859	212	8	be	be	AUX
dpc-2859	212	9	investigated	investigate	VERB
dpc-2859	212	10	during	during	ADP
dpc-2859	212	11	patient	patient	ADJ
dpc-2859	212	12	controls	control	NOUN
dpc-2859	212	13	.	.	PUNCT
dpc-2859	213	1	in	in	ADP
dpc-2859	213	2	the	the	DET
dpc-2859	213	3	case	case	NOUN
dpc-2859	213	4	of	of	ADP
dpc-2859	213	5	their	their	PRON
dpc-2859	213	6	presence	presence	NOUN
dpc-2859	213	7	,	,	PUNCT
dpc-2859	213	8	treatment	treatment	NOUN
dpc-2859	213	9	should	should	AUX
dpc-2859	213	10	be	be	AUX
dpc-2859	213	11	arranged	arrange	VERB
dpc-2859	213	12	by	by	ADP
dpc-2859	213	13	the	the	DET
dpc-2859	213	14	relevant	relevant	ADJ
dpc-2859	213	15	clinics	clinic	NOUN
dpc-2859	213	16	.	.	PUNCT
dpc-2859	214	1	thus	thus	ADV
dpc-2859	214	2	,	,	PUNCT
dpc-2859	214	3	possible	possible	ADJ
dpc-2859	214	4	fissure	fissure	NOUN
dpc-2859	214	5	and	and	CCONJ
dpc-2859	214	6	severe	severe	ADJ
dpc-2859	214	7	mucosal	mucosal	NOUN
dpc-2859	214	8	erosion	erosion	NOUN
dpc-2859	214	9	and	and	CCONJ
dpc-2859	214	10	subsequent	subsequent	ADJ
dpc-2859	214	11	rectal	rectal	ADJ
dpc-2859	214	12	bleeding	bleeding	NOUN
dpc-2859	214	13	that	that	PRON
dpc-2859	214	14	may	may	AUX
dpc-2859	214	15	original	original	ADJ
dpc-2859	214	16	article	article	NOUN
dpc-2859	214	17	|	|	ADV
dpc-2859	214	18	dermatol	dermatol	ADJ
dpc-2859	214	19	pract	pract	NOUN
dpc-2859	214	20	concept	concept	NOUN
dpc-2859	214	21	.	.	PUNCT
dpc-2859	215	1	2023;13(3):e2023133	2023;13(3):e2023133	NUM
dpc-2859	215	2	5	5	NUM
dpc-2859	215	3	28	28	NUM
dpc-2859	215	4	.	.	PUNCT
dpc-2859	216	1	alhusayen	alhusayen	PROPN
dpc-2859	216	2	ro	ro	NOUN
dpc-2859	216	3	,	,	PUNCT
dpc-2859	216	4	juurlink	juurlink	NOUN
dpc-2859	216	5	dn	dn	PROPN
dpc-2859	216	6	,	,	PUNCT
dpc-2859	216	7	mamdani	mamdani	PROPN
dpc-2859	216	8	mm	mm	PROPN
dpc-2859	216	9	,	,	PUNCT
dpc-2859	216	10	morrow	morrow	PROPN
dpc-2859	216	11	rl	rl	PROPN
dpc-2859	216	12	,	,	PUNCT
dpc-2859	216	13	shear	shear	PROPN
dpc-2859	216	14	nh	nh	PROPN
dpc-2859	216	15	,	,	PUNCT
dpc-2859	216	16	dormuth	dormuth	PROPN
dpc-2859	216	17	cr	cr	PROPN
dpc-2859	216	18	.	.	PUNCT
dpc-2859	217	1	isotretinoin	isotretinoin	PROPN
dpc-2859	217	2	use	use	NOUN
dpc-2859	217	3	and	and	CCONJ
dpc-2859	217	4	the	the	DET
dpc-2859	217	5	risk	risk	NOUN
dpc-2859	217	6	of	of	ADP
dpc-2859	217	7	inflammatory	inflammatory	ADJ
dpc-2859	217	8	bowel	bowel	NOUN
dpc-2859	217	9	disease	disease	NOUN
dpc-2859	217	10	:	:	PUNCT
dpc-2859	217	11	a	a	DET
dpc-2859	217	12	population	population	NOUN
dpc-2859	217	13	-	-	PUNCT
dpc-2859	217	14	based	base	VERB
dpc-2859	217	15	cohort	cohort	NOUN
dpc-2859	217	16	study	study	NOUN
dpc-2859	217	17	.	.	PUNCT
dpc-2859	218	1	j	j	PROPN
dpc-2859	218	2	invest	invest	VERB
dpc-2859	218	3	dermatol	dermatol	NOUN
dpc-2859	218	4	.	.	PUNCT
dpc-2859	219	1	2013	2013	NUM
dpc-2859	219	2	;	;	PUNCT
dpc-2859	219	3	133(4):907	133(4):907	NUM
dpc-2859	219	4	-	-	SYM
dpc-2859	219	5	912	912	NUM
dpc-2859	219	6	.	.	PUNCT
dpc-2859	220	1	doi	doi	NOUN
dpc-2859	220	2	:	:	PUNCT
dpc-2859	220	3	10.1038	10.1038	NUM
dpc-2859	220	4	/	/	SYM
dpc-2859	220	5	jid.2012.387	jid.2012.387	PROPN
dpc-2859	220	6	.	.	PUNCT
dpc-2859	221	1	pmid	pmid	NOUN
dpc-2859	221	2	:	:	PUNCT
dpc-2859	221	3	23096714	23096714	NUM
dpc-2859	221	4	.	.	PUNCT
dpc-2859	222	1	pmcid	pmcid	NOUN
dpc-2859	222	2	:	:	PUNCT
dpc-2859	222	3	pmc3728031	pmc3728031	NOUN
dpc-2859	222	4	.	.	PUNCT
dpc-2859	223	1	29	29	NUM
dpc-2859	223	2	.	.	X
dpc-2859	223	3	etminan	etminan	NUM
dpc-2859	223	4	m	m	PROPN
dpc-2859	223	5	,	,	PUNCT
dpc-2859	223	6	bird	bird	PROPN
dpc-2859	223	7	st	st	PROPN
dpc-2859	223	8	,	,	PUNCT
dpc-2859	223	9	delaney	delaney	PROPN
dpc-2859	223	10	ja	ja	PROPN
dpc-2859	223	11	,	,	PUNCT
dpc-2859	223	12	bressler	bressler	PROPN
dpc-2859	223	13	b	b	PROPN
dpc-2859	223	14	,	,	PUNCT
dpc-2859	223	15	brophy	brophy	PROPN
dpc-2859	223	16	jm	jm	PROPN
dpc-2859	223	17	.	.	PROPN
dpc-2859	223	18	isotretinoin	isotretinoin	PROPN
dpc-2859	223	19	and	and	CCONJ
dpc-2859	223	20	risk	risk	NOUN
dpc-2859	223	21	for	for	ADP
dpc-2859	223	22	inflammatory	inflammatory	ADJ
dpc-2859	223	23	bowel	bowel	NOUN
dpc-2859	223	24	disease	disease	NOUN
dpc-2859	223	25	:	:	PUNCT
dpc-2859	223	26	a	a	DET
dpc-2859	223	27	nested	nested	ADJ
dpc-2859	223	28	case	case	NOUN
dpc-2859	223	29	-	-	PUNCT
dpc-2859	223	30	control	control	NOUN
dpc-2859	223	31	study	study	NOUN
dpc-2859	223	32	and	and	CCONJ
dpc-2859	223	33	meta	meta	NOUN
dpc-2859	223	34	-	-	PUNCT
dpc-2859	223	35	analysis	analysis	NOUN
dpc-2859	223	36	of	of	ADP
dpc-2859	223	37	published	publish	VERB
dpc-2859	223	38	and	and	CCONJ
dpc-2859	223	39	unpublished	unpublished	ADJ
dpc-2859	223	40	data	datum	NOUN
dpc-2859	223	41	.	.	PUNCT
dpc-2859	224	1	jama	jama	PROPN
dpc-2859	224	2	dermatol	dermatol	NOUN
dpc-2859	224	3	.	.	PUNCT
dpc-2859	225	1	2013;149(2):216	2013;149(2):216	NUM
dpc-2859	225	2	-	-	SYM
dpc-2859	225	3	220	220	NUM
dpc-2859	225	4	.	.	PUNCT
dpc-2859	225	5	doi	doi	NOUN
dpc-2859	225	6	:	:	PUNCT
dpc-2859	225	7	10.1001	10.1001	NUM
dpc-2859	225	8	/	/	SYM
dpc-2859	225	9	jamadermatol.2013.1344	jamadermatol.2013.1344	NOUN
dpc-2859	225	10	.	.	PUNCT
dpc-2859	226	1	pmid	pmid	NOUN
dpc-2859	226	2	:	:	PUNCT
dpc-2859	226	3	23426479	23426479	NUM
dpc-2859	226	4	.	.	PUNCT
dpc-2859	227	1	30	30	NUM
dpc-2859	227	2	.	.	PUNCT
dpc-2859	228	1	rashtak	rashtak	PROPN
dpc-2859	228	2	s	s	PROPN
dpc-2859	228	3	,	,	PUNCT
dpc-2859	228	4	khaleghi	khaleghi	PROPN
dpc-2859	228	5	s	s	PROPN
dpc-2859	228	6	,	,	PUNCT
dpc-2859	228	7	pittelkow	pittelkow	PROPN
dpc-2859	228	8	mr	mr	PROPN
dpc-2859	228	9	,	,	PUNCT
dpc-2859	228	10	larson	larson	PROPN
dpc-2859	228	11	jj	jj	PROPN
dpc-2859	228	12	,	,	PUNCT
dpc-2859	228	13	lahr	lahr	PROPN
dpc-2859	228	14	bd	bd	PROPN
dpc-2859	228	15	,	,	PUNCT
dpc-2859	228	16	murray	murray	PROPN
dpc-2859	228	17	ja	ja	PROPN
dpc-2859	228	18	.	.	PUNCT
dpc-2859	229	1	isotretinoin	isotretinoin	PROPN
dpc-2859	229	2	exposure	exposure	NOUN
dpc-2859	229	3	and	and	CCONJ
dpc-2859	229	4	risk	risk	NOUN
dpc-2859	229	5	of	of	ADP
dpc-2859	229	6	inflammatory	inflammatory	ADJ
dpc-2859	229	7	bowel	bowel	NOUN
dpc-2859	229	8	disease	disease	NOUN
dpc-2859	229	9	.	.	PUNCT
dpc-2859	230	1	jama	jama	PROPN
dpc-2859	230	2	dermatol	dermatol	NOUN
dpc-2859	230	3	.	.	PUNCT
dpc-2859	231	1	2014;150(12):1322	2014;150(12):1322	PROPN
dpc-2859	231	2	-	-	SYM
dpc-2859	231	3	1326	1326	NUM
dpc-2859	231	4	.	.	PUNCT
dpc-2859	232	1	doi	doi	NOUN
dpc-2859	232	2	:	:	PUNCT
dpc-2859	232	3	10.1001	10.1001	NUM
dpc-2859	232	4	/	/	SYM
dpc-2859	232	5	jamadermatol.2014.1540	jamadermatol.2014.1540	PROPN
dpc-2859	232	6	.	.	PUNCT
dpc-2859	233	1	pmid	pmid	NOUN
dpc-2859	233	2	:	:	PUNCT
dpc-2859	233	3	25207875	25207875	NUM
dpc-2859	233	4	.	.	PUNCT
dpc-2859	234	1	31	31	NUM
dpc-2859	234	2	.	.	PUNCT
dpc-2859	235	1	bernstein	bernstein	PROPN
dpc-2859	235	2	cn	cn	PROPN
dpc-2859	235	3	,	,	PUNCT
dpc-2859	235	4	nugent	nugent	PROPN
dpc-2859	235	5	z	z	PROPN
dpc-2859	235	6	,	,	PUNCT
dpc-2859	235	7	longobardi	longobardi	PROPN
dpc-2859	235	8	t	t	PROPN
dpc-2859	235	9	,	,	PUNCT
dpc-2859	235	10	blanchard	blanchard	PROPN
dpc-2859	235	11	jf	jf	PROPN
dpc-2859	235	12	.	.	PUNCT
dpc-2859	236	1	isotretinoin	isotretinoin	PROPN
dpc-2859	236	2	is	be	AUX
dpc-2859	236	3	not	not	PART
dpc-2859	236	4	associated	associate	VERB
dpc-2859	236	5	with	with	ADP
dpc-2859	236	6	inflammatory	inflammatory	ADJ
dpc-2859	236	7	bowel	bowel	NOUN
dpc-2859	236	8	disease	disease	NOUN
dpc-2859	236	9	:	:	PUNCT
dpc-2859	236	10	a	a	DET
dpc-2859	236	11	population	population	NOUN
dpc-2859	236	12	-	-	PUNCT
dpc-2859	236	13	based	base	VERB
dpc-2859	236	14	case	case	NOUN
dpc-2859	236	15	-	-	PUNCT
dpc-2859	236	16	control	control	NOUN
dpc-2859	236	17	study	study	NOUN
dpc-2859	236	18	.	.	PUNCT
dpc-2859	237	1	am	be	AUX
dpc-2859	237	2	j	j	PROPN
dpc-2859	237	3	gastroenterol	gastroenterol	NOUN
dpc-2859	237	4	.	.	PUNCT
dpc-2859	238	1	2009;104(11):2774	2009;104(11):2774	X
dpc-2859	238	2	-	-	PUNCT
dpc-2859	238	3	2778	2778	NUM
dpc-2859	238	4	.	.	PUNCT
dpc-2859	239	1	doi	doi	NOUN
dpc-2859	239	2	:	:	PUNCT
dpc-2859	239	3	10.1038	10.1038	NUM
dpc-2859	239	4	/	/	SYM
dpc-2859	239	5	ajg.2009.417	ajg.2009.417	NOUN
dpc-2859	239	6	.	.	PUNCT
dpc-2859	240	1	pmid	pmid	NOUN
dpc-2859	240	2	:	:	PUNCT
dpc-2859	240	3	19623167	19623167	NUM
dpc-2859	240	4	.	.	PUNCT
dpc-2859	241	1	32	32	NUM
dpc-2859	241	2	.	.	PUNCT
dpc-2859	242	1	brito	brito	PROPN
dpc-2859	242	2	mde	mde	PROPN
dpc-2859	242	3	f	f	AUX
dpc-2859	242	4	,	,	PUNCT
dpc-2859	242	5	sant’anna	sant’anna	VERB
dpc-2859	242	6	ip	ip	PROPN
dpc-2859	242	7	,	,	PUNCT
dpc-2859	242	8	galindo	galindo	PROPN
dpc-2859	242	9	jc	jc	PROPN
dpc-2859	242	10	,	,	PUNCT
dpc-2859	242	11	rosendo	rosendo	PROPN
dpc-2859	242	12	lh	lh	PROPN
dpc-2859	242	13	,	,	PUNCT
dpc-2859	242	14	santos	santos	PROPN
dpc-2859	242	15	jb	jb	PROPN
dpc-2859	242	16	.	.	PUNCT
dpc-2859	243	1	evaluation	evaluation	NOUN
dpc-2859	243	2	of	of	ADP
dpc-2859	243	3	clinical	clinical	ADJ
dpc-2859	243	4	adverse	adverse	ADJ
dpc-2859	243	5	eff	eff	PROPN
dpc-2859	243	6	ects	ect	NOUN
dpc-2859	243	7	and	and	CCONJ
dpc-2859	243	8	laboratory	laboratory	NOUN
dpc-2859	243	9	alterations	alteration	NOUN
dpc-2859	243	10	in	in	ADP
dpc-2859	243	11	patients	patient	NOUN
dpc-2859	243	12	with	with	ADP
dpc-2859	243	13	acne	acne	NOUN
dpc-2859	243	14	vulgaris	vulgaris	NOUN
dpc-2859	243	15	treated	treat	VERB
dpc-2859	243	16	with	with	ADP
dpc-2859	243	17	oral	oral	ADJ
dpc-2859	243	18	isotretinoin	isotretinoin	PROPN
dpc-2859	243	19	.	.	PUNCT
dpc-2859	244	1	a	a	DET
dpc-2859	244	2	bras	bras	NOUN
dpc-2859	244	3	dermatol	dermatol	NOUN
dpc-2859	244	4	.	.	PUNCT
dpc-2859	245	1	2010;-85(3):331	2010;-85(3):331	NUM
dpc-2859	245	2	-	-	SYM
dpc-2859	245	3	337	337	NUM
dpc-2859	245	4	.	.	PUNCT
dpc-2859	246	1	doi	doi	NOUN
dpc-2859	246	2	:	:	PUNCT
dpc-2859	246	3	10.1590	10.1590	NUM
dpc-2859	246	4	/	/	SYM
dpc-2859	246	5	s0365	s0365	NOUN
dpc-2859	246	6	-05962010000300006	-05962010000300006	NOUN
dpc-2859	246	7	.	.	PUNCT
dpc-2859	247	1	pmid	pmid	NOUN
dpc-2859	247	2	:	:	PUNCT
dpc-2859	247	3	20676466	20676466	NUM
dpc-2859	247	4	.	.	PUNCT
dpc-2859	248	1	33	33	NUM
dpc-2859	248	2	.	.	PUNCT
dpc-2859	249	1	menteş	menteş	PROPN
dpc-2859	249	2	b	b	NUM
dpc-2859	249	3	,	,	PUNCT
dpc-2859	249	4	leventoğlu	leventoğlu	PROPN
dpc-2859	249	5	s.	s.	PROPN
dpc-2859	249	6	anal	anal	PROPN
dpc-2859	249	7	fissür	fissür	PROPN
dpc-2859	249	8	.	.	PUNCT
dpc-2859	250	1	in	in	ADP
dpc-2859	250	2	:	:	PUNCT
dpc-2859	250	3	menteş	menteş	PROPN
dpc-2859	250	4	b	b	NUM
dpc-2859	250	5	,	,	PUNCT
dpc-2859	250	6	leventoğlu	leventoğlu	VERB
dpc-2859	250	7	a	a	DET
dpc-2859	250	8	,	,	PUNCT
dpc-2859	250	9	eds	eds	PROPN
dpc-2859	250	10	.	.	PUNCT
dpc-2859	251	1	anorektal	anorektal	PROPN
dpc-2859	251	2	bölgenin	bölgenin	PROPN
dpc-2859	251	3	selim	selim	PROPN
dpc-2859	251	4	hastalıkları	hastalıkları	PROPN
dpc-2859	251	5	.	.	PUNCT
dpc-2859	252	1	i̇stanbul	i̇stanbul	ADV
dpc-2859	252	2	;	;	PUNCT
dpc-2859	252	3	türk	türk	PROPN
dpc-2859	252	4	kolon	kolon	PROPN
dpc-2859	252	5	ve	ve	PROPN
dpc-2859	252	6	rektum	rektum	NOUN
dpc-2859	252	7	cerrahisi	cerrahisi	VERB
dpc-2859	252	8	derneği	derneği	NOUN
dpc-2859	252	9	.	.	PUNCT
dpc-2859	253	1	2011:37	2011:37	NUM
dpc-2859	253	2	-	-	SYM
dpc-2859	253	3	53	53	NUM
dpc-2859	253	4	.	.	PUNCT
dpc-2859	254	1	34	34	NUM
dpc-2859	254	2	.	.	PUNCT
dpc-2859	255	1	schlichtemeier	schlichtemeier	PROPN
dpc-2859	255	2	s	s	PROPN
dpc-2859	255	3	,	,	PUNCT
dpc-2859	255	4	engel	engel	PROPN
dpc-2859	255	5	a.	a.	PROPN
dpc-2859	255	6	anal	anal	PROPN
dpc-2859	255	7	fissure	fissure	NOUN
dpc-2859	255	8	.	.	PUNCT
dpc-2859	256	1	aust	aust	PROPN
dpc-2859	256	2	prescr	prescr	PROPN
dpc-2859	256	3	.	.	PUNCT
dpc-2859	257	1	2016;39(1):14	2016;39(1):14	NUM
dpc-2859	257	2	-	-	SYM
dpc-2859	257	3	17	17	NUM
dpc-2859	258	1	.	.	PUNCT
dpc-2859	258	2	doi	doi	NOUN
dpc-2859	258	3	:	:	PUNCT
dpc-2859	258	4	10.18773	10.18773	NUM
dpc-2859	258	5	/	/	SYM
dpc-2859	258	6	austprescr.2016.007	austprescr.2016.007	PROPN
dpc-2859	258	7	.	.	PUNCT
dpc-2859	259	1	pmid	pmid	NOUN
dpc-2859	259	2	:	:	PUNCT
dpc-2859	259	3	27041801	27041801	NUM
dpc-2859	259	4	.	.	PUNCT
dpc-2859	260	1	pmcid	pmcid	NOUN
dpc-2859	260	2	:	:	PUNCT
dpc-2859	260	3	pmc4816871	pmc4816871	PROPN
dpc-2859	260	4	.	.	PUNCT
dpc-2859	261	1	35	35	NUM
dpc-2859	261	2	.	.	PUNCT
dpc-2859	262	1	kenny	kenny	PROPN
dpc-2859	262	2	se	se	PROPN
dpc-2859	262	3	,	,	PUNCT
dpc-2859	262	4	irvine	irvine	PROPN
dpc-2859	262	5	t	t	PROPN
dpc-2859	262	6	,	,	PUNCT
dpc-2859	262	7	driver	driver	NOUN
dpc-2859	262	8	cp	cp	PROPN
dpc-2859	262	9	,	,	PUNCT
dpc-2859	262	10	et	et	PROPN
dpc-2859	262	11	al	al	PROPN
dpc-2859	262	12	.	.	PROPN
dpc-2859	262	13	double	double	ADJ
dpc-2859	262	14	blind	blind	ADJ
dpc-2859	262	15	randomised	randomise	VERB
dpc-2859	262	16	controlled	control	VERB
dpc-2859	262	17	trial	trial	NOUN
dpc-2859	262	18	of	of	ADP
dpc-2859	262	19	topical	topical	ADJ
dpc-2859	262	20	glyceryl	glyceryl	NOUN
dpc-2859	262	21	trinitrate	trinitrate	NOUN
dpc-2859	262	22	in	in	ADP
dpc-2859	262	23	anal	anal	ADJ
dpc-2859	262	24	fissure	fissure	NOUN
dpc-2859	262	25	.	.	PUNCT
dpc-2859	263	1	arch	arch	ADJ
dpc-2859	263	2	dis	dis	PROPN
dpc-2859	263	3	child	child	NOUN
dpc-2859	263	4	.	.	PUNCT
dpc-2859	264	1	2001;85(5):404	2001;85(5):404	NUM
dpc-2859	264	2	-	-	SYM
dpc-2859	264	3	407	407	NUM
dpc-2859	264	4	.	.	PUNCT
dpc-2859	265	1	doi	doi	NOUN
dpc-2859	265	2	:	:	PUNCT
dpc-2859	265	3	10.1136	10.1136	NUM
dpc-2859	265	4	/	/	SYM
dpc-2859	265	5	adc.85.5.404	adc.85.5.404	NOUN
dpc-2859	265	6	.	.	PUNCT
dpc-2859	266	1	pmid	pmid	PROPN
dpc-2859	266	2	:	:	PUNCT
dpc-2859	266	3	11668104	11668104	NUM
dpc-2859	266	4	.	.	PUNCT
dpc-2859	267	1	pmcid	pmcid	NOUN
dpc-2859	267	2	:	:	PUNCT
dpc-2859	267	3	pmc1718983	pmc1718983	PROPN
dpc-2859	267	4	.	.	PUNCT
dpc-2859	268	1	36	36	NUM
dpc-2859	268	2	.	.	X
dpc-2859	268	3	erpolat	erpolat	PROPN
dpc-2859	268	4	s	s	PROPN
dpc-2859	268	5	,	,	PUNCT
dpc-2859	268	6	gorpelioglu	gorpelioglu	PROPN
dpc-2859	268	7	c	c	NOUN
dpc-2859	268	8	,	,	PUNCT
dpc-2859	268	9	sarifakioglu	sarifakioglu	PROPN
dpc-2859	268	10	e.	e.	PROPN
dpc-2859	268	11	isotretinoin	isotretinoin	PROPN
dpc-2859	268	12	associated	associate	VERB
dpc-2859	268	13	anal	anal	ADJ
dpc-2859	268	14	fissure	fissure	NOUN
dpc-2859	268	15	and	and	CCONJ
dpc-2859	268	16	rectal	rectal	ADJ
dpc-2859	268	17	bleeding	bleeding	NOUN
dpc-2859	268	18	:	:	PUNCT
dpc-2859	268	19	a	a	DET
dpc-2859	268	20	rare	rare	ADJ
dpc-2859	268	21	complication	complication	NOUN
dpc-2859	268	22	.	.	PUNCT
dpc-2859	269	1	int	int	NOUN
dpc-2859	269	2	j	j	PROPN
dpc-2859	269	3	dermatol	dermatol	NOUN
dpc-2859	269	4	.	.	PUNCT
dpc-2859	270	1	2012;51(3):358	2012;51(3):358	NOUN
dpc-2859	270	2	-	-	PUNCT
dpc-2859	270	3	359	359	NUM
dpc-2859	270	4	.	.	PUNCT
dpc-2859	271	1	doi	doi	NOUN
dpc-2859	271	2	:	:	PUNCT
dpc-2859	271	3	10.1111	10.1111	NUM
dpc-2859	271	4	/	/	SYM
dpc-2859	271	5	j.1365	j.1365	NOUN
dpc-2859	271	6	-4632.2010.04556.x	-4632.2010.04556.x	ADJ
dpc-2859	271	7	.	.	PUNCT
dpc-2859	272	1	pmid	pmid	NOUN
dpc-2859	272	2	:	:	PUNCT
dpc-2859	272	3	22348579	22348579	NUM
dpc-2859	272	4	.	.	PUNCT
dpc-2859	273	1	37	37	NUM
dpc-2859	273	2	.	.	PUNCT
dpc-2859	274	1	güngör	güngör	PROPN
dpc-2859	274	2	s	s	PROPN
dpc-2859	274	3	,	,	PUNCT
dpc-2859	274	4	gökdemir	gökdemir	PROPN
dpc-2859	274	5	g.	g.	PROPN
dpc-2859	274	6	anal	anal	ADJ
dpc-2859	274	7	fissure	fissure	NOUN
dpc-2859	274	8	and	and	CCONJ
dpc-2859	274	9	rectal	rectal	ADJ
dpc-2859	274	10	bleeding	bleeding	NOUN
dpc-2859	274	11	as	as	ADP
dpc-2859	274	12	a	a	DET
dpc-2859	274	13	complication	complication	NOUN
dpc-2859	274	14	of	of	ADP
dpc-2859	274	15	systemic	systemic	ADJ
dpc-2859	274	16	isotretinoin	isotretinoin	PROPN
dpc-2859	274	17	therapy	therapy	NOUN
dpc-2859	274	18	:	:	PUNCT
dpc-2859	274	19	dermatologists	dermatologist	NOUN
dpc-2859	274	20	know	know	VERB
dpc-2859	274	21	this	this	DET
dpc-2859	274	22	side	side	NOUN
dpc-2859	274	23	-	-	PUNCT
dpc-2859	274	24	effect	effect	NOUN
dpc-2859	274	25	,	,	PUNCT
dpc-2859	274	26	what	what	PRON
dpc-2859	274	27	about	about	ADP
dpc-2859	274	28	proctologists	proctologist	NOUN
dpc-2859	274	29	?	?	PUNCT
dpc-2859	275	1	colorectal	colorectal	ADJ
dpc-2859	275	2	dis	dis	PROPN
dpc-2859	275	3	.	.	PUNCT
dpc-2859	276	1	2013;15(9):1187	2013;15(9):1187	NUM
dpc-2859	276	2	-	-	SYM
dpc-2859	276	3	1188	1188	NUM
dpc-2859	276	4	.	.	PUNCT
dpc-2859	277	1	doi	doi	NOUN
dpc-2859	277	2	:	:	PUNCT
dpc-2859	277	3	10.1111	10.1111	NUM
dpc-2859	277	4	/	/	SYM
dpc-2859	277	5	codi.12294	codi.12294	PROPN
dpc-2859	277	6	.	.	PUNCT
dpc-2859	278	1	pmid	pmid	NOUN
dpc-2859	278	2	:	:	PUNCT
dpc-2859	278	3	23701373	23701373	NUM
dpc-2859	278	4	.	.	PUNCT
dpc-2859	279	1	38	38	NUM
dpc-2859	279	2	.	.	PUNCT
dpc-2859	279	3	karadağ	karadağ	NOUN
dpc-2859	279	4	as	as	ADP
dpc-2859	279	5	,	,	PUNCT
dpc-2859	279	6	çalka	çalka	PROPN
dpc-2859	279	7	ö	ö	PROPN
dpc-2859	279	8	,	,	PUNCT
dpc-2859	279	9	akdeniz	akdeniz	NOUN
dpc-2859	279	10	n.	n.	NOUN
dpc-2859	279	11	evaluation	evaluation	NOUN
dpc-2859	279	12	of	of	ADP
dpc-2859	279	13	side	side	NOUN
dpc-2859	279	14	effects	effect	NOUN
dpc-2859	279	15	of	of	ADP
dpc-2859	279	16	isotretinoin	isotretinoin	PROPN
dpc-2859	279	17	in	in	ADP
dpc-2859	279	18	150	150	NUM
dpc-2859	279	19	patients	patient	NOUN
dpc-2859	279	20	with	with	ADP
dpc-2859	279	21	acne	acne	NOUN
dpc-2859	279	22	vulgaris	vulgaris	NOUN
dpc-2859	279	23	.	.	PUNCT
dpc-2859	280	1	turkderm	turkderm	NOUN
dpc-2859	280	2	-	-	PUNCT
dpc-2859	280	3	turk	turk	NOUN
dpc-2859	280	4	arch	arch	ADJ
dpc-2859	280	5	dermatol	dermatol	NOUN
dpc-2859	280	6	venereol	venereol	NOUN
dpc-2859	280	7	.	.	PUNCT
dpc-2859	281	1	2011;45(1):37	2011;45(1):37	NUM
dpc-2859	281	2	-	-	SYM
dpc-2859	281	3	42	42	NUM
dpc-2859	281	4	.	.	PUNCT
dpc-2859	282	1	doi	doi	NOUN
dpc-2859	282	2	:	:	PUNCT
dpc-2859	282	3	10.4274	10.4274	NUM
dpc-2859	282	4	/turkderm.45.09	/turkderm.45.09	SYM
dpc-2859	282	5	.	.	PROPN
dpc-2859	283	1	39	39	NUM
dpc-2859	283	2	.	.	PUNCT
dpc-2859	284	1	çıkım	çıkım	PROPN
dpc-2859	284	2	aç	aç	PROPN
dpc-2859	284	3	,	,	PUNCT
dpc-2859	284	4	muammer	muammer	NOUN
dpc-2859	284	5	seyhan	seyhan	PROPN
dpc-2859	284	6	m.	m.	NOUN
dpc-2859	284	7	efficiency	efficiency	NOUN
dpc-2859	284	8	and	and	CCONJ
dpc-2859	284	9	side	side	NOUN
dpc-2859	284	10	effects	effect	NOUN
dpc-2859	284	11	of	of	ADP
dpc-2859	284	12	isotretinoin	isotretinoin	PROPN
dpc-2859	284	13	usage	usage	NOUN
dpc-2859	284	14	in	in	ADP
dpc-2859	284	15	the	the	DET
dpc-2859	284	16	treatment	treatment	NOUN
dpc-2859	284	17	of	of	ADP
dpc-2859	284	18	acne	acne	NOUN
dpc-2859	284	19	vulgaris	vulgaris	NOUN
dpc-2859	284	20	.	.	PUNCT
dpc-2859	285	1	türkderm	türkderm	NOUN
dpc-2859	285	2	.	.	PUNCT
dpc-2859	286	1	2008;42:51	2008;42:51	NUM
dpc-2859	286	2	-	-	SYM
dpc-2859	286	3	55	55	NUM
dpc-2859	286	4	.	.	PUNCT
dpc-2859	287	1	14	14	NUM
dpc-2859	287	2	.	.	PUNCT
dpc-2859	288	1	brodin	brodin	VERB
dpc-2859	288	2	mb	mb	X
dpc-2859	288	3	.	.	PUNCT
dpc-2859	288	4	inflammatory	inflammatory	ADJ
dpc-2859	288	5	bowel	bowel	NOUN
dpc-2859	288	6	disease	disease	NOUN
dpc-2859	288	7	and	and	CCONJ
dpc-2859	288	8	isotretinoin	isotretinoin	PROPN
dpc-2859	288	9	.	.	PUNCT
dpc-2859	289	1	j	j	PROPN
dpc-2859	289	2	am	be	AUX
dpc-2859	289	3	acad	acad	ADJ
dpc-2859	289	4	dermatol	dermatol	NOUN
dpc-2859	289	5	.	.	PUNCT
dpc-2859	290	1	1986;14(5	1986;14(5	NUM
dpc-2859	290	2	pt	pt	PROPN
dpc-2859	290	3	1):843	1):843	NUM
dpc-2859	290	4	.	.	PUNCT
dpc-2859	291	1	doi	doi	NOUN
dpc-2859	291	2	:	:	PUNCT
dpc-2859	291	3	10.1016	10.1016	NUM
dpc-2859	291	4	/	/	SYM
dpc-2859	291	5	s0190	s0190	ADJ
dpc-2859	291	6	-9622(86)80535	-9622(86)80535	NOUN
dpc-2859	291	7	-	-	PUNCT
dpc-2859	291	8	7	7	NUM
dpc-2859	291	9	.	.	PUNCT
dpc-2859	292	1	pmid	pmid	NOUN
dpc-2859	292	2	:	:	PUNCT
dpc-2859	292	3	2940270	2940270	NUM
dpc-2859	292	4	.	.	PUNCT
dpc-2859	293	1	15	15	NUM
dpc-2859	293	2	.	.	PUNCT
dpc-2859	293	3	radmanesh	radmanesh	PROPN
dpc-2859	293	4	m.	m.	NOUN
dpc-2859	293	5	anal	anal	ADJ
dpc-2859	293	6	fissure	fissure	NOUN
dpc-2859	293	7	,	,	PUNCT
dpc-2859	293	8	rectal	rectal	ADJ
dpc-2859	293	9	bleeding	bleeding	NOUN
dpc-2859	293	10	and	and	CCONJ
dpc-2859	293	11	proctitis	proctitis	NOUN
dpc-2859	293	12	as	as	ADP
dpc-2859	293	13	complications	complication	NOUN
dpc-2859	293	14	of	of	ADP
dpc-2859	293	15	systemic	systemic	ADJ
dpc-2859	293	16	isotretinoin	isotretinoin	PROPN
dpc-2859	293	17	therapy	therapy	NOUN
dpc-2859	293	18	:	:	PUNCT
dpc-2859	293	19	report	report	NOUN
dpc-2859	293	20	of	of	ADP
dpc-2859	293	21	two	two	NUM
dpc-2859	293	22	cases	case	NOUN
dpc-2859	293	23	.	.	PUNCT
dpc-2859	294	1	j	j	PROPN
dpc-2859	294	2	eur	eur	PROPN
dpc-2859	294	3	acad	acad	PROPN
dpc-2859	294	4	dermatol	dermatol	NOUN
dpc-2859	294	5	venereol	venereol	NOUN
dpc-2859	294	6	.	.	PUNCT
dpc-2859	295	1	2006;20(10):1394	2006;20(10):1394	X
dpc-2859	295	2	.	.	PUNCT
dpc-2859	295	3	doi	doi	NOUN
dpc-2859	295	4	:	:	PUNCT
dpc-2859	295	5	10.1111	10.1111	NUM
dpc-2859	295	6	/	/	SYM
dpc-2859	295	7	j.1468	j.1468	NOUN
dpc-2859	295	8	-	-	PUNCT
dpc-2859	295	9	3083.2006.01759.x	3083.2006.01759.x	PROPN
dpc-2859	295	10	.	.	PUNCT
dpc-2859	296	1	pmid	pmid	NOUN
dpc-2859	296	2	:	:	PUNCT
dpc-2859	296	3	17062102	17062102	NUM
dpc-2859	296	4	.	.	PUNCT
dpc-2859	297	1	16	16	NUM
dpc-2859	297	2	.	.	PUNCT
dpc-2859	298	1	james	james	PROPN
dpc-2859	298	2	wd	wd	PROPN
dpc-2859	298	3	,	,	PUNCT
dpc-2859	298	4	berger	berger	PROPN
dpc-2859	298	5	tg	tg	PROPN
dpc-2859	298	6	,	,	PUNCT
dpc-2859	298	7	elston	elston	PROPN
dpc-2859	298	8	dm	dm	PROPN
dpc-2859	298	9	.	.	PUNCT
dpc-2859	298	10	andrews	andrews	PROPN
dpc-2859	298	11	’	'	PUNCT
dpc-2859	298	12	diseases	disease	NOUN
dpc-2859	298	13	of	of	ADP
dpc-2859	298	14	the	the	DET
dpc-2859	298	15	skin	skin	NOUN
dpc-2859	298	16	:	:	PUNCT
dpc-2859	298	17	clinical	clinical	ADJ
dpc-2859	298	18	dermatology	dermatology	NOUN
dpc-2859	298	19	,	,	PUNCT
dpc-2859	298	20	(	(	PUNCT
dpc-2859	298	21	11th	11th	ADJ
dpc-2859	298	22	ed	ed	NOUN
dpc-2859	298	23	.	.	PUNCT
dpc-2859	298	24	)	)	PUNCT
dpc-2859	298	25	.	.	PUNCT
dpc-2859	299	1	philadelphia	philadelphia	PROPN
dpc-2859	299	2	,	,	PUNCT
dpc-2859	299	3	elsevier	elsevier	NOUN
dpc-2859	299	4	,	,	PUNCT
dpc-2859	299	5	2011:228e34	2011:228e34	NUM
dpc-2859	299	6	.	.	PROPN
dpc-2859	299	7	17	17	NUM
dpc-2859	299	8	.	.	PUNCT
dpc-2859	300	1	dubeau	dubeau	PROPN
dpc-2859	300	2	mf	mf	VERB
dpc-2859	300	3	,	,	PUNCT
dpc-2859	300	4	iacucci	iacucci	PROPN
dpc-2859	300	5	m	m	PROPN
dpc-2859	300	6	,	,	PUNCT
dpc-2859	300	7	beck	beck	PROPN
dpc-2859	300	8	pl	pl	PROPN
dpc-2859	300	9	,	,	PUNCT
dpc-2859	300	10	et	et	PROPN
dpc-2859	300	11	al	al	PROPN
dpc-2859	300	12	.	.	PROPN
dpc-2859	300	13	drug	drug	NOUN
dpc-2859	300	14	-	-	PUNCT
dpc-2859	300	15	induced	induce	VERB
dpc-2859	300	16	inflammatory	inflammatory	ADJ
dpc-2859	300	17	bowel	bowel	NOUN
dpc-2859	300	18	disease	disease	NOUN
dpc-2859	300	19	and	and	CCONJ
dpc-2859	300	20	ibd	ibd	NOUN
dpc-2859	300	21	-	-	PUNCT
dpc-2859	300	22	like	like	ADJ
dpc-2859	300	23	conditions	condition	NOUN
dpc-2859	300	24	.	.	PUNCT
dpc-2859	301	1	inflamm	inflamm	PROPN
dpc-2859	301	2	bowel	bowel	PROPN
dpc-2859	301	3	dis	dis	PROPN
dpc-2859	301	4	.	.	PUNCT
dpc-2859	302	1	2012;19(2):445	2012;19(2):445	NOUN
dpc-2859	302	2	-	-	PUNCT
dpc-2859	302	3	456	456	PROPN
dpc-2859	302	4	.	.	PUNCT
dpc-2859	303	1	doi	doi	NOUN
dpc-2859	303	2	:	:	PUNCT
dpc-2859	303	3	10.1002	10.1002	NUM
dpc-2859	303	4	/	/	SYM
dpc-2859	303	5	ibd.22990	ibd.22990	PROPN
dpc-2859	303	6	.	.	PUNCT
dpc-2859	304	1	pmid	pmid	NOUN
dpc-2859	304	2	:	:	PUNCT
dpc-2859	304	3	22573536	22573536	NUM
dpc-2859	304	4	.	.	PUNCT
dpc-2859	305	1	18	18	NUM
dpc-2859	305	2	.	.	PUNCT
dpc-2859	306	1	bremner	bremner	PROPN
dpc-2859	306	2	jd	jd	PROPN
dpc-2859	306	3	,	,	PUNCT
dpc-2859	306	4	shearer	shearer	PROPN
dpc-2859	306	5	kd	kd	PROPN
dpc-2859	306	6	,	,	PUNCT
dpc-2859	306	7	mccaffery	mccaffery	PROPN
dpc-2859	306	8	pj	pj	PROPN
dpc-2859	306	9	:	:	PUNCT
dpc-2859	306	10	retinoic	retinoic	PROPN
dpc-2859	306	11	acid	acid	PROPN
dpc-2859	306	12	and	and	CCONJ
dpc-2859	306	13	affective	affective	ADJ
dpc-2859	306	14	disorders	disorder	NOUN
dpc-2859	306	15	:	:	PUNCT
dpc-2859	306	16	the	the	DET
dpc-2859	306	17	evidence	evidence	NOUN
dpc-2859	306	18	for	for	ADP
dpc-2859	306	19	an	an	DET
dpc-2859	306	20	association	association	NOUN
dpc-2859	306	21	.	.	PUNCT
dpc-2859	307	1	j	j	PROPN
dpc-2859	307	2	clin	clin	PROPN
dpc-2859	307	3	psychiatry	psychiatry	PROPN
dpc-2859	307	4	.	.	PUNCT
dpc-2859	308	1	2012	2012	NUM
dpc-2859	308	2	;	;	PUNCT
dpc-2859	309	1	73(1):37	73(1):37	NUM
dpc-2859	309	2	-	-	SYM
dpc-2859	309	3	50	50	NUM
dpc-2859	309	4	.	.	PUNCT
dpc-2859	310	1	doi	doi	NOUN
dpc-2859	310	2	:	:	PUNCT
dpc-2859	310	3	10.4088	10.4088	NUM
dpc-2859	310	4	/	/	SYM
dpc-2859	310	5	jcp.10r05993	jcp.10r05993	NOUN
dpc-2859	310	6	.	.	PUNCT
dpc-2859	311	1	pmid	pmid	NOUN
dpc-2859	311	2	:	:	PUNCT
dpc-2859	311	3	21903028	21903028	NUM
dpc-2859	311	4	.	.	PUNCT
dpc-2859	312	1	pmcid	pmcid	NOUN
dpc-2859	312	2	:	:	PUNCT
dpc-2859	312	3	pmc3276716	pmc3276716	NOUN
dpc-2859	312	4	.	.	PUNCT
dpc-2859	313	1	19	19	NUM
dpc-2859	313	2	.	.	PUNCT
dpc-2859	313	3	rademaker	rademaker	PROPN
dpc-2859	313	4	m.	m.	NOUN
dpc-2859	313	5	adverse	adverse	ADJ
dpc-2859	313	6	effects	effect	NOUN
dpc-2859	313	7	of	of	ADP
dpc-2859	313	8	isotretinoin	isotretinoin	PROPN
dpc-2859	313	9	:	:	PUNCT
dpc-2859	313	10	a	a	DET
dpc-2859	313	11	restrospective	restrospective	ADJ
dpc-2859	313	12	review	review	NOUN
dpc-2859	313	13	of	of	ADP
dpc-2859	313	14	1743	1743	NUM
dpc-2859	313	15	patients	patient	NOUN
dpc-2859	313	16	started	start	VERB
dpc-2859	313	17	on	on	ADP
dpc-2859	313	18	isotretinoin	isotretinoin	PROPN
dpc-2859	313	19	.	.	PUNCT
dpc-2859	314	1	australas	australas	PROPN
dpc-2859	314	2	j	j	PROPN
dpc-2859	314	3	dermatol	dermatol	NOUN
dpc-2859	314	4	.	.	PUNCT
dpc-2859	315	1	2010;51(4):248	2010;51(4):248	NUM
dpc-2859	315	2	-	-	SYM
dpc-2859	315	3	253	253	NUM
dpc-2859	315	4	.	.	PUNCT
dpc-2859	315	5	doi	doi	NOUN
dpc-2859	315	6	:	:	PUNCT
dpc-2859	315	7	10.1111	10.1111	NUM
dpc-2859	315	8	/	/	SYM
dpc-2859	315	9	j.1440	j.1440	PROPN
dpc-2859	315	10	-	-	PUNCT
dpc-2859	315	11	0960.2010.00657.x	0960.2010.00657.x	NOUN
dpc-2859	315	12	.	.	PUNCT
dpc-2859	316	1	pmid	pmid	NOUN
dpc-2859	316	2	:	:	PUNCT
dpc-2859	316	3	21198520	21198520	NUM
dpc-2859	316	4	.	.	PUNCT
dpc-2859	317	1	20	20	NUM
dpc-2859	317	2	.	.	PUNCT
dpc-2859	318	1	katsambas	katsambas	PROPN
dpc-2859	318	2	a	a	PRON
dpc-2859	318	3	,	,	PUNCT
dpc-2859	318	4	papakonstantinou	papakonstantinou	PROPN
dpc-2859	318	5	a.	a.	NOUN
dpc-2859	318	6	acne	acne	PROPN
dpc-2859	318	7	:	:	PUNCT
dpc-2859	318	8	systemic	systemic	ADJ
dpc-2859	318	9	treatment	treatment	NOUN
dpc-2859	318	10	.	.	PUNCT
dpc-2859	319	1	clin	clin	PROPN
dpc-2859	319	2	dermatol	dermatol	NOUN
dpc-2859	319	3	.	.	PUNCT
dpc-2859	320	1	2004	2004	NUM
dpc-2859	320	2	;	;	PUNCT
dpc-2859	321	1	22(5):412	22(5):412	NOUN
dpc-2859	321	2	-	-	SYM
dpc-2859	321	3	418	418	NUM
dpc-2859	321	4	.	.	PUNCT
dpc-2859	322	1	doi	doi	NOUN
dpc-2859	322	2	:	:	PUNCT
dpc-2859	322	3	10.1016	10.1016	NUM
dpc-2859	322	4	/	/	SYM
dpc-2859	322	5	j.clindermatol.2004.03.014	j.clindermatol.2004.03.014	PROPN
dpc-2859	322	6	.	.	PUNCT
dpc-2859	323	1	pmid	pmid	NOUN
dpc-2859	323	2	:	:	PUNCT
dpc-2859	323	3	15556728	15556728	NUM
dpc-2859	323	4	.	.	PUNCT
dpc-2859	324	1	21	21	NUM
dpc-2859	324	2	.	.	PUNCT
dpc-2859	325	1	brzezinski	brzezinski	PROPN
dpc-2859	325	2	p	p	PROPN
dpc-2859	325	3	,	,	PUNCT
dpc-2859	325	4	borowska	borowska	PROPN
dpc-2859	325	5	k	k	PROPN
dpc-2859	325	6	,	,	PUNCT
dpc-2859	325	7	chiriac	chiriac	PROPN
dpc-2859	325	8	a	a	PRON
dpc-2859	325	9	,	,	PUNCT
dpc-2859	325	10	smigielski	smigielski	ADJ
dpc-2859	325	11	j.	j.	PROPN
dpc-2859	325	12	adverse	adverse	ADJ
dpc-2859	325	13	effects	effect	NOUN
dpc-2859	325	14	of	of	ADP
dpc-2859	325	15	isotretinoin	isotretinoin	PROPN
dpc-2859	325	16	:	:	PUNCT
dpc-2859	325	17	a	a	DET
dpc-2859	325	18	large	large	ADJ
dpc-2859	325	19	,	,	PUNCT
dpc-2859	325	20	retrospective	retrospective	ADJ
dpc-2859	325	21	review	review	NOUN
dpc-2859	325	22	.	.	PUNCT
dpc-2859	326	1	dermatol	dermatol	NOUN
dpc-2859	326	2	ther	ther	ADV
dpc-2859	326	3	.	.	PUNCT
dpc-2859	327	1	2017;30(4	2017;30(4	NUM
dpc-2859	327	2	)	)	PUNCT
dpc-2859	327	3	.	.	PUNCT
dpc-2859	328	1	doi	doi	NOUN
dpc-2859	328	2	:	:	PUNCT
dpc-2859	328	3	10.1111	10.1111	NUM
dpc-2859	328	4	/	/	SYM
dpc-2859	328	5	dth.12483	dth.12483	NOUN
dpc-2859	328	6	.	.	PUNCT
dpc-2859	329	1	pmid	pmid	NOUN
dpc-2859	329	2	:	:	PUNCT
dpc-2859	329	3	28295859	28295859	NUM
dpc-2859	329	4	.	.	PUNCT
dpc-2859	330	1	22	22	NUM
dpc-2859	330	2	.	.	PUNCT
dpc-2859	331	1	prevost	prevost	PROPN
dpc-2859	331	2	n	n	CCONJ
dpc-2859	331	3	,	,	PUNCT
dpc-2859	331	4	english	english	PROPN
dpc-2859	331	5	jc	jc	PROPN
dpc-2859	331	6	.	.	PROPN
dpc-2859	331	7	isotretinoin	isotretinoin	PROPN
dpc-2859	331	8	:	:	PUNCT
dpc-2859	331	9	update	update	NOUN
dpc-2859	331	10	on	on	ADP
dpc-2859	331	11	controversial	controversial	ADJ
dpc-2859	331	12	issues	issue	NOUN
dpc-2859	331	13	.	.	PUNCT
dpc-2859	332	1	j	j	PROPN
dpc-2859	332	2	pediatr	pediatr	PROPN
dpc-2859	332	3	adolesc	adolesc	PROPN
dpc-2859	332	4	gynecol	gynecol	PROPN
dpc-2859	332	5	.	.	PUNCT
dpc-2859	332	6	2013	2013	NUM
dpc-2859	332	7	;	;	PUNCT
dpc-2859	332	8	26(5):290	26(5):290	PROPN
dpc-2859	332	9	-	-	SYM
dpc-2859	332	10	293	293	NUM
dpc-2859	332	11	.	.	PUNCT
dpc-2859	333	1	doi	doi	NOUN
dpc-2859	333	2	:	:	PUNCT
dpc-2859	333	3	10.1016	10.1016	NUM
dpc-2859	333	4	/	/	SYM
dpc-2859	333	5	j.jpag.2013.05.007	j.jpag.2013.05.007	PROPN
dpc-2859	333	6	.	.	PUNCT
dpc-2859	334	1	pmid	pmid	NOUN
dpc-2859	334	2	:	:	PUNCT
dpc-2859	334	3	24147278	24147278	NUM
dpc-2859	334	4	.	.	PUNCT
dpc-2859	335	1	23	23	NUM
dpc-2859	335	2	.	.	PUNCT
dpc-2859	336	1	landis	landis	PROPN
dpc-2859	336	2	mn	mn	PROPN
dpc-2859	336	3	.	.	PUNCT
dpc-2859	337	1	optimizing	optimize	VERB
dpc-2859	337	2	isotretinoin	isotretinoin	PROPN
dpc-2859	337	3	treatment	treatment	NOUN
dpc-2859	337	4	of	of	ADP
dpc-2859	337	5	acne	acne	NOUN
dpc-2859	337	6	:	:	PUNCT
dpc-2859	337	7	update	update	NOUN
dpc-2859	337	8	on	on	ADP
dpc-2859	337	9	current	current	ADJ
dpc-2859	337	10	recommendations	recommendation	NOUN
dpc-2859	337	11	for	for	ADP
dpc-2859	337	12	monitoring	monitoring	NOUN
dpc-2859	337	13	,	,	PUNCT
dpc-2859	337	14	dosing	dosing	NOUN
dpc-2859	337	15	,	,	PUNCT
dpc-2859	337	16	safety	safety	NOUN
dpc-2859	337	17	,	,	PUNCT
dpc-2859	337	18	adverse	adverse	ADJ
dpc-2859	337	19	effects	effect	NOUN
dpc-2859	337	20	,	,	PUNCT
dpc-2859	337	21	compliance	compliance	NOUN
dpc-2859	337	22	,	,	PUNCT
dpc-2859	337	23	and	and	CCONJ
dpc-2859	337	24	outcomes	outcome	NOUN
dpc-2859	337	25	.	.	PUNCT
dpc-2859	338	1	am	be	AUX
dpc-2859	338	2	j	j	PROPN
dpc-2859	338	3	clin	clin	PROPN
dpc-2859	338	4	dermatol	dermatol	NOUN
dpc-2859	338	5	.	.	PUNCT
dpc-2859	339	1	2020;21(3):411	2020;21(3):411	PROPN
dpc-2859	339	2	-	-	PUNCT
dpc-2859	339	3	419	419	NUM
dpc-2859	339	4	.	.	PUNCT
dpc-2859	340	1	doi	doi	NOUN
dpc-2859	340	2	:	:	PUNCT
dpc-2859	340	3	10.1007	10.1007	NUM
dpc-2859	340	4	/	/	SYM
dpc-2859	340	5	s40257	s40257	NOUN
dpc-2859	340	6	-	-	PUNCT
dpc-2859	340	7	020	020	NUM
dpc-2859	340	8	-	-	PUNCT
dpc-2859	340	9	00508	00508	NUM
dpc-2859	340	10	-	-	PUNCT
dpc-2859	340	11	0	0	NUM
dpc-2859	340	12	.	.	PUNCT
dpc-2859	341	1	pmid	pmid	NOUN
dpc-2859	341	2	:	:	PUNCT
dpc-2859	341	3	32107726	32107726	NUM
dpc-2859	341	4	.	.	PUNCT
dpc-2859	342	1	24	24	NUM
dpc-2859	342	2	.	.	X
dpc-2859	342	3	neudorfer	neudorfer	PROPN
dpc-2859	342	4	m	m	PROPN
dpc-2859	342	5	,	,	PUNCT
dpc-2859	342	6	goldshtein	goldshtein	VERB
dpc-2859	342	7	i	i	PRON
dpc-2859	342	8	,	,	PUNCT
dpc-2859	342	9	shamai	shamai	NOUN
dpc-2859	342	10	-	-	PUNCT
dpc-2859	342	11	lubovitz	lubovitz	NOUN
dpc-2859	342	12	o	o	NOUN
dpc-2859	342	13	,	,	PUNCT
dpc-2859	342	14	chodick	chodick	NOUN
dpc-2859	342	15	g	g	PROPN
dpc-2859	342	16	,	,	PUNCT
dpc-2859	342	17	dadon	dadon	PROPN
dpc-2859	342	18	y	y	NOUN
dpc-2859	342	19	,	,	PUNCT
dpc-2859	342	20	shalev	shalev	NOUN
dpc-2859	342	21	v.	v.	ADP
dpc-2859	342	22	ocular	ocular	ADJ
dpc-2859	342	23	adverse	adverse	ADJ
dpc-2859	342	24	effects	effect	NOUN
dpc-2859	342	25	of	of	ADP
dpc-2859	342	26	systemic	systemic	ADJ
dpc-2859	342	27	treatment	treatment	NOUN
dpc-2859	342	28	with	with	ADP
dpc-2859	342	29	isotretinoin	isotretinoin	PROPN
dpc-2859	342	30	.	.	PUNCT
dpc-2859	343	1	arch	arch	ADJ
dpc-2859	343	2	dermatol	dermatol	NOUN
dpc-2859	343	3	.	.	PUNCT
dpc-2859	344	1	2012;148(7):803	2012;148(7):803	NUM
dpc-2859	344	2	-	-	SYM
dpc-2859	344	3	808	808	NUM
dpc-2859	344	4	.	.	PUNCT
dpc-2859	344	5	doi	doi	NOUN
dpc-2859	344	6	:	:	PUNCT
dpc-2859	344	7	10.1001	10.1001	NUM
dpc-2859	344	8	/	/	SYM
dpc-2859	344	9	archdermatol.2012.352	archdermatol.2012.352	PROPN
dpc-2859	344	10	.	.	PUNCT
dpc-2859	345	1	pmid	pmid	NOUN
dpc-2859	345	2	:	:	PUNCT
dpc-2859	345	3	22508771	22508771	NUM
dpc-2859	345	4	.	.	PUNCT
dpc-2859	346	1	25	25	NUM
dpc-2859	346	2	.	.	PUNCT
dpc-2859	347	1	kaymak	kaymak	PROPN
dpc-2859	347	2	y	y	PROPN
dpc-2859	347	3	,	,	PUNCT
dpc-2859	347	4	ilter	ilter	PROPN
dpc-2859	347	5	n.	n.	PROPN
dpc-2859	348	1	the	the	DET
dpc-2859	348	2	results	result	NOUN
dpc-2859	348	3	and	and	CCONJ
dpc-2859	348	4	side	side	NOUN
dpc-2859	348	5	effects	effect	NOUN
dpc-2859	348	6	of	of	ADP
dpc-2859	348	7	systemic	systemic	ADJ
dpc-2859	348	8	isotretinoin	isotretinoin	PROPN
dpc-2859	348	9	treatment	treatment	NOUN
dpc-2859	348	10	in	in	ADP
dpc-2859	348	11	100	100	NUM
dpc-2859	348	12	patients	patient	NOUN
dpc-2859	348	13	with	with	ADP
dpc-2859	348	14	acne	acne	NOUN
dpc-2859	348	15	vulgaris	vulgaris	NOUN
dpc-2859	348	16	.	.	PUNCT
dpc-2859	349	1	dermatol	dermatol	NOUN
dpc-2859	349	2	nurs	nur	VERB
dpc-2859	349	3	.	.	PUNCT
dpc-2859	350	1	2006;18(6):576	2006;18(6):576	PROPN
dpc-2859	350	2	-	-	PUNCT
dpc-2859	350	3	580	580	NUM
dpc-2859	350	4	.	.	PUNCT
dpc-2859	351	1	pmid	pmid	NOUN
dpc-2859	351	2	:	:	PUNCT
dpc-2859	351	3	17286159	17286159	NUM
dpc-2859	351	4	.	.	PUNCT
dpc-2859	352	1	26	26	NUM
dpc-2859	352	2	.	.	PUNCT
dpc-2859	353	1	crockett	crockett	PROPN
dpc-2859	353	2	sd	sd	PROPN
dpc-2859	353	3	,	,	PUNCT
dpc-2859	353	4	porter	porter	NOUN
dpc-2859	353	5	cq	cq	PROPN
dpc-2859	353	6	,	,	PUNCT
dpc-2859	353	7	martin	martin	PROPN
dpc-2859	353	8	cf	cf	PROPN
dpc-2859	353	9	,	,	PUNCT
dpc-2859	353	10	sandler	sandler	NOUN
dpc-2859	353	11	rs	rs	PROPN
dpc-2859	353	12	,	,	PUNCT
dpc-2859	353	13	kappelman	kappelman	PROPN
dpc-2859	353	14	md	md	PROPN
dpc-2859	353	15	.	.	PROPN
dpc-2859	354	1	isotretinoin	isotretinoin	PROPN
dpc-2859	354	2	use	use	NOUN
dpc-2859	354	3	and	and	CCONJ
dpc-2859	354	4	the	the	DET
dpc-2859	354	5	risk	risk	NOUN
dpc-2859	354	6	of	of	ADP
dpc-2859	354	7	inflammatory	inflammatory	ADJ
dpc-2859	354	8	bowel	bowel	NOUN
dpc-2859	354	9	disease	disease	NOUN
dpc-2859	354	10	:	:	PUNCT
dpc-2859	354	11	a	a	DET
dpc-2859	354	12	case	case	NOUN
dpc-2859	354	13	-	-	PUNCT
dpc-2859	354	14	control	control	NOUN
dpc-2859	354	15	study	study	NOUN
dpc-2859	354	16	.	.	PUNCT
dpc-2859	355	1	am	be	AUX
dpc-2859	355	2	j	j	PROPN
dpc-2859	355	3	gastroenterol	gastroenterol	NOUN
dpc-2859	355	4	.	.	PUNCT
dpc-2859	356	1	2010;105(9):19861993	2010;105(9):19861993	NUM
dpc-2859	356	2	.	.	PUNCT
dpc-2859	357	1	doi	doi	NOUN
dpc-2859	357	2	:	:	PUNCT
dpc-2859	357	3	10.1038	10.1038	NUM
dpc-2859	357	4	/	/	SYM
dpc-2859	357	5	ajg.2010.124	ajg.2010.124	NOUN
dpc-2859	357	6	.	.	PUNCT
dpc-2859	358	1	pmid	pmid	NOUN
dpc-2859	358	2	:	:	PUNCT
dpc-2859	358	3	20354506	20354506	NUM
dpc-2859	358	4	.	.	PUNCT
dpc-2859	359	1	pmcid	pmcid	NOUN
dpc-2859	359	2	:	:	PUNCT
dpc-2859	359	3	pmc3073620	pmc3073620	NOUN
dpc-2859	359	4	.	.	PUNCT
dpc-2859	360	1	27	27	NUM
dpc-2859	360	2	.	.	PUNCT
dpc-2859	361	1	passier	passier	PROPN
dpc-2859	361	2	jl	jl	PROPN
dpc-2859	361	3	,	,	PUNCT
dpc-2859	361	4	srivastava	srivastava	PROPN
dpc-2859	361	5	n	n	PROPN
dpc-2859	361	6	,	,	PUNCT
dpc-2859	361	7	van	van	PROPN
dpc-2859	361	8	puijenbroek	puijenbroek	PROPN
dpc-2859	361	9	ep	ep	PROPN
dpc-2859	361	10	:	:	PUNCT
dpc-2859	361	11	isotretinoin	isotretinoin	PROPN
dpc-2859	361	12	-	-	PUNCT
dpc-2859	361	13	induced	induce	VERB
dpc-2859	361	14	inflammatory	inflammatory	ADJ
dpc-2859	361	15	bowel	bowel	NOUN
dpc-2859	361	16	disease	disease	NOUN
dpc-2859	361	17	.	.	PUNCT
dpc-2859	362	1	neth	neth	PROPN
dpc-2859	362	2	j	j	PROPN
dpc-2859	362	3	med	med	PROPN
dpc-2859	362	4	.	.	PUNCT
dpc-2859	363	1	2006;64(2):52	2006;64(2):52	NUM
dpc-2859	363	2	-	-	SYM
dpc-2859	363	3	54	54	NUM
dpc-2859	363	4	.	.	PUNCT
dpc-2859	364	1	pmid	pmid	NOUN
dpc-2859	364	2	:	:	PUNCT
dpc-2859	364	3	16517990	16517990	NUM
dpc-2859	364	4	.	.	PUNCT