id	sid	tid	token	lemma	pos
dpc-3458	1	1	dermatology	dermatology	NOUN
dpc-3458	1	2	:	:	PUNCT
dpc-3458	1	3	practical	practical	ADJ
dpc-3458	1	4	and	and	CCONJ
dpc-3458	1	5	conceptual	conceptual	ADJ
dpc-3458	1	6	research	research	NOUN
dpc-3458	1	7	letter	letter	NOUN
dpc-3458	2	1	|	|	ADV
dpc-3458	2	2	dermatol	dermatol	ADJ
dpc-3458	2	3	pract	pract	NOUN
dpc-3458	2	4	concept	concept	NOUN
dpc-3458	2	5	.	.	PUNCT
dpc-3458	3	1	2024;14(1):e2024020	2024;14(1):e2024020	NUM
dpc-3458	3	2	1	1	NUM
dpc-3458	3	3	diffuse	diffuse	NOUN
dpc-3458	3	4	melanosis	melanosis	NOUN
dpc-3458	3	5	cutis	cutis	NOUN
dpc-3458	3	6	in	in	ADP
dpc-3458	3	7	the	the	DET
dpc-3458	3	8	era	era	NOUN
dpc-3458	3	9	of	of	ADP
dpc-3458	3	10	 	 	SPACE
dpc-3458	3	11	targeted	target	VERB
dpc-3458	3	12	 	 	SPACE
dpc-3458	3	13	therapy	therapy	NOUN
dpc-3458	3	14	fernanda	fernanda	PROPN
dpc-3458	3	15	luiza	luiza	PROPN
dpc-3458	3	16	staub1	staub1	PROPN
dpc-3458	3	17	,	,	PUNCT
dpc-3458	3	18	bruna	bruna	PROPN
dpc-3458	3	19	ossanai	ossanai	ADJ
dpc-3458	3	20	schoenardie1	schoenardie1	PROPN
dpc-3458	3	21	,	,	PUNCT
dpc-3458	3	22	renan	renan	PROPN
dpc-3458	3	23	rangel	rangel	PROPN
dpc-3458	3	24	bonamigo1,2	bonamigo1,2	PROPN
dpc-3458	3	25	,	,	PUNCT
dpc-3458	3	26	juliano	juliano	PROPN
dpc-3458	3	27	 	 	SPACE
dpc-3458	3	28	peruzzo1	peruzzo1	PROPN
dpc-3458	3	29	1	1	NUM
dpc-3458	3	30	department	department	NOUN
dpc-3458	3	31	of	of	ADP
dpc-3458	3	32	dermatology	dermatology	NOUN
dpc-3458	3	33	,	,	PUNCT
dpc-3458	3	34	hospital	hospital	NOUN
dpc-3458	3	35	de	de	X
dpc-3458	3	36	clínicas	clínicas	X
dpc-3458	3	37	de	de	PROPN
dpc-3458	3	38	porto	porto	PROPN
dpc-3458	3	39	alegre	alegre	PROPN
dpc-3458	3	40	,	,	PUNCT
dpc-3458	3	41	porto	porto	PROPN
dpc-3458	3	42	alegre	alegre	PROPN
dpc-3458	3	43	,	,	PUNCT
dpc-3458	3	44	rio	rio	NOUN
dpc-3458	3	45	grande	grande	PROPN
dpc-3458	3	46	do	do	AUX
dpc-3458	3	47	sul	sul	PROPN
dpc-3458	3	48	,	,	PUNCT
dpc-3458	3	49	brazil	brazil	PROPN
dpc-3458	3	50	2	2	NUM
dpc-3458	3	51	universidade	universidade	NOUN
dpc-3458	3	52	federal	federal	PROPN
dpc-3458	3	53	do	do	AUX
dpc-3458	3	54	rio	rio	PROPN
dpc-3458	3	55	grande	grande	PROPN
dpc-3458	3	56	do	do	AUX
dpc-3458	3	57	sul	sul	PROPN
dpc-3458	3	58	,	,	PUNCT
dpc-3458	3	59	porto	porto	PROPN
dpc-3458	3	60	alegre	alegre	PROPN
dpc-3458	3	61	,	,	PUNCT
dpc-3458	3	62	rio	rio	NOUN
dpc-3458	3	63	grande	grande	PROPN
dpc-3458	3	64	do	do	AUX
dpc-3458	3	65	sul	sul	PROPN
dpc-3458	3	66	,	,	PUNCT
dpc-3458	3	67	brazil	brazil	PROPN
dpc-3458	3	68	key	key	ADJ
dpc-3458	3	69	words	word	NOUN
dpc-3458	3	70	:	:	PUNCT
dpc-3458	3	71	melanoma	melanoma	NOUN
dpc-3458	3	72	,	,	PUNCT
dpc-3458	3	73	target	target	NOUN
dpc-3458	3	74	therapy	therapy	NOUN
dpc-3458	3	75	,	,	PUNCT
dpc-3458	3	76	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	3	77	,	,	PUNCT
dpc-3458	3	78	metastatic	metastatic	ADJ
dpc-3458	3	79	melanoma	melanoma	NOUN
dpc-3458	3	80	,	,	PUNCT
dpc-3458	3	81	pdl-1	pdl-1	ADJ
dpc-3458	3	82	inhibitors	inhibitor	NOUN
dpc-3458	3	83	citation	citation	NOUN
dpc-3458	3	84	:	:	PUNCT
dpc-3458	3	85	staub	staub	NOUN
dpc-3458	3	86	f	f	PROPN
dpc-3458	3	87	,	,	PUNCT
dpc-3458	3	88	ossanai	ossanai	ADJ
dpc-3458	3	89	schoenardie	schoenardie	NOUN
dpc-3458	3	90	,	,	PUNCT
dpc-3458	3	91	rangel	rangel	NOUN
dpc-3458	3	92	bonamigo	bonamigo	ADJ
dpc-3458	3	93	r	r	PROPN
dpc-3458	3	94	,	,	PUNCT
dpc-3458	3	95	peruzzo	peruzzo	NOUN
dpc-3458	3	96	j.	j.	PROPN
dpc-3458	3	97	diffuse	diffuse	PROPN
dpc-3458	3	98	melanosis	melanosis	PROPN
dpc-3458	3	99	cutis	cutis	NOUN
dpc-3458	3	100	in	in	ADP
dpc-3458	3	101	the	the	DET
dpc-3458	3	102	era	era	NOUN
dpc-3458	3	103	of	of	ADP
dpc-3458	3	104	targeted	target	VERB
dpc-3458	3	105	therapy	therapy	NOUN
dpc-3458	3	106	.	.	PUNCT
dpc-3458	4	1	dermatol	dermatol	NOUN
dpc-3458	4	2	pract	pract	PROPN
dpc-3458	4	3	concept	concept	NOUN
dpc-3458	4	4	.	.	PUNCT
dpc-3458	5	1	2024;14(1):e2024020	2024;14(1):e2024020	X
dpc-3458	5	2	.	.	PUNCT
dpc-3458	5	3	doi	doi	PROPN
dpc-3458	5	4	:	:	PUNCT
dpc-3458	5	5	https://doi.org/10.5826/dpc.1401a20	https://doi.org/10.5826/dpc.1401a20	PROPN
dpc-3458	5	6	accepted	accept	VERB
dpc-3458	5	7	:	:	PUNCT
dpc-3458	5	8	november	november	PROPN
dpc-3458	5	9	7	7	NUM
dpc-3458	5	10	,	,	PUNCT
dpc-3458	5	11	2023	2023	NUM
dpc-3458	5	12	;	;	PUNCT
dpc-3458	5	13	published	publish	VERB
dpc-3458	5	14	:	:	PUNCT
dpc-3458	5	15	january	january	PROPN
dpc-3458	5	16	2024	2024	NUM
dpc-3458	6	1	copyright	copyright	NOUN
dpc-3458	6	2	:	:	PUNCT
dpc-3458	6	3	©	©	PROPN
dpc-3458	6	4	2024	2024	NUM
dpc-3458	6	5	staub	staub	NOUN
dpc-3458	6	6	et	et	PROPN
dpc-3458	6	7	al	al	PROPN
dpc-3458	6	8	.	.	PUNCT
dpc-3458	7	1	this	this	PRON
dpc-3458	7	2	is	be	AUX
dpc-3458	7	3	an	an	DET
dpc-3458	7	4	open	open	ADJ
dpc-3458	7	5	-	-	PUNCT
dpc-3458	7	6	access	access	NOUN
dpc-3458	7	7	article	article	NOUN
dpc-3458	7	8	distributed	distribute	VERB
dpc-3458	7	9	under	under	ADP
dpc-3458	7	10	the	the	DET
dpc-3458	7	11	terms	term	NOUN
dpc-3458	7	12	of	of	ADP
dpc-3458	7	13	the	the	DET
dpc-3458	7	14	creative	creative	ADJ
dpc-3458	7	15	commons	common	NOUN
dpc-3458	7	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-3458	7	17	license	license	NOUN
dpc-3458	7	18	(	(	PUNCT
dpc-3458	7	19	by	by	ADP
dpc-3458	7	20	-	-	PUNCT
dpc-3458	7	21	nc-4.0	nc-4.0	NOUN
dpc-3458	7	22	)	)	PUNCT
dpc-3458	7	23	,	,	PUNCT
dpc-3458	7	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-3458	7	25	,	,	PUNCT
dpc-3458	7	26	which	which	PRON
dpc-3458	7	27	permits	permit	VERB
dpc-3458	7	28	unrestricted	unrestricted	ADJ
dpc-3458	7	29	noncommercial	noncommercial	ADJ
dpc-3458	7	30	use	use	NOUN
dpc-3458	7	31	,	,	PUNCT
dpc-3458	7	32	distribution	distribution	NOUN
dpc-3458	7	33	,	,	PUNCT
dpc-3458	7	34	and	and	CCONJ
dpc-3458	7	35	reproduction	reproduction	NOUN
dpc-3458	7	36	in	in	ADP
dpc-3458	7	37	any	any	DET
dpc-3458	7	38	medium	medium	NOUN
dpc-3458	7	39	,	,	PUNCT
dpc-3458	7	40	provided	provide	VERB
dpc-3458	7	41	the	the	DET
dpc-3458	7	42	original	original	ADJ
dpc-3458	7	43	authors	author	NOUN
dpc-3458	7	44	and	and	CCONJ
dpc-3458	7	45	source	source	NOUN
dpc-3458	7	46	are	be	AUX
dpc-3458	7	47	credited	credit	VERB
dpc-3458	7	48	.	.	PUNCT
dpc-3458	8	1	funding	funding	NOUN
dpc-3458	8	2	:	:	PUNCT
dpc-3458	8	3	none	none	NOUN
dpc-3458	8	4	.	.	PUNCT
dpc-3458	9	1	competing	compete	VERB
dpc-3458	9	2	interests	interest	NOUN
dpc-3458	9	3	:	:	PUNCT
dpc-3458	9	4	none	none	NOUN
dpc-3458	9	5	.	.	PUNCT
dpc-3458	10	1	authorship	authorship	NOUN
dpc-3458	10	2	:	:	PUNCT
dpc-3458	10	3	all	all	DET
dpc-3458	10	4	authors	author	NOUN
dpc-3458	10	5	have	have	AUX
dpc-3458	10	6	contributed	contribute	VERB
dpc-3458	10	7	significantly	significantly	ADV
dpc-3458	10	8	to	to	ADP
dpc-3458	10	9	this	this	DET
dpc-3458	10	10	publication	publication	NOUN
dpc-3458	10	11	.	.	PUNCT
dpc-3458	11	1	corresponding	correspond	VERB
dpc-3458	11	2	author	author	NOUN
dpc-3458	11	3	:	:	PUNCT
dpc-3458	11	4	juliano	juliano	PROPN
dpc-3458	11	5	peruzzo	peruzzo	PROPN
dpc-3458	11	6	,	,	PUNCT
dpc-3458	11	7	rua	rua	PROPN
dpc-3458	11	8	ramiro	ramiro	PROPN
dpc-3458	11	9	barcelos	barcelos	PROPN
dpc-3458	11	10	,	,	PUNCT
dpc-3458	11	11	2350	2350	NUM
dpc-3458	11	12	90035	90035	NUM
dpc-3458	11	13	-	-	SYM
dpc-3458	11	14	007	007	NUM
dpc-3458	11	15	–	–	PUNCT
dpc-3458	11	16	porto	porto	NOUN
dpc-3458	11	17	alegre	alegre	NOUN
dpc-3458	11	18	–	–	PUNCT
dpc-3458	11	19	rs	rs	NOUN
dpc-3458	11	20	,	,	PUNCT
dpc-3458	11	21	brazil	brazil	PROPN
dpc-3458	11	22	.	.	PUNCT
dpc-3458	12	1	phone	phone	NOUN
dpc-3458	12	2	:	:	PUNCT
dpc-3458	13	1	+55	+55	PROPN
dpc-3458	13	2	51	51	NUM
dpc-3458	13	3	33598571	33598571	NUM
dpc-3458	13	4	e	e	NOUN
dpc-3458	13	5	-	-	NOUN
dpc-3458	13	6	mail	mail	NOUN
dpc-3458	13	7	:	:	PUNCT
dpc-3458	13	8	julperuzzo@hcpa.edu.br	julperuzzo@hcpa.edu.br	NOUN
dpc-3458	13	9	introduction	introduction	NOUN
dpc-3458	13	10	metastatic	metastatic	ADJ
dpc-3458	13	11	melanoma	melanoma	NOUN
dpc-3458	13	12	can	can	AUX
dpc-3458	13	13	rarely	rarely	ADV
dpc-3458	13	14	present	present	VERB
dpc-3458	13	15	as	as	ADP
dpc-3458	13	16	a	a	DET
dpc-3458	13	17	diffuse	diffuse	ADJ
dpc-3458	13	18	bluish	bluish	ADJ
dpc-3458	13	19	gray	gray	ADJ
dpc-3458	13	20	discoloration	discoloration	NOUN
dpc-3458	13	21	of	of	ADP
dpc-3458	13	22	the	the	DET
dpc-3458	13	23	skin	skin	NOUN
dpc-3458	13	24	,	,	PUNCT
dpc-3458	13	25	known	know	VERB
dpc-3458	13	26	as	as	ADP
dpc-3458	13	27	diffuse	diffuse	PROPN
dpc-3458	13	28	melanosis	melanosis	NOUN
dpc-3458	13	29	cutis	cutis	NOUN
dpc-3458	13	30	(	(	PUNCT
dpc-3458	13	31	dmc	dmc	PROPN
dpc-3458	13	32	)	)	PUNCT
dpc-3458	14	1	[	[	X
dpc-3458	14	2	1,2	1,2	NUM
dpc-3458	14	3	]	]	PUNCT
dpc-3458	14	4	.	.	PUNCT
dpc-3458	15	1	as	as	SCONJ
dpc-3458	15	2	it	it	PRON
dpc-3458	15	3	can	can	AUX
dpc-3458	15	4	negatively	negatively	ADV
dpc-3458	15	5	influence	influence	VERB
dpc-3458	15	6	quality	quality	NOUN
dpc-3458	15	7	of	of	ADP
dpc-3458	15	8	life	life	NOUN
dpc-3458	15	9	,	,	PUNCT
dpc-3458	15	10	therapeutic	therapeutic	ADJ
dpc-3458	15	11	options	option	NOUN
dpc-3458	15	12	for	for	ADP
dpc-3458	15	13	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	15	14	are	be	AUX
dpc-3458	15	15	crucial	crucial	ADJ
dpc-3458	15	16	.	.	PUNCT
dpc-3458	16	1	case	case	NOUN
dpc-3458	16	2	presentation	presentation	NOUN
dpc-3458	16	3	a	a	DET
dpc-3458	16	4	47	47	NUM
dpc-3458	16	5	-	-	PUNCT
dpc-3458	16	6	year	year	NOUN
dpc-3458	16	7	-	-	PUNCT
dpc-3458	16	8	old	old	ADJ
dpc-3458	16	9	woman	woman	NOUN
dpc-3458	16	10	was	be	AUX
dpc-3458	16	11	referred	refer	VERB
dpc-3458	16	12	to	to	ADP
dpc-3458	16	13	the	the	DET
dpc-3458	16	14	dermatology	dermatology	NOUN
dpc-3458	16	15	department	department	NOUN
dpc-3458	16	16	to	to	PART
dpc-3458	16	17	investigate	investigate	VERB
dpc-3458	16	18	a	a	DET
dpc-3458	16	19	diffuse	diffuse	ADJ
dpc-3458	16	20	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	16	21	of	of	ADP
dpc-3458	16	22	the	the	DET
dpc-3458	16	23	skin	skin	NOUN
dpc-3458	16	24	.	.	PUNCT
dpc-3458	17	1	she	she	PRON
dpc-3458	17	2	reported	report	VERB
dpc-3458	17	3	starting	start	VERB
dpc-3458	17	4	with	with	ADP
dpc-3458	17	5	progressive	progressive	ADJ
dpc-3458	17	6	skin	skin	NOUN
dpc-3458	17	7	darkening	darken	VERB
dpc-3458	17	8	5	5	NUM
dpc-3458	17	9	months	month	NOUN
dpc-3458	17	10	prior	prior	ADV
dpc-3458	17	11	and	and	CCONJ
dpc-3458	17	12	having	have	VERB
dpc-3458	17	13	very	very	ADV
dpc-3458	17	14	dark	dark	ADJ
dpc-3458	17	15	urine	urine	NOUN
dpc-3458	17	16	9	9	NUM
dpc-3458	17	17	months	month	NOUN
dpc-3458	17	18	prior	prior	ADV
dpc-3458	17	19	to	to	ADP
dpc-3458	17	20	her	her	PRON
dpc-3458	17	21	appointment	appointment	NOUN
dpc-3458	17	22	.	.	PUNCT
dpc-3458	18	1	she	she	PRON
dpc-3458	18	2	had	have	VERB
dpc-3458	18	3	a	a	DET
dpc-3458	18	4	diagnosis	diagnosis	NOUN
dpc-3458	18	5	of	of	ADP
dpc-3458	18	6	cutaneous	cutaneous	ADJ
dpc-3458	18	7	melanoma	melanoma	NOUN
dpc-3458	18	8	6	6	NUM
dpc-3458	18	9	years	year	NOUN
dpc-3458	18	10	earlier	early	ADV
dpc-3458	18	11	and	and	CCONJ
dpc-3458	18	12	had	have	AUX
dpc-3458	18	13	discovered	discover	VERB
dpc-3458	18	14	hepatic	hepatic	ADJ
dpc-3458	18	15	metastasis	metastasis	NOUN
dpc-3458	18	16	3	3	NUM
dpc-3458	18	17	years	year	NOUN
dpc-3458	18	18	after	after	ADP
dpc-3458	18	19	the	the	DET
dpc-3458	18	20	melanoma	melanoma	NOUN
dpc-3458	18	21	diagnosis	diagnosis	NOUN
dpc-3458	18	22	.	.	PUNCT
dpc-3458	19	1	upon	upon	SCONJ
dpc-3458	19	2	physical	physical	ADJ
dpc-3458	19	3	examination	examination	NOUN
dpc-3458	19	4	,	,	PUNCT
dpc-3458	19	5	the	the	DET
dpc-3458	19	6	patient	patient	NOUN
dpc-3458	19	7	presented	present	VERB
dpc-3458	19	8	with	with	ADP
dpc-3458	19	9	a	a	DET
dpc-3458	19	10	diffuse	diffuse	ADJ
dpc-3458	19	11	blue	blue	ADJ
dpc-3458	19	12	-	-	PUNCT
dpc-3458	19	13	gray	gray	ADJ
dpc-3458	19	14	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	19	15	,	,	PUNCT
dpc-3458	19	16	which	which	PRON
dpc-3458	19	17	was	be	AUX
dpc-3458	19	18	more	more	ADV
dpc-3458	19	19	accentuated	accentuated	ADJ
dpc-3458	19	20	on	on	ADP
dpc-3458	19	21	the	the	DET
dpc-3458	19	22	face	face	NOUN
dpc-3458	19	23	(	(	PUNCT
dpc-3458	19	24	figure	figure	NOUN
dpc-3458	19	25	1	1	NUM
dpc-3458	19	26	)	)	PUNCT
dpc-3458	19	27	.	.	PUNCT
dpc-3458	20	1	histopathology	histopathology	NOUN
dpc-3458	20	2	and	and	CCONJ
dpc-3458	20	3	fontana	fontana	PROPN
dpc-3458	20	4	–	–	PUNCT
dpc-3458	20	5	masson	masson	PROPN
dpc-3458	20	6	stain	stain	NOUN
dpc-3458	20	7	of	of	ADP
dpc-3458	20	8	the	the	DET
dpc-3458	20	9	skin	skin	NOUN
dpc-3458	20	10	showed	show	VERB
dpc-3458	20	11	melanophages	melanophage	NOUN
dpc-3458	20	12	in	in	ADP
dpc-3458	20	13	a	a	DET
dpc-3458	20	14	superficial	superficial	ADJ
dpc-3458	20	15	perivascular	perivascular	ADJ
dpc-3458	20	16	localization	localization	NOUN
dpc-3458	20	17	,	,	PUNCT
dpc-3458	20	18	compatible	compatible	ADJ
dpc-3458	20	19	with	with	ADP
dpc-3458	20	20	dermic	dermic	ADJ
dpc-3458	20	21	melanosis	melanosis	NOUN
dpc-3458	20	22	(	(	PUNCT
dpc-3458	20	23	figure	figure	NOUN
dpc-3458	20	24	2	2	NUM
dpc-3458	20	25	)	)	PUNCT
dpc-3458	20	26	.	.	PUNCT
dpc-3458	21	1	the	the	DET
dpc-3458	21	2	diagnosis	diagnosis	NOUN
dpc-3458	21	3	of	of	ADP
dpc-3458	21	4	diffuse	diffuse	PROPN
dpc-3458	21	5	melanosis	melanosis	NOUN
dpc-3458	21	6	cutis	cutis	NOUN
dpc-3458	21	7	(	(	PUNCT
dpc-3458	21	8	dmc	dmc	PROPN
dpc-3458	21	9	)	)	PUNCT
dpc-3458	21	10	was	be	AUX
dpc-3458	21	11	established	establish	VERB
dpc-3458	21	12	.	.	PUNCT
dpc-3458	22	1	since	since	SCONJ
dpc-3458	22	2	the	the	DET
dpc-3458	22	3	melanoma	melanoma	NOUN
dpc-3458	22	4	was	be	AUX
dpc-3458	22	5	positive	positive	ADJ
dpc-3458	22	6	for	for	ADP
dpc-3458	22	7	braf	braf	NOUN
dpc-3458	22	8	/	/	SYM
dpc-3458	22	9	v600e	v600e	NOUN
dpc-3458	22	10	mutation	mutation	NOUN
dpc-3458	22	11	with	with	ADP
dpc-3458	22	12	indeterminate	indeterminate	ADJ
dpc-3458	22	13	pdl-1	pdl-1	ADJ
dpc-3458	22	14	expression	expression	NOUN
dpc-3458	22	15	,	,	PUNCT
dpc-3458	22	16	treatment	treatment	NOUN
dpc-3458	22	17	with	with	ADP
dpc-3458	22	18	dabrafenib	dabrafenib	NOUN
dpc-3458	22	19	and	and	CCONJ
dpc-3458	22	20	trametinib	trametinib	NOUN
dpc-3458	22	21	had	have	AUX
dpc-3458	22	22	been	be	AUX
dpc-3458	22	23	instituted	institute	VERB
dpc-3458	22	24	.	.	PUNCT
dpc-3458	23	1	she	she	PRON
dpc-3458	23	2	reported	report	VERB
dpc-3458	23	3	that	that	SCONJ
dpc-3458	23	4	the	the	DET
dpc-3458	23	5	urine	urine	NOUN
dpc-3458	23	6	alterations	alteration	NOUN
dpc-3458	23	7	resolved	resolve	VERB
dpc-3458	23	8	rapidly	rapidly	ADV
dpc-3458	23	9	after	after	ADP
dpc-3458	23	10	initiating	initiate	VERB
dpc-3458	23	11	this	this	DET
dpc-3458	23	12	treatment	treatment	NOUN
dpc-3458	23	13	,	,	PUNCT
dpc-3458	23	14	but	but	CCONJ
dpc-3458	23	15	had	have	VERB
dpc-3458	23	16	little	little	ADJ
dpc-3458	23	17	improvement	improvement	NOUN
dpc-3458	23	18	in	in	ADP
dpc-3458	23	19	skin	skin	NOUN
dpc-3458	23	20	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	23	21	.	.	PUNCT
dpc-3458	24	1	as	as	ADP
dpc-3458	24	2	an	an	DET
dpc-3458	24	3	attempt	attempt	NOUN
dpc-3458	24	4	to	to	PART
dpc-3458	24	5	attenuate	attenuate	VERB
dpc-3458	24	6	the	the	DET
dpc-3458	24	7	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	24	8	,	,	PUNCT
dpc-3458	24	9	we	we	PRON
dpc-3458	24	10	prescribed	prescribe	VERB
dpc-3458	24	11	5	5	NUM
dpc-3458	24	12	%	%	NOUN
dpc-3458	24	13	imiquimod	imiquimod	ADJ
dpc-3458	24	14	for	for	ADP
dpc-3458	24	15	eight	eight	NUM
dpc-3458	24	16	weeks	week	NOUN
dpc-3458	24	17	,	,	PUNCT
dpc-3458	24	18	without	without	ADP
dpc-3458	24	19	any	any	DET
dpc-3458	24	20	improvement	improvement	NOUN
dpc-3458	24	21	.	.	PUNCT
dpc-3458	25	1	we	we	PRON
dpc-3458	25	2	also	also	ADV
dpc-3458	25	3	attempted	attempt	VERB
dpc-3458	25	4	two	two	NUM
dpc-3458	25	5	sessions	session	NOUN
dpc-3458	25	6	of	of	ADP
dpc-3458	25	7	q	q	NOUN
dpc-3458	25	8	-	-	PUNCT
dpc-3458	25	9	switched	switch	VERB
dpc-3458	25	10	laser	laser	NOUN
dpc-3458	25	11	with	with	ADP
dpc-3458	25	12	no	no	DET
dpc-3458	25	13	response	response	NOUN
dpc-3458	25	14	after	after	ADP
dpc-3458	25	15	two	two	NUM
dpc-3458	25	16	sessions	session	NOUN
dpc-3458	25	17	.	.	PUNCT
dpc-3458	26	1	conclusions	conclusion	NOUN
dpc-3458	26	2	the	the	DET
dpc-3458	26	3	exact	exact	ADJ
dpc-3458	26	4	physiopathology	physiopathology	NOUN
dpc-3458	26	5	of	of	ADP
dpc-3458	26	6	dmc	dmc	PROPN
dpc-3458	26	7	is	be	AUX
dpc-3458	26	8	still	still	ADV
dpc-3458	26	9	unclear	unclear	ADJ
dpc-3458	26	10	[	[	X
dpc-3458	26	11	3	3	NUM
dpc-3458	26	12	]	]	PUNCT
dpc-3458	26	13	.	.	PUNCT
dpc-3458	27	1	it	it	PRON
dpc-3458	27	2	is	be	AUX
dpc-3458	27	3	postulated	postulate	VERB
dpc-3458	27	4	that	that	SCONJ
dpc-3458	27	5	metastatic	metastatic	ADJ
dpc-3458	27	6	melanoma	melanoma	NOUN
dpc-3458	27	7	releases	release	VERB
dpc-3458	27	8	melanin	melanin	NOUN
dpc-3458	27	9	precursors	precursor	NOUN
dpc-3458	27	10	in	in	ADP
dpc-3458	27	11	the	the	DET
dpc-3458	27	12	circulation	circulation	NOUN
dpc-3458	27	13	(	(	PUNCT
dpc-3458	27	14	after	after	ADP
dpc-3458	27	15	cytolysis	cytolysis	NOUN
dpc-3458	27	16	as	as	ADP
dpc-3458	27	17	a	a	DET
dpc-3458	27	18	result	result	NOUN
dpc-3458	27	19	of	of	ADP
dpc-3458	27	20	rapid	rapid	ADJ
dpc-3458	27	21	turnover	turnover	NOUN
dpc-3458	27	22	of	of	ADP
dpc-3458	27	23	neoplastic	neoplastic	ADJ
dpc-3458	27	24	deposits	deposit	NOUN
dpc-3458	27	25	,	,	PUNCT
dpc-3458	27	26	central	central	ADJ
dpc-3458	27	27	ischemia	ischemia	NOUN
dpc-3458	27	28	,	,	PUNCT
dpc-3458	27	29	immunological	immunological	ADJ
dpc-3458	27	30	responses	response	NOUN
dpc-3458	27	31	or	or	CCONJ
dpc-3458	27	32	oncologic	oncologic	NOUN
dpc-3458	27	33	therapies	therapy	NOUN
dpc-3458	27	34	)	)	PUNCT
dpc-3458	27	35	,	,	PUNCT
dpc-3458	27	36	which	which	PRON
dpc-3458	27	37	are	be	AUX
dpc-3458	27	38	converted	convert	VERB
dpc-3458	27	39	into	into	ADP
dpc-3458	27	40	melanin	melanin	NOUN
dpc-3458	27	41	in	in	ADP
dpc-3458	27	42	the	the	DET
dpc-3458	27	43	dermis	dermis	NOUN
dpc-3458	27	44	and	and	CCONJ
dpc-3458	27	45	may	may	AUX
dpc-3458	27	46	be	be	AUX
dpc-3458	27	47	phagocytosed	phagocytose	VERB
dpc-3458	27	48	by	by	ADP
dpc-3458	27	49	native	native	ADJ
dpc-3458	27	50	histiocytes	histiocyte	NOUN
dpc-3458	27	51	,	,	PUNCT
dpc-3458	27	52	causing	cause	VERB
dpc-3458	27	53	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	27	54	[	[	X
dpc-3458	27	55	2	2	NUM
dpc-3458	27	56	]	]	PUNCT
dpc-3458	27	57	.	.	PUNCT
dpc-3458	28	1	melanin	melanin	NOUN
dpc-3458	28	2	precursors	precursor	NOUN
dpc-3458	28	3	can	can	AUX
dpc-3458	28	4	also	also	ADV
dpc-3458	28	5	be	be	AUX
dpc-3458	28	6	excreted	excrete	VERB
dpc-3458	28	7	in	in	ADP
dpc-3458	28	8	urine	urine	NOUN
dpc-3458	28	9	causing	cause	VERB
dpc-3458	28	10	melanuria	melanuria	NOUN
dpc-3458	29	1	[	[	X
dpc-3458	29	2	2	2	NUM
dpc-3458	29	3	]	]	PUNCT
dpc-3458	29	4	.	.	PUNCT
dpc-3458	30	1	other	other	ADJ
dpc-3458	30	2	theories	theory	NOUN
dpc-3458	30	3	include	include	VERB
dpc-3458	30	4	the	the	DET
dpc-3458	30	5	possibility	possibility	NOUN
dpc-3458	30	6	that	that	SCONJ
dpc-3458	30	7	2	2	NUM
dpc-3458	30	8	research	research	NOUN
dpc-3458	30	9	letter	letter	NOUN
dpc-3458	30	10	|	|	ADV
dpc-3458	30	11	dermatol	dermatol	ADJ
dpc-3458	30	12	pract	pract	NOUN
dpc-3458	30	13	concept	concept	NOUN
dpc-3458	30	14	.	.	PUNCT
dpc-3458	31	1	2024;14(1):e2024020	2024;14(1):e2024020	NUM
dpc-3458	31	2	melanocyte	melanocyte	NOUN
dpc-3458	31	3	proliferation	proliferation	NOUN
dpc-3458	31	4	might	might	AUX
dpc-3458	31	5	be	be	AUX
dpc-3458	31	6	stimulated	stimulate	VERB
dpc-3458	31	7	by	by	ADP
dpc-3458	31	8	growth	growth	NOUN
dpc-3458	31	9	factors	factor	NOUN
dpc-3458	31	10	released	release	VERB
dpc-3458	31	11	by	by	ADP
dpc-3458	31	12	cancer	cancer	NOUN
dpc-3458	31	13	cells	cell	NOUN
dpc-3458	31	14	or	or	CCONJ
dpc-3458	31	15	that	that	SCONJ
dpc-3458	31	16	dmc	dmc	PROPN
dpc-3458	31	17	may	may	AUX
dpc-3458	31	18	be	be	AUX
dpc-3458	31	19	caused	cause	VERB
dpc-3458	31	20	by	by	ADP
dpc-3458	31	21	dermal	dermal	ADJ
dpc-3458	31	22	micrometastasis	micrometastasis	NOUN
dpc-3458	31	23	producing	produce	VERB
dpc-3458	31	24	melanin	melanin	NOUN
dpc-3458	32	1	[	[	X
dpc-3458	32	2	4	4	NUM
dpc-3458	32	3	]	]	PUNCT
dpc-3458	32	4	.	.	PUNCT
dpc-3458	33	1	furthermore	furthermore	ADV
dpc-3458	33	2	,	,	PUNCT
dpc-3458	33	3	more	more	ADJ
dpc-3458	33	4	than	than	ADP
dpc-3458	33	5	one	one	NUM
dpc-3458	33	6	pathway	pathway	NOUN
dpc-3458	33	7	may	may	AUX
dpc-3458	33	8	contribute	contribute	VERB
dpc-3458	33	9	to	to	ADP
dpc-3458	33	10	the	the	DET
dpc-3458	33	11	etiopathogenesis	etiopathogenesis	NOUN
dpc-3458	33	12	of	of	ADP
dpc-3458	33	13	dmc	dmc	PROPN
dpc-3458	33	14	.	.	PROPN
dpc-3458	33	15	pigmentation	pigmentation	NOUN
dpc-3458	33	16	is	be	AUX
dpc-3458	33	17	most	most	ADV
dpc-3458	33	18	frequently	frequently	ADV
dpc-3458	33	19	seen	see	VERB
dpc-3458	33	20	in	in	ADP
dpc-3458	33	21	a	a	DET
dpc-3458	33	22	photo	photo	NOUN
dpc-3458	33	23	-	-	PUNCT
dpc-3458	33	24	distributed	distribute	VERB
dpc-3458	33	25	pattern	pattern	NOUN
dpc-3458	33	26	[	[	X
dpc-3458	33	27	5	5	NUM
dpc-3458	33	28	]	]	PUNCT
dpc-3458	33	29	.	.	PUNCT
dpc-3458	34	1	histologic	histologic	PROPN
dpc-3458	34	2	findings	finding	NOUN
dpc-3458	34	3	include	include	VERB
dpc-3458	34	4	increased	increase	VERB
dpc-3458	34	5	melanin	melanin	NOUN
dpc-3458	34	6	in	in	ADP
dpc-3458	34	7	dermal	dermal	ADJ
dpc-3458	34	8	histiocytes	histiocyte	NOUN
dpc-3458	34	9	,	,	PUNCT
dpc-3458	34	10	free	free	ADJ
dpc-3458	34	11	pigment	pigment	NOUN
dpc-3458	34	12	between	between	ADP
dpc-3458	34	13	collagen	collagen	NOUN
dpc-3458	34	14	stroma	stroma	NOUN
dpc-3458	34	15	and	and	CCONJ
dpc-3458	34	16	epidermal	epidermal	ADJ
dpc-3458	34	17	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	34	18	  	  	SPACE
dpc-3458	34	19	[	[	X
dpc-3458	34	20	2	2	NUM
dpc-3458	34	21	]	]	PUNCT
dpc-3458	34	22	.	.	PUNCT
dpc-3458	35	1	melanophages	melanophage	NOUN
dpc-3458	35	2	extending	extend	VERB
dpc-3458	35	3	to	to	ADP
dpc-3458	35	4	subcutis	subcutis	NOUN
dpc-3458	35	5	and	and	CCONJ
dpc-3458	35	6	skeletal	skeletal	ADJ
dpc-3458	35	7	muscle	muscle	NOUN
dpc-3458	35	8	can	can	AUX
dpc-3458	35	9	also	also	ADV
dpc-3458	35	10	be	be	AUX
dpc-3458	35	11	seen	see	VERB
dpc-3458	35	12	[	[	PUNCT
dpc-3458	35	13	6	6	NUM
dpc-3458	35	14	]	]	PUNCT
dpc-3458	35	15	.	.	PUNCT
dpc-3458	36	1	there	there	PRON
dpc-3458	36	2	is	be	VERB
dpc-3458	36	3	no	no	DET
dpc-3458	36	4	treatment	treatment	NOUN
dpc-3458	36	5	for	for	ADP
dpc-3458	36	6	dmc	dmc	NOUN
dpc-3458	36	7	.	.	PUNCT
dpc-3458	37	1	successful	successful	ADJ
dpc-3458	37	2	treatment	treatment	NOUN
dpc-3458	37	3	of	of	ADP
dpc-3458	37	4	localized	localized	ADJ
dpc-3458	37	5	melanosis	melanosis	NOUN
dpc-3458	37	6	cutis	cutis	NOUN
dpc-3458	37	7	with	with	ADP
dpc-3458	37	8	imiquimod	imiquimod	ADJ
dpc-3458	37	9	cream	cream	NOUN
dpc-3458	37	10	5	5	NUM
dpc-3458	37	11	%	%	NOUN
dpc-3458	37	12	has	have	AUX
dpc-3458	37	13	been	be	AUX
dpc-3458	37	14	described	describe	VERB
dpc-3458	37	15	[	[	X
dpc-3458	37	16	5	5	NUM
dpc-3458	37	17	]	]	PUNCT
dpc-3458	37	18	,	,	PUNCT
dpc-3458	37	19	although	although	SCONJ
dpc-3458	37	20	our	our	PRON
dpc-3458	37	21	patient	patient	NOUN
dpc-3458	37	22	did	do	AUX
dpc-3458	37	23	not	not	PART
dpc-3458	37	24	present	present	VERB
dpc-3458	37	25	with	with	ADP
dpc-3458	37	26	the	the	DET
dpc-3458	37	27	same	same	ADJ
dpc-3458	37	28	outcome	outcome	NOUN
dpc-3458	37	29	.	.	PUNCT
dpc-3458	38	1	dmc	dmc	PROPN
dpc-3458	38	2	is	be	AUX
dpc-3458	38	3	a	a	DET
dpc-3458	38	4	bad	bad	ADJ
dpc-3458	38	5	prognosis	prognosis	NOUN
dpc-3458	38	6	marker	marker	NOUN
dpc-3458	38	7	,	,	PUNCT
dpc-3458	38	8	with	with	ADP
dpc-3458	38	9	a	a	DET
dpc-3458	38	10	mean	mean	ADJ
dpc-3458	38	11	life	life	NOUN
dpc-3458	38	12	expectancy	expectancy	NOUN
dpc-3458	38	13	after	after	ADP
dpc-3458	38	14	developing	develop	VERB
dpc-3458	38	15	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	38	16	of	of	ADP
dpc-3458	38	17	4	4	NUM
dpc-3458	38	18	to	to	PART
dpc-3458	38	19	5	5	NUM
dpc-3458	38	20	months	month	NOUN
dpc-3458	38	21	[	[	X
dpc-3458	38	22	2	2	NUM
dpc-3458	38	23	]	]	PUNCT
dpc-3458	38	24	.	.	PUNCT
dpc-3458	39	1	it	it	PRON
dpc-3458	39	2	is	be	AUX
dpc-3458	39	3	a	a	DET
dpc-3458	39	4	presentation	presentation	NOUN
dpc-3458	39	5	of	of	ADP
dpc-3458	39	6	metastatic	metastatic	ADJ
dpc-3458	39	7	melanoma	melanoma	NOUN
dpc-3458	39	8	,	,	PUNCT
dpc-3458	39	9	considered	consider	VERB
dpc-3458	39	10	by	by	ADP
dpc-3458	39	11	some	some	DET
dpc-3458	39	12	authors	author	NOUN
dpc-3458	39	13	as	as	ADP
dpc-3458	39	14	a	a	DET
dpc-3458	39	15	paraneoplastic	paraneoplastic	ADJ
dpc-3458	39	16	condition	condition	NOUN
dpc-3458	39	17	,	,	PUNCT
dpc-3458	39	18	that	that	PRON
dpc-3458	39	19	can	can	AUX
dpc-3458	39	20	assist	assist	VERB
dpc-3458	39	21	in	in	ADP
dpc-3458	39	22	the	the	DET
dpc-3458	39	23	diagnosis	diagnosis	NOUN
dpc-3458	39	24	of	of	ADP
dpc-3458	39	25	advanced	advanced	ADJ
dpc-3458	39	26	melanoma	melanoma	NOUN
dpc-3458	39	27	[	[	X
dpc-3458	39	28	4	4	NUM
dpc-3458	39	29	]	]	PUNCT
dpc-3458	39	30	.	.	PUNCT
dpc-3458	40	1	braf	braf	PROPN
dpc-3458	40	2	-	-	PUNCT
dpc-3458	40	3	mek	mek	PROPN
dpc-3458	40	4	inhibitors	inhibitor	NOUN
dpc-3458	40	5	have	have	AUX
dpc-3458	40	6	significantly	significantly	ADV
dpc-3458	40	7	expanded	expand	VERB
dpc-3458	40	8	life	life	NOUN
dpc-3458	40	9	-	-	PUNCT
dpc-3458	40	10	expectancy	expectancy	NOUN
dpc-3458	40	11	in	in	ADP
dpc-3458	40	12	metastatic	metastatic	ADJ
dpc-3458	40	13	melanoma	melanoma	NOUN
dpc-3458	40	14	.	.	PUNCT
dpc-3458	41	1	our	our	PRON
dpc-3458	41	2	patient	patient	NOUN
dpc-3458	41	3	died	die	VERB
dpc-3458	41	4	24	24	NUM
dpc-3458	41	5	months	month	NOUN
dpc-3458	41	6	after	after	ADP
dpc-3458	41	7	first	first	ADV
dpc-3458	41	8	developing	develop	VERB
dpc-3458	41	9	dmc	dmc	PROPN
dpc-3458	41	10	.	.	PUNCT
dpc-3458	42	1	interestingly	interestingly	ADV
dpc-3458	42	2	,	,	PUNCT
dpc-3458	42	3	as	as	SCONJ
dpc-3458	42	4	previously	previously	ADV
dpc-3458	42	5	reported	report	VERB
dpc-3458	42	6	,	,	PUNCT
dpc-3458	42	7	our	our	PRON
dpc-3458	42	8	patient	patient	ADJ
dpc-3458	42	9	melanuria	melanuria	NOUN
dpc-3458	42	10	completely	completely	ADV
dpc-3458	42	11	resolved	resolve	VERB
dpc-3458	42	12	after	after	ADP
dpc-3458	42	13	initiating	initiate	VERB
dpc-3458	42	14	treatment	treatment	NOUN
dpc-3458	42	15	with	with	ADP
dpc-3458	42	16	dabrafenib	dabrafenib	NOUN
dpc-3458	42	17	and	and	CCONJ
dpc-3458	42	18	trametinib	trametinib	NOUN
dpc-3458	42	19	,	,	PUNCT
dpc-3458	42	20	although	although	SCONJ
dpc-3458	42	21	no	no	DET
dpc-3458	42	22	improvement	improvement	NOUN
dpc-3458	42	23	in	in	ADP
dpc-3458	42	24	skin	skin	NOUN
dpc-3458	42	25	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	42	26	was	be	AUX
dpc-3458	42	27	seen	see	VERB
dpc-3458	42	28	[	[	X
dpc-3458	42	29	1	1	NUM
dpc-3458	42	30	]	]	PUNCT
dpc-3458	42	31	.	.	PUNCT
dpc-3458	43	1	even	even	ADV
dpc-3458	43	2	though	though	SCONJ
dpc-3458	43	3	our	our	PRON
dpc-3458	43	4	attempts	attempt	NOUN
dpc-3458	43	5	to	to	PART
dpc-3458	43	6	treat	treat	VERB
dpc-3458	43	7	dmc	dmc	PROPN
dpc-3458	43	8	were	be	AUX
dpc-3458	43	9	not	not	PART
dpc-3458	43	10	successful	successful	ADJ
dpc-3458	43	11	,	,	PUNCT
dpc-3458	43	12	we	we	PRON
dpc-3458	43	13	believe	believe	VERB
dpc-3458	43	14	this	this	PRON
dpc-3458	43	15	is	be	AUX
dpc-3458	43	16	a	a	DET
dpc-3458	43	17	field	field	NOUN
dpc-3458	43	18	which	which	PRON
dpc-3458	43	19	ought	ought	AUX
dpc-3458	43	20	to	to	PART
dpc-3458	43	21	be	be	AUX
dpc-3458	43	22	studied	study	VERB
dpc-3458	43	23	further	far	ADV
dpc-3458	43	24	.	.	PUNCT
dpc-3458	44	1	the	the	DET
dpc-3458	44	2	cosmetic	cosmetic	ADJ
dpc-3458	44	3	impact	impact	NOUN
dpc-3458	44	4	of	of	ADP
dpc-3458	44	5	dmc	dmc	NOUN
dpc-3458	44	6	on	on	ADP
dpc-3458	44	7	patients	patient	NOUN
dpc-3458	44	8	has	have	AUX
dpc-3458	44	9	not	not	PART
dpc-3458	44	10	been	be	AUX
dpc-3458	44	11	explored	explore	VERB
dpc-3458	44	12	as	as	SCONJ
dpc-3458	44	13	it	it	PRON
dpc-3458	44	14	was	be	AUX
dpc-3458	44	15	associated	associate	VERB
dpc-3458	44	16	with	with	ADP
dpc-3458	44	17	a	a	DET
dpc-3458	44	18	very	very	ADV
dpc-3458	44	19	poor	poor	ADJ
dpc-3458	44	20	prognosis	prognosis	NOUN
dpc-3458	44	21	.	.	PUNCT
dpc-3458	45	1	however	however	ADV
dpc-3458	45	2	,	,	PUNCT
dpc-3458	45	3	since	since	SCONJ
dpc-3458	45	4	the	the	DET
dpc-3458	45	5	advent	advent	NOUN
dpc-3458	45	6	of	of	ADP
dpc-3458	45	7	targeted	target	VERB
dpc-3458	45	8	therapy	therapy	NOUN
dpc-3458	45	9	and	and	CCONJ
dpc-3458	45	10	figure	figure	NOUN
dpc-3458	45	11	1	1	NUM
dpc-3458	45	12	.	.	PUNCT
dpc-3458	46	1	diffuse	diffuse	VERB
dpc-3458	46	2	blue	blue	ADJ
dpc-3458	46	3	-	-	PUNCT
dpc-3458	46	4	gray	gray	ADJ
dpc-3458	46	5	hyperpigmentation	hyperpigmentation	NOUN
dpc-3458	46	6	,	,	PUNCT
dpc-3458	46	7	more	more	ADV
dpc-3458	46	8	accentuated	accentuated	ADJ
dpc-3458	46	9	on	on	ADP
dpc-3458	46	10	the	the	DET
dpc-3458	46	11	face	face	NOUN
dpc-3458	46	12	.	.	PUNCT
dpc-3458	47	1	figure	figure	NOUN
dpc-3458	47	2	2	2	NUM
dpc-3458	47	3	.	.	PUNCT
dpc-3458	47	4	histopathology	histopathology	NOUN
dpc-3458	47	5	(	(	PUNCT
dpc-3458	47	6	h&e	h&e	PROPN
dpc-3458	47	7	and	and	CCONJ
dpc-3458	47	8	fontana	fontana	PROPN
dpc-3458	47	9	–	–	PUNCT
dpc-3458	47	10	masson	masson	PROPN
dpc-3458	47	11	stains	stains	PROPN
dpc-3458	47	12	)	)	PUNCT
dpc-3458	47	13	showing	show	VERB
dpc-3458	47	14	melanin	melanin	NOUN
dpc-3458	47	15	deposition	deposition	NOUN
dpc-3458	47	16	in	in	ADP
dpc-3458	47	17	the	the	DET
dpc-3458	47	18	superficial	superficial	ADJ
dpc-3458	47	19	dermis	dermis	NOUN
dpc-3458	47	20	with	with	ADP
dpc-3458	47	21	a	a	DET
dpc-3458	47	22	perivascular	perivascular	ADJ
dpc-3458	47	23	distribution	distribution	NOUN
dpc-3458	47	24	.	.	PUNCT
dpc-3458	48	1	research	research	NOUN
dpc-3458	48	2	letter	letter	NOUN
dpc-3458	48	3	|	|	ADV
dpc-3458	48	4	dermatol	dermatol	ADJ
dpc-3458	48	5	pract	pract	NOUN
dpc-3458	48	6	concept	concept	NOUN
dpc-3458	48	7	.	.	PUNCT
dpc-3458	49	1	2024;14(1):e2024020	2024;14(1):e2024020	NUM
dpc-3458	49	2	3	3	NUM
dpc-3458	49	3	immunotherapy	immunotherapy	NOUN
dpc-3458	49	4	,	,	PUNCT
dpc-3458	49	5	these	these	DET
dpc-3458	49	6	patients	patient	NOUN
dpc-3458	49	7	are	be	AUX
dpc-3458	49	8	living	live	VERB
dpc-3458	49	9	longer	long	ADV
dpc-3458	49	10	,	,	PUNCT
dpc-3458	49	11	so	so	SCONJ
dpc-3458	49	12	treatments	treatment	NOUN
dpc-3458	49	13	for	for	ADP
dpc-3458	49	14	melanosis	melanosis	NOUN
dpc-3458	49	15	might	might	AUX
dpc-3458	49	16	improve	improve	VERB
dpc-3458	49	17	their	their	PRON
dpc-3458	49	18	quality	quality	NOUN
dpc-3458	49	19	of	of	ADP
dpc-3458	49	20	life	life	NOUN
dpc-3458	49	21	.	.	PUNCT
dpc-3458	50	1	references	reference	NOUN
dpc-3458	50	2	1	1	NUM
dpc-3458	50	3	.	.	PUNCT
dpc-3458	50	4	minocha	minocha	PROPN
dpc-3458	50	5	r	r	PROPN
dpc-3458	50	6	,	,	PUNCT
dpc-3458	50	7	kefford	kefford	NOUN
dpc-3458	50	8	r	r	PROPN
dpc-3458	50	9	,	,	PUNCT
dpc-3458	50	10	uribe	uribe	PROPN
dpc-3458	50	11	p	p	PROPN
dpc-3458	50	12	,	,	PUNCT
dpc-3458	50	13	et	et	PROPN
dpc-3458	50	14	al	al	PROPN
dpc-3458	50	15	.	.	PUNCT
dpc-3458	51	1	diffuse	diffuse	PROPN
dpc-3458	51	2	melanosis	melanosis	PROPN
dpc-3458	51	3	cutis	cutis	NOUN
dpc-3458	51	4	in	in	ADP
dpc-3458	51	5	the	the	DET
dpc-3458	51	6	setting	setting	NOUN
dpc-3458	51	7	of	of	ADP
dpc-3458	51	8	braf	braf	NOUN
dpc-3458	51	9	v600e	v600e	PUNCT
dpc-3458	51	10	mutant	mutant	ADJ
dpc-3458	51	11	melanoma	melanoma	NOUN
dpc-3458	51	12	and	and	CCONJ
dpc-3458	51	13	treatment	treatment	NOUN
dpc-3458	51	14	with	with	ADP
dpc-3458	51	15	targeted	target	VERB
dpc-3458	51	16	therapies	therapy	NOUN
dpc-3458	51	17	:	:	PUNCT
dpc-3458	51	18	dmc	dmc	PROPN
dpc-3458	51	19	treated	treat	VERB
dpc-3458	51	20	with	with	ADP
dpc-3458	51	21	targeted	target	VERB
dpc-3458	51	22	therapies	therapy	NOUN
dpc-3458	51	23	.	.	PUNCT
dpc-3458	52	1	australas	australas	PROPN
dpc-3458	52	2	j	j	PROPN
dpc-3458	52	3	dermatol	dermatol	NOUN
dpc-3458	52	4	.	.	PUNCT
dpc-3458	53	1	2015;56(2):128–130	2015;56(2):128–130	NOUN
dpc-3458	53	2	.	.	PUNCT
dpc-3458	53	3	doi	doi	NOUN
dpc-3458	53	4	:	:	PUNCT
dpc-3458	53	5	10.1111	10.1111	NUM
dpc-3458	53	6	/ajd.12187	/ajd.12187	NOUN
dpc-3458	53	7	.	.	PUNCT
dpc-3458	54	1	pmid	pmid	NOUN
dpc-3458	54	2	:	:	PUNCT
dpc-3458	54	3	25159853	25159853	NUM
dpc-3458	54	4	.	.	PUNCT
dpc-3458	55	1	2	2	X
dpc-3458	55	2	.	.	X
dpc-3458	55	3	sebaratnam	sebaratnam	PROPN
dpc-3458	55	4	df	df	PROPN
dpc-3458	55	5	,	,	PUNCT
dpc-3458	55	6	venugopal	venugopal	PROPN
dpc-3458	55	7	ss	ss	PROPN
dpc-3458	55	8	,	,	PUNCT
dpc-3458	55	9	frew	frew	PROPN
dpc-3458	55	10	jw	jw	PROPN
dpc-3458	55	11	,	,	PUNCT
dpc-3458	55	12	et	et	PROPN
dpc-3458	55	13	al	al	PROPN
dpc-3458	55	14	.	.	PUNCT
dpc-3458	56	1	diffuse	diffuse	PROPN
dpc-3458	56	2	melanosis	melanosis	PROPN
dpc-3458	56	3	cutis	cutis	NOUN
dpc-3458	56	4	:	:	PUNCT
dpc-3458	56	5	a	a	DET
dpc-3458	56	6	systematic	systematic	ADJ
dpc-3458	56	7	review	review	NOUN
dpc-3458	56	8	of	of	ADP
dpc-3458	56	9	the	the	DET
dpc-3458	56	10	literature	literature	NOUN
dpc-3458	56	11	.	.	PUNCT
dpc-3458	57	1	j	j	PROPN
dpc-3458	57	2	am	be	AUX
dpc-3458	57	3	acad	acad	ADJ
dpc-3458	57	4	dermatol	dermatol	NOUN
dpc-3458	57	5	.	.	PUNCT
dpc-3458	58	1	2013;68(3):482	2013;68(3):482	NUM
dpc-3458	58	2	-	-	SYM
dpc-3458	58	3	488	488	NUM
dpc-3458	58	4	.	.	PUNCT
dpc-3458	59	1	doi	doi	NOUN
dpc-3458	59	2	:	:	PUNCT
dpc-3458	59	3	10.1016	10.1016	NUM
dpc-3458	59	4	/	/	SYM
dpc-3458	59	5	j.jaad.2012.08.018	j.jaad.2012.08.018	PROPN
dpc-3458	59	6	.	.	PUNCT
dpc-3458	60	1	pmid	pmid	NOUN
dpc-3458	60	2	:	:	PUNCT
dpc-3458	60	3	23219556	23219556	NUM
dpc-3458	60	4	.	.	PUNCT
dpc-3458	61	1	3	3	X
dpc-3458	61	2	.	.	X
dpc-3458	61	3	piana	piana	PROPN
dpc-3458	61	4	s	s	PROPN
dpc-3458	61	5	,	,	PUNCT
dpc-3458	61	6	longo	longo	PROPN
dpc-3458	61	7	c.	c.	PROPN
dpc-3458	61	8	diffuse	diffuse	PROPN
dpc-3458	61	9	melanosis	melanosis	NOUN
dpc-3458	61	10	and	and	CCONJ
dpc-3458	61	11	melanuria	melanuria	NOUN
dpc-3458	61	12	.	.	PUNCT
dpc-3458	62	1	n	n	PROPN
dpc-3458	62	2	engl	engl	PROPN
dpc-3458	62	3	j	j	PROPN
dpc-3458	62	4	med	med	PROPN
dpc-3458	62	5	.	.	PUNCT
dpc-3458	63	1	2019;380(12):1166	2019;380(12):1166	NUM
dpc-3458	63	2	.	.	PUNCT
dpc-3458	63	3	doi	doi	NOUN
dpc-3458	63	4	:	:	PUNCT
dpc-3458	63	5	10.1056	10.1056	NUM
dpc-3458	63	6	/	/	SYM
dpc-3458	63	7	nejmicm1810151	nejmicm1810151	PROPN
dpc-3458	63	8	.	.	PUNCT
dpc-3458	64	1	pmid	pmid	NOUN
dpc-3458	64	2	:	:	PUNCT
dpc-3458	64	3	30893538	30893538	NUM
dpc-3458	64	4	.	.	PUNCT
dpc-3458	65	1	4	4	X
dpc-3458	65	2	.	.	X
dpc-3458	65	3	chinai	chinai	PROPN
dpc-3458	65	4	b	b	NOUN
dpc-3458	65	5	,	,	PUNCT
dpc-3458	65	6	piazza	piazza	NOUN
dpc-3458	65	7	m	m	PROPN
dpc-3458	65	8	,	,	PUNCT
dpc-3458	65	9	patel	patel	PROPN
dpc-3458	65	10	r	r	PROPN
dpc-3458	65	11	,	,	PUNCT
dpc-3458	65	12	roy	roy	PROPN
dpc-3458	65	13	s.	s.	PROPN
dpc-3458	65	14	diffuse	diffuse	PROPN
dpc-3458	65	15	melanosis	melanosis	PROPN
dpc-3458	65	16	cutis	cutis	NOUN
dpc-3458	65	17	:	:	PUNCT
dpc-3458	65	18	a	a	DET
dpc-3458	65	19	rare	rare	ADJ
dpc-3458	65	20	manifestation	manifestation	NOUN
dpc-3458	65	21	of	of	ADP
dpc-3458	65	22	metastatic	metastatic	ADJ
dpc-3458	65	23	melanoma	melanoma	NOUN
dpc-3458	65	24	.	.	PUNCT
dpc-3458	66	1	bmj	bmj	PROPN
dpc-3458	66	2	case	case	NOUN
dpc-3458	66	3	rep	rep	PROPN
dpc-3458	66	4	.	.	PROPN
dpc-3458	66	5	2019;12(8):e230396	2019;12(8):e230396	NUM
dpc-3458	66	6	.	.	PUNCT
dpc-3458	66	7	doi	doi	NOUN
dpc-3458	66	8	:	:	PUNCT
dpc-3458	66	9	10.1136	10.1136	NUM
dpc-3458	66	10	/	/	SYM
dpc-3458	66	11	bcr-2019	bcr-2019	NOUN
dpc-3458	66	12	-	-	PUNCT
dpc-3458	66	13	230396	230396	NUM
dpc-3458	66	14	.	.	PUNCT
dpc-3458	67	1	pmid	pmid	NOUN
dpc-3458	67	2	:	:	PUNCT
dpc-3458	67	3	31473636	31473636	NUM
dpc-3458	67	4	.	.	PUNCT
dpc-3458	68	1	pmcid	pmcid	NOUN
dpc-3458	68	2	:	:	PUNCT
dpc-3458	68	3	pmc6720706	pmc6720706	PROPN
dpc-3458	68	4	.	.	PUNCT
dpc-3458	69	1	5	5	X
dpc-3458	69	2	.	.	X
dpc-3458	69	3	fields	field	NOUN
dpc-3458	69	4	k	k	PROPN
dpc-3458	69	5	,	,	PUNCT
dpc-3458	69	6	milikowski	milikowski	NOUN
dpc-3458	69	7	c	c	PROPN
dpc-3458	69	8	,	,	PUNCT
dpc-3458	69	9	jewell	jewell	PROPN
dpc-3458	69	10	t	t	PROPN
dpc-3458	69	11	,	,	PUNCT
dpc-3458	69	12	fields	fields	PROPN
dpc-3458	69	13	j.	j.	PROPN
dpc-3458	69	14	localized	localize	VERB
dpc-3458	69	15	diffuse	diffuse	PROPN
dpc-3458	69	16	melanosis	melanosis	NOUN
dpc-3458	69	17	associated	associate	VERB
dpc-3458	69	18	with	with	ADP
dpc-3458	69	19	melanoma	melanoma	NOUN
dpc-3458	69	20	successfully	successfully	ADV
dpc-3458	69	21	treated	treat	VERB
dpc-3458	69	22	with	with	ADP
dpc-3458	69	23	imiquimod	imiquimod	ADJ
dpc-3458	69	24	cream	cream	NOUN
dpc-3458	69	25	5	5	NUM
dpc-3458	69	26	%	%	NOUN
dpc-3458	69	27	:	:	PUNCT
dpc-3458	69	28	a	a	DET
dpc-3458	69	29	case	case	NOUN
dpc-3458	69	30	report	report	NOUN
dpc-3458	69	31	and	and	CCONJ
dpc-3458	69	32	review	review	NOUN
dpc-3458	69	33	of	of	ADP
dpc-3458	69	34	the	the	DET
dpc-3458	69	35	literature	literature	NOUN
dpc-3458	69	36	.	.	PUNCT
dpc-3458	70	1	cutis	cutis	NOUN
dpc-3458	70	2	.	.	PUNCT
dpc-3458	71	1	2014;93(3):145–150	2014;93(3):145–150	NUM
dpc-3458	71	2	.	.	PUNCT
dpc-3458	72	1	pmid	pmid	NOUN
dpc-3458	72	2	:	:	PUNCT
dpc-3458	72	3	24738096	24738096	NUM
dpc-3458	72	4	.	.	PUNCT
dpc-3458	73	1	6	6	X
dpc-3458	73	2	.	.	X
dpc-3458	73	3	sebaratnam	sebaratnam	PROPN
dpc-3458	73	4	df	df	PROPN
dpc-3458	73	5	,	,	PUNCT
dpc-3458	73	6	martin	martin	PROPN
dpc-3458	73	7	lk	lk	PROPN
dpc-3458	73	8	,	,	PUNCT
dpc-3458	73	9	venugopal	venugopal	PROPN
dpc-3458	73	10	ss	ss	PROPN
dpc-3458	73	11	,	,	PUNCT
dpc-3458	73	12	et	et	PROPN
dpc-3458	73	13	al	al	PROPN
dpc-3458	73	14	.	.	PUNCT
dpc-3458	74	1	diffuse	diffuse	PROPN
dpc-3458	74	2	melanosis	melanosis	PROPN
dpc-3458	74	3	cutis	cutis	NOUN
dpc-3458	74	4	in	in	ADP
dpc-3458	74	5	the	the	DET
dpc-3458	74	6	setting	setting	NOUN
dpc-3458	74	7	of	of	ADP
dpc-3458	74	8	braf(v600e	braf(v600e	NOUN
dpc-3458	74	9	)	)	PUNCT
dpc-3458	74	10	metastatic	metastatic	ADJ
dpc-3458	74	11	melanoma	melanoma	NOUN
dpc-3458	74	12	.	.	PUNCT
dpc-3458	75	1	int	int	NOUN
dpc-3458	75	2	j	j	PROPN
dpc-3458	75	3	dermatol	dermatol	NOUN
dpc-3458	75	4	.	.	PUNCT
dpc-3458	76	1	2014;53(11):1409–1411	2014;53(11):1409–1411	NUM
dpc-3458	76	2	.	.	PUNCT
dpc-3458	77	1	doi	doi	NOUN
dpc-3458	77	2	:	:	PUNCT
dpc-3458	77	3	10.1111	10.1111	NUM
dpc-3458	77	4	/	/	SYM
dpc-3458	77	5	ijd.12614	ijd.12614	NUM
dpc-3458	77	6	.	.	PUNCT
dpc-3458	78	1	pmid	pmid	NOUN
dpc-3458	78	2	:	:	PUNCT
dpc-3458	78	3	25257244	25257244	NUM
dpc-3458	78	4	.	.	PUNCT