id	sid	tid	token	lemma	pos
dpc-3965	1	1	dermatology	dermatology	NOUN
dpc-3965	1	2	:	:	PUNCT
dpc-3965	1	3	practical	practical	ADJ
dpc-3965	1	4	and	and	CCONJ
dpc-3965	1	5	conceptual	conceptual	ADJ
dpc-3965	1	6	review	review	NOUN
dpc-3965	1	7	|	|	ADV
dpc-3965	1	8	dermatol	dermatol	ADJ
dpc-3965	1	9	pract	pract	NOUN
dpc-3965	1	10	concept	concept	NOUN
dpc-3965	1	11	.	.	PUNCT
dpc-3965	2	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	2	2	1	1	NUM
dpc-3965	2	3	therapeutic	therapeutic	ADJ
dpc-3965	2	4	promise	promise	NOUN
dpc-3965	2	5	of	of	ADP
dpc-3965	2	6	hyaluronidase	hyaluronidase	NOUN
dpc-3965	2	7	in	in	ADP
dpc-3965	2	8	systemic	systemic	ADJ
dpc-3965	2	9	sclerosis	sclerosis	NOUN
dpc-3965	2	10	:	:	PUNCT
dpc-3965	2	11	a	a	DET
dpc-3965	2	12	systematic	systematic	ADJ
dpc-3965	2	13	review	review	NOUN
dpc-3965	2	14	anika	anika	NOUN
dpc-3965	2	15	pulumati1	pulumati1	NOUN
dpc-3965	2	16	,	,	PUNCT
dpc-3965	2	17	rachel	rachel	PROPN
dpc-3965	2	18	lin1	lin1	PROPN
dpc-3965	2	19	,	,	PUNCT
dpc-3965	2	20	scott	scott	PROPN
dpc-3965	2	21	a.	a.	PROPN
dpc-3965	2	22	elman1	elman1	PROPN
dpc-3965	3	1	1	1	NUM
dpc-3965	3	2	university	university	PROPN
dpc-3965	3	3	of	of	ADP
dpc-3965	3	4	miami	miami	PROPN
dpc-3965	3	5	dr	dr	PROPN
dpc-3965	3	6	.	.	PROPN
dpc-3965	3	7	phillip	phillip	PROPN
dpc-3965	3	8	frost	frost	PROPN
dpc-3965	3	9	department	department	PROPN
dpc-3965	3	10	of	of	ADP
dpc-3965	3	11	dermatology	dermatology	NOUN
dpc-3965	3	12	and	and	CCONJ
dpc-3965	3	13	cutaneous	cutaneous	ADJ
dpc-3965	3	14	surgery	surgery	NOUN
dpc-3965	3	15	,	,	PUNCT
dpc-3965	3	16	miami	miami	PROPN
dpc-3965	3	17	,	,	PUNCT
dpc-3965	3	18	fl	fl	PROPN
dpc-3965	3	19	,	,	PUNCT
dpc-3965	3	20	usa	usa	PROPN
dpc-3965	3	21	key	key	NOUN
dpc-3965	3	22	words	word	NOUN
dpc-3965	3	23	:	:	PUNCT
dpc-3965	3	24	scleroderma	scleroderma	NOUN
dpc-3965	3	25	,	,	PUNCT
dpc-3965	3	26	systemic	systemic	ADJ
dpc-3965	3	27	sclerosis	sclerosis	NOUN
dpc-3965	3	28	,	,	PUNCT
dpc-3965	3	29	hyaluronidase	hyaluronidase	INTJ
dpc-3965	3	30	,	,	PUNCT
dpc-3965	3	31	microstomia	microstomia	NOUN
dpc-3965	3	32	citation	citation	NOUN
dpc-3965	3	33	:	:	PUNCT
dpc-3965	3	34	pulumati	pulumati	PROPN
dpc-3965	3	35	a	a	PROPN
dpc-3965	3	36	,	,	PUNCT
dpc-3965	3	37	lin	lin	PROPN
dpc-3965	3	38	r	r	PROPN
dpc-3965	3	39	,	,	PUNCT
dpc-3965	3	40	elman	elman	PROPN
dpc-3965	3	41	sa	sa	PROPN
dpc-3965	3	42	.	.	PUNCT
dpc-3965	4	1	therapeutic	therapeutic	ADJ
dpc-3965	4	2	promise	promise	NOUN
dpc-3965	4	3	of	of	ADP
dpc-3965	4	4	hyaluronidase	hyaluronidase	NOUN
dpc-3965	4	5	in	in	ADP
dpc-3965	4	6	systemic	systemic	ADJ
dpc-3965	4	7	sclerosis	sclerosis	NOUN
dpc-3965	4	8	:	:	PUNCT
dpc-3965	4	9	a	a	DET
dpc-3965	4	10	systematic	systematic	ADJ
dpc-3965	4	11	review	review	NOUN
dpc-3965	4	12	.	.	PUNCT
dpc-3965	5	1	dermatol	dermatol	NOUN
dpc-3965	5	2	pract	pract	PROPN
dpc-3965	5	3	concept	concept	NOUN
dpc-3965	5	4	.	.	PUNCT
dpc-3965	6	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	6	2	.	.	X
dpc-3965	6	3	doi	doi	PROPN
dpc-3965	6	4	:	:	PUNCT
dpc-3965	6	5	https://doi.org/10.5826/dpc.1403a163	https://doi.org/10.5826/dpc.1403a163	PROPN
dpc-3965	6	6	accepted	accept	VERB
dpc-3965	6	7	:	:	PUNCT
dpc-3965	6	8	february	february	PROPN
dpc-3965	6	9	13	13	NUM
dpc-3965	6	10	,	,	PUNCT
dpc-3965	6	11	2024	2024	NUM
dpc-3965	6	12	;	;	PUNCT
dpc-3965	6	13	published	publish	VERB
dpc-3965	6	14	:	:	PUNCT
dpc-3965	7	1	july	july	PROPN
dpc-3965	7	2	2024	2024	NUM
dpc-3965	7	3	copyright	copyright	NOUN
dpc-3965	7	4	:	:	PUNCT
dpc-3965	7	5	©	©	PROPN
dpc-3965	7	6	2024	2024	NUM
dpc-3965	7	7	pulumati	pulumati	NOUN
dpc-3965	7	8	et	et	PROPN
dpc-3965	7	9	al	al	PROPN
dpc-3965	7	10	.	.	PUNCT
dpc-3965	8	1	this	this	PRON
dpc-3965	8	2	is	be	AUX
dpc-3965	8	3	an	an	DET
dpc-3965	8	4	open	open	ADJ
dpc-3965	8	5	-	-	PUNCT
dpc-3965	8	6	access	access	NOUN
dpc-3965	8	7	article	article	NOUN
dpc-3965	8	8	distributed	distribute	VERB
dpc-3965	8	9	under	under	ADP
dpc-3965	8	10	the	the	DET
dpc-3965	8	11	terms	term	NOUN
dpc-3965	8	12	of	of	ADP
dpc-3965	8	13	the	the	DET
dpc-3965	8	14	creative	creative	ADJ
dpc-3965	8	15	commons	common	NOUN
dpc-3965	8	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-3965	8	17	license	license	NOUN
dpc-3965	8	18	(	(	PUNCT
dpc-3965	8	19	by	by	ADP
dpc-3965	8	20	-	-	PUNCT
dpc-3965	8	21	nc-4.0	nc-4.0	NOUN
dpc-3965	8	22	)	)	PUNCT
dpc-3965	8	23	,	,	PUNCT
dpc-3965	8	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-3965	8	25	,	,	PUNCT
dpc-3965	8	26	which	which	PRON
dpc-3965	8	27	permits	permit	VERB
dpc-3965	8	28	unrestricted	unrestricted	ADJ
dpc-3965	8	29	noncommercial	noncommercial	ADJ
dpc-3965	8	30	use	use	NOUN
dpc-3965	8	31	,	,	PUNCT
dpc-3965	8	32	distribution	distribution	NOUN
dpc-3965	8	33	,	,	PUNCT
dpc-3965	8	34	and	and	CCONJ
dpc-3965	8	35	reproduction	reproduction	NOUN
dpc-3965	8	36	in	in	ADP
dpc-3965	8	37	any	any	DET
dpc-3965	8	38	medium	medium	NOUN
dpc-3965	8	39	,	,	PUNCT
dpc-3965	8	40	provided	provide	VERB
dpc-3965	8	41	the	the	DET
dpc-3965	8	42	original	original	ADJ
dpc-3965	8	43	authors	author	NOUN
dpc-3965	8	44	and	and	CCONJ
dpc-3965	8	45	source	source	NOUN
dpc-3965	8	46	are	be	AUX
dpc-3965	8	47	credited	credit	VERB
dpc-3965	8	48	.	.	PUNCT
dpc-3965	9	1	funding	funding	NOUN
dpc-3965	9	2	:	:	PUNCT
dpc-3965	9	3	none	none	NOUN
dpc-3965	9	4	.	.	PUNCT
dpc-3965	10	1	competing	compete	VERB
dpc-3965	10	2	interests	interest	NOUN
dpc-3965	10	3	:	:	PUNCT
dpc-3965	10	4	none	none	NOUN
dpc-3965	10	5	.	.	PUNCT
dpc-3965	11	1	authorship	authorship	NOUN
dpc-3965	11	2	:	:	PUNCT
dpc-3965	11	3	all	all	DET
dpc-3965	11	4	authors	author	NOUN
dpc-3965	11	5	have	have	AUX
dpc-3965	11	6	contributed	contribute	VERB
dpc-3965	11	7	significantly	significantly	ADV
dpc-3965	11	8	to	to	ADP
dpc-3965	11	9	this	this	DET
dpc-3965	11	10	publication	publication	NOUN
dpc-3965	11	11	.	.	PUNCT
dpc-3965	12	1	corresponding	correspond	VERB
dpc-3965	12	2	author	author	NOUN
dpc-3965	12	3	:	:	PUNCT
dpc-3965	12	4	anika	anika	PROPN
dpc-3965	12	5	pulumati	pulumati	PROPN
dpc-3965	12	6	,	,	PUNCT
dpc-3965	12	7	ba	ba	PROPN
dpc-3965	12	8	,	,	PUNCT
dpc-3965	12	9	university	university	PROPN
dpc-3965	12	10	of	of	ADP
dpc-3965	12	11	missouri	missouri	PROPN
dpc-3965	12	12	-	-	PROPN
dpc-3965	12	13	kansas	kansas	PROPN
dpc-3965	12	14	city	city	PROPN
dpc-3965	12	15	school	school	NOUN
dpc-3965	12	16	of	of	ADP
dpc-3965	12	17	medicine	medicine	NOUN
dpc-3965	12	18	,	,	PUNCT
dpc-3965	12	19	kansas	kansas	PROPN
dpc-3965	12	20	city	city	PROPN
dpc-3965	12	21	,	,	PUNCT
dpc-3965	12	22	mo	mo	PROPN
dpc-3965	12	23	,	,	PUNCT
dpc-3965	12	24	usa	usa	PROPN
dpc-3965	12	25	455	455	PROPN
dpc-3965	12	26	ne	ne	PROPN
dpc-3965	12	27	24th	24th	PROPN
dpc-3965	12	28	st	st	PROPN
dpc-3965	12	29	.	.	PROPN
dpc-3965	12	30	apt	apt	PROPN
dpc-3965	12	31	615	615	NUM
dpc-3965	12	32	miami	miami	PROPN
dpc-3965	12	33	,	,	PUNCT
dpc-3965	12	34	fl	fl	PROPN
dpc-3965	12	35	33137	33137	NUM
dpc-3965	12	36	.	.	PUNCT
dpc-3965	13	1	email	email	NOUN
dpc-3965	13	2	:	:	PUNCT
dpc-3965	13	3	alpc97@umsystem.edu	alpc97@umsystem.edu	VERB
dpc-3965	13	4	introduction	introduction	NOUN
dpc-3965	13	5	:	:	PUNCT
dpc-3965	13	6	systemic	systemic	ADJ
dpc-3965	13	7	sclerosis	sclerosis	NOUN
dpc-3965	13	8	,	,	PUNCT
dpc-3965	13	9	also	also	ADV
dpc-3965	13	10	known	know	VERB
dpc-3965	13	11	as	as	ADP
dpc-3965	13	12	scleroderma	scleroderma	NOUN
dpc-3965	13	13	,	,	PUNCT
dpc-3965	13	14	is	be	AUX
dpc-3965	13	15	a	a	DET
dpc-3965	13	16	chronic	chronic	ADJ
dpc-3965	13	17	disease	disease	NOUN
dpc-3965	13	18	marked	mark	VERB
dpc-3965	13	19	by	by	ADP
dpc-3965	13	20	autoimmune	autoimmune	ADJ
dpc-3965	13	21	-	-	PUNCT
dpc-3965	13	22	mediated	mediate	VERB
dpc-3965	13	23	damage	damage	NOUN
dpc-3965	13	24	to	to	ADP
dpc-3965	13	25	connective	connective	ADJ
dpc-3965	13	26	tissues	tissue	NOUN
dpc-3965	13	27	leading	lead	VERB
dpc-3965	13	28	to	to	ADP
dpc-3965	13	29	vascular	vascular	ADJ
dpc-3965	13	30	damage	damage	NOUN
dpc-3965	13	31	,	,	PUNCT
dpc-3965	13	32	tissue	tissue	NOUN
dpc-3965	13	33	injury	injury	NOUN
dpc-3965	13	34	,	,	PUNCT
dpc-3965	13	35	and	and	CCONJ
dpc-3965	13	36	fibrosis	fibrosis	NOUN
dpc-3965	13	37	.	.	PUNCT
dpc-3965	14	1	effective	effective	ADJ
dpc-3965	14	2	treatment	treatment	NOUN
dpc-3965	14	3	for	for	ADP
dpc-3965	14	4	this	this	DET
dpc-3965	14	5	condition	condition	NOUN
dpc-3965	14	6	has	have	AUX
dpc-3965	14	7	remained	remain	VERB
dpc-3965	14	8	difficult	difficult	ADJ
dpc-3965	14	9	;	;	PUNCT
dpc-3965	14	10	however	however	ADV
dpc-3965	14	11	,	,	PUNCT
dpc-3965	14	12	a	a	DET
dpc-3965	14	13	promising	promising	ADJ
dpc-3965	14	14	therapeutic	therapeutic	ADJ
dpc-3965	14	15	option	option	NOUN
dpc-3965	14	16	for	for	ADP
dpc-3965	14	17	patients	patient	NOUN
dpc-3965	14	18	with	with	ADP
dpc-3965	14	19	systemic	systemic	ADJ
dpc-3965	14	20	sclerosis	sclerosis	NOUN
dpc-3965	14	21	has	have	AUX
dpc-3965	14	22	emerged	emerge	VERB
dpc-3965	14	23	as	as	ADP
dpc-3965	14	24	hyaluronidase	hyaluronidase	ADV
dpc-3965	14	25	.	.	PUNCT
dpc-3965	15	1	objectives	objective	NOUN
dpc-3965	15	2	:	:	PUNCT
dpc-3965	15	3	we	we	PRON
dpc-3965	15	4	conducted	conduct	VERB
dpc-3965	15	5	a	a	DET
dpc-3965	15	6	systemic	systemic	ADJ
dpc-3965	15	7	review	review	NOUN
dpc-3965	15	8	of	of	ADP
dpc-3965	15	9	the	the	DET
dpc-3965	15	10	available	available	ADJ
dpc-3965	15	11	literature	literature	NOUN
dpc-3965	15	12	to	to	PART
dpc-3965	15	13	describe	describe	VERB
dpc-3965	15	14	the	the	DET
dpc-3965	15	15	therapeutic	therapeutic	ADJ
dpc-3965	15	16	usage	usage	NOUN
dpc-3965	15	17	of	of	ADP
dpc-3965	15	18	hyaluronidase	hyaluronidase	NOUN
dpc-3965	15	19	in	in	ADP
dpc-3965	15	20	systemic	systemic	ADJ
dpc-3965	15	21	sclerosis	sclerosis	NOUN
dpc-3965	15	22	.	.	PUNCT
dpc-3965	16	1	methods	method	NOUN
dpc-3965	16	2	:	:	PUNCT
dpc-3965	16	3	we	we	PRON
dpc-3965	16	4	conducted	conduct	VERB
dpc-3965	16	5	a	a	DET
dpc-3965	16	6	comprehensive	comprehensive	ADJ
dpc-3965	16	7	review	review	NOUN
dpc-3965	16	8	on	on	ADP
dpc-3965	16	9	pubmed	pubmed	PROPN
dpc-3965	16	10	and	and	CCONJ
dpc-3965	16	11	embase	embase	PROPN
dpc-3965	16	12	,	,	PUNCT
dpc-3965	16	13	using	use	VERB
dpc-3965	16	14	the	the	DET
dpc-3965	16	15	terms	term	NOUN
dpc-3965	16	16	:	:	PUNCT
dpc-3965	16	17	“	"	PUNCT
dpc-3965	16	18	hyaluronidase	hyaluronidase	ADJ
dpc-3965	16	19	”	"	PUNCT
dpc-3965	16	20	and	and	CCONJ
dpc-3965	16	21	“	"	PUNCT
dpc-3965	16	22	scleroderma	scleroderma	NOUN
dpc-3965	16	23	,	,	PUNCT
dpc-3965	16	24	”	"	PUNCT
dpc-3965	16	25	as	as	ADV
dpc-3965	16	26	well	well	ADV
dpc-3965	16	27	as	as	ADP
dpc-3965	16	28	“	"	PUNCT
dpc-3965	16	29	hyaluronidase	hyaluronidase	NOUN
dpc-3965	16	30	”	"	PUNCT
dpc-3965	16	31	and	and	CCONJ
dpc-3965	16	32	“	"	PUNCT
dpc-3965	16	33	systemic	systemic	ADJ
dpc-3965	16	34	sclerosis	sclerosis	NOUN
dpc-3965	16	35	.	.	PUNCT
dpc-3965	16	36	”	"	PUNCT
dpc-3965	17	1	our	our	PRON
dpc-3965	17	2	criteria	criterion	NOUN
dpc-3965	17	3	for	for	ADP
dpc-3965	17	4	inclusion	inclusion	NOUN
dpc-3965	17	5	were	be	AUX
dpc-3965	17	6	english	english	NOUN
dpc-3965	17	7	-	-	PUNCT
dpc-3965	17	8	written	write	VERB
dpc-3965	17	9	articles	article	NOUN
dpc-3965	17	10	published	publish	VERB
dpc-3965	17	11	between	between	ADP
dpc-3965	17	12	2013	2013	NUM
dpc-3965	17	13	and	and	CCONJ
dpc-3965	17	14	2023	2023	NUM
dpc-3965	17	15	.	.	PUNCT
dpc-3965	18	1	only	only	ADV
dpc-3965	18	2	studies	study	NOUN
dpc-3965	18	3	conducted	conduct	VERB
dpc-3965	18	4	on	on	ADP
dpc-3965	18	5	human	human	ADJ
dpc-3965	18	6	subjects	subject	NOUN
dpc-3965	18	7	or	or	CCONJ
dpc-3965	18	8	in	in	ADP
dpc-3965	18	9	vitro	vitro	X
dpc-3965	18	10	on	on	ADP
dpc-3965	18	11	human	human	ADJ
dpc-3965	18	12	cell	cell	NOUN
dpc-3965	18	13	lines	line	NOUN
dpc-3965	18	14	were	be	AUX
dpc-3965	18	15	included	include	VERB
dpc-3965	18	16	.	.	PUNCT
dpc-3965	19	1	we	we	PRON
dpc-3965	19	2	excluded	exclude	VERB
dpc-3965	19	3	articles	article	NOUN
dpc-3965	19	4	that	that	PRON
dpc-3965	19	5	did	do	AUX
dpc-3965	19	6	not	not	PART
dpc-3965	19	7	discuss	discuss	VERB
dpc-3965	19	8	therapeutic	therapeutic	ADJ
dpc-3965	19	9	use	use	NOUN
dpc-3965	19	10	as	as	ADV
dpc-3965	19	11	well	well	ADV
dpc-3965	19	12	as	as	ADP
dpc-3965	19	13	articles	article	NOUN
dpc-3965	19	14	that	that	PRON
dpc-3965	19	15	focused	focus	VERB
dpc-3965	19	16	on	on	ADP
dpc-3965	19	17	medical	medical	ADJ
dpc-3965	19	18	conditions	condition	NOUN
dpc-3965	19	19	other	other	ADJ
dpc-3965	19	20	than	than	ADP
dpc-3965	19	21	systemic	systemic	ADJ
dpc-3965	19	22	sclerosis	sclerosis	NOUN
dpc-3965	19	23	.	.	PUNCT
dpc-3965	20	1	results	result	NOUN
dpc-3965	20	2	:	:	PUNCT
dpc-3965	20	3	ten	ten	NUM
dpc-3965	20	4	articles	article	NOUN
dpc-3965	20	5	were	be	AUX
dpc-3965	20	6	included	include	VERB
dpc-3965	20	7	in	in	ADP
dpc-3965	20	8	our	our	PRON
dpc-3965	20	9	review	review	NOUN
dpc-3965	20	10	.	.	PUNCT
dpc-3965	21	1	overall	overall	ADV
dpc-3965	21	2	,	,	PUNCT
dpc-3965	21	3	intradermal	intradermal	ADJ
dpc-3965	21	4	hyaluronidase	hyaluronidase	NOUN
dpc-3965	21	5	showed	show	VERB
dpc-3965	21	6	improvement	improvement	NOUN
dpc-3965	21	7	in	in	ADP
dpc-3965	21	8	systemic	systemic	ADJ
dpc-3965	21	9	sclerosis	sclerosis	NOUN
dpc-3965	21	10	-	-	PUNCT
dpc-3965	21	11	associated	associate	VERB
dpc-3965	21	12	microstomia	microstomia	NOUN
dpc-3965	21	13	via	via	ADP
dpc-3965	21	14	increased	increase	VERB
dpc-3965	21	15	oral	oral	ADJ
dpc-3965	21	16	aperture	aperture	NOUN
dpc-3965	21	17	with	with	ADP
dpc-3965	21	18	minimal	minimal	ADJ
dpc-3965	21	19	side	side	NOUN
dpc-3965	21	20	effects	effect	NOUN
dpc-3965	21	21	.	.	PUNCT
dpc-3965	22	1	treatment	treatment	NOUN
dpc-3965	22	2	protocol	protocol	NOUN
dpc-3965	22	3	and	and	CCONJ
dpc-3965	22	4	outcome	outcome	NOUN
dpc-3965	22	5	measured	measure	VERB
dpc-3965	22	6	differed	differ	VERB
dpc-3965	22	7	per	per	ADP
dpc-3965	22	8	case	case	NOUN
dpc-3965	22	9	,	,	PUNCT
dpc-3965	22	10	however	however	ADV
dpc-3965	22	11	,	,	PUNCT
dpc-3965	22	12	multiple	multiple	ADJ
dpc-3965	22	13	rounds	round	NOUN
dpc-3965	22	14	of	of	ADP
dpc-3965	22	15	injections	injection	NOUN
dpc-3965	22	16	were	be	AUX
dpc-3965	22	17	necessary	necessary	ADJ
dpc-3965	22	18	in	in	ADP
dpc-3965	22	19	all	all	DET
dpc-3965	22	20	treatment	treatment	NOUN
dpc-3965	22	21	courses	course	NOUN
dpc-3965	22	22	.	.	PUNCT
dpc-3965	23	1	in	in	ADP
dpc-3965	23	2	some	some	DET
dpc-3965	23	3	studies	study	NOUN
dpc-3965	23	4	,	,	PUNCT
dpc-3965	23	5	a	a	DET
dpc-3965	23	6	plateauing	plateauing	NOUN
dpc-3965	23	7	effect	effect	NOUN
dpc-3965	23	8	for	for	ADP
dpc-3965	23	9	hyaluronidase	hyaluronidase	NOUN
dpc-3965	23	10	was	be	AUX
dpc-3965	23	11	seen	see	VERB
dpc-3965	23	12	after	after	ADP
dpc-3965	23	13	3	3	NUM
dpc-3965	23	14	-	-	SYM
dpc-3965	23	15	5	5	NUM
dpc-3965	23	16	months	month	NOUN
dpc-3965	23	17	of	of	ADP
dpc-3965	23	18	injections	injection	NOUN
dpc-3965	23	19	.	.	PUNCT
dpc-3965	24	1	conclusions	conclusion	NOUN
dpc-3965	24	2	:	:	PUNCT
dpc-3965	24	3	case	case	NOUN
dpc-3965	24	4	studies	study	NOUN
dpc-3965	24	5	and	and	CCONJ
dpc-3965	24	6	case	case	NOUN
dpc-3965	24	7	series	series	NOUN
dpc-3965	24	8	have	have	AUX
dpc-3965	24	9	demonstrated	demonstrate	VERB
dpc-3965	24	10	hyaluronidase	hyaluronidase	ADJ
dpc-3965	24	11	effectiveness	effectiveness	NOUN
dpc-3965	24	12	in	in	ADP
dpc-3965	24	13	treating	treat	VERB
dpc-3965	24	14	systemic	systemic	ADJ
dpc-3965	24	15	sclerosis	sclerosis	NOUN
dpc-3965	24	16	-	-	PUNCT
dpc-3965	24	17	associated	associate	VERB
dpc-3965	24	18	microstomia	microstomia	NOUN
dpc-3965	24	19	,	,	PUNCT
dpc-3965	24	20	however	however	ADV
dpc-3965	24	21	,	,	PUNCT
dpc-3965	24	22	more	more	ADJ
dpc-3965	24	23	research	research	NOUN
dpc-3965	24	24	using	use	VERB
dpc-3965	24	25	larger	large	ADJ
dpc-3965	24	26	sample	sample	NOUN
dpc-3965	24	27	sizes	size	NOUN
dpc-3965	24	28	,	,	PUNCT
dpc-3965	24	29	standardized	standardized	ADJ
dpc-3965	24	30	protocols	protocol	NOUN
dpc-3965	24	31	,	,	PUNCT
dpc-3965	24	32	and	and	CCONJ
dpc-3965	24	33	specific	specific	ADJ
dpc-3965	24	34	outcomes	outcome	NOUN
dpc-3965	24	35	such	such	ADJ
dpc-3965	24	36	be	be	AUX
dpc-3965	24	37	conducted	conduct	VERB
dpc-3965	24	38	.	.	PUNCT
dpc-3965	25	1	abstract	abstract	ADJ
dpc-3965	25	2	2	2	NUM
dpc-3965	25	3	review	review	NOUN
dpc-3965	25	4	|	|	ADV
dpc-3965	25	5	dermatol	dermatol	ADJ
dpc-3965	25	6	pract	pract	NOUN
dpc-3965	25	7	concept	concept	NOUN
dpc-3965	25	8	.	.	PUNCT
dpc-3965	26	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	26	2	introduction	introduction	NOUN
dpc-3965	26	3	systemic	systemic	ADJ
dpc-3965	26	4	sclerosis	sclerosis	NOUN
dpc-3965	26	5	(	(	PUNCT
dpc-3965	26	6	ssc	ssc	NOUN
dpc-3965	26	7	)	)	PUNCT
dpc-3965	26	8	,	,	PUNCT
dpc-3965	26	9	also	also	ADV
dpc-3965	26	10	known	know	VERB
dpc-3965	26	11	as	as	ADP
dpc-3965	26	12	scleroderma	scleroderma	NOUN
dpc-3965	26	13	,	,	PUNCT
dpc-3965	26	14	is	be	AUX
dpc-3965	26	15	a	a	DET
dpc-3965	26	16	rare	rare	ADJ
dpc-3965	26	17	autoimmune	autoimmune	ADJ
dpc-3965	26	18	connective	connective	ADJ
dpc-3965	26	19	tissue	tissue	NOUN
dpc-3965	26	20	disorder	disorder	NOUN
dpc-3965	26	21	with	with	ADP
dpc-3965	26	22	a	a	DET
dpc-3965	26	23	very	very	ADV
dpc-3965	26	24	complex	complex	ADJ
dpc-3965	26	25	and	and	CCONJ
dpc-3965	26	26	poorly	poorly	ADV
dpc-3965	26	27	understood	understand	VERB
dpc-3965	26	28	pathogenesis	pathogenesis	NOUN
dpc-3965	26	29	,	,	PUNCT
dpc-3965	26	30	presenting	present	VERB
dpc-3965	26	31	a	a	DET
dpc-3965	26	32	challenge	challenge	NOUN
dpc-3965	26	33	to	to	ADP
dpc-3965	26	34	both	both	DET
dpc-3965	26	35	patients	patient	NOUN
dpc-3965	26	36	and	and	CCONJ
dpc-3965	26	37	physicians	physician	NOUN
dpc-3965	26	38	.	.	PUNCT
dpc-3965	27	1	scleroderma	scleroderma	PROPN
dpc-3965	27	2	can	can	AUX
dpc-3965	27	3	manifest	manifest	VERB
dpc-3965	27	4	in	in	ADP
dpc-3965	27	5	two	two	NUM
dpc-3965	27	6	principal	principal	ADJ
dpc-3965	27	7	forms	form	NOUN
dpc-3965	27	8	:	:	PUNCT
dpc-3965	27	9	limited	limited	ADJ
dpc-3965	27	10	ssc	ssc	PROPN
dpc-3965	27	11	,	,	PUNCT
dpc-3965	27	12	formerly	formerly	ADV
dpc-3965	27	13	known	know	VERB
dpc-3965	27	14	as	as	ADP
dpc-3965	27	15	crest	crest	NOUN
dpc-3965	27	16	syndrome	syndrome	NOUN
dpc-3965	27	17	,	,	PUNCT
dpc-3965	27	18	or	or	CCONJ
dpc-3965	27	19	diffuse	diffuse	VERB
dpc-3965	27	20	ssc	ssc	NOUN
dpc-3965	27	21	depending	depend	VERB
dpc-3965	27	22	on	on	ADP
dpc-3965	27	23	the	the	DET
dpc-3965	27	24	combination	combination	NOUN
dpc-3965	27	25	of	of	ADP
dpc-3965	27	26	both	both	CCONJ
dpc-3965	27	27	clinical	clinical	ADJ
dpc-3965	27	28	and	and	CCONJ
dpc-3965	27	29	serological	serological	ADJ
dpc-3965	27	30	criteria	criterion	NOUN
dpc-3965	27	31	[	[	X
dpc-3965	27	32	1	1	NUM
dpc-3965	27	33	]	]	PUNCT
dpc-3965	27	34	.	.	PUNCT
dpc-3965	28	1	among	among	ADP
dpc-3965	28	2	the	the	DET
dpc-3965	28	3	numerous	numerous	ADJ
dpc-3965	28	4	complications	complication	NOUN
dpc-3965	28	5	associated	associate	VERB
dpc-3965	28	6	with	with	ADP
dpc-3965	28	7	ssc	ssc	PROPN
dpc-3965	28	8	,	,	PUNCT
dpc-3965	28	9	the	the	DET
dpc-3965	28	10	development	development	NOUN
dpc-3965	28	11	of	of	ADP
dpc-3965	28	12	microstomia	microstomia	NOUN
dpc-3965	28	13	,	,	PUNCT
dpc-3965	28	14	characterized	characterize	VERB
dpc-3965	28	15	by	by	ADP
dpc-3965	28	16	progressive	progressive	ADJ
dpc-3965	28	17	narrowing	narrowing	NOUN
dpc-3965	28	18	of	of	ADP
dpc-3965	28	19	the	the	DET
dpc-3965	28	20	oral	oral	ADJ
dpc-3965	28	21	orifice	orifice	NOUN
dpc-3965	28	22	due	due	ADP
dpc-3965	28	23	to	to	ADP
dpc-3965	28	24	perioral	perioral	ADJ
dpc-3965	28	25	soft	soft	ADJ
dpc-3965	28	26	tissue	tissue	NOUN
dpc-3965	28	27	fibrosis	fibrosis	NOUN
dpc-3965	28	28	,	,	PUNCT
dpc-3965	28	29	is	be	AUX
dpc-3965	28	30	recognized	recognize	VERB
dpc-3965	28	31	as	as	ADP
dpc-3965	28	32	a	a	DET
dpc-3965	28	33	particularly	particularly	ADV
dpc-3965	28	34	distressing	distressing	ADJ
dpc-3965	28	35	one	one	NUM
dpc-3965	28	36	[	[	X
dpc-3965	28	37	2	2	NUM
dpc-3965	28	38	]	]	PUNCT
dpc-3965	28	39	.	.	PUNCT
dpc-3965	29	1	true	true	ADJ
dpc-3965	29	2	microstomia	microstomia	NOUN
dpc-3965	29	3	affects	affect	VERB
dpc-3965	29	4	approximately	approximately	ADV
dpc-3965	29	5	30	30	NUM
dpc-3965	29	6	%	%	NOUN
dpc-3965	29	7	of	of	ADP
dpc-3965	29	8	these	these	DET
dpc-3965	29	9	patients	patient	NOUN
dpc-3965	29	10	and	and	CCONJ
dpc-3965	29	11	may	may	AUX
dpc-3965	29	12	have	have	VERB
dpc-3965	29	13	a	a	DET
dpc-3965	29	14	profound	profound	ADJ
dpc-3965	29	15	negative	negative	ADJ
dpc-3965	29	16	impact	impact	NOUN
dpc-3965	29	17	on	on	ADP
dpc-3965	29	18	a	a	DET
dpc-3965	29	19	patient	patient	ADJ
dpc-3965	29	20	overall	overall	ADJ
dpc-3965	29	21	quality	quality	NOUN
dpc-3965	29	22	of	of	ADP
dpc-3965	29	23	life	life	NOUN
dpc-3965	29	24	,	,	PUNCT
dpc-3965	29	25	for	for	ADP
dpc-3965	29	26	example	example	NOUN
dpc-3965	29	27	,	,	PUNCT
dpc-3965	29	28	restricted	restrict	VERB
dpc-3965	29	29	mouth	mouth	NOUN
dpc-3965	29	30	opening	opening	NOUN
dpc-3965	29	31	may	may	AUX
dpc-3965	29	32	impair	impair	VERB
dpc-3965	29	33	eating	eating	NOUN
dpc-3965	29	34	,	,	PUNCT
dpc-3965	29	35	speech	speech	NOUN
dpc-3965	29	36	,	,	PUNCT
dpc-3965	29	37	or	or	CCONJ
dpc-3965	29	38	oral	oral	ADJ
dpc-3965	29	39	hygiene	hygiene	NOUN
dpc-3965	30	1	[	[	X
dpc-3965	30	2	3	3	NUM
dpc-3965	30	3	-	-	SYM
dpc-3965	30	4	5	5	NUM
dpc-3965	30	5	]	]	PUNCT
dpc-3965	30	6	.	.	PUNCT
dpc-3965	31	1	in	in	ADP
dpc-3965	31	2	search	search	NOUN
dpc-3965	31	3	of	of	ADP
dpc-3965	31	4	therapeutic	therapeutic	ADJ
dpc-3965	31	5	interventions	intervention	NOUN
dpc-3965	31	6	to	to	PART
dpc-3965	31	7	address	address	VERB
dpc-3965	31	8	this	this	DET
dpc-3965	31	9	complication	complication	NOUN
dpc-3965	31	10	,	,	PUNCT
dpc-3965	31	11	one	one	NUM
dpc-3965	31	12	avenue	avenue	NOUN
dpc-3965	31	13	currently	currently	ADV
dpc-3965	31	14	being	be	AUX
dpc-3965	31	15	investigated	investigate	VERB
dpc-3965	31	16	holds	hold	VERB
dpc-3965	31	17	potential	potential	NOUN
dpc-3965	31	18	:	:	PUNCT
dpc-3965	31	19	hyaluronidase	hyaluronidase	NOUN
dpc-3965	31	20	injections	injection	NOUN
dpc-3965	31	21	.	.	PUNCT
dpc-3965	32	1	hyaluronidase	hyaluronidase	NOUN
dpc-3965	32	2	plays	play	VERB
dpc-3965	32	3	a	a	DET
dpc-3965	32	4	crucial	crucial	ADJ
dpc-3965	32	5	role	role	NOUN
dpc-3965	32	6	in	in	ADP
dpc-3965	32	7	degrading	degrade	VERB
dpc-3965	32	8	hyaluronic	hyaluronic	ADJ
dpc-3965	32	9	acid	acid	NOUN
dpc-3965	32	10	(	(	PUNCT
dpc-3965	32	11	ha	ha	INTJ
dpc-3965	32	12	)	)	PUNCT
dpc-3965	32	13	within	within	ADP
dpc-3965	32	14	the	the	DET
dpc-3965	32	15	extracellular	extracellular	ADJ
dpc-3965	32	16	matrix	matrix	NOUN
dpc-3965	32	17	(	(	PUNCT
dpc-3965	32	18	ecm	ecm	PROPN
dpc-3965	32	19	)	)	PUNCT
dpc-3965	32	20	,	,	PUNCT
dpc-3965	32	21	thus	thus	ADV
dpc-3965	32	22	offering	offer	VERB
dpc-3965	32	23	a	a	DET
dpc-3965	32	24	potential	potential	ADJ
dpc-3965	32	25	therapeutic	therapeutic	ADJ
dpc-3965	32	26	option	option	NOUN
dpc-3965	32	27	for	for	ADP
dpc-3965	32	28	alleviating	alleviate	VERB
dpc-3965	32	29	the	the	DET
dpc-3965	32	30	fibrosis	fibrosis	NOUN
dpc-3965	32	31	and	and	CCONJ
dpc-3965	32	32	stiffness	stiffness	NOUN
dpc-3965	32	33	associated	associate	VERB
dpc-3965	32	34	with	with	ADP
dpc-3965	32	35	microstomia	microstomia	NOUN
dpc-3965	32	36	in	in	ADP
dpc-3965	32	37	these	these	DET
dpc-3965	32	38	patients	patient	NOUN
dpc-3965	32	39	[	[	X
dpc-3965	32	40	6	6	NUM
dpc-3965	32	41	]	]	PUNCT
dpc-3965	32	42	.	.	PUNCT
dpc-3965	33	1	objectives	objective	VERB
dpc-3965	33	2	the	the	DET
dpc-3965	33	3	purpose	purpose	NOUN
dpc-3965	33	4	of	of	ADP
dpc-3965	33	5	this	this	DET
dpc-3965	33	6	paper	paper	NOUN
dpc-3965	33	7	is	be	AUX
dpc-3965	33	8	to	to	PART
dpc-3965	33	9	thoroughly	thoroughly	ADV
dpc-3965	33	10	explore	explore	VERB
dpc-3965	33	11	and	and	CCONJ
dpc-3965	33	12	evaluate	evaluate	VERB
dpc-3965	33	13	the	the	DET
dpc-3965	33	14	potential	potential	NOUN
dpc-3965	33	15	of	of	ADP
dpc-3965	33	16	hyaluronidase	hyaluronidase	NOUN
dpc-3965	33	17	in	in	ADP
dpc-3965	33	18	the	the	DET
dpc-3965	33	19	context	context	NOUN
dpc-3965	33	20	of	of	ADP
dpc-3965	33	21	ssc	ssc	NOUN
dpc-3965	33	22	,	,	PUNCT
dpc-3965	33	23	particularly	particularly	ADV
dpc-3965	33	24	in	in	ADP
dpc-3965	33	25	the	the	DET
dpc-3965	33	26	management	management	NOUN
dpc-3965	33	27	of	of	ADP
dpc-3965	33	28	microstomia	microstomia	NOUN
dpc-3965	33	29	.	.	PUNCT
dpc-3965	34	1	we	we	PRON
dpc-3965	34	2	aim	aim	VERB
dpc-3965	34	3	to	to	PART
dpc-3965	34	4	systematically	systematically	ADV
dpc-3965	34	5	synthesize	synthesize	VERB
dpc-3965	34	6	and	and	CCONJ
dpc-3965	34	7	analyze	analyze	VERB
dpc-3965	34	8	the	the	DET
dpc-3965	34	9	current	current	ADJ
dpc-3965	34	10	literature	literature	NOUN
dpc-3965	34	11	to	to	PART
dpc-3965	34	12	better	well	ADV
dpc-3965	34	13	understand	understand	VERB
dpc-3965	34	14	the	the	DET
dpc-3965	34	15	extent	extent	NOUN
dpc-3965	34	16	of	of	ADP
dpc-3965	34	17	hyaluronidase	hyaluronidase	NOUN
dpc-3965	34	18	effectiveness	effectiveness	NOUN
dpc-3965	34	19	,	,	PUNCT
dpc-3965	34	20	as	as	ADV
dpc-3965	34	21	well	well	ADV
dpc-3965	34	22	as	as	ADP
dpc-3965	34	23	the	the	DET
dpc-3965	34	24	potential	potential	ADJ
dpc-3965	34	25	advantages	advantage	NOUN
dpc-3965	34	26	and	and	CCONJ
dpc-3965	34	27	limitations	limitation	NOUN
dpc-3965	34	28	it	it	PRON
dpc-3965	34	29	holds	hold	VERB
dpc-3965	34	30	.	.	PUNCT
dpc-3965	35	1	we	we	PRON
dpc-3965	35	2	hope	hope	VERB
dpc-3965	35	3	to	to	PART
dpc-3965	35	4	facilitate	facilitate	VERB
dpc-3965	35	5	more	more	ADV
dpc-3965	35	6	informed	informed	ADJ
dpc-3965	35	7	decision	decision	NOUN
dpc-3965	35	8	-	-	PUNCT
dpc-3965	35	9	making	making	NOUN
dpc-3965	35	10	by	by	ADP
dpc-3965	35	11	physicians	physician	NOUN
dpc-3965	35	12	when	when	SCONJ
dpc-3965	35	13	considering	consider	VERB
dpc-3965	35	14	the	the	DET
dpc-3965	35	15	use	use	NOUN
dpc-3965	35	16	of	of	ADP
dpc-3965	35	17	hyaluronidase	hyaluronidase	NOUN
dpc-3965	35	18	to	to	PART
dpc-3965	35	19	manage	manage	VERB
dpc-3965	35	20	this	this	DET
dpc-3965	35	21	complication	complication	NOUN
dpc-3965	35	22	in	in	ADP
dpc-3965	35	23	ssc	ssc	NOUN
dpc-3965	35	24	patients	patient	NOUN
dpc-3965	35	25	.	.	PUNCT
dpc-3965	36	1	ultimately	ultimately	ADV
dpc-3965	36	2	,	,	PUNCT
dpc-3965	36	3	our	our	PRON
dpc-3965	36	4	goal	goal	NOUN
dpc-3965	36	5	is	be	AUX
dpc-3965	36	6	to	to	PART
dpc-3965	36	7	advance	advance	VERB
dpc-3965	36	8	evidence	evidence	NOUN
dpc-3965	36	9	-	-	PUNCT
dpc-3965	36	10	based	base	VERB
dpc-3965	36	11	therapies	therapy	NOUN
dpc-3965	36	12	and	and	CCONJ
dpc-3965	36	13	enhance	enhance	VERB
dpc-3965	36	14	the	the	DET
dpc-3965	36	15	overall	overall	ADJ
dpc-3965	36	16	quality	quality	NOUN
dpc-3965	36	17	of	of	ADP
dpc-3965	36	18	life	life	NOUN
dpc-3965	36	19	of	of	ADP
dpc-3965	36	20	ssc	ssc	NOUN
dpc-3965	36	21	patients	patient	NOUN
dpc-3965	36	22	by	by	ADP
dpc-3965	36	23	offering	offer	VERB
dpc-3965	36	24	practical	practical	ADJ
dpc-3965	36	25	insights	insight	NOUN
dpc-3965	36	26	and	and	CCONJ
dpc-3965	36	27	evidence	evidence	NOUN
dpc-3965	36	28	-	-	PUNCT
dpc-3965	36	29	based	base	VERB
dpc-3965	36	30	recommendations	recommendation	NOUN
dpc-3965	36	31	in	in	ADP
dpc-3965	36	32	addressing	address	VERB
dpc-3965	36	33	the	the	DET
dpc-3965	36	34	multifaceted	multifaceted	ADJ
dpc-3965	36	35	challenges	challenge	NOUN
dpc-3965	36	36	presented	present	VERB
dpc-3965	36	37	by	by	ADP
dpc-3965	36	38	ssc	ssc	PROPN
dpc-3965	36	39	.	.	PUNCT
dpc-3965	37	1	methods	method	NOUN
dpc-3965	37	2	this	this	DET
dpc-3965	37	3	systematic	systematic	ADJ
dpc-3965	37	4	review	review	NOUN
dpc-3965	37	5	was	be	AUX
dpc-3965	37	6	conducted	conduct	VERB
dpc-3965	37	7	in	in	ADP
dpc-3965	37	8	adherence	adherence	NOUN
dpc-3965	37	9	to	to	ADP
dpc-3965	37	10	the	the	DET
dpc-3965	37	11	standards	standard	NOUN
dpc-3965	37	12	outlined	outline	VERB
dpc-3965	37	13	in	in	ADP
dpc-3965	37	14	the	the	DET
dpc-3965	37	15	preferred	preferred	ADJ
dpc-3965	37	16	reporting	reporting	NOUN
dpc-3965	37	17	items	item	NOUN
dpc-3965	37	18	for	for	ADP
dpc-3965	37	19	systematic	systematic	ADJ
dpc-3965	37	20	review	review	NOUN
dpc-3965	37	21	and	and	CCONJ
dpc-3965	37	22	meta	meta	ADJ
dpc-3965	37	23	-	-	PUNCT
dpc-3965	37	24	analysis	analysis	NOUN
dpc-3965	37	25	(	(	PUNCT
dpc-3965	37	26	prisma	prisma	NOUN
dpc-3965	37	27	)	)	PUNCT
dpc-3965	37	28	statement	statement	NOUN
dpc-3965	37	29	.	.	PUNCT
dpc-3965	38	1	this	this	DET
dpc-3965	38	2	section	section	NOUN
dpc-3965	38	3	outlines	outline	VERB
dpc-3965	38	4	our	our	PRON
dpc-3965	38	5	search	search	NOUN
dpc-3965	38	6	strategy	strategy	NOUN
dpc-3965	38	7	as	as	ADV
dpc-3965	38	8	well	well	ADV
dpc-3965	38	9	as	as	ADP
dpc-3965	38	10	our	our	PRON
dpc-3965	38	11	inclusion	inclusion	NOUN
dpc-3965	38	12	and	and	CCONJ
dpc-3965	38	13	exclusion	exclusion	NOUN
dpc-3965	38	14	criteria	criterion	NOUN
dpc-3965	38	15	that	that	PRON
dpc-3965	38	16	were	be	AUX
dpc-3965	38	17	used	use	VERB
dpc-3965	38	18	to	to	PART
dpc-3965	38	19	identify	identify	VERB
dpc-3965	38	20	and	and	CCONJ
dpc-3965	38	21	select	select	VERB
dpc-3965	38	22	pertinent	pertinent	ADJ
dpc-3965	38	23	articles	article	NOUN
dpc-3965	38	24	for	for	ADP
dpc-3965	38	25	our	our	PRON
dpc-3965	38	26	investigation	investigation	NOUN
dpc-3965	38	27	,	,	PUNCT
dpc-3965	38	28	all	all	PRON
dpc-3965	38	29	in	in	ADP
dpc-3965	38	30	accordance	accordance	NOUN
dpc-3965	38	31	with	with	ADP
dpc-3965	38	32	the	the	DET
dpc-3965	38	33	prisma	prisma	PROPN
dpc-3965	38	34	guidelines	guideline	NOUN
dpc-3965	38	35	.	.	PUNCT
dpc-3965	39	1	we	we	PRON
dpc-3965	39	2	conducted	conduct	VERB
dpc-3965	39	3	a	a	DET
dpc-3965	39	4	comprehensive	comprehensive	ADJ
dpc-3965	39	5	search	search	NOUN
dpc-3965	39	6	,	,	PUNCT
dpc-3965	39	7	initially	initially	ADV
dpc-3965	39	8	on	on	ADP
dpc-3965	39	9	pubmed	pubmed	PROPN
dpc-3965	39	10	,	,	PUNCT
dpc-3965	39	11	using	use	VERB
dpc-3965	39	12	the	the	DET
dpc-3965	39	13	following	follow	VERB
dpc-3965	39	14	search	search	NOUN
dpc-3965	39	15	terms	term	NOUN
dpc-3965	39	16	:	:	PUNCT
dpc-3965	39	17	“	"	PUNCT
dpc-3965	39	18	hyaluronidase	hyaluronidase	ADJ
dpc-3965	39	19	”	"	PUNCT
dpc-3965	39	20	and	and	CCONJ
dpc-3965	39	21	“	"	PUNCT
dpc-3965	39	22	scleroderma	scleroderma	NOUN
dpc-3965	39	23	,	,	PUNCT
dpc-3965	39	24	”	"	PUNCT
dpc-3965	39	25	as	as	ADV
dpc-3965	39	26	well	well	ADV
dpc-3965	39	27	as	as	ADP
dpc-3965	39	28	“	"	PUNCT
dpc-3965	39	29	hyaluronidase	hyaluronidase	NOUN
dpc-3965	39	30	”	"	PUNCT
dpc-3965	39	31	and	and	CCONJ
dpc-3965	39	32	“	"	PUNCT
dpc-3965	39	33	systemic	systemic	ADJ
dpc-3965	39	34	sclerosis	sclerosis	NOUN
dpc-3965	39	35	”	"	PUNCT
dpc-3965	39	36	which	which	PRON
dpc-3965	39	37	yielded	yield	VERB
dpc-3965	39	38	43	43	NUM
dpc-3965	39	39	relevant	relevant	ADJ
dpc-3965	39	40	articles	article	NOUN
dpc-3965	39	41	.	.	PUNCT
dpc-3965	40	1	after	after	SCONJ
dpc-3965	40	2	duplicate	duplicate	ADJ
dpc-3965	40	3	articles	article	NOUN
dpc-3965	40	4	were	be	AUX
dpc-3965	40	5	removed	remove	VERB
dpc-3965	40	6	,	,	PUNCT
dpc-3965	40	7	we	we	PRON
dpc-3965	40	8	assessed	assess	VERB
dpc-3965	40	9	the	the	DET
dpc-3965	40	10	title	title	NOUN
dpc-3965	40	11	,	,	PUNCT
dpc-3965	40	12	abstract	abstract	ADJ
dpc-3965	40	13	,	,	PUNCT
dpc-3965	40	14	and	and	CCONJ
dpc-3965	40	15	full	full	ADJ
dpc-3965	40	16	-	-	PUNCT
dpc-3965	40	17	text	text	NOUN
dpc-3965	40	18	of	of	ADP
dpc-3965	40	19	each	each	DET
dpc-3965	40	20	article	article	NOUN
dpc-3965	40	21	.	.	PUNCT
dpc-3965	41	1	seven	seven	NUM
dpc-3965	41	2	articles	article	NOUN
dpc-3965	41	3	following	follow	VERB
dpc-3965	41	4	the	the	DET
dpc-3965	41	5	predetermined	predetermine	VERB
dpc-3965	41	6	criteria	criterion	NOUN
dpc-3965	41	7	remained	remain	VERB
dpc-3965	41	8	which	which	PRON
dpc-3965	41	9	prompted	prompt	VERB
dpc-3965	41	10	us	we	PRON
dpc-3965	41	11	to	to	PART
dpc-3965	41	12	proceed	proceed	VERB
dpc-3965	41	13	with	with	ADP
dpc-3965	41	14	an	an	DET
dpc-3965	41	15	additional	additional	ADJ
dpc-3965	41	16	search	search	NOUN
dpc-3965	41	17	on	on	ADP
dpc-3965	41	18	a	a	DET
dpc-3965	41	19	different	different	ADJ
dpc-3965	41	20	database	database	NOUN
dpc-3965	41	21	.	.	PUNCT
dpc-3965	42	1	this	this	DET
dpc-3965	42	2	supplementary	supplementary	ADJ
dpc-3965	42	3	search	search	NOUN
dpc-3965	42	4	was	be	AUX
dpc-3965	42	5	conducted	conduct	VERB
dpc-3965	42	6	on	on	ADP
dpc-3965	42	7	embase	embase	NOUN
dpc-3965	42	8	using	use	VERB
dpc-3965	42	9	the	the	DET
dpc-3965	42	10	same	same	ADJ
dpc-3965	42	11	search	search	NOUN
dpc-3965	42	12	terms	term	NOUN
dpc-3965	42	13	yielding	yield	VERB
dpc-3965	42	14	96	96	NUM
dpc-3965	42	15	articles	article	NOUN
dpc-3965	42	16	and	and	CCONJ
dpc-3965	42	17	53	53	NUM
dpc-3965	42	18	articles	article	NOUN
dpc-3965	42	19	,	,	PUNCT
dpc-3965	42	20	respectively	respectively	ADV
dpc-3965	42	21	.	.	PUNCT
dpc-3965	43	1	after	after	ADP
dpc-3965	43	2	applying	apply	VERB
dpc-3965	43	3	the	the	DET
dpc-3965	43	4	predetermined	predetermine	VERB
dpc-3965	43	5	criteria	criterion	NOUN
dpc-3965	43	6	,	,	PUNCT
dpc-3965	43	7	three	three	NUM
dpc-3965	43	8	articles	article	NOUN
dpc-3965	43	9	remained	remain	VERB
dpc-3965	43	10	.	.	PUNCT
dpc-3965	44	1	after	after	ADP
dpc-3965	44	2	ensuring	ensure	VERB
dpc-3965	44	3	the	the	DET
dpc-3965	44	4	articles	article	NOUN
dpc-3965	44	5	met	meet	VERB
dpc-3965	44	6	our	our	PRON
dpc-3965	44	7	criteria	criterion	NOUN
dpc-3965	44	8	,	,	PUNCT
dpc-3965	44	9	a	a	DET
dpc-3965	44	10	total	total	NOUN
dpc-3965	44	11	of	of	ADP
dpc-3965	44	12	10	10	NUM
dpc-3965	44	13	articles	article	NOUN
dpc-3965	44	14	were	be	AUX
dpc-3965	44	15	used	use	VERB
dpc-3965	44	16	in	in	ADP
dpc-3965	44	17	this	this	DET
dpc-3965	44	18	review	review	NOUN
dpc-3965	44	19	.	.	PUNCT
dpc-3965	45	1	to	to	PART
dpc-3965	45	2	ensure	ensure	VERB
dpc-3965	45	3	the	the	DET
dpc-3965	45	4	relevance	relevance	NOUN
dpc-3965	45	5	and	and	CCONJ
dpc-3965	45	6	quality	quality	NOUN
dpc-3965	45	7	of	of	ADP
dpc-3965	45	8	the	the	DET
dpc-3965	45	9	selected	select	VERB
dpc-3965	45	10	articles	article	NOUN
dpc-3965	45	11	,	,	PUNCT
dpc-3965	45	12	we	we	PRON
dpc-3965	45	13	imposed	impose	VERB
dpc-3965	45	14	specific	specific	ADJ
dpc-3965	45	15	criteria	criterion	NOUN
dpc-3965	45	16	that	that	PRON
dpc-3965	45	17	required	require	VERB
dpc-3965	45	18	the	the	DET
dpc-3965	45	19	inclusion	inclusion	NOUN
dpc-3965	45	20	of	of	ADP
dpc-3965	45	21	english	english	PROPN
dpc-3965	45	22	-	-	PUNCT
dpc-3965	45	23	written	write	VERB
dpc-3965	45	24	articles	article	NOUN
dpc-3965	45	25	relating	relate	VERB
dpc-3965	45	26	to	to	ADP
dpc-3965	45	27	this	this	DET
dpc-3965	45	28	topic	topic	NOUN
dpc-3965	45	29	published	publish	VERB
dpc-3965	45	30	between	between	ADP
dpc-3965	45	31	2013	2013	NUM
dpc-3965	45	32	and	and	CCONJ
dpc-3965	45	33	2023	2023	NUM
dpc-3965	45	34	.	.	PUNCT
dpc-3965	46	1	this	this	DET
dpc-3965	46	2	timeframe	timeframe	NOUN
dpc-3965	46	3	was	be	AUX
dpc-3965	46	4	chosen	choose	VERB
dpc-3965	46	5	to	to	PART
dpc-3965	46	6	encompass	encompass	VERB
dpc-3965	46	7	the	the	DET
dpc-3965	46	8	most	most	ADV
dpc-3965	46	9	recent	recent	ADJ
dpc-3965	46	10	and	and	CCONJ
dpc-3965	46	11	up	up	ADP
dpc-3965	46	12	-	-	PUNCT
dpc-3965	46	13	to	to	ADP
dpc-3965	46	14	-	-	PUNCT
dpc-3965	46	15	date	date	NOUN
dpc-3965	46	16	research	research	NOUN
dpc-3965	46	17	on	on	ADP
dpc-3965	46	18	hyaluronidase	hyaluronidase	NOUN
dpc-3965	46	19	in	in	ADP
dpc-3965	46	20	the	the	DET
dpc-3965	46	21	context	context	NOUN
dpc-3965	46	22	of	of	ADP
dpc-3965	46	23	ssc	ssc	PROPN
dpc-3965	46	24	.	.	PUNCT
dpc-3965	47	1	studies	study	NOUN
dpc-3965	47	2	conducted	conduct	VERB
dpc-3965	47	3	on	on	ADP
dpc-3965	47	4	human	human	ADJ
dpc-3965	47	5	subjects	subject	NOUN
dpc-3965	47	6	or	or	CCONJ
dpc-3965	47	7	in	in	ADP
dpc-3965	47	8	vitro	vitro	X
dpc-3965	47	9	on	on	ADP
dpc-3965	47	10	human	human	ADJ
dpc-3965	47	11	cell	cell	NOUN
dpc-3965	47	12	lines	line	NOUN
dpc-3965	47	13	were	be	AUX
dpc-3965	47	14	included	include	VERB
dpc-3965	47	15	as	as	ADV
dpc-3965	47	16	well	well	ADV
dpc-3965	47	17	.	.	PUNCT
dpc-3965	48	1	we	we	PRON
dpc-3965	48	2	also	also	ADV
dpc-3965	48	3	applied	apply	VERB
dpc-3965	48	4	exclusion	exclusion	NOUN
dpc-3965	48	5	criteria	criterion	NOUN
dpc-3965	48	6	to	to	PART
dpc-3965	48	7	eliminate	eliminate	VERB
dpc-3965	48	8	articles	article	NOUN
dpc-3965	48	9	that	that	PRON
dpc-3965	48	10	did	do	AUX
dpc-3965	48	11	not	not	PART
dpc-3965	48	12	align	align	VERB
dpc-3965	48	13	with	with	ADP
dpc-3965	48	14	our	our	PRON
dpc-3965	48	15	specific	specific	ADJ
dpc-3965	48	16	research	research	NOUN
dpc-3965	48	17	goals	goal	NOUN
dpc-3965	48	18	.	.	PUNCT
dpc-3965	49	1	articles	article	NOUN
dpc-3965	49	2	outside	outside	ADP
dpc-3965	49	3	the	the	DET
dpc-3965	49	4	defined	define	VERB
dpc-3965	49	5	publication	publication	NOUN
dpc-3965	49	6	date	date	NOUN
dpc-3965	49	7	range	range	NOUN
dpc-3965	49	8	or	or	CCONJ
dpc-3965	49	9	published	publish	VERB
dpc-3965	49	10	in	in	ADP
dpc-3965	49	11	languages	language	NOUN
dpc-3965	49	12	other	other	ADJ
dpc-3965	49	13	than	than	ADP
dpc-3965	49	14	english	english	PROPN
dpc-3965	49	15	were	be	AUX
dpc-3965	49	16	excluded	exclude	VERB
dpc-3965	49	17	to	to	PART
dpc-3965	49	18	maintain	maintain	VERB
dpc-3965	49	19	timeliness	timeliness	NOUN
dpc-3965	49	20	and	and	CCONJ
dpc-3965	49	21	accessibility	accessibility	NOUN
dpc-3965	49	22	of	of	ADP
dpc-3965	49	23	the	the	DET
dpc-3965	49	24	data	datum	NOUN
dpc-3965	49	25	.	.	PUNCT
dpc-3965	50	1	articles	article	NOUN
dpc-3965	50	2	that	that	PRON
dpc-3965	50	3	did	do	AUX
dpc-3965	50	4	not	not	PART
dpc-3965	50	5	discuss	discuss	VERB
dpc-3965	50	6	therapeutic	therapeutic	ADJ
dpc-3965	50	7	use	use	NOUN
dpc-3965	50	8	,	,	PUNCT
dpc-3965	50	9	or	or	CCONJ
dpc-3965	50	10	had	have	VERB
dpc-3965	50	11	results	result	NOUN
dpc-3965	50	12	based	base	VERB
dpc-3965	50	13	on	on	ADP
dpc-3965	50	14	animal	animal	NOUN
dpc-3965	50	15	models	model	NOUN
dpc-3965	50	16	were	be	AUX
dpc-3965	50	17	excluded	exclude	VERB
dpc-3965	50	18	.	.	PUNCT
dpc-3965	51	1	moreover	moreover	ADV
dpc-3965	51	2	,	,	PUNCT
dpc-3965	51	3	we	we	PRON
dpc-3965	51	4	excluded	exclude	VERB
dpc-3965	51	5	articles	article	NOUN
dpc-3965	51	6	that	that	PRON
dpc-3965	51	7	focused	focus	VERB
dpc-3965	51	8	on	on	ADP
dpc-3965	51	9	conditions	condition	NOUN
dpc-3965	51	10	such	such	ADJ
dpc-3965	51	11	as	as	ADP
dpc-3965	51	12	externally	externally	ADV
dpc-3965	51	13	-	-	PUNCT
dpc-3965	51	14	induced	induce	VERB
dpc-3965	51	15	morphea	morphea	NOUN
dpc-3965	51	16	,	,	PUNCT
dpc-3965	51	17	scleredema	scleredema	NOUN
dpc-3965	51	18	,	,	PUNCT
dpc-3965	51	19	scleromyxedema	scleromyxedema	ADV
dpc-3965	51	20	,	,	PUNCT
dpc-3965	51	21	mixed	mixed	ADJ
dpc-3965	51	22	connective	connective	ADJ
dpc-3965	51	23	tissue	tissue	NOUN
dpc-3965	51	24	disease	disease	NOUN
dpc-3965	51	25	(	(	PUNCT
dpc-3965	51	26	mtcd	mtcd	NOUN
dpc-3965	51	27	)	)	PUNCT
dpc-3965	51	28	,	,	PUNCT
dpc-3965	51	29	or	or	CCONJ
dpc-3965	51	30	oral	oral	ADJ
dpc-3965	51	31	submucous	submucous	ADJ
dpc-3965	51	32	fibrosis	fibrosis	NOUN
dpc-3965	51	33	if	if	SCONJ
dpc-3965	51	34	they	they	PRON
dpc-3965	51	35	were	be	AUX
dpc-3965	51	36	unrelated	unrelated	ADJ
dpc-3965	51	37	to	to	ADP
dpc-3965	51	38	the	the	DET
dpc-3965	51	39	underlying	underlie	VERB
dpc-3965	51	40	ssc	ssc	NOUN
dpc-3965	51	41	.	.	PUNCT
dpc-3965	52	1	studies	study	NOUN
dpc-3965	52	2	that	that	PRON
dpc-3965	52	3	evaluated	evaluate	VERB
dpc-3965	52	4	hylaronidase	hylaronidase	NOUN
dpc-3965	52	5	in	in	ADP
dpc-3965	52	6	a	a	DET
dpc-3965	52	7	mixed	mixed	ADJ
dpc-3965	52	8	cohort	cohort	NOUN
dpc-3965	52	9	of	of	ADP
dpc-3965	52	10	diseases	disease	NOUN
dpc-3965	52	11	were	be	AUX
dpc-3965	52	12	only	only	ADV
dpc-3965	52	13	included	include	VERB
dpc-3965	52	14	if	if	SCONJ
dpc-3965	52	15	the	the	DET
dpc-3965	52	16	majority	majority	NOUN
dpc-3965	52	17	of	of	ADP
dpc-3965	52	18	patients	patient	NOUN
dpc-3965	52	19	recruited	recruit	VERB
dpc-3965	52	20	(	(	PUNCT
dpc-3965	52	21	≥	≥	NUM
dpc-3965	52	22	75	75	NUM
dpc-3965	52	23	%	%	NOUN
dpc-3965	52	24	)	)	PUNCT
dpc-3965	52	25	had	have	VERB
dpc-3965	52	26	ssc	ssc	NOUN
dpc-3965	52	27	-	-	PUNCT
dpc-3965	52	28	related	relate	VERB
dpc-3965	52	29	microstomia	microstomia	NOUN
dpc-3965	52	30	.	.	PUNCT
dpc-3965	53	1	bias	bias	NOUN
dpc-3965	53	2	in	in	ADP
dpc-3965	53	3	our	our	PRON
dpc-3965	53	4	search	search	NOUN
dpc-3965	53	5	included	include	VERB
dpc-3965	53	6	selection	selection	NOUN
dpc-3965	53	7	,	,	PUNCT
dpc-3965	53	8	language	language	NOUN
dpc-3965	53	9	,	,	PUNCT
dpc-3965	53	10	and	and	CCONJ
dpc-3965	53	11	publication	publication	NOUN
dpc-3965	53	12	bias	bias	NOUN
dpc-3965	53	13	.	.	PUNCT
dpc-3965	54	1	our	our	PRON
dpc-3965	54	2	results	result	NOUN
dpc-3965	54	3	were	be	AUX
dpc-3965	54	4	limited	limit	VERB
dpc-3965	54	5	to	to	ADP
dpc-3965	54	6	articles	article	NOUN
dpc-3965	54	7	found	find	VERB
dpc-3965	54	8	in	in	ADP
dpc-3965	54	9	pubmed	pubmed	PROPN
dpc-3965	54	10	and	and	CCONJ
dpc-3965	54	11	embase	embase	NOUN
dpc-3965	54	12	,	,	PUNCT
dpc-3965	54	13	however	however	ADV
dpc-3965	54	14	,	,	PUNCT
dpc-3965	54	15	these	these	DET
dpc-3965	54	16	databases	database	NOUN
dpc-3965	54	17	were	be	AUX
dpc-3965	54	18	used	use	VERB
dpc-3965	54	19	due	due	ADP
dpc-3965	54	20	to	to	ADP
dpc-3965	54	21	their	their	PRON
dpc-3965	54	22	focus	focus	NOUN
dpc-3965	54	23	on	on	ADP
dpc-3965	54	24	clinical	clinical	ADJ
dpc-3965	54	25	studies	study	NOUN
dpc-3965	54	26	.	.	PUNCT
dpc-3965	55	1	only	only	ADV
dpc-3965	55	2	english	english	ADJ
dpc-3965	55	3	articles	article	NOUN
dpc-3965	55	4	were	be	AUX
dpc-3965	55	5	included	include	VERB
dpc-3965	55	6	which	which	PRON
dpc-3965	55	7	limited	limit	VERB
dpc-3965	55	8	our	our	PRON
dpc-3965	55	9	results	result	NOUN
dpc-3965	55	10	.	.	PUNCT
dpc-3965	56	1	english	english	ADJ
dpc-3965	56	2	translations	translation	NOUN
dpc-3965	56	3	of	of	ADP
dpc-3965	56	4	studies	study	NOUN
dpc-3965	56	5	first	first	ADV
dpc-3965	56	6	published	publish	VERB
dpc-3965	56	7	in	in	ADP
dpc-3965	56	8	other	other	ADJ
dpc-3965	56	9	languages	language	NOUN
dpc-3965	56	10	were	be	AUX
dpc-3965	56	11	retrieved	retrieve	VERB
dpc-3965	56	12	when	when	SCONJ
dpc-3965	56	13	possible	possible	ADJ
dpc-3965	56	14	.	.	PUNCT
dpc-3965	57	1	lastly	lastly	ADV
dpc-3965	57	2	,	,	PUNCT
dpc-3965	57	3	we	we	PRON
dpc-3965	57	4	acknowledge	acknowledge	VERB
dpc-3965	57	5	publication	publication	NOUN
dpc-3965	57	6	bias	bias	NOUN
dpc-3965	57	7	may	may	AUX
dpc-3965	57	8	have	have	AUX
dpc-3965	57	9	limited	limit	VERB
dpc-3965	57	10	the	the	DET
dpc-3965	57	11	number	number	NOUN
dpc-3965	57	12	of	of	ADP
dpc-3965	57	13	searches	search	NOUN
dpc-3965	57	14	we	we	PRON
dpc-3965	57	15	found	find	VERB
dpc-3965	57	16	in	in	ADP
dpc-3965	57	17	both	both	DET
dpc-3965	57	18	databases	database	NOUN
dpc-3965	57	19	.	.	PUNCT
dpc-3965	58	1	bias	bias	NOUN
dpc-3965	58	2	was	be	AUX
dpc-3965	58	3	assessed	assess	VERB
dpc-3965	58	4	in	in	ADP
dpc-3965	58	5	the	the	DET
dpc-3965	58	6	studies	study	NOUN
dpc-3965	58	7	by	by	ADP
dpc-3965	58	8	identifying	identify	VERB
dpc-3965	58	9	biases	bias	NOUN
dpc-3965	58	10	due	due	ADP
dpc-3965	58	11	to	to	ADP
dpc-3965	58	12	randomization	randomization	NOUN
dpc-3965	58	13	bias	bias	NOUN
dpc-3965	58	14	,	,	PUNCT
dpc-3965	58	15	bias	bias	NOUN
dpc-3965	58	16	from	from	ADP
dpc-3965	58	17	missing	miss	VERB
dpc-3965	58	18	outcome	outcome	NOUN
dpc-3965	58	19	data	datum	NOUN
dpc-3965	58	20	,	,	PUNCT
dpc-3965	58	21	and	and	CCONJ
dpc-3965	58	22	biases	bias	NOUN
dpc-3965	58	23	in	in	ADP
dpc-3965	58	24	outcome	outcome	NOUN
dpc-3965	58	25	measurement	measurement	NOUN
dpc-3965	58	26	.	.	PUNCT
dpc-3965	59	1	results	result	NOUN
dpc-3965	59	2	in	in	ADP
dpc-3965	59	3	this	this	DET
dpc-3965	59	4	section	section	NOUN
dpc-3965	59	5	,	,	PUNCT
dpc-3965	59	6	we	we	PRON
dpc-3965	59	7	present	present	VERB
dpc-3965	59	8	the	the	DET
dpc-3965	59	9	findings	finding	NOUN
dpc-3965	59	10	obtained	obtain	VERB
dpc-3965	59	11	from	from	ADP
dpc-3965	59	12	our	our	PRON
dpc-3965	59	13	data	datum	NOUN
dpc-3965	59	14	analysis	analysis	NOUN
dpc-3965	59	15	,	,	PUNCT
dpc-3965	59	16	providing	provide	VERB
dpc-3965	59	17	a	a	DET
dpc-3965	59	18	thorough	thorough	ADJ
dpc-3965	59	19	review	review	NOUN
dpc-3965	59	20	of	of	ADP
dpc-3965	59	21	each	each	DET
dpc-3965	59	22	study	study	NOUN
dpc-3965	59	23	outcomes	outcome	NOUN
dpc-3965	59	24	to	to	PART
dpc-3965	59	25	highlight	highlight	VERB
dpc-3965	59	26	the	the	DET
dpc-3965	59	27	potential	potential	ADJ
dpc-3965	59	28	advantages	advantage	NOUN
dpc-3965	59	29	of	of	ADP
dpc-3965	59	30	hyaluronidase	hyaluronidase	NOUN
dpc-3965	59	31	injections	injection	NOUN
dpc-3965	59	32	to	to	PART
dpc-3965	59	33	address	address	VERB
dpc-3965	59	34	the	the	DET
dpc-3965	59	35	discomforting	discomforting	NOUN
dpc-3965	59	36	symptoms	symptom	NOUN
dpc-3965	59	37	of	of	ADP
dpc-3965	59	38	ssc	ssc	NOUN
dpc-3965	59	39	,	,	PUNCT
dpc-3965	59	40	particularly	particularly	ADV
dpc-3965	59	41	microstomia	microstomia	ADJ
dpc-3965	59	42	.	.	PUNCT
dpc-3965	60	1	our	our	PRON
dpc-3965	60	2	findings	finding	NOUN
dpc-3965	60	3	consistently	consistently	ADV
dpc-3965	60	4	suggest	suggest	VERB
dpc-3965	60	5	that	that	SCONJ
dpc-3965	60	6	hyaluronidase	hyaluronidase	PROPN
dpc-3965	60	7	administration	administration	NOUN
dpc-3965	60	8	leads	lead	VERB
dpc-3965	60	9	to	to	ADP
dpc-3965	60	10	a	a	DET
dpc-3965	60	11	simultaneous	simultaneous	ADJ
dpc-3965	60	12	improvement	improvement	NOUN
dpc-3965	60	13	of	of	ADP
dpc-3965	60	14	skin	skin	NOUN
dpc-3965	60	15	elasticity	elasticity	NOUN
dpc-3965	60	16	and	and	CCONJ
dpc-3965	60	17	reduction	reduction	NOUN
dpc-3965	60	18	in	in	ADP
dpc-3965	60	19	dermal	dermal	ADJ
dpc-3965	60	20	review	review	NOUN
dpc-3965	60	21	|	|	ADV
dpc-3965	60	22	dermatol	dermatol	ADJ
dpc-3965	60	23	pract	pract	NOUN
dpc-3965	60	24	concept	concept	NOUN
dpc-3965	60	25	.	.	PUNCT
dpc-3965	61	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	61	2	3	3	NUM
dpc-3965	61	3	thickness	thickness	NOUN
dpc-3965	61	4	,	,	PUNCT
dpc-3965	61	5	thereby	thereby	ADV
dpc-3965	61	6	contributing	contribute	VERB
dpc-3965	61	7	to	to	ADP
dpc-3965	61	8	a	a	DET
dpc-3965	61	9	significant	significant	ADJ
dpc-3965	61	10	reduction	reduction	NOUN
dpc-3965	61	11	in	in	ADP
dpc-3965	61	12	some	some	PRON
dpc-3965	61	13	of	of	ADP
dpc-3965	61	14	the	the	DET
dpc-3965	61	15	more	more	ADV
dpc-3965	61	16	distressing	distressing	ADJ
dpc-3965	61	17	aspects	aspect	NOUN
dpc-3965	61	18	of	of	ADP
dpc-3965	61	19	the	the	DET
dpc-3965	61	20	condition	condition	NOUN
dpc-3965	61	21	.	.	PUNCT
dpc-3965	62	1	notably	notably	ADV
dpc-3965	62	2	,	,	PUNCT
dpc-3965	62	3	no	no	DET
dpc-3965	62	4	consistent	consistent	ADJ
dpc-3965	62	5	formulation	formulation	NOUN
dpc-3965	62	6	of	of	ADP
dpc-3965	62	7	hyaluronidase	hyaluronidase	NOUN
dpc-3965	62	8	or	or	CCONJ
dpc-3965	62	9	method	method	NOUN
dpc-3965	62	10	of	of	ADP
dpc-3965	62	11	injection	injection	NOUN
dpc-3965	62	12	was	be	AUX
dpc-3965	62	13	seen	see	VERB
dpc-3965	62	14	throughout	throughout	ADP
dpc-3965	62	15	therapeutic	therapeutic	ADJ
dpc-3965	62	16	reports	report	NOUN
dpc-3965	62	17	.	.	PUNCT
dpc-3965	63	1	a	a	DET
dpc-3965	63	2	summary	summary	NOUN
dpc-3965	63	3	of	of	ADP
dpc-3965	63	4	key	key	ADJ
dpc-3965	63	5	findings	finding	NOUN
dpc-3965	63	6	and	and	CCONJ
dpc-3965	63	7	methodology	methodology	NOUN
dpc-3965	63	8	from	from	ADP
dpc-3965	63	9	all	all	DET
dpc-3965	63	10	cases	case	NOUN
dpc-3965	63	11	assessed	assess	VERB
dpc-3965	63	12	in	in	ADP
dpc-3965	63	13	our	our	PRON
dpc-3965	63	14	review	review	NOUN
dpc-3965	63	15	is	be	AUX
dpc-3965	63	16	provided	provide	VERB
dpc-3965	63	17	in	in	ADP
dpc-3965	63	18	table	table	NOUN
dpc-3965	63	19	1	1	NUM
dpc-3965	63	20	.	.	PUNCT
dpc-3965	64	1	in	in	ADP
dpc-3965	64	2	vitro	vitro	X
dpc-3965	64	3	a	a	DET
dpc-3965	64	4	2015	2015	NUM
dpc-3965	64	5	study	study	NOUN
dpc-3965	64	6	by	by	ADP
dpc-3965	64	7	kilic	kilic	PROPN
dpc-3965	64	8	et	et	PROPN
dpc-3965	64	9	al	al	PROPN
dpc-3965	64	10	analyzed	analyze	VERB
dpc-3965	64	11	the	the	DET
dpc-3965	64	12	levels	level	NOUN
dpc-3965	64	13	of	of	ADP
dpc-3965	64	14	hyaluronan	hyaluronan	PROPN
dpc-3965	64	15	and	and	CCONJ
dpc-3965	64	16	hyaluronidase	hyaluronidase	ADJ
dpc-3965	64	17	activation	activation	NOUN
dpc-3965	64	18	in	in	ADP
dpc-3965	64	19	dermal	dermal	ADJ
dpc-3965	64	20	tissue	tissue	NOUN
dpc-3965	64	21	of	of	ADP
dpc-3965	64	22	patients	patient	NOUN
dpc-3965	64	23	with	with	ADP
dpc-3965	64	24	ssc	ssc	PROPN
dpc-3965	65	1	[	[	X
dpc-3965	65	2	7	7	NUM
dpc-3965	65	3	]	]	PUNCT
dpc-3965	65	4	.	.	PUNCT
dpc-3965	66	1	hyaluronan	hyaluronan	PROPN
dpc-3965	66	2	is	be	AUX
dpc-3965	66	3	a	a	DET
dpc-3965	66	4	glycosaminoglycan	glycosaminoglycan	NOUN
dpc-3965	66	5	,	,	PUNCT
dpc-3965	66	6	a	a	DET
dpc-3965	66	7	major	major	ADJ
dpc-3965	66	8	component	component	NOUN
dpc-3965	66	9	of	of	ADP
dpc-3965	66	10	the	the	DET
dpc-3965	66	11	extracellular	extracellular	ADJ
dpc-3965	66	12	matrix	matrix	NOUN
dpc-3965	66	13	,	,	PUNCT
dpc-3965	66	14	and	and	CCONJ
dpc-3965	66	15	is	be	AUX
dpc-3965	66	16	involved	involve	VERB
dpc-3965	66	17	in	in	ADP
dpc-3965	66	18	initiating	initiate	VERB
dpc-3965	66	19	the	the	DET
dpc-3965	66	20	inflammatory	inflammatory	ADJ
dpc-3965	66	21	process	process	NOUN
dpc-3965	66	22	and	and	CCONJ
dpc-3965	66	23	remodeling	remodeling	NOUN
dpc-3965	66	24	after	after	ADP
dpc-3965	66	25	tissue	tissue	NOUN
dpc-3965	66	26	damage	damage	NOUN
dpc-3965	66	27	.	.	PUNCT
dpc-3965	67	1	the	the	DET
dpc-3965	67	2	enzyme	enzyme	NOUN
dpc-3965	67	3	hyaluronan	hyaluronan	NOUN
dpc-3965	67	4	synthase	synthase	NOUN
dpc-3965	67	5	is	be	AUX
dpc-3965	67	6	responsible	responsible	ADJ
dpc-3965	67	7	for	for	ADP
dpc-3965	67	8	building	build	VERB
dpc-3965	67	9	this	this	DET
dpc-3965	67	10	polymer	polymer	NOUN
dpc-3965	67	11	,	,	PUNCT
dpc-3965	67	12	while	while	SCONJ
dpc-3965	67	13	hyaluronidase	hyaluronidase	NOUN
dpc-3965	67	14	degrades	degrade	VERB
dpc-3965	67	15	it	it	PRON
dpc-3965	67	16	.	.	PUNCT
dpc-3965	68	1	the	the	DET
dpc-3965	68	2	study	study	NOUN
dpc-3965	68	3	found	find	VERB
dpc-3965	68	4	significantly	significantly	ADV
dpc-3965	68	5	increased	increase	VERB
dpc-3965	68	6	levels	level	NOUN
dpc-3965	68	7	and	and	CCONJ
dpc-3965	68	8	density	density	NOUN
dpc-3965	68	9	of	of	ADP
dpc-3965	68	10	hyaluronan	hyaluronan	PROPN
dpc-3965	68	11	in	in	ADP
dpc-3965	68	12	ssc	ssc	PROPN
dpc-3965	68	13	patients	patient	NOUN
dpc-3965	68	14	with	with	ADP
dpc-3965	68	15	cutaneous	cutaneous	ADJ
dpc-3965	68	16	involvement	involvement	NOUN
dpc-3965	68	17	.	.	PUNCT
dpc-3965	69	1	the	the	DET
dpc-3965	69	2	authors	author	NOUN
dpc-3965	69	3	noted	note	VERB
dpc-3965	69	4	patients	patient	NOUN
dpc-3965	69	5	with	with	ADP
dpc-3965	69	6	ssc	ssc	PROPN
dpc-3965	69	7	had	have	VERB
dpc-3965	69	8	increased	increase	VERB
dpc-3965	69	9	activity	activity	NOUN
dpc-3965	69	10	levels	level	NOUN
dpc-3965	69	11	of	of	ADP
dpc-3965	69	12	hyaluronan	hyaluronan	PROPN
dpc-3965	69	13	synthase-2	synthase-2	NUM
dpc-3965	69	14	and	and	CCONJ
dpc-3965	69	15	decreased	decrease	VERB
dpc-3965	69	16	activity	activity	NOUN
dpc-3965	69	17	of	of	ADP
dpc-3965	69	18	hyaluronidase-2	hyaluronidase-2	NUM
dpc-3965	69	19	in	in	ADP
dpc-3965	69	20	patients	patient	NOUN
dpc-3965	69	21	versus	versus	ADP
dpc-3965	69	22	healthy	healthy	ADJ
dpc-3965	69	23	controls	control	NOUN
dpc-3965	69	24	[	[	X
dpc-3965	69	25	7	7	NUM
dpc-3965	69	26	]	]	PUNCT
dpc-3965	69	27	.	.	PUNCT
dpc-3965	70	1	case	case	NOUN
dpc-3965	70	2	reports	report	VERB
dpc-3965	70	3	three	three	NUM
dpc-3965	70	4	recent	recent	ADJ
dpc-3965	70	5	case	case	NOUN
dpc-3965	70	6	reports	report	NOUN
dpc-3965	70	7	were	be	AUX
dpc-3965	70	8	published	publish	VERB
dpc-3965	70	9	detailing	detail	VERB
dpc-3965	70	10	the	the	DET
dpc-3965	70	11	therapeutic	therapeutic	ADJ
dpc-3965	70	12	use	use	NOUN
dpc-3965	70	13	of	of	ADP
dpc-3965	70	14	hyaluronidase	hyaluronidase	NOUN
dpc-3965	70	15	in	in	ADP
dpc-3965	70	16	ssc	ssc	PROPN
dpc-3965	70	17	.	.	PUNCT
dpc-3965	71	1	in	in	ADP
dpc-3965	71	2	one	one	NUM
dpc-3965	71	3	case	case	NOUN
dpc-3965	71	4	report	report	NOUN
dpc-3965	71	5	involving	involve	VERB
dpc-3965	71	6	a	a	DET
dpc-3965	71	7	30	30	NUM
dpc-3965	71	8	year	year	NOUN
dpc-3965	71	9	-	-	PUNCT
dpc-3965	71	10	old	old	ADJ
dpc-3965	71	11	female	female	ADJ
dpc-3965	71	12	patient	patient	NOUN
dpc-3965	71	13	with	with	ADP
dpc-3965	71	14	diffuse	diffuse	PROPN
dpc-3965	71	15	ssc	ssc	PROPN
dpc-3965	71	16	,	,	PUNCT
dpc-3965	71	17	hyaluronidase	hyaluronidase	NOUN
dpc-3965	71	18	injections	injection	NOUN
dpc-3965	71	19	proved	prove	VERB
dpc-3965	71	20	to	to	PART
dpc-3965	71	21	be	be	AUX
dpc-3965	71	22	successful	successful	ADJ
dpc-3965	71	23	in	in	ADP
dpc-3965	71	24	improving	improve	VERB
dpc-3965	71	25	discomfort	discomfort	NOUN
dpc-3965	71	26	and	and	CCONJ
dpc-3965	71	27	overall	overall	ADJ
dpc-3965	71	28	self	self	NOUN
dpc-3965	71	29	-	-	PUNCT
dpc-3965	71	30	image	image	NOUN
dpc-3965	71	31	[	[	X
dpc-3965	71	32	9	9	NUM
dpc-3965	71	33	]	]	PUNCT
dpc-3965	71	34	.	.	PUNCT
dpc-3965	72	1	she	she	PRON
dpc-3965	72	2	presented	present	VERB
dpc-3965	72	3	with	with	ADP
dpc-3965	72	4	increased	increase	VERB
dpc-3965	72	5	tautness	tautness	NOUN
dpc-3965	72	6	in	in	ADP
dpc-3965	72	7	the	the	DET
dpc-3965	72	8	perioral	perioral	ADJ
dpc-3965	72	9	and	and	CCONJ
dpc-3965	72	10	periocular	periocular	ADJ
dpc-3965	72	11	regions	region	NOUN
dpc-3965	72	12	,	,	PUNCT
dpc-3965	72	13	along	along	ADP
dpc-3965	72	14	with	with	ADP
dpc-3965	72	15	functional	functional	ADJ
dpc-3965	72	16	impairments	impairment	NOUN
dpc-3965	72	17	in	in	ADP
dpc-3965	72	18	mastication	mastication	NOUN
dpc-3965	72	19	,	,	PUNCT
dpc-3965	72	20	phonation	phonation	NOUN
dpc-3965	72	21	,	,	PUNCT
dpc-3965	72	22	and	and	CCONJ
dpc-3965	72	23	sleep	sleep	NOUN
dpc-3965	72	24	.	.	PUNCT
dpc-3965	73	1	despite	despite	SCONJ
dpc-3965	73	2	her	her	PRON
dpc-3965	73	3	ongoing	ongoing	ADJ
dpc-3965	73	4	treatment	treatment	NOUN
dpc-3965	73	5	regimen	regiman	NOUN
dpc-3965	73	6	with	with	ADP
dpc-3965	73	7	mycophenolate	mycophenolate	PROPN
dpc-3965	73	8	mofetil	mofetil	PROPN
dpc-3965	73	9	,	,	PUNCT
dpc-3965	73	10	hydroxychloroquine	hydroxychloroquine	PROPN
dpc-3965	73	11	,	,	PUNCT
dpc-3965	73	12	sildenafil	sildenafil	NOUN
dpc-3965	73	13	,	,	PUNCT
dpc-3965	73	14	nintedanib	nintedanib	NOUN
dpc-3965	73	15	,	,	PUNCT
dpc-3965	73	16	and	and	CCONJ
dpc-3965	73	17	prednisone	prednisone	NOUN
dpc-3965	73	18	,	,	PUNCT
dpc-3965	73	19	she	she	PRON
dpc-3965	73	20	experienced	experience	VERB
dpc-3965	73	21	no	no	DET
dpc-3965	73	22	relief	relief	NOUN
dpc-3965	73	23	from	from	ADP
dpc-3965	73	24	her	her	PRON
dpc-3965	73	25	microstomia	microstomia	NOUN
dpc-3965	73	26	and	and	CCONJ
dpc-3965	73	27	therefore	therefore	ADV
dpc-3965	73	28	decided	decide	VERB
dpc-3965	73	29	to	to	PART
dpc-3965	73	30	undergo	undergo	VERB
dpc-3965	73	31	a	a	DET
dpc-3965	73	32	trial	trial	NOUN
dpc-3965	73	33	of	of	ADP
dpc-3965	73	34	intradermal	intradermal	ADJ
dpc-3965	73	35	hyaluronidase	hyaluronidase	NOUN
dpc-3965	73	36	.	.	PUNCT
dpc-3965	74	1	following	follow	VERB
dpc-3965	74	2	the	the	DET
dpc-3965	74	3	administration	administration	NOUN
dpc-3965	74	4	of	of	ADP
dpc-3965	74	5	150	150	NUM
dpc-3965	74	6	units	unit	NOUN
dpc-3965	74	7	of	of	ADP
dpc-3965	74	8	recombinant	recombinant	ADJ
dpc-3965	74	9	human	human	ADJ
dpc-3965	74	10	hyaluronidase	hyaluronidase	NOUN
dpc-3965	74	11	(	(	PUNCT
dpc-3965	74	12	0.1	0.1	NUM
dpc-3965	74	13	ml	ml	NOUN
dpc-3965	74	14	per	per	ADP
dpc-3965	74	15	injection	injection	NOUN
dpc-3965	74	16	)	)	PUNCT
dpc-3965	74	17	,	,	PUNCT
dpc-3965	74	18	she	she	PRON
dpc-3965	74	19	experienced	experience	VERB
dpc-3965	74	20	an	an	DET
dpc-3965	74	21	improvement	improvement	NOUN
dpc-3965	74	22	in	in	ADP
dpc-3965	74	23	daily	daily	ADJ
dpc-3965	74	24	function	function	NOUN
dpc-3965	74	25	and	and	CCONJ
dpc-3965	74	26	cosmetic	cosmetic	ADJ
dpc-3965	74	27	appearance	appearance	NOUN
dpc-3965	74	28	.	.	PUNCT
dpc-3965	75	1	after	after	ADP
dpc-3965	75	2	three	three	NUM
dpc-3965	75	3	months	month	NOUN
dpc-3965	75	4	,	,	PUNCT
dpc-3965	75	5	her	her	PRON
dpc-3965	75	6	oral	oral	ADJ
dpc-3965	75	7	aperture	aperture	NOUN
dpc-3965	75	8	had	have	AUX
dpc-3965	75	9	expanded	expand	VERB
dpc-3965	75	10	to	to	ADP
dpc-3965	75	11	15.2	15.2	NUM
dpc-3965	75	12	cm	cm	NOUN
dpc-3965	75	13	from	from	ADP
dpc-3965	75	14	13.7	13.7	NUM
dpc-3965	75	15	cm	cm	NOUN
dpc-3965	75	16	prior	prior	ADV
dpc-3965	75	17	to	to	ADP
dpc-3965	75	18	the	the	DET
dpc-3965	75	19	injections	injection	NOUN
dpc-3965	75	20	[	[	X
dpc-3965	75	21	9	9	NUM
dpc-3965	75	22	]	]	PUNCT
dpc-3965	75	23	.	.	PUNCT
dpc-3965	76	1	the	the	DET
dpc-3965	76	2	use	use	NOUN
dpc-3965	76	3	of	of	ADP
dpc-3965	76	4	hyaluronidase	hyaluronidase	NOUN
dpc-3965	76	5	to	to	PART
dpc-3965	76	6	address	address	VERB
dpc-3965	76	7	microstomia	microstomia	NOUN
dpc-3965	76	8	in	in	ADP
dpc-3965	76	9	this	this	DET
dpc-3965	76	10	patient	patient	ADJ
dpc-3965	76	11	population	population	NOUN
dpc-3965	76	12	is	be	AUX
dpc-3965	76	13	further	far	ADV
dpc-3965	76	14	supported	support	VERB
dpc-3965	76	15	by	by	ADP
dpc-3965	76	16	two	two	NUM
dpc-3965	76	17	cases	case	NOUN
dpc-3965	76	18	,	,	PUNCT
dpc-3965	76	19	advocating	advocate	VERB
dpc-3965	76	20	for	for	ADP
dpc-3965	76	21	its	its	PRON
dpc-3965	76	22	recognition	recognition	NOUN
dpc-3965	76	23	as	as	ADP
dpc-3965	76	24	a	a	DET
dpc-3965	76	25	desirable	desirable	ADJ
dpc-3965	76	26	alternative	alternative	NOUN
dpc-3965	76	27	when	when	SCONJ
dpc-3965	76	28	conventional	conventional	ADJ
dpc-3965	76	29	treatments	treatment	NOUN
dpc-3965	76	30	are	be	AUX
dpc-3965	76	31	refractory	refractory	NOUN
dpc-3965	76	32	.	.	PUNCT
dpc-3965	77	1	in	in	ADP
dpc-3965	77	2	the	the	DET
dpc-3965	77	3	first	first	ADJ
dpc-3965	77	4	case	case	NOUN
dpc-3965	77	5	,	,	PUNCT
dpc-3965	77	6	a	a	DET
dpc-3965	77	7	45	45	NUM
dpc-3965	77	8	-	-	PUNCT
dpc-3965	77	9	year	year	NOUN
dpc-3965	77	10	-	-	PUNCT
dpc-3965	77	11	old	old	ADJ
dpc-3965	77	12	female	female	NOUN
dpc-3965	77	13	with	with	ADP
dpc-3965	77	14	scleroderma	scleroderma	NOUN
dpc-3965	77	15	and	and	CCONJ
dpc-3965	77	16	a	a	DET
dpc-3965	77	17	year	year	NOUN
dpc-3965	77	18	-	-	PUNCT
dpc-3965	77	19	long	long	ADJ
dpc-3965	77	20	complaint	complaint	NOUN
dpc-3965	77	21	of	of	ADP
dpc-3965	77	22	microstomia	microstomia	NOUN
dpc-3965	77	23	received	receive	VERB
dpc-3965	77	24	4	4	NUM
dpc-3965	77	25	mg	mg	NOUN
dpc-3965	77	26	of	of	ADP
dpc-3965	77	27	dexamethasone	dexamethasone	NOUN
dpc-3965	77	28	sodium	sodium	NOUN
dpc-3965	77	29	phosphate	phosphate	NOUN
dpc-3965	77	30	in	in	ADP
dpc-3965	77	31	combination	combination	NOUN
dpc-3965	77	32	with	with	ADP
dpc-3965	77	33	1,500	1,500	NUM
dpc-3965	77	34	units	unit	NOUN
dpc-3965	77	35	of	of	ADP
dpc-3965	77	36	intradermal	intradermal	ADJ
dpc-3965	77	37	hyaluronidase	hyaluronidase	NOUN
dpc-3965	77	38	periorally	periorally	ADV
dpc-3965	77	39	for	for	ADP
dpc-3965	77	40	5	5	NUM
dpc-3965	77	41	months	month	NOUN
dpc-3965	77	42	,	,	PUNCT
dpc-3965	77	43	increasing	increase	VERB
dpc-3965	77	44	her	her	PRON
dpc-3965	77	45	interincisal	interincisal	ADJ
dpc-3965	77	46	distance	distance	NOUN
dpc-3965	77	47	by	by	ADP
dpc-3965	77	48	13	13	NUM
dpc-3965	77	49	mm	mm	NOUN
dpc-3965	77	50	over	over	ADP
dpc-3965	77	51	that	that	DET
dpc-3965	77	52	duration	duration	NOUN
dpc-3965	77	53	[	[	X
dpc-3965	77	54	10	10	NUM
dpc-3965	77	55	]	]	PUNCT
dpc-3965	77	56	.	.	PUNCT
dpc-3965	78	1	the	the	DET
dpc-3965	78	2	second	second	ADJ
dpc-3965	78	3	case	case	NOUN
dpc-3965	78	4	describes	describe	VERB
dpc-3965	78	5	a	a	DET
dpc-3965	78	6	53	53	NUM
dpc-3965	78	7	-	-	PUNCT
dpc-3965	78	8	year	year	NOUN
dpc-3965	78	9	-	-	PUNCT
dpc-3965	78	10	old	old	ADJ
dpc-3965	78	11	female	female	NOUN
dpc-3965	78	12	who	who	PRON
dpc-3965	78	13	experienced	experience	VERB
dpc-3965	78	14	a	a	DET
dpc-3965	78	15	mild	mild	ADJ
dpc-3965	78	16	improvement	improvement	NOUN
dpc-3965	78	17	in	in	ADP
dpc-3965	78	18	the	the	DET
dpc-3965	78	19	mouth	mouth	NOUN
dpc-3965	78	20	handicap	handicap	NOUN
dpc-3965	78	21	in	in	ADP
dpc-3965	78	22	systemic	systemic	ADJ
dpc-3965	78	23	sclerosis	sclerosis	NOUN
dpc-3965	78	24	(	(	PUNCT
dpc-3965	78	25	mhiss	mhiss	ADJ
dpc-3965	78	26	)	)	PUNCT
dpc-3965	78	27	score	score	NOUN
dpc-3965	78	28	after	after	ADP
dpc-3965	78	29	receiving	receive	VERB
dpc-3965	78	30	470	470	NUM
dpc-3965	78	31	units	unit	NOUN
dpc-3965	78	32	of	of	ADP
dpc-3965	78	33	intradermal	intradermal	ADJ
dpc-3965	78	34	hyaluronidase	hyaluronidase	NOUN
dpc-3965	78	35	in	in	ADP
dpc-3965	78	36	her	her	PRON
dpc-3965	78	37	lips	lip	NOUN
dpc-3965	78	38	over	over	ADP
dpc-3965	78	39	7	7	NUM
dpc-3965	78	40	months	month	NOUN
dpc-3965	78	41	[	[	X
dpc-3965	78	42	11	11	NUM
dpc-3965	78	43	]	]	PUNCT
dpc-3965	78	44	.	.	PUNCT
dpc-3965	79	1	case	case	NOUN
dpc-3965	79	2	series	serie	VERB
dpc-3965	79	3	the	the	DET
dpc-3965	79	4	first	first	ADJ
dpc-3965	79	5	case	case	NOUN
dpc-3965	79	6	series	series	NOUN
dpc-3965	79	7	on	on	ADP
dpc-3965	79	8	hyaluronidase	hyaluronidase	NOUN
dpc-3965	79	9	in	in	ADP
dpc-3965	79	10	ssc	ssc	NOUN
dpc-3965	79	11	microstomia	microstomia	NOUN
dpc-3965	79	12	was	be	AUX
dpc-3965	79	13	recently	recently	ADV
dpc-3965	79	14	published	publish	VERB
dpc-3965	79	15	by	by	ADP
dpc-3965	79	16	min	min	PROPN
dpc-3965	79	17	et	et	PROPN
dpc-3965	79	18	al	al	PROPN
dpc-3965	79	19	,	,	PUNCT
dpc-3965	79	20	who	who	PRON
dpc-3965	79	21	reported	report	VERB
dpc-3965	79	22	4	4	NUM
dpc-3965	79	23	patients	patient	NOUN
dpc-3965	79	24	with	with	ADP
dpc-3965	79	25	autoimmune	autoimmune	ADJ
dpc-3965	79	26	sclerosing	sclerose	VERB
dpc-3965	79	27	disease	disease	NOUN
dpc-3965	79	28	,	,	PUNCT
dpc-3965	79	29	3	3	NUM
dpc-3965	79	30	with	with	ADP
dpc-3965	79	31	ssc	ssc	NOUN
dpc-3965	79	32	and	and	CCONJ
dpc-3965	79	33	one	one	NUM
dpc-3965	79	34	with	with	ADP
dpc-3965	79	35	mctd	mctd	NOUN
dpc-3965	79	36	[	[	X
dpc-3965	79	37	12	12	NUM
dpc-3965	79	38	]	]	PUNCT
dpc-3965	79	39	.	.	PUNCT
dpc-3965	80	1	primary	primary	ADJ
dpc-3965	80	2	outcomes	outcome	NOUN
dpc-3965	80	3	included	include	VERB
dpc-3965	80	4	improvements	improvement	NOUN
dpc-3965	80	5	in	in	ADP
dpc-3965	80	6	mouth	mouth	NOUN
dpc-3965	80	7	opening	opening	NOUN
dpc-3965	80	8	capacity	capacity	NOUN
dpc-3965	80	9	(	(	PUNCT
dpc-3965	80	10	moc	moc	NOUN
dpc-3965	80	11	)	)	PUNCT
dpc-3965	80	12	,	,	PUNCT
dpc-3965	80	13	measured	measure	VERB
dpc-3965	80	14	vertically	vertically	ADV
dpc-3965	80	15	in	in	ADP
dpc-3965	80	16	centimeters	centimeter	NOUN
dpc-3965	80	17	from	from	ADP
dpc-3965	80	18	upper	upper	ADJ
dpc-3965	80	19	to	to	ADP
dpc-3965	80	20	lower	low	ADJ
dpc-3965	80	21	vermillion	vermillion	NOUN
dpc-3965	80	22	border	border	NOUN
dpc-3965	80	23	,	,	PUNCT
dpc-3965	80	24	and	and	CCONJ
dpc-3965	80	25	mhiss	mhiss	ADJ
dpc-3965	80	26	.	.	PUNCT
dpc-3965	81	1	this	this	DET
dpc-3965	81	2	study	study	NOUN
dpc-3965	81	3	involved	involve	VERB
dpc-3965	81	4	a	a	DET
dpc-3965	81	5	total	total	NOUN
dpc-3965	81	6	of	of	ADP
dpc-3965	81	7	four	four	NUM
dpc-3965	81	8	patients	patient	NOUN
dpc-3965	81	9	with	with	ADP
dpc-3965	81	10	various	various	ADJ
dpc-3965	81	11	forms	form	NOUN
dpc-3965	81	12	of	of	ADP
dpc-3965	81	13	scleroderma	scleroderma	NOUN
dpc-3965	81	14	:	:	PUNCT
dpc-3965	81	15	two	two	NUM
dpc-3965	81	16	with	with	ADP
dpc-3965	81	17	limited	limited	ADJ
dpc-3965	81	18	ssc	ssc	PROPN
dpc-3965	81	19	,	,	PUNCT
dpc-3965	81	20	one	one	NUM
dpc-3965	81	21	with	with	ADP
dpc-3965	81	22	diffuse	diffuse	PROPN
dpc-3965	81	23	ssc	ssc	PROPN
dpc-3965	81	24	,	,	PUNCT
dpc-3965	81	25	and	and	CCONJ
dpc-3965	81	26	one	one	NUM
dpc-3965	81	27	with	with	ADP
dpc-3965	81	28	mixed	mixed	ADJ
dpc-3965	81	29	connective	connective	ADJ
dpc-3965	81	30	tissue	tissue	NOUN
dpc-3965	81	31	disease	disease	NOUN
dpc-3965	81	32	with	with	ADP
dpc-3965	81	33	sclero	sclero	NOUN
dpc-3965	81	34	-	-	PUNCT
dpc-3965	81	35	dermoid	dermoid	NOUN
dpc-3965	81	36	features	feature	NOUN
dpc-3965	81	37	.	.	PUNCT
dpc-3965	82	1	all	all	DET
dpc-3965	82	2	patients	patient	NOUN
dpc-3965	82	3	experienced	experience	VERB
dpc-3965	82	4	significant	significant	ADJ
dpc-3965	82	5	oral	oral	ADJ
dpc-3965	82	6	microstomia	microstomia	NOUN
dpc-3965	82	7	at	at	ADP
dpc-3965	82	8	the	the	DET
dpc-3965	82	9	start	start	NOUN
dpc-3965	82	10	of	of	ADP
dpc-3965	82	11	the	the	DET
dpc-3965	82	12	study	study	NOUN
dpc-3965	82	13	with	with	ADP
dpc-3965	82	14	a	a	DET
dpc-3965	82	15	baseline	baseline	ADJ
dpc-3965	82	16	moc	moc	NOUN
dpc-3965	82	17	ranging	range	VERB
dpc-3965	82	18	from	from	ADP
dpc-3965	82	19	4.4	4.4	NUM
dpc-3965	82	20	to	to	ADP
dpc-3965	82	21	5.2	5.2	NUM
dpc-3965	82	22	cm	cm	NOUN
dpc-3965	82	23	(	(	PUNCT
dpc-3965	82	24	mean	mean	NOUN
dpc-3965	82	25	4.8	4.8	NUM
dpc-3965	82	26	cm	cm	NOUN
dpc-3965	82	27	)	)	PUNCT
dpc-3965	82	28	and	and	CCONJ
dpc-3965	82	29	mhiss	mhiss	ADJ
dpc-3965	82	30	scores	score	NOUN
dpc-3965	82	31	from	from	ADP
dpc-3965	82	32	24	24	NUM
dpc-3965	82	33	to	to	ADP
dpc-3965	82	34	37	37	NUM
dpc-3965	82	35	(	(	PUNCT
dpc-3965	82	36	mean	mean	PROPN
dpc-3965	82	37	31	31	NUM
dpc-3965	82	38	)	)	PUNCT
dpc-3965	82	39	.	.	PUNCT
dpc-3965	83	1	treatment	treatment	NOUN
dpc-3965	83	2	was	be	AUX
dpc-3965	83	3	standardized	standardize	VERB
dpc-3965	83	4	:	:	PUNCT
dpc-3965	83	5	all	all	DET
dpc-3965	83	6	patients	patient	NOUN
dpc-3965	83	7	received	receive	VERB
dpc-3965	83	8	an	an	DET
dpc-3965	83	9	initial	initial	ADJ
dpc-3965	83	10	treatment	treatment	NOUN
dpc-3965	83	11	of	of	ADP
dpc-3965	83	12	200	200	NUM
dpc-3965	83	13	iu	iu	ADV
dpc-3965	83	14	hyaluronidase	hyaluronidase	NOUN
dpc-3965	83	15	diluted	dilute	VERB
dpc-3965	83	16	in	in	ADP
dpc-3965	83	17	6ml	6ml	ADJ
dpc-3965	83	18	saline	saline	NOUN
dpc-3965	83	19	,	,	PUNCT
dpc-3965	83	20	injected	inject	VERB
dpc-3965	83	21	1	1	NUM
dpc-3965	83	22	cm	cm	NOUN
dpc-3965	83	23	apart	apart	ADV
dpc-3965	83	24	in	in	ADP
dpc-3965	83	25	2	2	NUM
dpc-3965	83	26	rows	row	NOUN
dpc-3965	83	27	all	all	ADV
dpc-3965	83	28	around	around	ADP
dpc-3965	83	29	the	the	DET
dpc-3965	83	30	lip	lip	NOUN
dpc-3965	83	31	.	.	PUNCT
dpc-3965	84	1	monthly	monthly	ADJ
dpc-3965	84	2	follow	follow	NOUN
dpc-3965	84	3	-	-	PUNCT
dpc-3965	84	4	up	up	ADP
dpc-3965	84	5	treatments	treatment	NOUN
dpc-3965	84	6	were	be	AUX
dpc-3965	84	7	provided	provide	VERB
dpc-3965	84	8	,	,	PUNCT
dpc-3965	84	9	of	of	ADP
dpc-3965	84	10	which	which	DET
dpc-3965	84	11	duration	duration	NOUN
dpc-3965	84	12	varied	varied	ADJ
dpc-3965	84	13	per	per	ADP
dpc-3965	84	14	patient	patient	NOUN
dpc-3965	84	15	.	.	PUNCT
dpc-3965	85	1	all	all	DET
dpc-3965	85	2	patients	patient	NOUN
dpc-3965	85	3	showed	show	VERB
dpc-3965	85	4	improvements	improvement	NOUN
dpc-3965	85	5	in	in	ADP
dpc-3965	85	6	both	both	PRON
dpc-3965	85	7	moc	moc	NOUN
dpc-3965	85	8	and	and	CCONJ
dpc-3965	85	9	mhiss	mhiss	NOUN
dpc-3965	85	10	scores	score	NOUN
dpc-3965	85	11	.	.	PUNCT
dpc-3965	86	1	on	on	ADP
dpc-3965	86	2	average	average	ADJ
dpc-3965	86	3	,	,	PUNCT
dpc-3965	86	4	moc	moc	PROPN
dpc-3965	86	5	increased	increase	VERB
dpc-3965	86	6	by	by	ADP
dpc-3965	86	7	0.9	0.9	NUM
dpc-3965	86	8	cm	cm	NOUN
dpc-3965	86	9	(	(	PUNCT
dpc-3965	86	10	19.1	19.1	NUM
dpc-3965	86	11	%	%	NOUN
dpc-3965	86	12	increase	increase	NOUN
dpc-3965	86	13	)	)	PUNCT
dpc-3965	86	14	,	,	PUNCT
dpc-3965	86	15	ranging	range	VERB
dpc-3965	86	16	from	from	ADP
dpc-3965	86	17	0.5	0.5	NUM
dpc-3965	86	18	to	to	ADP
dpc-3965	86	19	1.6	1.6	NUM
dpc-3965	86	20	cm	cm	NOUN
dpc-3965	86	21	(	(	PUNCT
dpc-3965	86	22	11.1	11.1	NUM
dpc-3965	86	23	-	-	SYM
dpc-3965	86	24	36.3	36.3	NUM
dpc-3965	86	25	%	%	NOUN
dpc-3965	86	26	increase	increase	NOUN
dpc-3965	86	27	)	)	PUNCT
dpc-3965	86	28	.	.	PUNCT
dpc-3965	87	1	mhiss	mhiss	ADJ
dpc-3965	87	2	scores	score	NOUN
dpc-3965	87	3	decreased	decrease	VERB
dpc-3965	87	4	by	by	ADP
dpc-3965	87	5	an	an	DET
dpc-3965	87	6	average	average	NOUN
dpc-3965	87	7	of	of	ADP
dpc-3965	87	8	19.3	19.3	NUM
dpc-3965	87	9	(	(	PUNCT
dpc-3965	87	10	61.9	61.9	NUM
dpc-3965	87	11	%	%	NOUN
dpc-3965	87	12	decrease	decrease	NOUN
dpc-3965	87	13	)	)	PUNCT
dpc-3965	87	14	,	,	PUNCT
dpc-3965	87	15	ranging	range	VERB
dpc-3965	87	16	from	from	ADP
dpc-3965	87	17	17	17	NUM
dpc-3965	87	18	to	to	PART
dpc-3965	87	19	24	24	NUM
dpc-3965	87	20	(	(	PUNCT
dpc-3965	87	21	48.4	48.4	NUM
dpc-3965	87	22	to	to	PART
dpc-3965	87	23	70.8	70.8	NUM
dpc-3965	87	24	%	%	NOUN
dpc-3965	87	25	decrease	decrease	NOUN
dpc-3965	87	26	)	)	PUNCT
dpc-3965	87	27	.	.	PUNCT
dpc-3965	88	1	additionally	additionally	ADV
dpc-3965	88	2	,	,	PUNCT
dpc-3965	88	3	perioral	perioral	ADJ
dpc-3965	88	4	skin	skin	NOUN
dpc-3965	88	5	softening	softening	NOUN
dpc-3965	88	6	was	be	AUX
dpc-3965	88	7	observed	observe	VERB
dpc-3965	88	8	in	in	ADP
dpc-3965	88	9	all	all	DET
dpc-3965	88	10	patients	patient	NOUN
dpc-3965	88	11	.	.	PUNCT
dpc-3965	89	1	researchers	researcher	NOUN
dpc-3965	89	2	noted	note	VERB
dpc-3965	89	3	benefits	benefit	NOUN
dpc-3965	89	4	plateaued	plateaue	VERB
dpc-3965	89	5	after	after	ADP
dpc-3965	89	6	3	3	NUM
dpc-3965	89	7	-	-	SYM
dpc-3965	89	8	5	5	NUM
dpc-3965	89	9	months	month	NOUN
dpc-3965	89	10	of	of	ADP
dpc-3965	89	11	injections	injection	NOUN
dpc-3965	89	12	.	.	PUNCT
dpc-3965	90	1	these	these	DET
dpc-3965	90	2	benefits	benefit	NOUN
dpc-3965	90	3	and	and	CCONJ
dpc-3965	90	4	overall	overall	ADJ
dpc-3965	90	5	symptomatic	symptomatic	ADJ
dpc-3965	90	6	improvement	improvement	NOUN
dpc-3965	90	7	were	be	AUX
dpc-3965	90	8	maintained	maintain	VERB
dpc-3965	90	9	for	for	ADP
dpc-3965	90	10	at	at	ADV
dpc-3965	90	11	least	least	ADJ
dpc-3965	90	12	six	six	NUM
dpc-3965	90	13	months	month	NOUN
dpc-3965	90	14	post	post	ADJ
dpc-3965	90	15	-	-	NOUN
dpc-3965	90	16	treatment	treatment	NOUN
dpc-3965	90	17	with	with	ADP
dpc-3965	90	18	no	no	DET
dpc-3965	90	19	occurrence	occurrence	NOUN
dpc-3965	90	20	of	of	ADP
dpc-3965	90	21	serious	serious	ADJ
dpc-3965	90	22	adverse	adverse	ADJ
dpc-3965	90	23	events	event	NOUN
dpc-3965	90	24	[	[	X
dpc-3965	90	25	12	12	NUM
dpc-3965	90	26	]	]	PUNCT
dpc-3965	90	27	.	.	PUNCT
dpc-3965	91	1	cohort	cohort	VERB
dpc-3965	91	2	one	one	NUM
dpc-3965	91	3	survey	survey	NOUN
dpc-3965	91	4	study	study	NOUN
dpc-3965	91	5	on	on	ADP
dpc-3965	91	6	20	20	NUM
dpc-3965	91	7	children	child	NOUN
dpc-3965	91	8	with	with	ADP
dpc-3965	91	9	juvenile	juvenile	ADJ
dpc-3965	91	10	scleroderma	scleroderma	NOUN
dpc-3965	91	11	noted	note	VERB
dpc-3965	91	12	the	the	DET
dpc-3965	91	13	therapeutic	therapeutic	ADJ
dpc-3965	91	14	use	use	NOUN
dpc-3965	91	15	of	of	ADP
dpc-3965	91	16	helium	helium	NOUN
dpc-3965	91	17	-	-	PUNCT
dpc-3965	91	18	neon	neon	NOUN
dpc-3965	91	19	laser	laser	NOUN
dpc-3965	91	20	in	in	ADP
dpc-3965	91	21	combination	combination	NOUN
dpc-3965	91	22	with	with	ADP
dpc-3965	91	23	intramuscular	intramuscular	ADJ
dpc-3965	91	24	or	or	CCONJ
dpc-3965	91	25	electrophoresis	electrophoresis	NOUN
dpc-3965	91	26	hyaluronidase	hyaluronidase	NOUN
dpc-3965	91	27	in	in	ADP
dpc-3965	91	28	areas	area	NOUN
dpc-3965	91	29	of	of	ADP
dpc-3965	91	30	skin	skin	NOUN
dpc-3965	91	31	damage	damage	NOUN
dpc-3965	91	32	in	in	ADP
dpc-3965	91	33	a	a	DET
dpc-3965	91	34	rehabilitation	rehabilitation	NOUN
dpc-3965	91	35	center	center	NOUN
dpc-3965	91	36	.	.	PUNCT
dpc-3965	92	1	however	however	ADV
dpc-3965	92	2	,	,	PUNCT
dpc-3965	92	3	this	this	DET
dpc-3965	92	4	abstract	abstract	NOUN
dpc-3965	92	5	was	be	AUX
dpc-3965	92	6	limited	limit	VERB
dpc-3965	92	7	by	by	ADP
dpc-3965	92	8	its	its	PRON
dpc-3965	92	9	lack	lack	NOUN
dpc-3965	92	10	of	of	ADP
dpc-3965	92	11	detailed	detailed	ADJ
dpc-3965	92	12	administration	administration	NOUN
dpc-3965	92	13	methodology	methodology	NOUN
dpc-3965	92	14	and	and	CCONJ
dpc-3965	92	15	numeric	numeric	ADJ
dpc-3965	92	16	results	result	NOUN
dpc-3965	92	17	[	[	X
dpc-3965	92	18	13	13	NUM
dpc-3965	92	19	]	]	PUNCT
dpc-3965	92	20	.	.	PUNCT
dpc-3965	93	1	review	review	VERB
dpc-3965	93	2	one	one	NUM
dpc-3965	93	3	review	review	NOUN
dpc-3965	93	4	noted	note	VERB
dpc-3965	93	5	the	the	DET
dpc-3965	93	6	use	use	NOUN
dpc-3965	93	7	of	of	ADP
dpc-3965	93	8	iontophoretic	iontophoretic	ADJ
dpc-3965	93	9	hyaluronidase	hyaluronidase	NOUN
dpc-3965	93	10	in	in	ADP
dpc-3965	93	11	ssc	ssc	PROPN
dpc-3965	93	12	.	.	PUNCT
dpc-3965	94	1	iontophoresis	iontophoresis	NOUN
dpc-3965	94	2	is	be	AUX
dpc-3965	94	3	a	a	DET
dpc-3965	94	4	form	form	NOUN
dpc-3965	94	5	of	of	ADP
dpc-3965	94	6	drug	drug	NOUN
dpc-3965	94	7	delivery	delivery	NOUN
dpc-3965	94	8	in	in	ADP
dpc-3965	94	9	which	which	PRON
dpc-3965	94	10	the	the	DET
dpc-3965	94	11	charged	charge	VERB
dpc-3965	94	12	molecule	molecule	NOUN
dpc-3965	94	13	(	(	PUNCT
dpc-3965	94	14	drug	drug	NOUN
dpc-3965	94	15	)	)	PUNCT
dpc-3965	94	16	is	be	AUX
dpc-3965	94	17	delivered	deliver	VERB
dpc-3965	94	18	trans	tran	NOUN
dpc-3965	94	19	-	-	NOUN
dpc-3965	94	20	dermally	dermally	ADV
dpc-3965	94	21	via	via	ADP
dpc-3965	94	22	a	a	DET
dpc-3965	94	23	low	low	ADJ
dpc-3965	94	24	-	-	PUNCT
dpc-3965	94	25	voltage	voltage	NOUN
dpc-3965	94	26	electric	electric	ADJ
dpc-3965	94	27	current	current	NOUN
dpc-3965	95	1	[	[	X
dpc-3965	95	2	14	14	NUM
dpc-3965	95	3	]	]	PUNCT
dpc-3965	95	4	.	.	PUNCT
dpc-3965	96	1	the	the	DET
dpc-3965	96	2	first	first	ADJ
dpc-3965	96	3	review	review	NOUN
dpc-3965	96	4	noted	note	VERB
dpc-3965	96	5	iontophoretic	iontophoretic	ADJ
dpc-3965	96	6	hyaluronidase	hyaluronidase	NOUN
dpc-3965	96	7	was	be	AUX
dpc-3965	96	8	used	use	VERB
dpc-3965	96	9	to	to	PART
dpc-3965	96	10	decrease	decrease	VERB
dpc-3965	96	11	tissue	tissue	NOUN
dpc-3965	96	12	stiffness	stiffness	NOUN
dpc-3965	96	13	and	and	CCONJ
dpc-3965	96	14	cold	cold	ADJ
dpc-3965	96	15	sensitivity	sensitivity	NOUN
dpc-3965	96	16	in	in	ADP
dpc-3965	96	17	ssc	ssc	NOUN
dpc-3965	96	18	patients	patient	NOUN
dpc-3965	96	19	,	,	PUNCT
dpc-3965	96	20	with	with	ADP
dpc-3965	96	21	therapeutic	therapeutic	ADJ
dpc-3965	96	22	benefit	benefit	NOUN
dpc-3965	96	23	lasting	last	VERB
dpc-3965	96	24	around	around	ADP
dpc-3965	96	25	3	3	NUM
dpc-3965	96	26	months	month	NOUN
dpc-3965	96	27	after	after	ADP
dpc-3965	96	28	treatment	treatment	NOUN
dpc-3965	96	29	,	,	PUNCT
dpc-3965	96	30	citing	cite	VERB
dpc-3965	96	31	a	a	DET
dpc-3965	96	32	1951	1951	NUM
dpc-3965	96	33	case	case	NOUN
dpc-3965	96	34	series	series	NOUN
dpc-3965	96	35	by	by	ADP
dpc-3965	96	36	popkin	popkin	NOUN
dpc-3965	97	1	[	[	X
dpc-3965	97	2	14,15	14,15	NUM
dpc-3965	97	3	]	]	PUNCT
dpc-3965	97	4	.	.	PUNCT
dpc-3965	98	1	the	the	DET
dpc-3965	98	2	patient	patient	NOUN
dpc-3965	98	3	was	be	AUX
dpc-3965	98	4	treated	treat	VERB
dpc-3965	98	5	with	with	ADP
dpc-3965	98	6	40	40	NUM
dpc-3965	98	7	applications	application	NOUN
dpc-3965	98	8	of	of	ADP
dpc-3965	98	9	hyaluronidase	hyaluronidase	NOUN
dpc-3965	98	10	over	over	ADP
dpc-3965	98	11	3	3	NUM
dpc-3965	98	12	months	month	NOUN
dpc-3965	98	13	,	,	PUNCT
dpc-3965	98	14	with	with	ADP
dpc-3965	98	15	a	a	DET
dpc-3965	98	16	reduction	reduction	NOUN
dpc-3965	98	17	in	in	ADP
dpc-3965	98	18	sclerodactyly	sclerodactyly	PROPN
dpc-3965	98	19	,	,	PUNCT
dpc-3965	98	20	microstomia	microstomia	NOUN
dpc-3965	98	21	,	,	PUNCT
dpc-3965	98	22	cold	cold	ADJ
dpc-3965	98	23	intolerance	intolerance	NOUN
dpc-3965	98	24	and	and	CCONJ
dpc-3965	98	25	general	general	ADJ
dpc-3965	98	26	cutaneous	cutaneous	ADJ
dpc-3965	98	27	stiffness	stiffness	NOUN
dpc-3965	98	28	throughout	throughout	ADP
dpc-3965	98	29	the	the	DET
dpc-3965	98	30	body	body	NOUN
dpc-3965	98	31	.	.	PUNCT
dpc-3965	99	1	improvement	improvement	NOUN
dpc-3965	99	2	of	of	ADP
dpc-3965	99	3	microstomia	microstomia	NOUN
dpc-3965	99	4	was	be	AUX
dpc-3965	99	5	measured	measure	VERB
dpc-3965	99	6	by	by	ADP
dpc-3965	99	7	increased	increase	VERB
dpc-3965	99	8	teeth	tooth	NOUN
dpc-3965	99	9	opening	opening	NOUN
dpc-3965	99	10	from	from	ADP
dpc-3965	99	11	2.0	2.0	NUM
dpc-3965	99	12	cm	cm	NOUN
dpc-3965	99	13	to	to	ADP
dpc-3965	99	14	2.3	2.3	NUM
dpc-3965	99	15	cm	cm	NOUN
dpc-3965	99	16	,	,	PUNCT
dpc-3965	99	17	whereas	whereas	SCONJ
dpc-3965	99	18	mouth	mouth	NOUN
dpc-3965	99	19	opening	opening	NOUN
dpc-3965	99	20	increased	increase	VERB
dpc-3965	99	21	4	4	NUM
dpc-3965	99	22	review	review	NOUN
dpc-3965	99	23	|	|	ADV
dpc-3965	99	24	dermatol	dermatol	ADJ
dpc-3965	99	25	pract	pract	NOUN
dpc-3965	99	26	concept	concept	NOUN
dpc-3965	99	27	.	.	PUNCT
dpc-3965	100	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	100	2	ta	ta	X
dpc-3965	100	3	b	b	PROPN
dpc-3965	100	4	le	le	ADP
dpc-3965	100	5	1	1	NUM
dpc-3965	100	6	.	.	PUNCT
dpc-3965	101	1	o	o	INTJ
dpc-3965	101	2	ve	ve	VERB
dpc-3965	101	3	rv	rv	X
dpc-3965	101	4	ie	ie	ADV
dpc-3965	101	5	w	w	PROPN
dpc-3965	101	6	o	o	PROPN
dpc-3965	101	7	f	f	X
dpc-3965	101	8	k	k	INTJ
dpc-3965	101	9	ey	ey	INTJ
dpc-3965	101	10	c	c	PROPN
dpc-3965	101	11	as	as	ADP
dpc-3965	101	12	e	e	NOUN
dpc-3965	101	13	r	r	NOUN
dpc-3965	101	14	ep	ep	PROPN
dpc-3965	101	15	or	or	CCONJ
dpc-3965	101	16	t	t	PROPN
dpc-3965	101	17	fi	fi	NOUN
dpc-3965	101	18	nd	nd	INTJ
dpc-3965	101	19	in	in	ADP
dpc-3965	101	20	gs	gs	NOUN
dpc-3965	102	1	o	o	NOUN
dpc-3965	102	2	f	f	NOUN
dpc-3965	103	1	h	h	NOUN
dpc-3965	103	2	ya	ya	NOUN
dpc-3965	103	3	lu	lu	PROPN
dpc-3965	103	4	ro	ro	PROPN
dpc-3965	103	5	ni	ni	PROPN
dpc-3965	103	6	da	da	PROPN
dpc-3965	103	7	se	se	PROPN
dpc-3965	103	8	in	in	ADP
dpc-3965	103	9	m	m	PROPN
dpc-3965	104	1	ic	ic	PROPN
dpc-3965	104	2	ro	ro	PROPN
dpc-3965	104	3	st	st	PROPN
dpc-3965	104	4	om	om	PROPN
dpc-3965	104	5	ia	ia	PROPN
dpc-3965	104	6	st	st	PROPN
dpc-3965	104	7	u	u	PROPN
dpc-3965	104	8	d	d	PROPN
dpc-3965	104	9	y	y	PROPN
dpc-3965	104	10	a	a	DET
dpc-3965	104	11	u	u	X
dpc-3965	104	12	th	th	X
dpc-3965	104	13	o	o	NOUN
dpc-3965	104	14	rs	rs	NOUN
dpc-3965	104	15	pu	pu	PROPN
dpc-3965	104	16	b	b	PROPN
dpc-3965	104	17	lic	lic	PROPN
dpc-3965	104	18	at	at	ADP
dpc-3965	104	19	io	io	PROPN
dpc-3965	104	20	n	n	ADV
dpc-3965	104	21	ye	ye	PROPN
dpc-3965	104	22	ar	ar	PROPN
dpc-3965	104	23	d	d	PROPN
dpc-3965	104	24	ia	ia	PROPN
dpc-3965	104	25	g	g	PROPN
dpc-3965	104	26	n	n	ADV
dpc-3965	104	27	o	o	NOUN
dpc-3965	104	28	si	si	X
dpc-3965	104	29	s	s	PROPN
dpc-3965	104	30	d	d	X
dpc-3965	104	31	el	el	PROPN
dpc-3965	104	32	iv	iv	INTJ
dpc-3965	104	33	er	er	INTJ
dpc-3965	104	34	y	y	INTJ
dpc-3965	104	35	m	m	VERB
dpc-3965	104	36	et	et	NOUN
dpc-3965	104	37	h	h	NOUN
dpc-3965	104	38	o	o	X
dpc-3965	104	39	d	d	X
dpc-3965	104	40	to	to	ADP
dpc-3965	104	41	ta	ta	ADP
dpc-3965	104	42	l	l	NOUN
dpc-3965	104	43	u	u	PROPN
dpc-3965	105	1	n	n	CCONJ
dpc-3965	105	2	it	it	PRON
dpc-3965	105	3	s	s	VERB
dpc-3965	105	4	u	u	X
dpc-3965	105	5	se	se	PROPN
dpc-3965	105	6	d	d	PROPN
dpc-3965	105	7	(	(	PUNCT
dpc-3965	105	8	iu	iu	NOUN
dpc-3965	105	9	)	)	PUNCT
dpc-3965	105	10	u	u	NOUN
dpc-3965	106	1	n	n	ADV
dpc-3965	106	2	it	it	PRON
dpc-3965	106	3	s	s	VERB
dpc-3965	106	4	eq	eq	NOUN
dpc-3965	106	5	u	u	PROPN
dpc-3965	106	6	en	en	X
dpc-3965	106	7	ce	ce	PROPN
dpc-3965	107	1	d	d	PROPN
dpc-3965	107	2	eg	eg	X
dpc-3965	107	3	re	re	ADP
dpc-3965	107	4	e	e	X
dpc-3965	107	5	o	o	X
dpc-3965	107	6	f	f	X
dpc-3965	108	1	i	i	PRON
dpc-3965	108	2	m	m	VERB
dpc-3965	108	3	p	p	VERB
dpc-3965	108	4	ro	ro	INTJ
dpc-3965	108	5	ve	ve	VERB
dpc-3965	108	6	m	m	PROPN
dpc-3965	108	7	en	en	ADP
dpc-3965	108	8	t	t	PROPN
dpc-3965	108	9	(	(	PUNCT
dpc-3965	108	10	%	%	INTJ
dpc-3965	108	11	o	o	X
dpc-3965	108	12	r	r	NOUN
dpc-3965	108	13	m	m	VERB
dpc-3965	108	14	m	m	VERB
dpc-3965	108	15	)	)	PUNCT
dpc-3965	109	1	o	o	NOUN
dpc-3965	109	2	u	u	INTJ
dpc-3965	109	3	tc	tc	X
dpc-3965	109	4	o	o	NOUN
dpc-3965	109	5	m	m	VERB
dpc-3965	109	6	e	e	NOUN
dpc-3965	109	7	m	m	NOUN
dpc-3965	109	8	ea	ea	X
dpc-3965	109	9	su	su	PROPN
dpc-3965	109	10	re	re	VERB
dpc-3965	109	11	m	m	PROPN
dpc-3965	109	12	en	en	ADP
dpc-3965	109	13	t	t	X
dpc-3965	109	14	ti	ti	PROPN
dpc-3965	109	15	m	m	PROPN
dpc-3965	109	16	e	e	NOUN
dpc-3965	109	17	to	to	PART
dpc-3965	109	18	se	se	PROPN
dpc-3965	109	19	co	co	PROPN
dpc-3965	109	20	n	n	PROPN
dpc-3965	109	21	d	d	PROPN
dpc-3965	109	22	ar	ar	PROPN
dpc-3965	109	23	y	y	PROPN
dpc-3965	109	24	in	in	ADP
dpc-3965	109	25	je	je	PROPN
dpc-3965	109	26	ct	ct	PROPN
dpc-3965	109	27	io	io	PROPN
dpc-3965	109	28	n	n	PROPN
dpc-3965	109	29	a	a	PRON
dpc-3965	109	30	d	d	X
dpc-3965	109	31	ve	ve	VERB
dpc-3965	109	32	rs	rs	NOUN
dpc-3965	109	33	e	e	NOUN
dpc-3965	109	34	si	si	PROPN
dpc-3965	109	35	d	d	PROPN
dpc-3965	109	36	e	e	X
dpc-3965	109	37	ef	ef	X
dpc-3965	109	38	fe	fe	X
dpc-3965	109	39	ct	ct	PROPN
dpc-3965	109	40	s	s	PROPN
dpc-3965	109	41	a	a	DET
dpc-3965	109	42	bb	bb	NOUN
dpc-3965	109	43	as	as	ADP
dpc-3965	109	44	e	e	PROPN
dpc-3965	109	45	t	t	PROPN
dpc-3965	109	46	al	al	PROPN
dpc-3965	109	47	[	[	PUNCT
dpc-3965	109	48	8	8	NUM
dpc-3965	109	49	]	]	SYM
dpc-3965	109	50	20	20	NUM
dpc-3965	109	51	19	19	NUM
dpc-3965	109	52	pa	pa	PROPN
dpc-3965	109	53	ns	ns	NUM
dpc-3965	109	54	cl	cl	NOUN
dpc-3965	109	55	er	er	INTJ
dpc-3965	109	56	ot	ot	INTJ
dpc-3965	109	57	ic	ic	PROPN
dpc-3965	109	58	m	m	PROPN
dpc-3965	109	59	or	or	CCONJ
dpc-3965	109	60	ph	ph	ADJ
dpc-3965	109	61	ea	ea	NOUN
dpc-3965	109	62	in	in	ADP
dpc-3965	109	63	tr	tr	NOUN
dpc-3965	109	64	ad	ad	NOUN
dpc-3965	109	65	er	er	INTJ
dpc-3965	109	66	m	m	NOUN
dpc-3965	109	67	al	al	PROPN
dpc-3965	109	68	in	in	ADP
dpc-3965	109	69	je	je	PROPN
dpc-3965	109	70	ct	ct	PROPN
dpc-3965	109	71	io	io	PROPN
dpc-3965	109	72	n	n	PROPN
dpc-3965	109	73	43	43	NUM
dpc-3965	109	74	5	5	NUM
dpc-3965	109	75	iu	iu	ADP
dpc-3965	109	76	r	r	NOUN
dpc-3965	109	77	ig	ig	PROPN
dpc-3965	110	1	ht	ht	INTJ
dpc-3965	110	2	ja	ja	PROPN
dpc-3965	110	3	w	w	PROPN
dpc-3965	110	4	lin	lin	PROPN
dpc-3965	110	5	e	e	PROPN
dpc-3965	110	6	:	:	PUNCT
dpc-3965	110	7	•	•	NUM
dpc-3965	110	8	80	80	NUM
dpc-3965	111	1	i	i	PRON
dpc-3965	111	2	u	u	NOUN
dpc-3965	111	3	x	x	PROPN
dpc-3965	111	4	2	2	NUM
dpc-3965	111	5	50	50	NUM
dpc-3965	111	6	i	i	NOUN
dpc-3965	111	7	u	u	VERB
dpc-3965	111	8	l	l	NOUN
dpc-3965	111	9	ef	ef	NOUN
dpc-3965	111	10	t	t	PROPN
dpc-3965	111	11	ja	ja	PROPN
dpc-3965	111	12	w	w	PROPN
dpc-3965	111	13	lin	lin	PROPN
dpc-3965	112	1	e	e	PROPN
dpc-3965	112	2	:	:	PUNCT
dpc-3965	112	3	•	•	NUM
dpc-3965	112	4	35	35	NUM
dpc-3965	112	5	i	i	NOUN
dpc-3965	112	6	u	u	NOUN
dpc-3965	112	7	x	x	PROPN
dpc-3965	112	8	2	2	NUM
dpc-3965	112	9	•	•	NUM
dpc-3965	112	10	50	50	NUM
dpc-3965	112	11	i	i	NOUN
dpc-3965	112	12	u	u	VERB
dpc-3965	112	13	•	•	NOUN
dpc-3965	112	14	15	15	NUM
dpc-3965	113	1	i	i	PRON
dpc-3965	113	2	u	u	VERB
dpc-3965	113	3	c	c	VERB
dpc-3965	113	4	hi	hi	INTJ
dpc-3965	113	5	n	n	CCONJ
dpc-3965	113	6	:	:	PUNCT
dpc-3965	113	7	•	•	NUM
dpc-3965	113	8	35	35	NUM
dpc-3965	113	9	i	i	NOUN
dpc-3965	113	10	u	u	NOUN
dpc-3965	113	11	x	x	PROPN
dpc-3965	113	12	2	2	NUM
dpc-3965	113	13	•	•	NUM
dpc-3965	113	14	20	20	NUM
dpc-3965	114	1	i	i	NOUN
dpc-3965	114	2	u	u	X
dpc-3965	114	3	+3	+3	PROPN
dpc-3965	114	4	0	0	NUM
dpc-3965	114	5	m	m	VERB
dpc-3965	114	6	m	m	VERB
dpc-3965	114	7	+3	+3	ADJ
dpc-3965	114	8	0	0	PUNCT
dpc-3965	114	9	m	m	VERB
dpc-3965	114	10	m	m	VERB
dpc-3965	114	11	2	2	NUM
dpc-3965	114	12	w	w	PROPN
dpc-3965	114	13	ee	ee	PROPN
dpc-3965	114	14	ks	ks	PROPN
dpc-3965	114	15	m	m	PROPN
dpc-3965	114	16	ild	ild	PROPN
dpc-3965	114	17	di	di	X
dpc-3965	114	18	sc	sc	PROPN
dpc-3965	114	19	om	om	PROPN
dpc-3965	115	1	fo	fo	INTJ
dpc-3965	115	2	rt	rt	PROPN
dpc-3965	115	3	a	a	DET
dpc-3965	115	4	t	t	NOUN
dpc-3965	115	5	in	in	ADP
dpc-3965	115	6	je	je	PROPN
dpc-3965	115	7	ct	ct	PROPN
dpc-3965	115	8	io	io	PROPN
dpc-3965	115	9	n	n	ADV
dpc-3965	115	10	si	si	INTJ
dpc-3965	115	11	te	te	PROPN
dpc-3965	115	12	c	c	PROPN
dpc-3965	115	13	ho	ho	PROPN
dpc-3965	115	14	pr	pr	VERB
dpc-3965	115	15	a	a	DET
dpc-3965	115	16	et	et	NOUN
dpc-3965	115	17	a	a	DET
dpc-3965	115	18	l	l	NOUN
dpc-3965	115	19	[	[	PUNCT
dpc-3965	115	20	9	9	NUM
dpc-3965	115	21	]	]	SYM
dpc-3965	115	22	20	20	NUM
dpc-3965	115	23	22	22	NUM
dpc-3965	115	24	d	d	NOUN
dpc-3965	115	25	if	if	SCONJ
dpc-3965	115	26	fu	fu	PROPN
dpc-3965	115	27	se	se	PROPN
dpc-3965	115	28	s	s	VERB
dpc-3965	116	1	ys	ys	INTJ
dpc-3965	116	2	te	te	PROPN
dpc-3965	116	3	m	m	PROPN
dpc-3965	116	4	ic	ic	PROPN
dpc-3965	116	5	sc	sc	PROPN
dpc-3965	116	6	le	le	X
dpc-3965	116	7	ro	ro	PROPN
dpc-3965	116	8	de	de	PROPN
dpc-3965	116	9	rm	rm	PROPN
dpc-3965	116	10	a	a	PRON
dpc-3965	116	11	in	in	ADP
dpc-3965	116	12	tr	tr	NOUN
dpc-3965	116	13	ad	ad	NOUN
dpc-3965	117	1	er	er	INTJ
dpc-3965	117	2	m	m	NOUN
dpc-3965	117	3	al	al	PROPN
dpc-3965	117	4	in	in	ADP
dpc-3965	117	5	je	je	PROPN
dpc-3965	117	6	ct	ct	PROPN
dpc-3965	117	7	io	io	PROPN
dpc-3965	118	1	n	n	PROPN
dpc-3965	118	2	30	30	NUM
dpc-3965	118	3	0	0	NUM
dpc-3965	118	4	iu	iu	ADP
dpc-3965	118	5	15	15	NUM
dpc-3965	118	6	0	0	NUM
dpc-3965	118	7	iu	iu	ADP
dpc-3965	118	8	x	x	SYM
dpc-3965	118	9	2	2	NUM
dpc-3965	118	10	+	+	NUM
dpc-3965	118	11	15	15	NUM
dpc-3965	118	12	m	m	NOUN
dpc-3965	118	13	m	m	VERB
dpc-3965	118	14	o	o	NOUN
dpc-3965	118	15	ra	ra	NOUN
dpc-3965	118	16	l	l	NOUN
dpc-3965	119	1	a	a	X
dpc-3965	120	1	pe	pe	INTJ
dpc-3965	120	2	rt	rt	INTJ
dpc-3965	120	3	ur	ur	INTJ
dpc-3965	120	4	e	e	PROPN
dpc-3965	120	5	ci	ci	PROPN
dpc-3965	120	6	rc	rc	PROPN
dpc-3965	120	7	um	um	INTJ
dpc-3965	120	8	fe	fe	X
dpc-3965	120	9	re	re	X
dpc-3965	120	10	nc	nc	PROPN
dpc-3965	120	11	e	e	PROPN
dpc-3965	120	12	6	6	NUM
dpc-3965	120	13	m	m	NOUN
dpc-3965	120	14	on	on	ADP
dpc-3965	120	15	th	th	NUM
dpc-3965	120	16	s	s	NOUN
dpc-3965	120	17	n	n	X
dpc-3965	120	18	on	on	ADP
dpc-3965	120	19	e	e	X
dpc-3965	120	20	re	re	X
dpc-3965	120	21	po	po	PROPN
dpc-3965	121	1	rt	rt	PROPN
dpc-3965	121	2	ed	ed	PROPN
dpc-3965	121	3	k	k	PROPN
dpc-3965	121	4	um	um	INTJ
dpc-3965	122	1	ar	ar	PROPN
dpc-3965	122	2	e	e	PROPN
dpc-3965	122	3	t	t	PROPN
dpc-3965	122	4	al	al	PROPN
dpc-3965	123	1	[	[	X
dpc-3965	123	2	1	1	NUM
dpc-3965	123	3	0	0	NUM
dpc-3965	123	4	]	]	SYM
dpc-3965	123	5	20	20	NUM
dpc-3965	123	6	16	16	NUM
dpc-3965	123	7	l	l	NOUN
dpc-3965	124	1	i	i	PRON
dpc-3965	124	2	m	m	VERB
dpc-3965	124	3	it	it	PRON
dpc-3965	124	4	ed	ed	NOUN
dpc-3965	124	5	s	s	X
dpc-3965	124	6	ys	ys	NOUN
dpc-3965	124	7	te	te	PROPN
dpc-3965	124	8	m	m	PROPN
dpc-3965	124	9	ic	ic	PROPN
dpc-3965	124	10	sc	sc	PROPN
dpc-3965	124	11	le	le	X
dpc-3965	124	12	ro	ro	PROPN
dpc-3965	124	13	de	de	PROPN
dpc-3965	124	14	rm	rm	PROPN
dpc-3965	124	15	a	a	PRON
dpc-3965	124	16	in	in	ADP
dpc-3965	124	17	tr	tr	NOUN
dpc-3965	124	18	ad	ad	NOUN
dpc-3965	125	1	er	er	INTJ
dpc-3965	125	2	m	m	NOUN
dpc-3965	125	3	al	al	PROPN
dpc-3965	125	4	in	in	ADP
dpc-3965	125	5	je	je	PROPN
dpc-3965	125	6	ct	ct	PROPN
dpc-3965	125	7	io	io	PROPN
dpc-3965	125	8	n	n	PROPN
dpc-3965	125	9	15	15	NUM
dpc-3965	125	10	00	00	NUM
dpc-3965	126	1	i	i	PRON
dpc-3965	126	2	u	u	VERB
dpc-3965	126	3	u	u	NOUN
dpc-3965	126	4	nk	nk	INTJ
dpc-3965	126	5	no	no	INTJ
dpc-3965	126	6	w	w	PROPN
dpc-3965	126	7	n	n	ADV
dpc-3965	126	8	+1	+1	NOUN
dpc-3965	126	9	3	3	NUM
dpc-3965	126	10	m	m	NOUN
dpc-3965	126	11	m	m	VERB
dpc-3965	126	12	o	o	NOUN
dpc-3965	126	13	ra	ra	INTJ
dpc-3965	127	1	l	l	NOUN
dpc-3965	127	2	ap	ap	PROPN
dpc-3965	128	1	er	er	INTJ
dpc-3965	128	2	tu	tu	PROPN
dpc-3965	128	3	re	re	PROPN
dpc-3965	128	4	v	v	X
dpc-3965	128	5	er	er	INTJ
dpc-3965	128	6	ti	ti	NOUN
dpc-3965	128	7	ca	ca	NOUN
dpc-3965	128	8	l	l	PROPN
dpc-3965	128	9	2	2	NUM
dpc-3965	128	10	w	w	PROPN
dpc-3965	128	11	ee	ee	PROPN
dpc-3965	128	12	ks	ks	PROPN
dpc-3965	128	13	g	g	PROPN
dpc-3965	128	14	as	as	SCONJ
dpc-3965	128	15	tr	tr	NOUN
dpc-3965	128	16	it	it	PRON
dpc-3965	128	17	is	be	AUX
dpc-3965	128	18	se	se	PROPN
dpc-3965	128	19	co	co	X
dpc-3965	128	20	nd	nd	PROPN
dpc-3965	128	21	ar	ar	PROPN
dpc-3965	128	22	y	y	PROPN
dpc-3965	128	23	to	to	ADP
dpc-3965	128	24	de	de	PROPN
dpc-3965	128	25	xa	xa	PROPN
dpc-3965	128	26	m	m	PROPN
dpc-3965	128	27	et	et	NOUN
dpc-3965	129	1	ha	ha	INTJ
dpc-3965	129	2	so	so	ADV
dpc-3965	129	3	ne	ne	PROPN
dpc-3965	129	4	so	so	ADV
dpc-3965	129	5	di	di	X
dpc-3965	129	6	um	um	INTJ
dpc-3965	129	7	ph	ph	PROPN
dpc-3965	129	8	os	os	NOUN
dpc-3965	129	9	ph	ph	NOUN
dpc-3965	129	10	at	at	ADP
dpc-3965	129	11	e	e	PROPN
dpc-3965	129	12	co	co	X
dpc-3965	129	13	ad	ad	PROPN
dpc-3965	129	14	m	m	VERB
dpc-3965	129	15	in	in	ADP
dpc-3965	129	16	is	be	AUX
dpc-3965	129	17	tr	tr	VERB
dpc-3965	129	18	at	at	ADP
dpc-3965	129	19	io	io	PROPN
dpc-3965	129	20	n	n	PRON
dpc-3965	129	21	m	m	PROPN
dpc-3965	129	22	el	el	PROPN
dpc-3965	129	23	vi	vi	PROPN
dpc-3965	130	1	n	n	ADP
dpc-3965	130	2	et	et	NOUN
dpc-3965	130	3	a	a	DET
dpc-3965	130	4	l	l	NOUN
dpc-3965	131	1	[	[	X
dpc-3965	131	2	1	1	NUM
dpc-3965	131	3	1	1	NUM
dpc-3965	131	4	]	]	SYM
dpc-3965	131	5	20	20	NUM
dpc-3965	131	6	19	19	NUM
dpc-3965	131	7	l	l	NOUN
dpc-3965	132	1	i	i	PRON
dpc-3965	132	2	m	m	VERB
dpc-3965	132	3	it	it	PRON
dpc-3965	132	4	ed	ed	NOUN
dpc-3965	132	5	s	s	X
dpc-3965	132	6	ys	ys	NOUN
dpc-3965	132	7	te	te	PROPN
dpc-3965	132	8	m	m	PROPN
dpc-3965	132	9	ic	ic	PROPN
dpc-3965	132	10	sc	sc	PROPN
dpc-3965	132	11	le	le	X
dpc-3965	132	12	ro	ro	PROPN
dpc-3965	132	13	de	de	PROPN
dpc-3965	132	14	rm	rm	PROPN
dpc-3965	132	15	a	a	PRON
dpc-3965	132	16	in	in	ADP
dpc-3965	132	17	tr	tr	NOUN
dpc-3965	132	18	ad	ad	NOUN
dpc-3965	133	1	er	er	INTJ
dpc-3965	133	2	m	m	NOUN
dpc-3965	133	3	al	al	PROPN
dpc-3965	133	4	in	in	ADP
dpc-3965	133	5	je	je	PROPN
dpc-3965	133	6	ct	ct	PROPN
dpc-3965	133	7	io	io	PROPN
dpc-3965	134	1	n	n	PROPN
dpc-3965	134	2	47	47	NUM
dpc-3965	134	3	0	0	NUM
dpc-3965	134	4	iu	iu	ADP
dpc-3965	134	5	20	20	NUM
dpc-3965	134	6	i	i	NOUN
dpc-3965	134	7	u	u	NOUN
dpc-3965	134	8	,	,	PUNCT
dpc-3965	134	9	5	5	NUM
dpc-3965	134	10	0	0	NUM
dpc-3965	134	11	iu	iu	ADP
dpc-3965	134	12	,	,	PUNCT
dpc-3965	134	13	2	2	NUM
dpc-3965	134	14	00	00	NUM
dpc-3965	135	1	i	i	PRON
dpc-3965	135	2	u	u	VERB
dpc-3965	136	1	x2	x2	NOUN
dpc-3965	136	2	+1	+1	ADJ
dpc-3965	136	3	1	1	NUM
dpc-3965	136	4	%	%	NOUN
dpc-3965	136	5	m	m	NOUN
dpc-3965	136	6	h	h	NOUN
dpc-3965	136	7	is	be	AUX
dpc-3965	136	8	s	s	PROPN
dpc-3965	136	9	2	2	NUM
dpc-3965	136	10	m	m	NOUN
dpc-3965	136	11	on	on	ADP
dpc-3965	136	12	th	th	NUM
dpc-3965	136	13	s	s	NOUN
dpc-3965	136	14	m	m	NOUN
dpc-3965	136	15	ild	ild	PROPN
dpc-3965	136	16	b	b	PROPN
dpc-3965	136	17	ru	ru	NOUN
dpc-3965	136	18	is	be	AUX
dpc-3965	136	19	in	in	ADP
dpc-3965	136	20	g	g	PROPN
dpc-3965	136	21	at	at	ADP
dpc-3965	136	22	in	in	ADP
dpc-3965	136	23	je	je	PROPN
dpc-3965	136	24	ct	ct	PROPN
dpc-3965	136	25	io	io	PROPN
dpc-3965	136	26	n	n	PROPN
dpc-3965	136	27	si	si	INTJ
dpc-3965	137	1	te	te	ADP
dpc-3965	137	2	m	m	VERB
dpc-3965	137	3	in	in	ADP
dpc-3965	137	4	e	e	PROPN
dpc-3965	137	5	t	t	PROPN
dpc-3965	137	6	al	al	PROPN
dpc-3965	137	7	[	[	PUNCT
dpc-3965	137	8	12	12	NUM
dpc-3965	137	9	]	]	SYM
dpc-3965	137	10	20	20	NUM
dpc-3965	137	11	23	23	NUM
dpc-3965	137	12	l	l	NOUN
dpc-3965	138	1	i	i	PRON
dpc-3965	138	2	m	m	VERB
dpc-3965	138	3	it	it	PRON
dpc-3965	138	4	ed	ed	NOUN
dpc-3965	138	5	s	s	X
dpc-3965	138	6	ys	ys	NOUN
dpc-3965	138	7	te	te	PROPN
dpc-3965	138	8	m	m	PROPN
dpc-3965	138	9	ic	ic	PROPN
dpc-3965	138	10	sc	sc	PROPN
dpc-3965	138	11	le	le	X
dpc-3965	138	12	ro	ro	PROPN
dpc-3965	138	13	de	de	PROPN
dpc-3965	138	14	rm	rm	PROPN
dpc-3965	138	15	a	a	PROPN
dpc-3965	138	16	(	(	PUNCT
dpc-3965	138	17	n	n	NOUN
dpc-3965	138	18	=	=	NOUN
dpc-3965	138	19	2	2	NUM
dpc-3965	138	20	)	)	PUNCT
dpc-3965	138	21	,	,	PUNCT
dpc-3965	138	22	di	di	INTJ
dpc-3965	138	23	ff	ff	VERB
dpc-3965	138	24	us	we	PRON
dpc-3965	139	1	e	e	PROPN
dpc-3965	139	2	sy	sy	PROPN
dpc-3965	139	3	st	st	PROPN
dpc-3965	139	4	em	em	PRON
dpc-3965	139	5	ic	ic	PROPN
dpc-3965	139	6	sc	sc	PROPN
dpc-3965	139	7	le	le	X
dpc-3965	139	8	ro	ro	PROPN
dpc-3965	139	9	de	de	PROPN
dpc-3965	139	10	rm	rm	PROPN
dpc-3965	139	11	a	a	PROPN
dpc-3965	139	12	(	(	PUNCT
dpc-3965	139	13	n	n	NOUN
dpc-3965	139	14	=	=	NOUN
dpc-3965	139	15	1	1	NUM
dpc-3965	139	16	)	)	PUNCT
dpc-3965	139	17	in	in	ADP
dpc-3965	139	18	tr	tr	NOUN
dpc-3965	139	19	ad	ad	NOUN
dpc-3965	139	20	er	er	INTJ
dpc-3965	139	21	m	m	NOUN
dpc-3965	139	22	al	al	PROPN
dpc-3965	139	23	in	in	ADP
dpc-3965	139	24	je	je	PROPN
dpc-3965	139	25	ct	ct	PROPN
dpc-3965	139	26	io	io	PROPN
dpc-3965	139	27	n	n	PROPN
dpc-3965	139	28	20	20	NUM
dpc-3965	139	29	0	0	NUM
dpc-3965	139	30	iu	iu	ADP
dpc-3965	139	31	20	20	NUM
dpc-3965	139	32	0	0	NUM
dpc-3965	139	33	iu	iu	ADP
dpc-3965	139	34	x	x	SYM
dpc-3965	139	35	2	2	NUM
dpc-3965	139	36	-7	-7	NOUN
dpc-3965	139	37	,	,	PUNCT
dpc-3965	139	38	de	de	X
dpc-3965	139	39	pe	pe	X
dpc-3965	139	40	nd	nd	INTJ
dpc-3965	139	41	in	in	ADP
dpc-3965	139	42	g	g	NOUN
dpc-3965	139	43	on	on	ADP
dpc-3965	139	44	p	p	NOUN
dpc-3965	139	45	at	at	ADP
dpc-3965	139	46	ie	ie	ADV
dpc-3965	139	47	nt	not	PART
dpc-3965	139	48	o	o	PROPN
dpc-3965	140	1	n	n	CCONJ
dpc-3965	140	2	av	av	PROPN
dpc-3965	140	3	er	er	INTJ
dpc-3965	140	4	ag	ag	PROPN
dpc-3965	140	5	e	e	PROPN
dpc-3965	140	6	ov	ov	PROPN
dpc-3965	140	7	er	er	INTJ
dpc-3965	140	8	4	4	NUM
dpc-3965	140	9	pa	pa	PROPN
dpc-3965	140	10	ti	ti	PROPN
dpc-3965	140	11	en	en	X
dpc-3965	140	12	ts	ts	X
dpc-3965	140	13	:	:	PUNCT
dpc-3965	140	14	m	m	VERB
dpc-3965	140	15	o	o	NOUN
dpc-3965	140	16	c	c	NOUN
dpc-3965	140	17	:	:	PUNCT
dpc-3965	141	1	+9	+9	PROPN
dpc-3965	141	2	m	m	NOUN
dpc-3965	141	3	m	m	VERB
dpc-3965	141	4	m	m	VERB
dpc-3965	141	5	h	h	NOUN
dpc-3965	141	6	is	be	AUX
dpc-3965	141	7	s	s	NOUN
dpc-3965	141	8	:	:	PUNCT
dpc-3965	141	9	+6	+6	PROPN
dpc-3965	141	10	1	1	NUM
dpc-3965	141	11	.	.	SYM
dpc-3965	141	12	9	9	NUM
dpc-3965	141	13	%	%	NOUN
dpc-3965	141	14	m	m	NOUN
dpc-3965	141	15	o	o	NOUN
dpc-3965	141	16	c	c	NOUN
dpc-3965	141	17	,	,	PUNCT
dpc-3965	141	18	m	m	VERB
dpc-3965	141	19	h	h	NOUN
dpc-3965	141	20	is	be	AUX
dpc-3965	141	21	s	s	PROPN
dpc-3965	141	22	1	1	NUM
dpc-3965	141	23	m	m	NOUN
dpc-3965	141	24	on	on	ADP
dpc-3965	141	25	th	th	INTJ
dpc-3965	141	26	t	t	NOUN
dpc-3965	141	27	ra	ra	PROPN
dpc-3965	142	1	ns	ns	INTJ
dpc-3965	142	2	ie	ie	PROPN
dpc-3965	142	3	nt	not	PART
dpc-3965	142	4	br	br	PROPN
dpc-3965	142	5	ui	ui	INTJ
dpc-3965	142	6	si	si	PROPN
dpc-3965	142	7	ng	ng	PROPN
dpc-3965	142	8	an	an	PROPN
dpc-3965	142	9	d	d	X
dpc-3965	142	10	pa	pa	PROPN
dpc-3965	142	11	in	in	ADP
dpc-3965	142	12	a	a	DET
dpc-3965	142	13	t	t	NOUN
dpc-3965	142	14	in	in	ADP
dpc-3965	142	15	je	je	PROPN
dpc-3965	142	16	ct	ct	PROPN
dpc-3965	142	17	io	io	PROPN
dpc-3965	142	18	n	n	PROPN
dpc-3965	142	19	si	si	X
dpc-3965	142	20	te	te	X
dpc-3965	142	21	po	po	X
dpc-3965	142	22	pk	pk	PROPN
dpc-3965	142	23	in	in	ADP
dpc-3965	142	24	(	(	PUNCT
dpc-3965	142	25	p	p	X
dpc-3965	142	26	at	at	ADP
dpc-3965	142	27	ie	ie	X
dpc-3965	142	28	nt	not	PART
dpc-3965	142	29	1	1	NUM
dpc-3965	142	30	)	)	PUNCT
dpc-3965	142	31	19	19	NUM
dpc-3965	142	32	51	51	NUM
dpc-3965	142	33	g	g	NOUN
dpc-3965	142	34	en	en	INTJ
dpc-3965	142	35	er	er	INTJ
dpc-3965	142	36	al	al	PROPN
dpc-3965	142	37	iz	iz	INTJ
dpc-3965	142	38	ed	ed	PROPN
dpc-3965	142	39	sc	sc	PROPN
dpc-3965	142	40	le	le	X
dpc-3965	142	41	ro	ro	PROPN
dpc-3965	142	42	de	de	PROPN
dpc-3965	142	43	rm	rm	PROPN
dpc-3965	142	44	a	a	PROPN
dpc-3965	142	45	io	io	X
dpc-3965	142	46	nt	not	PART
dpc-3965	142	47	op	op	NOUN
dpc-3965	142	48	ho	ho	PROPN
dpc-3965	142	49	re	re	ADP
dpc-3965	142	50	si	si	PROPN
dpc-3965	142	51	s	s	PROPN
dpc-3965	142	52	31	31	NUM
dpc-3965	142	53	1	1	NUM
dpc-3965	142	54	iu	iu	ADP
dpc-3965	142	55	0	0	NUM
dpc-3965	142	56	.	.	NOUN
dpc-3965	142	57	1	1	NUM
dpc-3965	142	58	iu	iu	ADV
dpc-3965	142	59	,	,	PUNCT
dpc-3965	142	60	1	1	NUM
dpc-3965	142	61	i	i	PRON
dpc-3965	142	62	u	u	NOUN
dpc-3965	142	63	,	,	PUNCT
dpc-3965	142	64	1	1	NUM
dpc-3965	142	65	0	0	NUM
dpc-3965	142	66	iu	iu	ADP
dpc-3965	142	67	,	,	PUNCT
dpc-3965	142	68	2	2	NUM
dpc-3965	142	69	0	0	NUM
dpc-3965	142	70	iu	iu	ADP
dpc-3965	142	71	x	x	SYM
dpc-3965	142	72	1	1	NUM
dpc-3965	142	73	5	5	NUM
dpc-3965	142	74	+3	+3	PROPN
dpc-3965	142	75	m	m	VERB
dpc-3965	142	76	m	m	VERB
dpc-3965	142	77	;	;	PUNCT
dpc-3965	142	78	+	+	NUM
dpc-3965	142	79	15	15	NUM
dpc-3965	142	80	m	m	NOUN
dpc-3965	142	81	m	m	VERB
dpc-3965	142	82	o	o	NOUN
dpc-3965	142	83	ra	ra	NOUN
dpc-3965	142	84	l	l	NOUN
dpc-3965	142	85	a	a	X
dpc-3965	143	1	pe	pe	INTJ
dpc-3965	143	2	rt	rt	INTJ
dpc-3965	143	3	ur	ur	INTJ
dpc-3965	143	4	e	e	PROPN
dpc-3965	143	5	in	in	ADP
dpc-3965	143	6	te	te	PROPN
dpc-3965	143	7	ri	ri	PROPN
dpc-3965	143	8	nc	nc	PROPN
dpc-3965	143	9	is	be	AUX
dpc-3965	143	10	io	io	X
dpc-3965	143	11	na	na	X
dpc-3965	143	12	l	l	NOUN
dpc-3965	143	13	;	;	PUNCT
dpc-3965	143	14	or	or	CCONJ
dpc-3965	143	15	al	al	PROPN
dpc-3965	143	16	a	a	X
dpc-3965	144	1	pe	pe	INTJ
dpc-3965	144	2	rt	rt	INTJ
dpc-3965	144	3	ur	ur	INTJ
dpc-3965	145	1	e	e	PROPN
dpc-3965	145	2	lip	lip	NOUN
dpc-3965	145	3	s	s	PART
dpc-3965	145	4	2	2	NUM
dpc-3965	145	5	w	w	PROPN
dpc-3965	145	6	ee	ee	PROPN
dpc-3965	145	7	ks	ks	PROPN
dpc-3965	145	8	n	n	PROPN
dpc-3965	145	9	on	on	ADP
dpc-3965	145	10	e	e	X
dpc-3965	145	11	re	re	X
dpc-3965	145	12	po	po	PROPN
dpc-3965	146	1	rt	rt	PROPN
dpc-3965	146	2	ed	ed	PROPN
dpc-3965	146	3	po	po	PROPN
dpc-3965	146	4	pk	pk	PROPN
dpc-3965	146	5	in	in	ADP
dpc-3965	146	6	(	(	PUNCT
dpc-3965	146	7	p	p	X
dpc-3965	146	8	at	at	ADP
dpc-3965	146	9	ie	ie	X
dpc-3965	146	10	nt	not	PART
dpc-3965	146	11	2	2	NUM
dpc-3965	146	12	)	)	PUNCT
dpc-3965	146	13	19	19	NUM
dpc-3965	146	14	51	51	NUM
dpc-3965	146	15	se	se	X
dpc-3965	146	16	ve	ve	AUX
dpc-3965	146	17	re	re	VERB
dpc-3965	146	18	g	g	PROPN
dpc-3965	146	19	en	en	PROPN
dpc-3965	146	20	er	er	INTJ
dpc-3965	146	21	al	al	PROPN
dpc-3965	146	22	iz	iz	INTJ
dpc-3965	146	23	ed	ed	PROPN
dpc-3965	146	24	sc	sc	PROPN
dpc-3965	146	25	le	le	X
dpc-3965	146	26	ro	ro	PROPN
dpc-3965	146	27	de	de	PROPN
dpc-3965	146	28	rm	rm	PROPN
dpc-3965	146	29	a	a	PROPN
dpc-3965	146	30	io	io	X
dpc-3965	146	31	nt	not	PART
dpc-3965	146	32	op	op	NOUN
dpc-3965	146	33	ho	ho	PROPN
dpc-3965	146	34	re	re	ADP
dpc-3965	146	35	si	si	PROPN
dpc-3965	146	36	s	s	PROPN
dpc-3965	146	37	61	61	NUM
dpc-3965	146	38	1	1	NUM
dpc-3965	146	39	iu	iu	ADP
dpc-3965	146	40	0	0	NUM
dpc-3965	146	41	.	.	NOUN
dpc-3965	146	42	1	1	NUM
dpc-3965	146	43	iu	iu	ADV
dpc-3965	146	44	,	,	PUNCT
dpc-3965	146	45	1	1	NUM
dpc-3965	146	46	i	i	PRON
dpc-3965	146	47	u	u	NOUN
dpc-3965	146	48	,	,	PUNCT
dpc-3965	146	49	1	1	NUM
dpc-3965	146	50	0	0	NUM
dpc-3965	146	51	iu	iu	ADP
dpc-3965	146	52	,	,	PUNCT
dpc-3965	146	53	2	2	NUM
dpc-3965	146	54	0	0	NUM
dpc-3965	146	55	iu	iu	ADP
dpc-3965	146	56	x	x	SYM
dpc-3965	146	57	3	3	NUM
dpc-3965	146	58	0	0	NUM
dpc-3965	146	59	n	n	NOUN
dpc-3965	146	60	/a	/a	PUNCT
dpc-3965	146	61	n	n	CCONJ
dpc-3965	146	62	/a	/a	SYM
dpc-3965	146	63	2	2	NUM
dpc-3965	146	64	w	w	PROPN
dpc-3965	146	65	ee	ee	PROPN
dpc-3965	146	66	ks	ks	PROPN
dpc-3965	146	67	n	n	PROPN
dpc-3965	146	68	on	on	ADP
dpc-3965	146	69	e	e	X
dpc-3965	146	70	re	re	X
dpc-3965	146	71	po	po	PROPN
dpc-3965	147	1	rt	rt	PROPN
dpc-3965	147	2	ed	ed	PROPN
dpc-3965	147	3	m	m	PROPN
dpc-3965	147	4	h	h	NOUN
dpc-3965	147	5	is	be	AUX
dpc-3965	147	6	s	s	PART
dpc-3965	147	7	=	=	NOUN
dpc-3965	147	8	m	m	VERB
dpc-3965	147	9	ou	ou	ADP
dpc-3965	147	10	th	th	NUM
dpc-3965	147	11	h	h	NOUN
dpc-3965	148	1	an	an	DET
dpc-3965	148	2	di	di	NOUN
dpc-3965	148	3	ca	ca	NOUN
dpc-3965	148	4	p	p	NOUN
dpc-3965	148	5	in	in	ADP
dpc-3965	148	6	s	s	PRON
dpc-3965	148	7	ys	ys	NOUN
dpc-3965	148	8	te	te	PROPN
dpc-3965	148	9	m	m	PROPN
dpc-3965	148	10	ic	ic	PROPN
dpc-3965	148	11	s	s	VERB
dpc-3965	148	12	cl	cl	NOUN
dpc-3965	149	1	er	er	INTJ
dpc-3965	149	2	os	os	NOUN
dpc-3965	149	3	is	be	AUX
dpc-3965	149	4	;	;	PUNCT
dpc-3965	149	5	m	m	VERB
dpc-3965	149	6	o	o	NOUN
dpc-3965	149	7	c	c	NOUN
dpc-3965	150	1	=	=	SYM
dpc-3965	150	2	m	m	VERB
dpc-3965	150	3	ou	ou	X
dpc-3965	150	4	th	th	X
dpc-3965	150	5	o	o	X
dpc-3965	150	6	pe	pe	INTJ
dpc-3965	150	7	ni	ni	PROPN
dpc-3965	150	8	ng	ng	PROPN
dpc-3965	151	1	c	c	PROPN
dpc-3965	151	2	ap	ap	PROPN
dpc-3965	151	3	ac	ac	VERB
dpc-3965	151	4	it	it	PRON
dpc-3965	151	5	y	y	NOUN
dpc-3965	151	6	;	;	PUNCT
dpc-3965	151	7	n	n	X
dpc-3965	151	8	/a	/a	PUNCT
dpc-3965	152	1	=	=	SYM
dpc-3965	152	2	n	n	PROPN
dpc-3965	152	3	ot	ot	VERB
dpc-3965	152	4	a	a	DET
dpc-3965	152	5	va	va	NOUN
dpc-3965	153	1	ila	ila	PROPN
dpc-3965	153	2	bl	bl	PROPN
dpc-3965	153	3	e	e	PROPN
dpc-3965	153	4	review	review	VERB
dpc-3965	153	5	|	|	ADV
dpc-3965	153	6	dermatol	dermatol	ADJ
dpc-3965	153	7	pract	pract	NOUN
dpc-3965	153	8	concept	concept	NOUN
dpc-3965	153	9	.	.	PUNCT
dpc-3965	154	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	154	2	5	5	NUM
dpc-3965	154	3	to	to	PART
dpc-3965	154	4	which	which	PRON
dpc-3965	154	5	glycosaminoglycans	glycosaminoglycan	NOUN
dpc-3965	154	6	(	(	PUNCT
dpc-3965	154	7	gag	gag	NOUN
dpc-3965	154	8	)	)	PUNCT
dpc-3965	154	9	attach	attach	VERB
dpc-3965	154	10	[	[	X
dpc-3965	154	11	17	17	NUM
dpc-3965	154	12	]	]	PUNCT
dpc-3965	154	13	.	.	PUNCT
dpc-3965	155	1	notably	notably	ADV
dpc-3965	155	2	,	,	PUNCT
dpc-3965	155	3	hyaluronic	hyaluronic	ADJ
dpc-3965	155	4	acid	acid	NOUN
dpc-3965	155	5	(	(	PUNCT
dpc-3965	155	6	ha	ha	INTJ
dpc-3965	155	7	)	)	PUNCT
dpc-3965	155	8	,	,	PUNCT
dpc-3965	155	9	a	a	DET
dpc-3965	155	10	linear	linear	ADJ
dpc-3965	155	11	gag	gag	NOUN
dpc-3965	155	12	composed	compose	VERB
dpc-3965	155	13	of	of	ADP
dpc-3965	155	14	alternating	alternate	VERB
dpc-3965	155	15	units	unit	NOUN
dpc-3965	155	16	of	of	ADP
dpc-3965	155	17	n	n	CCONJ
dpc-3965	155	18	-	-	PUNCT
dpc-3965	155	19	acetyl	acetyl	NOUN
dpc-3965	155	20	-	-	PUNCT
dpc-3965	155	21	d	d	NOUN
dpc-3965	155	22	-	-	NOUN
dpc-3965	155	23	glucosamine	glucosamine	NOUN
dpc-3965	155	24	and	and	CCONJ
dpc-3965	155	25	d	d	NOUN
dpc-3965	155	26	-	-	ADJ
dpc-3965	155	27	glucuronic	glucuronic	ADJ
dpc-3965	155	28	acid	acid	NOUN
dpc-3965	155	29	,	,	PUNCT
dpc-3965	155	30	is	be	AUX
dpc-3965	155	31	the	the	DET
dpc-3965	155	32	predominant	predominant	ADJ
dpc-3965	155	33	gag	gag	NOUN
dpc-3965	155	34	in	in	ADP
dpc-3965	155	35	the	the	DET
dpc-3965	155	36	dermis	dermis	NOUN
dpc-3965	155	37	due	due	ADP
dpc-3965	155	38	to	to	ADP
dpc-3965	155	39	its	its	PRON
dpc-3965	155	40	significant	significant	ADJ
dpc-3965	155	41	hydrophilic	hydrophilic	ADJ
dpc-3965	155	42	properties	property	NOUN
dpc-3965	155	43	,	,	PUNCT
dpc-3965	155	44	contributing	contribute	VERB
dpc-3965	155	45	largely	largely	ADV
dpc-3965	155	46	to	to	ADP
dpc-3965	155	47	the	the	DET
dpc-3965	155	48	cutaneous	cutaneous	ADJ
dpc-3965	155	49	viscoelastic	viscoelastic	ADJ
dpc-3965	155	50	properties	property	NOUN
dpc-3965	155	51	[	[	X
dpc-3965	155	52	17,18	17,18	X
dpc-3965	155	53	]	]	X
dpc-3965	155	54	.	.	PUNCT
dpc-3965	156	1	however	however	ADV
dpc-3965	156	2	,	,	PUNCT
dpc-3965	156	3	in	in	ADP
dpc-3965	156	4	the	the	DET
dpc-3965	156	5	context	context	NOUN
dpc-3965	156	6	of	of	ADP
dpc-3965	156	7	cutaneous	cutaneous	ADJ
dpc-3965	156	8	sclerosing	sclerose	VERB
dpc-3965	156	9	conditions	condition	NOUN
dpc-3965	156	10	such	such	ADJ
dpc-3965	156	11	as	as	ADP
dpc-3965	156	12	ssc	ssc	PROPN
dpc-3965	156	13	,	,	PUNCT
dpc-3965	156	14	an	an	DET
dpc-3965	156	15	abnormal	abnormal	ADJ
dpc-3965	156	16	accumulation	accumulation	NOUN
dpc-3965	156	17	of	of	ADP
dpc-3965	156	18	ha	ha	INTJ
dpc-3965	156	19	and	and	CCONJ
dpc-3965	156	20	collagen	collagen	NOUN
dpc-3965	156	21	within	within	ADP
dpc-3965	156	22	the	the	DET
dpc-3965	156	23	ecm	ecm	NOUN
dpc-3965	156	24	occurs	occur	VERB
dpc-3965	156	25	,	,	PUNCT
dpc-3965	156	26	ultimately	ultimately	ADV
dpc-3965	156	27	resulting	result	VERB
dpc-3965	156	28	in	in	ADP
dpc-3965	156	29	fibrosis	fibrosis	NOUN
dpc-3965	156	30	and	and	CCONJ
dpc-3965	156	31	scarring	scar	VERB
dpc-3965	156	32	[	[	X
dpc-3965	156	33	19	19	NUM
dpc-3965	156	34	]	]	PUNCT
dpc-3965	156	35	.	.	PUNCT
dpc-3965	157	1	to	to	PART
dpc-3965	157	2	address	address	VERB
dpc-3965	157	3	this	this	DET
dpc-3965	157	4	underlying	underlying	ADJ
dpc-3965	157	5	pathological	pathological	ADJ
dpc-3965	157	6	process	process	NOUN
dpc-3965	157	7	,	,	PUNCT
dpc-3965	157	8	treatment	treatment	NOUN
dpc-3965	157	9	with	with	ADP
dpc-3965	157	10	hyaluronidase	hyaluronidase	NOUN
dpc-3965	157	11	has	have	AUX
dpc-3965	157	12	been	be	AUX
dpc-3965	157	13	proposed	propose	VERB
dpc-3965	157	14	due	due	ADP
dpc-3965	157	15	to	to	ADP
dpc-3965	157	16	its	its	PRON
dpc-3965	157	17	ability	ability	NOUN
dpc-3965	157	18	to	to	PART
dpc-3965	157	19	hydrolyze	hydrolyze	VERB
dpc-3965	157	20	disaccharides	disaccharide	NOUN
dpc-3965	157	21	at	at	ADP
dpc-3965	157	22	hexosaminidase	hexosaminidase	ADJ
dpc-3965	157	23	linkages	linkage	NOUN
dpc-3965	157	24	,	,	PUNCT
dpc-3965	157	25	subsequently	subsequently	ADV
dpc-3965	157	26	degrading	degrade	VERB
dpc-3965	157	27	ecm	ecm	NOUN
dpc-3965	157	28	components	component	NOUN
dpc-3965	157	29	,	,	PUNCT
dpc-3965	157	30	improving	improve	VERB
dpc-3965	157	31	dermal	dermal	ADJ
dpc-3965	157	32	fibrosis	fibrosis	NOUN
dpc-3965	157	33	,	,	PUNCT
dpc-3965	157	34	and	and	CCONJ
dpc-3965	157	35	creating	create	VERB
dpc-3965	157	36	a	a	DET
dpc-3965	157	37	more	more	ADV
dpc-3965	157	38	favorable	favorable	ADJ
dpc-3965	157	39	environment	environment	NOUN
dpc-3965	157	40	for	for	ADP
dpc-3965	157	41	tissue	tissue	NOUN
dpc-3965	157	42	remodeling	remodeling	NOUN
dpc-3965	157	43	and	and	CCONJ
dpc-3965	157	44	repair	repair	NOUN
dpc-3965	157	45	[	[	X
dpc-3965	157	46	20	20	NUM
dpc-3965	157	47	]	]	PUNCT
dpc-3965	157	48	.	.	PUNCT
dpc-3965	158	1	it	it	PRON
dpc-3965	158	2	is	be	AUX
dpc-3965	158	3	crucial	crucial	ADJ
dpc-3965	158	4	to	to	PART
dpc-3965	158	5	understand	understand	VERB
dpc-3965	158	6	that	that	SCONJ
dpc-3965	158	7	the	the	DET
dpc-3965	158	8	underlying	underlying	ADJ
dpc-3965	158	9	mechanism	mechanism	NOUN
dpc-3965	158	10	of	of	ADP
dpc-3965	158	11	action	action	NOUN
dpc-3965	158	12	of	of	ADP
dpc-3965	158	13	hyaluronidase	hyaluronidase	NOUN
dpc-3965	158	14	in	in	ADP
dpc-3965	158	15	the	the	DET
dpc-3965	158	16	context	context	NOUN
dpc-3965	158	17	of	of	ADP
dpc-3965	158	18	improving	improve	VERB
dpc-3965	158	19	fibrosis	fibrosis	NOUN
dpc-3965	158	20	in	in	ADP
dpc-3965	158	21	ssc	ssc	NOUN
dpc-3965	158	22	patients	patient	NOUN
dpc-3965	158	23	is	be	AUX
dpc-3965	158	24	multifactorial	multifactorial	ADJ
dpc-3965	158	25	as	as	ADP
dpc-3965	158	26	it	it	PRON
dpc-3965	158	27	from	from	ADP
dpc-3965	158	28	3.0	3.0	NUM
dpc-3965	158	29	cm	cm	NOUN
dpc-3965	158	30	to	to	ADP
dpc-3965	158	31	4.5	4.5	NUM
dpc-3965	158	32	cm	cm	NOUN
dpc-3965	158	33	.	.	PUNCT
dpc-3965	159	1	in	in	ADP
dpc-3965	159	2	the	the	DET
dpc-3965	159	3	second	second	ADJ
dpc-3965	159	4	case	case	NOUN
dpc-3965	159	5	,	,	PUNCT
dpc-3965	159	6	the	the	DET
dpc-3965	159	7	ssc	ssc	NOUN
dpc-3965	159	8	patients	patient	NOUN
dpc-3965	159	9	received	receive	VERB
dpc-3965	159	10	33	33	NUM
dpc-3965	159	11	treatments	treatment	NOUN
dpc-3965	159	12	over	over	ADP
dpc-3965	159	13	3	3	NUM
dpc-3965	159	14	months	month	NOUN
dpc-3965	159	15	,	,	PUNCT
dpc-3965	159	16	resulting	result	VERB
dpc-3965	159	17	in	in	ADP
dpc-3965	159	18	9	9	NUM
dpc-3965	159	19	months	month	NOUN
dpc-3965	159	20	of	of	ADP
dpc-3965	159	21	improvement	improvement	NOUN
dpc-3965	159	22	in	in	ADP
dpc-3965	159	23	skin	skin	NOUN
dpc-3965	159	24	stiffness	stiffness	NOUN
dpc-3965	159	25	,	,	PUNCT
dpc-3965	159	26	color	color	NOUN
dpc-3965	159	27	,	,	PUNCT
dpc-3965	159	28	and	and	CCONJ
dpc-3965	159	29	cold	cold	ADJ
dpc-3965	159	30	intolerance	intolerance	NOUN
dpc-3965	159	31	related	relate	VERB
dpc-3965	159	32	to	to	ADP
dpc-3965	159	33	their	their	PRON
dpc-3965	159	34	raynaud	raynaud	NOUN
dpc-3965	159	35	syndrome	syndrome	NOUN
dpc-3965	159	36	.	.	PUNCT
dpc-3965	160	1	the	the	DET
dpc-3965	160	2	author	author	NOUN
dpc-3965	160	3	noted	note	VERB
dpc-3965	160	4	after	after	ADP
dpc-3965	160	5	3	3	NUM
dpc-3965	160	6	months	month	NOUN
dpc-3965	160	7	,	,	PUNCT
dpc-3965	160	8	the	the	DET
dpc-3965	160	9	therapeutic	therapeutic	ADJ
dpc-3965	160	10	benefit	benefit	NOUN
dpc-3965	160	11	of	of	ADP
dpc-3965	160	12	hyaluronidase	hyaluronidase	NOUN
dpc-3965	160	13	appeared	appear	VERB
dpc-3965	160	14	to	to	PART
dpc-3965	160	15	decrease	decrease	VERB
dpc-3965	160	16	,	,	PUNCT
dpc-3965	160	17	however	however	ADV
dpc-3965	160	18	,	,	PUNCT
dpc-3965	160	19	changing	change	VERB
dpc-3965	160	20	the	the	DET
dpc-3965	160	21	application	application	NOUN
dpc-3965	160	22	site	site	NOUN
dpc-3965	160	23	seemed	seem	VERB
dpc-3965	160	24	to	to	PART
dpc-3965	160	25	improve	improve	VERB
dpc-3965	160	26	this	this	DET
dpc-3965	160	27	finding	finding	NOUN
dpc-3965	160	28	.	.	PUNCT
dpc-3965	161	1	even	even	ADV
dpc-3965	161	2	after	after	ADP
dpc-3965	161	3	treatment	treatment	NOUN
dpc-3965	161	4	cessation	cessation	NOUN
dpc-3965	161	5	,	,	PUNCT
dpc-3965	161	6	the	the	DET
dpc-3965	161	7	severity	severity	NOUN
dpc-3965	161	8	of	of	ADP
dpc-3965	161	9	raynaud	raynaud	PROPN
dpc-3965	161	10	experienced	experience	VERB
dpc-3965	161	11	by	by	ADP
dpc-3965	161	12	each	each	DET
dpc-3965	161	13	patient	patient	NOUN
dpc-3965	161	14	remained	remain	VERB
dpc-3965	161	15	lower	low	ADJ
dpc-3965	161	16	than	than	ADP
dpc-3965	161	17	before	before	ADP
dpc-3965	161	18	starting	start	VERB
dpc-3965	161	19	hyaluronidase	hyaluronidase	ADJ
dpc-3965	161	20	treatment	treatment	NOUN
dpc-3965	161	21	[	[	X
dpc-3965	161	22	14	14	NUM
dpc-3965	161	23	]	]	PUNCT
dpc-3965	161	24	.	.	PUNCT
dpc-3965	162	1	discussion	discussion	NOUN
dpc-3965	162	2	the	the	DET
dpc-3965	162	3	ecm	ecm	NOUN
dpc-3965	162	4	of	of	ADP
dpc-3965	162	5	the	the	DET
dpc-3965	162	6	skin	skin	NOUN
dpc-3965	162	7	constitutes	constitute	VERB
dpc-3965	162	8	an	an	DET
dpc-3965	162	9	array	array	NOUN
dpc-3965	162	10	of	of	ADP
dpc-3965	162	11	macromolecules	macromolecule	NOUN
dpc-3965	162	12	,	,	PUNCT
dpc-3965	162	13	functioning	function	VERB
dpc-3965	162	14	not	not	PART
dpc-3965	162	15	only	only	ADV
dpc-3965	162	16	as	as	ADP
dpc-3965	162	17	the	the	DET
dpc-3965	162	18	structural	structural	ADJ
dpc-3965	162	19	scaffold	scaffold	NOUN
dpc-3965	162	20	but	but	CCONJ
dpc-3965	162	21	also	also	ADV
dpc-3965	162	22	as	as	ADP
dpc-3965	162	23	an	an	DET
dpc-3965	162	24	important	important	ADJ
dpc-3965	162	25	regulator	regulator	NOUN
dpc-3965	162	26	of	of	ADP
dpc-3965	162	27	several	several	ADJ
dpc-3965	162	28	cellular	cellular	ADJ
dpc-3965	162	29	processes	process	NOUN
dpc-3965	162	30	such	such	ADJ
dpc-3965	162	31	as	as	ADP
dpc-3965	162	32	proliferation	proliferation	NOUN
dpc-3965	162	33	,	,	PUNCT
dpc-3965	162	34	adhesion	adhesion	NOUN
dpc-3965	162	35	,	,	PUNCT
dpc-3965	162	36	migration	migration	NOUN
dpc-3965	162	37	,	,	PUNCT
dpc-3965	162	38	and	and	CCONJ
dpc-3965	162	39	gene	gene	NOUN
dpc-3965	162	40	expression	expression	NOUN
dpc-3965	162	41	[	[	X
dpc-3965	162	42	16	16	NUM
dpc-3965	162	43	]	]	PUNCT
dpc-3965	162	44	.	.	PUNCT
dpc-3965	163	1	it	it	PRON
dpc-3965	163	2	is	be	AUX
dpc-3965	163	3	primarily	primarily	ADV
dpc-3965	163	4	comprised	comprise	VERB
dpc-3965	163	5	of	of	ADP
dpc-3965	163	6	collagen	collagen	NOUN
dpc-3965	163	7	,	,	PUNCT
dpc-3965	163	8	elastin	elastin	NOUN
dpc-3965	163	9	,	,	PUNCT
dpc-3965	163	10	and	and	CCONJ
dpc-3965	163	11	proteoglycans	proteoglycan	NOUN
dpc-3965	163	12	figure	figure	VERB
dpc-3965	163	13	1	1	NUM
dpc-3965	163	14	.	.	PUNCT
dpc-3965	164	1	the	the	DET
dpc-3965	164	2	prisma	prisma	PROPN
dpc-3965	164	3	flow	flow	NOUN
dpc-3965	164	4	diagram	diagram	NOUN
dpc-3965	164	5	for	for	ADP
dpc-3965	164	6	the	the	DET
dpc-3965	164	7	systematic	systematic	ADJ
dpc-3965	164	8	review	review	NOUN
dpc-3965	164	9	detailing	detail	VERB
dpc-3965	164	10	database	database	NOUN
dpc-3965	164	11	search	search	NOUN
dpc-3965	164	12	,	,	PUNCT
dpc-3965	164	13	number	number	NOUN
dpc-3965	164	14	of	of	ADP
dpc-3965	164	15	title	title	NOUN
dpc-3965	164	16	and	and	CCONJ
dpc-3965	164	17	abstract	abstract	ADJ
dpc-3965	164	18	screens	screen	NOUN
dpc-3965	164	19	,	,	PUNCT
dpc-3965	164	20	full	full	ADJ
dpc-3965	164	21	text	text	NOUN
dpc-3965	164	22	screens	screen	NOUN
dpc-3965	164	23	,	,	PUNCT
dpc-3965	164	24	reasons	reason	NOUN
dpc-3965	164	25	for	for	ADP
dpc-3965	164	26	exclusion	exclusion	NOUN
dpc-3965	164	27	,	,	PUNCT
dpc-3965	164	28	and	and	CCONJ
dpc-3965	164	29	total	total	ADJ
dpc-3965	164	30	number	number	NOUN
dpc-3965	164	31	of	of	ADP
dpc-3965	164	32	articles	article	NOUN
dpc-3965	164	33	included	include	VERB
dpc-3965	164	34	in	in	ADP
dpc-3965	164	35	the	the	DET
dpc-3965	164	36	review	review	NOUN
dpc-3965	164	37	.	.	PUNCT
dpc-3965	165	1	6	6	NUM
dpc-3965	165	2	review	review	NOUN
dpc-3965	165	3	|	|	ADV
dpc-3965	165	4	dermatol	dermatol	ADJ
dpc-3965	165	5	pract	pract	NOUN
dpc-3965	165	6	concept	concept	NOUN
dpc-3965	165	7	.	.	PUNCT
dpc-3965	166	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	166	2	endpoint	endpoint	NOUN
dpc-3965	166	3	.	.	PUNCT
dpc-3965	167	1	however	however	ADV
dpc-3965	167	2	,	,	PUNCT
dpc-3965	167	3	measurement	measurement	NOUN
dpc-3965	167	4	varied	varied	ADJ
dpc-3965	167	5	between	between	ADP
dpc-3965	167	6	oral	oral	ADJ
dpc-3965	167	7	aperture	aperture	NOUN
dpc-3965	167	8	(	(	PUNCT
dpc-3965	167	9	inter	inter	ADJ
dpc-3965	167	10	-	-	ADJ
dpc-3965	167	11	incisional	incisional	ADJ
dpc-3965	167	12	opening	opening	NOUN
dpc-3965	167	13	versus	versus	ADP
dpc-3965	167	14	circumferential	circumferential	ADJ
dpc-3965	167	15	)	)	PUNCT
dpc-3965	167	16	or	or	CCONJ
dpc-3965	167	17	the	the	DET
dpc-3965	167	18	mhiss	mhiss	NOUN
dpc-3965	167	19	.	.	PUNCT
dpc-3965	168	1	in	in	ADP
dpc-3965	168	2	addition	addition	NOUN
dpc-3965	168	3	,	,	PUNCT
dpc-3965	168	4	each	each	DET
dpc-3965	168	5	study	study	NOUN
dpc-3965	168	6	varied	varied	ADJ
dpc-3965	168	7	in	in	ADP
dpc-3965	168	8	the	the	DET
dpc-3965	168	9	volume	volume	NOUN
dpc-3965	168	10	of	of	ADP
dpc-3965	168	11	hyaluronidase	hyaluronidase	NOUN
dpc-3965	168	12	used	use	VERB
dpc-3965	168	13	per	per	ADP
dpc-3965	168	14	injection	injection	NOUN
dpc-3965	168	15	,	,	PUNCT
dpc-3965	168	16	number	number	NOUN
dpc-3965	168	17	of	of	ADP
dpc-3965	168	18	injections	injection	NOUN
dpc-3965	168	19	per	per	ADP
dpc-3965	168	20	session	session	NOUN
dpc-3965	168	21	,	,	PUNCT
dpc-3965	168	22	and	and	CCONJ
dpc-3965	168	23	potential	potential	ADJ
dpc-3965	168	24	additives	additive	NOUN
dpc-3965	168	25	—	—	PUNCT
dpc-3965	168	26	such	such	ADJ
dpc-3965	168	27	as	as	ADP
dpc-3965	168	28	one	one	NUM
dpc-3965	168	29	case	case	NOUN
dpc-3965	168	30	that	that	PRON
dpc-3965	168	31	mixed	mix	VERB
dpc-3965	168	32	hyaluronidase	hyaluronidase	NOUN
dpc-3965	168	33	with	with	ADP
dpc-3965	168	34	dexamethasone	dexamethasone	NOUN
dpc-3965	168	35	.	.	PUNCT
dpc-3965	169	1	however	however	ADV
dpc-3965	169	2	,	,	PUNCT
dpc-3965	169	3	cases	case	NOUN
dpc-3965	169	4	consistently	consistently	ADV
dpc-3965	169	5	showed	show	VERB
dpc-3965	169	6	positive	positive	ADJ
dpc-3965	169	7	results	result	NOUN
dpc-3965	169	8	regarding	regard	VERB
dpc-3965	169	9	either	either	CCONJ
dpc-3965	169	10	increased	increase	VERB
dpc-3965	169	11	oral	oral	ADJ
dpc-3965	169	12	aperture	aperture	NOUN
dpc-3965	169	13	or	or	CCONJ
dpc-3965	169	14	mhiss	mhiss	ADJ
dpc-3965	169	15	,	,	PUNCT
dpc-3965	169	16	with	with	ADP
dpc-3965	169	17	reported	report	VERB
dpc-3965	169	18	side	side	NOUN
dpc-3965	169	19	effects	effect	NOUN
dpc-3965	169	20	limited	limit	VERB
dpc-3965	169	21	to	to	ADP
dpc-3965	169	22	temporary	temporary	ADJ
dpc-3965	169	23	injection	injection	NOUN
dpc-3965	169	24	site	site	NOUN
dpc-3965	169	25	reactions	reaction	NOUN
dpc-3965	169	26	.	.	PUNCT
dpc-3965	170	1	this	this	PRON
dpc-3965	170	2	makes	make	VERB
dpc-3965	170	3	hyaluronidase	hyaluronidase	NOUN
dpc-3965	170	4	a	a	DET
dpc-3965	170	5	promising	promising	ADJ
dpc-3965	170	6	treatment	treatment	NOUN
dpc-3965	170	7	for	for	ADP
dpc-3965	170	8	ssc	ssc	NOUN
dpc-3965	170	9	-	-	PUNCT
dpc-3965	170	10	related	relate	VERB
dpc-3965	170	11	microstomia	microstomia	NOUN
dpc-3965	170	12	.	.	PUNCT
dpc-3965	171	1	the	the	DET
dpc-3965	171	2	most	most	ADV
dpc-3965	171	3	common	common	ADJ
dpc-3965	171	4	volume	volume	NOUN
dpc-3965	171	5	of	of	ADP
dpc-3965	171	6	injection	injection	NOUN
dpc-3965	171	7	seen	see	VERB
dpc-3965	171	8	was	be	AUX
dpc-3965	171	9	0.1cc	0.1cc	PROPN
dpc-3965	171	10	/	/	SYM
dpc-3965	171	11	ml	ml	NOUN
dpc-3965	171	12	of	of	ADP
dpc-3965	171	13	hyaluronidase	hyaluronidase	NOUN
dpc-3965	171	14	,	,	PUNCT
dpc-3965	171	15	in	in	ADP
dpc-3965	171	16	multiple	multiple	ADJ
dpc-3965	171	17	injection	injection	NOUN
dpc-3965	171	18	points	point	NOUN
dpc-3965	171	19	in	in	ADP
dpc-3965	171	20	sclerotic	sclerotic	ADJ
dpc-3965	171	21	lesions	lesion	NOUN
dpc-3965	171	22	around	around	ADP
dpc-3965	171	23	the	the	DET
dpc-3965	171	24	mouth	mouth	NOUN
dpc-3965	171	25	,	,	PUNCT
dpc-3965	171	26	not	not	PART
dpc-3965	171	27	entering	enter	VERB
dpc-3965	171	28	the	the	DET
dpc-3965	171	29	lip	lip	NOUN
dpc-3965	171	30	border	border	NOUN
dpc-3965	171	31	.	.	PUNCT
dpc-3965	172	1	most	most	ADJ
dpc-3965	172	2	clinicians	clinician	NOUN
dpc-3965	172	3	opted	opt	VERB
dpc-3965	172	4	to	to	PART
dpc-3965	172	5	have	have	VERB
dpc-3965	172	6	multiple	multiple	ADJ
dpc-3965	172	7	rounds	round	NOUN
dpc-3965	172	8	of	of	ADP
dpc-3965	172	9	injections	injection	NOUN
dpc-3965	172	10	with	with	ADP
dpc-3965	172	11	a	a	DET
dpc-3965	172	12	few	few	ADJ
dpc-3965	172	13	weeks	week	NOUN
dpc-3965	172	14	of	of	ADP
dpc-3965	172	15	interval	interval	NOUN
dpc-3965	172	16	in	in	ADP
dpc-3965	172	17	between	between	ADP
dpc-3965	172	18	to	to	PART
dpc-3965	172	19	confirm	confirm	VERB
dpc-3965	172	20	no	no	DET
dpc-3965	172	21	adverse	adverse	ADJ
dpc-3965	172	22	side	side	NOUN
dpc-3965	172	23	effects	effect	NOUN
dpc-3965	172	24	and	and	CCONJ
dpc-3965	172	25	clinical	clinical	ADJ
dpc-3965	172	26	improvement	improvement	NOUN
dpc-3965	172	27	.	.	PUNCT
dpc-3965	173	1	the	the	DET
dpc-3965	173	2	recent	recent	ADJ
dpc-3965	173	3	case	case	NOUN
dpc-3965	173	4	series	series	NOUN
dpc-3965	173	5	published	publish	VERB
dpc-3965	173	6	by	by	ADP
dpc-3965	173	7	min	min	PROPN
dpc-3965	173	8	et	et	PROPN
dpc-3965	173	9	al	al	PROPN
dpc-3965	173	10	.	.	PUNCT
dpc-3965	173	11	demonstrating	demonstrate	VERB
dpc-3965	173	12	a	a	DET
dpc-3965	173	13	standard	standard	ADJ
dpc-3965	173	14	protocol	protocol	NOUN
dpc-3965	173	15	of	of	ADP
dpc-3965	173	16	hyaluronidase	hyaluronidase	ADJ
dpc-3965	173	17	injection	injection	NOUN
dpc-3965	173	18	for	for	ADP
dpc-3965	173	19	3	3	NUM
dpc-3965	173	20	patients	patient	NOUN
dpc-3965	173	21	with	with	ADP
dpc-3965	173	22	ssc	ssc	NOUN
dpc-3965	173	23	microstomia	microstomia	NOUN
dpc-3965	173	24	provides	provide	VERB
dpc-3965	173	25	a	a	DET
dpc-3965	173	26	useful	useful	ADJ
dpc-3965	173	27	template	template	NOUN
dpc-3965	173	28	for	for	ADP
dpc-3965	173	29	clinicians	clinician	NOUN
dpc-3965	173	30	and	and	CCONJ
dpc-3965	173	31	researchers	researcher	NOUN
dpc-3965	173	32	to	to	PART
dpc-3965	173	33	build	build	VERB
dpc-3965	173	34	upon	upon	SCONJ
dpc-3965	173	35	[	[	X
dpc-3965	173	36	13	13	NUM
dpc-3965	173	37	]	]	PUNCT
dpc-3965	173	38	.	.	PUNCT
dpc-3965	174	1	yet	yet	ADV
dpc-3965	174	2	,	,	PUNCT
dpc-3965	174	3	the	the	DET
dpc-3965	174	4	potential	potential	NOUN
dpc-3965	174	5	for	for	ADP
dpc-3965	174	6	hyaluronidase	hyaluronidase	NOUN
dpc-3965	174	7	in	in	ADP
dpc-3965	174	8	ssc	ssc	NOUN
dpc-3965	174	9	-	-	PUNCT
dpc-3965	174	10	related	relate	VERB
dpc-3965	174	11	symptoms	symptom	NOUN
dpc-3965	174	12	likely	likely	ADV
dpc-3965	174	13	extends	extend	VERB
dpc-3965	174	14	beyond	beyond	ADP
dpc-3965	174	15	microstomia	microstomia	NOUN
dpc-3965	174	16	.	.	PUNCT
dpc-3965	175	1	this	this	PRON
dpc-3965	175	2	was	be	AUX
dpc-3965	175	3	earlier	early	ADV
dpc-3965	175	4	demonstrated	demonstrate	VERB
dpc-3965	175	5	in	in	ADP
dpc-3965	175	6	1951	1951	NUM
dpc-3965	175	7	,	,	PUNCT
dpc-3965	175	8	where	where	SCONJ
dpc-3965	175	9	ssc	ssc	NOUN
dpc-3965	175	10	patients	patient	NOUN
dpc-3965	175	11	treated	treat	VERB
dpc-3965	175	12	with	with	ADP
dpc-3965	175	13	iontophoretic	iontophoretic	ADJ
dpc-3965	175	14	hyaluronidase	hyaluronidase	PROPN
dpc-3965	175	15	noted	note	VERB
dpc-3965	175	16	improvement	improvement	NOUN
dpc-3965	175	17	in	in	ADP
dpc-3965	175	18	sclerodactyly	sclerodactyly	PROPN
dpc-3965	175	19	,	,	PUNCT
dpc-3965	175	20	raynaud	raynaud	PROPN
dpc-3965	175	21	syndrome	syndrome	PROPN
dpc-3965	175	22	,	,	PUNCT
dpc-3965	175	23	and	and	CCONJ
dpc-3965	175	24	general	general	ADJ
dpc-3965	175	25	skin	skin	NOUN
dpc-3965	175	26	stiffness	stiffness	NOUN
dpc-3965	175	27	in	in	ADP
dpc-3965	175	28	addition	addition	NOUN
dpc-3965	175	29	to	to	ADP
dpc-3965	175	30	microstomia	microstomia	NOUN
dpc-3965	176	1	[	[	X
dpc-3965	176	2	15	15	NUM
dpc-3965	176	3	]	]	PUNCT
dpc-3965	176	4	.	.	PUNCT
dpc-3965	177	1	one	one	NUM
dpc-3965	177	2	consideration	consideration	NOUN
dpc-3965	177	3	noted	note	VERB
dpc-3965	177	4	from	from	ADP
dpc-3965	177	5	the	the	DET
dpc-3965	177	6	1951	1951	NUM
dpc-3965	177	7	popkin	popkin	NOUN
dpc-3965	177	8	case	case	NOUN
dpc-3965	177	9	series	series	NOUN
dpc-3965	177	10	was	be	AUX
dpc-3965	177	11	the	the	DET
dpc-3965	177	12	perceived	perceive	VERB
dpc-3965	177	13	decreased	decrease	VERB
dpc-3965	177	14	efficacy	efficacy	NOUN
dpc-3965	177	15	of	of	ADP
dpc-3965	177	16	hyaluronidase	hyaluronidase	NOUN
dpc-3965	177	17	usage	usage	NOUN
dpc-3965	177	18	over	over	ADP
dpc-3965	177	19	time	time	NOUN
dpc-3965	177	20	,	,	PUNCT
dpc-3965	177	21	in	in	ADP
dpc-3965	177	22	which	which	PRON
dpc-3965	177	23	after	after	ADP
dpc-3965	177	24	3	3	NUM
dpc-3965	177	25	months	month	NOUN
dpc-3965	177	26	the	the	DET
dpc-3965	177	27	clinician	clinician	NOUN
dpc-3965	177	28	halted	halt	VERB
dpc-3965	177	29	treatments	treatment	NOUN
dpc-3965	177	30	due	due	ADJ
dpc-3965	177	31	to	to	ADP
dpc-3965	177	32	diminishing	diminish	VERB
dpc-3965	177	33	returns	return	NOUN
dpc-3965	177	34	[	[	X
dpc-3965	177	35	15	15	NUM
dpc-3965	177	36	]	]	PUNCT
dpc-3965	177	37	.	.	PUNCT
dpc-3965	178	1	this	this	DET
dpc-3965	178	2	plateau	plateau	NOUN
dpc-3965	178	3	effect	effect	NOUN
dpc-3965	178	4	was	be	AUX
dpc-3965	178	5	also	also	ADV
dpc-3965	178	6	seen	see	VERB
dpc-3965	178	7	by	by	ADP
dpc-3965	178	8	min	min	PROPN
dpc-3965	178	9	et	et	PROPN
dpc-3965	178	10	al	al	PROPN
dpc-3965	178	11	,	,	PUNCT
dpc-3965	178	12	who	who	PRON
dpc-3965	178	13	noticed	notice	VERB
dpc-3965	178	14	diminished	diminish	VERB
dpc-3965	178	15	returns	return	NOUN
dpc-3965	178	16	after	after	ADP
dpc-3965	178	17	3	3	NUM
dpc-3965	178	18	-	-	SYM
dpc-3965	178	19	5	5	NUM
dpc-3965	178	20	rounds	round	NOUN
dpc-3965	178	21	of	of	ADP
dpc-3965	178	22	monthly	monthly	ADJ
dpc-3965	178	23	injections	injection	NOUN
dpc-3965	178	24	.	.	PUNCT
dpc-3965	179	1	despite	despite	SCONJ
dpc-3965	179	2	this	this	PRON
dpc-3965	179	3	,	,	PUNCT
dpc-3965	179	4	the	the	DET
dpc-3965	179	5	patients	patient	NOUN
dpc-3965	179	6	described	describe	VERB
dpc-3965	179	7	maintained	maintain	VERB
dpc-3965	179	8	greater	great	ADJ
dpc-3965	179	9	oral	oral	ADJ
dpc-3965	179	10	aperture	aperture	NOUN
dpc-3965	179	11	for	for	ADP
dpc-3965	179	12	at	at	ADV
dpc-3965	179	13	least	least	ADV
dpc-3965	179	14	6	6	NUM
dpc-3965	179	15	-	-	SYM
dpc-3965	179	16	9	9	NUM
dpc-3965	179	17	months	month	NOUN
dpc-3965	179	18	after	after	ADP
dpc-3965	179	19	their	their	PRON
dpc-3965	179	20	last	last	ADJ
dpc-3965	179	21	injection	injection	NOUN
dpc-3965	179	22	[	[	X
dpc-3965	179	23	13,15	13,15	NUM
dpc-3965	179	24	]	]	PUNCT
dpc-3965	179	25	.	.	PUNCT
dpc-3965	180	1	while	while	SCONJ
dpc-3965	180	2	other	other	ADJ
dpc-3965	180	3	studies	study	NOUN
dpc-3965	180	4	did	do	AUX
dpc-3965	180	5	not	not	PART
dpc-3965	180	6	notice	notice	VERB
dpc-3965	180	7	diminishing	diminishing	NOUN
dpc-3965	180	8	returns	return	NOUN
dpc-3965	180	9	from	from	ADP
dpc-3965	180	10	increased	increase	VERB
dpc-3965	180	11	injections	injection	NOUN
dpc-3965	180	12	at	at	ADP
dpc-3965	180	13	the	the	DET
dpc-3965	180	14	time	time	NOUN
dpc-3965	180	15	of	of	ADP
dpc-3965	180	16	publication	publication	NOUN
dpc-3965	180	17	,	,	PUNCT
dpc-3965	180	18	the	the	DET
dpc-3965	180	19	investigators	investigator	NOUN
dpc-3965	180	20	in	in	ADP
dpc-3965	180	21	those	those	DET
dpc-3965	180	22	studies	study	NOUN
dpc-3965	180	23	did	do	AUX
dpc-3965	180	24	not	not	PART
dpc-3965	180	25	establish	establish	VERB
dpc-3965	180	26	plateau	plateau	NOUN
dpc-3965	180	27	effect	effect	NOUN
dpc-3965	180	28	as	as	ADP
dpc-3965	180	29	an	an	DET
dpc-3965	180	30	endpoint	endpoint	NOUN
dpc-3965	180	31	.	.	PUNCT
dpc-3965	181	1	despite	despite	SCONJ
dpc-3965	181	2	this	this	DET
dpc-3965	181	3	promising	promising	ADJ
dpc-3965	181	4	feature	feature	NOUN
dpc-3965	181	5	,	,	PUNCT
dpc-3965	181	6	the	the	DET
dpc-3965	181	7	literature	literature	NOUN
dpc-3965	181	8	regarding	regard	VERB
dpc-3965	181	9	hyaluronidase	hyaluronidase	NOUN
dpc-3965	181	10	and	and	CCONJ
dpc-3965	181	11	ssc	ssc	NOUN
dpc-3965	181	12	has	have	AUX
dpc-3965	181	13	been	be	AUX
dpc-3965	181	14	sparse	sparse	ADJ
dpc-3965	181	15	.	.	PUNCT
dpc-3965	182	1	in	in	ADP
dpc-3965	182	2	our	our	PRON
dpc-3965	182	3	initial	initial	ADJ
dpc-3965	182	4	pubmed	pubmed	NOUN
dpc-3965	182	5	search	search	NOUN
dpc-3965	182	6	over	over	ADP
dpc-3965	182	7	all	all	DET
dpc-3965	182	8	years	year	NOUN
dpc-3965	182	9	,	,	PUNCT
dpc-3965	182	10	only	only	ADV
dpc-3965	182	11	43	43	NUM
dpc-3965	182	12	studies	study	NOUN
dpc-3965	182	13	presented	present	VERB
dpc-3965	182	14	with	with	ADP
dpc-3965	182	15	the	the	DET
dpc-3965	182	16	search	search	NOUN
dpc-3965	182	17	terms	term	NOUN
dpc-3965	182	18	“	"	PUNCT
dpc-3965	182	19	hyaluronidase	hyaluronidase	NOUN
dpc-3965	182	20	”	"	PUNCT
dpc-3965	182	21	and	and	CCONJ
dpc-3965	182	22	“	"	PUNCT
dpc-3965	182	23	scleroderma	scleroderma	NOUN
dpc-3965	182	24	.	.	PUNCT
dpc-3965	182	25	”	"	PUNCT
dpc-3965	183	1	notably	notably	ADV
dpc-3965	183	2	,	,	PUNCT
dpc-3965	183	3	none	none	NOUN
dpc-3965	183	4	of	of	ADP
dpc-3965	183	5	these	these	DET
dpc-3965	183	6	studies	study	NOUN
dpc-3965	183	7	were	be	AUX
dpc-3965	183	8	classified	classify	VERB
dpc-3965	183	9	as	as	ADP
dpc-3965	183	10	a	a	DET
dpc-3965	183	11	randomized	randomized	ADJ
dpc-3965	183	12	control	control	NOUN
dpc-3965	183	13	trial	trial	NOUN
dpc-3965	183	14	.	.	PUNCT
dpc-3965	184	1	in	in	ADP
dpc-3965	184	2	addition	addition	NOUN
dpc-3965	184	3	,	,	PUNCT
dpc-3965	184	4	some	some	DET
dpc-3965	184	5	studies	study	NOUN
dpc-3965	184	6	such	such	ADJ
dpc-3965	184	7	as	as	ADP
dpc-3965	184	8	that	that	PRON
dpc-3965	184	9	from	from	ADP
dpc-3965	184	10	min	min	PROPN
dpc-3965	184	11	et	et	PROPN
dpc-3965	184	12	al	al	PROPN
dpc-3965	184	13	.	.	PROPN
dpc-3965	184	14	combines	combine	VERB
dpc-3965	184	15	the	the	DET
dpc-3965	184	16	results	result	NOUN
dpc-3965	184	17	of	of	ADP
dpc-3965	184	18	hyaluronidase	hyaluronidase	NOUN
dpc-3965	184	19	in	in	ADP
dpc-3965	184	20	ssc	ssc	NOUN
dpc-3965	184	21	with	with	ADP
dpc-3965	184	22	other	other	ADJ
dpc-3965	184	23	sclerosing	sclerose	VERB
dpc-3965	184	24	diseases	disease	NOUN
dpc-3965	184	25	,	,	PUNCT
dpc-3965	184	26	making	make	VERB
dpc-3965	184	27	it	it	PRON
dpc-3965	184	28	difficult	difficult	ADJ
dpc-3965	184	29	to	to	PART
dpc-3965	184	30	accurately	accurately	ADV
dpc-3965	184	31	appreciate	appreciate	VERB
dpc-3965	184	32	the	the	DET
dpc-3965	184	33	effect	effect	NOUN
dpc-3965	184	34	within	within	ADP
dpc-3965	184	35	ssc	ssc	PROPN
dpc-3965	184	36	.	.	PUNCT
dpc-3965	185	1	similarly	similarly	ADV
dpc-3965	185	2	,	,	PUNCT
dpc-3965	185	3	no	no	DET
dpc-3965	185	4	identified	identify	VERB
dpc-3965	185	5	randomized	randomized	ADJ
dpc-3965	185	6	control	control	NOUN
dpc-3965	185	7	trial	trial	NOUN
dpc-3965	185	8	was	be	AUX
dpc-3965	185	9	seen	see	VERB
dpc-3965	185	10	in	in	ADP
dpc-3965	185	11	the	the	DET
dpc-3965	185	12	embase	embase	ADJ
dpc-3965	185	13	search	search	NOUN
dpc-3965	185	14	over	over	ADP
dpc-3965	185	15	all	all	DET
dpc-3965	185	16	years	year	NOUN
dpc-3965	185	17	.	.	PUNCT
dpc-3965	186	1	in	in	ADP
dpc-3965	186	2	addition	addition	NOUN
dpc-3965	186	3	,	,	PUNCT
dpc-3965	186	4	all	all	DET
dpc-3965	186	5	recent	recent	ADJ
dpc-3965	186	6	reports	report	NOUN
dpc-3965	186	7	only	only	ADV
dpc-3965	186	8	consider	consider	VERB
dpc-3965	186	9	the	the	DET
dpc-3965	186	10	use	use	NOUN
dpc-3965	186	11	of	of	ADP
dpc-3965	186	12	hyaluronidase	hyaluronidase	NOUN
dpc-3965	186	13	in	in	ADP
dpc-3965	186	14	microstomia	microstomia	NOUN
dpc-3965	186	15	.	.	PUNCT
dpc-3965	187	1	while	while	SCONJ
dpc-3965	187	2	one	one	NUM
dpc-3965	187	3	cohort	cohort	NOUN
dpc-3965	187	4	study	study	NOUN
dpc-3965	187	5	considered	consider	VERB
dpc-3965	187	6	its	its	PRON
dpc-3965	187	7	use	use	NOUN
dpc-3965	187	8	in	in	ADP
dpc-3965	187	9	general	general	ADJ
dpc-3965	187	10	ssc	ssc	NOUN
dpc-3965	187	11	skin	skin	NOUN
dpc-3965	187	12	damage	damage	NOUN
dpc-3965	187	13	,	,	PUNCT
dpc-3965	187	14	this	this	PRON
dpc-3965	187	15	was	be	AUX
dpc-3965	187	16	a	a	DET
dpc-3965	187	17	conference	conference	NOUN
dpc-3965	187	18	abstract	abstract	NOUN
dpc-3965	187	19	without	without	ADP
dpc-3965	187	20	definitive	definitive	ADJ
dpc-3965	187	21	results	result	NOUN
dpc-3965	187	22	provided	provide	VERB
dpc-3965	187	23	.	.	PUNCT
dpc-3965	188	1	this	this	PRON
dpc-3965	188	2	indicates	indicate	VERB
dpc-3965	188	3	a	a	DET
dpc-3965	188	4	significant	significant	ADJ
dpc-3965	188	5	lack	lack	NOUN
dpc-3965	188	6	of	of	ADP
dpc-3965	188	7	research	research	NOUN
dpc-3965	188	8	in	in	ADP
dpc-3965	188	9	this	this	DET
dpc-3965	188	10	potential	potential	ADJ
dpc-3965	188	11	treatment	treatment	NOUN
dpc-3965	188	12	triggers	trigger	VERB
dpc-3965	188	13	various	various	ADJ
dpc-3965	188	14	downstream	downstream	ADJ
dpc-3965	188	15	effects	effect	NOUN
dpc-3965	188	16	upon	upon	SCONJ
dpc-3965	188	17	breaking	break	VERB
dpc-3965	188	18	down	down	ADP
dpc-3965	188	19	hyaluronic	hyaluronic	ADJ
dpc-3965	188	20	acid	acid	NOUN
dpc-3965	188	21	.	.	PUNCT
dpc-3965	189	1	the	the	DET
dpc-3965	189	2	disruption	disruption	NOUN
dpc-3965	189	3	of	of	ADP
dpc-3965	189	4	the	the	DET
dpc-3965	189	5	ha	ha	INTJ
dpc-3965	189	6	barrier	barrier	NOUN
dpc-3965	189	7	plays	play	VERB
dpc-3965	189	8	a	a	DET
dpc-3965	189	9	pivotal	pivotal	ADJ
dpc-3965	189	10	role	role	NOUN
dpc-3965	189	11	in	in	ADP
dpc-3965	189	12	facilitating	facilitate	VERB
dpc-3965	189	13	the	the	DET
dpc-3965	189	14	delivery	delivery	NOUN
dpc-3965	189	15	of	of	ADP
dpc-3965	189	16	therapeutic	therapeutic	ADJ
dpc-3965	189	17	agents	agent	NOUN
dpc-3965	189	18	into	into	ADP
dpc-3965	189	19	affected	affected	ADJ
dpc-3965	189	20	tissues	tissue	NOUN
dpc-3965	189	21	[	[	X
dpc-3965	189	22	21	21	NUM
dpc-3965	189	23	]	]	PUNCT
dpc-3965	189	24	.	.	PUNCT
dpc-3965	190	1	furthermore	furthermore	ADV
dpc-3965	190	2	,	,	PUNCT
dpc-3965	190	3	hyaluronidase	hyaluronidase	ADJ
dpc-3965	190	4	capacity	capacity	NOUN
dpc-3965	190	5	to	to	PART
dpc-3965	190	6	degrade	degrade	VERB
dpc-3965	190	7	ha	ha	INTJ
dpc-3965	190	8	also	also	ADV
dpc-3965	190	9	acts	act	VERB
dpc-3965	190	10	as	as	ADP
dpc-3965	190	11	a	a	DET
dpc-3965	190	12	potential	potential	ADJ
dpc-3965	190	13	modulator	modulator	NOUN
dpc-3965	190	14	of	of	ADP
dpc-3965	190	15	the	the	DET
dpc-3965	190	16	immune	immune	ADJ
dpc-3965	190	17	system	system	NOUN
dpc-3965	190	18	,	,	PUNCT
dpc-3965	190	19	contributing	contribute	VERB
dpc-3965	190	20	to	to	ADP
dpc-3965	190	21	inflammation	inflammation	ADJ
dpc-3965	190	22	reduction	reduction	NOUN
dpc-3965	190	23	.	.	PUNCT
dpc-3965	191	1	through	through	ADP
dpc-3965	191	2	the	the	DET
dpc-3965	191	3	alteration	alteration	NOUN
dpc-3965	191	4	of	of	ADP
dpc-3965	191	5	the	the	DET
dpc-3965	191	6	proinflammatory	proinflammatory	ADJ
dpc-3965	191	7	environment	environment	NOUN
dpc-3965	191	8	within	within	ADP
dpc-3965	191	9	affected	affected	ADJ
dpc-3965	191	10	tissues	tissue	NOUN
dpc-3965	191	11	,	,	PUNCT
dpc-3965	191	12	it	it	PRON
dpc-3965	191	13	can	can	AUX
dpc-3965	191	14	effectively	effectively	ADV
dpc-3965	191	15	regulate	regulate	VERB
dpc-3965	191	16	immune	immune	ADJ
dpc-3965	191	17	cell	cell	NOUN
dpc-3965	191	18	activity	activity	NOUN
dpc-3965	191	19	and	and	CCONJ
dpc-3965	191	20	cytokine	cytokine	NOUN
dpc-3965	191	21	production	production	NOUN
dpc-3965	191	22	,	,	PUNCT
dpc-3965	191	23	potentially	potentially	ADV
dpc-3965	191	24	reducing	reduce	VERB
dpc-3965	191	25	the	the	DET
dpc-3965	191	26	severity	severity	NOUN
dpc-3965	191	27	of	of	ADP
dpc-3965	191	28	the	the	DET
dpc-3965	191	29	condition	condition	NOUN
dpc-3965	191	30	[	[	X
dpc-3965	191	31	22	22	NUM
dpc-3965	191	32	]	]	PUNCT
dpc-3965	191	33	.	.	PUNCT
dpc-3965	192	1	limited	limited	ADJ
dpc-3965	192	2	contraindications	contraindication	NOUN
dpc-3965	192	3	exist	exist	VERB
dpc-3965	192	4	for	for	ADP
dpc-3965	192	5	the	the	DET
dpc-3965	192	6	use	use	NOUN
dpc-3965	192	7	of	of	ADP
dpc-3965	192	8	hyaluronidase	hyaluronidase	NOUN
dpc-3965	192	9	in	in	ADP
dpc-3965	192	10	ssc	ssc	PROPN
dpc-3965	192	11	,	,	PUNCT
dpc-3965	192	12	however	however	ADV
dpc-3965	192	13	,	,	PUNCT
dpc-3965	192	14	hypersensitivity	hypersensitivity	NOUN
dpc-3965	192	15	to	to	ADP
dpc-3965	192	16	the	the	DET
dpc-3965	192	17	material	material	NOUN
dpc-3965	192	18	or	or	CCONJ
dpc-3965	192	19	other	other	ADJ
dpc-3965	192	20	injection	injection	NOUN
dpc-3965	192	21	ingredients	ingredient	NOUN
dpc-3965	192	22	can	can	AUX
dpc-3965	192	23	occur	occur	VERB
dpc-3965	192	24	in	in	ADP
dpc-3965	192	25	some	some	DET
dpc-3965	192	26	patients	patient	NOUN
dpc-3965	193	1	[	[	X
dpc-3965	193	2	23	23	NUM
dpc-3965	193	3	]	]	PUNCT
dpc-3965	193	4	.	.	PUNCT
dpc-3965	194	1	some	some	DET
dpc-3965	194	2	research	research	NOUN
dpc-3965	194	3	suggests	suggest	VERB
dpc-3965	194	4	hyalornidase	hyalornidase	NOUN
dpc-3965	194	5	can	can	AUX
dpc-3965	194	6	be	be	AUX
dpc-3965	194	7	pro	pro	ADJ
dpc-3965	194	8	-	-	ADJ
dpc-3965	194	9	thrombogenic	thrombogenic	ADJ
dpc-3965	194	10	,	,	PUNCT
dpc-3965	194	11	and	and	CCONJ
dpc-3965	194	12	therefore	therefore	ADV
dpc-3965	194	13	cautionary	cautionary	ADJ
dpc-3965	194	14	use	use	NOUN
dpc-3965	194	15	is	be	AUX
dpc-3965	194	16	recommended	recommend	VERB
dpc-3965	194	17	in	in	ADP
dpc-3965	194	18	patients	patient	NOUN
dpc-3965	194	19	with	with	ADP
dpc-3965	194	20	hypercoagulable	hypercoagulable	ADJ
dpc-3965	194	21	conditions	condition	NOUN
dpc-3965	194	22	[	[	X
dpc-3965	194	23	23	23	NUM
dpc-3965	194	24	]	]	PUNCT
dpc-3965	194	25	.	.	PUNCT
dpc-3965	195	1	risk	risk	NOUN
dpc-3965	195	2	in	in	ADP
dpc-3965	195	3	pregnancy	pregnancy	NOUN
dpc-3965	195	4	has	have	AUX
dpc-3965	195	5	not	not	PART
dpc-3965	195	6	been	be	AUX
dpc-3965	195	7	well	well	ADV
dpc-3965	195	8	-	-	PUNCT
dpc-3965	195	9	elucidated	elucidated	ADJ
dpc-3965	195	10	.	.	PUNCT
dpc-3965	196	1	numerous	numerous	ADJ
dpc-3965	196	2	case	case	NOUN
dpc-3965	196	3	reports	report	NOUN
dpc-3965	196	4	have	have	AUX
dpc-3965	196	5	demonstrated	demonstrate	VERB
dpc-3965	196	6	hyaluronidase	hyaluronidase	ADJ
dpc-3965	196	7	efficacy	efficacy	NOUN
dpc-3965	196	8	in	in	ADP
dpc-3965	196	9	enhancing	enhance	VERB
dpc-3965	196	10	overall	overall	ADJ
dpc-3965	196	11	quality	quality	NOUN
dpc-3965	196	12	of	of	ADP
dpc-3965	196	13	life	life	NOUN
dpc-3965	196	14	for	for	ADP
dpc-3965	196	15	ssc	ssc	NOUN
dpc-3965	196	16	patients	patient	NOUN
dpc-3965	196	17	by	by	ADP
dpc-3965	196	18	enhancing	enhance	VERB
dpc-3965	196	19	both	both	CCONJ
dpc-3965	196	20	the	the	DET
dpc-3965	196	21	aesthetic	aesthetic	ADJ
dpc-3965	196	22	appearance	appearance	NOUN
dpc-3965	196	23	and	and	CCONJ
dpc-3965	196	24	associated	associate	VERB
dpc-3965	196	25	functional	functional	ADJ
dpc-3965	196	26	impairments	impairment	NOUN
dpc-3965	196	27	such	such	ADJ
dpc-3965	196	28	as	as	ADP
dpc-3965	196	29	microstomia	microstomia	NOUN
dpc-3965	196	30	.	.	PUNCT
dpc-3965	197	1	while	while	SCONJ
dpc-3965	197	2	a	a	DET
dpc-3965	197	3	thorough	thorough	ADJ
dpc-3965	197	4	exploration	exploration	NOUN
dpc-3965	197	5	of	of	ADP
dpc-3965	197	6	various	various	ADJ
dpc-3965	197	7	aspects	aspect	NOUN
dpc-3965	197	8	of	of	ADP
dpc-3965	197	9	quality	quality	NOUN
dpc-3965	197	10	of	of	ADP
dpc-3965	197	11	life	life	NOUN
dpc-3965	197	12	was	be	AUX
dpc-3965	197	13	not	not	PART
dpc-3965	197	14	explicitly	explicitly	ADV
dpc-3965	197	15	detailed	detail	VERB
dpc-3965	197	16	in	in	ADP
dpc-3965	197	17	all	all	DET
dpc-3965	197	18	case	case	NOUN
dpc-3965	197	19	reports	report	VERB
dpc-3965	197	20	,	,	PUNCT
dpc-3965	197	21	it	it	PRON
dpc-3965	197	22	is	be	AUX
dpc-3965	197	23	well	well	ADV
dpc-3965	197	24	-	-	PUNCT
dpc-3965	197	25	established	establish	VERB
dpc-3965	197	26	that	that	SCONJ
dpc-3965	197	27	microstomia	microstomia	NOUN
dpc-3965	197	28	significantly	significantly	ADV
dpc-3965	197	29	impacts	impact	VERB
dpc-3965	197	30	everyday	everyday	ADJ
dpc-3965	197	31	functioning	functioning	NOUN
dpc-3965	197	32	:	:	PUNCT
dpc-3965	197	33	mastication	mastication	NOUN
dpc-3965	197	34	,	,	PUNCT
dpc-3965	197	35	speech	speech	NOUN
dpc-3965	197	36	,	,	PUNCT
dpc-3965	197	37	oral	oral	ADJ
dpc-3965	197	38	hygiene	hygiene	NOUN
dpc-3965	197	39	practices	practice	NOUN
dpc-3965	197	40	[	[	X
dpc-3965	197	41	3,5	3,5	NUM
dpc-3965	197	42	]	]	PUNCT
dpc-3965	197	43	.	.	PUNCT
dpc-3965	198	1	in	in	ADP
dpc-3965	198	2	some	some	DET
dpc-3965	198	3	cases	case	NOUN
dpc-3965	198	4	reviewed	review	VERB
dpc-3965	198	5	in	in	ADP
dpc-3965	198	6	this	this	DET
dpc-3965	198	7	article	article	NOUN
dpc-3965	198	8	,	,	PUNCT
dpc-3965	198	9	decreased	decrease	VERB
dpc-3965	198	10	quality	quality	NOUN
dpc-3965	198	11	of	of	ADP
dpc-3965	198	12	life	life	NOUN
dpc-3965	198	13	due	due	ADP
dpc-3965	198	14	to	to	ADP
dpc-3965	198	15	difficulty	difficulty	NOUN
dpc-3965	198	16	eating	eat	VERB
dpc-3965	198	17	,	,	PUNCT
dpc-3965	198	18	talking	talk	VERB
dpc-3965	198	19	,	,	PUNCT
dpc-3965	198	20	sleeping	sleeping	NOUN
dpc-3965	198	21	,	,	PUNCT
dpc-3965	198	22	and	and	CCONJ
dpc-3965	198	23	poor	poor	ADJ
dpc-3965	198	24	self	self	NOUN
dpc-3965	198	25	-	-	PUNCT
dpc-3965	198	26	image	image	NOUN
dpc-3965	198	27	was	be	AUX
dpc-3965	198	28	reported	report	VERB
dpc-3965	198	29	[	[	X
dpc-3965	198	30	9,11	9,11	X
dpc-3965	198	31	]	]	PUNCT
dpc-3965	198	32	.	.	PUNCT
dpc-3965	199	1	the	the	DET
dpc-3965	199	2	improvement	improvement	NOUN
dpc-3965	199	3	of	of	ADP
dpc-3965	199	4	patients	patient	NOUN
dpc-3965	199	5	oral	oral	ADJ
dpc-3965	199	6	function	function	NOUN
dpc-3965	199	7	and	and	CCONJ
dpc-3965	199	8	appearance	appearance	NOUN
dpc-3965	199	9	through	through	ADP
dpc-3965	199	10	hyaluronidase	hyaluronidase	NOUN
dpc-3965	199	11	injections	injection	NOUN
dpc-3965	199	12	positively	positively	ADV
dpc-3965	199	13	impacting	impact	VERB
dpc-3965	199	14	a	a	DET
dpc-3965	199	15	patient	patient	ADJ
dpc-3965	199	16	quality	quality	NOUN
dpc-3965	199	17	of	of	ADP
dpc-3965	199	18	life	life	NOUN
dpc-3965	199	19	was	be	AUX
dpc-3965	199	20	subsequently	subsequently	ADV
dpc-3965	199	21	documented	document	VERB
dpc-3965	199	22	in	in	ADP
dpc-3965	199	23	the	the	DET
dpc-3965	199	24	results	result	NOUN
dpc-3965	199	25	.	.	PUNCT
dpc-3965	200	1	therefore	therefore	ADV
dpc-3965	200	2	,	,	PUNCT
dpc-3965	200	3	it	it	PRON
dpc-3965	200	4	is	be	AUX
dpc-3965	200	5	important	important	ADJ
dpc-3965	200	6	to	to	PART
dpc-3965	200	7	note	note	VERB
dpc-3965	200	8	that	that	SCONJ
dpc-3965	200	9	symptomatic	symptomatic	ADJ
dpc-3965	200	10	improvement	improvement	NOUN
dpc-3965	200	11	of	of	ADP
dpc-3965	200	12	this	this	DET
dpc-3965	200	13	microstomia	microstomia	NOUN
dpc-3965	200	14	can	can	AUX
dpc-3965	200	15	have	have	VERB
dpc-3965	200	16	profound	profound	ADJ
dpc-3965	200	17	outcomes	outcome	NOUN
dpc-3965	200	18	not	not	PART
dpc-3965	200	19	fully	fully	ADV
dpc-3965	200	20	measured	measure	VERB
dpc-3965	200	21	by	by	ADP
dpc-3965	200	22	increased	increase	VERB
dpc-3965	200	23	oral	oral	ADJ
dpc-3965	200	24	aperture	aperture	NOUN
dpc-3965	200	25	,	,	PUNCT
dpc-3965	200	26	such	such	ADJ
dpc-3965	200	27	as	as	ADP
dpc-3965	200	28	improved	improved	ADJ
dpc-3965	200	29	nutrition	nutrition	NOUN
dpc-3965	200	30	and	and	CCONJ
dpc-3965	200	31	increased	increase	VERB
dpc-3965	200	32	ability	ability	NOUN
dpc-3965	200	33	to	to	PART
dpc-3965	200	34	socialize	socialize	VERB
dpc-3965	200	35	.	.	PUNCT
dpc-3965	201	1	although	although	SCONJ
dpc-3965	201	2	many	many	ADJ
dpc-3965	201	3	studies	study	NOUN
dpc-3965	201	4	do	do	AUX
dpc-3965	201	5	suggest	suggest	VERB
dpc-3965	201	6	promising	promising	ADJ
dpc-3965	201	7	results	result	NOUN
dpc-3965	201	8	for	for	ADP
dpc-3965	201	9	various	various	ADJ
dpc-3965	201	10	ssc	ssc	NOUN
dpc-3965	201	11	manifestations	manifestation	NOUN
dpc-3965	201	12	,	,	PUNCT
dpc-3965	201	13	including	include	VERB
dpc-3965	201	14	morphea	morphea	NOUN
dpc-3965	201	15	and	and	CCONJ
dpc-3965	201	16	microstomia	microstomia	NOUN
dpc-3965	201	17	,	,	PUNCT
dpc-3965	201	18	these	these	PRON
dpc-3965	201	19	are	be	AUX
dpc-3965	201	20	isolated	isolate	VERB
dpc-3965	201	21	case	case	NOUN
dpc-3965	201	22	reports	report	NOUN
dpc-3965	201	23	and	and	CCONJ
dpc-3965	201	24	standardized	standardized	ADJ
dpc-3965	201	25	trials	trial	NOUN
dpc-3965	201	26	.	.	PUNCT
dpc-3965	202	1	therefore	therefore	ADV
dpc-3965	202	2	,	,	PUNCT
dpc-3965	202	3	these	these	DET
dpc-3965	202	4	studies	study	NOUN
dpc-3965	202	5	lack	lack	VERB
dpc-3965	202	6	strength	strength	NOUN
dpc-3965	202	7	to	to	PART
dpc-3965	202	8	validate	validate	VERB
dpc-3965	202	9	its	its	PRON
dpc-3965	202	10	use	use	NOUN
dpc-3965	202	11	as	as	ADP
dpc-3965	202	12	a	a	DET
dpc-3965	202	13	first	first	ADJ
dpc-3965	202	14	-	-	PUNCT
dpc-3965	202	15	line	line	NOUN
dpc-3965	202	16	treatment	treatment	NOUN
dpc-3965	202	17	option	option	NOUN
dpc-3965	202	18	for	for	ADP
dpc-3965	202	19	symptoms	symptom	NOUN
dpc-3965	202	20	associated	associate	VERB
dpc-3965	202	21	with	with	ADP
dpc-3965	202	22	ssc	ssc	PROPN
dpc-3965	202	23	.	.	PUNCT
dpc-3965	203	1	however	however	ADV
dpc-3965	203	2	,	,	PUNCT
dpc-3965	203	3	one	one	PRON
dpc-3965	203	4	can	can	AUX
dpc-3965	203	5	reasonably	reasonably	ADV
dpc-3965	203	6	conclude	conclude	VERB
dpc-3965	203	7	that	that	SCONJ
dpc-3965	203	8	hyaluronidase	hyaluronidase	NOUN
dpc-3965	203	9	may	may	AUX
dpc-3965	203	10	serve	serve	VERB
dpc-3965	203	11	as	as	ADP
dpc-3965	203	12	a	a	DET
dpc-3965	203	13	valuable	valuable	ADJ
dpc-3965	203	14	alternative	alternative	NOUN
dpc-3965	203	15	when	when	SCONJ
dpc-3965	203	16	conventional	conventional	ADJ
dpc-3965	203	17	approaches	approach	NOUN
dpc-3965	203	18	prove	prove	VERB
dpc-3965	203	19	ineffective	ineffective	ADJ
dpc-3965	203	20	,	,	PUNCT
dpc-3965	203	21	offering	offer	VERB
dpc-3965	203	22	hope	hope	NOUN
dpc-3965	203	23	to	to	ADP
dpc-3965	203	24	these	these	DET
dpc-3965	203	25	patients	patient	NOUN
dpc-3965	203	26	.	.	PUNCT
dpc-3965	204	1	additionally	additionally	ADV
dpc-3965	204	2	,	,	PUNCT
dpc-3965	204	3	the	the	DET
dpc-3965	204	4	flexibility	flexibility	NOUN
dpc-3965	204	5	in	in	ADP
dpc-3965	204	6	dosing	dosing	NOUN
dpc-3965	204	7	and	and	CCONJ
dpc-3965	204	8	administration	administration	NOUN
dpc-3965	204	9	allows	allow	VERB
dpc-3965	204	10	for	for	ADP
dpc-3965	204	11	individualized	individualized	ADJ
dpc-3965	204	12	treatment	treatment	NOUN
dpc-3965	204	13	plans	plan	NOUN
dpc-3965	204	14	tailored	tailor	VERB
dpc-3965	204	15	to	to	ADP
dpc-3965	204	16	each	each	DET
dpc-3965	204	17	patient	patient	ADJ
dpc-3965	204	18	unique	unique	ADJ
dpc-3965	204	19	clinical	clinical	ADJ
dpc-3965	204	20	presentation	presentation	NOUN
dpc-3965	204	21	.	.	PUNCT
dpc-3965	205	1	the	the	DET
dpc-3965	205	2	limitations	limitation	NOUN
dpc-3965	205	3	of	of	ADP
dpc-3965	205	4	these	these	DET
dpc-3965	205	5	studies	study	NOUN
dpc-3965	205	6	include	include	VERB
dpc-3965	205	7	the	the	DET
dpc-3965	205	8	variation	variation	NOUN
dpc-3965	205	9	in	in	ADP
dpc-3965	205	10	their	their	PRON
dpc-3965	205	11	administration	administration	NOUN
dpc-3965	205	12	and	and	CCONJ
dpc-3965	205	13	formulation	formulation	NOUN
dpc-3965	205	14	of	of	ADP
dpc-3965	205	15	hyaluronidase	hyaluronidase	NOUN
dpc-3965	205	16	,	,	PUNCT
dpc-3965	205	17	lack	lack	NOUN
dpc-3965	205	18	of	of	ADP
dpc-3965	205	19	clear	clear	ADJ
dpc-3965	205	20	improvement	improvement	NOUN
dpc-3965	205	21	metrics	metric	NOUN
dpc-3965	205	22	,	,	PUNCT
dpc-3965	205	23	and	and	CCONJ
dpc-3965	205	24	small	small	ADJ
dpc-3965	205	25	cohort	cohort	NOUN
dpc-3965	205	26	size	size	NOUN
dpc-3965	205	27	,	,	PUNCT
dpc-3965	205	28	as	as	SCONJ
dpc-3965	205	29	previously	previously	ADV
dpc-3965	205	30	shown	show	VERB
dpc-3965	205	31	in	in	ADP
dpc-3965	205	32	table	table	NOUN
dpc-3965	205	33	1	1	NUM
dpc-3965	205	34	.	.	PUNCT
dpc-3965	206	1	most	most	ADJ
dpc-3965	206	2	of	of	ADP
dpc-3965	206	3	the	the	DET
dpc-3965	206	4	studies	study	NOUN
dpc-3965	206	5	were	be	AUX
dpc-3965	206	6	case	case	NOUN
dpc-3965	206	7	reports	report	NOUN
dpc-3965	206	8	on	on	ADP
dpc-3965	206	9	the	the	DET
dpc-3965	206	10	use	use	NOUN
dpc-3965	206	11	of	of	ADP
dpc-3965	206	12	hyaluronidase	hyaluronidase	NOUN
dpc-3965	206	13	in	in	ADP
dpc-3965	206	14	microstomia	microstomia	NOUN
dpc-3965	206	15	that	that	PRON
dpc-3965	206	16	mentioned	mention	VERB
dpc-3965	206	17	improvement	improvement	NOUN
dpc-3965	206	18	in	in	ADP
dpc-3965	206	19	oral	oral	ADJ
dpc-3965	206	20	aperture	aperture	NOUN
dpc-3965	206	21	as	as	ADP
dpc-3965	206	22	a	a	DET
dpc-3965	206	23	therapeutic	therapeutic	ADJ
dpc-3965	206	24	review	review	NOUN
dpc-3965	206	25	|	|	ADV
dpc-3965	206	26	dermatol	dermatol	ADJ
dpc-3965	206	27	pract	pract	NOUN
dpc-3965	206	28	concept	concept	NOUN
dpc-3965	206	29	.	.	PUNCT
dpc-3965	207	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	207	2	7	7	NUM
dpc-3965	207	3	2	2	NUM
dpc-3965	207	4	.	.	PUNCT
dpc-3965	207	5	crincoli	crincoli	PROPN
dpc-3965	207	6	v	v	NOUN
dpc-3965	207	7	,	,	PUNCT
dpc-3965	207	8	fatone	fatone	PROPN
dpc-3965	207	9	l	l	PROPN
dpc-3965	207	10	,	,	PUNCT
dpc-3965	207	11	fanelli	fanelli	PROPN
dpc-3965	207	12	m	m	PROPN
dpc-3965	207	13	,	,	PUNCT
dpc-3965	207	14	et	et	PROPN
dpc-3965	207	15	al	al	PROPN
dpc-3965	207	16	.	.	PUNCT
dpc-3965	207	17	orofacial	orofacial	ADJ
dpc-3965	207	18	manifestations	manifestation	NOUN
dpc-3965	207	19	and	and	CCONJ
dpc-3965	207	20	temporomandibular	temporomandibular	ADJ
dpc-3965	207	21	disorders	disorder	NOUN
dpc-3965	207	22	of	of	ADP
dpc-3965	207	23	systemic	systemic	ADJ
dpc-3965	207	24	scleroderma	scleroderma	NOUN
dpc-3965	207	25	:	:	PUNCT
dpc-3965	207	26	an	an	DET
dpc-3965	207	27	observational	observational	ADJ
dpc-3965	207	28	study	study	NOUN
dpc-3965	207	29	.	.	PUNCT
dpc-3965	208	1	int	int	PROPN
dpc-3965	208	2	j	j	PROPN
dpc-3965	208	3	mol	mol	ADP
dpc-3965	208	4	sci	sci	PROPN
dpc-3965	208	5	.	.	PUNCT
dpc-3965	209	1	2016;17(7):1189	2016;17(7):1189	NUM
dpc-3965	209	2	.	.	PUNCT
dpc-3965	210	1	doi	doi	NOUN
dpc-3965	210	2	:	:	PUNCT
dpc-3965	210	3	10.3390	10.3390	NUM
dpc-3965	210	4	/	/	SYM
dpc-3965	210	5	ijms17071189	ijms17071189	PROPN
dpc-3965	210	6	.	.	PUNCT
dpc-3965	211	1	pmid	pmid	NOUN
dpc-3965	211	2	:	:	PUNCT
dpc-3965	211	3	27455250	27455250	NUM
dpc-3965	211	4	.	.	PUNCT
dpc-3965	212	1	pmcid	pmcid	ADJ
dpc-3965	212	2	:	:	PUNCT
dpc-3965	212	3	pmc4964558	pmc4964558	ADJ
dpc-3965	212	4	.	.	PUNCT
dpc-3965	213	1	3	3	X
dpc-3965	213	2	.	.	X
dpc-3965	213	3	hadj	hadj	PROPN
dpc-3965	213	4	said	say	VERB
dpc-3965	213	5	m	m	PROPN
dpc-3965	213	6	,	,	PUNCT
dpc-3965	213	7	foletti	foletti	PROPN
dpc-3965	213	8	jm	jm	PROPN
dpc-3965	213	9	,	,	PUNCT
dpc-3965	213	10	graillon	graillon	PROPN
dpc-3965	213	11	n	n	PART
dpc-3965	213	12	,	,	PUNCT
dpc-3965	213	13	guyot	guyot	PROPN
dpc-3965	213	14	l	l	PROPN
dpc-3965	213	15	,	,	PUNCT
dpc-3965	213	16	chossegros	chossegros	PROPN
dpc-3965	213	17	c.	c.	PROPN
dpc-3965	213	18	orofacial	orofacial	ADJ
dpc-3965	213	19	manifestations	manifestation	NOUN
dpc-3965	213	20	of	of	ADP
dpc-3965	213	21	scleroderma	scleroderma	NOUN
dpc-3965	213	22	.	.	PUNCT
dpc-3965	214	1	a	a	DET
dpc-3965	214	2	literature	literature	PROPN
dpc-3965	214	3	review	review	NOUN
dpc-3965	214	4	.	.	PUNCT
dpc-3965	215	1	rev	rev	AUX
dpc-3965	215	2	stomatol	stomatol	VERB
dpc-3965	215	3	chir	chir	ADJ
dpc-3965	215	4	maxillo	maxillo	PROPN
dpc-3965	215	5	-	-	PUNCT
dpc-3965	215	6	faciale	faciale	NOUN
dpc-3965	215	7	chir	chir	ADJ
dpc-3965	215	8	orale	orale	PROPN
dpc-3965	215	9	.	.	PROPN
dpc-3965	216	1	2016;117(5	2016;117(5	NUM
dpc-3965	216	2	):	):	PUNCT
dpc-3965	216	3	322	322	NUM
dpc-3965	216	4	-	-	SYM
dpc-3965	216	5	326	326	NUM
dpc-3965	216	6	.	.	PUNCT
dpc-3965	217	1	doi:10.1016	doi:10.1016	PROPN
dpc-3965	217	2	/	/	SYM
dpc-3965	217	3	j.revsto.2016.06.003	j.revsto.2016.06.003	PROPN
dpc-3965	217	4	.	.	PUNCT
dpc-3965	218	1	pmid	pmid	PROPN
dpc-3965	218	2	:	:	PUNCT
dpc-3965	218	3	 	 	SPACE
dpc-3965	218	4	27475503	27475503	NUM
dpc-3965	218	5	4	4	NUM
dpc-3965	218	6	.	.	PUNCT
dpc-3965	219	1	poole	poole	PROPN
dpc-3965	219	2	j	j	PROPN
dpc-3965	219	3	,	,	PUNCT
dpc-3965	219	4	conte	conte	PROPN
dpc-3965	219	5	c	c	NOUN
dpc-3965	219	6	,	,	PUNCT
dpc-3965	219	7	brewer	brewer	NOUN
dpc-3965	219	8	c	c	NOUN
dpc-3965	219	9	,	,	PUNCT
dpc-3965	219	10	et	et	PROPN
dpc-3965	219	11	al	al	PROPN
dpc-3965	219	12	.	.	PUNCT
dpc-3965	219	13	oral	oral	ADJ
dpc-3965	219	14	hygiene	hygiene	NOUN
dpc-3965	219	15	in	in	ADP
dpc-3965	219	16	scleroderma	scleroderma	NOUN
dpc-3965	219	17	:	:	PUNCT
dpc-3965	219	18	the	the	DET
dpc-3965	219	19	effectiveness	effectiveness	NOUN
dpc-3965	219	20	of	of	ADP
dpc-3965	219	21	a	a	DET
dpc-3965	219	22	multi	multi	ADJ
dpc-3965	219	23	-	-	ADJ
dpc-3965	219	24	disciplinary	disciplinary	ADJ
dpc-3965	219	25	intervention	intervention	NOUN
dpc-3965	219	26	program	program	NOUN
dpc-3965	219	27	.	.	PUNCT
dpc-3965	220	1	disabil	disabil	PROPN
dpc-3965	220	2	rehabil	rehabil	PROPN
dpc-3965	220	3	.	.	PUNCT
dpc-3965	221	1	2010;32(5):379	2010;32(5):379	NUM
dpc-3965	221	2	-	-	SYM
dpc-3965	221	3	384	384	NUM
dpc-3965	221	4	.	.	PUNCT
dpc-3965	221	5	doi:10.3109	doi:10.3109	PROPN
dpc-3965	221	6	/09638280903171527	/09638280903171527	PUNCT
dpc-3965	221	7	.	.	PUNCT
dpc-3965	222	1	pmid	pmid	NOUN
dpc-3965	222	2	:	:	PUNCT
dpc-3965	222	3	19852714	19852714	NUM
dpc-3965	222	4	5	5	NUM
dpc-3965	222	5	.	.	PUNCT
dpc-3965	223	1	baron	baron	PROPN
dpc-3965	223	2	m	m	PROPN
dpc-3965	223	3	,	,	PUNCT
dpc-3965	223	4	hudson	hudson	PROPN
dpc-3965	223	5	m	m	PROPN
dpc-3965	223	6	,	,	PUNCT
dpc-3965	223	7	steele	steele	PROPN
dpc-3965	223	8	r	r	PROPN
dpc-3965	223	9	,	,	PUNCT
dpc-3965	223	10	canadian	canadian	ADJ
dpc-3965	223	11	scleroderma	scleroderma	NOUN
dpc-3965	223	12	research	research	NOUN
dpc-3965	223	13	group	group	NOUN
dpc-3965	223	14	.	.	PUNCT
dpc-3965	224	1	malnutrition	malnutrition	NOUN
dpc-3965	224	2	is	be	AUX
dpc-3965	224	3	common	common	ADJ
dpc-3965	224	4	in	in	ADP
dpc-3965	224	5	systemic	systemic	ADJ
dpc-3965	224	6	sclerosis	sclerosis	NOUN
dpc-3965	224	7	:	:	PUNCT
dpc-3965	224	8	results	result	NOUN
dpc-3965	224	9	from	from	ADP
dpc-3965	224	10	the	the	DET
dpc-3965	224	11	canadian	canadian	ADJ
dpc-3965	224	12	scleroderma	scleroderma	PROPN
dpc-3965	224	13	research	research	NOUN
dpc-3965	224	14	group	group	NOUN
dpc-3965	224	15	database	database	NOUN
dpc-3965	224	16	.	.	PUNCT
dpc-3965	225	1	j	j	PROPN
dpc-3965	225	2	rheumatol	rheumatol	NOUN
dpc-3965	225	3	.	.	PUNCT
dpc-3965	226	1	2009;36(12):2737	2009;36(12):2737	NUM
dpc-3965	226	2	-	-	SYM
dpc-3965	226	3	2743	2743	NUM
dpc-3965	226	4	.	.	PUNCT
dpc-3965	227	1	doi:10.3899	doi:10.3899	NOUN
dpc-3965	227	2	/	/	SYM
dpc-3965	227	3	jrheum	jrheum	NOUN
dpc-3965	227	4	.090694	.090694	PROPN
dpc-3965	227	5	.	.	PUNCT
dpc-3965	228	1	pmid	pmid	NOUN
dpc-3965	228	2	:	:	PUNCT
dpc-3965	228	3	 	 	SPACE
dpc-3965	228	4	19833750	19833750	NUM
dpc-3965	228	5	6	6	NUM
dpc-3965	228	6	.	.	PUNCT
dpc-3965	228	7	kaul	kaul	PROPN
dpc-3965	228	8	a	a	PRON
dpc-3965	228	9	,	,	PUNCT
dpc-3965	228	10	short	short	ADJ
dpc-3965	228	11	wd	wd	PROPN
dpc-3965	228	12	,	,	PUNCT
dpc-3965	228	13	wang	wang	PROPN
dpc-3965	228	14	x	x	PROPN
dpc-3965	228	15	,	,	PUNCT
dpc-3965	228	16	keswani	keswani	PROPN
dpc-3965	228	17	sg	sg	PROPN
dpc-3965	228	18	.	.	PUNCT
dpc-3965	229	1	hyaluronidases	hyaluronidase	NOUN
dpc-3965	229	2	in	in	ADP
dpc-3965	229	3	human	human	ADJ
dpc-3965	229	4	diseases	disease	NOUN
dpc-3965	229	5	.	.	PUNCT
dpc-3965	230	1	int	int	PROPN
dpc-3965	230	2	j	j	PROPN
dpc-3965	230	3	mol	mol	ADP
dpc-3965	230	4	sci	sci	PROPN
dpc-3965	230	5	.	.	PUNCT
dpc-3965	231	1	2021;22(6):3204	2021;22(6):3204	NUM
dpc-3965	231	2	.	.	PUNCT
dpc-3965	231	3	doi:10.3390	doi:10.3390	NOUN
dpc-3965	231	4	/ijms22063204	/ijms22063204	PUNCT
dpc-3965	231	5	.	.	PUNCT
dpc-3965	232	1	pmid	pmid	NOUN
dpc-3965	232	2	:	:	PUNCT
dpc-3965	232	3	 	 	SPACE
dpc-3965	232	4	33809827	33809827	NUM
dpc-3965	232	5	 	 	SPACE
dpc-3965	232	6	pmcid	pmcid	NOUN
dpc-3965	232	7	:	:	PUNCT
dpc-3965	232	8	 	 	SPACE
dpc-3965	232	9	pmc8004219	pmc8004219	NOUN
dpc-3965	232	10	7	7	NUM
dpc-3965	232	11	.	.	PUNCT
dpc-3965	232	12	e	e	PROPN
dpc-3965	232	13	kilic	kilic	NOUN
dpc-3965	232	14	,	,	PUNCT
dpc-3965	232	15	g	g	PROPN
dpc-3965	232	16	kilic	kilic	NOUN
dpc-3965	232	17	,	,	PUNCT
dpc-3965	232	18	g	g	PROPN
dpc-3965	232	19	karadas	karada	NOUN
dpc-3965	232	20	.	.	PUNCT
dpc-3965	233	1	ab0210	ab0210	ADJ
dpc-3965	233	2	serum	serum	NOUN
dpc-3965	233	3	and	and	CCONJ
dpc-3965	233	4	tissue	tissue	NOUN
dpc-3965	233	5	levels	level	NOUN
dpc-3965	233	6	of	of	ADP
dpc-3965	233	7	hyaluronan	hyaluronan	PROPN
dpc-3965	233	8	in	in	ADP
dpc-3965	233	9	patients	patient	NOUN
dpc-3965	233	10	with	with	ADP
dpc-3965	233	11	systemic	systemic	ADJ
dpc-3965	233	12	sclerosis	sclerosis	NOUN
dpc-3965	233	13	.	.	PUNCT
dpc-3965	234	1	annals	annal	NOUN
dpc-3965	234	2	of	of	ADP
dpc-3965	234	3	the	the	DET
dpc-3965	234	4	rheumatic	rheumatic	ADJ
dpc-3965	234	5	diseases	disease	NOUN
dpc-3965	234	6	.	.	PUNCT
dpc-3965	235	1	2015;74:961	2015;74:961	NUM
dpc-3965	235	2	.	.	NOUN
dpc-3965	235	3	8	8	NUM
dpc-3965	235	4	.	.	X
dpc-3965	235	5	abbas	abbas	PROPN
dpc-3965	235	6	lf	lf	PROPN
dpc-3965	235	7	,	,	PUNCT
dpc-3965	235	8	coias	coias	PROPN
dpc-3965	235	9	j	j	PROPN
dpc-3965	235	10	,	,	PUNCT
dpc-3965	235	11	jacobe	jacobe	PROPN
dpc-3965	235	12	ht	ht	PROPN
dpc-3965	235	13	,	,	PUNCT
dpc-3965	235	14	nijhawan	nijhawan	PROPN
dpc-3965	235	15	ri	ri	PROPN
dpc-3965	235	16	.	.	PUNCT
dpc-3965	235	17	hyaluronidase	hyaluronidase	VERB
dpc-3965	235	18	injections	injection	NOUN
dpc-3965	235	19	for	for	ADP
dpc-3965	235	20	treatment	treatment	NOUN
dpc-3965	235	21	of	of	ADP
dpc-3965	235	22	symptomatic	symptomatic	ADJ
dpc-3965	235	23	pansclerotic	pansclerotic	ADJ
dpc-3965	235	24	morphea	morphea	NOUN
dpc-3965	235	25	-	-	PUNCT
dpc-3965	235	26	induced	induce	VERB
dpc-3965	235	27	microstomia	microstomia	NOUN
dpc-3965	235	28	.	.	PUNCT
dpc-3965	236	1	jaad	jaad	NOUN
dpc-3965	236	2	case	case	NOUN
dpc-3965	236	3	rep	rep	PROPN
dpc-3965	236	4	.	.	PROPN
dpc-3965	236	5	2019;5(10	2019;5(10	NUM
dpc-3965	236	6	):	):	PUNCT
dpc-3965	237	1	871	871	NUM
dpc-3965	237	2	-	-	SYM
dpc-3965	237	3	873	873	NUM
dpc-3965	237	4	.	.	PUNCT
dpc-3965	237	5	doi:10.1016	doi:10.1016	PROPN
dpc-3965	237	6	/	/	SYM
dpc-3965	237	7	j.jdcr.2019.08.004	j.jdcr.2019.08.004	PROPN
dpc-3965	237	8	.	.	PUNCT
dpc-3965	238	1	pmid	pmid	NOUN
dpc-3965	238	2	:	:	PUNCT
dpc-3965	238	3	  	  	SPACE
dpc-3965	238	4	31649976	31649976	NUM
dpc-3965	238	5	pmcid	pmcid	NOUN
dpc-3965	238	6	:	:	PUNCT
dpc-3965	238	7	 	 	SPACE
dpc-3965	238	8	pmc6804562	pmc6804562	PROPN
dpc-3965	238	9	9	9	NUM
dpc-3965	238	10	.	.	PUNCT
dpc-3965	239	1	chopra	chopra	PROPN
dpc-3965	239	2	d	d	PROPN
dpc-3965	239	3	,	,	PUNCT
dpc-3965	239	4	brehm	brehm	PROPN
dpc-3965	239	5	je	je	PROPN
dpc-3965	239	6	,	,	PUNCT
dpc-3965	239	7	morrison	morrison	PROPN
dpc-3965	239	8	b.	b.	PROPN
dpc-3965	239	9	hyaluronidase	hyaluronidase	PROPN
dpc-3965	239	10	as	as	ADP
dpc-3965	239	11	a	a	DET
dpc-3965	239	12	successful	successful	ADJ
dpc-3965	239	13	treatment	treatment	NOUN
dpc-3965	239	14	modality	modality	NOUN
dpc-3965	239	15	for	for	ADP
dpc-3965	239	16	scleroderma	scleroderma	NOUN
dpc-3965	239	17	-	-	PUNCT
dpc-3965	239	18	induced	induce	VERB
dpc-3965	239	19	microstomia	microstomia	NOUN
dpc-3965	239	20	.	.	PUNCT
dpc-3965	240	1	dermatol	dermatol	NOUN
dpc-3965	240	2	surg	surg	NOUN
dpc-3965	240	3	off	off	ADP
dpc-3965	240	4	publ	publ	NOUN
dpc-3965	240	5	am	be	AUX
dpc-3965	240	6	soc	soc	NOUN
dpc-3965	240	7	dermatol	dermatol	NOUN
dpc-3965	240	8	surg	surg	PROPN
dpc-3965	240	9	al	al	PROPN
dpc-3965	240	10	.	.	PUNCT
dpc-3965	241	1	2022;48(9):1014	2022;48(9):1014	NUM
dpc-3965	241	2	-	-	SYM
dpc-3965	241	3	1015	1015	NUM
dpc-3965	241	4	.	.	PUNCT
dpc-3965	242	1	doi:10.1097	doi:10.1097	NOUN
dpc-3965	242	2	/	/	SYM
dpc-3965	242	3	dss.0000000000003543	dss.0000000000003543	X
dpc-3965	242	4	.	.	PUNCT
dpc-3965	243	1	pmid	pmid	NOUN
dpc-3965	243	2	:	:	PUNCT
dpc-3965	243	3	 	 	SPACE
dpc-3965	243	4	35834642	35834642	NUM
dpc-3965	243	5	10	10	NUM
dpc-3965	243	6	.	.	PUNCT
dpc-3965	244	1	kumar	kumar	PROPN
dpc-3965	244	2	mh	mh	PROPN
dpc-3965	244	3	,	,	PUNCT
dpc-3965	244	4	kumar	kumar	PROPN
dpc-3965	244	5	ms	ms	PROPN
dpc-3965	244	6	,	,	PUNCT
dpc-3965	244	7	kumar	kumar	PROPN
dpc-3965	244	8	sh	sh	PROPN
dpc-3965	244	9	,	,	PUNCT
dpc-3965	244	10	kumar	kumar	PROPN
dpc-3965	244	11	ks	ks	PROPN
dpc-3965	244	12	.	.	PROPN
dpc-3965	245	1	a	a	DET
dpc-3965	245	2	neoteric	neoteric	ADJ
dpc-3965	245	3	multidrug	multidrug	NOUN
dpc-3965	245	4	combination	combination	NOUN
dpc-3965	245	5	:	:	PUNCT
dpc-3965	245	6	novel	novel	ADJ
dpc-3965	245	7	approach	approach	NOUN
dpc-3965	245	8	to	to	ADP
dpc-3965	245	9	limited	limited	ADJ
dpc-3965	245	10	cutaneous	cutaneous	ADJ
dpc-3965	245	11	systemic	systemic	ADJ
dpc-3965	245	12	scleroderma	scleroderma	NOUN
dpc-3965	245	13	involving	involve	VERB
dpc-3965	245	14	the	the	DET
dpc-3965	245	15	face	face	NOUN
dpc-3965	245	16	.	.	PUNCT
dpc-3965	246	1	bmj	bmj	PROPN
dpc-3965	246	2	case	case	NOUN
dpc-3965	246	3	rep	rep	PROPN
dpc-3965	246	4	.	.	PROPN
dpc-3965	246	5	2016;2016	2016;2016	NUM
dpc-3965	246	6	:	:	PUNCT
dpc-3965	246	7	bcr2015212787	bcr2015212787	ADJ
dpc-3965	246	8	.	.	PUNCT
dpc-3965	247	1	doi:10.1136	doi:10.1136	NOUN
dpc-3965	247	2	/	/	SYM
dpc-3965	247	3	bcr-2015	bcr-2015	NOUN
dpc-3965	247	4	-	-	PUNCT
dpc-3965	247	5	212787	212787	NUM
dpc-3965	247	6	.	.	PUNCT
dpc-3965	248	1	pmcid	pmcid	NOUN
dpc-3965	248	2	:	:	PUNCT
dpc-3965	248	3	 	 	SPACE
dpc-3965	248	4	pmc4840643	pmc4840643	VERB
dpc-3965	248	5	pmid	pmid	PROPN
dpc-3965	248	6	:	:	PUNCT
dpc-3965	248	7	 	 	SPACE
dpc-3965	248	8	27033280	27033280	NUM
dpc-3965	248	9	11	11	NUM
dpc-3965	248	10	.	.	PUNCT
dpc-3965	249	1	melvin	melvin	PROPN
dpc-3965	249	2	og	og	PROPN
dpc-3965	249	3	,	,	PUNCT
dpc-3965	249	4	hunt	hunt	NOUN
dpc-3965	249	5	km	km	PROPN
dpc-3965	249	6	,	,	PUNCT
dpc-3965	249	7	jacobson	jacobson	PROPN
dpc-3965	249	8	es	es	PROPN
dpc-3965	249	9	.	.	PROPN
dpc-3965	249	10	hyaluronidase	hyaluronidase	ADJ
dpc-3965	249	11	treatment	treatment	NOUN
dpc-3965	249	12	of	of	ADP
dpc-3965	249	13	scleroderma	scleroderma	NOUN
dpc-3965	249	14	-	-	PUNCT
dpc-3965	249	15	induced	induce	VERB
dpc-3965	249	16	microstomia	microstomia	NOUN
dpc-3965	249	17	.	.	PUNCT
dpc-3965	250	1	jama	jama	PROPN
dpc-3965	250	2	dermatol	dermatol	NOUN
dpc-3965	250	3	.	.	PUNCT
dpc-3965	251	1	2019;155(7):857	2019;155(7):857	NUM
dpc-3965	251	2	-	-	SYM
dpc-3965	251	3	859	859	NUM
dpc-3965	251	4	.	.	PUNCT
dpc-3965	252	1	doi:10.1001	doi:10.1001	PROPN
dpc-3965	252	2	/	/	SYM
dpc-3965	252	3	jamadermatol.2019.0585	jamadermatol.2019.0585	PROPN
dpc-3965	252	4	.	.	PUNCT
dpc-3965	253	1	pmid	pmid	NOUN
dpc-3965	253	2	:	:	PUNCT
dpc-3965	253	3	 	 	SPACE
dpc-3965	253	4	31141116	31141116	NUM
dpc-3965	253	5	12	12	NUM
dpc-3965	253	6	.	.	PUNCT
dpc-3965	254	1	min	min	PROPN
dpc-3965	254	2	ms	ms	PROPN
dpc-3965	254	3	,	,	PUNCT
dpc-3965	254	4	goldman	goldman	PROPN
dpc-3965	254	5	n	n	CCONJ
dpc-3965	254	6	,	,	PUNCT
dpc-3965	254	7	mazori	mazori	PROPN
dpc-3965	254	8	dr	dr	PROPN
dpc-3965	254	9	,	,	PUNCT
dpc-3965	254	10	guo	guo	PROPN
dpc-3965	254	11	ln	ln	PROPN
dpc-3965	254	12	,	,	PUNCT
dpc-3965	254	13	vleugels	vleugels	PROPN
dpc-3965	254	14	ra	ra	PROPN
dpc-3965	254	15	,	,	PUNCT
dpc-3965	254	16	lachance	lachance	PROPN
dpc-3965	254	17	ah	ah	INTJ
dpc-3965	254	18	.	.	PUNCT
dpc-3965	255	1	hyaluronidase	hyaluronidase	VERB
dpc-3965	255	2	injections	injection	NOUN
dpc-3965	255	3	for	for	ADP
dpc-3965	255	4	oral	oral	ADJ
dpc-3965	255	5	microstomia	microstomia	NOUN
dpc-3965	255	6	in	in	ADP
dpc-3965	255	7	systemic	systemic	ADJ
dpc-3965	255	8	sclerosis	sclerosis	NOUN
dpc-3965	255	9	and	and	CCONJ
dpc-3965	255	10	mixed	mixed	ADJ
dpc-3965	255	11	connective	connective	ADJ
dpc-3965	255	12	tissue	tissue	NOUN
dpc-3965	255	13	disease	disease	NOUN
dpc-3965	255	14	.	.	PUNCT
dpc-3965	256	1	jama	jama	PROPN
dpc-3965	256	2	dermatol	dermatol	NOUN
dpc-3965	256	3	.	.	PUNCT
dpc-3965	257	1	published	publish	VERB
dpc-3965	257	2	online	online	ADJ
dpc-3965	257	3	october	october	PROPN
dpc-3965	257	4	18	18	NUM
dpc-3965	257	5	,	,	PUNCT
dpc-3965	257	6	2023	2023	NUM
dpc-3965	257	7	.	.	PUNCT
dpc-3965	258	1	doi:10.1001	doi:10.1001	PROPN
dpc-3965	258	2	/	/	SYM
dpc-3965	258	3	jamadermatol	jamadermatol	PROPN
dpc-3965	258	4	.2023.3893	.2023.3893	PROPN
dpc-3965	258	5	.	.	PUNCT
dpc-3965	259	1	pmid	pmid	NOUN
dpc-3965	259	2	:	:	PUNCT
dpc-3965	259	3	 	 	SPACE
dpc-3965	259	4	37851438	37851438	NUM
dpc-3965	259	5	 	 	SPACE
dpc-3965	259	6	pmcid	pmcid	NOUN
dpc-3965	259	7	:	:	PUNCT
dpc-3965	259	8	 	 	SPACE
dpc-3965	259	9	pmc10585489	pmc10585489	NOUN
dpc-3965	259	10	13	13	NUM
dpc-3965	259	11	.	.	PUNCT
dpc-3965	260	1	chyzheuskaya	chyzheuskaya	NOUN
dpc-3965	261	1	i	i	PRON
dpc-3965	261	2	,	,	PUNCT
dpc-3965	261	3	belyaeva	belyaeva	PROPN
dpc-3965	261	4	l	l	PROPN
dpc-3965	261	5	,	,	PUNCT
dpc-3965	261	6	zajtseva	zajtseva	PROPN
dpc-3965	261	7	l	l	PROPN
dpc-3965	261	8	,	,	PUNCT
dpc-3965	261	9	khrustaleva	khrustaleva	PROPN
dpc-3965	261	10	h	h	PROPN
dpc-3965	261	11	,	,	PUNCT
dpc-3965	261	12	kolupaeva	kolupaeva	PROPN
dpc-3965	261	13	h	h	PROPN
dpc-3965	261	14	,	,	PUNCT
dpc-3965	261	15	kolomiets	kolomiet	VERB
dpc-3965	261	16	a.	a.	NOUN
dpc-3965	261	17	   	   	SPACE
dpc-3965	261	18	modern	modern	ADJ
dpc-3965	261	19	approaches	approach	NOUN
dpc-3965	261	20	to	to	ADP
dpc-3965	261	21	rehabilitation	rehabilitation	NOUN
dpc-3965	261	22	of	of	ADP
dpc-3965	261	23	children	child	NOUN
dpc-3965	261	24	with	with	ADP
dpc-3965	261	25	juvenile	juvenile	ADJ
dpc-3965	261	26	skleroderma	skleroderma	NOUN
dpc-3965	261	27	.	.	PUNCT
dpc-3965	261	28	  	  	SPACE
dpc-3965	262	1	clinical	clinical	ADJ
dpc-3965	262	2	and	and	CCONJ
dpc-3965	262	3	experimental	experimental	ADJ
dpc-3965	262	4	rheumatology	rheumatology	NOUN
dpc-3965	262	5	.	.	PUNCT
dpc-3965	263	1	2018;36,supplement	2018;36,supplement	NUM
dpc-3965	263	2	109	109	NUM
dpc-3965	263	3	(	(	PUNCT
dpc-3965	263	4	s104	s104	PROPN
dpc-3965	263	5	)	)	PUNCT
dpc-3965	263	6	.	.	PUNCT
dpc-3965	264	1	14	14	NUM
dpc-3965	264	2	.	.	PUNCT
dpc-3965	265	1	s.	s.	PROPN
dpc-3965	265	2	shahi	shahi	PROPN
dpc-3965	265	3	,	,	PUNCT
dpc-3965	265	4	s.	s.	PROPN
dpc-3965	265	5	deshpande	deshpande	PROPN
dpc-3965	265	6	.	.	PUNCT
dpc-3965	266	1	iontophoresis	iontophoresis	NOUN
dpc-3965	266	2	:	:	PUNCT
dpc-3965	266	3	an	an	DET
dpc-3965	266	4	approach	approach	NOUN
dpc-3965	266	5	to	to	ADP
dpc-3965	266	6	drug	drug	NOUN
dpc-3965	266	7	delivery	delivery	NOUN
dpc-3965	266	8	enhancement	enhancement	NOUN
dpc-3965	266	9	.	.	PUNCT
dpc-3965	267	1	int	int	PROPN
dpc-3965	267	2	j	j	PROPN
dpc-3965	267	3	pharm	pharm	PROPN
dpc-3965	267	4	sci	sci	PROPN
dpc-3965	267	5	res	res	PROPN
dpc-3965	267	6	.	.	PROPN
dpc-3965	267	7	8(10	8(10	NUM
dpc-3965	267	8	)	)	PUNCT
dpc-3965	267	9	.	.	PUNCT
dpc-3965	268	1	15	15	X
dpc-3965	268	2	.	.	X
dpc-3965	268	3	popkin	popkin	PROPN
dpc-3965	268	4	rj	rj	PROPN
dpc-3965	268	5	.	.	PUNCT
dpc-3965	269	1	the	the	DET
dpc-3965	269	2	use	use	NOUN
dpc-3965	269	3	of	of	ADP
dpc-3965	269	4	hyaluronidase	hyaluronidase	NOUN
dpc-3965	269	5	by	by	ADP
dpc-3965	269	6	iontophoresis	iontophoresis	NOUN
dpc-3965	269	7	in	in	ADP
dpc-3965	269	8	the	the	DET
dpc-3965	269	9	treatment	treatment	NOUN
dpc-3965	269	10	of	of	ADP
dpc-3965	269	11	generalized	generalized	ADJ
dpc-3965	269	12	scleroderma	scleroderma	NOUN
dpc-3965	269	13	.	.	PUNCT
dpc-3965	270	1	j	j	PROPN
dpc-3965	270	2	invest	invest	VERB
dpc-3965	270	3	dermatol	dermatol	NOUN
dpc-3965	270	4	.	.	PUNCT
dpc-3965	271	1	1951;16(2):97	1951;16(2):97	NUM
dpc-3965	271	2	-	-	SYM
dpc-3965	271	3	102	102	NUM
dpc-3965	271	4	.	.	PUNCT
dpc-3965	272	1	doi:10.1038	doi:10.1038	NOUN
dpc-3965	272	2	/	/	SYM
dpc-3965	272	3	jid.1951.15	jid.1951.15	NOUN
dpc-3965	272	4	.	.	PUNCT
dpc-3965	273	1	pmid	pmid	PROPN
dpc-3965	273	2	:	:	PUNCT
dpc-3965	273	3	 	 	SPACE
dpc-3965	273	4	14814336	14814336	NUM
dpc-3965	273	5	modality	modality	NOUN
dpc-3965	273	6	for	for	ADP
dpc-3965	273	7	a	a	DET
dpc-3965	273	8	product	product	NOUN
dpc-3965	273	9	that	that	PRON
dpc-3965	273	10	has	have	AUX
dpc-3965	273	11	become	become	VERB
dpc-3965	273	12	increasingly	increasingly	ADV
dpc-3965	273	13	cheap	cheap	ADJ
dpc-3965	273	14	and	and	CCONJ
dpc-3965	273	15	available	available	ADJ
dpc-3965	273	16	.	.	PUNCT
dpc-3965	274	1	beyond	beyond	ADP
dpc-3965	274	2	case	case	NOUN
dpc-3965	274	3	reports	report	NOUN
dpc-3965	274	4	,	,	PUNCT
dpc-3965	274	5	well	well	ADV
dpc-3965	274	6	-	-	PUNCT
dpc-3965	274	7	designed	design	VERB
dpc-3965	274	8	clinical	clinical	ADJ
dpc-3965	274	9	trials	trial	NOUN
dpc-3965	274	10	are	be	AUX
dpc-3965	274	11	necessary	necessary	ADJ
dpc-3965	274	12	and	and	CCONJ
dpc-3965	274	13	should	should	AUX
dpc-3965	274	14	be	be	AUX
dpc-3965	274	15	pursued	pursue	VERB
dpc-3965	274	16	to	to	PART
dpc-3965	274	17	establish	establish	VERB
dpc-3965	274	18	the	the	DET
dpc-3965	274	19	safety	safety	NOUN
dpc-3965	274	20	,	,	PUNCT
dpc-3965	274	21	efficacy	efficacy	NOUN
dpc-3965	274	22	,	,	PUNCT
dpc-3965	274	23	and	and	CCONJ
dpc-3965	274	24	long	long	ADJ
dpc-3965	274	25	-	-	PUNCT
dpc-3965	274	26	term	term	NOUN
dpc-3965	274	27	outcomes	outcome	NOUN
dpc-3965	274	28	of	of	ADP
dpc-3965	274	29	hyaluronidase	hyaluronidase	NOUN
dpc-3965	274	30	treatment	treatment	NOUN
dpc-3965	274	31	in	in	ADP
dpc-3965	274	32	larger	large	ADJ
dpc-3965	274	33	ssc	ssc	NOUN
dpc-3965	274	34	patient	patient	NOUN
dpc-3965	274	35	populations	population	NOUN
dpc-3965	274	36	.	.	PUNCT
dpc-3965	275	1	an	an	DET
dpc-3965	275	2	important	important	ADJ
dpc-3965	275	3	consideration	consideration	NOUN
dpc-3965	275	4	to	to	ADP
dpc-3965	275	5	advancing	advance	VERB
dpc-3965	275	6	this	this	DET
dpc-3965	275	7	therapeutic	therapeutic	ADJ
dpc-3965	275	8	option	option	NOUN
dpc-3965	275	9	is	be	AUX
dpc-3965	275	10	standardization	standardization	NOUN
dpc-3965	275	11	of	of	ADP
dpc-3965	275	12	outcome	outcome	NOUN
dpc-3965	275	13	measurements	measurement	NOUN
dpc-3965	275	14	and	and	CCONJ
dpc-3965	275	15	initiation	initiation	NOUN
dpc-3965	275	16	of	of	ADP
dpc-3965	275	17	randomized	randomized	ADJ
dpc-3965	275	18	control	control	NOUN
dpc-3965	275	19	trials	trial	NOUN
dpc-3965	275	20	(	(	PUNCT
dpc-3965	275	21	rcts	rct	NOUN
dpc-3965	275	22	)	)	PUNCT
dpc-3965	275	23	for	for	ADP
dpc-3965	275	24	high	high	ADJ
dpc-3965	275	25	-	-	PUNCT
dpc-3965	275	26	quality	quality	NOUN
dpc-3965	275	27	evidence	evidence	NOUN
dpc-3965	275	28	.	.	PUNCT
dpc-3965	276	1	the	the	DET
dpc-3965	276	2	protocol	protocol	NOUN
dpc-3965	276	3	initiated	initiate	VERB
dpc-3965	276	4	by	by	ADP
dpc-3965	276	5	min	min	PROPN
dpc-3965	276	6	et	et	PROPN
dpc-3965	276	7	al	al	PROPN
dpc-3965	276	8	.	.	PROPN
dpc-3965	276	9	provides	provide	VERB
dpc-3965	276	10	two	two	NUM
dpc-3965	276	11	objective	objective	ADJ
dpc-3965	276	12	measurements	measurement	NOUN
dpc-3965	276	13	that	that	PRON
dpc-3965	276	14	clinicians	clinician	NOUN
dpc-3965	276	15	can	can	AUX
dpc-3965	276	16	use	use	VERB
dpc-3965	276	17	in	in	ADP
dpc-3965	276	18	future	future	ADJ
dpc-3965	276	19	trials	trial	NOUN
dpc-3965	276	20	:	:	PUNCT
dpc-3965	276	21	moc	moc	NOUN
dpc-3965	276	22	and	and	CCONJ
dpc-3965	276	23	mhiss	mhiss	ADJ
dpc-3965	276	24	.	.	PUNCT
dpc-3965	277	1	durometry	durometry	NOUN
dpc-3965	277	2	or	or	CCONJ
dpc-3965	277	3	ultrasound	ultrasound	NOUN
dpc-3965	277	4	to	to	PART
dpc-3965	277	5	measure	measure	VERB
dpc-3965	277	6	skin	skin	NOUN
dpc-3965	277	7	thickness	thickness	NOUN
dpc-3965	277	8	can	can	AUX
dpc-3965	277	9	be	be	AUX
dpc-3965	277	10	considered	consider	VERB
dpc-3965	277	11	as	as	ADP
dpc-3965	277	12	an	an	DET
dpc-3965	277	13	additional	additional	ADJ
dpc-3965	277	14	outcome	outcome	NOUN
dpc-3965	277	15	measurement	measurement	NOUN
dpc-3965	277	16	for	for	ADP
dpc-3965	277	17	hylauronidase	hylauronidase	NOUN
dpc-3965	277	18	in	in	ADP
dpc-3965	277	19	ssc	ssc	PROPN
dpc-3965	277	20	.	.	PUNCT
dpc-3965	278	1	an	an	DET
dpc-3965	278	2	rct	rct	PROPN
dpc-3965	278	3	for	for	ADP
dpc-3965	278	4	hyalornidase	hyalornidase	PROPN
dpc-3965	278	5	in	in	ADP
dpc-3965	278	6	ssc	ssc	NOUN
dpc-3965	278	7	microstomia	microstomia	NOUN
dpc-3965	278	8	could	could	AUX
dpc-3965	278	9	involve	involve	VERB
dpc-3965	278	10	placebo	placebo	NOUN
dpc-3965	278	11	injections	injection	NOUN
dpc-3965	278	12	versus	versus	ADP
dpc-3965	278	13	hylaronidase	hylaronidase	NOUN
dpc-3965	278	14	over	over	ADP
dpc-3965	278	15	1	1	NUM
dpc-3965	278	16	year	year	NOUN
dpc-3965	278	17	,	,	PUNCT
dpc-3965	278	18	a	a	DET
dpc-3965	278	19	longer	long	ADJ
dpc-3965	278	20	time	time	NOUN
dpc-3965	278	21	course	course	ADV
dpc-3965	278	22	than	than	ADP
dpc-3965	278	23	most	most	ADJ
dpc-3965	278	24	of	of	ADP
dpc-3965	278	25	the	the	DET
dpc-3965	278	26	studies	study	NOUN
dpc-3965	278	27	mentioned	mention	VERB
dpc-3965	278	28	in	in	ADP
dpc-3965	278	29	this	this	DET
dpc-3965	278	30	review	review	NOUN
dpc-3965	278	31	.	.	PUNCT
dpc-3965	279	1	a	a	DET
dpc-3965	279	2	longer	long	ADJ
dpc-3965	279	3	time	time	NOUN
dpc-3965	279	4	course	course	NOUN
dpc-3965	279	5	will	will	AUX
dpc-3965	279	6	allow	allow	VERB
dpc-3965	279	7	better	well	ADJ
dpc-3965	279	8	observation	observation	NOUN
dpc-3965	279	9	of	of	ADP
dpc-3965	279	10	any	any	DET
dpc-3965	279	11	plateau	plateau	NOUN
dpc-3965	279	12	or	or	CCONJ
dpc-3965	279	13	adverse	adverse	ADJ
dpc-3965	279	14	effect	effect	NOUN
dpc-3965	279	15	of	of	ADP
dpc-3965	279	16	hylauronidase	hylauronidase	NOUN
dpc-3965	279	17	outside	outside	ADV
dpc-3965	279	18	of	of	ADP
dpc-3965	279	19	the	the	DET
dpc-3965	279	20	treatment	treatment	NOUN
dpc-3965	279	21	period	period	NOUN
dpc-3965	279	22	.	.	PUNCT
dpc-3965	280	1	all	all	ADV
dpc-3965	280	2	in	in	ADP
dpc-3965	280	3	all	all	PRON
dpc-3965	280	4	,	,	PUNCT
dpc-3965	280	5	a	a	DET
dpc-3965	280	6	multidisciplinary	multidisciplinary	ADJ
dpc-3965	280	7	approach	approach	NOUN
dpc-3965	280	8	involving	involve	VERB
dpc-3965	280	9	collaboration	collaboration	NOUN
dpc-3965	280	10	among	among	ADP
dpc-3965	280	11	various	various	ADJ
dpc-3965	280	12	specialists	specialist	NOUN
dpc-3965	280	13	,	,	PUNCT
dpc-3965	280	14	including	include	VERB
dpc-3965	280	15	dermatologists	dermatologist	NOUN
dpc-3965	280	16	and	and	CCONJ
dpc-3965	280	17	rheumatologists	rheumatologist	NOUN
dpc-3965	280	18	is	be	AUX
dpc-3965	280	19	imperative	imperative	ADJ
dpc-3965	280	20	when	when	SCONJ
dpc-3965	280	21	considering	consider	VERB
dpc-3965	280	22	this	this	DET
dpc-3965	280	23	approach	approach	NOUN
dpc-3965	280	24	to	to	ADP
dpc-3965	280	25	ssc	ssc	NOUN
dpc-3965	280	26	symptom	symptom	NOUN
dpc-3965	280	27	management	management	NOUN
dpc-3965	280	28	.	.	PUNCT
dpc-3965	281	1	moreover	moreover	ADV
dpc-3965	281	2	,	,	PUNCT
dpc-3965	281	3	it	it	PRON
dpc-3965	281	4	is	be	AUX
dpc-3965	281	5	essential	essential	ADJ
dpc-3965	281	6	to	to	PART
dpc-3965	281	7	acknowledge	acknowledge	VERB
dpc-3965	281	8	the	the	DET
dpc-3965	281	9	limited	limited	ADJ
dpc-3965	281	10	scope	scope	NOUN
dpc-3965	281	11	of	of	ADP
dpc-3965	281	12	the	the	DET
dpc-3965	281	13	case	case	NOUN
dpc-3965	281	14	reports	report	NOUN
dpc-3965	281	15	discussed	discuss	VERB
dpc-3965	281	16	,	,	PUNCT
dpc-3965	281	17	highlighting	highlight	VERB
dpc-3965	281	18	the	the	DET
dpc-3965	281	19	need	need	NOUN
dpc-3965	281	20	for	for	ADP
dpc-3965	281	21	standardized	standardized	ADJ
dpc-3965	281	22	,	,	PUNCT
dpc-3965	281	23	large	large	ADJ
dpc-3965	281	24	-	-	PUNCT
dpc-3965	281	25	scale	scale	NOUN
dpc-3965	281	26	research	research	NOUN
dpc-3965	281	27	to	to	PART
dpc-3965	281	28	establish	establish	VERB
dpc-3965	281	29	the	the	DET
dpc-3965	281	30	safety	safety	NOUN
dpc-3965	281	31	and	and	CCONJ
dpc-3965	281	32	effectiveness	effectiveness	NOUN
dpc-3965	281	33	of	of	ADP
dpc-3965	281	34	hyaluronidase	hyaluronidase	NOUN
dpc-3965	281	35	in	in	ADP
dpc-3965	281	36	these	these	DET
dpc-3965	281	37	patients	patient	NOUN
dpc-3965	281	38	.	.	PUNCT
dpc-3965	282	1	while	while	SCONJ
dpc-3965	282	2	physicians	physician	NOUN
dpc-3965	282	3	should	should	AUX
dpc-3965	282	4	adhere	adhere	VERB
dpc-3965	282	5	to	to	ADP
dpc-3965	282	6	current	current	ADJ
dpc-3965	282	7	evidence	evidence	NOUN
dpc-3965	282	8	-	-	PUNCT
dpc-3965	282	9	based	base	VERB
dpc-3965	282	10	treatment	treatment	NOUN
dpc-3965	282	11	guidelines	guideline	NOUN
dpc-3965	282	12	to	to	PART
dpc-3965	282	13	manage	manage	VERB
dpc-3965	282	14	ssc	ssc	NOUN
dpc-3965	282	15	symptoms	symptom	NOUN
dpc-3965	282	16	,	,	PUNCT
dpc-3965	282	17	it	it	PRON
dpc-3965	282	18	is	be	AUX
dpc-3965	282	19	important	important	ADJ
dpc-3965	282	20	to	to	PART
dpc-3965	282	21	be	be	AUX
dpc-3965	282	22	open	open	ADJ
dpc-3965	282	23	-	-	PUNCT
dpc-3965	282	24	minded	minded	ADJ
dpc-3965	282	25	about	about	ADP
dpc-3965	282	26	exploring	explore	VERB
dpc-3965	282	27	alternative	alternative	ADJ
dpc-3965	282	28	therapeutic	therapeutic	ADJ
dpc-3965	282	29	approaches	approach	NOUN
dpc-3965	282	30	when	when	SCONJ
dpc-3965	282	31	needed	need	VERB
dpc-3965	282	32	.	.	PUNCT
dpc-3965	283	1	conclusions	conclusion	NOUN
dpc-3965	283	2	overall	overall	ADV
dpc-3965	283	3	,	,	PUNCT
dpc-3965	283	4	the	the	DET
dpc-3965	283	5	use	use	NOUN
dpc-3965	283	6	of	of	ADP
dpc-3965	283	7	hyaluronidase	hyaluronidase	NOUN
dpc-3965	283	8	in	in	ADP
dpc-3965	283	9	ssc	ssc	PROPN
dpc-3965	283	10	is	be	AUX
dpc-3965	283	11	under	under	ADV
dpc-3965	283	12	-	-	PUNCT
dpc-3965	283	13	researched	research	VERB
dpc-3965	283	14	.	.	PUNCT
dpc-3965	284	1	case	case	NOUN
dpc-3965	284	2	reports	report	NOUN
dpc-3965	284	3	have	have	AUX
dpc-3965	284	4	shown	show	VERB
dpc-3965	284	5	hyaluronidase	hyaluronidase	ADJ
dpc-3965	284	6	efficacy	efficacy	NOUN
dpc-3965	284	7	in	in	ADP
dpc-3965	284	8	treating	treat	VERB
dpc-3965	284	9	microstomia	microstomia	NOUN
dpc-3965	284	10	in	in	ADP
dpc-3965	284	11	ssc	ssc	PROPN
dpc-3965	284	12	.	.	PUNCT
dpc-3965	285	1	however	however	ADV
dpc-3965	285	2	,	,	PUNCT
dpc-3965	285	3	limited	limited	ADJ
dpc-3965	285	4	research	research	NOUN
dpc-3965	285	5	has	have	AUX
dpc-3965	285	6	shown	show	VERB
dpc-3965	285	7	this	this	DET
dpc-3965	285	8	treatment	treatment	NOUN
dpc-3965	285	9	modality	modality	NOUN
dpc-3965	285	10	used	use	VERB
dpc-3965	285	11	in	in	ADP
dpc-3965	285	12	the	the	DET
dpc-3965	285	13	setting	setting	NOUN
dpc-3965	285	14	of	of	ADP
dpc-3965	285	15	randomized	randomized	ADJ
dpc-3965	285	16	control	control	NOUN
dpc-3965	285	17	trials	trial	NOUN
dpc-3965	285	18	,	,	PUNCT
dpc-3965	285	19	case	case	NOUN
dpc-3965	285	20	-	-	PUNCT
dpc-3965	285	21	control	control	NOUN
dpc-3965	285	22	trials	trial	NOUN
dpc-3965	285	23	,	,	PUNCT
dpc-3965	285	24	or	or	CCONJ
dpc-3965	285	25	cohort	cohort	NOUN
dpc-3965	285	26	studies	study	NOUN
dpc-3965	285	27	with	with	ADP
dpc-3965	285	28	standardized	standardized	ADJ
dpc-3965	285	29	outcome	outcome	NOUN
dpc-3965	285	30	measures	measure	NOUN
dpc-3965	285	31	.	.	PUNCT
dpc-3965	286	1	the	the	DET
dpc-3965	286	2	duration	duration	NOUN
dpc-3965	286	3	of	of	ADP
dpc-3965	286	4	symptom	symptom	NOUN
dpc-3965	286	5	improvement	improvement	NOUN
dpc-3965	286	6	and	and	CCONJ
dpc-3965	286	7	potential	potential	ADJ
dpc-3965	286	8	long	long	ADJ
dpc-3965	286	9	-	-	PUNCT
dpc-3965	286	10	term	term	NOUN
dpc-3965	286	11	effects	effect	NOUN
dpc-3965	286	12	should	should	AUX
dpc-3965	286	13	be	be	AUX
dpc-3965	286	14	further	far	ADV
dpc-3965	286	15	investigated	investigate	VERB
dpc-3965	286	16	in	in	ADP
dpc-3965	286	17	hyaluronidase	hyaluronidase	NOUN
dpc-3965	286	18	as	as	ADP
dpc-3965	286	19	a	a	DET
dpc-3965	286	20	promising	promising	ADJ
dpc-3965	286	21	therapeutic	therapeutic	ADJ
dpc-3965	286	22	option	option	NOUN
dpc-3965	286	23	for	for	ADP
dpc-3965	286	24	scleroderma	scleroderma	NOUN
dpc-3965	286	25	patients	patient	NOUN
dpc-3965	286	26	.	.	PUNCT
dpc-3965	287	1	references	reference	NOUN
dpc-3965	287	2	1	1	NUM
dpc-3965	287	3	.	.	PUNCT
dpc-3965	287	4	adigun	adigun	PROPN
dpc-3965	287	5	r	r	NOUN
dpc-3965	287	6	,	,	PUNCT
dpc-3965	287	7	goyal	goyal	PROPN
dpc-3965	287	8	a	a	X
dpc-3965	287	9	,	,	PUNCT
dpc-3965	287	10	hariz	hariz	NOUN
dpc-3965	287	11	a.	a.	NOUN
dpc-3965	287	12	systemic	systemic	ADJ
dpc-3965	287	13	sclerosis	sclerosis	NOUN
dpc-3965	287	14	.	.	PUNCT
dpc-3965	288	1	in	in	ADP
dpc-3965	288	2	:	:	PUNCT
dpc-3965	288	3	statpearls	statpearl	NOUN
dpc-3965	288	4	.	.	PUNCT
dpc-3965	289	1	statpearls	statpearl	NOUN
dpc-3965	289	2	publishing	publishing	NOUN
dpc-3965	289	3	;	;	PUNCT
dpc-3965	289	4	2023	2023	NUM
dpc-3965	289	5	.	.	PUNCT
dpc-3965	290	1	accessed	access	VERB
dpc-3965	290	2	october	october	PROPN
dpc-3965	290	3	22	22	NUM
dpc-3965	290	4	,	,	PUNCT
dpc-3965	290	5	2023	2023	NUM
dpc-3965	290	6	.	.	PUNCT
dpc-3965	291	1	http://	http://	PROPN
dpc-3965	291	2	www.ncbi.nlm.nih.gov/books/nbk430875/	www.ncbi.nlm.nih.gov/books/nbk430875/	NOUN
dpc-3965	291	3	adigun	adigun	VERB
dpc-3965	291	4	r	r	NOUN
dpc-3965	291	5	,	,	PUNCT
dpc-3965	291	6	goyal	goyal	PROPN
dpc-3965	291	7	a	a	X
dpc-3965	291	8	,	,	PUNCT
dpc-3965	291	9	hariz	hariz	NOUN
dpc-3965	291	10	a.	a.	NOUN
dpc-3965	291	11	systemic	systemic	ADJ
dpc-3965	291	12	sclerosis	sclerosis	NOUN
dpc-3965	291	13	(	(	PUNCT
dpc-3965	291	14	scleroderma	scleroderma	NOUN
dpc-3965	291	15	)	)	PUNCT
dpc-3965	291	16	.	.	PUNCT
dpc-3965	292	1	2024	2024	NUM
dpc-3965	292	2	in	in	ADP
dpc-3965	292	3	:	:	PUNCT
dpc-3965	292	4	statpearls	statpearl	NOUN
dpc-3965	293	1	[	[	X
dpc-3965	293	2	internet	internet	NOUN
dpc-3965	293	3	]	]	PUNCT
dpc-3965	293	4	.	.	PUNCT
dpc-3965	294	1	treasure	treasure	NOUN
dpc-3965	294	2	island	island	NOUN
dpc-3965	294	3	(	(	PUNCT
dpc-3965	294	4	fl	fl	PROPN
dpc-3965	294	5	):	):	PUNCT
dpc-3965	294	6	statpearls	statpearl	NOUN
dpc-3965	294	7	publishing	publishing	NOUN
dpc-3965	294	8	;	;	PUNCT
dpc-3965	294	9	2024	2024	NUM
dpc-3965	294	10	jan–.	jan–.	PUNCT
dpc-3965	295	1	pmid	pmid	NOUN
dpc-3965	295	2	:	:	PUNCT
dpc-3965	295	3	28613625	28613625	NUM
dpc-3965	295	4	.	.	PUNCT
dpc-3965	295	5	8	8	NUM
dpc-3965	295	6	review	review	NOUN
dpc-3965	295	7	|	|	ADV
dpc-3965	295	8	dermatol	dermatol	ADJ
dpc-3965	295	9	pract	pract	NOUN
dpc-3965	295	10	concept	concept	NOUN
dpc-3965	295	11	.	.	PUNCT
dpc-3965	296	1	2024;14(3):e2024163	2024;14(3):e2024163	NUM
dpc-3965	296	2	20	20	NUM
dpc-3965	296	3	.	.	PUNCT
dpc-3965	297	1	lee	lee	PROPN
dpc-3965	297	2	a	a	PRON
dpc-3965	297	3	,	,	PUNCT
dpc-3965	297	4	grummer	grummer	NOUN
dpc-3965	297	5	se	se	PROPN
dpc-3965	297	6	,	,	PUNCT
dpc-3965	297	7	kriegel	kriegel	PROPN
dpc-3965	297	8	d	d	PROPN
dpc-3965	297	9	,	,	PUNCT
dpc-3965	297	10	marmur	marmur	ADJ
dpc-3965	297	11	e.	e.	PROPN
dpc-3965	297	12	hyaluronidase	hyaluronidase	PROPN
dpc-3965	297	13	.	.	PUNCT
dpc-3965	298	1	dermatol	dermatol	NOUN
dpc-3965	298	2	surg	surg	NOUN
dpc-3965	298	3	off	off	ADP
dpc-3965	298	4	publ	publ	NOUN
dpc-3965	298	5	am	be	AUX
dpc-3965	298	6	soc	soc	NOUN
dpc-3965	298	7	dermatol	dermatol	NOUN
dpc-3965	298	8	surg	surg	PROPN
dpc-3965	298	9	al	al	PROPN
dpc-3965	298	10	.	.	PROPN
dpc-3965	299	1	2010;36(7	2010;36(7	NUM
dpc-3965	299	2	):	):	PUNCT
dpc-3965	299	3	1071	1071	NUM
dpc-3965	299	4	-	-	SYM
dpc-3965	299	5	1077	1077	NUM
dpc-3965	299	6	.	.	PUNCT
dpc-3965	300	1	doi:10.1111	doi:10.1111	PROPN
dpc-3965	300	2	/	/	SYM
dpc-3965	300	3	j.1524	j.1524	NOUN
dpc-3965	300	4	-	-	PUNCT
dpc-3965	300	5	4725.2010.01585.x	4725.2010.01585.x	NUM
dpc-3965	300	6	21	21	NUM
dpc-3965	300	7	.	.	PUNCT
dpc-3965	300	8	hu	hu	PROPN
dpc-3965	301	1	w	w	PROPN
dpc-3965	301	2	,	,	PUNCT
dpc-3965	301	3	peng	peng	PROPN
dpc-3965	301	4	t	t	PROPN
dpc-3965	301	5	,	,	PUNCT
dpc-3965	301	6	huang	huang	PROPN
dpc-3965	301	7	y	y	PROPN
dpc-3965	301	8	,	,	PUNCT
dpc-3965	301	9	et	et	PROPN
dpc-3965	301	10	al	al	PROPN
dpc-3965	301	11	.	.	PUNCT
dpc-3965	301	12	hyaluronidase	hyaluronidase	NOUN
dpc-3965	301	13	-	-	PUNCT
dpc-3965	301	14	powered	power	VERB
dpc-3965	301	15	microneedles	microneedle	NOUN
dpc-3965	301	16	for	for	ADP
dpc-3965	301	17	significantly	significantly	ADV
dpc-3965	301	18	enhanced	enhance	VERB
dpc-3965	301	19	transdermal	transdermal	ADJ
dpc-3965	301	20	delivery	delivery	NOUN
dpc-3965	301	21	efficiency	efficiency	NOUN
dpc-3965	301	22	.	.	PUNCT
dpc-3965	302	1	j	j	PROPN
dpc-3965	302	2	control	control	PROPN
dpc-3965	302	3	release	release	VERB
dpc-3965	302	4	off	off	ADP
dpc-3965	302	5	j	j	PROPN
dpc-3965	302	6	control	control	PROPN
dpc-3965	302	7	release	release	PROPN
dpc-3965	302	8	soc	soc	NOUN
dpc-3965	302	9	.	.	PUNCT
dpc-3965	303	1	2023;353:380	2023;353:380	NUM
dpc-3965	303	2	-	-	SYM
dpc-3965	303	3	390	390	NUM
dpc-3965	303	4	.	.	PUNCT
dpc-3965	303	5	doi:10.1016	doi:10.1016	PROPN
dpc-3965	303	6	/	/	SYM
dpc-3965	303	7	j.jconrel.2022.11.046	j.jconrel.2022.11.046	PROPN
dpc-3965	303	8	.	.	PUNCT
dpc-3965	304	1	pmid	pmid	NOUN
dpc-3965	304	2	:	:	PUNCT
dpc-3965	304	3	 	 	SPACE
dpc-3965	304	4	36464062	36464062	NUM
dpc-3965	304	5	22	22	NUM
dpc-3965	304	6	.	.	PUNCT
dpc-3965	305	1	fronza	fronza	PROPN
dpc-3965	305	2	m	m	PROPN
dpc-3965	305	3	,	,	PUNCT
dpc-3965	305	4	caetano	caetano	PROPN
dpc-3965	305	5	gf	gf	PROPN
dpc-3965	305	6	,	,	PUNCT
dpc-3965	305	7	leite	leite	PROPN
dpc-3965	305	8	mn	mn	PROPN
dpc-3965	305	9	,	,	PUNCT
dpc-3965	305	10	et	et	PROPN
dpc-3965	305	11	al	al	PROPN
dpc-3965	305	12	.	.	PUNCT
dpc-3965	306	1	hyaluronidase	hyaluronidase	PROPN
dpc-3965	306	2	modulates	modulate	VERB
dpc-3965	306	3	inflammatory	inflammatory	ADJ
dpc-3965	306	4	response	response	NOUN
dpc-3965	306	5	and	and	CCONJ
dpc-3965	306	6	accelerates	accelerate	VERB
dpc-3965	306	7	the	the	DET
dpc-3965	306	8	cutaneous	cutaneous	ADJ
dpc-3965	306	9	wound	wound	NOUN
dpc-3965	306	10	healing	healing	NOUN
dpc-3965	306	11	.	.	PUNCT
dpc-3965	307	1	plos	plos	PROPN
dpc-3965	307	2	one	one	NUM
dpc-3965	307	3	.	.	PUNCT
dpc-3965	308	1	2014;9(11):e112297	2014;9(11):e112297	PROPN
dpc-3965	308	2	.	.	PUNCT
dpc-3965	308	3	doi:10.1371	doi:10.1371	PROPN
dpc-3965	308	4	/	/	SYM
dpc-3965	308	5	journal	journal	NOUN
dpc-3965	308	6	.	.	PUNCT
dpc-3965	309	1	pone.0112297	pone.0112297	PROPN
dpc-3965	309	2	.	.	PUNCT
dpc-3965	310	1	pmid	pmid	PROPN
dpc-3965	310	2	:	:	PUNCT
dpc-3965	310	3	 	 	SPACE
dpc-3965	310	4	25393024	25393024	NUM
dpc-3965	310	5	 	 	SPACE
dpc-3965	310	6	pmcid	pmcid	NOUN
dpc-3965	310	7	:	:	PUNCT
dpc-3965	310	8	 	 	SPACE
dpc-3965	310	9	pmc4230982	pmc4230982	VERB
dpc-3965	310	10	16	16	NUM
dpc-3965	310	11	.	.	PUNCT
dpc-3965	311	1	bissell	bissell	PROPN
dpc-3965	311	2	mj	mj	PROPN
dpc-3965	311	3	,	,	PUNCT
dpc-3965	311	4	hall	hall	PROPN
dpc-3965	311	5	hg	hg	PROPN
dpc-3965	311	6	,	,	PUNCT
dpc-3965	311	7	parry	parry	PROPN
dpc-3965	311	8	g.	g.	PROPN
dpc-3965	312	1	how	how	SCONJ
dpc-3965	312	2	does	do	AUX
dpc-3965	312	3	the	the	DET
dpc-3965	312	4	extracellular	extracellular	ADJ
dpc-3965	312	5	matrix	matrix	NOUN
dpc-3965	312	6	direct	direct	ADJ
dpc-3965	312	7	gene	gene	NOUN
dpc-3965	312	8	expression	expression	NOUN
dpc-3965	312	9	?	?	PUNCT
dpc-3965	313	1	j	j	PROPN
dpc-3965	313	2	theor	theor	PROPN
dpc-3965	313	3	biol	biol	PROPN
dpc-3965	313	4	.	.	PUNCT
dpc-3965	314	1	1982;99(1):31	1982;99(1):31	NUM
dpc-3965	314	2	-	-	SYM
dpc-3965	314	3	68	68	NUM
dpc-3965	314	4	.	.	PUNCT
dpc-3965	314	5	doi:10.1016/0022	doi:10.1016/0022	NOUN
dpc-3965	314	6	-	-	PUNCT
dpc-3965	314	7	5193(82)90388	5193(82)90388	NUM
dpc-3965	314	8	-	-	SYM
dpc-3965	314	9	5	5	NUM
dpc-3965	314	10	17	17	NUM
dpc-3965	314	11	.	.	PUNCT
dpc-3965	315	1	laurent	laurent	PROPN
dpc-3965	315	2	tc	tc	PROPN
dpc-3965	315	3	,	,	PUNCT
dpc-3965	315	4	fraser	fraser	PROPN
dpc-3965	315	5	jr	jr	PROPN
dpc-3965	315	6	.	.	PROPN
dpc-3965	315	7	hyaluronan	hyaluronan	PROPN
dpc-3965	315	8	.	.	PUNCT
dpc-3965	316	1	faseb	faseb	PROPN
dpc-3965	316	2	j	j	PROPN
dpc-3965	316	3	off	off	ADP
dpc-3965	316	4	publ	publ	NOUN
dpc-3965	316	5	fed	fed	PROPN
dpc-3965	316	6	am	be	AUX
dpc-3965	316	7	soc	soc	NOUN
dpc-3965	316	8	exp	exp	NOUN
dpc-3965	316	9	biol	biol	NOUN
dpc-3965	316	10	.	.	PUNCT
dpc-3965	317	1	1992;6(7):2397	1992;6(7):2397	NUM
dpc-3965	317	2	-	-	SYM
dpc-3965	317	3	2404	2404	NUM
dpc-3965	317	4	.	.	PUNCT
dpc-3965	318	1	pmid	pmid	NOUN
dpc-3965	318	2	:	:	PUNCT
dpc-3965	318	3	 	 	SPACE
dpc-3965	318	4	1563592	1563592	NUM
dpc-3965	318	5	18	18	NUM
dpc-3965	318	6	.	.	PUNCT
dpc-3965	319	1	buhren	buhren	PROPN
dpc-3965	319	2	ba	ba	PROPN
dpc-3965	319	3	,	,	PUNCT
dpc-3965	319	4	schrumpf	schrumpf	VERB
dpc-3965	319	5	h	h	PROPN
dpc-3965	319	6	,	,	PUNCT
dpc-3965	319	7	hoff	hoff	PROPN
dpc-3965	319	8	np	np	PROPN
dpc-3965	319	9	,	,	PUNCT
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dpc-3965	319	11	e	e	NOUN
dpc-3965	319	12	,	,	PUNCT
dpc-3965	319	13	hilton	hilton	PROPN
dpc-3965	319	14	s	s	PROPN
dpc-3965	319	15	,	,	PUNCT
dpc-3965	319	16	gerber	gerber	PROPN
dpc-3965	319	17	pa	pa	PROPN
dpc-3965	320	1	.	.	PROPN
dpc-3965	320	2	hyaluronidase	hyaluronidase	PROPN
dpc-3965	320	3	:	:	PUNCT
dpc-3965	320	4	from	from	ADP
dpc-3965	320	5	clinical	clinical	ADJ
dpc-3965	320	6	applications	application	NOUN
dpc-3965	320	7	to	to	ADP
dpc-3965	320	8	molecular	molecular	ADJ
dpc-3965	320	9	and	and	CCONJ
dpc-3965	320	10	cellular	cellular	ADJ
dpc-3965	320	11	mechanisms	mechanism	NOUN
dpc-3965	320	12	.	.	PUNCT
dpc-3965	321	1	eur	eur	PROPN
dpc-3965	321	2	j	j	PROPN
dpc-3965	321	3	med	med	PROPN
dpc-3965	321	4	res	re	NOUN
dpc-3965	321	5	.	.	PUNCT
dpc-3965	322	1	2016;21:5	2016;21:5	NUM
dpc-3965	322	2	.	.	PROPN
dpc-3965	322	3	doi:10.1186	doi:10.1186	VERB
dpc-3965	322	4	/s40001	/s40001	X
dpc-3965	322	5	-	-	PUNCT
dpc-3965	322	6	016	016	NUM
dpc-3965	322	7	-	-	PUNCT
dpc-3965	322	8	0201	0201	NUM
dpc-3965	322	9	-	-	SYM
dpc-3965	322	10	5	5	NUM
dpc-3965	322	11	.	.	PUNCT
dpc-3965	323	1	pmid	pmid	NOUN
dpc-3965	323	2	:	:	PUNCT
dpc-3965	323	3	 	 	SPACE
dpc-3965	323	4	26873038	26873038	NUM
dpc-3965	323	5	 	 	SPACE
dpc-3965	323	6	pmcid	pmcid	NOUN
dpc-3965	323	7	:	:	PUNCT
dpc-3965	323	8	 	 	SPACE
dpc-3965	323	9	pmc4752759	pmc4752759	ADV
dpc-3965	323	10	19	19	NUM
dpc-3965	323	11	.	.	PUNCT
dpc-3965	324	1	neudecker	neudecker	PROPN
dpc-3965	324	2	ba	ba	PROPN
dpc-3965	324	3	,	,	PUNCT
dpc-3965	324	4	stern	stern	ADJ
dpc-3965	324	5	r	r	PROPN
dpc-3965	324	6	,	,	PUNCT
dpc-3965	324	7	connolly	connolly	PROPN
dpc-3965	324	8	mk	mk	PROPN
dpc-3965	324	9	.	.	PUNCT
dpc-3965	324	10	aberrant	aberrant	PROPN
dpc-3965	324	11	serum	serum	PROPN
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dpc-3965	324	14	hyaluronidase	hyaluronidase	ADJ
dpc-3965	324	15	levels	level	NOUN
dpc-3965	324	16	in	in	ADP
dpc-3965	324	17	scleroderma	scleroderma	NOUN
dpc-3965	324	18	.	.	PUNCT
dpc-3965	325	1	br	br	PROPN
dpc-3965	325	2	j	j	PROPN
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dpc-3965	325	4	.	.	PUNCT
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dpc-3965	326	2	-	-	SYM
dpc-3965	326	3	476	476	NUM
dpc-3965	326	4	.	.	PUNCT
dpc-3965	327	1	doi:10.1046	doi:10.1046	ADJ
dpc-3965	327	2	/	/	SYM
dpc-3965	327	3	j.1365	j.1365	NOUN
dpc-3965	327	4	-	-	PUNCT
dpc-3965	327	5	2133.2004.05805.x	2133.2004.05805.x	NUM
dpc-3965	327	6	.	.	PUNCT
dpc-3965	328	1	pmid	pmid	NOUN
dpc-3965	328	2	:	:	PUNCT
dpc-3965	328	3	 	 	SPACE
dpc-3965	328	4	15030329	15030329	NUM