id	sid	tid	token	lemma	pos
dpc-4148	1	1	dermatology	dermatology	NOUN
dpc-4148	1	2	:	:	PUNCT
dpc-4148	1	3	practical	practical	ADJ
dpc-4148	1	4	and	and	CCONJ
dpc-4148	1	5	conceptual	conceptual	ADJ
dpc-4148	1	6	original	original	ADJ
dpc-4148	1	7	article	article	NOUN
dpc-4148	1	8	|	|	ADV
dpc-4148	1	9	dermatol	dermatol	ADJ
dpc-4148	1	10	pract	pract	NOUN
dpc-4148	1	11	concept	concept	NOUN
dpc-4148	1	12	.	.	PUNCT
dpc-4148	2	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	2	2	1	1	NUM
dpc-4148	2	3	profiling	profiling	NOUN
dpc-4148	2	4	of	of	ADP
dpc-4148	2	5	toll	toll	NOUN
dpc-4148	2	6	-	-	PUNCT
dpc-4148	2	7	like	like	ADJ
dpc-4148	2	8	receptors	receptor	NOUN
dpc-4148	2	9	and	and	CCONJ
dpc-4148	2	10	related	relate	VERB
dpc-4148	2	11	signaling	signal	VERB
dpc-4148	2	12	mediators	mediator	NOUN
dpc-4148	2	13	in	in	ADP
dpc-4148	2	14	the	the	DET
dpc-4148	2	15	pathogenesis	pathogenesis	NOUN
dpc-4148	2	16	of	of	ADP
dpc-4148	2	17	morphea	morphea	PROPN
dpc-4148	2	18	hilal	hilal	PROPN
dpc-4148	2	19	ayvaz	ayvaz	PROPN
dpc-4148	2	20	celik1	celik1	PROPN
dpc-4148	2	21	,	,	PUNCT
dpc-4148	2	22	nilgun	nilgun	PROPN
dpc-4148	2	23	gurbuz2	gurbuz2	NOUN
dpc-4148	2	24	,	,	PUNCT
dpc-4148	2	25	ergin	ergin	NOUN
dpc-4148	2	26	turantepe2	turantepe2	PROPN
dpc-4148	2	27	,	,	PUNCT
dpc-4148	2	28	mücahit	mücahit	PROPN
dpc-4148	2	29	secme3	secme3	PROPN
dpc-4148	2	30	,	,	PUNCT
dpc-4148	2	31	yavuz	yavuz	PROPN
dpc-4148	2	32	dodurga4	dodurga4	PROPN
dpc-4148	2	33	1	1	NUM
dpc-4148	2	34	department	department	NOUN
dpc-4148	2	35	of	of	ADP
dpc-4148	2	36	dermatology	dermatology	NOUN
dpc-4148	2	37	,	,	PUNCT
dpc-4148	2	38	faculty	faculty	NOUN
dpc-4148	2	39	of	of	ADP
dpc-4148	2	40	medicine	medicine	NOUN
dpc-4148	2	41	,	,	PUNCT
dpc-4148	2	42	suleyman	suleyman	NOUN
dpc-4148	2	43	demirel	demirel	NOUN
dpc-4148	2	44	university	university	NOUN
dpc-4148	2	45	,	,	PUNCT
dpc-4148	2	46	isparta	isparta	PROPN
dpc-4148	2	47	,	,	PUNCT
dpc-4148	2	48	türkiye	türkiye	PROPN
dpc-4148	2	49	2	2	NUM
dpc-4148	2	50	department	department	NOUN
dpc-4148	2	51	of	of	ADP
dpc-4148	2	52	medical	medical	ADJ
dpc-4148	2	53	biology	biology	NOUN
dpc-4148	2	54	,	,	PUNCT
dpc-4148	2	55	faculty	faculty	NOUN
dpc-4148	2	56	of	of	ADP
dpc-4148	2	57	medicine	medicine	NOUN
dpc-4148	2	58	,	,	PUNCT
dpc-4148	2	59	suleyman	suleyman	NOUN
dpc-4148	2	60	demirel	demirel	NOUN
dpc-4148	2	61	university	university	NOUN
dpc-4148	2	62	,	,	PUNCT
dpc-4148	2	63	isparta	isparta	PROPN
dpc-4148	2	64	,	,	PUNCT
dpc-4148	2	65	türkiye	türkiye	PROPN
dpc-4148	2	66	3	3	NUM
dpc-4148	2	67	department	department	PROPN
dpc-4148	2	68	of	of	ADP
dpc-4148	2	69	medical	medical	ADJ
dpc-4148	2	70	biology	biology	NOUN
dpc-4148	2	71	,	,	PUNCT
dpc-4148	2	72	faculty	faculty	NOUN
dpc-4148	2	73	of	of	ADP
dpc-4148	2	74	medicine	medicine	NOUN
dpc-4148	2	75	,	,	PUNCT
dpc-4148	2	76	ordu	ordu	PROPN
dpc-4148	2	77	university	university	PROPN
dpc-4148	2	78	,	,	PUNCT
dpc-4148	2	79	ordu	ordu	PROPN
dpc-4148	2	80	,	,	PUNCT
dpc-4148	2	81	türkiye	türkiye	PROPN
dpc-4148	2	82	4	4	NUM
dpc-4148	2	83	department	department	NOUN
dpc-4148	2	84	of	of	ADP
dpc-4148	2	85	medical	medical	ADJ
dpc-4148	2	86	biology	biology	NOUN
dpc-4148	2	87	,	,	PUNCT
dpc-4148	2	88	faculty	faculty	NOUN
dpc-4148	2	89	of	of	ADP
dpc-4148	2	90	medicine	medicine	NOUN
dpc-4148	2	91	,	,	PUNCT
dpc-4148	2	92	pamukkale	pamukkale	PROPN
dpc-4148	2	93	university	university	PROPN
dpc-4148	2	94	,	,	PUNCT
dpc-4148	2	95	denizli	denizli	PROPN
dpc-4148	2	96	,	,	PUNCT
dpc-4148	2	97	türkiye	türkiye	PROPN
dpc-4148	2	98	key	key	ADJ
dpc-4148	2	99	words	word	NOUN
dpc-4148	2	100	:	:	PUNCT
dpc-4148	2	101	morphea	morphea	NUM
dpc-4148	2	102	,	,	PUNCT
dpc-4148	2	103	localized	localized	ADJ
dpc-4148	2	104	scleroderma	scleroderma	NOUN
dpc-4148	2	105	,	,	PUNCT
dpc-4148	2	106	toll	toll	NOUN
dpc-4148	2	107	-	-	PUNCT
dpc-4148	2	108	like	like	ADJ
dpc-4148	2	109	receptors	receptor	NOUN
dpc-4148	2	110	,	,	PUNCT
dpc-4148	2	111	tlr	tlr	PROPN
dpc-4148	2	112	,	,	PUNCT
dpc-4148	2	113	growth	growth	NOUN
dpc-4148	2	114	factors	factor	NOUN
dpc-4148	2	115	citation	citation	NOUN
dpc-4148	2	116	:	:	PUNCT
dpc-4148	2	117	ayvaz	ayvaz	NOUN
dpc-4148	2	118	celik	celik	PROPN
dpc-4148	2	119	h	h	NOUN
dpc-4148	2	120	,	,	PUNCT
dpc-4148	2	121	gurbuz	gurbuz	NOUN
dpc-4148	2	122	n	n	CCONJ
dpc-4148	2	123	,	,	PUNCT
dpc-4148	2	124	turantepe	turantepe	NOUN
dpc-4148	2	125	e	e	NOUN
dpc-4148	2	126	,	,	PUNCT
dpc-4148	2	127	secme	secme	PROPN
dpc-4148	2	128	m	m	PROPN
dpc-4148	2	129	,	,	PUNCT
dpc-4148	2	130	dodurga	dodurga	PROPN
dpc-4148	2	131	y.	y.	NOUN
dpc-4148	2	132	profiling	profiling	NOUN
dpc-4148	2	133	of	of	ADP
dpc-4148	2	134	toll	toll	NOUN
dpc-4148	2	135	-	-	PUNCT
dpc-4148	2	136	like	like	ADJ
dpc-4148	2	137	receptors	receptor	NOUN
dpc-4148	2	138	and	and	CCONJ
dpc-4148	2	139	related	relate	VERB
dpc-4148	2	140	signaling	signal	VERB
dpc-4148	2	141	mediators	mediator	NOUN
dpc-4148	2	142	in	in	ADP
dpc-4148	2	143	the	the	DET
dpc-4148	2	144	pathogenesis	pathogenesis	NOUN
dpc-4148	2	145	of	of	ADP
dpc-4148	2	146	morphea	morphea	PROPN
dpc-4148	2	147	.	.	PUNCT
dpc-4148	3	1	dermatol	dermatol	NOUN
dpc-4148	3	2	pract	pract	PROPN
dpc-4148	3	3	concept	concept	NOUN
dpc-4148	3	4	.	.	PUNCT
dpc-4148	4	1	2024;14(4):e2024219	2024;14(4):e2024219	X
dpc-4148	4	2	.	.	PUNCT
dpc-4148	4	3	doi	doi	NOUN
dpc-4148	4	4	:	:	PUNCT
dpc-4148	4	5	https://doi.org/10.5826/dpc.1404a219	https://doi.org/10.5826/dpc.1404a219	PROPN
dpc-4148	4	6	accepted	accept	VERB
dpc-4148	4	7	:	:	PUNCT
dpc-4148	4	8	june	june	PROPN
dpc-4148	4	9	20	20	NUM
dpc-4148	4	10	,	,	PUNCT
dpc-4148	4	11	2024	2024	NUM
dpc-4148	4	12	;	;	PUNCT
dpc-4148	4	13	published	publish	VERB
dpc-4148	4	14	:	:	PUNCT
dpc-4148	5	1	october	october	PROPN
dpc-4148	5	2	2024	2024	NUM
dpc-4148	5	3	copyright	copyright	NOUN
dpc-4148	5	4	:	:	PUNCT
dpc-4148	5	5	©	©	PROPN
dpc-4148	5	6	2024	2024	NUM
dpc-4148	5	7	ayvaz	ayvaz	NOUN
dpc-4148	5	8	celik	celik	NOUN
dpc-4148	5	9	et	et	PROPN
dpc-4148	5	10	al	al	PROPN
dpc-4148	5	11	.	.	PUNCT
dpc-4148	6	1	this	this	PRON
dpc-4148	6	2	is	be	AUX
dpc-4148	6	3	an	an	DET
dpc-4148	6	4	open	open	ADJ
dpc-4148	6	5	-	-	PUNCT
dpc-4148	6	6	access	access	NOUN
dpc-4148	6	7	article	article	NOUN
dpc-4148	6	8	distributed	distribute	VERB
dpc-4148	6	9	under	under	ADP
dpc-4148	6	10	the	the	DET
dpc-4148	6	11	terms	term	NOUN
dpc-4148	6	12	of	of	ADP
dpc-4148	6	13	the	the	DET
dpc-4148	6	14	creative	creative	ADJ
dpc-4148	6	15	commons	common	NOUN
dpc-4148	6	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-4148	6	17	license	license	NOUN
dpc-4148	6	18	(	(	PUNCT
dpc-4148	6	19	by	by	ADP
dpc-4148	6	20	-	-	PUNCT
dpc-4148	6	21	nc-4.0	nc-4.0	NOUN
dpc-4148	6	22	)	)	PUNCT
dpc-4148	6	23	,	,	PUNCT
dpc-4148	6	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-4148	6	25	,	,	PUNCT
dpc-4148	6	26	which	which	PRON
dpc-4148	6	27	permits	permit	VERB
dpc-4148	6	28	unrestricted	unrestricted	ADJ
dpc-4148	6	29	noncommercial	noncommercial	ADJ
dpc-4148	6	30	use	use	NOUN
dpc-4148	6	31	,	,	PUNCT
dpc-4148	6	32	distribution	distribution	NOUN
dpc-4148	6	33	,	,	PUNCT
dpc-4148	6	34	and	and	CCONJ
dpc-4148	6	35	reproduction	reproduction	NOUN
dpc-4148	6	36	in	in	ADP
dpc-4148	6	37	any	any	DET
dpc-4148	6	38	medium	medium	NOUN
dpc-4148	6	39	,	,	PUNCT
dpc-4148	6	40	provided	provide	VERB
dpc-4148	6	41	the	the	DET
dpc-4148	6	42	original	original	ADJ
dpc-4148	6	43	authors	author	NOUN
dpc-4148	6	44	and	and	CCONJ
dpc-4148	6	45	source	source	NOUN
dpc-4148	6	46	are	be	AUX
dpc-4148	6	47	credited	credit	VERB
dpc-4148	6	48	.	.	PUNCT
dpc-4148	7	1	funding	funding	NOUN
dpc-4148	7	2	:	:	PUNCT
dpc-4148	7	3	this	this	DET
dpc-4148	7	4	study	study	NOUN
dpc-4148	7	5	was	be	AUX
dpc-4148	7	6	supported	support	VERB
dpc-4148	7	7	by	by	ADP
dpc-4148	7	8	a	a	DET
dpc-4148	7	9	funding	funding	NOUN
dpc-4148	7	10	from	from	ADP
dpc-4148	7	11	scientific	scientific	ADJ
dpc-4148	7	12	research	research	NOUN
dpc-4148	7	13	projects	project	NOUN
dpc-4148	7	14	coordinatorship	coordinatorship	NOUN
dpc-4148	7	15	of	of	ADP
dpc-4148	7	16	pamukkale	pamukkale	PROPN
dpc-4148	7	17	university	university	PROPN
dpc-4148	7	18	,	,	PUNCT
dpc-4148	7	19	turkey	turkey	NOUN
dpc-4148	7	20	(	(	PUNCT
dpc-4148	7	21	project	project	NOUN
dpc-4148	7	22	no	no	PRON
dpc-4148	7	23	:	:	PUNCT
dpc-4148	7	24	2021tap004	2021tap004	NUM
dpc-4148	7	25	)	)	PUNCT
dpc-4148	7	26	.	.	PUNCT
dpc-4148	8	1	competing	compete	VERB
dpc-4148	8	2	interests	interest	NOUN
dpc-4148	8	3	:	:	PUNCT
dpc-4148	8	4	none	none	NOUN
dpc-4148	8	5	.	.	PUNCT
dpc-4148	9	1	authorship	authorship	NOUN
dpc-4148	9	2	:	:	PUNCT
dpc-4148	9	3	all	all	DET
dpc-4148	9	4	authors	author	NOUN
dpc-4148	9	5	have	have	AUX
dpc-4148	9	6	contributed	contribute	VERB
dpc-4148	9	7	significantly	significantly	ADV
dpc-4148	9	8	to	to	ADP
dpc-4148	9	9	this	this	DET
dpc-4148	9	10	publication	publication	NOUN
dpc-4148	9	11	.	.	PUNCT
dpc-4148	10	1	corresponding	correspond	VERB
dpc-4148	10	2	author	author	NOUN
dpc-4148	10	3	:	:	PUNCT
dpc-4148	10	4	prof	prof	PROPN
dpc-4148	10	5	.	.	PUNCT
dpc-4148	11	1	dr	dr	PROPN
dpc-4148	11	2	.	.	PROPN
dpc-4148	11	3	yavuz	yavuz	PROPN
dpc-4148	11	4	dodurga	dodurga	PROPN
dpc-4148	11	5	,	,	PUNCT
dpc-4148	11	6	pamukkale	pamukkale	PROPN
dpc-4148	11	7	university	university	NOUN
dpc-4148	11	8	,	,	PUNCT
dpc-4148	11	9	faculty	faculty	NOUN
dpc-4148	11	10	of	of	ADP
dpc-4148	11	11	medicine	medicine	PROPN
dpc-4148	11	12	department	department	PROPN
dpc-4148	11	13	of	of	ADP
dpc-4148	11	14	medical	medical	ADJ
dpc-4148	11	15	biology	biology	NOUN
dpc-4148	11	16	,	,	PUNCT
dpc-4148	11	17	denizli	denizli	PROPN
dpc-4148	11	18	,	,	PUNCT
dpc-4148	11	19	türkiye	türkiye	PROPN
dpc-4148	11	20	.	.	PUNCT
dpc-4148	11	21	email	email	NOUN
dpc-4148	11	22	:	:	PUNCT
dpc-4148	12	1	yavuzdodurga@gmail.com	yavuzdodurga@gmail.com	X
dpc-4148	12	2	introduction	introduction	NOUN
dpc-4148	12	3	:	:	PUNCT
dpc-4148	12	4	morphea	morphea	PROPN
dpc-4148	12	5	,	,	PUNCT
dpc-4148	12	6	also	also	ADV
dpc-4148	12	7	known	know	VERB
dpc-4148	12	8	as	as	ADP
dpc-4148	12	9	localized	localized	ADJ
dpc-4148	12	10	scleroderma	scleroderma	NOUN
dpc-4148	12	11	,	,	PUNCT
dpc-4148	12	12	is	be	AUX
dpc-4148	12	13	a	a	DET
dpc-4148	12	14	rare	rare	ADJ
dpc-4148	12	15	fibrosing	fibrose	VERB
dpc-4148	12	16	inflammatory	inflammatory	ADJ
dpc-4148	12	17	disease	disease	NOUN
dpc-4148	12	18	of	of	ADP
dpc-4148	12	19	unknown	unknown	ADJ
dpc-4148	12	20	pathogenesis	pathogenesis	NOUN
dpc-4148	12	21	.	.	PUNCT
dpc-4148	13	1	objectives	objective	NOUN
dpc-4148	13	2	:	:	PUNCT
dpc-4148	13	3	although	although	SCONJ
dpc-4148	13	4	the	the	DET
dpc-4148	13	5	genetic	genetic	ADJ
dpc-4148	13	6	basis	basis	NOUN
dpc-4148	13	7	for	for	ADP
dpc-4148	13	8	morphea	morphea	NOUN
dpc-4148	13	9	is	be	AUX
dpc-4148	13	10	important	important	ADJ
dpc-4148	13	11	,	,	PUNCT
dpc-4148	13	12	reports	report	NOUN
dpc-4148	13	13	on	on	ADP
dpc-4148	13	14	the	the	DET
dpc-4148	13	15	evaluation	evaluation	NOUN
dpc-4148	13	16	of	of	ADP
dpc-4148	13	17	toll	toll	NOUN
dpc-4148	13	18	-	-	PUNCT
dpc-4148	13	19	like	like	ADJ
dpc-4148	13	20	receptors	receptor	NOUN
dpc-4148	13	21	(	(	PUNCT
dpc-4148	13	22	tlr	tlr	PROPN
dpc-4148	13	23	)	)	PUNCT
dpc-4148	13	24	in	in	ADP
dpc-4148	13	25	this	this	DET
dpc-4148	13	26	disease	disease	NOUN
dpc-4148	13	27	is	be	AUX
dpc-4148	13	28	quite	quite	ADV
dpc-4148	13	29	limited	limited	ADJ
dpc-4148	13	30	.	.	PUNCT
dpc-4148	14	1	we	we	PRON
dpc-4148	14	2	aimed	aim	VERB
dpc-4148	14	3	to	to	PART
dpc-4148	14	4	evaluate	evaluate	VERB
dpc-4148	14	5	tlr	tlr	PROPN
dpc-4148	14	6	expression	expression	NOUN
dpc-4148	14	7	levels	level	NOUN
dpc-4148	14	8	and	and	CCONJ
dpc-4148	14	9	serum	serum	NOUN
dpc-4148	14	10	il-6	il-6	NUM
dpc-4148	14	11	,	,	PUNCT
dpc-4148	14	12	il-17a	il-17a	PROPN
dpc-4148	14	13	,	,	PUNCT
dpc-4148	14	14	tgf	tgf	PROPN
dpc-4148	14	15	-	-	PUNCT
dpc-4148	14	16	β1	β1	PROPN
dpc-4148	14	17	,	,	PUNCT
dpc-4148	14	18	fgf	fgf	PROPN
dpc-4148	14	19	,	,	PUNCT
dpc-4148	14	20	and	and	CCONJ
dpc-4148	14	21	vegf	vegf	PROPN
dpc-4148	14	22	levels	level	NOUN
dpc-4148	14	23	in	in	ADP
dpc-4148	14	24	patients	patient	NOUN
dpc-4148	14	25	with	with	ADP
dpc-4148	14	26	morphea	morphea	PROPN
dpc-4148	14	27	and	and	CCONJ
dpc-4148	14	28	compare	compare	VERB
dpc-4148	14	29	these	these	DET
dpc-4148	14	30	results	result	NOUN
dpc-4148	14	31	with	with	ADP
dpc-4148	14	32	healthy	healthy	ADJ
dpc-4148	14	33	controls	control	NOUN
dpc-4148	14	34	.	.	PUNCT
dpc-4148	15	1	methods	method	NOUN
dpc-4148	15	2	:	:	PUNCT
dpc-4148	15	3	the	the	DET
dpc-4148	15	4	expression	expression	NOUN
dpc-4148	15	5	levels	level	NOUN
dpc-4148	15	6	of	of	ADP
dpc-4148	15	7	tlrs	tlrs	NOUN
dpc-4148	15	8	in	in	ADP
dpc-4148	15	9	the	the	DET
dpc-4148	15	10	lesional	lesional	ADJ
dpc-4148	15	11	and	and	CCONJ
dpc-4148	15	12	non	non	ADJ
dpc-4148	15	13	-	-	ADJ
dpc-4148	15	14	lesional	lesional	ADJ
dpc-4148	15	15	adjacent	adjacent	ADJ
dpc-4148	15	16	skin	skin	NOUN
dpc-4148	15	17	of	of	ADP
dpc-4148	15	18	patients	patient	NOUN
dpc-4148	15	19	with	with	ADP
dpc-4148	15	20	morphea	morphea	PROPN
dpc-4148	15	21	and	and	CCONJ
dpc-4148	15	22	in	in	ADP
dpc-4148	15	23	normal	normal	ADJ
dpc-4148	15	24	skin	skin	NOUN
dpc-4148	15	25	of	of	ADP
dpc-4148	15	26	healthy	healthy	ADJ
dpc-4148	15	27	controls	control	NOUN
dpc-4148	15	28	were	be	AUX
dpc-4148	15	29	evaluated	evaluate	VERB
dpc-4148	15	30	by	by	ADP
dpc-4148	15	31	rt	rt	NOUN
dpc-4148	15	32	-	-	PUNCT
dpc-4148	15	33	pcr	pcr	NOUN
dpc-4148	15	34	,	,	PUNCT
dpc-4148	15	35	whereas	whereas	SCONJ
dpc-4148	15	36	serum	serum	NOUN
dpc-4148	15	37	levels	level	NOUN
dpc-4148	15	38	of	of	ADP
dpc-4148	15	39	il-6	il-6	NUM
dpc-4148	15	40	,	,	PUNCT
dpc-4148	15	41	il-17a	il-17a	PROPN
dpc-4148	15	42	,	,	PUNCT
dpc-4148	15	43	tgf	tgf	PROPN
dpc-4148	15	44	-	-	PUNCT
dpc-4148	15	45	β1	β1	PROPN
dpc-4148	15	46	,	,	PUNCT
dpc-4148	15	47	fgf	fgf	PROPN
dpc-4148	15	48	,	,	PUNCT
dpc-4148	15	49	and	and	CCONJ
dpc-4148	15	50	vegf	vegf	PROPN
dpc-4148	15	51	were	be	AUX
dpc-4148	15	52	evaluated	evaluate	VERB
dpc-4148	15	53	by	by	ADP
dpc-4148	15	54	elisa	elisa	PROPN
dpc-4148	15	55	.	.	PUNCT
dpc-4148	16	1	results	result	NOUN
dpc-4148	16	2	:	:	PUNCT
dpc-4148	16	3	based	base	VERB
dpc-4148	16	4	on	on	ADP
dpc-4148	16	5	our	our	PRON
dpc-4148	16	6	findings	finding	NOUN
dpc-4148	16	7	,	,	PUNCT
dpc-4148	16	8	tlr1	tlr1	PROPN
dpc-4148	16	9	gene	gene	NOUN
dpc-4148	16	10	expression	expression	NOUN
dpc-4148	16	11	increased	increase	VERB
dpc-4148	16	12	34.3	34.3	NUM
dpc-4148	16	13	-	-	NOUN
dpc-4148	16	14	fold	fold	ADJ
dpc-4148	16	15	in	in	ADP
dpc-4148	16	16	the	the	DET
dpc-4148	16	17	lesional	lesional	ADJ
dpc-4148	16	18	skin	skin	NOUN
dpc-4148	16	19	of	of	ADP
dpc-4148	16	20	patients	patient	NOUN
dpc-4148	16	21	with	with	ADP
dpc-4148	16	22	morphea	morphea	PROPN
dpc-4148	16	23	.	.	PUNCT
dpc-4148	17	1	in	in	ADP
dpc-4148	17	2	addition	addition	NOUN
dpc-4148	17	3	,	,	PUNCT
dpc-4148	17	4	il-6	il-6	NUM
dpc-4148	17	5	,	,	PUNCT
dpc-4148	17	6	il-17a	il-17a	PROPN
dpc-4148	17	7	,	,	PUNCT
dpc-4148	17	8	tgf	tgf	PROPN
dpc-4148	17	9	-	-	PUNCT
dpc-4148	17	10	β	β	PROPN
dpc-4148	17	11	,	,	PUNCT
dpc-4148	17	12	fgf	fgf	PROPN
dpc-4148	17	13	,	,	PUNCT
dpc-4148	17	14	and	and	CCONJ
dpc-4148	17	15	vegf	vegf	PROPN
dpc-4148	17	16	were	be	AUX
dpc-4148	17	17	found	find	VERB
dpc-4148	17	18	to	to	PART
dpc-4148	17	19	be	be	AUX
dpc-4148	17	20	higher	high	ADJ
dpc-4148	17	21	in	in	ADP
dpc-4148	17	22	the	the	DET
dpc-4148	17	23	blood	blood	NOUN
dpc-4148	17	24	samples	sample	NOUN
dpc-4148	17	25	of	of	ADP
dpc-4148	17	26	the	the	DET
dpc-4148	17	27	patient	patient	ADJ
dpc-4148	17	28	group	group	NOUN
dpc-4148	17	29	than	than	ADP
dpc-4148	17	30	in	in	ADP
dpc-4148	17	31	the	the	DET
dpc-4148	17	32	healthy	healthy	ADJ
dpc-4148	17	33	group	group	NOUN
dpc-4148	17	34	.	.	PUNCT
dpc-4148	18	1	conclusion	conclusion	NOUN
dpc-4148	18	2	:	:	PUNCT
dpc-4148	18	3	tlrs	tlrs	NOUN
dpc-4148	18	4	are	be	AUX
dpc-4148	18	5	important	important	ADJ
dpc-4148	18	6	parts	part	NOUN
dpc-4148	18	7	of	of	ADP
dpc-4148	18	8	the	the	DET
dpc-4148	18	9	pathogenesis	pathogenesis	NOUN
dpc-4148	18	10	of	of	ADP
dpc-4148	18	11	morphea	morphea	PROPN
dpc-4148	18	12	,	,	PUNCT
dpc-4148	18	13	and	and	CCONJ
dpc-4148	18	14	a	a	DET
dpc-4148	18	15	better	well	ADJ
dpc-4148	18	16	understanding	understanding	NOUN
dpc-4148	18	17	of	of	ADP
dpc-4148	18	18	them	they	PRON
dpc-4148	18	19	will	will	AUX
dpc-4148	18	20	lead	lead	VERB
dpc-4148	18	21	to	to	ADP
dpc-4148	18	22	more	more	ADV
dpc-4148	18	23	directed	directed	ADJ
dpc-4148	18	24	,	,	PUNCT
dpc-4148	18	25	effective	effective	ADJ
dpc-4148	18	26	treatments	treatment	NOUN
dpc-4148	18	27	.	.	PUNCT
dpc-4148	19	1	we	we	PRON
dpc-4148	19	2	believe	believe	VERB
dpc-4148	19	3	that	that	SCONJ
dpc-4148	19	4	this	this	DET
dpc-4148	19	5	study	study	NOUN
dpc-4148	19	6	will	will	AUX
dpc-4148	19	7	be	be	AUX
dpc-4148	19	8	important	important	ADJ
dpc-4148	19	9	for	for	ADP
dpc-4148	19	10	pioneering	pioneer	VERB
dpc-4148	19	11	tlr	tlr	PROPN
dpc-4148	19	12	-	-	PUNCT
dpc-4148	19	13	targeted	target	VERB
dpc-4148	19	14	therapeutic	therapeutic	ADJ
dpc-4148	19	15	approaches	approach	NOUN
dpc-4148	19	16	in	in	ADP
dpc-4148	19	17	the	the	DET
dpc-4148	19	18	treatment	treatment	NOUN
dpc-4148	19	19	of	of	ADP
dpc-4148	19	20	morphea	morphea	NOUN
dpc-4148	19	21	in	in	ADP
dpc-4148	19	22	the	the	DET
dpc-4148	19	23	future	future	NOUN
dpc-4148	19	24	.	.	PUNCT
dpc-4148	20	1	abstract	abstract	ADJ
dpc-4148	20	2	2	2	NUM
dpc-4148	20	3	original	original	ADJ
dpc-4148	20	4	article	article	NOUN
dpc-4148	20	5	|	|	ADV
dpc-4148	20	6	dermatol	dermatol	ADJ
dpc-4148	20	7	pract	pract	NOUN
dpc-4148	20	8	concept	concept	NOUN
dpc-4148	20	9	.	.	PUNCT
dpc-4148	21	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	21	2	introduction	introduction	NOUN
dpc-4148	21	3	morphea	morphea	NOUN
dpc-4148	21	4	,	,	PUNCT
dpc-4148	21	5	also	also	ADV
dpc-4148	21	6	known	know	VERB
dpc-4148	21	7	as	as	ADP
dpc-4148	21	8	a	a	DET
dpc-4148	21	9	localized	localized	ADJ
dpc-4148	21	10	form	form	NOUN
dpc-4148	21	11	of	of	ADP
dpc-4148	21	12	scleroderma	scleroderma	NOUN
dpc-4148	21	13	,	,	PUNCT
dpc-4148	21	14	is	be	AUX
dpc-4148	21	15	a	a	DET
dpc-4148	21	16	rare	rare	ADJ
dpc-4148	21	17	inflammatory	inflammatory	ADJ
dpc-4148	21	18	disease	disease	NOUN
dpc-4148	21	19	characterized	characterize	VERB
dpc-4148	21	20	by	by	ADP
dpc-4148	21	21	fibrosing	fibrose	VERB
dpc-4148	21	22	of	of	ADP
dpc-4148	21	23	the	the	DET
dpc-4148	21	24	skin	skin	NOUN
dpc-4148	21	25	,	,	PUNCT
dpc-4148	21	26	subcutaneous	subcutaneous	ADJ
dpc-4148	21	27	tissues	tissue	NOUN
dpc-4148	21	28	,	,	PUNCT
dpc-4148	21	29	and	and	CCONJ
dpc-4148	21	30	,	,	PUNCT
dpc-4148	21	31	rarely	rarely	ADV
dpc-4148	21	32	,	,	PUNCT
dpc-4148	21	33	underlying	underlying	ADJ
dpc-4148	21	34	organs	organ	NOUN
dpc-4148	21	35	[	[	X
dpc-4148	21	36	1	1	NUM
dpc-4148	21	37	]	]	PUNCT
dpc-4148	21	38	.	.	PUNCT
dpc-4148	22	1	it	it	PRON
dpc-4148	22	2	has	have	VERB
dpc-4148	22	3	several	several	ADJ
dpc-4148	22	4	subtypes	subtype	NOUN
dpc-4148	22	5	,	,	PUNCT
dpc-4148	22	6	which	which	PRON
dpc-4148	22	7	are	be	AUX
dpc-4148	22	8	circumscribed	circumscribe	VERB
dpc-4148	22	9	(	(	PUNCT
dpc-4148	22	10	including	include	VERB
dpc-4148	22	11	a	a	DET
dpc-4148	22	12	superficial	superficial	ADJ
dpc-4148	22	13	and	and	CCONJ
dpc-4148	22	14	deep	deep	ADJ
dpc-4148	22	15	variant	variant	NOUN
dpc-4148	22	16	)	)	PUNCT
dpc-4148	22	17	,	,	PUNCT
dpc-4148	22	18	linear	linear	INTJ
dpc-4148	22	19	,	,	PUNCT
dpc-4148	22	20	generalized	generalize	VERB
dpc-4148	22	21	,	,	PUNCT
dpc-4148	22	22	the	the	DET
dpc-4148	22	23	pansclerotic	pansclerotic	ADJ
dpc-4148	22	24	subtype	subtype	NOUN
dpc-4148	22	25	,	,	PUNCT
dpc-4148	22	26	and	and	CCONJ
dpc-4148	22	27	the	the	DET
dpc-4148	22	28	mixed	mixed	ADJ
dpc-4148	22	29	morphea	morphea	NOUN
dpc-4148	22	30	;	;	PUNCT
dpc-4148	22	31	the	the	DET
dpc-4148	22	32	most	most	ADV
dpc-4148	22	33	common	common	ADJ
dpc-4148	22	34	type	type	NOUN
dpc-4148	22	35	in	in	ADP
dpc-4148	22	36	adults	adult	NOUN
dpc-4148	22	37	is	be	AUX
dpc-4148	22	38	circumscribed	circumscribed	ADJ
dpc-4148	22	39	superficial	superficial	ADJ
dpc-4148	22	40	-	-	PUNCT
dpc-4148	22	41	type	type	NOUN
dpc-4148	22	42	morphea	morphea	NOUN
dpc-4148	23	1	[	[	X
dpc-4148	23	2	2	2	NUM
dpc-4148	23	3	]	]	PUNCT
dpc-4148	23	4	.	.	PUNCT
dpc-4148	24	1	the	the	DET
dpc-4148	24	2	keystone	keystone	PROPN
dpc-4148	24	3	of	of	ADP
dpc-4148	24	4	the	the	DET
dpc-4148	24	5	disease	disease	NOUN
dpc-4148	24	6	is	be	AUX
dpc-4148	24	7	the	the	DET
dpc-4148	24	8	overproduction	overproduction	NOUN
dpc-4148	24	9	of	of	ADP
dpc-4148	24	10	collagen	collagen	NOUN
dpc-4148	24	11	and	and	CCONJ
dpc-4148	24	12	extracellular	extracellular	ADJ
dpc-4148	24	13	matrix	matrix	NOUN
dpc-4148	24	14	deposition	deposition	NOUN
dpc-4148	24	15	;	;	PUNCT
dpc-4148	24	16	however	however	ADV
dpc-4148	24	17	,	,	PUNCT
dpc-4148	24	18	the	the	DET
dpc-4148	24	19	whole	whole	ADJ
dpc-4148	24	20	pathogenesis	pathogenesis	NOUN
dpc-4148	24	21	has	have	AUX
dpc-4148	24	22	not	not	PART
dpc-4148	24	23	yet	yet	ADV
dpc-4148	24	24	been	be	AUX
dpc-4148	24	25	elucidated	elucidate	VERB
dpc-4148	24	26	.	.	PUNCT
dpc-4148	25	1	the	the	DET
dpc-4148	25	2	enlightened	enlighten	VERB
dpc-4148	25	3	part	part	NOUN
dpc-4148	25	4	includes	include	VERB
dpc-4148	25	5	multiple	multiple	ADJ
dpc-4148	25	6	factors	factor	NOUN
dpc-4148	25	7	such	such	ADJ
dpc-4148	25	8	as	as	ADP
dpc-4148	25	9	genetic	genetic	ADJ
dpc-4148	25	10	predisposition	predisposition	NOUN
dpc-4148	25	11	,	,	PUNCT
dpc-4148	25	12	immune	immune	ADJ
dpc-4148	25	13	dysregulation	dysregulation	NOUN
dpc-4148	25	14	,	,	PUNCT
dpc-4148	25	15	and	and	CCONJ
dpc-4148	25	16	environmental	environmental	ADJ
dpc-4148	25	17	factors	factor	NOUN
dpc-4148	25	18	[	[	X
dpc-4148	25	19	3	3	NUM
dpc-4148	25	20	]	]	PUNCT
dpc-4148	25	21	.	.	PUNCT
dpc-4148	26	1	toll	toll	NOUN
dpc-4148	26	2	-	-	PUNCT
dpc-4148	26	3	like	like	ADJ
dpc-4148	26	4	receptors	receptor	NOUN
dpc-4148	26	5	(	(	PUNCT
dpc-4148	26	6	tlrs	tlrs	NOUN
dpc-4148	26	7	)	)	PUNCT
dpc-4148	26	8	are	be	AUX
dpc-4148	26	9	one	one	NUM
dpc-4148	26	10	of	of	ADP
dpc-4148	26	11	the	the	DET
dpc-4148	26	12	pattern	pattern	NOUN
dpc-4148	26	13	recognition	recognition	NOUN
dpc-4148	26	14	receptors	receptor	NOUN
dpc-4148	26	15	required	require	VERB
dpc-4148	26	16	for	for	ADP
dpc-4148	26	17	activation	activation	NOUN
dpc-4148	26	18	of	of	ADP
dpc-4148	26	19	innate	innate	ADJ
dpc-4148	26	20	immunity	immunity	NOUN
dpc-4148	26	21	and	and	CCONJ
dpc-4148	26	22	adaptive	adaptive	ADJ
dpc-4148	26	23	immunity	immunity	NOUN
dpc-4148	26	24	[	[	X
dpc-4148	26	25	4	4	NUM
dpc-4148	26	26	]	]	PUNCT
dpc-4148	26	27	.	.	PUNCT
dpc-4148	27	1	tlrs	tlrs	PROPN
dpc-4148	27	2	are	be	AUX
dpc-4148	27	3	located	locate	VERB
dpc-4148	27	4	on	on	ADP
dpc-4148	27	5	macrophages	macrophage	NOUN
dpc-4148	27	6	and	and	CCONJ
dpc-4148	27	7	other	other	ADJ
dpc-4148	27	8	antigen	antigen	NOUN
dpc-4148	27	9	-	-	PUNCT
dpc-4148	27	10	presenting	present	VERB
dpc-4148	27	11	cells	cell	NOUN
dpc-4148	27	12	that	that	PRON
dpc-4148	27	13	discriminate	discriminate	VERB
dpc-4148	27	14	between	between	ADP
dpc-4148	27	15	self	self	NOUN
dpc-4148	27	16	and	and	CCONJ
dpc-4148	27	17	non	non	ADJ
dpc-4148	27	18	-	-	ADJ
dpc-4148	27	19	self	self	ADJ
dpc-4148	27	20	antigens	antigen	NOUN
dpc-4148	27	21	.	.	PUNCT
dpc-4148	28	1	upon	upon	SCONJ
dpc-4148	28	2	binding	bind	VERB
dpc-4148	28	3	to	to	ADP
dpc-4148	28	4	exogenous	exogenous	ADJ
dpc-4148	28	5	or	or	CCONJ
dpc-4148	28	6	endogenous	endogenous	ADJ
dpc-4148	28	7	antigens	antigen	NOUN
dpc-4148	28	8	,	,	PUNCT
dpc-4148	28	9	tlrs	tlrs	NOUN
dpc-4148	28	10	dimerize	dimerize	NOUN
dpc-4148	28	11	,	,	PUNCT
dpc-4148	28	12	and	and	CCONJ
dpc-4148	28	13	signal	signal	ADJ
dpc-4148	28	14	transduction	transduction	NOUN
dpc-4148	28	15	is	be	AUX
dpc-4148	28	16	achieved	achieve	VERB
dpc-4148	28	17	after	after	ADP
dpc-4148	28	18	some	some	DET
dpc-4148	28	19	conformational	conformational	ADJ
dpc-4148	28	20	changes	change	NOUN
dpc-4148	28	21	.	.	PUNCT
dpc-4148	29	1	activated	activate	VERB
dpc-4148	29	2	tlrs	tlrs	PROPN
dpc-4148	29	3	activate	activate	VERB
dpc-4148	29	4	two	two	NUM
dpc-4148	29	5	different	different	ADJ
dpc-4148	29	6	intracellular	intracellular	ADJ
dpc-4148	29	7	pathways	pathway	NOUN
dpc-4148	29	8	,	,	PUNCT
dpc-4148	29	9	either	either	CCONJ
dpc-4148	29	10	myeloid	myeloid	ADJ
dpc-4148	29	11	differentiation	differentiation	NOUN
dpc-4148	29	12	factor	factor	NOUN
dpc-4148	29	13	88	88	NUM
dpc-4148	29	14	(	(	PUNCT
dpc-4148	29	15	myd88)-dependent	myd88)-dependent	NOUN
dpc-4148	29	16	or	or	CCONJ
dpc-4148	29	17	myd88	myd88	NOUN
dpc-4148	29	18	-	-	PUNCT
dpc-4148	29	19	independent	independent	NOUN
dpc-4148	29	20	[	[	X
dpc-4148	29	21	5	5	NUM
dpc-4148	29	22	]	]	PUNCT
dpc-4148	29	23	.	.	PUNCT
dpc-4148	30	1	with	with	ADP
dpc-4148	30	2	the	the	DET
dpc-4148	30	3	induction	induction	NOUN
dpc-4148	30	4	of	of	ADP
dpc-4148	30	5	immunity	immunity	NOUN
dpc-4148	30	6	by	by	ADP
dpc-4148	30	7	tlrs	tlrs	ADJ
dpc-4148	30	8	,	,	PUNCT
dpc-4148	30	9	dendritic	dendritic	ADJ
dpc-4148	30	10	cell	cell	NOUN
dpc-4148	30	11	maturation	maturation	NOUN
dpc-4148	30	12	and	and	CCONJ
dpc-4148	30	13	activation	activation	NOUN
dpc-4148	30	14	of	of	ADP
dpc-4148	30	15	cd4	cd4	PROPN
dpc-4148	30	16	+	+	PROPN
dpc-4148	30	17	and	and	CCONJ
dpc-4148	30	18	cd8	cd8	PROPN
dpc-4148	30	19	+	+	PROPN
dpc-4148	30	20	t	t	NOUN
dpc-4148	30	21	cells	cell	NOUN
dpc-4148	30	22	are	be	AUX
dpc-4148	30	23	provided	provide	VERB
dpc-4148	30	24	[	[	PUNCT
dpc-4148	30	25	6	6	NUM
dpc-4148	30	26	]	]	PUNCT
dpc-4148	30	27	.	.	PUNCT
dpc-4148	31	1	in	in	ADP
dpc-4148	31	2	addition	addition	NOUN
dpc-4148	31	3	,	,	PUNCT
dpc-4148	31	4	some	some	DET
dpc-4148	31	5	tlrs	tlrs	NOUN
dpc-4148	31	6	that	that	PRON
dpc-4148	31	7	can	can	AUX
dpc-4148	31	8	be	be	AUX
dpc-4148	31	9	expressed	express	VERB
dpc-4148	31	10	directly	directly	ADV
dpc-4148	31	11	in	in	ADP
dpc-4148	31	12	t	t	PROPN
dpc-4148	31	13	and	and	CCONJ
dpc-4148	31	14	b	b	PROPN
dpc-4148	31	15	cells	cell	NOUN
dpc-4148	31	16	can	can	AUX
dpc-4148	31	17	directly	directly	ADV
dpc-4148	31	18	stimulate	stimulate	VERB
dpc-4148	31	19	cell	cell	NOUN
dpc-4148	31	20	differentiation	differentiation	NOUN
dpc-4148	31	21	,	,	PUNCT
dpc-4148	31	22	proliferation	proliferation	NOUN
dpc-4148	31	23	,	,	PUNCT
dpc-4148	31	24	and	and	CCONJ
dpc-4148	31	25	memory	memory	NOUN
dpc-4148	31	26	cell	cell	NOUN
dpc-4148	31	27	and	and	CCONJ
dpc-4148	31	28	antibody	antibody	NOUN
dpc-4148	31	29	production	production	NOUN
dpc-4148	31	30	[	[	X
dpc-4148	31	31	7	7	NUM
dpc-4148	31	32	]	]	PUNCT
dpc-4148	31	33	.	.	PUNCT
dpc-4148	32	1	in	in	ADP
dpc-4148	32	2	many	many	ADJ
dpc-4148	32	3	autoimmune	autoimmune	ADJ
dpc-4148	32	4	diseases	disease	NOUN
dpc-4148	32	5	,	,	PUNCT
dpc-4148	32	6	expressions	expression	NOUN
dpc-4148	32	7	of	of	ADP
dpc-4148	32	8	tlrs	tlrs	NOUN
dpc-4148	32	9	are	be	AUX
dpc-4148	32	10	shown	show	VERB
dpc-4148	32	11	to	to	PART
dpc-4148	32	12	increase	increase	VERB
dpc-4148	32	13	[	[	X
dpc-4148	32	14	8	8	NUM
dpc-4148	32	15	-	-	SYM
dpc-4148	32	16	10	10	NUM
dpc-4148	32	17	]	]	PUNCT
dpc-4148	32	18	.	.	PUNCT
dpc-4148	33	1	tlr4	tlr4	NOUN
dpc-4148	33	2	expression	expression	NOUN
dpc-4148	33	3	is	be	AUX
dpc-4148	33	4	elevated	elevate	VERB
dpc-4148	33	5	in	in	ADP
dpc-4148	33	6	the	the	DET
dpc-4148	33	7	lesional	lesional	ADJ
dpc-4148	33	8	skin	skin	NOUN
dpc-4148	33	9	tissue	tissue	NOUN
dpc-4148	33	10	of	of	ADP
dpc-4148	33	11	patients	patient	NOUN
dpc-4148	33	12	with	with	ADP
dpc-4148	33	13	systemic	systemic	ADJ
dpc-4148	33	14	scleroderma	scleroderma	NOUN
dpc-4148	33	15	,	,	PUNCT
dpc-4148	33	16	and	and	CCONJ
dpc-4148	33	17	induction	induction	NOUN
dpc-4148	33	18	of	of	ADP
dpc-4148	33	19	tlr4	tlr4	NOUN
dpc-4148	33	20	stimulates	stimulate	VERB
dpc-4148	33	21	fibrotic	fibrotic	ADJ
dpc-4148	33	22	gene	gene	NOUN
dpc-4148	33	23	expression	expression	NOUN
dpc-4148	33	24	and	and	CCONJ
dpc-4148	33	25	myofibroblast	myofibroblast	NOUN
dpc-4148	33	26	differentiation	differentiation	NOUN
dpc-4148	33	27	and	and	CCONJ
dpc-4148	33	28	also	also	ADV
dpc-4148	33	29	sensitizes	sensitize	VERB
dpc-4148	33	30	fibroblasts	fibroblast	NOUN
dpc-4148	33	31	to	to	ADP
dpc-4148	33	32	transforming	transform	VERB
dpc-4148	33	33	growth	growth	NOUN
dpc-4148	33	34	factor	factor	NOUN
dpc-4148	33	35	(	(	PUNCT
dpc-4148	34	1	tgf)-β	tgf)-β	NOUN
dpc-4148	34	2	[	[	X
dpc-4148	34	3	11,12	11,12	NUM
dpc-4148	34	4	]	]	PUNCT
dpc-4148	34	5	.	.	PUNCT
dpc-4148	35	1	in	in	ADP
dpc-4148	35	2	the	the	DET
dpc-4148	35	3	pathogenesis	pathogenesis	NOUN
dpc-4148	35	4	of	of	ADP
dpc-4148	35	5	morphea	morphea	PROPN
dpc-4148	35	6	,	,	PUNCT
dpc-4148	35	7	the	the	DET
dpc-4148	35	8	increased	increase	VERB
dpc-4148	35	9	production	production	NOUN
dpc-4148	35	10	of	of	ADP
dpc-4148	35	11	endothelin-1	endothelin-1	PROPN
dpc-4148	35	12	(	(	PUNCT
dpc-4148	35	13	et-1	et-1	X
dpc-4148	35	14	)	)	PUNCT
dpc-4148	35	15	,	,	PUNCT
dpc-4148	35	16	vascular	vascular	ADJ
dpc-4148	35	17	endothelial	endothelial	ADJ
dpc-4148	35	18	growth	growth	NOUN
dpc-4148	35	19	factor	factor	NOUN
dpc-4148	35	20	(	(	PUNCT
dpc-4148	35	21	vegf	vegf	PROPN
dpc-4148	35	22	)	)	PUNCT
dpc-4148	35	23	,	,	PUNCT
dpc-4148	35	24	fibroblast	fibroblast	ADJ
dpc-4148	35	25	growth	growth	NOUN
dpc-4148	35	26	factor	factor	NOUN
dpc-4148	35	27	(	(	PUNCT
dpc-4148	35	28	fgf	fgf	PROPN
dpc-4148	35	29	)	)	PUNCT
dpc-4148	35	30	,	,	PUNCT
dpc-4148	35	31	and	and	CCONJ
dpc-4148	35	32	decreased	decrease	VERB
dpc-4148	35	33	prostacyclin	prostacyclin	PROPN
dpc-4148	35	34	activates	activate	VERB
dpc-4148	35	35	the	the	DET
dpc-4148	35	36	dysfunction	dysfunction	NOUN
dpc-4148	35	37	of	of	ADP
dpc-4148	35	38	endothelial	endothelial	ADJ
dpc-4148	35	39	cells	cell	NOUN
dpc-4148	35	40	and	and	CCONJ
dpc-4148	35	41	also	also	ADV
dpc-4148	35	42	angiogenesis	angiogenesis	VERB
dpc-4148	35	43	.	.	PUNCT
dpc-4148	36	1	in	in	ADP
dpc-4148	36	2	addition	addition	NOUN
dpc-4148	36	3	,	,	PUNCT
dpc-4148	36	4	adhesion	adhesion	NOUN
dpc-4148	36	5	molecules	molecule	NOUN
dpc-4148	36	6	are	be	AUX
dpc-4148	36	7	upregulated	upregulate	VERB
dpc-4148	36	8	,	,	PUNCT
dpc-4148	36	9	and	and	CCONJ
dpc-4148	36	10	reactive	reactive	ADJ
dpc-4148	36	11	oxygen	oxygen	NOUN
dpc-4148	36	12	species	specie	NOUN
dpc-4148	36	13	are	be	AUX
dpc-4148	36	14	generated	generate	VERB
dpc-4148	36	15	in	in	ADP
dpc-4148	36	16	morphea	morphea	PROPN
dpc-4148	37	1	[	[	X
dpc-4148	37	2	13,14	13,14	NUM
dpc-4148	37	3	]	]	PUNCT
dpc-4148	37	4	.	.	PUNCT
dpc-4148	38	1	another	another	DET
dpc-4148	38	2	important	important	ADJ
dpc-4148	38	3	step	step	NOUN
dpc-4148	38	4	in	in	ADP
dpc-4148	38	5	pathogenesis	pathogenesis	NOUN
dpc-4148	38	6	is	be	AUX
dpc-4148	38	7	the	the	DET
dpc-4148	38	8	activation	activation	NOUN
dpc-4148	38	9	of	of	ADP
dpc-4148	38	10	the	the	DET
dpc-4148	38	11	immune	immune	ADJ
dpc-4148	38	12	system	system	NOUN
dpc-4148	38	13	.	.	PUNCT
dpc-4148	39	1	cd4	cd4	PROPN
dpc-4148	39	2	+	+	PROPN
dpc-4148	39	3	t	t	PROPN
dpc-4148	39	4	lymphocytes	lymphocyte	NOUN
dpc-4148	39	5	are	be	AUX
dpc-4148	39	6	especially	especially	ADV
dpc-4148	39	7	predominant	predominant	ADJ
dpc-4148	39	8	and	and	CCONJ
dpc-4148	39	9	cause	cause	VERB
dpc-4148	39	10	the	the	DET
dpc-4148	39	11	secretion	secretion	NOUN
dpc-4148	39	12	of	of	ADP
dpc-4148	39	13	interleukin	interleukin	NOUN
dpc-4148	39	14	(	(	PUNCT
dpc-4148	39	15	il)-2	il)-2	NOUN
dpc-4148	39	16	,	,	PUNCT
dpc-4148	39	17	il-4	il-4	NOUN
dpc-4148	39	18	,	,	PUNCT
dpc-4148	39	19	il-6	il-6	NOUN
dpc-4148	39	20	,	,	PUNCT
dpc-4148	39	21	and	and	CCONJ
dpc-4148	39	22	gfs	gfs	NOUN
dpc-4148	39	23	such	such	ADJ
dpc-4148	39	24	as	as	ADP
dpc-4148	39	25	tgf	tgf	PROPN
dpc-4148	39	26	-	-	PUNCT
dpc-4148	39	27	β	β	PROPN
dpc-4148	39	28	that	that	PRON
dpc-4148	39	29	initiate	initiate	VERB
dpc-4148	39	30	and/	and/	NOUN
dpc-4148	39	31	or	or	CCONJ
dpc-4148	39	32	promote	promote	VERB
dpc-4148	39	33	fibrosis	fibrosis	NOUN
dpc-4148	39	34	and	and	CCONJ
dpc-4148	39	35	vascular	vascular	ADJ
dpc-4148	39	36	injury	injury	NOUN
dpc-4148	39	37	.	.	PUNCT
dpc-4148	40	1	among	among	ADP
dpc-4148	40	2	these	these	DET
dpc-4148	40	3	substances	substance	NOUN
dpc-4148	40	4	,	,	PUNCT
dpc-4148	40	5	especially	especially	ADV
dpc-4148	40	6	il-4	il-4	PRON
dpc-4148	40	7	induces	induce	VERB
dpc-4148	40	8	tgf	tgf	PROPN
dpc-4148	40	9	-	-	PUNCT
dpc-4148	40	10	β	β	NOUN
dpc-4148	40	11	production	production	NOUN
dpc-4148	40	12	as	as	ADV
dpc-4148	40	13	well	well	ADV
dpc-4148	40	14	as	as	ADP
dpc-4148	40	15	collagen	collagen	NOUN
dpc-4148	40	16	production	production	NOUN
dpc-4148	40	17	by	by	ADP
dpc-4148	40	18	fibroblasts	fibroblast	NOUN
dpc-4148	40	19	.	.	PUNCT
dpc-4148	41	1	in	in	ADP
dpc-4148	41	2	addition	addition	NOUN
dpc-4148	41	3	to	to	ADP
dpc-4148	41	4	producing	produce	VERB
dpc-4148	41	5	excess	excess	ADJ
dpc-4148	41	6	collagen	collagen	NOUN
dpc-4148	41	7	,	,	PUNCT
dpc-4148	41	8	fibroblasts	fibroblast	NOUN
dpc-4148	41	9	in	in	ADP
dpc-4148	41	10	patients	patient	NOUN
dpc-4148	41	11	with	with	ADP
dpc-4148	41	12	scleroderma	scleroderma	NOUN
dpc-4148	41	13	also	also	ADV
dpc-4148	41	14	give	give	VERB
dpc-4148	41	15	an	an	DET
dpc-4148	41	16	increased	increase	VERB
dpc-4148	41	17	response	response	NOUN
dpc-4148	41	18	to	to	ADP
dpc-4148	41	19	molecules	molecule	NOUN
dpc-4148	41	20	such	such	ADJ
dpc-4148	41	21	as	as	ADP
dpc-4148	41	22	tgf	tgf	PROPN
dpc-4148	41	23	-	-	PUNCT
dpc-4148	41	24	β	β	PROPN
dpc-4148	41	25	,	,	PUNCT
dpc-4148	41	26	et1	et1	NOUN
dpc-4148	41	27	,	,	PUNCT
dpc-4148	41	28	and	and	CCONJ
dpc-4148	41	29	platelet	platelet	ADJ
dpc-4148	41	30	-	-	PUNCT
dpc-4148	41	31	derived	derive	VERB
dpc-4148	41	32	growth	growth	NOUN
dpc-4148	41	33	factor	factor	NOUN
dpc-4148	41	34	(	(	PUNCT
dpc-4148	41	35	pdgf	pdgf	NOUN
dpc-4148	41	36	)	)	PUNCT
dpc-4148	42	1	[	[	X
dpc-4148	42	2	15	15	NUM
dpc-4148	42	3	]	]	PUNCT
dpc-4148	42	4	.	.	PUNCT
dpc-4148	43	1	according	accord	VERB
dpc-4148	43	2	to	to	ADP
dpc-4148	43	3	the	the	DET
dpc-4148	43	4	information	information	NOUN
dpc-4148	43	5	obtained	obtain	VERB
dpc-4148	43	6	from	from	ADP
dpc-4148	43	7	studies	study	NOUN
dpc-4148	43	8	,	,	PUNCT
dpc-4148	43	9	all	all	DET
dpc-4148	43	10	t	t	PROPN
dpc-4148	43	11	helper	helper	NOUN
dpc-4148	43	12	1	1	NUM
dpc-4148	43	13	(	(	PUNCT
dpc-4148	43	14	th1	th1	NOUN
dpc-4148	43	15	)	)	PUNCT
dpc-4148	43	16	,	,	PUNCT
dpc-4148	43	17	th2	th2	PROPN
dpc-4148	43	18	,	,	PUNCT
dpc-4148	43	19	and	and	CCONJ
dpc-4148	43	20	th17	th17	PROPN
dpc-4148	43	21	cytokines	cytokine	NOUN
dpc-4148	43	22	may	may	AUX
dpc-4148	43	23	contribute	contribute	VERB
dpc-4148	43	24	equally	equally	ADV
dpc-4148	43	25	to	to	ADP
dpc-4148	43	26	the	the	DET
dpc-4148	43	27	pathogenesis	pathogenesis	NOUN
dpc-4148	43	28	of	of	ADP
dpc-4148	43	29	morphea	morphea	PROPN
dpc-4148	44	1	[	[	X
dpc-4148	44	2	16	16	NUM
dpc-4148	44	3	]	]	PUNCT
dpc-4148	44	4	.	.	PUNCT
dpc-4148	45	1	objectives	objective	VERB
dpc-4148	45	2	a	a	DET
dpc-4148	45	3	better	well	ADJ
dpc-4148	45	4	understanding	understanding	NOUN
dpc-4148	45	5	of	of	ADP
dpc-4148	45	6	the	the	DET
dpc-4148	45	7	pathophysiology	pathophysiology	NOUN
dpc-4148	45	8	of	of	ADP
dpc-4148	45	9	morphea	morphea	NOUN
dpc-4148	45	10	will	will	AUX
dpc-4148	45	11	lead	lead	VERB
dpc-4148	45	12	to	to	ADP
dpc-4148	45	13	more	more	ADV
dpc-4148	45	14	directed	directed	ADJ
dpc-4148	45	15	and	and	CCONJ
dpc-4148	45	16	effective	effective	ADJ
dpc-4148	45	17	treatments	treatment	NOUN
dpc-4148	45	18	.	.	PUNCT
dpc-4148	46	1	in	in	ADP
dpc-4148	46	2	addition	addition	NOUN
dpc-4148	46	3	,	,	PUNCT
dpc-4148	46	4	morphea	morphea	PROPN
dpc-4148	46	5	causes	cause	VERB
dpc-4148	46	6	permanent	permanent	ADJ
dpc-4148	46	7	deformity	deformity	NOUN
dpc-4148	46	8	and	and	CCONJ
dpc-4148	46	9	functional	functional	ADJ
dpc-4148	46	10	sequelae	sequelae	NOUN
dpc-4148	46	11	and	and	CCONJ
dpc-4148	46	12	has	have	VERB
dpc-4148	46	13	a	a	DET
dpc-4148	46	14	great	great	ADJ
dpc-4148	46	15	impact	impact	NOUN
dpc-4148	46	16	on	on	ADP
dpc-4148	46	17	patients	patient	NOUN
dpc-4148	46	18	’	’	PART
dpc-4148	46	19	life	life	NOUN
dpc-4148	46	20	quality	quality	NOUN
dpc-4148	46	21	of	of	ADP
dpc-4148	46	22	[	[	X
dpc-4148	46	23	17	17	NUM
dpc-4148	46	24	]	]	PUNCT
dpc-4148	46	25	.	.	PUNCT
dpc-4148	47	1	there	there	PRON
dpc-4148	47	2	is	be	VERB
dpc-4148	47	3	no	no	DET
dpc-4148	47	4	curative	curative	ADJ
dpc-4148	47	5	treatment	treatment	NOUN
dpc-4148	47	6	option	option	NOUN
dpc-4148	47	7	for	for	ADP
dpc-4148	47	8	morphea	morphea	NOUN
dpc-4148	47	9	yet	yet	ADV
dpc-4148	48	1	[	[	X
dpc-4148	48	2	16	16	NUM
dpc-4148	48	3	]	]	PUNCT
dpc-4148	48	4	.	.	PUNCT
dpc-4148	49	1	the	the	DET
dpc-4148	49	2	present	present	ADJ
dpc-4148	49	3	study	study	NOUN
dpc-4148	49	4	aimed	aim	VERB
dpc-4148	49	5	to	to	PART
dpc-4148	49	6	evaluate	evaluate	VERB
dpc-4148	49	7	and	and	CCONJ
dpc-4148	49	8	compare	compare	VERB
dpc-4148	49	9	the	the	DET
dpc-4148	49	10	expression	expression	NOUN
dpc-4148	49	11	levels	level	NOUN
dpc-4148	49	12	of	of	ADP
dpc-4148	49	13	tlrs	tlrs	NOUN
dpc-4148	49	14	in	in	ADP
dpc-4148	49	15	the	the	DET
dpc-4148	49	16	lesional	lesional	ADJ
dpc-4148	49	17	and	and	CCONJ
dpc-4148	49	18	non	non	ADJ
dpc-4148	49	19	-	-	ADJ
dpc-4148	49	20	lesional	lesional	ADJ
dpc-4148	49	21	adjacent	adjacent	ADJ
dpc-4148	49	22	skin	skin	NOUN
dpc-4148	49	23	of	of	ADP
dpc-4148	49	24	patients	patient	NOUN
dpc-4148	49	25	with	with	ADP
dpc-4148	49	26	morphea	morphea	NOUN
dpc-4148	49	27	with	with	ADP
dpc-4148	49	28	normal	normal	ADJ
dpc-4148	49	29	skin	skin	NOUN
dpc-4148	49	30	of	of	ADP
dpc-4148	49	31	healthy	healthy	ADJ
dpc-4148	49	32	controls	control	NOUN
dpc-4148	49	33	as	as	ADV
dpc-4148	49	34	well	well	ADV
dpc-4148	49	35	as	as	ADP
dpc-4148	49	36	the	the	DET
dpc-4148	49	37	serum	serum	NOUN
dpc-4148	49	38	levels	level	NOUN
dpc-4148	49	39	of	of	ADP
dpc-4148	49	40	il-6	il-6	NUM
dpc-4148	49	41	,	,	PUNCT
dpc-4148	49	42	il-17a	il-17a	PROPN
dpc-4148	49	43	,	,	PUNCT
dpc-4148	49	44	tgf	tgf	PROPN
dpc-4148	49	45	-	-	PUNCT
dpc-4148	49	46	β1	β1	PROPN
dpc-4148	49	47	,	,	PUNCT
dpc-4148	49	48	fgf	fgf	PROPN
dpc-4148	49	49	,	,	PUNCT
dpc-4148	49	50	and	and	CCONJ
dpc-4148	49	51	vegf	vegf	NOUN
dpc-4148	49	52	of	of	ADP
dpc-4148	49	53	both	both	DET
dpc-4148	49	54	groups	group	NOUN
dpc-4148	49	55	.	.	PUNCT
dpc-4148	50	1	in	in	ADP
dpc-4148	50	2	addition	addition	NOUN
dpc-4148	50	3	,	,	PUNCT
dpc-4148	50	4	this	this	DET
dpc-4148	50	5	study	study	NOUN
dpc-4148	50	6	aimed	aim	VERB
dpc-4148	50	7	to	to	ADP
dpc-4148	50	8	pioneer	pioneer	PROPN
dpc-4148	50	9	tlr	tlr	PROPN
dpc-4148	50	10	-	-	PUNCT
dpc-4148	50	11	targeted	target	VERB
dpc-4148	50	12	therapeutic	therapeutic	ADJ
dpc-4148	50	13	approaches	approach	NOUN
dpc-4148	50	14	for	for	ADP
dpc-4148	50	15	morphea	morphea	NOUN
dpc-4148	50	16	that	that	PRON
dpc-4148	50	17	may	may	AUX
dpc-4148	50	18	emerge	emerge	VERB
dpc-4148	50	19	in	in	ADP
dpc-4148	50	20	the	the	DET
dpc-4148	50	21	future	future	NOUN
dpc-4148	50	22	.	.	PUNCT
dpc-4148	51	1	methods	method	NOUN
dpc-4148	51	2	this	this	DET
dpc-4148	51	3	prospective	prospective	ADJ
dpc-4148	51	4	case	case	NOUN
dpc-4148	51	5	-	-	PUNCT
dpc-4148	51	6	control	control	NOUN
dpc-4148	51	7	study	study	NOUN
dpc-4148	51	8	was	be	AUX
dpc-4148	51	9	conducted	conduct	VERB
dpc-4148	51	10	according	accord	VERB
dpc-4148	51	11	to	to	ADP
dpc-4148	51	12	the	the	DET
dpc-4148	51	13	declaration	declaration	NOUN
dpc-4148	51	14	of	of	ADP
dpc-4148	51	15	helsinki	helsinki	PROPN
dpc-4148	51	16	guidelines	guideline	NOUN
dpc-4148	51	17	and	and	CCONJ
dpc-4148	51	18	was	be	AUX
dpc-4148	51	19	ethically	ethically	ADV
dpc-4148	51	20	approved	approve	VERB
dpc-4148	51	21	by	by	ADP
dpc-4148	51	22	the	the	DET
dpc-4148	51	23	ethics	ethic	NOUN
dpc-4148	51	24	committee	committee	PROPN
dpc-4148	51	25	(	(	PUNCT
dpc-4148	51	26	decision	decision	NOUN
dpc-4148	51	27	220	220	NUM
dpc-4148	51	28	on	on	ADP
dpc-4148	51	29	10.06.2021	10.06.2021	NUM
dpc-4148	51	30	)	)	PUNCT
dpc-4148	51	31	.	.	PUNCT
dpc-4148	52	1	all	all	DET
dpc-4148	52	2	participants	participant	NOUN
dpc-4148	52	3	in	in	ADP
dpc-4148	52	4	the	the	DET
dpc-4148	52	5	study	study	NOUN
dpc-4148	52	6	provided	provide	VERB
dpc-4148	52	7	informed	informed	ADJ
dpc-4148	52	8	consent	consent	NOUN
dpc-4148	52	9	.	.	PUNCT
dpc-4148	53	1	study	study	NOUN
dpc-4148	53	2	population	population	NOUN
dpc-4148	53	3	fifteen	fifteen	NUM
dpc-4148	53	4	patients	patient	NOUN
dpc-4148	53	5	with	with	ADP
dpc-4148	53	6	morphea	morphea	NOUN
dpc-4148	53	7	aged	age	VERB
dpc-4148	53	8	between	between	ADP
dpc-4148	53	9	18	18	NUM
dpc-4148	53	10	and	and	CCONJ
dpc-4148	53	11	65	65	NUM
dpc-4148	53	12	years	year	NOUN
dpc-4148	53	13	who	who	PRON
dpc-4148	53	14	were	be	AUX
dpc-4148	53	15	clinically	clinically	ADV
dpc-4148	53	16	and	and	CCONJ
dpc-4148	53	17	histopathologically	histopathologically	ADV
dpc-4148	53	18	diagnosed	diagnose	VERB
dpc-4148	53	19	with	with	ADP
dpc-4148	53	20	morphea	morphea	NOUN
dpc-4148	53	21	attending	attend	VERB
dpc-4148	53	22	the	the	DET
dpc-4148	53	23	university	university	NOUN
dpc-4148	53	24	hospital	hospital	NOUN
dpc-4148	53	25	dermatology	dermatology	NOUN
dpc-4148	53	26	outpatient	outpatient	NOUN
dpc-4148	53	27	clinic	clinic	NOUN
dpc-4148	53	28	between	between	ADP
dpc-4148	53	29	july	july	PROPN
dpc-4148	53	30	2021	2021	NUM
dpc-4148	53	31	and	and	CCONJ
dpc-4148	53	32	february	february	PROPN
dpc-4148	53	33	2022	2022	NUM
dpc-4148	53	34	were	be	AUX
dpc-4148	53	35	included	include	VERB
dpc-4148	53	36	in	in	ADP
dpc-4148	53	37	the	the	DET
dpc-4148	53	38	study	study	NOUN
dpc-4148	53	39	.	.	PUNCT
dpc-4148	54	1	a	a	DET
dpc-4148	54	2	detailed	detailed	ADJ
dpc-4148	54	3	anamnesis	anamnesis	NOUN
dpc-4148	54	4	was	be	AUX
dpc-4148	54	5	taken	take	VERB
dpc-4148	54	6	,	,	PUNCT
dpc-4148	54	7	a	a	DET
dpc-4148	54	8	skin	skin	NOUN
dpc-4148	54	9	examination	examination	NOUN
dpc-4148	54	10	was	be	AUX
dpc-4148	54	11	performed	perform	VERB
dpc-4148	54	12	by	by	ADP
dpc-4148	54	13	the	the	DET
dpc-4148	54	14	same	same	ADJ
dpc-4148	54	15	dermatologist	dermatologist	NOUN
dpc-4148	54	16	,	,	PUNCT
dpc-4148	54	17	and	and	CCONJ
dpc-4148	54	18	the	the	DET
dpc-4148	54	19	severity	severity	NOUN
dpc-4148	54	20	of	of	ADP
dpc-4148	54	21	the	the	DET
dpc-4148	54	22	disease	disease	NOUN
dpc-4148	54	23	was	be	AUX
dpc-4148	54	24	evaluated	evaluate	VERB
dpc-4148	54	25	according	accord	VERB
dpc-4148	54	26	to	to	ADP
dpc-4148	54	27	the	the	DET
dpc-4148	54	28	localized	localize	VERB
dpc-4148	54	29	scleroderma	scleroderma	NOUN
dpc-4148	54	30	assessment	assessment	NOUN
dpc-4148	54	31	tool	tool	NOUN
dpc-4148	54	32	(	(	PUNCT
dpc-4148	54	33	loscat	loscat	PROPN
dpc-4148	54	34	)	)	PUNCT
dpc-4148	55	1	[	[	X
dpc-4148	55	2	18	18	NUM
dpc-4148	55	3	]	]	PUNCT
dpc-4148	55	4	.	.	PUNCT
dpc-4148	56	1	loscat	loscat	PROPN
dpc-4148	56	2	consists	consist	VERB
dpc-4148	56	3	of	of	ADP
dpc-4148	56	4	two	two	NUM
dpc-4148	56	5	domains	domain	NOUN
dpc-4148	56	6	,	,	PUNCT
dpc-4148	56	7	a	a	DET
dpc-4148	56	8	modified	modify	VERB
dpc-4148	56	9	localized	localize	VERB
dpc-4148	56	10	skin	skin	NOUN
dpc-4148	56	11	severity	severity	NOUN
dpc-4148	56	12	index	index	NOUN
dpc-4148	56	13	(	(	PUNCT
dpc-4148	56	14	mlossi	mlossi	NOUN
dpc-4148	56	15	)	)	PUNCT
dpc-4148	56	16	and	and	CCONJ
dpc-4148	56	17	the	the	DET
dpc-4148	56	18	localized	localized	ADJ
dpc-4148	56	19	scleroderma	scleroderma	NOUN
dpc-4148	56	20	damage	damage	NOUN
dpc-4148	56	21	index	index	NOUN
dpc-4148	56	22	(	(	PUNCT
dpc-4148	56	23	losdi	losdi	PROPN
dpc-4148	56	24	)	)	PUNCT
dpc-4148	56	25	,	,	PUNCT
dpc-4148	56	26	which	which	PRON
dpc-4148	56	27	measures	measure	VERB
dpc-4148	56	28	the	the	DET
dpc-4148	56	29	severity	severity	NOUN
dpc-4148	56	30	of	of	ADP
dpc-4148	56	31	morphea	morphea	PROPN
dpc-4148	56	32	.	.	PUNCT
dpc-4148	57	1	all	all	DET
dpc-4148	57	2	participants	participant	NOUN
dpc-4148	57	3	were	be	AUX
dpc-4148	57	4	selected	select	VERB
dpc-4148	57	5	from	from	ADP
dpc-4148	57	6	patients	patient	NOUN
dpc-4148	57	7	who	who	PRON
dpc-4148	57	8	had	have	AUX
dpc-4148	57	9	not	not	PART
dpc-4148	57	10	been	be	AUX
dpc-4148	57	11	treated	treat	VERB
dpc-4148	57	12	with	with	ADP
dpc-4148	57	13	systemic	systemic	ADJ
dpc-4148	57	14	therapy	therapy	NOUN
dpc-4148	57	15	,	,	PUNCT
dpc-4148	57	16	including	include	VERB
dpc-4148	57	17	phototherapy	phototherapy	NOUN
dpc-4148	57	18	,	,	PUNCT
dpc-4148	57	19	for	for	ADP
dpc-4148	57	20	at	at	ADV
dpc-4148	57	21	least	least	ADV
dpc-4148	57	22	eight	eight	NUM
dpc-4148	57	23	weeks	week	NOUN
dpc-4148	57	24	before	before	ADP
dpc-4148	57	25	the	the	DET
dpc-4148	57	26	initiation	initiation	NOUN
dpc-4148	57	27	of	of	ADP
dpc-4148	57	28	the	the	DET
dpc-4148	57	29	study	study	NOUN
dpc-4148	57	30	.	.	PUNCT
dpc-4148	58	1	eleven	eleven	NUM
dpc-4148	58	2	ageand	ageand	NOUN
dpc-4148	58	3	sex	sex	NOUN
dpc-4148	58	4	-	-	PUNCT
dpc-4148	58	5	matched	match	VERB
dpc-4148	58	6	healthy	healthy	ADJ
dpc-4148	58	7	volunteers	volunteer	NOUN
dpc-4148	58	8	who	who	PRON
dpc-4148	58	9	did	do	AUX
dpc-4148	58	10	not	not	PART
dpc-4148	58	11	have	have	VERB
dpc-4148	58	12	any	any	DET
dpc-4148	58	13	systemic	systemic	ADJ
dpc-4148	58	14	inflammatory	inflammatory	ADJ
dpc-4148	58	15	disease	disease	NOUN
dpc-4148	58	16	,	,	PUNCT
dpc-4148	58	17	including	include	VERB
dpc-4148	58	18	cardiovascular	cardiovascular	ADJ
dpc-4148	58	19	and/or	and/or	CCONJ
dpc-4148	58	20	neurovascular	neurovascular	ADJ
dpc-4148	58	21	diseases	disease	NOUN
dpc-4148	58	22	,	,	PUNCT
dpc-4148	58	23	or	or	CCONJ
dpc-4148	58	24	inflammatory	inflammatory	ADJ
dpc-4148	58	25	skin	skin	NOUN
dpc-4148	58	26	diseases	disease	NOUN
dpc-4148	58	27	and	and	CCONJ
dpc-4148	58	28	who	who	PRON
dpc-4148	58	29	did	do	AUX
dpc-4148	58	30	not	not	PART
dpc-4148	58	31	take	take	VERB
dpc-4148	58	32	regular	regular	ADJ
dpc-4148	58	33	medication	medication	NOUN
dpc-4148	58	34	for	for	ADP
dpc-4148	58	35	any	any	DET
dpc-4148	58	36	reason	reason	NOUN
dpc-4148	58	37	were	be	AUX
dpc-4148	58	38	also	also	ADV
dpc-4148	58	39	included	include	VERB
dpc-4148	58	40	as	as	ADP
dpc-4148	58	41	the	the	DET
dpc-4148	58	42	control	control	NOUN
dpc-4148	58	43	group	group	NOUN
dpc-4148	58	44	.	.	PUNCT
dpc-4148	59	1	patients	patient	NOUN
dpc-4148	59	2	with	with	ADP
dpc-4148	59	3	a	a	DET
dpc-4148	59	4	history	history	NOUN
dpc-4148	59	5	of	of	ADP
dpc-4148	59	6	cardiovascular	cardiovascular	ADJ
dpc-4148	59	7	or	or	CCONJ
dpc-4148	59	8	cerebrovascular	cerebrovascular	ADJ
dpc-4148	59	9	accident	accident	NOUN
dpc-4148	59	10	,	,	PUNCT
dpc-4148	59	11	active	active	ADJ
dpc-4148	59	12	infection	infection	NOUN
dpc-4148	59	13	,	,	PUNCT
dpc-4148	59	14	and	and	CCONJ
dpc-4148	59	15	uncontrolled	uncontrolled	ADJ
dpc-4148	59	16	inflammatory	inflammatory	ADJ
dpc-4148	59	17	systemic	systemic	ADJ
dpc-4148	59	18	disease	disease	NOUN
dpc-4148	59	19	,	,	PUNCT
dpc-4148	59	20	including	include	VERB
dpc-4148	59	21	diabetes	diabetes	NOUN
dpc-4148	59	22	mellitus	mellitus	NOUN
dpc-4148	59	23	(	(	PUNCT
dpc-4148	59	24	dm	dm	PROPN
dpc-4148	59	25	)	)	PUNCT
dpc-4148	59	26	and	and	CCONJ
dpc-4148	59	27	skin	skin	NOUN
dpc-4148	59	28	diseases	disease	NOUN
dpc-4148	59	29	,	,	PUNCT
dpc-4148	59	30	other	other	ADJ
dpc-4148	59	31	autoimmune	autoimmune	ADJ
dpc-4148	59	32	diseases	disease	NOUN
dpc-4148	59	33	,	,	PUNCT
dpc-4148	59	34	and/or	and/or	CCONJ
dpc-4148	59	35	malignancy	malignancy	NOUN
dpc-4148	59	36	in	in	ADP
dpc-4148	59	37	the	the	DET
dpc-4148	59	38	last	last	ADJ
dpc-4148	59	39	five	five	NUM
dpc-4148	59	40	years	year	NOUN
dpc-4148	59	41	were	be	AUX
dpc-4148	59	42	excluded	exclude	VERB
dpc-4148	59	43	from	from	ADP
dpc-4148	59	44	the	the	DET
dpc-4148	59	45	study	study	NOUN
dpc-4148	59	46	.	.	PUNCT
dpc-4148	60	1	original	original	ADJ
dpc-4148	60	2	article	article	NOUN
dpc-4148	60	3	|	|	ADV
dpc-4148	60	4	dermatol	dermatol	ADJ
dpc-4148	60	5	pract	pract	NOUN
dpc-4148	60	6	concept	concept	NOUN
dpc-4148	60	7	.	.	PUNCT
dpc-4148	61	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	61	2	3	3	NUM
dpc-4148	61	3	lesions	lesion	NOUN
dpc-4148	61	4	and	and	CCONJ
dpc-4148	61	5	non	non	ADJ
dpc-4148	61	6	-	-	ADJ
dpc-4148	61	7	lesional	lesional	ADJ
dpc-4148	61	8	skin	skin	NOUN
dpc-4148	61	9	samples	sample	NOUN
dpc-4148	61	10	(	(	PUNCT
dpc-4148	61	11	both	both	DET
dpc-4148	61	12	3	3	NUM
dpc-4148	61	13	mm	mm	NOUN
dpc-4148	61	14	in	in	ADP
dpc-4148	61	15	size	size	NOUN
dpc-4148	61	16	)	)	PUNCT
dpc-4148	61	17	were	be	AUX
dpc-4148	61	18	obtained	obtain	VERB
dpc-4148	61	19	from	from	ADP
dpc-4148	61	20	each	each	DET
dpc-4148	61	21	patient	patient	NOUN
dpc-4148	61	22	with	with	ADP
dpc-4148	61	23	morphea	morphea	PROPN
dpc-4148	61	24	and	and	CCONJ
dpc-4148	61	25	similarly	similarly	ADV
dpc-4148	61	26	sized	sized	ADJ
dpc-4148	61	27	skin	skin	NOUN
dpc-4148	61	28	tissue	tissue	NOUN
dpc-4148	61	29	from	from	ADP
dpc-4148	61	30	healthy	healthy	ADJ
dpc-4148	61	31	controls	control	NOUN
dpc-4148	61	32	.	.	PUNCT
dpc-4148	62	1	in	in	ADP
dpc-4148	62	2	addition	addition	NOUN
dpc-4148	62	3	,	,	PUNCT
dpc-4148	62	4	4	4	NUM
dpc-4148	62	5	ccs	ccs	NOUN
dpc-4148	62	6	of	of	ADP
dpc-4148	62	7	peripheral	peripheral	ADJ
dpc-4148	62	8	blood	blood	NOUN
dpc-4148	62	9	taken	take	VERB
dpc-4148	62	10	from	from	ADP
dpc-4148	62	11	each	each	PRON
dpc-4148	62	12	of	of	ADP
dpc-4148	62	13	the	the	DET
dpc-4148	62	14	participants	participant	NOUN
dpc-4148	62	15	were	be	AUX
dpc-4148	62	16	centrifuged	centrifuge	VERB
dpc-4148	62	17	at	at	ADP
dpc-4148	62	18	2000xg	2000xg	NOUN
dpc-4148	62	19	for	for	ADP
dpc-4148	62	20	10	10	NUM
dpc-4148	62	21	minutes	minute	NOUN
dpc-4148	62	22	.	.	PUNCT
dpc-4148	63	1	all	all	DET
dpc-4148	63	2	skin	skin	NOUN
dpc-4148	63	3	tissues	tissue	NOUN
dpc-4148	63	4	and	and	CCONJ
dpc-4148	63	5	blood	blood	NOUN
dpc-4148	63	6	samples	sample	NOUN
dpc-4148	63	7	(	(	PUNCT
dpc-4148	63	8	after	after	ADP
dpc-4148	63	9	centrifugation	centrifugation	NOUN
dpc-4148	63	10	)	)	PUNCT
dpc-4148	63	11	were	be	AUX
dpc-4148	63	12	transferred	transfer	VERB
dpc-4148	63	13	to	to	ADP
dpc-4148	63	14	1.5	1.5	NUM
dpc-4148	63	15	ml	ml	NOUN
dpc-4148	63	16	eppendorf	eppendorf	PROPN
dpc-4148	63	17	tubes	tube	NOUN
dpc-4148	63	18	without	without	ADP
dpc-4148	63	19	dnase	dnase	NOUN
dpc-4148	63	20	rnase	rnase	PROPN
dpc-4148	63	21	and	and	CCONJ
dpc-4148	63	22	stored	store	VERB
dpc-4148	63	23	in	in	ADP
dpc-4148	63	24	the	the	DET
dpc-4148	63	25	refrigerator	refrigerator	NOUN
dpc-4148	63	26	at	at	ADP
dpc-4148	63	27	-20	-20	NUM
dpc-4148	63	28	˚c	˚c	PROPN
dpc-4148	63	29	until	until	ADP
dpc-4148	63	30	the	the	DET
dpc-4148	63	31	study	study	NOUN
dpc-4148	63	32	day	day	NOUN
dpc-4148	63	33	.	.	PUNCT
dpc-4148	64	1	then	then	ADV
dpc-4148	64	2	,	,	PUNCT
dpc-4148	64	3	blood	blood	NOUN
dpc-4148	64	4	samples	sample	NOUN
dpc-4148	64	5	were	be	AUX
dpc-4148	64	6	studied	study	VERB
dpc-4148	64	7	by	by	ADP
dpc-4148	64	8	elisa	elisa	NOUN
dpc-4148	64	9	method	method	NOUN
dpc-4148	64	10	and	and	CCONJ
dpc-4148	64	11	tlr	tlr	PROPN
dpc-4148	64	12	by	by	ADP
dpc-4148	64	13	rt	rt	PROPN
dpc-4148	64	14	-	-	PUNCT
dpc-4148	64	15	pcr	pcr	ADJ
dpc-4148	64	16	method	method	NOUN
dpc-4148	64	17	.	.	PUNCT
dpc-4148	65	1	serum	serum	NOUN
dpc-4148	65	2	levels	level	NOUN
dpc-4148	65	3	of	of	ADP
dpc-4148	65	4	cytokines	cytokine	NOUN
dpc-4148	65	5	and	and	CCONJ
dpc-4148	65	6	gfs	gfs	PROPN
dpc-4148	65	7	il-6	il-6	PROPN
dpc-4148	65	8	,	,	PUNCT
dpc-4148	65	9	fgf	fgf	PROPN
dpc-4148	65	10	,	,	PUNCT
dpc-4148	65	11	tgf	tgf	PROPN
dpc-4148	65	12	-	-	PUNCT
dpc-4148	65	13	β1	β1	PROPN
dpc-4148	65	14	,	,	PUNCT
dpc-4148	65	15	and	and	CCONJ
dpc-4148	65	16	vegf	vegf	PROPN
dpc-4148	65	17	were	be	AUX
dpc-4148	65	18	chosen	choose	VERB
dpc-4148	65	19	because	because	SCONJ
dpc-4148	65	20	they	they	PRON
dpc-4148	65	21	have	have	AUX
dpc-4148	65	22	been	be	AUX
dpc-4148	65	23	proven	prove	VERB
dpc-4148	65	24	to	to	PART
dpc-4148	65	25	play	play	VERB
dpc-4148	65	26	an	an	DET
dpc-4148	65	27	important	important	ADJ
dpc-4148	65	28	role	role	NOUN
dpc-4148	65	29	in	in	ADP
dpc-4148	65	30	pathogenesis	pathogenesis	NOUN
dpc-4148	65	31	[	[	X
dpc-4148	65	32	19	19	NUM
dpc-4148	65	33	]	]	PUNCT
dpc-4148	65	34	.	.	PUNCT
dpc-4148	66	1	although	although	SCONJ
dpc-4148	66	2	there	there	PRON
dpc-4148	66	3	are	be	VERB
dpc-4148	66	4	conflicting	conflicting	ADJ
dpc-4148	66	5	results	result	NOUN
dpc-4148	66	6	about	about	ADP
dpc-4148	66	7	the	the	DET
dpc-4148	66	8	role	role	NOUN
dpc-4148	66	9	of	of	ADP
dpc-4148	66	10	il-17a	il-17a	PROPN
dpc-4148	66	11	in	in	ADP
dpc-4148	66	12	morphea	morphea	PROPN
dpc-4148	66	13	,	,	PUNCT
dpc-4148	66	14	we	we	PRON
dpc-4148	66	15	included	include	VERB
dpc-4148	66	16	it	it	PRON
dpc-4148	66	17	in	in	ADP
dpc-4148	66	18	our	our	PRON
dpc-4148	66	19	analysis	analysis	NOUN
dpc-4148	66	20	to	to	PART
dpc-4148	66	21	confirm	confirm	VERB
dpc-4148	66	22	these	these	DET
dpc-4148	66	23	results	result	NOUN
dpc-4148	66	24	and	and	CCONJ
dpc-4148	66	25	because	because	SCONJ
dpc-4148	66	26	of	of	ADP
dpc-4148	66	27	its	its	PRON
dpc-4148	66	28	popularity	popularity	NOUN
dpc-4148	66	29	in	in	ADP
dpc-4148	66	30	recent	recent	ADJ
dpc-4148	66	31	years	year	NOUN
dpc-4148	66	32	[	[	X
dpc-4148	66	33	20,21	20,21	NUM
dpc-4148	66	34	]	]	PUNCT
dpc-4148	66	35	.	.	PUNCT
dpc-4148	67	1	the	the	DET
dpc-4148	67	2	whole	whole	ADJ
dpc-4148	67	3	blood	blood	NOUN
dpc-4148	67	4	samples	sample	NOUN
dpc-4148	67	5	collected	collect	VERB
dpc-4148	67	6	using	use	VERB
dpc-4148	67	7	vacuum	vacuum	NOUN
dpc-4148	67	8	tubes	tube	NOUN
dpc-4148	67	9	from	from	ADP
dpc-4148	67	10	healthy	healthy	ADJ
dpc-4148	67	11	individuals	individual	NOUN
dpc-4148	67	12	and	and	CCONJ
dpc-4148	67	13	morphea	morphea	NOUN
dpc-4148	67	14	patients	patient	NOUN
dpc-4148	67	15	were	be	AUX
dpc-4148	67	16	centrifugated	centrifugate	VERB
dpc-4148	67	17	at	at	ADP
dpc-4148	67	18	3000	3000	NUM
dpc-4148	67	19	xg	xg	NOUN
dpc-4148	67	20	,	,	PUNCT
dpc-4148	67	21	10	10	NUM
dpc-4148	67	22	min	min	NOUN
dpc-4148	67	23	for	for	ADP
dpc-4148	67	24	serum	serum	NOUN
dpc-4148	67	25	separation	separation	NOUN
dpc-4148	67	26	.	.	PUNCT
dpc-4148	68	1	the	the	DET
dpc-4148	68	2	serum	serum	NOUN
dpc-4148	68	3	samples	sample	NOUN
dpc-4148	68	4	were	be	AUX
dpc-4148	68	5	transferred	transfer	VERB
dpc-4148	68	6	into	into	ADP
dpc-4148	68	7	sterile	sterile	ADJ
dpc-4148	68	8	1.5	1.5	NUM
dpc-4148	68	9	ml	ml	NOUN
dpc-4148	68	10	microcentrifuge	microcentrifuge	ADJ
dpc-4148	68	11	tubes	tube	NOUN
dpc-4148	68	12	and	and	CCONJ
dpc-4148	68	13	stored	store	VERB
dpc-4148	68	14	at	at	ADP
dpc-4148	68	15	-80	-80	NOUN
dpc-4148	68	16	°	°	ADP
dpc-4148	68	17	c	c	NOUN
dpc-4148	68	18	until	until	ADP
dpc-4148	68	19	elisa	elisa	NOUN
dpc-4148	68	20	analysis	analysis	NOUN
dpc-4148	68	21	.	.	PUNCT
dpc-4148	69	1	the	the	DET
dpc-4148	69	2	serum	serum	NOUN
dpc-4148	69	3	levels	level	NOUN
dpc-4148	69	4	of	of	ADP
dpc-4148	69	5	il-6	il-6	NOUN
dpc-4148	69	6	,	,	PUNCT
dpc-4148	69	7	il-17a	il-17a	PROPN
dpc-4148	69	8	,	,	PUNCT
dpc-4148	69	9	fgf	fgf	PROPN
dpc-4148	69	10	,	,	PUNCT
dpc-4148	69	11	tgf	tgf	PROPN
dpc-4148	69	12	-	-	PUNCT
dpc-4148	69	13	β1	β1	PROPN
dpc-4148	69	14	,	,	PUNCT
dpc-4148	69	15	and	and	CCONJ
dpc-4148	69	16	vegf	vegf	PROPN
dpc-4148	69	17	were	be	AUX
dpc-4148	69	18	detected	detect	VERB
dpc-4148	69	19	by	by	ADP
dpc-4148	69	20	elisa	elisa	NOUN
dpc-4148	69	21	kit	kit	NOUN
dpc-4148	69	22	for	for	ADP
dpc-4148	69	23	each	each	DET
dpc-4148	69	24	parameter	parameter	NOUN
dpc-4148	69	25	(	(	PUNCT
dpc-4148	69	26	bt	bt	NOUN
dpc-4148	69	27	lab	lab	PROPN
dpc-4148	69	28	,	,	PUNCT
dpc-4148	69	29	shanghai	shanghai	PROPN
dpc-4148	69	30	,	,	PUNCT
dpc-4148	69	31	china	china	PROPN
dpc-4148	69	32	)	)	PUNCT
dpc-4148	69	33	.	.	PUNCT
dpc-4148	70	1	kit	kit	NOUN
dpc-4148	70	2	sensitivity	sensitivity	NOUN
dpc-4148	70	3	values	value	NOUN
dpc-4148	70	4	were	be	AUX
dpc-4148	70	5	1.03	1.03	NUM
dpc-4148	70	6	ng	ng	PROPN
dpc-4148	70	7	/	/	SYM
dpc-4148	70	8	l	l	PROPN
dpc-4148	70	9	,	,	PUNCT
dpc-4148	70	10	2.38	2.38	PROPN
dpc-4148	70	11	ng	ng	PROPN
dpc-4148	70	12	/	/	SYM
dpc-4148	70	13	l	l	PROPN
dpc-4148	70	14	,	,	PUNCT
dpc-4148	70	15	9,85	9,85	PROPN
dpc-4148	70	16	ng	ng	PROPN
dpc-4148	70	17	/	/	SYM
dpc-4148	70	18	l	l	PROPN
dpc-4148	70	19	,	,	PUNCT
dpc-4148	70	20	5.11	5.11	NUM
dpc-4148	70	21	ng	ng	PROPN
dpc-4148	70	22	/	/	SYM
dpc-4148	70	23	l	l	PROPN
dpc-4148	70	24	,	,	PUNCT
dpc-4148	70	25	and	and	CCONJ
dpc-4148	70	26	10.42	10.42	NUM
dpc-4148	70	27	ng	ng	PROPN
dpc-4148	70	28	/	/	SYM
dpc-4148	70	29	l	l	PROPN
dpc-4148	70	30	for	for	ADP
dpc-4148	70	31	il6	il6	NOUN
dpc-4148	70	32	,	,	PUNCT
dpc-4148	70	33	il-7a	il-7a	PROPN
dpc-4148	70	34	,	,	PUNCT
dpc-4148	70	35	fgf	fgf	PROPN
dpc-4148	70	36	,	,	PUNCT
dpc-4148	70	37	tgf	tgf	PROPN
dpc-4148	70	38	-	-	PUNCT
dpc-4148	70	39	β1	β1	PROPN
dpc-4148	70	40	,	,	PUNCT
dpc-4148	70	41	and	and	CCONJ
dpc-4148	70	42	vegf	vegf	PROPN
dpc-4148	70	43	,	,	PUNCT
dpc-4148	70	44	respectively	respectively	ADV
dpc-4148	70	45	.	.	PUNCT
dpc-4148	71	1	this	this	DET
dpc-4148	71	2	assay	assay	NOUN
dpc-4148	71	3	was	be	AUX
dpc-4148	71	4	based	base	VERB
dpc-4148	71	5	on	on	ADP
dpc-4148	71	6	the	the	DET
dpc-4148	71	7	biotin	biotin	NOUN
dpc-4148	71	8	double	double	ADJ
dpc-4148	71	9	-	-	PUNCT
dpc-4148	71	10	antibody	antibody	NOUN
dpc-4148	71	11	sandwich	sandwich	NOUN
dpc-4148	71	12	technology	technology	NOUN
dpc-4148	71	13	to	to	PART
dpc-4148	71	14	quantify	quantify	VERB
dpc-4148	71	15	specific	specific	ADJ
dpc-4148	71	16	il-6	il-6	NOUN
dpc-4148	71	17	,	,	PUNCT
dpc-4148	71	18	il-17a	il-17a	PROPN
dpc-4148	71	19	,	,	PUNCT
dpc-4148	71	20	fgf	fgf	PROPN
dpc-4148	71	21	,	,	PUNCT
dpc-4148	71	22	tgf	tgf	PROPN
dpc-4148	71	23	-	-	PUNCT
dpc-4148	71	24	β1	β1	PROPN
dpc-4148	71	25	,	,	PUNCT
dpc-4148	71	26	and	and	CCONJ
dpc-4148	71	27	vegf	vegf	PROPN
dpc-4148	71	28	antigens	antigen	NOUN
dpc-4148	71	29	.	.	PUNCT
dpc-4148	72	1	briefly	briefly	ADV
dpc-4148	72	2	,	,	PUNCT
dpc-4148	72	3	serum	serum	NOUN
dpc-4148	72	4	samples	sample	NOUN
dpc-4148	72	5	were	be	AUX
dpc-4148	72	6	diluted	dilute	VERB
dpc-4148	72	7	as	as	ADP
dpc-4148	72	8	1:10	1:10	NUM
dpc-4148	72	9	just	just	ADV
dpc-4148	72	10	before	before	ADP
dpc-4148	72	11	analysis	analysis	NOUN
dpc-4148	72	12	,	,	PUNCT
dpc-4148	72	13	and	and	CCONJ
dpc-4148	72	14	standards	standard	NOUN
dpc-4148	72	15	were	be	AUX
dpc-4148	72	16	added	add	VERB
dpc-4148	72	17	to	to	ADP
dpc-4148	72	18	the	the	DET
dpc-4148	72	19	respective	respective	ADJ
dpc-4148	72	20	well	well	INTJ
dpc-4148	72	21	pre	pre	ADJ
dpc-4148	72	22	-	-	VERB
dpc-4148	72	23	coated	coated	ADJ
dpc-4148	72	24	with	with	ADP
dpc-4148	72	25	human	human	NOUN
dpc-4148	72	26	-	-	PUNCT
dpc-4148	72	27	specific	specific	ADJ
dpc-4148	72	28	primary	primary	ADJ
dpc-4148	72	29	antibody	antibody	NOUN
dpc-4148	72	30	.	.	PUNCT
dpc-4148	73	1	biotinylated	biotinylate	VERB
dpc-4148	73	2	,	,	PUNCT
dpc-4148	73	3	another	another	DET
dpc-4148	73	4	specific	specific	ADJ
dpc-4148	73	5	primary	primary	ADJ
dpc-4148	73	6	antibody	antibody	NOUN
dpc-4148	73	7	,	,	PUNCT
dpc-4148	73	8	was	be	AUX
dpc-4148	73	9	added	add	VERB
dpc-4148	73	10	to	to	PART
dpc-4148	73	11	bind	bind	VERB
dpc-4148	73	12	to	to	ADP
dpc-4148	73	13	specific	specific	ADJ
dpc-4148	73	14	antigen	antigen	NOUN
dpc-4148	73	15	in	in	ADP
dpc-4148	73	16	the	the	DET
dpc-4148	73	17	sample	sample	NOUN
dpc-4148	73	18	.	.	PUNCT
dpc-4148	74	1	followed	follow	VERB
dpc-4148	74	2	by	by	ADP
dpc-4148	74	3	first	first	ADV
dpc-4148	74	4	adding	add	VERB
dpc-4148	74	5	streptavidin	streptavidin	PROPN
dpc-4148	74	6	-	-	PROPN
dpc-4148	74	7	hrp	hrp	PROPN
dpc-4148	74	8	and	and	CCONJ
dpc-4148	74	9	then	then	ADV
dpc-4148	74	10	biotinylated	biotinylate	VERB
dpc-4148	74	11	secondary	secondary	ADJ
dpc-4148	74	12	antibody	antibody	NOUN
dpc-4148	74	13	,	,	PUNCT
dpc-4148	74	14	the	the	DET
dpc-4148	74	15	samples	sample	NOUN
dpc-4148	74	16	were	be	AUX
dpc-4148	74	17	incubated	incubate	VERB
dpc-4148	74	18	with	with	ADP
dpc-4148	74	19	substrate	substrate	NOUN
dpc-4148	74	20	solution	solution	NOUN
dpc-4148	74	21	for	for	ADP
dpc-4148	74	22	color	color	NOUN
dpc-4148	74	23	develops	develop	VERB
dpc-4148	74	24	in	in	ADP
dpc-4148	74	25	proportion	proportion	NOUN
dpc-4148	74	26	to	to	ADP
dpc-4148	74	27	the	the	DET
dpc-4148	74	28	amount	amount	NOUN
dpc-4148	74	29	of	of	ADP
dpc-4148	74	30	specific	specific	ADJ
dpc-4148	74	31	antigen	antigen	NOUN
dpc-4148	74	32	.	.	PUNCT
dpc-4148	75	1	the	the	DET
dpc-4148	75	2	reaction	reaction	NOUN
dpc-4148	75	3	was	be	AUX
dpc-4148	75	4	terminated	terminate	VERB
dpc-4148	75	5	by	by	ADP
dpc-4148	75	6	adding	add	VERB
dpc-4148	75	7	acidic	acidic	ADJ
dpc-4148	75	8	stop	stop	NOUN
dpc-4148	75	9	solution	solution	NOUN
dpc-4148	75	10	,	,	PUNCT
dpc-4148	75	11	and	and	CCONJ
dpc-4148	75	12	absorbance	absorbance	NOUN
dpc-4148	75	13	was	be	AUX
dpc-4148	75	14	measured	measure	VERB
dpc-4148	75	15	at	at	ADP
dpc-4148	75	16	450	450	NUM
dpc-4148	75	17	nm	nm	NOUN
dpc-4148	75	18	.	.	PUNCT
dpc-4148	76	1	the	the	DET
dpc-4148	76	2	serum	serum	NOUN
dpc-4148	76	3	levels	level	NOUN
dpc-4148	76	4	of	of	ADP
dpc-4148	76	5	il-6	il-6	NOUN
dpc-4148	76	6	,	,	PUNCT
dpc-4148	76	7	il-17a	il-17a	PROPN
dpc-4148	76	8	,	,	PUNCT
dpc-4148	76	9	fgf	fgf	PROPN
dpc-4148	76	10	,	,	PUNCT
dpc-4148	76	11	tgf	tgf	PROPN
dpc-4148	76	12	-	-	PUNCT
dpc-4148	76	13	β1	β1	PROPN
dpc-4148	76	14	,	,	PUNCT
dpc-4148	76	15	and	and	CCONJ
dpc-4148	76	16	vegf	vegf	PROPN
dpc-4148	76	17	were	be	AUX
dpc-4148	76	18	calculated	calculate	VERB
dpc-4148	76	19	according	accord	VERB
dpc-4148	76	20	to	to	ADP
dpc-4148	76	21	the	the	DET
dpc-4148	76	22	specific	specific	ADJ
dpc-4148	76	23	standard	standard	ADJ
dpc-4148	76	24	curve	curve	NOUN
dpc-4148	76	25	for	for	ADP
dpc-4148	76	26	each	each	DET
dpc-4148	76	27	parameter	parameter	NOUN
dpc-4148	76	28	.	.	PUNCT
dpc-4148	77	1	the	the	DET
dpc-4148	77	2	results	result	NOUN
dpc-4148	77	3	of	of	ADP
dpc-4148	77	4	three	three	NUM
dpc-4148	77	5	independent	independent	ADJ
dpc-4148	77	6	experiments	experiment	NOUN
dpc-4148	77	7	for	for	ADP
dpc-4148	77	8	each	each	DET
dpc-4148	77	9	parameter	parameter	NOUN
dpc-4148	77	10	were	be	AUX
dpc-4148	77	11	triplicated	triplicate	VERB
dpc-4148	77	12	and	and	CCONJ
dpc-4148	77	13	are	be	AUX
dpc-4148	77	14	expressed	express	VERB
dpc-4148	77	15	as	as	ADP
dpc-4148	77	16	mean	mean	NOUN
dpc-4148	77	17	±	±	NUM
dpc-4148	77	18	standard	standard	ADJ
dpc-4148	77	19	error	error	NOUN
dpc-4148	77	20	of	of	ADP
dpc-4148	77	21	mean	mean	NOUN
dpc-4148	77	22	(	(	PUNCT
dpc-4148	77	23	sem	sem	NOUN
dpc-4148	77	24	)	)	PUNCT
dpc-4148	77	25	.	.	PUNCT
dpc-4148	78	1	real	real	ADJ
dpc-4148	78	2	time	time	NOUN
dpc-4148	78	3	-	-	PUNCT
dpc-4148	78	4	pcr	pcr	ADJ
dpc-4148	78	5	(	(	PUNCT
dpc-4148	78	6	qpcr	qpcr	ADV
dpc-4148	78	7	)	)	PUNCT
dpc-4148	78	8	in	in	ADP
dpc-4148	78	9	this	this	DET
dpc-4148	78	10	study	study	NOUN
dpc-4148	78	11	,	,	PUNCT
dpc-4148	78	12	we	we	PRON
dpc-4148	78	13	investigated	investigate	VERB
dpc-4148	78	14	the	the	DET
dpc-4148	78	15	mrna	mrna	NOUN
dpc-4148	78	16	expression	expression	NOUN
dpc-4148	78	17	changes	change	NOUN
dpc-4148	78	18	of	of	ADP
dpc-4148	78	19	tlrs	tlrs	NOUN
dpc-4148	78	20	in	in	ADP
dpc-4148	78	21	morphea	morphea	PROPN
dpc-4148	78	22	patient	patient	NOUN
dpc-4148	78	23	samples	sample	NOUN
dpc-4148	78	24	compared	compare	VERB
dpc-4148	78	25	to	to	ADP
dpc-4148	78	26	controls	control	NOUN
dpc-4148	78	27	by	by	ADP
dpc-4148	78	28	rt	rt	NOUN
dpc-4148	78	29	-	-	PUNCT
dpc-4148	78	30	pcr	pcr	NOUN
dpc-4148	78	31	.	.	PUNCT
dpc-4148	79	1	based	base	VERB
dpc-4148	79	2	on	on	ADP
dpc-4148	79	3	this	this	DET
dpc-4148	79	4	purpose	purpose	NOUN
dpc-4148	79	5	,	,	PUNCT
dpc-4148	79	6	mrna	mrna	NOUN
dpc-4148	79	7	expression	expression	NOUN
dpc-4148	79	8	changes	change	NOUN
dpc-4148	79	9	of	of	ADP
dpc-4148	79	10	tlr1	tlr1	NOUN
dpc-4148	79	11	,	,	PUNCT
dpc-4148	79	12	2	2	NUM
dpc-4148	79	13	,	,	PUNCT
dpc-4148	79	14	3	3	NUM
dpc-4148	79	15	,	,	PUNCT
dpc-4148	79	16	4	4	NUM
dpc-4148	79	17	,	,	PUNCT
dpc-4148	79	18	5	5	NUM
dpc-4148	79	19	,	,	PUNCT
dpc-4148	79	20	6	6	NUM
dpc-4148	79	21	,	,	PUNCT
dpc-4148	79	22	7	7	NUM
dpc-4148	79	23	,	,	PUNCT
dpc-4148	79	24	8	8	NUM
dpc-4148	79	25	,	,	PUNCT
dpc-4148	79	26	9	9	NUM
dpc-4148	79	27	,	,	PUNCT
dpc-4148	79	28	and	and	CCONJ
dpc-4148	79	29	10	10	NUM
dpc-4148	79	30	genes	gene	NOUN
dpc-4148	79	31	involved	involve	VERB
dpc-4148	79	32	in	in	ADP
dpc-4148	79	33	pathways	pathway	NOUN
dpc-4148	79	34	associated	associate	VERB
dpc-4148	79	35	with	with	ADP
dpc-4148	79	36	tlrs	tlrs	PROPN
dpc-4148	79	37	(	(	PUNCT
dpc-4148	79	38	myd88	myd88	PROPN
dpc-4148	79	39	-	-	PUNCT
dpc-4148	79	40	dependent	dependent	ADJ
dpc-4148	79	41	and	and	CCONJ
dpc-4148	79	42	independent	independent	ADJ
dpc-4148	79	43	)	)	PUNCT
dpc-4148	79	44	and	and	CCONJ
dpc-4148	79	45	downstream	downstream	ADJ
dpc-4148	79	46	targets	target	NOUN
dpc-4148	79	47	were	be	AUX
dpc-4148	79	48	detected	detect	VERB
dpc-4148	79	49	.	.	PUNCT
dpc-4148	80	1	β	β	X
dpc-4148	80	2	-	-	PUNCT
dpc-4148	80	3	actin	actin	NOUN
dpc-4148	80	4	was	be	AUX
dpc-4148	80	5	used	use	VERB
dpc-4148	80	6	as	as	ADP
dpc-4148	80	7	housekeeping	housekeeping	NOUN
dpc-4148	80	8	for	for	ADP
dpc-4148	80	9	normalization	normalization	NOUN
dpc-4148	80	10	.	.	PUNCT
dpc-4148	81	1	the	the	DET
dpc-4148	81	2	reverse	reverse	NOUN
dpc-4148	81	3	and	and	CCONJ
dpc-4148	81	4	forward	forward	ADJ
dpc-4148	81	5	sequences	sequence	NOUN
dpc-4148	81	6	of	of	ADP
dpc-4148	81	7	the	the	DET
dpc-4148	81	8	genes	gene	NOUN
dpc-4148	81	9	are	be	AUX
dpc-4148	81	10	given	give	VERB
dpc-4148	81	11	in	in	ADP
dpc-4148	81	12	table	table	NOUN
dpc-4148	81	13	1	1	NUM
dpc-4148	81	14	.	.	PUNCT
dpc-4148	82	1	sequences	sequence	NOUN
dpc-4148	82	2	were	be	AUX
dpc-4148	82	3	designed	design	VERB
dpc-4148	82	4	using	use	VERB
dpc-4148	82	5	origene	origene	NOUN
dpc-4148	82	6	(	(	PUNCT
dpc-4148	82	7	https://www.origene	https://www.origene	NOUN
dpc-4148	82	8	.com/	.com/	ADJ
dpc-4148	82	9	)	)	PUNCT
dpc-4148	82	10	online	online	ADJ
dpc-4148	82	11	website	website	NOUN
dpc-4148	82	12	and	and	CCONJ
dpc-4148	82	13	blast	blast	NOUN
dpc-4148	82	14	(	(	PUNCT
dpc-4148	82	15	basic	basic	ADJ
dpc-4148	82	16	local	local	ADJ
dpc-4148	82	17	alignment	alignment	NOUN
dpc-4148	82	18	search	search	NOUN
dpc-4148	82	19	tool	tool	NOUN
dpc-4148	82	20	)	)	PUNCT
dpc-4148	82	21	(	(	PUNCT
dpc-4148	82	22	https://blast.ncbi.nlm.nih.gov/blast.cgi	https://blast.ncbi.nlm.nih.gov/blast.cgi	ADJ
dpc-4148	82	23	)	)	PUNCT
dpc-4148	82	24	software	software	NOUN
dpc-4148	82	25	.	.	PUNCT
dpc-4148	83	1	reaction	reaction	NOUN
dpc-4148	83	2	conditions	condition	NOUN
dpc-4148	83	3	in	in	ADP
dpc-4148	83	4	96	96	NUM
dpc-4148	83	5	-	-	PUNCT
dpc-4148	83	6	well	well	NOUN
dpc-4148	83	7	plate	plate	NOUN
dpc-4148	83	8	with	with	ADP
dpc-4148	83	9	5.5	5.5	NUM
dpc-4148	83	10	μl	μl	ADV
dpc-4148	83	11	sybr	sybr	X
dpc-4148	83	12	green	green	ADJ
dpc-4148	83	13	master	master	NOUN
dpc-4148	83	14	mix	mix	NOUN
dpc-4148	83	15	(	(	PUNCT
dpc-4148	83	16	abt	abt	INTJ
dpc-4148	83	17	2x	2x	NUM
dpc-4148	83	18	qpcr	qpcr	ADV
dpc-4148	83	19	sybr	sybr	VERB
dpc-4148	83	20	green	green	ADJ
dpc-4148	83	21	master	master	NOUN
dpc-4148	83	22	mix	mix	PROPN
dpc-4148	83	23	)	)	PUNCT
dpc-4148	83	24	,	,	PUNCT
dpc-4148	83	25	6.5	6.5	NUM
dpc-4148	83	26	μl	μl	ADP
dpc-4148	83	27	nuclease	nuclease	NOUN
dpc-4148	83	28	-	-	PUNCT
dpc-4148	83	29	free	free	ADJ
dpc-4148	83	30	water	water	NOUN
dpc-4148	83	31	,	,	PUNCT
dpc-4148	83	32	2	2	NUM
dpc-4148	83	33	μl	μl	PRON
dpc-4148	83	34	(	(	PUNCT
dpc-4148	83	35	1	1	NUM
dpc-4148	83	36	reverse	reverse	VERB
dpc-4148	83	37	+	+	CCONJ
dpc-4148	83	38	1	1	NUM
dpc-4148	83	39	forward	forward	ADJ
dpc-4148	83	40	)	)	PUNCT
dpc-4148	83	41	primer	primer	NOUN
dpc-4148	83	42	,	,	PUNCT
dpc-4148	83	43	and	and	CCONJ
dpc-4148	83	44	1	1	NUM
dpc-4148	83	45	μl	μl	ADP
dpc-4148	83	46	cdna	cdna	PROPN
dpc-4148	83	47	per	per	ADV
dpc-4148	83	48	well	well	ADV
dpc-4148	83	49	was	be	AUX
dpc-4148	83	50	set	set	VERB
dpc-4148	83	51	up	up	ADP
dpc-4148	83	52	,	,	PUNCT
dpc-4148	83	53	and	and	CCONJ
dpc-4148	83	54	the	the	DET
dpc-4148	83	55	surface	surface	NOUN
dpc-4148	83	56	of	of	ADP
dpc-4148	83	57	the	the	DET
dpc-4148	83	58	plate	plate	NOUN
dpc-4148	83	59	was	be	AUX
dpc-4148	83	60	sealed	seal	VERB
dpc-4148	83	61	with	with	ADP
dpc-4148	83	62	a	a	DET
dpc-4148	83	63	clear	clear	ADJ
dpc-4148	83	64	adhesive	adhesive	ADJ
dpc-4148	83	65	label	label	NOUN
dpc-4148	83	66	(	(	PUNCT
dpc-4148	83	67	applied	apply	VERB
dpc-4148	83	68	biosystemstm	biosystemstm	ADJ
dpc-4148	83	69	96	96	NUM
dpc-4148	83	70	-	-	PUNCT
dpc-4148	83	71	well	well	NOUN
dpc-4148	83	72	reaction	reaction	NOUN
dpc-4148	83	73	plate	plate	NOUN
dpc-4148	83	74	seal	seal	NOUN
dpc-4148	83	75	)	)	PUNCT
dpc-4148	83	76	.	.	PUNCT
dpc-4148	84	1	the	the	DET
dpc-4148	84	2	plate	plate	NOUN
dpc-4148	84	3	loaded	load	VERB
dpc-4148	84	4	into	into	ADP
dpc-4148	84	5	the	the	DET
dpc-4148	84	6	stepone	stepone	PROPN
dpc-4148	84	7	plus	plus	CCONJ
dpc-4148	84	8	rt	rt	ADJ
dpc-4148	84	9	-	-	PUNCT
dpc-4148	84	10	pcr	pcr	ADJ
dpc-4148	84	11	device	device	NOUN
dpc-4148	84	12	was	be	AUX
dpc-4148	84	13	amplified	amplify	VERB
dpc-4148	84	14	for	for	ADP
dpc-4148	84	15	40	40	NUM
dpc-4148	84	16	cycles	cycle	NOUN
dpc-4148	84	17	,	,	PUNCT
dpc-4148	84	18	5	5	NUM
dpc-4148	84	19	min	min	NOUN
dpc-4148	84	20	at	at	ADP
dpc-4148	84	21	95	95	NUM
dpc-4148	84	22	°	°	NOUN
dpc-4148	84	23	c	c	NOUN
dpc-4148	84	24	,	,	PUNCT
dpc-4148	84	25	and	and	CCONJ
dpc-4148	84	26	1	1	NUM
dpc-4148	84	27	min	min	NOUN
dpc-4148	84	28	at	at	ADP
dpc-4148	84	29	60	60	NUM
dpc-4148	84	30	°	°	NOUN
dpc-4148	84	31	c	c	NOUN
dpc-4148	84	32	.	.	PUNCT
dpc-4148	85	1	statistical	statistical	ADJ
dpc-4148	85	2	analyses	analysis	NOUN
dpc-4148	85	3	spss	spss	PROPN
dpc-4148	85	4	(	(	PUNCT
dpc-4148	85	5	18.0.0.2	18.0.0.2	NUM
dpc-4148	85	6	;	;	PUNCT
dpc-4148	85	7	ibm	ibm	PROPN
dpc-4148	85	8	,	,	PUNCT
dpc-4148	85	9	armonk	armonk	PROPN
dpc-4148	85	10	,	,	PUNCT
dpc-4148	85	11	ny	ny	PROPN
dpc-4148	85	12	,	,	PUNCT
dpc-4148	85	13	usa	usa	PROPN
dpc-4148	85	14	)	)	PUNCT
dpc-4148	85	15	was	be	AUX
dpc-4148	85	16	used	use	VERB
dpc-4148	85	17	for	for	ADP
dpc-4148	85	18	the	the	DET
dpc-4148	85	19	analyses	analysis	NOUN
dpc-4148	85	20	.	.	PUNCT
dpc-4148	86	1	the	the	DET
dpc-4148	86	2	shapiro	shapiro	PROPN
dpc-4148	86	3	wilk	wilk	PROPN
dpc-4148	86	4	test	test	PROPN
dpc-4148	86	5	was	be	AUX
dpc-4148	86	6	used	use	VERB
dpc-4148	86	7	to	to	PART
dpc-4148	86	8	determine	determine	VERB
dpc-4148	86	9	whether	whether	SCONJ
dpc-4148	86	10	the	the	DET
dpc-4148	86	11	continuous	continuous	ADJ
dpc-4148	86	12	variables	variable	NOUN
dpc-4148	86	13	were	be	AUX
dpc-4148	86	14	normally	normally	ADV
dpc-4148	86	15	distributed	distribute	VERB
dpc-4148	86	16	.	.	PUNCT
dpc-4148	87	1	normally	normally	ADV
dpc-4148	87	2	distributed	distribute	VERB
dpc-4148	87	3	parameters	parameter	NOUN
dpc-4148	87	4	were	be	AUX
dpc-4148	87	5	compared	compare	VERB
dpc-4148	87	6	with	with	ADP
dpc-4148	87	7	student	student	NOUN
dpc-4148	87	8	’s	’s	PART
dpc-4148	87	9	t	t	PROPN
dpc-4148	87	10	test	test	NOUN
dpc-4148	87	11	and	and	CCONJ
dpc-4148	87	12	non	non	ADJ
dpc-4148	87	13	-	-	ADJ
dpc-4148	87	14	normally	normally	ADV
dpc-4148	87	15	distributed	distribute	VERB
dpc-4148	87	16	parameters	parameter	NOUN
dpc-4148	87	17	were	be	AUX
dpc-4148	87	18	compared	compare	VERB
dpc-4148	87	19	with	with	ADP
dpc-4148	87	20	mann	mann	PROPN
dpc-4148	87	21	-	-	PUNCT
dpc-4148	87	22	whitney	whitney	PROPN
dpc-4148	87	23	u	u	PROPN
dpc-4148	87	24	test	test	NOUN
dpc-4148	87	25	.	.	PUNCT
dpc-4148	88	1	the	the	DET
dpc-4148	88	2	relationship	relationship	NOUN
dpc-4148	88	3	between	between	ADP
dpc-4148	88	4	serum	serum	NOUN
dpc-4148	88	5	cytokine	cytokine	NOUN
dpc-4148	88	6	and	and	CCONJ
dpc-4148	88	7	factor	factor	NOUN
dpc-4148	88	8	levels	level	NOUN
dpc-4148	88	9	and	and	CCONJ
dpc-4148	88	10	other	other	ADJ
dpc-4148	88	11	variables	variable	NOUN
dpc-4148	88	12	was	be	AUX
dpc-4148	88	13	evaluated	evaluate	VERB
dpc-4148	88	14	by	by	ADP
dpc-4148	88	15	spearman	spearman	NOUN
dpc-4148	88	16	correlation	correlation	NOUN
dpc-4148	88	17	analysis	analysis	NOUN
dpc-4148	88	18	.	.	PUNCT
dpc-4148	89	1	in	in	ADP
dpc-4148	89	2	addition	addition	NOUN
dpc-4148	89	3	,	,	PUNCT
dpc-4148	89	4	the	the	DET
dpc-4148	89	5	relationship	relationship	NOUN
dpc-4148	89	6	between	between	ADP
dpc-4148	89	7	these	these	DET
dpc-4148	89	8	and	and	CCONJ
dpc-4148	89	9	disease	disease	NOUN
dpc-4148	89	10	severity	severity	NOUN
dpc-4148	89	11	scores	score	NOUN
dpc-4148	89	12	was	be	AUX
dpc-4148	89	13	evaluated	evaluate	VERB
dpc-4148	89	14	with	with	ADP
dpc-4148	89	15	the	the	DET
dpc-4148	89	16	kruskal	kruskal	PROPN
dpc-4148	89	17	-	-	PUNCT
dpc-4148	89	18	wallis	wallis	PROPN
dpc-4148	89	19	test	test	NOUN
dpc-4148	89	20	.	.	PUNCT
dpc-4148	90	1	values	value	NOUN
dpc-4148	90	2	with	with	ADP
dpc-4148	90	3	p	p	NOUN
dpc-4148	90	4	<	<	NOUN
dpc-4148	90	5	0.05	0.05	NUM
dpc-4148	90	6	were	be	AUX
dpc-4148	90	7	considered	consider	VERB
dpc-4148	90	8	statistically	statistically	ADV
dpc-4148	90	9	significant	significant	ADJ
dpc-4148	90	10	.	.	PUNCT
dpc-4148	91	1	results	result	VERB
dpc-4148	91	2	fifteen	fifteen	NUM
dpc-4148	91	3	patients	patient	NOUN
dpc-4148	91	4	with	with	ADP
dpc-4148	91	5	morphea	morphea	PROPN
dpc-4148	91	6	(	(	PUNCT
dpc-4148	91	7	12	12	NUM
dpc-4148	91	8	females	female	NOUN
dpc-4148	91	9	,	,	PUNCT
dpc-4148	91	10	3	3	NUM
dpc-4148	91	11	males	male	NOUN
dpc-4148	91	12	)	)	PUNCT
dpc-4148	91	13	and	and	CCONJ
dpc-4148	91	14	11	11	NUM
dpc-4148	91	15	healthy	healthy	ADJ
dpc-4148	91	16	controls	control	NOUN
dpc-4148	91	17	(	(	PUNCT
dpc-4148	91	18	9	9	NUM
dpc-4148	91	19	females	female	NOUN
dpc-4148	91	20	,	,	PUNCT
dpc-4148	91	21	2	2	NUM
dpc-4148	91	22	males	male	NOUN
dpc-4148	91	23	)	)	PUNCT
dpc-4148	91	24	were	be	AUX
dpc-4148	91	25	included	include	VERB
dpc-4148	91	26	in	in	ADP
dpc-4148	91	27	our	our	PRON
dpc-4148	91	28	study	study	NOUN
dpc-4148	91	29	.	.	PUNCT
dpc-4148	92	1	while	while	SCONJ
dpc-4148	92	2	the	the	DET
dpc-4148	92	3	mean	mean	ADJ
dpc-4148	92	4	age	age	NOUN
dpc-4148	92	5	of	of	ADP
dpc-4148	92	6	the	the	DET
dpc-4148	92	7	patients	patient	NOUN
dpc-4148	92	8	was	be	AUX
dpc-4148	92	9	44.43	44.43	NUM
dpc-4148	92	10	years	year	NOUN
dpc-4148	92	11	,	,	PUNCT
dpc-4148	92	12	the	the	DET
dpc-4148	92	13	mean	mean	ADJ
dpc-4148	92	14	age	age	NOUN
dpc-4148	92	15	in	in	ADP
dpc-4148	92	16	the	the	DET
dpc-4148	92	17	control	control	NOUN
dpc-4148	92	18	group	group	NOUN
dpc-4148	92	19	was	be	AUX
dpc-4148	92	20	43.91	43.91	NUM
dpc-4148	92	21	years	year	NOUN
dpc-4148	92	22	.	.	PUNCT
dpc-4148	93	1	no	no	DET
dpc-4148	93	2	significant	significant	ADJ
dpc-4148	93	3	difference	difference	NOUN
dpc-4148	93	4	was	be	AUX
dpc-4148	93	5	seen	see	VERB
dpc-4148	93	6	in	in	ADP
dpc-4148	93	7	terms	term	NOUN
dpc-4148	93	8	of	of	ADP
dpc-4148	93	9	age	age	NOUN
dpc-4148	93	10	and	and	CCONJ
dpc-4148	93	11	sex	sex	NOUN
dpc-4148	93	12	between	between	ADP
dpc-4148	93	13	the	the	DET
dpc-4148	93	14	two	two	NUM
dpc-4148	93	15	groups	group	NOUN
dpc-4148	93	16	(	(	PUNCT
dpc-4148	93	17	p>0.05	p>0.05	PROPN
dpc-4148	93	18	)	)	PUNCT
dpc-4148	93	19	.	.	PUNCT
dpc-4148	94	1	eight	eight	NUM
dpc-4148	94	2	of	of	ADP
dpc-4148	94	3	the	the	DET
dpc-4148	94	4	patients	patient	NOUN
dpc-4148	94	5	(	(	PUNCT
dpc-4148	94	6	53.3	53.3	NUM
dpc-4148	94	7	%	%	NOUN
dpc-4148	94	8	)	)	PUNCT
dpc-4148	94	9	had	have	AUX
dpc-4148	94	10	generalized	generalize	VERB
dpc-4148	94	11	plaque	plaque	NOUN
dpc-4148	94	12	morphea	morphea	NOUN
dpc-4148	94	13	,	,	PUNCT
dpc-4148	94	14	6	6	NUM
dpc-4148	94	15	(	(	PUNCT
dpc-4148	94	16	40	40	NUM
dpc-4148	94	17	%	%	NOUN
dpc-4148	94	18	)	)	PUNCT
dpc-4148	94	19	had	have	VERB
dpc-4148	94	20	localized	localize	VERB
dpc-4148	94	21	plaque	plaque	NOUN
dpc-4148	94	22	morphea	morphea	NOUN
dpc-4148	94	23	,	,	PUNCT
dpc-4148	94	24	and	and	CCONJ
dpc-4148	94	25	1	1	NUM
dpc-4148	94	26	(	(	PUNCT
dpc-4148	94	27	6.7	6.7	NUM
dpc-4148	94	28	%	%	NOUN
dpc-4148	94	29	)	)	PUNCT
dpc-4148	94	30	had	have	VERB
dpc-4148	94	31	pansclerotic	pansclerotic	ADJ
dpc-4148	94	32	(	(	PUNCT
dpc-4148	94	33	deep	deep	ADJ
dpc-4148	94	34	)	)	PUNCT
dpc-4148	94	35	morphea	morphea	PROPN
dpc-4148	94	36	.	.	PUNCT
dpc-4148	95	1	the	the	DET
dpc-4148	95	2	mean	mean	ADJ
dpc-4148	95	3	disease	disease	NOUN
dpc-4148	95	4	duration	duration	NOUN
dpc-4148	95	5	was	be	AUX
dpc-4148	95	6	4.71	4.71	NUM
dpc-4148	95	7	(	(	PUNCT
dpc-4148	95	8	0.5	0.5	NUM
dpc-4148	95	9	-	-	SYM
dpc-4148	95	10	12	12	NUM
dpc-4148	95	11	)	)	PUNCT
dpc-4148	95	12	years	year	NOUN
dpc-4148	95	13	.	.	PUNCT
dpc-4148	96	1	the	the	DET
dpc-4148	96	2	most	most	ADV
dpc-4148	96	3	common	common	ADJ
dpc-4148	96	4	site	site	NOUN
dpc-4148	96	5	of	of	ADP
dpc-4148	96	6	involvement	involvement	NOUN
dpc-4148	96	7	was	be	AUX
dpc-4148	96	8	the	the	DET
dpc-4148	96	9	trunk	trunk	NOUN
dpc-4148	96	10	(	(	PUNCT
dpc-4148	96	11	73.3	73.3	NUM
dpc-4148	96	12	%	%	NOUN
dpc-4148	96	13	)	)	PUNCT
dpc-4148	96	14	.	.	PUNCT
dpc-4148	97	1	among	among	ADP
dpc-4148	97	2	the	the	DET
dpc-4148	97	3	severity	severity	NOUN
dpc-4148	97	4	index	index	NOUN
dpc-4148	97	5	scores	score	NOUN
dpc-4148	97	6	of	of	ADP
dpc-4148	97	7	the	the	DET
dpc-4148	97	8	patients	patient	NOUN
dpc-4148	97	9	,	,	PUNCT
dpc-4148	97	10	the	the	DET
dpc-4148	97	11	mean	mean	ADJ
dpc-4148	97	12	mlossi	mlossi	NOUN
dpc-4148	97	13	score	score	NOUN
dpc-4148	97	14	was	be	AUX
dpc-4148	97	15	15.375	15.375	NUM
dpc-4148	97	16	,	,	PUNCT
dpc-4148	97	17	while	while	SCONJ
dpc-4148	97	18	the	the	DET
dpc-4148	97	19	mean	mean	NOUN
dpc-4148	97	20	losdi	losdi	NOUN
dpc-4148	97	21	score	score	NOUN
dpc-4148	97	22	was	be	AUX
dpc-4148	97	23	16.875	16.875	NUM
dpc-4148	97	24	.	.	PUNCT
dpc-4148	98	1	itching	itching	NOUN
dpc-4148	98	2	was	be	AUX
dpc-4148	98	3	the	the	DET
dpc-4148	98	4	most	most	ADV
dpc-4148	98	5	common	common	ADJ
dpc-4148	98	6	symptom	symptom	NOUN
dpc-4148	98	7	in	in	ADP
dpc-4148	98	8	patients	patient	NOUN
dpc-4148	98	9	(	(	PUNCT
dpc-4148	98	10	40	40	NUM
dpc-4148	98	11	%	%	NOUN
dpc-4148	98	12	)	)	PUNCT
dpc-4148	98	13	.	.	PUNCT
dpc-4148	99	1	while	while	SCONJ
dpc-4148	99	2	the	the	DET
dpc-4148	99	3	disease	disease	NOUN
dpc-4148	99	4	of	of	ADP
dpc-4148	99	5	10	10	NUM
dpc-4148	99	6	patients	patient	NOUN
dpc-4148	99	7	(	(	PUNCT
dpc-4148	99	8	66.6	66.6	NUM
dpc-4148	99	9	%	%	NOUN
dpc-4148	99	10	)	)	PUNCT
dpc-4148	99	11	was	be	AUX
dpc-4148	99	12	stable	stable	ADJ
dpc-4148	99	13	for	for	ADP
dpc-4148	99	14	the	the	DET
dpc-4148	99	15	preceding	precede	VERB
dpc-4148	99	16	six	six	NUM
dpc-4148	99	17	months	month	NOUN
dpc-4148	99	18	,	,	PUNCT
dpc-4148	99	19	the	the	DET
dpc-4148	99	20	disease	disease	NOUN
dpc-4148	99	21	of	of	ADP
dpc-4148	99	22	five	five	NUM
dpc-4148	99	23	patients	patient	NOUN
dpc-4148	99	24	(	(	PUNCT
dpc-4148	99	25	33.4	33.4	NUM
dpc-4148	99	26	%	%	NOUN
dpc-4148	99	27	)	)	PUNCT
dpc-4148	99	28	had	have	AUX
dpc-4148	99	29	progressed	progress	VERB
dpc-4148	99	30	.	.	PUNCT
dpc-4148	100	1	eleven	eleven	NUM
dpc-4148	100	2	patients	patient	NOUN
dpc-4148	100	3	(	(	PUNCT
dpc-4148	100	4	73.3	73.3	NUM
dpc-4148	100	5	%	%	NOUN
dpc-4148	100	6	)	)	PUNCT
dpc-4148	100	7	stated	state	VERB
dpc-4148	100	8	that	that	SCONJ
dpc-4148	100	9	emotional	emotional	ADJ
dpc-4148	100	10	stress	stress	NOUN
dpc-4148	100	11	could	could	AUX
dpc-4148	100	12	be	be	AUX
dpc-4148	100	13	the	the	DET
dpc-4148	100	14	cause	cause	NOUN
dpc-4148	100	15	of	of	ADP
dpc-4148	100	16	the	the	DET
dpc-4148	100	17	disease	disease	NOUN
dpc-4148	100	18	.	.	PUNCT
dpc-4148	101	1	allergic	allergic	ADJ
dpc-4148	101	2	manifestations	manifestation	NOUN
dpc-4148	101	3	(	(	PUNCT
dpc-4148	101	4	allergic	allergic	ADJ
dpc-4148	101	5	rhinitis	rhinitis	NOUN
dpc-4148	101	6	,	,	PUNCT
dpc-4148	101	7	grass	grass	NOUN
dpc-4148	101	8	allergy	allergy	NOUN
dpc-4148	101	9	,	,	PUNCT
dpc-4148	101	10	pollen	pollen	NOUN
dpc-4148	101	11	allergy	allergy	NOUN
dpc-4148	101	12	,	,	PUNCT
dpc-4148	101	13	etc	etc	X
dpc-4148	101	14	.	.	X
dpc-4148	101	15	)	)	PUNCT
dpc-4148	101	16	were	be	AUX
dpc-4148	101	17	detected	detect	VERB
dpc-4148	101	18	in	in	ADP
dpc-4148	101	19	six	six	NUM
dpc-4148	101	20	of	of	ADP
dpc-4148	101	21	the	the	DET
dpc-4148	101	22	patients	patient	NOUN
dpc-4148	101	23	.	.	PUNCT
dpc-4148	102	1	only	only	ADV
dpc-4148	102	2	two	two	NUM
dpc-4148	102	3	(	(	PUNCT
dpc-4148	102	4	13.3	13.3	NUM
dpc-4148	102	5	%	%	NOUN
dpc-4148	102	6	)	)	PUNCT
dpc-4148	102	7	4	4	NUM
dpc-4148	102	8	original	original	ADJ
dpc-4148	102	9	article	article	NOUN
dpc-4148	102	10	|	|	ADV
dpc-4148	102	11	dermatol	dermatol	ADJ
dpc-4148	102	12	pract	pract	NOUN
dpc-4148	102	13	concept	concept	NOUN
dpc-4148	102	14	.	.	PUNCT
dpc-4148	103	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	103	2	obtained	obtain	VERB
dpc-4148	103	3	in	in	ADP
dpc-4148	103	4	patients	patient	NOUN
dpc-4148	103	5	compared	compare	VERB
dpc-4148	103	6	to	to	ADP
dpc-4148	103	7	healthy	healthy	ADJ
dpc-4148	103	8	individuals	individual	NOUN
dpc-4148	103	9	(	(	PUNCT
dpc-4148	103	10	table	table	NOUN
dpc-4148	103	11	4	4	NUM
dpc-4148	103	12	)	)	PUNCT
dpc-4148	103	13	.	.	PUNCT
dpc-4148	104	1	il-6	il-6	PRON
dpc-4148	104	2	and	and	CCONJ
dpc-4148	104	3	il-17a	il-17a	PROPN
dpc-4148	104	4	levels	level	NOUN
dpc-4148	104	5	,	,	PUNCT
dpc-4148	104	6	which	which	PRON
dpc-4148	104	7	are	be	AUX
dpc-4148	104	8	the	the	DET
dpc-4148	104	9	proinflammatory	proinflammatory	ADJ
dpc-4148	104	10	cytokines	cytokine	NOUN
dpc-4148	104	11	,	,	PUNCT
dpc-4148	104	12	were	be	AUX
dpc-4148	104	13	detected	detect	VERB
dpc-4148	104	14	as	as	ADP
dpc-4148	104	15	200.74	200.74	NUM
dpc-4148	104	16	ng	ng	PROPN
dpc-4148	104	17	/	/	SYM
dpc-4148	104	18	l	l	PROPN
dpc-4148	104	19	±	±	NUM
dpc-4148	104	20	6.96	6.96	NUM
dpc-4148	104	21	and	and	CCONJ
dpc-4148	104	22	277.71	277.71	NUM
dpc-4148	104	23	±	±	NUM
dpc-4148	104	24	15.9	15.9	NUM
dpc-4148	104	25	ng	ng	PROPN
dpc-4148	104	26	/	/	SYM
dpc-4148	104	27	l	l	PROPN
dpc-4148	104	28	,	,	PUNCT
dpc-4148	104	29	respectively	respectively	ADV
dpc-4148	104	30	,	,	PUNCT
dpc-4148	104	31	in	in	ADP
dpc-4148	104	32	the	the	DET
dpc-4148	104	33	group	group	NOUN
dpc-4148	104	34	with	with	ADP
dpc-4148	104	35	morphea	morphea	PROPN
dpc-4148	104	36	,	,	PUNCT
dpc-4148	104	37	an	an	DET
dpc-4148	104	38	approximately	approximately	ADV
dpc-4148	104	39	15	15	NUM
dpc-4148	104	40	%	%	NOUN
dpc-4148	104	41	and	and	CCONJ
dpc-4148	104	42	33	33	NUM
dpc-4148	104	43	%	%	NOUN
dpc-4148	104	44	increase	increase	NOUN
dpc-4148	104	45	,	,	PUNCT
dpc-4148	104	46	respectively	respectively	ADV
dpc-4148	104	47	,	,	PUNCT
dpc-4148	104	48	compared	compare	VERB
dpc-4148	104	49	to	to	ADP
dpc-4148	104	50	the	the	DET
dpc-4148	104	51	173.54	173.54	NUM
dpc-4148	104	52	±	±	NUM
dpc-4148	104	53	7.94	7.94	NUM
dpc-4148	104	54	ng	ng	PROPN
dpc-4148	104	55	/	/	SYM
dpc-4148	104	56	l	l	PROPN
dpc-4148	104	57	and	and	CCONJ
dpc-4148	104	58	209.11	209.11	NUM
dpc-4148	104	59	±	±	NUM
dpc-4148	104	60	2.25	2.25	NUM
dpc-4148	104	61	,	,	PUNCT
dpc-4148	104	62	respectively	respectively	ADV
dpc-4148	104	63	,	,	PUNCT
dpc-4148	104	64	in	in	ADP
dpc-4148	104	65	healthy	healthy	ADJ
dpc-4148	104	66	individuals	individual	NOUN
dpc-4148	104	67	.	.	PUNCT
dpc-4148	105	1	this	this	DET
dpc-4148	105	2	increase	increase	NOUN
dpc-4148	105	3	in	in	ADP
dpc-4148	105	4	il-17a	il-17a	PROPN
dpc-4148	105	5	levels	level	NOUN
dpc-4148	105	6	was	be	AUX
dpc-4148	105	7	significantly	significantly	ADV
dpc-4148	105	8	found	find	VERB
dpc-4148	105	9	as	as	ADP
dpc-4148	105	10	the	the	DET
dpc-4148	105	11	ratio	ratio	NOUN
dpc-4148	105	12	of	of	ADP
dpc-4148	105	13	33	33	NUM
dpc-4148	105	14	%	%	NOUN
dpc-4148	105	15	(	(	PUNCT
dpc-4148	105	16	fig	fig	NOUN
dpc-4148	105	17	1	1	NUM
dpc-4148	105	18	)	)	PUNCT
dpc-4148	105	19	,	,	PUNCT
dpc-4148	105	20	but	but	CCONJ
dpc-4148	105	21	increased	increase	VERB
dpc-4148	105	22	il-6	il-6	NOUN
dpc-4148	105	23	levels	level	NOUN
dpc-4148	105	24	was	be	AUX
dpc-4148	105	25	not	not	PART
dpc-4148	105	26	statistically	statistically	ADV
dpc-4148	105	27	significant	significant	ADJ
dpc-4148	105	28	(	(	PUNCT
dpc-4148	105	29	fig	fig	NOUN
dpc-4148	105	30	2	2	NUM
dpc-4148	105	31	)	)	PUNCT
dpc-4148	105	32	.	.	PUNCT
dpc-4148	106	1	although	although	SCONJ
dpc-4148	106	2	not	not	PART
dpc-4148	106	3	statistically	statistically	ADV
dpc-4148	106	4	significant	significant	ADJ
dpc-4148	106	5	,	,	PUNCT
dpc-4148	106	6	this	this	DET
dpc-4148	106	7	increase	increase	NOUN
dpc-4148	106	8	in	in	ADP
dpc-4148	106	9	il-6	il-6	NUM
dpc-4148	106	10	is	be	AUX
dpc-4148	106	11	very	very	ADV
dpc-4148	106	12	important	important	ADJ
dpc-4148	106	13	for	for	ADP
dpc-4148	106	14	the	the	DET
dpc-4148	106	15	morphea	morphea	PROPN
dpc-4148	106	16	group	group	NOUN
dpc-4148	106	17	since	since	SCONJ
dpc-4148	106	18	it	it	PRON
dpc-4148	106	19	has	have	VERB
dpc-4148	106	20	a	a	DET
dpc-4148	106	21	vital	vital	ADJ
dpc-4148	106	22	role	role	NOUN
dpc-4148	106	23	in	in	ADP
dpc-4148	106	24	the	the	DET
dpc-4148	106	25	pathogenesis	pathogenesis	NOUN
dpc-4148	106	26	of	of	ADP
dpc-4148	106	27	morphea	morphea	PROPN
dpc-4148	106	28	.	.	PUNCT
dpc-4148	107	1	in	in	ADP
dpc-4148	107	2	addition	addition	NOUN
dpc-4148	107	3	to	to	ADP
dpc-4148	107	4	the	the	DET
dpc-4148	107	5	pro	pro	ADJ
dpc-4148	107	6	-	-	ADJ
dpc-4148	107	7	inflammatory	inflammatory	ADJ
dpc-4148	107	8	cytokines	cytokine	NOUN
dpc-4148	107	9	,	,	PUNCT
dpc-4148	107	10	fgf	fgf	PROPN
dpc-4148	107	11	and	and	CCONJ
dpc-4148	107	12	vegf	vegf	PROPN
dpc-4148	107	13	levels	level	NOUN
dpc-4148	107	14	are	be	AUX
dpc-4148	107	15	known	know	VERB
dpc-4148	107	16	to	to	PART
dpc-4148	107	17	play	play	VERB
dpc-4148	107	18	a	a	DET
dpc-4148	107	19	crucial	crucial	ADJ
dpc-4148	107	20	role	role	NOUN
dpc-4148	107	21	in	in	ADP
dpc-4148	107	22	dermal	dermal	ADJ
dpc-4148	107	23	fibrosis	fibrosis	NOUN
dpc-4148	107	24	and	and	CCONJ
dpc-4148	107	25	are	be	AUX
dpc-4148	107	26	implicated	implicate	VERB
dpc-4148	107	27	in	in	ADP
dpc-4148	107	28	the	the	DET
dpc-4148	107	29	pathogenesis	pathogenesis	NOUN
dpc-4148	107	30	of	of	ADP
dpc-4148	107	31	morphea	morphea	PROPN
dpc-4148	107	32	.	.	PUNCT
dpc-4148	108	1	based	base	VERB
dpc-4148	108	2	on	on	ADP
dpc-4148	108	3	our	our	PRON
dpc-4148	108	4	results	result	NOUN
dpc-4148	108	5	,	,	PUNCT
dpc-4148	108	6	fgf	fgf	PROPN
dpc-4148	108	7	and	and	CCONJ
dpc-4148	108	8	vegf	vegf	PROPN
dpc-4148	108	9	levels	level	NOUN
dpc-4148	108	10	were	be	AUX
dpc-4148	108	11	1096.16	1096.16	NUM
dpc-4148	108	12	±	±	NUM
dpc-4148	108	13	25.73	25.73	NUM
dpc-4148	108	14	and	and	CCONJ
dpc-4148	108	15	1202.41	1202.41	NUM
dpc-4148	108	16	±	±	NUM
dpc-4148	108	17	37.15	37.15	NUM
dpc-4148	108	18	ng	ng	PROPN
dpc-4148	108	19	/	/	SYM
dpc-4148	108	20	l	l	PROPN
dpc-4148	108	21	,	,	PUNCT
dpc-4148	108	22	respectively	respectively	ADV
dpc-4148	108	23	,	,	PUNCT
dpc-4148	108	24	in	in	ADP
dpc-4148	108	25	the	the	DET
dpc-4148	108	26	healthy	healthy	ADJ
dpc-4148	108	27	group	group	NOUN
dpc-4148	108	28	,	,	PUNCT
dpc-4148	108	29	and	and	CCONJ
dpc-4148	108	30	1503.18	1503.18	NUM
dpc-4148	108	31	±	±	NUM
dpc-4148	108	32	83.4	83.4	NUM
dpc-4148	108	33	(	(	PUNCT
dpc-4148	108	34	fig	fig	NOUN
dpc-4148	108	35	.	.	PUNCT
dpc-4148	109	1	3	3	NUM
dpc-4148	109	2	)	)	PUNCT
dpc-4148	109	3	and	and	CCONJ
dpc-4148	109	4	1568.44	1568.44	NUM
dpc-4148	109	5	±	±	NUM
dpc-4148	109	6	82.16	82.16	NUM
dpc-4148	109	7	ng	ng	PROPN
dpc-4148	109	8	/	/	SYM
dpc-4148	109	9	l	l	PROPN
dpc-4148	109	10	,	,	PUNCT
dpc-4148	109	11	respectively	respectively	ADV
dpc-4148	109	12	,	,	PUNCT
dpc-4148	109	13	in	in	ADP
dpc-4148	109	14	the	the	DET
dpc-4148	109	15	morphea	morphea	PROPN
dpc-4148	109	16	group	group	NOUN
dpc-4148	109	17	(	(	PUNCT
dpc-4148	109	18	fig	fig	NOUN
dpc-4148	109	19	.	.	PUNCT
dpc-4148	109	20	4	4	NUM
dpc-4148	109	21	)	)	PUNCT
dpc-4148	109	22	.	.	PUNCT
dpc-4148	110	1	both	both	DET
dpc-4148	110	2	growth	growth	NOUN
dpc-4148	110	3	factor	factor	NOUN
dpc-4148	110	4	levels	level	NOUN
dpc-4148	110	5	were	be	AUX
dpc-4148	110	6	significantly	significantly	ADV
dpc-4148	110	7	increased	increase	VERB
dpc-4148	110	8	in	in	ADP
dpc-4148	110	9	serum	serum	NOUN
dpc-4148	110	10	samples	sample	NOUN
dpc-4148	110	11	of	of	ADP
dpc-4148	110	12	morphea	morphea	ADJ
dpc-4148	110	13	patients	patient	NOUN
dpc-4148	110	14	compared	compare	VERB
dpc-4148	110	15	with	with	ADP
dpc-4148	110	16	the	the	DET
dpc-4148	110	17	healthy	healthy	ADJ
dpc-4148	110	18	group	group	NOUN
dpc-4148	110	19	,	,	PUNCT
dpc-4148	110	20	as	as	ADP
dpc-4148	110	21	the	the	DET
dpc-4148	110	22	ratio	ratio	NOUN
dpc-4148	110	23	of	of	ADP
dpc-4148	110	24	37	37	NUM
dpc-4148	110	25	%	%	NOUN
dpc-4148	110	26	in	in	ADP
dpc-4148	110	27	fgf	fgf	PROPN
dpc-4148	110	28	and	and	CCONJ
dpc-4148	110	29	30	30	NUM
dpc-4148	110	30	%	%	NOUN
dpc-4148	110	31	in	in	ADP
dpc-4148	110	32	vegf	vegf	PROPN
dpc-4148	110	33	(	(	PUNCT
dpc-4148	110	34	p<0.05	p<0.05	PROPN
dpc-4148	110	35	)	)	PUNCT
dpc-4148	110	36	.	.	PUNCT
dpc-4148	111	1	of	of	ADP
dpc-4148	111	2	the	the	DET
dpc-4148	111	3	patients	patient	NOUN
dpc-4148	111	4	were	be	AUX
dpc-4148	111	5	active	active	ADJ
dpc-4148	111	6	smokers	smoker	NOUN
dpc-4148	111	7	.	.	PUNCT
dpc-4148	112	1	in	in	ADP
dpc-4148	112	2	the	the	DET
dpc-4148	112	3	family	family	NOUN
dpc-4148	112	4	histories	history	NOUN
dpc-4148	112	5	of	of	ADP
dpc-4148	112	6	the	the	DET
dpc-4148	112	7	patients	patient	NOUN
dpc-4148	112	8	,	,	PUNCT
dpc-4148	112	9	it	it	PRON
dpc-4148	112	10	was	be	AUX
dpc-4148	112	11	determined	determine	VERB
dpc-4148	112	12	that	that	SCONJ
dpc-4148	112	13	the	the	DET
dpc-4148	112	14	brother	brother	NOUN
dpc-4148	112	15	of	of	ADP
dpc-4148	112	16	one	one	NUM
dpc-4148	112	17	patient	patient	NOUN
dpc-4148	112	18	also	also	ADV
dpc-4148	112	19	had	have	VERB
dpc-4148	112	20	morphea	morphea	NOUN
dpc-4148	112	21	,	,	PUNCT
dpc-4148	112	22	and	and	CCONJ
dpc-4148	112	23	the	the	DET
dpc-4148	112	24	relatives	relative	NOUN
dpc-4148	112	25	of	of	ADP
dpc-4148	112	26	five	five	NUM
dpc-4148	112	27	patients	patient	NOUN
dpc-4148	112	28	had	have	VERB
dpc-4148	112	29	various	various	ADJ
dpc-4148	112	30	autoimmune	autoimmune	ADJ
dpc-4148	112	31	diseases	disease	NOUN
dpc-4148	112	32	(	(	PUNCT
dpc-4148	112	33	rheumatic	rheumatic	ADJ
dpc-4148	112	34	diseases	disease	NOUN
dpc-4148	112	35	,	,	PUNCT
dpc-4148	112	36	thyroid	thyroid	NOUN
dpc-4148	112	37	diseases	disease	NOUN
dpc-4148	112	38	,	,	PUNCT
dpc-4148	112	39	etc	etc	X
dpc-4148	112	40	.	.	X
dpc-4148	112	41	)	)	PUNCT
dpc-4148	112	42	.	.	PUNCT
dpc-4148	113	1	demographic	demographic	ADJ
dpc-4148	113	2	data	datum	NOUN
dpc-4148	113	3	of	of	ADP
dpc-4148	113	4	patients	patient	NOUN
dpc-4148	113	5	and	and	CCONJ
dpc-4148	113	6	healthy	healthy	ADJ
dpc-4148	113	7	controls	control	NOUN
dpc-4148	113	8	are	be	AUX
dpc-4148	113	9	shown	show	VERB
dpc-4148	113	10	in	in	ADP
dpc-4148	113	11	table	table	NOUN
dpc-4148	113	12	2	2	NUM
dpc-4148	113	13	.	.	PUNCT
dpc-4148	113	14	as	as	SCONJ
dpc-4148	113	15	a	a	DET
dpc-4148	113	16	result	result	NOUN
dpc-4148	113	17	of	of	ADP
dpc-4148	113	18	our	our	PRON
dpc-4148	113	19	study	study	NOUN
dpc-4148	113	20	,	,	PUNCT
dpc-4148	113	21	expressions	expression	NOUN
dpc-4148	113	22	of	of	ADP
dpc-4148	113	23	tlr	tlr	PROPN
dpc-4148	113	24	genes	gene	NOUN
dpc-4148	113	25	were	be	AUX
dpc-4148	113	26	investigated	investigate	VERB
dpc-4148	113	27	in	in	ADP
dpc-4148	113	28	perilesional	perilesional	ADJ
dpc-4148	113	29	and	and	CCONJ
dpc-4148	113	30	lesional	lesional	ADJ
dpc-4148	113	31	morphea	morphea	NOUN
dpc-4148	113	32	tissues	tissue	NOUN
dpc-4148	113	33	and	and	CCONJ
dpc-4148	113	34	compared	compare	VERB
dpc-4148	113	35	to	to	ADP
dpc-4148	113	36	the	the	DET
dpc-4148	113	37	controls	control	NOUN
dpc-4148	113	38	.	.	PUNCT
dpc-4148	114	1	expressions	expression	NOUN
dpc-4148	114	2	of	of	ADP
dpc-4148	114	3	tlr1	tlr1	PROPN
dpc-4148	114	4	,	,	PUNCT
dpc-4148	114	5	2	2	NUM
dpc-4148	114	6	,	,	PUNCT
dpc-4148	114	7	3	3	NUM
dpc-4148	114	8	,	,	PUNCT
dpc-4148	114	9	6	6	NUM
dpc-4148	114	10	,	,	PUNCT
dpc-4148	114	11	8	8	NUM
dpc-4148	114	12	,	,	PUNCT
dpc-4148	114	13	9	9	NUM
dpc-4148	114	14	,	,	PUNCT
dpc-4148	114	15	and	and	CCONJ
dpc-4148	114	16	10	10	NUM
dpc-4148	114	17	genes	gene	NOUN
dpc-4148	114	18	were	be	AUX
dpc-4148	114	19	found	find	VERB
dpc-4148	114	20	to	to	PART
dpc-4148	114	21	be	be	AUX
dpc-4148	114	22	upregulated	upregulate	VERB
dpc-4148	114	23	in	in	ADP
dpc-4148	114	24	the	the	DET
dpc-4148	114	25	perilesional	perilesional	ADJ
dpc-4148	114	26	group	group	NOUN
dpc-4148	114	27	,	,	PUNCT
dpc-4148	114	28	but	but	CCONJ
dpc-4148	114	29	statistical	statistical	ADJ
dpc-4148	114	30	significance	significance	NOUN
dpc-4148	114	31	could	could	AUX
dpc-4148	114	32	not	not	PART
dpc-4148	114	33	be	be	AUX
dpc-4148	114	34	determined	determine	VERB
dpc-4148	114	35	(	(	PUNCT
dpc-4148	114	36	p>0.05	p>0.05	NOUN
dpc-4148	114	37	)	)	PUNCT
dpc-4148	114	38	(	(	PUNCT
dpc-4148	114	39	table	table	NOUN
dpc-4148	114	40	3	3	NUM
dpc-4148	114	41	)	)	PUNCT
dpc-4148	114	42	.	.	PUNCT
dpc-4148	115	1	tlr	tlr	PROPN
dpc-4148	115	2	4	4	NUM
dpc-4148	115	3	,	,	PUNCT
dpc-4148	115	4	5	5	NUM
dpc-4148	115	5	,	,	PUNCT
dpc-4148	115	6	and	and	CCONJ
dpc-4148	115	7	7	7	NUM
dpc-4148	115	8	gene	gene	NOUN
dpc-4148	115	9	expressions	expression	NOUN
dpc-4148	115	10	were	be	AUX
dpc-4148	115	11	determined	determine	VERB
dpc-4148	115	12	to	to	PART
dpc-4148	115	13	be	be	AUX
dpc-4148	115	14	down	down	ADV
dpc-4148	115	15	-	-	PUNCT
dpc-4148	115	16	regulated	regulate	VERB
dpc-4148	115	17	,	,	PUNCT
dpc-4148	115	18	but	but	CCONJ
dpc-4148	115	19	statistical	statistical	ADJ
dpc-4148	115	20	significance	significance	NOUN
dpc-4148	115	21	could	could	AUX
dpc-4148	115	22	not	not	PART
dpc-4148	115	23	be	be	AUX
dpc-4148	115	24	determined	determine	VERB
dpc-4148	115	25	.	.	PUNCT
dpc-4148	116	1	in	in	ADP
dpc-4148	116	2	the	the	DET
dpc-4148	116	3	lesional	lesional	ADJ
dpc-4148	116	4	group	group	NOUN
dpc-4148	116	5	,	,	PUNCT
dpc-4148	116	6	a	a	DET
dpc-4148	116	7	34.3	34.3	NUM
dpc-4148	116	8	-	-	ADJ
dpc-4148	116	9	fold	fold	ADJ
dpc-4148	116	10	increase	increase	NOUN
dpc-4148	116	11	in	in	ADP
dpc-4148	116	12	tlr1	tlr1	PROPN
dpc-4148	116	13	gene	gene	NOUN
dpc-4148	116	14	expression	expression	NOUN
dpc-4148	116	15	was	be	AUX
dpc-4148	116	16	found	find	VERB
dpc-4148	116	17	to	to	PART
dpc-4148	116	18	be	be	AUX
dpc-4148	116	19	statistically	statistically	ADV
dpc-4148	116	20	significant	significant	ADJ
dpc-4148	116	21	.	.	PUNCT
dpc-4148	117	1	the	the	DET
dpc-4148	117	2	increase	increase	NOUN
dpc-4148	117	3	in	in	ADP
dpc-4148	117	4	tlr	tlr	PROPN
dpc-4148	117	5	2	2	NUM
dpc-4148	117	6	,	,	PUNCT
dpc-4148	117	7	3	3	NUM
dpc-4148	117	8	,	,	PUNCT
dpc-4148	117	9	6	6	NUM
dpc-4148	117	10	,	,	PUNCT
dpc-4148	117	11	8	8	NUM
dpc-4148	117	12	,	,	PUNCT
dpc-4148	117	13	9	9	NUM
dpc-4148	117	14	,	,	PUNCT
dpc-4148	117	15	and	and	CCONJ
dpc-4148	117	16	10	10	NUM
dpc-4148	117	17	genes	gene	NOUN
dpc-4148	117	18	and	and	CCONJ
dpc-4148	117	19	the	the	DET
dpc-4148	117	20	decrease	decrease	NOUN
dpc-4148	117	21	in	in	ADP
dpc-4148	117	22	tlr4	tlr4	NOUN
dpc-4148	117	23	,	,	PUNCT
dpc-4148	117	24	5	5	NUM
dpc-4148	117	25	,	,	PUNCT
dpc-4148	117	26	and	and	CCONJ
dpc-4148	117	27	7	7	NUM
dpc-4148	117	28	gene	gene	NOUN
dpc-4148	117	29	expressions	expression	NOUN
dpc-4148	117	30	were	be	AUX
dpc-4148	117	31	not	not	PART
dpc-4148	117	32	statistically	statistically	ADV
dpc-4148	117	33	significant	significant	ADJ
dpc-4148	117	34	.	.	PUNCT
dpc-4148	118	1	to	to	PART
dpc-4148	118	2	evaluate	evaluate	VERB
dpc-4148	118	3	the	the	DET
dpc-4148	118	4	changes	change	NOUN
dpc-4148	118	5	of	of	ADP
dpc-4148	118	6	key	key	ADJ
dpc-4148	118	7	mediators	mediator	NOUN
dpc-4148	118	8	in	in	ADP
dpc-4148	118	9	morphea	morphea	ADJ
dpc-4148	118	10	pathogenesis	pathogenesis	NOUN
dpc-4148	118	11	,	,	PUNCT
dpc-4148	118	12	il-6	il-6	NUM
dpc-4148	118	13	,	,	PUNCT
dpc-4148	118	14	il-17a	il-17a	PROPN
dpc-4148	118	15	,	,	PUNCT
dpc-4148	118	16	tgf	tgf	PROPN
dpc-4148	118	17	-	-	PUNCT
dpc-4148	118	18	β1	β1	PROPN
dpc-4148	118	19	,	,	PUNCT
dpc-4148	118	20	fgf	fgf	PROPN
dpc-4148	118	21	,	,	PUNCT
dpc-4148	118	22	and	and	CCONJ
dpc-4148	118	23	vegf	vegf	PROPN
dpc-4148	118	24	levels	level	NOUN
dpc-4148	118	25	were	be	AUX
dpc-4148	118	26	measured	measure	VERB
dpc-4148	118	27	in	in	ADP
dpc-4148	118	28	serum	serum	NOUN
dpc-4148	118	29	samples	sample	NOUN
dpc-4148	118	30	of	of	ADP
dpc-4148	118	31	health	health	NOUN
dpc-4148	118	32	individuals	individual	NOUN
dpc-4148	118	33	and	and	CCONJ
dpc-4148	118	34	morphea	morphea	NOUN
dpc-4148	118	35	patients	patient	NOUN
dpc-4148	118	36	.	.	PUNCT
dpc-4148	119	1	based	base	VERB
dpc-4148	119	2	on	on	ADP
dpc-4148	119	3	our	our	PRON
dpc-4148	119	4	results	result	NOUN
dpc-4148	119	5	,	,	PUNCT
dpc-4148	119	6	an	an	DET
dpc-4148	119	7	increase	increase	NOUN
dpc-4148	119	8	in	in	ADP
dpc-4148	119	9	both	both	DET
dpc-4148	119	10	levels	level	NOUN
dpc-4148	119	11	of	of	ADP
dpc-4148	119	12	cytokine	cytokine	ADJ
dpc-4148	119	13	and	and	CCONJ
dpc-4148	119	14	growth	growth	NOUN
dpc-4148	119	15	factors	factor	NOUN
dpc-4148	119	16	were	be	AUX
dpc-4148	119	17	significantly	significantly	ADV
dpc-4148	119	18	table	table	NOUN
dpc-4148	119	19	1	1	NUM
dpc-4148	119	20	.	.	PUNCT
dpc-4148	120	1	reverse	reverse	VERB
dpc-4148	120	2	and	and	CCONJ
dpc-4148	120	3	forward	forward	ADJ
dpc-4148	120	4	sequences	sequence	NOUN
dpc-4148	120	5	of	of	ADP
dpc-4148	120	6	genes	gene	NOUN
dpc-4148	120	7	used	use	VERB
dpc-4148	120	8	in	in	ADP
dpc-4148	120	9	the	the	DET
dpc-4148	120	10	study	study	NOUN
dpc-4148	120	11	.	.	PUNCT
dpc-4148	121	1	#	#	NOUN
dpc-4148	121	2	name	name	NOUN
dpc-4148	121	3	sequence	sequence	NOUN
dpc-4148	121	4	1	1	NUM
dpc-4148	121	5	tlr1_f	tlr1_f	NOUN
dpc-4148	121	6	cagcgatgtgttcggttttccg	cagcgatgtgttcggttttccg	PROPN
dpc-4148	121	7	2	2	NUM
dpc-4148	121	8	tlr1_r	tlr1_r	NOUN
dpc-4148	121	9	gatgggcaaagcatgtggacca	gatgggcaaagcatgtggacca	VERB
dpc-4148	121	10	3	3	NUM
dpc-4148	121	11	tlr2_f	tlr2_f	NOUN
dpc-4148	121	12	ttatccagcacacgaatacacag	ttatccagcacacgaatacacag	PROPN
dpc-4148	121	13	4	4	NUM
dpc-4148	121	14	tlr2_r	tlr2_r	NOUN
dpc-4148	121	15	aggcatctggtagagtcatcaa	aggcatctggtagagtcatcaa	VERB
dpc-4148	121	16	5	5	NUM
dpc-4148	121	17	tlr3_f	tlr3_f	PROPN
dpc-4148	122	1	ggctagcagtcatccaacagaa	ggctagcagtcatccaacagaa	NOUN
dpc-4148	122	2	6	6	NUM
dpc-4148	122	3	tlr3_r	tlr3_r	NOUN
dpc-4148	122	4	gcagtcagcaacttcatggc	gcagtcagcaacttcatggc	NOUN
dpc-4148	122	5	7	7	NUM
dpc-4148	122	6	tlr4_f	tlr4_f	AUX
dpc-4148	122	7	ccctgaggcatttaggcagcta	ccctgaggcatttaggcagcta	VERB
dpc-4148	122	8	8	8	NUM
dpc-4148	122	9	tlr4_r	tlr4_r	ADP
dpc-4148	122	10	aggtagagaggtggcttaggct	aggtagagaggtggcttaggct	PROPN
dpc-4148	122	11	9	9	NUM
dpc-4148	122	12	tlr5_f	tlr5_f	PROPN
dpc-4148	122	13	ccttacagcgaacctcatccac	ccttacagcgaacctcatccac	PROPN
dpc-4148	122	14	10	10	NUM
dpc-4148	122	15	tlr5_r	tlr5_r	NOUN
dpc-4148	122	16	tccactacaggaggagaagcga	tccactacaggaggagaagcga	ADJ
dpc-4148	122	17	11	11	NUM
dpc-4148	122	18	tlr6_f	tlr6_f	PROPN
dpc-4148	122	19	ttctccgacggaaatgaatttgc	ttctccgacggaaatgaatttgc	ADJ
dpc-4148	122	20	12	12	NUM
dpc-4148	122	21	tlr6_r	tlr6_r	PROPN
dpc-4148	122	22	cagcggtaggtcttttggaac	cagcggtaggtcttttggaac	NOUN
dpc-4148	122	23	13	13	NUM
dpc-4148	122	24	tlr7_f	tlr7_f	PRON
dpc-4148	122	25	ctttggacctcagccacaacca	ctttggacctcagccacaacca	VERB
dpc-4148	122	26	14	14	NUM
dpc-4148	122	27	tlr7_r	tlr7_r	NOUN
dpc-4148	122	28	cgcaactggaaggcatcttgtag	cgcaactggaaggcatcttgtag	ADJ
dpc-4148	122	29	15	15	NUM
dpc-4148	122	30	tlr8_f	tlr8_f	NOUN
dpc-4148	122	31	actccagcagtttcctcgtctc	actccagcagtttcctcgtctc	NOUN
dpc-4148	122	32	16	16	NUM
dpc-4148	122	33	tlr8_r	tlr8_r	NOUN
dpc-4148	122	34	aaagccagagggtaggtgggaa	aaagccagagggtaggtgggaa	NOUN
dpc-4148	122	35	17	17	NUM
dpc-4148	122	36	tlr9_f	tlr9_f	NOUN
dpc-4148	122	37	tgagccacaactgcatctcgca	tgagccacaactgcatctcgca	NOUN
dpc-4148	122	38	18	18	NUM
dpc-4148	122	39	tlr9_r	tlr9_r	NOUN
dpc-4148	122	40	cagtcgtggtagctccgtgaat	cagtcgtggtagctccgtgaat	VERB
dpc-4148	122	41	19	19	NUM
dpc-4148	122	42	tlr10_f	tlr10_f	PROPN
dpc-4148	122	43	ggttaaaagacgttcatctccacg	ggttaaaagacgttcatctccacg	PROPN
dpc-4148	122	44	20	20	NUM
dpc-4148	122	45	tlr10_r	tlr10_r	PROPN
dpc-4148	122	46	cctagcatcctgagataccagg	cctagcatcctgagataccagg	NOUN
dpc-4148	122	47	21	21	NUM
dpc-4148	122	48	b	b	X
dpc-4148	122	49	-	-	PUNCT
dpc-4148	122	50	aktin_f	aktin_f	NOUN
dpc-4148	122	51	tcctcctgagcgcaagtactc	tcctcctgagcgcaagtactc	NOUN
dpc-4148	122	52	22	22	NUM
dpc-4148	122	53	b	b	NUM
dpc-4148	122	54	-	-	PUNCT
dpc-4148	122	55	aktin_r	aktin_r	NOUN
dpc-4148	122	56	ctgcttgctgatccacatctg	ctgcttgctgatccacatctg	VERB
dpc-4148	122	57	original	original	ADJ
dpc-4148	122	58	article	article	NOUN
dpc-4148	122	59	|	|	ADV
dpc-4148	122	60	dermatol	dermatol	ADJ
dpc-4148	122	61	pract	pract	NOUN
dpc-4148	122	62	concept	concept	NOUN
dpc-4148	122	63	.	.	PUNCT
dpc-4148	123	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	123	2	5	5	NUM
dpc-4148	123	3	table	table	NOUN
dpc-4148	123	4	2	2	NUM
dpc-4148	123	5	.	.	PUNCT
dpc-4148	123	6	demographic	demographic	ADJ
dpc-4148	123	7	data	datum	NOUN
dpc-4148	123	8	of	of	ADP
dpc-4148	123	9	the	the	DET
dpc-4148	123	10	participants	participant	NOUN
dpc-4148	123	11	.	.	PUNCT
dpc-4148	124	1	patients	patient	NOUN
dpc-4148	124	2	(	(	PUNCT
dpc-4148	124	3	n=15	n=15	NUM
dpc-4148	124	4	)	)	PUNCT
dpc-4148	124	5	healthy	healthy	ADJ
dpc-4148	124	6	controls	control	NOUN
dpc-4148	124	7	(	(	PUNCT
dpc-4148	124	8	n=11	n=11	NOUN
dpc-4148	124	9	)	)	PUNCT
dpc-4148	124	10	p	p	NOUN
dpc-4148	124	11	-	-	PUNCT
dpc-4148	124	12	value	value	NOUN
dpc-4148	124	13	*	*	X
dpc-4148	124	14	age	age	NOUN
dpc-4148	124	15	,	,	PUNCT
dpc-4148	124	16	years	year	NOUN
dpc-4148	124	17	44.43	44.43	NUM
dpc-4148	124	18	±	±	NOUN
dpc-4148	124	19	14.29†	14.29†	NUM
dpc-4148	124	20	43.91	43.91	NUM
dpc-4148	124	21	±	±	NOUN
dpc-4148	124	22	15.78†	15.78†	NUM
dpc-4148	124	23	0.623	0.623	NUM
dpc-4148	124	24	female	female	NOUN
dpc-4148	124	25	,	,	PUNCT
dpc-4148	124	26	n	n	CCONJ
dpc-4148	124	27	(	(	PUNCT
dpc-4148	124	28	%	%	INTJ
dpc-4148	124	29	)	)	PUNCT
dpc-4148	124	30	male	male	NOUN
dpc-4148	124	31	,	,	PUNCT
dpc-4148	124	32	n	n	CCONJ
dpc-4148	124	33	(	(	PUNCT
dpc-4148	124	34	%	%	INTJ
dpc-4148	124	35	)	)	PUNCT
dpc-4148	124	36	12	12	NUM
dpc-4148	124	37	(	(	PUNCT
dpc-4148	124	38	%	%	NOUN
dpc-4148	124	39	80	80	NUM
dpc-4148	124	40	)	)	PUNCT
dpc-4148	124	41	9	9	NUM
dpc-4148	124	42	(	(	PUNCT
dpc-4148	124	43	%	%	INTJ
dpc-4148	124	44	81.8	81.8	NUM
dpc-4148	124	45	)	)	PUNCT
dpc-4148	124	46	0.241	0.241	NUM
dpc-4148	124	47	3	3	NUM
dpc-4148	124	48	(	(	PUNCT
dpc-4148	124	49	%	%	NOUN
dpc-4148	124	50	20	20	NUM
dpc-4148	124	51	)	)	PUNCT
dpc-4148	124	52	2	2	NUM
dpc-4148	124	53	(	(	PUNCT
dpc-4148	124	54	%	%	NOUN
dpc-4148	124	55	18.2	18.2	NUM
dpc-4148	124	56	)	)	PUNCT
dpc-4148	124	57	duration	duration	NOUN
dpc-4148	124	58	of	of	ADP
dpc-4148	124	59	disease	disease	NOUN
dpc-4148	124	60	,	,	PUNCT
dpc-4148	124	61	years	year	NOUN
dpc-4148	124	62	4.71	4.71	NUM
dpc-4148	124	63	±	±	NUM
dpc-4148	124	64	7.2†	7.2†	NUM
dpc-4148	124	65	(	(	PUNCT
dpc-4148	124	66	0.5	0.5	NUM
dpc-4148	124	67	-	-	SYM
dpc-4148	124	68	12	12	NUM
dpc-4148	124	69	)	)	PUNCT
dpc-4148	124	70	mlossi	mlossi	NOUN
dpc-4148	124	71	score	score	NOUN
dpc-4148	124	72	losdi	losdi	NOUN
dpc-4148	124	73	score	score	NOUN
dpc-4148	124	74	15.375	15.375	NUM
dpc-4148	124	75	±	±	NUM
dpc-4148	124	76	17.2†	17.2†	NUM
dpc-4148	124	77	16.875	16.875	NUM
dpc-4148	124	78	±	±	NUM
dpc-4148	125	1	27.2†	27.2†	NUM
dpc-4148	125	2	allergic	allergic	ADJ
dpc-4148	125	3	conditions	condition	NOUN
dpc-4148	125	4	(	(	PUNCT
dpc-4148	125	5	allergic	allergic	ADJ
dpc-4148	125	6	rhinitis	rhinitis	NOUN
dpc-4148	125	7	,	,	PUNCT
dpc-4148	125	8	pollen	pollen	NOUN
dpc-4148	125	9	allergy	allergy	NOUN
dpc-4148	125	10	,	,	PUNCT
dpc-4148	125	11	etc	etc	X
dpc-4148	125	12	.	.	X
dpc-4148	125	13	)	)	PUNCT
dpc-4148	125	14	6	6	NUM
dpc-4148	125	15	(	(	PUNCT
dpc-4148	125	16	%	%	NOUN
dpc-4148	125	17	40	40	NUM
dpc-4148	125	18	)	)	PUNCT
dpc-4148	125	19	0	0	NUM
dpc-4148	125	20	(	(	PUNCT
dpc-4148	125	21	0	0	NUM
dpc-4148	125	22	%	%	NOUN
dpc-4148	125	23	)	)	PUNCT
dpc-4148	125	24	smokers	smoker	NOUN
dpc-4148	125	25	,	,	PUNCT
dpc-4148	125	26	n	n	CCONJ
dpc-4148	125	27	(	(	PUNCT
dpc-4148	125	28	%	%	INTJ
dpc-4148	125	29	)	)	PUNCT
dpc-4148	125	30	non	non	NOUN
dpc-4148	125	31	-	-	NOUN
dpc-4148	125	32	smokers	smoker	NOUN
dpc-4148	125	33	,	,	PUNCT
dpc-4148	125	34	n	n	CCONJ
dpc-4148	125	35	(	(	PUNCT
dpc-4148	125	36	%	%	INTJ
dpc-4148	125	37	)	)	PUNCT
dpc-4148	125	38	2	2	NUM
dpc-4148	125	39	(	(	PUNCT
dpc-4148	125	40	%	%	NOUN
dpc-4148	125	41	13.3	13.3	NUM
dpc-4148	125	42	)	)	PUNCT
dpc-4148	125	43	13	13	NUM
dpc-4148	125	44	(	(	PUNCT
dpc-4148	125	45	%	%	NOUN
dpc-4148	125	46	86.7	86.7	NUM
dpc-4148	125	47	)	)	PUNCT
dpc-4148	125	48	1	1	NUM
dpc-4148	125	49	(	(	PUNCT
dpc-4148	125	50	%	%	NOUN
dpc-4148	125	51	9.1	9.1	NUM
dpc-4148	125	52	)	)	PUNCT
dpc-4148	125	53	10	10	NUM
dpc-4148	125	54	(	(	PUNCT
dpc-4148	125	55	%	%	NOUN
dpc-4148	125	56	90.9	90.9	NUM
dpc-4148	125	57	)	)	PUNCT
dpc-4148	125	58	0.153	0.153	NUM
dpc-4148	125	59	status	status	NOUN
dpc-4148	125	60	of	of	ADP
dpc-4148	125	61	the	the	DET
dpc-4148	125	62	disease	disease	NOUN
dpc-4148	125	63	(	(	PUNCT
dpc-4148	125	64	last	last	ADJ
dpc-4148	125	65	6	6	NUM
dpc-4148	125	66	months	month	NOUN
dpc-4148	125	67	)	)	PUNCT
dpc-4148	125	68	stabile	stabile	ADJ
dpc-4148	125	69	progressive	progressive	ADJ
dpc-4148	125	70	10	10	NUM
dpc-4148	125	71	(	(	PUNCT
dpc-4148	125	72	%	%	NOUN
dpc-4148	125	73	66.6	66.6	NUM
dpc-4148	125	74	)	)	PUNCT
dpc-4148	125	75	5	5	NUM
dpc-4148	125	76	(	(	PUNCT
dpc-4148	125	77	%	%	NOUN
dpc-4148	125	78	33.4	33.4	NUM
dpc-4148	125	79	)	)	PUNCT
dpc-4148	125	80	having	have	VERB
dpc-4148	125	81	a	a	DET
dpc-4148	125	82	family	family	NOUN
dpc-4148	125	83	history	history	NOUN
dpc-4148	125	84	of	of	ADP
dpc-4148	125	85	morphea	morphea	PROPN
dpc-4148	125	86	,	,	PUNCT
dpc-4148	125	87	n	n	PROPN
dpc-4148	125	88	(	(	PUNCT
dpc-4148	125	89	%	%	INTJ
dpc-4148	125	90	)	)	PUNCT
dpc-4148	125	91	having	have	VERB
dpc-4148	125	92	a	a	DET
dpc-4148	125	93	family	family	NOUN
dpc-4148	125	94	history	history	NOUN
dpc-4148	125	95	of	of	ADP
dpc-4148	125	96	other	other	ADJ
dpc-4148	125	97	autoimmune	autoimmune	ADJ
dpc-4148	125	98	diseases	disease	NOUN
dpc-4148	125	99	,	,	PUNCT
dpc-4148	125	100	n	n	CCONJ
dpc-4148	125	101	(	(	PUNCT
dpc-4148	125	102	%	%	INTJ
dpc-4148	125	103	)	)	PUNCT
dpc-4148	125	104	1	1	NUM
dpc-4148	125	105	(	(	PUNCT
dpc-4148	125	106	%	%	NOUN
dpc-4148	125	107	6.6	6.6	NUM
dpc-4148	125	108	)	)	SYM
dpc-4148	125	109	5	5	NUM
dpc-4148	125	110	(	(	PUNCT
dpc-4148	125	111	%	%	NOUN
dpc-4148	125	112	33.3	33.3	NUM
dpc-4148	125	113	)	)	PUNCT
dpc-4148	125	114	p	p	X
dpc-4148	125	115	*	*	PUNCT
dpc-4148	125	116	:	:	PUNCT
dpc-4148	125	117	mann	mann	PROPN
dpc-4148	125	118	whitney	whitney	PROPN
dpc-4148	125	119	u	u	PROPN
dpc-4148	125	120	;	;	PUNCT
dpc-4148	125	121	†	†	NOUN
dpc-4148	125	122	:	:	PUNCT
dpc-4148	125	123	standard	standard	ADJ
dpc-4148	125	124	deviation	deviation	NOUN
dpc-4148	125	125	.	.	PUNCT
dpc-4148	126	1	table	table	NOUN
dpc-4148	126	2	3	3	NUM
dpc-4148	126	3	.	.	PUNCT
dpc-4148	126	4	comparison	comparison	NOUN
dpc-4148	126	5	of	of	ADP
dpc-4148	126	6	tlr	tlr	PROPN
dpc-4148	126	7	expressions	expression	NOUN
dpc-4148	126	8	in	in	ADP
dpc-4148	126	9	lesional	lesional	ADJ
dpc-4148	126	10	and	and	CCONJ
dpc-4148	126	11	perilesional	perilesional	ADJ
dpc-4148	126	12	skin	skin	NOUN
dpc-4148	126	13	of	of	ADP
dpc-4148	126	14	the	the	DET
dpc-4148	126	15	patient	patient	ADJ
dpc-4148	126	16	group	group	NOUN
dpc-4148	126	17	with	with	ADP
dpc-4148	126	18	expressions	expression	NOUN
dpc-4148	126	19	in	in	ADP
dpc-4148	126	20	the	the	DET
dpc-4148	126	21	skin	skin	NOUN
dpc-4148	126	22	of	of	ADP
dpc-4148	126	23	healthy	healthy	ADJ
dpc-4148	126	24	controls	control	NOUN
dpc-4148	126	25	.	.	PUNCT
dpc-4148	127	1	genes	gene	NOUN
dpc-4148	127	2	group	group	NOUN
dpc-4148	127	3	1	1	NUM
dpc-4148	127	4	(	(	PUNCT
dpc-4148	127	5	perilesional	perilesional	ADJ
dpc-4148	127	6	)	)	PUNCT
dpc-4148	127	7	group	group	NOUN
dpc-4148	127	8	2	2	NUM
dpc-4148	127	9	(	(	PUNCT
dpc-4148	127	10	lesional	lesional	ADJ
dpc-4148	127	11	)	)	PUNCT
dpc-4148	127	12	fold	fold	ADJ
dpc-4148	127	13	regulation	regulation	NOUN
dpc-4148	127	14	p	p	NOUN
dpc-4148	127	15	-	-	PUNCT
dpc-4148	127	16	value	value	NOUN
dpc-4148	127	17	fold	fold	ADJ
dpc-4148	127	18	regulation	regulation	NOUN
dpc-4148	127	19	p	p	NOUN
dpc-4148	127	20	-	-	PUNCT
dpc-4148	127	21	value	value	NOUN
dpc-4148	127	22	tlr1	tlr1	NOUN
dpc-4148	127	23	39.89	39.89	NUM
dpc-4148	127	24	0.161145	0.161145	NUM
dpc-4148	127	25	34.33	34.33	NUM
dpc-4148	127	26	0.045850	0.045850	NUM
dpc-4148	127	27	*	*	PUNCT
dpc-4148	127	28	tlr2	tlr2	VERB
dpc-4148	127	29	9.56	9.56	NUM
dpc-4148	127	30	0.228178	0.228178	NUM
dpc-4148	127	31	7.97	7.97	NUM
dpc-4148	127	32	0.302169	0.302169	NUM
dpc-4148	127	33	tlr3	tlr3	VERB
dpc-4148	127	34	2.68	2.68	NUM
dpc-4148	127	35	0.177272	0.177272	NUM
dpc-4148	127	36	2.41	2.41	NUM
dpc-4148	127	37	0.292930	0.292930	NUM
dpc-4148	127	38	tlr4	tlr4	NOUN
dpc-4148	127	39	-1.03	-1.03	NUM
dpc-4148	127	40	0.147965	0.147965	NUM
dpc-4148	127	41	-1.56	-1.56	NUM
dpc-4148	127	42	0.113440	0.113440	NUM
dpc-4148	127	43	tlr5	tlr5	PROPN
dpc-4148	127	44	-2.05	-2.05	ADJ
dpc-4148	127	45	0.380609	0.380609	NUM
dpc-4148	127	46	-3.01	-3.01	VERB
dpc-4148	127	47	0.173864	0.173864	NUM
dpc-4148	127	48	tlr6	tlr6	PROPN
dpc-4148	127	49	2.57	2.57	NUM
dpc-4148	127	50	0.291077	0.291077	NUM
dpc-4148	127	51	-1.11	-1.11	PRON
dpc-4148	127	52	0.399988	0.399988	NUM
dpc-4148	127	53	tlr7	tlr7	NOUN
dpc-4148	127	54	-1.03	-1.03	NUM
dpc-4148	127	55	0.308964	0.308964	NUM
dpc-4148	127	56	-2.62	-2.62	NUM
dpc-4148	127	57	0.510245	0.510245	NUM
dpc-4148	127	58	tlr8	tlr8	NOUN
dpc-4148	127	59	6.10	6.10	NUM
dpc-4148	127	60	0.242098	0.242098	NUM
dpc-4148	127	61	19.48	19.48	NUM
dpc-4148	127	62	0.076069	0.076069	NUM
dpc-4148	127	63	tlr9	tlr9	NOUN
dpc-4148	127	64	2.52	2.52	NUM
dpc-4148	127	65	0.320951	0.320951	NUM
dpc-4148	127	66	2.18	2.18	NUM
dpc-4148	127	67	0.189571	0.189571	NUM
dpc-4148	127	68	tlr10	tlr10	PROPN
dpc-4148	127	69	2.31	2.31	NUM
dpc-4148	127	70	0.872163	0.872163	NUM
dpc-4148	127	71	1.26	1.26	NUM
dpc-4148	127	72	0.710009	0.710009	NUM
dpc-4148	127	73	table	table	NOUN
dpc-4148	127	74	4	4	NUM
dpc-4148	127	75	.	.	PUNCT
dpc-4148	127	76	comparison	comparison	NOUN
dpc-4148	127	77	of	of	ADP
dpc-4148	127	78	serum	serum	PROPN
dpc-4148	127	79	il-6	il-6	NOUN
dpc-4148	127	80	,	,	PUNCT
dpc-4148	127	81	il-17a	il-17a	PROPN
dpc-4148	127	82	,	,	PUNCT
dpc-4148	127	83	fgf	fgf	PROPN
dpc-4148	127	84	,	,	PUNCT
dpc-4148	127	85	vegf	vegf	PROPN
dpc-4148	127	86	,	,	PUNCT
dpc-4148	127	87	and	and	CCONJ
dpc-4148	127	88	tgf	tgf	PROPN
dpc-4148	127	89	-	-	PUNCT
dpc-4148	127	90	β	β	PROPN
dpc-4148	127	91	levels	level	NOUN
dpc-4148	127	92	between	between	ADP
dpc-4148	127	93	groups	group	NOUN
dpc-4148	127	94	.	.	PUNCT
dpc-4148	128	1	patients	patient	NOUN
dpc-4148	128	2	(	(	PUNCT
dpc-4148	128	3	n=15	n=15	NUM
dpc-4148	128	4	)	)	PUNCT
dpc-4148	128	5	healthy	healthy	ADJ
dpc-4148	128	6	controls	control	NOUN
dpc-4148	128	7	(	(	PUNCT
dpc-4148	128	8	n=11	n=11	NOUN
dpc-4148	128	9	)	)	PUNCT
dpc-4148	128	10	p	p	NOUN
dpc-4148	128	11	-	-	PUNCT
dpc-4148	128	12	value	value	NOUN
dpc-4148	128	13	*	*	X
dpc-4148	128	14	il-6	il-6	NOUN
dpc-4148	128	15	200.74±7.94†	200.74±7.94†	NOUN
dpc-4148	128	16	173.54±6.96†	173.54±6.96†	NOUN
dpc-4148	128	17	0.944	0.944	NUM
dpc-4148	128	18	il-17a	il-17a	PROPN
dpc-4148	128	19	277.71±15.9†	277.71±15.9†	PROPN
dpc-4148	128	20	209.11±2.25†	209.11±2.25†	PROPN
dpc-4148	128	21	0.109	0.109	NUM
dpc-4148	128	22	fgf	fgf	PROPN
dpc-4148	128	23	1503.18±83.4†	1503.18±83.4†	NUM
dpc-4148	128	24	1096.16±	1096.16±	NUM
dpc-4148	128	25	25.73†	25.73†	NUM
dpc-4148	128	26	0.293	0.293	NUM
dpc-4148	128	27	vegf	vegf	NOUN
dpc-4148	128	28	1568.44±	1568.44±	NUM
dpc-4148	128	29	82.16†	82.16†	NUM
dpc-4148	128	30	1202.41±	1202.41±	NUM
dpc-4148	128	31	37.15†	37.15†	NUM
dpc-4148	128	32	0.25	0.25	NUM
dpc-4148	128	33	tgfβ	tgfβ	ADJ
dpc-4148	128	34	1138.37±62.01†	1138.37±62.01†	PROPN
dpc-4148	128	35	771.37±24.36†	771.37±24.36†	NUM
dpc-4148	128	36	0.624	0.624	NUM
dpc-4148	128	37	although	although	SCONJ
dpc-4148	128	38	described	describe	VERB
dpc-4148	128	39	as	as	ADP
dpc-4148	128	40	an	an	DET
dpc-4148	128	41	anti	anti	ADJ
dpc-4148	128	42	-	-	ADJ
dpc-4148	128	43	inflammatory	inflammatory	ADJ
dpc-4148	128	44	cytokine	cytokine	NOUN
dpc-4148	128	45	,	,	PUNCT
dpc-4148	128	46	tgf	tgf	PROPN
dpc-4148	128	47	-	-	PUNCT
dpc-4148	128	48	beta	beta	NOUN
dpc-4148	128	49	is	be	AUX
dpc-4148	128	50	a	a	DET
dpc-4148	128	51	profibrotic	profibrotic	ADJ
dpc-4148	128	52	cytokine	cytokine	NOUN
dpc-4148	128	53	in	in	ADP
dpc-4148	128	54	the	the	DET
dpc-4148	128	55	generation	generation	NOUN
dpc-4148	128	56	of	of	ADP
dpc-4148	128	57	morphea	morphea	PROPN
dpc-4148	128	58	.	.	PUNCT
dpc-4148	129	1	there	there	PRON
dpc-4148	129	2	are	be	VERB
dpc-4148	129	3	contradictory	contradictory	ADJ
dpc-4148	129	4	reports	report	NOUN
dpc-4148	129	5	related	relate	VERB
dpc-4148	129	6	to	to	PART
dpc-4148	129	7	serum	serum	VERB
dpc-4148	129	8	tgf	tgf	PROPN
dpc-4148	129	9	-	-	PUNCT
dpc-4148	129	10	beta	beta	NOUN
dpc-4148	129	11	levels	level	NOUN
dpc-4148	129	12	in	in	ADP
dpc-4148	129	13	patients	patient	NOUN
dpc-4148	129	14	with	with	ADP
dpc-4148	129	15	morphea	morphea	PROPN
dpc-4148	129	16	.	.	PUNCT
dpc-4148	130	1	however	however	ADV
dpc-4148	130	2	,	,	PUNCT
dpc-4148	130	3	the	the	DET
dpc-4148	130	4	important	important	ADJ
dpc-4148	130	5	point	point	NOUN
dpc-4148	130	6	here	here	ADV
dpc-4148	130	7	is	be	AUX
dpc-4148	130	8	the	the	DET
dpc-4148	130	9	stage	stage	NOUN
dpc-4148	130	10	of	of	ADP
dpc-4148	130	11	the	the	DET
dpc-4148	130	12	disease	disease	NOUN
dpc-4148	130	13	.	.	PUNCT
dpc-4148	131	1	in	in	ADP
dpc-4148	131	2	our	our	PRON
dpc-4148	131	3	study	study	NOUN
dpc-4148	131	4	,	,	PUNCT
dpc-4148	131	5	our	our	PRON
dpc-4148	131	6	morphea	morphea	NOUN
dpc-4148	131	7	patients	patient	NOUN
dpc-4148	131	8	were	be	AUX
dpc-4148	131	9	selected	select	VERB
dpc-4148	131	10	in	in	ADP
dpc-4148	131	11	the	the	DET
dpc-4148	131	12	inflammatory	inflammatory	ADJ
dpc-4148	131	13	phase	phase	NOUN
dpc-4148	131	14	,	,	PUNCT
dpc-4148	131	15	in	in	ADP
dpc-4148	131	16	which	which	DET
dpc-4148	131	17	phase	phase	NOUN
dpc-4148	131	18	lesions	lesion	NOUN
dpc-4148	131	19	appear	appear	VERB
dpc-4148	131	20	acutely	acutely	ADV
dpc-4148	131	21	.	.	PUNCT
dpc-4148	132	1	the	the	DET
dpc-4148	132	2	tgf	tgf	PROPN
dpc-4148	132	3	-	-	PUNCT
dpc-4148	132	4	β1	β1	PROPN
dpc-4148	132	5	levels	level	NOUN
dpc-4148	132	6	in	in	ADP
dpc-4148	132	7	serum	serum	NOUN
dpc-4148	132	8	samples	sample	NOUN
dpc-4148	132	9	of	of	ADP
dpc-4148	132	10	morphea	morphea	ADJ
dpc-4148	132	11	patients	patient	NOUN
dpc-4148	132	12	at	at	ADP
dpc-4148	132	13	inflammatory	inflammatory	ADJ
dpc-4148	132	14	6	6	NUM
dpc-4148	132	15	original	original	ADJ
dpc-4148	132	16	article	article	NOUN
dpc-4148	132	17	|	|	ADV
dpc-4148	132	18	dermatol	dermatol	ADJ
dpc-4148	132	19	pract	pract	NOUN
dpc-4148	132	20	concept	concept	NOUN
dpc-4148	132	21	.	.	PUNCT
dpc-4148	133	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	133	2	stage	stage	NOUN
dpc-4148	133	3	were	be	AUX
dpc-4148	133	4	determined	determine	VERB
dpc-4148	133	5	as	as	ADP
dpc-4148	133	6	1138.37	1138.37	NUM
dpc-4148	133	7	±	±	NOUN
dpc-4148	133	8	62.01	62.01	NUM
dpc-4148	133	9	ng	ng	PROPN
dpc-4148	133	10	/	/	SYM
dpc-4148	133	11	l.	l.	PROPN
dpc-4148	133	12	this	this	DET
dpc-4148	133	13	value	value	NOUN
dpc-4148	133	14	is	be	AUX
dpc-4148	133	15	statistically	statistically	ADV
dpc-4148	133	16	significant	significant	ADJ
dpc-4148	133	17	,	,	PUNCT
dpc-4148	133	18	with	with	ADP
dpc-4148	133	19	an	an	DET
dpc-4148	133	20	increase	increase	NOUN
dpc-4148	133	21	of	of	ADP
dpc-4148	133	22	approximately	approximately	ADV
dpc-4148	133	23	48	48	NUM
dpc-4148	133	24	%	%	NOUN
dpc-4148	133	25	compared	compare	VERB
dpc-4148	133	26	to	to	ADP
dpc-4148	133	27	the	the	DET
dpc-4148	133	28	levels	level	NOUN
dpc-4148	133	29	of	of	ADP
dpc-4148	133	30	771.37	771.37	NUM
dpc-4148	133	31	±	±	NUM
dpc-4148	133	32	24.36	24.36	NUM
dpc-4148	133	33	ng	ng	PROPN
dpc-4148	133	34	/	/	SYM
dpc-4148	133	35	l	l	PROPN
dpc-4148	133	36	measured	measure	VERB
dpc-4148	133	37	in	in	ADP
dpc-4148	133	38	healthy	healthy	ADJ
dpc-4148	133	39	individuals	individual	NOUN
dpc-4148	133	40	(	(	PUNCT
dpc-4148	133	41	p<0.01	p<0.01	PROPN
dpc-4148	133	42	)	)	PUNCT
dpc-4148	133	43	(	(	PUNCT
dpc-4148	133	44	fig	fig	NOUN
dpc-4148	133	45	.	.	PUNCT
dpc-4148	134	1	5	5	NUM
dpc-4148	134	2	)	)	PUNCT
dpc-4148	134	3	.	.	PUNCT
dpc-4148	135	1	discussion	discussion	NOUN
dpc-4148	135	2	in	in	ADP
dpc-4148	135	3	this	this	DET
dpc-4148	135	4	study	study	NOUN
dpc-4148	135	5	,	,	PUNCT
dpc-4148	135	6	we	we	PRON
dpc-4148	135	7	showed	show	VERB
dpc-4148	135	8	that	that	SCONJ
dpc-4148	135	9	tlr1	tlr1	PROPN
dpc-4148	135	10	gene	gene	NOUN
dpc-4148	135	11	expression	expression	NOUN
dpc-4148	135	12	increased	increase	VERB
dpc-4148	135	13	34.3	34.3	NUM
dpc-4148	135	14	-	-	NOUN
dpc-4148	135	15	fold	fold	ADJ
dpc-4148	135	16	in	in	ADP
dpc-4148	135	17	the	the	DET
dpc-4148	135	18	lesional	lesional	ADJ
dpc-4148	135	19	skin	skin	NOUN
dpc-4148	135	20	of	of	ADP
dpc-4148	135	21	patients	patient	NOUN
dpc-4148	135	22	with	with	ADP
dpc-4148	135	23	morphea	morphea	PROPN
dpc-4148	135	24	.	.	PUNCT
dpc-4148	136	1	in	in	ADP
dpc-4148	136	2	addition	addition	NOUN
dpc-4148	136	3	,	,	PUNCT
dpc-4148	136	4	il	il	PROPN
dpc-4148	136	5	-6	-6	PROPN
dpc-4148	136	6	,	,	PUNCT
dpc-4148	136	7	il	il	PROPN
dpc-4148	136	8	-17a	-17a	PROPN
dpc-4148	136	9	,	,	PUNCT
dpc-4148	136	10	tgf	tgf	PROPN
dpc-4148	136	11	-	-	PUNCT
dpc-4148	136	12	β	β	PROPN
dpc-4148	136	13	,	,	PUNCT
dpc-4148	136	14	fgf	fgf	PROPN
dpc-4148	136	15	,	,	PUNCT
dpc-4148	136	16	and	and	CCONJ
dpc-4148	136	17	vegf	vegf	PROPN
dpc-4148	136	18	were	be	AUX
dpc-4148	136	19	found	find	VERB
dpc-4148	136	20	to	to	PART
dpc-4148	136	21	be	be	AUX
dpc-4148	136	22	higher	high	ADJ
dpc-4148	136	23	in	in	ADP
dpc-4148	136	24	the	the	DET
dpc-4148	136	25	blood	blood	NOUN
dpc-4148	136	26	samples	sample	NOUN
dpc-4148	136	27	of	of	ADP
dpc-4148	136	28	the	the	DET
dpc-4148	136	29	patient	patient	ADJ
dpc-4148	136	30	group	group	NOUN
dpc-4148	136	31	than	than	ADP
dpc-4148	136	32	in	in	ADP
dpc-4148	136	33	the	the	DET
dpc-4148	136	34	healthy	healthy	ADJ
dpc-4148	136	35	group	group	NOUN
dpc-4148	136	36	.	.	PUNCT
dpc-4148	137	1	the	the	DET
dpc-4148	137	2	role	role	NOUN
dpc-4148	137	3	of	of	ADP
dpc-4148	137	4	tlr	tlr	PROPN
dpc-4148	137	5	signaling	signal	VERB
dpc-4148	137	6	in	in	ADP
dpc-4148	137	7	fibroblasts	fibroblast	NOUN
dpc-4148	137	8	is	be	AUX
dpc-4148	137	9	not	not	PART
dpc-4148	137	10	entirely	entirely	ADV
dpc-4148	137	11	clear	clear	ADJ
dpc-4148	137	12	.	.	PUNCT
dpc-4148	138	1	it	it	PRON
dpc-4148	138	2	has	have	AUX
dpc-4148	138	3	been	be	AUX
dpc-4148	138	4	shown	show	VERB
dpc-4148	138	5	that	that	SCONJ
dpc-4148	138	6	different	different	ADJ
dpc-4148	138	7	fibroblast	fibroblast	ADJ
dpc-4148	138	8	populations	population	NOUN
dpc-4148	138	9	can	can	AUX
dpc-4148	138	10	increase	increase	VERB
dpc-4148	138	11	inflammatory	inflammatory	ADJ
dpc-4148	138	12	infiltration	infiltration	NOUN
dpc-4148	138	13	through	through	ADP
dpc-4148	138	14	increased	increase	VERB
dpc-4148	138	15	chemokine	chemokine	ADJ
dpc-4148	138	16	and	and	CCONJ
dpc-4148	138	17	cytokine	cytokine	ADJ
dpc-4148	138	18	production	production	NOUN
dpc-4148	138	19	as	as	ADP
dpc-4148	138	20	a	a	DET
dpc-4148	138	21	result	result	NOUN
dpc-4148	138	22	of	of	ADP
dpc-4148	138	23	figure	figure	NOUN
dpc-4148	138	24	1	1	NUM
dpc-4148	138	25	.	.	PUNCT
dpc-4148	138	26	serum	serum	PROPN
dpc-4148	138	27	il-17a	il-17a	PROPN
dpc-4148	138	28	levels	level	NOUN
dpc-4148	138	29	in	in	ADP
dpc-4148	138	30	healthy	healthy	ADJ
dpc-4148	138	31	individuals	individual	NOUN
dpc-4148	138	32	and	and	CCONJ
dpc-4148	138	33	morphea	morphea	NOUN
dpc-4148	138	34	patients	patient	NOUN
dpc-4148	138	35	.	.	PUNCT
dpc-4148	139	1	data	datum	NOUN
dpc-4148	139	2	are	be	AUX
dpc-4148	139	3	expressed	express	VERB
dpc-4148	139	4	as	as	ADP
dpc-4148	139	5	mean	mean	NOUN
dpc-4148	139	6	of	of	ADP
dpc-4148	139	7	the	the	DET
dpc-4148	139	8	percentages	percentage	NOUN
dpc-4148	139	9	of	of	ADP
dpc-4148	139	10	il-17a	il-17a	PROPN
dpc-4148	139	11	levels	level	NOUN
dpc-4148	139	12	±	±	PROPN
dpc-4148	139	13	sem	sem	NOUN
dpc-4148	139	14	of	of	ADP
dpc-4148	139	15	3	3	NUM
dpc-4148	139	16	experiments	experiment	NOUN
dpc-4148	139	17	(	(	PUNCT
dpc-4148	139	18	*	*	PUNCT
dpc-4148	139	19	p	p	X
dpc-4148	139	20	<	<	X
dpc-4148	139	21	0.05	0.05	NUM
dpc-4148	139	22	versus	versus	ADP
dpc-4148	139	23	healthy	healthy	ADJ
dpc-4148	139	24	group	group	NOUN
dpc-4148	139	25	)	)	PUNCT
dpc-4148	139	26	.	.	PUNCT
dpc-4148	140	1	figure	figure	NOUN
dpc-4148	140	2	2	2	NUM
dpc-4148	140	3	.	.	PUNCT
dpc-4148	141	1	serum	serum	PROPN
dpc-4148	141	2	il-6	il-6	NOUN
dpc-4148	141	3	levels	level	NOUN
dpc-4148	141	4	in	in	ADP
dpc-4148	141	5	healthy	healthy	ADJ
dpc-4148	141	6	individuals	individual	NOUN
dpc-4148	141	7	and	and	CCONJ
dpc-4148	141	8	morphea	morphea	NOUN
dpc-4148	141	9	patients	patient	NOUN
dpc-4148	141	10	.	.	PUNCT
dpc-4148	142	1	data	datum	NOUN
dpc-4148	142	2	are	be	AUX
dpc-4148	142	3	given	give	VERB
dpc-4148	142	4	as	as	ADP
dpc-4148	142	5	mean	mean	PROPN
dpc-4148	142	6	±	±	NUM
dpc-4148	142	7	sem	sem	NOUN
dpc-4148	142	8	of	of	ADP
dpc-4148	142	9	three	three	NUM
dpc-4148	142	10	experiments	experiment	NOUN
dpc-4148	142	11	.	.	PUNCT
dpc-4148	143	1	figure	figure	NOUN
dpc-4148	143	2	3	3	NUM
dpc-4148	143	3	.	.	PUNCT
dpc-4148	143	4	serum	serum	PROPN
dpc-4148	143	5	fgf	fgf	PROPN
dpc-4148	143	6	levels	level	NOUN
dpc-4148	143	7	in	in	ADP
dpc-4148	143	8	healthy	healthy	ADJ
dpc-4148	143	9	individuals	individual	NOUN
dpc-4148	143	10	and	and	CCONJ
dpc-4148	143	11	morphea	morphea	NOUN
dpc-4148	143	12	patients	patient	NOUN
dpc-4148	143	13	.	.	PUNCT
dpc-4148	144	1	data	datum	NOUN
dpc-4148	144	2	are	be	AUX
dpc-4148	144	3	expressed	express	VERB
dpc-4148	144	4	as	as	ADP
dpc-4148	144	5	mean	mean	NOUN
dpc-4148	144	6	of	of	ADP
dpc-4148	144	7	the	the	DET
dpc-4148	144	8	percentages	percentage	NOUN
dpc-4148	144	9	of	of	ADP
dpc-4148	144	10	fgf	fgf	PROPN
dpc-4148	144	11	levels	levels	PROPN
dpc-4148	144	12	±	±	PROPN
dpc-4148	144	13	sem	sem	NOUN
dpc-4148	144	14	of	of	ADP
dpc-4148	144	15	three	three	NUM
dpc-4148	144	16	experiments	experiment	NOUN
dpc-4148	144	17	(	(	PUNCT
dpc-4148	144	18	*	*	PUNCT
dpc-4148	144	19	p	p	X
dpc-4148	144	20	<	<	X
dpc-4148	144	21	0.05	0.05	NUM
dpc-4148	144	22	versus	versus	ADP
dpc-4148	144	23	healthy	healthy	ADJ
dpc-4148	144	24	group	group	NOUN
dpc-4148	144	25	)	)	PUNCT
dpc-4148	144	26	.	.	PUNCT
dpc-4148	145	1	figure	figure	VERB
dpc-4148	145	2	4	4	NUM
dpc-4148	145	3	.	.	PUNCT
dpc-4148	145	4	serum	serum	PROPN
dpc-4148	145	5	vegf	vegf	PROPN
dpc-4148	145	6	levels	level	NOUN
dpc-4148	145	7	in	in	ADP
dpc-4148	145	8	healthy	healthy	ADJ
dpc-4148	145	9	individuals	individual	NOUN
dpc-4148	145	10	and	and	CCONJ
dpc-4148	145	11	morphea	morphea	NOUN
dpc-4148	145	12	patients	patient	NOUN
dpc-4148	145	13	.	.	PUNCT
dpc-4148	146	1	data	datum	NOUN
dpc-4148	146	2	are	be	AUX
dpc-4148	146	3	expressed	express	VERB
dpc-4148	146	4	as	as	ADP
dpc-4148	146	5	mean	mean	NOUN
dpc-4148	146	6	of	of	ADP
dpc-4148	146	7	the	the	DET
dpc-4148	146	8	percentages	percentage	NOUN
dpc-4148	146	9	of	of	ADP
dpc-4148	146	10	vgf	vgf	PROPN
dpc-4148	146	11	levels	level	NOUN
dpc-4148	146	12	±	±	PROPN
dpc-4148	146	13	sem	sem	NOUN
dpc-4148	146	14	of	of	ADP
dpc-4148	146	15	three	three	NUM
dpc-4148	146	16	experiments	experiment	NOUN
dpc-4148	146	17	(	(	PUNCT
dpc-4148	146	18	*	*	PUNCT
dpc-4148	146	19	p	p	X
dpc-4148	146	20	<	<	X
dpc-4148	146	21	0.05	0.05	NUM
dpc-4148	146	22	versus	versus	ADP
dpc-4148	146	23	healthy	healthy	ADJ
dpc-4148	146	24	group	group	NOUN
dpc-4148	146	25	)	)	PUNCT
dpc-4148	146	26	.	.	PUNCT
dpc-4148	147	1	figure	figure	NOUN
dpc-4148	147	2	5	5	NUM
dpc-4148	147	3	.	.	PUNCT
dpc-4148	147	4	serum	serum	PROPN
dpc-4148	147	5	tgf	tgf	PROPN
dpc-4148	147	6	-	-	PUNCT
dpc-4148	147	7	beta	beta	NOUN
dpc-4148	147	8	levels	level	NOUN
dpc-4148	147	9	in	in	ADP
dpc-4148	147	10	healthy	healthy	ADJ
dpc-4148	147	11	individuals	individual	NOUN
dpc-4148	147	12	and	and	CCONJ
dpc-4148	147	13	morphea	morphea	NOUN
dpc-4148	147	14	patients	patient	NOUN
dpc-4148	147	15	.	.	PUNCT
dpc-4148	148	1	data	datum	NOUN
dpc-4148	148	2	are	be	AUX
dpc-4148	148	3	given	give	VERB
dpc-4148	148	4	as	as	ADP
dpc-4148	148	5	mean	mean	PROPN
dpc-4148	148	6	±	±	NUM
dpc-4148	148	7	sem	sem	NOUN
dpc-4148	148	8	of	of	ADP
dpc-4148	148	9	three	three	NUM
dpc-4148	148	10	experiments	experiment	NOUN
dpc-4148	148	11	(	(	PUNCT
dpc-4148	148	12	*	*	PUNCT
dpc-4148	148	13	p	p	X
dpc-4148	148	14	<	<	X
dpc-4148	148	15	0.05	0.05	NUM
dpc-4148	148	16	versus	versus	ADP
dpc-4148	148	17	healthy	healthy	ADJ
dpc-4148	148	18	group	group	NOUN
dpc-4148	148	19	)	)	PUNCT
dpc-4148	148	20	.	.	PUNCT
dpc-4148	149	1	original	original	ADJ
dpc-4148	149	2	article	article	NOUN
dpc-4148	149	3	|	|	ADV
dpc-4148	149	4	dermatol	dermatol	ADJ
dpc-4148	149	5	pract	pract	NOUN
dpc-4148	149	6	concept	concept	NOUN
dpc-4148	149	7	.	.	PUNCT
dpc-4148	150	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	150	2	7	7	NUM
dpc-4148	150	3	systemic	systemic	NOUN
dpc-4148	150	4	)	)	PUNCT
dpc-4148	150	5	or	or	CCONJ
dpc-4148	150	6	the	the	DET
dpc-4148	150	7	duration	duration	NOUN
dpc-4148	150	8	of	of	ADP
dpc-4148	150	9	the	the	DET
dpc-4148	150	10	disease	disease	NOUN
dpc-4148	150	11	in	in	ADP
dpc-4148	150	12	our	our	PRON
dpc-4148	150	13	morphea	morphea	ADJ
dpc-4148	150	14	patients	patient	NOUN
dpc-4148	150	15	.	.	PUNCT
dpc-4148	151	1	tlr-2	tlr-2	PRON
dpc-4148	151	2	has	have	AUX
dpc-4148	151	3	been	be	AUX
dpc-4148	151	4	found	find	VERB
dpc-4148	151	5	to	to	PART
dpc-4148	151	6	be	be	AUX
dpc-4148	151	7	overexpressed	overexpresse	VERB
dpc-4148	151	8	in	in	ADP
dpc-4148	151	9	fibroblasts	fibroblast	NOUN
dpc-4148	151	10	of	of	ADP
dpc-4148	151	11	systemic	systemic	ADJ
dpc-4148	151	12	sclerosis	sclerosis	NOUN
dpc-4148	151	13	,	,	PUNCT
dpc-4148	151	14	which	which	PRON
dpc-4148	151	15	produce	produce	VERB
dpc-4148	151	16	a	a	DET
dpc-4148	151	17	large	large	ADJ
dpc-4148	151	18	amount	amount	NOUN
dpc-4148	151	19	of	of	ADP
dpc-4148	151	20	il-6	il-6	NOUN
dpc-4148	151	21	and	and	CCONJ
dpc-4148	151	22	lead	lead	VERB
dpc-4148	151	23	to	to	ADP
dpc-4148	151	24	fibrosis	fibrosis	NOUN
dpc-4148	151	25	[	[	X
dpc-4148	151	26	30	30	NUM
dpc-4148	151	27	]	]	PUNCT
dpc-4148	151	28	.	.	PUNCT
dpc-4148	152	1	in	in	ADP
dpc-4148	152	2	addition	addition	NOUN
dpc-4148	152	3	,	,	PUNCT
dpc-4148	152	4	tlr-2	tlr-2	PRON
dpc-4148	152	5	interacts	interact	VERB
dpc-4148	152	6	with	with	ADP
dpc-4148	152	7	tlr1	tlr1	NOUN
dpc-4148	152	8	and	and	CCONJ
dpc-4148	152	9	tlr6	tlr6	PROPN
dpc-4148	152	10	and	and	CCONJ
dpc-4148	152	11	forms	form	NOUN
dpc-4148	152	12	heterodimers	heterodimer	NOUN
dpc-4148	152	13	to	to	PART
dpc-4148	152	14	recognize	recognize	VERB
dpc-4148	152	15	a	a	DET
dpc-4148	152	16	variety	variety	NOUN
dpc-4148	152	17	of	of	ADP
dpc-4148	152	18	pathogen	pathogen	NOUN
dpc-4148	152	19	-	-	PUNCT
dpc-4148	152	20	associated	associate	VERB
dpc-4148	152	21	molecular	molecular	ADJ
dpc-4148	152	22	patterns	pattern	NOUN
dpc-4148	152	23	(	(	PUNCT
dpc-4148	152	24	pamps	pamp	NOUN
dpc-4148	152	25	)	)	PUNCT
dpc-4148	152	26	.	.	PUNCT
dpc-4148	153	1	in	in	ADP
dpc-4148	153	2	our	our	PRON
dpc-4148	153	3	study	study	NOUN
dpc-4148	153	4	,	,	PUNCT
dpc-4148	153	5	we	we	PRON
dpc-4148	153	6	found	find	VERB
dpc-4148	153	7	overexpression	overexpression	NOUN
dpc-4148	153	8	of	of	ADP
dpc-4148	153	9	tlr1	tlr1	NOUN
dpc-4148	153	10	and	and	CCONJ
dpc-4148	153	11	tlr2	tlr2	VERB
dpc-4148	153	12	in	in	ADP
dpc-4148	153	13	the	the	DET
dpc-4148	153	14	patient	patient	NOUN
dpc-4148	153	15	group	group	NOUN
dpc-4148	153	16	,	,	PUNCT
dpc-4148	153	17	with	with	ADP
dpc-4148	153	18	only	only	ADJ
dpc-4148	153	19	tlr1	tlr1	PROPN
dpc-4148	153	20	being	be	AUX
dpc-4148	153	21	significant	significant	ADJ
dpc-4148	153	22	.	.	PUNCT
dpc-4148	154	1	the	the	DET
dpc-4148	154	2	expression	expression	NOUN
dpc-4148	154	3	of	of	ADP
dpc-4148	154	4	tlr-5	tlr-5	NUM
dpc-4148	154	5	and	and	CCONJ
dpc-4148	154	6	tlr-10	tlr-10	PRON
dpc-4148	154	7	was	be	AUX
dpc-4148	154	8	also	also	ADV
dpc-4148	154	9	upregulated	upregulate	VERB
dpc-4148	154	10	in	in	ADP
dpc-4148	154	11	fibroblasts	fibroblast	NOUN
dpc-4148	154	12	of	of	ADP
dpc-4148	154	13	systemic	systemic	ADJ
dpc-4148	154	14	sclerosis	sclerosis	NOUN
dpc-4148	154	15	[	[	X
dpc-4148	154	16	31	31	NUM
dpc-4148	154	17	]	]	PUNCT
dpc-4148	154	18	.	.	PUNCT
dpc-4148	155	1	however	however	ADV
dpc-4148	155	2	,	,	PUNCT
dpc-4148	155	3	the	the	DET
dpc-4148	155	4	authors	author	NOUN
dpc-4148	155	5	claimed	claim	VERB
dpc-4148	155	6	that	that	SCONJ
dpc-4148	155	7	tlr-5	tlr-5	NUM
dpc-4148	155	8	may	may	AUX
dpc-4148	155	9	have	have	VERB
dpc-4148	155	10	a	a	DET
dpc-4148	155	11	suppressive	suppressive	ADJ
dpc-4148	155	12	effect	effect	NOUN
dpc-4148	155	13	on	on	ADP
dpc-4148	155	14	collagen	collagen	NOUN
dpc-4148	155	15	expression	expression	NOUN
dpc-4148	155	16	and	and	CCONJ
dpc-4148	155	17	play	play	VERB
dpc-4148	155	18	a	a	DET
dpc-4148	155	19	role	role	NOUN
dpc-4148	155	20	in	in	ADP
dpc-4148	155	21	regulating	regulate	VERB
dpc-4148	155	22	fibrosis	fibrosis	NOUN
dpc-4148	155	23	.	.	PUNCT
dpc-4148	156	1	in	in	ADP
dpc-4148	156	2	support	support	NOUN
dpc-4148	156	3	of	of	ADP
dpc-4148	156	4	this	this	PRON
dpc-4148	156	5	,	,	PUNCT
dpc-4148	156	6	it	it	PRON
dpc-4148	156	7	has	have	AUX
dpc-4148	156	8	been	be	AUX
dpc-4148	156	9	reported	report	VERB
dpc-4148	156	10	that	that	SCONJ
dpc-4148	156	11	triggering	trigger	VERB
dpc-4148	156	12	tlr-5	tlr-5	NUM
dpc-4148	156	13	by	by	ADP
dpc-4148	156	14	pamp	pamp	NOUN
dpc-4148	156	15	flagellin	flagellin	NOUN
dpc-4148	156	16	can	can	AUX
dpc-4148	156	17	prevent	prevent	VERB
dpc-4148	156	18	collagen	collagen	NOUN
dpc-4148	156	19	deposition	deposition	NOUN
dpc-4148	156	20	in	in	ADP
dpc-4148	156	21	cultured	cultured	ADJ
dpc-4148	156	22	fibroblasts	fibroblast	NOUN
dpc-4148	156	23	in	in	ADP
dpc-4148	156	24	vitro	vitro	X
dpc-4148	157	1	[	[	X
dpc-4148	157	2	31	31	NUM
dpc-4148	157	3	]	]	PUNCT
dpc-4148	157	4	.	.	PUNCT
dpc-4148	158	1	one	one	NUM
dpc-4148	158	2	study	study	NOUN
dpc-4148	158	3	showed	show	VERB
dpc-4148	158	4	that	that	SCONJ
dpc-4148	158	5	high	high	ADJ
dpc-4148	158	6	mobility	mobility	NOUN
dpc-4148	158	7	group	group	NOUN
dpc-4148	158	8	protein	protein	NOUN
dpc-4148	158	9	1	1	NUM
dpc-4148	158	10	(	(	PUNCT
dpc-4148	158	11	hmgb1	hmgb1	PROPN
dpc-4148	158	12	)	)	PUNCT
dpc-4148	158	13	,	,	PUNCT
dpc-4148	158	14	an	an	DET
dpc-4148	158	15	agonist	agonist	NOUN
dpc-4148	158	16	of	of	ADP
dpc-4148	158	17	tlr-5	tlr-5	NUM
dpc-4148	158	18	,	,	PUNCT
dpc-4148	158	19	interacts	interact	VERB
dpc-4148	158	20	with	with	ADP
dpc-4148	158	21	tlr5	tlr5	NOUN
dpc-4148	158	22	and	and	CCONJ
dpc-4148	158	23	causes	cause	VERB
dpc-4148	158	24	the	the	DET
dpc-4148	158	25	induction	induction	NOUN
dpc-4148	158	26	of	of	ADP
dpc-4148	158	27	signaling	signal	VERB
dpc-4148	158	28	that	that	PRON
dpc-4148	158	29	activates	activate	VERB
dpc-4148	158	30	myd88	myd88	PROPN
dpc-4148	158	31	and	and	CCONJ
dpc-4148	158	32	nuclear	nuclear	ADJ
dpc-4148	158	33	factor	factor	NOUN
dpc-4148	158	34	kappa	kappa	PROPN
dpc-4148	158	35	b	b	PROPN
dpc-4148	158	36	(	(	PUNCT
dpc-4148	158	37	nf	nf	PROPN
dpc-4148	158	38	-	-	PUNCT
dpc-4148	158	39	kb	kb	NOUN
dpc-4148	158	40	)	)	PUNCT
dpc-4148	159	1	[	[	X
dpc-4148	159	2	32	32	NUM
dpc-4148	159	3	]	]	PUNCT
dpc-4148	159	4	.	.	PUNCT
dpc-4148	160	1	accordingly	accordingly	ADV
dpc-4148	160	2	,	,	PUNCT
dpc-4148	160	3	these	these	DET
dpc-4148	160	4	results	result	NOUN
dpc-4148	160	5	may	may	AUX
dpc-4148	160	6	show	show	VERB
dpc-4148	160	7	that	that	SCONJ
dpc-4148	160	8	damage	damage	NOUN
dpc-4148	160	9	associated	associate	VERB
dpc-4148	160	10	moleculer	moleculer	NOUN
dpc-4148	160	11	patterns	pattern	NOUN
dpc-4148	160	12	(	(	PUNCT
dpc-4148	160	13	damps	damps	PROPN
dpc-4148	160	14	)	)	PUNCT
dpc-4148	160	15	other	other	ADJ
dpc-4148	160	16	than	than	ADP
dpc-4148	160	17	flagellin	flagellin	NOUN
dpc-4148	160	18	or	or	CCONJ
dpc-4148	160	19	other	other	ADJ
dpc-4148	160	20	pambs	pamb	NOUN
dpc-4148	160	21	induce	induce	VERB
dpc-4148	160	22	the	the	DET
dpc-4148	160	23	fibrosis	fibrosis	NOUN
dpc-4148	160	24	process	process	NOUN
dpc-4148	160	25	via	via	ADP
dpc-4148	160	26	tlr5	tlr5	ADJ
dpc-4148	160	27	induction	induction	NOUN
dpc-4148	160	28	in	in	ADP
dpc-4148	160	29	systemic	systemic	ADJ
dpc-4148	160	30	scleroderma	scleroderma	NOUN
dpc-4148	160	31	.	.	PUNCT
dpc-4148	161	1	however	however	ADV
dpc-4148	161	2	,	,	PUNCT
dpc-4148	161	3	in	in	ADP
dpc-4148	161	4	our	our	PRON
dpc-4148	161	5	study	study	NOUN
dpc-4148	161	6	,	,	PUNCT
dpc-4148	161	7	we	we	PRON
dpc-4148	161	8	did	do	AUX
dpc-4148	161	9	not	not	PART
dpc-4148	161	10	detect	detect	VERB
dpc-4148	161	11	any	any	DET
dpc-4148	161	12	upregulation	upregulation	NOUN
dpc-4148	161	13	of	of	ADP
dpc-4148	161	14	tlr5	tlr5	NOUN
dpc-4148	161	15	expression	expression	NOUN
dpc-4148	161	16	.	.	PUNCT
dpc-4148	162	1	tlr-10	tlr-10	PRON
dpc-4148	162	2	has	have	VERB
dpc-4148	162	3	an	an	DET
dpc-4148	162	4	anti	anti	ADJ
dpc-4148	162	5	-	-	ADJ
dpc-4148	162	6	inflammatory	inflammatory	ADJ
dpc-4148	162	7	function	function	NOUN
dpc-4148	162	8	after	after	ADP
dpc-4148	162	9	forming	form	VERB
dpc-4148	162	10	heterodimers	heterodimer	NOUN
dpc-4148	162	11	with	with	ADP
dpc-4148	162	12	tlr-2	tlr-2	NUM
dpc-4148	162	13	.	.	PUNCT
dpc-4148	163	1	it	it	PRON
dpc-4148	163	2	has	have	VERB
dpc-4148	163	3	receptors	receptor	NOUN
dpc-4148	163	4	on	on	ADP
dpc-4148	163	5	both	both	DET
dpc-4148	163	6	b	b	NOUN
dpc-4148	163	7	cells	cell	NOUN
dpc-4148	163	8	and	and	CCONJ
dpc-4148	163	9	plasmacytoid	plasmacytoid	VERB
dpc-4148	163	10	dendritic	dendritic	ADJ
dpc-4148	163	11	cells	cell	NOUN
dpc-4148	163	12	(	(	PUNCT
dpc-4148	163	13	pdcs	pdcs	PROPN
dpc-4148	163	14	)	)	PUNCT
dpc-4148	163	15	and	and	CCONJ
dpc-4148	163	16	activates	activate	VERB
dpc-4148	163	17	gene	gene	NOUN
dpc-4148	163	18	transcription	transcription	NOUN
dpc-4148	163	19	through	through	ADP
dpc-4148	163	20	myd88	myd88	PROPN
dpc-4148	164	1	[	[	X
dpc-4148	164	2	33	33	NUM
dpc-4148	164	3	]	]	PUNCT
dpc-4148	164	4	.	.	PUNCT
dpc-4148	165	1	tlr-10	tlr-10	PRON
dpc-4148	165	2	is	be	AUX
dpc-4148	165	3	thought	think	VERB
dpc-4148	165	4	to	to	PART
dpc-4148	165	5	play	play	VERB
dpc-4148	165	6	a	a	DET
dpc-4148	165	7	crucial	crucial	ADJ
dpc-4148	165	8	role	role	NOUN
dpc-4148	165	9	in	in	ADP
dpc-4148	165	10	regulating	regulate	VERB
dpc-4148	165	11	the	the	DET
dpc-4148	165	12	ifn	ifn	PROPN
dpc-4148	165	13	-	-	PUNCT
dpc-4148	165	14	i	i	NOUN
dpc-4148	165	15	signaling	signal	VERB
dpc-4148	165	16	pathway	pathway	NOUN
dpc-4148	165	17	by	by	ADP
dpc-4148	165	18	sequestering	sequester	VERB
dpc-4148	165	19	dsrna	dsrna	NOUN
dpc-4148	165	20	from	from	ADP
dpc-4148	165	21	tlr-3	tlr-3	PRON
dpc-4148	165	22	[	[	X
dpc-4148	165	23	34	34	NUM
dpc-4148	165	24	]	]	PUNCT
dpc-4148	165	25	.	.	PUNCT
dpc-4148	166	1	in	in	ADP
dpc-4148	166	2	our	our	PRON
dpc-4148	166	3	study	study	NOUN
dpc-4148	166	4	,	,	PUNCT
dpc-4148	166	5	we	we	PRON
dpc-4148	166	6	found	find	VERB
dpc-4148	166	7	a	a	DET
dpc-4148	166	8	higher	high	ADJ
dpc-4148	166	9	expression	expression	NOUN
dpc-4148	166	10	of	of	ADP
dpc-4148	166	11	tlr-10	tlr-10	NUM
dpc-4148	166	12	in	in	ADP
dpc-4148	166	13	the	the	DET
dpc-4148	166	14	patient	patient	NOUN
dpc-4148	166	15	group	group	NOUN
dpc-4148	166	16	,	,	PUNCT
dpc-4148	166	17	and	and	CCONJ
dpc-4148	166	18	although	although	SCONJ
dpc-4148	166	19	this	this	DET
dpc-4148	166	20	difference	difference	NOUN
dpc-4148	166	21	was	be	AUX
dpc-4148	166	22	not	not	PART
dpc-4148	166	23	significant	significant	ADJ
dpc-4148	166	24	,	,	PUNCT
dpc-4148	166	25	it	it	PRON
dpc-4148	166	26	may	may	AUX
dpc-4148	166	27	be	be	AUX
dpc-4148	166	28	related	relate	VERB
dpc-4148	166	29	to	to	ADP
dpc-4148	166	30	the	the	DET
dpc-4148	166	31	balance	balance	NOUN
dpc-4148	166	32	of	of	ADP
dpc-4148	166	33	the	the	DET
dpc-4148	166	34	inflammatory	inflammatory	ADJ
dpc-4148	166	35	process	process	NOUN
dpc-4148	166	36	in	in	ADP
dpc-4148	166	37	patients	patient	NOUN
dpc-4148	166	38	with	with	ADP
dpc-4148	166	39	morphea	morphea	PROPN
dpc-4148	166	40	.	.	PUNCT
dpc-4148	167	1	fang	fang	PROPN
dpc-4148	167	2	et	et	PROPN
dpc-4148	167	3	al	al	PROPN
dpc-4148	167	4	.	.	PROPN
dpc-4148	167	5	found	find	VERB
dpc-4148	167	6	a	a	DET
dpc-4148	167	7	significantly	significantly	ADV
dpc-4148	167	8	increased	increase	VERB
dpc-4148	167	9	expression	expression	NOUN
dpc-4148	167	10	of	of	ADP
dpc-4148	167	11	the	the	DET
dpc-4148	167	12	tlr-9	tlr-9	NUM
dpc-4148	167	13	gene	gene	NOUN
dpc-4148	167	14	in	in	ADP
dpc-4148	167	15	the	the	DET
dpc-4148	167	16	dermis	dermis	NOUN
dpc-4148	167	17	of	of	ADP
dpc-4148	167	18	patients	patient	NOUN
dpc-4148	167	19	with	with	ADP
dpc-4148	167	20	systemic	systemic	ADJ
dpc-4148	167	21	sclerosis	sclerosis	NOUN
dpc-4148	167	22	compared	compare	VERB
dpc-4148	167	23	to	to	ADP
dpc-4148	167	24	the	the	DET
dpc-4148	167	25	dermis	dermis	NOUN
dpc-4148	167	26	of	of	ADP
dpc-4148	167	27	control	control	NOUN
dpc-4148	167	28	subjects	subject	NOUN
dpc-4148	167	29	.	.	PUNCT
dpc-4148	168	1	in	in	ADP
dpc-4148	168	2	this	this	PRON
dpc-4148	168	3	in	in	ADP
dpc-4148	168	4	vitro	vitro	X
dpc-4148	168	5	study	study	NOUN
dpc-4148	168	6	,	,	PUNCT
dpc-4148	168	7	tlr-9	tlr-9	NUM
dpc-4148	168	8	ligand	ligand	NOUN
dpc-4148	168	9	was	be	AUX
dpc-4148	168	10	shown	show	VERB
dpc-4148	168	11	to	to	PART
dpc-4148	168	12	stimulate	stimulate	VERB
dpc-4148	168	13	a	a	DET
dpc-4148	168	14	profibrotic	profibrotic	ADJ
dpc-4148	168	15	profile	profile	NOUN
dpc-4148	168	16	and	and	CCONJ
dpc-4148	168	17	overproduction	overproduction	NOUN
dpc-4148	168	18	of	of	ADP
dpc-4148	168	19	tgf	tgf	PROPN
dpc-4148	168	20	-	-	PUNCT
dpc-4148	168	21	β	β	NOUN
dpc-4148	169	1	[	[	X
dpc-4148	169	2	35	35	NUM
dpc-4148	169	3	]	]	PUNCT
dpc-4148	169	4	.	.	PUNCT
dpc-4148	170	1	our	our	PRON
dpc-4148	170	2	results	result	NOUN
dpc-4148	170	3	were	be	AUX
dpc-4148	170	4	also	also	ADV
dpc-4148	170	5	in	in	ADP
dpc-4148	170	6	good	good	ADJ
dpc-4148	170	7	agreement	agreement	NOUN
dpc-4148	170	8	with	with	ADP
dpc-4148	170	9	the	the	DET
dpc-4148	170	10	literature	literature	NOUN
dpc-4148	170	11	.	.	PUNCT
dpc-4148	171	1	one	one	NUM
dpc-4148	171	2	study	study	NOUN
dpc-4148	171	3	showed	show	VERB
dpc-4148	171	4	significantly	significantly	ADV
dpc-4148	171	5	increased	increase	VERB
dpc-4148	171	6	tlr7	tlr7	NOUN
dpc-4148	171	7	gene	gene	NOUN
dpc-4148	171	8	expression	expression	NOUN
dpc-4148	171	9	in	in	ADP
dpc-4148	171	10	patients	patient	NOUN
dpc-4148	171	11	with	with	ADP
dpc-4148	171	12	systemic	systemic	ADJ
dpc-4148	171	13	sclerosis	sclerosis	NOUN
dpc-4148	171	14	compared	compare	VERB
dpc-4148	171	15	to	to	ADP
dpc-4148	171	16	a	a	DET
dpc-4148	171	17	healthy	healthy	ADJ
dpc-4148	171	18	group	group	NOUN
dpc-4148	171	19	[	[	X
dpc-4148	171	20	36	36	NUM
dpc-4148	171	21	]	]	PUNCT
dpc-4148	171	22	.	.	PUNCT
dpc-4148	172	1	those	those	DET
dpc-4148	172	2	authors	author	NOUN
dpc-4148	172	3	reported	report	VERB
dpc-4148	172	4	that	that	SCONJ
dpc-4148	172	5	increased	increase	VERB
dpc-4148	172	6	tlr7	tlr7	NOUN
dpc-4148	172	7	expression	expression	NOUN
dpc-4148	172	8	correlated	correlate	VERB
dpc-4148	172	9	positively	positively	ADV
dpc-4148	172	10	with	with	ADP
dpc-4148	172	11	late	late	ADJ
dpc-4148	172	12	-	-	PUNCT
dpc-4148	172	13	onset	onset	NOUN
dpc-4148	172	14	disease	disease	NOUN
dpc-4148	172	15	,	,	PUNCT
dpc-4148	172	16	active	active	ADJ
dpc-4148	172	17	disease	disease	NOUN
dpc-4148	172	18	,	,	PUNCT
dpc-4148	172	19	and	and	CCONJ
dpc-4148	172	20	the	the	DET
dpc-4148	172	21	presence	presence	NOUN
dpc-4148	172	22	of	of	ADP
dpc-4148	172	23	digital	digital	ADJ
dpc-4148	172	24	ulcers	ulcer	NOUN
dpc-4148	172	25	.	.	PUNCT
dpc-4148	173	1	in	in	ADP
dpc-4148	173	2	contrast	contrast	NOUN
dpc-4148	173	3	to	to	ADP
dpc-4148	173	4	the	the	DET
dpc-4148	173	5	literature	literature	NOUN
dpc-4148	173	6	,	,	PUNCT
dpc-4148	173	7	the	the	DET
dpc-4148	173	8	authors	author	NOUN
dpc-4148	173	9	found	find	VERB
dpc-4148	173	10	a	a	DET
dpc-4148	173	11	lower	low	ADJ
dpc-4148	173	12	expression	expression	NOUN
dpc-4148	173	13	of	of	ADP
dpc-4148	173	14	tlr9	tlr9	NOUN
dpc-4148	173	15	in	in	ADP
dpc-4148	173	16	the	the	DET
dpc-4148	173	17	patient	patient	NOUN
dpc-4148	173	18	group	group	NOUN
dpc-4148	173	19	.	.	PUNCT
dpc-4148	174	1	in	in	ADP
dpc-4148	174	2	our	our	PRON
dpc-4148	174	3	study	study	NOUN
dpc-4148	174	4	,	,	PUNCT
dpc-4148	174	5	we	we	PRON
dpc-4148	174	6	could	could	AUX
dpc-4148	174	7	not	not	PART
dpc-4148	174	8	detect	detect	VERB
dpc-4148	174	9	any	any	DET
dpc-4148	174	10	upregulation	upregulation	NOUN
dpc-4148	174	11	of	of	ADP
dpc-4148	174	12	tlr7	tlr7	NOUN
dpc-4148	174	13	expression	expression	NOUN
dpc-4148	174	14	,	,	PUNCT
dpc-4148	174	15	while	while	SCONJ
dpc-4148	174	16	the	the	DET
dpc-4148	174	17	upregulation	upregulation	NOUN
dpc-4148	174	18	of	of	ADP
dpc-4148	174	19	tlr9	tlr9	NOUN
dpc-4148	174	20	was	be	AUX
dpc-4148	174	21	without	without	ADP
dpc-4148	174	22	any	any	DET
dpc-4148	174	23	statistical	statistical	ADJ
dpc-4148	174	24	significance	significance	NOUN
dpc-4148	174	25	.	.	PUNCT
dpc-4148	175	1	the	the	DET
dpc-4148	175	2	presence	presence	NOUN
dpc-4148	175	3	of	of	ADP
dpc-4148	175	4	damps	damp	NOUN
dpc-4148	175	5	or	or	CCONJ
dpc-4148	175	6	danger	danger	NOUN
dpc-4148	175	7	signals	signal	NOUN
dpc-4148	175	8	and	and	CCONJ
dpc-4148	175	9	inducing	induce	VERB
dpc-4148	175	10	tlrs	tlrs	NOUN
dpc-4148	175	11	in	in	ADP
dpc-4148	175	12	association	association	NOUN
dpc-4148	175	13	with	with	ADP
dpc-4148	175	14	fibrosis	fibrosis	NOUN
dpc-4148	175	15	has	have	AUX
dpc-4148	175	16	already	already	ADV
dpc-4148	175	17	been	be	AUX
dpc-4148	175	18	stimulation	stimulation	NOUN
dpc-4148	175	19	by	by	ADP
dpc-4148	175	20	tlr	tlr	PROPN
dpc-4148	175	21	.	.	PUNCT
dpc-4148	176	1	there	there	PRON
dpc-4148	176	2	have	have	AUX
dpc-4148	176	3	been	be	AUX
dpc-4148	176	4	several	several	ADJ
dpc-4148	176	5	studies	study	NOUN
dpc-4148	176	6	examining	examine	VERB
dpc-4148	176	7	tlrs	tlrs	NOUN
dpc-4148	176	8	in	in	ADP
dpc-4148	176	9	systemic	systemic	ADJ
dpc-4148	176	10	sclerosis	sclerosis	NOUN
dpc-4148	177	1	[	[	X
dpc-4148	177	2	3,4,7,9,15,16	3,4,7,9,15,16	NUM
dpc-4148	177	3	,	,	PUNCT
dpc-4148	177	4	22	22	NUM
dpc-4148	177	5	-	-	SYM
dpc-4148	177	6	38	38	NUM
dpc-4148	177	7	]	]	PUNCT
dpc-4148	177	8	,	,	PUNCT
dpc-4148	177	9	but	but	CCONJ
dpc-4148	177	10	in	in	ADP
dpc-4148	177	11	localized	localized	ADJ
dpc-4148	177	12	scleroderma	scleroderma	NOUN
dpc-4148	177	13	this	this	DET
dpc-4148	177	14	issue	issue	NOUN
dpc-4148	177	15	is	be	AUX
dpc-4148	177	16	poorly	poorly	ADV
dpc-4148	177	17	understood	understand	VERB
dpc-4148	177	18	[	[	X
dpc-4148	177	19	22	22	NUM
dpc-4148	177	20	]	]	PUNCT
dpc-4148	177	21	.	.	PUNCT
dpc-4148	178	1	this	this	PRON
dpc-4148	178	2	may	may	AUX
dpc-4148	178	3	be	be	AUX
dpc-4148	178	4	due	due	ADJ
dpc-4148	178	5	to	to	ADP
dpc-4148	178	6	the	the	DET
dpc-4148	178	7	fact	fact	NOUN
dpc-4148	178	8	that	that	SCONJ
dpc-4148	178	9	although	although	SCONJ
dpc-4148	178	10	morphea	morphea	PROPN
dpc-4148	178	11	and	and	CCONJ
dpc-4148	178	12	systemic	systemic	ADJ
dpc-4148	178	13	scleroderma	scleroderma	NOUN
dpc-4148	178	14	have	have	VERB
dpc-4148	178	15	different	different	ADJ
dpc-4148	178	16	clinics	clinic	NOUN
dpc-4148	178	17	,	,	PUNCT
dpc-4148	178	18	they	they	PRON
dpc-4148	178	19	share	share	VERB
dpc-4148	178	20	a	a	DET
dpc-4148	178	21	common	common	ADJ
dpc-4148	178	22	pathological	pathological	ADJ
dpc-4148	178	23	and	and	CCONJ
dpc-4148	178	24	pathogenetic	pathogenetic	ADJ
dpc-4148	178	25	mechanism	mechanism	NOUN
dpc-4148	178	26	[	[	X
dpc-4148	178	27	15	15	NUM
dpc-4148	178	28	]	]	PUNCT
dpc-4148	178	29	.	.	PUNCT
dpc-4148	179	1	the	the	DET
dpc-4148	179	2	study	study	NOUN
dpc-4148	179	3	by	by	ADP
dpc-4148	179	4	agarwal	agarwal	PROPN
dpc-4148	179	5	and	and	CCONJ
dpc-4148	179	6	et	et	PROPN
dpc-4148	179	7	al	al	PROPN
dpc-4148	179	8	.	.	PROPN
dpc-4148	179	9	demonstrated	demonstrate	VERB
dpc-4148	179	10	that	that	SCONJ
dpc-4148	179	11	interferon	interferon	NOUN
dpc-4148	179	12	(	(	PUNCT
dpc-4148	179	13	ifn)-α2	ifn)-α2	PROPN
dpc-4148	179	14	upregulates	upregulate	VERB
dpc-4148	179	15	tlr3	tlr3	NOUN
dpc-4148	179	16	and	and	CCONJ
dpc-4148	179	17	increases	increase	VERB
dpc-4148	179	18	tlr3	tlr3	NOUN
dpc-4148	179	19	-	-	PUNCT
dpc-4148	179	20	induced	induce	VERB
dpc-4148	179	21	il-6	il-6	NUM
dpc-4148	179	22	production	production	NOUN
dpc-4148	179	23	,	,	PUNCT
dpc-4148	179	24	and	and	CCONJ
dpc-4148	179	25	this	this	DET
dpc-4148	179	26	activation	activation	NOUN
dpc-4148	179	27	of	of	ADP
dpc-4148	179	28	tlr3	tlr3	NOUN
dpc-4148	179	29	may	may	AUX
dpc-4148	179	30	cause	cause	VERB
dpc-4148	179	31	excessive	excessive	ADJ
dpc-4148	179	32	fibroblast	fibroblast	ADJ
dpc-4148	179	33	activation	activation	NOUN
dpc-4148	179	34	and	and	CCONJ
dpc-4148	179	35	collagen	collagen	NOUN
dpc-4148	179	36	production	production	NOUN
dpc-4148	179	37	in	in	ADP
dpc-4148	179	38	systemic	systemic	ADJ
dpc-4148	179	39	sclerosis	sclerosis	NOUN
dpc-4148	179	40	[	[	X
dpc-4148	179	41	23	23	NUM
dpc-4148	179	42	]	]	PUNCT
dpc-4148	179	43	.	.	PUNCT
dpc-4148	180	1	in	in	ADP
dpc-4148	180	2	our	our	PRON
dpc-4148	180	3	study	study	NOUN
dpc-4148	180	4	,	,	PUNCT
dpc-4148	180	5	we	we	PRON
dpc-4148	180	6	found	find	VERB
dpc-4148	180	7	an	an	DET
dpc-4148	180	8	increase	increase	NOUN
dpc-4148	180	9	in	in	ADP
dpc-4148	180	10	tlr3	tlr3	NOUN
dpc-4148	180	11	gene	gene	NOUN
dpc-4148	180	12	expressions	expression	NOUN
dpc-4148	180	13	in	in	ADP
dpc-4148	180	14	lesional	lesional	ADJ
dpc-4148	180	15	skin	skin	NOUN
dpc-4148	180	16	;	;	PUNCT
dpc-4148	180	17	however	however	ADV
dpc-4148	180	18	,	,	PUNCT
dpc-4148	180	19	this	this	DET
dpc-4148	180	20	difference	difference	NOUN
dpc-4148	180	21	was	be	AUX
dpc-4148	180	22	not	not	PART
dpc-4148	180	23	significant	significant	ADJ
dpc-4148	180	24	.	.	PUNCT
dpc-4148	181	1	this	this	DET
dpc-4148	181	2	result	result	NOUN
dpc-4148	181	3	could	could	AUX
dpc-4148	181	4	be	be	AUX
dpc-4148	181	5	related	relate	VERB
dpc-4148	181	6	to	to	ADP
dpc-4148	181	7	the	the	DET
dpc-4148	181	8	different	different	ADJ
dpc-4148	181	9	study	study	NOUN
dpc-4148	181	10	designs	design	NOUN
dpc-4148	181	11	(	(	PUNCT
dpc-4148	181	12	in	in	ADP
dpc-4148	181	13	vitro	vitro	NOUN
dpc-4148	181	14	/	/	SYM
dpc-4148	181	15	in	in	ADP
dpc-4148	181	16	vivo	vivo	NOUN
dpc-4148	181	17	)	)	PUNCT
dpc-4148	181	18	and	and	CCONJ
dpc-4148	181	19	the	the	DET
dpc-4148	181	20	number	number	NOUN
dpc-4148	181	21	of	of	ADP
dpc-4148	181	22	samples	sample	NOUN
dpc-4148	181	23	(	(	PUNCT
dpc-4148	181	24	four	four	NUM
dpc-4148	181	25	samples	sample	NOUN
dpc-4148	181	26	versus	versus	ADP
dpc-4148	181	27	15	15	NUM
dpc-4148	181	28	samples	sample	NOUN
dpc-4148	181	29	)	)	PUNCT
dpc-4148	181	30	.	.	PUNCT
dpc-4148	182	1	many	many	ADJ
dpc-4148	182	2	studies	study	NOUN
dpc-4148	182	3	have	have	AUX
dpc-4148	182	4	shown	show	VERB
dpc-4148	182	5	that	that	SCONJ
dpc-4148	182	6	tnfaip3	tnfaip3	NOUN
dpc-4148	182	7	–	–	PUNCT
dpc-4148	182	8	a	a	DET
dpc-4148	182	9	negative	negative	ADJ
dpc-4148	182	10	regulator	regulator	NOUN
dpc-4148	182	11	of	of	ADP
dpc-4148	182	12	tlr	tlr	PROPN
dpc-4148	182	13	signaling	signal	VERB
dpc-4148	182	14	–	–	PUNCT
dpc-4148	182	15	and	and	CCONJ
dpc-4148	182	16	tnfaip3	tnfaip3	NOUN
dpc-4148	182	17	-	-	PUNCT
dpc-4148	182	18	interacting	interact	VERB
dpc-4148	182	19	protein	protein	NOUN
dpc-4148	182	20	1	1	NUM
dpc-4148	182	21	(	(	PUNCT
dpc-4148	182	22	tnip1	tnip1	NOUN
dpc-4148	182	23	)	)	PUNCT
dpc-4148	182	24	are	be	AUX
dpc-4148	182	25	both	both	PRON
dpc-4148	182	26	strongly	strongly	ADV
dpc-4148	182	27	associated	associate	VERB
dpc-4148	182	28	with	with	ADP
dpc-4148	182	29	systemic	systemic	ADJ
dpc-4148	182	30	sclerosis	sclerosis	NOUN
dpc-4148	182	31	[	[	X
dpc-4148	182	32	24,25	24,25	NUM
dpc-4148	182	33	]	]	PUNCT
dpc-4148	182	34	.	.	PUNCT
dpc-4148	183	1	in	in	ADP
dpc-4148	183	2	addition	addition	NOUN
dpc-4148	183	3	,	,	PUNCT
dpc-4148	183	4	mrna	mrna	PROPN
dpc-4148	183	5	and	and	CCONJ
dpc-4148	183	6	protein	protein	NOUN
dpc-4148	183	7	levels	level	NOUN
dpc-4148	183	8	of	of	ADP
dpc-4148	183	9	tnip1	tnip1	NOUN
dpc-4148	183	10	were	be	AUX
dpc-4148	183	11	significantly	significantly	ADV
dpc-4148	183	12	reduced	reduce	VERB
dpc-4148	183	13	in	in	ADP
dpc-4148	183	14	lesional	lesional	ADJ
dpc-4148	183	15	skin	skin	NOUN
dpc-4148	183	16	and	and	CCONJ
dpc-4148	183	17	fibroblasts	fibroblast	NOUN
dpc-4148	183	18	of	of	ADP
dpc-4148	183	19	patients	patient	NOUN
dpc-4148	183	20	with	with	ADP
dpc-4148	183	21	systemic	systemic	ADJ
dpc-4148	183	22	sclerosis	sclerosis	NOUN
dpc-4148	183	23	[	[	X
dpc-4148	183	24	26	26	NUM
dpc-4148	183	25	]	]	PUNCT
dpc-4148	183	26	.	.	PUNCT
dpc-4148	184	1	some	some	DET
dpc-4148	184	2	studies	study	NOUN
dpc-4148	184	3	have	have	AUX
dpc-4148	184	4	shown	show	VERB
dpc-4148	184	5	increased	increased	ADJ
dpc-4148	184	6	expression	expression	NOUN
dpc-4148	184	7	of	of	ADP
dpc-4148	184	8	tlr3	tlr3	NOUN
dpc-4148	184	9	in	in	ADP
dpc-4148	184	10	skin	skin	NOUN
dpc-4148	184	11	biopsies	biopsy	NOUN
dpc-4148	184	12	from	from	ADP
dpc-4148	184	13	patients	patient	NOUN
dpc-4148	184	14	with	with	ADP
dpc-4148	184	15	systemic	systemic	ADJ
dpc-4148	184	16	sclerosis	sclerosis	NOUN
dpc-4148	184	17	[	[	X
dpc-4148	184	18	21,27	21,27	NUM
dpc-4148	184	19	]	]	PUNCT
dpc-4148	184	20	.	.	PUNCT
dpc-4148	185	1	they	they	PRON
dpc-4148	185	2	also	also	ADV
dpc-4148	185	3	showed	show	VERB
dpc-4148	185	4	that	that	SCONJ
dpc-4148	185	5	in	in	ADP
dpc-4148	185	6	normal	normal	ADJ
dpc-4148	185	7	skin	skin	NOUN
dpc-4148	185	8	fibroblasts	fibroblast	NOUN
dpc-4148	185	9	,	,	PUNCT
dpc-4148	185	10	tlr3	tlr3	PROPN
dpc-4148	185	11	stimulation	stimulation	VERB
dpc-4148	185	12	increased	increase	VERB
dpc-4148	185	13	ifn	ifn	PROPN
dpc-4148	185	14	-	-	PUNCT
dpc-4148	185	15	β	β	NOUN
dpc-4148	185	16	production	production	NOUN
dpc-4148	185	17	and	and	CCONJ
dpc-4148	185	18	the	the	DET
dpc-4148	185	19	expression	expression	NOUN
dpc-4148	185	20	of	of	ADP
dpc-4148	185	21	ifn	ifn	NOUN
dpc-4148	185	22	-	-	PUNCT
dpc-4148	185	23	regulated	regulate	VERB
dpc-4148	185	24	genes	gene	NOUN
dpc-4148	185	25	[	[	X
dpc-4148	185	26	27	27	NUM
dpc-4148	185	27	]	]	PUNCT
dpc-4148	185	28	.	.	PUNCT
dpc-4148	186	1	in	in	ADP
dpc-4148	186	2	addition	addition	NOUN
dpc-4148	186	3	,	,	PUNCT
dpc-4148	186	4	the	the	DET
dpc-4148	186	5	expression	expression	NOUN
dpc-4148	186	6	of	of	ADP
dpc-4148	186	7	fibrotic	fibrotic	ADJ
dpc-4148	186	8	genes	gene	NOUN
dpc-4148	186	9	was	be	AUX
dpc-4148	186	10	inhibited	inhibit	VERB
dpc-4148	186	11	.	.	PUNCT
dpc-4148	187	1	similarly	similarly	ADV
dpc-4148	187	2	,	,	PUNCT
dpc-4148	187	3	injection	injection	NOUN
dpc-4148	187	4	of	of	ADP
dpc-4148	187	5	a	a	DET
dpc-4148	187	6	tlr3	tlr3	PROPN
dpc-4148	187	7	ligand	ligand	NOUN
dpc-4148	187	8	was	be	AUX
dpc-4148	187	9	found	find	VERB
dpc-4148	187	10	to	to	PART
dpc-4148	187	11	induce	induce	VERB
dpc-4148	187	12	dermal	dermal	ADJ
dpc-4148	187	13	inflammation	inflammation	NOUN
dpc-4148	187	14	and	and	CCONJ
dpc-4148	187	15	the	the	DET
dpc-4148	187	16	expression	expression	NOUN
dpc-4148	187	17	of	of	ADP
dpc-4148	187	18	ifn	ifn	NOUN
dpc-4148	187	19	-	-	PUNCT
dpc-4148	187	20	regulated	regulate	VERB
dpc-4148	187	21	and	and	CCONJ
dpc-4148	187	22	fibrotic	fibrotic	ADJ
dpc-4148	187	23	genes	gene	NOUN
dpc-4148	187	24	in	in	ADP
dpc-4148	187	25	experimental	experimental	ADJ
dpc-4148	187	26	mice	mouse	NOUN
dpc-4148	187	27	[	[	X
dpc-4148	187	28	28	28	NUM
dpc-4148	187	29	]	]	PUNCT
dpc-4148	187	30	.	.	PUNCT
dpc-4148	188	1	in	in	ADP
dpc-4148	188	2	our	our	PRON
dpc-4148	188	3	study	study	NOUN
dpc-4148	188	4	,	,	PUNCT
dpc-4148	188	5	we	we	PRON
dpc-4148	188	6	also	also	ADV
dpc-4148	188	7	found	find	VERB
dpc-4148	188	8	higher	high	ADJ
dpc-4148	188	9	expression	expression	NOUN
dpc-4148	188	10	of	of	ADP
dpc-4148	188	11	tlr3	tlr3	NOUN
dpc-4148	188	12	in	in	ADP
dpc-4148	188	13	the	the	DET
dpc-4148	188	14	patient	patient	NOUN
dpc-4148	188	15	group	group	NOUN
dpc-4148	188	16	,	,	PUNCT
dpc-4148	188	17	with	with	ADP
dpc-4148	188	18	no	no	DET
dpc-4148	188	19	significant	significant	ADJ
dpc-4148	188	20	difference	difference	NOUN
dpc-4148	188	21	.	.	PUNCT
dpc-4148	189	1	this	this	DET
dpc-4148	189	2	difference	difference	NOUN
dpc-4148	189	3	could	could	AUX
dpc-4148	189	4	again	again	ADV
dpc-4148	189	5	be	be	AUX
dpc-4148	189	6	related	relate	VERB
dpc-4148	189	7	to	to	ADP
dpc-4148	189	8	the	the	DET
dpc-4148	189	9	different	different	ADJ
dpc-4148	189	10	study	study	NOUN
dpc-4148	189	11	designs	design	NOUN
dpc-4148	189	12	(	(	PUNCT
dpc-4148	189	13	in	in	ADP
dpc-4148	189	14	vitro	vitro	NOUN
dpc-4148	189	15	/	/	SYM
dpc-4148	189	16	in	in	ADP
dpc-4148	189	17	vivo	vivo	NOUN
dpc-4148	189	18	)	)	PUNCT
dpc-4148	189	19	.	.	PUNCT
dpc-4148	190	1	bhattacharyya	bhattacharyya	ADJ
dpc-4148	190	2	and	and	CCONJ
dpc-4148	190	3	et	et	PROPN
dpc-4148	190	4	al	al	PROPN
dpc-4148	190	5	.	.	PROPN
dpc-4148	190	6	showed	show	VERB
dpc-4148	190	7	that	that	SCONJ
dpc-4148	190	8	the	the	DET
dpc-4148	190	9	expression	expression	NOUN
dpc-4148	190	10	of	of	ADP
dpc-4148	190	11	tlr4	tlr4	NOUN
dpc-4148	190	12	was	be	AUX
dpc-4148	190	13	greatly	greatly	ADV
dpc-4148	190	14	increased	increase	VERB
dpc-4148	190	15	in	in	ADP
dpc-4148	190	16	fibroblasts	fibroblast	NOUN
dpc-4148	190	17	and	and	CCONJ
dpc-4148	190	18	vascular	vascular	ADJ
dpc-4148	190	19	cells	cell	NOUN
dpc-4148	190	20	of	of	ADP
dpc-4148	190	21	skin	skin	NOUN
dpc-4148	190	22	biopsies	biopsy	NOUN
dpc-4148	190	23	from	from	ADP
dpc-4148	190	24	patients	patient	NOUN
dpc-4148	190	25	with	with	ADP
dpc-4148	190	26	systemic	systemic	ADJ
dpc-4148	190	27	sclerosis	sclerosis	NOUN
dpc-4148	190	28	[	[	X
dpc-4148	190	29	11	11	NUM
dpc-4148	190	30	]	]	PUNCT
dpc-4148	190	31	.	.	PUNCT
dpc-4148	191	1	another	another	DET
dpc-4148	191	2	report	report	NOUN
dpc-4148	191	3	by	by	ADP
dpc-4148	191	4	stifano	stifano	PROPN
dpc-4148	191	5	showed	show	VERB
dpc-4148	191	6	that	that	SCONJ
dpc-4148	191	7	both	both	DET
dpc-4148	191	8	tlr4	tlr4	NOUN
dpc-4148	191	9	and	and	CCONJ
dpc-4148	191	10	its	its	PRON
dpc-4148	191	11	co	co	NOUN
dpc-4148	191	12	-	-	NOUN
dpc-4148	191	13	receptors	receptor	NOUN
dpc-4148	191	14	–	–	PUNCT
dpc-4148	191	15	md2	md2	PROPN
dpc-4148	191	16	and	and	CCONJ
dpc-4148	191	17	cd14	cd14	PROPN
dpc-4148	191	18	–	–	PUNCT
dpc-4148	191	19	were	be	AUX
dpc-4148	191	20	increased	increase	VERB
dpc-4148	191	21	in	in	ADP
dpc-4148	191	22	lesional	lesional	ADJ
dpc-4148	191	23	skin	skin	NOUN
dpc-4148	191	24	[	[	X
dpc-4148	191	25	12	12	NUM
dpc-4148	191	26	]	]	PUNCT
dpc-4148	191	27	.	.	PUNCT
dpc-4148	192	1	it	it	PRON
dpc-4148	192	2	was	be	AUX
dpc-4148	192	3	also	also	ADV
dpc-4148	192	4	found	find	VERB
dpc-4148	192	5	that	that	SCONJ
dpc-4148	192	6	tlr4	tlr4	NOUN
dpc-4148	192	7	levels	level	NOUN
dpc-4148	192	8	correlated	correlate	VERB
dpc-4148	192	9	with	with	ADP
dpc-4148	192	10	skin	skin	NOUN
dpc-4148	192	11	disease	disease	NOUN
dpc-4148	192	12	progression	progression	NOUN
dpc-4148	192	13	.	.	PUNCT
dpc-4148	193	1	in	in	ADP
dpc-4148	193	2	another	another	DET
dpc-4148	193	3	study	study	NOUN
dpc-4148	193	4	by	by	ADP
dpc-4148	193	5	the	the	DET
dpc-4148	193	6	same	same	ADJ
dpc-4148	193	7	group	group	NOUN
dpc-4148	193	8	of	of	ADP
dpc-4148	193	9	authors	author	NOUN
dpc-4148	193	10	,	,	PUNCT
dpc-4148	193	11	tenascin	tenascin	VERB
dpc-4148	193	12	c	c	NOUN
dpc-4148	193	13	–	–	PUNCT
dpc-4148	193	14	another	another	DET
dpc-4148	193	15	endogenous	endogenous	ADJ
dpc-4148	193	16	ligand	ligand	NOUN
dpc-4148	193	17	for	for	ADP
dpc-4148	193	18	tlr-4	tlr-4	PRON
dpc-4148	193	19	and	and	CCONJ
dpc-4148	193	20	profibrotic	profibrotic	ADJ
dpc-4148	193	21	molecule	molecule	NOUN
dpc-4148	193	22	–	–	PUNCT
dpc-4148	193	23	was	be	AUX
dpc-4148	193	24	investigated	investigate	VERB
dpc-4148	193	25	in	in	ADP
dpc-4148	193	26	systemic	systemic	ADJ
dpc-4148	193	27	sclerosis	sclerosis	NOUN
dpc-4148	193	28	.	.	PUNCT
dpc-4148	194	1	tenascin	tenascin	PROPN
dpc-4148	194	2	c	c	PROPN
dpc-4148	194	3	plays	play	VERB
dpc-4148	194	4	a	a	DET
dpc-4148	194	5	role	role	NOUN
dpc-4148	194	6	in	in	ADP
dpc-4148	194	7	wound	wound	ADJ
dpc-4148	194	8	healing	healing	NOUN
dpc-4148	194	9	and	and	CCONJ
dpc-4148	194	10	tissue	tissue	NOUN
dpc-4148	194	11	remodeling	remodeling	NOUN
dpc-4148	194	12	.	.	PUNCT
dpc-4148	195	1	the	the	DET
dpc-4148	195	2	authors	author	NOUN
dpc-4148	195	3	demonstrated	demonstrate	VERB
dpc-4148	195	4	that	that	SCONJ
dpc-4148	195	5	tenascin	tenascin	VERB
dpc-4148	195	6	c	c	PROPN
dpc-4148	195	7	levels	level	NOUN
dpc-4148	195	8	were	be	AUX
dpc-4148	195	9	increased	increase	VERB
dpc-4148	195	10	in	in	ADP
dpc-4148	195	11	the	the	DET
dpc-4148	195	12	skin	skin	NOUN
dpc-4148	195	13	,	,	PUNCT
dpc-4148	195	14	serum	serum	NOUN
dpc-4148	195	15	,	,	PUNCT
dpc-4148	195	16	and	and	CCONJ
dpc-4148	195	17	sclerotic	sclerotic	ADJ
dpc-4148	195	18	fibroblasts	fibroblast	NOUN
dpc-4148	195	19	of	of	ADP
dpc-4148	195	20	patients	patient	NOUN
dpc-4148	195	21	with	with	ADP
dpc-4148	195	22	systemic	systemic	ADJ
dpc-4148	195	23	sclerosis	sclerosis	NOUN
dpc-4148	195	24	and	and	CCONJ
dpc-4148	195	25	in	in	ADP
dpc-4148	195	26	fibrotic	fibrotic	ADJ
dpc-4148	195	27	skin	skin	NOUN
dpc-4148	195	28	tissue	tissue	NOUN
dpc-4148	195	29	of	of	ADP
dpc-4148	195	30	mice	mouse	NOUN
dpc-4148	195	31	.	.	PUNCT
dpc-4148	196	1	furthermore	furthermore	ADV
dpc-4148	196	2	,	,	PUNCT
dpc-4148	196	3	exogenous	exogenous	ADJ
dpc-4148	196	4	tenascin	tenascin	NOUN
dpc-4148	196	5	-	-	PUNCT
dpc-4148	196	6	c	c	NOUN
dpc-4148	196	7	leads	lead	VERB
dpc-4148	196	8	to	to	ADP
dpc-4148	196	9	stimulation	stimulation	NOUN
dpc-4148	196	10	of	of	ADP
dpc-4148	196	11	collagen	collagen	NOUN
dpc-4148	196	12	gene	gene	NOUN
dpc-4148	196	13	expression	expression	NOUN
dpc-4148	196	14	and	and	CCONJ
dpc-4148	196	15	transformation	transformation	NOUN
dpc-4148	196	16	of	of	ADP
dpc-4148	196	17	myofibroblasts	myofibroblast	NOUN
dpc-4148	196	18	via	via	ADP
dpc-4148	196	19	tlr4	tlr4	NOUN
dpc-4148	196	20	signaling	signal	VERB
dpc-4148	196	21	[	[	X
dpc-4148	196	22	29	29	NUM
dpc-4148	196	23	]	]	PUNCT
dpc-4148	196	24	.	.	PUNCT
dpc-4148	197	1	in	in	ADP
dpc-4148	197	2	our	our	PRON
dpc-4148	197	3	results	result	NOUN
dpc-4148	197	4	,	,	PUNCT
dpc-4148	197	5	we	we	PRON
dpc-4148	197	6	could	could	AUX
dpc-4148	197	7	not	not	PART
dpc-4148	197	8	detect	detect	VERB
dpc-4148	197	9	an	an	DET
dpc-4148	197	10	increase	increase	NOUN
dpc-4148	197	11	in	in	ADP
dpc-4148	197	12	the	the	DET
dpc-4148	197	13	expression	expression	NOUN
dpc-4148	197	14	of	of	ADP
dpc-4148	197	15	tlr4	tlr4	NOUN
dpc-4148	197	16	.	.	PUNCT
dpc-4148	198	1	this	this	DET
dpc-4148	198	2	difference	difference	NOUN
dpc-4148	198	3	could	could	AUX
dpc-4148	198	4	be	be	AUX
dpc-4148	198	5	related	relate	VERB
dpc-4148	198	6	to	to	ADP
dpc-4148	198	7	the	the	DET
dpc-4148	198	8	type	type	NOUN
dpc-4148	198	9	of	of	ADP
dpc-4148	198	10	disease	disease	NOUN
dpc-4148	198	11	(	(	PUNCT
dpc-4148	198	12	localized/	localized/	NUM
dpc-4148	198	13	8	8	NUM
dpc-4148	198	14	original	original	ADJ
dpc-4148	198	15	article	article	NOUN
dpc-4148	198	16	|	|	ADV
dpc-4148	198	17	dermatol	dermatol	ADJ
dpc-4148	198	18	pract	pract	NOUN
dpc-4148	198	19	concept	concept	NOUN
dpc-4148	198	20	.	.	PUNCT
dpc-4148	199	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	199	2	in	in	ADP
dpc-4148	199	3	synovial	synovial	ADJ
dpc-4148	199	4	fibroblasts	fibroblast	NOUN
dpc-4148	199	5	.	.	PUNCT
dpc-4148	200	1	rheumatology	rheumatology	NOUN
dpc-4148	200	2	.	.	PUNCT
dpc-4148	201	1	2011;50:1216	2011;50:1216	NUM
dpc-4148	201	2	-	-	SYM
dpc-4148	201	3	1225	1225	NUM
dpc-4148	201	4	.	.	PUNCT
dpc-4148	202	1	doi	doi	NOUN
dpc-4148	202	2	:	:	PUNCT
dpc-4148	202	3	10.1093	10.1093	NUM
dpc-4148	202	4	/	/	SYM
dpc-4148	202	5	rheumatology	rheumatology	NOUN
dpc-4148	202	6	/	/	SYM
dpc-4148	202	7	ker021	ker021	PROPN
dpc-4148	202	8	.	.	PROPN
dpc-4148	203	1	10	10	NUM
dpc-4148	203	2	.	.	PUNCT
dpc-4148	204	1	christensen	christensen	PROPN
dpc-4148	204	2	sr	sr	PROPN
dpc-4148	204	3	,	,	PUNCT
dpc-4148	204	4	shupe	shupe	PROPN
dpc-4148	204	5	j	j	PROPN
dpc-4148	204	6	,	,	PUNCT
dpc-4148	204	7	nickerson	nickerson	PROPN
dpc-4148	204	8	k	k	PROPN
dpc-4148	204	9	,	,	PUNCT
dpc-4148	204	10	kashgarian	kashgarian	PROPN
dpc-4148	204	11	m	m	PROPN
dpc-4148	204	12	,	,	PUNCT
dpc-4148	204	13	flavell	flavell	PROPN
dpc-4148	204	14	ra	ra	PROPN
dpc-4148	204	15	,	,	PUNCT
dpc-4148	204	16	shlomchik	shlomchik	PROPN
dpc-4148	204	17	mj	mj	PROPN
dpc-4148	204	18	.	.	PUNCT
dpc-4148	204	19	toll	toll	NOUN
dpc-4148	204	20	-	-	PUNCT
dpc-4148	204	21	like	like	ADJ
dpc-4148	204	22	receptor	receptor	NOUN
dpc-4148	204	23	7	7	NUM
dpc-4148	204	24	and	and	CCONJ
dpc-4148	204	25	tlr9	tlr9	NOUN
dpc-4148	204	26	dictate	dictate	VERB
dpc-4148	204	27	autoantibody	autoantibody	ADJ
dpc-4148	204	28	specificity	specificity	NOUN
dpc-4148	204	29	and	and	CCONJ
dpc-4148	204	30	have	have	AUX
dpc-4148	204	31	opposing	oppose	VERB
dpc-4148	204	32	inflammatory	inflammatory	ADJ
dpc-4148	204	33	and	and	CCONJ
dpc-4148	204	34	regulatory	regulatory	ADJ
dpc-4148	204	35	roles	role	NOUN
dpc-4148	204	36	in	in	ADP
dpc-4148	204	37	a	a	DET
dpc-4148	204	38	murine	murine	ADJ
dpc-4148	204	39	model	model	NOUN
dpc-4148	204	40	of	of	ADP
dpc-4148	204	41	lupus	lupus	NOUN
dpc-4148	204	42	.	.	PUNCT
dpc-4148	205	1	immunity.2006	immunity.2006	NOUN
dpc-4148	205	2	;	;	PUNCT
dpc-4148	205	3	25:417–428	25:417–428	PROPN
dpc-4148	205	4	.	.	PUNCT
dpc-4148	206	1	doi	doi	NOUN
dpc-4148	206	2	:	:	PUNCT
dpc-4148	206	3	10.1016	10.1016	NUM
dpc-4148	206	4	/	/	SYM
dpc-4148	206	5	j.immuni.2006.07.013	j.immuni.2006.07.013	PROPN
dpc-4148	206	6	.	.	PROPN
dpc-4148	206	7	11	11	NUM
dpc-4148	206	8	.	.	PUNCT
dpc-4148	207	1	bhattacharyya	bhattacharyya	PROPN
dpc-4148	207	2	s	s	PROPN
dpc-4148	207	3	,	,	PUNCT
dpc-4148	207	4	kelley	kelley	PROPN
dpc-4148	207	5	k	k	PROPN
dpc-4148	207	6	,	,	PUNCT
dpc-4148	207	7	melichian	melichian	PROPN
dpc-4148	207	8	ds	ds	PROPN
dpc-4148	207	9	,	,	PUNCT
dpc-4148	207	10	et	et	PROPN
dpc-4148	207	11	al	al	PROPN
dpc-4148	207	12	.	.	PUNCT
dpc-4148	208	1	toll	toll	NOUN
dpc-4148	208	2	-	-	PUNCT
dpc-4148	208	3	like	like	ADJ
dpc-4148	208	4	receptor	receptor	NOUN
dpc-4148	208	5	4	4	NUM
dpc-4148	208	6	signaling	signal	VERB
dpc-4148	208	7	augments	augment	NOUN
dpc-4148	208	8	transforming	transform	VERB
dpc-4148	208	9	growth	growth	NOUN
dpc-4148	208	10	factor	factor	NOUN
dpc-4148	208	11	-	-	PUNCT
dpc-4148	208	12	beta	beta	NOUN
dpc-4148	208	13	responses	response	NOUN
dpc-4148	208	14	:	:	PUNCT
dpc-4148	208	15	a	a	DET
dpc-4148	208	16	novel	novel	ADJ
dpc-4148	208	17	mechanism	mechanism	NOUN
dpc-4148	208	18	for	for	ADP
dpc-4148	208	19	maintaining	maintain	VERB
dpc-4148	208	20	and	and	CCONJ
dpc-4148	208	21	amplifying	amplifying	ADJ
dpc-4148	208	22	fibrosis	fibrosis	NOUN
dpc-4148	208	23	in	in	ADP
dpc-4148	208	24	scleroderma	scleroderma	NOUN
dpc-4148	208	25	.	.	PUNCT
dpc-4148	209	1	am	be	AUX
dpc-4148	209	2	j	j	PROPN
dpc-4148	209	3	pathol	pathol	NOUN
dpc-4148	209	4	.	.	PUNCT
dpc-4148	210	1	2013;182(1	2013;182(1	NUM
dpc-4148	210	2	):	):	PUNCT
dpc-4148	210	3	192–205	192–205	NUM
dpc-4148	210	4	.	.	PUNCT
dpc-4148	211	1	doi	doi	NOUN
dpc-4148	211	2	:	:	PUNCT
dpc-4148	211	3	10.1016	10.1016	NUM
dpc-4148	211	4	/	/	SYM
dpc-4148	211	5	j.ajpath.2012.09.007	j.ajpath.2012.09.007	PROPN
dpc-4148	211	6	.	.	PROPN
dpc-4148	212	1	12	12	NUM
dpc-4148	212	2	.	.	PUNCT
dpc-4148	213	1	stifano	stifano	PROPN
dpc-4148	213	2	g	g	PROPN
dpc-4148	213	3	,	,	PUNCT
dpc-4148	213	4	affandi	affandi	PROPN
dpc-4148	213	5	aj	aj	PROPN
dpc-4148	213	6	,	,	PUNCT
dpc-4148	213	7	mathes	mathes	PROPN
dpc-4148	213	8	al	al	PROPN
dpc-4148	213	9	,	,	PUNCT
dpc-4148	213	10	et	et	PROPN
dpc-4148	213	11	al	al	PROPN
dpc-4148	213	12	.	.	PROPN
dpc-4148	213	13	chronic	chronic	ADJ
dpc-4148	213	14	toll	toll	NOUN
dpc-4148	213	15	-	-	PUNCT
dpc-4148	213	16	like	like	ADJ
dpc-4148	213	17	receptor	receptor	NOUN
dpc-4148	213	18	4	4	NUM
dpc-4148	213	19	stimulation	stimulation	NOUN
dpc-4148	213	20	in	in	ADP
dpc-4148	213	21	skin	skin	NOUN
dpc-4148	213	22	induces	induce	VERB
dpc-4148	213	23	inflammation	inflammation	NOUN
dpc-4148	213	24	,	,	PUNCT
dpc-4148	213	25	macrophage	macrophage	ADJ
dpc-4148	213	26	activation	activation	NOUN
dpc-4148	213	27	,	,	PUNCT
dpc-4148	213	28	transforming	transform	VERB
dpc-4148	213	29	growth	growth	NOUN
dpc-4148	213	30	factor	factor	NOUN
dpc-4148	213	31	beta	beta	NOUN
dpc-4148	213	32	signature	signature	NOUN
dpc-4148	213	33	gene	gene	NOUN
dpc-4148	213	34	expression	expression	NOUN
dpc-4148	213	35	,	,	PUNCT
dpc-4148	213	36	and	and	CCONJ
dpc-4148	213	37	fibrosis	fibrosis	NOUN
dpc-4148	213	38	.	.	PUNCT
dpc-4148	214	1	arthritis	arthritis	NOUN
dpc-4148	214	2	res	re	NOUN
dpc-4148	214	3	ther	ther	ADV
dpc-4148	214	4	.	.	PUNCT
dpc-4148	215	1	2014;16(4):r136	2014;16(4):r136	NOUN
dpc-4148	215	2	.	.	PUNCT
dpc-4148	216	1	doi	doi	NOUN
dpc-4148	216	2	:	:	PUNCT
dpc-4148	216	3	10.1186	10.1186	NUM
dpc-4148	216	4	/	/	SYM
dpc-4148	216	5	ar4598	ar4598	ADJ
dpc-4148	216	6	.	.	PUNCT
dpc-4148	217	1	13	13	NUM
dpc-4148	217	2	.	.	PUNCT
dpc-4148	218	1	matucci	matucci	NOUN
dpc-4148	218	2	-	-	PUNCT
dpc-4148	218	3	cerinic	cerinic	ADJ
dpc-4148	218	4	m	m	PROPN
dpc-4148	218	5	,	,	PUNCT
dpc-4148	218	6	kahaleh	kahaleh	PROPN
dpc-4148	218	7	b	b	PROPN
dpc-4148	218	8	,	,	PUNCT
dpc-4148	218	9	wigley	wigley	PROPN
dpc-4148	218	10	fm	fm	PROPN
dpc-4148	218	11	.	.	PROPN
dpc-4148	218	12	review	review	NOUN
dpc-4148	218	13	:	:	PUNCT
dpc-4148	218	14	evidence	evidence	NOUN
dpc-4148	218	15	that	that	SCONJ
dpc-4148	218	16	systemic	systemic	ADJ
dpc-4148	218	17	sclerosis	sclerosis	NOUN
dpc-4148	218	18	is	be	AUX
dpc-4148	218	19	a	a	DET
dpc-4148	218	20	vascular	vascular	ADJ
dpc-4148	218	21	disease	disease	NOUN
dpc-4148	218	22	.	.	PUNCT
dpc-4148	219	1	arthritis	arthritis	NOUN
dpc-4148	219	2	rheum	rheum	NOUN
dpc-4148	219	3	.	.	PUNCT
dpc-4148	220	1	2013	2013	NUM
dpc-4148	220	2	;	;	PUNCT
dpc-4148	221	1	65(8):1953	65(8):1953	NUM
dpc-4148	221	2	-	-	SYM
dpc-4148	221	3	1962	1962	NUM
dpc-4148	221	4	.	.	PUNCT
dpc-4148	222	1	doi	doi	NOUN
dpc-4148	222	2	:	:	PUNCT
dpc-4148	222	3	10.1002	10.1002	NUM
dpc-4148	222	4	/	/	SYM
dpc-4148	222	5	art.37988	art.37988	NOUN
dpc-4148	222	6	.	.	NOUN
dpc-4148	222	7	14	14	NUM
dpc-4148	222	8	.	.	PUNCT
dpc-4148	223	1	distler	distler	NOUN
dpc-4148	223	2	o	o	PROPN
dpc-4148	223	3	,	,	PUNCT
dpc-4148	223	4	del	del	PROPN
dpc-4148	223	5	rosso	rosso	PROPN
dpc-4148	223	6	a	a	PROPN
dpc-4148	223	7	,	,	PUNCT
dpc-4148	223	8	giacomelli	giacomelli	PROPN
dpc-4148	223	9	ret	ret	PROPN
dpc-4148	223	10	al	al	PROPN
dpc-4148	223	11	.	.	PROPN
dpc-4148	223	12	angiogenic	angiogenic	PROPN
dpc-4148	223	13	and	and	CCONJ
dpc-4148	223	14	angiostatic	angiostatic	ADJ
dpc-4148	223	15	factors	factor	NOUN
dpc-4148	223	16	in	in	ADP
dpc-4148	223	17	systemic	systemic	ADJ
dpc-4148	223	18	sclerosis	sclerosis	NOUN
dpc-4148	223	19	:	:	PUNCT
dpc-4148	223	20	increased	increase	VERB
dpc-4148	223	21	levels	level	NOUN
dpc-4148	223	22	of	of	ADP
dpc-4148	223	23	vascular	vascular	ADJ
dpc-4148	223	24	endothelial	endothelial	ADJ
dpc-4148	223	25	growth	growth	NOUN
dpc-4148	223	26	factor	factor	NOUN
dpc-4148	223	27	are	be	AUX
dpc-4148	223	28	a	a	DET
dpc-4148	223	29	feature	feature	NOUN
dpc-4148	223	30	of	of	ADP
dpc-4148	223	31	the	the	DET
dpc-4148	223	32	earliest	early	ADJ
dpc-4148	223	33	disease	disease	NOUN
dpc-4148	223	34	stages	stage	NOUN
dpc-4148	223	35	and	and	CCONJ
dpc-4148	223	36	are	be	AUX
dpc-4148	223	37	associated	associate	VERB
dpc-4148	223	38	with	with	ADP
dpc-4148	223	39	the	the	DET
dpc-4148	223	40	absence	absence	NOUN
dpc-4148	223	41	of	of	ADP
dpc-4148	223	42	fingertip	fingertip	NOUN
dpc-4148	223	43	ulcers	ulcer	NOUN
dpc-4148	223	44	.	.	PUNCT
dpc-4148	224	1	arthritis	arthritis	NOUN
dpc-4148	224	2	res	re	NOUN
dpc-4148	224	3	.	.	PUNCT
dpc-4148	225	1	2002;4(6):r11	2002;4(6):r11	X
dpc-4148	225	2	.	.	PUNCT
dpc-4148	226	1	doi	doi	PROPN
dpc-4148	226	2	:	:	PUNCT
dpc-4148	226	3	10.1186	10.1186	NUM
dpc-4148	226	4	/	/	SYM
dpc-4148	226	5	ar596	ar596	NOUN
dpc-4148	226	6	.	.	PUNCT
dpc-4148	227	1	15	15	NUM
dpc-4148	227	2	.	.	PUNCT
dpc-4148	228	1	rongioletti	rongioletti	PROPN
dpc-4148	228	2	f	f	PROPN
dpc-4148	228	3	,	,	PUNCT
dpc-4148	228	4	ferreli	ferreli	VERB
dpc-4148	228	5	c	c	X
dpc-4148	228	6	,	,	PUNCT
dpc-4148	228	7	atzori	atzori	PROPN
dpc-4148	228	8	l	l	PROPN
dpc-4148	228	9	,	,	PUNCT
dpc-4148	228	10	bottoni	bottoni	PROPN
dpc-4148	228	11	u	u	NOUN
dpc-4148	228	12	,	,	PUNCT
dpc-4148	228	13	soda	soda	NOUN
dpc-4148	228	14	g.	g.	PROPN
dpc-4148	228	15	scleroderma	scleroderma	PROPN
dpc-4148	228	16	with	with	ADP
dpc-4148	228	17	an	an	DET
dpc-4148	228	18	update	update	NOUN
dpc-4148	228	19	about	about	ADP
dpc-4148	228	20	clinico	clinico	NOUN
dpc-4148	228	21	-	-	PUNCT
dpc-4148	228	22	pathological	pathological	ADJ
dpc-4148	228	23	correlation	correlation	NOUN
dpc-4148	228	24	.	.	PUNCT
dpc-4148	229	1	g	g	PROPN
dpc-4148	229	2	ital	ital	ADJ
dpc-4148	229	3	dermatol	dermatol	NOUN
dpc-4148	229	4	venereol	venereol	NOUN
dpc-4148	229	5	.	.	PUNCT
dpc-4148	230	1	2018;153(2):208	2018;153(2):208	NUM
dpc-4148	230	2	-	-	SYM
dpc-4148	230	3	215	215	NUM
dpc-4148	230	4	.	.	PUNCT
dpc-4148	230	5	doi	doi	NOUN
dpc-4148	230	6	:	:	PUNCT
dpc-4148	230	7	10.23736	10.23736	NUM
dpc-4148	230	8	/s0392	/s0392	NOUN
dpc-4148	230	9	-	-	PUNCT
dpc-4148	230	10	0488.18.05922	0488.18.05922	NUM
dpc-4148	230	11	-	-	PUNCT
dpc-4148	230	12	9	9	NUM
dpc-4148	230	13	.	.	NOUN
dpc-4148	230	14	16	16	NUM
dpc-4148	230	15	.	.	PUNCT
dpc-4148	231	1	kurzinski	kurzinski	PROPN
dpc-4148	231	2	k	k	NOUN
dpc-4148	231	3	,	,	PUNCT
dpc-4148	231	4	torok	torok	PROPN
dpc-4148	231	5	ks	ks	PROPN
dpc-4148	231	6	.	.	PROPN
dpc-4148	231	7	cytokine	cytokine	ADJ
dpc-4148	231	8	profiles	profile	NOUN
dpc-4148	231	9	in	in	ADP
dpc-4148	231	10	localized	localized	ADJ
dpc-4148	231	11	scleroderma	scleroderma	NOUN
dpc-4148	231	12	and	and	CCONJ
dpc-4148	231	13	relationship	relationship	NOUN
dpc-4148	231	14	to	to	ADP
dpc-4148	231	15	clinical	clinical	ADJ
dpc-4148	231	16	features	feature	NOUN
dpc-4148	231	17	.	.	PUNCT
dpc-4148	232	1	cytokine	cytokine	VERB
dpc-4148	232	2	.	.	PUNCT
dpc-4148	233	1	2011;55(2):157164	2011;55(2):157164	NOUN
dpc-4148	233	2	.	.	PUNCT
dpc-4148	233	3	doi:10.1016	doi:10.1016	PROPN
dpc-4148	233	4	/	/	SYM
dpc-4148	233	5	j.cyto.2011.04.001	j.cyto.2011.04.001	PROPN
dpc-4148	233	6	17	17	NUM
dpc-4148	233	7	.	.	PUNCT
dpc-4148	234	1	abbas	abbas	PROPN
dpc-4148	234	2	l	l	PROPN
dpc-4148	234	3	,	,	PUNCT
dpc-4148	234	4	joseph	joseph	PROPN
dpc-4148	234	5	a	a	PROPN
dpc-4148	234	6	,	,	PUNCT
dpc-4148	234	7	kunzler	kunzler	PROPN
dpc-4148	234	8	e	e	NOUN
dpc-4148	234	9	,	,	PUNCT
dpc-4148	234	10	jacobe	jacobe	PROPN
dpc-4148	234	11	ht	ht	PROPN
dpc-4148	234	12	.	.	PUNCT
dpc-4148	234	13	morphea	morphea	PROPN
dpc-4148	234	14	:	:	PUNCT
dpc-4148	234	15	progress	progress	NOUN
dpc-4148	234	16	to	to	ADP
dpc-4148	234	17	date	date	NOUN
dpc-4148	234	18	and	and	CCONJ
dpc-4148	234	19	the	the	DET
dpc-4148	234	20	road	road	NOUN
dpc-4148	234	21	ahead	ahead	ADV
dpc-4148	234	22	.	.	PUNCT
dpc-4148	235	1	ann	ann	PROPN
dpc-4148	235	2	transl	transl	PROPN
dpc-4148	235	3	med	med	PROPN
dpc-4148	235	4	.	.	PUNCT
dpc-4148	236	1	2021;9(5):437	2021;9(5):437	X
dpc-4148	236	2	.	.	PUNCT
dpc-4148	236	3	doi:10.21037	doi:10.21037	PROPN
dpc-4148	236	4	/	/	SYM
dpc-4148	236	5	atm-20	atm-20	NOUN
dpc-4148	236	6	-	-	PUNCT
dpc-4148	236	7	6222	6222	NUM
dpc-4148	236	8	18	18	NUM
dpc-4148	236	9	.	.	PUNCT
dpc-4148	237	1	arkachaisri	arkachaisri	PROPN
dpc-4148	237	2	t	t	PROPN
dpc-4148	237	3	,	,	PUNCT
dpc-4148	237	4	vilaiyuk	vilaiyuk	PROPN
dpc-4148	237	5	s	s	NOUN
dpc-4148	237	6	,	,	PUNCT
dpc-4148	237	7	torok	torok	PROPN
dpc-4148	237	8	ks	ks	PROPN
dpc-4148	237	9	,	,	PUNCT
dpc-4148	237	10	medsger	medsger	NOUN
dpc-4148	237	11	ta	ta	PROPN
dpc-4148	237	12	jr	jr	PROPN
dpc-4148	237	13	.	.	PUNCT
dpc-4148	237	14	development	development	NOUN
dpc-4148	237	15	and	and	CCONJ
dpc-4148	237	16	initial	initial	ADJ
dpc-4148	237	17	validation	validation	NOUN
dpc-4148	237	18	of	of	ADP
dpc-4148	237	19	the	the	DET
dpc-4148	237	20	localized	localize	VERB
dpc-4148	237	21	scleroderma	scleroderma	NOUN
dpc-4148	237	22	skin	skin	NOUN
dpc-4148	237	23	damage	damage	NOUN
dpc-4148	237	24	index	index	NOUN
dpc-4148	237	25	and	and	CCONJ
dpc-4148	237	26	physician	physician	NOUN
dpc-4148	237	27	global	global	ADJ
dpc-4148	237	28	assessment	assessment	NOUN
dpc-4148	237	29	of	of	ADP
dpc-4148	237	30	disease	disease	NOUN
dpc-4148	237	31	damage	damage	NOUN
dpc-4148	237	32	:	:	PUNCT
dpc-4148	237	33	a	a	DET
dpc-4148	237	34	proof	proof	NOUN
dpc-4148	237	35	-	-	PUNCT
dpc-4148	237	36	of	of	ADP
dpc-4148	237	37	-	-	PUNCT
dpc-4148	237	38	concept	concept	NOUN
dpc-4148	237	39	study	study	NOUN
dpc-4148	237	40	.	.	PUNCT
dpc-4148	238	1	rheumatology	rheumatology	NOUN
dpc-4148	238	2	.	.	PUNCT
dpc-4148	239	1	2010	2010	NUM
dpc-4148	239	2	,	,	PUNCT
dpc-4148	239	3	49(2	49(2	NUM
dpc-4148	239	4	)	)	PUNCT
dpc-4148	239	5	,	,	PUNCT
dpc-4148	240	1	373–381	373–381	NUM
dpc-4148	240	2	.	.	PUNCT
dpc-4148	240	3	doi	doi	NOUN
dpc-4148	240	4	:	:	PUNCT
dpc-4148	240	5	10.1093	10.1093	NUM
dpc-4148	240	6	/	/	SYM
dpc-4148	240	7	rheumatology	rheumatology	NOUN
dpc-4148	240	8	/	/	SYM
dpc-4148	240	9	kep361	kep361	PROPN
dpc-4148	240	10	.	.	PUNCT
dpc-4148	241	1	19	19	NUM
dpc-4148	241	2	.	.	NUM
dpc-4148	241	3	teske	teske	PROPN
dpc-4148	241	4	n	n	CCONJ
dpc-4148	241	5	,	,	PUNCT
dpc-4148	241	6	fett	fett	PROPN
dpc-4148	241	7	n.	n.	PROPN
dpc-4148	241	8	recent	recent	ADJ
dpc-4148	241	9	advances	advance	NOUN
dpc-4148	241	10	in	in	ADP
dpc-4148	241	11	treatment	treatment	NOUN
dpc-4148	241	12	of	of	ADP
dpc-4148	241	13	systemic	systemic	ADJ
dpc-4148	241	14	sclerosis	sclerosis	NOUN
dpc-4148	241	15	and	and	CCONJ
dpc-4148	241	16	morphea	morphea	PROPN
dpc-4148	241	17	.	.	PUNCT
dpc-4148	242	1	am	be	AUX
dpc-4148	242	2	j	j	PROPN
dpc-4148	242	3	clin	clin	PROPN
dpc-4148	242	4	dermatol	dermatol	NOUN
dpc-4148	242	5	.	.	PUNCT
dpc-4148	243	1	2024;25(2):213	2024;25(2):213	NUM
dpc-4148	243	2	-	-	SYM
dpc-4148	243	3	226	226	NUM
dpc-4148	243	4	.	.	PUNCT
dpc-4148	244	1	doi	doi	NOUN
dpc-4148	244	2	:	:	PUNCT
dpc-4148	244	3	10.1007	10.1007	NUM
dpc-4148	244	4	/	/	SYM
dpc-4148	244	5	s40257	s40257	NOUN
dpc-4148	244	6	-	-	PUNCT
dpc-4148	244	7	023	023	NUM
dpc-4148	244	8	-	-	PUNCT
dpc-4148	244	9	00831	00831	NUM
dpc-4148	244	10	-	-	SYM
dpc-4148	244	11	2	2	NUM
dpc-4148	244	12	.	.	NOUN
dpc-4148	244	13	20	20	NUM
dpc-4148	244	14	.	.	PUNCT
dpc-4148	245	1	lonati	lonati	PROPN
dpc-4148	245	2	pa	pa	PROPN
dpc-4148	245	3	,	,	PUNCT
dpc-4148	245	4	brembilla	brembilla	PROPN
dpc-4148	245	5	nc	nc	PROPN
dpc-4148	245	6	,	,	PUNCT
dpc-4148	245	7	montanari	montanari	PROPN
dpc-4148	245	8	e	e	PROPN
dpc-4148	245	9	,	,	PUNCT
dpc-4148	245	10	et	et	PROPN
dpc-4148	245	11	al	al	PROPN
dpc-4148	245	12	.	.	PROPN
dpc-4148	245	13	high	high	ADJ
dpc-4148	245	14	il-17e	il-17e	NOUN
dpc-4148	245	15	and	and	CCONJ
dpc-4148	245	16	low	low	ADJ
dpc-4148	245	17	il-17c	il-17c	NOUN
dpc-4148	245	18	dermal	dermal	NOUN
dpc-4148	245	19	expression	expression	NOUN
dpc-4148	245	20	identifies	identify	VERB
dpc-4148	245	21	a	a	DET
dpc-4148	245	22	fibrosis	fibrosis	NOUN
dpc-4148	245	23	-	-	PUNCT
dpc-4148	245	24	specific	specific	ADJ
dpc-4148	245	25	motif	motif	NOUN
dpc-4148	245	26	common	common	ADJ
dpc-4148	245	27	to	to	ADP
dpc-4148	245	28	morphea	morphea	PROPN
dpc-4148	245	29	and	and	CCONJ
dpc-4148	245	30	systemic	systemic	ADJ
dpc-4148	245	31	sclerosis	sclerosis	NOUN
dpc-4148	245	32	.	.	PUNCT
dpc-4148	246	1	plos	plos	PROPN
dpc-4148	246	2	one	one	NUM
dpc-4148	246	3	.	.	PUNCT
dpc-4148	246	4	2014	2014	NUM
dpc-4148	246	5	;	;	PUNCT
dpc-4148	246	6	19;9(8):e105008	19;9(8):e105008	PROPN
dpc-4148	246	7	.	.	PUNCT
dpc-4148	247	1	doi	doi	PROPN
dpc-4148	247	2	:	:	PUNCT
dpc-4148	247	3	10.1371	10.1371	NUM
dpc-4148	247	4	/	/	SYM
dpc-4148	247	5	journal.pone.0105008	journal.pone.0105008	NOUN
dpc-4148	247	6	.	.	PUNCT
dpc-4148	248	1	21	21	NUM
dpc-4148	248	2	.	.	PUNCT
dpc-4148	249	1	dańczak	dańczak	NOUN
dpc-4148	249	2	-	-	PUNCT
dpc-4148	249	3	pazdrowska	pazdrowska	PROPN
dpc-4148	249	4	a	a	NOUN
dpc-4148	249	5	,	,	PUNCT
dpc-4148	249	6	kowalczyk	kowalczyk	PROPN
dpc-4148	249	7	m	m	PROPN
dpc-4148	249	8	,	,	PUNCT
dpc-4148	249	9	szramka	szramka	NOUN
dpc-4148	249	10	-	-	PUNCT
dpc-4148	249	11	pawlak	pawlak	ADJ
dpc-4148	249	12	b	b	NOUN
dpc-4148	249	13	,	,	PUNCT
dpc-4148	249	14	et	et	PROPN
dpc-4148	249	15	al	al	PROPN
dpc-4148	249	16	.	.	PUNCT
dpc-4148	250	1	interleukin-17a	interleukin-17a	PROPN
dpc-4148	250	2	and	and	CCONJ
dpc-4148	250	3	interleukin-23	interleukin-23	PROPN
dpc-4148	250	4	in	in	ADP
dpc-4148	250	5	morphea	morphea	PROPN
dpc-4148	250	6	.	.	PUNCT
dpc-4148	251	1	arch	arch	PROPN
dpc-4148	251	2	med	med	PROPN
dpc-4148	251	3	sci	sci	PROPN
dpc-4148	251	4	.	.	PROPN
dpc-4148	251	5	2012	2012	NUM
dpc-4148	251	6	,	,	PUNCT
dpc-4148	251	7	20;8(6):1089	20;8(6):1089	NOUN
dpc-4148	251	8	-	-	SYM
dpc-4148	251	9	1095	1095	NUM
dpc-4148	251	10	.	.	PUNCT
dpc-4148	252	1	doi	doi	NOUN
dpc-4148	252	2	:	:	PUNCT
dpc-4148	252	3	10.5114	10.5114	NUM
dpc-4148	252	4	/	/	SYM
dpc-4148	252	5	aoms.2012.32421	aoms.2012.32421	PROPN
dpc-4148	252	6	.	.	PROPN
dpc-4148	253	1	22	22	NUM
dpc-4148	253	2	.	.	PUNCT
dpc-4148	254	1	bhattacharyya	bhattacharyya	PROPN
dpc-4148	254	2	s	s	PROPN
dpc-4148	254	3	,	,	PUNCT
dpc-4148	254	4	varga	varga	PROPN
dpc-4148	254	5	j.	j.	PROPN
dpc-4148	254	6	emerging	emerge	VERB
dpc-4148	254	7	roles	role	NOUN
dpc-4148	254	8	of	of	ADP
dpc-4148	254	9	innate	innate	ADJ
dpc-4148	254	10	immune	immune	ADJ
dpc-4148	254	11	signaling	signal	VERB
dpc-4148	254	12	and	and	CCONJ
dpc-4148	254	13	toll	toll	NOUN
dpc-4148	254	14	-	-	PUNCT
dpc-4148	254	15	like	like	ADJ
dpc-4148	254	16	receptors	receptor	NOUN
dpc-4148	254	17	in	in	ADP
dpc-4148	254	18	fibrosis	fibrosis	NOUN
dpc-4148	254	19	and	and	CCONJ
dpc-4148	254	20	systemic	systemic	ADJ
dpc-4148	254	21	sclerosis	sclerosis	NOUN
dpc-4148	254	22	.	.	PUNCT
dpc-4148	255	1	curr	curr	PROPN
dpc-4148	255	2	rheumatol	rheumatol	PROPN
dpc-4148	255	3	rep	rep	PROPN
dpc-4148	255	4	.	.	PROPN
dpc-4148	255	5	2015;17(1):474	2015;17(1):474	PROPN
dpc-4148	255	6	.	.	PUNCT
dpc-4148	256	1	doi	doi	NOUN
dpc-4148	256	2	:	:	PUNCT
dpc-4148	256	3	10.1007	10.1007	NUM
dpc-4148	256	4	/	/	SYM
dpc-4148	256	5	s11926	s11926	PROPN
dpc-4148	256	6	-014	-014	NOUN
dpc-4148	256	7	-	-	PUNCT
dpc-4148	256	8	0474	0474	NUM
dpc-4148	256	9	-	-	PUNCT
dpc-4148	256	10	z.	z.	PROPN
dpc-4148	256	11	23	23	NUM
dpc-4148	256	12	.	.	PUNCT
dpc-4148	257	1	agarwal	agarwal	PROPN
dpc-4148	257	2	sk	sk	PROPN
dpc-4148	257	3	,	,	PUNCT
dpc-4148	257	4	wu	wu	PROPN
dpc-4148	257	5	m	m	PROPN
dpc-4148	257	6	,	,	PUNCT
dpc-4148	257	7	livingston	livingston	PROPN
dpc-4148	257	8	ck	ck	PROPN
dpc-4148	257	9	,	,	PUNCT
dpc-4148	257	10	et	et	PROPN
dpc-4148	257	11	al	al	PROPN
dpc-4148	257	12	.	.	PUNCT
dpc-4148	258	1	toll	toll	NOUN
dpc-4148	258	2	-	-	PUNCT
dpc-4148	258	3	like	like	ADJ
dpc-4148	258	4	receptor	receptor	NOUN
dpc-4148	258	5	3	3	NUM
dpc-4148	258	6	upregulation	upregulation	NOUN
dpc-4148	258	7	by	by	ADP
dpc-4148	258	8	type	type	NOUN
dpc-4148	258	9	i	i	PRON
dpc-4148	258	10	interferon	interferon	ADJ
dpc-4148	258	11	in	in	ADP
dpc-4148	258	12	healthy	healthy	ADJ
dpc-4148	258	13	and	and	CCONJ
dpc-4148	258	14	scleroderma	scleroderma	VERB
dpc-4148	258	15	dermal	dermal	NOUN
dpc-4148	258	16	fibroblasts	fibroblast	NOUN
dpc-4148	258	17	.	.	PUNCT
dpc-4148	259	1	arthritis	arthritis	NOUN
dpc-4148	259	2	res	re	NOUN
dpc-4148	259	3	ther	ther	ADV
dpc-4148	259	4	.	.	PUNCT
dpc-4148	260	1	2011,11;13(1):r3	2011,11;13(1):r3	NOUN
dpc-4148	260	2	.	.	PUNCT
dpc-4148	261	1	doi	doi	NOUN
dpc-4148	261	2	:	:	PUNCT
dpc-4148	261	3	10.1186	10.1186	NUM
dpc-4148	261	4	/	/	SYM
dpc-4148	261	5	ar3221	ar3221	NOUN
dpc-4148	261	6	.	.	PUNCT
dpc-4148	262	1	24	24	NUM
dpc-4148	262	2	.	.	PUNCT
dpc-4148	263	1	koumakis	koumakis	PROPN
dpc-4148	263	2	e	e	PROPN
dpc-4148	263	3	,	,	PUNCT
dpc-4148	263	4	giraud	giraud	PROPN
dpc-4148	263	5	m	m	PROPN
dpc-4148	263	6	,	,	PUNCT
dpc-4148	263	7	dieude	dieude	VERB
dpc-4148	263	8	p	p	PRON
dpc-4148	263	9	,	,	PUNCT
dpc-4148	263	10	et	et	PROPN
dpc-4148	263	11	al	al	PROPN
dpc-4148	263	12	.	.	PROPN
dpc-4148	263	13	brief	brief	PROPN
dpc-4148	263	14	report	report	NOUN
dpc-4148	263	15	:	:	PUNCT
dpc-4148	263	16	candidate	candidate	NOUN
dpc-4148	263	17	gene	gene	NOUN
dpc-4148	263	18	study	study	NOUN
dpc-4148	263	19	in	in	ADP
dpc-4148	263	20	systemic	systemic	ADJ
dpc-4148	263	21	sclerosis	sclerosis	NOUN
dpc-4148	263	22	identifies	identify	VERB
dpc-4148	263	23	a	a	DET
dpc-4148	263	24	rare	rare	ADJ
dpc-4148	263	25	and	and	CCONJ
dpc-4148	263	26	functional	functional	ADJ
dpc-4148	263	27	emphasized	emphasize	VERB
dpc-4148	264	1	[	[	X
dpc-4148	264	2	37	37	NUM
dpc-4148	264	3	]	]	PUNCT
dpc-4148	264	4	.	.	PUNCT
dpc-4148	265	1	fibronectin	fibronectin	NOUN
dpc-4148	265	2	-	-	PUNCT
dpc-4148	265	3	eda	eda	PROPN
dpc-4148	265	4	and	and	CCONJ
dpc-4148	265	5	tenascin	tenascin	PROPN
dpc-4148	265	6	-	-	PUNCT
dpc-4148	265	7	c	c	NOUN
dpc-4148	265	8	are	be	AUX
dpc-4148	265	9	damps	damp	NOUN
dpc-4148	265	10	that	that	DET
dpc-4148	265	11	trigger	trigger	NOUN
dpc-4148	265	12	tlr4	tlr4	NOUN
dpc-4148	265	13	on	on	ADP
dpc-4148	265	14	resident	resident	ADJ
dpc-4148	265	15	cells	cell	NOUN
dpc-4148	265	16	,	,	PUNCT
dpc-4148	265	17	leading	lead	VERB
dpc-4148	265	18	to	to	ADP
dpc-4148	265	19	stimulation	stimulation	NOUN
dpc-4148	265	20	of	of	ADP
dpc-4148	265	21	fibrotic	fibrotic	ADJ
dpc-4148	265	22	gene	gene	NOUN
dpc-4148	265	23	expression	expression	NOUN
dpc-4148	265	24	and	and	CCONJ
dpc-4148	265	25	myofibroblast	myofibroblast	NOUN
dpc-4148	265	26	differentiation	differentiation	NOUN
dpc-4148	265	27	in	in	ADP
dpc-4148	265	28	systemic	systemic	ADJ
dpc-4148	265	29	scleroderma	scleroderma	NOUN
dpc-4148	265	30	.	.	PUNCT
dpc-4148	266	1	this	this	DET
dpc-4148	266	2	tlr4	tlr4	NOUN
dpc-4148	266	3	activation	activation	NOUN
dpc-4148	266	4	pathway	pathway	NOUN
dpc-4148	266	5	is	be	AUX
dpc-4148	266	6	a	a	DET
dpc-4148	266	7	potential	potential	ADJ
dpc-4148	266	8	target	target	NOUN
dpc-4148	266	9	for	for	ADP
dpc-4148	266	10	antifibrotic	antifibrotic	ADJ
dpc-4148	266	11	therapeutic	therapeutic	ADJ
dpc-4148	266	12	approaches	approach	NOUN
dpc-4148	266	13	in	in	ADP
dpc-4148	266	14	scleroderma	scleroderma	NOUN
dpc-4148	266	15	and	and	CCONJ
dpc-4148	266	16	sclerotic	sclerotic	ADJ
dpc-4148	266	17	diseases	disease	NOUN
dpc-4148	266	18	[	[	X
dpc-4148	266	19	29,38	29,38	X
dpc-4148	266	20	]	]	PUNCT
dpc-4148	266	21	.	.	PUNCT
dpc-4148	267	1	the	the	DET
dpc-4148	267	2	main	main	ADJ
dpc-4148	267	3	limitations	limitation	NOUN
dpc-4148	267	4	of	of	ADP
dpc-4148	267	5	our	our	PRON
dpc-4148	267	6	study	study	NOUN
dpc-4148	267	7	are	be	AUX
dpc-4148	267	8	that	that	SCONJ
dpc-4148	267	9	our	our	PRON
dpc-4148	267	10	number	number	NOUN
dpc-4148	267	11	of	of	ADP
dpc-4148	267	12	patients	patient	NOUN
dpc-4148	267	13	was	be	AUX
dpc-4148	267	14	relatively	relatively	ADV
dpc-4148	267	15	small	small	ADJ
dpc-4148	267	16	,	,	PUNCT
dpc-4148	267	17	and	and	CCONJ
dpc-4148	267	18	the	the	DET
dpc-4148	267	19	high	high	ADJ
dpc-4148	267	20	number	number	NOUN
dpc-4148	267	21	of	of	ADP
dpc-4148	267	22	allergic	allergic	ADJ
dpc-4148	267	23	conditions	condition	NOUN
dpc-4148	267	24	in	in	ADP
dpc-4148	267	25	the	the	DET
dpc-4148	267	26	patient	patient	NOUN
dpc-4148	267	27	group	group	NOUN
dpc-4148	267	28	may	may	AUX
dpc-4148	267	29	have	have	AUX
dpc-4148	267	30	affected	affect	VERB
dpc-4148	267	31	cytokine	cytokine	ADJ
dpc-4148	267	32	levels	level	NOUN
dpc-4148	267	33	,	,	PUNCT
dpc-4148	267	34	since	since	SCONJ
dpc-4148	267	35	th2	th2	PROPN
dpc-4148	267	36	-	-	PUNCT
dpc-4148	267	37	driven	drive	VERB
dpc-4148	267	38	diseases	disease	NOUN
dpc-4148	267	39	may	may	AUX
dpc-4148	267	40	influence	influence	VERB
dpc-4148	267	41	the	the	DET
dpc-4148	267	42	circulating	circulate	VERB
dpc-4148	267	43	levels	level	NOUN
dpc-4148	267	44	of	of	ADP
dpc-4148	267	45	several	several	ADJ
dpc-4148	267	46	cytokines	cytokine	NOUN
dpc-4148	267	47	such	such	ADJ
dpc-4148	267	48	as	as	ADP
dpc-4148	267	49	il-6	il-6	NUM
dpc-4148	267	50	or	or	CCONJ
dpc-4148	267	51	tgfbeta	tgfbeta	NOUN
dpc-4148	267	52	,	,	PUNCT
dpc-4148	267	53	which	which	PRON
dpc-4148	267	54	may	may	AUX
dpc-4148	267	55	be	be	AUX
dpc-4148	267	56	enhanced	enhance	VERB
dpc-4148	267	57	by	by	ADP
dpc-4148	267	58	il-4	il-4	X
dpc-4148	267	59	.	.	PUNCT
dpc-4148	268	1	an	an	DET
dpc-4148	268	2	additional	additional	ADJ
dpc-4148	268	3	limitation	limitation	NOUN
dpc-4148	268	4	may	may	AUX
dpc-4148	268	5	be	be	AUX
dpc-4148	268	6	that	that	SCONJ
dpc-4148	268	7	the	the	DET
dpc-4148	268	8	analysis	analysis	NOUN
dpc-4148	268	9	of	of	ADP
dpc-4148	268	10	histopathological	histopathological	ADJ
dpc-4148	268	11	parameters	parameter	NOUN
dpc-4148	268	12	could	could	AUX
dpc-4148	268	13	not	not	PART
dpc-4148	268	14	be	be	AUX
dpc-4148	268	15	performed	perform	VERB
dpc-4148	268	16	due	due	ADP
dpc-4148	268	17	to	to	ADP
dpc-4148	268	18	budget	budget	NOUN
dpc-4148	268	19	constraints	constraint	NOUN
dpc-4148	268	20	.	.	PUNCT
dpc-4148	269	1	conclusion	conclusion	NOUN
dpc-4148	269	2	our	our	PRON
dpc-4148	269	3	findings	finding	NOUN
dpc-4148	269	4	show	show	VERB
dpc-4148	269	5	that	that	SCONJ
dpc-4148	269	6	tlr	tlr	PROPN
dpc-4148	269	7	pathways	pathway	NOUN
dpc-4148	269	8	have	have	VERB
dpc-4148	269	9	important	important	ADJ
dpc-4148	269	10	roles	role	NOUN
dpc-4148	269	11	in	in	ADP
dpc-4148	269	12	the	the	DET
dpc-4148	269	13	pathogenesis	pathogenesis	NOUN
dpc-4148	269	14	of	of	ADP
dpc-4148	269	15	localized	localized	ADJ
dpc-4148	269	16	scleroderma	scleroderma	NOUN
dpc-4148	269	17	,	,	PUNCT
dpc-4148	269	18	similar	similar	ADJ
dpc-4148	269	19	to	to	ADP
dpc-4148	269	20	the	the	DET
dpc-4148	269	21	findings	finding	NOUN
dpc-4148	269	22	in	in	ADP
dpc-4148	269	23	the	the	DET
dpc-4148	269	24	systemic	systemic	ADJ
dpc-4148	269	25	scleroderma	scleroderma	NOUN
dpc-4148	269	26	literature	literature	NOUN
dpc-4148	269	27	,	,	PUNCT
dpc-4148	269	28	and	and	CCONJ
dpc-4148	269	29	we	we	PRON
dpc-4148	269	30	think	think	VERB
dpc-4148	269	31	that	that	SCONJ
dpc-4148	269	32	these	these	DET
dpc-4148	269	33	findings	finding	NOUN
dpc-4148	269	34	will	will	AUX
dpc-4148	269	35	form	form	VERB
dpc-4148	269	36	the	the	DET
dpc-4148	269	37	basis	basis	NOUN
dpc-4148	269	38	for	for	ADP
dpc-4148	269	39	the	the	DET
dpc-4148	269	40	future	future	ADJ
dpc-4148	269	41	development	development	NOUN
dpc-4148	269	42	of	of	ADP
dpc-4148	269	43	tlr	tlr	PROPN
dpc-4148	269	44	-	-	PUNCT
dpc-4148	269	45	based	base	VERB
dpc-4148	269	46	agents	agent	NOUN
dpc-4148	269	47	in	in	ADP
dpc-4148	269	48	the	the	DET
dpc-4148	269	49	treatment	treatment	NOUN
dpc-4148	269	50	of	of	ADP
dpc-4148	269	51	localized	localized	ADJ
dpc-4148	269	52	scleroderma	scleroderma	NOUN
dpc-4148	269	53	.	.	PUNCT
dpc-4148	270	1	references	reference	NOUN
dpc-4148	270	2	1	1	NUM
dpc-4148	270	3	.	.	PUNCT
dpc-4148	271	1	fett	fett	PROPN
dpc-4148	271	2	n	n	CCONJ
dpc-4148	271	3	,	,	PUNCT
dpc-4148	271	4	werth	werth	PROPN
dpc-4148	271	5	vp	vp	PROPN
dpc-4148	271	6	.	.	PUNCT
dpc-4148	271	7	update	update	NOUN
dpc-4148	271	8	on	on	ADP
dpc-4148	271	9	morphea	morphea	PROPN
dpc-4148	271	10	:	:	PUNCT
dpc-4148	271	11	part	part	PROPN
dpc-4148	271	12	i.	i.	PROPN
dpc-4148	271	13	epidemiology	epidemiology	PROPN
dpc-4148	271	14	,	,	PUNCT
dpc-4148	271	15	clinical	clinical	ADJ
dpc-4148	271	16	presentation	presentation	NOUN
dpc-4148	271	17	,	,	PUNCT
dpc-4148	271	18	and	and	CCONJ
dpc-4148	271	19	pathogenesis	pathogenesis	NOUN
dpc-4148	271	20	.	.	PUNCT
dpc-4148	272	1	j	j	PROPN
dpc-4148	272	2	am	be	AUX
dpc-4148	272	3	acad	acad	ADJ
dpc-4148	272	4	dermatol	dermatol	NOUN
dpc-4148	272	5	.	.	PUNCT
dpc-4148	273	1	2011	2011	NUM
dpc-4148	273	2	;	;	PUNCT
dpc-4148	273	3	64(2	64(2	NUM
dpc-4148	273	4	):	):	PUNCT
dpc-4148	273	5	217	217	NUM
dpc-4148	273	6	-	-	SYM
dpc-4148	273	7	230	230	NUM
dpc-4148	273	8	.	.	PUNCT
dpc-4148	274	1	doi:10.1016	doi:10.1016	PROPN
dpc-4148	274	2	/	/	SYM
dpc-4148	274	3	j.jaad.2010.05.045	j.jaad.2010.05.045	PROPN
dpc-4148	274	4	2	2	NUM
dpc-4148	274	5	.	.	PUNCT
dpc-4148	274	6	laxer	laxer	PROPN
dpc-4148	274	7	rm	rm	PROPN
dpc-4148	274	8	,	,	PUNCT
dpc-4148	274	9	zulian	zulian	PROPN
dpc-4148	274	10	f.	f.	PROPN
dpc-4148	274	11	localized	localize	VERB
dpc-4148	274	12	scleroderma	scleroderma	NOUN
dpc-4148	274	13	.	.	PUNCT
dpc-4148	275	1	curr	curr	PROPN
dpc-4148	275	2	opin	opin	PROPN
dpc-4148	275	3	rheumatol	rheumatol	NOUN
dpc-4148	275	4	.	.	PUNCT
dpc-4148	276	1	2006;18(6):606–13	2006;18(6):606–13	NUM
dpc-4148	276	2	.	.	PUNCT
dpc-4148	276	3	doi:10.1097/01.bor	doi:10.1097/01.bor	NOUN
dpc-4148	276	4	.	.	PUNCT
dpc-4148	276	5	0000245727.40630.c3	0000245727.40630.c3	PROPN
dpc-4148	276	6	3	3	NUM
dpc-4148	276	7	.	.	PUNCT
dpc-4148	277	1	florez	florez	PROPN
dpc-4148	277	2	-	-	PUNCT
dpc-4148	277	3	pollack	pollack	PROPN
dpc-4148	277	4	s	s	PROPN
dpc-4148	277	5	,	,	PUNCT
dpc-4148	277	6	kunzler	kunzler	PROPN
dpc-4148	277	7	e	e	NOUN
dpc-4148	277	8	,	,	PUNCT
dpc-4148	277	9	jacobe	jacobe	PROPN
dpc-4148	277	10	ht	ht	PROPN
dpc-4148	277	11	.	.	PUNCT
dpc-4148	277	12	morphea	morphea	PROPN
dpc-4148	277	13	:	:	PUNCT
dpc-4148	277	14	current	current	ADJ
dpc-4148	277	15	concepts	concept	NOUN
dpc-4148	277	16	.	.	PUNCT
dpc-4148	278	1	clin	clin	PROPN
dpc-4148	278	2	dermatol	dermatol	NOUN
dpc-4148	278	3	.	.	PUNCT
dpc-4148	279	1	2018;36(4):475	2018;36(4):475	NUM
dpc-4148	279	2	-	-	SYM
dpc-4148	279	3	486	486	NUM
dpc-4148	279	4	.	.	PUNCT
dpc-4148	280	1	doi:10.1016	doi:10.1016	PROPN
dpc-4148	280	2	/j.clindermatol.2018.04.005	/j.clindermatol.2018.04.005	PUNCT
dpc-4148	281	1	4	4	X
dpc-4148	281	2	.	.	X
dpc-4148	281	3	brown	brown	PROPN
dpc-4148	281	4	m	m	PROPN
dpc-4148	281	5	,	,	PUNCT
dpc-4148	281	6	o’reilly	o’reilly	ADV
dpc-4148	281	7	s.	s.	PROPN
dpc-4148	281	8	innate	innate	VERB
dpc-4148	281	9	immunity	immunity	NOUN
dpc-4148	281	10	and	and	CCONJ
dpc-4148	281	11	toll	toll	NOUN
dpc-4148	281	12	-	-	PUNCT
dpc-4148	281	13	like	like	ADJ
dpc-4148	281	14	receptor	receptor	NOUN
dpc-4148	281	15	signaling	signal	VERB
dpc-4148	281	16	in	in	ADP
dpc-4148	281	17	the	the	DET
dpc-4148	281	18	pathogenesis	pathogenesis	NOUN
dpc-4148	281	19	of	of	ADP
dpc-4148	281	20	scleroderma	scleroderma	NOUN
dpc-4148	281	21	:	:	PUNCT
dpc-4148	281	22	advances	advance	NOUN
dpc-4148	281	23	and	and	CCONJ
dpc-4148	281	24	opportunities	opportunity	NOUN
dpc-4148	281	25	for	for	ADP
dpc-4148	281	26	therapy	therapy	NOUN
dpc-4148	281	27	.	.	PUNCT
dpc-4148	282	1	curr	curr	PROPN
dpc-4148	282	2	opin	opin	PROPN
dpc-4148	282	3	rheumatol	rheumatol	NOUN
dpc-4148	282	4	.	.	PUNCT
dpc-4148	283	1	2018	2018	NUM
dpc-4148	283	2	;	;	PUNCT
dpc-4148	284	1	30(6	30(6	NUM
dpc-4148	284	2	):	):	PUNCT
dpc-4148	284	3	600	600	NUM
dpc-4148	284	4	-	-	SYM
dpc-4148	284	5	605	605	NUM
dpc-4148	284	6	.	.	PUNCT
dpc-4148	285	1	doi	doi	NOUN
dpc-4148	285	2	:	:	PUNCT
dpc-4148	285	3	10.1097	10.1097	NUM
dpc-4148	285	4	/	/	SYM
dpc-4148	285	5	bor.0000000000000542	bor.0000000000000542	NOUN
dpc-4148	285	6	.	.	PUNCT
dpc-4148	286	1	5	5	NUM
dpc-4148	286	2	.	.	X
dpc-4148	286	3	kawai	kawai	PROPN
dpc-4148	286	4	t	t	PROPN
dpc-4148	286	5	,	,	PUNCT
dpc-4148	286	6	akira	akira	PROPN
dpc-4148	286	7	s.	s.	PROPN
dpc-4148	286	8	toll	toll	PROPN
dpc-4148	286	9	-	-	PUNCT
dpc-4148	286	10	like	like	ADJ
dpc-4148	286	11	receptors	receptor	NOUN
dpc-4148	286	12	and	and	CCONJ
dpc-4148	286	13	their	their	PRON
dpc-4148	286	14	crosstalk	crosstalk	NOUN
dpc-4148	286	15	with	with	ADP
dpc-4148	286	16	other	other	ADJ
dpc-4148	286	17	innate	innate	ADJ
dpc-4148	286	18	receptors	receptor	NOUN
dpc-4148	286	19	in	in	ADP
dpc-4148	286	20	infection	infection	NOUN
dpc-4148	286	21	and	and	CCONJ
dpc-4148	286	22	immunity	immunity	NOUN
dpc-4148	286	23	.	.	PUNCT
dpc-4148	287	1	immunity	immunity	NOUN
dpc-4148	287	2	.	.	PUNCT
dpc-4148	288	1	2011;34(5	2011;34(5	NUM
dpc-4148	288	2	):	):	PUNCT
dpc-4148	289	1	637–650	637–650	NUM
dpc-4148	289	2	.	.	PUNCT
dpc-4148	290	1	doi	doi	NOUN
dpc-4148	290	2	:	:	PUNCT
dpc-4148	290	3	10.1016	10.1016	NUM
dpc-4148	290	4	/	/	SYM
dpc-4148	290	5	j.immuni.2011.05.006	j.immuni.2011.05.006	PROPN
dpc-4148	290	6	.	.	PUNCT
dpc-4148	291	1	pmid	pmid	NOUN
dpc-4148	291	2	:	:	PUNCT
dpc-4148	291	3	21616434	21616434	NUM
dpc-4148	291	4	.	.	PUNCT
dpc-4148	292	1	6	6	X
dpc-4148	292	2	.	.	X
dpc-4148	292	3	abdelsadik	abdelsadik	PROPN
dpc-4148	292	4	a	a	PRON
dpc-4148	292	5	,	,	PUNCT
dpc-4148	292	6	trad	trad	NOUN
dpc-4148	292	7	a.	a.	NOUN
dpc-4148	292	8	toll	toll	NOUN
dpc-4148	292	9	-	-	PUNCT
dpc-4148	292	10	like	like	ADJ
dpc-4148	292	11	receptors	receptor	NOUN
dpc-4148	292	12	on	on	ADP
dpc-4148	292	13	the	the	DET
dpc-4148	292	14	fork	fork	NOUN
dpc-4148	292	15	roads	road	NOUN
dpc-4148	292	16	between	between	ADP
dpc-4148	292	17	innate	innate	ADJ
dpc-4148	292	18	and	and	CCONJ
dpc-4148	292	19	adaptive	adaptive	ADJ
dpc-4148	292	20	immunity	immunity	NOUN
dpc-4148	292	21	.	.	PUNCT
dpc-4148	293	1	hum	hum	PROPN
dpc-4148	293	2	immunol	immunol	NOUN
dpc-4148	293	3	.	.	PUNCT
dpc-4148	294	1	2011;72(12):1188	2011;72(12):1188	NUM
dpc-4148	294	2	-	-	SYM
dpc-4148	294	3	1193	1193	NUM
dpc-4148	294	4	.	.	PUNCT
dpc-4148	295	1	doi	doi	NOUN
dpc-4148	295	2	:	:	PUNCT
dpc-4148	295	3	10.1016	10.1016	NUM
dpc-4148	295	4	/	/	SYM
dpc-4148	295	5	j.humimm.2011.08.015	j.humimm.2011.08.015	PROPN
dpc-4148	295	6	.	.	PROPN
dpc-4148	296	1	7	7	NUM
dpc-4148	296	2	.	.	X
dpc-4148	296	3	roelofs	roelof	NOUN
dpc-4148	296	4	mf	mf	VERB
dpc-4148	296	5	lj	lj	PROPN
dpc-4148	296	6	,	,	PUNCT
dpc-4148	296	7	abdollahi	abdollahi	NOUN
dpc-4148	296	8	-	-	PUNCT
dpc-4148	296	9	roodsaz	roodsaz	NOUN
dpc-4148	296	10	s	s	PROPN
dpc-4148	296	11	,	,	PUNCT
dpc-4148	296	12	van	van	PROPN
dpc-4148	296	13	lieshout	lieshout	PROPN
dpc-4148	296	14	awt	awt	PROPN
dpc-4148	296	15	,	,	PUNCT
dpc-4148	296	16	radstake	radstake	NOUN
dpc-4148	296	17	trdj	trdj	NOUN
dpc-4148	296	18	,	,	PUNCT
dpc-4148	296	19	van	van	PROPN
dpc-4148	296	20	den	den	PROPN
dpc-4148	296	21	berg	berg	PROPN
dpc-4148	296	22	wb	wb	PROPN
dpc-4148	296	23	.	.	PROPN
dpc-4148	296	24	expression	expression	NOUN
dpc-4148	296	25	of	of	ADP
dpc-4148	296	26	toll	toll	NOUN
dpc-4148	296	27	-	-	PUNCT
dpc-4148	296	28	like	like	ADJ
dpc-4148	296	29	receptor	receptor	NOUN
dpc-4148	296	30	(	(	PUNCT
dpc-4148	296	31	tlr	tlr	PROPN
dpc-4148	296	32	)	)	PUNCT
dpc-4148	296	33	2	2	NUM
dpc-4148	296	34	,	,	PUNCT
dpc-4148	296	35	tlr3	tlr3	NOUN
dpc-4148	296	36	,	,	PUNCT
dpc-4148	296	37	tlr4	tlr4	NOUN
dpc-4148	296	38	and	and	CCONJ
dpc-4148	296	39	tlr7	tlr7	NOUN
dpc-4148	296	40	is	be	AUX
dpc-4148	296	41	increased	increase	VERB
dpc-4148	296	42	in	in	ADP
dpc-4148	296	43	rheumatoid	rheumatoid	NOUN
dpc-4148	296	44	arthritis	arthritis	NOUN
dpc-4148	296	45	synovium	synovium	NOUN
dpc-4148	296	46	and	and	CCONJ
dpc-4148	296	47	regulates	regulate	VERB
dpc-4148	296	48	cytokine	cytokine	ADJ
dpc-4148	296	49	production	production	NOUN
dpc-4148	296	50	by	by	ADP
dpc-4148	296	51	dendritic	dendritic	ADJ
dpc-4148	296	52	cells	cell	NOUN
dpc-4148	296	53	upon	upon	SCONJ
dpc-4148	296	54	stimulation	stimulation	NOUN
dpc-4148	296	55	of	of	ADP
dpc-4148	296	56	tlr	tlr	PROPN
dpc-4148	296	57	specific	specific	ADJ
dpc-4148	296	58	pathways	pathway	NOUN
dpc-4148	296	59	.	.	PUNCT
dpc-4148	297	1	arthritis	arthritis	NOUN
dpc-4148	297	2	res	re	NOUN
dpc-4148	297	3	ther	ther	ADV
dpc-4148	297	4	.	.	PUNCT
dpc-4148	298	1	2005;7:70	2005;7:70	NOUN
dpc-4148	298	2	.	.	PUNCT
dpc-4148	299	1	doi	doi	NOUN
dpc-4148	299	2	:	:	PUNCT
dpc-4148	299	3	10.1002	10.1002	NUM
dpc-4148	299	4	/	/	SYM
dpc-4148	299	5	art.21278	art.21278	PROPN
dpc-4148	299	6	.	.	NOUN
dpc-4148	299	7	8	8	NUM
dpc-4148	299	8	.	.	X
dpc-4148	300	1	pasare	pasare	NOUN
dpc-4148	300	2	c	c	NOUN
dpc-4148	300	3	,	,	PUNCT
dpc-4148	300	4	medzhitov	medzhitov	PROPN
dpc-4148	300	5	r.	r.	PROPN
dpc-4148	300	6	toll	toll	NOUN
dpc-4148	300	7	-	-	PUNCT
dpc-4148	300	8	like	like	ADJ
dpc-4148	300	9	receptors	receptor	NOUN
dpc-4148	300	10	:	:	PUNCT
dpc-4148	300	11	linking	link	VERB
dpc-4148	300	12	innate	innate	ADJ
dpc-4148	300	13	and	and	CCONJ
dpc-4148	300	14	adaptive	adaptive	ADJ
dpc-4148	300	15	immunity	immunity	NOUN
dpc-4148	300	16	.	.	PUNCT
dpc-4148	301	1	adv	adv	PROPN
dpc-4148	301	2	exp	exp	NOUN
dpc-4148	301	3	med	med	ADJ
dpc-4148	301	4	biol	biol	NOUN
dpc-4148	301	5	.	.	PUNCT
dpc-4148	302	1	2005	2005	NUM
dpc-4148	302	2	;	;	PUNCT
dpc-4148	303	1	560:11	560:11	NUM
dpc-4148	303	2	-	-	SYM
dpc-4148	303	3	18	18	NUM
dpc-4148	303	4	.	.	PUNCT
dpc-4148	304	1	doi	doi	NOUN
dpc-4148	304	2	:	:	PUNCT
dpc-4148	304	3	10.1007/0	10.1007/0	NUM
dpc-4148	304	4	-	-	PUNCT
dpc-4148	304	5	387	387	NUM
dpc-4148	304	6	-	-	PUNCT
dpc-4148	304	7	24180	24180	NUM
dpc-4148	304	8	-	-	PUNCT
dpc-4148	304	9	9_2	9_2	NUM
dpc-4148	304	10	.	.	PUNCT
dpc-4148	305	1	9	9	X
dpc-4148	305	2	.	.	X
dpc-4148	305	3	geurts	geurts	PROPN
dpc-4148	305	4	j	j	PROPN
dpc-4148	305	5	,	,	PUNCT
dpc-4148	305	6	van	van	PROPN
dpc-4148	305	7	den	den	PROPN
dpc-4148	305	8	brand	brand	PROPN
dpc-4148	305	9	bt	bt	PROPN
dpc-4148	305	10	,	,	PUNCT
dpc-4148	305	11	wolf	wolf	PROPN
dpc-4148	305	12	a	a	PRON
dpc-4148	305	13	,	,	PUNCT
dpc-4148	305	14	et	et	PROPN
dpc-4148	305	15	al	al	PROPN
dpc-4148	305	16	.	.	PUNCT
dpc-4148	306	1	toll	toll	NOUN
dpc-4148	306	2	-	-	PUNCT
dpc-4148	306	3	like	like	ADJ
dpc-4148	306	4	receptor	receptor	NOUN
dpc-4148	306	5	4	4	NUM
dpc-4148	306	6	signalling	signal	VERB
dpc-4148	306	7	is	be	AUX
dpc-4148	306	8	specifically	specifically	ADV
dpc-4148	306	9	tgf	tgf	NOUN
dpc-4148	306	10	-	-	PUNCT
dpc-4148	306	11	beta	beta	NOUN
dpc-4148	306	12	-	-	PUNCT
dpc-4148	306	13	activated	activate	VERB
dpc-4148	306	14	kinase	kinase	NOUN
dpc-4148	306	15	1	1	NUM
dpc-4148	306	16	independent	independent	ADJ
dpc-4148	306	17	original	original	ADJ
dpc-4148	306	18	article	article	NOUN
dpc-4148	306	19	|	|	ADV
dpc-4148	306	20	dermatol	dermatol	ADJ
dpc-4148	306	21	pract	pract	NOUN
dpc-4148	306	22	concept	concept	NOUN
dpc-4148	306	23	.	.	PUNCT
dpc-4148	307	1	2024;14(4):e2024219	2024;14(4):e2024219	NUM
dpc-4148	307	2	9	9	NUM
dpc-4148	307	3	32	32	NUM
dpc-4148	307	4	.	.	PUNCT
dpc-4148	308	1	das	das	PROPN
dpc-4148	308	2	n	n	CCONJ
dpc-4148	308	3	,	,	PUNCT
dpc-4148	308	4	dewan	dewan	PROPN
dpc-4148	308	5	v	v	NOUN
dpc-4148	308	6	,	,	PUNCT
dpc-4148	308	7	grace	grace	NOUN
dpc-4148	308	8	pm	pm	NOUN
dpc-4148	308	9	et	et	PROPN
dpc-4148	308	10	al	al	PROPN
dpc-4148	308	11	.	.	PUNCT
dpc-4148	308	12	hmgb1	hmgb1	PROPN
dpc-4148	308	13	activates	activate	VERB
dpc-4148	308	14	proinflammatory	proinflammatory	ADJ
dpc-4148	308	15	signaling	signal	VERB
dpc-4148	308	16	via	via	ADP
dpc-4148	308	17	tlr5	tlr5	PROPN
dpc-4148	308	18	leading	lead	VERB
dpc-4148	308	19	to	to	ADP
dpc-4148	308	20	allodynia	allodynia	PROPN
dpc-4148	308	21	.	.	PUNCT
dpc-4148	309	1	cell	cell	PROPN
dpc-4148	309	2	rep	rep	PROPN
dpc-4148	309	3	.	.	PROPN
dpc-4148	309	4	2016	2016	NUM
dpc-4148	310	1	;	;	PUNCT
dpc-4148	310	2	17:1128–1140	17:1128–1140	NUM
dpc-4148	310	3	.	.	PUNCT
dpc-4148	310	4	doi	doi	PROPN
dpc-4148	310	5	:	:	PUNCT
dpc-4148	310	6	10.1016	10.1016	NUM
dpc-4148	310	7	/	/	SYM
dpc-4148	310	8	j.celrep.2016.09.076	j.celrep.2016.09.076	PROPN
dpc-4148	310	9	.	.	PUNCT
dpc-4148	311	1	33	33	NUM
dpc-4148	311	2	.	.	PUNCT
dpc-4148	312	1	hasan	hasan	PROPN
dpc-4148	312	2	u	u	PROPN
dpc-4148	312	3	,	,	PUNCT
dpc-4148	312	4	chaffois	chaffois	PROPN
dpc-4148	312	5	c	c	X
dpc-4148	312	6	,	,	PUNCT
dpc-4148	312	7	gaillard	gaillard	PROPN
dpc-4148	312	8	c	c	PROPN
dpc-4148	312	9	et	et	PROPN
dpc-4148	312	10	al	al	PROPN
dpc-4148	312	11	.	.	PROPN
dpc-4148	313	1	human	human	PROPN
dpc-4148	313	2	tlr10	tlr10	PROPN
dpc-4148	313	3	is	be	AUX
dpc-4148	313	4	a	a	DET
dpc-4148	313	5	functional	functional	ADJ
dpc-4148	313	6	receptor	receptor	NOUN
dpc-4148	313	7	,	,	PUNCT
dpc-4148	313	8	expressed	express	VERB
dpc-4148	313	9	by	by	ADP
dpc-4148	313	10	b	b	PROPN
dpc-4148	313	11	cells	cell	NOUN
dpc-4148	313	12	and	and	CCONJ
dpc-4148	313	13	plasmacytoid	plasmacytoid	VERB
dpc-4148	313	14	dendritic	dendritic	ADJ
dpc-4148	313	15	cells	cell	NOUN
dpc-4148	313	16	,	,	PUNCT
dpc-4148	313	17	which	which	PRON
dpc-4148	313	18	activates	activate	VERB
dpc-4148	313	19	gene	gene	NOUN
dpc-4148	313	20	transcription	transcription	NOUN
dpc-4148	313	21	through	through	ADP
dpc-4148	313	22	myd88	myd88	PROPN
dpc-4148	313	23	.	.	PUNCT
dpc-4148	314	1	j	j	PROPN
dpc-4148	314	2	immunol	immunol	NOUN
dpc-4148	314	3	.	.	PUNCT
dpc-4148	315	1	2005	2005	NUM
dpc-4148	315	2	;	;	PUNCT
dpc-4148	315	3	174:2942–2950	174:2942–2950	NUM
dpc-4148	315	4	.	.	PUNCT
dpc-4148	316	1	doi	doi	NOUN
dpc-4148	316	2	:	:	PUNCT
dpc-4148	316	3	10.4049	10.4049	NUM
dpc-4148	316	4	/	/	SYM
dpc-4148	316	5	jimmunol.174	jimmunol.174	X
dpc-4148	316	6	.	.	PUNCT
dpc-4148	317	1	5.2942	5.2942	NUM
dpc-4148	317	2	.	.	PUNCT
dpc-4148	318	1	34	34	NUM
dpc-4148	318	2	.	.	PUNCT
dpc-4148	319	1	lee	lee	PROPN
dpc-4148	319	2	sm	sm	PROPN
dpc-4148	319	3	,	,	PUNCT
dpc-4148	319	4	yip	yip	PROPN
dpc-4148	319	5	tf	tf	PROPN
dpc-4148	319	6	,	,	PUNCT
dpc-4148	319	7	yan	yan	PROPN
dpc-4148	319	8	s	s	PART
dpc-4148	319	9	et	et	PROPN
dpc-4148	319	10	al	al	PROPN
dpc-4148	319	11	.	.	PUNCT
dpc-4148	319	12	recognition	recognition	NOUN
dpc-4148	319	13	of	of	ADP
dpc-4148	319	14	double	double	ADJ
dpc-4148	319	15	-	-	PUNCT
dpc-4148	319	16	stranded	strand	VERB
dpc-4148	319	17	rna	rna	NOUN
dpc-4148	319	18	and	and	CCONJ
dpc-4148	319	19	regulation	regulation	NOUN
dpc-4148	319	20	of	of	ADP
dpc-4148	319	21	interferon	interferon	ADJ
dpc-4148	319	22	pathway	pathway	NOUN
dpc-4148	319	23	by	by	ADP
dpc-4148	319	24	toll	toll	NOUN
dpc-4148	319	25	-	-	PUNCT
dpc-4148	319	26	like	like	ADJ
dpc-4148	319	27	receptor	receptor	NOUN
dpc-4148	319	28	10	10	NUM
dpc-4148	319	29	.	.	PUNCT
dpc-4148	320	1	front	front	ADJ
dpc-4148	320	2	immuno.l	immuno.l	NOUN
dpc-4148	320	3	2018	2018	NUM
dpc-4148	320	4	;	;	PUNCT
dpc-4148	320	5	9:516	9:516	NUM
dpc-4148	320	6	.	.	PUNCT
dpc-4148	321	1	doi	doi	NOUN
dpc-4148	321	2	:	:	PUNCT
dpc-4148	321	3	10.3389	10.3389	NUM
dpc-4148	321	4	/	/	SYM
dpc-4148	321	5	fimmu.2018	fimmu.2018	PROPN
dpc-4148	321	6	.00516	.00516	ADJ
dpc-4148	321	7	.	.	PUNCT
dpc-4148	322	1	35	35	NUM
dpc-4148	322	2	.	.	X
dpc-4148	322	3	fang	fang	PROPN
dpc-4148	322	4	f	f	PROPN
dpc-4148	322	5	,	,	PUNCT
dpc-4148	322	6	marangoni	marangoni	NOUN
dpc-4148	322	7	rg	rg	PROPN
dpc-4148	322	8	,	,	PUNCT
dpc-4148	322	9	zhou	zhou	PROPN
dpc-4148	322	10	x	x	PUNCT
dpc-4148	322	11	et	et	PROPN
dpc-4148	322	12	al	al	PROPN
dpc-4148	322	13	.	.	PUNCT
dpc-4148	322	14	toll	toll	NOUN
dpc-4148	322	15	-	-	PUNCT
dpc-4148	322	16	like	like	ADJ
dpc-4148	322	17	receptor	receptor	NOUN
dpc-4148	322	18	9	9	NUM
dpc-4148	322	19	signaling	signal	VERB
dpc-4148	322	20	is	be	AUX
dpc-4148	322	21	augmented	augment	VERB
dpc-4148	322	22	in	in	ADP
dpc-4148	322	23	systemic	systemic	ADJ
dpc-4148	322	24	sclerosis	sclerosis	NOUN
dpc-4148	322	25	and	and	CCONJ
dpc-4148	322	26	elicits	elicit	VERB
dpc-4148	322	27	transforming	transform	VERB
dpc-4148	322	28	growth	growth	NOUN
dpc-4148	322	29	factor	factor	NOUN
dpc-4148	322	30	beta	beta	NOUN
dpc-4148	322	31	-	-	PUNCT
dpc-4148	322	32	dependent	dependent	ADJ
dpc-4148	322	33	fibroblast	fibroblast	ADJ
dpc-4148	322	34	activation	activation	NOUN
dpc-4148	322	35	.	.	PUNCT
dpc-4148	323	1	arthritis	arthritis	NOUN
dpc-4148	323	2	rheumatol	rheumatol	NOUN
dpc-4148	323	3	.	.	PUNCT
dpc-4148	324	1	2016	2016	NUM
dpc-4148	324	2	;	;	PUNCT
dpc-4148	324	3	68:1989–2002	68:1989–2002	NUM
dpc-4148	324	4	.	.	PUNCT
dpc-4148	325	1	doi	doi	NOUN
dpc-4148	325	2	:	:	PUNCT
dpc-4148	325	3	10.1002	10.1002	NUM
dpc-4148	325	4	/	/	SYM
dpc-4148	325	5	art.39655	art.39655	PROPN
dpc-4148	325	6	.	.	PROPN
dpc-4148	325	7	36	36	NUM
dpc-4148	325	8	.	.	X
dpc-4148	326	1	vreca	vreca	VERB
dpc-4148	326	2	m	m	PROPN
dpc-4148	326	3	,	,	PUNCT
dpc-4148	326	4	zekovic	zekovic	PROPN
dpc-4148	326	5	a	a	PRON
dpc-4148	326	6	,	,	PUNCT
dpc-4148	326	7	damjanov	damjanov	NOUN
dpc-4148	326	8	n	n	PROPN
dpc-4148	326	9	et	et	PROPN
dpc-4148	326	10	al	al	PROPN
dpc-4148	326	11	.	.	PUNCT
dpc-4148	326	12	expression	expression	NOUN
dpc-4148	326	13	of	of	ADP
dpc-4148	326	14	tlr7	tlr7	PROPN
dpc-4148	326	15	,	,	PUNCT
dpc-4148	326	16	tlr9	tlr9	PROPN
dpc-4148	326	17	,	,	PUNCT
dpc-4148	326	18	jak2	jak2	NOUN
dpc-4148	326	19	,	,	PUNCT
dpc-4148	326	20	and	and	CCONJ
dpc-4148	326	21	stat3	stat3	NOUN
dpc-4148	326	22	genes	gene	NOUN
dpc-4148	326	23	in	in	ADP
dpc-4148	326	24	peripheral	peripheral	ADJ
dpc-4148	326	25	blood	blood	NOUN
dpc-4148	326	26	mononuclear	mononuclear	ADJ
dpc-4148	326	27	cells	cell	NOUN
dpc-4148	326	28	from	from	ADP
dpc-4148	326	29	patients	patient	NOUN
dpc-4148	326	30	with	with	ADP
dpc-4148	326	31	systemic	systemic	ADJ
dpc-4148	326	32	sclerosis	sclerosis	NOUN
dpc-4148	326	33	.	.	PUNCT
dpc-4148	327	1	j	j	PROPN
dpc-4148	327	2	appl	appl	PROPN
dpc-4148	327	3	genet	genet	PROPN
dpc-4148	327	4	.	.	PUNCT
dpc-4148	328	1	2018	2018	NUM
dpc-4148	328	2	;	;	PUNCT
dpc-4148	329	1	59:59–66	59:59–66	NUM
dpc-4148	329	2	.	.	PUNCT
dpc-4148	330	1	doi	doi	NOUN
dpc-4148	330	2	:	:	PUNCT
dpc-4148	330	3	10.1007	10.1007	NUM
dpc-4148	330	4	/	/	SYM
dpc-4148	330	5	s13353	s13353	PROPN
dpc-4148	330	6	-	-	PUNCT
dpc-4148	330	7	017	017	NUM
dpc-4148	330	8	-	-	PUNCT
dpc-4148	330	9	0415	0415	NUM
dpc-4148	330	10	-	-	PUNCT
dpc-4148	330	11	4	4	NUM
dpc-4148	330	12	.	.	NOUN
dpc-4148	330	13	37	37	NUM
dpc-4148	330	14	.	.	PUNCT
dpc-4148	331	1	o’reilly	o’reilly	PROPN
dpc-4148	331	2	s	s	PART
dpc-4148	331	3	,	,	PUNCT
dpc-4148	331	4	ca	can	AUX
dpc-4148	331	5	nt	not	PART
dpc-4148	331	6	r	r	VERB
dpc-4148	331	7	,	,	PUNCT
dpc-4148	331	8	ciechomska	ciechomska	X
dpc-4148	331	9	m	m	VERB
dpc-4148	331	10	et	et	PROPN
dpc-4148	331	11	al	al	PROPN
dpc-4148	331	12	.	.	PROPN
dpc-4148	331	13	serum	serum	PROPN
dpc-4148	331	14	amyloid	amyloid	PROPN
dpc-4148	331	15	a	a	DET
dpc-4148	331	16	induces	induce	VERB
dpc-4148	331	17	interleukin-6	interleukin-6	PRON
dpc-4148	331	18	in	in	ADP
dpc-4148	331	19	dermal	dermal	ADJ
dpc-4148	331	20	fibroblasts	fibroblast	NOUN
dpc-4148	331	21	via	via	ADP
dpc-4148	331	22	toll	toll	NOUN
dpc-4148	331	23	-	-	PUNCT
dpc-4148	331	24	like	like	ADJ
dpc-4148	331	25	receptor	receptor	NOUN
dpc-4148	331	26	2	2	NUM
dpc-4148	331	27	,	,	PUNCT
dpc-4148	331	28	interleukin-1	interleukin-1	NOUN
dpc-4148	331	29	receptor	receptor	NOUN
dpc-4148	331	30	-	-	PUNCT
dpc-4148	331	31	associated	associate	VERB
dpc-4148	331	32	kinase	kinase	NOUN
dpc-4148	331	33	4	4	NUM
dpc-4148	331	34	and	and	CCONJ
dpc-4148	331	35	nuclear	nuclear	ADJ
dpc-4148	331	36	factor	factor	NOUN
dpc-4148	331	37	-	-	PUNCT
dpc-4148	331	38	κb	κb	NOUN
dpc-4148	331	39	.	.	PUNCT
dpc-4148	332	1	immunology	immunology	NOUN
dpc-4148	332	2	.	.	PUNCT
dpc-4148	333	1	2014	2014	NUM
dpc-4148	333	2	;	;	PUNCT
dpc-4148	333	3	143:331–340	143:331–340	NUM
dpc-4148	333	4	.	.	PUNCT
dpc-4148	334	1	doi	doi	NOUN
dpc-4148	334	2	:	:	PUNCT
dpc-4148	334	3	10.1111	10.1111	NUM
dpc-4148	334	4	/	/	SYM
dpc-4148	334	5	imm	imm	NOUN
dpc-4148	334	6	.12260	.12260	NOUN
dpc-4148	334	7	.	.	PUNCT
dpc-4148	335	1	38	38	NUM
dpc-4148	335	2	.	.	PUNCT
dpc-4148	336	1	bhattacharyya	bhattacharyya	PROPN
dpc-4148	336	2	s	s	PROPN
dpc-4148	336	3	,	,	PUNCT
dpc-4148	336	4	midwood	midwood	PROPN
dpc-4148	336	5	ks	ks	PROPN
dpc-4148	336	6	,	,	PUNCT
dpc-4148	336	7	varga	varga	PROPN
dpc-4148	336	8	j.	j.	PROPN
dpc-4148	336	9	tenascin	tenascin	PROPN
dpc-4148	336	10	-	-	PUNCT
dpc-4148	336	11	c	c	NOUN
dpc-4148	336	12	in	in	ADP
dpc-4148	336	13	fibrosis	fibrosis	NOUN
dpc-4148	336	14	in	in	ADP
dpc-4148	336	15	multiple	multiple	ADJ
dpc-4148	336	16	organs	organ	NOUN
dpc-4148	336	17	:	:	PUNCT
dpc-4148	336	18	translational	translational	ADJ
dpc-4148	336	19	implications	implication	NOUN
dpc-4148	336	20	.	.	PUNCT
dpc-4148	337	1	semin	semin	PROPN
dpc-4148	337	2	cell	cell	PROPN
dpc-4148	337	3	dev	dev	PROPN
dpc-4148	337	4	biol	biol	PROPN
dpc-4148	337	5	.	.	PUNCT
dpc-4148	338	1	2022;128:130	2022;128:130	NUM
dpc-4148	338	2	-	-	SYM
dpc-4148	338	3	136	136	NUM
dpc-4148	338	4	.	.	PUNCT
dpc-4148	339	1	doi	doi	NOUN
dpc-4148	339	2	:	:	PUNCT
dpc-4148	339	3	10.1016	10.1016	NUM
dpc-4148	339	4	/	/	SYM
dpc-4148	339	5	j.semcdb.2022.03.019	j.semcdb.2022.03.019	PROPN
dpc-4148	339	6	.	.	PUNCT
dpc-4148	340	1	variant	variant	NOUN
dpc-4148	340	2	of	of	ADP
dpc-4148	340	3	the	the	DET
dpc-4148	340	4	tnfaip3	tnfaip3	NOUN
dpc-4148	340	5	locus	locus	NOUN
dpc-4148	340	6	as	as	ADP
dpc-4148	340	7	a	a	DET
dpc-4148	340	8	risk	risk	NOUN
dpc-4148	340	9	factor	factor	NOUN
dpc-4148	340	10	for	for	ADP
dpc-4148	340	11	polyautoimmunity	polyautoimmunity	NOUN
dpc-4148	340	12	.	.	PUNCT
dpc-4148	341	1	arthritis	arthritis	NOUN
dpc-4148	341	2	rheum	rheum	NOUN
dpc-4148	341	3	.	.	PUNCT
dpc-4148	342	1	2012;64(8):2746	2012;64(8):2746	NUM
dpc-4148	342	2	–	–	PUNCT
dpc-4148	342	3	2752	2752	NUM
dpc-4148	342	4	.	.	PUNCT
dpc-4148	343	1	doi	doi	NOUN
dpc-4148	343	2	:	:	PUNCT
dpc-4148	343	3	10.1002/	10.1002/	NUM
dpc-4148	343	4	art.34490	art.34490	PROPN
dpc-4148	343	5	.	.	PROPN
dpc-4148	343	6	25	25	NUM
dpc-4148	343	7	.	.	PUNCT
dpc-4148	344	1	bossini	bossini	PROPN
dpc-4148	344	2	-	-	PUNCT
dpc-4148	344	3	castillo	castillo	PROPN
dpc-4148	344	4	l	l	PROPN
dpc-4148	344	5	,	,	PUNCT
dpc-4148	344	6	martin	martin	PROPN
dpc-4148	344	7	je	je	PROPN
dpc-4148	344	8	,	,	PUNCT
dpc-4148	344	9	broen	broen	PROPN
dpc-4148	344	10	j	j	PROPN
dpc-4148	344	11	,	,	PUNCT
dpc-4148	344	12	et	et	PROPN
dpc-4148	344	13	al	al	PROPN
dpc-4148	344	14	.	.	PUNCT
dpc-4148	344	15	confirmation	confirmation	NOUN
dpc-4148	344	16	of	of	ADP
dpc-4148	344	17	tnip1	tnip1	NOUN
dpc-4148	344	18	but	but	CCONJ
dpc-4148	344	19	not	not	PART
dpc-4148	344	20	rhob	rhob	VERB
dpc-4148	344	21	and	and	CCONJ
dpc-4148	344	22	psors1c1	psors1c1	NOUN
dpc-4148	344	23	as	as	ADP
dpc-4148	344	24	systemic	systemic	ADJ
dpc-4148	344	25	sclerosis	sclerosis	NOUN
dpc-4148	344	26	risk	risk	NOUN
dpc-4148	344	27	factors	factor	NOUN
dpc-4148	344	28	in	in	ADP
dpc-4148	344	29	a	a	DET
dpc-4148	344	30	large	large	ADJ
dpc-4148	344	31	independent	independent	ADJ
dpc-4148	344	32	replication	replication	NOUN
dpc-4148	344	33	study	study	NOUN
dpc-4148	344	34	.	.	PUNCT
dpc-4148	345	1	ann	ann	PROPN
dpc-4148	345	2	rheum	rheum	PROPN
dpc-4148	345	3	dis	dis	PROPN
dpc-4148	345	4	.	.	PUNCT
dpc-4148	346	1	2013;72(4):602–607	2013;72(4):602–607	NUM
dpc-4148	346	2	.	.	PUNCT
dpc-4148	347	1	doi	doi	NOUN
dpc-4148	347	2	:	:	PUNCT
dpc-4148	347	3	10.1136	10.1136	NUM
dpc-4148	347	4	/	/	SYM
dpc-4148	347	5	annrheumdis-2012	annrheumdis-2012	NOUN
dpc-4148	347	6	-	-	PUNCT
dpc-4148	347	7	201888	201888	NUM
dpc-4148	347	8	.	.	PUNCT
dpc-4148	348	1	26	26	NUM
dpc-4148	348	2	.	.	PUNCT
dpc-4148	349	1	allanore	allanore	PROPN
dpc-4148	349	2	y	y	PROPN
dpc-4148	349	3	,	,	PUNCT
dpc-4148	349	4	saad	saad	PROPN
dpc-4148	349	5	m	m	PROPN
dpc-4148	349	6	,	,	PUNCT
dpc-4148	349	7	dieude	dieude	VERB
dpc-4148	349	8	p	p	PRON
dpc-4148	349	9	,	,	PUNCT
dpc-4148	349	10	et	et	PROPN
dpc-4148	349	11	al	al	PROPN
dpc-4148	349	12	.	.	PUNCT
dpc-4148	349	13	genome	genome	NOUN
dpc-4148	349	14	-	-	PUNCT
dpc-4148	349	15	wide	wide	ADJ
dpc-4148	349	16	scan	scan	NOUN
dpc-4148	349	17	identifies	identify	VERB
dpc-4148	349	18	tnip1	tnip1	PROPN
dpc-4148	349	19	,	,	PUNCT
dpc-4148	349	20	psors1c1	psors1c1	NOUN
dpc-4148	349	21	,	,	PUNCT
dpc-4148	349	22	and	and	CCONJ
dpc-4148	349	23	rhob	rhob	VERB
dpc-4148	349	24	as	as	ADP
dpc-4148	349	25	novel	novel	ADJ
dpc-4148	349	26	risk	risk	NOUN
dpc-4148	349	27	loci	loci	NOUN
dpc-4148	349	28	for	for	ADP
dpc-4148	349	29	systemic	systemic	ADJ
dpc-4148	349	30	sclerosis	sclerosis	NOUN
dpc-4148	349	31	.	.	PUNCT
dpc-4148	350	1	plos	plos	PROPN
dpc-4148	350	2	genet	genet	PROPN
dpc-4148	350	3	.	.	PUNCT
dpc-4148	351	1	2011;7(7	2011;7(7	NUM
dpc-4148	351	2	):	):	PUNCT
dpc-4148	351	3	e1002091	e1002091	ADJ
dpc-4148	351	4	.	.	PUNCT
dpc-4148	351	5	doi	doi	NOUN
dpc-4148	351	6	:	:	PUNCT
dpc-4148	351	7	10.1371	10.1371	NUM
dpc-4148	351	8	/journal.pgen.1002091	/journal.pgen.1002091	SYM
dpc-4148	351	9	.	.	PROPN
dpc-4148	352	1	27	27	NUM
dpc-4148	352	2	.	.	X
dpc-4148	352	3	fang	fang	PROPN
dpc-4148	352	4	f	f	PROPN
dpc-4148	352	5	,	,	PUNCT
dpc-4148	352	6	ooka	ooka	ADJ
dpc-4148	352	7	k	k	PROPN
dpc-4148	352	8	,	,	PUNCT
dpc-4148	352	9	sun	sun	PROPN
dpc-4148	352	10	x	x	AUX
dpc-4148	352	11	,	,	PUNCT
dpc-4148	352	12	et	et	PROPN
dpc-4148	352	13	al	al	PROPN
dpc-4148	352	14	.	.	PUNCT
dpc-4148	353	1	a	a	DET
dpc-4148	353	2	synthetic	synthetic	ADJ
dpc-4148	353	3	tlr3	tlr3	NOUN
dpc-4148	353	4	ligand	ligand	VERB
dpc-4148	353	5	mitigates	mitigate	VERB
dpc-4148	353	6	profibrotic	profibrotic	ADJ
dpc-4148	353	7	fibroblast	fibroblast	ADJ
dpc-4148	353	8	responses	response	NOUN
dpc-4148	353	9	by	by	ADP
dpc-4148	353	10	inducing	induce	VERB
dpc-4148	353	11	autocrine	autocrine	NOUN
dpc-4148	353	12	ifn	ifn	NOUN
dpc-4148	353	13	signaling	signal	VERB
dpc-4148	353	14	.	.	PUNCT
dpc-4148	354	1	j	j	PROPN
dpc-4148	354	2	immunol	immunol	NOUN
dpc-4148	354	3	.	.	PUNCT
dpc-4148	355	1	2013;191(6):2956–2966	2013;191(6):2956–2966	NUM
dpc-4148	355	2	.	.	PUNCT
dpc-4148	355	3	doi	doi	NOUN
dpc-4148	355	4	:	:	PUNCT
dpc-4148	355	5	10.4049	10.4049	NUM
dpc-4148	355	6	/jimmunol.1300376	/jimmunol.1300376	PROPN
dpc-4148	355	7	.	.	PUNCT
dpc-4148	356	1	28	28	NUM
dpc-4148	356	2	.	.	PUNCT
dpc-4148	357	1	farina	farina	PROPN
dpc-4148	357	2	ga	ga	PROPN
dpc-4148	357	3	,	,	PUNCT
dpc-4148	357	4	york	york	PROPN
dpc-4148	357	5	mr	mr	PROPN
dpc-4148	357	6	,	,	PUNCT
dpc-4148	357	7	di	di	PROPN
dpc-4148	357	8	marzio	marzio	NOUN
dpc-4148	357	9	m	m	PROPN
dpc-4148	357	10	,	,	PUNCT
dpc-4148	357	11	et	et	PROPN
dpc-4148	357	12	al	al	PROPN
dpc-4148	357	13	.	.	PUNCT
dpc-4148	358	1	poly(i	poly(i	NOUN
dpc-4148	358	2	:	:	PUNCT
dpc-4148	358	3	c	c	X
dpc-4148	358	4	)	)	PUNCT
dpc-4148	358	5	drives	drive	VERB
dpc-4148	358	6	type	type	NOUN
dpc-4148	359	1	i	i	PRON
dpc-4148	359	2	ifnand	ifnand	NOUN
dpc-4148	359	3	tgfbeta	tgfbeta	PROPN
dpc-4148	359	4	mediated	mediate	VERB
dpc-4148	359	5	inflammation	inflammation	NOUN
dpc-4148	359	6	and	and	CCONJ
dpc-4148	359	7	dermal	dermal	ADJ
dpc-4148	359	8	fibrosis	fibrosis	NOUN
dpc-4148	359	9	simulating	simulate	VERB
dpc-4148	359	10	altered	alter	VERB
dpc-4148	359	11	gene	gene	NOUN
dpc-4148	359	12	expression	expression	NOUN
dpc-4148	359	13	in	in	ADP
dpc-4148	359	14	systemic	systemic	ADJ
dpc-4148	359	15	sclerosis	sclerosis	NOUN
dpc-4148	359	16	.	.	PUNCT
dpc-4148	360	1	j	j	PROPN
dpc-4148	360	2	investig	investig	NOUN
dpc-4148	360	3	dermatol	dermatol	NOUN
dpc-4148	360	4	.	.	PUNCT
dpc-4148	361	1	2010;130(11):2583–2593	2010;130(11):2583–2593	NUM
dpc-4148	361	2	.	.	X
dpc-4148	361	3	doi	doi	NOUN
dpc-4148	361	4	:	:	PUNCT
dpc-4148	361	5	10.1038	10.1038	NUM
dpc-4148	361	6	/jid.2010.200	/jid.2010.200	X
dpc-4148	361	7	.	.	PROPN
dpc-4148	362	1	29	29	NUM
dpc-4148	362	2	.	.	PUNCT
dpc-4148	363	1	bhattacharyya	bhattacharyya	PROPN
dpc-4148	363	2	s	s	PROPN
dpc-4148	363	3	,	,	PUNCT
dpc-4148	363	4	wang	wang	PROPN
dpc-4148	363	5	w	w	PROPN
dpc-4148	363	6	,	,	PUNCT
dpc-4148	363	7	morales	morales	PROPN
dpc-4148	363	8	-	-	PUNCT
dpc-4148	363	9	nebreda	nebreda	PROPN
dpc-4148	363	10	l	l	PROPN
dpc-4148	363	11	et	et	PROPN
dpc-4148	363	12	al	al	PROPN
dpc-4148	363	13	.	.	PROPN
dpc-4148	363	14	tenascin	tenascin	PROPN
dpc-4148	363	15	-	-	PUNCT
dpc-4148	363	16	c	c	NOUN
dpc-4148	363	17	drives	drive	VERB
dpc-4148	363	18	persistence	persistence	NOUN
dpc-4148	363	19	of	of	ADP
dpc-4148	363	20	organ	organ	NOUN
dpc-4148	363	21	fibrosis	fibrosis	NOUN
dpc-4148	363	22	.	.	PUNCT
dpc-4148	364	1	nat	nat	PROPN
dpc-4148	364	2	commun	commun	PROPN
dpc-4148	364	3	.	.	PROPN
dpc-4148	365	1	2016	2016	NUM
dpc-4148	365	2	;	;	PUNCT
dpc-4148	366	1	7:11703	7:11703	X
dpc-4148	366	2	.	.	X
dpc-4148	366	3	doi	doi	NOUN
dpc-4148	366	4	:	:	PUNCT
dpc-4148	366	5	10.1038	10.1038	NUM
dpc-4148	366	6	/	/	SYM
dpc-4148	366	7	ncomms11703	ncomms11703	PROPN
dpc-4148	366	8	30	30	NUM
dpc-4148	366	9	.	.	PUNCT
dpc-4148	366	10	frasca	frasca	PROPN
dpc-4148	367	1	l	l	PROPN
dpc-4148	367	2	,	,	PUNCT
dpc-4148	367	3	lande	lande	PROPN
dpc-4148	367	4	r.	r.	PROPN
dpc-4148	367	5	toll	toll	NOUN
dpc-4148	367	6	-	-	PUNCT
dpc-4148	367	7	like	like	ADJ
dpc-4148	367	8	receptors	receptor	NOUN
dpc-4148	367	9	in	in	ADP
dpc-4148	367	10	mediating	mediate	VERB
dpc-4148	367	11	pathogenesis	pathogenesis	NOUN
dpc-4148	367	12	in	in	ADP
dpc-4148	367	13	systemic	systemic	ADJ
dpc-4148	367	14	sclerosis	sclerosis	NOUN
dpc-4148	367	15	.	.	PUNCT
dpc-4148	368	1	clin	clin	PROPN
dpc-4148	368	2	exp	exp	NOUN
dpc-4148	368	3	immunol	immunol	NOUN
dpc-4148	368	4	.	.	PUNCT
dpc-4148	369	1	2020;201(1):14	2020;201(1):14	NUM
dpc-4148	369	2	-	-	SYM
dpc-4148	369	3	24	24	NUM
dpc-4148	369	4	.	.	PUNCT
dpc-4148	370	1	doi	doi	NOUN
dpc-4148	370	2	:	:	PUNCT
dpc-4148	370	3	10.1111	10.1111	NUM
dpc-4148	370	4	/	/	SYM
dpc-4148	370	5	cei.13426	cei.13426	PROPN
dpc-4148	370	6	.	.	NOUN
dpc-4148	371	1	31	31	NUM
dpc-4148	371	2	.	.	PUNCT
dpc-4148	372	1	o’reilly	o’reilly	PROPN
dpc-4148	372	2	s.	s.	PROPN
dpc-4148	372	3	toll	toll	NOUN
dpc-4148	372	4	like	like	ADP
dpc-4148	372	5	receptors	receptor	NOUN
dpc-4148	372	6	in	in	ADP
dpc-4148	372	7	systemic	systemic	ADJ
dpc-4148	372	8	sclerosis	sclerosis	NOUN
dpc-4148	372	9	:	:	PUNCT
dpc-4148	372	10	an	an	DET
dpc-4148	372	11	emerging	emerge	VERB
dpc-4148	372	12	target	target	NOUN
dpc-4148	372	13	.	.	PUNCT
dpc-4148	373	1	immunol	immunol	PROPN
dpc-4148	373	2	lett	lett	PROPN
dpc-4148	373	3	.	.	PUNCT
dpc-4148	374	1	2018;195:2	2018;195:2	NUM
dpc-4148	374	2	-	-	SYM
dpc-4148	374	3	8	8	NUM
dpc-4148	374	4	.	.	PUNCT
dpc-4148	375	1	doi	doi	NOUN
dpc-4148	375	2	:	:	PUNCT
dpc-4148	375	3	10.1016	10.1016	NUM
dpc-4148	375	4	/	/	SYM
dpc-4148	375	5	j.imlet	j.imlet	ADV
dpc-4148	375	6	.2017.09.001	.2017.09.001	PROPN
dpc-4148	375	7	.	.	PUNCT