id sid tid token lemma pos dpc-4458 1 1 dermatology dermatology NOUN dpc-4458 1 2 : : PUNCT dpc-4458 1 3 practical practical ADJ dpc-4458 1 4 and and CCONJ dpc-4458 1 5 conceptual conceptual ADJ dpc-4458 1 6 original original ADJ dpc-4458 1 7 article article NOUN dpc-4458 1 8 | | ADV dpc-4458 1 9 dermatol dermatol ADJ dpc-4458 1 10 pract pract NOUN dpc-4458 1 11 concept concept NOUN dpc-4458 1 12 . . PUNCT dpc-4458 2 1 2025;15(1):4458 2025;15(1):4458 NUM dpc-4458 2 2 1 1 NUM dpc-4458 2 3 causal causal NOUN dpc-4458 2 4 relationship relationship NOUN dpc-4458 2 5 between between ADP dpc-4458 2 6 psoriasis psoriasis NOUN dpc-4458 2 7 and and CCONJ dpc-4458 2 8 bullous bullous ADJ dpc-4458 2 9 pemphigoid pemphigoid NOUN dpc-4458 2 10 : : PUNCT dpc-4458 2 11 a a DET dpc-4458 2 12 mendelian mendelian ADJ dpc-4458 2 13 randomization randomization NOUN dpc-4458 2 14 analysis analysis NOUN dpc-4458 2 15 xiaoxue xiaoxue PROPN dpc-4458 2 16 wang1 wang1 PROPN dpc-4458 2 17 , , PUNCT dpc-4458 2 18 zexin zexin PROPN dpc-4458 2 19 zhu2 zhu2 PROPN dpc-4458 2 20 1 1 NUM dpc-4458 2 21 department department NOUN dpc-4458 2 22 of of ADP dpc-4458 2 23 dermatology dermatology NOUN dpc-4458 2 24 , , PUNCT dpc-4458 2 25 the the DET dpc-4458 2 26 second second ADJ dpc-4458 2 27 affiliated affiliated ADJ dpc-4458 2 28 hospital hospital NOUN dpc-4458 2 29 of of ADP dpc-4458 2 30 xi’an xi’an PROPN dpc-4458 2 31 jiaotong jiaotong PROPN dpc-4458 2 32 university university PROPN dpc-4458 2 33 , , PUNCT dpc-4458 2 34 xi’an xi’an PROPN dpc-4458 2 35 , , PUNCT dpc-4458 2 36 china china PROPN dpc-4458 2 37 2 2 NUM dpc-4458 2 38 department department NOUN dpc-4458 2 39 of of ADP dpc-4458 2 40 surgical surgical ADJ dpc-4458 2 41 oncology oncology NOUN dpc-4458 2 42 , , PUNCT dpc-4458 2 43 the the DET dpc-4458 2 44 comprehensive comprehensive ADJ dpc-4458 2 45 breast breast NOUN dpc-4458 2 46 care care NOUN dpc-4458 2 47 center center NOUN dpc-4458 2 48 , , PUNCT dpc-4458 2 49 the the DET dpc-4458 2 50 second second ADJ dpc-4458 2 51 affiliated affiliated ADJ dpc-4458 2 52 hospital hospital NOUN dpc-4458 2 53 of of ADP dpc-4458 2 54 xi’an xi’an PROPN dpc-4458 2 55 jiaotong jiaotong PROPN dpc-4458 2 56 university university PROPN dpc-4458 2 57 , , PUNCT dpc-4458 2 58 xi’an xi’an PROPN dpc-4458 2 59 , , PUNCT dpc-4458 2 60 china china PROPN dpc-4458 2 61 key key ADJ dpc-4458 2 62 words word NOUN dpc-4458 2 63 : : PUNCT dpc-4458 2 64 psoriasis psoriasis NOUN dpc-4458 2 65 , , PUNCT dpc-4458 2 66 bullous bullous ADJ dpc-4458 2 67 pemphigoid pemphigoid NOUN dpc-4458 2 68 , , PUNCT dpc-4458 2 69 mendelian mendelian ADJ dpc-4458 2 70 randomization randomization NOUN dpc-4458 2 71 , , PUNCT dpc-4458 2 72 causal causal NOUN dpc-4458 2 73 relationship relationship NOUN dpc-4458 2 74 citation citation NOUN dpc-4458 2 75 : : PUNCT dpc-4458 2 76 wang wang PROPN dpc-4458 2 77 x x PROPN dpc-4458 2 78 , , PUNCT dpc-4458 2 79 zhu zhu PROPN dpc-4458 2 80 z. z. PROPN dpc-4458 2 81 causal causal PROPN dpc-4458 2 82 relationship relationship NOUN dpc-4458 2 83 between between ADP dpc-4458 2 84 psoriasis psoriasis NOUN dpc-4458 2 85 and and CCONJ dpc-4458 2 86 bullous bullous ADJ dpc-4458 2 87 pemphigoid pemphigoid NOUN dpc-4458 2 88 : : PUNCT dpc-4458 2 89 a a DET dpc-4458 2 90 mendelian mendelian ADJ dpc-4458 2 91 randomization randomization NOUN dpc-4458 2 92 analysis analysis NOUN dpc-4458 2 93 . . PUNCT dpc-4458 3 1 dermatol dermatol NOUN dpc-4458 3 2 pract pract PROPN dpc-4458 3 3 concept concept NOUN dpc-4458 3 4 . . PUNCT dpc-4458 4 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 4 2 . . PUNCT dpc-4458 5 1 doi doi NOUN dpc-4458 5 2 : : PUNCT dpc-4458 5 3 https://doi.org/10.5826/dpc.1501a4458 https://doi.org/10.5826/dpc.1501a4458 PROPN dpc-4458 5 4 accepted accept VERB dpc-4458 5 5 : : PUNCT dpc-4458 5 6 august august PROPN dpc-4458 5 7 12 12 NUM dpc-4458 5 8 , , PUNCT dpc-4458 5 9 2024 2024 NUM dpc-4458 5 10 ; ; PUNCT dpc-4458 5 11 published publish VERB dpc-4458 5 12 : : PUNCT dpc-4458 5 13 january january PROPN dpc-4458 5 14 2025 2025 NUM dpc-4458 5 15 copyright copyright NOUN dpc-4458 5 16 : : PUNCT dpc-4458 6 1 © © PROPN dpc-4458 6 2 2024 2024 NUM dpc-4458 6 3 wang wang PROPN dpc-4458 6 4 et et PROPN dpc-4458 6 5 al al PROPN dpc-4458 6 6 . . PUNCT dpc-4458 7 1 this this PRON dpc-4458 7 2 is be AUX dpc-4458 7 3 an an DET dpc-4458 7 4 open open ADJ dpc-4458 7 5 - - PUNCT dpc-4458 7 6 access access NOUN dpc-4458 7 7 article article NOUN dpc-4458 7 8 distributed distribute VERB dpc-4458 7 9 under under ADP dpc-4458 7 10 the the DET dpc-4458 7 11 terms term NOUN dpc-4458 7 12 of of ADP dpc-4458 7 13 the the DET dpc-4458 7 14 creative creative ADJ dpc-4458 7 15 commons common NOUN dpc-4458 7 16 attributionnoncommercial attributionnoncommercial ADJ dpc-4458 7 17 license license NOUN dpc-4458 7 18 ( ( PUNCT dpc-4458 7 19 by by ADP dpc-4458 7 20 - - PUNCT dpc-4458 7 21 nc-4.0 nc-4.0 NOUN dpc-4458 7 22 ) ) PUNCT dpc-4458 7 23 , , PUNCT dpc-4458 7 24 https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ PROPN dpc-4458 7 25 , , PUNCT dpc-4458 7 26 which which PRON dpc-4458 7 27 permits permit VERB dpc-4458 7 28 unrestricted unrestricted ADJ dpc-4458 7 29 noncommercial noncommercial ADJ dpc-4458 7 30 use use NOUN dpc-4458 7 31 , , PUNCT dpc-4458 7 32 distribution distribution NOUN dpc-4458 7 33 , , PUNCT dpc-4458 7 34 and and CCONJ dpc-4458 7 35 reproduction reproduction NOUN dpc-4458 7 36 in in ADP dpc-4458 7 37 any any DET dpc-4458 7 38 medium medium NOUN dpc-4458 7 39 , , PUNCT dpc-4458 7 40 provided provide VERB dpc-4458 7 41 the the DET dpc-4458 7 42 original original ADJ dpc-4458 7 43 authors author NOUN dpc-4458 7 44 and and CCONJ dpc-4458 7 45 source source NOUN dpc-4458 7 46 are be AUX dpc-4458 7 47 credited credit VERB dpc-4458 7 48 . . PUNCT dpc-4458 8 1 funding funding NOUN dpc-4458 8 2 : : PUNCT dpc-4458 8 3 this this DET dpc-4458 8 4 work work NOUN dpc-4458 8 5 was be AUX dpc-4458 8 6 supported support VERB dpc-4458 8 7 by by ADP dpc-4458 8 8 the the DET dpc-4458 8 9 natural natural ADJ dpc-4458 8 10 science science PROPN dpc-4458 8 11 foundation foundation PROPN dpc-4458 8 12 of of ADP dpc-4458 8 13 china china PROPN dpc-4458 8 14 ( ( PUNCT dpc-4458 8 15 grant grant PROPN dpc-4458 8 16 number number NOUN dpc-4458 8 17 : : PUNCT dpc-4458 8 18 82404921 82404921 NUM dpc-4458 8 19 ) ) PUNCT dpc-4458 8 20 . . PUNCT dpc-4458 9 1 competing compete VERB dpc-4458 9 2 interests interest NOUN dpc-4458 9 3 : : PUNCT dpc-4458 9 4 none none NOUN dpc-4458 9 5 . . PUNCT dpc-4458 10 1 authorship authorship NOUN dpc-4458 10 2 : : PUNCT dpc-4458 10 3 all all DET dpc-4458 10 4 authors author NOUN dpc-4458 10 5 have have AUX dpc-4458 10 6 contributed contribute VERB dpc-4458 10 7 significantly significantly ADV dpc-4458 10 8 to to ADP dpc-4458 10 9 this this DET dpc-4458 10 10 publication publication NOUN dpc-4458 10 11 . . PUNCT dpc-4458 11 1 corresponding correspond VERB dpc-4458 11 2 author author NOUN dpc-4458 11 3 : : PUNCT dpc-4458 11 4 zexin zexin PROPN dpc-4458 11 5 zhu zhu PROPN dpc-4458 11 6 , , PUNCT dpc-4458 11 7 department department NOUN dpc-4458 11 8 of of ADP dpc-4458 11 9 surgical surgical ADJ dpc-4458 11 10 oncology oncology NOUN dpc-4458 11 11 , , PUNCT dpc-4458 11 12 the the DET dpc-4458 11 13 comprehensive comprehensive ADJ dpc-4458 11 14 breast breast NOUN dpc-4458 11 15 care care NOUN dpc-4458 11 16 center center NOUN dpc-4458 11 17 , , PUNCT dpc-4458 11 18 the the DET dpc-4458 11 19 second second ADJ dpc-4458 11 20 affiliated affiliated ADJ dpc-4458 11 21 hospital hospital NOUN dpc-4458 11 22 of of ADP dpc-4458 11 23 xi’an xi’an PROPN dpc-4458 11 24 jiaotong jiaotong PROPN dpc-4458 11 25 university university PROPN dpc-4458 11 26 , , PUNCT dpc-4458 11 27 xi’an xi’an PROPN dpc-4458 11 28 , , PUNCT dpc-4458 11 29 china china PROPN dpc-4458 11 30 . . PUNCT dpc-4458 12 1 email email NOUN dpc-4458 12 2 : : PUNCT dpc-4458 12 3 zhuzexinmd@163.com zhuzexinmd@163.com X dpc-4458 12 4 introduction introduction NOUN dpc-4458 12 5 : : PUNCT dpc-4458 12 6 psoriasis psoriasis NOUN dpc-4458 12 7 and and CCONJ dpc-4458 12 8 bullous bullous ADJ dpc-4458 12 9 pemphigoid pemphigoid NOUN dpc-4458 12 10     SPACE dpc-4458 12 11 ( ( PUNCT dpc-4458 12 12 bp bp PROPN dpc-4458 12 13 ) ) PUNCT dpc-4458 12 14     SPACE dpc-4458 12 15 are be AUX dpc-4458 12 16 the the DET dpc-4458 12 17 two two NUM dpc-4458 12 18 major major ADJ dpc-4458 12 19 types type NOUN dpc-4458 12 20 of of ADP dpc-4458 12 21 immune immune ADJ dpc-4458 12 22 mediated mediate VERB dpc-4458 12 23     SPACE dpc-4458 12 24 inflammatory inflammatory ADJ dpc-4458 12 25     SPACE dpc-4458 12 26 skin skin NOUN dpc-4458 12 27 diseases disease NOUN dpc-4458 12 28 . . PUNCT dpc-4458 13 1 studies study NOUN dpc-4458 13 2 have have AUX dpc-4458 13 3 reported report VERB dpc-4458 13 4 the the DET dpc-4458 13 5     SPACE dpc-4458 13 6 association association NOUN dpc-4458 13 7 between between ADP dpc-4458 13 8 psoriasis psoriasis NOUN dpc-4458 13 9 and and CCONJ dpc-4458 13 10 bp bp PROPN dpc-4458 13 11 ; ; PUNCT dpc-4458 13 12     SPACE dpc-4458 13 13 however however ADV dpc-4458 13 14 , , PUNCT dpc-4458 13 15     SPACE dpc-4458 13 16 no no DET dpc-4458 13 17 studies study NOUN dpc-4458 13 18 have have AUX dpc-4458 13 19 reported report VERB dpc-4458 13 20 whether whether SCONJ dpc-4458 13 21 a a DET dpc-4458 13 22 causal causal ADJ dpc-4458 13 23 relationship relationship NOUN dpc-4458 13 24 exists exist VERB dpc-4458 13 25 between between ADP dpc-4458 13 26 these these DET dpc-4458 13 27 two two NUM dpc-4458 13 28 skin skin NOUN dpc-4458 13 29 diseases disease NOUN dpc-4458 13 30 . . PUNCT dpc-4458 14 1 objectives objective NOUN dpc-4458 14 2 : : PUNCT dpc-4458 14 3 in in ADP dpc-4458 14 4 order order NOUN dpc-4458 14 5 to to PART dpc-4458 14 6 explore explore VERB dpc-4458 14 7 the the DET dpc-4458 14 8 causal causal ADJ dpc-4458 14 9 relationship relationship NOUN dpc-4458 14 10 between between ADP dpc-4458 14 11 psoriasis psoriasis NOUN dpc-4458 14 12 and and CCONJ dpc-4458 14 13 bp bp PROPN dpc-4458 14 14 , , PUNCT dpc-4458 14 15 we we PRON dpc-4458 14 16 performed perform VERB dpc-4458 14 17 a a DET dpc-4458 14 18 bidirectional bidirectional ADJ dpc-4458 14 19 two two NUM dpc-4458 14 20 - - PUNCT dpc-4458 14 21 sample sample NOUN dpc-4458 14 22 mendelian mendelian ADJ dpc-4458 14 23 randomization randomization NOUN dpc-4458 14 24 ( ( PUNCT dpc-4458 14 25 mr mr PROPN dpc-4458 14 26 ) ) PUNCT dpc-4458 14 27 study study NOUN dpc-4458 14 28 . . PUNCT dpc-4458 15 1 methods method NOUN dpc-4458 15 2 : : PUNCT dpc-4458 15 3 genome genome NOUN dpc-4458 15 4 - - PUNCT dpc-4458 15 5 wide wide ADJ dpc-4458 15 6 association association NOUN dpc-4458 15 7 study study NOUN dpc-4458 15 8 ( ( PUNCT dpc-4458 15 9 gwas gwas PROPN dpc-4458 15 10 ) ) PUNCT dpc-4458 15 11 data datum NOUN dpc-4458 15 12 related relate VERB dpc-4458 15 13 to to ADP dpc-4458 15 14 psoriasis psoriasis NOUN dpc-4458 15 15     SPACE dpc-4458 15 16 and and CCONJ dpc-4458 15 17 bp bp PROPN dpc-4458 15 18 were be AUX dpc-4458 15 19 collected collect VERB dpc-4458 15 20 . . PUNCT dpc-4458 16 1 the the DET dpc-4458 16 2 inverse inverse NOUN dpc-4458 16 3 - - PUNCT dpc-4458 16 4 variance variance NOUN dpc-4458 16 5 weighted weight VERB dpc-4458 16 6 ( ( PUNCT dpc-4458 16 7 ivw ivw NOUN dpc-4458 16 8 ) ) PUNCT dpc-4458 16 9 method method NOUN dpc-4458 16 10 was be AUX dpc-4458 16 11 primarily primarily ADV dpc-4458 16 12 applied apply VERB dpc-4458 16 13 for for ADP dpc-4458 16 14 our our PRON dpc-4458 16 15 mr mr PROPN dpc-4458 16 16 analysis analysis NOUN dpc-4458 16 17 ; ; PUNCT dpc-4458 16 18 mr mr PROPN dpc-4458 16 19 - - PUNCT dpc-4458 16 20 egger egger NOUN dpc-4458 16 21 , , PUNCT dpc-4458 16 22 weighted weight VERB dpc-4458 16 23 median median ADJ dpc-4458 16 24 , , PUNCT dpc-4458 16 25 simple simple ADJ dpc-4458 16 26 mode mode NOUN dpc-4458 16 27 , , PUNCT dpc-4458 16 28 and and CCONJ dpc-4458 16 29 weighted weight VERB dpc-4458 16 30 mode mode NOUN dpc-4458 16 31 methods method NOUN dpc-4458 16 32 were be AUX dpc-4458 16 33 also also ADV dpc-4458 16 34     SPACE dpc-4458 16 35 used use VERB dpc-4458 16 36 . . PUNCT dpc-4458 17 1 heterogeneity heterogeneity NOUN dpc-4458 17 2 , , PUNCT dpc-4458 17 3 horizontal horizontal ADJ dpc-4458 17 4 pleiotropy pleiotropy NOUN dpc-4458 17 5 , , PUNCT dpc-4458 17 6 and and CCONJ dpc-4458 17 7 potential potential ADJ dpc-4458 17 8 outliers outlier NOUN dpc-4458 17 9 were be AUX dpc-4458 17 10 assessed assess VERB dpc-4458 17 11 for for ADP dpc-4458 17 12 the the DET dpc-4458 17 13 mr mr PROPN dpc-4458 17 14 analysis analysis NOUN dpc-4458 17 15 results result NOUN dpc-4458 17 16 . . PUNCT dpc-4458 18 1 results result NOUN dpc-4458 18 2 : : PUNCT dpc-4458 18 3 gwas gwas PROPN dpc-4458 18 4 data datum NOUN dpc-4458 18 5 for for ADP dpc-4458 18 6 psoriasis psoriasis NOUN dpc-4458 18 7 ( ( PUNCT dpc-4458 18 8 three three NUM dpc-4458 18 9 cohorts cohort NOUN dpc-4458 18 10 ) ) PUNCT dpc-4458 18 11 and and CCONJ dpc-4458 18 12 bp bp PROPN dpc-4458 18 13 ( ( PUNCT dpc-4458 18 14 one one NUM dpc-4458 18 15 cohort cohort NOUN dpc-4458 18 16 ) ) PUNCT dpc-4458 18 17 from from ADP dpc-4458 18 18 publicly publicly ADV dpc-4458 18 19 available available ADJ dpc-4458 18 20 trials trial NOUN dpc-4458 18 21 were be AUX dpc-4458 18 22 selected select VERB dpc-4458 18 23 . . PUNCT dpc-4458 19 1 our our PRON dpc-4458 19 2 mr mr PROPN dpc-4458 19 3 results result NOUN dpc-4458 19 4 showed show VERB dpc-4458 19 5 that that SCONJ dpc-4458 19 6 psoriasis psoriasis NOUN dpc-4458 19 7     SPACE dpc-4458 19 8 was be AUX dpc-4458 19 9     SPACE dpc-4458 19 10 causally causally ADV dpc-4458 19 11 associated associate VERB dpc-4458 19 12 with with ADP dpc-4458 19 13 bp bp PROPN dpc-4458 19 14 , , PUNCT dpc-4458 19 15 that that DET dpc-4458 19 16 psoriasis psoriasis NOUN dpc-4458 19 17 could could AUX dpc-4458 19 18 increase increase VERB dpc-4458 19 19 the the DET dpc-4458 19 20 risk risk NOUN dpc-4458 19 21 of of ADP dpc-4458 19 22 bp bp PROPN dpc-4458 19 23 , , PUNCT dpc-4458 19 24 and and CCONJ dpc-4458 19 25 that that PRON dpc-4458 19 26 reversed reverse VERB dpc-4458 19 27 mr mr PROPN dpc-4458 19 28 showed show VERB dpc-4458 19 29 bp bp PROPN dpc-4458 19 30 has have VERB dpc-4458 19 31 no no DET dpc-4458 19 32 causal causal ADJ dpc-4458 19 33 effect effect NOUN dpc-4458 19 34 on on ADP dpc-4458 19 35 psoriasis psoriasis NOUN dpc-4458 19 36 . . PUNCT dpc-4458 20 1 no no DET dpc-4458 20 2 heterogeneity heterogeneity NOUN dpc-4458 20 3 or or CCONJ dpc-4458 20 4 pleiotropy pleiotropy NOUN dpc-4458 20 5 was be AUX dpc-4458 20 6 detected detect VERB dpc-4458 20 7 . . PUNCT dpc-4458 20 8     SPACE dpc-4458 21 1 conclusion conclusion NOUN dpc-4458 21 2 : : PUNCT dpc-4458 21 3 these these DET dpc-4458 21 4 findings finding NOUN dpc-4458 21 5 provided provide VERB dpc-4458 21 6 new new ADJ dpc-4458 21 7 evidence evidence NOUN dpc-4458 21 8 of of ADP dpc-4458 21 9 the the DET dpc-4458 21 10 causal causal ADJ dpc-4458 21 11 relationship relationship NOUN dpc-4458 21 12 between between ADP dpc-4458 21 13 psoriasis psoriasis NOUN dpc-4458 21 14 and and CCONJ dpc-4458 21 15 bp bp PROPN dpc-4458 21 16 . . PUNCT dpc-4458 21 17     SPACE dpc-4458 22 1 our our PRON dpc-4458 22 2 mr mr PROPN dpc-4458 22 3     SPACE dpc-4458 22 4 suggested suggest VERB dpc-4458 22 5     SPACE dpc-4458 22 6 that that SCONJ dpc-4458 22 7 psoriasis psoriasis NOUN dpc-4458 22 8 is be AUX dpc-4458 22 9 potentially potentially ADV dpc-4458 22 10 causal causal ADJ dpc-4458 22 11 to to AUX dpc-4458 22 12 bp bp PROPN dpc-4458 22 13 , , PUNCT dpc-4458 22 14 which which PRON dpc-4458 22 15 helps help VERB dpc-4458 22 16 us we PRON dpc-4458 22 17 to to PART dpc-4458 22 18 improve improve VERB dpc-4458 22 19 the the DET dpc-4458 22 20 treatment treatment NOUN dpc-4458 22 21 strategy strategy NOUN dpc-4458 22 22 for for ADP dpc-4458 22 23 patients patient NOUN dpc-4458 22 24 with with ADP dpc-4458 22 25 psoriasis psoriasis NOUN dpc-4458 22 26 . . PUNCT dpc-4458 23 1 the the DET dpc-4458 23 2 mechanism mechanism NOUN dpc-4458 23 3 remains remain VERB dpc-4458 23 4 open open ADJ dpc-4458 23 5 for for ADP dpc-4458 23 6 further further ADJ dpc-4458 23 7 investigation investigation NOUN dpc-4458 23 8 . . PUNCT dpc-4458 24 1 abstract abstract ADJ dpc-4458 24 2 2 2 NUM dpc-4458 24 3 original original ADJ dpc-4458 24 4 article article NOUN dpc-4458 24 5 | | ADV dpc-4458 24 6 dermatol dermatol ADJ dpc-4458 24 7 pract pract NOUN dpc-4458 24 8 concept concept NOUN dpc-4458 24 9 . . PUNCT dpc-4458 25 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 25 2 introduction introduction NOUN dpc-4458 25 3 psoriasis psoriasis NOUN dpc-4458 25 4 is be AUX dpc-4458 25 5 a a DET dpc-4458 25 6 common common ADJ dpc-4458 25 7 chronic chronic ADJ dpc-4458 25 8 inflammatory inflammatory ADJ dpc-4458 25 9 skin skin NOUN dpc-4458 25 10 disease disease NOUN dpc-4458 25 11 [ [ X dpc-4458 25 12 1 1 NUM dpc-4458 25 13 ] ] PUNCT dpc-4458 25 14 , , PUNCT dpc-4458 25 15 with with ADP dpc-4458 25 16     SPACE dpc-4458 25 17 a a DET dpc-4458 25 18 relatively relatively ADV dpc-4458 25 19 high high ADJ dpc-4458 25 20 incidence incidence NOUN dpc-4458 25 21 and and CCONJ dpc-4458 25 22 prevalence prevalence NOUN dpc-4458 25 23 worldwide worldwide ADV dpc-4458 25 24 . . PUNCT dpc-4458 26 1 accordingly accordingly ADV dpc-4458 26 2 , , PUNCT dpc-4458 26 3 psoriasis psoriasis NOUN dpc-4458 26 4 affects affect VERB dpc-4458 26 5 2%–3 2%–3 NOUN dpc-4458 26 6 % % NOUN dpc-4458 26 7 of of ADP dpc-4458 26 8 adults adult NOUN dpc-4458 26 9 in in ADP dpc-4458 26 10 the the DET dpc-4458 26 11 usa usa PROPN dpc-4458 26 12 and and CCONJ dpc-4458 26 13 europe europe PROPN dpc-4458 26 14 , , PUNCT dpc-4458 26 15 about about ADV dpc-4458 26 16 125 125 NUM dpc-4458 26 17 million million NUM dpc-4458 26 18 people people NOUN dpc-4458 26 19 globally globally ADV dpc-4458 26 20 [ [ X dpc-4458 26 21 2 2 NUM dpc-4458 26 22 , , PUNCT dpc-4458 26 23 3 3 NUM dpc-4458 26 24 ] ] PUNCT dpc-4458 26 25 . . PUNCT dpc-4458 27 1 studies study NOUN dpc-4458 27 2 have have AUX dpc-4458 27 3 reported report VERB dpc-4458 27 4 that that SCONJ dpc-4458 27 5 patients patient NOUN dpc-4458 27 6 with with ADP dpc-4458 27 7 severe severe ADJ dpc-4458 27 8 psoriasis psoriasis NOUN dpc-4458 27 9 have have VERB dpc-4458 27 10 a a DET dpc-4458 27 11 significantly significantly ADV dpc-4458 27 12 increased increase VERB dpc-4458 27 13 probability probability NOUN dpc-4458 27 14 of of ADP dpc-4458 27 15 loss loss NOUN dpc-4458 27 16 of of ADP dpc-4458 27 17 work work NOUN dpc-4458 27 18 , , PUNCT dpc-4458 27 19 more more ADJ dpc-4458 27 20 than than ADP dpc-4458 27 21 four four NUM dpc-4458 27 22 times time NOUN dpc-4458 27 23 so so ADV dpc-4458 27 24 , , PUNCT dpc-4458 27 25 which which PRON dpc-4458 27 26 gives give VERB dpc-4458 27 27 rise rise NOUN dpc-4458 27 28 to to ADP dpc-4458 27 29 a a DET dpc-4458 27 30 greater great ADJ dpc-4458 27 31 impact impact NOUN dpc-4458 27 32 on on ADP dpc-4458 27 33 quality quality NOUN dpc-4458 27 34 of of ADP dpc-4458 27 35 life life NOUN dpc-4458 27 36 [ [ X dpc-4458 27 37 4 4 NUM dpc-4458 27 38 ] ] PUNCT dpc-4458 27 39 . . PUNCT dpc-4458 28 1 pathologically pathologically ADV dpc-4458 28 2 , , PUNCT dpc-4458 28 3 the the DET dpc-4458 28 4 development development NOUN dpc-4458 28 5 of of ADP dpc-4458 28 6 psoriasis psoriasis NOUN dpc-4458 28 7 is be AUX dpc-4458 28 8 mainly mainly ADV dpc-4458 28 9 attributed attribute VERB dpc-4458 28 10 to to ADP dpc-4458 28 11 immune immune ADJ dpc-4458 28 12 dysfunction dysfunction NOUN dpc-4458 28 13 , , PUNCT dpc-4458 28 14 vascular vascular ADJ dpc-4458 28 15 injury injury NOUN dpc-4458 28 16 , , PUNCT dpc-4458 28 17 disturbance disturbance NOUN dpc-4458 28 18 of of ADP dpc-4458 28 19 signal signal ADJ dpc-4458 28 20 transduction transduction NOUN dpc-4458 28 21 pathway pathway NOUN dpc-4458 28 22 , , PUNCT dpc-4458 28 23 and and CCONJ dpc-4458 28 24 imbalance imbalance NOUN dpc-4458 28 25 of of ADP dpc-4458 28 26 psoriasis psoriasis NOUN dpc-4458 28 27 - - PUNCT dpc-4458 28 28 related relate VERB dpc-4458 28 29 gene gene NOUN dpc-4458 28 30 expression expression NOUN dpc-4458 28 31 . . PUNCT dpc-4458 29 1 the the DET dpc-4458 29 2 most most ADV dpc-4458 29 3 common common ADJ dpc-4458 29 4 clinical clinical ADJ dpc-4458 29 5 characteristic characteristic NOUN dpc-4458 29 6 in in ADP dpc-4458 29 7 psoriasis psoriasis NOUN dpc-4458 29 8 is be AUX dpc-4458 29 9 red red ADJ dpc-4458 29 10 or or CCONJ dpc-4458 29 11 pink pink ADJ dpc-4458 29 12 plaques plaque NOUN dpc-4458 29 13 covered cover VERB dpc-4458 29 14 by by ADP dpc-4458 29 15 silvery silvery NOUN dpc-4458 29 16 scales scale NOUN dpc-4458 29 17 . . PUNCT dpc-4458 30 1 emerging emerge VERB dpc-4458 30 2 studies study NOUN dpc-4458 30 3 have have AUX dpc-4458 30 4 gradually gradually ADV dpc-4458 30 5 illuminated illuminate VERB dpc-4458 30 6 the the DET dpc-4458 30 7 pathogenesis pathogenesis NOUN dpc-4458 30 8 of of ADP dpc-4458 30 9 psoriasis psoriasis NOUN dpc-4458 30 10 in in ADP dpc-4458 30 11 the the DET dpc-4458 30 12 past past ADJ dpc-4458 30 13 years year NOUN dpc-4458 30 14 . . PUNCT dpc-4458 31 1 meanwhile meanwhile ADV dpc-4458 31 2 , , PUNCT dpc-4458 31 3 the the DET dpc-4458 31 4 etiology etiology NOUN dpc-4458 31 5 of of ADP dpc-4458 31 6 psoriasis psoriasis NOUN dpc-4458 31 7 still still ADV dpc-4458 31 8 remains remain VERB dpc-4458 31 9 largely largely ADV dpc-4458 31 10 elusive elusive ADJ dpc-4458 31 11 . . PUNCT dpc-4458 32 1 a a DET dpc-4458 32 2 specific specific ADJ dpc-4458 32 3 aspect aspect NOUN dpc-4458 32 4 of of ADP dpc-4458 32 5 psoriasis psoriasis NOUN dpc-4458 32 6 progression progression NOUN dpc-4458 32 7 involves involve VERB dpc-4458 32 8 substantial substantial ADJ dpc-4458 32 9 psychological psychological ADJ dpc-4458 32 10 disability disability NOUN dpc-4458 32 11 , , PUNCT dpc-4458 32 12 with with ADP dpc-4458 32 13 up up ADP dpc-4458 32 14 to to PART dpc-4458 32 15 20 20 NUM dpc-4458 32 16 % % NOUN dpc-4458 32 17 of of ADP dpc-4458 32 18 those those DET dpc-4458 32 19 affected affected ADJ dpc-4458 32 20 reporting reporting NOUN dpc-4458 32 21 symptoms symptom NOUN dpc-4458 32 22 of of ADP dpc-4458 32 23 depression depression NOUN dpc-4458 32 24 [ [ X dpc-4458 32 25 5 5 NUM dpc-4458 32 26 ] ] PUNCT dpc-4458 32 27 . . PUNCT dpc-4458 33 1 treatment treatment NOUN dpc-4458 33 2 strategies strategy NOUN dpc-4458 33 3 for for ADP dpc-4458 33 4 patients patient NOUN dpc-4458 33 5 with with ADP dpc-4458 33 6 psoriasis psoriasis NOUN dpc-4458 33 7 include include VERB dpc-4458 33 8 topical topical ADJ dpc-4458 33 9 therapies therapy NOUN dpc-4458 33 10 , , PUNCT dpc-4458 33 11 oral oral ADJ dpc-4458 33 12 medications medication NOUN dpc-4458 33 13 , , PUNCT dpc-4458 33 14 biologic biologic NOUN dpc-4458 33 15 agents agent NOUN dpc-4458 33 16 , , PUNCT dpc-4458 33 17 and and CCONJ dpc-4458 33 18 phototherapy phototherapy NOUN dpc-4458 33 19 . . PUNCT dpc-4458 34 1 for for ADP dpc-4458 34 2 patients patient NOUN dpc-4458 34 3 with with ADP dpc-4458 34 4 severe severe ADJ dpc-4458 34 5 disease disease NOUN dpc-4458 34 6 , , PUNCT dpc-4458 34 7 which which PRON dpc-4458 34 8 can can AUX dpc-4458 34 9 not not PART dpc-4458 34 10 be be AUX dpc-4458 34 11 controlled control VERB dpc-4458 34 12 with with ADP dpc-4458 34 13 the the DET dpc-4458 34 14 fundamental fundamental ADJ dpc-4458 34 15 use use NOUN dpc-4458 34 16 of of ADP dpc-4458 34 17 topical topical ADJ dpc-4458 34 18 therapies therapy NOUN dpc-4458 34 19 ( ( PUNCT dpc-4458 34 20 e.g. e.g. ADV dpc-4458 34 21 corticosteroids corticosteroid NOUN dpc-4458 34 22 ) ) PUNCT dpc-4458 34 23 , , PUNCT dpc-4458 34 24 systemic systemic ADJ dpc-4458 34 25 biologic biologic NOUN dpc-4458 34 26 agents agent NOUN dpc-4458 34 27 such such ADJ dpc-4458 34 28 as as ADP dpc-4458 34 29 adalimumab adalimumab NOUN dpc-4458 34 30 , , PUNCT dpc-4458 34 31 ustekinumab ustekinumab NOUN dpc-4458 34 32 , , PUNCT dpc-4458 34 33 secukinumab secukinumab NOUN dpc-4458 34 34 , , PUNCT dpc-4458 34 35 or or CCONJ dpc-4458 34 36 ixekizumab ixekizumab NOUN dpc-4458 34 37 more more ADV dpc-4458 34 38 frequently frequently ADV dpc-4458 34 39 considered consider VERB dpc-4458 34 40 [ [ PUNCT dpc-4458 34 41 6 6 NUM dpc-4458 34 42 ] ] PUNCT dpc-4458 34 43 . . PUNCT dpc-4458 35 1 however however ADV dpc-4458 35 2 , , PUNCT dpc-4458 35 3 given give VERB dpc-4458 35 4 the the DET dpc-4458 35 5 highly highly ADV dpc-4458 35 6 heterogeneous heterogeneous ADJ dpc-4458 35 7 character character NOUN dpc-4458 35 8 of of ADP dpc-4458 35 9 psoriasis psoriasis NOUN dpc-4458 35 10 , , PUNCT dpc-4458 35 11 biologic biologic NOUN dpc-4458 35 12 therapies therapy NOUN dpc-4458 35 13 are be AUX dpc-4458 35 14 suitable suitable ADJ dpc-4458 35 15 for for ADP dpc-4458 35 16 only only ADV dpc-4458 35 17 a a DET dpc-4458 35 18 minority minority NOUN dpc-4458 35 19 of of ADP dpc-4458 35 20 patients patient NOUN dpc-4458 35 21 . . PUNCT dpc-4458 36 1 bullous bullous ADJ dpc-4458 36 2 pemphigoid pemphigoid NOUN dpc-4458 36 3 ( ( PUNCT dpc-4458 36 4 bp bp PROPN dpc-4458 36 5 ) ) PUNCT dpc-4458 36 6 is be AUX dpc-4458 36 7 the the DET dpc-4458 36 8 major major ADJ dpc-4458 36 9 type type NOUN dpc-4458 36 10 of of ADP dpc-4458 36 11 pemphigoid pemphigoid NOUN dpc-4458 36 12 , , PUNCT dpc-4458 36 13 belonging belong VERB dpc-4458 36 14 to to ADP dpc-4458 36 15 an an DET dpc-4458 36 16 autoantibody autoantibody ADJ dpc-4458 36 17 - - PUNCT dpc-4458 36 18 mediated mediate VERB dpc-4458 36 19 blistering blistering ADJ dpc-4458 36 20 skin skin NOUN dpc-4458 36 21 disease disease NOUN dpc-4458 36 22 [ [ X dpc-4458 36 23 7 7 NUM dpc-4458 36 24 ] ] PUNCT dpc-4458 36 25 . . PUNCT dpc-4458 37 1 bp bp PROPN dpc-4458 37 2 primarily primarily ADV dpc-4458 37 3 affects affect VERB dpc-4458 37 4 the the DET dpc-4458 37 5 elderly elderly ADJ dpc-4458 37 6 ( ( PUNCT dpc-4458 37 7 with with ADP dpc-4458 37 8 an an DET dpc-4458 37 9 average average ADJ dpc-4458 37 10 age age NOUN dpc-4458 37 11 of of ADP dpc-4458 37 12 80 80 NUM dpc-4458 37 13 years year NOUN dpc-4458 37 14 at at ADP dpc-4458 37 15 presentation presentation NOUN dpc-4458 37 16 ) ) PUNCT dpc-4458 37 17 , , PUNCT dpc-4458 37 18 and and CCONJ dpc-4458 37 19 the the DET dpc-4458 37 20 death death NOUN dpc-4458 37 21 rate rate NOUN dpc-4458 37 22 is be AUX dpc-4458 37 23 three three NUM dpc-4458 37 24 times time NOUN dpc-4458 37 25 higher high ADJ dpc-4458 37 26 than than ADP dpc-4458 37 27 that that PRON dpc-4458 37 28 of of ADP dpc-4458 37 29 controls control NOUN dpc-4458 37 30 ( ( PUNCT dpc-4458 37 31 pemphigus pemphigus NOUN dpc-4458 37 32 vulgaris vulgaris NOUN dpc-4458 37 33 ) ) PUNCT dpc-4458 37 34 , , PUNCT dpc-4458 37 35 statistically statistically ADV dpc-4458 37 36 [ [ X dpc-4458 37 37 8 8 NUM dpc-4458 37 38 ] ] PUNCT dpc-4458 37 39 . . PUNCT dpc-4458 38 1 tense tense ADJ dpc-4458 38 2 bullae bullae NOUN dpc-4458 38 3 that that PRON dpc-4458 38 4 appear appear VERB dpc-4458 38 5 on on ADP dpc-4458 38 6 erythematous erythematous ADJ dpc-4458 38 7 or or CCONJ dpc-4458 38 8 normal normal ADJ dpc-4458 38 9 skin skin NOUN dpc-4458 38 10 are be AUX dpc-4458 38 11 the the DET dpc-4458 38 12 clinical clinical ADJ dpc-4458 38 13 features feature NOUN dpc-4458 38 14 of of ADP dpc-4458 38 15 bp bp PROPN dpc-4458 39 1 [ [ X dpc-4458 39 2 9 9 NUM dpc-4458 39 3 ] ] PUNCT dpc-4458 39 4 . . PUNCT dpc-4458 40 1 subepidermal subepidermal NOUN dpc-4458 40 2 blisters blister NOUN dpc-4458 40 3 with with ADP dpc-4458 40 4 inflammation inflammation NOUN dpc-4458 40 5 are be AUX dpc-4458 40 6 the the DET dpc-4458 40 7 histological histological ADJ dpc-4458 40 8 hallmark hallmark NOUN dpc-4458 40 9 of of ADP dpc-4458 40 10 bp bp PROPN dpc-4458 40 11 , , PUNCT dpc-4458 40 12 and and CCONJ dpc-4458 40 13 eosinophils eosinophil NOUN dpc-4458 40 14 are be AUX dpc-4458 40 15 frequently frequently ADV dpc-4458 40 16 observed observe VERB dpc-4458 40 17 in in ADP dpc-4458 40 18 the the DET dpc-4458 40 19 blister blister NOUN dpc-4458 40 20 cavity cavity NOUN dpc-4458 40 21 and and CCONJ dpc-4458 40 22 at at ADP dpc-4458 40 23 the the DET dpc-4458 40 24 intact intact ADJ dpc-4458 40 25 basement basement NOUN dpc-4458 40 26 membrane membrane NOUN dpc-4458 40 27 zone zone NOUN dpc-4458 40 28 [ [ X dpc-4458 40 29 9 9 NUM dpc-4458 40 30 ] ] PUNCT dpc-4458 40 31 . . PUNCT dpc-4458 41 1 corticosteroids corticosteroid NOUN dpc-4458 41 2 , , PUNCT dpc-4458 41 3 azathioprine azathioprine NOUN dpc-4458 41 4 , , PUNCT dpc-4458 41 5 and and CCONJ dpc-4458 41 6 plasmapheresis plasmapheresis NOUN dpc-4458 41 7 are be AUX dpc-4458 41 8 treatment treatment NOUN dpc-4458 41 9 options option NOUN dpc-4458 41 10 for for ADP dpc-4458 41 11 bp bp PROPN dpc-4458 42 1 [ [ X dpc-4458 42 2 10 10 NUM dpc-4458 42 3 ] ] PUNCT dpc-4458 42 4 . . PUNCT dpc-4458 43 1 recently recently ADV dpc-4458 43 2 , , PUNCT dpc-4458 43 3 studies study NOUN dpc-4458 43 4 have have AUX dpc-4458 43 5 reported report VERB dpc-4458 43 6 the the DET dpc-4458 43 7 association association NOUN dpc-4458 43 8 between between ADP dpc-4458 43 9 bp bp PROPN dpc-4458 43 10 and and CCONJ dpc-4458 43 11 other other ADJ dpc-4458 43 12 diseases disease NOUN dpc-4458 43 13 . . PUNCT dpc-4458 44 1 accordingly accordingly ADV dpc-4458 44 2 , , PUNCT dpc-4458 44 3 compared compare VERB dpc-4458 44 4 to to ADP dpc-4458 44 5 matched match VERB dpc-4458 44 6 controls control NOUN dpc-4458 44 7 , , PUNCT dpc-4458 44 8 patients patient NOUN dpc-4458 44 9 with with ADP dpc-4458 44 10 bp bp PROPN dpc-4458 44 11 have have VERB dpc-4458 44 12 a a DET dpc-4458 44 13 threefold threefold ADV dpc-4458 44 14 increased increase VERB dpc-4458 44 15 risk risk NOUN dpc-4458 44 16 of of ADP dpc-4458 44 17 developing develop VERB dpc-4458 44 18 pneumonia pneumonia NOUN dpc-4458 44 19 and and CCONJ dpc-4458 44 20 pulmonary pulmonary ADJ dpc-4458 44 21 embolism embolism NOUN dpc-4458 44 22 [ [ X dpc-4458 44 23 8 8 NUM dpc-4458 44 24 ] ] PUNCT dpc-4458 44 25 , , PUNCT dpc-4458 44 26 and and CCONJ dpc-4458 44 27 between between ADP dpc-4458 44 28 30 30 NUM dpc-4458 44 29 % % NOUN dpc-4458 44 30 and and CCONJ dpc-4458 44 31 50 50 NUM dpc-4458 44 32 % % NOUN dpc-4458 44 33 of of ADP dpc-4458 44 34 bp bp PROPN dpc-4458 44 35 patients patient NOUN dpc-4458 44 36 have have VERB dpc-4458 44 37 neurological neurological ADJ dpc-4458 44 38 diseases disease NOUN dpc-4458 44 39 [ [ X dpc-4458 44 40 11 11 NUM dpc-4458 44 41 ] ] PUNCT dpc-4458 44 42 . . PUNCT dpc-4458 45 1 as as SCONJ dpc-4458 45 2 mentioned mention VERB dpc-4458 45 3 , , PUNCT dpc-4458 45 4 psoriasis psoriasis NOUN dpc-4458 45 5 and and CCONJ dpc-4458 45 6 bp bp PROPN dpc-4458 45 7 are be AUX dpc-4458 45 8 common common ADJ dpc-4458 45 9 immune immune ADJ dpc-4458 45 10 related relate VERB dpc-4458 45 11 dermatological dermatological ADJ dpc-4458 45 12 diseases disease NOUN dpc-4458 45 13 , , PUNCT dpc-4458 45 14 and and CCONJ dpc-4458 45 15 studies study NOUN dpc-4458 45 16 have have AUX dpc-4458 45 17 also also ADV dpc-4458 45 18 reported report VERB dpc-4458 45 19 the the DET dpc-4458 45 20 association association NOUN dpc-4458 45 21 of of ADP dpc-4458 45 22 bp bp PROPN dpc-4458 45 23 with with ADP dpc-4458 45 24 psoriasis psoriasis NOUN dpc-4458 45 25 [ [ X dpc-4458 45 26 12 12 NUM dpc-4458 45 27 ] ] PUNCT dpc-4458 45 28 . . PUNCT dpc-4458 46 1 whether whether SCONJ dpc-4458 46 2 a a DET dpc-4458 46 3 causal causal ADJ dpc-4458 46 4 relationship relationship NOUN dpc-4458 46 5 exists exist VERB dpc-4458 46 6 between between ADP dpc-4458 46 7 psoriasis psoriasis NOUN dpc-4458 46 8 and and CCONJ dpc-4458 46 9 bp bp PROPN dpc-4458 46 10 remains remain VERB dpc-4458 46 11 unclear unclear ADJ dpc-4458 46 12 . . PUNCT dpc-4458 47 1 objectives objective NOUN dpc-4458 47 2 mendelian mendelian ADJ dpc-4458 47 3 randomization randomization NOUN dpc-4458 47 4 ( ( PUNCT dpc-4458 47 5 mr mr PROPN dpc-4458 47 6 ) ) PUNCT dpc-4458 47 7 is be AUX dpc-4458 47 8 an an DET dpc-4458 47 9 emerging emerge VERB dpc-4458 47 10 method method NOUN dpc-4458 47 11 to to PART dpc-4458 47 12 determine determine VERB dpc-4458 47 13 the the DET dpc-4458 47 14 existence existence NOUN dpc-4458 47 15 and and CCONJ dpc-4458 47 16 the the DET dpc-4458 47 17 strength strength NOUN dpc-4458 47 18 of of ADP dpc-4458 47 19 the the DET dpc-4458 47 20 causal causal ADJ dpc-4458 47 21 relationship relationship NOUN dpc-4458 47 22 between between ADP dpc-4458 47 23 an an DET dpc-4458 47 24 exposure exposure NOUN dpc-4458 47 25 and and CCONJ dpc-4458 47 26 an an DET dpc-4458 47 27 outcome outcome NOUN dpc-4458 47 28 [ [ X dpc-4458 47 29 13 13 NUM dpc-4458 47 30 ] ] PUNCT dpc-4458 47 31 . . PUNCT dpc-4458 48 1 in in ADP dpc-4458 48 2 mr mr PROPN dpc-4458 48 3 , , PUNCT dpc-4458 48 4 researchers researcher NOUN dpc-4458 48 5 need need VERB dpc-4458 48 6 to to PART dpc-4458 48 7 choose choose VERB dpc-4458 48 8 single single ADJ dpc-4458 48 9 nucleotide nucleotide ADJ dpc-4458 48 10 polymorphisms polymorphism NOUN dpc-4458 48 11 ( ( PUNCT dpc-4458 48 12 snps snps PROPN dpc-4458 48 13 ) ) PUNCT dpc-4458 48 14 and and CCONJ dpc-4458 48 15 use use VERB dpc-4458 48 16 them they PRON dpc-4458 48 17 as as ADP dpc-4458 48 18 instrument instrument NOUN dpc-4458 48 19 variables variable NOUN dpc-4458 48 20 ( ( PUNCT dpc-4458 48 21 ivs ivs NOUN dpc-4458 48 22 ) ) PUNCT dpc-4458 49 1 [ [ X dpc-4458 49 2 14 14 NUM dpc-4458 49 3 ] ] PUNCT dpc-4458 49 4 . . PUNCT dpc-4458 50 1 different different ADJ dpc-4458 50 2 from from ADP dpc-4458 50 3 a a DET dpc-4458 50 4 randomized randomized ADJ dpc-4458 50 5 controlled control VERB dpc-4458 50 6 trial trial NOUN dpc-4458 50 7 , , PUNCT dpc-4458 50 8 which which PRON dpc-4458 50 9 is be AUX dpc-4458 50 10 typically typically ADV dpc-4458 50 11 expensive expensive ADJ dpc-4458 50 12 , , PUNCT dpc-4458 50 13 time time NOUN dpc-4458 50 14 - - PUNCT dpc-4458 50 15 consuming consume VERB dpc-4458 50 16 , , PUNCT dpc-4458 50 17 and and CCONJ dpc-4458 50 18 sometimes sometimes ADV dpc-4458 50 19 infeasible infeasible ADJ dpc-4458 50 20 , , PUNCT dpc-4458 50 21 mr mr PROPN dpc-4458 50 22 relies rely VERB dpc-4458 50 23 on on ADP dpc-4458 50 24 observational observational ADJ dpc-4458 50 25 data datum NOUN dpc-4458 50 26 [ [ X dpc-4458 50 27 14 14 NUM dpc-4458 50 28 ] ] PUNCT dpc-4458 50 29 . . PUNCT dpc-4458 51 1 in in ADP dpc-4458 51 2 order order NOUN dpc-4458 51 3 to to PART dpc-4458 51 4 identify identify VERB dpc-4458 51 5 any any DET dpc-4458 51 6 causal causal ADJ dpc-4458 51 7 influence influence NOUN dpc-4458 51 8 between between ADP dpc-4458 51 9 psoriasis psoriasis NOUN dpc-4458 51 10 and and CCONJ dpc-4458 51 11 bp bp PROPN dpc-4458 51 12 , , PUNCT dpc-4458 51 13 we we PRON dpc-4458 51 14 carried carry VERB dpc-4458 51 15 out out ADP dpc-4458 51 16 a a DET dpc-4458 51 17 bidirectional bidirectional ADJ dpc-4458 51 18 mr mr PROPN dpc-4458 51 19 analysis analysis NOUN dpc-4458 51 20 . . PUNCT dpc-4458 52 1 based base VERB dpc-4458 52 2 on on ADP dpc-4458 52 3 genome genome NOUN dpc-4458 52 4 - - PUNCT dpc-4458 52 5 wide wide ADJ dpc-4458 52 6 association association NOUN dpc-4458 52 7 studies study NOUN dpc-4458 52 8 ( ( PUNCT dpc-4458 52 9 gwas gwas PROPN dpc-4458 52 10 ) ) PUNCT dpc-4458 52 11 , , PUNCT dpc-4458 52 12 genetic genetic ADJ dpc-4458 52 13 variants variant NOUN dpc-4458 52 14 related relate VERB dpc-4458 52 15 to to ADP dpc-4458 52 16 psoriasis psoriasis NOUN dpc-4458 52 17 and and CCONJ dpc-4458 52 18 bp bp PROPN dpc-4458 52 19 were be AUX dpc-4458 52 20 screened screen VERB dpc-4458 52 21 as as ADP dpc-4458 52 22 instrumental instrumental ADJ dpc-4458 52 23 variables variable NOUN dpc-4458 52 24 ( ( PUNCT dpc-4458 52 25 ivs ivs NOUN dpc-4458 52 26 ) ) PUNCT dpc-4458 52 27 . . PUNCT dpc-4458 53 1 methods method NOUN dpc-4458 53 2 study study VERB dpc-4458 53 3 design design NOUN dpc-4458 53 4 figure figure NOUN dpc-4458 53 5 1 1 NUM dpc-4458 53 6 shows show VERB dpc-4458 53 7 our our PRON dpc-4458 53 8 mr mr PROPN dpc-4458 53 9 framework framework NOUN dpc-4458 53 10 . . PUNCT dpc-4458 54 1 in in ADP dpc-4458 54 2 this this DET dpc-4458 54 3 study study NOUN dpc-4458 54 4 , , PUNCT dpc-4458 54 5 there there PRON dpc-4458 54 6 were be VERB dpc-4458 54 7 three three NUM dpc-4458 54 8 key key ADJ dpc-4458 54 9 assumptions assumption NOUN dpc-4458 54 10 : : PUNCT dpc-4458 54 11 1 1 X dpc-4458 54 12 . . X dpc-4458 54 13 relevance relevance NOUN dpc-4458 54 14 assumption assumption NOUN dpc-4458 54 15 : : PUNCT dpc-4458 54 16 single single ADJ dpc-4458 54 17 nucleotide nucleotide ADJ dpc-4458 54 18 polymorphisms polymorphism NOUN dpc-4458 54 19 ( ( PUNCT dpc-4458 54 20 snps snps PROPN dpc-4458 54 21 ) ) PUNCT dpc-4458 54 22 that that PRON dpc-4458 54 23 are be AUX dpc-4458 54 24 substantially substantially ADV dpc-4458 54 25 linked link VERB dpc-4458 54 26 to to ADP dpc-4458 54 27 exposures exposure NOUN dpc-4458 54 28 are be AUX dpc-4458 54 29 used use VERB dpc-4458 54 30 as as ADP dpc-4458 54 31 instrumental instrumental ADJ dpc-4458 54 32 variables variable NOUN dpc-4458 54 33 ( ( PUNCT dpc-4458 54 34 ivs ivs NOUN dpc-4458 54 35 ) ) PUNCT dpc-4458 54 36 . . PUNCT dpc-4458 55 1 2 2 X dpc-4458 55 2 . . X dpc-4458 55 3 independence independence NOUN dpc-4458 55 4 assumption assumption NOUN dpc-4458 55 5 : : PUNCT dpc-4458 55 6 these these DET dpc-4458 55 7 snps snps PROPN dpc-4458 55 8 ( ( PUNCT dpc-4458 55 9 ivs ivs PROPN dpc-4458 55 10 ) ) PUNCT dpc-4458 55 11 should should AUX dpc-4458 55 12 not not PART dpc-4458 55 13 show show VERB dpc-4458 55 14 any any DET dpc-4458 55 15 correlation correlation NOUN dpc-4458 55 16 with with ADP dpc-4458 55 17 the the DET dpc-4458 55 18 relevant relevant ADJ dpc-4458 55 19 confounding confound VERB dpc-4458 55 20 factor factor NOUN dpc-4458 55 21 . . PUNCT dpc-4458 56 1 3 3 X dpc-4458 56 2 . . X dpc-4458 56 3 exclusivity exclusivity NOUN dpc-4458 56 4 assumption assumption NOUN dpc-4458 56 5 : : PUNCT dpc-4458 56 6 these these DET dpc-4458 56 7 snps snps PROPN dpc-4458 56 8 ( ( PUNCT dpc-4458 56 9 ivs ivs PROPN dpc-4458 56 10 ) ) PUNCT dpc-4458 56 11 should should AUX dpc-4458 56 12 affect affect VERB dpc-4458 56 13 outcomes outcome NOUN dpc-4458 56 14 only only ADV dpc-4458 56 15 through through ADP dpc-4458 56 16 their their PRON dpc-4458 56 17 effect effect NOUN dpc-4458 56 18 on on ADP dpc-4458 56 19 exposure exposure NOUN dpc-4458 56 20 [ [ X dpc-4458 56 21 15 15 NUM dpc-4458 56 22 , , PUNCT dpc-4458 56 23 16 16 NUM dpc-4458 56 24 ] ] PUNCT dpc-4458 56 25 . . PUNCT dpc-4458 57 1 gwas gwas PROPN dpc-4458 57 2 summary summary PROPN dpc-4458 57 3 data datum NOUN dpc-4458 57 4 source source NOUN dpc-4458 57 5 we we PRON dpc-4458 57 6 retrospectively retrospectively ADV dpc-4458 57 7 used use VERB dpc-4458 57 8 summary summary NOUN dpc-4458 57 9 data datum NOUN dpc-4458 57 10 associated associate VERB dpc-4458 57 11 with with ADP dpc-4458 57 12 psoriasis psoriasis NOUN dpc-4458 57 13 and and CCONJ dpc-4458 57 14 bp bp PROPN dpc-4458 57 15 from from ADP dpc-4458 57 16 mrc mrc NOUN dpc-4458 57 17 integrative integrative ADJ dpc-4458 57 18 epidemiology epidemiology NOUN dpc-4458 57 19 unit unit NOUN dpc-4458 57 20 open open ADJ dpc-4458 57 21 gwas gwas PROPN dpc-4458 57 22 database database NOUN dpc-4458 57 23 ( ( PUNCT dpc-4458 57 24 https://gwas.mrcieu.ac.uk https://gwas.mrcieu.ac.uk PROPN dpc-4458 57 25 ) ) PUNCT dpc-4458 57 26 and and CCONJ dpc-4458 57 27 finngen finngen NOUN dpc-4458 57 28 ( ( PUNCT dpc-4458 57 29 https://www.finngen.fi/en/access_results https://www.finngen.fi/en/access_result NOUN dpc-4458 57 30 ) ) PUNCT dpc-4458 57 31 . . PUNCT dpc-4458 58 1 accession accession NOUN dpc-4458 58 2 numbers number NOUN dpc-4458 58 3 ebi ebi VERB dpc-4458 58 4 - - PUNCT dpc-4458 58 5 a a DET dpc-4458 58 6 - - PUNCT dpc-4458 58 7 gcst90018907 gcst90018907 PROPN dpc-4458 58 8 ( ( PUNCT dpc-4458 58 9 psoriasis psoriasis NOUN dpc-4458 58 10 5,072 5,072 NUM dpc-4458 58 11 cases case NOUN dpc-4458 58 12 ; ; PUNCT dpc-4458 58 13 478,102 478,102 NUM dpc-4458 58 14 controls control NOUN dpc-4458 58 15 ) ) PUNCT dpc-4458 59 1 [ [ X dpc-4458 59 2 17 17 NUM dpc-4458 59 3 ] ] PUNCT dpc-4458 59 4 , , PUNCT dpc-4458 59 5 ukb ukb PROPN dpc-4458 59 6 - - PUNCT dpc-4458 59 7 b-10537 b-10537 ADJ dpc-4458 59 8 ( ( PUNCT dpc-4458 59 9 psoriasis psoriasis NOUN dpc-4458 59 10 5,314 5,314 NUM dpc-4458 59 11 cases case NOUN dpc-4458 59 12 ; ; PUNCT dpc-4458 59 13 457,619 457,619 NUM dpc-4458 59 14 controls control NOUN dpc-4458 59 15 ) ) PUNCT dpc-4458 59 16 , , PUNCT dpc-4458 59 17 finn finn PROPN dpc-4458 59 18 - - PUNCT dpc-4458 59 19 b b NOUN dpc-4458 59 20 - - PUNCT dpc-4458 59 21 l12_psori_vulg l12_psori_vulg ADJ dpc-4458 59 22 ( ( PUNCT dpc-4458 59 23 psoriasis psoriasis NOUN dpc-4458 59 24 2,802 2,802 NUM dpc-4458 59 25 cases case NOUN dpc-4458 59 26 ; ; PUNCT dpc-4458 59 27 212,242 212,242 NUM dpc-4458 59 28 controls control NOUN dpc-4458 59 29 ) ) PUNCT dpc-4458 59 30 ; ; PUNCT dpc-4458 59 31 finn finn PROPN dpc-4458 59 32 - - PUNCT dpc-4458 59 33 b b PROPN dpc-4458 59 34 - - PUNCT dpc-4458 59 35 l12_pemphigoid_bull l12_pemphigoid_bull NOUN dpc-4458 59 36 ( ( PUNCT dpc-4458 59 37 bp bp PROPN dpc-4458 59 38 219 219 NUM dpc-4458 59 39 cases case NOUN dpc-4458 59 40 ; ; PUNCT dpc-4458 59 41 218,066 218,066 NUM dpc-4458 59 42 controls control NOUN dpc-4458 59 43 ) ) PUNCT dpc-4458 59 44 summary summary NOUN dpc-4458 59 45 data datum NOUN dpc-4458 59 46 were be AUX dpc-4458 59 47 accessed access VERB dpc-4458 59 48 from from ADP dpc-4458 59 49 ieu ieu PROPN dpc-4458 59 50 open open PROPN dpc-4458 59 51 gwas gwas PROPN dpc-4458 59 52 project project NOUN dpc-4458 59 53 database database NOUN dpc-4458 59 54 ( ( PUNCT dpc-4458 59 55 https:// https:// PROPN dpc-4458 59 56 gwas.mrcieu.ac.uk gwas.mrcieu.ac.uk PROPN dpc-4458 59 57 ) ) PUNCT dpc-4458 59 58 . . PUNCT dpc-4458 60 1 our our PRON dpc-4458 60 2 study study NOUN dpc-4458 60 3 was be AUX dpc-4458 60 4 conducted conduct VERB dpc-4458 60 5 by by ADP dpc-4458 60 6 secondary secondary ADJ dpc-4458 60 7 analysis analysis NOUN dpc-4458 60 8 of of ADP dpc-4458 60 9 data datum NOUN dpc-4458 60 10 from from ADP dpc-4458 60 11 other other ADJ dpc-4458 60 12 studies study NOUN dpc-4458 60 13 . . PUNCT dpc-4458 61 1 all all DET dpc-4458 61 2 participants participant NOUN dpc-4458 61 3 or or CCONJ dpc-4458 61 4 their their PRON dpc-4458 61 5 family family NOUN dpc-4458 61 6 members member NOUN dpc-4458 61 7 provided provide VERB dpc-4458 61 8 informed informed ADJ dpc-4458 61 9 written write VERB dpc-4458 61 10 consent consent NOUN dpc-4458 61 11 in in ADP dpc-4458 61 12 the the DET dpc-4458 61 13 original original ADJ dpc-4458 61 14 studies study NOUN dpc-4458 61 15 . . PUNCT dpc-4458 62 1 detailed detailed ADJ dpc-4458 62 2 information information NOUN dpc-4458 62 3 of of ADP dpc-4458 62 4 data datum NOUN dpc-4458 62 5 elements element NOUN dpc-4458 62 6 for for ADP dpc-4458 62 7 psoriasis psoriasis NOUN dpc-4458 62 8 and and CCONJ dpc-4458 62 9 bp bp PROPN dpc-4458 62 10 was be AUX dpc-4458 62 11 listed list VERB dpc-4458 62 12 in in ADP dpc-4458 62 13 table table NOUN dpc-4458 62 14 1 1 NUM dpc-4458 62 15 . . PUNCT dpc-4458 63 1 instrumental instrumental ADJ dpc-4458 63 2 variables variable NOUN dpc-4458 63 3 selection selection NOUN dpc-4458 63 4 related relate VERB dpc-4458 63 5 ivs ivs NOUN dpc-4458 63 6     SPACE dpc-4458 63 7 for for ADP dpc-4458 63 8 mr mr PROPN dpc-4458 63 9 analysis analysis NOUN dpc-4458 63 10 followed follow VERB dpc-4458 63 11 particular particular ADJ dpc-4458 63 12 principles principle NOUN dpc-4458 63 13 : : PUNCT dpc-4458 63 14     SPACE dpc-4458 63 15 snps snps PROPN dpc-4458 63 16 should should AUX dpc-4458 63 17 be be AUX dpc-4458 63 18 associated associate VERB dpc-4458 63 19 with with ADP dpc-4458 63 20 exposures exposure NOUN dpc-4458 63 21 at at ADP dpc-4458 63 22 the the DET dpc-4458 63 23 locus locus NOUN dpc-4458 63 24 - - PUNCT dpc-4458 63 25 wide wide ADJ dpc-4458 63 26 significance significance NOUN dpc-4458 63 27 level level NOUN dpc-4458 63 28 ( ( PUNCT dpc-4458 63 29 p p X dpc-4458 63 30 < < X dpc-4458 63 31 5e-06 5e-06 NOUN dpc-4458 63 32 for for ADP dpc-4458 63 33 psoriasis psoriasis NOUN dpc-4458 63 34 , , PUNCT dpc-4458 63 35 original original ADJ dpc-4458 63 36 article article NOUN dpc-4458 63 37 | | ADV dpc-4458 63 38 dermatol dermatol ADJ dpc-4458 63 39 pract pract NOUN dpc-4458 63 40 concept concept NOUN dpc-4458 63 41 . . PUNCT dpc-4458 64 1 2025;15(1):4458 2025;15(1):4458 NUM dpc-4458 64 2 3 3 NUM dpc-4458 65 1 p p NOUN dpc-4458 65 2     SPACE dpc-4458 65 3 < < X dpc-4458 65 4 5e-08 5e-08 NOUN dpc-4458 65 5 for for ADP dpc-4458 65 6 bp bp PROPN dpc-4458 65 7 ) ) PUNCT dpc-4458 65 8 . . PUNCT dpc-4458 66 1 in in ADP dpc-4458 66 2 addition addition NOUN dpc-4458 66 3 , , PUNCT dpc-4458 66 4 linkage linkage NOUN dpc-4458 66 5 disequilibrium disequilibrium NOUN dpc-4458 66 6 ( ( PUNCT dpc-4458 66 7 ld ld NOUN dpc-4458 66 8 ) ) PUNCT dpc-4458 66 9 coefficient coefficient NOUN dpc-4458 66 10 r2 r2 PROPN dpc-4458 66 11 should should AUX dpc-4458 66 12 be be AUX dpc-4458 66 13 less less ADJ dpc-4458 66 14 than than ADP dpc-4458 66 15 0.001 0.001 NUM dpc-4458 66 16 , , PUNCT dpc-4458 66 17 not not PART dpc-4458 66 18 closely closely ADV dpc-4458 66 19 related relate VERB dpc-4458 66 20 ( ( PUNCT dpc-4458 66 21 clumping clump VERB dpc-4458 66 22 window window NOUN dpc-4458 66 23 more more ADJ dpc-4458 66 24 than than ADP dpc-4458 66 25 10,000 10,000 NUM dpc-4458 66 26 kb kb NOUN dpc-4458 66 27 ) ) PUNCT dpc-4458 66 28 to to PART dpc-4458 66 29 ensure ensure VERB dpc-4458 66 30 exposure exposure NOUN dpc-4458 66 31 instrument instrument NOUN dpc-4458 66 32 independence independence NOUN dpc-4458 66 33 . . PUNCT dpc-4458 67 1 we we PRON dpc-4458 67 2 used use VERB dpc-4458 67 3 the the DET dpc-4458 67 4 f f PROPN dpc-4458 67 5 statistic statistic NOUN dpc-4458 67 6 to to PART dpc-4458 67 7 measure measure VERB dpc-4458 67 8 the the DET dpc-4458 67 9 strength strength NOUN dpc-4458 67 10 of of ADP dpc-4458 67 11 the the DET dpc-4458 67 12 ivs ivs NOUN dpc-4458 67 13 ; ; PUNCT dpc-4458 67 14 the the DET dpc-4458 67 15 values value NOUN dpc-4458 67 16 of of ADP dpc-4458 67 17 f f PROPN dpc-4458 67 18 - - PUNCT dpc-4458 67 19 statistics statistic NOUN dpc-4458 67 20 were be AUX dpc-4458 67 21 more more ADJ dpc-4458 67 22 than than ADP dpc-4458 67 23 10 10 NUM dpc-4458 67 24 . . PUNCT dpc-4458 68 1 mr mr PROPN dpc-4458 68 2 analysis analysis NOUN dpc-4458 68 3 causal causal ADJ dpc-4458 68 4 relationships relationship NOUN dpc-4458 68 5 between between ADP dpc-4458 68 6 psoriasis psoriasis NOUN dpc-4458 68 7 and and CCONJ dpc-4458 68 8 bullous bullous ADJ dpc-4458 68 9 pemphigoid pemphigoid NOUN dpc-4458 68 10 ( ( PUNCT dpc-4458 68 11 bp bp PROPN dpc-4458 68 12 ) ) PUNCT dpc-4458 68 13 were be AUX dpc-4458 68 14 investigated investigate VERB dpc-4458 68 15 utilizing utilize VERB dpc-4458 68 16 mendelian mendelian ADJ dpc-4458 68 17 randomization randomization NOUN dpc-4458 68 18 ( ( PUNCT dpc-4458 68 19 mr mr PROPN dpc-4458 68 20 ) ) PUNCT dpc-4458 68 21 and and CCONJ dpc-4458 68 22 reverse reverse VERB dpc-4458 68 23 causality causality NOUN dpc-4458 68 24 analysis analysis NOUN dpc-4458 68 25 ( ( PUNCT dpc-4458 68 26 supplementary supplementary ADJ dpc-4458 68 27 table table NOUN dpc-4458 68 28 s1 s1 NOUN dpc-4458 68 29 ) ) PUNCT dpc-4458 68 30 . . PUNCT dpc-4458 69 1 in in ADP dpc-4458 69 2 the the DET dpc-4458 69 3 assessment assessment NOUN dpc-4458 69 4 of of ADP dpc-4458 69 5 exposure exposure NOUN dpc-4458 69 6 and and CCONJ dpc-4458 69 7 outcome outcome NOUN dpc-4458 69 8 , , PUNCT dpc-4458 69 9 we we PRON dpc-4458 69 10 employed employ VERB dpc-4458 69 11 mr mr PROPN dpc-4458 69 12 with with ADP dpc-4458 69 13 multiple multiple ADJ dpc-4458 69 14 single single ADJ dpc-4458 69 15 nucleotide nucleotide ADJ dpc-4458 69 16 polymorphisms polymorphism NOUN dpc-4458 69 17 ( ( PUNCT dpc-4458 69 18 snps snps NOUN dpc-4458 69 19 ) ) PUNCT dpc-4458 69 20 serving serve VERB dpc-4458 69 21 as as ADP dpc-4458 69 22 instrumental instrumental ADJ dpc-4458 69 23 variables variable NOUN dpc-4458 69 24 ( ( PUNCT dpc-4458 69 25 ivs ivs NOUN dpc-4458 69 26 ) ) PUNCT dpc-4458 69 27 . . PUNCT dpc-4458 70 1 each each DET dpc-4458 70 2 iv iv NOUN dpc-4458 70 3 provides provide VERB dpc-4458 70 4 an an DET dpc-4458 70 5 independent independent ADJ dpc-4458 70 6 estimate estimate NOUN dpc-4458 70 7 of of ADP dpc-4458 70 8 the the DET dpc-4458 70 9 causal causal ADJ dpc-4458 70 10 effect effect NOUN dpc-4458 70 11 , , PUNCT dpc-4458 70 12 which which PRON dpc-4458 70 13 can can AUX dpc-4458 70 14 be be AUX dpc-4458 70 15 aggregated aggregate VERB dpc-4458 70 16 through through ADP dpc-4458 70 17 a a DET dpc-4458 70 18 fixed fix VERB dpc-4458 70 19 effect effect NOUN dpc-4458 70 20 , , PUNCT dpc-4458 70 21 inverse inverse ADJ dpc-4458 70 22 variance variance NOUN dpc-4458 70 23 - - PUNCT dpc-4458 70 24 weighted weight VERB dpc-4458 70 25 ( ( PUNCT dpc-4458 70 26 ivw ivw NOUN dpc-4458 70 27 ) ) PUNCT dpc-4458 70 28 meta meta NOUN dpc-4458 70 29 - - PUNCT dpc-4458 70 30 analysis analysis NOUN dpc-4458 70 31 . . PUNCT dpc-4458 71 1 the the DET dpc-4458 71 2 primary primary ADJ dpc-4458 71 3 statistical statistical ADJ dpc-4458 71 4 analysis analysis NOUN dpc-4458 71 5 for for ADP dpc-4458 71 6 assessing assess VERB dpc-4458 71 7 causal causal ADJ dpc-4458 71 8 effects effect NOUN dpc-4458 71 9 was be AUX dpc-4458 71 10 performed perform VERB dpc-4458 71 11 using use VERB dpc-4458 71 12 the the DET dpc-4458 71 13 ivw ivw NOUN dpc-4458 71 14 method method NOUN dpc-4458 71 15 , , PUNCT dpc-4458 71 16 complemented complement VERB dpc-4458 71 17 by by ADP dpc-4458 71 18 additional additional ADJ dpc-4458 71 19 approaches approach NOUN dpc-4458 71 20 such such ADJ dpc-4458 71 21 as as ADP dpc-4458 71 22 simple simple ADJ dpc-4458 71 23 mode mode NOUN dpc-4458 71 24 , , PUNCT dpc-4458 71 25 weighted weight VERB dpc-4458 71 26 median median NOUN dpc-4458 71 27 , , PUNCT dpc-4458 71 28 weighted weighted ADJ dpc-4458 71 29 mode mode NOUN dpc-4458 71 30 , , PUNCT dpc-4458 71 31 and and CCONJ dpc-4458 71 32 mr mr PROPN dpc-4458 71 33 - - PUNCT dpc-4458 71 34 egger egger NOUN dpc-4458 71 35 to to PART dpc-4458 71 36 further far ADV dpc-4458 71 37 validate validate VERB dpc-4458 71 38 the the DET dpc-4458 71 39 results result NOUN dpc-4458 71 40 . . PUNCT dpc-4458 72 1 the the DET dpc-4458 72 2 mr mr PROPN dpc-4458 72 3 - - PUNCT dpc-4458 72 4 egger egger NOUN dpc-4458 72 5 method method NOUN dpc-4458 72 6 was be AUX dpc-4458 72 7 applied apply VERB dpc-4458 72 8 through through ADP dpc-4458 72 9 a a DET dpc-4458 72 10 straightforward straightforward ADJ dpc-4458 72 11 modification modification NOUN dpc-4458 72 12 of of ADP dpc-4458 72 13 the the DET dpc-4458 72 14 previously previously ADV dpc-4458 72 15 established establish VERB dpc-4458 72 16 weighted weight VERB dpc-4458 72 17 linear linear ADJ dpc-4458 72 18 regression regression NOUN dpc-4458 72 19 technique technique NOUN dpc-4458 72 20 . . PUNCT dpc-4458 73 1 this this DET dpc-4458 73 2 method method NOUN dpc-4458 73 3 was be AUX dpc-4458 73 4 specifically specifically ADV dpc-4458 73 5 utilized utilize VERB dpc-4458 73 6 to to PART dpc-4458 73 7 assess assess VERB dpc-4458 73 8 the the DET dpc-4458 73 9 robustness robustness NOUN dpc-4458 73 10 of of ADP dpc-4458 73 11 the the DET dpc-4458 73 12 mr mr PROPN dpc-4458 73 13 findings finding NOUN dpc-4458 73 14 as as ADP dpc-4458 73 15 a a DET dpc-4458 73 16 form form NOUN dpc-4458 73 17 of of ADP dpc-4458 73 18 validation validation NOUN dpc-4458 73 19 . . PUNCT dpc-4458 74 1 [ [ X dpc-4458 74 2 15 15 NUM dpc-4458 74 3 , , PUNCT dpc-4458 74 4 16 16 NUM dpc-4458 74 5 , , PUNCT dpc-4458 74 6 18 18 NUM dpc-4458 74 7 ] ] PUNCT dpc-4458 74 8 . . PUNCT dpc-4458 75 1 sensitivity sensitivity NOUN dpc-4458 75 2 analysis analysis NOUN dpc-4458 75 3 the the DET dpc-4458 75 4 heterogeneity heterogeneity NOUN dpc-4458 75 5 of of ADP dpc-4458 75 6 the the DET dpc-4458 75 7 chosen choose VERB dpc-4458 75 8 snps snps PROPN dpc-4458 75 9 was be AUX dpc-4458 75 10 evaluated evaluate VERB dpc-4458 75 11 using use VERB dpc-4458 75 12 cochran cochran NOUN dpc-4458 75 13 ’s ’s PART dpc-4458 75 14 q q PROPN dpc-4458 75 15 test test NOUN dpc-4458 75 16 ; ; PUNCT dpc-4458 75 17 a a DET dpc-4458 75 18 p p NOUN dpc-4458 75 19 - - PUNCT dpc-4458 75 20 value value NOUN dpc-4458 75 21 of of ADP dpc-4458 75 22 more more ADJ dpc-4458 75 23 than than ADP dpc-4458 75 24 0.05 0.05 NUM dpc-4458 75 25 suggested suggest VERB dpc-4458 75 26     SPACE dpc-4458 75 27 the the DET dpc-4458 75 28 lack lack NOUN dpc-4458 75 29 of of ADP dpc-4458 75 30 heterogeneity heterogeneity NOUN dpc-4458 75 31 . . PUNCT dpc-4458 76 1 the the DET dpc-4458 76 2 random random ADJ dpc-4458 76 3 effects effect NOUN dpc-4458 76 4 model model NOUN dpc-4458 76 5 was be AUX dpc-4458 76 6 used use VERB dpc-4458 76 7 once once ADV dpc-4458 76 8 significant significant ADJ dpc-4458 76 9 heterogeneity heterogeneity NOUN dpc-4458 76 10 had have AUX dpc-4458 76 11 been be AUX dpc-4458 76 12 identified identify VERB dpc-4458 76 13 . . PUNCT dpc-4458 77 1 we we PRON dpc-4458 77 2 evaluated evaluate VERB dpc-4458 77 3 the the DET dpc-4458 77 4 possible possible ADJ dpc-4458 77 5 bias bias NOUN dpc-4458 77 6 from from ADP dpc-4458 77 7 horizontal horizontal ADJ dpc-4458 77 8 pleiotropy pleiotropy NOUN dpc-4458 77 9 using use VERB dpc-4458 77 10 the the DET dpc-4458 77 11 weighted weight VERB dpc-4458 77 12 median median NOUN dpc-4458 77 13 and and CCONJ dpc-4458 77 14 mr mr PROPN dpc-4458 77 15 - - PUNCT dpc-4458 77 16 egger egger NOUN dpc-4458 77 17 regression regression NOUN dpc-4458 77 18 in in ADP dpc-4458 77 19 order order NOUN dpc-4458 77 20 to to PART dpc-4458 77 21 gauge gauge VERB dpc-4458 77 22 the the DET dpc-4458 77 23 robustness robustness NOUN dpc-4458 77 24 of of ADP dpc-4458 77 25 the the DET dpc-4458 77 26 ivw ivw NOUN dpc-4458 77 27 method method NOUN dpc-4458 77 28 . . PUNCT dpc-4458 78 1 the the DET dpc-4458 78 2 mr mr PROPN dpc-4458 78 3 - - PUNCT dpc-4458 78 4 presso presso NOUN dpc-4458 78 5 ( ( PUNCT dpc-4458 78 6 mendelian mendelian ADJ dpc-4458 78 7 randomization randomization NOUN dpc-4458 78 8 pleiotropy pleiotropy VERB dpc-4458 78 9 residual residual ADJ dpc-4458 78 10 sum sum NOUN dpc-4458 78 11 and and CCONJ dpc-4458 78 12 outlier outlier NOUN dpc-4458 78 13 ) ) PUNCT dpc-4458 78 14 test test NOUN dpc-4458 78 15 was be AUX dpc-4458 78 16 used use VERB dpc-4458 78 17 to to PART dpc-4458 78 18 identify identify VERB dpc-4458 78 19 outliers outlier NOUN dpc-4458 78 20 that that PRON dpc-4458 78 21 might might AUX dpc-4458 78 22 have have AUX dpc-4458 78 23 been be AUX dpc-4458 78 24 influenced influence VERB dpc-4458 78 25 by by ADP dpc-4458 78 26 horizontal horizontal ADJ dpc-4458 78 27 pleiotropy pleiotropy NOUN dpc-4458 78 28 . . PUNCT dpc-4458 79 1 the the DET dpc-4458 79 2 causal causal ADJ dpc-4458 79 3 effect effect NOUN dpc-4458 79 4 estimates estimate NOUN dpc-4458 79 5 for for ADP dpc-4458 79 6 individual individual ADJ dpc-4458 79 7 variants variant NOUN dpc-4458 79 8 were be AUX dpc-4458 79 9 displayed display VERB dpc-4458 79 10 using use VERB dpc-4458 79 11 a a DET dpc-4458 79 12 scatter scatter NOUN dpc-4458 79 13 plot plot NOUN dpc-4458 79 14 . . PUNCT dpc-4458 80 1 thereafter thereafter ADV dpc-4458 80 2 , , PUNCT dpc-4458 80 3 we we PRON dpc-4458 80 4 carried carry VERB dpc-4458 80 5 out out ADP dpc-4458 80 6     SPACE dpc-4458 80 7 a a DET dpc-4458 80 8 “ " PUNCT dpc-4458 80 9 leave leave VERB dpc-4458 80 10 - - PUNCT dpc-4458 80 11 one one NUM dpc-4458 80 12 - - PUNCT dpc-4458 80 13 out out NOUN dpc-4458 80 14 ” " PUNCT dpc-4458 80 15 to to PART dpc-4458 80 16 test test VERB dpc-4458 80 17 the the DET dpc-4458 80 18 robustness robustness NOUN dpc-4458 80 19 of of ADP dpc-4458 80 20 the the DET dpc-4458 80 21 results result NOUN dpc-4458 80 22 [ [ X dpc-4458 80 23 15 15 NUM dpc-4458 80 24 , , PUNCT dpc-4458 80 25 16 16 NUM dpc-4458 80 26 , , PUNCT dpc-4458 80 27 18 18 NUM dpc-4458 80 28 ] ] PUNCT dpc-4458 80 29 . . PUNCT dpc-4458 81 1 table table NOUN dpc-4458 81 2 1 1 NUM dpc-4458 81 3 . . PUNCT dpc-4458 82 1 gwas gwas PROPN dpc-4458 82 2 summary summary PROPN dpc-4458 82 3 data datum NOUN dpc-4458 82 4 sources source NOUN dpc-4458 82 5 included include VERB dpc-4458 82 6 in in ADP dpc-4458 82 7 the the DET dpc-4458 82 8 study study NOUN dpc-4458 82 9 . . PUNCT dpc-4458 83 1 diseases disease NOUN dpc-4458 83 2 gwas gwa VERB dpc-4458 83 3 i i PROPN dpc-4458 83 4 d d PROPN dpc-4458 83 5 n n PROPN dpc-4458 83 6 of of ADP dpc-4458 83 7 cases case NOUN dpc-4458 83 8 n n ADP dpc-4458 83 9 of of ADP dpc-4458 83 10 controls control NOUN dpc-4458 83 11 population population NOUN dpc-4458 83 12 n n ADP dpc-4458 83 13 of of ADP dpc-4458 83 14 snps snps PROPN dpc-4458 83 15 psoriasis psoriasis VERB dpc-4458 83 16 ebi ebi NOUN dpc-4458 83 17 - - PUNCT dpc-4458 83 18 a a DET dpc-4458 83 19 - - PUNCT dpc-4458 83 20 gcst90018907 gcst90018907 PROPN dpc-4458 83 21 5,072 5,072 NUM dpc-4458 83 22 478,102 478,102 NUM dpc-4458 83 23 european european ADJ dpc-4458 83 24 15 15 NUM dpc-4458 83 25 psoriasis psoriasis NOUN dpc-4458 83 26 ukb ukb ADJ dpc-4458 83 27 - - PUNCT dpc-4458 83 28 b-10537 b-10537 NOUN dpc-4458 83 29 5,314 5,314 NUM dpc-4458 83 30 457,619 457,619 NUM dpc-4458 83 31 european european ADJ dpc-4458 83 32 21 21 NUM dpc-4458 83 33 psoriasis psoriasis NOUN dpc-4458 83 34 finn finn PROPN dpc-4458 83 35 - - PUNCT dpc-4458 83 36 b b NOUN dpc-4458 83 37 - - PUNCT dpc-4458 83 38 l12_psori l12_psori X dpc-4458 83 39 _ _ NOUN dpc-4458 83 40 vulg vulg VERB dpc-4458 83 41 2,802 2,802 NUM dpc-4458 83 42 212,242 212,242 NUM dpc-4458 83 43 european european ADJ dpc-4458 83 44 10 10 NUM dpc-4458 83 45 bullous bullous ADJ dpc-4458 83 46 pemphigoid pemphigoid ADJ dpc-4458 83 47 finn finn PROPN dpc-4458 83 48 - - PUNCT dpc-4458 83 49 b b NOUN dpc-4458 83 50 - - PUNCT dpc-4458 83 51 l12 l12 NOUN dpc-4458 83 52 _ _ NOUN dpc-4458 83 53 pemphigoid_bull pemphigoid_bull NOUN dpc-4458 83 54 219 219 NUM dpc-4458 83 55 218,066 218,066 NUM dpc-4458 83 56 european european ADJ dpc-4458 83 57 14 14 NUM dpc-4458 83 58 abbreviations abbreviation NOUN dpc-4458 83 59 : : PUNCT dpc-4458 83 60 gwas gwas NOUN dpc-4458 83 61 : : PUNCT dpc-4458 83 62 genome genome NOUN dpc-4458 83 63 - - PUNCT dpc-4458 83 64 wide wide ADJ dpc-4458 83 65 association association NOUN dpc-4458 83 66 studies study NOUN dpc-4458 83 67 ; ; PUNCT dpc-4458 83 68 snps snps NOUN dpc-4458 83 69 : : PUNCT dpc-4458 83 70 single single ADJ dpc-4458 83 71 nucleotide nucleotide ADJ dpc-4458 83 72 polymorphisms polymorphism NOUN dpc-4458 83 73 . . PUNCT dpc-4458 84 1 figure figure NOUN dpc-4458 84 2 1 1 NUM dpc-4458 84 3 . . PUNCT dpc-4458 85 1 the the DET dpc-4458 85 2 flowchart flowchart NOUN dpc-4458 85 3 adhered adhere VERB dpc-4458 85 4 to to ADP dpc-4458 85 5 the the DET dpc-4458 85 6 principles principle NOUN dpc-4458 85 7 of of ADP dpc-4458 85 8 mr mr PROPN dpc-4458 85 9 analysis analysis NOUN dpc-4458 85 10 as as SCONJ dpc-4458 85 11 outlined outline VERB dpc-4458 85 12 in in ADP dpc-4458 85 13 this this DET dpc-4458 85 14 study study NOUN dpc-4458 85 15 . . PUNCT dpc-4458 86 1 4 4 NUM dpc-4458 86 2 original original ADJ dpc-4458 86 3 article article NOUN dpc-4458 86 4 | | ADV dpc-4458 86 5 dermatol dermatol ADJ dpc-4458 86 6 pract pract NOUN dpc-4458 86 7 concept concept NOUN dpc-4458 86 8 . . PUNCT dpc-4458 87 1 2025;15(1):4458 2025;15(1):4458 NUM dpc-4458 87 2 ( ( PUNCT dpc-4458 87 3 ebi ebi X dpc-4458 87 4 - - PUNCT dpc-4458 87 5 a a DET dpc-4458 87 6 - - PUNCT dpc-4458 87 7 gcst90018907 gcst90018907 PROPN dpc-4458 87 8 : : PUNCT dpc-4458 87 9 figure figure NOUN dpc-4458 87 10 2 2 NUM dpc-4458 87 11 ; ; PUNCT dpc-4458 87 12 ukb ukb PROPN dpc-4458 87 13 - - PUNCT dpc-4458 87 14 b-10537 b-10537 NOUN dpc-4458 87 15 : : PUNCT dpc-4458 87 16 figure figure NOUN dpc-4458 87 17 3 3 NUM dpc-4458 87 18 ; ; PUNCT dpc-4458 87 19 finn finn PROPN dpc-4458 87 20 - - PUNCT dpc-4458 87 21 b b NOUN dpc-4458 87 22 - - PUNCT dpc-4458 87 23 l12_psori_vulg l12_psori_vulg ADJ dpc-4458 87 24 : : PUNCT dpc-4458 87 25 table table NOUN dpc-4458 87 26 2 2 NUM dpc-4458 87 27 ) ) PUNCT dpc-4458 87 28 . . PUNCT dpc-4458 88 1 instead instead ADV dpc-4458 88 2 , , PUNCT dpc-4458 88 3 the the DET dpc-4458 88 4 reversed reverse VERB dpc-4458 88 5 mr mr PROPN dpc-4458 88 6 showed show VERB dpc-4458 88 7 that that SCONJ dpc-4458 88 8 bp bp PROPN dpc-4458 88 9 has have VERB dpc-4458 88 10 no no DET dpc-4458 88 11 causal causal ADJ dpc-4458 88 12 relationship relationship NOUN dpc-4458 88 13 with with ADP dpc-4458 88 14 the the DET dpc-4458 88 15 risk risk NOUN dpc-4458 88 16 of of ADP dpc-4458 88 17 psoriasis psoriasis NOUN dpc-4458 88 18 ( ( PUNCT dpc-4458 88 19 table table NOUN dpc-4458 88 20 3 3 NUM dpc-4458 88 21 ) ) PUNCT dpc-4458 88 22 . . PUNCT dpc-4458 89 1 using use VERB dpc-4458 89 2 the the DET dpc-4458 89 3 mr mr PROPN dpc-4458 89 4 - - PUNCT dpc-4458 89 5 egger egger NOUN dpc-4458 89 6 , , PUNCT dpc-4458 89 7 the the DET dpc-4458 89 8 relationships relationship NOUN dpc-4458 89 9 between between ADP dpc-4458 89 10 psoriasis psoriasis NOUN dpc-4458 89 11 and and CCONJ dpc-4458 89 12 bp bp PROPN dpc-4458 89 13 had have VERB dpc-4458 89 14 the the DET dpc-4458 89 15 same same ADJ dpc-4458 89 16 direction direction NOUN dpc-4458 89 17 ( ( PUNCT dpc-4458 89 18 figure figure NOUN dpc-4458 89 19 4a 4a NUM dpc-4458 89 20 – – PUNCT dpc-4458 89 21 c c NOUN dpc-4458 89 22 ) ) PUNCT dpc-4458 89 23 . . PUNCT dpc-4458 90 1 sensitivity sensitivity NOUN dpc-4458 90 2 analysis analysis NOUN dpc-4458 90 3 according accord VERB dpc-4458 90 4 to to ADP dpc-4458 90 5 the the DET dpc-4458 90 6 analysis analysis NOUN dpc-4458 90 7 of of ADP dpc-4458 90 8 cochran cochran NOUN dpc-4458 90 9 ’s ’s PART dpc-4458 90 10 q q PROPN dpc-4458 90 11 test test NOUN dpc-4458 90 12 , , PUNCT dpc-4458 90 13 our our PRON dpc-4458 90 14     SPACE dpc-4458 90 15 ivw ivw NOUN dpc-4458 90 16 - - PUNCT dpc-4458 90 17 mr mr NOUN dpc-4458 90 18 analysis analysis NOUN dpc-4458 90 19 results result NOUN dpc-4458 90 20 demonstrated demonstrate VERB dpc-4458 90 21 no no DET dpc-4458 90 22 evidence evidence NOUN dpc-4458 90 23 of of ADP dpc-4458 90 24 heterogeneity heterogeneity NOUN dpc-4458 90 25 among among ADP dpc-4458 90 26 the the DET dpc-4458 90 27 reported report VERB dpc-4458 90 28 results result NOUN dpc-4458 90 29 . . PUNCT dpc-4458 91 1 furthermore furthermore ADV dpc-4458 91 2 , , PUNCT dpc-4458 91 3 the the DET dpc-4458 91 4 mr mr PROPN dpc-4458 91 5 - - PUNCT dpc-4458 91 6 egger egger NOUN dpc-4458 91 7 regression regression NOUN dpc-4458 91 8 and and CCONJ dpc-4458 91 9 mr mr PROPN dpc-4458 91 10 - - PUNCT dpc-4458 91 11 presso presso NOUN dpc-4458 91 12 analysis analysis NOUN dpc-4458 91 13 results result NOUN dpc-4458 91 14 provided provide VERB dpc-4458 91 15 evidence evidence NOUN dpc-4458 91 16 that that SCONJ dpc-4458 91 17 there there PRON dpc-4458 91 18 exists exist VERB dpc-4458 91 19 no no DET dpc-4458 91 20 significant significant ADJ dpc-4458 91 21 horizontal horizontal ADJ dpc-4458 91 22 pleiotropy pleiotropy NOUN dpc-4458 91 23 in in ADP dpc-4458 91 24 our our PRON dpc-4458 91 25 mr mr PROPN dpc-4458 91 26 analysis analysis NOUN dpc-4458 91 27 ( ( PUNCT dpc-4458 91 28 table table NOUN dpc-4458 91 29 4 4 NUM dpc-4458 91 30 ) ) PUNCT dpc-4458 91 31 . . PUNCT dpc-4458 91 32     SPACE dpc-4458 92 1 the the DET dpc-4458 92 2 symmetric symmetric ADJ dpc-4458 92 3 funnel funnel NOUN dpc-4458 92 4 plot plot NOUN dpc-4458 92 5 ( ( PUNCT dpc-4458 92 6 figure figure NOUN dpc-4458 92 7     SPACE dpc-4458 92 8 s1 s1 NOUN dpc-4458 92 9 ) ) PUNCT dpc-4458 92 10 indicated indicate VERB dpc-4458 92 11 no no DET dpc-4458 92 12 evidence evidence NOUN dpc-4458 92 13 of of ADP dpc-4458 92 14 horizontal horizontal ADJ dpc-4458 92 15 pleiotropy pleiotropy NOUN dpc-4458 92 16 . . PUNCT dpc-4458 93 1 we we PRON dpc-4458 93 2 also also ADV dpc-4458 93 3 conducted conduct VERB dpc-4458 93 4 the the DET dpc-4458 93 5 leave leave VERB dpc-4458 93 6 - - PUNCT dpc-4458 93 7 one one NUM dpc-4458 93 8 - - PUNCT dpc-4458 93 9 out out NOUN dpc-4458 93 10 method method NOUN dpc-4458 93 11 to to PART dpc-4458 93 12 identify identify VERB dpc-4458 93 13 and and CCONJ dpc-4458 93 14 delete delete ADJ dpc-4458 93 15 abnormal abnormal ADJ dpc-4458 93 16 instrumental instrumental ADJ dpc-4458 93 17 variables variable NOUN dpc-4458 93 18 . . PUNCT dpc-4458 94 1 the the DET dpc-4458 94 2 results result NOUN dpc-4458 94 3 showed show VERB dpc-4458 94 4 the the DET dpc-4458 94 5 robustness robustness NOUN dpc-4458 94 6 of of ADP dpc-4458 94 7 our our PRON dpc-4458 94 8 results result NOUN dpc-4458 94 9 ( ( PUNCT dpc-4458 94 10 figure figure NOUN dpc-4458 94 11 s2 s2 PROPN dpc-4458 94 12 ) ) PUNCT dpc-4458 94 13 . . PUNCT dpc-4458 95 1 these these DET dpc-4458 95 2 results result NOUN dpc-4458 95 3 suggest suggest VERB dpc-4458 95 4 that that SCONJ dpc-4458 95 5 the the DET dpc-4458 95 6 mr mr PROPN dpc-4458 95 7 analysis analysis NOUN dpc-4458 95 8 results result NOUN dpc-4458 95 9 were be AUX dpc-4458 95 10 relatively relatively ADV dpc-4458 95 11 stable stable ADJ dpc-4458 95 12 . . PUNCT dpc-4458 96 1 statistical statistical ADJ dpc-4458 96 2 analysis analysis NOUN dpc-4458 96 3 all all DET dpc-4458 96 4 data datum NOUN dpc-4458 96 5 were be AUX dpc-4458 96 6 analyzed analyze VERB dpc-4458 96 7 by by ADP dpc-4458 96 8 r r NOUN dpc-4458 96 9 software software NOUN dpc-4458 96 10 ( ( PUNCT dpc-4458 96 11 version version NOUN dpc-4458 96 12 4.3.2 4.3.2 NOUN dpc-4458 96 13 ) ) PUNCT dpc-4458 96 14 , , PUNCT dpc-4458 96 15 “ " PUNCT dpc-4458 96 16 two two NUM dpc-4458 96 17 - - PUNCT dpc-4458 96 18 sample sample NOUN dpc-4458 96 19 mr mr PROPN dpc-4458 96 20 package package PROPN dpc-4458 96 21 ” " PUNCT dpc-4458 96 22 ( ( PUNCT dpc-4458 96 23 version version NOUN dpc-4458 96 24 0.5.8 0.5.8 NUM dpc-4458 96 25 ) ) PUNCT dpc-4458 96 26 . . PUNCT dpc-4458 97 1 the the DET dpc-4458 97 2 statistical statistical ADJ dpc-4458 97 3 significance significance NOUN dpc-4458 97 4 level level NOUN dpc-4458 97 5 is be AUX dpc-4458 97 6 p p NOUN dpc-4458 97 7 < < NOUN dpc-4458 97 8 0.05 0.05 NUM dpc-4458 97 9 . . PUNCT dpc-4458 98 1 pooled pool VERB dpc-4458 98 2 odds odd NOUN dpc-4458 98 3 ratios ratio NOUN dpc-4458 98 4 ( ( PUNCT dpc-4458 98 5 ors or NOUN dpc-4458 98 6 ) ) PUNCT dpc-4458 98 7 with with ADP dpc-4458 98 8 95 95 NUM dpc-4458 98 9 % % NOUN dpc-4458 98 10 confidence confidence NOUN dpc-4458 98 11 intervals interval NOUN dpc-4458 98 12 ( ( PUNCT dpc-4458 98 13 ci ci NOUN dpc-4458 98 14 ) ) PUNCT dpc-4458 98 15 were be AUX dpc-4458 98 16 calculated calculate VERB dpc-4458 98 17 . . PUNCT dpc-4458 99 1 results result VERB dpc-4458 99 2 instrumental instrumental ADJ dpc-4458 99 3 variables variable NOUN dpc-4458 99 4 according accord VERB dpc-4458 99 5 to to ADP dpc-4458 99 6 the the DET dpc-4458 99 7 quality quality NOUN dpc-4458 99 8 control control NOUN dpc-4458 99 9 principle principle NOUN dpc-4458 99 10 as as SCONJ dpc-4458 99 11 mentioned mention VERB dpc-4458 99 12 , , PUNCT dpc-4458 99 13 snps snps PROPN dpc-4458 99 14 related relate VERB dpc-4458 99 15 to to ADP dpc-4458 99 16 psoriasis psoriasis NOUN dpc-4458 99 17 and and CCONJ dpc-4458 99 18 bp bp PROPN dpc-4458 99 19     SPACE dpc-4458 99 20 were be AUX dpc-4458 99 21 adopted adopt VERB dpc-4458 99 22 as as ADP dpc-4458 99 23 instrumental instrumental ADJ dpc-4458 99 24 variables variable NOUN dpc-4458 99 25 ( ( PUNCT dpc-4458 99 26 ivs ivs NOUN dpc-4458 99 27 ) ) PUNCT dpc-4458 99 28 . . PUNCT dpc-4458 100 1 table table NOUN dpc-4458 100 2 1 1 NUM dpc-4458 100 3 shows show VERB dpc-4458 100 4 the the DET dpc-4458 100 5 essential essential ADJ dpc-4458 100 6 information information NOUN dpc-4458 100 7 regarding regard VERB dpc-4458 100 8 psoriasis psoriasis NOUN dpc-4458 100 9 and and CCONJ dpc-4458 100 10 bp bp PROPN dpc-4458 100 11 . . PUNCT dpc-4458 101 1 the the DET dpc-4458 101 2 snps snps PROPN dpc-4458 101 3 included include VERB dpc-4458 101 4 in in ADP dpc-4458 101 5 the the DET dpc-4458 101 6 exposure exposure NOUN dpc-4458 101 7 data datum NOUN dpc-4458 101 8 are be AUX dpc-4458 101 9 detailed detail VERB dpc-4458 101 10 in in ADP dpc-4458 101 11 supplementary supplementary ADJ dpc-4458 101 12 table table NOUN dpc-4458 101 13 s2 s2 PROPN dpc-4458 101 14 . . PUNCT dpc-4458 102 1 mr mr PROPN dpc-4458 102 2 analysis analysis NOUN dpc-4458 102 3 we we PRON dpc-4458 102 4 conducted conduct VERB dpc-4458 102 5 a a DET dpc-4458 102 6 two two NUM dpc-4458 102 7 - - PUNCT dpc-4458 102 8 sample sample NOUN dpc-4458 102 9 mr mr PROPN dpc-4458 102 10 analysis analysis NOUN dpc-4458 102 11 between between ADP dpc-4458 102 12 psoriasis psoriasis NOUN dpc-4458 102 13 and and CCONJ dpc-4458 102 14 bp bp PROPN dpc-4458 102 15 . . PUNCT dpc-4458 103 1 the the DET dpc-4458 103 2 ivw ivw NOUN dpc-4458 103 3 mr mr PROPN dpc-4458 103 4 analysis analysis NOUN dpc-4458 103 5 demonstrated demonstrate VERB dpc-4458 103 6 that that SCONJ dpc-4458 103 7     SPACE dpc-4458 103 8 psoriasis psoriasis NOUN dpc-4458 103 9 has have VERB dpc-4458 103 10 a a DET dpc-4458 103 11 causal causal ADJ dpc-4458 103 12 relationship relationship NOUN dpc-4458 103 13 with with ADP dpc-4458 103 14 the the DET dpc-4458 103 15 risk risk NOUN dpc-4458 103 16 of of ADP dpc-4458 103 17 bp bp PROPN dpc-4458 103 18 figure figure NOUN dpc-4458 103 19 2 2 NUM dpc-4458 103 20 . . PUNCT dpc-4458 103 21 forest forest NOUN dpc-4458 103 22 plot plot NOUN dpc-4458 103 23 of of ADP dpc-4458 103 24 mendelian mendelian ADJ dpc-4458 103 25 randomization randomization NOUN dpc-4458 103 26 analysis analysis NOUN dpc-4458 103 27 for for ADP dpc-4458 103 28 psoriasis psoriasis NOUN dpc-4458 103 29 ( ( PUNCT dpc-4458 103 30 ebi ebi X dpc-4458 103 31 - - PUNCT dpc-4458 103 32 a a DET dpc-4458 103 33 - - PUNCT dpc-4458 103 34 gcst90018907 gcst90018907 PROPN dpc-4458 103 35 ) ) PUNCT dpc-4458 103 36 on on ADP dpc-4458 103 37 bp bp PROPN dpc-4458 103 38 risk risk NOUN dpc-4458 103 39 . . PUNCT dpc-4458 104 1 abbreviations abbreviation NOUN dpc-4458 104 2 : : PUNCT dpc-4458 104 3 ci ci NOUN dpc-4458 104 4 : : PUNCT dpc-4458 104 5 confidence confidence NOUN dpc-4458 104 6 interval interval NOUN dpc-4458 104 7 ; ; PUNCT dpc-4458 104 8 or or CCONJ dpc-4458 104 9 : : PUNCT dpc-4458 104 10 odds odd NOUN dpc-4458 104 11 ratio ratio NOUN dpc-4458 104 12 . . PUNCT dpc-4458 105 1 figure figure NOUN dpc-4458 105 2 3 3 NUM dpc-4458 105 3 . . PUNCT dpc-4458 105 4 forest forest NOUN dpc-4458 105 5 plot plot NOUN dpc-4458 105 6 of of ADP dpc-4458 105 7 mendelian mendelian ADJ dpc-4458 105 8 randomization randomization NOUN dpc-4458 105 9 analysis analysis NOUN dpc-4458 105 10 for for ADP dpc-4458 105 11 psoriasis psoriasis NOUN dpc-4458 105 12 ( ( PUNCT dpc-4458 105 13 finn finn PROPN dpc-4458 105 14 - - PUNCT dpc-4458 105 15 b b NOUN dpc-4458 105 16 - - PUNCT dpc-4458 105 17 l12_psori_vulg l12_psori_vulg NOUN dpc-4458 105 18 ) ) PUNCT dpc-4458 105 19 on on ADP dpc-4458 105 20 bp bp PROPN dpc-4458 105 21 risk risk NOUN dpc-4458 105 22 . . PUNCT dpc-4458 106 1 abbreviations abbreviation NOUN dpc-4458 106 2 : : PUNCT dpc-4458 106 3 ci ci NOUN dpc-4458 106 4 : : PUNCT dpc-4458 106 5 confidence confidence NOUN dpc-4458 106 6 interval interval NOUN dpc-4458 106 7 ; ; PUNCT dpc-4458 106 8 or or CCONJ dpc-4458 106 9 : : PUNCT dpc-4458 106 10 odds odd NOUN dpc-4458 106 11 ratio ratio NOUN dpc-4458 106 12 . . PUNCT dpc-4458 107 1 original original ADJ dpc-4458 107 2 article article NOUN dpc-4458 107 3 | | ADV dpc-4458 107 4 dermatol dermatol ADJ dpc-4458 107 5 pract pract NOUN dpc-4458 107 6 concept concept NOUN dpc-4458 107 7 . . PUNCT dpc-4458 108 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 108 2 5 5 NUM dpc-4458 108 3 is be AUX dpc-4458 108 4 reported report VERB dpc-4458 108 5 that that SCONJ dpc-4458 108 6 psoriasis psoriasis NOUN dpc-4458 108 7 leads lead VERB dpc-4458 108 8 to to ADP dpc-4458 108 9 an an DET dpc-4458 108 10 increased increase VERB dpc-4458 108 11 risk risk NOUN dpc-4458 108 12 of of ADP dpc-4458 108 13 the the DET dpc-4458 108 14 pathosis pathosis NOUN dpc-4458 108 15 of of ADP dpc-4458 108 16 other other ADJ dpc-4458 108 17 organ organ NOUN dpc-4458 108 18 systems system NOUN dpc-4458 108 19 , , PUNCT dpc-4458 108 20 for for ADP dpc-4458 108 21 example example NOUN dpc-4458 108 22 , , PUNCT dpc-4458 108 23 cardiovascular cardiovascular ADJ dpc-4458 108 24 disease disease NOUN dpc-4458 108 25 , , PUNCT dpc-4458 108 26 psoriatic psoriatic ADJ dpc-4458 108 27 arthritis arthritis NOUN dpc-4458 108 28 , , PUNCT dpc-4458 108 29 obesity obesity NOUN dpc-4458 108 30 , , PUNCT dpc-4458 108 31 diabetes diabetes NOUN dpc-4458 108 32 mellitus mellitus NOUN dpc-4458 108 33 , , PUNCT dpc-4458 108 34 nonalcoholic nonalcoholic ADJ dpc-4458 108 35 fatty fatty NOUN dpc-4458 108 36 liver liver NOUN dpc-4458 108 37 disease disease NOUN dpc-4458 108 38 , , PUNCT dpc-4458 108 39 and and CCONJ dpc-4458 108 40 inflammatory inflammatory ADJ dpc-4458 108 41 bowel bowel NOUN dpc-4458 108 42 disease disease NOUN dpc-4458 108 43 , , PUNCT dpc-4458 108 44 compared compare VERB dpc-4458 108 45 with with ADP dpc-4458 108 46 that that PRON dpc-4458 108 47 of of ADP dpc-4458 108 48 the the DET dpc-4458 108 49 general general ADJ dpc-4458 108 50 population population NOUN dpc-4458 109 1 [ [ X dpc-4458 109 2 27 27 NUM dpc-4458 109 3 ] ] PUNCT dpc-4458 109 4 . . PUNCT dpc-4458 110 1 bullous bullous ADJ dpc-4458 110 2 pemphigoid pemphigoid NOUN dpc-4458 110 3 is be AUX dpc-4458 110 4 characterized characterize VERB dpc-4458 110 5 by by ADP dpc-4458 110 6 local local ADJ dpc-4458 110 7 inflammation inflammation NOUN dpc-4458 110 8 and and CCONJ dpc-4458 110 9 dermal dermal ADJ dpc-4458 110 10 - - PUNCT dpc-4458 110 11 epidermal epidermal ADJ dpc-4458 110 12 separation separation NOUN dpc-4458 110 13 and and CCONJ dpc-4458 110 14 belongs belong VERB dpc-4458 110 15 to to ADP dpc-4458 110 16 autoantibody autoantibody ADJ dpc-4458 110 17 - - PUNCT dpc-4458 110 18 mediated mediate VERB dpc-4458 110 19 blistering blistering ADJ dpc-4458 110 20 skin skin NOUN dpc-4458 110 21 disease disease NOUN dpc-4458 110 22 , , PUNCT dpc-4458 110 23 with with ADP dpc-4458 110 24 no no DET dpc-4458 110 25 approved approve VERB dpc-4458 110 26 targeted target VERB dpc-4458 110 27 therapy therapy NOUN dpc-4458 110 28 [ [ X dpc-4458 110 29 28 28 NUM dpc-4458 110 30 ] ] PUNCT dpc-4458 110 31 . . PUNCT dpc-4458 111 1 immunoprecipitation immunoprecipitation NOUN dpc-4458 111 2 with with ADP dpc-4458 111 3 bp bp PROPN dpc-4458 111 4 sera sera NOUN dpc-4458 111 5 of of ADP dpc-4458 111 6 extracts extract NOUN dpc-4458 111 7 of of ADP dpc-4458 111 8 cultured cultured ADJ dpc-4458 111 9 keratinocytes keratinocyte NOUN dpc-4458 111 10 identified identify VERB dpc-4458 111 11 two two NUM dpc-4458 111 12 hemidesmosomal hemidesmosomal ADJ dpc-4458 111 13 proteins protein NOUN dpc-4458 111 14 — — PUNCT dpc-4458 111 15 bp180 bp180 PROPN dpc-4458 111 16 ( ( PUNCT dpc-4458 111 17 180 180 NUM dpc-4458 111 18 kda kda NOUN dpc-4458 111 19 ) ) PUNCT dpc-4458 111 20 and and CCONJ dpc-4458 111 21 bp230 bp230 X dpc-4458 111 22 ( ( PUNCT dpc-4458 111 23 230 230 NUM dpc-4458 111 24 kda kda NOUN dpc-4458 111 25 ) ) PUNCT dpc-4458 112 1 [ [ X dpc-4458 112 2 29 29 NUM dpc-4458 112 3 , , PUNCT dpc-4458 112 4 30]—both 30]—both NUM dpc-4458 112 5 of of ADP dpc-4458 112 6 which which PRON dpc-4458 112 7 have have AUX dpc-4458 112 8 been be AUX dpc-4458 112 9 identified identify VERB dpc-4458 112 10 as as ADP dpc-4458 112 11 target target NOUN dpc-4458 112 12 antigens antigen NOUN dpc-4458 112 13 in in ADP dpc-4458 112 14 bp bp PROPN dpc-4458 112 15 . . PUNCT dpc-4458 113 1 pathologically pathologically ADV dpc-4458 113 2 , , PUNCT dpc-4458 113 3 bp180 bp180 PROPN dpc-4458 113 4 leads lead VERB dpc-4458 113 5 to to ADP dpc-4458 113 6 the the DET dpc-4458 113 7 release release NOUN dpc-4458 113 8 of of ADP dpc-4458 113 9 il-6 il-6 NOUN dpc-4458 113 10 and and CCONJ dpc-4458 113 11 il-8 il-8 NOUN dpc-4458 114 1 [ [ X dpc-4458 114 2 31 31 NUM dpc-4458 114 3 ] ] PUNCT dpc-4458 114 4 . . PUNCT dpc-4458 115 1 as as SCONJ dpc-4458 115 2 mentioned mention VERB dpc-4458 115 3 , , PUNCT dpc-4458 115 4 psoriasis psoriasis NOUN dpc-4458 115 5 and and CCONJ dpc-4458 115 6 bp bp PROPN dpc-4458 115 7 are be AUX dpc-4458 115 8 both both PRON dpc-4458 115 9 skin skin NOUN dpc-4458 115 10 diseases disease NOUN dpc-4458 115 11 seen see VERB dpc-4458 115 12 in in ADP dpc-4458 115 13 clinical clinical ADJ dpc-4458 115 14 practice practice NOUN dpc-4458 115 15 . . PUNCT dpc-4458 116 1 our our PRON dpc-4458 116 2 mr mr PROPN dpc-4458 116 3 study study NOUN dpc-4458 116 4 results result NOUN dpc-4458 116 5 suggest suggest VERB dpc-4458 116 6 psoriasis psoriasis NOUN dpc-4458 116 7 itself itself PRON dpc-4458 116 8 might might AUX dpc-4458 116 9 cause cause VERB dpc-4458 116 10 bp bp PROPN dpc-4458 116 11 . . PUNCT dpc-4458 117 1 previous previous ADJ dpc-4458 117 2 case case NOUN dpc-4458 117 3 - - PUNCT dpc-4458 117 4 control control NOUN dpc-4458 117 5 studies study NOUN dpc-4458 117 6 showed show VERB dpc-4458 117 7 similar similar ADJ dpc-4458 117 8 results result NOUN dpc-4458 117 9 [ [ X dpc-4458 117 10 12 12 NUM dpc-4458 117 11 , , PUNCT dpc-4458 117 12 32 32 NUM dpc-4458 117 13 ] ] PUNCT dpc-4458 117 14 . . PUNCT dpc-4458 118 1 according accord VERB dpc-4458 118 2 to to ADP dpc-4458 118 3 a a DET dpc-4458 118 4 largescale largescale ADJ dpc-4458 118 5 population population NOUN dpc-4458 118 6 - - PUNCT dpc-4458 118 7 based base VERB dpc-4458 118 8 cohort cohort NOUN dpc-4458 118 9 study study NOUN dpc-4458 118 10 , , PUNCT dpc-4458 118 11 patients patient NOUN dpc-4458 118 12 with with ADP dpc-4458 118 13 psoriasis psoriasis NOUN dpc-4458 118 14 were be AUX dpc-4458 118 15 statistically statistically ADV dpc-4458 118 16 independently independently ADV dpc-4458 118 17 associated associate VERB dpc-4458 118 18 with with ADP dpc-4458 118 19 a a DET dpc-4458 118 20 threefold threefold ADJ dpc-4458 118 21 discussion discussion NOUN dpc-4458 118 22 our our PRON dpc-4458 118 23 results result NOUN dpc-4458 118 24 revealed reveal VERB dpc-4458 118 25 psoriasis psoriasis NOUN dpc-4458 118 26 itself itself PRON dpc-4458 118 27 is be AUX dpc-4458 118 28 an an DET dpc-4458 118 29 independent independent ADJ dpc-4458 118 30 causal causal ADJ dpc-4458 118 31 factor factor NOUN dpc-4458 118 32 of of ADP dpc-4458 118 33 bp bp PROPN dpc-4458 118 34 . . PUNCT dpc-4458 119 1 in in ADP dpc-4458 119 2 addition addition NOUN dpc-4458 119 3 , , PUNCT dpc-4458 119 4 the the DET dpc-4458 119 5 sensitivity sensitivity NOUN dpc-4458 119 6 analysis analysis NOUN dpc-4458 119 7 supported support VERB dpc-4458 119 8     SPACE dpc-4458 119 9 the the DET dpc-4458 119 10 validity validity NOUN dpc-4458 119 11 of of ADP dpc-4458 119 12 the the DET dpc-4458 119 13 results result NOUN dpc-4458 119 14 . . PUNCT dpc-4458 120 1 in in ADP dpc-4458 120 2 contrast contrast NOUN dpc-4458 120 3 , , PUNCT dpc-4458 120 4 our our PRON dpc-4458 120 5 reverse reverse NOUN dpc-4458 120 6 mr mr PROPN dpc-4458 120 7 analysis analysis NOUN dpc-4458 120 8 showed show VERB dpc-4458 120 9 that that SCONJ dpc-4458 120 10 bp bp PROPN dpc-4458 120 11 was be AUX dpc-4458 120 12 not not PART dpc-4458 120 13 significantly significantly ADV dpc-4458 120 14 associated associate VERB dpc-4458 120 15 with with ADP dpc-4458 120 16 psoriasis psoriasis NOUN dpc-4458 120 17 progression progression NOUN dpc-4458 120 18 . . PUNCT dpc-4458 121 1 psoriasis psoriasis NOUN dpc-4458 121 2 is be AUX dpc-4458 121 3 recognized recognize VERB dpc-4458 121 4 as as ADP dpc-4458 121 5 a a DET dpc-4458 121 6 systemic systemic ADJ dpc-4458 121 7 autoimmune autoimmune ADJ dpc-4458 121 8 disorder disorder NOUN dpc-4458 121 9 , , PUNCT dpc-4458 121 10 with with SCONJ dpc-4458 121 11 its its PRON dpc-4458 121 12 etiology etiology NOUN dpc-4458 121 13 attributed attribute VERB dpc-4458 121 14 to to ADP dpc-4458 121 15 a a DET dpc-4458 121 16 combination combination NOUN dpc-4458 121 17 of of ADP dpc-4458 121 18 environmental environmental ADJ dpc-4458 121 19 factors factor NOUN dpc-4458 121 20 , , PUNCT dpc-4458 121 21 immune immune ADJ dpc-4458 121 22 dysregulation dysregulation NOUN dpc-4458 121 23 , , PUNCT dpc-4458 121 24 and and CCONJ dpc-4458 121 25 genetic genetic ADJ dpc-4458 121 26 predisposition predisposition NOUN dpc-4458 121 27 . . PUNCT dpc-4458 122 1 [ [ X dpc-4458 122 2 19 19 NUM dpc-4458 122 3 ] ] PUNCT dpc-4458 122 4 . . PUNCT dpc-4458 123 1 the the DET dpc-4458 123 2 pathogenesis pathogenesis NOUN dpc-4458 123 3 progression progression NOUN dpc-4458 123 4 of of ADP dpc-4458 123 5 psoriasis psoriasis NOUN dpc-4458 123 6 has have AUX dpc-4458 123 7 gradually gradually ADV dpc-4458 123 8 been be AUX dpc-4458 123 9 expounded expound VERB dpc-4458 123 10 : : PUNCT dpc-4458 123 11 extracellular extracellular ADJ dpc-4458 123 12 cytokine cytokine NOUN dpc-4458 123 13 pathways pathway NOUN dpc-4458 123 14 and and CCONJ dpc-4458 123 15 intracellular intracellular ADJ dpc-4458 123 16 signaling signal VERB dpc-4458 123 17 molecules molecule NOUN dpc-4458 123 18 take take VERB dpc-4458 123 19 part part NOUN dpc-4458 123 20 in in ADP dpc-4458 123 21 the the DET dpc-4458 123 22 progression progression NOUN dpc-4458 123 23 of of ADP dpc-4458 123 24 psoriasis psoriasis NOUN dpc-4458 123 25 , , PUNCT dpc-4458 123 26 collectively collectively ADV dpc-4458 124 1 [ [ X dpc-4458 124 2 20 20 NUM dpc-4458 124 3 ] ] PUNCT dpc-4458 124 4 . . PUNCT dpc-4458 125 1 extracellular extracellular ADJ dpc-4458 125 2 cytokine cytokine NOUN dpc-4458 125 3 pathways pathway NOUN dpc-4458 125 4 mainly mainly ADV dpc-4458 125 5 included include VERB dpc-4458 125 6 the the DET dpc-4458 125 7 tumor tumor NOUN dpc-4458 125 8 necrosis necrosis NOUN dpc-4458 125 9 factor factor NOUN dpc-4458 125 10 ( ( PUNCT dpc-4458 125 11 tnf)/ tnf)/ VERB dpc-4458 125 12 interleukin interleukin NOUN dpc-4458 125 13 ( ( PUNCT dpc-4458 125 14 il)-23 il)-23 NOUN dpc-4458 125 15 / / SYM dpc-4458 125 16 il-17 il-17 NUM dpc-4458 125 17 pathways pathway NOUN dpc-4458 126 1 [ [ X dpc-4458 126 2 21 21 NUM dpc-4458 126 3 - - SYM dpc-4458 126 4 23 23 NUM dpc-4458 126 5 ] ] PUNCT dpc-4458 126 6 ; ; PUNCT dpc-4458 126 7 intracellular intracellular ADJ dpc-4458 126 8 signaling signal VERB dpc-4458 126 9 pathways pathway NOUN dpc-4458 126 10 of of ADP dpc-4458 126 11 transmission transmission NOUN dpc-4458 126 12 mainly mainly ADV dpc-4458 126 13 included include VERB dpc-4458 126 14 the the DET dpc-4458 126 15 nuclear nuclear ADJ dpc-4458 126 16 factor factor NOUN dpc-4458 126 17 kappa kappa PROPN dpc-4458 126 18 b b PROPN dpc-4458 126 19 ( ( PUNCT dpc-4458 126 20 nf nf NOUN dpc-4458 126 21 - - PUNCT dpc-4458 126 22 κb κb NOUN dpc-4458 126 23 ) ) PUNCT dpc-4458 127 1 [ [ X dpc-4458 127 2 24 24 NUM dpc-4458 127 3 ] ] PUNCT dpc-4458 127 4 , , PUNCT dpc-4458 127 5 janus janus PROPN dpc-4458 127 6 kinase kinase PROPN dpc-4458 127 7 / / SYM dpc-4458 127 8 signal signal NOUN dpc-4458 127 9 transducer transducer NOUN dpc-4458 127 10 and and CCONJ dpc-4458 127 11 activator activator NOUN dpc-4458 127 12 ( ( PUNCT dpc-4458 127 13 jak jak NOUN dpc-4458 127 14 - - PUNCT dpc-4458 127 15 stat stat NOUN dpc-4458 127 16 ) ) PUNCT dpc-4458 128 1 [ [ X dpc-4458 128 2 25 25 NUM dpc-4458 128 3 ] ] PUNCT dpc-4458 128 4 , , PUNCT dpc-4458 128 5 and and CCONJ dpc-4458 128 6 mitogen mitogen NOUN dpc-4458 128 7 - - PUNCT dpc-4458 128 8 activated activate VERB dpc-4458 128 9 protein protein NOUN dpc-4458 128 10 kinases kinase NOUN dpc-4458 128 11 ( ( PUNCT dpc-4458 128 12 mapk mapk NOUN dpc-4458 128 13 ) ) PUNCT dpc-4458 128 14 pathway pathway NOUN dpc-4458 129 1 [ [ X dpc-4458 129 2 26 26 NUM dpc-4458 129 3 ] ] PUNCT dpc-4458 129 4 . . PUNCT dpc-4458 130 1 it it PRON dpc-4458 130 2 table table VERB dpc-4458 130 3 2 2 NUM dpc-4458 130 4 . . PUNCT dpc-4458 130 5 causal causal ADJ dpc-4458 130 6 association association NOUN dpc-4458 130 7 of of ADP dpc-4458 130 8 psoriasis psoriasis NOUN dpc-4458 130 9 ( ( PUNCT dpc-4458 130 10 ukb ukb ADJ dpc-4458 130 11 - - PUNCT dpc-4458 130 12 b-10537 b-10537 NOUN dpc-4458 130 13 ) ) PUNCT dpc-4458 130 14 on on ADP dpc-4458 130 15 bp bp PROPN dpc-4458 130 16 . . PUNCT dpc-4458 131 1 methods method NOUN dpc-4458 131 2 or or CCONJ dpc-4458 131 3 95 95 NUM dpc-4458 131 4 % % NOUN dpc-4458 131 5 ci ci NOUN dpc-4458 131 6 p p ADJ dpc-4458 131 7 - - PUNCT dpc-4458 131 8 value value NOUN dpc-4458 131 9 inverse inverse NOUN dpc-4458 131 10 - - PUNCT dpc-4458 131 11 variance variance NOUN dpc-4458 131 12 weighted weight VERB dpc-4458 131 13 1.201e+07 1.201e+07 NUM dpc-4458 131 14 9.066 9.066 NUM dpc-4458 131 15 - - PUNCT dpc-4458 131 16 1.590e+13 1.590e+13 NUM dpc-4458 131 17 0.023 0.023 NUM dpc-4458 131 18 mr mr PROPN dpc-4458 131 19 - - PUNCT dpc-4458 131 20 egger egger NOUN dpc-4458 131 21 1.239e+03 1.239e+03 NOUN dpc-4458 131 22 1.200e-5 1.200e-5 NUM dpc-4458 131 23 - - PUNCT dpc-4458 131 24 1.281e+11 1.281e+11 NUM dpc-4458 131 25 0.459 0.459 NUM dpc-4458 131 26 weighted weight VERB dpc-4458 131 27 median median ADJ dpc-4458 131 28 1.757e+04 1.757e+04 PROPN dpc-4458 131 29 3.269e-4 3.269e-4 PROPN dpc-4458 131 30 - - SYM dpc-4458 131 31 9.445e+11 9.445e+11 NUM dpc-4458 131 32 0.282 0.282 NUM dpc-4458 131 33 simple simple ADJ dpc-4458 131 34 mode mode NOUN dpc-4458 131 35 1.340e+22 1.340e+22 NUM dpc-4458 131 36 8.637 8.637 NUM dpc-4458 131 37 - - SYM dpc-4458 131 38 2.070e+43 2.070e+43 NUM dpc-4458 131 39 0.055 0.055 NUM dpc-4458 131 40 weighted weight VERB dpc-4458 131 41 mode mode NOUN dpc-4458 131 42 4.542e+03 4.542e+03 NUM dpc-4458 131 43 0.001 0.001 NUM dpc-4458 131 44 - - PUNCT dpc-4458 131 45 1.824e+11 1.824e+11 NUM dpc-4458 131 46 0.358 0.358 NUM dpc-4458 131 47 abbreviations abbreviation NOUN dpc-4458 131 48 : : PUNCT dpc-4458 131 49 bp bp PROPN dpc-4458 131 50 : : PUNCT dpc-4458 131 51 bullous bullous ADJ dpc-4458 131 52 pemphigoid pemphigoid NOUN dpc-4458 131 53 ; ; PUNCT dpc-4458 131 54 ci ci NOUN dpc-4458 131 55 : : PUNCT dpc-4458 131 56 confidence confidence NOUN dpc-4458 131 57 interval interval NOUN dpc-4458 131 58 ; ; PUNCT dpc-4458 131 59 mr mr PROPN dpc-4458 131 60 : : PUNCT dpc-4458 131 61 mendelian mendelian ADJ dpc-4458 131 62 randomization randomization NOUN dpc-4458 131 63 ; ; PUNCT dpc-4458 131 64 or or CCONJ dpc-4458 131 65 : : PUNCT dpc-4458 131 66 odds odd NOUN dpc-4458 131 67 ratio ratio NOUN dpc-4458 131 68 . . PUNCT dpc-4458 132 1 table table NOUN dpc-4458 132 2 3 3 NUM dpc-4458 132 3 . . PUNCT dpc-4458 132 4 reverse reverse ADJ dpc-4458 132 5 causality causality NOUN dpc-4458 132 6 between between ADP dpc-4458 132 7 bp bp PROPN dpc-4458 132 8 and and CCONJ dpc-4458 132 9 psoriasis psoriasis NOUN dpc-4458 132 10 . . PUNCT dpc-4458 133 1 bp bp PROPN dpc-4458 133 2 psoriasis psoriasis NOUN dpc-4458 134 1 i i NOUN dpc-4458 134 2 d d PROPN dpc-4458 134 3 methods method VERB dpc-4458 134 4 p p NOUN dpc-4458 134 5 - - PUNCT dpc-4458 134 6 value value NOUN dpc-4458 134 7 bp bp PROPN dpc-4458 134 8 ebi ebi PROPN dpc-4458 134 9 - - PUNCT dpc-4458 134 10 a a DET dpc-4458 134 11 - - PUNCT dpc-4458 134 12 gcst90018907 gcst90018907 PROPN dpc-4458 134 13 inverse inverse NOUN dpc-4458 134 14 - - PUNCT dpc-4458 134 15 variance variance NOUN dpc-4458 134 16 weighted weight VERB dpc-4458 134 17 0.181 0.181 NUM dpc-4458 134 18 mr mr PROPN dpc-4458 134 19 - - PUNCT dpc-4458 134 20 egger egger NOUN dpc-4458 134 21 0.722 0.722 NUM dpc-4458 134 22 weighted weight VERB dpc-4458 134 23 median median PROPN dpc-4458 134 24 0.765 0.765 NUM dpc-4458 134 25 simple simple ADJ dpc-4458 134 26 mode mode NOUN dpc-4458 134 27 0.776 0.776 NUM dpc-4458 134 28 weighted weight VERB dpc-4458 134 29 mode mode NOUN dpc-4458 134 30 0.891 0.891 NUM dpc-4458 134 31 bp bp PROPN dpc-4458 134 32 ukb ukb PROPN dpc-4458 134 33 - - PUNCT dpc-4458 134 34 b-10537 b-10537 ADJ dpc-4458 134 35 inverse inverse NOUN dpc-4458 134 36 variance variance NOUN dpc-4458 134 37 weighted weight VERB dpc-4458 134 38 0.870 0.870 NUM dpc-4458 134 39 mr mr NOUN dpc-4458 134 40 - - PUNCT dpc-4458 134 41 egger egger NOUN dpc-4458 134 42 0.631 0.631 NUM dpc-4458 134 43 weighted weight VERB dpc-4458 134 44 median median NOUN dpc-4458 134 45 0.117 0.117 NUM dpc-4458 134 46 simple simple ADJ dpc-4458 134 47 mode mode NOUN dpc-4458 134 48 0.126 0.126 NUM dpc-4458 134 49 weighted weight VERB dpc-4458 134 50 mode mode NOUN dpc-4458 134 51 0.149 0.149 NUM dpc-4458 134 52 bp bp PROPN dpc-4458 134 53 finn finn PROPN dpc-4458 134 54 - - PUNCT dpc-4458 134 55 b b NOUN dpc-4458 134 56 - - PUNCT dpc-4458 134 57 l12_psori_vulg l12_psori_vulg ADJ dpc-4458 134 58 inverse inverse NOUN dpc-4458 134 59 variance variance NOUN dpc-4458 134 60 weighted weight VERB dpc-4458 134 61 0.319 0.319 NUM dpc-4458 134 62 mr mr PROPN dpc-4458 134 63 - - PUNCT dpc-4458 134 64 egger egger NOUN dpc-4458 134 65 0.917 0.917 NUM dpc-4458 134 66 weighted weight VERB dpc-4458 134 67 median median NOUN dpc-4458 134 68 0.902 0.902 NUM dpc-4458 134 69 simple simple ADJ dpc-4458 134 70 mode mode NOUN dpc-4458 134 71 0.746 0.746 NUM dpc-4458 134 72 weighted weighted ADJ dpc-4458 134 73 mode mode NOUN dpc-4458 134 74 0.756 0.756 NUM dpc-4458 134 75 abbreviations abbreviation NOUN dpc-4458 134 76 : : PUNCT dpc-4458 135 1 bp bp PROPN dpc-4458 135 2 : : PUNCT dpc-4458 135 3 bullous bullous ADJ dpc-4458 135 4 pemphigoid pemphigoid ADV dpc-4458 135 5 ; ; PUNCT dpc-4458 135 6 mr mr PROPN dpc-4458 135 7 : : PUNCT dpc-4458 135 8 mendelian mendelian ADJ dpc-4458 135 9 randomization randomization NOUN dpc-4458 135 10 . . PUNCT dpc-4458 136 1 6 6 NUM dpc-4458 136 2 original original ADJ dpc-4458 136 3 article article NOUN dpc-4458 136 4 | | ADV dpc-4458 136 5 dermatol dermatol ADJ dpc-4458 136 6 pract pract NOUN dpc-4458 136 7 concept concept NOUN dpc-4458 136 8 . . PUNCT dpc-4458 137 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 137 2 inhibitors inhibitor NOUN dpc-4458 137 3 ( ( PUNCT dpc-4458 137 4 e.g. e.g. ADV dpc-4458 137 5 , , PUNCT dpc-4458 137 6 secukinumab secukinumab NOUN dpc-4458 137 7 or or CCONJ dpc-4458 137 8 ustekinumab ustekinumab NOUN dpc-4458 137 9 ) ) PUNCT dpc-4458 137 10 , , PUNCT dpc-4458 137 11 could could AUX dpc-4458 137 12 contribute contribute VERB dpc-4458 137 13 to to ADP dpc-4458 137 14 autoimmune autoimmune ADJ dpc-4458 137 15 processes process NOUN dpc-4458 137 16 and and CCONJ dpc-4458 137 17 may may AUX dpc-4458 137 18 also also ADV dpc-4458 137 19 be be AUX dpc-4458 137 20 a a DET dpc-4458 137 21 cause cause NOUN dpc-4458 137 22 of of ADP dpc-4458 137 23 bp bp PROPN dpc-4458 137 24 development development NOUN dpc-4458 138 1 [ [ X dpc-4458 138 2 12 12 NUM dpc-4458 138 3 , , PUNCT dpc-4458 138 4 35 35 NUM dpc-4458 138 5 ] ] PUNCT dpc-4458 138 6 . . PUNCT dpc-4458 139 1 as as SCONJ dpc-4458 139 2 mentioned mention VERB dpc-4458 139 3 , , PUNCT dpc-4458 139 4 specific specific ADJ dpc-4458 139 5 autoantibodies autoantibody NOUN dpc-4458 139 6 have have AUX dpc-4458 139 7 been be AUX dpc-4458 139 8 identified identify VERB dpc-4458 139 9 in in ADP dpc-4458 139 10 bp bp PROPN dpc-4458 139 11 ( ( PUNCT dpc-4458 139 12 bp180 bp180 PROPN dpc-4458 139 13 , , PUNCT dpc-4458 139 14 bp230 bp230 PROPN dpc-4458 139 15 ) ) PUNCT dpc-4458 139 16 . . PUNCT dpc-4458 140 1 although although SCONJ dpc-4458 140 2 these these DET dpc-4458 140 3 autoantibodies autoantibody NOUN dpc-4458 140 4 rarely rarely ADV dpc-4458 140 5 exist exist VERB dpc-4458 140 6 in in ADP dpc-4458 140 7 psoriasis psoriasis NOUN dpc-4458 140 8 , , PUNCT dpc-4458 140 9 there there PRON dpc-4458 140 10 may may AUX dpc-4458 140 11 be be AUX dpc-4458 140 12 other other ADJ dpc-4458 140 13 autoantibodies autoantibody NOUN dpc-4458 140 14 stimulated stimulate VERB dpc-4458 140 15 by by ADP dpc-4458 140 16 t t NOUN dpc-4458 140 17 cell cell NOUN dpc-4458 140 18 dysregulation dysregulation NOUN dpc-4458 140 19 in in ADP dpc-4458 140 20 psoriasis psoriasis NOUN dpc-4458 140 21 patients patient NOUN dpc-4458 140 22 . . PUNCT dpc-4458 141 1 a a DET dpc-4458 141 2 common common ADJ dpc-4458 141 3 characteristic characteristic NOUN dpc-4458 141 4 of of ADP dpc-4458 141 5 psoriasis psoriasis NOUN dpc-4458 141 6 and and CCONJ dpc-4458 141 7 bp bp PROPN dpc-4458 141 8 is be AUX dpc-4458 141 9 the the DET dpc-4458 141 10 disruption disruption NOUN dpc-4458 141 11 of of ADP dpc-4458 141 12 the the DET dpc-4458 141 13 basement basement NOUN dpc-4458 141 14 membrane membrane NOUN dpc-4458 141 15 integrity integrity NOUN dpc-4458 141 16 [ [ X dpc-4458 141 17 33 33 NUM dpc-4458 141 18 ] ] PUNCT dpc-4458 141 19 . . PUNCT dpc-4458 142 1 our our PRON dpc-4458 142 2 mr mr PROPN dpc-4458 142 3 analysis analysis NOUN dpc-4458 142 4 indicated indicate VERB dpc-4458 142 5 that that SCONJ dpc-4458 142 6 , , PUNCT dpc-4458 142 7 for for ADP dpc-4458 142 8 psoriasis psoriasis NOUN dpc-4458 142 9 patients patient NOUN dpc-4458 142 10 , , PUNCT dpc-4458 142 11 we we PRON dpc-4458 142 12 should should AUX dpc-4458 142 13 work work VERB dpc-4458 142 14 on on ADP dpc-4458 142 15 preventing prevent VERB dpc-4458 142 16 bp bp PROPN dpc-4458 142 17 development development PROPN dpc-4458 142 18 early early ADV dpc-4458 142 19 and and CCONJ dpc-4458 142 20 carefully carefully ADV dpc-4458 142 21 formulate formulate VERB dpc-4458 142 22 clinical clinical ADJ dpc-4458 142 23 strategies strategy NOUN dpc-4458 142 24 . . PUNCT dpc-4458 143 1 usually usually ADV dpc-4458 143 2 , , PUNCT dpc-4458 143 3 mr mr PROPN dpc-4458 143 4 analysis analysis NOUN dpc-4458 143 5 chooses choose VERB dpc-4458 143 6 an an DET dpc-4458 143 7 exposure exposure NOUN dpc-4458 143 8 and and CCONJ dpc-4458 143 9 an an DET dpc-4458 143 10 outcome outcome NOUN dpc-4458 143 11 . . PUNCT dpc-4458 144 1 in in ADP dpc-4458 144 2 our our PRON dpc-4458 144 3 research research NOUN dpc-4458 144 4 , , PUNCT dpc-4458 144 5 we we PRON dpc-4458 144 6 chose choose VERB dpc-4458 144 7 three three NUM dpc-4458 144 8 cohorts cohort NOUN dpc-4458 144 9 for for ADP dpc-4458 144 10 psoriasis psoriasis NOUN dpc-4458 144 11 increased increase VERB dpc-4458 144 12 risk risk NOUN dpc-4458 144 13 of of ADP dpc-4458 144 14 bp bp PROPN dpc-4458 145 1 [ [ X dpc-4458 145 2 12 12 NUM dpc-4458 145 3 ] ] PUNCT dpc-4458 145 4 . . PUNCT dpc-4458 146 1 in in ADP dpc-4458 146 2 addition addition NOUN dpc-4458 146 3 , , PUNCT dpc-4458 146 4 a a DET dpc-4458 146 5 systematic systematic ADJ dpc-4458 146 6 review review NOUN dpc-4458 146 7 and and CCONJ dpc-4458 146 8 meta meta ADJ dpc-4458 146 9 - - PUNCT dpc-4458 146 10 analysis analysis NOUN dpc-4458 146 11 showed show VERB dpc-4458 146 12 a a DET dpc-4458 146 13 significantly significantly ADV dpc-4458 146 14 higher high ADJ dpc-4458 146 15 rate rate NOUN dpc-4458 146 16 of of ADP dpc-4458 146 17 psoriasis psoriasis NOUN dpc-4458 146 18 in in ADP dpc-4458 146 19 patients patient NOUN dpc-4458 146 20 with with ADP dpc-4458 146 21 bp bp PROPN dpc-4458 146 22 compared compare VERB dpc-4458 146 23 to to ADP dpc-4458 146 24 controls control NOUN dpc-4458 146 25 [ [ X dpc-4458 146 26 33 33 NUM dpc-4458 146 27 ] ] PUNCT dpc-4458 146 28 . . PUNCT dpc-4458 147 1 the the DET dpc-4458 147 2 literature literature NOUN dpc-4458 147 3 has have AUX dpc-4458 147 4 also also ADV dpc-4458 147 5 reported report VERB dpc-4458 147 6 the the DET dpc-4458 147 7 co co NOUN dpc-4458 147 8 - - NOUN dpc-4458 147 9 occurrence occurrence NOUN dpc-4458 147 10 of of ADP dpc-4458 147 11 these these DET dpc-4458 147 12 two two NUM dpc-4458 147 13 diseases disease NOUN dpc-4458 147 14 [ [ X dpc-4458 147 15 34 34 NUM dpc-4458 147 16 ] ] PUNCT dpc-4458 147 17 . . PUNCT dpc-4458 148 1 to to ADP dpc-4458 148 2 date date NOUN dpc-4458 148 3 , , PUNCT dpc-4458 148 4 few few ADJ dpc-4458 148 5 studies study NOUN dpc-4458 148 6 have have AUX dpc-4458 148 7 reported report VERB dpc-4458 148 8 the the DET dpc-4458 148 9 potential potential ADJ dpc-4458 148 10 mechanisms mechanism NOUN dpc-4458 148 11 leading lead VERB dpc-4458 148 12 to to ADP dpc-4458 148 13 the the DET dpc-4458 148 14 association association NOUN dpc-4458 148 15 between between ADP dpc-4458 148 16 psoriasis psoriasis NOUN dpc-4458 148 17 and and CCONJ dpc-4458 148 18 bp bp PROPN dpc-4458 148 19 . . PUNCT dpc-4458 149 1 phototherapy phototherapy NOUN dpc-4458 149 2 is be AUX dpc-4458 149 3 a a DET dpc-4458 149 4 prevalent prevalent ADJ dpc-4458 149 5 treatment treatment NOUN dpc-4458 149 6 for for ADP dpc-4458 149 7 patients patient NOUN dpc-4458 149 8 with with ADP dpc-4458 149 9 psoriasis psoriasis NOUN dpc-4458 149 10 that that PRON dpc-4458 149 11 may may AUX dpc-4458 149 12 lead lead VERB dpc-4458 149 13 to to ADP dpc-4458 149 14 autoantibody autoantibody ADJ dpc-4458 149 15 formation formation NOUN dpc-4458 149 16 due due ADP dpc-4458 149 17 to to ADP dpc-4458 149 18 the the DET dpc-4458 149 19 change change NOUN dpc-4458 149 20 of of ADP dpc-4458 149 21 the the DET dpc-4458 149 22 antigenicity antigenicity NOUN dpc-4458 149 23 of of ADP dpc-4458 149 24 the the DET dpc-4458 149 25 basement basement NOUN dpc-4458 149 26 membrane membrane NOUN dpc-4458 149 27 [ [ X dpc-4458 149 28 12 12 NUM dpc-4458 149 29 ] ] PUNCT dpc-4458 149 30 . . PUNCT dpc-4458 150 1 utilization utilization NOUN dpc-4458 150 2 of of ADP dpc-4458 150 3 immunosuppressants immunosuppressant NOUN dpc-4458 150 4 , , PUNCT dpc-4458 150 5 such such ADJ dpc-4458 150 6 as as ADP dpc-4458 150 7 biologic biologic ADJ dpc-4458 150 8 agents agent NOUN dpc-4458 150 9 , , PUNCT dpc-4458 150 10 is be AUX dpc-4458 150 11 another another DET dpc-4458 150 12 explanation explanation NOUN dpc-4458 150 13 for for ADP dpc-4458 150 14 how how SCONJ dpc-4458 150 15 psoriasis psoriasis NOUN dpc-4458 150 16 could could AUX dpc-4458 150 17 increase increase VERB dpc-4458 150 18 the the DET dpc-4458 150 19 risk risk NOUN dpc-4458 150 20 of of ADP dpc-4458 150 21 bp bp PROPN dpc-4458 150 22 . . PUNCT dpc-4458 151 1 the the DET dpc-4458 151 2 use use NOUN dpc-4458 151 3 of of ADP dpc-4458 151 4 biologic biologic ADJ dpc-4458 151 5 agents agent NOUN dpc-4458 151 6 , , PUNCT dpc-4458 151 7 for for ADP dpc-4458 151 8 instance instance NOUN dpc-4458 151 9 , , PUNCT dpc-4458 151 10 tnf tnf PROPN dpc-4458 151 11 - - PUNCT dpc-4458 151 12 α α PROPN dpc-4458 151 13 table table NOUN dpc-4458 151 14 4 4 NUM dpc-4458 151 15 . . PUNCT dpc-4458 151 16 sensitivity sensitivity NOUN dpc-4458 151 17 analysis analysis NOUN dpc-4458 151 18 of of ADP dpc-4458 151 19 our our PRON dpc-4458 151 20 mr mr PROPN dpc-4458 151 21 analysis analysis NOUN dpc-4458 151 22 . . PUNCT dpc-4458 152 1 psoriasis psoriasis NOUN dpc-4458 153 1 i i NOUN dpc-4458 153 2 d d PROPN dpc-4458 153 3 q q PROPN dpc-4458 153 4 p p NOUN dpc-4458 153 5 - - PUNCT dpc-4458 153 6 value value NOUN dpc-4458 153 7 for for ADP dpc-4458 153 8 cochran cochran PROPN dpc-4458 153 9 q q PROPN dpc-4458 153 10 test test NOUN dpc-4458 153 11 egger egger NOUN dpc-4458 153 12 - - PUNCT dpc-4458 153 13 intercept intercept NOUN dpc-4458 153 14 p p NOUN dpc-4458 153 15 - - PUNCT dpc-4458 153 16 value value NOUN dpc-4458 153 17 for for ADP dpc-4458 153 18 mr mr PROPN dpc-4458 153 19 - - PUNCT dpc-4458 153 20 egger egger NOUN dpc-4458 153 21 intercept intercept NOUN dpc-4458 153 22 p p NOUN dpc-4458 153 23 - - PUNCT dpc-4458 153 24 value value NOUN dpc-4458 153 25 for for ADP dpc-4458 153 26 mr mr PROPN dpc-4458 153 27 - - PUNCT dpc-4458 153 28 presso presso NOUN dpc-4458 153 29 global global ADJ dpc-4458 153 30 test test NOUN dpc-4458 153 31 ebi ebi VERB dpc-4458 153 32 - - PUNCT dpc-4458 153 33 a a DET dpc-4458 153 34 - - PUNCT dpc-4458 153 35 gcst90018907 gcst90018907 PROPN dpc-4458 153 36 16.227 16.227 NUM dpc-4458 153 37 0.181 0.181 NUM dpc-4458 153 38 -0.020 -0.020 NOUN dpc-4458 153 39 0.738 0.738 NUM dpc-4458 153 40 0.226 0.226 NUM dpc-4458 153 41 ukb ukb ADJ dpc-4458 153 42 - - PUNCT dpc-4458 153 43 b-10537 b-10537 NOUN dpc-4458 153 44 18.495 18.495 NUM dpc-4458 153 45 0.489 0.489 NUM dpc-4458 153 46 0.051 0.051 NUM dpc-4458 153 47 0.148 0.148 NUM dpc-4458 153 48 0.417 0.417 NUM dpc-4458 153 49 finn finn PROPN dpc-4458 153 50 - - PUNCT dpc-4458 153 51 b b NOUN dpc-4458 153 52 - - PUNCT dpc-4458 153 53 l12_psori_vulg l12_psori_vulg PROPN dpc-4458 153 54 14.829 14.829 NUM dpc-4458 153 55 0.095 0.095 NUM dpc-4458 153 56 -0.112 -0.112 NUM dpc-4458 153 57 0.279 0.279 NUM dpc-4458 153 58 0.160 0.160 NUM dpc-4458 153 59 abbreviations abbreviation NOUN dpc-4458 153 60 : : PUNCT dpc-4458 153 61 mr mr PROPN dpc-4458 153 62 : : PUNCT dpc-4458 153 63 mendelian mendelian ADJ dpc-4458 153 64 randomization randomization NOUN dpc-4458 153 65 ; ; PUNCT dpc-4458 153 66 mr mr PROPN dpc-4458 153 67 - - PUNCT dpc-4458 153 68 presso presso NOUN dpc-4458 153 69 : : PUNCT dpc-4458 153 70 mendelian mendelian ADJ dpc-4458 153 71 randomization randomization NOUN dpc-4458 153 72 pleiotropy pleiotropy VERB dpc-4458 153 73 residual residual ADJ dpc-4458 153 74 sum sum NOUN dpc-4458 153 75 and and CCONJ dpc-4458 153 76 outlier outlier NOUN dpc-4458 153 77 . . PUNCT dpc-4458 154 1 a a DET dpc-4458 154 2 b b NOUN dpc-4458 154 3 c c PROPN dpc-4458 154 4 mr mr PROPN dpc-4458 154 5 test test PROPN dpc-4458 154 6 mr mr PROPN dpc-4458 154 7 test test VERB dpc-4458 154 8 1.0 1.0 NUM dpc-4458 154 9 0.75 0.75 NUM dpc-4458 154 10 0.25 0.25 NUM dpc-4458 154 11 0.00 0.00 NUM dpc-4458 154 12 -0.25 -0.25 NUM dpc-4458 154 13 -0.50 -0.50 NUM dpc-4458 154 14 0.005 0.005 NUM dpc-4458 154 15 0.010 0.010 NUM dpc-4458 154 16 0.015 0.015 NUM dpc-4458 154 17 0.020 0.020 NUM dpc-4458 154 18 0.50 0.50 NUM dpc-4458 154 19 0.25 0.25 NUM dpc-4458 154 20 0.00 0.00 NUM dpc-4458 154 21 -0.25 -0.25 NUM dpc-4458 154 22 0.3 0.3 NUM dpc-4458 154 23 0.6 0.6 NUM dpc-4458 154 24 0.9 0.9 NUM dpc-4458 154 25 0.5 0.5 NUM dpc-4458 154 26 0.0 0.0 NUM dpc-4458 154 27 0.5 0.5 NUM dpc-4458 154 28 sn sn PROPN dpc-4458 154 29 p p PROPN dpc-4458 154 30 ef ef X dpc-4458 154 31 fe fe X dpc-4458 154 32 ct ct NUM dpc-4458 154 33 o o PROPN dpc-4458 154 34 n n INTJ dpc-4458 154 35 bu bu INTJ dpc-4458 154 36 llo llo INTJ dpc-4458 154 37 us we PRON dpc-4458 155 1 p p X dpc-4458 155 2 em em PRON dpc-4458 155 3 ph ph VERB dpc-4458 155 4 ig ig PROPN dpc-4458 155 5 oi oi INTJ dpc-4458 156 1 d d X dpc-4458 156 2 || || PUNCT dpc-4458 157 1 i i PRON dpc-4458 157 2 d d NOUN dpc-4458 157 3 : : PUNCT dpc-4458 157 4 fi fi NOUN dpc-4458 157 5 nn nn PROPN dpc-4458 158 1 -b -b PUNCT dpc-4458 158 2 -l -l NUM dpc-4458 158 3 12 12 NUM dpc-4458 159 1 _ _ PUNCT dpc-4458 159 2 p p X dpc-4458 160 1 em em PRON dpc-4458 160 2 ph ph VERB dpc-4458 160 3 ig ig PROPN dpc-4458 160 4 o o NOUN dpc-4458 160 5 ld ld PROPN dpc-4458 161 1 _ _ PUNCT dpc-4458 161 2 b b PUNCT dpc-4458 162 1 u u X dpc-4458 162 2 ll ll AUX dpc-4458 162 3 sn sn PROPN dpc-4458 162 4 p p PROPN dpc-4458 162 5 ef ef X dpc-4458 162 6 fe fe X dpc-4458 162 7 ct ct NUM dpc-4458 162 8 o o PROPN dpc-4458 162 9 n n INTJ dpc-4458 162 10 bu bu INTJ dpc-4458 162 11 llo llo INTJ dpc-4458 162 12 us we PRON dpc-4458 163 1 p p X dpc-4458 163 2 em em PRON dpc-4458 163 3 ph ph VERB dpc-4458 163 4 ig ig PROPN dpc-4458 163 5 oi oi INTJ dpc-4458 164 1 d d X dpc-4458 164 2 || || PUNCT dpc-4458 165 1 i i PRON dpc-4458 165 2 d d NOUN dpc-4458 165 3 : : PUNCT dpc-4458 165 4 fi fi NOUN dpc-4458 165 5 nn nn PROPN dpc-4458 166 1 -b -b PUNCT dpc-4458 166 2 -l -l NUM dpc-4458 166 3 12 12 NUM dpc-4458 167 1 _ _ PUNCT dpc-4458 167 2 p p X dpc-4458 168 1 em em PRON dpc-4458 168 2 ph ph VERB dpc-4458 168 3 ig ig PROPN dpc-4458 168 4 o o NOUN dpc-4458 168 5 ld ld PROPN dpc-4458 169 1 _ _ PUNCT dpc-4458 169 2 b b PUNCT dpc-4458 170 1 u u X dpc-4458 170 2 ll ll AUX dpc-4458 170 3 sn sn PROPN dpc-4458 170 4 p p PROPN dpc-4458 170 5 ef ef X dpc-4458 170 6 fe fe X dpc-4458 170 7 ct ct NUM dpc-4458 170 8 o o PROPN dpc-4458 170 9 n n INTJ dpc-4458 170 10 bu bu INTJ dpc-4458 170 11 llo llo INTJ dpc-4458 170 12 us we PRON dpc-4458 171 1 p p X dpc-4458 171 2 em em PRON dpc-4458 171 3 ph ph VERB dpc-4458 171 4 ig ig PROPN dpc-4458 171 5 oi oi INTJ dpc-4458 172 1 d d X dpc-4458 172 2 || || PUNCT dpc-4458 173 1 i i PRON dpc-4458 173 2 d d NOUN dpc-4458 173 3 : : PUNCT dpc-4458 173 4 fi fi NOUN dpc-4458 173 5 nn nn PROPN dpc-4458 174 1 -b -b PUNCT dpc-4458 174 2 -l -l NUM dpc-4458 174 3 12 12 NUM dpc-4458 175 1 _ _ PUNCT dpc-4458 175 2 p p X dpc-4458 176 1 em em PRON dpc-4458 176 2 ph ph VERB dpc-4458 176 3 ig ig PROPN dpc-4458 176 4 o o NOUN dpc-4458 176 5 ld ld PROPN dpc-4458 177 1 _ _ PUNCT dpc-4458 177 2 b b PUNCT dpc-4458 178 1 u u X dpc-4458 178 2 ll ll AUX dpc-4458 178 3 1.0 1.0 NUM dpc-4458 178 4 inverse inverse NOUN dpc-4458 178 5 variance variance NOUN dpc-4458 178 6 weighted weight VERB dpc-4458 178 7 mr mr PROPN dpc-4458 178 8 egger egger PROPN dpc-4458 178 9 simple simple ADJ dpc-4458 178 10 mode mode NOUN dpc-4458 178 11 weighted weight VERB dpc-4458 178 12 median median PROPN dpc-4458 178 13 weighted weight VERB dpc-4458 178 14 mode mode PROPN dpc-4458 178 15 inverse inverse NOUN dpc-4458 178 16 variance variance NOUN dpc-4458 178 17 weighted weight VERB dpc-4458 178 18 mr mr PROPN dpc-4458 178 19 egger egger PROPN dpc-4458 178 20 simple simple ADJ dpc-4458 178 21 mode mode NOUN dpc-4458 178 22 weighted weight VERB dpc-4458 178 23 median median PROPN dpc-4458 178 24 weighted weight VERB dpc-4458 178 25 mode mode PROPN dpc-4458 178 26 inverse inverse NOUN dpc-4458 178 27 variance variance NOUN dpc-4458 178 28 weighted weight VERB dpc-4458 178 29 mr mr PROPN dpc-4458 178 30 egger egger PROPN dpc-4458 178 31 simple simple ADJ dpc-4458 178 32 mode mode NOUN dpc-4458 178 33 weighted weight VERB dpc-4458 178 34 median median PROPN dpc-4458 178 35 weighted weight VERB dpc-4458 178 36 mode mode PROPN dpc-4458 178 37 snp snp PROPN dpc-4458 178 38 e e PROPN dpc-4458 178 39 � � NOUN dpc-4458 178 40 ect ect VERB dpc-4458 178 41 on on ADP dpc-4458 178 42 psoriasis psoriasis NOUN dpc-4458 178 43 vulgaris vulgaris NOUN dpc-4458 178 44 || || PUNCT dpc-4458 179 1 id id X dpc-4458 179 2 : : PUNCT dpc-4458 179 3 ebi ebi X dpc-4458 179 4 - - PUNCT dpc-4458 179 5 a a DET dpc-4458 179 6 - - PUNCT dpc-4458 179 7 gcst90018907 gcst90018907 PROPN dpc-4458 179 8 snp snp NOUN dpc-4458 179 9 e e NOUN dpc-4458 179 10 � � NOUN dpc-4458 179 11 ect ect VERB dpc-4458 179 12 on on ADP dpc-4458 179 13 non non ADJ dpc-4458 179 14 - - ADJ dpc-4458 179 15 cancer cancer ADJ dpc-4458 179 16 illness illness NOUN dpc-4458 179 17 code code NOUN dpc-4458 179 18 , , PUNCT dpc-4458 179 19 self self NOUN dpc-4458 179 20 - - PUNCT dpc-4458 179 21 reported report VERB dpc-4458 179 22 : : PUNCT dpc-4458 179 23 psoriasis psoriasis NOUN dpc-4458 179 24 || || PUNCT dpc-4458 180 1 id id X dpc-4458 180 2 : : PUNCT dpc-4458 180 3 ukb ukb ADJ dpc-4458 180 4 - - PUNCT dpc-4458 180 5 b-10537 b-10537 NOUN dpc-4458 180 6 snp snp ADJ dpc-4458 180 7 e e NOUN dpc-4458 180 8 � � NOUN dpc-4458 180 9 ect ect VERB dpc-4458 180 10 on on ADP dpc-4458 180 11 psoriasis psoriasis NOUN dpc-4458 180 12 vulgaris vulgaris NOUN dpc-4458 180 13 || || PUNCT dpc-4458 181 1 id id X dpc-4458 181 2 : : PUNCT dpc-4458 181 3 finn finn PROPN dpc-4458 181 4 - - PUNCT dpc-4458 181 5 b b NOUN dpc-4458 181 6 - - PUNCT dpc-4458 181 7 l12_psori_vulg l12_psori_vulg NOUN dpc-4458 181 8 mr mr PROPN dpc-4458 181 9 test test NOUN dpc-4458 181 10 figure figure NOUN dpc-4458 181 11 4 4 NUM dpc-4458 181 12 . . PUNCT dpc-4458 182 1 scatter scatter NOUN dpc-4458 182 2 plots plot NOUN dpc-4458 182 3 showing show VERB dpc-4458 182 4 significant significant ADJ dpc-4458 182 5 causal causal ADJ dpc-4458 182 6 effects effect NOUN dpc-4458 182 7 among among ADP dpc-4458 182 8 three three NUM dpc-4458 182 9 psoriasis psoriasis NOUN dpc-4458 182 10 cohorts cohort NOUN dpc-4458 182 11 and and CCONJ dpc-4458 182 12 bp bp PROPN dpc-4458 182 13 , , PUNCT dpc-4458 182 14 respectively respectively ADV dpc-4458 182 15 : : PUNCT dpc-4458 182 16 ( ( PUNCT dpc-4458 182 17 a a X dpc-4458 182 18 ) ) PUNCT dpc-4458 182 19 ebi ebi X dpc-4458 182 20 - - PUNCT dpc-4458 182 21 a a DET dpc-4458 182 22 - - PUNCT dpc-4458 182 23 gcst90018907 gcst90018907 PROPN dpc-4458 182 24 , , PUNCT dpc-4458 182 25 ( ( PUNCT dpc-4458 182 26 b b X dpc-4458 182 27 ) ) PUNCT dpc-4458 182 28 ukb ukb PROPN dpc-4458 182 29 - - PUNCT dpc-4458 182 30 b-10537 b-10537 NOUN dpc-4458 182 31 , , PUNCT dpc-4458 182 32 ( ( PUNCT dpc-4458 182 33 c c X dpc-4458 182 34 ) ) PUNCT dpc-4458 182 35 finn finn PROPN dpc-4458 182 36 - - PUNCT dpc-4458 182 37 b b NOUN dpc-4458 182 38 - - PUNCT dpc-4458 182 39 l12_psori_vulg l12_psori_vulg ADJ dpc-4458 182 40 . . PUNCT dpc-4458 182 41 original original ADJ dpc-4458 182 42 article article NOUN dpc-4458 182 43 | | ADV dpc-4458 182 44 dermatol dermatol ADJ dpc-4458 182 45 pract pract NOUN dpc-4458 182 46 concept concept NOUN dpc-4458 182 47 . . PUNCT dpc-4458 183 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 183 2 7 7 NUM dpc-4458 183 3 transduct transduct NOUN dpc-4458 183 4 target target NOUN dpc-4458 183 5 ther ther ADV dpc-4458 183 6 . . PUNCT dpc-4458 184 1 2023;8(1):1 2023;8(1):1 NOUN dpc-4458 184 2 - - SYM dpc-4458 184 3 38 38 NUM dpc-4458 184 4 . . PUNCT dpc-4458 185 1 doi doi NOUN dpc-4458 185 2 : : PUNCT dpc-4458 185 3 10.1038 10.1038 NUM dpc-4458 185 4 / / SYM dpc-4458 185 5 s41392 s41392 VERB dpc-4458 185 6 - - PUNCT dpc-4458 185 7 023 023 NUM dpc-4458 185 8 -01655 -01655 NOUN dpc-4458 185 9 - - PUNCT dpc-4458 185 10 6 6 NUM dpc-4458 185 11 . . PUNCT dpc-4458 186 1 pmid pmid NOUN dpc-4458 186 2 : : PUNCT dpc-4458 186 3 38008779 38008779 NUM dpc-4458 186 4 . . PUNCT dpc-4458 187 1 2 2 X dpc-4458 187 2 . . X dpc-4458 187 3 iversen iversen PROPN dpc-4458 187 4 l l PROPN dpc-4458 187 5 , , PUNCT dpc-4458 187 6 daudén daudén PROPN dpc-4458 187 7 e e NOUN dpc-4458 187 8 , , PUNCT dpc-4458 187 9 segaert segaert PROPN dpc-4458 187 10 s s PROPN dpc-4458 187 11 , , PUNCT dpc-4458 187 12 et et PROPN dpc-4458 187 13 al al PROPN dpc-4458 187 14 . . PUNCT dpc-4458 188 1 reformulations reformulation NOUN dpc-4458 188 2 of of ADP dpc-4458 188 3 wellknown wellknown ADJ dpc-4458 188 4 active active ADJ dpc-4458 188 5 ingredients ingredient NOUN dpc-4458 188 6 in in ADP dpc-4458 188 7 the the DET dpc-4458 188 8 topical topical ADJ dpc-4458 188 9 treatment treatment NOUN dpc-4458 188 10 of of ADP dpc-4458 188 11 psoriasis psoriasis NOUN dpc-4458 188 12 vulgaris vulgaris NOUN dpc-4458 188 13 can can AUX dpc-4458 188 14 improve improve VERB dpc-4458 188 15 clinical clinical ADJ dpc-4458 188 16 outcomes outcome NOUN dpc-4458 188 17 for for ADP dpc-4458 188 18 patients patient NOUN dpc-4458 188 19 . . PUNCT dpc-4458 189 1 j j PROPN dpc-4458 189 2 eur eur PROPN dpc-4458 189 3 acad acad PROPN dpc-4458 189 4 dermatol dermatol NOUN dpc-4458 189 5 venereol venereol NOUN dpc-4458 189 6 . . PUNCT dpc-4458 190 1 2017;31(8):1271 2017;31(8):1271 NUM dpc-4458 190 2 - - SYM dpc-4458 190 3 1284 1284 NUM dpc-4458 190 4 . . PUNCT dpc-4458 191 1 doi doi NOUN dpc-4458 191 2 : : PUNCT dpc-4458 191 3 10.1111 10.1111 NUM dpc-4458 191 4 / / SYM dpc-4458 191 5 jdv jdv NOUN dpc-4458 191 6 .14277 .14277 PROPN dpc-4458 191 7 . . PUNCT dpc-4458 192 1 pmid pmid NOUN dpc-4458 192 2 : : PUNCT dpc-4458 192 3 28419600 28419600 NUM dpc-4458 192 4 . . PUNCT dpc-4458 193 1 3 3 X dpc-4458 193 2 . . X dpc-4458 193 3 krajina krajina PROPN dpc-4458 193 4 i i PROPN dpc-4458 193 5 , , PUNCT dpc-4458 193 6 stupin stupin NOUN dpc-4458 193 7 a a PROPN dpc-4458 193 8 , , PUNCT dpc-4458 193 9 šola šola PROPN dpc-4458 193 10 m m NOUN dpc-4458 193 11 , , PUNCT dpc-4458 193 12 mihalj mihalj ADJ dpc-4458 193 13 m. m. NOUN dpc-4458 193 14 oxidative oxidative ADJ dpc-4458 193 15 stress stress NOUN dpc-4458 193 16 induced induce VERB dpc-4458 193 17 by by ADP dpc-4458 193 18 high high ADJ dpc-4458 193 19 salt salt NOUN dpc-4458 193 20 diet diet NOUN dpc-4458 193 21 — — PUNCT dpc-4458 193 22 possible possible ADJ dpc-4458 193 23 implications implication NOUN dpc-4458 193 24 for for ADP dpc-4458 193 25 development development NOUN dpc-4458 193 26 and and CCONJ dpc-4458 193 27 clinical clinical ADJ dpc-4458 193 28 manifestation manifestation NOUN dpc-4458 193 29 of of ADP dpc-4458 193 30 cutaneous cutaneous ADJ dpc-4458 193 31 inflammation inflammation NOUN dpc-4458 193 32 and and CCONJ dpc-4458 193 33 endothelial endothelial ADJ dpc-4458 193 34 dysfunction dysfunction NOUN dpc-4458 193 35 in in ADP dpc-4458 193 36 psoriasis psoriasis NOUN dpc-4458 193 37 vulgaris vulgaris NOUN dpc-4458 193 38 . . PUNCT dpc-4458 193 39 antioxidants antioxidant NOUN dpc-4458 193 40 ( ( PUNCT dpc-4458 193 41 basel basel PROPN dpc-4458 193 42 ) ) PUNCT dpc-4458 193 43 . . PUNCT dpc-4458 194 1 2022;11(7):1269 2022;11(7):1269 NUM dpc-4458 194 2 . . PUNCT dpc-4458 194 3 doi doi NOUN dpc-4458 194 4 : : PUNCT dpc-4458 194 5 10.3390 10.3390 NUM dpc-4458 194 6 / / SYM dpc-4458 194 7 antiox11071269 antiox11071269 PROPN dpc-4458 194 8 . . PUNCT dpc-4458 195 1 pmid pmid NOUN dpc-4458 195 2 : : PUNCT dpc-4458 195 3 35883760 35883760 NUM dpc-4458 195 4 . . PUNCT dpc-4458 196 1 4 4 X dpc-4458 196 2 . . X dpc-4458 196 3 meyer meyer PROPN dpc-4458 196 4 n n CCONJ dpc-4458 196 5 , , PUNCT dpc-4458 196 6 paul paul PROPN dpc-4458 196 7 c c PROPN dpc-4458 196 8 , , PUNCT dpc-4458 196 9 feneron feneron PROPN dpc-4458 196 10 d d NOUN dpc-4458 196 11 , , PUNCT dpc-4458 196 12 et et PROPN dpc-4458 196 13 al al PROPN dpc-4458 196 14 . . PUNCT dpc-4458 196 15 psoriasis psoriasis NOUN dpc-4458 196 16 : : PUNCT dpc-4458 196 17 an an DET dpc-4458 196 18 epidemiological epidemiological ADJ dpc-4458 196 19 evaluation evaluation NOUN dpc-4458 196 20 of of ADP dpc-4458 196 21 disease disease NOUN dpc-4458 196 22 burden burden NOUN dpc-4458 196 23 in in ADP dpc-4458 196 24 590 590 NUM dpc-4458 196 25 patients patient NOUN dpc-4458 196 26 . . PUNCT dpc-4458 197 1 j j PROPN dpc-4458 197 2 eur eur PROPN dpc-4458 197 3 acad acad PROPN dpc-4458 197 4 dermatol dermatol NOUN dpc-4458 197 5 venereol venereol NOUN dpc-4458 197 6 . . PUNCT dpc-4458 198 1 2010;24(9):1075 2010;24(9):1075 NUM dpc-4458 198 2 - - PUNCT dpc-4458 198 3 1082 1082 NUM dpc-4458 198 4 . . PUNCT dpc-4458 199 1 doi doi NOUN dpc-4458 199 2 : : PUNCT dpc-4458 199 3 10.1111 10.1111 NUM dpc-4458 199 4 / / SYM dpc-4458 199 5 j.1468 j.1468 NOUN dpc-4458 199 6 - - PUNCT dpc-4458 199 7 3083 3083 NUM dpc-4458 199 8 .2010.03600.x .2010.03600.x NOUN dpc-4458 199 9 . . PUNCT dpc-4458 200 1 pmid pmid NOUN dpc-4458 200 2 : : PUNCT dpc-4458 200 3 20236205 20236205 NUM dpc-4458 200 4 . . PUNCT dpc-4458 201 1 5 5 X dpc-4458 201 2 . . X dpc-4458 201 3 sahi sahi PROPN dpc-4458 201 4 fm fm PROPN dpc-4458 201 5 , , PUNCT dpc-4458 201 6 masood masood PROPN dpc-4458 201 7 a a PROPN dpc-4458 201 8 , , PUNCT dpc-4458 201 9 danawar danawar NOUN dpc-4458 201 10 na na NOUN dpc-4458 201 11 , , PUNCT dpc-4458 201 12 mekaiel mekaiel PROPN dpc-4458 201 13 a a PRON dpc-4458 201 14 , , PUNCT dpc-4458 201 15 malik malik PROPN dpc-4458 201 16 bh bh PROPN dpc-4458 201 17 . . PROPN dpc-4458 201 18 association association PROPN dpc-4458 201 19 between between ADP dpc-4458 201 20 psoriasis psoriasis NOUN dpc-4458 201 21 and and CCONJ dpc-4458 201 22 depression depression NOUN dpc-4458 201 23 : : PUNCT dpc-4458 201 24 a a DET dpc-4458 201 25 traditional traditional ADJ dpc-4458 201 26 review review NOUN dpc-4458 201 27 . . PUNCT dpc-4458 202 1 cureus cureus NOUN dpc-4458 202 2 . . PUNCT dpc-4458 203 1 2020;12(8):e9708 2020;12(8):e9708 X dpc-4458 203 2 . . PUNCT dpc-4458 203 3 doi doi NOUN dpc-4458 203 4 : : PUNCT dpc-4458 203 5 10.7759 10.7759 NUM dpc-4458 203 6 / / SYM dpc-4458 203 7 cureus.9708 cureus.9708 PROPN dpc-4458 203 8 . . PUNCT dpc-4458 204 1 pmid pmid NOUN dpc-4458 204 2 : : PUNCT dpc-4458 204 3 32944430 32944430 NUM dpc-4458 204 4 . . PUNCT dpc-4458 205 1 6 6 NUM dpc-4458 205 2 . . X dpc-4458 205 3 hoffman hoffman PROPN dpc-4458 205 4 mb mb PROPN dpc-4458 205 5 , , PUNCT dpc-4458 205 6 hill hill PROPN dpc-4458 205 7 d d PROPN dpc-4458 205 8 , , PUNCT dpc-4458 205 9 feldman feldman PROPN dpc-4458 205 10 sr sr PROPN dpc-4458 205 11 . . PUNCT dpc-4458 206 1 current current ADJ dpc-4458 206 2 challenges challenge NOUN dpc-4458 206 3 and and CCONJ dpc-4458 206 4 emerging emerge VERB dpc-4458 206 5 drug drug NOUN dpc-4458 206 6 delivery delivery NOUN dpc-4458 206 7 strategies strategy NOUN dpc-4458 206 8 for for ADP dpc-4458 206 9 the the DET dpc-4458 206 10 treatment treatment NOUN dpc-4458 206 11 of of ADP dpc-4458 206 12 psoriasis psoriasis NOUN dpc-4458 206 13 . . PUNCT dpc-4458 207 1 expert expert NOUN dpc-4458 207 2 opin opin NOUN dpc-4458 207 3 drug drug NOUN dpc-4458 207 4 deliv deliv NOUN dpc-4458 207 5 . . PUNCT dpc-4458 208 1 2016;13(10):1461 2016;13(10):1461 NUM dpc-4458 208 2 - - SYM dpc-4458 208 3 1473 1473 NUM dpc-4458 208 4 . . PUNCT dpc-4458 209 1 doi doi NOUN dpc-4458 209 2 : : PUNCT dpc-4458 209 3 10.1080 10.1080 NUM dpc-4458 209 4 /17425247.2016.1188801 /17425247.2016.1188801 NOUN dpc-4458 209 5 . . PUNCT dpc-4458 210 1 pmid pmid NOUN dpc-4458 210 2 : : PUNCT dpc-4458 210 3 27164301 27164301 NUM dpc-4458 210 4 . . PUNCT dpc-4458 211 1 7 7 X dpc-4458 211 2 . . X dpc-4458 211 3 hammers hammer NOUN dpc-4458 211 4 cm cm PROPN dpc-4458 211 5 , , PUNCT dpc-4458 211 6 stanley stanley PROPN dpc-4458 211 7 jr jr PROPN dpc-4458 211 8 . . PROPN dpc-4458 211 9 mechanisms mechanism NOUN dpc-4458 211 10 of of ADP dpc-4458 211 11 disease disease NOUN dpc-4458 211 12 : : PUNCT dpc-4458 211 13 pemphigus pemphigus NOUN dpc-4458 211 14 and and CCONJ dpc-4458 211 15 bullous bullous ADJ dpc-4458 211 16 pemphigoid pemphigoid NOUN dpc-4458 211 17 . . PUNCT dpc-4458 212 1 annu annu PROPN dpc-4458 212 2 rev rev PROPN dpc-4458 212 3 pathol pathol NOUN dpc-4458 212 4 . . PUNCT dpc-4458 213 1 2016;11(1):175 2016;11(1):175 NUM dpc-4458 213 2 - - PUNCT dpc-4458 213 3 197 197 NUM dpc-4458 213 4 . . PUNCT dpc-4458 214 1 doi doi NOUN dpc-4458 214 2 : : PUNCT dpc-4458 214 3 10.1146 10.1146 NUM dpc-4458 214 4 / / SYM dpc-4458 214 5 annurev annurev ADJ dpc-4458 214 6 - - PUNCT dpc-4458 214 7 pathol-012615 pathol-012615 ADJ dpc-4458 214 8 - - PUNCT dpc-4458 214 9 044313 044313 NUM dpc-4458 214 10 . . PUNCT dpc-4458 215 1 pmid pmid NOUN dpc-4458 215 2 : : PUNCT dpc-4458 215 3 26907530 26907530 NUM dpc-4458 215 4 . . PUNCT dpc-4458 216 1 8 8 X dpc-4458 216 2 . . X dpc-4458 217 1 langan langan PROPN dpc-4458 217 2 sm sm PROPN dpc-4458 217 3 , , PUNCT dpc-4458 217 4 smeeth smeeth PROPN dpc-4458 217 5 l l PROPN dpc-4458 217 6 , , PUNCT dpc-4458 217 7 hubbard hubbard PROPN dpc-4458 217 8 r r PROPN dpc-4458 217 9 , , PUNCT dpc-4458 217 10 fleming fleming NOUN dpc-4458 217 11 km km PROPN dpc-4458 217 12 , , PUNCT dpc-4458 217 13 smith smith PROPN dpc-4458 217 14 cjp cjp PROPN dpc-4458 217 15 , , PUNCT dpc-4458 217 16 west west PROPN dpc-4458 217 17 j. j. PROPN dpc-4458 217 18 bullous bullous PROPN dpc-4458 217 19 pemphigoid pemphigoid NOUN dpc-4458 217 20 and and CCONJ dpc-4458 217 21 pemphigus pemphigus NOUN dpc-4458 217 22 vulgaris vulgaris NOUN dpc-4458 217 23 — — PUNCT dpc-4458 217 24 incidence incidence NOUN dpc-4458 217 25 and and CCONJ dpc-4458 217 26 mortality mortality NOUN dpc-4458 217 27 in in ADP dpc-4458 217 28 the the DET dpc-4458 217 29 uk uk PROPN dpc-4458 217 30 : : PUNCT dpc-4458 217 31 population population NOUN dpc-4458 217 32 - - PUNCT dpc-4458 217 33 based base VERB dpc-4458 217 34 cohort cohort NOUN dpc-4458 217 35 study study NOUN dpc-4458 217 36 . . PUNCT dpc-4458 218 1 bmj bmj PROPN dpc-4458 218 2 . . PUNCT dpc-4458 219 1 2008;337 2008;337 NUM dpc-4458 219 2 : : PUNCT dpc-4458 220 1 a180 a180 PROPN dpc-4458 220 2 . . PUNCT dpc-4458 220 3 doi doi PROPN dpc-4458 220 4 : : PUNCT dpc-4458 220 5 10.1136 10.1136 NUM dpc-4458 220 6 / / SYM dpc-4458 220 7 bmj.a180 bmj.a180 NUM dpc-4458 220 8 . . PUNCT dpc-4458 221 1 pmid pmid NOUN dpc-4458 221 2 : : PUNCT dpc-4458 221 3 18614511 18614511 NUM dpc-4458 221 4 . . PUNCT dpc-4458 222 1 9 9 X dpc-4458 222 2 . . X dpc-4458 222 3 schmidt schmidt PROPN dpc-4458 222 4 e e PROPN dpc-4458 222 5 , , PUNCT dpc-4458 222 6 zillikens zillikens PROPN dpc-4458 222 7 d. d. PROPN dpc-4458 222 8 pemphigoid pemphigoid PROPN dpc-4458 222 9 diseases disease NOUN dpc-4458 222 10 . . PUNCT dpc-4458 223 1 lancet lancet PROPN dpc-4458 223 2 . . PUNCT dpc-4458 224 1 2013 2013 NUM dpc-4458 224 2 ; ; PUNCT dpc-4458 224 3 381(9863):320 381(9863):320 NUM dpc-4458 224 4 - - SYM dpc-4458 224 5 332 332 NUM dpc-4458 224 6 . . PUNCT dpc-4458 225 1 doi doi NOUN dpc-4458 225 2 : : PUNCT dpc-4458 225 3 10.1016 10.1016 NUM dpc-4458 225 4 / / SYM dpc-4458 225 5 s0140 s0140 PROPN dpc-4458 225 6 - - PUNCT dpc-4458 225 7 6736(12)61140 6736(12)61140 NOUN dpc-4458 225 8 - - PUNCT dpc-4458 225 9 4 4 NUM dpc-4458 225 10 . . PUNCT dpc-4458 226 1 pmid pmid NOUN dpc-4458 226 2 : : PUNCT dpc-4458 226 3 23237497 23237497 NUM dpc-4458 226 4 . . PUNCT dpc-4458 227 1 10 10 NUM dpc-4458 227 2 . . PUNCT dpc-4458 228 1 kirtschig kirtschig PROPN dpc-4458 228 2 g g PROPN dpc-4458 228 3 , , PUNCT dpc-4458 228 4 middleton middleton PROPN dpc-4458 228 5 p p PROPN dpc-4458 228 6 , , PUNCT dpc-4458 228 7 bennett bennett PROPN dpc-4458 228 8 c c PROPN dpc-4458 228 9 , , PUNCT dpc-4458 228 10 murrell murrell PROPN dpc-4458 228 11 df df PROPN dpc-4458 228 12 , , PUNCT dpc-4458 228 13 wojnarowska wojnarowska PROPN dpc-4458 228 14 f f NUM dpc-4458 228 15 , , PUNCT dpc-4458 228 16 khumalo khumalo PROPN dpc-4458 228 17 np np PROPN dpc-4458 228 18 . . PUNCT dpc-4458 228 19 interventions intervention NOUN dpc-4458 228 20 for for ADP dpc-4458 228 21 bullous bullous ADJ dpc-4458 228 22 pemphigoid pemphigoid NOUN dpc-4458 228 23 . . PUNCT dpc-4458 229 1 cochrane cochrane NOUN dpc-4458 229 2 database database PROPN dpc-4458 229 3 syst syst PROPN dpc-4458 229 4 rev rev PROPN dpc-4458 229 5 . . PROPN dpc-4458 230 1 2010;(10):cd002292 2010;(10):cd002292 NUM dpc-4458 230 2 . . PUNCT dpc-4458 230 3 doi doi NOUN dpc-4458 230 4 : : PUNCT dpc-4458 230 5 10.1002 10.1002 NUM dpc-4458 230 6 /14651858.cd002292.pub3 /14651858.cd002292.pub3 NUM dpc-4458 230 7 . . PUNCT dpc-4458 231 1 pmid pmid NOUN dpc-4458 231 2 : : PUNCT dpc-4458 231 3 20927731 20927731 NUM dpc-4458 231 4 . . PUNCT dpc-4458 232 1 11 11 NUM dpc-4458 232 2 . . PUNCT dpc-4458 232 3 bastuji bastuji PROPN dpc-4458 232 4 - - PUNCT dpc-4458 232 5 garin garin PROPN dpc-4458 232 6 s s PROPN dpc-4458 232 7 , , PUNCT dpc-4458 232 8 joly joly PROPN dpc-4458 232 9 p p PROPN dpc-4458 232 10 , , PUNCT dpc-4458 232 11 lemordant lemordant PROPN dpc-4458 232 12 p p X dpc-4458 232 13 , , PUNCT dpc-4458 232 14 et et PROPN dpc-4458 232 15 al al PROPN dpc-4458 232 16 . . PUNCT dpc-4458 233 1 risk risk NOUN dpc-4458 233 2 factors factor NOUN dpc-4458 233 3 for for ADP dpc-4458 233 4 bullous bullous ADJ dpc-4458 233 5 pemphigoid pemphigoid NOUN dpc-4458 233 6 in in ADP dpc-4458 233 7 the the DET dpc-4458 233 8 elderly elderly ADJ dpc-4458 233 9 : : PUNCT dpc-4458 233 10 a a DET dpc-4458 233 11 prospective prospective ADJ dpc-4458 233 12 case case NOUN dpc-4458 233 13 – – PUNCT dpc-4458 233 14 control control NOUN dpc-4458 233 15 study study NOUN dpc-4458 233 16 . . PUNCT dpc-4458 234 1 j j PROPN dpc-4458 234 2 invest invest VERB dpc-4458 234 3 dermatol dermatol NOUN dpc-4458 234 4 . . PUNCT dpc-4458 235 1 2011;131(3):637 2011;131(3):637 NUM dpc-4458 235 2 - - SYM dpc-4458 235 3 643 643 NUM dpc-4458 235 4 . . PUNCT dpc-4458 235 5 doi doi NOUN dpc-4458 235 6 : : PUNCT dpc-4458 235 7 10.1038 10.1038 NUM dpc-4458 235 8 /jid.2010.301 /jid.2010.301 X dpc-4458 235 9 . . PUNCT dpc-4458 236 1 pmid pmid NOUN dpc-4458 236 2 : : PUNCT dpc-4458 236 3 20944650 20944650 NUM dpc-4458 236 4 . . PUNCT dpc-4458 237 1 12 12 NUM dpc-4458 237 2 . . PUNCT dpc-4458 238 1 ho ho PROPN dpc-4458 238 2 yh yh PROPN dpc-4458 238 3 , , PUNCT dpc-4458 238 4 hu hu PROPN dpc-4458 238 5 hy hy PROPN dpc-4458 238 6 , , PUNCT dpc-4458 238 7 chang chang PROPN dpc-4458 238 8 yt yt PROPN dpc-4458 238 9 , , PUNCT dpc-4458 238 10 li li PROPN dpc-4458 238 11 cp cp PROPN dpc-4458 238 12 , , PUNCT dpc-4458 238 13 wu wu PROPN dpc-4458 238 14 cy cy PROPN dpc-4458 238 15 . . PROPN dpc-4458 238 16 psoriasis psoriasis NOUN dpc-4458 238 17 is be AUX dpc-4458 238 18 associated associate VERB dpc-4458 238 19 with with ADP dpc-4458 238 20 increased increase VERB dpc-4458 238 21 risk risk NOUN dpc-4458 238 22 of of ADP dpc-4458 238 23 bullous bullous ADJ dpc-4458 238 24 pemphigoid pemphigoid NOUN dpc-4458 238 25 : : PUNCT dpc-4458 238 26 a a DET dpc-4458 238 27 nationwide nationwide ADJ dpc-4458 238 28 population population NOUN dpc-4458 238 29 - - PUNCT dpc-4458 238 30 based base VERB dpc-4458 238 31 cohort cohort NOUN dpc-4458 238 32 study study NOUN dpc-4458 238 33 in in ADP dpc-4458 238 34 taiwan taiwan PROPN dpc-4458 238 35 . . PUNCT dpc-4458 239 1 j j PROPN dpc-4458 239 2 dermatol dermatol NOUN dpc-4458 239 3 . . PUNCT dpc-4458 240 1 2019;46(7 2019;46(7 NUM dpc-4458 240 2 ): ): PUNCT dpc-4458 240 3 604 604 NUM dpc-4458 240 4 - - SYM dpc-4458 240 5 609 609 NUM dpc-4458 240 6 . . PUNCT dpc-4458 241 1 doi doi NOUN dpc-4458 241 2 : : PUNCT dpc-4458 241 3 10.1111/1346 10.1111/1346 NUM dpc-4458 241 4 - - SYM dpc-4458 241 5 8138.14902 8138.14902 NOUN dpc-4458 241 6 . . PUNCT dpc-4458 242 1 pmid pmid NOUN dpc-4458 242 2 : : PUNCT dpc-4458 242 3 31062428 31062428 NUM dpc-4458 242 4 . . PUNCT dpc-4458 243 1 13 13 NUM dpc-4458 243 2 . . PUNCT dpc-4458 243 3 mounier mounier PROPN dpc-4458 243 4 n n CCONJ dpc-4458 243 5 , , PUNCT dpc-4458 243 6 kutalik kutalik PROPN dpc-4458 243 7 z. z. PROPN dpc-4458 243 8 bias bias PROPN dpc-4458 243 9 correction correction NOUN dpc-4458 243 10 for for ADP dpc-4458 243 11 inverse inverse ADJ dpc-4458 243 12 variance variance NOUN dpc-4458 243 13 weighting weight VERB dpc-4458 243 14 mendelian mendelian ADJ dpc-4458 243 15 randomization randomization NOUN dpc-4458 243 16 . . PUNCT dpc-4458 244 1 genet genet PROPN dpc-4458 244 2 epidemiol epidemiol PROPN dpc-4458 244 3 . . PUNCT dpc-4458 245 1 2023;47(4 2023;47(4 NUM dpc-4458 245 2 ): ): PUNCT dpc-4458 245 3 314 314 NUM dpc-4458 245 4 - - SYM dpc-4458 245 5 331 331 NUM dpc-4458 245 6 . . PUNCT dpc-4458 246 1 doi doi NOUN dpc-4458 246 2 : : PUNCT dpc-4458 246 3 10.1002 10.1002 NUM dpc-4458 246 4 / / SYM dpc-4458 246 5 gepi.22522 gepi.22522 PROPN dpc-4458 246 6 . . PUNCT dpc-4458 247 1 pmid pmid NOUN dpc-4458 247 2 : : PUNCT dpc-4458 247 3 37036286 37036286 NUM dpc-4458 247 4 . . PUNCT dpc-4458 248 1 14 14 NUM dpc-4458 248 2 . . PUNCT dpc-4458 249 1 wang wang PROPN dpc-4458 249 2 k. k. PROPN dpc-4458 249 3 interval interval PROPN dpc-4458 249 4 estimate estimate NOUN dpc-4458 249 5 of of ADP dpc-4458 249 6 causal causal ADJ dpc-4458 249 7 effect effect NOUN dpc-4458 249 8 in in ADP dpc-4458 249 9 summary summary NOUN dpc-4458 249 10 data data NOUN dpc-4458 249 11 - - PUNCT dpc-4458 249 12 based base VERB dpc-4458 249 13 mendelian mendelian ADJ dpc-4458 249 14 randomization randomization NOUN dpc-4458 249 15 in in ADP dpc-4458 249 16 the the DET dpc-4458 249 17 presence presence NOUN dpc-4458 249 18 of of ADP dpc-4458 249 19 winner winner NOUN dpc-4458 249 20 ’s ’s PART dpc-4458 249 21 curse curse NOUN dpc-4458 249 22 . . PUNCT dpc-4458 250 1 genet genet PROPN dpc-4458 250 2 epidemiol epidemiol PROPN dpc-4458 250 3 . . PUNCT dpc-4458 251 1 2024;48(2):74 2024;48(2):74 NUM dpc-4458 251 2 - - SYM dpc-4458 251 3 84 84 NUM dpc-4458 251 4 . . PUNCT dpc-4458 252 1 doi doi NOUN dpc-4458 252 2 : : PUNCT dpc-4458 252 3 10.1002 10.1002 NUM dpc-4458 252 4 / / SYM dpc-4458 252 5 gepi.22545 gepi.22545 PROPN dpc-4458 252 6 . . PUNCT dpc-4458 253 1 pmid pmid NOUN dpc-4458 253 2 : : PUNCT dpc-4458 253 3 38282283 38282283 NUM dpc-4458 253 4 . . PUNCT dpc-4458 254 1 15 15 NUM dpc-4458 254 2 . . PUNCT dpc-4458 255 1 bowden bowden PROPN dpc-4458 255 2 j j PROPN dpc-4458 255 3 , , PUNCT dpc-4458 255 4 del del PROPN dpc-4458 255 5 greco greco PROPN dpc-4458 255 6 m m PROPN dpc-4458 255 7 f f PROPN dpc-4458 255 8 , , PUNCT dpc-4458 255 9 minelli minelli PROPN dpc-4458 255 10 c c PROPN dpc-4458 255 11 , , PUNCT dpc-4458 255 12 davey davey PROPN dpc-4458 255 13 smith smith PROPN dpc-4458 255 14 g g PROPN dpc-4458 255 15 , , PUNCT dpc-4458 255 16 sheehan sheehan PROPN dpc-4458 255 17 n n CCONJ dpc-4458 255 18 , , PUNCT dpc-4458 255 19 thompson thompson PROPN dpc-4458 255 20 j. j. PROPN dpc-4458 255 21 a a DET dpc-4458 255 22 framework framework NOUN dpc-4458 255 23 for for ADP dpc-4458 255 24 the the DET dpc-4458 255 25 investigation investigation NOUN dpc-4458 255 26 of of ADP dpc-4458 255 27 pleiotropy pleiotropy NOUN dpc-4458 255 28 in in ADP dpc-4458 255 29 two two NUM dpc-4458 255 30 - - PUNCT dpc-4458 255 31 sample sample NOUN dpc-4458 255 32 summary summary NOUN dpc-4458 255 33 data datum NOUN dpc-4458 255 34 mendelian mendelian ADJ dpc-4458 255 35 randomization randomization NOUN dpc-4458 255 36 . . PUNCT dpc-4458 256 1 stat stat PROPN dpc-4458 256 2 med med PROPN dpc-4458 256 3 . . PUNCT dpc-4458 257 1 2017;36(11):1783 2017;36(11):1783 NUM dpc-4458 257 2 - - SYM dpc-4458 257 3 1802 1802 NUM dpc-4458 257 4 . . PUNCT dpc-4458 258 1 doi doi NOUN dpc-4458 258 2 : : PUNCT dpc-4458 258 3 10.1002 10.1002 NUM dpc-4458 258 4 / / SYM dpc-4458 258 5 sim.7221 sim.7221 NOUN dpc-4458 258 6 . . PUNCT dpc-4458 259 1 pmid pmid NOUN dpc-4458 259 2 : : PUNCT dpc-4458 259 3 28114746 28114746 NUM dpc-4458 259 4 . . PUNCT dpc-4458 260 1 16 16 NUM dpc-4458 260 2 . . PUNCT dpc-4458 261 1 boef boef PROPN dpc-4458 261 2 agc agc PROPN dpc-4458 261 3 , , PUNCT dpc-4458 261 4 dekkers dekker NOUN dpc-4458 261 5 om om PROPN dpc-4458 261 6 , , PUNCT dpc-4458 261 7 le le X dpc-4458 261 8 cessie cessie PROPN dpc-4458 261 9 s. s. PROPN dpc-4458 261 10 mendelian mendelian PROPN dpc-4458 261 11 randomization randomization NOUN dpc-4458 261 12 studies study NOUN dpc-4458 261 13 : : PUNCT dpc-4458 261 14 a a DET dpc-4458 261 15 review review NOUN dpc-4458 261 16 of of ADP dpc-4458 261 17 the the DET dpc-4458 261 18 approaches approach NOUN dpc-4458 261 19 used use VERB dpc-4458 261 20 and and CCONJ dpc-4458 261 21 the the DET dpc-4458 261 22 quality quality NOUN dpc-4458 261 23 of of ADP dpc-4458 261 24 reporting reporting NOUN dpc-4458 261 25 . . PUNCT dpc-4458 262 1 int int NOUN dpc-4458 262 2 j j PROPN dpc-4458 262 3 epidemiol epidemiol PROPN dpc-4458 262 4 . . PUNCT dpc-4458 263 1 2015;44(2):496 2015;44(2):496 PROPN dpc-4458 263 2 - - PUNCT dpc-4458 263 3 511 511 NUM dpc-4458 263 4 . . PUNCT dpc-4458 264 1 doi doi NOUN dpc-4458 264 2 : : PUNCT dpc-4458 264 3 10.1093 10.1093 NUM dpc-4458 264 4 / / SYM dpc-4458 264 5 ije ije PROPN dpc-4458 264 6 /dyv071 /dyv071 PROPN dpc-4458 264 7 . . PUNCT dpc-4458 265 1 pmid pmid NOUN dpc-4458 265 2 : : PUNCT dpc-4458 265 3 25953784 25953784 NUM dpc-4458 265 4 . . PUNCT dpc-4458 266 1 in in ADP dpc-4458 266 2 three three NUM dpc-4458 266 3 different different ADJ dpc-4458 266 4 gwas gwas NOUN dpc-4458 266 5 databases database NOUN dpc-4458 266 6 ; ; PUNCT dpc-4458 266 7 we we PRON dpc-4458 266 8 analyzed analyze VERB dpc-4458 266 9 the the DET dpc-4458 266 10 causal causal PROPN dpc-4458 266 11 association association NOUN dpc-4458 266 12 between between ADP dpc-4458 266 13 the the DET dpc-4458 266 14 three three NUM dpc-4458 266 15 individual individual ADJ dpc-4458 266 16 cohorts cohort NOUN dpc-4458 266 17 ( ( PUNCT dpc-4458 266 18 exposure exposure NOUN dpc-4458 266 19 ) ) PUNCT dpc-4458 266 20 and and CCONJ dpc-4458 266 21 the the DET dpc-4458 266 22 bp bp PROPN dpc-4458 266 23 ( ( PUNCT dpc-4458 266 24 outcome outcome NOUN dpc-4458 266 25 ) ) PUNCT dpc-4458 266 26 . . PUNCT dpc-4458 267 1 interestingly interestingly ADV dpc-4458 267 2 , , PUNCT dpc-4458 267 3 these these DET dpc-4458 267 4 three three NUM dpc-4458 267 5 cohorts cohort NOUN dpc-4458 267 6 obtained obtain VERB dpc-4458 267 7 similar similar ADJ dpc-4458 267 8 results result NOUN dpc-4458 267 9 , , PUNCT dpc-4458 267 10 namely namely ADV dpc-4458 267 11 that that DET dpc-4458 267 12 psoriasis psoriasis NOUN dpc-4458 267 13 has have VERB dpc-4458 267 14 a a DET dpc-4458 267 15 causal causal ADJ dpc-4458 267 16 impact impact NOUN dpc-4458 267 17 on on ADP dpc-4458 267 18 bp bp PROPN dpc-4458 267 19 . . PUNCT dpc-4458 268 1 these these DET dpc-4458 268 2 analyses analysis NOUN dpc-4458 268 3 enhance enhance VERB dpc-4458 268 4 the the DET dpc-4458 268 5 robustness robustness NOUN dpc-4458 268 6 of of ADP dpc-4458 268 7 our our PRON dpc-4458 268 8 outcomes outcome NOUN dpc-4458 268 9 . . PUNCT dpc-4458 269 1 limitations limitation NOUN dpc-4458 269 2 there there PRON dpc-4458 269 3 are be VERB dpc-4458 269 4 several several ADJ dpc-4458 269 5 limitations limitation NOUN dpc-4458 269 6 to to ADP dpc-4458 269 7 our our PRON dpc-4458 269 8     SPACE dpc-4458 269 9 study study NOUN dpc-4458 269 10 . . PUNCT dpc-4458 270 1 first first ADV dpc-4458 270 2 , , PUNCT dpc-4458 270 3 we we PRON dpc-4458 270 4 were be AUX dpc-4458 270 5 unable unable ADJ dpc-4458 270 6 to to PART dpc-4458 270 7 divide divide VERB dpc-4458 270 8 the the DET dpc-4458 270 9 cohorts cohort NOUN dpc-4458 270 10 or or CCONJ dpc-4458 270 11 perform perform VERB dpc-4458 270 12 subgroup subgroup NOUN dpc-4458 270 13 analyses analysis NOUN dpc-4458 270 14 due due ADP dpc-4458 270 15 to to ADP dpc-4458 270 16 the the DET dpc-4458 270 17 original original ADJ dpc-4458 270 18 gwas gwas NOUN dpc-4458 270 19 statistics statistic NOUN dpc-4458 270 20 . . PUNCT dpc-4458 271 1 second second ADJ dpc-4458 271 2 , , PUNCT dpc-4458 271 3     SPACE dpc-4458 271 4 our our PRON dpc-4458 271 5 mr mr PROPN dpc-4458 271 6 analysis analysis NOUN dpc-4458 271 7 only only ADV dpc-4458 271 8 included include VERB dpc-4458 271 9 individuals individual NOUN dpc-4458 271 10 of of ADP dpc-4458 271 11 the the DET dpc-4458 271 12 european european ADJ dpc-4458 271 13 population population NOUN dpc-4458 271 14 . . PUNCT dpc-4458 272 1 as as ADP dpc-4458 272 2 using use VERB dpc-4458 272 3 a a DET dpc-4458 272 4 single single ADJ dpc-4458 272 5 european european ADJ dpc-4458 272 6 population population NOUN dpc-4458 272 7 in in ADP dpc-4458 272 8 our our PRON dpc-4458 272 9 mr mr PROPN dpc-4458 272 10 analysis analysis NOUN dpc-4458 272 11 can can AUX dpc-4458 272 12 limit limit VERB dpc-4458 272 13 population population NOUN dpc-4458 272 14 stratification stratification NOUN dpc-4458 272 15 bias bias NOUN dpc-4458 272 16 , , PUNCT dpc-4458 272 17 caution caution NOUN dpc-4458 272 18 is be AUX dpc-4458 272 19 needed need VERB dpc-4458 272 20 when when SCONJ dpc-4458 272 21 interpreting interpret VERB dpc-4458 272 22 these these DET dpc-4458 272 23 findings finding NOUN dpc-4458 272 24 and and CCONJ dpc-4458 272 25 their their PRON dpc-4458 272 26 applicability applicability NOUN dpc-4458 272 27 to to ADP dpc-4458 272 28 different different ADJ dpc-4458 272 29 populations population NOUN dpc-4458 272 30 . . PUNCT dpc-4458 273 1 third third ADV dpc-4458 273 2 , , PUNCT dpc-4458 273 3 our our PRON dpc-4458 273 4 results result NOUN dpc-4458 273 5 indicated indicate VERB dpc-4458 273 6 that that SCONJ dpc-4458 273 7 psoriasis psoriasis NOUN dpc-4458 273 8 has have VERB dpc-4458 273 9 a a DET dpc-4458 273 10 causal causal ADJ dpc-4458 273 11 influence influence NOUN dpc-4458 273 12 on on ADP dpc-4458 273 13 bp bp PROPN dpc-4458 273 14 . . PUNCT dpc-4458 274 1 there there PRON dpc-4458 274 2 was be VERB dpc-4458 274 3 no no DET dpc-4458 274 4 evidence evidence NOUN dpc-4458 274 5 that that PRON dpc-4458 274 6 bp bp PROPN dpc-4458 274 7 itself itself PRON dpc-4458 274 8 was be AUX dpc-4458 274 9 a a DET dpc-4458 274 10 casual casual ADJ dpc-4458 274 11 risk risk NOUN dpc-4458 274 12 to to ADP dpc-4458 274 13 psoriasis psoriasis NOUN dpc-4458 274 14 , , PUNCT dpc-4458 274 15 but but CCONJ dpc-4458 274 16 this this PRON dpc-4458 274 17 does do AUX dpc-4458 274 18 not not PART dpc-4458 274 19 mean mean VERB dpc-4458 274 20 bp bp PROPN dpc-4458 274 21 had have VERB dpc-4458 274 22 no no DET dpc-4458 274 23 impact impact NOUN dpc-4458 274 24 on on ADP dpc-4458 274 25 psoriasis psoriasis NOUN dpc-4458 274 26 . . PUNCT dpc-4458 275 1 the the DET dpc-4458 275 2 fundamental fundamental ADJ dpc-4458 275 3 mechanisms mechanism NOUN dpc-4458 275 4 and and CCONJ dpc-4458 275 5 pathways pathway NOUN dpc-4458 275 6 that that PRON dpc-4458 275 7 contribute contribute VERB dpc-4458 275 8 to to ADP dpc-4458 275 9 the the DET dpc-4458 275 10 causal causal ADJ dpc-4458 275 11 relationship relationship NOUN dpc-4458 275 12 between between ADP dpc-4458 275 13 psoriasis psoriasis NOUN dpc-4458 275 14 and and CCONJ dpc-4458 275 15 bp bp PROPN dpc-4458 275 16 require require VERB dpc-4458 275 17 further further ADJ dpc-4458 275 18 investigation investigation NOUN dpc-4458 275 19 and and CCONJ dpc-4458 275 20 clarification clarification NOUN dpc-4458 275 21 . . PUNCT dpc-4458 276 1 as as SCONJ dpc-4458 276 2 previously previously ADV dpc-4458 276 3 mentioned mention VERB dpc-4458 276 4 , , PUNCT dpc-4458 276 5 mr mr PROPN dpc-4458 276 6 analysis analysis NOUN dpc-4458 276 7 can can AUX dpc-4458 276 8 be be AUX dpc-4458 276 9 conducted conduct VERB dpc-4458 276 10 using use VERB dpc-4458 276 11 only only ADJ dpc-4458 276 12 summary summary NOUN dpc-4458 276 13 data datum NOUN dpc-4458 276 14 , , PUNCT dpc-4458 276 15 i.e. i.e. X dpc-4458 276 16 , , PUNCT dpc-4458 276 17 it it PRON dpc-4458 276 18 is be AUX dpc-4458 276 19 unnecessary unnecessary ADJ dpc-4458 276 20 to to PART dpc-4458 276 21 use use VERB dpc-4458 276 22 individual individual ADJ dpc-4458 276 23 level level NOUN dpc-4458 276 24 data datum NOUN dpc-4458 277 1 [ [ X dpc-4458 277 2 14 14 NUM dpc-4458 277 3 ] ] PUNCT dpc-4458 277 4 . . PUNCT dpc-4458 278 1 inverse inverse NOUN dpc-4458 278 2 - - PUNCT dpc-4458 278 3 variance variance NOUN dpc-4458 278 4 weighted weight VERB dpc-4458 278 5 two two NUM dpc-4458 278 6 - - PUNCT dpc-4458 278 7 sample sample NOUN dpc-4458 278 8 mendelian mendelian ADJ dpc-4458 278 9 randomization randomization NOUN dpc-4458 278 10 ( ( PUNCT dpc-4458 278 11 ivw ivw NOUN dpc-4458 278 12 - - PUNCT dpc-4458 278 13 mr mr NOUN dpc-4458 278 14 ) ) PUNCT dpc-4458 278 15 is be AUX dpc-4458 278 16 the the DET dpc-4458 278 17 most most ADV dpc-4458 278 18 commonly commonly ADV dpc-4458 278 19 used use VERB dpc-4458 278 20 approach approach NOUN dpc-4458 278 21 that that PRON dpc-4458 278 22 utilizes utilize VERB dpc-4458 278 23 genome genome NOUN dpc-4458 278 24 - - PUNCT dpc-4458 278 25 wide wide ADJ dpc-4458 278 26 association association NOUN dpc-4458 278 27 studies study NOUN dpc-4458 278 28 ( ( PUNCT dpc-4458 278 29 gwas gwas PROPN dpc-4458 278 30 ) ) PUNCT dpc-4458 278 31 summary summary NOUN dpc-4458 278 32 statistics statistic NOUN dpc-4458 278 33 to to PART dpc-4458 278 34 infer infer VERB dpc-4458 278 35 the the DET dpc-4458 278 36 existence existence NOUN dpc-4458 278 37 and and CCONJ dpc-4458 278 38 the the DET dpc-4458 278 39 strength strength NOUN dpc-4458 278 40 of of ADP dpc-4458 278 41 the the DET dpc-4458 278 42 causal causal ADJ dpc-4458 278 43 effect effect NOUN dpc-4458 278 44 between between ADP dpc-4458 278 45 an an DET dpc-4458 278 46 exposure exposure NOUN dpc-4458 278 47 and and CCONJ dpc-4458 278 48 an an DET dpc-4458 278 49 outcome outcome NOUN dpc-4458 278 50 . . PUNCT dpc-4458 279 1 in in ADP dpc-4458 279 2 addition addition NOUN dpc-4458 279 3 , , PUNCT dpc-4458 279 4 two two NUM dpc-4458 279 5 - - PUNCT dpc-4458 279 6 sample sample NOUN dpc-4458 279 7 mr mr PROPN dpc-4458 279 8 methods method NOUN dpc-4458 279 9 expect expect VERB dpc-4458 279 10 the the DET dpc-4458 279 11 exposure exposure NOUN dpc-4458 279 12 and and CCONJ dpc-4458 279 13 the the DET dpc-4458 279 14 outcome outcome NOUN dpc-4458 279 15 gwas gwas NOUN dpc-4458 279 16 summary summary NOUN dpc-4458 279 17 statistics statistic NOUN dpc-4458 279 18 to to PART dpc-4458 279 19 be be AUX dpc-4458 279 20 obtained obtain VERB dpc-4458 279 21 from from ADP dpc-4458 279 22 independent independent ADJ dpc-4458 279 23 samples sample NOUN dpc-4458 279 24 . . PUNCT dpc-4458 280 1 estimates estimate NOUN dpc-4458 280 2 from from ADP dpc-4458 280 3 this this DET dpc-4458 280 4 method method NOUN dpc-4458 280 5 can can AUX dpc-4458 280 6 be be AUX dpc-4458 280 7 biased bias VERB dpc-4458 280 8 due due ADJ dpc-4458 280 9 to to ADP dpc-4458 280 10 weak weak ADJ dpc-4458 280 11 instruments instrument NOUN dpc-4458 280 12 and and CCONJ dpc-4458 280 13 to to ADP dpc-4458 280 14 the the DET dpc-4458 280 15 winner winner NOUN dpc-4458 280 16 ’s ’s PART dpc-4458 280 17 curse curse NOUN dpc-4458 280 18 , , PUNCT dpc-4458 280 19 which which PRON dpc-4458 280 20 can can AUX dpc-4458 280 21 change change VERB dpc-4458 280 22 as as ADP dpc-4458 280 23 a a DET dpc-4458 280 24 function function NOUN dpc-4458 280 25 of of ADP dpc-4458 280 26 the the DET dpc-4458 280 27 overlap overlap NOUN dpc-4458 280 28 between between ADP dpc-4458 280 29 the the DET dpc-4458 280 30 exposure exposure NOUN dpc-4458 280 31 and and CCONJ dpc-4458 280 32 outcome outcome NOUN dpc-4458 280 33 samples sample NOUN dpc-4458 280 34 . . PUNCT dpc-4458 281 1 it it PRON dpc-4458 281 2 should should AUX dpc-4458 281 3 be be AUX dpc-4458 281 4 noted note VERB dpc-4458 281 5 that that SCONJ dpc-4458 281 6 the the DET dpc-4458 281 7 method method NOUN dpc-4458 281 8 we we PRON dpc-4458 281 9 used use VERB dpc-4458 281 10 may may AUX dpc-4458 281 11 bias bias VERB dpc-4458 281 12 our our PRON dpc-4458 281 13 results result NOUN dpc-4458 281 14 [ [ X dpc-4458 281 15 13 13 NUM dpc-4458 281 16 , , PUNCT dpc-4458 281 17 14 14 NUM dpc-4458 281 18 ] ] PUNCT dpc-4458 281 19 . . PUNCT dpc-4458 282 1 conclusion conclusion NOUN dpc-4458 282 2 our our PRON dpc-4458 282 3 mr mr PROPN dpc-4458 282 4 analysis analysis NOUN dpc-4458 282 5 provides provide VERB dpc-4458 282 6 evidence evidence NOUN dpc-4458 282 7 that that SCONJ dpc-4458 282 8 psoriasis psoriasis NOUN dpc-4458 282 9 has have AUX dpc-4458 282 10 a a DET dpc-4458 282 11 causal causal ADJ dpc-4458 282 12 impact impact NOUN dpc-4458 282 13 on on ADP dpc-4458 282 14 bp bp PROPN dpc-4458 282 15 . . PUNCT dpc-4458 282 16     SPACE dpc-4458 283 1 our our PRON dpc-4458 283 2 findings finding NOUN dpc-4458 283 3 indicate indicate VERB dpc-4458 283 4 that that SCONJ dpc-4458 283 5 we we PRON dpc-4458 283 6 should should AUX dpc-4458 283 7 pay pay VERB dpc-4458 283 8 attention attention NOUN dpc-4458 283 9 to to ADP dpc-4458 283 10 the the DET dpc-4458 283 11 possibility possibility NOUN dpc-4458 283 12 of of ADP dpc-4458 283 13 bp bp PROPN dpc-4458 283 14 development development NOUN dpc-4458 283 15 so so SCONJ dpc-4458 283 16 as as SCONJ dpc-4458 283 17 to to PART dpc-4458 283 18 improve improve VERB dpc-4458 283 19 treatment treatment NOUN dpc-4458 283 20 strategies strategy NOUN dpc-4458 283 21 for for ADP dpc-4458 283 22 patients patient NOUN dpc-4458 283 23 with with ADP dpc-4458 283 24 psoriasis psoriasis NOUN dpc-4458 283 25 . . PUNCT dpc-4458 284 1 further further ADJ dpc-4458 284 2 investigations investigation NOUN dpc-4458 284 3 are be AUX dpc-4458 284 4 required require VERB dpc-4458 284 5 to to PART dpc-4458 284 6 elucidate elucidate VERB dpc-4458 284 7 the the DET dpc-4458 284 8 underlying underlie VERB dpc-4458 284 9 mechanisms mechanism NOUN dpc-4458 284 10 between between ADP dpc-4458 284 11 the the DET dpc-4458 284 12 contributing contribute VERB dpc-4458 284 13 risk risk NOUN dpc-4458 284 14 factors factor NOUN dpc-4458 284 15 of of ADP dpc-4458 284 16 psoriasis psoriasis NOUN dpc-4458 284 17 to to AUX dpc-4458 284 18 bp bp PROPN dpc-4458 284 19 . . PUNCT dpc-4458 285 1 references reference NOUN dpc-4458 285 2 1 1 NUM dpc-4458 285 3 . . PUNCT dpc-4458 286 1 guo guo PROPN dpc-4458 286 2 j j PROPN dpc-4458 286 3 , , PUNCT dpc-4458 286 4 zhang zhang PROPN dpc-4458 286 5 h h PROPN dpc-4458 286 6 , , PUNCT dpc-4458 286 7 lin lin PROPN dpc-4458 286 8 w w PROPN dpc-4458 286 9 , , PUNCT dpc-4458 286 10 lu lu PROPN dpc-4458 286 11 l l NOUN dpc-4458 286 12 , , PUNCT dpc-4458 286 13 su su PROPN dpc-4458 286 14 j j PROPN dpc-4458 286 15 , , PUNCT dpc-4458 286 16 chen chen PROPN dpc-4458 286 17 x. x. PROPN dpc-4458 286 18 signaling signal VERB dpc-4458 286 19 pathways pathway NOUN dpc-4458 286 20 and and CCONJ dpc-4458 286 21 targeted target VERB dpc-4458 286 22 therapies therapy NOUN dpc-4458 286 23 for for ADP dpc-4458 286 24 psoriasis psoriasis NOUN dpc-4458 286 25 . . PUNCT dpc-4458 287 1 signal signal VERB dpc-4458 287 2 8 8 NUM dpc-4458 287 3 original original ADJ dpc-4458 287 4 article article NOUN dpc-4458 287 5 | | ADV dpc-4458 287 6 dermatol dermatol ADJ dpc-4458 287 7 pract pract NOUN dpc-4458 287 8 concept concept NOUN dpc-4458 287 9 . . PUNCT dpc-4458 288 1 2025;15(1):4458 2025;15(1):4458 ADJ dpc-4458 288 2 27 27 NUM dpc-4458 288 3 . . PUNCT dpc-4458 289 1 korman korman PROPN dpc-4458 289 2 nj nj PROPN dpc-4458 289 3 . . PUNCT dpc-4458 290 1 management management NOUN dpc-4458 290 2 of of ADP dpc-4458 290 3 psoriasis psoriasis NOUN dpc-4458 290 4 as as ADP dpc-4458 290 5 a a DET dpc-4458 290 6 systemic systemic ADJ dpc-4458 290 7 disease disease NOUN dpc-4458 290 8 : : PUNCT dpc-4458 290 9 what what PRON dpc-4458 290 10 is be AUX dpc-4458 290 11 the the DET dpc-4458 290 12 evidence evidence NOUN dpc-4458 290 13 ? ? PUNCT dpc-4458 291 1 br br PROPN dpc-4458 291 2 j j PROPN dpc-4458 291 3 dermatol dermatol NOUN dpc-4458 291 4 . . PUNCT dpc-4458 292 1 2019;182(4):840 2019;182(4):840 NUM dpc-4458 292 2 - - SYM dpc-4458 292 3 848 848 NUM dpc-4458 292 4 . . PUNCT dpc-4458 292 5 doi doi NOUN dpc-4458 292 6 : : PUNCT dpc-4458 292 7 10.1111 10.1111 NUM dpc-4458 292 8 / / SYM dpc-4458 292 9 bjd.18245 bjd.18245 PROPN dpc-4458 292 10 . . PUNCT dpc-4458 293 1 pmid pmid NOUN dpc-4458 293 2 : : PUNCT dpc-4458 293 3 31225638 31225638 NUM dpc-4458 293 4 . . PUNCT dpc-4458 294 1 28 28 NUM dpc-4458 294 2 . . PUNCT dpc-4458 295 1 vikár vikár PROPN dpc-4458 295 2 s s PROPN dpc-4458 295 3 , , PUNCT dpc-4458 295 4 szilveszter szilveszter NOUN dpc-4458 295 5 kp kp PROPN dpc-4458 295 6 , , PUNCT dpc-4458 295 7 koszorú koszorú PROPN dpc-4458 295 8 k k PROPN dpc-4458 295 9 , , PUNCT dpc-4458 295 10 sárdy sárdy VERB dpc-4458 295 11 m m PROPN dpc-4458 295 12 , , PUNCT dpc-4458 295 13 mócsai mócsai PROPN dpc-4458 295 14 a. a. NOUN dpc-4458 295 15 the the DET dpc-4458 295 16 syk syk PROPN dpc-4458 295 17 inhibitor inhibitor NOUN dpc-4458 295 18 entospletinib entospletinib NOUN dpc-4458 295 19 abolishes abolish VERB dpc-4458 295 20 dermal dermal NOUN dpc-4458 295 21 - - PUNCT dpc-4458 295 22 epidermal epidermal ADJ dpc-4458 295 23 separation separation NOUN dpc-4458 295 24 in in ADP dpc-4458 295 25 a a DET dpc-4458 295 26 fully fully ADV dpc-4458 295 27 human human ADJ dpc-4458 295 28 ex ex X dpc-4458 295 29 vivo vivo NOUN dpc-4458 295 30 model model NOUN dpc-4458 295 31 of of ADP dpc-4458 295 32 bullous bullous ADJ dpc-4458 295 33 pemphigoid pemphigoid NOUN dpc-4458 295 34 . . PUNCT dpc-4458 296 1 j j PROPN dpc-4458 296 2 invest invest VERB dpc-4458 296 3 dermatol dermatol NOUN dpc-4458 296 4 . . PUNCT dpc-4458 297 1 2024;144(8):1733 2024;144(8):1733 NUM dpc-4458 297 2 - - SYM dpc-4458 297 3 1742 1742 NUM dpc-4458 297 4 . . PUNCT dpc-4458 298 1 doi doi NOUN dpc-4458 298 2 : : PUNCT dpc-4458 298 3 10.1016 10.1016 NUM dpc-4458 298 4 / / SYM dpc-4458 298 5 j. j. PROPN dpc-4458 298 6 jid.2024.01.009 jid.2024.01.009 PROPN dpc-4458 298 7 . . PUNCT dpc-4458 299 1 pmid pmid NOUN dpc-4458 299 2 : : PUNCT dpc-4458 299 3 38296021 38296021 NUM dpc-4458 299 4 . . PUNCT dpc-4458 300 1 29 29 NUM dpc-4458 300 2 . . PUNCT dpc-4458 300 3 díaz díaz PROPN dpc-4458 300 4 la la PROPN dpc-4458 300 5 , , PUNCT dpc-4458 300 6 ratrie ratrie ADJ dpc-4458 300 7 h h NOUN dpc-4458 300 8 , , PUNCT dpc-4458 300 9 saunders saunders PROPN dpc-4458 300 10 ws ws PROPN dpc-4458 300 11 , , PUNCT dpc-4458 300 12 et et PROPN dpc-4458 300 13 al al PROPN dpc-4458 300 14 . . PUNCT dpc-4458 300 15 isolation isolation NOUN dpc-4458 300 16 of of ADP dpc-4458 300 17 a a DET dpc-4458 300 18 human human ADJ dpc-4458 300 19 epidermal epidermal ADJ dpc-4458 300 20 cdna cdna NOUN dpc-4458 300 21 corresponding corresponding NOUN dpc-4458 300 22 to to ADP dpc-4458 300 23 the the DET dpc-4458 300 24 180 180 NUM dpc-4458 300 25 - - PUNCT dpc-4458 300 26 kd kd PROPN dpc-4458 300 27 autoantigen autoantigen PROPN dpc-4458 300 28 recognized recognize VERB dpc-4458 300 29 by by ADP dpc-4458 300 30 bullous bullous ADJ dpc-4458 300 31 pemphigoid pemphigoid NOUN dpc-4458 300 32 and and CCONJ dpc-4458 300 33 herpes herpe NOUN dpc-4458 300 34 gestationis gestationis PROPN dpc-4458 300 35 sera sera NOUN dpc-4458 300 36 . . PUNCT dpc-4458 301 1 immunolocalization immunolocalization NOUN dpc-4458 301 2 of of ADP dpc-4458 301 3 this this DET dpc-4458 301 4 protein protein NOUN dpc-4458 301 5 to to ADP dpc-4458 301 6 the the DET dpc-4458 301 7 hemidesmosome hemidesmosome NOUN dpc-4458 301 8 . . PUNCT dpc-4458 302 1 j j PROPN dpc-4458 302 2 clin clin PROPN dpc-4458 302 3 invest invest PROPN dpc-4458 302 4 . . PUNCT dpc-4458 303 1 1990;86(4):1088 1990;86(4):1088 NUM dpc-4458 303 2 - - PUNCT dpc-4458 303 3 1094 1094 NUM dpc-4458 303 4 . . PUNCT dpc-4458 304 1 doi doi NOUN dpc-4458 304 2 : : PUNCT dpc-4458 304 3 10.1172 10.1172 NUM dpc-4458 304 4 / / SYM dpc-4458 304 5 jci114812 jci114812 NOUN dpc-4458 304 6 . . PUNCT dpc-4458 305 1 pmid pmid NOUN dpc-4458 305 2 : : PUNCT dpc-4458 305 3 1698819 1698819 NUM dpc-4458 305 4 . . PUNCT dpc-4458 306 1 30 30 NUM dpc-4458 306 2 . . PUNCT dpc-4458 306 3 stanley stanley PROPN dpc-4458 306 4 jr jr PROPN dpc-4458 306 5 , , PUNCT dpc-4458 306 6 hawley hawley PROPN dpc-4458 306 7 - - PUNCT dpc-4458 306 8 nelson nelson PROPN dpc-4458 306 9 p p PROPN dpc-4458 306 10 , , PUNCT dpc-4458 306 11 yuspa yuspa PROPN dpc-4458 306 12 sh sh PROPN dpc-4458 306 13 , , PUNCT dpc-4458 306 14 shevach shevach VERB dpc-4458 306 15 em em PRON dpc-4458 306 16 , , PUNCT dpc-4458 306 17 katz katz PROPN dpc-4458 306 18 si si PROPN dpc-4458 306 19 . . PROPN dpc-4458 306 20 characterization characterization NOUN dpc-4458 306 21 of of ADP dpc-4458 306 22 bullous bullous ADJ dpc-4458 306 23 pemphigoid pemphigoid ADJ dpc-4458 306 24 antigen antigen NOUN dpc-4458 306 25 : : PUNCT dpc-4458 306 26 a a DET dpc-4458 306 27 unique unique ADJ dpc-4458 306 28 basement basement NOUN dpc-4458 306 29 membrane membrane NOUN dpc-4458 306 30 protein protein NOUN dpc-4458 306 31 of of ADP dpc-4458 306 32 stratified stratified ADJ dpc-4458 306 33 squamous squamous ADJ dpc-4458 306 34 epithelia epithelia NOUN dpc-4458 306 35 . . PUNCT dpc-4458 307 1 cell cell NOUN dpc-4458 307 2 . . PUNCT dpc-4458 308 1 1981;24(3):897 1981;24(3):897 NUM dpc-4458 308 2 - - PUNCT dpc-4458 308 3 903 903 NUM dpc-4458 308 4 . . PUNCT dpc-4458 309 1 doi doi NOUN dpc-4458 309 2 : : PUNCT dpc-4458 309 3 10.1016/0092 10.1016/0092 NUM dpc-4458 309 4 - - SYM dpc-4458 309 5 8674(81)90115 8674(81)90115 NUM dpc-4458 309 6 - - PUNCT dpc-4458 309 7 x. x. NOUN dpc-4458 309 8 pmid pmid PROPN dpc-4458 309 9 : : PUNCT dpc-4458 309 10 7018697 7018697 NUM dpc-4458 309 11 . . PUNCT dpc-4458 310 1 31 31 NUM dpc-4458 310 2 . . PUNCT dpc-4458 311 1 schmidt schmidt PROPN dpc-4458 311 2 ee ee PROPN dpc-4458 311 3 , , PUNCT dpc-4458 311 4 reimer reimer PROPN dpc-4458 311 5 s s PROPN dpc-4458 311 6 , , PUNCT dpc-4458 311 7 jainta jainta PROPN dpc-4458 311 8 s s PROPN dpc-4458 311 9 , , PUNCT dpc-4458 311 10 et et PROPN dpc-4458 311 11 al al PROPN dpc-4458 311 12 . . PROPN dpc-4458 311 13 autoantibodies autoantibody NOUN dpc-4458 311 14 to to ADP dpc-4458 311 15 bp180 bp180 PROPN dpc-4458 311 16 associated associate VERB dpc-4458 311 17 with with ADP dpc-4458 311 18 bullous bullous ADJ dpc-4458 311 19 pemphigoid pemphigoid ADJ dpc-4458 311 20 release release NOUN dpc-4458 311 21 interleukin-6 interleukin-6 NUM dpc-4458 311 22 and and CCONJ dpc-4458 311 23 interleukin-8 interleukin-8 NUM dpc-4458 311 24 from from ADP dpc-4458 311 25 cultured cultured ADJ dpc-4458 311 26 human human ADJ dpc-4458 311 27 keratinocytes keratinocyte NOUN dpc-4458 311 28 . . PUNCT dpc-4458 312 1 j j PROPN dpc-4458 312 2 invest invest VERB dpc-4458 312 3 dermatol dermatol NOUN dpc-4458 312 4 . . PUNCT dpc-4458 313 1 2000;115(5):842 2000;115(5):842 NUM dpc-4458 313 2 - - SYM dpc-4458 313 3 848 848 NUM dpc-4458 314 1 . . PUNCT dpc-4458 314 2 doi doi NOUN dpc-4458 314 3 : : PUNCT dpc-4458 314 4 10.1046 10.1046 NUM dpc-4458 314 5 / / SYM dpc-4458 314 6 j.1523 j.1523 NOUN dpc-4458 314 7 - - PUNCT dpc-4458 314 8 1747 1747 NUM dpc-4458 314 9 .2000.00141.x .2000.00141.x NOUN dpc-4458 314 10 . . PUNCT dpc-4458 315 1 pmid pmid NOUN dpc-4458 315 2 : : PUNCT dpc-4458 315 3 11069622 11069622 NUM dpc-4458 315 4 . . PUNCT dpc-4458 316 1 32 32 NUM dpc-4458 316 2 . . PUNCT dpc-4458 317 1 kridin kridin VERB dpc-4458 317 2 k k PROPN dpc-4458 317 3 , , PUNCT dpc-4458 317 4 bergman bergman PROPN dpc-4458 317 5 r. r. PROPN dpc-4458 317 6 association association PROPN dpc-4458 317 7 between between ADP dpc-4458 317 8 bullous bullous ADJ dpc-4458 317 9 pemphigoid pemphigoid NOUN dpc-4458 317 10 and and CCONJ dpc-4458 317 11 psoriasis psoriasis NOUN dpc-4458 317 12 : : PUNCT dpc-4458 317 13 a a DET dpc-4458 317 14 case case NOUN dpc-4458 317 15 - - PUNCT dpc-4458 317 16 control control NOUN dpc-4458 317 17 study study NOUN dpc-4458 317 18 . . PUNCT dpc-4458 318 1 j j PROPN dpc-4458 318 2 am be AUX dpc-4458 318 3 acad acad ADJ dpc-4458 318 4 dermatol dermatol NOUN dpc-4458 318 5 . . PUNCT dpc-4458 319 1 2017;77(2):370 2017;77(2):370 NUM dpc-4458 319 2 - - SYM dpc-4458 319 3 372 372 NUM dpc-4458 319 4 . . PUNCT dpc-4458 319 5 doi doi NOUN dpc-4458 319 6 : : PUNCT dpc-4458 319 7 10.1016 10.1016 NUM dpc-4458 319 8 / / SYM dpc-4458 319 9 j.jaad.2017.02.057 j.jaad.2017.02.057 PROPN dpc-4458 319 10 . . PUNCT dpc-4458 320 1 pmid pmid NOUN dpc-4458 320 2 : : PUNCT dpc-4458 320 3 28711088 28711088 NUM dpc-4458 320 4 . . PUNCT dpc-4458 321 1 33 33 NUM dpc-4458 321 2 . . PUNCT dpc-4458 321 3 phan phan PROPN dpc-4458 321 4 k k PROPN dpc-4458 321 5 , , PUNCT dpc-4458 321 6 goyal goyal PROPN dpc-4458 321 7 s s PROPN dpc-4458 321 8 , , PUNCT dpc-4458 321 9 murrell murrell PROPN dpc-4458 321 10 df df PROPN dpc-4458 321 11 . . PUNCT dpc-4458 321 12 association association PROPN dpc-4458 321 13 between between ADP dpc-4458 321 14 bullous bullous ADJ dpc-4458 321 15 pemphigoid pemphigoid NOUN dpc-4458 321 16 and and CCONJ dpc-4458 321 17 psoriasis psoriasis NOUN dpc-4458 321 18 : : PUNCT dpc-4458 321 19 systematic systematic ADJ dpc-4458 321 20 review review NOUN dpc-4458 321 21 and and CCONJ dpc-4458 321 22 meta meta ADJ dpc-4458 321 23 - - PUNCT dpc-4458 321 24 analysis analysis NOUN dpc-4458 321 25 of of ADP dpc-4458 321 26 case case NOUN dpc-4458 321 27 - - PUNCT dpc-4458 321 28 control control NOUN dpc-4458 321 29 studies study NOUN dpc-4458 321 30 . . PUNCT dpc-4458 322 1 australas australas PROPN dpc-4458 322 2 j j PROPN dpc-4458 322 3 dermatol dermatol NOUN dpc-4458 322 4 . . PUNCT dpc-4458 323 1 2018;60(1):23 2018;60(1):23 NUM dpc-4458 323 2 - - SYM dpc-4458 323 3 28 28 NUM dpc-4458 323 4 . . PUNCT dpc-4458 324 1 doi doi NOUN dpc-4458 324 2 : : PUNCT dpc-4458 324 3 10.1111 10.1111 NUM dpc-4458 324 4 / / SYM dpc-4458 324 5 ajd.12899 ajd.12899 PROPN dpc-4458 324 6 . . PUNCT dpc-4458 325 1 pmid pmid NOUN dpc-4458 325 2 : : PUNCT dpc-4458 325 3 30141189 30141189 NUM dpc-4458 325 4 . . PUNCT dpc-4458 326 1 34 34 NUM dpc-4458 326 2 . . PUNCT dpc-4458 327 1 su su PROPN dpc-4458 327 2 f f PROPN dpc-4458 327 3 , , PUNCT dpc-4458 327 4 wang wang PROPN dpc-4458 327 5 t t PROPN dpc-4458 327 6 , , PUNCT dpc-4458 327 7 qin qin PROPN dpc-4458 328 1 q q PROPN dpc-4458 328 2 , , PUNCT dpc-4458 328 3 xie xie PROPN dpc-4458 328 4 z. z. PROPN dpc-4458 328 5 upadacitinib upadacitinib NOUN dpc-4458 328 6 for for ADP dpc-4458 328 7 the the DET dpc-4458 328 8 management management NOUN dpc-4458 328 9 of of ADP dpc-4458 328 10 bullous bullous ADJ dpc-4458 328 11 pemphigoid pemphigoid NOUN dpc-4458 328 12 coexisting coexist VERB dpc-4458 328 13 with with ADP dpc-4458 328 14 psoriasis psoriasis NOUN dpc-4458 328 15 vulgaris vulgaris NOUN dpc-4458 328 16 : : PUNCT dpc-4458 328 17 a a DET dpc-4458 328 18 case case NOUN dpc-4458 328 19 report report NOUN dpc-4458 328 20 and and CCONJ dpc-4458 328 21 literature literature NOUN dpc-4458 328 22 review review PROPN dpc-4458 328 23 . . PUNCT dpc-4458 329 1 j j PROPN dpc-4458 329 2 dermatol dermatol NOUN dpc-4458 329 3 treat treat NOUN dpc-4458 329 4 . . PUNCT dpc-4458 330 1 2024;35(1):e2302394 2024;35(1):e2302394 X dpc-4458 330 2 . . X dpc-4458 330 3 doi doi NOUN dpc-4458 330 4 : : PUNCT dpc-4458 330 5 10.1080/09546634.2024.2302394 10.1080/09546634.2024.2302394 NUM dpc-4458 330 6 . . PUNCT dpc-4458 331 1 pmid pmid NOUN dpc-4458 331 2 : : PUNCT dpc-4458 331 3 38263708 38263708 NUM dpc-4458 331 4 . . PUNCT dpc-4458 332 1 35 35 NUM dpc-4458 332 2 . . PUNCT dpc-4458 333 1 ho ho PROPN dpc-4458 333 2 ph ph PROPN dpc-4458 333 3 , , PUNCT dpc-4458 333 4 tsai tsai PROPN dpc-4458 333 5 tf tf PROPN dpc-4458 333 6 . . PUNCT dpc-4458 334 1 development development NOUN dpc-4458 334 2 of of ADP dpc-4458 334 3 bullous bullous ADJ dpc-4458 334 4 pemphigoid pemphigoid NOUN dpc-4458 334 5 during during ADP dpc-4458 334 6 secukinumab secukinumab NOUN dpc-4458 334 7 treatment treatment NOUN dpc-4458 334 8 for for ADP dpc-4458 334 9 psoriasis psoriasis NOUN dpc-4458 334 10 . . PUNCT dpc-4458 335 1 j j PROPN dpc-4458 335 2 dermatol dermatol NOUN dpc-4458 335 3 . . PUNCT dpc-4458 336 1 2017;44(9):e220 2017;44(9):e220 X dpc-4458 336 2 - - PUNCT dpc-4458 336 3 e221 e221 PROPN dpc-4458 336 4 . . PUNCT dpc-4458 336 5 doi doi NOUN dpc-4458 336 6 : : PUNCT dpc-4458 336 7 10.1111/1346 10.1111/1346 NUM dpc-4458 336 8 - - SYM dpc-4458 336 9 8138.13909 8138.13909 NOUN dpc-4458 336 10 . . PUNCT dpc-4458 337 1 pmid pmid NOUN dpc-4458 337 2 : : PUNCT dpc-4458 337 3 28543960 28543960 NUM dpc-4458 337 4 . . PUNCT dpc-4458 338 1 17 17 NUM dpc-4458 338 2 . . PUNCT dpc-4458 339 1 sakaue sakaue PROPN dpc-4458 339 2 s s PROPN dpc-4458 339 3 , , PUNCT dpc-4458 339 4 kanai kanai PROPN dpc-4458 339 5 m m PROPN dpc-4458 339 6 , , PUNCT dpc-4458 339 7 tanigawa tanigawa PROPN dpc-4458 339 8 y y PROPN dpc-4458 339 9 , , PUNCT dpc-4458 339 10 et et PROPN dpc-4458 339 11 al al PROPN dpc-4458 339 12 . . PUNCT dpc-4458 340 1 a a DET dpc-4458 340 2 cross cross ADJ dpc-4458 340 3 - - ADJ dpc-4458 340 4 population population ADJ dpc-4458 340 5 atlas atla NOUN dpc-4458 340 6 of of ADP dpc-4458 340 7 genetic genetic ADJ dpc-4458 340 8 associations association NOUN dpc-4458 340 9 for for ADP dpc-4458 340 10 220 220 NUM dpc-4458 340 11 human human ADJ dpc-4458 340 12 phenotypes phenotype NOUN dpc-4458 340 13 . . PUNCT dpc-4458 341 1 nat nat PROPN dpc-4458 341 2 genet genet PROPN dpc-4458 341 3 . . PUNCT dpc-4458 342 1 2021;53(10):1415 2021;53(10):1415 NUM dpc-4458 342 2 - - SYM dpc-4458 342 3 1424 1424 NUM dpc-4458 342 4 . . PUNCT dpc-4458 343 1 doi doi NOUN dpc-4458 343 2 : : PUNCT dpc-4458 343 3 10.1038 10.1038 NUM dpc-4458 343 4 / / SYM dpc-4458 343 5 s41588 s41588 VERB dpc-4458 343 6 - - PUNCT dpc-4458 343 7 021 021 NUM dpc-4458 343 8 - - PUNCT dpc-4458 343 9 00931 00931 NUM dpc-4458 343 10 - - PUNCT dpc-4458 343 11 x. x. NOUN dpc-4458 343 12 pmid pmid PROPN dpc-4458 343 13 : : PUNCT dpc-4458 343 14 34594039 34594039 NUM dpc-4458 343 15 . . PUNCT dpc-4458 344 1 18 18 NUM dpc-4458 344 2 . . PUNCT dpc-4458 345 1 bowden bowden PROPN dpc-4458 345 2 j j PROPN dpc-4458 345 3 , , PUNCT dpc-4458 345 4 davey davey PROPN dpc-4458 345 5 smith smith PROPN dpc-4458 345 6 g g PROPN dpc-4458 345 7 , , PUNCT dpc-4458 345 8 burgess burgess PROPN dpc-4458 345 9 s. s. PROPN dpc-4458 345 10 mendelian mendelian PROPN dpc-4458 345 11 randomization randomization NOUN dpc-4458 345 12 with with ADP dpc-4458 345 13 invalid invalid ADJ dpc-4458 345 14 instruments instrument NOUN dpc-4458 345 15 : : PUNCT dpc-4458 345 16 effect effect VERB dpc-4458 345 17 estimation estimation NOUN dpc-4458 345 18 and and CCONJ dpc-4458 345 19 bias bias NOUN dpc-4458 345 20 detection detection NOUN dpc-4458 345 21 through through ADP dpc-4458 345 22 egger egger NOUN dpc-4458 345 23 regression regression NOUN dpc-4458 345 24 . . PUNCT dpc-4458 346 1 int int NOUN dpc-4458 346 2 j j PROPN dpc-4458 346 3 epidemiol epidemiol PROPN dpc-4458 346 4 . . PUNCT dpc-4458 347 1 2015;44(2):512 2015;44(2):512 PROPN dpc-4458 347 2 - - SYM dpc-4458 347 3 525 525 NUM dpc-4458 347 4 . . PUNCT dpc-4458 348 1 doi doi NOUN dpc-4458 348 2 : : PUNCT dpc-4458 348 3 10.1093 10.1093 NUM dpc-4458 348 4 / / SYM dpc-4458 348 5 ije ije NOUN dpc-4458 348 6 / / SYM dpc-4458 348 7 dyv080 dyv080 PROPN dpc-4458 348 8 . . PUNCT dpc-4458 349 1 pmid pmid NOUN dpc-4458 349 2 : : PUNCT dpc-4458 349 3 26050253 26050253 NUM dpc-4458 349 4 . . PUNCT dpc-4458 350 1 19 19 NUM dpc-4458 350 2 . . PUNCT dpc-4458 351 1 armstrong armstrong PROPN dpc-4458 351 2 aw aw PROPN dpc-4458 351 3 , , PUNCT dpc-4458 351 4 read read VERB dpc-4458 351 5 c. c. PROPN dpc-4458 351 6 pathophysiology pathophysiology NOUN dpc-4458 351 7 , , PUNCT dpc-4458 351 8 clinical clinical ADJ dpc-4458 351 9 presentation presentation NOUN dpc-4458 351 10 , , PUNCT dpc-4458 351 11 and and CCONJ dpc-4458 351 12 treatment treatment NOUN dpc-4458 351 13 of of ADP dpc-4458 351 14 psoriasis psoriasis NOUN dpc-4458 351 15 . . PUNCT dpc-4458 352 1 jama jama NOUN dpc-4458 352 2 . . PUNCT dpc-4458 353 1 2020;323(19):1945 2020;323(19):1945 X dpc-4458 353 2 . . PUNCT dpc-4458 353 3 doi doi NOUN dpc-4458 353 4 : : PUNCT dpc-4458 353 5 10.1001 10.1001 NUM dpc-4458 353 6 / / SYM dpc-4458 353 7 jama.2020.4006 jama.2020.4006 PROPN dpc-4458 353 8 . . PUNCT dpc-4458 354 1 pmid pmid NOUN dpc-4458 354 2 : : PUNCT dpc-4458 354 3 32427307 32427307 NUM dpc-4458 354 4 . . PUNCT dpc-4458 355 1 20 20 NUM dpc-4458 355 2 . . PUNCT dpc-4458 356 1 conrad conrad PROPN dpc-4458 356 2 c c PROPN dpc-4458 356 3 , , PUNCT dpc-4458 356 4 gilliet gilliet ADJ dpc-4458 356 5 m. m. NOUN dpc-4458 356 6 psoriasis psoriasis NOUN dpc-4458 356 7 : : PUNCT dpc-4458 356 8 from from ADP dpc-4458 356 9 pathogenesis pathogenesis NOUN dpc-4458 356 10 to to ADP dpc-4458 356 11 targeted target VERB dpc-4458 356 12 therapies therapy NOUN dpc-4458 356 13 . . PUNCT dpc-4458 357 1 clin clin PROPN dpc-4458 357 2 rev rev PROPN dpc-4458 357 3 allergy allergy PROPN dpc-4458 357 4 immunol immunol NOUN dpc-4458 357 5 . . PUNCT dpc-4458 358 1 2018;54(1):102 2018;54(1):102 NUM dpc-4458 358 2 - - PUNCT dpc-4458 358 3 113 113 NUM dpc-4458 358 4 . . PUNCT dpc-4458 359 1 doi doi NOUN dpc-4458 359 2 : : PUNCT dpc-4458 359 3 10.1007 10.1007 NUM dpc-4458 359 4 / / SYM dpc-4458 359 5 s12016 s12016 PROPN dpc-4458 359 6 - - PUNCT dpc-4458 359 7 018 018 NUM dpc-4458 359 8 - - PUNCT dpc-4458 359 9 8668 8668 NUM dpc-4458 359 10 - - SYM dpc-4458 359 11 1 1 NUM dpc-4458 359 12 . . PUNCT dpc-4458 360 1 pmid pmid NOUN dpc-4458 360 2 : : PUNCT dpc-4458 360 3 29349534 29349534 NUM dpc-4458 360 4 . . PUNCT dpc-4458 361 1 21 21 NUM dpc-4458 361 2 . . PUNCT dpc-4458 362 1 teng teng PROPN dpc-4458 362 2 mwl mwl PROPN dpc-4458 362 3 , , PUNCT dpc-4458 362 4 bowman bowman PROPN dpc-4458 362 5 ep ep PROPN dpc-4458 362 6 , , PUNCT dpc-4458 362 7 mcelwee mcelwee PROPN dpc-4458 362 8 jj jj PROPN dpc-4458 362 9 , , PUNCT dpc-4458 362 10 et et PROPN dpc-4458 362 11 al al PROPN dpc-4458 362 12 . . PROPN dpc-4458 362 13 il-12 il-12 NOUN dpc-4458 362 14 and and CCONJ dpc-4458 362 15 il-23 il-23 NOUN dpc-4458 362 16 cytokines cytokine NOUN dpc-4458 362 17 : : PUNCT dpc-4458 362 18 from from ADP dpc-4458 362 19 discovery discovery NOUN dpc-4458 362 20 to to ADP dpc-4458 362 21 targeted target VERB dpc-4458 362 22 therapies therapy NOUN dpc-4458 362 23 for for ADP dpc-4458 362 24 immune immune ADJ dpc-4458 362 25 mediated mediate VERB dpc-4458 362 26 inflammatory inflammatory ADJ dpc-4458 362 27 diseases disease NOUN dpc-4458 362 28 . . PUNCT dpc-4458 363 1 nat nat PROPN dpc-4458 363 2 med med PROPN dpc-4458 363 3 . . PUNCT dpc-4458 364 1 2015;21(7):719 2015;21(7):719 NUM dpc-4458 364 2 - - SYM dpc-4458 364 3 729 729 NUM dpc-4458 364 4 . . PUNCT dpc-4458 365 1 doi doi NOUN dpc-4458 365 2 : : PUNCT dpc-4458 365 3 10.1038 10.1038 NUM dpc-4458 365 4 / / SYM dpc-4458 365 5 nm.3895 nm.3895 PROPN dpc-4458 365 6 . . PUNCT dpc-4458 366 1 pmid pmid PROPN dpc-4458 366 2 : : PUNCT dpc-4458 366 3 26121196 26121196 NUM dpc-4458 366 4 . . PUNCT dpc-4458 367 1 22 22 NUM dpc-4458 367 2 . . PUNCT dpc-4458 368 1 martin martin PROPN dpc-4458 368 2 da da PROPN dpc-4458 368 3 , , PUNCT dpc-4458 368 4 towne towne PROPN dpc-4458 368 5 je je PROPN dpc-4458 368 6 , , PUNCT dpc-4458 368 7 kricorian kricorian PROPN dpc-4458 368 8 g g PROPN dpc-4458 368 9 , , PUNCT dpc-4458 368 10 et et PROPN dpc-4458 368 11 al al PROPN dpc-4458 368 12 . . PUNCT dpc-4458 369 1 the the DET dpc-4458 369 2 emerging emerge VERB dpc-4458 369 3 role role NOUN dpc-4458 369 4 of of ADP dpc-4458 369 5 il-17 il-17 NUM dpc-4458 369 6 in in ADP dpc-4458 369 7 the the DET dpc-4458 369 8 pathogenesis pathogenesis NOUN dpc-4458 369 9 of of ADP dpc-4458 369 10 psoriasis psoriasis NOUN dpc-4458 369 11 : : PUNCT dpc-4458 369 12 preclinical preclinical ADJ dpc-4458 369 13 and and CCONJ dpc-4458 369 14 clinical clinical ADJ dpc-4458 369 15 findings finding NOUN dpc-4458 369 16 . . PUNCT dpc-4458 370 1 j j PROPN dpc-4458 370 2 invest invest VERB dpc-4458 370 3 dermatol dermatol NOUN dpc-4458 370 4 . . PUNCT dpc-4458 371 1 2013;133(1):17 2013;133(1):17 VERB dpc-4458 371 2 - - PUNCT dpc-4458 371 3 26 26 NUM dpc-4458 371 4 . . PUNCT dpc-4458 372 1 doi doi NOUN dpc-4458 372 2 : : PUNCT dpc-4458 372 3 10.1038 10.1038 NUM dpc-4458 372 4 / / SYM dpc-4458 372 5 jid jid PROPN dpc-4458 372 6 .2012.194 .2012.194 X dpc-4458 372 7 . . PUNCT dpc-4458 373 1 pmid pmid NOUN dpc-4458 373 2 : : PUNCT dpc-4458 373 3 22673731 22673731 NUM dpc-4458 373 4 . . PUNCT dpc-4458 374 1 23 23 NUM dpc-4458 374 2 . . PUNCT dpc-4458 374 3 hu hu PROPN dpc-4458 375 1 p p PROPN dpc-4458 375 2 , , PUNCT dpc-4458 375 3 wang wang PROPN dpc-4458 375 4 m m PROPN dpc-4458 375 5 , , PUNCT dpc-4458 375 6 gao gao PROPN dpc-4458 375 7 h h PROPN dpc-4458 375 8 , , PUNCT dpc-4458 375 9 et et PROPN dpc-4458 375 10 al al PROPN dpc-4458 375 11 . . PUNCT dpc-4458 376 1 the the DET dpc-4458 376 2 role role NOUN dpc-4458 376 3 of of ADP dpc-4458 376 4 helper helper NOUN dpc-4458 376 5 t t NOUN dpc-4458 376 6 cells cell NOUN dpc-4458 376 7 in in ADP dpc-4458 376 8 psoriasis psoriasis NOUN dpc-4458 376 9 . . PUNCT dpc-4458 377 1 front front ADJ dpc-4458 377 2 immunol immunol NOUN dpc-4458 377 3 . . PUNCT dpc-4458 378 1 2021;12:788940 2021;12:788940 X dpc-4458 378 2 . . PUNCT dpc-4458 378 3 doi doi NOUN dpc-4458 378 4 : : PUNCT dpc-4458 378 5 10.3389 10.3389 NUM dpc-4458 378 6 / / SYM dpc-4458 378 7 fimmu.2021 fimmu.2021 PROPN dpc-4458 378 8 .788940 .788940 PROPN dpc-4458 378 9 . . PUNCT dpc-4458 379 1 pmid pmid NOUN dpc-4458 379 2 : : PUNCT dpc-4458 379 3 34975883 34975883 NUM dpc-4458 379 4 . . PUNCT dpc-4458 380 1 24 24 NUM dpc-4458 380 2 . . PUNCT dpc-4458 381 1 zhou zhou PROPN dpc-4458 381 2 x x PROPN dpc-4458 381 3 , , PUNCT dpc-4458 381 4 chen chen PROPN dpc-4458 381 5 y y PROPN dpc-4458 381 6 , , PUNCT dpc-4458 381 7 cui cui PROPN dpc-4458 381 8 l l PROPN dpc-4458 381 9 , , PUNCT dpc-4458 381 10 shi shi PROPN dpc-4458 381 11 y y PROPN dpc-4458 381 12 , , PUNCT dpc-4458 381 13 guo guo PROPN dpc-4458 381 14 c. c. PROPN dpc-4458 381 15 advances advance VERB dpc-4458 381 16 in in ADP dpc-4458 381 17 the the DET dpc-4458 381 18 pathogenesis pathogenesis NOUN dpc-4458 381 19 of of ADP dpc-4458 381 20 psoriasis psoriasis NOUN dpc-4458 381 21 : : PUNCT dpc-4458 381 22 from from ADP dpc-4458 381 23 keratinocyte keratinocyte PROPN dpc-4458 381 24 perspective perspective NOUN dpc-4458 381 25 . . PUNCT dpc-4458 382 1 cell cell NOUN dpc-4458 382 2 death death NOUN dpc-4458 382 3 dis dis PROPN dpc-4458 382 4 . . PUNCT dpc-4458 383 1 2022;13(1):81 2022;13(1):81 NUM dpc-4458 383 2 . . PUNCT dpc-4458 384 1 doi doi NOUN dpc-4458 384 2 : : PUNCT dpc-4458 384 3 10.1038 10.1038 NUM dpc-4458 384 4 / / SYM dpc-4458 384 5 s41419 s41419 NUM dpc-4458 384 6 - - NOUN dpc-4458 384 7 022 022 NUM dpc-4458 384 8 - - PUNCT dpc-4458 384 9 04523 04523 NUM dpc-4458 384 10 - - SYM dpc-4458 384 11 3 3 NUM dpc-4458 384 12 . . PUNCT dpc-4458 385 1 pmid pmid NOUN dpc-4458 385 2 : : PUNCT dpc-4458 385 3 35075118 35075118 NUM dpc-4458 385 4 . . PUNCT dpc-4458 386 1 25 25 NUM dpc-4458 386 2 . . PUNCT dpc-4458 387 1 krueger krueger PROPN dpc-4458 387 2 jg jg PROPN dpc-4458 387 3 , , PUNCT dpc-4458 387 4 mcinnes mcinnes PROPN dpc-4458 387 5 ib ib PROPN dpc-4458 387 6 , , PUNCT dpc-4458 387 7 blauvelt blauvelt PROPN dpc-4458 387 8 a. a. NOUN dpc-4458 387 9 tyrosine tyrosine PROPN dpc-4458 387 10 kinase kinase PROPN dpc-4458 387 11 2 2 NUM dpc-4458 387 12 and and CCONJ dpc-4458 387 13 janus janus PROPN dpc-4458 387 14 kinase kinase PROPN dpc-4458 387 15 – – PUNCT dpc-4458 387 16 signal signal NOUN dpc-4458 387 17 transducer transducer NOUN dpc-4458 387 18 and and CCONJ dpc-4458 387 19 activator activator NOUN dpc-4458 387 20 of of ADP dpc-4458 387 21 transcription transcription NOUN dpc-4458 387 22 signaling signal VERB dpc-4458 387 23 and and CCONJ dpc-4458 387 24 inhibition inhibition NOUN dpc-4458 387 25 in in ADP dpc-4458 387 26 plaque plaque NOUN dpc-4458 387 27 psoriasis psoriasis NOUN dpc-4458 387 28 . . PUNCT dpc-4458 388 1 j j PROPN dpc-4458 388 2 am be AUX dpc-4458 388 3 acad acad ADJ dpc-4458 388 4 dermatol dermatol NOUN dpc-4458 388 5 . . PUNCT dpc-4458 389 1 2022;86(1):148 2022;86(1):148 NUM dpc-4458 389 2 - - PUNCT dpc-4458 389 3 157 157 NUM dpc-4458 389 4 . . PUNCT dpc-4458 390 1 doi doi NOUN dpc-4458 390 2 : : PUNCT dpc-4458 390 3 10.1016 10.1016 NUM dpc-4458 390 4 / / SYM dpc-4458 390 5 j.jaad.2021.06.869 j.jaad.2021.06.869 PROPN dpc-4458 390 6 . . PUNCT dpc-4458 391 1 pmid pmid NOUN dpc-4458 391 2 : : PUNCT dpc-4458 391 3 34224773 34224773 NUM dpc-4458 391 4 . . PUNCT dpc-4458 392 1 26 26 NUM dpc-4458 392 2 . . PUNCT dpc-4458 393 1 liang liang PROPN dpc-4458 393 2 j j PROPN dpc-4458 393 3 , , PUNCT dpc-4458 393 4 chen chen PROPN dpc-4458 393 5 p p PROPN dpc-4458 393 6 , , PUNCT dpc-4458 393 7 li li PROPN dpc-4458 393 8 c c PROPN dpc-4458 393 9 , , PUNCT dpc-4458 393 10 et et PROPN dpc-4458 393 11 al al PROPN dpc-4458 393 12 . . PROPN dpc-4458 393 13 il-22 il-22 ADP dpc-4458 393 14 down down ADV dpc-4458 393 15 - - PUNCT dpc-4458 393 16 regulates regulate VERB dpc-4458 393 17 cx43 cx43 PROPN dpc-4458 393 18 expression expression NOUN dpc-4458 393 19 and and CCONJ dpc-4458 393 20 decreases decrease VERB dpc-4458 393 21 gap gap NOUN dpc-4458 393 22 junctional junctional ADJ dpc-4458 393 23 intercellular intercellular ADJ dpc-4458 393 24 communication communication NOUN dpc-4458 393 25 by by ADP dpc-4458 393 26 activating activate VERB dpc-4458 393 27 the the DET dpc-4458 393 28 jnk jnk PROPN dpc-4458 393 29 pathway pathway NOUN dpc-4458 393 30 in in ADP dpc-4458 393 31 psoriasis psoriasis NOUN dpc-4458 393 32 . . PUNCT dpc-4458 394 1 j j PROPN dpc-4458 394 2 invest invest VERB dpc-4458 394 3 dermatol dermatol NOUN dpc-4458 394 4 . . PUNCT dpc-4458 395 1 2019;139(2):400 2019;139(2):400 NUM dpc-4458 395 2 - - SYM dpc-4458 395 3 411 411 NUM dpc-4458 395 4 . . PUNCT dpc-4458 396 1 doi doi NOUN dpc-4458 396 2 : : PUNCT dpc-4458 396 3 10.1016 10.1016 NUM dpc-4458 396 4 / / SYM dpc-4458 396 5 j.jid.2018.07.032 j.jid.2018.07.032 PROPN dpc-4458 396 6 . . PUNCT dpc-4458 397 1 pmid pmid NOUN dpc-4458 397 2 : : PUNCT dpc-4458 397 3 30171832 30171832 NUM dpc-4458 397 4 . . PUNCT