id	sid	tid	token	lemma	pos
dpc-4596	1	1	dermatology	dermatology	NOUN
dpc-4596	1	2	:	:	PUNCT
dpc-4596	1	3	practical	practical	ADJ
dpc-4596	1	4	and	and	CCONJ
dpc-4596	1	5	conceptual	conceptual	ADJ
dpc-4596	1	6	original	original	ADJ
dpc-4596	1	7	article	article	NOUN
dpc-4596	1	8	|	|	ADV
dpc-4596	1	9	dermatol	dermatol	ADJ
dpc-4596	1	10	pract	pract	NOUN
dpc-4596	1	11	concept	concept	NOUN
dpc-4596	1	12	.	.	PUNCT
dpc-4596	2	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	2	2	1	1	NUM
dpc-4596	2	3	mtorc1	mtorc1	NOUN
dpc-4596	2	4	 	 	SPACE
dpc-4596	2	5	and	and	CCONJ
dpc-4596	2	6	mtorc2	mtorc2	NOUN
dpc-4596	2	7	levels	level	NOUN
dpc-4596	2	8	in	in	ADP
dpc-4596	2	9	patients	patient	NOUN
dpc-4596	2	10	with	with	ADP
dpc-4596	2	11	psoriasis	psoriasis	NOUN
dpc-4596	2	12	i̇layda	i̇layda	NUM
dpc-4596	2	13	esna	esna	PROPN
dpc-4596	2	14	gülsunay1	gülsunay1	PROPN
dpc-4596	2	15	,	,	PUNCT
dpc-4596	2	16	i̇lknur	i̇lknur	VERB
dpc-4596	2	17	altunay1	altunay1	PROPN
dpc-4596	2	18	,	,	PUNCT
dpc-4596	2	19	tuğba	tuğba	PROPN
dpc-4596	2	20	kum2	kum2	PROPN
dpc-4596	2	21	,	,	PUNCT
dpc-4596	2	22	aslı	aslı	NOUN
dpc-4596	2	23	aksu	aksu	NOUN
dpc-4596	2	24	çerman1	çerman1	PROPN
dpc-4596	3	1	1	1	NUM
dpc-4596	3	2	university	university	NOUN
dpc-4596	3	3	of	of	ADP
dpc-4596	3	4	health	health	PROPN
dpc-4596	3	5	sciences	sciences	PROPN
dpc-4596	3	6	,	,	PUNCT
dpc-4596	3	7	şişli	şişli	NOUN
dpc-4596	3	8	hamidiye	hamidiye	NOUN
dpc-4596	3	9	etfal	etfal	NOUN
dpc-4596	3	10	training	training	NOUN
dpc-4596	3	11	and	and	CCONJ
dpc-4596	3	12	research	research	NOUN
dpc-4596	3	13	hospital	hospital	NOUN
dpc-4596	3	14	,	,	PUNCT
dpc-4596	3	15	dermatology	dermatology	NOUN
dpc-4596	3	16	department	department	NOUN
dpc-4596	3	17	,	,	PUNCT
dpc-4596	3	18	seyrantepe	seyrantepe	NOUN
dpc-4596	3	19	,	,	PUNCT
dpc-4596	3	20	i̇stanbul	i̇stanbul	INTJ
dpc-4596	3	21	,	,	PUNCT
dpc-4596	3	22	turkey	turkey	PROPN
dpc-4596	3	23	2	2	NUM
dpc-4596	3	24	university	university	NOUN
dpc-4596	3	25	of	of	ADP
dpc-4596	3	26	health	health	PROPN
dpc-4596	3	27	sciences	sciences	PROPN
dpc-4596	3	28	,	,	PUNCT
dpc-4596	3	29	şişli	şişli	NOUN
dpc-4596	3	30	hamidiye	hamidiye	NOUN
dpc-4596	3	31	etfal	etfal	NOUN
dpc-4596	3	32	training	training	NOUN
dpc-4596	3	33	and	and	CCONJ
dpc-4596	3	34	research	research	NOUN
dpc-4596	3	35	hospital	hospital	NOUN
dpc-4596	3	36	,	,	PUNCT
dpc-4596	3	37	biochemistry	biochemistry	NOUN
dpc-4596	3	38	department	department	PROPN
dpc-4596	3	39	,	,	PUNCT
dpc-4596	3	40	seyrantepe	seyrantepe	NOUN
dpc-4596	3	41	,	,	PUNCT
dpc-4596	3	42	i̇stanbul	i̇stanbul	ADV
dpc-4596	3	43	,	,	PUNCT
dpc-4596	3	44	turkey	turkey	PROPN
dpc-4596	3	45	key	key	ADJ
dpc-4596	3	46	words	word	NOUN
dpc-4596	3	47	:	:	PUNCT
dpc-4596	3	48	psoriasis	psoriasis	NOUN
dpc-4596	3	49	,	,	PUNCT
dpc-4596	3	50	mtorcs	mtorcs	NOUN
dpc-4596	3	51	citation	citation	NOUN
dpc-4596	3	52	:	:	PUNCT
dpc-4596	3	53	gülsunay	gülsunay	PROPN
dpc-4596	3	54	i̇e	i̇e	PROPN
dpc-4596	3	55	,	,	PUNCT
dpc-4596	3	56	altunay	altunay	NOUN
dpc-4596	3	57	i̇	i̇	PROPN
dpc-4596	3	58	,	,	PUNCT
dpc-4596	3	59	kum	kum	PROPN
dpc-4596	3	60	t	t	PROPN
dpc-4596	3	61	,	,	PUNCT
dpc-4596	3	62	çerman	çerman	ADJ
dpc-4596	3	63	aa	aa	PROPN
dpc-4596	3	64	.	.	PUNCT
dpc-4596	4	1	mtorc1	mtorc1	NOUN
dpc-4596	4	2	and	and	CCONJ
dpc-4596	4	3	mtorc2	mtorc2	PROPN
dpc-4596	4	4	levels	level	NOUN
dpc-4596	4	5	in	in	ADP
dpc-4596	4	6	patients	patient	NOUN
dpc-4596	4	7	with	with	ADP
dpc-4596	4	8	psoriasis	psoriasis	NOUN
dpc-4596	4	9	.	.	PUNCT
dpc-4596	5	1	dermatol	dermatol	NOUN
dpc-4596	5	2	pract	pract	PROPN
dpc-4596	5	3	concept	concept	NOUN
dpc-4596	5	4	.	.	PUNCT
dpc-4596	6	1	2024;14(4):e2024266	2024;14(4):e2024266	X
dpc-4596	6	2	.	.	X
dpc-4596	7	1	doi	doi	NOUN
dpc-4596	7	2	:	:	PUNCT
dpc-4596	7	3	https://doi.org/10.5826/dpc.1404a266	https://doi.org/10.5826/dpc.1404a266	NOUN
dpc-4596	7	4	accepted	accept	VERB
dpc-4596	7	5	:	:	PUNCT
dpc-4596	7	6	june	june	PROPN
dpc-4596	7	7	24	24	NUM
dpc-4596	7	8	,	,	PUNCT
dpc-4596	7	9	2024	2024	NUM
dpc-4596	7	10	;	;	PUNCT
dpc-4596	7	11	published	publish	VERB
dpc-4596	7	12	:	:	PUNCT
dpc-4596	8	1	october	october	PROPN
dpc-4596	8	2	2024	2024	NUM
dpc-4596	8	3	copyright	copyright	NOUN
dpc-4596	8	4	:	:	PUNCT
dpc-4596	8	5	©	©	PROPN
dpc-4596	8	6	2024	2024	NUM
dpc-4596	8	7	gülsunay	gülsunay	NOUN
dpc-4596	8	8	et	et	PROPN
dpc-4596	8	9	al	al	PROPN
dpc-4596	8	10	.	.	PUNCT
dpc-4596	9	1	this	this	PRON
dpc-4596	9	2	is	be	AUX
dpc-4596	9	3	an	an	DET
dpc-4596	9	4	open	open	ADJ
dpc-4596	9	5	-	-	PUNCT
dpc-4596	9	6	access	access	NOUN
dpc-4596	9	7	article	article	NOUN
dpc-4596	9	8	distributed	distribute	VERB
dpc-4596	9	9	under	under	ADP
dpc-4596	9	10	the	the	DET
dpc-4596	9	11	terms	term	NOUN
dpc-4596	9	12	of	of	ADP
dpc-4596	9	13	the	the	DET
dpc-4596	9	14	creative	creative	ADJ
dpc-4596	9	15	commons	common	NOUN
dpc-4596	9	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-4596	9	17	license	license	NOUN
dpc-4596	9	18	(	(	PUNCT
dpc-4596	9	19	by	by	ADP
dpc-4596	9	20	-	-	PUNCT
dpc-4596	9	21	nc-4.0	nc-4.0	NOUN
dpc-4596	9	22	)	)	PUNCT
dpc-4596	9	23	,	,	PUNCT
dpc-4596	9	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-4596	9	25	,	,	PUNCT
dpc-4596	9	26	which	which	PRON
dpc-4596	9	27	permits	permit	VERB
dpc-4596	9	28	unrestricted	unrestricted	ADJ
dpc-4596	9	29	noncommercial	noncommercial	ADJ
dpc-4596	9	30	use	use	NOUN
dpc-4596	9	31	,	,	PUNCT
dpc-4596	9	32	distribution	distribution	NOUN
dpc-4596	9	33	,	,	PUNCT
dpc-4596	9	34	and	and	CCONJ
dpc-4596	9	35	reproduction	reproduction	NOUN
dpc-4596	9	36	in	in	ADP
dpc-4596	9	37	any	any	DET
dpc-4596	9	38	medium	medium	NOUN
dpc-4596	9	39	,	,	PUNCT
dpc-4596	9	40	provided	provide	VERB
dpc-4596	9	41	the	the	DET
dpc-4596	9	42	original	original	ADJ
dpc-4596	9	43	authors	author	NOUN
dpc-4596	9	44	and	and	CCONJ
dpc-4596	9	45	source	source	NOUN
dpc-4596	9	46	are	be	AUX
dpc-4596	9	47	credited	credit	VERB
dpc-4596	9	48	.	.	PUNCT
dpc-4596	10	1	funding	funding	NOUN
dpc-4596	10	2	:	:	PUNCT
dpc-4596	10	3	none	none	NOUN
dpc-4596	10	4	.	.	PUNCT
dpc-4596	11	1	competing	compete	VERB
dpc-4596	11	2	interests	interest	NOUN
dpc-4596	11	3	:	:	PUNCT
dpc-4596	11	4	none	none	NOUN
dpc-4596	11	5	.	.	PUNCT
dpc-4596	12	1	authorship	authorship	NOUN
dpc-4596	12	2	:	:	PUNCT
dpc-4596	12	3	all	all	DET
dpc-4596	12	4	authors	author	NOUN
dpc-4596	12	5	have	have	AUX
dpc-4596	12	6	contributed	contribute	VERB
dpc-4596	12	7	significantly	significantly	ADV
dpc-4596	12	8	to	to	ADP
dpc-4596	12	9	this	this	DET
dpc-4596	12	10	publication	publication	NOUN
dpc-4596	12	11	.	.	PUNCT
dpc-4596	13	1	corresponding	correspond	VERB
dpc-4596	13	2	author	author	NOUN
dpc-4596	13	3	:	:	PUNCT
dpc-4596	13	4	aslı	aslı	NOUN
dpc-4596	13	5	aksu	aksu	PROPN
dpc-4596	13	6	çerman	çerman	PROPN
dpc-4596	13	7	,	,	PUNCT
dpc-4596	13	8	assoc	assoc	PROPN
dpc-4596	13	9	.	.	PUNCT
dpc-4596	14	1	prof	prof	PROPN
dpc-4596	14	2	.	.	PROPN
dpc-4596	14	3	,	,	PUNCT
dpc-4596	14	4	university	university	PROPN
dpc-4596	14	5	of	of	ADP
dpc-4596	14	6	health	health	PROPN
dpc-4596	14	7	sciences	sciences	PROPN
dpc-4596	14	8	,	,	PUNCT
dpc-4596	14	9	şişli	şişli	NOUN
dpc-4596	14	10	hamidiye	hamidiye	NOUN
dpc-4596	14	11	etfal	etfal	NOUN
dpc-4596	14	12	training	training	NOUN
dpc-4596	14	13	and	and	CCONJ
dpc-4596	14	14	research	research	NOUN
dpc-4596	14	15	hospital	hospital	NOUN
dpc-4596	14	16	,	,	PUNCT
dpc-4596	14	17	dermatology	dermatology	NOUN
dpc-4596	14	18	department	department	NOUN
dpc-4596	14	19	,	,	PUNCT
dpc-4596	14	20	seyrantepe	seyrantepe	NOUN
dpc-4596	14	21	,	,	PUNCT
dpc-4596	14	22	huzur	huzur	PROPN
dpc-4596	14	23	mah	mah	PROPN
dpc-4596	14	24	.	.	PROPN
dpc-4596	14	25	,	,	PUNCT
dpc-4596	14	26	cumhuriyet	cumhuriyet	ADV
dpc-4596	14	27	ve	ve	VERB
dpc-4596	14	28	demokrasi	demokrasi	PROPN
dpc-4596	14	29	cad	cad	PROPN
dpc-4596	14	30	.	.	PROPN
dpc-4596	14	31	,	,	PUNCT
dpc-4596	14	32	no	no	INTJ
dpc-4596	14	33	:	:	SYM
dpc-4596	14	34	1	1	NUM
dpc-4596	14	35	,	,	PUNCT
dpc-4596	14	36	sarıyer	sarıyer	NOUN
dpc-4596	14	37	,	,	PUNCT
dpc-4596	14	38	i̇stanbul	i̇stanbul	ADV
dpc-4596	14	39	,	,	PUNCT
dpc-4596	14	40	turkey	turkey	PROPN
dpc-4596	14	41	.	.	PUNCT
dpc-4596	15	1	phone	phone	NOUN
dpc-4596	15	2	:	:	PUNCT
dpc-4596	15	3	+905426196919	+905426196919	NUM
dpc-4596	15	4	email	email	NOUN
dpc-4596	15	5	:	:	PUNCT
dpc-4596	15	6	aksuasli@hotmail.com	aksuasli@hotmail.com	X
dpc-4596	16	1	introduction	introduction	NOUN
dpc-4596	16	2	:	:	PUNCT
dpc-4596	16	3	in	in	ADP
dpc-4596	16	4	recent	recent	ADJ
dpc-4596	16	5	years	year	NOUN
dpc-4596	16	6	,	,	PUNCT
dpc-4596	16	7	there	there	PRON
dpc-4596	16	8	has	have	AUX
dpc-4596	16	9	been	be	AUX
dpc-4596	16	10	a	a	DET
dpc-4596	16	11	growing	grow	VERB
dpc-4596	16	12	emphasis	emphasis	NOUN
dpc-4596	16	13	on	on	ADP
dpc-4596	16	14	the	the	DET
dpc-4596	16	15	role	role	NOUN
dpc-4596	16	16	of	of	ADP
dpc-4596	16	17	the	the	DET
dpc-4596	16	18	mammalian	mammalian	ADJ
dpc-4596	16	19	target	target	NOUN
dpc-4596	16	20	of	of	ADP
dpc-4596	16	21	rapamycin	rapamycin	NOUN
dpc-4596	16	22	(	(	PUNCT
dpc-4596	16	23	mtor	mtor	NOUN
dpc-4596	16	24	)	)	PUNCT
dpc-4596	16	25	pathway	pathway	NOUN
dpc-4596	16	26	in	in	ADP
dpc-4596	16	27	the	the	DET
dpc-4596	16	28	pathogenesis	pathogenesis	NOUN
dpc-4596	16	29	of	of	ADP
dpc-4596	16	30	psoriasis	psoriasis	NOUN
dpc-4596	16	31	.	.	PUNCT
dpc-4596	17	1	this	this	DET
dpc-4596	17	2	intracellular	intracellular	ADJ
dpc-4596	17	3	signaling	signal	VERB
dpc-4596	17	4	pathway	pathway	NOUN
dpc-4596	17	5	is	be	AUX
dpc-4596	17	6	known	know	VERB
dpc-4596	17	7	as	as	ADP
dpc-4596	17	8	the	the	DET
dpc-4596	17	9	main	main	ADJ
dpc-4596	17	10	control	control	NOUN
dpc-4596	17	11	pathway	pathway	NOUN
dpc-4596	17	12	of	of	ADP
dpc-4596	17	13	metabolism	metabolism	NOUN
dpc-4596	17	14	and	and	CCONJ
dpc-4596	17	15	is	be	AUX
dpc-4596	17	16	of	of	ADP
dpc-4596	17	17	particular	particular	ADJ
dpc-4596	17	18	interest	interest	NOUN
dpc-4596	17	19	in	in	ADP
dpc-4596	17	20	this	this	DET
dpc-4596	17	21	context	context	NOUN
dpc-4596	17	22	.	.	PUNCT
dpc-4596	18	1	objectives	objective	NOUN
dpc-4596	18	2	:	:	PUNCT
dpc-4596	18	3	to	to	PART
dpc-4596	18	4	investigate	investigate	VERB
dpc-4596	18	5	the	the	DET
dpc-4596	18	6	importance	importance	NOUN
dpc-4596	18	7	of	of	ADP
dpc-4596	18	8	the	the	DET
dpc-4596	18	9	mtor	mtor	PROPN
dpc-4596	18	10	pathway	pathway	NOUN
dpc-4596	18	11	in	in	ADP
dpc-4596	18	12	the	the	DET
dpc-4596	18	13	pathogenesis	pathogenesis	NOUN
dpc-4596	18	14	of	of	ADP
dpc-4596	18	15	plaque	plaque	NOUN
dpc-4596	18	16	psoriasis	psoriasis	NOUN
dpc-4596	18	17	.	.	PUNCT
dpc-4596	19	1	methods	method	NOUN
dpc-4596	19	2	:	:	PUNCT
dpc-4596	19	3	a	a	DET
dpc-4596	19	4	total	total	NOUN
dpc-4596	19	5	of	of	ADP
dpc-4596	19	6	forty	forty	NUM
dpc-4596	19	7	patients	patient	NOUN
dpc-4596	19	8	with	with	ADP
dpc-4596	19	9	plaque	plaque	NOUN
dpc-4596	19	10	psoriasis	psoriasis	NOUN
dpc-4596	19	11	and	and	CCONJ
dpc-4596	19	12	40	40	NUM
dpc-4596	19	13	non	non	ADJ
dpc-4596	19	14	-	-	ADJ
dpc-4596	19	15	psoriatic	psoriatic	ADJ
dpc-4596	19	16	volunteers	volunteer	NOUN
dpc-4596	19	17	were	be	AUX
dpc-4596	19	18	included	include	VERB
dpc-4596	19	19	in	in	ADP
dpc-4596	19	20	this	this	DET
dpc-4596	19	21	case	case	NOUN
dpc-4596	19	22	-	-	PUNCT
dpc-4596	19	23	control	control	NOUN
dpc-4596	19	24	study	study	NOUN
dpc-4596	19	25	.	.	PUNCT
dpc-4596	20	1	the	the	DET
dpc-4596	20	2	fasting	fast	VERB
dpc-4596	20	3	serum	serum	NOUN
dpc-4596	20	4	levels	level	NOUN
dpc-4596	20	5	of	of	ADP
dpc-4596	20	6	mtorc1	mtorc1	NOUN
dpc-4596	20	7	and	and	CCONJ
dpc-4596	20	8	mtorc2	mtorc2	PROPN
dpc-4596	20	9	in	in	ADP
dpc-4596	20	10	the	the	DET
dpc-4596	20	11	study	study	NOUN
dpc-4596	20	12	groups	group	NOUN
dpc-4596	20	13	were	be	AUX
dpc-4596	20	14	examined	examine	VERB
dpc-4596	20	15	by	by	ADP
dpc-4596	20	16	enzyme	enzyme	NOUN
dpc-4596	20	17	-	-	PUNCT
dpc-4596	20	18	linked	link	VERB
dpc-4596	20	19	immunosorbent	immunosorbent	NOUN
dpc-4596	20	20	assay	assay	NOUN
dpc-4596	20	21	.	.	PUNCT
dpc-4596	21	1	results	result	NOUN
dpc-4596	21	2	:	:	PUNCT
dpc-4596	21	3	serum	serum	NOUN
dpc-4596	21	4	levels	level	NOUN
dpc-4596	21	5	of	of	ADP
dpc-4596	21	6	both	both	DET
dpc-4596	21	7	mtorc1	mtorc1	NOUN
dpc-4596	21	8	and	and	CCONJ
dpc-4596	21	9	mtorc2	mtorc2	NOUN
dpc-4596	21	10	were	be	AUX
dpc-4596	21	11	found	find	VERB
dpc-4596	21	12	to	to	PART
dpc-4596	21	13	be	be	AUX
dpc-4596	21	14	significantly	significantly	ADV
dpc-4596	21	15	lower	low	ADJ
dpc-4596	21	16	in	in	ADP
dpc-4596	21	17	patients	patient	NOUN
dpc-4596	21	18	with	with	ADP
dpc-4596	21	19	plaque	plaque	NOUN
dpc-4596	21	20	psoriasis	psoriasis	NOUN
dpc-4596	21	21	than	than	ADP
dpc-4596	21	22	in	in	ADP
dpc-4596	21	23	controls	control	NOUN
dpc-4596	21	24	(	(	PUNCT
dpc-4596	21	25	p	p	NOUN
dpc-4596	21	26	=	=	NOUN
dpc-4596	21	27	0.001	0.001	NUM
dpc-4596	21	28	)	)	PUNCT
dpc-4596	21	29	.	.	PUNCT
dpc-4596	22	1	a	a	DET
dpc-4596	22	2	positive	positive	ADJ
dpc-4596	22	3	correlation	correlation	NOUN
dpc-4596	22	4	was	be	AUX
dpc-4596	22	5	identified	identify	VERB
dpc-4596	22	6	between	between	ADP
dpc-4596	22	7	serum	serum	NOUN
dpc-4596	22	8	mtorc1	mtorc1	NOUN
dpc-4596	22	9	and	and	CCONJ
dpc-4596	22	10	serum	serum	PROPN
dpc-4596	22	11	mtorc2	mtorc2	PROPN
dpc-4596	22	12	levels	level	NOUN
dpc-4596	22	13	in	in	ADP
dpc-4596	22	14	patients	patient	NOUN
dpc-4596	22	15	with	with	ADP
dpc-4596	22	16	plaque	plaque	NOUN
dpc-4596	22	17	psoriasis	psoriasis	NOUN
dpc-4596	22	18	(	(	PUNCT
dpc-4596	22	19	p=0.001	p=0.001	NUM
dpc-4596	22	20	,	,	PUNCT
dpc-4596	22	21	r=0.826	r=0.826	NOUN
dpc-4596	22	22	)	)	PUNCT
dpc-4596	22	23	.	.	PUNCT
dpc-4596	23	1	conclusion	conclusion	NOUN
dpc-4596	23	2	:	:	PUNCT
dpc-4596	23	3	the	the	DET
dpc-4596	23	4	lower	low	ADJ
dpc-4596	23	5	serum	serum	NOUN
dpc-4596	23	6	levels	level	NOUN
dpc-4596	23	7	of	of	ADP
dpc-4596	23	8	mtorc1	mtorc1	NOUN
dpc-4596	23	9	and	and	CCONJ
dpc-4596	23	10	mtorc2	mtorc2	NOUN
dpc-4596	23	11	complexes	complex	NOUN
dpc-4596	23	12	,	,	PUNCT
dpc-4596	23	13	which	which	PRON
dpc-4596	23	14	are	be	AUX
dpc-4596	23	15	active	active	ADJ
dpc-4596	23	16	signaling	signal	VERB
dpc-4596	23	17	molecules	molecule	NOUN
dpc-4596	23	18	in	in	ADP
dpc-4596	23	19	the	the	DET
dpc-4596	23	20	cell	cell	NOUN
dpc-4596	23	21	,	,	PUNCT
dpc-4596	23	22	were	be	AUX
dpc-4596	23	23	observed	observe	VERB
dpc-4596	23	24	in	in	ADP
dpc-4596	23	25	patients	patient	NOUN
dpc-4596	23	26	with	with	ADP
dpc-4596	23	27	plaque	plaque	NOUN
dpc-4596	23	28	psoriasis	psoriasis	NOUN
dpc-4596	23	29	.	.	PUNCT
dpc-4596	24	1	this	this	PRON
dpc-4596	24	2	suggests	suggest	VERB
dpc-4596	24	3	that	that	SCONJ
dpc-4596	24	4	these	these	DET
dpc-4596	24	5	levels	level	NOUN
dpc-4596	24	6	may	may	AUX
dpc-4596	24	7	serve	serve	VERB
dpc-4596	24	8	as	as	ADP
dpc-4596	24	9	an	an	DET
dpc-4596	24	10	indicator	indicator	NOUN
dpc-4596	24	11	of	of	ADP
dpc-4596	24	12	increased	increase	VERB
dpc-4596	24	13	intracellular	intracellular	ADJ
dpc-4596	24	14	activation	activation	NOUN
dpc-4596	24	15	of	of	ADP
dpc-4596	24	16	these	these	DET
dpc-4596	24	17	molecules	molecule	NOUN
dpc-4596	24	18	.	.	PUNCT
dpc-4596	25	1	it	it	PRON
dpc-4596	25	2	is	be	AUX
dpc-4596	25	3	our	our	PRON
dpc-4596	25	4	opinion	opinion	NOUN
dpc-4596	25	5	that	that	SCONJ
dpc-4596	25	6	agents	agent	NOUN
dpc-4596	25	7	that	that	PRON
dpc-4596	25	8	can	can	AUX
dpc-4596	25	9	effectively	effectively	ADV
dpc-4596	25	10	inhibit	inhibit	VERB
dpc-4596	25	11	both	both	DET
dpc-4596	25	12	mtor	mtor	NOUN
dpc-4596	25	13	complexes	complex	NOUN
dpc-4596	25	14	may	may	AUX
dpc-4596	25	15	be	be	AUX
dpc-4596	25	16	more	more	ADV
dpc-4596	25	17	effective	effective	ADJ
dpc-4596	25	18	in	in	ADP
dpc-4596	25	19	the	the	DET
dpc-4596	25	20	treatment	treatment	NOUN
dpc-4596	25	21	of	of	ADP
dpc-4596	25	22	psoriasis	psoriasis	NOUN
dpc-4596	25	23	.	.	PUNCT
dpc-4596	26	1	abstract	abstract	ADJ
dpc-4596	26	2	2	2	NUM
dpc-4596	26	3	original	original	ADJ
dpc-4596	26	4	article	article	NOUN
dpc-4596	26	5	|	|	ADV
dpc-4596	26	6	dermatol	dermatol	ADJ
dpc-4596	26	7	pract	pract	NOUN
dpc-4596	26	8	concept	concept	NOUN
dpc-4596	26	9	.	.	PUNCT
dpc-4596	27	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	27	2	introduction	introduction	NOUN
dpc-4596	27	3	psoriasis	psoriasis	NOUN
dpc-4596	27	4	is	be	AUX
dpc-4596	27	5	a	a	DET
dpc-4596	27	6	chronic	chronic	ADJ
dpc-4596	27	7	inflammatory	inflammatory	ADJ
dpc-4596	27	8	skin	skin	NOUN
dpc-4596	27	9	disease	disease	NOUN
dpc-4596	27	10	that	that	PRON
dpc-4596	27	11	is	be	AUX
dpc-4596	27	12	characterized	characterize	VERB
dpc-4596	27	13	by	by	ADP
dpc-4596	27	14	exacerbations	exacerbation	NOUN
dpc-4596	27	15	and	and	CCONJ
dpc-4596	27	16	remissions	remission	NOUN
dpc-4596	27	17	and	and	CCONJ
dpc-4596	27	18	that	that	PRON
dpc-4596	27	19	affects	affect	VERB
dpc-4596	27	20	2–3	2–3	NUM
dpc-4596	27	21	%	%	NOUN
dpc-4596	27	22	of	of	ADP
dpc-4596	27	23	the	the	DET
dpc-4596	27	24	population	population	NOUN
dpc-4596	28	1	[	[	X
dpc-4596	28	2	1	1	NUM
dpc-4596	28	3	]	]	PUNCT
dpc-4596	28	4	.	.	PUNCT
dpc-4596	29	1	the	the	DET
dpc-4596	29	2	etiology	etiology	NOUN
dpc-4596	29	3	of	of	ADP
dpc-4596	29	4	psoriasis	psoriasis	NOUN
dpc-4596	29	5	is	be	AUX
dpc-4596	29	6	founded	found	VERB
dpc-4596	29	7	upon	upon	SCONJ
dpc-4596	29	8	the	the	DET
dpc-4596	29	9	intricate	intricate	ADJ
dpc-4596	29	10	and	and	CCONJ
dpc-4596	29	11	evolving	evolve	VERB
dpc-4596	29	12	interplay	interplay	NOUN
dpc-4596	29	13	between	between	ADP
dpc-4596	29	14	genetic	genetic	ADJ
dpc-4596	29	15	and	and	CCONJ
dpc-4596	29	16	environmental	environmental	ADJ
dpc-4596	29	17	influences	influence	NOUN
dpc-4596	29	18	,	,	PUNCT
dpc-4596	29	19	along	along	ADP
dpc-4596	29	20	with	with	ADP
dpc-4596	29	21	the	the	DET
dpc-4596	29	22	activation	activation	NOUN
dpc-4596	29	23	of	of	ADP
dpc-4596	29	24	diverse	diverse	ADJ
dpc-4596	29	25	immune	immune	ADJ
dpc-4596	29	26	pathways	pathway	NOUN
dpc-4596	29	27	.	.	PUNCT
dpc-4596	30	1	in	in	ADP
dpc-4596	30	2	addition	addition	NOUN
dpc-4596	30	3	to	to	ADP
dpc-4596	30	4	the	the	DET
dpc-4596	30	5	innate	innate	ADJ
dpc-4596	30	6	and	and	CCONJ
dpc-4596	30	7	adaptive	adaptive	ADJ
dpc-4596	30	8	immune	immune	ADJ
dpc-4596	30	9	systems	system	NOUN
dpc-4596	30	10	,	,	PUNCT
dpc-4596	30	11	several	several	ADJ
dpc-4596	30	12	intracellular	intracellular	ADJ
dpc-4596	30	13	signaling	signal	VERB
dpc-4596	30	14	pathways	pathway	NOUN
dpc-4596	30	15	are	be	AUX
dpc-4596	30	16	involved	involve	VERB
dpc-4596	30	17	in	in	ADP
dpc-4596	30	18	the	the	DET
dpc-4596	30	19	pathogenesis	pathogenesis	NOUN
dpc-4596	30	20	[	[	X
dpc-4596	30	21	2	2	NUM
dpc-4596	30	22	]	]	PUNCT
dpc-4596	30	23	.	.	PUNCT
dpc-4596	31	1	among	among	ADP
dpc-4596	31	2	these	these	PRON
dpc-4596	31	3	,	,	PUNCT
dpc-4596	31	4	the	the	DET
dpc-4596	31	5	phosphoinositide-3	phosphoinositide-3	NUM
dpc-4596	31	6	kinase	kinase	NOUN
dpc-4596	31	7	/	/	SYM
dpc-4596	31	8	protein	protein	NOUN
dpc-4596	31	9	kinase	kinase	NOUN
dpc-4596	31	10	-	-	PUNCT
dpc-4596	31	11	b	b	NOUN
dpc-4596	31	12	/	/	SYM
dpc-4596	31	13	mammalian	mammalian	ADJ
dpc-4596	31	14	target	target	NOUN
dpc-4596	31	15	of	of	ADP
dpc-4596	31	16	rapamycin	rapamycin	NOUN
dpc-4596	31	17	(	(	PUNCT
dpc-4596	31	18	pi3k	pi3k	PROPN
dpc-4596	31	19	/	/	SYM
dpc-4596	31	20	akt	akt	PROPN
dpc-4596	31	21	/	/	SYM
dpc-4596	31	22	mtor	mtor	PROPN
dpc-4596	31	23	)	)	PUNCT
dpc-4596	31	24	pathway	pathway	NOUN
dpc-4596	31	25	has	have	AUX
dpc-4596	31	26	been	be	AUX
dpc-4596	31	27	described	describe	VERB
dpc-4596	31	28	as	as	ADP
dpc-4596	31	29	a	a	DET
dpc-4596	31	30	key	key	ADJ
dpc-4596	31	31	signaling	signaling	ADJ
dpc-4596	31	32	pathway	pathway	NOUN
dpc-4596	31	33	for	for	ADP
dpc-4596	31	34	cellular	cellular	ADJ
dpc-4596	31	35	metabolism	metabolism	NOUN
dpc-4596	31	36	and	and	CCONJ
dpc-4596	31	37	is	be	AUX
dpc-4596	31	38	currently	currently	ADV
dpc-4596	31	39	being	be	AUX
dpc-4596	31	40	investigated	investigate	VERB
dpc-4596	31	41	for	for	ADP
dpc-4596	31	42	its	its	PRON
dpc-4596	31	43	it	it	PRON
dpc-4596	31	44	is	be	AUX
dpc-4596	31	45	implicated	implicate	VERB
dpc-4596	31	46	in	in	ADP
dpc-4596	31	47	a	a	DET
dpc-4596	31	48	number	number	NOUN
dpc-4596	31	49	of	of	ADP
dpc-4596	31	50	diseases	disease	NOUN
dpc-4596	31	51	,	,	PUNCT
dpc-4596	31	52	including	include	VERB
dpc-4596	31	53	cancers	cancer	NOUN
dpc-4596	31	54	,	,	PUNCT
dpc-4596	31	55	metabolic	metabolic	NOUN
dpc-4596	31	56	disorders	disorder	NOUN
dpc-4596	31	57	,	,	PUNCT
dpc-4596	31	58	immune	immune	NOUN
dpc-4596	31	59	-	-	PUNCT
dpc-4596	31	60	mediated	mediate	VERB
dpc-4596	31	61	disorders	disorder	NOUN
dpc-4596	31	62	,	,	PUNCT
dpc-4596	31	63	and	and	CCONJ
dpc-4596	31	64	neurodegenerative	neurodegenerative	ADJ
dpc-4596	31	65	disorders	disorder	NOUN
dpc-4596	31	66	[	[	X
dpc-4596	31	67	3	3	NUM
dpc-4596	31	68	]	]	PUNCT
dpc-4596	31	69	.	.	PUNCT
dpc-4596	32	1	mtor	mtor	PROPN
dpc-4596	32	2	is	be	AUX
dpc-4596	32	3	a	a	DET
dpc-4596	32	4	serine	serine	NOUN
dpc-4596	32	5	/	/	SYM
dpc-4596	32	6	threonine	threonine	ADJ
dpc-4596	32	7	protein	protein	NOUN
dpc-4596	32	8	kinase	kinase	NOUN
dpc-4596	32	9	that	that	PRON
dpc-4596	32	10	forms	form	VERB
dpc-4596	32	11	the	the	DET
dpc-4596	32	12	catalytic	catalytic	ADJ
dpc-4596	32	13	subunit	subunit	NOUN
dpc-4596	32	14	of	of	ADP
dpc-4596	32	15	two	two	NUM
dpc-4596	32	16	multiprotein	multiprotein	ADJ
dpc-4596	32	17	complexes	complex	NOUN
dpc-4596	32	18	in	in	ADP
dpc-4596	32	19	eukaryotic	eukaryotic	ADJ
dpc-4596	32	20	cells	cell	NOUN
dpc-4596	32	21	,	,	PUNCT
dpc-4596	32	22	mtorc1	mtorc1	NOUN
dpc-4596	32	23	and	and	CCONJ
dpc-4596	32	24	mtorc2	mtorc2	PROPN
dpc-4596	32	25	.	.	PUNCT
dpc-4596	33	1	activation	activation	NOUN
dpc-4596	33	2	of	of	ADP
dpc-4596	33	3	the	the	DET
dpc-4596	33	4	mtor	mtor	NOUN
dpc-4596	33	5	signaling	signal	VERB
dpc-4596	33	6	pathway	pathway	NOUN
dpc-4596	33	7	results	result	NOUN
dpc-4596	33	8	in	in	ADP
dpc-4596	33	9	the	the	DET
dpc-4596	33	10	triggering	triggering	NOUN
dpc-4596	33	11	of	of	ADP
dpc-4596	33	12	anabolic	anabolic	NOUN
dpc-4596	33	13	processes	process	NOUN
dpc-4596	33	14	,	,	PUNCT
dpc-4596	33	15	which	which	PRON
dpc-4596	33	16	are	be	AUX
dpc-4596	33	17	required	require	VERB
dpc-4596	33	18	for	for	ADP
dpc-4596	33	19	cell	cell	NOUN
dpc-4596	33	20	growth	growth	NOUN
dpc-4596	33	21	and	and	CCONJ
dpc-4596	33	22	proliferation	proliferation	NOUN
dpc-4596	33	23	[	[	X
dpc-4596	33	24	4	4	NUM
dpc-4596	33	25	]	]	PUNCT
dpc-4596	33	26	.	.	PUNCT
dpc-4596	34	1	furthermore	furthermore	ADV
dpc-4596	34	2	,	,	PUNCT
dpc-4596	34	3	both	both	CCONJ
dpc-4596	34	4	the	the	DET
dpc-4596	34	5	mtorc1	mtorc1	NOUN
dpc-4596	34	6	and	and	CCONJ
dpc-4596	34	7	mtorc2	mtorc2	NOUN
dpc-4596	34	8	complexes	complex	NOUN
dpc-4596	34	9	play	play	VERB
dpc-4596	34	10	a	a	DET
dpc-4596	34	11	role	role	NOUN
dpc-4596	34	12	in	in	ADP
dpc-4596	34	13	regulating	regulate	VERB
dpc-4596	34	14	the	the	DET
dpc-4596	34	15	innate	innate	ADJ
dpc-4596	34	16	and	and	CCONJ
dpc-4596	34	17	adaptive	adaptive	ADJ
dpc-4596	34	18	immune	immune	ADJ
dpc-4596	34	19	system	system	NOUN
dpc-4596	34	20	.	.	PUNCT
dpc-4596	35	1	this	this	PRON
dpc-4596	35	2	is	be	AUX
dpc-4596	35	3	because	because	SCONJ
dpc-4596	35	4	immune	immune	ADJ
dpc-4596	35	5	cells	cell	NOUN
dpc-4596	35	6	respond	respond	VERB
dpc-4596	35	7	to	to	ADP
dpc-4596	35	8	pathogens	pathogen	NOUN
dpc-4596	35	9	and	and	CCONJ
dpc-4596	35	10	antigens	antigen	NOUN
dpc-4596	35	11	by	by	ADP
dpc-4596	35	12	reprogramming	reprogramme	VERB
dpc-4596	35	13	their	their	PRON
dpc-4596	35	14	metabolism	metabolism	NOUN
dpc-4596	35	15	,	,	PUNCT
dpc-4596	35	16	and	and	CCONJ
dpc-4596	35	17	maintaining	maintain	VERB
dpc-4596	35	18	this	this	DET
dpc-4596	35	19	homeostasis	homeostasis	NOUN
dpc-4596	35	20	is	be	AUX
dpc-4596	35	21	crucial	crucial	ADJ
dpc-4596	35	22	to	to	ADP
dpc-4596	35	23	preventing	prevent	VERB
dpc-4596	35	24	autoimmunity	autoimmunity	NOUN
dpc-4596	35	25	and	and	CCONJ
dpc-4596	35	26	malignancy	malignancy	NOUN
dpc-4596	35	27	[	[	X
dpc-4596	35	28	5	5	NUM
dpc-4596	35	29	]	]	PUNCT
dpc-4596	35	30	.	.	PUNCT
dpc-4596	36	1	mtor	mtor	PROPN
dpc-4596	36	2	pathway	pathway	PROPN
dpc-4596	36	3	plays	play	VERB
dpc-4596	36	4	a	a	DET
dpc-4596	36	5	pivotal	pivotal	ADJ
dpc-4596	36	6	role	role	NOUN
dpc-4596	36	7	in	in	ADP
dpc-4596	36	8	numerous	numerous	ADJ
dpc-4596	36	9	aspects	aspect	NOUN
dpc-4596	36	10	of	of	ADP
dpc-4596	36	11	epidermal	epidermal	ADJ
dpc-4596	36	12	homeostasis	homeostasis	NOUN
dpc-4596	36	13	,	,	PUNCT
dpc-4596	36	14	including	include	VERB
dpc-4596	36	15	skin	skin	NOUN
dpc-4596	36	16	morphogenesis	morphogenesis	NOUN
dpc-4596	36	17	during	during	ADP
dpc-4596	36	18	embryogenesis	embryogenesis	NOUN
dpc-4596	36	19	,	,	PUNCT
dpc-4596	36	20	the	the	DET
dpc-4596	36	21	formation	formation	NOUN
dpc-4596	36	22	of	of	ADP
dpc-4596	36	23	the	the	DET
dpc-4596	36	24	epidermal	epidermal	ADJ
dpc-4596	36	25	barrier	barrier	NOUN
dpc-4596	36	26	,	,	PUNCT
dpc-4596	36	27	hair	hair	NOUN
dpc-4596	36	28	growth	growth	NOUN
dpc-4596	36	29	,	,	PUNCT
dpc-4596	36	30	and	and	CCONJ
dpc-4596	36	31	skin	skin	NOUN
dpc-4596	36	32	repair	repair	NOUN
dpc-4596	36	33	.	.	PUNCT
dpc-4596	37	1	spatiotemporal	spatiotemporal	ADJ
dpc-4596	37	2	activation	activation	NOUN
dpc-4596	37	3	of	of	ADP
dpc-4596	37	4	the	the	DET
dpc-4596	37	5	pathway	pathway	NOUN
dpc-4596	37	6	in	in	ADP
dpc-4596	37	7	the	the	DET
dpc-4596	37	8	epidermal	epidermal	ADJ
dpc-4596	37	9	layers	layer	NOUN
dpc-4596	37	10	is	be	AUX
dpc-4596	37	11	essential	essential	ADJ
dpc-4596	37	12	for	for	ADP
dpc-4596	37	13	the	the	DET
dpc-4596	37	14	optimal	optimal	ADJ
dpc-4596	37	15	proliferation	proliferation	NOUN
dpc-4596	37	16	and	and	CCONJ
dpc-4596	37	17	differentiation	differentiation	NOUN
dpc-4596	37	18	of	of	ADP
dpc-4596	37	19	keratinocytes	keratinocyte	NOUN
dpc-4596	37	20	[	[	X
dpc-4596	37	21	6,7	6,7	NUM
dpc-4596	37	22	]	]	PUNCT
dpc-4596	37	23	.	.	PUNCT
dpc-4596	38	1	consequently	consequently	ADV
dpc-4596	38	2	,	,	PUNCT
dpc-4596	38	3	dysregulation	dysregulation	NOUN
dpc-4596	38	4	of	of	ADP
dpc-4596	38	5	the	the	DET
dpc-4596	38	6	mtor	mtor	PROPN
dpc-4596	38	7	pathway	pathway	NOUN
dpc-4596	38	8	is	be	AUX
dpc-4596	38	9	linked	link	VERB
dpc-4596	38	10	to	to	ADP
dpc-4596	38	11	the	the	DET
dpc-4596	38	12	development	development	NOUN
dpc-4596	38	13	of	of	ADP
dpc-4596	38	14	hyperproliferative	hyperproliferative	ADJ
dpc-4596	38	15	skin	skin	NOUN
dpc-4596	38	16	diseases	disease	NOUN
dpc-4596	38	17	,	,	PUNCT
dpc-4596	38	18	particularly	particularly	ADV
dpc-4596	38	19	skin	skin	NOUN
dpc-4596	38	20	cancers	cancer	NOUN
dpc-4596	38	21	and	and	CCONJ
dpc-4596	38	22	inflammatory	inflammatory	ADJ
dpc-4596	38	23	skin	skin	NOUN
dpc-4596	38	24	diseases	disease	NOUN
dpc-4596	38	25	[	[	X
dpc-4596	38	26	8	8	NUM
dpc-4596	38	27	]	]	PUNCT
dpc-4596	38	28	.	.	PUNCT
dpc-4596	39	1	a	a	DET
dpc-4596	39	2	number	number	NOUN
dpc-4596	39	3	of	of	ADP
dpc-4596	39	4	studies	study	NOUN
dpc-4596	39	5	have	have	AUX
dpc-4596	39	6	indicated	indicate	VERB
dpc-4596	39	7	the	the	DET
dpc-4596	39	8	potential	potential	ADJ
dpc-4596	39	9	benefits	benefit	NOUN
dpc-4596	39	10	of	of	ADP
dpc-4596	39	11	mtor	mtor	NOUN
dpc-4596	39	12	inhibitors	inhibitor	NOUN
dpc-4596	39	13	in	in	ADP
dpc-4596	39	14	the	the	DET
dpc-4596	39	15	treatment	treatment	NOUN
dpc-4596	39	16	of	of	ADP
dpc-4596	39	17	psoriasis	psoriasis	NOUN
dpc-4596	39	18	.	.	PUNCT
dpc-4596	40	1	consequently	consequently	ADV
dpc-4596	40	2	,	,	PUNCT
dpc-4596	40	3	the	the	DET
dpc-4596	40	4	role	role	NOUN
dpc-4596	40	5	of	of	ADP
dpc-4596	40	6	the	the	DET
dpc-4596	40	7	mtor	mtor	NOUN
dpc-4596	40	8	signaling	signal	VERB
dpc-4596	40	9	pathway	pathway	NOUN
dpc-4596	40	10	in	in	ADP
dpc-4596	40	11	the	the	DET
dpc-4596	40	12	pathogenesis	pathogenesis	NOUN
dpc-4596	40	13	of	of	ADP
dpc-4596	40	14	psoriasis	psoriasis	NOUN
dpc-4596	40	15	has	have	AUX
dpc-4596	40	16	become	become	VERB
dpc-4596	40	17	a	a	DET
dpc-4596	40	18	subject	subject	NOUN
dpc-4596	40	19	of	of	ADP
dpc-4596	40	20	interest	interest	NOUN
dpc-4596	40	21	.	.	PUNCT
dpc-4596	41	1	in	in	ADP
dpc-4596	41	2	a	a	DET
dpc-4596	41	3	study	study	NOUN
dpc-4596	41	4	conducted	conduct	VERB
dpc-4596	41	5	by	by	ADP
dpc-4596	41	6	buerger	buerger	NOUN
dpc-4596	41	7	et	et	PROPN
dpc-4596	41	8	al	al	PROPN
dpc-4596	41	9	.	.	PROPN
dpc-4596	41	10	,	,	PUNCT
dpc-4596	41	11	immunohistochemical	immunohistochemical	ADJ
dpc-4596	41	12	studies	study	NOUN
dpc-4596	41	13	were	be	AUX
dpc-4596	41	14	performed	perform	VERB
dpc-4596	41	15	on	on	ADP
dpc-4596	41	16	lesional	lesional	ADJ
dpc-4596	41	17	skin	skin	NOUN
dpc-4596	41	18	biopsy	biopsy	NOUN
dpc-4596	41	19	samples	sample	NOUN
dpc-4596	41	20	from	from	ADP
dpc-4596	41	21	patients	patient	NOUN
dpc-4596	41	22	with	with	ADP
dpc-4596	41	23	psoriasis	psoriasis	NOUN
dpc-4596	41	24	.	.	PUNCT
dpc-4596	42	1	these	these	DET
dpc-4596	42	2	studies	study	NOUN
dpc-4596	42	3	demonstrated	demonstrate	VERB
dpc-4596	42	4	that	that	SCONJ
dpc-4596	42	5	mtor	mtor	NOUN
dpc-4596	42	6	activation	activation	NOUN
dpc-4596	42	7	increased	increase	VERB
dpc-4596	42	8	in	in	ADP
dpc-4596	42	9	all	all	DET
dpc-4596	42	10	layers	layer	NOUN
dpc-4596	42	11	of	of	ADP
dpc-4596	42	12	the	the	DET
dpc-4596	42	13	epidermis	epidermis	NOUN
dpc-4596	43	1	[	[	X
dpc-4596	43	2	9	9	NUM
dpc-4596	43	3	]	]	PUNCT
dpc-4596	43	4	.	.	PUNCT
dpc-4596	44	1	furthermore	furthermore	ADV
dpc-4596	44	2	,	,	PUNCT
dpc-4596	44	3	staining	stain	VERB
dpc-4596	44	4	with	with	ADP
dpc-4596	44	5	phosphorylated	phosphorylate	VERB
dpc-4596	44	6	s6k	s6k	PROPN
dpc-4596	44	7	and	and	CCONJ
dpc-4596	44	8	4ebp1	4ebp1	NUM
dpc-4596	44	9	,	,	PUNCT
dpc-4596	44	10	which	which	PRON
dpc-4596	44	11	are	be	AUX
dpc-4596	44	12	downstream	downstream	ADJ
dpc-4596	44	13	signaling	signal	VERB
dpc-4596	44	14	proteins	protein	NOUN
dpc-4596	44	15	of	of	ADP
dpc-4596	44	16	the	the	DET
dpc-4596	44	17	pathway	pathway	NOUN
dpc-4596	44	18	,	,	PUNCT
dpc-4596	44	19	was	be	AUX
dpc-4596	44	20	increased	increase	VERB
dpc-4596	44	21	in	in	ADP
dpc-4596	44	22	the	the	DET
dpc-4596	44	23	suprabasal	suprabasal	NOUN
dpc-4596	44	24	layers	layer	NOUN
dpc-4596	44	25	.	.	PUNCT
dpc-4596	45	1	these	these	DET
dpc-4596	45	2	results	result	NOUN
dpc-4596	45	3	indicate	indicate	VERB
dpc-4596	45	4	that	that	SCONJ
dpc-4596	45	5	mtor	mtor	NOUN
dpc-4596	45	6	signaling	signal	VERB
dpc-4596	45	7	plays	play	VERB
dpc-4596	45	8	a	a	DET
dpc-4596	45	9	significant	significant	ADJ
dpc-4596	45	10	role	role	NOUN
dpc-4596	45	11	in	in	ADP
dpc-4596	45	12	the	the	DET
dpc-4596	45	13	development	development	NOUN
dpc-4596	45	14	of	of	ADP
dpc-4596	45	15	psoriatic	psoriatic	ADJ
dpc-4596	45	16	epidermal	epidermal	ADJ
dpc-4596	45	17	alterations	alteration	NOUN
dpc-4596	45	18	[	[	X
dpc-4596	45	19	9	9	NUM
dpc-4596	45	20	]	]	PUNCT
dpc-4596	45	21	.	.	PUNCT
dpc-4596	46	1	proinflammatory	proinflammatory	ADJ
dpc-4596	46	2	cytokines	cytokine	NOUN
dpc-4596	46	3	,	,	PUNCT
dpc-4596	46	4	in	in	ADP
dpc-4596	46	5	particular	particular	ADJ
dpc-4596	46	6	il-22	il-22	NOUN
dpc-4596	46	7	,	,	PUNCT
dpc-4596	46	8	il-17a	il-17a	PROPN
dpc-4596	46	9	,	,	PUNCT
dpc-4596	46	10	tnf	tnf	PROPN
dpc-4596	46	11	-	-	PUNCT
dpc-4596	46	12	alpha	alpha	NOUN
dpc-4596	46	13	,	,	PUNCT
dpc-4596	46	14	and	and	CCONJ
dpc-4596	46	15	il-1	il-1	ADP
dpc-4596	46	16	beta	beta	NOUN
dpc-4596	46	17	,	,	PUNCT
dpc-4596	46	18	have	have	AUX
dpc-4596	46	19	been	be	AUX
dpc-4596	46	20	demonstrated	demonstrate	VERB
dpc-4596	46	21	to	to	PART
dpc-4596	46	22	induce	induce	VERB
dpc-4596	46	23	heightened	heightened	ADJ
dpc-4596	46	24	activation	activation	NOUN
dpc-4596	46	25	of	of	ADP
dpc-4596	46	26	the	the	DET
dpc-4596	46	27	pi3k	pi3k	PROPN
dpc-4596	46	28	/	/	SYM
dpc-4596	46	29	akt	akt	PROPN
dpc-4596	46	30	/	/	SYM
dpc-4596	46	31	mtor	mtor	PROPN
dpc-4596	46	32	pathway	pathway	NOUN
dpc-4596	46	33	by	by	ADP
dpc-4596	46	34	interacting	interact	VERB
dpc-4596	46	35	with	with	ADP
dpc-4596	46	36	tyrosine	tyrosine	PROPN
dpc-4596	46	37	kinase	kinase	PROPN
dpc-4596	46	38	receptors	receptor	NOUN
dpc-4596	46	39	on	on	ADP
dpc-4596	46	40	the	the	DET
dpc-4596	46	41	cell	cell	NOUN
dpc-4596	46	42	membranes	membrane	NOUN
dpc-4596	46	43	of	of	ADP
dpc-4596	46	44	keratinocytes	keratinocyte	NOUN
dpc-4596	46	45	.	.	PUNCT
dpc-4596	47	1	overactivation	overactivation	NOUN
dpc-4596	47	2	of	of	ADP
dpc-4596	47	3	the	the	DET
dpc-4596	47	4	mtor	mtor	NOUN
dpc-4596	47	5	signaling	signal	VERB
dpc-4596	47	6	cascade	cascade	NOUN
dpc-4596	47	7	has	have	AUX
dpc-4596	47	8	been	be	AUX
dpc-4596	47	9	observed	observe	VERB
dpc-4596	47	10	to	to	PART
dpc-4596	47	11	result	result	VERB
dpc-4596	47	12	in	in	ADP
dpc-4596	47	13	hyperproliferation	hyperproliferation	NOUN
dpc-4596	47	14	,	,	PUNCT
dpc-4596	47	15	coupled	couple	VERB
dpc-4596	47	16	with	with	ADP
dpc-4596	47	17	the	the	DET
dpc-4596	47	18	inhibition	inhibition	NOUN
dpc-4596	47	19	of	of	ADP
dpc-4596	47	20	apoptosis	apoptosis	NOUN
dpc-4596	47	21	and	and	CCONJ
dpc-4596	47	22	differentiation	differentiation	NOUN
dpc-4596	47	23	in	in	ADP
dpc-4596	47	24	keratinocytes	keratinocyte	NOUN
dpc-4596	47	25	[	[	X
dpc-4596	47	26	10	10	NUM
dpc-4596	47	27	]	]	PUNCT
dpc-4596	47	28	.	.	PUNCT
dpc-4596	48	1	furthermore	furthermore	ADV
dpc-4596	48	2	,	,	PUNCT
dpc-4596	48	3	the	the	DET
dpc-4596	48	4	activation	activation	NOUN
dpc-4596	48	5	of	of	ADP
dpc-4596	48	6	the	the	DET
dpc-4596	48	7	pi3k	pi3k	PROPN
dpc-4596	48	8	/	/	SYM
dpc-4596	48	9	akt	akt	PROPN
dpc-4596	48	10	signaling	signal	VERB
dpc-4596	48	11	pathway	pathway	NOUN
dpc-4596	48	12	was	be	AUX
dpc-4596	48	13	observed	observe	VERB
dpc-4596	48	14	to	to	PART
dpc-4596	48	15	be	be	AUX
dpc-4596	48	16	elevated	elevate	VERB
dpc-4596	48	17	in	in	ADP
dpc-4596	48	18	peripheral	peripheral	ADJ
dpc-4596	48	19	blood	blood	NOUN
dpc-4596	48	20	mononuclear	mononuclear	ADJ
dpc-4596	48	21	cells	cell	NOUN
dpc-4596	48	22	of	of	ADP
dpc-4596	48	23	patients	patient	NOUN
dpc-4596	48	24	with	with	ADP
dpc-4596	48	25	psoriasis	psoriasis	NOUN
dpc-4596	48	26	in	in	ADP
dpc-4596	48	27	comparison	comparison	NOUN
dpc-4596	48	28	to	to	ADP
dpc-4596	48	29	healthy	healthy	ADJ
dpc-4596	48	30	individuals	individual	NOUN
dpc-4596	48	31	[	[	X
dpc-4596	48	32	11	11	NUM
dpc-4596	48	33	]	]	PUNCT
dpc-4596	48	34	.	.	PUNCT
dpc-4596	49	1	mtor	mtor	PROPN
dpc-4596	49	2	signaling	signal	VERB
dpc-4596	49	3	pathway	pathway	NOUN
dpc-4596	49	4	has	have	AUX
dpc-4596	49	5	been	be	AUX
dpc-4596	49	6	identified	identify	VERB
dpc-4596	49	7	as	as	ADP
dpc-4596	49	8	a	a	DET
dpc-4596	49	9	key	key	ADJ
dpc-4596	49	10	player	player	NOUN
dpc-4596	49	11	in	in	ADP
dpc-4596	49	12	the	the	DET
dpc-4596	49	13	pathogenesis	pathogenesis	NOUN
dpc-4596	49	14	of	of	ADP
dpc-4596	49	15	psoriasis	psoriasis	NOUN
dpc-4596	49	16	,	,	PUNCT
dpc-4596	49	17	with	with	ADP
dpc-4596	49	18	its	its	PRON
dpc-4596	49	19	dysregulation	dysregulation	NOUN
dpc-4596	49	20	leading	lead	VERB
dpc-4596	49	21	to	to	ADP
dpc-4596	49	22	the	the	DET
dpc-4596	49	23	secretion	secretion	NOUN
dpc-4596	49	24	of	of	ADP
dpc-4596	49	25	proinflammatory	proinflammatory	ADJ
dpc-4596	49	26	molecules	molecule	NOUN
dpc-4596	49	27	.	.	PUNCT
dpc-4596	50	1	in	in	ADP
dpc-4596	50	2	the	the	DET
dpc-4596	50	3	initial	initial	ADJ
dpc-4596	50	4	phase	phase	NOUN
dpc-4596	50	5	of	of	ADP
dpc-4596	50	6	psoriasis	psoriasis	NOUN
dpc-4596	50	7	,	,	PUNCT
dpc-4596	50	8	ll37	ll37	PROPN
dpc-4596	50	9	and	and	CCONJ
dpc-4596	50	10	self	self	NOUN
dpc-4596	50	11	-	-	PUNCT
dpc-4596	50	12	dna	dna	PROPN
dpc-4596	50	13	complex	complex	ADJ
dpc-4596	50	14	activate	activate	VERB
dpc-4596	50	15	plasmacytoid	plasmacytoid	NOUN
dpc-4596	50	16	dendritic	dendritic	ADJ
dpc-4596	50	17	cells	cell	NOUN
dpc-4596	50	18	to	to	PART
dpc-4596	50	19	produce	produce	VERB
dpc-4596	50	20	ifn	ifn	NOUN
dpc-4596	50	21	-	-	PUNCT
dpc-4596	50	22	alpha	alpha	NOUN
dpc-4596	50	23	via	via	ADP
dpc-4596	50	24	the	the	DET
dpc-4596	50	25	tlr-9	tlr-9	NUM
dpc-4596	50	26	receptor	receptor	NOUN
dpc-4596	50	27	.	.	PUNCT
dpc-4596	51	1	this	this	DET
dpc-4596	51	2	stimulation	stimulation	NOUN
dpc-4596	51	3	occurs	occur	VERB
dpc-4596	51	4	within	within	ADP
dpc-4596	51	5	the	the	DET
dpc-4596	51	6	cell	cell	NOUN
dpc-4596	51	7	through	through	ADP
dpc-4596	51	8	the	the	DET
dpc-4596	51	9	pi3k/	pi3k/	NOUN
dpc-4596	51	10	akt	akt	PROPN
dpc-4596	51	11	/	/	SYM
dpc-4596	51	12	mtor	mtor	PROPN
dpc-4596	51	13	pathway	pathway	NOUN
dpc-4596	52	1	[	[	X
dpc-4596	52	2	12	12	NUM
dpc-4596	52	3	]	]	PUNCT
dpc-4596	52	4	.	.	PUNCT
dpc-4596	53	1	previous	previous	ADJ
dpc-4596	53	2	immunohistochemical	immunohistochemical	ADJ
dpc-4596	53	3	examinations	examination	NOUN
dpc-4596	53	4	revealed	reveal	VERB
dpc-4596	53	5	that	that	SCONJ
dpc-4596	53	6	ccr7	ccr7	NOUN
dpc-4596	53	7	-	-	PUNCT
dpc-4596	53	8	expressing	express	VERB
dpc-4596	53	9	dendritic	dendritic	ADJ
dpc-4596	53	10	cells	cell	NOUN
dpc-4596	53	11	are	be	AUX
dpc-4596	53	12	present	present	ADJ
dpc-4596	53	13	in	in	ADP
dpc-4596	53	14	psoriatic	psoriatic	ADJ
dpc-4596	53	15	skin	skin	NOUN
dpc-4596	53	16	,	,	PUNCT
dpc-4596	53	17	but	but	CCONJ
dpc-4596	53	18	not	not	PART
dpc-4596	53	19	in	in	ADP
dpc-4596	53	20	healthy	healthy	ADJ
dpc-4596	53	21	skin	skin	NOUN
dpc-4596	53	22	.	.	PUNCT
dpc-4596	54	1	furthermore	furthermore	ADV
dpc-4596	54	2	,	,	PUNCT
dpc-4596	54	3	kuwabara	kuwabara	PROPN
dpc-4596	54	4	et	et	PROPN
dpc-4596	54	5	al	al	PROPN
dpc-4596	54	6	.	.	PROPN
dpc-4596	54	7	demonstrated	demonstrate	VERB
dpc-4596	54	8	that	that	SCONJ
dpc-4596	54	9	the	the	DET
dpc-4596	54	10	pi3k	pi3k	PROPN
dpc-4596	54	11	/	/	SYM
dpc-4596	54	12	akt	akt	PROPN
dpc-4596	54	13	pathway	pathway	NOUN
dpc-4596	54	14	plays	play	VERB
dpc-4596	54	15	a	a	DET
dpc-4596	54	16	pivotal	pivotal	ADJ
dpc-4596	54	17	role	role	NOUN
dpc-4596	54	18	in	in	ADP
dpc-4596	54	19	ccr7	ccr7	NOUN
dpc-4596	54	20	-	-	PUNCT
dpc-4596	54	21	related	relate	VERB
dpc-4596	54	22	il-23	il-23	NOUN
dpc-4596	54	23	production	production	NOUN
dpc-4596	54	24	from	from	ADP
dpc-4596	54	25	dendritic	dendritic	ADJ
dpc-4596	54	26	cells	cell	NOUN
dpc-4596	54	27	[	[	X
dpc-4596	54	28	13,14	13,14	NUM
dpc-4596	54	29	]	]	PUNCT
dpc-4596	54	30	.	.	PUNCT
dpc-4596	55	1	additionally	additionally	ADV
dpc-4596	55	2	,	,	PUNCT
dpc-4596	55	3	mtorc1	mtorc1	NOUN
dpc-4596	55	4	has	have	AUX
dpc-4596	55	5	been	be	AUX
dpc-4596	55	6	shown	show	VERB
dpc-4596	55	7	to	to	PART
dpc-4596	55	8	enhance	enhance	VERB
dpc-4596	55	9	the	the	DET
dpc-4596	55	10	proliferation	proliferation	NOUN
dpc-4596	55	11	and	and	CCONJ
dpc-4596	55	12	activation	activation	NOUN
dpc-4596	55	13	of	of	ADP
dpc-4596	55	14	th1	th1	PROPN
dpc-4596	55	15	and	and	CCONJ
dpc-4596	55	16	th17	th17	PROPN
dpc-4596	55	17	cells	cell	NOUN
dpc-4596	55	18	,	,	PUNCT
dpc-4596	55	19	thereby	thereby	ADV
dpc-4596	55	20	perpetuating	perpetuate	VERB
dpc-4596	55	21	a	a	DET
dpc-4596	55	22	vicious	vicious	ADJ
dpc-4596	55	23	cycle	cycle	NOUN
dpc-4596	55	24	of	of	ADP
dpc-4596	55	25	the	the	DET
dpc-4596	55	26	inflammatory	inflammatory	ADJ
dpc-4596	55	27	cascade	cascade	NOUN
dpc-4596	55	28	[	[	X
dpc-4596	55	29	15	15	NUM
dpc-4596	55	30	]	]	PUNCT
dpc-4596	55	31	.	.	PUNCT
dpc-4596	56	1	the	the	DET
dpc-4596	56	2	excessive	excessive	ADJ
dpc-4596	56	3	release	release	NOUN
dpc-4596	56	4	of	of	ADP
dpc-4596	56	5	cytokines	cytokine	NOUN
dpc-4596	56	6	,	,	PUNCT
dpc-4596	56	7	which	which	PRON
dpc-4596	56	8	play	play	VERB
dpc-4596	56	9	a	a	DET
dpc-4596	56	10	pivotal	pivotal	ADJ
dpc-4596	56	11	role	role	NOUN
dpc-4596	56	12	in	in	ADP
dpc-4596	56	13	the	the	DET
dpc-4596	56	14	maintenance	maintenance	NOUN
dpc-4596	56	15	phase	phase	NOUN
dpc-4596	56	16	of	of	ADP
dpc-4596	56	17	psoriasis	psoriasis	NOUN
dpc-4596	56	18	pathogenesis	pathogenesis	NOUN
dpc-4596	56	19	,	,	PUNCT
dpc-4596	56	20	is	be	AUX
dpc-4596	56	21	attributable	attributable	ADJ
dpc-4596	56	22	to	to	ADP
dpc-4596	56	23	th1	th1	PROPN
dpc-4596	56	24	,	,	PUNCT
dpc-4596	56	25	th17	th17	PROPN
dpc-4596	56	26	,	,	PUNCT
dpc-4596	56	27	and	and	CCONJ
dpc-4596	56	28	th22	th22	PROPN
dpc-4596	56	29	cells	cell	NOUN
dpc-4596	56	30	.	.	PUNCT
dpc-4596	57	1	mitra	mitra	PROPN
dpc-4596	57	2	et	et	PROPN
dpc-4596	57	3	al	al	PROPN
dpc-4596	57	4	.	.	PROPN
dpc-4596	57	5	demonstrated	demonstrate	VERB
dpc-4596	57	6	that	that	SCONJ
dpc-4596	57	7	il-22	il-22	ADV
dpc-4596	57	8	-	-	PUNCT
dpc-4596	57	9	induced	induce	VERB
dpc-4596	57	10	keratinocyte	keratinocyte	NOUN
dpc-4596	57	11	proliferation	proliferation	NOUN
dpc-4596	57	12	is	be	AUX
dpc-4596	57	13	dependent	dependent	ADJ
dpc-4596	57	14	on	on	ADP
dpc-4596	57	15	the	the	DET
dpc-4596	57	16	pi3k	pi3k	NOUN
dpc-4596	57	17	/	/	SYM
dpc-4596	57	18	akt/	akt/	PROPN
dpc-4596	57	19	mtor	mtor	PROPN
dpc-4596	57	20	pathway	pathway	NOUN
dpc-4596	58	1	[	[	X
dpc-4596	58	2	16	16	NUM
dpc-4596	58	3	]	]	PUNCT
dpc-4596	58	4	.	.	PUNCT
dpc-4596	59	1	another	another	DET
dpc-4596	59	2	potential	potential	ADJ
dpc-4596	59	3	mechanism	mechanism	NOUN
dpc-4596	59	4	by	by	ADP
dpc-4596	59	5	which	which	PRON
dpc-4596	59	6	hyperactive	hyperactive	ADJ
dpc-4596	59	7	pi3	pi3	NOUN
dpc-4596	59	8	-	-	PUNCT
dpc-4596	59	9	k	k	NOUN
dpc-4596	59	10	/	/	SYM
dpc-4596	59	11	akt	akt	PROPN
dpc-4596	59	12	/	/	PUNCT
dpc-4596	59	13	mtorc1	mtorc1	NOUN
dpc-4596	60	1	signaling	signal	VERB
dpc-4596	60	2	may	may	AUX
dpc-4596	60	3	contribute	contribute	VERB
dpc-4596	60	4	to	to	ADP
dpc-4596	60	5	the	the	DET
dpc-4596	60	6	pathogenesis	pathogenesis	NOUN
dpc-4596	60	7	of	of	ADP
dpc-4596	60	8	psoriasis	psoriasis	NOUN
dpc-4596	60	9	is	be	AUX
dpc-4596	60	10	through	through	ADP
dpc-4596	60	11	the	the	DET
dpc-4596	60	12	inhibition	inhibition	NOUN
dpc-4596	60	13	of	of	ADP
dpc-4596	60	14	autophagy	autophagy	NOUN
dpc-4596	60	15	.	.	PUNCT
dpc-4596	61	1	an	an	DET
dpc-4596	61	2	increase	increase	NOUN
dpc-4596	61	3	in	in	ADP
dpc-4596	61	4	mtorc1	mtorc1	NOUN
dpc-4596	61	5	activity	activity	NOUN
dpc-4596	61	6	impairs	impair	VERB
dpc-4596	61	7	nuclear	nuclear	ADJ
dpc-4596	61	8	degradation	degradation	NOUN
dpc-4596	61	9	and	and	CCONJ
dpc-4596	61	10	contributes	contribute	VERB
dpc-4596	61	11	to	to	ADP
dpc-4596	61	12	parakeratosis	parakeratosis	NOUN
dpc-4596	61	13	,	,	PUNCT
dpc-4596	61	14	a	a	DET
dpc-4596	61	15	defining	define	VERB
dpc-4596	61	16	feature	feature	NOUN
dpc-4596	61	17	of	of	ADP
dpc-4596	61	18	psoriasis	psoriasis	NOUN
dpc-4596	61	19	[	[	X
dpc-4596	61	20	10	10	NUM
dpc-4596	61	21	]	]	PUNCT
dpc-4596	61	22	.	.	PUNCT
dpc-4596	62	1	the	the	DET
dpc-4596	62	2	aforementioned	aforementioned	ADJ
dpc-4596	62	3	studies	study	NOUN
dpc-4596	62	4	indicate	indicate	VERB
dpc-4596	62	5	that	that	SCONJ
dpc-4596	62	6	the	the	DET
dpc-4596	62	7	activation	activation	NOUN
dpc-4596	62	8	of	of	ADP
dpc-4596	62	9	the	the	DET
dpc-4596	62	10	mtor	mtor	PROPN
dpc-4596	62	11	pathway	pathway	NOUN
dpc-4596	62	12	plays	play	VERB
dpc-4596	62	13	a	a	DET
dpc-4596	62	14	pivotal	pivotal	ADJ
dpc-4596	62	15	role	role	NOUN
dpc-4596	62	16	in	in	ADP
dpc-4596	62	17	the	the	DET
dpc-4596	62	18	development	development	NOUN
dpc-4596	62	19	of	of	ADP
dpc-4596	62	20	a	a	DET
dpc-4596	62	21	psoriatic	psoriatic	ADJ
dpc-4596	62	22	plaque	plaque	NOUN
dpc-4596	62	23	at	at	ADP
dpc-4596	62	24	all	all	DET
dpc-4596	62	25	stages	stage	NOUN
dpc-4596	62	26	of	of	ADP
dpc-4596	62	27	the	the	DET
dpc-4596	62	28	process	process	NOUN
dpc-4596	62	29	[	[	X
dpc-4596	62	30	17	17	NUM
dpc-4596	62	31	]	]	PUNCT
dpc-4596	62	32	.	.	PUNCT
dpc-4596	63	1	objectives	objective	NOUN
dpc-4596	63	2	given	give	VERB
dpc-4596	63	3	the	the	DET
dpc-4596	63	4	dearth	dearth	NOUN
dpc-4596	63	5	of	of	ADP
dpc-4596	63	6	data	datum	NOUN
dpc-4596	63	7	regarding	regard	VERB
dpc-4596	63	8	the	the	DET
dpc-4596	63	9	serum	serum	NOUN
dpc-4596	63	10	levels	level	NOUN
dpc-4596	63	11	of	of	ADP
dpc-4596	63	12	mtorc1	mtorc1	NOUN
dpc-4596	63	13	and	and	CCONJ
dpc-4596	63	14	mtorc2	mtorc2	PROPN
dpc-4596	63	15	,	,	PUNCT
dpc-4596	63	16	our	our	PRON
dpc-4596	63	17	objective	objective	NOUN
dpc-4596	63	18	was	be	AUX
dpc-4596	63	19	to	to	PART
dpc-4596	63	20	examine	examine	VERB
dpc-4596	63	21	the	the	DET
dpc-4596	63	22	levels	level	NOUN
dpc-4596	63	23	of	of	ADP
dpc-4596	63	24	these	these	DET
dpc-4596	63	25	complexes	complex	NOUN
dpc-4596	63	26	in	in	ADP
dpc-4596	63	27	the	the	DET
dpc-4596	63	28	serum	serum	NOUN
dpc-4596	63	29	of	of	ADP
dpc-4596	63	30	patients	patient	NOUN
dpc-4596	63	31	with	with	ADP
dpc-4596	63	32	plaque	plaque	NOUN
dpc-4596	63	33	psoriasis	psoriasis	NOUN
dpc-4596	63	34	and	and	CCONJ
dpc-4596	63	35	to	to	PART
dpc-4596	63	36	contrast	contrast	VERB
dpc-4596	63	37	these	these	DET
dpc-4596	63	38	findings	finding	NOUN
dpc-4596	63	39	with	with	ADP
dpc-4596	63	40	those	those	PRON
dpc-4596	63	41	of	of	ADP
dpc-4596	63	42	non	non	ADJ
dpc-4596	63	43	-	-	ADJ
dpc-4596	63	44	psoriatic	psoriatic	ADJ
dpc-4596	63	45	individuals	individual	NOUN
dpc-4596	63	46	.	.	PUNCT
dpc-4596	64	1	methods	method	NOUN
dpc-4596	64	2	participants	participant	NOUN
dpc-4596	64	3	and	and	CCONJ
dpc-4596	64	4	protocol	protocol	VERB
dpc-4596	64	5	the	the	DET
dpc-4596	64	6	prospective	prospective	ADJ
dpc-4596	64	7	case	case	NOUN
dpc-4596	64	8	-	-	PUNCT
dpc-4596	64	9	control	control	NOUN
dpc-4596	64	10	study	study	NOUN
dpc-4596	64	11	was	be	AUX
dpc-4596	64	12	designed	design	VERB
dpc-4596	64	13	to	to	PART
dpc-4596	64	14	include	include	VERB
dpc-4596	64	15	40	40	NUM
dpc-4596	64	16	patients	patient	NOUN
dpc-4596	64	17	with	with	ADP
dpc-4596	64	18	plaque	plaque	NOUN
dpc-4596	64	19	psoriasis	psoriasis	NOUN
dpc-4596	64	20	and	and	CCONJ
dpc-4596	64	21	40	40	NUM
dpc-4596	64	22	non	non	ADJ
dpc-4596	64	23	-	-	ADJ
dpc-4596	64	24	psoriatic	psoriatic	ADJ
dpc-4596	64	25	control	control	NOUN
dpc-4596	64	26	subjects	subject	NOUN
dpc-4596	64	27	.	.	PUNCT
dpc-4596	65	1	at	at	ADP
dpc-4596	65	2	the	the	DET
dpc-4596	65	3	initial	initial	ADJ
dpc-4596	65	4	visit	visit	NOUN
dpc-4596	65	5	,	,	PUNCT
dpc-4596	65	6	each	each	DET
dpc-4596	65	7	patient	patient	NOUN
dpc-4596	65	8	’s	’s	PART
dpc-4596	65	9	age	age	NOUN
dpc-4596	65	10	,	,	PUNCT
dpc-4596	65	11	sex	sex	NOUN
dpc-4596	65	12	,	,	PUNCT
dpc-4596	65	13	original	original	ADJ
dpc-4596	65	14	article	article	NOUN
dpc-4596	65	15	|	|	ADV
dpc-4596	65	16	dermatol	dermatol	ADJ
dpc-4596	65	17	pract	pract	NOUN
dpc-4596	65	18	concept	concept	NOUN
dpc-4596	65	19	.	.	PUNCT
dpc-4596	66	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	66	2	3	3	NUM
dpc-4596	66	3	disease	disease	NOUN
dpc-4596	66	4	duration	duration	NOUN
dpc-4596	66	5	,	,	PUNCT
dpc-4596	66	6	treatments	treatment	NOUN
dpc-4596	66	7	received	receive	VERB
dpc-4596	66	8	,	,	PUNCT
dpc-4596	66	9	and	and	CCONJ
dpc-4596	66	10	severity	severity	NOUN
dpc-4596	66	11	score	score	NOUN
dpc-4596	66	12	calculated	calculate	VERB
dpc-4596	66	13	by	by	ADP
dpc-4596	66	14	the	the	DET
dpc-4596	66	15	psoriasis	psoriasis	NOUN
dpc-4596	66	16	activity	activity	NOUN
dpc-4596	66	17	severity	severity	NOUN
dpc-4596	66	18	index	index	NOUN
dpc-4596	66	19	(	(	PUNCT
dpc-4596	66	20	pasi	pasi	NOUN
dpc-4596	66	21	)	)	PUNCT
dpc-4596	66	22	were	be	AUX
dpc-4596	66	23	recorded	record	VERB
dpc-4596	66	24	.	.	PUNCT
dpc-4596	67	1	routine	routine	ADJ
dpc-4596	67	2	biochemistry	biochemistry	NOUN
dpc-4596	67	3	tests	test	NOUN
dpc-4596	67	4	(	(	PUNCT
dpc-4596	67	5	ast	ast	INTJ
dpc-4596	67	6	,	,	PUNCT
dpc-4596	67	7	alt	alt	ADJ
dpc-4596	67	8	,	,	PUNCT
dpc-4596	67	9	cholesterol	cholesterol	NOUN
dpc-4596	67	10	,	,	PUNCT
dpc-4596	67	11	triglyceride	triglyceride	ADJ
dpc-4596	67	12	,	,	PUNCT
dpc-4596	67	13	hdl	hdl	PROPN
dpc-4596	67	14	,	,	PUNCT
dpc-4596	67	15	ldl	ldl	NOUN
dpc-4596	67	16	,	,	PUNCT
dpc-4596	67	17	urea	urea	NOUN
dpc-4596	67	18	,	,	PUNCT
dpc-4596	67	19	creatinine	creatinine	NOUN
dpc-4596	67	20	)	)	PUNCT
dpc-4596	67	21	,	,	PUNCT
dpc-4596	67	22	complete	complete	ADJ
dpc-4596	67	23	blood	blood	NOUN
dpc-4596	67	24	count	count	NOUN
dpc-4596	67	25	,	,	PUNCT
dpc-4596	67	26	sedimentation	sedimentation	NOUN
dpc-4596	67	27	rate	rate	NOUN
dpc-4596	67	28	,	,	PUNCT
dpc-4596	67	29	and	and	CCONJ
dpc-4596	67	30	crp	crp	PROPN
dpc-4596	67	31	values	value	NOUN
dpc-4596	67	32	were	be	AUX
dpc-4596	67	33	also	also	ADV
dpc-4596	67	34	examined	examine	VERB
dpc-4596	67	35	.	.	PUNCT
dpc-4596	68	1	in	in	ADP
dpc-4596	68	2	patients	patient	NOUN
dpc-4596	68	3	with	with	ADP
dpc-4596	68	4	plaque	plaque	NOUN
dpc-4596	68	5	psoriasis	psoriasis	NOUN
dpc-4596	68	6	,	,	PUNCT
dpc-4596	68	7	those	those	PRON
dpc-4596	68	8	with	with	ADP
dpc-4596	68	9	a	a	DET
dpc-4596	68	10	pasi	pasi	NOUN
dpc-4596	68	11	score	score	NOUN
dpc-4596	68	12	of	of	ADP
dpc-4596	68	13	≤10	≤10	PROPN
dpc-4596	68	14	were	be	AUX
dpc-4596	68	15	grouped	group	VERB
dpc-4596	68	16	as	as	ADP
dpc-4596	68	17	having	have	VERB
dpc-4596	68	18	mild	mild	ADJ
dpc-4596	68	19	plaque	plaque	NOUN
dpc-4596	68	20	psoriasis	psoriasis	NOUN
dpc-4596	68	21	,	,	PUNCT
dpc-4596	68	22	while	while	SCONJ
dpc-4596	68	23	those	those	PRON
dpc-4596	68	24	with	with	ADP
dpc-4596	68	25	a	a	DET
dpc-4596	68	26	pasi	pasi	NOUN
dpc-4596	68	27	score	score	NOUN
dpc-4596	68	28	of	of	ADP
dpc-4596	68	29	>	>	X
dpc-4596	68	30	10	10	NUM
dpc-4596	68	31	were	be	AUX
dpc-4596	68	32	grouped	group	VERB
dpc-4596	68	33	as	as	ADP
dpc-4596	68	34	having	having	AUX
dpc-4596	68	35	moderate	moderate	ADJ
dpc-4596	68	36	to	to	ADP
dpc-4596	68	37	severe	severe	ADJ
dpc-4596	68	38	plaque	plaque	NOUN
dpc-4596	68	39	psoriasis	psoriasis	NOUN
dpc-4596	68	40	.	.	PUNCT
dpc-4596	69	1	once	once	ADV
dpc-4596	69	2	the	the	DET
dpc-4596	69	3	patient	patient	ADJ
dpc-4596	69	4	cohort	cohort	NOUN
dpc-4596	69	5	had	have	AUX
dpc-4596	69	6	been	be	AUX
dpc-4596	69	7	completed	complete	VERB
dpc-4596	69	8	,	,	PUNCT
dpc-4596	69	9	non	non	ADJ
dpc-4596	69	10	-	-	ADJ
dpc-4596	69	11	psoriatic	psoriatic	ADJ
dpc-4596	69	12	volunteers	volunteer	NOUN
dpc-4596	69	13	who	who	PRON
dpc-4596	69	14	were	be	AUX
dpc-4596	69	15	comparable	comparable	ADJ
dpc-4596	69	16	in	in	ADP
dpc-4596	69	17	terms	term	NOUN
dpc-4596	69	18	of	of	ADP
dpc-4596	69	19	age	age	NOUN
dpc-4596	69	20	and	and	CCONJ
dpc-4596	69	21	sex	sex	NOUN
dpc-4596	69	22	were	be	AUX
dpc-4596	69	23	included	include	VERB
dpc-4596	69	24	in	in	ADP
dpc-4596	69	25	the	the	DET
dpc-4596	69	26	study	study	NOUN
dpc-4596	69	27	.	.	PUNCT
dpc-4596	70	1	the	the	DET
dpc-4596	70	2	following	follow	VERB
dpc-4596	70	3	exclusion	exclusion	NOUN
dpc-4596	70	4	criteria	criterion	NOUN
dpc-4596	70	5	were	be	AUX
dpc-4596	70	6	accepted	accept	VERB
dpc-4596	70	7	for	for	ADP
dpc-4596	70	8	the	the	DET
dpc-4596	70	9	patient	patient	NOUN
dpc-4596	70	10	group	group	NOUN
dpc-4596	70	11	:	:	PUNCT
dpc-4596	70	12	the	the	DET
dpc-4596	70	13	use	use	NOUN
dpc-4596	70	14	of	of	ADP
dpc-4596	70	15	topical	topical	ADJ
dpc-4596	70	16	treatments	treatment	NOUN
dpc-4596	70	17	(	(	PUNCT
dpc-4596	70	18	corticosteroid	corticosteroid	ADJ
dpc-4596	70	19	,	,	PUNCT
dpc-4596	70	20	vitamin	vitamin	NOUN
dpc-4596	70	21	d3	d3	PROPN
dpc-4596	70	22	analogue	analogue	NOUN
dpc-4596	70	23	,	,	PUNCT
dpc-4596	70	24	retinoid	retinoid	NOUN
dpc-4596	70	25	)	)	PUNCT
dpc-4596	70	26	within	within	ADP
dpc-4596	70	27	the	the	DET
dpc-4596	70	28	previous	previous	ADJ
dpc-4596	70	29	two	two	NUM
dpc-4596	70	30	months	month	NOUN
dpc-4596	70	31	,	,	PUNCT
dpc-4596	70	32	and	and	CCONJ
dpc-4596	70	33	systemic	systemic	ADJ
dpc-4596	70	34	treatments	treatment	NOUN
dpc-4596	70	35	(	(	PUNCT
dpc-4596	70	36	corticosteroid	corticosteroid	ADJ
dpc-4596	70	37	,	,	PUNCT
dpc-4596	70	38	retinoid	retinoid	NOUN
dpc-4596	70	39	,	,	PUNCT
dpc-4596	70	40	phototherapy	phototherapy	NOUN
dpc-4596	70	41	,	,	PUNCT
dpc-4596	70	42	immunosuppressive	immunosuppressive	ADJ
dpc-4596	70	43	and	and	CCONJ
dpc-4596	70	44	biological	biological	ADJ
dpc-4596	70	45	agent	agent	NOUN
dpc-4596	70	46	)	)	PUNCT
dpc-4596	70	47	within	within	ADP
dpc-4596	70	48	the	the	DET
dpc-4596	70	49	previous	previous	ADJ
dpc-4596	70	50	six	six	NUM
dpc-4596	70	51	months	month	NOUN
dpc-4596	70	52	.	.	PUNCT
dpc-4596	71	1	additionally	additionally	ADV
dpc-4596	71	2	,	,	PUNCT
dpc-4596	71	3	pregnant	pregnant	ADJ
dpc-4596	71	4	and	and	CCONJ
dpc-4596	71	5	breastfeeding	breastfeed	VERB
dpc-4596	71	6	women	woman	NOUN
dpc-4596	71	7	were	be	AUX
dpc-4596	71	8	not	not	PART
dpc-4596	71	9	included	include	VERB
dpc-4596	71	10	in	in	ADP
dpc-4596	71	11	the	the	DET
dpc-4596	71	12	study	study	NOUN
dpc-4596	71	13	.	.	PUNCT
dpc-4596	72	1	patients	patient	NOUN
dpc-4596	72	2	with	with	ADP
dpc-4596	72	3	a	a	DET
dpc-4596	72	4	history	history	NOUN
dpc-4596	72	5	of	of	ADP
dpc-4596	72	6	eating	eat	VERB
dpc-4596	72	7	disorders	disorder	NOUN
dpc-4596	72	8	(	(	PUNCT
dpc-4596	72	9	anorexia	anorexia	NOUN
dpc-4596	72	10	and	and	CCONJ
dpc-4596	72	11	obesity	obesity	NOUN
dpc-4596	72	12	)	)	PUNCT
dpc-4596	72	13	as	as	ADV
dpc-4596	72	14	well	well	ADV
dpc-4596	72	15	as	as	ADP
dpc-4596	72	16	those	those	PRON
dpc-4596	72	17	with	with	ADP
dpc-4596	72	18	a	a	DET
dpc-4596	72	19	history	history	NOUN
dpc-4596	72	20	of	of	ADP
dpc-4596	72	21	any	any	DET
dpc-4596	72	22	systemic	systemic	ADJ
dpc-4596	72	23	disease	disease	NOUN
dpc-4596	72	24	(	(	PUNCT
dpc-4596	72	25	including	include	VERB
dpc-4596	72	26	acute	acute	ADJ
dpc-4596	72	27	or	or	CCONJ
dpc-4596	72	28	chronic	chronic	ADJ
dpc-4596	72	29	infection	infection	NOUN
dpc-4596	72	30	,	,	PUNCT
dpc-4596	72	31	diabetes	diabetes	NOUN
dpc-4596	72	32	mellitus	mellitus	NOUN
dpc-4596	72	33	,	,	PUNCT
dpc-4596	72	34	thyroid	thyroid	NOUN
dpc-4596	72	35	disorders	disorder	NOUN
dpc-4596	72	36	,	,	PUNCT
dpc-4596	72	37	chronic	chronic	ADJ
dpc-4596	72	38	renal	renal	ADJ
dpc-4596	72	39	or	or	CCONJ
dpc-4596	72	40	liver	liver	NOUN
dpc-4596	72	41	disease	disease	NOUN
dpc-4596	72	42	,	,	PUNCT
dpc-4596	72	43	any	any	DET
dpc-4596	72	44	malignancy	malignancy	NOUN
dpc-4596	72	45	,	,	PUNCT
dpc-4596	72	46	polycystic	polycystic	ADJ
dpc-4596	72	47	ovarian	ovarian	ADJ
dpc-4596	72	48	syndrome	syndrome	NOUN
dpc-4596	72	49	,	,	PUNCT
dpc-4596	72	50	or	or	CCONJ
dpc-4596	72	51	any	any	DET
dpc-4596	72	52	endocrinologic	endocrinologic	ADJ
dpc-4596	72	53	disorders	disorder	NOUN
dpc-4596	72	54	or	or	CCONJ
dpc-4596	72	55	autoimmune	autoimmune	ADJ
dpc-4596	72	56	diseases	disease	NOUN
dpc-4596	72	57	)	)	PUNCT
dpc-4596	72	58	were	be	AUX
dpc-4596	72	59	excluded	exclude	VERB
dpc-4596	72	60	from	from	ADP
dpc-4596	72	61	the	the	DET
dpc-4596	72	62	study	study	NOUN
dpc-4596	72	63	.	.	PUNCT
dpc-4596	73	1	individuals	individual	NOUN
dpc-4596	73	2	with	with	ADP
dpc-4596	73	3	a	a	DET
dpc-4596	73	4	history	history	NOUN
dpc-4596	73	5	of	of	ADP
dpc-4596	73	6	any	any	DET
dpc-4596	73	7	systemic	systemic	ADJ
dpc-4596	73	8	disease	disease	NOUN
dpc-4596	73	9	,	,	PUNCT
dpc-4596	73	10	recent	recent	ADJ
dpc-4596	73	11	systemic	systemic	ADJ
dpc-4596	73	12	treatment	treatment	NOUN
dpc-4596	73	13	(	(	PUNCT
dpc-4596	73	14	within	within	ADP
dpc-4596	73	15	the	the	DET
dpc-4596	73	16	previous	previous	ADJ
dpc-4596	73	17	six	six	NUM
dpc-4596	73	18	months	month	NOUN
dpc-4596	73	19	)	)	PUNCT
dpc-4596	73	20	,	,	PUNCT
dpc-4596	73	21	or	or	CCONJ
dpc-4596	73	22	recent	recent	ADJ
dpc-4596	73	23	topical	topical	ADJ
dpc-4596	73	24	treatment	treatment	NOUN
dpc-4596	73	25	(	(	PUNCT
dpc-4596	73	26	within	within	ADP
dpc-4596	73	27	the	the	DET
dpc-4596	73	28	previous	previous	ADJ
dpc-4596	73	29	two	two	NUM
dpc-4596	73	30	months	month	NOUN
dpc-4596	73	31	)	)	PUNCT
dpc-4596	73	32	were	be	AUX
dpc-4596	73	33	excluded	exclude	VERB
dpc-4596	73	34	from	from	ADP
dpc-4596	73	35	the	the	DET
dpc-4596	73	36	control	control	NOUN
dpc-4596	73	37	group	group	NOUN
dpc-4596	73	38	.	.	PUNCT
dpc-4596	74	1	the	the	DET
dpc-4596	74	2	study	study	NOUN
dpc-4596	74	3	population	population	NOUN
dpc-4596	74	4	comprised	comprise	VERB
dpc-4596	74	5	individuals	individual	NOUN
dpc-4596	74	6	aged	age	VERB
dpc-4596	74	7	18	18	NUM
dpc-4596	74	8	years	year	NOUN
dpc-4596	74	9	or	or	CCONJ
dpc-4596	74	10	older	old	ADJ
dpc-4596	74	11	with	with	ADP
dpc-4596	74	12	a	a	DET
dpc-4596	74	13	normal	normal	ADJ
dpc-4596	74	14	body	body	NOUN
dpc-4596	74	15	mass	mass	NOUN
dpc-4596	74	16	index	index	NOUN
dpc-4596	74	17	(	(	PUNCT
dpc-4596	74	18	bmi	bmi	PROPN
dpc-4596	74	19	)	)	PUNCT
dpc-4596	74	20	(	(	PUNCT
dpc-4596	74	21	18.5	18.5	NUM
dpc-4596	74	22	-	-	SYM
dpc-4596	74	23	25	25	NUM
dpc-4596	74	24	kg	kg	NOUN
dpc-4596	74	25	/	/	SYM
dpc-4596	74	26	m²	m²	PROPN
dpc-4596	74	27	)	)	PUNCT
dpc-4596	74	28	.	.	PUNCT
dpc-4596	75	1	prior	prior	ADV
dpc-4596	75	2	to	to	ADP
dpc-4596	75	3	their	their	PRON
dpc-4596	75	4	participation	participation	NOUN
dpc-4596	75	5	in	in	ADP
dpc-4596	75	6	the	the	DET
dpc-4596	75	7	study	study	NOUN
dpc-4596	75	8	,	,	PUNCT
dpc-4596	75	9	all	all	DET
dpc-4596	75	10	participants	participant	NOUN
dpc-4596	75	11	were	be	AUX
dpc-4596	75	12	provided	provide	VERB
dpc-4596	75	13	with	with	ADP
dpc-4596	75	14	a	a	DET
dpc-4596	75	15	comprehensive	comprehensive	ADJ
dpc-4596	75	16	explanation	explanation	NOUN
dpc-4596	75	17	of	of	ADP
dpc-4596	75	18	the	the	DET
dpc-4596	75	19	study	study	NOUN
dpc-4596	75	20	’s	’s	PART
dpc-4596	75	21	purpose	purpose	NOUN
dpc-4596	75	22	,	,	PUNCT
dpc-4596	75	23	nature	nature	NOUN
dpc-4596	75	24	,	,	PUNCT
dpc-4596	75	25	and	and	CCONJ
dpc-4596	75	26	related	related	ADJ
dpc-4596	75	27	procedures	procedure	NOUN
dpc-4596	75	28	.	.	PUNCT
dpc-4596	76	1	this	this	DET
dpc-4596	76	2	information	information	NOUN
dpc-4596	76	3	was	be	AUX
dpc-4596	76	4	presented	present	VERB
dpc-4596	76	5	in	in	ADP
dpc-4596	76	6	a	a	DET
dpc-4596	76	7	clear	clear	ADJ
dpc-4596	76	8	and	and	CCONJ
dpc-4596	76	9	concise	concise	ADJ
dpc-4596	76	10	manner	manner	NOUN
dpc-4596	76	11	,	,	PUNCT
dpc-4596	76	12	ensuring	ensure	VERB
dpc-4596	76	13	that	that	SCONJ
dpc-4596	76	14	all	all	DET
dpc-4596	76	15	participants	participant	NOUN
dpc-4596	76	16	had	have	VERB
dpc-4596	76	17	a	a	DET
dpc-4596	76	18	full	full	ADJ
dpc-4596	76	19	understanding	understanding	NOUN
dpc-4596	76	20	of	of	ADP
dpc-4596	76	21	the	the	DET
dpc-4596	76	22	study	study	NOUN
dpc-4596	76	23	and	and	CCONJ
dpc-4596	76	24	their	their	PRON
dpc-4596	76	25	role	role	NOUN
dpc-4596	76	26	in	in	ADP
dpc-4596	76	27	it	it	PRON
dpc-4596	76	28	.	.	PUNCT
dpc-4596	77	1	the	the	DET
dpc-4596	77	2	study	study	NOUN
dpc-4596	77	3	was	be	AUX
dpc-4596	77	4	approved	approve	VERB
dpc-4596	77	5	by	by	ADP
dpc-4596	77	6	the	the	DET
dpc-4596	77	7	local	local	ADJ
dpc-4596	77	8	ethics	ethic	NOUN
dpc-4596	77	9	committee	committee	PROPN
dpc-4596	77	10	(	(	PUNCT
dpc-4596	77	11	approval	approval	NOUN
dpc-4596	77	12	number	number	NOUN
dpc-4596	77	13	:	:	PUNCT
dpc-4596	77	14	3454	3454	NUM
dpc-4596	77	15	)	)	PUNCT
dpc-4596	77	16	.	.	PUNCT
dpc-4596	78	1	serum	serum	NOUN
dpc-4596	78	2	mtorc1	mtorc1	NOUN
dpc-4596	78	3	and	and	CCONJ
dpc-4596	78	4	mtorc2	mtorc2	NOUN
dpc-4596	78	5	analysis	analysis	NOUN
dpc-4596	78	6	venous	venous	ADJ
dpc-4596	78	7	blood	blood	NOUN
dpc-4596	78	8	samples	sample	NOUN
dpc-4596	78	9	were	be	AUX
dpc-4596	78	10	collected	collect	VERB
dpc-4596	78	11	from	from	ADP
dpc-4596	78	12	participants	participant	NOUN
dpc-4596	78	13	to	to	PART
dpc-4596	78	14	evaluate	evaluate	VERB
dpc-4596	78	15	serum	serum	NOUN
dpc-4596	78	16	mtorc1	mtorc1	NOUN
dpc-4596	78	17	and	and	CCONJ
dpc-4596	78	18	mtorc2	mtorc2	PROPN
dpc-4596	78	19	levels	level	NOUN
dpc-4596	78	20	.	.	PUNCT
dpc-4596	79	1	the	the	DET
dpc-4596	79	2	samples	sample	NOUN
dpc-4596	79	3	were	be	AUX
dpc-4596	79	4	then	then	ADV
dpc-4596	79	5	centrifuged	centrifuge	VERB
dpc-4596	79	6	at	at	ADP
dpc-4596	79	7	3000	3000	NUM
dpc-4596	79	8	rpm	rpm	NOUN
dpc-4596	79	9	for	for	ADP
dpc-4596	79	10	20	20	NUM
dpc-4596	79	11	minutes	minute	NOUN
dpc-4596	79	12	,	,	PUNCT
dpc-4596	79	13	and	and	CCONJ
dpc-4596	79	14	the	the	DET
dpc-4596	79	15	supernatant	supernatant	NOUN
dpc-4596	79	16	of	of	ADP
dpc-4596	79	17	the	the	DET
dpc-4596	79	18	serum	serum	NOUN
dpc-4596	79	19	was	be	AUX
dpc-4596	79	20	collected	collect	VERB
dpc-4596	79	21	and	and	CCONJ
dpc-4596	79	22	placed	place	VERB
dpc-4596	79	23	in	in	ADP
dpc-4596	79	24	appropriate	appropriate	ADJ
dpc-4596	79	25	tubes	tube	NOUN
dpc-4596	79	26	.	.	PUNCT
dpc-4596	80	1	these	these	PRON
dpc-4596	80	2	were	be	AUX
dpc-4596	80	3	stored	store	VERB
dpc-4596	80	4	in	in	ADP
dpc-4596	80	5	a	a	DET
dpc-4596	80	6	-80	-80	NOUN
dpc-4596	80	7	degree	degree	NOUN
dpc-4596	80	8	cooler	cooler	NOUN
dpc-4596	80	9	until	until	ADP
dpc-4596	80	10	the	the	DET
dpc-4596	80	11	day	day	NOUN
dpc-4596	80	12	of	of	ADP
dpc-4596	80	13	the	the	DET
dpc-4596	80	14	study	study	NOUN
dpc-4596	80	15	.	.	PUNCT
dpc-4596	81	1	the	the	DET
dpc-4596	81	2	analysis	analysis	NOUN
dpc-4596	81	3	was	be	AUX
dpc-4596	81	4	conducted	conduct	VERB
dpc-4596	81	5	using	use	VERB
dpc-4596	81	6	a	a	DET
dpc-4596	81	7	commercially	commercially	ADV
dpc-4596	81	8	available	available	ADJ
dpc-4596	81	9	bt	bt	NOUN
dpc-4596	81	10	lab	lab	PROPN
dpc-4596	81	11	human	human	PROPN
dpc-4596	81	12	mtor	mtor	PROPN
dpc-4596	81	13	complex	complex	ADJ
dpc-4596	81	14	1	1	NUM
dpc-4596	81	15	elisa	elisa	NOUN
dpc-4596	81	16	kit	kit	NOUN
dpc-4596	81	17	(	(	PUNCT
dpc-4596	81	18	catalog	catalog	NOUN
dpc-4596	81	19	no	no	NOUN
dpc-4596	81	20	:	:	PUNCT
dpc-4596	81	21	e4750hu	e4750hu	NUM
dpc-4596	81	22	)	)	PUNCT
dpc-4596	81	23	and	and	CCONJ
dpc-4596	81	24	human	human	ADJ
dpc-4596	81	25	mtor	mtor	NOUN
dpc-4596	81	26	complex	complex	ADJ
dpc-4596	81	27	2	2	NUM
dpc-4596	81	28	elisa	elisa	NOUN
dpc-4596	81	29	kit	kit	NOUN
dpc-4596	81	30	(	(	PUNCT
dpc-4596	81	31	catalog	catalog	NOUN
dpc-4596	81	32	no	no	NOUN
dpc-4596	81	33	:	:	PUNCT
dpc-4596	81	34	e4751hu	e4751hu	PROPN
dpc-4596	81	35	)	)	PUNCT
dpc-4596	81	36	.	.	PUNCT
dpc-4596	82	1	in	in	ADP
dpc-4596	82	2	both	both	DET
dpc-4596	82	3	evaluations	evaluation	NOUN
dpc-4596	82	4	,	,	PUNCT
dpc-4596	82	5	the	the	DET
dpc-4596	82	6	results	result	NOUN
dpc-4596	82	7	were	be	AUX
dpc-4596	82	8	quantified	quantify	VERB
dpc-4596	82	9	spectrophotometrically	spectrophotometrically	ADV
dpc-4596	82	10	at	at	ADP
dpc-4596	82	11	450	450	NUM
dpc-4596	82	12	nm	nm	NOUN
dpc-4596	82	13	through	through	ADP
dpc-4596	82	14	the	the	DET
dpc-4596	82	15	utilization	utilization	NOUN
dpc-4596	82	16	of	of	ADP
dpc-4596	82	17	the	the	DET
dpc-4596	82	18	sandwich	sandwich	NOUN
dpc-4596	82	19	elisa	elisa	NOUN
dpc-4596	82	20	method	method	NOUN
dpc-4596	82	21	.	.	PUNCT
dpc-4596	83	1	the	the	DET
dpc-4596	83	2	standard	standard	ADJ
dpc-4596	83	3	curve	curve	NOUN
dpc-4596	83	4	range	range	NOUN
dpc-4596	83	5	for	for	ADP
dpc-4596	83	6	the	the	DET
dpc-4596	83	7	mtorc1	mtorc1	NOUN
dpc-4596	83	8	kit	kit	NOUN
dpc-4596	83	9	was	be	AUX
dpc-4596	83	10	10	10	NUM
dpc-4596	83	11	-	-	SYM
dpc-4596	83	12	1500	1500	NUM
dpc-4596	83	13	ng	ng	PROPN
dpc-4596	83	14	/	/	SYM
dpc-4596	83	15	l	l	PROPN
dpc-4596	83	16	,	,	PUNCT
dpc-4596	83	17	with	with	ADP
dpc-4596	83	18	a	a	DET
dpc-4596	83	19	sensitivity	sensitivity	NOUN
dpc-4596	83	20	of	of	ADP
dpc-4596	83	21	4.95	4.95	NUM
dpc-4596	83	22	ng	ng	PROPN
dpc-4596	83	23	/	/	SYM
dpc-4596	83	24	l	l	PROPN
dpc-4596	83	25	,	,	PUNCT
dpc-4596	83	26	while	while	SCONJ
dpc-4596	83	27	the	the	DET
dpc-4596	83	28	standard	standard	ADJ
dpc-4596	83	29	curve	curve	NOUN
dpc-4596	83	30	range	range	NOUN
dpc-4596	83	31	for	for	ADP
dpc-4596	83	32	the	the	DET
dpc-4596	83	33	mtorc2	mtorc2	PROPN
dpc-4596	83	34	kit	kit	NOUN
dpc-4596	83	35	was	be	AUX
dpc-4596	83	36	5	5	NUM
dpc-4596	83	37	-	-	SYM
dpc-4596	83	38	1000	1000	NUM
dpc-4596	83	39	ng	ng	PROPN
dpc-4596	83	40	/	/	SYM
dpc-4596	83	41	l	l	PROPN
dpc-4596	83	42	,	,	PUNCT
dpc-4596	83	43	with	with	ADP
dpc-4596	83	44	a	a	DET
dpc-4596	83	45	sensitivity	sensitivity	NOUN
dpc-4596	83	46	of	of	ADP
dpc-4596	83	47	2.61	2.61	NUM
dpc-4596	83	48	ng	ng	PROPN
dpc-4596	83	49	/	/	SYM
dpc-4596	83	50	l.	l.	PROPN
dpc-4596	83	51	the	the	DET
dpc-4596	83	52	concentrations	concentration	NOUN
dpc-4596	83	53	calculated	calculate	VERB
dpc-4596	83	54	with	with	ADP
dpc-4596	83	55	the	the	DET
dpc-4596	83	56	logarithmic	logarithmic	ADJ
dpc-4596	83	57	curve	curve	NOUN
dpc-4596	83	58	were	be	AUX
dpc-4596	83	59	expressed	express	VERB
dpc-4596	83	60	in	in	ADP
dpc-4596	83	61	ng	ng	PROPN
dpc-4596	83	62	/	/	SYM
dpc-4596	83	63	l.	l.	PROPN
dpc-4596	83	64	statistical	statistical	ADJ
dpc-4596	83	65	analysis	analysis	NOUN
dpc-4596	83	66	the	the	DET
dpc-4596	83	67	sample	sample	NOUN
dpc-4596	83	68	size	size	NOUN
dpc-4596	83	69	was	be	AUX
dpc-4596	83	70	calculated	calculate	VERB
dpc-4596	83	71	using	use	VERB
dpc-4596	83	72	the	the	DET
dpc-4596	83	73	g*power	g*power	PROPN
dpc-4596	83	74	version	version	NOUN
dpc-4596	83	75	3.1.6	3.1.6	NUM
dpc-4596	83	76	program	program	NOUN
dpc-4596	83	77	.	.	PUNCT
dpc-4596	84	1	in	in	ADP
dpc-4596	84	2	light	light	NOUN
dpc-4596	84	3	of	of	ADP
dpc-4596	84	4	the	the	DET
dpc-4596	84	5	fact	fact	NOUN
dpc-4596	84	6	that	that	SCONJ
dpc-4596	84	7	a	a	DET
dpc-4596	84	8	large	large	ADJ
dpc-4596	84	9	effect	effect	NOUN
dpc-4596	84	10	size	size	NOUN
dpc-4596	84	11	(	(	PUNCT
dpc-4596	84	12	effect	effect	NOUN
dpc-4596	84	13	size	size	NOUN
dpc-4596	84	14	=	=	SYM
dpc-4596	84	15	0.8	0.8	NUM
dpc-4596	84	16	)	)	PUNCT
dpc-4596	84	17	between	between	ADP
dpc-4596	84	18	the	the	DET
dpc-4596	84	19	groups	group	NOUN
dpc-4596	84	20	would	would	AUX
dpc-4596	84	21	be	be	AUX
dpc-4596	84	22	deemed	deem	VERB
dpc-4596	84	23	acceptable	acceptable	ADJ
dpc-4596	84	24	,	,	PUNCT
dpc-4596	84	25	the	the	DET
dpc-4596	84	26	minimum	minimum	ADJ
dpc-4596	84	27	sample	sample	NOUN
dpc-4596	84	28	size	size	NOUN
dpc-4596	84	29	for	for	ADP
dpc-4596	84	30	95	95	NUM
dpc-4596	84	31	%	%	NOUN
dpc-4596	84	32	power	power	NOUN
dpc-4596	84	33	and	and	CCONJ
dpc-4596	84	34	an	an	DET
dpc-4596	84	35	alpha	alpha	NOUN
dpc-4596	84	36	significance	significance	NOUN
dpc-4596	84	37	level	level	NOUN
dpc-4596	84	38	of	of	ADP
dpc-4596	84	39	0.05	0.05	NUM
dpc-4596	84	40	was	be	AUX
dpc-4596	84	41	calculated	calculate	VERB
dpc-4596	84	42	as	as	ADP
dpc-4596	84	43	35	35	NUM
dpc-4596	84	44	patients	patient	NOUN
dpc-4596	84	45	and	and	CCONJ
dpc-4596	84	46	35	35	NUM
dpc-4596	84	47	controls	control	NOUN
dpc-4596	84	48	,	,	PUNCT
dpc-4596	84	49	resulting	result	VERB
dpc-4596	84	50	in	in	ADP
dpc-4596	84	51	a	a	DET
dpc-4596	84	52	total	total	NOUN
dpc-4596	84	53	of	of	ADP
dpc-4596	84	54	70	70	NUM
dpc-4596	84	55	cases	case	NOUN
dpc-4596	84	56	.	.	PUNCT
dpc-4596	85	1	the	the	DET
dpc-4596	85	2	study	study	NOUN
dpc-4596	85	3	was	be	AUX
dpc-4596	85	4	concluded	conclude	VERB
dpc-4596	85	5	with	with	ADP
dpc-4596	85	6	a	a	DET
dpc-4596	85	7	total	total	NOUN
dpc-4596	85	8	of	of	ADP
dpc-4596	85	9	80	80	NUM
dpc-4596	85	10	cases	case	NOUN
dpc-4596	85	11	,	,	PUNCT
dpc-4596	85	12	comprising	comprise	VERB
dpc-4596	85	13	40	40	NUM
dpc-4596	85	14	patients	patient	NOUN
dpc-4596	85	15	and	and	CCONJ
dpc-4596	85	16	40	40	NUM
dpc-4596	85	17	controls	control	NOUN
dpc-4596	85	18	.	.	PUNCT
dpc-4596	86	1	all	all	DET
dpc-4596	86	2	analyses	analysis	NOUN
dpc-4596	86	3	were	be	AUX
dpc-4596	86	4	conducted	conduct	VERB
dpc-4596	86	5	using	use	VERB
dpc-4596	86	6	the	the	DET
dpc-4596	86	7	ibm	ibm	PROPN
dpc-4596	86	8	statistical	statistical	ADJ
dpc-4596	86	9	package	package	NOUN
dpc-4596	86	10	for	for	ADP
dpc-4596	86	11	the	the	DET
dpc-4596	86	12	social	social	ADJ
dpc-4596	86	13	sciences	sciences	PROPN
dpc-4596	86	14	(	(	PUNCT
dpc-4596	86	15	spss	spss	PROPN
dpc-4596	86	16	)	)	PUNCT
dpc-4596	86	17	version	version	NOUN
dpc-4596	86	18	20.0	20.0	NUM
dpc-4596	86	19	.	.	PUNCT
dpc-4596	87	1	the	the	DET
dpc-4596	87	2	normality	normality	NOUN
dpc-4596	87	3	of	of	ADP
dpc-4596	87	4	the	the	DET
dpc-4596	87	5	distribution	distribution	NOUN
dpc-4596	87	6	of	of	ADP
dpc-4596	87	7	continuous	continuous	ADJ
dpc-4596	87	8	variables	variable	NOUN
dpc-4596	87	9	was	be	AUX
dpc-4596	87	10	evaluated	evaluate	VERB
dpc-4596	87	11	using	use	VERB
dpc-4596	87	12	the	the	DET
dpc-4596	87	13	kolmogorov	kolmogorov	ADJ
dpc-4596	87	14	-	-	PUNCT
dpc-4596	87	15	smirnov	smirnov	ADJ
dpc-4596	87	16	test	test	NOUN
dpc-4596	87	17	.	.	PUNCT
dpc-4596	88	1	data	datum	NOUN
dpc-4596	88	2	exhibiting	exhibit	VERB
dpc-4596	88	3	a	a	DET
dpc-4596	88	4	non	non	ADJ
dpc-4596	88	5	-	-	ADJ
dpc-4596	88	6	parametric	parametric	ADJ
dpc-4596	88	7	distribution	distribution	NOUN
dpc-4596	88	8	are	be	AUX
dpc-4596	88	9	expressed	express	VERB
dpc-4596	88	10	as	as	ADP
dpc-4596	88	11	median	median	NOUN
dpc-4596	88	12	(	(	PUNCT
dpc-4596	88	13	interquartile	interquartile	NOUN
dpc-4596	88	14	range	range	NOUN
dpc-4596	88	15	)	)	PUNCT
dpc-4596	88	16	,	,	PUNCT
dpc-4596	88	17	while	while	SCONJ
dpc-4596	88	18	categorical	categorical	ADJ
dpc-4596	88	19	variables	variable	NOUN
dpc-4596	88	20	are	be	AUX
dpc-4596	88	21	expressed	express	VERB
dpc-4596	88	22	as	as	ADP
dpc-4596	88	23	number	number	NOUN
dpc-4596	88	24	(	(	PUNCT
dpc-4596	88	25	percentage	percentage	NOUN
dpc-4596	88	26	)	)	PUNCT
dpc-4596	88	27	.	.	PUNCT
dpc-4596	89	1	the	the	DET
dpc-4596	89	2	independent	independent	ADJ
dpc-4596	89	3	samples	sample	NOUN
dpc-4596	89	4	were	be	AUX
dpc-4596	89	5	compared	compare	VERB
dpc-4596	89	6	using	use	VERB
dpc-4596	89	7	the	the	DET
dpc-4596	89	8	mann	mann	PROPN
dpc-4596	89	9	-	-	PUNCT
dpc-4596	89	10	whitney	whitney	PROPN
dpc-4596	89	11	u	u	PROPN
dpc-4596	89	12	test	test	NOUN
dpc-4596	89	13	.	.	PUNCT
dpc-4596	90	1	categorical	categorical	ADJ
dpc-4596	90	2	variables	variable	NOUN
dpc-4596	90	3	were	be	AUX
dpc-4596	90	4	analyzed	analyze	VERB
dpc-4596	90	5	using	use	VERB
dpc-4596	90	6	pearson	pearson	PROPN
dpc-4596	90	7	’s	’s	PART
dpc-4596	90	8	chi	chi	ADJ
dpc-4596	90	9	-	-	PUNCT
dpc-4596	90	10	square	square	ADJ
dpc-4596	90	11	test	test	NOUN
dpc-4596	90	12	.	.	PUNCT
dpc-4596	91	1	correlations	correlation	NOUN
dpc-4596	91	2	were	be	AUX
dpc-4596	91	3	calculated	calculate	VERB
dpc-4596	91	4	using	use	VERB
dpc-4596	91	5	the	the	DET
dpc-4596	91	6	spearman	spearman	NOUN
dpc-4596	91	7	correlation	correlation	NOUN
dpc-4596	91	8	coefficient	coefficient	NOUN
dpc-4596	91	9	.	.	PUNCT
dpc-4596	92	1	a	a	DET
dpc-4596	92	2	p	p	NOUN
dpc-4596	92	3	-	-	PUNCT
dpc-4596	92	4	value	value	NOUN
dpc-4596	92	5	of	of	ADP
dpc-4596	92	6	less	less	ADJ
dpc-4596	92	7	than	than	ADP
dpc-4596	92	8	0.05	0.05	NUM
dpc-4596	92	9	was	be	AUX
dpc-4596	92	10	considered	consider	VERB
dpc-4596	92	11	to	to	PART
dpc-4596	92	12	be	be	AUX
dpc-4596	92	13	statistically	statistically	ADV
dpc-4596	92	14	significant	significant	ADJ
dpc-4596	92	15	.	.	PUNCT
dpc-4596	93	1	results	result	VERB
dpc-4596	93	2	a	a	DET
dpc-4596	93	3	total	total	NOUN
dpc-4596	93	4	of	of	ADP
dpc-4596	93	5	80	80	NUM
dpc-4596	93	6	participants	participant	NOUN
dpc-4596	93	7	were	be	AUX
dpc-4596	93	8	included	include	VERB
dpc-4596	93	9	in	in	ADP
dpc-4596	93	10	the	the	DET
dpc-4596	93	11	study	study	NOUN
dpc-4596	93	12	,	,	PUNCT
dpc-4596	93	13	comprising	comprise	VERB
dpc-4596	93	14	40	40	NUM
dpc-4596	93	15	patients	patient	NOUN
dpc-4596	93	16	with	with	ADP
dpc-4596	93	17	plaque	plaque	NOUN
dpc-4596	93	18	psoriasis	psoriasis	NOUN
dpc-4596	93	19	and	and	CCONJ
dpc-4596	93	20	40	40	NUM
dpc-4596	93	21	non	non	ADJ
dpc-4596	93	22	-	-	ADJ
dpc-4596	93	23	psoriatic	psoriatic	ADJ
dpc-4596	93	24	volunteers	volunteer	NOUN
dpc-4596	93	25	.	.	PUNCT
dpc-4596	94	1	among	among	ADP
dpc-4596	94	2	the	the	DET
dpc-4596	94	3	patient	patient	NOUN
dpc-4596	94	4	cohort	cohort	NOUN
dpc-4596	94	5	,	,	PUNCT
dpc-4596	94	6	25	25	NUM
dpc-4596	94	7	individuals	individual	NOUN
dpc-4596	94	8	(	(	PUNCT
dpc-4596	94	9	62.5	62.5	NUM
dpc-4596	94	10	%	%	NOUN
dpc-4596	94	11	)	)	PUNCT
dpc-4596	94	12	exhibited	exhibit	VERB
dpc-4596	94	13	mild	mild	ADJ
dpc-4596	94	14	disease	disease	NOUN
dpc-4596	94	15	,	,	PUNCT
dpc-4596	94	16	while	while	SCONJ
dpc-4596	94	17	15	15	NUM
dpc-4596	94	18	(	(	PUNCT
dpc-4596	94	19	37.5	37.5	NUM
dpc-4596	94	20	%	%	NOUN
dpc-4596	94	21	)	)	PUNCT
dpc-4596	94	22	demonstrated	demonstrate	VERB
dpc-4596	94	23	moderate	moderate	ADJ
dpc-4596	94	24	-	-	PUNCT
dpc-4596	94	25	to	to	ADP
dpc-4596	94	26	-severe	-severe	NOUN
dpc-4596	94	27	disease	disease	NOUN
dpc-4596	94	28	severity	severity	NOUN
dpc-4596	94	29	,	,	PUNCT
dpc-4596	94	30	as	as	SCONJ
dpc-4596	94	31	determined	determine	VERB
dpc-4596	94	32	by	by	ADP
dpc-4596	94	33	pasi	pasi	NOUN
dpc-4596	94	34	scores	score	NOUN
dpc-4596	94	35	.	.	PUNCT
dpc-4596	95	1	there	there	PRON
dpc-4596	95	2	were	be	VERB
dpc-4596	95	3	no	no	DET
dpc-4596	95	4	substantial	substantial	ADJ
dpc-4596	95	5	differences	difference	NOUN
dpc-4596	95	6	in	in	ADP
dpc-4596	95	7	age	age	NOUN
dpc-4596	95	8	and	and	CCONJ
dpc-4596	95	9	sex	sex	NOUN
dpc-4596	95	10	ratio	ratio	NOUN
dpc-4596	95	11	for	for	ADP
dpc-4596	95	12	each	each	DET
dpc-4596	95	13	variable	variable	NOUN
dpc-4596	95	14	between	between	ADP
dpc-4596	95	15	patients	patient	NOUN
dpc-4596	95	16	with	with	ADP
dpc-4596	95	17	plaque	plaque	NOUN
dpc-4596	95	18	psoriasis	psoriasis	NOUN
dpc-4596	95	19	and	and	CCONJ
dpc-4596	95	20	controls	control	NOUN
dpc-4596	95	21	(	(	PUNCT
dpc-4596	95	22	p=0.996	p=0.996	NOUN
dpc-4596	95	23	,	,	PUNCT
dpc-4596	95	24	p=1.0	p=1.0	ADJ
dpc-4596	95	25	,	,	PUNCT
dpc-4596	95	26	respectively	respectively	ADV
dpc-4596	95	27	)	)	PUNCT
dpc-4596	95	28	.	.	PUNCT
dpc-4596	96	1	the	the	DET
dpc-4596	96	2	median	median	PROPN
dpc-4596	96	3	(	(	PUNCT
dpc-4596	96	4	iqr	iqr	NOUN
dpc-4596	96	5	)	)	PUNCT
dpc-4596	96	6	age	age	NOUN
dpc-4596	96	7	of	of	ADP
dpc-4596	96	8	patients	patient	NOUN
dpc-4596	96	9	with	with	ADP
dpc-4596	96	10	plaque	plaque	NOUN
dpc-4596	96	11	psoriasis	psoriasis	NOUN
dpc-4596	96	12	was	be	AUX
dpc-4596	96	13	39	39	NUM
dpc-4596	96	14	(	(	PUNCT
dpc-4596	96	15	19	19	NUM
dpc-4596	96	16	)	)	PUNCT
dpc-4596	96	17	years	year	NOUN
dpc-4596	96	18	,	,	PUNCT
dpc-4596	96	19	with	with	ADP
dpc-4596	96	20	29	29	NUM
dpc-4596	96	21	(	(	PUNCT
dpc-4596	96	22	72.5	72.5	NUM
dpc-4596	96	23	%	%	NOUN
dpc-4596	96	24	)	)	PUNCT
dpc-4596	96	25	males	male	NOUN
dpc-4596	96	26	and	and	CCONJ
dpc-4596	96	27	11	11	NUM
dpc-4596	96	28	(	(	PUNCT
dpc-4596	96	29	27.5	27.5	NUM
dpc-4596	96	30	%	%	NOUN
dpc-4596	96	31	)	)	PUNCT
dpc-4596	96	32	females	female	NOUN
dpc-4596	96	33	.	.	PUNCT
dpc-4596	97	1	the	the	DET
dpc-4596	97	2	median	median	PROPN
dpc-4596	97	3	(	(	PUNCT
dpc-4596	97	4	iqr	iqr	NOUN
dpc-4596	97	5	)	)	PUNCT
dpc-4596	97	6	age	age	NOUN
dpc-4596	97	7	of	of	ADP
dpc-4596	97	8	controls	control	NOUN
dpc-4596	97	9	was	be	AUX
dpc-4596	97	10	39.5	39.5	NUM
dpc-4596	97	11	(	(	PUNCT
dpc-4596	97	12	21	21	NUM
dpc-4596	97	13	)	)	PUNCT
dpc-4596	97	14	years	year	NOUN
dpc-4596	97	15	,	,	PUNCT
dpc-4596	97	16	with	with	ADP
dpc-4596	97	17	29	29	NUM
dpc-4596	97	18	(	(	PUNCT
dpc-4596	97	19	72.5	72.5	NUM
dpc-4596	97	20	%	%	NOUN
dpc-4596	97	21	)	)	PUNCT
dpc-4596	97	22	males	male	NOUN
dpc-4596	97	23	and	and	CCONJ
dpc-4596	97	24	11	11	NUM
dpc-4596	97	25	(	(	PUNCT
dpc-4596	97	26	27.5	27.5	NUM
dpc-4596	97	27	%	%	NOUN
dpc-4596	97	28	)	)	PUNCT
dpc-4596	97	29	females	female	NOUN
dpc-4596	97	30	(	(	PUNCT
dpc-4596	97	31	table	table	NOUN
dpc-4596	97	32	1	1	NUM
dpc-4596	97	33	)	)	PUNCT
dpc-4596	97	34	.	.	PUNCT
dpc-4596	98	1	the	the	DET
dpc-4596	98	2	median	median	PROPN
dpc-4596	98	3	(	(	PUNCT
dpc-4596	98	4	iqr	iqr	NOUN
dpc-4596	98	5	)	)	PUNCT
dpc-4596	98	6	serum	serum	VERB
dpc-4596	98	7	mtorc1	mtorc1	NOUN
dpc-4596	98	8	concentration	concentration	NOUN
dpc-4596	98	9	in	in	ADP
dpc-4596	98	10	patients	patient	NOUN
dpc-4596	98	11	with	with	ADP
dpc-4596	98	12	plaque	plaque	NOUN
dpc-4596	98	13	psoriasis	psoriasis	NOUN
dpc-4596	98	14	was	be	AUX
dpc-4596	98	15	significantly	significantly	ADV
dpc-4596	98	16	lower	low	ADJ
dpc-4596	98	17	than	than	ADP
dpc-4596	98	18	that	that	PRON
dpc-4596	98	19	of	of	ADP
dpc-4596	98	20	the	the	DET
dpc-4596	98	21	controls	control	NOUN
dpc-4596	98	22	[	[	X
dpc-4596	98	23	158.1	158.1	NUM
dpc-4596	98	24	(	(	PUNCT
dpc-4596	98	25	129.75	129.75	NUM
dpc-4596	98	26	)	)	PUNCT
dpc-4596	98	27	ng	ng	PROPN
dpc-4596	98	28	/	/	SYM
dpc-4596	98	29	l	l	PROPN
dpc-4596	98	30	;	;	PUNCT
dpc-4596	98	31	266.4	266.4	NUM
dpc-4596	98	32	(	(	PUNCT
dpc-4596	98	33	471.7	471.7	NUM
dpc-4596	98	34	)	)	PUNCT
dpc-4596	98	35	ng	ng	PROPN
dpc-4596	98	36	/	/	SYM
dpc-4596	98	37	l	l	PROPN
dpc-4596	98	38	,	,	PUNCT
dpc-4596	98	39	p=0,001	p=0,001	NOUN
dpc-4596	98	40	]	]	PUNCT
dpc-4596	98	41	.	.	PUNCT
dpc-4596	99	1	similarly	similarly	ADV
dpc-4596	99	2	,	,	PUNCT
dpc-4596	99	3	serum	serum	PROPN
dpc-4596	99	4	mtorc2	mtorc2	PROPN
dpc-4596	99	5	concentration	concentration	NOUN
dpc-4596	99	6	in	in	ADP
dpc-4596	99	7	patients	patient	NOUN
dpc-4596	99	8	with	with	ADP
dpc-4596	99	9	plaque	plaque	NOUN
dpc-4596	99	10	psoriasis	psoriasis	NOUN
dpc-4596	99	11	was	be	AUX
dpc-4596	99	12	significantly	significantly	ADV
dpc-4596	99	13	lower	low	ADJ
dpc-4596	99	14	than	than	ADP
dpc-4596	99	15	that	that	PRON
dpc-4596	99	16	of	of	ADP
dpc-4596	99	17	the	the	DET
dpc-4596	99	18	controls	control	NOUN
dpc-4596	99	19	[	[	PUNCT
dpc-4596	99	20	127.4	127.4	NUM
dpc-4596	99	21	(	(	PUNCT
dpc-4596	99	22	95.1	95.1	NUM
dpc-4596	99	23	)	)	PUNCT
dpc-4596	99	24	ng	ng	PROPN
dpc-4596	99	25	/	/	SYM
dpc-4596	99	26	l	l	PROPN
dpc-4596	99	27	;	;	PUNCT
dpc-4596	99	28	219.3	219.3	NUM
dpc-4596	99	29	(	(	PUNCT
dpc-4596	99	30	506.5	506.5	NUM
dpc-4596	99	31	)	)	PUNCT
dpc-4596	99	32	ng	ng	PROPN
dpc-4596	99	33	/	/	SYM
dpc-4596	99	34	l	l	NOUN
dpc-4596	99	35	,	,	PUNCT
dpc-4596	99	36	p=0.024	p=0.024	X
dpc-4596	99	37	]	]	PUNCT
dpc-4596	99	38	(	(	PUNCT
dpc-4596	99	39	table	table	NOUN
dpc-4596	99	40	2	2	NUM
dpc-4596	99	41	)	)	PUNCT
dpc-4596	99	42	.	.	PUNCT
dpc-4596	100	1	when	when	SCONJ
dpc-4596	100	2	patients	patient	NOUN
dpc-4596	100	3	with	with	ADP
dpc-4596	100	4	psoriasis	psoriasis	NOUN
dpc-4596	100	5	were	be	AUX
dpc-4596	100	6	examined	examine	VERB
dpc-4596	100	7	according	accord	VERB
dpc-4596	100	8	to	to	ADP
dpc-4596	100	9	disease	disease	NOUN
dpc-4596	100	10	severity	severity	NOUN
dpc-4596	100	11	,	,	PUNCT
dpc-4596	100	12	no	no	DET
dpc-4596	100	13	statistically	statistically	ADV
dpc-4596	100	14	significant	significant	ADJ
dpc-4596	100	15	difference	difference	NOUN
dpc-4596	100	16	was	be	AUX
dpc-4596	100	17	observed	observe	VERB
dpc-4596	100	18	between	between	ADP
dpc-4596	100	19	the	the	DET
dpc-4596	100	20	mild	mild	ADJ
dpc-4596	100	21	and	and	CCONJ
dpc-4596	100	22	moderate	moderate	ADJ
dpc-4596	100	23	-	-	PUNCT
dpc-4596	100	24	to	to	ADP
dpc-4596	100	25	-	-	PUNCT
dpc-4596	100	26	severe	severe	ADJ
dpc-4596	100	27	plaque	plaque	NOUN
dpc-4596	100	28	psoriasis	psoriasis	NOUN
dpc-4596	100	29	groups	group	NOUN
dpc-4596	100	30	in	in	ADP
dpc-4596	100	31	terms	term	NOUN
dpc-4596	100	32	of	of	ADP
dpc-4596	100	33	mtorc1	mtorc1	NOUN
dpc-4596	100	34	and	and	CCONJ
dpc-4596	100	35	mtorc2	mtorc2	PROPN
dpc-4596	100	36	levels	level	NOUN
dpc-4596	100	37	.	.	PUNCT
dpc-4596	101	1	the	the	DET
dpc-4596	101	2	median	median	PROPN
dpc-4596	101	3	(	(	PUNCT
dpc-4596	101	4	iqr	iqr	NOUN
dpc-4596	101	5	)	)	PUNCT
dpc-4596	101	6	serum	serum	VERB
dpc-4596	101	7	mtorc1	mtorc1	NOUN
dpc-4596	101	8	concentration	concentration	NOUN
dpc-4596	101	9	in	in	ADP
dpc-4596	101	10	patients	patient	NOUN
dpc-4596	101	11	with	with	ADP
dpc-4596	101	12	mild	mild	ADJ
dpc-4596	101	13	psoriasis	psoriasis	NOUN
dpc-4596	101	14	was	be	AUX
dpc-4596	101	15	4	4	NUM
dpc-4596	101	16	original	original	ADJ
dpc-4596	101	17	article	article	NOUN
dpc-4596	101	18	|	|	ADV
dpc-4596	101	19	dermatol	dermatol	ADJ
dpc-4596	101	20	pract	pract	NOUN
dpc-4596	101	21	concept	concept	NOUN
dpc-4596	101	22	.	.	PUNCT
dpc-4596	102	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	102	2	table	table	NOUN
dpc-4596	102	3	1	1	NUM
dpc-4596	102	4	.	.	PUNCT
dpc-4596	103	1	demographic	demographic	ADJ
dpc-4596	103	2	characteristics	characteristic	NOUN
dpc-4596	103	3	of	of	ADP
dpc-4596	103	4	subjects	subject	NOUN
dpc-4596	103	5	.	.	PUNCT
dpc-4596	104	1	plaque	plaque	NOUN
dpc-4596	104	2	psoriasis	psoriasis	NOUN
dpc-4596	104	3	(	(	PUNCT
dpc-4596	104	4	n=40	n=40	ADJ
dpc-4596	104	5	)	)	PUNCT
dpc-4596	104	6	controls	control	NOUN
dpc-4596	104	7	(	(	PUNCT
dpc-4596	104	8	n=40	n=40	ADJ
dpc-4596	104	9	)	)	PUNCT
dpc-4596	104	10	p	p	NOUN
dpc-4596	104	11	age	age	NOUN
dpc-4596	104	12	,	,	PUNCT
dpc-4596	104	13	years	year	NOUN
dpc-4596	104	14	median	median	NOUN
dpc-4596	104	15	(	(	PUNCT
dpc-4596	104	16	iqr	iqr	NOUN
dpc-4596	104	17	)	)	PUNCT
dpc-4596	104	18	39	39	NUM
dpc-4596	104	19	(	(	PUNCT
dpc-4596	104	20	19	19	NUM
dpc-4596	104	21	)	)	PUNCT
dpc-4596	104	22	39.5	39.5	NUM
dpc-4596	104	23	(	(	PUNCT
dpc-4596	104	24	21	21	NUM
dpc-4596	104	25	)	)	PUNCT
dpc-4596	104	26	*	*	PUNCT
dpc-4596	104	27	0,996	0,996	NUM
dpc-4596	104	28	sex	sex	NOUN
dpc-4596	104	29	,	,	PUNCT
dpc-4596	104	30	n	n	PROPN
dpc-4596	104	31	(	(	PUNCT
dpc-4596	104	32	%	%	INTJ
dpc-4596	104	33	)	)	PUNCT
dpc-4596	104	34	male	male	ADJ
dpc-4596	104	35	female	female	ADJ
dpc-4596	104	36	29	29	NUM
dpc-4596	104	37	(	(	PUNCT
dpc-4596	104	38	72.5	72.5	NUM
dpc-4596	104	39	)	)	PUNCT
dpc-4596	104	40	11	11	NUM
dpc-4596	104	41	(	(	PUNCT
dpc-4596	104	42	27.5	27.5	NUM
dpc-4596	104	43	)	)	SYM
dpc-4596	104	44	29	29	NUM
dpc-4596	104	45	(	(	PUNCT
dpc-4596	104	46	72.5	72.5	NUM
dpc-4596	104	47	)	)	PUNCT
dpc-4596	104	48	11	11	NUM
dpc-4596	104	49	(	(	PUNCT
dpc-4596	104	50	27.5	27.5	NUM
dpc-4596	104	51	)	)	PUNCT
dpc-4596	104	52	*	*	PUNCT
dpc-4596	105	1	*	*	PUNCT
dpc-4596	105	2	1,0	1,0	NUM
dpc-4596	105	3	psoriasis	psoriasis	NOUN
dpc-4596	105	4	severity	severity	NOUN
dpc-4596	105	5	,	,	PUNCT
dpc-4596	105	6	n	n	PROPN
dpc-4596	105	7	(	(	PUNCT
dpc-4596	105	8	%	%	INTJ
dpc-4596	105	9	)	)	PUNCT
dpc-4596	105	10	mild	mild	ADJ
dpc-4596	105	11	moderate	moderate	ADJ
dpc-4596	105	12	-	-	PUNCT
dpc-4596	105	13	severe	severe	ADJ
dpc-4596	105	14	25	25	NUM
dpc-4596	105	15	(	(	PUNCT
dpc-4596	105	16	62.5	62.5	NUM
dpc-4596	105	17	)	)	PUNCT
dpc-4596	105	18	15	15	NUM
dpc-4596	105	19	(	(	PUNCT
dpc-4596	105	20	37.5	37.5	NUM
dpc-4596	105	21	)	)	PUNCT
dpc-4596	105	22	disease	disease	NOUN
dpc-4596	105	23	duration	duration	NOUN
dpc-4596	105	24	,	,	PUNCT
dpc-4596	105	25	years	year	NOUN
dpc-4596	105	26	median	median	NOUN
dpc-4596	105	27	(	(	PUNCT
dpc-4596	105	28	iqr	iqr	NOUN
dpc-4596	105	29	)	)	PUNCT
dpc-4596	105	30	10	10	NUM
dpc-4596	105	31	(	(	PUNCT
dpc-4596	105	32	13.5	13.5	NUM
dpc-4596	105	33	)	)	PUNCT
dpc-4596	105	34	*	*	PUNCT
dpc-4596	106	1	p	p	NOUN
dpc-4596	106	2	-	-	PUNCT
dpc-4596	106	3	value	value	NOUN
dpc-4596	106	4	for	for	ADP
dpc-4596	106	5	the	the	DET
dpc-4596	106	6	mann	mann	PROPN
dpc-4596	106	7	-	-	PUNCT
dpc-4596	106	8	whitney	whitney	PROPN
dpc-4596	106	9	u	u	PROPN
dpc-4596	106	10	test	test	NOUN
dpc-4596	106	11	comparing	compare	VERB
dpc-4596	106	12	age	age	NOUN
dpc-4596	106	13	between	between	ADP
dpc-4596	106	14	patients	patient	NOUN
dpc-4596	106	15	with	with	ADP
dpc-4596	106	16	psoriasis	psoriasis	NOUN
dpc-4596	106	17	and	and	CCONJ
dpc-4596	106	18	healthy	healthy	ADJ
dpc-4596	106	19	controls	control	NOUN
dpc-4596	106	20	.	.	PUNCT
dpc-4596	107	1	*	*	PUNCT
dpc-4596	107	2	*	*	PUNCT
dpc-4596	107	3	p	p	NOUN
dpc-4596	107	4	-	-	PUNCT
dpc-4596	107	5	value	value	NOUN
dpc-4596	107	6	for	for	ADP
dpc-4596	107	7	the	the	DET
dpc-4596	107	8	pearson	pearson	PROPN
dpc-4596	107	9	’s	’s	PART
dpc-4596	107	10	chi	chi	ADJ
dpc-4596	107	11	-	-	PUNCT
dpc-4596	107	12	square	square	ADJ
dpc-4596	107	13	test	test	NOUN
dpc-4596	107	14	comparing	compare	VERB
dpc-4596	107	15	sex	sex	NOUN
dpc-4596	107	16	ratio	ratio	NOUN
dpc-4596	107	17	between	between	ADP
dpc-4596	107	18	patients	patient	NOUN
dpc-4596	107	19	with	with	ADP
dpc-4596	107	20	psoriasis	psoriasis	NOUN
dpc-4596	107	21	and	and	CCONJ
dpc-4596	107	22	healthy	healthy	ADJ
dpc-4596	107	23	controls	control	NOUN
dpc-4596	107	24	.	.	PUNCT
dpc-4596	108	1	table	table	NOUN
dpc-4596	108	2	2	2	NUM
dpc-4596	108	3	.	.	PUNCT
dpc-4596	109	1	mtorc1	mtorc1	NOUN
dpc-4596	109	2	and	and	CCONJ
dpc-4596	109	3	mtorc2	mtorc2	NOUN
dpc-4596	109	4	levels	level	NOUN
dpc-4596	109	5	of	of	ADP
dpc-4596	109	6	the	the	DET
dpc-4596	109	7	patient	patient	NOUN
dpc-4596	109	8	with	with	ADP
dpc-4596	109	9	plaque	plaque	NOUN
dpc-4596	109	10	psoriasis	psoriasis	NOUN
dpc-4596	109	11	and	and	CCONJ
dpc-4596	109	12	control	control	NOUN
dpc-4596	109	13	group	group	NOUN
dpc-4596	109	14	.	.	PUNCT
dpc-4596	110	1	psoriasis	psoriasis	NOUN
dpc-4596	110	2	(	(	PUNCT
dpc-4596	110	3	n=	n=	ADJ
dpc-4596	110	4	40	40	NUM
dpc-4596	110	5	)	)	PUNCT
dpc-4596	110	6	controls	control	NOUN
dpc-4596	110	7	(	(	PUNCT
dpc-4596	110	8	n=	n=	ADJ
dpc-4596	110	9	40	40	NUM
dpc-4596	110	10	)	)	PUNCT
dpc-4596	110	11	p	p	NOUN
dpc-4596	110	12	psoriasis	psoriasis	NOUN
dpc-4596	110	13	severity	severity	NOUN
dpc-4596	110	14	p	p	X
dpc-4596	110	15	mild	mild	ADJ
dpc-4596	110	16	(	(	PUNCT
dpc-4596	110	17	n=25	n=25	NOUN
dpc-4596	110	18	)	)	PUNCT
dpc-4596	110	19	moderate	moderate	ADJ
dpc-4596	110	20	to	to	ADP
dpc-4596	110	21	severe	severe	ADJ
dpc-4596	110	22	(	(	PUNCT
dpc-4596	110	23	n=15	n=15	NUM
dpc-4596	110	24	)	)	PUNCT
dpc-4596	110	25	mtorc1	mtorc1	NOUN
dpc-4596	110	26	,	,	PUNCT
dpc-4596	110	27	ng	ng	PROPN
dpc-4596	110	28	/	/	SYM
dpc-4596	110	29	l	l	PROPN
dpc-4596	110	30	median	median	PROPN
dpc-4596	110	31	(	(	PUNCT
dpc-4596	110	32	iqr	iqr	PROPN
dpc-4596	110	33	)	)	PUNCT
dpc-4596	110	34	158.1	158.1	NUM
dpc-4596	110	35	(	(	PUNCT
dpc-4596	110	36	129.75	129.75	NUM
dpc-4596	110	37	)	)	PUNCT
dpc-4596	110	38	266.4	266.4	NUM
dpc-4596	110	39	(	(	PUNCT
dpc-4596	110	40	471.7	471.7	NUM
dpc-4596	110	41	)	)	PUNCT
dpc-4596	110	42	0,001	0,001	NUM
dpc-4596	110	43	*	*	NUM
dpc-4596	110	44	159.5	159.5	NUM
dpc-4596	110	45	(	(	PUNCT
dpc-4596	110	46	181.5	181.5	NUM
dpc-4596	110	47	)	)	PUNCT
dpc-4596	110	48	156.7	156.7	NUM
dpc-4596	110	49	(	(	PUNCT
dpc-4596	110	50	103.4	103.4	NUM
dpc-4596	110	51	)	)	PUNCT
dpc-4596	110	52	0,878	0,878	NUM
dpc-4596	110	53	*	*	SYM
dpc-4596	110	54	mtorc2	mtorc2	PROPN
dpc-4596	110	55	,	,	PUNCT
dpc-4596	110	56	ng	ng	PROPN
dpc-4596	110	57	/	/	SYM
dpc-4596	110	58	l	l	PROPN
dpc-4596	110	59	median	median	PROPN
dpc-4596	110	60	(	(	PUNCT
dpc-4596	110	61	iqr	iqr	PROPN
dpc-4596	110	62	)	)	PUNCT
dpc-4596	110	63	127.4	127.4	NUM
dpc-4596	110	64	(	(	PUNCT
dpc-4596	110	65	95.1	95.1	NUM
dpc-4596	110	66	)	)	PUNCT
dpc-4596	110	67	219.3	219.3	NUM
dpc-4596	110	68	(	(	PUNCT
dpc-4596	110	69	506.5	506.5	NUM
dpc-4596	110	70	)	)	PUNCT
dpc-4596	110	71	0,024	0,024	NOUN
dpc-4596	110	72	*	*	SYM
dpc-4596	110	73	127	127	NUM
dpc-4596	110	74	(	(	PUNCT
dpc-4596	110	75	109.9	109.9	NUM
dpc-4596	110	76	)	)	PUNCT
dpc-4596	110	77	127.8	127.8	NUM
dpc-4596	110	78	(	(	PUNCT
dpc-4596	110	79	91	91	NUM
dpc-4596	110	80	)	)	PUNCT
dpc-4596	110	81	0,737	0,737	NUM
dpc-4596	110	82	*	*	PUNCT
dpc-4596	110	83	*	*	PUNCT
dpc-4596	110	84	mann	mann	PROPN
dpc-4596	110	85	-	-	PUNCT
dpc-4596	110	86	whitney	whitney	PROPN
dpc-4596	110	87	u	u	PROPN
dpc-4596	110	88	test	test	VERB
dpc-4596	110	89	159.0	159.0	NUM
dpc-4596	110	90	(	(	PUNCT
dpc-4596	110	91	181.5	181.5	NUM
dpc-4596	110	92	)	)	PUNCT
dpc-4596	110	93	ng	ng	PROPN
dpc-4596	110	94	/	/	SYM
dpc-4596	110	95	l	l	PROPN
dpc-4596	110	96	,	,	PUNCT
dpc-4596	110	97	while	while	SCONJ
dpc-4596	110	98	in	in	ADP
dpc-4596	110	99	those	those	PRON
dpc-4596	110	100	with	with	ADP
dpc-4596	110	101	moderate	moderate	ADJ
dpc-4596	110	102	-	-	PUNCT
dpc-4596	110	103	to	to	ADP
dpc-4596	110	104	-	-	PUNCT
dpc-4596	110	105	severe	severe	ADJ
dpc-4596	110	106	psoriasis	psoriasis	NOUN
dpc-4596	110	107	,	,	PUNCT
dpc-4596	110	108	it	it	PRON
dpc-4596	110	109	was	be	AUX
dpc-4596	110	110	156.7	156.7	NUM
dpc-4596	110	111	(	(	PUNCT
dpc-4596	110	112	103.4	103.4	NUM
dpc-4596	110	113	)	)	PUNCT
dpc-4596	110	114	ng	ng	PROPN
dpc-4596	110	115	/	/	SYM
dpc-4596	110	116	l.	l.	PROPN
dpc-4596	110	117	the	the	DET
dpc-4596	110	118	p	p	NOUN
dpc-4596	110	119	-	-	PUNCT
dpc-4596	110	120	value	value	NOUN
dpc-4596	110	121	for	for	ADP
dpc-4596	110	122	this	this	DET
dpc-4596	110	123	comparison	comparison	NOUN
dpc-4596	110	124	was	be	AUX
dpc-4596	110	125	0,878	0,878	NUM
dpc-4596	110	126	.	.	PUNCT
dpc-4596	111	1	the	the	DET
dpc-4596	111	2	median	median	PROPN
dpc-4596	111	3	(	(	PUNCT
dpc-4596	111	4	iqr	iqr	NOUN
dpc-4596	111	5	)	)	PUNCT
dpc-4596	111	6	serum	serum	PROPN
dpc-4596	111	7	mtorc2	mtorc2	PROPN
dpc-4596	111	8	concentration	concentration	NOUN
dpc-4596	111	9	in	in	ADP
dpc-4596	111	10	patients	patient	NOUN
dpc-4596	111	11	with	with	ADP
dpc-4596	111	12	mild	mild	ADJ
dpc-4596	111	13	psoriasis	psoriasis	NOUN
dpc-4596	111	14	was	be	AUX
dpc-4596	111	15	127.0	127.0	NUM
dpc-4596	111	16	(	(	PUNCT
dpc-4596	111	17	109.9	109.9	NUM
dpc-4596	111	18	)	)	PUNCT
dpc-4596	111	19	ng	ng	PROPN
dpc-4596	111	20	/	/	SYM
dpc-4596	111	21	l	l	PROPN
dpc-4596	111	22	,	,	PUNCT
dpc-4596	111	23	while	while	SCONJ
dpc-4596	111	24	in	in	ADP
dpc-4596	111	25	those	those	PRON
dpc-4596	111	26	with	with	ADP
dpc-4596	111	27	moderate	moderate	ADJ
dpc-4596	111	28	to	to	ADP
dpc-4596	111	29	severe	severe	ADJ
dpc-4596	111	30	psoriasis	psoriasis	NOUN
dpc-4596	111	31	,	,	PUNCT
dpc-4596	111	32	it	it	PRON
dpc-4596	111	33	was	be	AUX
dpc-4596	111	34	127.8	127.8	NUM
dpc-4596	111	35	(	(	PUNCT
dpc-4596	111	36	91	91	NUM
dpc-4596	111	37	)	)	PUNCT
dpc-4596	111	38	ng	ng	PROPN
dpc-4596	111	39	/	/	SYM
dpc-4596	111	40	l.	l.	PROPN
dpc-4596	111	41	the	the	DET
dpc-4596	111	42	p	p	NOUN
dpc-4596	111	43	-	-	PUNCT
dpc-4596	111	44	value	value	NOUN
dpc-4596	111	45	for	for	ADP
dpc-4596	111	46	this	this	DET
dpc-4596	111	47	comparison	comparison	NOUN
dpc-4596	111	48	was	be	AUX
dpc-4596	111	49	0,737	0,737	NUM
dpc-4596	111	50	(	(	PUNCT
dpc-4596	111	51	table	table	NOUN
dpc-4596	111	52	2	2	NUM
dpc-4596	111	53	)	)	PUNCT
dpc-4596	111	54	.	.	PUNCT
dpc-4596	112	1	a	a	DET
dpc-4596	112	2	strong	strong	ADJ
dpc-4596	112	3	positive	positive	ADJ
dpc-4596	112	4	correlation	correlation	NOUN
dpc-4596	112	5	was	be	AUX
dpc-4596	112	6	identified	identify	VERB
dpc-4596	112	7	between	between	ADP
dpc-4596	112	8	serum	serum	NOUN
dpc-4596	112	9	mtorc1	mtorc1	NOUN
dpc-4596	112	10	and	and	CCONJ
dpc-4596	112	11	mtorc2	mtorc2	NOUN
dpc-4596	112	12	levels	level	NOUN
dpc-4596	112	13	(	(	PUNCT
dpc-4596	112	14	p=0.001	p=0.001	NUM
dpc-4596	112	15	,	,	PUNCT
dpc-4596	112	16	r=0.826	r=0.826	PUNCT
dpc-4596	112	17	)	)	PUNCT
dpc-4596	112	18	(	(	PUNCT
dpc-4596	112	19	figure	figure	NOUN
dpc-4596	112	20	1	1	NUM
dpc-4596	112	21	)	)	PUNCT
dpc-4596	112	22	.	.	PUNCT
dpc-4596	113	1	no	no	DET
dpc-4596	113	2	significant	significant	ADJ
dpc-4596	113	3	correlation	correlation	NOUN
dpc-4596	113	4	was	be	AUX
dpc-4596	113	5	observed	observe	VERB
dpc-4596	113	6	between	between	ADP
dpc-4596	113	7	serum	serum	NOUN
dpc-4596	113	8	mtorc1	mtorc1	NOUN
dpc-4596	113	9	and	and	CCONJ
dpc-4596	113	10	mtorc2	mtorc2	NOUN
dpc-4596	113	11	levels	level	NOUN
dpc-4596	113	12	and	and	CCONJ
dpc-4596	113	13	age	age	NOUN
dpc-4596	113	14	,	,	PUNCT
dpc-4596	113	15	sex	sex	NOUN
dpc-4596	113	16	,	,	PUNCT
dpc-4596	113	17	pasi	pasi	NOUN
dpc-4596	113	18	scores	score	NOUN
dpc-4596	113	19	,	,	PUNCT
dpc-4596	113	20	crp	crp	PROPN
dpc-4596	113	21	,	,	PUNCT
dpc-4596	113	22	or	or	CCONJ
dpc-4596	113	23	total	total	ADJ
dpc-4596	113	24	cholesterol	cholesterol	NOUN
dpc-4596	113	25	levels	level	NOUN
dpc-4596	113	26	(	(	PUNCT
dpc-4596	113	27	p	p	X
dpc-4596	113	28	>	>	X
dpc-4596	113	29	0.05	0.05	NUM
dpc-4596	113	30	)	)	PUNCT
dpc-4596	113	31	.	.	PUNCT
dpc-4596	114	1	duration	duration	NOUN
dpc-4596	114	2	of	of	ADP
dpc-4596	114	3	the	the	DET
dpc-4596	114	4	disease	disease	NOUN
dpc-4596	114	5	the	the	DET
dpc-4596	114	6	median	median	PROPN
dpc-4596	114	7	(	(	PUNCT
dpc-4596	114	8	iqr	iqr	NOUN
dpc-4596	114	9	)	)	PUNCT
dpc-4596	114	10	disease	disease	NOUN
dpc-4596	114	11	duration	duration	NOUN
dpc-4596	114	12	for	for	ADP
dpc-4596	114	13	all	all	DET
dpc-4596	114	14	patients	patient	NOUN
dpc-4596	114	15	with	with	ADP
dpc-4596	114	16	plaque	plaque	NOUN
dpc-4596	114	17	psoriasis	psoriasis	NOUN
dpc-4596	114	18	,	,	PUNCT
dpc-4596	114	19	those	those	PRON
dpc-4596	114	20	with	with	ADP
dpc-4596	114	21	mild	mild	ADJ
dpc-4596	114	22	plaque	plaque	NOUN
dpc-4596	114	23	psoriasis	psoriasis	NOUN
dpc-4596	114	24	,	,	PUNCT
dpc-4596	114	25	and	and	CCONJ
dpc-4596	114	26	those	those	PRON
dpc-4596	114	27	with	with	ADP
dpc-4596	114	28	moderate	moderate	ADJ
dpc-4596	114	29	-	-	PUNCT
dpc-4596	114	30	to	to	ADP
dpc-4596	114	31	-	-	PUNCT
dpc-4596	114	32	severe	severe	ADJ
dpc-4596	114	33	plaque	plaque	NOUN
dpc-4596	114	34	psoriasis	psoriasis	NOUN
dpc-4596	114	35	was	be	AUX
dpc-4596	114	36	10	10	NUM
dpc-4596	114	37	(	(	PUNCT
dpc-4596	114	38	13.5	13.5	NUM
dpc-4596	114	39	)	)	PUNCT
dpc-4596	114	40	years	year	NOUN
dpc-4596	114	41	,	,	PUNCT
dpc-4596	114	42	10	10	NUM
dpc-4596	114	43	(	(	PUNCT
dpc-4596	114	44	15	15	NUM
dpc-4596	114	45	)	)	PUNCT
dpc-4596	114	46	years	year	NOUN
dpc-4596	114	47	,	,	PUNCT
dpc-4596	114	48	and	and	CCONJ
dpc-4596	114	49	13	13	NUM
dpc-4596	114	50	(	(	PUNCT
dpc-4596	114	51	11	11	NUM
dpc-4596	114	52	)	)	PUNCT
dpc-4596	114	53	years	year	NOUN
dpc-4596	114	54	,	,	PUNCT
dpc-4596	114	55	respectively	respectively	ADV
dpc-4596	114	56	.	.	PUNCT
dpc-4596	115	1	a	a	DET
dpc-4596	115	2	negative	negative	ADJ
dpc-4596	115	3	correlation	correlation	NOUN
dpc-4596	115	4	was	be	AUX
dpc-4596	115	5	observed	observe	VERB
dpc-4596	115	6	between	between	ADP
dpc-4596	115	7	disease	disease	NOUN
dpc-4596	115	8	duration	duration	NOUN
dpc-4596	115	9	and	and	CCONJ
dpc-4596	115	10	both	both	DET
dpc-4596	115	11	mtorc1	mtorc1	NOUN
dpc-4596	115	12	and	and	CCONJ
dpc-4596	115	13	mtorc2	mtorc2	NOUN
dpc-4596	115	14	levels	level	NOUN
dpc-4596	115	15	(	(	PUNCT
dpc-4596	115	16	p=	p=	NOUN
dpc-4596	115	17	0.041	0.041	NUM
dpc-4596	115	18	,	,	PUNCT
dpc-4596	115	19	r=	r=	ADJ
dpc-4596	115	20	-0.320	-0.320	NOUN
dpc-4596	115	21	;	;	PUNCT
dpc-4596	115	22	p=	p=	NOUN
dpc-4596	115	23	0.046	0.046	NUM
dpc-4596	115	24	,	,	PUNCT
dpc-4596	115	25	r=	r=	PROPN
dpc-4596	115	26	-0.314	-0.314	PRON
dpc-4596	115	27	,	,	PUNCT
dpc-4596	115	28	respectively	respectively	ADV
dpc-4596	115	29	)	)	PUNCT
dpc-4596	115	30	(	(	PUNCT
dpc-4596	115	31	figures	figure	NOUN
dpc-4596	115	32	2	2	NUM
dpc-4596	115	33	,	,	PUNCT
dpc-4596	115	34	3	3	NUM
dpc-4596	115	35	)	)	PUNCT
dpc-4596	115	36	.	.	PUNCT
dpc-4596	116	1	discussion	discussion	NOUN
dpc-4596	116	2	a	a	DET
dpc-4596	116	3	significant	significant	ADJ
dpc-4596	116	4	number	number	NOUN
dpc-4596	116	5	of	of	ADP
dpc-4596	116	6	aspects	aspect	NOUN
dpc-4596	116	7	pertaining	pertain	VERB
dpc-4596	116	8	to	to	ADP
dpc-4596	116	9	the	the	DET
dpc-4596	116	10	pathophysiology	pathophysiology	NOUN
dpc-4596	116	11	of	of	ADP
dpc-4596	116	12	psoriasis	psoriasis	NOUN
dpc-4596	116	13	remain	remain	VERB
dpc-4596	116	14	to	to	PART
dpc-4596	116	15	be	be	AUX
dpc-4596	116	16	elucidated	elucidate	VERB
dpc-4596	116	17	,	,	PUNCT
dpc-4596	116	18	given	give	VERB
dpc-4596	116	19	the	the	DET
dpc-4596	116	20	intricate	intricate	ADJ
dpc-4596	116	21	interplay	interplay	NOUN
dpc-4596	116	22	between	between	ADP
dpc-4596	116	23	genetic	genetic	ADJ
dpc-4596	116	24	,	,	PUNCT
dpc-4596	116	25	environmental	environmental	ADJ
dpc-4596	116	26	and	and	CCONJ
dpc-4596	116	27	immunological	immunological	ADJ
dpc-4596	116	28	factors	factor	NOUN
dpc-4596	116	29	.	.	PUNCT
dpc-4596	117	1	intracellular	intracellular	ADJ
dpc-4596	117	2	signaling	signal	VERB
dpc-4596	117	3	pathways	pathway	NOUN
dpc-4596	117	4	play	play	VERB
dpc-4596	117	5	a	a	DET
dpc-4596	117	6	pivotal	pivotal	ADJ
dpc-4596	117	7	role	role	NOUN
dpc-4596	117	8	in	in	ADP
dpc-4596	117	9	the	the	DET
dpc-4596	117	10	pathogenesis	pathogenesis	NOUN
dpc-4596	117	11	of	of	ADP
dpc-4596	117	12	psoriasis	psoriasis	NOUN
dpc-4596	117	13	and	and	CCONJ
dpc-4596	117	14	other	other	ADJ
dpc-4596	117	15	inflammatory	inflammatory	ADJ
dpc-4596	117	16	dermatoses	dermatosis	NOUN
dpc-4596	117	17	,	,	PUNCT
dpc-4596	117	18	as	as	SCONJ
dpc-4596	117	19	numerous	numerous	ADJ
dpc-4596	117	20	critical	critical	ADJ
dpc-4596	117	21	pathogenic	pathogenic	ADJ
dpc-4596	117	22	events	event	NOUN
dpc-4596	117	23	in	in	ADP
dpc-4596	117	24	both	both	DET
dpc-4596	117	25	immune	immune	ADJ
dpc-4596	117	26	system	system	NOUN
dpc-4596	117	27	cells	cell	NOUN
dpc-4596	117	28	and	and	CCONJ
dpc-4596	117	29	skin	skin	NOUN
dpc-4596	117	30	resident	resident	ADJ
dpc-4596	117	31	cells	cell	NOUN
dpc-4596	117	32	are	be	AUX
dpc-4596	117	33	linked	link	VERB
dpc-4596	117	34	to	to	ADP
dpc-4596	117	35	dysregulation	dysregulation	NOUN
dpc-4596	117	36	of	of	ADP
dpc-4596	117	37	these	these	DET
dpc-4596	117	38	pathways	pathway	NOUN
dpc-4596	117	39	.	.	PUNCT
dpc-4596	118	1	among	among	ADP
dpc-4596	118	2	these	these	PRON
dpc-4596	118	3	,	,	PUNCT
dpc-4596	118	4	the	the	DET
dpc-4596	118	5	pi3k	pi3k	NOUN
dpc-4596	118	6	/	/	SYM
dpc-4596	118	7	akt/	akt/	PROPN
dpc-4596	118	8	mtor	mtor	NOUN
dpc-4596	118	9	,	,	PUNCT
dpc-4596	118	10	jak	jak	PROPN
dpc-4596	118	11	/	/	SYM
dpc-4596	118	12	stat	stat	PROPN
dpc-4596	118	13	,	,	PUNCT
dpc-4596	118	14	jnk	jnk	PROPN
dpc-4596	118	15	/	/	SYM
dpc-4596	118	16	mapk	mapk	NOUN
dpc-4596	118	17	,	,	PUNCT
dpc-4596	118	18	and	and	CCONJ
dpc-4596	118	19	wnt	wnt	NOUN
dpc-4596	118	20	signaling	signal	VERB
dpc-4596	118	21	pathways	pathway	NOUN
dpc-4596	118	22	are	be	AUX
dpc-4596	118	23	of	of	ADP
dpc-4596	118	24	particular	particular	ADJ
dpc-4596	118	25	importance	importance	NOUN
dpc-4596	118	26	in	in	ADP
dpc-4596	118	27	the	the	DET
dpc-4596	118	28	complex	complex	ADJ
dpc-4596	118	29	pathogenesis	pathogenesis	NOUN
dpc-4596	118	30	of	of	ADP
dpc-4596	118	31	psoriasis	psoriasis	NOUN
dpc-4596	118	32	[	[	X
dpc-4596	118	33	18	18	NUM
dpc-4596	118	34	]	]	PUNCT
dpc-4596	118	35	.	.	PUNCT
dpc-4596	119	1	the	the	DET
dpc-4596	119	2	mtor	mtor	NOUN
dpc-4596	119	3	signaling	signal	VERB
dpc-4596	119	4	pathway	pathway	NOUN
dpc-4596	119	5	plays	play	VERB
dpc-4596	119	6	a	a	DET
dpc-4596	119	7	pivotal	pivotal	ADJ
dpc-4596	119	8	role	role	NOUN
dpc-4596	119	9	,	,	PUNCT
dpc-4596	119	10	functioning	function	VERB
dpc-4596	119	11	as	as	ADP
dpc-4596	119	12	the	the	DET
dpc-4596	119	13	primary	primary	ADJ
dpc-4596	119	14	regulator	regulator	NOUN
dpc-4596	119	15	of	of	ADP
dpc-4596	119	16	cellular	cellular	ADJ
dpc-4596	119	17	metabolism	metabolism	NOUN
dpc-4596	119	18	and	and	CCONJ
dpc-4596	119	19	homeostasis	homeostasis	NOUN
dpc-4596	119	20	.	.	PUNCT
dpc-4596	120	1	previous	previous	ADJ
dpc-4596	120	2	studies	study	NOUN
dpc-4596	120	3	demonstrated	demonstrate	VERB
dpc-4596	120	4	elevated	elevated	ADJ
dpc-4596	120	5	activation	activation	NOUN
dpc-4596	120	6	of	of	ADP
dpc-4596	120	7	the	the	DET
dpc-4596	120	8	mtor	mtor	NOUN
dpc-4596	120	9	signaling	signal	VERB
dpc-4596	120	10	pathway	pathway	NOUN
dpc-4596	120	11	in	in	ADP
dpc-4596	120	12	tissue	tissue	NOUN
dpc-4596	120	13	samples	sample	NOUN
dpc-4596	120	14	from	from	ADP
dpc-4596	120	15	patients	patient	NOUN
dpc-4596	120	16	with	with	ADP
dpc-4596	120	17	psoriasis	psoriasis	NOUN
dpc-4596	120	18	,	,	PUNCT
dpc-4596	120	19	as	as	SCONJ
dpc-4596	120	20	evidenced	evidence	VERB
dpc-4596	120	21	by	by	ADP
dpc-4596	120	22	immunohistochemical	immunohistochemical	ADJ
dpc-4596	120	23	methods	method	NOUN
dpc-4596	120	24	[	[	X
dpc-4596	120	25	9	9	NUM
dpc-4596	120	26	]	]	PUNCT
dpc-4596	120	27	.	.	PUNCT
dpc-4596	121	1	despite	despite	SCONJ
dpc-4596	121	2	the	the	DET
dpc-4596	121	3	acknowledged	acknowledge	VERB
dpc-4596	121	4	significance	significance	NOUN
dpc-4596	121	5	of	of	ADP
dpc-4596	121	6	the	the	DET
dpc-4596	121	7	pi3k	pi3k	PROPN
dpc-4596	121	8	/	/	SYM
dpc-4596	121	9	akt	akt	PROPN
dpc-4596	121	10	/	/	SYM
dpc-4596	121	11	mtor	mtor	PROPN
dpc-4596	121	12	signaling	signal	VERB
dpc-4596	121	13	pathway	pathway	NOUN
dpc-4596	121	14	in	in	ADP
dpc-4596	121	15	the	the	DET
dpc-4596	121	16	etiology	etiology	NOUN
dpc-4596	121	17	of	of	ADP
dpc-4596	121	18	psoriasis	psoriasis	NOUN
dpc-4596	121	19	,	,	PUNCT
dpc-4596	121	20	there	there	PRON
dpc-4596	121	21	is	be	VERB
dpc-4596	121	22	a	a	DET
dpc-4596	121	23	paucity	paucity	NOUN
dpc-4596	121	24	of	of	ADP
dpc-4596	121	25	data	datum	NOUN
dpc-4596	121	26	concerning	concern	VERB
dpc-4596	121	27	serum	serum	NOUN
dpc-4596	121	28	mtorc1	mtorc1	NOUN
dpc-4596	121	29	and	and	CCONJ
dpc-4596	121	30	mtorc2	mtorc2	PROPN
dpc-4596	121	31	levels	level	NOUN
dpc-4596	121	32	.	.	PUNCT
dpc-4596	122	1	therefore	therefore	ADV
dpc-4596	122	2	,	,	PUNCT
dpc-4596	122	3	the	the	DET
dpc-4596	122	4	objective	objective	ADJ
dpc-4596	122	5	original	original	ADJ
dpc-4596	122	6	article	article	NOUN
dpc-4596	122	7	|	|	ADV
dpc-4596	122	8	dermatol	dermatol	ADJ
dpc-4596	122	9	pract	pract	NOUN
dpc-4596	122	10	concept	concept	NOUN
dpc-4596	122	11	.	.	PUNCT
dpc-4596	123	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	123	2	5	5	NUM
dpc-4596	123	3	figure	figure	NOUN
dpc-4596	123	4	1	1	NUM
dpc-4596	123	5	.	.	PUNCT
dpc-4596	123	6	positive	positive	ADJ
dpc-4596	123	7	correlation	correlation	NOUN
dpc-4596	123	8	of	of	ADP
dpc-4596	123	9	serum	serum	NOUN
dpc-4596	123	10	mtorc1	mtorc1	NOUN
dpc-4596	123	11	and	and	CCONJ
dpc-4596	123	12	serum	serum	PROPN
dpc-4596	123	13	mtorc2	mtorc2	PROPN
dpc-4596	123	14	levels	level	NOUN
dpc-4596	123	15	in	in	ADP
dpc-4596	123	16	patients	patient	NOUN
dpc-4596	123	17	with	with	ADP
dpc-4596	123	18	plaque	plaque	NOUN
dpc-4596	123	19	psoriasis	psoriasis	NOUN
dpc-4596	123	20	.	.	PUNCT
dpc-4596	124	1	figure	figure	NOUN
dpc-4596	124	2	2	2	NUM
dpc-4596	124	3	.	.	NOUN
dpc-4596	124	4	negative	negative	ADJ
dpc-4596	124	5	correlation	correlation	NOUN
dpc-4596	124	6	between	between	ADP
dpc-4596	124	7	serum	serum	NOUN
dpc-4596	124	8	mtorc1	mtorc1	NOUN
dpc-4596	124	9	levels	level	NOUN
dpc-4596	124	10	and	and	CCONJ
dpc-4596	124	11	duration	duration	NOUN
dpc-4596	124	12	of	of	ADP
dpc-4596	124	13	the	the	DET
dpc-4596	124	14	disease	disease	NOUN
dpc-4596	124	15	in	in	ADP
dpc-4596	124	16	patients	patient	NOUN
dpc-4596	124	17	with	with	ADP
dpc-4596	124	18	plaque	plaque	NOUN
dpc-4596	124	19	psoriasis	psoriasis	NOUN
dpc-4596	124	20	(	(	PUNCT
dpc-4596	124	21	p=	p=	NOUN
dpc-4596	124	22	0.041	0.041	NUM
dpc-4596	124	23	,	,	PUNCT
dpc-4596	124	24	r=	r=	ADJ
dpc-4596	124	25	-0.320	-0.320	NOUN
dpc-4596	124	26	)	)	PUNCT
dpc-4596	124	27	.	.	PUNCT
dpc-4596	125	1	6	6	NUM
dpc-4596	125	2	original	original	ADJ
dpc-4596	125	3	article	article	NOUN
dpc-4596	125	4	|	|	ADV
dpc-4596	125	5	dermatol	dermatol	ADJ
dpc-4596	125	6	pract	pract	NOUN
dpc-4596	125	7	concept	concept	NOUN
dpc-4596	125	8	.	.	PUNCT
dpc-4596	126	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	126	2	the	the	DET
dpc-4596	126	3	cell	cell	NOUN
dpc-4596	126	4	.	.	PUNCT
dpc-4596	127	1	this	this	PRON
dpc-4596	127	2	suggests	suggest	VERB
dpc-4596	127	3	that	that	SCONJ
dpc-4596	127	4	the	the	DET
dpc-4596	127	5	levels	level	NOUN
dpc-4596	127	6	of	of	ADP
dpc-4596	127	7	effector	effector	NOUN
dpc-4596	127	8	proteins	protein	NOUN
dpc-4596	127	9	involved	involve	VERB
dpc-4596	127	10	in	in	ADP
dpc-4596	127	11	the	the	DET
dpc-4596	127	12	mtor	mtor	PROPN
dpc-4596	127	13	pathway	pathway	NOUN
dpc-4596	127	14	in	in	ADP
dpc-4596	127	15	serum	serum	NOUN
dpc-4596	127	16	may	may	AUX
dpc-4596	127	17	differ	differ	VERB
dpc-4596	127	18	from	from	ADP
dpc-4596	127	19	those	those	PRON
dpc-4596	127	20	in	in	ADP
dpc-4596	127	21	tissue	tissue	NOUN
dpc-4596	127	22	.	.	PUNCT
dpc-4596	128	1	secondly	secondly	ADV
dpc-4596	128	2	,	,	PUNCT
dpc-4596	128	3	it	it	PRON
dpc-4596	128	4	is	be	AUX
dpc-4596	128	5	possible	possible	ADJ
dpc-4596	128	6	that	that	SCONJ
dpc-4596	128	7	additional	additional	ADJ
dpc-4596	128	8	mechanisms	mechanism	NOUN
dpc-4596	128	9	may	may	AUX
dpc-4596	128	10	be	be	AUX
dpc-4596	128	11	involved	involve	VERB
dpc-4596	128	12	in	in	ADP
dpc-4596	128	13	the	the	DET
dpc-4596	128	14	activation	activation	NOUN
dpc-4596	128	15	of	of	ADP
dpc-4596	128	16	the	the	DET
dpc-4596	128	17	mtor	mtor	PROPN
dpc-4596	128	18	pathway	pathway	NOUN
dpc-4596	128	19	in	in	ADP
dpc-4596	128	20	psoriatic	psoriatic	ADJ
dpc-4596	128	21	tissue	tissue	NOUN
dpc-4596	128	22	.	.	PUNCT
dpc-4596	129	1	however	however	ADV
dpc-4596	129	2	,	,	PUNCT
dpc-4596	129	3	the	the	DET
dpc-4596	129	4	precise	precise	ADJ
dpc-4596	129	5	cause	cause	NOUN
dpc-4596	129	6	of	of	ADP
dpc-4596	129	7	this	this	DET
dpc-4596	129	8	discrepancy	discrepancy	NOUN
dpc-4596	129	9	remains	remain	VERB
dpc-4596	129	10	unclear	unclear	ADJ
dpc-4596	129	11	.	.	PUNCT
dpc-4596	130	1	consequently	consequently	ADV
dpc-4596	130	2	,	,	PUNCT
dpc-4596	130	3	further	further	ADJ
dpc-4596	130	4	investigation	investigation	NOUN
dpc-4596	130	5	is	be	AUX
dpc-4596	130	6	required	require	VERB
dpc-4596	130	7	to	to	PART
dpc-4596	130	8	elucidate	elucidate	VERB
dpc-4596	130	9	the	the	DET
dpc-4596	130	10	underlying	underlie	VERB
dpc-4596	130	11	mechanisms	mechanism	NOUN
dpc-4596	130	12	.	.	PUNCT
dpc-4596	131	1	to	to	PART
dpc-4596	131	2	ascertain	ascertain	VERB
dpc-4596	131	3	whether	whether	SCONJ
dpc-4596	131	4	there	there	PRON
dpc-4596	131	5	is	be	VERB
dpc-4596	131	6	a	a	DET
dpc-4596	131	7	correlation	correlation	NOUN
dpc-4596	131	8	between	between	ADP
dpc-4596	131	9	psoriasis	psoriasis	NOUN
dpc-4596	131	10	disease	disease	NOUN
dpc-4596	131	11	severity	severity	NOUN
dpc-4596	131	12	and	and	CCONJ
dpc-4596	131	13	serum	serum	NOUN
dpc-4596	131	14	mtorc1	mtorc1	NOUN
dpc-4596	131	15	and	and	CCONJ
dpc-4596	131	16	mtorc2	mtorc2	PROPN
dpc-4596	131	17	levels	level	NOUN
dpc-4596	131	18	,	,	PUNCT
dpc-4596	131	19	the	the	DET
dpc-4596	131	20	patient	patient	ADJ
dpc-4596	131	21	cohort	cohort	NOUN
dpc-4596	131	22	was	be	AUX
dpc-4596	131	23	stratified	stratify	VERB
dpc-4596	131	24	into	into	ADP
dpc-4596	131	25	two	two	NUM
dpc-4596	131	26	subgroups	subgroup	NOUN
dpc-4596	131	27	,	,	PUNCT
dpc-4596	131	28	designated	designate	VERB
dpc-4596	131	29	as	as	ADP
dpc-4596	131	30	mild	mild	ADJ
dpc-4596	131	31	and	and	CCONJ
dpc-4596	131	32	moderate	moderate	ADJ
dpc-4596	131	33	-	-	PUNCT
dpc-4596	131	34	to	to	ADP
dpc-4596	131	35	-	-	PUNCT
dpc-4596	131	36	severe	severe	ADJ
dpc-4596	131	37	,	,	PUNCT
dpc-4596	131	38	based	base	VERB
dpc-4596	131	39	on	on	ADP
dpc-4596	131	40	their	their	PRON
dpc-4596	131	41	pasi	pasi	NOUN
dpc-4596	131	42	scores	score	NOUN
dpc-4596	131	43	.	.	PUNCT
dpc-4596	132	1	no	no	DET
dpc-4596	132	2	statistically	statistically	ADV
dpc-4596	132	3	significant	significant	ADJ
dpc-4596	132	4	difference	difference	NOUN
dpc-4596	132	5	was	be	AUX
dpc-4596	132	6	observed	observe	VERB
dpc-4596	132	7	between	between	ADP
dpc-4596	132	8	the	the	DET
dpc-4596	132	9	two	two	NUM
dpc-4596	132	10	groups	group	NOUN
dpc-4596	132	11	.	.	PUNCT
dpc-4596	133	1	this	this	DET
dpc-4596	133	2	discrepancy	discrepancy	NOUN
dpc-4596	133	3	is	be	AUX
dpc-4596	133	4	likely	likely	ADJ
dpc-4596	133	5	due	due	ADP
dpc-4596	133	6	to	to	ADP
dpc-4596	133	7	the	the	DET
dpc-4596	133	8	limited	limited	ADJ
dpc-4596	133	9	number	number	NOUN
dpc-4596	133	10	of	of	ADP
dpc-4596	133	11	cases	case	NOUN
dpc-4596	133	12	with	with	ADP
dpc-4596	133	13	moderate	moderate	ADJ
dpc-4596	133	14	-	-	PUNCT
dpc-4596	133	15	to	to	ADP
dpc-4596	133	16	-	-	PUNCT
dpc-4596	133	17	severe	severe	ADJ
dpc-4596	133	18	psoriasis	psoriasis	NOUN
dpc-4596	133	19	included	include	VERB
dpc-4596	133	20	in	in	ADP
dpc-4596	133	21	the	the	DET
dpc-4596	133	22	study	study	NOUN
dpc-4596	133	23	.	.	PUNCT
dpc-4596	134	1	however	however	ADV
dpc-4596	134	2	,	,	PUNCT
dpc-4596	134	3	a	a	DET
dpc-4596	134	4	negative	negative	ADJ
dpc-4596	134	5	correlation	correlation	NOUN
dpc-4596	134	6	was	be	AUX
dpc-4596	134	7	identified	identify	VERB
dpc-4596	134	8	between	between	ADP
dpc-4596	134	9	serum	serum	NOUN
dpc-4596	134	10	levels	level	NOUN
dpc-4596	134	11	of	of	ADP
dpc-4596	134	12	both	both	DET
dpc-4596	134	13	mtorc1	mtorc1	NOUN
dpc-4596	134	14	and	and	CCONJ
dpc-4596	134	15	mtorc2	mtorc2	NOUN
dpc-4596	134	16	and	and	CCONJ
dpc-4596	134	17	disease	disease	NOUN
dpc-4596	134	18	duration	duration	NOUN
dpc-4596	134	19	in	in	ADP
dpc-4596	134	20	patients	patient	NOUN
dpc-4596	134	21	with	with	ADP
dpc-4596	134	22	psoriasis	psoriasis	NOUN
dpc-4596	134	23	,	,	PUNCT
dpc-4596	134	24	with	with	ADP
dpc-4596	134	25	a	a	DET
dpc-4596	134	26	statistically	statistically	ADV
dpc-4596	134	27	significant	significant	ADJ
dpc-4596	134	28	result	result	NOUN
dpc-4596	134	29	.	.	PUNCT
dpc-4596	135	1	the	the	DET
dpc-4596	135	2	observed	observe	VERB
dpc-4596	135	3	reduction	reduction	NOUN
dpc-4596	135	4	in	in	ADP
dpc-4596	135	5	serum	serum	NOUN
dpc-4596	135	6	mtorc1	mtorc1	NOUN
dpc-4596	135	7	and	and	CCONJ
dpc-4596	135	8	mtorc2	mtorc2	NOUN
dpc-4596	135	9	levels	level	NOUN
dpc-4596	135	10	in	in	ADP
dpc-4596	135	11	individuals	individual	NOUN
dpc-4596	135	12	with	with	ADP
dpc-4596	135	13	active	active	ADJ
dpc-4596	135	14	disease	disease	NOUN
dpc-4596	135	15	and	and	CCONJ
dpc-4596	135	16	prolonged	prolonged	ADJ
dpc-4596	135	17	disease	disease	NOUN
dpc-4596	135	18	duration	duration	NOUN
dpc-4596	135	19	may	may	AUX
dpc-4596	135	20	indicate	indicate	VERB
dpc-4596	135	21	a	a	DET
dpc-4596	135	22	role	role	NOUN
dpc-4596	135	23	for	for	ADP
dpc-4596	135	24	these	these	DET
dpc-4596	135	25	factors	factor	NOUN
dpc-4596	135	26	in	in	ADP
dpc-4596	135	27	the	the	DET
dpc-4596	135	28	perpetuation	perpetuation	NOUN
dpc-4596	135	29	of	of	ADP
dpc-4596	135	30	the	the	DET
dpc-4596	135	31	chronic	chronic	ADJ
dpc-4596	135	32	inflammatory	inflammatory	ADJ
dpc-4596	135	33	process	process	NOUN
dpc-4596	135	34	.	.	PUNCT
dpc-4596	136	1	mtorc1	mtorc1	NOUN
dpc-4596	136	2	is	be	AUX
dpc-4596	136	3	sensitive	sensitive	ADJ
dpc-4596	136	4	to	to	ADP
dpc-4596	136	5	rapamycin	rapamycin	NOUN
dpc-4596	136	6	,	,	PUNCT
dpc-4596	136	7	while	while	SCONJ
dpc-4596	136	8	mtorc2	mtorc2	PROPN
dpc-4596	136	9	has	have	AUX
dpc-4596	136	10	been	be	AUX
dpc-4596	136	11	demonstrated	demonstrate	VERB
dpc-4596	136	12	to	to	PART
dpc-4596	136	13	be	be	AUX
dpc-4596	136	14	inhibited	inhibit	VERB
dpc-4596	136	15	in	in	ADP
dpc-4596	136	16	certain	certain	ADJ
dpc-4596	136	17	cell	cell	NOUN
dpc-4596	136	18	types	type	NOUN
dpc-4596	136	19	by	by	ADP
dpc-4596	136	20	long	long	ADJ
dpc-4596	136	21	-	-	PUNCT
dpc-4596	136	22	term	term	NOUN
dpc-4596	136	23	sirolimus	sirolimus	NOUN
dpc-4596	136	24	treatment	treatment	NOUN
dpc-4596	136	25	[	[	X
dpc-4596	136	26	20	20	NUM
dpc-4596	136	27	]	]	PUNCT
dpc-4596	136	28	.	.	PUNCT
dpc-4596	137	1	it	it	PRON
dpc-4596	137	2	has	have	AUX
dpc-4596	137	3	been	be	AUX
dpc-4596	137	4	proposed	propose	VERB
dpc-4596	137	5	of	of	ADP
dpc-4596	137	6	this	this	DET
dpc-4596	137	7	study	study	NOUN
dpc-4596	137	8	was	be	AUX
dpc-4596	137	9	to	to	PART
dpc-4596	137	10	examine	examine	VERB
dpc-4596	137	11	the	the	DET
dpc-4596	137	12	serum	serum	NOUN
dpc-4596	137	13	levels	level	NOUN
dpc-4596	137	14	of	of	ADP
dpc-4596	137	15	mtorc1	mtorc1	NOUN
dpc-4596	137	16	and	and	CCONJ
dpc-4596	137	17	mtorc2	mtorc2	NOUN
dpc-4596	137	18	complexes	complexe	VERB
dpc-4596	137	19	in	in	ADP
dpc-4596	137	20	a	a	DET
dpc-4596	137	21	cohort	cohort	NOUN
dpc-4596	137	22	of	of	ADP
dpc-4596	137	23	40	40	NUM
dpc-4596	137	24	patients	patient	NOUN
dpc-4596	137	25	with	with	ADP
dpc-4596	137	26	plaque	plaque	NOUN
dpc-4596	137	27	psoriasis	psoriasis	NOUN
dpc-4596	137	28	and	and	CCONJ
dpc-4596	137	29	to	to	PART
dpc-4596	137	30	compare	compare	VERB
dpc-4596	137	31	these	these	DET
dpc-4596	137	32	levels	level	NOUN
dpc-4596	137	33	with	with	ADP
dpc-4596	137	34	those	those	PRON
dpc-4596	137	35	observed	observe	VERB
dpc-4596	137	36	in	in	ADP
dpc-4596	137	37	a	a	DET
dpc-4596	137	38	control	control	NOUN
dpc-4596	137	39	group	group	NOUN
dpc-4596	137	40	of	of	ADP
dpc-4596	137	41	40	40	NUM
dpc-4596	137	42	non	non	ADJ
dpc-4596	137	43	-	-	ADJ
dpc-4596	137	44	psoriatic	psoriatic	ADJ
dpc-4596	137	45	individuals	individual	NOUN
dpc-4596	137	46	.	.	PUNCT
dpc-4596	138	1	this	this	DET
dpc-4596	138	2	study	study	NOUN
dpc-4596	138	3	demonstrated	demonstrate	VERB
dpc-4596	138	4	that	that	SCONJ
dpc-4596	138	5	serum	serum	NOUN
dpc-4596	138	6	mtorc1	mtorc1	NOUN
dpc-4596	138	7	and	and	CCONJ
dpc-4596	138	8	mtorc2	mtorc2	NOUN
dpc-4596	138	9	levels	level	NOUN
dpc-4596	138	10	were	be	AUX
dpc-4596	138	11	significantly	significantly	ADV
dpc-4596	138	12	lower	low	ADJ
dpc-4596	138	13	in	in	ADP
dpc-4596	138	14	patients	patient	NOUN
dpc-4596	138	15	with	with	ADP
dpc-4596	138	16	plaque	plaque	NOUN
dpc-4596	138	17	psoriasis	psoriasis	NOUN
dpc-4596	138	18	compared	compare	VERB
dpc-4596	138	19	to	to	AUX
dpc-4596	138	20	control	control	VERB
dpc-4596	138	21	subjects	subject	NOUN
dpc-4596	138	22	.	.	PUNCT
dpc-4596	139	1	another	another	DET
dpc-4596	139	2	study	study	NOUN
dpc-4596	139	3	,	,	PUNCT
dpc-4596	139	4	conducted	conduct	VERB
dpc-4596	139	5	by	by	ADP
dpc-4596	139	6	cheng	cheng	PROPN
dpc-4596	139	7	et	et	PROPN
dpc-4596	139	8	al	al	PROPN
dpc-4596	139	9	.	.	PROPN
dpc-4596	139	10	,	,	PUNCT
dpc-4596	139	11	employed	employ	VERB
dpc-4596	139	12	the	the	DET
dpc-4596	139	13	elisa	elisa	NOUN
dpc-4596	139	14	method	method	NOUN
dpc-4596	139	15	to	to	PART
dpc-4596	139	16	investigate	investigate	VERB
dpc-4596	139	17	the	the	DET
dpc-4596	139	18	serum	serum	NOUN
dpc-4596	139	19	levels	level	NOUN
dpc-4596	139	20	of	of	ADP
dpc-4596	139	21	mtor	mtor	NOUN
dpc-4596	139	22	and	and	CCONJ
dpc-4596	139	23	ps6k	ps6k	NOUN
dpc-4596	139	24	in	in	ADP
dpc-4596	139	25	order	order	NOUN
dpc-4596	139	26	to	to	PART
dpc-4596	139	27	elucidate	elucidate	VERB
dpc-4596	139	28	the	the	DET
dpc-4596	139	29	role	role	NOUN
dpc-4596	139	30	of	of	ADP
dpc-4596	139	31	the	the	DET
dpc-4596	139	32	mtor	mtor	PROPN
dpc-4596	139	33	pathway	pathway	NOUN
dpc-4596	139	34	in	in	ADP
dpc-4596	139	35	sepsis	sepsis	NOUN
dpc-4596	139	36	-	-	PUNCT
dpc-4596	139	37	associated	associate	VERB
dpc-4596	139	38	myocardial	myocardial	ADJ
dpc-4596	139	39	dysfunction	dysfunction	NOUN
dpc-4596	139	40	(	(	PUNCT
dpc-4596	139	41	simd	simd	PROPN
dpc-4596	139	42	)	)	PUNCT
dpc-4596	140	1	[	[	X
dpc-4596	140	2	19	19	NUM
dpc-4596	140	3	]	]	PUNCT
dpc-4596	140	4	.	.	PUNCT
dpc-4596	141	1	the	the	DET
dpc-4596	141	2	researchers	researcher	NOUN
dpc-4596	141	3	observed	observe	VERB
dpc-4596	141	4	that	that	SCONJ
dpc-4596	141	5	the	the	DET
dpc-4596	141	6	serum	serum	NOUN
dpc-4596	141	7	mtor	mtor	PROPN
dpc-4596	141	8	levels	level	NOUN
dpc-4596	141	9	in	in	ADP
dpc-4596	141	10	the	the	DET
dpc-4596	141	11	patient	patient	ADJ
dpc-4596	141	12	group	group	NOUN
dpc-4596	141	13	with	with	ADP
dpc-4596	141	14	simd	simd	PROPN
dpc-4596	141	15	were	be	AUX
dpc-4596	141	16	lower	low	ADJ
dpc-4596	141	17	than	than	ADP
dpc-4596	141	18	those	those	PRON
dpc-4596	141	19	in	in	ADP
dpc-4596	141	20	the	the	DET
dpc-4596	141	21	control	control	NOUN
dpc-4596	141	22	group	group	NOUN
dpc-4596	141	23	,	,	PUNCT
dpc-4596	141	24	but	but	CCONJ
dpc-4596	141	25	this	this	DET
dpc-4596	141	26	difference	difference	NOUN
dpc-4596	141	27	was	be	AUX
dpc-4596	141	28	not	not	PART
dpc-4596	141	29	statistically	statistically	ADV
dpc-4596	141	30	significant	significant	ADJ
dpc-4596	141	31	.	.	PUNCT
dpc-4596	142	1	conversely	conversely	ADV
dpc-4596	142	2	,	,	PUNCT
dpc-4596	142	3	the	the	DET
dpc-4596	142	4	ps6k	ps6k	NOUN
dpc-4596	142	5	level	level	NOUN
dpc-4596	142	6	,	,	PUNCT
dpc-4596	142	7	which	which	PRON
dpc-4596	142	8	is	be	AUX
dpc-4596	142	9	one	one	NUM
dpc-4596	142	10	of	of	ADP
dpc-4596	142	11	the	the	DET
dpc-4596	142	12	substrates	substrate	NOUN
dpc-4596	142	13	of	of	ADP
dpc-4596	142	14	mtorc1	mtorc1	NOUN
dpc-4596	142	15	,	,	PUNCT
dpc-4596	142	16	was	be	AUX
dpc-4596	142	17	found	find	VERB
dpc-4596	142	18	to	to	PART
dpc-4596	142	19	be	be	AUX
dpc-4596	142	20	higher	high	ADJ
dpc-4596	142	21	in	in	ADP
dpc-4596	142	22	the	the	DET
dpc-4596	142	23	patient	patient	NOUN
dpc-4596	142	24	group	group	NOUN
dpc-4596	142	25	with	with	ADP
dpc-4596	142	26	simd	simd	PROPN
dpc-4596	142	27	,	,	PUNCT
dpc-4596	142	28	and	and	CCONJ
dpc-4596	142	29	this	this	DET
dpc-4596	142	30	difference	difference	NOUN
dpc-4596	142	31	was	be	AUX
dpc-4596	142	32	statistically	statistically	ADV
dpc-4596	142	33	significant	significant	ADJ
dpc-4596	142	34	.	.	PUNCT
dpc-4596	143	1	similarly	similarly	ADV
dpc-4596	143	2	,	,	PUNCT
dpc-4596	143	3	our	our	PRON
dpc-4596	143	4	study	study	NOUN
dpc-4596	143	5	revealed	reveal	VERB
dpc-4596	143	6	low	low	ADJ
dpc-4596	143	7	levels	level	NOUN
dpc-4596	143	8	of	of	ADP
dpc-4596	143	9	mtorc1	mtorc1	NOUN
dpc-4596	143	10	and	and	CCONJ
dpc-4596	143	11	mtorc2	mtorc2	PROPN
dpc-4596	143	12	in	in	ADP
dpc-4596	143	13	the	the	DET
dpc-4596	143	14	serum	serum	NOUN
dpc-4596	143	15	of	of	ADP
dpc-4596	143	16	patients	patient	NOUN
dpc-4596	143	17	with	with	ADP
dpc-4596	143	18	plaque	plaque	NOUN
dpc-4596	143	19	psoriasis	psoriasis	NOUN
dpc-4596	143	20	.	.	PUNCT
dpc-4596	144	1	nevertheless	nevertheless	ADV
dpc-4596	144	2	,	,	PUNCT
dpc-4596	144	3	it	it	PRON
dpc-4596	144	4	is	be	AUX
dpc-4596	144	5	established	establish	VERB
dpc-4596	144	6	in	in	ADP
dpc-4596	144	7	the	the	DET
dpc-4596	144	8	literature	literature	NOUN
dpc-4596	144	9	that	that	PRON
dpc-4596	144	10	the	the	DET
dpc-4596	144	11	activation	activation	NOUN
dpc-4596	144	12	of	of	ADP
dpc-4596	144	13	mtor	mtor	NOUN
dpc-4596	144	14	increases	increase	NOUN
dpc-4596	144	15	in	in	ADP
dpc-4596	144	16	psoriatic	psoriatic	ADJ
dpc-4596	144	17	tissue	tissue	NOUN
dpc-4596	144	18	.	.	PUNCT
dpc-4596	145	1	the	the	DET
dpc-4596	145	2	following	follow	VERB
dpc-4596	145	3	explanations	explanation	NOUN
dpc-4596	145	4	may	may	AUX
dpc-4596	145	5	be	be	AUX
dpc-4596	145	6	put	put	VERB
dpc-4596	145	7	forward	forward	ADV
dpc-4596	145	8	to	to	PART
dpc-4596	145	9	account	account	VERB
dpc-4596	145	10	for	for	ADP
dpc-4596	145	11	this	this	DET
dpc-4596	145	12	discrepancy	discrepancy	NOUN
dpc-4596	145	13	.	.	PUNCT
dpc-4596	146	1	firstly	firstly	ADV
dpc-4596	146	2	,	,	PUNCT
dpc-4596	146	3	it	it	PRON
dpc-4596	146	4	should	should	AUX
dpc-4596	146	5	be	be	AUX
dpc-4596	146	6	noted	note	VERB
dpc-4596	146	7	that	that	SCONJ
dpc-4596	146	8	the	the	DET
dpc-4596	146	9	elisa	elisa	NOUN
dpc-4596	146	10	method	method	NOUN
dpc-4596	146	11	utilized	utilize	VERB
dpc-4596	146	12	in	in	ADP
dpc-4596	146	13	this	this	DET
dpc-4596	146	14	study	study	NOUN
dpc-4596	146	15	measures	measure	VERB
dpc-4596	146	16	the	the	DET
dpc-4596	146	17	total	total	ADJ
dpc-4596	146	18	mtor	mtor	NOUN
dpc-4596	146	19	concentration	concentration	NOUN
dpc-4596	146	20	in	in	ADP
dpc-4596	146	21	serum	serum	NOUN
dpc-4596	146	22	,	,	PUNCT
dpc-4596	146	23	whereas	whereas	SCONJ
dpc-4596	146	24	the	the	DET
dpc-4596	146	25	main	main	ADJ
dpc-4596	146	26	active	active	ADJ
dpc-4596	146	27	state	state	NOUN
dpc-4596	146	28	of	of	ADP
dpc-4596	146	29	mtor	mtor	PROPN
dpc-4596	146	30	is	be	AUX
dpc-4596	146	31	in	in	ADP
dpc-4596	146	32	the	the	DET
dpc-4596	146	33	phosphorylated	phosphorylate	VERB
dpc-4596	146	34	form	form	NOUN
dpc-4596	146	35	within	within	ADP
dpc-4596	146	36	figure	figure	NOUN
dpc-4596	146	37	3	3	NUM
dpc-4596	146	38	.	.	NOUN
dpc-4596	146	39	negative	negative	ADJ
dpc-4596	146	40	correlation	correlation	NOUN
dpc-4596	146	41	between	between	ADP
dpc-4596	146	42	serum	serum	PROPN
dpc-4596	146	43	mtorc2	mtorc2	PROPN
dpc-4596	146	44	levels	level	NOUN
dpc-4596	146	45	and	and	CCONJ
dpc-4596	146	46	duration	duration	NOUN
dpc-4596	146	47	of	of	ADP
dpc-4596	146	48	the	the	DET
dpc-4596	146	49	disease	disease	NOUN
dpc-4596	146	50	in	in	ADP
dpc-4596	146	51	patients	patient	NOUN
dpc-4596	146	52	with	with	ADP
dpc-4596	146	53	plaque	plaque	NOUN
dpc-4596	146	54	psoriasis	psoriasis	NOUN
dpc-4596	146	55	(	(	PUNCT
dpc-4596	146	56	p=	p=	NOUN
dpc-4596	146	57	0.046	0.046	NUM
dpc-4596	146	58	,	,	PUNCT
dpc-4596	146	59	r=	r=	ADJ
dpc-4596	146	60	-0.314	-0.314	NUM
dpc-4596	146	61	)	)	PUNCT
dpc-4596	146	62	.	.	PUNCT
dpc-4596	147	1	original	original	ADJ
dpc-4596	147	2	article	article	NOUN
dpc-4596	147	3	|	|	ADV
dpc-4596	147	4	dermatol	dermatol	ADJ
dpc-4596	147	5	pract	pract	NOUN
dpc-4596	147	6	concept	concept	NOUN
dpc-4596	147	7	.	.	PUNCT
dpc-4596	148	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	148	2	7	7	NUM
dpc-4596	148	3	more	more	ADV
dpc-4596	148	4	comprehensive	comprehensive	ADJ
dpc-4596	148	5	understanding	understanding	NOUN
dpc-4596	148	6	of	of	ADP
dpc-4596	148	7	the	the	DET
dpc-4596	148	8	role	role	NOUN
dpc-4596	148	9	of	of	ADP
dpc-4596	148	10	the	the	DET
dpc-4596	148	11	mtor	mtor	PROPN
dpc-4596	148	12	pathway	pathway	NOUN
dpc-4596	148	13	and	and	CCONJ
dpc-4596	148	14	its	its	PRON
dpc-4596	148	15	relationship	relationship	NOUN
dpc-4596	148	16	to	to	ADP
dpc-4596	148	17	variables	variable	NOUN
dpc-4596	148	18	in	in	ADP
dpc-4596	148	19	patients	patient	NOUN
dpc-4596	148	20	,	,	PUNCT
dpc-4596	148	21	such	such	ADJ
dpc-4596	148	22	as	as	ADP
dpc-4596	148	23	disease	disease	NOUN
dpc-4596	148	24	severity	severity	NOUN
dpc-4596	148	25	and	and	CCONJ
dpc-4596	148	26	comorbidities	comorbiditie	NOUN
dpc-4596	148	27	,	,	PUNCT
dpc-4596	148	28	further	further	ADJ
dpc-4596	148	29	studies	study	NOUN
dpc-4596	148	30	with	with	ADP
dpc-4596	148	31	larger	large	ADJ
dpc-4596	148	32	numbers	number	NOUN
dpc-4596	148	33	of	of	ADP
dpc-4596	148	34	patients	patient	NOUN
dpc-4596	148	35	are	be	AUX
dpc-4596	148	36	required	require	VERB
dpc-4596	148	37	.	.	PUNCT
dpc-4596	149	1	conclusion	conclusion	NOUN
dpc-4596	149	2	in	in	ADP
dpc-4596	149	3	conclusion	conclusion	NOUN
dpc-4596	149	4	,	,	PUNCT
dpc-4596	149	5	we	we	PRON
dpc-4596	149	6	found	find	VERB
dpc-4596	149	7	that	that	SCONJ
dpc-4596	149	8	the	the	DET
dpc-4596	149	9	serum	serum	NOUN
dpc-4596	149	10	mtorc1	mtorc1	NOUN
dpc-4596	149	11	and	and	CCONJ
dpc-4596	149	12	mtorc2	mtorc2	NOUN
dpc-4596	149	13	levels	level	NOUN
dpc-4596	149	14	of	of	ADP
dpc-4596	149	15	patients	patient	NOUN
dpc-4596	149	16	with	with	ADP
dpc-4596	149	17	plaque	plaque	NOUN
dpc-4596	149	18	psoriasis	psoriasis	NOUN
dpc-4596	149	19	were	be	AUX
dpc-4596	149	20	lower	low	ADJ
dpc-4596	149	21	than	than	ADP
dpc-4596	149	22	those	those	PRON
dpc-4596	149	23	of	of	ADP
dpc-4596	149	24	control	control	NOUN
dpc-4596	149	25	subjects	subject	NOUN
dpc-4596	149	26	.	.	PUNCT
dpc-4596	150	1	this	this	PRON
dpc-4596	150	2	can	can	AUX
dpc-4596	150	3	be	be	AUX
dpc-4596	150	4	explained	explain	VERB
dpc-4596	150	5	by	by	ADP
dpc-4596	150	6	the	the	DET
dpc-4596	150	7	fact	fact	NOUN
dpc-4596	150	8	that	that	SCONJ
dpc-4596	150	9	mtorc1	mtorc1	NOUN
dpc-4596	150	10	and	and	CCONJ
dpc-4596	150	11	mtorc2	mtorc2	NOUN
dpc-4596	150	12	complexes	complex	NOUN
dpc-4596	150	13	,	,	PUNCT
dpc-4596	150	14	which	which	PRON
dpc-4596	150	15	belong	belong	VERB
dpc-4596	150	16	to	to	ADP
dpc-4596	150	17	the	the	DET
dpc-4596	150	18	mtor	mtor	NOUN
dpc-4596	150	19	signaling	signal	VERB
dpc-4596	150	20	pathway	pathway	NOUN
dpc-4596	150	21	,	,	PUNCT
dpc-4596	150	22	are	be	AUX
dpc-4596	150	23	active	active	ADJ
dpc-4596	150	24	molecules	molecule	NOUN
dpc-4596	150	25	within	within	ADP
dpc-4596	150	26	the	the	DET
dpc-4596	150	27	cell	cell	NOUN
dpc-4596	150	28	.	.	PUNCT
dpc-4596	151	1	to	to	PART
dpc-4596	151	2	further	far	ADV
dpc-4596	151	3	evaluate	evaluate	VERB
dpc-4596	151	4	these	these	DET
dpc-4596	151	5	results	result	NOUN
dpc-4596	151	6	,	,	PUNCT
dpc-4596	151	7	it	it	PRON
dpc-4596	151	8	would	would	AUX
dpc-4596	151	9	be	be	AUX
dpc-4596	151	10	beneficial	beneficial	ADJ
dpc-4596	151	11	to	to	PART
dpc-4596	151	12	conduct	conduct	VERB
dpc-4596	151	13	comparative	comparative	ADJ
dpc-4596	151	14	studies	study	NOUN
dpc-4596	151	15	of	of	ADP
dpc-4596	151	16	the	the	DET
dpc-4596	151	17	activity	activity	NOUN
dpc-4596	151	18	of	of	ADP
dpc-4596	151	19	the	the	DET
dpc-4596	151	20	mtor	mtor	PROPN
dpc-4596	151	21	pathway	pathway	NOUN
dpc-4596	151	22	in	in	ADP
dpc-4596	151	23	tissue	tissue	NOUN
dpc-4596	151	24	and	and	CCONJ
dpc-4596	151	25	serum	serum	NOUN
dpc-4596	151	26	.	.	PUNCT
dpc-4596	152	1	the	the	DET
dpc-4596	152	2	observed	observe	VERB
dpc-4596	152	3	positive	positive	ADJ
dpc-4596	152	4	correlation	correlation	NOUN
dpc-4596	152	5	between	between	ADP
dpc-4596	152	6	serum	serum	NOUN
dpc-4596	152	7	mtorc1	mtorc1	NOUN
dpc-4596	152	8	and	and	CCONJ
dpc-4596	152	9	serum	serum	PROPN
dpc-4596	152	10	mtorc2	mtorc2	PROPN
dpc-4596	152	11	levels	level	NOUN
dpc-4596	152	12	in	in	ADP
dpc-4596	152	13	the	the	DET
dpc-4596	152	14	patient	patient	NOUN
dpc-4596	152	15	group	group	NOUN
dpc-4596	152	16	provides	provide	VERB
dpc-4596	152	17	evidence	evidence	NOUN
dpc-4596	152	18	that	that	SCONJ
dpc-4596	152	19	both	both	PRON
dpc-4596	152	20	mtorc1	mtorc1	NOUN
dpc-4596	152	21	and	and	CCONJ
dpc-4596	152	22	mtorc2	mtorc2	NOUN
dpc-4596	152	23	complexes	complex	NOUN
dpc-4596	152	24	play	play	VERB
dpc-4596	152	25	an	an	DET
dpc-4596	152	26	important	important	ADJ
dpc-4596	152	27	role	role	NOUN
dpc-4596	152	28	in	in	ADP
dpc-4596	152	29	the	the	DET
dpc-4596	152	30	pathogenesis	pathogenesis	NOUN
dpc-4596	152	31	of	of	ADP
dpc-4596	152	32	psoriasis	psoriasis	NOUN
dpc-4596	152	33	.	.	PUNCT
dpc-4596	153	1	consequently	consequently	ADV
dpc-4596	153	2	,	,	PUNCT
dpc-4596	153	3	molecules	molecule	NOUN
dpc-4596	153	4	that	that	PRON
dpc-4596	153	5	inhibit	inhibit	VERB
dpc-4596	153	6	both	both	DET
dpc-4596	153	7	complexes	complex	NOUN
dpc-4596	153	8	may	may	AUX
dpc-4596	153	9	prove	prove	VERB
dpc-4596	153	10	to	to	PART
dpc-4596	153	11	be	be	AUX
dpc-4596	153	12	more	more	ADV
dpc-4596	153	13	effective	effective	ADJ
dpc-4596	153	14	in	in	ADP
dpc-4596	153	15	the	the	DET
dpc-4596	153	16	treatment	treatment	NOUN
dpc-4596	153	17	of	of	ADP
dpc-4596	153	18	psoriasis	psoriasis	NOUN
dpc-4596	153	19	.	.	PUNCT
dpc-4596	154	1	abbreviations	abbreviation	NOUN
dpc-4596	154	2	:	:	PUNCT
dpc-4596	154	3	mtor	mtor	NOUN
dpc-4596	154	4	:	:	PUNCT
dpc-4596	154	5	mammalian	mammalian	ADJ
dpc-4596	154	6	target	target	NOUN
dpc-4596	154	7	of	of	ADP
dpc-4596	154	8	rapamycin	rapamycin	NOUN
dpc-4596	154	9	;	;	PUNCT
dpc-4596	154	10	mtorc1	mtorc1	NOUN
dpc-4596	154	11	:	:	PUNCT
dpc-4596	154	12	mechanistic	mechanistic	ADJ
dpc-4596	154	13	target	target	NOUN
dpc-4596	154	14	of	of	ADP
dpc-4596	154	15	rapamycin	rapamycin	NOUN
dpc-4596	154	16	complex	complex	ADJ
dpc-4596	154	17	1	1	NUM
dpc-4596	154	18	;	;	PUNCT
dpc-4596	154	19	mtorc2	mtorc2	NOUN
dpc-4596	154	20	:	:	PUNCT
dpc-4596	154	21	mechanistic	mechanistic	ADJ
dpc-4596	154	22	target	target	NOUN
dpc-4596	154	23	of	of	ADP
dpc-4596	154	24	rapamycin	rapamycin	NOUN
dpc-4596	154	25	complex	complex	ADJ
dpc-4596	154	26	2	2	NUM
dpc-4596	154	27	;	;	PUNCT
dpc-4596	154	28	4ebp1	4ebp1	NUM
dpc-4596	154	29	:	:	PUNCT
dpc-4596	154	30	eukaryotic	eukaryotic	ADJ
dpc-4596	154	31	translation	translation	NOUN
dpc-4596	154	32	initiation	initiation	NOUN
dpc-4596	154	33	factor	factor	NOUN
dpc-4596	154	34	4ebinding	4ebinding	NUM
dpc-4596	154	35	protein	protein	NOUN
dpc-4596	154	36	1	1	NUM
dpc-4596	154	37	;	;	PUNCT
dpc-4596	154	38	pi3k	pi3k	NOUN
dpc-4596	154	39	:	:	PUNCT
dpc-4596	154	40	phosphoinositide-3	phosphoinositide-3	NUM
dpc-4596	154	41	-	-	PUNCT
dpc-4596	154	42	kinase	kinase	NOUN
dpc-4596	154	43	;	;	PUNCT
dpc-4596	154	44	elisa	elisa	NOUN
dpc-4596	154	45	:	:	PUNCT
dpc-4596	154	46	enzyme	enzyme	NOUN
dpc-4596	154	47	-	-	PUNCT
dpc-4596	154	48	linked	link	VERB
dpc-4596	154	49	immunosorbent	immunosorbent	NOUN
dpc-4596	154	50	assay	assay	ADV
dpc-4596	154	51	;	;	PUNCT
dpc-4596	154	52	s6k1	s6k1	NOUN
dpc-4596	154	53	:	:	PUNCT
dpc-4596	154	54	ribosomal	ribosomal	NOUN
dpc-4596	154	55	protein	protein	NOUN
dpc-4596	154	56	s6	s6	PROPN
dpc-4596	154	57	kinase	kinase	PROPN
dpc-4596	154	58	1	1	NUM
dpc-4596	154	59	;	;	PUNCT
dpc-4596	154	60	jak	jak	PROPN
dpc-4596	154	61	/	/	SYM
dpc-4596	154	62	stat	stat	PROPN
dpc-4596	154	63	:	:	PUNCT
dpc-4596	154	64	janus	janus	PROPN
dpc-4596	154	65	kinase	kinase	PROPN
dpc-4596	154	66	/	/	SYM
dpc-4596	154	67	signal	signal	NOUN
dpc-4596	154	68	transducers	transducer	NOUN
dpc-4596	154	69	and	and	CCONJ
dpc-4596	154	70	activators	activator	NOUN
dpc-4596	154	71	of	of	ADP
dpc-4596	154	72	transcription	transcription	NOUN
dpc-4596	154	73	;	;	PUNCT
dpc-4596	155	1	tlr	tlr	PROPN
dpc-4596	155	2	:	:	PUNCT
dpc-4596	155	3	toll	toll	NOUN
dpc-4596	155	4	-	-	PUNCT
dpc-4596	155	5	like	like	ADJ
dpc-4596	155	6	receptor	receptor	NOUN
dpc-4596	155	7	;	;	PUNCT
dpc-4596	155	8	jnk/	jnk/	PROPN
dpc-4596	155	9	mapk	mapk	NOUN
dpc-4596	155	10	:	:	PUNCT
dpc-4596	155	11	c	c	X
dpc-4596	155	12	-	-	PUNCT
dpc-4596	155	13	jun	jun	PROPN
dpc-4596	155	14	n	n	CCONJ
dpc-4596	155	15	-	-	PUNCT
dpc-4596	155	16	terminal	terminal	ADJ
dpc-4596	155	17	kinase	kinase	NOUN
dpc-4596	155	18	(	(	PUNCT
dpc-4596	155	19	jnk)mitogen	jnk)mitogen	PROPN
dpc-4596	155	20	-	-	PUNCT
dpc-4596	155	21	activated	activate	VERB
dpc-4596	155	22	protein	protein	NOUN
dpc-4596	155	23	kinase	kinase	NOUN
dpc-4596	155	24	.	.	PUNCT
dpc-4596	156	1	references	reference	NOUN
dpc-4596	156	2	1	1	NUM
dpc-4596	156	3	.	.	PUNCT
dpc-4596	157	1	armstrong	armstrong	PROPN
dpc-4596	157	2	aw	aw	PROPN
dpc-4596	157	3	,	,	PUNCT
dpc-4596	157	4	read	read	VERB
dpc-4596	157	5	c.	c.	PROPN
dpc-4596	157	6	pathophysiology	pathophysiology	NOUN
dpc-4596	157	7	,	,	PUNCT
dpc-4596	157	8	clinical	clinical	ADJ
dpc-4596	157	9	presentation	presentation	NOUN
dpc-4596	157	10	,	,	PUNCT
dpc-4596	157	11	and	and	CCONJ
dpc-4596	157	12	treatment	treatment	NOUN
dpc-4596	157	13	of	of	ADP
dpc-4596	157	14	psoriasis	psoriasis	NOUN
dpc-4596	157	15	:	:	PUNCT
dpc-4596	157	16	a	a	DET
dpc-4596	157	17	review	review	NOUN
dpc-4596	157	18	.	.	PUNCT
dpc-4596	158	1	jama	jama	PROPN
dpc-4596	158	2	.	.	PUNCT
dpc-4596	159	1	2020;323(19):194560	2020;323(19):194560	X
dpc-4596	159	2	.	.	PUNCT
dpc-4596	160	1	doi	doi	NOUN
dpc-4596	160	2	:	:	PUNCT
dpc-4596	160	3	10.1001	10.1001	NUM
dpc-4596	160	4	/	/	SYM
dpc-4596	160	5	jama.2020.4006	jama.2020.4006	ADJ
dpc-4596	160	6	.	.	PUNCT
dpc-4596	161	1	2	2	NUM
dpc-4596	161	2	.	.	X
dpc-4596	161	3	yamanaka	yamanaka	PROPN
dpc-4596	161	4	k	k	PROPN
dpc-4596	161	5	,	,	PUNCT
dpc-4596	161	6	yamamoto	yamamoto	PROPN
dpc-4596	161	7	o	o	PROPN
dpc-4596	161	8	,	,	PUNCT
dpc-4596	161	9	honda	honda	PROPN
dpc-4596	161	10	t.	t.	PROPN
dpc-4596	161	11	pathophysiology	pathophysiology	NOUN
dpc-4596	161	12	of	of	ADP
dpc-4596	161	13	psoriasis	psoriasis	NOUN
dpc-4596	161	14	:	:	PUNCT
dpc-4596	161	15	a	a	DET
dpc-4596	161	16	review	review	NOUN
dpc-4596	161	17	.	.	PUNCT
dpc-4596	162	1	j	j	PROPN
dpc-4596	162	2	dermatol	dermatol	NOUN
dpc-4596	162	3	.	.	PUNCT
dpc-4596	163	1	2021;48(6):722	2021;48(6):722	NUM
dpc-4596	163	2	-	-	SYM
dpc-4596	163	3	31	31	NUM
dpc-4596	163	4	.	.	PUNCT
dpc-4596	164	1	doi	doi	NOUN
dpc-4596	164	2	:	:	PUNCT
dpc-4596	164	3	10.1111	10.1111	NUM
dpc-4596	164	4	/1346	/1346	PUNCT
dpc-4596	164	5	-	-	PUNCT
dpc-4596	164	6	8138.15913	8138.15913	NUM
dpc-4596	164	7	.	.	PUNCT
dpc-4596	165	1	3	3	X
dpc-4596	165	2	.	.	X
dpc-4596	165	3	szwed	szwe	VERB
dpc-4596	165	4	a	a	PRON
dpc-4596	165	5	,	,	PUNCT
dpc-4596	165	6	kim	kim	PROPN
dpc-4596	165	7	e	e	PROPN
dpc-4596	165	8	,	,	PUNCT
dpc-4596	165	9	jacinto	jacinto	PROPN
dpc-4596	165	10	e.	e.	PROPN
dpc-4596	165	11	regulation	regulation	PROPN
dpc-4596	165	12	and	and	CCONJ
dpc-4596	165	13	metabolic	metabolic	NOUN
dpc-4596	165	14	functions	function	NOUN
dpc-4596	165	15	of	of	ADP
dpc-4596	165	16	mtorc1	mtorc1	NOUN
dpc-4596	165	17	and	and	CCONJ
dpc-4596	165	18	mtorc2	mtorc2	PROPN
dpc-4596	165	19	.	.	PUNCT
dpc-4596	166	1	physiol	physiol	PROPN
dpc-4596	166	2	rev	rev	VERB
dpc-4596	166	3	.	.	PROPN
dpc-4596	167	1	2021;101(3):1371426	2021;101(3):1371426	NUM
dpc-4596	167	2	.	.	PUNCT
dpc-4596	168	1	doi	doi	NOUN
dpc-4596	168	2	:	:	PUNCT
dpc-4596	168	3	10.1152	10.1152	NUM
dpc-4596	168	4	/	/	SYM
dpc-4596	168	5	physrev.00026.2020	physrev.00026.2020	NOUN
dpc-4596	168	6	.	.	PUNCT
dpc-4596	169	1	4	4	NUM
dpc-4596	169	2	.	.	X
dpc-4596	169	3	ersahin	ersahin	PROPN
dpc-4596	169	4	t	t	PROPN
dpc-4596	169	5	,	,	PUNCT
dpc-4596	169	6	tuncbag	tuncbag	NOUN
dpc-4596	169	7	n	n	CCONJ
dpc-4596	169	8	,	,	PUNCT
dpc-4596	169	9	cetin	cetin	ADJ
dpc-4596	169	10	-	-	PUNCT
dpc-4596	169	11	atalay	atalay	NOUN
dpc-4596	169	12	r.	r.	NOUN
dpc-4596	169	13	the	the	DET
dpc-4596	169	14	pi3k	pi3k	PROPN
dpc-4596	169	15	/	/	SYM
dpc-4596	169	16	akt	akt	PROPN
dpc-4596	169	17	/	/	SYM
dpc-4596	169	18	mtor	mtor	PROPN
dpc-4596	169	19	interactive	interactive	ADJ
dpc-4596	169	20	pathway	pathway	NOUN
dpc-4596	169	21	.	.	PUNCT
dpc-4596	170	1	mol	mol	ADP
dpc-4596	170	2	biosyst	biosyst	NOUN
dpc-4596	170	3	.	.	PUNCT
dpc-4596	171	1	2015;11(7):1946	2015;11(7):1946	NUM
dpc-4596	171	2	-	-	SYM
dpc-4596	171	3	54	54	NUM
dpc-4596	171	4	.	.	PUNCT
dpc-4596	172	1	doi	doi	NOUN
dpc-4596	172	2	:	:	PUNCT
dpc-4596	172	3	10.1039	10.1039	NUM
dpc-4596	172	4	/	/	SYM
dpc-4596	172	5	c5mb00101c	c5mb00101c	PROPN
dpc-4596	172	6	.	.	PROPN
dpc-4596	172	7	5	5	NUM
dpc-4596	172	8	.	.	PUNCT
dpc-4596	173	1	liu	liu	PROPN
dpc-4596	173	2	y	y	PROPN
dpc-4596	173	3	,	,	PUNCT
dpc-4596	173	4	zhang	zhang	PROPN
dpc-4596	173	5	dt	dt	PROPN
dpc-4596	173	6	,	,	PUNCT
dpc-4596	173	7	liu	liu	PROPN
dpc-4596	173	8	xg	xg	PROPN
dpc-4596	173	9	.	.	PUNCT
dpc-4596	173	10	mtor	mtor	PROPN
dpc-4596	173	11	signaling	signal	VERB
dpc-4596	173	12	in	in	ADP
dpc-4596	173	13	t	t	PROPN
dpc-4596	173	14	cell	cell	NOUN
dpc-4596	173	15	immunity	immunity	NOUN
dpc-4596	173	16	and	and	CCONJ
dpc-4596	173	17	autoimmunity	autoimmunity	NOUN
dpc-4596	173	18	.	.	PUNCT
dpc-4596	174	1	int	int	PROPN
dpc-4596	174	2	rev	rev	PROPN
dpc-4596	174	3	immunol	immunol	NOUN
dpc-4596	174	4	.	.	PUNCT
dpc-4596	175	1	2015;34(1):50	2015;34(1):50	X
dpc-4596	175	2	-	-	SYM
dpc-4596	175	3	66	66	NUM
dpc-4596	175	4	.	.	PUNCT
dpc-4596	176	1	doi	doi	NOUN
dpc-4596	176	2	:	:	PUNCT
dpc-4596	176	3	10.3109/08830185.2014.933957	10.3109/08830185.2014.933957	NUM
dpc-4596	176	4	.	.	X
dpc-4596	177	1	6	6	NUM
dpc-4596	177	2	.	.	X
dpc-4596	178	1	wang	wang	PROPN
dpc-4596	178	2	j	j	PROPN
dpc-4596	178	3	,	,	PUNCT
dpc-4596	178	4	cui	cui	PROPN
dpc-4596	178	5	b	b	PROPN
dpc-4596	178	6	,	,	PUNCT
dpc-4596	178	7	chen	chen	PROPN
dpc-4596	178	8	z	z	PROPN
dpc-4596	178	9	,	,	PUNCT
dpc-4596	178	10	ding	de	VERB
dpc-4596	178	11	x.	x.	NOUN
dpc-4596	178	12	the	the	DET
dpc-4596	178	13	regulation	regulation	NOUN
dpc-4596	178	14	of	of	ADP
dpc-4596	178	15	skin	skin	NOUN
dpc-4596	178	16	homeostasis	homeostasis	NOUN
dpc-4596	178	17	,	,	PUNCT
dpc-4596	178	18	repair	repair	NOUN
dpc-4596	178	19	and	and	CCONJ
dpc-4596	178	20	the	the	DET
dpc-4596	178	21	pathogenesis	pathogenesis	NOUN
dpc-4596	178	22	of	of	ADP
dpc-4596	178	23	skin	skin	NOUN
dpc-4596	178	24	diseases	disease	NOUN
dpc-4596	178	25	by	by	ADP
dpc-4596	178	26	spatiotemporal	spatiotemporal	ADJ
dpc-4596	178	27	activation	activation	NOUN
dpc-4596	178	28	of	of	ADP
dpc-4596	178	29	epidermal	epidermal	ADJ
dpc-4596	178	30	mtor	mtor	NOUN
dpc-4596	178	31	signaling	signaling	NOUN
dpc-4596	178	32	.	.	PUNCT
dpc-4596	179	1	front	front	ADJ
dpc-4596	179	2	cell	cell	NOUN
dpc-4596	179	3	dev	dev	PROPN
dpc-4596	179	4	biol	biol	NOUN
dpc-4596	179	5	.	.	PUNCT
dpc-4596	180	1	2022;10:950973	2022;10:950973	X
dpc-4596	180	2	.	.	PUNCT
dpc-4596	180	3	 	 	SPACE
dpc-4596	180	4	doi	doi	NOUN
dpc-4596	180	5	:	:	PUNCT
dpc-4596	180	6	10.3389	10.3389	NUM
dpc-4596	180	7	/	/	SYM
dpc-4596	180	8	fcell.2022.950973	fcell.2022.950973	NOUN
dpc-4596	180	9	.	.	PUNCT
dpc-4596	181	1	7	7	X
dpc-4596	181	2	.	.	X
dpc-4596	181	3	ding	ding	NOUN
dpc-4596	181	4	x	x	PROPN
dpc-4596	181	5	,	,	PUNCT
dpc-4596	181	6	bloch	bloch	PROPN
dpc-4596	181	7	w	w	PROPN
dpc-4596	181	8	,	,	PUNCT
dpc-4596	181	9	iden	iden	PROPN
dpc-4596	181	10	s	s	PART
dpc-4596	181	11	,	,	PUNCT
dpc-4596	181	12	ruegg	ruegg	PROPN
dpc-4596	181	13	ma	ma	PROPN
dpc-4596	181	14	,	,	PUNCT
dpc-4596	181	15	hall	hall	PROPN
dpc-4596	181	16	mn	mn	PROPN
dpc-4596	181	17	,	,	PUNCT
dpc-4596	181	18	leptin	leptin	PROPN
dpc-4596	181	19	m	m	PROPN
dpc-4596	181	20	,	,	PUNCT
dpc-4596	181	21	et	et	PROPN
dpc-4596	181	22	al	al	PROPN
dpc-4596	181	23	.	.	PUNCT
dpc-4596	182	1	mtorc1	mtorc1	PROPN
dpc-4596	182	2	and	and	CCONJ
dpc-4596	182	3	mtorc2	mtorc2	NOUN
dpc-4596	182	4	regulate	regulate	VERB
dpc-4596	182	5	skin	skin	NOUN
dpc-4596	182	6	morphogenesis	morphogenesis	NOUN
dpc-4596	182	7	and	and	CCONJ
dpc-4596	182	8	that	that	SCONJ
dpc-4596	182	9	agents	agent	NOUN
dpc-4596	182	10	capable	capable	ADJ
dpc-4596	182	11	of	of	ADP
dpc-4596	182	12	effectively	effectively	ADV
dpc-4596	182	13	inhibiting	inhibit	VERB
dpc-4596	182	14	both	both	DET
dpc-4596	182	15	mtor	mtor	NOUN
dpc-4596	182	16	complexes	complex	NOUN
dpc-4596	182	17	,	,	PUNCT
dpc-4596	182	18	rather	rather	ADV
dpc-4596	182	19	than	than	ADP
dpc-4596	182	20	solely	solely	ADV
dpc-4596	182	21	mtorc1	mtorc1	NOUN
dpc-4596	182	22	,	,	PUNCT
dpc-4596	182	23	may	may	AUX
dpc-4596	182	24	offer	offer	VERB
dpc-4596	182	25	greater	great	ADJ
dpc-4596	182	26	potential	potential	NOUN
dpc-4596	182	27	for	for	ADP
dpc-4596	182	28	the	the	DET
dpc-4596	182	29	treatment	treatment	NOUN
dpc-4596	182	30	of	of	ADP
dpc-4596	182	31	psoriasis	psoriasis	NOUN
dpc-4596	182	32	[	[	X
dpc-4596	182	33	21	21	NUM
dpc-4596	182	34	]	]	PUNCT
dpc-4596	182	35	.	.	PUNCT
dpc-4596	183	1	chamcheu	chamcheu	AUX
dpc-4596	183	2	et	et	PROPN
dpc-4596	183	3	al	al	PROPN
dpc-4596	183	4	.	.	PROPN
dpc-4596	183	5	demonstrated	demonstrate	VERB
dpc-4596	183	6	that	that	SCONJ
dpc-4596	183	7	the	the	DET
dpc-4596	183	8	molecule	molecule	NOUN
dpc-4596	183	9	delphinidin	delphinidin	NOUN
dpc-4596	183	10	,	,	PUNCT
dpc-4596	183	11	a	a	DET
dpc-4596	183	12	naturally	naturally	ADV
dpc-4596	183	13	occurring	occur	VERB
dpc-4596	183	14	antioxidant	antioxidant	ADJ
dpc-4596	183	15	pigment	pigment	NOUN
dpc-4596	183	16	,	,	PUNCT
dpc-4596	183	17	could	could	AUX
dpc-4596	183	18	provide	provide	VERB
dpc-4596	183	19	improvement	improvement	NOUN
dpc-4596	183	20	in	in	ADP
dpc-4596	183	21	psoriasis	psoriasis	NOUN
dpc-4596	183	22	lesions	lesion	NOUN
dpc-4596	183	23	in	in	ADP
dpc-4596	183	24	imiquimod	imiquimod	ADJ
dpc-4596	183	25	-	-	PUNCT
dpc-4596	183	26	induced	induce	VERB
dpc-4596	183	27	psoriasis	psoriasis	NOUN
dpc-4596	183	28	mouse	mouse	NOUN
dpc-4596	183	29	models	model	NOUN
dpc-4596	183	30	by	by	ADP
dpc-4596	183	31	effectively	effectively	ADV
dpc-4596	183	32	inhibiting	inhibit	VERB
dpc-4596	183	33	the	the	DET
dpc-4596	183	34	pi3k	pi3k	PROPN
dpc-4596	183	35	/	/	SYM
dpc-4596	183	36	akt	akt	PROPN
dpc-4596	183	37	/	/	SYM
dpc-4596	183	38	mtor	mtor	PROPN
dpc-4596	183	39	pathway	pathway	NOUN
dpc-4596	184	1	[	[	X
dpc-4596	184	2	22	22	NUM
dpc-4596	184	3	]	]	PUNCT
dpc-4596	184	4	.	.	PUNCT
dpc-4596	185	1	in	in	ADP
dpc-4596	185	2	a	a	DET
dpc-4596	185	3	study	study	NOUN
dpc-4596	185	4	conducted	conduct	VERB
dpc-4596	185	5	by	by	ADP
dpc-4596	185	6	roy	roy	PROPN
dpc-4596	185	7	et	et	PROPN
dpc-4596	185	8	al	al	PROPN
dpc-4596	185	9	.	.	PROPN
dpc-4596	185	10	in	in	ADP
dpc-4596	185	11	2023	2023	NUM
dpc-4596	185	12	,	,	PUNCT
dpc-4596	185	13	the	the	DET
dpc-4596	185	14	effectiveness	effectiveness	NOUN
dpc-4596	185	15	of	of	ADP
dpc-4596	185	16	an	an	DET
dpc-4596	185	17	antioxidant	antioxidant	ADJ
dpc-4596	185	18	and	and	CCONJ
dpc-4596	185	19	antiproliferative	antiproliferative	ADJ
dpc-4596	185	20	dietary	dietary	ADJ
dpc-4596	185	21	polyphenol	polyphenol	NOUN
dpc-4596	185	22	,	,	PUNCT
dpc-4596	185	23	fisetin	fisetin	NOUN
dpc-4596	185	24	,	,	PUNCT
dpc-4596	185	25	on	on	ADP
dpc-4596	185	26	psoriasis	psoriasis	NOUN
dpc-4596	185	27	was	be	AUX
dpc-4596	185	28	demonstrated	demonstrate	VERB
dpc-4596	185	29	both	both	PRON
dpc-4596	185	30	in	in	ADP
dpc-4596	185	31	vitro	vitro	X
dpc-4596	185	32	and	and	CCONJ
dpc-4596	185	33	in	in	ADP
dpc-4596	185	34	vivo	vivo	NOUN
dpc-4596	185	35	.	.	PUNCT
dpc-4596	186	1	fisetin	fisetin	PROPN
dpc-4596	186	2	inhibits	inhibit	VERB
dpc-4596	186	3	s6k	s6k	PROPN
dpc-4596	186	4	and	and	CCONJ
dpc-4596	186	5	mtor	mtor	NOUN
dpc-4596	186	6	by	by	ADP
dpc-4596	186	7	covalently	covalently	ADV
dpc-4596	186	8	binding	bind	VERB
dpc-4596	186	9	and	and	CCONJ
dpc-4596	186	10	reduces	reduce	VERB
dpc-4596	186	11	pi3k	pi3k	PROPN
dpc-4596	186	12	/	/	SYM
dpc-4596	186	13	akt	akt	PROPN
dpc-4596	186	14	/	/	SYM
dpc-4596	186	15	mtor	mtor	PROPN
dpc-4596	186	16	pathway	pathway	NOUN
dpc-4596	186	17	activation	activation	NOUN
dpc-4596	186	18	.	.	PUNCT
dpc-4596	187	1	the	the	DET
dpc-4596	187	2	authors	author	NOUN
dpc-4596	187	3	hypothesize	hypothesize	VERB
dpc-4596	187	4	that	that	SCONJ
dpc-4596	187	5	fisetin	fisetin	NOUN
dpc-4596	187	6	-	-	PUNCT
dpc-4596	187	7	induced	induce	VERB
dpc-4596	187	8	improvement	improvement	NOUN
dpc-4596	187	9	of	of	ADP
dpc-4596	187	10	these	these	PRON
dpc-4596	187	11	in	in	ADP
dpc-4596	187	12	vitro	vitro	X
dpc-4596	187	13	and	and	CCONJ
dpc-4596	187	14	in	in	ADP
dpc-4596	187	15	vivo	vivo	ADJ
dpc-4596	187	16	inflammatory	inflammatory	ADJ
dpc-4596	187	17	responses	response	NOUN
dpc-4596	187	18	in	in	ADP
dpc-4596	187	19	psoriasis	psoriasis	NOUN
dpc-4596	187	20	is	be	AUX
dpc-4596	187	21	associated	associate	VERB
dpc-4596	187	22	with	with	ADP
dpc-4596	187	23	mtor	mtor	NOUN
dpc-4596	187	24	-	-	PUNCT
dpc-4596	187	25	centered	center	VERB
dpc-4596	187	26	signaling	signaling	NOUN
dpc-4596	187	27	inhibition	inhibition	NOUN
dpc-4596	187	28	[	[	X
dpc-4596	187	29	23	23	NUM
dpc-4596	187	30	]	]	PUNCT
dpc-4596	187	31	.	.	PUNCT
dpc-4596	188	1	we	we	PRON
dpc-4596	188	2	found	find	VERB
dpc-4596	188	3	a	a	DET
dpc-4596	188	4	positive	positive	ADJ
dpc-4596	188	5	correlation	correlation	NOUN
dpc-4596	188	6	was	be	AUX
dpc-4596	188	7	observed	observe	VERB
dpc-4596	188	8	between	between	ADP
dpc-4596	188	9	serum	serum	NOUN
dpc-4596	188	10	mtorc1	mtorc1	NOUN
dpc-4596	188	11	levels	level	NOUN
dpc-4596	188	12	and	and	CCONJ
dpc-4596	188	13	serum	serum	NOUN
dpc-4596	188	14	mtorc2	mtorc2	PROPN
dpc-4596	188	15	levels	level	NOUN
dpc-4596	188	16	in	in	ADP
dpc-4596	188	17	patients	patient	NOUN
dpc-4596	188	18	,	,	PUNCT
dpc-4596	188	19	which	which	PRON
dpc-4596	188	20	lends	lend	VERB
dpc-4596	188	21	support	support	NOUN
dpc-4596	188	22	to	to	ADP
dpc-4596	188	23	the	the	DET
dpc-4596	188	24	hypothesis	hypothesis	NOUN
dpc-4596	188	25	that	that	PRON
dpc-4596	188	26	both	both	DET
dpc-4596	188	27	complexes	complex	NOUN
dpc-4596	188	28	play	play	VERB
dpc-4596	188	29	an	an	DET
dpc-4596	188	30	important	important	ADJ
dpc-4596	188	31	role	role	NOUN
dpc-4596	188	32	in	in	ADP
dpc-4596	188	33	the	the	DET
dpc-4596	188	34	pathogenesis	pathogenesis	NOUN
dpc-4596	188	35	of	of	ADP
dpc-4596	188	36	psoriasis	psoriasis	NOUN
dpc-4596	188	37	.	.	PUNCT
dpc-4596	189	1	psoriasis	psoriasis	NOUN
dpc-4596	189	2	is	be	AUX
dpc-4596	189	3	regarded	regard	VERB
dpc-4596	189	4	as	as	ADP
dpc-4596	189	5	a	a	DET
dpc-4596	189	6	systemic	systemic	ADJ
dpc-4596	189	7	disease	disease	NOUN
dpc-4596	189	8	,	,	PUNCT
dpc-4596	189	9	with	with	ADP
dpc-4596	189	10	a	a	DET
dpc-4596	189	11	high	high	ADJ
dpc-4596	189	12	prevalence	prevalence	NOUN
dpc-4596	189	13	of	of	ADP
dpc-4596	189	14	cardiovascular	cardiovascular	ADJ
dpc-4596	189	15	comorbidities	comorbiditie	NOUN
dpc-4596	189	16	.	.	PUNCT
dpc-4596	190	1	recent	recent	ADJ
dpc-4596	190	2	studies	study	NOUN
dpc-4596	190	3	have	have	AUX
dpc-4596	190	4	indicated	indicate	VERB
dpc-4596	190	5	that	that	SCONJ
dpc-4596	190	6	mtor	mtor	NOUN
dpc-4596	190	7	activation	activation	NOUN
dpc-4596	190	8	may	may	AUX
dpc-4596	190	9	play	play	VERB
dpc-4596	190	10	a	a	DET
dpc-4596	190	11	pivotal	pivotal	ADJ
dpc-4596	190	12	role	role	NOUN
dpc-4596	190	13	in	in	ADP
dpc-4596	190	14	the	the	DET
dpc-4596	190	15	development	development	NOUN
dpc-4596	190	16	of	of	ADP
dpc-4596	190	17	atherosclerotic	atherosclerotic	ADJ
dpc-4596	190	18	plaques	plaque	NOUN
dpc-4596	190	19	[	[	X
dpc-4596	190	20	24,25	24,25	NUM
dpc-4596	190	21	]	]	PUNCT
dpc-4596	190	22	.	.	PUNCT
dpc-4596	191	1	loyola	loyola	PROPN
dpc-4596	191	2	and	and	CCONJ
dpc-4596	191	3	colleagues	colleague	NOUN
dpc-4596	191	4	focused	focus	VERB
dpc-4596	191	5	on	on	ADP
dpc-4596	191	6	the	the	DET
dpc-4596	191	7	identification	identification	NOUN
dpc-4596	191	8	of	of	ADP
dpc-4596	191	9	novel	novel	ADJ
dpc-4596	191	10	biomarkers	biomarker	NOUN
dpc-4596	191	11	for	for	ADP
dpc-4596	191	12	cardiovascular	cardiovascular	ADJ
dpc-4596	191	13	disease	disease	NOUN
dpc-4596	191	14	in	in	ADP
dpc-4596	191	15	patients	patient	NOUN
dpc-4596	191	16	with	with	ADP
dpc-4596	191	17	psoriasis	psoriasis	NOUN
dpc-4596	191	18	.	.	PUNCT
dpc-4596	192	1	they	they	PRON
dpc-4596	192	2	analyzed	analyze	VERB
dpc-4596	192	3	mtor	mtor	NOUN
dpc-4596	192	4	activation	activation	NOUN
dpc-4596	192	5	via	via	ADP
dpc-4596	192	6	the	the	DET
dpc-4596	192	7	detection	detection	NOUN
dpc-4596	192	8	of	of	ADP
dpc-4596	192	9	phosphorylation	phosphorylation	NOUN
dpc-4596	192	10	of	of	ADP
dpc-4596	192	11	s6r	s6r	PROPN
dpc-4596	192	12	protein	protein	NOUN
dpc-4596	192	13	,	,	PUNCT
dpc-4596	192	14	a	a	DET
dpc-4596	192	15	substrate	substrate	NOUN
dpc-4596	192	16	of	of	ADP
dpc-4596	192	17	the	the	DET
dpc-4596	192	18	mtorc-1	mtorc-1	NUM
dpc-4596	192	19	protein	protein	NOUN
dpc-4596	192	20	synthesis	synthesis	NOUN
dpc-4596	192	21	pathway	pathway	NOUN
dpc-4596	192	22	,	,	PUNCT
dpc-4596	192	23	in	in	ADP
dpc-4596	192	24	extracted	extract	VERB
dpc-4596	192	25	mononuclear	mononuclear	ADJ
dpc-4596	192	26	cells	cell	NOUN
dpc-4596	192	27	from	from	ADP
dpc-4596	192	28	10	10	NUM
dpc-4596	192	29	patients	patient	NOUN
dpc-4596	192	30	with	with	ADP
dpc-4596	192	31	psoriasis	psoriasis	NOUN
dpc-4596	192	32	and	and	CCONJ
dpc-4596	192	33	compared	compare	VERB
dpc-4596	192	34	this	this	PRON
dpc-4596	192	35	with	with	ADP
dpc-4596	192	36	11	11	NUM
dpc-4596	192	37	healthy	healthy	ADJ
dpc-4596	192	38	individuals	individual	NOUN
dpc-4596	192	39	[	[	X
dpc-4596	192	40	26	26	NUM
dpc-4596	192	41	]	]	PUNCT
dpc-4596	192	42	.	.	PUNCT
dpc-4596	193	1	the	the	DET
dpc-4596	193	2	study	study	NOUN
dpc-4596	193	3	revealed	reveal	VERB
dpc-4596	193	4	elevated	elevated	ADJ
dpc-4596	193	5	levels	level	NOUN
dpc-4596	193	6	of	of	ADP
dpc-4596	193	7	s6rp	s6rp	PRON
dpc-4596	193	8	in	in	ADP
dpc-4596	193	9	psoriatic	psoriatic	ADJ
dpc-4596	193	10	patients	patient	NOUN
dpc-4596	193	11	,	,	PUNCT
dpc-4596	193	12	particularly	particularly	ADV
dpc-4596	193	13	in	in	ADP
dpc-4596	193	14	m2	m2	PROPN
dpc-4596	193	15	monocytes	monocyte	NOUN
dpc-4596	193	16	.	.	PUNCT
dpc-4596	194	1	the	the	DET
dpc-4596	194	2	authors	author	NOUN
dpc-4596	194	3	proposed	propose	VERB
dpc-4596	194	4	that	that	SCONJ
dpc-4596	194	5	mtor	mtor	PROPN
dpc-4596	194	6	activity	activity	NOUN
dpc-4596	194	7	may	may	AUX
dpc-4596	194	8	serve	serve	VERB
dpc-4596	194	9	as	as	ADP
dpc-4596	194	10	an	an	DET
dpc-4596	194	11	early	early	ADJ
dpc-4596	194	12	marker	marker	NOUN
dpc-4596	194	13	of	of	ADP
dpc-4596	194	14	cardiovascular	cardiovascular	ADJ
dpc-4596	194	15	risk	risk	NOUN
dpc-4596	194	16	in	in	ADP
dpc-4596	194	17	psoriatic	psoriatic	ADJ
dpc-4596	194	18	patients	patient	NOUN
dpc-4596	194	19	[	[	X
dpc-4596	194	20	26	26	NUM
dpc-4596	194	21	]	]	PUNCT
dpc-4596	194	22	.	.	PUNCT
dpc-4596	195	1	consequently	consequently	ADV
dpc-4596	195	2	,	,	PUNCT
dpc-4596	195	3	mtor	mtor	NOUN
dpc-4596	195	4	activation	activation	NOUN
dpc-4596	195	5	in	in	ADP
dpc-4596	195	6	patients	patient	NOUN
dpc-4596	195	7	with	with	ADP
dpc-4596	195	8	psoriasis	psoriasis	NOUN
dpc-4596	195	9	may	may	AUX
dpc-4596	195	10	be	be	AUX
dpc-4596	195	11	a	a	DET
dpc-4596	195	12	contributing	contribute	VERB
dpc-4596	195	13	factor	factor	NOUN
dpc-4596	195	14	in	in	ADP
dpc-4596	195	15	the	the	DET
dpc-4596	195	16	increased	increase	VERB
dpc-4596	195	17	prevalence	prevalence	NOUN
dpc-4596	195	18	of	of	ADP
dpc-4596	195	19	cardiovascular	cardiovascular	ADJ
dpc-4596	195	20	disease	disease	NOUN
dpc-4596	195	21	.	.	PUNCT
dpc-4596	196	1	further	further	ADJ
dpc-4596	196	2	research	research	NOUN
dpc-4596	196	3	on	on	ADP
dpc-4596	196	4	the	the	DET
dpc-4596	196	5	levels	level	NOUN
dpc-4596	196	6	of	of	ADP
dpc-4596	196	7	mtor	mtor	NOUN
dpc-4596	196	8	in	in	ADP
dpc-4596	196	9	patients	patient	NOUN
dpc-4596	196	10	with	with	ADP
dpc-4596	196	11	psoriasis	psoriasis	NOUN
dpc-4596	196	12	with	with	ADP
dpc-4596	196	13	and	and	CCONJ
dpc-4596	196	14	without	without	ADP
dpc-4596	196	15	cardiovascular	cardiovascular	ADJ
dpc-4596	196	16	comorbidities	comorbiditie	NOUN
dpc-4596	196	17	may	may	AUX
dpc-4596	196	18	elucidate	elucidate	VERB
dpc-4596	196	19	this	this	DET
dpc-4596	196	20	potential	potential	ADJ
dpc-4596	196	21	relationship	relationship	NOUN
dpc-4596	196	22	.	.	PUNCT
dpc-4596	197	1	there	there	PRON
dpc-4596	197	2	are	be	VERB
dpc-4596	197	3	several	several	ADJ
dpc-4596	197	4	weak	weak	ADJ
dpc-4596	197	5	points	point	NOUN
dpc-4596	197	6	in	in	ADP
dpc-4596	197	7	this	this	DET
dpc-4596	197	8	study	study	NOUN
dpc-4596	197	9	.	.	PUNCT
dpc-4596	198	1	firstly	firstly	ADV
dpc-4596	198	2	,	,	PUNCT
dpc-4596	198	3	although	although	SCONJ
dpc-4596	198	4	serum	serum	NOUN
dpc-4596	198	5	mtorc1	mtorc1	NOUN
dpc-4596	198	6	and	and	CCONJ
dpc-4596	198	7	mtorc2	mtorc2	NOUN
dpc-4596	198	8	levels	level	NOUN
dpc-4596	198	9	of	of	ADP
dpc-4596	198	10	patients	patient	NOUN
dpc-4596	198	11	with	with	ADP
dpc-4596	198	12	plaque	plaque	NOUN
dpc-4596	198	13	psoriasis	psoriasis	NOUN
dpc-4596	198	14	are	be	AUX
dpc-4596	198	15	significantly	significantly	ADV
dpc-4596	198	16	lower	low	ADJ
dpc-4596	198	17	,	,	PUNCT
dpc-4596	198	18	it	it	PRON
dpc-4596	198	19	is	be	AUX
dpc-4596	198	20	not	not	PART
dpc-4596	198	21	known	know	VERB
dpc-4596	198	22	how	how	SCONJ
dpc-4596	198	23	mtorc1	mtorc1	NOUN
dpc-4596	198	24	and	and	CCONJ
dpc-4596	198	25	mtorc2	mtorc2	NOUN
dpc-4596	198	26	expression	expression	NOUN
dpc-4596	198	27	changes	change	NOUN
dpc-4596	198	28	at	at	ADP
dpc-4596	198	29	the	the	DET
dpc-4596	198	30	level	level	NOUN
dpc-4596	198	31	of	of	ADP
dpc-4596	198	32	psoriatic	psoriatic	ADJ
dpc-4596	198	33	plaques	plaque	NOUN
dpc-4596	198	34	because	because	SCONJ
dpc-4596	198	35	immunohistochemistry	immunohistochemistry	NOUN
dpc-4596	198	36	was	be	AUX
dpc-4596	198	37	not	not	PART
dpc-4596	198	38	performed	perform	VERB
dpc-4596	198	39	.	.	PUNCT
dpc-4596	199	1	while	while	SCONJ
dpc-4596	199	2	the	the	DET
dpc-4596	199	3	literature	literature	NOUN
dpc-4596	199	4	indicates	indicate	VERB
dpc-4596	199	5	an	an	DET
dpc-4596	199	6	increase	increase	NOUN
dpc-4596	199	7	in	in	ADP
dpc-4596	199	8	mtor	mtor	NOUN
dpc-4596	199	9	expression	expression	NOUN
dpc-4596	199	10	in	in	ADP
dpc-4596	199	11	psoriatic	psoriatic	ADJ
dpc-4596	199	12	plaques	plaque	NOUN
dpc-4596	199	13	,	,	PUNCT
dpc-4596	199	14	it	it	PRON
dpc-4596	199	15	is	be	AUX
dpc-4596	199	16	challenging	challenge	VERB
dpc-4596	199	17	to	to	PART
dpc-4596	199	18	ascertain	ascertain	VERB
dpc-4596	199	19	a	a	DET
dpc-4596	199	20	direct	direct	ADJ
dpc-4596	199	21	correlation	correlation	NOUN
dpc-4596	199	22	between	between	ADP
dpc-4596	199	23	serum	serum	NOUN
dpc-4596	199	24	levels	level	NOUN
dpc-4596	199	25	and	and	CCONJ
dpc-4596	199	26	the	the	DET
dpc-4596	199	27	disease	disease	NOUN
dpc-4596	199	28	.	.	PUNCT
dpc-4596	200	1	secondly	secondly	ADV
dpc-4596	200	2	,	,	PUNCT
dpc-4596	200	3	the	the	DET
dpc-4596	200	4	number	number	NOUN
dpc-4596	200	5	of	of	ADP
dpc-4596	200	6	patients	patient	NOUN
dpc-4596	200	7	with	with	ADP
dpc-4596	200	8	moderate	moderate	ADJ
dpc-4596	200	9	-	-	PUNCT
dpc-4596	200	10	to	to	ADP
dpc-4596	200	11	-	-	PUNCT
dpc-4596	200	12	severe	severe	ADJ
dpc-4596	200	13	plaque	plaque	NOUN
dpc-4596	200	14	psoriasis	psoriasis	NOUN
dpc-4596	200	15	was	be	AUX
dpc-4596	200	16	limited	limit	VERB
dpc-4596	200	17	,	,	PUNCT
dpc-4596	200	18	which	which	PRON
dpc-4596	200	19	precluded	preclude	VERB
dpc-4596	200	20	the	the	DET
dpc-4596	200	21	ability	ability	NOUN
dpc-4596	200	22	to	to	PART
dpc-4596	200	23	ascertain	ascertain	VERB
dpc-4596	200	24	the	the	DET
dpc-4596	200	25	relationship	relationship	NOUN
dpc-4596	200	26	between	between	ADP
dpc-4596	200	27	mtorcs	mtorcs	NOUN
dpc-4596	200	28	and	and	CCONJ
dpc-4596	200	29	disease	disease	NOUN
dpc-4596	200	30	severity	severity	NOUN
dpc-4596	200	31	.	.	PUNCT
dpc-4596	201	1	thirdly	thirdly	ADV
dpc-4596	201	2	,	,	PUNCT
dpc-4596	201	3	in	in	ADP
dpc-4596	201	4	order	order	NOUN
dpc-4596	201	5	to	to	PART
dpc-4596	201	6	gain	gain	VERB
dpc-4596	201	7	a	a	DET
dpc-4596	201	8	8	8	NUM
dpc-4596	201	9	original	original	ADJ
dpc-4596	201	10	article	article	NOUN
dpc-4596	201	11	|	|	ADV
dpc-4596	201	12	dermatol	dermatol	ADJ
dpc-4596	201	13	pract	pract	NOUN
dpc-4596	201	14	concept	concept	NOUN
dpc-4596	201	15	.	.	PUNCT
dpc-4596	202	1	2024;14(4):e2024266	2024;14(4):e2024266	NUM
dpc-4596	202	2	psoriasis	psoriasis	NOUN
dpc-4596	202	3	pathogenesis	pathogenesis	NOUN
dpc-4596	202	4	.	.	PUNCT
dpc-4596	203	1	a	a	DET
dpc-4596	203	2	potential	potential	ADJ
dpc-4596	203	3	therapeutic	therapeutic	ADJ
dpc-4596	203	4	target	target	NOUN
dpc-4596	203	5	?	?	PUNCT
dpc-4596	204	1	acta	acta	PROPN
dpc-4596	204	2	derm	derm	PROPN
dpc-4596	204	3	venereol	venereol	NOUN
dpc-4596	204	4	.	.	PUNCT
dpc-4596	205	1	2014;94(4):371	2014;94(4):371	NUM
dpc-4596	205	2	-	-	SYM
dpc-4596	205	3	9	9	NUM
dpc-4596	205	4	.	.	PUNCT
dpc-4596	205	5	doi	doi	NOUN
dpc-4596	205	6	:	:	PUNCT
dpc-4596	205	7	10.2340/00015555	10.2340/00015555	NUM
dpc-4596	205	8	-	-	SYM
dpc-4596	205	9	1737	1737	NUM
dpc-4596	205	10	.	.	PUNCT
dpc-4596	206	1	18	18	NUM
dpc-4596	206	2	.	.	X
dpc-4596	206	3	yu	yu	PROPN
dpc-4596	206	4	j	j	PROPN
dpc-4596	206	5	,	,	PUNCT
dpc-4596	206	6	zhao	zhao	PROPN
dpc-4596	206	7	q	q	PROPN
dpc-4596	206	8	,	,	PUNCT
dpc-4596	206	9	wang	wang	PROPN
dpc-4596	206	10	x	x	PROPN
dpc-4596	206	11	,	,	PUNCT
dpc-4596	206	12	et	et	PROPN
dpc-4596	206	13	al	al	PROPN
dpc-4596	206	14	.	.	PUNCT
dpc-4596	206	15	pathogenesis	pathogenesis	PROPN
dpc-4596	206	16	,	,	PUNCT
dpc-4596	206	17	multi	multi	ADJ
dpc-4596	206	18	-	-	ADJ
dpc-4596	206	19	omics	omics	ADJ
dpc-4596	206	20	research	research	NOUN
dpc-4596	206	21	,	,	PUNCT
dpc-4596	206	22	and	and	CCONJ
dpc-4596	206	23	clinical	clinical	ADJ
dpc-4596	206	24	treatment	treatment	NOUN
dpc-4596	206	25	of	of	ADP
dpc-4596	206	26	psoriasis	psoriasis	NOUN
dpc-4596	206	27	.	.	PUNCT
dpc-4596	207	1	j	j	PROPN
dpc-4596	207	2	autoimmun	autoimmun	PROPN
dpc-4596	207	3	.	.	PUNCT
dpc-4596	208	1	2022	2022	NUM
dpc-4596	208	2	;	;	PUNCT
dpc-4596	209	1	133:102916	133:102916	NUM
dpc-4596	209	2	.	.	PUNCT
dpc-4596	209	3	doi	doi	NOUN
dpc-4596	209	4	:	:	PUNCT
dpc-4596	209	5	10.1016	10.1016	NUM
dpc-4596	209	6	/	/	SYM
dpc-4596	209	7	j.jaut.2022.102916	j.jaut.2022.102916	PROPN
dpc-4596	209	8	.	.	PUNCT
dpc-4596	210	1	19	19	NUM
dpc-4596	210	2	.	.	PUNCT
dpc-4596	210	3	cheng	cheng	PROPN
dpc-4596	210	4	mm	mm	PROPN
dpc-4596	210	5	w	w	PROPN
dpc-4596	210	6	,	,	PUNCT
dpc-4596	210	7	long	long	ADJ
dpc-4596	210	8	y	y	PROPN
dpc-4596	210	9	,	,	PUNCT
dpc-4596	210	10	wang	wang	PROPN
dpc-4596	210	11	h	h	PROPN
dpc-4596	210	12	,	,	PUNCT
dpc-4596	210	13	han	han	PROPN
dpc-4596	210	14	mm	mm	PROPN
dpc-4596	210	15	w	w	PROPN
dpc-4596	210	16	,	,	PUNCT
dpc-4596	210	17	zhang	zhang	PROPN
dpc-4596	210	18	j	j	PROPN
dpc-4596	210	19	,	,	PUNCT
dpc-4596	210	20	cui	cui	PROPN
dpc-4596	210	21	n.	n.	ADJ
dpc-4596	210	22	role	role	NOUN
dpc-4596	210	23	of	of	ADP
dpc-4596	210	24	the	the	DET
dpc-4596	210	25	mtor	mtor	NOUN
dpc-4596	210	26	signalling	signal	VERB
dpc-4596	210	27	pathway	pathway	NOUN
dpc-4596	210	28	in	in	ADP
dpc-4596	210	29	human	human	ADJ
dpc-4596	210	30	sepsis	sepsis	NOUN
dpc-4596	210	31	induced	induce	VERB
dpc-4596	210	32	myocardial	myocardial	ADJ
dpc-4596	210	33	dysfunction	dysfunction	NOUN
dpc-4596	210	34	.	.	PUNCT
dpc-4596	211	1	can	can	AUX
dpc-4596	211	2	j	j	PROPN
dpc-4596	211	3	cardiol	cardiol	VERB
dpc-4596	211	4	.	.	PUNCT
dpc-4596	212	1	2019;35(7	2019;35(7	NUM
dpc-4596	212	2	):	):	PUNCT
dpc-4596	212	3	875	875	NUM
dpc-4596	212	4	-	-	SYM
dpc-4596	212	5	83	83	NUM
dpc-4596	212	6	.	.	PUNCT
dpc-4596	212	7	 	 	SPACE
dpc-4596	213	1	doi	doi	NOUN
dpc-4596	213	2	:	:	PUNCT
dpc-4596	213	3	10.1016	10.1016	NUM
dpc-4596	213	4	/	/	SYM
dpc-4596	213	5	j.cjca.2019.03.022	j.cjca.2019.03.022	PROPN
dpc-4596	213	6	.	.	PROPN
dpc-4596	213	7	20	20	NUM
dpc-4596	213	8	.	.	PUNCT
dpc-4596	214	1	schreiber	schreiber	PROPN
dpc-4596	214	2	kh	kh	PROPN
dpc-4596	214	3	,	,	PUNCT
dpc-4596	214	4	ortiz	ortiz	PROPN
dpc-4596	214	5	d	d	PROPN
dpc-4596	214	6	,	,	PUNCT
dpc-4596	214	7	academia	academia	PROPN
dpc-4596	214	8	ec	ec	PROPN
dpc-4596	214	9	,	,	PUNCT
dpc-4596	214	10	anies	anies	PROPN
dpc-4596	214	11	ac	ac	PROPN
dpc-4596	214	12	,	,	PUNCT
dpc-4596	214	13	liao	liao	PROPN
dpc-4596	214	14	cy	cy	PROPN
dpc-4596	214	15	,	,	PUNCT
dpc-4596	214	16	kennedy	kennedy	PROPN
dpc-4596	214	17	bk	bk	PROPN
dpc-4596	214	18	.	.	PUNCT
dpc-4596	214	19	rapamycin	rapamycin	PROPN
dpc-4596	214	20	-	-	PUNCT
dpc-4596	214	21	mediated	mediate	VERB
dpc-4596	214	22	mtorc2	mtorc2	NOUN
dpc-4596	214	23	inhibition	inhibition	NOUN
dpc-4596	214	24	is	be	AUX
dpc-4596	214	25	determined	determine	VERB
dpc-4596	214	26	by	by	ADP
dpc-4596	214	27	the	the	DET
dpc-4596	214	28	relative	relative	ADJ
dpc-4596	214	29	expression	expression	NOUN
dpc-4596	214	30	of	of	ADP
dpc-4596	214	31	fk506	fk506	NOUN
dpc-4596	214	32	-	-	PUNCT
dpc-4596	214	33	binding	bind	VERB
dpc-4596	214	34	proteins	protein	NOUN
dpc-4596	214	35	.	.	PUNCT
dpc-4596	215	1	aging	age	VERB
dpc-4596	215	2	cell	cell	NOUN
dpc-4596	215	3	.	.	PUNCT
dpc-4596	216	1	2015;14(2):265	2015;14(2):265	NOUN
dpc-4596	216	2	-	-	PUNCT
dpc-4596	216	3	73	73	NUM
dpc-4596	216	4	.	.	PUNCT
dpc-4596	217	1	doi	doi	NOUN
dpc-4596	217	2	:	:	PUNCT
dpc-4596	217	3	10.1111	10.1111	NUM
dpc-4596	217	4	/	/	SYM
dpc-4596	217	5	acel.12313	acel.12313	PROPN
dpc-4596	217	6	.	.	PROPN
dpc-4596	217	7	21	21	NUM
dpc-4596	217	8	.	.	PUNCT
dpc-4596	218	1	raychaudhuri	raychaudhuri	PROPN
dpc-4596	218	2	sk	sk	PROPN
dpc-4596	218	3	,	,	PUNCT
dpc-4596	218	4	raychaudhuri	raychaudhuri	PROPN
dpc-4596	218	5	sp	sp	PROPN
dpc-4596	218	6	.	.	PROPN
dpc-4596	218	7	mtor	mtor	PROPN
dpc-4596	218	8	signaling	signal	VERB
dpc-4596	218	9	cascade	cascade	NOUN
dpc-4596	218	10	in	in	ADP
dpc-4596	218	11	psoriatic	psoriatic	ADJ
dpc-4596	218	12	disease	disease	NOUN
dpc-4596	218	13	:	:	PUNCT
dpc-4596	218	14	double	double	ADJ
dpc-4596	218	15	kinase	kinase	PROPN
dpc-4596	218	16	mtor	mtor	PROPN
dpc-4596	218	17	inhibitor	inhibitor	PROPN
dpc-4596	218	18	a	a	DET
dpc-4596	218	19	novel	novel	ADJ
dpc-4596	218	20	therapeutic	therapeutic	ADJ
dpc-4596	218	21	target	target	NOUN
dpc-4596	218	22	.	.	PUNCT
dpc-4596	219	1	indian	indian	PROPN
dpc-4596	219	2	j	j	PROPN
dpc-4596	219	3	dermatol	dermatol	NOUN
dpc-4596	219	4	.	.	PUNCT
dpc-4596	220	1	2014;59(1):67	2014;59(1):67	NUM
dpc-4596	220	2	-	-	SYM
dpc-4596	220	3	70	70	NUM
dpc-4596	220	4	.	.	PUNCT
dpc-4596	221	1	doi	doi	NOUN
dpc-4596	221	2	:	:	PUNCT
dpc-4596	221	3	10.4103/0019	10.4103/0019	NUM
dpc-4596	221	4	-	-	SYM
dpc-4596	221	5	5154.123499	5154.123499	NUM
dpc-4596	221	6	.	.	PUNCT
dpc-4596	222	1	22	22	NUM
dpc-4596	222	2	.	.	PUNCT
dpc-4596	223	1	chamcheu	chamcheu	PROPN
dpc-4596	223	2	jc	jc	PROPN
dpc-4596	223	3	,	,	PUNCT
dpc-4596	223	4	adhami	adhami	PROPN
dpc-4596	223	5	vm	vm	PROPN
dpc-4596	223	6	,	,	PUNCT
dpc-4596	223	7	esnault	esnault	PROPN
dpc-4596	223	8	s	s	PART
dpc-4596	223	9	,	,	PUNCT
dpc-4596	223	10	et	et	PROPN
dpc-4596	223	11	al	al	PROPN
dpc-4596	223	12	.	.	PUNCT
dpc-4596	224	1	dual	dual	ADJ
dpc-4596	224	2	inhibition	inhibition	NOUN
dpc-4596	224	3	of	of	ADP
dpc-4596	224	4	pi3k	pi3k	PROPN
dpc-4596	224	5	/	/	SYM
dpc-4596	224	6	akt	akt	PROPN
dpc-4596	224	7	and	and	CCONJ
dpc-4596	224	8	mtor	mtor	PROPN
dpc-4596	224	9	by	by	ADP
dpc-4596	224	10	the	the	DET
dpc-4596	224	11	dietary	dietary	ADJ
dpc-4596	224	12	antioxidant	antioxidant	NOUN
dpc-4596	224	13	,	,	PUNCT
dpc-4596	224	14	delphinidin	delphinidin	NOUN
dpc-4596	224	15	,	,	PUNCT
dpc-4596	224	16	ameliorates	ameliorate	VERB
dpc-4596	224	17	psoriatic	psoriatic	ADJ
dpc-4596	224	18	features	feature	NOUN
dpc-4596	224	19	in	in	ADP
dpc-4596	224	20	vitro	vitro	NOUN
dpc-4596	224	21	and	and	CCONJ
dpc-4596	224	22	in	in	ADP
dpc-4596	224	23	an	an	DET
dpc-4596	224	24	imiquimod	imiquimod	ADJ
dpc-4596	224	25	induced	induced	ADJ
dpc-4596	224	26	psoriasis	psoriasis	NOUN
dpc-4596	224	27	-	-	PUNCT
dpc-4596	224	28	like	like	ADJ
dpc-4596	224	29	disease	disease	NOUN
dpc-4596	224	30	in	in	ADP
dpc-4596	224	31	mice	mouse	NOUN
dpc-4596	224	32	.	.	PUNCT
dpc-4596	225	1	antioxid	antioxid	VERB
dpc-4596	225	2	redox	redox	NOUN
dpc-4596	225	3	signal	signal	NOUN
dpc-4596	225	4	.	.	PUNCT
dpc-4596	226	1	2017;26(2):49	2017;26(2):49	X
dpc-4596	226	2	-	-	SYM
dpc-4596	226	3	69	69	NUM
dpc-4596	226	4	.	.	PUNCT
dpc-4596	227	1	doi	doi	NOUN
dpc-4596	227	2	:	:	PUNCT
dpc-4596	227	3	10.1089	10.1089	NUM
dpc-4596	227	4	/	/	SYM
dpc-4596	227	5	ars.2016.6769	ars.2016.6769	PROPN
dpc-4596	227	6	.	.	PUNCT
dpc-4596	228	1	23	23	NUM
dpc-4596	228	2	.	.	PUNCT
dpc-4596	229	1	roy	roy	PROPN
dpc-4596	229	2	t	t	PROPN
dpc-4596	229	3	,	,	PUNCT
dpc-4596	229	4	banang	banang	NOUN
dpc-4596	229	5	-	-	PUNCT
dpc-4596	229	6	mbeumi	mbeumi	NOUN
dpc-4596	229	7	s	s	PROPN
dpc-4596	229	8	,	,	PUNCT
dpc-4596	229	9	boateng	boateng	PROPN
dpc-4596	229	10	st	st	PROPN
dpc-4596	229	11	,	,	PUNCT
dpc-4596	229	12	et	et	PROPN
dpc-4596	229	13	al	al	PROPN
dpc-4596	229	14	.	.	PUNCT
dpc-4596	230	1	dual	dual	ADJ
dpc-4596	230	2	targeting	targeting	NOUN
dpc-4596	230	3	of	of	ADP
dpc-4596	230	4	mtor	mtor	PROPN
dpc-4596	230	5	/	/	SYM
dpc-4596	230	6	il-17a	il-17a	PROPN
dpc-4596	230	7	and	and	CCONJ
dpc-4596	230	8	autophagy	autophagy	VERB
dpc-4596	230	9	by	by	ADP
dpc-4596	230	10	fisetin	fisetin	NOUN
dpc-4596	230	11	alleviates	alleviate	VERB
dpc-4596	230	12	psoriasis	psoriasis	NOUN
dpc-4596	230	13	-	-	PUNCT
dpc-4596	230	14	like	like	ADJ
dpc-4596	230	15	skin	skin	NOUN
dpc-4596	230	16	inflammation	inflammation	NOUN
dpc-4596	230	17	.	.	PUNCT
dpc-4596	231	1	front	front	ADJ
dpc-4596	231	2	immunol	immunol	NOUN
dpc-4596	231	3	.	.	PUNCT
dpc-4596	232	1	2022;13:1075804	2022;13:1075804	NUM
dpc-4596	232	2	.	.	PUNCT
dpc-4596	232	3	doi	doi	NOUN
dpc-4596	232	4	:	:	PUNCT
dpc-4596	232	5	10.3389	10.3389	NUM
dpc-4596	232	6	/	/	SYM
dpc-4596	232	7	fimmu.2022.1075804	fimmu.2022.1075804	NOUN
dpc-4596	232	8	.	.	PUNCT
dpc-4596	233	1	24	24	NUM
dpc-4596	233	2	.	.	PUNCT
dpc-4596	234	1	liu	liu	PROPN
dpc-4596	234	2	z	z	PROPN
dpc-4596	234	3	,	,	PUNCT
dpc-4596	234	4	fan	fan	PROPN
dpc-4596	234	5	y	y	PROPN
dpc-4596	234	6	,	,	PUNCT
dpc-4596	234	7	zhang	zhang	PROPN
dpc-4596	234	8	z	z	PROPN
dpc-4596	234	9	,	,	PUNCT
dpc-4596	234	10	et	et	PROPN
dpc-4596	234	11	al	al	PROPN
dpc-4596	234	12	.	.	PROPN
dpc-4596	234	13	mtor	mtor	PROPN
dpc-4596	234	14	in	in	ADP
dpc-4596	234	15	the	the	DET
dpc-4596	234	16	mechanisms	mechanism	NOUN
dpc-4596	234	17	of	of	ADP
dpc-4596	234	18	atherosclerosis	atherosclerosis	NOUN
dpc-4596	234	19	and	and	CCONJ
dpc-4596	234	20	cardiovascular	cardiovascular	ADJ
dpc-4596	234	21	disease	disease	NOUN
dpc-4596	234	22	.	.	PUNCT
dpc-4596	235	1	discov	discov	PROPN
dpc-4596	235	2	med	med	PROPN
dpc-4596	235	3	.	.	PUNCT
dpc-4596	235	4	2021	2021	NUM
dpc-4596	235	5	;	;	PUNCT
dpc-4596	235	6	31(164):129	31(164):129	NUM
dpc-4596	235	7	-	-	SYM
dpc-4596	235	8	40	40	NUM
dpc-4596	235	9	.	.	PUNCT
dpc-4596	235	10	25	25	NUM
dpc-4596	235	11	.	.	PUNCT
dpc-4596	236	1	sarandi	sarandi	PROPN
dpc-4596	236	2	e	e	PROPN
dpc-4596	236	3	,	,	PUNCT
dpc-4596	236	4	krueger	krueger	PROPN
dpc-4596	236	5	-	-	PUNCT
dpc-4596	236	6	krasagakis	krasagakis	PROPN
dpc-4596	236	7	s	s	PROPN
dpc-4596	236	8	,	,	PUNCT
dpc-4596	236	9	tsoukalas	tsoukalas	PROPN
dpc-4596	236	10	d	d	PROPN
dpc-4596	236	11	,	,	PUNCT
dpc-4596	236	12	et	et	PROPN
dpc-4596	236	13	al	al	PROPN
dpc-4596	236	14	.	.	PUNCT
dpc-4596	236	15	psoriasis	psoriasis	NOUN
dpc-4596	236	16	immunometabolism	immunometabolism	NOUN
dpc-4596	236	17	:	:	PUNCT
dpc-4596	236	18	progress	progress	NOUN
dpc-4596	236	19	on	on	ADP
dpc-4596	236	20	metabolic	metabolic	NOUN
dpc-4596	236	21	biomarkers	biomarker	NOUN
dpc-4596	236	22	and	and	CCONJ
dpc-4596	236	23	targeted	target	VERB
dpc-4596	236	24	therapy	therapy	NOUN
dpc-4596	236	25	.	.	PUNCT
dpc-4596	237	1	front	front	NOUN
dpc-4596	237	2	mol	mol	ADP
dpc-4596	237	3	biosci	biosci	PROPN
dpc-4596	237	4	.	.	PUNCT
dpc-4596	238	1	2023;10:1201912	2023;10:1201912	NUM
dpc-4596	238	2	.	.	PUNCT
dpc-4596	238	3	doi	doi	NOUN
dpc-4596	238	4	:	:	PUNCT
dpc-4596	238	5	10.3389	10.3389	NUM
dpc-4596	238	6	/fmolb.2023.1201912	/fmolb.2023.1201912	NOUN
dpc-4596	238	7	.	.	PUNCT
dpc-4596	239	1	26	26	NUM
dpc-4596	239	2	.	.	PUNCT
dpc-4596	240	1	loyola	loyola	PROPN
dpc-4596	240	2	k	k	PROPN
dpc-4596	240	3	,	,	PUNCT
dpc-4596	240	4	karsulovic	karsulovic	PROPN
dpc-4596	240	5	c	c	PROPN
dpc-4596	240	6	,	,	PUNCT
dpc-4596	240	7	cabrera	cabrera	PROPN
dpc-4596	240	8	r	r	PROPN
dpc-4596	240	9	,	,	PUNCT
dpc-4596	240	10	perez	perez	PROPN
dpc-4596	240	11	c	c	PROPN
dpc-4596	240	12	,	,	PUNCT
dpc-4596	240	13	hojman	hojman	PROPN
dpc-4596	240	14	l.	l.	PROPN
dpc-4596	240	15	new	new	PROPN
dpc-4596	240	16	markers	marker	NOUN
dpc-4596	240	17	for	for	ADP
dpc-4596	240	18	cardiovascular	cardiovascular	ADJ
dpc-4596	240	19	disease	disease	NOUN
dpc-4596	240	20	in	in	ADP
dpc-4596	240	21	psoriatic	psoriatic	ADJ
dpc-4596	240	22	patients	patient	NOUN
dpc-4596	240	23	:	:	PUNCT
dpc-4596	240	24	preliminary	preliminary	ADJ
dpc-4596	240	25	study	study	NOUN
dpc-4596	240	26	on	on	ADP
dpc-4596	240	27	monocyte	monocyte	NOUN
dpc-4596	240	28	phenotype	phenotype	NOUN
dpc-4596	240	29	,	,	PUNCT
dpc-4596	240	30	adamts7	adamts7	PROPN
dpc-4596	240	31	,	,	PUNCT
dpc-4596	240	32	and	and	CCONJ
dpc-4596	240	33	mtor	mtor	PROPN
dpc-4596	240	34	activity	activity	NOUN
dpc-4596	240	35	.	.	PUNCT
dpc-4596	241	1	metabolites	metabolite	NOUN
dpc-4596	241	2	.	.	PUNCT
dpc-4596	242	1	2023;13(1	2023;13(1	NUM
dpc-4596	242	2	)	)	PUNCT
dpc-4596	242	3	.	.	PUNCT
dpc-4596	243	1	doi	doi	NOUN
dpc-4596	243	2	:	:	PUNCT
dpc-4596	243	3	10.3390	10.3390	NUM
dpc-4596	243	4	/	/	SYM
dpc-4596	243	5	metabo	metabo	NOUN
dpc-4596	243	6	13010116	13010116	NUM
dpc-4596	243	7	.	.	PUNCT
dpc-4596	244	1	epidermal	epidermal	ADJ
dpc-4596	244	2	barrier	barrier	NOUN
dpc-4596	244	3	formation	formation	NOUN
dpc-4596	244	4	.	.	PUNCT
dpc-4596	245	1	nat	nat	PROPN
dpc-4596	245	2	commun	commun	PROPN
dpc-4596	245	3	.	.	PUNCT
dpc-4596	246	1	2016;7:13226	2016;7:13226	NUM
dpc-4596	246	2	.	.	PUNCT
dpc-4596	247	1	doi	doi	NOUN
dpc-4596	247	2	:	:	PUNCT
dpc-4596	247	3	10.1038	10.1038	NUM
dpc-4596	247	4	/	/	SYM
dpc-4596	247	5	ncomms13226	ncomms13226	NOUN
dpc-4596	247	6	.	.	PUNCT
dpc-4596	248	1	8	8	NUM
dpc-4596	248	2	.	.	PUNCT
dpc-4596	249	1	karagianni	karagianni	PROPN
dpc-4596	249	2	f	f	PROPN
dpc-4596	249	3	,	,	PUNCT
dpc-4596	249	4	pavlidis	pavlidi	NOUN
dpc-4596	249	5	a	a	PRON
dpc-4596	249	6	,	,	PUNCT
dpc-4596	249	7	malakou	malakou	PROPN
dpc-4596	249	8	ls	ls	PROPN
dpc-4596	249	9	,	,	PUNCT
dpc-4596	249	10	piperi	piperi	NOUN
dpc-4596	249	11	c	c	NOUN
dpc-4596	249	12	,	,	PUNCT
dpc-4596	249	13	papadavid	papadavid	PROPN
dpc-4596	249	14	e.	e.	PROPN
dpc-4596	249	15	predominant	predominant	ADJ
dpc-4596	249	16	role	role	NOUN
dpc-4596	249	17	of	of	ADP
dpc-4596	249	18	mtor	mtor	NOUN
dpc-4596	249	19	signaling	signal	VERB
dpc-4596	249	20	in	in	ADP
dpc-4596	249	21	skin	skin	NOUN
dpc-4596	249	22	diseases	disease	NOUN
dpc-4596	249	23	with	with	ADP
dpc-4596	249	24	therapeutic	therapeutic	ADJ
dpc-4596	249	25	potential	potential	NOUN
dpc-4596	249	26	.	.	PUNCT
dpc-4596	250	1	int	int	PROPN
dpc-4596	250	2	j	j	PROPN
dpc-4596	250	3	mol	mol	ADP
dpc-4596	250	4	sci	sci	PROPN
dpc-4596	250	5	.	.	PUNCT
dpc-4596	250	6	2022;23(3	2022;23(3	NUM
dpc-4596	250	7	)	)	PUNCT
dpc-4596	250	8	.	.	PUNCT
dpc-4596	251	1	doi	doi	NOUN
dpc-4596	251	2	:	:	PUNCT
dpc-4596	251	3	10.3390	10.3390	NUM
dpc-4596	251	4	/ijms23031693	/ijms23031693	PUNCT
dpc-4596	251	5	.	.	PUNCT
dpc-4596	252	1	9	9	NUM
dpc-4596	252	2	.	.	X
dpc-4596	252	3	buerger	buerger	PROPN
dpc-4596	252	4	c	c	NOUN
dpc-4596	252	5	,	,	PUNCT
dpc-4596	252	6	malisiewicz	malisiewicz	PROPN
dpc-4596	252	7	b	b	NOUN
dpc-4596	252	8	,	,	PUNCT
dpc-4596	252	9	eiser	eiser	ADJ
dpc-4596	252	10	a	a	NOUN
dpc-4596	252	11	,	,	PUNCT
dpc-4596	252	12	hardt	hardt	PROPN
dpc-4596	252	13	k	k	PROPN
dpc-4596	252	14	,	,	PUNCT
dpc-4596	252	15	boehncke	boehncke	PROPN
dpc-4596	252	16	wh	wh	PROPN
dpc-4596	252	17	.	.	PUNCT
dpc-4596	253	1	mammalian	mammalian	ADJ
dpc-4596	253	2	target	target	NOUN
dpc-4596	253	3	of	of	ADP
dpc-4596	253	4	rapamycin	rapamycin	NOUN
dpc-4596	253	5	and	and	CCONJ
dpc-4596	253	6	its	its	PRON
dpc-4596	253	7	downstream	downstream	ADJ
dpc-4596	253	8	signalling	signal	VERB
dpc-4596	253	9	components	component	NOUN
dpc-4596	253	10	are	be	AUX
dpc-4596	253	11	activated	activate	VERB
dpc-4596	253	12	in	in	ADP
dpc-4596	253	13	psoriatic	psoriatic	ADJ
dpc-4596	253	14	skin	skin	NOUN
dpc-4596	253	15	.	.	PUNCT
dpc-4596	254	1	br	br	PROPN
dpc-4596	254	2	j	j	PROPN
dpc-4596	254	3	dermatol	dermatol	NOUN
dpc-4596	254	4	.	.	PUNCT
dpc-4596	255	1	2013;169(1):156	2013;169(1):156	NUM
dpc-4596	255	2	-	-	SYM
dpc-4596	255	3	9	9	NUM
dpc-4596	255	4	.	.	PUNCT
dpc-4596	255	5	doi	doi	NOUN
dpc-4596	255	6	:	:	PUNCT
dpc-4596	255	7	10.1111	10.1111	NUM
dpc-4596	255	8	/	/	SYM
dpc-4596	255	9	bjd.12271	bjd.12271	NOUN
dpc-4596	255	10	.	.	PUNCT
dpc-4596	256	1	10	10	NUM
dpc-4596	256	2	.	.	PUNCT
dpc-4596	257	1	buerger	buerger	PROPN
dpc-4596	257	2	c	c	PROPN
dpc-4596	257	3	,	,	PUNCT
dpc-4596	257	4	shirsath	shirsath	NOUN
dpc-4596	257	5	n	n	CCONJ
dpc-4596	257	6	,	,	PUNCT
dpc-4596	257	7	lang	lang	PROPN
dpc-4596	257	8	v	v	PROPN
dpc-4596	257	9	,	,	PUNCT
dpc-4596	257	10	et	et	PROPN
dpc-4596	257	11	al	al	PROPN
dpc-4596	257	12	.	.	PUNCT
dpc-4596	258	1	inflammation	inflammation	PROPN
dpc-4596	258	2	dependent	dependent	ADJ
dpc-4596	259	1	mtorc1	mtorc1	NOUN
dpc-4596	259	2	signaling	signal	VERB
dpc-4596	259	3	interferes	interfere	VERB
dpc-4596	259	4	with	with	ADP
dpc-4596	259	5	the	the	DET
dpc-4596	259	6	switch	switch	NOUN
dpc-4596	259	7	from	from	ADP
dpc-4596	259	8	keratinocyte	keratinocyte	NOUN
dpc-4596	259	9	proliferation	proliferation	NOUN
dpc-4596	259	10	to	to	ADP
dpc-4596	259	11	differentiation	differentiation	NOUN
dpc-4596	259	12	.	.	PUNCT
dpc-4596	260	1	plos	plos	PROPN
dpc-4596	260	2	one	one	NUM
dpc-4596	260	3	.	.	PUNCT
dpc-4596	261	1	2017;12(7):e0180853	2017;12(7):e0180853	X
dpc-4596	261	2	.	.	PUNCT
dpc-4596	262	1	doi	doi	NOUN
dpc-4596	262	2	:	:	PUNCT
dpc-4596	262	3	10.1371	10.1371	NUM
dpc-4596	262	4	/	/	SYM
dpc-4596	262	5	journal.pone.0180853	journal.pone.0180853	NOUN
dpc-4596	262	6	.	.	PROPN
dpc-4596	262	7	11	11	NUM
dpc-4596	262	8	.	.	PUNCT
dpc-4596	263	1	ochaion	ochaion	NOUN
dpc-4596	263	2	a	a	DET
dpc-4596	263	3	,	,	PUNCT
dpc-4596	263	4	bar	bar	NOUN
dpc-4596	263	5	-	-	PUNCT
dpc-4596	263	6	yehuda	yehuda	NOUN
dpc-4596	263	7	s	s	PART
dpc-4596	263	8	,	,	PUNCT
dpc-4596	263	9	cohen	cohen	PROPN
dpc-4596	263	10	s	s	PROPN
dpc-4596	263	11	,	,	PUNCT
dpc-4596	263	12	et	et	PROPN
dpc-4596	263	13	al	al	PROPN
dpc-4596	263	14	.	.	PUNCT
dpc-4596	264	1	the	the	DET
dpc-4596	264	2	antiinflammatory	antiinflammatory	NOUN
dpc-4596	264	3	target	target	NOUN
dpc-4596	264	4	a(3	a(3	NOUN
dpc-4596	264	5	)	)	PUNCT
dpc-4596	264	6	adenosine	adenosine	NOUN
dpc-4596	264	7	receptor	receptor	NOUN
dpc-4596	264	8	is	be	AUX
dpc-4596	264	9	over	over	ADV
dpc-4596	264	10	-	-	PUNCT
dpc-4596	264	11	expressed	express	VERB
dpc-4596	264	12	in	in	ADP
dpc-4596	264	13	rheumatoid	rheumatoid	NOUN
dpc-4596	264	14	arthritis	arthritis	NOUN
dpc-4596	264	15	,	,	PUNCT
dpc-4596	264	16	psoriasis	psoriasis	NOUN
dpc-4596	264	17	and	and	CCONJ
dpc-4596	264	18	crohn	crohn	PROPN
dpc-4596	264	19	’s	’s	PART
dpc-4596	264	20	disease	disease	NOUN
dpc-4596	264	21	.	.	PUNCT
dpc-4596	265	1	cell	cell	NOUN
dpc-4596	265	2	immunol	immunol	NOUN
dpc-4596	265	3	.	.	PUNCT
dpc-4596	266	1	2009;258(2):115	2009;258(2):115	NUM
dpc-4596	266	2	-	-	SYM
dpc-4596	266	3	22	22	NUM
dpc-4596	266	4	.	.	PUNCT
dpc-4596	267	1	doi	doi	NOUN
dpc-4596	267	2	:	:	PUNCT
dpc-4596	267	3	10.1016	10.1016	NUM
dpc-4596	267	4	/	/	SYM
dpc-4596	267	5	j.cellimm.2009.03.020	j.cellimm.2009.03.020	PROPN
dpc-4596	267	6	.	.	PROPN
dpc-4596	268	1	12	12	NUM
dpc-4596	268	2	.	.	PUNCT
dpc-4596	269	1	cao	cao	PROPN
dpc-4596	269	2	w	w	PROPN
dpc-4596	269	3	,	,	PUNCT
dpc-4596	269	4	manicassamy	manicassamy	PROPN
dpc-4596	269	5	s	s	PROPN
dpc-4596	269	6	,	,	PUNCT
dpc-4596	269	7	tang	tang	PROPN
dpc-4596	269	8	h	h	PROPN
dpc-4596	269	9	,	,	PUNCT
dpc-4596	269	10	et	et	PROPN
dpc-4596	269	11	al	al	PROPN
dpc-4596	269	12	.	.	PUNCT
dpc-4596	269	13	toll	toll	NOUN
dpc-4596	269	14	-	-	PUNCT
dpc-4596	269	15	like	like	ADJ
dpc-4596	269	16	receptormediated	receptormediate	VERB
dpc-4596	269	17	induction	induction	NOUN
dpc-4596	269	18	of	of	ADP
dpc-4596	269	19	type	type	NOUN
dpc-4596	269	20	i	i	PRON
dpc-4596	269	21	interferon	interferon	ADJ
dpc-4596	269	22	in	in	ADP
dpc-4596	269	23	plasmacytoid	plasmacytoid	NOUN
dpc-4596	269	24	dendritic	dendritic	ADJ
dpc-4596	269	25	cells	cell	NOUN
dpc-4596	269	26	requires	require	VERB
dpc-4596	269	27	the	the	DET
dpc-4596	269	28	rapamycin	rapamycin	NOUN
dpc-4596	269	29	-	-	PUNCT
dpc-4596	269	30	sensitive	sensitive	ADJ
dpc-4596	269	31	pi(3)k	pi(3)k	NOUN
dpc-4596	269	32	-	-	PUNCT
dpc-4596	269	33	mtor	mtor	NOUN
dpc-4596	269	34	-	-	PUNCT
dpc-4596	269	35	p70s6k	p70s6k	PROPN
dpc-4596	269	36	pathway	pathway	NOUN
dpc-4596	269	37	.	.	PUNCT
dpc-4596	270	1	nat	nat	PROPN
dpc-4596	270	2	immunol	immunol	NOUN
dpc-4596	270	3	.	.	PUNCT
dpc-4596	271	1	2008;9(10):1157	2008;9(10):1157	NUM
dpc-4596	271	2	-	-	SYM
dpc-4596	271	3	64	64	NUM
dpc-4596	271	4	.	.	PUNCT
dpc-4596	272	1	doi	doi	NOUN
dpc-4596	272	2	:	:	PUNCT
dpc-4596	272	3	10.1038	10.1038	NUM
dpc-4596	272	4	/	/	SYM
dpc-4596	272	5	ni.1645	ni.1645	PROPN
dpc-4596	272	6	.	.	PROPN
dpc-4596	273	1	13	13	NUM
dpc-4596	273	2	.	.	PUNCT
dpc-4596	274	1	fan	fan	PROPN
dpc-4596	274	2	x	x	PROPN
dpc-4596	274	3	,	,	PUNCT
dpc-4596	274	4	shen	shen	PROPN
dpc-4596	275	1	z	z	PROPN
dpc-4596	275	2	,	,	PUNCT
dpc-4596	275	3	wang	wang	PROPN
dpc-4596	275	4	g	g	PROPN
dpc-4596	275	5	,	,	PUNCT
dpc-4596	275	6	yufeng	yufeng	PROPN
dpc-4596	275	7	l.	l.	PROPN
dpc-4596	275	8	is	be	AUX
dpc-4596	275	9	ccr7	ccr7	VERB
dpc-4596	275	10	a	a	DET
dpc-4596	275	11	potential	potential	ADJ
dpc-4596	275	12	target	target	NOUN
dpc-4596	275	13	for	for	ADP
dpc-4596	275	14	biologic	biologic	NOUN
dpc-4596	275	15	therapy	therapy	NOUN
dpc-4596	275	16	in	in	ADP
dpc-4596	275	17	psoriasis	psoriasis	NOUN
dpc-4596	275	18	?	?	PUNCT
dpc-4596	276	1	increased	increase	VERB
dpc-4596	276	2	expression	expression	NOUN
dpc-4596	276	3	of	of	ADP
dpc-4596	276	4	ccr7	ccr7	NOUN
dpc-4596	276	5	in	in	ADP
dpc-4596	276	6	psoriasis	psoriasis	NOUN
dpc-4596	276	7	vulgaris	vulgaris	NOUN
dpc-4596	276	8	.	.	PUNCT
dpc-4596	277	1	indian	indian	PROPN
dpc-4596	277	2	j	j	PROPN
dpc-4596	277	3	dermatol	dermatol	PROPN
dpc-4596	277	4	venereol	venereol	ADJ
dpc-4596	277	5	leprol	leprol	PROPN
dpc-4596	277	6	.	.	PUNCT
dpc-4596	278	1	2008;74(5):550	2008;74(5):550	NOUN
dpc-4596	278	2	.	.	PUNCT
dpc-4596	279	1	doi	doi	NOUN
dpc-4596	279	2	:	:	PUNCT
dpc-4596	279	3	10.4103/0378	10.4103/0378	NUM
dpc-4596	279	4	-	-	PUNCT
dpc-4596	279	5	6323.44338	6323.44338	NOUN
dpc-4596	279	6	.	.	PUNCT
dpc-4596	280	1	14	14	NUM
dpc-4596	280	2	.	.	PUNCT
dpc-4596	280	3	kuwabara	kuwabara	PROPN
dpc-4596	280	4	t	t	PROPN
dpc-4596	280	5	,	,	PUNCT
dpc-4596	280	6	tanaka	tanaka	PROPN
dpc-4596	280	7	y	y	PROPN
dpc-4596	280	8	,	,	PUNCT
dpc-4596	280	9	ishikawa	ishikawa	PROPN
dpc-4596	280	10	f	f	PROPN
dpc-4596	280	11	,	,	PUNCT
dpc-4596	280	12	kondo	kondo	PROPN
dpc-4596	280	13	m	m	PROPN
dpc-4596	280	14	,	,	PUNCT
dpc-4596	280	15	sekiya	sekiya	ADJ
dpc-4596	280	16	h	h	NOUN
dpc-4596	280	17	,	,	PUNCT
dpc-4596	280	18	kakiuchi	kakiuchi	PROPN
dpc-4596	280	19	t.	t.	PROPN
dpc-4596	280	20	ccr7	ccr7	PROPN
dpc-4596	280	21	ligands	ligand	VERB
dpc-4596	280	22	up	up	ADP
dpc-4596	280	23	-	-	PUNCT
dpc-4596	280	24	regulate	regulate	VERB
dpc-4596	280	25	il-23	il-23	NOUN
dpc-4596	280	26	through	through	ADP
dpc-4596	280	27	pi3kinase	pi3kinase	NOUN
dpc-4596	280	28	and	and	CCONJ
dpc-4596	280	29	nf	nf	NOUN
dpc-4596	280	30	-	-	PUNCT
dpc-4596	280	31	kappa	kappa	NOUN
dpc-4596	280	32	b	b	PROPN
dpc-4596	280	33	pathway	pathway	NOUN
dpc-4596	280	34	in	in	ADP
dpc-4596	280	35	dendritic	dendritic	ADJ
dpc-4596	280	36	cells	cell	NOUN
dpc-4596	280	37	.	.	PUNCT
dpc-4596	281	1	j	j	PROPN
dpc-4596	281	2	leukoc	leukoc	VERB
dpc-4596	281	3	biol	biol	PROPN
dpc-4596	281	4	.	.	PUNCT
dpc-4596	282	1	2012;92(2):309	2012;92(2):309	NUM
dpc-4596	282	2	-	-	SYM
dpc-4596	282	3	18	18	NUM
dpc-4596	282	4	.	.	PUNCT
dpc-4596	282	5	 	 	SPACE
dpc-4596	282	6	doi	doi	NOUN
dpc-4596	282	7	:	:	PUNCT
dpc-4596	282	8	10.1189	10.1189	NUM
dpc-4596	282	9	/	/	SYM
dpc-4596	282	10	jlb.0811415	jlb.0811415	NUM
dpc-4596	282	11	.	.	PUNCT
dpc-4596	283	1	15	15	NUM
dpc-4596	283	2	.	.	X
dpc-4596	283	3	perl	perl	NOUN
dpc-4596	283	4	a.	a.	NOUN
dpc-4596	283	5	activation	activation	NOUN
dpc-4596	283	6	of	of	ADP
dpc-4596	283	7	mtor	mtor	NOUN
dpc-4596	283	8	(	(	PUNCT
dpc-4596	283	9	mechanistic	mechanistic	ADJ
dpc-4596	283	10	target	target	NOUN
dpc-4596	283	11	of	of	ADP
dpc-4596	283	12	rapamycin	rapamycin	NOUN
dpc-4596	283	13	)	)	PUNCT
dpc-4596	283	14	in	in	ADP
dpc-4596	283	15	rheumatic	rheumatic	ADJ
dpc-4596	283	16	diseases	disease	NOUN
dpc-4596	283	17	.	.	PUNCT
dpc-4596	284	1	nat	nat	PROPN
dpc-4596	284	2	rev	rev	PROPN
dpc-4596	284	3	rheumatol	rheumatol	NOUN
dpc-4596	284	4	.	.	PUNCT
dpc-4596	285	1	2016;12(3):169	2016;12(3):169	NUM
dpc-4596	285	2	-	-	SYM
dpc-4596	285	3	82	82	NUM
dpc-4596	285	4	.	.	PUNCT
dpc-4596	285	5	doi	doi	NOUN
dpc-4596	285	6	:	:	PUNCT
dpc-4596	285	7	10.1038	10.1038	NUM
dpc-4596	285	8	/	/	SYM
dpc-4596	285	9	nrrheum.2015.172	nrrheum.2015.172	PROPN
dpc-4596	285	10	.	.	PUNCT
dpc-4596	286	1	16	16	NUM
dpc-4596	286	2	.	.	PUNCT
dpc-4596	287	1	mitra	mitra	PROPN
dpc-4596	287	2	a	a	PRON
dpc-4596	287	3	,	,	PUNCT
dpc-4596	287	4	raychaudhuri	raychaudhuri	PROPN
dpc-4596	287	5	sk	sk	NOUN
dpc-4596	287	6	,	,	PUNCT
dpc-4596	287	7	raychaudhuri	raychaudhuri	PROPN
dpc-4596	287	8	sp	sp	PROPN
dpc-4596	287	9	.	.	PROPN
dpc-4596	287	10	il-22	il-22	PART
dpc-4596	287	11	induced	induce	VERB
dpc-4596	287	12	cell	cell	NOUN
dpc-4596	287	13	proliferation	proliferation	NOUN
dpc-4596	287	14	is	be	AUX
dpc-4596	287	15	regulated	regulate	VERB
dpc-4596	287	16	by	by	ADP
dpc-4596	287	17	pi3k	pi3k	PROPN
dpc-4596	287	18	/	/	SYM
dpc-4596	287	19	akt	akt	PROPN
dpc-4596	287	20	/	/	SYM
dpc-4596	287	21	mtor	mtor	PROPN
dpc-4596	287	22	signaling	signal	VERB
dpc-4596	287	23	cascade	cascade	NOUN
dpc-4596	287	24	.	.	PUNCT
dpc-4596	288	1	cytokine	cytokine	NOUN
dpc-4596	288	2	.	.	PUNCT
dpc-4596	289	1	2012;60(1):38	2012;60(1):38	NUM
dpc-4596	289	2	-	-	SYM
dpc-4596	289	3	42	42	NUM
dpc-4596	289	4	.	.	PUNCT
dpc-4596	290	1	doi	doi	NOUN
dpc-4596	290	2	:	:	PUNCT
dpc-4596	290	3	10.1016	10.1016	NUM
dpc-4596	290	4	/	/	SYM
dpc-4596	290	5	j.cyto.2012.06.316	j.cyto.2012.06.316	PROPN
dpc-4596	290	6	.	.	PROPN
dpc-4596	290	7	17	17	NUM
dpc-4596	290	8	.	.	PUNCT
dpc-4596	291	1	huang	huang	PROPN
dpc-4596	291	2	t	t	PROPN
dpc-4596	291	3	,	,	PUNCT
dpc-4596	291	4	lin	lin	PROPN
dpc-4596	291	5	x	x	PROPN
dpc-4596	291	6	,	,	PUNCT
dpc-4596	291	7	meng	meng	PROPN
dpc-4596	291	8	x	x	PROPN
dpc-4596	291	9	,	,	PUNCT
dpc-4596	291	10	lin	lin	PROPN
dpc-4596	291	11	m.	m.	NOUN
dpc-4596	292	1	phosphoinositide-3	phosphoinositide-3	NUM
dpc-4596	292	2	kinase/	kinase/	NOUN
dpc-4596	292	3	protein	protein	NOUN
dpc-4596	292	4	kinase	kinase	NOUN
dpc-4596	292	5	-	-	PUNCT
dpc-4596	292	6	b	b	NOUN
dpc-4596	292	7	/	/	SYM
dpc-4596	292	8	mammalian	mammalian	ADJ
dpc-4596	292	9	target	target	NOUN
dpc-4596	292	10	of	of	ADP
dpc-4596	292	11	rapamycin	rapamycin	NOUN
dpc-4596	292	12	pathway	pathway	NOUN
dpc-4596	292	13	in	in	ADP