id	sid	tid	token	lemma	pos
dpc-4871	1	1	dermatology	dermatology	NOUN
dpc-4871	1	2	:	:	PUNCT
dpc-4871	1	3	practical	practical	ADJ
dpc-4871	1	4	and	and	CCONJ
dpc-4871	1	5	conceptual	conceptual	ADJ
dpc-4871	1	6	original	original	ADJ
dpc-4871	1	7	article	article	NOUN
dpc-4871	1	8	|	|	ADV
dpc-4871	1	9	dermatol	dermatol	ADJ
dpc-4871	1	10	pract	pract	NOUN
dpc-4871	1	11	concept	concept	NOUN
dpc-4871	1	12	.	.	PUNCT
dpc-4871	2	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	2	2	1	1	NUM
dpc-4871	2	3	real	real	ADJ
dpc-4871	2	4	-	-	PUNCT
dpc-4871	2	5	life	life	NOUN
dpc-4871	2	6	analysis	analysis	NOUN
dpc-4871	2	7	of	of	ADP
dpc-4871	2	8	therapeutic	therapeutic	ADJ
dpc-4871	2	9	management	management	NOUN
dpc-4871	2	10	and	and	CCONJ
dpc-4871	2	11	its	its	PRON
dpc-4871	2	12	correlation	correlation	NOUN
dpc-4871	2	13	with	with	ADP
dpc-4871	2	14	the	the	DET
dpc-4871	2	15	dermatology	dermatology	NOUN
dpc-4871	2	16	life	life	NOUN
dpc-4871	2	17	quality	quality	NOUN
dpc-4871	2	18	index	index	NOUN
dpc-4871	2	19	score	score	NOUN
dpc-4871	2	20	in	in	ADP
dpc-4871	2	21	108	108	NUM
dpc-4871	2	22	patients	patient	NOUN
dpc-4871	2	23	with	with	ADP
dpc-4871	2	24	pustular	pustular	ADJ
dpc-4871	2	25	psoriasis	psoriasis	NOUN
dpc-4871	2	26	:	:	PUNCT
dpc-4871	2	27	an	an	DET
dpc-4871	2	28	italian	italian	ADJ
dpc-4871	2	29	monocenter	monocenter	NOUN
dpc-4871	2	30	study	study	NOUN
dpc-4871	2	31	dario	dario	PROPN
dpc-4871	2	32	buononato1	buononato1	PROPN
dpc-4871	2	33	,	,	PUNCT
dpc-4871	2	34	emanuele	emanuele	PROPN
dpc-4871	2	35	scala2,3	scala2,3	PROPN
dpc-4871	2	36	,	,	PUNCT
dpc-4871	2	37	pierfrancesco	pierfrancesco	PROPN
dpc-4871	2	38	benvenuto1	benvenuto1	PROPN
dpc-4871	2	39	,	,	PUNCT
dpc-4871	2	40	stefano	stefano	PROPN
dpc-4871	2	41	caccavale1	caccavale1	PROPN
dpc-4871	2	42	,	,	PUNCT
dpc-4871	2	43	eugenia	eugenia	PROPN
dpc-4871	2	44	veronica	veronica	PROPN
dpc-4871	2	45	di	di	PROPN
dpc-4871	2	46	brizzi1	brizzi1	PROPN
dpc-4871	2	47	,	,	PUNCT
dpc-4871	2	48	roberta	roberta	PROPN
dpc-4871	2	49	di	di	PROPN
dpc-4871	2	50	caprio1	caprio1	PROPN
dpc-4871	2	51	,	,	PUNCT
dpc-4871	2	52	giuseppe	giuseppe	PROPN
dpc-4871	2	53	argenziano1	argenziano1	PROPN
dpc-4871	2	54	,	,	PUNCT
dpc-4871	2	55	anna	anna	PROPN
dpc-4871	2	56	balato1	balato1	NOUN
dpc-4871	2	57	1	1	NUM
dpc-4871	2	58	unit	unit	NOUN
dpc-4871	2	59	of	of	ADP
dpc-4871	2	60	dermatology	dermatology	NOUN
dpc-4871	2	61	,	,	PUNCT
dpc-4871	2	62	university	university	PROPN
dpc-4871	2	63	of	of	ADP
dpc-4871	2	64	campania	campania	PROPN
dpc-4871	2	65	“	"	PUNCT
dpc-4871	2	66	luigi	luigi	PROPN
dpc-4871	2	67	vanvitelli	vanvitelli	PROPN
dpc-4871	2	68	”	"	PUNCT
dpc-4871	2	69	,	,	PUNCT
dpc-4871	2	70	naples	naples	PROPN
dpc-4871	2	71	,	,	PUNCT
dpc-4871	2	72	italy	italy	PROPN
dpc-4871	2	73	2	2	NUM
dpc-4871	2	74	division	division	NOUN
dpc-4871	2	75	of	of	ADP
dpc-4871	2	76	dermatology	dermatology	NOUN
dpc-4871	2	77	and	and	CCONJ
dpc-4871	2	78	venereology	venereology	NOUN
dpc-4871	2	79	,	,	PUNCT
dpc-4871	2	80	department	department	NOUN
dpc-4871	2	81	of	of	ADP
dpc-4871	2	82	medicine	medicine	PROPN
dpc-4871	2	83	solna	solna	PROPN
dpc-4871	2	84	,	,	PUNCT
dpc-4871	2	85	and	and	CCONJ
dpc-4871	2	86	center	center	NOUN
dpc-4871	2	87	for	for	ADP
dpc-4871	2	88	molecular	molecular	ADJ
dpc-4871	2	89	medicine	medicine	NOUN
dpc-4871	2	90	,	,	PUNCT
dpc-4871	2	91	karolinska	karolinska	PROPN
dpc-4871	2	92	institutet	institutet	PROPN
dpc-4871	2	93	,	,	PUNCT
dpc-4871	2	94	stockholm	stockholm	PROPN
dpc-4871	2	95	,	,	PUNCT
dpc-4871	2	96	sweden	sweden	PROPN
dpc-4871	2	97	3	3	NUM
dpc-4871	2	98	department	department	NOUN
dpc-4871	2	99	of	of	ADP
dpc-4871	2	100	dermatology	dermatology	NOUN
dpc-4871	2	101	and	and	CCONJ
dpc-4871	2	102	venereology	venereology	NOUN
dpc-4871	2	103	,	,	PUNCT
dpc-4871	2	104	medical	medical	ADJ
dpc-4871	2	105	center	center	NOUN
dpc-4871	2	106	,	,	PUNCT
dpc-4871	2	107	university	university	NOUN
dpc-4871	2	108	of	of	ADP
dpc-4871	2	109	freiburg	freiburg	PROPN
dpc-4871	2	110	,	,	PUNCT
dpc-4871	2	111	faculty	faculty	NOUN
dpc-4871	2	112	of	of	ADP
dpc-4871	2	113	medicine	medicine	NOUN
dpc-4871	2	114	,	,	PUNCT
dpc-4871	2	115	university	university	NOUN
dpc-4871	2	116	of	of	ADP
dpc-4871	2	117	freiburg	freiburg	PROPN
dpc-4871	2	118	,	,	PUNCT
dpc-4871	2	119	freiburg	freiburg	PROPN
dpc-4871	2	120	,	,	PUNCT
dpc-4871	2	121	germany	germany	PROPN
dpc-4871	2	122	key	key	ADJ
dpc-4871	2	123	words	word	NOUN
dpc-4871	2	124	:	:	PUNCT
dpc-4871	2	125	generalized	generalize	VERB
dpc-4871	2	126	pustular	pustular	ADJ
dpc-4871	2	127	psoriasis	psoriasis	NOUN
dpc-4871	2	128	,	,	PUNCT
dpc-4871	2	129	palmoplantar	palmoplantar	NOUN
dpc-4871	2	130	pustular	pustular	ADJ
dpc-4871	2	131	pustulosis	pustulosis	NOUN
dpc-4871	2	132	,	,	PUNCT
dpc-4871	2	133	psoriasis	psoriasis	NOUN
dpc-4871	2	134	,	,	PUNCT
dpc-4871	2	135	biological	biological	ADJ
dpc-4871	2	136	therapy	therapy	NOUN
dpc-4871	2	137	,	,	PUNCT
dpc-4871	2	138	dlqi	dlqi	ADJ
dpc-4871	2	139	citation	citation	NOUN
dpc-4871	2	140	:	:	PUNCT
dpc-4871	2	141	buononato	buononato	NOUN
dpc-4871	2	142	d	d	PROPN
dpc-4871	2	143	,	,	PUNCT
dpc-4871	2	144	scala	scala	PROPN
dpc-4871	2	145	e	e	PROPN
dpc-4871	2	146	,	,	PUNCT
dpc-4871	2	147	benvenuto	benvenuto	PROPN
dpc-4871	2	148	p.	p.	NOUN
dpc-4871	2	149	real	real	ADJ
dpc-4871	2	150	-	-	PUNCT
dpc-4871	2	151	life	life	NOUN
dpc-4871	2	152	analysis	analysis	NOUN
dpc-4871	2	153	of	of	ADP
dpc-4871	2	154	therapeutic	therapeutic	ADJ
dpc-4871	2	155	management	management	NOUN
dpc-4871	2	156	and	and	CCONJ
dpc-4871	2	157	its	its	PRON
dpc-4871	2	158	correlation	correlation	NOUN
dpc-4871	2	159	with	with	ADP
dpc-4871	2	160	the	the	DET
dpc-4871	2	161	dermatology	dermatology	NOUN
dpc-4871	2	162	life	life	NOUN
dpc-4871	2	163	quality	quality	NOUN
dpc-4871	2	164	index	index	NOUN
dpc-4871	2	165	score	score	NOUN
dpc-4871	2	166	in	in	ADP
dpc-4871	2	167	108	108	NUM
dpc-4871	2	168	patients	patient	NOUN
dpc-4871	2	169	with	with	ADP
dpc-4871	2	170	pustular	pustular	ADJ
dpc-4871	2	171	psoriasis	psoriasis	NOUN
dpc-4871	2	172	:	:	PUNCT
dpc-4871	2	173	an	an	DET
dpc-4871	2	174	italian	italian	ADJ
dpc-4871	2	175	monocenter	monocenter	NOUN
dpc-4871	2	176	study	study	NOUN
dpc-4871	2	177	.	.	PUNCT
dpc-4871	3	1	dermatol	dermatol	NOUN
dpc-4871	3	2	pract	pract	PROPN
dpc-4871	3	3	concept	concept	NOUN
dpc-4871	3	4	.	.	PUNCT
dpc-4871	4	1	2025;15(1):4871	2025;15(1):4871	PROPN
dpc-4871	4	2	.	.	PUNCT
dpc-4871	5	1	doi	doi	PROPN
dpc-4871	5	2	:	:	PUNCT
dpc-4871	5	3	https://doi.org/10.5826/dpc.1501a4871	https://doi.org/10.5826/dpc.1501a4871	PROPN
dpc-4871	5	4	accepted	accept	VERB
dpc-4871	5	5	:	:	PUNCT
dpc-4871	5	6	october	october	PROPN
dpc-4871	5	7	10	10	NUM
dpc-4871	5	8	,	,	PUNCT
dpc-4871	5	9	2024	2024	NUM
dpc-4871	5	10	;	;	PUNCT
dpc-4871	5	11	published	publish	VERB
dpc-4871	5	12	:	:	PUNCT
dpc-4871	6	1	january	january	PROPN
dpc-4871	6	2	2025	2025	NUM
dpc-4871	6	3	copyright	copyright	NOUN
dpc-4871	6	4	:	:	PUNCT
dpc-4871	6	5	©	©	PROPN
dpc-4871	6	6	2024	2024	NUM
dpc-4871	6	7	buononato	buononato	NOUN
dpc-4871	6	8	et	et	NOUN
dpc-4871	6	9	al	al	PROPN
dpc-4871	6	10	.	.	PUNCT
dpc-4871	7	1	this	this	PRON
dpc-4871	7	2	is	be	AUX
dpc-4871	7	3	an	an	DET
dpc-4871	7	4	open	open	ADJ
dpc-4871	7	5	-	-	PUNCT
dpc-4871	7	6	access	access	NOUN
dpc-4871	7	7	article	article	NOUN
dpc-4871	7	8	distributed	distribute	VERB
dpc-4871	7	9	under	under	ADP
dpc-4871	7	10	the	the	DET
dpc-4871	7	11	terms	term	NOUN
dpc-4871	7	12	of	of	ADP
dpc-4871	7	13	the	the	DET
dpc-4871	7	14	creative	creative	ADJ
dpc-4871	7	15	commons	common	NOUN
dpc-4871	7	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-4871	7	17	license	license	NOUN
dpc-4871	7	18	(	(	PUNCT
dpc-4871	7	19	by	by	ADP
dpc-4871	7	20	-	-	PUNCT
dpc-4871	7	21	nc-4.0	nc-4.0	NOUN
dpc-4871	7	22	)	)	PUNCT
dpc-4871	7	23	,	,	PUNCT
dpc-4871	7	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-4871	7	25	,	,	PUNCT
dpc-4871	7	26	which	which	PRON
dpc-4871	7	27	permits	permit	VERB
dpc-4871	7	28	unrestricted	unrestricted	ADJ
dpc-4871	7	29	noncommercial	noncommercial	ADJ
dpc-4871	7	30	use	use	NOUN
dpc-4871	7	31	,	,	PUNCT
dpc-4871	7	32	distribution	distribution	NOUN
dpc-4871	7	33	,	,	PUNCT
dpc-4871	7	34	and	and	CCONJ
dpc-4871	7	35	reproduction	reproduction	NOUN
dpc-4871	7	36	in	in	ADP
dpc-4871	7	37	any	any	DET
dpc-4871	7	38	medium	medium	NOUN
dpc-4871	7	39	,	,	PUNCT
dpc-4871	7	40	provided	provide	VERB
dpc-4871	7	41	the	the	DET
dpc-4871	7	42	original	original	ADJ
dpc-4871	7	43	authors	author	NOUN
dpc-4871	7	44	and	and	CCONJ
dpc-4871	7	45	source	source	NOUN
dpc-4871	7	46	are	be	AUX
dpc-4871	7	47	credited	credit	VERB
dpc-4871	7	48	.	.	PUNCT
dpc-4871	8	1	funding	funding	NOUN
dpc-4871	8	2	:	:	PUNCT
dpc-4871	8	3	none	none	NOUN
dpc-4871	8	4	.	.	PUNCT
dpc-4871	9	1	competing	compete	VERB
dpc-4871	9	2	interests	interest	NOUN
dpc-4871	9	3	:	:	PUNCT
dpc-4871	9	4	none	none	NOUN
dpc-4871	9	5	.	.	PUNCT
dpc-4871	10	1	authorship	authorship	NOUN
dpc-4871	10	2	:	:	PUNCT
dpc-4871	10	3	all	all	DET
dpc-4871	10	4	authors	author	NOUN
dpc-4871	10	5	have	have	AUX
dpc-4871	10	6	contributed	contribute	VERB
dpc-4871	10	7	significantly	significantly	ADV
dpc-4871	10	8	to	to	ADP
dpc-4871	10	9	this	this	DET
dpc-4871	10	10	publication	publication	NOUN
dpc-4871	10	11	.	.	PUNCT
dpc-4871	11	1	corresponding	correspond	VERB
dpc-4871	11	2	author	author	NOUN
dpc-4871	11	3	:	:	PUNCT
dpc-4871	11	4	prof	prof	PROPN
dpc-4871	11	5	.	.	PROPN
dpc-4871	11	6	anna	anna	PROPN
dpc-4871	11	7	balato	balato	PROPN
dpc-4871	11	8	,	,	PUNCT
dpc-4871	11	9	md	md	PROPN
dpc-4871	11	10	,	,	PUNCT
dpc-4871	11	11	phd	phd	NOUN
dpc-4871	11	12	,	,	PUNCT
dpc-4871	11	13	unit	unit	NOUN
dpc-4871	11	14	of	of	ADP
dpc-4871	11	15	dermatology	dermatology	NOUN
dpc-4871	11	16	,	,	PUNCT
dpc-4871	11	17	university	university	PROPN
dpc-4871	11	18	of	of	ADP
dpc-4871	11	19	campania	campania	PROPN
dpc-4871	11	20	“	"	PUNCT
dpc-4871	11	21	luigi	luigi	PROPN
dpc-4871	11	22	vanvitelli	vanvitelli	PROPN
dpc-4871	11	23	”	"	PUNCT
dpc-4871	11	24	,	,	PUNCT
dpc-4871	11	25	via	via	ADP
dpc-4871	11	26	s.	s.	PROPN
dpc-4871	11	27	pansini	pansini	PROPN
dpc-4871	11	28	,	,	PUNCT
dpc-4871	11	29	5	5	NUM
dpc-4871	11	30	,	,	PUNCT
dpc-4871	11	31	80131	80131	NUM
dpc-4871	11	32	,	,	PUNCT
dpc-4871	11	33	naples	naples	PROPN
dpc-4871	11	34	,	,	PUNCT
dpc-4871	11	35	italy	italy	PROPN
dpc-4871	11	36	.	.	PUNCT
dpc-4871	12	1	e	e	X
dpc-4871	12	2	-	-	NOUN
dpc-4871	12	3	mail	mail	NOUN
dpc-4871	12	4	:	:	PUNCT
dpc-4871	12	5	annabalato@yahoo.it	annabalato@yahoo.it	PROPN
dpc-4871	12	6	introduction	introduction	NOUN
dpc-4871	12	7	:	:	PUNCT
dpc-4871	12	8	pustular	pustular	ADJ
dpc-4871	12	9	psoriasis	psoriasis	NOUN
dpc-4871	12	10	(	(	PUNCT
dpc-4871	12	11	pp	pp	ADJ
dpc-4871	12	12	)	)	PUNCT
dpc-4871	12	13	is	be	AUX
dpc-4871	12	14	a	a	DET
dpc-4871	12	15	rare	rare	ADJ
dpc-4871	12	16	life	life	NOUN
dpc-4871	12	17	-	-	PUNCT
dpc-4871	12	18	threatening	threaten	VERB
dpc-4871	12	19	skin	skin	NOUN
dpc-4871	12	20	disease	disease	NOUN
dpc-4871	12	21	with	with	ADP
dpc-4871	12	22	negatively	negatively	ADV
dpc-4871	12	23	impact	impact	NOUN
dpc-4871	12	24	on	on	ADP
dpc-4871	12	25	quality	quality	NOUN
dpc-4871	12	26	of	of	ADP
dpc-4871	12	27	life	life	NOUN
dpc-4871	12	28	(	(	PUNCT
dpc-4871	12	29	qol	qol	NOUN
dpc-4871	12	30	)	)	PUNCT
dpc-4871	12	31	.	.	PUNCT
dpc-4871	13	1	clinically	clinically	ADV
dpc-4871	13	2	,	,	PUNCT
dpc-4871	13	3	it	it	PRON
dpc-4871	13	4	may	may	AUX
dpc-4871	13	5	be	be	AUX
dpc-4871	13	6	systemic	systemic	ADJ
dpc-4871	13	7	(	(	PUNCT
dpc-4871	13	8	generalized	generalize	VERB
dpc-4871	13	9	pustular	pustular	ADJ
dpc-4871	13	10	psoriasis	psoriasis	NOUN
dpc-4871	13	11	[	[	X
dpc-4871	13	12	gpp	gpp	NOUN
dpc-4871	13	13	]	]	X
dpc-4871	13	14	)	)	PUNCT
dpc-4871	13	15	or	or	CCONJ
dpc-4871	13	16	localized	localize	VERB
dpc-4871	13	17	on	on	ADP
dpc-4871	13	18	palms	palm	NOUN
dpc-4871	13	19	and	and	CCONJ
dpc-4871	13	20	soles	sol	NOUN
dpc-4871	13	21	(	(	PUNCT
dpc-4871	13	22	palmoplantar	palmoplantar	NOUN
dpc-4871	13	23	pustulosis	pustulosis	NOUN
dpc-4871	14	1	[	[	X
dpc-4871	14	2	ppp	ppp	NOUN
dpc-4871	14	3	]	]	PUNCT
dpc-4871	14	4	)	)	PUNCT
dpc-4871	14	5	.	.	PUNCT
dpc-4871	15	1	it	it	PRON
dpc-4871	15	2	is	be	AUX
dpc-4871	15	3	not	not	PART
dpc-4871	15	4	rare	rare	ADJ
dpc-4871	15	5	to	to	PART
dpc-4871	15	6	observe	observe	VERB
dpc-4871	15	7	plaque	plaque	NOUN
dpc-4871	15	8	psoriasis	psoriasis	NOUN
dpc-4871	15	9	associated	associate	VERB
dpc-4871	15	10	with	with	ADP
dpc-4871	15	11	gpp	gpp	NOUN
dpc-4871	15	12	.	.	PUNCT
dpc-4871	16	1	objectives	objective	NOUN
dpc-4871	16	2	:	:	PUNCT
dpc-4871	16	3	we	we	PRON
dpc-4871	16	4	explored	explore	VERB
dpc-4871	16	5	the	the	DET
dpc-4871	16	6	therapies	therapy	NOUN
dpc-4871	16	7	used	use	VERB
dpc-4871	16	8	for	for	ADP
dpc-4871	16	9	pp	pp	ADV
dpc-4871	16	10	and	and	CCONJ
dpc-4871	16	11	their	their	PRON
dpc-4871	16	12	correlation	correlation	NOUN
dpc-4871	16	13	with	with	ADP
dpc-4871	16	14	patient	patient	ADJ
dpc-4871	16	15	qol	qol	PROPN
dpc-4871	16	16	scores	score	NOUN
dpc-4871	16	17	,	,	PUNCT
dpc-4871	16	18	through	through	ADP
dpc-4871	16	19	a	a	DET
dpc-4871	16	20	cross	cross	ADJ
dpc-4871	16	21	-	-	ADJ
dpc-4871	16	22	sectional	sectional	ADJ
dpc-4871	16	23	study	study	NOUN
dpc-4871	16	24	using	use	VERB
dpc-4871	16	25	retrospective	retrospective	ADJ
dpc-4871	16	26	data	datum	NOUN
dpc-4871	16	27	from	from	ADP
dpc-4871	16	28	a	a	DET
dpc-4871	16	29	monocentric	monocentric	ADJ
dpc-4871	16	30	database	database	NOUN
dpc-4871	16	31	in	in	ADP
dpc-4871	16	32	the	the	DET
dpc-4871	16	33	period	period	NOUN
dpc-4871	16	34	2017	2017	NUM
dpc-4871	16	35	-	-	SYM
dpc-4871	16	36	2021	2021	NUM
dpc-4871	16	37	.	.	PUNCT
dpc-4871	17	1	methods	method	NOUN
dpc-4871	17	2	:	:	PUNCT
dpc-4871	17	3	patient	patient	ADJ
dpc-4871	17	4	characteristics	characteristic	NOUN
dpc-4871	17	5	were	be	AUX
dpc-4871	17	6	summarized	summarize	VERB
dpc-4871	17	7	using	use	VERB
dpc-4871	17	8	descriptive	descriptive	ADJ
dpc-4871	17	9	statistics	statistic	NOUN
dpc-4871	17	10	and	and	CCONJ
dpc-4871	17	11	treatment	treatment	NOUN
dpc-4871	17	12	predictors	predictor	NOUN
dpc-4871	17	13	of	of	ADP
dpc-4871	17	14	qol	qol	PROPN
dpc-4871	17	15	were	be	AUX
dpc-4871	17	16	identified	identify	VERB
dpc-4871	17	17	by	by	ADP
dpc-4871	17	18	multiple	multiple	ADJ
dpc-4871	17	19	regression	regression	NOUN
dpc-4871	17	20	analysis	analysis	NOUN
dpc-4871	17	21	.	.	PUNCT
dpc-4871	18	1	among	among	ADP
dpc-4871	18	2	108	108	NUM
dpc-4871	18	3	patients	patient	NOUN
dpc-4871	18	4	with	with	ADP
dpc-4871	18	5	pp	pp	PROPN
dpc-4871	18	6	,	,	PUNCT
dpc-4871	18	7	57.4	57.4	NUM
dpc-4871	18	8	%	%	NOUN
dpc-4871	18	9	had	have	AUX
dpc-4871	18	10	gpp	gpp	NOUN
dpc-4871	18	11	+	+	X
dpc-4871	18	12	pso	pso	NOUN
dpc-4871	18	13	whereas	whereas	SCONJ
dpc-4871	18	14	42.6	42.6	NUM
dpc-4871	18	15	%	%	NOUN
dpc-4871	18	16	had	have	VERB
dpc-4871	18	17	ppp	ppp	NOUN
dpc-4871	18	18	.	.	PUNCT
dpc-4871	19	1	the	the	DET
dpc-4871	19	2	therapeutic	therapeutic	ADJ
dpc-4871	19	3	management	management	NOUN
dpc-4871	19	4	is	be	AUX
dpc-4871	19	5	based	base	VERB
dpc-4871	19	6	on	on	ADP
dpc-4871	19	7	systemic	systemic	ADJ
dpc-4871	19	8	conventional	conventional	ADJ
dpc-4871	19	9	treatments	treatment	NOUN
dpc-4871	19	10	and	and	CCONJ
dpc-4871	19	11	biological	biological	ADJ
dpc-4871	19	12	therapies	therapy	NOUN
dpc-4871	19	13	in	in	ADP
dpc-4871	19	14	both	both	DET
dpc-4871	19	15	gpp	gpp	NOUN
dpc-4871	19	16	and	and	CCONJ
dpc-4871	19	17	ppp	ppp	NOUN
dpc-4871	19	18	.	.	PUNCT
dpc-4871	20	1	abstract	abstract	ADJ
dpc-4871	20	2	2	2	NUM
dpc-4871	20	3	original	original	ADJ
dpc-4871	20	4	article	article	NOUN
dpc-4871	20	5	|	|	ADV
dpc-4871	20	6	dermatol	dermatol	ADJ
dpc-4871	20	7	pract	pract	NOUN
dpc-4871	20	8	concept	concept	NOUN
dpc-4871	20	9	.	.	PUNCT
dpc-4871	21	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	21	2	introduction	introduction	NOUN
dpc-4871	21	3	pustular	pustular	ADJ
dpc-4871	21	4	psoriasis	psoriasis	NOUN
dpc-4871	21	5	(	(	PUNCT
dpc-4871	21	6	pp	pp	ADJ
dpc-4871	21	7	)	)	PUNCT
dpc-4871	21	8	is	be	AUX
dpc-4871	21	9	a	a	DET
dpc-4871	21	10	rare	rare	ADJ
dpc-4871	21	11	,	,	PUNCT
dpc-4871	21	12	life	life	NOUN
dpc-4871	21	13	-	-	PUNCT
dpc-4871	21	14	threatening	threaten	VERB
dpc-4871	21	15	skin	skin	NOUN
dpc-4871	21	16	disease	disease	NOUN
dpc-4871	21	17	characterized	characterize	VERB
dpc-4871	21	18	by	by	ADP
dpc-4871	21	19	eruptions	eruption	NOUN
dpc-4871	21	20	of	of	ADP
dpc-4871	21	21	neutrophil	neutrophil	ADJ
dpc-4871	21	22	-	-	PUNCT
dpc-4871	21	23	filled	fill	VERB
dpc-4871	21	24	pustules	pustule	NOUN
dpc-4871	21	25	[	[	X
dpc-4871	21	26	1	1	NUM
dpc-4871	21	27	]	]	PUNCT
dpc-4871	21	28	.	.	PUNCT
dpc-4871	22	1	the	the	DET
dpc-4871	22	2	condition	condition	NOUN
dpc-4871	22	3	imposes	impose	VERB
dpc-4871	22	4	a	a	DET
dpc-4871	22	5	substantial	substantial	ADJ
dpc-4871	22	6	emotional	emotional	ADJ
dpc-4871	22	7	burden	burden	NOUN
dpc-4871	22	8	on	on	ADP
dpc-4871	22	9	patients	patient	NOUN
dpc-4871	22	10	impacting	impact	VERB
dpc-4871	22	11	on	on	ADP
dpc-4871	22	12	quality	quality	NOUN
dpc-4871	22	13	of	of	ADP
dpc-4871	22	14	life	life	NOUN
dpc-4871	22	15	(	(	PUNCT
dpc-4871	22	16	qol	qol	NOUN
dpc-4871	22	17	)	)	PUNCT
dpc-4871	22	18	and	and	CCONJ
dpc-4871	22	19	their	their	PRON
dpc-4871	22	20	daily	daily	ADJ
dpc-4871	22	21	activities	activity	NOUN
dpc-4871	22	22	[	[	X
dpc-4871	22	23	2	2	NUM
dpc-4871	22	24	]	]	PUNCT
dpc-4871	22	25	.	.	PUNCT
dpc-4871	23	1	pp	pp	PROPN
dpc-4871	23	2	has	have	VERB
dpc-4871	23	3	2	2	NUM
dpc-4871	23	4	subtypes	subtype	NOUN
dpc-4871	23	5	:	:	PUNCT
dpc-4871	23	6	generalized	generalize	VERB
dpc-4871	23	7	pustular	pustular	ADJ
dpc-4871	23	8	psoriasis	psoriasis	NOUN
dpc-4871	23	9	(	(	PUNCT
dpc-4871	23	10	gpp	gpp	NOUN
dpc-4871	23	11	)	)	PUNCT
dpc-4871	23	12	and	and	CCONJ
dpc-4871	23	13	localized	localize	VERB
dpc-4871	23	14	on	on	ADP
dpc-4871	23	15	palms	palm	NOUN
dpc-4871	23	16	and	and	CCONJ
dpc-4871	23	17	soles	sol	NOUN
dpc-4871	23	18	,	,	PUNCT
dpc-4871	23	19	called	call	VERB
dpc-4871	23	20	palmoplantar	palmoplantar	NOUN
dpc-4871	23	21	pustulosis	pustulosis	NOUN
dpc-4871	23	22	(	(	PUNCT
dpc-4871	23	23	ppp	ppp	NOUN
dpc-4871	23	24	)	)	PUNCT
dpc-4871	23	25	.	.	PUNCT
dpc-4871	24	1	it	it	PRON
dpc-4871	24	2	is	be	AUX
dpc-4871	24	3	not	not	PART
dpc-4871	24	4	rare	rare	ADJ
dpc-4871	24	5	to	to	PART
dpc-4871	24	6	observe	observe	VERB
dpc-4871	24	7	plaque	plaque	NOUN
dpc-4871	24	8	psoriasis	psoriasis	NOUN
dpc-4871	24	9	associated	associate	VERB
dpc-4871	24	10	with	with	ADP
dpc-4871	24	11	generalized	generalized	ADJ
dpc-4871	24	12	pustular	pustular	ADJ
dpc-4871	24	13	forms	form	NOUN
dpc-4871	24	14	of	of	ADP
dpc-4871	24	15	psoriasis	psoriasis	NOUN
dpc-4871	24	16	(	(	PUNCT
dpc-4871	24	17	gpp	gpp	NOUN
dpc-4871	24	18	+	+	CCONJ
dpc-4871	24	19	pso	pso	NOUN
dpc-4871	24	20	)	)	PUNCT
dpc-4871	24	21	.	.	PUNCT
dpc-4871	25	1	the	the	DET
dpc-4871	25	2	involvement	involvement	NOUN
dpc-4871	25	3	of	of	ADP
dpc-4871	25	4	the	the	DET
dpc-4871	25	5	fingers	finger	NOUN
dpc-4871	25	6	,	,	PUNCT
dpc-4871	25	7	toes	toe	NOUN
dpc-4871	25	8	,	,	PUNCT
dpc-4871	25	9	and	and	CCONJ
dpc-4871	25	10	nails	nail	NOUN
dpc-4871	25	11	is	be	AUX
dpc-4871	25	12	defined	define	VERB
dpc-4871	25	13	as	as	ADP
dpc-4871	25	14	a	a	DET
dpc-4871	25	15	separate	separate	ADJ
dpc-4871	25	16	localized	localized	ADJ
dpc-4871	25	17	variant	variant	NOUN
dpc-4871	25	18	,	,	PUNCT
dpc-4871	25	19	acrodermatitis	acrodermatitis	NOUN
dpc-4871	25	20	continua	continua	NOUN
dpc-4871	25	21	of	of	ADP
dpc-4871	25	22	hallopeau	hallopeau	PROPN
dpc-4871	25	23	,	,	PUNCT
dpc-4871	25	24	and	and	CCONJ
dpc-4871	25	25	is	be	AUX
dpc-4871	25	26	now	now	ADV
dpc-4871	25	27	thought	think	VERB
dpc-4871	25	28	to	to	PART
dpc-4871	25	29	be	be	AUX
dpc-4871	25	30	a	a	DET
dpc-4871	25	31	subset	subset	NOUN
dpc-4871	25	32	of	of	ADP
dpc-4871	25	33	ppp	ppp	NOUN
dpc-4871	25	34	 	 	SPACE
dpc-4871	26	1	[	[	X
dpc-4871	26	2	3	3	NUM
dpc-4871	26	3	]	]	PUNCT
dpc-4871	26	4	.	.	PUNCT
dpc-4871	27	1	immunologically	immunologically	ADV
dpc-4871	27	2	,	,	PUNCT
dpc-4871	27	3	pp	pp	ADV
dpc-4871	27	4	seems	seem	VERB
dpc-4871	27	5	to	to	PART
dpc-4871	27	6	be	be	AUX
dpc-4871	27	7	characterized	characterize	VERB
dpc-4871	27	8	by	by	ADP
dpc-4871	27	9	an	an	DET
dpc-4871	27	10	intense	intense	ADJ
dpc-4871	27	11	inflammatory	inflammatory	ADJ
dpc-4871	27	12	response	response	NOUN
dpc-4871	27	13	resulting	result	VERB
dpc-4871	27	14	from	from	ADP
dpc-4871	27	15	innate	innate	ADJ
dpc-4871	27	16	immunity	immunity	NOUN
dpc-4871	27	17	hyperactivation	hyperactivation	NOUN
dpc-4871	27	18	,	,	PUNCT
dpc-4871	27	19	with	with	ADP
dpc-4871	27	20	prominent	prominent	ADJ
dpc-4871	27	21	involvement	involvement	NOUN
dpc-4871	27	22	of	of	ADP
dpc-4871	27	23	the	the	DET
dpc-4871	27	24	il-36	il-36	NOUN
dpc-4871	27	25	axis	axis	NOUN
dpc-4871	28	1	[	[	X
dpc-4871	28	2	4	4	NUM
dpc-4871	28	3	]	]	PUNCT
dpc-4871	28	4	.	.	PUNCT
dpc-4871	29	1	however	however	ADV
dpc-4871	29	2	,	,	PUNCT
dpc-4871	29	3	recent	recent	ADJ
dpc-4871	29	4	progresses	progress	NOUN
dpc-4871	29	5	in	in	ADP
dpc-4871	29	6	the	the	DET
dpc-4871	29	7	identification	identification	NOUN
dpc-4871	29	8	of	of	ADP
dpc-4871	29	9	genetic	genetic	ADJ
dpc-4871	29	10	mutations	mutation	NOUN
dpc-4871	29	11	have	have	AUX
dpc-4871	29	12	promoted	promote	VERB
dpc-4871	29	13	a	a	DET
dpc-4871	29	14	better	well	ADJ
dpc-4871	29	15	understanding	understanding	NOUN
dpc-4871	29	16	of	of	ADP
dpc-4871	29	17	pp	pp	ADP
dpc-4871	29	18	pathogenesis	pathogenesis	NOUN
dpc-4871	29	19	highlighting	highlight	VERB
dpc-4871	29	20	that	that	SCONJ
dpc-4871	29	21	gpp	gpp	NOUN
dpc-4871	29	22	and	and	CCONJ
dpc-4871	29	23	ppp	ppp	NOUN
dpc-4871	29	24	are	be	AUX
dpc-4871	29	25	genetically	genetically	ADV
dpc-4871	29	26	and	and	CCONJ
dpc-4871	29	27	pathologically	pathologically	ADV
dpc-4871	29	28	distinct	distinct	ADJ
dpc-4871	29	29	conditions	condition	NOUN
dpc-4871	29	30	[	[	X
dpc-4871	29	31	5	5	NUM
dpc-4871	29	32	]	]	PUNCT
dpc-4871	29	33	.	.	PUNCT
dpc-4871	30	1	briefly	briefly	NOUN
dpc-4871	30	2	,	,	PUNCT
dpc-4871	30	3	il36rn	il36rn	PROPN
dpc-4871	30	4	mutations	mutation	NOUN
dpc-4871	30	5	are	be	AUX
dpc-4871	30	6	the	the	DET
dpc-4871	30	7	most	most	ADV
dpc-4871	30	8	frequent	frequent	ADJ
dpc-4871	30	9	genetic	genetic	ADJ
dpc-4871	30	10	abnormality	abnormality	NOUN
dpc-4871	30	11	in	in	ADP
dpc-4871	30	12	gpp	gpp	NOUN
dpc-4871	30	13	[	[	X
dpc-4871	30	14	3,6	3,6	NUM
dpc-4871	30	15	]	]	PUNCT
dpc-4871	30	16	,	,	PUNCT
dpc-4871	30	17	card14	card14	NOUN
dpc-4871	30	18	mutations	mutation	NOUN
dpc-4871	30	19	are	be	AUX
dpc-4871	30	20	primarily	primarily	ADV
dpc-4871	30	21	present	present	ADJ
dpc-4871	30	22	in	in	ADP
dpc-4871	30	23	gpp	gpp	NOUN
dpc-4871	30	24	+	+	CCONJ
dpc-4871	30	25	pso	pso	NOUN
dpc-4871	30	26	and	and	CCONJ
dpc-4871	30	27	rarely	rarely	ADV
dpc-4871	30	28	in	in	ADP
dpc-4871	30	29	gpp	gpp	NOUN
dpc-4871	30	30	alone	alone	ADV
dpc-4871	30	31	[	[	X
dpc-4871	30	32	7,8	7,8	NUM
dpc-4871	30	33	]	]	PUNCT
dpc-4871	30	34	and	and	CCONJ
dpc-4871	30	35	these	these	DET
dpc-4871	30	36	genetic	genetic	ADJ
dpc-4871	30	37	abnormalities	abnormality	NOUN
dpc-4871	30	38	account	account	VERB
dpc-4871	30	39	for	for	ADP
dpc-4871	30	40	only	only	ADV
dpc-4871	30	41	a	a	DET
dpc-4871	30	42	minority	minority	NOUN
dpc-4871	30	43	of	of	ADP
dpc-4871	30	44	ppp	ppp	NOUN
dpc-4871	30	45	cases	case	NOUN
dpc-4871	30	46	.	.	PUNCT
dpc-4871	31	1	nevertheless	nevertheless	ADV
dpc-4871	31	2	,	,	PUNCT
dpc-4871	31	3	il36γ	il36γ	NOUN
dpc-4871	31	4	gene	gene	NOUN
dpc-4871	31	5	,	,	PUNCT
dpc-4871	31	6	which	which	PRON
dpc-4871	31	7	encodes	encode	VERB
dpc-4871	31	8	the	the	DET
dpc-4871	31	9	inflammatory	inflammatory	ADJ
dpc-4871	31	10	cytokine	cytokine	NOUN
dpc-4871	31	11	il-36γ	il-36γ	NOUN
dpc-4871	31	12	,	,	PUNCT
dpc-4871	31	13	is	be	AUX
dpc-4871	31	14	upregulated	upregulate	VERB
dpc-4871	31	15	in	in	ADP
dpc-4871	31	16	patients	patient	NOUN
dpc-4871	31	17	with	with	ADP
dpc-4871	31	18	ppp	ppp	NOUN
dpc-4871	31	19	,	,	PUNCT
dpc-4871	31	20	indicating	indicate	VERB
dpc-4871	31	21	that	that	SCONJ
dpc-4871	31	22	a	a	DET
dpc-4871	31	23	dysregulation	dysregulation	NOUN
dpc-4871	31	24	of	of	ADP
dpc-4871	31	25	the	the	DET
dpc-4871	31	26	il-36	il-36	NOUN
dpc-4871	31	27	pathway	pathway	NOUN
dpc-4871	31	28	exists	exist	VERB
dpc-4871	31	29	in	in	ADP
dpc-4871	31	30	the	the	DET
dpc-4871	31	31	development	development	NOUN
dpc-4871	31	32	of	of	ADP
dpc-4871	31	33	these	these	DET
dpc-4871	31	34	skin	skin	NOUN
dpc-4871	31	35	conditions	condition	NOUN
dpc-4871	31	36	[	[	X
dpc-4871	31	37	9	9	NUM
dpc-4871	31	38	]	]	PUNCT
dpc-4871	31	39	.	.	PUNCT
dpc-4871	32	1	however	however	ADV
dpc-4871	32	2	,	,	PUNCT
dpc-4871	32	3	because	because	SCONJ
dpc-4871	32	4	of	of	ADP
dpc-4871	32	5	the	the	DET
dpc-4871	32	6	rarity	rarity	NOUN
dpc-4871	32	7	and	and	CCONJ
dpc-4871	32	8	heterogeneity	heterogeneity	NOUN
dpc-4871	32	9	of	of	ADP
dpc-4871	32	10	pp	pp	ADP
dpc-4871	32	11	forms	form	NOUN
dpc-4871	32	12	,	,	PUNCT
dpc-4871	32	13	data	datum	NOUN
dpc-4871	32	14	on	on	ADP
dpc-4871	32	15	prognosis	prognosis	NOUN
dpc-4871	32	16	and	and	CCONJ
dpc-4871	32	17	therapeutic	therapeutic	ADJ
dpc-4871	32	18	management	management	NOUN
dpc-4871	32	19	are	be	AUX
dpc-4871	32	20	limited	limited	ADJ
dpc-4871	32	21	.	.	PUNCT
dpc-4871	33	1	to	to	ADP
dpc-4871	33	2	date	date	NOUN
dpc-4871	33	3	,	,	PUNCT
dpc-4871	33	4	the	the	DET
dpc-4871	33	5	management	management	NOUN
dpc-4871	33	6	is	be	AUX
dpc-4871	33	7	based	base	VERB
dpc-4871	33	8	on	on	ADP
dpc-4871	33	9	existing	exist	VERB
dpc-4871	33	10	anti	anti	ADJ
dpc-4871	33	11	-	-	ADJ
dpc-4871	33	12	psoriatic	psoriatic	ADJ
dpc-4871	33	13	therapies	therapy	NOUN
dpc-4871	33	14	including	include	VERB
dpc-4871	33	15	systemic	systemic	ADJ
dpc-4871	33	16	conventional	conventional	ADJ
dpc-4871	33	17	treatments	treatment	NOUN
dpc-4871	33	18	(	(	PUNCT
dpc-4871	33	19	eg	eg	NOUN
dpc-4871	33	20	acitretin	acitretin	PROPN
dpc-4871	33	21	,	,	PUNCT
dpc-4871	33	22	cyclosporine	cyclosporine	NOUN
dpc-4871	33	23	and	and	CCONJ
dpc-4871	33	24	methotrexate	methotrexate	VERB
dpc-4871	33	25	)	)	PUNCT
dpc-4871	33	26	and	and	CCONJ
dpc-4871	33	27	biological	biological	ADJ
dpc-4871	33	28	therapies	therapy	NOUN
dpc-4871	33	29	(	(	PUNCT
dpc-4871	33	30	eg	eg	NOUN
dpc-4871	33	31	anti	anti	NOUN
dpc-4871	33	32	-	-	NOUN
dpc-4871	33	33	tnfα	tnfα	ADJ
dpc-4871	33	34	,	,	PUNCT
dpc-4871	33	35	anti	anti	ADJ
dpc-4871	33	36	-	-	ADJ
dpc-4871	33	37	il12/23	il12/23	ADJ
dpc-4871	33	38	,	,	PUNCT
dpc-4871	33	39	anti	anti	ADJ
dpc-4871	33	40	-	-	ADJ
dpc-4871	33	41	il23	il23	ADJ
dpc-4871	33	42	,	,	PUNCT
dpc-4871	33	43	and	and	CCONJ
dpc-4871	33	44	anti	anti	ADJ
dpc-4871	33	45	-	-	ADJ
dpc-4871	33	46	il17	il17	PROPN
dpc-4871	33	47	)	)	PUNCT
dpc-4871	33	48	which	which	PRON
dpc-4871	33	49	often	often	ADV
dpc-4871	33	50	show	show	VERB
dpc-4871	33	51	weak	weak	ADJ
dpc-4871	33	52	evidence	evidence	NOUN
dpc-4871	33	53	of	of	ADP
dpc-4871	33	54	efficacy	efficacy	NOUN
dpc-4871	33	55	in	in	ADP
dpc-4871	33	56	both	both	DET
dpc-4871	33	57	gpp	gpp	NOUN
dpc-4871	33	58	and	and	CCONJ
dpc-4871	33	59	ppp	ppp	NOUN
dpc-4871	34	1	[	[	X
dpc-4871	34	2	9	9	NUM
dpc-4871	34	3	]	]	PUNCT
dpc-4871	34	4	.	.	PUNCT
dpc-4871	35	1	recently	recently	ADV
dpc-4871	35	2	,	,	PUNCT
dpc-4871	35	3	an	an	DET
dpc-4871	35	4	il-36	il-36	NOUN
dpc-4871	35	5	receptor	receptor	NOUN
dpc-4871	35	6	inhibitor	inhibitor	NOUN
dpc-4871	35	7	,	,	PUNCT
dpc-4871	35	8	called	call	VERB
dpc-4871	35	9	spesolimab	spesolimab	NOUN
dpc-4871	35	10	,	,	PUNCT
dpc-4871	35	11	has	have	AUX
dpc-4871	35	12	been	be	AUX
dpc-4871	35	13	approved	approve	VERB
dpc-4871	35	14	in	in	ADP
dpc-4871	35	15	usa	usa	PROPN
dpc-4871	35	16	and	and	CCONJ
dpc-4871	35	17	japan	japan	PROPN
dpc-4871	35	18	for	for	ADP
dpc-4871	35	19	the	the	DET
dpc-4871	35	20	treatment	treatment	NOUN
dpc-4871	35	21	of	of	ADP
dpc-4871	35	22	gpp	gpp	NOUN
dpc-4871	35	23	in	in	ADP
dpc-4871	35	24	adults	adult	NOUN
dpc-4871	35	25	[	[	X
dpc-4871	35	26	10	10	NUM
dpc-4871	35	27	]	]	PUNCT
dpc-4871	35	28	.	.	PUNCT
dpc-4871	36	1	clinical	clinical	ADJ
dpc-4871	36	2	trials	trial	NOUN
dpc-4871	36	3	have	have	AUX
dpc-4871	36	4	shown	show	VERB
dpc-4871	36	5	that	that	SCONJ
dpc-4871	36	6	this	this	PRON
dpc-4871	36	7	humanized	humanize	VERB
dpc-4871	36	8	,	,	PUNCT
dpc-4871	36	9	selective	selective	ADJ
dpc-4871	36	10	antibody	antibody	NOUN
dpc-4871	36	11	can	can	AUX
dpc-4871	36	12	be	be	AUX
dpc-4871	36	13	a	a	DET
dpc-4871	36	14	safe	safe	ADJ
dpc-4871	36	15	and	and	CCONJ
dpc-4871	36	16	effective	effective	ADJ
dpc-4871	36	17	maintenance	maintenance	NOUN
dpc-4871	36	18	treatment	treatment	NOUN
dpc-4871	36	19	that	that	PRON
dpc-4871	36	20	prevents	prevent	VERB
dpc-4871	36	21	gpp	gpp	NOUN
dpc-4871	36	22	flareups	flareup	NOUN
dpc-4871	36	23	and	and	CCONJ
dpc-4871	36	24	controls	control	VERB
dpc-4871	36	25	its	its	PRON
dpc-4871	36	26	associated	associated	ADJ
dpc-4871	36	27	symptoms	symptom	NOUN
dpc-4871	36	28	[	[	X
dpc-4871	36	29	11	11	NUM
dpc-4871	36	30	]	]	PUNCT
dpc-4871	36	31	.	.	PUNCT
dpc-4871	37	1	currently	currently	ADV
dpc-4871	37	2	,	,	PUNCT
dpc-4871	37	3	a	a	DET
dpc-4871	37	4	phase	phase	NOUN
dpc-4871	37	5	2	2	NUM
dpc-4871	37	6	clinical	clinical	ADJ
dpc-4871	37	7	study	study	NOUN
dpc-4871	37	8	is	be	AUX
dpc-4871	37	9	evaluating	evaluate	VERB
dpc-4871	37	10	the	the	DET
dpc-4871	37	11	effectiveness	effectiveness	NOUN
dpc-4871	37	12	and	and	CCONJ
dpc-4871	37	13	safety	safety	NOUN
dpc-4871	37	14	of	of	ADP
dpc-4871	37	15	another	another	DET
dpc-4871	37	16	il-36	il-36	NOUN
dpc-4871	37	17	receptor	receptor	NOUN
dpc-4871	37	18	inhibitor	inhibitor	NOUN
dpc-4871	37	19	,	,	PUNCT
dpc-4871	37	20	imsidolimab	imsidolimab	NOUN
dpc-4871	37	21	,	,	PUNCT
dpc-4871	37	22	in	in	ADP
dpc-4871	37	23	both	both	DET
dpc-4871	37	24	gpp	gpp	NOUN
dpc-4871	37	25	and	and	CCONJ
dpc-4871	37	26	ppp	ppp	PROPN
dpc-4871	37	27	p	p	NOUN
dpc-4871	37	28	atients	atient	NOUN
dpc-4871	38	1	[	[	X
dpc-4871	38	2	12	12	NUM
dpc-4871	38	3	]	]	PUNCT
dpc-4871	38	4	.	.	PUNCT
dpc-4871	39	1	so	so	ADV
dpc-4871	39	2	far	far	ADV
dpc-4871	39	3	,	,	PUNCT
dpc-4871	39	4	a	a	DET
dpc-4871	39	5	phase	phase	NOUN
dpc-4871	39	6	1	1	NUM
dpc-4871	39	7	study	study	NOUN
dpc-4871	39	8	suggested	suggest	VERB
dpc-4871	39	9	a	a	DET
dpc-4871	39	10	favorable	favorable	ADJ
dpc-4871	39	11	side	side	NOUN
dpc-4871	39	12	effect	effect	NOUN
dpc-4871	39	13	profile	profile	NOUN
dpc-4871	39	14	for	for	ADP
dpc-4871	39	15	this	this	DET
dpc-4871	39	16	new	new	ADJ
dpc-4871	39	17	therapeutic	therapeutic	ADJ
dpc-4871	39	18	candidate	candidate	NOUN
dpc-4871	39	19	[	[	X
dpc-4871	39	20	13	13	NUM
dpc-4871	39	21	]	]	PUNCT
dpc-4871	39	22	.	.	PUNCT
dpc-4871	40	1	objectives	objective	NOUN
dpc-4871	40	2	in	in	ADP
dpc-4871	40	3	light	light	NOUN
dpc-4871	40	4	of	of	ADP
dpc-4871	40	5	the	the	DET
dpc-4871	40	6	evidence	evidence	NOUN
dpc-4871	40	7	,	,	PUNCT
dpc-4871	40	8	we	we	PRON
dpc-4871	40	9	aimed	aim	VERB
dpc-4871	40	10	to	to	PART
dpc-4871	40	11	explore	explore	VERB
dpc-4871	40	12	the	the	DET
dpc-4871	40	13	current	current	ADJ
dpc-4871	40	14	real	real	ADJ
dpc-4871	40	15	-	-	PUNCT
dpc-4871	40	16	life	life	NOUN
dpc-4871	40	17	therapeutic	therapeutic	ADJ
dpc-4871	40	18	management	management	NOUN
dpc-4871	40	19	of	of	ADP
dpc-4871	40	20	pp	pp	ADV
dpc-4871	40	21	and	and	CCONJ
dpc-4871	40	22	its	its	PRON
dpc-4871	40	23	correlation	correlation	NOUN
dpc-4871	40	24	with	with	ADP
dpc-4871	40	25	patient	patient	ADJ
dpc-4871	40	26	qol	qol	PROPN
dpc-4871	40	27	scores	score	NOUN
dpc-4871	40	28	.	.	PUNCT
dpc-4871	41	1	methods	method	NOUN
dpc-4871	41	2	patients	patient	NOUN
dpc-4871	41	3	this	this	DET
dpc-4871	41	4	noninterventional	noninterventional	NOUN
dpc-4871	41	5	,	,	PUNCT
dpc-4871	41	6	cross	cross	ADJ
dpc-4871	41	7	-	-	ADJ
dpc-4871	41	8	sectional	sectional	ADJ
dpc-4871	41	9	study	study	NOUN
dpc-4871	41	10	was	be	AUX
dpc-4871	41	11	performed	perform	VERB
dpc-4871	41	12	using	use	VERB
dpc-4871	41	13	a	a	DET
dpc-4871	41	14	database	database	NOUN
dpc-4871	41	15	in	in	ADP
dpc-4871	41	16	which	which	PRON
dpc-4871	41	17	adult	adult	NOUN
dpc-4871	41	18	patients	patient	NOUN
dpc-4871	41	19	with	with	ADP
dpc-4871	41	20	pustular	pustular	ADJ
dpc-4871	41	21	psoriasis	psoriasis	NOUN
dpc-4871	41	22	were	be	AUX
dpc-4871	41	23	included	include	VERB
dpc-4871	41	24	.	.	PUNCT
dpc-4871	42	1	inclusion	inclusion	NOUN
dpc-4871	42	2	criteria	criterion	NOUN
dpc-4871	42	3	were	be	AUX
dpc-4871	42	4	represented	represent	VERB
dpc-4871	42	5	by	by	ADP
dpc-4871	42	6	patients	patient	NOUN
dpc-4871	42	7	with	with	ADP
dpc-4871	42	8	a	a	DET
dpc-4871	42	9	confirmed	confirm	VERB
dpc-4871	42	10	diagnosis	diagnosis	NOUN
dpc-4871	42	11	of	of	ADP
dpc-4871	42	12	pp	pp	ADP
dpc-4871	42	13	having	having	AUX
dpc-4871	42	14	performed	perform	VERB
dpc-4871	42	15	visits	visit	NOUN
dpc-4871	42	16	from	from	ADP
dpc-4871	42	17	2017	2017	NUM
dpc-4871	42	18	to	to	ADP
dpc-4871	42	19	2021	2021	NUM
dpc-4871	42	20	and	and	CCONJ
dpc-4871	42	21	at	at	ADP
dpc-4871	42	22	least	least	ADJ
dpc-4871	42	23	a	a	DET
dpc-4871	42	24	follow	follow	NOUN
dpc-4871	42	25	-	-	PUNCT
dpc-4871	42	26	up	up	NOUN
dpc-4871	42	27	during	during	ADP
dpc-4871	42	28	2021	2021	NUM
dpc-4871	42	29	.	.	PUNCT
dpc-4871	43	1	the	the	DET
dpc-4871	43	2	study	study	NOUN
dpc-4871	43	3	protocol	protocol	NOUN
dpc-4871	43	4	was	be	AUX
dpc-4871	43	5	performed	perform	VERB
dpc-4871	43	6	in	in	ADP
dpc-4871	43	7	accordance	accordance	NOUN
dpc-4871	43	8	with	with	ADP
dpc-4871	43	9	the	the	DET
dpc-4871	43	10	ethical	ethical	ADJ
dpc-4871	43	11	standards	standard	NOUN
dpc-4871	43	12	of	of	ADP
dpc-4871	43	13	the	the	DET
dpc-4871	43	14	institutional	institutional	ADJ
dpc-4871	43	15	and/or	and/or	CCONJ
dpc-4871	43	16	national	national	PROPN
dpc-4871	43	17	research	research	PROPN
dpc-4871	43	18	committee	committee	NOUN
dpc-4871	43	19	and	and	CCONJ
dpc-4871	43	20	with	with	ADP
dpc-4871	43	21	the	the	DET
dpc-4871	43	22	1964	1964	NUM
dpc-4871	43	23	helsinki	helsinki	PROPN
dpc-4871	43	24	declaration	declaration	PROPN
dpc-4871	43	25	and	and	CCONJ
dpc-4871	43	26	its	its	PRON
dpc-4871	43	27	later	later	ADJ
dpc-4871	43	28	amendments	amendment	NOUN
dpc-4871	43	29	or	or	CCONJ
dpc-4871	43	30	comparable	comparable	ADJ
dpc-4871	43	31	ethical	ethical	ADJ
dpc-4871	43	32	standards	standard	NOUN
dpc-4871	43	33	.	.	PUNCT
dpc-4871	44	1	each	each	DET
dpc-4871	44	2	participant	participant	NOUN
dpc-4871	44	3	gave	gave	AUX
dpc-4871	44	4	written	write	VERB
dpc-4871	44	5	informed	informed	ADJ
dpc-4871	44	6	consent	consent	NOUN
dpc-4871	44	7	before	before	ADP
dpc-4871	44	8	the	the	DET
dpc-4871	44	9	onset	onset	NOUN
dpc-4871	44	10	of	of	ADP
dpc-4871	44	11	the	the	DET
dpc-4871	44	12	study	study	NOUN
dpc-4871	44	13	.	.	PUNCT
dpc-4871	45	1	data	datum	NOUN
dpc-4871	45	2	a	a	DET
dpc-4871	45	3	spreadsheet	spreadsheet	NOUN
dpc-4871	45	4	was	be	AUX
dpc-4871	45	5	created	create	VERB
dpc-4871	45	6	from	from	ADP
dpc-4871	45	7	available	available	ADJ
dpc-4871	45	8	past	past	ADJ
dpc-4871	45	9	data	datum	NOUN
dpc-4871	45	10	of	of	ADP
dpc-4871	45	11	patients	patient	NOUN
dpc-4871	45	12	’	'	PUNCT
dpc-4871	45	13	medical	medical	ADJ
dpc-4871	45	14	files	file	NOUN
dpc-4871	45	15	.	.	PUNCT
dpc-4871	46	1	the	the	DET
dpc-4871	46	2	analysis	analysis	NOUN
dpc-4871	46	3	was	be	AUX
dpc-4871	46	4	performed	perform	VERB
dpc-4871	46	5	in	in	ADP
dpc-4871	46	6	march	march	PROPN
dpc-4871	46	7	2022	2022	NUM
dpc-4871	46	8	.	.	PUNCT
dpc-4871	47	1	we	we	PRON
dpc-4871	47	2	collected	collect	VERB
dpc-4871	47	3	data	datum	NOUN
dpc-4871	47	4	on	on	ADP
dpc-4871	47	5	age	age	NOUN
dpc-4871	47	6	,	,	PUNCT
dpc-4871	47	7	sex	sex	NOUN
dpc-4871	47	8	,	,	PUNCT
dpc-4871	47	9	medical	medical	ADJ
dpc-4871	47	10	history	history	NOUN
dpc-4871	47	11	,	,	PUNCT
dpc-4871	47	12	clinical	clinical	ADJ
dpc-4871	47	13	scores	score	NOUN
dpc-4871	47	14	,	,	PUNCT
dpc-4871	47	15	qol	qol	PROPN
dpc-4871	47	16	scores	score	NOUN
dpc-4871	47	17	.	.	PUNCT
dpc-4871	48	1	the	the	DET
dpc-4871	48	2	severity	severity	NOUN
dpc-4871	48	3	of	of	ADP
dpc-4871	48	4	the	the	DET
dpc-4871	48	5	disease	disease	NOUN
dpc-4871	48	6	was	be	AUX
dpc-4871	48	7	defined	define	VERB
dpc-4871	48	8	as	as	ADP
dpc-4871	48	9	the	the	DET
dpc-4871	48	10	last	last	ADJ
dpc-4871	48	11	clinical	clinical	ADJ
dpc-4871	48	12	score	score	NOUN
dpc-4871	48	13	recorded	record	VERB
dpc-4871	48	14	in	in	ADP
dpc-4871	48	15	the	the	DET
dpc-4871	48	16	database	database	NOUN
dpc-4871	48	17	.	.	PUNCT
dpc-4871	49	1	for	for	ADP
dpc-4871	49	2	gpp	gpp	NOUN
dpc-4871	49	3	+	+	CCONJ
dpc-4871	49	4	pso	pso	NOUN
dpc-4871	49	5	,	,	PUNCT
dpc-4871	49	6	when	when	SCONJ
dpc-4871	49	7	the	the	DET
dpc-4871	49	8	generalized	generalized	ADJ
dpc-4871	49	9	pustular	pustular	ADJ
dpc-4871	49	10	psoriasis	psoriasis	NOUN
dpc-4871	49	11	area	area	NOUN
dpc-4871	49	12	severity	severity	NOUN
dpc-4871	49	13	index	index	NOUN
dpc-4871	49	14	(	(	PUNCT
dpc-4871	49	15	gppasi	gppasi	PROPN
dpc-4871	49	16	)	)	PUNCT
dpc-4871	49	17	was	be	AUX
dpc-4871	49	18	≥	≥	NOUN
dpc-4871	49	19	2.5	2.5	NUM
dpc-4871	49	20	,	,	PUNCT
dpc-4871	49	21	the	the	DET
dpc-4871	49	22	disease	disease	NOUN
dpc-4871	49	23	was	be	AUX
dpc-4871	49	24	considered	consider	VERB
dpc-4871	49	25	moderate	moderate	ADJ
dpc-4871	49	26	-	-	PUNCT
dpc-4871	49	27	to	to	ADP
dpc-4871	49	28	-	-	PUNCT
dpc-4871	49	29	severe	severe	ADJ
dpc-4871	49	30	[	[	X
dpc-4871	49	31	14	14	NUM
dpc-4871	49	32	]	]	PUNCT
dpc-4871	49	33	.	.	PUNCT
dpc-4871	50	1	for	for	ADP
dpc-4871	50	2	ppp	ppp	PROPN
dpc-4871	50	3	,	,	PUNCT
dpc-4871	50	4	the	the	DET
dpc-4871	50	5	guidelines	guideline	NOUN
dpc-4871	50	6	defined	define	VERB
dpc-4871	50	7	a	a	DET
dpc-4871	50	8	moderate	moderate	ADJ
dpc-4871	50	9	-	-	PUNCT
dpc-4871	50	10	to	to	ADP
dpc-4871	50	11	-	-	PUNCT
dpc-4871	50	12	severe	severe	ADJ
dpc-4871	50	13	ppp	ppp	NOUN
dpc-4871	50	14	by	by	ADP
dpc-4871	50	15	the	the	DET
dpc-4871	50	16	palmoplantar	palmoplantar	NOUN
dpc-4871	50	17	pustulosis	pustulosis	PROPN
dpc-4871	50	18	area	area	NOUN
dpc-4871	50	19	severity	severity	NOUN
dpc-4871	50	20	index	index	NOUN
dpc-4871	50	21	(	(	PUNCT
dpc-4871	50	22	pppasi	pppasi	PROPN
dpc-4871	50	23	)	)	PUNCT
dpc-4871	50	24	≥	≥	NOUN
dpc-4871	50	25	2.5	2.5	NUM
dpc-4871	51	1	[	[	X
dpc-4871	51	2	15	15	NUM
dpc-4871	51	3	]	]	PUNCT
dpc-4871	51	4	.	.	PUNCT
dpc-4871	52	1	finally	finally	ADV
dpc-4871	52	2	,	,	PUNCT
dpc-4871	52	3	a	a	DET
dpc-4871	52	4	dermatology	dermatology	NOUN
dpc-4871	52	5	life	life	NOUN
dpc-4871	52	6	quality	quality	NOUN
dpc-4871	52	7	index	index	NOUN
dpc-4871	52	8	(	(	PUNCT
dpc-4871	52	9	dlqi	dlqi	ADJ
dpc-4871	52	10	)	)	PUNCT
dpc-4871	52	11	score	score	NOUN
dpc-4871	52	12	≥10	≥10	PROPN
dpc-4871	52	13	referred	refer	VERB
dpc-4871	52	14	to	to	ADP
dpc-4871	52	15	a	a	DET
dpc-4871	52	16	significant	significant	ADJ
dpc-4871	52	17	impact	impact	NOUN
dpc-4871	52	18	of	of	ADP
dpc-4871	52	19	the	the	DET
dpc-4871	52	20	disease	disease	NOUN
dpc-4871	52	21	on	on	ADP
dpc-4871	52	22	qol	qol	PROPN
dpc-4871	53	1	[	[	X
dpc-4871	53	2	16	16	NUM
dpc-4871	53	3	]	]	PUNCT
dpc-4871	53	4	.	.	PUNCT
dpc-4871	54	1	therapeutic	therapeutic	ADJ
dpc-4871	54	2	results	result	NOUN
dpc-4871	54	3	:	:	PUNCT
dpc-4871	54	4	gpp	gpp	NOUN
dpc-4871	54	5	+	+	CCONJ
dpc-4871	54	6	pso	pso	NOUN
dpc-4871	54	7	patients	patient	NOUN
dpc-4871	54	8	with	with	ADP
dpc-4871	54	9	an	an	DET
dpc-4871	54	10	impaired	impaired	ADJ
dpc-4871	54	11	qol	qol	NOUN
dpc-4871	54	12	(	(	PUNCT
dpc-4871	54	13	dlqi≥10	dlqi≥10	NOUN
dpc-4871	54	14	)	)	PUNCT
dpc-4871	54	15	were	be	AUX
dpc-4871	54	16	associated	associate	VERB
dpc-4871	54	17	with	with	ADP
dpc-4871	54	18	biological	biological	ADJ
dpc-4871	54	19	therapy	therapy	NOUN
dpc-4871	54	20	including	include	VERB
dpc-4871	54	21	certolizumab	certolizumab	NOUN
dpc-4871	54	22	(	(	PUNCT
dpc-4871	54	23	odds	odd	NOUN
dpc-4871	54	24	ratio	ratio	NOUN
dpc-4871	54	25	[	[	X
dpc-4871	54	26	or]=2.38	or]=2.38	X
dpc-4871	54	27	)	)	PUNCT
dpc-4871	54	28	,	,	PUNCT
dpc-4871	54	29	etanercept	etanercept	NOUN
dpc-4871	54	30	(	(	PUNCT
dpc-4871	54	31	or=2.25	or=2.25	NOUN
dpc-4871	54	32	)	)	PUNCT
dpc-4871	54	33	,	,	PUNCT
dpc-4871	54	34	secukinumab	secukinumab	NOUN
dpc-4871	54	35	(	(	PUNCT
dpc-4871	54	36	or=2.03	or=2.03	NOUN
dpc-4871	54	37	)	)	PUNCT
dpc-4871	54	38	or	or	CCONJ
dpc-4871	54	39	ustekinumab	ustekinumab	NOUN
dpc-4871	54	40	(	(	PUNCT
dpc-4871	54	41	or=2.79	or=2.79	ADJ
dpc-4871	54	42	)	)	PUNCT
dpc-4871	54	43	whereas	whereas	ADV
dpc-4871	54	44	,	,	PUNCT
dpc-4871	54	45	ppp	ppp	NOUN
dpc-4871	54	46	patients	patient	NOUN
dpc-4871	54	47	were	be	AUX
dpc-4871	54	48	positively	positively	ADV
dpc-4871	54	49	associated	associate	VERB
dpc-4871	54	50	with	with	ADP
dpc-4871	54	51	secukinumab	secukinumab	NOUN
dpc-4871	54	52	(	(	PUNCT
dpc-4871	54	53	or=2.85	or=2.85	PROPN
dpc-4871	54	54	)	)	PUNCT
dpc-4871	54	55	or	or	CCONJ
dpc-4871	54	56	apremilast	apremilast	VERB
dpc-4871	54	57	(	(	PUNCT
dpc-4871	54	58	or	or	CCONJ
dpc-4871	54	59	4.28	4.28	NUM
dpc-4871	54	60	,	,	PUNCT
dpc-4871	54	61	95%-ci	95%-ci	NUM
dpc-4871	54	62	0.56	0.56	NUM
dpc-4871	54	63	-	-	SYM
dpc-4871	54	64	9.62	9.62	NUM
dpc-4871	54	65	)	)	PUNCT
dpc-4871	54	66	.	.	PUNCT
dpc-4871	55	1	conclusions	conclusion	NOUN
dpc-4871	55	2	:	:	PUNCT
dpc-4871	55	3	currently	currently	ADV
dpc-4871	55	4	,	,	PUNCT
dpc-4871	55	5	systemic	systemic	ADJ
dpc-4871	55	6	conventional	conventional	ADJ
dpc-4871	55	7	therapy	therapy	NOUN
dpc-4871	55	8	remains	remain	VERB
dpc-4871	55	9	the	the	DET
dpc-4871	55	10	therapeutic	therapeutic	ADJ
dpc-4871	55	11	fulcrum	fulcrum	NOUN
dpc-4871	55	12	of	of	ADP
dpc-4871	55	13	pp	pp	PROPN
dpc-4871	55	14	management	management	NOUN
dpc-4871	55	15	.	.	PUNCT
dpc-4871	56	1	a	a	DET
dpc-4871	56	2	great	great	ADJ
dpc-4871	56	3	effect	effect	NOUN
dpc-4871	56	4	on	on	ADP
dpc-4871	56	5	qol	qol	NOUN
dpc-4871	56	6	,	,	PUNCT
dpc-4871	56	7	especially	especially	ADV
dpc-4871	56	8	for	for	ADP
dpc-4871	56	9	gpp+pso	gpp+pso	NOUN
dpc-4871	56	10	,	,	PUNCT
dpc-4871	56	11	was	be	AUX
dpc-4871	56	12	assessed	assess	VERB
dpc-4871	56	13	regardless	regardless	ADV
dpc-4871	56	14	the	the	DET
dpc-4871	56	15	ongoing	ongoing	ADJ
dpc-4871	56	16	treatment	treatment	NOUN
dpc-4871	56	17	and	and	CCONJ
dpc-4871	56	18	only	only	ADV
dpc-4871	56	19	newer	new	ADJ
dpc-4871	56	20	biologic	biologic	NOUN
dpc-4871	56	21	options	option	NOUN
dpc-4871	56	22	were	be	AUX
dpc-4871	56	23	able	able	ADJ
dpc-4871	56	24	to	to	PART
dpc-4871	56	25	somehow	somehow	ADV
dpc-4871	56	26	positively	positively	ADV
dpc-4871	56	27	impact	impact	VERB
dpc-4871	56	28	.	.	PUNCT
dpc-4871	57	1	original	original	ADJ
dpc-4871	57	2	article	article	NOUN
dpc-4871	57	3	|	|	ADV
dpc-4871	57	4	dermatol	dermatol	ADJ
dpc-4871	57	5	pract	pract	NOUN
dpc-4871	57	6	concept	concept	NOUN
dpc-4871	57	7	.	.	PUNCT
dpc-4871	58	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	58	2	3	3	NUM
dpc-4871	58	3	data	datum	NOUN
dpc-4871	58	4	concerned	concern	VERB
dpc-4871	58	5	systemic	systemic	ADJ
dpc-4871	58	6	treatments	treatment	NOUN
dpc-4871	58	7	commercially	commercially	ADV
dpc-4871	58	8	available	available	ADJ
dpc-4871	58	9	in	in	ADP
dpc-4871	58	10	italy	italy	PROPN
dpc-4871	58	11	,	,	PUNCT
dpc-4871	58	12	including	include	VERB
dpc-4871	58	13	conventional	conventional	ADJ
dpc-4871	58	14	and	and	CCONJ
dpc-4871	58	15	biological	biological	ADJ
dpc-4871	58	16	therapies	therapy	NOUN
dpc-4871	58	17	.	.	PUNCT
dpc-4871	59	1	statistical	statistical	ADJ
dpc-4871	59	2	analysis	analysis	NOUN
dpc-4871	59	3	collected	collect	VERB
dpc-4871	59	4	variables	variable	NOUN
dpc-4871	59	5	were	be	AUX
dpc-4871	59	6	described	describe	VERB
dpc-4871	59	7	with	with	ADP
dpc-4871	59	8	number	number	NOUN
dpc-4871	59	9	and	and	CCONJ
dpc-4871	59	10	percentage	percentage	NOUN
dpc-4871	59	11	for	for	ADP
dpc-4871	59	12	categorical	categorical	ADJ
dpc-4871	59	13	variables	variable	NOUN
dpc-4871	59	14	,	,	PUNCT
dpc-4871	59	15	and	and	CCONJ
dpc-4871	59	16	mean	mean	VERB
dpc-4871	59	17	,	,	PUNCT
dpc-4871	59	18	range	range	NOUN
dpc-4871	59	19	and	and	CCONJ
dpc-4871	59	20	standard	standard	ADJ
dpc-4871	59	21	deviation	deviation	NOUN
dpc-4871	59	22	for	for	ADP
dpc-4871	59	23	continuous	continuous	ADJ
dpc-4871	59	24	data	datum	NOUN
dpc-4871	59	25	.	.	PUNCT
dpc-4871	60	1	we	we	PRON
dpc-4871	60	2	focused	focus	VERB
dpc-4871	60	3	on	on	ADP
dpc-4871	60	4	comparing	compare	VERB
dpc-4871	60	5	the	the	DET
dpc-4871	60	6	current	current	ADJ
dpc-4871	60	7	therapies	therapy	NOUN
dpc-4871	60	8	associated	associate	VERB
dpc-4871	60	9	with	with	ADP
dpc-4871	60	10	qol	qol	PROPN
dpc-4871	60	11	scores	score	NOUN
dpc-4871	60	12	in	in	ADP
dpc-4871	60	13	gpp	gpp	NOUN
dpc-4871	60	14	+	+	CCONJ
dpc-4871	60	15	pso	pso	NOUN
dpc-4871	60	16	and	and	CCONJ
dpc-4871	60	17	ppp	ppp	NOUN
dpc-4871	60	18	patients	patient	NOUN
dpc-4871	60	19	.	.	PUNCT
dpc-4871	61	1	therefore	therefore	ADV
dpc-4871	61	2	,	,	PUNCT
dpc-4871	61	3	we	we	PRON
dpc-4871	61	4	adjusted	adjust	VERB
dpc-4871	61	5	and	and	CCONJ
dpc-4871	61	6	controlled	control	VERB
dpc-4871	61	7	for	for	ADP
dpc-4871	61	8	dlqi	dlqi	ADJ
dpc-4871	61	9	categories	category	NOUN
dpc-4871	61	10	(	(	PUNCT
dpc-4871	61	11	<	<	X
dpc-4871	61	12	10	10	NUM
dpc-4871	61	13	and	and	CCONJ
dpc-4871	61	14	≥10	≥10	ADJ
dpc-4871	61	15	)	)	PUNCT
dpc-4871	61	16	by	by	ADP
dpc-4871	61	17	calculating	calculate	VERB
dpc-4871	61	18	odds	odd	NOUN
dpc-4871	61	19	ratios	ratio	NOUN
dpc-4871	61	20	(	(	PUNCT
dpc-4871	61	21	ors	or	NOUN
dpc-4871	61	22	)	)	PUNCT
dpc-4871	61	23	and	and	CCONJ
dpc-4871	61	24	95	95	NUM
dpc-4871	61	25	%	%	NOUN
dpc-4871	61	26	confidence	confidence	NOUN
dpc-4871	61	27	intervals	interval	NOUN
dpc-4871	61	28	(	(	PUNCT
dpc-4871	61	29	cis	cis	NOUN
dpc-4871	61	30	)	)	PUNCT
dpc-4871	61	31	for	for	ADP
dpc-4871	61	32	each	each	DET
dpc-4871	61	33	current	current	ADJ
dpc-4871	61	34	treatment	treatment	NOUN
dpc-4871	61	35	.	.	PUNCT
dpc-4871	62	1	variables	variable	NOUN
dpc-4871	62	2	with	with	ADP
dpc-4871	62	3	ors	or	NOUN
dpc-4871	62	4	<	<	X
dpc-4871	62	5	1	1	NUM
dpc-4871	62	6	were	be	AUX
dpc-4871	62	7	interpreted	interpret	VERB
dpc-4871	62	8	as	as	ADP
dpc-4871	62	9	negative	negative	ADJ
dpc-4871	62	10	factors	factor	NOUN
dpc-4871	62	11	,	,	PUNCT
dpc-4871	62	12	ors=1	ors=1	INTJ
dpc-4871	62	13	as	as	ADP
dpc-4871	62	14	non	non	ADJ
dpc-4871	62	15	-	-	ADJ
dpc-4871	62	16	associated	associated	ADJ
dpc-4871	62	17	factors	factor	NOUN
dpc-4871	62	18	whereas	whereas	SCONJ
dpc-4871	62	19	ors	or	NOUN
dpc-4871	62	20	>	>	X
dpc-4871	62	21	1	1	NUM
dpc-4871	62	22	as	as	ADP
dpc-4871	62	23	positive	positive	ADJ
dpc-4871	62	24	factors	factor	NOUN
dpc-4871	62	25	.	.	PUNCT
dpc-4871	63	1	to	to	PART
dpc-4871	63	2	calculate	calculate	VERB
dpc-4871	63	3	statistical	statistical	ADJ
dpc-4871	63	4	differences	difference	NOUN
dpc-4871	63	5	,	,	PUNCT
dpc-4871	63	6	we	we	PRON
dpc-4871	63	7	performed	perform	VERB
dpc-4871	63	8	χ2	χ2	PROPN
dpc-4871	63	9	test	test	NOUN
dpc-4871	63	10	or	or	CCONJ
dpc-4871	63	11	the	the	DET
dpc-4871	63	12	fisher	fisher	PROPN
dpc-4871	63	13	exact	exact	ADJ
dpc-4871	63	14	test	test	NOUN
dpc-4871	63	15	,	,	PUNCT
dpc-4871	63	16	as	as	ADP
dpc-4871	63	17	appropriate	appropriate	ADJ
dpc-4871	63	18	.	.	PUNCT
dpc-4871	64	1	two	two	NUM
dpc-4871	64	2	-	-	PUNCT
dpc-4871	64	3	sided	side	VERB
dpc-4871	64	4	p	p	NOUN
dpc-4871	64	5	values	value	NOUN
dpc-4871	64	6	below	below	ADP
dpc-4871	64	7	0.05	0.05	NUM
dpc-4871	64	8	were	be	AUX
dpc-4871	64	9	considered	consider	VERB
dpc-4871	64	10	significant	significant	ADJ
dpc-4871	64	11	.	.	PUNCT
dpc-4871	65	1	results	result	NOUN
dpc-4871	65	2	patient	patient	ADJ
dpc-4871	65	3	characteristics	characteristic	NOUN
dpc-4871	65	4	a	a	DET
dpc-4871	65	5	total	total	NOUN
dpc-4871	65	6	of	of	ADP
dpc-4871	65	7	108	108	NUM
dpc-4871	65	8	patients	patient	NOUN
dpc-4871	65	9	were	be	AUX
dpc-4871	65	10	included	include	VERB
dpc-4871	65	11	,	,	PUNCT
dpc-4871	65	12	comprising	comprise	VERB
dpc-4871	65	13	62	62	NUM
dpc-4871	65	14	gpp	gpp	NOUN
dpc-4871	65	15	+	+	CCONJ
dpc-4871	65	16	pso	pso	NOUN
dpc-4871	65	17	and	and	CCONJ
dpc-4871	65	18	46	46	NUM
dpc-4871	65	19	ppp	ppp	NOUN
dpc-4871	65	20	patients	patient	NOUN
dpc-4871	65	21	.	.	PUNCT
dpc-4871	66	1	for	for	ADP
dpc-4871	66	2	gpp	gpp	NOUN
dpc-4871	66	3	+	+	CCONJ
dpc-4871	66	4	pso	pso	NOUN
dpc-4871	66	5	,	,	PUNCT
dpc-4871	66	6	the	the	DET
dpc-4871	66	7	localization	localization	NOUN
dpc-4871	66	8	of	of	ADP
dpc-4871	66	9	plaque	plaque	NOUN
dpc-4871	66	10	psoriasis	psoriasis	NOUN
dpc-4871	66	11	was	be	AUX
dpc-4871	66	12	assessed	assess	VERB
dpc-4871	66	13	on	on	ADP
dpc-4871	66	14	nails	nail	NOUN
dpc-4871	66	15	(	(	PUNCT
dpc-4871	66	16	29.5	29.5	NUM
dpc-4871	66	17	%	%	NOUN
dpc-4871	66	18	,	,	PUNCT
dpc-4871	66	19	n	n	NOUN
dpc-4871	66	20	=	=	SYM
dpc-4871	66	21	18	18	NUM
dpc-4871	66	22	)	)	PUNCT
dpc-4871	66	23	,	,	PUNCT
dpc-4871	66	24	upper	upper	ADJ
dpc-4871	66	25	extremities	extremity	NOUN
dpc-4871	66	26	(	(	PUNCT
dpc-4871	66	27	27.4	27.4	NUM
dpc-4871	66	28	%	%	NOUN
dpc-4871	66	29	,	,	PUNCT
dpc-4871	66	30	n	n	PROPN
dpc-4871	66	31	=	=	SYM
dpc-4871	66	32	17	17	NUM
dpc-4871	66	33	)	)	PUNCT
dpc-4871	66	34	,	,	PUNCT
dpc-4871	66	35	scalp	scalp	NOUN
dpc-4871	66	36	(	(	PUNCT
dpc-4871	66	37	22.6	22.6	NUM
dpc-4871	66	38	%	%	NOUN
dpc-4871	66	39	,	,	PUNCT
dpc-4871	66	40	n	n	NOUN
dpc-4871	66	41	=	=	SYM
dpc-4871	66	42	14	14	NUM
dpc-4871	66	43	)	)	PUNCT
dpc-4871	66	44	,	,	PUNCT
dpc-4871	66	45	trunk	trunk	NOUN
dpc-4871	66	46	(	(	PUNCT
dpc-4871	66	47	14.5	14.5	NUM
dpc-4871	66	48	%	%	NOUN
dpc-4871	66	49	,	,	PUNCT
dpc-4871	66	50	n	n	NOUN
dpc-4871	66	51	=	=	NOUN
dpc-4871	66	52	9	9	NUM
dpc-4871	66	53	)	)	PUNCT
dpc-4871	66	54	,	,	PUNCT
dpc-4871	66	55	and	and	CCONJ
dpc-4871	66	56	lower	low	ADJ
dpc-4871	66	57	extremities	extremity	NOUN
dpc-4871	66	58	(	(	PUNCT
dpc-4871	66	59	12.9	12.9	NUM
dpc-4871	66	60	%	%	NOUN
dpc-4871	66	61	,	,	PUNCT
dpc-4871	66	62	n	n	PROPN
dpc-4871	66	63	=	=	SYM
dpc-4871	66	64	8)	8)	NUM
dpc-4871	66	65	.	.	PUNCT
dpc-4871	67	1	other	other	ADJ
dpc-4871	67	2	lesions	lesion	NOUN
dpc-4871	67	3	were	be	AUX
dpc-4871	67	4	located	locate	VERB
dpc-4871	67	5	on	on	ADP
dpc-4871	67	6	genitals	genital	NOUN
dpc-4871	67	7	(	(	PUNCT
dpc-4871	67	8	6.4	6.4	NUM
dpc-4871	67	9	%	%	NOUN
dpc-4871	67	10	,	,	PUNCT
dpc-4871	67	11	n	n	NOUN
dpc-4871	67	12	=	=	SYM
dpc-4871	67	13	4	4	NUM
dpc-4871	67	14	)	)	PUNCT
dpc-4871	67	15	,	,	PUNCT
dpc-4871	67	16	face	face	NOUN
dpc-4871	67	17	(	(	PUNCT
dpc-4871	67	18	4.8	4.8	NUM
dpc-4871	67	19	%	%	NOUN
dpc-4871	67	20	,	,	PUNCT
dpc-4871	67	21	n	n	NOUN
dpc-4871	67	22	=	=	SYM
dpc-4871	67	23	3	3	NUM
dpc-4871	67	24	)	)	PUNCT
dpc-4871	67	25	or	or	CCONJ
dpc-4871	67	26	intertriginous	intertriginous	ADJ
dpc-4871	67	27	regions	region	NOUN
dpc-4871	67	28	(	(	PUNCT
dpc-4871	67	29	4.8	4.8	NUM
dpc-4871	67	30	%	%	NOUN
dpc-4871	67	31	,	,	PUNCT
dpc-4871	67	32	n	n	NOUN
dpc-4871	67	33	=	=	SYM
dpc-4871	67	34	3	3	NUM
dpc-4871	67	35	)	)	PUNCT
dpc-4871	67	36	(	(	PUNCT
dpc-4871	67	37	data	datum	NOUN
dpc-4871	67	38	not	not	PART
dpc-4871	67	39	shown	show	VERB
dpc-4871	67	40	)	)	PUNCT
dpc-4871	67	41	.	.	PUNCT
dpc-4871	68	1	women	woman	NOUN
dpc-4871	68	2	represented	represent	VERB
dpc-4871	68	3	the	the	DET
dpc-4871	68	4	majority	majority	NOUN
dpc-4871	68	5	of	of	ADP
dpc-4871	68	6	gpp	gpp	NOUN
dpc-4871	68	7	+	+	CCONJ
dpc-4871	68	8	pso	pso	NOUN
dpc-4871	68	9	,	,	PUNCT
dpc-4871	68	10	inversely	inversely	ADV
dpc-4871	68	11	to	to	ADP
dpc-4871	68	12	ppp	ppp	PROPN
dpc-4871	68	13	.	.	PUNCT
dpc-4871	69	1	data	datum	NOUN
dpc-4871	69	2	regarding	regard	VERB
dpc-4871	69	3	sex	sex	NOUN
dpc-4871	69	4	,	,	PUNCT
dpc-4871	69	5	age	age	NOUN
dpc-4871	69	6	,	,	PUNCT
dpc-4871	69	7	body	body	NOUN
dpc-4871	69	8	mass	mass	NOUN
dpc-4871	69	9	index	index	NOUN
dpc-4871	69	10	(	(	PUNCT
dpc-4871	69	11	bmi	bmi	PROPN
dpc-4871	69	12	)	)	PUNCT
dpc-4871	69	13	,	,	PUNCT
dpc-4871	69	14	comorbidities	comorbiditie	NOUN
dpc-4871	69	15	,	,	PUNCT
dpc-4871	69	16	previous	previous	ADJ
dpc-4871	69	17	and	and	CCONJ
dpc-4871	69	18	current	current	ADJ
dpc-4871	69	19	therapies	therapy	NOUN
dpc-4871	69	20	are	be	AUX
dpc-4871	69	21	summarized	summarize	VERB
dpc-4871	69	22	in	in	ADP
dpc-4871	69	23	table	table	NOUN
dpc-4871	69	24	1	1	NUM
dpc-4871	69	25	.	.	PUNCT
dpc-4871	70	1	therapeutic	therapeutic	ADJ
dpc-4871	70	2	management	management	NOUN
dpc-4871	70	3	systemic	systemic	ADJ
dpc-4871	70	4	non	non	ADJ
dpc-4871	70	5	-	-	ADJ
dpc-4871	70	6	biological	biological	ADJ
dpc-4871	70	7	therapy	therapy	NOUN
dpc-4871	70	8	resulted	result	VERB
dpc-4871	70	9	to	to	PART
dpc-4871	70	10	be	be	AUX
dpc-4871	70	11	the	the	DET
dpc-4871	70	12	first	first	ADJ
dpc-4871	70	13	-	-	PUNCT
dpc-4871	70	14	line	line	NOUN
dpc-4871	70	15	treatment	treatment	NOUN
dpc-4871	70	16	for	for	ADP
dpc-4871	70	17	both	both	DET
dpc-4871	70	18	groups	group	NOUN
dpc-4871	70	19	despite	despite	SCONJ
dpc-4871	70	20	the	the	DET
dpc-4871	70	21	availability	availability	NOUN
dpc-4871	70	22	of	of	ADP
dpc-4871	70	23	the	the	DET
dpc-4871	70	24	newest	new	ADJ
dpc-4871	70	25	biological	biological	ADJ
dpc-4871	70	26	treatment	treatment	NOUN
dpc-4871	70	27	options	option	NOUN
dpc-4871	70	28	(	(	PUNCT
dpc-4871	70	29	table	table	NOUN
dpc-4871	70	30	2	2	NUM
dpc-4871	70	31	)	)	PUNCT
dpc-4871	70	32	.	.	PUNCT
dpc-4871	71	1	in	in	ADP
dpc-4871	71	2	particular	particular	ADJ
dpc-4871	71	3	,	,	PUNCT
dpc-4871	71	4	acitretin	acitretin	NOUN
dpc-4871	71	5	was	be	AUX
dpc-4871	71	6	favored	favor	VERB
dpc-4871	71	7	in	in	ADP
dpc-4871	71	8	both	both	DET
dpc-4871	71	9	ppp	ppp	NOUN
dpc-4871	71	10	and	and	CCONJ
dpc-4871	71	11	gpp	gpp	NOUN
dpc-4871	71	12	+	+	CCONJ
dpc-4871	71	13	pso	pso	NOUN
dpc-4871	71	14	groups	group	NOUN
dpc-4871	71	15	(	(	PUNCT
dpc-4871	71	16	21.7	21.7	NUM
dpc-4871	71	17	%	%	NOUN
dpc-4871	71	18	versus	versus	ADP
dpc-4871	71	19	35.4	35.4	NUM
dpc-4871	71	20	%	%	NOUN
dpc-4871	71	21	)	)	PUNCT
dpc-4871	71	22	followed	follow	VERB
dpc-4871	71	23	by	by	ADP
dpc-4871	71	24	cyclosporine	cyclosporine	PROPN
dpc-4871	71	25	(	(	PUNCT
dpc-4871	71	26	8.7	8.7	NUM
dpc-4871	71	27	%	%	NOUN
dpc-4871	71	28	versus	versus	ADP
dpc-4871	71	29	6.4	6.4	NUM
dpc-4871	71	30	%	%	NOUN
dpc-4871	71	31	)	)	PUNCT
dpc-4871	71	32	,	,	PUNCT
dpc-4871	71	33	methotrexate	methotrexate	NOUN
dpc-4871	71	34	(	(	PUNCT
dpc-4871	71	35	8.7	8.7	NUM
dpc-4871	71	36	%	%	NOUN
dpc-4871	71	37	versus	versus	ADP
dpc-4871	71	38	14.5	14.5	NUM
dpc-4871	71	39	%	%	NOUN
dpc-4871	71	40	)	)	PUNCT
dpc-4871	71	41	and	and	CCONJ
dpc-4871	71	42	apremilast	apremilast	VERB
dpc-4871	71	43	(	(	PUNCT
dpc-4871	71	44	4.3	4.3	NUM
dpc-4871	71	45	%	%	NOUN
dpc-4871	71	46	versus	versus	ADP
dpc-4871	71	47	3.2	3.2	NUM
dpc-4871	71	48	%	%	NOUN
dpc-4871	71	49	)	)	PUNCT
dpc-4871	71	50	.	.	PUNCT
dpc-4871	72	1	among	among	ADP
dpc-4871	72	2	the	the	DET
dpc-4871	72	3	biological	biological	ADJ
dpc-4871	72	4	therapies	therapy	NOUN
dpc-4871	72	5	,	,	PUNCT
dpc-4871	72	6	secukinumab	secukinumab	NOUN
dpc-4871	72	7	and	and	CCONJ
dpc-4871	72	8	adalimumab	adalimumab	NOUN
dpc-4871	72	9	were	be	AUX
dpc-4871	72	10	the	the	DET
dpc-4871	72	11	only	only	ADJ
dpc-4871	72	12	2	2	NUM
dpc-4871	72	13	options	option	NOUN
dpc-4871	72	14	for	for	ADP
dpc-4871	72	15	ppp	ppp	NOUN
dpc-4871	72	16	(	(	PUNCT
dpc-4871	72	17	13	13	NUM
dpc-4871	72	18	%	%	NOUN
dpc-4871	72	19	and	and	CCONJ
dpc-4871	72	20	8.7	8.7	NUM
dpc-4871	72	21	%	%	NOUN
dpc-4871	72	22	,	,	PUNCT
dpc-4871	72	23	respectively	respectively	ADV
dpc-4871	72	24	)	)	PUNCT
dpc-4871	72	25	,	,	PUNCT
dpc-4871	72	26	whereas	whereas	SCONJ
dpc-4871	72	27	adalimumab	adalimumab	NOUN
dpc-4871	72	28	(	(	PUNCT
dpc-4871	72	29	11.3	11.3	NUM
dpc-4871	72	30	%	%	NOUN
dpc-4871	72	31	)	)	PUNCT
dpc-4871	72	32	,	,	PUNCT
dpc-4871	72	33	brodalumab	brodalumab	NOUN
dpc-4871	72	34	(	(	PUNCT
dpc-4871	72	35	4.8	4.8	NUM
dpc-4871	72	36	%	%	NOUN
dpc-4871	72	37	)	)	PUNCT
dpc-4871	72	38	,	,	PUNCT
dpc-4871	72	39	ixekizumab	ixekizumab	NOUN
dpc-4871	72	40	(	(	PUNCT
dpc-4871	72	41	4.8	4.8	NUM
dpc-4871	72	42	%	%	NOUN
dpc-4871	72	43	)	)	PUNCT
dpc-4871	72	44	,	,	PUNCT
dpc-4871	72	45	certolizumab	certolizumab	NOUN
dpc-4871	72	46	(	(	PUNCT
dpc-4871	72	47	3.2	3.2	NUM
dpc-4871	72	48	%	%	NOUN
dpc-4871	72	49	)	)	PUNCT
dpc-4871	72	50	,	,	PUNCT
dpc-4871	72	51	etanercept	etanercept	NOUN
dpc-4871	72	52	(	(	PUNCT
dpc-4871	72	53	3.2	3.2	NUM
dpc-4871	72	54	%	%	NOUN
dpc-4871	72	55	)	)	PUNCT
dpc-4871	72	56	,	,	PUNCT
dpc-4871	72	57	secukinumab	secukinumab	NOUN
dpc-4871	72	58	(	(	PUNCT
dpc-4871	72	59	3.2	3.2	NUM
dpc-4871	72	60	%	%	NOUN
dpc-4871	72	61	)	)	PUNCT
dpc-4871	72	62	,	,	PUNCT
dpc-4871	72	63	tildrakizumab	tildrakizumab	NOUN
dpc-4871	72	64	(	(	PUNCT
dpc-4871	72	65	3.2	3.2	NUM
dpc-4871	72	66	%	%	NOUN
dpc-4871	72	67	)	)	PUNCT
dpc-4871	72	68	,	,	PUNCT
dpc-4871	72	69	ustekinumab	ustekinumab	NOUN
dpc-4871	72	70	(	(	PUNCT
dpc-4871	72	71	3.2	3.2	NUM
dpc-4871	72	72	%	%	NOUN
dpc-4871	72	73	)	)	PUNCT
dpc-4871	72	74	,	,	PUNCT
dpc-4871	72	75	guselkumab	guselkumab	NOUN
dpc-4871	72	76	(	(	PUNCT
dpc-4871	72	77	1.6	1.6	NUM
dpc-4871	72	78	%	%	NOUN
dpc-4871	72	79	)	)	PUNCT
dpc-4871	72	80	and	and	CCONJ
dpc-4871	72	81	risankizumab	risankizumab	NOUN
dpc-4871	72	82	(	(	PUNCT
dpc-4871	72	83	1.6	1.6	NUM
dpc-4871	72	84	%	%	NOUN
dpc-4871	72	85	)	)	PUNCT
dpc-4871	72	86	were	be	AUX
dpc-4871	72	87	the	the	DET
dpc-4871	72	88	therapeutical	therapeutical	ADJ
dpc-4871	72	89	options	option	NOUN
dpc-4871	72	90	for	for	ADP
dpc-4871	72	91	gpp	gpp	NOUN
dpc-4871	72	92	+	+	X
dpc-4871	72	93	pso	pso	NOUN
dpc-4871	72	94	.	.	PUNCT
dpc-4871	73	1	it	it	PRON
dpc-4871	73	2	is	be	AUX
dpc-4871	73	3	of	of	ADP
dpc-4871	73	4	note	note	NOUN
dpc-4871	73	5	that	that	SCONJ
dpc-4871	73	6	only	only	ADV
dpc-4871	73	7	1	1	NUM
dpc-4871	73	8	patient	patient	NOUN
dpc-4871	73	9	with	with	ADP
dpc-4871	73	10	ggp	ggp	NOUN
dpc-4871	73	11	+	+	CCONJ
dpc-4871	73	12	pso	pso	NOUN
dpc-4871	73	13	(	(	PUNCT
dpc-4871	73	14	0.9	0.9	NUM
dpc-4871	73	15	%	%	NOUN
dpc-4871	73	16	)	)	PUNCT
dpc-4871	73	17	was	be	AUX
dpc-4871	73	18	on	on	ADP
dpc-4871	73	19	concomitant	concomitant	ADJ
dpc-4871	73	20	therapy	therapy	NOUN
dpc-4871	73	21	with	with	ADP
dpc-4871	73	22	adalimumab	adalimumab	NOUN
dpc-4871	73	23	+	+	CCONJ
dpc-4871	73	24	methotrexate	methotrexate	NOUN
dpc-4871	73	25	,	,	PUNCT
dpc-4871	73	26	whereas	whereas	SCONJ
dpc-4871	73	27	the	the	DET
dpc-4871	73	28	remaining	remain	VERB
dpc-4871	73	29	ppp	ppp	NOUN
dpc-4871	73	30	patients	patient	NOUN
dpc-4871	73	31	(	(	PUNCT
dpc-4871	73	32	n	n	NOUN
dpc-4871	73	33	=	=	SYM
dpc-4871	73	34	16	16	NUM
dpc-4871	73	35	,	,	PUNCT
dpc-4871	73	36	14.8	14.8	NUM
dpc-4871	73	37	%	%	NOUN
dpc-4871	73	38	)	)	PUNCT
dpc-4871	73	39	were	be	AUX
dpc-4871	73	40	being	be	AUX
dpc-4871	73	41	treated	treat	VERB
dpc-4871	73	42	with	with	ADP
dpc-4871	73	43	topical	topical	ADJ
dpc-4871	73	44	therapy	therapy	NOUN
dpc-4871	73	45	.	.	PUNCT
dpc-4871	74	1	disease	disease	NOUN
dpc-4871	74	2	burden	burden	NOUN
dpc-4871	74	3	and	and	CCONJ
dpc-4871	74	4	quality	quality	NOUN
dpc-4871	74	5	life	life	NOUN
dpc-4871	74	6	of	of	ADP
dpc-4871	74	7	patients	patient	NOUN
dpc-4871	74	8	gpp	gpp	VERB
dpc-4871	74	9	+	+	CCONJ
dpc-4871	74	10	pso	pso	NOUN
dpc-4871	74	11	imposed	impose	VERB
dpc-4871	74	12	a	a	DET
dpc-4871	74	13	substantial	substantial	ADJ
dpc-4871	74	14	burden	burden	NOUN
dpc-4871	74	15	on	on	ADP
dpc-4871	74	16	patient	patient	ADJ
dpc-4871	74	17	qol	qol	PROPN
dpc-4871	74	18	.	.	PUNCT
dpc-4871	75	1	indeed	indeed	ADV
dpc-4871	75	2	,	,	PUNCT
dpc-4871	75	3	life	life	NOUN
dpc-4871	75	4	quality	quality	NOUN
dpc-4871	75	5	impairment	impairment	NOUN
dpc-4871	75	6	(	(	PUNCT
dpc-4871	75	7	dlqi	dlqi	PROPN
dpc-4871	75	8	≥10	≥10	VERB
dpc-4871	75	9	)	)	PUNCT
dpc-4871	75	10	was	be	AUX
dpc-4871	75	11	reported	report	VERB
dpc-4871	75	12	mostly	mostly	ADV
dpc-4871	75	13	in	in	ADP
dpc-4871	75	14	gpp	gpp	NOUN
dpc-4871	75	15	+	+	CCONJ
dpc-4871	75	16	pso	pso	NOUN
dpc-4871	75	17	patients	patient	NOUN
dpc-4871	75	18	than	than	ADP
dpc-4871	75	19	in	in	ADP
dpc-4871	75	20	ppp	ppp	NOUN
dpc-4871	75	21	(	(	PUNCT
dpc-4871	75	22	45	45	NUM
dpc-4871	75	23	%	%	NOUN
dpc-4871	75	24	versus	versus	ADP
dpc-4871	75	25	24	24	NUM
dpc-4871	75	26	%	%	NOUN
dpc-4871	75	27	,	,	PUNCT
dpc-4871	75	28	p	p	X
dpc-4871	75	29	<	<	X
dpc-4871	75	30	0.01	0.01	NUM
dpc-4871	75	31	)	)	PUNCT
dpc-4871	75	32	.	.	PUNCT
dpc-4871	76	1	however	however	ADV
dpc-4871	76	2	,	,	PUNCT
dpc-4871	76	3	no	no	DET
dpc-4871	76	4	significant	significant	ADJ
dpc-4871	76	5	difference	difference	NOUN
dpc-4871	76	6	in	in	ADP
dpc-4871	76	7	terms	term	NOUN
dpc-4871	76	8	of	of	ADP
dpc-4871	76	9	disease	disease	NOUN
dpc-4871	76	10	severity	severity	NOUN
dpc-4871	76	11	examined	examine	VERB
dpc-4871	76	12	through	through	ADP
dpc-4871	76	13	the	the	DET
dpc-4871	76	14	adapted	adapt	VERB
dpc-4871	76	15	scores	score	NOUN
dpc-4871	76	16	for	for	ADP
dpc-4871	76	17	ppp	ppp	NOUN
dpc-4871	76	18	and	and	CCONJ
dpc-4871	76	19	gpp	gpp	NOUN
dpc-4871	76	20	+	+	CCONJ
dpc-4871	76	21	pso	pso	NOUN
dpc-4871	76	22	was	be	AUX
dpc-4871	76	23	shown	show	VERB
dpc-4871	76	24	in	in	ADP
dpc-4871	76	25	both	both	DET
dpc-4871	76	26	groups	group	NOUN
dpc-4871	76	27	of	of	ADP
dpc-4871	76	28	patients	patient	NOUN
dpc-4871	76	29	.	.	PUNCT
dpc-4871	77	1	major	major	ADJ
dpc-4871	77	2	details	detail	NOUN
dpc-4871	77	3	are	be	AUX
dpc-4871	77	4	summarized	summarize	VERB
dpc-4871	77	5	in	in	ADP
dpc-4871	77	6	figure	figure	NOUN
dpc-4871	77	7	1	1	NUM
dpc-4871	77	8	.	.	PUNCT
dpc-4871	78	1	therapies	therapy	NOUN
dpc-4871	78	2	associated	associate	VERB
dpc-4871	78	3	with	with	ADP
dpc-4871	78	4	dlqi	dlqi	ADJ
dpc-4871	78	5	categories	category	NOUN
dpc-4871	78	6	(	(	PUNCT
dpc-4871	78	7	<	<	X
dpc-4871	78	8	10	10	NUM
dpc-4871	78	9	and	and	CCONJ
dpc-4871	78	10	≥10	≥10	ADJ
dpc-4871	78	11	)	)	PUNCT
dpc-4871	78	12	in	in	ADP
dpc-4871	78	13	patients	patient	NOUN
dpc-4871	78	14	with	with	ADP
dpc-4871	78	15	pustular	pustular	ADJ
dpc-4871	78	16	psoriasis	psoriasis	NOUN
dpc-4871	78	17	our	our	PRON
dpc-4871	78	18	multiple	multiple	ADJ
dpc-4871	78	19	logistic	logistic	ADJ
dpc-4871	78	20	regression	regression	NOUN
dpc-4871	78	21	analysis	analysis	NOUN
dpc-4871	78	22	revealed	reveal	VERB
dpc-4871	78	23	that	that	SCONJ
dpc-4871	78	24	gpp	gpp	NOUN
dpc-4871	78	25	+	+	CCONJ
dpc-4871	78	26	pso	pso	NOUN
dpc-4871	78	27	patients	patient	NOUN
dpc-4871	78	28	with	with	ADP
dpc-4871	78	29	a	a	DET
dpc-4871	78	30	dlqi	dlqi	ADJ
dpc-4871	78	31	score	score	NOUN
dpc-4871	78	32	<	<	X
dpc-4871	78	33	10	10	NUM
dpc-4871	78	34	had	have	VERB
dpc-4871	78	35	a	a	DET
dpc-4871	78	36	significant	significant	ADJ
dpc-4871	78	37	inverse	inverse	NOUN
dpc-4871	78	38	correlation	correlation	NOUN
dpc-4871	78	39	with	with	ADP
dpc-4871	78	40	certain	certain	ADJ
dpc-4871	78	41	biologics	biologic	NOUN
dpc-4871	78	42	,	,	PUNCT
dpc-4871	78	43	eg	eg	ADP
dpc-4871	78	44	anti	anti	NOUN
dpc-4871	78	45	-	-	NOUN
dpc-4871	78	46	tnfα	tnfα	ADJ
dpc-4871	78	47	,	,	PUNCT
dpc-4871	78	48	anti	anti	ADJ
dpc-4871	78	49	-	-	ADJ
dpc-4871	78	50	il-12/23	il-12/23	ADJ
dpc-4871	78	51	,	,	PUNCT
dpc-4871	78	52	and	and	CCONJ
dpc-4871	78	53	anti	anti	ADJ
dpc-4871	78	54	-	-	ADJ
dpc-4871	78	55	il-17	il-17	ADJ
dpc-4871	78	56	therapies	therapy	NOUN
dpc-4871	78	57	(	(	PUNCT
dpc-4871	78	58	certolizumab	certolizumab	NOUN
dpc-4871	78	59	[	[	X
dpc-4871	78	60	or	or	CCONJ
dpc-4871	78	61	0.47	0.47	NUM
dpc-4871	78	62	;	;	PUNCT
dpc-4871	78	63	95	95	NUM
dpc-4871	78	64	%	%	NOUN
dpc-4871	78	65	ci	ci	NOUN
dpc-4871	78	66	0.08	0.08	NUM
dpc-4871	78	67	-	-	SYM
dpc-4871	78	68	3.02	3.02	NUM
dpc-4871	78	69	;	;	PUNCT
dpc-4871	78	70	p	p	X
dpc-4871	78	71	=	=	NOUN
dpc-4871	78	72	0.041	0.041	NUM
dpc-4871	78	73	]	]	PUNCT
dpc-4871	78	74	,	,	PUNCT
dpc-4871	78	75	etanercept	etanercept	VERB
dpc-4871	78	76	[	[	X
dpc-4871	78	77	or	or	CCONJ
dpc-4871	78	78	0.54	0.54	NUM
dpc-4871	78	79	;	;	PUNCT
dpc-4871	78	80	table	table	NOUN
dpc-4871	78	81	1	1	NUM
dpc-4871	78	82	.	.	PUNCT
dpc-4871	78	83	clinical	clinical	ADJ
dpc-4871	78	84	and	and	CCONJ
dpc-4871	78	85	epidemiological	epidemiological	ADJ
dpc-4871	78	86	data	datum	NOUN
dpc-4871	78	87	of	of	ADP
dpc-4871	78	88	gpp	gpp	NOUN
dpc-4871	78	89	+	+	CCONJ
dpc-4871	78	90	pso	pso	NOUN
dpc-4871	78	91	and	and	CCONJ
dpc-4871	78	92	ppp	ppp	NOUN
dpc-4871	78	93	gpp	gpp	NOUN
dpc-4871	78	94	+	+	CCONJ
dpc-4871	78	95	pso	pso	NOUN
dpc-4871	78	96	n=62	n=62	CCONJ
dpc-4871	78	97	ppp	ppp	PROPN
dpc-4871	78	98	n=46	n=46	PROPN
dpc-4871	78	99	population	population	NOUN
dpc-4871	78	100	female	female	NOUN
dpc-4871	78	101	44	44	NUM
dpc-4871	78	102	(	(	PUNCT
dpc-4871	78	103	71	71	NUM
dpc-4871	78	104	%	%	NOUN
dpc-4871	78	105	)	)	PUNCT
dpc-4871	78	106	20	20	NUM
dpc-4871	78	107	(	(	PUNCT
dpc-4871	78	108	43	43	NUM
dpc-4871	78	109	%	%	NOUN
dpc-4871	78	110	)	)	PUNCT
dpc-4871	78	111	male	male	NOUN
dpc-4871	78	112	18	18	NUM
dpc-4871	78	113	(	(	PUNCT
dpc-4871	78	114	29	29	NUM
dpc-4871	78	115	%	%	NOUN
dpc-4871	78	116	)	)	PUNCT
dpc-4871	78	117	26	26	NUM
dpc-4871	78	118	(	(	PUNCT
dpc-4871	78	119	57	57	NUM
dpc-4871	78	120	%	%	NOUN
dpc-4871	78	121	)	)	PUNCT
dpc-4871	78	122	mean	mean	NOUN
dpc-4871	78	123	age	age	NOUN
dpc-4871	78	124	,	,	PUNCT
dpc-4871	78	125	years	year	NOUN
dpc-4871	78	126	±	±	NUM
dpc-4871	78	127	sd	sd	ADP
dpc-4871	78	128	62.9	62.9	NUM
dpc-4871	78	129	±	±	NUM
dpc-4871	78	130	5,7	5,7	NUM
dpc-4871	78	131	60.8	60.8	NUM
dpc-4871	78	132	±	±	NUM
dpc-4871	78	133	6,4	6,4	NUM
dpc-4871	78	134	mean	mean	NOUN
dpc-4871	78	135	age	age	NOUN
dpc-4871	78	136	onset	onset	NOUN
dpc-4871	78	137	disease	disease	NOUN
dpc-4871	78	138	51.2	51.2	NUM
dpc-4871	78	139	±	±	NUM
dpc-4871	78	140	4,8	4,8	NUM
dpc-4871	78	141	48,8	48,8	NUM
dpc-4871	78	142	±	±	NOUN
dpc-4871	78	143	3,5	3,5	NUM
dpc-4871	78	144	mean	mean	NOUN
dpc-4871	78	145	bmi	bmi	PROPN
dpc-4871	78	146	±	±	PROPN
dpc-4871	78	147	sd	sd	ADP
dpc-4871	78	148	26.3	26.3	NUM
dpc-4871	78	149	±	±	NUM
dpc-4871	78	150	4,1	4,1	NUM
dpc-4871	78	151	24.1	24.1	NUM
dpc-4871	78	152	±	±	NUM
dpc-4871	78	153	3,6	3,6	NUM
dpc-4871	78	154	dlqi	dlqi	NOUN
dpc-4871	78	155	<	<	X
dpc-4871	78	156	10	10	NUM
dpc-4871	78	157	34	34	NUM
dpc-4871	78	158	(	(	PUNCT
dpc-4871	78	159	55	55	NUM
dpc-4871	78	160	%	%	NOUN
dpc-4871	78	161	)	)	PUNCT
dpc-4871	78	162	35	35	NUM
dpc-4871	78	163	(	(	PUNCT
dpc-4871	78	164	76	76	NUM
dpc-4871	78	165	%	%	NOUN
dpc-4871	78	166	)	)	PUNCT
dpc-4871	79	1	dlqi	dlqi	PROPN
dpc-4871	79	2	≥10	≥10	PROPN
dpc-4871	79	3	28	28	NUM
dpc-4871	79	4	(	(	PUNCT
dpc-4871	79	5	45	45	NUM
dpc-4871	79	6	%	%	NOUN
dpc-4871	79	7	)	)	PUNCT
dpc-4871	79	8	11	11	NUM
dpc-4871	79	9	(	(	PUNCT
dpc-4871	79	10	24	24	NUM
dpc-4871	79	11	%	%	NOUN
dpc-4871	79	12	)	)	PUNCT
dpc-4871	79	13	comorbidities	comorbiditie	NOUN
dpc-4871	79	14	hypertension	hypertension	NOUN
dpc-4871	79	15	43	43	NUM
dpc-4871	79	16	(	(	PUNCT
dpc-4871	79	17	69	69	NUM
dpc-4871	79	18	%	%	NOUN
dpc-4871	79	19	)	)	PUNCT
dpc-4871	79	20	21	21	NUM
dpc-4871	79	21	(	(	PUNCT
dpc-4871	79	22	45	45	NUM
dpc-4871	79	23	%	%	NOUN
dpc-4871	79	24	)	)	PUNCT
dpc-4871	79	25	dyslipidemia	dyslipidemia	VERB
dpc-4871	79	26	11	11	NUM
dpc-4871	79	27	(	(	PUNCT
dpc-4871	79	28	18	18	NUM
dpc-4871	79	29	%	%	NOUN
dpc-4871	79	30	)	)	PUNCT
dpc-4871	79	31	6	6	NUM
dpc-4871	79	32	(	(	PUNCT
dpc-4871	79	33	13	13	NUM
dpc-4871	79	34	%	%	NOUN
dpc-4871	79	35	)	)	PUNCT
dpc-4871	79	36	psoriatic	psoriatic	ADJ
dpc-4871	79	37	arthritis	arthritis	NOUN
dpc-4871	79	38	10	10	NUM
dpc-4871	79	39	(	(	PUNCT
dpc-4871	79	40	16	16	NUM
dpc-4871	79	41	%	%	NOUN
dpc-4871	79	42	)	)	PUNCT
dpc-4871	79	43	5	5	NUM
dpc-4871	79	44	(	(	PUNCT
dpc-4871	79	45	11	11	NUM
dpc-4871	79	46	%	%	NOUN
dpc-4871	79	47	)	)	PUNCT
dpc-4871	79	48	cardiomyopathy	cardiomyopathy	ADJ
dpc-4871	79	49	9	9	NUM
dpc-4871	79	50	(	(	PUNCT
dpc-4871	79	51	14	14	NUM
dpc-4871	79	52	%	%	NOUN
dpc-4871	79	53	)	)	PUNCT
dpc-4871	79	54	2	2	NUM
dpc-4871	79	55	(	(	PUNCT
dpc-4871	79	56	4	4	NUM
dpc-4871	79	57	%	%	NOUN
dpc-4871	79	58	)	)	PUNCT
dpc-4871	79	59	diabetes	diabetes	NOUN
dpc-4871	79	60	mellitus	mellitus	NOUN
dpc-4871	79	61	6	6	NUM
dpc-4871	79	62	(	(	PUNCT
dpc-4871	79	63	10	10	NUM
dpc-4871	79	64	%	%	NOUN
dpc-4871	79	65	)	)	PUNCT
dpc-4871	79	66	2	2	NUM
dpc-4871	79	67	(	(	PUNCT
dpc-4871	79	68	4	4	NUM
dpc-4871	79	69	%	%	NOUN
dpc-4871	79	70	)	)	PUNCT
dpc-4871	79	71	hypothyroidism	hypothyroidism	NOUN
dpc-4871	79	72	3	3	NUM
dpc-4871	79	73	(	(	PUNCT
dpc-4871	79	74	5	5	NUM
dpc-4871	79	75	%	%	NOUN
dpc-4871	79	76	)	)	PUNCT
dpc-4871	79	77	1	1	NUM
dpc-4871	79	78	(	(	PUNCT
dpc-4871	79	79	2	2	NUM
dpc-4871	79	80	%	%	NOUN
dpc-4871	79	81	)	)	PUNCT
dpc-4871	79	82	ulcerative	ulcerative	ADJ
dpc-4871	79	83	colitis	colitis	NOUN
dpc-4871	79	84	2	2	NUM
dpc-4871	79	85	(	(	PUNCT
dpc-4871	79	86	3	3	NUM
dpc-4871	79	87	%	%	NOUN
dpc-4871	79	88	)	)	PUNCT
dpc-4871	79	89	1	1	NUM
dpc-4871	79	90	(	(	PUNCT
dpc-4871	79	91	2	2	NUM
dpc-4871	79	92	%	%	NOUN
dpc-4871	79	93	)	)	PUNCT
dpc-4871	79	94	previous	previous	ADJ
dpc-4871	79	95	therapies	therapy	NOUN
dpc-4871	79	96	systemic	systemic	ADJ
dpc-4871	79	97	nonbiological	nonbiological	ADJ
dpc-4871	79	98	48	48	NUM
dpc-4871	79	99	(	(	PUNCT
dpc-4871	79	100	77	77	NUM
dpc-4871	79	101	%	%	NOUN
dpc-4871	79	102	)	)	PUNCT
dpc-4871	79	103	24	24	NUM
dpc-4871	79	104	(	(	PUNCT
dpc-4871	79	105	52	52	NUM
dpc-4871	79	106	%	%	NOUN
dpc-4871	79	107	)	)	PUNCT
dpc-4871	79	108	systemic	systemic	ADJ
dpc-4871	79	109	biological	biological	ADJ
dpc-4871	79	110	10	10	NUM
dpc-4871	79	111	(	(	PUNCT
dpc-4871	79	112	16	16	NUM
dpc-4871	79	113	%	%	NOUN
dpc-4871	79	114	)	)	PUNCT
dpc-4871	79	115	4	4	NUM
dpc-4871	79	116	(	(	PUNCT
dpc-4871	79	117	9	9	NUM
dpc-4871	79	118	%	%	NOUN
dpc-4871	79	119	)	)	PUNCT
dpc-4871	79	120	phototherapy	phototherapy	NOUN
dpc-4871	79	121	7	7	NUM
dpc-4871	79	122	(	(	PUNCT
dpc-4871	79	123	11	11	NUM
dpc-4871	79	124	%	%	NOUN
dpc-4871	79	125	)	)	PUNCT
dpc-4871	79	126	3	3	NUM
dpc-4871	79	127	(	(	PUNCT
dpc-4871	79	128	6	6	NUM
dpc-4871	79	129	%	%	NOUN
dpc-4871	79	130	)	)	PUNCT
dpc-4871	79	131	topical	topical	ADJ
dpc-4871	79	132	therapy	therapy	NOUN
dpc-4871	79	133	8	8	NUM
dpc-4871	79	134	(	(	PUNCT
dpc-4871	79	135	13	13	NUM
dpc-4871	79	136	%	%	NOUN
dpc-4871	79	137	)	)	PUNCT
dpc-4871	79	138	4	4	NUM
dpc-4871	79	139	(	(	PUNCT
dpc-4871	79	140	9	9	NUM
dpc-4871	79	141	%	%	NOUN
dpc-4871	79	142	)	)	PUNCT
dpc-4871	79	143	current	current	ADJ
dpc-4871	79	144	therapies	therapy	NOUN
dpc-4871	79	145	systemic	systemic	ADJ
dpc-4871	79	146	nonbiological	nonbiological	ADJ
dpc-4871	79	147	37	37	NUM
dpc-4871	79	148	(	(	PUNCT
dpc-4871	79	149	60	60	NUM
dpc-4871	79	150	%	%	NOUN
dpc-4871	79	151	)	)	PUNCT
dpc-4871	79	152	20	20	NUM
dpc-4871	79	153	(	(	PUNCT
dpc-4871	79	154	43	43	NUM
dpc-4871	79	155	%	%	NOUN
dpc-4871	79	156	)	)	PUNCT
dpc-4871	79	157	systemic	systemic	ADJ
dpc-4871	79	158	biological	biological	ADJ
dpc-4871	79	159	25	25	NUM
dpc-4871	79	160	(	(	PUNCT
dpc-4871	79	161	40	40	NUM
dpc-4871	79	162	%	%	NOUN
dpc-4871	79	163	)	)	PUNCT
dpc-4871	79	164	10	10	NUM
dpc-4871	79	165	(	(	PUNCT
dpc-4871	79	166	22	22	NUM
dpc-4871	79	167	%	%	NOUN
dpc-4871	79	168	)	)	PUNCT
dpc-4871	79	169	topical	topical	ADJ
dpc-4871	79	170	therapy	therapy	NOUN
dpc-4871	79	171	0	0	PUNCT
dpc-4871	80	1	(	(	PUNCT
dpc-4871	80	2	0	0	NUM
dpc-4871	80	3	%	%	NOUN
dpc-4871	80	4	)	)	PUNCT
dpc-4871	80	5	16	16	NUM
dpc-4871	80	6	(	(	PUNCT
dpc-4871	80	7	35	35	NUM
dpc-4871	80	8	%	%	NOUN
dpc-4871	80	9	)	)	PUNCT
dpc-4871	80	10	bmi	bmi	PROPN
dpc-4871	80	11	:	:	PUNCT
dpc-4871	80	12	body	body	NOUN
dpc-4871	80	13	mass	mass	PROPN
dpc-4871	80	14	index	index	NOUN
dpc-4871	80	15	;	;	PUNCT
dpc-4871	80	16	dlqi	dlqi	ADJ
dpc-4871	80	17	:	:	PUNCT
dpc-4871	80	18	dermatology	dermatology	NOUN
dpc-4871	80	19	life	life	NOUN
dpc-4871	80	20	quality	quality	NOUN
dpc-4871	80	21	index	index	NOUN
dpc-4871	80	22	;	;	PUNCT
dpc-4871	80	23	gpp	gpp	NOUN
dpc-4871	80	24	+	+	X
dpc-4871	80	25	pso	pso	NOUN
dpc-4871	80	26	:	:	PUNCT
dpc-4871	80	27	plaque	plaque	NOUN
dpc-4871	80	28	psoriasis	psoriasis	NOUN
dpc-4871	80	29	associated	associate	VERB
dpc-4871	80	30	with	with	ADP
dpc-4871	80	31	generalized	generalized	ADJ
dpc-4871	80	32	pustular	pustular	ADJ
dpc-4871	80	33	forms	form	NOUN
dpc-4871	80	34	of	of	ADP
dpc-4871	80	35	psoriasis	psoriasis	NOUN
dpc-4871	80	36	;	;	PUNCT
dpc-4871	80	37	sd	sd	X
dpc-4871	80	38	:	:	PUNCT
dpc-4871	80	39	standard	standard	ADJ
dpc-4871	80	40	deviation	deviation	NOUN
dpc-4871	80	41	.	.	PUNCT
dpc-4871	81	1	4	4	NUM
dpc-4871	81	2	original	original	ADJ
dpc-4871	81	3	article	article	NOUN
dpc-4871	81	4	|	|	ADV
dpc-4871	81	5	dermatol	dermatol	ADJ
dpc-4871	81	6	pract	pract	NOUN
dpc-4871	81	7	concept	concept	NOUN
dpc-4871	81	8	.	.	PUNCT
dpc-4871	82	1	2025;15(1):4871	2025;15(1):4871	PROPN
dpc-4871	82	2	figure	figure	NOUN
dpc-4871	82	3	1	1	NUM
dpc-4871	82	4	.	.	PUNCT
dpc-4871	83	1	comparison	comparison	NOUN
dpc-4871	83	2	of	of	ADP
dpc-4871	83	3	gravity	gravity	NOUN
dpc-4871	83	4	indexes	index	NOUN
dpc-4871	83	5	score	score	NOUN
dpc-4871	83	6	between	between	ADP
dpc-4871	83	7	ppp	ppp	NOUN
dpc-4871	83	8	(	(	PUNCT
dpc-4871	83	9	n	n	NOUN
dpc-4871	83	10	=	=	SYM
dpc-4871	83	11	46	46	NUM
dpc-4871	83	12	,	,	PUNCT
dpc-4871	83	13	orange	orange	NOUN
dpc-4871	83	14	bar	bar	PROPN
dpc-4871	83	15	)	)	PUNCT
dpc-4871	83	16	and	and	CCONJ
dpc-4871	83	17	gpp	gpp	NOUN
dpc-4871	83	18	+	+	CCONJ
dpc-4871	83	19	pso	pso	NOUN
dpc-4871	83	20	(	(	PUNCT
dpc-4871	83	21	n	n	NOUN
dpc-4871	83	22	=	=	SYM
dpc-4871	83	23	62	62	NUM
dpc-4871	83	24	,	,	PUNCT
dpc-4871	83	25	yellow	yellow	ADJ
dpc-4871	83	26	bar	bar	NOUN
dpc-4871	83	27	)	)	PUNCT
dpc-4871	83	28	.	.	PUNCT
dpc-4871	84	1	dlqi	dlqi	VERB
dpc-4871	84	2	=	=	PUNCT
dpc-4871	84	3	dermatology	dermatology	NOUN
dpc-4871	84	4	life	life	NOUN
dpc-4871	84	5	quality	quality	NOUN
dpc-4871	84	6	index	index	NOUN
dpc-4871	84	7	;	;	PUNCT
dpc-4871	84	8	gpp	gpp	NOUN
dpc-4871	84	9	=	=	SYM
dpc-4871	84	10	generalized	generalize	VERB
dpc-4871	84	11	pustular	pustular	ADJ
dpc-4871	84	12	psoriasis	psoriasis	NOUN
dpc-4871	84	13	;	;	PUNCT
dpc-4871	85	1	pso	pso	NOUN
dpc-4871	85	2	=	=	NOUN
dpc-4871	85	3	psoriasis	psoriasis	NOUN
dpc-4871	85	4	.	.	PUNCT
dpc-4871	86	1	table	table	NOUN
dpc-4871	86	2	2	2	NUM
dpc-4871	86	3	.	.	PUNCT
dpc-4871	87	1	comparison	comparison	NOUN
dpc-4871	87	2	of	of	ADP
dpc-4871	87	3	current	current	ADJ
dpc-4871	87	4	systemic	systemic	ADJ
dpc-4871	87	5	therapies	therapy	NOUN
dpc-4871	87	6	in	in	ADP
dpc-4871	87	7	ppp	ppp	PROPN
dpc-4871	87	8	(	(	PUNCT
dpc-4871	87	9	n	n	NOUN
dpc-4871	87	10	=	=	SYM
dpc-4871	87	11	46	46	NUM
dpc-4871	87	12	)	)	PUNCT
dpc-4871	87	13	and	and	CCONJ
dpc-4871	87	14	gpp	gpp	NOUN
dpc-4871	87	15	+	+	CCONJ
dpc-4871	87	16	pso	pso	NOUN
dpc-4871	87	17	(	(	PUNCT
dpc-4871	87	18	n	n	NOUN
dpc-4871	87	19	=	=	SYM
dpc-4871	87	20	62	62	NUM
dpc-4871	87	21	)	)	PUNCT
dpc-4871	87	22	.	.	PUNCT
dpc-4871	88	1	current	current	ADJ
dpc-4871	88	2	therapy	therapy	NOUN
dpc-4871	88	3	ppp	ppp	NOUN
dpc-4871	88	4	,	,	PUNCT
dpc-4871	88	5	n	n	PROPN
dpc-4871	88	6	(	(	PUNCT
dpc-4871	88	7	%	%	INTJ
dpc-4871	88	8	)	)	PUNCT
dpc-4871	88	9	gpp	gpp	NOUN
dpc-4871	88	10	+	+	X
dpc-4871	88	11	pso	pso	NOUN
dpc-4871	88	12	,	,	PUNCT
dpc-4871	88	13	n	n	CCONJ
dpc-4871	88	14	(	(	PUNCT
dpc-4871	88	15	%	%	INTJ
dpc-4871	88	16	)	)	PUNCT
dpc-4871	88	17	p	p	NOUN
dpc-4871	88	18	value	value	NOUN
dpc-4871	88	19	sign	sign	NOUN
dpc-4871	88	20	systemic	systemic	ADJ
dpc-4871	88	21	non	non	ADJ
dpc-4871	88	22	-	-	ADJ
dpc-4871	88	23	biological	biological	ADJ
dpc-4871	88	24	therapy	therapy	NOUN
dpc-4871	88	25	20	20	NUM
dpc-4871	88	26	(	(	PUNCT
dpc-4871	88	27	43	43	NUM
dpc-4871	88	28	)	)	PUNCT
dpc-4871	88	29	37	37	NUM
dpc-4871	88	30	(	(	PUNCT
dpc-4871	88	31	60	60	NUM
dpc-4871	88	32	)	)	PUNCT
dpc-4871	88	33	•	•	NOUN
dpc-4871	88	34	acitretin	acitretin	NOUN
dpc-4871	88	35	10	10	NUM
dpc-4871	88	36	(	(	PUNCT
dpc-4871	88	37	21.7	21.7	NUM
dpc-4871	88	38	)	)	PUNCT
dpc-4871	88	39	22	22	NUM
dpc-4871	88	40	(	(	PUNCT
dpc-4871	88	41	35.4	35.4	NUM
dpc-4871	88	42	)	)	PUNCT
dpc-4871	88	43	0.011	0.011	NUM
dpc-4871	88	44	•	•	NOUN
dpc-4871	88	45	cyclosporine	cyclosporine	NOUN
dpc-4871	88	46	4	4	NUM
dpc-4871	88	47	(	(	PUNCT
dpc-4871	88	48	8.7	8.7	NUM
dpc-4871	88	49	)	)	PUNCT
dpc-4871	88	50	4	4	NUM
dpc-4871	88	51	(	(	PUNCT
dpc-4871	88	52	6.4	6.4	NUM
dpc-4871	88	53	)	)	PUNCT
dpc-4871	88	54	ns	ns	NUM
dpc-4871	88	55	•	•	NOUN
dpc-4871	88	56	methotrexate	methotrexate	NOUN
dpc-4871	88	57	4	4	NUM
dpc-4871	88	58	(	(	PUNCT
dpc-4871	88	59	8.7	8.7	NUM
dpc-4871	88	60	)	)	PUNCT
dpc-4871	88	61	9	9	NUM
dpc-4871	88	62	(	(	PUNCT
dpc-4871	88	63	14.5	14.5	NUM
dpc-4871	88	64	)	)	PUNCT
dpc-4871	88	65	0.036	0.036	NUM
dpc-4871	88	66	•	•	NUM
dpc-4871	88	67	apremilast	apremilast	NOUN
dpc-4871	88	68	2	2	NUM
dpc-4871	88	69	(	(	PUNCT
dpc-4871	88	70	4.3	4.3	NUM
dpc-4871	88	71	)	)	SYM
dpc-4871	88	72	2	2	NUM
dpc-4871	88	73	(	(	PUNCT
dpc-4871	88	74	3.2	3.2	NUM
dpc-4871	88	75	)	)	PUNCT
dpc-4871	88	76	ns	ns	NUM
dpc-4871	88	77	systemic	systemic	ADJ
dpc-4871	88	78	biological	biological	ADJ
dpc-4871	88	79	therapy	therapy	NOUN
dpc-4871	88	80	10	10	NUM
dpc-4871	88	81	(	(	PUNCT
dpc-4871	88	82	22	22	NUM
dpc-4871	88	83	)	)	PUNCT
dpc-4871	88	84	25	25	NUM
dpc-4871	88	85	(	(	PUNCT
dpc-4871	88	86	40	40	NUM
dpc-4871	88	87	)	)	PUNCT
dpc-4871	88	88	•	•	NUM
dpc-4871	88	89	adalimumab	adalimumab	NOUN
dpc-4871	88	90	4	4	NUM
dpc-4871	88	91	(	(	PUNCT
dpc-4871	88	92	8.7	8.7	NUM
dpc-4871	88	93	)	)	PUNCT
dpc-4871	88	94	7	7	NUM
dpc-4871	88	95	(	(	PUNCT
dpc-4871	88	96	11.3	11.3	NUM
dpc-4871	88	97	)	)	PUNCT
dpc-4871	88	98	0.048	0.048	NUM
dpc-4871	88	99	•	•	NUM
dpc-4871	88	100	brodalumab	brodalumab	NOUN
dpc-4871	88	101	0	0	NUM
dpc-4871	88	102	(	(	PUNCT
dpc-4871	88	103	0	0	NUM
dpc-4871	88	104	)	)	PUNCT
dpc-4871	88	105	3	3	NUM
dpc-4871	88	106	(	(	PUNCT
dpc-4871	88	107	4.8	4.8	NUM
dpc-4871	88	108	)	)	PUNCT
dpc-4871	88	109	ns	ns	NUM
dpc-4871	88	110	•	•	NOUN
dpc-4871	88	111	certolizumab	certolizumab	NOUN
dpc-4871	88	112	0	0	NUM
dpc-4871	89	1	(	(	PUNCT
dpc-4871	89	2	0	0	NUM
dpc-4871	89	3	)	)	SYM
dpc-4871	89	4	2	2	NUM
dpc-4871	89	5	(	(	PUNCT
dpc-4871	89	6	3.2	3.2	NUM
dpc-4871	89	7	)	)	PUNCT
dpc-4871	89	8	ns	ns	NUM
dpc-4871	89	9	•	•	NOUN
dpc-4871	89	10	etanercept	etanercept	NOUN
dpc-4871	89	11	0	0	NUM
dpc-4871	90	1	(	(	PUNCT
dpc-4871	90	2	0	0	NUM
dpc-4871	90	3	)	)	SYM
dpc-4871	90	4	2	2	NUM
dpc-4871	90	5	(	(	PUNCT
dpc-4871	90	6	3.2	3.2	NUM
dpc-4871	90	7	)	)	PUNCT
dpc-4871	90	8	ns	ns	NUM
dpc-4871	90	9	•	•	NOUN
dpc-4871	90	10	guselkumab	guselkumab	NOUN
dpc-4871	90	11	0	0	NUM
dpc-4871	91	1	(	(	PUNCT
dpc-4871	91	2	0	0	NUM
dpc-4871	91	3	)	)	SYM
dpc-4871	91	4	1	1	NUM
dpc-4871	91	5	(	(	PUNCT
dpc-4871	91	6	1.6	1.6	NUM
dpc-4871	91	7	)	)	PUNCT
dpc-4871	91	8	ns	ns	NUM
dpc-4871	91	9	•	•	NOUN
dpc-4871	91	10	ixekizumab	ixekizumab	NOUN
dpc-4871	91	11	0	0	NUM
dpc-4871	92	1	(	(	PUNCT
dpc-4871	92	2	0	0	NUM
dpc-4871	92	3	)	)	PUNCT
dpc-4871	92	4	3	3	NUM
dpc-4871	92	5	(	(	PUNCT
dpc-4871	92	6	4.8	4.8	NUM
dpc-4871	92	7	)	)	PUNCT
dpc-4871	92	8	0.014	0.014	NUM
dpc-4871	92	9	•	•	NUM
dpc-4871	92	10	risankizumab	risankizumab	NOUN
dpc-4871	92	11	0	0	NUM
dpc-4871	92	12	(	(	PUNCT
dpc-4871	92	13	0	0	NUM
dpc-4871	92	14	)	)	SYM
dpc-4871	92	15	1	1	NUM
dpc-4871	92	16	(	(	PUNCT
dpc-4871	92	17	1.6	1.6	NUM
dpc-4871	92	18	)	)	PUNCT
dpc-4871	92	19	ns	ns	NUM
dpc-4871	92	20	•	•	NUM
dpc-4871	92	21	secukinumab	secukinumab	NOUN
dpc-4871	92	22	6	6	NUM
dpc-4871	92	23	(	(	PUNCT
dpc-4871	92	24	13	13	NUM
dpc-4871	92	25	)	)	SYM
dpc-4871	92	26	2	2	NUM
dpc-4871	92	27	(	(	PUNCT
dpc-4871	92	28	3.2	3.2	NUM
dpc-4871	92	29	)	)	PUNCT
dpc-4871	92	30	0.009	0.009	NUM
dpc-4871	92	31	•	•	NOUN
dpc-4871	92	32	tildrakizumab	tildrakizumab	NOUN
dpc-4871	92	33	0	0	NUM
dpc-4871	92	34	(	(	PUNCT
dpc-4871	92	35	0	0	NUM
dpc-4871	92	36	)	)	SYM
dpc-4871	92	37	2	2	NUM
dpc-4871	92	38	(	(	PUNCT
dpc-4871	92	39	3.2	3.2	NUM
dpc-4871	92	40	)	)	PUNCT
dpc-4871	92	41	ns	ns	NUM
dpc-4871	92	42	•	•	NOUN
dpc-4871	92	43	ustekinumab	ustekinumab	NOUN
dpc-4871	92	44	0	0	PUNCT
dpc-4871	92	45	(	(	PUNCT
dpc-4871	92	46	0	0	NUM
dpc-4871	92	47	)	)	SYM
dpc-4871	92	48	2	2	NUM
dpc-4871	92	49	(	(	PUNCT
dpc-4871	92	50	3.2	3.2	NUM
dpc-4871	92	51	)	)	PUNCT
dpc-4871	92	52	ns	ns	NUM
dpc-4871	92	53	gpp	gpp	NOUN
dpc-4871	92	54	+	+	X
dpc-4871	92	55	pso	pso	NOUN
dpc-4871	92	56	:	:	PUNCT
dpc-4871	92	57	plaque	plaque	NOUN
dpc-4871	92	58	psoriasis	psoriasis	NOUN
dpc-4871	92	59	associated	associate	VERB
dpc-4871	92	60	with	with	ADP
dpc-4871	92	61	generalized	generalized	ADJ
dpc-4871	92	62	pustular	pustular	ADJ
dpc-4871	92	63	forms	form	NOUN
dpc-4871	92	64	of	of	ADP
dpc-4871	92	65	psoriasis	psoriasis	NOUN
dpc-4871	92	66	;	;	PUNCT
dpc-4871	92	67	ns	ns	NUM
dpc-4871	92	68	:	:	PUNCT
dpc-4871	92	69	not	not	PART
dpc-4871	92	70	significant	significant	ADJ
dpc-4871	92	71	;	;	PUNCT
dpc-4871	92	72	ppp	ppp	NOUN
dpc-4871	92	73	:	:	PUNCT
dpc-4871	92	74	palmoplantar	palmoplantar	NOUN
dpc-4871	92	75	pustulosis	pustulosis	NOUN
dpc-4871	92	76	.	.	PUNCT
dpc-4871	93	1	95	95	NUM
dpc-4871	93	2	%	%	NOUN
dpc-4871	93	3	ci	ci	NOUN
dpc-4871	93	4	0.067	0.067	NUM
dpc-4871	93	5	-	-	PUNCT
dpc-4871	93	6	4.01	4.01	NUM
dpc-4871	93	7	;	;	PUNCT
dpc-4871	93	8	p	p	X
dpc-4871	93	9	=	=	PROPN
dpc-4871	93	10	0.029	0.029	NUM
dpc-4871	93	11	]	]	PUNCT
dpc-4871	93	12	,	,	PUNCT
dpc-4871	93	13	secukinumab	secukinumab	NOUN
dpc-4871	94	1	[	[	X
dpc-4871	94	2	or	or	CCONJ
dpc-4871	94	3	0.38	0.38	NUM
dpc-4871	94	4	;	;	PUNCT
dpc-4871	94	5	95	95	NUM
dpc-4871	94	6	%	%	NOUN
dpc-4871	94	7	ci	ci	NOUN
dpc-4871	94	8	0.02	0.02	NUM
dpc-4871	94	9	-	-	SYM
dpc-4871	94	10	5.01	5.01	NUM
dpc-4871	94	11	;	;	PUNCT
dpc-4871	94	12	p	p	X
dpc-4871	94	13	=	=	NOUN
dpc-4871	94	14	0.037	0.037	NUM
dpc-4871	94	15	]	]	PUNCT
dpc-4871	94	16	,	,	PUNCT
dpc-4871	94	17	and	and	CCONJ
dpc-4871	94	18	ustekinumab	ustekinumab	NOUN
dpc-4871	94	19	[	[	X
dpc-4871	94	20	or	or	CCONJ
dpc-4871	94	21	0.29	0.29	NUM
dpc-4871	94	22	;	;	PUNCT
dpc-4871	94	23	95	95	NUM
dpc-4871	94	24	%	%	NOUN
dpc-4871	94	25	ci	ci	NOUN
dpc-4871	94	26	0.01	0.01	NUM
dpc-4871	94	27	-	-	SYM
dpc-4871	94	28	4.02	4.02	NUM
dpc-4871	94	29	;	;	PUNCT
dpc-4871	94	30	p	p	X
dpc-4871	94	31	=	=	NOUN
dpc-4871	94	32	0.035	0.035	NUM
dpc-4871	94	33	]	]	PUNCT
dpc-4871	94	34	)	)	PUNCT
dpc-4871	94	35	.	.	PUNCT
dpc-4871	95	1	indeed	indeed	ADV
dpc-4871	95	2	,	,	PUNCT
dpc-4871	95	3	all	all	DET
dpc-4871	95	4	these	these	DET
dpc-4871	95	5	biological	biological	ADJ
dpc-4871	95	6	treatments	treatment	NOUN
dpc-4871	95	7	were	be	AUX
dpc-4871	95	8	positively	positively	ADV
dpc-4871	95	9	associated	associate	VERB
dpc-4871	95	10	with	with	ADP
dpc-4871	95	11	dlqi	dlqi	PROPN
dpc-4871	95	12	≥	≥	NUM
dpc-4871	95	13	10	10	NUM
dpc-4871	95	14	(	(	PUNCT
dpc-4871	95	15	certolizumab	certolizumab	NOUN
dpc-4871	95	16	[	[	X
dpc-4871	95	17	or	or	CCONJ
dpc-4871	95	18	2.38	2.38	NUM
dpc-4871	95	19	,	,	PUNCT
dpc-4871	95	20	95%-ci	95%-ci	NUM
dpc-4871	95	21	0.67	0.67	NUM
dpc-4871	95	22	-	-	SYM
dpc-4871	95	23	6.85	6.85	NUM
dpc-4871	95	24	,	,	PUNCT
dpc-4871	95	25	p	p	X
dpc-4871	95	26	=	=	NOUN
dpc-4871	95	27	0.025	0.025	NUM
dpc-4871	95	28	]	]	PUNCT
dpc-4871	95	29	,	,	PUNCT
dpc-4871	95	30	etanercept	etanercept	VERB
dpc-4871	95	31	[	[	X
dpc-4871	95	32	or	or	CCONJ
dpc-4871	95	33	2.25	2.25	NUM
dpc-4871	95	34	,	,	PUNCT
dpc-4871	95	35	95%-ci	95%-ci	NUM
dpc-4871	95	36	0.33	0.33	NUM
dpc-4871	95	37	-	-	SYM
dpc-4871	95	38	4.78	4.78	NUM
dpc-4871	95	39	,	,	PUNCT
dpc-4871	95	40	p	p	X
dpc-4871	95	41	=	=	NOUN
dpc-4871	95	42	0.041	0.041	NUM
dpc-4871	95	43	]	]	PUNCT
dpc-4871	95	44	,	,	PUNCT
dpc-4871	95	45	secukinumab	secukinumab	NOUN
dpc-4871	96	1	[	[	X
dpc-4871	96	2	or	or	CCONJ
dpc-4871	96	3	2.03	2.03	NUM
dpc-4871	96	4	,	,	PUNCT
dpc-4871	96	5	95%-ci	95%-ci	NUM
dpc-4871	96	6	0.07	0.07	NUM
dpc-4871	96	7	-	-	SYM
dpc-4871	96	8	6.55	6.55	NUM
dpc-4871	96	9	,	,	PUNCT
dpc-4871	96	10	p	p	X
dpc-4871	96	11	=	=	NOUN
dpc-4871	96	12	0.034	0.034	NUM
dpc-4871	96	13	]	]	PUNCT
dpc-4871	96	14	,	,	PUNCT
dpc-4871	96	15	or	or	CCONJ
dpc-4871	96	16	ustekinumab	ustekinumab	NOUN
dpc-4871	96	17	[	[	X
dpc-4871	96	18	or	or	CCONJ
dpc-4871	96	19	2.79	2.79	NUM
dpc-4871	96	20	,	,	PUNCT
dpc-4871	96	21	95%-ci	95%-ci	NUM
dpc-4871	96	22	0.54	0.54	NUM
dpc-4871	96	23	-	-	SYM
dpc-4871	96	24	5.68	5.68	NUM
dpc-4871	96	25	;	;	PUNCT
dpc-4871	96	26	p	p	X
dpc-4871	96	27	=	=	NOUN
dpc-4871	96	28	0.013	0.013	NUM
dpc-4871	96	29	]	]	PUNCT
dpc-4871	96	30	)	)	PUNCT
dpc-4871	96	31	.	.	PUNCT
dpc-4871	97	1	a	a	DET
dpc-4871	97	2	significant	significant	ADJ
dpc-4871	97	3	inverse	inverse	NOUN
dpc-4871	97	4	correlation	correlation	NOUN
dpc-4871	97	5	with	with	ADP
dpc-4871	97	6	dlqi	dlqi	PROPN
dpc-4871	97	7	≥	≥	PROPN
dpc-4871	97	8	10	10	NUM
dpc-4871	97	9	was	be	AUX
dpc-4871	97	10	found	find	VERB
dpc-4871	97	11	mainly	mainly	ADV
dpc-4871	97	12	for	for	ADP
dpc-4871	97	13	inhibitors	inhibitor	NOUN
dpc-4871	97	14	of	of	ADP
dpc-4871	97	15	il-23/17	il-23/17	PRON
dpc-4871	97	16	axis	axis	NOUN
dpc-4871	97	17	(	(	PUNCT
dpc-4871	97	18	guselkumab	guselkumab	NOUN
dpc-4871	97	19	[	[	X
dpc-4871	97	20	or	or	CCONJ
dpc-4871	97	21	0.497	0.497	NUM
dpc-4871	97	22	,	,	PUNCT
dpc-4871	97	23	95%ci	95%ci	NUM
dpc-4871	97	24	0.03	0.03	NUM
dpc-4871	97	25	-	-	SYM
dpc-4871	97	26	4.02	4.02	NUM
dpc-4871	97	27	,	,	PUNCT
dpc-4871	97	28	p	p	X
dpc-4871	97	29	=	=	NOUN
dpc-4871	97	30	0.030	0.030	NUM
dpc-4871	97	31	]	]	PUNCT
dpc-4871	97	32	,	,	PUNCT
dpc-4871	97	33	ixekizumab	ixekizumab	NOUN
dpc-4871	97	34	[	[	X
dpc-4871	97	35	or	or	CCONJ
dpc-4871	97	36	0.31	0.31	NUM
dpc-4871	97	37	,	,	PUNCT
dpc-4871	97	38	95%-ci	95%-ci	NUM
dpc-4871	97	39	0.09	0.09	NUM
dpc-4871	97	40	-	-	SYM
dpc-4871	97	41	2.71	2.71	NUM
dpc-4871	97	42	,	,	PUNCT
dpc-4871	97	43	p	p	X
dpc-4871	97	44	=	=	PUNCT
dpc-4871	97	45	0.025	0.025	NUM
dpc-4871	97	46	]	]	PUNCT
dpc-4871	97	47	,	,	PUNCT
dpc-4871	97	48	and	and	CCONJ
dpc-4871	97	49	risankizumab	risankizumab	VERB
dpc-4871	97	50	[	[	X
dpc-4871	97	51	or	or	CCONJ
dpc-4871	97	52	0.49	0.49	NUM
dpc-4871	97	53	,	,	PUNCT
dpc-4871	97	54	95%-ci	95%-ci	NUM
dpc-4871	97	55	0.03	0.03	NUM
dpc-4871	97	56	-	-	SYM
dpc-4871	97	57	4.02	4.02	NUM
dpc-4871	97	58	,	,	PUNCT
dpc-4871	97	59	p	p	X
dpc-4871	97	60	=	=	NOUN
dpc-4871	97	61	0.03	0.03	NUM
dpc-4871	97	62	]	]	PUNCT
dpc-4871	97	63	)	)	PUNCT
dpc-4871	97	64	(	(	PUNCT
dpc-4871	97	65	figure	figure	NOUN
dpc-4871	97	66	2	2	NUM
dpc-4871	97	67	)	)	PUNCT
dpc-4871	97	68	.	.	PUNCT
dpc-4871	98	1	in	in	ADP
dpc-4871	98	2	ppp	ppp	PROPN
dpc-4871	98	3	patients	patient	NOUN
dpc-4871	98	4	,	,	PUNCT
dpc-4871	98	5	the	the	DET
dpc-4871	98	6	use	use	NOUN
dpc-4871	98	7	of	of	ADP
dpc-4871	98	8	acitretin	acitretin	NOUN
dpc-4871	98	9	correlated	correlate	VERB
dpc-4871	98	10	significantly	significantly	ADV
dpc-4871	98	11	with	with	ADP
dpc-4871	98	12	a	a	DET
dpc-4871	98	13	dlqi	dlqi	NOUN
dpc-4871	98	14	<	<	X
dpc-4871	98	15	10	10	NUM
dpc-4871	98	16	(	(	PUNCT
dpc-4871	98	17	or	or	CCONJ
dpc-4871	98	18	1.80	1.80	NUM
dpc-4871	98	19	,	,	PUNCT
dpc-4871	98	20	95%-ci	95%-ci	NUM
dpc-4871	98	21	0.64	0.64	NUM
dpc-4871	98	22	-	-	SYM
dpc-4871	98	23	4.81	4.81	NUM
dpc-4871	98	24	,	,	PUNCT
dpc-4871	98	25	p	p	X
dpc-4871	98	26	=	=	NOUN
dpc-4871	98	27	0.046	0.046	NUM
dpc-4871	98	28	)	)	PUNCT
dpc-4871	98	29	and	and	CCONJ
dpc-4871	98	30	it	it	PRON
dpc-4871	98	31	was	be	AUX
dpc-4871	98	32	negatively	negatively	ADV
dpc-4871	98	33	associated	associate	VERB
dpc-4871	98	34	with	with	ADP
dpc-4871	98	35	qol	qol	PROPN
dpc-4871	98	36	impairment	impairment	NOUN
dpc-4871	98	37	(	(	PUNCT
dpc-4871	98	38	dlqi	dlqi	VERB
dpc-4871	98	39	≥	≥	NOUN
dpc-4871	98	40	10	10	NUM
dpc-4871	98	41	)	)	PUNCT
dpc-4871	98	42	(	(	PUNCT
dpc-4871	98	43	or	or	CCONJ
dpc-4871	98	44	0.42	0.42	NUM
dpc-4871	98	45	,	,	PUNCT
dpc-4871	98	46	95%-ci	95%-ci	NUM
dpc-4871	98	47	0.03	0.03	NUM
dpc-4871	98	48	-	-	SYM
dpc-4871	98	49	3.26	3.26	NUM
dpc-4871	98	50	,	,	PUNCT
dpc-4871	98	51	p	p	NOUN
dpc-4871	98	52	=	=	NOUN
dpc-4871	98	53	0.04	0.04	NUM
dpc-4871	98	54	)	)	PUNCT
dpc-4871	98	55	.	.	PUNCT
dpc-4871	99	1	in	in	ADP
dpc-4871	99	2	contrast	contrast	NOUN
dpc-4871	99	3	,	,	PUNCT
dpc-4871	99	4	il17a	il17a	PROPN
dpc-4871	99	5	and	and	CCONJ
dpc-4871	99	6	pde4	pde4	NOUN
dpc-4871	99	7	inhibitors	inhibitor	NOUN
dpc-4871	99	8	were	be	AUX
dpc-4871	99	9	favored	favor	VERB
dpc-4871	99	10	in	in	ADP
dpc-4871	99	11	ppp	ppp	NOUN
dpc-4871	99	12	with	with	ADP
dpc-4871	99	13	dlqi	dlqi	PROPN
dpc-4871	99	14	≥	≥	PROPN
dpc-4871	99	15	10	10	NUM
dpc-4871	99	16	[	[	X
dpc-4871	99	17	(	(	PUNCT
dpc-4871	99	18	secukinumab	secukinumab	NOUN
dpc-4871	99	19	[	[	X
dpc-4871	99	20	or	or	CCONJ
dpc-4871	99	21	2.85	2.85	NUM
dpc-4871	99	22	,	,	PUNCT
dpc-4871	99	23	95%-ci	95%-ci	NUM
dpc-4871	99	24	0.73	0.73	NUM
dpc-4871	99	25	-	-	SYM
dpc-4871	99	26	12.66	12.66	NUM
dpc-4871	99	27	,	,	PUNCT
dpc-4871	99	28	p	p	NOUN
dpc-4871	99	29	=	=	NOUN
dpc-4871	99	30	0.024	0.024	NUM
dpc-4871	99	31	]	]	PUNCT
dpc-4871	99	32	and	and	CCONJ
dpc-4871	99	33	apremilast	apremilast	VERB
dpc-4871	99	34	(	(	PUNCT
dpc-4871	99	35	[	[	X
dpc-4871	99	36	or	or	CCONJ
dpc-4871	99	37	4.28	4.28	NUM
dpc-4871	99	38	,	,	PUNCT
dpc-4871	99	39	95%-ci	95%-ci	NUM
dpc-4871	99	40	0.56	0.56	NUM
dpc-4871	99	41	-	-	SYM
dpc-4871	99	42	9.62	9.62	NUM
dpc-4871	99	43	,	,	PUNCT
dpc-4871	99	44	p	p	X
dpc-4871	99	45	=	=	NOUN
dpc-4871	99	46	0.008	0.008	NUM
dpc-4871	99	47	]	]	PUNCT
dpc-4871	99	48	)	)	PUNCT
dpc-4871	99	49	(	(	PUNCT
dpc-4871	99	50	figure	figure	NOUN
dpc-4871	99	51	3	3	NUM
dpc-4871	99	52	)	)	PUNCT
dpc-4871	99	53	.	.	PUNCT
dpc-4871	100	1	in	in	ADP
dpc-4871	100	2	order	order	NOUN
dpc-4871	100	3	to	to	PART
dpc-4871	100	4	explore	explore	VERB
dpc-4871	100	5	eventual	eventual	ADJ
dpc-4871	100	6	effects	effect	NOUN
dpc-4871	100	7	of	of	ADP
dpc-4871	100	8	treatment	treatment	NOUN
dpc-4871	100	9	time	time	NOUN
dpc-4871	100	10	,	,	PUNCT
dpc-4871	100	11	we	we	PRON
dpc-4871	100	12	determined	determine	VERB
dpc-4871	100	13	mean	mean	VERB
dpc-4871	100	14	duration	duration	NOUN
dpc-4871	100	15	of	of	ADP
dpc-4871	100	16	ongoing	ongoing	ADJ
dpc-4871	100	17	therapies	therapy	NOUN
dpc-4871	100	18	that	that	PRON
dpc-4871	100	19	resulted	result	VERB
dpc-4871	100	20	to	to	ADP
dpc-4871	100	21	significant	significant	ADJ
dpc-4871	100	22	alter	alter	NOUN
dpc-4871	100	23	qol	qol	NOUN
dpc-4871	100	24	in	in	ADP
dpc-4871	100	25	our	our	PRON
dpc-4871	100	26	sample	sample	NOUN
dpc-4871	100	27	.	.	PUNCT
dpc-4871	101	1	gpp	gpp	NOUN
dpc-4871	101	2	+	+	CCONJ
dpc-4871	101	3	pso	pso	NOUN
dpc-4871	101	4	patients	patient	NOUN
dpc-4871	101	5	were	be	AUX
dpc-4871	101	6	administered	administer	VERB
dpc-4871	101	7	with	with	ADP
dpc-4871	101	8	certolizumab	certolizumab	NOUN
dpc-4871	101	9	,	,	PUNCT
dpc-4871	101	10	etanercept	etanercept	NOUN
dpc-4871	101	11	,	,	PUNCT
dpc-4871	101	12	secukinumab	secukinumab	NOUN
dpc-4871	101	13	and	and	CCONJ
dpc-4871	101	14	ustekinumab	ustekinumab	NOUN
dpc-4871	101	15	respectively	respectively	ADV
dpc-4871	101	16	for	for	ADP
dpc-4871	101	17	37.5	37.5	NUM
dpc-4871	101	18	,	,	PUNCT
dpc-4871	101	19	74.3	74.3	NUM
dpc-4871	101	20	,	,	PUNCT
dpc-4871	101	21	23.8	23.8	NUM
dpc-4871	101	22	and	and	CCONJ
dpc-4871	101	23	50.1	50.1	NUM
dpc-4871	101	24	months	month	NOUN
dpc-4871	101	25	.	.	PUNCT
dpc-4871	102	1	ppp	ppp	NOUN
dpc-4871	102	2	patients	patient	NOUN
dpc-4871	102	3	were	be	AUX
dpc-4871	102	4	administered	administer	VERB
dpc-4871	102	5	with	with	ADP
dpc-4871	102	6	acitretin	acitretin	NOUN
dpc-4871	102	7	and	and	CCONJ
dpc-4871	102	8	secukinumab	secukinumab	NOUN
dpc-4871	102	9	respectively	respectively	ADV
dpc-4871	102	10	for	for	ADP
dpc-4871	102	11	68.9	68.9	NUM
dpc-4871	102	12	and	and	CCONJ
dpc-4871	102	13	25.6	25.6	NUM
dpc-4871	102	14	months	month	NOUN
dpc-4871	102	15	.	.	PUNCT
dpc-4871	103	1	discussion	discussion	NOUN
dpc-4871	103	2	the	the	DET
dpc-4871	103	3	current	current	ADJ
dpc-4871	103	4	therapeutic	therapeutic	ADJ
dpc-4871	103	5	management	management	NOUN
dpc-4871	103	6	of	of	ADP
dpc-4871	103	7	pp	pp	ADV
dpc-4871	103	8	contemplates	contemplate	VERB
dpc-4871	103	9	different	different	ADJ
dpc-4871	103	10	treatment	treatment	NOUN
dpc-4871	103	11	options	option	NOUN
dpc-4871	103	12	,	,	PUNCT
dpc-4871	103	13	but	but	CCONJ
dpc-4871	103	14	very	very	ADV
dpc-4871	103	15	few	few	ADJ
dpc-4871	103	16	with	with	ADP
dpc-4871	103	17	approved	approve	VERB
dpc-4871	103	18	indication	indication	NOUN
dpc-4871	103	19	up	up	ADP
dpc-4871	103	20	to	to	ADP
dpc-4871	103	21	now	now	ADV
dpc-4871	103	22	[	[	X
dpc-4871	103	23	4	4	NUM
dpc-4871	103	24	]	]	PUNCT
dpc-4871	103	25	.	.	PUNCT
dpc-4871	104	1	we	we	PRON
dpc-4871	104	2	have	have	AUX
dpc-4871	104	3	performed	perform	VERB
dpc-4871	104	4	an	an	DET
dpc-4871	104	5	analysis	analysis	NOUN
dpc-4871	104	6	of	of	ADP
dpc-4871	104	7	pp	pp	ADP
dpc-4871	104	8	patient	patient	ADJ
dpc-4871	104	9	characteristics	characteristic	NOUN
dpc-4871	104	10	,	,	PUNCT
dpc-4871	104	11	drugs	drug	NOUN
dpc-4871	104	12	and	and	CCONJ
dpc-4871	104	13	impact	impact	NOUN
dpc-4871	104	14	on	on	ADP
dpc-4871	104	15	qol	qol	NOUN
dpc-4871	104	16	at	at	ADP
dpc-4871	104	17	our	our	PRON
dpc-4871	104	18	unit	unit	NOUN
dpc-4871	104	19	including	include	VERB
dpc-4871	104	20	data	datum	NOUN
dpc-4871	104	21	referred	refer	VERB
dpc-4871	104	22	to	to	ADP
dpc-4871	104	23	a	a	DET
dpc-4871	104	24	period	period	NOUN
dpc-4871	104	25	of	of	ADP
dpc-4871	104	26	5	5	NUM
dpc-4871	104	27	years	year	NOUN
dpc-4871	104	28	to	to	PART
dpc-4871	104	29	explore	explore	VERB
dpc-4871	104	30	which	which	PRON
dpc-4871	104	31	is	be	AUX
dpc-4871	104	32	the	the	DET
dpc-4871	104	33	current	current	ADJ
dpc-4871	104	34	therapeutic	therapeutic	ADJ
dpc-4871	104	35	approach	approach	NOUN
dpc-4871	104	36	in	in	ADP
dpc-4871	104	37	real	real	ADJ
dpc-4871	104	38	life	life	NOUN
dpc-4871	104	39	trying	try	VERB
dpc-4871	104	40	to	to	PART
dpc-4871	104	41	reveal	reveal	VERB
dpc-4871	104	42	which	which	DET
dpc-4871	104	43	factors	factor	NOUN
dpc-4871	104	44	can	can	AUX
dpc-4871	104	45	influence	influence	VERB
dpc-4871	104	46	the	the	DET
dpc-4871	104	47	treatment	treatment	NOUN
dpc-4871	104	48	options	option	NOUN
dpc-4871	104	49	.	.	PUNCT
dpc-4871	105	1	it	it	PRON
dpc-4871	105	2	is	be	AUX
dpc-4871	105	3	now	now	ADV
dpc-4871	105	4	established	establish	VERB
dpc-4871	105	5	that	that	SCONJ
dpc-4871	105	6	pp	pp	PROPN
dpc-4871	105	7	affects	affect	VERB
dpc-4871	105	8	more	more	ADV
dpc-4871	105	9	frequently	frequently	ADV
dpc-4871	105	10	the	the	DET
dpc-4871	105	11	middle	middle	ADJ
dpc-4871	105	12	-	-	PUNCT
dpc-4871	105	13	aged	aged	ADJ
dpc-4871	105	14	adult	adult	NOUN
dpc-4871	105	15	population	population	NOUN
dpc-4871	105	16	with	with	ADP
dpc-4871	105	17	a	a	DET
dpc-4871	105	18	predilection	predilection	NOUN
dpc-4871	105	19	for	for	ADP
dpc-4871	105	20	female	female	ADJ
dpc-4871	105	21	gender	gender	NOUN
dpc-4871	105	22	[	[	X
dpc-4871	105	23	17	17	NUM
dpc-4871	105	24	]	]	PUNCT
dpc-4871	105	25	.	.	PUNCT
dpc-4871	106	1	comorbidities	comorbiditie	NOUN
dpc-4871	106	2	most	most	ADV
dpc-4871	106	3	often	often	ADV
dpc-4871	106	4	encountered	encounter	VERB
dpc-4871	106	5	in	in	ADP
dpc-4871	106	6	these	these	DET
dpc-4871	106	7	patients	patient	NOUN
dpc-4871	106	8	concern	concern	VERB
dpc-4871	106	9	an	an	DET
dpc-4871	106	10	increase	increase	NOUN
dpc-4871	106	11	in	in	ADP
dpc-4871	106	12	bmi	bmi	NOUN
dpc-4871	106	13	and	and	CCONJ
dpc-4871	106	14	diseases	disease	NOUN
dpc-4871	106	15	of	of	ADP
dpc-4871	106	16	the	the	DET
dpc-4871	106	17	cardiovascular	cardiovascular	ADJ
dpc-4871	106	18	original	original	ADJ
dpc-4871	106	19	article	article	NOUN
dpc-4871	106	20	|	|	ADV
dpc-4871	106	21	dermatol	dermatol	ADJ
dpc-4871	106	22	pract	pract	NOUN
dpc-4871	106	23	concept	concept	NOUN
dpc-4871	106	24	.	.	PUNCT
dpc-4871	107	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	107	2	5	5	NUM
dpc-4871	107	3	treatment	treatment	NOUN
dpc-4871	107	4	.	.	PUNCT
dpc-4871	108	1	there	there	PRON
dpc-4871	108	2	were	be	VERB
dpc-4871	108	3	6	6	NUM
dpc-4871	108	4	ppp	ppp	NOUN
dpc-4871	108	5	subjects	subject	NOUN
dpc-4871	108	6	(	(	PUNCT
dpc-4871	108	7	13	13	NUM
dpc-4871	108	8	%	%	NOUN
dpc-4871	108	9	)	)	PUNCT
dpc-4871	108	10	and	and	CCONJ
dpc-4871	108	11	5	5	NUM
dpc-4871	108	12	gpp	gpp	NOUN
dpc-4871	108	13	+	+	CCONJ
dpc-4871	108	14	pso	pso	NOUN
dpc-4871	108	15	subjects	subject	NOUN
dpc-4871	108	16	(	(	PUNCT
dpc-4871	108	17	8	8	NUM
dpc-4871	108	18	%	%	NOUN
dpc-4871	108	19	)	)	PUNCT
dpc-4871	108	20	with	with	ADP
dpc-4871	108	21	a	a	DET
dpc-4871	108	22	moderate	moderate	ADJ
dpc-4871	108	23	disease	disease	NOUN
dpc-4871	108	24	by	by	ADP
dpc-4871	108	25	pppga	pppga	NOUN
dpc-4871	108	26	and	and	CCONJ
dpc-4871	108	27	gppga	gppga	NOUN
dpc-4871	108	28	,	,	PUNCT
dpc-4871	108	29	respectively	respectively	ADV
dpc-4871	108	30	,	,	PUNCT
dpc-4871	108	31	since	since	SCONJ
dpc-4871	108	32	the	the	DET
dpc-4871	108	33	score	score	NOUN
dpc-4871	108	34	was	be	AUX
dpc-4871	108	35	≥2.5	≥2.5	NOUN
dpc-4871	108	36	.	.	PUNCT
dpc-4871	109	1	no	no	DET
dpc-4871	109	2	significant	significant	ADJ
dpc-4871	109	3	difference	difference	NOUN
dpc-4871	109	4	in	in	ADP
dpc-4871	109	5	disease	disease	NOUN
dpc-4871	109	6	severity	severity	NOUN
dpc-4871	109	7	for	for	ADP
dpc-4871	109	8	ppp	ppp	NOUN
dpc-4871	109	9	and	and	CCONJ
dpc-4871	109	10	gpp	gpp	NOUN
dpc-4871	109	11	+	+	CCONJ
dpc-4871	109	12	pso	pso	NOUN
dpc-4871	109	13	was	be	AUX
dpc-4871	109	14	observed	observe	VERB
dpc-4871	109	15	.	.	PUNCT
dpc-4871	110	1	despite	despite	SCONJ
dpc-4871	110	2	no	no	DET
dpc-4871	110	3	severe	severe	ADJ
dpc-4871	110	4	forms	form	NOUN
dpc-4871	110	5	of	of	ADP
dpc-4871	110	6	the	the	DET
dpc-4871	110	7	diseases	disease	NOUN
dpc-4871	110	8	,	,	PUNCT
dpc-4871	110	9	we	we	PRON
dpc-4871	110	10	found	find	VERB
dpc-4871	110	11	a	a	DET
dpc-4871	110	12	great	great	ADJ
dpc-4871	110	13	impact	impact	NOUN
dpc-4871	110	14	on	on	ADP
dpc-4871	110	15	qol	qol	PROPN
dpc-4871	110	16	.	.	PUNCT
dpc-4871	111	1	indeed	indeed	ADV
dpc-4871	111	2	,	,	PUNCT
dpc-4871	111	3	11	11	NUM
dpc-4871	111	4	ppp	ppp	NOUN
dpc-4871	111	5	(	(	PUNCT
dpc-4871	111	6	24	24	NUM
dpc-4871	111	7	%	%	NOUN
dpc-4871	111	8	)	)	PUNCT
dpc-4871	111	9	and	and	CCONJ
dpc-4871	111	10	28	28	NUM
dpc-4871	111	11	gpp	gpp	NOUN
dpc-4871	111	12	+	+	X
dpc-4871	111	13	pso	pso	NOUN
dpc-4871	111	14	(	(	PUNCT
dpc-4871	111	15	45	45	NUM
dpc-4871	111	16	%	%	NOUN
dpc-4871	111	17	)	)	PUNCT
dpc-4871	111	18	subjects	subject	NOUN
dpc-4871	111	19	showed	show	VERB
dpc-4871	111	20	a	a	DET
dpc-4871	111	21	dlqi	dlqi	ADJ
dpc-4871	111	22	≥10	≥10	PROPN
dpc-4871	111	23	.	.	PUNCT
dpc-4871	111	24	analyzing	analyze	VERB
dpc-4871	111	25	current	current	ADJ
dpc-4871	111	26	systemic	systemic	ADJ
dpc-4871	111	27	treatments	treatment	NOUN
dpc-4871	111	28	of	of	ADP
dpc-4871	111	29	our	our	PRON
dpc-4871	111	30	population	population	NOUN
dpc-4871	111	31	,	,	PUNCT
dpc-4871	111	32	we	we	PRON
dpc-4871	111	33	can	can	AUX
dpc-4871	111	34	assess	assess	VERB
dpc-4871	111	35	that	that	SCONJ
dpc-4871	111	36	non	non	ADJ
dpc-4871	111	37	-	-	ADJ
dpc-4871	111	38	biological	biological	ADJ
dpc-4871	111	39	systemic	systemic	ADJ
dpc-4871	111	40	therapy	therapy	NOUN
dpc-4871	111	41	represents	represent	VERB
dpc-4871	111	42	the	the	DET
dpc-4871	111	43	first	first	ADJ
dpc-4871	111	44	choice	choice	NOUN
dpc-4871	111	45	both	both	PRON
dpc-4871	111	46	for	for	ADP
dpc-4871	111	47	ppp	ppp	NOUN
dpc-4871	111	48	and	and	CCONJ
dpc-4871	111	49	gpp	gpp	NOUN
dpc-4871	111	50	+	+	CCONJ
dpc-4871	111	51	pso	pso	NOUN
dpc-4871	111	52	despite	despite	SCONJ
dpc-4871	111	53	the	the	DET
dpc-4871	111	54	progress	progress	NOUN
dpc-4871	111	55	made	make	VERB
dpc-4871	111	56	by	by	ADP
dpc-4871	111	57	biologics	biologic	NOUN
dpc-4871	111	58	.	.	PUNCT
dpc-4871	112	1	almost	almost	ADV
dpc-4871	112	2	half	half	NOUN
dpc-4871	112	3	(	(	PUNCT
dpc-4871	112	4	43	43	NUM
dpc-4871	112	5	%	%	NOUN
dpc-4871	112	6	)	)	PUNCT
dpc-4871	112	7	of	of	ADP
dpc-4871	112	8	ppp	ppp	NOUN
dpc-4871	112	9	patients	patient	NOUN
dpc-4871	112	10	(	(	PUNCT
dpc-4871	112	11	20	20	NUM
dpc-4871	112	12	out	out	ADP
dpc-4871	112	13	of	of	ADP
dpc-4871	112	14	46	46	NUM
dpc-4871	112	15	)	)	PUNCT
dpc-4871	112	16	and	and	CCONJ
dpc-4871	112	17	60	60	NUM
dpc-4871	112	18	%	%	NOUN
dpc-4871	112	19	of	of	ADP
dpc-4871	112	20	gpp	gpp	NOUN
dpc-4871	112	21	+	+	CCONJ
dpc-4871	112	22	pso	pso	NOUN
dpc-4871	112	23	patients	patient	NOUN
dpc-4871	112	24	(	(	PUNCT
dpc-4871	112	25	37	37	NUM
dpc-4871	112	26	out	out	ADP
dpc-4871	112	27	of	of	ADP
dpc-4871	112	28	62	62	NUM
dpc-4871	112	29	)	)	PUNCT
dpc-4871	112	30	were	be	AUX
dpc-4871	112	31	treated	treat	VERB
dpc-4871	112	32	with	with	ADP
dpc-4871	112	33	nonbiological	nonbiological	ADJ
dpc-4871	112	34	systemic	systemic	ADJ
dpc-4871	112	35	drugs	drug	NOUN
dpc-4871	112	36	.	.	PUNCT
dpc-4871	113	1	our	our	PRON
dpc-4871	113	2	findings	finding	NOUN
dpc-4871	113	3	fit	fit	VERB
dpc-4871	113	4	with	with	ADP
dpc-4871	113	5	a	a	DET
dpc-4871	113	6	quite	quite	ADV
dpc-4871	113	7	recent	recent	ADJ
dpc-4871	113	8	analysis	analysis	NOUN
dpc-4871	113	9	performed	perform	VERB
dpc-4871	113	10	by	by	ADP
dpc-4871	113	11	menter	menter	PROPN
dpc-4871	113	12	et	et	PROPN
dpc-4871	113	13	al	al	PROPN
dpc-4871	114	1	[	[	X
dpc-4871	114	2	9	9	NUM
dpc-4871	114	3	]	]	PUNCT
dpc-4871	114	4	.	.	PUNCT
dpc-4871	115	1	in	in	ADP
dpc-4871	115	2	particular	particular	ADJ
dpc-4871	115	3	,	,	PUNCT
dpc-4871	115	4	it	it	PRON
dpc-4871	115	5	has	have	AUX
dpc-4871	115	6	been	be	AUX
dpc-4871	115	7	reported	report	VERB
dpc-4871	115	8	that	that	SCONJ
dpc-4871	115	9	among	among	ADP
dpc-4871	115	10	current	current	ADJ
dpc-4871	115	11	systemic	systemic	ADJ
dpc-4871	115	12	nonbiological	nonbiological	ADJ
dpc-4871	115	13	therapy	therapy	NOUN
dpc-4871	115	14	,	,	PUNCT
dpc-4871	115	15	acitretin	acitretin	NOUN
dpc-4871	115	16	remains	remain	VERB
dpc-4871	115	17	the	the	DET
dpc-4871	115	18	and	and	CCONJ
dpc-4871	115	19	metabolic	metabolic	NOUN
dpc-4871	115	20	system	system	NOUN
dpc-4871	115	21	(	(	PUNCT
dpc-4871	115	22	primarily	primarily	ADV
dpc-4871	115	23	arterial	arterial	ADJ
dpc-4871	115	24	hypertension	hypertension	NOUN
dpc-4871	115	25	,	,	PUNCT
dpc-4871	115	26	followed	follow	VERB
dpc-4871	115	27	by	by	ADP
dpc-4871	115	28	dyslipidemia	dyslipidemia	NOUN
dpc-4871	115	29	and	and	CCONJ
dpc-4871	115	30	diabetes	diabetes	NOUN
dpc-4871	115	31	mellitus	mellitus	NOUN
dpc-4871	115	32	)	)	PUNCT
dpc-4871	115	33	.	.	PUNCT
dpc-4871	116	1	moreover	moreover	ADV
dpc-4871	116	2	,	,	PUNCT
dpc-4871	116	3	as	as	SCONJ
dpc-4871	116	4	described	describe	VERB
dpc-4871	116	5	by	by	ADP
dpc-4871	116	6	pfohler	pfohler	NOUN
dpc-4871	116	7	et	et	PROPN
dpc-4871	116	8	al	al	PROPN
dpc-4871	117	1	[	[	X
dpc-4871	117	2	18	18	NUM
dpc-4871	117	3	]	]	PUNCT
dpc-4871	117	4	,	,	PUNCT
dpc-4871	117	5	psoriatic	psoriatic	ADJ
dpc-4871	117	6	arthritis	arthritis	NOUN
dpc-4871	117	7	(	(	PUNCT
dpc-4871	117	8	psa	psa	NOUN
dpc-4871	117	9	)	)	PUNCT
dpc-4871	117	10	and	and	CCONJ
dpc-4871	117	11	inflammatory	inflammatory	ADJ
dpc-4871	117	12	bowel	bowel	NOUN
dpc-4871	117	13	disease	disease	NOUN
dpc-4871	117	14	(	(	PUNCT
dpc-4871	117	15	ibd	ibd	PROPN
dpc-4871	117	16	)	)	PUNCT
dpc-4871	117	17	are	be	AUX
dpc-4871	117	18	found	find	VERB
dpc-4871	117	19	with	with	ADP
dpc-4871	117	20	a	a	DET
dpc-4871	117	21	lower	low	ADJ
dpc-4871	117	22	incidence	incidence	NOUN
dpc-4871	117	23	in	in	ADP
dpc-4871	117	24	association	association	NOUN
dpc-4871	117	25	with	with	ADP
dpc-4871	117	26	pp	pp	ADP
dpc-4871	117	27	patients	patient	NOUN
dpc-4871	117	28	,	,	PUNCT
dpc-4871	117	29	unlike	unlike	ADP
dpc-4871	117	30	plaque	plaque	NOUN
dpc-4871	117	31	psoriasis	psoriasis	NOUN
dpc-4871	117	32	.	.	PUNCT
dpc-4871	118	1	this	this	PRON
dpc-4871	118	2	is	be	AUX
dpc-4871	118	3	in	in	ADP
dpc-4871	118	4	line	line	NOUN
dpc-4871	118	5	with	with	ADP
dpc-4871	118	6	our	our	PRON
dpc-4871	118	7	population	population	NOUN
dpc-4871	118	8	characteristics	characteristic	NOUN
dpc-4871	118	9	,	,	PUNCT
dpc-4871	118	10	even	even	ADV
dpc-4871	118	11	though	though	SCONJ
dpc-4871	118	12	among	among	ADP
dpc-4871	118	13	analyzed	analyze	VERB
dpc-4871	118	14	subjects	subject	NOUN
dpc-4871	118	15	,	,	PUNCT
dpc-4871	118	16	we	we	PRON
dpc-4871	118	17	included	include	VERB
dpc-4871	118	18	pp	pp	ADP
dpc-4871	118	19	both	both	PRON
dpc-4871	118	20	in	in	ADP
dpc-4871	118	21	the	the	DET
dpc-4871	118	22	absolute	absolute	ADJ
dpc-4871	118	23	palmoplantar	palmoplantar	NOUN
dpc-4871	118	24	subtype	subtype	NOUN
dpc-4871	118	25	(	(	PUNCT
dpc-4871	118	26	ppp	ppp	NOUN
dpc-4871	118	27	)	)	PUNCT
dpc-4871	118	28	and	and	CCONJ
dpc-4871	118	29	in	in	ADP
dpc-4871	118	30	the	the	DET
dpc-4871	118	31	generalized	generalized	ADJ
dpc-4871	118	32	form	form	NOUN
dpc-4871	118	33	associated	associate	VERB
dpc-4871	118	34	with	with	ADP
dpc-4871	118	35	psoriasis	psoriasis	NOUN
dpc-4871	118	36	(	(	PUNCT
dpc-4871	118	37	gpp	gpp	NOUN
dpc-4871	118	38	+	+	CCONJ
dpc-4871	118	39	pso	pso	NOUN
dpc-4871	118	40	)	)	PUNCT
dpc-4871	118	41	.	.	PUNCT
dpc-4871	119	1	the	the	DET
dpc-4871	119	2	prevalence	prevalence	NOUN
dpc-4871	119	3	of	of	ADP
dpc-4871	119	4	these	these	DET
dpc-4871	119	5	2	2	NUM
dpc-4871	119	6	conditions	condition	NOUN
dpc-4871	119	7	is	be	AUX
dpc-4871	119	8	not	not	PART
dpc-4871	119	9	homogeneous	homogeneous	ADJ
dpc-4871	119	10	:	:	PUNCT
dpc-4871	119	11	some	some	DET
dpc-4871	119	12	authors	author	NOUN
dpc-4871	119	13	[	[	X
dpc-4871	119	14	17	17	NUM
dpc-4871	119	15	]	]	PUNCT
dpc-4871	119	16	report	report	NOUN
dpc-4871	119	17	a	a	DET
dpc-4871	119	18	greater	great	ADJ
dpc-4871	119	19	prevalence	prevalence	NOUN
dpc-4871	119	20	of	of	ADP
dpc-4871	119	21	gpp	gpp	NOUN
dpc-4871	119	22	,	,	PUNCT
dpc-4871	119	23	other	other	ADJ
dpc-4871	119	24	ones	one	NOUN
dpc-4871	119	25	[	[	X
dpc-4871	119	26	3	3	X
dpc-4871	119	27	]	]	PUNCT
dpc-4871	119	28	a	a	DET
dpc-4871	119	29	greater	great	ADJ
dpc-4871	119	30	frequency	frequency	NOUN
dpc-4871	119	31	of	of	ADP
dpc-4871	119	32	the	the	DET
dpc-4871	119	33	ppp	ppp	NOUN
dpc-4871	119	34	subtype	subtype	NOUN
dpc-4871	119	35	.	.	PUNCT
dpc-4871	120	1	in	in	ADP
dpc-4871	120	2	our	our	PRON
dpc-4871	120	3	analysis	analysis	NOUN
dpc-4871	120	4	,	,	PUNCT
dpc-4871	120	5	we	we	PRON
dpc-4871	120	6	included	include	VERB
dpc-4871	120	7	patients	patient	NOUN
dpc-4871	120	8	with	with	ADP
dpc-4871	120	9	both	both	DET
dpc-4871	120	10	subtypes	subtype	NOUN
dpc-4871	120	11	regardless	regardless	ADV
dpc-4871	120	12	the	the	DET
dpc-4871	120	13	severity	severity	NOUN
dpc-4871	120	14	.	.	PUNCT
dpc-4871	121	1	our	our	PRON
dpc-4871	121	2	patients	patient	NOUN
dpc-4871	121	3	showed	show	VERB
dpc-4871	121	4	mild	mild	ADJ
dpc-4871	121	5	disease	disease	NOUN
dpc-4871	121	6	globally	globally	ADV
dpc-4871	121	7	(	(	PUNCT
dpc-4871	121	8	both	both	CCONJ
dpc-4871	121	9	ppp	ppp	NOUN
dpc-4871	121	10	and	and	CCONJ
dpc-4871	121	11	gpp	gpp	NOUN
dpc-4871	121	12	+	+	CCONJ
dpc-4871	121	13	pso	pso	NOUN
dpc-4871	121	14	)	)	PUNCT
dpc-4871	121	15	in	in	ADP
dpc-4871	121	16	terms	term	NOUN
dpc-4871	121	17	of	of	ADP
dpc-4871	121	18	pppasi	pppasi	NOUN
dpc-4871	121	19	and	and	CCONJ
dpc-4871	121	20	gppasi	gppasi	NOUN
dpc-4871	121	21	,	,	PUNCT
dpc-4871	121	22	respectively	respectively	ADV
dpc-4871	121	23	,	,	PUNCT
dpc-4871	121	24	but	but	CCONJ
dpc-4871	121	25	it	it	PRON
dpc-4871	121	26	has	have	VERB
dpc-4871	121	27	to	to	PART
dpc-4871	121	28	be	be	AUX
dpc-4871	121	29	taken	take	VERB
dpc-4871	121	30	into	into	ADP
dpc-4871	121	31	account	account	NOUN
dpc-4871	121	32	that	that	SCONJ
dpc-4871	121	33	all	all	DET
dpc-4871	121	34	patients	patient	NOUN
dpc-4871	121	35	were	be	AUX
dpc-4871	121	36	on	on	ADP
dpc-4871	121	37	figure	figure	NOUN
dpc-4871	121	38	2	2	NUM
dpc-4871	121	39	.	.	PUNCT
dpc-4871	121	40	systemic	systemic	ADJ
dpc-4871	121	41	therapies	therapy	NOUN
dpc-4871	121	42	associated	associate	VERB
dpc-4871	121	43	with	with	ADP
dpc-4871	121	44	dermatology	dermatology	NOUN
dpc-4871	121	45	life	life	NOUN
dpc-4871	121	46	quality	quality	NOUN
dpc-4871	121	47	index	index	NOUN
dpc-4871	121	48	(	(	PUNCT
dpc-4871	121	49	dlqi	dlqi	ADJ
dpc-4871	121	50	)	)	PUNCT
dpc-4871	121	51	categories	category	NOUN
dpc-4871	121	52	(	(	PUNCT
dpc-4871	121	53	<	<	X
dpc-4871	121	54	10	10	NUM
dpc-4871	121	55	and	and	CCONJ
dpc-4871	121	56	≥10	≥10	ADJ
dpc-4871	121	57	)	)	PUNCT
dpc-4871	121	58	in	in	ADP
dpc-4871	121	59	patients	patient	NOUN
dpc-4871	121	60	with	with	ADP
dpc-4871	121	61	generalized	generalized	ADJ
dpc-4871	121	62	pustular	pustular	ADJ
dpc-4871	121	63	psoriasis	psoriasis	NOUN
dpc-4871	121	64	and	and	CCONJ
dpc-4871	121	65	plaque	plaque	NOUN
dpc-4871	121	66	psoriasis	psoriasis	NOUN
dpc-4871	121	67	(	(	PUNCT
dpc-4871	121	68	gpp	gpp	NOUN
dpc-4871	121	69	+	+	CCONJ
dpc-4871	121	70	pso	pso	NOUN
dpc-4871	121	71	)	)	PUNCT
dpc-4871	121	72	.	.	PUNCT
dpc-4871	122	1	odds	odd	NOUN
dpc-4871	122	2	ratios	ratio	NOUN
dpc-4871	122	3	(	(	PUNCT
dpc-4871	122	4	or	or	CCONJ
dpc-4871	122	5	)	)	PUNCT
dpc-4871	122	6	and	and	CCONJ
dpc-4871	122	7	95	95	NUM
dpc-4871	122	8	%	%	NOUN
dpc-4871	122	9	confidence	confidence	NOUN
dpc-4871	122	10	intervals	interval	NOUN
dpc-4871	122	11	(	(	PUNCT
dpc-4871	122	12	ci	ci	NOUN
dpc-4871	122	13	)	)	PUNCT
dpc-4871	122	14	are	be	AUX
dpc-4871	122	15	depicted	depict	VERB
dpc-4871	122	16	.	.	PUNCT
dpc-4871	123	1	orange	orange	PROPN
dpc-4871	123	2	plots	plot	NOUN
dpc-4871	123	3	indicate	indicate	VERB
dpc-4871	123	4	a	a	DET
dpc-4871	123	5	statistically	statistically	ADV
dpc-4871	123	6	significant	significant	ADJ
dpc-4871	123	7	association	association	NOUN
dpc-4871	123	8	.	.	PUNCT
dpc-4871	124	1	figure	figure	VERB
dpc-4871	124	2	3	3	NUM
dpc-4871	124	3	.	.	PUNCT
dpc-4871	125	1	systemic	systemic	ADJ
dpc-4871	125	2	therapies	therapy	NOUN
dpc-4871	125	3	associated	associate	VERB
dpc-4871	125	4	with	with	ADP
dpc-4871	125	5	dermatology	dermatology	NOUN
dpc-4871	125	6	life	life	NOUN
dpc-4871	125	7	quality	quality	NOUN
dpc-4871	125	8	index	index	NOUN
dpc-4871	125	9	(	(	PUNCT
dpc-4871	125	10	dlqi	dlqi	ADJ
dpc-4871	125	11	)	)	PUNCT
dpc-4871	125	12	categories	category	NOUN
dpc-4871	125	13	(	(	PUNCT
dpc-4871	125	14	<	<	X
dpc-4871	125	15	10	10	NUM
dpc-4871	125	16	and	and	CCONJ
dpc-4871	125	17	≥10	≥10	ADJ
dpc-4871	125	18	)	)	PUNCT
dpc-4871	125	19	in	in	ADP
dpc-4871	125	20	patients	patient	NOUN
dpc-4871	125	21	with	with	ADP
dpc-4871	125	22	palmoplantar	palmoplantar	NOUN
dpc-4871	125	23	pustulosis	pustulosis	NOUN
dpc-4871	125	24	(	(	PUNCT
dpc-4871	125	25	ppp	ppp	NOUN
dpc-4871	125	26	)	)	PUNCT
dpc-4871	125	27	.	.	PUNCT
dpc-4871	126	1	odds	odd	NOUN
dpc-4871	126	2	ratios	ratio	NOUN
dpc-4871	126	3	(	(	PUNCT
dpc-4871	126	4	or	or	CCONJ
dpc-4871	126	5	)	)	PUNCT
dpc-4871	126	6	and	and	CCONJ
dpc-4871	126	7	95	95	NUM
dpc-4871	126	8	%	%	NOUN
dpc-4871	126	9	confidence	confidence	NOUN
dpc-4871	126	10	intervals	interval	NOUN
dpc-4871	126	11	(	(	PUNCT
dpc-4871	126	12	ci	ci	NOUN
dpc-4871	126	13	)	)	PUNCT
dpc-4871	126	14	are	be	AUX
dpc-4871	126	15	depicted	depict	VERB
dpc-4871	126	16	.	.	PUNCT
dpc-4871	127	1	orange	orange	PROPN
dpc-4871	127	2	plots	plot	NOUN
dpc-4871	127	3	indicate	indicate	VERB
dpc-4871	127	4	a	a	DET
dpc-4871	127	5	statistically	statistically	ADV
dpc-4871	127	6	significant	significant	ADJ
dpc-4871	127	7	association	association	NOUN
dpc-4871	127	8	.	.	PUNCT
dpc-4871	128	1	6	6	NUM
dpc-4871	128	2	original	original	ADJ
dpc-4871	128	3	article	article	NOUN
dpc-4871	128	4	|	|	ADV
dpc-4871	128	5	dermatol	dermatol	ADJ
dpc-4871	128	6	pract	pract	NOUN
dpc-4871	128	7	concept	concept	NOUN
dpc-4871	128	8	.	.	PUNCT
dpc-4871	129	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	129	2	it	it	PRON
dpc-4871	129	3	must	must	AUX
dpc-4871	129	4	be	be	AUX
dpc-4871	129	5	taken	take	VERB
dpc-4871	129	6	into	into	ADP
dpc-4871	129	7	account	account	NOUN
dpc-4871	129	8	that	that	SCONJ
dpc-4871	129	9	the	the	DET
dpc-4871	129	10	general	general	ADJ
dpc-4871	129	11	findings	finding	NOUN
dpc-4871	129	12	are	be	AUX
dpc-4871	129	13	very	very	ADV
dpc-4871	129	14	limited	limited	ADJ
dpc-4871	129	15	.	.	PUNCT
dpc-4871	130	1	conclusions	conclusion	NOUN
dpc-4871	130	2	currently	currently	ADV
dpc-4871	130	3	,	,	PUNCT
dpc-4871	130	4	systemic	systemic	ADJ
dpc-4871	130	5	non	non	ADJ
dpc-4871	130	6	-	-	ADJ
dpc-4871	130	7	biological	biological	ADJ
dpc-4871	130	8	therapy	therapy	NOUN
dpc-4871	130	9	and	and	CCONJ
dpc-4871	130	10	,	,	PUNCT
dpc-4871	130	11	in	in	ADP
dpc-4871	130	12	particular	particular	ADJ
dpc-4871	130	13	,	,	PUNCT
dpc-4871	130	14	conventional	conventional	ADJ
dpc-4871	130	15	therapy	therapy	NOUN
dpc-4871	130	16	remain	remain	VERB
dpc-4871	130	17	the	the	DET
dpc-4871	130	18	therapeutic	therapeutic	ADJ
dpc-4871	130	19	fulcrum	fulcrum	NOUN
dpc-4871	130	20	of	of	ADP
dpc-4871	130	21	pp	pp	PROPN
dpc-4871	130	22	management	management	NOUN
dpc-4871	130	23	.	.	PUNCT
dpc-4871	131	1	our	our	PRON
dpc-4871	131	2	study	study	NOUN
dpc-4871	131	3	shows	show	VERB
dpc-4871	131	4	that	that	SCONJ
dpc-4871	131	5	there	there	PRON
dpc-4871	131	6	are	be	VERB
dpc-4871	131	7	substantial	substantial	ADJ
dpc-4871	131	8	differences	difference	NOUN
dpc-4871	131	9	between	between	ADP
dpc-4871	131	10	ppp	ppp	NOUN
dpc-4871	131	11	and	and	CCONJ
dpc-4871	131	12	gpp+pso	gpp+pso	NOUN
dpc-4871	131	13	.	.	PUNCT
dpc-4871	132	1	even	even	ADV
dpc-4871	132	2	if	if	SCONJ
dpc-4871	132	3	systemic	systemic	ADJ
dpc-4871	132	4	conventional	conventional	ADJ
dpc-4871	132	5	treatment	treatment	NOUN
dpc-4871	132	6	was	be	AUX
dpc-4871	132	7	the	the	DET
dpc-4871	132	8	most	most	ADV
dpc-4871	132	9	represented	represent	VERB
dpc-4871	132	10	in	in	ADP
dpc-4871	132	11	both	both	DET
dpc-4871	132	12	conditions	condition	NOUN
dpc-4871	132	13	,	,	PUNCT
dpc-4871	132	14	it	it	PRON
dpc-4871	132	15	was	be	AUX
dpc-4871	132	16	associated	associate	VERB
dpc-4871	132	17	with	with	ADP
dpc-4871	132	18	a	a	DET
dpc-4871	132	19	good	good	ADJ
dpc-4871	132	20	impact	impact	NOUN
dpc-4871	132	21	on	on	ADP
dpc-4871	132	22	qol	qol	NOUN
dpc-4871	132	23	only	only	ADV
dpc-4871	132	24	in	in	ADP
dpc-4871	132	25	ppp	ppp	NOUN
dpc-4871	132	26	.	.	PUNCT
dpc-4871	133	1	almost	almost	ADV
dpc-4871	133	2	the	the	DET
dpc-4871	133	3	half	half	NOUN
dpc-4871	133	4	of	of	ADP
dpc-4871	133	5	our	our	PRON
dpc-4871	133	6	gpp+pso	gpp+pso	NOUN
dpc-4871	133	7	patients	patient	NOUN
dpc-4871	133	8	reported	report	VERB
dpc-4871	133	9	a	a	DET
dpc-4871	133	10	great	great	ADJ
dpc-4871	133	11	impact	impact	NOUN
dpc-4871	133	12	on	on	ADP
dpc-4871	133	13	qol	qol	NOUN
dpc-4871	133	14	regardless	regardless	ADV
dpc-4871	133	15	of	of	ADP
dpc-4871	133	16	the	the	DET
dpc-4871	133	17	ongoing	ongoing	ADJ
dpc-4871	133	18	treatment	treatment	NOUN
dpc-4871	133	19	,	,	PUNCT
dpc-4871	133	20	and	and	CCONJ
dpc-4871	133	21	only	only	ADV
dpc-4871	133	22	newer	new	ADJ
dpc-4871	133	23	biologic	biologic	ADJ
dpc-4871	133	24	options	option	NOUN
dpc-4871	133	25	,	,	PUNCT
dpc-4871	133	26	like	like	ADP
dpc-4871	133	27	guselkumab	guselkumab	NOUN
dpc-4871	133	28	,	,	PUNCT
dpc-4871	133	29	ixekizumab	ixekizumab	NOUN
dpc-4871	133	30	and	and	CCONJ
dpc-4871	133	31	risankizumab	risankizumab	NOUN
dpc-4871	133	32	were	be	AUX
dpc-4871	133	33	able	able	ADJ
dpc-4871	133	34	to	to	PART
dpc-4871	133	35	somehow	somehow	ADV
dpc-4871	133	36	positively	positively	ADV
dpc-4871	133	37	impact	impact	NOUN
dpc-4871	133	38	on	on	ADP
dpc-4871	133	39	qol	qol	PROPN
dpc-4871	133	40	.	.	PUNCT
dpc-4871	134	1	outcomes	outcome	NOUN
dpc-4871	134	2	coming	come	VERB
dpc-4871	134	3	from	from	ADP
dpc-4871	134	4	qol	qol	PROPN
dpc-4871	134	5	are	be	AUX
dpc-4871	134	6	often	often	ADV
dpc-4871	134	7	signals	signal	NOUN
dpc-4871	134	8	of	of	ADP
dpc-4871	134	9	unsatisfied	unsatisfied	ADJ
dpc-4871	134	10	needs	need	NOUN
dpc-4871	134	11	,	,	PUNCT
dpc-4871	134	12	and	and	CCONJ
dpc-4871	134	13	in	in	ADP
dpc-4871	134	14	this	this	DET
dpc-4871	134	15	study	study	NOUN
dpc-4871	134	16	there	there	ADV
dpc-4871	134	17	arises	arise	VERB
dpc-4871	134	18	the	the	DET
dpc-4871	134	19	need	need	NOUN
dpc-4871	134	20	of	of	ADP
dpc-4871	134	21	specific	specific	ADJ
dpc-4871	134	22	approved	approve	VERB
dpc-4871	134	23	therapies	therapy	NOUN
dpc-4871	134	24	for	for	ADP
dpc-4871	134	25	the	the	DET
dpc-4871	134	26	management	management	NOUN
dpc-4871	134	27	of	of	ADP
dpc-4871	134	28	pp	pp	PROPN
dpc-4871	134	29	.	.	PUNCT
dpc-4871	135	1	references	reference	NOUN
dpc-4871	135	2	1	1	NUM
dpc-4871	135	3	.	.	PUNCT
dpc-4871	135	4	reich	reich	PROPN
dpc-4871	135	5	k	k	PROPN
dpc-4871	135	6	,	,	PUNCT
dpc-4871	135	7	augustin	augustin	PROPN
dpc-4871	135	8	m	m	PROPN
dpc-4871	135	9	,	,	PUNCT
dpc-4871	135	10	gerdes	gerdes	PROPN
dpc-4871	135	11	s	s	PROPN
dpc-4871	135	12	,	,	PUNCT
dpc-4871	135	13	et	et	PROPN
dpc-4871	135	14	al	al	PROPN
dpc-4871	135	15	.	.	PROPN
dpc-4871	136	1	generalized	generalize	VERB
dpc-4871	136	2	pustular	pustular	ADJ
dpc-4871	136	3	psoriasis	psoriasis	NOUN
dpc-4871	136	4	:	:	PUNCT
dpc-4871	136	5	overview	overview	NOUN
dpc-4871	136	6	of	of	ADP
dpc-4871	136	7	the	the	DET
dpc-4871	136	8	status	status	NOUN
dpc-4871	136	9	quo	quo	NOUN
dpc-4871	136	10	and	and	CCONJ
dpc-4871	136	11	results	result	NOUN
dpc-4871	136	12	of	of	ADP
dpc-4871	136	13	a	a	DET
dpc-4871	136	14	panel	panel	NOUN
dpc-4871	136	15	discussion	discussion	NOUN
dpc-4871	136	16	.	.	PUNCT
dpc-4871	137	1	j	j	PROPN
dpc-4871	137	2	dtsch	dtsch	PROPN
dpc-4871	137	3	dermatol	dermatol	NOUN
dpc-4871	137	4	ges	ge	NOUN
dpc-4871	137	5	.	.	PUNCT
dpc-4871	137	6	2022;20:753	2022;20:753	PROPN
dpc-4871	137	7	-	-	SYM
dpc-4871	137	8	771	771	NUM
dpc-4871	137	9	.	.	PUNCT
dpc-4871	138	1	doi	doi	NOUN
dpc-4871	138	2	:	:	PUNCT
dpc-4871	138	3	10.1111	10.1111	NUM
dpc-4871	138	4	/ddg.14764	/ddg.14764	NOUN
dpc-4871	138	5	.	.	PUNCT
dpc-4871	139	1	pmid	pmid	NOUN
dpc-4871	139	2	:	:	PUNCT
dpc-4871	139	3	35674482	35674482	NUM
dpc-4871	139	4	.	.	PUNCT
dpc-4871	140	1	2	2	X
dpc-4871	140	2	.	.	X
dpc-4871	140	3	reisner	reisner	PROPN
dpc-4871	140	4	dv	dv	PROPN
dpc-4871	140	5	,	,	PUNCT
dpc-4871	140	6	johnsson	johnsson	PROPN
dpc-4871	140	7	fd	fd	PROPN
dpc-4871	140	8	,	,	PUNCT
dpc-4871	140	9	kotowsky	kotowsky	ADJ
dpc-4871	140	10	n	n	NOUN
dpc-4871	140	11	,	,	PUNCT
dpc-4871	140	12	brunette	brunette	NOUN
dpc-4871	140	13	s	s	PROPN
dpc-4871	140	14	,	,	PUNCT
dpc-4871	140	15	valdecantos	valdecantos	ADJ
dpc-4871	140	16	w	w	ADP
dpc-4871	140	17	,	,	PUNCT
dpc-4871	140	18	eyerich	eyerich	PROPN
dpc-4871	140	19	k.	k.	PROPN
dpc-4871	140	20	impact	impact	NOUN
dpc-4871	140	21	of	of	ADP
dpc-4871	140	22	generalized	generalized	ADJ
dpc-4871	140	23	pustular	pustular	ADJ
dpc-4871	140	24	psoriasis	psoriasis	NOUN
dpc-4871	140	25	from	from	ADP
dpc-4871	140	26	the	the	DET
dpc-4871	140	27	perspective	perspective	NOUN
dpc-4871	140	28	of	of	ADP
dpc-4871	140	29	people	people	NOUN
dpc-4871	140	30	living	live	VERB
dpc-4871	140	31	with	with	ADP
dpc-4871	140	32	the	the	DET
dpc-4871	140	33	condition	condition	NOUN
dpc-4871	140	34	:	:	PUNCT
dpc-4871	140	35	results	result	NOUN
dpc-4871	140	36	of	of	ADP
dpc-4871	140	37	an	an	DET
dpc-4871	140	38	online	online	ADJ
dpc-4871	140	39	survey	survey	NOUN
dpc-4871	140	40	.	.	PUNCT
dpc-4871	141	1	am	be	AUX
dpc-4871	141	2	j	j	PROPN
dpc-4871	141	3	clin	clin	PROPN
dpc-4871	141	4	dermatol	dermatol	NOUN
dpc-4871	141	5	.	.	PUNCT
dpc-4871	142	1	2022;23(suppl	2022;23(suppl	ADJ
dpc-4871	142	2	1):65	1):65	NUM
dpc-4871	142	3	-	-	SYM
dpc-4871	142	4	71	71	NUM
dpc-4871	142	5	.	.	PUNCT
dpc-4871	143	1	doi	doi	NOUN
dpc-4871	143	2	:	:	PUNCT
dpc-4871	143	3	10.1007	10.1007	NUM
dpc-4871	143	4	/	/	SYM
dpc-4871	143	5	s40257	s40257	NOUN
dpc-4871	143	6	-	-	PUNCT
dpc-4871	143	7	021	021	NUM
dpc-4871	143	8	-	-	PUNCT
dpc-4871	143	9	00663	00663	NUM
dpc-4871	143	10	-	-	PUNCT
dpc-4871	143	11	y.	y.	NOUN
dpc-4871	143	12	3	3	NUM
dpc-4871	143	13	.	.	PUNCT
dpc-4871	144	1	twelves	twelves	PROPN
dpc-4871	144	2	s	s	PROPN
dpc-4871	144	3	,	,	PUNCT
dpc-4871	144	4	mostafa	mostafa	PROPN
dpc-4871	144	5	a	a	PROPN
dpc-4871	144	6	,	,	PUNCT
dpc-4871	144	7	dand	dand	PROPN
dpc-4871	144	8	n	n	CCONJ
dpc-4871	144	9	,	,	PUNCT
dpc-4871	144	10	et	et	PROPN
dpc-4871	144	11	al	al	PROPN
dpc-4871	144	12	.	.	PROPN
dpc-4871	145	1	clinical	clinical	ADJ
dpc-4871	145	2	and	and	CCONJ
dpc-4871	145	3	genetic	genetic	ADJ
dpc-4871	145	4	differences	difference	NOUN
dpc-4871	145	5	between	between	ADP
dpc-4871	145	6	pustular	pustular	ADJ
dpc-4871	145	7	psoriasis	psoriasis	NOUN
dpc-4871	145	8	subtypes	subtype	NOUN
dpc-4871	145	9	.	.	PUNCT
dpc-4871	146	1	j	j	PROPN
dpc-4871	146	2	allergy	allergy	PROPN
dpc-4871	146	3	clin	clin	PROPN
dpc-4871	146	4	immunol	immunol	NOUN
dpc-4871	146	5	.	.	PUNCT
dpc-4871	147	1	2019;143(3):1021	2019;143(3):1021	NUM
dpc-4871	147	2	-	-	SYM
dpc-4871	147	3	1026	1026	NUM
dpc-4871	147	4	.	.	PUNCT
dpc-4871	148	1	doi	doi	NOUN
dpc-4871	148	2	:	:	PUNCT
dpc-4871	148	3	10.1016	10.1016	NUM
dpc-4871	148	4	/	/	SYM
dpc-4871	148	5	j.jaci.2018.06.038	j.jaci.2018.06.038	PROPN
dpc-4871	148	6	.	.	PUNCT
dpc-4871	149	1	4	4	X
dpc-4871	149	2	.	.	X
dpc-4871	149	3	genovese	genovese	NOUN
dpc-4871	149	4	g	g	PROPN
dpc-4871	149	5	,	,	PUNCT
dpc-4871	149	6	moltrasio	moltrasio	PROPN
dpc-4871	149	7	c	c	PROPN
dpc-4871	149	8	,	,	PUNCT
dpc-4871	149	9	cassano	cassano	PROPN
dpc-4871	149	10	n	n	CCONJ
dpc-4871	149	11	,	,	PUNCT
dpc-4871	149	12	maronese	maronese	PROPN
dpc-4871	149	13	ca	ca	NOUN
dpc-4871	149	14	,	,	PUNCT
dpc-4871	149	15	vena	vena	PROPN
dpc-4871	149	16	ga	ga	PROPN
dpc-4871	149	17	,	,	PUNCT
dpc-4871	149	18	marzano	marzano	PROPN
dpc-4871	149	19	av	av	PROPN
dpc-4871	149	20	.	.	PUNCT
dpc-4871	149	21	pustular	pustular	ADJ
dpc-4871	149	22	psoriasis	psoriasis	NOUN
dpc-4871	149	23	:	:	PUNCT
dpc-4871	149	24	from	from	ADP
dpc-4871	149	25	pathophysiology	pathophysiology	NOUN
dpc-4871	149	26	to	to	ADP
dpc-4871	149	27	treatment	treatment	NOUN
dpc-4871	149	28	.	.	PUNCT
dpc-4871	150	1	biomedicines	biomedicine	NOUN
dpc-4871	150	2	.	.	PUNCT
dpc-4871	151	1	2021;9(12):1746	2021;9(12):1746	X
dpc-4871	151	2	.	.	PUNCT
dpc-4871	151	3	doi	doi	NOUN
dpc-4871	151	4	:	:	PUNCT
dpc-4871	151	5	10.3390	10.3390	NUM
dpc-4871	151	6	/biomedicines9121746	/biomedicines9121746	PUNCT
dpc-4871	151	7	.	.	PUNCT
dpc-4871	152	1	5	5	NUM
dpc-4871	152	2	.	.	X
dpc-4871	153	1	zhou	zhou	PROPN
dpc-4871	153	2	j	j	PROPN
dpc-4871	153	3	,	,	PUNCT
dpc-4871	153	4	luo	luo	PROPN
dpc-4871	153	5	q	q	PROPN
dpc-4871	153	6	,	,	PUNCT
dpc-4871	153	7	cheng	cheng	PROPN
dpc-4871	153	8	y	y	PROPN
dpc-4871	153	9	,	,	PUNCT
dpc-4871	153	10	wen	wen	PROPN
dpc-4871	153	11	x	x	PROPN
dpc-4871	153	12	,	,	PUNCT
dpc-4871	153	13	liu	liu	PROPN
dpc-4871	153	14	j.	j.	PROPN
dpc-4871	153	15	an	an	DET
dpc-4871	153	16	update	update	NOUN
dpc-4871	153	17	on	on	ADP
dpc-4871	153	18	genetic	genetic	ADJ
dpc-4871	153	19	basis	basis	NOUN
dpc-4871	153	20	of	of	ADP
dpc-4871	153	21	generalized	generalized	ADJ
dpc-4871	153	22	pustular	pustular	ADJ
dpc-4871	153	23	psoriasis	psoriasis	NOUN
dpc-4871	153	24	(	(	PUNCT
dpc-4871	153	25	review	review	NOUN
dpc-4871	153	26	)	)	PUNCT
dpc-4871	153	27	.	.	PUNCT
dpc-4871	154	1	int	int	PROPN
dpc-4871	154	2	j	j	PROPN
dpc-4871	154	3	mol	mol	ADP
dpc-4871	154	4	med	med	PROPN
dpc-4871	154	5	.	.	PUNCT
dpc-4871	155	1	2021;47(4):118	2021;47(4):118	PROPN
dpc-4871	155	2	.	.	PUNCT
dpc-4871	156	1	doi	doi	NOUN
dpc-4871	156	2	:	:	PUNCT
dpc-4871	156	3	10.3892	10.3892	NUM
dpc-4871	156	4	/	/	SYM
dpc-4871	156	5	ijmm.2021.4951	ijmm.2021.4951	NOUN
dpc-4871	156	6	.	.	PUNCT
dpc-4871	157	1	6	6	NUM
dpc-4871	157	2	.	.	NOUN
dpc-4871	157	3	mössner	mössner	NOUN
dpc-4871	157	4	r	r	NOUN
dpc-4871	157	5	,	,	PUNCT
dpc-4871	157	6	wilsmann	wilsmann	PROPN
dpc-4871	157	7	-	-	PUNCT
dpc-4871	157	8	theis	theis	PROPN
dpc-4871	157	9	d	d	PROPN
dpc-4871	157	10	,	,	PUNCT
dpc-4871	157	11	oji	oji	PROPN
dpc-4871	157	12	v	v	PROPN
dpc-4871	157	13	,	,	PUNCT
dpc-4871	157	14	et	et	PROPN
dpc-4871	157	15	al	al	PROPN
dpc-4871	157	16	.	.	PUNCT
dpc-4871	158	1	the	the	DET
dpc-4871	158	2	genetic	genetic	ADJ
dpc-4871	158	3	basis	basis	NOUN
dpc-4871	158	4	for	for	ADP
dpc-4871	158	5	most	most	ADJ
dpc-4871	158	6	patients	patient	NOUN
dpc-4871	158	7	with	with	ADP
dpc-4871	158	8	pustular	pustular	ADJ
dpc-4871	158	9	skin	skin	NOUN
dpc-4871	158	10	disease	disease	NOUN
dpc-4871	158	11	remains	remain	VERB
dpc-4871	158	12	elusive	elusive	ADJ
dpc-4871	158	13	.	.	PUNCT
dpc-4871	159	1	br	br	X
dpc-4871	159	2	j	j	PROPN
dpc-4871	159	3	dermatol	dermatol	NOUN
dpc-4871	159	4	.	.	PUNCT
dpc-4871	160	1	2018;178(3):740	2018;178(3):740	X
dpc-4871	160	2	-	-	SYM
dpc-4871	160	3	748	748	NUM
dpc-4871	160	4	.	.	PUNCT
dpc-4871	161	1	doi	doi	NOUN
dpc-4871	161	2	:	:	PUNCT
dpc-4871	161	3	10.1111	10.1111	NUM
dpc-4871	161	4	/	/	SYM
dpc-4871	161	5	bjd.15867	bjd.15867	NUM
dpc-4871	161	6	.	.	PUNCT
dpc-4871	162	1	7	7	X
dpc-4871	162	2	.	.	X
dpc-4871	162	3	sugiura	sugiura	PROPN
dpc-4871	162	4	k	k	PROPN
dpc-4871	162	5	,	,	PUNCT
dpc-4871	162	6	muto	muto	PROPN
dpc-4871	162	7	m	m	PROPN
dpc-4871	162	8	,	,	PUNCT
dpc-4871	162	9	akiyama	akiyama	PROPN
dpc-4871	162	10	m.	m.	PROPN
dpc-4871	162	11	card14	card14	PROPN
dpc-4871	162	12	c.526g	c.526g	PROPN
dpc-4871	162	13	>	>	X
dpc-4871	162	14	c	c	PROPN
dpc-4871	162	15	(	(	PUNCT
dpc-4871	162	16	p.	p.	NOUN
dpc-4871	162	17	asp176his	asp176hi	VERB
dpc-4871	162	18	)	)	PUNCT
dpc-4871	162	19	is	be	AUX
dpc-4871	162	20	a	a	DET
dpc-4871	162	21	significant	significant	ADJ
dpc-4871	162	22	risk	risk	NOUN
dpc-4871	162	23	factor	factor	NOUN
dpc-4871	162	24	for	for	ADP
dpc-4871	162	25	generalized	generalized	ADJ
dpc-4871	162	26	pustular	pustular	ADJ
dpc-4871	162	27	psoriasis	psoriasis	NOUN
dpc-4871	162	28	with	with	ADP
dpc-4871	162	29	psoriasis	psoriasis	NOUN
dpc-4871	162	30	vulgaris	vulgaris	NOUN
dpc-4871	162	31	in	in	ADP
dpc-4871	162	32	the	the	DET
dpc-4871	162	33	japanese	japanese	ADJ
dpc-4871	162	34	cohort	cohort	NOUN
dpc-4871	162	35	.	.	PUNCT
dpc-4871	163	1	j	j	PROPN
dpc-4871	163	2	invest	invest	VERB
dpc-4871	163	3	dermatol	dermatol	NOUN
dpc-4871	163	4	.	.	PUNCT
dpc-4871	164	1	2014;134(6):1755	2014;134(6):1755	NUM
dpc-4871	164	2	-	-	SYM
dpc-4871	164	3	1757	1757	NUM
dpc-4871	164	4	.	.	PUNCT
dpc-4871	165	1	doi	doi	NOUN
dpc-4871	165	2	:	:	PUNCT
dpc-4871	165	3	10.1038	10.1038	NUM
dpc-4871	165	4	/	/	SYM
dpc-4871	165	5	jid.2014.46	jid.2014.46	PROPN
dpc-4871	165	6	.	.	PROPN
dpc-4871	165	7	8	8	NUM
dpc-4871	165	8	.	.	PUNCT
dpc-4871	165	9	li	li	PROPN
dpc-4871	166	1	l	l	PROPN
dpc-4871	166	2	,	,	PUNCT
dpc-4871	166	3	you	you	PRON
dpc-4871	166	4	j	j	PROPN
dpc-4871	166	5	,	,	PUNCT
dpc-4871	166	6	fu	fu	PROPN
dpc-4871	166	7	x	x	NOUN
dpc-4871	166	8	,	,	PUNCT
dpc-4871	166	9	et	et	PROPN
dpc-4871	166	10	al	al	PROPN
dpc-4871	166	11	.	.	PUNCT
dpc-4871	167	1	variants	variant	NOUN
dpc-4871	167	2	of	of	ADP
dpc-4871	167	3	card14	card14	NOUN
dpc-4871	167	4	are	be	AUX
dpc-4871	167	5	predisposing	predispose	VERB
dpc-4871	167	6	factors	factor	NOUN
dpc-4871	167	7	for	for	ADP
dpc-4871	167	8	generalized	generalized	ADJ
dpc-4871	167	9	pustular	pustular	ADJ
dpc-4871	167	10	psoriasis	psoriasis	NOUN
dpc-4871	167	11	(	(	PUNCT
dpc-4871	167	12	gpp	gpp	NOUN
dpc-4871	167	13	)	)	PUNCT
dpc-4871	167	14	with	with	ADP
dpc-4871	167	15	psoriasis	psoriasis	NOUN
dpc-4871	167	16	vulgaris	vulgaris	NOUN
dpc-4871	167	17	but	but	CCONJ
dpc-4871	167	18	not	not	PART
dpc-4871	167	19	for	for	ADP
dpc-4871	167	20	gpp	gpp	NOUN
dpc-4871	167	21	alone	alone	ADJ
dpc-4871	167	22	in	in	ADP
dpc-4871	167	23	a	a	DET
dpc-4871	167	24	chinese	chinese	ADJ
dpc-4871	167	25	population	population	NOUN
dpc-4871	167	26	.	.	PUNCT
dpc-4871	168	1	br	br	PROPN
dpc-4871	168	2	j	j	PROPN
dpc-4871	168	3	dermatol	dermatol	NOUN
dpc-4871	168	4	.	.	PUNCT
dpc-4871	169	1	2019;180(2):425	2019;180(2):425	NUM
dpc-4871	169	2	-	-	SYM
dpc-4871	169	3	426	426	NUM
dpc-4871	169	4	.	.	PUNCT
dpc-4871	169	5	doi	doi	NOUN
dpc-4871	169	6	:	:	PUNCT
dpc-4871	169	7	10.1111	10.1111	NUM
dpc-4871	169	8	/	/	SYM
dpc-4871	169	9	bjd.17392	bjd.17392	NOUN
dpc-4871	169	10	.	.	NOUN
dpc-4871	169	11	9	9	NUM
dpc-4871	169	12	.	.	X
dpc-4871	170	1	menter	menter	PROPN
dpc-4871	170	2	a	a	PROPN
dpc-4871	170	3	,	,	PUNCT
dpc-4871	170	4	van	van	PROPN
dpc-4871	170	5	voorhees	voorhees	PROPN
dpc-4871	170	6	as	as	ADP
dpc-4871	170	7	,	,	PUNCT
dpc-4871	170	8	hsu	hsu	PROPN
dpc-4871	170	9	s.	s.	PROPN
dpc-4871	170	10	pustular	pustular	ADJ
dpc-4871	170	11	psoriasis	psoriasis	NOUN
dpc-4871	170	12	:	:	PUNCT
dpc-4871	170	13	a	a	DET
dpc-4871	170	14	narrative	narrative	NOUN
dpc-4871	170	15	review	review	NOUN
dpc-4871	170	16	of	of	ADP
dpc-4871	170	17	recent	recent	ADJ
dpc-4871	170	18	developments	development	NOUN
dpc-4871	170	19	in	in	ADP
dpc-4871	170	20	pathophysiology	pathophysiology	NOUN
dpc-4871	170	21	and	and	CCONJ
dpc-4871	170	22	therapeutic	therapeutic	ADJ
dpc-4871	170	23	options	option	NOUN
dpc-4871	170	24	.	.	PUNCT
dpc-4871	171	1	dermatol	dermatol	NOUN
dpc-4871	171	2	ther	ther	ADV
dpc-4871	171	3	(	(	PUNCT
dpc-4871	171	4	heidelb	heidelb	NOUN
dpc-4871	171	5	)	)	PUNCT
dpc-4871	171	6	.	.	PUNCT
dpc-4871	172	1	2021	2021	NUM
dpc-4871	172	2	;	;	PUNCT
dpc-4871	172	3	11(6):1917	11(6):1917	NUM
dpc-4871	172	4	-	-	SYM
dpc-4871	172	5	1929	1929	NUM
dpc-4871	172	6	.	.	PUNCT
dpc-4871	173	1	doi	doi	NOUN
dpc-4871	173	2	:	:	PUNCT
dpc-4871	173	3	10.1007	10.1007	NUM
dpc-4871	173	4	/	/	SYM
dpc-4871	173	5	s13555	s13555	PROPN
dpc-4871	173	6	-	-	PUNCT
dpc-4871	173	7	021	021	NUM
dpc-4871	173	8	-	-	PUNCT
dpc-4871	173	9	00612	00612	NUM
dpc-4871	173	10	-	-	PUNCT
dpc-4871	173	11	x.	x.	NOUN
dpc-4871	173	12	most	most	ADV
dpc-4871	173	13	used	use	VERB
dpc-4871	173	14	drug	drug	NOUN
dpc-4871	173	15	in	in	ADP
dpc-4871	173	16	both	both	DET
dpc-4871	173	17	subtypes	subtype	NOUN
dpc-4871	173	18	of	of	ADP
dpc-4871	173	19	pp	pp	ADV
dpc-4871	173	20	,	,	PUNCT
dpc-4871	173	21	while	while	SCONJ
dpc-4871	173	22	methotrexate	methotrexate	NOUN
dpc-4871	173	23	appears	appear	VERB
dpc-4871	173	24	to	to	PART
dpc-4871	173	25	be	be	AUX
dpc-4871	173	26	more	more	ADV
dpc-4871	173	27	prerogative	prerogative	NOUN
dpc-4871	173	28	of	of	ADP
dpc-4871	173	29	the	the	DET
dpc-4871	173	30	generalized	generalized	ADJ
dpc-4871	173	31	form	form	NOUN
dpc-4871	173	32	associated	associate	VERB
dpc-4871	173	33	with	with	ADP
dpc-4871	173	34	psoriasis	psoriasis	NOUN
dpc-4871	173	35	[	[	X
dpc-4871	173	36	19	19	NUM
dpc-4871	173	37	]	]	PUNCT
dpc-4871	173	38	.	.	PUNCT
dpc-4871	174	1	on	on	ADP
dpc-4871	174	2	the	the	DET
dpc-4871	174	3	other	other	ADJ
dpc-4871	174	4	hand	hand	NOUN
dpc-4871	174	5	,	,	PUNCT
dpc-4871	174	6	in	in	ADP
dpc-4871	174	7	accordance	accordance	NOUN
dpc-4871	174	8	with	with	ADP
dpc-4871	174	9	what	what	PRON
dpc-4871	174	10	emerges	emerge	VERB
dpc-4871	174	11	from	from	ADP
dpc-4871	174	12	the	the	DET
dpc-4871	174	13	review	review	NOUN
dpc-4871	174	14	of	of	ADP
dpc-4871	174	15	wang	wang	PROPN
dpc-4871	174	16	et	et	PROPN
dpc-4871	174	17	al	al	PROPN
dpc-4871	175	1	[	[	X
dpc-4871	175	2	20	20	NUM
dpc-4871	175	3	]	]	PUNCT
dpc-4871	175	4	,	,	PUNCT
dpc-4871	175	5	among	among	ADP
dpc-4871	175	6	systemic	systemic	ADJ
dpc-4871	175	7	biological	biological	ADJ
dpc-4871	175	8	drugs	drug	NOUN
dpc-4871	175	9	,	,	PUNCT
dpc-4871	175	10	there	there	PRON
dpc-4871	175	11	is	be	VERB
dpc-4871	175	12	still	still	ADV
dpc-4871	175	13	little	little	ADJ
dpc-4871	175	14	experience	experience	NOUN
dpc-4871	175	15	with	with	ADP
dpc-4871	175	16	the	the	DET
dpc-4871	175	17	ppp	ppp	NOUN
dpc-4871	175	18	form	form	NOUN
dpc-4871	175	19	,	,	PUNCT
dpc-4871	175	20	except	except	SCONJ
dpc-4871	175	21	for	for	ADP
dpc-4871	175	22	the	the	DET
dpc-4871	175	23	use	use	NOUN
dpc-4871	175	24	of	of	ADP
dpc-4871	175	25	secukinumab	secukinumab	NOUN
dpc-4871	175	26	[	[	X
dpc-4871	175	27	21	21	NUM
dpc-4871	175	28	]	]	PUNCT
dpc-4871	175	29	.	.	PUNCT
dpc-4871	176	1	indeed	indeed	ADV
dpc-4871	176	2	,	,	PUNCT
dpc-4871	176	3	in	in	ADP
dpc-4871	176	4	the	the	DET
dpc-4871	176	5	gpp	gpp	NOUN
dpc-4871	176	6	subtype	subtype	NOUN
dpc-4871	176	7	,	,	PUNCT
dpc-4871	176	8	there	there	PRON
dpc-4871	176	9	is	be	VERB
dpc-4871	176	10	evidence	evidence	NOUN
dpc-4871	176	11	[	[	X
dpc-4871	176	12	22	22	NUM
dpc-4871	176	13	]	]	PUNCT
dpc-4871	176	14	of	of	ADP
dpc-4871	176	15	favorable	favorable	ADJ
dpc-4871	176	16	outcomes	outcome	NOUN
dpc-4871	176	17	of	of	ADP
dpc-4871	176	18	some	some	DET
dpc-4871	176	19	biologics	biologic	NOUN
dpc-4871	176	20	,	,	PUNCT
dpc-4871	176	21	including	include	VERB
dpc-4871	176	22	adalimumab	adalimumab	NOUN
dpc-4871	176	23	and	and	CCONJ
dpc-4871	176	24	ixekizumab	ixekizumab	NOUN
dpc-4871	176	25	,	,	PUNCT
dpc-4871	176	26	when	when	SCONJ
dpc-4871	176	27	compared	compare	VERB
dpc-4871	176	28	to	to	ADP
dpc-4871	176	29	treatment	treatment	NOUN
dpc-4871	176	30	with	with	ADP
dpc-4871	176	31	traditional	traditional	ADJ
dpc-4871	176	32	drugs	drug	NOUN
dpc-4871	176	33	.	.	PUNCT
dpc-4871	177	1	in	in	ADP
dpc-4871	177	2	line	line	NOUN
dpc-4871	177	3	with	with	ADP
dpc-4871	177	4	our	our	PRON
dpc-4871	177	5	results	result	NOUN
dpc-4871	177	6	,	,	PUNCT
dpc-4871	177	7	schwartz	schwartz	PROPN
dpc-4871	177	8	et	et	PROPN
dpc-4871	177	9	al	al	PROPN
dpc-4871	178	1	[	[	X
dpc-4871	178	2	23	23	NUM
dpc-4871	178	3	]	]	PUNCT
dpc-4871	178	4	confirm	confirm	VERB
dpc-4871	178	5	the	the	DET
dpc-4871	178	6	evidence	evidence	NOUN
dpc-4871	178	7	that	that	PRON
dpc-4871	178	8	acitretin	acitretin	VERB
dpc-4871	178	9	first	first	ADV
dpc-4871	178	10	and	and	CCONJ
dpc-4871	178	11	then	then	ADV
dpc-4871	178	12	methotrexate	methotrexate	VERB
dpc-4871	178	13	were	be	AUX
dpc-4871	178	14	the	the	DET
dpc-4871	178	15	most	most	ADV
dpc-4871	178	16	used	use	VERB
dpc-4871	178	17	drugs	drug	NOUN
dpc-4871	178	18	,	,	PUNCT
dpc-4871	178	19	with	with	ADP
dpc-4871	178	20	a	a	DET
dpc-4871	178	21	significantly	significantly	ADV
dpc-4871	178	22	higher	high	ADJ
dpc-4871	178	23	representation	representation	NOUN
dpc-4871	178	24	in	in	ADP
dpc-4871	178	25	gpp	gpp	NOUN
dpc-4871	178	26	.	.	PUNCT
dpc-4871	179	1	regarding	regard	VERB
dpc-4871	179	2	biologics	biologic	NOUN
dpc-4871	179	3	,	,	PUNCT
dpc-4871	179	4	we	we	PRON
dpc-4871	179	5	have	have	VERB
dpc-4871	179	6	ppp	ppp	NOUN
dpc-4871	179	7	patients	patient	NOUN
dpc-4871	179	8	treated	treat	VERB
dpc-4871	179	9	only	only	ADV
dpc-4871	179	10	with	with	ADP
dpc-4871	179	11	adalimumab	adalimumab	NOUN
dpc-4871	179	12	or	or	CCONJ
dpc-4871	179	13	secukinumab	secukinumab	NOUN
dpc-4871	179	14	,	,	PUNCT
dpc-4871	179	15	whereas	whereas	SCONJ
dpc-4871	179	16	for	for	ADP
dpc-4871	179	17	gpp	gpp	NOUN
dpc-4871	179	18	+	+	CCONJ
dpc-4871	179	19	pso	pso	NOUN
dpc-4871	179	20	patients	patient	NOUN
dpc-4871	179	21	all	all	DET
dpc-4871	179	22	biologics	biologic	NOUN
dpc-4871	179	23	are	be	AUX
dpc-4871	179	24	used	use	VERB
dpc-4871	179	25	,	,	PUNCT
dpc-4871	179	26	even	even	ADV
dpc-4871	179	27	if	if	SCONJ
dpc-4871	179	28	there	there	PRON
dpc-4871	179	29	is	be	VERB
dpc-4871	179	30	a	a	DET
dpc-4871	179	31	significantly	significantly	ADV
dpc-4871	179	32	higher	high	ADJ
dpc-4871	179	33	representation	representation	NOUN
dpc-4871	179	34	for	for	ADP
dpc-4871	179	35	adalimumab	adalimumab	NOUN
dpc-4871	179	36	and	and	CCONJ
dpc-4871	179	37	ixekizumab	ixekizumab	NOUN
dpc-4871	179	38	.	.	PUNCT
dpc-4871	180	1	in	in	ADP
dpc-4871	180	2	this	this	DET
dpc-4871	180	3	study	study	NOUN
dpc-4871	180	4	,	,	PUNCT
dpc-4871	180	5	we	we	PRON
dpc-4871	180	6	documented	document	VERB
dpc-4871	180	7	the	the	DET
dpc-4871	180	8	association	association	NOUN
dpc-4871	180	9	of	of	ADP
dpc-4871	180	10	qol	qol	PROPN
dpc-4871	180	11	with	with	ADP
dpc-4871	180	12	the	the	DET
dpc-4871	180	13	current	current	ADJ
dpc-4871	180	14	systemic	systemic	ADJ
dpc-4871	180	15	treatments	treatment	NOUN
dpc-4871	180	16	in	in	ADP
dpc-4871	180	17	ppp	ppp	PROPN
dpc-4871	180	18	and	and	CCONJ
dpc-4871	180	19	gpp	gpp	NOUN
dpc-4871	180	20	+	+	CCONJ
dpc-4871	180	21	pso	pso	NOUN
dpc-4871	180	22	in	in	ADP
dpc-4871	180	23	order	order	NOUN
dpc-4871	180	24	to	to	PART
dpc-4871	180	25	identify	identify	VERB
dpc-4871	180	26	factors	factor	NOUN
dpc-4871	180	27	that	that	PRON
dpc-4871	180	28	may	may	AUX
dpc-4871	180	29	influence	influence	VERB
dpc-4871	180	30	the	the	DET
dpc-4871	180	31	therapeutic	therapeutic	ADJ
dpc-4871	180	32	decision	decision	NOUN
dpc-4871	180	33	.	.	PUNCT
dpc-4871	181	1	ppp	ppp	NOUN
dpc-4871	181	2	patients	patient	NOUN
dpc-4871	181	3	were	be	AUX
dpc-4871	181	4	more	more	ADV
dpc-4871	181	5	likely	likely	ADJ
dpc-4871	181	6	to	to	PART
dpc-4871	181	7	achieve	achieve	VERB
dpc-4871	181	8	a	a	DET
dpc-4871	181	9	dlqi	dlqi	NOUN
dpc-4871	181	10	<	<	X
dpc-4871	181	11	10	10	NUM
dpc-4871	181	12	with	with	ADP
dpc-4871	181	13	acitretin	acitretin	ADJ
dpc-4871	181	14	treatment	treatment	NOUN
dpc-4871	181	15	,	,	PUNCT
dpc-4871	181	16	whereas	whereas	SCONJ
dpc-4871	181	17	they	they	PRON
dpc-4871	181	18	were	be	AUX
dpc-4871	181	19	less	less	ADV
dpc-4871	181	20	likely	likely	ADJ
dpc-4871	181	21	to	to	PART
dpc-4871	181	22	achieve	achieve	VERB
dpc-4871	181	23	such	such	DET
dpc-4871	181	24	a	a	DET
dpc-4871	181	25	goal	goal	NOUN
dpc-4871	181	26	when	when	SCONJ
dpc-4871	181	27	in	in	ADP
dpc-4871	181	28	treatment	treatment	NOUN
dpc-4871	181	29	with	with	ADP
dpc-4871	181	30	secukinumab	secukinumab	NOUN
dpc-4871	181	31	.	.	PUNCT
dpc-4871	182	1	to	to	PART
dpc-4871	182	2	reinforce	reinforce	VERB
dpc-4871	182	3	this	this	DET
dpc-4871	182	4	data	datum	NOUN
dpc-4871	182	5	,	,	PUNCT
dpc-4871	182	6	mean	mean	VERB
dpc-4871	182	7	treatment	treatment	NOUN
dpc-4871	182	8	duration	duration	NOUN
dpc-4871	182	9	was	be	AUX
dpc-4871	182	10	higher	high	ADJ
dpc-4871	182	11	for	for	ADP
dpc-4871	182	12	acitretin	acitretin	ADJ
dpc-4871	182	13	respect	respect	NOUN
dpc-4871	182	14	to	to	ADP
dpc-4871	182	15	secukinumab	secukinumab	NOUN
dpc-4871	182	16	.	.	PUNCT
dpc-4871	183	1	regarding	regard	VERB
dpc-4871	183	2	gpp	gpp	NOUN
dpc-4871	183	3	+	+	CCONJ
dpc-4871	183	4	pso	pso	NOUN
dpc-4871	183	5	patients	patient	NOUN
dpc-4871	183	6	,	,	PUNCT
dpc-4871	183	7	they	they	PRON
dpc-4871	183	8	were	be	AUX
dpc-4871	183	9	less	less	ADV
dpc-4871	183	10	associated	associate	VERB
dpc-4871	183	11	with	with	ADP
dpc-4871	183	12	dlqi	dlqi	PROPN
dpc-4871	183	13	≥10	≥10	PROPN
dpc-4871	183	14	when	when	SCONJ
dpc-4871	183	15	treated	treat	VERB
dpc-4871	183	16	with	with	ADP
dpc-4871	183	17	guselkumab	guselkumab	NOUN
dpc-4871	183	18	,	,	PUNCT
dpc-4871	183	19	ixekizumab	ixekizumab	NOUN
dpc-4871	183	20	and	and	CCONJ
dpc-4871	183	21	risankizumab	risankizumab	NOUN
dpc-4871	183	22	,	,	PUNCT
dpc-4871	183	23	whereas	whereas	SCONJ
dpc-4871	183	24	they	they	PRON
dpc-4871	183	25	were	be	AUX
dpc-4871	183	26	significantly	significantly	ADV
dpc-4871	183	27	associated	associate	VERB
dpc-4871	183	28	with	with	ADP
dpc-4871	183	29	dlqi	dlqi	PROPN
dpc-4871	183	30	≥10	≥10	PROPN
dpc-4871	183	31	when	when	SCONJ
dpc-4871	183	32	in	in	ADP
dpc-4871	183	33	treatment	treatment	NOUN
dpc-4871	183	34	with	with	ADP
dpc-4871	183	35	certolizumab	certolizumab	NOUN
dpc-4871	183	36	,	,	PUNCT
dpc-4871	183	37	etanercept	etanercept	NOUN
dpc-4871	183	38	,	,	PUNCT
dpc-4871	183	39	secukinumab	secukinumab	NOUN
dpc-4871	183	40	and	and	CCONJ
dpc-4871	183	41	ustekinumab	ustekinumab	NOUN
dpc-4871	183	42	.	.	PUNCT
dpc-4871	184	1	the	the	DET
dpc-4871	184	2	good	good	ADJ
dpc-4871	184	3	outcome	outcome	NOUN
dpc-4871	184	4	related	relate	VERB
dpc-4871	184	5	to	to	ADP
dpc-4871	184	6	acitretin	acitretin	NOUN
dpc-4871	184	7	is	be	AUX
dpc-4871	184	8	already	already	ADV
dpc-4871	184	9	known	know	VERB
dpc-4871	184	10	[	[	PUNCT
dpc-4871	184	11	24	24	NUM
dpc-4871	184	12	]	]	X
dpc-4871	184	13	;	;	PUNCT
dpc-4871	184	14	nonetheless	nonetheless	ADV
dpc-4871	184	15	,	,	PUNCT
dpc-4871	184	16	the	the	DET
dpc-4871	184	17	negative	negative	ADJ
dpc-4871	184	18	association	association	NOUN
dpc-4871	184	19	between	between	ADP
dpc-4871	184	20	secukinumab	secukinumab	NOUN
dpc-4871	184	21	and	and	CCONJ
dpc-4871	184	22	dlqi	dlqi	NOUN
dpc-4871	184	23	<	<	X
dpc-4871	184	24	10	10	NUM
dpc-4871	184	25	was	be	AUX
dpc-4871	184	26	quite	quite	ADV
dpc-4871	184	27	surprising	surprising	ADJ
dpc-4871	184	28	,	,	PUNCT
dpc-4871	184	29	especially	especially	ADV
dpc-4871	184	30	in	in	ADP
dpc-4871	184	31	light	light	NOUN
dpc-4871	184	32	of	of	ADP
dpc-4871	184	33	the	the	DET
dpc-4871	184	34	efficacy	efficacy	NOUN
dpc-4871	184	35	reported	report	VERB
dpc-4871	184	36	[	[	X
dpc-4871	184	37	25	25	NUM
dpc-4871	184	38	]	]	PUNCT
dpc-4871	184	39	.	.	PUNCT
dpc-4871	185	1	it	it	PRON
dpc-4871	185	2	has	have	VERB
dpc-4871	185	3	to	to	PART
dpc-4871	185	4	be	be	AUX
dpc-4871	185	5	taken	take	VERB
dpc-4871	185	6	into	into	ADP
dpc-4871	185	7	account	account	NOUN
dpc-4871	185	8	that	that	SCONJ
dpc-4871	185	9	at	at	ADP
dpc-4871	185	10	the	the	DET
dpc-4871	185	11	time	time	NOUN
dpc-4871	185	12	of	of	ADP
dpc-4871	185	13	the	the	DET
dpc-4871	185	14	analysis	analysis	NOUN
dpc-4871	185	15	,	,	PUNCT
dpc-4871	185	16	secukinumab	secukinumab	NOUN
dpc-4871	185	17	mean	mean	VERB
dpc-4871	185	18	duration	duration	NOUN
dpc-4871	185	19	of	of	ADP
dpc-4871	185	20	treatment	treatment	NOUN
dpc-4871	185	21	was	be	AUX
dpc-4871	185	22	23.8	23.8	NUM
dpc-4871	185	23	months	month	NOUN
dpc-4871	185	24	and	and	CCONJ
dpc-4871	185	25	it	it	PRON
dpc-4871	185	26	has	have	AUX
dpc-4871	185	27	been	be	AUX
dpc-4871	185	28	reported	report	VERB
dpc-4871	185	29	a	a	DET
dpc-4871	185	30	partial	partial	ADJ
dpc-4871	185	31	loss	loss	NOUN
dpc-4871	185	32	of	of	ADP
dpc-4871	185	33	efficacy	efficacy	NOUN
dpc-4871	185	34	for	for	ADP
dpc-4871	185	35	this	this	DET
dpc-4871	185	36	drug	drug	NOUN
dpc-4871	185	37	around	around	ADP
dpc-4871	185	38	this	this	DET
dpc-4871	185	39	interval	interval	NOUN
dpc-4871	185	40	time	time	NOUN
dpc-4871	186	1	[	[	X
dpc-4871	186	2	26	26	NUM
dpc-4871	186	3	]	]	PUNCT
dpc-4871	186	4	.	.	PUNCT
dpc-4871	187	1	an	an	DET
dpc-4871	187	2	interesting	interesting	ADJ
dpc-4871	187	3	result	result	NOUN
dpc-4871	187	4	was	be	AUX
dpc-4871	187	5	that	that	SCONJ
dpc-4871	187	6	acitretin	acitretin	NOUN
dpc-4871	187	7	failed	fail	VERB
dpc-4871	187	8	to	to	PART
dpc-4871	187	9	show	show	VERB
dpc-4871	187	10	neither	neither	CCONJ
dpc-4871	187	11	a	a	DET
dpc-4871	187	12	positive	positive	ADJ
dpc-4871	187	13	association	association	NOUN
dpc-4871	187	14	with	with	ADP
dpc-4871	187	15	dlqi	dlqi	PROPN
dpc-4871	187	16	<	<	X
dpc-4871	187	17	10	10	NUM
dpc-4871	187	18	nor	nor	CCONJ
dpc-4871	187	19	a	a	DET
dpc-4871	187	20	negative	negative	ADJ
dpc-4871	187	21	one	one	NOUN
dpc-4871	187	22	with	with	ADP
dpc-4871	187	23	dlqi	dlqi	PROPN
dpc-4871	187	24	≥10	≥10	PROPN
dpc-4871	187	25	as	as	ADP
dpc-4871	187	26	in	in	ADP
dpc-4871	187	27	ppp	ppp	NOUN
dpc-4871	187	28	.	.	PUNCT
dpc-4871	188	1	this	this	PRON
dpc-4871	188	2	means	mean	VERB
dpc-4871	188	3	that	that	SCONJ
dpc-4871	188	4	acitretin	acitretin	NOUN
dpc-4871	188	5	was	be	AUX
dpc-4871	188	6	not	not	PART
dpc-4871	188	7	able	able	ADJ
dpc-4871	188	8	to	to	PART
dpc-4871	188	9	impact	impact	VERB
dpc-4871	188	10	on	on	ADP
dpc-4871	188	11	qol	qol	NOUN
dpc-4871	188	12	in	in	ADP
dpc-4871	188	13	gpp	gpp	NOUN
dpc-4871	188	14	+	+	CCONJ
dpc-4871	188	15	pso	pso	NOUN
dpc-4871	188	16	patients	patient	NOUN
dpc-4871	188	17	as	as	SCONJ
dpc-4871	188	18	it	it	PRON
dpc-4871	188	19	did	do	VERB
dpc-4871	188	20	in	in	ADP
dpc-4871	188	21	those	those	PRON
dpc-4871	188	22	with	with	ADP
dpc-4871	188	23	the	the	DET
dpc-4871	188	24	ppp	ppp	NOUN
dpc-4871	188	25	subtype	subtype	NOUN
dpc-4871	188	26	.	.	PUNCT
dpc-4871	189	1	in	in	ADP
dpc-4871	189	2	contrast	contrast	NOUN
dpc-4871	189	3	,	,	PUNCT
dpc-4871	189	4	newer	new	ADJ
dpc-4871	189	5	biologic	biologic	NOUN
dpc-4871	189	6	options	option	NOUN
dpc-4871	189	7	,	,	PUNCT
dpc-4871	189	8	like	like	ADP
dpc-4871	189	9	guselkumab	guselkumab	NOUN
dpc-4871	189	10	,	,	PUNCT
dpc-4871	189	11	ixekizumab	ixekizumab	NOUN
dpc-4871	189	12	and	and	CCONJ
dpc-4871	189	13	risankizumab	risankizumab	NOUN
dpc-4871	189	14	,	,	PUNCT
dpc-4871	189	15	were	be	AUX
dpc-4871	189	16	able	able	ADJ
dpc-4871	189	17	to	to	PART
dpc-4871	189	18	show	show	VERB
dpc-4871	189	19	such	such	ADJ
dpc-4871	189	20	negative	negative	ADJ
dpc-4871	189	21	association	association	NOUN
dpc-4871	189	22	with	with	ADP
dpc-4871	189	23	dlqi	dlqi	PROPN
dpc-4871	189	24	≥10	≥10	PROPN
dpc-4871	189	25	highlighting	highlight	VERB
dpc-4871	189	26	their	their	PRON
dpc-4871	189	27	effect	effect	NOUN
dpc-4871	189	28	on	on	ADP
dpc-4871	189	29	qol	qol	PROPN
dpc-4871	189	30	.	.	PUNCT
dpc-4871	190	1	this	this	PRON
dpc-4871	190	2	is	be	AUX
dpc-4871	190	3	in	in	ADP
dpc-4871	190	4	accordance	accordance	NOUN
dpc-4871	190	5	with	with	ADP
dpc-4871	190	6	recent	recent	ADJ
dpc-4871	190	7	works	work	NOUN
dpc-4871	190	8	  	  	SPACE
dpc-4871	191	1	[	[	X
dpc-4871	191	2	22,27	22,27	NOUN
dpc-4871	191	3	]	]	PUNCT
dpc-4871	191	4	reporting	report	VERB
dpc-4871	191	5	that	that	SCONJ
dpc-4871	191	6	biologic	biologic	NOUN
dpc-4871	191	7	treatments	treatment	NOUN
dpc-4871	191	8	show	show	VERB
dpc-4871	191	9	favorable	favorable	ADJ
dpc-4871	191	10	outcomes	outcome	NOUN
dpc-4871	191	11	compared	compare	VERB
dpc-4871	191	12	to	to	ADP
dpc-4871	191	13	other	other	ADJ
dpc-4871	191	14	treatments	treatment	NOUN
dpc-4871	191	15	.	.	PUNCT
dpc-4871	192	1	limitations	limitation	NOUN
dpc-4871	192	2	this	this	DET
dpc-4871	192	3	study	study	NOUN
dpc-4871	192	4	has	have	VERB
dpc-4871	192	5	some	some	DET
dpc-4871	192	6	limitations	limitation	NOUN
dpc-4871	192	7	.	.	PUNCT
dpc-4871	193	1	in	in	ADP
dpc-4871	193	2	particular	particular	ADJ
dpc-4871	193	3	,	,	PUNCT
dpc-4871	193	4	it	it	PRON
dpc-4871	193	5	involves	involve	VERB
dpc-4871	193	6	a	a	DET
dpc-4871	193	7	single	single	ADJ
dpc-4871	193	8	center	center	NOUN
dpc-4871	193	9	and	and	CCONJ
dpc-4871	193	10	it	it	PRON
dpc-4871	193	11	is	be	AUX
dpc-4871	193	12	a	a	DET
dpc-4871	193	13	cross	cross	ADJ
dpc-4871	193	14	-	-	ADJ
dpc-4871	193	15	sectional	sectional	ADJ
dpc-4871	193	16	study	study	NOUN
dpc-4871	193	17	.	.	PUNCT
dpc-4871	194	1	consequently	consequently	ADV
dpc-4871	194	2	,	,	PUNCT
dpc-4871	194	3	original	original	ADJ
dpc-4871	194	4	article	article	NOUN
dpc-4871	194	5	|	|	ADV
dpc-4871	194	6	dermatol	dermatol	ADJ
dpc-4871	194	7	pract	pract	NOUN
dpc-4871	194	8	concept	concept	NOUN
dpc-4871	194	9	.	.	PUNCT
dpc-4871	195	1	2025;15(1):4871	2025;15(1):4871	NUM
dpc-4871	195	2	7	7	NUM
dpc-4871	195	3	19	19	NUM
dpc-4871	195	4	.	.	PUNCT
dpc-4871	196	1	lu	lu	PROPN
dpc-4871	196	2	j	j	PROPN
dpc-4871	196	3	,	,	PUNCT
dpc-4871	196	4	wang	wang	PROPN
dpc-4871	196	5	y	y	PROPN
dpc-4871	196	6	,	,	PUNCT
dpc-4871	196	7	li	li	PROPN
dpc-4871	196	8	y	y	PROPN
dpc-4871	196	9	,	,	PUNCT
dpc-4871	196	10	gong	gong	PROPN
dpc-4871	196	11	y	y	PROPN
dpc-4871	196	12	,	,	PUNCT
dpc-4871	196	13	ding	de	VERB
dpc-4871	196	14	y	y	PROPN
dpc-4871	196	15	,	,	PUNCT
dpc-4871	196	16	shi	shi	PROPN
dpc-4871	196	17	y.	y.	PROPN
dpc-4871	196	18	comparative	comparative	PROPN
dpc-4871	196	19	study	study	NOUN
dpc-4871	196	20	on	on	ADP
dpc-4871	196	21	the	the	DET
dpc-4871	196	22	clinical	clinical	ADJ
dpc-4871	196	23	efficacy	efficacy	NOUN
dpc-4871	196	24	and	and	CCONJ
dpc-4871	196	25	safety	safety	NOUN
dpc-4871	196	26	of	of	ADP
dpc-4871	196	27	acitretin	acitretin	NOUN
dpc-4871	196	28	and	and	CCONJ
dpc-4871	196	29	mtx	mtx	NOUN
dpc-4871	196	30	in	in	ADP
dpc-4871	196	31	the	the	DET
dpc-4871	196	32	treatment	treatment	NOUN
dpc-4871	196	33	of	of	ADP
dpc-4871	196	34	pustular	pustular	ADJ
dpc-4871	196	35	psoriasis	psoriasis	NOUN
dpc-4871	196	36	by	by	ADP
dpc-4871	196	37	tlr7	tlr7	PROPN
dpc-4871	196	38	/	/	SYM
dpc-4871	196	39	myd88	myd88	PROPN
dpc-4871	196	40	/	/	SYM
dpc-4871	196	41	cxcl16	cxcl16	NOUN
dpc-4871	196	42	pathway	pathway	NOUN
dpc-4871	196	43	.	.	PUNCT
dpc-4871	197	1	appl	appl	NOUN
dpc-4871	197	2	bionics	bionic	NOUN
dpc-4871	197	3	biomech	biomech	NOUN
dpc-4871	197	4	.	.	PUNCT
dpc-4871	198	1	2022;2022:9640326	2022;2022:9640326	NOUN
dpc-4871	198	2	.	.	PUNCT
dpc-4871	198	3	published	publish	VERB
dpc-4871	198	4	2022	2022	NUM
dpc-4871	198	5	mar	mar	PROPN
dpc-4871	198	6	18	18	NUM
dpc-4871	198	7	.	.	PUNCT
dpc-4871	199	1	doi	doi	NOUN
dpc-4871	199	2	:	:	PUNCT
dpc-4871	199	3	10.1155/2022/9640326	10.1155/2022/9640326	NUM
dpc-4871	199	4	.	.	NOUN
dpc-4871	199	5	20	20	NUM
dpc-4871	199	6	.	.	PUNCT
dpc-4871	200	1	wang	wang	PROPN
dpc-4871	200	2	wm	wm	PROPN
dpc-4871	200	3	,	,	PUNCT
dpc-4871	200	4	jin	jin	PROPN
dpc-4871	200	5	hz	hz	PROPN
dpc-4871	200	6	.	.	PROPN
dpc-4871	200	7	biologics	biologic	NOUN
dpc-4871	200	8	in	in	ADP
dpc-4871	200	9	the	the	DET
dpc-4871	200	10	treatment	treatment	NOUN
dpc-4871	200	11	of	of	ADP
dpc-4871	200	12	pustular	pustular	ADJ
dpc-4871	200	13	psoriasis	psoriasis	NOUN
dpc-4871	200	14	.	.	PUNCT
dpc-4871	201	1	expert	expert	NOUN
dpc-4871	201	2	opin	opin	NOUN
dpc-4871	201	3	drug	drug	NOUN
dpc-4871	201	4	saf	saf	PROPN
dpc-4871	201	5	.	.	PUNCT
dpc-4871	202	1	2020;19(8):969	2020;19(8):969	NUM
dpc-4871	202	2	-	-	PUNCT
dpc-4871	202	3	980	980	NUM
dpc-4871	202	4	.	.	PUNCT
dpc-4871	203	1	doi	doi	NOUN
dpc-4871	203	2	:	:	PUNCT
dpc-4871	203	3	10.1080/14740338.2020.1785427	10.1080/14740338.2020.1785427	NUM
dpc-4871	203	4	.	.	NOUN
dpc-4871	203	5	21	21	NUM
dpc-4871	203	6	.	.	PUNCT
dpc-4871	204	1	gottlieb	gottlieb	PROPN
dpc-4871	204	2	ab	ab	PROPN
dpc-4871	204	3	,	,	PUNCT
dpc-4871	204	4	kubanov	kubanov	PROPN
dpc-4871	204	5	a	a	PRON
dpc-4871	204	6	,	,	PUNCT
dpc-4871	204	7	van	van	PROPN
dpc-4871	204	8	doorn	doorn	PROPN
dpc-4871	204	9	m	m	PROPN
dpc-4871	204	10	,	,	PUNCT
dpc-4871	204	11	et	et	PROPN
dpc-4871	204	12	al	al	PROPN
dpc-4871	204	13	.	.	PROPN
dpc-4871	204	14	sustained	sustain	VERB
dpc-4871	204	15	efficacy	efficacy	NOUN
dpc-4871	204	16	of	of	ADP
dpc-4871	204	17	secukinumab	secukinumab	NOUN
dpc-4871	204	18	in	in	ADP
dpc-4871	204	19	patients	patient	NOUN
dpc-4871	204	20	with	with	ADP
dpc-4871	204	21	moderate	moderate	ADJ
dpc-4871	204	22	-	-	PUNCT
dpc-4871	204	23	to	to	ADP
dpc-4871	204	24	-	-	PUNCT
dpc-4871	204	25	severe	severe	ADJ
dpc-4871	204	26	palmoplantar	palmoplantar	NOUN
dpc-4871	204	27	psoriasis	psoriasis	NOUN
dpc-4871	204	28	:	:	PUNCT
dpc-4871	204	29	2.5	2.5	NUM
dpc-4871	204	30	-	-	PUNCT
dpc-4871	204	31	year	year	NOUN
dpc-4871	204	32	results	result	NOUN
dpc-4871	204	33	from	from	ADP
dpc-4871	204	34	gesture	gesture	NOUN
dpc-4871	204	35	,	,	PUNCT
dpc-4871	204	36	a	a	DET
dpc-4871	204	37	randomized	randomized	ADJ
dpc-4871	204	38	,	,	PUNCT
dpc-4871	204	39	double	double	ADJ
dpc-4871	204	40	-	-	PUNCT
dpc-4871	204	41	blind	blind	ADJ
dpc-4871	204	42	,	,	PUNCT
dpc-4871	204	43	placebo	placebo	NOUN
dpc-4871	204	44	-	-	PUNCT
dpc-4871	204	45	controlled	control	VERB
dpc-4871	204	46	trial	trial	NOUN
dpc-4871	204	47	.	.	PUNCT
dpc-4871	205	1	br	br	PROPN
dpc-4871	205	2	j	j	PROPN
dpc-4871	205	3	dermatol	dermatol	NOUN
dpc-4871	205	4	.	.	PUNCT
dpc-4871	206	1	2020;182(4):889	2020;182(4):889	NUM
dpc-4871	206	2	-	-	SYM
dpc-4871	206	3	899	899	NUM
dpc-4871	206	4	.	.	PUNCT
dpc-4871	206	5	doi	doi	NOUN
dpc-4871	206	6	:	:	PUNCT
dpc-4871	206	7	10.1111	10.1111	NUM
dpc-4871	206	8	/	/	SYM
dpc-4871	206	9	bjd.18331	bjd.18331	NUM
dpc-4871	206	10	.	.	PUNCT
dpc-4871	207	1	22	22	NUM
dpc-4871	207	2	.	.	PUNCT
dpc-4871	208	1	miyachi	miyachi	PROPN
dpc-4871	208	2	h	h	PROPN
dpc-4871	208	3	,	,	PUNCT
dpc-4871	208	4	konishi	konishi	PROPN
dpc-4871	208	5	t	t	PROPN
dpc-4871	208	6	,	,	PUNCT
dpc-4871	208	7	kumazawa	kumazawa	PROPN
dpc-4871	208	8	r	r	PROPN
dpc-4871	208	9	,	,	PUNCT
dpc-4871	208	10	et	et	PROPN
dpc-4871	208	11	al	al	PROPN
dpc-4871	208	12	.	.	PROPN
dpc-4871	208	13	treatments	treatment	NOUN
dpc-4871	208	14	and	and	CCONJ
dpc-4871	208	15	outcomes	outcome	NOUN
dpc-4871	208	16	of	of	ADP
dpc-4871	208	17	generalized	generalized	ADJ
dpc-4871	208	18	pustular	pustular	ADJ
dpc-4871	208	19	psoriasis	psoriasis	NOUN
dpc-4871	208	20	:	:	PUNCT
dpc-4871	208	21	a	a	DET
dpc-4871	208	22	cohort	cohort	NOUN
dpc-4871	208	23	of	of	ADP
dpc-4871	208	24	1516	1516	NUM
dpc-4871	208	25	patients	patient	NOUN
dpc-4871	208	26	in	in	ADP
dpc-4871	208	27	a	a	DET
dpc-4871	208	28	nationwide	nationwide	ADJ
dpc-4871	208	29	inpatient	inpatient	NOUN
dpc-4871	208	30	database	database	NOUN
dpc-4871	208	31	in	in	ADP
dpc-4871	208	32	japan	japan	PROPN
dpc-4871	208	33	.	.	PUNCT
dpc-4871	209	1	j	j	PROPN
dpc-4871	209	2	am	be	AUX
dpc-4871	209	3	acad	acad	ADJ
dpc-4871	209	4	dermatol	dermatol	NOUN
dpc-4871	209	5	.	.	PUNCT
dpc-4871	210	1	2022;86(6):1266	2022;86(6):1266	PROPN
dpc-4871	210	2	-	-	SYM
dpc-4871	210	3	1274	1274	NUM
dpc-4871	210	4	.	.	PUNCT
dpc-4871	211	1	doi:10.1016	doi:10.1016	PROPN
dpc-4871	211	2	/	/	SYM
dpc-4871	211	3	j.jaad.2021.06.008	j.jaad.2021.06.008	PROPN
dpc-4871	211	4	.	.	PROPN
dpc-4871	212	1	23	23	NUM
dpc-4871	212	2	.	.	PUNCT
dpc-4871	213	1	hoegler	hoegler	PROPN
dpc-4871	213	2	km	km	PROPN
dpc-4871	213	3	,	,	PUNCT
dpc-4871	213	4	john	john	PROPN
dpc-4871	213	5	am	am	PROPN
dpc-4871	213	6	,	,	PUNCT
dpc-4871	213	7	handler	handler	PROPN
dpc-4871	213	8	mz	mz	PROPN
dpc-4871	213	9	,	,	PUNCT
dpc-4871	213	10	schwartz	schwartz	PROPN
dpc-4871	213	11	ra	ra	PROPN
dpc-4871	213	12	.	.	PUNCT
dpc-4871	213	13	generalized	generalize	VERB
dpc-4871	213	14	pustular	pustular	ADJ
dpc-4871	213	15	psoriasis	psoriasis	NOUN
dpc-4871	213	16	:	:	PUNCT
dpc-4871	213	17	a	a	DET
dpc-4871	213	18	review	review	NOUN
dpc-4871	213	19	and	and	CCONJ
dpc-4871	213	20	update	update	VERB
dpc-4871	213	21	on	on	ADP
dpc-4871	213	22	treatment	treatment	NOUN
dpc-4871	213	23	.	.	PUNCT
dpc-4871	214	1	j	j	PROPN
dpc-4871	214	2	eur	eur	PROPN
dpc-4871	214	3	acad	acad	PROPN
dpc-4871	214	4	dermatol	dermatol	NOUN
dpc-4871	214	5	venereol	venereol	NOUN
dpc-4871	214	6	.	.	PUNCT
dpc-4871	215	1	2018;32(10):1645	2018;32(10):1645	NUM
dpc-4871	215	2	-	-	SYM
dpc-4871	215	3	1651	1651	NUM
dpc-4871	215	4	.	.	PUNCT
dpc-4871	216	1	doi	doi	NOUN
dpc-4871	216	2	:	:	PUNCT
dpc-4871	216	3	10.1111	10.1111	NUM
dpc-4871	216	4	/jdv.14949	/jdv.14949	NOUN
dpc-4871	216	5	.	.	PUNCT
dpc-4871	217	1	24	24	NUM
dpc-4871	217	2	.	.	X
dpc-4871	217	3	raposo	raposo	VERB
dpc-4871	217	4	i	i	PRON
dpc-4871	218	1	,	,	PUNCT
dpc-4871	218	2	torres	torre	VERB
dpc-4871	218	3	t.	t.	PROPN
dpc-4871	218	4	palmoplantar	palmoplantar	NOUN
dpc-4871	218	5	psoriasis	psoriasis	NOUN
dpc-4871	218	6	and	and	CCONJ
dpc-4871	218	7	palmoplantar	palmoplantar	NOUN
dpc-4871	218	8	pustulosis	pustulosis	NOUN
dpc-4871	218	9	:	:	PUNCT
dpc-4871	218	10	current	current	ADJ
dpc-4871	218	11	treatment	treatment	NOUN
dpc-4871	218	12	and	and	CCONJ
dpc-4871	218	13	future	future	ADJ
dpc-4871	218	14	prospects	prospect	NOUN
dpc-4871	218	15	.	.	PUNCT
dpc-4871	219	1	am	be	AUX
dpc-4871	219	2	j	j	PROPN
dpc-4871	219	3	clin	clin	PROPN
dpc-4871	219	4	dermatol	dermatol	NOUN
dpc-4871	219	5	.	.	PUNCT
dpc-4871	220	1	2016;17(4):349	2016;17(4):349	PROPN
dpc-4871	220	2	-	-	NUM
dpc-4871	220	3	358	358	NUM
dpc-4871	220	4	.	.	PUNCT
dpc-4871	221	1	doi	doi	NOUN
dpc-4871	221	2	:	:	PUNCT
dpc-4871	221	3	10.1007	10.1007	NUM
dpc-4871	221	4	/	/	SYM
dpc-4871	221	5	s40257	s40257	NOUN
dpc-4871	221	6	-	-	PUNCT
dpc-4871	221	7	016	016	NUM
dpc-4871	221	8	-	-	PUNCT
dpc-4871	221	9	0191	0191	NUM
dpc-4871	221	10	-	-	PUNCT
dpc-4871	221	11	7	7	NUM
dpc-4871	221	12	.	.	NUM
dpc-4871	221	13	25	25	NUM
dpc-4871	221	14	.	.	PUNCT
dpc-4871	222	1	husson	husson	PROPN
dpc-4871	222	2	b	b	PROPN
dpc-4871	222	3	,	,	PUNCT
dpc-4871	222	4	barbe	barbe	PROPN
dpc-4871	222	5	c	c	X
dpc-4871	222	6	,	,	PUNCT
dpc-4871	222	7	hegazy	hegazy	PROPN
dpc-4871	222	8	s	s	PROPN
dpc-4871	222	9	,	,	PUNCT
dpc-4871	222	10	et	et	PROPN
dpc-4871	222	11	al	al	PROPN
dpc-4871	222	12	;	;	PUNCT
dpc-4871	222	13	groupe	groupe	PROPN
dpc-4871	222	14	de	de	X
dpc-4871	222	15	recherche	recherche	X
dpc-4871	222	16	sur	sur	X
dpc-4871	222	17	le	le	X
dpc-4871	222	18	psoriasis	psoriasis	PROPN
dpc-4871	222	19	de	de	X
dpc-4871	222	20	la	la	X
dpc-4871	222	21	société	société	PROPN
dpc-4871	222	22	française	française	PROPN
dpc-4871	222	23	de	de	X
dpc-4871	222	24	dermatologie	dermatologie	PROPN
dpc-4871	222	25	.	.	PUNCT
dpc-4871	223	1	efficacy	efficacy	NOUN
dpc-4871	223	2	and	and	CCONJ
dpc-4871	223	3	safety	safety	NOUN
dpc-4871	223	4	of	of	ADP
dpc-4871	223	5	tnf	tnf	PROPN
dpc-4871	223	6	blockers	blocker	NOUN
dpc-4871	223	7	and	and	CCONJ
dpc-4871	223	8	of	of	ADP
dpc-4871	223	9	ustekinumab	ustekinumab	NOUN
dpc-4871	223	10	in	in	ADP
dpc-4871	223	11	palmoplantar	palmoplantar	NOUN
dpc-4871	223	12	pustulosis	pustulosis	NOUN
dpc-4871	223	13	and	and	CCONJ
dpc-4871	223	14	in	in	ADP
dpc-4871	223	15	acrodermatitis	acrodermatitis	NOUN
dpc-4871	223	16	continua	continua	PROPN
dpc-4871	223	17	of	of	ADP
dpc-4871	223	18	hallopeau	hallopeau	PROPN
dpc-4871	223	19	.	.	PUNCT
dpc-4871	224	1	j	j	PROPN
dpc-4871	224	2	eur	eur	PROPN
dpc-4871	224	3	acad	acad	PROPN
dpc-4871	224	4	dermatol	dermatol	NOUN
dpc-4871	224	5	venereol	venereol	NOUN
dpc-4871	224	6	.	.	PUNCT
dpc-4871	225	1	2020;34(10):2330	2020;34(10):2330	NUM
dpc-4871	225	2	-	-	SYM
dpc-4871	225	3	2338	2338	NUM
dpc-4871	225	4	.	.	PUNCT
dpc-4871	226	1	doi	doi	NOUN
dpc-4871	226	2	:	:	PUNCT
dpc-4871	226	3	10.1111	10.1111	NUM
dpc-4871	226	4	/	/	SYM
dpc-4871	226	5	jdv.16265	jdv.16265	NOUN
dpc-4871	226	6	.	.	PUNCT
dpc-4871	227	1	26	26	NUM
dpc-4871	227	2	.	.	PUNCT
dpc-4871	227	3	ferrières	ferrière	NOUN
dpc-4871	227	4	l	l	PROPN
dpc-4871	227	5	,	,	PUNCT
dpc-4871	227	6	konstantinou	konstantinou	PROPN
dpc-4871	227	7	mp	mp	PROPN
dpc-4871	227	8	,	,	PUNCT
dpc-4871	227	9	bulai	bulai	PROPN
dpc-4871	227	10	livideanu	livideanu	VERB
dpc-4871	227	11	c	c	NOUN
dpc-4871	227	12	,	,	PUNCT
dpc-4871	227	13	et	et	PROPN
dpc-4871	227	14	al	al	PROPN
dpc-4871	227	15	.	.	PROPN
dpc-4871	228	1	longterm	longterm	PROPN
dpc-4871	228	2	continuation	continuation	NOUN
dpc-4871	228	3	with	with	ADP
dpc-4871	228	4	secukinumab	secukinumab	NOUN
dpc-4871	228	5	in	in	ADP
dpc-4871	228	6	psoriasis	psoriasis	NOUN
dpc-4871	228	7	:	:	PUNCT
dpc-4871	228	8	association	association	NOUN
dpc-4871	228	9	with	with	ADP
dpc-4871	228	10	patient	patient	ADJ
dpc-4871	228	11	profile	profile	NOUN
dpc-4871	228	12	and	and	CCONJ
dpc-4871	228	13	initial	initial	ADJ
dpc-4871	228	14	psoriasis	psoriasis	NOUN
dpc-4871	228	15	clearance	clearance	NOUN
dpc-4871	228	16	.	.	PUNCT
dpc-4871	229	1	clin	clin	PROPN
dpc-4871	229	2	exp	exp	NOUN
dpc-4871	229	3	dermatol	dermatol	NOUN
dpc-4871	229	4	.	.	PUNCT
dpc-4871	230	1	2019;44(7):e230	2019;44(7):e230	X
dpc-4871	230	2	-	-	PUNCT
dpc-4871	230	3	e234	e234	PROPN
dpc-4871	230	4	.	.	PUNCT
dpc-4871	230	5	doi	doi	NOUN
dpc-4871	230	6	:	:	PUNCT
dpc-4871	230	7	10.1111	10.1111	NUM
dpc-4871	230	8	/	/	SYM
dpc-4871	230	9	ced.13999	ced.13999	NOUN
dpc-4871	230	10	.	.	PUNCT
dpc-4871	231	1	27	27	NUM
dpc-4871	231	2	.	.	PUNCT
dpc-4871	232	1	kearns	kearns	PROPN
dpc-4871	232	2	dg	dg	PROPN
dpc-4871	232	3	,	,	PUNCT
dpc-4871	232	4	chat	chat	VERB
dpc-4871	232	5	vs	vs	ADP
dpc-4871	232	6	,	,	PUNCT
dpc-4871	232	7	zang	zang	PROPN
dpc-4871	232	8	pd	pd	PROPN
dpc-4871	232	9	,	,	PUNCT
dpc-4871	232	10	han	han	PROPN
dpc-4871	232	11	g	g	PROPN
dpc-4871	232	12	,	,	PUNCT
dpc-4871	232	13	wu	wu	PROPN
dpc-4871	232	14	jj	jj	PROPN
dpc-4871	232	15	.	.	PROPN
dpc-4871	232	16	review	review	PROPN
dpc-4871	232	17	of	of	ADP
dpc-4871	232	18	treatments	treatment	NOUN
dpc-4871	232	19	for	for	ADP
dpc-4871	232	20	generalized	generalized	ADJ
dpc-4871	232	21	pustular	pustular	ADJ
dpc-4871	232	22	psoriasis	psoriasis	NOUN
dpc-4871	232	23	.	.	PUNCT
dpc-4871	233	1	j	j	PROPN
dpc-4871	233	2	dermatolog	dermatolog	PROPN
dpc-4871	233	3	treat	treat	NOUN
dpc-4871	233	4	.	.	PUNCT
dpc-4871	234	1	2021;32(5):492	2021;32(5):492	NUM
dpc-4871	234	2	-	-	PUNCT
dpc-4871	234	3	494	494	NUM
dpc-4871	234	4	.	.	PUNCT
dpc-4871	235	1	doi	doi	NOUN
dpc-4871	235	2	:	:	PUNCT
dpc-4871	235	3	10.1080/09546634.2019.1682502	10.1080/09546634.2019.1682502	NUM
dpc-4871	235	4	.	.	X
dpc-4871	236	1	10	10	NUM
dpc-4871	236	2	.	.	X
dpc-4871	237	1	blair	blair	PROPN
dpc-4871	237	2	ha	ha	PROPN
dpc-4871	237	3	.	.	PROPN
dpc-4871	237	4	spesolimab	spesolimab	PROPN
dpc-4871	237	5	:	:	PUNCT
dpc-4871	237	6	first	first	ADJ
dpc-4871	237	7	approval	approval	NOUN
dpc-4871	237	8	.	.	PUNCT
dpc-4871	238	1	drugs	drug	NOUN
dpc-4871	238	2	.	.	PUNCT
dpc-4871	239	1	2022;82(16	2022;82(16	NUM
dpc-4871	239	2	):	):	PUNCT
dpc-4871	239	3	1681	1681	NUM
dpc-4871	239	4	-	-	SYM
dpc-4871	239	5	1686	1686	NUM
dpc-4871	239	6	.	.	PUNCT
dpc-4871	240	1	doi	doi	NOUN
dpc-4871	240	2	:	:	PUNCT
dpc-4871	240	3	10.1007	10.1007	NUM
dpc-4871	240	4	/	/	SYM
dpc-4871	240	5	s40265	s40265	NOUN
dpc-4871	240	6	-	-	PUNCT
dpc-4871	240	7	022	022	NUM
dpc-4871	240	8	-	-	PUNCT
dpc-4871	240	9	01801	01801	NUM
dpc-4871	240	10	-	-	PUNCT
dpc-4871	240	11	4	4	NUM
dpc-4871	240	12	.	.	NOUN
dpc-4871	240	13	11	11	NUM
dpc-4871	240	14	.	.	PUNCT
dpc-4871	240	15	morita	morita	PROPN
dpc-4871	240	16	a	a	PROPN
dpc-4871	240	17	,	,	PUNCT
dpc-4871	240	18	choon	choon	PROPN
dpc-4871	240	19	se	se	PROPN
dpc-4871	240	20	,	,	PUNCT
dpc-4871	240	21	bachelez	bachelez	PROPN
dpc-4871	240	22	h	h	PROPN
dpc-4871	240	23	,	,	PUNCT
dpc-4871	240	24	et	et	PROPN
dpc-4871	240	25	al	al	PROPN
dpc-4871	240	26	.	.	PUNCT
dpc-4871	241	1	design	design	NOUN
dpc-4871	241	2	of	of	ADP
dpc-4871	241	3	effisayil	effisayil	NOUN
dpc-4871	241	4	™	™	NOUN
dpc-4871	241	5	2	2	NUM
dpc-4871	241	6	:	:	PUNCT
dpc-4871	241	7	a	a	DET
dpc-4871	241	8	randomized	randomized	ADJ
dpc-4871	241	9	,	,	PUNCT
dpc-4871	241	10	double	double	ADJ
dpc-4871	241	11	-	-	PUNCT
dpc-4871	241	12	blind	blind	ADJ
dpc-4871	241	13	,	,	PUNCT
dpc-4871	241	14	placebo	placebo	NOUN
dpc-4871	241	15	-	-	PUNCT
dpc-4871	241	16	controlled	control	VERB
dpc-4871	241	17	study	study	NOUN
dpc-4871	241	18	of	of	ADP
dpc-4871	241	19	spesolimab	spesolimab	NOUN
dpc-4871	241	20	in	in	ADP
dpc-4871	241	21	preventing	prevent	VERB
dpc-4871	241	22	flares	flare	NOUN
dpc-4871	241	23	in	in	ADP
dpc-4871	241	24	patients	patient	NOUN
dpc-4871	241	25	with	with	ADP
dpc-4871	241	26	generalized	generalized	ADJ
dpc-4871	241	27	pustular	pustular	ADJ
dpc-4871	241	28	psoriasis	psoriasis	NOUN
dpc-4871	241	29	.	.	PUNCT
dpc-4871	242	1	dermatol	dermatol	NOUN
dpc-4871	242	2	ther	ther	ADV
dpc-4871	242	3	(	(	PUNCT
dpc-4871	242	4	heidelb	heidelb	NOUN
dpc-4871	242	5	)	)	PUNCT
dpc-4871	242	6	.	.	PUNCT
dpc-4871	243	1	2023;13(2):347	2023;13(2):347	NUM
dpc-4871	243	2	-	-	PUNCT
dpc-4871	243	3	359	359	NUM
dpc-4871	243	4	.	.	PUNCT
dpc-4871	244	1	doi	doi	NOUN
dpc-4871	244	2	:	:	PUNCT
dpc-4871	244	3	10.1007	10.1007	NUM
dpc-4871	244	4	/	/	SYM
dpc-4871	244	5	s13555	s13555	PROPN
dpc-4871	244	6	-	-	PUNCT
dpc-4871	244	7	022	022	NUM
dpc-4871	244	8	-	-	PUNCT
dpc-4871	244	9	00835	00835	NUM
dpc-4871	244	10	-	-	PUNCT
dpc-4871	244	11	6	6	NUM
dpc-4871	244	12	.	.	NOUN
dpc-4871	244	13	12	12	NUM
dpc-4871	244	14	.	.	PUNCT
dpc-4871	245	1	iznardo	iznardo	PROPN
dpc-4871	245	2	h	h	PROPN
dpc-4871	245	3	,	,	PUNCT
dpc-4871	245	4	puig	puig	PROPN
dpc-4871	245	5	l.	l.	PROPN
dpc-4871	245	6	exploring	explore	VERB
dpc-4871	245	7	the	the	DET
dpc-4871	245	8	role	role	NOUN
dpc-4871	245	9	of	of	ADP
dpc-4871	245	10	il-36	il-36	NOUN
dpc-4871	245	11	cytokines	cytokine	NOUN
dpc-4871	245	12	as	as	ADP
dpc-4871	245	13	a	a	DET
dpc-4871	245	14	new	new	ADJ
dpc-4871	245	15	target	target	NOUN
dpc-4871	245	16	in	in	ADP
dpc-4871	245	17	psoriatic	psoriatic	ADJ
dpc-4871	245	18	disease	disease	NOUN
dpc-4871	245	19	.	.	PUNCT
dpc-4871	246	1	int	int	PROPN
dpc-4871	246	2	j	j	PROPN
dpc-4871	246	3	mol	mol	ADP
dpc-4871	246	4	sci	sci	PROPN
dpc-4871	246	5	.	.	PUNCT
dpc-4871	247	1	2021;22(9):4344	2021;22(9):4344	PROPN
dpc-4871	247	2	.	.	PUNCT
dpc-4871	248	1	doi	doi	PROPN
dpc-4871	248	2	:	:	PUNCT
dpc-4871	248	3	10.3390	10.3390	NUM
dpc-4871	248	4	/	/	SYM
dpc-4871	248	5	ijms22094344	ijms22094344	PROPN
dpc-4871	248	6	.	.	PUNCT
dpc-4871	249	1	13	13	NUM
dpc-4871	249	2	.	.	PUNCT
dpc-4871	250	1	khanskaya	khanskaya	PROPN
dpc-4871	250	2	i	i	PRON
dpc-4871	250	3	,	,	PUNCT
dpc-4871	250	4	pinkstaff	pinkstaff	VERB
dpc-4871	250	5	j	j	PROPN
dpc-4871	250	6	,	,	PUNCT
dpc-4871	250	7	marino	marino	PROPN
dpc-4871	250	8	mh	mh	PROPN
dpc-4871	250	9	,	,	PUNCT
dpc-4871	250	10	savall	savall	PROPN
dpc-4871	250	11	t	t	PROPN
dpc-4871	250	12	,	,	PUNCT
dpc-4871	250	13	li	li	PROPN
dpc-4871	250	14	j	j	PROPN
dpc-4871	250	15	,	,	PUNCT
dpc-4871	250	16	londei	londei	NOUN
dpc-4871	250	17	m.	m.	NOUN
dpc-4871	250	18	a	a	DET
dpc-4871	250	19	phase	phase	NOUN
dpc-4871	250	20	1	1	NUM
dpc-4871	250	21	study	study	NOUN
dpc-4871	250	22	of	of	ADP
dpc-4871	250	23	anb019	anb019	PROPN
dpc-4871	250	24	,	,	PUNCT
dpc-4871	250	25	an	an	DET
dpc-4871	250	26	anti	anti	ADJ
dpc-4871	250	27	-	-	ADJ
dpc-4871	250	28	il-36	il-36	ADJ
dpc-4871	250	29	receptor	receptor	NOUN
dpc-4871	250	30	monoclonal	monoclonal	NOUN
dpc-4871	250	31	antibody	antibody	NOUN
dpc-4871	250	32	,	,	PUNCT
dpc-4871	250	33	in	in	ADP
dpc-4871	250	34	healthy	healthy	ADJ
dpc-4871	250	35	volunteers	volunteer	NOUN
dpc-4871	250	36	.	.	PUNCT
dpc-4871	251	1	anaptysbio	anaptysbio	NOUN
dpc-4871	251	2	.	.	PUNCT
dpc-4871	252	1	2018	2018	NUM
dpc-4871	252	2	.	.	PUNCT
dpc-4871	253	1	disponibile	disponibile	PROPN
dpc-4871	253	2	su	su	PROPN
dpc-4871	253	3	:	:	PUNCT
dpc-4871	253	4	https://www2.anaptysbio.com/wp-content/uploads/anb019	https://www2.anaptysbio.com/wp-content/uploads/anb019	NOUN
dpc-4871	253	5	-phase-1	-phase-1	NOUN
dpc-4871	253	6	-	-	PUNCT
dpc-4871	253	7	study	study	NOUN
dpc-4871	253	8	-	-	PUNCT
dpc-4871	253	9	poster	poster	NOUN
dpc-4871	253	10	-	-	PUNCT
dpc-4871	253	11	eaaci-2018.pdf	eaaci-2018.pdf	NOUN
dpc-4871	253	12	.	.	PUNCT
dpc-4871	254	1	14	14	NUM
dpc-4871	254	2	.	.	PUNCT
dpc-4871	255	1	burden	burden	NOUN
dpc-4871	255	2	ad	ad	NOUN
dpc-4871	255	3	,	,	PUNCT
dpc-4871	255	4	choon	choon	PROPN
dpc-4871	255	5	se	se	PROPN
dpc-4871	255	6	,	,	PUNCT
dpc-4871	255	7	gottlieb	gottlieb	PROPN
dpc-4871	255	8	ab	ab	PROPN
dpc-4871	255	9	,	,	PUNCT
dpc-4871	255	10	navarini	navarini	ADJ
dpc-4871	255	11	aa	aa	PROPN
dpc-4871	255	12	,	,	PUNCT
dpc-4871	255	13	warren	warren	PROPN
dpc-4871	255	14	rb	rb	PROPN
dpc-4871	255	15	.	.	PUNCT
dpc-4871	256	1	clinical	clinical	ADJ
dpc-4871	256	2	disease	disease	NOUN
dpc-4871	256	3	measures	measure	NOUN
dpc-4871	256	4	in	in	ADP
dpc-4871	256	5	generalized	generalized	ADJ
dpc-4871	256	6	pustular	pustular	ADJ
dpc-4871	256	7	psoriasis	psoriasis	NOUN
dpc-4871	256	8	.	.	PUNCT
dpc-4871	257	1	am	be	AUX
dpc-4871	257	2	j	j	PROPN
dpc-4871	257	3	clin	clin	PROPN
dpc-4871	257	4	dermatol	dermatol	NOUN
dpc-4871	257	5	.	.	PUNCT
dpc-4871	258	1	2022;23(suppl	2022;23(suppl	PROPN
dpc-4871	258	2	1):39	1):39	NUM
dpc-4871	258	3	-	-	PUNCT
dpc-4871	258	4	50	50	NUM
dpc-4871	258	5	.	.	PUNCT
dpc-4871	259	1	doi	doi	NOUN
dpc-4871	259	2	:	:	PUNCT
dpc-4871	259	3	10.1007	10.1007	NUM
dpc-4871	259	4	/s40257	/s40257	NOUN
dpc-4871	259	5	-	-	PUNCT
dpc-4871	259	6	021	021	NUM
dpc-4871	259	7	-	-	PUNCT
dpc-4871	259	8	00653	00653	NUM
dpc-4871	259	9	-	-	PUNCT
dpc-4871	259	10	0	0	NUM
dpc-4871	259	11	.	.	NOUN
dpc-4871	259	12	15	15	NUM
dpc-4871	259	13	.	.	PUNCT
dpc-4871	260	1	bhushan	bhushan	PROPN
dpc-4871	260	2	m	m	PROPN
dpc-4871	260	3	,	,	PUNCT
dpc-4871	260	4	burden	burden	NOUN
dpc-4871	260	5	ad	ad	NOUN
dpc-4871	260	6	,	,	PUNCT
dpc-4871	260	7	mcelhone	mcelhone	NOUN
dpc-4871	260	8	k	k	NOUN
dpc-4871	260	9	,	,	PUNCT
dpc-4871	260	10	james	james	PROPN
dpc-4871	260	11	r	r	PROPN
dpc-4871	260	12	,	,	PUNCT
dpc-4871	260	13	vanhoutte	vanhoutte	PROPN
dpc-4871	260	14	fp	fp	PROPN
dpc-4871	260	15	,	,	PUNCT
dpc-4871	260	16	griffiths	griffiths	PROPN
dpc-4871	260	17	ce	ce	PROPN
dpc-4871	260	18	.	.	PROPN
dpc-4871	260	19	oral	oral	PROPN
dpc-4871	260	20	liarozole	liarozole	NOUN
dpc-4871	260	21	in	in	ADP
dpc-4871	260	22	the	the	DET
dpc-4871	260	23	treatment	treatment	NOUN
dpc-4871	260	24	of	of	ADP
dpc-4871	260	25	palmoplantar	palmoplantar	NOUN
dpc-4871	260	26	pustular	pustular	ADJ
dpc-4871	260	27	psoriasis	psoriasis	NOUN
dpc-4871	260	28	:	:	PUNCT
dpc-4871	260	29	a	a	DET
dpc-4871	260	30	randomized	randomized	ADJ
dpc-4871	260	31	,	,	PUNCT
dpc-4871	260	32	double	double	ADJ
dpc-4871	260	33	-	-	PUNCT
dpc-4871	260	34	blind	blind	ADJ
dpc-4871	260	35	,	,	PUNCT
dpc-4871	260	36	placebo	placebo	NOUN
dpc-4871	260	37	controlled	control	VERB
dpc-4871	260	38	study	study	NOUN
dpc-4871	260	39	.	.	PUNCT
dpc-4871	261	1	br	br	PROPN
dpc-4871	261	2	j	j	PROPN
dpc-4871	261	3	dermatol	dermatol	NOUN
dpc-4871	261	4	.	.	PUNCT
dpc-4871	262	1	2001;145(3):546	2001;145(3):546	NUM
dpc-4871	262	2	-	-	SYM
dpc-4871	262	3	553	553	NUM
dpc-4871	262	4	.	.	PUNCT
dpc-4871	262	5	doi	doi	NOUN
dpc-4871	262	6	:	:	PUNCT
dpc-4871	262	7	10.1046	10.1046	NUM
dpc-4871	262	8	/	/	SYM
dpc-4871	262	9	j.1365	j.1365	NOUN
dpc-4871	262	10	-	-	PUNCT
dpc-4871	262	11	2133.2001.04411.x	2133.2001.04411.x	NUM
dpc-4871	262	12	.	.	PUNCT
dpc-4871	263	1	16	16	NUM
dpc-4871	263	2	.	.	PUNCT
dpc-4871	264	1	scala	scala	PROPN
dpc-4871	264	2	e	e	PROPN
dpc-4871	264	3	,	,	PUNCT
dpc-4871	264	4	megna	megna	PROPN
dpc-4871	264	5	m	m	PROPN
dpc-4871	264	6	,	,	PUNCT
dpc-4871	264	7	amerio	amerio	ADP
dpc-4871	264	8	p	p	X
dpc-4871	264	9	,	,	PUNCT
dpc-4871	264	10	et	et	PROPN
dpc-4871	264	11	al	al	PROPN
dpc-4871	264	12	.	.	PUNCT
dpc-4871	265	1	patients	patient	NOUN
dpc-4871	265	2	’	'	PUNCT
dpc-4871	265	3	demographic	demographic	ADJ
dpc-4871	265	4	and	and	CCONJ
dpc-4871	265	5	socioeconomic	socioeconomic	ADJ
dpc-4871	265	6	characteristics	characteristic	NOUN
dpc-4871	265	7	influence	influence	VERB
dpc-4871	265	8	the	the	DET
dpc-4871	265	9	therapeutic	therapeutic	ADJ
dpc-4871	265	10	decision	decision	NOUN
dpc-4871	265	11	making	make	VERB
dpc-4871	265	12	process	process	NOUN
dpc-4871	265	13	in	in	ADP
dpc-4871	265	14	psoriasis	psoriasis	NOUN
dpc-4871	265	15	.	.	PUNCT
dpc-4871	266	1	plos	plos	PROPN
dpc-4871	266	2	one	one	NUM
dpc-4871	266	3	.	.	PUNCT
dpc-4871	267	1	2020;15(8):e0237267	2020;15(8):e0237267	X
dpc-4871	267	2	.	.	PUNCT
dpc-4871	267	3	doi	doi	NOUN
dpc-4871	267	4	:	:	PUNCT
dpc-4871	267	5	10.1371	10.1371	NUM
dpc-4871	267	6	/	/	SYM
dpc-4871	267	7	journal.pone.0237267	journal.pone.0237267	PROPN
dpc-4871	267	8	.	.	PROPN
dpc-4871	267	9	17	17	NUM
dpc-4871	267	10	.	.	PUNCT
dpc-4871	268	1	tosukhowong	tosukhowong	PROPN
dpc-4871	268	2	t	t	PROPN
dpc-4871	268	3	,	,	PUNCT
dpc-4871	268	4	kiratikanon	kiratikanon	PROPN
dpc-4871	268	5	s	s	PROPN
dpc-4871	268	6	,	,	PUNCT
dpc-4871	268	7	wonglamsam	wonglamsam	NOUN
dpc-4871	268	8	p	p	NOUN
dpc-4871	268	9	,	,	PUNCT
dpc-4871	268	10	et	et	PROPN
dpc-4871	268	11	al	al	PROPN
dpc-4871	268	12	.	.	PUNCT
dpc-4871	269	1	epidemiology	epidemiology	NOUN
dpc-4871	269	2	and	and	CCONJ
dpc-4871	269	3	clinical	clinical	ADJ
dpc-4871	269	4	features	feature	NOUN
dpc-4871	269	5	of	of	ADP
dpc-4871	269	6	pustular	pustular	ADJ
dpc-4871	269	7	psoriasis	psoriasis	NOUN
dpc-4871	269	8	:	:	PUNCT
dpc-4871	269	9	a	a	DET
dpc-4871	269	10	15	15	NUM
dpc-4871	269	11	-	-	PUNCT
dpc-4871	269	12	year	year	NOUN
dpc-4871	269	13	retrospective	retrospective	ADJ
dpc-4871	269	14	cohort	cohort	NOUN
dpc-4871	269	15	.	.	PUNCT
dpc-4871	270	1	j	j	PROPN
dpc-4871	270	2	dermatol	dermatol	NOUN
dpc-4871	270	3	.	.	PUNCT
dpc-4871	271	1	2021;48(12):1931	2021;48(12):1931	NUM
dpc-4871	271	2	-	-	SYM
dpc-4871	271	3	1935	1935	NUM
dpc-4871	271	4	.	.	PUNCT
dpc-4871	272	1	doi	doi	NOUN
dpc-4871	272	2	:	:	PUNCT
dpc-4871	272	3	10.1111/1346	10.1111/1346	NUM
dpc-4871	272	4	-	-	NOUN
dpc-4871	272	5	8138.16164	8138.16164	NOUN
dpc-4871	272	6	.	.	PUNCT
dpc-4871	273	1	18	18	NUM
dpc-4871	273	2	.	.	PUNCT
dpc-4871	274	1	pfohler	pfohler	PROPN
dpc-4871	274	2	c	c	PROPN
dpc-4871	274	3	,	,	PUNCT
dpc-4871	274	4	muller	muller	PROPN
dpc-4871	274	5	cs	cs	PROPN
dpc-4871	274	6	,	,	PUNCT
dpc-4871	274	7	vogt	vogt	PROPN
dpc-4871	274	8	t.	t.	PROPN
dpc-4871	274	9	psoriasis	psoriasis	NOUN
dpc-4871	274	10	vulgaris	vulgaris	NOUN
dpc-4871	274	11	and	and	CCONJ
dpc-4871	274	12	psoriasis	psoriasis	NOUN
dpc-4871	274	13	pustulosa	pustulosa	NOUN
dpc-4871	274	14	:	:	PUNCT
dpc-4871	274	15	epidemiology	epidemiology	NOUN
dpc-4871	274	16	,	,	PUNCT
dpc-4871	274	17	quality	quality	NOUN
dpc-4871	274	18	of	of	ADP
dpc-4871	274	19	life	life	NOUN
dpc-4871	274	20	,	,	PUNCT
dpc-4871	274	21	comorbidities	comorbiditie	NOUN
dpc-4871	274	22	and	and	CCONJ
dpc-4871	274	23	treatment	treatment	NOUN
dpc-4871	274	24	.	.	PUNCT
dpc-4871	275	1	curr	curr	PROPN
dpc-4871	275	2	rheumatol	rheumatol	PROPN
dpc-4871	275	3	rev	rev	VERB
dpc-4871	275	4	.	.	PUNCT
dpc-4871	276	1	2013;9(1):2	2013;9(1):2	PROPN
dpc-4871	276	2	-	-	PUNCT
dpc-4871	276	3	7	7	NUM
dpc-4871	276	4	.	.	PUNCT
dpc-4871	276	5	doi	doi	NOUN
dpc-4871	276	6	:	:	PUNCT
dpc-4871	276	7	10.2174	10.2174	NUM
dpc-4871	276	8	/1573397111309010002	/1573397111309010002	PUNCT
dpc-4871	276	9	.	.	PUNCT