id	sid	tid	token	lemma	pos
dpc-4876	1	1	dermatology	dermatology	NOUN
dpc-4876	1	2	:	:	PUNCT
dpc-4876	1	3	practical	practical	ADJ
dpc-4876	1	4	and	and	CCONJ
dpc-4876	1	5	conceptual	conceptual	ADJ
dpc-4876	1	6	original	original	ADJ
dpc-4876	1	7	article	article	NOUN
dpc-4876	1	8	|	|	ADV
dpc-4876	1	9	dermatol	dermatol	ADJ
dpc-4876	1	10	pract	pract	NOUN
dpc-4876	1	11	concept	concept	NOUN
dpc-4876	1	12	.	.	PUNCT
dpc-4876	2	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	2	2	1	1	NUM
dpc-4876	2	3	autophagy	autophagy	ADJ
dpc-4876	2	4	and	and	CCONJ
dpc-4876	2	5	premature	premature	ADJ
dpc-4876	2	6	graying	graying	NOUN
dpc-4876	2	7	of	of	ADP
dpc-4876	2	8	hair	hair	NOUN
dpc-4876	2	9	:	:	PUNCT
dpc-4876	2	10	the	the	DET
dpc-4876	2	11	role	role	NOUN
dpc-4876	2	12	of	of	ADP
dpc-4876	2	13	lc3	lc3	NOUN
dpc-4876	2	14	as	as	ADP
dpc-4876	2	15	a	a	DET
dpc-4876	2	16	biomarker	biomarker	NOUN
dpc-4876	2	17	in	in	ADP
dpc-4876	2	18	a	a	DET
dpc-4876	2	19	case	case	NOUN
dpc-4876	2	20	-	-	PUNCT
dpc-4876	2	21	control	control	NOUN
dpc-4876	2	22	study	study	NOUN
dpc-4876	2	23	wafaa	wafaa	PROPN
dpc-4876	2	24	mohamed	mohamed	PROPN
dpc-4876	2	25	abd	abd	PROPN
dpc-4876	2	26	-	-	PROPN
dpc-4876	2	27	elmagid1	elmagid1	PROPN
dpc-4876	2	28	,	,	PUNCT
dpc-4876	2	29	khalda	khalda	PROPN
dpc-4876	2	30	s.	s.	PROPN
dpc-4876	2	31	amr2	amr2	PROPN
dpc-4876	2	32	,	,	PUNCT
dpc-4876	2	33	hoda	hoda	PROPN
dpc-4876	2	34	a.	a.	PROPN
dpc-4876	2	35	ahmed2	ahmed2	PROPN
dpc-4876	2	36	,	,	PUNCT
dpc-4876	2	37	dina	dina	PROPN
dpc-4876	2	38	ali1	ali1	PROPN
dpc-4876	2	39	,	,	PUNCT
dpc-4876	2	40	amr	amr	NOUN
dpc-4876	2	41	abdelhamed1	abdelhamed1	NOUN
dpc-4876	2	42	1	1	NUM
dpc-4876	2	43	dermatology	dermatology	NOUN
dpc-4876	2	44	,	,	PUNCT
dpc-4876	2	45	venereology	venereology	NOUN
dpc-4876	2	46	and	and	CCONJ
dpc-4876	2	47	andrology	andrology	PROPN
dpc-4876	2	48	department	department	NOUN
dpc-4876	2	49	,	,	PUNCT
dpc-4876	2	50	faculty	faculty	NOUN
dpc-4876	2	51	of	of	ADP
dpc-4876	2	52	medicine	medicine	NOUN
dpc-4876	2	53	,	,	PUNCT
dpc-4876	2	54	sohag	sohag	NOUN
dpc-4876	2	55	university	university	NOUN
dpc-4876	2	56	,	,	PUNCT
dpc-4876	2	57	sohag	sohag	NOUN
dpc-4876	2	58	,	,	PUNCT
dpc-4876	2	59	egypt	egypt	PROPN
dpc-4876	2	60	2	2	NUM
dpc-4876	2	61	medical	medical	ADJ
dpc-4876	2	62	molecular	molecular	ADJ
dpc-4876	2	63	genetics	genetic	NOUN
dpc-4876	2	64	department	department	NOUN
dpc-4876	2	65	,	,	PUNCT
dpc-4876	2	66	human	human	ADJ
dpc-4876	2	67	genetics	genetics	PROPN
dpc-4876	2	68	&	&	CCONJ
dpc-4876	2	69	genome	genome	NOUN
dpc-4876	2	70	research	research	NOUN
dpc-4876	2	71	division	division	NOUN
dpc-4876	2	72	(	(	PUNCT
dpc-4876	2	73	hggr	hggr	PROPN
dpc-4876	2	74	)	)	PUNCT
dpc-4876	2	75	,	,	PUNCT
dpc-4876	2	76	national	national	ADJ
dpc-4876	2	77	research	research	NOUN
dpc-4876	2	78	centre	centre	PROPN
dpc-4876	2	79	(	(	PUNCT
dpc-4876	2	80	nrc	nrc	PROPN
dpc-4876	2	81	)	)	PUNCT
dpc-4876	2	82	,	,	PUNCT
dpc-4876	2	83	egypt	egypt	PROPN
dpc-4876	2	84	key	key	PROPN
dpc-4876	2	85	words	word	NOUN
dpc-4876	2	86	:	:	PUNCT
dpc-4876	2	87	premature	premature	ADJ
dpc-4876	2	88	graying	graying	NOUN
dpc-4876	2	89	of	of	ADP
dpc-4876	2	90	hair	hair	NOUN
dpc-4876	2	91	,	,	PUNCT
dpc-4876	2	92	autophagy	autophagy	NOUN
dpc-4876	2	93	,	,	PUNCT
dpc-4876	2	94	lc3	lc3	NOUN
dpc-4876	2	95	,	,	PUNCT
dpc-4876	2	96	biomarker	biomarker	NOUN
dpc-4876	2	97	,	,	PUNCT
dpc-4876	2	98	pigmentary	pigmentary	ADJ
dpc-4876	2	99	disorders	disorder	NOUN
dpc-4876	2	100	citation	citation	NOUN
dpc-4876	2	101	:	:	PUNCT
dpc-4876	2	102	abd	abd	PROPN
dpc-4876	2	103	-	-	PUNCT
dpc-4876	2	104	elmagid	elmagid	PROPN
dpc-4876	2	105	w	w	PROPN
dpc-4876	2	106	,	,	PUNCT
dpc-4876	2	107	amr	amr	PROPN
dpc-4876	2	108	ks	ks	PROPN
dpc-4876	2	109	,	,	PUNCT
dpc-4876	2	110	ahmed	ahme	VERB
dpc-4876	2	111	ha	ha	PROPN
dpc-4876	2	112	,	,	PUNCT
dpc-4876	2	113	ali	ali	PROPN
dpc-4876	2	114	d	d	PROPN
dpc-4876	2	115	,	,	PUNCT
dpc-4876	2	116	abdelhamed	abdelhame	VERB
dpc-4876	2	117	a.	a.	NOUN
dpc-4876	2	118	autophagy	autophagy	NOUN
dpc-4876	2	119	and	and	CCONJ
dpc-4876	2	120	premature	premature	ADJ
dpc-4876	2	121	graying	graying	NOUN
dpc-4876	2	122	of	of	ADP
dpc-4876	2	123	hair	hair	NOUN
dpc-4876	2	124	:	:	PUNCT
dpc-4876	2	125	the	the	DET
dpc-4876	2	126	role	role	NOUN
dpc-4876	2	127	of	of	ADP
dpc-4876	2	128	lc3	lc3	NOUN
dpc-4876	2	129	as	as	ADP
dpc-4876	2	130	a	a	DET
dpc-4876	2	131	biomarker	biomarker	NOUN
dpc-4876	2	132	in	in	ADP
dpc-4876	2	133	a	a	DET
dpc-4876	2	134	case	case	NOUN
dpc-4876	2	135	-	-	PUNCT
dpc-4876	2	136	control	control	NOUN
dpc-4876	2	137	study	study	NOUN
dpc-4876	2	138	.	.	PUNCT
dpc-4876	3	1	dermatol	dermatol	NOUN
dpc-4876	3	2	pract	pract	PROPN
dpc-4876	3	3	concept	concept	NOUN
dpc-4876	3	4	.	.	PUNCT
dpc-4876	4	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	4	2	.	.	PUNCT
dpc-4876	5	1	doi	doi	NOUN
dpc-4876	5	2	:	:	PUNCT
dpc-4876	5	3	https://doi.org/10.5826/dpc.1502a4876	https://doi.org/10.5826/dpc.1502a4876	NOUN
dpc-4876	5	4	accepted	accept	VERB
dpc-4876	5	5	:	:	PUNCT
dpc-4876	5	6	december	december	PROPN
dpc-4876	5	7	18	18	NUM
dpc-4876	5	8	,	,	PUNCT
dpc-4876	5	9	2024	2024	NUM
dpc-4876	5	10	;	;	PUNCT
dpc-4876	5	11	published	publish	VERB
dpc-4876	5	12	:	:	PUNCT
dpc-4876	6	1	april	april	PROPN
dpc-4876	6	2	2025	2025	NUM
dpc-4876	6	3	copyright	copyright	NOUN
dpc-4876	6	4	:	:	PUNCT
dpc-4876	7	1	©	©	PROPN
dpc-4876	7	2	2025	2025	NUM
dpc-4876	7	3	abd	abd	PROPN
dpc-4876	7	4	-	-	PUNCT
dpc-4876	7	5	elmagid	elmagid	PROPN
dpc-4876	7	6	et	et	PROPN
dpc-4876	7	7	al	al	PROPN
dpc-4876	7	8	.	.	PUNCT
dpc-4876	8	1	this	this	PRON
dpc-4876	8	2	is	be	AUX
dpc-4876	8	3	an	an	DET
dpc-4876	8	4	open	open	ADJ
dpc-4876	8	5	-	-	PUNCT
dpc-4876	8	6	access	access	NOUN
dpc-4876	8	7	article	article	NOUN
dpc-4876	8	8	distributed	distribute	VERB
dpc-4876	8	9	under	under	ADP
dpc-4876	8	10	the	the	DET
dpc-4876	8	11	terms	term	NOUN
dpc-4876	8	12	of	of	ADP
dpc-4876	8	13	the	the	DET
dpc-4876	8	14	creative	creative	ADJ
dpc-4876	8	15	commons	common	NOUN
dpc-4876	8	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-4876	8	17	license	license	NOUN
dpc-4876	8	18	(	(	PUNCT
dpc-4876	8	19	by	by	ADP
dpc-4876	8	20	-	-	PUNCT
dpc-4876	8	21	nc-4.0	nc-4.0	NOUN
dpc-4876	8	22	)	)	PUNCT
dpc-4876	8	23	,	,	PUNCT
dpc-4876	8	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-4876	8	25	,	,	PUNCT
dpc-4876	8	26	which	which	PRON
dpc-4876	8	27	permits	permit	VERB
dpc-4876	8	28	unrestricted	unrestricted	ADJ
dpc-4876	8	29	noncommercial	noncommercial	ADJ
dpc-4876	8	30	use	use	NOUN
dpc-4876	8	31	,	,	PUNCT
dpc-4876	8	32	distribution	distribution	NOUN
dpc-4876	8	33	,	,	PUNCT
dpc-4876	8	34	and	and	CCONJ
dpc-4876	8	35	reproduction	reproduction	NOUN
dpc-4876	8	36	in	in	ADP
dpc-4876	8	37	any	any	DET
dpc-4876	8	38	medium	medium	NOUN
dpc-4876	8	39	,	,	PUNCT
dpc-4876	8	40	provided	provide	VERB
dpc-4876	8	41	the	the	DET
dpc-4876	8	42	original	original	ADJ
dpc-4876	8	43	authors	author	NOUN
dpc-4876	8	44	and	and	CCONJ
dpc-4876	8	45	source	source	NOUN
dpc-4876	8	46	are	be	AUX
dpc-4876	8	47	credited	credit	VERB
dpc-4876	8	48	.	.	PUNCT
dpc-4876	9	1	funding	funding	NOUN
dpc-4876	9	2	:	:	PUNCT
dpc-4876	9	3	none	none	NOUN
dpc-4876	9	4	.	.	PUNCT
dpc-4876	10	1	competing	compete	VERB
dpc-4876	10	2	interests	interest	NOUN
dpc-4876	10	3	:	:	PUNCT
dpc-4876	10	4	none	none	NOUN
dpc-4876	10	5	.	.	PUNCT
dpc-4876	11	1	authorship	authorship	NOUN
dpc-4876	11	2	:	:	PUNCT
dpc-4876	11	3	all	all	DET
dpc-4876	11	4	authors	author	NOUN
dpc-4876	11	5	have	have	AUX
dpc-4876	11	6	read	read	VERB
dpc-4876	11	7	and	and	CCONJ
dpc-4876	11	8	approved	approve	VERB
dpc-4876	11	9	the	the	DET
dpc-4876	11	10	final	final	ADJ
dpc-4876	11	11	manuscript	manuscript	NOUN
dpc-4876	11	12	.	.	PUNCT
dpc-4876	12	1	conceptualization	conceptualization	NOUN
dpc-4876	12	2	,	,	PUNCT
dpc-4876	12	3	wma	wma	PROPN
dpc-4876	12	4	,	,	PUNCT
dpc-4876	12	5	ksa	ksa	PROPN
dpc-4876	12	6	,	,	PUNCT
dpc-4876	12	7	haa	haa	PROPN
dpc-4876	12	8	,	,	PUNCT
dpc-4876	12	9	da	da	PROPN
dpc-4876	12	10	,	,	PUNCT
dpc-4876	12	11	aa	aa	INTJ
dpc-4876	12	12	;	;	PUNCT
dpc-4876	12	13	methodology	methodology	PROPN
dpc-4876	12	14	,	,	PUNCT
dpc-4876	12	15	wma	wma	PROPN
dpc-4876	12	16	,	,	PUNCT
dpc-4876	12	17	ksa	ksa	PROPN
dpc-4876	12	18	,	,	PUNCT
dpc-4876	12	19	haa	haa	PROPN
dpc-4876	12	20	,	,	PUNCT
dpc-4876	12	21	da	da	PROPN
dpc-4876	12	22	,	,	PUNCT
dpc-4876	12	23	aa	aa	INTJ
dpc-4876	12	24	;	;	PUNCT
dpc-4876	12	25	investigation	investigation	NOUN
dpc-4876	12	26	,	,	PUNCT
dpc-4876	12	27	ksa	ksa	PROPN
dpc-4876	12	28	,	,	PUNCT
dpc-4876	12	29	haa	haa	PROPN
dpc-4876	12	30	,	,	PUNCT
dpc-4876	12	31	da	da	PROPN
dpc-4876	12	32	;	;	PUNCT
dpc-4876	12	33	writing	write	VERB
dpc-4876	12	34	–	–	PUNCT
dpc-4876	12	35	original	original	ADJ
dpc-4876	12	36	draft	draft	NOUN
dpc-4876	12	37	,	,	PUNCT
dpc-4876	12	38	haa	haa	PROPN
dpc-4876	12	39	,	,	PUNCT
dpc-4876	12	40	da	da	PROPN
dpc-4876	12	41	,	,	PUNCT
dpc-4876	12	42	aa	aa	INTJ
dpc-4876	12	43	;	;	PUNCT
dpc-4876	12	44	writing	write	VERB
dpc-4876	12	45	–	–	PUNCT
dpc-4876	12	46	review	review	NOUN
dpc-4876	12	47	&	&	CCONJ
dpc-4876	12	48	editing	editing	PROPN
dpc-4876	12	49	,	,	PUNCT
dpc-4876	12	50	wma	wma	PROPN
dpc-4876	12	51	,	,	PUNCT
dpc-4876	12	52	ksa	ksa	PROPN
dpc-4876	12	53	;	;	PUNCT
dpc-4876	12	54	supervision	supervision	PROPN
dpc-4876	12	55	,	,	PUNCT
dpc-4876	12	56	wma	wma	PROPN
dpc-4876	12	57	,	,	PUNCT
dpc-4876	12	58	ksa	ksa	PROPN
dpc-4876	12	59	,	,	PUNCT
dpc-4876	12	60	haa	haa	PROPN
dpc-4876	12	61	,	,	PUNCT
dpc-4876	12	62	aa	aa	INTJ
dpc-4876	12	63	.	.	PUNCT
dpc-4876	13	1	corresponding	correspond	VERB
dpc-4876	13	2	author	author	NOUN
dpc-4876	13	3	:	:	PUNCT
dpc-4876	13	4	amr	amr	PROPN
dpc-4876	13	5	abdelhamed	abdelhamed	NOUN
dpc-4876	13	6	,	,	PUNCT
dpc-4876	13	7	md	md	PROPN
dpc-4876	13	8	.	.	PROPN
dpc-4876	13	9	assistant	assistant	PROPN
dpc-4876	13	10	professor	professor	NOUN
dpc-4876	13	11	of	of	ADP
dpc-4876	13	12	dermatology	dermatology	NOUN
dpc-4876	13	13	,	,	PUNCT
dpc-4876	13	14	venereology	venereology	NOUN
dpc-4876	13	15	,	,	PUNCT
dpc-4876	13	16	and	and	CCONJ
dpc-4876	13	17	andrology	andrology	NOUN
dpc-4876	13	18	.	.	PUNCT
dpc-4876	14	1	department	department	NOUN
dpc-4876	14	2	of	of	ADP
dpc-4876	14	3	dermatology	dermatology	NOUN
dpc-4876	14	4	,	,	PUNCT
dpc-4876	14	5	venereology	venereology	NOUN
dpc-4876	14	6	,	,	PUNCT
dpc-4876	14	7	and	and	CCONJ
dpc-4876	14	8	andrology	andrology	NOUN
dpc-4876	14	9	,	,	PUNCT
dpc-4876	14	10	faculty	faculty	NOUN
dpc-4876	14	11	of	of	ADP
dpc-4876	14	12	medicine	medicine	NOUN
dpc-4876	14	13	,	,	PUNCT
dpc-4876	14	14	sohag	sohag	NOUN
dpc-4876	14	15	university	university	NOUN
dpc-4876	14	16	,	,	PUNCT
dpc-4876	14	17	sohag	sohag	NOUN
dpc-4876	14	18	,	,	PUNCT
dpc-4876	14	19	82524	82524	NUM
dpc-4876	14	20	,	,	PUNCT
dpc-4876	14	21	egypt	egypt	PROPN
dpc-4876	14	22	.	.	PUNCT
dpc-4876	15	1	orcid	orcid	PROPN
dpc-4876	16	1	i	i	PRON
dpc-4876	16	2	d	d	NOUN
dpc-4876	16	3	:	:	PUNCT
dpc-4876	16	4	0000	0000	NUM
dpc-4876	16	5	-	-	PUNCT
dpc-4876	16	6	0002	0002	NUM
dpc-4876	16	7	-	-	PUNCT
dpc-4876	16	8	17002964	17002964	NUM
dpc-4876	16	9	.	.	PUNCT
dpc-4876	17	1	e	e	X
dpc-4876	17	2	-	-	NOUN
dpc-4876	17	3	mail	mail	NOUN
dpc-4876	17	4	:	:	PUNCT
dpc-4876	17	5	amr_abdelhamed@med.sohag.edu.eg	amr_abdelhamed@med.sohag.edu.eg	NOUN
dpc-4876	17	6	introduction	introduction	NOUN
dpc-4876	17	7	:	:	PUNCT
dpc-4876	17	8	premature	premature	ADJ
dpc-4876	17	9	graying	graying	NOUN
dpc-4876	17	10	of	of	ADP
dpc-4876	17	11	hair	hair	NOUN
dpc-4876	17	12	(	(	PUNCT
dpc-4876	17	13	pgh	pgh	PROPN
dpc-4876	17	14	)	)	PUNCT
dpc-4876	17	15	is	be	AUX
dpc-4876	17	16	a	a	DET
dpc-4876	17	17	common	common	ADJ
dpc-4876	17	18	disorder	disorder	NOUN
dpc-4876	17	19	with	with	ADP
dpc-4876	17	20	a	a	DET
dpc-4876	17	21	multifactorial	multifactorial	ADJ
dpc-4876	17	22	etiology	etiology	NOUN
dpc-4876	17	23	.	.	PUNCT
dpc-4876	18	1	autophagy	autophagy	NOUN
dpc-4876	18	2	,	,	PUNCT
dpc-4876	18	3	which	which	PRON
dpc-4876	18	4	is	be	AUX
dpc-4876	18	5	self	self	NOUN
dpc-4876	18	6	-	-	PUNCT
dpc-4876	18	7	cellular	cellular	ADJ
dpc-4876	18	8	digestion	digestion	NOUN
dpc-4876	18	9	,	,	PUNCT
dpc-4876	18	10	has	have	AUX
dpc-4876	18	11	been	be	AUX
dpc-4876	18	12	linked	link	VERB
dpc-4876	18	13	to	to	ADP
dpc-4876	18	14	melanin	melanin	NOUN
dpc-4876	18	15	pigment	pigment	NOUN
dpc-4876	18	16	formation	formation	NOUN
dpc-4876	18	17	;	;	PUNCT
dpc-4876	18	18	however	however	ADV
dpc-4876	18	19	,	,	PUNCT
dpc-4876	18	20	the	the	DET
dpc-4876	18	21	role	role	NOUN
dpc-4876	18	22	of	of	ADP
dpc-4876	18	23	autophagy	autophagy	NOUN
dpc-4876	18	24	in	in	ADP
dpc-4876	18	25	pgh	pgh	PROPN
dpc-4876	18	26	has	have	AUX
dpc-4876	18	27	not	not	PART
dpc-4876	18	28	been	be	AUX
dpc-4876	18	29	investigated	investigate	VERB
dpc-4876	18	30	well	well	ADV
dpc-4876	18	31	.	.	PUNCT
dpc-4876	19	1	objectives	objective	NOUN
dpc-4876	19	2	:	:	PUNCT
dpc-4876	19	3	the	the	DET
dpc-4876	19	4	study	study	NOUN
dpc-4876	19	5	aimed	aim	VERB
dpc-4876	19	6	to	to	PART
dpc-4876	19	7	evaluate	evaluate	VERB
dpc-4876	19	8	the	the	DET
dpc-4876	19	9	relationship	relationship	NOUN
dpc-4876	19	10	between	between	ADP
dpc-4876	19	11	pgh	pgh	PROPN
dpc-4876	19	12	and	and	CCONJ
dpc-4876	19	13	autophagy	autophagy	VERB
dpc-4876	19	14	by	by	ADP
dpc-4876	19	15	measuring	measure	VERB
dpc-4876	19	16	gene	gene	NOUN
dpc-4876	19	17	expression	expression	NOUN
dpc-4876	19	18	and	and	CCONJ
dpc-4876	19	19	serum	serum	NOUN
dpc-4876	19	20	microtubule	microtubule	NOUN
dpc-4876	19	21	-	-	PUNCT
dpc-4876	19	22	associated	associate	VERB
dpc-4876	19	23	protein	protein	NOUN
dpc-4876	19	24	light	light	NOUN
dpc-4876	19	25	chain	chain	NOUN
dpc-4876	19	26	3	3	NUM
dpc-4876	19	27	(	(	PUNCT
dpc-4876	19	28	lc3	lc3	NOUN
dpc-4876	19	29	)	)	PUNCT
dpc-4876	19	30	concentration	concentration	NOUN
dpc-4876	19	31	.	.	PUNCT
dpc-4876	20	1	methods	method	NOUN
dpc-4876	20	2	:	:	PUNCT
dpc-4876	20	3	a	a	DET
dpc-4876	20	4	case	case	NOUN
dpc-4876	20	5	-	-	PUNCT
dpc-4876	20	6	control	control	NOUN
dpc-4876	20	7	study	study	NOUN
dpc-4876	20	8	was	be	AUX
dpc-4876	20	9	conducted	conduct	VERB
dpc-4876	20	10	on	on	ADP
dpc-4876	20	11	39	39	NUM
dpc-4876	20	12	pgh	pgh	NOUN
dpc-4876	20	13	patients	patient	NOUN
dpc-4876	20	14	and	and	CCONJ
dpc-4876	20	15	21	21	NUM
dpc-4876	20	16	controls	control	NOUN
dpc-4876	20	17	.	.	PUNCT
dpc-4876	21	1	patients	patient	NOUN
dpc-4876	21	2	clinically	clinically	ADV
dpc-4876	21	3	diagnosed	diagnose	VERB
dpc-4876	21	4	with	with	ADP
dpc-4876	21	5	pgh	pgh	PROPN
dpc-4876	21	6	and	and	CCONJ
dpc-4876	21	7	aged	aged	ADJ
dpc-4876	21	8	<	<	X
dpc-4876	21	9	30	30	NUM
dpc-4876	21	10	years	year	NOUN
dpc-4876	21	11	were	be	AUX
dpc-4876	21	12	included	include	VERB
dpc-4876	21	13	in	in	ADP
dpc-4876	21	14	the	the	DET
dpc-4876	21	15	study	study	NOUN
dpc-4876	21	16	.	.	PUNCT
dpc-4876	22	1	blood	blood	NOUN
dpc-4876	22	2	samples	sample	NOUN
dpc-4876	22	3	were	be	AUX
dpc-4876	22	4	taken	take	VERB
dpc-4876	22	5	to	to	PART
dpc-4876	22	6	detect	detect	VERB
dpc-4876	22	7	lc3b	lc3b	NOUN
dpc-4876	22	8	protein	protein	NOUN
dpc-4876	22	9	by	by	ADP
dpc-4876	22	10	elisa	elisa	NOUN
dpc-4876	22	11	in	in	ADP
dpc-4876	22	12	the	the	DET
dpc-4876	22	13	serum	serum	NOUN
dpc-4876	22	14	of	of	ADP
dpc-4876	22	15	both	both	DET
dpc-4876	22	16	groups	group	NOUN
dpc-4876	22	17	.	.	PUNCT
dpc-4876	23	1	white	white	ADJ
dpc-4876	23	2	hairs	hair	NOUN
dpc-4876	23	3	from	from	ADP
dpc-4876	23	4	both	both	DET
dpc-4876	23	5	groups	group	NOUN
dpc-4876	23	6	were	be	AUX
dpc-4876	23	7	collected	collect	VERB
dpc-4876	23	8	to	to	PART
dpc-4876	23	9	detect	detect	VERB
dpc-4876	23	10	lc3b	lc3b	NOUN
dpc-4876	23	11	gene	gene	NOUN
dpc-4876	23	12	expression	expression	NOUN
dpc-4876	23	13	by	by	ADP
dpc-4876	23	14	pcr	pcr	PROPN
dpc-4876	23	15	.	.	PUNCT
dpc-4876	24	1	results	result	NOUN
dpc-4876	24	2	:	:	PUNCT
dpc-4876	24	3	there	there	PRON
dpc-4876	24	4	was	be	VERB
dpc-4876	24	5	a	a	DET
dpc-4876	24	6	statistically	statistically	ADV
dpc-4876	24	7	significant	significant	ADJ
dpc-4876	24	8	difference	difference	NOUN
dpc-4876	24	9	between	between	ADP
dpc-4876	24	10	the	the	DET
dpc-4876	24	11	two	two	NUM
dpc-4876	24	12	groups	group	NOUN
dpc-4876	24	13	as	as	SCONJ
dpc-4876	24	14	regards	regard	VERB
dpc-4876	24	15	expression	expression	NOUN
dpc-4876	24	16	levels	level	NOUN
dpc-4876	24	17	of	of	ADP
dpc-4876	24	18	the	the	DET
dpc-4876	24	19	lc3	lc3	NOUN
dpc-4876	24	20	gene	gene	NOUN
dpc-4876	24	21	by	by	ADP
dpc-4876	24	22	pcr	pcr	PROPN
dpc-4876	24	23	(	(	PUNCT
dpc-4876	24	24	p<0.001	p<0.001	PROPN
dpc-4876	24	25	)	)	PUNCT
dpc-4876	24	26	,	,	PUNCT
dpc-4876	24	27	with	with	ADP
dpc-4876	24	28	the	the	DET
dpc-4876	24	29	mean	mean	NOUN
dpc-4876	24	30	in	in	ADP
dpc-4876	24	31	the	the	DET
dpc-4876	24	32	control	control	NOUN
dpc-4876	24	33	group	group	NOUN
dpc-4876	24	34	(	(	PUNCT
dpc-4876	24	35	0.71±	0.71±	NOUN
dpc-4876	24	36	0.3	0.3	NUM
dpc-4876	24	37	)	)	PUNCT
dpc-4876	24	38	lower	low	ADJ
dpc-4876	24	39	than	than	ADP
dpc-4876	24	40	in	in	ADP
dpc-4876	24	41	the	the	DET
dpc-4876	24	42	pgh	pgh	PROPN
dpc-4876	24	43	group	group	NOUN
dpc-4876	24	44	(	(	PUNCT
dpc-4876	24	45	5.1	5.1	NUM
dpc-4876	24	46	±	±	NUM
dpc-4876	24	47	1.4	1.4	NUM
dpc-4876	24	48	)	)	PUNCT
dpc-4876	24	49	.	.	PUNCT
dpc-4876	25	1	also	also	ADV
dpc-4876	25	2	,	,	PUNCT
dpc-4876	25	3	there	there	PRON
dpc-4876	25	4	was	be	VERB
dpc-4876	25	5	a	a	DET
dpc-4876	25	6	positive	positive	ADJ
dpc-4876	25	7	significant	significant	ADJ
dpc-4876	25	8	correlation	correlation	NOUN
dpc-4876	25	9	between	between	ADP
dpc-4876	25	10	lc3	lc3	NOUN
dpc-4876	25	11	concentration	concentration	NOUN
dpc-4876	25	12	and	and	CCONJ
dpc-4876	25	13	lc3	lc3	NOUN
dpc-4876	25	14	gene	gene	NOUN
dpc-4876	25	15	expression	expression	NOUN
dpc-4876	25	16	in	in	ADP
dpc-4876	25	17	control	control	NOUN
dpc-4876	25	18	(	(	PUNCT
dpc-4876	25	19	r=0.867	r=0.867	X
dpc-4876	25	20	,	,	PUNCT
dpc-4876	25	21	p	p	X
dpc-4876	25	22	<	<	X
dpc-4876	25	23	0.001	0.001	NUM
dpc-4876	25	24	)	)	PUNCT
dpc-4876	25	25	and	and	CCONJ
dpc-4876	25	26	in	in	ADP
dpc-4876	25	27	pgh	pgh	PROPN
dpc-4876	25	28	patients	patient	NOUN
dpc-4876	25	29	(	(	PUNCT
dpc-4876	25	30	r=0.954	r=0.954	NOUN
dpc-4876	25	31	,	,	PUNCT
dpc-4876	25	32	p≤0.001	p≤0.001	PROPN
dpc-4876	25	33	)	)	PUNCT
dpc-4876	25	34	.	.	PUNCT
dpc-4876	26	1	multivariate	multivariate	NOUN
dpc-4876	26	2	logistic	logistic	ADJ
dpc-4876	26	3	regression	regression	NOUN
dpc-4876	26	4	analysis	analysis	NOUN
dpc-4876	26	5	for	for	ADP
dpc-4876	26	6	pgh	pgh	NOUN
dpc-4876	26	7	predictors	predictor	NOUN
dpc-4876	26	8	using	use	VERB
dpc-4876	26	9	age	age	NOUN
dpc-4876	26	10	,	,	PUNCT
dpc-4876	26	11	sex	sex	NOUN
dpc-4876	26	12	(	(	PUNCT
dpc-4876	26	13	female	female	NOUN
dpc-4876	26	14	)	)	PUNCT
dpc-4876	26	15	,	,	PUNCT
dpc-4876	26	16	hemoglobin	hemoglobin	NOUN
dpc-4876	26	17	level	level	NOUN
dpc-4876	26	18	,	,	PUNCT
dpc-4876	26	19	lc3	lc3	NOUN
dpc-4876	26	20	concentration	concentration	NOUN
dpc-4876	26	21	,	,	PUNCT
dpc-4876	26	22	and	and	CCONJ
dpc-4876	26	23	lc3	lc3	NOUN
dpc-4876	26	24	gene	gene	NOUN
dpc-4876	26	25	expression	expression	NOUN
dpc-4876	26	26	revealed	reveal	VERB
dpc-4876	26	27	that	that	SCONJ
dpc-4876	26	28	the	the	DET
dpc-4876	26	29	only	only	ADJ
dpc-4876	26	30	predictor	predictor	NOUN
dpc-4876	26	31	of	of	ADP
dpc-4876	26	32	pgh	pgh	PROPN
dpc-4876	26	33	was	be	AUX
dpc-4876	26	34	lc3	lc3	NOUN
dpc-4876	26	35	gene	gene	NOUN
dpc-4876	26	36	expression	expression	NOUN
dpc-4876	26	37	.	.	PUNCT
dpc-4876	27	1	conclusions	conclusion	NOUN
dpc-4876	27	2	:	:	PUNCT
dpc-4876	27	3	premature	premature	ADJ
dpc-4876	27	4	graying	graying	NOUN
dpc-4876	27	5	of	of	ADP
dpc-4876	27	6	hair	hair	NOUN
dpc-4876	27	7	may	may	AUX
dpc-4876	27	8	have	have	VERB
dpc-4876	27	9	a	a	DET
dpc-4876	27	10	link	link	NOUN
dpc-4876	27	11	with	with	ADP
dpc-4876	27	12	autophagy	autophagy	NOUN
dpc-4876	27	13	.	.	PUNCT
dpc-4876	28	1	lc3	lc3	NOUN
dpc-4876	28	2	gene	gene	NOUN
dpc-4876	28	3	expression	expression	NOUN
dpc-4876	28	4	was	be	AUX
dpc-4876	28	5	increased	increase	VERB
dpc-4876	28	6	in	in	ADP
dpc-4876	28	7	pgh	pgh	PROPN
dpc-4876	28	8	patients	patient	NOUN
dpc-4876	28	9	as	as	SCONJ
dpc-4876	28	10	compared	compare	VERB
dpc-4876	28	11	to	to	ADP
dpc-4876	28	12	the	the	DET
dpc-4876	28	13	control	control	NOUN
dpc-4876	28	14	.	.	PUNCT
dpc-4876	29	1	lc3	lc3	NOUN
dpc-4876	29	2	gene	gene	NOUN
dpc-4876	29	3	expression	expression	NOUN
dpc-4876	29	4	may	may	AUX
dpc-4876	29	5	be	be	AUX
dpc-4876	29	6	an	an	DET
dpc-4876	29	7	independent	independent	ADJ
dpc-4876	29	8	predictor	predictor	NOUN
dpc-4876	29	9	of	of	ADP
dpc-4876	29	10	pgh	pgh	PROPN
dpc-4876	29	11	development	development	PROPN
dpc-4876	29	12	.	.	PUNCT
dpc-4876	30	1	autophagy	autophagy	ADJ
dpc-4876	30	2	modulation	modulation	NOUN
dpc-4876	30	3	may	may	AUX
dpc-4876	30	4	be	be	AUX
dpc-4876	30	5	a	a	DET
dpc-4876	30	6	therapeutic	therapeutic	ADJ
dpc-4876	30	7	target	target	NOUN
dpc-4876	30	8	for	for	ADP
dpc-4876	30	9	pgh	pgh	PROPN
dpc-4876	30	10	.	.	PUNCT
dpc-4876	31	1	abstract	abstract	ADJ
dpc-4876	31	2	2	2	NUM
dpc-4876	31	3	original	original	ADJ
dpc-4876	31	4	article	article	NOUN
dpc-4876	31	5	|	|	ADV
dpc-4876	31	6	dermatol	dermatol	ADJ
dpc-4876	31	7	pract	pract	NOUN
dpc-4876	31	8	concept	concept	NOUN
dpc-4876	31	9	.	.	PUNCT
dpc-4876	32	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	32	2	introduction	introduction	NOUN
dpc-4876	32	3	hair	hair	NOUN
dpc-4876	32	4	graying	graying	NOUN
dpc-4876	32	5	(	(	PUNCT
dpc-4876	32	6	canities	canitie	NOUN
dpc-4876	32	7	)	)	PUNCT
dpc-4876	32	8	is	be	AUX
dpc-4876	32	9	a	a	DET
dpc-4876	32	10	common	common	ADJ
dpc-4876	32	11	age	age	NOUN
dpc-4876	32	12	-	-	PUNCT
dpc-4876	32	13	related	relate	VERB
dpc-4876	32	14	physiological	physiological	ADJ
dpc-4876	32	15	change	change	NOUN
dpc-4876	32	16	.	.	PUNCT
dpc-4876	33	1	on	on	ADP
dpc-4876	33	2	average	average	ADJ
dpc-4876	33	3	,	,	PUNCT
dpc-4876	33	4	hair	hair	NOUN
dpc-4876	33	5	graying	graying	NOUN
dpc-4876	33	6	starts	start	VERB
dpc-4876	33	7	in	in	ADP
dpc-4876	33	8	caucasians	caucasian	NOUN
dpc-4876	33	9	in	in	ADP
dpc-4876	33	10	their	their	PRON
dpc-4876	33	11	mid-30s	mid-30	NOUN
dpc-4876	33	12	,	,	PUNCT
dpc-4876	33	13	asians	asian	NOUN
dpc-4876	33	14	in	in	ADP
dpc-4876	33	15	their	their	PRON
dpc-4876	33	16	late	late	ADJ
dpc-4876	33	17	30s	30	NOUN
dpc-4876	33	18	,	,	PUNCT
dpc-4876	33	19	and	and	CCONJ
dpc-4876	33	20	africans	africans	PROPN
dpc-4876	33	21	in	in	ADP
dpc-4876	33	22	their	their	PRON
dpc-4876	33	23	mid40	mid40	NOUN
dpc-4876	34	1	[	[	X
dpc-4876	34	2	1	1	NUM
dpc-4876	34	3	]	]	PUNCT
dpc-4876	34	4	.	.	PUNCT
dpc-4876	35	1	the	the	DET
dpc-4876	35	2	prevalence	prevalence	NOUN
dpc-4876	35	3	of	of	ADP
dpc-4876	35	4	hair	hair	NOUN
dpc-4876	35	5	graying	gray	VERB
dpc-4876	35	6	varies	vary	VERB
dpc-4876	35	7	among	among	ADP
dpc-4876	35	8	different	different	ADJ
dpc-4876	35	9	races	race	NOUN
dpc-4876	35	10	.	.	PUNCT
dpc-4876	36	1	a	a	DET
dpc-4876	36	2	study	study	NOUN
dpc-4876	36	3	has	have	AUX
dpc-4876	36	4	reported	report	VERB
dpc-4876	36	5	that	that	SCONJ
dpc-4876	36	6	half	half	NOUN
dpc-4876	36	7	of	of	ADP
dpc-4876	36	8	the	the	DET
dpc-4876	36	9	hair	hair	NOUN
dpc-4876	36	10	turns	turn	VERB
dpc-4876	36	11	gray	gray	ADJ
dpc-4876	36	12	by	by	ADP
dpc-4876	36	13	the	the	DET
dpc-4876	36	14	age	age	NOUN
dpc-4876	36	15	of	of	ADP
dpc-4876	36	16	50	50	NUM
dpc-4876	36	17	in	in	ADP
dpc-4876	36	18	6–23	6–23	PROPN
dpc-4876	36	19	%	%	NOUN
dpc-4876	36	20	of	of	ADP
dpc-4876	36	21	people	people	NOUN
dpc-4876	37	1	[	[	X
dpc-4876	37	2	2	2	NUM
dpc-4876	37	3	]	]	PUNCT
dpc-4876	37	4	.	.	PUNCT
dpc-4876	38	1	both	both	DET
dpc-4876	38	2	sexes	sex	NOUN
dpc-4876	38	3	are	be	AUX
dpc-4876	38	4	equally	equally	ADV
dpc-4876	38	5	affected	affect	VERB
dpc-4876	38	6	[	[	X
dpc-4876	38	7	3	3	NUM
dpc-4876	38	8	]	]	PUNCT
dpc-4876	38	9	.	.	PUNCT
dpc-4876	39	1	the	the	DET
dpc-4876	39	2	term	term	NOUN
dpc-4876	39	3	premature	premature	ADJ
dpc-4876	39	4	graying	graying	NOUN
dpc-4876	39	5	of	of	ADP
dpc-4876	39	6	hair	hair	NOUN
dpc-4876	39	7	(	(	PUNCT
dpc-4876	39	8	pgh	pgh	PROPN
dpc-4876	39	9	)	)	PUNCT
dpc-4876	39	10	is	be	AUX
dpc-4876	39	11	used	use	VERB
dpc-4876	39	12	when	when	SCONJ
dpc-4876	39	13	graying	gray	VERB
dpc-4876	39	14	occurs	occur	VERB
dpc-4876	39	15	before	before	ADP
dpc-4876	39	16	the	the	DET
dpc-4876	39	17	age	age	NOUN
dpc-4876	39	18	of	of	ADP
dpc-4876	39	19	20	20	NUM
dpc-4876	39	20	in	in	ADP
dpc-4876	39	21	europeans	europeans	PROPN
dpc-4876	39	22	,	,	PUNCT
dpc-4876	39	23	25	25	NUM
dpc-4876	39	24	in	in	ADP
dpc-4876	39	25	asians	asians	PROPN
dpc-4876	39	26	,	,	PUNCT
dpc-4876	39	27	and	and	CCONJ
dpc-4876	39	28	30	30	NUM
dpc-4876	39	29	in	in	ADP
dpc-4876	39	30	africans	africans	PROPN
dpc-4876	39	31	[	[	X
dpc-4876	39	32	4	4	NUM
dpc-4876	39	33	,	,	PUNCT
dpc-4876	39	34	5	5	NUM
dpc-4876	39	35	]	]	PUNCT
dpc-4876	39	36	.	.	PUNCT
dpc-4876	40	1	premature	premature	ADJ
dpc-4876	40	2	graying	graying	NOUN
dpc-4876	40	3	of	of	ADP
dpc-4876	40	4	hair	hair	NOUN
dpc-4876	40	5	has	have	VERB
dpc-4876	40	6	a	a	DET
dpc-4876	40	7	multifactorial	multifactorial	ADJ
dpc-4876	40	8	etiology	etiology	NOUN
dpc-4876	40	9	,	,	PUNCT
dpc-4876	40	10	with	with	ADP
dpc-4876	40	11	an	an	DET
dpc-4876	40	12	autosomal	autosomal	ADJ
dpc-4876	40	13	dominant	dominant	ADJ
dpc-4876	40	14	pattern	pattern	NOUN
dpc-4876	40	15	of	of	ADP
dpc-4876	40	16	inheritance	inheritance	NOUN
dpc-4876	40	17	[	[	X
dpc-4876	40	18	5	5	NUM
dpc-4876	40	19	]	]	PUNCT
dpc-4876	40	20	,	,	PUNCT
dpc-4876	40	21	with	with	ADP
dpc-4876	40	22	various	various	ADJ
dpc-4876	40	23	environmental	environmental	ADJ
dpc-4876	40	24	factors	factor	NOUN
dpc-4876	40	25	,	,	PUNCT
dpc-4876	40	26	including	include	VERB
dpc-4876	40	27	psychological	psychological	ADJ
dpc-4876	40	28	stress	stress	NOUN
dpc-4876	40	29	,	,	PUNCT
dpc-4876	40	30	smoking	smoking	NOUN
dpc-4876	40	31	,	,	PUNCT
dpc-4876	40	32	drugs	drug	NOUN
dpc-4876	40	33	,	,	PUNCT
dpc-4876	40	34	ultraviolet	ultraviolet	ADJ
dpc-4876	40	35	light	light	NOUN
dpc-4876	40	36	,	,	PUNCT
dpc-4876	40	37	and	and	CCONJ
dpc-4876	40	38	nutritional	nutritional	ADJ
dpc-4876	40	39	deficiency	deficiency	NOUN
dpc-4876	40	40	[	[	X
dpc-4876	40	41	4	4	NUM
dpc-4876	40	42	,	,	PUNCT
dpc-4876	40	43	6	6	NUM
dpc-4876	40	44	]	]	PUNCT
dpc-4876	40	45	.	.	PUNCT
dpc-4876	41	1	it	it	PRON
dpc-4876	41	2	also	also	ADV
dpc-4876	41	3	may	may	AUX
dpc-4876	41	4	be	be	AUX
dpc-4876	41	5	associated	associate	VERB
dpc-4876	41	6	with	with	ADP
dpc-4876	41	7	various	various	ADJ
dpc-4876	41	8	autoimmune	autoimmune	ADJ
dpc-4876	41	9	and	and	CCONJ
dpc-4876	41	10	genetic	genetic	ADJ
dpc-4876	41	11	disorders	disorder	NOUN
dpc-4876	41	12	[	[	X
dpc-4876	41	13	3	3	NUM
dpc-4876	41	14	]	]	PUNCT
dpc-4876	41	15	.	.	PUNCT
dpc-4876	42	1	the	the	DET
dpc-4876	42	2	strongest	strong	ADJ
dpc-4876	42	3	associations	association	NOUN
dpc-4876	42	4	have	have	AUX
dpc-4876	42	5	been	be	AUX
dpc-4876	42	6	detected	detect	VERB
dpc-4876	42	7	between	between	ADP
dpc-4876	42	8	personal	personal	ADJ
dpc-4876	42	9	history	history	NOUN
dpc-4876	42	10	and	and	CCONJ
dpc-4876	42	11	family	family	NOUN
dpc-4876	42	12	history	history	NOUN
dpc-4876	42	13	of	of	ADP
dpc-4876	42	14	pgh	pgh	PROPN
dpc-4876	42	15	[	[	X
dpc-4876	42	16	7	7	NUM
dpc-4876	42	17	]	]	PUNCT
dpc-4876	42	18	.	.	PUNCT
dpc-4876	43	1	several	several	ADJ
dpc-4876	43	2	genes	gene	NOUN
dpc-4876	43	3	have	have	AUX
dpc-4876	43	4	been	be	AUX
dpc-4876	43	5	linked	link	VERB
dpc-4876	43	6	to	to	ADP
dpc-4876	43	7	the	the	DET
dpc-4876	43	8	development	development	NOUN
dpc-4876	43	9	of	of	ADP
dpc-4876	43	10	pgh	pgh	PROPN
dpc-4876	43	11	,	,	PUNCT
dpc-4876	43	12	including	include	VERB
dpc-4876	43	13	the	the	DET
dpc-4876	43	14	interferon	interferon	ADJ
dpc-4876	43	15	regulatory	regulatory	ADJ
dpc-4876	43	16	factor	factor	NOUN
dpc-4876	43	17	4	4	NUM
dpc-4876	43	18	gene	gene	NOUN
dpc-4876	43	19	(	(	PUNCT
dpc-4876	43	20	irf4	irf4	PROPN
dpc-4876	43	21	)	)	PUNCT
dpc-4876	43	22	,	,	PUNCT
dpc-4876	43	23	which	which	PRON
dpc-4876	43	24	has	have	VERB
dpc-4876	43	25	a	a	DET
dpc-4876	43	26	role	role	NOUN
dpc-4876	43	27	in	in	ADP
dpc-4876	43	28	melanin	melanin	NOUN
dpc-4876	43	29	production	production	NOUN
dpc-4876	43	30	and	and	CCONJ
dpc-4876	43	31	storage	storage	NOUN
dpc-4876	43	32	[	[	X
dpc-4876	43	33	8	8	NUM
dpc-4876	43	34	]	]	PUNCT
dpc-4876	43	35	.	.	PUNCT
dpc-4876	44	1	also	also	ADV
dpc-4876	44	2	,	,	PUNCT
dpc-4876	44	3	the	the	DET
dpc-4876	44	4	genes	gene	NOUN
dpc-4876	44	5	pax3	pax3	NOUN
dpc-4876	44	6	and	and	CCONJ
dpc-4876	44	7	mite	mite	NOUN
dpc-4876	44	8	play	play	VERB
dpc-4876	44	9	a	a	DET
dpc-4876	44	10	vital	vital	ADJ
dpc-4876	44	11	role	role	NOUN
dpc-4876	44	12	in	in	ADP
dpc-4876	44	13	melanocyte	melanocyte	NOUN
dpc-4876	44	14	stem	stem	NOUN
dpc-4876	44	15	cell	cell	NOUN
dpc-4876	44	16	maintenance	maintenance	NOUN
dpc-4876	44	17	and	and	CCONJ
dpc-4876	44	18	differentiation	differentiation	NOUN
dpc-4876	44	19	,	,	PUNCT
dpc-4876	44	20	with	with	ADP
dpc-4876	44	21	their	their	PRON
dpc-4876	44	22	defective	defective	ADJ
dpc-4876	44	23	functions	function	NOUN
dpc-4876	44	24	being	be	AUX
dpc-4876	44	25	linked	link	VERB
dpc-4876	44	26	to	to	ADP
dpc-4876	44	27	hair	hair	NOUN
dpc-4876	44	28	graying	gray	VERB
dpc-4876	44	29	[	[	X
dpc-4876	44	30	9	9	NUM
dpc-4876	44	31	]	]	PUNCT
dpc-4876	44	32	.	.	PUNCT
dpc-4876	45	1	numerous	numerous	ADJ
dpc-4876	45	2	studies	study	NOUN
dpc-4876	45	3	have	have	AUX
dpc-4876	45	4	demonstrated	demonstrate	VERB
dpc-4876	45	5	relationships	relationship	NOUN
dpc-4876	45	6	between	between	ADP
dpc-4876	45	7	autophagy	autophagy	NOUN
dpc-4876	45	8	and	and	CCONJ
dpc-4876	45	9	the	the	DET
dpc-4876	45	10	regulation	regulation	NOUN
dpc-4876	45	11	of	of	ADP
dpc-4876	45	12	melanocytes	melanocyte	NOUN
dpc-4876	45	13	and	and	CCONJ
dpc-4876	45	14	melanoma	melanoma	NOUN
dpc-4876	45	15	cell	cell	NOUN
dpc-4876	45	16	growth	growth	NOUN
dpc-4876	45	17	,	,	PUNCT
dpc-4876	45	18	senescence	senescence	NOUN
dpc-4876	45	19	,	,	PUNCT
dpc-4876	45	20	and	and	CCONJ
dpc-4876	45	21	death	death	NOUN
dpc-4876	46	1	[	[	X
dpc-4876	46	2	10	10	NUM
dpc-4876	46	3	]	]	PUNCT
dpc-4876	46	4	.	.	PUNCT
dpc-4876	47	1	autophagy	autophagy	PROPN
dpc-4876	47	2	is	be	AUX
dpc-4876	47	3	the	the	DET
dpc-4876	47	4	process	process	NOUN
dpc-4876	47	5	by	by	ADP
dpc-4876	47	6	which	which	PRON
dpc-4876	47	7	cells	cell	NOUN
dpc-4876	47	8	digest	digest	VERB
dpc-4876	47	9	themselves	themselves	PRON
dpc-4876	47	10	by	by	ADP
dpc-4876	47	11	sending	send	VERB
dpc-4876	47	12	cytoplasmic	cytoplasmic	ADJ
dpc-4876	47	13	material	material	NOUN
dpc-4876	47	14	to	to	ADP
dpc-4876	47	15	the	the	DET
dpc-4876	47	16	lysosome	lysosome	NOUN
dpc-4876	47	17	for	for	ADP
dpc-4876	47	18	degradation	degradation	NOUN
dpc-4876	47	19	[	[	X
dpc-4876	47	20	11	11	NUM
dpc-4876	47	21	]	]	PUNCT
dpc-4876	47	22	.	.	PUNCT
dpc-4876	48	1	autophagy	autophagy	PROPN
dpc-4876	48	2	has	have	VERB
dpc-4876	48	3	vital	vital	ADJ
dpc-4876	48	4	roles	role	NOUN
dpc-4876	48	5	in	in	ADP
dpc-4876	48	6	melanogenesis	melanogenesis	NOUN
dpc-4876	48	7	,	,	PUNCT
dpc-4876	48	8	melanosome	melanosome	NOUN
dpc-4876	48	9	transfer	transfer	NOUN
dpc-4876	48	10	,	,	PUNCT
dpc-4876	48	11	and	and	CCONJ
dpc-4876	48	12	pigmentation	pigmentation	NOUN
dpc-4876	48	13	,	,	PUNCT
dpc-4876	48	14	with	with	ADP
dpc-4876	48	15	the	the	DET
dpc-4876	48	16	autophagic	autophagic	ADJ
dpc-4876	48	17	machinery	machinery	NOUN
dpc-4876	48	18	proteins	protein	NOUN
dpc-4876	48	19	promoting	promote	VERB
dpc-4876	48	20	the	the	DET
dpc-4876	48	21	migration	migration	NOUN
dpc-4876	48	22	of	of	ADP
dpc-4876	48	23	developing	develop	VERB
dpc-4876	48	24	melanosomes	melanosome	NOUN
dpc-4876	48	25	within	within	ADP
dpc-4876	48	26	melanocytes	melanocyte	NOUN
dpc-4876	48	27	on	on	ADP
dpc-4876	48	28	microtubules	microtubule	NOUN
dpc-4876	48	29	and	and	CCONJ
dpc-4876	48	30	actin	actin	NOUN
dpc-4876	48	31	filaments	filament	NOUN
dpc-4876	48	32	[	[	X
dpc-4876	48	33	12	12	NUM
dpc-4876	48	34	]	]	PUNCT
dpc-4876	48	35	.	.	PUNCT
dpc-4876	49	1	the	the	DET
dpc-4876	49	2	melanosomes	melanosome	NOUN
dpc-4876	49	3	are	be	AUX
dpc-4876	49	4	transported	transport	VERB
dpc-4876	49	5	to	to	ADP
dpc-4876	49	6	keratinocytes	keratinocyte	NOUN
dpc-4876	49	7	,	,	PUNCT
dpc-4876	49	8	where	where	SCONJ
dpc-4876	49	9	autophagy	autophagy	NOUN
dpc-4876	49	10	restricts	restrict	VERB
dpc-4876	49	11	melanin	melanin	NOUN
dpc-4876	49	12	accumulation	accumulation	NOUN
dpc-4876	49	13	[	[	X
dpc-4876	49	14	13	13	NUM
dpc-4876	49	15	]	]	PUNCT
dpc-4876	49	16	.	.	PUNCT
dpc-4876	50	1	among	among	ADP
dpc-4876	50	2	many	many	ADJ
dpc-4876	50	3	proteins	protein	NOUN
dpc-4876	50	4	known	know	VERB
dpc-4876	50	5	to	to	PART
dpc-4876	50	6	be	be	AUX
dpc-4876	50	7	essential	essential	ADJ
dpc-4876	50	8	to	to	ADP
dpc-4876	50	9	the	the	DET
dpc-4876	50	10	autophagic	autophagic	ADJ
dpc-4876	50	11	process	process	NOUN
dpc-4876	50	12	,	,	PUNCT
dpc-4876	50	13	the	the	DET
dpc-4876	50	14	microtubule	microtubule	NOUN
dpc-4876	50	15	-	-	PUNCT
dpc-4876	50	16	associated	associate	VERB
dpc-4876	50	17	protein	protein	NOUN
dpc-4876	50	18	light	light	NOUN
dpc-4876	50	19	chain	chain	NOUN
dpc-4876	50	20	3	3	NUM
dpc-4876	50	21	(	(	PUNCT
dpc-4876	50	22	lc3	lc3	NOUN
dpc-4876	50	23	)	)	PUNCT
dpc-4876	50	24	plays	play	VERB
dpc-4876	50	25	a	a	DET
dpc-4876	50	26	critical	critical	ADJ
dpc-4876	50	27	role	role	NOUN
dpc-4876	50	28	in	in	ADP
dpc-4876	50	29	autophagy	autophagy	NOUN
dpc-4876	50	30	.	.	PUNCT
dpc-4876	51	1	once	once	ADV
dpc-4876	51	2	synthesized	synthesize	VERB
dpc-4876	51	3	as	as	ADP
dpc-4876	51	4	a	a	DET
dpc-4876	51	5	soluble	soluble	ADJ
dpc-4876	51	6	cytosolic	cytosolic	NOUN
dpc-4876	51	7	form	form	NOUN
dpc-4876	51	8	(	(	PUNCT
dpc-4876	51	9	lc3	lc3	NOUN
dpc-4876	51	10	-	-	PUNCT
dpc-4876	51	11	i	i	NOUN
dpc-4876	51	12	)	)	PUNCT
dpc-4876	51	13	,	,	PUNCT
dpc-4876	51	14	lc3	lc3	NOUN
dpc-4876	51	15	-	-	VERB
dpc-4876	51	16	i	i	PRON
dpc-4876	51	17	is	be	AUX
dpc-4876	51	18	then	then	ADV
dpc-4876	51	19	converted	convert	VERB
dpc-4876	51	20	into	into	ADP
dpc-4876	51	21	a	a	DET
dpc-4876	51	22	membrane	membrane	NOUN
dpc-4876	51	23	-	-	PUNCT
dpc-4876	51	24	bound	bind	VERB
dpc-4876	51	25	form	form	NOUN
dpc-4876	51	26	(	(	PUNCT
dpc-4876	51	27	lc3	lc3	NOUN
dpc-4876	51	28	-	-	PUNCT
dpc-4876	51	29	ii	ii	NOUN
dpc-4876	51	30	)	)	PUNCT
dpc-4876	51	31	via	via	ADP
dpc-4876	51	32	an	an	DET
dpc-4876	51	33	autophagy	autophagy	VERB
dpc-4876	51	34	-	-	PUNCT
dpc-4876	51	35	specific	specific	ADJ
dpc-4876	51	36	conjugation	conjugation	NOUN
dpc-4876	51	37	process	process	NOUN
dpc-4876	51	38	activated	activate	VERB
dpc-4876	51	39	by	by	ADP
dpc-4876	51	40	autophagy	autophagy	ADV
dpc-4876	51	41	-	-	PUNCT
dpc-4876	51	42	related	relate	VERB
dpc-4876	51	43	gene	gene	NOUN
dpc-4876	51	44	(	(	PUNCT
dpc-4876	51	45	atg7&3	atg7&3	PROPN
dpc-4876	51	46	)	)	PUNCT
dpc-4876	51	47	;	;	PUNCT
dpc-4876	51	48	lc3	lc3	NOUN
dpc-4876	51	49	-	-	NOUN
dpc-4876	51	50	ii	ii	PROPN
dpc-4876	51	51	is	be	AUX
dpc-4876	51	52	then	then	ADV
dpc-4876	51	53	recruited	recruit	VERB
dpc-4876	51	54	to	to	ADP
dpc-4876	51	55	the	the	DET
dpc-4876	51	56	autophagosomal	autophagosomal	ADJ
dpc-4876	51	57	membrane	membrane	NOUN
dpc-4876	51	58	[	[	X
dpc-4876	51	59	14	14	NUM
dpc-4876	51	60	]	]	PUNCT
dpc-4876	51	61	.	.	PUNCT
dpc-4876	52	1	a	a	DET
dpc-4876	52	2	study	study	NOUN
dpc-4876	52	3	has	have	AUX
dpc-4876	52	4	attributed	attribute	VERB
dpc-4876	52	5	autophagic	autophagic	ADJ
dpc-4876	52	6	clearance	clearance	NOUN
dpc-4876	52	7	of	of	ADP
dpc-4876	52	8	melanosomes	melanosome	NOUN
dpc-4876	52	9	in	in	ADP
dpc-4876	52	10	keratinocytes	keratinocyte	NOUN
dpc-4876	52	11	based	base	VERB
dpc-4876	52	12	on	on	ADP
dpc-4876	52	13	increased	increase	VERB
dpc-4876	52	14	lc3	lc3	NOUN
dpc-4876	52	15	flux	flux	NOUN
dpc-4876	52	16	,	,	PUNCT
dpc-4876	52	17	which	which	PRON
dpc-4876	52	18	has	have	AUX
dpc-4876	52	19	been	be	AUX
dpc-4876	52	20	linked	link	VERB
dpc-4876	52	21	to	to	ADP
dpc-4876	52	22	the	the	DET
dpc-4876	52	23	ethnic	ethnic	ADJ
dpc-4876	52	24	diversity	diversity	NOUN
dpc-4876	52	25	of	of	ADP
dpc-4876	52	26	skin	skin	NOUN
dpc-4876	52	27	color	color	NOUN
dpc-4876	52	28	[	[	X
dpc-4876	52	29	15	15	NUM
dpc-4876	52	30	]	]	PUNCT
dpc-4876	52	31	.	.	PUNCT
dpc-4876	53	1	therefore	therefore	ADV
dpc-4876	53	2	,	,	PUNCT
dpc-4876	53	3	it	it	PRON
dpc-4876	53	4	is	be	AUX
dpc-4876	53	5	of	of	ADP
dpc-4876	53	6	interest	interest	NOUN
dpc-4876	53	7	to	to	PART
dpc-4876	53	8	study	study	VERB
dpc-4876	53	9	the	the	DET
dpc-4876	53	10	relationship	relationship	NOUN
dpc-4876	53	11	between	between	ADP
dpc-4876	53	12	pgh	pgh	PROPN
dpc-4876	53	13	,	,	PUNCT
dpc-4876	53	14	autophagy	autophagy	ADJ
dpc-4876	53	15	evaluation	evaluation	NOUN
dpc-4876	53	16	through	through	ADP
dpc-4876	53	17	lc3	lc3	NOUN
dpc-4876	53	18	gene	gene	NOUN
dpc-4876	53	19	expression	expression	NOUN
dpc-4876	53	20	by	by	ADP
dpc-4876	53	21	pcr	pcr	PROPN
dpc-4876	53	22	,	,	PUNCT
dpc-4876	53	23	and	and	CCONJ
dpc-4876	53	24	serum	serum	NOUN
dpc-4876	53	25	lc3	lc3	NOUN
dpc-4876	53	26	concentration	concentration	NOUN
dpc-4876	53	27	by	by	ADP
dpc-4876	53	28	elisa	elisa	PROPN
dpc-4876	53	29	.	.	PUNCT
dpc-4876	54	1	methods	method	NOUN
dpc-4876	54	2	a	a	DET
dpc-4876	54	3	case	case	NOUN
dpc-4876	54	4	-	-	PUNCT
dpc-4876	54	5	control	control	NOUN
dpc-4876	54	6	study	study	NOUN
dpc-4876	54	7	was	be	AUX
dpc-4876	54	8	conducted	conduct	VERB
dpc-4876	54	9	on	on	ADP
dpc-4876	54	10	39	39	NUM
dpc-4876	54	11	patients	patient	NOUN
dpc-4876	54	12	with	with	ADP
dpc-4876	54	13	pgh	pgh	PROPN
dpc-4876	54	14	followed	follow	VERB
dpc-4876	54	15	at	at	ADP
dpc-4876	54	16	the	the	DET
dpc-4876	54	17	outpatient	outpatient	NOUN
dpc-4876	54	18	dermatology	dermatology	NOUN
dpc-4876	54	19	clinic	clinic	NOUN
dpc-4876	54	20	and	and	CCONJ
dpc-4876	54	21	21	21	NUM
dpc-4876	54	22	controls	control	NOUN
dpc-4876	54	23	(	(	PUNCT
dpc-4876	54	24	ageand	ageand	NOUN
dpc-4876	54	25	sex	sex	NOUN
dpc-4876	54	26	-	-	PUNCT
dpc-4876	54	27	matched	match	VERB
dpc-4876	54	28	)	)	PUNCT
dpc-4876	54	29	.	.	PUNCT
dpc-4876	55	1	the	the	DET
dpc-4876	55	2	study	study	NOUN
dpc-4876	55	3	was	be	AUX
dpc-4876	55	4	approved	approve	VERB
dpc-4876	55	5	by	by	ADP
dpc-4876	55	6	the	the	DET
dpc-4876	55	7	medical	medical	ADJ
dpc-4876	55	8	research	research	PROPN
dpc-4876	55	9	ethics	ethic	NOUN
dpc-4876	55	10	committee	committee	NOUN
dpc-4876	55	11	at	at	ADP
dpc-4876	55	12	the	the	DET
dpc-4876	55	13	faculty	faculty	NOUN
dpc-4876	55	14	of	of	ADP
dpc-4876	55	15	medicine	medicine	NOUN
dpc-4876	55	16	(	(	PUNCT
dpc-4876	55	17	irb	irb	NOUN
dpc-4876	55	18	;	;	PUNCT
dpc-4876	55	19	soh	soh	NOUN
dpc-4876	55	20	-	-	PUNCT
dpc-4876	55	21	med-22	med-22	NUM
dpc-4876	55	22	-	-	PUNCT
dpc-4876	55	23	11	11	NUM
dpc-4876	55	24	-	-	SYM
dpc-4876	55	25	16	16	NUM
dpc-4876	55	26	)	)	PUNCT
dpc-4876	55	27	.	.	PUNCT
dpc-4876	56	1	informed	informed	ADJ
dpc-4876	56	2	consent	consent	NOUN
dpc-4876	56	3	was	be	AUX
dpc-4876	56	4	obtained	obtain	VERB
dpc-4876	56	5	from	from	ADP
dpc-4876	56	6	all	all	DET
dpc-4876	56	7	participants	participant	NOUN
dpc-4876	56	8	.	.	PUNCT
dpc-4876	57	1	patients	patient	NOUN
dpc-4876	57	2	clinically	clinically	ADV
dpc-4876	57	3	diagnosed	diagnose	VERB
dpc-4876	57	4	with	with	ADP
dpc-4876	57	5	pgh	pgh	PROPN
dpc-4876	57	6	and	and	CCONJ
dpc-4876	57	7	aged	aged	ADJ
dpc-4876	57	8	<	<	X
dpc-4876	57	9	30	30	NUM
dpc-4876	57	10	years	year	NOUN
dpc-4876	57	11	were	be	AUX
dpc-4876	57	12	included	include	VERB
dpc-4876	57	13	in	in	ADP
dpc-4876	57	14	the	the	DET
dpc-4876	57	15	study	study	NOUN
dpc-4876	57	16	.	.	PUNCT
dpc-4876	58	1	exclusion	exclusion	NOUN
dpc-4876	58	2	criteria	criterion	NOUN
dpc-4876	58	3	included	include	VERB
dpc-4876	58	4	patients	patient	NOUN
dpc-4876	58	5	with	with	ADP
dpc-4876	58	6	graying	gray	VERB
dpc-4876	58	7	of	of	ADP
dpc-4876	58	8	hair	hair	NOUN
dpc-4876	58	9	as	as	ADP
dpc-4876	58	10	a	a	DET
dpc-4876	58	11	part	part	NOUN
dpc-4876	58	12	of	of	ADP
dpc-4876	58	13	other	other	ADJ
dpc-4876	58	14	conditions	condition	NOUN
dpc-4876	58	15	such	such	ADJ
dpc-4876	58	16	as	as	ADP
dpc-4876	58	17	vitiligo	vitiligo	NOUN
dpc-4876	58	18	,	,	PUNCT
dpc-4876	58	19	cutaneous	cutaneous	ADJ
dpc-4876	58	20	disease	disease	NOUN
dpc-4876	58	21	involving	involve	VERB
dpc-4876	58	22	the	the	DET
dpc-4876	58	23	scalp	scalp	NOUN
dpc-4876	58	24	,	,	PUNCT
dpc-4876	58	25	and	and	CCONJ
dpc-4876	58	26	pregnant	pregnant	ADJ
dpc-4876	58	27	or	or	CCONJ
dpc-4876	58	28	lactating	lactate	VERB
dpc-4876	58	29	women	woman	NOUN
dpc-4876	58	30	.	.	PUNCT
dpc-4876	59	1	iron	iron	NOUN
dpc-4876	59	2	deficiency	deficiency	NOUN
dpc-4876	59	3	anemia	anemia	NOUN
dpc-4876	59	4	was	be	AUX
dpc-4876	59	5	also	also	ADV
dpc-4876	59	6	excluded	exclude	VERB
dpc-4876	59	7	.	.	PUNCT
dpc-4876	60	1	participant	participant	ADJ
dpc-4876	60	2	assessment	assessment	NOUN
dpc-4876	60	3	all	all	DET
dpc-4876	60	4	participants	participant	NOUN
dpc-4876	60	5	were	be	AUX
dpc-4876	60	6	subjected	subject	VERB
dpc-4876	60	7	to	to	ADP
dpc-4876	60	8	the	the	DET
dpc-4876	60	9	following	following	NOUN
dpc-4876	60	10	:	:	PUNCT
dpc-4876	60	11	1	1	X
dpc-4876	60	12	.	.	PUNCT
dpc-4876	60	13	medical	medical	ADJ
dpc-4876	60	14	history	history	NOUN
dpc-4876	60	15	:	:	PUNCT
dpc-4876	60	16	a	a	DET
dpc-4876	60	17	detailed	detailed	ADJ
dpc-4876	60	18	history	history	NOUN
dpc-4876	60	19	was	be	AUX
dpc-4876	60	20	taken	take	VERB
dpc-4876	60	21	regarding	regard	VERB
dpc-4876	60	22	age	age	NOUN
dpc-4876	60	23	at	at	ADP
dpc-4876	60	24	onset	onset	NOUN
dpc-4876	60	25	,	,	PUNCT
dpc-4876	60	26	origin	origin	NOUN
dpc-4876	60	27	,	,	PUNCT
dpc-4876	60	28	pattern	pattern	NOUN
dpc-4876	60	29	,	,	PUNCT
dpc-4876	60	30	progression	progression	NOUN
dpc-4876	60	31	,	,	PUNCT
dpc-4876	60	32	family	family	NOUN
dpc-4876	60	33	history	history	NOUN
dpc-4876	60	34	,	,	PUNCT
dpc-4876	60	35	and	and	CCONJ
dpc-4876	60	36	personal	personal	ADJ
dpc-4876	60	37	histories	history	NOUN
dpc-4876	60	38	such	such	ADJ
dpc-4876	60	39	as	as	ADP
dpc-4876	60	40	smoking	smoking	NOUN
dpc-4876	60	41	and	and	CCONJ
dpc-4876	60	42	alcohol	alcohol	NOUN
dpc-4876	60	43	intake	intake	NOUN
dpc-4876	60	44	.	.	PUNCT
dpc-4876	61	1	2	2	X
dpc-4876	61	2	.	.	X
dpc-4876	61	3	general	general	ADJ
dpc-4876	61	4	examination	examination	NOUN
dpc-4876	61	5	:	:	PUNCT
dpc-4876	61	6	to	to	PART
dpc-4876	61	7	exclude	exclude	VERB
dpc-4876	61	8	systemic	systemic	ADJ
dpc-4876	61	9	diseases	disease	NOUN
dpc-4876	61	10	(	(	PUNCT
dpc-4876	61	11	anemia	anemia	NOUN
dpc-4876	61	12	,	,	PUNCT
dpc-4876	61	13	thyroid	thyroid	NOUN
dpc-4876	61	14	disorders	disorder	NOUN
dpc-4876	61	15	)	)	PUNCT
dpc-4876	61	16	.	.	PUNCT
dpc-4876	62	1	3	3	X
dpc-4876	62	2	.	.	X
dpc-4876	62	3	dermatological	dermatological	ADJ
dpc-4876	62	4	examination	examination	NOUN
dpc-4876	62	5	:	:	PUNCT
dpc-4876	62	6	general	general	ADJ
dpc-4876	62	7	dermatological	dermatological	ADJ
dpc-4876	62	8	and	and	CCONJ
dpc-4876	62	9	hair	hair	NOUN
dpc-4876	62	10	examinations	examination	NOUN
dpc-4876	62	11	were	be	AUX
dpc-4876	62	12	done	do	VERB
dpc-4876	62	13	.	.	PUNCT
dpc-4876	63	1	a	a	DET
dpc-4876	63	2	local	local	ADJ
dpc-4876	63	3	examination	examination	NOUN
dpc-4876	63	4	of	of	ADP
dpc-4876	63	5	the	the	DET
dpc-4876	63	6	scalp	scalp	NOUN
dpc-4876	63	7	was	be	AUX
dpc-4876	63	8	done	do	VERB
dpc-4876	63	9	to	to	PART
dpc-4876	63	10	detect	detect	VERB
dpc-4876	63	11	any	any	DET
dpc-4876	63	12	abnormality	abnormality	NOUN
dpc-4876	63	13	.	.	PUNCT
dpc-4876	64	1	examination	examination	NOUN
dpc-4876	64	2	of	of	ADP
dpc-4876	64	3	the	the	DET
dpc-4876	64	4	hair	hair	NOUN
dpc-4876	64	5	was	be	AUX
dpc-4876	64	6	done	do	VERB
dpc-4876	64	7	to	to	PART
dpc-4876	64	8	evaluate	evaluate	VERB
dpc-4876	64	9	the	the	DET
dpc-4876	64	10	site	site	NOUN
dpc-4876	64	11	and	and	CCONJ
dpc-4876	64	12	severity	severity	NOUN
dpc-4876	64	13	of	of	ADP
dpc-4876	64	14	hair	hair	NOUN
dpc-4876	64	15	graying	gray	VERB
dpc-4876	64	16	.	.	PUNCT
dpc-4876	65	1	diagnosis	diagnosis	NOUN
dpc-4876	65	2	of	of	ADP
dpc-4876	65	3	pgh	pgh	PROPN
dpc-4876	65	4	was	be	AUX
dpc-4876	65	5	made	make	VERB
dpc-4876	65	6	clinically	clinically	ADV
dpc-4876	65	7	and	and	CCONJ
dpc-4876	65	8	was	be	AUX
dpc-4876	65	9	graded	grade	VERB
dpc-4876	65	10	into	into	ADP
dpc-4876	65	11	three	three	NUM
dpc-4876	65	12	groups	group	NOUN
dpc-4876	65	13	as	as	SCONJ
dpc-4876	65	14	follows	follow	VERB
dpc-4876	65	15	,	,	PUNCT
dpc-4876	65	16	mild	mild	ADJ
dpc-4876	65	17	:	:	PUNCT
dpc-4876	65	18	<	<	X
dpc-4876	65	19	10	10	NUM
dpc-4876	65	20	;	;	PUNCT
dpc-4876	65	21	moderate	moderate	ADJ
dpc-4876	66	1	:	:	PUNCT
dpc-4876	66	2	10–100	10–100	NUM
dpc-4876	66	3	;	;	PUNCT
dpc-4876	66	4	severe	severe	ADJ
dpc-4876	66	5	:	:	PUNCT
dpc-4876	66	6	>	>	PUNCT
dpc-4876	66	7	100	100	NUM
dpc-4876	66	8	gray	gray	ADJ
dpc-4876	66	9	hairs	hair	NOUN
dpc-4876	66	10	.	.	PUNCT
dpc-4876	67	1	4	4	X
dpc-4876	67	2	.	.	X
dpc-4876	67	3	laboratory	laboratory	NOUN
dpc-4876	67	4	investigations	investigation	NOUN
dpc-4876	67	5	,	,	PUNCT
dpc-4876	67	6	including	include	VERB
dpc-4876	67	7	:	:	PUNCT
dpc-4876	67	8	blood	blood	NOUN
dpc-4876	67	9	sample	sample	NOUN
dpc-4876	67	10	blood	blood	NOUN
dpc-4876	67	11	samples	sample	NOUN
dpc-4876	67	12	(	(	PUNCT
dpc-4876	67	13	5	5	NUM
dpc-4876	67	14	cm	cm	NOUN
dpc-4876	67	15	)	)	PUNCT
dpc-4876	67	16	were	be	AUX
dpc-4876	67	17	taken	take	VERB
dpc-4876	67	18	on	on	ADP
dpc-4876	67	19	edta	edta	NOUN
dpc-4876	67	20	tubes	tube	NOUN
dpc-4876	67	21	for	for	ADP
dpc-4876	67	22	examination	examination	NOUN
dpc-4876	67	23	in	in	ADP
dpc-4876	67	24	the	the	DET
dpc-4876	67	25	central	central	ADJ
dpc-4876	67	26	laboratory	laboratory	NOUN
dpc-4876	67	27	of	of	ADP
dpc-4876	67	28	sohag	sohag	PROPN
dpc-4876	67	29	university	university	PROPN
dpc-4876	67	30	,	,	PUNCT
dpc-4876	67	31	egypt	egypt	PROPN
dpc-4876	67	32	.	.	PUNCT
dpc-4876	68	1	a.	a.	PROPN
dpc-4876	68	2	complete	complete	PROPN
dpc-4876	68	3	blood	blood	NOUN
dpc-4876	68	4	count	count	NOUN
dpc-4876	68	5	and	and	CCONJ
dpc-4876	68	6	serum	serum	NOUN
dpc-4876	68	7	ferritin	ferritin	ADJ
dpc-4876	68	8	were	be	AUX
dpc-4876	68	9	done	do	VERB
dpc-4876	68	10	to	to	PART
dpc-4876	68	11	exclude	exclude	VERB
dpc-4876	68	12	iron	iron	NOUN
dpc-4876	68	13	deficiency	deficiency	NOUN
dpc-4876	68	14	anemia	anemia	NOUN
dpc-4876	68	15	.	.	PUNCT
dpc-4876	69	1	b.	b.	PROPN
dpc-4876	69	2	immunohistochemistry	immunohistochemistry	PROPN
dpc-4876	69	3	evaluation	evaluation	NOUN
dpc-4876	69	4	to	to	PART
dpc-4876	69	5	detect	detect	VERB
dpc-4876	69	6	lc3b	lc3b	NOUN
dpc-4876	69	7	protein	protein	NOUN
dpc-4876	69	8	by	by	ADP
dpc-4876	69	9	elisa	elisa	NOUN
dpc-4876	69	10	in	in	ADP
dpc-4876	69	11	the	the	DET
dpc-4876	69	12	serum	serum	NOUN
dpc-4876	69	13	of	of	ADP
dpc-4876	69	14	both	both	DET
dpc-4876	69	15	groups	group	NOUN
dpc-4876	69	16	.	.	PUNCT
dpc-4876	70	1	the	the	DET
dpc-4876	70	2	serum	serum	NOUN
dpc-4876	70	3	was	be	AUX
dpc-4876	70	4	left	leave	VERB
dpc-4876	70	5	to	to	PART
dpc-4876	70	6	coagulate	coagulate	VERB
dpc-4876	70	7	at	at	ADP
dpc-4876	70	8	room	room	NOUN
dpc-4876	70	9	temperature	temperature	NOUN
dpc-4876	70	10	for	for	ADP
dpc-4876	70	11	10	10	NUM
dpc-4876	70	12	-	-	SYM
dpc-4876	70	13	20	20	NUM
dpc-4876	70	14	minutes	minute	NOUN
dpc-4876	70	15	,	,	PUNCT
dpc-4876	70	16	then	then	ADV
dpc-4876	70	17	centrifugation	centrifugation	NOUN
dpc-4876	70	18	20	20	NUM
dpc-4876	70	19	-	-	PUNCT
dpc-4876	70	20	min	min	NOUN
dpc-4876	70	21	at	at	ADP
dpc-4876	70	22	the	the	DET
dpc-4876	70	23	speed	speed	NOUN
dpc-4876	70	24	of	of	ADP
dpc-4876	70	25	3000	3000	NUM
dpc-4876	70	26	r.p.m	r.p.m	NOUN
dpc-4876	70	27	was	be	AUX
dpc-4876	70	28	done	do	VERB
dpc-4876	70	29	.	.	PUNCT
dpc-4876	71	1	the	the	DET
dpc-4876	71	2	specimen	speciman	NOUN
dpc-4876	71	3	was	be	AUX
dpc-4876	71	4	kept	keep	VERB
dpc-4876	71	5	at	at	ADP
dpc-4876	71	6	-20	-20	NUM
dpc-4876	71	7	°	°	NOUN
dpc-4876	71	8	c	c	NOUN
dpc-4876	71	9	to	to	PART
dpc-4876	71	10	be	be	AUX
dpc-4876	71	11	preserved	preserve	VERB
dpc-4876	71	12	until	until	ADP
dpc-4876	71	13	evaluation	evaluation	NOUN
dpc-4876	71	14	.	.	PUNCT
dpc-4876	72	1	human	human	ADJ
dpc-4876	72	2	microtubule	microtubule	NOUN
dpc-4876	72	3	associated	associate	VERB
dpc-4876	72	4	protein	protein	NOUN
dpc-4876	72	5	1	1	NUM
dpc-4876	72	6	light	light	NOUN
dpc-4876	72	7	chain	chain	NOUN
dpc-4876	72	8	3	3	NUM
dpc-4876	72	9	beta	beta	NOUN
dpc-4876	72	10	(	(	PUNCT
dpc-4876	72	11	map1lc3b	map1lc3b	NOUN
dpc-4876	72	12	)	)	PUNCT
dpc-4876	72	13	elisa	elisa	NOUN
dpc-4876	72	14	(	(	PUNCT
dpc-4876	72	15	enzyme	enzyme	NOUN
dpc-4876	72	16	-	-	PUNCT
dpc-4876	72	17	linked	link	VERB
dpc-4876	72	18	immunosorbent	immunosorbent	NOUN
dpc-4876	72	19	assay	assay	NOUN
dpc-4876	72	20	)	)	PUNCT
dpc-4876	72	21	kit	kit	NOUN
dpc-4876	72	22	(	(	PUNCT
dpc-4876	72	23	201	201	NUM
dpc-4876	72	24	-	-	SYM
dpc-4876	72	25	12	12	NUM
dpc-4876	72	26	-	-	PUNCT
dpc-4876	72	27	5566	5566	NUM
dpc-4876	72	28	,	,	PUNCT
dpc-4876	72	29	sunred	sunre	VERB
dpc-4876	72	30	biotechnology	biotechnology	NOUN
dpc-4876	72	31	,	,	PUNCT
dpc-4876	72	32	china	china	PROPN
dpc-4876	72	33	)	)	PUNCT
dpc-4876	72	34	was	be	AUX
dpc-4876	72	35	used	use	VERB
dpc-4876	72	36	.	.	PUNCT
dpc-4876	73	1	first	first	ADV
dpc-4876	73	2	,	,	PUNCT
dpc-4876	73	3	the	the	DET
dpc-4876	73	4	map1lc3b	map1lc3b	NOUN
dpc-4876	73	5	was	be	AUX
dpc-4876	73	6	added	add	VERB
dpc-4876	73	7	to	to	ADP
dpc-4876	73	8	the	the	DET
dpc-4876	73	9	monoclonal	monoclonal	NOUN
dpc-4876	73	10	antibody	antibody	NOUN
dpc-4876	73	11	enzyme	enzyme	NOUN
dpc-4876	73	12	,	,	PUNCT
dpc-4876	73	13	which	which	PRON
dpc-4876	73	14	was	be	AUX
dpc-4876	73	15	pre	pre	VERB
dpc-4876	73	16	-	-	VERB
dpc-4876	73	17	coated	coated	ADJ
dpc-4876	73	18	with	with	ADP
dpc-4876	73	19	human	human	ADJ
dpc-4876	73	20	map1lc3b	map1lc3b	NOUN
dpc-4876	73	21	monoclonal	monoclonal	NOUN
dpc-4876	73	22	antibody	antibody	NOUN
dpc-4876	73	23	,	,	PUNCT
dpc-4876	73	24	incubation	incubation	NOUN
dpc-4876	73	25	for	for	ADP
dpc-4876	73	26	60	60	NUM
dpc-4876	73	27	minutes	minute	NOUN
dpc-4876	73	28	at	at	ADP
dpc-4876	73	29	37	37	NUM
dpc-4876	73	30	°	°	NOUN
dpc-4876	73	31	c	c	X
dpc-4876	73	32	,	,	PUNCT
dpc-4876	73	33	then	then	ADV
dpc-4876	73	34	map1lc3b	map1lc3b	NOUN
dpc-4876	73	35	antibodies	antibody	NOUN
dpc-4876	73	36	labeled	label	VERB
dpc-4876	73	37	with	with	ADP
dpc-4876	73	38	biotin	biotin	NOUN
dpc-4876	73	39	was	be	AUX
dpc-4876	73	40	added	add	VERB
dpc-4876	73	41	and	and	CCONJ
dpc-4876	73	42	combined	combine	VERB
dpc-4876	73	43	with	with	ADP
dpc-4876	73	44	streptavidin	streptavidin	NOUN
dpc-4876	73	45	-	-	NOUN
dpc-4876	73	46	hrp	hrp	PROPN
dpc-4876	73	47	(	(	PUNCT
dpc-4876	73	48	streptavidin	streptavidin	VERB
dpc-4876	73	49	horseradish	horseradish	ADJ
dpc-4876	73	50	peroxidase	peroxidase	NOUN
dpc-4876	73	51	)	)	PUNCT
dpc-4876	73	52	to	to	PART
dpc-4876	73	53	form	form	VERB
dpc-4876	73	54	an	an	DET
dpc-4876	73	55	immune	immune	ADJ
dpc-4876	73	56	complex	complex	NOUN
dpc-4876	73	57	.	.	PUNCT
dpc-4876	74	1	then	then	ADV
dpc-4876	74	2	,	,	PUNCT
dpc-4876	74	3	incubation	incubation	NOUN
dpc-4876	74	4	and	and	CCONJ
dpc-4876	74	5	washing	washing	NOUN
dpc-4876	74	6	were	be	AUX
dpc-4876	74	7	done	do	VERB
dpc-4876	74	8	again	again	ADV
dpc-4876	74	9	to	to	ADP
dpc-4876	74	10	original	original	ADJ
dpc-4876	74	11	article	article	NOUN
dpc-4876	74	12	|	|	ADV
dpc-4876	74	13	dermatol	dermatol	ADJ
dpc-4876	74	14	pract	pract	NOUN
dpc-4876	74	15	concept	concept	NOUN
dpc-4876	74	16	.	.	PUNCT
dpc-4876	75	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	75	2	3	3	NUM
dpc-4876	75	3	remove	remove	VERB
dpc-4876	75	4	the	the	DET
dpc-4876	75	5	uncombined	uncombined	ADJ
dpc-4876	75	6	enzyme	enzyme	NOUN
dpc-4876	75	7	.	.	PUNCT
dpc-4876	76	1	then	then	ADV
dpc-4876	76	2	,	,	PUNCT
dpc-4876	76	3	chromogen	chromogen	NOUN
dpc-4876	76	4	solution	solution	NOUN
dpc-4876	76	5	a	a	PRON
dpc-4876	76	6	&	&	CCONJ
dpc-4876	76	7	b	b	PROPN
dpc-4876	76	8	were	be	AUX
dpc-4876	76	9	added	add	VERB
dpc-4876	76	10	and	and	CCONJ
dpc-4876	76	11	the	the	DET
dpc-4876	76	12	color	color	NOUN
dpc-4876	76	13	of	of	ADP
dpc-4876	76	14	the	the	DET
dpc-4876	76	15	liquid	liquid	NOUN
dpc-4876	76	16	changed	change	VERB
dpc-4876	76	17	to	to	ADP
dpc-4876	76	18	blue.under	blue.under	NOUN
dpc-4876	76	19	the	the	DET
dpc-4876	76	20	effect	effect	NOUN
dpc-4876	76	21	of	of	ADP
dpc-4876	76	22	acid	acid	NOUN
dpc-4876	76	23	,	,	PUNCT
dpc-4876	76	24	the	the	DET
dpc-4876	76	25	color	color	NOUN
dpc-4876	76	26	became	become	VERB
dpc-4876	76	27	yellow	yellow	ADJ
dpc-4876	76	28	.	.	PUNCT
dpc-4876	77	1	the	the	DET
dpc-4876	77	2	chroma	chroma	NOUN
dpc-4876	77	3	of	of	ADP
dpc-4876	77	4	the	the	DET
dpc-4876	77	5	color	color	NOUN
dpc-4876	77	6	and	and	CCONJ
dpc-4876	77	7	the	the	DET
dpc-4876	77	8	concentration	concentration	NOUN
dpc-4876	77	9	of	of	ADP
dpc-4876	77	10	the	the	DET
dpc-4876	77	11	human	human	ADJ
dpc-4876	77	12	substance	substance	NOUN
dpc-4876	77	13	map1lc3b	map1lc3b	NOUN
dpc-4876	77	14	of	of	ADP
dpc-4876	77	15	samples	sample	NOUN
dpc-4876	77	16	were	be	AUX
dpc-4876	77	17	positively	positively	ADV
dpc-4876	77	18	correlated	correlate	VERB
dpc-4876	77	19	.	.	PUNCT
dpc-4876	78	1	the	the	DET
dpc-4876	78	2	sensitivity	sensitivity	NOUN
dpc-4876	78	3	of	of	ADP
dpc-4876	78	4	this	this	DET
dpc-4876	78	5	assay	assay	NOUN
dpc-4876	78	6	,	,	PUNCT
dpc-4876	78	7	defined	define	VERB
dpc-4876	78	8	as	as	ADP
dpc-4876	78	9	the	the	DET
dpc-4876	78	10	lowest	low	ADJ
dpc-4876	78	11	protein	protein	NOUN
dpc-4876	78	12	concentration	concentration	NOUN
dpc-4876	78	13	that	that	PRON
dpc-4876	78	14	could	could	AUX
dpc-4876	78	15	be	be	AUX
dpc-4876	78	16	differentiated	differentiate	VERB
dpc-4876	78	17	from	from	ADP
dpc-4876	78	18	zero	zero	NUM
dpc-4876	78	19	,	,	PUNCT
dpc-4876	78	20	was	be	AUX
dpc-4876	78	21	determined	determine	VERB
dpc-4876	78	22	by	by	ADP
dpc-4876	78	23	subtracting	subtract	VERB
dpc-4876	78	24	two	two	NUM
dpc-4876	78	25	standard	standard	ADJ
dpc-4876	78	26	deviations	deviation	NOUN
dpc-4876	78	27	from	from	ADP
dpc-4876	78	28	the	the	DET
dpc-4876	78	29	mean	mean	ADJ
dpc-4876	78	30	optical	optical	ADJ
dpc-4876	78	31	density	density	NOUN
dpc-4876	78	32	value	value	NOUN
dpc-4876	78	33	of	of	ADP
dpc-4876	78	34	twenty	twenty	NUM
dpc-4876	78	35	-	-	PUNCT
dpc-4876	78	36	zero	zero	NUM
dpc-4876	78	37	standard	standard	ADJ
dpc-4876	78	38	replicates	replicate	NOUN
dpc-4876	78	39	and	and	CCONJ
dpc-4876	78	40	calculating	calculate	VERB
dpc-4876	78	41	the	the	DET
dpc-4876	78	42	corresponding	corresponding	ADJ
dpc-4876	78	43	concentration	concentration	NOUN
dpc-4876	78	44	.	.	PUNCT
dpc-4876	79	1	the	the	DET
dpc-4876	79	2	assay	assay	PROPN
dpc-4876	79	3	range	range	NOUN
dpc-4876	79	4	was	be	AUX
dpc-4876	79	5	0.5	0.5	NUM
dpc-4876	79	6	-	-	PUNCT
dpc-4876	79	7	150ng	150ng	NOUN
dpc-4876	79	8	/	/	SYM
dpc-4876	79	9	ml	ml	PROPN
dpc-4876	79	10	.	.	PUNCT
dpc-4876	79	11	hair	hair	NOUN
dpc-4876	79	12	samples	sample	NOUN
dpc-4876	79	13	at	at	ADP
dpc-4876	79	14	least	least	ADJ
dpc-4876	79	15	six	six	NUM
dpc-4876	79	16	white	white	ADJ
dpc-4876	79	17	hairs	hair	NOUN
dpc-4876	79	18	from	from	ADP
dpc-4876	79	19	patients	patient	NOUN
dpc-4876	79	20	with	with	ADP
dpc-4876	79	21	pgh	pgh	PROPN
dpc-4876	79	22	and	and	CCONJ
dpc-4876	79	23	six	six	NUM
dpc-4876	79	24	normal	normal	ADJ
dpc-4876	79	25	hairs	hair	NOUN
dpc-4876	79	26	from	from	ADP
dpc-4876	79	27	controls	control	NOUN
dpc-4876	79	28	were	be	AUX
dpc-4876	79	29	collected	collect	VERB
dpc-4876	79	30	by	by	ADP
dpc-4876	79	31	hair	hair	NOUN
dpc-4876	79	32	plucking	pluck	VERB
dpc-4876	79	33	to	to	AUX
dpc-4876	79	34	detect	detect	VERB
dpc-4876	79	35	lc3b	lc3b	NOUN
dpc-4876	79	36	gene	gene	NOUN
dpc-4876	79	37	expression	expression	NOUN
dpc-4876	79	38	by	by	ADP
dpc-4876	79	39	polymerase	polymerase	NOUN
dpc-4876	79	40	chain	chain	NOUN
dpc-4876	79	41	reaction	reaction	NOUN
dpc-4876	79	42	(	(	PUNCT
dpc-4876	79	43	pcr	pcr	NOUN
dpc-4876	79	44	)	)	PUNCT
dpc-4876	79	45	in	in	ADP
dpc-4876	79	46	the	the	DET
dpc-4876	79	47	national	national	ADJ
dpc-4876	79	48	research	research	PROPN
dpc-4876	79	49	centre	centre	PROPN
dpc-4876	79	50	(	(	PUNCT
dpc-4876	79	51	nrc	nrc	PROPN
dpc-4876	79	52	)	)	PUNCT
dpc-4876	79	53	,	,	PUNCT
dpc-4876	79	54	cairo	cairo	PROPN
dpc-4876	79	55	,	,	PUNCT
dpc-4876	79	56	egypt	egypt	PROPN
dpc-4876	79	57	.	.	PUNCT
dpc-4876	80	1	hair	hair	NOUN
dpc-4876	80	2	samples	sample	NOUN
dpc-4876	80	3	were	be	AUX
dpc-4876	80	4	processed	process	VERB
dpc-4876	80	5	with	with	ADP
dpc-4876	80	6	the	the	DET
dpc-4876	80	7	following	follow	VERB
dpc-4876	80	8	four	four	NUM
dpc-4876	80	9	steps	step	NOUN
dpc-4876	80	10	:	:	PUNCT
dpc-4876	80	11	extraction	extraction	NOUN
dpc-4876	80	12	of	of	ADP
dpc-4876	80	13	rna	rna	NOUN
dpc-4876	80	14	from	from	ADP
dpc-4876	80	15	hair	hair	NOUN
dpc-4876	80	16	samples	sample	NOUN
dpc-4876	80	17	;	;	PUNCT
dpc-4876	80	18	reverse	reverse	VERB
dpc-4876	80	19	transcription	transcription	NOUN
dpc-4876	80	20	into	into	ADP
dpc-4876	80	21	cdna	cdna	PROPN
dpc-4876	80	22	;	;	PUNCT
dpc-4876	80	23	real	real	ADJ
dpc-4876	80	24	-	-	PUNCT
dpc-4876	80	25	time	time	NOUN
dpc-4876	80	26	pcr	pcr	ADJ
dpc-4876	80	27	quantification	quantification	NOUN
dpc-4876	80	28	;	;	PUNCT
dpc-4876	80	29	interpretation	interpretation	NOUN
dpc-4876	80	30	of	of	ADP
dpc-4876	80	31	the	the	DET
dpc-4876	80	32	result	result	NOUN
dpc-4876	80	33	.	.	PUNCT
dpc-4876	81	1	extraction	extraction	NOUN
dpc-4876	81	2	of	of	ADP
dpc-4876	81	3	rna	rna	NOUN
dpc-4876	81	4	from	from	ADP
dpc-4876	81	5	whole	whole	ADJ
dpc-4876	81	6	hair	hair	NOUN
dpc-4876	81	7	samples	sample	VERB
dpc-4876	81	8	total	total	ADJ
dpc-4876	81	9	cellular	cellular	ADJ
dpc-4876	81	10	rna	rna	NOUN
dpc-4876	81	11	was	be	AUX
dpc-4876	81	12	extracted	extract	VERB
dpc-4876	81	13	from	from	ADP
dpc-4876	81	14	all	all	DET
dpc-4876	81	15	hair	hair	NOUN
dpc-4876	81	16	samples	sample	NOUN
dpc-4876	81	17	with	with	ADP
dpc-4876	81	18	the	the	DET
dpc-4876	81	19	qiaamp	qiaamp	PROPN
dpc-4876	81	20	®	®	PROPN
dpc-4876	81	21	rna	rna	NOUN
dpc-4876	81	22	mini	mini	ADJ
dpc-4876	81	23	kit	kit	NOUN
dpc-4876	81	24	(	(	PUNCT
dpc-4876	81	25	52904	52904	NUM
dpc-4876	81	26	,	,	PUNCT
dpc-4876	81	27	qiagen	qiagen	PROPN
dpc-4876	81	28	,	,	PUNCT
dpc-4876	81	29	germany	germany	PROPN
dpc-4876	81	30	)	)	PUNCT
dpc-4876	81	31	.	.	PUNCT
dpc-4876	82	1	all	all	DET
dpc-4876	82	2	preparation	preparation	NOUN
dpc-4876	82	3	and	and	CCONJ
dpc-4876	82	4	handling	handling	NOUN
dpc-4876	82	5	steps	step	NOUN
dpc-4876	82	6	of	of	ADP
dpc-4876	82	7	rna	rna	NOUN
dpc-4876	82	8	took	take	VERB
dpc-4876	82	9	place	place	NOUN
dpc-4876	82	10	in	in	ADP
dpc-4876	82	11	a	a	DET
dpc-4876	82	12	laminar	laminar	ADJ
dpc-4876	82	13	flow	flow	NOUN
dpc-4876	82	14	hood	hood	NOUN
dpc-4876	82	15	under	under	ADP
dpc-4876	82	16	rnase	rnase	NOUN
dpc-4876	82	17	-	-	PUNCT
dpc-4876	82	18	free	free	ADJ
dpc-4876	82	19	conditions	condition	NOUN
dpc-4876	82	20	.	.	PUNCT
dpc-4876	83	1	reverse	reverse	ADJ
dpc-4876	83	2	transcription	transcription	NOUN
dpc-4876	83	3	into	into	ADP
dpc-4876	83	4	cdna	cdna	PROPN
dpc-4876	83	5	total	total	PROPN
dpc-4876	83	6	rna	rna	PROPN
dpc-4876	83	7	was	be	AUX
dpc-4876	83	8	reversely	reversely	ADV
dpc-4876	83	9	transcripted	transcripte	VERB
dpc-4876	83	10	to	to	ADP
dpc-4876	83	11	cdna	cdna	PROPN
dpc-4876	83	12	using	use	VERB
dpc-4876	83	13	a	a	DET
dpc-4876	83	14	high	high	ADJ
dpc-4876	83	15	-	-	PUNCT
dpc-4876	83	16	capacity	capacity	NOUN
dpc-4876	83	17	cdna	cdna	NOUN
dpc-4876	83	18	reverse	reverse	NOUN
dpc-4876	83	19	transcription	transcription	NOUN
dpc-4876	83	20	kit	kit	NOUN
dpc-4876	83	21	(	(	PUNCT
dpc-4876	83	22	4368814	4368814	NUM
dpc-4876	83	23	,	,	PUNCT
dpc-4876	83	24	applied	apply	VERB
dpc-4876	83	25	biosystems	biosystem	NOUN
dpc-4876	83	26	™	™	NOUN
dpc-4876	83	27	,	,	PUNCT
dpc-4876	83	28	usa	usa	PROPN
dpc-4876	83	29	)	)	PUNCT
dpc-4876	83	30	.	.	PUNCT
dpc-4876	84	1	real	real	ADJ
dpc-4876	84	2	-	-	PUNCT
dpc-4876	84	3	time	time	NOUN
dpc-4876	84	4	pcr	pcr	ADJ
dpc-4876	84	5	quantification	quantification	NOUN
dpc-4876	84	6	a	a	DET
dpc-4876	84	7	real	real	ADJ
dpc-4876	84	8	-	-	PUNCT
dpc-4876	84	9	time	time	NOUN
dpc-4876	84	10	quantitative	quantitative	ADJ
dpc-4876	84	11	rt	rt	NOUN
dpc-4876	84	12	-	-	PUNCT
dpc-4876	84	13	pcr	pcr	PROPN
dpc-4876	84	14	(	(	PUNCT
dpc-4876	84	15	rq	rq	NOUN
dpc-4876	84	16	-	-	PUNCT
dpc-4876	84	17	pcr	pcr	ADJ
dpc-4876	84	18	)	)	PUNCT
dpc-4876	84	19	based	base	VERB
dpc-4876	84	20	on	on	ADP
dpc-4876	84	21	taqman	taqman	NOUN
dpc-4876	84	22	fluorescence	fluorescence	NOUN
dpc-4876	84	23	methodology	methodology	NOUN
dpc-4876	84	24	(	(	PUNCT
dpc-4876	84	25	4333458	4333458	NUM
dpc-4876	84	26	,	,	PUNCT
dpc-4876	84	27	applied	apply	VERB
dpc-4876	84	28	biosystems	biosystem	NOUN
dpc-4876	84	29	™	™	PROPN
dpc-4876	84	30	,	,	PUNCT
dpc-4876	84	31	usa	usa	PROPN
dpc-4876	84	32	)	)	PUNCT
dpc-4876	84	33	was	be	AUX
dpc-4876	84	34	used	use	VERB
dpc-4876	84	35	for	for	ADP
dpc-4876	84	36	lc3b	lc3b	NOUN
dpc-4876	84	37	quantitation	quantitation	NOUN
dpc-4876	84	38	.	.	PUNCT
dpc-4876	85	1	amplification	amplification	NOUN
dpc-4876	85	2	of	of	ADP
dpc-4876	85	3	cdna	cdna	PROPN
dpc-4876	85	4	using	use	VERB
dpc-4876	85	5	taqman	taqman	NOUN
dpc-4876	85	6	master	master	NOUN
dpc-4876	85	7	mix	mix	NOUN
dpc-4876	85	8	(	(	PUNCT
dpc-4876	85	9	16495	16495	NUM
dpc-4876	85	10	,	,	PUNCT
dpc-4876	85	11	applied	apply	VERB
dpc-4876	85	12	biosystems	biosystem	NOUN
dpc-4876	85	13	™	™	PROPN
dpc-4876	85	14	,	,	PUNCT
dpc-4876	85	15	usa	usa	PROPN
dpc-4876	85	16	)	)	PUNCT
dpc-4876	85	17	and	and	CCONJ
dpc-4876	85	18	primer	primer	NOUN
dpc-4876	85	19	assay	assay	NOUN
dpc-4876	85	20	of	of	ADP
dpc-4876	85	21	the	the	DET
dpc-4876	85	22	gene	gene	NOUN
dpc-4876	85	23	using	use	VERB
dpc-4876	85	24	real	real	ADJ
dpc-4876	85	25	-	-	PUNCT
dpc-4876	85	26	time	time	NOUN
dpc-4876	85	27	pcr	pcr	NOUN
dpc-4876	85	28	.	.	PUNCT
dpc-4876	86	1	procedure	procedure	NOUN
dpc-4876	86	2	:	:	PUNCT
dpc-4876	86	3	1	1	X
dpc-4876	86	4	.	.	X
dpc-4876	86	5	total	total	ADJ
dpc-4876	86	6	pcr	pcr	ADJ
dpc-4876	86	7	volume	volume	NOUN
dpc-4876	86	8	was	be	AUX
dpc-4876	86	9	25	25	NUM
dpc-4876	86	10	µl	µl	ADP
dpc-4876	86	11	,	,	PUNCT
dpc-4876	86	12	including	include	VERB
dpc-4876	86	13	5	5	NUM
dpc-4876	86	14	µl	µl	NOUN
dpc-4876	86	15	of	of	ADP
dpc-4876	86	16	rt	rt	PROPN
dpc-4876	86	17	reaction	reaction	NOUN
dpc-4876	86	18	,	,	PUNCT
dpc-4876	86	19	10	10	NUM
dpc-4876	86	20	µl	µl	ADP
dpc-4876	86	21	taqman	taqman	NOUN
dpc-4876	86	22	universal	universal	ADJ
dpc-4876	86	23	pcr	pcr	PROPN
dpc-4876	86	24	master	master	NOUN
dpc-4876	86	25	mix	mix	NOUN
dpc-4876	86	26	(	(	PUNCT
dpc-4876	86	27	10	10	NUM
dpc-4876	86	28	µm	µm	NOUN
dpc-4876	86	29	)	)	PUNCT
dpc-4876	86	30	,	,	PUNCT
dpc-4876	86	31	1	1	NUM
dpc-4876	86	32	µl	µl	ADP
dpc-4876	86	33	primer	primer	NOUN
dpc-4876	86	34	,	,	PUNCT
dpc-4876	86	35	and	and	CCONJ
dpc-4876	86	36	probe	probe	VERB
dpc-4876	86	37	assay	assay	NOUN
dpc-4876	86	38	mix	mix	NOUN
dpc-4876	86	39	of	of	ADP
dpc-4876	86	40	each	each	DET
dpc-4876	86	41	gene	gene	NOUN
dpc-4876	86	42	(	(	PUNCT
dpc-4876	86	43	lc3b	lc3b	PROPN
dpc-4876	86	44	)	)	PUNCT
dpc-4876	86	45	(	(	PUNCT
dpc-4876	86	46	10	10	NUM
dpc-4876	86	47	µm	µm	NOUN
dpc-4876	86	48	)	)	PUNCT
dpc-4876	86	49	was	be	AUX
dpc-4876	86	50	completed	complete	VERB
dpc-4876	86	51	for	for	ADP
dpc-4876	86	52	a	a	DET
dpc-4876	86	53	total	total	ADJ
dpc-4876	86	54	volume	volume	NOUN
dpc-4876	86	55	by	by	ADP
dpc-4876	86	56	adding	add	VERB
dpc-4876	86	57	9	9	NUM
dpc-4876	86	58	µl	µl	ADP
dpc-4876	86	59	distilled	distil	VERB
dpc-4876	86	60	water	water	NOUN
dpc-4876	86	61	.	.	PUNCT
dpc-4876	87	1	2	2	X
dpc-4876	87	2	.	.	X
dpc-4876	87	3	gapdh	gapdh	NOUN
dpc-4876	87	4	was	be	AUX
dpc-4876	87	5	used	use	VERB
dpc-4876	87	6	as	as	ADP
dpc-4876	87	7	a	a	DET
dpc-4876	87	8	reference	reference	NOUN
dpc-4876	87	9	gene	gene	NOUN
dpc-4876	87	10	or	or	CCONJ
dpc-4876	87	11	internal	internal	ADJ
dpc-4876	87	12	control	control	NOUN
dpc-4876	87	13	:	:	PUNCT
dpc-4876	87	14	sense	sense	NOUN
dpc-4876	87	15	,	,	PUNCT
dpc-4876	87	16	5	5	NUM
dpc-4876	87	17	-	-	SYM
dpc-4876	87	18	cctcaagatcatcagcaat-3	cctcaagatcatcagcaat-3	NOUN
dpc-4876	87	19	;	;	PUNCT
dpc-4876	87	20	antisense	antisense	NOUN
dpc-4876	87	21	,	,	PUNCT
dpc-4876	87	22	5’-ccatccacagtcttctgggt-3	5’-ccatccacagtcttctgggt-3	NUM
dpc-4876	87	23	’	'	PUNCT
dpc-4876	87	24	;	;	PUNCT
dpc-4876	87	25	probe	probe	NOUN
dpc-4876	87	26	,	,	PUNCT
dpc-4876	87	27	5’-fam	5’-fam	NUM
dpc-4876	87	28	-	-	PUNCT
dpc-4876	87	29	accacagtccatgccatcac	accacagtccatgccatcac	NOUN
dpc-4876	87	30	-	-	PUNCT
dpc-4876	87	31	tam	tam	NOUN
dpc-4876	87	32	ra-3	ra-3	NOUN
dpc-4876	87	33	’	'	PUNCT
dpc-4876	87	34	3	3	NUM
dpc-4876	87	35	.	.	PUNCT
dpc-4876	87	36	pcr	pcr	ADJ
dpc-4876	87	37	cycling	cycling	NOUN
dpc-4876	87	38	conditions	condition	NOUN
dpc-4876	87	39	were	be	AUX
dpc-4876	87	40	as	as	SCONJ
dpc-4876	87	41	follows	follow	VERB
dpc-4876	87	42	:	:	PUNCT
dpc-4876	87	43	denaturing	denature	VERB
dpc-4876	87	44	at	at	ADP
dpc-4876	87	45	94	94	NUM
dpc-4876	87	46	°	°	ADP
dpc-4876	87	47	c	c	NOUN
dpc-4876	87	48	for	for	ADP
dpc-4876	87	49	20	20	NUM
dpc-4876	87	50	s	s	NOUN
dpc-4876	87	51	,	,	PUNCT
dpc-4876	87	52	followed	follow	VERB
dpc-4876	87	53	by	by	ADP
dpc-4876	87	54	annealing	anneal	VERB
dpc-4876	87	55	at	at	ADP
dpc-4876	87	56	56	56	NUM
dpc-4876	87	57	°	°	NOUN
dpc-4876	87	58	c	c	NOUN
dpc-4876	87	59	for	for	ADP
dpc-4876	87	60	20	20	NUM
dpc-4876	87	61	s	s	NOUN
dpc-4876	87	62	,	,	PUNCT
dpc-4876	87	63	and	and	CCONJ
dpc-4876	87	64	extension	extension	NOUN
dpc-4876	87	65	at	at	ADP
dpc-4876	87	66	72	72	NUM
dpc-4876	87	67	°	°	ADP
dpc-4876	87	68	c	c	NOUN
dpc-4876	87	69	for	for	ADP
dpc-4876	87	70	30	30	NUM
dpc-4876	87	71	s	s	NOUN
dpc-4876	87	72	,	,	PUNCT
dpc-4876	87	73	80	80	NUM
dpc-4876	87	74	°	°	NUM
dpc-4876	87	75	c	c	NOUN
dpc-4876	87	76	for	for	ADP
dpc-4876	87	77	20	20	NUM
dpc-4876	87	78	s.	s.	PROPN
dpc-4876	87	79	4	4	NUM
dpc-4876	87	80	.	.	PUNCT
dpc-4876	88	1	quantification	quantification	NOUN
dpc-4876	88	2	of	of	ADP
dpc-4876	88	3	pcr	pcr	ADJ
dpc-4876	88	4	product	product	NOUN
dpc-4876	88	5	after	after	SCONJ
dpc-4876	88	6	normalization	normalization	NOUN
dpc-4876	88	7	to	to	ADP
dpc-4876	88	8	gapdh	gapdh	NOUN
dpc-4876	88	9	gene	gene	NOUN
dpc-4876	88	10	expression	expression	NOUN
dpc-4876	88	11	was	be	AUX
dpc-4876	88	12	done	do	VERB
dpc-4876	88	13	and	and	CCONJ
dpc-4876	88	14	calculated	calculate	VERB
dpc-4876	88	15	relative	relative	ADJ
dpc-4876	88	16	to	to	ADP
dpc-4876	88	17	the	the	DET
dpc-4876	88	18	untreated	untreated	ADJ
dpc-4876	88	19	control	control	PROPN
dpc-4876	88	20	group	group	NOUN
dpc-4876	88	21	.	.	PUNCT
dpc-4876	89	1	interpretation	interpretation	NOUN
dpc-4876	89	2	of	of	ADP
dpc-4876	89	3	the	the	DET
dpc-4876	89	4	result	result	NOUN
dpc-4876	89	5	:	:	PUNCT
dpc-4876	89	6	the	the	DET
dpc-4876	89	7	relative	relative	NOUN
dpc-4876	89	8	of	of	ADP
dpc-4876	89	9	both	both	DET
dpc-4876	89	10	lc3b	lc3b	ADJ
dpc-4876	89	11	expressions	expression	NOUN
dpc-4876	89	12	in	in	ADP
dpc-4876	89	13	a	a	DET
dpc-4876	89	14	sample	sample	NOUN
dpc-4876	89	15	was	be	AUX
dpc-4876	89	16	determined	determine	VERB
dpc-4876	89	17	by	by	ADP
dpc-4876	89	18	subtracting	subtract	VERB
dpc-4876	89	19	the	the	DET
dpc-4876	89	20	cycle	cycle	NOUN
dpc-4876	89	21	threshold	threshold	NOUN
dpc-4876	89	22	of	of	ADP
dpc-4876	89	23	the	the	DET
dpc-4876	89	24	reference	reference	NOUN
dpc-4876	89	25	gene	gene	NOUN
dpc-4876	89	26	(	(	PUNCT
dpc-4876	89	27	gapdh	gapdh	NOUN
dpc-4876	89	28	)	)	PUNCT
dpc-4876	89	29	from	from	ADP
dpc-4876	89	30	that	that	PRON
dpc-4876	89	31	of	of	ADP
dpc-4876	89	32	the	the	DET
dpc-4876	89	33	target	target	NOUN
dpc-4876	89	34	gene	gene	NOUN
dpc-4876	89	35	(	(	PUNCT
dpc-4876	89	36	lc3b	lc3b	NOUN
dpc-4876	89	37	)	)	PUNCT
dpc-4876	89	38	expression	expression	NOUN
dpc-4876	89	39	getting	get	VERB
dpc-4876	89	40	the	the	DET
dpc-4876	89	41	normalized	normalize	VERB
dpc-4876	89	42	amount	amount	NOUN
dpc-4876	89	43	of	of	ADP
dpc-4876	89	44	the	the	DET
dpc-4876	89	45	mrna	mrna	NOUN
dpc-4876	89	46	,	,	PUNCT
dpc-4876	89	47	then	then	ADV
dpc-4876	89	48	the	the	DET
dpc-4876	89	49	value	value	NOUN
dpc-4876	89	50	was	be	AUX
dpc-4876	89	51	compared	compare	VERB
dpc-4876	89	52	to	to	ADP
dpc-4876	89	53	that	that	PRON
dpc-4876	89	54	of	of	ADP
dpc-4876	89	55	the	the	DET
dpc-4876	89	56	calibrators	calibrator	NOUN
dpc-4876	89	57	.	.	PUNCT
dpc-4876	90	1	statistical	statistical	ADJ
dpc-4876	90	2	analysis	analysis	NOUN
dpc-4876	90	3	data	datum	NOUN
dpc-4876	90	4	were	be	AUX
dpc-4876	90	5	verified	verify	VERB
dpc-4876	90	6	,	,	PUNCT
dpc-4876	90	7	coded	code	VERB
dpc-4876	90	8	by	by	ADP
dpc-4876	90	9	the	the	DET
dpc-4876	90	10	researcher	researcher	NOUN
dpc-4876	90	11	,	,	PUNCT
dpc-4876	90	12	and	and	CCONJ
dpc-4876	90	13	analyzed	analyze	VERB
dpc-4876	90	14	using	use	VERB
dpc-4876	90	15	spss	spss	PROPN
dpc-4876	90	16	version	version	NOUN
dpc-4876	90	17	24	24	NUM
dpc-4876	90	18	.	.	PUNCT
dpc-4876	91	1	descriptive	descriptive	ADJ
dpc-4876	91	2	statistics	statistic	NOUN
dpc-4876	91	3	:	:	PUNCT
dpc-4876	91	4	means	mean	NOUN
dpc-4876	91	5	,	,	PUNCT
dpc-4876	91	6	standard	standard	ADJ
dpc-4876	91	7	deviations	deviation	NOUN
dpc-4876	91	8	,	,	PUNCT
dpc-4876	91	9	median	median	ADJ
dpc-4876	91	10	,	,	PUNCT
dpc-4876	91	11	range	range	NOUN
dpc-4876	91	12	,	,	PUNCT
dpc-4876	91	13	and	and	CCONJ
dpc-4876	91	14	percentages	percentage	NOUN
dpc-4876	91	15	were	be	AUX
dpc-4876	91	16	calculated	calculate	VERB
dpc-4876	91	17	.	.	PUNCT
dpc-4876	92	1	test	test	NOUN
dpc-4876	92	2	of	of	ADP
dpc-4876	92	3	significances	significance	NOUN
dpc-4876	92	4	:	:	PUNCT
dpc-4876	92	5	chi	chi	ADJ
dpc-4876	92	6	-	-	PUNCT
dpc-4876	92	7	squared	square	VERB
dpc-4876	92	8	test	test	NOUN
dpc-4876	92	9	was	be	AUX
dpc-4876	92	10	used	use	VERB
dpc-4876	92	11	to	to	PART
dpc-4876	92	12	compare	compare	VERB
dpc-4876	92	13	the	the	DET
dpc-4876	92	14	difference	difference	NOUN
dpc-4876	92	15	in	in	ADP
dpc-4876	92	16	the	the	DET
dpc-4876	92	17	distribution	distribution	NOUN
dpc-4876	92	18	of	of	ADP
dpc-4876	92	19	frequencies	frequency	NOUN
dpc-4876	92	20	among	among	ADP
dpc-4876	92	21	different	different	ADJ
dpc-4876	92	22	groups	group	NOUN
dpc-4876	92	23	.	.	PUNCT
dpc-4876	93	1	a	a	DET
dpc-4876	93	2	test	test	NOUN
dpc-4876	93	3	of	of	ADP
dpc-4876	93	4	normality	normality	NOUN
dpc-4876	93	5	for	for	ADP
dpc-4876	93	6	the	the	DET
dpc-4876	93	7	main	main	ADJ
dpc-4876	93	8	variables	variable	NOUN
dpc-4876	93	9	was	be	AUX
dpc-4876	93	10	carried	carry	VERB
dpc-4876	93	11	out	out	ADP
dpc-4876	93	12	using	use	VERB
dpc-4876	93	13	the	the	DET
dpc-4876	93	14	shapiro	shapiro	PROPN
dpc-4876	93	15	-	-	PUNCT
dpc-4876	93	16	wilk	wilk	NOUN
dpc-4876	93	17	test	test	NOUN
dpc-4876	93	18	.	.	PUNCT
dpc-4876	94	1	independent	independent	ADJ
dpc-4876	94	2	t	t	PROPN
dpc-4876	94	3	-	-	PUNCT
dpc-4876	94	4	test/	test/	NUM
dpc-4876	94	5	mann	mann	PROPN
dpc-4876	94	6	-	-	PUNCT
dpc-4876	94	7	whitney	whitney	PROPN
dpc-4876	94	8	u	u	PROPN
dpc-4876	94	9	test	test	NOUN
dpc-4876	94	10	analysis	analysis	NOUN
dpc-4876	94	11	was	be	AUX
dpc-4876	94	12	carried	carry	VERB
dpc-4876	94	13	out	out	ADP
dpc-4876	94	14	to	to	PART
dpc-4876	94	15	compare	compare	VERB
dpc-4876	94	16	the	the	DET
dpc-4876	94	17	means	mean	NOUN
dpc-4876	94	18	of	of	ADP
dpc-4876	94	19	normally	normally	ADV
dpc-4876	94	20	/	/	SYM
dpc-4876	94	21	not	not	PART
dpc-4876	94	22	normally	normally	ADV
dpc-4876	94	23	distributed	distribute	VERB
dpc-4876	94	24	binary	binary	ADJ
dpc-4876	94	25	data	datum	NOUN
dpc-4876	94	26	,	,	PUNCT
dpc-4876	94	27	respectively	respectively	ADV
dpc-4876	94	28	.	.	PUNCT
dpc-4876	95	1	for	for	ADP
dpc-4876	95	2	non	non	ADJ
dpc-4876	95	3	-	-	ADJ
dpc-4876	95	4	parametric	parametric	ADJ
dpc-4876	95	5	variables	variable	NOUN
dpc-4876	95	6	with	with	ADP
dpc-4876	95	7	more	more	ADJ
dpc-4876	95	8	than	than	ADP
dpc-4876	95	9	two	two	NUM
dpc-4876	95	10	categories	category	NOUN
dpc-4876	95	11	,	,	PUNCT
dpc-4876	95	12	the	the	DET
dpc-4876	95	13	kruskal	kruskal	PROPN
dpc-4876	95	14	wallis	wallis	PROPN
dpc-4876	95	15	test	test	PROPN
dpc-4876	95	16	was	be	AUX
dpc-4876	95	17	used	use	VERB
dpc-4876	95	18	to	to	PART
dpc-4876	95	19	compare	compare	VERB
dpc-4876	95	20	the	the	DET
dpc-4876	95	21	difference	difference	NOUN
dpc-4876	95	22	in	in	ADP
dpc-4876	95	23	medians	median	NOUN
dpc-4876	95	24	,	,	PUNCT
dpc-4876	95	25	and	and	CCONJ
dpc-4876	95	26	the	the	DET
dpc-4876	95	27	post	post	ADJ
dpc-4876	95	28	-	-	ADJ
dpc-4876	95	29	hoc	hoc	ADJ
dpc-4876	95	30	test	test	NOUN
dpc-4876	95	31	with	with	ADP
dpc-4876	95	32	bonferroni	bonferroni	NOUN
dpc-4876	95	33	correction	correction	NOUN
dpc-4876	95	34	was	be	AUX
dpc-4876	95	35	used	use	VERB
dpc-4876	95	36	for	for	ADP
dpc-4876	95	37	pairwise	pairwise	NOUN
dpc-4876	95	38	comparisons	comparison	NOUN
dpc-4876	95	39	.	.	PUNCT
dpc-4876	96	1	the	the	DET
dpc-4876	96	2	clinical	clinical	ADJ
dpc-4876	96	3	and	and	CCONJ
dpc-4876	96	4	demographic	demographic	ADJ
dpc-4876	96	5	factors	factor	NOUN
dpc-4876	96	6	with	with	ADP
dpc-4876	96	7	proven	prove	VERB
dpc-4876	96	8	statistical	statistical	ADJ
dpc-4876	96	9	significance	significance	NOUN
dpc-4876	96	10	from	from	ADP
dpc-4876	96	11	the	the	DET
dpc-4876	96	12	univariate	univariate	ADJ
dpc-4876	96	13	analyses	analysis	NOUN
dpc-4876	96	14	were	be	AUX
dpc-4876	96	15	further	far	ADV
dpc-4876	96	16	included	include	VERB
dpc-4876	96	17	in	in	ADP
dpc-4876	96	18	the	the	DET
dpc-4876	96	19	multivariate	multivariate	NOUN
dpc-4876	96	20	logistic	logistic	ADJ
dpc-4876	96	21	regression	regression	NOUN
dpc-4876	96	22	models	model	NOUN
dpc-4876	96	23	(	(	PUNCT
dpc-4876	96	24	odds	odd	NOUN
dpc-4876	96	25	ratio	ratio	NOUN
dpc-4876	96	26	(	(	PUNCT
dpc-4876	96	27	or	or	CCONJ
dpc-4876	96	28	)	)	PUNCT
dpc-4876	96	29	,	,	PUNCT
dpc-4876	96	30	95	95	NUM
dpc-4876	96	31	%	%	NOUN
dpc-4876	96	32	confidence	confidence	NOUN
dpc-4876	96	33	(	(	PUNCT
dpc-4876	96	34	ci	ci	NOUN
dpc-4876	96	35	)	)	PUNCT
dpc-4876	96	36	)	)	PUNCT
dpc-4876	96	37	.	.	PUNCT
dpc-4876	97	1	spearman	spearman	NOUN
dpc-4876	97	2	’s	’s	PART
dpc-4876	97	3	rank	rank	NOUN
dpc-4876	97	4	correlation	correlation	NOUN
dpc-4876	97	5	analysis	analysis	NOUN
dpc-4876	97	6	was	be	AUX
dpc-4876	97	7	used	use	VERB
dpc-4876	97	8	to	to	PART
dpc-4876	97	9	test	test	VERB
dpc-4876	97	10	the	the	DET
dpc-4876	97	11	association	association	NOUN
dpc-4876	97	12	between	between	ADP
dpc-4876	97	13	variables	variable	NOUN
dpc-4876	97	14	.	.	PUNCT
dpc-4876	98	1	a	a	DET
dpc-4876	98	2	p	p	NOUN
dpc-4876	98	3	-	-	PUNCT
dpc-4876	98	4	value	value	NOUN
dpc-4876	98	5	of	of	ADP
dpc-4876	98	6	≤	≤	NUM
dpc-4876	98	7	0.05	0.05	NUM
dpc-4876	98	8	was	be	AUX
dpc-4876	98	9	considered	consider	VERB
dpc-4876	98	10	statistically	statistically	ADV
dpc-4876	98	11	significant	significant	ADJ
dpc-4876	98	12	.	.	PUNCT
dpc-4876	99	1	results	result	VERB
dpc-4876	99	2	the	the	DET
dpc-4876	99	3	study	study	NOUN
dpc-4876	99	4	was	be	AUX
dpc-4876	99	5	conducted	conduct	VERB
dpc-4876	99	6	on	on	ADP
dpc-4876	99	7	60	60	NUM
dpc-4876	99	8	cases	case	NOUN
dpc-4876	99	9	:	:	PUNCT
dpc-4876	99	10	21	21	NUM
dpc-4876	99	11	control	control	NOUN
dpc-4876	99	12	and	and	CCONJ
dpc-4876	99	13	39	39	NUM
dpc-4876	99	14	pgh	pgh	NOUN
dpc-4876	99	15	patients	patient	NOUN
dpc-4876	99	16	.	.	PUNCT
dpc-4876	100	1	the	the	DET
dpc-4876	100	2	mean	mean	ADJ
dpc-4876	100	3	age	age	NOUN
dpc-4876	100	4	was	be	AUX
dpc-4876	100	5	27.03±	27.03±	NUM
dpc-4876	100	6	3.7	3.7	NUM
dpc-4876	100	7	years	year	NOUN
dpc-4876	100	8	in	in	ADP
dpc-4876	100	9	the	the	DET
dpc-4876	100	10	control	control	NOUN
dpc-4876	100	11	group	group	NOUN
dpc-4876	100	12	and	and	CCONJ
dpc-4876	100	13	27.1±	27.1±	NOUN
dpc-4876	100	14	1.7	1.7	NUM
dpc-4876	100	15	years	year	NOUN
dpc-4876	100	16	in	in	ADP
dpc-4876	100	17	pgh	pgh	PROPN
dpc-4876	100	18	patients	patient	NOUN
dpc-4876	100	19	.	.	PUNCT
dpc-4876	101	1	females	female	NOUN
dpc-4876	101	2	constituted	constitute	VERB
dpc-4876	101	3	66.7	66.7	NUM
dpc-4876	101	4	%	%	NOUN
dpc-4876	101	5	and	and	CCONJ
dpc-4876	101	6	82.1	82.1	NUM
dpc-4876	101	7	%	%	NOUN
dpc-4876	101	8	in	in	ADP
dpc-4876	101	9	the	the	DET
dpc-4876	101	10	control	control	NOUN
dpc-4876	101	11	and	and	CCONJ
dpc-4876	101	12	pgh	pgh	PROPN
dpc-4876	101	13	groups	group	NOUN
dpc-4876	101	14	,	,	PUNCT
dpc-4876	101	15	respectively	respectively	ADV
dpc-4876	101	16	.	.	PUNCT
dpc-4876	102	1	there	there	PRON
dpc-4876	102	2	was	be	VERB
dpc-4876	102	3	no	no	DET
dpc-4876	102	4	statistical	statistical	ADJ
dpc-4876	102	5	significance	significance	NOUN
dpc-4876	102	6	as	as	SCONJ
dpc-4876	102	7	regards	regard	VERB
dpc-4876	102	8	age	age	NOUN
dpc-4876	102	9	,	,	PUNCT
dpc-4876	102	10	sex	sex	NOUN
dpc-4876	102	11	,	,	PUNCT
dpc-4876	102	12	or	or	CCONJ
dpc-4876	102	13	hemoglobin	hemoglobin	NOUN
dpc-4876	102	14	level	level	NOUN
dpc-4876	102	15	,	,	PUNCT
dpc-4876	102	16	as	as	SCONJ
dpc-4876	102	17	shown	show	VERB
dpc-4876	102	18	in	in	ADP
dpc-4876	102	19	table	table	NOUN
dpc-4876	102	20	1	1	NUM
dpc-4876	102	21	.	.	PUNCT
dpc-4876	103	1	the	the	DET
dpc-4876	103	2	history	history	NOUN
dpc-4876	103	3	of	of	ADP
dpc-4876	103	4	age	age	NOUN
dpc-4876	103	5	at	at	ADP
dpc-4876	103	6	onset	onset	NOUN
dpc-4876	103	7	in	in	ADP
dpc-4876	103	8	the	the	DET
dpc-4876	103	9	pgh	pgh	PROPN
dpc-4876	103	10	group	group	NOUN
dpc-4876	103	11	was	be	AUX
dpc-4876	103	12	19.77±	19.77±	NUM
dpc-4876	103	13	3.5	3.5	NUM
dpc-4876	103	14	years	year	NOUN
dpc-4876	103	15	old	old	ADJ
dpc-4876	103	16	,	,	PUNCT
dpc-4876	103	17	with	with	ADP
dpc-4876	103	18	the	the	DET
dpc-4876	103	19	mean	mean	ADJ
dpc-4876	103	20	disease	disease	NOUN
dpc-4876	103	21	duration	duration	NOUN
dpc-4876	103	22	of	of	ADP
dpc-4876	103	23	7.28±	7.28±	NUM
dpc-4876	103	24	2.8	2.8	NUM
dpc-4876	103	25	years	year	NOUN
dpc-4876	103	26	.	.	PUNCT
dpc-4876	104	1	family	family	NOUN
dpc-4876	104	2	history	history	NOUN
dpc-4876	104	3	of	of	ADP
dpc-4876	104	4	pgh	pgh	PROPN
dpc-4876	104	5	was	be	AUX
dpc-4876	104	6	positive	positive	ADJ
dpc-4876	104	7	in	in	ADP
dpc-4876	104	8	89.7	89.7	NUM
dpc-4876	104	9	%	%	NOUN
dpc-4876	104	10	(	(	PUNCT
dpc-4876	104	11	35/39	35/39	NUM
dpc-4876	104	12	)	)	PUNCT
dpc-4876	104	13	.	.	PUNCT
dpc-4876	105	1	about	about	ADV
dpc-4876	105	2	3/4	3/4	NUM
dpc-4876	105	3	of	of	ADP
dpc-4876	105	4	pgh	pgh	PROPN
dpc-4876	105	5	patients	patient	NOUN
dpc-4876	105	6	(	(	PUNCT
dpc-4876	105	7	74.3	74.3	NUM
dpc-4876	105	8	%	%	NOUN
dpc-4876	105	9	,	,	PUNCT
dpc-4876	105	10	29/39	29/39	NUM
dpc-4876	105	11	)	)	PUNCT
dpc-4876	105	12	had	have	VERB
dpc-4876	105	13	severe	severe	ADJ
dpc-4876	105	14	disease	disease	NOUN
dpc-4876	105	15	,	,	PUNCT
dpc-4876	105	16	with	with	ADP
dpc-4876	105	17	the	the	DET
dpc-4876	105	18	majority	majority	NOUN
dpc-4876	105	19	of	of	ADP
dpc-4876	105	20	patients	patient	NOUN
dpc-4876	105	21	(	(	PUNCT
dpc-4876	105	22	84.6	84.6	NUM
dpc-4876	105	23	%	%	NOUN
dpc-4876	105	24	,	,	PUNCT
dpc-4876	105	25	33/39	33/39	NUM
dpc-4876	105	26	)	)	PUNCT
dpc-4876	105	27	having	have	VERB
dpc-4876	105	28	≥	≥	NOUN
dpc-4876	105	29	four	four	NUM
dpc-4876	105	30	affected	affected	ADJ
dpc-4876	105	31	sites	site	NOUN
dpc-4876	105	32	with	with	ADP
dpc-4876	105	33	pgh	pgh	PROPN
dpc-4876	105	34	.	.	PUNCT
dpc-4876	106	1	other	other	ADJ
dpc-4876	106	2	clinical	clinical	ADJ
dpc-4876	106	3	characteristics	characteristic	NOUN
dpc-4876	106	4	are	be	AUX
dpc-4876	106	5	shown	show	VERB
dpc-4876	106	6	in	in	ADP
dpc-4876	106	7	table	table	NOUN
dpc-4876	106	8	2	2	NUM
dpc-4876	106	9	.	.	PUNCT
dpc-4876	107	1	there	there	PRON
dpc-4876	107	2	was	be	VERB
dpc-4876	107	3	a	a	DET
dpc-4876	107	4	statistically	statistically	ADV
dpc-4876	107	5	significant	significant	ADJ
dpc-4876	107	6	difference	difference	NOUN
dpc-4876	107	7	between	between	ADP
dpc-4876	107	8	the	the	DET
dpc-4876	107	9	two	two	NUM
dpc-4876	107	10	groups	group	NOUN
dpc-4876	107	11	as	as	SCONJ
dpc-4876	107	12	regards	regard	VERB
dpc-4876	107	13	expression	expression	NOUN
dpc-4876	107	14	levels	level	NOUN
dpc-4876	107	15	of	of	ADP
dpc-4876	107	16	the	the	DET
dpc-4876	107	17	lc3	lc3	NOUN
dpc-4876	107	18	gene	gene	NOUN
dpc-4876	107	19	by	by	ADP
dpc-4876	107	20	pcr	pcr	PROPN
dpc-4876	107	21	(	(	PUNCT
dpc-4876	107	22	p<0.001	p<0.001	PROPN
dpc-4876	107	23	)	)	PUNCT
dpc-4876	107	24	.	.	PUNCT
dpc-4876	108	1	however	however	ADV
dpc-4876	108	2	,	,	PUNCT
dpc-4876	108	3	there	there	PRON
dpc-4876	108	4	was	be	VERB
dpc-4876	108	5	no	no	DET
dpc-4876	108	6	4	4	NUM
dpc-4876	108	7	original	original	ADJ
dpc-4876	108	8	article	article	NOUN
dpc-4876	108	9	|	|	ADV
dpc-4876	108	10	dermatol	dermatol	ADJ
dpc-4876	108	11	pract	pract	NOUN
dpc-4876	108	12	concept	concept	NOUN
dpc-4876	108	13	.	.	PUNCT
dpc-4876	109	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	109	2	patients	patient	NOUN
dpc-4876	109	3	according	accord	VERB
dpc-4876	109	4	to	to	ADP
dpc-4876	109	5	disease	disease	NOUN
dpc-4876	109	6	duration	duration	NOUN
dpc-4876	109	7	(	(	PUNCT
dpc-4876	109	8	≤7	≤7	VERB
dpc-4876	109	9	vs	vs	ADP
dpc-4876	109	10	>	>	ADP
dpc-4876	109	11	7	7	NUM
dpc-4876	109	12	years	year	NOUN
dpc-4876	109	13	)	)	PUNCT
dpc-4876	109	14	showed	show	VERB
dpc-4876	109	15	a	a	DET
dpc-4876	109	16	statistically	statistically	ADV
dpc-4876	109	17	significant	significant	ADJ
dpc-4876	109	18	difference	difference	NOUN
dpc-4876	109	19	in	in	ADP
dpc-4876	109	20	both	both	PRON
dpc-4876	109	21	lc3	lc3	NOUN
dpc-4876	109	22	gene	gene	NOUN
dpc-4876	109	23	level	level	NOUN
dpc-4876	109	24	by	by	ADP
dpc-4876	109	25	pcr	pcr	PROPN
dpc-4876	109	26	(	(	PUNCT
dpc-4876	109	27	p=0.016	p=0.016	NUM
dpc-4876	109	28	)	)	PUNCT
dpc-4876	109	29	and	and	CCONJ
dpc-4876	109	30	lc3	lc3	VERB
dpc-4876	109	31	concentration	concentration	NOUN
dpc-4876	109	32	by	by	ADP
dpc-4876	109	33	elisa	elisa	PROPN
dpc-4876	109	34	(	(	PUNCT
dpc-4876	109	35	p=0.024	p=0.024	NOUN
dpc-4876	109	36	)	)	PUNCT
dpc-4876	109	37	,	,	PUNCT
dpc-4876	109	38	as	as	SCONJ
dpc-4876	109	39	shown	show	VERB
dpc-4876	109	40	in	in	ADP
dpc-4876	109	41	table	table	NOUN
dpc-4876	109	42	3	3	NUM
dpc-4876	109	43	.	.	PUNCT
dpc-4876	110	1	however	however	ADV
dpc-4876	110	2	,	,	PUNCT
dpc-4876	110	3	the	the	DET
dpc-4876	110	4	classification	classification	NOUN
dpc-4876	110	5	of	of	ADP
dpc-4876	110	6	pgh	pgh	PROPN
dpc-4876	110	7	patients	patient	NOUN
dpc-4876	110	8	according	accord	VERB
dpc-4876	110	9	to	to	ADP
dpc-4876	110	10	disease	disease	NOUN
dpc-4876	110	11	severity	severity	NOUN
dpc-4876	110	12	showed	show	VERB
dpc-4876	110	13	no	no	DET
dpc-4876	110	14	statistically	statistically	ADV
dpc-4876	110	15	significant	significant	ADJ
dpc-4876	110	16	difference	difference	NOUN
dpc-4876	110	17	between	between	ADP
dpc-4876	110	18	both	both	DET
dpc-4876	110	19	lc3	lc3	NOUN
dpc-4876	110	20	gene	gene	NOUN
dpc-4876	110	21	level	level	NOUN
dpc-4876	110	22	by	by	ADP
dpc-4876	110	23	pcr	pcr	ADJ
dpc-4876	110	24	and	and	CCONJ
dpc-4876	110	25	lc3	lc3	NOUN
dpc-4876	110	26	concentration	concentration	NOUN
dpc-4876	110	27	by	by	ADP
dpc-4876	110	28	elisa	elisa	NOUN
dpc-4876	110	29	,	,	PUNCT
dpc-4876	110	30	as	as	SCONJ
dpc-4876	110	31	shown	show	VERB
dpc-4876	110	32	in	in	ADP
dpc-4876	110	33	table	table	NOUN
dpc-4876	110	34	3	3	NUM
dpc-4876	110	35	.	.	PUNCT
dpc-4876	111	1	there	there	PRON
dpc-4876	111	2	was	be	VERB
dpc-4876	111	3	a	a	DET
dpc-4876	111	4	positive	positive	ADJ
dpc-4876	111	5	significant	significant	ADJ
dpc-4876	111	6	correlation	correlation	NOUN
dpc-4876	111	7	between	between	ADP
dpc-4876	111	8	lc3	lc3	NOUN
dpc-4876	111	9	concentration	concentration	NOUN
dpc-4876	111	10	and	and	CCONJ
dpc-4876	111	11	lc3	lc3	NOUN
dpc-4876	111	12	gene	gene	NOUN
dpc-4876	111	13	expression	expression	NOUN
dpc-4876	111	14	in	in	ADP
dpc-4876	111	15	control	control	NOUN
dpc-4876	111	16	(	(	PUNCT
dpc-4876	111	17	r=0.867	r=0.867	X
dpc-4876	111	18	,	,	PUNCT
dpc-4876	111	19	p<0.001	p<0.001	PROPN
dpc-4876	111	20	)	)	PUNCT
dpc-4876	111	21	,	,	PUNCT
dpc-4876	111	22	as	as	SCONJ
dpc-4876	111	23	shown	show	VERB
dpc-4876	111	24	in	in	ADP
dpc-4876	111	25	figure	figure	NOUN
dpc-4876	111	26	1	1	NUM
dpc-4876	111	27	,	,	PUNCT
dpc-4876	111	28	and	and	CCONJ
dpc-4876	111	29	in	in	ADP
dpc-4876	111	30	pgh	pgh	PROPN
dpc-4876	111	31	patients	patient	NOUN
dpc-4876	111	32	(	(	PUNCT
dpc-4876	111	33	r=0.954	r=0.954	NOUN
dpc-4876	111	34	,	,	PUNCT
dpc-4876	111	35	p=	p=	X
dpc-4876	111	36	<	<	X
dpc-4876	111	37	0.001	0.001	NUM
dpc-4876	111	38	)	)	PUNCT
dpc-4876	111	39	,	,	PUNCT
dpc-4876	111	40	as	as	SCONJ
dpc-4876	111	41	shown	show	VERB
dpc-4876	111	42	in	in	ADP
dpc-4876	111	43	figure	figure	NOUN
dpc-4876	111	44	2	2	NUM
dpc-4876	111	45	.	.	PUNCT
dpc-4876	112	1	there	there	PRON
dpc-4876	112	2	was	be	VERB
dpc-4876	112	3	a	a	DET
dpc-4876	112	4	positive	positive	ADJ
dpc-4876	112	5	correlation	correlation	NOUN
dpc-4876	112	6	between	between	ADP
dpc-4876	112	7	lc3	lc3	NOUN
dpc-4876	112	8	gene	gene	NOUN
dpc-4876	112	9	expression	expression	NOUN
dpc-4876	112	10	and	and	CCONJ
dpc-4876	112	11	age	age	NOUN
dpc-4876	112	12	at	at	ADP
dpc-4876	112	13	onset	onset	NOUN
dpc-4876	112	14	of	of	ADP
dpc-4876	112	15	pgh	pgh	PROPN
dpc-4876	112	16	(	(	PUNCT
dpc-4876	112	17	r=0.321	r=0.321	X
dpc-4876	112	18	,	,	PUNCT
dpc-4876	112	19	p=0.023	p=0.023	NUM
dpc-4876	112	20	)	)	PUNCT
dpc-4876	112	21	,	,	PUNCT
dpc-4876	112	22	as	as	SCONJ
dpc-4876	112	23	shown	show	VERB
dpc-4876	112	24	in	in	ADP
dpc-4876	112	25	figure	figure	NOUN
dpc-4876	112	26	3	3	NUM
dpc-4876	112	27	.	.	PUNCT
dpc-4876	113	1	also	also	ADV
dpc-4876	113	2	,	,	PUNCT
dpc-4876	113	3	there	there	PRON
dpc-4876	113	4	was	be	VERB
dpc-4876	113	5	a	a	DET
dpc-4876	113	6	positive	positive	ADJ
dpc-4876	113	7	significant	significant	ADJ
dpc-4876	113	8	correlation	correlation	NOUN
dpc-4876	113	9	between	between	ADP
dpc-4876	113	10	lc3	lc3	NOUN
dpc-4876	113	11	concentration	concentration	NOUN
dpc-4876	113	12	and	and	CCONJ
dpc-4876	113	13	age	age	NOUN
dpc-4876	113	14	at	at	ADP
dpc-4876	113	15	onset	onset	NOUN
dpc-4876	113	16	of	of	ADP
dpc-4876	113	17	pgh	pgh	PROPN
dpc-4876	113	18	(	(	PUNCT
dpc-4876	113	19	r=0.364	r=0.364	PROPN
dpc-4876	113	20	,	,	PUNCT
dpc-4876	113	21	p=0.011	p=0.011	X
dpc-4876	113	22	)	)	PUNCT
dpc-4876	113	23	,	,	PUNCT
dpc-4876	113	24	as	as	SCONJ
dpc-4876	113	25	shown	show	VERB
dpc-4876	113	26	in	in	ADP
dpc-4876	113	27	figure	figure	NOUN
dpc-4876	113	28	4	4	NUM
dpc-4876	113	29	.	.	PUNCT
dpc-4876	114	1	in	in	ADP
dpc-4876	114	2	addition	addition	NOUN
dpc-4876	114	3	,	,	PUNCT
dpc-4876	114	4	there	there	PRON
dpc-4876	114	5	was	be	VERB
dpc-4876	114	6	a	a	DET
dpc-4876	114	7	negative	negative	ADJ
dpc-4876	114	8	correlation	correlation	NOUN
dpc-4876	114	9	between	between	ADP
dpc-4876	114	10	lc3	lc3	NOUN
dpc-4876	114	11	gene	gene	NOUN
dpc-4876	114	12	expression	expression	NOUN
dpc-4876	114	13	and	and	CCONJ
dpc-4876	114	14	disease	disease	NOUN
dpc-4876	114	15	duration	duration	NOUN
dpc-4876	114	16	(	(	PUNCT
dpc-4876	114	17	r=-0.393	r=-0.393	NOUN
dpc-4876	114	18	,	,	PUNCT
dpc-4876	114	19	p=0.007	p=0.007	ADP
dpc-4876	114	20	)	)	PUNCT
dpc-4876	114	21	,	,	PUNCT
dpc-4876	114	22	as	as	SCONJ
dpc-4876	114	23	shown	show	VERB
dpc-4876	114	24	in	in	ADP
dpc-4876	114	25	figure	figure	NOUN
dpc-4876	114	26	5	5	NUM
dpc-4876	114	27	,	,	PUNCT
dpc-4876	114	28	and	and	CCONJ
dpc-4876	114	29	a	a	DET
dpc-4876	114	30	negative	negative	ADJ
dpc-4876	114	31	correlation	correlation	NOUN
dpc-4876	114	32	between	between	ADP
dpc-4876	114	33	lc3	lc3	NOUN
dpc-4876	114	34	concentration	concentration	NOUN
dpc-4876	114	35	and	and	CCONJ
dpc-4876	114	36	disease	disease	NOUN
dpc-4876	114	37	duration	duration	NOUN
dpc-4876	114	38	(	(	PUNCT
dpc-4876	114	39	r=-0.382	r=-0.382	NOUN
dpc-4876	114	40	,	,	PUNCT
dpc-4876	114	41	p=0.008	p=0.008	NOUN
dpc-4876	114	42	)	)	PUNCT
dpc-4876	114	43	,	,	PUNCT
dpc-4876	114	44	as	as	SCONJ
dpc-4876	114	45	shown	show	VERB
dpc-4876	114	46	in	in	ADP
dpc-4876	114	47	figure	figure	NOUN
dpc-4876	114	48	6	6	NUM
dpc-4876	114	49	.	.	PUNCT
dpc-4876	115	1	a	a	DET
dpc-4876	115	2	multivariate	multivariate	NOUN
dpc-4876	115	3	logistic	logistic	ADJ
dpc-4876	115	4	regression	regression	NOUN
dpc-4876	115	5	analysis	analysis	NOUN
dpc-4876	115	6	for	for	ADP
dpc-4876	115	7	pgh	pgh	NOUN
dpc-4876	115	8	predictors	predictor	NOUN
dpc-4876	115	9	using	use	VERB
dpc-4876	115	10	age	age	NOUN
dpc-4876	115	11	,	,	PUNCT
dpc-4876	115	12	sex	sex	NOUN
dpc-4876	115	13	(	(	PUNCT
dpc-4876	115	14	female	female	NOUN
dpc-4876	115	15	)	)	PUNCT
dpc-4876	115	16	,	,	PUNCT
dpc-4876	115	17	hemoglobin	hemoglobin	NOUN
dpc-4876	115	18	level	level	NOUN
dpc-4876	115	19	,	,	PUNCT
dpc-4876	115	20	lc3	lc3	NOUN
dpc-4876	115	21	concentration	concentration	NOUN
dpc-4876	115	22	,	,	PUNCT
dpc-4876	115	23	and	and	CCONJ
dpc-4876	115	24	lc3	lc3	NOUN
dpc-4876	115	25	gene	gene	NOUN
dpc-4876	115	26	expression	expression	NOUN
dpc-4876	115	27	was	be	AUX
dpc-4876	115	28	done	do	VERB
dpc-4876	115	29	;	;	PUNCT
dpc-4876	115	30	after	after	ADP
dpc-4876	115	31	adjusting	adjust	VERB
dpc-4876	115	32	for	for	ADP
dpc-4876	115	33	all	all	DET
dpc-4876	115	34	factors	factor	NOUN
dpc-4876	115	35	,	,	PUNCT
dpc-4876	115	36	the	the	DET
dpc-4876	115	37	only	only	ADJ
dpc-4876	115	38	predictor	predictor	NOUN
dpc-4876	115	39	of	of	ADP
dpc-4876	115	40	pgh	pgh	PROPN
dpc-4876	115	41	was	be	AUX
dpc-4876	115	42	lc3	lc3	NOUN
dpc-4876	115	43	gene	gene	NOUN
dpc-4876	115	44	expression	expression	NOUN
dpc-4876	115	45	.	.	PUNCT
dpc-4876	116	1	in	in	ADP
dpc-4876	116	2	other	other	ADJ
dpc-4876	116	3	words	word	NOUN
dpc-4876	116	4	,	,	PUNCT
dpc-4876	116	5	with	with	ADP
dpc-4876	116	6	a	a	DET
dpc-4876	116	7	one	one	NUM
dpc-4876	116	8	-	-	PUNCT
dpc-4876	116	9	point	point	NOUN
dpc-4876	116	10	increase	increase	NOUN
dpc-4876	116	11	in	in	ADP
dpc-4876	116	12	the	the	DET
dpc-4876	116	13	lc3	lc3	NOUN
dpc-4876	116	14	expression	expression	NOUN
dpc-4876	116	15	,	,	PUNCT
dpc-4876	116	16	there	there	PRON
dpc-4876	116	17	was	be	VERB
dpc-4876	116	18	a	a	DET
dpc-4876	116	19	six	six	NUM
dpc-4876	116	20	-	-	PUNCT
dpc-4876	116	21	time	time	NOUN
dpc-4876	116	22	increase	increase	NOUN
dpc-4876	116	23	in	in	ADP
dpc-4876	116	24	the	the	DET
dpc-4876	116	25	risk	risk	NOUN
dpc-4876	116	26	of	of	ADP
dpc-4876	116	27	having	have	VERB
dpc-4876	116	28	pgh	pgh	PROPN
dpc-4876	116	29	,	,	PUNCT
dpc-4876	116	30	as	as	SCONJ
dpc-4876	116	31	shown	show	VERB
dpc-4876	116	32	in	in	ADP
dpc-4876	116	33	table	table	NOUN
dpc-4876	116	34	4	4	NUM
dpc-4876	116	35	.	.	PUNCT
dpc-4876	117	1	discussion	discussion	NOUN
dpc-4876	117	2	premature	premature	ADJ
dpc-4876	117	3	graying	graying	NOUN
dpc-4876	117	4	of	of	ADP
dpc-4876	117	5	hair	hair	NOUN
dpc-4876	117	6	is	be	AUX
dpc-4876	117	7	a	a	DET
dpc-4876	117	8	very	very	ADV
dpc-4876	117	9	common	common	ADJ
dpc-4876	117	10	disorder	disorder	NOUN
dpc-4876	117	11	.	.	PUNCT
dpc-4876	118	1	the	the	DET
dpc-4876	118	2	prevalence	prevalence	NOUN
dpc-4876	118	3	of	of	ADP
dpc-4876	118	4	pgh	pgh	PROPN
dpc-4876	118	5	varies	vary	VERB
dpc-4876	118	6	among	among	ADP
dpc-4876	118	7	different	different	ADJ
dpc-4876	118	8	clinical	clinical	ADJ
dpc-4876	118	9	studies	study	NOUN
dpc-4876	118	10	,	,	PUNCT
dpc-4876	118	11	from	from	ADP
dpc-4876	118	12	27.3	27.3	NUM
dpc-4876	118	13	%	%	NOUN
dpc-4876	118	14	[	[	X
dpc-4876	118	15	16	16	NUM
dpc-4876	118	16	]	]	PUNCT
dpc-4876	118	17	up	up	ADP
dpc-4876	118	18	to	to	PART
dpc-4876	118	19	69	69	NUM
dpc-4876	118	20	%	%	NOUN
dpc-4876	119	1	[	[	X
dpc-4876	119	2	17	17	NUM
dpc-4876	119	3	]	]	PUNCT
dpc-4876	119	4	.	.	PUNCT
dpc-4876	120	1	the	the	DET
dpc-4876	120	2	etiology	etiology	NOUN
dpc-4876	120	3	of	of	ADP
dpc-4876	120	4	pgh	pgh	PROPN
dpc-4876	120	5	is	be	AUX
dpc-4876	120	6	multifactorial	multifactorial	ADJ
dpc-4876	120	7	,	,	PUNCT
dpc-4876	120	8	with	with	ADP
dpc-4876	120	9	the	the	DET
dpc-4876	120	10	genetically	genetically	ADV
dpc-4876	120	11	determined	determine	VERB
dpc-4876	120	12	,	,	PUNCT
dpc-4876	120	13	age	age	NOUN
dpc-4876	120	14	-	-	PUNCT
dpc-4876	120	15	related	relate	VERB
dpc-4876	120	16	exhaustion	exhaustion	NOUN
dpc-4876	120	17	of	of	ADP
dpc-4876	120	18	hair	hair	NOUN
dpc-4876	120	19	follicle	follicle	NOUN
dpc-4876	120	20	pigmentary	pigmentary	NOUN
dpc-4876	120	21	capacity	capacity	NOUN
dpc-4876	120	22	as	as	ADP
dpc-4876	120	23	the	the	DET
dpc-4876	120	24	main	main	ADJ
dpc-4876	120	25	cause	cause	NOUN
dpc-4876	120	26	.	.	PUNCT
dpc-4876	121	1	this	this	PRON
dpc-4876	121	2	may	may	AUX
dpc-4876	121	3	be	be	AUX
dpc-4876	121	4	mediated	mediate	VERB
dpc-4876	121	5	through	through	ADP
dpc-4876	121	6	increased	increase	VERB
dpc-4876	121	7	reactive	reactive	ADJ
dpc-4876	121	8	oxygen	oxygen	NOUN
dpc-4876	121	9	species	specie	NOUN
dpc-4876	121	10	and	and	CCONJ
dpc-4876	121	11	dysregulation	dysregulation	NOUN
dpc-4876	121	12	of	of	ADP
dpc-4876	121	13	the	the	DET
dpc-4876	121	14	anti	anti	ADJ
dpc-4876	121	15	-	-	ADJ
dpc-4876	121	16	oxidant	oxidant	ADJ
dpc-4876	121	17	capacity	capacity	NOUN
dpc-4876	121	18	,	,	PUNCT
dpc-4876	121	19	which	which	PRON
dpc-4876	121	20	lead	lead	VERB
dpc-4876	121	21	to	to	ADP
dpc-4876	121	22	melanocyte	melanocyte	NOUN
dpc-4876	121	23	dna	dna	PROPN
dpc-4876	121	24	damage	damage	NOUN
dpc-4876	121	25	and	and	CCONJ
dpc-4876	121	26	accumulation	accumulation	NOUN
dpc-4876	121	27	of	of	ADP
dpc-4876	121	28	gene	gene	NOUN
dpc-4876	121	29	mutations	mutation	NOUN
dpc-4876	121	30	with	with	ADP
dpc-4876	121	31	aging	age	VERB
dpc-4876	121	32	[	[	X
dpc-4876	121	33	5	5	NUM
dpc-4876	121	34	]	]	PUNCT
dpc-4876	121	35	.	.	PUNCT
dpc-4876	122	1	autophagy	autophagy	PROPN
dpc-4876	122	2	plays	play	VERB
dpc-4876	122	3	an	an	DET
dpc-4876	122	4	important	important	ADJ
dpc-4876	122	5	role	role	NOUN
dpc-4876	122	6	in	in	ADP
dpc-4876	122	7	melanogenesis	melanogenesis	NOUN
dpc-4876	122	8	and	and	CCONJ
dpc-4876	122	9	melanosome	melanosome	NOUN
dpc-4876	122	10	transfer	transfer	NOUN
dpc-4876	122	11	[	[	NOUN
dpc-4876	122	12	12	12	NUM
dpc-4876	122	13	]	]	PUNCT
dpc-4876	122	14	table	table	NOUN
dpc-4876	122	15	1	1	NUM
dpc-4876	122	16	.	.	PUNCT
dpc-4876	122	17	basic	basic	ADJ
dpc-4876	122	18	clinical	clinical	ADJ
dpc-4876	122	19	and	and	CCONJ
dpc-4876	122	20	laboratory	laboratory	NOUN
dpc-4876	122	21	characteristics	characteristic	NOUN
dpc-4876	122	22	of	of	ADP
dpc-4876	122	23	pgh	pgh	PROPN
dpc-4876	122	24	patients	patient	NOUN
dpc-4876	122	25	(	(	PUNCT
dpc-4876	122	26	n=39	n=39	X
dpc-4876	122	27	)	)	PUNCT
dpc-4876	122	28	and	and	CCONJ
dpc-4876	122	29	control	control	NOUN
dpc-4876	122	30	(	(	PUNCT
dpc-4876	122	31	n=21	n=21	NOUN
dpc-4876	122	32	)	)	PUNCT
dpc-4876	122	33	group	group	NOUN
dpc-4876	122	34	.	.	PUNCT
dpc-4876	123	1	parameter	parameter	PROPN
dpc-4876	123	2	group	group	PROPN
dpc-4876	123	3	1	1	NUM
dpc-4876	123	4	control	control	NOUN
dpc-4876	123	5	(	(	PUNCT
dpc-4876	123	6	n	n	NOUN
dpc-4876	123	7	=	=	SYM
dpc-4876	123	8	21	21	NUM
dpc-4876	123	9	)	)	PUNCT
dpc-4876	123	10	group	group	NOUN
dpc-4876	123	11	2	2	NUM
dpc-4876	123	12	cases	case	NOUN
dpc-4876	123	13	(	(	PUNCT
dpc-4876	123	14	n	n	NOUN
dpc-4876	123	15	=	=	SYM
dpc-4876	123	16	39	39	NUM
dpc-4876	123	17	)	)	PUNCT
dpc-4876	123	18	p	p	X
dpc-4876	123	19	-	-	PUNCT
dpc-4876	123	20	value	value	NOUN
dpc-4876	123	21	age	age	NOUN
dpc-4876	123	22	(	(	PUNCT
dpc-4876	123	23	years	year	NOUN
dpc-4876	123	24	)	)	PUNCT
dpc-4876	123	25	27.10	27.10	NUM
dpc-4876	123	26	±	±	NUM
dpc-4876	123	27	1.7	1.7	NUM
dpc-4876	123	28	27.03	27.03	NUM
dpc-4876	123	29	±	±	NUM
dpc-4876	123	30	3.7	3.7	NUM
dpc-4876	123	31	0.922	0.922	NUM
dpc-4876	123	32	*	*	NOUN
dpc-4876	123	33	sex	sex	NOUN
dpc-4876	123	34	•	•	NOUN
dpc-4876	123	35	male	male	ADJ
dpc-4876	123	36	•	•	NOUN
dpc-4876	123	37	female	female	NOUN
dpc-4876	123	38	7	7	NUM
dpc-4876	123	39	(	(	PUNCT
dpc-4876	123	40	33.3	33.3	NUM
dpc-4876	123	41	%	%	NOUN
dpc-4876	123	42	)	)	PUNCT
dpc-4876	123	43	14	14	NUM
dpc-4876	123	44	(	(	PUNCT
dpc-4876	123	45	66.7	66.7	NUM
dpc-4876	123	46	%	%	NOUN
dpc-4876	123	47	)	)	PUNCT
dpc-4876	123	48	7	7	NUM
dpc-4876	123	49	(	(	PUNCT
dpc-4876	123	50	17.9	17.9	NUM
dpc-4876	123	51	%	%	NOUN
dpc-4876	123	52	)	)	PUNCT
dpc-4876	123	53	32	32	NUM
dpc-4876	123	54	(	(	PUNCT
dpc-4876	123	55	82.1	82.1	NUM
dpc-4876	123	56	%	%	NOUN
dpc-4876	123	57	)	)	PUNCT
dpc-4876	123	58	0.179	0.179	NUM
dpc-4876	123	59	*	*	PUNCT
dpc-4876	123	60	*	*	NOUN
dpc-4876	123	61	hemoglobin	hemoglobin	NOUN
dpc-4876	123	62	(	(	PUNCT
dpc-4876	123	63	g	g	PROPN
dpc-4876	123	64	/	/	SYM
dpc-4876	123	65	dl	dl	NOUN
dpc-4876	123	66	)	)	PUNCT
dpc-4876	123	67	12.76	12.76	NUM
dpc-4876	123	68	±	±	NUM
dpc-4876	123	69	0.8	0.8	NUM
dpc-4876	123	70	12.41	12.41	NUM
dpc-4876	123	71	±	±	NUM
dpc-4876	123	72	0.8	0.8	NUM
dpc-4876	123	73	0.119	0.119	NUM
dpc-4876	123	74	*	*	PUNCT
dpc-4876	123	75	*	*	PUNCT
dpc-4876	123	76	student	student	NOUN
dpc-4876	123	77	t	t	PROPN
dpc-4876	123	78	-	-	PUNCT
dpc-4876	123	79	test	test	NOUN
dpc-4876	123	80	was	be	AUX
dpc-4876	123	81	used	use	VERB
dpc-4876	123	82	to	to	PART
dpc-4876	123	83	compare	compare	VERB
dpc-4876	123	84	the	the	DET
dpc-4876	123	85	mean	mean	ADJ
dpc-4876	123	86	difference	difference	NOUN
dpc-4876	123	87	between	between	ADP
dpc-4876	123	88	groups	group	NOUN
dpc-4876	123	89	.	.	PUNCT
dpc-4876	124	1	*	*	PUNCT
dpc-4876	124	2	*	*	PUNCT
dpc-4876	124	3	chi	chi	ADJ
dpc-4876	124	4	-	-	PUNCT
dpc-4876	124	5	squared	square	VERB
dpc-4876	124	6	test	test	NOUN
dpc-4876	124	7	was	be	AUX
dpc-4876	124	8	used	use	VERB
dpc-4876	124	9	to	to	PART
dpc-4876	124	10	compare	compare	VERB
dpc-4876	124	11	proportions	proportion	NOUN
dpc-4876	124	12	between	between	ADP
dpc-4876	124	13	groups	group	NOUN
dpc-4876	124	14	.	.	PUNCT
dpc-4876	125	1	table	table	NOUN
dpc-4876	125	2	2	2	NUM
dpc-4876	125	3	.	.	PUNCT
dpc-4876	126	1	clinical	clinical	ADJ
dpc-4876	126	2	characteristics	characteristic	NOUN
dpc-4876	126	3	of	of	ADP
dpc-4876	126	4	pgh	pgh	PROPN
dpc-4876	126	5	patients	patient	NOUN
dpc-4876	126	6	(	(	PUNCT
dpc-4876	126	7	n=39	n=39	NOUN
dpc-4876	126	8	)	)	PUNCT
dpc-4876	126	9	.	.	PUNCT
dpc-4876	127	1	parameter	parameter	PROPN
dpc-4876	127	2	pgh	pgh	PROPN
dpc-4876	127	3	cases	case	NOUN
dpc-4876	127	4	(	(	PUNCT
dpc-4876	127	5	n=39	n=39	NOUN
dpc-4876	127	6	)	)	PUNCT
dpc-4876	127	7	age	age	NOUN
dpc-4876	127	8	at	at	ADP
dpc-4876	127	9	onset	onset	NOUN
dpc-4876	127	10	/	/	SYM
dpc-4876	127	11	years	year	NOUN
dpc-4876	127	12	(	(	PUNCT
dpc-4876	127	13	mean	mean	PROPN
dpc-4876	127	14	±	±	NUM
dpc-4876	127	15	sd	sd	NOUN
dpc-4876	127	16	)	)	PUNCT
dpc-4876	127	17	19.77	19.77	NUM
dpc-4876	127	18	±	±	NUM
dpc-4876	127	19	3.5	3.5	NUM
dpc-4876	127	20	categories	category	NOUN
dpc-4876	127	21	of	of	ADP
dpc-4876	127	22	age	age	NOUN
dpc-4876	127	23	at	at	ADP
dpc-4876	127	24	onset	onset	NOUN
dpc-4876	127	25	•	•	NOUN
dpc-4876	127	26	5	5	NUM
dpc-4876	127	27	10	10	NUM
dpc-4876	127	28	years	year	NOUN
dpc-4876	127	29	•	•	ADP
dpc-4876	127	30	10	10	NUM
dpc-4876	127	31	15	15	NUM
dpc-4876	127	32	years	year	NOUN
dpc-4876	127	33	•	•	NOUN
dpc-4876	127	34	15	15	NUM
dpc-4876	127	35	20	20	NUM
dpc-4876	127	36	years	year	NOUN
dpc-4876	127	37	•	•	ADV
dpc-4876	127	38	20	20	NUM
dpc-4876	127	39	25	25	NUM
dpc-4876	127	40	years	year	NOUN
dpc-4876	127	41	1	1	NUM
dpc-4876	127	42	(	(	PUNCT
dpc-4876	127	43	2.6	2.6	NUM
dpc-4876	127	44	%	%	NOUN
dpc-4876	127	45	)	)	PUNCT
dpc-4876	127	46	2	2	NUM
dpc-4876	127	47	(	(	PUNCT
dpc-4876	127	48	5.1	5.1	NUM
dpc-4876	127	49	%	%	NOUN
dpc-4876	127	50	)	)	PUNCT
dpc-4876	127	51	19	19	NUM
dpc-4876	127	52	(	(	PUNCT
dpc-4876	127	53	48.7	48.7	NUM
dpc-4876	127	54	%	%	NOUN
dpc-4876	127	55	)	)	PUNCT
dpc-4876	127	56	17	17	NUM
dpc-4876	127	57	(	(	PUNCT
dpc-4876	127	58	43.6	43.6	NUM
dpc-4876	127	59	%	%	NOUN
dpc-4876	127	60	)	)	PUNCT
dpc-4876	127	61	categories	category	NOUN
dpc-4876	127	62	of	of	ADP
dpc-4876	127	63	age	age	NOUN
dpc-4876	127	64	at	at	ADP
dpc-4876	127	65	onset	onset	NOUN
dpc-4876	127	66	•	•	NOUN
dpc-4876	127	67	≤	≤	NUM
dpc-4876	127	68	20	20	NUM
dpc-4876	127	69	years	year	NOUN
dpc-4876	127	70	•	•	ADP
dpc-4876	127	71	>	>	SYM
dpc-4876	127	72	20	20	NUM
dpc-4876	127	73	years	year	NOUN
dpc-4876	127	74	22	22	NUM
dpc-4876	127	75	(	(	PUNCT
dpc-4876	127	76	56.4	56.4	NUM
dpc-4876	127	77	%	%	NOUN
dpc-4876	127	78	)	)	PUNCT
dpc-4876	127	79	17	17	NUM
dpc-4876	127	80	(	(	PUNCT
dpc-4876	127	81	43.6	43.6	NUM
dpc-4876	127	82	%	%	NOUN
dpc-4876	127	83	)	)	PUNCT
dpc-4876	127	84	disease	disease	NOUN
dpc-4876	127	85	duration	duration	NOUN
dpc-4876	127	86	(	(	PUNCT
dpc-4876	127	87	years	year	NOUN
dpc-4876	127	88	)	)	PUNCT
dpc-4876	127	89	(	(	PUNCT
dpc-4876	127	90	mean	mean	VERB
dpc-4876	127	91	±	±	NUM
dpc-4876	127	92	sd	sd	NOUN
dpc-4876	127	93	)	)	PUNCT
dpc-4876	127	94	7.28	7.28	NUM
dpc-4876	127	95	±	±	NUM
dpc-4876	127	96	2.8	2.8	NUM
dpc-4876	127	97	categories	category	NOUN
dpc-4876	127	98	of	of	ADP
dpc-4876	127	99	disease	disease	NOUN
dpc-4876	127	100	duration	duration	NOUN
dpc-4876	127	101	•	•	NOUN
dpc-4876	127	102	1	1	NUM
dpc-4876	127	103	5	5	NUM
dpc-4876	127	104	years	year	NOUN
dpc-4876	127	105	•	•	ADP
dpc-4876	127	106	5	5	NUM
dpc-4876	127	107	10	10	NUM
dpc-4876	127	108	years	year	NOUN
dpc-4876	127	109	•	•	ADP
dpc-4876	127	110	10	10	NUM
dpc-4876	127	111	15	15	NUM
dpc-4876	127	112	years	year	NOUN
dpc-4876	127	113	6	6	NUM
dpc-4876	127	114	(	(	PUNCT
dpc-4876	127	115	15.4	15.4	NUM
dpc-4876	127	116	%	%	NOUN
dpc-4876	127	117	)	)	PUNCT
dpc-4876	127	118	25	25	NUM
dpc-4876	127	119	(	(	PUNCT
dpc-4876	127	120	64.1	64.1	NUM
dpc-4876	127	121	%	%	NOUN
dpc-4876	127	122	)	)	PUNCT
dpc-4876	127	123	8	8	NUM
dpc-4876	127	124	(	(	PUNCT
dpc-4876	127	125	20.5	20.5	NUM
dpc-4876	127	126	%	%	NOUN
dpc-4876	127	127	)	)	PUNCT
dpc-4876	127	128	categories	category	NOUN
dpc-4876	127	129	of	of	ADP
dpc-4876	127	130	disease	disease	NOUN
dpc-4876	127	131	duration	duration	NOUN
dpc-4876	127	132	•	•	NOUN
dpc-4876	127	133	≤	≤	NUM
dpc-4876	127	134	7	7	NUM
dpc-4876	127	135	years	year	NOUN
dpc-4876	127	136	20	20	NUM
dpc-4876	127	137	(	(	PUNCT
dpc-4876	127	138	51.3	51.3	NUM
dpc-4876	127	139	%	%	NOUN
dpc-4876	127	140	)	)	PUNCT
dpc-4876	127	141	cosmetic	cosmetic	ADJ
dpc-4876	127	142	procedure	procedure	NOUN
dpc-4876	128	1	•	•	NOUN
dpc-4876	129	1	yes	yes	INTJ
dpc-4876	129	2	12	12	NUM
dpc-4876	129	3	(	(	PUNCT
dpc-4876	129	4	30.8	30.8	NUM
dpc-4876	129	5	%	%	NOUN
dpc-4876	129	6	)	)	PUNCT
dpc-4876	129	7	family	family	NOUN
dpc-4876	129	8	history	history	NOUN
dpc-4876	129	9	•	•	NOUN
dpc-4876	130	1	yes	yes	INTJ
dpc-4876	130	2	35	35	NUM
dpc-4876	130	3	(	(	PUNCT
dpc-4876	130	4	89.7	89.7	NUM
dpc-4876	130	5	%	%	NOUN
dpc-4876	130	6	)	)	PUNCT
dpc-4876	130	7	disease	disease	NOUN
dpc-4876	130	8	severity	severity	NOUN
dpc-4876	130	9	•	•	NOUN
dpc-4876	130	10	mild	mild	ADJ
dpc-4876	130	11	1	1	NUM
dpc-4876	130	12	•	•	NOUN
dpc-4876	130	13	moderate	moderate	ADJ
dpc-4876	130	14	•	•	NUM
dpc-4876	130	15	severe	severe	ADJ
dpc-4876	130	16	29	29	NUM
dpc-4876	130	17	(	(	PUNCT
dpc-4876	130	18	2.6	2.6	NUM
dpc-4876	130	19	%	%	NOUN
dpc-4876	130	20	)	)	PUNCT
dpc-4876	130	21	9	9	NUM
dpc-4876	130	22	(	(	PUNCT
dpc-4876	130	23	23.1	23.1	NUM
dpc-4876	130	24	%	%	NOUN
dpc-4876	130	25	)	)	PUNCT
dpc-4876	130	26	(	(	PUNCT
dpc-4876	130	27	74.3	74.3	NUM
dpc-4876	130	28	%	%	NOUN
dpc-4876	130	29	)	)	PUNCT
dpc-4876	130	30	number	number	NOUN
dpc-4876	130	31	of	of	ADP
dpc-4876	130	32	affected	affect	VERB
dpc-4876	130	33	areas	area	NOUN
dpc-4876	130	34	•	•	NOUN
dpc-4876	130	35	two	two	NUM
dpc-4876	130	36	•	•	NUM
dpc-4876	130	37	three	three	NUM
dpc-4876	130	38	•	•	NOUN
dpc-4876	130	39	≥four	≥four	PRON
dpc-4876	130	40	3	3	NUM
dpc-4876	130	41	(	(	PUNCT
dpc-4876	130	42	7.7	7.7	NUM
dpc-4876	130	43	%	%	NOUN
dpc-4876	130	44	)	)	PUNCT
dpc-4876	130	45	3	3	NUM
dpc-4876	130	46	(	(	PUNCT
dpc-4876	130	47	7.7	7.7	NUM
dpc-4876	130	48	%	%	NOUN
dpc-4876	130	49	)	)	PUNCT
dpc-4876	130	50	33	33	NUM
dpc-4876	130	51	(	(	PUNCT
dpc-4876	130	52	84.6	84.6	NUM
dpc-4876	130	53	%	%	NOUN
dpc-4876	130	54	)	)	PUNCT
dpc-4876	130	55	statistically	statistically	ADV
dpc-4876	130	56	significant	significant	ADJ
dpc-4876	130	57	difference	difference	NOUN
dpc-4876	130	58	between	between	ADP
dpc-4876	130	59	the	the	DET
dpc-4876	130	60	two	two	NUM
dpc-4876	130	61	groups	group	NOUN
dpc-4876	130	62	as	as	ADP
dpc-4876	130	63	regards	regard	NOUN
dpc-4876	130	64	lc3	lc3	VERB
dpc-4876	130	65	concentration	concentration	NOUN
dpc-4876	130	66	by	by	ADP
dpc-4876	130	67	elisa	elisa	PROPN
dpc-4876	130	68	(	(	PUNCT
dpc-4876	130	69	p=0.229	p=0.229	NUM
dpc-4876	130	70	)	)	PUNCT
dpc-4876	130	71	,	,	PUNCT
dpc-4876	130	72	as	as	SCONJ
dpc-4876	130	73	shown	show	VERB
dpc-4876	130	74	in	in	ADP
dpc-4876	130	75	table	table	NOUN
dpc-4876	130	76	3	3	NUM
dpc-4876	130	77	.	.	PUNCT
dpc-4876	131	1	classification	classification	NOUN
dpc-4876	131	2	of	of	ADP
dpc-4876	131	3	pgh	pgh	PROPN
dpc-4876	131	4	patients	patient	NOUN
dpc-4876	131	5	according	accord	VERB
dpc-4876	131	6	to	to	ADP
dpc-4876	131	7	age	age	NOUN
dpc-4876	131	8	at	at	ADP
dpc-4876	131	9	onset	onset	NOUN
dpc-4876	131	10	(	(	PUNCT
dpc-4876	131	11	≤20	≤20	PROPN
dpc-4876	131	12	vs	vs	ADP
dpc-4876	131	13	>	>	NUM
dpc-4876	131	14	20	20	NUM
dpc-4876	131	15	years	year	NOUN
dpc-4876	131	16	old	old	ADJ
dpc-4876	131	17	)	)	PUNCT
dpc-4876	131	18	revealed	reveal	VERB
dpc-4876	131	19	a	a	DET
dpc-4876	131	20	statistically	statistically	ADV
dpc-4876	131	21	significant	significant	ADJ
dpc-4876	131	22	difference	difference	NOUN
dpc-4876	131	23	in	in	ADP
dpc-4876	131	24	lc3	lc3	NOUN
dpc-4876	131	25	concentration	concentration	NOUN
dpc-4876	131	26	by	by	ADP
dpc-4876	131	27	elisa	elisa	PROPN
dpc-4876	131	28	(	(	PUNCT
dpc-4876	131	29	p=0.042	p=0.042	NOUN
dpc-4876	131	30	)	)	PUNCT
dpc-4876	131	31	,	,	PUNCT
dpc-4876	131	32	as	as	SCONJ
dpc-4876	131	33	shown	show	VERB
dpc-4876	131	34	in	in	ADP
dpc-4876	131	35	table	table	NOUN
dpc-4876	131	36	3	3	NUM
dpc-4876	131	37	.	.	PUNCT
dpc-4876	132	1	in	in	ADP
dpc-4876	132	2	addition	addition	NOUN
dpc-4876	132	3	,	,	PUNCT
dpc-4876	132	4	the	the	DET
dpc-4876	132	5	classification	classification	NOUN
dpc-4876	132	6	of	of	ADP
dpc-4876	132	7	pgh	pgh	PROPN
dpc-4876	132	8	original	original	ADJ
dpc-4876	132	9	article	article	NOUN
dpc-4876	132	10	|	|	ADV
dpc-4876	132	11	dermatol	dermatol	ADJ
dpc-4876	132	12	pract	pract	NOUN
dpc-4876	132	13	concept	concept	NOUN
dpc-4876	132	14	.	.	PUNCT
dpc-4876	133	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	133	2	5	5	NUM
dpc-4876	133	3	table	table	NOUN
dpc-4876	133	4	3	3	NUM
dpc-4876	133	5	.	.	PUNCT
dpc-4876	133	6	comparison	comparison	NOUN
dpc-4876	133	7	of	of	ADP
dpc-4876	133	8	lc3	lc3	NOUN
dpc-4876	133	9	concentration	concentration	NOUN
dpc-4876	133	10	by	by	ADP
dpc-4876	133	11	elisa	elisa	NOUN
dpc-4876	133	12	and	and	CCONJ
dpc-4876	133	13	lc3	lc3	NOUN
dpc-4876	133	14	expression	expression	NOUN
dpc-4876	133	15	by	by	ADP
dpc-4876	133	16	pcr	pcr	NOUN
dpc-4876	133	17	between	between	ADP
dpc-4876	133	18	controls	control	NOUN
dpc-4876	133	19	and	and	CCONJ
dpc-4876	133	20	pgh	pgh	PROPN
dpc-4876	133	21	patients	patient	NOUN
dpc-4876	133	22	according	accord	VERB
dpc-4876	133	23	to	to	ADP
dpc-4876	133	24	the	the	DET
dpc-4876	133	25	age	age	NOUN
dpc-4876	133	26	at	at	ADP
dpc-4876	133	27	onset	onset	NOUN
dpc-4876	133	28	,	,	PUNCT
dpc-4876	133	29	disease	disease	NOUN
dpc-4876	133	30	duration	duration	NOUN
dpc-4876	133	31	,	,	PUNCT
dpc-4876	133	32	and	and	CCONJ
dpc-4876	133	33	disease	disease	NOUN
dpc-4876	133	34	severity	severity	NOUN
dpc-4876	133	35	.	.	PUNCT
dpc-4876	134	1	lc3	lc3	NOUN
dpc-4876	134	2	concentration	concentration	NOUN
dpc-4876	134	3	by	by	ADP
dpc-4876	134	4	elisa	elisa	NOUN
dpc-4876	134	5	lc3	lc3	NOUN
dpc-4876	134	6	expression	expression	NOUN
dpc-4876	134	7	by	by	ADP
dpc-4876	134	8	pcr	pcr	ADJ
dpc-4876	134	9	comparison	comparison	NOUN
dpc-4876	134	10	between	between	ADP
dpc-4876	134	11	controls	control	NOUN
dpc-4876	134	12	and	and	CCONJ
dpc-4876	134	13	pgh	pgh	PROPN
dpc-4876	134	14	patients	patient	NOUN
dpc-4876	134	15	:	:	PUNCT
dpc-4876	134	16	group	group	NOUN
dpc-4876	134	17	1	1	NUM
dpc-4876	134	18	:	:	PUNCT
dpc-4876	134	19	controls	control	NOUN
dpc-4876	134	20	(	(	PUNCT
dpc-4876	134	21	n=21	n=21	NOUN
dpc-4876	134	22	)	)	PUNCT
dpc-4876	134	23	28.50	28.50	NUM
dpc-4876	134	24	±	±	NUM
dpc-4876	134	25	12.8	12.8	NUM
dpc-4876	134	26	27	27	NUM
dpc-4876	134	27	(	(	PUNCT
dpc-4876	134	28	15.5	15.5	NUM
dpc-4876	134	29	–	–	SYM
dpc-4876	134	30	79	79	NUM
dpc-4876	134	31	)	)	PUNCT
dpc-4876	134	32	0.71	0.71	NUM
dpc-4876	134	33	±	±	NUM
dpc-4876	134	34	0.3	0.3	NUM
dpc-4876	134	35	0.7	0.7	NUM
dpc-4876	134	36	(	(	PUNCT
dpc-4876	134	37	0.4	0.4	NUM
dpc-4876	134	38	–	–	SYM
dpc-4876	134	39	1.3	1.3	NUM
dpc-4876	134	40	)	)	PUNCT
dpc-4876	134	41	group	group	NOUN
dpc-4876	134	42	2	2	NUM
dpc-4876	134	43	:	:	PUNCT
dpc-4876	134	44	pgh	pgh	NOUN
dpc-4876	134	45	cases	case	NOUN
dpc-4876	134	46	(	(	PUNCT
dpc-4876	134	47	n=39	n=39	NOUN
dpc-4876	134	48	)	)	PUNCT
dpc-4876	134	49	44.16	44.16	NUM
dpc-4876	134	50	±	±	NUM
dpc-4876	134	51	43.3	43.3	NUM
dpc-4876	134	52	29	29	NUM
dpc-4876	134	53	(	(	PUNCT
dpc-4876	134	54	3	3	NUM
dpc-4876	134	55	–	–	SYM
dpc-4876	134	56	172	172	NUM
dpc-4876	134	57	)	)	PUNCT
dpc-4876	134	58	5.10	5.10	NUM
dpc-4876	134	59	±	±	NUM
dpc-4876	134	60	1.4	1.4	NUM
dpc-4876	134	61	5	5	NUM
dpc-4876	134	62	(	(	PUNCT
dpc-4876	134	63	2	2	NUM
dpc-4876	134	64	–	–	SYM
dpc-4876	134	65	11	11	NUM
dpc-4876	134	66	)	)	PUNCT
dpc-4876	134	67	p	p	NOUN
dpc-4876	134	68	-	-	PUNCT
dpc-4876	134	69	value	value	NOUN
dpc-4876	134	70	=	=	PUNCT
dpc-4876	134	71	0.229	0.229	NUM
dpc-4876	134	72	*	*	PUNCT
dpc-4876	134	73	<	<	X
dpc-4876	134	74	0.001	0.001	NUM
dpc-4876	134	75	*	*	PUNCT
dpc-4876	134	76	*	*	PUNCT
dpc-4876	134	77	according	accord	VERB
dpc-4876	134	78	to	to	ADP
dpc-4876	134	79	age	age	NOUN
dpc-4876	134	80	at	at	ADP
dpc-4876	134	81	onset	onset	NOUN
dpc-4876	134	82	(	(	PUNCT
dpc-4876	134	83	≤	≤	ADV
dpc-4876	134	84	20	20	NUM
dpc-4876	134	85	vs	vs	ADP
dpc-4876	134	86	>	>	X
dpc-4876	134	87	20	20	NUM
dpc-4876	134	88	):	):	PUNCT
dpc-4876	134	89	≤	≤	NUM
dpc-4876	134	90	20	20	NUM
dpc-4876	134	91	years	year	NOUN
dpc-4876	134	92	(	(	PUNCT
dpc-4876	134	93	n=22	n=22	PROPN
dpc-4876	134	94	)	)	PUNCT
dpc-4876	134	95	36.87	36.87	NUM
dpc-4876	134	96	±	±	NUM
dpc-4876	134	97	31.5	31.5	NUM
dpc-4876	134	98	26	26	NUM
dpc-4876	134	99	(	(	PUNCT
dpc-4876	134	100	3	3	NUM
dpc-4876	134	101	–	–	SYM
dpc-4876	134	102	172	172	NUM
dpc-4876	134	103	)	)	PUNCT
dpc-4876	134	104	4.89	4.89	NUM
dpc-4876	134	105	±	±	NUM
dpc-4876	134	106	2.1	2.1	NUM
dpc-4876	134	107	4.6	4.6	NUM
dpc-4876	134	108	(	(	PUNCT
dpc-4876	134	109	2.1	2.1	NUM
dpc-4876	134	110	–	–	PUNCT
dpc-4876	134	111	11	11	NUM
dpc-4876	134	112	)	)	PUNCT
dpc-4876	134	113	>	>	SYM
dpc-4876	134	114	20	20	NUM
dpc-4876	134	115	years	year	NOUN
dpc-4876	134	116	(	(	PUNCT
dpc-4876	134	117	n=17	n=17	NOUN
dpc-4876	134	118	)	)	PUNCT
dpc-4876	134	119	4.89	4.89	NUM
dpc-4876	134	120	±	±	NUM
dpc-4876	134	121	2.1	2.1	NUM
dpc-4876	134	122	4.6	4.6	NUM
dpc-4876	134	123	(	(	PUNCT
dpc-4876	134	124	2.1	2.1	NUM
dpc-4876	134	125	–	–	PUNCT
dpc-4876	134	126	11	11	NUM
dpc-4876	134	127	)	)	PUNCT
dpc-4876	134	128	5.38	5.38	NUM
dpc-4876	134	129	±	±	NUM
dpc-4876	134	130	1.6	1.6	NUM
dpc-4876	134	131	5.2	5.2	NUM
dpc-4876	134	132	(	(	PUNCT
dpc-4876	134	133	2.5	2.5	NUM
dpc-4876	134	134	–	–	SYM
dpc-4876	134	135	8)	8)	NUM
dpc-4876	134	136	p	p	NOUN
dpc-4876	134	137	-	-	PUNCT
dpc-4876	134	138	value	value	NOUN
dpc-4876	134	139	0.042	0.042	NUM
dpc-4876	134	140	*	*	NOUN
dpc-4876	134	141	0.081	0.081	NUM
dpc-4876	134	142	*	*	PUNCT
dpc-4876	134	143	according	accord	VERB
dpc-4876	134	144	to	to	ADP
dpc-4876	134	145	disease	disease	NOUN
dpc-4876	134	146	duration	duration	NOUN
dpc-4876	134	147	(	(	PUNCT
dpc-4876	134	148	≤	≤	NOUN
dpc-4876	134	149	7	7	NUM
dpc-4876	134	150	vs	vs	ADP
dpc-4876	134	151	>	>	X
dpc-4876	134	152	7	7	NUM
dpc-4876	134	153	):	):	PUNCT
dpc-4876	134	154	≤	≤	NUM
dpc-4876	134	155	7	7	NUM
dpc-4876	134	156	years	year	NOUN
dpc-4876	134	157	(	(	PUNCT
dpc-4876	134	158	n=20	n=20	PROPN
dpc-4876	134	159	)	)	PUNCT
dpc-4876	134	160	48.59	48.59	NUM
dpc-4876	134	161	±	±	NUM
dpc-4876	134	162	41.4	41.4	NUM
dpc-4876	134	163	32	32	NUM
dpc-4876	134	164	(	(	PUNCT
dpc-4876	134	165	20.5	20.5	NUM
dpc-4876	134	166	–	–	PUNCT
dpc-4876	134	167	171	171	NUM
dpc-4876	134	168	)	)	PUNCT
dpc-4876	134	169	5.52	5.52	NUM
dpc-4876	134	170	±	±	NUM
dpc-4876	134	171	1.2	1.2	NUM
dpc-4876	134	172	5.2	5.2	NUM
dpc-4876	134	173	(	(	PUNCT
dpc-4876	134	174	3.5	3.5	NUM
dpc-4876	134	175	–	–	SYM
dpc-4876	134	176	8)	8)	NUM
dpc-4876	134	177	>	>	SYM
dpc-4876	134	178	7	7	NUM
dpc-4876	134	179	years	year	NOUN
dpc-4876	134	180	(	(	PUNCT
dpc-4876	134	181	n=19	n=19	PROPN
dpc-4876	134	182	)	)	PUNCT
dpc-4876	134	183	39.51	39.51	NUM
dpc-4876	134	184	±	±	NUM
dpc-4876	134	185	35.9	35.9	NUM
dpc-4876	134	186	25	25	NUM
dpc-4876	134	187	(	(	PUNCT
dpc-4876	134	188	3	3	NUM
dpc-4876	134	189	–	–	PUNCT
dpc-4876	134	190	172.5	172.5	NUM
dpc-4876	134	191	)	)	PUNCT
dpc-4876	134	192	4.66	4.66	NUM
dpc-4876	134	193	±	±	NUM
dpc-4876	134	194	2.3	2.3	NUM
dpc-4876	134	195	4.5	4.5	NUM
dpc-4876	134	196	(	(	PUNCT
dpc-4876	134	197	2.1	2.1	NUM
dpc-4876	134	198	–	–	PUNCT
dpc-4876	134	199	11	11	NUM
dpc-4876	134	200	)	)	PUNCT
dpc-4876	134	201	p	p	NOUN
dpc-4876	134	202	-	-	PUNCT
dpc-4876	134	203	value	value	NOUN
dpc-4876	134	204	0.024	0.024	NUM
dpc-4876	134	205	*	*	NOUN
dpc-4876	134	206	0.016	0.016	NUM
dpc-4876	134	207	*	*	PUNCT
dpc-4876	134	208	according	accord	VERB
dpc-4876	134	209	to	to	ADP
dpc-4876	134	210	disease	disease	NOUN
dpc-4876	134	211	severity	severity	NOUN
dpc-4876	134	212	:	:	PUNCT
dpc-4876	134	213	mild	mild	ADJ
dpc-4876	134	214	/	/	SYM
dpc-4876	134	215	moderate	moderate	ADJ
dpc-4876	134	216	(	(	PUNCT
dpc-4876	134	217	n=10	n=10	NOUN
dpc-4876	134	218	)	)	PUNCT
dpc-4876	134	219	37.06	37.06	NUM
dpc-4876	134	220	±	±	NUM
dpc-4876	134	221	28.3	28.3	NUM
dpc-4876	134	222	28.9	28.9	NUM
dpc-4876	134	223	(	(	PUNCT
dpc-4876	134	224	11.5	11.5	NUM
dpc-4876	134	225	–	–	SYM
dpc-4876	134	226	143	143	NUM
dpc-4876	134	227	)	)	PUNCT
dpc-4876	134	228	4.51	4.51	NUM
dpc-4876	134	229	±	±	NUM
dpc-4876	134	230	1.4	1.4	NUM
dpc-4876	134	231	4.9	4.9	NUM
dpc-4876	134	232	(	(	PUNCT
dpc-4876	134	233	2.1	2.1	NUM
dpc-4876	134	234	–	–	SYM
dpc-4876	134	235	6.2	6.2	NUM
dpc-4876	134	236	)	)	PUNCT
dpc-4876	134	237	severe	severe	ADJ
dpc-4876	134	238	(	(	PUNCT
dpc-4876	134	239	n=29	n=29	ADJ
dpc-4876	134	240	)	)	PUNCT
dpc-4876	134	241	46.61	46.61	NUM
dpc-4876	134	242	±	±	NUM
dpc-4876	134	243	45.3	45.3	NUM
dpc-4876	134	244	29.3	29.3	NUM
dpc-4876	134	245	(	(	PUNCT
dpc-4876	134	246	3	3	NUM
dpc-4876	134	247	–	–	PUNCT
dpc-4876	134	248	172.5	172.5	NUM
dpc-4876	134	249	)	)	PUNCT
dpc-4876	134	250	5.31	5.31	NUM
dpc-4876	134	251	±	±	NUM
dpc-4876	134	252	2.1	2.1	NUM
dpc-4876	134	253	5	5	NUM
dpc-4876	134	254	(	(	PUNCT
dpc-4876	134	255	2.1	2.1	NUM
dpc-4876	134	256	–	–	PUNCT
dpc-4876	134	257	11	11	NUM
dpc-4876	134	258	)	)	PUNCT
dpc-4876	134	259	p	p	NOUN
dpc-4876	134	260	-	-	PUNCT
dpc-4876	134	261	value	value	NOUN
dpc-4876	134	262	0.579	0.579	NUM
dpc-4876	134	263	*	*	NOUN
dpc-4876	134	264	0.418	0.418	NUM
dpc-4876	134	265	*	*	PUNCT
dpc-4876	134	266	*	*	PUNCT
dpc-4876	134	267	mann	mann	PROPN
dpc-4876	134	268	-	-	PUNCT
dpc-4876	134	269	whitney	whitney	PROPN
dpc-4876	134	270	u	u	PROPN
dpc-4876	134	271	test	test	NOUN
dpc-4876	134	272	was	be	AUX
dpc-4876	134	273	used	use	VERB
dpc-4876	134	274	to	to	PART
dpc-4876	134	275	compare	compare	VERB
dpc-4876	134	276	the	the	DET
dpc-4876	134	277	median	median	ADJ
dpc-4876	134	278	difference	difference	NOUN
dpc-4876	134	279	between	between	ADP
dpc-4876	134	280	groups	group	NOUN
dpc-4876	134	281	;	;	PUNCT
dpc-4876	134	282	*	*	PUNCT
dpc-4876	134	283	*	*	PUNCT
dpc-4876	134	284	student	student	NOUN
dpc-4876	134	285	t	t	PROPN
dpc-4876	134	286	-	-	PUNCT
dpc-4876	134	287	test	test	NOUN
dpc-4876	134	288	was	be	AUX
dpc-4876	134	289	used	use	VERB
dpc-4876	134	290	to	to	PART
dpc-4876	134	291	compare	compare	VERB
dpc-4876	134	292	the	the	DET
dpc-4876	134	293	mean	mean	ADJ
dpc-4876	134	294	difference	difference	NOUN
dpc-4876	134	295	between	between	ADP
dpc-4876	134	296	groups	group	NOUN
dpc-4876	134	297	figure	figure	VERB
dpc-4876	134	298	1	1	NUM
dpc-4876	134	299	.	.	PUNCT
dpc-4876	134	300	correlation	correlation	NOUN
dpc-4876	134	301	between	between	ADP
dpc-4876	134	302	lc3	lc3	NOUN
dpc-4876	134	303	concentration	concentration	NOUN
dpc-4876	134	304	and	and	CCONJ
dpc-4876	134	305	lc3	lc3	NOUN
dpc-4876	134	306	gene	gene	NOUN
dpc-4876	134	307	expression	expression	NOUN
dpc-4876	134	308	in	in	ADP
dpc-4876	134	309	controls	control	NOUN
dpc-4876	134	310	(	(	PUNCT
dpc-4876	134	311	n=21	n=21	NOUN
dpc-4876	134	312	)	)	PUNCT
dpc-4876	134	313	.	.	PUNCT
dpc-4876	135	1	pgh	pgh	PROPN
dpc-4876	135	2	cases	case	NOUN
dpc-4876	135	3	compared	compare	VERB
dpc-4876	135	4	to	to	ADP
dpc-4876	135	5	the	the	DET
dpc-4876	135	6	controls	control	NOUN
dpc-4876	135	7	,	,	PUNCT
dpc-4876	135	8	but	but	CCONJ
dpc-4876	135	9	this	this	DET
dpc-4876	135	10	increase	increase	NOUN
dpc-4876	135	11	was	be	AUX
dpc-4876	135	12	not	not	PART
dpc-4876	135	13	significant	significant	ADJ
dpc-4876	135	14	.	.	PUNCT
dpc-4876	136	1	more	more	ADV
dpc-4876	136	2	interestingly	interestingly	ADV
dpc-4876	136	3	,	,	PUNCT
dpc-4876	136	4	the	the	DET
dpc-4876	136	5	expression	expression	NOUN
dpc-4876	136	6	levels	level	NOUN
dpc-4876	136	7	of	of	ADP
dpc-4876	136	8	the	the	DET
dpc-4876	136	9	lc3	lc3	NOUN
dpc-4876	136	10	gene	gene	NOUN
dpc-4876	136	11	were	be	AUX
dpc-4876	136	12	not	not	PART
dpc-4876	136	13	significantly	significantly	ADV
dpc-4876	136	14	higher	high	ADJ
dpc-4876	136	15	in	in	ADP
dpc-4876	136	16	pgh	pgh	PROPN
dpc-4876	136	17	cases	case	NOUN
dpc-4876	136	18	with	with	ADP
dpc-4876	136	19	an	an	DET
dpc-4876	136	20	age	age	NOUN
dpc-4876	136	21	at	at	ADP
dpc-4876	136	22	onset	onset	NOUN
dpc-4876	136	23	of	of	ADP
dpc-4876	136	24	>	>	SYM
dpc-4876	136	25	20	20	NUM
dpc-4876	136	26	years	year	NOUN
dpc-4876	136	27	old	old	ADJ
dpc-4876	136	28	and	and	CCONJ
dpc-4876	136	29	significantly	significantly	ADV
dpc-4876	136	30	higher	high	ADJ
dpc-4876	136	31	in	in	ADV
dpc-4876	136	32	and	and	CCONJ
dpc-4876	136	33	might	might	AUX
dpc-4876	136	34	contribute	contribute	VERB
dpc-4876	136	35	to	to	ADP
dpc-4876	136	36	ethnic	ethnic	ADJ
dpc-4876	136	37	skin	skin	NOUN
dpc-4876	136	38	color	color	NOUN
dpc-4876	136	39	diversity	diversity	NOUN
dpc-4876	136	40	by	by	ADP
dpc-4876	136	41	regulating	regulate	VERB
dpc-4876	136	42	melanosome	melanosome	NOUN
dpc-4876	136	43	degradation	degradation	NOUN
dpc-4876	136	44	in	in	ADP
dpc-4876	136	45	keratinocytes	keratinocyte	NOUN
dpc-4876	136	46	[	[	X
dpc-4876	136	47	15	15	NUM
dpc-4876	136	48	]	]	PUNCT
dpc-4876	136	49	.	.	PUNCT
dpc-4876	137	1	one	one	NUM
dpc-4876	137	2	of	of	ADP
dpc-4876	137	3	the	the	DET
dpc-4876	137	4	autophagic	autophagic	ADJ
dpc-4876	137	5	proteins	protein	NOUN
dpc-4876	137	6	is	be	AUX
dpc-4876	137	7	the	the	DET
dpc-4876	137	8	microtubule	microtubule	NOUN
dpc-4876	137	9	-	-	PUNCT
dpc-4876	137	10	associated	associate	VERB
dpc-4876	137	11	protein	protein	NOUN
dpc-4876	137	12	light	light	NOUN
dpc-4876	137	13	chain	chain	NOUN
dpc-4876	137	14	3	3	NUM
dpc-4876	137	15	(	(	PUNCT
dpc-4876	137	16	lc31a/1b	lc31a/1b	PROPN
dpc-4876	137	17	)	)	PUNCT
dpc-4876	137	18	,	,	PUNCT
dpc-4876	137	19	with	with	ADP
dpc-4876	137	20	its	its	PRON
dpc-4876	137	21	cytosolic	cytosolic	ADJ
dpc-4876	137	22	form	form	NOUN
dpc-4876	137	23	figure	figure	NOUN
dpc-4876	137	24	2	2	NUM
dpc-4876	137	25	.	.	PUNCT
dpc-4876	137	26	correlation	correlation	NOUN
dpc-4876	137	27	between	between	ADP
dpc-4876	137	28	lc3	lc3	NOUN
dpc-4876	137	29	concentration	concentration	NOUN
dpc-4876	137	30	and	and	CCONJ
dpc-4876	137	31	lc3	lc3	NOUN
dpc-4876	137	32	gene	gene	NOUN
dpc-4876	137	33	expression	expression	NOUN
dpc-4876	137	34	in	in	ADP
dpc-4876	137	35	pgh	pgh	PROPN
dpc-4876	137	36	patients	patient	NOUN
dpc-4876	137	37	(	(	PUNCT
dpc-4876	137	38	n=39	n=39	NOUN
dpc-4876	137	39	)	)	PUNCT
dpc-4876	137	40	.	.	PUNCT
dpc-4876	138	1	6	6	NUM
dpc-4876	138	2	original	original	ADJ
dpc-4876	138	3	article	article	NOUN
dpc-4876	138	4	|	|	ADV
dpc-4876	138	5	dermatol	dermatol	ADJ
dpc-4876	138	6	pract	pract	NOUN
dpc-4876	138	7	concept	concept	NOUN
dpc-4876	138	8	.	.	PUNCT
dpc-4876	139	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	139	2	figure	figure	NOUN
dpc-4876	139	3	3	3	NUM
dpc-4876	139	4	.	.	PUNCT
dpc-4876	139	5	correlation	correlation	NOUN
dpc-4876	139	6	between	between	ADP
dpc-4876	139	7	lc3	lc3	NOUN
dpc-4876	139	8	gene	gene	NOUN
dpc-4876	139	9	expression	expression	NOUN
dpc-4876	139	10	and	and	CCONJ
dpc-4876	139	11	age	age	NOUN
dpc-4876	139	12	at	at	ADP
dpc-4876	139	13	onset	onset	NOUN
dpc-4876	139	14	in	in	ADP
dpc-4876	139	15	patients	patient	NOUN
dpc-4876	139	16	(	(	PUNCT
dpc-4876	139	17	n=39	n=39	NOUN
dpc-4876	139	18	)	)	PUNCT
dpc-4876	139	19	.	.	PUNCT
dpc-4876	140	1	figure	figure	VERB
dpc-4876	140	2	4	4	NUM
dpc-4876	140	3	.	.	PUNCT
dpc-4876	140	4	correlation	correlation	NOUN
dpc-4876	140	5	between	between	ADP
dpc-4876	140	6	lc3	lc3	NOUN
dpc-4876	140	7	concentration	concentration	NOUN
dpc-4876	140	8	and	and	CCONJ
dpc-4876	140	9	age	age	NOUN
dpc-4876	140	10	at	at	ADP
dpc-4876	140	11	onset	onset	NOUN
dpc-4876	140	12	in	in	ADP
dpc-4876	140	13	patients	patient	NOUN
dpc-4876	140	14	(	(	PUNCT
dpc-4876	140	15	n=39	n=39	NOUN
dpc-4876	140	16	)	)	PUNCT
dpc-4876	140	17	.	.	PUNCT
dpc-4876	141	1	figure	figure	NOUN
dpc-4876	141	2	5	5	NUM
dpc-4876	141	3	.	.	PUNCT
dpc-4876	141	4	correlation	correlation	NOUN
dpc-4876	141	5	between	between	ADP
dpc-4876	141	6	lc3	lc3	NOUN
dpc-4876	141	7	gene	gene	NOUN
dpc-4876	141	8	expression	expression	NOUN
dpc-4876	141	9	and	and	CCONJ
dpc-4876	141	10	disease	disease	NOUN
dpc-4876	141	11	duration	duration	NOUN
dpc-4876	141	12	in	in	ADP
dpc-4876	141	13	patients	patient	NOUN
dpc-4876	141	14	(	(	PUNCT
dpc-4876	141	15	n=39	n=39	NOUN
dpc-4876	141	16	)	)	PUNCT
dpc-4876	141	17	.	.	PUNCT
dpc-4876	142	1	figure	figure	VERB
dpc-4876	142	2	6	6	NUM
dpc-4876	142	3	.	.	PUNCT
dpc-4876	142	4	correlation	correlation	NOUN
dpc-4876	142	5	between	between	ADP
dpc-4876	142	6	lc3	lc3	NOUN
dpc-4876	142	7	concentration	concentration	NOUN
dpc-4876	142	8	and	and	CCONJ
dpc-4876	142	9	disease	disease	NOUN
dpc-4876	142	10	duration	duration	NOUN
dpc-4876	142	11	in	in	ADP
dpc-4876	142	12	patients	patient	NOUN
dpc-4876	142	13	(	(	PUNCT
dpc-4876	142	14	n=39	n=39	NOUN
dpc-4876	142	15	)	)	PUNCT
dpc-4876	142	16	.	.	PUNCT
dpc-4876	143	1	table	table	NOUN
dpc-4876	143	2	4	4	NUM
dpc-4876	143	3	.	.	PUNCT
dpc-4876	143	4	multivariable	multivariable	ADJ
dpc-4876	143	5	logistic	logistic	ADJ
dpc-4876	143	6	regression	regression	NOUN
dpc-4876	143	7	analysis	analysis	NOUN
dpc-4876	143	8	for	for	ADP
dpc-4876	143	9	pgh	pgh	PROPN
dpc-4876	143	10	predictors	predictor	NOUN
dpc-4876	143	11	.	.	PUNCT
dpc-4876	144	1	variable	variable	ADJ
dpc-4876	144	2	aor	aor	PROPN
dpc-4876	144	3	95	95	NUM
dpc-4876	144	4	%	%	NOUN
dpc-4876	144	5	ci	ci	NOUN
dpc-4876	144	6	p	p	ADJ
dpc-4876	144	7	-	-	PUNCT
dpc-4876	144	8	value	value	NOUN
dpc-4876	144	9	age	age	NOUN
dpc-4876	144	10	/	/	SYM
dpc-4876	144	11	years	year	NOUN
dpc-4876	144	12	0.993	0.993	NUM
dpc-4876	144	13	0.837	0.837	NUM
dpc-4876	144	14	–	–	PUNCT
dpc-4876	144	15	1.178	1.178	NUM
dpc-4876	144	16	=	=	SYM
dpc-4876	144	17	0.934	0.934	NUM
dpc-4876	144	18	sex	sex	NOUN
dpc-4876	144	19	(	(	PUNCT
dpc-4876	144	20	female	female	NOUN
dpc-4876	144	21	)	)	PUNCT
dpc-4876	144	22	2.286	2.286	NUM
dpc-4876	144	23	0.674	0.674	NUM
dpc-4876	144	24	–	–	PUNCT
dpc-4876	144	25	7.754	7.754	NUM
dpc-4876	144	26	=	=	SYM
dpc-4876	144	27	0.185	0.185	NUM
dpc-4876	144	28	hgb	hgb	PROPN
dpc-4876	144	29	leve	leve	PROPN
dpc-4876	144	30	(	(	PUNCT
dpc-4876	144	31	g	g	PROPN
dpc-4876	144	32	/	/	SYM
dpc-4876	144	33	dl	dl	PROPN
dpc-4876	144	34	)	)	PUNCT
dpc-4876	144	35	0.571	0.571	NUM
dpc-4876	144	36	0.286	0.286	NUM
dpc-4876	144	37	–	–	PUNCT
dpc-4876	144	38	1.143	1.143	NUM
dpc-4876	144	39	=	=	SYM
dpc-4876	144	40	0.113	0.113	NUM
dpc-4876	144	41	lc3	lc3	NOUN
dpc-4876	144	42	conc	conc	VERB
dpc-4876	144	43	.	.	PUNCT
dpc-4876	145	1	by	by	ADP
dpc-4876	145	2	elisa	elisa	NOUN
dpc-4876	145	3	1.019	1.019	NUM
dpc-4876	145	4	0.993	0.993	NUM
dpc-4876	145	5	–	–	PUNCT
dpc-4876	145	6	1.047	1.047	NUM
dpc-4876	145	7	=	=	SYM
dpc-4876	145	8	0.159	0.159	NUM
dpc-4876	145	9	lc3	lc3	NOUN
dpc-4876	145	10	gene	gene	NOUN
dpc-4876	145	11	expression	expression	NOUN
dpc-4876	145	12	by	by	ADP
dpc-4876	145	13	pcr	pcr	PROPN
dpc-4876	145	14	6.031	6.031	NUM
dpc-4876	145	15	2.256	2.256	NUM
dpc-4876	145	16	–	–	PUNCT
dpc-4876	145	17	9.162	9.162	NUM
dpc-4876	145	18	<	<	SYM
dpc-4876	145	19	0.001	0.001	NUM
dpc-4876	145	20	abbreviations	abbreviation	NOUN
dpc-4876	145	21	:	:	PUNCT
dpc-4876	145	22	aor	aor	NOUN
dpc-4876	145	23	,	,	PUNCT
dpc-4876	145	24	adjusted	adjust	VERB
dpc-4876	145	25	odds	odd	NOUN
dpc-4876	145	26	ratio	ratio	NOUN
dpc-4876	145	27	,	,	PUNCT
dpc-4876	145	28	ci	ci	NOUN
dpc-4876	145	29	,	,	PUNCT
dpc-4876	145	30	confidence	confidence	NOUN
dpc-4876	145	31	interval	interval	NOUN
dpc-4876	145	32	(	(	PUNCT
dpc-4876	145	33	lc3	lc3	NOUN
dpc-4876	145	34	-	-	PUNCT
dpc-4876	145	35	i	i	NOUN
dpc-4876	145	36	)	)	PUNCT
dpc-4876	145	37	converted	convert	VERB
dpc-4876	145	38	to	to	ADP
dpc-4876	145	39	a	a	DET
dpc-4876	145	40	conjugated	conjugate	VERB
dpc-4876	145	41	form	form	NOUN
dpc-4876	145	42	(	(	PUNCT
dpc-4876	145	43	lc3	lc3	NOUN
dpc-4876	145	44	-	-	PUNCT
dpc-4876	145	45	ii	ii	NOUN
dpc-4876	145	46	)	)	PUNCT
dpc-4876	145	47	during	during	ADP
dpc-4876	145	48	the	the	DET
dpc-4876	145	49	activated	activate	VERB
dpc-4876	145	50	autophagic	autophagic	ADJ
dpc-4876	145	51	process	process	NOUN
dpc-4876	145	52	[	[	X
dpc-4876	145	53	14	14	NUM
dpc-4876	145	54	]	]	PUNCT
dpc-4876	145	55	.	.	PUNCT
dpc-4876	146	1	therefore	therefore	ADV
dpc-4876	146	2	,	,	PUNCT
dpc-4876	146	3	lc3	lc3	VERB
dpc-4876	146	4	detection	detection	NOUN
dpc-4876	146	5	by	by	ADP
dpc-4876	146	6	immunoblotting	immunoblotte	VERB
dpc-4876	146	7	or	or	CCONJ
dpc-4876	146	8	immunofluorescence	immunofluorescence	NOUN
dpc-4876	146	9	is	be	AUX
dpc-4876	146	10	considered	consider	VERB
dpc-4876	146	11	a	a	DET
dpc-4876	146	12	valuable	valuable	ADJ
dpc-4876	146	13	tool	tool	NOUN
dpc-4876	146	14	for	for	ADP
dpc-4876	146	15	monitoring	monitor	VERB
dpc-4876	146	16	autophagy	autophagy	NOUN
dpc-4876	146	17	[	[	X
dpc-4876	146	18	18	18	NUM
dpc-4876	146	19	]	]	PUNCT
dpc-4876	146	20	.	.	PUNCT
dpc-4876	147	1	it	it	PRON
dpc-4876	147	2	must	must	AUX
dpc-4876	147	3	be	be	AUX
dpc-4876	147	4	noted	note	VERB
dpc-4876	147	5	that	that	SCONJ
dpc-4876	147	6	the	the	DET
dpc-4876	147	7	role	role	NOUN
dpc-4876	147	8	of	of	ADP
dpc-4876	147	9	lc3	lc3	NOUN
dpc-4876	147	10	in	in	ADP
dpc-4876	147	11	regulating	regulate	VERB
dpc-4876	147	12	pigmentation	pigmentation	NOUN
dpc-4876	147	13	is	be	AUX
dpc-4876	147	14	complex	complex	ADJ
dpc-4876	147	15	and	and	CCONJ
dpc-4876	147	16	still	still	ADV
dpc-4876	147	17	controversial	controversial	ADJ
dpc-4876	147	18	.	.	PUNCT
dpc-4876	148	1	increased	increase	VERB
dpc-4876	148	2	lc3	lc3	NOUN
dpc-4876	148	3	has	have	AUX
dpc-4876	148	4	been	be	AUX
dpc-4876	148	5	linked	link	VERB
dpc-4876	148	6	to	to	ADP
dpc-4876	148	7	both	both	PRON
dpc-4876	148	8	increased	increase	VERB
dpc-4876	148	9	and	and	CCONJ
dpc-4876	148	10	decreased	decrease	VERB
dpc-4876	148	11	pigmentation	pigmentation	NOUN
dpc-4876	148	12	.	.	PUNCT
dpc-4876	149	1	the	the	DET
dpc-4876	149	2	current	current	ADJ
dpc-4876	149	3	study	study	NOUN
dpc-4876	149	4	evaluated	evaluate	VERB
dpc-4876	149	5	both	both	CCONJ
dpc-4876	149	6	the	the	DET
dpc-4876	149	7	expression	expression	NOUN
dpc-4876	149	8	levels	level	NOUN
dpc-4876	149	9	of	of	ADP
dpc-4876	149	10	the	the	DET
dpc-4876	149	11	lc3	lc3	NOUN
dpc-4876	149	12	gene	gene	NOUN
dpc-4876	149	13	by	by	ADP
dpc-4876	149	14	pcr	pcr	PROPN
dpc-4876	149	15	and	and	CCONJ
dpc-4876	149	16	serum	serum	NOUN
dpc-4876	149	17	lc3	lc3	NOUN
dpc-4876	149	18	concentration	concentration	NOUN
dpc-4876	149	19	by	by	ADP
dpc-4876	149	20	elisa	elisa	NOUN
dpc-4876	149	21	in	in	ADP
dpc-4876	149	22	39	39	NUM
dpc-4876	149	23	cases	case	NOUN
dpc-4876	149	24	and	and	CCONJ
dpc-4876	149	25	21	21	NUM
dpc-4876	149	26	healthy	healthy	ADJ
dpc-4876	149	27	controls	control	NOUN
dpc-4876	149	28	.	.	PUNCT
dpc-4876	150	1	the	the	DET
dpc-4876	150	2	expression	expression	NOUN
dpc-4876	150	3	levels	level	NOUN
dpc-4876	150	4	of	of	ADP
dpc-4876	150	5	the	the	DET
dpc-4876	150	6	lc3	lc3	NOUN
dpc-4876	150	7	gene	gene	NOUN
dpc-4876	150	8	were	be	AUX
dpc-4876	150	9	significantly	significantly	ADV
dpc-4876	150	10	higher	high	ADJ
dpc-4876	150	11	in	in	ADP
dpc-4876	150	12	pgh	pgh	PROPN
dpc-4876	150	13	cases	case	NOUN
dpc-4876	150	14	compared	compare	VERB
dpc-4876	150	15	to	to	ADP
dpc-4876	150	16	the	the	DET
dpc-4876	150	17	controls	control	NOUN
dpc-4876	150	18	.	.	PUNCT
dpc-4876	151	1	also	also	ADV
dpc-4876	151	2	,	,	PUNCT
dpc-4876	151	3	the	the	DET
dpc-4876	151	4	serum	serum	NOUN
dpc-4876	151	5	lc3	lc3	NOUN
dpc-4876	151	6	concentration	concentration	NOUN
dpc-4876	151	7	was	be	AUX
dpc-4876	151	8	higher	high	ADJ
dpc-4876	151	9	in	in	ADP
dpc-4876	151	10	original	original	ADJ
dpc-4876	151	11	article	article	NOUN
dpc-4876	151	12	|	|	ADV
dpc-4876	151	13	dermatol	dermatol	ADJ
dpc-4876	151	14	pract	pract	NOUN
dpc-4876	151	15	concept	concept	NOUN
dpc-4876	151	16	.	.	PUNCT
dpc-4876	152	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	152	2	7	7	NUM
dpc-4876	152	3	lc3b	lc3b	NOUN
dpc-4876	152	4	associated	associate	VERB
dpc-4876	152	5	with	with	ADP
dpc-4876	152	6	melanosomes	melanosome	NOUN
dpc-4876	152	7	does	do	AUX
dpc-4876	152	8	not	not	PART
dpc-4876	152	9	only	only	ADV
dpc-4876	152	10	affect	affect	VERB
dpc-4876	152	11	the	the	DET
dpc-4876	152	12	steady	steady	ADJ
dpc-4876	152	13	state	state	NOUN
dpc-4876	152	14	level	level	NOUN
dpc-4876	152	15	of	of	ADP
dpc-4876	152	16	melanosomes	melanosome	NOUN
dpc-4876	152	17	but	but	CCONJ
dpc-4876	152	18	also	also	ADV
dpc-4876	152	19	enables	enable	VERB
dpc-4876	152	20	their	their	PRON
dpc-4876	152	21	intracellular	intracellular	ADJ
dpc-4876	152	22	movement	movement	NOUN
dpc-4876	152	23	on	on	ADP
dpc-4876	152	24	specific	specific	ADJ
dpc-4876	152	25	microtubules	microtubule	NOUN
dpc-4876	152	26	and	and	CCONJ
dpc-4876	152	27	actin	actin	NOUN
dpc-4876	152	28	tracks	track	NOUN
dpc-4876	152	29	.	.	PUNCT
dpc-4876	153	1	therefore	therefore	ADV
dpc-4876	153	2	,	,	PUNCT
dpc-4876	153	3	the	the	DET
dpc-4876	153	4	transfer	transfer	NOUN
dpc-4876	153	5	of	of	ADP
dpc-4876	153	6	the	the	DET
dpc-4876	153	7	melanosomes	melanosome	NOUN
dpc-4876	153	8	to	to	ADP
dpc-4876	153	9	keratinocytes	keratinocyte	NOUN
dpc-4876	153	10	is	be	AUX
dpc-4876	153	11	affected	affect	VERB
dpc-4876	153	12	by	by	ADP
dpc-4876	153	13	lc3b	lc3b	NOUN
dpc-4876	153	14	knockdown	knockdown	NOUN
dpc-4876	153	15	[	[	X
dpc-4876	153	16	12	12	NUM
dpc-4876	153	17	]	]	PUNCT
dpc-4876	153	18	.	.	PUNCT
dpc-4876	154	1	the	the	DET
dpc-4876	154	2	role	role	NOUN
dpc-4876	154	3	of	of	ADP
dpc-4876	154	4	autophagy	autophagy	NOUN
dpc-4876	154	5	in	in	ADP
dpc-4876	154	6	hair	hair	NOUN
dpc-4876	154	7	physiology	physiology	NOUN
dpc-4876	154	8	has	have	AUX
dpc-4876	154	9	been	be	AUX
dpc-4876	154	10	studied	study	VERB
dpc-4876	154	11	through	through	ADP
dpc-4876	154	12	the	the	DET
dpc-4876	154	13	use	use	NOUN
dpc-4876	154	14	of	of	ADP
dpc-4876	154	15	the	the	DET
dpc-4876	154	16	organ	organ	NOUN
dpc-4876	154	17	culture	culture	NOUN
dpc-4876	154	18	of	of	ADP
dpc-4876	154	19	human	human	ADJ
dpc-4876	154	20	scalp	scalp	NOUN
dpc-4876	154	21	hair	hair	NOUN
dpc-4876	154	22	follicles	follicle	NOUN
dpc-4876	154	23	(	(	PUNCT
dpc-4876	154	24	hfs	hfs	PROPN
dpc-4876	154	25	)	)	PUNCT
dpc-4876	154	26	.	.	PUNCT
dpc-4876	155	1	in	in	ADP
dpc-4876	155	2	anagen	anagen	PROPN
dpc-4876	155	3	,	,	PUNCT
dpc-4876	155	4	the	the	DET
dpc-4876	155	5	keratinocytes	keratinocyte	NOUN
dpc-4876	155	6	of	of	ADP
dpc-4876	155	7	organ	organ	NOUN
dpc-4876	155	8	-	-	PUNCT
dpc-4876	155	9	cultured	cultured	ADJ
dpc-4876	155	10	hfs	hfs	NOUN
dpc-4876	155	11	showed	show	VERB
dpc-4876	155	12	an	an	DET
dpc-4876	155	13	active	active	ADJ
dpc-4876	155	14	autophagic	autophagic	ADJ
dpc-4876	155	15	flux	flux	NOUN
dpc-4876	155	16	as	as	SCONJ
dpc-4876	155	17	evidenced	evidence	VERB
dpc-4876	155	18	by	by	ADP
dpc-4876	155	19	the	the	DET
dpc-4876	155	20	elevation	elevation	NOUN
dpc-4876	155	21	of	of	ADP
dpc-4876	155	22	lc3b	lc3b	NOUN
dpc-4876	155	23	expression	expression	NOUN
dpc-4876	155	24	and	and	CCONJ
dpc-4876	155	25	autophagosome	autophagosome	VERB
dpc-4876	155	26	visualization	visualization	NOUN
dpc-4876	155	27	.	.	PUNCT
dpc-4876	156	1	this	this	DET
dpc-4876	156	2	autophagic	autophagic	PROPN
dpc-4876	156	3	flux	flux	NOUN
dpc-4876	156	4	changes	change	NOUN
dpc-4876	156	5	during	during	ADP
dpc-4876	156	6	catagen	catagen	NOUN
dpc-4876	156	7	.	.	PUNCT
dpc-4876	157	1	therefore	therefore	ADV
dpc-4876	157	2	,	,	PUNCT
dpc-4876	157	3	the	the	DET
dpc-4876	157	4	anti	anti	ADJ
dpc-4876	157	5	-	-	ADJ
dpc-4876	157	6	hair	hair	ADJ
dpc-4876	157	7	loss	loss	NOUN
dpc-4876	157	8	products	product	NOUN
dpc-4876	157	9	may	may	AUX
dpc-4876	157	10	prolong	prolong	VERB
dpc-4876	157	11	the	the	DET
dpc-4876	157	12	anagen	anagen	NOUN
dpc-4876	157	13	phase	phase	NOUN
dpc-4876	157	14	by	by	ADP
dpc-4876	157	15	enhancing	enhance	VERB
dpc-4876	157	16	hfs	hfs	NOUN
dpc-4876	157	17	autophagy	autophagy	NOUN
dpc-4876	157	18	[	[	X
dpc-4876	157	19	25	25	NUM
dpc-4876	157	20	]	]	PUNCT
dpc-4876	157	21	.	.	PUNCT
dpc-4876	158	1	the	the	DET
dpc-4876	158	2	current	current	ADJ
dpc-4876	158	3	study	study	NOUN
dpc-4876	158	4	showed	show	VERB
dpc-4876	158	5	a	a	DET
dpc-4876	158	6	significant	significant	ADJ
dpc-4876	158	7	positive	positive	ADJ
dpc-4876	158	8	correlation	correlation	NOUN
dpc-4876	158	9	between	between	ADP
dpc-4876	158	10	lc3	lc3	NOUN
dpc-4876	158	11	expression	expression	NOUN
dpc-4876	158	12	and	and	CCONJ
dpc-4876	158	13	concentration	concentration	NOUN
dpc-4876	158	14	by	by	ADP
dpc-4876	158	15	elisa	elisa	NOUN
dpc-4876	158	16	among	among	ADP
dpc-4876	158	17	controls	control	NOUN
dpc-4876	158	18	as	as	ADV
dpc-4876	158	19	well	well	ADV
dpc-4876	158	20	as	as	ADP
dpc-4876	158	21	pgh	pgh	PROPN
dpc-4876	158	22	cases	case	NOUN
dpc-4876	158	23	.	.	PUNCT
dpc-4876	159	1	after	after	ADP
dpc-4876	159	2	adjusting	adjust	VERB
dpc-4876	159	3	for	for	ADP
dpc-4876	159	4	all	all	DET
dpc-4876	159	5	factors	factor	NOUN
dpc-4876	159	6	,	,	PUNCT
dpc-4876	159	7	the	the	DET
dpc-4876	159	8	only	only	ADJ
dpc-4876	159	9	predictor	predictor	NOUN
dpc-4876	159	10	of	of	ADP
dpc-4876	159	11	pgh	pgh	PROPN
dpc-4876	159	12	was	be	AUX
dpc-4876	159	13	lc3	lc3	NOUN
dpc-4876	159	14	gene	gene	NOUN
dpc-4876	159	15	expression	expression	NOUN
dpc-4876	159	16	.	.	PUNCT
dpc-4876	160	1	in	in	ADP
dpc-4876	160	2	other	other	ADJ
dpc-4876	160	3	words	word	NOUN
dpc-4876	160	4	,	,	PUNCT
dpc-4876	160	5	with	with	ADP
dpc-4876	160	6	a	a	DET
dpc-4876	160	7	one	one	NUM
dpc-4876	160	8	-	-	PUNCT
dpc-4876	160	9	point	point	NOUN
dpc-4876	160	10	increase	increase	NOUN
dpc-4876	160	11	in	in	ADP
dpc-4876	160	12	the	the	DET
dpc-4876	160	13	lc3	lc3	NOUN
dpc-4876	160	14	expression	expression	NOUN
dpc-4876	160	15	,	,	PUNCT
dpc-4876	160	16	there	there	PRON
dpc-4876	160	17	was	be	VERB
dpc-4876	160	18	a	a	DET
dpc-4876	160	19	six	six	NUM
dpc-4876	160	20	-	-	PUNCT
dpc-4876	160	21	time	time	NOUN
dpc-4876	160	22	increase	increase	NOUN
dpc-4876	160	23	in	in	ADP
dpc-4876	160	24	the	the	DET
dpc-4876	160	25	risk	risk	NOUN
dpc-4876	160	26	of	of	ADP
dpc-4876	160	27	having	have	VERB
dpc-4876	160	28	pgh	pgh	PROPN
dpc-4876	160	29	.	.	PUNCT
dpc-4876	161	1	family	family	NOUN
dpc-4876	161	2	history	history	NOUN
dpc-4876	161	3	and	and	CCONJ
dpc-4876	161	4	age	age	NOUN
dpc-4876	161	5	at	at	ADP
dpc-4876	161	6	onset	onset	NOUN
dpc-4876	161	7	of	of	ADP
dpc-4876	161	8	pgh	pgh	PROPN
dpc-4876	161	9	are	be	AUX
dpc-4876	161	10	important	important	ADJ
dpc-4876	161	11	risk	risk	NOUN
dpc-4876	161	12	factors	factor	NOUN
dpc-4876	161	13	associated	associate	VERB
dpc-4876	161	14	with	with	ADP
dpc-4876	161	15	pgh	pgh	PROPN
dpc-4876	161	16	development	development	NOUN
dpc-4876	162	1	[	[	X
dpc-4876	162	2	26	26	NUM
dpc-4876	162	3	]	]	PUNCT
dpc-4876	162	4	.	.	PUNCT
dpc-4876	163	1	in	in	ADP
dpc-4876	163	2	a	a	DET
dpc-4876	163	3	recent	recent	ADJ
dpc-4876	163	4	meta	meta	ADJ
dpc-4876	163	5	-	-	PUNCT
dpc-4876	163	6	analysis	analysis	NOUN
dpc-4876	163	7	,	,	PUNCT
dpc-4876	163	8	several	several	ADJ
dpc-4876	163	9	risk	risk	NOUN
dpc-4876	163	10	factors	factor	NOUN
dpc-4876	163	11	were	be	AUX
dpc-4876	163	12	associated	associate	VERB
dpc-4876	163	13	with	with	ADP
dpc-4876	163	14	pgh	pgh	PROPN
dpc-4876	163	15	,	,	PUNCT
dpc-4876	163	16	including	include	VERB
dpc-4876	163	17	smoking	smoking	NOUN
dpc-4876	163	18	,	,	PUNCT
dpc-4876	163	19	mineral	mineral	NOUN
dpc-4876	163	20	deficiency	deficiency	NOUN
dpc-4876	163	21	(	(	PUNCT
dpc-4876	163	22	low	low	ADJ
dpc-4876	163	23	serum	serum	NOUN
dpc-4876	163	24	iron	iron	NOUN
dpc-4876	163	25	and	and	CCONJ
dpc-4876	163	26	calcium	calcium	NOUN
dpc-4876	163	27	)	)	PUNCT
dpc-4876	163	28	,	,	PUNCT
dpc-4876	163	29	and	and	CCONJ
dpc-4876	163	30	vitamin	vitamin	NOUN
dpc-4876	163	31	deficiency	deficiency	NOUN
dpc-4876	163	32	(	(	PUNCT
dpc-4876	163	33	b7	b7	PROPN
dpc-4876	163	34	,	,	PUNCT
dpc-4876	163	35	b12	b12	NOUN
dpc-4876	163	36	,	,	PUNCT
dpc-4876	163	37	and	and	CCONJ
dpc-4876	163	38	folic	folic	ADJ
dpc-4876	163	39	acid	acid	NOUN
dpc-4876	163	40	)	)	PUNCT
dpc-4876	164	1	[	[	X
dpc-4876	164	2	27	27	NUM
dpc-4876	164	3	]	]	PUNCT
dpc-4876	164	4	.	.	PUNCT
dpc-4876	165	1	the	the	DET
dpc-4876	165	2	current	current	ADJ
dpc-4876	165	3	study	study	NOUN
dpc-4876	165	4	has	have	VERB
dpc-4876	165	5	several	several	ADJ
dpc-4876	165	6	limitations	limitation	NOUN
dpc-4876	165	7	.	.	PUNCT
dpc-4876	166	1	the	the	DET
dpc-4876	166	2	first	first	ADJ
dpc-4876	166	3	is	be	AUX
dpc-4876	166	4	the	the	DET
dpc-4876	166	5	small	small	ADJ
dpc-4876	166	6	sample	sample	NOUN
dpc-4876	166	7	size	size	NOUN
dpc-4876	166	8	of	of	ADP
dpc-4876	166	9	the	the	DET
dpc-4876	166	10	included	include	VERB
dpc-4876	166	11	pgh	pgh	PROPN
dpc-4876	166	12	cases	case	NOUN
dpc-4876	166	13	and	and	CCONJ
dpc-4876	166	14	the	the	DET
dpc-4876	166	15	healthy	healthy	ADJ
dpc-4876	166	16	controls	control	NOUN
dpc-4876	166	17	.	.	PUNCT
dpc-4876	167	1	investigations	investigation	NOUN
dpc-4876	167	2	of	of	ADP
dpc-4876	167	3	patients	patient	NOUN
dpc-4876	167	4	and	and	CCONJ
dpc-4876	167	5	controls	control	NOUN
dpc-4876	167	6	for	for	ADP
dpc-4876	167	7	nutritional	nutritional	ADJ
dpc-4876	167	8	deficiencies	deficiency	NOUN
dpc-4876	167	9	such	such	ADJ
dpc-4876	167	10	as	as	ADP
dpc-4876	167	11	mineral	mineral	NOUN
dpc-4876	167	12	deficiency	deficiency	NOUN
dpc-4876	167	13	and	and	CCONJ
dpc-4876	167	14	vitamin	vitamin	NOUN
dpc-4876	167	15	deficiency	deficiency	NOUN
dpc-4876	167	16	are	be	AUX
dpc-4876	167	17	needed	need	VERB
dpc-4876	167	18	to	to	PART
dpc-4876	167	19	decrease	decrease	VERB
dpc-4876	167	20	bias	bias	NOUN
dpc-4876	167	21	.	.	PUNCT
dpc-4876	168	1	the	the	DET
dpc-4876	168	2	second	second	ADJ
dpc-4876	168	3	is	be	AUX
dpc-4876	168	4	that	that	SCONJ
dpc-4876	168	5	this	this	DET
dpc-4876	168	6	autophagic	autophagic	ADJ
dpc-4876	168	7	evaluation	evaluation	NOUN
dpc-4876	168	8	does	do	AUX
dpc-4876	168	9	not	not	PART
dpc-4876	168	10	reflect	reflect	VERB
dpc-4876	168	11	the	the	DET
dpc-4876	168	12	autophagic	autophagic	ADJ
dpc-4876	168	13	flux	flux	NOUN
dpc-4876	168	14	.	.	PUNCT
dpc-4876	169	1	the	the	DET
dpc-4876	169	2	transmission	transmission	NOUN
dpc-4876	169	3	electron	electron	NOUN
dpc-4876	169	4	microscopic	microscopic	ADJ
dpc-4876	169	5	visualization	visualization	NOUN
dpc-4876	169	6	of	of	ADP
dpc-4876	169	7	autophagosomes	autophagosome	NOUN
dpc-4876	169	8	is	be	AUX
dpc-4876	169	9	considered	consider	VERB
dpc-4876	169	10	the	the	DET
dpc-4876	169	11	gold	gold	ADJ
dpc-4876	169	12	standard	standard	NOUN
dpc-4876	169	13	for	for	ADP
dpc-4876	169	14	autophagy	autophagy	ADJ
dpc-4876	169	15	diagnosis	diagnosis	NOUN
dpc-4876	169	16	.	.	PUNCT
dpc-4876	170	1	also	also	ADV
dpc-4876	170	2	,	,	PUNCT
dpc-4876	170	3	the	the	DET
dpc-4876	170	4	relationship	relationship	NOUN
dpc-4876	170	5	between	between	ADP
dpc-4876	170	6	autophagy	autophagy	ADJ
dpc-4876	170	7	and	and	CCONJ
dpc-4876	170	8	oxidative	oxidative	ADJ
dpc-4876	170	9	stress	stress	NOUN
dpc-4876	170	10	was	be	AUX
dpc-4876	170	11	not	not	PART
dpc-4876	170	12	evaluated	evaluate	VERB
dpc-4876	170	13	in	in	ADP
dpc-4876	170	14	pgh	pgh	PROPN
dpc-4876	170	15	,	,	PUNCT
dpc-4876	170	16	especially	especially	ADV
dpc-4876	170	17	since	since	SCONJ
dpc-4876	170	18	oxidative	oxidative	ADJ
dpc-4876	170	19	stress	stress	NOUN
dpc-4876	170	20	has	have	VERB
dpc-4876	170	21	an	an	DET
dpc-4876	170	22	important	important	ADJ
dpc-4876	170	23	role	role	NOUN
dpc-4876	170	24	in	in	ADP
dpc-4876	170	25	pgh	pgh	PROPN
dpc-4876	171	1	[	[	X
dpc-4876	171	2	28	28	NUM
dpc-4876	171	3	]	]	PUNCT
dpc-4876	171	4	.	.	PUNCT
dpc-4876	172	1	finally	finally	ADV
dpc-4876	172	2	,	,	PUNCT
dpc-4876	172	3	the	the	DET
dpc-4876	172	4	current	current	ADJ
dpc-4876	172	5	study	study	NOUN
dpc-4876	172	6	could	could	AUX
dpc-4876	172	7	not	not	PART
dpc-4876	172	8	establish	establish	VERB
dpc-4876	172	9	either	either	CCONJ
dpc-4876	172	10	the	the	DET
dpc-4876	172	11	cause	cause	NOUN
dpc-4876	172	12	or	or	CCONJ
dpc-4876	172	13	effect	effect	VERB
dpc-4876	172	14	relationship	relationship	NOUN
dpc-4876	172	15	between	between	ADP
dpc-4876	172	16	hair	hair	NOUN
dpc-4876	172	17	graying	gray	VERB
dpc-4876	172	18	and	and	CCONJ
dpc-4876	172	19	elevated	elevated	ADJ
dpc-4876	172	20	levels	level	NOUN
dpc-4876	172	21	for	for	ADP
dpc-4876	172	22	the	the	DET
dpc-4876	172	23	studied	study	VERB
dpc-4876	172	24	lc3	lc3	NOUN
dpc-4876	172	25	gene	gene	NOUN
dpc-4876	172	26	product	product	NOUN
dpc-4876	172	27	,	,	PUNCT
dpc-4876	172	28	but	but	CCONJ
dpc-4876	172	29	only	only	ADV
dpc-4876	172	30	showed	show	VERB
dpc-4876	172	31	an	an	DET
dpc-4876	172	32	association	association	NOUN
dpc-4876	172	33	.	.	PUNCT
dpc-4876	173	1	a	a	DET
dpc-4876	173	2	multicenter	multicenter	ADJ
dpc-4876	173	3	case	case	NOUN
dpc-4876	173	4	-	-	PUNCT
dpc-4876	173	5	control	control	NOUN
dpc-4876	173	6	study	study	NOUN
dpc-4876	173	7	with	with	ADP
dpc-4876	173	8	a	a	DET
dpc-4876	173	9	larger	large	ADJ
dpc-4876	173	10	sample	sample	NOUN
dpc-4876	173	11	size	size	NOUN
dpc-4876	173	12	is	be	AUX
dpc-4876	173	13	needed	need	VERB
dpc-4876	173	14	to	to	PART
dpc-4876	173	15	evaluate	evaluate	VERB
dpc-4876	173	16	serum	serum	NOUN
dpc-4876	173	17	and	and	CCONJ
dpc-4876	173	18	gene	gene	NOUN
dpc-4876	173	19	expression	expression	NOUN
dpc-4876	173	20	of	of	ADP
dpc-4876	173	21	several	several	ADJ
dpc-4876	173	22	autophagic	autophagic	ADJ
dpc-4876	173	23	markers	marker	NOUN
dpc-4876	173	24	including	include	VERB
dpc-4876	173	25	lc3	lc3	NOUN
dpc-4876	173	26	,	,	PUNCT
dpc-4876	173	27	p62	p62	NOUN
dpc-4876	173	28	,	,	PUNCT
dpc-4876	173	29	and	and	CCONJ
dpc-4876	173	30	beclin	beclin	NOUN
dpc-4876	173	31	together	together	ADV
dpc-4876	173	32	with	with	ADP
dpc-4876	173	33	autophagosome	autophagosome	VERB
dpc-4876	173	34	visualization	visualization	NOUN
dpc-4876	173	35	with	with	ADP
dpc-4876	173	36	the	the	DET
dpc-4876	173	37	transmission	transmission	NOUN
dpc-4876	173	38	electron	electron	NOUN
dpc-4876	173	39	microscope	microscope	NOUN
dpc-4876	173	40	.	.	PUNCT
dpc-4876	174	1	also	also	ADV
dpc-4876	174	2	,	,	PUNCT
dpc-4876	174	3	autophagic	autophagic	ADJ
dpc-4876	174	4	manipulation	manipulation	NOUN
dpc-4876	174	5	might	might	AUX
dpc-4876	174	6	be	be	AUX
dpc-4876	174	7	a	a	DET
dpc-4876	174	8	potential	potential	ADJ
dpc-4876	174	9	therapeutic	therapeutic	ADJ
dpc-4876	174	10	modality	modality	NOUN
dpc-4876	174	11	for	for	ADP
dpc-4876	174	12	the	the	DET
dpc-4876	174	13	treatment	treatment	NOUN
dpc-4876	174	14	of	of	ADP
dpc-4876	174	15	pgh	pgh	PROPN
dpc-4876	174	16	.	.	PUNCT
dpc-4876	175	1	study	study	PROPN
dpc-4876	175	2	approval	approval	NOUN
dpc-4876	175	3	statement	statement	NOUN
dpc-4876	175	4	:	:	PUNCT
dpc-4876	175	5	this	this	DET
dpc-4876	175	6	study	study	NOUN
dpc-4876	175	7	was	be	AUX
dpc-4876	175	8	performed	perform	VERB
dpc-4876	175	9	in	in	ADP
dpc-4876	175	10	line	line	NOUN
dpc-4876	175	11	with	with	ADP
dpc-4876	175	12	the	the	DET
dpc-4876	175	13	principles	principle	NOUN
dpc-4876	175	14	of	of	ADP
dpc-4876	175	15	the	the	DET
dpc-4876	175	16	declaration	declaration	NOUN
dpc-4876	175	17	of	of	ADP
dpc-4876	175	18	helsinki	helsinki	PROPN
dpc-4876	175	19	.	.	PUNCT
dpc-4876	176	1	approval	approval	NOUN
dpc-4876	176	2	was	be	AUX
dpc-4876	176	3	granted	grant	VERB
dpc-4876	176	4	by	by	ADP
dpc-4876	176	5	the	the	DET
dpc-4876	176	6	medical	medical	ADJ
dpc-4876	176	7	research	research	PROPN
dpc-4876	176	8	ethics	ethic	NOUN
dpc-4876	176	9	committee	committee	NOUN
dpc-4876	176	10	at	at	ADP
dpc-4876	176	11	the	the	DET
dpc-4876	176	12	faculty	faculty	NOUN
dpc-4876	176	13	of	of	ADP
dpc-4876	176	14	medicine	medicine	NOUN
dpc-4876	176	15	(	(	PUNCT
dpc-4876	176	16	irb	irb	NOUN
dpc-4876	176	17	;	;	PUNCT
dpc-4876	176	18	soh	soh	NOUN
dpc-4876	176	19	-	-	PUNCT
dpc-4876	176	20	med-22	med-22	NUM
dpc-4876	176	21	-	-	PUNCT
dpc-4876	176	22	11	11	NUM
dpc-4876	176	23	-	-	SYM
dpc-4876	176	24	16	16	NUM
dpc-4876	176	25	)	)	PUNCT
dpc-4876	176	26	.	.	PUNCT
dpc-4876	177	1	consent	consent	NOUN
dpc-4876	177	2	to	to	PART
dpc-4876	177	3	participate	participate	VERB
dpc-4876	177	4	statement	statement	NOUN
dpc-4876	177	5	:	:	PUNCT
dpc-4876	177	6	informed	inform	VERB
dpc-4876	177	7	consent	consent	NOUN
dpc-4876	177	8	was	be	AUX
dpc-4876	177	9	obtained	obtain	VERB
dpc-4876	177	10	from	from	ADP
dpc-4876	177	11	all	all	DET
dpc-4876	177	12	participants	participant	NOUN
dpc-4876	177	13	included	include	VERB
dpc-4876	177	14	in	in	ADP
dpc-4876	177	15	the	the	DET
dpc-4876	177	16	study	study	NOUN
dpc-4876	177	17	.	.	PUNCT
dpc-4876	178	1	pgh	pgh	NOUN
dpc-4876	178	2	cases	case	NOUN
dpc-4876	178	3	with	with	ADP
dpc-4876	178	4	disease	disease	NOUN
dpc-4876	178	5	duration	duration	NOUN
dpc-4876	178	6	≤7	≤7	PROPN
dpc-4876	178	7	years	year	NOUN
dpc-4876	178	8	.	.	PUNCT
dpc-4876	179	1	in	in	ADP
dpc-4876	179	2	addition	addition	NOUN
dpc-4876	179	3	,	,	PUNCT
dpc-4876	179	4	the	the	DET
dpc-4876	179	5	serum	serum	NOUN
dpc-4876	179	6	lc3	lc3	NOUN
dpc-4876	179	7	concentration	concentration	NOUN
dpc-4876	179	8	was	be	AUX
dpc-4876	179	9	significantly	significantly	ADV
dpc-4876	179	10	higher	high	ADJ
dpc-4876	179	11	in	in	ADP
dpc-4876	179	12	pgh	pgh	PROPN
dpc-4876	179	13	cases	case	NOUN
dpc-4876	179	14	with	with	ADP
dpc-4876	179	15	an	an	DET
dpc-4876	179	16	age	age	NOUN
dpc-4876	179	17	at	at	ADP
dpc-4876	179	18	onset	onset	NOUN
dpc-4876	179	19	of	of	ADP
dpc-4876	179	20	>	>	SYM
dpc-4876	179	21	20	20	NUM
dpc-4876	179	22	years	year	NOUN
dpc-4876	179	23	old	old	ADJ
dpc-4876	179	24	and	and	CCONJ
dpc-4876	179	25	significantly	significantly	ADV
dpc-4876	179	26	higher	high	ADJ
dpc-4876	179	27	in	in	ADP
dpc-4876	179	28	pgh	pgh	PROPN
dpc-4876	179	29	cases	case	NOUN
dpc-4876	179	30	with	with	ADP
dpc-4876	179	31	disease	disease	NOUN
dpc-4876	179	32	duration	duration	NOUN
dpc-4876	179	33	≤7	≤7	PROPN
dpc-4876	179	34	years	year	NOUN
dpc-4876	179	35	.	.	PUNCT
dpc-4876	180	1	in	in	ADP
dpc-4876	180	2	the	the	DET
dpc-4876	180	3	current	current	ADJ
dpc-4876	180	4	study	study	NOUN
dpc-4876	180	5	,	,	PUNCT
dpc-4876	180	6	pgh	pgh	PROPN
dpc-4876	180	7	patients	patient	NOUN
dpc-4876	180	8	showed	show	VERB
dpc-4876	180	9	significantly	significantly	ADV
dpc-4876	180	10	higher	high	ADJ
dpc-4876	180	11	lc3	lc3	NOUN
dpc-4876	180	12	gene	gene	NOUN
dpc-4876	180	13	expression	expression	NOUN
dpc-4876	180	14	(	(	PUNCT
dpc-4876	180	15	although	although	SCONJ
dpc-4876	180	16	the	the	DET
dpc-4876	180	17	non	non	ADJ
dpc-4876	180	18	-	-	ADJ
dpc-4876	180	19	significant	significant	ADJ
dpc-4876	180	20	high	high	ADJ
dpc-4876	180	21	serum	serum	NOUN
dpc-4876	180	22	lc3	lc3	NOUN
dpc-4876	180	23	)	)	PUNCT
dpc-4876	180	24	as	as	SCONJ
dpc-4876	180	25	compared	compare	VERB
dpc-4876	180	26	to	to	ADP
dpc-4876	180	27	controls	control	NOUN
dpc-4876	180	28	.	.	PUNCT
dpc-4876	181	1	this	this	PRON
dpc-4876	181	2	may	may	AUX
dpc-4876	181	3	be	be	AUX
dpc-4876	181	4	explained	explain	VERB
dpc-4876	181	5	by	by	ADP
dpc-4876	181	6	the	the	DET
dpc-4876	181	7	usual	usual	ADJ
dpc-4876	181	8	poor	poor	ADJ
dpc-4876	181	9	correlation	correlation	NOUN
dpc-4876	181	10	between	between	ADP
dpc-4876	181	11	mrna	mrna	PROPN
dpc-4876	181	12	and	and	CCONJ
dpc-4876	181	13	protein	protein	NOUN
dpc-4876	181	14	concentrations	concentration	NOUN
dpc-4876	181	15	[	[	X
dpc-4876	181	16	19	19	NUM
dpc-4876	181	17	]	]	PUNCT
dpc-4876	181	18	.	.	PUNCT
dpc-4876	182	1	furthermore	furthermore	ADV
dpc-4876	182	2	,	,	PUNCT
dpc-4876	182	3	it	it	PRON
dpc-4876	182	4	is	be	AUX
dpc-4876	182	5	unknown	unknown	ADJ
dpc-4876	182	6	how	how	SCONJ
dpc-4876	182	7	much	much	ADJ
dpc-4876	182	8	of	of	ADP
dpc-4876	182	9	the	the	DET
dpc-4876	182	10	relative	relative	ADJ
dpc-4876	182	11	concentration	concentration	NOUN
dpc-4876	182	12	of	of	ADP
dpc-4876	182	13	the	the	DET
dpc-4876	182	14	mrna	mrna	NOUN
dpc-4876	182	15	level	level	NOUN
dpc-4876	182	16	is	be	AUX
dpc-4876	182	17	translated	translate	VERB
dpc-4876	182	18	to	to	ADP
dpc-4876	182	19	the	the	DET
dpc-4876	182	20	protein	protein	NOUN
dpc-4876	182	21	level	level	NOUN
dpc-4876	182	22	[	[	X
dpc-4876	182	23	20	20	NUM
dpc-4876	182	24	]	]	PUNCT
dpc-4876	182	25	.	.	PUNCT
dpc-4876	183	1	moreover	moreover	ADV
dpc-4876	183	2	,	,	PUNCT
dpc-4876	183	3	there	there	PRON
dpc-4876	183	4	is	be	VERB
dpc-4876	183	5	great	great	ADJ
dpc-4876	183	6	variability	variability	NOUN
dpc-4876	183	7	in	in	ADP
dpc-4876	183	8	the	the	DET
dpc-4876	183	9	rate	rate	NOUN
dpc-4876	183	10	of	of	ADP
dpc-4876	183	11	production	production	NOUN
dpc-4876	183	12	and	and	CCONJ
dpc-4876	183	13	degradation	degradation	NOUN
dpc-4876	183	14	of	of	ADP
dpc-4876	183	15	proteins	protein	NOUN
dpc-4876	183	16	irrespective	irrespective	ADV
dpc-4876	183	17	of	of	ADP
dpc-4876	183	18	the	the	DET
dpc-4876	183	19	corresponding	corresponding	ADJ
dpc-4876	183	20	mrna	mrna	PROPN
dpc-4876	183	21	levels	level	NOUN
dpc-4876	183	22	[	[	X
dpc-4876	183	23	10	10	NUM
dpc-4876	183	24	]	]	PUNCT
dpc-4876	183	25	.	.	PUNCT
dpc-4876	184	1	a	a	DET
dpc-4876	184	2	clinical	clinical	ADJ
dpc-4876	184	3	study	study	NOUN
dpc-4876	184	4	[	[	X
dpc-4876	184	5	21	21	NUM
dpc-4876	184	6	]	]	PUNCT
dpc-4876	184	7	compared	compare	VERB
dpc-4876	184	8	the	the	DET
dpc-4876	184	9	hypopigmented	hypopigmente	VERB
dpc-4876	184	10	macules	macule	NOUN
dpc-4876	184	11	of	of	ADP
dpc-4876	184	12	tuberous	tuberous	ADJ
dpc-4876	184	13	sclerosis	sclerosis	NOUN
dpc-4876	184	14	complex	complex	NOUN
dpc-4876	184	15	(	(	PUNCT
dpc-4876	184	16	tsc	tsc	PROPN
dpc-4876	184	17	)	)	PUNCT
dpc-4876	184	18	with	with	ADP
dpc-4876	184	19	normal	normal	ADJ
dpc-4876	184	20	skin	skin	NOUN
dpc-4876	184	21	as	as	SCONJ
dpc-4876	184	22	regards	regard	VERB
dpc-4876	184	23	the	the	DET
dpc-4876	184	24	possible	possible	ADJ
dpc-4876	184	25	role	role	NOUN
dpc-4876	184	26	of	of	ADP
dpc-4876	184	27	autophagy	autophagy	NOUN
dpc-4876	184	28	.	.	PUNCT
dpc-4876	185	1	the	the	DET
dpc-4876	185	2	melanocytes	melanocyte	NOUN
dpc-4876	185	3	of	of	ADP
dpc-4876	185	4	the	the	DET
dpc-4876	185	5	tschypopigmented	tschypopigmente	VERB
dpc-4876	185	6	macules	macule	NOUN
dpc-4876	185	7	showed	show	VERB
dpc-4876	185	8	dysregulation	dysregulation	NOUN
dpc-4876	185	9	of	of	ADP
dpc-4876	185	10	autophagy	autophagy	NOUN
dpc-4876	185	11	with	with	ADP
dpc-4876	185	12	increased	increase	VERB
dpc-4876	185	13	lc3	lc3	NOUN
dpc-4876	185	14	expression	expression	NOUN
dpc-4876	185	15	and	and	CCONJ
dpc-4876	185	16	p62	p62	NOUN
dpc-4876	185	17	accumulation	accumulation	NOUN
dpc-4876	185	18	,	,	PUNCT
dpc-4876	185	19	which	which	PRON
dpc-4876	185	20	is	be	AUX
dpc-4876	185	21	one	one	NUM
dpc-4876	185	22	of	of	ADP
dpc-4876	185	23	the	the	DET
dpc-4876	185	24	autophagic	autophagic	ADJ
dpc-4876	185	25	substrates	substrate	NOUN
dpc-4876	185	26	[	[	X
dpc-4876	185	27	21	21	NUM
dpc-4876	185	28	]	]	PUNCT
dpc-4876	185	29	.	.	PUNCT
dpc-4876	186	1	a	a	DET
dpc-4876	186	2	recent	recent	ADJ
dpc-4876	186	3	in	in	ADP
dpc-4876	186	4	vitro	vitro	X
dpc-4876	186	5	study	study	NOUN
dpc-4876	186	6	[	[	X
dpc-4876	186	7	22	22	NUM
dpc-4876	186	8	]	]	PUNCT
dpc-4876	186	9	evaluated	evaluate	VERB
dpc-4876	186	10	the	the	DET
dpc-4876	186	11	effect	effect	NOUN
dpc-4876	186	12	of	of	ADP
dpc-4876	186	13	a	a	DET
dpc-4876	186	14	synthetic	synthetic	ADJ
dpc-4876	186	15	autophagy	autophagy	NOUN
dpc-4876	186	16	inducer	inducer	NOUN
dpc-4876	186	17	ptpd-12	ptpd-12	PROPN
dpc-4876	186	18	on	on	ADP
dpc-4876	186	19	human	human	ADJ
dpc-4876	186	20	melanocytes	melanocyte	NOUN
dpc-4876	186	21	and	and	CCONJ
dpc-4876	186	22	keratinocytes	keratinocyte	NOUN
dpc-4876	186	23	containing	contain	VERB
dpc-4876	186	24	melanosomes	melanosome	NOUN
dpc-4876	186	25	.	.	PUNCT
dpc-4876	187	1	the	the	DET
dpc-4876	187	2	induction	induction	NOUN
dpc-4876	187	3	of	of	ADP
dpc-4876	187	4	the	the	DET
dpc-4876	187	5	autophagic	autophagic	PROPN
dpc-4876	187	6	flux	flux	NOUN
dpc-4876	187	7	led	lead	VERB
dpc-4876	187	8	to	to	ADP
dpc-4876	187	9	increased	increase	VERB
dpc-4876	187	10	degradation	degradation	NOUN
dpc-4876	187	11	of	of	ADP
dpc-4876	187	12	melanosomes	melanosome	NOUN
dpc-4876	187	13	,	,	PUNCT
dpc-4876	187	14	with	with	ADP
dpc-4876	187	15	visible	visible	ADJ
dpc-4876	187	16	lightening	lightening	NOUN
dpc-4876	187	17	of	of	ADP
dpc-4876	187	18	melanocyte	melanocyte	NOUN
dpc-4876	187	19	and	and	CCONJ
dpc-4876	187	20	keratinocytes	keratinocyte	VERB
dpc-4876	187	21	cell	cell	NOUN
dpc-4876	187	22	pellets	pellet	NOUN
dpc-4876	187	23	.	.	PUNCT
dpc-4876	188	1	however	however	ADV
dpc-4876	188	2	,	,	PUNCT
dpc-4876	188	3	the	the	DET
dpc-4876	188	4	autophagic	autophagic	ADJ
dpc-4876	188	5	flux	flux	NOUN
dpc-4876	188	6	inhibition	inhibition	NOUN
dpc-4876	188	7	by	by	ADP
dpc-4876	188	8	chloroquine	chloroquine	NOUN
dpc-4876	188	9	led	lead	VERB
dpc-4876	188	10	to	to	ADP
dpc-4876	188	11	a	a	DET
dpc-4876	188	12	decreased	decrease	VERB
dpc-4876	188	13	degradation	degradation	NOUN
dpc-4876	188	14	of	of	ADP
dpc-4876	188	15	melanosomes	melanosome	NOUN
dpc-4876	188	16	leading	lead	VERB
dpc-4876	188	17	to	to	ADP
dpc-4876	188	18	return	return	NOUN
dpc-4876	188	19	of	of	ADP
dpc-4876	188	20	the	the	DET
dpc-4876	188	21	normal	normal	ADJ
dpc-4876	188	22	melanogenesis	melanogenesis	NOUN
dpc-4876	188	23	pathway	pathway	NOUN
dpc-4876	188	24	.	.	PUNCT
dpc-4876	189	1	this	this	PRON
dpc-4876	189	2	suggests	suggest	VERB
dpc-4876	189	3	the	the	DET
dpc-4876	189	4	complex	complex	ADJ
dpc-4876	189	5	role	role	NOUN
dpc-4876	189	6	of	of	ADP
dpc-4876	189	7	autophagy	autophagy	NOUN
dpc-4876	189	8	in	in	ADP
dpc-4876	189	9	melanocyte	melanocyte	NOUN
dpc-4876	189	10	biology	biology	NOUN
dpc-4876	189	11	and	and	CCONJ
dpc-4876	189	12	melanogenesis[22	melanogenesis[22	NOUN
dpc-4876	189	13	]	]	PUNCT
dpc-4876	189	14	.	.	PUNCT
dpc-4876	190	1	atg7	atg7	PROPN
dpc-4876	190	2	gene	gene	NOUN
dpc-4876	190	3	deletion	deletion	NOUN
dpc-4876	190	4	in	in	ADP
dpc-4876	190	5	melanocytes	melanocyte	NOUN
dpc-4876	190	6	suppressed	suppress	VERB
dpc-4876	190	7	lc3b	lc3b	NOUN
dpc-4876	190	8	expression	expression	NOUN
dpc-4876	190	9	and	and	CCONJ
dpc-4876	190	10	induced	induce	VERB
dpc-4876	190	11	mild	mild	ADJ
dpc-4876	190	12	hypopigmentation	hypopigmentation	NOUN
dpc-4876	190	13	in	in	ADP
dpc-4876	190	14	mice	mouse	NOUN
dpc-4876	190	15	skin	skin	NOUN
dpc-4876	190	16	[	[	X
dpc-4876	190	17	23	23	NUM
dpc-4876	190	18	]	]	PUNCT
dpc-4876	190	19	.	.	PUNCT
dpc-4876	191	1	the	the	DET
dpc-4876	191	2	melanin	melanin	NOUN
dpc-4876	191	3	content	content	NOUN
dpc-4876	191	4	of	of	ADP
dpc-4876	191	5	the	the	DET
dpc-4876	191	6	hair	hair	NOUN
dpc-4876	191	7	of	of	ADP
dpc-4876	191	8	atg7	atg7	PROPN
dpc-4876	191	9	deficient	deficient	ADJ
dpc-4876	191	10	mice	mouse	NOUN
dpc-4876	191	11	was	be	AUX
dpc-4876	191	12	reduced	reduce	VERB
dpc-4876	191	13	by	by	ADP
dpc-4876	191	14	10	10	NUM
dpc-4876	191	15	-	-	SYM
dpc-4876	191	16	15	15	NUM
dpc-4876	191	17	%	%	NOUN
dpc-4876	191	18	as	as	ADP
dpc-4876	191	19	compared	compare	VERB
dpc-4876	191	20	with	with	ADP
dpc-4876	191	21	the	the	DET
dpc-4876	191	22	control	control	NOUN
dpc-4876	191	23	.	.	PUNCT
dpc-4876	192	1	the	the	DET
dpc-4876	192	2	atg7	atg7	PROPN
dpc-4876	192	3	deficient	deficient	ADJ
dpc-4876	192	4	melanocytes	melanocyte	NOUN
dpc-4876	192	5	showed	show	VERB
dpc-4876	192	6	oxidative	oxidative	ADJ
dpc-4876	192	7	stressinduced	stressinduced	ADJ
dpc-4876	192	8	damage	damage	NOUN
dpc-4876	192	9	with	with	ADP
dpc-4876	192	10	premature	premature	ADJ
dpc-4876	192	11	growth	growth	NOUN
dpc-4876	192	12	arrest	arrest	NOUN
dpc-4876	192	13	.	.	PUNCT
dpc-4876	193	1	more	more	ADV
dpc-4876	193	2	interestingly	interestingly	ADV
dpc-4876	193	3	,	,	PUNCT
dpc-4876	193	4	in	in	ADP
dpc-4876	193	5	vitro	vitro	X
dpc-4876	193	6	cultures	culture	NOUN
dpc-4876	193	7	of	of	ADP
dpc-4876	193	8	melanocytes	melanocyte	NOUN
dpc-4876	193	9	from	from	ADP
dpc-4876	193	10	atg7	atg7	PROPN
dpc-4876	193	11	deficient	deficient	ADJ
dpc-4876	193	12	mice	mouse	NOUN
dpc-4876	193	13	and	and	CCONJ
dpc-4876	193	14	control	control	NOUN
dpc-4876	194	1	demonstrate	demonstrate	VERB
dpc-4876	194	2	an	an	DET
dpc-4876	194	3	equal	equal	ADJ
dpc-4876	194	4	amount	amount	NOUN
dpc-4876	194	5	of	of	ADP
dpc-4876	194	6	melanin	melanin	NOUN
dpc-4876	194	7	per	per	ADP
dpc-4876	194	8	cell	cell	NOUN
dpc-4876	194	9	.	.	PUNCT
dpc-4876	195	1	therefore	therefore	ADV
dpc-4876	195	2	,	,	PUNCT
dpc-4876	195	3	atg7	atg7	PROPN
dpc-4876	195	4	-	-	PUNCT
dpc-4876	195	5	dependent	dependent	ADJ
dpc-4876	195	6	autophagy	autophagy	NOUN
dpc-4876	195	7	is	be	AUX
dpc-4876	195	8	important	important	ADJ
dpc-4876	195	9	for	for	ADP
dpc-4876	195	10	both	both	CCONJ
dpc-4876	195	11	melanocyte	melanocyte	NOUN
dpc-4876	195	12	function	function	NOUN
dpc-4876	195	13	and	and	CCONJ
dpc-4876	195	14	melanogenesis	melanogenesis	VERB
dpc-4876	195	15	[	[	X
dpc-4876	195	16	23	23	NUM
dpc-4876	195	17	]	]	PUNCT
dpc-4876	195	18	.	.	PUNCT
dpc-4876	196	1	moreover	moreover	ADV
dpc-4876	196	2	,	,	PUNCT
dpc-4876	196	3	suppression	suppression	NOUN
dpc-4876	196	4	of	of	ADP
dpc-4876	196	5	atg7	atg7	PROPN
dpc-4876	196	6	-	-	PUNCT
dpc-4876	196	7	dependent	dependent	ADJ
dpc-4876	196	8	autophagy	autophagy	NOUN
dpc-4876	196	9	in	in	ADP
dpc-4876	196	10	natural	natural	ADJ
dpc-4876	196	11	human	human	ADJ
dpc-4876	196	12	epidermal	epidermal	ADJ
dpc-4876	196	13	melanocytes	melanocyte	NOUN
dpc-4876	196	14	(	(	PUNCT
dpc-4876	196	15	nhem	nhem	NOUN
dpc-4876	196	16	)	)	PUNCT
dpc-4876	196	17	leads	lead	VERB
dpc-4876	196	18	to	to	ADP
dpc-4876	196	19	inhibition	inhibition	NOUN
dpc-4876	196	20	of	of	ADP
dpc-4876	196	21	melanocyte	melanocyte	NOUN
dpc-4876	196	22	proliferation	proliferation	NOUN
dpc-4876	196	23	,	,	PUNCT
dpc-4876	196	24	with	with	ADP
dpc-4876	196	25	an	an	DET
dpc-4876	196	26	increase	increase	NOUN
dpc-4876	196	27	in	in	ADP
dpc-4876	196	28	their	their	PRON
dpc-4876	196	29	oxidative	oxidative	ADJ
dpc-4876	196	30	stress	stress	NOUN
dpc-4876	196	31	-	-	PUNCT
dpc-4876	196	32	mediated	mediate	VERB
dpc-4876	196	33	apoptosis	apoptosis	NOUN
dpc-4876	196	34	,	,	PUNCT
dpc-4876	196	35	which	which	PRON
dpc-4876	196	36	leads	lead	VERB
dpc-4876	196	37	to	to	ADP
dpc-4876	196	38	premature	premature	ADJ
dpc-4876	196	39	melanocyte	melanocyte	NOUN
dpc-4876	196	40	senescence	senescence	NOUN
dpc-4876	196	41	.	.	PUNCT
dpc-4876	197	1	this	this	PRON
dpc-4876	197	2	reflects	reflect	VERB
dpc-4876	197	3	the	the	DET
dpc-4876	197	4	important	important	ADJ
dpc-4876	197	5	role	role	NOUN
dpc-4876	197	6	of	of	ADP
dpc-4876	197	7	atg7	atg7	PROPN
dpc-4876	197	8	in	in	ADP
dpc-4876	197	9	controlling	control	VERB
dpc-4876	197	10	oxidative	oxidative	ADJ
dpc-4876	197	11	stress	stress	NOUN
dpc-4876	197	12	homeostasis	homeostasis	NOUN
dpc-4876	197	13	and	and	CCONJ
dpc-4876	197	14	consequently	consequently	ADV
dpc-4876	197	15	melanocyte	melanocyte	NOUN
dpc-4876	197	16	functions	function	NOUN
dpc-4876	197	17	,	,	PUNCT
dpc-4876	197	18	including	include	VERB
dpc-4876	197	19	melanogenesis	melanogenesis	NOUN
dpc-4876	197	20	.	.	PUNCT
dpc-4876	198	1	also	also	ADV
dpc-4876	198	2	,	,	PUNCT
dpc-4876	198	3	this	this	DET
dpc-4876	198	4	atg7	atg7	PROPN
dpc-4876	198	5	suppression	suppression	NOUN
dpc-4876	198	6	has	have	AUX
dpc-4876	198	7	been	be	AUX
dpc-4876	198	8	associated	associate	VERB
dpc-4876	198	9	with	with	ADP
dpc-4876	198	10	a	a	DET
dpc-4876	198	11	decrease	decrease	NOUN
dpc-4876	198	12	in	in	ADP
dpc-4876	198	13	the	the	DET
dpc-4876	198	14	conversion	conversion	NOUN
dpc-4876	198	15	of	of	ADP
dpc-4876	198	16	lc3	lc3	NOUN
dpc-4876	198	17	-	-	NOUN
dpc-4876	198	18	i	i	PRON
dpc-4876	198	19	to	to	PART
dpc-4876	198	20	lc3	lc3	NOUN
dpc-4876	198	21	-	-	PUNCT
dpc-4876	198	22	ii	ii	NOUN
dpc-4876	198	23	,	,	PUNCT
dpc-4876	198	24	with	with	ADP
dpc-4876	198	25	an	an	DET
dpc-4876	198	26	increase	increase	NOUN
dpc-4876	198	27	in	in	ADP
dpc-4876	198	28	the	the	DET
dpc-4876	198	29	autophagy	autophagy	ADJ
dpc-4876	198	30	adapter	adapter	NOUN
dpc-4876	198	31	protein	protein	NOUN
dpc-4876	198	32	p62	p62	NOUN
dpc-4876	198	33	,	,	PUNCT
dpc-4876	198	34	reflecting	reflect	VERB
dpc-4876	198	35	the	the	DET
dpc-4876	198	36	stoppage	stoppage	NOUN
dpc-4876	198	37	of	of	ADP
dpc-4876	198	38	the	the	DET
dpc-4876	198	39	autophagic	autophagic	ADJ
dpc-4876	198	40	flux	flux	NOUN
dpc-4876	198	41	process	process	NOUN
dpc-4876	198	42	in	in	ADP
dpc-4876	198	43	nhem	nhem	PRON
dpc-4876	198	44	[	[	X
dpc-4876	198	45	24	24	NUM
dpc-4876	198	46	]	]	PUNCT
dpc-4876	198	47	.	.	PUNCT
dpc-4876	199	1	several	several	ADJ
dpc-4876	199	2	studies	study	NOUN
dpc-4876	199	3	[	[	X
dpc-4876	199	4	10	10	NUM
dpc-4876	199	5	,	,	PUNCT
dpc-4876	199	6	12	12	NUM
dpc-4876	199	7	,	,	PUNCT
dpc-4876	199	8	15	15	NUM
dpc-4876	199	9	,	,	PUNCT
dpc-4876	199	10	21	21	NUM
dpc-4876	199	11	-	-	SYM
dpc-4876	199	12	23	23	NUM
dpc-4876	199	13	]	]	PUNCT
dpc-4876	199	14	support	support	VERB
dpc-4876	199	15	the	the	DET
dpc-4876	199	16	important	important	ADJ
dpc-4876	199	17	role	role	NOUN
dpc-4876	199	18	of	of	ADP
dpc-4876	199	19	autophagy	autophagy	NOUN
dpc-4876	199	20	in	in	ADP
dpc-4876	199	21	melanogenesis	melanogenesis	NOUN
dpc-4876	199	22	in	in	ADP
dpc-4876	199	23	the	the	DET
dpc-4876	199	24	literature	literature	NOUN
dpc-4876	199	25	.	.	PUNCT
dpc-4876	200	1	melanosome	melanosome	NOUN
dpc-4876	200	2	trafficking	trafficking	NOUN
dpc-4876	200	3	is	be	AUX
dpc-4876	200	4	mediated	mediate	VERB
dpc-4876	200	5	by	by	ADP
dpc-4876	200	6	the	the	DET
dpc-4876	200	7	autophagic	autophagic	ADJ
dpc-4876	200	8	proteins	protein	NOUN
dpc-4876	200	9	lc3b	lc3b	PROPN
dpc-4876	200	10	and	and	CCONJ
dpc-4876	200	11	atg4b	atg4b	PROPN
dpc-4876	200	12	.	.	PUNCT
dpc-4876	201	1	this	this	DET
dpc-4876	201	2	8	8	NUM
dpc-4876	201	3	original	original	ADJ
dpc-4876	201	4	article	article	NOUN
dpc-4876	201	5	|	|	ADV
dpc-4876	201	6	dermatol	dermatol	ADJ
dpc-4876	201	7	pract	pract	NOUN
dpc-4876	201	8	concept	concept	NOUN
dpc-4876	201	9	.	.	PUNCT
dpc-4876	202	1	2025;15(2):4876	2025;15(2):4876	NOUN
dpc-4876	202	2	15	15	NUM
dpc-4876	202	3	.	.	PUNCT
dpc-4876	203	1	murase	murase	NOUN
dpc-4876	203	2	d	d	PROPN
dpc-4876	203	3	,	,	PUNCT
dpc-4876	203	4	hachiya	hachiya	PROPN
dpc-4876	203	5	a	a	PROPN
dpc-4876	203	6	,	,	PUNCT
dpc-4876	203	7	takano	takano	PROPN
dpc-4876	203	8	k	k	PROPN
dpc-4876	203	9	,	,	PUNCT
dpc-4876	203	10	et	et	PROPN
dpc-4876	203	11	al	al	PROPN
dpc-4876	203	12	.	.	PROPN
dpc-4876	203	13	autophagy	autophagy	PROPN
dpc-4876	203	14	has	have	VERB
dpc-4876	203	15	a	a	DET
dpc-4876	203	16	significant	significant	ADJ
dpc-4876	203	17	role	role	NOUN
dpc-4876	203	18	in	in	ADP
dpc-4876	203	19	determining	determine	VERB
dpc-4876	203	20	skin	skin	NOUN
dpc-4876	203	21	color	color	NOUN
dpc-4876	203	22	by	by	ADP
dpc-4876	203	23	regulating	regulate	VERB
dpc-4876	203	24	melanosome	melanosome	NOUN
dpc-4876	203	25	degradation	degradation	NOUN
dpc-4876	203	26	in	in	ADP
dpc-4876	203	27	keratinocytes	keratinocyte	NOUN
dpc-4876	203	28	.	.	PUNCT
dpc-4876	204	1	j.	j.	PROPN
dpc-4876	204	2	invest	invest	PROPN
dpc-4876	204	3	.	.	PUNCT
dpc-4876	205	1	dermatol	dermatol	NOUN
dpc-4876	205	2	.	.	PUNCT
dpc-4876	206	1	2013	2013	NUM
dpc-4876	206	2	;	;	PUNCT
dpc-4876	206	3	(	(	PUNCT
dpc-4876	206	4	133	133	NUM
dpc-4876	206	5	):	):	SYM
dpc-4876	206	6	2416	2416	NUM
dpc-4876	206	7	-	-	SYM
dpc-4876	206	8	2424	2424	NUM
dpc-4876	206	9	.	.	PUNCT
dpc-4876	207	1	doi:10.1038	doi:10.1038	NOUN
dpc-4876	207	2	/	/	SYM
dpc-4876	207	3	jid.2013.165	jid.2013.165	NOUN
dpc-4876	207	4	.	.	PUNCT
dpc-4876	208	1	16	16	NUM
dpc-4876	208	2	.	.	PUNCT
dpc-4876	208	3	nath	nath	PROPN
dpc-4876	208	4	b	b	PROPN
dpc-4876	208	5	,	,	PUNCT
dpc-4876	208	6	gupta	gupta	PROPN
dpc-4876	208	7	v	v	PROPN
dpc-4876	208	8	,	,	PUNCT
dpc-4876	208	9	kumari	kumari	PROPN
dpc-4876	208	10	r.	r.	PROPN
dpc-4876	208	11	a	a	DET
dpc-4876	208	12	community	community	NOUN
dpc-4876	208	13	based	base	VERB
dpc-4876	208	14	study	study	NOUN
dpc-4876	208	15	to	to	PART
dpc-4876	208	16	estimate	estimate	VERB
dpc-4876	208	17	prevalence	prevalence	NOUN
dpc-4876	208	18	and	and	CCONJ
dpc-4876	208	19	determine	determine	VERB
dpc-4876	208	20	correlates	correlate	NOUN
dpc-4876	208	21	of	of	ADP
dpc-4876	208	22	premature	premature	ADJ
dpc-4876	208	23	graying	graying	NOUN
dpc-4876	208	24	of	of	ADP
dpc-4876	208	25	hair	hair	NOUN
dpc-4876	208	26	among	among	ADP
dpc-4876	208	27	young	young	ADJ
dpc-4876	208	28	adults	adult	NOUN
dpc-4876	208	29	in	in	ADP
dpc-4876	208	30	srinagar	srinagar	PROPN
dpc-4876	208	31	,	,	PUNCT
dpc-4876	208	32	uttarakhand	uttarakhand	PROPN
dpc-4876	208	33	,	,	PUNCT
dpc-4876	208	34	india	india	PROPN
dpc-4876	208	35	.	.	PUNCT
dpc-4876	209	1	int	int	PROPN
dpc-4876	209	2	j	j	PROPN
dpc-4876	209	3	trichology	trichology	PROPN
dpc-4876	209	4	.	.	PUNCT
dpc-4876	210	1	2020	2020	NUM
dpc-4876	210	2	;	;	PUNCT
dpc-4876	210	3	(	(	PUNCT
dpc-4876	210	4	12):206	12):206	NUM
dpc-4876	210	5	-	-	SYM
dpc-4876	210	6	212	212	NUM
dpc-4876	210	7	.	.	PUNCT
dpc-4876	211	1	doi:10.4103	doi:10.4103	ADJ
dpc-4876	211	2	/	/	SYM
dpc-4876	211	3	ijt.ijt_28_19	ijt.ijt_28_19	PROPN
dpc-4876	211	4	.	.	PUNCT
dpc-4876	212	1	17	17	NUM
dpc-4876	212	2	.	.	PUNCT
dpc-4876	213	1	acer	acer	PROPN
dpc-4876	213	2	e	e	PROPN
dpc-4876	213	3	,	,	PUNCT
dpc-4876	213	4	arslantaş	arslantaş	PROPN
dpc-4876	213	5	d	d	NOUN
dpc-4876	213	6	,	,	PUNCT
dpc-4876	213	7	emiral	emiral	ADJ
dpc-4876	213	8	g	g	NOUN
dpc-4876	213	9	,	,	PUNCT
dpc-4876	213	10	ünsal	ünsal	PROPN
dpc-4876	213	11	a	a	PRON
dpc-4876	213	12	,	,	PUNCT
dpc-4876	213	13	atalay	atalay	ADJ
dpc-4876	213	14	bi	bi	NOUN
dpc-4876	213	15	,	,	PUNCT
dpc-4876	213	16	göktaş	göktaş	VERB
dpc-4876	213	17	s.	s.	PROPN
dpc-4876	213	18	clinical	clinical	ADJ
dpc-4876	213	19	and	and	CCONJ
dpc-4876	213	20	epidemiological	epidemiological	ADJ
dpc-4876	213	21	characteristics	characteristic	NOUN
dpc-4876	213	22	and	and	CCONJ
dpc-4876	213	23	associated	associated	ADJ
dpc-4876	213	24	factors	factor	NOUN
dpc-4876	213	25	of	of	ADP
dpc-4876	213	26	hair	hair	NOUN
dpc-4876	213	27	graying	gray	VERB
dpc-4876	213	28	:	:	PUNCT
dpc-4876	213	29	a	a	DET
dpc-4876	213	30	population	population	NOUN
dpc-4876	213	31	-	-	PUNCT
dpc-4876	213	32	based	base	VERB
dpc-4876	213	33	,	,	PUNCT
dpc-4876	213	34	cross	cross	ADJ
dpc-4876	213	35	-	-	ADJ
dpc-4876	213	36	sectional	sectional	ADJ
dpc-4876	213	37	study	study	NOUN
dpc-4876	213	38	in	in	ADP
dpc-4876	213	39	turkey	turkey	PROPN
dpc-4876	213	40	.	.	PUNCT
dpc-4876	214	1	an	an	DET
dpc-4876	214	2	bras	bras	NOUN
dpc-4876	214	3	dermatol	dermatol	NOUN
dpc-4876	214	4	.	.	PUNCT
dpc-4876	215	1	2020	2020	NUM
dpc-4876	215	2	;	;	PUNCT
dpc-4876	215	3	(	(	PUNCT
dpc-4876	215	4	95):439	95):439	NUM
dpc-4876	215	5	-	-	PUNCT
dpc-4876	215	6	446	446	NUM
dpc-4876	215	7	.	.	PUNCT
dpc-4876	216	1	doi:10.1016	doi:10.1016	PROPN
dpc-4876	216	2	/j.abd.2020.03.002	/j.abd.2020.03.002	PUNCT
dpc-4876	217	1	.	.	PROPN
dpc-4876	218	1	18	18	NUM
dpc-4876	218	2	.	.	X
dpc-4876	219	1	tanida	tanida	PROPN
dpc-4876	219	2	i	i	PROPN
dpc-4876	219	3	,	,	PUNCT
dpc-4876	219	4	ueno	ueno	PROPN
dpc-4876	219	5	t	t	PROPN
dpc-4876	219	6	,	,	PUNCT
dpc-4876	219	7	kominami	kominami	PROPN
dpc-4876	219	8	e.	e.	PROPN
dpc-4876	219	9	lc3	lc3	PROPN
dpc-4876	219	10	and	and	CCONJ
dpc-4876	219	11	autophagy	autophagy	VERB
dpc-4876	219	12	.	.	PUNCT
dpc-4876	220	1	methods	method	NOUN
dpc-4876	220	2	mol	mol	ADP
dpc-4876	220	3	biol	biol	PROPN
dpc-4876	220	4	.	.	PUNCT
dpc-4876	221	1	2008	2008	NUM
dpc-4876	221	2	;	;	PUNCT
dpc-4876	221	3	(	(	PUNCT
dpc-4876	221	4	445):77	445):77	NOUN
dpc-4876	221	5	-	-	SYM
dpc-4876	221	6	88	88	NUM
dpc-4876	221	7	.	.	PUNCT
dpc-4876	222	1	doi:10.1007/978	doi:10.1007/978	ADJ
dpc-4876	222	2	-	-	PUNCT
dpc-4876	222	3	1	1	NUM
dpc-4876	222	4	-	-	PUNCT
dpc-4876	222	5	59745	59745	NUM
dpc-4876	222	6	-	-	PUNCT
dpc-4876	222	7	157	157	NUM
dpc-4876	222	8	-	-	PUNCT
dpc-4876	222	9	4_4	4_4	NUM
dpc-4876	222	10	.	.	PUNCT
dpc-4876	223	1	19	19	NUM
dpc-4876	223	2	.	.	PUNCT
dpc-4876	223	3	edfors	edfor	NOUN
dpc-4876	223	4	f	f	X
dpc-4876	223	5	,	,	PUNCT
dpc-4876	223	6	danielsson	danielsson	PROPN
dpc-4876	223	7	f	f	PROPN
dpc-4876	223	8	,	,	PUNCT
dpc-4876	223	9	hallström	hallström	PROPN
dpc-4876	223	10	bm	bm	PROPN
dpc-4876	223	11	,	,	PUNCT
dpc-4876	223	12	et	et	PROPN
dpc-4876	223	13	al	al	PROPN
dpc-4876	223	14	.	.	PUNCT
dpc-4876	223	15	gene	gene	NOUN
dpc-4876	223	16	-	-	PUNCT
dpc-4876	223	17	specific	specific	ADJ
dpc-4876	223	18	correlation	correlation	NOUN
dpc-4876	223	19	of	of	ADP
dpc-4876	223	20	rna	rna	NOUN
dpc-4876	223	21	and	and	CCONJ
dpc-4876	223	22	protein	protein	NOUN
dpc-4876	223	23	levels	level	NOUN
dpc-4876	223	24	in	in	ADP
dpc-4876	223	25	human	human	ADJ
dpc-4876	223	26	cells	cell	NOUN
dpc-4876	223	27	and	and	CCONJ
dpc-4876	223	28	tissues	tissue	NOUN
dpc-4876	223	29	.	.	PUNCT
dpc-4876	224	1	mol	mol	ADP
dpc-4876	224	2	syst	syst	PROPN
dpc-4876	224	3	biol	biol	PROPN
dpc-4876	224	4	.	.	PUNCT
dpc-4876	225	1	2016	2016	NUM
dpc-4876	225	2	;	;	PUNCT
dpc-4876	225	3	(	(	PUNCT
dpc-4876	225	4	12):883	12):883	NOUN
dpc-4876	225	5	.	.	PUNCT
dpc-4876	225	6	doi:10.15252	doi:10.15252	NOUN
dpc-4876	225	7	/	/	SYM
dpc-4876	226	1	msb.20167144	msb.20167144	PROPN
dpc-4876	226	2	.	.	NOUN
dpc-4876	226	3	20	20	NUM
dpc-4876	226	4	.	.	X
dpc-4876	226	5	fortelny	fortelny	PROPN
dpc-4876	226	6	n	n	CCONJ
dpc-4876	226	7	,	,	PUNCT
dpc-4876	226	8	overall	overall	ADJ
dpc-4876	226	9	cm	cm	NOUN
dpc-4876	226	10	,	,	PUNCT
dpc-4876	226	11	pavlidis	pavlidi	NOUN
dpc-4876	226	12	p	p	X
dpc-4876	226	13	,	,	PUNCT
dpc-4876	226	14	freue	freue	PROPN
dpc-4876	226	15	gvc	gvc	PROPN
dpc-4876	226	16	.	.	PUNCT
dpc-4876	227	1	can	can	AUX
dpc-4876	227	2	we	we	PRON
dpc-4876	227	3	predict	predict	VERB
dpc-4876	227	4	protein	protein	NOUN
dpc-4876	227	5	from	from	ADP
dpc-4876	227	6	mrna	mrna	PROPN
dpc-4876	227	7	levels	level	NOUN
dpc-4876	227	8	?	?	PUNCT
dpc-4876	228	1	nature	nature	NOUN
dpc-4876	228	2	.	.	PUNCT
dpc-4876	229	1	2017	2017	NUM
dpc-4876	229	2	;	;	PUNCT
dpc-4876	229	3	(	(	PUNCT
dpc-4876	229	4	547):e19	547):e19	NUM
dpc-4876	229	5	-	-	PUNCT
dpc-4876	229	6	e20	e20	NOUN
dpc-4876	229	7	.	.	PUNCT
dpc-4876	230	1	doi:10.1038	doi:10.1038	PROPN
dpc-4876	230	2	/	/	SYM
dpc-4876	230	3	nature22293	nature22293	PROPN
dpc-4876	230	4	.	.	PUNCT
dpc-4876	231	1	21	21	NUM
dpc-4876	231	2	.	.	PUNCT
dpc-4876	232	1	yang	yang	PROPN
dpc-4876	232	2	f	f	PROPN
dpc-4876	232	3	,	,	PUNCT
dpc-4876	232	4	yang	yang	PROPN
dpc-4876	232	5	l	l	PROPN
dpc-4876	232	6	,	,	PUNCT
dpc-4876	232	7	wataya	wataya	PROPN
dpc-4876	232	8	-	-	PUNCT
dpc-4876	232	9	kaneda	kaneda	PROPN
dpc-4876	232	10	m	m	PROPN
dpc-4876	232	11	,	,	PUNCT
dpc-4876	232	12	et	et	PROPN
dpc-4876	232	13	al	al	PROPN
dpc-4876	232	14	.	.	PROPN
dpc-4876	232	15	dysregulation	dysregulation	NOUN
dpc-4876	232	16	of	of	ADP
dpc-4876	232	17	autophagy	autophagy	NOUN
dpc-4876	232	18	in	in	ADP
dpc-4876	232	19	melanocytes	melanocyte	NOUN
dpc-4876	232	20	contributes	contribute	VERB
dpc-4876	232	21	to	to	ADP
dpc-4876	232	22	hypopigmented	hypopigmente	VERB
dpc-4876	232	23	macules	macule	NOUN
dpc-4876	232	24	in	in	ADP
dpc-4876	232	25	tuberous	tuberous	ADJ
dpc-4876	232	26	sclerosis	sclerosis	NOUN
dpc-4876	232	27	complex	complex	NOUN
dpc-4876	232	28	.	.	PUNCT
dpc-4876	233	1	j	j	PROPN
dpc-4876	233	2	dermatol	dermatol	NOUN
dpc-4876	233	3	sci	sci	PROPN
dpc-4876	233	4	.	.	PROPN
dpc-4876	233	5	2018	2018	NUM
dpc-4876	233	6	;	;	PUNCT
dpc-4876	233	7	(	(	PUNCT
dpc-4876	233	8	89):155	89):155	NUM
dpc-4876	233	9	-	-	NOUN
dpc-4876	233	10	164	164	NUM
dpc-4876	233	11	.	.	PUNCT
dpc-4876	233	12	doi:10.1016	doi:10.1016	PROPN
dpc-4876	233	13	/	/	SYM
dpc-4876	233	14	j.jdermsci.2017.11.002	j.jdermsci.2017.11.002	PROPN
dpc-4876	233	15	.	.	PROPN
dpc-4876	233	16	22	22	NUM
dpc-4876	233	17	.	.	PUNCT
dpc-4876	234	1	kim	kim	PROPN
dpc-4876	234	2	jy	jy	PROPN
dpc-4876	234	3	,	,	PUNCT
dpc-4876	234	4	kim	kim	PROPN
dpc-4876	234	5	j	j	PROPN
dpc-4876	234	6	,	,	PUNCT
dpc-4876	234	7	ahn	ahn	PROPN
dpc-4876	234	8	y	y	PROPN
dpc-4876	234	9	,	,	PUNCT
dpc-4876	234	10	et	et	PROPN
dpc-4876	234	11	al	al	PROPN
dpc-4876	234	12	.	.	PUNCT
dpc-4876	235	1	autophagy	autophagy	ADJ
dpc-4876	235	2	induction	induction	NOUN
dpc-4876	235	3	can	can	AUX
dpc-4876	235	4	regulate	regulate	VERB
dpc-4876	235	5	skin	skin	NOUN
dpc-4876	235	6	pigmentation	pigmentation	NOUN
dpc-4876	235	7	by	by	ADP
dpc-4876	235	8	causing	cause	VERB
dpc-4876	235	9	melanosome	melanosome	NOUN
dpc-4876	235	10	degradation	degradation	NOUN
dpc-4876	235	11	in	in	ADP
dpc-4876	235	12	keratinocytes	keratinocyte	NOUN
dpc-4876	235	13	and	and	CCONJ
dpc-4876	235	14	melanocytes	melanocyte	NOUN
dpc-4876	235	15	.	.	PUNCT
dpc-4876	236	1	pigment	pigment	ADJ
dpc-4876	236	2	cell	cell	NOUN
dpc-4876	236	3	melanoma	melanoma	NOUN
dpc-4876	236	4	res	re	NOUN
dpc-4876	236	5	.	.	PUNCT
dpc-4876	237	1	2020	2020	NUM
dpc-4876	237	2	;	;	PUNCT
dpc-4876	237	3	(	(	PUNCT
dpc-4876	237	4	33):403	33):403	NUM
dpc-4876	237	5	-	-	SYM
dpc-4876	237	6	415	415	NUM
dpc-4876	237	7	.	.	PUNCT
dpc-4876	238	1	doi:10.1111	doi:10.1111	PROPN
dpc-4876	238	2	/	/	SYM
dpc-4876	238	3	pcmr.12838	pcmr.12838	PROPN
dpc-4876	238	4	.	.	PROPN
dpc-4876	238	5	23	23	NUM
dpc-4876	238	6	.	.	PUNCT
dpc-4876	239	1	zhang	zhang	PROPN
dpc-4876	239	2	c	c	X
dpc-4876	239	3	-	-	PUNCT
dpc-4876	239	4	f	f	PROPN
dpc-4876	239	5	,	,	PUNCT
dpc-4876	239	6	gruber	gruber	PROPN
dpc-4876	239	7	f	f	PROPN
dpc-4876	239	8	,	,	PUNCT
dpc-4876	239	9	ni	ni	PROPN
dpc-4876	239	10	c	c	PROPN
dpc-4876	239	11	,	,	PUNCT
dpc-4876	239	12	et	et	PROPN
dpc-4876	239	13	al	al	PROPN
dpc-4876	239	14	.	.	PROPN
dpc-4876	239	15	suppression	suppression	NOUN
dpc-4876	239	16	of	of	ADP
dpc-4876	239	17	autophagy	autophagy	ADJ
dpc-4876	239	18	dysregulates	dysregulate	NOUN
dpc-4876	239	19	the	the	DET
dpc-4876	239	20	antioxidant	antioxidant	ADJ
dpc-4876	239	21	response	response	NOUN
dpc-4876	239	22	and	and	CCONJ
dpc-4876	239	23	causes	cause	VERB
dpc-4876	239	24	premature	premature	ADJ
dpc-4876	239	25	senescence	senescence	NOUN
dpc-4876	239	26	of	of	ADP
dpc-4876	239	27	melanocytes	melanocyte	NOUN
dpc-4876	239	28	.	.	PUNCT
dpc-4876	240	1	j.	j.	PROPN
dpc-4876	240	2	invest	invest	PROPN
dpc-4876	240	3	.	.	PUNCT
dpc-4876	241	1	dermatol	dermatol	NOUN
dpc-4876	241	2	.	.	PUNCT
dpc-4876	242	1	2015	2015	NUM
dpc-4876	242	2	;	;	PUNCT
dpc-4876	242	3	(	(	PUNCT
dpc-4876	242	4	135	135	NUM
dpc-4876	242	5	):	):	PUNCT
dpc-4876	242	6	1348	1348	NUM
dpc-4876	242	7	-	-	SYM
dpc-4876	242	8	1357	1357	NUM
dpc-4876	242	9	.	.	PUNCT
dpc-4876	243	1	doi:10.1038	doi:10.1038	NOUN
dpc-4876	243	2	/	/	SYM
dpc-4876	243	3	jid.2014.439	jid.2014.439	PROPN
dpc-4876	243	4	.	.	PUNCT
dpc-4876	244	1	24	24	NUM
dpc-4876	244	2	.	.	PUNCT
dpc-4876	245	1	qiao	qiao	PROPN
dpc-4876	245	2	z	z	PROPN
dpc-4876	245	3	,	,	PUNCT
dpc-4876	245	4	xu	xu	PROPN
dpc-4876	246	1	z	z	PROPN
dpc-4876	246	2	,	,	PUNCT
dpc-4876	246	3	xiao	xiao	PROPN
dpc-4876	246	4	q	q	PROPN
dpc-4876	246	5	,	,	PUNCT
dpc-4876	246	6	et	et	PROPN
dpc-4876	246	7	al	al	PROPN
dpc-4876	246	8	.	.	PUNCT
dpc-4876	246	9	dysfunction	dysfunction	NOUN
dpc-4876	246	10	of	of	ADP
dpc-4876	246	11	atg7	atg7	PROPN
dpc-4876	246	12	-	-	PUNCT
dpc-4876	246	13	dependent	dependent	ADJ
dpc-4876	246	14	autophagy	autophagy	NOUN
dpc-4876	246	15	dysregulates	dysregulate	VERB
dpc-4876	246	16	the	the	DET
dpc-4876	246	17	antioxidant	antioxidant	ADJ
dpc-4876	246	18	response	response	NOUN
dpc-4876	246	19	and	and	CCONJ
dpc-4876	246	20	contributes	contribute	VERB
dpc-4876	246	21	to	to	PART
dpc-4876	246	22	oxidative	oxidative	ADJ
dpc-4876	246	23	stress	stress	NOUN
dpc-4876	246	24	-	-	PUNCT
dpc-4876	246	25	induced	induce	VERB
dpc-4876	246	26	biological	biological	ADJ
dpc-4876	246	27	impairments	impairment	NOUN
dpc-4876	246	28	in	in	ADP
dpc-4876	246	29	human	human	ADJ
dpc-4876	246	30	epidermal	epidermal	ADJ
dpc-4876	246	31	melanocytes	melanocyte	NOUN
dpc-4876	246	32	.	.	PUNCT
dpc-4876	247	1	cell	cell	NOUN
dpc-4876	247	2	death	death	NOUN
dpc-4876	247	3	discov	discov	NOUN
dpc-4876	247	4	.	.	PUNCT
dpc-4876	248	1	2020	2020	NUM
dpc-4876	248	2	;	;	PUNCT
dpc-4876	248	3	(	(	PUNCT
dpc-4876	248	4	6):31	6):31	NUM
dpc-4876	248	5	.	.	PUNCT
dpc-4876	248	6	doi:10.1038	doi:10.1038	NOUN
dpc-4876	248	7	/	/	SYM
dpc-4876	248	8	s41420	s41420	NOUN
dpc-4876	248	9	-	-	PUNCT
dpc-4876	248	10	020	020	NUM
dpc-4876	248	11	-	-	PUNCT
dpc-4876	248	12	0266	0266	NUM
dpc-4876	248	13	-	-	SYM
dpc-4876	248	14	3	3	NUM
dpc-4876	248	15	.	.	NOUN
dpc-4876	248	16	25	25	NUM
dpc-4876	248	17	.	.	PUNCT
dpc-4876	248	18	parodi	parodi	PROPN
dpc-4876	248	19	c	c	PROPN
dpc-4876	248	20	,	,	PUNCT
dpc-4876	248	21	hardman	hardman	PROPN
dpc-4876	248	22	ja	ja	PROPN
dpc-4876	248	23	,	,	PUNCT
dpc-4876	248	24	allavena	allavena	PROPN
dpc-4876	248	25	g	g	PROPN
dpc-4876	248	26	,	,	PUNCT
dpc-4876	248	27	et	et	PROPN
dpc-4876	248	28	al	al	PROPN
dpc-4876	248	29	.	.	PUNCT
dpc-4876	249	1	autophagy	autophagy	PROPN
dpc-4876	249	2	is	be	AUX
dpc-4876	249	3	essential	essential	ADJ
dpc-4876	249	4	for	for	ADP
dpc-4876	249	5	maintaining	maintain	VERB
dpc-4876	249	6	the	the	DET
dpc-4876	249	7	growth	growth	NOUN
dpc-4876	249	8	of	of	ADP
dpc-4876	249	9	a	a	DET
dpc-4876	249	10	human	human	NOUN
dpc-4876	249	11	(	(	PUNCT
dpc-4876	249	12	mini-)organ	mini-)organ	NOUN
dpc-4876	249	13	:	:	PUNCT
dpc-4876	249	14	evidence	evidence	NOUN
dpc-4876	249	15	from	from	ADP
dpc-4876	249	16	scalp	scalp	NOUN
dpc-4876	249	17	hair	hair	NOUN
dpc-4876	249	18	follicle	follicle	NOUN
dpc-4876	249	19	organ	organ	NOUN
dpc-4876	249	20	culture	culture	NOUN
dpc-4876	249	21	.	.	PUNCT
dpc-4876	250	1	plos	plos	PROPN
dpc-4876	250	2	biol	biol	PROPN
dpc-4876	250	3	.	.	PUNCT
dpc-4876	251	1	2018	2018	NUM
dpc-4876	251	2	;	;	PUNCT
dpc-4876	251	3	(	(	PUNCT
dpc-4876	251	4	16):e2002864	16):e2002864	NUM
dpc-4876	251	5	.	.	PUNCT
dpc-4876	251	6	doi:10.1371	doi:10.1371	PROPN
dpc-4876	251	7	/	/	SYM
dpc-4876	252	1	journal.pbio.2002864	journal.pbio.2002864	PROPN
dpc-4876	252	2	.	.	PROPN
dpc-4876	253	1	26	26	NUM
dpc-4876	253	2	.	.	PUNCT
dpc-4876	254	1	anggraini	anggraini	PROPN
dpc-4876	254	2	dr	dr	PROPN
dpc-4876	254	3	,	,	PUNCT
dpc-4876	254	4	feriyawati	feriyawati	NOUN
dpc-4876	254	5	l	l	NOUN
dpc-4876	254	6	,	,	PUNCT
dpc-4876	254	7	hidayat	hidayat	PROPN
dpc-4876	254	8	h	h	PROPN
dpc-4876	254	9	,	,	PUNCT
dpc-4876	254	10	wahyuni	wahyuni	PROPN
dpc-4876	254	11	as	as	ADP
dpc-4876	254	12	.	.	PUNCT
dpc-4876	255	1	risk	risk	NOUN
dpc-4876	255	2	factors	factor	NOUN
dpc-4876	255	3	associated	associate	VERB
dpc-4876	255	4	with	with	ADP
dpc-4876	255	5	premature	premature	ADJ
dpc-4876	255	6	hair	hair	NOUN
dpc-4876	255	7	greying	greying	NOUN
dpc-4876	255	8	of	of	ADP
dpc-4876	255	9	young	young	ADJ
dpc-4876	255	10	adult	adult	NOUN
dpc-4876	255	11	.	.	PUNCT
dpc-4876	256	1	open	open	ADJ
dpc-4876	256	2	access	access	NOUN
dpc-4876	256	3	maced	mace	VERB
dpc-4876	256	4	j	j	PROPN
dpc-4876	256	5	med	med	PROPN
dpc-4876	256	6	sci	sci	PROPN
dpc-4876	256	7	.	.	PROPN
dpc-4876	256	8	2019	2019	NUM
dpc-4876	256	9	;	;	PUNCT
dpc-4876	256	10	(	(	PUNCT
dpc-4876	256	11	7):3762	7):3762	NOUN
dpc-4876	256	12	-	-	PUNCT
dpc-4876	256	13	3764	3764	NUM
dpc-4876	256	14	.	.	PUNCT
dpc-4876	257	1	doi:10.3889	doi:10.3889	PROPN
dpc-4876	257	2	/	/	SYM
dpc-4876	257	3	oamjms.2019.498	oamjms.2019.498	PROPN
dpc-4876	257	4	.	.	PROPN
dpc-4876	258	1	27	27	NUM
dpc-4876	258	2	.	.	PUNCT
dpc-4876	259	1	mahendiratta	mahendiratta	PROPN
dpc-4876	259	2	s	s	PART
dpc-4876	259	3	,	,	PUNCT
dpc-4876	259	4	sarma	sarma	PROPN
dpc-4876	259	5	p	p	PROPN
dpc-4876	259	6	,	,	PUNCT
dpc-4876	259	7	kaur	kaur	PROPN
dpc-4876	259	8	h	h	PROPN
dpc-4876	259	9	,	,	PUNCT
dpc-4876	259	10	et	et	PROPN
dpc-4876	259	11	al	al	PROPN
dpc-4876	259	12	.	.	PUNCT
dpc-4876	260	1	premature	premature	ADJ
dpc-4876	260	2	graying	graying	NOUN
dpc-4876	260	3	of	of	ADP
dpc-4876	260	4	hair	hair	NOUN
dpc-4876	260	5	:	:	PUNCT
dpc-4876	260	6	risk	risk	NOUN
dpc-4876	260	7	factors	factor	NOUN
dpc-4876	260	8	,	,	PUNCT
dpc-4876	260	9	co	co	ADJ
dpc-4876	260	10	-	-	ADJ
dpc-4876	260	11	morbid	morbid	ADJ
dpc-4876	260	12	conditions	condition	NOUN
dpc-4876	260	13	,	,	PUNCT
dpc-4876	260	14	pharmacotherapy	pharmacotherapy	NOUN
dpc-4876	260	15	and	and	CCONJ
dpc-4876	260	16	reversal	reversal	NOUN
dpc-4876	260	17	—	—	PUNCT
dpc-4876	260	18	a	a	DET
dpc-4876	260	19	systematic	systematic	ADJ
dpc-4876	260	20	review	review	NOUN
dpc-4876	260	21	and	and	CCONJ
dpc-4876	260	22	meta	meta	ADJ
dpc-4876	260	23	-	-	PUNCT
dpc-4876	260	24	analysis	analysis	NOUN
dpc-4876	260	25	.	.	PUNCT
dpc-4876	261	1	dermatol	dermatol	NOUN
dpc-4876	261	2	.	.	PUNCT
dpc-4876	262	1	ther	ther	PROPN
dpc-4876	262	2	.	.	PUNCT
dpc-4876	263	1	2020	2020	NUM
dpc-4876	263	2	;	;	PUNCT
dpc-4876	263	3	(	(	PUNCT
dpc-4876	263	4	33):e13990	33):e13990	NOUN
dpc-4876	263	5	.	.	PUNCT
dpc-4876	264	1	doi:10.1111	doi:10.1111	PROPN
dpc-4876	264	2	/	/	SYM
dpc-4876	264	3	dth.13990	dth.13990	NOUN
dpc-4876	264	4	.	.	NOUN
dpc-4876	264	5	28	28	NUM
dpc-4876	264	6	.	.	PUNCT
dpc-4876	265	1	saxena	saxena	PROPN
dpc-4876	265	2	s	s	PROPN
dpc-4876	265	3	,	,	PUNCT
dpc-4876	265	4	gautam	gautam	PROPN
dpc-4876	265	5	rk	rk	PROPN
dpc-4876	265	6	,	,	PUNCT
dpc-4876	265	7	gupta	gupta	PROPN
dpc-4876	265	8	a	a	PRON
dpc-4876	265	9	,	,	PUNCT
dpc-4876	265	10	chitkara	chitkara	ADJ
dpc-4876	265	11	a.	a.	NOUN
dpc-4876	265	12	evaluation	evaluation	NOUN
dpc-4876	265	13	of	of	ADP
dpc-4876	265	14	systemic	systemic	ADJ
dpc-4876	265	15	oxidative	oxidative	ADJ
dpc-4876	265	16	stress	stress	NOUN
dpc-4876	265	17	in	in	ADP
dpc-4876	265	18	patients	patient	NOUN
dpc-4876	265	19	with	with	ADP
dpc-4876	265	20	premature	premature	ADJ
dpc-4876	265	21	canities	canitie	NOUN
dpc-4876	265	22	and	and	CCONJ
dpc-4876	265	23	correlation	correlation	NOUN
dpc-4876	265	24	of	of	ADP
dpc-4876	265	25	severity	severity	NOUN
dpc-4876	265	26	of	of	ADP
dpc-4876	265	27	hair	hair	NOUN
dpc-4876	265	28	graying	gray	VERB
dpc-4876	265	29	with	with	ADP
dpc-4876	265	30	the	the	DET
dpc-4876	265	31	degree	degree	NOUN
dpc-4876	265	32	of	of	ADP
dpc-4876	265	33	redox	redox	ADJ
dpc-4876	265	34	imbalance	imbalance	NOUN
dpc-4876	265	35	.	.	PUNCT
dpc-4876	266	1	int	int	NOUN
dpc-4876	266	2	j	j	PROPN
dpc-4876	266	3	trichology	trichology	PROPN
dpc-4876	266	4	.	.	PUNCT
dpc-4876	267	1	2020	2020	NUM
dpc-4876	267	2	;	;	PUNCT
dpc-4876	267	3	(	(	PUNCT
dpc-4876	267	4	12):16	12):16	NUM
dpc-4876	267	5	-	-	SYM
dpc-4876	267	6	23	23	NUM
dpc-4876	267	7	.	.	PUNCT
dpc-4876	268	1	doi:10.4103	doi:10.4103	PROPN
dpc-4876	268	2	/	/	SYM
dpc-4876	268	3	ijt.ijt_99_19	ijt.ijt_99_19	PROPN
dpc-4876	268	4	.	.	PROPN
dpc-4876	268	5	references	reference	NOUN
dpc-4876	268	6	1	1	NUM
dpc-4876	268	7	.	.	PUNCT
dpc-4876	268	8	maymone	maymone	PROPN
dpc-4876	268	9	mbc	mbc	PROPN
dpc-4876	268	10	,	,	PUNCT
dpc-4876	268	11	laughter	laughter	NOUN
dpc-4876	268	12	m	m	PROPN
dpc-4876	268	13	,	,	PUNCT
dpc-4876	268	14	pollock	pollock	NOUN
dpc-4876	268	15	s	s	PROPN
dpc-4876	268	16	,	,	PUNCT
dpc-4876	268	17	et	et	PROPN
dpc-4876	268	18	al	al	PROPN
dpc-4876	268	19	.	.	PROPN
dpc-4876	268	20	hair	hair	NOUN
dpc-4876	268	21	aging	age	VERB
dpc-4876	268	22	in	in	ADP
dpc-4876	268	23	different	different	ADJ
dpc-4876	268	24	races	race	NOUN
dpc-4876	268	25	and	and	CCONJ
dpc-4876	268	26	ethnicities	ethnicity	NOUN
dpc-4876	268	27	.	.	PUNCT
dpc-4876	269	1	j	j	PROPN
dpc-4876	269	2	clin	clin	PROPN
dpc-4876	269	3	aesthet	aesthet	PROPN
dpc-4876	269	4	dermatol	dermatol	PROPN
dpc-4876	269	5	.	.	PUNCT
dpc-4876	270	1	2021	2021	NUM
dpc-4876	270	2	;	;	PUNCT
dpc-4876	270	3	(	(	PUNCT
dpc-4876	270	4	14):38	14):38	NUM
dpc-4876	270	5	-	-	SYM
dpc-4876	270	6	44	44	NUM
dpc-4876	270	7	.	.	NOUN
dpc-4876	271	1	2	2	X
dpc-4876	271	2	.	.	X
dpc-4876	271	3	panhard	panhard	PROPN
dpc-4876	271	4	s	s	PROPN
dpc-4876	271	5	,	,	PUNCT
dpc-4876	271	6	lozano	lozano	PROPN
dpc-4876	271	7	i	i	PROPN
dpc-4876	271	8	,	,	PUNCT
dpc-4876	271	9	loussouarn	loussouarn	ADJ
dpc-4876	271	10	g.	g.	NOUN
dpc-4876	271	11	greying	greying	NOUN
dpc-4876	271	12	of	of	ADP
dpc-4876	271	13	the	the	DET
dpc-4876	271	14	human	human	ADJ
dpc-4876	271	15	hair	hair	NOUN
dpc-4876	271	16	:	:	PUNCT
dpc-4876	271	17	a	a	DET
dpc-4876	271	18	worldwide	worldwide	ADJ
dpc-4876	271	19	survey	survey	NOUN
dpc-4876	271	20	,	,	PUNCT
dpc-4876	271	21	revisiting	revisit	VERB
dpc-4876	271	22	the	the	DET
dpc-4876	271	23	‘	'	PUNCT
dpc-4876	271	24	50	50	NUM
dpc-4876	271	25	’	'	PUNCT
dpc-4876	271	26	rule	rule	NOUN
dpc-4876	271	27	of	of	ADP
dpc-4876	271	28	thumb	thumb	NOUN
dpc-4876	271	29	.	.	PUNCT
dpc-4876	272	1	br	br	X
dpc-4876	272	2	.	.	PUNCT
dpc-4876	273	1	j.	j.	PROPN
dpc-4876	273	2	dermatol	dermatol	PROPN
dpc-4876	273	3	.	.	PUNCT
dpc-4876	274	1	2012	2012	NUM
dpc-4876	274	2	;	;	PUNCT
dpc-4876	274	3	(	(	PUNCT
dpc-4876	274	4	167):865	167):865	NUM
dpc-4876	274	5	-	-	SYM
dpc-4876	274	6	873	873	NUM
dpc-4876	274	7	.	.	PUNCT
dpc-4876	275	1	doi:10.1111	doi:10.1111	ADJ
dpc-4876	275	2	/	/	SYM
dpc-4876	275	3	j.1365	j.1365	NOUN
dpc-4876	275	4	-	-	PUNCT
dpc-4876	275	5	2133.2012	2133.2012	NUM
dpc-4876	275	6	.11095.x	.11095.x	NOUN
dpc-4876	275	7	.	.	PUNCT
dpc-4876	276	1	3	3	X
dpc-4876	276	2	.	.	X
dpc-4876	276	3	pandhi	pandhi	PROPN
dpc-4876	276	4	d	d	PROPN
dpc-4876	276	5	,	,	PUNCT
dpc-4876	276	6	khanna	khanna	PROPN
dpc-4876	276	7	d.	d.	PROPN
dpc-4876	276	8	premature	premature	PROPN
dpc-4876	276	9	graying	gray	VERB
dpc-4876	276	10	of	of	ADP
dpc-4876	276	11	hair	hair	NOUN
dpc-4876	276	12	.	.	PUNCT
dpc-4876	277	1	indian	indian	ADJ
dpc-4876	277	2	j.	j.	PROPN
dpc-4876	277	3	dermatol	dermatol	PROPN
dpc-4876	277	4	.	.	PUNCT
dpc-4876	278	1	venereol	venereol	PROPN
dpc-4876	278	2	.	.	PUNCT
dpc-4876	279	1	leprol	leprol	PROPN
dpc-4876	279	2	.	.	PUNCT
dpc-4876	280	1	2013	2013	NUM
dpc-4876	280	2	;	;	PUNCT
dpc-4876	280	3	(	(	PUNCT
dpc-4876	280	4	79):641	79):641	NUM
dpc-4876	280	5	-	-	PUNCT
dpc-4876	280	6	653	653	NUM
dpc-4876	280	7	.	.	PUNCT
dpc-4876	280	8	doi:10.4103/0378	doi:10.4103/0378	VERB
dpc-4876	280	9	-6323.116733	-6323.116733	X
dpc-4876	280	10	.	.	PROPN
dpc-4876	281	1	4	4	X
dpc-4876	281	2	.	.	X
dpc-4876	281	3	bhat	bhat	PROPN
dpc-4876	281	4	rm	rm	PROPN
dpc-4876	281	5	,	,	PUNCT
dpc-4876	281	6	sharma	sharma	PROPN
dpc-4876	281	7	r	r	PROPN
dpc-4876	281	8	,	,	PUNCT
dpc-4876	281	9	pinto	pinto	NOUN
dpc-4876	281	10	ac	ac	PROPN
dpc-4876	281	11	,	,	PUNCT
dpc-4876	281	12	dandekeri	dandekeri	NOUN
dpc-4876	281	13	s	s	NOUN
dpc-4876	281	14	,	,	PUNCT
dpc-4876	281	15	martis	martis	NOUN
dpc-4876	281	16	j.	j.	PROPN
dpc-4876	281	17	epidemiological	epidemiological	ADJ
dpc-4876	281	18	and	and	CCONJ
dpc-4876	281	19	investigative	investigative	ADJ
dpc-4876	281	20	study	study	NOUN
dpc-4876	281	21	of	of	ADP
dpc-4876	281	22	premature	premature	ADJ
dpc-4876	281	23	graying	graying	NOUN
dpc-4876	281	24	of	of	ADP
dpc-4876	281	25	hair	hair	NOUN
dpc-4876	281	26	in	in	ADP
dpc-4876	281	27	higher	high	ADJ
dpc-4876	281	28	secondary	secondary	ADJ
dpc-4876	281	29	and	and	CCONJ
dpc-4876	281	30	pre	pre	ADJ
dpc-4876	281	31	-	-	ADJ
dpc-4876	281	32	university	university	ADJ
dpc-4876	281	33	school	school	NOUN
dpc-4876	281	34	children	child	NOUN
dpc-4876	281	35	.	.	PUNCT
dpc-4876	282	1	int	int	NOUN
dpc-4876	282	2	j	j	PROPN
dpc-4876	282	3	trichology	trichology	PROPN
dpc-4876	282	4	.	.	PUNCT
dpc-4876	283	1	2013	2013	NUM
dpc-4876	283	2	;	;	PUNCT
dpc-4876	283	3	(	(	PUNCT
dpc-4876	283	4	5):17	5):17	NUM
dpc-4876	283	5	-	-	SYM
dpc-4876	283	6	21	21	NUM
dpc-4876	283	7	.	.	PUNCT
dpc-4876	284	1	doi:10.4103/0974	doi:10.4103/0974	PROPN
dpc-4876	284	2	-	-	PUNCT
dpc-4876	284	3	7753.114706	7753.114706	NUM
dpc-4876	284	4	.	.	PUNCT
dpc-4876	285	1	5	5	NUM
dpc-4876	285	2	.	.	X
dpc-4876	285	3	tobin	tobin	PROPN
dpc-4876	285	4	dj	dj	PROPN
dpc-4876	285	5	,	,	PUNCT
dpc-4876	285	6	paus	paus	PROPN
dpc-4876	285	7	r.	r.	PROPN
dpc-4876	285	8	graying	graying	PROPN
dpc-4876	285	9	:	:	PUNCT
dpc-4876	285	10	gerontobiology	gerontobiology	NOUN
dpc-4876	285	11	of	of	ADP
dpc-4876	285	12	the	the	DET
dpc-4876	285	13	hair	hair	NOUN
dpc-4876	285	14	follicle	follicle	NOUN
dpc-4876	285	15	pigmentary	pigmentary	NOUN
dpc-4876	285	16	unit	unit	NOUN
dpc-4876	285	17	.	.	PUNCT
dpc-4876	286	1	exp	exp	NOUN
dpc-4876	286	2	.	.	PROPN
dpc-4876	286	3	gerontol	gerontol	PROPN
dpc-4876	286	4	.	.	PUNCT
dpc-4876	287	1	2001	2001	NUM
dpc-4876	287	2	;	;	PUNCT
dpc-4876	287	3	(	(	PUNCT
dpc-4876	287	4	36):29	36):29	NUM
dpc-4876	287	5	-	-	SYM
dpc-4876	287	6	54	54	NUM
dpc-4876	287	7	.	.	PUNCT
dpc-4876	288	1	doi:10.1016	doi:10.1016	PROPN
dpc-4876	289	1	/s0531	/s0531	PROPN
dpc-4876	289	2	-	-	PUNCT
dpc-4876	289	3	5565(00)00210	5565(00)00210	NUM
dpc-4876	289	4	-	-	SYM
dpc-4876	289	5	2	2	NUM
dpc-4876	289	6	.	.	NOUN
dpc-4876	289	7	6	6	NUM
dpc-4876	289	8	.	.	PUNCT
dpc-4876	290	1	sharma	sharma	PROPN
dpc-4876	290	2	n	n	CCONJ
dpc-4876	290	3	,	,	PUNCT
dpc-4876	290	4	dogra	dogra	PROPN
dpc-4876	290	5	d.	d.	PROPN
dpc-4876	290	6	association	association	PROPN
dpc-4876	290	7	of	of	ADP
dpc-4876	290	8	epidemiological	epidemiological	ADJ
dpc-4876	290	9	and	and	CCONJ
dpc-4876	290	10	biochemical	biochemical	ADJ
dpc-4876	290	11	factors	factor	NOUN
dpc-4876	290	12	with	with	ADP
dpc-4876	290	13	premature	premature	ADJ
dpc-4876	290	14	graying	graying	NOUN
dpc-4876	290	15	of	of	ADP
dpc-4876	290	16	hair	hair	NOUN
dpc-4876	290	17	:	:	PUNCT
dpc-4876	290	18	a	a	DET
dpc-4876	290	19	casecontrol	casecontrol	NOUN
dpc-4876	290	20	study	study	NOUN
dpc-4876	290	21	.	.	PUNCT
dpc-4876	291	1	int	int	PROPN
dpc-4876	291	2	j	j	PROPN
dpc-4876	291	3	trichology	trichology	PROPN
dpc-4876	291	4	.	.	PUNCT
dpc-4876	292	1	2018	2018	NUM
dpc-4876	292	2	;	;	PUNCT
dpc-4876	292	3	(	(	PUNCT
dpc-4876	292	4	10):211	10):211	NUM
dpc-4876	292	5	-	-	SYM
dpc-4876	292	6	217	217	NUM
dpc-4876	292	7	.	.	PUNCT
dpc-4876	293	1	doi:10.4103	doi:10.4103	PROPN
dpc-4876	293	2	/ijt.ijt_39_18	/ijt.ijt_39_18	PUNCT
dpc-4876	294	1	7	7	X
dpc-4876	294	2	.	.	PUNCT
dpc-4876	294	3	shin	shin	PROPN
dpc-4876	294	4	h	h	PROPN
dpc-4876	294	5	,	,	PUNCT
dpc-4876	294	6	ryu	ryu	PROPN
dpc-4876	294	7	hh	hh	PROPN
dpc-4876	294	8	,	,	PUNCT
dpc-4876	294	9	yoon	yoon	PROPN
dpc-4876	294	10	j	j	PROPN
dpc-4876	294	11	,	,	PUNCT
dpc-4876	294	12	et	et	PROPN
dpc-4876	294	13	al	al	PROPN
dpc-4876	294	14	.	.	PROPN
dpc-4876	294	15	association	association	PROPN
dpc-4876	294	16	of	of	ADP
dpc-4876	294	17	premature	premature	ADJ
dpc-4876	294	18	hair	hair	NOUN
dpc-4876	294	19	graying	gray	VERB
dpc-4876	294	20	with	with	ADP
dpc-4876	294	21	family	family	NOUN
dpc-4876	294	22	history	history	NOUN
dpc-4876	294	23	,	,	PUNCT
dpc-4876	294	24	smoking	smoking	NOUN
dpc-4876	294	25	,	,	PUNCT
dpc-4876	294	26	and	and	CCONJ
dpc-4876	294	27	obesity	obesity	NOUN
dpc-4876	294	28	:	:	PUNCT
dpc-4876	294	29	a	a	DET
dpc-4876	294	30	cross	cross	ADJ
dpc-4876	294	31	-	-	ADJ
dpc-4876	294	32	sectional	sectional	ADJ
dpc-4876	294	33	study	study	NOUN
dpc-4876	294	34	.	.	PUNCT
dpc-4876	295	1	j	j	PROPN
dpc-4876	295	2	am	be	AUX
dpc-4876	295	3	acad	acad	ADJ
dpc-4876	295	4	dermatol	dermatol	NOUN
dpc-4876	295	5	.	.	PUNCT
dpc-4876	296	1	2015	2015	NUM
dpc-4876	296	2	;	;	PUNCT
dpc-4876	296	3	(	(	PUNCT
dpc-4876	296	4	72):321	72):321	NUM
dpc-4876	296	5	-	-	SYM
dpc-4876	296	6	327	327	NUM
dpc-4876	296	7	.	.	PUNCT
dpc-4876	297	1	doi:10.1016	doi:10.1016	PROPN
dpc-4876	297	2	/j.jaad.2014.11.008	/j.jaad.2014.11.008	PUNCT
dpc-4876	298	1	..	..	PUNCT
dpc-4876	298	2	8	8	X
dpc-4876	298	3	.	.	PUNCT
dpc-4876	299	1	adhikari	adhikari	PROPN
dpc-4876	299	2	k	k	PROPN
dpc-4876	299	3	,	,	PUNCT
dpc-4876	299	4	fontanil	fontanil	PROPN
dpc-4876	299	5	t	t	PROPN
dpc-4876	299	6	,	,	PUNCT
dpc-4876	299	7	cal	cal	PROPN
dpc-4876	299	8	s	s	PROPN
dpc-4876	299	9	,	,	PUNCT
dpc-4876	299	10	et	et	PROPN
dpc-4876	299	11	al	al	PROPN
dpc-4876	299	12	.	.	PUNCT
dpc-4876	300	1	a	a	DET
dpc-4876	300	2	genome	genome	NOUN
dpc-4876	300	3	-	-	PUNCT
dpc-4876	300	4	wide	wide	ADJ
dpc-4876	300	5	association	association	NOUN
dpc-4876	300	6	scan	scan	NOUN
dpc-4876	300	7	in	in	ADP
dpc-4876	300	8	admixed	admix	VERB
dpc-4876	300	9	latin	latin	ADJ
dpc-4876	300	10	americans	americans	PROPN
dpc-4876	300	11	identifies	identify	VERB
dpc-4876	300	12	loci	locus	NOUN
dpc-4876	300	13	influencing	influence	VERB
dpc-4876	300	14	facial	facial	ADJ
dpc-4876	300	15	and	and	CCONJ
dpc-4876	300	16	scalp	scalp	NOUN
dpc-4876	300	17	hair	hair	NOUN
dpc-4876	300	18	features	feature	NOUN
dpc-4876	300	19	.	.	PUNCT
dpc-4876	301	1	nat	nat	PROPN
dpc-4876	301	2	.	.	PUNCT
dpc-4876	302	1	commun	commun	PROPN
dpc-4876	302	2	.	.	PUNCT
dpc-4876	303	1	2016	2016	NUM
dpc-4876	303	2	;	;	PUNCT
dpc-4876	303	3	(	(	PUNCT
dpc-4876	303	4	7):10815	7):10815	NOUN
dpc-4876	303	5	.	.	PUNCT
dpc-4876	303	6	doi:10.1038	doi:10.1038	PROPN
dpc-4876	303	7	/	/	SYM
dpc-4876	303	8	ncomms10815	ncomms10815	PROPN
dpc-4876	303	9	.	.	PUNCT
dpc-4876	304	1	9	9	X
dpc-4876	304	2	.	.	X
dpc-4876	304	3	nigam	nigam	PROPN
dpc-4876	304	4	pk	pk	PROPN
dpc-4876	304	5	,	,	PUNCT
dpc-4876	304	6	nigam	nigam	PROPN
dpc-4876	304	7	p.	p.	NOUN
dpc-4876	304	8	premature	premature	ADJ
dpc-4876	304	9	greying	greying	NOUN
dpc-4876	304	10	of	of	ADP
dpc-4876	304	11	hair	hair	NOUN
dpc-4876	304	12	(	(	PUNCT
dpc-4876	304	13	premature	premature	ADJ
dpc-4876	304	14	canities	canitie	NOUN
dpc-4876	304	15	):	):	PUNCT
dpc-4876	304	16	a	a	DET
dpc-4876	304	17	concern	concern	NOUN
dpc-4876	304	18	for	for	ADP
dpc-4876	304	19	parent	parent	NOUN
dpc-4876	304	20	and	and	CCONJ
dpc-4876	304	21	child	child	NOUN
dpc-4876	304	22	.	.	PUNCT
dpc-4876	305	1	j.	j.	PROPN
dpc-4876	305	2	pigment	pigment	PROPN
dpc-4876	305	3	.	.	PUNCT
dpc-4876	306	1	disord	disord	PROPN
dpc-4876	306	2	.	.	PUNCT
dpc-4876	307	1	2017	2017	NUM
dpc-4876	307	2	;	;	PUNCT
dpc-4876	307	3	(	(	PUNCT
dpc-4876	307	4	4):260	4):260	NOUN
dpc-4876	307	5	.	.	PUNCT
dpc-4876	307	6	doi:10.4172/2376	doi:10.4172/2376	NOUN
dpc-4876	307	7	-	-	PUNCT
dpc-4876	307	8	0427.1000260	0427.1000260	NOUN
dpc-4876	307	9	.	.	PUNCT
dpc-4876	308	1	10	10	NUM
dpc-4876	308	2	.	.	PUNCT
dpc-4876	309	1	liu	liu	PROPN
dpc-4876	309	2	h	h	PROPN
dpc-4876	309	3	,	,	PUNCT
dpc-4876	309	4	he	he	PRON
dpc-4876	309	5	z	z	PROPN
dpc-4876	309	6	,	,	PUNCT
dpc-4876	309	7	von	von	PROPN
dpc-4876	309	8	rütte	rütte	PROPN
dpc-4876	309	9	t	t	PROPN
dpc-4876	309	10	,	,	PUNCT
dpc-4876	309	11	yousefi	yousefi	PROPN
dpc-4876	309	12	s	s	PROPN
dpc-4876	309	13	,	,	PUNCT
dpc-4876	309	14	hunger	hunger	NOUN
dpc-4876	309	15	re	re	NOUN
dpc-4876	309	16	,	,	PUNCT
dpc-4876	309	17	simon	simon	PROPN
dpc-4876	309	18	h	h	PROPN
dpc-4876	309	19	-	-	PUNCT
dpc-4876	309	20	u.	u.	VERB
dpc-4876	309	21	down	down	ADP
dpc-4876	309	22	-	-	PUNCT
dpc-4876	309	23	regulation	regulation	NOUN
dpc-4876	309	24	of	of	ADP
dpc-4876	309	25	autophagy	autophagy	ADV
dpc-4876	309	26	-	-	PUNCT
dpc-4876	309	27	related	relate	VERB
dpc-4876	309	28	protein	protein	NOUN
dpc-4876	309	29	5	5	NUM
dpc-4876	309	30	(	(	PUNCT
dpc-4876	309	31	atg5	atg5	PROPN
dpc-4876	309	32	)	)	PUNCT
dpc-4876	309	33	contributes	contribute	VERB
dpc-4876	309	34	to	to	ADP
dpc-4876	309	35	the	the	DET
dpc-4876	309	36	pathogenesis	pathogenesis	NOUN
dpc-4876	309	37	of	of	ADP
dpc-4876	309	38	early	early	ADJ
dpc-4876	309	39	-	-	PUNCT
dpc-4876	309	40	stage	stage	NOUN
dpc-4876	309	41	cutaneous	cutaneous	ADJ
dpc-4876	309	42	melanoma	melanoma	NOUN
dpc-4876	309	43	.	.	PUNCT
dpc-4876	310	1	sci	sci	PROPN
dpc-4876	310	2	transl	transl	PROPN
dpc-4876	310	3	med	med	PROPN
dpc-4876	310	4	.	.	PUNCT
dpc-4876	310	5	2013	2013	NUM
dpc-4876	310	6	;	;	PUNCT
dpc-4876	310	7	(	(	PUNCT
dpc-4876	310	8	5):202ra123	5):202ra123	NOUN
dpc-4876	310	9	.	.	PUNCT
dpc-4876	311	1	doi:10.1126	doi:10.1126	PROPN
dpc-4876	311	2	/	/	SYM
dpc-4876	311	3	scitranslmed	scitranslme	VERB
dpc-4876	311	4	.3005864	.3005864	PROPN
dpc-4876	311	5	.	.	PUNCT
dpc-4876	312	1	11	11	NUM
dpc-4876	312	2	.	.	PUNCT
dpc-4876	313	1	tekirdag	tekirdag	PROPN
dpc-4876	313	2	k	k	PROPN
dpc-4876	313	3	,	,	PUNCT
dpc-4876	313	4	cuervo	cuervo	PROPN
dpc-4876	313	5	am	be	AUX
dpc-4876	313	6	.	.	PUNCT
dpc-4876	314	1	chaperone	chaperone	NOUN
dpc-4876	314	2	-	-	PUNCT
dpc-4876	314	3	mediated	mediate	VERB
dpc-4876	314	4	autophagy	autophagy	NOUN
dpc-4876	314	5	and	and	CCONJ
dpc-4876	314	6	endosomal	endosomal	ADJ
dpc-4876	314	7	microautophagy	microautophagy	NOUN
dpc-4876	314	8	:	:	PUNCT
dpc-4876	314	9	joint	joint	NOUN
dpc-4876	314	10	by	by	ADP
dpc-4876	314	11	a	a	DET
dpc-4876	314	12	chaperone	chaperone	NOUN
dpc-4876	314	13	.	.	PUNCT
dpc-4876	315	1	j.	j.	PROPN
dpc-4876	315	2	biol	biol	PROPN
dpc-4876	315	3	.	.	PUNCT
dpc-4876	316	1	chem	chem	NOUN
dpc-4876	316	2	.	.	PUNCT
dpc-4876	317	1	2018	2018	NUM
dpc-4876	317	2	;	;	PUNCT
dpc-4876	317	3	(	(	PUNCT
dpc-4876	317	4	293):5414	293):5414	NUM
dpc-4876	317	5	-	-	SYM
dpc-4876	317	6	5424	5424	NUM
dpc-4876	317	7	.	.	PUNCT
dpc-4876	318	1	doi:10.1074	doi:10.1074	PROPN
dpc-4876	318	2	/	/	SYM
dpc-4876	319	1	jbc.r117.818237	jbc.r117.818237	INTJ
dpc-4876	319	2	.	.	PUNCT
dpc-4876	320	1	12	12	NUM
dpc-4876	320	2	.	.	PUNCT
dpc-4876	321	1	ramkumar	ramkumar	PROPN
dpc-4876	321	2	a	a	PRON
dpc-4876	321	3	,	,	PUNCT
dpc-4876	321	4	murthy	murthy	PROPN
dpc-4876	321	5	d	d	PROPN
dpc-4876	321	6	,	,	PUNCT
dpc-4876	321	7	raja	raja	PROPN
dpc-4876	321	8	da	da	PROPN
dpc-4876	321	9	,	,	PUNCT
dpc-4876	321	10	et	et	PROPN
dpc-4876	321	11	al	al	PROPN
dpc-4876	321	12	.	.	PUNCT
dpc-4876	322	1	classical	classical	ADJ
dpc-4876	322	2	autophagy	autophagy	ADJ
dpc-4876	322	3	proteins	protein	NOUN
dpc-4876	322	4	lc3b	lc3b	NOUN
dpc-4876	322	5	and	and	CCONJ
dpc-4876	322	6	atg4b	atg4b	DET
dpc-4876	322	7	facilitate	facilitate	NOUN
dpc-4876	322	8	melanosome	melanosome	NOUN
dpc-4876	322	9	movement	movement	NOUN
dpc-4876	322	10	on	on	ADP
dpc-4876	322	11	cytoskeletal	cytoskeletal	ADJ
dpc-4876	322	12	tracks	track	NOUN
dpc-4876	322	13	.	.	PUNCT
dpc-4876	323	1	autophagy	autophagy	VERB
dpc-4876	323	2	.	.	PUNCT
dpc-4876	324	1	2017	2017	NUM
dpc-4876	324	2	;	;	PUNCT
dpc-4876	324	3	(	(	PUNCT
dpc-4876	324	4	13):1331	13):1331	NUM
dpc-4876	324	5	-	-	SYM
dpc-4876	324	6	1347	1347	NUM
dpc-4876	324	7	.	.	PUNCT
dpc-4876	325	1	doi:10	doi:10	PROPN
dpc-4876	325	2	.	.	PUNCT
dpc-4876	326	1	1080/15548627.2017.1327509	1080/15548627.2017.1327509	NUM
dpc-4876	326	2	.	.	NOUN
dpc-4876	326	3	13	13	NUM
dpc-4876	326	4	.	.	PUNCT
dpc-4876	327	1	murase	murase	NOUN
dpc-4876	327	2	d	d	PROPN
dpc-4876	327	3	,	,	PUNCT
dpc-4876	327	4	hachiya	hachiya	PROPN
dpc-4876	327	5	a	a	PRON
dpc-4876	327	6	,	,	PUNCT
dpc-4876	327	7	fullenkamp	fullenkamp	NOUN
dpc-4876	327	8	r	r	NOUN
dpc-4876	327	9	,	,	PUNCT
dpc-4876	327	10	et	et	PROPN
dpc-4876	327	11	al	al	PROPN
dpc-4876	327	12	.	.	PROPN
dpc-4876	327	13	variation	variation	NOUN
dpc-4876	327	14	in	in	ADP
dpc-4876	327	15	hsp70	hsp70	NOUN
dpc-4876	327	16	-	-	ADJ
dpc-4876	327	17	1a	1a	NOUN
dpc-4876	327	18	expression	expression	NOUN
dpc-4876	327	19	contributes	contribute	VERB
dpc-4876	327	20	to	to	ADP
dpc-4876	327	21	skin	skin	NOUN
dpc-4876	327	22	color	color	NOUN
dpc-4876	327	23	diversity	diversity	NOUN
dpc-4876	327	24	.	.	PUNCT
dpc-4876	328	1	j.	j.	PROPN
dpc-4876	328	2	invest	invest	PROPN
dpc-4876	328	3	.	.	PUNCT
dpc-4876	329	1	dermatol	dermatol	NOUN
dpc-4876	329	2	.	.	PUNCT
dpc-4876	330	1	2016	2016	NUM
dpc-4876	330	2	;	;	PUNCT
dpc-4876	330	3	(	(	PUNCT
dpc-4876	330	4	136):1681	136):1681	NUM
dpc-4876	330	5	-	-	SYM
dpc-4876	330	6	1691	1691	NUM
dpc-4876	330	7	.	.	PUNCT
dpc-4876	331	1	doi:10.1016	doi:10.1016	PROPN
dpc-4876	331	2	/	/	SYM
dpc-4876	331	3	j.jid.2016	j.jid.2016	PROPN
dpc-4876	331	4	.03.038	.03.038	NOUN
dpc-4876	331	5	.	.	PUNCT
dpc-4876	332	1	14	14	NUM
dpc-4876	332	2	.	.	PUNCT
dpc-4876	333	1	kabeya	kabeya	PROPN
dpc-4876	333	2	y	y	PROPN
dpc-4876	333	3	,	,	PUNCT
dpc-4876	333	4	mizushima	mizushima	PROPN
dpc-4876	333	5	n	n	CCONJ
dpc-4876	333	6	,	,	PUNCT
dpc-4876	333	7	ueno	ueno	PROPN
dpc-4876	333	8	t	t	PROPN
dpc-4876	333	9	,	,	PUNCT
dpc-4876	333	10	et	et	PROPN
dpc-4876	333	11	al	al	PROPN
dpc-4876	333	12	.	.	PROPN
dpc-4876	333	13	lc3	lc3	PROPN
dpc-4876	333	14	,	,	PUNCT
dpc-4876	333	15	a	a	DET
dpc-4876	333	16	mammalian	mammalian	ADJ
dpc-4876	333	17	homologue	homologue	NOUN
dpc-4876	333	18	of	of	ADP
dpc-4876	333	19	yeast	yeast	NOUN
dpc-4876	333	20	apg8p	apg8p	PROPN
dpc-4876	333	21	,	,	PUNCT
dpc-4876	333	22	is	be	AUX
dpc-4876	333	23	localized	localize	VERB
dpc-4876	333	24	in	in	ADP
dpc-4876	333	25	autophagosome	autophagosome	NOUN
dpc-4876	333	26	membranes	membrane	NOUN
dpc-4876	333	27	after	after	ADP
dpc-4876	333	28	processing	processing	NOUN
dpc-4876	333	29	.	.	PUNCT
dpc-4876	334	1	the	the	DET
dpc-4876	334	2	embo	embo	PROPN
dpc-4876	334	3	journal	journal	PROPN
dpc-4876	334	4	.	.	PUNCT
dpc-4876	334	5	2000	2000	NUM
dpc-4876	334	6	;	;	PUNCT
dpc-4876	334	7	(	(	PUNCT
dpc-4876	334	8	19):5720	19):5720	NUM
dpc-4876	334	9	-	-	SYM
dpc-4876	334	10	5728	5728	NUM
dpc-4876	334	11	.	.	PUNCT
dpc-4876	335	1	doi:10.1093	doi:10.1093	NOUN
dpc-4876	335	2	/	/	SYM
dpc-4876	335	3	emboj/19.21.5720	emboj/19.21.5720	NOUN
dpc-4876	335	4	.	.	PUNCT