id	sid	tid	token	lemma	pos
dpc-4952	1	1	dermatology	dermatology	NOUN
dpc-4952	1	2	:	:	PUNCT
dpc-4952	1	3	practical	practical	ADJ
dpc-4952	1	4	and	and	CCONJ
dpc-4952	1	5	conceptual	conceptual	ADJ
dpc-4952	1	6	original	original	ADJ
dpc-4952	1	7	article	article	NOUN
dpc-4952	1	8	|	|	ADV
dpc-4952	1	9	dermatol	dermatol	ADJ
dpc-4952	1	10	pract	pract	NOUN
dpc-4952	1	11	concept	concept	NOUN
dpc-4952	1	12	.	.	PUNCT
dpc-4952	2	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	2	2	1	1	NUM
dpc-4952	2	3	melanoma	melanoma	NOUN
dpc-4952	2	4	on	on	ADP
dpc-4952	2	5	chronically	chronically	ADV
dpc-4952	2	6	sun	sun	NOUN
dpc-4952	2	7	-	-	PUNCT
dpc-4952	2	8	damaged	damage	VERB
dpc-4952	2	9	skin	skin	NOUN
dpc-4952	2	10	:	:	PUNCT
dpc-4952	2	11	deciphering	decipher	VERB
dpc-4952	2	12	gene	gene	NOUN
dpc-4952	2	13	expression	expression	NOUN
dpc-4952	2	14	signatures	signature	NOUN
dpc-4952	2	15	alejandra	alejandra	PROPN
dpc-4952	2	16	avila1	avila1	PROPN
dpc-4952	2	17	*	*	PROPN
dpc-4952	2	18	,	,	PUNCT
dpc-4952	2	19	varsha	varsha	PROPN
dpc-4952	2	20	thakur1,2	thakur1,2	PROPN
dpc-4952	2	21	*	*	PROPN
dpc-4952	2	22	,	,	PUNCT
dpc-4952	2	23	natalie	natalie	PROPN
dpc-4952	2	24	vincent1	vincent1	PROPN
dpc-4952	2	25	,	,	PUNCT
dpc-4952	2	26	pilar	pilar	PROPN
dpc-4952	2	27	valencia1	valencia1	PROPN
dpc-4952	2	28	,	,	PUNCT
dpc-4952	2	29	mecker	mecker	NOUN
dpc-4952	2	30	g.	g.	PROPN
dpc-4952	2	31	möller1,3	möller1,3	PROPN
dpc-4952	2	32	,	,	PUNCT
dpc-4952	3	1	rimpi	rimpi	ADJ
dpc-4952	3	2	khurana2	khurana2	PROPN
dpc-4952	3	3	,	,	PUNCT
dpc-4952	3	4	guo	guo	PROPN
dpc-4952	3	5	yan2	yan2	PROPN
dpc-4952	3	6	,	,	PUNCT
dpc-4952	3	7	jennifer	jennifer	PROPN
dpc-4952	3	8	c.	c.	PROPN
dpc-4952	3	9	tang1,2	tang1,2	PROPN
dpc-4952	3	10	,	,	PUNCT
dpc-4952	3	11	barbara	barbara	PROPN
dpc-4952	3	12	bedogni1,2	bedogni1,2	PROPN
dpc-4952	3	13	,	,	PUNCT
dpc-4952	3	14	natalia	natalia	PROPN
dpc-4952	3	15	jaimes1,2	jaimes1,2	PROPN
dpc-4952	3	16	1	1	NUM
dpc-4952	3	17	dr	dr	PROPN
dpc-4952	3	18	.	.	PROPN
dpc-4952	3	19	phillip	phillip	PROPN
dpc-4952	3	20	frost	frost	PROPN
dpc-4952	3	21	department	department	PROPN
dpc-4952	3	22	of	of	ADP
dpc-4952	3	23	dermatology	dermatology	NOUN
dpc-4952	3	24	&	&	CCONJ
dpc-4952	3	25	cutaneous	cutaneous	ADJ
dpc-4952	3	26	surgery	surgery	NOUN
dpc-4952	3	27	,	,	PUNCT
dpc-4952	3	28	university	university	NOUN
dpc-4952	3	29	of	of	ADP
dpc-4952	3	30	miami	miami	PROPN
dpc-4952	3	31	miller	miller	PROPN
dpc-4952	3	32	school	school	PROPN
dpc-4952	3	33	of	of	ADP
dpc-4952	3	34	medicine	medicine	NOUN
dpc-4952	3	35	,	,	PUNCT
dpc-4952	3	36	miami	miami	PROPN
dpc-4952	3	37	,	,	PUNCT
dpc-4952	3	38	florida	florida	PROPN
dpc-4952	3	39	,	,	PUNCT
dpc-4952	3	40	usa	usa	PROPN
dpc-4952	3	41	2	2	NUM
dpc-4952	3	42	sylvester	sylvester	PROPN
dpc-4952	3	43	comprehensive	comprehensive	ADJ
dpc-4952	3	44	cancer	cancer	NOUN
dpc-4952	3	45	center	center	NOUN
dpc-4952	3	46	,	,	PUNCT
dpc-4952	3	47	university	university	PROPN
dpc-4952	3	48	of	of	ADP
dpc-4952	3	49	miami	miami	PROPN
dpc-4952	3	50	health	health	NOUN
dpc-4952	3	51	system	system	NOUN
dpc-4952	3	52	,	,	PUNCT
dpc-4952	3	53	miami	miami	PROPN
dpc-4952	3	54	,	,	PUNCT
dpc-4952	3	55	florida	florida	PROPN
dpc-4952	3	56	,	,	PUNCT
dpc-4952	3	57	usa	usa	PROPN
dpc-4952	3	58	3	3	PROPN
dpc-4952	3	59	pritzker	pritzker	PROPN
dpc-4952	3	60	school	school	PROPN
dpc-4952	3	61	of	of	ADP
dpc-4952	3	62	medicine	medicine	NOUN
dpc-4952	3	63	,	,	PUNCT
dpc-4952	3	64	university	university	NOUN
dpc-4952	3	65	of	of	ADP
dpc-4952	3	66	chicago	chicago	PROPN
dpc-4952	3	67	,	,	PUNCT
dpc-4952	3	68	illinois	illinois	PROPN
dpc-4952	3	69	,	,	PUNCT
dpc-4952	3	70	usa	usa	PROPN
dpc-4952	3	71	*	*	PUNCT
dpc-4952	3	72	equal	equal	ADJ
dpc-4952	3	73	contribution	contribution	NOUN
dpc-4952	3	74	key	key	ADJ
dpc-4952	3	75	words	word	NOUN
dpc-4952	3	76	:	:	PUNCT
dpc-4952	3	77	melanoma	melanoma	NOUN
dpc-4952	3	78	,	,	PUNCT
dpc-4952	3	79	gene	gene	NOUN
dpc-4952	3	80	expression	expression	NOUN
dpc-4952	3	81	,	,	PUNCT
dpc-4952	3	82	ultraviolet	ultraviolet	ADJ
dpc-4952	3	83	radiation	radiation	NOUN
dpc-4952	3	84	,	,	PUNCT
dpc-4952	3	85	sequence	sequence	NOUN
dpc-4952	3	86	analysis	analysis	NOUN
dpc-4952	3	87	rna	rna	NOUN
dpc-4952	3	88	,	,	PUNCT
dpc-4952	3	89	inflammation	inflammation	NOUN
dpc-4952	3	90	,	,	PUNCT
dpc-4952	3	91	sun	sun	NOUN
dpc-4952	3	92	-	-	PUNCT
dpc-4952	3	93	damaged	damage	VERB
dpc-4952	3	94	skin	skin	NOUN
dpc-4952	3	95	citation	citation	NOUN
dpc-4952	3	96	:	:	PUNCT
dpc-4952	3	97	avila	avila	PROPN
dpc-4952	3	98	a	a	PROPN
dpc-4952	3	99	,	,	PUNCT
dpc-4952	3	100	thakur	thakur	PROPN
dpc-4952	3	101	v	v	PROPN
dpc-4952	3	102	,	,	PUNCT
dpc-4952	3	103	vincent	vincent	PROPN
dpc-4952	3	104	n	n	CCONJ
dpc-4952	3	105	,	,	PUNCT
dpc-4952	3	106	et	et	PROPN
dpc-4952	3	107	al	al	PROPN
dpc-4952	3	108	.	.	PUNCT
dpc-4952	3	109	melanoma	melanoma	PROPN
dpc-4952	3	110	on	on	ADP
dpc-4952	3	111	chronically	chronically	ADV
dpc-4952	3	112	sun	sun	NOUN
dpc-4952	3	113	-	-	PUNCT
dpc-4952	3	114	damaged	damage	VERB
dpc-4952	3	115	skin	skin	NOUN
dpc-4952	3	116	:	:	PUNCT
dpc-4952	3	117	deciphering	decipher	VERB
dpc-4952	3	118	gene	gene	NOUN
dpc-4952	3	119	expression	expression	NOUN
dpc-4952	3	120	signatures	signature	NOUN
dpc-4952	3	121	.	.	PUNCT
dpc-4952	4	1	dermatol	dermatol	NOUN
dpc-4952	4	2	pract	pract	PROPN
dpc-4952	4	3	concept	concept	NOUN
dpc-4952	4	4	.	.	PUNCT
dpc-4952	5	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	5	2	.	.	PUNCT
dpc-4952	6	1	doi	doi	PROPN
dpc-4952	6	2	:	:	PUNCT
dpc-4952	6	3	https://doi.org/10.5826/dpc.1502a4952	https://doi.org/10.5826/dpc.1502a4952	PROPN
dpc-4952	6	4	accepted	accept	VERB
dpc-4952	6	5	:	:	PUNCT
dpc-4952	6	6	january	january	PROPN
dpc-4952	6	7	7	7	NUM
dpc-4952	6	8	,	,	PUNCT
dpc-4952	6	9	2025	2025	NUM
dpc-4952	6	10	;	;	PUNCT
dpc-4952	6	11	published	publish	VERB
dpc-4952	6	12	:	:	PUNCT
dpc-4952	7	1	april	april	PROPN
dpc-4952	7	2	2025	2025	NUM
dpc-4952	7	3	copyright	copyright	NOUN
dpc-4952	7	4	:	:	PUNCT
dpc-4952	8	1	©	©	PROPN
dpc-4952	8	2	2025	2025	NUM
dpc-4952	8	3	avila	avila	PROPN
dpc-4952	8	4	et	et	PROPN
dpc-4952	8	5	al	al	PROPN
dpc-4952	8	6	.	.	PUNCT
dpc-4952	9	1	this	this	PRON
dpc-4952	9	2	is	be	AUX
dpc-4952	9	3	an	an	DET
dpc-4952	9	4	open	open	ADJ
dpc-4952	9	5	-	-	PUNCT
dpc-4952	9	6	access	access	NOUN
dpc-4952	9	7	article	article	NOUN
dpc-4952	9	8	distributed	distribute	VERB
dpc-4952	9	9	under	under	ADP
dpc-4952	9	10	the	the	DET
dpc-4952	9	11	terms	term	NOUN
dpc-4952	9	12	of	of	ADP
dpc-4952	9	13	the	the	DET
dpc-4952	9	14	creative	creative	ADJ
dpc-4952	9	15	commons	common	NOUN
dpc-4952	9	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-4952	9	17	license	license	NOUN
dpc-4952	9	18	(	(	PUNCT
dpc-4952	9	19	by	by	ADP
dpc-4952	9	20	-	-	PUNCT
dpc-4952	9	21	nc-4.0	nc-4.0	NOUN
dpc-4952	9	22	)	)	PUNCT
dpc-4952	9	23	,	,	PUNCT
dpc-4952	9	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-4952	9	25	,	,	PUNCT
dpc-4952	9	26	which	which	PRON
dpc-4952	9	27	permits	permit	VERB
dpc-4952	9	28	unrestricted	unrestricted	ADJ
dpc-4952	9	29	noncommercial	noncommercial	ADJ
dpc-4952	9	30	use	use	NOUN
dpc-4952	9	31	,	,	PUNCT
dpc-4952	9	32	distribution	distribution	NOUN
dpc-4952	9	33	,	,	PUNCT
dpc-4952	9	34	and	and	CCONJ
dpc-4952	9	35	reproduction	reproduction	NOUN
dpc-4952	9	36	in	in	ADP
dpc-4952	9	37	any	any	DET
dpc-4952	9	38	medium	medium	NOUN
dpc-4952	9	39	,	,	PUNCT
dpc-4952	9	40	provided	provide	VERB
dpc-4952	9	41	the	the	DET
dpc-4952	9	42	original	original	ADJ
dpc-4952	9	43	authors	author	NOUN
dpc-4952	9	44	and	and	CCONJ
dpc-4952	9	45	source	source	NOUN
dpc-4952	9	46	are	be	AUX
dpc-4952	9	47	credited	credit	VERB
dpc-4952	9	48	.	.	PUNCT
dpc-4952	10	1	funding	funding	NOUN
dpc-4952	10	2	:	:	PUNCT
dpc-4952	10	3	none	none	NOUN
dpc-4952	10	4	.	.	PUNCT
dpc-4952	11	1	competing	compete	VERB
dpc-4952	11	2	interests	interest	NOUN
dpc-4952	11	3	:	:	PUNCT
dpc-4952	11	4	none	none	NOUN
dpc-4952	11	5	.	.	PUNCT
dpc-4952	12	1	authorship	authorship	NOUN
dpc-4952	12	2	:	:	PUNCT
dpc-4952	12	3	all	all	DET
dpc-4952	12	4	authors	author	NOUN
dpc-4952	12	5	have	have	AUX
dpc-4952	12	6	contributed	contribute	VERB
dpc-4952	12	7	significantly	significantly	ADV
dpc-4952	12	8	to	to	ADP
dpc-4952	12	9	this	this	DET
dpc-4952	12	10	publication	publication	NOUN
dpc-4952	12	11	.	.	PUNCT
dpc-4952	13	1	acknowledgments	acknowledgment	NOUN
dpc-4952	13	2	:	:	PUNCT
dpc-4952	13	3	valeria	valeria	PROPN
dpc-4952	13	4	de	de	PROPN
dpc-4952	13	5	bedout	bedout	PROPN
dpc-4952	13	6	,	,	PUNCT
dpc-4952	13	7	md	md	PROPN
dpc-4952	13	8	for	for	ADP
dpc-4952	13	9	her	her	PRON
dpc-4952	13	10	support	support	NOUN
dpc-4952	13	11	with	with	ADP
dpc-4952	13	12	sample	sample	NOUN
dpc-4952	13	13	collection	collection	NOUN
dpc-4952	13	14	.	.	PUNCT
dpc-4952	14	1	corresponding	correspond	VERB
dpc-4952	14	2	author	author	NOUN
dpc-4952	14	3	:	:	PUNCT
dpc-4952	14	4	natalia	natalia	PROPN
dpc-4952	14	5	jaimes	jaimes	PROPN
dpc-4952	14	6	,	,	PUNCT
dpc-4952	14	7	md	md	PROPN
dpc-4952	14	8	,	,	PUNCT
dpc-4952	14	9	dr	dr	PROPN
dpc-4952	14	10	.	.	PROPN
dpc-4952	14	11	phillip	phillip	PROPN
dpc-4952	14	12	frost	frost	PROPN
dpc-4952	14	13	department	department	PROPN
dpc-4952	14	14	of	of	ADP
dpc-4952	14	15	dermatology	dermatology	NOUN
dpc-4952	14	16	&	&	CCONJ
dpc-4952	14	17	cutaneous	cutaneous	ADJ
dpc-4952	14	18	surgery	surgery	NOUN
dpc-4952	14	19	.	.	PUNCT
dpc-4952	15	1	university	university	NOUN
dpc-4952	15	2	of	of	ADP
dpc-4952	15	3	miami	miami	PROPN
dpc-4952	15	4	miller	miller	PROPN
dpc-4952	15	5	school	school	PROPN
dpc-4952	15	6	of	of	ADP
dpc-4952	15	7	medicinen	medicinen	PROPN
dpc-4952	15	8	and	and	CCONJ
dpc-4952	15	9	sylvester	sylvest	ADJ
dpc-4952	15	10	comprehensive	comprehensive	ADJ
dpc-4952	15	11	cancer	cancer	NOUN
dpc-4952	15	12	center	center	NOUN
dpc-4952	15	13	,	,	PUNCT
dpc-4952	15	14	university	university	PROPN
dpc-4952	15	15	of	of	ADP
dpc-4952	15	16	miami	miami	PROPN
dpc-4952	15	17	health	health	NOUN
dpc-4952	15	18	system	system	NOUN
dpc-4952	15	19	,	,	PUNCT
dpc-4952	15	20	miami	miami	PROPN
dpc-4952	15	21	,	,	PUNCT
dpc-4952	15	22	fl	fl	PROPN
dpc-4952	15	23	.	.	PROPN
dpc-4952	15	24	orcid	orcid	PROPN
dpc-4952	16	1	i	i	PRON
dpc-4952	16	2	d	d	NOUN
dpc-4952	16	3	:	:	PUNCT
dpc-4952	16	4	0000	0000	NUM
dpc-4952	16	5	-	-	PUNCT
dpc-4952	16	6	0002	0002	NUM
dpc-4952	16	7	-	-	PUNCT
dpc-4952	16	8	3651	3651	NUM
dpc-4952	16	9	-	-	PUNCT
dpc-4952	16	10	1019	1019	NUM
dpc-4952	16	11	,	,	PUNCT
dpc-4952	16	12	e	e	NOUN
dpc-4952	16	13	-	-	NOUN
dpc-4952	16	14	mail	mail	NOUN
dpc-4952	16	15	:	:	PUNCT
dpc-4952	16	16	nmw50@med.miami.edu	nmw50@med.miami.edu	SYM
dpc-4952	16	17	introduction	introduction	NOUN
dpc-4952	16	18	:	:	PUNCT
dpc-4952	16	19	melanoma	melanoma	NOUN
dpc-4952	16	20	of	of	ADP
dpc-4952	16	21	the	the	DET
dpc-4952	16	22	skin	skin	NOUN
dpc-4952	16	23	is	be	AUX
dpc-4952	16	24	responsible	responsible	ADJ
dpc-4952	16	25	for	for	ADP
dpc-4952	16	26	most	most	ADJ
dpc-4952	16	27	skin	skin	NOUN
dpc-4952	16	28	cancer	cancer	NOUN
dpc-4952	16	29	-	-	PUNCT
dpc-4952	16	30	related	relate	VERB
dpc-4952	16	31	deaths	death	NOUN
dpc-4952	16	32	.	.	PUNCT
dpc-4952	17	1	it	it	PRON
dpc-4952	17	2	is	be	AUX
dpc-4952	17	3	well	well	ADV
dpc-4952	17	4	known	know	VERB
dpc-4952	17	5	that	that	DET
dpc-4952	17	6	exposure	exposure	NOUN
dpc-4952	17	7	to	to	ADP
dpc-4952	17	8	ultraviolet	ultraviolet	ADJ
dpc-4952	17	9	radiation	radiation	NOUN
dpc-4952	17	10	is	be	AUX
dpc-4952	17	11	the	the	DET
dpc-4952	17	12	most	most	ADV
dpc-4952	17	13	common	common	ADJ
dpc-4952	17	14	and	and	CCONJ
dpc-4952	17	15	modifiable	modifiable	ADJ
dpc-4952	17	16	risk	risk	NOUN
dpc-4952	17	17	factor	factor	NOUN
dpc-4952	17	18	for	for	ADP
dpc-4952	17	19	melanoma	melanoma	NOUN
dpc-4952	17	20	.	.	PUNCT
dpc-4952	18	1	melanomas	melanoma	NOUN
dpc-4952	18	2	arising	arise	VERB
dpc-4952	18	3	on	on	ADP
dpc-4952	18	4	chronically	chronically	ADV
dpc-4952	18	5	sun	sun	NOUN
dpc-4952	18	6	-	-	PUNCT
dpc-4952	18	7	damaged	damage	VERB
dpc-4952	18	8	skin	skin	NOUN
dpc-4952	18	9	(	(	PUNCT
dpc-4952	18	10	csds	csds	NOUN
dpc-4952	18	11	)	)	PUNCT
dpc-4952	18	12	have	have	AUX
dpc-4952	18	13	shown	show	VERB
dpc-4952	18	14	a	a	DET
dpc-4952	18	15	higher	high	ADJ
dpc-4952	18	16	mutational	mutational	ADJ
dpc-4952	18	17	burden	burden	NOUN
dpc-4952	18	18	.	.	PUNCT
dpc-4952	19	1	objectives	objective	NOUN
dpc-4952	19	2	:	:	PUNCT
dpc-4952	19	3	to	to	PART
dpc-4952	19	4	analyze	analyze	VERB
dpc-4952	19	5	skin	skin	NOUN
dpc-4952	19	6	samples	sample	NOUN
dpc-4952	19	7	of	of	ADP
dpc-4952	19	8	patients	patient	NOUN
dpc-4952	19	9	with	with	ADP
dpc-4952	19	10	melanoma	melanoma	NOUN
dpc-4952	19	11	on	on	ADP
dpc-4952	19	12	csds	csds	NOUN
dpc-4952	19	13	to	to	PART
dpc-4952	19	14	identify	identify	VERB
dpc-4952	19	15	possible	possible	ADJ
dpc-4952	19	16	gene	gene	NOUN
dpc-4952	19	17	expression	expression	NOUN
dpc-4952	19	18	signatures	signature	NOUN
dpc-4952	19	19	that	that	PRON
dpc-4952	19	20	may	may	AUX
dpc-4952	19	21	contribute	contribute	VERB
dpc-4952	19	22	to	to	ADP
dpc-4952	19	23	melanomagenesis	melanomagenesis	NOUN
dpc-4952	19	24	.	.	PUNCT
dpc-4952	20	1	methods	method	NOUN
dpc-4952	20	2	:	:	PUNCT
dpc-4952	20	3	this	this	DET
dpc-4952	20	4	experimental	experimental	ADJ
dpc-4952	20	5	observational	observational	ADJ
dpc-4952	20	6	analysis	analysis	NOUN
dpc-4952	20	7	,	,	PUNCT
dpc-4952	20	8	conducted	conduct	VERB
dpc-4952	20	9	at	at	ADP
dpc-4952	20	10	the	the	DET
dpc-4952	20	11	dermatology	dermatology	NOUN
dpc-4952	20	12	melanoma	melanoma	NOUN
dpc-4952	20	13	and	and	CCONJ
dpc-4952	20	14	pigmented	pigmented	ADJ
dpc-4952	20	15	lesion	lesion	NOUN
dpc-4952	20	16	clinic	clinic	NOUN
dpc-4952	20	17	at	at	ADP
dpc-4952	20	18	university	university	PROPN
dpc-4952	20	19	of	of	ADP
dpc-4952	20	20	miami	miami	PROPN
dpc-4952	20	21	hospitals	hospitals	PROPN
dpc-4952	20	22	/	/	SYM
dpc-4952	20	23	sylvester	sylvester	PROPN
dpc-4952	20	24	comprehensive	comprehensive	ADJ
dpc-4952	20	25	cancer	cancer	NOUN
dpc-4952	20	26	center	center	NOUN
dpc-4952	20	27	,	,	PUNCT
dpc-4952	20	28	miami	miami	PROPN
dpc-4952	20	29	,	,	PUNCT
dpc-4952	20	30	florida	florida	PROPN
dpc-4952	20	31	,	,	PUNCT
dpc-4952	20	32	included	include	VERB
dpc-4952	20	33	a	a	DET
dpc-4952	20	34	total	total	NOUN
dpc-4952	20	35	of	of	ADP
dpc-4952	20	36	10	10	NUM
dpc-4952	20	37	patients	patient	NOUN
dpc-4952	20	38	over	over	ADP
dpc-4952	20	39	18	18	NUM
dpc-4952	20	40	years	year	NOUN
dpc-4952	20	41	of	of	ADP
dpc-4952	20	42	age	age	NOUN
dpc-4952	20	43	with	with	ADP
dpc-4952	20	44	a	a	DET
dpc-4952	20	45	recent	recent	ADJ
dpc-4952	20	46	diagnosis	diagnosis	NOUN
dpc-4952	20	47	of	of	ADP
dpc-4952	20	48	melanoma	melanoma	NOUN
dpc-4952	20	49	on	on	ADP
dpc-4952	20	50	csds	csds	NOUN
dpc-4952	20	51	.	.	PUNCT
dpc-4952	21	1	for	for	ADP
dpc-4952	21	2	each	each	DET
dpc-4952	21	3	patient	patient	NOUN
dpc-4952	21	4	,	,	PUNCT
dpc-4952	21	5	two	two	NUM
dpc-4952	21	6	skin	skin	NOUN
dpc-4952	21	7	samples	sample	NOUN
dpc-4952	21	8	were	be	AUX
dpc-4952	21	9	obtained	obtain	VERB
dpc-4952	21	10	using	use	VERB
dpc-4952	21	11	a	a	DET
dpc-4952	21	12	2	2	NUM
dpc-4952	21	13	-	-	PUNCT
dpc-4952	21	14	mm	mm	NOUN
dpc-4952	21	15	punch	punch	NOUN
dpc-4952	21	16	(	(	PUNCT
dpc-4952	21	17	one	one	NUM
dpc-4952	21	18	from	from	ADP
dpc-4952	21	19	csds	csds	NOUN
dpc-4952	21	20	within	within	ADP
dpc-4952	21	21	2	2	NUM
dpc-4952	21	22	cm	cm	NOUN
dpc-4952	21	23	of	of	ADP
dpc-4952	21	24	the	the	DET
dpc-4952	21	25	primary	primary	ADJ
dpc-4952	21	26	melanoma	melanoma	NOUN
dpc-4952	21	27	,	,	PUNCT
dpc-4952	21	28	another	another	PRON
dpc-4952	21	29	from	from	ADP
dpc-4952	21	30	sun	sun	NOUN
dpc-4952	21	31	-	-	PUNCT
dpc-4952	21	32	protected	protect	VERB
dpc-4952	21	33	skin	skin	NOUN
dpc-4952	21	34	)	)	PUNCT
dpc-4952	21	35	.	.	PUNCT
dpc-4952	22	1	skin	skin	NOUN
dpc-4952	22	2	samples	sample	NOUN
dpc-4952	22	3	were	be	AUX
dpc-4952	22	4	sent	send	VERB
dpc-4952	22	5	to	to	ADP
dpc-4952	22	6	the	the	DET
dpc-4952	22	7	sylvester	sylvest	ADJ
dpc-4952	22	8	onco	onco	NOUN
dpc-4952	22	9	-	-	PUNCT
dpc-4952	22	10	genomics	genomics	NOUN
dpc-4952	22	11	shared	share	VERB
dpc-4952	22	12	resource	resource	NOUN
dpc-4952	22	13	(	(	PUNCT
dpc-4952	22	14	ogsr	ogsr	NOUN
dpc-4952	22	15	)	)	PUNCT
dpc-4952	22	16	for	for	ADP
dpc-4952	22	17	library	library	ADJ
dpc-4952	22	18	preparation	preparation	NOUN
dpc-4952	22	19	and	and	CCONJ
dpc-4952	22	20	rna	rna	NOUN
dpc-4952	22	21	sequencing	sequencing	NOUN
dpc-4952	22	22	.	.	PUNCT
dpc-4952	22	23	 	 	SPACE
dpc-4952	23	1	main	main	ADJ
dpc-4952	23	2	outcome	outcome	NOUN
dpc-4952	23	3	was	be	AUX
dpc-4952	23	4	the	the	DET
dpc-4952	23	5	identification	identification	NOUN
dpc-4952	23	6	of	of	ADP
dpc-4952	23	7	differentially	differentially	ADV
dpc-4952	23	8	expressed	express	VERB
dpc-4952	23	9	genes	gene	NOUN
dpc-4952	23	10	between	between	ADP
dpc-4952	23	11	csds	csds	NOUN
dpc-4952	23	12	and	and	CCONJ
dpc-4952	23	13	non	non	ADJ
dpc-4952	23	14	-	-	ADJ
dpc-4952	23	15	csds	csds	NOUN
dpc-4952	23	16	of	of	ADP
dpc-4952	23	17	patients	patient	NOUN
dpc-4952	23	18	with	with	ADP
dpc-4952	23	19	a	a	DET
dpc-4952	23	20	recent	recent	ADJ
dpc-4952	23	21	diagnosis	diagnosis	NOUN
dpc-4952	23	22	of	of	ADP
dpc-4952	23	23	melanoma	melanoma	NOUN
dpc-4952	23	24	.	.	PUNCT
dpc-4952	24	1	results	result	NOUN
dpc-4952	24	2	:	:	PUNCT
dpc-4952	24	3	a	a	DET
dpc-4952	24	4	total	total	NOUN
dpc-4952	24	5	of	of	ADP
dpc-4952	24	6	four	four	NUM
dpc-4952	24	7	skin	skin	NOUN
dpc-4952	24	8	samples	sample	NOUN
dpc-4952	24	9	met	meet	VERB
dpc-4952	24	10	the	the	DET
dpc-4952	24	11	necessary	necessary	ADJ
dpc-4952	24	12	quality	quality	NOUN
dpc-4952	24	13	standards	standard	NOUN
dpc-4952	24	14	for	for	ADP
dpc-4952	24	15	molecular	molecular	ADJ
dpc-4952	24	16	analyses	analysis	NOUN
dpc-4952	24	17	.	.	PUNCT
dpc-4952	25	1	significant	significant	ADJ
dpc-4952	25	2	differences	difference	NOUN
dpc-4952	25	3	were	be	AUX
dpc-4952	25	4	observed	observe	VERB
dpc-4952	25	5	between	between	ADP
dpc-4952	25	6	the	the	DET
dpc-4952	25	7	csds	csds	NOUN
dpc-4952	25	8	and	and	CCONJ
dpc-4952	25	9	non	non	ADJ
dpc-4952	25	10	-	-	ADJ
dpc-4952	25	11	csds	csds	ADJ
dpc-4952	25	12	samples	sample	NOUN
dpc-4952	25	13	.	.	PUNCT
dpc-4952	26	1	pathways	pathway	NOUN
dpc-4952	26	2	involved	involve	VERB
dpc-4952	26	3	in	in	ADP
dpc-4952	26	4	inflammation	inflammation	NOUN
dpc-4952	26	5	(	(	PUNCT
dpc-4952	26	6	e.g.	e.g.	ADV
dpc-4952	26	7	,	,	PUNCT
dpc-4952	26	8	il-17	il-17	X
dpc-4952	26	9	signaling	signal	VERB
dpc-4952	26	10	)	)	PUNCT
dpc-4952	26	11	,	,	PUNCT
dpc-4952	26	12	immune	immune	ADJ
dpc-4952	26	13	responses	response	NOUN
dpc-4952	26	14	(	(	PUNCT
dpc-4952	26	15	e.g.	e.g.	ADV
dpc-4952	26	16	,	,	PUNCT
dpc-4952	26	17	abc	abc	PROPN
dpc-4952	26	18	transporters	transporter	NOUN
dpc-4952	26	19	)	)	PUNCT
dpc-4952	26	20	,	,	PUNCT
dpc-4952	26	21	and	and	CCONJ
dpc-4952	26	22	oxidative	oxidative	ADJ
dpc-4952	26	23	phosphorylation	phosphorylation	NOUN
dpc-4952	26	24	were	be	AUX
dpc-4952	26	25	overexpressed	overexpresse	VERB
dpc-4952	26	26	in	in	ADP
dpc-4952	26	27	csds	csds	NOUN
dpc-4952	26	28	.	.	PUNCT
dpc-4952	27	1	abstract	abstract	ADJ
dpc-4952	27	2	2	2	NUM
dpc-4952	27	3	original	original	ADJ
dpc-4952	27	4	article	article	NOUN
dpc-4952	27	5	|	|	ADV
dpc-4952	27	6	dermatol	dermatol	ADJ
dpc-4952	27	7	pract	pract	NOUN
dpc-4952	27	8	concept	concept	NOUN
dpc-4952	27	9	.	.	PUNCT
dpc-4952	28	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	28	2	introduction	introduction	NOUN
dpc-4952	28	3	it	it	PRON
dpc-4952	28	4	is	be	AUX
dpc-4952	28	5	well	well	ADV
dpc-4952	28	6	known	know	VERB
dpc-4952	28	7	that	that	DET
dpc-4952	28	8	exposure	exposure	NOUN
dpc-4952	28	9	to	to	ADP
dpc-4952	28	10	ultraviolet	ultraviolet	ADJ
dpc-4952	28	11	radiation	radiation	NOUN
dpc-4952	28	12	(	(	PUNCT
dpc-4952	28	13	uvr	uvr	NOUN
dpc-4952	28	14	)	)	PUNCT
dpc-4952	28	15	is	be	AUX
dpc-4952	28	16	the	the	DET
dpc-4952	28	17	most	most	ADV
dpc-4952	28	18	common	common	ADJ
dpc-4952	28	19	,	,	PUNCT
dpc-4952	28	20	modifiable	modifiable	ADJ
dpc-4952	28	21	,	,	PUNCT
dpc-4952	28	22	environmental	environmental	ADJ
dpc-4952	28	23	risk	risk	NOUN
dpc-4952	28	24	factor	factor	NOUN
dpc-4952	28	25	for	for	ADP
dpc-4952	28	26	melanoma	melanoma	NOUN
dpc-4952	28	27	.	.	PUNCT
dpc-4952	29	1	uvr	uvr	ADJ
dpc-4952	29	2	exposure	exposure	NOUN
dpc-4952	29	3	causes	cause	VERB
dpc-4952	29	4	oxidative	oxidative	ADJ
dpc-4952	29	5	stress	stress	NOUN
dpc-4952	29	6	,	,	PUNCT
dpc-4952	29	7	direct	direct	ADJ
dpc-4952	29	8	and	and	CCONJ
dpc-4952	29	9	indirect	indirect	ADJ
dpc-4952	29	10	damage	damage	NOUN
dpc-4952	29	11	to	to	ADP
dpc-4952	29	12	the	the	DET
dpc-4952	29	13	dna	dna	NOUN
dpc-4952	29	14	,	,	PUNCT
dpc-4952	29	15	and	and	CCONJ
dpc-4952	29	16	alteration	alteration	NOUN
dpc-4952	29	17	to	to	ADP
dpc-4952	29	18	dna	dna	PROPN
dpc-4952	29	19	repair	repair	NOUN
dpc-4952	29	20	proteins	protein	NOUN
dpc-4952	29	21	[	[	X
dpc-4952	29	22	1	1	NUM
dpc-4952	29	23	]	]	PUNCT
dpc-4952	29	24	.	.	PUNCT
dpc-4952	30	1	from	from	ADP
dpc-4952	30	2	a	a	DET
dpc-4952	30	3	biological	biological	ADJ
dpc-4952	30	4	and	and	CCONJ
dpc-4952	30	5	genetic	genetic	ADJ
dpc-4952	30	6	standpoint	standpoint	NOUN
dpc-4952	30	7	,	,	PUNCT
dpc-4952	30	8	melanomas	melanoma	NOUN
dpc-4952	30	9	arising	arise	VERB
dpc-4952	30	10	on	on	ADP
dpc-4952	30	11	chronically	chronically	ADV
dpc-4952	30	12	sun	sun	NOUN
dpc-4952	30	13	-	-	PUNCT
dpc-4952	30	14	damaged	damage	VERB
dpc-4952	30	15	skin	skin	NOUN
dpc-4952	30	16	(	(	PUNCT
dpc-4952	30	17	csds	csds	NOUN
dpc-4952	30	18	)	)	PUNCT
dpc-4952	30	19	demonstrate	demonstrate	VERB
dpc-4952	30	20	a	a	DET
dpc-4952	30	21	higher	high	ADJ
dpc-4952	30	22	mutational	mutational	ADJ
dpc-4952	30	23	burden	burden	NOUN
dpc-4952	30	24	[	[	X
dpc-4952	30	25	2	2	NUM
dpc-4952	30	26	]	]	PUNCT
dpc-4952	30	27	,	,	PUNCT
dpc-4952	30	28	including	include	VERB
dpc-4952	30	29	increased	increase	VERB
dpc-4952	30	30	frequency	frequency	NOUN
dpc-4952	30	31	of	of	ADP
dpc-4952	30	32	mutations	mutation	NOUN
dpc-4952	30	33	such	such	ADJ
dpc-4952	30	34	as	as	ADP
dpc-4952	30	35	braf	braf	NOUN
dpc-4952	30	36	-	-	PUNCT
dpc-4952	30	37	v600k	v600k	NOUN
dpc-4952	30	38	,	,	PUNCT
dpc-4952	30	39	nf1	nf1	NOUN
dpc-4952	30	40	,	,	PUNCT
dpc-4952	30	41	tp53	tp53	PROPN
dpc-4952	30	42	,	,	PUNCT
dpc-4952	30	43	and	and	CCONJ
dpc-4952	30	44	kit	kit	NOUN
dpc-4952	30	45	as	as	ADV
dpc-4952	30	46	well	well	ADV
dpc-4952	30	47	as	as	ADP
dpc-4952	30	48	 	 	SPACE
dpc-4952	30	49	increased	increase	VERB
dpc-4952	30	50	levels	level	NOUN
dpc-4952	30	51	of	of	ADP
dpc-4952	30	52	pd	pd	PROPN
dpc-4952	30	53	-	-	PROPN
dpc-4952	30	54	l.	l.	PROPN
dpc-4952	31	1	[	[	X
dpc-4952	31	2	3	3	NUM
dpc-4952	31	3	]	]	PUNCT
dpc-4952	31	4	studies	study	NOUN
dpc-4952	31	5	show	show	VERB
dpc-4952	31	6	that	that	SCONJ
dpc-4952	31	7	the	the	DET
dpc-4952	31	8	skin	skin	NOUN
dpc-4952	31	9	surrounding	surround	VERB
dpc-4952	31	10	a	a	DET
dpc-4952	31	11	melanoma	melanoma	NOUN
dpc-4952	31	12	on	on	ADP
dpc-4952	31	13	csds	csds	NOUN
dpc-4952	31	14	can	can	AUX
dpc-4952	31	15	harbor	harbor	VERB
dpc-4952	31	16	an	an	DET
dpc-4952	31	17	increased	increase	VERB
dpc-4952	31	18	mutational	mutational	ADJ
dpc-4952	31	19	load	load	NOUN
dpc-4952	31	20	(	(	PUNCT
dpc-4952	31	21	similar	similar	ADJ
dpc-4952	31	22	to	to	ADP
dpc-4952	31	23	that	that	PRON
dpc-4952	31	24	seen	see	VERB
dpc-4952	31	25	within	within	ADP
dpc-4952	31	26	the	the	DET
dpc-4952	31	27	melanoma	melanoma	NOUN
dpc-4952	31	28	)	)	PUNCT
dpc-4952	31	29	,	,	PUNCT
dpc-4952	31	30	suggesting	suggest	VERB
dpc-4952	31	31	that	that	SCONJ
dpc-4952	31	32	the	the	DET
dpc-4952	31	33	high	high	ADJ
dpc-4952	31	34	number	number	NOUN
dpc-4952	31	35	of	of	ADP
dpc-4952	31	36	oncogenic	oncogenic	ADJ
dpc-4952	31	37	mutations	mutation	NOUN
dpc-4952	31	38	within	within	ADP
dpc-4952	31	39	the	the	DET
dpc-4952	31	40	melanoma	melanoma	NOUN
dpc-4952	31	41	may	may	AUX
dpc-4952	31	42	be	be	AUX
dpc-4952	31	43	acquired	acquire	VERB
dpc-4952	31	44	at	at	ADP
dpc-4952	31	45	an	an	DET
dpc-4952	31	46	earlier	early	ADJ
dpc-4952	31	47	stage	stage	NOUN
dpc-4952	31	48	,	,	PUNCT
dpc-4952	31	49	and	and	CCONJ
dpc-4952	31	50	therefore	therefore	ADV
dpc-4952	31	51	additional	additional	ADJ
dpc-4952	31	52	mutations	mutation	NOUN
dpc-4952	31	53	may	may	AUX
dpc-4952	31	54	not	not	PART
dpc-4952	31	55	be	be	AUX
dpc-4952	31	56	required	require	VERB
dpc-4952	31	57	for	for	ADP
dpc-4952	31	58	its	its	PRON
dpc-4952	31	59	progression	progression	NOUN
dpc-4952	31	60	[	[	X
dpc-4952	31	61	3	3	NUM
dpc-4952	31	62	]	]	PUNCT
dpc-4952	31	63	.	.	PUNCT
dpc-4952	32	1	objectives	objective	NOUN
dpc-4952	32	2	to	to	PART
dpc-4952	32	3	identify	identify	VERB
dpc-4952	32	4	possible	possible	ADJ
dpc-4952	32	5	gene	gene	NOUN
dpc-4952	32	6	expression	expression	NOUN
dpc-4952	32	7	signatures	signature	NOUN
dpc-4952	32	8	in	in	ADP
dpc-4952	32	9	the	the	DET
dpc-4952	32	10	skin	skin	NOUN
dpc-4952	32	11	of	of	ADP
dpc-4952	32	12	patients	patient	NOUN
dpc-4952	32	13	with	with	ADP
dpc-4952	32	14	melanoma	melanoma	NOUN
dpc-4952	32	15	on	on	ADP
dpc-4952	32	16	csds	csds	NOUN
dpc-4952	32	17	that	that	PRON
dpc-4952	32	18	may	may	AUX
dpc-4952	32	19	contribute	contribute	VERB
dpc-4952	32	20	to	to	ADP
dpc-4952	32	21	melanomagenesis	melanomagenesis	NOUN
dpc-4952	32	22	.	.	PUNCT
dpc-4952	33	1	methods	method	NOUN
dpc-4952	33	2	this	this	DET
dpc-4952	33	3	observational	observational	ADJ
dpc-4952	33	4	experimental	experimental	ADJ
dpc-4952	33	5	research	research	NOUN
dpc-4952	33	6	study	study	NOUN
dpc-4952	33	7	included	include	VERB
dpc-4952	33	8	a	a	DET
dpc-4952	33	9	total	total	NOUN
dpc-4952	33	10	of	of	ADP
dpc-4952	33	11	10	10	NUM
dpc-4952	33	12	patients	patient	NOUN
dpc-4952	33	13	over	over	ADP
dpc-4952	33	14	18	18	NUM
dpc-4952	33	15	years	year	NOUN
dpc-4952	33	16	of	of	ADP
dpc-4952	33	17	age	age	NOUN
dpc-4952	33	18	with	with	ADP
dpc-4952	33	19	a	a	DET
dpc-4952	33	20	recent	recent	ADJ
dpc-4952	33	21	diagnosis	diagnosis	NOUN
dpc-4952	33	22	of	of	ADP
dpc-4952	33	23	melanoma	melanoma	NOUN
dpc-4952	33	24	on	on	ADP
dpc-4952	33	25	csds	csds	NOUN
dpc-4952	33	26	(	(	PUNCT
dpc-4952	33	27	i.e.	i.e.	X
dpc-4952	33	28	,	,	PUNCT
dpc-4952	33	29	diagnosis	diagnosis	NOUN
dpc-4952	33	30	no	no	DET
dpc-4952	33	31	more	more	ADJ
dpc-4952	33	32	than	than	ADP
dpc-4952	33	33	6	6	NUM
dpc-4952	33	34	months	month	NOUN
dpc-4952	33	35	before	before	ADP
dpc-4952	33	36	the	the	DET
dpc-4952	33	37	day	day	NOUN
dpc-4952	33	38	of	of	ADP
dpc-4952	33	39	enrollment	enrollment	NOUN
dpc-4952	33	40	)	)	PUNCT
dpc-4952	33	41	.	.	PUNCT
dpc-4952	34	1	csds	csds	PROPN
dpc-4952	34	2	was	be	AUX
dpc-4952	34	3	defined	define	VERB
dpc-4952	34	4	by	by	ADP
dpc-4952	34	5	the	the	DET
dpc-4952	34	6	clinical	clinical	ADJ
dpc-4952	34	7	presence	presence	NOUN
dpc-4952	34	8	of	of	ADP
dpc-4952	34	9	multiple	multiple	ADJ
dpc-4952	34	10	solar	solar	ADJ
dpc-4952	34	11	lentigines	lentigo	NOUN
dpc-4952	34	12	involving	involve	VERB
dpc-4952	34	13	at	at	ADV
dpc-4952	34	14	least	least	ADV
dpc-4952	34	15	three	three	NUM
dpc-4952	34	16	anatomical	anatomical	ADJ
dpc-4952	34	17	areas	area	NOUN
dpc-4952	34	18	,	,	PUNCT
dpc-4952	34	19	and	and	CCONJ
dpc-4952	34	20	pigmentary	pigmentary	ADJ
dpc-4952	34	21	changes	change	NOUN
dpc-4952	34	22	including	include	VERB
dpc-4952	34	23	dyschromia	dyschromia	NOUN
dpc-4952	34	24	,	,	PUNCT
dpc-4952	34	25	hypoand	hypoand	NOUN
dpc-4952	34	26	/	/	SYM
dpc-4952	34	27	or	or	CCONJ
dpc-4952	34	28	hyperpigmentation	hyperpigmentation	NOUN
dpc-4952	34	29	.	.	PUNCT
dpc-4952	35	1	for	for	ADP
dpc-4952	35	2	each	each	DET
dpc-4952	35	3	patient	patient	NOUN
dpc-4952	35	4	,	,	PUNCT
dpc-4952	35	5	two	two	NUM
dpc-4952	35	6	skin	skin	NOUN
dpc-4952	35	7	samples	sample	NOUN
dpc-4952	35	8	were	be	AUX
dpc-4952	35	9	obtained	obtain	VERB
dpc-4952	35	10	using	use	VERB
dpc-4952	35	11	a	a	DET
dpc-4952	35	12	2	2	NUM
dpc-4952	35	13	-	-	PUNCT
dpc-4952	35	14	mm	mm	NOUN
dpc-4952	35	15	punch	punch	NOUN
dpc-4952	35	16	biopsy	biopsy	NOUN
dpc-4952	35	17	,	,	PUNCT
dpc-4952	35	18	and	and	CCONJ
dpc-4952	35	19	specifically	specifically	ADV
dpc-4952	35	20	,	,	PUNCT
dpc-4952	35	21	one	one	NUM
dpc-4952	35	22	sample	sample	NOUN
dpc-4952	35	23	from	from	ADP
dpc-4952	35	24	csds	csds	NOUN
dpc-4952	35	25	within	within	ADP
dpc-4952	35	26	2	2	NUM
dpc-4952	35	27	cm	cm	NOUN
dpc-4952	35	28	of	of	ADP
dpc-4952	35	29	the	the	DET
dpc-4952	35	30	primary	primary	ADJ
dpc-4952	35	31	melanoma	melanoma	NOUN
dpc-4952	35	32	and	and	CCONJ
dpc-4952	35	33	a	a	DET
dpc-4952	35	34	second	second	ADJ
dpc-4952	35	35	sample	sample	NOUN
dpc-4952	35	36	from	from	ADP
dpc-4952	35	37	sun	sun	NOUN
dpc-4952	35	38	-	-	PUNCT
dpc-4952	35	39	protected	protect	VERB
dpc-4952	35	40	skin	skin	NOUN
dpc-4952	35	41	(	(	PUNCT
dpc-4952	35	42	i.e	i.e	X
dpc-4952	35	43	,	,	PUNCT
dpc-4952	35	44	retroauricular	retroauricular	ADJ
dpc-4952	35	45	,	,	PUNCT
dpc-4952	35	46	inner	inner	ADJ
dpc-4952	35	47	buttock	buttock	NOUN
dpc-4952	35	48	/	/	SYM
dpc-4952	35	49	gluteal	gluteal	NOUN
dpc-4952	35	50	fold	fold	NOUN
dpc-4952	35	51	)	)	PUNCT
dpc-4952	35	52	.	.	PUNCT
dpc-4952	36	1	each	each	DET
dpc-4952	36	2	skin	skin	NOUN
dpc-4952	36	3	sample	sample	NOUN
dpc-4952	36	4	was	be	AUX
dpc-4952	36	5	embedded	embed	VERB
dpc-4952	36	6	in	in	ADP
dpc-4952	36	7	rna	rna	NOUN
dpc-4952	36	8	-	-	PUNCT
dpc-4952	36	9	later	late	ADJ
dpc-4952	36	10	buffer	buffer	NOUN
dpc-4952	36	11	.	.	PUNCT
dpc-4952	37	1	rna	rna	NOUN
dpc-4952	37	2	was	be	AUX
dpc-4952	37	3	isolated	isolate	VERB
dpc-4952	37	4	utilizing	utilize	VERB
dpc-4952	37	5	the	the	DET
dpc-4952	37	6	rna	rna	NOUN
dpc-4952	37	7	extraction	extraction	NOUN
dpc-4952	37	8	kit	kit	NOUN
dpc-4952	37	9	(	(	PUNCT
dpc-4952	37	10	qiagen	qiagen	NOUN
dpc-4952	37	11	cat#74134	cat#74134	PROPN
dpc-4952	37	12	)	)	PUNCT
dpc-4952	37	13	and	and	CCONJ
dpc-4952	37	14	sent	send	VERB
dpc-4952	37	15	to	to	ADP
dpc-4952	37	16	the	the	DET
dpc-4952	37	17	sylvester	sylvest	ADJ
dpc-4952	37	18	onco	onco	NOUN
dpc-4952	37	19	-	-	PUNCT
dpc-4952	37	20	genomics	genomics	NOUN
dpc-4952	37	21	shared	share	VERB
dpc-4952	37	22	resource	resource	NOUN
dpc-4952	37	23	for	for	ADP
dpc-4952	37	24	library	library	ADJ
dpc-4952	37	25	preparation	preparation	NOUN
dpc-4952	37	26	and	and	CCONJ
dpc-4952	37	27	rna	rna	NOUN
dpc-4952	37	28	sequencing	sequencing	NOUN
dpc-4952	37	29	.	.	PUNCT
dpc-4952	37	30	 	 	SPACE
dpc-4952	38	1	this	this	DET
dpc-4952	38	2	study	study	NOUN
dpc-4952	38	3	was	be	AUX
dpc-4952	38	4	approved	approve	VERB
dpc-4952	38	5	by	by	ADP
dpc-4952	38	6	the	the	DET
dpc-4952	38	7	institutional	institutional	PROPN
dpc-4952	38	8	review	review	PROPN
dpc-4952	38	9	board	board	NOUN
dpc-4952	38	10	at	at	ADP
dpc-4952	38	11	the	the	DET
dpc-4952	38	12	university	university	PROPN
dpc-4952	38	13	of	of	ADP
dpc-4952	38	14	miami	miami	PROPN
dpc-4952	38	15	.	.	PUNCT
dpc-4952	39	1	the	the	DET
dpc-4952	39	2	rna	rna	NOUN
dpc-4952	39	3	-	-	PUNCT
dpc-4952	39	4	seq	seq	NOUN
dpc-4952	39	5	raw	raw	ADJ
dpc-4952	39	6	expression	expression	NOUN
dpc-4952	39	7	data	datum	NOUN
dpc-4952	39	8	was	be	AUX
dpc-4952	39	9	processed	process	VERB
dpc-4952	39	10	in	in	ADP
dpc-4952	39	11	the	the	DET
dpc-4952	39	12	r	r	NOUN
dpc-4952	39	13	-	-	PUNCT
dpc-4952	39	14	programming	programming	ADJ
dpc-4952	39	15	environment	environment	NOUN
dpc-4952	39	16	to	to	PART
dpc-4952	39	17	perform	perform	VERB
dpc-4952	39	18	statistical	statistical	ADJ
dpc-4952	39	19	calculations	calculation	NOUN
dpc-4952	39	20	and	and	CCONJ
dpc-4952	39	21	differential	differential	ADJ
dpc-4952	39	22	expression	expression	NOUN
dpc-4952	39	23	analysis	analysis	NOUN
dpc-4952	39	24	.	.	PUNCT
dpc-4952	40	1	to	to	PART
dpc-4952	40	2	evaluate	evaluate	VERB
dpc-4952	40	3	the	the	DET
dpc-4952	40	4	different	different	ADJ
dpc-4952	40	5	signaling	signal	VERB
dpc-4952	40	6	pathways	pathway	NOUN
dpc-4952	40	7	between	between	ADP
dpc-4952	40	8	csds	csds	NOUN
dpc-4952	40	9	and	and	CCONJ
dpc-4952	40	10	non	non	ADJ
dpc-4952	40	11	-	-	ADJ
dpc-4952	40	12	csds	csds	ADJ
dpc-4952	40	13	,	,	PUNCT
dpc-4952	40	14	the	the	DET
dpc-4952	40	15	gene	gene	NOUN
dpc-4952	40	16	set	set	VERB
dpc-4952	40	17	enrichment	enrichment	NOUN
dpc-4952	40	18	analysis	analysis	NOUN
dpc-4952	40	19	(	(	PUNCT
dpc-4952	40	20	gsea	gsea	NOUN
dpc-4952	40	21	)	)	PUNCT
dpc-4952	40	22	was	be	AUX
dpc-4952	40	23	conducted	conduct	VERB
dpc-4952	40	24	using	use	VERB
dpc-4952	40	25	the	the	DET
dpc-4952	40	26	cluster	cluster	NOUN
dpc-4952	40	27	profiler	profiler	NOUN
dpc-4952	40	28	r	r	NOUN
dpc-4952	40	29	-	-	NOUN
dpc-4952	40	30	package	package	NOUN
dpc-4952	40	31	[	[	X
dpc-4952	40	32	4	4	NUM
dpc-4952	40	33	]	]	PUNCT
dpc-4952	40	34	,	,	PUNCT
dpc-4952	40	35	and	and	CCONJ
dpc-4952	40	36	multirankseq	multirankseq	NOUN
dpc-4952	40	37	[	[	X
dpc-4952	40	38	5	5	NUM
dpc-4952	40	39	]	]	PUNCT
dpc-4952	40	40	was	be	AUX
dpc-4952	40	41	used	use	VERB
dpc-4952	40	42	to	to	PART
dpc-4952	40	43	identify	identify	VERB
dpc-4952	40	44	differentially	differentially	ADV
dpc-4952	40	45	expressed	express	VERB
dpc-4952	40	46	genes	gene	NOUN
dpc-4952	40	47	(	(	PUNCT
dpc-4952	40	48	deg	deg	PROPN
dpc-4952	40	49	)	)	PUNCT
dpc-4952	40	50	.	.	PUNCT
dpc-4952	41	1	gene	gene	NOUN
dpc-4952	41	2	ontology	ontology	NOUN
dpc-4952	41	3	and	and	CCONJ
dpc-4952	41	4	kyoto	kyoto	NOUN
dpc-4952	41	5	encyclopedia	encyclopedia	NOUN
dpc-4952	41	6	of	of	ADP
dpc-4952	41	7	genes	gene	NOUN
dpc-4952	41	8	and	and	CCONJ
dpc-4952	41	9	genomes	genome	NOUN
dpc-4952	41	10	pathway	pathway	NOUN
dpc-4952	41	11	(	(	PUNCT
dpc-4952	41	12	kegg	kegg	NOUN
dpc-4952	41	13	)	)	PUNCT
dpc-4952	41	14	enrichment	enrichment	NOUN
dpc-4952	41	15	analysis	analysis	NOUN
dpc-4952	41	16	were	be	AUX
dpc-4952	41	17	performed	perform	VERB
dpc-4952	41	18	to	to	PART
dpc-4952	41	19	understand	understand	VERB
dpc-4952	41	20	the	the	DET
dpc-4952	41	21	gene	gene	NOUN
dpc-4952	41	22	functional	functional	ADJ
dpc-4952	41	23	annotation	annotation	NOUN
dpc-4952	41	24	and	and	CCONJ
dpc-4952	41	25	functional	functional	ADJ
dpc-4952	41	26	enrichment	enrichment	NOUN
dpc-4952	41	27	for	for	ADP
dpc-4952	41	28	deg	deg	NOUN
dpc-4952	41	29	,	,	PUNCT
dpc-4952	41	30	respectively	respectively	ADV
dpc-4952	41	31	.	.	PUNCT
dpc-4952	42	1	false	false	ADJ
dpc-4952	42	2	discovery	discovery	NOUN
dpc-4952	42	3	rate	rate	NOUN
dpc-4952	42	4	p	p	X
dpc-4952	42	5	<	<	X
dpc-4952	42	6	0.05	0.05	NUM
dpc-4952	42	7	was	be	AUX
dpc-4952	42	8	set	set	VERB
dpc-4952	42	9	as	as	ADP
dpc-4952	42	10	the	the	DET
dpc-4952	42	11	significance	significance	NOUN
dpc-4952	42	12	criterion	criterion	NOUN
dpc-4952	42	13	.	.	PUNCT
dpc-4952	43	1	conclusions	conclusion	NOUN
dpc-4952	43	2	over	over	ADP
dpc-4952	43	3	the	the	DET
dpc-4952	43	4	course	course	NOUN
dpc-4952	43	5	of	of	ADP
dpc-4952	43	6	one	one	NUM
dpc-4952	43	7	year	year	NOUN
dpc-4952	43	8	,	,	PUNCT
dpc-4952	43	9	a	a	DET
dpc-4952	43	10	total	total	NOUN
dpc-4952	43	11	of	of	ADP
dpc-4952	43	12	10	10	NUM
dpc-4952	43	13	patients	patient	NOUN
dpc-4952	43	14	met	meet	VERB
dpc-4952	43	15	the	the	DET
dpc-4952	43	16	inclusion	inclusion	NOUN
dpc-4952	43	17	criteria	criterion	NOUN
dpc-4952	43	18	.	.	PUNCT
dpc-4952	44	1	due	due	ADP
dpc-4952	44	2	to	to	ADP
dpc-4952	44	3	the	the	DET
dpc-4952	44	4	small	small	ADJ
dpc-4952	44	5	skin	skin	NOUN
dpc-4952	44	6	sample	sample	NOUN
dpc-4952	44	7	size	size	NOUN
dpc-4952	44	8	(	(	PUNCT
dpc-4952	44	9	2	2	NUM
dpc-4952	44	10	mm	mm	NOUN
dpc-4952	44	11	punch	punch	NOUN
dpc-4952	44	12	)	)	PUNCT
dpc-4952	44	13	and	and	CCONJ
dpc-4952	44	14	fragile	fragile	ADJ
dpc-4952	44	15	nature	nature	NOUN
dpc-4952	44	16	of	of	ADP
dpc-4952	44	17	rna	rna	PROPN
dpc-4952	44	18	,	,	PUNCT
dpc-4952	44	19	which	which	PRON
dpc-4952	44	20	requires	require	VERB
dpc-4952	44	21	optimal	optimal	ADJ
dpc-4952	44	22	processing	processing	NOUN
dpc-4952	44	23	to	to	PART
dpc-4952	44	24	prevent	prevent	VERB
dpc-4952	44	25	degradation	degradation	NOUN
dpc-4952	44	26	,	,	PUNCT
dpc-4952	44	27	only	only	ADV
dpc-4952	44	28	the	the	DET
dpc-4952	44	29	skin	skin	NOUN
dpc-4952	44	30	samples	sample	NOUN
dpc-4952	44	31	from	from	ADP
dpc-4952	44	32	four	four	NUM
dpc-4952	44	33	patients	patient	NOUN
dpc-4952	44	34	met	meet	VERB
dpc-4952	44	35	the	the	DET
dpc-4952	44	36	necessary	necessary	ADJ
dpc-4952	44	37	quality	quality	NOUN
dpc-4952	44	38	standards	standard	NOUN
dpc-4952	44	39	for	for	ADP
dpc-4952	44	40	molecular	molecular	ADJ
dpc-4952	44	41	analyses	analysis	NOUN
dpc-4952	44	42	.	.	PUNCT
dpc-4952	45	1	the	the	DET
dpc-4952	45	2	patients	patient	NOUN
dpc-4952	45	3	’	'	PUNCT
dpc-4952	45	4	average	average	ADJ
dpc-4952	45	5	age	age	NOUN
dpc-4952	45	6	at	at	ADP
dpc-4952	45	7	diagnosis	diagnosis	NOUN
dpc-4952	45	8	was	be	AUX
dpc-4952	45	9	47.7	47.7	NUM
dpc-4952	45	10	years	year	NOUN
dpc-4952	45	11	;	;	PUNCT
dpc-4952	45	12	75	75	NUM
dpc-4952	45	13	%	%	NOUN
dpc-4952	45	14	(	(	PUNCT
dpc-4952	45	15	3/4	3/4	NUM
dpc-4952	45	16	)	)	PUNCT
dpc-4952	45	17	were	be	AUX
dpc-4952	45	18	females	female	NOUN
dpc-4952	45	19	.	.	PUNCT
dpc-4952	46	1	two	two	NUM
dpc-4952	46	2	patients	patient	NOUN
dpc-4952	46	3	had	have	VERB
dpc-4952	46	4	an	an	DET
dpc-4952	46	5	invasive	invasive	ADJ
dpc-4952	46	6	melanoma	melanoma	NOUN
dpc-4952	46	7	(	(	PUNCT
dpc-4952	46	8	average	average	ADJ
dpc-4952	46	9	thickness	thickness	NOUN
dpc-4952	46	10	0.65	0.65	NUM
dpc-4952	46	11	mm	mm	NOUN
dpc-4952	46	12	;	;	PUNCT
dpc-4952	46	13	range	range	NOUN
dpc-4952	46	14	0.3–1	0.3–1	PROPN
dpc-4952	46	15	mm	mm	PROPN
dpc-4952	46	16	)	)	PUNCT
dpc-4952	46	17	,	,	PUNCT
dpc-4952	46	18	and	and	CCONJ
dpc-4952	46	19	two	two	NUM
dpc-4952	46	20	,	,	PUNCT
dpc-4952	46	21	in	in	ADP
dpc-4952	46	22	-	-	PUNCT
dpc-4952	46	23	situ	situ	NOUN
dpc-4952	46	24	disease	disease	NOUN
dpc-4952	46	25	.	.	PUNCT
dpc-4952	47	1	superficial	superficial	ADJ
dpc-4952	47	2	spreading	spread	VERB
dpc-4952	47	3	melanoma	melanoma	NOUN
dpc-4952	47	4	(	(	PUNCT
dpc-4952	47	5	50	50	NUM
dpc-4952	47	6	%	%	NOUN
dpc-4952	47	7	)	)	PUNCT
dpc-4952	47	8	and	and	CCONJ
dpc-4952	47	9	lentigo	lentigo	ADJ
dpc-4952	47	10	maligna	maligna	PROPN
dpc-4952	47	11	(	(	PUNCT
dpc-4952	47	12	50	50	NUM
dpc-4952	47	13	%	%	NOUN
dpc-4952	47	14	)	)	PUNCT
dpc-4952	47	15	were	be	AUX
dpc-4952	47	16	the	the	DET
dpc-4952	47	17	histological	histological	ADJ
dpc-4952	47	18	subtypes	subtype	NOUN
dpc-4952	47	19	.	.	PUNCT
dpc-4952	48	1	tumors	tumor	NOUN
dpc-4952	48	2	were	be	AUX
dpc-4952	48	3	found	find	VERB
dpc-4952	48	4	on	on	ADP
dpc-4952	48	5	the	the	DET
dpc-4952	48	6	scalp	scalp	NOUN
dpc-4952	48	7	(	(	PUNCT
dpc-4952	48	8	50	50	NUM
dpc-4952	48	9	%	%	NOUN
dpc-4952	48	10	,	,	PUNCT
dpc-4952	48	11	n=2	n=2	ADV
dpc-4952	48	12	)	)	PUNCT
dpc-4952	48	13	,	,	PUNCT
dpc-4952	48	14	neck	neck	NOUN
dpc-4952	48	15	and	and	CCONJ
dpc-4952	48	16	chest	chest	NOUN
dpc-4952	48	17	.	.	PUNCT
dpc-4952	49	1	patients	patient	NOUN
dpc-4952	49	2	’	'	PUNCT
dpc-4952	49	3	average	average	ADJ
dpc-4952	49	4	body	body	NOUN
dpc-4952	49	5	mass	mass	NOUN
dpc-4952	49	6	index	index	NOUN
dpc-4952	49	7	was	be	AUX
dpc-4952	49	8	32.35	32.35	NUM
dpc-4952	49	9	(	(	PUNCT
dpc-4952	49	10	obesity	obesity	NOUN
dpc-4952	49	11	range	range	NOUN
dpc-4952	49	12	)	)	PUNCT
dpc-4952	49	13	(	(	PUNCT
dpc-4952	49	14	figure	figure	NOUN
dpc-4952	49	15	1	1	NUM
dpc-4952	49	16	)	)	PUNCT
dpc-4952	49	17	.	.	PUNCT
dpc-4952	50	1	to	to	PART
dpc-4952	50	2	screen	screen	VERB
dpc-4952	50	3	out	out	ADP
dpc-4952	50	4	the	the	DET
dpc-4952	50	5	hub	hub	NOUN
dpc-4952	50	6	csdsrelated	csdsrelate	VERB
dpc-4952	50	7	genes	gene	NOUN
dpc-4952	50	8	that	that	PRON
dpc-4952	50	9	may	may	AUX
dpc-4952	50	10	have	have	AUX
dpc-4952	50	11	contributed	contribute	VERB
dpc-4952	50	12	to	to	ADP
dpc-4952	50	13	the	the	DET
dpc-4952	50	14	development	development	NOUN
dpc-4952	50	15	of	of	ADP
dpc-4952	50	16	melanoma	melanoma	NOUN
dpc-4952	50	17	on	on	ADP
dpc-4952	50	18	csds	csds	NOUN
dpc-4952	50	19	,	,	PUNCT
dpc-4952	50	20	the	the	DET
dpc-4952	50	21	principal	principal	ADJ
dpc-4952	50	22	component	component	NOUN
dpc-4952	50	23	analysis	analysis	NOUN
dpc-4952	50	24	(	(	PUNCT
dpc-4952	50	25	pca	pca	NOUN
dpc-4952	50	26	)	)	PUNCT
dpc-4952	50	27	was	be	AUX
dpc-4952	50	28	performed	perform	VERB
dpc-4952	50	29	to	to	PART
dpc-4952	50	30	classify	classify	VERB
dpc-4952	50	31	the	the	DET
dpc-4952	50	32	relationship	relationship	NOUN
dpc-4952	50	33	between	between	ADP
dpc-4952	50	34	the	the	DET
dpc-4952	50	35	eight	eight	NUM
dpc-4952	50	36	samples	sample	NOUN
dpc-4952	50	37	.	.	PUNCT
dpc-4952	51	1	the	the	DET
dpc-4952	51	2	pca	pca	PROPN
dpc-4952	51	3	showed	show	VERB
dpc-4952	51	4	that	that	SCONJ
dpc-4952	51	5	three	three	NUM
dpc-4952	51	6	pairs	pair	NOUN
dpc-4952	51	7	of	of	ADP
dpc-4952	51	8	the	the	DET
dpc-4952	51	9	analyzed	analyze	VERB
dpc-4952	51	10	samples	sample	NOUN
dpc-4952	51	11	clustered	cluster	VERB
dpc-4952	51	12	together	together	ADV
dpc-4952	51	13	.	.	PUNCT
dpc-4952	52	1	significant	significant	ADJ
dpc-4952	52	2	differences	difference	NOUN
dpc-4952	52	3	were	be	AUX
dpc-4952	52	4	observed	observe	VERB
dpc-4952	52	5	between	between	ADP
dpc-4952	52	6	the	the	DET
dpc-4952	52	7	csds	csds	NOUN
dpc-4952	52	8	and	and	CCONJ
dpc-4952	52	9	non	non	ADJ
dpc-4952	52	10	-	-	ADJ
dpc-4952	52	11	csds	csds	ADJ
dpc-4952	52	12	samples	sample	NOUN
dpc-4952	52	13	(	(	PUNCT
dpc-4952	52	14	figure	figure	NOUN
dpc-4952	52	15	2	2	NUM
dpc-4952	52	16	)	)	PUNCT
dpc-4952	52	17	.	.	PUNCT
dpc-4952	53	1	applying	apply	VERB
dpc-4952	53	2	the	the	DET
dpc-4952	53	3	defined	define	VERB
dpc-4952	53	4	cutoff	cutoff	NOUN
dpc-4952	53	5	values	value	NOUN
dpc-4952	53	6	(	(	PUNCT
dpc-4952	53	7	log2foldchange	log2foldchange	PROPN
dpc-4952	53	8	>	>	PUNCT
dpc-4952	53	9	2.0	2.0	NUM
dpc-4952	53	10	and	and	CCONJ
dpc-4952	53	11	p.adj	p.adj	NOUN
dpc-4952	53	12	0.05	0.05	NUM
dpc-4952	53	13	)	)	PUNCT
dpc-4952	53	14	,	,	PUNCT
dpc-4952	53	15	six	six	NUM
dpc-4952	53	16	genes	gene	NOUN
dpc-4952	53	17	of	of	ADP
dpc-4952	53	18	interest	interest	NOUN
dpc-4952	53	19	were	be	AUX
dpc-4952	53	20	identified	identify	VERB
dpc-4952	53	21	and	and	CCONJ
dpc-4952	53	22	associated	associate	VERB
dpc-4952	53	23	with	with	ADP
dpc-4952	53	24	csds	csds	NOUN
dpc-4952	53	25	compared	compare	VERB
dpc-4952	53	26	to	to	ADP
dpc-4952	53	27	non	non	ADJ
dpc-4952	53	28	-	-	ADJ
dpc-4952	53	29	csds	csds	ADJ
dpc-4952	53	30	,	,	PUNCT
dpc-4952	53	31	including	include	VERB
dpc-4952	53	32	four	four	NUM
dpc-4952	53	33	upregulated	upregulated	ADJ
dpc-4952	53	34	(	(	PUNCT
dpc-4952	53	35	i.e.	i.e.	X
dpc-4952	53	36	,	,	PUNCT
dpc-4952	53	37	serpinb4	serpinb4	PROPN
dpc-4952	53	38	,	,	PUNCT
dpc-4952	53	39	rhcg	rhcg	NOUN
dpc-4952	53	40	,	,	PUNCT
dpc-4952	53	41	chst2	chst2	NOUN
dpc-4952	53	42	,	,	PUNCT
dpc-4952	53	43	krt16	krt16	NOUN
dpc-4952	53	44	)	)	PUNCT
dpc-4952	53	45	and	and	CCONJ
dpc-4952	53	46	one	one	NUM
dpc-4952	53	47	downregulated	downregulate	VERB
dpc-4952	53	48	gene	gene	NOUN
dpc-4952	53	49	on	on	ADP
dpc-4952	53	50	csds	csds	NOUN
dpc-4952	53	51	(	(	PUNCT
dpc-4952	53	52	i.e.	i.e.	X
dpc-4952	53	53	,	,	PUNCT
dpc-4952	53	54	cacna1h	cacna1h	PROPN
dpc-4952	53	55	)	)	PUNCT
dpc-4952	53	56	.	.	PUNCT
dpc-4952	54	1	to	to	PART
dpc-4952	54	2	investigate	investigate	VERB
dpc-4952	54	3	the	the	DET
dpc-4952	54	4	potential	potential	ADJ
dpc-4952	54	5	regulatory	regulatory	ADJ
dpc-4952	54	6	mechanism	mechanism	NOUN
dpc-4952	54	7	of	of	ADP
dpc-4952	54	8	the	the	DET
dpc-4952	54	9	degs	deg	NOUN
dpc-4952	54	10	in	in	ADP
dpc-4952	54	11	csds	csds	NOUN
dpc-4952	54	12	,	,	PUNCT
dpc-4952	54	13	we	we	PRON
dpc-4952	54	14	performed	perform	VERB
dpc-4952	54	15	gene	gene	NOUN
dpc-4952	54	16	ontology	ontology	NOUN
dpc-4952	54	17	and	and	CCONJ
dpc-4952	54	18	kegg	kegg	NOUN
dpc-4952	54	19	enrichment	enrichment	NOUN
dpc-4952	54	20	analysis	analysis	NOUN
dpc-4952	54	21	.	.	PUNCT
dpc-4952	55	1	the	the	DET
dpc-4952	55	2	biological	biological	ADJ
dpc-4952	55	3	functions	function	NOUN
dpc-4952	55	4	of	of	ADP
dpc-4952	55	5	these	these	DET
dpc-4952	55	6	skin	skin	NOUN
dpc-4952	55	7	samples	sample	NOUN
dpc-4952	55	8	were	be	AUX
dpc-4952	55	9	detected	detect	VERB
dpc-4952	55	10	by	by	ADP
dpc-4952	55	11	kegg	kegg	NOUN
dpc-4952	55	12	pathways	pathway	NOUN
dpc-4952	55	13	analysis	analysis	NOUN
dpc-4952	55	14	,	,	PUNCT
dpc-4952	55	15	which	which	PRON
dpc-4952	55	16	revealed	reveal	VERB
dpc-4952	55	17	that	that	SCONJ
dpc-4952	55	18	the	the	DET
dpc-4952	55	19	main	main	ADJ
dpc-4952	55	20	pathways	pathway	NOUN
dpc-4952	55	21	were	be	AUX
dpc-4952	55	22	il-17	il-17	ADV
dpc-4952	55	23	signaling	signal	VERB
dpc-4952	55	24	pathway	pathway	NOUN
dpc-4952	55	25	,	,	PUNCT
dpc-4952	55	26	abc	abc	PROPN
dpc-4952	55	27	transporters	transporter	NOUN
dpc-4952	55	28	,	,	PUNCT
dpc-4952	55	29	and	and	CCONJ
dpc-4952	55	30	oxidative	oxidative	ADJ
dpc-4952	55	31	phosphorylation	phosphorylation	NOUN
dpc-4952	55	32	(	(	PUNCT
dpc-4952	55	33	activated	activate	VERB
dpc-4952	55	34	pathways	pathway	NOUN
dpc-4952	55	35	)	)	PUNCT
dpc-4952	55	36	,	,	PUNCT
dpc-4952	55	37	proliferator	proliferator	NOUN
dpc-4952	55	38	-	-	PUNCT
dpc-4952	55	39	activated	activate	VERB
dpc-4952	55	40	receptor	receptor	NOUN
dpc-4952	55	41	(	(	PUNCT
dpc-4952	55	42	ppar	ppar	NOUN
dpc-4952	55	43	)	)	PUNCT
dpc-4952	55	44	as	as	ADV
dpc-4952	55	45	well	well	ADV
dpc-4952	55	46	as	as	ADP
dpc-4952	55	47	conclusions	conclusion	NOUN
dpc-4952	55	48	:	:	PUNCT
dpc-4952	55	49	csds	csds	NOUN
dpc-4952	55	50	can	can	AUX
dpc-4952	55	51	be	be	AUX
dpc-4952	55	52	an	an	DET
dpc-4952	55	53	adequate	adequate	ADJ
dpc-4952	55	54	milieu	milieu	NOUN
dpc-4952	55	55	for	for	ADP
dpc-4952	55	56	the	the	DET
dpc-4952	55	57	development	development	NOUN
dpc-4952	55	58	and	and	CCONJ
dpc-4952	55	59	progression	progression	NOUN
dpc-4952	55	60	of	of	ADP
dpc-4952	55	61	melanoma	melanoma	NOUN
dpc-4952	55	62	.	.	PUNCT
dpc-4952	56	1	csds	csds	NOUN
dpc-4952	56	2	reveals	reveal	VERB
dpc-4952	56	3	overexpression	overexpression	NOUN
dpc-4952	56	4	of	of	ADP
dpc-4952	56	5	pathways	pathway	NOUN
dpc-4952	56	6	involved	involve	VERB
dpc-4952	56	7	in	in	ADP
dpc-4952	56	8	inflammation	inflammation	NOUN
dpc-4952	56	9	,	,	PUNCT
dpc-4952	56	10	immune	immune	ADJ
dpc-4952	56	11	responses	response	NOUN
dpc-4952	56	12	,	,	PUNCT
dpc-4952	56	13	and	and	CCONJ
dpc-4952	56	14	oxidative	oxidative	ADJ
dpc-4952	56	15	phosphorylation	phosphorylation	NOUN
dpc-4952	56	16	,	,	PUNCT
dpc-4952	56	17	all	all	PRON
dpc-4952	56	18	of	of	ADP
dpc-4952	56	19	which	which	PRON
dpc-4952	56	20	may	may	AUX
dpc-4952	56	21	facilitate	facilitate	VERB
dpc-4952	56	22	interactions	interaction	NOUN
dpc-4952	56	23	between	between	ADP
dpc-4952	56	24	the	the	DET
dpc-4952	56	25	skin	skin	NOUN
dpc-4952	56	26	microenvironment	microenvironment	NOUN
dpc-4952	56	27	and	and	CCONJ
dpc-4952	56	28	melanocytes	melanocyte	NOUN
dpc-4952	56	29	/	/	SYM
dpc-4952	56	30	melanoma	melanoma	NOUN
dpc-4952	56	31	cells	cell	NOUN
dpc-4952	56	32	,	,	PUNCT
dpc-4952	56	33	predisposing	predispose	VERB
dpc-4952	56	34	to	to	ADP
dpc-4952	56	35	melanoma	melanoma	NOUN
dpc-4952	56	36	development	development	NOUN
dpc-4952	56	37	and	and	CCONJ
dpc-4952	56	38	progression	progression	NOUN
dpc-4952	56	39	.	.	PUNCT
dpc-4952	57	1	original	original	ADJ
dpc-4952	57	2	article	article	NOUN
dpc-4952	57	3	|	|	ADV
dpc-4952	57	4	dermatol	dermatol	ADJ
dpc-4952	57	5	pract	pract	NOUN
dpc-4952	57	6	concept	concept	NOUN
dpc-4952	57	7	.	.	PUNCT
dpc-4952	58	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	58	2	3	3	NUM
dpc-4952	58	3	endocytosis	endocytosis	NOUN
dpc-4952	58	4	and	and	CCONJ
dpc-4952	58	5	notch	notch	VERB
dpc-4952	58	6	signaling	signal	VERB
dpc-4952	58	7	pathway	pathway	NOUN
dpc-4952	58	8	(	(	PUNCT
dpc-4952	58	9	suppressed	suppress	VERB
dpc-4952	58	10	pathways	pathway	NOUN
dpc-4952	58	11	)	)	PUNCT
dpc-4952	58	12	.	.	PUNCT
dpc-4952	59	1	the	the	DET
dpc-4952	59	2	significantly	significantly	ADV
dpc-4952	59	3	enriched	enrich	VERB
dpc-4952	59	4	pathways	pathway	NOUN
dpc-4952	59	5	in	in	ADP
dpc-4952	59	6	the	the	DET
dpc-4952	59	7	two	two	NUM
dpc-4952	59	8	groups	group	NOUN
dpc-4952	59	9	were	be	AUX
dpc-4952	59	10	selected	select	VERB
dpc-4952	59	11	by	by	ADP
dpc-4952	59	12	adjusted	adjust	VERB
dpc-4952	59	13	p	p	NOUN
dpc-4952	59	14	-	-	PUNCT
dpc-4952	59	15	value	value	NOUN
dpc-4952	59	16	<	<	NOUN
dpc-4952	59	17	0.05	0.05	NUM
dpc-4952	59	18	.	.	PUNCT
dpc-4952	60	1	we	we	PRON
dpc-4952	60	2	found	find	VERB
dpc-4952	60	3	that	that	DET
dpc-4952	60	4	keratinization	keratinization	NOUN
dpc-4952	60	5	,	,	PUNCT
dpc-4952	60	6	epidermal	epidermal	ADJ
dpc-4952	60	7	cell	cell	NOUN
dpc-4952	60	8	differentiation	differentiation	NOUN
dpc-4952	60	9	,	,	PUNCT
dpc-4952	60	10	and	and	CCONJ
dpc-4952	60	11	keratinocyte	keratinocyte	NOUN
dpc-4952	60	12	differentiation	differentiation	NOUN
dpc-4952	60	13	genes	gene	NOUN
dpc-4952	60	14	were	be	AUX
dpc-4952	60	15	significantly	significantly	ADV
dpc-4952	60	16	enriched	enrich	VERB
dpc-4952	60	17	in	in	ADP
dpc-4952	60	18	the	the	DET
dpc-4952	60	19	csds	csds	NOUN
dpc-4952	60	20	group	group	NOUN
dpc-4952	60	21	(	(	PUNCT
dpc-4952	60	22	figure	figure	NOUN
dpc-4952	60	23	3	3	NUM
dpc-4952	60	24	)	)	PUNCT
dpc-4952	60	25	.	.	PUNCT
dpc-4952	61	1	melanoma	melanoma	NOUN
dpc-4952	61	2	development	development	NOUN
dpc-4952	61	3	and	and	CCONJ
dpc-4952	61	4	progression	progression	NOUN
dpc-4952	61	5	is	be	AUX
dpc-4952	61	6	a	a	DET
dpc-4952	61	7	complex	complex	ADJ
dpc-4952	61	8	and	and	CCONJ
dpc-4952	61	9	dynamic	dynamic	ADJ
dpc-4952	61	10	process	process	NOUN
dpc-4952	61	11	involving	involve	VERB
dpc-4952	61	12	melanoma	melanoma	NOUN
dpc-4952	61	13	cells	cell	NOUN
dpc-4952	61	14	and	and	CCONJ
dpc-4952	61	15	their	their	PRON
dpc-4952	61	16	interaction	interaction	NOUN
dpc-4952	61	17	with	with	ADP
dpc-4952	61	18	the	the	DET
dpc-4952	61	19	skin	skin	NOUN
dpc-4952	61	20	microenvironment	microenvironment	NOUN
dpc-4952	61	21	.	.	PUNCT
dpc-4952	62	1	evidence	evidence	NOUN
dpc-4952	62	2	demonstrates	demonstrate	VERB
dpc-4952	62	3	the	the	DET
dpc-4952	62	4	role	role	NOUN
dpc-4952	62	5	of	of	ADP
dpc-4952	62	6	the	the	DET
dpc-4952	62	7	microenvironment	microenvironment	NOUN
dpc-4952	62	8	in	in	ADP
dpc-4952	62	9	the	the	DET
dpc-4952	62	10	malignant	malignant	ADJ
dpc-4952	62	11	transformation	transformation	NOUN
dpc-4952	62	12	of	of	ADP
dpc-4952	62	13	melanocytes	melanocyte	NOUN
dpc-4952	62	14	,	,	PUNCT
dpc-4952	62	15	with	with	ADP
dpc-4952	62	16	some	some	DET
dpc-4952	62	17	niches	niche	NOUN
dpc-4952	62	18	(	(	PUNCT
dpc-4952	62	19	e.g.	e.g.	ADV
dpc-4952	62	20	,	,	PUNCT
dpc-4952	62	21	hair	hair	NOUN
dpc-4952	62	22	follicle	follicle	NOUN
dpc-4952	62	23	bulge	bulge	NOUN
dpc-4952	62	24	)	)	PUNCT
dpc-4952	62	25	protecting	protect	VERB
dpc-4952	62	26	against	against	ADP
dpc-4952	62	27	their	their	PRON
dpc-4952	62	28	malignant	malignant	ADJ
dpc-4952	62	29	transformation	transformation	NOUN
dpc-4952	62	30	and	and	CCONJ
dpc-4952	62	31	tumor	tumor	NOUN
dpc-4952	62	32	initiation	initiation	NOUN
dpc-4952	62	33	and	and	CCONJ
dpc-4952	62	34	other	other	ADJ
dpc-4952	62	35	interactions	interaction	NOUN
dpc-4952	62	36	supporting	support	VERB
dpc-4952	62	37	proliferation	proliferation	NOUN
dpc-4952	62	38	,	,	PUNCT
dpc-4952	62	39	angiogenesis	angiogenesis	NOUN
dpc-4952	62	40	,	,	PUNCT
dpc-4952	62	41	and	and	CCONJ
dpc-4952	62	42	metastasis	metastasis	NOUN
dpc-4952	62	43	.	.	PUNCT
dpc-4952	63	1	[	[	X
dpc-4952	63	2	6	6	NUM
dpc-4952	63	3	]	]	PUNCT
dpc-4952	63	4	.	.	PUNCT
dpc-4952	64	1	depending	depend	VERB
dpc-4952	64	2	on	on	ADP
dpc-4952	64	3	specific	specific	ADJ
dpc-4952	64	4	factors	factor	NOUN
dpc-4952	64	5	,	,	PUNCT
dpc-4952	64	6	the	the	DET
dpc-4952	64	7	skin	skin	NOUN
dpc-4952	64	8	can	can	AUX
dpc-4952	64	9	be	be	AUX
dpc-4952	64	10	a	a	DET
dpc-4952	64	11	favorable	favorable	ADJ
dpc-4952	64	12	microenvironment	microenvironment	NOUN
dpc-4952	64	13	for	for	ADP
dpc-4952	64	14	tumor	tumor	NOUN
dpc-4952	64	15	growth	growth	NOUN
dpc-4952	64	16	,	,	PUNCT
dpc-4952	64	17	hosting	host	VERB
dpc-4952	64	18	initial	initial	ADJ
dpc-4952	64	19	mutations	mutation	NOUN
dpc-4952	64	20	that	that	PRON
dpc-4952	64	21	may	may	AUX
dpc-4952	64	22	maintain	maintain	VERB
dpc-4952	64	23	their	their	PRON
dpc-4952	64	24	normal	normal	ADJ
dpc-4952	64	25	function	function	NOUN
dpc-4952	64	26	until	until	SCONJ
dpc-4952	64	27	further	further	ADJ
dpc-4952	64	28	mutations	mutation	NOUN
dpc-4952	64	29	lead	lead	VERB
dpc-4952	64	30	to	to	ADP
dpc-4952	64	31	melanoma	melanoma	NOUN
dpc-4952	64	32	formation	formation	NOUN
dpc-4952	64	33	.	.	PUNCT
dpc-4952	65	1	moreover	moreover	ADV
dpc-4952	65	2	,	,	PUNCT
dpc-4952	65	3	depending	depend	VERB
dpc-4952	65	4	on	on	ADP
dpc-4952	65	5	specific	specific	ADJ
dpc-4952	65	6	genetic	genetic	ADJ
dpc-4952	65	7	drivers	driver	NOUN
dpc-4952	65	8	as	as	ADV
dpc-4952	65	9	well	well	ADV
dpc-4952	65	10	as	as	ADP
dpc-4952	65	11	internal	internal	ADJ
dpc-4952	65	12	and/or	and/or	CCONJ
dpc-4952	65	13	external	external	ADJ
dpc-4952	65	14	stimuli	stimulus	NOUN
dpc-4952	65	15	(	(	PUNCT
dpc-4952	65	16	e.g.	e.g.	ADV
dpc-4952	65	17	,	,	PUNCT
dpc-4952	65	18	uvr	uvr	ADJ
dpc-4952	65	19	)	)	PUNCT
dpc-4952	65	20	,	,	PUNCT
dpc-4952	65	21	some	some	DET
dpc-4952	65	22	microenvironments	microenvironment	NOUN
dpc-4952	65	23	may	may	AUX
dpc-4952	65	24	or	or	CCONJ
dpc-4952	65	25	may	may	AUX
dpc-4952	65	26	not	not	PART
dpc-4952	65	27	be	be	AUX
dpc-4952	65	28	permissive	permissive	ADJ
dpc-4952	65	29	to	to	ADP
dpc-4952	65	30	melanocyte	melanocyte	NOUN
dpc-4952	65	31	transformation	transformation	NOUN
dpc-4952	65	32	.	.	PUNCT
dpc-4952	66	1	for	for	ADP
dpc-4952	66	2	figure	figure	NOUN
dpc-4952	66	3	1	1	NUM
dpc-4952	66	4	.	.	PUNCT
dpc-4952	66	5	primary	primary	ADJ
dpc-4952	66	6	cutaneous	cutaneous	ADJ
dpc-4952	66	7	melanoma	melanoma	NOUN
dpc-4952	66	8	of	of	ADP
dpc-4952	66	9	two	two	NUM
dpc-4952	66	10	patients	patient	NOUN
dpc-4952	66	11	.	.	PUNCT
dpc-4952	67	1	a	a	X
dpc-4952	67	2	-	-	PUNCT
dpc-4952	67	3	b	b	NOUN
dpc-4952	67	4	:	:	PUNCT
dpc-4952	67	5	clinical	clinical	ADJ
dpc-4952	67	6	and	and	CCONJ
dpc-4952	67	7	dermoscopic	dermoscopic	ADJ
dpc-4952	67	8	images	image	NOUN
dpc-4952	67	9	of	of	ADP
dpc-4952	67	10	lentigo	lentigo	ADJ
dpc-4952	67	11	maligna	maligna	NOUN
dpc-4952	67	12	on	on	ADP
dpc-4952	67	13	the	the	DET
dpc-4952	67	14	frontal	frontal	ADJ
dpc-4952	67	15	scalp	scalp	NOUN
dpc-4952	67	16	.	.	PUNCT
dpc-4952	68	1	c	c	X
dpc-4952	68	2	-	-	PUNCT
dpc-4952	68	3	d	d	NOUN
dpc-4952	68	4	:	:	PUNCT
dpc-4952	68	5	clinical	clinical	ADJ
dpc-4952	68	6	and	and	CCONJ
dpc-4952	68	7	dermoscopic	dermoscopic	ADJ
dpc-4952	68	8	images	image	NOUN
dpc-4952	68	9	of	of	ADP
dpc-4952	68	10	superficial	superficial	ADJ
dpc-4952	68	11	spreading	spread	VERB
dpc-4952	68	12	melanoma	melanoma	NOUN
dpc-4952	68	13	0.7	0.7	NUM
dpc-4952	68	14	mm	mm	NOUN
dpc-4952	68	15	on	on	ADP
dpc-4952	68	16	the	the	DET
dpc-4952	68	17	chest	chest	NOUN
dpc-4952	68	18	.	.	PUNCT
dpc-4952	69	1	figure	figure	NOUN
dpc-4952	69	2	2	2	NUM
dpc-4952	69	3	.	.	PUNCT
dpc-4952	69	4	principal	principal	ADJ
dpc-4952	69	5	component	component	NOUN
dpc-4952	69	6	analysis	analysis	NOUN
dpc-4952	69	7	of	of	ADP
dpc-4952	69	8	the	the	DET
dpc-4952	69	9	gene	gene	NOUN
dpc-4952	69	10	expression	expression	NOUN
dpc-4952	69	11	profiles	profile	NOUN
dpc-4952	69	12	of	of	ADP
dpc-4952	69	13	skin	skin	NOUN
dpc-4952	69	14	samples	sample	NOUN
dpc-4952	69	15	from	from	ADP
dpc-4952	69	16	chronically	chronically	ADV
dpc-4952	69	17	sun	sun	NOUN
dpc-4952	69	18	-	-	PUNCT
dpc-4952	69	19	damaged	damage	VERB
dpc-4952	69	20	skin	skin	NOUN
dpc-4952	69	21	(	(	PUNCT
dpc-4952	69	22	csds	csds	NOUN
dpc-4952	69	23	)	)	PUNCT
dpc-4952	69	24	and	and	CCONJ
dpc-4952	69	25	non	non	NOUN
dpc-4952	69	26	-	-	ADJ
dpc-4952	69	27	csds	csds	NOUN
dpc-4952	69	28	of	of	ADP
dpc-4952	69	29	patients	patient	NOUN
dpc-4952	69	30	with	with	ADP
dpc-4952	69	31	melanoma	melanoma	NOUN
dpc-4952	69	32	on	on	ADP
dpc-4952	69	33	csds	csds	NOUN
dpc-4952	69	34	.	.	PUNCT
dpc-4952	70	1	each	each	DET
dpc-4952	70	2	dot	dot	NOUN
dpc-4952	70	3	represents	represent	VERB
dpc-4952	70	4	an	an	DET
dpc-4952	70	5	rna	rna	NOUN
dpc-4952	70	6	-	-	PUNCT
dpc-4952	70	7	seq	seq	NOUN
dpc-4952	70	8	sample	sample	NOUN
dpc-4952	70	9	,	,	PUNCT
dpc-4952	70	10	with	with	ADP
dpc-4952	70	11	red	red	ADJ
dpc-4952	70	12	dots	dot	NOUN
dpc-4952	70	13	indicating	indicate	VERB
dpc-4952	70	14	csds	csds	NOUN
dpc-4952	70	15	and	and	CCONJ
dpc-4952	70	16	blue	blue	ADJ
dpc-4952	70	17	dots	dot	NOUN
dpc-4952	70	18	indicating	indicate	VERB
dpc-4952	70	19	non	non	ADJ
dpc-4952	70	20	-	-	ADJ
dpc-4952	70	21	csds	csds	ADJ
dpc-4952	70	22	.	.	PUNCT
dpc-4952	71	1	samples	sample	NOUN
dpc-4952	71	2	with	with	ADP
dpc-4952	71	3	similar	similar	ADJ
dpc-4952	71	4	gene	gene	NOUN
dpc-4952	71	5	expression	expression	NOUN
dpc-4952	71	6	profiles	profile	NOUN
dpc-4952	71	7	are	be	AUX
dpc-4952	71	8	clustered	cluster	VERB
dpc-4952	71	9	together	together	ADV
dpc-4952	71	10	.	.	PUNCT
dpc-4952	72	1	4	4	NUM
dpc-4952	72	2	original	original	ADJ
dpc-4952	72	3	article	article	NOUN
dpc-4952	72	4	|	|	ADV
dpc-4952	72	5	dermatol	dermatol	ADJ
dpc-4952	72	6	pract	pract	NOUN
dpc-4952	72	7	concept	concept	NOUN
dpc-4952	72	8	.	.	PUNCT
dpc-4952	73	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	73	2	receptors	receptor	NOUN
dpc-4952	73	3	[	[	X
dpc-4952	73	4	8	8	NUM
dpc-4952	73	5	]	]	PUNCT
dpc-4952	73	6	.	.	PUNCT
dpc-4952	74	1	on	on	ADP
dpc-4952	74	2	the	the	DET
dpc-4952	74	3	other	other	ADJ
dpc-4952	74	4	hand	hand	NOUN
dpc-4952	74	5	,	,	PUNCT
dpc-4952	74	6	the	the	DET
dpc-4952	74	7	notch	notch	ADJ
dpc-4952	74	8	signaling	signal	VERB
dpc-4952	74	9	pathway	pathway	NOUN
dpc-4952	74	10	,	,	PUNCT
dpc-4952	74	11	which	which	PRON
dpc-4952	74	12	plays	play	VERB
dpc-4952	74	13	a	a	DET
dpc-4952	74	14	role	role	NOUN
dpc-4952	74	15	in	in	ADP
dpc-4952	74	16	cell	cell	NOUN
dpc-4952	74	17	renewal	renewal	NOUN
dpc-4952	74	18	,	,	PUNCT
dpc-4952	74	19	differentiation	differentiation	NOUN
dpc-4952	74	20	,	,	PUNCT
dpc-4952	74	21	homeostasis	homeostasis	NOUN
dpc-4952	74	22	,	,	PUNCT
dpc-4952	74	23	and	and	CCONJ
dpc-4952	74	24	repair	repair	NOUN
dpc-4952	74	25	,	,	PUNCT
dpc-4952	74	26	was	be	AUX
dpc-4952	74	27	found	find	VERB
dpc-4952	74	28	to	to	PART
dpc-4952	74	29	be	be	AUX
dpc-4952	74	30	suppressed	suppress	VERB
dpc-4952	74	31	in	in	ADP
dpc-4952	74	32	csds	csds	NOUN
dpc-4952	74	33	,	,	PUNCT
dpc-4952	74	34	suggesting	suggest	VERB
dpc-4952	74	35	an	an	DET
dpc-4952	74	36	imbalance	imbalance	NOUN
dpc-4952	74	37	between	between	ADP
dpc-4952	74	38	pro	pro	ADJ
dpc-4952	74	39	-	-	ADJ
dpc-4952	74	40	inflammatory	inflammatory	ADJ
dpc-4952	74	41	and	and	CCONJ
dpc-4952	74	42	repair	repair	NOUN
dpc-4952	74	43	responses	response	NOUN
dpc-4952	74	44	.	.	PUNCT
dpc-4952	75	1	this	this	DET
dpc-4952	75	2	pathway	pathway	NOUN
dpc-4952	75	3	has	have	VERB
dpc-4952	75	4	anti	anti	ADJ
dpc-4952	75	5	-	-	ADJ
dpc-4952	75	6	apoptotic	apoptotic	ADJ
dpc-4952	75	7	functions	function	NOUN
dpc-4952	75	8	in	in	ADP
dpc-4952	75	9	keratinocytes	keratinocyte	NOUN
dpc-4952	75	10	uvb	uvb	ADJ
dpc-4952	75	11	-	-	NOUN
dpc-4952	75	12	response	response	NOUN
dpc-4952	75	13	through	through	ADP
dpc-4952	75	14	down	down	ADJ
dpc-4952	75	15	-	-	PUNCT
dpc-4952	75	16	modulation	modulation	NOUN
dpc-4952	75	17	of	of	ADP
dpc-4952	75	18	foxo3a	foxo3a	ADJ
dpc-4952	75	19	expression	expression	NOUN
dpc-4952	75	20	[	[	X
dpc-4952	75	21	10	10	NUM
dpc-4952	75	22	]	]	PUNCT
dpc-4952	75	23	.	.	PUNCT
dpc-4952	76	1	the	the	DET
dpc-4952	76	2	limitations	limitation	NOUN
dpc-4952	76	3	of	of	ADP
dpc-4952	76	4	our	our	PRON
dpc-4952	76	5	study	study	NOUN
dpc-4952	76	6	include	include	VERB
dpc-4952	76	7	the	the	DET
dpc-4952	76	8	limited	limited	ADJ
dpc-4952	76	9	number	number	NOUN
dpc-4952	76	10	of	of	ADP
dpc-4952	76	11	cases	case	NOUN
dpc-4952	76	12	and	and	CCONJ
dpc-4952	76	13	their	their	PRON
dpc-4952	76	14	heterogeneity	heterogeneity	NOUN
dpc-4952	76	15	.	.	PUNCT
dpc-4952	77	1	our	our	PRON
dpc-4952	77	2	findings	finding	NOUN
dpc-4952	77	3	support	support	VERB
dpc-4952	77	4	the	the	DET
dpc-4952	77	5	pivotal	pivotal	ADJ
dpc-4952	77	6	role	role	NOUN
dpc-4952	77	7	of	of	ADP
dpc-4952	77	8	the	the	DET
dpc-4952	77	9	skin	skin	NOUN
dpc-4952	77	10	microenvironment	microenvironment	NOUN
dpc-4952	77	11	,	,	PUNCT
dpc-4952	77	12	which	which	PRON
dpc-4952	77	13	under	under	ADP
dpc-4952	77	14	the	the	DET
dpc-4952	77	15	influence	influence	NOUN
dpc-4952	77	16	of	of	ADP
dpc-4952	77	17	uvr	uvr	NOUN
dpc-4952	77	18	facilitates	facilitate	VERB
dpc-4952	77	19	inflammatory	inflammatory	ADJ
dpc-4952	77	20	and	and	CCONJ
dpc-4952	77	21	immune	immune	ADJ
dpc-4952	77	22	responses	response	NOUN
dpc-4952	77	23	that	that	PRON
dpc-4952	77	24	can	can	AUX
dpc-4952	77	25	lead	lead	VERB
dpc-4952	77	26	to	to	ADP
dpc-4952	77	27	melanomagenesis	melanomagenesis	NOUN
dpc-4952	77	28	.	.	PUNCT
dpc-4952	78	1	csds	csds	NOUN
dpc-4952	78	2	reveals	reveal	VERB
dpc-4952	78	3	overexpression	overexpression	NOUN
dpc-4952	78	4	of	of	ADP
dpc-4952	78	5	pathways	pathway	NOUN
dpc-4952	78	6	involved	involve	VERB
dpc-4952	78	7	in	in	ADP
dpc-4952	78	8	inflammation	inflammation	NOUN
dpc-4952	78	9	,	,	PUNCT
dpc-4952	78	10	immune	immune	ADJ
dpc-4952	78	11	response	response	NOUN
dpc-4952	78	12	,	,	PUNCT
dpc-4952	78	13	and	and	CCONJ
dpc-4952	78	14	oxidative	oxidative	ADJ
dpc-4952	78	15	phosphorylation	phosphorylation	NOUN
dpc-4952	78	16	,	,	PUNCT
dpc-4952	78	17	which	which	PRON
dpc-4952	78	18	allow	allow	VERB
dpc-4952	78	19	interactions	interaction	NOUN
dpc-4952	78	20	between	between	ADP
dpc-4952	78	21	the	the	DET
dpc-4952	78	22	skin	skin	NOUN
dpc-4952	78	23	microenvironment	microenvironment	NOUN
dpc-4952	78	24	and	and	CCONJ
dpc-4952	78	25	melanocytes	melanocyte	NOUN
dpc-4952	78	26	/	/	SYM
dpc-4952	78	27	melanoma	melanoma	NOUN
dpc-4952	78	28	cells	cell	NOUN
dpc-4952	78	29	,	,	PUNCT
dpc-4952	78	30	predisposing	predispose	VERB
dpc-4952	78	31	to	to	ADP
dpc-4952	78	32	melanoma	melanoma	NOUN
dpc-4952	78	33	development	development	NOUN
dpc-4952	78	34	/	/	SYM
dpc-4952	78	35	progression	progression	NOUN
dpc-4952	78	36	.	.	PUNCT
dpc-4952	79	1	these	these	DET
dpc-4952	79	2	findings	finding	NOUN
dpc-4952	79	3	may	may	AUX
dpc-4952	79	4	serve	serve	VERB
dpc-4952	79	5	as	as	ADP
dpc-4952	79	6	a	a	DET
dpc-4952	79	7	valuable	valuable	ADJ
dpc-4952	79	8	baseline	baseline	NOUN
dpc-4952	79	9	for	for	ADP
dpc-4952	79	10	future	future	ADJ
dpc-4952	79	11	studies	study	NOUN
dpc-4952	79	12	and	and	CCONJ
dpc-4952	79	13	therapeutic	therapeutic	ADJ
dpc-4952	79	14	strategies	strategy	NOUN
dpc-4952	79	15	targeting	target	VERB
dpc-4952	79	16	the	the	DET
dpc-4952	79	17	microenvironmental	microenvironmental	ADJ
dpc-4952	79	18	factors	factor	NOUN
dpc-4952	79	19	that	that	PRON
dpc-4952	79	20	may	may	AUX
dpc-4952	79	21	contribute	contribute	VERB
dpc-4952	79	22	to	to	ADP
dpc-4952	79	23	melanoma	melanoma	NOUN
dpc-4952	79	24	progression	progression	NOUN
dpc-4952	79	25	.	.	PUNCT
dpc-4952	80	1	references	reference	NOUN
dpc-4952	80	2	1	1	NUM
dpc-4952	80	3	.	.	PUNCT
dpc-4952	80	4	pecorelli	pecorelli	PROPN
dpc-4952	81	1	a	a	PROPN
dpc-4952	81	2	,	,	PUNCT
dpc-4952	81	3	valacchi	valacchi	NOUN
dpc-4952	81	4	g.	g.	PROPN
dpc-4952	81	5	oxidative	oxidative	PROPN
dpc-4952	81	6	-	-	PUNCT
dpc-4952	81	7	stress	stress	NOUN
dpc-4952	81	8	-	-	PUNCT
dpc-4952	81	9	sensitive	sensitive	ADJ
dpc-4952	81	10	micrornas	microrna	NOUN
dpc-4952	81	11	in	in	ADP
dpc-4952	81	12	uv	uv	NOUN
dpc-4952	81	13	-	-	PUNCT
dpc-4952	81	14	promoted	promote	VERB
dpc-4952	81	15	development	development	NOUN
dpc-4952	81	16	of	of	ADP
dpc-4952	81	17	melanoma	melanoma	NOUN
dpc-4952	81	18	.	.	PUNCT
dpc-4952	82	1	cancers	cancer	NOUN
dpc-4952	82	2	(	(	PUNCT
dpc-4952	82	3	basel	basel	PROPN
dpc-4952	82	4	)	)	PUNCT
dpc-4952	82	5	.	.	PUNCT
dpc-4952	83	1	2022;14(13):3224	2022;14(13):3224	X
dpc-4952	83	2	.	.	X
dpc-4952	84	1	doi	doi	NOUN
dpc-4952	84	2	:	:	PUNCT
dpc-4952	84	3	10.3390	10.3390	NUM
dpc-4952	84	4	/	/	SYM
dpc-4952	84	5	cancers14133224	cancers14133224	PROPN
dpc-4952	84	6	.	.	PUNCT
dpc-4952	85	1	2	2	NUM
dpc-4952	85	2	.	.	X
dpc-4952	85	3	millán	millán	NOUN
dpc-4952	85	4	-	-	PUNCT
dpc-4952	85	5	esteban	esteban	PROPN
dpc-4952	85	6	d	d	PROPN
dpc-4952	85	7	,	,	PUNCT
dpc-4952	85	8	peña	peña	PROPN
dpc-4952	85	9	-	-	PUNCT
dpc-4952	85	10	chilet	chilet	PROPN
dpc-4952	85	11	m	m	PROPN
dpc-4952	85	12	,	,	PUNCT
dpc-4952	85	13	garcia	garcia	PROPN
dpc-4952	85	14	-	-	PUNCT
dpc-4952	85	15	casado	casado	PROPN
dpc-4952	85	16	z	z	PROPN
dpc-4952	85	17	,	,	PUNCT
dpc-4952	85	18	et	et	PROPN
dpc-4952	85	19	al	al	PROPN
dpc-4952	85	20	.	.	PUNCT
dpc-4952	85	21	mutational	mutational	ADJ
dpc-4952	85	22	characterization	characterization	NOUN
dpc-4952	85	23	of	of	ADP
dpc-4952	85	24	cutaneous	cutaneous	ADJ
dpc-4952	85	25	melanoma	melanoma	NOUN
dpc-4952	85	26	supports	support	VERB
dpc-4952	85	27	divergent	divergent	ADJ
dpc-4952	85	28	pathways	pathway	NOUN
dpc-4952	85	29	model	model	NOUN
dpc-4952	85	30	for	for	ADP
dpc-4952	85	31	melanoma	melanoma	NOUN
dpc-4952	85	32	development	development	NOUN
dpc-4952	85	33	.	.	PUNCT
dpc-4952	86	1	cancers	cancer	NOUN
dpc-4952	86	2	(	(	PUNCT
dpc-4952	86	3	basel	basel	PROPN
dpc-4952	86	4	)	)	PUNCT
dpc-4952	86	5	.	.	PUNCT
dpc-4952	87	1	2021;13(20):5219	2021;13(20):5219	X
dpc-4952	87	2	.	.	PUNCT
dpc-4952	87	3	doi	doi	NOUN
dpc-4952	87	4	:	:	PUNCT
dpc-4952	87	5	10.3390	10.3390	NUM
dpc-4952	87	6	/	/	SYM
dpc-4952	87	7	cancers13205219	cancers13205219	PROPN
dpc-4952	87	8	.	.	PUNCT
dpc-4952	88	1	example	example	NOUN
dpc-4952	88	2	,	,	PUNCT
dpc-4952	88	3	it	it	PRON
dpc-4952	88	4	is	be	AUX
dpc-4952	88	5	suggested	suggest	VERB
dpc-4952	88	6	that	that	SCONJ
dpc-4952	88	7	melanocyte	melanocyte	NOUN
dpc-4952	88	8	stem	stem	NOUN
dpc-4952	88	9	cells	cell	NOUN
dpc-4952	88	10	,	,	PUNCT
dpc-4952	88	11	which	which	PRON
dpc-4952	88	12	are	be	AUX
dpc-4952	88	13	usually	usually	ADV
dpc-4952	88	14	quiescent	quiescent	ADJ
dpc-4952	88	15	on	on	ADP
dpc-4952	88	16	the	the	DET
dpc-4952	88	17	hair	hair	NOUN
dpc-4952	88	18	follicle	follicle	NOUN
dpc-4952	88	19	bulge	bulge	NOUN
dpc-4952	88	20	,	,	PUNCT
dpc-4952	88	21	can	can	AUX
dpc-4952	88	22	only	only	ADV
dpc-4952	88	23	proliferate	proliferate	VERB
dpc-4952	88	24	and	and	CCONJ
dpc-4952	88	25	migrate	migrate	VERB
dpc-4952	88	26	to	to	ADP
dpc-4952	88	27	the	the	DET
dpc-4952	88	28	epidermis	epidermis	NOUN
dpc-4952	88	29	in	in	ADP
dpc-4952	88	30	response	response	NOUN
dpc-4952	88	31	to	to	ADP
dpc-4952	88	32	uvrinduced	uvrinduced	ADJ
dpc-4952	88	33	inflammation	inflammation	NOUN
dpc-4952	88	34	or	or	CCONJ
dpc-4952	88	35	by	by	ADP
dpc-4952	88	36	paracrine	paracrine	NOUN
dpc-4952	88	37	signals	signal	NOUN
dpc-4952	88	38	secreted	secrete	VERB
dpc-4952	88	39	by	by	ADP
dpc-4952	88	40	the	the	DET
dpc-4952	88	41	epidermal	epidermal	ADJ
dpc-4952	88	42	microenvironment	microenvironment	NOUN
dpc-4952	88	43	[	[	X
dpc-4952	88	44	7	7	NUM
dpc-4952	88	45	]	]	PUNCT
dpc-4952	88	46	.	.	PUNCT
dpc-4952	89	1	indeed	indeed	ADV
dpc-4952	89	2	,	,	PUNCT
dpc-4952	89	3	it	it	PRON
dpc-4952	89	4	is	be	AUX
dpc-4952	89	5	well	well	ADV
dpc-4952	89	6	known	know	VERB
dpc-4952	89	7	that	that	SCONJ
dpc-4952	89	8	uvr	uvr	NOUN
dpc-4952	89	9	promotes	promote	VERB
dpc-4952	89	10	skin	skin	NOUN
dpc-4952	89	11	inflammation	inflammation	NOUN
dpc-4952	89	12	,	,	PUNCT
dpc-4952	89	13	decreases	decrease	VERB
dpc-4952	89	14	immune	immune	ADJ
dpc-4952	89	15	surveillance	surveillance	NOUN
dpc-4952	89	16	,	,	PUNCT
dpc-4952	89	17	induces	induce	VERB
dpc-4952	89	18	cellular	cellular	ADJ
dpc-4952	89	19	stress	stress	NOUN
dpc-4952	89	20	(	(	PUNCT
dpc-4952	89	21	e.g.	e.g.	ADV
dpc-4952	89	22	,	,	PUNCT
dpc-4952	89	23	oxidative	oxidative	ADJ
dpc-4952	89	24	stress	stress	NOUN
dpc-4952	89	25	,	,	PUNCT
dpc-4952	89	26	accumulation	accumulation	NOUN
dpc-4952	89	27	of	of	ADP
dpc-4952	89	28	reactive	reactive	ADJ
dpc-4952	89	29	oxygen	oxygen	NOUN
dpc-4952	89	30	species	specie	NOUN
dpc-4952	89	31	)	)	PUNCT
dpc-4952	89	32	,	,	PUNCT
dpc-4952	89	33	and	and	CCONJ
dpc-4952	89	34	induces	induce	VERB
dpc-4952	89	35	changes	change	NOUN
dpc-4952	89	36	in	in	ADP
dpc-4952	89	37	gene	gene	NOUN
dpc-4952	89	38	expression	expression	NOUN
dpc-4952	89	39	and	and	CCONJ
dpc-4952	89	40	protein	protein	NOUN
dpc-4952	89	41	production	production	NOUN
dpc-4952	89	42	as	as	ADV
dpc-4952	89	43	well	well	ADV
dpc-4952	89	44	as	as	ADP
dpc-4952	89	45	nuclear	nuclear	ADJ
dpc-4952	89	46	and	and	CCONJ
dpc-4952	89	47	mitochondrial	mitochondrial	ADJ
dpc-4952	89	48	dna	dna	NOUN
dpc-4952	89	49	damage	damage	NOUN
dpc-4952	89	50	.	.	PUNCT
dpc-4952	90	1	in	in	ADP
dpc-4952	90	2	our	our	PRON
dpc-4952	90	3	study	study	NOUN
dpc-4952	90	4	,	,	PUNCT
dpc-4952	90	5	we	we	PRON
dpc-4952	90	6	found	find	VERB
dpc-4952	90	7	pathways	pathway	NOUN
dpc-4952	90	8	and	and	CCONJ
dpc-4952	90	9	genes	gene	NOUN
dpc-4952	90	10	that	that	PRON
dpc-4952	90	11	were	be	AUX
dpc-4952	90	12	overexpressed	overexpresse	VERB
dpc-4952	90	13	on	on	ADP
dpc-4952	90	14	csds	csds	NOUN
dpc-4952	90	15	but	but	CCONJ
dpc-4952	90	16	not	not	PART
dpc-4952	90	17	on	on	ADP
dpc-4952	90	18	sun	sun	NOUN
dpc-4952	90	19	-	-	PUNCT
dpc-4952	90	20	protected	protect	VERB
dpc-4952	90	21	skin	skin	NOUN
dpc-4952	90	22	of	of	ADP
dpc-4952	90	23	patients	patient	NOUN
dpc-4952	90	24	with	with	ADP
dpc-4952	90	25	melanoma	melanoma	NOUN
dpc-4952	90	26	on	on	ADP
dpc-4952	90	27	csds	csds	NOUN
dpc-4952	90	28	.	.	PUNCT
dpc-4952	91	1	interestingly	interestingly	ADV
dpc-4952	91	2	,	,	PUNCT
dpc-4952	91	3	these	these	DET
dpc-4952	91	4	overexpressed	overexpresse	VERB
dpc-4952	91	5	pathways	pathway	NOUN
dpc-4952	91	6	(	(	PUNCT
dpc-4952	91	7	i.e.	i.e.	X
dpc-4952	91	8	,	,	PUNCT
dpc-4952	91	9	il-17	il-17	NUM
dpc-4952	91	10	,	,	PUNCT
dpc-4952	91	11	abc	abc	PROPN
dpc-4952	91	12	transporters	transporter	NOUN
dpc-4952	91	13	,	,	PUNCT
dpc-4952	91	14	oxidative	oxidative	ADJ
dpc-4952	91	15	phosphorylation	phosphorylation	NOUN
dpc-4952	91	16	,	,	PUNCT
dpc-4952	91	17	ppar	ppar	NOUN
dpc-4952	91	18	signaling	signal	VERB
dpc-4952	91	19	pathway	pathway	NOUN
dpc-4952	91	20	)	)	PUNCT
dpc-4952	91	21	are	be	AUX
dpc-4952	91	22	all	all	PRON
dpc-4952	91	23	involved	involved	ADJ
dpc-4952	91	24	in	in	ADP
dpc-4952	91	25	inflammatory	inflammatory	ADJ
dpc-4952	91	26	conditions	condition	NOUN
dpc-4952	91	27	.	.	PUNCT
dpc-4952	92	1	for	for	ADP
dpc-4952	92	2	example	example	NOUN
dpc-4952	92	3	,	,	PUNCT
dpc-4952	92	4	the	the	DET
dpc-4952	92	5	oxidative	oxidative	ADJ
dpc-4952	92	6	phosphorylation	phosphorylation	NOUN
dpc-4952	92	7	pathway	pathway	NOUN
dpc-4952	92	8	,	,	PUNCT
dpc-4952	92	9	which	which	PRON
dpc-4952	92	10	is	be	AUX
dpc-4952	92	11	crucial	crucial	ADJ
dpc-4952	92	12	to	to	PART
dpc-4952	92	13	cell	cell	VERB
dpc-4952	92	14	energy	energy	NOUN
dpc-4952	92	15	homeostasis	homeostasis	NOUN
dpc-4952	92	16	and	and	CCONJ
dpc-4952	92	17	metabolic	metabolic	NOUN
dpc-4952	92	18	demands	demand	NOUN
dpc-4952	92	19	,	,	PUNCT
dpc-4952	92	20	may	may	AUX
dpc-4952	92	21	induce	induce	VERB
dpc-4952	92	22	a	a	DET
dpc-4952	92	23	hypoxic	hypoxic	ADJ
dpc-4952	92	24	,	,	PUNCT
dpc-4952	92	25	glucose	glucose	NOUN
dpc-4952	92	26	-	-	PUNCT
dpc-4952	92	27	deficient	deficient	ADJ
dpc-4952	92	28	,	,	PUNCT
dpc-4952	92	29	and	and	CCONJ
dpc-4952	92	30	acidic	acidic	ADJ
dpc-4952	92	31	tumor	tumor	NOUN
dpc-4952	92	32	microenvironment	microenvironment	NOUN
dpc-4952	92	33	that	that	PRON
dpc-4952	92	34	may	may	AUX
dpc-4952	92	35	inhibit	inhibit	VERB
dpc-4952	92	36	the	the	DET
dpc-4952	92	37	function	function	NOUN
dpc-4952	92	38	of	of	ADP
dpc-4952	92	39	immune	immune	ADJ
dpc-4952	92	40	cells	cell	NOUN
dpc-4952	92	41	[	[	X
dpc-4952	92	42	8	8	NUM
dpc-4952	92	43	]	]	PUNCT
dpc-4952	92	44	.	.	PUNCT
dpc-4952	93	1	furthermore	furthermore	ADV
dpc-4952	93	2	,	,	PUNCT
dpc-4952	93	3	the	the	DET
dpc-4952	93	4	il-17	il-17	NOUN
dpc-4952	93	5	and	and	CCONJ
dpc-4952	93	6	abc	abc	PROPN
dpc-4952	93	7	transporters	transporter	NOUN
dpc-4952	93	8	are	be	AUX
dpc-4952	93	9	involved	involve	VERB
dpc-4952	93	10	in	in	ADP
dpc-4952	93	11	immune	immune	ADJ
dpc-4952	93	12	cell	cell	NOUN
dpc-4952	93	13	responses	response	NOUN
dpc-4952	93	14	.	.	PUNCT
dpc-4952	94	1	specifically	specifically	ADV
dpc-4952	94	2	,	,	PUNCT
dpc-4952	94	3	the	the	DET
dpc-4952	94	4	il-17	il-17	NUM
dpc-4952	94	5	pathway	pathway	NOUN
dpc-4952	94	6	is	be	AUX
dpc-4952	94	7	involved	involve	VERB
dpc-4952	94	8	in	in	ADP
dpc-4952	94	9	the	the	DET
dpc-4952	94	10	activation	activation	NOUN
dpc-4952	94	11	and	and	CCONJ
dpc-4952	94	12	recruitment	recruitment	NOUN
dpc-4952	94	13	of	of	ADP
dpc-4952	94	14	immune	immune	ADJ
dpc-4952	94	15	cells	cell	NOUN
dpc-4952	94	16	to	to	ADP
dpc-4952	94	17	sites	site	NOUN
dpc-4952	94	18	of	of	ADP
dpc-4952	94	19	damaged	damage	VERB
dpc-4952	94	20	tissue	tissue	NOUN
dpc-4952	94	21	as	as	ADV
dpc-4952	94	22	well	well	ADV
dpc-4952	94	23	as	as	ADP
dpc-4952	94	24	in	in	ADP
dpc-4952	94	25	the	the	DET
dpc-4952	94	26	release	release	NOUN
dpc-4952	94	27	of	of	ADP
dpc-4952	94	28	pro	pro	ADJ
dpc-4952	94	29	-	-	ADJ
dpc-4952	94	30	inflammatory	inflammatory	ADJ
dpc-4952	94	31	cytokines	cytokine	NOUN
dpc-4952	94	32	.	.	PUNCT
dpc-4952	95	1	interestingly	interestingly	ADV
dpc-4952	95	2	,	,	PUNCT
dpc-4952	95	3	ppar	ppar	NOUN
dpc-4952	95	4	-	-	PUNCT
dpc-4952	95	5	γ	γ	NOUN
dpc-4952	95	6	exerts	exert	VERB
dpc-4952	95	7	inhibitory	inhibitory	ADJ
dpc-4952	95	8	effects	effect	NOUN
dpc-4952	95	9	on	on	ADP
dpc-4952	95	10	t	t	PROPN
dpc-4952	95	11	-	-	PUNCT
dpc-4952	95	12	helper	helper	NOUN
dpc-4952	95	13	cells	cell	NOUN
dpc-4952	95	14	,	,	PUNCT
dpc-4952	95	15	specifically	specifically	ADV
dpc-4952	95	16	in	in	ADP
dpc-4952	95	17	those	those	PRON
dpc-4952	95	18	secreting	secrete	VERB
dpc-4952	95	19	il-17	il-17	NOUN
dpc-4952	95	20	[	[	X
dpc-4952	95	21	9	9	NUM
dpc-4952	95	22	]	]	PUNCT
dpc-4952	95	23	.	.	PUNCT
dpc-4952	96	1	similarly	similarly	ADV
dpc-4952	96	2	,	,	PUNCT
dpc-4952	96	3	some	some	DET
dpc-4952	96	4	abc	abc	PROPN
dpc-4952	96	5	transporters	transporter	NOUN
dpc-4952	96	6	are	be	AUX
dpc-4952	96	7	implicated	implicate	VERB
dpc-4952	96	8	in	in	ADP
dpc-4952	96	9	immune	immune	ADJ
dpc-4952	96	10	responses	response	NOUN
dpc-4952	96	11	by	by	ADP
dpc-4952	96	12	regulating	regulate	VERB
dpc-4952	96	13	the	the	DET
dpc-4952	96	14	transport	transport	NOUN
dpc-4952	96	15	of	of	ADP
dpc-4952	96	16	lipids	lipid	NOUN
dpc-4952	96	17	and	and	CCONJ
dpc-4952	96	18	peptides	peptide	NOUN
dpc-4952	96	19	needed	need	VERB
dpc-4952	96	20	for	for	ADP
dpc-4952	96	21	the	the	DET
dpc-4952	96	22	function	function	NOUN
dpc-4952	96	23	of	of	ADP
dpc-4952	96	24	membrane	membrane	NOUN
dpc-4952	96	25	proteins	protein	NOUN
dpc-4952	96	26	,	,	PUNCT
dpc-4952	96	27	including	include	VERB
dpc-4952	96	28	innate	innate	ADJ
dpc-4952	96	29	immune	immune	ADJ
dpc-4952	96	30	system	system	NOUN
dpc-4952	96	31	figure	figure	NOUN
dpc-4952	96	32	3	3	NUM
dpc-4952	96	33	.	.	PUNCT
dpc-4952	97	1	the	the	DET
dpc-4952	97	2	network	network	NOUN
dpc-4952	97	3	diagram	diagram	NOUN
dpc-4952	97	4	illustrates	illustrate	VERB
dpc-4952	97	5	the	the	DET
dpc-4952	97	6	enriched	enriched	ADJ
dpc-4952	97	7	pathways	pathway	NOUN
dpc-4952	97	8	identified	identify	VERB
dpc-4952	97	9	between	between	ADP
dpc-4952	97	10	the	the	DET
dpc-4952	97	11	two	two	NUM
dpc-4952	97	12	groups	group	NOUN
dpc-4952	97	13	(	(	PUNCT
dpc-4952	97	14	csds	csds	NOUN
dpc-4952	97	15	and	and	CCONJ
dpc-4952	97	16	non	non	ADJ
dpc-4952	97	17	-	-	ADJ
dpc-4952	97	18	csds	csds	ADJ
dpc-4952	97	19	)	)	PUNCT
dpc-4952	97	20	based	base	VERB
dpc-4952	97	21	on	on	ADP
dpc-4952	97	22	an	an	DET
dpc-4952	97	23	adjusted	adjust	VERB
dpc-4952	97	24	p	p	NOUN
dpc-4952	97	25	-	-	PUNCT
dpc-4952	97	26	value	value	NOUN
dpc-4952	97	27	threshold	threshold	NOUN
dpc-4952	97	28	of	of	ADP
dpc-4952	97	29	<	<	X
dpc-4952	97	30	0.05	0.05	NUM
dpc-4952	97	31	.	.	PUNCT
dpc-4952	98	1	key	key	ADJ
dpc-4952	98	2	pathways	pathway	NOUN
dpc-4952	98	3	identified	identify	VERB
dpc-4952	98	4	include	include	VERB
dpc-4952	98	5	keratinization	keratinization	NOUN
dpc-4952	98	6	and	and	CCONJ
dpc-4952	98	7	epidermal	epidermal	ADJ
dpc-4952	98	8	cell	cell	NOUN
dpc-4952	98	9	differentiation	differentiation	NOUN
dpc-4952	98	10	.	.	PUNCT
dpc-4952	99	1	original	original	ADJ
dpc-4952	99	2	article	article	NOUN
dpc-4952	99	3	|	|	ADV
dpc-4952	99	4	dermatol	dermatol	ADJ
dpc-4952	99	5	pract	pract	NOUN
dpc-4952	99	6	concept	concept	NOUN
dpc-4952	99	7	.	.	PUNCT
dpc-4952	100	1	2025;15(2):4952	2025;15(2):4952	NUM
dpc-4952	100	2	5	5	NUM
dpc-4952	100	3	response	response	NOUN
dpc-4952	100	4	to	to	ADP
dpc-4952	100	5	uv	uv	NOUN
dpc-4952	100	6	exposure	exposure	NOUN
dpc-4952	100	7	.	.	PUNCT
dpc-4952	101	1	cell	cell	NOUN
dpc-4952	101	2	stem	stem	NOUN
dpc-4952	101	3	cell	cell	NOUN
dpc-4952	101	4	.	.	PUNCT
dpc-4952	102	1	2017;21(5):665–78.e6	2017;21(5):665–78.e6	NUM
dpc-4952	102	2	.	.	PUNCT
dpc-4952	103	1	doi	doi	NOUN
dpc-4952	103	2	:	:	PUNCT
dpc-4952	103	3	10.1016	10.1016	NUM
dpc-4952	103	4	/	/	SYM
dpc-4952	103	5	j.stem.2017.09.001	j.stem.2017.09.001	PROPN
dpc-4952	103	6	.	.	NOUN
dpc-4952	104	1	8	8	NUM
dpc-4952	104	2	.	.	X
dpc-4952	105	1	zhang	zhang	PROPN
dpc-4952	105	2	x	x	PROPN
dpc-4952	105	3	,	,	PUNCT
dpc-4952	105	4	tai	tai	PROPN
dpc-4952	105	5	z	z	PROPN
dpc-4952	105	6	,	,	PUNCT
dpc-4952	105	7	miao	miao	PROPN
dpc-4952	105	8	f	f	PROPN
dpc-4952	105	9	,	,	PUNCT
dpc-4952	105	10	et	et	PROPN
dpc-4952	105	11	al	al	PROPN
dpc-4952	105	12	.	.	PROPN
dpc-4952	105	13	metabolism	metabolism	NOUN
dpc-4952	105	14	heterogeneity	heterogeneity	NOUN
dpc-4952	105	15	in	in	ADP
dpc-4952	105	16	melanoma	melanoma	ADJ
dpc-4952	105	17	fuels	fuel	NOUN
dpc-4952	105	18	deactivation	deactivation	NOUN
dpc-4952	105	19	of	of	ADP
dpc-4952	105	20	immunotherapy	immunotherapy	NOUN
dpc-4952	105	21	:	:	PUNCT
dpc-4952	105	22	predict	predict	VERB
dpc-4952	105	23	before	before	ADP
dpc-4952	105	24	protect	protect	NOUN
dpc-4952	105	25	.	.	PUNCT
dpc-4952	106	1	front	front	ADJ
dpc-4952	106	2	oncol	oncol	ADJ
dpc-4952	106	3	.	.	PUNCT
dpc-4952	107	1	2022;12:1046102	2022;12:1046102	NUM
dpc-4952	107	2	.	.	X
dpc-4952	107	3	doi	doi	NOUN
dpc-4952	107	4	:	:	PUNCT
dpc-4952	107	5	10.3389/	10.3389/	NUM
dpc-4952	107	6	fonc.2022.1046102	fonc.2022.1046102	NOUN
dpc-4952	107	7	.	.	PUNCT
dpc-4952	108	1	9	9	NUM
dpc-4952	108	2	.	.	PUNCT
dpc-4952	108	3	klotz	klotz	PROPN
dpc-4952	108	4	l	l	PROPN
dpc-4952	108	5	,	,	PUNCT
dpc-4952	108	6	burgdorf	burgdorf	PROPN
dpc-4952	108	7	s	s	PROPN
dpc-4952	108	8	,	,	PUNCT
dpc-4952	108	9	dani	dani	PROPN
dpc-4952	108	10	i	i	PROPN
dpc-4952	108	11	,	,	PUNCT
dpc-4952	108	12	et	et	PROPN
dpc-4952	108	13	al	al	PROPN
dpc-4952	108	14	.	.	PUNCT
dpc-4952	109	1	the	the	DET
dpc-4952	109	2	nuclear	nuclear	ADJ
dpc-4952	109	3	receptor	receptor	NOUN
dpc-4952	109	4	ppar	ppar	NOUN
dpc-4952	109	5	gamma	gamma	NOUN
dpc-4952	109	6	selectively	selectively	ADV
dpc-4952	109	7	inhibits	inhibit	VERB
dpc-4952	109	8	th17	th17	PROPN
dpc-4952	109	9	differentiation	differentiation	NOUN
dpc-4952	109	10	in	in	ADP
dpc-4952	109	11	a	a	DET
dpc-4952	109	12	t	t	NOUN
dpc-4952	109	13	cellintrinsic	cellintrinsic	ADJ
dpc-4952	109	14	fashion	fashion	NOUN
dpc-4952	109	15	and	and	CCONJ
dpc-4952	109	16	suppresses	suppress	VERB
dpc-4952	109	17	cns	cns	NOUN
dpc-4952	109	18	autoimmunity	autoimmunity	NOUN
dpc-4952	109	19	.	.	PUNCT
dpc-4952	110	1	j	j	PROPN
dpc-4952	110	2	exp	exp	NOUN
dpc-4952	110	3	med	me	VERB
dpc-4952	110	4	.	.	PUNCT
dpc-4952	111	1	2009;206(10):2079–89	2009;206(10):2079–89	X
dpc-4952	111	2	.	.	X
dpc-4952	111	3	doi	doi	NOUN
dpc-4952	111	4	:	:	PUNCT
dpc-4952	111	5	10.1084	10.1084	NUM
dpc-4952	111	6	/	/	SYM
dpc-4952	111	7	jem.2008	jem.2008	PRON
dpc-4952	111	8	2771	2771	NUM
dpc-4952	111	9	.	.	PUNCT
dpc-4952	112	1	10	10	NUM
dpc-4952	112	2	.	.	X
dpc-4952	112	3	mandinova	mandinova	VERB
dpc-4952	112	4	a	a	DET
dpc-4952	112	5	,	,	PUNCT
dpc-4952	112	6	lefort	lefort	PROPN
dpc-4952	112	7	k	k	PROPN
dpc-4952	112	8	,	,	PUNCT
dpc-4952	113	1	tommasi	tommasi	PROPN
dpc-4952	113	2	di	di	PROPN
dpc-4952	113	3	vignano	vignano	PROPN
dpc-4952	113	4	a	a	PRON
dpc-4952	113	5	,	,	PUNCT
dpc-4952	113	6	et	et	PROPN
dpc-4952	113	7	al	al	PROPN
dpc-4952	113	8	.	.	PUNCT
dpc-4952	114	1	the	the	DET
dpc-4952	114	2	foxo3a	foxo3a	ADJ
dpc-4952	114	3	gene	gene	NOUN
dpc-4952	114	4	is	be	AUX
dpc-4952	114	5	a	a	DET
dpc-4952	114	6	key	key	ADJ
dpc-4952	114	7	negative	negative	ADJ
dpc-4952	114	8	target	target	NOUN
dpc-4952	114	9	of	of	ADP
dpc-4952	114	10	canonical	canonical	ADJ
dpc-4952	114	11	notch	notch	NOUN
dpc-4952	114	12	signalling	signal	VERB
dpc-4952	114	13	in	in	ADP
dpc-4952	114	14	the	the	DET
dpc-4952	114	15	keratinocyte	keratinocyte	NOUN
dpc-4952	114	16	uvb	uvb	ADJ
dpc-4952	114	17	response	response	NOUN
dpc-4952	114	18	.	.	PUNCT
dpc-4952	115	1	embo	embo	PROPN
dpc-4952	115	2	j.	j.	PROPN
dpc-4952	115	3	2008;27(8	2008;27(8	PROPN
dpc-4952	115	4	):	):	PUNCT
dpc-4952	115	5	1243–1254	1243–1254	NUM
dpc-4952	115	6	.	.	PUNCT
dpc-4952	116	1	doi	doi	NOUN
dpc-4952	116	2	:	:	PUNCT
dpc-4952	116	3	10.1038	10.1038	NUM
dpc-4952	116	4	/	/	SYM
dpc-4952	116	5	emboj.2008.45	emboj.2008.45	NOUN
dpc-4952	116	6	.	.	PUNCT
dpc-4952	117	1	3	3	X
dpc-4952	117	2	.	.	X
dpc-4952	117	3	sanna	sanna	PROPN
dpc-4952	117	4	a	a	PRON
dpc-4952	117	5	,	,	PUNCT
dpc-4952	117	6	harbst	harbst	PROPN
dpc-4952	117	7	k	k	PROPN
dpc-4952	117	8	,	,	PUNCT
dpc-4952	117	9	johansson	johansson	PROPN
dpc-4952	117	10	i	i	PROPN
dpc-4952	117	11	,	,	PUNCT
dpc-4952	117	12	et	et	PROPN
dpc-4952	117	13	al	al	PROPN
dpc-4952	117	14	.	.	PROPN
dpc-4952	118	1	tumor	tumor	PROPN
dpc-4952	118	2	genetic	genetic	ADJ
dpc-4952	118	3	heterogeneity	heterogeneity	NOUN
dpc-4952	118	4	analysis	analysis	NOUN
dpc-4952	118	5	of	of	ADP
dpc-4952	118	6	chronic	chronic	ADJ
dpc-4952	118	7	sun	sun	NOUN
dpc-4952	118	8	-	-	PUNCT
dpc-4952	118	9	damaged	damage	VERB
dpc-4952	118	10	melanoma	melanoma	NOUN
dpc-4952	118	11	.	.	PUNCT
dpc-4952	119	1	pigment	pigment	ADJ
dpc-4952	119	2	cell	cell	NOUN
dpc-4952	119	3	melanoma	melanoma	NOUN
dpc-4952	119	4	res	re	NOUN
dpc-4952	119	5	.	.	PUNCT
dpc-4952	120	1	2020;33(3):480–89	2020;33(3):480–89	NUM
dpc-4952	120	2	.	.	PUNCT
dpc-4952	121	1	doi	doi	NOUN
dpc-4952	121	2	:	:	PUNCT
dpc-4952	121	3	10.1111	10.1111	NUM
dpc-4952	121	4	/	/	SYM
dpc-4952	121	5	pcmr.12851	pcmr.12851	PROPN
dpc-4952	121	6	.	.	NOUN
dpc-4952	122	1	4	4	NUM
dpc-4952	122	2	.	.	X
dpc-4952	122	3	wu	wu	PROPN
dpc-4952	122	4	t	t	PROPN
dpc-4952	122	5	,	,	PUNCT
dpc-4952	122	6	hu	hu	PROPN
dpc-4952	123	1	e	e	PROPN
dpc-4952	123	2	,	,	PUNCT
dpc-4952	123	3	xu	xu	PROPN
dpc-4952	123	4	s	s	PROPN
dpc-4952	123	5	,	,	PUNCT
dpc-4952	123	6	et	et	PROPN
dpc-4952	123	7	al	al	PROPN
dpc-4952	123	8	.	.	PROPN
dpc-4952	123	9	clusterprofiler	clusterprofiler	PROPN
dpc-4952	123	10	4.0	4.0	NUM
dpc-4952	123	11	:	:	PUNCT
dpc-4952	123	12	a	a	DET
dpc-4952	123	13	universal	universal	ADJ
dpc-4952	123	14	enrichment	enrichment	NOUN
dpc-4952	123	15	tool	tool	NOUN
dpc-4952	123	16	for	for	ADP
dpc-4952	123	17	interpreting	interpret	VERB
dpc-4952	123	18	omics	omic	NOUN
dpc-4952	123	19	data	datum	NOUN
dpc-4952	123	20	.	.	PUNCT
dpc-4952	124	1	innovation	innovation	NOUN
dpc-4952	124	2	(	(	PUNCT
dpc-4952	124	3	camb	camb	PROPN
dpc-4952	124	4	)	)	PUNCT
dpc-4952	124	5	.	.	PUNCT
dpc-4952	125	1	2021;2(3):100141	2021;2(3):100141	X
dpc-4952	125	2	.	.	X
dpc-4952	125	3	doi	doi	NOUN
dpc-4952	125	4	:	:	PUNCT
dpc-4952	125	5	10.1016	10.1016	NUM
dpc-4952	125	6	/	/	SYM
dpc-4952	125	7	j.xinn.2021.100141	j.xinn.2021.100141	NOUN
dpc-4952	125	8	.	.	PUNCT
dpc-4952	126	1	5	5	X
dpc-4952	126	2	.	.	X
dpc-4952	126	3	guo	guo	PROPN
dpc-4952	126	4	y	y	PROPN
dpc-4952	126	5	,	,	PUNCT
dpc-4952	126	6	zhao	zhao	PROPN
dpc-4952	126	7	s	s	PROPN
dpc-4952	126	8	,	,	PUNCT
dpc-4952	126	9	ye	ye	PRON
dpc-4952	126	10	f	f	NOUN
dpc-4952	126	11	,	,	PUNCT
dpc-4952	126	12	sheng	sheng	PROPN
dpc-4952	126	13	q	q	PROPN
dpc-4952	126	14	,	,	PUNCT
dpc-4952	126	15	shyr	shyr	PROPN
dpc-4952	126	16	y.	y.	PROPN
dpc-4952	126	17	multirankseq	multirankseq	PROPN
dpc-4952	126	18	:	:	PUNCT
dpc-4952	126	19	multiperspective	multiperspective	ADJ
dpc-4952	126	20	approach	approach	NOUN
dpc-4952	126	21	for	for	ADP
dpc-4952	126	22	rnaseq	rnaseq	NOUN
dpc-4952	126	23	differential	differential	NOUN
dpc-4952	126	24	expression	expression	NOUN
dpc-4952	126	25	analysis	analysis	NOUN
dpc-4952	126	26	and	and	CCONJ
dpc-4952	126	27	quality	quality	NOUN
dpc-4952	126	28	control	control	NOUN
dpc-4952	126	29	.	.	PUNCT
dpc-4952	126	30	biomed	biome	VERB
dpc-4952	126	31	res	re	NOUN
dpc-4952	126	32	int	int	NOUN
dpc-4952	126	33	.	.	PUNCT
dpc-4952	127	1	2014;2014:248090	2014;2014:248090	X
dpc-4952	127	2	.	.	PUNCT
dpc-4952	128	1	doi	doi	NOUN
dpc-4952	128	2	:	:	PUNCT
dpc-4952	128	3	10.1155/2014/248090	10.1155/2014/248090	NUM
dpc-4952	128	4	.	.	NOUN
dpc-4952	128	5	6	6	NUM
dpc-4952	128	6	.	.	X
dpc-4952	129	1	chhabra	chhabra	PROPN
dpc-4952	129	2	y	y	PROPN
dpc-4952	129	3	,	,	PUNCT
dpc-4952	129	4	weeraratna	weeraratna	VERB
dpc-4952	129	5	at	at	ADP
dpc-4952	129	6	.	.	PUNCT
dpc-4952	130	1	fibroblasts	fibroblast	NOUN
dpc-4952	130	2	in	in	ADP
dpc-4952	130	3	cancer	cancer	NOUN
dpc-4952	130	4	:	:	PUNCT
dpc-4952	130	5	unity	unity	NOUN
dpc-4952	130	6	in	in	ADP
dpc-4952	130	7	heterogeneity	heterogeneity	NOUN
dpc-4952	130	8	.	.	PUNCT
dpc-4952	131	1	cell	cell	NOUN
dpc-4952	131	2	.	.	PUNCT
dpc-4952	132	1	2023;186(8):1580–609	2023;186(8):1580–609	NOUN
dpc-4952	132	2	.	.	PUNCT
dpc-4952	133	1	doi	doi	NOUN
dpc-4952	133	2	:	:	PUNCT
dpc-4952	133	3	10.1016	10.1016	NUM
dpc-4952	133	4	/	/	SYM
dpc-4952	133	5	j.cell	j.cell	PROPN
dpc-4952	133	6	.2023.03.016	.2023.03.016	PROPN
dpc-4952	133	7	.	.	PUNCT
dpc-4952	134	1	7	7	X
dpc-4952	134	2	.	.	X
dpc-4952	134	3	moon	moon	PROPN
dpc-4952	134	4	h	h	PROPN
dpc-4952	134	5	,	,	PUNCT
dpc-4952	134	6	donahue	donahue	PROPN
dpc-4952	134	7	lr	lr	PROPN
dpc-4952	134	8	,	,	PUNCT
dpc-4952	134	9	choi	choi	NOUN
dpc-4952	134	10	e	e	PROPN
dpc-4952	134	11	,	,	PUNCT
dpc-4952	134	12	et	et	PROPN
dpc-4952	134	13	al	al	PROPN
dpc-4952	134	14	.	.	PUNCT
dpc-4952	134	15	melanocyte	melanocyte	NOUN
dpc-4952	134	16	stem	stem	NOUN
dpc-4952	134	17	cell	cell	NOUN
dpc-4952	134	18	activation	activation	NOUN
dpc-4952	134	19	and	and	CCONJ
dpc-4952	134	20	translocation	translocation	NOUN
dpc-4952	134	21	initiate	initiate	VERB
dpc-4952	134	22	cutaneous	cutaneous	ADJ
dpc-4952	134	23	melanoma	melanoma	NOUN
dpc-4952	134	24	in	in	ADP