id	sid	tid	token	lemma	pos
dpc-5172	1	1	dermatology	dermatology	NOUN
dpc-5172	1	2	:	:	PUNCT
dpc-5172	1	3	practical	practical	ADJ
dpc-5172	1	4	and	and	CCONJ
dpc-5172	1	5	conceptual	conceptual	ADJ
dpc-5172	1	6	review	review	NOUN
dpc-5172	1	7	|	|	ADV
dpc-5172	1	8	dermatol	dermatol	ADJ
dpc-5172	1	9	pract	pract	NOUN
dpc-5172	1	10	concept	concept	NOUN
dpc-5172	1	11	.	.	PUNCT
dpc-5172	2	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	2	2	1	1	NUM
dpc-5172	2	3	tretinoin	tretinoin	NOUN
dpc-5172	2	4	for	for	ADP
dpc-5172	2	5	photodamaged	photodamage	VERB
dpc-5172	2	6	facial	facial	ADJ
dpc-5172	2	7	skin	skin	NOUN
dpc-5172	2	8	:	:	PUNCT
dpc-5172	2	9	systematic	systematic	ADJ
dpc-5172	2	10	review	review	NOUN
dpc-5172	2	11	and	and	CCONJ
dpc-5172	2	12	meta	meta	NOUN
dpc-5172	2	13	-	-	PUNCT
dpc-5172	2	14	analysis	analysis	NOUN
dpc-5172	2	15	of	of	ADP
dpc-5172	2	16	randomized	randomized	ADJ
dpc-5172	2	17	controlled	control	VERB
dpc-5172	2	18	trials	trial	NOUN
dpc-5172	2	19	hsin	hsin	PROPN
dpc-5172	2	20	-	-	PUNCT
dpc-5172	2	21	yin	yin	PROPN
dpc-5172	2	22	huang1	huang1	PROPN
dpc-5172	2	23	,	,	PUNCT
dpc-5172	2	24	leon	leon	PROPN
dpc-5172	2	25	tsung	tsung	PROPN
dpc-5172	2	26	-	-	PUNCT
dpc-5172	2	27	ju	ju	PROPN
dpc-5172	2	28	lee2,3,4	lee2,3,4	ADJ
dpc-5172	2	29	1	1	NUM
dpc-5172	2	30	department	department	NOUN
dpc-5172	2	31	of	of	ADP
dpc-5172	2	32	general	general	ADJ
dpc-5172	2	33	medicine	medicine	NOUN
dpc-5172	2	34	,	,	PUNCT
dpc-5172	2	35	taipei	taipei	PROPN
dpc-5172	2	36	medical	medical	PROPN
dpc-5172	2	37	university	university	PROPN
dpc-5172	2	38	hospital	hospital	NOUN
dpc-5172	2	39	,	,	PUNCT
dpc-5172	2	40	taipei	taipei	PROPN
dpc-5172	2	41	medical	medical	PROPN
dpc-5172	2	42	university	university	PROPN
dpc-5172	2	43	,	,	PUNCT
dpc-5172	2	44	taipei	taipei	PROPN
dpc-5172	2	45	,	,	PUNCT
dpc-5172	2	46	taiwan	taiwan	PROPN
dpc-5172	2	47	2	2	NUM
dpc-5172	2	48	graduate	graduate	PROPN
dpc-5172	2	49	institute	institute	NOUN
dpc-5172	2	50	of	of	ADP
dpc-5172	2	51	clinical	clinical	ADJ
dpc-5172	2	52	medicine	medicine	NOUN
dpc-5172	2	53	,	,	PUNCT
dpc-5172	2	54	taipei	taipei	PROPN
dpc-5172	2	55	medical	medical	PROPN
dpc-5172	2	56	university	university	PROPN
dpc-5172	2	57	,	,	PUNCT
dpc-5172	2	58	taipei	taipei	PROPN
dpc-5172	2	59	,	,	PUNCT
dpc-5172	2	60	taiwan	taiwan	PROPN
dpc-5172	2	61	3	3	NUM
dpc-5172	2	62	department	department	PROPN
dpc-5172	2	63	of	of	ADP
dpc-5172	2	64	dermatology	dermatology	NOUN
dpc-5172	2	65	,	,	PUNCT
dpc-5172	2	66	taipei	taipei	PROPN
dpc-5172	2	67	medical	medical	PROPN
dpc-5172	2	68	university	university	PROPN
dpc-5172	2	69	hospital	hospital	NOUN
dpc-5172	2	70	,	,	PUNCT
dpc-5172	2	71	taipei	taipei	PROPN
dpc-5172	2	72	medical	medical	PROPN
dpc-5172	2	73	university	university	PROPN
dpc-5172	2	74	,	,	PUNCT
dpc-5172	2	75	taipei	taipei	PROPN
dpc-5172	2	76	,	,	PUNCT
dpc-5172	2	77	taiwan	taiwan	PROPN
dpc-5172	2	78	4	4	NUM
dpc-5172	2	79	department	department	NOUN
dpc-5172	2	80	of	of	ADP
dpc-5172	2	81	dermatology	dermatology	NOUN
dpc-5172	2	82	,	,	PUNCT
dpc-5172	2	83	school	school	NOUN
dpc-5172	2	84	of	of	ADP
dpc-5172	2	85	medicine	medicine	NOUN
dpc-5172	2	86	,	,	PUNCT
dpc-5172	2	87	college	college	NOUN
dpc-5172	2	88	of	of	ADP
dpc-5172	2	89	medicine	medicine	NOUN
dpc-5172	2	90	,	,	PUNCT
dpc-5172	2	91	taipei	taipei	PROPN
dpc-5172	2	92	medical	medical	PROPN
dpc-5172	2	93	university	university	PROPN
dpc-5172	2	94	,	,	PUNCT
dpc-5172	2	95	taipei	taipei	PROPN
dpc-5172	2	96	,	,	PUNCT
dpc-5172	2	97	taiwan	taiwan	PROPN
dpc-5172	2	98	key	key	ADJ
dpc-5172	2	99	words	word	NOUN
dpc-5172	2	100	:	:	PUNCT
dpc-5172	2	101	tretinoin	tretinoin	NOUN
dpc-5172	2	102	,	,	PUNCT
dpc-5172	2	103	photodamaged	photodamage	VERB
dpc-5172	2	104	skin	skin	NOUN
dpc-5172	2	105	,	,	PUNCT
dpc-5172	2	106	facial	facial	ADJ
dpc-5172	2	107	skin	skin	NOUN
dpc-5172	2	108	,	,	PUNCT
dpc-5172	2	109	systematic	systematic	ADJ
dpc-5172	2	110	review	review	NOUN
dpc-5172	2	111	,	,	PUNCT
dpc-5172	2	112	meta	meta	ADJ
dpc-5172	2	113	-	-	PUNCT
dpc-5172	2	114	analysis	analysis	NOUN
dpc-5172	2	115	citation	citation	NOUN
dpc-5172	2	116	:	:	PUNCT
dpc-5172	2	117	huang	huang	PROPN
dpc-5172	2	118	hy	hy	PROPN
dpc-5172	2	119	,	,	PUNCT
dpc-5172	2	120	lee	lee	PROPN
dpc-5172	2	121	ltj	ltj	PROPN
dpc-5172	2	122	.	.	PROPN
dpc-5172	2	123	tretinoin	tretinoin	PROPN
dpc-5172	2	124	for	for	ADP
dpc-5172	2	125	photodamaged	photodamage	VERB
dpc-5172	2	126	facial	facial	ADJ
dpc-5172	2	127	skin	skin	NOUN
dpc-5172	2	128	:	:	PUNCT
dpc-5172	2	129	systematic	systematic	ADJ
dpc-5172	2	130	review	review	NOUN
dpc-5172	2	131	and	and	CCONJ
dpc-5172	2	132	meta	meta	NOUN
dpc-5172	2	133	-	-	PUNCT
dpc-5172	2	134	analysis	analysis	NOUN
dpc-5172	2	135	of	of	ADP
dpc-5172	2	136	randomized	randomized	ADJ
dpc-5172	2	137	controlled	control	VERB
dpc-5172	2	138	trials	trial	NOUN
dpc-5172	2	139	.	.	PUNCT
dpc-5172	3	1	dermatol	dermatol	NOUN
dpc-5172	3	2	pract	pract	PROPN
dpc-5172	3	3	concept	concept	NOUN
dpc-5172	3	4	.	.	PUNCT
dpc-5172	4	1	2025;15(4):5172	2025;15(4):5172	NUM
dpc-5172	4	2	.	.	PUNCT
dpc-5172	5	1	doi	doi	PROPN
dpc-5172	5	2	:	:	PUNCT
dpc-5172	5	3	https://doi.org/10.5826/dpc.1504a5172	https://doi.org/10.5826/dpc.1504a5172	PROPN
dpc-5172	5	4	accepted	accept	VERB
dpc-5172	5	5	:	:	PUNCT
dpc-5172	5	6	june	june	PROPN
dpc-5172	5	7	22	22	NUM
dpc-5172	5	8	,	,	PUNCT
dpc-5172	5	9	2025	2025	NUM
dpc-5172	5	10	;	;	PUNCT
dpc-5172	5	11	published	publish	VERB
dpc-5172	5	12	:	:	PUNCT
dpc-5172	6	1	october	october	PROPN
dpc-5172	6	2	2025	2025	NUM
dpc-5172	6	3	copyright	copyright	NOUN
dpc-5172	6	4	:	:	PUNCT
dpc-5172	6	5	©	©	PROPN
dpc-5172	6	6	2025	2025	NUM
dpc-5172	6	7	huang	huang	PROPN
dpc-5172	6	8	et	et	PROPN
dpc-5172	6	9	al	al	PROPN
dpc-5172	6	10	.	.	PUNCT
dpc-5172	7	1	this	this	PRON
dpc-5172	7	2	is	be	AUX
dpc-5172	7	3	an	an	DET
dpc-5172	7	4	open	open	ADJ
dpc-5172	7	5	-	-	PUNCT
dpc-5172	7	6	access	access	NOUN
dpc-5172	7	7	article	article	NOUN
dpc-5172	7	8	distributed	distribute	VERB
dpc-5172	7	9	under	under	ADP
dpc-5172	7	10	the	the	DET
dpc-5172	7	11	terms	term	NOUN
dpc-5172	7	12	of	of	ADP
dpc-5172	7	13	the	the	DET
dpc-5172	7	14	creative	creative	ADJ
dpc-5172	7	15	commons	common	NOUN
dpc-5172	7	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-5172	7	17	license	license	NOUN
dpc-5172	7	18	(	(	PUNCT
dpc-5172	7	19	by	by	ADP
dpc-5172	7	20	-	-	PUNCT
dpc-5172	7	21	nc-4.0	nc-4.0	NOUN
dpc-5172	7	22	)	)	PUNCT
dpc-5172	7	23	,	,	PUNCT
dpc-5172	7	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-5172	7	25	,	,	PUNCT
dpc-5172	7	26	which	which	PRON
dpc-5172	7	27	permits	permit	VERB
dpc-5172	7	28	unrestricted	unrestricted	ADJ
dpc-5172	7	29	noncommercial	noncommercial	ADJ
dpc-5172	7	30	use	use	NOUN
dpc-5172	7	31	,	,	PUNCT
dpc-5172	7	32	distribution	distribution	NOUN
dpc-5172	7	33	,	,	PUNCT
dpc-5172	7	34	and	and	CCONJ
dpc-5172	7	35	reproduction	reproduction	NOUN
dpc-5172	7	36	in	in	ADP
dpc-5172	7	37	any	any	DET
dpc-5172	7	38	medium	medium	NOUN
dpc-5172	7	39	,	,	PUNCT
dpc-5172	7	40	provided	provide	VERB
dpc-5172	7	41	the	the	DET
dpc-5172	7	42	original	original	ADJ
dpc-5172	7	43	authors	author	NOUN
dpc-5172	7	44	and	and	CCONJ
dpc-5172	7	45	source	source	NOUN
dpc-5172	7	46	are	be	AUX
dpc-5172	7	47	credited	credit	VERB
dpc-5172	7	48	.	.	PUNCT
dpc-5172	8	1	funding	funding	NOUN
dpc-5172	8	2	:	:	PUNCT
dpc-5172	8	3	none	none	NOUN
dpc-5172	8	4	.	.	PUNCT
dpc-5172	9	1	competing	compete	VERB
dpc-5172	9	2	interests	interest	NOUN
dpc-5172	9	3	:	:	PUNCT
dpc-5172	9	4	none	none	NOUN
dpc-5172	9	5	.	.	PUNCT
dpc-5172	10	1	authorship	authorship	NOUN
dpc-5172	10	2	:	:	PUNCT
dpc-5172	10	3	all	all	DET
dpc-5172	10	4	authors	author	NOUN
dpc-5172	10	5	have	have	AUX
dpc-5172	10	6	contributed	contribute	VERB
dpc-5172	10	7	significantly	significantly	ADV
dpc-5172	10	8	to	to	ADP
dpc-5172	10	9	this	this	DET
dpc-5172	10	10	publication	publication	NOUN
dpc-5172	10	11	.	.	PUNCT
dpc-5172	11	1	corresponding	correspond	VERB
dpc-5172	11	2	author	author	NOUN
dpc-5172	11	3	:	:	PUNCT
dpc-5172	11	4	corresponding	correspond	VERB
dpc-5172	11	5	author	author	NOUN
dpc-5172	11	6	:	:	PUNCT
dpc-5172	11	7	leon	leon	PROPN
dpc-5172	11	8	tsung	tsung	PROPN
dpc-5172	11	9	-	-	PUNCT
dpc-5172	11	10	ju	ju	PROPN
dpc-5172	11	11	lee	lee	PROPN
dpc-5172	11	12	,	,	PUNCT
dpc-5172	11	13	department	department	PROPN
dpc-5172	11	14	of	of	ADP
dpc-5172	11	15	dermatology	dermatology	NOUN
dpc-5172	11	16	,	,	PUNCT
dpc-5172	11	17	taipei	taipei	PROPN
dpc-5172	11	18	medical	medical	PROPN
dpc-5172	11	19	university	university	PROPN
dpc-5172	11	20	hospital	hospital	NOUN
dpc-5172	11	21	,	,	PUNCT
dpc-5172	11	22	no	no	INTJ
dpc-5172	11	23	.	.	NOUN
dpc-5172	11	24	252	252	NUM
dpc-5172	11	25	,	,	PUNCT
dpc-5172	11	26	wuxing	wuxing	ADJ
dpc-5172	11	27	st	st	PROPN
dpc-5172	11	28	,	,	PUNCT
dpc-5172	11	29	xinyi	xinyi	PROPN
dpc-5172	11	30	district	district	PROPN
dpc-5172	11	31	,	,	PUNCT
dpc-5172	11	32	taipei	taipei	PROPN
dpc-5172	11	33	city	city	PROPN
dpc-5172	11	34	,	,	PUNCT
dpc-5172	11	35	110	110	NUM
dpc-5172	11	36	,	,	PUNCT
dpc-5172	11	37	taiwan	taiwan	PROPN
dpc-5172	11	38	.	.	PUNCT
dpc-5172	12	1	orcid	orcid	PROPN
dpc-5172	13	1	i	i	PRON
dpc-5172	13	2	d	d	NOUN
dpc-5172	13	3	:	:	PUNCT
dpc-5172	13	4	0000	0000	NUM
dpc-5172	13	5	-	-	PUNCT
dpc-5172	13	6	0001	0001	NUM
dpc-5172	13	7	-	-	PUNCT
dpc-5172	13	8	6652	6652	NUM
dpc-5172	13	9	-	-	SYM
dpc-5172	13	10	4390	4390	NUM
dpc-5172	13	11	.	.	PUNCT
dpc-5172	14	1	e	e	X
dpc-5172	14	2	-	-	NOUN
dpc-5172	14	3	mail	mail	NOUN
dpc-5172	14	4	:	:	PUNCT
dpc-5172	14	5	tj.lee.skin@gmail.com	tj.lee.skin@gmail.com	X
dpc-5172	14	6	introduction	introduction	NOUN
dpc-5172	14	7	:	:	PUNCT
dpc-5172	14	8	randomized	randomize	VERB
dpc-5172	14	9	controlled	control	VERB
dpc-5172	14	10	trials	trial	NOUN
dpc-5172	14	11	have	have	AUX
dpc-5172	14	12	suggested	suggest	VERB
dpc-5172	14	13	that	that	SCONJ
dpc-5172	14	14	tretinoin	tretinoin	NOUN
dpc-5172	14	15	,	,	PUNCT
dpc-5172	14	16	a	a	DET
dpc-5172	14	17	topical	topical	ADJ
dpc-5172	14	18	retinoid	retinoid	NOUN
dpc-5172	14	19	,	,	PUNCT
dpc-5172	14	20	can	can	AUX
dpc-5172	14	21	improve	improve	VERB
dpc-5172	14	22	wrinkling	wrinkle	VERB
dpc-5172	14	23	in	in	ADP
dpc-5172	14	24	photodamaged	photodamage	VERB
dpc-5172	14	25	skin	skin	NOUN
dpc-5172	14	26	;	;	PUNCT
dpc-5172	14	27	however	however	ADV
dpc-5172	14	28	,	,	PUNCT
dpc-5172	14	29	its	its	PRON
dpc-5172	14	30	overall	overall	ADJ
dpc-5172	14	31	effectiveness	effectiveness	NOUN
dpc-5172	14	32	remains	remain	VERB
dpc-5172	14	33	subject	subject	ADJ
dpc-5172	14	34	of	of	ADP
dpc-5172	14	35	debate	debate	NOUN
dpc-5172	14	36	.	.	PUNCT
dpc-5172	15	1	objectives	objective	NOUN
dpc-5172	15	2	:	:	PUNCT
dpc-5172	15	3	this	this	DET
dpc-5172	15	4	study	study	NOUN
dpc-5172	15	5	evaluated	evaluate	VERB
dpc-5172	15	6	the	the	DET
dpc-5172	15	7	efficacy	efficacy	NOUN
dpc-5172	15	8	and	and	CCONJ
dpc-5172	15	9	safety	safety	NOUN
dpc-5172	15	10	of	of	ADP
dpc-5172	15	11	tretinoin	tretinoin	NOUN
dpc-5172	15	12	in	in	ADP
dpc-5172	15	13	treating	treat	VERB
dpc-5172	15	14	facial	facial	ADJ
dpc-5172	15	15	wrinkles	wrinkle	NOUN
dpc-5172	15	16	induced	induce	VERB
dpc-5172	15	17	by	by	ADP
dpc-5172	15	18	photodamage	photodamage	NOUN
dpc-5172	15	19	.	.	PUNCT
dpc-5172	16	1	method	method	NOUN
dpc-5172	16	2	:	:	PUNCT
dpc-5172	16	3	we	we	PRON
dpc-5172	16	4	systematically	systematically	ADV
dpc-5172	16	5	searched	search	VERB
dpc-5172	16	6	the	the	DET
dpc-5172	16	7	pubmed	pubmed	PROPN
dpc-5172	16	8	,	,	PUNCT
dpc-5172	16	9	embase	embase	NOUN
dpc-5172	16	10	,	,	PUNCT
dpc-5172	16	11	and	and	CCONJ
dpc-5172	16	12	cochrane	cochrane	NOUN
dpc-5172	16	13	central	central	ADJ
dpc-5172	16	14	databases	database	NOUN
dpc-5172	16	15	from	from	ADP
dpc-5172	16	16	their	their	PRON
dpc-5172	16	17	inception	inception	NOUN
dpc-5172	16	18	to	to	ADP
dpc-5172	16	19	16	16	NUM
dpc-5172	16	20	january	january	NOUN
dpc-5172	16	21	2024	2024	NUM
dpc-5172	16	22	to	to	PART
dpc-5172	16	23	identify	identify	VERB
dpc-5172	16	24	randomized	randomize	VERB
dpc-5172	16	25	controlled	control	VERB
dpc-5172	16	26	trials	trial	NOUN
dpc-5172	16	27	comparing	compare	VERB
dpc-5172	16	28	topical	topical	ADJ
dpc-5172	16	29	tretinoin	tretinoin	NOUN
dpc-5172	16	30	with	with	ADP
dpc-5172	16	31	vehicle	vehicle	NOUN
dpc-5172	16	32	treatments	treatment	NOUN
dpc-5172	16	33	.	.	PUNCT
dpc-5172	17	1	data	datum	NOUN
dpc-5172	17	2	were	be	AUX
dpc-5172	17	3	synthesized	synthesize	VERB
dpc-5172	17	4	using	use	VERB
dpc-5172	17	5	a	a	DET
dpc-5172	17	6	random	random	ADJ
dpc-5172	17	7	effects	effect	NOUN
dpc-5172	17	8	model	model	NOUN
dpc-5172	17	9	,	,	PUNCT
dpc-5172	17	10	and	and	CCONJ
dpc-5172	17	11	sensitivity	sensitivity	NOUN
dpc-5172	17	12	analyses	analysis	NOUN
dpc-5172	17	13	were	be	AUX
dpc-5172	17	14	performed	perform	VERB
dpc-5172	17	15	to	to	PART
dpc-5172	17	16	evaluate	evaluate	VERB
dpc-5172	17	17	the	the	DET
dpc-5172	17	18	robustness	robustness	NOUN
dpc-5172	17	19	of	of	ADP
dpc-5172	17	20	the	the	DET
dpc-5172	17	21	results	result	NOUN
dpc-5172	17	22	in	in	ADP
dpc-5172	17	23	the	the	DET
dpc-5172	17	24	presence	presence	NOUN
dpc-5172	17	25	of	of	ADP
dpc-5172	17	26	potential	potential	ADJ
dpc-5172	17	27	bias	bias	NOUN
dpc-5172	17	28	.	.	PUNCT
dpc-5172	18	1	results	result	NOUN
dpc-5172	18	2	:	:	PUNCT
dpc-5172	18	3	this	this	DET
dpc-5172	18	4	study	study	NOUN
dpc-5172	18	5	identified	identify	VERB
dpc-5172	18	6	eight	eight	NUM
dpc-5172	18	7	trials	trial	NOUN
dpc-5172	18	8	(	(	PUNCT
dpc-5172	18	9	1,361	1,361	NUM
dpc-5172	18	10	patients	patient	NOUN
dpc-5172	18	11	;	;	PUNCT
dpc-5172	18	12	median	median	ADJ
dpc-5172	18	13	age	age	NOUN
dpc-5172	18	14	range	range	NOUN
dpc-5172	18	15	29–76	29–76	NUM
dpc-5172	18	16	years	year	NOUN
dpc-5172	18	17	;	;	PUNCT
dpc-5172	18	18	average	average	ADJ
dpc-5172	18	19	follow	follow	VERB
dpc-5172	18	20	-	-	PUNCT
dpc-5172	18	21	up	up	ADP
dpc-5172	18	22	duration	duration	NOUN
dpc-5172	18	23	,	,	PUNCT
dpc-5172	18	24	16	16	NUM
dpc-5172	18	25	weeks	week	NOUN
dpc-5172	18	26	to	to	ADP
dpc-5172	18	27	2	2	NUM
dpc-5172	18	28	years	year	NOUN
dpc-5172	18	29	)	)	PUNCT
dpc-5172	18	30	that	that	PRON
dpc-5172	18	31	met	meet	VERB
dpc-5172	18	32	the	the	DET
dpc-5172	18	33	inclusion	inclusion	NOUN
dpc-5172	18	34	criteria	criterion	NOUN
dpc-5172	18	35	.	.	PUNCT
dpc-5172	19	1	compared	compare	VERB
dpc-5172	19	2	with	with	ADP
dpc-5172	19	3	the	the	DET
dpc-5172	19	4	vehicle	vehicle	NOUN
dpc-5172	19	5	,	,	PUNCT
dpc-5172	19	6	topical	topical	ADJ
dpc-5172	19	7	tretinoin	tretinoin	NOUN
dpc-5172	19	8	significantly	significantly	ADV
dpc-5172	19	9	improved	improve	VERB
dpc-5172	19	10	clinical	clinical	ADJ
dpc-5172	19	11	signs	sign	NOUN
dpc-5172	19	12	of	of	ADP
dpc-5172	19	13	facial	facial	ADJ
dpc-5172	19	14	photodamage	photodamage	NOUN
dpc-5172	19	15	.	.	PUNCT
dpc-5172	20	1	improvements	improvement	NOUN
dpc-5172	20	2	were	be	AUX
dpc-5172	20	3	observed	observe	VERB
dpc-5172	20	4	in	in	ADP
dpc-5172	20	5	both	both	DET
dpc-5172	20	6	fine	fine	ADJ
dpc-5172	20	7	wrinkles	wrinkle	NOUN
dpc-5172	20	8	(	(	PUNCT
dpc-5172	20	9	mean	mean	INTJ
dpc-5172	20	10	difference	difference	NOUN
dpc-5172	21	1	[	[	X
dpc-5172	21	2	md	md	X
dpc-5172	21	3	]	]	X
dpc-5172	21	4	:	:	PUNCT
dpc-5172	21	5	0.412	0.412	NUM
dpc-5172	21	6	;	;	PUNCT
dpc-5172	21	7	95	95	NUM
dpc-5172	21	8	%	%	NOUN
dpc-5172	21	9	confidence	confidence	NOUN
dpc-5172	21	10	interval	interval	NOUN
dpc-5172	22	1	[	[	X
dpc-5172	22	2	ci	ci	X
dpc-5172	22	3	]	]	X
dpc-5172	22	4	:	:	PUNCT
dpc-5172	22	5	0.233	0.233	NUM
dpc-5172	22	6	–	–	PUNCT
dpc-5172	22	7	0.590	0.590	NUM
dpc-5172	22	8	;	;	PUNCT
dpc-5172	22	9	p<0.001	p<0.001	X
dpc-5172	22	10	)	)	PUNCT
dpc-5172	22	11	and	and	CCONJ
dpc-5172	22	12	coarse	coarse	ADJ
dpc-5172	22	13	wrinkles	wrinkle	NOUN
dpc-5172	22	14	(	(	PUNCT
dpc-5172	22	15	md	md	PROPN
dpc-5172	22	16	:	:	PUNCT
dpc-5172	22	17	0.245	0.245	NUM
dpc-5172	22	18	;	;	PUNCT
dpc-5172	22	19	95	95	NUM
dpc-5172	22	20	%	%	NOUN
dpc-5172	22	21	ci	ci	NOUN
dpc-5172	22	22	:	:	PUNCT
dpc-5172	22	23	0.119–0.370	0.119–0.370	NUM
dpc-5172	22	24	;	;	PUNCT
dpc-5172	22	25	p<0.001	p<0.001	X
dpc-5172	22	26	)	)	PUNCT
dpc-5172	22	27	.	.	PUNCT
dpc-5172	23	1	sensitivity	sensitivity	NOUN
dpc-5172	23	2	analyses	analysis	NOUN
dpc-5172	23	3	confirmed	confirm	VERB
dpc-5172	23	4	the	the	DET
dpc-5172	23	5	robustness	robustness	NOUN
dpc-5172	23	6	of	of	ADP
dpc-5172	23	7	these	these	DET
dpc-5172	23	8	findings	finding	NOUN
dpc-5172	23	9	.	.	PUNCT
dpc-5172	24	1	conclusion	conclusion	NOUN
dpc-5172	24	2	:	:	PUNCT
dpc-5172	24	3	topical	topical	ADJ
dpc-5172	24	4	tretinoin	tretinoin	NOUN
dpc-5172	24	5	is	be	AUX
dpc-5172	24	6	a	a	DET
dpc-5172	24	7	safe	safe	ADJ
dpc-5172	24	8	and	and	CCONJ
dpc-5172	24	9	effective	effective	ADJ
dpc-5172	24	10	treatment	treatment	NOUN
dpc-5172	24	11	for	for	ADP
dpc-5172	24	12	fine	fine	ADJ
dpc-5172	24	13	and	and	CCONJ
dpc-5172	24	14	coarse	coarse	ADJ
dpc-5172	24	15	facial	facial	ADJ
dpc-5172	24	16	wrinkles	wrinkle	NOUN
dpc-5172	24	17	resulting	result	VERB
dpc-5172	24	18	from	from	ADP
dpc-5172	24	19	photodamage	photodamage	NOUN
dpc-5172	24	20	.	.	PUNCT
dpc-5172	25	1	abstract	abstract	ADJ
dpc-5172	25	2	2	2	NUM
dpc-5172	25	3	review	review	NOUN
dpc-5172	25	4	|	|	ADV
dpc-5172	25	5	dermatol	dermatol	ADJ
dpc-5172	25	6	pract	pract	NOUN
dpc-5172	25	7	concept	concept	NOUN
dpc-5172	25	8	.	.	PUNCT
dpc-5172	26	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	26	2	introduction	introduction	NOUN
dpc-5172	26	3	the	the	DET
dpc-5172	26	4	widespread	widespread	ADJ
dpc-5172	26	5	use	use	NOUN
dpc-5172	26	6	of	of	ADP
dpc-5172	26	7	social	social	ADJ
dpc-5172	26	8	media	medium	NOUN
dpc-5172	26	9	has	have	AUX
dpc-5172	26	10	increased	increase	VERB
dpc-5172	26	11	people	people	NOUN
dpc-5172	26	12	’s	’s	PART
dpc-5172	26	13	self	self	NOUN
dpc-5172	26	14	-	-	PUNCT
dpc-5172	26	15	consciousness	consciousness	NOUN
dpc-5172	26	16	regarding	regard	VERB
dpc-5172	26	17	their	their	PRON
dpc-5172	26	18	facial	facial	ADJ
dpc-5172	26	19	appearance	appearance	NOUN
dpc-5172	26	20	.	.	PUNCT
dpc-5172	27	1	many	many	ADJ
dpc-5172	27	2	individuals	individual	NOUN
dpc-5172	27	3	consider	consider	VERB
dpc-5172	27	4	facial	facial	ADJ
dpc-5172	27	5	skin	skin	NOUN
dpc-5172	27	6	aging	age	VERB
dpc-5172	27	7	to	to	PART
dpc-5172	27	8	be	be	AUX
dpc-5172	27	9	undesirable	undesirable	ADJ
dpc-5172	27	10	and	and	CCONJ
dpc-5172	27	11	thus	thus	ADV
dpc-5172	27	12	seek	seek	VERB
dpc-5172	27	13	medical	medical	ADJ
dpc-5172	27	14	treatment	treatment	NOUN
dpc-5172	27	15	for	for	ADP
dpc-5172	27	16	it	it	PRON
dpc-5172	27	17	.	.	PUNCT
dpc-5172	28	1	such	such	ADJ
dpc-5172	28	2	aging	aging	NOUN
dpc-5172	28	3	can	can	AUX
dpc-5172	28	4	be	be	AUX
dpc-5172	28	5	either	either	CCONJ
dpc-5172	28	6	intrinsic	intrinsic	ADJ
dpc-5172	28	7	or	or	CCONJ
dpc-5172	28	8	extrinsic	extrinsic	ADJ
dpc-5172	28	9	.	.	PUNCT
dpc-5172	29	1	intrinsic	intrinsic	ADJ
dpc-5172	29	2	aging	age	VERB
dpc-5172	29	3	results	result	NOUN
dpc-5172	29	4	from	from	ADP
dpc-5172	29	5	unknown	unknown	ADJ
dpc-5172	29	6	endogenous	endogenous	ADJ
dpc-5172	29	7	factors	factor	NOUN
dpc-5172	29	8	and	and	CCONJ
dpc-5172	29	9	genetically	genetically	ADV
dpc-5172	29	10	programmed	program	VERB
dpc-5172	29	11	skin	skin	NOUN
dpc-5172	29	12	cell	cell	NOUN
dpc-5172	29	13	deterioration	deterioration	NOUN
dpc-5172	29	14	,	,	PUNCT
dpc-5172	29	15	which	which	PRON
dpc-5172	29	16	can	can	AUX
dpc-5172	29	17	lead	lead	VERB
dpc-5172	29	18	to	to	ADP
dpc-5172	29	19	epidermal	epidermal	ADJ
dpc-5172	29	20	or	or	CCONJ
dpc-5172	29	21	dermal	dermal	ADJ
dpc-5172	29	22	atrophy	atrophy	NOUN
dpc-5172	29	23	.	.	PUNCT
dpc-5172	30	1	skin	skin	NOUN
dpc-5172	30	2	affected	affect	VERB
dpc-5172	30	3	by	by	ADP
dpc-5172	30	4	intrinsic	intrinsic	ADJ
dpc-5172	30	5	aging	aging	NOUN
dpc-5172	30	6	typically	typically	ADV
dpc-5172	30	7	exhibits	exhibit	VERB
dpc-5172	30	8	thinning	thinning	NOUN
dpc-5172	30	9	,	,	PUNCT
dpc-5172	30	10	decreased	decrease	VERB
dpc-5172	30	11	elasticity	elasticity	NOUN
dpc-5172	30	12	,	,	PUNCT
dpc-5172	30	13	and	and	CCONJ
dpc-5172	30	14	deeper	deep	ADJ
dpc-5172	30	15	expression	expression	NOUN
dpc-5172	30	16	lines	line	NOUN
dpc-5172	30	17	.	.	PUNCT
dpc-5172	31	1	by	by	ADP
dpc-5172	31	2	contrast	contrast	NOUN
dpc-5172	31	3	,	,	PUNCT
dpc-5172	31	4	extrinsic	extrinsic	ADJ
dpc-5172	31	5	aging	aging	NOUN
dpc-5172	31	6	is	be	AUX
dpc-5172	31	7	caused	cause	VERB
dpc-5172	31	8	by	by	ADP
dpc-5172	31	9	environmental	environmental	ADJ
dpc-5172	31	10	factors	factor	NOUN
dpc-5172	31	11	,	,	PUNCT
dpc-5172	31	12	such	such	ADJ
dpc-5172	31	13	as	as	ADP
dpc-5172	31	14	sun	sun	NOUN
dpc-5172	31	15	exposure	exposure	NOUN
dpc-5172	31	16	.	.	PUNCT
dpc-5172	32	1	the	the	DET
dpc-5172	32	2	extrinsic	extrinsic	ADJ
dpc-5172	32	3	aging	aging	NOUN
dpc-5172	32	4	caused	cause	VERB
dpc-5172	32	5	by	by	ADP
dpc-5172	32	6	chronic	chronic	ADJ
dpc-5172	32	7	sun	sun	NOUN
dpc-5172	32	8	exposure	exposure	NOUN
dpc-5172	32	9	is	be	AUX
dpc-5172	32	10	referred	refer	VERB
dpc-5172	32	11	to	to	ADP
dpc-5172	32	12	as	as	ADP
dpc-5172	32	13	photoaging	photoaging	NOUN
dpc-5172	32	14	or	or	CCONJ
dpc-5172	32	15	photodamage	photodamage	NOUN
dpc-5172	32	16	,	,	PUNCT
dpc-5172	32	17	and	and	CCONJ
dpc-5172	32	18	it	it	PRON
dpc-5172	32	19	involves	involve	VERB
dpc-5172	32	20	epidermal	epidermal	ADJ
dpc-5172	32	21	dysplasia	dysplasia	NOUN
dpc-5172	32	22	,	,	PUNCT
dpc-5172	32	23	dermal	dermal	ADJ
dpc-5172	32	24	damage	damage	NOUN
dpc-5172	32	25	,	,	PUNCT
dpc-5172	32	26	substantial	substantial	ADJ
dpc-5172	32	27	elastosis	elastosis	NOUN
dpc-5172	32	28	,	,	PUNCT
dpc-5172	32	29	and	and	CCONJ
dpc-5172	32	30	collagen	collagen	NOUN
dpc-5172	32	31	loss	loss	NOUN
dpc-5172	32	32	[	[	X
dpc-5172	32	33	1	1	NUM
dpc-5172	32	34	]	]	PUNCT
dpc-5172	32	35	.	.	PUNCT
dpc-5172	33	1	facial	facial	ADJ
dpc-5172	33	2	manifestations	manifestation	NOUN
dpc-5172	33	3	of	of	ADP
dpc-5172	33	4	photoaging	photoaging	NOUN
dpc-5172	33	5	include	include	VERB
dpc-5172	33	6	fine	fine	ADJ
dpc-5172	33	7	and	and	CCONJ
dpc-5172	33	8	coarse	coarse	ADJ
dpc-5172	33	9	wrinkles	wrinkle	NOUN
dpc-5172	33	10	,	,	PUNCT
dpc-5172	33	11	irregular	irregular	ADJ
dpc-5172	33	12	pigmentation	pigmentation	NOUN
dpc-5172	33	13	,	,	PUNCT
dpc-5172	33	14	and	and	CCONJ
dpc-5172	33	15	changes	change	NOUN
dpc-5172	33	16	in	in	ADP
dpc-5172	33	17	skin	skin	NOUN
dpc-5172	33	18	texture	texture	NOUN
dpc-5172	33	19	,	,	PUNCT
dpc-5172	33	20	elasticity	elasticity	NOUN
dpc-5172	33	21	,	,	PUNCT
dpc-5172	33	22	and	and	CCONJ
dpc-5172	33	23	thickness	thickness	NOUN
dpc-5172	33	24	;	;	PUNCT
dpc-5172	33	25	they	they	PRON
dpc-5172	33	26	result	result	VERB
dpc-5172	33	27	from	from	ADP
dpc-5172	33	28	environmental	environmental	ADJ
dpc-5172	33	29	influences	influence	NOUN
dpc-5172	33	30	rather	rather	ADV
dpc-5172	33	31	than	than	ADP
dpc-5172	33	32	the	the	DET
dpc-5172	33	33	natural	natural	ADJ
dpc-5172	33	34	progression	progression	NOUN
dpc-5172	33	35	of	of	ADP
dpc-5172	33	36	intrinsic	intrinsic	ADJ
dpc-5172	33	37	aging	aging	NOUN
dpc-5172	33	38	[	[	X
dpc-5172	33	39	2	2	NUM
dpc-5172	33	40	]	]	PUNCT
dpc-5172	33	41	.	.	PUNCT
dpc-5172	34	1	photodamage	photodamage	NOUN
dpc-5172	34	2	is	be	AUX
dpc-5172	34	3	associated	associate	VERB
dpc-5172	34	4	with	with	ADP
dpc-5172	34	5	both	both	CCONJ
dpc-5172	34	6	undesirable	undesirable	ADJ
dpc-5172	34	7	cosmetic	cosmetic	ADJ
dpc-5172	34	8	outcomes	outcome	NOUN
dpc-5172	34	9	and	and	CCONJ
dpc-5172	34	10	pathological	pathological	ADJ
dpc-5172	34	11	changes	change	NOUN
dpc-5172	34	12	,	,	PUNCT
dpc-5172	34	13	including	include	VERB
dpc-5172	34	14	the	the	DET
dpc-5172	34	15	development	development	NOUN
dpc-5172	34	16	of	of	ADP
dpc-5172	34	17	benign	benign	ADJ
dpc-5172	34	18	and	and	CCONJ
dpc-5172	34	19	malignant	malignant	ADJ
dpc-5172	34	20	tumors	tumor	NOUN
dpc-5172	35	1	[	[	X
dpc-5172	35	2	2	2	NUM
dpc-5172	35	3	]	]	PUNCT
dpc-5172	35	4	.	.	PUNCT
dpc-5172	36	1	many	many	ADJ
dpc-5172	36	2	individuals	individual	NOUN
dpc-5172	36	3	seek	seek	VERB
dpc-5172	36	4	treatment	treatment	NOUN
dpc-5172	36	5	to	to	PART
dpc-5172	36	6	address	address	VERB
dpc-5172	36	7	these	these	DET
dpc-5172	36	8	aesthetic	aesthetic	ADJ
dpc-5172	36	9	concerns	concern	NOUN
dpc-5172	36	10	and	and	CCONJ
dpc-5172	36	11	manage	manage	VERB
dpc-5172	36	12	the	the	DET
dpc-5172	36	13	underlying	underlying	ADJ
dpc-5172	36	14	pathological	pathological	ADJ
dpc-5172	36	15	problems	problem	NOUN
dpc-5172	36	16	related	relate	VERB
dpc-5172	36	17	to	to	ADP
dpc-5172	36	18	photodamage	photodamage	NOUN
dpc-5172	36	19	to	to	ADP
dpc-5172	36	20	facial	facial	ADJ
dpc-5172	36	21	skin	skin	NOUN
dpc-5172	36	22	.	.	PUNCT
dpc-5172	37	1	facial	facial	ADJ
dpc-5172	37	2	wrinkles	wrinkle	NOUN
dpc-5172	37	3	are	be	AUX
dpc-5172	37	4	a	a	DET
dpc-5172	37	5	common	common	ADJ
dpc-5172	37	6	manifestation	manifestation	NOUN
dpc-5172	37	7	of	of	ADP
dpc-5172	37	8	skin	skin	NOUN
dpc-5172	37	9	aging	age	VERB
dpc-5172	37	10	and	and	CCONJ
dpc-5172	37	11	are	be	AUX
dpc-5172	37	12	one	one	NUM
dpc-5172	37	13	of	of	ADP
dpc-5172	37	14	the	the	DET
dpc-5172	37	15	most	most	ADV
dpc-5172	37	16	prominent	prominent	ADJ
dpc-5172	37	17	features	feature	NOUN
dpc-5172	37	18	of	of	ADP
dpc-5172	37	19	photoaging	photoage	VERB
dpc-5172	37	20	.	.	PUNCT
dpc-5172	38	1	such	such	ADJ
dpc-5172	38	2	wrinkles	wrinkle	NOUN
dpc-5172	38	3	are	be	AUX
dpc-5172	38	4	generally	generally	ADV
dpc-5172	38	5	categorized	categorize	VERB
dpc-5172	38	6	into	into	ADP
dpc-5172	38	7	two	two	NUM
dpc-5172	38	8	types	type	NOUN
dpc-5172	38	9	:	:	PUNCT
dpc-5172	38	10	fine	fine	ADJ
dpc-5172	38	11	wrinkles	wrinkle	NOUN
dpc-5172	38	12	and	and	CCONJ
dpc-5172	38	13	coarse	coarse	ADJ
dpc-5172	38	14	wrinkles	wrinkle	NOUN
dpc-5172	38	15	.	.	PUNCT
dpc-5172	39	1	fine	fine	ADJ
dpc-5172	39	2	wrinkles	wrinkle	NOUN
dpc-5172	39	3	appear	appear	VERB
dpc-5172	39	4	as	as	ADP
dpc-5172	39	5	small	small	ADJ
dpc-5172	39	6	folds	fold	NOUN
dpc-5172	39	7	in	in	ADP
dpc-5172	39	8	the	the	DET
dpc-5172	39	9	superficial	superficial	ADJ
dpc-5172	39	10	epidermal	epidermal	ADJ
dpc-5172	39	11	layers	layer	NOUN
dpc-5172	39	12	and	and	CCONJ
dpc-5172	39	13	are	be	AUX
dpc-5172	39	14	typically	typically	ADV
dpc-5172	39	15	caused	cause	VERB
dpc-5172	39	16	by	by	ADP
dpc-5172	39	17	skin	skin	NOUN
dpc-5172	39	18	dryness	dryness	NOUN
dpc-5172	39	19	and	and	CCONJ
dpc-5172	39	20	photoaging	photoaging	NOUN
dpc-5172	39	21	.	.	PUNCT
dpc-5172	40	1	by	by	ADP
dpc-5172	40	2	contrast	contrast	NOUN
dpc-5172	40	3	,	,	PUNCT
dpc-5172	40	4	coarse	coarse	ADJ
dpc-5172	40	5	wrinkles	wrinkle	NOUN
dpc-5172	40	6	are	be	AUX
dpc-5172	40	7	deeper	deep	ADJ
dpc-5172	40	8	folds	fold	NOUN
dpc-5172	40	9	within	within	ADP
dpc-5172	40	10	the	the	DET
dpc-5172	40	11	dermal	dermal	ADJ
dpc-5172	40	12	layer	layer	NOUN
dpc-5172	40	13	and	and	CCONJ
dpc-5172	40	14	primarily	primarily	ADV
dpc-5172	40	15	result	result	VERB
dpc-5172	40	16	from	from	ADP
dpc-5172	40	17	collagen	collagen	NOUN
dpc-5172	40	18	and	and	CCONJ
dpc-5172	40	19	elastin	elastin	NOUN
dpc-5172	40	20	loss	loss	NOUN
dpc-5172	40	21	.	.	PUNCT
dpc-5172	41	1	topical	topical	ADJ
dpc-5172	41	2	retinoids	retinoid	NOUN
dpc-5172	41	3	,	,	PUNCT
dpc-5172	41	4	which	which	PRON
dpc-5172	41	5	are	be	AUX
dpc-5172	41	6	derivatives	derivative	NOUN
dpc-5172	41	7	of	of	ADP
dpc-5172	41	8	vitamin	vitamin	NOUN
dpc-5172	41	9	a	a	PRON
dpc-5172	41	10	,	,	PUNCT
dpc-5172	41	11	promote	promote	VERB
dpc-5172	41	12	collagen	collagen	NOUN
dpc-5172	41	13	synthesis	synthesis	NOUN
dpc-5172	41	14	and	and	CCONJ
dpc-5172	41	15	inhibit	inhibit	NOUN
dpc-5172	41	16	matrix	matrix	NOUN
dpc-5172	41	17	metalloproteinase	metalloproteinase	NOUN
dpc-5172	41	18	(	(	PUNCT
dpc-5172	41	19	mmp	mmp	NOUN
dpc-5172	41	20	)	)	PUNCT
dpc-5172	41	21	activity	activity	NOUN
dpc-5172	41	22	by	by	ADP
dpc-5172	41	23	binding	bind	VERB
dpc-5172	41	24	to	to	ADP
dpc-5172	41	25	and	and	CCONJ
dpc-5172	41	26	activating	activate	VERB
dpc-5172	41	27	retinoic	retinoic	ADJ
dpc-5172	41	28	acid	acid	NOUN
dpc-5172	41	29	receptors	receptor	NOUN
dpc-5172	41	30	.	.	PUNCT
dpc-5172	42	1	these	these	DET
dpc-5172	42	2	receptors	receptor	NOUN
dpc-5172	42	3	regulate	regulate	VERB
dpc-5172	42	4	the	the	DET
dpc-5172	42	5	transcription	transcription	NOUN
dpc-5172	42	6	of	of	ADP
dpc-5172	42	7	genes	gene	NOUN
dpc-5172	42	8	responsive	responsive	ADJ
dpc-5172	42	9	to	to	ADP
dpc-5172	42	10	retinoic	retinoic	NOUN
dpc-5172	42	11	acid	acid	NOUN
dpc-5172	42	12	,	,	PUNCT
dpc-5172	42	13	thereby	thereby	ADV
dpc-5172	42	14	facilitating	facilitate	VERB
dpc-5172	42	15	cell	cell	NOUN
dpc-5172	42	16	proliferation	proliferation	NOUN
dpc-5172	42	17	and	and	CCONJ
dpc-5172	42	18	differentiation	differentiation	NOUN
dpc-5172	42	19	.	.	PUNCT
dpc-5172	43	1	topical	topical	ADJ
dpc-5172	43	2	retinoids	retinoid	NOUN
dpc-5172	43	3	are	be	AUX
dpc-5172	43	4	widely	widely	ADV
dpc-5172	43	5	used	use	VERB
dpc-5172	43	6	to	to	PART
dpc-5172	43	7	treat	treat	VERB
dpc-5172	43	8	various	various	ADJ
dpc-5172	43	9	dermatological	dermatological	ADJ
dpc-5172	43	10	conditions	condition	NOUN
dpc-5172	43	11	,	,	PUNCT
dpc-5172	43	12	including	include	VERB
dpc-5172	43	13	photoaging	photoage	VERB
dpc-5172	43	14	,	,	PUNCT
dpc-5172	43	15	acne	acne	NOUN
dpc-5172	43	16	vulgaris	vulgaris	NOUN
dpc-5172	43	17	,	,	PUNCT
dpc-5172	43	18	psoriasis	psoriasis	NOUN
dpc-5172	43	19	,	,	PUNCT
dpc-5172	43	20	cutaneous	cutaneous	ADJ
dpc-5172	43	21	t	t	NOUN
dpc-5172	43	22	-	-	PUNCT
dpc-5172	43	23	cell	cell	NOUN
dpc-5172	43	24	lymphoma	lymphoma	NOUN
dpc-5172	43	25	,	,	PUNCT
dpc-5172	43	26	and	and	CCONJ
dpc-5172	43	27	kaposi	kaposi	PROPN
dpc-5172	43	28	’s	’s	PART
dpc-5172	43	29	sarcoma	sarcoma	NOUN
dpc-5172	43	30	.	.	PUNCT
dpc-5172	44	1	currently	currently	ADV
dpc-5172	44	2	,	,	PUNCT
dpc-5172	44	3	six	six	NUM
dpc-5172	44	4	classes	class	NOUN
dpc-5172	44	5	of	of	ADP
dpc-5172	44	6	topical	topical	ADJ
dpc-5172	44	7	retinoids	retinoid	NOUN
dpc-5172	44	8	are	be	AUX
dpc-5172	44	9	approved	approve	VERB
dpc-5172	44	10	for	for	ADP
dpc-5172	44	11	clinical	clinical	ADJ
dpc-5172	44	12	use	use	NOUN
dpc-5172	44	13	:	:	PUNCT
dpc-5172	44	14	tretinoin	tretinoin	PROPN
dpc-5172	44	15	(	(	PUNCT
dpc-5172	44	16	all	all	PROPN
dpc-5172	44	17	-	-	PUNCT
dpc-5172	44	18	trans	trans	ADJ
dpc-5172	44	19	-	-	ADJ
dpc-5172	44	20	retinoic	retinoic	ADJ
dpc-5172	44	21	acid	acid	NOUN
dpc-5172	44	22	)	)	PUNCT
dpc-5172	44	23	,	,	PUNCT
dpc-5172	44	24	adapalene	adapalene	NOUN
dpc-5172	44	25	,	,	PUNCT
dpc-5172	44	26	tazarotene	tazarotene	NOUN
dpc-5172	44	27	,	,	PUNCT
dpc-5172	44	28	trifarotene	trifarotene	NOUN
dpc-5172	44	29	,	,	PUNCT
dpc-5172	44	30	alitretinoin	alitretinoin	ADJ
dpc-5172	44	31	,	,	PUNCT
dpc-5172	44	32	and	and	CCONJ
dpc-5172	44	33	bexarotene	bexarotene	NOUN
dpc-5172	45	1	[	[	X
dpc-5172	45	2	3	3	NUM
dpc-5172	45	3	]	]	PUNCT
dpc-5172	45	4	.	.	PUNCT
dpc-5172	46	1	among	among	ADP
dpc-5172	46	2	these	these	PRON
dpc-5172	46	3	,	,	PUNCT
dpc-5172	46	4	tretinoin	tretinoin	PROPN
dpc-5172	46	5	is	be	AUX
dpc-5172	46	6	the	the	DET
dpc-5172	46	7	only	only	ADJ
dpc-5172	46	8	one	one	NUM
dpc-5172	46	9	that	that	PRON
dpc-5172	46	10	is	be	AUX
dpc-5172	46	11	effective	effective	ADJ
dpc-5172	46	12	at	at	ADP
dpc-5172	46	13	treating	treat	VERB
dpc-5172	46	14	photoaging	photoaging	NOUN
dpc-5172	46	15	and	and	CCONJ
dpc-5172	46	16	wrinkles	wrinkle	NOUN
dpc-5172	46	17	.	.	PUNCT
dpc-5172	47	1	tretinoin	tretinoin	PROPN
dpc-5172	47	2	operates	operate	VERB
dpc-5172	47	3	through	through	ADP
dpc-5172	47	4	two	two	NUM
dpc-5172	47	5	distinct	distinct	ADJ
dpc-5172	47	6	but	but	CCONJ
dpc-5172	47	7	synergistic	synergistic	ADJ
dpc-5172	47	8	molecular	molecular	ADJ
dpc-5172	47	9	mechanisms	mechanism	NOUN
dpc-5172	47	10	.	.	PUNCT
dpc-5172	48	1	first	first	ADV
dpc-5172	48	2	,	,	PUNCT
dpc-5172	48	3	when	when	SCONJ
dpc-5172	48	4	applied	apply	VERB
dpc-5172	48	5	prior	prior	ADV
dpc-5172	48	6	to	to	ADP
dpc-5172	48	7	exposure	exposure	NOUN
dpc-5172	48	8	to	to	ADP
dpc-5172	48	9	ultraviolet	ultraviolet	ADJ
dpc-5172	48	10	light	light	NOUN
dpc-5172	48	11	,	,	PUNCT
dpc-5172	48	12	tretinoin	tretinoin	PROPN
dpc-5172	48	13	inhibits	inhibit	VERB
dpc-5172	48	14	activator	activator	NOUN
dpc-5172	48	15	protein-1	protein-1	PROPN
dpc-5172	48	16	(	(	PUNCT
dpc-5172	48	17	ap-1	ap-1	NOUN
dpc-5172	48	18	)	)	PUNCT
dpc-5172	48	19	activity	activity	NOUN
dpc-5172	48	20	,	,	PUNCT
dpc-5172	48	21	which	which	PRON
dpc-5172	48	22	is	be	AUX
dpc-5172	48	23	a	a	DET
dpc-5172	48	24	key	key	ADJ
dpc-5172	48	25	driver	driver	NOUN
dpc-5172	48	26	of	of	ADP
dpc-5172	48	27	collagen	collagen	NOUN
dpc-5172	48	28	-	-	PUNCT
dpc-5172	48	29	degrading	degrade	VERB
dpc-5172	48	30	mmps	mmp	NOUN
dpc-5172	48	31	.	.	PUNCT
dpc-5172	49	1	second	second	ADJ
dpc-5172	49	2	,	,	PUNCT
dpc-5172	49	3	topical	topical	ADJ
dpc-5172	49	4	application	application	NOUN
dpc-5172	49	5	of	of	ADP
dpc-5172	49	6	tretinoin	tretinoin	PROPN
dpc-5172	49	7	stimulates	stimulate	VERB
dpc-5172	49	8	collagen	collagen	NOUN
dpc-5172	49	9	synthesis	synthesis	NOUN
dpc-5172	49	10	by	by	ADP
dpc-5172	49	11	upregulating	upregulate	VERB
dpc-5172	49	12	the	the	DET
dpc-5172	49	13	expression	expression	NOUN
dpc-5172	49	14	of	of	ADP
dpc-5172	49	15	type	type	NOUN
dpc-5172	50	1	i	i	PRON
dpc-5172	50	2	procollagen	procollagen	NOUN
dpc-5172	51	1	[	[	X
dpc-5172	51	2	3	3	NUM
dpc-5172	51	3	]	]	PUNCT
dpc-5172	51	4	.	.	PUNCT
dpc-5172	52	1	unlike	unlike	ADP
dpc-5172	52	2	intrinsic	intrinsic	ADJ
dpc-5172	52	3	aging	aging	NOUN
dpc-5172	52	4	,	,	PUNCT
dpc-5172	52	5	photoaging	photoage	VERB
dpc-5172	52	6	can	can	AUX
dpc-5172	52	7	be	be	AUX
dpc-5172	52	8	prevented	prevent	VERB
dpc-5172	52	9	by	by	ADP
dpc-5172	52	10	limiting	limit	VERB
dpc-5172	52	11	sun	sun	NOUN
dpc-5172	52	12	exposure	exposure	NOUN
dpc-5172	52	13	and	and	CCONJ
dpc-5172	52	14	applying	apply	VERB
dpc-5172	52	15	sunscreen	sunscreen	NOUN
dpc-5172	52	16	regularly	regularly	ADV
dpc-5172	52	17	[	[	X
dpc-5172	52	18	1,4,5	1,4,5	NUM
dpc-5172	52	19	]	]	PUNCT
dpc-5172	52	20	.	.	PUNCT
dpc-5172	53	1	several	several	ADJ
dpc-5172	53	2	alternative	alternative	ADJ
dpc-5172	53	3	therapies	therapy	NOUN
dpc-5172	53	4	have	have	AUX
dpc-5172	53	5	been	be	AUX
dpc-5172	53	6	developed	develop	VERB
dpc-5172	53	7	for	for	ADP
dpc-5172	53	8	managing	manage	VERB
dpc-5172	53	9	photoaging	photoaging	NOUN
dpc-5172	53	10	,	,	PUNCT
dpc-5172	53	11	including	include	VERB
dpc-5172	53	12	those	those	PRON
dpc-5172	53	13	involving	involve	VERB
dpc-5172	53	14	non	non	ADJ
dpc-5172	53	15	-	-	ADJ
dpc-5172	53	16	retinoid	retinoid	ADJ
dpc-5172	53	17	topical	topical	ADJ
dpc-5172	53	18	agents	agent	NOUN
dpc-5172	53	19	,	,	PUNCT
dpc-5172	53	20	chemical	chemical	NOUN
dpc-5172	53	21	peels	peel	NOUN
dpc-5172	53	22	,	,	PUNCT
dpc-5172	53	23	and	and	CCONJ
dpc-5172	53	24	laser	laser	NOUN
dpc-5172	53	25	resurfacing	resurfacing	NOUN
dpc-5172	53	26	.	.	PUNCT
dpc-5172	54	1	non	non	ADJ
dpc-5172	54	2	-	-	ADJ
dpc-5172	54	3	retinoid	retinoid	ADJ
dpc-5172	54	4	topical	topical	ADJ
dpc-5172	54	5	agents	agent	NOUN
dpc-5172	54	6	such	such	ADJ
dpc-5172	54	7	as	as	ADP
dpc-5172	54	8	vitamin	vitamin	NOUN
dpc-5172	54	9	c	c	NOUN
dpc-5172	54	10	,	,	PUNCT
dpc-5172	54	11	peptides	peptide	NOUN
dpc-5172	54	12	,	,	PUNCT
dpc-5172	54	13	and	and	CCONJ
dpc-5172	54	14	growth	growth	NOUN
dpc-5172	54	15	factors	factor	NOUN
dpc-5172	54	16	have	have	AUX
dpc-5172	54	17	demonstrated	demonstrate	VERB
dpc-5172	54	18	potential	potential	ADJ
dpc-5172	54	19	in	in	ADP
dpc-5172	54	20	addressing	address	VERB
dpc-5172	54	21	photoaging	photoage	VERB
dpc-5172	54	22	;	;	PUNCT
dpc-5172	54	23	however	however	ADV
dpc-5172	54	24	,	,	PUNCT
dpc-5172	54	25	their	their	PRON
dpc-5172	54	26	effectiveness	effectiveness	NOUN
dpc-5172	54	27	in	in	ADP
dpc-5172	54	28	reversing	reverse	VERB
dpc-5172	54	29	structural	structural	ADJ
dpc-5172	54	30	skin	skin	NOUN
dpc-5172	54	31	damage	damage	NOUN
dpc-5172	54	32	remains	remain	VERB
dpc-5172	54	33	limited	limited	ADJ
dpc-5172	54	34	[	[	X
dpc-5172	54	35	9,10	9,10	NUM
dpc-5172	54	36	]	]	X
dpc-5172	54	37	.	.	PUNCT
dpc-5172	55	1	in	in	ADP
dpc-5172	55	2	addition	addition	NOUN
dpc-5172	55	3	,	,	PUNCT
dpc-5172	55	4	chemical	chemical	NOUN
dpc-5172	55	5	peels	peel	NOUN
dpc-5172	55	6	and	and	CCONJ
dpc-5172	55	7	laser	laser	NOUN
dpc-5172	55	8	resurfacing	resurfacing	NOUN
dpc-5172	55	9	may	may	AUX
dpc-5172	55	10	improve	improve	VERB
dpc-5172	55	11	photoaging	photoage	VERB
dpc-5172	55	12	symptoms	symptom	NOUN
dpc-5172	55	13	but	but	CCONJ
dpc-5172	55	14	are	be	AUX
dpc-5172	55	15	associated	associate	VERB
dpc-5172	55	16	with	with	ADP
dpc-5172	55	17	risks	risk	NOUN
dpc-5172	55	18	such	such	ADJ
dpc-5172	55	19	as	as	ADP
dpc-5172	55	20	irritation	irritation	NOUN
dpc-5172	55	21	,	,	PUNCT
dpc-5172	55	22	prolonged	prolonged	ADJ
dpc-5172	55	23	recovery	recovery	NOUN
dpc-5172	55	24	time	time	NOUN
dpc-5172	55	25	,	,	PUNCT
dpc-5172	55	26	and	and	CCONJ
dpc-5172	55	27	outcome	outcome	VERB
dpc-5172	55	28	variability	variability	NOUN
dpc-5172	55	29	related	relate	VERB
dpc-5172	55	30	to	to	ADP
dpc-5172	55	31	skin	skin	NOUN
dpc-5172	55	32	type	type	NOUN
dpc-5172	56	1	[	[	X
dpc-5172	56	2	11,12	11,12	NOUN
dpc-5172	56	3	]	]	PUNCT
dpc-5172	56	4	.	.	PUNCT
dpc-5172	57	1	contemporary	contemporary	ADJ
dpc-5172	57	2	developments	development	NOUN
dpc-5172	57	3	have	have	AUX
dpc-5172	57	4	indicated	indicate	VERB
dpc-5172	57	5	that	that	SCONJ
dpc-5172	57	6	injectable	injectable	ADJ
dpc-5172	57	7	treatments	treatment	NOUN
dpc-5172	57	8	,	,	PUNCT
dpc-5172	57	9	including	include	VERB
dpc-5172	57	10	treatment	treatment	NOUN
dpc-5172	57	11	with	with	ADP
dpc-5172	57	12	hyaluronic	hyaluronic	ADJ
dpc-5172	57	13	acid	acid	NOUN
dpc-5172	57	14	and	and	CCONJ
dpc-5172	57	15	botulinum	botulinum	ADJ
dpc-5172	57	16	toxin	toxin	NOUN
dpc-5172	57	17	,	,	PUNCT
dpc-5172	57	18	may	may	AUX
dpc-5172	57	19	help	help	VERB
dpc-5172	57	20	reduce	reduce	VERB
dpc-5172	57	21	the	the	DET
dpc-5172	57	22	visibility	visibility	NOUN
dpc-5172	57	23	of	of	ADP
dpc-5172	57	24	blood	blood	NOUN
dpc-5172	57	25	vessels	vessel	NOUN
dpc-5172	57	26	in	in	ADP
dpc-5172	57	27	photodamaged	photodamage	VERB
dpc-5172	57	28	skin	skin	NOUN
dpc-5172	57	29	[	[	X
dpc-5172	57	30	13,14	13,14	NUM
dpc-5172	57	31	]	]	PUNCT
dpc-5172	57	32	.	.	PUNCT
dpc-5172	58	1	this	this	PRON
dpc-5172	58	2	is	be	AUX
dpc-5172	58	3	particularly	particularly	ADV
dpc-5172	58	4	relevant	relevant	ADJ
dpc-5172	58	5	for	for	ADP
dpc-5172	58	6	individuals	individual	NOUN
dpc-5172	58	7	with	with	ADP
dpc-5172	58	8	the	the	DET
dpc-5172	58	9	atrophic	atrophic	ADJ
dpc-5172	58	10	photoaging	photoage	VERB
dpc-5172	58	11	phenotype	phenotype	NOUN
dpc-5172	58	12	,	,	PUNCT
dpc-5172	58	13	who	who	PRON
dpc-5172	58	14	commonly	commonly	ADV
dpc-5172	58	15	exhibit	exhibit	VERB
dpc-5172	58	16	vascular	vascular	ADJ
dpc-5172	58	17	features	feature	NOUN
dpc-5172	58	18	such	such	ADJ
dpc-5172	58	19	as	as	ADP
dpc-5172	58	20	telangiectasias	telangiectasia	NOUN
dpc-5172	58	21	resulting	result	VERB
dpc-5172	58	22	from	from	ADP
dpc-5172	58	23	chronic	chronic	ADJ
dpc-5172	58	24	sun	sun	NOUN
dpc-5172	58	25	exposure	exposure	NOUN
dpc-5172	58	26	[	[	X
dpc-5172	58	27	13,15	13,15	NUM
dpc-5172	58	28	]	]	PUNCT
dpc-5172	58	29	.	.	PUNCT
dpc-5172	59	1	these	these	DET
dpc-5172	59	2	injectables	injectable	NOUN
dpc-5172	59	3	offer	offer	VERB
dpc-5172	59	4	a	a	DET
dpc-5172	59	5	noninvasive	noninvasive	ADJ
dpc-5172	59	6	approach	approach	NOUN
dpc-5172	59	7	to	to	ADP
dpc-5172	59	8	addressing	address	VERB
dpc-5172	59	9	vascular	vascular	ADJ
dpc-5172	59	10	changes	change	NOUN
dpc-5172	59	11	commonly	commonly	ADV
dpc-5172	59	12	observed	observe	VERB
dpc-5172	59	13	in	in	ADP
dpc-5172	59	14	the	the	DET
dpc-5172	59	15	photoaged	photoage	VERB
dpc-5172	59	16	skin	skin	NOUN
dpc-5172	59	17	.	.	PUNCT
dpc-5172	60	1	in	in	ADP
dpc-5172	60	2	addition	addition	NOUN
dpc-5172	60	3	,	,	PUNCT
dpc-5172	60	4	individuals	individual	NOUN
dpc-5172	60	5	with	with	ADP
dpc-5172	60	6	the	the	DET
dpc-5172	60	7	hypertrophic	hypertrophic	ADJ
dpc-5172	60	8	photoaging	photoage	VERB
dpc-5172	60	9	phenotype	phenotype	NOUN
dpc-5172	60	10	,	,	PUNCT
dpc-5172	60	11	characterized	characterize	VERB
dpc-5172	60	12	by	by	ADP
dpc-5172	60	13	deep	deep	ADJ
dpc-5172	60	14	and	and	CCONJ
dpc-5172	60	15	pronounced	pronounced	ADJ
dpc-5172	60	16	wrinkles	wrinkle	NOUN
dpc-5172	60	17	,	,	PUNCT
dpc-5172	60	18	may	may	AUX
dpc-5172	60	19	benefit	benefit	VERB
dpc-5172	60	20	from	from	ADP
dpc-5172	60	21	injectables	injectable	NOUN
dpc-5172	60	22	such	such	ADJ
dpc-5172	60	23	as	as	ADP
dpc-5172	60	24	hyperdilute	hyperdilute	ADJ
dpc-5172	60	25	calcium	calcium	NOUN
dpc-5172	60	26	hydroxylapatite	hydroxylapatite	NOUN
dpc-5172	60	27	,	,	PUNCT
dpc-5172	60	28	which	which	PRON
dpc-5172	60	29	stimulates	stimulate	VERB
dpc-5172	60	30	collagen	collagen	NOUN
dpc-5172	60	31	remodeling	remodeling	NOUN
dpc-5172	60	32	and	and	CCONJ
dpc-5172	60	33	improves	improve	VERB
dpc-5172	60	34	overall	overall	ADJ
dpc-5172	60	35	skin	skin	NOUN
dpc-5172	60	36	texture	texture	NOUN
dpc-5172	61	1	[	[	X
dpc-5172	61	2	13,15	13,15	NUM
dpc-5172	61	3	-	-	SYM
dpc-5172	61	4	17	17	NUM
dpc-5172	61	5	]	]	PUNCT
dpc-5172	61	6	.	.	PUNCT
dpc-5172	62	1	these	these	DET
dpc-5172	62	2	therapies	therapy	NOUN
dpc-5172	62	3	are	be	AUX
dpc-5172	62	4	both	both	PRON
dpc-5172	62	5	cosmetic	cosmetic	ADJ
dpc-5172	62	6	enhancers	enhancer	NOUN
dpc-5172	62	7	and	and	CCONJ
dpc-5172	62	8	targeted	target	VERB
dpc-5172	62	9	treatments	treatment	NOUN
dpc-5172	62	10	for	for	ADP
dpc-5172	62	11	specific	specific	ADJ
dpc-5172	62	12	photoaging	photoaging	ADJ
dpc-5172	62	13	phenotypes	phenotype	NOUN
dpc-5172	62	14	.	.	PUNCT
dpc-5172	63	1	however	however	ADV
dpc-5172	63	2	,	,	PUNCT
dpc-5172	63	3	larger	large	ADJ
dpc-5172	63	4	clinical	clinical	ADJ
dpc-5172	63	5	trials	trial	NOUN
dpc-5172	63	6	are	be	AUX
dpc-5172	63	7	required	require	VERB
dpc-5172	63	8	to	to	PART
dpc-5172	63	9	validate	validate	VERB
dpc-5172	63	10	their	their	PRON
dpc-5172	63	11	efficacy	efficacy	NOUN
dpc-5172	63	12	and	and	CCONJ
dpc-5172	63	13	safety	safety	NOUN
dpc-5172	63	14	in	in	ADP
dpc-5172	63	15	treating	treat	VERB
dpc-5172	63	16	photoaging	photoaging	NOUN
dpc-5172	63	17	and	and	CCONJ
dpc-5172	63	18	to	to	PART
dpc-5172	63	19	clarify	clarify	VERB
dpc-5172	63	20	their	their	PRON
dpc-5172	63	21	role	role	NOUN
dpc-5172	63	22	in	in	ADP
dpc-5172	63	23	personalized	personalized	ADJ
dpc-5172	63	24	approaches	approach	NOUN
dpc-5172	63	25	to	to	ADP
dpc-5172	63	26	skin	skin	NOUN
dpc-5172	63	27	aging	aging	NOUN
dpc-5172	63	28	.	.	PUNCT
dpc-5172	64	1	large	large	ADJ
dpc-5172	64	2	-	-	PUNCT
dpc-5172	64	3	scale	scale	NOUN
dpc-5172	64	4	trials	trial	NOUN
dpc-5172	64	5	have	have	AUX
dpc-5172	64	6	demonstrated	demonstrate	VERB
dpc-5172	64	7	that	that	SCONJ
dpc-5172	64	8	topical	topical	ADJ
dpc-5172	64	9	tretinoin	tretinoin	NOUN
dpc-5172	64	10	is	be	AUX
dpc-5172	64	11	a	a	DET
dpc-5172	64	12	safe	safe	ADJ
dpc-5172	64	13	and	and	CCONJ
dpc-5172	64	14	effective	effective	ADJ
dpc-5172	64	15	means	mean	NOUN
dpc-5172	64	16	of	of	ADP
dpc-5172	64	17	reducing	reduce	VERB
dpc-5172	64	18	facial	facial	ADJ
dpc-5172	64	19	wrinkling	wrinkling	NOUN
dpc-5172	64	20	,	,	PUNCT
dpc-5172	64	21	mottled	mottled	ADJ
dpc-5172	64	22	hyperpigmentation	hyperpigmentation	NOUN
dpc-5172	64	23	,	,	PUNCT
dpc-5172	64	24	and	and	CCONJ
dpc-5172	64	25	skin	skin	NOUN
dpc-5172	64	26	roughness	roughness	NOUN
dpc-5172	64	27	.	.	PUNCT
dpc-5172	65	1	tretinoin	tretinoin	PROPN
dpc-5172	65	2	has	have	AUX
dpc-5172	65	3	also	also	ADV
dpc-5172	65	4	been	be	AUX
dpc-5172	65	5	reported	report	VERB
dpc-5172	65	6	to	to	PART
dpc-5172	65	7	partially	partially	ADV
dpc-5172	65	8	reverse	reverse	VERB
dpc-5172	65	9	skin	skin	NOUN
dpc-5172	65	10	photodamage	photodamage	NOUN
dpc-5172	65	11	[	[	X
dpc-5172	65	12	1,2,4	1,2,4	NUM
dpc-5172	65	13	-	-	SYM
dpc-5172	65	14	8	8	NUM
dpc-5172	65	15	]	]	PUNCT
dpc-5172	65	16	.	.	PUNCT
dpc-5172	66	1	although	although	SCONJ
dpc-5172	66	2	topical	topical	ADJ
dpc-5172	66	3	tretinoin	tretinoin	NOUN
dpc-5172	66	4	may	may	AUX
dpc-5172	66	5	have	have	VERB
dpc-5172	66	6	adverse	adverse	ADJ
dpc-5172	66	7	effects	effect	NOUN
dpc-5172	66	8	,	,	PUNCT
dpc-5172	66	9	it	it	PRON
dpc-5172	66	10	remains	remain	VERB
dpc-5172	66	11	the	the	DET
dpc-5172	66	12	most	most	ADV
dpc-5172	66	13	promising	promising	ADJ
dpc-5172	66	14	therapeutic	therapeutic	ADJ
dpc-5172	66	15	option	option	NOUN
dpc-5172	66	16	for	for	ADP
dpc-5172	66	17	photoaged	photoage	VERB
dpc-5172	66	18	skin	skin	NOUN
dpc-5172	66	19	.	.	PUNCT
dpc-5172	67	1	objective	objective	VERB
dpc-5172	67	2	the	the	DET
dpc-5172	67	3	present	present	ADJ
dpc-5172	67	4	systematic	systematic	ADJ
dpc-5172	67	5	review	review	NOUN
dpc-5172	67	6	and	and	CCONJ
dpc-5172	67	7	meta	meta	ADJ
dpc-5172	67	8	-	-	PUNCT
dpc-5172	67	9	analysis	analysis	NOUN
dpc-5172	67	10	evaluated	evaluate	VERB
dpc-5172	67	11	the	the	DET
dpc-5172	67	12	efficacy	efficacy	NOUN
dpc-5172	67	13	and	and	CCONJ
dpc-5172	67	14	adverse	adverse	ADJ
dpc-5172	67	15	effects	effect	NOUN
dpc-5172	67	16	of	of	ADP
dpc-5172	67	17	topical	topical	ADJ
dpc-5172	67	18	tretinoin	tretinoin	NOUN
dpc-5172	67	19	in	in	ADP
dpc-5172	67	20	the	the	DET
dpc-5172	67	21	treatment	treatment	NOUN
dpc-5172	67	22	of	of	ADP
dpc-5172	67	23	facial	facial	ADJ
dpc-5172	67	24	wrinkles	wrinkle	NOUN
dpc-5172	67	25	.	.	PUNCT
dpc-5172	68	1	methods	method	NOUN
dpc-5172	68	2	general	general	ADJ
dpc-5172	68	3	guidelines	guideline	VERB
dpc-5172	68	4	this	this	PRON
dpc-5172	68	5	meta	meta	ADJ
dpc-5172	68	6	-	-	PUNCT
dpc-5172	68	7	analysis	analysis	NOUN
dpc-5172	68	8	was	be	AUX
dpc-5172	68	9	conducted	conduct	VERB
dpc-5172	68	10	in	in	ADP
dpc-5172	68	11	accordance	accordance	NOUN
dpc-5172	68	12	with	with	ADP
dpc-5172	68	13	the	the	DET
dpc-5172	68	14	latest	late	ADJ
dpc-5172	68	15	version	version	NOUN
dpc-5172	68	16	of	of	ADP
dpc-5172	68	17	the	the	DET
dpc-5172	68	18	preferred	preferred	ADJ
dpc-5172	68	19	reporting	reporting	NOUN
dpc-5172	68	20	items	item	NOUN
dpc-5172	68	21	for	for	ADP
dpc-5172	68	22	systematic	systematic	ADJ
dpc-5172	68	23	reviews	review	NOUN
dpc-5172	68	24	and	and	CCONJ
dpc-5172	68	25	meta	meta	NOUN
dpc-5172	68	26	-	-	PUNCT
dpc-5172	68	27	analyses	analysis	NOUN
dpc-5172	68	28	(	(	PUNCT
dpc-5172	68	29	prisma	prisma	PROPN
dpc-5172	68	30	)	)	PUNCT
dpc-5172	68	31	2020	2020	NUM
dpc-5172	68	32	guidelines	guideline	NOUN
dpc-5172	68	33	review	review	VERB
dpc-5172	68	34	|	|	ADV
dpc-5172	68	35	dermatol	dermatol	ADJ
dpc-5172	68	36	pract	pract	NOUN
dpc-5172	68	37	concept	concept	NOUN
dpc-5172	68	38	.	.	PUNCT
dpc-5172	69	1	2025;15(4):5172	2025;15(4):5172	NOUN
dpc-5172	69	2	3	3	NUM
dpc-5172	69	3	[	[	X
dpc-5172	69	4	18	18	NUM
dpc-5172	69	5	]	]	PUNCT
dpc-5172	69	6	.	.	PUNCT
dpc-5172	70	1	the	the	DET
dpc-5172	70	2	prospero	prospero	NOUN
dpc-5172	70	3	registration	registration	NOUN
dpc-5172	70	4	number	number	NOUN
dpc-5172	70	5	of	of	ADP
dpc-5172	70	6	this	this	DET
dpc-5172	70	7	study	study	NOUN
dpc-5172	70	8	is	be	AUX
dpc-5172	70	9	crd42024511094	crd42024511094	VERB
dpc-5172	70	10	.	.	PUNCT
dpc-5172	71	1	search	search	NOUN
dpc-5172	71	2	strategy	strategy	NOUN
dpc-5172	71	3	and	and	CCONJ
dpc-5172	71	4	study	study	NOUN
dpc-5172	71	5	selection	selection	NOUN
dpc-5172	71	6	one	one	NUM
dpc-5172	71	7	investigator	investigator	NOUN
dpc-5172	71	8	(	(	PUNCT
dpc-5172	71	9	hh	hh	PROPN
dpc-5172	71	10	)	)	PUNCT
dpc-5172	71	11	conducted	conduct	VERB
dpc-5172	71	12	a	a	DET
dpc-5172	71	13	systematic	systematic	ADJ
dpc-5172	71	14	search	search	NOUN
dpc-5172	71	15	of	of	ADP
dpc-5172	71	16	three	three	NUM
dpc-5172	71	17	electronic	electronic	ADJ
dpc-5172	71	18	databases	database	NOUN
dpc-5172	71	19	,	,	PUNCT
dpc-5172	71	20	namely	namely	ADV
dpc-5172	71	21	,	,	PUNCT
dpc-5172	71	22	pubmed	pubmed	PROPN
dpc-5172	71	23	,	,	PUNCT
dpc-5172	71	24	embase	embase	NOUN
dpc-5172	71	25	,	,	PUNCT
dpc-5172	71	26	and	and	CCONJ
dpc-5172	71	27	cochrane	cochrane	PROPN
dpc-5172	71	28	central	central	NOUN
dpc-5172	71	29	,	,	PUNCT
dpc-5172	71	30	for	for	ADP
dpc-5172	71	31	randomized	randomized	ADJ
dpc-5172	71	32	controlled	control	VERB
dpc-5172	71	33	trials	trial	NOUN
dpc-5172	71	34	by	by	ADP
dpc-5172	71	35	using	use	VERB
dpc-5172	71	36	the	the	DET
dpc-5172	71	37	following	follow	VERB
dpc-5172	71	38	keywords	keyword	NOUN
dpc-5172	71	39	:	:	PUNCT
dpc-5172	71	40	(	(	PUNCT
dpc-5172	71	41	topical	topical	ADJ
dpc-5172	71	42	retinoid	retinoid	NOUN
dpc-5172	71	43	)	)	PUNCT
dpc-5172	71	44	or	or	CCONJ
dpc-5172	71	45	(	(	PUNCT
dpc-5172	71	46	retinoic	retinoic	ADJ
dpc-5172	71	47	acid	acid	NOUN
dpc-5172	71	48	)	)	PUNCT
dpc-5172	71	49	or	or	CCONJ
dpc-5172	71	50	(	(	PUNCT
dpc-5172	71	51	all	all	PRON
dpc-5172	71	52	-	-	PUNCT
dpc-5172	71	53	trans	trans	ADJ
dpc-5172	71	54	-	-	ADJ
dpc-5172	71	55	retinoic	retinoic	ADJ
dpc-5172	71	56	-	-	PUNCT
dpc-5172	71	57	acid	acid	NOUN
dpc-5172	71	58	)	)	PUNCT
dpc-5172	71	59	and	and	CCONJ
dpc-5172	71	60	(	(	PUNCT
dpc-5172	71	61	photoaging	photoage	VERB
dpc-5172	71	62	)	)	PUNCT
dpc-5172	71	63	or	or	CCONJ
dpc-5172	71	64	(	(	PUNCT
dpc-5172	71	65	photodamaged	photodamage	VERB
dpc-5172	71	66	)	)	PUNCT
dpc-5172	71	67	and	and	CCONJ
dpc-5172	71	68	(	(	PUNCT
dpc-5172	71	69	improvement	improvement	NOUN
dpc-5172	71	70	)	)	PUNCT
dpc-5172	71	71	and	and	CCONJ
dpc-5172	71	72	(	(	PUNCT
dpc-5172	71	73	wrinkle	wrinkle	NOUN
dpc-5172	71	74	)	)	PUNCT
dpc-5172	71	75	.	.	PUNCT
dpc-5172	72	1	the	the	DET
dpc-5172	72	2	search	search	NOUN
dpc-5172	72	3	included	include	VERB
dpc-5172	72	4	all	all	DET
dpc-5172	72	5	records	record	NOUN
dpc-5172	72	6	from	from	ADP
dpc-5172	72	7	the	the	DET
dpc-5172	72	8	inception	inception	NOUN
dpc-5172	72	9	of	of	ADP
dpc-5172	72	10	each	each	DET
dpc-5172	72	11	database	database	NOUN
dpc-5172	72	12	to	to	ADP
dpc-5172	72	13	16	16	NUM
dpc-5172	72	14	january	january	PROPN
dpc-5172	72	15	2024	2024	NUM
dpc-5172	72	16	.	.	PUNCT
dpc-5172	73	1	the	the	DET
dpc-5172	73	2	complete	complete	ADJ
dpc-5172	73	3	search	search	NOUN
dpc-5172	73	4	strategy	strategy	NOUN
dpc-5172	73	5	is	be	AUX
dpc-5172	73	6	outlined	outline	VERB
dpc-5172	73	7	in	in	ADP
dpc-5172	73	8	supplementary	supplementary	ADJ
dpc-5172	73	9	table	table	NOUN
dpc-5172	73	10	s1	s1	NOUN
dpc-5172	73	11	.	.	PUNCT
dpc-5172	74	1	all	all	DET
dpc-5172	74	2	identified	identify	VERB
dpc-5172	74	3	trials	trial	NOUN
dpc-5172	74	4	were	be	AUX
dpc-5172	74	5	recorded	record	VERB
dpc-5172	74	6	in	in	ADP
dpc-5172	74	7	an	an	DET
dpc-5172	74	8	excel	excel	NOUN
dpc-5172	74	9	spreadsheet	spreadsheet	NOUN
dpc-5172	74	10	for	for	ADP
dpc-5172	74	11	review	review	NOUN
dpc-5172	74	12	by	by	ADP
dpc-5172	74	13	a	a	DET
dpc-5172	74	14	second	second	ADJ
dpc-5172	74	15	investigator	investigator	NOUN
dpc-5172	74	16	(	(	PUNCT
dpc-5172	74	17	ltl	ltl	PROPN
dpc-5172	74	18	)	)	PUNCT
dpc-5172	74	19	.	.	PUNCT
dpc-5172	75	1	two	two	NUM
dpc-5172	75	2	investigators	investigator	NOUN
dpc-5172	75	3	(	(	PUNCT
dpc-5172	75	4	hh	hh	PROPN
dpc-5172	75	5	and	and	CCONJ
dpc-5172	75	6	ltl	ltl	PROPN
dpc-5172	75	7	)	)	PUNCT
dpc-5172	75	8	independently	independently	ADV
dpc-5172	75	9	screened	screen	VERB
dpc-5172	75	10	the	the	DET
dpc-5172	75	11	titles	title	NOUN
dpc-5172	75	12	and	and	CCONJ
dpc-5172	75	13	abstracts	abstract	NOUN
dpc-5172	75	14	of	of	ADP
dpc-5172	75	15	the	the	DET
dpc-5172	75	16	retrieved	retrieve	VERB
dpc-5172	75	17	studies	study	NOUN
dpc-5172	75	18	for	for	ADP
dpc-5172	75	19	eligibility	eligibility	NOUN
dpc-5172	75	20	,	,	PUNCT
dpc-5172	75	21	and	and	CCONJ
dpc-5172	75	22	any	any	DET
dpc-5172	75	23	discrepancies	discrepancy	NOUN
dpc-5172	75	24	were	be	AUX
dpc-5172	75	25	resolved	resolve	VERB
dpc-5172	75	26	through	through	ADP
dpc-5172	75	27	discussion	discussion	NOUN
dpc-5172	75	28	.	.	PUNCT
dpc-5172	76	1	only	only	ADV
dpc-5172	76	2	full	full	ADJ
dpc-5172	76	3	-	-	PUNCT
dpc-5172	76	4	text	text	NOUN
dpc-5172	76	5	articles	article	NOUN
dpc-5172	76	6	published	publish	VERB
dpc-5172	76	7	in	in	ADP
dpc-5172	76	8	english	english	PROPN
dpc-5172	76	9	were	be	AUX
dpc-5172	76	10	included	include	VERB
dpc-5172	76	11	.	.	PUNCT
dpc-5172	77	1	eligibility	eligibility	NOUN
dpc-5172	77	2	criteria	criterion	NOUN
dpc-5172	77	3	:	:	PUNCT
dpc-5172	77	4	inclusion	inclusion	NOUN
dpc-5172	77	5	and	and	CCONJ
dpc-5172	77	6	exclusion	exclusion	NOUN
dpc-5172	77	7	criteria	criterion	NOUN
dpc-5172	77	8	the	the	DET
dpc-5172	77	9	inclusion	inclusion	NOUN
dpc-5172	77	10	criteria	criterion	NOUN
dpc-5172	77	11	for	for	ADP
dpc-5172	77	12	the	the	DET
dpc-5172	77	13	trials	trial	NOUN
dpc-5172	77	14	were	be	AUX
dpc-5172	77	15	as	as	SCONJ
dpc-5172	77	16	follows	follow	VERB
dpc-5172	77	17	:	:	PUNCT
dpc-5172	77	18	i	i	NOUN
dpc-5172	77	19	)	)	PUNCT
dpc-5172	77	20	randomized	randomize	VERB
dpc-5172	77	21	,	,	PUNCT
dpc-5172	77	22	vehicle	vehicle	NOUN
dpc-5172	77	23	-	-	PUNCT
dpc-5172	77	24	controlled	control	VERB
dpc-5172	77	25	design	design	NOUN
dpc-5172	77	26	;	;	PUNCT
dpc-5172	77	27	ii	ii	X
dpc-5172	77	28	)	)	PUNCT
dpc-5172	77	29	use	use	NOUN
dpc-5172	77	30	of	of	ADP
dpc-5172	77	31	tretinoin	tretinoin	NOUN
dpc-5172	77	32	in	in	ADP
dpc-5172	77	33	a	a	DET
dpc-5172	77	34	single	single	ADJ
dpc-5172	77	35	formulation	formulation	NOUN
dpc-5172	77	36	with	with	ADP
dpc-5172	77	37	variations	variation	NOUN
dpc-5172	77	38	in	in	ADP
dpc-5172	77	39	dosage	dosage	NOUN
dpc-5172	77	40	,	,	PUNCT
dpc-5172	77	41	base	base	NOUN
dpc-5172	77	42	,	,	PUNCT
dpc-5172	77	43	and	and	CCONJ
dpc-5172	77	44	application	application	NOUN
dpc-5172	77	45	method	method	NOUN
dpc-5172	77	46	as	as	ADP
dpc-5172	77	47	the	the	DET
dpc-5172	77	48	primary	primary	ADJ
dpc-5172	77	49	treatment	treatment	NOUN
dpc-5172	77	50	for	for	ADP
dpc-5172	77	51	photoaging	photoaging	NOUN
dpc-5172	77	52	;	;	PUNCT
dpc-5172	77	53	iii	iii	X
dpc-5172	77	54	)	)	PUNCT
dpc-5172	77	55	evaluation	evaluation	NOUN
dpc-5172	77	56	of	of	ADP
dpc-5172	77	57	tretinoin	tretinoin	PROPN
dpc-5172	77	58	’s	’s	PART
dpc-5172	77	59	effects	effect	NOUN
dpc-5172	77	60	on	on	ADP
dpc-5172	77	61	facial	facial	ADJ
dpc-5172	77	62	skin	skin	NOUN
dpc-5172	77	63	wrinkles	wrinkle	NOUN
dpc-5172	77	64	(	(	PUNCT
dpc-5172	77	65	fine	fine	ADJ
dpc-5172	77	66	wrinkles	wrinkle	NOUN
dpc-5172	77	67	,	,	PUNCT
dpc-5172	77	68	coarse	coarse	ADJ
dpc-5172	77	69	wrinkles	wrinkle	NOUN
dpc-5172	77	70	,	,	PUNCT
dpc-5172	77	71	or	or	CCONJ
dpc-5172	77	72	both	both	PRON
dpc-5172	77	73	)	)	PUNCT
dpc-5172	77	74	,	,	PUNCT
dpc-5172	77	75	with	with	ADP
dpc-5172	77	76	results	result	NOUN
dpc-5172	77	77	reported	report	VERB
dpc-5172	77	78	as	as	ADP
dpc-5172	77	79	percentage	percentage	NOUN
dpc-5172	77	80	improvements	improvement	NOUN
dpc-5172	77	81	in	in	ADP
dpc-5172	77	82	wrinkle	wrinkle	NOUN
dpc-5172	77	83	appearance	appearance	NOUN
dpc-5172	77	84	;	;	PUNCT
dpc-5172	77	85	iv	iv	X
dpc-5172	77	86	)	)	PUNCT
dpc-5172	77	87	inclusion	inclusion	NOUN
dpc-5172	77	88	of	of	ADP
dpc-5172	77	89	participants	participant	NOUN
dpc-5172	77	90	aged	age	VERB
dpc-5172	77	91	18	18	NUM
dpc-5172	77	92	years	year	NOUN
dpc-5172	77	93	or	or	CCONJ
dpc-5172	77	94	older	old	ADJ
dpc-5172	77	95	with	with	ADP
dpc-5172	77	96	mild	mild	ADJ
dpc-5172	77	97	,	,	PUNCT
dpc-5172	77	98	moderate	moderate	ADJ
dpc-5172	77	99	,	,	PUNCT
dpc-5172	77	100	or	or	CCONJ
dpc-5172	77	101	severe	severe	ADJ
dpc-5172	77	102	skin	skin	NOUN
dpc-5172	77	103	photodamage	photodamage	NOUN
dpc-5172	77	104	.	.	PUNCT
dpc-5172	78	1	in	in	ADP
dpc-5172	78	2	trials	trial	NOUN
dpc-5172	78	3	that	that	PRON
dpc-5172	78	4	employed	employ	VERB
dpc-5172	78	5	multiple	multiple	ADJ
dpc-5172	78	6	treatment	treatment	NOUN
dpc-5172	78	7	dosages	dosage	NOUN
dpc-5172	78	8	,	,	PUNCT
dpc-5172	78	9	data	datum	NOUN
dpc-5172	78	10	extraction	extraction	NOUN
dpc-5172	78	11	was	be	AUX
dpc-5172	78	12	performed	perform	VERB
dpc-5172	78	13	separately	separately	ADV
dpc-5172	78	14	for	for	ADP
dpc-5172	78	15	each	each	DET
dpc-5172	78	16	dosage	dosage	NOUN
dpc-5172	78	17	to	to	PART
dpc-5172	78	18	ensure	ensure	VERB
dpc-5172	78	19	analytical	analytical	ADJ
dpc-5172	78	20	precision	precision	NOUN
dpc-5172	78	21	.	.	PUNCT
dpc-5172	79	1	percentage	percentage	NOUN
dpc-5172	79	2	improvements	improvement	NOUN
dpc-5172	79	3	in	in	ADP
dpc-5172	79	4	wrinkle	wrinkle	NOUN
dpc-5172	79	5	appearance	appearance	NOUN
dpc-5172	79	6	were	be	AUX
dpc-5172	79	7	individually	individually	ADV
dpc-5172	79	8	recorded	record	VERB
dpc-5172	79	9	for	for	ADP
dpc-5172	79	10	each	each	DET
dpc-5172	79	11	dosage	dosage	NOUN
dpc-5172	79	12	group	group	NOUN
dpc-5172	79	13	.	.	PUNCT
dpc-5172	80	1	when	when	SCONJ
dpc-5172	80	2	trials	trial	NOUN
dpc-5172	80	3	reported	report	VERB
dpc-5172	80	4	aggregated	aggregate	VERB
dpc-5172	80	5	outcomes	outcome	NOUN
dpc-5172	80	6	without	without	ADP
dpc-5172	80	7	providing	provide	VERB
dpc-5172	80	8	dosage	dosage	NOUN
dpc-5172	80	9	-	-	PUNCT
dpc-5172	80	10	specific	specific	ADJ
dpc-5172	80	11	data	datum	NOUN
dpc-5172	80	12	,	,	PUNCT
dpc-5172	80	13	the	the	DET
dpc-5172	80	14	corresponding	corresponding	ADJ
dpc-5172	80	15	authors	author	NOUN
dpc-5172	80	16	were	be	AUX
dpc-5172	80	17	contacted	contact	VERB
dpc-5172	80	18	to	to	PART
dpc-5172	80	19	obtain	obtain	VERB
dpc-5172	80	20	detailed	detailed	ADJ
dpc-5172	80	21	information	information	NOUN
dpc-5172	80	22	.	.	PUNCT
dpc-5172	81	1	if	if	SCONJ
dpc-5172	81	2	these	these	DET
dpc-5172	81	3	data	datum	NOUN
dpc-5172	81	4	were	be	AUX
dpc-5172	81	5	unavailable	unavailable	ADJ
dpc-5172	81	6	,	,	PUNCT
dpc-5172	81	7	results	result	NOUN
dpc-5172	81	8	were	be	AUX
dpc-5172	81	9	included	include	VERB
dpc-5172	81	10	in	in	ADP
dpc-5172	81	11	the	the	DET
dpc-5172	81	12	meta	meta	NOUN
dpc-5172	81	13	-	-	PUNCT
dpc-5172	81	14	analysis	analysis	NOUN
dpc-5172	81	15	on	on	ADP
dpc-5172	81	16	the	the	DET
dpc-5172	81	17	basis	basis	NOUN
dpc-5172	81	18	of	of	ADP
dpc-5172	81	19	the	the	DET
dpc-5172	81	20	most	most	ADV
dpc-5172	81	21	relevant	relevant	ADJ
dpc-5172	81	22	available	available	ADJ
dpc-5172	81	23	information	information	NOUN
dpc-5172	81	24	,	,	PUNCT
dpc-5172	81	25	and	and	CCONJ
dpc-5172	81	26	sensitivity	sensitivity	NOUN
dpc-5172	81	27	analyses	analysis	NOUN
dpc-5172	81	28	were	be	AUX
dpc-5172	81	29	conducted	conduct	VERB
dpc-5172	81	30	to	to	PART
dpc-5172	81	31	evaluate	evaluate	VERB
dpc-5172	81	32	the	the	DET
dpc-5172	81	33	potential	potential	ADJ
dpc-5172	81	34	impact	impact	NOUN
dpc-5172	81	35	of	of	ADP
dpc-5172	81	36	data	datum	NOUN
dpc-5172	81	37	inconsistencies	inconsistency	NOUN
dpc-5172	81	38	.	.	PUNCT
dpc-5172	82	1	the	the	DET
dpc-5172	82	2	following	follow	VERB
dpc-5172	82	3	types	type	NOUN
dpc-5172	82	4	of	of	ADP
dpc-5172	82	5	studies	study	NOUN
dpc-5172	82	6	were	be	AUX
dpc-5172	82	7	excluded	exclude	VERB
dpc-5172	82	8	:	:	PUNCT
dpc-5172	82	9	i	i	PRON
dpc-5172	82	10	)	)	PUNCT
dpc-5172	82	11	nonrandomized	nonrandomize	VERB
dpc-5172	82	12	controlled	control	VERB
dpc-5172	82	13	trials	trial	NOUN
dpc-5172	82	14	;	;	PUNCT
dpc-5172	82	15	ii	ii	X
dpc-5172	82	16	)	)	PUNCT
dpc-5172	82	17	trials	trial	NOUN
dpc-5172	82	18	without	without	ADP
dpc-5172	82	19	a	a	DET
dpc-5172	82	20	vehicle	vehicle	NOUN
dpc-5172	82	21	control	control	NOUN
dpc-5172	82	22	;	;	PUNCT
dpc-5172	82	23	iii	iii	X
dpc-5172	82	24	)	)	PUNCT
dpc-5172	82	25	studies	study	NOUN
dpc-5172	82	26	assessing	assess	VERB
dpc-5172	82	27	photoaging	photoage	VERB
dpc-5172	82	28	outcomes	outcome	NOUN
dpc-5172	82	29	other	other	ADJ
dpc-5172	82	30	than	than	ADP
dpc-5172	82	31	facial	facial	ADJ
dpc-5172	82	32	wrinkles	wrinkle	NOUN
dpc-5172	82	33	;	;	PUNCT
dpc-5172	82	34	iv	iv	X
dpc-5172	82	35	)	)	PUNCT
dpc-5172	82	36	trials	trial	NOUN
dpc-5172	82	37	using	use	VERB
dpc-5172	82	38	treatment	treatment	NOUN
dpc-5172	82	39	regimens	regimen	NOUN
dpc-5172	82	40	other	other	ADJ
dpc-5172	82	41	than	than	ADP
dpc-5172	82	42	topical	topical	ADJ
dpc-5172	82	43	tretinoin	tretinoin	NOUN
dpc-5172	82	44	;	;	PUNCT
dpc-5172	82	45	v	v	X
dpc-5172	82	46	)	)	PUNCT
dpc-5172	82	47	studies	study	NOUN
dpc-5172	82	48	lacking	lack	VERB
dpc-5172	82	49	data	datum	NOUN
dpc-5172	82	50	on	on	ADP
dpc-5172	82	51	percentage	percentage	NOUN
dpc-5172	82	52	improvements	improvement	NOUN
dpc-5172	82	53	in	in	ADP
dpc-5172	82	54	wrinkle	wrinkle	NOUN
dpc-5172	82	55	appearance	appearance	NOUN
dpc-5172	82	56	following	follow	VERB
dpc-5172	82	57	therapy	therapy	NOUN
dpc-5172	82	58	.	.	PUNCT
dpc-5172	83	1	detailed	detailed	ADJ
dpc-5172	83	2	reasons	reason	NOUN
dpc-5172	83	3	for	for	ADP
dpc-5172	83	4	article	article	NOUN
dpc-5172	83	5	exclusion	exclusion	NOUN
dpc-5172	83	6	are	be	AUX
dpc-5172	83	7	provided	provide	VERB
dpc-5172	83	8	in	in	ADP
dpc-5172	83	9	table	table	NOUN
dpc-5172	83	10	s2	s2	PROPN
dpc-5172	83	11	.	.	PUNCT
dpc-5172	84	1	outcomes	outcome	NOUN
dpc-5172	84	2	and	and	CCONJ
dpc-5172	84	3	data	datum	NOUN
dpc-5172	84	4	extraction	extraction	NOUN
dpc-5172	84	5	the	the	DET
dpc-5172	84	6	first	first	ADJ
dpc-5172	84	7	reviewer	reviewer	NOUN
dpc-5172	84	8	(	(	PUNCT
dpc-5172	84	9	hh	hh	PROPN
dpc-5172	84	10	)	)	PUNCT
dpc-5172	84	11	conducted	conduct	VERB
dpc-5172	84	12	the	the	DET
dpc-5172	84	13	initial	initial	ADJ
dpc-5172	84	14	data	data	NOUN
dpc-5172	84	15	extraction	extraction	NOUN
dpc-5172	84	16	on	on	ADP
dpc-5172	84	17	the	the	DET
dpc-5172	84	18	basis	basis	NOUN
dpc-5172	84	19	of	of	ADP
dpc-5172	84	20	the	the	DET
dpc-5172	84	21	inclusion	inclusion	NOUN
dpc-5172	84	22	criteria	criterion	NOUN
dpc-5172	84	23	and	and	CCONJ
dpc-5172	84	24	recorded	record	VERB
dpc-5172	84	25	the	the	DET
dpc-5172	84	26	results	result	NOUN
dpc-5172	84	27	in	in	ADP
dpc-5172	84	28	excel	excel	NOUN
dpc-5172	84	29	spreadsheets	spreadsheet	NOUN
dpc-5172	84	30	and	and	CCONJ
dpc-5172	84	31	tables	table	NOUN
dpc-5172	84	32	.	.	PUNCT
dpc-5172	85	1	the	the	DET
dpc-5172	85	2	second	second	ADJ
dpc-5172	85	3	reviewer	reviewer	NOUN
dpc-5172	85	4	(	(	PUNCT
dpc-5172	85	5	ltl	ltl	PROPN
dpc-5172	85	6	)	)	PUNCT
dpc-5172	85	7	independently	independently	ADV
dpc-5172	85	8	extracted	extract	VERB
dpc-5172	85	9	the	the	DET
dpc-5172	85	10	data	datum	NOUN
dpc-5172	85	11	and	and	CCONJ
dpc-5172	85	12	compared	compare	VERB
dpc-5172	85	13	their	their	PRON
dpc-5172	85	14	results	result	NOUN
dpc-5172	85	15	with	with	ADP
dpc-5172	85	16	those	those	PRON
dpc-5172	85	17	of	of	ADP
dpc-5172	85	18	the	the	DET
dpc-5172	85	19	first	first	ADJ
dpc-5172	85	20	reviewer	reviewer	NOUN
dpc-5172	85	21	,	,	PUNCT
dpc-5172	85	22	and	and	CCONJ
dpc-5172	85	23	any	any	DET
dpc-5172	85	24	discrepancies	discrepancy	NOUN
dpc-5172	85	25	were	be	AUX
dpc-5172	85	26	resolved	resolve	VERB
dpc-5172	85	27	through	through	ADP
dpc-5172	85	28	discussion	discussion	NOUN
dpc-5172	85	29	.	.	PUNCT
dpc-5172	86	1	extracted	extract	VERB
dpc-5172	86	2	data	datum	NOUN
dpc-5172	86	3	included	include	VERB
dpc-5172	86	4	study	study	NOUN
dpc-5172	86	5	design	design	NOUN
dpc-5172	86	6	,	,	PUNCT
dpc-5172	86	7	baseline	baseline	PROPN
dpc-5172	86	8	demographics	demographic	NOUN
dpc-5172	86	9	,	,	PUNCT
dpc-5172	86	10	tretinoin	tretinoin	PROPN
dpc-5172	86	11	intervention	intervention	NOUN
dpc-5172	86	12	details	detail	NOUN
dpc-5172	86	13	,	,	PUNCT
dpc-5172	86	14	treatment	treatment	NOUN
dpc-5172	86	15	duration	duration	NOUN
dpc-5172	86	16	,	,	PUNCT
dpc-5172	86	17	and	and	CCONJ
dpc-5172	86	18	primary	primary	ADJ
dpc-5172	86	19	,	,	PUNCT
dpc-5172	86	20	secondary	secondary	ADJ
dpc-5172	86	21	,	,	PUNCT
dpc-5172	86	22	and	and	CCONJ
dpc-5172	86	23	tertiary	tertiary	ADJ
dpc-5172	86	24	outcome	outcome	NOUN
dpc-5172	86	25	values	value	NOUN
dpc-5172	86	26	.	.	PUNCT
dpc-5172	87	1	the	the	DET
dpc-5172	87	2	primary	primary	ADJ
dpc-5172	87	3	outcome	outcome	NOUN
dpc-5172	87	4	of	of	ADP
dpc-5172	87	5	interest	interest	NOUN
dpc-5172	87	6	was	be	AUX
dpc-5172	87	7	the	the	DET
dpc-5172	87	8	percentage	percentage	NOUN
dpc-5172	87	9	improvement	improvement	NOUN
dpc-5172	87	10	in	in	ADP
dpc-5172	87	11	wrinkle	wrinkle	NOUN
dpc-5172	87	12	appearance	appearance	NOUN
dpc-5172	87	13	(	(	PUNCT
dpc-5172	87	14	fine	fine	ADJ
dpc-5172	87	15	or	or	CCONJ
dpc-5172	87	16	coarse	coarse	ADJ
dpc-5172	87	17	)	)	PUNCT
dpc-5172	87	18	from	from	ADP
dpc-5172	87	19	baseline	baseline	NOUN
dpc-5172	87	20	to	to	ADP
dpc-5172	87	21	the	the	DET
dpc-5172	87	22	endpoint	endpoint	NOUN
dpc-5172	87	23	,	,	PUNCT
dpc-5172	87	24	as	as	SCONJ
dpc-5172	87	25	assessed	assess	VERB
dpc-5172	87	26	by	by	ADP
dpc-5172	87	27	professional	professional	ADJ
dpc-5172	87	28	investigators	investigator	NOUN
dpc-5172	87	29	in	in	ADP
dpc-5172	87	30	the	the	DET
dpc-5172	87	31	included	include	VERB
dpc-5172	87	32	trials	trial	NOUN
dpc-5172	87	33	.	.	PUNCT
dpc-5172	88	1	data	datum	NOUN
dpc-5172	88	2	were	be	AUX
dpc-5172	88	3	extracted	extract	VERB
dpc-5172	88	4	separately	separately	ADV
dpc-5172	88	5	for	for	ADP
dpc-5172	88	6	each	each	DET
dpc-5172	88	7	wrinkle	wrinkle	NOUN
dpc-5172	88	8	type	type	NOUN
dpc-5172	88	9	,	,	PUNCT
dpc-5172	88	10	and	and	CCONJ
dpc-5172	88	11	percentages	percentage	NOUN
dpc-5172	88	12	were	be	AUX
dpc-5172	88	13	manually	manually	ADV
dpc-5172	88	14	calculated	calculate	VERB
dpc-5172	88	15	when	when	SCONJ
dpc-5172	88	16	only	only	ADV
dpc-5172	88	17	the	the	DET
dpc-5172	88	18	number	number	NOUN
dpc-5172	88	19	of	of	ADP
dpc-5172	88	20	patients	patient	NOUN
dpc-5172	88	21	exhibiting	exhibit	VERB
dpc-5172	88	22	improvement	improvement	NOUN
dpc-5172	88	23	was	be	AUX
dpc-5172	88	24	reported	report	VERB
dpc-5172	88	25	[	[	X
dpc-5172	88	26	1,6	1,6	NUM
dpc-5172	88	27	]	]	PUNCT
dpc-5172	88	28	.	.	PUNCT
dpc-5172	89	1	all	all	DET
dpc-5172	89	2	relevant	relevant	ADJ
dpc-5172	89	3	data	datum	NOUN
dpc-5172	89	4	were	be	AUX
dpc-5172	89	5	included	include	VERB
dpc-5172	89	6	from	from	ADP
dpc-5172	89	7	trials	trial	NOUN
dpc-5172	89	8	that	that	PRON
dpc-5172	89	9	reported	report	VERB
dpc-5172	89	10	multiple	multiple	ADJ
dpc-5172	89	11	results	result	NOUN
dpc-5172	89	12	either	either	CCONJ
dpc-5172	89	13	because	because	SCONJ
dpc-5172	89	14	multiple	multiple	ADJ
dpc-5172	89	15	treatment	treatment	NOUN
dpc-5172	89	16	dosages	dosage	NOUN
dpc-5172	89	17	were	be	AUX
dpc-5172	89	18	used	use	VERB
dpc-5172	89	19	[	[	X
dpc-5172	89	20	5,19	5,19	X
dpc-5172	89	21	]	]	PUNCT
dpc-5172	89	22	or	or	CCONJ
dpc-5172	89	23	because	because	SCONJ
dpc-5172	89	24	the	the	DET
dpc-5172	89	25	study	study	NOUN
dpc-5172	89	26	was	be	AUX
dpc-5172	89	27	conducted	conduct	VERB
dpc-5172	89	28	at	at	ADP
dpc-5172	89	29	multiple	multiple	ADJ
dpc-5172	89	30	centers	center	NOUN
dpc-5172	89	31	[	[	X
dpc-5172	89	32	2	2	NUM
dpc-5172	89	33	]	]	PUNCT
dpc-5172	89	34	.	.	PUNCT
dpc-5172	90	1	if	if	SCONJ
dpc-5172	90	2	data	datum	NOUN
dpc-5172	90	3	were	be	AUX
dpc-5172	90	4	missing	miss	VERB
dpc-5172	90	5	in	in	ADP
dpc-5172	90	6	a	a	DET
dpc-5172	90	7	study	study	NOUN
dpc-5172	90	8	(	(	PUNCT
dpc-5172	90	9	e.g.	e.g.	ADV
dpc-5172	90	10	,	,	PUNCT
dpc-5172	90	11	when	when	SCONJ
dpc-5172	90	12	the	the	DET
dpc-5172	90	13	effect	effect	NOUN
dpc-5172	90	14	on	on	ADP
dpc-5172	90	15	coarse	coarse	ADJ
dpc-5172	90	16	wrinkling	wrinkling	NOUN
dpc-5172	90	17	was	be	AUX
dpc-5172	90	18	reported	report	VERB
dpc-5172	90	19	as	as	ADP
dpc-5172	90	20	nonsignificant	nonsignificant	ADJ
dpc-5172	90	21	,	,	PUNCT
dpc-5172	90	22	but	but	CCONJ
dpc-5172	90	23	no	no	DET
dpc-5172	90	24	supporting	support	VERB
dpc-5172	90	25	data	datum	NOUN
dpc-5172	90	26	were	be	AUX
dpc-5172	90	27	provided	provide	VERB
dpc-5172	90	28	,	,	PUNCT
dpc-5172	90	29	as	as	ADP
dpc-5172	90	30	in	in	ADP
dpc-5172	90	31	weinstein	weinstein	PROPN
dpc-5172	90	32	et	et	PROPN
dpc-5172	90	33	al	al	PROPN
dpc-5172	90	34	.	.	PUNCT
dpc-5172	91	1	[	[	X
dpc-5172	91	2	19	19	NUM
dpc-5172	91	3	]	]	NUM
dpc-5172	91	4	)	)	PUNCT
dpc-5172	91	5	,	,	PUNCT
dpc-5172	91	6	the	the	DET
dpc-5172	91	7	corresponding	corresponding	ADJ
dpc-5172	91	8	author	author	NOUN
dpc-5172	91	9	was	be	AUX
dpc-5172	91	10	contacted	contact	VERB
dpc-5172	91	11	through	through	ADP
dpc-5172	91	12	email	email	NOUN
dpc-5172	91	13	to	to	PART
dpc-5172	91	14	obtain	obtain	VERB
dpc-5172	91	15	the	the	DET
dpc-5172	91	16	original	original	ADJ
dpc-5172	91	17	data	datum	NOUN
dpc-5172	91	18	.	.	PUNCT
dpc-5172	92	1	the	the	DET
dpc-5172	92	2	secondary	secondary	ADJ
dpc-5172	92	3	outcome	outcome	NOUN
dpc-5172	92	4	of	of	ADP
dpc-5172	92	5	interest	interest	NOUN
dpc-5172	92	6	was	be	AUX
dpc-5172	92	7	the	the	DET
dpc-5172	92	8	overall	overall	ADJ
dpc-5172	92	9	improvement	improvement	NOUN
dpc-5172	92	10	in	in	ADP
dpc-5172	92	11	facial	facial	ADJ
dpc-5172	92	12	wrinkling	wrinkling	NOUN
dpc-5172	92	13	caused	cause	VERB
dpc-5172	92	14	by	by	ADP
dpc-5172	92	15	photodamage	photodamage	NOUN
dpc-5172	92	16	,	,	PUNCT
dpc-5172	92	17	as	as	SCONJ
dpc-5172	92	18	self	self	NOUN
dpc-5172	92	19	-	-	PUNCT
dpc-5172	92	20	assessed	assess	VERB
dpc-5172	92	21	by	by	ADP
dpc-5172	92	22	participants	participant	NOUN
dpc-5172	92	23	.	.	PUNCT
dpc-5172	93	1	the	the	DET
dpc-5172	93	2	primary	primary	ADJ
dpc-5172	93	3	outcome	outcome	NOUN
dpc-5172	93	4	was	be	AUX
dpc-5172	93	5	objective	objective	ADJ
dpc-5172	93	6	,	,	PUNCT
dpc-5172	93	7	whereas	whereas	SCONJ
dpc-5172	93	8	the	the	DET
dpc-5172	93	9	secondary	secondary	ADJ
dpc-5172	93	10	outcome	outcome	NOUN
dpc-5172	93	11	was	be	AUX
dpc-5172	93	12	subjective	subjective	ADJ
dpc-5172	93	13	.	.	PUNCT
dpc-5172	94	1	percentage	percentage	NOUN
dpc-5172	94	2	improvements	improvement	NOUN
dpc-5172	94	3	for	for	ADP
dpc-5172	94	4	both	both	DET
dpc-5172	94	5	outcomes	outcome	NOUN
dpc-5172	94	6	were	be	AUX
dpc-5172	94	7	extracted	extract	VERB
dpc-5172	94	8	and	and	CCONJ
dpc-5172	94	9	are	be	AUX
dpc-5172	94	10	presented	present	VERB
dpc-5172	94	11	in	in	ADP
dpc-5172	94	12	table	table	NOUN
dpc-5172	94	13	s3	s3	PROPN
dpc-5172	94	14	.	.	PUNCT
dpc-5172	95	1	the	the	DET
dpc-5172	95	2	tertiary	tertiary	ADJ
dpc-5172	95	3	outcome	outcome	NOUN
dpc-5172	95	4	involved	involve	VERB
dpc-5172	95	5	adverse	adverse	ADJ
dpc-5172	95	6	events	event	NOUN
dpc-5172	95	7	,	,	PUNCT
dpc-5172	95	8	and	and	CCONJ
dpc-5172	95	9	event	event	NOUN
dpc-5172	95	10	rates	rate	NOUN
dpc-5172	95	11	were	be	AUX
dpc-5172	95	12	calculated	calculate	VERB
dpc-5172	95	13	and	and	CCONJ
dpc-5172	95	14	are	be	AUX
dpc-5172	95	15	reported	report	VERB
dpc-5172	95	16	using	use	VERB
dpc-5172	95	17	odds	odd	NOUN
dpc-5172	95	18	ratios	ratio	NOUN
dpc-5172	95	19	(	(	PUNCT
dpc-5172	95	20	or	or	CCONJ
dpc-5172	95	21	)	)	PUNCT
dpc-5172	95	22	.	.	PUNCT
dpc-5172	96	1	study	study	NOUN
dpc-5172	96	2	quality	quality	NOUN
dpc-5172	96	3	and	and	CCONJ
dpc-5172	96	4	risk	risk	NOUN
dpc-5172	96	5	of	of	ADP
dpc-5172	96	6	bias	bias	NOUN
dpc-5172	96	7	assessments	assessment	VERB
dpc-5172	96	8	the	the	DET
dpc-5172	96	9	quality	quality	NOUN
dpc-5172	96	10	of	of	ADP
dpc-5172	96	11	the	the	DET
dpc-5172	96	12	included	include	VERB
dpc-5172	96	13	studies	study	NOUN
dpc-5172	96	14	was	be	AUX
dpc-5172	96	15	independently	independently	ADV
dpc-5172	96	16	assessed	assess	VERB
dpc-5172	96	17	by	by	ADP
dpc-5172	96	18	two	two	NUM
dpc-5172	96	19	reviewers	reviewer	NOUN
dpc-5172	96	20	(	(	PUNCT
dpc-5172	96	21	hh	hh	PROPN
dpc-5172	96	22	and	and	CCONJ
dpc-5172	96	23	ltl	ltl	PROPN
dpc-5172	96	24	)	)	PUNCT
dpc-5172	96	25	by	by	ADP
dpc-5172	96	26	using	use	VERB
dpc-5172	96	27	the	the	DET
dpc-5172	96	28	cochrane	cochrane	NOUN
dpc-5172	96	29	risk	risk	NOUN
dpc-5172	96	30	of	of	ADP
dpc-5172	96	31	bias	bias	NOUN
dpc-5172	96	32	tool	tool	NOUN
dpc-5172	96	33	for	for	ADP
dpc-5172	96	34	randomized	randomized	ADJ
dpc-5172	96	35	trials	trial	NOUN
dpc-5172	96	36	(	(	PUNCT
dpc-5172	96	37	version	version	NOUN
dpc-5172	96	38	2	2	NUM
dpc-5172	96	39	,	,	PUNCT
dpc-5172	96	40	rob	rob	PROPN
dpc-5172	96	41	2	2	NUM
dpc-5172	96	42	,	,	PUNCT
dpc-5172	96	43	london	london	PROPN
dpc-5172	96	44	,	,	PUNCT
dpc-5172	96	45	uk	uk	PROPN
dpc-5172	96	46	)	)	PUNCT
dpc-5172	96	47	.	.	PUNCT
dpc-5172	97	1	six	six	NUM
dpc-5172	97	2	domains	domain	NOUN
dpc-5172	97	3	of	of	ADP
dpc-5172	97	4	bias	bias	NOUN
dpc-5172	97	5	were	be	AUX
dpc-5172	97	6	evaluated	evaluate	VERB
dpc-5172	97	7	:	:	PUNCT
dpc-5172	97	8	i	i	PRON
dpc-5172	97	9	)	)	PUNCT
dpc-5172	97	10	randomization	randomization	NOUN
dpc-5172	97	11	process	process	NOUN
dpc-5172	97	12	;	;	PUNCT
dpc-5172	97	13	ii	ii	X
dpc-5172	97	14	)	)	PUNCT
dpc-5172	97	15	intervention	intervention	NOUN
dpc-5172	97	16	adherence	adherence	NOUN
dpc-5172	97	17	;	;	PUNCT
dpc-5172	97	18	iii	iii	X
dpc-5172	97	19	)	)	PUNCT
dpc-5172	97	20	missing	miss	VERB
dpc-5172	97	21	outcome	outcome	NOUN
dpc-5172	97	22	data	datum	NOUN
dpc-5172	97	23	;	;	PUNCT
dpc-5172	97	24	iv	iv	X
dpc-5172	97	25	)	)	PUNCT
dpc-5172	97	26	outcome	outcome	NOUN
dpc-5172	97	27	measurement	measurement	NOUN
dpc-5172	97	28	;	;	PUNCT
dpc-5172	97	29	v	v	X
dpc-5172	97	30	)	)	PUNCT
dpc-5172	97	31	selective	selective	ADJ
dpc-5172	97	32	reporting	reporting	NOUN
dpc-5172	97	33	;	;	PUNCT
dpc-5172	97	34	vi	vi	X
dpc-5172	97	35	)	)	PUNCT
dpc-5172	97	36	overall	overall	ADJ
dpc-5172	97	37	risk	risk	NOUN
dpc-5172	97	38	of	of	ADP
dpc-5172	97	39	bias	bias	NOUN
dpc-5172	97	40	[	[	X
dpc-5172	97	41	20	20	NUM
dpc-5172	97	42	]	]	PUNCT
dpc-5172	97	43	.	.	PUNCT
dpc-5172	98	1	each	each	DET
dpc-5172	98	2	domain	domain	NOUN
dpc-5172	98	3	was	be	AUX
dpc-5172	98	4	rated	rate	VERB
dpc-5172	98	5	as	as	ADP
dpc-5172	98	6	low	low	ADJ
dpc-5172	98	7	risk	risk	NOUN
dpc-5172	98	8	,	,	PUNCT
dpc-5172	98	9	some	some	DET
dpc-5172	98	10	concerns	concern	NOUN
dpc-5172	98	11	,	,	PUNCT
dpc-5172	98	12	or	or	CCONJ
dpc-5172	98	13	high	high	ADJ
dpc-5172	98	14	risk	risk	NOUN
dpc-5172	98	15	.	.	PUNCT
dpc-5172	99	1	on	on	ADP
dpc-5172	99	2	the	the	DET
dpc-5172	99	3	basis	basis	NOUN
dpc-5172	99	4	of	of	ADP
dpc-5172	99	5	these	these	DET
dpc-5172	99	6	ratings	rating	NOUN
dpc-5172	99	7	,	,	PUNCT
dpc-5172	99	8	each	each	DET
dpc-5172	99	9	trial	trial	NOUN
dpc-5172	99	10	was	be	AUX
dpc-5172	99	11	categorized	categorize	VERB
dpc-5172	99	12	as	as	ADP
dpc-5172	99	13	having	have	VERB
dpc-5172	99	14	a	a	DET
dpc-5172	99	15	low	low	ADJ
dpc-5172	99	16	risk	risk	NOUN
dpc-5172	99	17	of	of	ADP
dpc-5172	99	18	bias	bias	NOUN
dpc-5172	99	19	,	,	PUNCT
dpc-5172	99	20	some	some	DET
dpc-5172	99	21	concerns	concern	NOUN
dpc-5172	99	22	,	,	PUNCT
dpc-5172	99	23	or	or	CCONJ
dpc-5172	99	24	a	a	DET
dpc-5172	99	25	high	high	ADJ
dpc-5172	99	26	risk	risk	NOUN
dpc-5172	99	27	of	of	ADP
dpc-5172	99	28	bias	bias	NOUN
dpc-5172	99	29	.	.	PUNCT
dpc-5172	100	1	any	any	DET
dpc-5172	100	2	disagreement	disagreement	NOUN
dpc-5172	100	3	between	between	ADP
dpc-5172	100	4	reviewers	reviewer	NOUN
dpc-5172	100	5	was	be	AUX
dpc-5172	100	6	resolved	resolve	VERB
dpc-5172	100	7	through	through	ADP
dpc-5172	100	8	discussion	discussion	NOUN
dpc-5172	100	9	and	and	CCONJ
dpc-5172	100	10	until	until	SCONJ
dpc-5172	100	11	a	a	DET
dpc-5172	100	12	consensus	consensus	NOUN
dpc-5172	100	13	was	be	AUX
dpc-5172	100	14	reached	reach	VERB
dpc-5172	100	15	.	.	PUNCT
dpc-5172	101	1	statistical	statistical	ADJ
dpc-5172	101	2	analysis	analysis	NOUN
dpc-5172	101	3	a	a	DET
dpc-5172	101	4	random	random	ADJ
dpc-5172	101	5	effects	effect	NOUN
dpc-5172	101	6	model	model	NOUN
dpc-5172	101	7	was	be	AUX
dpc-5172	101	8	used	use	VERB
dpc-5172	101	9	to	to	PART
dpc-5172	101	10	analyze	analyze	VERB
dpc-5172	101	11	the	the	DET
dpc-5172	101	12	data	datum	NOUN
dpc-5172	101	13	through	through	ADP
dpc-5172	101	14	comprehensive	comprehensive	ADJ
dpc-5172	101	15	meta	meta	ADJ
dpc-5172	101	16	-	-	PUNCT
dpc-5172	101	17	analysis	analysis	NOUN
dpc-5172	101	18	software	software	NOUN
dpc-5172	101	19	(	(	PUNCT
dpc-5172	101	20	version	version	NOUN
dpc-5172	101	21	4	4	NUM
dpc-5172	101	22	,	,	PUNCT
dpc-5172	101	23	biostat	biostat	ADJ
dpc-5172	101	24	,	,	PUNCT
dpc-5172	101	25	englewood	englewood	PROPN
dpc-5172	101	26	,	,	PUNCT
dpc-5172	101	27	nj	nj	PROPN
dpc-5172	101	28	,	,	PUNCT
dpc-5172	101	29	usa	usa	PROPN
dpc-5172	101	30	)	)	PUNCT
dpc-5172	101	31	.	.	PUNCT
dpc-5172	102	1	a	a	DET
dpc-5172	102	2	two	two	NUM
dpc-5172	102	3	-	-	PUNCT
dpc-5172	102	4	tailed	tail	VERB
dpc-5172	102	5	p	p	NOUN
dpc-5172	102	6	-	-	PUNCT
dpc-5172	102	7	value	value	NOUN
dpc-5172	102	8	of	of	ADP
dpc-5172	102	9	<	<	NOUN
dpc-5172	102	10	0.05	0.05	NUM
dpc-5172	102	11	was	be	AUX
dpc-5172	102	12	considered	consider	VERB
dpc-5172	102	13	significant	significant	ADJ
dpc-5172	102	14	.	.	PUNCT
dpc-5172	103	1	4	4	NUM
dpc-5172	103	2	review	review	NOUN
dpc-5172	103	3	|	|	ADV
dpc-5172	103	4	dermatol	dermatol	ADJ
dpc-5172	103	5	pract	pract	NOUN
dpc-5172	103	6	concept	concept	NOUN
dpc-5172	103	7	.	.	PUNCT
dpc-5172	104	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	104	2	primary	primary	ADJ
dpc-5172	104	3	outcome	outcome	NOUN
dpc-5172	104	4	:	:	PUNCT
dpc-5172	104	5	improvement	improvement	NOUN
dpc-5172	104	6	in	in	ADP
dpc-5172	104	7	fine	fine	ADJ
dpc-5172	104	8	facial	facial	ADJ
dpc-5172	104	9	wrinkles	wrinkle	NOUN
dpc-5172	104	10	after	after	ADP
dpc-5172	104	11	treatment	treatment	NOUN
dpc-5172	104	12	with	with	ADP
dpc-5172	104	13	tretinoin	tretinoin	NOUN
dpc-5172	104	14	compared	compare	VERB
dpc-5172	104	15	with	with	ADP
dpc-5172	104	16	a	a	DET
dpc-5172	104	17	vehicle	vehicle	NOUN
dpc-5172	104	18	all	all	PRON
dpc-5172	104	19	eight	eight	NUM
dpc-5172	104	20	trials	trial	NOUN
dpc-5172	104	21	assessed	assess	VERB
dpc-5172	104	22	clinical	clinical	ADJ
dpc-5172	104	23	improvement	improvement	NOUN
dpc-5172	104	24	in	in	ADP
dpc-5172	104	25	fine	fine	ADJ
dpc-5172	104	26	wrinkles	wrinkle	NOUN
dpc-5172	104	27	by	by	ADP
dpc-5172	104	28	comparing	compare	VERB
dpc-5172	104	29	tretinoin	tretinoin	NOUN
dpc-5172	104	30	treatment	treatment	NOUN
dpc-5172	104	31	with	with	ADP
dpc-5172	104	32	a	a	DET
dpc-5172	104	33	vehicle	vehicle	NOUN
dpc-5172	104	34	.	.	PUNCT
dpc-5172	105	1	a	a	DET
dpc-5172	105	2	significant	significant	ADJ
dpc-5172	105	3	improvement	improvement	NOUN
dpc-5172	105	4	in	in	ADP
dpc-5172	105	5	fine	fine	ADJ
dpc-5172	105	6	facial	facial	ADJ
dpc-5172	105	7	wrinkles	wrinkle	NOUN
dpc-5172	105	8	was	be	AUX
dpc-5172	105	9	observed	observe	VERB
dpc-5172	105	10	following	follow	VERB
dpc-5172	105	11	tretinoin	tretinoin	PROPN
dpc-5172	105	12	treatment	treatment	NOUN
dpc-5172	105	13	(	(	PUNCT
dpc-5172	105	14	md	md	PROPN
dpc-5172	105	15	:	:	PUNCT
dpc-5172	105	16	0.412	0.412	NUM
dpc-5172	105	17	;	;	PUNCT
dpc-5172	105	18	95	95	NUM
dpc-5172	105	19	%	%	NOUN
dpc-5172	105	20	ci	ci	NOUN
dpc-5172	105	21	:	:	PUNCT
dpc-5172	105	22	0.233–0.590	0.233–0.590	ADJ
dpc-5172	105	23	;	;	PUNCT
dpc-5172	105	24	p<0.001	p<0.001	X
dpc-5172	105	25	;	;	PUNCT
dpc-5172	105	26	i²=35.438	i²=35.438	PROPN
dpc-5172	105	27	%	%	NOUN
dpc-5172	105	28	;	;	PUNCT
dpc-5172	105	29	figure	figure	NOUN
dpc-5172	105	30	2	2	NUM
dpc-5172	105	31	)	)	PUNCT
dpc-5172	105	32	.	.	PUNCT
dpc-5172	106	1	moderate	moderate	ADJ
dpc-5172	106	2	heterogeneity	heterogeneity	PROPN
dpc-5172	106	3	was	be	AUX
dpc-5172	106	4	noted	note	VERB
dpc-5172	106	5	in	in	ADP
dpc-5172	106	6	the	the	DET
dpc-5172	106	7	included	include	VERB
dpc-5172	106	8	trials	trial	NOUN
dpc-5172	106	9	.	.	PUNCT
dpc-5172	107	1	to	to	PART
dpc-5172	107	2	examine	examine	VERB
dpc-5172	107	3	the	the	DET
dpc-5172	107	4	robustness	robustness	NOUN
dpc-5172	107	5	of	of	ADP
dpc-5172	107	6	the	the	DET
dpc-5172	107	7	findings	finding	NOUN
dpc-5172	107	8	,	,	PUNCT
dpc-5172	107	9	a	a	DET
dpc-5172	107	10	sensitivity	sensitivity	NOUN
dpc-5172	107	11	analysis	analysis	NOUN
dpc-5172	107	12	was	be	AUX
dpc-5172	107	13	performed	perform	VERB
dpc-5172	107	14	using	use	VERB
dpc-5172	107	15	the	the	DET
dpc-5172	107	16	one	one	NUM
dpc-5172	107	17	-	-	PUNCT
dpc-5172	107	18	study	study	NOUN
dpc-5172	107	19	-	-	PUNCT
dpc-5172	107	20	removal	removal	NOUN
dpc-5172	107	21	method	method	NOUN
dpc-5172	107	22	;	;	PUNCT
dpc-5172	107	23	the	the	DET
dpc-5172	107	24	significant	significant	ADJ
dpc-5172	107	25	effect	effect	NOUN
dpc-5172	107	26	of	of	ADP
dpc-5172	107	27	tretinoin	tretinoin	NOUN
dpc-5172	107	28	on	on	ADP
dpc-5172	107	29	fine	fine	ADJ
dpc-5172	107	30	wrinkle	wrinkle	NOUN
dpc-5172	107	31	improvement	improvement	NOUN
dpc-5172	107	32	remained	remain	VERB
dpc-5172	107	33	consistent	consistent	ADJ
dpc-5172	107	34	(	(	PUNCT
dpc-5172	107	35	p<0.001	p<0.001	ADJ
dpc-5172	107	36	;	;	PUNCT
dpc-5172	107	37	figure	figure	NOUN
dpc-5172	107	38	s1	s1	NOUN
dpc-5172	107	39	)	)	PUNCT
dpc-5172	107	40	.	.	PUNCT
dpc-5172	108	1	exclusion	exclusion	NOUN
dpc-5172	108	2	of	of	ADP
dpc-5172	108	3	any	any	DET
dpc-5172	108	4	individual	individual	ADJ
dpc-5172	108	5	trial	trial	NOUN
dpc-5172	108	6	did	do	AUX
dpc-5172	108	7	not	not	PART
dpc-5172	108	8	affect	affect	VERB
dpc-5172	108	9	the	the	DET
dpc-5172	108	10	overall	overall	ADJ
dpc-5172	108	11	significance	significance	NOUN
dpc-5172	108	12	of	of	ADP
dpc-5172	108	13	the	the	DET
dpc-5172	108	14	findings	finding	NOUN
dpc-5172	108	15	.	.	PUNCT
dpc-5172	109	1	however	however	ADV
dpc-5172	109	2	,	,	PUNCT
dpc-5172	109	3	egger	egger	NOUN
dpc-5172	109	4	’s	’s	PART
dpc-5172	109	5	test	test	NOUN
dpc-5172	109	6	indicated	indicate	VERB
dpc-5172	109	7	potential	potential	ADJ
dpc-5172	109	8	publication	publication	NOUN
dpc-5172	109	9	bias	bias	NOUN
dpc-5172	109	10	in	in	ADP
dpc-5172	109	11	the	the	DET
dpc-5172	109	12	studies	study	NOUN
dpc-5172	109	13	evaluating	evaluate	VERB
dpc-5172	109	14	improvements	improvement	NOUN
dpc-5172	109	15	in	in	ADP
dpc-5172	109	16	fine	fine	ADJ
dpc-5172	109	17	wrinkles	wrinkle	NOUN
dpc-5172	109	18	(	(	PUNCT
dpc-5172	109	19	p<0.001	p<0.001	ADJ
dpc-5172	109	20	;	;	PUNCT
dpc-5172	109	21	figure	figure	NOUN
dpc-5172	109	22	s2	s2	PROPN
dpc-5172	109	23	)	)	PUNCT
dpc-5172	109	24	.	.	PUNCT
dpc-5172	110	1	primary	primary	ADJ
dpc-5172	110	2	outcome	outcome	NOUN
dpc-5172	110	3	:	:	PUNCT
dpc-5172	110	4	improvement	improvement	NOUN
dpc-5172	110	5	in	in	ADP
dpc-5172	110	6	coarse	coarse	ADJ
dpc-5172	110	7	facial	facial	ADJ
dpc-5172	110	8	wrinkles	wrinkle	NOUN
dpc-5172	110	9	after	after	ADP
dpc-5172	110	10	treatment	treatment	NOUN
dpc-5172	110	11	with	with	ADP
dpc-5172	110	12	tretinoin	tretinoin	NOUN
dpc-5172	110	13	compared	compare	VERB
dpc-5172	110	14	with	with	ADP
dpc-5172	110	15	a	a	DET
dpc-5172	110	16	vehicle	vehicle	NOUN
dpc-5172	110	17	six	six	NUM
dpc-5172	110	18	trials	trial	NOUN
dpc-5172	110	19	,	,	PUNCT
dpc-5172	110	20	excluding	exclude	VERB
dpc-5172	110	21	those	those	PRON
dpc-5172	110	22	conducted	conduct	VERB
dpc-5172	110	23	by	by	ADP
dpc-5172	110	24	olsen	olsen	PROPN
dpc-5172	110	25	et	et	PROPN
dpc-5172	110	26	al	al	PROPN
dpc-5172	110	27	.	.	PUNCT
dpc-5172	111	1	[	[	X
dpc-5172	111	2	5	5	NUM
dpc-5172	111	3	]	]	PUNCT
dpc-5172	111	4	and	and	CCONJ
dpc-5172	111	5	weinstein	weinstein	PROPN
dpc-5172	111	6	et	et	PROPN
dpc-5172	111	7	al	al	PROPN
dpc-5172	111	8	.	.	PUNCT
dpc-5172	112	1	[	[	X
dpc-5172	112	2	19	19	NUM
dpc-5172	112	3	]	]	PUNCT
dpc-5172	112	4	,	,	PUNCT
dpc-5172	112	5	evaluated	evaluate	VERB
dpc-5172	112	6	the	the	DET
dpc-5172	112	7	efficacy	efficacy	NOUN
dpc-5172	112	8	of	of	ADP
dpc-5172	112	9	tretinoin	tretinoin	PROPN
dpc-5172	112	10	in	in	ADP
dpc-5172	112	11	improving	improve	VERB
dpc-5172	112	12	coarse	coarse	ADJ
dpc-5172	112	13	facial	facial	ADJ
dpc-5172	112	14	wrinkles	wrinkle	NOUN
dpc-5172	112	15	.	.	PUNCT
dpc-5172	113	1	consistent	consistent	ADJ
dpc-5172	113	2	with	with	ADP
dpc-5172	113	3	the	the	DET
dpc-5172	113	4	findings	finding	NOUN
dpc-5172	113	5	for	for	ADP
dpc-5172	113	6	fine	fine	ADJ
dpc-5172	113	7	wrinkles	wrinkle	NOUN
dpc-5172	113	8	,	,	PUNCT
dpc-5172	113	9	tretinoin	tretinoin	PROPN
dpc-5172	113	10	treatment	treatment	NOUN
dpc-5172	113	11	led	lead	VERB
dpc-5172	113	12	to	to	ADP
dpc-5172	113	13	a	a	DET
dpc-5172	113	14	significant	significant	ADJ
dpc-5172	113	15	improvement	improvement	NOUN
dpc-5172	113	16	in	in	ADP
dpc-5172	113	17	coarse	coarse	ADJ
dpc-5172	113	18	wrinkles	wrinkle	NOUN
dpc-5172	113	19	(	(	PUNCT
dpc-5172	113	20	md:0.245	md:0.245	NOUN
dpc-5172	113	21	;	;	PUNCT
dpc-5172	113	22	95	95	NUM
dpc-5172	113	23	%	%	NOUN
dpc-5172	113	24	ci	ci	NOUN
dpc-5172	113	25	:	:	PUNCT
dpc-5172	113	26	0.119–0.370	0.119–0.370	NUM
dpc-5172	113	27	;	;	PUNCT
dpc-5172	113	28	p<0.001	p<0.001	X
dpc-5172	113	29	;	;	PUNCT
dpc-5172	113	30	i²=0	i²=0	PROPN
dpc-5172	113	31	%	%	NOUN
dpc-5172	113	32	;	;	PUNCT
dpc-5172	113	33	figure	figure	NOUN
dpc-5172	113	34	3	3	NUM
dpc-5172	113	35	)	)	PUNCT
dpc-5172	113	36	.	.	PUNCT
dpc-5172	114	1	no	no	DET
dpc-5172	114	2	significant	significant	ADJ
dpc-5172	114	3	heterogeneity	heterogeneity	NOUN
dpc-5172	114	4	was	be	AUX
dpc-5172	114	5	detected	detect	VERB
dpc-5172	114	6	.	.	PUNCT
dpc-5172	115	1	in	in	ADP
dpc-5172	115	2	a	a	DET
dpc-5172	115	3	sensitivity	sensitivity	NOUN
dpc-5172	115	4	analysis	analysis	NOUN
dpc-5172	115	5	using	use	VERB
dpc-5172	115	6	the	the	DET
dpc-5172	115	7	one	one	NUM
dpc-5172	115	8	-	-	PUNCT
dpc-5172	115	9	study	study	NOUN
dpc-5172	115	10	-	-	PUNCT
dpc-5172	115	11	removal	removal	NOUN
dpc-5172	115	12	method	method	NOUN
dpc-5172	115	13	,	,	PUNCT
dpc-5172	115	14	the	the	DET
dpc-5172	115	15	significant	significant	ADJ
dpc-5172	115	16	effect	effect	NOUN
dpc-5172	115	17	of	of	ADP
dpc-5172	115	18	tretinoin	tretinoin	PROPN
dpc-5172	115	19	on	on	ADP
dpc-5172	115	20	coarse	coarse	ADJ
dpc-5172	115	21	wrinkle	wrinkle	NOUN
dpc-5172	115	22	improvement	improvement	NOUN
dpc-5172	115	23	remained	remain	VERB
dpc-5172	115	24	unchanged	unchanged	ADJ
dpc-5172	115	25	(	(	PUNCT
dpc-5172	115	26	p<0.001	p<0.001	ADJ
dpc-5172	115	27	;	;	PUNCT
dpc-5172	115	28	figure	figure	NOUN
dpc-5172	115	29	s3	s3	PROPN
dpc-5172	115	30	)	)	PUNCT
dpc-5172	115	31	.	.	PUNCT
dpc-5172	116	1	in	in	ADP
dpc-5172	116	2	addition	addition	NOUN
dpc-5172	116	3	,	,	PUNCT
dpc-5172	116	4	egger	egger	NOUN
dpc-5172	116	5	’s	’s	PART
dpc-5172	116	6	test	test	NOUN
dpc-5172	116	7	indicated	indicate	VERB
dpc-5172	116	8	no	no	DET
dpc-5172	116	9	significant	significant	ADJ
dpc-5172	116	10	publication	publication	NOUN
dpc-5172	116	11	bias	bias	NOUN
dpc-5172	116	12	in	in	ADP
dpc-5172	116	13	the	the	DET
dpc-5172	116	14	studies	study	NOUN
dpc-5172	116	15	assessing	assess	VERB
dpc-5172	116	16	improvements	improvement	NOUN
dpc-5172	116	17	in	in	ADP
dpc-5172	116	18	coarse	coarse	ADJ
dpc-5172	116	19	wrinkles	wrinkle	NOUN
dpc-5172	116	20	(	(	PUNCT
dpc-5172	116	21	p=0.457	p=0.457	NUM
dpc-5172	116	22	;	;	PUNCT
dpc-5172	116	23	figure	figure	NOUN
dpc-5172	116	24	s4	s4	PROPN
dpc-5172	116	25	)	)	PUNCT
dpc-5172	116	26	.	.	PUNCT
dpc-5172	117	1	the	the	DET
dpc-5172	117	2	primary	primary	ADJ
dpc-5172	117	3	and	and	CCONJ
dpc-5172	117	4	secondary	secondary	ADJ
dpc-5172	117	5	outcomes	outcome	NOUN
dpc-5172	117	6	were	be	AUX
dpc-5172	117	7	quantified	quantify	VERB
dpc-5172	117	8	using	use	VERB
dpc-5172	117	9	mean	mean	ADJ
dpc-5172	117	10	differences	difference	NOUN
dpc-5172	117	11	(	(	PUNCT
dpc-5172	117	12	md	md	PROPN
dpc-5172	117	13	)	)	PUNCT
dpc-5172	117	14	with	with	ADP
dpc-5172	117	15	corresponding	correspond	VERB
dpc-5172	117	16	95	95	NUM
dpc-5172	117	17	%	%	NOUN
dpc-5172	117	18	confidence	confidence	NOUN
dpc-5172	117	19	intervals	interval	NOUN
dpc-5172	117	20	(	(	PUNCT
dpc-5172	117	21	ci	ci	NOUN
dpc-5172	117	22	)	)	PUNCT
dpc-5172	117	23	.	.	PUNCT
dpc-5172	118	1	the	the	DET
dpc-5172	118	2	tertiary	tertiary	ADJ
dpc-5172	118	3	outcome	outcome	NOUN
dpc-5172	118	4	was	be	AUX
dpc-5172	118	5	quantified	quantify	VERB
dpc-5172	118	6	using	use	VERB
dpc-5172	118	7	or	or	CCONJ
dpc-5172	118	8	and	and	CCONJ
dpc-5172	118	9	their	their	PRON
dpc-5172	118	10	associated	associated	ADJ
dpc-5172	118	11	95	95	NUM
dpc-5172	118	12	%	%	NOUN
dpc-5172	118	13	ci	ci	NOUN
dpc-5172	118	14	.	.	PROPN
dpc-5172	118	15	heterogeneity	heterogeneity	PROPN
dpc-5172	118	16	among	among	ADP
dpc-5172	118	17	the	the	DET
dpc-5172	118	18	included	include	VERB
dpc-5172	118	19	trials	trial	NOUN
dpc-5172	118	20	was	be	AUX
dpc-5172	118	21	evaluated	evaluate	VERB
dpc-5172	118	22	using	use	VERB
dpc-5172	118	23	the	the	DET
dpc-5172	118	24	i²	i²	NOUN
dpc-5172	118	25	and	and	CCONJ
dpc-5172	118	26	cochran	cochran	NOUN
dpc-5172	118	27	’s	’s	PART
dpc-5172	118	28	q	q	PROPN
dpc-5172	118	29	statistics	statistic	NOUN
dpc-5172	118	30	,	,	PUNCT
dpc-5172	118	31	with	with	ADP
dpc-5172	118	32	i²	i²	NOUN
dpc-5172	118	33	values	value	NOUN
dpc-5172	118	34	of	of	ADP
dpc-5172	118	35	30	30	NUM
dpc-5172	118	36	%	%	NOUN
dpc-5172	118	37	,	,	PUNCT
dpc-5172	118	38	50	50	NUM
dpc-5172	118	39	%	%	NOUN
dpc-5172	118	40	,	,	PUNCT
dpc-5172	118	41	and	and	CCONJ
dpc-5172	118	42	75	75	NUM
dpc-5172	118	43	%	%	NOUN
dpc-5172	118	44	indicating	indicate	VERB
dpc-5172	118	45	moderate	moderate	ADJ
dpc-5172	118	46	,	,	PUNCT
dpc-5172	118	47	substantial	substantial	ADJ
dpc-5172	118	48	,	,	PUNCT
dpc-5172	118	49	and	and	CCONJ
dpc-5172	118	50	considerable	considerable	ADJ
dpc-5172	118	51	heterogeneity	heterogeneity	NOUN
dpc-5172	118	52	,	,	PUNCT
dpc-5172	118	53	respectively	respectively	ADV
dpc-5172	118	54	[	[	X
dpc-5172	118	55	18	18	NUM
dpc-5172	118	56	]	]	PUNCT
dpc-5172	118	57	.	.	PUNCT
dpc-5172	119	1	to	to	PART
dpc-5172	119	2	validate	validate	VERB
dpc-5172	119	3	the	the	DET
dpc-5172	119	4	robustness	robustness	NOUN
dpc-5172	119	5	of	of	ADP
dpc-5172	119	6	the	the	DET
dpc-5172	119	7	findings	finding	NOUN
dpc-5172	119	8	,	,	PUNCT
dpc-5172	119	9	sensitivity	sensitivity	NOUN
dpc-5172	119	10	analyses	analysis	NOUN
dpc-5172	119	11	were	be	AUX
dpc-5172	119	12	performed	perform	VERB
dpc-5172	119	13	using	use	VERB
dpc-5172	119	14	the	the	DET
dpc-5172	119	15	onestudy	onestudy	NOUN
dpc-5172	119	16	-	-	PUNCT
dpc-5172	119	17	removal	removal	NOUN
dpc-5172	119	18	method	method	NOUN
dpc-5172	119	19	.	.	PUNCT
dpc-5172	120	1	this	this	DET
dpc-5172	120	2	approach	approach	NOUN
dpc-5172	120	3	is	be	AUX
dpc-5172	120	4	used	use	VERB
dpc-5172	120	5	to	to	PART
dpc-5172	120	6	determine	determine	VERB
dpc-5172	120	7	whether	whether	SCONJ
dpc-5172	120	8	the	the	DET
dpc-5172	120	9	exclusion	exclusion	NOUN
dpc-5172	120	10	of	of	ADP
dpc-5172	120	11	any	any	DET
dpc-5172	120	12	single	single	ADJ
dpc-5172	120	13	trial	trial	NOUN
dpc-5172	120	14	results	result	NOUN
dpc-5172	120	15	in	in	ADP
dpc-5172	120	16	significant	significant	ADJ
dpc-5172	120	17	changes	change	NOUN
dpc-5172	120	18	in	in	ADP
dpc-5172	120	19	the	the	DET
dpc-5172	120	20	overall	overall	ADJ
dpc-5172	120	21	effect	effect	NOUN
dpc-5172	120	22	size	size	NOUN
dpc-5172	120	23	[	[	X
dpc-5172	120	24	18	18	NUM
dpc-5172	120	25	]	]	PUNCT
dpc-5172	120	26	.	.	PUNCT
dpc-5172	121	1	potential	potential	ADJ
dpc-5172	121	2	publication	publication	NOUN
dpc-5172	121	3	bias	bias	NOUN
dpc-5172	121	4	was	be	AUX
dpc-5172	121	5	evaluated	evaluate	VERB
dpc-5172	121	6	using	use	VERB
dpc-5172	121	7	funnel	funnel	NOUN
dpc-5172	121	8	plot	plot	NOUN
dpc-5172	121	9	analysis	analysis	NOUN
dpc-5172	121	10	and	and	CCONJ
dpc-5172	121	11	egger	egger	NOUN
dpc-5172	121	12	’s	’s	PART
dpc-5172	121	13	regression	regression	NOUN
dpc-5172	121	14	tests	test	NOUN
dpc-5172	121	15	.	.	PUNCT
dpc-5172	122	1	results	result	VERB
dpc-5172	122	2	a	a	DET
dpc-5172	122	3	total	total	NOUN
dpc-5172	122	4	of	of	ADP
dpc-5172	122	5	128	128	NUM
dpc-5172	122	6	relevant	relevant	ADJ
dpc-5172	122	7	randomized	randomize	VERB
dpc-5172	122	8	controlled	control	VERB
dpc-5172	122	9	trials	trial	NOUN
dpc-5172	122	10	were	be	AUX
dpc-5172	122	11	identified	identify	VERB
dpc-5172	122	12	through	through	ADP
dpc-5172	122	13	the	the	DET
dpc-5172	122	14	database	database	NOUN
dpc-5172	122	15	search	search	NOUN
dpc-5172	122	16	,	,	PUNCT
dpc-5172	122	17	of	of	ADP
dpc-5172	122	18	which	which	PRON
dpc-5172	122	19	eight	eight	NUM
dpc-5172	122	20	met	meet	VERB
dpc-5172	122	21	the	the	DET
dpc-5172	122	22	inclusion	inclusion	NOUN
dpc-5172	122	23	criteria	criterion	NOUN
dpc-5172	122	24	and	and	CCONJ
dpc-5172	122	25	were	be	AUX
dpc-5172	122	26	included	include	VERB
dpc-5172	122	27	in	in	ADP
dpc-5172	122	28	the	the	DET
dpc-5172	122	29	qualitative	qualitative	ADJ
dpc-5172	122	30	and	and	CCONJ
dpc-5172	122	31	quantitative	quantitative	ADJ
dpc-5172	122	32	syntheses	synthesis	NOUN
dpc-5172	122	33	(	(	PUNCT
dpc-5172	122	34	figure	figure	NOUN
dpc-5172	122	35	1	1	NUM
dpc-5172	122	36	)	)	PUNCT
dpc-5172	122	37	.	.	PUNCT
dpc-5172	123	1	these	these	DET
dpc-5172	123	2	eight	eight	NUM
dpc-5172	123	3	trials	trial	NOUN
dpc-5172	123	4	were	be	AUX
dpc-5172	123	5	published	publish	VERB
dpc-5172	123	6	between	between	ADP
dpc-5172	123	7	1988	1988	NUM
dpc-5172	123	8	and	and	CCONJ
dpc-5172	123	9	2006	2006	NUM
dpc-5172	123	10	.	.	PUNCT
dpc-5172	124	1	their	their	PRON
dpc-5172	124	2	characteristics	characteristic	NOUN
dpc-5172	124	3	are	be	AUX
dpc-5172	124	4	summarized	summarize	VERB
dpc-5172	124	5	in	in	ADP
dpc-5172	124	6	table	table	NOUN
dpc-5172	124	7	1	1	NUM
dpc-5172	124	8	and	and	CCONJ
dpc-5172	124	9	supplementary	supplementary	ADJ
dpc-5172	124	10	table	table	NOUN
dpc-5172	124	11	s4	s4	NOUN
dpc-5172	124	12	.	.	PUNCT
dpc-5172	125	1	collectively	collectively	ADV
dpc-5172	125	2	,	,	PUNCT
dpc-5172	125	3	the	the	DET
dpc-5172	125	4	trials	trial	NOUN
dpc-5172	125	5	enrolled	enrol	VERB
dpc-5172	125	6	1,361	1,361	NUM
dpc-5172	125	7	patients	patient	NOUN
dpc-5172	125	8	aged	age	VERB
dpc-5172	125	9	between	between	ADP
dpc-5172	125	10	29	29	NUM
dpc-5172	125	11	and	and	CCONJ
dpc-5172	125	12	76	76	NUM
dpc-5172	125	13	years	year	NOUN
dpc-5172	125	14	.	.	PUNCT
dpc-5172	126	1	all	all	DET
dpc-5172	126	2	trials	trial	NOUN
dpc-5172	126	3	were	be	AUX
dpc-5172	126	4	conducted	conduct	VERB
dpc-5172	126	5	in	in	ADP
dpc-5172	126	6	the	the	DET
dpc-5172	126	7	united	united	PROPN
dpc-5172	126	8	states	states	PROPN
dpc-5172	126	9	,	,	PUNCT
dpc-5172	126	10	with	with	ADP
dpc-5172	126	11	the	the	DET
dpc-5172	126	12	exception	exception	NOUN
dpc-5172	126	13	of	of	ADP
dpc-5172	126	14	one	one	NUM
dpc-5172	126	15	conducted	conduct	VERB
dpc-5172	126	16	in	in	ADP
dpc-5172	126	17	australia	australia	PROPN
dpc-5172	126	18	.	.	PUNCT
dpc-5172	127	1	the	the	DET
dpc-5172	127	2	baseline	baseline	ADJ
dpc-5172	127	3	severity	severity	NOUN
dpc-5172	127	4	of	of	ADP
dpc-5172	127	5	photoaging	photoage	VERB
dpc-5172	127	6	among	among	ADP
dpc-5172	127	7	the	the	DET
dpc-5172	127	8	participants	participant	NOUN
dpc-5172	127	9	ranged	range	VERB
dpc-5172	127	10	from	from	ADP
dpc-5172	127	11	mild	mild	ADJ
dpc-5172	127	12	to	to	ADP
dpc-5172	127	13	severe	severe	ADJ
dpc-5172	127	14	.	.	PUNCT
dpc-5172	128	1	the	the	DET
dpc-5172	128	2	average	average	ADJ
dpc-5172	128	3	follow	follow	VERB
dpc-5172	128	4	-	-	PUNCT
dpc-5172	128	5	up	up	ADP
dpc-5172	128	6	duration	duration	NOUN
dpc-5172	128	7	varied	varied	ADJ
dpc-5172	128	8	from	from	ADP
dpc-5172	128	9	16	16	NUM
dpc-5172	128	10	weeks	week	NOUN
dpc-5172	128	11	to	to	ADP
dpc-5172	128	12	two	two	NUM
dpc-5172	128	13	years	year	NOUN
dpc-5172	128	14	.	.	PUNCT
dpc-5172	129	1	study	study	NOUN
dpc-5172	129	2	quality	quality	NOUN
dpc-5172	129	3	assessments	assessment	NOUN
dpc-5172	129	4	are	be	AUX
dpc-5172	129	5	presented	present	VERB
dpc-5172	129	6	in	in	ADP
dpc-5172	129	7	table	table	NOUN
dpc-5172	129	8	s5	s5	PROPN
dpc-5172	129	9	,	,	PUNCT
dpc-5172	129	10	and	and	CCONJ
dpc-5172	129	11	detailed	detailed	ADJ
dpc-5172	129	12	data	datum	NOUN
dpc-5172	129	13	on	on	ADP
dpc-5172	129	14	clinical	clinical	ADJ
dpc-5172	129	15	improvements	improvement	NOUN
dpc-5172	129	16	and	and	CCONJ
dpc-5172	129	17	patient	patient	NOUN
dpc-5172	129	18	-	-	PUNCT
dpc-5172	129	19	reported	report	VERB
dpc-5172	129	20	outcomes	outcome	NOUN
dpc-5172	129	21	from	from	ADP
dpc-5172	129	22	all	all	DET
dpc-5172	129	23	trials	trial	NOUN
dpc-5172	129	24	are	be	AUX
dpc-5172	129	25	provided	provide	VERB
dpc-5172	129	26	in	in	ADP
dpc-5172	129	27	table	table	NOUN
dpc-5172	129	28	s3	s3	PROPN
dpc-5172	129	29	.	.	PUNCT
dpc-5172	129	30	figure	figure	NOUN
dpc-5172	129	31	1	1	NUM
dpc-5172	129	32	.	.	PUNCT
dpc-5172	129	33	prisma	prisma	PROPN
dpc-5172	129	34	flow	flow	PROPN
dpc-5172	129	35	diagram	diagram	NOUN
dpc-5172	129	36	.	.	PUNCT
dpc-5172	130	1	review	review	VERB
dpc-5172	130	2	|	|	ADV
dpc-5172	130	3	dermatol	dermatol	ADJ
dpc-5172	130	4	pract	pract	NOUN
dpc-5172	130	5	concept	concept	NOUN
dpc-5172	130	6	.	.	PUNCT
dpc-5172	131	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	131	2	5	5	NUM
dpc-5172	131	3	t	t	PROPN
dpc-5172	131	4	ab	ab	PROPN
dpc-5172	131	5	le	le	PROPN
dpc-5172	131	6	1	1	NUM
dpc-5172	131	7	.	.	PUNCT
dpc-5172	132	1	r	r	NOUN
dpc-5172	132	2	et	et	NOUN
dpc-5172	132	3	ri	ri	PROPN
dpc-5172	132	4	ev	ev	INTJ
dpc-5172	132	5	ed	ed	PROPN
dpc-5172	132	6	t	t	PROPN
dpc-5172	132	7	ri	ri	PROPN
dpc-5172	133	1	al	al	PROPN
dpc-5172	133	2	s	s	PROPN
dpc-5172	133	3	in	in	ADP
dpc-5172	133	4	ve	ve	PROPN
dpc-5172	133	5	st	st	PROPN
dpc-5172	133	6	ig	ig	PROPN
dpc-5172	133	7	at	at	ADP
dpc-5172	133	8	in	in	ADP
dpc-5172	133	9	g	g	PROPN
dpc-5172	133	10	th	th	X
dpc-5172	133	11	e	e	X
dpc-5172	133	12	e	e	X
dpc-5172	133	13	ff	ff	X
dpc-5172	133	14	ec	ec	PROPN
dpc-5172	133	15	tiv	tiv	PROPN
dpc-5172	133	16	en	en	PROPN
dpc-5172	133	17	es	es	X
dpc-5172	133	18	s	s	PROPN
dpc-5172	133	19	of	of	ADP
dpc-5172	133	20	t	t	NOUN
dpc-5172	133	21	op	op	NOUN
dpc-5172	133	22	ic	ic	PROPN
dpc-5172	133	23	al	al	PROPN
dpc-5172	133	24	r	r	PROPN
dpc-5172	133	25	et	et	NOUN
dpc-5172	133	26	in	in	ADP
dpc-5172	133	27	oi	oi	PROPN
dpc-5172	133	28	d	d	PROPN
dpc-5172	133	29	t	t	PROPN
dpc-5172	133	30	re	re	NOUN
dpc-5172	133	31	at	at	ADP
dpc-5172	133	32	m	m	PROPN
dpc-5172	133	33	en	en	ADP
dpc-5172	133	34	t	t	PROPN
dpc-5172	133	35	in	in	ADP
dpc-5172	133	36	i	i	PRON
dpc-5172	133	37	m	m	VERB
dpc-5172	133	38	pr	pr	INTJ
dpc-5172	133	39	ov	ov	INTJ
dpc-5172	133	40	in	in	ADP
dpc-5172	133	41	g	g	PROPN
dpc-5172	133	42	ph	ph	PROPN
dpc-5172	133	43	ot	ot	INTJ
dpc-5172	133	44	od	od	X
dpc-5172	133	45	am	am	PROPN
dpc-5172	133	46	ag	ag	PROPN
dpc-5172	133	47	ein	ein	PROPN
dpc-5172	133	48	du	du	PROPN
dpc-5172	133	49	ce	ce	PROPN
dpc-5172	133	50	d	d	PROPN
dpc-5172	133	51	w	w	PROPN
dpc-5172	133	52	ri	ri	PROPN
dpc-5172	133	53	nk	nk	PROPN
dpc-5172	133	54	le	le	PROPN
dpc-5172	133	55	s.	s.	PROPN
dpc-5172	133	56	fi	fi	PROPN
dpc-5172	133	57	rs	rs	PROPN
dpc-5172	133	58	t	t	X
dpc-5172	133	59	au	au	X
dpc-5172	133	60	th	th	X
dpc-5172	133	61	or	or	CCONJ
dpc-5172	133	62	an	an	DET
dpc-5172	133	63	d	d	PROPN
dpc-5172	133	64	ye	ye	PROPN
dpc-5172	133	65	ar	ar	PROPN
dpc-5172	133	66	c	c	PROPN
dpc-5172	133	67	ou	ou	PROPN
dpc-5172	133	68	nt	not	PART
dpc-5172	133	69	ry	ry	PROPN
dpc-5172	133	70	po	po	PROPN
dpc-5172	133	71	pu	pu	PROPN
dpc-5172	133	72	la	la	PROPN
dpc-5172	133	73	ti	ti	PROPN
dpc-5172	133	74	on	on	ADP
dpc-5172	133	75	pa	pa	PROPN
dpc-5172	133	76	ti	ti	PROPN
dpc-5172	133	77	en	en	PROPN
dpc-5172	133	78	t	t	PROPN
dpc-5172	133	79	nu	nu	PROPN
dpc-5172	133	80	m	m	VERB
dpc-5172	133	81	be	be	VERB
dpc-5172	133	82	r	r	NOUN
dpc-5172	133	83	(	(	PUNCT
dpc-5172	133	84	t	t	X
dpc-5172	133	85	re	re	ADJ
dpc-5172	133	86	ti	ti	PROPN
dpc-5172	134	1	no	no	INTJ
dpc-5172	134	2	in	in	ADV
dpc-5172	134	3	/	/	PUNCT
dpc-5172	134	4	ve	ve	VERB
dpc-5172	134	5	hi	hi	INTJ
dpc-5172	134	6	cl	cl	NOUN
dpc-5172	134	7	e	e	NOUN
dpc-5172	134	8	)	)	PUNCT
dpc-5172	134	9	,	,	PUNCT
dpc-5172	134	10	 	 	SPACE
dpc-5172	134	11	n	n	X
dpc-5172	134	12	se	se	X
dpc-5172	134	13	x	x	X
dpc-5172	134	14	(	(	PUNCT
dpc-5172	134	15	m	m	VERB
dpc-5172	134	16	al	al	PROPN
dpc-5172	134	17	e/	e/	PROPN
dpc-5172	134	18	fe	fe	X
dpc-5172	134	19	m	m	PROPN
dpc-5172	134	20	al	al	PROPN
dpc-5172	134	21	e	e	PROPN
dpc-5172	134	22	)	)	PUNCT
dpc-5172	134	23	,	,	PUNCT
dpc-5172	134	24	 	 	SPACE
dpc-5172	134	25	n	n	CCONJ
dpc-5172	134	26	a	a	DET
dpc-5172	134	27	ge	ge	PROPN
dpc-5172	134	28	1	1	NUM
dpc-5172	134	29	st	st	PROPN
dpc-5172	134	30	ud	ud	INTJ
dpc-5172	134	31	y	y	PROPN
dpc-5172	134	32	de	de	PROPN
dpc-5172	134	33	si	si	PROPN
dpc-5172	134	34	gn	gn	PROPN
dpc-5172	134	35	a	a	DET
dpc-5172	134	36	llo	llo	INTJ
dpc-5172	134	37	ca	ca	NOUN
dpc-5172	134	38	ti	ti	PROPN
dpc-5172	134	39	on	on	ADP
dpc-5172	134	40	co	co	X
dpc-5172	134	41	nc	nc	PROPN
dpc-5172	134	42	ea	ea	PROPN
dpc-5172	134	43	lm	lm	INTJ
dpc-5172	134	44	en	en	PROPN
dpc-5172	134	45	t	t	PROPN
dpc-5172	134	46	r	r	NOUN
dpc-5172	134	47	an	an	DET
dpc-5172	134	48	do	do	NOUN
dpc-5172	134	49	m	m	NOUN
dpc-5172	134	50	iz	iz	INTJ
dpc-5172	134	51	at	at	ADP
dpc-5172	134	52	io	io	PROPN
dpc-5172	134	53	n	n	PRON
dpc-5172	134	54	fu	fu	PROPN
dpc-5172	134	55	nd	nd	ADV
dpc-5172	134	56	in	in	ADP
dpc-5172	134	57	g/	g/	NOUN
dpc-5172	134	58	gr	gr	ADP
dpc-5172	134	59	an	an	DET
dpc-5172	134	60	ts	ts	NOUN
dpc-5172	134	61	/s	/s	NOUN
dpc-5172	134	62	up	up	ADP
dpc-5172	134	63	po	po	X
dpc-5172	134	64	rt	rt	PROPN
dpc-5172	134	65	w	w	PROPN
dpc-5172	134	66	ei	ei	PROPN
dpc-5172	134	67	ss	ss	NOUN
dpc-5172	134	68	1	1	NUM
dpc-5172	134	69	98	98	NUM
dpc-5172	134	70	8	8	NUM
dpc-5172	134	71	u	u	PROPN
dpc-5172	134	72	sa	sa	PROPN
dpc-5172	134	73	h	h	PROPN
dpc-5172	134	74	ea	ea	PROPN
dpc-5172	135	1	lt	lt	PRON
dpc-5172	135	2	hy	hy	PROPN
dpc-5172	136	1	w	w	PROPN
dpc-5172	136	2	hi	hi	INTJ
dpc-5172	136	3	te	te	INTJ
dpc-5172	136	4	pa	pa	PROPN
dpc-5172	136	5	ti	ti	PROPN
dpc-5172	136	6	en	en	X
dpc-5172	136	7	ts	ts	ADP
dpc-5172	136	8	15	15	NUM
dpc-5172	136	9	/1	/1	NOUN
dpc-5172	136	10	5	5	NUM
dpc-5172	136	11	se	se	ADV
dpc-5172	136	12	x	x	PUNCT
dpc-5172	137	1	no	no	INTJ
dpc-5172	137	2	t	t	NOUN
dpc-5172	137	3	m	m	VERB
dpc-5172	137	4	en	en	ADP
dpc-5172	137	5	ti	ti	NOUN
dpc-5172	137	6	on	on	ADP
dpc-5172	137	7	ed	ed	PROPN
dpc-5172	137	8	50	50	NUM
dpc-5172	137	9	(	(	PUNCT
dpc-5172	137	10	35	35	NUM
dpc-5172	137	11	–	–	SYM
dpc-5172	137	12	7	7	NUM
dpc-5172	137	13	0	0	NUM
dpc-5172	137	14	)	)	PUNCT
dpc-5172	137	15	r	r	NOUN
dpc-5172	137	16	c	c	PROPN
dpc-5172	137	17	t	t	PROPN
dpc-5172	137	18	,	,	PUNCT
dpc-5172	137	19	do	do	VERB
dpc-5172	137	20	ub	ub	X
dpc-5172	137	21	le	le	PROPN
dpc-5172	138	1	-b	-b	PUNCT
dpc-5172	138	2	lin	lin	PROPN
dpc-5172	138	3	d	d	PROPN
dpc-5172	138	4	n	n	PROPN
dpc-5172	138	5	ot	ot	INTJ
dpc-5172	138	6	m	m	VERB
dpc-5172	138	7	en	en	ADP
dpc-5172	138	8	ti	ti	NOUN
dpc-5172	138	9	on	on	ADP
dpc-5172	138	10	ed	ed	NOUN
dpc-5172	138	11	ta	ta	PROPN
dpc-5172	138	12	bl	bl	PROPN
dpc-5172	138	13	e	e	PROPN
dpc-5172	138	14	of	of	ADP
dpc-5172	138	15	r	r	NOUN
dpc-5172	138	16	an	an	DET
dpc-5172	138	17	do	do	NOUN
dpc-5172	138	18	m	m	PROPN
dpc-5172	138	19	nu	nu	INTJ
dpc-5172	138	20	m	m	VERB
dpc-5172	138	21	be	be	VERB
dpc-5172	138	22	rs	rs	ADJ
dpc-5172	138	23	o	o	PROPN
dpc-5172	138	24	rt	rt	PROPN
dpc-5172	138	25	ho	ho	PROPN
dpc-5172	138	26	ph	ph	PROPN
dpc-5172	138	27	ar	ar	PROPN
dpc-5172	138	28	m	m	PROPN
dpc-5172	138	29	ac	ac	PROPN
dpc-5172	138	30	eu	eu	PROPN
dpc-5172	138	31	ti	ti	PROPN
dpc-5172	138	32	ca	can	AUX
dpc-5172	138	33	l	l	NOUN
dpc-5172	138	34	c	c	NOUN
dpc-5172	138	35	or	or	CCONJ
dpc-5172	138	36	p.	p.	PROPN
dpc-5172	138	37	b	b	PROPN
dpc-5172	139	1	ab	ab	PROPN
dpc-5172	139	2	co	co	NOUN
dpc-5172	139	3	ck	ck	PROPN
dpc-5172	139	4	d	d	X
dpc-5172	139	5	er	er	INTJ
dpc-5172	139	6	m	m	VERB
dpc-5172	139	7	at	at	ADP
dpc-5172	139	8	ol	ol	PROPN
dpc-5172	139	9	og	og	PROPN
dpc-5172	139	10	ic	ic	PROPN
dpc-5172	139	11	e	e	PROPN
dpc-5172	139	12	nd	nd	INTJ
dpc-5172	139	13	ow	ow	INTJ
dpc-5172	139	14	m	m	PROPN
dpc-5172	139	15	en	en	ADP
dpc-5172	139	16	t	t	PROPN
dpc-5172	139	17	w	w	PROPN
dpc-5172	139	18	ei	ei	PROPN
dpc-5172	139	19	ns	ns	INTJ
dpc-5172	139	20	te	te	PROPN
dpc-5172	139	21	in	in	ADP
dpc-5172	139	22	19	19	NUM
dpc-5172	139	23	91	91	NUM
dpc-5172	139	24	u	u	NOUN
dpc-5172	139	25	sa	sa	PROPN
dpc-5172	139	26	h	h	PROPN
dpc-5172	140	1	ea	ea	PROPN
dpc-5172	141	1	lt	lt	PRON
dpc-5172	142	1	hy	hy	PROPN
dpc-5172	143	1	w	w	PROPN
dpc-5172	143	2	hi	hi	INTJ
dpc-5172	143	3	te	te	INTJ
dpc-5172	143	4	pa	pa	PROPN
dpc-5172	143	5	ti	ti	PROPN
dpc-5172	143	6	en	en	X
dpc-5172	143	7	ts	ts	ADP
dpc-5172	143	8	20	20	NUM
dpc-5172	143	9	0/	0/	NUM
dpc-5172	143	10	99	99	NUM
dpc-5172	144	1	34	34	NUM
dpc-5172	144	2	/2	/2	NUM
dpc-5172	145	1	65	65	NUM
dpc-5172	145	2	41	41	NUM
dpc-5172	145	3	(	(	PUNCT
dpc-5172	145	4	29	29	NUM
dpc-5172	145	5	–	–	SYM
dpc-5172	145	6	5	5	NUM
dpc-5172	145	7	0	0	NUM
dpc-5172	145	8	)	)	PUNCT
dpc-5172	145	9	r	r	NOUN
dpc-5172	145	10	c	c	PROPN
dpc-5172	145	11	t	t	PROPN
dpc-5172	145	12	,	,	PUNCT
dpc-5172	145	13	do	do	VERB
dpc-5172	145	14	ub	ub	X
dpc-5172	145	15	le	le	PROPN
dpc-5172	146	1	-b	-b	PUNCT
dpc-5172	146	2	lin	lin	PROPN
dpc-5172	146	3	d	d	PROPN
dpc-5172	146	4	n	n	PROPN
dpc-5172	146	5	ot	ot	INTJ
dpc-5172	146	6	m	m	VERB
dpc-5172	146	7	en	en	ADP
dpc-5172	146	8	ti	ti	NOUN
dpc-5172	146	9	on	on	ADP
dpc-5172	146	10	ed	ed	NOUN
dpc-5172	146	11	r	r	NOUN
dpc-5172	146	12	an	an	DET
dpc-5172	146	13	do	do	NOUN
dpc-5172	146	14	m	m	NOUN
dpc-5172	146	15	iz	iz	INTJ
dpc-5172	146	16	at	at	ADP
dpc-5172	146	17	io	io	X
dpc-5172	146	18	n	n	X
dpc-5172	146	19	co	co	X
dpc-5172	146	20	de	de	X
dpc-5172	146	21	r	r	NOUN
dpc-5172	146	22	.	.	PUNCT
dpc-5172	147	1	w	w	X
dpc-5172	147	2	.	.	PUNCT
dpc-5172	148	1	j	j	PROPN
dpc-5172	149	1	oh	oh	INTJ
dpc-5172	149	2	ns	ns	NOUN
dpc-5172	149	3	on	on	ADP
dpc-5172	149	4	ph	ph	PROPN
dpc-5172	149	5	ar	ar	PROPN
dpc-5172	149	6	m	m	PROPN
dpc-5172	149	7	ac	ac	PROPN
dpc-5172	149	8	eu	eu	PROPN
dpc-5172	149	9	ti	ti	PROPN
dpc-5172	149	10	ca	ca	NOUN
dpc-5172	149	11	l	l	NOUN
dpc-5172	149	12	r	r	NOUN
dpc-5172	149	13	es	es	X
dpc-5172	149	14	ea	ea	PROPN
dpc-5172	150	1	rc	rc	PROPN
dpc-5172	150	2	h	h	PROPN
dpc-5172	150	3	in	in	ADP
dpc-5172	150	4	st	st	PROPN
dpc-5172	150	5	it	it	PRON
dpc-5172	150	6	ut	ut	PROPN
dpc-5172	150	7	e	e	X
dpc-5172	150	8	o	o	X
dpc-5172	150	9	ls	ls	X
dpc-5172	150	10	en	en	ADP
dpc-5172	150	11	1	1	NUM
dpc-5172	150	12	99	99	NUM
dpc-5172	150	13	2	2	NUM
dpc-5172	150	14	u	u	NOUN
dpc-5172	150	15	sa	sa	PROPN
dpc-5172	150	16	h	h	PROPN
dpc-5172	150	17	ea	ea	PROPN
dpc-5172	151	1	lt	lt	PRON
dpc-5172	151	2	hy	hy	PROPN
dpc-5172	152	1	w	w	PROPN
dpc-5172	152	2	hi	hi	INTJ
dpc-5172	152	3	te	te	INTJ
dpc-5172	152	4	pa	pa	PROPN
dpc-5172	152	5	ti	ti	PROPN
dpc-5172	152	6	en	en	X
dpc-5172	152	7	ts	ts	ADP
dpc-5172	152	8	22	22	NUM
dpc-5172	152	9	4/	4/	NUM
dpc-5172	152	10	72	72	NUM
dpc-5172	152	11	t	t	NOUN
dpc-5172	152	12	re	re	VERB
dpc-5172	152	13	ti	ti	PROPN
dpc-5172	152	14	no	no	INTJ
dpc-5172	152	15	in	in	ADP
dpc-5172	152	16	0	0	NUM
dpc-5172	152	17	.	.	PUNCT
dpc-5172	153	1	05	05	NUM
dpc-5172	153	2	%	%	NOUN
dpc-5172	153	3	:	:	PUNCT
dpc-5172	153	4	5	5	NUM
dpc-5172	153	5	5/	5/	NUM
dpc-5172	153	6	21	21	NUM
dpc-5172	153	7	v	v	NUM
dpc-5172	153	8	eh	eh	INTJ
dpc-5172	153	9	ic	ic	PROPN
dpc-5172	153	10	le	le	X
dpc-5172	153	11	:	:	PUNCT
dpc-5172	153	12	5	5	NUM
dpc-5172	153	13	0/	0/	NUM
dpc-5172	153	14	22	22	NUM
dpc-5172	153	15	42	42	NUM
dpc-5172	153	16	.5	.5	NUM
dpc-5172	153	17	(	(	PUNCT
dpc-5172	153	18	3	3	NUM
dpc-5172	153	19	0	0	NUM
dpc-5172	153	20	–	–	PUNCT
dpc-5172	153	21	58	58	NUM
dpc-5172	153	22	)	)	PUNCT
dpc-5172	153	23	r	r	NOUN
dpc-5172	153	24	c	c	PROPN
dpc-5172	153	25	t	t	PROPN
dpc-5172	153	26	,	,	PUNCT
dpc-5172	153	27	do	do	VERB
dpc-5172	153	28	ub	ub	X
dpc-5172	153	29	le	le	PROPN
dpc-5172	154	1	-b	-b	PUNCT
dpc-5172	154	2	lin	lin	PROPN
dpc-5172	154	3	d	d	PROPN
dpc-5172	154	4	d	d	PROPN
dpc-5172	154	5	ou	ou	PROPN
dpc-5172	154	6	bl	bl	PROPN
dpc-5172	154	7	ebl	ebl	PROPN
dpc-5172	154	8	in	in	ADP
dpc-5172	154	9	d	d	PROPN
dpc-5172	154	10	tu	tu	PROPN
dpc-5172	154	11	be	be	AUX
dpc-5172	154	12	s	s	X
dpc-5172	154	13	n	n	PRON
dpc-5172	154	14	ot	ot	NOUN
dpc-5172	154	15	m	m	VERB
dpc-5172	154	16	en	en	ADP
dpc-5172	154	17	ti	ti	NOUN
dpc-5172	154	18	on	on	ADP
dpc-5172	154	19	ed	ed	NOUN
dpc-5172	154	20	r	r	NOUN
dpc-5172	154	21	.	.	PUNCT
dpc-5172	155	1	w	w	X
dpc-5172	155	2	.	.	PUNCT
dpc-5172	156	1	j	j	PROPN
dpc-5172	157	1	oh	oh	INTJ
dpc-5172	157	2	ns	ns	NOUN
dpc-5172	157	3	on	on	ADP
dpc-5172	157	4	ph	ph	PROPN
dpc-5172	157	5	ar	ar	PROPN
dpc-5172	157	6	m	m	PROPN
dpc-5172	157	7	ac	ac	PROPN
dpc-5172	157	8	eu	eu	PROPN
dpc-5172	157	9	ti	ti	PROPN
dpc-5172	157	10	ca	ca	NOUN
dpc-5172	157	11	l	l	NOUN
dpc-5172	157	12	r	r	NOUN
dpc-5172	157	13	es	es	X
dpc-5172	157	14	ea	ea	PROPN
dpc-5172	158	1	rc	rc	PROPN
dpc-5172	158	2	h	h	PROPN
dpc-5172	158	3	in	in	ADP
dpc-5172	158	4	st	st	PROPN
dpc-5172	159	1	it	it	PRON
dpc-5172	159	2	ut	ut	PROPN
dpc-5172	159	3	e	e	PROPN
dpc-5172	159	4	a	a	PRON
dpc-5172	159	5	nd	nd	INTJ
dpc-5172	159	6	re	re	NOUN
dpc-5172	159	7	an	an	DET
dpc-5172	159	8	o	o	NOUN
dpc-5172	159	9	19	19	NUM
dpc-5172	159	10	93	93	NUM
dpc-5172	159	11	u	u	NOUN
dpc-5172	159	12	sa	sa	PROPN
dpc-5172	159	13	w	w	PROPN
dpc-5172	159	14	hi	hi	INTJ
dpc-5172	159	15	te	te	INTJ
dpc-5172	159	16	pa	pa	PROPN
dpc-5172	159	17	ti	ti	PROPN
dpc-5172	159	18	en	en	X
dpc-5172	159	19	ts	ts	ADP
dpc-5172	159	20	17	17	NUM
dpc-5172	159	21	/1	/1	NOUN
dpc-5172	159	22	7	7	NUM
dpc-5172	159	23	to	to	ADP
dpc-5172	159	24	ta	ta	PROPN
dpc-5172	159	25	l	l	NOUN
dpc-5172	159	26	:	:	PUNCT
dpc-5172	159	27	28	28	NUM
dpc-5172	159	28	/6	/6	NUM
dpc-5172	159	29	41	41	NUM
dpc-5172	159	30	(	(	PUNCT
dpc-5172	159	31	31	31	NUM
dpc-5172	159	32	–	–	SYM
dpc-5172	159	33	5	5	NUM
dpc-5172	159	34	0	0	NUM
dpc-5172	159	35	)	)	PUNCT
dpc-5172	159	36	r	r	NOUN
dpc-5172	159	37	c	c	PROPN
dpc-5172	159	38	t	t	PROPN
dpc-5172	159	39	,	,	PUNCT
dpc-5172	159	40	do	do	VERB
dpc-5172	159	41	ub	ub	X
dpc-5172	159	42	le	le	PROPN
dpc-5172	160	1	-b	-b	PUNCT
dpc-5172	160	2	lin	lin	PROPN
dpc-5172	160	3	d	d	PROPN
dpc-5172	160	4	n	n	PROPN
dpc-5172	160	5	ot	ot	INTJ
dpc-5172	160	6	m	m	VERB
dpc-5172	160	7	en	en	ADP
dpc-5172	160	8	ti	ti	NOUN
dpc-5172	160	9	on	on	ADP
dpc-5172	160	10	ed	ed	PROPN
dpc-5172	160	11	n	n	PROPN
dpc-5172	160	12	ot	ot	VERB
dpc-5172	160	13	m	m	VERB
dpc-5172	160	14	en	en	ADP
dpc-5172	160	15	ti	ti	NOUN
dpc-5172	160	16	on	on	ADP
dpc-5172	160	17	ed	ed	NOUN
dpc-5172	160	18	o	o	PROPN
dpc-5172	160	19	rt	rt	PROPN
dpc-5172	160	20	ho	ho	PROPN
dpc-5172	161	1	p	p	PROPN
dpc-5172	161	2	ha	ha	INTJ
dpc-5172	161	3	rm	rm	PROPN
dpc-5172	161	4	ac	ac	PROPN
dpc-5172	161	5	eu	eu	PROPN
dpc-5172	161	6	ti	ti	PROPN
dpc-5172	161	7	ca	can	AUX
dpc-5172	161	8	l	l	NOUN
dpc-5172	161	9	c	c	NOUN
dpc-5172	161	10	or	or	CCONJ
dpc-5172	161	11	po	po	INTJ
dpc-5172	161	12	ra	ra	NOUN
dpc-5172	161	13	ti	ti	PROPN
dpc-5172	161	14	on	on	ADP
dpc-5172	161	15	l	l	PROPN
dpc-5172	161	16	ow	ow	PROPN
dpc-5172	161	17	e	e	PROPN
dpc-5172	161	18	19	19	NUM
dpc-5172	161	19	94	94	NUM
dpc-5172	161	20	a	a	DET
dpc-5172	161	21	us	we	PRON
dpc-5172	161	22	tr	tr	PROPN
dpc-5172	161	23	al	al	PROPN
dpc-5172	161	24	ia	ia	PROPN
dpc-5172	161	25	h	h	PROPN
dpc-5172	161	26	ea	ea	PROPN
dpc-5172	162	1	lt	lt	PRON
dpc-5172	162	2	hy	hy	PROPN
dpc-5172	163	1	w	w	PROPN
dpc-5172	163	2	hi	hi	INTJ
dpc-5172	163	3	te	te	INTJ
dpc-5172	163	4	pa	pa	PROPN
dpc-5172	163	5	ti	ti	PROPN
dpc-5172	163	6	en	en	ADP
dpc-5172	163	7	ts	ts	ADP
dpc-5172	163	8	62	62	NUM
dpc-5172	163	9	/6	/6	NOUN
dpc-5172	163	10	3	3	NUM
dpc-5172	163	11	to	to	ADP
dpc-5172	163	12	ta	ta	ADP
dpc-5172	163	13	l	l	NOUN
dpc-5172	163	14	:	:	PUNCT
dpc-5172	163	15	11	11	NUM
dpc-5172	163	16	5/	5/	NUM
dpc-5172	163	17	10	10	NUM
dpc-5172	163	18	46	46	NUM
dpc-5172	163	19	(	(	PUNCT
dpc-5172	163	20	30	30	NUM
dpc-5172	163	21	–	–	SYM
dpc-5172	163	22	6	6	NUM
dpc-5172	163	23	5	5	NUM
dpc-5172	163	24	)	)	PUNCT
dpc-5172	163	25	r	r	NOUN
dpc-5172	163	26	c	c	PROPN
dpc-5172	163	27	t	t	PROPN
dpc-5172	163	28	,	,	PUNCT
dpc-5172	163	29	do	do	VERB
dpc-5172	163	30	ub	ub	X
dpc-5172	163	31	le	le	PROPN
dpc-5172	164	1	-b	-b	PUNCT
dpc-5172	164	2	lin	lin	PROPN
dpc-5172	164	3	d	d	PROPN
dpc-5172	164	4	n	n	PROPN
dpc-5172	164	5	ot	ot	INTJ
dpc-5172	164	6	m	m	VERB
dpc-5172	164	7	en	en	ADP
dpc-5172	164	8	ti	ti	NOUN
dpc-5172	164	9	on	on	ADP
dpc-5172	164	10	ed	ed	PROPN
dpc-5172	164	11	c	c	PROPN
dpc-5172	164	12	om	om	PROPN
dpc-5172	164	13	pu	pu	PROPN
dpc-5172	164	14	te	te	PROPN
dpc-5172	164	15	rge	rge	PROPN
dpc-5172	164	16	ne	ne	X
dpc-5172	164	17	ra	ra	PROPN
dpc-5172	165	1	te	te	PROPN
dpc-5172	165	2	d	d	X
dpc-5172	165	3	ra	ra	PROPN
dpc-5172	165	4	nd	nd	INTJ
dpc-5172	165	5	om	om	PROPN
dpc-5172	165	6	iz	iz	INTJ
dpc-5172	165	7	at	at	ADP
dpc-5172	165	8	io	io	PROPN
dpc-5172	165	9	n	n	X
dpc-5172	165	10	co	co	PROPN
dpc-5172	165	11	de	de	PROPN
dpc-5172	165	12	ja	ja	PROPN
dpc-5172	165	13	ns	ns	PROPN
dpc-5172	165	14	se	se	PROPN
dpc-5172	165	15	nc	nc	PROPN
dpc-5172	165	16	ila	ila	PROPN
dpc-5172	165	17	g	g	PROPN
dpc-5172	165	18	pt	pt	PROPN
dpc-5172	165	19	y	y	PROPN
dpc-5172	165	20	l	l	NOUN
dpc-5172	165	21	td	td	NOUN
dpc-5172	165	22	.	.	PUNCT
dpc-5172	166	1	n	n	CCONJ
dpc-5172	166	2	yi	yi	NOUN
dpc-5172	166	3	ra	ra	PROPN
dpc-5172	166	4	dy	dy	VERB
dpc-5172	166	5	20	20	NUM
dpc-5172	166	6	01	01	NUM
dpc-5172	166	7	u	u	PROPN
dpc-5172	166	8	sa	sa	PROPN
dpc-5172	167	1	w	w	PROPN
dpc-5172	167	2	hi	hi	INTJ
dpc-5172	167	3	te	te	INTJ
dpc-5172	167	4	pa	pa	PROPN
dpc-5172	167	5	ti	ti	PROPN
dpc-5172	167	6	en	en	X
dpc-5172	167	7	ts	ts	X
dpc-5172	167	8	st	st	PROPN
dpc-5172	167	9	ud	ud	INTJ
dpc-5172	167	10	y	y	PROPN
dpc-5172	167	11	1	1	NUM
dpc-5172	167	12	:	:	SYM
dpc-5172	167	13	7	7	NUM
dpc-5172	167	14	7/	7/	NUM
dpc-5172	167	15	83	83	NUM
dpc-5172	167	16	st	st	NOUN
dpc-5172	167	17	ud	ud	INTJ
dpc-5172	167	18	y	y	PROPN
dpc-5172	167	19	2	2	NUM
dpc-5172	167	20	:	:	SYM
dpc-5172	167	21	8	8	NUM
dpc-5172	167	22	2/	2/	NUM
dpc-5172	167	23	86	86	NUM
dpc-5172	167	24	st	st	PROPN
dpc-5172	167	25	ud	ud	INTJ
dpc-5172	167	26	y	y	PROPN
dpc-5172	167	27	12	12	NUM
dpc-5172	167	28	:	:	PUNCT
dpc-5172	167	29	t	t	PROPN
dpc-5172	167	30	re	re	NOUN
dpc-5172	167	31	ti	ti	PROPN
dpc-5172	167	32	no	no	INTJ
dpc-5172	167	33	in	in	ADP
dpc-5172	167	34	0	0	NUM
dpc-5172	167	35	.	.	PUNCT
dpc-5172	168	1	02	02	NUM
dpc-5172	168	2	%	%	NOUN
dpc-5172	168	3	:	:	PUNCT
dpc-5172	168	4	7	7	NUM
dpc-5172	168	5	8/	8/	NUM
dpc-5172	168	6	12	12	NUM
dpc-5172	168	7	v	v	NOUN
dpc-5172	168	8	eh	eh	INTJ
dpc-5172	168	9	ic	ic	PROPN
dpc-5172	168	10	le	le	X
dpc-5172	168	11	:	:	PUNCT
dpc-5172	168	12	8	8	NUM
dpc-5172	168	13	0/	0/	NUM
dpc-5172	168	14	9	9	NUM
dpc-5172	168	15	s	s	PART
dpc-5172	168	16	tu	tu	X
dpc-5172	168	17	dy	dy	NOUN
dpc-5172	168	18	2	2	NUM
dpc-5172	168	19	2	2	NUM
dpc-5172	168	20	:	:	PUNCT
dpc-5172	168	21	t	t	PROPN
dpc-5172	168	22	re	re	NOUN
dpc-5172	168	23	ti	ti	PROPN
dpc-5172	168	24	no	no	INTJ
dpc-5172	168	25	in	in	ADP
dpc-5172	168	26	0	0	NUM
dpc-5172	168	27	.	.	PUNCT
dpc-5172	169	1	02	02	NUM
dpc-5172	169	2	%	%	NOUN
dpc-5172	169	3	:	:	PUNCT
dpc-5172	169	4	7	7	NUM
dpc-5172	169	5	9/	9/	NUM
dpc-5172	169	6	10	10	NUM
dpc-5172	169	7	v	v	INTJ
dpc-5172	169	8	eh	eh	INTJ
dpc-5172	169	9	ic	ic	PROPN
dpc-5172	169	10	le	le	X
dpc-5172	169	11	:	:	PUNCT
dpc-5172	169	12	8	8	NUM
dpc-5172	169	13	0/	0/	NUM
dpc-5172	169	14	10	10	NUM
dpc-5172	169	15	st	st	PROPN
dpc-5172	169	16	ud	ud	INTJ
dpc-5172	169	17	y	y	PROPN
dpc-5172	169	18	1	1	NUM
dpc-5172	169	19	:	:	SYM
dpc-5172	169	20	5	5	NUM
dpc-5172	169	21	8	8	NUM
dpc-5172	169	22	.	.	X
dpc-5172	169	23	4	4	NUM
dpc-5172	169	24	(	(	PUNCT
dpc-5172	169	25	4	4	NUM
dpc-5172	169	26	5	5	NUM
dpc-5172	169	27	–	–	PUNCT
dpc-5172	169	28	69	69	NUM
dpc-5172	169	29	)	)	PUNCT
dpc-5172	169	30	st	st	PROPN
dpc-5172	170	1	ud	ud	INTJ
dpc-5172	170	2	y	y	PROPN
dpc-5172	170	3	2	2	NUM
dpc-5172	170	4	:	:	SYM
dpc-5172	170	5	5	5	NUM
dpc-5172	170	6	8	8	NUM
dpc-5172	170	7	.	.	NOUN
dpc-5172	170	8	6	6	NUM
dpc-5172	170	9	(	(	PUNCT
dpc-5172	170	10	4	4	NUM
dpc-5172	170	11	3	3	NUM
dpc-5172	170	12	–	–	SYM
dpc-5172	170	13	70	70	NUM
dpc-5172	170	14	)	)	PUNCT
dpc-5172	170	15	r	r	NOUN
dpc-5172	170	16	c	c	PROPN
dpc-5172	170	17	t	t	PROPN
dpc-5172	170	18	,	,	PUNCT
dpc-5172	170	19	do	do	VERB
dpc-5172	170	20	ub	ub	X
dpc-5172	170	21	le	le	PROPN
dpc-5172	171	1	-b	-b	PUNCT
dpc-5172	171	2	lin	lin	PROPN
dpc-5172	171	3	d	d	PROPN
dpc-5172	171	4	n	n	PROPN
dpc-5172	171	5	ot	ot	INTJ
dpc-5172	171	6	m	m	VERB
dpc-5172	171	7	en	en	ADP
dpc-5172	171	8	ti	ti	NOUN
dpc-5172	171	9	on	on	ADP
dpc-5172	171	10	ed	ed	PROPN
dpc-5172	171	11	n	n	PROPN
dpc-5172	171	12	ot	ot	VERB
dpc-5172	171	13	m	m	VERB
dpc-5172	171	14	en	en	ADP
dpc-5172	171	15	ti	ti	NOUN
dpc-5172	171	16	on	on	ADP
dpc-5172	171	17	ed	ed	NOUN
dpc-5172	171	18	o	o	PROPN
dpc-5172	171	19	rt	rt	PROPN
dpc-5172	171	20	ho	ho	PROPN
dpc-5172	171	21	d	d	X
dpc-5172	171	22	er	er	INTJ
dpc-5172	171	23	m	m	VERB
dpc-5172	171	24	at	at	ADP
dpc-5172	171	25	ol	ol	PROPN
dpc-5172	171	26	og	og	PROPN
dpc-5172	171	27	ic	ic	PROPN
dpc-5172	171	28	al	al	PROPN
dpc-5172	171	29	d	d	PROPN
dpc-5172	171	30	iv	iv	PROPN
dpc-5172	171	31	is	be	AUX
dpc-5172	171	32	io	io	PROPN
dpc-5172	171	33	n	n	PROPN
dpc-5172	171	34	of	of	ADP
dpc-5172	171	35	o	o	PROPN
dpc-5172	171	36	rt	rt	PROPN
dpc-5172	172	1	ho	ho	PROPN
dpc-5172	173	1	m	m	VERB
dpc-5172	173	2	cn	cn	PROPN
dpc-5172	173	3	ei	ei	INTJ
dpc-5172	173	4	l	l	PROPN
dpc-5172	174	1	p	p	X
dpc-5172	174	2	ha	ha	INTJ
dpc-5172	174	3	rm	rm	PROPN
dpc-5172	174	4	ac	ac	PROPN
dpc-5172	174	5	eu	eu	PROPN
dpc-5172	174	6	ti	ti	PROPN
dpc-5172	174	7	ca	ca	NOUN
dpc-5172	174	8	l	l	NOUN
dpc-5172	174	9	,	,	PUNCT
dpc-5172	174	10	in	in	ADP
dpc-5172	174	11	c.	c.	PROPN
dpc-5172	174	12	k	k	PROPN
dpc-5172	175	1	an	an	DET
dpc-5172	175	2	g	g	PROPN
dpc-5172	175	3	20	20	NUM
dpc-5172	175	4	05	05	NUM
dpc-5172	175	5	u	u	PROPN
dpc-5172	175	6	sa	sa	PROPN
dpc-5172	175	7	h	h	PROPN
dpc-5172	175	8	ea	ea	PROPN
dpc-5172	175	9	lt	lt	PRON
dpc-5172	175	10	hy	hy	PROPN
dpc-5172	175	11	pa	pa	PROPN
dpc-5172	175	12	ti	ti	PROPN
dpc-5172	175	13	en	en	X
dpc-5172	175	14	ts	ts	ADP
dpc-5172	175	15	10	10	NUM
dpc-5172	175	16	1/	1/	NUM
dpc-5172	175	17	10	10	NUM
dpc-5172	175	18	3	3	NUM
dpc-5172	175	19	t	t	NOUN
dpc-5172	175	20	re	re	X
dpc-5172	175	21	ti	ti	PROPN
dpc-5172	175	22	no	no	INTJ
dpc-5172	175	23	in	in	ADP
dpc-5172	175	24	0	0	NUM
dpc-5172	175	25	.	.	PUNCT
dpc-5172	176	1	05	05	NUM
dpc-5172	176	2	%	%	NOUN
dpc-5172	176	3	:	:	PUNCT
dpc-5172	176	4	9	9	NUM
dpc-5172	176	5	1/	1/	NUM
dpc-5172	176	6	10	10	NUM
dpc-5172	176	7	v	v	NOUN
dpc-5172	176	8	eh	eh	INTJ
dpc-5172	176	9	ic	ic	PROPN
dpc-5172	176	10	le	le	X
dpc-5172	176	11	:	:	PUNCT
dpc-5172	176	12	9	9	NUM
dpc-5172	176	13	2/	2/	NUM
dpc-5172	176	14	11	11	NUM
dpc-5172	176	15	t	t	NOUN
dpc-5172	176	16	re	re	X
dpc-5172	176	17	ti	ti	PROPN
dpc-5172	176	18	no	no	INTJ
dpc-5172	176	19	in	in	ADP
dpc-5172	176	20	:	:	PUNCT
dpc-5172	176	21	63	63	NUM
dpc-5172	176	22	.2	.2	NUM
dpc-5172	176	23	(	(	PUNCT
dpc-5172	176	24	4	4	NUM
dpc-5172	176	25	0	0	NUM
dpc-5172	176	26	–	–	PUNCT
dpc-5172	176	27	76	76	NUM
dpc-5172	176	28	)	)	PUNCT
dpc-5172	176	29	v	v	ADP
dpc-5172	176	30	eh	eh	INTJ
dpc-5172	176	31	ic	ic	PROPN
dpc-5172	176	32	le	le	X
dpc-5172	176	33	:	:	PUNCT
dpc-5172	176	34	62	62	NUM
dpc-5172	176	35	.4	.4	NUM
dpc-5172	176	36	(	(	PUNCT
dpc-5172	176	37	4	4	NUM
dpc-5172	176	38	3	3	NUM
dpc-5172	176	39	–	–	PUNCT
dpc-5172	176	40	75	75	NUM
dpc-5172	176	41	)	)	PUNCT
dpc-5172	176	42	r	r	NOUN
dpc-5172	176	43	c	c	PROPN
dpc-5172	176	44	t	t	PROPN
dpc-5172	176	45	,	,	PUNCT
dpc-5172	176	46	do	do	VERB
dpc-5172	176	47	ub	ub	X
dpc-5172	176	48	le	le	PROPN
dpc-5172	177	1	-b	-b	PUNCT
dpc-5172	177	2	lin	lin	PROPN
dpc-5172	177	3	d	d	PROPN
dpc-5172	177	4	n	n	PROPN
dpc-5172	177	5	ot	ot	INTJ
dpc-5172	177	6	m	m	VERB
dpc-5172	177	7	en	en	ADP
dpc-5172	177	8	ti	ti	NOUN
dpc-5172	177	9	on	on	ADP
dpc-5172	177	10	ed	ed	PROPN
dpc-5172	177	11	c	c	PROPN
dpc-5172	177	12	om	om	PROPN
dpc-5172	177	13	pu	pu	PROPN
dpc-5172	177	14	te	te	PROPN
dpc-5172	177	15	rge	rge	PROPN
dpc-5172	177	16	ne	ne	X
dpc-5172	177	17	ra	ra	PROPN
dpc-5172	178	1	te	te	PROPN
dpc-5172	178	2	d	d	X
dpc-5172	178	3	ra	ra	PROPN
dpc-5172	178	4	nd	nd	INTJ
dpc-5172	178	5	om	om	PROPN
dpc-5172	178	6	iz	iz	INTJ
dpc-5172	178	7	at	at	ADP
dpc-5172	178	8	io	io	PROPN
dpc-5172	178	9	n	n	DET
dpc-5172	178	10	lis	li	NOUN
dpc-5172	178	11	ts	ts	ADP
dpc-5172	178	12	o	o	PROPN
dpc-5172	178	13	rt	rt	PROPN
dpc-5172	178	14	ho	ho	PROPN
dpc-5172	178	15	n	n	CCONJ
dpc-5172	178	16	eu	eu	PROPN
dpc-5172	178	17	tr	tr	PROPN
dpc-5172	178	18	og	og	PROPN
dpc-5172	178	19	en	en	PROPN
dpc-5172	178	20	a	a	DET
dpc-5172	178	21	w	w	NOUN
dpc-5172	178	22	ei	ei	NOUN
dpc-5172	178	23	ss	ss	ADP
dpc-5172	178	24	2	2	NUM
dpc-5172	178	25	00	00	NUM
dpc-5172	178	26	6	6	NUM
dpc-5172	178	27	u	u	PROPN
dpc-5172	178	28	sa	sa	PROPN
dpc-5172	178	29	h	h	PROPN
dpc-5172	178	30	ea	ea	PROPN
dpc-5172	179	1	lt	lt	PRON
dpc-5172	179	2	hy	hy	PROPN
dpc-5172	180	1	w	w	PROPN
dpc-5172	180	2	hi	hi	INTJ
dpc-5172	180	3	te	te	INTJ
dpc-5172	180	4	pa	pa	PROPN
dpc-5172	180	5	ti	ti	PROPN
dpc-5172	180	6	en	en	X
dpc-5172	180	7	ts	ts	ADP
dpc-5172	180	8	22	22	NUM
dpc-5172	180	9	/2	/2	NUM
dpc-5172	180	10	3	3	NUM
dpc-5172	180	11	to	to	ADP
dpc-5172	180	12	ta	ta	ADP
dpc-5172	180	13	l	l	NOUN
dpc-5172	180	14	:	:	PUNCT
dpc-5172	180	15	44	44	NUM
dpc-5172	180	16	/1	/1	NOUN
dpc-5172	180	17	(	(	PUNCT
dpc-5172	180	18	3	3	NUM
dpc-5172	180	19	8	8	NUM
dpc-5172	180	20	–	–	PUNCT
dpc-5172	180	21	73	73	NUM
dpc-5172	180	22	)	)	PUNCT
dpc-5172	180	23	r	r	NOUN
dpc-5172	180	24	c	c	PROPN
dpc-5172	180	25	t	t	PROPN
dpc-5172	180	26	,	,	PUNCT
dpc-5172	180	27	do	do	VERB
dpc-5172	180	28	ub	ub	X
dpc-5172	180	29	le	le	PROPN
dpc-5172	181	1	-b	-b	PUNCT
dpc-5172	181	2	lin	lin	PROPN
dpc-5172	181	3	d	d	PROPN
dpc-5172	181	4	n	n	PROPN
dpc-5172	181	5	ot	ot	INTJ
dpc-5172	181	6	m	m	VERB
dpc-5172	181	7	en	en	ADP
dpc-5172	181	8	ti	ti	NOUN
dpc-5172	181	9	on	on	ADP
dpc-5172	181	10	ed	ed	PROPN
dpc-5172	181	11	n	n	PROPN
dpc-5172	181	12	ot	ot	VERB
dpc-5172	181	13	m	m	VERB
dpc-5172	181	14	en	en	ADP
dpc-5172	181	15	ti	ti	NOUN
dpc-5172	181	16	on	on	ADP
dpc-5172	181	17	ed	ed	NOUN
dpc-5172	181	18	o	o	PROPN
dpc-5172	181	19	rt	rt	PROPN
dpc-5172	181	20	ho	ho	PROPN
dpc-5172	181	21	n	n	CCONJ
dpc-5172	181	22	eu	eu	PROPN
dpc-5172	181	23	tr	tr	PROPN
dpc-5172	181	24	og	og	PROPN
dpc-5172	181	25	en	en	PROPN
dpc-5172	181	26	a	a	DET
dpc-5172	181	27	r	r	NOUN
dpc-5172	181	28	c	c	NOUN
dpc-5172	181	29	t	t	NOUN
dpc-5172	181	30	:	:	PUNCT
dpc-5172	181	31	r	r	NOUN
dpc-5172	181	32	an	an	DET
dpc-5172	181	33	do	do	NOUN
dpc-5172	181	34	m	m	NOUN
dpc-5172	181	35	iz	iz	INTJ
dpc-5172	182	1	ed	ed	NOUN
dpc-5172	182	2	c	c	PROPN
dpc-5172	182	3	on	on	ADP
dpc-5172	182	4	tr	tr	VERB
dpc-5172	182	5	ol	ol	PROPN
dpc-5172	182	6	le	le	X
dpc-5172	182	7	d	d	PROPN
dpc-5172	182	8	tr	tr	PROPN
dpc-5172	182	9	ia	ia	PROPN
dpc-5172	182	10	l.	l.	PROPN
dpc-5172	182	11	u	u	PROPN
dpc-5172	182	12	sa	sa	PROPN
dpc-5172	182	13	:	:	PUNCT
dpc-5172	182	14	u	u	PROPN
dpc-5172	182	15	ni	ni	PROPN
dpc-5172	182	16	te	te	PROPN
dpc-5172	182	17	d	d	PROPN
dpc-5172	182	18	st	st	PROPN
dpc-5172	182	19	at	at	ADP
dpc-5172	182	20	es	es	X
dpc-5172	182	21	o	o	PROPN
dpc-5172	182	22	f	f	PROPN
dpc-5172	183	1	a	a	PRON
dpc-5172	183	2	m	m	VERB
dpc-5172	183	3	er	er	INTJ
dpc-5172	183	4	ic	ic	NOUN
dpc-5172	183	5	a.	a.	NOUN
dpc-5172	183	6	1	1	PROPN
dpc-5172	183	7	a	a	DET
dpc-5172	183	8	ge	ge	PROPN
dpc-5172	183	9	is	be	AUX
dpc-5172	183	10	p	p	ADJ
dpc-5172	183	11	re	re	X
dpc-5172	183	12	se	se	X
dpc-5172	183	13	nt	not	PART
dpc-5172	183	14	ed	ed	VERB
dpc-5172	183	15	a	a	DET
dpc-5172	183	16	s	s	NOUN
dpc-5172	183	17	m	m	NOUN
dpc-5172	183	18	ea	ea	NOUN
dpc-5172	183	19	ns	ns	NUM
dpc-5172	184	1	(	(	PUNCT
dpc-5172	184	2	ra	ra	INTJ
dpc-5172	184	3	ng	ng	PROPN
dpc-5172	184	4	es	es	PROPN
dpc-5172	184	5	)	)	PUNCT
dpc-5172	184	6	or	or	CCONJ
dpc-5172	184	7	a	a	DET
dpc-5172	184	8	s	s	X
dpc-5172	184	9	(	(	PUNCT
dpc-5172	184	10	r	r	NOUN
dpc-5172	184	11	an	an	DET
dpc-5172	184	12	ge	ge	PROPN
dpc-5172	184	13	s	s	PART
dpc-5172	184	14	)	)	PUNCT
dpc-5172	184	15	o	o	NOUN
dpc-5172	185	1	nl	nl	PROPN
dpc-5172	185	2	y.	y.	PROPN
dpc-5172	185	3	2	2	NUM
dpc-5172	185	4	se	se	X
dpc-5172	185	5	x	x	PROPN
dpc-5172	186	1	w	w	NOUN
dpc-5172	186	2	as	as	ADP
dpc-5172	186	3	a	a	DET
dpc-5172	186	4	ss	ss	NOUN
dpc-5172	186	5	es	es	X
dpc-5172	186	6	se	se	PROPN
dpc-5172	186	7	d	d	PROPN
dpc-5172	186	8	in	in	ADP
dpc-5172	186	9	s	s	NOUN
dpc-5172	186	10	tu	tu	X
dpc-5172	186	11	di	di	X
dpc-5172	186	12	es	es	X
dpc-5172	186	13	e	e	PROPN
dpc-5172	186	14	va	va	PROPN
dpc-5172	186	15	lu	lu	PROPN
dpc-5172	186	16	at	at	ADP
dpc-5172	186	17	in	in	ADP
dpc-5172	186	18	g	g	PROPN
dpc-5172	186	19	sa	sa	PROPN
dpc-5172	186	20	fe	fe	PROPN
dpc-5172	186	21	ty	ty	INTJ
dpc-5172	186	22	in	in	ADP
dpc-5172	186	23	st	st	PROPN
dpc-5172	186	24	ea	ea	PROPN
dpc-5172	186	25	d	d	PROPN
dpc-5172	186	26	of	of	ADP
dpc-5172	186	27	e	e	PROPN
dpc-5172	186	28	ff	ff	NOUN
dpc-5172	186	29	ic	ic	PROPN
dpc-5172	186	30	ac	ac	PROPN
dpc-5172	186	31	y.	y.	PROPN
dpc-5172	186	32	6	6	NUM
dpc-5172	186	33	review	review	NOUN
dpc-5172	186	34	|	|	ADV
dpc-5172	186	35	dermatol	dermatol	ADJ
dpc-5172	186	36	pract	pract	NOUN
dpc-5172	186	37	concept	concept	NOUN
dpc-5172	186	38	.	.	PUNCT
dpc-5172	187	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	187	2	s6	s6	PROPN
dpc-5172	187	3	)	)	PUNCT
dpc-5172	187	4	.	.	PUNCT
dpc-5172	188	1	no	no	DET
dpc-5172	188	2	significant	significant	ADJ
dpc-5172	188	3	heterogeneity	heterogeneity	NOUN
dpc-5172	188	4	was	be	AUX
dpc-5172	188	5	observed	observe	VERB
dpc-5172	188	6	among	among	ADP
dpc-5172	188	7	the	the	DET
dpc-5172	188	8	trials	trial	NOUN
dpc-5172	188	9	.	.	PUNCT
dpc-5172	189	1	additionally	additionally	ADV
dpc-5172	189	2	,	,	PUNCT
dpc-5172	189	3	egger	egger	NOUN
dpc-5172	189	4	’s	’s	PART
dpc-5172	189	5	test	test	NOUN
dpc-5172	189	6	revealed	reveal	VERB
dpc-5172	189	7	no	no	DET
dpc-5172	189	8	significant	significant	ADJ
dpc-5172	189	9	publication	publication	NOUN
dpc-5172	189	10	bias	bias	NOUN
dpc-5172	189	11	in	in	ADP
dpc-5172	189	12	studies	study	NOUN
dpc-5172	189	13	evaluating	evaluate	VERB
dpc-5172	189	14	patient	patient	ADJ
dpc-5172	189	15	self	self	NOUN
dpc-5172	189	16	-	-	PUNCT
dpc-5172	189	17	assessments	assessment	NOUN
dpc-5172	189	18	(	(	PUNCT
dpc-5172	189	19	p=0.284	p=0.284	NUM
dpc-5172	189	20	;	;	PUNCT
dpc-5172	189	21	figure	figure	NOUN
dpc-5172	189	22	s7	s7	NOUN
dpc-5172	189	23	)	)	PUNCT
dpc-5172	189	24	.	.	PUNCT
dpc-5172	190	1	tertiary	tertiary	ADJ
dpc-5172	190	2	outcome	outcome	NOUN
dpc-5172	190	3	:	:	PUNCT
dpc-5172	190	4	adverse	adverse	ADJ
dpc-5172	190	5	event	event	NOUN
dpc-5172	190	6	rates	rate	NOUN
dpc-5172	190	7	associated	associate	VERB
dpc-5172	190	8	with	with	ADP
dpc-5172	190	9	treatment	treatment	NOUN
dpc-5172	190	10	among	among	ADP
dpc-5172	190	11	the	the	DET
dpc-5172	190	12	1,361	1,361	NUM
dpc-5172	190	13	patients	patient	NOUN
dpc-5172	190	14	included	include	VERB
dpc-5172	190	15	in	in	ADP
dpc-5172	190	16	the	the	DET
dpc-5172	190	17	trials	trial	NOUN
dpc-5172	190	18	,	,	PUNCT
dpc-5172	190	19	822	822	NUM
dpc-5172	190	20	received	receive	VERB
dpc-5172	190	21	tretinoin	tretinoin	NOUN
dpc-5172	190	22	treatment	treatment	NOUN
dpc-5172	190	23	.	.	PUNCT
dpc-5172	191	1	a	a	DET
dpc-5172	191	2	total	total	NOUN
dpc-5172	191	3	of	of	ADP
dpc-5172	191	4	492	492	NUM
dpc-5172	191	5	treatment	treatment	NOUN
dpc-5172	191	6	-	-	PUNCT
dpc-5172	191	7	related	relate	VERB
dpc-5172	191	8	adverse	adverse	ADJ
dpc-5172	191	9	events	event	NOUN
dpc-5172	191	10	were	be	AUX
dpc-5172	191	11	reported	report	VERB
dpc-5172	191	12	in	in	ADP
dpc-5172	191	13	this	this	DET
dpc-5172	191	14	group	group	NOUN
dpc-5172	191	15	.	.	PUNCT
dpc-5172	192	1	meta	meta	ADJ
dpc-5172	192	2	-	-	PUNCT
dpc-5172	192	3	analysis	analysis	NOUN
dpc-5172	192	4	of	of	ADP
dpc-5172	192	5	adverse	adverse	ADJ
dpc-5172	192	6	event	event	NOUN
dpc-5172	192	7	rates	rate	NOUN
dpc-5172	192	8	revealed	reveal	VERB
dpc-5172	192	9	a	a	DET
dpc-5172	192	10	significant	significant	ADJ
dpc-5172	192	11	increase	increase	NOUN
dpc-5172	192	12	in	in	ADP
dpc-5172	192	13	the	the	DET
dpc-5172	192	14	likelihood	likelihood	NOUN
dpc-5172	192	15	of	of	ADP
dpc-5172	192	16	experiencing	experience	VERB
dpc-5172	192	17	adverse	adverse	ADJ
dpc-5172	192	18	events	event	NOUN
dpc-5172	192	19	following	follow	VERB
dpc-5172	192	20	tretinoin	tretinoin	PROPN
dpc-5172	192	21	treatment	treatment	NOUN
dpc-5172	192	22	secondary	secondary	ADJ
dpc-5172	192	23	outcome	outcome	NOUN
dpc-5172	192	24	:	:	PUNCT
dpc-5172	192	25	patient	patient	ADJ
dpc-5172	192	26	self	self	NOUN
dpc-5172	192	27	-	-	PUNCT
dpc-5172	192	28	assessments	assessment	NOUN
dpc-5172	192	29	of	of	ADP
dpc-5172	192	30	overall	overall	ADJ
dpc-5172	192	31	improvement	improvement	NOUN
dpc-5172	192	32	in	in	ADP
dpc-5172	192	33	photodamage	photodamage	NOUN
dpc-5172	192	34	severity	severity	NOUN
dpc-5172	192	35	of	of	ADP
dpc-5172	192	36	facial	facial	ADJ
dpc-5172	192	37	skin	skin	NOUN
dpc-5172	192	38	after	after	ADP
dpc-5172	192	39	treatment	treatment	NOUN
dpc-5172	192	40	with	with	ADP
dpc-5172	192	41	tretinoin	tretinoin	NOUN
dpc-5172	192	42	compared	compare	VERB
dpc-5172	192	43	with	with	ADP
dpc-5172	192	44	a	a	DET
dpc-5172	192	45	vehicle	vehicle	NOUN
dpc-5172	192	46	six	six	NUM
dpc-5172	192	47	of	of	ADP
dpc-5172	192	48	the	the	DET
dpc-5172	192	49	eight	eight	NUM
dpc-5172	192	50	included	include	VERB
dpc-5172	192	51	trials	trial	NOUN
dpc-5172	192	52	reported	report	VERB
dpc-5172	192	53	data	datum	NOUN
dpc-5172	192	54	on	on	ADP
dpc-5172	192	55	patient	patient	ADJ
dpc-5172	192	56	self	self	NOUN
dpc-5172	192	57	-	-	PUNCT
dpc-5172	192	58	assessments	assessment	NOUN
dpc-5172	192	59	of	of	ADP
dpc-5172	192	60	overall	overall	ADJ
dpc-5172	192	61	improvement	improvement	NOUN
dpc-5172	192	62	in	in	ADP
dpc-5172	192	63	photoaging	photoage	VERB
dpc-5172	192	64	,	,	PUNCT
dpc-5172	192	65	including	include	VERB
dpc-5172	192	66	with	with	ADP
dpc-5172	192	67	respect	respect	NOUN
dpc-5172	192	68	to	to	ADP
dpc-5172	192	69	skin	skin	NOUN
dpc-5172	192	70	appearance	appearance	NOUN
dpc-5172	192	71	and	and	CCONJ
dpc-5172	192	72	texture	texture	NOUN
dpc-5172	192	73	,	,	PUNCT
dpc-5172	192	74	following	follow	VERB
dpc-5172	192	75	treatment	treatment	NOUN
dpc-5172	192	76	with	with	ADP
dpc-5172	192	77	tretinoin	tretinoin	NOUN
dpc-5172	192	78	compared	compare	VERB
dpc-5172	192	79	with	with	ADP
dpc-5172	192	80	a	a	DET
dpc-5172	192	81	vehicle	vehicle	NOUN
dpc-5172	192	82	[	[	X
dpc-5172	192	83	2,5	2,5	NUM
dpc-5172	192	84	-	-	SYM
dpc-5172	192	85	8,19	8,19	NUM
dpc-5172	192	86	]	]	PUNCT
dpc-5172	192	87	.	.	PUNCT
dpc-5172	193	1	patients	patient	NOUN
dpc-5172	193	2	who	who	PRON
dpc-5172	193	3	received	receive	VERB
dpc-5172	193	4	tretinoin	tretinoin	NOUN
dpc-5172	193	5	provided	provide	VERB
dpc-5172	193	6	significantly	significantly	ADV
dpc-5172	193	7	higher	high	ADJ
dpc-5172	193	8	ratings	rating	NOUN
dpc-5172	193	9	for	for	ADP
dpc-5172	193	10	overall	overall	ADJ
dpc-5172	193	11	improvement	improvement	NOUN
dpc-5172	193	12	(	(	PUNCT
dpc-5172	193	13	md	md	PROPN
dpc-5172	193	14	:	:	PUNCT
dpc-5172	193	15	0.270	0.270	NUM
dpc-5172	193	16	;	;	PUNCT
dpc-5172	193	17	95	95	NUM
dpc-5172	193	18	%	%	NOUN
dpc-5172	193	19	ci	ci	NOUN
dpc-5172	193	20	:	:	PUNCT
dpc-5172	193	21	0.033–0.508	0.033–0.508	NUM
dpc-5172	193	22	;	;	PUNCT
dpc-5172	193	23	p=0.026	p=0.026	X
dpc-5172	193	24	;	;	PUNCT
dpc-5172	193	25	i²=0	i²=0	NOUN
dpc-5172	193	26	%	%	NOUN
dpc-5172	193	27	;	;	PUNCT
dpc-5172	193	28	figure	figure	NOUN
dpc-5172	193	29	s5	s5	PROPN
dpc-5172	193	30	)	)	PUNCT
dpc-5172	193	31	.	.	PUNCT
dpc-5172	194	1	the	the	DET
dpc-5172	194	2	sensitivity	sensitivity	NOUN
dpc-5172	194	3	analysis	analysis	NOUN
dpc-5172	194	4	revealed	reveal	VERB
dpc-5172	194	5	consistent	consistent	ADJ
dpc-5172	194	6	results	result	NOUN
dpc-5172	194	7	(	(	PUNCT
dpc-5172	194	8	p=0.026	p=0.026	NUM
dpc-5172	194	9	;	;	PUNCT
dpc-5172	194	10	figure	figure	NOUN
dpc-5172	194	11	figure	figure	NOUN
dpc-5172	194	12	2	2	NUM
dpc-5172	194	13	.	.	PUNCT
dpc-5172	194	14	forest	forest	NOUN
dpc-5172	194	15	plot	plot	NOUN
dpc-5172	194	16	illustrating	illustrate	VERB
dpc-5172	194	17	the	the	DET
dpc-5172	194	18	effects	effect	NOUN
dpc-5172	194	19	of	of	ADP
dpc-5172	194	20	topical	topical	ADJ
dpc-5172	194	21	tretinoin	tretinoin	NOUN
dpc-5172	194	22	on	on	ADP
dpc-5172	194	23	fine	fine	ADJ
dpc-5172	194	24	wrinkles	wrinkle	NOUN
dpc-5172	194	25	on	on	ADP
dpc-5172	194	26	photodamaged	photodamage	VERB
dpc-5172	194	27	facial	facial	ADJ
dpc-5172	194	28	skin	skin	NOUN
dpc-5172	194	29	compared	compare	VERB
dpc-5172	194	30	with	with	ADP
dpc-5172	194	31	placebo	placebo	NOUN
dpc-5172	194	32	(	(	PUNCT
dpc-5172	194	33	vehicle	vehicle	NOUN
dpc-5172	194	34	)	)	PUNCT
dpc-5172	194	35	.	.	PUNCT
dpc-5172	195	1	this	this	DET
dpc-5172	195	2	figure	figure	NOUN
dpc-5172	195	3	summarizes	summarize	VERB
dpc-5172	195	4	the	the	DET
dpc-5172	195	5	results	result	NOUN
dpc-5172	195	6	of	of	ADP
dpc-5172	195	7	clinical	clinical	ADJ
dpc-5172	195	8	studies	study	NOUN
dpc-5172	195	9	evaluating	evaluate	VERB
dpc-5172	195	10	the	the	DET
dpc-5172	195	11	effectiveness	effectiveness	NOUN
dpc-5172	195	12	of	of	ADP
dpc-5172	195	13	tretinoin	tretinoin	NOUN
dpc-5172	195	14	,	,	PUNCT
dpc-5172	195	15	a	a	DET
dpc-5172	195	16	topical	topical	ADJ
dpc-5172	195	17	retinoid	retinoid	NOUN
dpc-5172	195	18	,	,	PUNCT
dpc-5172	195	19	in	in	ADP
dpc-5172	195	20	reducing	reduce	VERB
dpc-5172	195	21	fine	fine	ADJ
dpc-5172	195	22	facial	facial	ADJ
dpc-5172	195	23	wrinkles	wrinkle	NOUN
dpc-5172	195	24	caused	cause	VERB
dpc-5172	195	25	by	by	ADP
dpc-5172	195	26	sun	sun	NOUN
dpc-5172	195	27	damage	damage	NOUN
dpc-5172	195	28	.	.	PUNCT
dpc-5172	196	1	the	the	DET
dpc-5172	196	2	plot	plot	NOUN
dpc-5172	196	3	reveals	reveal	VERB
dpc-5172	196	4	that	that	SCONJ
dpc-5172	196	5	tretinoin	tretinoin	PROPN
dpc-5172	196	6	led	lead	VERB
dpc-5172	196	7	to	to	ADP
dpc-5172	196	8	a	a	DET
dpc-5172	196	9	significantly	significantly	ADV
dpc-5172	196	10	greater	great	ADJ
dpc-5172	196	11	improvement	improvement	NOUN
dpc-5172	196	12	in	in	ADP
dpc-5172	196	13	wrinkle	wrinkle	NOUN
dpc-5172	196	14	appearance	appearance	NOUN
dpc-5172	196	15	than	than	SCONJ
dpc-5172	196	16	the	the	DET
dpc-5172	196	17	placebo	placebo	NOUN
dpc-5172	196	18	treatment	treatment	NOUN
dpc-5172	196	19	did	do	VERB
dpc-5172	196	20	.	.	PUNCT
dpc-5172	197	1	(	(	PUNCT
dpc-5172	197	2	ci	ci	NOUN
dpc-5172	197	3	=	=	NOUN
dpc-5172	197	4	confidence	confidence	NOUN
dpc-5172	197	5	interval	interval	NOUN
dpc-5172	197	6	;	;	PUNCT
dpc-5172	197	7	f	f	PROPN
dpc-5172	197	8	=	=	SYM
dpc-5172	197	9	fine	fine	ADJ
dpc-5172	197	10	wrinkles	wrinkles	PROPN
dpc-5172	197	11	)	)	PUNCT
dpc-5172	197	12	figure	figure	NOUN
dpc-5172	197	13	3	3	NUM
dpc-5172	197	14	.	.	PUNCT
dpc-5172	197	15	forest	forest	NOUN
dpc-5172	197	16	plot	plot	NOUN
dpc-5172	197	17	illustrating	illustrate	VERB
dpc-5172	197	18	the	the	DET
dpc-5172	197	19	effects	effect	NOUN
dpc-5172	197	20	of	of	ADP
dpc-5172	197	21	topical	topical	ADJ
dpc-5172	197	22	tretinoin	tretinoin	NOUN
dpc-5172	197	23	on	on	ADP
dpc-5172	197	24	coarse	coarse	ADJ
dpc-5172	197	25	wrinkles	wrinkle	NOUN
dpc-5172	197	26	in	in	ADP
dpc-5172	197	27	photodamaged	photodamage	VERB
dpc-5172	197	28	facial	facial	ADJ
dpc-5172	197	29	skin	skin	NOUN
dpc-5172	197	30	compared	compare	VERB
dpc-5172	197	31	with	with	ADP
dpc-5172	197	32	placebo	placebo	NOUN
dpc-5172	197	33	(	(	PUNCT
dpc-5172	197	34	vehicle	vehicle	NOUN
dpc-5172	197	35	)	)	PUNCT
dpc-5172	197	36	.	.	PUNCT
dpc-5172	198	1	this	this	DET
dpc-5172	198	2	figure	figure	NOUN
dpc-5172	198	3	summarizes	summarize	VERB
dpc-5172	198	4	the	the	DET
dpc-5172	198	5	results	result	NOUN
dpc-5172	198	6	of	of	ADP
dpc-5172	198	7	clinical	clinical	ADJ
dpc-5172	198	8	studies	study	NOUN
dpc-5172	198	9	evaluating	evaluate	VERB
dpc-5172	198	10	the	the	DET
dpc-5172	198	11	effectiveness	effectiveness	NOUN
dpc-5172	198	12	of	of	ADP
dpc-5172	198	13	tretinoin	tretinoin	NOUN
dpc-5172	198	14	,	,	PUNCT
dpc-5172	198	15	a	a	DET
dpc-5172	198	16	topical	topical	ADJ
dpc-5172	198	17	retinoid	retinoid	NOUN
dpc-5172	198	18	,	,	PUNCT
dpc-5172	198	19	in	in	ADP
dpc-5172	198	20	reducing	reduce	VERB
dpc-5172	198	21	coarse	coarse	ADJ
dpc-5172	198	22	facial	facial	ADJ
dpc-5172	198	23	wrinkles	wrinkle	NOUN
dpc-5172	198	24	caused	cause	VERB
dpc-5172	198	25	by	by	ADP
dpc-5172	198	26	sun	sun	NOUN
dpc-5172	198	27	damage	damage	NOUN
dpc-5172	198	28	.	.	PUNCT
dpc-5172	199	1	the	the	DET
dpc-5172	199	2	plot	plot	NOUN
dpc-5172	199	3	reveals	reveal	VERB
dpc-5172	199	4	that	that	SCONJ
dpc-5172	199	5	tretinoin	tretinoin	PROPN
dpc-5172	199	6	led	lead	VERB
dpc-5172	199	7	to	to	ADP
dpc-5172	199	8	a	a	DET
dpc-5172	199	9	significantly	significantly	ADV
dpc-5172	199	10	greater	great	ADJ
dpc-5172	199	11	improvement	improvement	NOUN
dpc-5172	199	12	in	in	ADP
dpc-5172	199	13	wrinkle	wrinkle	NOUN
dpc-5172	199	14	appearance	appearance	NOUN
dpc-5172	199	15	than	than	SCONJ
dpc-5172	199	16	the	the	DET
dpc-5172	199	17	placebo	placebo	NOUN
dpc-5172	199	18	treatment	treatment	NOUN
dpc-5172	199	19	did	do	VERB
dpc-5172	199	20	(	(	PUNCT
dpc-5172	199	21	c	c	NOUN
dpc-5172	199	22	=	=	PUNCT
dpc-5172	199	23	coarse	coarse	NOUN
dpc-5172	199	24	wrinkles	wrinkle	NOUN
dpc-5172	199	25	;	;	PUNCT
dpc-5172	200	1	ci	ci	NOUN
dpc-5172	200	2	=	=	NOUN
dpc-5172	200	3	confidence	confidence	NOUN
dpc-5172	200	4	interval	interval	NOUN
dpc-5172	200	5	)	)	PUNCT
dpc-5172	200	6	.	.	PUNCT
dpc-5172	201	1	review	review	VERB
dpc-5172	201	2	|	|	ADV
dpc-5172	201	3	dermatol	dermatol	ADJ
dpc-5172	201	4	pract	pract	NOUN
dpc-5172	201	5	concept	concept	NOUN
dpc-5172	201	6	.	.	PUNCT
dpc-5172	202	1	2025;15(4):5172	2025;15(4):5172	NOUN
dpc-5172	202	2	7	7	NUM
dpc-5172	202	3	predominant	predominant	ADJ
dpc-5172	202	4	isoform	isoform	NOUN
dpc-5172	202	5	in	in	ADP
dpc-5172	202	6	human	human	ADJ
dpc-5172	202	7	skin	skin	NOUN
dpc-5172	202	8	[	[	X
dpc-5172	202	9	21	21	NUM
dpc-5172	202	10	]	]	PUNCT
dpc-5172	202	11	.	.	PUNCT
dpc-5172	203	1	the	the	DET
dpc-5172	203	2	binding	binding	NOUN
dpc-5172	203	3	of	of	ADP
dpc-5172	203	4	tretinoin	tretinoin	NOUN
dpc-5172	203	5	to	to	ADP
dpc-5172	203	6	rars	rar	NOUN
dpc-5172	203	7	triggers	trigger	VERB
dpc-5172	203	8	a	a	DET
dpc-5172	203	9	cascade	cascade	NOUN
dpc-5172	203	10	of	of	ADP
dpc-5172	203	11	gene	gene	NOUN
dpc-5172	203	12	expression	expression	NOUN
dpc-5172	203	13	that	that	PRON
dpc-5172	203	14	regulates	regulate	VERB
dpc-5172	203	15	keratinocyte	keratinocyte	NOUN
dpc-5172	203	16	proliferation	proliferation	NOUN
dpc-5172	203	17	and	and	CCONJ
dpc-5172	203	18	differentiation	differentiation	NOUN
dpc-5172	203	19	[	[	X
dpc-5172	203	20	21	21	NUM
dpc-5172	203	21	]	]	PUNCT
dpc-5172	203	22	.	.	PUNCT
dpc-5172	204	1	animal	animal	NOUN
dpc-5172	204	2	studies	study	NOUN
dpc-5172	204	3	have	have	AUX
dpc-5172	204	4	demonstrated	demonstrate	VERB
dpc-5172	204	5	that	that	SCONJ
dpc-5172	204	6	rar	rar	NOUN
dpc-5172	204	7	-	-	PUNCT
dpc-5172	204	8	γ	γ	NOUN
dpc-5172	204	9	activity	activity	NOUN
dpc-5172	204	10	,	,	PUNCT
dpc-5172	204	11	in	in	ADP
dpc-5172	204	12	coordination	coordination	NOUN
dpc-5172	204	13	with	with	ADP
dpc-5172	204	14	retinoid	retinoid	NOUN
dpc-5172	204	15	x	x	SYM
dpc-5172	204	16	receptor	receptor	NOUN
dpc-5172	204	17	alpha	alpha	NOUN
dpc-5172	204	18	(	(	PUNCT
dpc-5172	204	19	rxrα	rxrα	NOUN
dpc-5172	204	20	)	)	PUNCT
dpc-5172	204	21	,	,	PUNCT
dpc-5172	204	22	is	be	AUX
dpc-5172	204	23	essential	essential	ADJ
dpc-5172	204	24	to	to	ADP
dpc-5172	204	25	tretinoin	tretinoin	NOUN
dpc-5172	204	26	-	-	PUNCT
dpc-5172	204	27	induced	induce	VERB
dpc-5172	204	28	epidermal	epidermal	ADJ
dpc-5172	204	29	thickening	thickening	NOUN
dpc-5172	204	30	[	[	X
dpc-5172	204	31	22	22	NUM
dpc-5172	204	32	]	]	PUNCT
dpc-5172	204	33	.	.	PUNCT
dpc-5172	205	1	several	several	ADJ
dpc-5172	205	2	molecular	molecular	ADJ
dpc-5172	205	3	biomarkers	biomarker	NOUN
dpc-5172	205	4	have	have	AUX
dpc-5172	205	5	been	be	AUX
dpc-5172	205	6	identified	identify	VERB
dpc-5172	205	7	as	as	ADP
dpc-5172	205	8	potential	potential	ADJ
dpc-5172	205	9	predictors	predictor	NOUN
dpc-5172	205	10	of	of	ADP
dpc-5172	205	11	treatment	treatment	NOUN
dpc-5172	205	12	response	response	NOUN
dpc-5172	205	13	,	,	PUNCT
dpc-5172	205	14	including	include	VERB
dpc-5172	205	15	rar	rar	NOUN
dpc-5172	205	16	-	-	PUNCT
dpc-5172	205	17	γ	γ	NOUN
dpc-5172	205	18	expression	expression	NOUN
dpc-5172	205	19	,	,	PUNCT
dpc-5172	205	20	ki-67	ki-67	PRON
dpc-5172	205	21	,	,	PUNCT
dpc-5172	205	22	and	and	CCONJ
dpc-5172	205	23	epidermal	epidermal	ADJ
dpc-5172	205	24	growth	growth	NOUN
dpc-5172	205	25	factor	factor	NOUN
dpc-5172	205	26	receptor	receptor	NOUN
dpc-5172	205	27	(	(	PUNCT
dpc-5172	205	28	egfr	egfr	ADJ
dpc-5172	205	29	)	)	PUNCT
dpc-5172	205	30	pathway	pathway	NOUN
dpc-5172	205	31	activation	activation	NOUN
dpc-5172	205	32	.	.	PUNCT
dpc-5172	206	1	ki-67	ki-67	PUNCT
dpc-5172	206	2	is	be	AUX
dpc-5172	206	3	a	a	DET
dpc-5172	206	4	nuclear	nuclear	ADJ
dpc-5172	206	5	protein	protein	NOUN
dpc-5172	206	6	expressed	express	VERB
dpc-5172	206	7	during	during	ADP
dpc-5172	206	8	active	active	ADJ
dpc-5172	206	9	phases	phase	NOUN
dpc-5172	206	10	of	of	ADP
dpc-5172	206	11	the	the	DET
dpc-5172	206	12	cell	cell	NOUN
dpc-5172	206	13	cycle	cycle	NOUN
dpc-5172	206	14	,	,	PUNCT
dpc-5172	206	15	making	make	VERB
dpc-5172	206	16	it	it	PRON
dpc-5172	206	17	a	a	DET
dpc-5172	206	18	widely	widely	ADV
dpc-5172	206	19	used	use	VERB
dpc-5172	206	20	marker	marker	NOUN
dpc-5172	206	21	of	of	ADP
dpc-5172	206	22	cellular	cellular	ADJ
dpc-5172	206	23	proliferation	proliferation	NOUN
dpc-5172	206	24	[	[	X
dpc-5172	206	25	23	23	NUM
dpc-5172	206	26	]	]	PUNCT
dpc-5172	206	27	.	.	PUNCT
dpc-5172	207	1	increased	increase	VERB
dpc-5172	207	2	ki-67	ki-67	ADJ
dpc-5172	207	3	expression	expression	NOUN
dpc-5172	207	4	following	follow	VERB
dpc-5172	207	5	tretinoin	tretinoin	PROPN
dpc-5172	207	6	treatment	treatment	NOUN
dpc-5172	207	7	indicates	indicate	VERB
dpc-5172	207	8	increased	increase	VERB
dpc-5172	207	9	keratinocyte	keratinocyte	NOUN
dpc-5172	207	10	turnover	turnover	NOUN
dpc-5172	207	11	,	,	PUNCT
dpc-5172	207	12	which	which	PRON
dpc-5172	207	13	often	often	ADV
dpc-5172	207	14	correlates	correlate	VERB
dpc-5172	207	15	with	with	ADP
dpc-5172	207	16	visible	visible	ADJ
dpc-5172	207	17	improvements	improvement	NOUN
dpc-5172	207	18	in	in	ADP
dpc-5172	207	19	skin	skin	NOUN
dpc-5172	207	20	appearance	appearance	NOUN
dpc-5172	208	1	[	[	X
dpc-5172	208	2	23	23	NUM
dpc-5172	208	3	]	]	PUNCT
dpc-5172	208	4	.	.	PUNCT
dpc-5172	209	1	additionally	additionally	ADV
dpc-5172	209	2	,	,	PUNCT
dpc-5172	209	3	tretinoin	tretinoin	PROPN
dpc-5172	209	4	upregulates	upregulate	VERB
dpc-5172	209	5	egfr	egfr	ADJ
dpc-5172	209	6	ligands	ligand	NOUN
dpc-5172	209	7	such	such	ADJ
dpc-5172	209	8	as	as	ADP
dpc-5172	209	9	amphiregulin	amphiregulin	PROPN
dpc-5172	209	10	(	(	PUNCT
dpc-5172	209	11	ar	ar	NOUN
dpc-5172	209	12	)	)	PUNCT
dpc-5172	209	13	and	and	CCONJ
dpc-5172	209	14	heparin	heparin	NOUN
dpc-5172	209	15	-	-	PUNCT
dpc-5172	209	16	binding	bind	VERB
dpc-5172	209	17	epidermal	epidermal	ADJ
dpc-5172	209	18	growth	growth	NOUN
dpc-5172	209	19	factor	factor	NOUN
dpc-5172	209	20	–	–	PUNCT
dpc-5172	209	21	like	like	ADJ
dpc-5172	209	22	growth	growth	NOUN
dpc-5172	209	23	factor	factor	NOUN
dpc-5172	209	24	(	(	PUNCT
dpc-5172	209	25	hb	hb	PROPN
dpc-5172	209	26	-	-	PUNCT
dpc-5172	209	27	egf	egf	PROPN
dpc-5172	209	28	)	)	PUNCT
dpc-5172	209	29	,	,	PUNCT
dpc-5172	209	30	which	which	PRON
dpc-5172	209	31	further	far	ADV
dpc-5172	209	32	promote	promote	VERB
dpc-5172	209	33	keratinocyte	keratinocyte	NOUN
dpc-5172	209	34	activity	activity	NOUN
dpc-5172	209	35	and	and	CCONJ
dpc-5172	209	36	epidermal	epidermal	ADJ
dpc-5172	209	37	hyperplasia	hyperplasia	NOUN
dpc-5172	209	38	[	[	X
dpc-5172	209	39	24	24	NUM
dpc-5172	209	40	]	]	PUNCT
dpc-5172	209	41	.	.	PUNCT
dpc-5172	210	1	these	these	DET
dpc-5172	210	2	molecular	molecular	ADJ
dpc-5172	210	3	effects	effect	NOUN
dpc-5172	210	4	support	support	VERB
dpc-5172	210	5	tretinoin	tretinoin	PROPN
dpc-5172	210	6	’s	’s	PART
dpc-5172	210	7	role	role	NOUN
dpc-5172	210	8	in	in	ADP
dpc-5172	210	9	reversing	reverse	VERB
dpc-5172	210	10	photodamage	photodamage	NOUN
dpc-5172	210	11	and	and	CCONJ
dpc-5172	210	12	may	may	AUX
dpc-5172	210	13	guide	guide	VERB
dpc-5172	210	14	personalized	personalized	ADJ
dpc-5172	210	15	treatment	treatment	NOUN
dpc-5172	210	16	strategies	strategy	NOUN
dpc-5172	210	17	.	.	PUNCT
dpc-5172	211	1	in	in	ADP
dpc-5172	211	2	the	the	DET
dpc-5172	211	3	current	current	ADJ
dpc-5172	211	4	analysis	analysis	NOUN
dpc-5172	211	5	,	,	PUNCT
dpc-5172	211	6	in	in	ADP
dpc-5172	211	7	addition	addition	NOUN
dpc-5172	211	8	to	to	ADP
dpc-5172	211	9	the	the	DET
dpc-5172	211	10	significant	significant	ADJ
dpc-5172	211	11	improvements	improvement	NOUN
dpc-5172	211	12	in	in	ADP
dpc-5172	211	13	facial	facial	ADJ
dpc-5172	211	14	wrinkles	wrinkle	NOUN
dpc-5172	211	15	noted	note	VERB
dpc-5172	211	16	by	by	ADP
dpc-5172	211	17	professional	professional	ADJ
dpc-5172	211	18	investigators	investigator	NOUN
dpc-5172	211	19	,	,	PUNCT
dpc-5172	211	20	the	the	DET
dpc-5172	211	21	study	study	NOUN
dpc-5172	211	22	participants	participant	NOUN
dpc-5172	211	23	reported	report	VERB
dpc-5172	211	24	noticeable	noticeable	ADJ
dpc-5172	211	25	enhancements	enhancement	NOUN
dpc-5172	211	26	in	in	ADP
dpc-5172	211	27	the	the	DET
dpc-5172	211	28	overall	overall	ADJ
dpc-5172	211	29	appearance	appearance	NOUN
dpc-5172	211	30	and	and	CCONJ
dpc-5172	211	31	texture	texture	NOUN
dpc-5172	211	32	of	of	ADP
dpc-5172	211	33	their	their	PRON
dpc-5172	211	34	photodamaged	photodamage	VERB
dpc-5172	211	35	skin	skin	NOUN
dpc-5172	211	36	following	follow	VERB
dpc-5172	211	37	treatment	treatment	NOUN
dpc-5172	211	38	(	(	PUNCT
dpc-5172	211	39	p=0.026	p=0.026	NOUN
dpc-5172	211	40	)	)	PUNCT
dpc-5172	211	41	.	.	PUNCT
dpc-5172	212	1	the	the	DET
dpc-5172	212	2	sensitivity	sensitivity	NOUN
dpc-5172	212	3	analysis	analysis	NOUN
dpc-5172	212	4	conducted	conduct	VERB
dpc-5172	212	5	using	use	VERB
dpc-5172	212	6	the	the	DET
dpc-5172	212	7	one	one	NUM
dpc-5172	212	8	-	-	PUNCT
dpc-5172	212	9	study	study	NOUN
dpc-5172	212	10	-	-	PUNCT
dpc-5172	212	11	removal	removal	NOUN
dpc-5172	212	12	method	method	NOUN
dpc-5172	212	13	confirmed	confirm	VERB
dpc-5172	212	14	the	the	DET
dpc-5172	212	15	robustness	robustness	NOUN
dpc-5172	212	16	of	of	ADP
dpc-5172	212	17	these	these	DET
dpc-5172	212	18	findings	finding	NOUN
dpc-5172	212	19	.	.	PUNCT
dpc-5172	213	1	the	the	DET
dpc-5172	213	2	significant	significant	ADJ
dpc-5172	213	3	improvement	improvement	NOUN
dpc-5172	213	4	in	in	ADP
dpc-5172	213	5	the	the	DET
dpc-5172	213	6	patient	patient	NOUN
dpc-5172	213	7	self	self	NOUN
dpc-5172	213	8	-	-	PUNCT
dpc-5172	213	9	assessments	assessment	NOUN
dpc-5172	213	10	further	far	ADV
dpc-5172	213	11	confirms	confirm	VERB
dpc-5172	213	12	the	the	DET
dpc-5172	213	13	therapeutic	therapeutic	ADJ
dpc-5172	213	14	effect	effect	NOUN
dpc-5172	213	15	of	of	ADP
dpc-5172	213	16	tretinoin	tretinoin	NOUN
dpc-5172	213	17	on	on	ADP
dpc-5172	213	18	both	both	CCONJ
dpc-5172	213	19	objective	objective	ADJ
dpc-5172	213	20	and	and	CCONJ
dpc-5172	213	21	subjective	subjective	ADJ
dpc-5172	213	22	measures	measure	NOUN
dpc-5172	213	23	.	.	PUNCT
dpc-5172	214	1	the	the	DET
dpc-5172	214	2	results	result	NOUN
dpc-5172	214	3	confirm	confirm	VERB
dpc-5172	214	4	that	that	SCONJ
dpc-5172	214	5	tretinoin	tretinoin	PROPN
dpc-5172	214	6	significantly	significantly	ADV
dpc-5172	214	7	improves	improve	VERB
dpc-5172	214	8	fine	fine	ADJ
dpc-5172	214	9	and	and	CCONJ
dpc-5172	214	10	coarse	coarse	ADJ
dpc-5172	214	11	wrinkles	wrinkle	NOUN
dpc-5172	214	12	;	;	PUNCT
dpc-5172	214	13	however	however	ADV
dpc-5172	214	14	,	,	PUNCT
dpc-5172	214	15	its	its	PRON
dpc-5172	214	16	impact	impact	NOUN
dpc-5172	214	17	on	on	ADP
dpc-5172	214	18	quality	quality	NOUN
dpc-5172	214	19	of	of	ADP
dpc-5172	214	20	life	life	NOUN
dpc-5172	214	21	is	be	AUX
dpc-5172	214	22	also	also	ADV
dpc-5172	214	23	a	a	DET
dpc-5172	214	24	critical	critical	ADJ
dpc-5172	214	25	concern	concern	NOUN
dpc-5172	214	26	.	.	PUNCT
dpc-5172	215	1	the	the	DET
dpc-5172	215	2	patient	patient	NOUN
dpc-5172	215	3	-	-	PUNCT
dpc-5172	215	4	reported	report	VERB
dpc-5172	215	5	outcomes	outcome	NOUN
dpc-5172	215	6	in	in	ADP
dpc-5172	215	7	this	this	DET
dpc-5172	215	8	study	study	NOUN
dpc-5172	215	9	indicated	indicate	VERB
dpc-5172	215	10	improvements	improvement	NOUN
dpc-5172	215	11	in	in	ADP
dpc-5172	215	12	skin	skin	NOUN
dpc-5172	215	13	appearance	appearance	NOUN
dpc-5172	215	14	and	and	CCONJ
dpc-5172	215	15	texture	texture	NOUN
dpc-5172	215	16	,	,	PUNCT
dpc-5172	215	17	suggesting	suggest	VERB
dpc-5172	215	18	potential	potential	ADJ
dpc-5172	215	19	psychological	psychological	ADJ
dpc-5172	215	20	and	and	CCONJ
dpc-5172	215	21	emotional	emotional	ADJ
dpc-5172	215	22	benefits	benefit	NOUN
dpc-5172	215	23	associated	associate	VERB
dpc-5172	215	24	with	with	ADP
dpc-5172	215	25	treatment	treatment	NOUN
dpc-5172	215	26	.	.	PUNCT
dpc-5172	216	1	although	although	SCONJ
dpc-5172	216	2	tretinoin	tretinoin	PROPN
dpc-5172	216	3	demonstrated	demonstrate	VERB
dpc-5172	216	4	significant	significant	ADJ
dpc-5172	216	5	efficacy	efficacy	NOUN
dpc-5172	216	6	in	in	ADP
dpc-5172	216	7	improving	improve	VERB
dpc-5172	216	8	photodamaged	photodamage	VERB
dpc-5172	216	9	skin	skin	NOUN
dpc-5172	216	10	(	(	PUNCT
dpc-5172	216	11	p<0.001	p<0.001	PROPN
dpc-5172	216	12	)	)	PUNCT
dpc-5172	216	13	,	,	PUNCT
dpc-5172	216	14	patients	patient	NOUN
dpc-5172	216	15	were	be	AUX
dpc-5172	216	16	frequently	frequently	ADV
dpc-5172	216	17	affected	affect	VERB
dpc-5172	216	18	by	by	ADP
dpc-5172	216	19	adverse	adverse	ADJ
dpc-5172	216	20	reactions	reaction	NOUN
dpc-5172	216	21	.	.	PUNCT
dpc-5172	217	1	across	across	ADP
dpc-5172	217	2	the	the	DET
dpc-5172	217	3	included	include	VERB
dpc-5172	217	4	trials	trial	NOUN
dpc-5172	217	5	,	,	PUNCT
dpc-5172	217	6	individuals	individual	NOUN
dpc-5172	217	7	receiving	receive	VERB
dpc-5172	217	8	tretinoin	tretinoin	NOUN
dpc-5172	217	9	experienced	experience	VERB
dpc-5172	217	10	various	various	ADJ
dpc-5172	217	11	forms	form	NOUN
dpc-5172	217	12	of	of	ADP
dpc-5172	217	13	cutaneous	cutaneous	ADJ
dpc-5172	217	14	irritation	irritation	NOUN
dpc-5172	217	15	,	,	PUNCT
dpc-5172	217	16	such	such	ADJ
dpc-5172	217	17	as	as	ADP
dpc-5172	217	18	dryness	dryness	NOUN
dpc-5172	217	19	,	,	PUNCT
dpc-5172	217	20	erythema	erythema	ADV
dpc-5172	217	21	,	,	PUNCT
dpc-5172	217	22	peeling	peel	VERB
dpc-5172	217	23	,	,	PUNCT
dpc-5172	217	24	burning	burning	NOUN
dpc-5172	217	25	,	,	PUNCT
dpc-5172	217	26	and	and	CCONJ
dpc-5172	217	27	stinging	sting	VERB
dpc-5172	217	28	,	,	PUNCT
dpc-5172	217	29	particularly	particularly	ADV
dpc-5172	217	30	during	during	ADP
dpc-5172	217	31	the	the	DET
dpc-5172	217	32	initial	initial	ADJ
dpc-5172	217	33	weeks	week	NOUN
dpc-5172	217	34	of	of	ADP
dpc-5172	217	35	treatment	treatment	NOUN
dpc-5172	217	36	[	[	X
dpc-5172	217	37	1,2,4	1,2,4	NUM
dpc-5172	217	38	-	-	SYM
dpc-5172	217	39	8,19	8,19	NUM
dpc-5172	217	40	]	]	PUNCT
dpc-5172	217	41	.	.	PUNCT
dpc-5172	218	1	the	the	DET
dpc-5172	218	2	severity	severity	NOUN
dpc-5172	218	3	of	of	ADP
dpc-5172	218	4	these	these	DET
dpc-5172	218	5	effects	effect	NOUN
dpc-5172	218	6	was	be	AUX
dpc-5172	218	7	generally	generally	ADV
dpc-5172	218	8	mild	mild	ADJ
dpc-5172	219	1	[	[	X
dpc-5172	219	2	2,4,7,8,19	2,4,7,8,19	NUM
dpc-5172	219	3	]	]	PUNCT
dpc-5172	219	4	or	or	CCONJ
dpc-5172	219	5	mild	mild	ADJ
dpc-5172	219	6	-	-	PUNCT
dpc-5172	219	7	to	to	ADP
dpc-5172	219	8	-	-	PUNCT
dpc-5172	219	9	moderate	moderate	ADJ
dpc-5172	220	1	[	[	X
dpc-5172	220	2	5,6	5,6	NUM
dpc-5172	220	3	]	]	PUNCT
dpc-5172	220	4	.	.	PUNCT
dpc-5172	221	1	it	it	PRON
dpc-5172	221	2	is	be	AUX
dpc-5172	221	3	worth	worth	ADJ
dpc-5172	221	4	noting	note	VERB
dpc-5172	221	5	that	that	SCONJ
dpc-5172	221	6	considerable	considerable	ADJ
dpc-5172	221	7	heterogeneity	heterogeneity	NOUN
dpc-5172	221	8	was	be	AUX
dpc-5172	221	9	observed	observe	VERB
dpc-5172	221	10	in	in	ADP
dpc-5172	221	11	the	the	DET
dpc-5172	221	12	tertiary	tertiary	ADJ
dpc-5172	221	13	outcome	outcome	NOUN
dpc-5172	221	14	related	relate	VERB
dpc-5172	221	15	to	to	ADP
dpc-5172	221	16	adverse	adverse	ADJ
dpc-5172	221	17	events	event	NOUN
dpc-5172	221	18	.	.	PUNCT
dpc-5172	222	1	this	this	DET
dpc-5172	222	2	variability	variability	NOUN
dpc-5172	222	3	is	be	AUX
dpc-5172	222	4	likely	likely	ADV
dpc-5172	222	5	attributable	attributable	ADJ
dpc-5172	222	6	to	to	ADP
dpc-5172	222	7	differences	difference	NOUN
dpc-5172	222	8	in	in	ADP
dpc-5172	222	9	study	study	NOUN
dpc-5172	222	10	duration	duration	NOUN
dpc-5172	222	11	,	,	PUNCT
dpc-5172	222	12	tretinoin	tretinoin	PROPN
dpc-5172	222	13	concentrations	concentration	NOUN
dpc-5172	222	14	,	,	PUNCT
dpc-5172	222	15	vehicle	vehicle	NOUN
dpc-5172	222	16	formulations	formulation	NOUN
dpc-5172	222	17	,	,	PUNCT
dpc-5172	222	18	and	and	CCONJ
dpc-5172	222	19	the	the	DET
dpc-5172	222	20	subjective	subjective	ADJ
dpc-5172	222	21	nature	nature	NOUN
dpc-5172	222	22	of	of	ADP
dpc-5172	222	23	reporting	report	VERB
dpc-5172	222	24	symptoms	symptom	NOUN
dpc-5172	222	25	such	such	ADJ
dpc-5172	222	26	as	as	ADP
dpc-5172	222	27	irritation	irritation	NOUN
dpc-5172	222	28	or	or	CCONJ
dpc-5172	222	29	dryness	dryness	NOUN
dpc-5172	222	30	,	,	PUNCT
dpc-5172	222	31	which	which	PRON
dpc-5172	222	32	are	be	AUX
dpc-5172	222	33	heavily	heavily	ADV
dpc-5172	222	34	influenced	influence	VERB
dpc-5172	222	35	by	by	ADP
dpc-5172	222	36	individual	individual	ADJ
dpc-5172	222	37	tolerance	tolerance	NOUN
dpc-5172	222	38	and	and	CCONJ
dpc-5172	222	39	study	study	NOUN
dpc-5172	222	40	-	-	PUNCT
dpc-5172	222	41	specific	specific	ADJ
dpc-5172	222	42	factors	factor	NOUN
dpc-5172	222	43	.	.	PUNCT
dpc-5172	223	1	in	in	ADP
dpc-5172	223	2	some	some	DET
dpc-5172	223	3	cases	case	NOUN
dpc-5172	223	4	,	,	PUNCT
dpc-5172	223	5	these	these	DET
dpc-5172	223	6	adverse	adverse	ADJ
dpc-5172	223	7	(	(	PUNCT
dpc-5172	223	8	or	or	CCONJ
dpc-5172	223	9	:	:	PUNCT
dpc-5172	223	10	3.140	3.140	NUM
dpc-5172	223	11	;	;	PUNCT
dpc-5172	223	12	95	95	NUM
dpc-5172	223	13	%	%	NOUN
dpc-5172	223	14	ci	ci	NOUN
dpc-5172	223	15	:	:	PUNCT
dpc-5172	223	16	1.819–5.419	1.819–5.419	NUM
dpc-5172	223	17	;	;	PUNCT
dpc-5172	223	18	p<0.001	p<0.001	X
dpc-5172	223	19	;	;	PUNCT
dpc-5172	223	20	i²=73.261	i²=73.261	ADJ
dpc-5172	223	21	%	%	NOUN
dpc-5172	223	22	;	;	PUNCT
dpc-5172	223	23	figure	figure	NOUN
dpc-5172	223	24	s8	s8	NOUN
dpc-5172	223	25	)	)	PUNCT
dpc-5172	223	26	.	.	PUNCT
dpc-5172	224	1	discussion	discussion	NOUN
dpc-5172	224	2	this	this	DET
dpc-5172	224	3	systematic	systematic	ADJ
dpc-5172	224	4	review	review	NOUN
dpc-5172	224	5	and	and	CCONJ
dpc-5172	224	6	meta	meta	NOUN
dpc-5172	224	7	-	-	PUNCT
dpc-5172	224	8	analysis	analysis	NOUN
dpc-5172	224	9	is	be	AUX
dpc-5172	224	10	the	the	DET
dpc-5172	224	11	first	first	ADJ
dpc-5172	224	12	to	to	PART
dpc-5172	224	13	comprehensively	comprehensively	ADV
dpc-5172	224	14	evaluate	evaluate	VERB
dpc-5172	224	15	both	both	DET
dpc-5172	224	16	the	the	DET
dpc-5172	224	17	safety	safety	NOUN
dpc-5172	224	18	and	and	CCONJ
dpc-5172	224	19	the	the	DET
dpc-5172	224	20	efficacy	efficacy	NOUN
dpc-5172	224	21	of	of	ADP
dpc-5172	224	22	tretinoin	tretinoin	PROPN
dpc-5172	224	23	in	in	ADP
dpc-5172	224	24	treating	treat	VERB
dpc-5172	224	25	photodamage	photodamage	NOUN
dpc-5172	224	26	-	-	PUNCT
dpc-5172	224	27	induced	induce	VERB
dpc-5172	224	28	facial	facial	ADJ
dpc-5172	224	29	wrinkles	wrinkle	NOUN
dpc-5172	224	30	.	.	PUNCT
dpc-5172	225	1	the	the	DET
dpc-5172	225	2	results	result	NOUN
dpc-5172	225	3	revealed	reveal	VERB
dpc-5172	225	4	significant	significant	ADJ
dpc-5172	225	5	improvements	improvement	NOUN
dpc-5172	225	6	in	in	ADP
dpc-5172	225	7	both	both	CCONJ
dpc-5172	225	8	fine	fine	ADJ
dpc-5172	225	9	and	and	CCONJ
dpc-5172	225	10	coarse	coarse	ADJ
dpc-5172	225	11	facial	facial	ADJ
dpc-5172	225	12	wrinkles	wrinkle	NOUN
dpc-5172	225	13	following	follow	VERB
dpc-5172	225	14	tretinoin	tretinoin	NOUN
dpc-5172	225	15	treatment	treatment	NOUN
dpc-5172	225	16	compared	compare	VERB
dpc-5172	225	17	with	with	ADP
dpc-5172	225	18	after	after	ADP
dpc-5172	225	19	the	the	DET
dpc-5172	225	20	use	use	NOUN
dpc-5172	225	21	of	of	ADP
dpc-5172	225	22	a	a	DET
dpc-5172	225	23	vehicle	vehicle	NOUN
dpc-5172	225	24	.	.	PUNCT
dpc-5172	226	1	these	these	DET
dpc-5172	226	2	findings	finding	NOUN
dpc-5172	226	3	remained	remain	VERB
dpc-5172	226	4	robust	robust	ADJ
dpc-5172	226	5	in	in	ADP
dpc-5172	226	6	sensitivity	sensitivity	NOUN
dpc-5172	226	7	analyses	analysis	NOUN
dpc-5172	226	8	conducted	conduct	VERB
dpc-5172	226	9	using	use	VERB
dpc-5172	226	10	the	the	DET
dpc-5172	226	11	one	one	NUM
dpc-5172	226	12	-	-	PUNCT
dpc-5172	226	13	study	study	NOUN
dpc-5172	226	14	-	-	PUNCT
dpc-5172	226	15	removal	removal	NOUN
dpc-5172	226	16	method	method	NOUN
dpc-5172	226	17	.	.	PUNCT
dpc-5172	227	1	in	in	ADP
dpc-5172	227	2	our	our	PRON
dpc-5172	227	3	meta	meta	ADJ
dpc-5172	227	4	-	-	PUNCT
dpc-5172	227	5	analysis	analysis	NOUN
dpc-5172	227	6	,	,	PUNCT
dpc-5172	227	7	no	no	DET
dpc-5172	227	8	significant	significant	ADJ
dpc-5172	227	9	heterogeneity	heterogeneity	NOUN
dpc-5172	227	10	was	be	AUX
dpc-5172	227	11	noted	note	VERB
dpc-5172	227	12	among	among	ADP
dpc-5172	227	13	studies	study	NOUN
dpc-5172	227	14	assessing	assess	VERB
dpc-5172	227	15	the	the	DET
dpc-5172	227	16	efficacy	efficacy	NOUN
dpc-5172	227	17	of	of	ADP
dpc-5172	227	18	tretinoin	tretinoin	PROPN
dpc-5172	227	19	for	for	ADP
dpc-5172	227	20	coarse	coarse	ADJ
dpc-5172	227	21	wrinkles	wrinkle	NOUN
dpc-5172	227	22	,	,	PUNCT
dpc-5172	227	23	and	and	CCONJ
dpc-5172	227	24	only	only	ADV
dpc-5172	227	25	moderate	moderate	ADJ
dpc-5172	227	26	heterogeneity	heterogeneity	NOUN
dpc-5172	227	27	was	be	AUX
dpc-5172	227	28	observed	observe	VERB
dpc-5172	227	29	in	in	ADP
dpc-5172	227	30	those	those	PRON
dpc-5172	227	31	evaluating	evaluate	VERB
dpc-5172	227	32	fine	fine	ADJ
dpc-5172	227	33	wrinkles	wrinkle	NOUN
dpc-5172	227	34	,	,	PUNCT
dpc-5172	227	35	suggesting	suggest	VERB
dpc-5172	227	36	consistent	consistent	ADJ
dpc-5172	227	37	therapeutic	therapeutic	ADJ
dpc-5172	227	38	benefits	benefit	NOUN
dpc-5172	227	39	across	across	ADP
dpc-5172	227	40	different	different	ADJ
dpc-5172	227	41	patient	patient	ADJ
dpc-5172	227	42	populations	population	NOUN
dpc-5172	227	43	and	and	CCONJ
dpc-5172	227	44	study	study	NOUN
dpc-5172	227	45	designs	design	NOUN
dpc-5172	227	46	.	.	PUNCT
dpc-5172	228	1	this	this	DET
dpc-5172	228	2	homogeneity	homogeneity	NOUN
dpc-5172	228	3	may	may	AUX
dpc-5172	228	4	be	be	AUX
dpc-5172	228	5	attributed	attribute	VERB
dpc-5172	228	6	to	to	ADP
dpc-5172	228	7	the	the	DET
dpc-5172	228	8	relatively	relatively	ADV
dpc-5172	228	9	standardized	standardized	ADJ
dpc-5172	228	10	treatment	treatment	NOUN
dpc-5172	228	11	protocols	protocol	NOUN
dpc-5172	228	12	and	and	CCONJ
dpc-5172	228	13	objective	objective	ADJ
dpc-5172	228	14	efficacy	efficacy	NOUN
dpc-5172	228	15	measurements	measurement	NOUN
dpc-5172	228	16	,	,	PUNCT
dpc-5172	228	17	such	such	ADJ
dpc-5172	228	18	as	as	ADP
dpc-5172	228	19	global	global	ADJ
dpc-5172	228	20	photographic	photographic	ADJ
dpc-5172	228	21	assessment	assessment	NOUN
dpc-5172	228	22	and	and	CCONJ
dpc-5172	228	23	lesion	lesion	NOUN
dpc-5172	228	24	count	count	NOUN
dpc-5172	228	25	reduction	reduction	NOUN
dpc-5172	228	26	.	.	PUNCT
dpc-5172	229	1	photoaging	photoage	VERB
dpc-5172	229	2	is	be	AUX
dpc-5172	229	3	an	an	DET
dpc-5172	229	4	extrinsic	extrinsic	ADJ
dpc-5172	229	5	factor	factor	NOUN
dpc-5172	229	6	that	that	PRON
dpc-5172	229	7	contributes	contribute	VERB
dpc-5172	229	8	to	to	ADP
dpc-5172	229	9	the	the	DET
dpc-5172	229	10	development	development	NOUN
dpc-5172	229	11	of	of	ADP
dpc-5172	229	12	wrinkles	wrinkle	NOUN
dpc-5172	229	13	.	.	PUNCT
dpc-5172	230	1	ultraviolet	ultraviolet	ADJ
dpc-5172	230	2	light	light	ADJ
dpc-5172	230	3	exposure	exposure	NOUN
dpc-5172	230	4	leads	lead	VERB
dpc-5172	230	5	to	to	ADP
dpc-5172	230	6	histologic	histologic	ADJ
dpc-5172	230	7	damage	damage	NOUN
dpc-5172	230	8	to	to	ADP
dpc-5172	230	9	the	the	DET
dpc-5172	230	10	skin	skin	NOUN
dpc-5172	230	11	,	,	PUNCT
dpc-5172	230	12	including	include	VERB
dpc-5172	230	13	epidermal	epidermal	ADJ
dpc-5172	230	14	dysplasia	dysplasia	NOUN
dpc-5172	230	15	and	and	CCONJ
dpc-5172	230	16	atrophy	atrophy	NOUN
dpc-5172	230	17	,	,	PUNCT
dpc-5172	230	18	substantial	substantial	ADJ
dpc-5172	230	19	elastosis	elastosis	NOUN
dpc-5172	230	20	in	in	ADP
dpc-5172	230	21	the	the	DET
dpc-5172	230	22	dermis	dermis	NOUN
dpc-5172	230	23	,	,	PUNCT
dpc-5172	230	24	increased	increase	VERB
dpc-5172	230	25	melanocyte	melanocyte	NOUN
dpc-5172	230	26	activity	activity	NOUN
dpc-5172	230	27	,	,	PUNCT
dpc-5172	230	28	and	and	CCONJ
dpc-5172	230	29	high	high	ADJ
dpc-5172	230	30	levels	level	NOUN
dpc-5172	230	31	of	of	ADP
dpc-5172	230	32	glycosaminoglycans	glycosaminoglycan	NOUN
dpc-5172	230	33	and	and	CCONJ
dpc-5172	230	34	inflammatory	inflammatory	ADJ
dpc-5172	230	35	infiltrates	infiltrate	NOUN
dpc-5172	230	36	[	[	X
dpc-5172	230	37	1,4	1,4	NUM
dpc-5172	230	38	]	]	X
dpc-5172	230	39	.	.	PUNCT
dpc-5172	231	1	additionally	additionally	ADV
dpc-5172	231	2	,	,	PUNCT
dpc-5172	231	3	the	the	DET
dpc-5172	231	4	degradation	degradation	NOUN
dpc-5172	231	5	of	of	ADP
dpc-5172	231	6	collagen	collagen	NOUN
dpc-5172	231	7	and	and	CCONJ
dpc-5172	231	8	accumulation	accumulation	NOUN
dpc-5172	231	9	of	of	ADP
dpc-5172	231	10	elastotic	elastotic	ADJ
dpc-5172	231	11	material	material	NOUN
dpc-5172	231	12	in	in	ADP
dpc-5172	231	13	the	the	DET
dpc-5172	231	14	dermal	dermal	ADJ
dpc-5172	231	15	extracellular	extracellular	ADJ
dpc-5172	231	16	matrix	matrix	NOUN
dpc-5172	231	17	reduce	reduce	VERB
dpc-5172	231	18	mechanical	mechanical	ADJ
dpc-5172	231	19	support	support	NOUN
dpc-5172	231	20	to	to	ADP
dpc-5172	231	21	the	the	DET
dpc-5172	231	22	epidermis	epidermis	NOUN
dpc-5172	232	1	[	[	X
dpc-5172	232	2	4	4	NUM
dpc-5172	232	3	]	]	PUNCT
dpc-5172	232	4	,	,	PUNCT
dpc-5172	232	5	ultimately	ultimately	ADV
dpc-5172	232	6	contributing	contribute	VERB
dpc-5172	232	7	to	to	ADP
dpc-5172	232	8	photodamage	photodamage	NOUN
dpc-5172	232	9	-	-	PUNCT
dpc-5172	232	10	induced	induce	VERB
dpc-5172	232	11	facial	facial	ADJ
dpc-5172	232	12	wrinkling	wrinkling	NOUN
dpc-5172	233	1	[	[	X
dpc-5172	233	2	7	7	NUM
dpc-5172	233	3	]	]	PUNCT
dpc-5172	233	4	.	.	PUNCT
dpc-5172	234	1	five	five	NUM
dpc-5172	234	2	of	of	ADP
dpc-5172	234	3	the	the	DET
dpc-5172	234	4	eight	eight	NUM
dpc-5172	234	5	trials	trial	NOUN
dpc-5172	234	6	included	include	VERB
dpc-5172	234	7	in	in	ADP
dpc-5172	234	8	this	this	DET
dpc-5172	234	9	review	review	NOUN
dpc-5172	234	10	assessed	assess	VERB
dpc-5172	234	11	histological	histological	ADJ
dpc-5172	234	12	changes	change	NOUN
dpc-5172	234	13	in	in	ADP
dpc-5172	234	14	skin	skin	NOUN
dpc-5172	234	15	biopsies	biopsy	NOUN
dpc-5172	234	16	before	before	ADV
dpc-5172	234	17	and	and	CCONJ
dpc-5172	234	18	after	after	ADP
dpc-5172	234	19	tretinoin	tretinoin	PROPN
dpc-5172	234	20	treatment	treatment	NOUN
dpc-5172	234	21	[	[	X
dpc-5172	234	22	1,4,5,7,19	1,4,5,7,19	PROPN
dpc-5172	234	23	]	]	PUNCT
dpc-5172	234	24	.	.	PUNCT
dpc-5172	235	1	across	across	ADP
dpc-5172	235	2	these	these	DET
dpc-5172	235	3	studies	study	NOUN
dpc-5172	235	4	,	,	PUNCT
dpc-5172	235	5	tretinoin	tretinoin	PROPN
dpc-5172	235	6	consistently	consistently	ADV
dpc-5172	235	7	induced	induce	VERB
dpc-5172	235	8	epidermal	epidermal	ADJ
dpc-5172	235	9	thickening	thickening	NOUN
dpc-5172	235	10	,	,	PUNCT
dpc-5172	235	11	compaction	compaction	NOUN
dpc-5172	235	12	of	of	ADP
dpc-5172	235	13	the	the	DET
dpc-5172	235	14	stratum	stratum	NOUN
dpc-5172	235	15	corneum	corneum	NOUN
dpc-5172	235	16	,	,	PUNCT
dpc-5172	235	17	granular	granular	ADJ
dpc-5172	235	18	layer	layer	NOUN
dpc-5172	235	19	expansion	expansion	NOUN
dpc-5172	235	20	,	,	PUNCT
dpc-5172	235	21	and	and	CCONJ
dpc-5172	235	22	reduced	reduce	VERB
dpc-5172	235	23	melanin	melanin	NOUN
dpc-5172	235	24	content	content	NOUN
dpc-5172	235	25	,	,	PUNCT
dpc-5172	235	26	changes	change	NOUN
dpc-5172	235	27	associated	associate	VERB
dpc-5172	235	28	with	with	ADP
dpc-5172	235	29	improved	improved	ADJ
dpc-5172	235	30	skin	skin	NOUN
dpc-5172	235	31	texture	texture	NOUN
dpc-5172	235	32	and	and	CCONJ
dpc-5172	235	33	reduced	reduce	VERB
dpc-5172	235	34	wrinkle	wrinkle	NOUN
dpc-5172	235	35	appearance	appearance	NOUN
dpc-5172	235	36	[	[	X
dpc-5172	235	37	1,5,7,19	1,5,7,19	NUM
dpc-5172	235	38	]	]	X
dpc-5172	235	39	.	.	PUNCT
dpc-5172	236	1	one	one	NUM
dpc-5172	236	2	study	study	NOUN
dpc-5172	236	3	also	also	ADV
dpc-5172	236	4	reported	report	VERB
dpc-5172	236	5	increased	increased	ADJ
dpc-5172	236	6	levels	level	NOUN
dpc-5172	236	7	of	of	ADP
dpc-5172	236	8	procollagen	procollagen	NOUN
dpc-5172	236	9	1	1	NUM
dpc-5172	236	10	c	c	NOUN
dpc-5172	236	11	-	-	PUNCT
dpc-5172	236	12	terminal	terminal	ADJ
dpc-5172	236	13	(	(	PUNCT
dpc-5172	236	14	pic	pic	NOUN
dpc-5172	236	15	)	)	PUNCT
dpc-5172	236	16	and	and	CCONJ
dpc-5172	236	17	n	n	CCONJ
dpc-5172	236	18	-	-	PUNCT
dpc-5172	236	19	terminal	terminal	ADJ
dpc-5172	236	20	(	(	PUNCT
dpc-5172	236	21	sp1	sp1	NOUN
dpc-5172	236	22	)	)	PUNCT
dpc-5172	236	23	levels	level	NOUN
dpc-5172	236	24	,	,	PUNCT
dpc-5172	236	25	suggesting	suggest	VERB
dpc-5172	236	26	enhanced	enhanced	ADJ
dpc-5172	236	27	collagen	collagen	NOUN
dpc-5172	236	28	synthesis	synthesis	NOUN
dpc-5172	236	29	as	as	ADP
dpc-5172	236	30	a	a	DET
dpc-5172	236	31	mechanism	mechanism	NOUN
dpc-5172	236	32	for	for	ADP
dpc-5172	236	33	wrinkle	wrinkle	NOUN
dpc-5172	236	34	reduction	reduction	NOUN
dpc-5172	236	35	[	[	X
dpc-5172	236	36	4	4	NUM
dpc-5172	236	37	]	]	PUNCT
dpc-5172	236	38	.	.	PUNCT
dpc-5172	237	1	the	the	DET
dpc-5172	237	2	epidermal	epidermal	ADJ
dpc-5172	237	3	response	response	NOUN
dpc-5172	237	4	observed	observed	ADJ
dpc-5172	237	5	following	follow	VERB
dpc-5172	237	6	topical	topical	ADJ
dpc-5172	237	7	tretinoin	tretinoin	NOUN
dpc-5172	237	8	application	application	NOUN
dpc-5172	237	9	is	be	AUX
dpc-5172	237	10	mediated	mediate	VERB
dpc-5172	237	11	by	by	ADP
dpc-5172	237	12	well	well	ADV
dpc-5172	237	13	-	-	PUNCT
dpc-5172	237	14	established	establish	VERB
dpc-5172	237	15	biochemical	biochemical	ADJ
dpc-5172	237	16	pathways	pathway	NOUN
dpc-5172	237	17	in	in	ADP
dpc-5172	237	18	keratinocytes	keratinocyte	NOUN
dpc-5172	237	19	.	.	PUNCT
dpc-5172	238	1	tretinoin	tretinoin	PROPN
dpc-5172	238	2	regulates	regulate	VERB
dpc-5172	238	3	epidermal	epidermal	ADJ
dpc-5172	238	4	cell	cell	NOUN
dpc-5172	238	5	proliferation	proliferation	NOUN
dpc-5172	238	6	and	and	CCONJ
dpc-5172	238	7	differentiation	differentiation	NOUN
dpc-5172	238	8	by	by	ADP
dpc-5172	238	9	interacting	interact	VERB
dpc-5172	238	10	with	with	ADP
dpc-5172	238	11	cellular	cellular	ADJ
dpc-5172	238	12	retinoic	retinoic	ADJ
dpc-5172	238	13	acid	acid	NOUN
dpc-5172	238	14	–	–	PUNCT
dpc-5172	238	15	binding	bind	VERB
dpc-5172	238	16	proteins	protein	NOUN
dpc-5172	238	17	,	,	PUNCT
dpc-5172	238	18	which	which	PRON
dpc-5172	238	19	function	function	VERB
dpc-5172	238	20	as	as	ADP
dpc-5172	238	21	receptors	receptor	NOUN
dpc-5172	238	22	for	for	ADP
dpc-5172	238	23	all	all	DET
dpc-5172	238	24	-	-	PUNCT
dpc-5172	238	25	trans	trans	ADJ
dpc-5172	238	26	-	-	ADJ
dpc-5172	238	27	retinoic	retinoic	ADJ
dpc-5172	238	28	acid	acid	NOUN
dpc-5172	238	29	.	.	PUNCT
dpc-5172	239	1	upon	upon	SCONJ
dpc-5172	239	2	binding	bind	VERB
dpc-5172	239	3	to	to	ADP
dpc-5172	239	4	specific	specific	ADJ
dpc-5172	239	5	cytosolic	cytosolic	ADJ
dpc-5172	239	6	receptors	receptor	NOUN
dpc-5172	239	7	,	,	PUNCT
dpc-5172	239	8	tretinoin	tretinoin	PROPN
dpc-5172	239	9	translocates	translocate	NOUN
dpc-5172	239	10	to	to	ADP
dpc-5172	239	11	the	the	DET
dpc-5172	239	12	nucleus	nucleus	NOUN
dpc-5172	239	13	,	,	PUNCT
dpc-5172	239	14	where	where	SCONJ
dpc-5172	239	15	it	it	PRON
dpc-5172	239	16	modulates	modulate	VERB
dpc-5172	239	17	protein	protein	NOUN
dpc-5172	239	18	synthesis	synthesis	NOUN
dpc-5172	239	19	and	and	CCONJ
dpc-5172	239	20	enhances	enhance	VERB
dpc-5172	239	21	the	the	DET
dpc-5172	239	22	features	feature	NOUN
dpc-5172	239	23	of	of	ADP
dpc-5172	239	24	photodamaged	photodamage	VERB
dpc-5172	239	25	skin	skin	NOUN
dpc-5172	239	26	[	[	X
dpc-5172	239	27	1,5	1,5	NUM
dpc-5172	239	28	]	]	PUNCT
dpc-5172	239	29	.	.	PUNCT
dpc-5172	240	1	tretinoin	tretinoin	PROPN
dpc-5172	240	2	exerts	exert	VERB
dpc-5172	240	3	its	its	PRON
dpc-5172	240	4	primary	primary	ADJ
dpc-5172	240	5	therapeutic	therapeutic	ADJ
dpc-5172	240	6	effects	effect	NOUN
dpc-5172	240	7	through	through	ADP
dpc-5172	240	8	retinoic	retinoic	ADJ
dpc-5172	240	9	acid	acid	NOUN
dpc-5172	240	10	receptors	receptor	NOUN
dpc-5172	240	11	(	(	PUNCT
dpc-5172	240	12	rars	rar	NOUN
dpc-5172	240	13	)	)	PUNCT
dpc-5172	240	14	,	,	PUNCT
dpc-5172	240	15	with	with	ADP
dpc-5172	240	16	rar	rar	NOUN
dpc-5172	240	17	-	-	PUNCT
dpc-5172	240	18	γ	γ	NOUN
dpc-5172	240	19	being	be	AUX
dpc-5172	240	20	the	the	DET
dpc-5172	240	21	8	8	NUM
dpc-5172	240	22	review	review	NOUN
dpc-5172	240	23	|	|	ADV
dpc-5172	240	24	dermatol	dermatol	ADJ
dpc-5172	240	25	pract	pract	NOUN
dpc-5172	240	26	concept	concept	NOUN
dpc-5172	240	27	.	.	PUNCT
dpc-5172	241	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	241	2	limited	limit	VERB
dpc-5172	241	3	by	by	ADP
dpc-5172	241	4	small	small	ADJ
dpc-5172	241	5	sample	sample	NOUN
dpc-5172	241	6	sizes	size	NOUN
dpc-5172	241	7	and	and	CCONJ
dpc-5172	241	8	nonrandomized	nonrandomize	VERB
dpc-5172	241	9	designs	design	NOUN
dpc-5172	241	10	,	,	PUNCT
dpc-5172	241	11	which	which	PRON
dpc-5172	241	12	reduce	reduce	VERB
dpc-5172	241	13	the	the	DET
dpc-5172	241	14	overall	overall	ADJ
dpc-5172	241	15	strength	strength	NOUN
dpc-5172	241	16	of	of	ADP
dpc-5172	241	17	the	the	DET
dpc-5172	241	18	evidence	evidence	NOUN
dpc-5172	241	19	because	because	SCONJ
dpc-5172	241	20	of	of	ADP
dpc-5172	241	21	the	the	DET
dpc-5172	241	22	potential	potential	NOUN
dpc-5172	241	23	for	for	ADP
dpc-5172	241	24	bias	bias	NOUN
dpc-5172	241	25	[	[	X
dpc-5172	241	26	9,10	9,10	NUM
dpc-5172	241	27	]	]	X
dpc-5172	241	28	.	.	PUNCT
dpc-5172	242	1	cosmetic	cosmetic	ADJ
dpc-5172	242	2	procedures	procedure	NOUN
dpc-5172	242	3	such	such	ADJ
dpc-5172	242	4	as	as	ADP
dpc-5172	242	5	microneedling	microneedling	NOUN
dpc-5172	242	6	and	and	CCONJ
dpc-5172	242	7	laser	laser	NOUN
dpc-5172	242	8	therapy	therapy	NOUN
dpc-5172	242	9	,	,	PUNCT
dpc-5172	242	10	either	either	CCONJ
dpc-5172	242	11	as	as	ADP
dpc-5172	242	12	standalone	standalone	ADJ
dpc-5172	242	13	treatments	treatment	NOUN
dpc-5172	242	14	or	or	CCONJ
dpc-5172	242	15	in	in	ADP
dpc-5172	242	16	combination	combination	NOUN
dpc-5172	242	17	with	with	ADP
dpc-5172	242	18	tretinoin	tretinoin	NOUN
dpc-5172	242	19	,	,	PUNCT
dpc-5172	242	20	are	be	AUX
dpc-5172	242	21	also	also	ADV
dpc-5172	242	22	effective	effective	ADJ
dpc-5172	242	23	options	option	NOUN
dpc-5172	242	24	for	for	ADP
dpc-5172	242	25	individuals	individual	NOUN
dpc-5172	242	26	seeking	seek	VERB
dpc-5172	242	27	rejuvenation	rejuvenation	NOUN
dpc-5172	242	28	strategies	strategy	NOUN
dpc-5172	242	29	with	with	ADP
dpc-5172	242	30	reduced	reduced	ADJ
dpc-5172	242	31	irritation	irritation	NOUN
dpc-5172	242	32	.	.	PUNCT
dpc-5172	243	1	although	although	SCONJ
dpc-5172	243	2	tretinoin	tretinoin	PROPN
dpc-5172	243	3	remains	remain	VERB
dpc-5172	243	4	a	a	DET
dpc-5172	243	5	widely	widely	ADV
dpc-5172	243	6	used	use	VERB
dpc-5172	243	7	and	and	CCONJ
dpc-5172	243	8	effective	effective	ADJ
dpc-5172	243	9	intervention	intervention	NOUN
dpc-5172	243	10	,	,	PUNCT
dpc-5172	243	11	emerging	emerge	VERB
dpc-5172	243	12	therapies	therapy	NOUN
dpc-5172	243	13	may	may	AUX
dpc-5172	243	14	offer	offer	VERB
dpc-5172	243	15	advantages	advantage	NOUN
dpc-5172	243	16	over	over	ADP
dpc-5172	243	17	tretinoin	tretinoin	NOUN
dpc-5172	243	18	in	in	ADP
dpc-5172	243	19	terms	term	NOUN
dpc-5172	243	20	of	of	ADP
dpc-5172	243	21	efficacy	efficacy	NOUN
dpc-5172	243	22	and	and	CCONJ
dpc-5172	243	23	tolerability	tolerability	NOUN
dpc-5172	243	24	.	.	PUNCT
dpc-5172	244	1	future	future	ADJ
dpc-5172	244	2	research	research	NOUN
dpc-5172	244	3	should	should	AUX
dpc-5172	244	4	include	include	VERB
dpc-5172	244	5	larger	large	ADJ
dpc-5172	244	6	,	,	PUNCT
dpc-5172	244	7	long	long	ADJ
dpc-5172	244	8	-	-	PUNCT
dpc-5172	244	9	term	term	NOUN
dpc-5172	244	10	clinical	clinical	ADJ
dpc-5172	244	11	trials	trial	NOUN
dpc-5172	244	12	to	to	PART
dpc-5172	244	13	compare	compare	VERB
dpc-5172	244	14	these	these	DET
dpc-5172	244	15	therapies	therapy	NOUN
dpc-5172	244	16	and	and	CCONJ
dpc-5172	244	17	identify	identify	VERB
dpc-5172	244	18	optimal	optimal	ADJ
dpc-5172	244	19	treatment	treatment	NOUN
dpc-5172	244	20	regimens	regimen	NOUN
dpc-5172	244	21	for	for	ADP
dpc-5172	244	22	managing	manage	VERB
dpc-5172	244	23	photoaging	photoaging	NOUN
dpc-5172	244	24	.	.	PUNCT
dpc-5172	245	1	to	to	PART
dpc-5172	245	2	assist	assist	VERB
dpc-5172	245	3	clinicians	clinician	NOUN
dpc-5172	245	4	in	in	ADP
dpc-5172	245	5	translating	translate	VERB
dpc-5172	245	6	these	these	DET
dpc-5172	245	7	findings	finding	NOUN
dpc-5172	245	8	into	into	ADP
dpc-5172	245	9	daily	daily	ADJ
dpc-5172	245	10	practice	practice	NOUN
dpc-5172	245	11	,	,	PUNCT
dpc-5172	245	12	table	table	NOUN
dpc-5172	245	13	2	2	NUM
dpc-5172	245	14	summarizes	summarize	NOUN
dpc-5172	245	15	practical	practical	ADJ
dpc-5172	245	16	considerations	consideration	NOUN
dpc-5172	245	17	and	and	CCONJ
dpc-5172	245	18	recommendations	recommendation	NOUN
dpc-5172	245	19	for	for	ADP
dpc-5172	245	20	the	the	DET
dpc-5172	245	21	safe	safe	ADJ
dpc-5172	245	22	and	and	CCONJ
dpc-5172	245	23	effective	effective	ADJ
dpc-5172	245	24	use	use	NOUN
dpc-5172	245	25	of	of	ADP
dpc-5172	245	26	topical	topical	ADJ
dpc-5172	245	27	tretinoin	tretinoin	NOUN
dpc-5172	245	28	in	in	ADP
dpc-5172	245	29	treating	treat	VERB
dpc-5172	245	30	photodamaged	photodamage	VERB
dpc-5172	245	31	facial	facial	ADJ
dpc-5172	245	32	skin	skin	NOUN
dpc-5172	245	33	.	.	PUNCT
dpc-5172	246	1	limitations	limitation	NOUN
dpc-5172	246	2	our	our	PRON
dpc-5172	246	3	study	study	NOUN
dpc-5172	246	4	has	have	VERB
dpc-5172	246	5	several	several	ADJ
dpc-5172	246	6	limitations	limitation	NOUN
dpc-5172	246	7	.	.	PUNCT
dpc-5172	247	1	first	first	ADV
dpc-5172	247	2	,	,	PUNCT
dpc-5172	247	3	the	the	DET
dpc-5172	247	4	randomized	randomized	ADJ
dpc-5172	247	5	controlled	control	VERB
dpc-5172	247	6	trials	trial	NOUN
dpc-5172	247	7	included	include	VERB
dpc-5172	247	8	in	in	ADP
dpc-5172	247	9	this	this	PRON
dpc-5172	247	10	meta	meta	ADJ
dpc-5172	247	11	-	-	PUNCT
dpc-5172	247	12	analysis	analysis	NOUN
dpc-5172	247	13	exhibited	exhibit	VERB
dpc-5172	247	14	variability	variability	NOUN
dpc-5172	247	15	in	in	ADP
dpc-5172	247	16	terms	term	NOUN
dpc-5172	247	17	of	of	ADP
dpc-5172	247	18	their	their	PRON
dpc-5172	247	19	design	design	NOUN
dpc-5172	247	20	and	and	CCONJ
dpc-5172	247	21	methodology	methodology	NOUN
dpc-5172	247	22	,	,	PUNCT
dpc-5172	247	23	including	include	VERB
dpc-5172	247	24	differences	difference	NOUN
dpc-5172	247	25	in	in	ADP
dpc-5172	247	26	treatment	treatment	NOUN
dpc-5172	247	27	formulation	formulation	NOUN
dpc-5172	247	28	,	,	PUNCT
dpc-5172	247	29	dosage	dosage	NOUN
dpc-5172	247	30	,	,	PUNCT
dpc-5172	247	31	and	and	CCONJ
dpc-5172	247	32	duration	duration	NOUN
dpc-5172	247	33	.	.	PUNCT
dpc-5172	248	1	these	these	DET
dpc-5172	248	2	inconsistencies	inconsistency	NOUN
dpc-5172	248	3	may	may	AUX
dpc-5172	248	4	have	have	AUX
dpc-5172	248	5	contributed	contribute	VERB
dpc-5172	248	6	to	to	ADP
dpc-5172	248	7	heterogeneity	heterogeneity	NOUN
dpc-5172	248	8	in	in	ADP
dpc-5172	248	9	the	the	DET
dpc-5172	248	10	reported	report	VERB
dpc-5172	248	11	outcomes	outcome	NOUN
dpc-5172	248	12	and	and	CCONJ
dpc-5172	248	13	could	could	AUX
dpc-5172	248	14	affect	affect	VERB
dpc-5172	248	15	the	the	DET
dpc-5172	248	16	interpretability	interpretability	NOUN
dpc-5172	248	17	of	of	ADP
dpc-5172	248	18	their	their	PRON
dpc-5172	248	19	findings	finding	NOUN
dpc-5172	248	20	.	.	PUNCT
dpc-5172	249	1	although	although	SCONJ
dpc-5172	249	2	this	this	DET
dpc-5172	249	3	study	study	NOUN
dpc-5172	249	4	standardized	standardize	VERB
dpc-5172	249	5	outcome	outcome	NOUN
dpc-5172	249	6	measurements	measurement	NOUN
dpc-5172	249	7	by	by	ADP
dpc-5172	249	8	using	use	VERB
dpc-5172	249	9	percentage	percentage	NOUN
dpc-5172	249	10	improvements	improvement	NOUN
dpc-5172	249	11	in	in	ADP
dpc-5172	249	12	wrinkle	wrinkle	NOUN
dpc-5172	249	13	appearance	appearance	NOUN
dpc-5172	249	14	,	,	PUNCT
dpc-5172	249	15	the	the	DET
dpc-5172	249	16	initial	initial	ADJ
dpc-5172	249	17	assessment	assessment	NOUN
dpc-5172	249	18	scales	scale	VERB
dpc-5172	249	19	varied	varied	ADJ
dpc-5172	249	20	across	across	ADP
dpc-5172	249	21	the	the	DET
dpc-5172	249	22	trials	trial	NOUN
dpc-5172	249	23	.	.	PUNCT
dpc-5172	250	1	additional	additional	ADJ
dpc-5172	250	2	variations	variation	NOUN
dpc-5172	250	3	in	in	ADP
dpc-5172	250	4	dosages	dosage	NOUN
dpc-5172	250	5	,	,	PUNCT
dpc-5172	250	6	treatment	treatment	NOUN
dpc-5172	250	7	durations	duration	NOUN
dpc-5172	250	8	,	,	PUNCT
dpc-5172	250	9	and	and	CCONJ
dpc-5172	250	10	drug	drug	NOUN
dpc-5172	250	11	vehicles	vehicle	NOUN
dpc-5172	250	12	may	may	AUX
dpc-5172	250	13	have	have	AUX
dpc-5172	250	14	influenced	influence	VERB
dpc-5172	250	15	the	the	DET
dpc-5172	250	16	observed	observe	VERB
dpc-5172	250	17	heterogeneity	heterogeneity	NOUN
dpc-5172	250	18	in	in	ADP
dpc-5172	250	19	fine	fine	ADJ
dpc-5172	250	20	wrinkle	wrinkle	NOUN
dpc-5172	250	21	outcomes	outcome	NOUN
dpc-5172	250	22	and	and	CCONJ
dpc-5172	250	23	affected	affect	VERB
dpc-5172	250	24	the	the	DET
dpc-5172	250	25	consistency	consistency	NOUN
dpc-5172	250	26	of	of	ADP
dpc-5172	250	27	estimated	estimate	VERB
dpc-5172	250	28	treatment	treatment	NOUN
dpc-5172	250	29	effects	effect	NOUN
dpc-5172	250	30	.	.	PUNCT
dpc-5172	251	1	to	to	PART
dpc-5172	251	2	address	address	VERB
dpc-5172	251	3	this	this	PRON
dpc-5172	251	4	,	,	PUNCT
dpc-5172	251	5	we	we	PRON
dpc-5172	251	6	employed	employ	VERB
dpc-5172	251	7	a	a	DET
dpc-5172	251	8	random	random	ADJ
dpc-5172	251	9	effects	effect	NOUN
dpc-5172	251	10	model	model	NOUN
dpc-5172	251	11	and	and	CCONJ
dpc-5172	251	12	conducted	conduct	VERB
dpc-5172	251	13	sensitivity	sensitivity	NOUN
dpc-5172	251	14	analyses	analysis	NOUN
dpc-5172	251	15	.	.	PUNCT
dpc-5172	252	1	second	second	ADJ
dpc-5172	252	2	,	,	PUNCT
dpc-5172	252	3	the	the	DET
dpc-5172	252	4	potential	potential	NOUN
dpc-5172	252	5	for	for	ADP
dpc-5172	252	6	reporting	reporting	NOUN
dpc-5172	252	7	or	or	CCONJ
dpc-5172	252	8	publication	publication	NOUN
dpc-5172	252	9	bias	bias	NOUN
dpc-5172	252	10	can	can	AUX
dpc-5172	252	11	not	not	PART
dpc-5172	252	12	be	be	AUX
dpc-5172	252	13	excluded	exclude	VERB
dpc-5172	252	14	.	.	PUNCT
dpc-5172	253	1	publication	publication	NOUN
dpc-5172	253	2	bias	bias	NOUN
dpc-5172	253	3	occurs	occur	VERB
dpc-5172	253	4	when	when	SCONJ
dpc-5172	253	5	positive	positive	ADJ
dpc-5172	253	6	results	result	NOUN
dpc-5172	253	7	are	be	AUX
dpc-5172	253	8	more	more	ADV
dpc-5172	253	9	likely	likely	ADJ
dpc-5172	253	10	to	to	PART
dpc-5172	253	11	be	be	AUX
dpc-5172	253	12	published	publish	VERB
dpc-5172	253	13	than	than	SCONJ
dpc-5172	253	14	are	be	AUX
dpc-5172	253	15	negative	negative	ADJ
dpc-5172	253	16	or	or	CCONJ
dpc-5172	253	17	null	null	ADJ
dpc-5172	253	18	findings	finding	NOUN
dpc-5172	253	19	,	,	PUNCT
dpc-5172	253	20	leading	lead	VERB
dpc-5172	253	21	to	to	ADP
dpc-5172	253	22	an	an	DET
dpc-5172	253	23	overestimation	overestimation	NOUN
dpc-5172	253	24	of	of	ADP
dpc-5172	253	25	treatment	treatment	NOUN
dpc-5172	253	26	efficacy	efficacy	NOUN
dpc-5172	253	27	.	.	PUNCT
dpc-5172	254	1	in	in	ADP
dpc-5172	254	2	our	our	PRON
dpc-5172	254	3	analysis	analysis	NOUN
dpc-5172	254	4	,	,	PUNCT
dpc-5172	254	5	evidence	evidence	NOUN
dpc-5172	254	6	of	of	ADP
dpc-5172	254	7	publication	publication	NOUN
dpc-5172	254	8	bias	bias	NOUN
dpc-5172	254	9	was	be	AUX
dpc-5172	254	10	observed	observe	VERB
dpc-5172	254	11	in	in	ADP
dpc-5172	254	12	trials	trial	NOUN
dpc-5172	254	13	assessing	assess	VERB
dpc-5172	254	14	improvements	improvement	NOUN
dpc-5172	254	15	in	in	ADP
dpc-5172	254	16	fine	fine	ADJ
dpc-5172	254	17	wrinkles	wrinkle	NOUN
dpc-5172	254	18	,	,	PUNCT
dpc-5172	254	19	suggesting	suggest	VERB
dpc-5172	254	20	that	that	SCONJ
dpc-5172	254	21	these	these	DET
dpc-5172	254	22	results	result	NOUN
dpc-5172	254	23	should	should	AUX
dpc-5172	254	24	be	be	AUX
dpc-5172	254	25	interpreted	interpret	VERB
dpc-5172	254	26	with	with	ADP
dpc-5172	254	27	caution	caution	NOUN
dpc-5172	254	28	.	.	PUNCT
dpc-5172	255	1	third	third	ADJ
dpc-5172	255	2	,	,	PUNCT
dpc-5172	255	3	most	most	ADV
dpc-5172	255	4	included	include	VERB
dpc-5172	255	5	trials	trial	NOUN
dpc-5172	255	6	lacked	lack	VERB
dpc-5172	255	7	long	long	ADJ
dpc-5172	255	8	-	-	PUNCT
dpc-5172	255	9	term	term	NOUN
dpc-5172	255	10	follow	follow	NOUN
dpc-5172	255	11	-	-	PUNCT
dpc-5172	255	12	up	up	ADP
dpc-5172	255	13	data	datum	NOUN
dpc-5172	255	14	.	.	PUNCT
dpc-5172	256	1	the	the	DET
dpc-5172	256	2	longest	long	ADJ
dpc-5172	256	3	treatment	treatment	NOUN
dpc-5172	256	4	duration	duration	NOUN
dpc-5172	256	5	reported	report	VERB
dpc-5172	256	6	was	be	AUX
dpc-5172	256	7	two	two	NUM
dpc-5172	256	8	years	year	NOUN
dpc-5172	256	9	,	,	PUNCT
dpc-5172	256	10	thus	thus	ADV
dpc-5172	256	11	limiting	limit	VERB
dpc-5172	256	12	our	our	PRON
dpc-5172	256	13	ability	ability	NOUN
dpc-5172	256	14	to	to	PART
dpc-5172	256	15	evaluate	evaluate	VERB
dpc-5172	256	16	the	the	DET
dpc-5172	256	17	sustained	sustained	ADJ
dpc-5172	256	18	effectiveness	effectiveness	NOUN
dpc-5172	256	19	and	and	CCONJ
dpc-5172	256	20	long	long	ADJ
dpc-5172	256	21	-	-	PUNCT
dpc-5172	256	22	term	term	NOUN
dpc-5172	256	23	safety	safety	NOUN
dpc-5172	256	24	of	of	ADP
dpc-5172	256	25	topical	topical	ADJ
dpc-5172	256	26	retinoids	retinoid	NOUN
dpc-5172	256	27	for	for	ADP
dpc-5172	256	28	treating	treat	VERB
dpc-5172	256	29	fine	fine	ADJ
dpc-5172	256	30	and	and	CCONJ
dpc-5172	256	31	coarse	coarse	ADJ
dpc-5172	256	32	wrinkles	wrinkle	NOUN
dpc-5172	256	33	.	.	PUNCT
dpc-5172	257	1	although	although	SCONJ
dpc-5172	257	2	patient	patient	NOUN
dpc-5172	257	3	-	-	PUNCT
dpc-5172	257	4	reported	report	VERB
dpc-5172	257	5	outcomes	outcome	NOUN
dpc-5172	257	6	indicated	indicate	VERB
dpc-5172	257	7	satisfaction	satisfaction	NOUN
dpc-5172	257	8	with	with	ADP
dpc-5172	257	9	tretinoin	tretinoin	PROPN
dpc-5172	257	10	treatment	treatment	NOUN
dpc-5172	257	11	,	,	PUNCT
dpc-5172	257	12	the	the	DET
dpc-5172	257	13	trials	trial	NOUN
dpc-5172	257	14	did	do	AUX
dpc-5172	257	15	not	not	PART
dpc-5172	257	16	capture	capture	VERB
dpc-5172	257	17	specific	specific	ADJ
dpc-5172	257	18	quality	quality	NOUN
dpc-5172	257	19	-	-	PUNCT
dpc-5172	257	20	of	of	ADP
dpc-5172	257	21	-	-	PUNCT
dpc-5172	257	22	life	life	NOUN
dpc-5172	257	23	feedback	feedback	NOUN
dpc-5172	257	24	,	,	PUNCT
dpc-5172	257	25	such	such	ADJ
dpc-5172	257	26	as	as	ADP
dpc-5172	257	27	that	that	PRON
dpc-5172	257	28	regarding	regard	VERB
dpc-5172	257	29	skin	skin	NOUN
dpc-5172	257	30	comfort	comfort	NOUN
dpc-5172	257	31	or	or	CCONJ
dpc-5172	257	32	psychological	psychological	ADJ
dpc-5172	257	33	and	and	CCONJ
dpc-5172	257	34	emotional	emotional	ADJ
dpc-5172	257	35	impacts	impact	NOUN
dpc-5172	257	36	.	.	PUNCT
dpc-5172	258	1	future	future	ADJ
dpc-5172	258	2	studies	study	NOUN
dpc-5172	258	3	should	should	AUX
dpc-5172	258	4	incorporate	incorporate	VERB
dpc-5172	258	5	validated	validated	ADJ
dpc-5172	258	6	qol	qol	NOUN
dpc-5172	258	7	instruments	instrument	NOUN
dpc-5172	258	8	,	,	PUNCT
dpc-5172	258	9	such	such	ADJ
dpc-5172	258	10	as	as	ADP
dpc-5172	258	11	the	the	DET
dpc-5172	258	12	dermatology	dermatology	NOUN
dpc-5172	258	13	life	life	NOUN
dpc-5172	258	14	quality	quality	NOUN
dpc-5172	258	15	index	index	NOUN
dpc-5172	258	16	,	,	PUNCT
dpc-5172	258	17	to	to	PART
dpc-5172	258	18	better	well	ADV
dpc-5172	258	19	assess	assess	VERB
dpc-5172	258	20	the	the	DET
dpc-5172	258	21	real	real	ADJ
dpc-5172	258	22	-	-	PUNCT
dpc-5172	258	23	world	world	NOUN
dpc-5172	258	24	impact	impact	NOUN
dpc-5172	258	25	of	of	ADP
dpc-5172	258	26	tretinoin	tretinoin	PROPN
dpc-5172	258	27	therapy	therapy	NOUN
dpc-5172	258	28	.	.	PUNCT
dpc-5172	259	1	reactions	reaction	NOUN
dpc-5172	259	2	were	be	AUX
dpc-5172	259	3	sufficiently	sufficiently	ADV
dpc-5172	259	4	bothersome	bothersome	ADJ
dpc-5172	259	5	to	to	PART
dpc-5172	259	6	result	result	VERB
dpc-5172	259	7	in	in	ADP
dpc-5172	259	8	temporary	temporary	ADJ
dpc-5172	259	9	discontinuation	discontinuation	NOUN
dpc-5172	259	10	or	or	CCONJ
dpc-5172	259	11	modification	modification	NOUN
dpc-5172	259	12	of	of	ADP
dpc-5172	259	13	the	the	DET
dpc-5172	259	14	treatment	treatment	NOUN
dpc-5172	259	15	regimen	regiman	NOUN
dpc-5172	259	16	.	.	PUNCT
dpc-5172	260	1	previous	previous	ADJ
dpc-5172	260	2	studies	study	NOUN
dpc-5172	260	3	have	have	AUX
dpc-5172	260	4	suggested	suggest	VERB
dpc-5172	260	5	that	that	SCONJ
dpc-5172	260	6	irritation	irritation	NOUN
dpc-5172	260	7	may	may	AUX
dpc-5172	260	8	be	be	AUX
dpc-5172	260	9	mitigated	mitigate	VERB
dpc-5172	260	10	by	by	ADP
dpc-5172	260	11	gradually	gradually	ADV
dpc-5172	260	12	escalating	escalate	VERB
dpc-5172	260	13	the	the	DET
dpc-5172	260	14	dose	dose	NOUN
dpc-5172	260	15	,	,	PUNCT
dpc-5172	260	16	using	use	VERB
dpc-5172	260	17	moisturizers	moisturizer	NOUN
dpc-5172	260	18	concurrently	concurrently	ADV
dpc-5172	260	19	,	,	PUNCT
dpc-5172	260	20	or	or	CCONJ
dpc-5172	260	21	applying	apply	VERB
dpc-5172	260	22	topical	topical	ADJ
dpc-5172	260	23	corticosteroids	corticosteroid	NOUN
dpc-5172	260	24	for	for	ADP
dpc-5172	260	25	shortterm	shortterm	NOUN
dpc-5172	260	26	relief	relief	NOUN
dpc-5172	261	1	[	[	X
dpc-5172	261	2	1,5,6	1,5,6	NUM
dpc-5172	261	3	]	]	X
dpc-5172	261	4	.	.	PUNCT
dpc-5172	262	1	nonetheless	nonetheless	ADV
dpc-5172	262	2	,	,	PUNCT
dpc-5172	262	3	further	further	ADJ
dpc-5172	262	4	research	research	NOUN
dpc-5172	262	5	is	be	AUX
dpc-5172	262	6	required	require	VERB
dpc-5172	262	7	to	to	PART
dpc-5172	262	8	optimize	optimize	VERB
dpc-5172	262	9	treatment	treatment	NOUN
dpc-5172	262	10	protocols	protocol	NOUN
dpc-5172	262	11	that	that	PRON
dpc-5172	262	12	improve	improve	VERB
dpc-5172	262	13	long	long	ADJ
dpc-5172	262	14	-	-	PUNCT
dpc-5172	262	15	term	term	NOUN
dpc-5172	262	16	adherence	adherence	NOUN
dpc-5172	262	17	without	without	ADP
dpc-5172	262	18	reducing	reduce	VERB
dpc-5172	262	19	therapeutic	therapeutic	ADJ
dpc-5172	262	20	efficacy	efficacy	NOUN
dpc-5172	262	21	.	.	PUNCT
dpc-5172	263	1	patient	patient	ADJ
dpc-5172	263	2	adherence	adherence	NOUN
dpc-5172	263	3	remains	remain	VERB
dpc-5172	263	4	a	a	DET
dpc-5172	263	5	key	key	ADJ
dpc-5172	263	6	challenge	challenge	NOUN
dpc-5172	263	7	in	in	ADP
dpc-5172	263	8	tretinoin	tretinoin	NOUN
dpc-5172	263	9	treatment	treatment	NOUN
dpc-5172	263	10	because	because	SCONJ
dpc-5172	263	11	of	of	ADP
dpc-5172	263	12	the	the	DET
dpc-5172	263	13	high	high	ADJ
dpc-5172	263	14	frequency	frequency	NOUN
dpc-5172	263	15	of	of	ADP
dpc-5172	263	16	adverse	adverse	ADJ
dpc-5172	263	17	effects	effect	NOUN
dpc-5172	263	18	.	.	PUNCT
dpc-5172	264	1	because	because	SCONJ
dpc-5172	264	2	patient	patient	ADJ
dpc-5172	264	3	adherence	adherence	NOUN
dpc-5172	264	4	is	be	AUX
dpc-5172	264	5	a	a	DET
dpc-5172	264	6	critical	critical	ADJ
dpc-5172	264	7	determinant	determinant	NOUN
dpc-5172	264	8	of	of	ADP
dpc-5172	264	9	clinical	clinical	ADJ
dpc-5172	264	10	outcomes	outcome	NOUN
dpc-5172	264	11	,	,	PUNCT
dpc-5172	264	12	education	education	NOUN
dpc-5172	264	13	and	and	CCONJ
dpc-5172	264	14	individualized	individualized	ADJ
dpc-5172	264	15	management	management	NOUN
dpc-5172	264	16	strategies	strategy	NOUN
dpc-5172	264	17	are	be	AUX
dpc-5172	264	18	essential	essential	ADJ
dpc-5172	264	19	.	.	PUNCT
dpc-5172	265	1	ensuring	ensure	VERB
dpc-5172	265	2	that	that	SCONJ
dpc-5172	265	3	patients	patient	NOUN
dpc-5172	265	4	anticipate	anticipate	VERB
dpc-5172	265	5	and	and	CCONJ
dpc-5172	265	6	are	be	AUX
dpc-5172	265	7	able	able	ADJ
dpc-5172	265	8	to	to	PART
dpc-5172	265	9	manage	manage	VERB
dpc-5172	265	10	transient	transient	ADJ
dpc-5172	265	11	irritation	irritation	NOUN
dpc-5172	265	12	may	may	AUX
dpc-5172	265	13	enhance	enhance	VERB
dpc-5172	265	14	treatment	treatment	NOUN
dpc-5172	265	15	persistence	persistence	NOUN
dpc-5172	265	16	.	.	PUNCT
dpc-5172	266	1	additional	additional	ADJ
dpc-5172	266	2	investigations	investigation	NOUN
dpc-5172	266	3	identifying	identify	VERB
dpc-5172	266	4	alternative	alternative	ADJ
dpc-5172	266	5	formulations	formulation	NOUN
dpc-5172	266	6	,	,	PUNCT
dpc-5172	266	7	such	such	ADJ
dpc-5172	266	8	as	as	ADP
dpc-5172	266	9	those	those	PRON
dpc-5172	266	10	with	with	ADP
dpc-5172	266	11	lower	low	ADJ
dpc-5172	266	12	tretinoin	tretinoin	NOUN
dpc-5172	266	13	concentrations	concentration	NOUN
dpc-5172	266	14	or	or	CCONJ
dpc-5172	266	15	newer	new	ADJ
dpc-5172	266	16	retinoid	retinoid	NOUN
dpc-5172	266	17	derivatives	derivative	NOUN
dpc-5172	266	18	with	with	ADP
dpc-5172	266	19	improved	improved	ADJ
dpc-5172	266	20	tolerability	tolerability	NOUN
dpc-5172	266	21	,	,	PUNCT
dpc-5172	266	22	could	could	AUX
dpc-5172	266	23	help	help	VERB
dpc-5172	266	24	address	address	VERB
dpc-5172	266	25	this	this	PRON
dpc-5172	266	26	.	.	PUNCT
dpc-5172	267	1	in	in	ADP
dpc-5172	267	2	the	the	DET
dpc-5172	267	3	current	current	ADJ
dpc-5172	267	4	study	study	NOUN
dpc-5172	267	5	,	,	PUNCT
dpc-5172	267	6	common	common	ADJ
dpc-5172	267	7	adverse	adverse	ADJ
dpc-5172	267	8	reactions	reaction	NOUN
dpc-5172	267	9	to	to	ADP
dpc-5172	267	10	topical	topical	ADJ
dpc-5172	267	11	tretinoin	tretinoin	NOUN
dpc-5172	267	12	were	be	AUX
dpc-5172	267	13	generally	generally	ADV
dpc-5172	267	14	resolved	resolve	VERB
dpc-5172	267	15	with	with	ADP
dpc-5172	267	16	continued	continue	VERB
dpc-5172	267	17	use	use	NOUN
dpc-5172	267	18	or	or	CCONJ
dpc-5172	267	19	appropriate	appropriate	ADJ
dpc-5172	267	20	supportive	supportive	ADJ
dpc-5172	267	21	care	care	NOUN
dpc-5172	267	22	.	.	PUNCT
dpc-5172	268	1	some	some	PRON
dpc-5172	268	2	have	have	AUX
dpc-5172	268	3	speculated	speculate	VERB
dpc-5172	268	4	that	that	SCONJ
dpc-5172	268	5	the	the	DET
dpc-5172	268	6	irritation	irritation	NOUN
dpc-5172	268	7	and	and	CCONJ
dpc-5172	268	8	inflammation	inflammation	NOUN
dpc-5172	268	9	induced	induce	VERB
dpc-5172	268	10	by	by	ADP
dpc-5172	268	11	topical	topical	ADJ
dpc-5172	268	12	retinoids	retinoid	NOUN
dpc-5172	268	13	may	may	AUX
dpc-5172	268	14	contribute	contribute	VERB
dpc-5172	268	15	to	to	ADP
dpc-5172	268	16	wrinkle	wrinkle	NOUN
dpc-5172	268	17	improvement	improvement	NOUN
dpc-5172	268	18	because	because	SCONJ
dpc-5172	268	19	mild	mild	ADJ
dpc-5172	268	20	swelling	swelling	NOUN
dpc-5172	268	21	could	could	AUX
dpc-5172	268	22	temporarily	temporarily	ADV
dpc-5172	268	23	reduce	reduce	VERB
dpc-5172	268	24	the	the	DET
dpc-5172	268	25	appearance	appearance	NOUN
dpc-5172	268	26	of	of	ADP
dpc-5172	268	27	wrinkles	wrinkle	NOUN
dpc-5172	268	28	[	[	X
dpc-5172	268	29	1	1	NUM
dpc-5172	268	30	]	]	PUNCT
dpc-5172	268	31	.	.	PUNCT
dpc-5172	269	1	however	however	ADV
dpc-5172	269	2	,	,	PUNCT
dpc-5172	269	3	findings	finding	NOUN
dpc-5172	269	4	from	from	ADP
dpc-5172	269	5	the	the	DET
dpc-5172	269	6	trial	trial	NOUN
dpc-5172	269	7	by	by	ADP
dpc-5172	269	8	weiss	weiss	PROPN
dpc-5172	269	9	et	et	PROPN
dpc-5172	269	10	al	al	PROPN
dpc-5172	269	11	.	.	PUNCT
dpc-5172	270	1	[	[	X
dpc-5172	270	2	1	1	X
dpc-5172	270	3	]	]	PUNCT
dpc-5172	270	4	indicated	indicate	VERB
dpc-5172	270	5	that	that	SCONJ
dpc-5172	270	6	no	no	DET
dpc-5172	270	7	edema	edema	NOUN
dpc-5172	270	8	was	be	AUX
dpc-5172	270	9	observed	observe	VERB
dpc-5172	270	10	in	in	ADP
dpc-5172	270	11	post	post	ADJ
dpc-5172	270	12	-	-	ADJ
dpc-5172	270	13	treatment	treatment	ADJ
dpc-5172	270	14	skin	skin	NOUN
dpc-5172	270	15	biopsy	biopsy	NOUN
dpc-5172	270	16	specimens	specimen	NOUN
dpc-5172	270	17	,	,	PUNCT
dpc-5172	270	18	and	and	CCONJ
dpc-5172	270	19	no	no	DET
dpc-5172	270	20	improvement	improvement	NOUN
dpc-5172	270	21	in	in	ADP
dpc-5172	270	22	photoaging	photoage	VERB
dpc-5172	270	23	was	be	AUX
dpc-5172	270	24	noted	note	VERB
dpc-5172	270	25	in	in	ADP
dpc-5172	270	26	areas	area	NOUN
dpc-5172	270	27	affected	affect	VERB
dpc-5172	270	28	by	by	ADP
dpc-5172	270	29	tretinoin	tretinoin	NOUN
dpc-5172	270	30	-	-	PUNCT
dpc-5172	270	31	induced	induce	VERB
dpc-5172	270	32	dermatitis	dermatitis	NOUN
dpc-5172	270	33	.	.	PUNCT
dpc-5172	271	1	additional	additional	ADJ
dpc-5172	271	2	controlled	control	VERB
dpc-5172	271	3	trials	trial	NOUN
dpc-5172	271	4	reported	report	VERB
dpc-5172	271	5	that	that	SCONJ
dpc-5172	271	6	the	the	DET
dpc-5172	271	7	application	application	NOUN
dpc-5172	271	8	of	of	ADP
dpc-5172	271	9	other	other	ADJ
dpc-5172	271	10	irritants	irritant	NOUN
dpc-5172	271	11	,	,	PUNCT
dpc-5172	271	12	such	such	ADJ
dpc-5172	271	13	as	as	ADP
dpc-5172	271	14	salicylic	salicylic	ADJ
dpc-5172	271	15	acid	acid	NOUN
dpc-5172	271	16	,	,	PUNCT
dpc-5172	271	17	did	do	AUX
dpc-5172	271	18	not	not	PART
dpc-5172	271	19	produce	produce	VERB
dpc-5172	271	20	similar	similar	ADJ
dpc-5172	271	21	improvements	improvement	NOUN
dpc-5172	271	22	in	in	ADP
dpc-5172	271	23	photodamaged	photodamage	VERB
dpc-5172	271	24	skin	skin	NOUN
dpc-5172	271	25	[	[	X
dpc-5172	271	26	7	7	NUM
dpc-5172	271	27	]	]	PUNCT
dpc-5172	271	28	.	.	PUNCT
dpc-5172	272	1	moreover	moreover	ADV
dpc-5172	272	2	,	,	PUNCT
dpc-5172	272	3	olsen	olsen	PROPN
dpc-5172	272	4	et	et	PROPN
dpc-5172	272	5	al	al	PROPN
dpc-5172	272	6	.	.	PUNCT
dpc-5172	273	1	[	[	X
dpc-5172	273	2	5	5	NUM
dpc-5172	273	3	]	]	PUNCT
dpc-5172	273	4	identified	identify	VERB
dpc-5172	273	5	no	no	DET
dpc-5172	273	6	clinical	clinical	ADJ
dpc-5172	273	7	correlation	correlation	NOUN
dpc-5172	273	8	between	between	ADP
dpc-5172	273	9	irritation	irritation	NOUN
dpc-5172	273	10	and	and	CCONJ
dpc-5172	273	11	treatment	treatment	NOUN
dpc-5172	273	12	response	response	NOUN
dpc-5172	273	13	.	.	PUNCT
dpc-5172	274	1	in	in	ADP
dpc-5172	274	2	that	that	DET
dpc-5172	274	3	study	study	NOUN
dpc-5172	274	4	,	,	PUNCT
dpc-5172	274	5	only	only	ADV
dpc-5172	274	6	half	half	NOUN
dpc-5172	274	7	of	of	ADP
dpc-5172	274	8	the	the	DET
dpc-5172	274	9	patients	patient	NOUN
dpc-5172	274	10	who	who	PRON
dpc-5172	274	11	experienced	experience	VERB
dpc-5172	274	12	satisfactory	satisfactory	ADJ
dpc-5172	274	13	-	-	PUNCT
dpc-5172	274	14	to	to	ADP
dpc-5172	274	15	-	-	PUNCT
dpc-5172	274	16	excellent	excellent	ADJ
dpc-5172	274	17	improvement	improvement	NOUN
dpc-5172	274	18	rated	rate	VERB
dpc-5172	274	19	their	their	PRON
dpc-5172	274	20	irritation	irritation	NOUN
dpc-5172	274	21	level	level	NOUN
dpc-5172	274	22	as	as	ADP
dpc-5172	274	23	5	5	NUM
dpc-5172	274	24	or	or	CCONJ
dpc-5172	274	25	higher	high	ADJ
dpc-5172	274	26	on	on	ADP
dpc-5172	274	27	a	a	DET
dpc-5172	274	28	9	9	NUM
dpc-5172	274	29	-	-	PUNCT
dpc-5172	274	30	point	point	NOUN
dpc-5172	274	31	grading	grade	VERB
dpc-5172	274	32	scale	scale	NOUN
dpc-5172	274	33	[	[	X
dpc-5172	274	34	5	5	NUM
dpc-5172	274	35	]	]	PUNCT
dpc-5172	274	36	.	.	PUNCT
dpc-5172	275	1	the	the	DET
dpc-5172	275	2	long	long	ADJ
dpc-5172	275	3	-	-	PUNCT
dpc-5172	275	4	term	term	NOUN
dpc-5172	275	5	safety	safety	NOUN
dpc-5172	275	6	of	of	ADP
dpc-5172	275	7	tretinoin	tretinoin	PROPN
dpc-5172	275	8	treatment	treatment	NOUN
dpc-5172	275	9	was	be	AUX
dpc-5172	275	10	assessed	assess	VERB
dpc-5172	275	11	in	in	ADP
dpc-5172	275	12	a	a	DET
dpc-5172	275	13	trial	trial	NOUN
dpc-5172	275	14	conducted	conduct	VERB
dpc-5172	275	15	by	by	ADP
dpc-5172	275	16	kang	kang	PROPN
dpc-5172	275	17	et	et	PROPN
dpc-5172	275	18	al	al	PROPN
dpc-5172	275	19	.	.	PUNCT
dpc-5172	276	1	[	[	X
dpc-5172	276	2	4	4	NUM
dpc-5172	276	3	]	]	PUNCT
dpc-5172	276	4	.	.	PUNCT
dpc-5172	277	1	over	over	ADP
dpc-5172	277	2	a	a	DET
dpc-5172	277	3	2	2	NUM
dpc-5172	277	4	-	-	PUNCT
dpc-5172	277	5	year	year	NOUN
dpc-5172	277	6	treatment	treatment	NOUN
dpc-5172	277	7	period	period	NOUN
dpc-5172	277	8	,	,	PUNCT
dpc-5172	277	9	minimal	minimal	ADJ
dpc-5172	277	10	histological	histological	ADJ
dpc-5172	277	11	changes	change	NOUN
dpc-5172	277	12	were	be	AUX
dpc-5172	277	13	observed	observe	VERB
dpc-5172	277	14	in	in	ADP
dpc-5172	277	15	the	the	DET
dpc-5172	277	16	skin	skin	NOUN
dpc-5172	277	17	of	of	ADP
dpc-5172	277	18	most	most	ADJ
dpc-5172	277	19	patients	patient	NOUN
dpc-5172	277	20	(	(	PUNCT
dpc-5172	277	21	≥85	≥85	NOUN
dpc-5172	277	22	%	%	NOUN
dpc-5172	277	23	)	)	PUNCT
dpc-5172	277	24	.	.	PUNCT
dpc-5172	278	1	the	the	DET
dpc-5172	278	2	evaluated	evaluate	VERB
dpc-5172	278	3	histological	histological	ADJ
dpc-5172	278	4	parameters	parameter	NOUN
dpc-5172	278	5	included	include	VERB
dpc-5172	278	6	keratinocytic	keratinocytic	ADJ
dpc-5172	278	7	dysplasia	dysplasia	NOUN
dpc-5172	278	8	,	,	PUNCT
dpc-5172	278	9	melanocytic	melanocytic	ADJ
dpc-5172	278	10	dysplasia	dysplasia	NOUN
dpc-5172	278	11	,	,	PUNCT
dpc-5172	278	12	dermal	dermal	ADJ
dpc-5172	278	13	elastosis	elastosis	NOUN
dpc-5172	278	14	,	,	PUNCT
dpc-5172	278	15	and	and	CCONJ
dpc-5172	278	16	the	the	DET
dpc-5172	278	17	stratum	stratum	NOUN
dpc-5172	278	18	corneum	corneum	NOUN
dpc-5172	278	19	.	.	PUNCT
dpc-5172	279	1	the	the	DET
dpc-5172	279	2	findings	finding	NOUN
dpc-5172	279	3	demonstrated	demonstrate	VERB
dpc-5172	279	4	that	that	SCONJ
dpc-5172	279	5	topical	topical	ADJ
dpc-5172	279	6	tretinoin	tretinoin	NOUN
dpc-5172	279	7	is	be	AUX
dpc-5172	279	8	safe	safe	ADJ
dpc-5172	279	9	for	for	ADP
dpc-5172	279	10	longterm	longterm	ADJ
dpc-5172	279	11	use	use	NOUN
dpc-5172	279	12	of	of	ADP
dpc-5172	279	13	up	up	ADP
dpc-5172	279	14	to	to	PART
dpc-5172	279	15	two	two	NUM
dpc-5172	279	16	years	year	NOUN
dpc-5172	279	17	and	and	CCONJ
dpc-5172	279	18	does	do	AUX
dpc-5172	279	19	not	not	PART
dpc-5172	279	20	induce	induce	VERB
dpc-5172	279	21	cellular	cellular	ADJ
dpc-5172	279	22	atypia	atypia	NOUN
dpc-5172	279	23	within	within	ADP
dpc-5172	279	24	that	that	DET
dpc-5172	279	25	timeframe	timeframe	NOUN
dpc-5172	279	26	.	.	PUNCT
dpc-5172	280	1	in	in	ADP
dpc-5172	280	2	addition	addition	NOUN
dpc-5172	280	3	to	to	ADP
dpc-5172	280	4	retinoids	retinoid	NOUN
dpc-5172	280	5	,	,	PUNCT
dpc-5172	280	6	agents	agent	NOUN
dpc-5172	280	7	such	such	ADJ
dpc-5172	280	8	as	as	ADP
dpc-5172	280	9	peptides	peptide	NOUN
dpc-5172	280	10	,	,	PUNCT
dpc-5172	280	11	antioxidants	antioxidant	NOUN
dpc-5172	280	12	,	,	PUNCT
dpc-5172	280	13	and	and	CCONJ
dpc-5172	280	14	growth	growth	NOUN
dpc-5172	280	15	factors	factor	NOUN
dpc-5172	280	16	have	have	AUX
dpc-5172	280	17	garnered	garner	VERB
dpc-5172	280	18	interest	interest	NOUN
dpc-5172	280	19	for	for	ADP
dpc-5172	280	20	their	their	PRON
dpc-5172	280	21	anti	anti	ADJ
dpc-5172	280	22	-	-	ADJ
dpc-5172	280	23	aging	aging	ADJ
dpc-5172	280	24	properties	property	NOUN
dpc-5172	280	25	.	.	PUNCT
dpc-5172	281	1	peptides	peptide	NOUN
dpc-5172	281	2	and	and	CCONJ
dpc-5172	281	3	growth	growth	NOUN
dpc-5172	281	4	factors	factor	NOUN
dpc-5172	281	5	,	,	PUNCT
dpc-5172	281	6	in	in	ADP
dpc-5172	281	7	particular	particular	ADJ
dpc-5172	281	8	,	,	PUNCT
dpc-5172	281	9	have	have	AUX
dpc-5172	281	10	demonstrated	demonstrate	VERB
dpc-5172	281	11	an	an	DET
dpc-5172	281	12	ability	ability	NOUN
dpc-5172	281	13	to	to	PART
dpc-5172	281	14	stimulate	stimulate	VERB
dpc-5172	281	15	collagen	collagen	NOUN
dpc-5172	281	16	production	production	NOUN
dpc-5172	281	17	and	and	CCONJ
dpc-5172	281	18	improve	improve	VERB
dpc-5172	281	19	photodamaged	photodamage	VERB
dpc-5172	281	20	skin	skin	NOUN
dpc-5172	281	21	with	with	ADP
dpc-5172	281	22	minimal	minimal	ADJ
dpc-5172	281	23	adverse	adverse	ADJ
dpc-5172	281	24	effects	effect	NOUN
dpc-5172	281	25	[	[	X
dpc-5172	281	26	9,10,25,26	9,10,25,26	NOUN
dpc-5172	281	27	]	]	X
dpc-5172	281	28	.	.	PUNCT
dpc-5172	282	1	however	however	ADV
dpc-5172	282	2	,	,	PUNCT
dpc-5172	282	3	many	many	ADJ
dpc-5172	282	4	of	of	ADP
dpc-5172	282	5	the	the	DET
dpc-5172	282	6	studies	study	NOUN
dpc-5172	282	7	that	that	PRON
dpc-5172	282	8	support	support	VERB
dpc-5172	282	9	the	the	DET
dpc-5172	282	10	use	use	NOUN
dpc-5172	282	11	of	of	ADP
dpc-5172	282	12	these	these	DET
dpc-5172	282	13	treatments	treatment	NOUN
dpc-5172	282	14	are	be	AUX
dpc-5172	282	15	review	review	NOUN
dpc-5172	282	16	|	|	ADV
dpc-5172	282	17	dermatol	dermatol	ADJ
dpc-5172	282	18	pract	pract	NOUN
dpc-5172	282	19	concept	concept	NOUN
dpc-5172	282	20	.	.	PUNCT
dpc-5172	283	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	283	2	9	9	NUM
dpc-5172	283	3	references	reference	NOUN
dpc-5172	283	4	1	1	NUM
dpc-5172	283	5	.	.	PUNCT
dpc-5172	284	1	weiss	weiss	PROPN
dpc-5172	284	2	js	js	PROPN
dpc-5172	284	3	,	,	PUNCT
dpc-5172	284	4	ellis	ellis	PROPN
dpc-5172	284	5	cn	cn	PROPN
dpc-5172	284	6	,	,	PUNCT
dpc-5172	284	7	headington	headington	PROPN
dpc-5172	284	8	jt	jt	PROPN
dpc-5172	284	9	,	,	PUNCT
dpc-5172	284	10	tincoff	tincoff	PROPN
dpc-5172	284	11	t	t	PROPN
dpc-5172	284	12	,	,	PUNCT
dpc-5172	284	13	hamilton	hamilton	PROPN
dpc-5172	284	14	ta	ta	PROPN
dpc-5172	284	15	,	,	PUNCT
dpc-5172	284	16	voorhees	voorhees	PROPN
dpc-5172	284	17	jj	jj	PROPN
dpc-5172	284	18	.	.	PROPN
dpc-5172	284	19	topical	topical	ADJ
dpc-5172	284	20	tretinoin	tretinoin	PROPN
dpc-5172	284	21	improves	improve	VERB
dpc-5172	284	22	photoaged	photoage	VERB
dpc-5172	284	23	skin	skin	NOUN
dpc-5172	284	24	.	.	PUNCT
dpc-5172	285	1	a	a	DET
dpc-5172	285	2	double	double	ADJ
dpc-5172	285	3	-	-	PUNCT
dpc-5172	285	4	blind	blind	ADJ
dpc-5172	285	5	vehicle	vehicle	NOUN
dpc-5172	285	6	-	-	PUNCT
dpc-5172	285	7	controlled	control	VERB
dpc-5172	285	8	study	study	NOUN
dpc-5172	285	9	.	.	PUNCT
dpc-5172	286	1	jama	jama	PROPN
dpc-5172	286	2	.	.	PUNCT
dpc-5172	287	1	1988;259(4):527	1988;259(4):527	NUM
dpc-5172	287	2	-	-	SYM
dpc-5172	287	3	532	532	NUM
dpc-5172	287	4	.	.	PUNCT
dpc-5172	288	1	pmid	pmid	NOUN
dpc-5172	288	2	:	:	PUNCT
dpc-5172	288	3	3336176	3336176	NUM
dpc-5172	288	4	.	.	PUNCT
dpc-5172	289	1	2	2	X
dpc-5172	289	2	.	.	X
dpc-5172	289	3	nyirady	nyirady	PROPN
dpc-5172	289	4	j	j	PROPN
dpc-5172	289	5	,	,	PUNCT
dpc-5172	289	6	bergfeld	bergfeld	NOUN
dpc-5172	289	7	w	w	PROPN
dpc-5172	289	8	,	,	PUNCT
dpc-5172	289	9	ellis	ellis	PROPN
dpc-5172	289	10	c	c	PROPN
dpc-5172	289	11	,	,	PUNCT
dpc-5172	289	12	et	et	PROPN
dpc-5172	289	13	al	al	PROPN
dpc-5172	289	14	.	.	PROPN
dpc-5172	290	1	tretinoin	tretinoin	PROPN
dpc-5172	290	2	cream	cream	PROPN
dpc-5172	290	3	0.02	0.02	NUM
dpc-5172	290	4	%	%	NOUN
dpc-5172	290	5	for	for	ADP
dpc-5172	290	6	the	the	DET
dpc-5172	290	7	treatment	treatment	NOUN
dpc-5172	290	8	of	of	ADP
dpc-5172	290	9	photodamaged	photodamage	VERB
dpc-5172	290	10	facial	facial	ADJ
dpc-5172	290	11	skin	skin	NOUN
dpc-5172	290	12	:	:	PUNCT
dpc-5172	290	13	a	a	DET
dpc-5172	290	14	review	review	NOUN
dpc-5172	290	15	of	of	ADP
dpc-5172	290	16	2	2	NUM
dpc-5172	290	17	double	double	ADJ
dpc-5172	290	18	-	-	PUNCT
dpc-5172	290	19	blind	blind	ADJ
dpc-5172	290	20	clinical	clinical	ADJ
dpc-5172	290	21	studies	study	NOUN
dpc-5172	290	22	.	.	PUNCT
dpc-5172	291	1	cutis	cutis	NOUN
dpc-5172	291	2	.	.	PUNCT
dpc-5172	292	1	2001;68(2):135	2001;68(2):135	NUM
dpc-5172	292	2	-	-	SYM
dpc-5172	292	3	142	142	NUM
dpc-5172	292	4	.	.	PUNCT
dpc-5172	293	1	pmid	pmid	NOUN
dpc-5172	293	2	:	:	PUNCT
dpc-5172	293	3	11534915	11534915	NUM
dpc-5172	293	4	.	.	PUNCT
dpc-5172	294	1	3	3	X
dpc-5172	294	2	.	.	X
dpc-5172	294	3	motamedi	motamedi	PROPN
dpc-5172	294	4	m	m	PROPN
dpc-5172	294	5	,	,	PUNCT
dpc-5172	294	6	chehade	chehade	VERB
dpc-5172	294	7	a	a	PRON
dpc-5172	294	8	,	,	PUNCT
dpc-5172	294	9	sanghera	sanghera	NOUN
dpc-5172	294	10	r	r	NOUN
dpc-5172	294	11	,	,	PUNCT
dpc-5172	294	12	grewal	grewal	PROPN
dpc-5172	294	13	p.	p.	NOUN
dpc-5172	295	1	a	a	DET
dpc-5172	295	2	clinician	clinician	NOUN
dpc-5172	295	3	’s	’s	PART
dpc-5172	295	4	guide	guide	NOUN
dpc-5172	295	5	to	to	ADP
dpc-5172	295	6	topical	topical	ADJ
dpc-5172	295	7	retinoids	retinoid	NOUN
dpc-5172	295	8	.	.	PUNCT
dpc-5172	296	1	j	j	PROPN
dpc-5172	296	2	cutan	cutan	PROPN
dpc-5172	296	3	med	med	ADJ
dpc-5172	296	4	surg	surg	NOUN
dpc-5172	296	5	.	.	PUNCT
dpc-5172	297	1	2022;26(1):71	2022;26(1):71	NUM
dpc-5172	297	2	-	-	SYM
dpc-5172	297	3	78	78	NUM
dpc-5172	297	4	.	.	PUNCT
dpc-5172	298	1	doi:10.1177/12034754211035091	doi:10.1177/12034754211035091	X
dpc-5172	298	2	.	.	PUNCT
dpc-5172	299	1	pmid	pmid	NOUN
dpc-5172	299	2	:	:	PUNCT
dpc-5172	299	3	34292058	34292058	NUM
dpc-5172	299	4	4	4	NUM
dpc-5172	299	5	.	.	PUNCT
dpc-5172	300	1	kang	kang	PROPN
dpc-5172	300	2	s	s	PROPN
dpc-5172	300	3	,	,	PUNCT
dpc-5172	300	4	bergfeld	bergfeld	NOUN
dpc-5172	300	5	w	w	PROPN
dpc-5172	300	6	,	,	PUNCT
dpc-5172	300	7	gottlieb	gottlieb	PROPN
dpc-5172	300	8	ab	ab	PROPN
dpc-5172	300	9	,	,	PUNCT
dpc-5172	300	10	et	et	PROPN
dpc-5172	300	11	al	al	PROPN
dpc-5172	300	12	.	.	PUNCT
dpc-5172	301	1	long	long	ADJ
dpc-5172	301	2	-	-	PUNCT
dpc-5172	301	3	term	term	NOUN
dpc-5172	301	4	efficacy	efficacy	NOUN
dpc-5172	301	5	and	and	CCONJ
dpc-5172	301	6	safety	safety	NOUN
dpc-5172	301	7	of	of	ADP
dpc-5172	301	8	tretinoin	tretinoin	PROPN
dpc-5172	301	9	emollient	emollient	NOUN
dpc-5172	301	10	cream	cream	NOUN
dpc-5172	301	11	0.05	0.05	NUM
dpc-5172	301	12	%	%	NOUN
dpc-5172	301	13	in	in	ADP
dpc-5172	301	14	the	the	DET
dpc-5172	301	15	treatment	treatment	NOUN
dpc-5172	301	16	of	of	ADP
dpc-5172	301	17	photodamaged	photodamage	VERB
dpc-5172	301	18	facial	facial	ADJ
dpc-5172	301	19	skin	skin	NOUN
dpc-5172	301	20	:	:	PUNCT
dpc-5172	301	21	a	a	DET
dpc-5172	301	22	two	two	NUM
dpc-5172	301	23	-	-	PUNCT
dpc-5172	301	24	year	year	NOUN
dpc-5172	301	25	,	,	PUNCT
dpc-5172	301	26	randomized	randomize	VERB
dpc-5172	301	27	,	,	PUNCT
dpc-5172	301	28	placebo	placebo	NOUN
dpc-5172	301	29	-	-	PUNCT
dpc-5172	301	30	controlled	control	VERB
dpc-5172	301	31	trial	trial	NOUN
dpc-5172	301	32	.	.	PUNCT
dpc-5172	301	33	  	  	SPACE
dpc-5172	302	1	am	be	AUX
dpc-5172	302	2	j	j	PROPN
dpc-5172	302	3	clin	clin	PROPN
dpc-5172	302	4	dermatol	dermatol	NOUN
dpc-5172	302	5	.	.	PUNCT
dpc-5172	303	1	2005;6(4):245	2005;6(4):245	NUM
dpc-5172	303	2	-	-	SYM
dpc-5172	303	3	253	253	NUM
dpc-5172	303	4	.	.	PUNCT
dpc-5172	304	1	doi:10.2165	doi:10.2165	PROPN
dpc-5172	304	2	/00128071	/00128071	PROPN
dpc-5172	304	3	-	-	PUNCT
dpc-5172	304	4	200506040	200506040	NUM
dpc-5172	304	5	-	-	SYM
dpc-5172	304	6	00005	00005	NUM
dpc-5172	304	7	.	.	PUNCT
dpc-5172	305	1	pmid	pmid	NOUN
dpc-5172	305	2	:	:	PUNCT
dpc-5172	305	3	16060712	16060712	NUM
dpc-5172	305	4	.	.	PUNCT
dpc-5172	306	1	5	5	X
dpc-5172	306	2	.	.	X
dpc-5172	306	3	olsen	olsen	PROPN
dpc-5172	306	4	ea	ea	PROPN
dpc-5172	306	5	,	,	PUNCT
dpc-5172	306	6	katz	katz	PROPN
dpc-5172	306	7	hi	hi	PROPN
dpc-5172	306	8	,	,	PUNCT
dpc-5172	306	9	levine	levine	PROPN
dpc-5172	306	10	n	n	CCONJ
dpc-5172	306	11	,	,	PUNCT
dpc-5172	306	12	et	et	PROPN
dpc-5172	306	13	al	al	PROPN
dpc-5172	306	14	.	.	PROPN
dpc-5172	306	15	tretinoin	tretinoin	PROPN
dpc-5172	306	16	emollient	emollient	NOUN
dpc-5172	306	17	cream	cream	NOUN
dpc-5172	306	18	:	:	PUNCT
dpc-5172	306	19	a	a	DET
dpc-5172	306	20	new	new	ADJ
dpc-5172	306	21	therapy	therapy	NOUN
dpc-5172	306	22	for	for	ADP
dpc-5172	306	23	photodamaged	photodamage	VERB
dpc-5172	306	24	skin	skin	NOUN
dpc-5172	306	25	.	.	PUNCT
dpc-5172	307	1	j	j	PROPN
dpc-5172	307	2	am	be	AUX
dpc-5172	307	3	acad	acad	ADJ
dpc-5172	307	4	dermatol	dermatol	NOUN
dpc-5172	307	5	.	.	PUNCT
dpc-5172	308	1	1992;26(2	1992;26(2	NUM
dpc-5172	308	2	pt	pt	NOUN
dpc-5172	308	3	1):215	1):215	NUM
dpc-5172	308	4	-	-	SYM
dpc-5172	308	5	224	224	NUM
dpc-5172	308	6	.	.	PUNCT
dpc-5172	308	7	doi:10.1016/0190	doi:10.1016/0190	NOUN
dpc-5172	308	8	-	-	PUNCT
dpc-5172	308	9	9622(92)70030	9622(92)70030	NUM
dpc-5172	308	10	-	-	PUNCT
dpc-5172	308	11	j.	j.	PROPN
dpc-5172	308	12	pmid	pmid	PROPN
dpc-5172	308	13	:	:	PUNCT
dpc-5172	308	14	1552056	1552056	NUM
dpc-5172	308	15	.	.	PUNCT
dpc-5172	309	1	6	6	X
dpc-5172	309	2	.	.	X
dpc-5172	309	3	andreano	andreano	PROPN
dpc-5172	309	4	jm	jm	PROPN
dpc-5172	309	5	,	,	PUNCT
dpc-5172	309	6	bergfeld	bergfeld	ADJ
dpc-5172	309	7	wf	wf	PROPN
dpc-5172	309	8	,	,	PUNCT
dpc-5172	309	9	medendorp	medendorp	PROPN
dpc-5172	310	1	sv	sv	PROPN
dpc-5172	310	2	.	.	PUNCT
dpc-5172	310	3	tretinoin	tretinoin	PROPN
dpc-5172	310	4	emollient	emollient	NOUN
dpc-5172	310	5	cream	cream	NOUN
dpc-5172	310	6	0.01	0.01	NUM
dpc-5172	310	7	%	%	NOUN
dpc-5172	310	8	for	for	ADP
dpc-5172	310	9	the	the	DET
dpc-5172	310	10	treatment	treatment	NOUN
dpc-5172	310	11	of	of	ADP
dpc-5172	310	12	photoaged	photoage	VERB
dpc-5172	310	13	skin	skin	NOUN
dpc-5172	310	14	.	.	PUNCT
dpc-5172	310	15	 	 	SPACE
dpc-5172	311	1	cleve	cleve	PROPN
dpc-5172	311	2	clin	clin	PROPN
dpc-5172	311	3	j	j	PROPN
dpc-5172	311	4	med	med	PROPN
dpc-5172	311	5	.	.	PUNCT
dpc-5172	312	1	1993;60(1):49	1993;60(1):49	NUM
dpc-5172	312	2	-	-	SYM
dpc-5172	312	3	55	55	NUM
dpc-5172	312	4	.	.	PUNCT
dpc-5172	313	1	doi:10.3949	doi:10.3949	NOUN
dpc-5172	313	2	/	/	SYM
dpc-5172	313	3	ccjm.60.1.49	ccjm.60.1.49	PROPN
dpc-5172	313	4	.	.	PUNCT
dpc-5172	314	1	pmid	pmid	NOUN
dpc-5172	314	2	:	:	PUNCT
dpc-5172	314	3	8443935	8443935	NUM
dpc-5172	314	4	.	.	PUNCT
dpc-5172	315	1	7	7	X
dpc-5172	315	2	.	.	X
dpc-5172	315	3	lowe	lowe	PROPN
dpc-5172	315	4	pm	pm	PROPN
dpc-5172	315	5	,	,	PUNCT
dpc-5172	315	6	woods	woods	PROPN
dpc-5172	315	7	j	j	PROPN
dpc-5172	315	8	,	,	PUNCT
dpc-5172	315	9	lewis	lewis	PROPN
dpc-5172	315	10	a	a	PROPN
dpc-5172	315	11	,	,	PUNCT
dpc-5172	315	12	davies	davy	NOUN
dpc-5172	315	13	a	a	PRON
dpc-5172	315	14	,	,	PUNCT
dpc-5172	315	15	cooper	cooper	PROPN
dpc-5172	315	16	aj	aj	PROPN
dpc-5172	315	17	.	.	PROPN
dpc-5172	315	18	topical	topical	ADJ
dpc-5172	315	19	tretinoin	tretinoin	PROPN
dpc-5172	315	20	improves	improve	VERB
dpc-5172	315	21	the	the	DET
dpc-5172	315	22	appearance	appearance	NOUN
dpc-5172	315	23	of	of	ADP
dpc-5172	315	24	photo	photo	NOUN
dpc-5172	315	25	damaged	damage	VERB
dpc-5172	315	26	skin	skin	NOUN
dpc-5172	315	27	.	.	PUNCT
dpc-5172	315	28	 	 	SPACE
dpc-5172	316	1	australas	australa	VERB
dpc-5172	316	2	j	j	PROPN
dpc-5172	316	3	dermatol	dermatol	NOUN
dpc-5172	316	4	.	.	PUNCT
dpc-5172	317	1	1994;35(1):1	1994;35(1):1	NUM
dpc-5172	317	2	-	-	SYM
dpc-5172	317	3	9	9	NUM
dpc-5172	317	4	.	.	PUNCT
dpc-5172	317	5	doi:10.1111	doi:10.1111	PROPN
dpc-5172	317	6	/	/	SYM
dpc-5172	317	7	j.1440	j.1440	PROPN
dpc-5172	317	8	-	-	PUNCT
dpc-5172	317	9	0960.1994	0960.1994	ADJ
dpc-5172	317	10	.tb01790.x	.tb01790.x	PUNCT
dpc-5172	317	11	.	.	PUNCT
dpc-5172	318	1	pmid	pmid	NOUN
dpc-5172	318	2	:	:	PUNCT
dpc-5172	318	3	7998893	7998893	NUM
dpc-5172	318	4	.	.	PUNCT
dpc-5172	319	1	8	8	X
dpc-5172	319	2	.	.	X
dpc-5172	320	1	weiss	weiss	PROPN
dpc-5172	320	2	js	js	PROPN
dpc-5172	320	3	,	,	PUNCT
dpc-5172	320	4	shavin	shavin	NOUN
dpc-5172	320	5	js	js	PROPN
dpc-5172	320	6	,	,	PUNCT
dpc-5172	320	7	nighland	nighland	PROPN
dpc-5172	320	8	m	m	PROPN
dpc-5172	320	9	,	,	PUNCT
dpc-5172	320	10	grossman	grossman	PROPN
dpc-5172	320	11	r.	r.	PROPN
dpc-5172	320	12	tretinoin	tretinoin	PROPN
dpc-5172	320	13	microsphere	microsphere	PROPN
dpc-5172	320	14	gel	gel	NOUN
dpc-5172	320	15	0.1	0.1	NUM
dpc-5172	320	16	%	%	NOUN
dpc-5172	320	17	for	for	ADP
dpc-5172	320	18	photodamaged	photodamage	VERB
dpc-5172	320	19	facial	facial	ADJ
dpc-5172	320	20	skin	skin	NOUN
dpc-5172	320	21	:	:	PUNCT
dpc-5172	320	22	a	a	DET
dpc-5172	320	23	placebo	placebo	NOUN
dpc-5172	320	24	controlled	control	VERB
dpc-5172	320	25	trial	trial	NOUN
dpc-5172	320	26	.	.	PUNCT
dpc-5172	320	27	 	 	SPACE
dpc-5172	320	28	cutis	cutis	NOUN
dpc-5172	320	29	.	.	PUNCT
dpc-5172	321	1	2006;78(6):426	2006;78(6):426	NUM
dpc-5172	321	2	-	-	SYM
dpc-5172	321	3	432	432	NUM
dpc-5172	321	4	.	.	PUNCT
dpc-5172	322	1	pmid	pmid	NOUN
dpc-5172	322	2	:	:	PUNCT
dpc-5172	322	3	17243432	17243432	NUM
dpc-5172	322	4	.	.	PUNCT
dpc-5172	323	1	9	9	X
dpc-5172	323	2	.	.	X
dpc-5172	323	3	lau	lau	PROPN
dpc-5172	323	4	m	m	PROPN
dpc-5172	323	5	,	,	PUNCT
dpc-5172	323	6	mineroff	mineroff	PROPN
dpc-5172	323	7	gollogly	gollogly	PROPN
dpc-5172	323	8	j	j	PROPN
dpc-5172	323	9	,	,	PUNCT
dpc-5172	323	10	wang	wang	PROPN
dpc-5172	323	11	jy	jy	PROPN
dpc-5172	323	12	,	,	PUNCT
dpc-5172	323	13	jagdeo	jagdeo	PROPN
dpc-5172	323	14	j.	j.	PROPN
dpc-5172	323	15	cosmeceuticals	cosmeceuticals	PROPN
dpc-5172	323	16	for	for	ADP
dpc-5172	323	17	antiaging	antiage	VERB
dpc-5172	323	18	:	:	PUNCT
dpc-5172	323	19	a	a	DET
dpc-5172	323	20	systematic	systematic	ADJ
dpc-5172	323	21	review	review	NOUN
dpc-5172	323	22	of	of	ADP
dpc-5172	323	23	safety	safety	NOUN
dpc-5172	323	24	and	and	CCONJ
dpc-5172	323	25	efficacy	efficacy	NOUN
dpc-5172	323	26	.	.	PUNCT
dpc-5172	323	27	  	  	SPACE
dpc-5172	323	28	arch	arch	ADJ
dpc-5172	323	29	dermatol	dermatol	NOUN
dpc-5172	323	30	res	re	NOUN
dpc-5172	323	31	.	.	PUNCT
dpc-5172	324	1	2024;316(5):173	2024;316(5):173	NOUN
dpc-5172	324	2	.	.	PUNCT
dpc-5172	325	1	published	publish	VERB
dpc-5172	325	2	2024	2024	NUM
dpc-5172	325	3	may	may	AUX
dpc-5172	325	4	17	17	NUM
dpc-5172	325	5	.	.	PUNCT
dpc-5172	326	1	doi:10.1007	doi:10.1007	VERB
dpc-5172	326	2	/	/	SYM
dpc-5172	326	3	s00403	s00403	NOUN
dpc-5172	326	4	-	-	PUNCT
dpc-5172	326	5	024	024	NUM
dpc-5172	326	6	-	-	PUNCT
dpc-5172	326	7	02908	02908	NUM
dpc-5172	326	8	-	-	SYM
dpc-5172	326	9	2	2	NUM
dpc-5172	326	10	.	.	PUNCT
dpc-5172	326	11	pmid	pmid	NOUN
dpc-5172	326	12	:	:	PUNCT
dpc-5172	326	13	38758222	38758222	NUM
dpc-5172	326	14	.	.	PUNCT
dpc-5172	327	1	despite	despite	SCONJ
dpc-5172	327	2	these	these	DET
dpc-5172	327	3	limitations	limitation	NOUN
dpc-5172	327	4	,	,	PUNCT
dpc-5172	327	5	our	our	PRON
dpc-5172	327	6	findings	finding	NOUN
dpc-5172	327	7	indicate	indicate	VERB
dpc-5172	327	8	that	that	SCONJ
dpc-5172	327	9	tretinoin	tretinoin	NOUN
dpc-5172	327	10	,	,	PUNCT
dpc-5172	327	11	across	across	ADP
dpc-5172	327	12	various	various	ADJ
dpc-5172	327	13	dosages	dosage	NOUN
dpc-5172	327	14	and	and	CCONJ
dpc-5172	327	15	treatment	treatment	NOUN
dpc-5172	327	16	durations	duration	NOUN
dpc-5172	327	17	,	,	PUNCT
dpc-5172	327	18	significantly	significantly	ADV
dpc-5172	327	19	improves	improve	VERB
dpc-5172	327	20	fine	fine	ADJ
dpc-5172	327	21	and	and	CCONJ
dpc-5172	327	22	coarse	coarse	ADJ
dpc-5172	327	23	wrinkles	wrinkle	NOUN
dpc-5172	327	24	on	on	ADP
dpc-5172	327	25	photodamaged	photodamage	VERB
dpc-5172	327	26	facial	facial	ADJ
dpc-5172	327	27	skin	skin	NOUN
dpc-5172	327	28	.	.	PUNCT
dpc-5172	328	1	findings	finding	NOUN
dpc-5172	328	2	of	of	ADP
dpc-5172	328	3	patient	patient	ADJ
dpc-5172	328	4	satisfaction	satisfaction	NOUN
dpc-5172	328	5	,	,	PUNCT
dpc-5172	328	6	as	as	SCONJ
dpc-5172	328	7	reflected	reflect	VERB
dpc-5172	328	8	in	in	ADP
dpc-5172	328	9	subjective	subjective	ADJ
dpc-5172	328	10	assessments	assessment	NOUN
dpc-5172	328	11	,	,	PUNCT
dpc-5172	328	12	further	far	ADV
dpc-5172	328	13	support	support	VERB
dpc-5172	328	14	the	the	DET
dpc-5172	328	15	clinical	clinical	ADJ
dpc-5172	328	16	value	value	NOUN
dpc-5172	328	17	of	of	ADP
dpc-5172	328	18	tretinoin	tretinoin	PROPN
dpc-5172	328	19	treatment	treatment	NOUN
dpc-5172	328	20	.	.	PUNCT
dpc-5172	329	1	however	however	ADV
dpc-5172	329	2	,	,	PUNCT
dpc-5172	329	3	such	such	ADJ
dpc-5172	329	4	treatment	treatment	NOUN
dpc-5172	329	5	’s	’s	PART
dpc-5172	329	6	association	association	NOUN
dpc-5172	329	7	with	with	ADP
dpc-5172	329	8	skin	skin	NOUN
dpc-5172	329	9	irritation	irritation	NOUN
dpc-5172	329	10	highlights	highlight	VERB
dpc-5172	329	11	a	a	DET
dpc-5172	329	12	need	need	NOUN
dpc-5172	329	13	for	for	ADP
dpc-5172	329	14	continued	continued	ADJ
dpc-5172	329	15	research	research	NOUN
dpc-5172	329	16	to	to	PART
dpc-5172	329	17	determine	determine	VERB
dpc-5172	329	18	optimal	optimal	ADJ
dpc-5172	329	19	dosing	dosing	ADJ
dpc-5172	329	20	strategies	strategy	NOUN
dpc-5172	329	21	and	and	CCONJ
dpc-5172	329	22	to	to	PART
dpc-5172	329	23	develop	develop	VERB
dpc-5172	329	24	approaches	approach	NOUN
dpc-5172	329	25	to	to	ADP
dpc-5172	329	26	minimizing	minimize	VERB
dpc-5172	329	27	adverse	adverse	ADJ
dpc-5172	329	28	reactions	reaction	NOUN
dpc-5172	329	29	,	,	PUNCT
dpc-5172	329	30	which	which	PRON
dpc-5172	329	31	can	can	AUX
dpc-5172	329	32	improve	improve	VERB
dpc-5172	329	33	the	the	DET
dpc-5172	329	34	efficacy	efficacy	NOUN
dpc-5172	329	35	and	and	CCONJ
dpc-5172	329	36	safety	safety	NOUN
dpc-5172	329	37	of	of	ADP
dpc-5172	329	38	treatment	treatment	NOUN
dpc-5172	329	39	.	.	PUNCT
dpc-5172	330	1	conclusion	conclusion	NOUN
dpc-5172	330	2	tretinoin	tretinoin	PROPN
dpc-5172	330	3	treatment	treatment	NOUN
dpc-5172	330	4	has	have	AUX
dpc-5172	330	5	been	be	AUX
dpc-5172	330	6	demonstrated	demonstrate	VERB
dpc-5172	330	7	to	to	PART
dpc-5172	330	8	significantly	significantly	ADV
dpc-5172	330	9	improve	improve	VERB
dpc-5172	330	10	facial	facial	ADJ
dpc-5172	330	11	wrinkling	wrinkling	NOUN
dpc-5172	330	12	caused	cause	VERB
dpc-5172	330	13	by	by	ADP
dpc-5172	330	14	photodamage	photodamage	NOUN
dpc-5172	330	15	,	,	PUNCT
dpc-5172	330	16	including	include	VERB
dpc-5172	330	17	both	both	CCONJ
dpc-5172	330	18	fine	fine	ADJ
dpc-5172	330	19	and	and	CCONJ
dpc-5172	330	20	coarse	coarse	ADJ
dpc-5172	330	21	wrinkles	wrinkle	NOUN
dpc-5172	330	22	,	,	PUNCT
dpc-5172	330	23	relative	relative	ADJ
dpc-5172	330	24	to	to	ADP
dpc-5172	330	25	a	a	DET
dpc-5172	330	26	vehicle	vehicle	NOUN
dpc-5172	330	27	.	.	PUNCT
dpc-5172	331	1	although	although	SCONJ
dpc-5172	331	2	some	some	DET
dpc-5172	331	3	patients	patient	NOUN
dpc-5172	331	4	experience	experience	VERB
dpc-5172	331	5	skin	skin	NOUN
dpc-5172	331	6	irritation	irritation	NOUN
dpc-5172	331	7	in	in	ADP
dpc-5172	331	8	response	response	NOUN
dpc-5172	331	9	to	to	ADP
dpc-5172	331	10	treatment	treatment	NOUN
dpc-5172	331	11	,	,	PUNCT
dpc-5172	331	12	overall	overall	ADJ
dpc-5172	331	13	satisfaction	satisfaction	NOUN
dpc-5172	331	14	with	with	ADP
dpc-5172	331	15	the	the	DET
dpc-5172	331	16	improvements	improvement	NOUN
dpc-5172	331	17	in	in	ADP
dpc-5172	331	18	photoaging	photoage	VERB
dpc-5172	331	19	was	be	AUX
dpc-5172	331	20	frequently	frequently	ADV
dpc-5172	331	21	reported	report	VERB
dpc-5172	331	22	following	follow	VERB
dpc-5172	331	23	tretinoin	tretinoin	NOUN
dpc-5172	331	24	therapy	therapy	NOUN
dpc-5172	331	25	.	.	PUNCT
dpc-5172	332	1	these	these	DET
dpc-5172	332	2	findings	finding	NOUN
dpc-5172	332	3	underscore	underscore	VERB
dpc-5172	332	4	the	the	DET
dpc-5172	332	5	therapeutic	therapeutic	ADJ
dpc-5172	332	6	value	value	NOUN
dpc-5172	332	7	of	of	ADP
dpc-5172	332	8	topical	topical	ADJ
dpc-5172	332	9	tretinoin	tretinoin	NOUN
dpc-5172	332	10	in	in	ADP
dpc-5172	332	11	addressing	address	VERB
dpc-5172	332	12	visible	visible	ADJ
dpc-5172	332	13	signs	sign	NOUN
dpc-5172	332	14	of	of	ADP
dpc-5172	332	15	photoaging	photoage	VERB
dpc-5172	332	16	.	.	PUNCT
dpc-5172	333	1	however	however	ADV
dpc-5172	333	2	,	,	PUNCT
dpc-5172	333	3	because	because	SCONJ
dpc-5172	333	4	of	of	ADP
dpc-5172	333	5	the	the	DET
dpc-5172	333	6	potential	potential	NOUN
dpc-5172	333	7	for	for	ADP
dpc-5172	333	8	irritation	irritation	NOUN
dpc-5172	333	9	and	and	CCONJ
dpc-5172	333	10	the	the	DET
dpc-5172	333	11	variability	variability	NOUN
dpc-5172	333	12	in	in	ADP
dpc-5172	333	13	individual	individual	ADJ
dpc-5172	333	14	responses	response	NOUN
dpc-5172	333	15	,	,	PUNCT
dpc-5172	333	16	additional	additional	ADJ
dpc-5172	333	17	research	research	NOUN
dpc-5172	333	18	should	should	AUX
dpc-5172	333	19	be	be	AUX
dpc-5172	333	20	conducted	conduct	VERB
dpc-5172	333	21	to	to	PART
dpc-5172	333	22	develop	develop	VERB
dpc-5172	333	23	safer	safe	ADJ
dpc-5172	333	24	and	and	CCONJ
dpc-5172	333	25	more	more	ADV
dpc-5172	333	26	effective	effective	ADJ
dpc-5172	333	27	tretinoin	tretinoin	NOUN
dpc-5172	333	28	formulations	formulation	NOUN
dpc-5172	333	29	that	that	PRON
dpc-5172	333	30	better	well	ADV
dpc-5172	333	31	accommodate	accommodate	ADJ
dpc-5172	333	32	patient	patient	NOUN
dpc-5172	333	33	needs	need	NOUN
dpc-5172	333	34	.	.	PUNCT
dpc-5172	334	1	long	long	ADJ
dpc-5172	334	2	-	-	PUNCT
dpc-5172	334	3	term	term	NOUN
dpc-5172	334	4	follow	follow	NOUN
dpc-5172	334	5	-	-	PUNCT
dpc-5172	334	6	up	up	ADP
dpc-5172	334	7	studies	study	NOUN
dpc-5172	334	8	are	be	AUX
dpc-5172	334	9	also	also	ADV
dpc-5172	334	10	necessary	necessary	ADJ
dpc-5172	334	11	to	to	PART
dpc-5172	334	12	evaluate	evaluate	VERB
dpc-5172	334	13	the	the	DET
dpc-5172	334	14	durability	durability	NOUN
dpc-5172	334	15	of	of	ADP
dpc-5172	334	16	treatment	treatment	NOUN
dpc-5172	334	17	effects	effect	NOUN
dpc-5172	334	18	and	and	CCONJ
dpc-5172	334	19	to	to	PART
dpc-5172	334	20	assess	assess	VERB
dpc-5172	334	21	the	the	DET
dpc-5172	334	22	long	long	ADJ
dpc-5172	334	23	-	-	PUNCT
dpc-5172	334	24	term	term	NOUN
dpc-5172	334	25	safety	safety	NOUN
dpc-5172	334	26	of	of	ADP
dpc-5172	334	27	topical	topical	ADJ
dpc-5172	334	28	retinoids	retinoid	NOUN
dpc-5172	334	29	.	.	PUNCT
dpc-5172	335	1	additionally	additionally	ADV
dpc-5172	335	2	,	,	PUNCT
dpc-5172	335	3	such	such	ADJ
dpc-5172	335	4	studies	study	NOUN
dpc-5172	335	5	should	should	AUX
dpc-5172	335	6	investigate	investigate	VERB
dpc-5172	335	7	the	the	DET
dpc-5172	335	8	broader	broad	ADJ
dpc-5172	335	9	impact	impact	NOUN
dpc-5172	335	10	of	of	ADP
dpc-5172	335	11	tretinoin	tretinoin	NOUN
dpc-5172	335	12	on	on	ADP
dpc-5172	335	13	overall	overall	ADJ
dpc-5172	335	14	skin	skin	NOUN
dpc-5172	335	15	health	health	NOUN
dpc-5172	335	16	and	and	CCONJ
dpc-5172	335	17	provide	provide	VERB
dpc-5172	335	18	research	research	NOUN
dpc-5172	335	19	that	that	PRON
dpc-5172	335	20	contributes	contribute	VERB
dpc-5172	335	21	to	to	ADP
dpc-5172	335	22	the	the	DET
dpc-5172	335	23	development	development	NOUN
dpc-5172	335	24	of	of	ADP
dpc-5172	335	25	evidence	evidence	NOUN
dpc-5172	335	26	-	-	PUNCT
dpc-5172	335	27	based	base	VERB
dpc-5172	335	28	guidelines	guideline	NOUN
dpc-5172	335	29	for	for	ADP
dpc-5172	335	30	its	its	PRON
dpc-5172	335	31	integration	integration	NOUN
dpc-5172	335	32	into	into	ADP
dpc-5172	335	33	clinical	clinical	ADJ
dpc-5172	335	34	skin	skin	NOUN
dpc-5172	335	35	care	care	NOUN
dpc-5172	335	36	regimens	regimen	NOUN
dpc-5172	335	37	.	.	PUNCT
dpc-5172	336	1	table	table	NOUN
dpc-5172	336	2	2	2	NUM
dpc-5172	336	3	.	.	NOUN
dpc-5172	336	4	practical	practical	ADJ
dpc-5172	336	5	takeaways	takeaway	NOUN
dpc-5172	336	6	for	for	ADP
dpc-5172	336	7	clinicians	clinician	NOUN
dpc-5172	336	8	:	:	PUNCT
dpc-5172	336	9	topical	topical	ADJ
dpc-5172	336	10	tretinoin	tretinoin	NOUN
dpc-5172	336	11	use	use	NOUN
dpc-5172	336	12	.	.	PUNCT
dpc-5172	337	1	clinical	clinical	ADJ
dpc-5172	337	2	consideration	consideration	NOUN
dpc-5172	337	3	recommendation	recommendation	NOUN
dpc-5172	337	4	patient	patient	NOUN
dpc-5172	337	5	selection	selection	NOUN
dpc-5172	337	6	based	base	VERB
dpc-5172	337	7	on	on	ADP
dpc-5172	337	8	photodamage	photodamage	NOUN
dpc-5172	337	9	severity	severity	NOUN
dpc-5172	337	10	•	•	ADP
dpc-5172	337	11	select	select	ADJ
dpc-5172	337	12	patients	patient	NOUN
dpc-5172	337	13	with	with	ADP
dpc-5172	337	14	mild	mild	ADJ
dpc-5172	337	15	-	-	PUNCT
dpc-5172	337	16	to	to	ADP
dpc-5172	337	17	-	-	PUNCT
dpc-5172	337	18	moderate	moderate	ADJ
dpc-5172	337	19	photodamage	photodamage	NOUN
dpc-5172	337	20	for	for	ADP
dpc-5172	337	21	best	good	ADJ
dpc-5172	337	22	response	response	NOUN
dpc-5172	337	23	•	•	SCONJ
dpc-5172	337	24	use	use	VERB
dpc-5172	337	25	a	a	DET
dpc-5172	337	26	standardized	standardized	ADJ
dpc-5172	337	27	9	9	NUM
dpc-5172	337	28	-	-	PUNCT
dpc-5172	337	29	point	point	NOUN
dpc-5172	337	30	photodamage	photodamage	NOUN
dpc-5172	337	31	scale1	scale1	NOUN
dpc-5172	337	32	to	to	PART
dpc-5172	337	33	assess	assess	VERB
dpc-5172	337	34	severity	severity	NOUN
dpc-5172	337	35	•	•	ADP
dpc-5172	337	36	avoid	avoid	VERB
dpc-5172	337	37	initiating	initiate	VERB
dpc-5172	337	38	tretinoin	tretinoin	NOUN
dpc-5172	337	39	in	in	ADP
dpc-5172	337	40	patients	patient	NOUN
dpc-5172	337	41	with	with	ADP
dpc-5172	337	42	severe	severe	ADJ
dpc-5172	337	43	photodamage	photodamage	NOUN
dpc-5172	337	44	until	until	SCONJ
dpc-5172	337	45	skin	skin	NOUN
dpc-5172	337	46	barrier	barrier	NOUN
dpc-5172	337	47	is	be	AUX
dpc-5172	337	48	optimized	optimize	VERB
dpc-5172	337	49	initiation	initiation	NOUN
dpc-5172	337	50	in	in	ADP
dpc-5172	337	51	sensitive	sensitive	ADJ
dpc-5172	337	52	or	or	CCONJ
dpc-5172	337	53	reactive	reactive	ADJ
dpc-5172	337	54	skin	skin	NOUN
dpc-5172	337	55	•	•	NOUN
dpc-5172	337	56	start	start	VERB
dpc-5172	337	57	with	with	ADP
dpc-5172	337	58	lower	low	ADJ
dpc-5172	337	59	concentration	concentration	NOUN
dpc-5172	337	60	(	(	PUNCT
dpc-5172	337	61	e.g.	e.g.	ADV
dpc-5172	337	62	,	,	PUNCT
dpc-5172	337	63	≤0.02	≤0.02	NOUN
dpc-5172	337	64	%	%	NOUN
dpc-5172	337	65	)	)	PUNCT
dpc-5172	337	66	•	•	NUM
dpc-5172	337	67	titrate	titrate	NOUN
dpc-5172	337	68	gradually	gradually	ADV
dpc-5172	337	69	as	as	SCONJ
dpc-5172	337	70	tolerated	tolerate	VERB
dpc-5172	337	71	•	•	NUM
dpc-5172	337	72	reduce	reduce	VERB
dpc-5172	337	73	application	application	NOUN
dpc-5172	337	74	frequency	frequency	NOUN
dpc-5172	337	75	to	to	ADP
dpc-5172	337	76	every	every	DET
dpc-5172	337	77	other	other	ADJ
dpc-5172	337	78	night	night	NOUN
dpc-5172	337	79	if	if	SCONJ
dpc-5172	337	80	needed	need	VERB
dpc-5172	337	81	•	•	NOUN
dpc-5172	337	82	help	help	NOUN
dpc-5172	337	83	improve	improve	VERB
dpc-5172	337	84	adherence	adherence	NOUN
dpc-5172	337	85	and	and	CCONJ
dpc-5172	337	86	reduce	reduce	VERB
dpc-5172	337	87	discontinuation	discontinuation	NOUN
dpc-5172	337	88	due	due	ADP
dpc-5172	337	89	to	to	ADP
dpc-5172	337	90	irritation	irritation	NOUN
dpc-5172	337	91	strategies	strategy	NOUN
dpc-5172	337	92	for	for	ADP
dpc-5172	337	93	mitigating	mitigate	VERB
dpc-5172	337	94	adverse	adverse	ADJ
dpc-5172	337	95	reactions	reaction	NOUN
dpc-5172	337	96	•	•	ADV
dpc-5172	337	97	apply	apply	VERB
dpc-5172	337	98	moisturizer	moisturizer	NOUN
dpc-5172	337	99	before	before	ADP
dpc-5172	337	100	or	or	CCONJ
dpc-5172	337	101	after	after	ADP
dpc-5172	337	102	tretinoin	tretinoin	NOUN
dpc-5172	337	103	to	to	PART
dpc-5172	337	104	minimize	minimize	VERB
dpc-5172	337	105	irritation	irritation	NOUN
dpc-5172	337	106	•	•	NOUN
dpc-5172	337	107	educate	educate	VERB
dpc-5172	337	108	patients	patient	NOUN
dpc-5172	337	109	on	on	ADP
dpc-5172	337	110	adaptation	adaptation	NOUN
dpc-5172	337	111	period	period	NOUN
dpc-5172	337	112	(	(	PUNCT
dpc-5172	337	113	typically	typically	ADV
dpc-5172	337	114	2–4	2–4	NUM
dpc-5172	337	115	weeks	week	NOUN
dpc-5172	337	116	)	)	PUNCT
dpc-5172	337	117	•	•	ADP
dpc-5172	337	118	avoid	avoid	VERB
dpc-5172	337	119	harsh	harsh	ADJ
dpc-5172	337	120	skincare	skincare	NOUN
dpc-5172	337	121	products	product	NOUN
dpc-5172	337	122	(	(	PUNCT
dpc-5172	337	123	e.g.	e.g.	ADV
dpc-5172	337	124	,	,	PUNCT
dpc-5172	337	125	alcohol	alcohol	NOUN
dpc-5172	337	126	-	-	PUNCT
dpc-5172	337	127	based	base	VERB
dpc-5172	337	128	toners	toner	NOUN
dpc-5172	337	129	,	,	PUNCT
dpc-5172	337	130	exfoliants	exfoliant	NOUN
dpc-5172	337	131	)	)	PUNCT
dpc-5172	337	132	•	•	NUM
dpc-5172	337	133	use	use	VERB
dpc-5172	337	134	short	short	ADJ
dpc-5172	337	135	-	-	PUNCT
dpc-5172	337	136	term	term	NOUN
dpc-5172	337	137	topical	topical	ADJ
dpc-5172	337	138	corticosteroids	corticosteroid	NOUN
dpc-5172	337	139	for	for	ADP
dpc-5172	337	140	severe	severe	ADJ
dpc-5172	337	141	irritation	irritation	NOUN
dpc-5172	337	142	to	to	PART
dpc-5172	337	143	control	control	VERB
dpc-5172	337	144	inflammation	inflammation	NOUN
dpc-5172	337	145	without	without	ADP
dpc-5172	337	146	reducing	reduce	VERB
dpc-5172	337	147	efficacy	efficacy	NOUN
dpc-5172	337	148	1	1	NUM
dpc-5172	337	149	please	please	INTJ
dpc-5172	337	150	refer	refer	VERB
dpc-5172	337	151	to	to	ADP
dpc-5172	337	152	:	:	PUNCT
dpc-5172	337	153	c.e	c.e	PROPN
dpc-5172	337	154	.	.	PROPN
dpc-5172	337	155	griffiths	griffiths	PROPN
dpc-5172	337	156	,	,	PUNCT
dpc-5172	337	157	t.s	t.s	PROPN
dpc-5172	337	158	.	.	PROPN
dpc-5172	337	159	wang	wang	PROPN
dpc-5172	337	160	,	,	PUNCT
dpc-5172	337	161	t.a	t.a	PROPN
dpc-5172	337	162	.	.	PROPN
dpc-5172	337	163	hamilton	hamilton	PROPN
dpc-5172	337	164	,	,	PUNCT
dpc-5172	337	165	j.j	j.j	PROPN
dpc-5172	337	166	.	.	PROPN
dpc-5172	337	167	voorhees	voorhees	PROPN
dpc-5172	337	168	,	,	PUNCT
dpc-5172	337	169	c.n	c.n	PROPN
dpc-5172	337	170	.	.	PROPN
dpc-5172	337	171	ellis	ellis	PROPN
dpc-5172	337	172	,	,	PUNCT
dpc-5172	337	173	a	a	DET
dpc-5172	337	174	photonumeric	photonumeric	ADJ
dpc-5172	337	175	scale	scale	NOUN
dpc-5172	337	176	for	for	ADP
dpc-5172	337	177	the	the	DET
dpc-5172	337	178	assessment	assessment	NOUN
dpc-5172	337	179	of	of	ADP
dpc-5172	337	180	cutaneous	cutaneous	ADJ
dpc-5172	337	181	photodamage	photodamage	NOUN
dpc-5172	337	182	,	,	PUNCT
dpc-5172	337	183	arch	arch	ADJ
dpc-5172	337	184	dermatol	dermatol	NOUN
dpc-5172	337	185	,	,	PUNCT
dpc-5172	337	186	128	128	NUM
dpc-5172	337	187	(	(	PUNCT
dpc-5172	337	188	1992	1992	NUM
dpc-5172	337	189	)	)	PUNCT
dpc-5172	337	190	347	347	NUM
dpc-5172	337	191	-	-	SYM
dpc-5172	337	192	351	351	NUM
dpc-5172	337	193	.	.	PUNCT
dpc-5172	338	1	pmid	pmid	NOUN
dpc-5172	338	2	:	:	PUNCT
dpc-5172	338	3	1550366	1550366	NUM
dpc-5172	338	4	.	.	PUNCT
dpc-5172	339	1	10	10	NUM
dpc-5172	339	2	review	review	NOUN
dpc-5172	339	3	|	|	ADV
dpc-5172	339	4	dermatol	dermatol	ADJ
dpc-5172	339	5	pract	pract	NOUN
dpc-5172	339	6	concept	concept	NOUN
dpc-5172	339	7	.	.	PUNCT
dpc-5172	340	1	2025;15(4):5172	2025;15(4):5172	PROPN
dpc-5172	340	2	19	19	NUM
dpc-5172	340	3	.	.	PUNCT
dpc-5172	340	4	weinstein	weinstein	PROPN
dpc-5172	340	5	gd	gd	PROPN
dpc-5172	340	6	,	,	PUNCT
dpc-5172	340	7	nigra	nigra	PROPN
dpc-5172	340	8	tp	tp	PROPN
dpc-5172	340	9	,	,	PUNCT
dpc-5172	340	10	pochi	pochi	PROPN
dpc-5172	340	11	pe	pe	PROPN
dpc-5172	340	12	,	,	PUNCT
dpc-5172	340	13	et	et	PROPN
dpc-5172	340	14	al	al	PROPN
dpc-5172	340	15	.	.	PROPN
dpc-5172	340	16	topical	topical	ADJ
dpc-5172	340	17	tretinoin	tretinoin	NOUN
dpc-5172	340	18	for	for	ADP
dpc-5172	340	19	treatment	treatment	NOUN
dpc-5172	340	20	of	of	ADP
dpc-5172	340	21	photodamaged	photodamage	VERB
dpc-5172	340	22	skin	skin	NOUN
dpc-5172	340	23	.	.	PUNCT
dpc-5172	341	1	a	a	DET
dpc-5172	341	2	multicenter	multicenter	ADJ
dpc-5172	341	3	study	study	NOUN
dpc-5172	341	4	.	.	PUNCT
dpc-5172	341	5	 	 	SPACE
dpc-5172	341	6	arch	arch	ADJ
dpc-5172	341	7	dermatol	dermatol	NOUN
dpc-5172	341	8	.	.	PUNCT
dpc-5172	342	1	1991;127(5):659	1991;127(5):659	NUM
dpc-5172	342	2	-	-	SYM
dpc-5172	342	3	665	665	NUM
dpc-5172	342	4	.	.	PUNCT
dpc-5172	343	1	pmid	pmid	NOUN
dpc-5172	343	2	:	:	PUNCT
dpc-5172	343	3	2024983	2024983	NUM
dpc-5172	343	4	.	.	PUNCT
dpc-5172	344	1	20	20	NUM
dpc-5172	344	2	.	.	PUNCT
dpc-5172	345	1	sterne	sterne	PROPN
dpc-5172	345	2	jac	jac	PROPN
dpc-5172	345	3	,	,	PUNCT
dpc-5172	345	4	savović	savović	PROPN
dpc-5172	345	5	j	j	PROPN
dpc-5172	345	6	,	,	PUNCT
dpc-5172	345	7	page	page	NOUN
dpc-5172	345	8	mj	mj	PROPN
dpc-5172	345	9	,	,	PUNCT
dpc-5172	345	10	et	et	PROPN
dpc-5172	345	11	al	al	PROPN
dpc-5172	345	12	.	.	PROPN
dpc-5172	345	13	rob	rob	PROPN
dpc-5172	346	1	2	2	NUM
dpc-5172	346	2	:	:	PUNCT
dpc-5172	346	3	a	a	DET
dpc-5172	346	4	revised	revise	VERB
dpc-5172	346	5	tool	tool	NOUN
dpc-5172	346	6	for	for	ADP
dpc-5172	346	7	assessing	assess	VERB
dpc-5172	346	8	risk	risk	NOUN
dpc-5172	346	9	of	of	ADP
dpc-5172	346	10	bias	bias	NOUN
dpc-5172	346	11	in	in	ADP
dpc-5172	346	12	randomised	randomised	ADJ
dpc-5172	346	13	trials	trial	NOUN
dpc-5172	346	14	.	.	PUNCT
dpc-5172	346	15	 	 	SPACE
dpc-5172	347	1	bmj	bmj	PROPN
dpc-5172	347	2	.	.	PUNCT
dpc-5172	348	1	2019;366	2019;366	NUM
dpc-5172	348	2	:	:	PUNCT
dpc-5172	348	3	l4898	l4898	PROPN
dpc-5172	348	4	.	.	PROPN
dpc-5172	349	1	published	publish	VERB
dpc-5172	349	2	2019	2019	NUM
dpc-5172	349	3	aug	aug	PROPN
dpc-5172	349	4	28	28	NUM
dpc-5172	349	5	.	.	PUNCT
dpc-5172	350	1	doi:10.1136	doi:10.1136	NOUN
dpc-5172	350	2	/	/	SYM
dpc-5172	350	3	bmj.l4898	bmj.l4898	PROPN
dpc-5172	350	4	.	.	PUNCT
dpc-5172	351	1	pmid	pmid	NOUN
dpc-5172	351	2	:	:	PUNCT
dpc-5172	351	3	31462531	31462531	NUM
dpc-5172	351	4	.	.	PUNCT
dpc-5172	352	1	21	21	NUM
dpc-5172	352	2	.	.	X
dpc-5172	352	3	fisher	fisher	PROPN
dpc-5172	352	4	gj	gj	PROPN
dpc-5172	352	5	,	,	PUNCT
dpc-5172	352	6	voorhees	voorhees	PROPN
dpc-5172	352	7	jj	jj	PROPN
dpc-5172	352	8	.	.	PROPN
dpc-5172	352	9	molecular	molecular	ADJ
dpc-5172	352	10	mechanisms	mechanism	NOUN
dpc-5172	352	11	of	of	ADP
dpc-5172	352	12	retinoid	retinoid	PROPN
dpc-5172	352	13	actions	action	NOUN
dpc-5172	352	14	in	in	ADP
dpc-5172	352	15	skin	skin	NOUN
dpc-5172	352	16	.	.	PUNCT
dpc-5172	352	17	  	  	SPACE
dpc-5172	352	18	faseb	faseb	PROPN
dpc-5172	352	19	j.	j.	PROPN
dpc-5172	352	20	1996;10(9):1002	1996;10(9):1002	PROPN
dpc-5172	352	21	-	-	SYM
dpc-5172	352	22	1013	1013	NUM
dpc-5172	352	23	.	.	PUNCT
dpc-5172	353	1	doi:10.1096	doi:10.1096	NOUN
dpc-5172	353	2	/fasebj.10.9.8801161	/fasebj.10.9.8801161	PROPN
dpc-5172	353	3	.	.	PUNCT
dpc-5172	354	1	pmid	pmid	NOUN
dpc-5172	354	2	:	:	PUNCT
dpc-5172	354	3	8801161	8801161	NUM
dpc-5172	354	4	.	.	PUNCT
dpc-5172	355	1	22	22	NUM
dpc-5172	355	2	.	.	PUNCT
dpc-5172	356	1	chapellier	chapellier	PROPN
dpc-5172	356	2	b	b	PROPN
dpc-5172	356	3	,	,	PUNCT
dpc-5172	356	4	mark	mark	PROPN
dpc-5172	356	5	m	m	PROPN
dpc-5172	356	6	,	,	PUNCT
dpc-5172	356	7	messaddeq	messaddeq	PROPN
dpc-5172	356	8	n	n	CCONJ
dpc-5172	356	9	,	,	PUNCT
dpc-5172	356	10	et	et	PROPN
dpc-5172	356	11	al	al	PROPN
dpc-5172	356	12	.	.	PROPN
dpc-5172	356	13	physiological	physiological	PROPN
dpc-5172	356	14	and	and	CCONJ
dpc-5172	356	15	retinoid	retinoid	NOUN
dpc-5172	356	16	-	-	PUNCT
dpc-5172	356	17	induced	induce	VERB
dpc-5172	356	18	proliferations	proliferation	NOUN
dpc-5172	356	19	of	of	ADP
dpc-5172	356	20	epidermis	epidermis	NOUN
dpc-5172	356	21	basal	basal	NOUN
dpc-5172	356	22	keratinocytes	keratinocyte	NOUN
dpc-5172	356	23	are	be	AUX
dpc-5172	356	24	differently	differently	ADV
dpc-5172	356	25	controlled	control	VERB
dpc-5172	356	26	.	.	PUNCT
dpc-5172	356	27	  	  	SPACE
dpc-5172	357	1	embo	embo	PROPN
dpc-5172	357	2	j.	j.	PROPN
dpc-5172	357	3	2002;21(13):3402	2002;21(13):3402	PROPN
dpc-5172	357	4	-	-	PUNCT
dpc-5172	357	5	3413	3413	NUM
dpc-5172	357	6	.	.	PUNCT
dpc-5172	358	1	doi:10.1093	doi:10.1093	NOUN
dpc-5172	358	2	/	/	SYM
dpc-5172	358	3	emboj	emboj	NOUN
dpc-5172	358	4	/	/	SYM
dpc-5172	358	5	cdf331	cdf331	NOUN
dpc-5172	358	6	.	.	PUNCT
dpc-5172	359	1	pmid	pmid	NOUN
dpc-5172	359	2	:	:	PUNCT
dpc-5172	359	3	12093741	12093741	NUM
dpc-5172	359	4	.	.	PUNCT
dpc-5172	360	1	23	23	NUM
dpc-5172	360	2	.	.	PUNCT
dpc-5172	361	1	varani	varani	PROPN
dpc-5172	361	2	j	j	PROPN
dpc-5172	361	3	,	,	PUNCT
dpc-5172	361	4	zeigler	zeigler	PROPN
dpc-5172	361	5	m	m	PROPN
dpc-5172	361	6	,	,	PUNCT
dpc-5172	361	7	dame	dame	PROPN
dpc-5172	361	8	mk	mk	PROPN
dpc-5172	361	9	,	,	PUNCT
dpc-5172	361	10	et	et	PROPN
dpc-5172	361	11	al	al	PROPN
dpc-5172	361	12	.	.	PROPN
dpc-5172	361	13	heparin	heparin	NOUN
dpc-5172	361	14	-	-	PUNCT
dpc-5172	361	15	binding	bind	VERB
dpc-5172	361	16	epidermal	epidermal	ADJ
dpc-5172	361	17	-	-	PUNCT
dpc-5172	361	18	growth	growth	NOUN
dpc-5172	361	19	-	-	PUNCT
dpc-5172	361	20	factor	factor	NOUN
dpc-5172	361	21	-	-	PUNCT
dpc-5172	361	22	like	like	ADJ
dpc-5172	361	23	growth	growth	NOUN
dpc-5172	361	24	factor	factor	NOUN
dpc-5172	361	25	activation	activation	NOUN
dpc-5172	361	26	of	of	ADP
dpc-5172	361	27	keratinocyte	keratinocyte	NOUN
dpc-5172	361	28	erbb	erbb	NOUN
dpc-5172	361	29	receptors	receptor	NOUN
dpc-5172	361	30	mediates	mediate	VERB
dpc-5172	361	31	epidermal	epidermal	ADJ
dpc-5172	361	32	hyperplasia	hyperplasia	NOUN
dpc-5172	361	33	,	,	PUNCT
dpc-5172	361	34	a	a	DET
dpc-5172	361	35	prominent	prominent	ADJ
dpc-5172	361	36	side	side	NOUN
dpc-5172	361	37	-	-	PUNCT
dpc-5172	361	38	effect	effect	NOUN
dpc-5172	361	39	of	of	ADP
dpc-5172	361	40	retinoid	retinoid	NOUN
dpc-5172	361	41	therapy	therapy	NOUN
dpc-5172	361	42	.	.	PUNCT
dpc-5172	361	43	  	  	SPACE
dpc-5172	362	1	j	j	PROPN
dpc-5172	362	2	invest	invest	VERB
dpc-5172	362	3	dermatol	dermatol	NOUN
dpc-5172	362	4	.	.	PUNCT
dpc-5172	363	1	2001;117(6):1335	2001;117(6):1335	NUM
dpc-5172	363	2	-	-	SYM
dpc-5172	363	3	1341	1341	NUM
dpc-5172	363	4	.	.	PUNCT
dpc-5172	364	1	doi:10.1046	doi:10.1046	ADJ
dpc-5172	364	2	/	/	SYM
dpc-5172	364	3	j.0022	j.0022	NOUN
dpc-5172	364	4	-	-	PUNCT
dpc-5172	364	5	202x.2001	202x.2001	NOUN
dpc-5172	364	6	.01564.x	.01564.x	NOUN
dpc-5172	364	7	.	.	PUNCT
dpc-5172	365	1	pmid	pmid	NOUN
dpc-5172	365	2	:	:	PUNCT
dpc-5172	365	3	11886492	11886492	NUM
dpc-5172	365	4	.	.	PUNCT
dpc-5172	366	1	24	24	NUM
dpc-5172	366	2	.	.	PUNCT
dpc-5172	367	1	rittié	rittié	PROPN
dpc-5172	367	2	l	l	PROPN
dpc-5172	367	3	,	,	PUNCT
dpc-5172	367	4	varani	varani	PROPN
dpc-5172	367	5	j	j	PROPN
dpc-5172	367	6	,	,	PUNCT
dpc-5172	367	7	kang	kang	PROPN
dpc-5172	367	8	s	s	PROPN
dpc-5172	367	9	,	,	PUNCT
dpc-5172	367	10	voorhees	voorhees	PROPN
dpc-5172	367	11	jj	jj	PROPN
dpc-5172	367	12	,	,	PUNCT
dpc-5172	367	13	fisher	fisher	PROPN
dpc-5172	367	14	gj	gj	PROPN
dpc-5172	367	15	.	.	PUNCT
dpc-5172	368	1	retinoid	retinoid	NOUN
dpc-5172	368	2	-	-	PUNCT
dpc-5172	368	3	induced	induce	VERB
dpc-5172	368	4	epidermal	epidermal	ADJ
dpc-5172	368	5	hyperplasia	hyperplasia	NOUN
dpc-5172	368	6	is	be	AUX
dpc-5172	368	7	mediated	mediate	VERB
dpc-5172	368	8	by	by	ADP
dpc-5172	368	9	epidermal	epidermal	ADJ
dpc-5172	368	10	growth	growth	NOUN
dpc-5172	368	11	factor	factor	NOUN
dpc-5172	368	12	receptor	receptor	NOUN
dpc-5172	368	13	activation	activation	NOUN
dpc-5172	368	14	via	via	ADP
dpc-5172	368	15	specific	specific	ADJ
dpc-5172	368	16	induction	induction	NOUN
dpc-5172	368	17	of	of	ADP
dpc-5172	368	18	its	its	PRON
dpc-5172	368	19	ligands	ligand	NOUN
dpc-5172	368	20	heparin	heparin	NOUN
dpc-5172	368	21	-	-	PUNCT
dpc-5172	368	22	binding	bind	VERB
dpc-5172	368	23	egf	egf	NOUN
dpc-5172	368	24	and	and	CCONJ
dpc-5172	368	25	amphiregulin	amphiregulin	PROPN
dpc-5172	368	26	in	in	ADP
dpc-5172	368	27	human	human	ADJ
dpc-5172	368	28	skin	skin	NOUN
dpc-5172	368	29	in	in	ADP
dpc-5172	368	30	vivo	vivo	NOUN
dpc-5172	368	31	.	.	PUNCT
dpc-5172	368	32	  	  	SPACE
dpc-5172	369	1	j	j	PROPN
dpc-5172	369	2	invest	invest	VERB
dpc-5172	369	3	dermatol	dermatol	NOUN
dpc-5172	369	4	.	.	PUNCT
dpc-5172	370	1	2006;126(4):732	2006;126(4):732	NUM
dpc-5172	370	2	-	-	SYM
dpc-5172	370	3	739	739	NUM
dpc-5172	370	4	.	.	PUNCT
dpc-5172	370	5	doi:10.1038	doi:10.1038	NOUN
dpc-5172	370	6	/sj.jid.5700202	/sj.jid.5700202	PROPN
dpc-5172	370	7	.	.	PUNCT
dpc-5172	371	1	pmid	pmid	NOUN
dpc-5172	371	2	:	:	PUNCT
dpc-5172	371	3	16470170	16470170	NUM
dpc-5172	371	4	.	.	PUNCT
dpc-5172	372	1	25	25	NUM
dpc-5172	372	2	.	.	PUNCT
dpc-5172	373	1	pintea	pintea	PROPN
dpc-5172	373	2	a	a	PROPN
dpc-5172	373	3	,	,	PUNCT
dpc-5172	373	4	manea	manea	PROPN
dpc-5172	373	5	a	a	X
dpc-5172	373	6	,	,	PUNCT
dpc-5172	373	7	pintea	pintea	NOUN
dpc-5172	373	8	c	c	NOUN
dpc-5172	373	9	,	,	PUNCT
dpc-5172	373	10	et	et	PROPN
dpc-5172	373	11	al	al	PROPN
dpc-5172	373	12	.	.	PUNCT
dpc-5172	373	13	peptides	peptide	NOUN
dpc-5172	373	14	:	:	PUNCT
dpc-5172	373	15	emerging	emerge	VERB
dpc-5172	373	16	candidates	candidate	NOUN
dpc-5172	373	17	for	for	ADP
dpc-5172	373	18	the	the	DET
dpc-5172	373	19	prevention	prevention	NOUN
dpc-5172	373	20	and	and	CCONJ
dpc-5172	373	21	treatment	treatment	NOUN
dpc-5172	373	22	of	of	ADP
dpc-5172	373	23	skin	skin	NOUN
dpc-5172	373	24	senescence	senescence	NOUN
dpc-5172	373	25	:	:	PUNCT
dpc-5172	373	26	a	a	DET
dpc-5172	373	27	review	review	NOUN
dpc-5172	373	28	.	.	PUNCT
dpc-5172	373	29	  	  	SPACE
dpc-5172	373	30	biomolecules	biomolecule	NOUN
dpc-5172	373	31	.	.	PUNCT
dpc-5172	374	1	2025;15(1):88	2025;15(1):88	NUM
dpc-5172	374	2	.	.	PUNCT
dpc-5172	375	1	published	publish	VERB
dpc-5172	375	2	2025	2025	NUM
dpc-5172	375	3	jan	jan	NOUN
dpc-5172	375	4	9	9	NUM
dpc-5172	375	5	.	.	PUNCT
dpc-5172	375	6	doi:10.3390	doi:10.3390	PROPN
dpc-5172	375	7	/	/	SYM
dpc-5172	375	8	biom15010088	biom15010088	PROPN
dpc-5172	375	9	.	.	PUNCT
dpc-5172	376	1	pmid	pmid	NOUN
dpc-5172	376	2	:	:	PUNCT
dpc-5172	376	3	39858482	39858482	NUM
dpc-5172	376	4	.	.	PUNCT
dpc-5172	377	1	26	26	NUM
dpc-5172	377	2	.	.	PUNCT
dpc-5172	378	1	aldag	aldag	PROPN
dpc-5172	378	2	c	c	PROPN
dpc-5172	378	3	,	,	PUNCT
dpc-5172	378	4	nogueira	nogueira	PROPN
dpc-5172	378	5	teixeira	teixeira	PROPN
dpc-5172	378	6	d	d	PROPN
dpc-5172	378	7	,	,	PUNCT
dpc-5172	378	8	leventhal	leventhal	PROPN
dpc-5172	378	9	ps	ps	PROPN
dpc-5172	378	10	.	.	PROPN
dpc-5172	378	11	skin	skin	NOUN
dpc-5172	378	12	rejuvenation	rejuvenation	NOUN
dpc-5172	378	13	using	use	VERB
dpc-5172	378	14	cosmetic	cosmetic	ADJ
dpc-5172	378	15	products	product	NOUN
dpc-5172	378	16	containing	contain	VERB
dpc-5172	378	17	growth	growth	NOUN
dpc-5172	378	18	factors	factor	NOUN
dpc-5172	378	19	,	,	PUNCT
dpc-5172	378	20	cytokines	cytokine	NOUN
dpc-5172	378	21	,	,	PUNCT
dpc-5172	378	22	and	and	CCONJ
dpc-5172	378	23	matrikines	matrikine	NOUN
dpc-5172	378	24	:	:	PUNCT
dpc-5172	378	25	a	a	DET
dpc-5172	378	26	review	review	NOUN
dpc-5172	378	27	of	of	ADP
dpc-5172	378	28	the	the	DET
dpc-5172	378	29	literature	literature	NOUN
dpc-5172	378	30	.	.	PUNCT
dpc-5172	378	31	  	  	SPACE
dpc-5172	379	1	clin	clin	PROPN
dpc-5172	379	2	cosmet	cosmet	NOUN
dpc-5172	379	3	investig	investig	NOUN
dpc-5172	379	4	dermatol	dermatol	NOUN
dpc-5172	379	5	.	.	PUNCT
dpc-5172	380	1	2016;9:411	2016;9:411	PROPN
dpc-5172	380	2	-	-	PUNCT
dpc-5172	380	3	419	419	NUM
dpc-5172	380	4	.	.	PUNCT
dpc-5172	381	1	published	publish	VERB
dpc-5172	381	2	2016	2016	NUM
dpc-5172	381	3	nov	nov	PROPN
dpc-5172	381	4	9	9	NUM
dpc-5172	381	5	.	.	PUNCT
dpc-5172	381	6	doi:10.2147	doi:10.2147	NOUN
dpc-5172	381	7	/	/	SYM
dpc-5172	381	8	ccid.s116158	ccid.s116158	NOUN
dpc-5172	381	9	.	.	PUNCT
dpc-5172	382	1	pmid	pmid	NOUN
dpc-5172	382	2	:	:	PUNCT
dpc-5172	382	3	27877059	27877059	NUM
dpc-5172	382	4	.	.	PUNCT
dpc-5172	383	1	10	10	NUM
dpc-5172	383	2	.	.	X
dpc-5172	383	3	chan	chan	PROPN
dpc-5172	383	4	lkw	lkw	PROPN
dpc-5172	383	5	,	,	PUNCT
dpc-5172	383	6	lee	lee	PROPN
dpc-5172	383	7	kwa	kwa	PROPN
dpc-5172	383	8	,	,	PUNCT
dpc-5172	383	9	lee	lee	PROPN
dpc-5172	383	10	ch	ch	PROPN
dpc-5172	383	11	,	,	PUNCT
dpc-5172	383	12	et	et	PROPN
dpc-5172	383	13	al	al	PROPN
dpc-5172	383	14	.	.	PROPN
dpc-5172	383	15	cosmeceuticals	cosmeceutical	NOUN
dpc-5172	383	16	in	in	ADP
dpc-5172	383	17	photoaging	photoage	VERB
dpc-5172	383	18	:	:	PUNCT
dpc-5172	383	19	a	a	DET
dpc-5172	383	20	review	review	NOUN
dpc-5172	383	21	.	.	PUNCT
dpc-5172	383	22	  	  	SPACE
dpc-5172	383	23	skin	skin	NOUN
dpc-5172	383	24	res	re	NOUN
dpc-5172	383	25	technol	technol	NOUN
dpc-5172	383	26	.	.	PUNCT
dpc-5172	384	1	2024;30(9):e13730	2024;30(9):e13730	NUM
dpc-5172	384	2	.	.	PUNCT
dpc-5172	385	1	doi:10.1111	doi:10.1111	NOUN
dpc-5172	385	2	/	/	SYM
dpc-5172	385	3	srt.13730	srt.13730	NUM
dpc-5172	385	4	.	.	PUNCT
dpc-5172	386	1	pmid	pmid	NOUN
dpc-5172	386	2	:	:	PUNCT
dpc-5172	386	3	39233460	39233460	NUM
dpc-5172	386	4	.	.	PUNCT
dpc-5172	387	1	11	11	NUM
dpc-5172	387	2	.	.	X
dpc-5172	387	3	o'connor	o'connor	PROPN
dpc-5172	387	4	aa	aa	PROPN
dpc-5172	387	5	,	,	PUNCT
dpc-5172	387	6	lowe	lowe	PROPN
dpc-5172	387	7	pm	pm	PROPN
dpc-5172	387	8	,	,	PUNCT
dpc-5172	387	9	shumack	shumack	VERB
dpc-5172	387	10	s	s	PROPN
dpc-5172	387	11	,	,	PUNCT
dpc-5172	387	12	lim	lim	PROPN
dpc-5172	387	13	ac	ac	PROPN
dpc-5172	387	14	.	.	PUNCT
dpc-5172	388	1	chemical	chemical	PROPN
dpc-5172	388	2	peels	peels	PROPN
dpc-5172	388	3	:	:	PUNCT
dpc-5172	388	4	a	a	DET
dpc-5172	388	5	review	review	NOUN
dpc-5172	388	6	of	of	ADP
dpc-5172	388	7	current	current	ADJ
dpc-5172	388	8	practice	practice	NOUN
dpc-5172	388	9	.	.	PUNCT
dpc-5172	388	10	 	 	SPACE
dpc-5172	389	1	australas	australa	VERB
dpc-5172	389	2	j	j	PROPN
dpc-5172	389	3	dermatol	dermatol	NOUN
dpc-5172	389	4	.	.	PUNCT
dpc-5172	390	1	2018;59(3	2018;59(3	NUM
dpc-5172	390	2	):	):	PUNCT
dpc-5172	390	3	171	171	NUM
dpc-5172	390	4	-	-	SYM
dpc-5172	390	5	181	181	NUM
dpc-5172	390	6	.	.	PUNCT
dpc-5172	391	1	doi:10.1111	doi:10.1111	NOUN
dpc-5172	391	2	/	/	SYM
dpc-5172	391	3	ajd.12715	ajd.12715	NOUN
dpc-5172	391	4	.	.	PUNCT
dpc-5172	392	1	pmid:29064096	pmid:29064096	NOUN
dpc-5172	392	2	.	.	PROPN
dpc-5172	393	1	12	12	NUM
dpc-5172	393	2	.	.	PUNCT
dpc-5172	394	1	fitzpatrick	fitzpatrick	PROPN
dpc-5172	394	2	re	re	PROPN
dpc-5172	394	3	,	,	PUNCT
dpc-5172	394	4	goldman	goldman	PROPN
dpc-5172	394	5	mp	mp	PROPN
dpc-5172	394	6	,	,	PUNCT
dpc-5172	394	7	satur	satur	PROPN
dpc-5172	394	8	nm	nm	PROPN
dpc-5172	394	9	,	,	PUNCT
dpc-5172	394	10	tope	tope	PROPN
dpc-5172	394	11	wd	wd	PROPN
dpc-5172	394	12	.	.	PROPN
dpc-5172	394	13	pulsed	pulse	VERB
dpc-5172	394	14	carbon	carbon	NOUN
dpc-5172	394	15	dioxide	dioxide	NOUN
dpc-5172	394	16	laser	laser	NOUN
dpc-5172	394	17	resurfacing	resurfacing	NOUN
dpc-5172	394	18	of	of	ADP
dpc-5172	394	19	photo	photo	NOUN
dpc-5172	394	20	-	-	PUNCT
dpc-5172	394	21	aged	age	VERB
dpc-5172	394	22	facial	facial	ADJ
dpc-5172	394	23	skin	skin	NOUN
dpc-5172	394	24	.	.	PUNCT
dpc-5172	394	25	  	  	SPACE
dpc-5172	395	1	arch	arch	ADJ
dpc-5172	395	2	dermatol	dermatol	NOUN
dpc-5172	395	3	.	.	PUNCT
dpc-5172	396	1	1996;132(4):395	1996;132(4):395	NUM
dpc-5172	396	2	-	-	SYM
dpc-5172	396	3	402	402	NUM
dpc-5172	396	4	.	.	PUNCT
dpc-5172	397	1	pmid	pmid	NOUN
dpc-5172	397	2	:	:	PUNCT
dpc-5172	397	3	8629842	8629842	NUM
dpc-5172	397	4	.	.	PUNCT
dpc-5172	398	1	13	13	NUM
dpc-5172	398	2	.	.	PUNCT
dpc-5172	399	1	guida	guida	PROPN
dpc-5172	399	2	s	s	PROPN
dpc-5172	399	3	,	,	PUNCT
dpc-5172	399	4	ciardo	ciardo	NOUN
dpc-5172	399	5	s	s	NOUN
dpc-5172	399	6	,	,	PUNCT
dpc-5172	399	7	galadari	galadari	ADJ
dpc-5172	399	8	h	h	NOUN
dpc-5172	399	9	,	,	PUNCT
dpc-5172	399	10	et	et	PROPN
dpc-5172	399	11	al	al	PROPN
dpc-5172	399	12	.	.	PUNCT
dpc-5172	400	1	correlating	correlate	VERB
dpc-5172	400	2	optical	optical	ADJ
dpc-5172	400	3	coherence	coherence	NOUN
dpc-5172	400	4	tomography	tomography	NOUN
dpc-5172	400	5	and	and	CCONJ
dpc-5172	400	6	other	other	ADJ
dpc-5172	400	7	noninvasive	noninvasive	ADJ
dpc-5172	400	8	imaging	imaging	NOUN
dpc-5172	400	9	features	feature	NOUN
dpc-5172	400	10	with	with	ADP
dpc-5172	400	11	atrophic	atrophic	ADJ
dpc-5172	400	12	and	and	CCONJ
dpc-5172	400	13	hypertrophic	hypertrophic	ADJ
dpc-5172	400	14	skin	skin	NOUN
dpc-5172	400	15	photoaging	photoage	VERB
dpc-5172	400	16	.	.	PUNCT
dpc-5172	400	17	  	  	SPACE
dpc-5172	400	18	int	int	PROPN
dpc-5172	400	19	j	j	PROPN
dpc-5172	400	20	dermatol	dermatol	NOUN
dpc-5172	400	21	.	.	PUNCT
dpc-5172	401	1	2025;64(8):1441	2025;64(8):1441	NUM
dpc-5172	401	2	-	-	PUNCT
dpc-5172	401	3	1445	1445	NUM
dpc-5172	401	4	.	.	PUNCT
dpc-5172	402	1	doi:10.1111	doi:10.1111	PROPN
dpc-5172	402	2	/	/	SYM
dpc-5172	402	3	ijd.17799	ijd.17799	PROPN
dpc-5172	402	4	.	.	PUNCT
dpc-5172	403	1	pmid	pmid	NOUN
dpc-5172	403	2	:	:	PUNCT
dpc-5172	403	3	40248983	40248983	NUM
dpc-5172	403	4	.	.	PUNCT
dpc-5172	404	1	14	14	NUM
dpc-5172	404	2	.	.	PUNCT
dpc-5172	405	1	hanna	hanna	PROPN
dpc-5172	405	2	e	e	PROPN
dpc-5172	405	3	,	,	PUNCT
dpc-5172	405	4	xing	xing	PROPN
dpc-5172	405	5	l	l	PROPN
dpc-5172	405	6	,	,	PUNCT
dpc-5172	405	7	taylor	taylor	PROPN
dpc-5172	405	8	jh	jh	PROPN
dpc-5172	405	9	,	,	PUNCT
dpc-5172	405	10	bertucci	bertucci	NOUN
dpc-5172	405	11	v.	v.	ADP
dpc-5172	405	12	role	role	NOUN
dpc-5172	405	13	of	of	ADP
dpc-5172	405	14	botulinum	botulinum	ADJ
dpc-5172	405	15	toxin	toxin	NOUN
dpc-5172	405	16	a	a	PRON
dpc-5172	405	17	in	in	ADP
dpc-5172	405	18	improving	improve	VERB
dpc-5172	405	19	facial	facial	ADJ
dpc-5172	405	20	erythema	erythema	NOUN
dpc-5172	405	21	and	and	CCONJ
dpc-5172	405	22	skin	skin	NOUN
dpc-5172	405	23	quality	quality	NOUN
dpc-5172	405	24	.	.	PUNCT
dpc-5172	405	25	 	 	SPACE
dpc-5172	406	1	arch	arch	ADJ
dpc-5172	406	2	dermatol	dermatol	NOUN
dpc-5172	406	3	res	re	NOUN
dpc-5172	406	4	.	.	PUNCT
dpc-5172	407	1	2022;314(8):729	2022;314(8):729	X
dpc-5172	407	2	-	-	SYM
dpc-5172	407	3	738	738	NUM
dpc-5172	407	4	.	.	PUNCT
dpc-5172	407	5	doi:10.1007	doi:10.1007	VERB
dpc-5172	407	6	/	/	SYM
dpc-5172	407	7	s00403	s00403	NOUN
dpc-5172	407	8	-	-	PUNCT
dpc-5172	407	9	021	021	NUM
dpc-5172	407	10	-	-	PUNCT
dpc-5172	407	11	02277	02277	NUM
dpc-5172	407	12	-	-	PUNCT
dpc-5172	407	13	0	0	NUM
dpc-5172	407	14	.	.	PUNCT
dpc-5172	408	1	pmid	pmid	NOUN
dpc-5172	408	2	:	:	PUNCT
dpc-5172	408	3	34519860	34519860	NUM
dpc-5172	408	4	.	.	PUNCT
dpc-5172	409	1	15	15	NUM
dpc-5172	409	2	.	.	X
dpc-5172	409	3	sachs	sachs	PROPN
dpc-5172	409	4	dl	dl	PROPN
dpc-5172	409	5	,	,	PUNCT
dpc-5172	409	6	varani	varani	PROPN
dpc-5172	409	7	j	j	PROPN
dpc-5172	409	8	,	,	PUNCT
dpc-5172	409	9	chubb	chubb	PROPN
dpc-5172	409	10	h	h	PROPN
dpc-5172	409	11	,	,	PUNCT
dpc-5172	409	12	et	et	PROPN
dpc-5172	409	13	al	al	PROPN
dpc-5172	409	14	.	.	PROPN
dpc-5172	410	1	atrophic	atrophic	ADJ
dpc-5172	410	2	and	and	CCONJ
dpc-5172	410	3	hypertrophic	hypertrophic	ADJ
dpc-5172	410	4	photoaging	photoaging	NOUN
dpc-5172	410	5	:	:	PUNCT
dpc-5172	410	6	clinical	clinical	ADJ
dpc-5172	410	7	,	,	PUNCT
dpc-5172	410	8	histologic	histologic	ADJ
dpc-5172	410	9	,	,	PUNCT
dpc-5172	410	10	and	and	CCONJ
dpc-5172	410	11	molecular	molecular	ADJ
dpc-5172	410	12	features	feature	NOUN
dpc-5172	410	13	of	of	ADP
dpc-5172	410	14	2	2	NUM
dpc-5172	410	15	distinct	distinct	ADJ
dpc-5172	410	16	phenotypes	phenotype	NOUN
dpc-5172	410	17	of	of	ADP
dpc-5172	410	18	photoaged	photoage	VERB
dpc-5172	410	19	skin	skin	NOUN
dpc-5172	410	20	.	.	PUNCT
dpc-5172	410	21	 	 	SPACE
dpc-5172	411	1	j	j	PROPN
dpc-5172	411	2	am	be	AUX
dpc-5172	411	3	acad	acad	ADJ
dpc-5172	411	4	dermatol	dermatol	NOUN
dpc-5172	411	5	.	.	PUNCT
dpc-5172	412	1	2019;81(2):480	2019;81(2):480	NOUN
dpc-5172	412	2	-	-	SYM
dpc-5172	412	3	488	488	NUM
dpc-5172	412	4	.	.	PUNCT
dpc-5172	413	1	doi:10.1016	doi:10.1016	PROPN
dpc-5172	413	2	/	/	SYM
dpc-5172	413	3	j.jaad.2019.03.081	j.jaad.2019.03.081	PROPN
dpc-5172	413	4	.	.	PUNCT
dpc-5172	414	1	pmid	pmid	NOUN
dpc-5172	414	2	:	:	PUNCT
dpc-5172	414	3	30954583	30954583	NUM
dpc-5172	414	4	.	.	PUNCT
dpc-5172	415	1	16	16	NUM
dpc-5172	415	2	.	.	PUNCT
dpc-5172	416	1	rovatti	rovatti	VERB
dpc-5172	416	2	pp	pp	ADV
dpc-5172	416	3	,	,	PUNCT
dpc-5172	416	4	pellacani	pellacani	VERB
dpc-5172	416	5	g	g	PROPN
dpc-5172	416	6	,	,	PUNCT
dpc-5172	416	7	guida	guida	PROPN
dpc-5172	416	8	s.	s.	PROPN
dpc-5172	416	9	hyperdiluted	hyperdilute	VERB
dpc-5172	416	10	calcium	calcium	NOUN
dpc-5172	416	11	hydroxylapatite	hydroxylapatite	ADJ
dpc-5172	416	12	1	1	NUM
dpc-5172	416	13	:	:	SYM
dpc-5172	416	14	2	2	NUM
dpc-5172	416	15	for	for	ADP
dpc-5172	416	16	mid	mid	ADJ
dpc-5172	416	17	and	and	CCONJ
dpc-5172	416	18	lower	low	ADJ
dpc-5172	416	19	facial	facial	ADJ
dpc-5172	416	20	skin	skin	NOUN
dpc-5172	416	21	rejuvenation	rejuvenation	NOUN
dpc-5172	416	22	:	:	PUNCT
dpc-5172	416	23	efficacy	efficacy	NOUN
dpc-5172	416	24	and	and	CCONJ
dpc-5172	416	25	safety	safety	NOUN
dpc-5172	416	26	.	.	PUNCT
dpc-5172	416	27	  	  	SPACE
dpc-5172	416	28	dermatol	dermatol	ADJ
dpc-5172	416	29	surg	surg	NOUN
dpc-5172	416	30	.	.	PUNCT
dpc-5172	417	1	2020;46(12):e112	2020;46(12):e112	PROPN
dpc-5172	417	2	-	-	PUNCT
dpc-5172	417	3	e117	e117	PROPN
dpc-5172	417	4	.	.	PUNCT
dpc-5172	418	1	doi:10.1097	doi:10.1097	PROPN
dpc-5172	418	2	/	/	SYM
dpc-5172	418	3	dss.0000000000002375	dss.0000000000002375	NOUN
dpc-5172	418	4	.	.	PUNCT
dpc-5172	419	1	pmid	pmid	NOUN
dpc-5172	419	2	:	:	PUNCT
dpc-5172	419	3	32205749	32205749	NUM
dpc-5172	419	4	.	.	PUNCT
dpc-5172	420	1	17	17	NUM
dpc-5172	420	2	.	.	PUNCT
dpc-5172	421	1	somenek	somenek	PROPN
dpc-5172	421	2	m.	m.	PROPN
dpc-5172	421	3	hyperdilute	hyperdilute	PROPN
dpc-5172	421	4	calcium	calcium	NOUN
dpc-5172	421	5	hydroxylapatite	hydroxylapatite	NOUN
dpc-5172	421	6	for	for	ADP
dpc-5172	421	7	the	the	DET
dpc-5172	421	8	treatment	treatment	NOUN
dpc-5172	421	9	of	of	ADP
dpc-5172	421	10	perioral	perioral	ADJ
dpc-5172	421	11	rhytids	rhytid	NOUN
dpc-5172	421	12	:	:	PUNCT
dpc-5172	421	13	a	a	DET
dpc-5172	421	14	pilot	pilot	NOUN
dpc-5172	421	15	study	study	NOUN
dpc-5172	421	16	.	.	PUNCT
dpc-5172	421	17	 	 	SPACE
dpc-5172	421	18	aesthet	aesthet	PROPN
dpc-5172	421	19	surg	surg	PROPN
dpc-5172	421	20	j	j	PROPN
dpc-5172	421	21	open	open	PROPN
dpc-5172	421	22	forum	forum	PROPN
dpc-5172	421	23	.	.	PUNCT
dpc-5172	422	1	2024;6	2024;6	NUM
dpc-5172	422	2	:	:	PUNCT
dpc-5172	422	3	ojae021	ojae021	NUM
dpc-5172	422	4	.	.	PUNCT
dpc-5172	422	5	published	publish	VERB
dpc-5172	422	6	2024	2024	NUM
dpc-5172	422	7	apr	apr	NOUN
dpc-5172	422	8	5	5	NUM
dpc-5172	422	9	.	.	PUNCT
dpc-5172	422	10	doi:10.1093	doi:10.1093	NOUN
dpc-5172	422	11	/	/	SYM
dpc-5172	422	12	asjof	asjof	VERB
dpc-5172	422	13	/ojae021	/ojae021	PROPN
dpc-5172	422	14	.	.	PUNCT
dpc-5172	423	1	pmid	pmid	NOUN
dpc-5172	423	2	:	:	PUNCT
dpc-5172	423	3	38660236	38660236	NUM
dpc-5172	423	4	.	.	PUNCT
dpc-5172	424	1	18	18	NUM
dpc-5172	424	2	.	.	X
dpc-5172	424	3	tj	tj	PROPN
dpc-5172	424	4	higgins	higgins	PROPN
dpc-5172	424	5	jpt	jpt	PROPN
dpc-5172	424	6	,	,	PUNCT
dpc-5172	424	7	chandler	chandler	PROPN
dpc-5172	424	8	j	j	PROPN
dpc-5172	424	9	,	,	PUNCT
dpc-5172	424	10	cumpston	cumpston	PROPN
dpc-5172	424	11	m	m	PROPN
dpc-5172	424	12	,	,	PUNCT
dpc-5172	424	13	li	li	PROPN
dpc-5172	424	14	t	t	PROPN
dpc-5172	424	15	,	,	PUNCT
dpc-5172	424	16	page	page	NOUN
dpc-5172	424	17	mj	mj	PROPN
dpc-5172	424	18	,	,	PUNCT
dpc-5172	424	19	welch	welch	PROPN
dpc-5172	424	20	va	va	PROPN
dpc-5172	424	21	,	,	PUNCT
dpc-5172	424	22	cochrane	cochrane	PROPN
dpc-5172	424	23	handbook	handbook	NOUN
dpc-5172	424	24	for	for	ADP
dpc-5172	424	25	systematic	systematic	ADJ
dpc-5172	424	26	reviews	review	NOUN
dpc-5172	424	27	of	of	ADP
dpc-5172	424	28	interventions	intervention	NOUN
dpc-5172	424	29	version	version	NOUN
dpc-5172	424	30	6.5	6.5	NUM
dpc-5172	424	31	,	,	PUNCT
dpc-5172	424	32	cochrane	cochrane	NOUN
dpc-5172	424	33	,	,	PUNCT
dpc-5172	424	34	2024	2024	NUM
dpc-5172	424	35	.	.	PUNCT