id	sid	tid	token	lemma	pos
dpc-5329	1	1	dermatology	dermatology	NOUN
dpc-5329	1	2	:	:	PUNCT
dpc-5329	1	3	practical	practical	ADJ
dpc-5329	1	4	and	and	CCONJ
dpc-5329	1	5	conceptual	conceptual	ADJ
dpc-5329	1	6	review	review	NOUN
dpc-5329	1	7	|	|	ADV
dpc-5329	1	8	dermatol	dermatol	ADJ
dpc-5329	1	9	pract	pract	NOUN
dpc-5329	1	10	concept	concept	NOUN
dpc-5329	1	11	.	.	PUNCT
dpc-5329	2	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	2	2	1	1	NUM
dpc-5329	2	3	skin	skin	NOUN
dpc-5329	2	4	-	-	PUNCT
dpc-5329	2	5	immune	immune	NOUN
dpc-5329	2	6	-	-	PUNCT
dpc-5329	2	7	neuro	neuro	NOUN
dpc-5329	2	8	-	-	PUNCT
dpc-5329	2	9	gastro	gastro	NOUN
dpc-5329	2	10	-	-	PUNCT
dpc-5329	2	11	endocrine	endocrine	NOUN
dpc-5329	2	12	(	(	PUNCT
dpc-5329	2	13	singe	singe	NOUN
dpc-5329	2	14	)	)	PUNCT
dpc-5329	2	15	system	system	NOUN
dpc-5329	2	16	:	:	PUNCT
dpc-5329	2	17	lighting	light	VERB
dpc-5329	2	18	the	the	DET
dpc-5329	2	19	fire	fire	NOUN
dpc-5329	2	20	on	on	ADP
dpc-5329	2	21	atopic	atopic	NOUN
dpc-5329	2	22	dermatitis	dermatitis	NOUN
dpc-5329	2	23	research	research	NOUN
dpc-5329	2	24	meshi	meshi	PROPN
dpc-5329	2	25	paz1	paz1	PROPN
dpc-5329	2	26	,	,	PUNCT
dpc-5329	2	27	peter	peter	PROPN
dpc-5329	2	28	lio2,3	lio2,3	PROPN
dpc-5329	2	29	1	1	NUM
dpc-5329	2	30	tulane	tulane	NOUN
dpc-5329	2	31	university	university	NOUN
dpc-5329	2	32	school	school	NOUN
dpc-5329	2	33	of	of	ADP
dpc-5329	2	34	medicine	medicine	NOUN
dpc-5329	2	35	,	,	PUNCT
dpc-5329	2	36	new	new	PROPN
dpc-5329	2	37	orleans	orleans	PROPN
dpc-5329	2	38	,	,	PUNCT
dpc-5329	2	39	usa	usa	PROPN
dpc-5329	2	40	2	2	NUM
dpc-5329	2	41	feinberg	feinberg	PROPN
dpc-5329	2	42	school	school	NOUN
dpc-5329	2	43	of	of	ADP
dpc-5329	2	44	medicine	medicine	NOUN
dpc-5329	2	45	,	,	PUNCT
dpc-5329	2	46	northwestern	northwestern	ADJ
dpc-5329	2	47	university	university	NOUN
dpc-5329	2	48	,	,	PUNCT
dpc-5329	2	49	chicago	chicago	PROPN
dpc-5329	2	50	,	,	PUNCT
dpc-5329	2	51	usa	usa	PROPN
dpc-5329	2	52	3	3	NUM
dpc-5329	2	53	medical	medical	ADJ
dpc-5329	2	54	dermatology	dermatology	NOUN
dpc-5329	2	55	associates	associate	NOUN
dpc-5329	2	56	of	of	ADP
dpc-5329	2	57	chicago	chicago	PROPN
dpc-5329	2	58	,	,	PUNCT
dpc-5329	2	59	chicago	chicago	PROPN
dpc-5329	2	60	,	,	PUNCT
dpc-5329	2	61	usa	usa	PROPN
dpc-5329	2	62	key	key	NOUN
dpc-5329	2	63	words	word	NOUN
dpc-5329	2	64	:	:	PUNCT
dpc-5329	2	65	atopic	atopic	NOUN
dpc-5329	2	66	dermatitis	dermatitis	NOUN
dpc-5329	2	67	,	,	PUNCT
dpc-5329	2	68	neuroimmunology	neuroimmunology	NOUN
dpc-5329	2	69	,	,	PUNCT
dpc-5329	2	70	gut	gut	NOUN
dpc-5329	2	71	-	-	PUNCT
dpc-5329	2	72	skin	skin	NOUN
dpc-5329	2	73	axis	axis	NOUN
dpc-5329	2	74	,	,	PUNCT
dpc-5329	2	75	itch	itch	NOUN
dpc-5329	2	76	-	-	PUNCT
dpc-5329	2	77	scratch	scratch	NOUN
dpc-5329	2	78	cycle	cycle	NOUN
dpc-5329	2	79	,	,	PUNCT
dpc-5329	2	80	neuroendocrine	neuroendocrine	ADJ
dpc-5329	2	81	microbiome	microbiome	ADJ
dpc-5329	2	82	citation	citation	NOUN
dpc-5329	2	83	:	:	PUNCT
dpc-5329	2	84	paz	paz	PROPN
dpc-5329	2	85	m	m	PROPN
dpc-5329	2	86	,	,	PUNCT
dpc-5329	2	87	lio	lio	PROPN
dpc-5329	2	88	p.	p.	PROPN
dpc-5329	2	89	skin	skin	NOUN
dpc-5329	2	90	-	-	PUNCT
dpc-5329	2	91	immune	immune	NOUN
dpc-5329	2	92	-	-	PUNCT
dpc-5329	2	93	neuro	neuro	NOUN
dpc-5329	2	94	-	-	PUNCT
dpc-5329	2	95	gastro	gastro	NOUN
dpc-5329	2	96	-	-	PUNCT
dpc-5329	2	97	endocrine	endocrine	NOUN
dpc-5329	2	98	(	(	PUNCT
dpc-5329	2	99	singe	singe	NOUN
dpc-5329	2	100	)	)	PUNCT
dpc-5329	2	101	system	system	NOUN
dpc-5329	2	102	:	:	PUNCT
dpc-5329	2	103	lighting	light	VERB
dpc-5329	2	104	the	the	DET
dpc-5329	2	105	fire	fire	NOUN
dpc-5329	2	106	on	on	ADP
dpc-5329	2	107	atopic	atopic	NOUN
dpc-5329	2	108	dermatitis	dermatitis	NOUN
dpc-5329	2	109	research	research	NOUN
dpc-5329	2	110	.	.	PUNCT
dpc-5329	3	1	dermatol	dermatol	NOUN
dpc-5329	3	2	pract	pract	PROPN
dpc-5329	3	3	concept	concept	NOUN
dpc-5329	3	4	.	.	PUNCT
dpc-5329	4	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	4	2	.	.	PUNCT
dpc-5329	5	1	doi	doi	NOUN
dpc-5329	5	2	:	:	PUNCT
dpc-5329	5	3	https://doi.org/10.5826/dpc.1504a5329	https://doi.org/10.5826/dpc.1504a5329	PROPN
dpc-5329	5	4	accepted	accept	VERB
dpc-5329	5	5	:	:	PUNCT
dpc-5329	5	6	april	april	PROPN
dpc-5329	5	7	1	1	NUM
dpc-5329	5	8	,	,	PUNCT
dpc-5329	5	9	2025	2025	NUM
dpc-5329	5	10	;	;	PUNCT
dpc-5329	5	11	published	publish	VERB
dpc-5329	5	12	:	:	PUNCT
dpc-5329	6	1	october	october	PROPN
dpc-5329	6	2	2025	2025	NUM
dpc-5329	6	3	copyright	copyright	NOUN
dpc-5329	6	4	:	:	PUNCT
dpc-5329	6	5	©	©	PROPN
dpc-5329	6	6	2025	2025	NUM
dpc-5329	6	7	paz	paz	NOUN
dpc-5329	6	8	et	et	PROPN
dpc-5329	6	9	al	al	PROPN
dpc-5329	6	10	.	.	PUNCT
dpc-5329	7	1	this	this	PRON
dpc-5329	7	2	is	be	AUX
dpc-5329	7	3	an	an	DET
dpc-5329	7	4	open	open	ADJ
dpc-5329	7	5	-	-	PUNCT
dpc-5329	7	6	access	access	NOUN
dpc-5329	7	7	article	article	NOUN
dpc-5329	7	8	distributed	distribute	VERB
dpc-5329	7	9	under	under	ADP
dpc-5329	7	10	the	the	DET
dpc-5329	7	11	terms	term	NOUN
dpc-5329	7	12	of	of	ADP
dpc-5329	7	13	the	the	DET
dpc-5329	7	14	creative	creative	ADJ
dpc-5329	7	15	commons	common	NOUN
dpc-5329	7	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-5329	7	17	license	license	NOUN
dpc-5329	7	18	(	(	PUNCT
dpc-5329	7	19	by	by	ADP
dpc-5329	7	20	-	-	PUNCT
dpc-5329	7	21	nc-4.0	nc-4.0	NOUN
dpc-5329	7	22	)	)	PUNCT
dpc-5329	7	23	,	,	PUNCT
dpc-5329	7	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-5329	7	25	,	,	PUNCT
dpc-5329	7	26	which	which	PRON
dpc-5329	7	27	permits	permit	VERB
dpc-5329	7	28	unrestricted	unrestricted	ADJ
dpc-5329	7	29	noncommercial	noncommercial	ADJ
dpc-5329	7	30	use	use	NOUN
dpc-5329	7	31	,	,	PUNCT
dpc-5329	7	32	distribution	distribution	NOUN
dpc-5329	7	33	,	,	PUNCT
dpc-5329	7	34	and	and	CCONJ
dpc-5329	7	35	reproduction	reproduction	NOUN
dpc-5329	7	36	in	in	ADP
dpc-5329	7	37	any	any	DET
dpc-5329	7	38	medium	medium	NOUN
dpc-5329	7	39	,	,	PUNCT
dpc-5329	7	40	provided	provide	VERB
dpc-5329	7	41	the	the	DET
dpc-5329	7	42	original	original	ADJ
dpc-5329	7	43	authors	author	NOUN
dpc-5329	7	44	and	and	CCONJ
dpc-5329	7	45	source	source	NOUN
dpc-5329	7	46	are	be	AUX
dpc-5329	7	47	credited	credit	VERB
dpc-5329	7	48	.	.	PUNCT
dpc-5329	8	1	funding	funding	NOUN
dpc-5329	8	2	:	:	PUNCT
dpc-5329	8	3	none	none	NOUN
dpc-5329	8	4	.	.	PUNCT
dpc-5329	9	1	competing	compete	VERB
dpc-5329	9	2	interests	interest	NOUN
dpc-5329	9	3	:	:	PUNCT
dpc-5329	9	4	dr	dr	PROPN
dpc-5329	9	5	.	.	PROPN
dpc-5329	9	6	peter	peter	PROPN
dpc-5329	9	7	lio	lio	PROPN
dpc-5329	9	8	reports	report	VERB
dpc-5329	9	9	research	research	NOUN
dpc-5329	9	10	grants	grant	NOUN
dpc-5329	9	11	/	/	SYM
dpc-5329	9	12	funding	funding	NOUN
dpc-5329	9	13	from	from	ADP
dpc-5329	9	14	abbvie	abbvie	PROPN
dpc-5329	9	15	,	,	PUNCT
dpc-5329	9	16	aobiome	aobiome	PROPN
dpc-5329	9	17	,	,	PUNCT
dpc-5329	9	18	and	and	CCONJ
dpc-5329	9	19	regeneron	regeneron	PROPN
dpc-5329	9	20	/	/	SYM
dpc-5329	9	21	sanofi	sanofi	PROPN
dpc-5329	9	22	,	,	PUNCT
dpc-5329	9	23	genzyme	genzyme	PROPN
dpc-5329	9	24	,	,	PUNCT
dpc-5329	9	25	is	be	AUX
dpc-5329	9	26	on	on	ADP
dpc-5329	9	27	the	the	DET
dpc-5329	9	28	speaker	speaker	NOUN
dpc-5329	9	29	’s	’s	PART
dpc-5329	9	30	bureau	bureau	PROPN
dpc-5329	9	31	for	for	ADP
dpc-5329	9	32	abbvie	abbvie	PROPN
dpc-5329	9	33	,	,	PUNCT
dpc-5329	9	34	eli	eli	PROPN
dpc-5329	9	35	lilly	lilly	PROPN
dpc-5329	9	36	,	,	PUNCT
dpc-5329	9	37	galderma	galderma	NOUN
dpc-5329	9	38	,	,	PUNCT
dpc-5329	9	39	hyphens	hyphen	NOUN
dpc-5329	9	40	,	,	PUNCT
dpc-5329	9	41	incyte	incyte	PROPN
dpc-5329	9	42	,	,	PUNCT
dpc-5329	9	43	leo	leo	PROPN
dpc-5329	9	44	pharma	pharma	PROPN
dpc-5329	9	45	,	,	PUNCT
dpc-5329	9	46	l'oreal	l'oreal	PROPN
dpc-5329	9	47	,	,	PUNCT
dpc-5329	9	48	myor	myor	NOUN
dpc-5329	9	49	diagnostics	diagnostic	NOUN
dpc-5329	9	50	,	,	PUNCT
dpc-5329	9	51	parentmd	parentmd	NOUN
dpc-5329	9	52	,	,	PUNCT
dpc-5329	9	53	pfizer	pfizer	NOUN
dpc-5329	9	54	,	,	PUNCT
dpc-5329	9	55	and	and	CCONJ
dpc-5329	9	56	regeneron	regeneron	PROPN
dpc-5329	9	57	/	/	SYM
dpc-5329	9	58	sanofi	sanofi	PROPN
dpc-5329	9	59	genzyme	genzyme	PROPN
dpc-5329	9	60	,	,	PUNCT
dpc-5329	9	61	and	and	CCONJ
dpc-5329	9	62	reports	report	VERB
dpc-5329	9	63	consulting	consulting	NOUN
dpc-5329	9	64	/	/	SYM
dpc-5329	9	65	advisory	advisory	ADJ
dpc-5329	9	66	boards	board	NOUN
dpc-5329	9	67	for	for	ADP
dpc-5329	9	68	abbvie	abbvie	PROPN
dpc-5329	9	69	,	,	PUNCT
dpc-5329	9	70	almirall	almirall	ADJ
dpc-5329	9	71	,	,	PUNCT
dpc-5329	9	72	amyris	amyris	ADV
dpc-5329	9	73	,	,	PUNCT
dpc-5329	9	74	aobiome	aobiome	PROPN
dpc-5329	9	75	,	,	PUNCT
dpc-5329	9	76	arbonne	arbonne	PROPN
dpc-5329	9	77	,	,	PUNCT
dpc-5329	9	78	aslan	aslan	PROPN
dpc-5329	9	79	pharmaceuticals	pharmaceuticals	PROPN
dpc-5329	9	80	,	,	PUNCT
dpc-5329	9	81	burt	burt	PROPN
dpc-5329	9	82	’s	’s	PART
dpc-5329	9	83	bees	bee	NOUN
dpc-5329	9	84	,	,	PUNCT
dpc-5329	9	85	castle	castle	NOUN
dpc-5329	9	86	biosciences	bioscience	NOUN
dpc-5329	9	87	,	,	PUNCT
dpc-5329	9	88	codex	codex	PROPN
dpc-5329	9	89	labs	labs	PROPN
dpc-5329	9	90	,	,	PUNCT
dpc-5329	9	91	concerto	concerto	ADJ
dpc-5329	9	92	biosciences	bioscience	NOUN
dpc-5329	9	93	(	(	PUNCT
dpc-5329	9	94	stock	stock	NOUN
dpc-5329	9	95	options	option	NOUN
dpc-5329	9	96	)	)	PUNCT
dpc-5329	9	97	,	,	PUNCT
dpc-5329	9	98	dermavant	dermavant	PROPN
dpc-5329	9	99	,	,	PUNCT
dpc-5329	9	100	eli	eli	PROPN
dpc-5329	9	101	lilly	lilly	PROPN
dpc-5329	9	102	,	,	PUNCT
dpc-5329	9	103	exeltis	exeltis	PROPN
dpc-5329	9	104	,	,	PUNCT
dpc-5329	9	105	galderma	galderma	NOUN
dpc-5329	9	106	,	,	PUNCT
dpc-5329	9	107	intraderm	intraderm	NOUN
dpc-5329	9	108	,	,	PUNCT
dpc-5329	9	109	johnson	johnson	PROPN
dpc-5329	9	110	&	&	CCONJ
dpc-5329	9	111	amp	amp	PROPN
dpc-5329	9	112	;	;	PUNCT
dpc-5329	9	113	johnson	johnson	PROPN
dpc-5329	9	114	,	,	PUNCT
dpc-5329	9	115	leo	leo	PROPN
dpc-5329	9	116	pharma	pharma	PROPN
dpc-5329	9	117	,	,	PUNCT
dpc-5329	9	118	l’oreal	l’oreal	PROPN
dpc-5329	9	119	,	,	PUNCT
dpc-5329	9	120	menlo	menlo	NOUN
dpc-5329	9	121	therapeutics	therapeutic	NOUN
dpc-5329	9	122	,	,	PUNCT
dpc-5329	9	123	micreos	micreo	NOUN
dpc-5329	9	124	,	,	PUNCT
dpc-5329	9	125	pfizer	pfizer	NOUN
dpc-5329	9	126	,	,	PUNCT
dpc-5329	9	127	pierre	pierre	PROPN
dpc-5329	9	128	-	-	PUNCT
dpc-5329	9	129	fabre	fabre	PROPN
dpc-5329	9	130	,	,	PUNCT
dpc-5329	9	131	regeneron	regeneron	PROPN
dpc-5329	9	132	/	/	SYM
dpc-5329	9	133	sanofi	sanofi	PROPN
dpc-5329	9	134	genzyme	genzyme	PROPN
dpc-5329	9	135	,	,	PUNCT
dpc-5329	9	136	theraplex	theraplex	NOUN
dpc-5329	9	137	,	,	PUNCT
dpc-5329	9	138	and	and	CCONJ
dpc-5329	9	139	unilever	unilever	PROPN
dpc-5329	9	140	.	.	PUNCT
dpc-5329	10	1	in	in	ADP
dpc-5329	10	2	addition	addition	NOUN
dpc-5329	10	3	,	,	PUNCT
dpc-5329	10	4	dr	dr	PROPN
dpc-5329	10	5	.	.	PROPN
dpc-5329	10	6	lio	lio	PROPN
dpc-5329	10	7	has	have	VERB
dpc-5329	10	8	a	a	DET
dpc-5329	10	9	patent	patent	NOUN
dpc-5329	10	10	pending	pende	VERB
dpc-5329	10	11	for	for	ADP
dpc-5329	10	12	a	a	DET
dpc-5329	10	13	theraplex	theraplex	ADJ
dpc-5329	10	14	product	product	NOUN
dpc-5329	10	15	with	with	ADP
dpc-5329	10	16	royalties	royalty	NOUN
dpc-5329	10	17	paid	pay	VERB
dpc-5329	10	18	and	and	CCONJ
dpc-5329	10	19	is	be	AUX
dpc-5329	10	20	a	a	DET
dpc-5329	10	21	board	board	NOUN
dpc-5329	10	22	member	member	NOUN
dpc-5329	10	23	and	and	CCONJ
dpc-5329	10	24	scientific	scientific	ADJ
dpc-5329	10	25	advisory	advisory	ADJ
dpc-5329	10	26	committee	committee	NOUN
dpc-5329	10	27	member	member	NOUN
dpc-5329	10	28	of	of	ADP
dpc-5329	10	29	the	the	DET
dpc-5329	10	30	national	national	PROPN
dpc-5329	10	31	eczema	eczema	PROPN
dpc-5329	10	32	association	association	PROPN
dpc-5329	10	33	.	.	PUNCT
dpc-5329	11	1	meshi	meshi	PROPN
dpc-5329	11	2	paz	paz	PROPN
dpc-5329	11	3	reports	report	VERB
dpc-5329	11	4	no	no	DET
dpc-5329	11	5	conflicts	conflict	NOUN
dpc-5329	11	6	of	of	ADP
dpc-5329	11	7	interest	interest	NOUN
dpc-5329	11	8	.	.	PUNCT
dpc-5329	12	1	authorship	authorship	NOUN
dpc-5329	12	2	:	:	PUNCT
dpc-5329	12	3	all	all	DET
dpc-5329	12	4	authors	author	NOUN
dpc-5329	12	5	have	have	AUX
dpc-5329	12	6	contributed	contribute	VERB
dpc-5329	12	7	significantly	significantly	ADV
dpc-5329	12	8	to	to	ADP
dpc-5329	12	9	this	this	DET
dpc-5329	12	10	publication	publication	NOUN
dpc-5329	12	11	.	.	PUNCT
dpc-5329	13	1	corresponding	correspond	VERB
dpc-5329	13	2	author	author	NOUN
dpc-5329	13	3	:	:	PUNCT
dpc-5329	13	4	dr	dr	PROPN
dpc-5329	13	5	.	.	PROPN
dpc-5329	13	6	peter	peter	PROPN
dpc-5329	13	7	lio	lio	PROPN
dpc-5329	13	8	,	,	PUNCT
dpc-5329	13	9	md	md	PROPN
dpc-5329	13	10	,	,	PUNCT
dpc-5329	13	11	medical	medical	ADJ
dpc-5329	13	12	dermatology	dermatology	NOUN
dpc-5329	13	13	associates	associate	NOUN
dpc-5329	13	14	of	of	ADP
dpc-5329	13	15	chicago	chicago	PROPN
dpc-5329	13	16	,	,	PUNCT
dpc-5329	13	17	363	363	NUM
dpc-5329	13	18	w	w	PROPN
dpc-5329	13	19	erie	erie	PROPN
dpc-5329	13	20	street	street	PROPN
dpc-5329	13	21	#	#	SYM
dpc-5329	13	22	360	360	NUM
dpc-5329	13	23	,	,	PUNCT
dpc-5329	13	24	chicago	chicago	PROPN
dpc-5329	13	25	,	,	PUNCT
dpc-5329	13	26	il	il	PROPN
dpc-5329	13	27	60654	60654	NUM
dpc-5329	13	28	.	.	PUNCT
dpc-5329	14	1	orcid	orcid	NOUN
dpc-5329	14	2	:	:	PUNCT
dpc-5329	14	3	0000	0000	NUM
dpc-5329	14	4	-	-	PUNCT
dpc-5329	14	5	0001	0001	NUM
dpc-5329	14	6	-	-	PUNCT
dpc-5329	14	7	7600	7600	NUM
dpc-5329	14	8	-	-	PUNCT
dpc-5329	14	9	0152	0152	NUM
dpc-5329	14	10	.	.	PUNCT
dpc-5329	15	1	email	email	NOUN
dpc-5329	15	2	:	:	PUNCT
dpc-5329	16	1	peterlio@gmail.com	peterlio@gmail.com	X
dpc-5329	17	1	introduction	introduction	NOUN
dpc-5329	17	2	:	:	PUNCT
dpc-5329	17	3	atopic	atopic	NOUN
dpc-5329	17	4	dermatitis	dermatitis	NOUN
dpc-5329	17	5	(	(	PUNCT
dpc-5329	17	6	ad	ad	NOUN
dpc-5329	17	7	)	)	PUNCT
dpc-5329	17	8	is	be	AUX
dpc-5329	17	9	a	a	DET
dpc-5329	17	10	chronic	chronic	ADJ
dpc-5329	17	11	inflammatory	inflammatory	ADJ
dpc-5329	17	12	skin	skin	NOUN
dpc-5329	17	13	condition	condition	NOUN
dpc-5329	17	14	characterized	characterize	VERB
dpc-5329	17	15	by	by	ADP
dpc-5329	17	16	pruritic	pruritic	ADJ
dpc-5329	17	17	,	,	PUNCT
dpc-5329	17	18	dry	dry	ADJ
dpc-5329	17	19	,	,	PUNCT
dpc-5329	17	20	eczematous	eczematous	ADJ
dpc-5329	17	21	lesions	lesion	NOUN
dpc-5329	17	22	.	.	PUNCT
dpc-5329	18	1	traditionally	traditionally	ADV
dpc-5329	18	2	regarded	regard	VERB
dpc-5329	18	3	primarily	primarily	ADV
dpc-5329	18	4	as	as	ADP
dpc-5329	18	5	a	a	DET
dpc-5329	18	6	cutaneous	cutaneous	ADJ
dpc-5329	18	7	disorder	disorder	NOUN
dpc-5329	18	8	influenced	influence	VERB
dpc-5329	18	9	by	by	ADP
dpc-5329	18	10	genetic	genetic	ADJ
dpc-5329	18	11	and	and	CCONJ
dpc-5329	18	12	environmental	environmental	ADJ
dpc-5329	18	13	factors	factor	NOUN
dpc-5329	18	14	,	,	PUNCT
dpc-5329	18	15	ad	ad	NOUN
dpc-5329	18	16	is	be	AUX
dpc-5329	18	17	increasingly	increasingly	ADV
dpc-5329	18	18	recognized	recognize	VERB
dpc-5329	18	19	as	as	ADP
dpc-5329	18	20	a	a	DET
dpc-5329	18	21	multisystem	multisystem	NOUN
dpc-5329	18	22	condition	condition	NOUN
dpc-5329	18	23	involving	involve	VERB
dpc-5329	18	24	immune	immune	NOUN
dpc-5329	18	25	,	,	PUNCT
dpc-5329	18	26	microbial	microbial	ADJ
dpc-5329	18	27	,	,	PUNCT
dpc-5329	18	28	and	and	CCONJ
dpc-5329	18	29	neuroendocrine	neuroendocrine	ADJ
dpc-5329	18	30	interactions	interaction	NOUN
dpc-5329	18	31	.	.	PUNCT
dpc-5329	19	1	objectives	objective	NOUN
dpc-5329	19	2	:	:	PUNCT
dpc-5329	19	3	this	this	DET
dpc-5329	19	4	review	review	NOUN
dpc-5329	19	5	proposes	propose	VERB
dpc-5329	19	6	the	the	DET
dpc-5329	19	7	skin	skin	NOUN
dpc-5329	19	8	-	-	PUNCT
dpc-5329	19	9	immune	immune	NOUN
dpc-5329	19	10	-	-	PUNCT
dpc-5329	19	11	neuro	neuro	NOUN
dpc-5329	19	12	-	-	PUNCT
dpc-5329	19	13	gastro	gastro	NOUN
dpc-5329	19	14	-	-	PUNCT
dpc-5329	19	15	endocrine	endocrine	NOUN
dpc-5329	19	16	(	(	PUNCT
dpc-5329	19	17	singe	singe	NOUN
dpc-5329	19	18	)	)	PUNCT
dpc-5329	19	19	network	network	NOUN
dpc-5329	19	20	as	as	ADP
dpc-5329	19	21	a	a	DET
dpc-5329	19	22	comprehensive	comprehensive	ADJ
dpc-5329	19	23	framework	framework	NOUN
dpc-5329	19	24	to	to	PART
dpc-5329	19	25	explore	explore	VERB
dpc-5329	19	26	the	the	DET
dpc-5329	19	27	interconnected	interconnected	ADJ
dpc-5329	19	28	pathophysiology	pathophysiology	NOUN
dpc-5329	19	29	of	of	ADP
dpc-5329	19	30	ad	ad	NOUN
dpc-5329	19	31	.	.	PUNCT
dpc-5329	20	1	the	the	DET
dpc-5329	20	2	aim	aim	NOUN
dpc-5329	20	3	is	be	AUX
dpc-5329	20	4	to	to	PART
dpc-5329	20	5	highlight	highlight	VERB
dpc-5329	20	6	how	how	SCONJ
dpc-5329	20	7	changes	change	NOUN
dpc-5329	20	8	across	across	ADP
dpc-5329	20	9	various	various	ADJ
dpc-5329	20	10	systems	system	NOUN
dpc-5329	20	11	contribute	contribute	VERB
dpc-5329	20	12	to	to	ADP
dpc-5329	20	13	disease	disease	NOUN
dpc-5329	20	14	development	development	NOUN
dpc-5329	20	15	,	,	PUNCT
dpc-5329	20	16	presentation	presentation	NOUN
dpc-5329	20	17	,	,	PUNCT
dpc-5329	20	18	and	and	CCONJ
dpc-5329	20	19	treatment	treatment	NOUN
dpc-5329	20	20	.	.	PUNCT
dpc-5329	21	1	methods	method	NOUN
dpc-5329	21	2	:	:	PUNCT
dpc-5329	21	3	a	a	DET
dpc-5329	21	4	comprehensive	comprehensive	ADJ
dpc-5329	21	5	review	review	NOUN
dpc-5329	21	6	of	of	ADP
dpc-5329	21	7	current	current	ADJ
dpc-5329	21	8	literature	literature	NOUN
dpc-5329	21	9	was	be	AUX
dpc-5329	21	10	performed	perform	VERB
dpc-5329	21	11	,	,	PUNCT
dpc-5329	21	12	examining	examine	VERB
dpc-5329	21	13	the	the	DET
dpc-5329	21	14	roles	role	NOUN
dpc-5329	21	15	of	of	ADP
dpc-5329	21	16	skin	skin	NOUN
dpc-5329	21	17	barrier	barrier	NOUN
dpc-5329	21	18	dysfunction	dysfunction	NOUN
dpc-5329	21	19	,	,	PUNCT
dpc-5329	21	20	immune	immune	ADJ
dpc-5329	21	21	signaling	signal	VERB
dpc-5329	21	22	,	,	PUNCT
dpc-5329	21	23	neuroendocrine	neuroendocrine	ADJ
dpc-5329	21	24	pathways	pathway	NOUN
dpc-5329	21	25	,	,	PUNCT
dpc-5329	21	26	and	and	CCONJ
dpc-5329	21	27	gut	gut	VERB
dpc-5329	21	28	microbial	microbial	ADJ
dpc-5329	21	29	dysbiosis	dysbiosis	NOUN
dpc-5329	21	30	.	.	PUNCT
dpc-5329	22	1	these	these	DET
dpc-5329	22	2	domains	domain	NOUN
dpc-5329	22	3	were	be	AUX
dpc-5329	22	4	integrated	integrate	VERB
dpc-5329	22	5	into	into	ADP
dpc-5329	22	6	a	a	DET
dpc-5329	22	7	unified	unified	ADJ
dpc-5329	22	8	model	model	NOUN
dpc-5329	22	9	that	that	PRON
dpc-5329	22	10	describes	describe	VERB
dpc-5329	22	11	bidirectional	bidirectional	ADJ
dpc-5329	22	12	interactions	interaction	NOUN
dpc-5329	22	13	and	and	CCONJ
dpc-5329	22	14	their	their	PRON
dpc-5329	22	15	clinical	clinical	ADJ
dpc-5329	22	16	implications	implication	NOUN
dpc-5329	22	17	.	.	PUNCT
dpc-5329	23	1	results	result	NOUN
dpc-5329	23	2	:	:	PUNCT
dpc-5329	23	3	the	the	DET
dpc-5329	23	4	singe	singe	NOUN
dpc-5329	23	5	model	model	NOUN
dpc-5329	23	6	reveals	reveal	VERB
dpc-5329	23	7	that	that	SCONJ
dpc-5329	23	8	epidermal	epidermal	ADJ
dpc-5329	23	9	barrier	barrier	NOUN
dpc-5329	23	10	disruption	disruption	NOUN
dpc-5329	23	11	activates	activate	VERB
dpc-5329	23	12	a	a	DET
dpc-5329	23	13	cascade	cascade	NOUN
dpc-5329	23	14	of	of	ADP
dpc-5329	23	15	immune	immune	ADJ
dpc-5329	23	16	responses	response	NOUN
dpc-5329	23	17	.	.	PUNCT
dpc-5329	24	1	microbial	microbial	ADJ
dpc-5329	24	2	dysbiosis	dysbiosis	NOUN
dpc-5329	24	3	,	,	PUNCT
dpc-5329	24	4	in	in	ADP
dpc-5329	24	5	concert	concert	NOUN
dpc-5329	24	6	with	with	ADP
dpc-5329	24	7	the	the	DET
dpc-5329	24	8	gut	gut	NOUN
dpc-5329	24	9	-	-	PUNCT
dpc-5329	24	10	skin	skin	NOUN
dpc-5329	24	11	axis	axis	NOUN
dpc-5329	24	12	,	,	PUNCT
dpc-5329	24	13	further	far	ADV
dpc-5329	24	14	exacerbates	exacerbate	VERB
dpc-5329	24	15	ad	ad	NOUN
dpc-5329	24	16	symptoms	symptom	NOUN
dpc-5329	24	17	,	,	PUNCT
dpc-5329	24	18	highlighting	highlight	VERB
dpc-5329	24	19	how	how	SCONJ
dpc-5329	24	20	alterations	alteration	NOUN
dpc-5329	24	21	in	in	ADP
dpc-5329	24	22	one	one	NUM
dpc-5329	24	23	organ	organ	NOUN
dpc-5329	24	24	affect	affect	VERB
dpc-5329	24	25	the	the	DET
dpc-5329	24	26	other	other	ADJ
dpc-5329	24	27	.	.	PUNCT
dpc-5329	25	1	neuroinflammation	neuroinflammation	NOUN
dpc-5329	25	2	further	far	ADV
dpc-5329	25	3	contributes	contribute	VERB
dpc-5329	25	4	abstract	abstract	ADJ
dpc-5329	25	5	2	2	NUM
dpc-5329	25	6	review	review	NOUN
dpc-5329	25	7	|	|	ADV
dpc-5329	25	8	dermatol	dermatol	ADJ
dpc-5329	25	9	pract	pract	NOUN
dpc-5329	25	10	concept	concept	NOUN
dpc-5329	25	11	.	.	PUNCT
dpc-5329	26	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	26	2	introduction	introduction	NOUN
dpc-5329	26	3	atopic	atopic	NOUN
dpc-5329	26	4	dermatitis	dermatitis	NOUN
dpc-5329	26	5	(	(	PUNCT
dpc-5329	26	6	ad	ad	NOUN
dpc-5329	26	7	)	)	PUNCT
dpc-5329	26	8	is	be	AUX
dpc-5329	26	9	a	a	DET
dpc-5329	26	10	chronic	chronic	ADJ
dpc-5329	26	11	inflammatory	inflammatory	ADJ
dpc-5329	26	12	skin	skin	NOUN
dpc-5329	26	13	disease	disease	NOUN
dpc-5329	26	14	that	that	PRON
dpc-5329	26	15	presents	present	VERB
dpc-5329	26	16	as	as	ADP
dpc-5329	26	17	pruritic	pruritic	ADJ
dpc-5329	26	18	,	,	PUNCT
dpc-5329	26	19	dry	dry	ADJ
dpc-5329	26	20	,	,	PUNCT
dpc-5329	26	21	eczematous	eczematous	ADJ
dpc-5329	26	22	skin	skin	NOUN
dpc-5329	26	23	that	that	PRON
dpc-5329	26	24	is	be	AUX
dpc-5329	26	25	prevalent	prevalent	ADJ
dpc-5329	26	26	among	among	ADP
dpc-5329	26	27	10%–30	10%–30	NUM
dpc-5329	26	28	%	%	NOUN
dpc-5329	26	29	of	of	ADP
dpc-5329	26	30	children	child	NOUN
dpc-5329	26	31	and	and	CCONJ
dpc-5329	26	32	2%-10	2%-10	NUM
dpc-5329	26	33	%	%	NOUN
dpc-5329	26	34	of	of	ADP
dpc-5329	26	35	adults	adult	NOUN
dpc-5329	26	36	[	[	X
dpc-5329	26	37	1,2]1	1,2]1	NUM
dpc-5329	26	38	.	.	PUNCT
dpc-5329	27	1	the	the	DET
dpc-5329	27	2	etiology	etiology	NOUN
dpc-5329	27	3	of	of	ADP
dpc-5329	27	4	ad	ad	NOUN
dpc-5329	27	5	is	be	AUX
dpc-5329	27	6	complex	complex	ADJ
dpc-5329	27	7	,	,	PUNCT
dpc-5329	27	8	involving	involve	VERB
dpc-5329	27	9	a	a	DET
dpc-5329	27	10	combination	combination	NOUN
dpc-5329	27	11	of	of	ADP
dpc-5329	27	12	environmental	environmental	ADJ
dpc-5329	27	13	triggers	trigger	NOUN
dpc-5329	27	14	and	and	CCONJ
dpc-5329	27	15	a	a	DET
dpc-5329	27	16	genetic	genetic	ADJ
dpc-5329	27	17	predisposition	predisposition	NOUN
dpc-5329	27	18	[	[	X
dpc-5329	27	19	2	2	NUM
dpc-5329	27	20	]	]	PUNCT
dpc-5329	27	21	.	.	PUNCT
dpc-5329	28	1	the	the	DET
dpc-5329	28	2	most	most	ADV
dpc-5329	28	3	notable	notable	ADJ
dpc-5329	28	4	genetic	genetic	ADJ
dpc-5329	28	5	mutation	mutation	NOUN
dpc-5329	28	6	has	have	AUX
dpc-5329	28	7	been	be	AUX
dpc-5329	28	8	seen	see	VERB
dpc-5329	28	9	involving	involve	VERB
dpc-5329	28	10	filaggrin	filaggrin	NOUN
dpc-5329	28	11	(	(	PUNCT
dpc-5329	28	12	flg	flg	PROPN
dpc-5329	28	13	)	)	PUNCT
dpc-5329	28	14	,	,	PUNCT
dpc-5329	28	15	which	which	PRON
dpc-5329	28	16	encodes	encode	VERB
dpc-5329	28	17	an	an	DET
dpc-5329	28	18	epidermal	epidermal	ADJ
dpc-5329	28	19	protein	protein	NOUN
dpc-5329	28	20	that	that	PRON
dpc-5329	28	21	maintains	maintain	VERB
dpc-5329	28	22	skin	skin	NOUN
dpc-5329	28	23	integrity	integrity	NOUN
dpc-5329	28	24	and	and	CCONJ
dpc-5329	28	25	moisture	moisture	NOUN
dpc-5329	28	26	[	[	X
dpc-5329	28	27	2	2	NUM
dpc-5329	28	28	]	]	PUNCT
dpc-5329	28	29	.	.	PUNCT
dpc-5329	29	1	the	the	DET
dpc-5329	29	2	characteristic	characteristic	ADJ
dpc-5329	29	3	skin	skin	NOUN
dpc-5329	29	4	barrier	barrier	NOUN
dpc-5329	29	5	dysfunction	dysfunction	NOUN
dpc-5329	29	6	and	and	CCONJ
dpc-5329	29	7	immune	immune	ADJ
dpc-5329	29	8	dysregulation	dysregulation	NOUN
dpc-5329	29	9	seen	see	VERB
dpc-5329	29	10	in	in	ADP
dpc-5329	29	11	ad	ad	NOUN
dpc-5329	29	12	often	often	ADV
dpc-5329	29	13	accompanies	accompany	VERB
dpc-5329	29	14	other	other	ADJ
dpc-5329	29	15	ige	ige	NOUN
dpc-5329	29	16	-	-	PUNCT
dpc-5329	29	17	associated	associate	VERB
dpc-5329	29	18	diseases	disease	NOUN
dpc-5329	29	19	like	like	ADP
dpc-5329	29	20	asthma	asthma	NOUN
dpc-5329	29	21	and	and	CCONJ
dpc-5329	29	22	allergic	allergic	ADJ
dpc-5329	29	23	rhinitis	rhinitis	NOUN
dpc-5329	29	24	,	,	PUNCT
dpc-5329	29	25	together	together	ADV
dpc-5329	29	26	known	know	VERB
dpc-5329	29	27	as	as	ADP
dpc-5329	29	28	the	the	DET
dpc-5329	29	29	atopic	atopic	NOUN
dpc-5329	29	30	triad	triad	VERB
dpc-5329	30	1	[	[	X
dpc-5329	30	2	1,3,4	1,3,4	NUM
dpc-5329	30	3	]	]	PUNCT
dpc-5329	30	4	.	.	PUNCT
dpc-5329	31	1	recognizing	recognize	VERB
dpc-5329	31	2	this	this	DET
dpc-5329	31	3	heterogeneity	heterogeneity	NOUN
dpc-5329	31	4	is	be	AUX
dpc-5329	31	5	crucial	crucial	ADJ
dpc-5329	31	6	to	to	ADP
dpc-5329	31	7	advancing	advance	VERB
dpc-5329	31	8	precision	precision	NOUN
dpc-5329	31	9	medicine	medicine	NOUN
dpc-5329	31	10	approaches	approach	NOUN
dpc-5329	31	11	in	in	ADP
dpc-5329	31	12	ad	ad	NOUN
dpc-5329	31	13	.	.	PUNCT
dpc-5329	32	1	the	the	DET
dpc-5329	32	2	psychosocial	psychosocial	ADJ
dpc-5329	32	3	comorbidities	comorbiditie	NOUN
dpc-5329	32	4	associated	associate	VERB
dpc-5329	32	5	with	with	ADP
dpc-5329	32	6	this	this	DET
dpc-5329	32	7	disease	disease	NOUN
dpc-5329	32	8	and	and	CCONJ
dpc-5329	32	9	the	the	DET
dpc-5329	32	10	increased	increase	VERB
dpc-5329	32	11	risk	risk	NOUN
dpc-5329	32	12	of	of	ADP
dpc-5329	32	13	multisystem	multisystem	NOUN
dpc-5329	32	14	involvement	involvement	NOUN
dpc-5329	32	15	emphasizes	emphasize	VERB
dpc-5329	32	16	the	the	DET
dpc-5329	32	17	extent	extent	NOUN
dpc-5329	32	18	and	and	CCONJ
dpc-5329	32	19	burden	burden	NOUN
dpc-5329	32	20	of	of	ADP
dpc-5329	32	21	ad	ad	NOUN
dpc-5329	32	22	.	.	PUNCT
dpc-5329	33	1	[	[	X
dpc-5329	33	2	5	5	NUM
dpc-5329	33	3	]	]	PUNCT
dpc-5329	33	4	.	.	PUNCT
dpc-5329	34	1	the	the	DET
dpc-5329	34	2	multisystem	multisystem	NOUN
dpc-5329	34	3	impact	impact	NOUN
dpc-5329	34	4	of	of	ADP
dpc-5329	34	5	ad	ad	NOUN
dpc-5329	34	6	is	be	AUX
dpc-5329	34	7	intricately	intricately	ADV
dpc-5329	34	8	linked	link	VERB
dpc-5329	34	9	to	to	ADP
dpc-5329	34	10	both	both	CCONJ
dpc-5329	34	11	the	the	DET
dpc-5329	34	12	neuro	neuro	PROPN
dpc-5329	34	13	-	-	PUNCT
dpc-5329	34	14	immuno	immuno	ADJ
dpc-5329	34	15	-	-	ADJ
dpc-5329	34	16	cutaneous	cutaneous	ADJ
dpc-5329	34	17	-	-	PUNCT
dpc-5329	34	18	endocrine	endocrine	ADJ
dpc-5329	34	19	(	(	PUNCT
dpc-5329	34	20	nice	nice	ADJ
dpc-5329	34	21	)	)	PUNCT
dpc-5329	34	22	network	network	NOUN
dpc-5329	34	23	and	and	CCONJ
dpc-5329	34	24	the	the	DET
dpc-5329	34	25	gut	gut	NOUN
dpc-5329	34	26	-	-	PUNCT
dpc-5329	34	27	skin	skin	NOUN
dpc-5329	34	28	axis	axis	NOUN
dpc-5329	34	29	,	,	PUNCT
dpc-5329	34	30	offering	offer	VERB
dpc-5329	34	31	insight	insight	NOUN
dpc-5329	34	32	into	into	ADP
dpc-5329	34	33	the	the	DET
dpc-5329	34	34	complex	complex	ADJ
dpc-5329	34	35	pathophysiology	pathophysiology	NOUN
dpc-5329	34	36	of	of	ADP
dpc-5329	34	37	the	the	DET
dpc-5329	34	38	disease	disease	NOUN
dpc-5329	34	39	.	.	PUNCT
dpc-5329	35	1	neuropeptides	neuropeptide	NOUN
dpc-5329	35	2	like	like	ADP
dpc-5329	35	3	calcitonin	calcitonin	ADJ
dpc-5329	35	4	gene	gene	NOUN
dpc-5329	35	5	-	-	PUNCT
dpc-5329	35	6	related	relate	VERB
dpc-5329	35	7	peptide	peptide	NOUN
dpc-5329	35	8	(	(	PUNCT
dpc-5329	35	9	cgrp	cgrp	PROPN
dpc-5329	35	10	)	)	PUNCT
dpc-5329	35	11	,	,	PUNCT
dpc-5329	35	12	substance	substance	NOUN
dpc-5329	35	13	p	p	NOUN
dpc-5329	35	14	,	,	PUNCT
dpc-5329	35	15	and	and	CCONJ
dpc-5329	35	16	vasoactive	vasoactive	ADJ
dpc-5329	35	17	intestinal	intestinal	ADJ
dpc-5329	35	18	peptide	peptide	NOUN
dpc-5329	35	19	(	(	PUNCT
dpc-5329	35	20	vip	vip	NOUN
dpc-5329	35	21	)	)	PUNCT
dpc-5329	35	22	promote	promote	VERB
dpc-5329	35	23	inflammation	inflammation	NOUN
dpc-5329	35	24	via	via	ADP
dpc-5329	35	25	cutaneous	cutaneous	ADJ
dpc-5329	35	26	nerves	nerve	NOUN
dpc-5329	35	27	.	.	PUNCT
dpc-5329	36	1	neuroendocrine	neuroendocrine	ADJ
dpc-5329	36	2	mediators	mediator	NOUN
dpc-5329	36	3	,	,	PUNCT
dpc-5329	36	4	including	include	VERB
dpc-5329	36	5	glucocorticoids	glucocorticoid	NOUN
dpc-5329	36	6	,	,	PUNCT
dpc-5329	36	7	are	be	AUX
dpc-5329	36	8	produced	produce	VERB
dpc-5329	36	9	in	in	ADP
dpc-5329	36	10	response	response	NOUN
dpc-5329	36	11	to	to	ADP
dpc-5329	36	12	stress	stress	NOUN
dpc-5329	36	13	and	and	CCONJ
dpc-5329	36	14	activate	activate	VERB
dpc-5329	36	15	the	the	DET
dpc-5329	36	16	hypothalamic	hypothalamic	ADJ
dpc-5329	36	17	-	-	PUNCT
dpc-5329	36	18	pituitary	pituitary	ADJ
dpc-5329	36	19	-	-	PUNCT
dpc-5329	36	20	adrenal	adrenal	ADJ
dpc-5329	36	21	(	(	PUNCT
dpc-5329	36	22	hpa	hpa	NOUN
dpc-5329	36	23	)	)	PUNCT
dpc-5329	36	24	axis	axis	NOUN
dpc-5329	36	25	and	and	CCONJ
dpc-5329	36	26	subsequent	subsequent	ADJ
dpc-5329	36	27	hormonal	hormonal	ADJ
dpc-5329	36	28	cascades	cascade	NOUN
dpc-5329	37	1	[	[	X
dpc-5329	37	2	6	6	NUM
dpc-5329	37	3	]	]	PUNCT
dpc-5329	37	4	.	.	PUNCT
dpc-5329	38	1	furthermore	furthermore	ADV
dpc-5329	38	2	,	,	PUNCT
dpc-5329	38	3	overactivation	overactivation	NOUN
dpc-5329	38	4	of	of	ADP
dpc-5329	38	5	the	the	DET
dpc-5329	38	6	th2	th2	PROPN
dpc-5329	38	7	immune	immune	ADJ
dpc-5329	38	8	response	response	NOUN
dpc-5329	38	9	increases	increase	VERB
dpc-5329	38	10	levels	level	NOUN
dpc-5329	38	11	of	of	ADP
dpc-5329	38	12	il-4	il-4	NOUN
dpc-5329	38	13	and	and	CCONJ
dpc-5329	38	14	il-13	il-13	ADP
dpc-5329	38	15	during	during	ADP
dpc-5329	38	16	disease	disease	NOUN
dpc-5329	38	17	flares	flare	NOUN
dpc-5329	38	18	(	(	PUNCT
dpc-5329	38	19	figure	figure	NOUN
dpc-5329	38	20	1	1	NUM
dpc-5329	38	21	)	)	PUNCT
dpc-5329	39	1	[	[	X
dpc-5329	39	2	7	7	NUM
dpc-5329	39	3	]	]	PUNCT
dpc-5329	39	4	.	.	PUNCT
dpc-5329	40	1	additionally	additionally	ADV
dpc-5329	40	2	,	,	PUNCT
dpc-5329	40	3	gut	gut	NOUN
dpc-5329	40	4	dysbiosis	dysbiosis	NOUN
dpc-5329	40	5	,	,	PUNCT
dpc-5329	40	6	increased	increase	VERB
dpc-5329	40	7	intestinal	intestinal	ADJ
dpc-5329	40	8	permeability	permeability	NOUN
dpc-5329	40	9	,	,	PUNCT
dpc-5329	40	10	and	and	CCONJ
dpc-5329	40	11	changes	change	NOUN
dpc-5329	40	12	in	in	ADP
dpc-5329	40	13	microbial	microbial	ADJ
dpc-5329	40	14	metabolic	metabolic	NOUN
dpc-5329	40	15	byproducts	byproduct	NOUN
dpc-5329	40	16	exacerbate	exacerbate	VERB
dpc-5329	40	17	systemic	systemic	ADJ
dpc-5329	40	18	inflammation	inflammation	NOUN
dpc-5329	40	19	,	,	PUNCT
dpc-5329	40	20	intensifying	intensify	VERB
dpc-5329	40	21	the	the	DET
dpc-5329	40	22	hallmark	hallmark	ADJ
dpc-5329	40	23	itch	itch	NOUN
dpc-5329	40	24	-	-	PUNCT
dpc-5329	40	25	scratch	scratch	NOUN
dpc-5329	40	26	cycle	cycle	NOUN
dpc-5329	40	27	through	through	ADP
dpc-5329	40	28	neural	neural	ADJ
dpc-5329	40	29	and	and	CCONJ
dpc-5329	40	30	immune	immune	ADJ
dpc-5329	40	31	systems	system	NOUN
dpc-5329	40	32	[	[	X
dpc-5329	40	33	8	8	NUM
dpc-5329	40	34	]	]	PUNCT
dpc-5329	40	35	.	.	PUNCT
dpc-5329	41	1	collectively	collectively	ADV
dpc-5329	41	2	,	,	PUNCT
dpc-5329	41	3	these	these	DET
dpc-5329	41	4	interconnected	interconnect	VERB
dpc-5329	41	5	systems	system	NOUN
dpc-5329	41	6	contribute	contribute	VERB
dpc-5329	41	7	to	to	ADP
dpc-5329	41	8	the	the	DET
dpc-5329	41	9	multifaceted	multifaceted	ADJ
dpc-5329	41	10	nature	nature	NOUN
dpc-5329	41	11	of	of	ADP
dpc-5329	41	12	ad	ad	NOUN
dpc-5329	41	13	pathology	pathology	NOUN
dpc-5329	41	14	[	[	X
dpc-5329	41	15	9	9	NUM
dpc-5329	41	16	]	]	PUNCT
dpc-5329	41	17	.	.	PUNCT
dpc-5329	42	1	in	in	ADP
dpc-5329	42	2	addition	addition	NOUN
dpc-5329	42	3	to	to	ADP
dpc-5329	42	4	its	its	PRON
dpc-5329	42	5	systemic	systemic	ADJ
dpc-5329	42	6	impact	impact	NOUN
dpc-5329	42	7	,	,	PUNCT
dpc-5329	42	8	ad	ad	NOUN
dpc-5329	42	9	is	be	AUX
dpc-5329	42	10	a	a	DET
dpc-5329	42	11	highly	highly	ADV
dpc-5329	42	12	heterogeneous	heterogeneous	ADJ
dpc-5329	42	13	disease	disease	NOUN
dpc-5329	42	14	,	,	PUNCT
dpc-5329	42	15	exhibiting	exhibit	VERB
dpc-5329	42	16	variability	variability	NOUN
dpc-5329	42	17	in	in	ADP
dpc-5329	42	18	clinical	clinical	ADJ
dpc-5329	42	19	presentation	presentation	NOUN
dpc-5329	42	20	,	,	PUNCT
dpc-5329	42	21	pathophysiology	pathophysiology	NOUN
dpc-5329	42	22	,	,	PUNCT
dpc-5329	42	23	and	and	CCONJ
dpc-5329	42	24	treatment	treatment	NOUN
dpc-5329	42	25	response	response	NOUN
dpc-5329	42	26	.	.	PUNCT
dpc-5329	43	1	while	while	SCONJ
dpc-5329	43	2	inflammation	inflammation	NOUN
dpc-5329	43	3	in	in	ADP
dpc-5329	43	4	ad	ad	NOUN
dpc-5329	43	5	is	be	AUX
dpc-5329	43	6	primarily	primarily	ADV
dpc-5329	43	7	driven	drive	VERB
dpc-5329	43	8	by	by	ADP
dpc-5329	43	9	the	the	DET
dpc-5329	43	10	th2	th2	PROPN
dpc-5329	43	11	mechanism	mechanism	NOUN
dpc-5329	43	12	,	,	PUNCT
dpc-5329	43	13	recent	recent	ADJ
dpc-5329	43	14	studies	study	NOUN
dpc-5329	43	15	have	have	AUX
dpc-5329	43	16	found	find	VERB
dpc-5329	43	17	th1	th1	PROPN
dpc-5329	43	18	,	,	PUNCT
dpc-5329	43	19	th17	th17	PROPN
dpc-5329	43	20	,	,	PUNCT
dpc-5329	43	21	and	and	CCONJ
dpc-5329	43	22	th22	th22	PROPN
dpc-5329	43	23	pathways	pathway	NOUN
dpc-5329	43	24	implicated	implicate	VERB
dpc-5329	43	25	in	in	ADP
dpc-5329	43	26	some	some	DET
dpc-5329	43	27	populations	population	NOUN
dpc-5329	43	28	as	as	ADV
dpc-5329	43	29	well	well	ADV
dpc-5329	43	30	[	[	X
dpc-5329	43	31	10,11	10,11	NOUN
dpc-5329	43	32	]	]	X
dpc-5329	43	33	.	.	PUNCT
dpc-5329	44	1	moreover	moreover	ADV
dpc-5329	44	2	,	,	PUNCT
dpc-5329	44	3	the	the	DET
dpc-5329	44	4	classification	classification	NOUN
dpc-5329	44	5	of	of	ADP
dpc-5329	44	6	intrinsic	intrinsic	ADJ
dpc-5329	44	7	and	and	CCONJ
dpc-5329	44	8	extrinsic	extrinsic	ADJ
dpc-5329	44	9	ad	ad	NOUN
dpc-5329	44	10	phenotypes	phenotype	NOUN
dpc-5329	44	11	further	far	ADV
dpc-5329	44	12	highlights	highlight	VERB
dpc-5329	44	13	the	the	DET
dpc-5329	44	14	disease	disease	NOUN
dpc-5329	44	15	variability	variability	NOUN
dpc-5329	44	16	,	,	PUNCT
dpc-5329	44	17	with	with	ADP
dpc-5329	44	18	the	the	DET
dpc-5329	44	19	two	two	NUM
dpc-5329	44	20	phenotypes	phenotype	NOUN
dpc-5329	44	21	differing	differ	VERB
dpc-5329	44	22	in	in	ADP
dpc-5329	44	23	their	their	PRON
dpc-5329	44	24	ige	ige	PROPN
dpc-5329	44	25	levels	level	NOUN
dpc-5329	44	26	,	,	PUNCT
dpc-5329	44	27	epidermal	epidermal	ADJ
dpc-5329	44	28	barrier	barrier	NOUN
dpc-5329	44	29	dysfunction	dysfunction	NOUN
dpc-5329	44	30	,	,	PUNCT
dpc-5329	44	31	and	and	CCONJ
dpc-5329	44	32	immune	immune	ADJ
dpc-5329	44	33	activation	activation	NOUN
dpc-5329	44	34	pathophysiology	pathophysiology	NOUN
dpc-5329	44	35	[	[	X
dpc-5329	44	36	11,12	11,12	NOUN
dpc-5329	44	37	]	]	PUNCT
dpc-5329	44	38	.	.	PUNCT
dpc-5329	45	1	appreciating	appreciate	VERB
dpc-5329	45	2	the	the	DET
dpc-5329	45	3	heterogeneity	heterogeneity	NOUN
dpc-5329	45	4	of	of	ADP
dpc-5329	45	5	ad	ad	NOUN
dpc-5329	45	6	is	be	AUX
dpc-5329	45	7	essential	essential	ADJ
dpc-5329	45	8	to	to	ADP
dpc-5329	45	9	advancing	advance	VERB
dpc-5329	45	10	individualized	individualized	ADJ
dpc-5329	45	11	and	and	CCONJ
dpc-5329	45	12	comprehensive	comprehensive	ADJ
dpc-5329	45	13	treatment	treatment	NOUN
dpc-5329	45	14	approaches	approach	NOUN
dpc-5329	45	15	.	.	PUNCT
dpc-5329	46	1	objective	objective	ADJ
dpc-5329	46	2	this	this	DET
dpc-5329	46	3	paper	paper	NOUN
dpc-5329	46	4	proposes	propose	VERB
dpc-5329	46	5	the	the	DET
dpc-5329	46	6	skin	skin	NOUN
dpc-5329	46	7	-	-	PUNCT
dpc-5329	46	8	immune	immune	NOUN
dpc-5329	46	9	-	-	PUNCT
dpc-5329	46	10	neuro	neuro	NOUN
dpc-5329	46	11	-	-	PUNCT
dpc-5329	46	12	gastro	gastro	ADJ
dpc-5329	46	13	endocrine	endocrine	NOUN
dpc-5329	46	14	(	(	PUNCT
dpc-5329	46	15	singe	singe	NOUN
dpc-5329	46	16	)	)	PUNCT
dpc-5329	46	17	network	network	NOUN
dpc-5329	46	18	as	as	ADP
dpc-5329	46	19	a	a	DET
dpc-5329	46	20	framework	framework	NOUN
dpc-5329	46	21	to	to	PART
dpc-5329	46	22	investigate	investigate	VERB
dpc-5329	46	23	the	the	DET
dpc-5329	46	24	multisystem	multisystem	NOUN
dpc-5329	46	25	contributions	contribution	NOUN
dpc-5329	46	26	of	of	ADP
dpc-5329	46	27	ad	ad	NOUN
dpc-5329	46	28	.	.	PUNCT
dpc-5329	47	1	by	by	ADP
dpc-5329	47	2	encapsulating	encapsulate	VERB
dpc-5329	47	3	the	the	DET
dpc-5329	47	4	intricate	intricate	ADJ
dpc-5329	47	5	connections	connection	NOUN
dpc-5329	47	6	between	between	ADP
dpc-5329	47	7	the	the	DET
dpc-5329	47	8	systems	system	NOUN
dpc-5329	47	9	,	,	PUNCT
dpc-5329	47	10	this	this	DET
dpc-5329	47	11	study	study	NOUN
dpc-5329	47	12	aimed	aim	VERB
dpc-5329	47	13	to	to	PART
dpc-5329	47	14	explore	explore	VERB
dpc-5329	47	15	biomarkers	biomarker	NOUN
dpc-5329	47	16	and	and	CCONJ
dpc-5329	47	17	pathways	pathway	NOUN
dpc-5329	47	18	involved	involve	VERB
dpc-5329	47	19	in	in	ADP
dpc-5329	47	20	the	the	DET
dpc-5329	47	21	disease	disease	NOUN
dpc-5329	47	22	pathogenesis	pathogenesis	NOUN
dpc-5329	47	23	in	in	ADP
dpc-5329	47	24	hopes	hope	NOUN
dpc-5329	47	25	of	of	ADP
dpc-5329	47	26	laying	lay	VERB
dpc-5329	47	27	the	the	DET
dpc-5329	47	28	foundation	foundation	NOUN
dpc-5329	47	29	for	for	ADP
dpc-5329	47	30	future	future	ADJ
dpc-5329	47	31	targeted	target	VERB
dpc-5329	47	32	treatments	treatment	NOUN
dpc-5329	47	33	and	and	CCONJ
dpc-5329	47	34	ultimately	ultimately	ADV
dpc-5329	47	35	enhancing	enhance	VERB
dpc-5329	47	36	patient	patient	ADJ
dpc-5329	47	37	care	care	NOUN
dpc-5329	47	38	(	(	PUNCT
dpc-5329	47	39	figure	figure	NOUN
dpc-5329	47	40	2	2	NUM
dpc-5329	47	41	)	)	PUNCT
dpc-5329	47	42	.	.	PUNCT
dpc-5329	48	1	singe	singe	NOUN
dpc-5329	48	2	versus	versus	ADP
dpc-5329	48	3	nice	nice	ADJ
dpc-5329	48	4	systems	system	NOUN
dpc-5329	48	5	while	while	SCONJ
dpc-5329	48	6	the	the	DET
dpc-5329	48	7	two	two	NUM
dpc-5329	48	8	systems	system	NOUN
dpc-5329	48	9	have	have	VERB
dpc-5329	48	10	great	great	ADJ
dpc-5329	48	11	overlap	overlap	NOUN
dpc-5329	48	12	,	,	PUNCT
dpc-5329	48	13	they	they	PRON
dpc-5329	48	14	propose	propose	VERB
dpc-5329	48	15	distinct	distinct	ADJ
dpc-5329	48	16	approaches	approach	NOUN
dpc-5329	48	17	to	to	ADP
dpc-5329	48	18	understanding	understand	VERB
dpc-5329	48	19	cutaneous	cutaneous	ADJ
dpc-5329	48	20	disorders	disorder	NOUN
dpc-5329	48	21	.	.	PUNCT
dpc-5329	49	1	the	the	DET
dpc-5329	49	2	nice	nice	ADJ
dpc-5329	49	3	network	network	NOUN
dpc-5329	49	4	primarily	primarily	ADV
dpc-5329	49	5	highlights	highlight	VERB
dpc-5329	49	6	the	the	DET
dpc-5329	49	7	bidirectional	bidirectional	ADJ
dpc-5329	49	8	crosstalk	crosstalk	NOUN
dpc-5329	49	9	between	between	ADP
dpc-5329	49	10	the	the	DET
dpc-5329	49	11	skin	skin	NOUN
dpc-5329	49	12	,	,	PUNCT
dpc-5329	49	13	immune	immune	ADJ
dpc-5329	49	14	system	system	NOUN
dpc-5329	49	15	,	,	PUNCT
dpc-5329	49	16	nervous	nervous	ADJ
dpc-5329	49	17	system	system	NOUN
dpc-5329	49	18	,	,	PUNCT
dpc-5329	49	19	and	and	CCONJ
dpc-5329	49	20	endocrine	endocrine	ADJ
dpc-5329	49	21	pathways	pathway	NOUN
dpc-5329	49	22	.	.	PUNCT
dpc-5329	50	1	it	it	PRON
dpc-5329	50	2	emphasizes	emphasize	VERB
dpc-5329	50	3	how	how	SCONJ
dpc-5329	50	4	stress	stress	NOUN
dpc-5329	50	5	-	-	PUNCT
dpc-5329	50	6	induced	induce	VERB
dpc-5329	50	7	neuroendocrine	neuroendocrine	NOUN
dpc-5329	50	8	signaling	signal	VERB
dpc-5329	50	9	exacerbates	exacerbate	NOUN
dpc-5329	50	10	immune	immune	NOUN
dpc-5329	50	11	-	-	PUNCT
dpc-5329	50	12	mediated	mediate	VERB
dpc-5329	50	13	cutaneous	cutaneous	ADJ
dpc-5329	50	14	inflammation	inflammation	NOUN
dpc-5329	50	15	.	.	PUNCT
dpc-5329	51	1	although	although	SCONJ
dpc-5329	51	2	the	the	DET
dpc-5329	51	3	nice	nice	ADJ
dpc-5329	51	4	system	system	NOUN
dpc-5329	51	5	takes	take	VERB
dpc-5329	51	6	stress	stress	NOUN
dpc-5329	51	7	responses	response	NOUN
dpc-5329	51	8	into	into	ADP
dpc-5329	51	9	account	account	NOUN
dpc-5329	51	10	,	,	PUNCT
dpc-5329	51	11	it	it	PRON
dpc-5329	51	12	does	do	AUX
dpc-5329	51	13	not	not	PART
dpc-5329	51	14	explicitly	explicitly	ADV
dpc-5329	51	15	integrate	integrate	VERB
dpc-5329	51	16	the	the	DET
dpc-5329	51	17	crucial	crucial	ADJ
dpc-5329	51	18	role	role	NOUN
dpc-5329	51	19	of	of	ADP
dpc-5329	51	20	the	the	DET
dpc-5329	51	21	gastrointestinal	gastrointestinal	ADJ
dpc-5329	51	22	(	(	PUNCT
dpc-5329	51	23	gi	gi	NOUN
dpc-5329	51	24	)	)	PUNCT
dpc-5329	51	25	system	system	NOUN
dpc-5329	51	26	,	,	PUNCT
dpc-5329	51	27	which	which	PRON
dpc-5329	51	28	has	have	AUX
dpc-5329	51	29	emerged	emerge	VERB
dpc-5329	51	30	as	as	ADP
dpc-5329	51	31	a	a	DET
dpc-5329	51	32	key	key	ADJ
dpc-5329	51	33	contributor	contributor	NOUN
dpc-5329	51	34	to	to	ADP
dpc-5329	51	35	systemic	systemic	ADJ
dpc-5329	51	36	immune	immune	ADJ
dpc-5329	51	37	and	and	CCONJ
dpc-5329	51	38	inflammatory	inflammatory	ADJ
dpc-5329	51	39	pathways	pathway	NOUN
dpc-5329	51	40	.	.	PUNCT
dpc-5329	52	1	the	the	DET
dpc-5329	52	2	singe	singe	PROPN
dpc-5329	52	3	network	network	NOUN
dpc-5329	52	4	builds	build	VERB
dpc-5329	52	5	upon	upon	SCONJ
dpc-5329	52	6	the	the	DET
dpc-5329	52	7	nice	nice	ADJ
dpc-5329	52	8	framework	framework	NOUN
dpc-5329	52	9	by	by	ADP
dpc-5329	52	10	integrating	integrate	VERB
dpc-5329	52	11	the	the	DET
dpc-5329	52	12	gi	gi	PROPN
dpc-5329	52	13	contributions	contribution	NOUN
dpc-5329	52	14	to	to	ADP
dpc-5329	52	15	systemic	systemic	ADJ
dpc-5329	52	16	inflammation	inflammation	NOUN
dpc-5329	52	17	and	and	CCONJ
dpc-5329	52	18	immune	immune	ADJ
dpc-5329	52	19	responses	response	NOUN
dpc-5329	52	20	in	in	ADP
dpc-5329	52	21	ad	ad	NOUN
dpc-5329	52	22	.	.	PUNCT
dpc-5329	53	1	this	this	DET
dpc-5329	53	2	addition	addition	NOUN
dpc-5329	53	3	accounts	account	VERB
dpc-5329	53	4	for	for	ADP
dpc-5329	53	5	the	the	DET
dpc-5329	53	6	roles	role	NOUN
dpc-5329	53	7	of	of	ADP
dpc-5329	53	8	the	the	DET
dpc-5329	53	9	gut	gut	NOUN
dpc-5329	53	10	microbiome	microbiome	NOUN
dpc-5329	53	11	and	and	CCONJ
dpc-5329	53	12	the	the	DET
dpc-5329	53	13	epithelial	epithelial	ADJ
dpc-5329	53	14	barrier	barrier	NOUN
dpc-5329	53	15	dysfunction	dysfunction	NOUN
dpc-5329	53	16	,	,	PUNCT
dpc-5329	53	17	both	both	DET
dpc-5329	53	18	skin	skin	NOUN
dpc-5329	53	19	and	and	CCONJ
dpc-5329	53	20	intestinal	intestinal	ADJ
dpc-5329	53	21	,	,	PUNCT
dpc-5329	53	22	that	that	PRON
dpc-5329	53	23	contribute	contribute	VERB
dpc-5329	53	24	neuroendocrine	neuroendocrine	NOUN
dpc-5329	53	25	signaling	signaling	ADJ
dpc-5329	53	26	and	and	CCONJ
dpc-5329	53	27	immune	immune	ADJ
dpc-5329	53	28	responses	response	NOUN
dpc-5329	53	29	[	[	X
dpc-5329	53	30	27,28	27,28	NOUN
dpc-5329	53	31	]	]	X
dpc-5329	53	32	.	.	PUNCT
dpc-5329	54	1	as	as	ADP
dpc-5329	54	2	such	such	ADJ
dpc-5329	54	3	,	,	PUNCT
dpc-5329	54	4	the	the	DET
dpc-5329	54	5	singe	singe	NOUN
dpc-5329	54	6	system	system	NOUN
dpc-5329	54	7	lays	lay	VERB
dpc-5329	54	8	the	the	DET
dpc-5329	54	9	foundation	foundation	NOUN
dpc-5329	54	10	for	for	ADP
dpc-5329	54	11	a	a	DET
dpc-5329	54	12	more	more	ADV
dpc-5329	54	13	comprehensive	comprehensive	ADJ
dpc-5329	54	14	framework	framework	NOUN
dpc-5329	54	15	for	for	ADP
dpc-5329	54	16	understanding	understand	VERB
dpc-5329	54	17	ad	ad	NOUN
dpc-5329	54	18	.	.	PUNCT
dpc-5329	55	1	to	to	ADP
dpc-5329	55	2	ad	ad	NOUN
dpc-5329	55	3	symptoms	symptom	NOUN
dpc-5329	55	4	by	by	ADP
dpc-5329	55	5	perpetuating	perpetuate	VERB
dpc-5329	55	6	the	the	DET
dpc-5329	55	7	itch	itch	NOUN
dpc-5329	55	8	-	-	PUNCT
dpc-5329	55	9	scratch	scratch	NOUN
dpc-5329	55	10	cycle	cycle	NOUN
dpc-5329	55	11	.	.	PUNCT
dpc-5329	56	1	neuroendocrine	neuroendocrine	ADJ
dpc-5329	56	2	factors	factor	NOUN
dpc-5329	56	3	amplify	amplify	VERB
dpc-5329	56	4	the	the	DET
dpc-5329	56	5	inflammatory	inflammatory	ADJ
dpc-5329	56	6	dysregulation	dysregulation	NOUN
dpc-5329	56	7	,	,	PUNCT
dpc-5329	56	8	particularly	particularly	ADV
dpc-5329	56	9	through	through	ADP
dpc-5329	56	10	endocrine	endocrine	ADJ
dpc-5329	56	11	involvement	involvement	NOUN
dpc-5329	56	12	involving	involve	VERB
dpc-5329	56	13	cortisol	cortisol	NOUN
dpc-5329	56	14	signaling	signal	VERB
dpc-5329	56	15	in	in	ADP
dpc-5329	56	16	the	the	DET
dpc-5329	56	17	hypothalamic	hypothalamic	ADJ
dpc-5329	56	18	-	-	PUNCT
dpc-5329	56	19	pituitary	pituitary	ADJ
dpc-5329	56	20	-	-	PUNCT
dpc-5329	56	21	adrenal	adrenal	ADJ
dpc-5329	56	22	(	(	PUNCT
dpc-5329	56	23	hpa	hpa	NOUN
dpc-5329	56	24	)	)	PUNCT
dpc-5329	56	25	axis	axis	NOUN
dpc-5329	56	26	and	and	CCONJ
dpc-5329	56	27	the	the	DET
dpc-5329	56	28	paradoxical	paradoxical	ADJ
dpc-5329	56	29	inflammatory	inflammatory	ADJ
dpc-5329	56	30	effects	effect	NOUN
dpc-5329	56	31	on	on	ADP
dpc-5329	56	32	the	the	DET
dpc-5329	56	33	skin	skin	NOUN
dpc-5329	56	34	barrier	barrier	NOUN
dpc-5329	56	35	.	.	PUNCT
dpc-5329	57	1	together	together	ADV
dpc-5329	57	2	,	,	PUNCT
dpc-5329	57	3	these	these	DET
dpc-5329	57	4	intertwined	intertwine	VERB
dpc-5329	57	5	pathways	pathway	NOUN
dpc-5329	57	6	perpetuate	perpetuate	VERB
dpc-5329	57	7	the	the	DET
dpc-5329	57	8	chronic	chronic	ADJ
dpc-5329	57	9	inflammation	inflammation	NOUN
dpc-5329	57	10	and	and	CCONJ
dpc-5329	57	11	skin	skin	NOUN
dpc-5329	57	12	barrier	barrier	NOUN
dpc-5329	57	13	dysfunction	dysfunction	NOUN
dpc-5329	57	14	in	in	ADP
dpc-5329	57	15	ad	ad	NOUN
dpc-5329	57	16	.	.	PUNCT
dpc-5329	58	1	conclusion	conclusion	NOUN
dpc-5329	58	2	:	:	PUNCT
dpc-5329	58	3	by	by	ADP
dpc-5329	58	4	examining	examine	VERB
dpc-5329	58	5	these	these	DET
dpc-5329	58	6	elements	element	NOUN
dpc-5329	58	7	as	as	ADP
dpc-5329	58	8	an	an	DET
dpc-5329	58	9	intricate	intricate	ADJ
dpc-5329	58	10	,	,	PUNCT
dpc-5329	58	11	intertwined	intertwine	VERB
dpc-5329	58	12	system	system	NOUN
dpc-5329	58	13	,	,	PUNCT
dpc-5329	58	14	the	the	DET
dpc-5329	58	15	singe	singe	NOUN
dpc-5329	58	16	network	network	NOUN
dpc-5329	58	17	reframes	reframe	VERB
dpc-5329	58	18	ad	ad	NOUN
dpc-5329	58	19	as	as	ADP
dpc-5329	58	20	a	a	DET
dpc-5329	58	21	multisystem	multisystem	NOUN
dpc-5329	58	22	condition	condition	NOUN
dpc-5329	58	23	.	.	PUNCT
dpc-5329	59	1	this	this	DET
dpc-5329	59	2	apprach	apprach	VERB
dpc-5329	59	3	not	not	PART
dpc-5329	59	4	only	only	ADV
dpc-5329	59	5	shifts	shift	NOUN
dpc-5329	59	6	the	the	DET
dpc-5329	59	7	understanding	understanding	NOUN
dpc-5329	59	8	of	of	ADP
dpc-5329	59	9	the	the	DET
dpc-5329	59	10	disease	disease	NOUN
dpc-5329	59	11	,	,	PUNCT
dpc-5329	59	12	but	but	CCONJ
dpc-5329	59	13	also	also	ADV
dpc-5329	59	14	serves	serve	VERB
dpc-5329	59	15	as	as	ADP
dpc-5329	59	16	a	a	DET
dpc-5329	59	17	foundation	foundation	NOUN
dpc-5329	59	18	for	for	ADP
dpc-5329	59	19	exploration	exploration	NOUN
dpc-5329	59	20	of	of	ADP
dpc-5329	59	21	targeted	target	VERB
dpc-5329	59	22	therapies	therapy	NOUN
dpc-5329	59	23	.	.	PUNCT
dpc-5329	60	1	review	review	VERB
dpc-5329	60	2	|	|	ADV
dpc-5329	60	3	dermatol	dermatol	ADJ
dpc-5329	60	4	pract	pract	NOUN
dpc-5329	60	5	concept	concept	NOUN
dpc-5329	60	6	.	.	PUNCT
dpc-5329	61	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	61	2	3	3	NUM
dpc-5329	61	3	immune	immune	ADJ
dpc-5329	61	4	involvement	involvement	NOUN
dpc-5329	61	5	in	in	ADP
dpc-5329	61	6	ad	ad	NOUN
dpc-5329	61	7	the	the	DET
dpc-5329	61	8	epithelia	epithelium	NOUN
dpc-5329	61	9	serve	serve	VERB
dpc-5329	61	10	as	as	ADP
dpc-5329	61	11	the	the	DET
dpc-5329	61	12	first	first	ADJ
dpc-5329	61	13	line	line	NOUN
dpc-5329	61	14	of	of	ADP
dpc-5329	61	15	defense	defense	NOUN
dpc-5329	61	16	in	in	ADP
dpc-5329	61	17	the	the	DET
dpc-5329	61	18	immune	immune	ADJ
dpc-5329	61	19	system	system	NOUN
dpc-5329	61	20	through	through	ADP
dpc-5329	61	21	their	their	PRON
dpc-5329	61	22	physical	physical	ADJ
dpc-5329	61	23	barrier	barrier	NOUN
dpc-5329	61	24	function	function	NOUN
dpc-5329	61	25	.	.	PUNCT
dpc-5329	62	1	keratinocytes	keratinocyte	NOUN
dpc-5329	62	2	in	in	ADP
dpc-5329	62	3	the	the	DET
dpc-5329	62	4	epidermis	epidermis	NOUN
dpc-5329	62	5	play	play	VERB
dpc-5329	62	6	a	a	DET
dpc-5329	62	7	key	key	ADJ
dpc-5329	62	8	role	role	NOUN
dpc-5329	62	9	in	in	ADP
dpc-5329	62	10	maintaining	maintain	VERB
dpc-5329	62	11	barrier	barrier	NOUN
dpc-5329	62	12	integrity	integrity	NOUN
dpc-5329	62	13	through	through	ADP
dpc-5329	62	14	tight	tight	ADJ
dpc-5329	62	15	junctions	junction	NOUN
dpc-5329	62	16	and	and	CCONJ
dpc-5329	62	17	flg	flg	PROPN
dpc-5329	62	18	production	production	NOUN
dpc-5329	62	19	[	[	X
dpc-5329	62	20	10	10	NUM
dpc-5329	62	21	]	]	PUNCT
dpc-5329	62	22	.	.	PUNCT
dpc-5329	63	1	additionally	additionally	ADV
dpc-5329	63	2	,	,	PUNCT
dpc-5329	63	3	these	these	DET
dpc-5329	63	4	cells	cell	NOUN
dpc-5329	63	5	engage	engage	VERB
dpc-5329	63	6	the	the	DET
dpc-5329	63	7	immune	immune	ADJ
dpc-5329	63	8	system	system	NOUN
dpc-5329	63	9	by	by	ADP
dpc-5329	63	10	generating	generate	VERB
dpc-5329	63	11	cytokines	cytokine	NOUN
dpc-5329	63	12	,	,	PUNCT
dpc-5329	63	13	signaling	signal	VERB
dpc-5329	63	14	through	through	ADP
dpc-5329	63	15	major	major	ADJ
dpc-5329	63	16	histocompatibility	histocompatibility	NOUN
dpc-5329	63	17	complex	complex	NOUN
dpc-5329	63	18	(	(	PUNCT
dpc-5329	63	19	mhc	mhc	PROPN
dpc-5329	63	20	)	)	PUNCT
dpc-5329	63	21	class	class	NOUN
dpc-5329	63	22	i	i	PROPN
dpc-5329	63	23	and	and	CCONJ
dpc-5329	63	24	ii	ii	NUM
dpc-5329	63	25	proteins	protein	NOUN
dpc-5329	63	26	and	and	CCONJ
dpc-5329	63	27	producing	produce	VERB
dpc-5329	63	28	antimicrobial	antimicrobial	ADJ
dpc-5329	63	29	peptides	peptide	NOUN
dpc-5329	63	30	like	like	ADP
dpc-5329	63	31	cathelicidins	cathelicidin	NOUN
dpc-5329	63	32	and	and	CCONJ
dpc-5329	63	33	defensins	defensin	NOUN
dpc-5329	63	34	.	.	PUNCT
dpc-5329	64	1	toll	toll	NOUN
dpc-5329	64	2	-	-	PUNCT
dpc-5329	64	3	like	like	ADJ
dpc-5329	64	4	receptors	receptor	NOUN
dpc-5329	64	5	(	(	PUNCT
dpc-5329	64	6	tlrs	tlrs	NOUN
dpc-5329	64	7	)	)	PUNCT
dpc-5329	64	8	on	on	ADP
dpc-5329	64	9	keratinocytes	keratinocyte	NOUN
dpc-5329	64	10	interact	interact	VERB
dpc-5329	64	11	with	with	ADP
dpc-5329	64	12	pathogen	pathogen	NOUN
dpc-5329	64	13	-	-	PUNCT
dpc-5329	64	14	associated	associate	VERB
dpc-5329	64	15	molecular	molecular	ADJ
dpc-5329	64	16	patterns	pattern	NOUN
dpc-5329	64	17	(	(	PUNCT
dpc-5329	64	18	pamps	pamp	NOUN
dpc-5329	64	19	)	)	PUNCT
dpc-5329	64	20	to	to	PART
dpc-5329	64	21	detect	detect	VERB
dpc-5329	64	22	harmful	harmful	ADJ
dpc-5329	64	23	microbes	microbe	NOUN
dpc-5329	64	24	,	,	PUNCT
dpc-5329	64	25	facilitating	facilitate	VERB
dpc-5329	64	26	immune	immune	ADJ
dpc-5329	64	27	surveillance	surveillance	NOUN
dpc-5329	64	28	and	and	CCONJ
dpc-5329	64	29	maintaining	maintain	VERB
dpc-5329	64	30	a	a	DET
dpc-5329	64	31	healthy	healthy	ADJ
dpc-5329	64	32	skin	skin	NOUN
dpc-5329	64	33	microbiome	microbiome	NOUN
dpc-5329	65	1	[	[	X
dpc-5329	65	2	10,11	10,11	NOUN
dpc-5329	65	3	]	]	PUNCT
dpc-5329	65	4	.	.	PUNCT
dpc-5329	66	1	other	other	ADJ
dpc-5329	66	2	cells	cell	NOUN
dpc-5329	66	3	,	,	PUNCT
dpc-5329	66	4	such	such	ADJ
dpc-5329	66	5	as	as	ADP
dpc-5329	66	6	langerhans	langerhans	PROPN
dpc-5329	66	7	cells	cell	NOUN
dpc-5329	66	8	and	and	CCONJ
dpc-5329	66	9	dendritic	dendritic	ADJ
dpc-5329	66	10	cells	cell	NOUN
dpc-5329	66	11	,	,	PUNCT
dpc-5329	66	12	recognize	recognize	VERB
dpc-5329	66	13	and	and	CCONJ
dpc-5329	66	14	present	present	ADJ
dpc-5329	66	15	antigens	antigen	NOUN
dpc-5329	66	16	to	to	ADP
dpc-5329	66	17	lymphocytes	lymphocyte	NOUN
dpc-5329	66	18	.	.	PUNCT
dpc-5329	67	1	t	t	PROPN
dpc-5329	67	2	and	and	CCONJ
dpc-5329	67	3	b	b	PROPN
dpc-5329	67	4	lymphocytes	lymphocyte	NOUN
dpc-5329	67	5	,	,	PUNCT
dpc-5329	67	6	macrophages	macrophage	NOUN
dpc-5329	67	7	,	,	PUNCT
dpc-5329	67	8	mast	mast	NOUN
dpc-5329	67	9	cells	cell	NOUN
dpc-5329	67	10	,	,	PUNCT
dpc-5329	67	11	and	and	CCONJ
dpc-5329	67	12	eosinophils	eosinophil	NOUN
dpc-5329	67	13	also	also	ADV
dpc-5329	67	14	function	function	VERB
dpc-5329	67	15	in	in	ADP
dpc-5329	67	16	the	the	DET
dpc-5329	67	17	skin	skin	NOUN
dpc-5329	67	18	to	to	PART
dpc-5329	67	19	amplify	amplify	VERB
dpc-5329	67	20	the	the	DET
dpc-5329	67	21	immune	immune	ADJ
dpc-5329	67	22	response	response	NOUN
dpc-5329	68	1	[	[	X
dpc-5329	68	2	11,12	11,12	NOUN
dpc-5329	68	3	]	]	PUNCT
dpc-5329	68	4	.	.	PUNCT
dpc-5329	69	1	collectively	collectively	ADV
dpc-5329	69	2	known	know	VERB
dpc-5329	69	3	as	as	ADP
dpc-5329	69	4	the	the	DET
dpc-5329	69	5	skin	skin	NOUN
dpc-5329	69	6	-	-	PUNCT
dpc-5329	69	7	associated	associate	VERB
dpc-5329	69	8	lymphoid	lymphoid	ADJ
dpc-5329	69	9	tissue	tissue	NOUN
dpc-5329	69	10	(	(	PUNCT
dpc-5329	69	11	salt	salt	NOUN
dpc-5329	69	12	)	)	PUNCT
dpc-5329	69	13	,	,	PUNCT
dpc-5329	69	14	this	this	DET
dpc-5329	69	15	network	network	NOUN
dpc-5329	69	16	of	of	ADP
dpc-5329	69	17	cells	cell	NOUN
dpc-5329	69	18	bridges	bridge	VERB
dpc-5329	69	19	the	the	DET
dpc-5329	69	20	innate	innate	ADJ
dpc-5329	69	21	and	and	CCONJ
dpc-5329	69	22	adaptive	adaptive	ADJ
dpc-5329	69	23	immune	immune	ADJ
dpc-5329	69	24	responses	response	NOUN
dpc-5329	69	25	[	[	X
dpc-5329	69	26	11	11	NUM
dpc-5329	69	27	]	]	PUNCT
dpc-5329	69	28	.	.	PUNCT
dpc-5329	70	1	in	in	ADP
dpc-5329	70	2	ad	ad	NOUN
dpc-5329	70	3	,	,	PUNCT
dpc-5329	70	4	skin	skin	NOUN
dpc-5329	70	5	barrier	barrier	NOUN
dpc-5329	70	6	dysfunction	dysfunction	NOUN
dpc-5329	70	7	lays	lay	VERB
dpc-5329	70	8	the	the	DET
dpc-5329	70	9	foundation	foundation	NOUN
dpc-5329	70	10	for	for	ADP
dpc-5329	70	11	disease	disease	NOUN
dpc-5329	70	12	progression	progression	NOUN
dpc-5329	70	13	.	.	PUNCT
dpc-5329	71	1	the	the	DET
dpc-5329	71	2	epithelial	epithelial	ADJ
dpc-5329	71	3	barrier	barrier	NOUN
dpc-5329	71	4	hypothesis	hypothesis	NOUN
dpc-5329	71	5	suggests	suggest	VERB
dpc-5329	71	6	that	that	SCONJ
dpc-5329	71	7	initial	initial	ADJ
dpc-5329	71	8	disturbances	disturbance	NOUN
dpc-5329	71	9	,	,	PUNCT
dpc-5329	71	10	whether	whether	SCONJ
dpc-5329	71	11	from	from	ADP
dpc-5329	71	12	flg	flg	PROPN
dpc-5329	71	13	dysfunction	dysfunction	NOUN
dpc-5329	71	14	or	or	CCONJ
dpc-5329	71	15	external	external	ADJ
dpc-5329	71	16	triggers	trigger	NOUN
dpc-5329	71	17	,	,	PUNCT
dpc-5329	71	18	allow	allow	VERB
dpc-5329	71	19	allergens	allergen	NOUN
dpc-5329	71	20	and	and	CCONJ
dpc-5329	71	21	pathogens	pathogen	NOUN
dpc-5329	71	22	to	to	PART
dpc-5329	71	23	penetrate	penetrate	VERB
dpc-5329	71	24	the	the	DET
dpc-5329	71	25	skin	skin	NOUN
dpc-5329	71	26	surface	surface	NOUN
dpc-5329	71	27	,	,	PUNCT
dpc-5329	71	28	leading	lead	VERB
dpc-5329	71	29	to	to	ADP
dpc-5329	71	30	chronic	chronic	ADJ
dpc-5329	71	31	inflammation	inflammation	NOUN
dpc-5329	71	32	due	due	ADP
dpc-5329	71	33	to	to	ADP
dpc-5329	71	34	an	an	DET
dpc-5329	71	35	overactive	overactive	ADJ
dpc-5329	71	36	th2	th2	PROPN
dpc-5329	71	37	pathway	pathway	NOUN
dpc-5329	71	38	seen	see	VERB
dpc-5329	71	39	in	in	ADP
dpc-5329	71	40	ad	ad	NOUN
dpc-5329	71	41	[	[	X
dpc-5329	71	42	13,14	13,14	NUM
dpc-5329	71	43	]	]	PUNCT
dpc-5329	71	44	.	.	PUNCT
dpc-5329	72	1	this	this	DET
dpc-5329	72	2	figure	figure	NOUN
dpc-5329	72	3	1	1	NUM
dpc-5329	72	4	.	.	PUNCT
dpc-5329	73	1	the	the	DET
dpc-5329	73	2	nice	nice	ADJ
dpc-5329	73	3	system	system	NOUN
dpc-5329	73	4	and	and	CCONJ
dpc-5329	73	5	gut	gut	NOUN
dpc-5329	73	6	-	-	PUNCT
dpc-5329	73	7	skin	skin	NOUN
dpc-5329	73	8	axis	axis	NOUN
dpc-5329	73	9	.	.	PUNCT
dpc-5329	74	1	the	the	DET
dpc-5329	74	2	nice	nice	ADJ
dpc-5329	74	3	system	system	NOUN
dpc-5329	74	4	(	(	PUNCT
dpc-5329	74	5	left	left	ADV
dpc-5329	74	6	)	)	PUNCT
dpc-5329	74	7	illustrates	illustrate	VERB
dpc-5329	74	8	the	the	DET
dpc-5329	74	9	multisystem	multisystem	NOUN
dpc-5329	74	10	crosstalk	crosstalk	VERB
dpc-5329	74	11	affecting	affect	VERB
dpc-5329	74	12	skin	skin	NOUN
dpc-5329	74	13	health	health	NOUN
dpc-5329	74	14	.	.	PUNCT
dpc-5329	75	1	the	the	DET
dpc-5329	75	2	gut	gut	NOUN
dpc-5329	75	3	-	-	PUNCT
dpc-5329	75	4	skin	skin	NOUN
dpc-5329	75	5	axis	axis	NOUN
dpc-5329	75	6	(	(	PUNCT
dpc-5329	75	7	right	right	ADJ
dpc-5329	75	8	)	)	PUNCT
dpc-5329	75	9	depicts	depict	VERB
dpc-5329	75	10	the	the	DET
dpc-5329	75	11	bidirectional	bidirectional	ADJ
dpc-5329	75	12	communication	communication	NOUN
dpc-5329	75	13	between	between	ADP
dpc-5329	75	14	the	the	DET
dpc-5329	75	15	two	two	NUM
dpc-5329	75	16	organs	organ	NOUN
dpc-5329	75	17	,	,	PUNCT
dpc-5329	75	18	suggesting	suggest	VERB
dpc-5329	75	19	that	that	SCONJ
dpc-5329	75	20	the	the	DET
dpc-5329	75	21	dysfunction	dysfunction	NOUN
dpc-5329	75	22	of	of	ADP
dpc-5329	75	23	one	one	NUM
dpc-5329	75	24	organ	organ	NOUN
dpc-5329	75	25	can	can	AUX
dpc-5329	75	26	influence	influence	VERB
dpc-5329	75	27	the	the	DET
dpc-5329	75	28	other	other	ADJ
dpc-5329	75	29	.	.	PUNCT
dpc-5329	76	1	expanding	expand	VERB
dpc-5329	76	2	on	on	ADP
dpc-5329	76	3	these	these	DET
dpc-5329	76	4	concepts	concept	NOUN
dpc-5329	76	5	,	,	PUNCT
dpc-5329	76	6	the	the	DET
dpc-5329	76	7	singe	singe	NOUN
dpc-5329	76	8	network	network	NOUN
dpc-5329	76	9	synthesizes	synthesize	VERB
dpc-5329	76	10	both	both	DET
dpc-5329	76	11	frameworks	framework	NOUN
dpc-5329	76	12	to	to	PART
dpc-5329	76	13	provide	provide	VERB
dpc-5329	76	14	a	a	DET
dpc-5329	76	15	more	more	ADV
dpc-5329	76	16	comprehensive	comprehensive	ADJ
dpc-5329	76	17	understanding	understanding	NOUN
dpc-5329	76	18	of	of	ADP
dpc-5329	76	19	ad	ad	NOUN
dpc-5329	76	20	pathogenesis	pathogenesis	NOUN
dpc-5329	76	21	.	.	PUNCT
dpc-5329	77	1	figure	figure	NOUN
dpc-5329	77	2	2	2	NUM
dpc-5329	77	3	.	.	PUNCT
dpc-5329	78	1	the	the	DET
dpc-5329	78	2	skin	skin	NOUN
dpc-5329	78	3	-	-	PUNCT
dpc-5329	78	4	immune	immune	NOUN
dpc-5329	78	5	-	-	PUNCT
dpc-5329	78	6	neuro	neuro	NOUN
dpc-5329	78	7	-	-	PUNCT
dpc-5329	78	8	gastro	gastro	NOUN
dpc-5329	78	9	-	-	PUNCT
dpc-5329	78	10	endocrine	endocrine	NOUN
dpc-5329	78	11	(	(	PUNCT
dpc-5329	78	12	singe	singe	NOUN
dpc-5329	78	13	)	)	PUNCT
dpc-5329	78	14	network	network	NOUN
dpc-5329	78	15	in	in	ADP
dpc-5329	78	16	atopic	atopic	NOUN
dpc-5329	78	17	dermatitis	dermatitis	NOUN
dpc-5329	78	18	(	(	PUNCT
dpc-5329	78	19	ad	ad	NOUN
dpc-5329	78	20	)	)	PUNCT
dpc-5329	78	21	.	.	PUNCT
dpc-5329	79	1	the	the	DET
dpc-5329	79	2	singe	singe	PROPN
dpc-5329	79	3	network	network	NOUN
dpc-5329	79	4	illustrates	illustrate	VERB
dpc-5329	79	5	the	the	DET
dpc-5329	79	6	multisystem	multisystem	NOUN
dpc-5329	79	7	interactions	interaction	NOUN
dpc-5329	79	8	involved	involve	VERB
dpc-5329	79	9	in	in	ADP
dpc-5329	79	10	ad	ad	NOUN
dpc-5329	79	11	.	.	PUNCT
dpc-5329	80	1	each	each	DET
dpc-5329	80	2	system	system	NOUN
dpc-5329	80	3	,	,	PUNCT
dpc-5329	80	4	interconnected	interconnect	VERB
dpc-5329	80	5	by	by	ADP
dpc-5329	80	6	bidirectional	bidirectional	ADJ
dpc-5329	80	7	communication	communication	NOUN
dpc-5329	80	8	,	,	PUNCT
dpc-5329	80	9	contributes	contribute	VERB
dpc-5329	80	10	to	to	ADP
dpc-5329	80	11	the	the	DET
dpc-5329	80	12	cycle	cycle	NOUN
dpc-5329	80	13	of	of	ADP
dpc-5329	80	14	disease	disease	NOUN
dpc-5329	80	15	progression	progression	NOUN
dpc-5329	80	16	in	in	ADP
dpc-5329	80	17	response	response	NOUN
dpc-5329	80	18	to	to	ADP
dpc-5329	80	19	internal	internal	ADJ
dpc-5329	80	20	and	and	CCONJ
dpc-5329	80	21	external	external	ADJ
dpc-5329	80	22	triggers	trigger	NOUN
dpc-5329	80	23	.	.	PUNCT
dpc-5329	81	1	4	4	NUM
dpc-5329	81	2	review	review	NOUN
dpc-5329	81	3	|	|	ADV
dpc-5329	81	4	dermatol	dermatol	ADJ
dpc-5329	81	5	pract	pract	NOUN
dpc-5329	81	6	concept	concept	NOUN
dpc-5329	81	7	.	.	PUNCT
dpc-5329	82	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	82	2	neuro	neuro	ADJ
dpc-5329	82	3	/	/	SYM
dpc-5329	82	4	nervous	nervous	ADJ
dpc-5329	82	5	involvement	involvement	NOUN
dpc-5329	82	6	in	in	ADP
dpc-5329	82	7	ad	ad	NOUN
dpc-5329	82	8	neuroinflammation	neuroinflammation	NOUN
dpc-5329	82	9	further	far	ADV
dpc-5329	82	10	facilitates	facilitate	VERB
dpc-5329	82	11	ad	ad	NOUN
dpc-5329	82	12	pathogenesis	pathogenesis	NOUN
dpc-5329	82	13	by	by	ADP
dpc-5329	82	14	exacerbating	exacerbate	VERB
dpc-5329	82	15	both	both	DET
dpc-5329	82	16	disease	disease	NOUN
dpc-5329	82	17	severity	severity	NOUN
dpc-5329	82	18	and	and	CCONJ
dpc-5329	82	19	symptom	symptom	NOUN
dpc-5329	82	20	progression	progression	NOUN
dpc-5329	82	21	.	.	PUNCT
dpc-5329	83	1	as	as	SCONJ
dpc-5329	83	2	previously	previously	ADV
dpc-5329	83	3	noted	note	VERB
dpc-5329	83	4	,	,	PUNCT
dpc-5329	83	5	immune	immune	ADJ
dpc-5329	83	6	mediators	mediator	NOUN
dpc-5329	83	7	stimulate	stimulate	VERB
dpc-5329	83	8	cutaneous	cutaneous	ADJ
dpc-5329	83	9	sensory	sensory	ADJ
dpc-5329	83	10	nerves	nerve	NOUN
dpc-5329	83	11	,	,	PUNCT
dpc-5329	83	12	intensifying	intensify	VERB
dpc-5329	83	13	the	the	DET
dpc-5329	83	14	itch	itch	NOUN
dpc-5329	83	15	-	-	PUNCT
dpc-5329	83	16	scratch	scratch	NOUN
dpc-5329	83	17	cycle	cycle	NOUN
dpc-5329	83	18	[	[	X
dpc-5329	83	19	8,22,23	8,22,23	NUM
dpc-5329	83	20	]	]	PUNCT
dpc-5329	83	21	.	.	PUNCT
dpc-5329	84	1	individuals	individual	NOUN
dpc-5329	84	2	with	with	ADP
dpc-5329	84	3	ad	ad	NOUN
dpc-5329	84	4	have	have	VERB
dpc-5329	84	5	alterations	alteration	NOUN
dpc-5329	84	6	of	of	ADP
dpc-5329	84	7	these	these	DET
dpc-5329	84	8	nerves	nerve	NOUN
dpc-5329	84	9	,	,	PUNCT
dpc-5329	84	10	including	include	VERB
dpc-5329	84	11	differences	difference	NOUN
dpc-5329	84	12	in	in	ADP
dpc-5329	84	13	density	density	NOUN
dpc-5329	84	14	,	,	PUNCT
dpc-5329	84	15	abnormal	abnormal	ADJ
dpc-5329	84	16	morphology	morphology	NOUN
dpc-5329	84	17	,	,	PUNCT
dpc-5329	84	18	and	and	CCONJ
dpc-5329	84	19	electrophysiologic	electrophysiologic	NOUN
dpc-5329	84	20	properties	property	NOUN
dpc-5329	84	21	,	,	PUNCT
dpc-5329	84	22	which	which	PRON
dpc-5329	84	23	may	may	AUX
dpc-5329	84	24	strengthen	strengthen	VERB
dpc-5329	84	25	signaling	signal	VERB
dpc-5329	84	26	to	to	ADP
dpc-5329	84	27	the	the	DET
dpc-5329	84	28	brain	brain	NOUN
dpc-5329	84	29	and	and	CCONJ
dpc-5329	84	30	prompt	prompt	VERB
dpc-5329	84	31	a	a	DET
dpc-5329	84	32	scratching	scratching	NOUN
dpc-5329	84	33	response	response	NOUN
dpc-5329	85	1	[	[	X
dpc-5329	85	2	8,24,25	8,24,25	NUM
dpc-5329	85	3	]	]	PUNCT
dpc-5329	85	4	.	.	PUNCT
dpc-5329	86	1	neuropeptides	neuropeptide	NOUN
dpc-5329	86	2	play	play	VERB
dpc-5329	86	3	a	a	DET
dpc-5329	86	4	crucial	crucial	ADJ
dpc-5329	86	5	role	role	NOUN
dpc-5329	86	6	in	in	ADP
dpc-5329	86	7	neurogenic	neurogenic	ADJ
dpc-5329	86	8	inflammation	inflammation	NOUN
dpc-5329	86	9	.	.	PUNCT
dpc-5329	87	1	in	in	ADP
dpc-5329	87	2	response	response	NOUN
dpc-5329	87	3	to	to	ADP
dpc-5329	87	4	a	a	DET
dpc-5329	87	5	trigger	trigger	NOUN
dpc-5329	87	6	,	,	PUNCT
dpc-5329	87	7	these	these	DET
dpc-5329	87	8	vasoactive	vasoactive	ADJ
dpc-5329	87	9	peptides	peptide	NOUN
dpc-5329	87	10	attract	attract	VERB
dpc-5329	87	11	inflammatory	inflammatory	ADJ
dpc-5329	87	12	mediators	mediator	NOUN
dpc-5329	87	13	like	like	ADP
dpc-5329	87	14	mast	mast	NOUN
dpc-5329	87	15	cells	cell	NOUN
dpc-5329	87	16	[	[	X
dpc-5329	87	17	26	26	NUM
dpc-5329	87	18	]	]	PUNCT
dpc-5329	87	19	.	.	PUNCT
dpc-5329	88	1	neuropeptides	neuropeptide	NOUN
dpc-5329	88	2	also	also	ADV
dpc-5329	88	3	stimulate	stimulate	VERB
dpc-5329	88	4	keratinocyte	keratinocyte	NOUN
dpc-5329	88	5	proliferation	proliferation	NOUN
dpc-5329	88	6	,	,	PUNCT
dpc-5329	88	7	leading	lead	VERB
dpc-5329	88	8	to	to	ADP
dpc-5329	88	9	and	and	CCONJ
dpc-5329	88	10	epidermal	epidermal	ADJ
dpc-5329	88	11	thickening	thickening	NOUN
dpc-5329	88	12	,	,	PUNCT
dpc-5329	88	13	which	which	PRON
dpc-5329	88	14	are	be	AUX
dpc-5329	88	15	key	key	ADJ
dpc-5329	88	16	aspects	aspect	NOUN
dpc-5329	88	17	of	of	ADP
dpc-5329	88	18	eczematous	eczematous	ADJ
dpc-5329	88	19	lesions	lesion	NOUN
dpc-5329	88	20	[	[	X
dpc-5329	88	21	23	23	NUM
dpc-5329	88	22	]	]	PUNCT
dpc-5329	88	23	.	.	PUNCT
dpc-5329	89	1	substance	substance	NOUN
dpc-5329	89	2	p	p	NOUN
dpc-5329	89	3	(	(	PUNCT
dpc-5329	89	4	sp	sp	NOUN
dpc-5329	89	5	)	)	PUNCT
dpc-5329	89	6	,	,	PUNCT
dpc-5329	89	7	markedly	markedly	ADV
dpc-5329	89	8	overexpressed	overexpresse	VERB
dpc-5329	89	9	in	in	ADP
dpc-5329	89	10	those	those	PRON
dpc-5329	89	11	with	with	ADP
dpc-5329	89	12	ad	ad	NOUN
dpc-5329	89	13	,	,	PUNCT
dpc-5329	89	14	drives	drive	VERB
dpc-5329	89	15	itch	itch	NOUN
dpc-5329	89	16	perception	perception	NOUN
dpc-5329	89	17	by	by	ADP
dpc-5329	89	18	provoking	provoke	VERB
dpc-5329	89	19	mast	mast	NOUN
dpc-5329	89	20	cell	cell	NOUN
dpc-5329	89	21	degranulation	degranulation	NOUN
dpc-5329	90	1	[	[	X
dpc-5329	90	2	23,26	23,26	X
dpc-5329	90	3	]	]	X
dpc-5329	90	4	.	.	PUNCT
dpc-5329	91	1	interestingly	interestingly	ADV
dpc-5329	91	2	,	,	PUNCT
dpc-5329	91	3	sp	sp	NOUN
dpc-5329	91	4	is	be	AUX
dpc-5329	91	5	also	also	ADV
dpc-5329	91	6	produced	produce	VERB
dpc-5329	91	7	by	by	ADP
dpc-5329	91	8	keratinocytes	keratinocyte	NOUN
dpc-5329	91	9	,	,	PUNCT
dpc-5329	91	10	suggesting	suggest	VERB
dpc-5329	91	11	its	its	PRON
dpc-5329	91	12	utility	utility	NOUN
dpc-5329	91	13	as	as	ADP
dpc-5329	91	14	a	a	DET
dpc-5329	91	15	potential	potential	ADJ
dpc-5329	91	16	target	target	NOUN
dpc-5329	91	17	for	for	ADP
dpc-5329	91	18	future	future	ADJ
dpc-5329	91	19	therapies	therapy	NOUN
dpc-5329	91	20	[	[	X
dpc-5329	91	21	23	23	NUM
dpc-5329	91	22	]	]	PUNCT
dpc-5329	91	23	.	.	PUNCT
dpc-5329	92	1	by	by	ADP
dpc-5329	92	2	activating	activate	VERB
dpc-5329	92	3	immune	immune	ADJ
dpc-5329	92	4	responses	response	NOUN
dpc-5329	92	5	and	and	CCONJ
dpc-5329	92	6	maintaining	maintain	VERB
dpc-5329	92	7	bidirectional	bidirectional	ADJ
dpc-5329	92	8	interactions	interaction	NOUN
dpc-5329	92	9	with	with	ADP
dpc-5329	92	10	the	the	DET
dpc-5329	92	11	skin	skin	NOUN
dpc-5329	92	12	,	,	PUNCT
dpc-5329	92	13	sp	sp	ADP
dpc-5329	92	14	serves	serve	NOUN
dpc-5329	92	15	as	as	ADP
dpc-5329	92	16	a	a	DET
dpc-5329	92	17	critical	critical	ADJ
dpc-5329	92	18	connector	connector	NOUN
dpc-5329	92	19	between	between	ADP
dpc-5329	92	20	various	various	ADJ
dpc-5329	92	21	systems	system	NOUN
dpc-5329	92	22	.	.	PUNCT
dpc-5329	93	1	another	another	DET
dpc-5329	93	2	significant	significant	ADJ
dpc-5329	93	3	pro	pro	ADJ
dpc-5329	93	4	-	-	ADJ
dpc-5329	93	5	inflammatory	inflammatory	ADJ
dpc-5329	93	6	neuropeptide	neuropeptide	NOUN
dpc-5329	93	7	involved	involve	VERB
dpc-5329	93	8	in	in	ADP
dpc-5329	93	9	ad	ad	NOUN
dpc-5329	93	10	pathogenesis	pathogenesis	NOUN
dpc-5329	93	11	is	be	AUX
dpc-5329	93	12	calcitonin	calcitonin	ADJ
dpc-5329	93	13	gene	gene	NOUN
dpc-5329	93	14	-	-	PUNCT
dpc-5329	93	15	related	relate	VERB
dpc-5329	93	16	peptide	peptide	NOUN
dpc-5329	93	17	(	(	PUNCT
dpc-5329	93	18	cgrp	cgrp	PROPN
dpc-5329	93	19	)	)	PUNCT
dpc-5329	93	20	.	.	PUNCT
dpc-5329	94	1	elevated	elevate	VERB
dpc-5329	94	2	in	in	ADP
dpc-5329	94	3	response	response	NOUN
dpc-5329	94	4	to	to	ADP
dpc-5329	94	5	ad	ad	NOUN
dpc-5329	94	6	exacerbations	exacerbation	NOUN
dpc-5329	94	7	,	,	PUNCT
dpc-5329	94	8	cgrp	cgrp	PROPN
dpc-5329	94	9	affects	affect	VERB
dpc-5329	94	10	both	both	DET
dpc-5329	94	11	central	central	ADJ
dpc-5329	94	12	pruritus	pruritus	NOUN
dpc-5329	94	13	and	and	CCONJ
dpc-5329	94	14	peripheral	peripheral	ADJ
dpc-5329	94	15	neuroinflammation	neuroinflammation	NOUN
dpc-5329	94	16	[	[	X
dpc-5329	94	17	8	8	NUM
dpc-5329	94	18	]	]	PUNCT
dpc-5329	94	19	.	.	PUNCT
dpc-5329	95	1	it	it	PRON
dpc-5329	95	2	activates	activate	VERB
dpc-5329	95	3	immune	immune	ADJ
dpc-5329	95	4	responses	response	NOUN
dpc-5329	95	5	by	by	ADP
dpc-5329	95	6	activating	activate	VERB
dpc-5329	95	7	dendritic	dendritic	ADJ
dpc-5329	95	8	cells	cell	NOUN
dpc-5329	95	9	and	and	CCONJ
dpc-5329	95	10	th2	th2	PROPN
dpc-5329	95	11	cells	cell	NOUN
dpc-5329	95	12	as	as	ADV
dpc-5329	95	13	well	well	ADV
dpc-5329	95	14	as	as	ADP
dpc-5329	95	15	inducing	induce	VERB
dpc-5329	95	16	epidermal	epidermal	ADJ
dpc-5329	95	17	changes	change	NOUN
dpc-5329	95	18	through	through	ADP
dpc-5329	95	19	keratinocyte	keratinocyte	NOUN
dpc-5329	95	20	proliferation	proliferation	NOUN
dpc-5329	95	21	[	[	X
dpc-5329	95	22	8,17	8,17	NUM
dpc-5329	95	23	]	]	PUNCT
dpc-5329	95	24	.	.	PUNCT
dpc-5329	96	1	further	far	ADV
dpc-5329	96	2	,	,	PUNCT
dpc-5329	96	3	pathogens	pathogen	NOUN
dpc-5329	96	4	like	like	ADP
dpc-5329	96	5	s.	s.	PROPN
dpc-5329	96	6	aureus	aureus	PROPN
dpc-5329	96	7	directly	directly	ADV
dpc-5329	96	8	stimulate	stimulate	VERB
dpc-5329	96	9	local	local	ADJ
dpc-5329	96	10	cgrp	cgrp	NOUN
dpc-5329	96	11	release	release	NOUN
dpc-5329	96	12	,	,	PUNCT
dpc-5329	96	13	thus	thus	ADV
dpc-5329	96	14	impairing	impair	VERB
dpc-5329	96	15	bacterial	bacterial	ADJ
dpc-5329	96	16	clearance	clearance	NOUN
dpc-5329	96	17	by	by	ADP
dpc-5329	96	18	modulating	modulate	VERB
dpc-5329	96	19	the	the	DET
dpc-5329	96	20	immune	immune	ADJ
dpc-5329	96	21	response	response	NOUN
dpc-5329	96	22	[	[	X
dpc-5329	96	23	17	17	NUM
dpc-5329	96	24	]	]	PUNCT
dpc-5329	96	25	.	.	PUNCT
dpc-5329	97	1	inflammatory	inflammatory	ADJ
dpc-5329	97	2	response	response	NOUN
dpc-5329	97	3	results	result	NOUN
dpc-5329	97	4	in	in	ADP
dpc-5329	97	5	increased	increase	VERB
dpc-5329	97	6	activity	activity	NOUN
dpc-5329	97	7	of	of	ADP
dpc-5329	97	8	cytokines	cytokine	NOUN
dpc-5329	97	9	like	like	ADP
dpc-5329	97	10	il-4	il-4	NOUN
dpc-5329	97	11	,	,	PUNCT
dpc-5329	97	12	il-5	il-5	PROPN
dpc-5329	97	13	,	,	PUNCT
dpc-5329	97	14	and	and	CCONJ
dpc-5329	97	15	il-13	il-13	PRON
dpc-5329	97	16	,	,	PUNCT
dpc-5329	97	17	which	which	PRON
dpc-5329	97	18	further	far	ADV
dpc-5329	97	19	impair	impair	VERB
dpc-5329	97	20	the	the	DET
dpc-5329	97	21	skin	skin	NOUN
dpc-5329	97	22	barrier	barrier	NOUN
dpc-5329	97	23	by	by	ADP
dpc-5329	97	24	inducing	induce	VERB
dpc-5329	97	25	keratinocyte	keratinocyte	NOUN
dpc-5329	97	26	apoptosis	apoptosis	NOUN
dpc-5329	97	27	and	and	CCONJ
dpc-5329	97	28	disrupting	disrupt	VERB
dpc-5329	97	29	essential	essential	ADJ
dpc-5329	97	30	barrier	barrier	NOUN
dpc-5329	97	31	proteins	protein	NOUN
dpc-5329	97	32	[	[	X
dpc-5329	97	33	1,12,14	1,12,14	NUM
dpc-5329	97	34	]	]	PUNCT
dpc-5329	97	35	.	.	PUNCT
dpc-5329	98	1	the	the	DET
dpc-5329	98	2	resulting	result	VERB
dpc-5329	98	3	transepidermal	transepidermal	ADJ
dpc-5329	98	4	water	water	NOUN
dpc-5329	98	5	loss	loss	NOUN
dpc-5329	98	6	and	and	CCONJ
dpc-5329	98	7	susceptibility	susceptibility	NOUN
dpc-5329	98	8	to	to	PART
dpc-5329	98	9	pathogen	pathogen	VERB
dpc-5329	98	10	infiltration	infiltration	NOUN
dpc-5329	98	11	exacerbates	exacerbate	VERB
dpc-5329	98	12	ad	ad	NOUN
dpc-5329	98	13	symptoms	symptom	NOUN
dpc-5329	98	14	like	like	ADP
dpc-5329	98	15	dry	dry	ADJ
dpc-5329	98	16	skin	skin	NOUN
dpc-5329	98	17	and	and	CCONJ
dpc-5329	98	18	pruritus	pruritus	NOUN
dpc-5329	99	1	[	[	X
dpc-5329	99	2	14,15	14,15	NUM
dpc-5329	99	3	]	]	X
dpc-5329	99	4	(	(	PUNCT
dpc-5329	99	5	figure	figure	NOUN
dpc-5329	99	6	3	3	NUM
dpc-5329	99	7	)	)	PUNCT
dpc-5329	99	8	.	.	PUNCT
dpc-5329	100	1	while	while	SCONJ
dpc-5329	100	2	the	the	DET
dpc-5329	100	3	acute	acute	ADJ
dpc-5329	100	4	phase	phase	NOUN
dpc-5329	100	5	of	of	ADP
dpc-5329	100	6	ad	ad	NOUN
dpc-5329	100	7	is	be	AUX
dpc-5329	100	8	mediated	mediate	VERB
dpc-5329	100	9	by	by	ADP
dpc-5329	100	10	th2	th2	PROPN
dpc-5329	100	11	overactivity	overactivity	NOUN
dpc-5329	100	12	,	,	PUNCT
dpc-5329	100	13	the	the	DET
dpc-5329	100	14	chronic	chronic	ADJ
dpc-5329	100	15	state	state	NOUN
dpc-5329	100	16	of	of	ADP
dpc-5329	100	17	this	this	DET
dpc-5329	100	18	disease	disease	NOUN
dpc-5329	100	19	demonstrates	demonstrate	VERB
dpc-5329	100	20	a	a	DET
dpc-5329	100	21	shift	shift	NOUN
dpc-5329	100	22	to	to	ADP
dpc-5329	100	23	more	more	ADJ
dpc-5329	100	24	th1	th1	NOUN
dpc-5329	100	25	/	/	SYM
dpc-5329	100	26	th22	th22	PROPN
dpc-5329	100	27	signaling	signal	VERB
dpc-5329	100	28	[	[	X
dpc-5329	100	29	1,15	1,15	NUM
dpc-5329	100	30	]	]	PUNCT
dpc-5329	100	31	.	.	PUNCT
dpc-5329	101	1	th1	th1	PROPN
dpc-5329	101	2	engagement	engagement	NOUN
dpc-5329	101	3	leads	lead	VERB
dpc-5329	101	4	to	to	ADP
dpc-5329	101	5	increased	increase	VERB
dpc-5329	101	6	circulating	circulate	VERB
dpc-5329	101	7	proinflammatory	proinflammatory	ADJ
dpc-5329	101	8	cytokines	cytokine	NOUN
dpc-5329	101	9	like	like	ADP
dpc-5329	101	10	il1	il1	PROPN
dpc-5329	101	11	,	,	PUNCT
dpc-5329	101	12	while	while	SCONJ
dpc-5329	101	13	th22	th22	PROPN
dpc-5329	101	14	excitement	excitement	NOUN
dpc-5329	101	15	stimulates	stimulate	VERB
dpc-5329	101	16	skin	skin	NOUN
dpc-5329	101	17	remodeling	remodeling	NOUN
dpc-5329	101	18	and	and	CCONJ
dpc-5329	101	19	thickening	thickening	NOUN
dpc-5329	101	20	.	.	PUNCT
dpc-5329	102	1	together	together	ADV
dpc-5329	102	2	,	,	PUNCT
dpc-5329	102	3	this	this	DET
dpc-5329	102	4	chronic	chronic	ADJ
dpc-5329	102	5	immune	immune	ADJ
dpc-5329	102	6	activation	activation	NOUN
dpc-5329	102	7	causes	cause	VERB
dpc-5329	102	8	epidermal	epidermal	ADJ
dpc-5329	102	9	thickening	thickening	NOUN
dpc-5329	102	10	and	and	CCONJ
dpc-5329	102	11	hyperplasia	hyperplasia	NOUN
dpc-5329	103	1	[	[	X
dpc-5329	103	2	1,16	1,16	NOUN
dpc-5329	103	3	]	]	X
dpc-5329	103	4	.	.	PUNCT
dpc-5329	104	1	central	central	ADJ
dpc-5329	104	2	to	to	ADP
dpc-5329	104	3	the	the	DET
dpc-5329	104	4	manifestations	manifestation	NOUN
dpc-5329	104	5	of	of	ADP
dpc-5329	104	6	chronic	chronic	ADJ
dpc-5329	104	7	ad	ad	NOUN
dpc-5329	104	8	is	be	AUX
dpc-5329	104	9	the	the	DET
dpc-5329	104	10	itch	itch	NOUN
dpc-5329	104	11	-	-	PUNCT
dpc-5329	104	12	scratch	scratch	NOUN
dpc-5329	104	13	cycle	cycle	NOUN
dpc-5329	104	14	,	,	PUNCT
dpc-5329	104	15	where	where	SCONJ
dpc-5329	104	16	immune	immune	NOUN
dpc-5329	104	17	-	-	PUNCT
dpc-5329	104	18	mediated	mediate	VERB
dpc-5329	104	19	inflammation	inflammation	NOUN
dpc-5329	104	20	induces	induce	VERB
dpc-5329	104	21	pruritus	pruritus	PROPN
dpc-5329	104	22	,	,	PUNCT
dpc-5329	104	23	leading	lead	VERB
dpc-5329	104	24	to	to	ADP
dpc-5329	104	25	scratching	scratching	NOUN
dpc-5329	104	26	that	that	PRON
dpc-5329	104	27	worsens	worsen	VERB
dpc-5329	104	28	skin	skin	NOUN
dpc-5329	104	29	barrier	barrier	NOUN
dpc-5329	104	30	integrity	integrity	NOUN
dpc-5329	104	31	and	and	CCONJ
dpc-5329	104	32	exacerbates	exacerbate	VERB
dpc-5329	104	33	ad	ad	NOUN
dpc-5329	104	34	symptoms	symptom	NOUN
dpc-5329	104	35	[	[	X
dpc-5329	104	36	17	17	NUM
dpc-5329	104	37	]	]	PUNCT
dpc-5329	104	38	.	.	PUNCT
dpc-5329	105	1	the	the	DET
dpc-5329	105	2	immune	immune	ADJ
dpc-5329	105	3	response	response	NOUN
dpc-5329	105	4	communicates	communicate	VERB
dpc-5329	105	5	with	with	ADP
dpc-5329	105	6	cutaneous	cutaneous	ADJ
dpc-5329	105	7	nerves	nerve	NOUN
dpc-5329	105	8	through	through	ADP
dpc-5329	105	9	cytokines	cytokine	NOUN
dpc-5329	105	10	like	like	ADP
dpc-5329	105	11	il-4	il-4	NOUN
dpc-5329	105	12	,	,	PUNCT
dpc-5329	105	13	il-13	il-13	ADV
dpc-5329	105	14	,	,	PUNCT
dpc-5329	105	15	and	and	CCONJ
dpc-5329	105	16	il-31	il-31	PUNCT
dpc-5329	105	17	[	[	X
dpc-5329	105	18	18,19	18,19	NUM
dpc-5329	105	19	]	]	PUNCT
dpc-5329	105	20	.	.	PUNCT
dpc-5329	106	1	il31	il31	PROPN
dpc-5329	106	2	,	,	PUNCT
dpc-5329	106	3	in	in	ADP
dpc-5329	106	4	particular	particular	ADJ
dpc-5329	106	5	,	,	PUNCT
dpc-5329	106	6	is	be	AUX
dpc-5329	106	7	known	know	VERB
dpc-5329	106	8	as	as	ADP
dpc-5329	106	9	the	the	DET
dpc-5329	106	10	“	"	PUNCT
dpc-5329	106	11	itch	itch	NOUN
dpc-5329	106	12	cytokine	cytokine	NOUN
dpc-5329	106	13	”	"	PUNCT
dpc-5329	106	14	for	for	ADP
dpc-5329	106	15	its	its	PRON
dpc-5329	106	16	pivotal	pivotal	ADJ
dpc-5329	106	17	role	role	NOUN
dpc-5329	106	18	in	in	ADP
dpc-5329	106	19	enhancing	enhance	VERB
dpc-5329	106	20	the	the	DET
dpc-5329	106	21	sensitivity	sensitivity	NOUN
dpc-5329	106	22	of	of	ADP
dpc-5329	106	23	these	these	DET
dpc-5329	106	24	nerves	nerve	NOUN
dpc-5329	106	25	,	,	PUNCT
dpc-5329	106	26	intensifying	intensify	VERB
dpc-5329	106	27	chronic	chronic	ADJ
dpc-5329	106	28	itch	itch	NOUN
dpc-5329	106	29	sensation	sensation	NOUN
dpc-5329	106	30	through	through	ADP
dpc-5329	106	31	neuroimmune	neuroimmune	NOUN
dpc-5329	106	32	pathways	pathway	NOUN
dpc-5329	107	1	[	[	X
dpc-5329	107	2	8,19	8,19	NUM
dpc-5329	107	3	]	]	PUNCT
dpc-5329	107	4	(	(	PUNCT
dpc-5329	107	5	figure	figure	NOUN
dpc-5329	107	6	4	4	NUM
dpc-5329	107	7	)	)	PUNCT
dpc-5329	107	8	.	.	PUNCT
dpc-5329	108	1	the	the	DET
dpc-5329	108	2	disrupted	disrupt	VERB
dpc-5329	108	3	skin	skin	NOUN
dpc-5329	108	4	barrier	barrier	NOUN
dpc-5329	108	5	in	in	ADP
dpc-5329	108	6	ad	ad	NOUN
dpc-5329	108	7	also	also	ADV
dpc-5329	108	8	predisposes	predispose	VERB
dpc-5329	108	9	to	to	ADP
dpc-5329	108	10	microbial	microbial	ADJ
dpc-5329	108	11	colonization	colonization	NOUN
dpc-5329	108	12	,	,	PUNCT
dpc-5329	108	13	notably	notably	ADV
dpc-5329	108	14	staphylococcus	staphylococcus	NOUN
dpc-5329	108	15	aureus	aureus	NOUN
dpc-5329	108	16	,	,	PUNCT
dpc-5329	108	17	which	which	PRON
dpc-5329	108	18	worsens	worsen	VERB
dpc-5329	108	19	the	the	DET
dpc-5329	108	20	disease	disease	NOUN
dpc-5329	108	21	severity	severity	NOUN
dpc-5329	108	22	and	and	CCONJ
dpc-5329	108	23	leads	lead	VERB
dpc-5329	108	24	to	to	ADP
dpc-5329	108	25	a	a	DET
dpc-5329	108	26	microbial	microbial	ADJ
dpc-5329	108	27	dysbiosis	dysbiosis	NOUN
dpc-5329	108	28	.	.	PUNCT
dpc-5329	109	1	this	this	DET
dpc-5329	109	2	imbalance	imbalance	NOUN
dpc-5329	109	3	heightens	heighten	VERB
dpc-5329	109	4	the	the	DET
dpc-5329	109	5	th2	th2	PROPN
dpc-5329	109	6	immune	immune	ADJ
dpc-5329	109	7	response	response	NOUN
dpc-5329	109	8	and	and	CCONJ
dpc-5329	109	9	increases	increase	VERB
dpc-5329	109	10	the	the	DET
dpc-5329	109	11	risk	risk	NOUN
dpc-5329	109	12	of	of	ADP
dpc-5329	109	13	infection	infection	NOUN
dpc-5329	109	14	,	,	PUNCT
dpc-5329	109	15	underscoring	underscore	VERB
dpc-5329	109	16	the	the	DET
dpc-5329	109	17	intricate	intricate	ADJ
dpc-5329	109	18	relationship	relationship	NOUN
dpc-5329	109	19	between	between	ADP
dpc-5329	109	20	microbial	microbial	ADJ
dpc-5329	109	21	colonization	colonization	NOUN
dpc-5329	109	22	and	and	CCONJ
dpc-5329	109	23	immune	immune	ADJ
dpc-5329	109	24	dysregulation	dysregulation	NOUN
dpc-5329	109	25	in	in	ADP
dpc-5329	109	26	ad	ad	NOUN
dpc-5329	109	27	[	[	X
dpc-5329	109	28	20,21	20,21	NUM
dpc-5329	109	29	]	]	PUNCT
dpc-5329	109	30	.	.	PUNCT
dpc-5329	110	1	figure	figure	NOUN
dpc-5329	110	2	3	3	NUM
dpc-5329	110	3	.	.	PUNCT
dpc-5329	110	4	pathophysiology	pathophysiology	NOUN
dpc-5329	110	5	of	of	ADP
dpc-5329	110	6	atopic	atopic	NOUN
dpc-5329	110	7	dermatitis	dermatitis	NOUN
dpc-5329	110	8	(	(	PUNCT
dpc-5329	110	9	ad	ad	NOUN
dpc-5329	110	10	)	)	PUNCT
dpc-5329	110	11	.	.	PUNCT
dpc-5329	111	1	in	in	ADP
dpc-5329	111	2	ad	ad	NOUN
dpc-5329	111	3	,	,	PUNCT
dpc-5329	111	4	the	the	DET
dpc-5329	111	5	skin	skin	NOUN
dpc-5329	111	6	barrier	barrier	NOUN
dpc-5329	111	7	dysfunction	dysfunction	NOUN
dpc-5329	111	8	(	(	PUNCT
dpc-5329	111	9	1	1	X
dpc-5329	111	10	)	)	PUNCT
dpc-5329	111	11	allows	allow	VERB
dpc-5329	111	12	allergens	allergen	NOUN
dpc-5329	111	13	,	,	PUNCT
dpc-5329	111	14	irritants	irritant	NOUN
dpc-5329	111	15	,	,	PUNCT
dpc-5329	111	16	and	and	CCONJ
dpc-5329	111	17	pathogens	pathogen	NOUN
dpc-5329	111	18	(	(	PUNCT
dpc-5329	111	19	2	2	NUM
dpc-5329	111	20	)	)	PUNCT
dpc-5329	111	21	to	to	PART
dpc-5329	111	22	penetrate	penetrate	VERB
dpc-5329	111	23	into	into	ADP
dpc-5329	111	24	the	the	DET
dpc-5329	111	25	skin	skin	NOUN
dpc-5329	111	26	(	(	PUNCT
dpc-5329	111	27	3	3	NUM
dpc-5329	111	28	)	)	PUNCT
dpc-5329	111	29	,	,	PUNCT
dpc-5329	111	30	activating	activate	VERB
dpc-5329	111	31	an	an	DET
dpc-5329	111	32	exaggerated	exaggerated	ADJ
dpc-5329	111	33	th2	th2	PROPN
dpc-5329	111	34	immune	immune	ADJ
dpc-5329	111	35	response	response	NOUN
dpc-5329	111	36	(	(	PUNCT
dpc-5329	111	37	4	4	NUM
dpc-5329	111	38	)	)	PUNCT
dpc-5329	111	39	.	.	PUNCT
dpc-5329	112	1	the	the	DET
dpc-5329	112	2	subsequent	subsequent	ADJ
dpc-5329	112	3	cytokine	cytokine	NOUN
dpc-5329	112	4	release	release	NOUN
dpc-5329	112	5	,	,	PUNCT
dpc-5329	112	6	including	include	VERB
dpc-5329	112	7	il-4	il-4	NOUN
dpc-5329	112	8	,	,	PUNCT
dpc-5329	112	9	il-5	il-5	PROPN
dpc-5329	112	10	,	,	PUNCT
dpc-5329	112	11	il-13	il-13	ADV
dpc-5329	112	12	,	,	PUNCT
dpc-5329	112	13	and	and	CCONJ
dpc-5329	112	14	il-31	il-31	PUNCT
dpc-5329	112	15	(	(	PUNCT
dpc-5329	112	16	5	5	NUM
dpc-5329	112	17	)	)	PUNCT
dpc-5329	112	18	,	,	PUNCT
dpc-5329	112	19	further	far	ADV
dpc-5329	112	20	weakens	weaken	VERB
dpc-5329	112	21	the	the	DET
dpc-5329	112	22	skin	skin	NOUN
dpc-5329	112	23	barrier	barrier	NOUN
dpc-5329	112	24	integrity	integrity	NOUN
dpc-5329	112	25	,	,	PUNCT
dpc-5329	112	26	leading	lead	VERB
dpc-5329	112	27	to	to	ADP
dpc-5329	112	28	water	water	NOUN
dpc-5329	112	29	loss	loss	NOUN
dpc-5329	112	30	and	and	CCONJ
dpc-5329	112	31	worsening	worsen	VERB
dpc-5329	112	32	symptoms	symptom	NOUN
dpc-5329	112	33	(	(	PUNCT
dpc-5329	112	34	6	6	NUM
dpc-5329	112	35	)	)	PUNCT
dpc-5329	112	36	.	.	PUNCT
dpc-5329	113	1	review	review	VERB
dpc-5329	113	2	|	|	ADV
dpc-5329	113	3	dermatol	dermatol	ADJ
dpc-5329	113	4	pract	pract	NOUN
dpc-5329	113	5	concept	concept	NOUN
dpc-5329	113	6	.	.	PUNCT
dpc-5329	114	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	114	2	5	5	NUM
dpc-5329	114	3	[	[	SYM
dpc-5329	114	4	30	30	NUM
dpc-5329	114	5	]	]	PUNCT
dpc-5329	114	6	.	.	PUNCT
dpc-5329	115	1	gut	gut	NOUN
dpc-5329	115	2	dysbiosis	dysbiosis	NOUN
dpc-5329	115	3	is	be	AUX
dpc-5329	115	4	also	also	ADV
dpc-5329	115	5	linked	link	VERB
dpc-5329	115	6	to	to	PART
dpc-5329	115	7	altered	alter	VERB
dpc-5329	115	8	neuroendocrine	neuroendocrine	NOUN
dpc-5329	115	9	signaling	signal	VERB
dpc-5329	115	10	by	by	ADP
dpc-5329	115	11	modulating	modulate	VERB
dpc-5329	115	12	serotonin	serotonin	NOUN
dpc-5329	115	13	and	and	CCONJ
dpc-5329	115	14	gaba	gaba	NOUN
dpc-5329	115	15	levels	level	NOUN
dpc-5329	115	16	,	,	PUNCT
dpc-5329	115	17	which	which	PRON
dpc-5329	115	18	both	both	CCONJ
dpc-5329	115	19	further	far	ADV
dpc-5329	115	20	regulate	regulate	VERB
dpc-5329	115	21	ad	ad	NOUN
dpc-5329	115	22	symptoms	symptom	NOUN
dpc-5329	115	23	.	.	PUNCT
dpc-5329	116	1	the	the	DET
dpc-5329	116	2	gut	gut	NOUN
dpc-5329	116	3	-	-	PUNCT
dpc-5329	116	4	skin	skin	NOUN
dpc-5329	116	5	connection	connection	NOUN
dpc-5329	116	6	offers	offer	VERB
dpc-5329	116	7	potential	potential	ADJ
dpc-5329	116	8	as	as	ADP
dpc-5329	116	9	a	a	DET
dpc-5329	116	10	therapeutic	therapeutic	ADJ
dpc-5329	116	11	target	target	NOUN
dpc-5329	116	12	by	by	ADP
dpc-5329	116	13	leveraging	leverage	VERB
dpc-5329	116	14	the	the	DET
dpc-5329	116	15	microbiotic	microbiotic	ADJ
dpc-5329	116	16	and	and	CCONJ
dpc-5329	116	17	metabolic	metabolic	NOUN
dpc-5329	116	18	contributions	contribution	NOUN
dpc-5329	116	19	.	.	PUNCT
dpc-5329	117	1	diet	diet	NOUN
dpc-5329	117	2	modifications	modification	NOUN
dpc-5329	117	3	,	,	PUNCT
dpc-5329	117	4	probiotics	probiotic	NOUN
dpc-5329	117	5	,	,	PUNCT
dpc-5329	117	6	and	and	CCONJ
dpc-5329	117	7	postbiotics	postbiotic	NOUN
dpc-5329	117	8	are	be	AUX
dpc-5329	117	9	being	be	AUX
dpc-5329	117	10	explored	explore	VERB
dpc-5329	117	11	for	for	ADP
dpc-5329	117	12	their	their	PRON
dpc-5329	117	13	ability	ability	NOUN
dpc-5329	117	14	to	to	PART
dpc-5329	117	15	reduce	reduce	VERB
dpc-5329	117	16	ad	ad	NOUN
dpc-5329	117	17	burden	burden	NOUN
dpc-5329	117	18	on	on	ADP
dpc-5329	117	19	affected	affect	VERB
dpc-5329	117	20	individuals	individual	NOUN
dpc-5329	117	21	[	[	X
dpc-5329	117	22	28	28	NUM
dpc-5329	117	23	]	]	PUNCT
dpc-5329	117	24	.	.	PUNCT
dpc-5329	118	1	given	give	VERB
dpc-5329	118	2	the	the	DET
dpc-5329	118	3	extensive	extensive	ADJ
dpc-5329	118	4	contributions	contribution	NOUN
dpc-5329	118	5	by	by	ADP
dpc-5329	118	6	the	the	DET
dpc-5329	118	7	gut	gut	NOUN
dpc-5329	118	8	-	-	PUNCT
dpc-5329	118	9	skin	skin	NOUN
dpc-5329	118	10	axis	axis	NOUN
dpc-5329	118	11	,	,	PUNCT
dpc-5329	118	12	it	it	PRON
dpc-5329	118	13	is	be	AUX
dpc-5329	118	14	imperative	imperative	ADJ
dpc-5329	118	15	to	to	PART
dpc-5329	118	16	incorporate	incorporate	VERB
dpc-5329	118	17	the	the	DET
dpc-5329	118	18	gi	gi	NOUN
dpc-5329	118	19	system	system	NOUN
dpc-5329	118	20	into	into	ADP
dpc-5329	118	21	understanding	understand	VERB
dpc-5329	118	22	dermatological	dermatological	ADJ
dpc-5329	118	23	diseases	disease	NOUN
dpc-5329	118	24	,	,	PUNCT
dpc-5329	118	25	especially	especially	ADV
dpc-5329	118	26	systemic	systemic	ADJ
dpc-5329	118	27	conditions	condition	NOUN
dpc-5329	118	28	like	like	ADP
dpc-5329	118	29	ad	ad	NOUN
dpc-5329	118	30	.	.	PUNCT
dpc-5329	119	1	thus	thus	ADV
dpc-5329	119	2	,	,	PUNCT
dpc-5329	119	3	the	the	DET
dpc-5329	119	4	addition	addition	NOUN
dpc-5329	119	5	of	of	ADP
dpc-5329	119	6	this	this	DET
dpc-5329	119	7	organ	organ	NOUN
dpc-5329	119	8	system	system	NOUN
dpc-5329	119	9	into	into	ADP
dpc-5329	119	10	the	the	DET
dpc-5329	119	11	singe	singe	NOUN
dpc-5329	119	12	framework	framework	NOUN
dpc-5329	119	13	strengthens	strengthen	VERB
dpc-5329	119	14	knowledge	knowledge	NOUN
dpc-5329	119	15	of	of	ADP
dpc-5329	119	16	the	the	DET
dpc-5329	119	17	disease	disease	NOUN
dpc-5329	119	18	.	.	PUNCT
dpc-5329	120	1	endocrine	endocrine	ADJ
dpc-5329	120	2	involvement	involvement	NOUN
dpc-5329	120	3	in	in	ADP
dpc-5329	120	4	ad	ad	NOUN
dpc-5329	120	5	the	the	DET
dpc-5329	120	6	endocrine	endocrine	NOUN
dpc-5329	120	7	system	system	NOUN
dpc-5329	120	8	contributes	contribute	VERB
dpc-5329	120	9	to	to	ADP
dpc-5329	120	10	the	the	DET
dpc-5329	120	11	pathophysiology	pathophysiology	NOUN
dpc-5329	120	12	of	of	ADP
dpc-5329	120	13	ad	ad	NOUN
dpc-5329	120	14	,	,	PUNCT
dpc-5329	120	15	primarily	primarily	ADV
dpc-5329	120	16	through	through	ADP
dpc-5329	120	17	the	the	DET
dpc-5329	120	18	hypothalamic	hypothalamic	ADJ
dpc-5329	120	19	-	-	PUNCT
dpc-5329	120	20	pituitary	pituitary	ADJ
dpc-5329	120	21	-	-	PUNCT
dpc-5329	120	22	adrenal	adrenal	ADJ
dpc-5329	120	23	(	(	PUNCT
dpc-5329	120	24	hpa	hpa	NOUN
dpc-5329	120	25	)	)	PUNCT
dpc-5329	120	26	axis	axis	NOUN
dpc-5329	120	27	.	.	PUNCT
dpc-5329	121	1	in	in	ADP
dpc-5329	121	2	response	response	NOUN
dpc-5329	121	3	to	to	ADP
dpc-5329	121	4	stress	stress	NOUN
dpc-5329	121	5	,	,	PUNCT
dpc-5329	121	6	this	this	DET
dpc-5329	121	7	axis	axis	NOUN
dpc-5329	121	8	activates	activate	VERB
dpc-5329	121	9	a	a	DET
dpc-5329	121	10	cascade	cascade	NOUN
dpc-5329	121	11	of	of	ADP
dpc-5329	121	12	hormonal	hormonal	ADJ
dpc-5329	121	13	responses	response	NOUN
dpc-5329	121	14	involving	involve	VERB
dpc-5329	121	15	corticotropin	corticotropin	NOUN
dpc-5329	121	16	-	-	PUNCT
dpc-5329	121	17	releasing	release	VERB
dpc-5329	121	18	hormone	hormone	NOUN
dpc-5329	121	19	(	(	PUNCT
dpc-5329	121	20	crh	crh	PROPN
dpc-5329	121	21	)	)	PUNCT
dpc-5329	121	22	and	and	CCONJ
dpc-5329	121	23	adrenocorticotropic	adrenocorticotropic	NOUN
dpc-5329	121	24	hormone	hormone	NOUN
dpc-5329	121	25	(	(	PUNCT
dpc-5329	121	26	acth	acth	NOUN
dpc-5329	121	27	)	)	PUNCT
dpc-5329	121	28	,	,	PUNCT
dpc-5329	121	29	leading	lead	VERB
dpc-5329	121	30	to	to	ADP
dpc-5329	121	31	increased	increase	VERB
dpc-5329	121	32	cortisol	cortisol	ADJ
dpc-5329	121	33	production	production	NOUN
dpc-5329	121	34	.	.	PUNCT
dpc-5329	122	1	while	while	SCONJ
dpc-5329	122	2	it	it	PRON
dpc-5329	122	3	is	be	AUX
dpc-5329	122	4	an	an	DET
dpc-5329	122	5	essential	essential	ADJ
dpc-5329	122	6	anti	anti	ADJ
dpc-5329	122	7	-	-	ADJ
dpc-5329	122	8	inflammatory	inflammatory	ADJ
dpc-5329	122	9	hormone	hormone	NOUN
dpc-5329	122	10	,	,	PUNCT
dpc-5329	122	11	in	in	ADP
dpc-5329	122	12	ad	ad	NOUN
dpc-5329	122	13	,	,	PUNCT
dpc-5329	122	14	cortisol	cortisol	NOUN
dpc-5329	122	15	paradoxically	paradoxically	ADV
dpc-5329	122	16	contributes	contribute	VERB
dpc-5329	122	17	to	to	ADP
dpc-5329	122	18	the	the	DET
dpc-5329	122	19	characteristic	characteristic	ADJ
dpc-5329	122	20	inflammation	inflammation	NOUN
dpc-5329	122	21	by	by	ADP
dpc-5329	122	22	impairing	impair	VERB
dpc-5329	122	23	keratinocyte	keratinocyte	NOUN
dpc-5329	122	24	proliferation	proliferation	NOUN
dpc-5329	122	25	and	and	CCONJ
dpc-5329	122	26	barrier	barrier	NOUN
dpc-5329	122	27	integrity	integrity	NOUN
dpc-5329	122	28	due	due	ADP
dpc-5329	122	29	to	to	ADP
dpc-5329	122	30	dysfunctional	dysfunctional	ADJ
dpc-5329	122	31	signaling	signaling	NOUN
dpc-5329	122	32	within	within	ADP
dpc-5329	122	33	the	the	DET
dpc-5329	122	34	epidermis	epidermis	NOUN
dpc-5329	123	1	[	[	X
dpc-5329	123	2	30,31	30,31	NOUN
dpc-5329	123	3	]	]	PUNCT
dpc-5329	123	4	.	.	PUNCT
dpc-5329	124	1	gastrointestinal	gastrointestinal	ADJ
dpc-5329	124	2	involvement	involvement	NOUN
dpc-5329	124	3	in	in	ADP
dpc-5329	124	4	ad	ad	NOUN
dpc-5329	124	5	the	the	DET
dpc-5329	124	6	gut	gut	NOUN
dpc-5329	124	7	-	-	PUNCT
dpc-5329	124	8	skin	skin	NOUN
dpc-5329	124	9	axis	axis	NOUN
dpc-5329	124	10	further	further	ADJ
dpc-5329	124	11	highlights	highlight	NOUN
dpc-5329	124	12	the	the	DET
dpc-5329	124	13	multisystem	multisystem	NOUN
dpc-5329	124	14	reach	reach	VERB
dpc-5329	124	15	of	of	ADP
dpc-5329	124	16	ad	ad	NOUN
dpc-5329	124	17	,	,	PUNCT
dpc-5329	124	18	with	with	ADP
dpc-5329	124	19	gut	gut	NOUN
dpc-5329	124	20	microbiota	microbiota	NOUN
dpc-5329	124	21	serving	serve	VERB
dpc-5329	124	22	a	a	DET
dpc-5329	124	23	crucial	crucial	ADJ
dpc-5329	124	24	role	role	NOUN
dpc-5329	124	25	in	in	ADP
dpc-5329	124	26	the	the	DET
dpc-5329	124	27	crosstalk	crosstalk	NOUN
dpc-5329	124	28	between	between	ADP
dpc-5329	124	29	these	these	DET
dpc-5329	124	30	organs	organ	NOUN
dpc-5329	124	31	.	.	PUNCT
dpc-5329	124	32	similar	similar	ADJ
dpc-5329	124	33	to	to	ADP
dpc-5329	124	34	the	the	DET
dpc-5329	124	35	skin	skin	NOUN
dpc-5329	124	36	microbiome	microbiome	NOUN
dpc-5329	124	37	,	,	PUNCT
dpc-5329	124	38	the	the	DET
dpc-5329	124	39	gastrointestinal	gastrointestinal	ADJ
dpc-5329	124	40	tract	tract	NOUN
dpc-5329	124	41	houses	house	NOUN
dpc-5329	124	42	a	a	DET
dpc-5329	124	43	multitude	multitude	NOUN
dpc-5329	124	44	of	of	ADP
dpc-5329	124	45	microorganisms	microorganism	NOUN
dpc-5329	124	46	and	and	CCONJ
dpc-5329	124	47	thus	thus	ADV
dpc-5329	124	48	contributes	contribute	VERB
dpc-5329	124	49	to	to	ADP
dpc-5329	124	50	the	the	DET
dpc-5329	124	51	development	development	NOUN
dpc-5329	124	52	of	of	ADP
dpc-5329	124	53	the	the	DET
dpc-5329	124	54	immune	immune	ADJ
dpc-5329	124	55	system	system	NOUN
dpc-5329	124	56	[	[	X
dpc-5329	124	57	27	27	NUM
dpc-5329	124	58	]	]	PUNCT
dpc-5329	124	59	.	.	PUNCT
dpc-5329	125	1	when	when	SCONJ
dpc-5329	125	2	disrupted	disrupt	VERB
dpc-5329	125	3	,	,	PUNCT
dpc-5329	125	4	the	the	DET
dpc-5329	125	5	gut	gut	NOUN
dpc-5329	125	6	microbiome	microbiome	NOUN
dpc-5329	125	7	demonstrates	demonstrate	VERB
dpc-5329	125	8	a	a	DET
dpc-5329	125	9	reduced	reduced	ADJ
dpc-5329	125	10	microbial	microbial	ADJ
dpc-5329	125	11	diversity	diversity	NOUN
dpc-5329	125	12	,	,	PUNCT
dpc-5329	125	13	a	a	DET
dpc-5329	125	14	decrease	decrease	NOUN
dpc-5329	125	15	in	in	ADP
dpc-5329	125	16	beneficial	beneficial	ADJ
dpc-5329	125	17	bacteria	bacteria	NOUN
dpc-5329	125	18	like	like	ADP
dpc-5329	125	19	bifidobacterium	bifidobacterium	NOUN
dpc-5329	125	20	and	and	CCONJ
dpc-5329	125	21	lactobacillus	lactobacillus	NOUN
dpc-5329	125	22	,	,	PUNCT
dpc-5329	125	23	and	and	CCONJ
dpc-5329	125	24	an	an	DET
dpc-5329	125	25	increase	increase	NOUN
dpc-5329	125	26	in	in	ADP
dpc-5329	125	27	harmful	harmful	ADJ
dpc-5329	125	28	species	specie	NOUN
dpc-5329	125	29	like	like	ADP
dpc-5329	125	30	clostridium	clostridium	NOUN
dpc-5329	125	31	difficile	difficile	ADJ
dpc-5329	125	32	and	and	CCONJ
dpc-5329	125	33	escherichia	escherichia	NOUN
dpc-5329	125	34	coli	coli	NOUN
dpc-5329	125	35	.	.	PUNCT
dpc-5329	126	1	these	these	DET
dpc-5329	126	2	changes	change	NOUN
dpc-5329	126	3	contribute	contribute	VERB
dpc-5329	126	4	to	to	ADP
dpc-5329	126	5	increased	increase	VERB
dpc-5329	126	6	gut	gut	NOUN
dpc-5329	126	7	permeability	permeability	NOUN
dpc-5329	126	8	,	,	PUNCT
dpc-5329	126	9	allowing	allow	VERB
dpc-5329	126	10	inflammatory	inflammatory	ADJ
dpc-5329	126	11	agents	agent	NOUN
dpc-5329	126	12	to	to	PART
dpc-5329	126	13	enter	enter	VERB
dpc-5329	126	14	the	the	DET
dpc-5329	126	15	systemic	systemic	ADJ
dpc-5329	126	16	circulation	circulation	NOUN
dpc-5329	126	17	and	and	CCONJ
dpc-5329	126	18	exacerbate	exacerbate	VERB
dpc-5329	126	19	skin	skin	NOUN
dpc-5329	126	20	inflammation	inflammation	NOUN
dpc-5329	126	21	[	[	X
dpc-5329	126	22	27,28	27,28	NUM
dpc-5329	126	23	]	]	X
dpc-5329	126	24	.	.	PUNCT
dpc-5329	127	1	microbial	microbial	ADJ
dpc-5329	127	2	metabolites	metabolite	NOUN
dpc-5329	127	3	play	play	VERB
dpc-5329	127	4	a	a	DET
dpc-5329	127	5	central	central	ADJ
dpc-5329	127	6	role	role	NOUN
dpc-5329	127	7	in	in	ADP
dpc-5329	127	8	the	the	DET
dpc-5329	127	9	gut	gut	NOUN
dpc-5329	127	10	-	-	PUNCT
dpc-5329	127	11	skin	skin	NOUN
dpc-5329	127	12	axis	axis	NOUN
dpc-5329	127	13	,	,	PUNCT
dpc-5329	127	14	influencing	influence	VERB
dpc-5329	127	15	immune	immune	ADJ
dpc-5329	127	16	responses	response	NOUN
dpc-5329	127	17	,	,	PUNCT
dpc-5329	127	18	neuroendocrine	neuroendocrine	NOUN
dpc-5329	127	19	-	-	PUNCT
dpc-5329	127	20	induced	induced	ADJ
dpc-5329	127	21	inflammation	inflammation	NOUN
dpc-5329	127	22	,	,	PUNCT
dpc-5329	127	23	and	and	CCONJ
dpc-5329	127	24	skin	skin	NOUN
dpc-5329	127	25	barrier	barrier	NOUN
dpc-5329	127	26	integrity	integrity	NOUN
dpc-5329	127	27	[	[	X
dpc-5329	127	28	27	27	NUM
dpc-5329	127	29	]	]	PUNCT
dpc-5329	127	30	.	.	PUNCT
dpc-5329	128	1	short	short	ADJ
dpc-5329	128	2	-	-	PUNCT
dpc-5329	128	3	chain	chain	NOUN
dpc-5329	128	4	fatty	fatty	NOUN
dpc-5329	128	5	acids	acid	NOUN
dpc-5329	128	6	(	(	PUNCT
dpc-5329	128	7	scfas	scfas	NOUN
dpc-5329	128	8	)	)	PUNCT
dpc-5329	128	9	such	such	ADJ
dpc-5329	128	10	as	as	ADP
dpc-5329	128	11	butyrate	butyrate	NOUN
dpc-5329	128	12	,	,	PUNCT
dpc-5329	128	13	acetate	acetate	NOUN
dpc-5329	128	14	,	,	PUNCT
dpc-5329	128	15	and	and	CCONJ
dpc-5329	128	16	propionate	propionate	NOUN
dpc-5329	128	17	alter	alter	VERB
dpc-5329	128	18	the	the	DET
dpc-5329	128	19	circulating	circulate	VERB
dpc-5329	128	20	levels	level	NOUN
dpc-5329	128	21	of	of	ADP
dpc-5329	128	22	neuroendocrine	neuroendocrine	ADJ
dpc-5329	128	23	and	and	CCONJ
dpc-5329	128	24	immunological	immunological	ADJ
dpc-5329	128	25	mediators	mediator	NOUN
dpc-5329	128	26	[	[	X
dpc-5329	128	27	28,29	28,29	NUM
dpc-5329	128	28	]	]	X
dpc-5329	128	29	.	.	PUNCT
dpc-5329	129	1	for	for	ADP
dpc-5329	129	2	example	example	NOUN
dpc-5329	129	3	,	,	PUNCT
dpc-5329	129	4	butyrate	butyrate	NOUN
dpc-5329	129	5	promotes	promote	VERB
dpc-5329	129	6	t	t	NOUN
dpc-5329	129	7	cell	cell	NOUN
dpc-5329	129	8	function	function	NOUN
dpc-5329	129	9	and	and	CCONJ
dpc-5329	129	10	enhances	enhance	VERB
dpc-5329	129	11	epithelial	epithelial	ADJ
dpc-5329	129	12	barrier	barrier	NOUN
dpc-5329	129	13	integrity	integrity	NOUN
dpc-5329	129	14	,	,	PUNCT
dpc-5329	129	15	altogether	altogether	ADV
dpc-5329	129	16	mitigating	mitigate	VERB
dpc-5329	129	17	inflammation	inflammation	NOUN
dpc-5329	129	18	[	[	X
dpc-5329	129	19	27	27	NUM
dpc-5329	129	20	]	]	PUNCT
dpc-5329	129	21	.	.	PUNCT
dpc-5329	130	1	microbial	microbial	ADJ
dpc-5329	130	2	dysbiosis	dysbiosis	NOUN
dpc-5329	130	3	,	,	PUNCT
dpc-5329	130	4	on	on	ADP
dpc-5329	130	5	the	the	DET
dpc-5329	130	6	other	other	ADJ
dpc-5329	130	7	hand	hand	NOUN
dpc-5329	130	8	,	,	PUNCT
dpc-5329	130	9	can	can	AUX
dpc-5329	130	10	activate	activate	VERB
dpc-5329	130	11	immune	immune	ADJ
dpc-5329	130	12	responses	response	NOUN
dpc-5329	130	13	through	through	ADP
dpc-5329	130	14	dysbiosis	dysbiosis	NOUN
dpc-5329	130	15	-	-	PUNCT
dpc-5329	130	16	associated	associate	VERB
dpc-5329	130	17	metabolites	metabolite	NOUN
dpc-5329	130	18	including	include	VERB
dpc-5329	130	19	lipopolysaccharides	lipopolysaccharide	NOUN
dpc-5329	130	20	,	,	PUNCT
dpc-5329	130	21	which	which	PRON
dpc-5329	130	22	trigger	trigger	VERB
dpc-5329	130	23	pro	pro	ADJ
dpc-5329	130	24	-	-	ADJ
dpc-5329	130	25	inflammatory	inflammatory	ADJ
dpc-5329	130	26	cytokines	cytokine	NOUN
dpc-5329	130	27	and	and	CCONJ
dpc-5329	130	28	exacerbate	exacerbate	VERB
dpc-5329	130	29	ad	ad	NOUN
dpc-5329	130	30	figure	figure	NOUN
dpc-5329	130	31	4	4	NUM
dpc-5329	130	32	.	.	PUNCT
dpc-5329	131	1	the	the	DET
dpc-5329	131	2	itch	itch	NOUN
dpc-5329	131	3	-	-	PUNCT
dpc-5329	131	4	scratch	scratch	NOUN
dpc-5329	131	5	cycle	cycle	NOUN
dpc-5329	131	6	.	.	PUNCT
dpc-5329	132	1	the	the	DET
dpc-5329	132	2	itch	itch	NOUN
dpc-5329	132	3	-	-	PUNCT
dpc-5329	132	4	scratch	scratch	NOUN
dpc-5329	132	5	cycle	cycle	NOUN
dpc-5329	132	6	perpetuates	perpetuate	VERB
dpc-5329	132	7	skin	skin	NOUN
dpc-5329	132	8	damage	damage	NOUN
dpc-5329	132	9	and	and	CCONJ
dpc-5329	132	10	inflammation	inflammation	NOUN
dpc-5329	132	11	,	,	PUNCT
dpc-5329	132	12	driving	drive	VERB
dpc-5329	132	13	the	the	DET
dpc-5329	132	14	pruritus	pruritus	NOUN
dpc-5329	132	15	seen	see	VERB
dpc-5329	132	16	in	in	ADP
dpc-5329	132	17	atopic	atopic	NOUN
dpc-5329	132	18	dermatitis	dermatitis	NOUN
dpc-5329	132	19	.	.	PUNCT
dpc-5329	133	1	the	the	DET
dpc-5329	133	2	itch	itch	NOUN
dpc-5329	133	3	sensation	sensation	NOUN
dpc-5329	133	4	triggers	trigger	VERB
dpc-5329	133	5	a	a	DET
dpc-5329	133	6	scratching	scratching	NOUN
dpc-5329	133	7	response	response	NOUN
dpc-5329	133	8	,	,	PUNCT
dpc-5329	133	9	which	which	PRON
dpc-5329	133	10	worsens	worsen	VERB
dpc-5329	133	11	inflammation	inflammation	NOUN
dpc-5329	133	12	and	and	CCONJ
dpc-5329	133	13	epidermal	epidermal	ADJ
dpc-5329	133	14	barrier	barrier	NOUN
dpc-5329	133	15	damage	damage	NOUN
dpc-5329	133	16	,	,	PUNCT
dpc-5329	133	17	further	far	ADV
dpc-5329	133	18	fueling	fuel	VERB
dpc-5329	133	19	the	the	DET
dpc-5329	133	20	cycle	cycle	NOUN
dpc-5329	133	21	.	.	PUNCT
dpc-5329	134	1	6	6	NUM
dpc-5329	134	2	review	review	NOUN
dpc-5329	134	3	|	|	ADV
dpc-5329	134	4	dermatol	dermatol	ADJ
dpc-5329	134	5	pract	pract	NOUN
dpc-5329	134	6	concept	concept	NOUN
dpc-5329	134	7	.	.	PUNCT
dpc-5329	135	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	135	2	targeting	target	VERB
dpc-5329	135	3	neuropeptides	neuropeptide	NOUN
dpc-5329	135	4	,	,	PUNCT
dpc-5329	135	5	such	such	ADJ
dpc-5329	135	6	as	as	ADP
dpc-5329	135	7	sp	sp	ADP
dpc-5329	135	8	and	and	CCONJ
dpc-5329	135	9	cgrp	cgrp	NOUN
dpc-5329	135	10	antagonists	antagonist	NOUN
dpc-5329	135	11	,	,	PUNCT
dpc-5329	135	12	are	be	AUX
dpc-5329	135	13	being	be	AUX
dpc-5329	135	14	explored	explore	VERB
dpc-5329	135	15	as	as	ADP
dpc-5329	135	16	possible	possible	ADJ
dpc-5329	135	17	approaches	approach	NOUN
dpc-5329	135	18	to	to	PART
dpc-5329	135	19	inhibit	inhibit	VERB
dpc-5329	135	20	itch	itch	NOUN
dpc-5329	135	21	and	and	CCONJ
dpc-5329	135	22	neurogenic	neurogenic	ADJ
dpc-5329	135	23	inflammation	inflammation	NOUN
dpc-5329	135	24	[	[	X
dpc-5329	135	25	40	40	NUM
dpc-5329	135	26	-	-	SYM
dpc-5329	135	27	42	42	NUM
dpc-5329	135	28	]	]	PUNCT
dpc-5329	135	29	.	.	PUNCT
dpc-5329	136	1	given	give	VERB
dpc-5329	136	2	the	the	DET
dpc-5329	136	3	role	role	NOUN
dpc-5329	136	4	of	of	ADP
dpc-5329	136	5	the	the	DET
dpc-5329	136	6	hpa	hpa	NOUN
dpc-5329	136	7	axis	axis	NOUN
dpc-5329	136	8	in	in	ADP
dpc-5329	136	9	ad	ad	NOUN
dpc-5329	136	10	exacerbations	exacerbation	NOUN
dpc-5329	136	11	,	,	PUNCT
dpc-5329	136	12	treatment	treatment	NOUN
dpc-5329	136	13	aimed	aim	VERB
dpc-5329	136	14	at	at	ADP
dpc-5329	136	15	modulating	modulate	VERB
dpc-5329	136	16	the	the	DET
dpc-5329	136	17	dysregulated	dysregulated	ADJ
dpc-5329	136	18	endogenous	endogenous	ADJ
dpc-5329	136	19	cortisol	cortisol	ADJ
dpc-5329	136	20	production	production	NOUN
dpc-5329	136	21	rather	rather	ADV
dpc-5329	136	22	than	than	ADP
dpc-5329	136	23	simply	simply	ADV
dpc-5329	136	24	supplementing	supplement	VERB
dpc-5329	136	25	with	with	ADP
dpc-5329	136	26	exogenous	exogenous	ADJ
dpc-5329	136	27	corticosteroids	corticosteroid	NOUN
dpc-5329	136	28	may	may	AUX
dpc-5329	136	29	help	help	VERB
dpc-5329	136	30	address	address	VERB
dpc-5329	136	31	stress	stress	NOUN
dpc-5329	136	32	-	-	PUNCT
dpc-5329	136	33	induced	induce	VERB
dpc-5329	136	34	flares	flare	NOUN
dpc-5329	136	35	[	[	X
dpc-5329	136	36	31,32	31,32	NUM
dpc-5329	136	37	]	]	X
dpc-5329	136	38	.	.	PUNCT
dpc-5329	137	1	along	along	ADP
dpc-5329	137	2	a	a	DET
dpc-5329	137	3	similar	similar	ADJ
dpc-5329	137	4	logic	logic	NOUN
dpc-5329	137	5	,	,	PUNCT
dpc-5329	137	6	psychosocial	psychosocial	ADJ
dpc-5329	137	7	therapies	therapy	NOUN
dpc-5329	137	8	could	could	AUX
dpc-5329	137	9	also	also	ADV
dpc-5329	137	10	mitigate	mitigate	VERB
dpc-5329	137	11	the	the	DET
dpc-5329	137	12	disease	disease	NOUN
dpc-5329	137	13	burden	burden	NOUN
dpc-5329	137	14	alongside	alongside	ADP
dpc-5329	137	15	medical	medical	ADJ
dpc-5329	137	16	treatment	treatment	NOUN
dpc-5329	138	1	[	[	X
dpc-5329	138	2	33,35	33,35	NOUN
dpc-5329	138	3	]	]	PUNCT
dpc-5329	138	4	.	.	PUNCT
dpc-5329	139	1	considering	consider	VERB
dpc-5329	139	2	the	the	DET
dpc-5329	139	3	heterogeneity	heterogeneity	NOUN
dpc-5329	139	4	of	of	ADP
dpc-5329	139	5	ad	ad	NOUN
dpc-5329	139	6	,	,	PUNCT
dpc-5329	139	7	with	with	ADP
dpc-5329	139	8	diverse	diverse	ADJ
dpc-5329	139	9	clinical	clinical	ADJ
dpc-5329	139	10	presentations	presentation	NOUN
dpc-5329	139	11	and	and	CCONJ
dpc-5329	139	12	immune	immune	ADJ
dpc-5329	139	13	profiles	profile	NOUN
dpc-5329	139	14	,	,	PUNCT
dpc-5329	139	15	future	future	ADJ
dpc-5329	139	16	research	research	NOUN
dpc-5329	139	17	should	should	AUX
dpc-5329	139	18	explore	explore	VERB
dpc-5329	139	19	targeted	target	VERB
dpc-5329	139	20	,	,	PUNCT
dpc-5329	139	21	individualized	individualized	ADJ
dpc-5329	139	22	therapies	therapy	NOUN
dpc-5329	139	23	that	that	PRON
dpc-5329	139	24	account	account	VERB
dpc-5329	139	25	for	for	ADP
dpc-5329	139	26	this	this	DET
dpc-5329	139	27	variability	variability	NOUN
dpc-5329	139	28	by	by	ADP
dpc-5329	139	29	leveraging	leverage	VERB
dpc-5329	139	30	the	the	DET
dpc-5329	139	31	multiple	multiple	ADJ
dpc-5329	139	32	systems	system	NOUN
dpc-5329	139	33	of	of	ADP
dpc-5329	139	34	the	the	DET
dpc-5329	139	35	singe	singe	NOUN
dpc-5329	139	36	network	network	NOUN
dpc-5329	139	37	to	to	PART
dpc-5329	139	38	better	well	ADV
dpc-5329	139	39	develop	develop	VERB
dpc-5329	139	40	integrative	integrative	ADJ
dpc-5329	139	41	therapies	therapy	NOUN
dpc-5329	139	42	.	.	PUNCT
dpc-5329	140	1	this	this	DET
dpc-5329	140	2	interconnected	interconnected	ADJ
dpc-5329	140	3	,	,	PUNCT
dpc-5329	140	4	holistic	holistic	ADJ
dpc-5329	140	5	approach	approach	NOUN
dpc-5329	140	6	to	to	ADP
dpc-5329	140	7	studying	study	VERB
dpc-5329	140	8	ad	ad	NOUN
dpc-5329	140	9	paves	pave	VERB
dpc-5329	140	10	the	the	DET
dpc-5329	140	11	way	way	NOUN
dpc-5329	140	12	for	for	ADP
dpc-5329	140	13	innovation	innovation	NOUN
dpc-5329	140	14	that	that	PRON
dpc-5329	140	15	could	could	AUX
dpc-5329	140	16	improve	improve	VERB
dpc-5329	140	17	patient	patient	ADJ
dpc-5329	140	18	outcomes	outcome	NOUN
dpc-5329	140	19	and	and	CCONJ
dpc-5329	140	20	quality	quality	NOUN
dpc-5329	140	21	of	of	ADP
dpc-5329	140	22	life	life	NOUN
dpc-5329	140	23	.	.	PUNCT
dpc-5329	141	1	references	reference	NOUN
dpc-5329	141	2	1	1	NUM
dpc-5329	141	3	.	.	PUNCT
dpc-5329	141	4	afshari	afshari	PROPN
dpc-5329	141	5	m	m	PROPN
dpc-5329	141	6	,	,	PUNCT
dpc-5329	141	7	kolackova	kolackova	PROPN
dpc-5329	141	8	m	m	PROPN
dpc-5329	141	9	,	,	PUNCT
dpc-5329	141	10	rosecka	rosecka	PROPN
dpc-5329	141	11	m	m	PROPN
dpc-5329	141	12	,	,	PUNCT
dpc-5329	141	13	čelakovská	čelakovská	PROPN
dpc-5329	141	14	j	j	PROPN
dpc-5329	141	15	,	,	PUNCT
dpc-5329	141	16	krejsek	krejsek	PROPN
dpc-5329	141	17	j.	j.	PROPN
dpc-5329	141	18	unraveling	unravel	VERB
dpc-5329	141	19	the	the	DET
dpc-5329	141	20	skin	skin	NOUN
dpc-5329	141	21	;	;	PUNCT
dpc-5329	141	22	a	a	DET
dpc-5329	141	23	comprehensive	comprehensive	ADJ
dpc-5329	141	24	review	review	NOUN
dpc-5329	141	25	of	of	ADP
dpc-5329	141	26	atopic	atopic	NOUN
dpc-5329	141	27	dermatitis	dermatitis	NOUN
dpc-5329	141	28	,	,	PUNCT
dpc-5329	141	29	current	current	ADJ
dpc-5329	141	30	understanding	understanding	NOUN
dpc-5329	141	31	,	,	PUNCT
dpc-5329	141	32	and	and	CCONJ
dpc-5329	141	33	approaches	approach	NOUN
dpc-5329	141	34	.	.	PUNCT
dpc-5329	142	1	frontiers	frontier	NOUN
dpc-5329	142	2	in	in	ADP
dpc-5329	142	3	immunology	immunology	NOUN
dpc-5329	142	4	.	.	PUNCT
dpc-5329	143	1	2024;15	2024;15	X
dpc-5329	143	2	.	.	PUNCT
dpc-5329	143	3	doi:10.3389	doi:10.3389	PROPN
dpc-5329	143	4	/	/	SYM
dpc-5329	143	5	fimmu.2024.1361005	fimmu.2024.1361005	PROPN
dpc-5329	143	6	.	.	PUNCT
dpc-5329	144	1	pmid	pmid	NOUN
dpc-5329	144	2	:	:	PUNCT
dpc-5329	144	3	38500882	38500882	NUM
dpc-5329	144	4	2	2	NUM
dpc-5329	144	5	.	.	PUNCT
dpc-5329	145	1	kolb	kolb	PROPN
dpc-5329	145	2	l	l	PROPN
dpc-5329	145	3	,	,	PUNCT
dpc-5329	145	4	ferrer	ferrer	PROPN
dpc-5329	145	5	-	-	PUNCT
dpc-5329	145	6	bruker	bruker	ADJ
dpc-5329	145	7	sj	sj	PROPN
dpc-5329	145	8	.	.	PUNCT
dpc-5329	145	9	atopic	atopic	PROPN
dpc-5329	145	10	dermatitis	dermatitis	PROPN
dpc-5329	145	11	.	.	PUNCT
dpc-5329	146	1	in	in	ADP
dpc-5329	146	2	:	:	PUNCT
dpc-5329	146	3	statpearls	statpearl	NOUN
dpc-5329	146	4	.	.	PUNCT
dpc-5329	147	1	statpearls	statpearls	PROPN
dpc-5329	147	2	publishing	publishing	NOUN
dpc-5329	147	3	;	;	PUNCT
dpc-5329	147	4	2024	2024	NUM
dpc-5329	147	5	.	.	PUNCT
dpc-5329	148	1	pmid	pmid	NOUN
dpc-5329	148	2	:	:	PUNCT
dpc-5329	148	3	28846349	28846349	NUM
dpc-5329	148	4	3	3	X
dpc-5329	148	5	.	.	PUNCT
dpc-5329	148	6	magnifico	magnifico	PROPN
dpc-5329	149	1	i	i	PROPN
dpc-5329	149	2	,	,	PUNCT
dpc-5329	149	3	petronio	petronio	ADJ
dpc-5329	149	4	petronio	petronio	NOUN
dpc-5329	149	5	g	g	PROPN
dpc-5329	149	6	,	,	PUNCT
dpc-5329	149	7	venditti	venditti	PROPN
dpc-5329	149	8	n	n	CCONJ
dpc-5329	149	9	,	,	PUNCT
dpc-5329	149	10	et	et	PROPN
dpc-5329	149	11	al	al	PROPN
dpc-5329	149	12	.	.	PUNCT
dpc-5329	150	1	atopic	atopic	PROPN
dpc-5329	150	2	dermatitis	dermatitis	PROPN
dpc-5329	150	3	as	as	ADP
dpc-5329	150	4	a	a	DET
dpc-5329	150	5	multifactorial	multifactorial	ADJ
dpc-5329	150	6	skin	skin	NOUN
dpc-5329	150	7	disorder	disorder	NOUN
dpc-5329	150	8	.	.	PUNCT
dpc-5329	151	1	can	can	AUX
dpc-5329	151	2	the	the	DET
dpc-5329	151	3	analysis	analysis	NOUN
dpc-5329	151	4	of	of	ADP
dpc-5329	151	5	pathophysiological	pathophysiological	ADJ
dpc-5329	151	6	targets	target	NOUN
dpc-5329	151	7	represent	represent	VERB
dpc-5329	151	8	the	the	DET
dpc-5329	151	9	winning	win	VERB
dpc-5329	151	10	therapeutic	therapeutic	ADJ
dpc-5329	151	11	mistrategy	mistrategy	NOUN
dpc-5329	151	12	?	?	PUNCT
dpc-5329	152	1	pharmaceuticals	pharmaceutical	NOUN
dpc-5329	152	2	(	(	PUNCT
dpc-5329	152	3	basel	basel	PROPN
dpc-5329	152	4	)	)	PUNCT
dpc-5329	152	5	.	.	PUNCT
dpc-5329	153	1	2020;13(11):411	2020;13(11):411	X
dpc-5329	153	2	.	.	PUNCT
dpc-5329	154	1	doi:10.3390	doi:10.3390	PROPN
dpc-5329	154	2	/	/	SYM
dpc-5329	154	3	ph13110411	ph13110411	PROPN
dpc-5329	154	4	.	.	PUNCT
dpc-5329	155	1	pmid	pmid	NOUN
dpc-5329	155	2	:	:	PUNCT
dpc-5329	155	3	33266440	33266440	NUM
dpc-5329	155	4	4	4	NUM
dpc-5329	155	5	.	.	PUNCT
dpc-5329	155	6	savva	savva	PROPN
dpc-5329	155	7	m	m	PROPN
dpc-5329	155	8	,	,	PUNCT
dpc-5329	155	9	papadopoulos	papadopoulos	PROPN
dpc-5329	155	10	ng	ng	PROPN
dpc-5329	155	11	,	,	PUNCT
dpc-5329	155	12	gregoriou	gregoriou	NOUN
dpc-5329	155	13	s	s	PROPN
dpc-5329	155	14	,	,	PUNCT
dpc-5329	155	15	et	et	PROPN
dpc-5329	155	16	al	al	PROPN
dpc-5329	155	17	.	.	PUNCT
dpc-5329	156	1	recent	recent	ADJ
dpc-5329	156	2	advancements	advancement	NOUN
dpc-5329	156	3	in	in	ADP
dpc-5329	156	4	the	the	DET
dpc-5329	156	5	atopic	atopic	NOUN
dpc-5329	156	6	dermatitis	dermatitis	NOUN
dpc-5329	156	7	mechanism	mechanism	NOUN
dpc-5329	156	8	.	.	PUNCT
dpc-5329	157	1	fbl	fbl	NOUN
dpc-5329	157	2	.	.	PUNCT
dpc-5329	158	1	2024;29(2):84	2024;29(2):84	X
dpc-5329	158	2	.	.	PUNCT
dpc-5329	159	1	doi:10.31083	doi:10.31083	PROPN
dpc-5329	159	2	/	/	SYM
dpc-5329	159	3	j.fbl2902084	j.fbl2902084	PROPN
dpc-5329	159	4	5	5	NUM
dpc-5329	159	5	.	.	PUNCT
dpc-5329	159	6	weidinger	weidinger	PROPN
dpc-5329	159	7	s	s	PROPN
dpc-5329	159	8	,	,	PUNCT
dpc-5329	159	9	novak	novak	PROPN
dpc-5329	159	10	n.	n.	PROPN
dpc-5329	159	11	atopic	atopic	PROPN
dpc-5329	159	12	dermatitis	dermatitis	PROPN
dpc-5329	159	13	.	.	PUNCT
dpc-5329	160	1	the	the	DET
dpc-5329	160	2	lancet	lancet	PROPN
dpc-5329	160	3	.	.	PUNCT
dpc-5329	161	1	2016;387(10023):1109	2016;387(10023):1109	NUM
dpc-5329	161	2	-	-	SYM
dpc-5329	161	3	1122	1122	NUM
dpc-5329	161	4	.	.	PUNCT
dpc-5329	162	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	162	2	/	/	SYM
dpc-5329	162	3	s0140	s0140	PROPN
dpc-5329	162	4	-	-	PUNCT
dpc-5329	162	5	6736(15	6736(15	NUM
dpc-5329	162	6	)	)	PUNCT
dpc-5329	162	7	00149	00149	NUM
dpc-5329	162	8	-	-	SYM
dpc-5329	162	9	x	x	SYM
dpc-5329	162	10	6	6	NUM
dpc-5329	162	11	.	.	PUNCT
dpc-5329	163	1	o’sullivan	o’sullivan	NOUN
dpc-5329	163	2	rl	rl	PROPN
dpc-5329	163	3	,	,	PUNCT
dpc-5329	163	4	lipper	lipper	PROPN
dpc-5329	163	5	g	g	PROPN
dpc-5329	163	6	,	,	PUNCT
dpc-5329	163	7	lerner	lerner	PROPN
dpc-5329	163	8	ea	ea	PROPN
dpc-5329	163	9	.	.	PUNCT
dpc-5329	164	1	the	the	DET
dpc-5329	164	2	neuro	neuro	PROPN
dpc-5329	164	3	immuno	immuno	PROPN
dpc-5329	164	4	-	-	PUNCT
dpc-5329	164	5	cutaneous	cutaneous	ADJ
dpc-5329	164	6	-	-	PUNCT
dpc-5329	164	7	endocrine	endocrine	NOUN
dpc-5329	164	8	network	network	NOUN
dpc-5329	164	9	:	:	PUNCT
dpc-5329	164	10	relationship	relationship	NOUN
dpc-5329	164	11	of	of	ADP
dpc-5329	164	12	mind	mind	NOUN
dpc-5329	164	13	and	and	CCONJ
dpc-5329	164	14	skin	skin	NOUN
dpc-5329	164	15	.	.	PUNCT
dpc-5329	165	1	archives	archive	NOUN
dpc-5329	165	2	of	of	ADP
dpc-5329	165	3	dermatology	dermatology	NOUN
dpc-5329	165	4	.	.	PUNCT
dpc-5329	166	1	1998;134(11	1998;134(11	NOUN
dpc-5329	166	2	):	):	PUNCT
dpc-5329	166	3	1431	1431	NUM
dpc-5329	166	4	-	-	SYM
dpc-5329	166	5	1435	1435	NUM
dpc-5329	166	6	.	.	PUNCT
dpc-5329	167	1	doi:10.1001	doi:10.1001	PROPN
dpc-5329	167	2	/	/	SYM
dpc-5329	167	3	archderm.134.11.1431	archderm.134.11.1431	PROPN
dpc-5329	167	4	7	7	NUM
dpc-5329	167	5	.	.	PUNCT
dpc-5329	167	6	makowska	makowska	PROPN
dpc-5329	167	7	k	k	PROPN
dpc-5329	167	8	,	,	PUNCT
dpc-5329	167	9	nowaczyk	nowaczyk	PROPN
dpc-5329	167	10	j	j	PROPN
dpc-5329	167	11	,	,	PUNCT
dpc-5329	167	12	blicharz	blicharz	PROPN
dpc-5329	167	13	l	l	PROPN
dpc-5329	167	14	,	,	PUNCT
dpc-5329	167	15	et	et	PROPN
dpc-5329	167	16	al	al	PROPN
dpc-5329	167	17	.	.	PROPN
dpc-5329	167	18	immunopathogenesis	immunopathogenesis	NOUN
dpc-5329	167	19	of	of	ADP
dpc-5329	167	20	atopic	atopic	NOUN
dpc-5329	167	21	dermatitis	dermatitis	NOUN
dpc-5329	167	22	:	:	PUNCT
dpc-5329	167	23	focus	focus	VERB
dpc-5329	167	24	on	on	ADP
dpc-5329	167	25	interleukins	interleukin	NOUN
dpc-5329	167	26	as	as	ADP
dpc-5329	167	27	disease	disease	NOUN
dpc-5329	167	28	drivers	driver	NOUN
dpc-5329	167	29	and	and	CCONJ
dpc-5329	167	30	therapeutic	therapeutic	ADJ
dpc-5329	167	31	targets	target	NOUN
dpc-5329	167	32	for	for	ADP
dpc-5329	167	33	novel	novel	ADJ
dpc-5329	167	34	treatments	treatment	NOUN
dpc-5329	167	35	.	.	PUNCT
dpc-5329	168	1	int	int	PROPN
dpc-5329	168	2	j	j	PROPN
dpc-5329	168	3	mol	mol	ADP
dpc-5329	168	4	sci	sci	PROPN
dpc-5329	168	5	.	.	PUNCT
dpc-5329	169	1	2023;24(1):781	2023;24(1):781	NUM
dpc-5329	169	2	.	.	PUNCT
dpc-5329	170	1	doi:10.3390	doi:10.3390	NOUN
dpc-5329	170	2	/	/	SYM
dpc-5329	170	3	ijms24010781	ijms24010781	PROPN
dpc-5329	170	4	.	.	PUNCT
dpc-5329	171	1	pmid	pmid	NOUN
dpc-5329	171	2	:	:	PUNCT
dpc-5329	171	3	36614224	36614224	NUM
dpc-5329	171	4	8	8	NUM
dpc-5329	171	5	.	.	PUNCT
dpc-5329	172	1	steinhoff	steinhoff	PROPN
dpc-5329	172	2	m	m	PROPN
dpc-5329	172	3	,	,	PUNCT
dpc-5329	172	4	ahmad	ahmad	PROPN
dpc-5329	172	5	f	f	PROPN
dpc-5329	172	6	,	,	PUNCT
dpc-5329	172	7	pandey	pandey	PROPN
dpc-5329	172	8	a	a	PROPN
dpc-5329	172	9	,	,	PUNCT
dpc-5329	172	10	et	et	PROPN
dpc-5329	172	11	al	al	PROPN
dpc-5329	172	12	.	.	PROPN
dpc-5329	172	13	neuroimmune	neuroimmune	PROPN
dpc-5329	172	14	communication	communication	NOUN
dpc-5329	172	15	regulating	regulate	VERB
dpc-5329	172	16	pruritus	pruritus	NOUN
dpc-5329	172	17	in	in	ADP
dpc-5329	172	18	atopic	atopic	NOUN
dpc-5329	172	19	dermatitis	dermatitis	NOUN
dpc-5329	172	20	.	.	PUNCT
dpc-5329	173	1	journal	journal	PROPN
dpc-5329	173	2	of	of	ADP
dpc-5329	173	3	allergy	allergy	NOUN
dpc-5329	173	4	and	and	CCONJ
dpc-5329	173	5	clinical	clinical	ADJ
dpc-5329	173	6	immunology	immunology	NOUN
dpc-5329	173	7	.	.	PUNCT
dpc-5329	174	1	2022;149(6):1875	2022;149(6):1875	NUM
dpc-5329	174	2	-	-	SYM
dpc-5329	174	3	1898	1898	NUM
dpc-5329	174	4	.	.	PUNCT
dpc-5329	175	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	175	2	/	/	SYM
dpc-5329	175	3	j.jaci.2022.03.010	j.jaci.2022.03.010	PROPN
dpc-5329	175	4	9	9	NUM
dpc-5329	175	5	.	.	PUNCT
dpc-5329	175	6	lee	lee	PROPN
dpc-5329	175	7	sy	sy	PROPN
dpc-5329	175	8	,	,	PUNCT
dpc-5329	175	9	lee	lee	PROPN
dpc-5329	175	10	e	e	PROPN
dpc-5329	175	11	,	,	PUNCT
dpc-5329	175	12	park	park	PROPN
dpc-5329	175	13	ym	ym	PROPN
dpc-5329	175	14	,	,	PUNCT
dpc-5329	175	15	hong	hong	PROPN
dpc-5329	175	16	sj	sj	PROPN
dpc-5329	175	17	.	.	PUNCT
dpc-5329	175	18	microbiome	microbiome	PROPN
dpc-5329	175	19	in	in	ADP
dpc-5329	175	20	the	the	DET
dpc-5329	175	21	gutskin	gutskin	NOUN
dpc-5329	175	22	axis	axis	NOUN
dpc-5329	175	23	in	in	ADP
dpc-5329	175	24	atopic	atopic	NOUN
dpc-5329	175	25	dermatitis	dermatitis	NOUN
dpc-5329	175	26	.	.	PUNCT
dpc-5329	176	1	allergy	allergy	PROPN
dpc-5329	176	2	asthma	asthma	PROPN
dpc-5329	176	3	immunol	immunol	PROPN
dpc-5329	176	4	res	re	NOUN
dpc-5329	176	5	.	.	PUNCT
dpc-5329	177	1	2018;10(4):354	2018;10(4):354	PROPN
dpc-5329	177	2	-	-	SYM
dpc-5329	177	3	362	362	NUM
dpc-5329	177	4	.	.	PUNCT
dpc-5329	178	1	doi:10.4168	doi:10.4168	NOUN
dpc-5329	178	2	/	/	SYM
dpc-5329	178	3	aair.2018.10.4.354	aair.2018.10.4.354	NOUN
dpc-5329	178	4	.	.	PUNCT
dpc-5329	179	1	pmid	pmid	NOUN
dpc-5329	179	2	:	:	PUNCT
dpc-5329	179	3	29949831	29949831	NUM
dpc-5329	179	4	10	10	NUM
dpc-5329	179	5	.	.	PUNCT
dpc-5329	180	1	brunner	brunner	PROPN
dpc-5329	180	2	pm	pm	PROPN
dpc-5329	180	3	,	,	PUNCT
dpc-5329	180	4	guttman	guttman	ADJ
dpc-5329	180	5	-	-	PUNCT
dpc-5329	180	6	yassky	yassky	NOUN
dpc-5329	180	7	e	e	NOUN
dpc-5329	180	8	,	,	PUNCT
dpc-5329	180	9	leung	leung	PROPN
dpc-5329	180	10	dym	dym	PROPN
dpc-5329	180	11	.	.	PUNCT
dpc-5329	181	1	the	the	DET
dpc-5329	181	2	immunology	immunology	NOUN
dpc-5329	181	3	of	of	ADP
dpc-5329	181	4	ad	ad	NOUN
dpc-5329	181	5	and	and	CCONJ
dpc-5329	181	6	its	its	PRON
dpc-5329	181	7	reversibility	reversibility	NOUN
dpc-5329	181	8	with	with	ADP
dpc-5329	181	9	broad	broad	ADJ
dpc-5329	181	10	spectrum	spectrum	NOUN
dpc-5329	181	11	and	and	CCONJ
dpc-5329	181	12	targeted	target	VERB
dpc-5329	181	13	additionally	additionally	ADV
dpc-5329	181	14	,	,	PUNCT
dpc-5329	181	15	the	the	DET
dpc-5329	181	16	skin	skin	NOUN
dpc-5329	181	17	has	have	AUX
dpc-5329	181	18	developed	develop	VERB
dpc-5329	181	19	a	a	DET
dpc-5329	181	20	local	local	ADJ
dpc-5329	181	21	hpa	hpa	NOUN
dpc-5329	181	22	axis	axis	NOUN
dpc-5329	181	23	,	,	PUNCT
dpc-5329	181	24	which	which	PRON
dpc-5329	181	25	functions	function	VERB
dpc-5329	181	26	similarly	similarly	ADV
dpc-5329	181	27	to	to	ADP
dpc-5329	181	28	the	the	DET
dpc-5329	181	29	central	central	ADJ
dpc-5329	181	30	system	system	NOUN
dpc-5329	181	31	.	.	PUNCT
dpc-5329	182	1	by	by	ADP
dpc-5329	182	2	producing	produce	VERB
dpc-5329	182	3	crh	crh	PROPN
dpc-5329	182	4	,	,	PUNCT
dpc-5329	182	5	acth	acth	NOUN
dpc-5329	182	6	,	,	PUNCT
dpc-5329	182	7	and	and	CCONJ
dpc-5329	182	8	cortisol	cortisol	ADJ
dpc-5329	182	9	independently	independently	ADV
dpc-5329	182	10	,	,	PUNCT
dpc-5329	182	11	this	this	DET
dpc-5329	182	12	peripheral	peripheral	ADJ
dpc-5329	182	13	axis	axis	NOUN
dpc-5329	182	14	enables	enable	VERB
dpc-5329	182	15	a	a	DET
dpc-5329	182	16	rapid	rapid	ADJ
dpc-5329	182	17	response	response	NOUN
dpc-5329	182	18	to	to	ADP
dpc-5329	182	19	stress	stress	NOUN
dpc-5329	182	20	,	,	PUNCT
dpc-5329	182	21	crucial	crucial	ADJ
dpc-5329	182	22	for	for	ADP
dpc-5329	182	23	the	the	DET
dpc-5329	182	24	skin	skin	NOUN
dpc-5329	182	25	’s	’s	PART
dpc-5329	182	26	role	role	NOUN
dpc-5329	182	27	in	in	ADP
dpc-5329	182	28	defense	defense	NOUN
dpc-5329	182	29	against	against	ADP
dpc-5329	182	30	external	external	ADJ
dpc-5329	182	31	stressors	stressor	NOUN
dpc-5329	182	32	[	[	X
dpc-5329	182	33	32	32	NUM
dpc-5329	182	34	]	]	PUNCT
dpc-5329	182	35	.	.	PUNCT
dpc-5329	183	1	in	in	ADP
dpc-5329	183	2	the	the	DET
dpc-5329	183	3	context	context	NOUN
dpc-5329	183	4	of	of	ADP
dpc-5329	183	5	ad	ad	NOUN
dpc-5329	183	6	,	,	PUNCT
dpc-5329	183	7	the	the	DET
dpc-5329	183	8	regulatory	regulatory	ADJ
dpc-5329	183	9	function	function	NOUN
dpc-5329	183	10	of	of	ADP
dpc-5329	183	11	both	both	CCONJ
dpc-5329	183	12	the	the	DET
dpc-5329	183	13	central	central	ADJ
dpc-5329	183	14	and	and	CCONJ
dpc-5329	183	15	local	local	ADJ
dpc-5329	183	16	hpa	hpa	NOUN
dpc-5329	183	17	axis	axis	NOUN
dpc-5329	183	18	is	be	AUX
dpc-5329	183	19	disrupted	disrupt	VERB
dpc-5329	183	20	,	,	PUNCT
dpc-5329	183	21	exacerbating	exacerbate	VERB
dpc-5329	183	22	the	the	DET
dpc-5329	183	23	vicious	vicious	ADJ
dpc-5329	183	24	cycle	cycle	NOUN
dpc-5329	183	25	of	of	ADP
dpc-5329	183	26	the	the	DET
dpc-5329	183	27	disease	disease	NOUN
dpc-5329	183	28	.	.	PUNCT
dpc-5329	184	1	chronic	chronic	ADJ
dpc-5329	184	2	stress	stress	NOUN
dpc-5329	184	3	from	from	ADP
dpc-5329	184	4	physical	physical	ADJ
dpc-5329	184	5	discomfort	discomfort	NOUN
dpc-5329	184	6	,	,	PUNCT
dpc-5329	184	7	psychological	psychological	ADJ
dpc-5329	184	8	challenges	challenge	NOUN
dpc-5329	184	9	,	,	PUNCT
dpc-5329	184	10	and	and	CCONJ
dpc-5329	184	11	environmental	environmental	ADJ
dpc-5329	184	12	triggers	trigger	NOUN
dpc-5329	184	13	further	far	ADV
dpc-5329	184	14	impairs	impair	VERB
dpc-5329	184	15	the	the	DET
dpc-5329	184	16	hpa	hpa	NOUN
dpc-5329	184	17	axis	axis	NOUN
dpc-5329	184	18	function	function	NOUN
dpc-5329	184	19	[	[	X
dpc-5329	184	20	33	33	NUM
dpc-5329	184	21	-	-	SYM
dpc-5329	184	22	35	35	NUM
dpc-5329	184	23	]	]	PUNCT
dpc-5329	184	24	.	.	PUNCT
dpc-5329	185	1	this	this	PRON
dpc-5329	185	2	leads	lead	VERB
dpc-5329	185	3	to	to	ADP
dpc-5329	185	4	dysfunctional	dysfunctional	ADJ
dpc-5329	185	5	cortisol	cortisol	NOUN
dpc-5329	185	6	signaling	signal	VERB
dpc-5329	185	7	,	,	PUNCT
dpc-5329	185	8	which	which	PRON
dpc-5329	185	9	fails	fail	VERB
dpc-5329	185	10	to	to	PART
dpc-5329	185	11	suppress	suppress	VERB
dpc-5329	185	12	systemic	systemic	ADJ
dpc-5329	185	13	inflammation	inflammation	NOUN
dpc-5329	185	14	and	and	CCONJ
dpc-5329	185	15	contributes	contribute	VERB
dpc-5329	185	16	to	to	ADP
dpc-5329	185	17	the	the	DET
dpc-5329	185	18	barrier	barrier	NOUN
dpc-5329	185	19	disruption	disruption	NOUN
dpc-5329	185	20	[	[	X
dpc-5329	185	21	32,36	32,36	NUM
dpc-5329	185	22	]	]	X
dpc-5329	185	23	.	.	PUNCT
dpc-5329	186	1	the	the	DET
dpc-5329	186	2	resulting	result	VERB
dpc-5329	186	3	compromised	compromise	VERB
dpc-5329	186	4	barrier	barrier	NOUN
dpc-5329	186	5	perpetuates	perpetuate	VERB
dpc-5329	186	6	the	the	DET
dpc-5329	186	7	underlying	underlie	VERB
dpc-5329	186	8	ad	ad	NOUN
dpc-5329	186	9	pathophysiology	pathophysiology	NOUN
dpc-5329	186	10	,	,	PUNCT
dpc-5329	186	11	underscoring	underscore	VERB
dpc-5329	186	12	the	the	DET
dpc-5329	186	13	complexity	complexity	NOUN
dpc-5329	186	14	of	of	ADP
dpc-5329	186	15	this	this	DET
dpc-5329	186	16	disease	disease	NOUN
dpc-5329	186	17	.	.	PUNCT
dpc-5329	187	1	conclusion	conclusion	NOUN
dpc-5329	187	2	the	the	DET
dpc-5329	187	3	pathophysiology	pathophysiology	NOUN
dpc-5329	187	4	of	of	ADP
dpc-5329	187	5	ad	ad	NOUN
dpc-5329	187	6	reveals	reveal	VERB
dpc-5329	187	7	its	its	PRON
dpc-5329	187	8	multifactorial	multifactorial	ADJ
dpc-5329	187	9	nature	nature	NOUN
dpc-5329	187	10	and	and	CCONJ
dpc-5329	187	11	is	be	AUX
dpc-5329	187	12	best	well	ADV
dpc-5329	187	13	understood	understand	VERB
dpc-5329	187	14	through	through	ADP
dpc-5329	187	15	the	the	DET
dpc-5329	187	16	singe	singe	NOUN
dpc-5329	187	17	network	network	NOUN
dpc-5329	187	18	,	,	PUNCT
dpc-5329	187	19	which	which	PRON
dpc-5329	187	20	includes	include	VERB
dpc-5329	187	21	elements	element	NOUN
dpc-5329	187	22	such	such	ADJ
dpc-5329	187	23	as	as	ADP
dpc-5329	187	24	skin	skin	NOUN
dpc-5329	187	25	barrier	barrier	NOUN
dpc-5329	187	26	dysfunction	dysfunction	NOUN
dpc-5329	187	27	,	,	PUNCT
dpc-5329	187	28	immune	immune	ADJ
dpc-5329	187	29	dysregulation	dysregulation	NOUN
dpc-5329	187	30	,	,	PUNCT
dpc-5329	187	31	neuropeptide	neuropeptide	NOUN
dpc-5329	187	32	involvement	involvement	NOUN
dpc-5329	187	33	,	,	PUNCT
dpc-5329	187	34	gut	gut	VERB
dpc-5329	187	35	microbiota	microbiota	NOUN
dpc-5329	187	36	contributions	contribution	NOUN
dpc-5329	187	37	,	,	PUNCT
dpc-5329	187	38	and	and	CCONJ
dpc-5329	187	39	the	the	DET
dpc-5329	187	40	endocrine	endocrine	ADJ
dpc-5329	187	41	stress	stress	NOUN
dpc-5329	187	42	axes	axis	NOUN
dpc-5329	187	43	.	.	PUNCT
dpc-5329	188	1	while	while	SCONJ
dpc-5329	188	2	each	each	DET
dpc-5329	188	3	component	component	NOUN
dpc-5329	188	4	uniquely	uniquely	ADV
dpc-5329	188	5	contributes	contribute	VERB
dpc-5329	188	6	to	to	ADP
dpc-5329	188	7	the	the	DET
dpc-5329	188	8	disease	disease	NOUN
dpc-5329	188	9	,	,	PUNCT
dpc-5329	188	10	examining	examine	VERB
dpc-5329	188	11	them	they	PRON
dpc-5329	188	12	as	as	ADP
dpc-5329	188	13	a	a	DET
dpc-5329	188	14	whole	whole	ADJ
dpc-5329	188	15	highlights	highlight	NOUN
dpc-5329	188	16	their	their	PRON
dpc-5329	188	17	interdependent	interdependent	ADJ
dpc-5329	188	18	and	and	CCONJ
dpc-5329	188	19	synergistic	synergistic	ADJ
dpc-5329	188	20	impact	impact	NOUN
dpc-5329	188	21	,	,	PUNCT
dpc-5329	188	22	providing	provide	VERB
dpc-5329	188	23	a	a	DET
dpc-5329	188	24	more	more	ADV
dpc-5329	188	25	comprehensive	comprehensive	ADJ
dpc-5329	188	26	understanding	understanding	NOUN
dpc-5329	188	27	of	of	ADP
dpc-5329	188	28	ad	ad	NOUN
dpc-5329	188	29	and	and	CCONJ
dpc-5329	188	30	informing	inform	VERB
dpc-5329	188	31	therapeutic	therapeutic	ADJ
dpc-5329	188	32	targets	target	NOUN
dpc-5329	188	33	.	.	PUNCT
dpc-5329	189	1	current	current	ADJ
dpc-5329	189	2	therapies	therapy	NOUN
dpc-5329	189	3	for	for	ADP
dpc-5329	189	4	ad	ad	NOUN
dpc-5329	189	5	typically	typically	ADV
dpc-5329	189	6	target	target	VERB
dpc-5329	189	7	individual	individual	ADJ
dpc-5329	189	8	elements	element	NOUN
dpc-5329	189	9	of	of	ADP
dpc-5329	189	10	the	the	DET
dpc-5329	189	11	singe	singe	NOUN
dpc-5329	189	12	network	network	NOUN
dpc-5329	189	13	.	.	PUNCT
dpc-5329	190	1	preventative	preventative	ADJ
dpc-5329	190	2	measures	measure	NOUN
dpc-5329	190	3	include	include	VERB
dpc-5329	190	4	trigger	trigger	NOUN
dpc-5329	190	5	avoidance	avoidance	NOUN
dpc-5329	190	6	,	,	PUNCT
dpc-5329	190	7	moisturizer	moisturizer	NOUN
dpc-5329	190	8	use	use	NOUN
dpc-5329	190	9	,	,	PUNCT
dpc-5329	190	10	and	and	CCONJ
dpc-5329	190	11	gentle	gentle	ADJ
dpc-5329	190	12	bathing	bathing	NOUN
dpc-5329	190	13	[	[	X
dpc-5329	190	14	2,37,38	2,37,38	NUM
dpc-5329	190	15	]	]	PUNCT
dpc-5329	190	16	.	.	PUNCT
dpc-5329	191	1	other	other	ADJ
dpc-5329	191	2	common	common	ADJ
dpc-5329	191	3	treatments	treatment	NOUN
dpc-5329	191	4	include	include	VERB
dpc-5329	191	5	topical	topical	ADJ
dpc-5329	191	6	corticosteroids	corticosteroid	NOUN
dpc-5329	191	7	,	,	PUNCT
dpc-5329	191	8	phosphodiesterase	phosphodiesterase	NOUN
dpc-5329	191	9	inhibitors	inhibitor	NOUN
dpc-5329	191	10	,	,	PUNCT
dpc-5329	191	11	and	and	CCONJ
dpc-5329	191	12	calcineurin	calcineurin	ADJ
dpc-5329	191	13	inhibitors	inhibitor	NOUN
dpc-5329	191	14	for	for	ADP
dpc-5329	191	15	flares	flare	NOUN
dpc-5329	191	16	as	as	ADV
dpc-5329	191	17	well	well	ADV
dpc-5329	191	18	as	as	ADP
dpc-5329	191	19	ultraviolet	ultraviolet	ADJ
dpc-5329	191	20	phototherapy	phototherapy	NOUN
dpc-5329	191	21	and	and	CCONJ
dpc-5329	191	22	systemic	systemic	ADJ
dpc-5329	191	23	immunomodulators	immunomodulator	NOUN
dpc-5329	191	24	for	for	ADP
dpc-5329	191	25	severe	severe	ADJ
dpc-5329	191	26	presentations	presentation	NOUN
dpc-5329	191	27	[	[	X
dpc-5329	191	28	2,38	2,38	X
dpc-5329	191	29	]	]	X
dpc-5329	191	30	.	.	PUNCT
dpc-5329	192	1	systemic	systemic	ADJ
dpc-5329	192	2	treatment	treatment	NOUN
dpc-5329	192	3	for	for	ADP
dpc-5329	192	4	ad	ad	NOUN
dpc-5329	192	5	includes	include	VERB
dpc-5329	192	6	biologic	biologic	NOUN
dpc-5329	192	7	agents	agent	NOUN
dpc-5329	192	8	such	such	ADJ
dpc-5329	192	9	as	as	ADP
dpc-5329	192	10	dupilumab	dupilumab	NOUN
dpc-5329	192	11	,	,	PUNCT
dpc-5329	192	12	which	which	PRON
dpc-5329	192	13	inhibits	inhibit	VERB
dpc-5329	192	14	both	both	DET
dpc-5329	192	15	il-4	il-4	X
dpc-5329	192	16	and	and	CCONJ
dpc-5329	192	17	il-13	il-13	NUM
dpc-5329	192	18	,	,	PUNCT
dpc-5329	192	19	and	and	CCONJ
dpc-5329	192	20	tralokinumab	tralokinumab	NOUN
dpc-5329	192	21	,	,	PUNCT
dpc-5329	192	22	which	which	PRON
dpc-5329	192	23	targets	target	VERB
dpc-5329	192	24	il-13	il-13	X
dpc-5329	192	25	.	.	PUNCT
dpc-5329	193	1	oral	oral	PROPN
dpc-5329	193	2	janus	janus	PROPN
dpc-5329	193	3	kinase	kinase	PROPN
dpc-5329	193	4	(	(	PUNCT
dpc-5329	193	5	jak	jak	PROPN
dpc-5329	193	6	)	)	PUNCT
dpc-5329	193	7	inhibitors	inhibitor	NOUN
dpc-5329	193	8	have	have	AUX
dpc-5329	193	9	also	also	ADV
dpc-5329	193	10	recently	recently	ADV
dpc-5329	193	11	been	be	AUX
dpc-5329	193	12	approved	approve	VERB
dpc-5329	193	13	for	for	ADP
dpc-5329	193	14	treatment	treatment	NOUN
dpc-5329	193	15	of	of	ADP
dpc-5329	193	16	ad	ad	NOUN
dpc-5329	193	17	.	.	PUNCT
dpc-5329	194	1	although	although	SCONJ
dpc-5329	194	2	these	these	DET
dpc-5329	194	3	therapies	therapy	NOUN
dpc-5329	194	4	significantly	significantly	ADV
dpc-5329	194	5	improve	improve	VERB
dpc-5329	194	6	symptoms	symptom	NOUN
dpc-5329	194	7	,	,	PUNCT
dpc-5329	194	8	their	their	PRON
dpc-5329	194	9	variable	variable	ADJ
dpc-5329	194	10	response	response	NOUN
dpc-5329	194	11	rates	rate	NOUN
dpc-5329	194	12	and	and	CCONJ
dpc-5329	194	13	potential	potential	ADJ
dpc-5329	194	14	immune	immune	NOUN
dpc-5329	194	15	-	-	PUNCT
dpc-5329	194	16	related	relate	VERB
dpc-5329	194	17	risks	risk	NOUN
dpc-5329	194	18	,	,	PUNCT
dpc-5329	194	19	including	include	VERB
dpc-5329	194	20	susceptibility	susceptibility	NOUN
dpc-5329	194	21	to	to	ADP
dpc-5329	194	22	infections	infection	NOUN
dpc-5329	194	23	,	,	PUNCT
dpc-5329	194	24	present	present	ADJ
dpc-5329	194	25	challenges	challenge	NOUN
dpc-5329	194	26	for	for	ADP
dpc-5329	194	27	both	both	DET
dpc-5329	194	28	patients	patient	NOUN
dpc-5329	194	29	and	and	CCONJ
dpc-5329	194	30	clinicians	clinician	NOUN
dpc-5329	194	31	[	[	X
dpc-5329	194	32	39,40	39,40	NUM
dpc-5329	194	33	]	]	PUNCT
dpc-5329	194	34	.	.	PUNCT
dpc-5329	195	1	given	give	VERB
dpc-5329	195	2	the	the	DET
dpc-5329	195	3	multifactorial	multifactorial	ADJ
dpc-5329	195	4	nature	nature	NOUN
dpc-5329	195	5	of	of	ADP
dpc-5329	195	6	ad	ad	NOUN
dpc-5329	195	7	,	,	PUNCT
dpc-5329	195	8	a	a	DET
dpc-5329	195	9	more	more	ADV
dpc-5329	195	10	integrative	integrative	ADJ
dpc-5329	195	11	approach	approach	NOUN
dpc-5329	195	12	to	to	ADP
dpc-5329	195	13	treatment	treatment	NOUN
dpc-5329	195	14	should	should	AUX
dpc-5329	195	15	be	be	AUX
dpc-5329	195	16	explored	explore	VERB
dpc-5329	195	17	to	to	PART
dpc-5329	195	18	comprehensively	comprehensively	ADV
dpc-5329	195	19	address	address	VERB
dpc-5329	195	20	the	the	DET
dpc-5329	195	21	disease	disease	NOUN
dpc-5329	195	22	.	.	PUNCT
dpc-5329	196	1	emerging	emerge	VERB
dpc-5329	196	2	treatments	treatment	NOUN
dpc-5329	196	3	offer	offer	VERB
dpc-5329	196	4	promising	promise	VERB
dpc-5329	196	5	therapeutic	therapeutic	ADJ
dpc-5329	196	6	approaches	approach	NOUN
dpc-5329	196	7	by	by	ADP
dpc-5329	196	8	leveraging	leverage	VERB
dpc-5329	196	9	the	the	DET
dpc-5329	196	10	interconnected	interconnected	ADJ
dpc-5329	196	11	singe	singe	NOUN
dpc-5329	196	12	network	network	NOUN
dpc-5329	196	13	components	component	NOUN
dpc-5329	196	14	.	.	PUNCT
dpc-5329	197	1	for	for	ADP
dpc-5329	197	2	instance	instance	NOUN
dpc-5329	197	3	,	,	PUNCT
dpc-5329	197	4	research	research	NOUN
dpc-5329	197	5	on	on	ADP
dpc-5329	197	6	gut	gut	NOUN
dpc-5329	197	7	microbiome	microbiome	ADJ
dpc-5329	197	8	modulation	modulation	NOUN
dpc-5329	197	9	with	with	ADP
dpc-5329	197	10	probiotics	probiotic	NOUN
dpc-5329	197	11	,	,	PUNCT
dpc-5329	197	12	postbiotics	postbiotic	NOUN
dpc-5329	197	13	,	,	PUNCT
dpc-5329	197	14	and	and	CCONJ
dpc-5329	197	15	dietary	dietary	ADJ
dpc-5329	197	16	interventions	intervention	NOUN
dpc-5329	197	17	has	have	AUX
dpc-5329	197	18	suggested	suggest	VERB
dpc-5329	197	19	potential	potential	NOUN
dpc-5329	197	20	in	in	ADP
dpc-5329	197	21	such	such	ADJ
dpc-5329	197	22	agents	agent	NOUN
dpc-5329	197	23	at	at	ADP
dpc-5329	197	24	restoring	restore	VERB
dpc-5329	197	25	immune	immune	ADJ
dpc-5329	197	26	balance	balance	NOUN
dpc-5329	197	27	and	and	CCONJ
dpc-5329	197	28	enhancing	enhance	VERB
dpc-5329	197	29	barrier	barrier	NOUN
dpc-5329	197	30	integrity	integrity	NOUN
dpc-5329	197	31	in	in	ADP
dpc-5329	197	32	ad	ad	NOUN
dpc-5329	197	33	[	[	X
dpc-5329	197	34	28,40	28,40	X
dpc-5329	197	35	]	]	X
dpc-5329	197	36	.	.	PUNCT
dpc-5329	198	1	additionally	additionally	ADV
dpc-5329	198	2	,	,	PUNCT
dpc-5329	198	3	agents	agent	NOUN
dpc-5329	198	4	review	review	VERB
dpc-5329	198	5	|	|	ADV
dpc-5329	198	6	dermatol	dermatol	ADJ
dpc-5329	198	7	pract	pract	NOUN
dpc-5329	198	8	concept	concept	NOUN
dpc-5329	198	9	.	.	PUNCT
dpc-5329	199	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	199	2	7	7	NUM
dpc-5329	199	3	26	26	NUM
dpc-5329	199	4	.	.	PUNCT
dpc-5329	200	1	yosipovitch	yosipovitch	PROPN
dpc-5329	200	2	g	g	PROPN
dpc-5329	200	3	,	,	PUNCT
dpc-5329	200	4	berger	berger	PROPN
dpc-5329	200	5	t	t	PROPN
dpc-5329	200	6	,	,	PUNCT
dpc-5329	200	7	fassett	fassett	PROPN
dpc-5329	200	8	ms	ms	PROPN
dpc-5329	200	9	.	.	PROPN
dpc-5329	200	10	neuroimmune	neuroimmune	PROPN
dpc-5329	200	11	interactions	interaction	NOUN
dpc-5329	200	12	in	in	ADP
dpc-5329	200	13	chronic	chronic	ADJ
dpc-5329	200	14	itch	itch	NOUN
dpc-5329	200	15	of	of	ADP
dpc-5329	200	16	atopic	atopic	NOUN
dpc-5329	200	17	dermatitis	dermatitis	NOUN
dpc-5329	200	18	.	.	PUNCT
dpc-5329	201	1	journal	journal	PROPN
dpc-5329	201	2	of	of	ADP
dpc-5329	201	3	the	the	DET
dpc-5329	201	4	european	european	PROPN
dpc-5329	201	5	academy	academy	PROPN
dpc-5329	201	6	of	of	ADP
dpc-5329	201	7	dermatology	dermatology	NOUN
dpc-5329	201	8	and	and	CCONJ
dpc-5329	201	9	venereology	venereology	NOUN
dpc-5329	201	10	.	.	PUNCT
dpc-5329	202	1	2019;34(2):239	2019;34(2):239	NUM
dpc-5329	202	2	.	.	PUNCT
dpc-5329	203	1	doi:10.1111	doi:10.1111	PROPN
dpc-5329	203	2	/	/	SYM
dpc-5329	203	3	jdv.15973	jdv.15973	PROPN
dpc-5329	203	4	.	.	PUNCT
dpc-5329	204	1	pmid	pmid	NOUN
dpc-5329	204	2	:	:	PUNCT
dpc-5329	204	3	31566796	31566796	NUM
dpc-5329	204	4	27	27	NUM
dpc-5329	204	5	.	.	PUNCT
dpc-5329	205	1	symons	symons	PROPN
dpc-5329	205	2	fj	fj	PROPN
dpc-5329	205	3	,	,	PUNCT
dpc-5329	205	4	wendelschafer	wendelschafer	PROPN
dpc-5329	205	5	-	-	PUNCT
dpc-5329	205	6	crabb	crabb	NOUN
dpc-5329	205	7	g	g	PROPN
dpc-5329	205	8	,	,	PUNCT
dpc-5329	205	9	kennedy	kennedy	PROPN
dpc-5329	205	10	w	w	PROPN
dpc-5329	205	11	,	,	PUNCT
dpc-5329	205	12	hardrict	hardrict	PROPN
dpc-5329	205	13	r	r	NOUN
dpc-5329	205	14	,	,	PUNCT
dpc-5329	205	15	dahl	dahl	PROPN
dpc-5329	205	16	n	n	CCONJ
dpc-5329	205	17	,	,	PUNCT
dpc-5329	205	18	bodfish	bodfish	PROPN
dpc-5329	205	19	jw	jw	PROPN
dpc-5329	205	20	.	.	PROPN
dpc-5329	205	21	evidence	evidence	NOUN
dpc-5329	205	22	of	of	ADP
dpc-5329	205	23	altered	altered	ADJ
dpc-5329	205	24	epidermal	epidermal	ADJ
dpc-5329	205	25	nerve	nerve	NOUN
dpc-5329	205	26	fiber	fiber	NOUN
dpc-5329	205	27	morphology	morphology	NOUN
dpc-5329	205	28	in	in	ADP
dpc-5329	205	29	adults	adult	NOUN
dpc-5329	205	30	with	with	ADP
dpc-5329	205	31	self	self	NOUN
dpc-5329	205	32	-	-	PUNCT
dpc-5329	205	33	injurious	injurious	ADJ
dpc-5329	205	34	behavior	behavior	NOUN
dpc-5329	205	35	and	and	CCONJ
dpc-5329	205	36	neurodevelopmental	neurodevelopmental	ADJ
dpc-5329	205	37	disorders	disorder	NOUN
dpc-5329	205	38	.	.	PUNCT
dpc-5329	206	1	pain	pain	NOUN
dpc-5329	206	2	.	.	PUNCT
dpc-5329	207	1	2007;134(1	2007;134(1	X
dpc-5329	207	2	-	-	SYM
dpc-5329	207	3	2):232	2):232	NUM
dpc-5329	207	4	.	.	PUNCT
dpc-5329	207	5	doi:10.1016	doi:10.1016	PROPN
dpc-5329	207	6	/	/	SYM
dpc-5329	207	7	j.pain.2007.07.022	j.pain.2007.07.022	PROPN
dpc-5329	207	8	.	.	PUNCT
dpc-5329	208	1	pmid	pmid	PROPN
dpc-5329	208	2	:	:	PUNCT
dpc-5329	208	3	17850969	17850969	NUM
dpc-5329	208	4	28	28	NUM
dpc-5329	208	5	.	.	PUNCT
dpc-5329	209	1	tominaga	tominaga	NOUN
dpc-5329	209	2	m	m	PROPN
dpc-5329	209	3	,	,	PUNCT
dpc-5329	209	4	takamori	takamori	NOUN
dpc-5329	209	5	k.	k.	PROPN
dpc-5329	209	6	peripheral	peripheral	ADJ
dpc-5329	209	7	itch	itch	NOUN
dpc-5329	209	8	sensitization	sensitization	NOUN
dpc-5329	209	9	in	in	ADP
dpc-5329	209	10	atopic	atopic	NOUN
dpc-5329	209	11	dermatitis	dermatitis	NOUN
dpc-5329	209	12	.	.	PUNCT
dpc-5329	210	1	allergology	allergology	PROPN
dpc-5329	210	2	international	international	PROPN
dpc-5329	210	3	.	.	PUNCT
dpc-5329	211	1	2022;71(3):265	2022;71(3):265	NUM
dpc-5329	211	2	-	-	SYM
dpc-5329	211	3	277	277	NUM
dpc-5329	211	4	.	.	PUNCT
dpc-5329	212	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	212	2	/	/	SYM
dpc-5329	212	3	j.alit.2022.04.003	j.alit.2022.04.003	PROPN
dpc-5329	212	4	29	29	NUM
dpc-5329	212	5	.	.	PUNCT
dpc-5329	213	1	gaspar	gaspar	PROPN
dpc-5329	213	2	nk	nk	PROPN
dpc-5329	213	3	,	,	PUNCT
dpc-5329	213	4	aidé	aidé	PROPN
dpc-5329	213	5	mk	mk	PROPN
dpc-5329	213	6	.	.	PUNCT
dpc-5329	214	1	atopic	atopic	PROPN
dpc-5329	214	2	dermatitis	dermatitis	PROPN
dpc-5329	214	3	:	:	PUNCT
dpc-5329	214	4	allergic	allergic	ADJ
dpc-5329	214	5	dermatitis	dermatitis	NOUN
dpc-5329	214	6	or	or	CCONJ
dpc-5329	214	7	neuroimmune	neuroimmune	NOUN
dpc-5329	214	8	dermatitis	dermatitis	NOUN
dpc-5329	214	9	?	?	PUNCT
dpc-5329	215	1	anais	anais	PROPN
dpc-5329	215	2	brasileiros	brasileiros	PROPN
dpc-5329	215	3	de	de	PROPN
dpc-5329	215	4	dermatologia	dermatologia	PROPN
dpc-5329	215	5	.	.	PUNCT
dpc-5329	216	1	2016;91(4):479	2016;91(4):479	NUM
dpc-5329	216	2	.	.	PUNCT
dpc-5329	217	1	doi:10.1590	doi:10.1590	ADJ
dpc-5329	217	2	/	/	SYM
dpc-5329	217	3	abd1806	abd1806	PROPN
dpc-5329	217	4	-	-	PUNCT
dpc-5329	217	5	4841.20164211	4841.20164211	PROPN
dpc-5329	217	6	.	.	PUNCT
dpc-5329	218	1	pmid	pmid	NOUN
dpc-5329	218	2	:	:	PUNCT
dpc-5329	218	3	27579744	27579744	NUM
dpc-5329	218	4	30	30	NUM
dpc-5329	218	5	.	.	PUNCT
dpc-5329	219	1	sadowsky	sadowsky	PROPN
dpc-5329	219	2	rl	rl	PROPN
dpc-5329	219	3	,	,	PUNCT
dpc-5329	219	4	sulejmani	sulejmani	X
dpc-5329	219	5	p	p	X
dpc-5329	219	6	,	,	PUNCT
dpc-5329	219	7	lio	lio	PROPN
dpc-5329	219	8	pa	pa	PROPN
dpc-5329	219	9	.	.	PROPN
dpc-5329	219	10	atopic	atopic	PROPN
dpc-5329	219	11	dermatitis	dermatitis	PROPN
dpc-5329	219	12	:	:	PUNCT
dpc-5329	219	13	beyond	beyond	ADP
dpc-5329	219	14	the	the	DET
dpc-5329	219	15	skin	skin	NOUN
dpc-5329	219	16	and	and	CCONJ
dpc-5329	219	17	into	into	ADP
dpc-5329	219	18	the	the	DET
dpc-5329	219	19	gut	gut	NOUN
dpc-5329	219	20	.	.	PUNCT
dpc-5329	220	1	j	j	PROPN
dpc-5329	220	2	clin	clin	PROPN
dpc-5329	220	3	med	med	PROPN
dpc-5329	220	4	.	.	PUNCT
dpc-5329	221	1	2023;12(17):5534	2023;12(17):5534	X
dpc-5329	221	2	.	.	PUNCT
dpc-5329	221	3	doi:10.3390	doi:10.3390	NOUN
dpc-5329	221	4	/	/	SYM
dpc-5329	221	5	jcm12175534	jcm12175534	NOUN
dpc-5329	221	6	.	.	PUNCT
dpc-5329	222	1	pmid	pmid	NOUN
dpc-5329	222	2	:	:	PUNCT
dpc-5329	222	3	37685600	37685600	NUM
dpc-5329	222	4	31	31	NUM
dpc-5329	222	5	.	.	PUNCT
dpc-5329	223	1	paz	paz	PROPN
dpc-5329	223	2	m	m	PROPN
dpc-5329	223	3	,	,	PUNCT
dpc-5329	223	4	lio	lio	PROPN
dpc-5329	223	5	p.	p.	NOUN
dpc-5329	223	6	postbiotics	postbiotic	NOUN
dpc-5329	223	7	and	and	CCONJ
dpc-5329	223	8	atopic	atopic	NOUN
dpc-5329	223	9	dermatitis	dermatitis	NOUN
dpc-5329	223	10	:	:	PUNCT
dpc-5329	223	11	aiming	aim	VERB
dpc-5329	223	12	to	to	PART
dpc-5329	223	13	modulate	modulate	VERB
dpc-5329	223	14	the	the	DET
dpc-5329	223	15	gut	gut	NOUN
dpc-5329	223	16	-	-	PUNCT
dpc-5329	223	17	skin	skin	NOUN
dpc-5329	223	18	axis	axis	NOUN
dpc-5329	223	19	.	.	PUNCT
dpc-5329	224	1	journal	journal	NOUN
dpc-5329	224	2	of	of	ADP
dpc-5329	224	3	integrative	integrative	ADJ
dpc-5329	224	4	dermatology	dermatology	NOUN
dpc-5329	224	5	.	.	PUNCT
dpc-5329	225	1	published	publish	VERB
dpc-5329	225	2	online	online	ADJ
dpc-5329	225	3	june	june	PROPN
dpc-5329	225	4	25	25	NUM
dpc-5329	225	5	,	,	PUNCT
dpc-5329	225	6	2024	2024	NUM
dpc-5329	225	7	.	.	PUNCT
dpc-5329	226	1	accessed	access	VERB
dpc-5329	226	2	august	august	PROPN
dpc-5329	226	3	18	18	NUM
dpc-5329	226	4	,	,	PUNCT
dpc-5329	226	5	2024	2024	NUM
dpc-5329	226	6	.	.	PUNCT
dpc-5329	227	1	https://www.jintegrativederm.org/article/120208-postbiotics-and-atopic-dermatitis-aiming-to-modulate-the-gut-skin-axis	https://www.jintegrativederm.org/article/120208-postbiotics-and-atopic-dermatitis-aiming-to-modulate-the-gut-skin-axis	PROPN
dpc-5329	227	2	32	32	NUM
dpc-5329	227	3	.	.	PUNCT
dpc-5329	228	1	markowiak	markowiak	PROPN
dpc-5329	228	2	-	-	PUNCT
dpc-5329	228	3	kopeć	kopeć	PROPN
dpc-5329	228	4	p	p	NOUN
dpc-5329	228	5	,	,	PUNCT
dpc-5329	228	6	śliżewska	śliżewska	ADJ
dpc-5329	228	7	k.	k.	PUNCT
dpc-5329	229	1	the	the	DET
dpc-5329	229	2	effect	effect	NOUN
dpc-5329	229	3	of	of	ADP
dpc-5329	229	4	probiotics	probiotic	NOUN
dpc-5329	229	5	on	on	ADP
dpc-5329	229	6	the	the	DET
dpc-5329	229	7	production	production	NOUN
dpc-5329	229	8	of	of	ADP
dpc-5329	229	9	short	short	ADJ
dpc-5329	229	10	-	-	PUNCT
dpc-5329	229	11	chain	chain	NOUN
dpc-5329	229	12	fatty	fatty	NOUN
dpc-5329	229	13	acids	acid	NOUN
dpc-5329	229	14	by	by	ADP
dpc-5329	229	15	human	human	ADJ
dpc-5329	229	16	intestinal	intestinal	ADJ
dpc-5329	229	17	microbiome	microbiome	NOUN
dpc-5329	229	18	.	.	PUNCT
dpc-5329	230	1	nutrients	nutrient	NOUN
dpc-5329	230	2	.	.	PUNCT
dpc-5329	231	1	2020;12(4):1107	2020;12(4):1107	NUM
dpc-5329	231	2	.	.	PUNCT
dpc-5329	232	1	doi:10.3390	doi:10.3390	NOUN
dpc-5329	232	2	/nu12041107	/nu12041107	PUNCT
dpc-5329	232	3	.	.	PUNCT
dpc-5329	233	1	pmid	pmid	NOUN
dpc-5329	233	2	:	:	PUNCT
dpc-5329	233	3	32316181	32316181	NUM
dpc-5329	233	4	33	33	NUM
dpc-5329	233	5	.	.	PUNCT
dpc-5329	234	1	mousa	mousa	PROPN
dpc-5329	234	2	wk	wk	PROPN
dpc-5329	234	3	,	,	PUNCT
dpc-5329	234	4	chehadeh	chehadeh	PROPN
dpc-5329	234	5	f	f	PROPN
dpc-5329	234	6	,	,	PUNCT
dpc-5329	234	7	husband	husband	NOUN
dpc-5329	234	8	s.	s.	PROPN
dpc-5329	234	9	microbial	microbial	ADJ
dpc-5329	234	10	dysbiosis	dysbiosis	NOUN
dpc-5329	234	11	in	in	ADP
dpc-5329	234	12	the	the	DET
dpc-5329	234	13	gut	gut	NOUN
dpc-5329	234	14	drives	drive	VERB
dpc-5329	234	15	systemic	systemic	ADJ
dpc-5329	234	16	autoimmune	autoimmune	ADJ
dpc-5329	234	17	diseases	disease	NOUN
dpc-5329	234	18	.	.	PUNCT
dpc-5329	235	1	front	front	ADJ
dpc-5329	235	2	immunol	immunol	NOUN
dpc-5329	235	3	.	.	PUNCT
dpc-5329	236	1	2022;13:906258	2022;13:906258	X
dpc-5329	236	2	.	.	PUNCT
dpc-5329	236	3	doi:10.3389	doi:10.3389	PROPN
dpc-5329	236	4	/	/	SYM
dpc-5329	236	5	fimmu.2022.906258	fimmu.2022.906258	PROPN
dpc-5329	236	6	.	.	PUNCT
dpc-5329	237	1	pmid	pmid	NOUN
dpc-5329	237	2	:	:	PUNCT
dpc-5329	237	3	36341463	36341463	NUM
dpc-5329	237	4	34	34	NUM
dpc-5329	237	5	.	.	PUNCT
dpc-5329	238	1	terao	terao	PROPN
dpc-5329	238	2	m	m	PROPN
dpc-5329	238	3	,	,	PUNCT
dpc-5329	238	4	katayama	katayama	PROPN
dpc-5329	238	5	i.	i.	PROPN
dpc-5329	238	6	local	local	PROPN
dpc-5329	238	7	cortisol	cortisol	PROPN
dpc-5329	238	8	/	/	SYM
dpc-5329	238	9	corticosterone	corticosterone	NOUN
dpc-5329	238	10	activation	activation	NOUN
dpc-5329	238	11	in	in	ADP
dpc-5329	238	12	skin	skin	NOUN
dpc-5329	238	13	physiology	physiology	NOUN
dpc-5329	238	14	and	and	CCONJ
dpc-5329	238	15	pathology	pathology	NOUN
dpc-5329	238	16	.	.	PUNCT
dpc-5329	239	1	journal	journal	PROPN
dpc-5329	239	2	of	of	ADP
dpc-5329	239	3	dermatological	dermatological	ADJ
dpc-5329	239	4	science	science	NOUN
dpc-5329	239	5	.	.	PUNCT
dpc-5329	240	1	2016;84(1):11	2016;84(1):11	NUM
dpc-5329	240	2	-	-	SYM
dpc-5329	240	3	16	16	NUM
dpc-5329	240	4	.	.	PUNCT
dpc-5329	241	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	241	2	/	/	SYM
dpc-5329	242	1	j.jdermsci	j.jdermsci	PROPN
dpc-5329	242	2	.2016.06.014	.2016.06.014	PROPN
dpc-5329	242	3	35	35	NUM
dpc-5329	242	4	.	.	PUNCT
dpc-5329	243	1	chen	chen	PROPN
dpc-5329	243	2	y	y	PROPN
dpc-5329	243	3	,	,	PUNCT
dpc-5329	243	4	lyga	lyga	PROPN
dpc-5329	243	5	j.	j.	PROPN
dpc-5329	243	6	brain	brain	PROPN
dpc-5329	243	7	-	-	PUNCT
dpc-5329	243	8	skin	skin	NOUN
dpc-5329	243	9	connection	connection	NOUN
dpc-5329	243	10	:	:	PUNCT
dpc-5329	243	11	stress	stress	NOUN
dpc-5329	243	12	,	,	PUNCT
dpc-5329	243	13	inflammation	inflammation	NOUN
dpc-5329	243	14	and	and	CCONJ
dpc-5329	243	15	skin	skin	NOUN
dpc-5329	243	16	aging	aging	NOUN
dpc-5329	243	17	.	.	PUNCT
dpc-5329	244	1	inflammation	inflammation	NOUN
dpc-5329	244	2	&	&	CCONJ
dpc-5329	244	3	allergy	allergy	PROPN
dpc-5329	244	4	drug	drug	NOUN
dpc-5329	244	5	targets	target	NOUN
dpc-5329	244	6	.	.	PUNCT
dpc-5329	245	1	2014;13(3):177	2014;13(3):177	PROPN
dpc-5329	245	2	.	.	PUNCT
dpc-5329	246	1	doi:10.2174/1871528113666140522104422	doi:10.2174/1871528113666140522104422	NOUN
dpc-5329	246	2	.	.	PUNCT
dpc-5329	247	1	pmid	pmid	NOUN
dpc-5329	247	2	:	:	PUNCT
dpc-5329	247	3	24853682	24853682	NUM
dpc-5329	247	4	36	36	NUM
dpc-5329	247	5	.	.	PUNCT
dpc-5329	248	1	lin	lin	PROPN
dpc-5329	248	2	tk	tk	PROPN
dpc-5329	248	3	,	,	PUNCT
dpc-5329	248	4	zhong	zhong	PROPN
dpc-5329	248	5	l	l	PROPN
dpc-5329	248	6	,	,	PUNCT
dpc-5329	248	7	santiago	santiago	PROPN
dpc-5329	248	8	jl	jl	PROPN
dpc-5329	248	9	.	.	PROPN
dpc-5329	248	10	association	association	PROPN
dpc-5329	248	11	between	between	ADP
dpc-5329	248	12	stress	stress	NOUN
dpc-5329	248	13	and	and	CCONJ
dpc-5329	248	14	the	the	DET
dpc-5329	248	15	hpa	hpa	NOUN
dpc-5329	248	16	axis	axis	NOUN
dpc-5329	248	17	in	in	ADP
dpc-5329	248	18	the	the	DET
dpc-5329	248	19	atopic	atopic	NOUN
dpc-5329	248	20	dermatitis	dermatitis	NOUN
dpc-5329	248	21	.	.	PUNCT
dpc-5329	249	1	international	international	ADJ
dpc-5329	249	2	journal	journal	NOUN
dpc-5329	249	3	of	of	ADP
dpc-5329	249	4	molecular	molecular	ADJ
dpc-5329	249	5	sciences	science	NOUN
dpc-5329	249	6	.	.	PUNCT
dpc-5329	250	1	2017;18(10):2131	2017;18(10):2131	NUM
dpc-5329	250	2	.	.	PUNCT
dpc-5329	250	3	doi:10.3390	doi:10.3390	NOUN
dpc-5329	250	4	/ijms18102131	/ijms18102131	PUNCT
dpc-5329	250	5	.	.	PUNCT
dpc-5329	251	1	pmid	pmid	NOUN
dpc-5329	251	2	:	:	PUNCT
dpc-5329	251	3	29023418	29023418	NUM
dpc-5329	251	4	37	37	NUM
dpc-5329	251	5	.	.	PUNCT
dpc-5329	252	1	suárez	suárez	PROPN
dpc-5329	252	2	al	al	PROPN
dpc-5329	252	3	,	,	PUNCT
dpc-5329	252	4	feramisco	feramisco	PROPN
dpc-5329	252	5	jd	jd	PROPN
dpc-5329	252	6	,	,	PUNCT
dpc-5329	252	7	koo	koo	PROPN
dpc-5329	252	8	j	j	PROPN
dpc-5329	252	9	,	,	PUNCT
dpc-5329	252	10	steinhoff	steinhoff	ADJ
dpc-5329	252	11	m.	m.	NOUN
dpc-5329	252	12	psychoneuroimmunology	psychoneuroimmunology	NOUN
dpc-5329	252	13	of	of	ADP
dpc-5329	252	14	psychological	psychological	ADJ
dpc-5329	252	15	stress	stress	NOUN
dpc-5329	252	16	and	and	CCONJ
dpc-5329	252	17	atopic	atopic	NOUN
dpc-5329	252	18	dermatitis	dermatitis	NOUN
dpc-5329	252	19	:	:	PUNCT
dpc-5329	252	20	pathophysiologic	pathophysiologic	ADJ
dpc-5329	252	21	and	and	CCONJ
dpc-5329	252	22	therapeutic	therapeutic	ADJ
dpc-5329	252	23	updates	update	NOUN
dpc-5329	252	24	.	.	PUNCT
dpc-5329	253	1	acta	acta	PROPN
dpc-5329	253	2	dermato	dermato	PROPN
dpc-5329	253	3	-	-	PUNCT
dpc-5329	253	4	venereologica	venereologica	PROPN
dpc-5329	253	5	.	.	PUNCT
dpc-5329	254	1	2012;92(1):7	2012;92(1):7	NOUN
dpc-5329	254	2	.	.	PUNCT
dpc-5329	255	1	doi:10.2340/00015555	doi:10.2340/00015555	NOUN
dpc-5329	255	2	-	-	PUNCT
dpc-5329	255	3	1188	1188	NUM
dpc-5329	255	4	.	.	PUNCT
dpc-5329	256	1	pmid	pmid	NOUN
dpc-5329	256	2	:	:	PUNCT
dpc-5329	256	3	22101513	22101513	NUM
dpc-5329	256	4	38	38	NUM
dpc-5329	256	5	.	.	PUNCT
dpc-5329	257	1	begolka	begolka	PROPN
dpc-5329	257	2	ws	ws	PROPN
dpc-5329	257	3	,	,	PUNCT
dpc-5329	257	4	chovatiya	chovatiya	PROPN
dpc-5329	257	5	r	r	PROPN
dpc-5329	257	6	,	,	PUNCT
dpc-5329	257	7	thibau	thibau	NOUN
dpc-5329	257	8	ij	ij	NOUN
dpc-5329	257	9	,	,	PUNCT
dpc-5329	257	10	silverberg	silverberg	PROPN
dpc-5329	257	11	ji	ji	PROPN
dpc-5329	257	12	.	.	PROPN
dpc-5329	257	13	financial	financial	ADJ
dpc-5329	257	14	burden	burden	NOUN
dpc-5329	257	15	of	of	ADP
dpc-5329	257	16	atopic	atopic	NOUN
dpc-5329	257	17	dermatitis	dermatitis	NOUN
dpc-5329	257	18	out	out	ADP
dpc-5329	257	19	-	-	PUNCT
dpc-5329	257	20	of	of	ADP
dpc-5329	257	21	-	-	PUNCT
dpc-5329	257	22	pocket	pocket	NOUN
dpc-5329	257	23	health	health	NOUN
dpc-5329	257	24	care	care	NOUN
dpc-5329	257	25	expenses	expense	NOUN
dpc-5329	257	26	in	in	ADP
dpc-5329	257	27	the	the	DET
dpc-5329	257	28	united	united	PROPN
dpc-5329	257	29	states	states	PROPN
dpc-5329	257	30	.	.	PUNCT
dpc-5329	258	1	dermatitis	dermatitis	NOUN
dpc-5329	258	2	.	.	PUNCT
dpc-5329	259	1	2020;32(1	2020;32(1	NUM
dpc-5329	259	2	suppl):s62	suppl):s62	PROPN
dpc-5329	259	3	.	.	PROPN
dpc-5329	259	4	doi:10.1097	doi:10.1097	PROPN
dpc-5329	259	5	/	/	SYM
dpc-5329	259	6	der.0000000000000715	der.0000000000000715	NOUN
dpc-5329	259	7	.	.	PUNCT
dpc-5329	260	1	pmid	pmid	NOUN
dpc-5329	260	2	:	:	PUNCT
dpc-5329	260	3	33323748	33323748	NUM
dpc-5329	260	4	39	39	NUM
dpc-5329	260	5	.	.	PUNCT
dpc-5329	261	1	courtney	courtney	PROPN
dpc-5329	261	2	a	a	PRON
dpc-5329	261	3	,	,	PUNCT
dpc-5329	261	4	su	su	PROPN
dpc-5329	261	5	jc	jc	PROPN
dpc-5329	261	6	.	.	PUNCT
dpc-5329	262	1	the	the	DET
dpc-5329	262	2	psychology	psychology	NOUN
dpc-5329	262	3	of	of	ADP
dpc-5329	262	4	atopic	atopic	NOUN
dpc-5329	262	5	dermatitis	dermatitis	NOUN
dpc-5329	262	6	.	.	PUNCT
dpc-5329	263	1	journal	journal	PROPN
dpc-5329	263	2	of	of	ADP
dpc-5329	263	3	clinical	clinical	ADJ
dpc-5329	263	4	medicine	medicine	NOUN
dpc-5329	263	5	.	.	PUNCT
dpc-5329	264	1	2024;13(6):1602	2024;13(6):1602	NUM
dpc-5329	264	2	.	.	PUNCT
dpc-5329	265	1	doi:10.3390	doi:10.3390	NOUN
dpc-5329	265	2	/jcm13061602	/jcm13061602	PUNCT
dpc-5329	266	1	40	40	NUM
dpc-5329	266	2	.	.	PUNCT
dpc-5329	267	1	kim	kim	PROPN
dpc-5329	267	2	bj	bj	PROPN
dpc-5329	267	3	,	,	PUNCT
dpc-5329	267	4	lee	lee	PROPN
dpc-5329	267	5	nr	nr	PROPN
dpc-5329	267	6	,	,	PUNCT
dpc-5329	267	7	lee	lee	PROPN
dpc-5329	267	8	ch	ch	PROPN
dpc-5329	267	9	,	,	PUNCT
dpc-5329	267	10	et	et	PROPN
dpc-5329	267	11	al	al	PROPN
dpc-5329	267	12	.	.	PROPN
dpc-5329	267	13	increased	increase	VERB
dpc-5329	267	14	expression	expression	NOUN
dpc-5329	267	15	of	of	ADP
dpc-5329	267	16	11β	11β	PROPN
dpc-5329	267	17	-	-	PUNCT
dpc-5329	267	18	hydroxysteroid	hydroxysteroid	ADJ
dpc-5329	267	19	dehydrogenase	dehydrogenase	NOUN
dpc-5329	267	20	type	type	NOUN
dpc-5329	267	21	1	1	NUM
dpc-5329	267	22	contributes	contribute	VERB
dpc-5329	267	23	to	to	ADP
dpc-5329	267	24	epidermal	epidermal	ADJ
dpc-5329	267	25	permeability	permeability	NOUN
dpc-5329	267	26	barrier	barrier	NOUN
dpc-5329	267	27	dysfunction	dysfunction	NOUN
dpc-5329	267	28	in	in	ADP
dpc-5329	267	29	aged	aged	ADJ
dpc-5329	267	30	skin	skin	NOUN
dpc-5329	267	31	.	.	PUNCT
dpc-5329	268	1	international	international	ADJ
dpc-5329	268	2	therapies	therapy	NOUN
dpc-5329	268	3	.	.	PUNCT
dpc-5329	269	1	j	j	PROPN
dpc-5329	269	2	allergy	allergy	PROPN
dpc-5329	269	3	clin	clin	PROPN
dpc-5329	269	4	immunol	immunol	PROPN
dpc-5329	269	5	.	.	PUNCT
dpc-5329	269	6	2017;139(4	2017;139(4	NUM
dpc-5329	270	1	suppl):s65	suppl):s65	ADJ
dpc-5329	270	2	-	-	NOUN
dpc-5329	270	3	s76	s76	NOUN
dpc-5329	270	4	.	.	PUNCT
dpc-5329	271	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	271	2	/	/	SYM
dpc-5329	271	3	j.jaci.2017.01.011	j.jaci.2017.01.011	PROPN
dpc-5329	271	4	.	.	PUNCT
dpc-5329	272	1	pmid	pmid	NOUN
dpc-5329	272	2	:	:	PUNCT
dpc-5329	272	3	28390479	28390479	NUM
dpc-5329	272	4	11	11	NUM
dpc-5329	272	5	.	.	PUNCT
dpc-5329	273	1	sims	sims	PROPN
dpc-5329	273	2	jt	jt	PROPN
dpc-5329	273	3	,	,	PUNCT
dpc-5329	273	4	chang	chang	PROPN
dpc-5329	273	5	cy	cy	PROPN
dpc-5329	273	6	,	,	PUNCT
dpc-5329	273	7	higgs	higgs	PROPN
dpc-5329	273	8	re	re	PROPN
dpc-5329	273	9	,	,	PUNCT
dpc-5329	273	10	et	et	PROPN
dpc-5329	273	11	al	al	PROPN
dpc-5329	273	12	.	.	PUNCT
dpc-5329	273	13	insights	insight	NOUN
dpc-5329	273	14	into	into	ADP
dpc-5329	273	15	adult	adult	NOUN
dpc-5329	273	16	atopic	atopic	NOUN
dpc-5329	273	17	dermatitis	dermatitis	NOUN
dpc-5329	273	18	heterogeneity	heterogeneity	NOUN
dpc-5329	273	19	derived	derive	VERB
dpc-5329	273	20	from	from	ADP
dpc-5329	273	21	circulating	circulate	VERB
dpc-5329	273	22	biomarker	biomarker	NOUN
dpc-5329	273	23	profiling	profiling	NOUN
dpc-5329	273	24	in	in	ADP
dpc-5329	273	25	patients	patient	NOUN
dpc-5329	273	26	with	with	ADP
dpc-5329	273	27	moderate	moderate	ADJ
dpc-5329	273	28	-	-	PUNCT
dpc-5329	273	29	to	to	ADP
dpc-5329	273	30	-	-	PUNCT
dpc-5329	273	31	severe	severe	ADJ
dpc-5329	273	32	disease	disease	NOUN
dpc-5329	273	33	.	.	PUNCT
dpc-5329	274	1	experimental	experimental	ADJ
dpc-5329	274	2	dermatology	dermatology	NOUN
dpc-5329	274	3	.	.	PUNCT
dpc-5329	275	1	2021;30(11):1650	2021;30(11):1650	NUM
dpc-5329	275	2	-	-	SYM
dpc-5329	275	3	1661	1661	NUM
dpc-5329	275	4	.	.	PUNCT
dpc-5329	276	1	doi:10.1111	doi:10.1111	ADJ
dpc-5329	276	2	/exd.14389	/exd.14389	PROPN
dpc-5329	277	1	12	12	NUM
dpc-5329	277	2	.	.	PUNCT
dpc-5329	278	1	czarnowicki	czarnowicki	PROPN
dpc-5329	278	2	t	t	PROPN
dpc-5329	278	3	,	,	PUNCT
dpc-5329	278	4	he	he	PRON
dpc-5329	278	5	h	h	VERB
dpc-5329	278	6	,	,	PUNCT
dpc-5329	278	7	krueger	krueger	PROPN
dpc-5329	278	8	jg	jg	PROPN
dpc-5329	278	9	,	,	PUNCT
dpc-5329	278	10	guttman	guttman	ADJ
dpc-5329	278	11	-	-	PUNCT
dpc-5329	278	12	yassky	yassky	ADJ
dpc-5329	278	13	e.	e.	PROPN
dpc-5329	278	14	atopic	atopic	PROPN
dpc-5329	278	15	dermatitis	dermatitis	PROPN
dpc-5329	278	16	endotypes	endotype	NOUN
dpc-5329	278	17	and	and	CCONJ
dpc-5329	278	18	implications	implication	NOUN
dpc-5329	278	19	for	for	ADP
dpc-5329	278	20	targeted	targeted	ADJ
dpc-5329	278	21	therapeutics	therapeutic	NOUN
dpc-5329	278	22	.	.	PUNCT
dpc-5329	279	1	journal	journal	PROPN
dpc-5329	279	2	of	of	ADP
dpc-5329	279	3	allergy	allergy	NOUN
dpc-5329	279	4	and	and	CCONJ
dpc-5329	279	5	clinical	clinical	ADJ
dpc-5329	279	6	immunology	immunology	NOUN
dpc-5329	279	7	.	.	PUNCT
dpc-5329	280	1	2019;143(1):1	2019;143(1):1	NUM
dpc-5329	280	2	-	-	SYM
dpc-5329	280	3	11	11	NUM
dpc-5329	280	4	.	.	PUNCT
dpc-5329	281	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	281	2	/	/	SYM
dpc-5329	281	3	j.jaci.2018.10.032	j.jaci.2018.10.032	PROPN
dpc-5329	281	4	.	.	PUNCT
dpc-5329	282	1	pmid	pmid	NOUN
dpc-5329	282	2	:	:	PUNCT
dpc-5329	282	3	30612663	30612663	NUM
dpc-5329	282	4	13	13	NUM
dpc-5329	282	5	.	.	PUNCT
dpc-5329	283	1	hawerkamp	hawerkamp	PROPN
dpc-5329	283	2	hc	hc	PROPN
dpc-5329	283	3	,	,	PUNCT
dpc-5329	283	4	fahy	fahy	PROPN
dpc-5329	283	5	cmr	cmr	PROPN
dpc-5329	283	6	,	,	PUNCT
dpc-5329	283	7	fallon	fallon	PROPN
dpc-5329	283	8	pg	pg	PROPN
dpc-5329	283	9	,	,	PUNCT
dpc-5329	283	10	schwartz	schwartz	PROPN
dpc-5329	283	11	c.	c.	PROPN
dpc-5329	283	12	break	break	VERB
dpc-5329	283	13	on	on	ADP
dpc-5329	283	14	through	through	ADP
dpc-5329	283	15	:	:	PUNCT
dpc-5329	283	16	the	the	DET
dpc-5329	283	17	role	role	NOUN
dpc-5329	283	18	of	of	ADP
dpc-5329	283	19	innate	innate	ADJ
dpc-5329	283	20	immunity	immunity	NOUN
dpc-5329	283	21	and	and	CCONJ
dpc-5329	283	22	barrier	barrier	NOUN
dpc-5329	283	23	defence	defence	NOUN
dpc-5329	283	24	in	in	ADP
dpc-5329	283	25	atopic	atopic	NOUN
dpc-5329	283	26	dermatitis	dermatitis	NOUN
dpc-5329	283	27	and	and	CCONJ
dpc-5329	283	28	psoriasis	psoriasis	NOUN
dpc-5329	283	29	.	.	PUNCT
dpc-5329	284	1	skin	skin	NOUN
dpc-5329	284	2	health	health	PROPN
dpc-5329	284	3	dis	dis	PROPN
dpc-5329	284	4	.	.	PUNCT
dpc-5329	285	1	2022;2(2):e99	2022;2(2):e99	X
dpc-5329	285	2	.	.	PUNCT
dpc-5329	285	3	doi:10.1002	doi:10.1002	NOUN
dpc-5329	285	4	/	/	SYM
dpc-5329	285	5	ski2.99	ski2.99	PROPN
dpc-5329	285	6	.	.	PUNCT
dpc-5329	286	1	pmid	pmid	NOUN
dpc-5329	286	2	:	:	PUNCT
dpc-5329	286	3	35677926	35677926	NUM
dpc-5329	286	4	14	14	NUM
dpc-5329	286	5	.	.	PUNCT
dpc-5329	287	1	quaresma	quaresma	PROPN
dpc-5329	287	2	jas	jas	PROPN
dpc-5329	287	3	.	.	PROPN
dpc-5329	287	4	organization	organization	NOUN
dpc-5329	287	5	of	of	ADP
dpc-5329	287	6	the	the	DET
dpc-5329	287	7	skin	skin	NOUN
dpc-5329	287	8	immune	immune	ADJ
dpc-5329	287	9	system	system	NOUN
dpc-5329	287	10	and	and	CCONJ
dpc-5329	287	11	compartmentalized	compartmentalized	ADJ
dpc-5329	287	12	immune	immune	ADJ
dpc-5329	287	13	responses	response	NOUN
dpc-5329	287	14	in	in	ADP
dpc-5329	287	15	infectious	infectious	ADJ
dpc-5329	287	16	diseases	disease	NOUN
dpc-5329	287	17	.	.	PUNCT
dpc-5329	288	1	clin	clin	PROPN
dpc-5329	288	2	microbiol	microbiol	PROPN
dpc-5329	288	3	rev	rev	VERB
dpc-5329	288	4	.	.	PROPN
dpc-5329	288	5	2019;32(4):e00034	2019;32(4):e00034	NUM
dpc-5329	288	6	-	-	SYM
dpc-5329	288	7	18	18	NUM
dpc-5329	288	8	.	.	PUNCT
dpc-5329	289	1	doi:10.1128	doi:10.1128	VERB
dpc-5329	289	2	/cmr.00034	/cmr.00034	NOUN
dpc-5329	289	3	-	-	PUNCT
dpc-5329	289	4	18	18	NUM
dpc-5329	289	5	.	.	PUNCT
dpc-5329	290	1	pmid	pmid	NOUN
dpc-5329	290	2	:	:	PUNCT
dpc-5329	290	3	31366611	31366611	NUM
dpc-5329	290	4	15	15	NUM
dpc-5329	290	5	.	.	PUNCT
dpc-5329	291	1	nguyen	nguyen	PROPN
dpc-5329	291	2	av	av	PROPN
dpc-5329	291	3	,	,	PUNCT
dpc-5329	291	4	soulika	soulika	PROPN
dpc-5329	291	5	am	am	PROPN
dpc-5329	291	6	.	.	PUNCT
dpc-5329	292	1	the	the	DET
dpc-5329	292	2	dynamics	dynamic	NOUN
dpc-5329	292	3	of	of	ADP
dpc-5329	292	4	the	the	DET
dpc-5329	292	5	skin	skin	NOUN
dpc-5329	292	6	’s	’s	PART
dpc-5329	292	7	immune	immune	ADJ
dpc-5329	292	8	system	system	NOUN
dpc-5329	292	9	.	.	PUNCT
dpc-5329	293	1	int	int	PROPN
dpc-5329	293	2	j	j	PROPN
dpc-5329	293	3	mol	mol	ADP
dpc-5329	293	4	sci	sci	PROPN
dpc-5329	293	5	.	.	PUNCT
dpc-5329	294	1	2019;20(8):1811	2019;20(8):1811	NUM
dpc-5329	294	2	.	.	PUNCT
dpc-5329	295	1	doi:10.3390	doi:10.3390	NOUN
dpc-5329	295	2	/ijms20081811	/ijms20081811	PUNCT
dpc-5329	295	3	.	.	PUNCT
dpc-5329	296	1	pmid	pmid	NOUN
dpc-5329	296	2	:	:	PUNCT
dpc-5329	296	3	31013709	31013709	NUM
dpc-5329	296	4	16	16	NUM
dpc-5329	296	5	.	.	PUNCT
dpc-5329	297	1	sun	sun	PROPN
dpc-5329	297	2	n	n	CCONJ
dpc-5329	297	3	,	,	PUNCT
dpc-5329	297	4	ogulur	ogulur	VERB
dpc-5329	297	5	i	i	PROPN
dpc-5329	297	6	,	,	PUNCT
dpc-5329	297	7	mitamura	mitamura	PROPN
dpc-5329	297	8	y	y	PROPN
dpc-5329	297	9	,	,	PUNCT
dpc-5329	297	10	et	et	PROPN
dpc-5329	297	11	al	al	PROPN
dpc-5329	297	12	.	.	PUNCT
dpc-5329	298	1	the	the	DET
dpc-5329	298	2	epithelial	epithelial	ADJ
dpc-5329	298	3	barrier	barrier	NOUN
dpc-5329	298	4	theory	theory	NOUN
dpc-5329	298	5	and	and	CCONJ
dpc-5329	298	6	its	its	PRON
dpc-5329	298	7	associated	associated	ADJ
dpc-5329	298	8	diseases	disease	NOUN
dpc-5329	298	9	.	.	PUNCT
dpc-5329	299	1	allergy	allergy	NOUN
dpc-5329	299	2	.	.	PUNCT
dpc-5329	300	1	n	n	CCONJ
dpc-5329	300	2	/	/	SYM
dpc-5329	300	3	a(n	a(n	NOUN
dpc-5329	300	4	/	/	SYM
dpc-5329	300	5	a	a	NOUN
dpc-5329	300	6	)	)	PUNCT
dpc-5329	300	7	.	.	PUNCT
dpc-5329	301	1	doi:10.1111	doi:10.1111	PROPN
dpc-5329	301	2	/all.16318	/all.16318	PUNCT
dpc-5329	302	1	17	17	NUM
dpc-5329	302	2	.	.	PUNCT
dpc-5329	303	1	kim	kim	PROPN
dpc-5329	303	2	be	be	PROPN
dpc-5329	303	3	,	,	PUNCT
dpc-5329	303	4	leung	leung	PROPN
dpc-5329	303	5	dy	dy	PROPN
dpc-5329	303	6	.	.	PROPN
dpc-5329	303	7	significance	significance	NOUN
dpc-5329	303	8	of	of	ADP
dpc-5329	303	9	skin	skin	NOUN
dpc-5329	303	10	barrier	barrier	NOUN
dpc-5329	303	11	dysfunction	dysfunction	NOUN
dpc-5329	303	12	in	in	ADP
dpc-5329	303	13	atopic	atopic	NOUN
dpc-5329	303	14	dermatitis	dermatitis	NOUN
dpc-5329	303	15	.	.	PUNCT
dpc-5329	304	1	allergy	allergy	PROPN
dpc-5329	304	2	,	,	PUNCT
dpc-5329	304	3	asthma	asthma	PROPN
dpc-5329	304	4	&	&	CCONJ
dpc-5329	304	5	immunology	immunology	NOUN
dpc-5329	304	6	research	research	NOUN
dpc-5329	304	7	.	.	PUNCT
dpc-5329	305	1	2018;10(3):207	2018;10(3):207	NOUN
dpc-5329	305	2	.	.	PUNCT
dpc-5329	306	1	doi:10.4168	doi:10.4168	NOUN
dpc-5329	306	2	/	/	SYM
dpc-5329	306	3	aair.2018.10.3.207	aair.2018.10.3.207	NOUN
dpc-5329	306	4	.	.	PUNCT
dpc-5329	307	1	pmid	pmid	NOUN
dpc-5329	307	2	:	:	PUNCT
dpc-5329	307	3	29676067	29676067	NUM
dpc-5329	307	4	18	18	NUM
dpc-5329	307	5	.	.	PUNCT
dpc-5329	307	6	çetinarslan	çetinarslan	PROPN
dpc-5329	307	7	t	t	PROPN
dpc-5329	307	8	,	,	PUNCT
dpc-5329	307	9	kümper	kümper	PROPN
dpc-5329	307	10	l	l	NOUN
dpc-5329	307	11	,	,	PUNCT
dpc-5329	307	12	fölster	fölster	NOUN
dpc-5329	307	13	-	-	PUNCT
dpc-5329	307	14	holst	holst	NOUN
dpc-5329	307	15	r.	r.	NOUN
dpc-5329	307	16	the	the	DET
dpc-5329	307	17	immunological	immunological	ADJ
dpc-5329	307	18	and	and	CCONJ
dpc-5329	307	19	structural	structural	ADJ
dpc-5329	307	20	epidermal	epidermal	ADJ
dpc-5329	307	21	barrier	barrier	NOUN
dpc-5329	307	22	dysfunction	dysfunction	NOUN
dpc-5329	307	23	and	and	CCONJ
dpc-5329	307	24	skin	skin	NOUN
dpc-5329	307	25	microbiome	microbiome	NOUN
dpc-5329	307	26	in	in	ADP
dpc-5329	307	27	atopic	atopic	NOUN
dpc-5329	307	28	dermatitis	dermatitis	NOUN
dpc-5329	307	29	-	-	PUNCT
dpc-5329	307	30	an	an	DET
dpc-5329	307	31	update	update	NOUN
dpc-5329	307	32	.	.	PUNCT
dpc-5329	308	1	front	front	NOUN
dpc-5329	308	2	mol	mol	ADP
dpc-5329	308	3	biosci	biosci	PROPN
dpc-5329	308	4	.	.	PUNCT
dpc-5329	309	1	2023;10:1159404	2023;10:1159404	NUM
dpc-5329	309	2	.	.	PUNCT
dpc-5329	309	3	doi:10.3389	doi:10.3389	PROPN
dpc-5329	309	4	/	/	SYM
dpc-5329	309	5	fmolb.2023.1159404	fmolb.2023.1159404	PROPN
dpc-5329	309	6	19	19	NUM
dpc-5329	309	7	.	.	PUNCT
dpc-5329	310	1	kim	kim	PROPN
dpc-5329	310	2	j	j	PROPN
dpc-5329	310	3	,	,	PUNCT
dpc-5329	310	4	kim	kim	PROPN
dpc-5329	310	5	be	be	PROPN
dpc-5329	310	6	,	,	PUNCT
dpc-5329	310	7	leung	leung	PROPN
dpc-5329	310	8	dym	dym	PROPN
dpc-5329	310	9	.	.	PROPN
dpc-5329	310	10	pathophysiology	pathophysiology	PROPN
dpc-5329	310	11	of	of	ADP
dpc-5329	310	12	atopic	atopic	NOUN
dpc-5329	310	13	dermatitis	dermatitis	NOUN
dpc-5329	310	14	:	:	PUNCT
dpc-5329	310	15	clinical	clinical	ADJ
dpc-5329	310	16	implications	implication	NOUN
dpc-5329	310	17	.	.	PUNCT
dpc-5329	311	1	allergy	allergy	NOUN
dpc-5329	311	2	and	and	CCONJ
dpc-5329	311	3	asthma	asthma	PROPN
dpc-5329	311	4	proceedings	proceeding	NOUN
dpc-5329	311	5	.	.	PUNCT
dpc-5329	312	1	2019;40(2):84	2019;40(2):84	X
dpc-5329	312	2	.	.	PUNCT
dpc-5329	312	3	doi:10.2500	doi:10.2500	PROPN
dpc-5329	312	4	/	/	SYM
dpc-5329	312	5	aap.2019.40.4202	aap.2019.40.4202	PROPN
dpc-5329	312	6	.	.	PUNCT
dpc-5329	313	1	pmid	pmid	NOUN
dpc-5329	313	2	:	:	PUNCT
dpc-5329	313	3	30819278	30819278	NUM
dpc-5329	313	4	20	20	NUM
dpc-5329	313	5	.	.	PUNCT
dpc-5329	314	1	liu	liu	PROPN
dpc-5329	314	2	aw	aw	PROPN
dpc-5329	314	3	,	,	PUNCT
dpc-5329	314	4	gillis	gillis	PROPN
dpc-5329	314	5	je	je	PROPN
dpc-5329	314	6	,	,	PUNCT
dpc-5329	314	7	sumpter	sumpter	PROPN
dpc-5329	314	8	tl	tl	PROPN
dpc-5329	314	9	,	,	PUNCT
dpc-5329	314	10	kaplan	kaplan	PROPN
dpc-5329	314	11	dh	dh	PROPN
dpc-5329	314	12	.	.	PUNCT
dpc-5329	315	1	neuroimmune	neuroimmune	PROPN
dpc-5329	315	2	interactions	interaction	NOUN
dpc-5329	315	3	in	in	ADP
dpc-5329	315	4	atopic	atopic	NOUN
dpc-5329	315	5	and	and	CCONJ
dpc-5329	315	6	allergic	allergic	ADJ
dpc-5329	315	7	contact	contact	NOUN
dpc-5329	315	8	dermatitis	dermatitis	NOUN
dpc-5329	315	9	.	.	PUNCT
dpc-5329	316	1	the	the	DET
dpc-5329	316	2	journal	journal	PROPN
dpc-5329	316	3	of	of	ADP
dpc-5329	316	4	allergy	allergy	NOUN
dpc-5329	316	5	and	and	CCONJ
dpc-5329	316	6	clinical	clinical	ADJ
dpc-5329	316	7	immunology	immunology	NOUN
dpc-5329	316	8	.	.	PUNCT
dpc-5329	317	1	2023;151(5):1169	2023;151(5):1169	X
dpc-5329	317	2	.	.	PUNCT
dpc-5329	317	3	doi:10.1016	doi:10.1016	PROPN
dpc-5329	317	4	/	/	SYM
dpc-5329	317	5	j.jaci.2023.03.013	j.jaci.2023.03.013	PROPN
dpc-5329	317	6	.	.	PUNCT
dpc-5329	318	1	pmid	pmid	NOUN
dpc-5329	318	2	:	:	PUNCT
dpc-5329	318	3	37149370	37149370	NUM
dpc-5329	318	4	21	21	NUM
dpc-5329	318	5	.	.	PUNCT
dpc-5329	319	1	santamaria	santamaria	PROPN
dpc-5329	319	2	-	-	PUNCT
dpc-5329	319	3	babí	babí	NOUN
dpc-5329	319	4	lf	lf	PROPN
dpc-5329	319	5	.	.	PUNCT
dpc-5329	319	6	atopic	atopic	PROPN
dpc-5329	319	7	dermatitis	dermatitis	NOUN
dpc-5329	319	8	pathogenesis	pathogenesis	NOUN
dpc-5329	319	9	:	:	PUNCT
dpc-5329	319	10	lessons	lesson	NOUN
dpc-5329	319	11	from	from	ADP
dpc-5329	319	12	immunology	immunology	NOUN
dpc-5329	319	13	.	.	PUNCT
dpc-5329	320	1	dermatology	dermatology	NOUN
dpc-5329	320	2	practical	practical	ADJ
dpc-5329	320	3	&	&	CCONJ
dpc-5329	320	4	conceptual	conceptual	ADJ
dpc-5329	320	5	.	.	PUNCT
dpc-5329	321	1	2022;12(1):e2022152	2022;12(1):e2022152	NUM
dpc-5329	321	2	.	.	PUNCT
dpc-5329	321	3	doi:10.5826	doi:10.5826	PROPN
dpc-5329	321	4	/	/	SYM
dpc-5329	322	1	dpc.1201a152	dpc.1201a152	PROPN
dpc-5329	322	2	.	.	PUNCT
dpc-5329	323	1	pmid	pmid	PROPN
dpc-5329	323	2	:	:	PUNCT
dpc-5329	323	3	35223190	35223190	NUM
dpc-5329	323	4	22	22	NUM
dpc-5329	323	5	.	.	PUNCT
dpc-5329	324	1	legat	legat	PROPN
dpc-5329	324	2	fj	fj	PROPN
dpc-5329	324	3	.	.	PUNCT
dpc-5329	324	4	itch	itch	PROPN
dpc-5329	324	5	in	in	ADP
dpc-5329	324	6	atopic	atopic	NOUN
dpc-5329	324	7	dermatitis	dermatitis	NOUN
dpc-5329	324	8	–	–	PUNCT
dpc-5329	324	9	what	what	PRON
dpc-5329	324	10	is	be	AUX
dpc-5329	324	11	new	new	ADJ
dpc-5329	324	12	?	?	PUNCT
dpc-5329	325	1	frontiers	frontier	NOUN
dpc-5329	325	2	in	in	ADP
dpc-5329	325	3	medicine	medicine	NOUN
dpc-5329	325	4	.	.	PUNCT
dpc-5329	326	1	2021;8:644760	2021;8:644760	NOUN
dpc-5329	326	2	.	.	PUNCT
dpc-5329	327	1	doi:10.3389	doi:10.3389	PROPN
dpc-5329	327	2	/	/	SYM
dpc-5329	328	1	fmed.2021.644760	fmed.2021.644760	PROPN
dpc-5329	328	2	.	.	PUNCT
dpc-5329	329	1	pmid	pmid	NOUN
dpc-5329	329	2	:	:	PUNCT
dpc-5329	329	3	34026782	34026782	NUM
dpc-5329	329	4	23	23	NUM
dpc-5329	329	5	.	.	PUNCT
dpc-5329	330	1	hülpüsch	hülpüsch	PROPN
dpc-5329	330	2	c	c	X
dpc-5329	330	3	,	,	PUNCT
dpc-5329	330	4	rohayem	rohayem	ADJ
dpc-5329	330	5	r	r	NOUN
dpc-5329	330	6	,	,	PUNCT
dpc-5329	330	7	reiger	reiger	NOUN
dpc-5329	330	8	m	m	PROPN
dpc-5329	330	9	,	,	PUNCT
dpc-5329	330	10	traidl	traidl	PROPN
dpc-5329	330	11	-	-	PUNCT
dpc-5329	330	12	hoffmann	hoffmann	PROPN
dpc-5329	330	13	c.	c.	PROPN
dpc-5329	330	14	exploring	explore	VERB
dpc-5329	330	15	the	the	DET
dpc-5329	330	16	skin	skin	NOUN
dpc-5329	330	17	microbiome	microbiome	NOUN
dpc-5329	330	18	in	in	ADP
dpc-5329	330	19	atopic	atopic	NOUN
dpc-5329	330	20	dermatitis	dermatitis	NOUN
dpc-5329	330	21	pathogenesis	pathogenesis	NOUN
dpc-5329	330	22	and	and	CCONJ
dpc-5329	330	23	disease	disease	NOUN
dpc-5329	330	24	modification	modification	NOUN
dpc-5329	330	25	.	.	PUNCT
dpc-5329	331	1	journal	journal	PROPN
dpc-5329	331	2	of	of	ADP
dpc-5329	331	3	allergy	allergy	NOUN
dpc-5329	331	4	and	and	CCONJ
dpc-5329	331	5	clinical	clinical	ADJ
dpc-5329	331	6	immunology	immunology	NOUN
dpc-5329	331	7	.	.	PUNCT
dpc-5329	332	1	2024;154(1):31	2024;154(1):31	NUM
dpc-5329	332	2	-	-	SYM
dpc-5329	332	3	41	41	NUM
dpc-5329	332	4	.	.	PUNCT
dpc-5329	333	1	doi:10.1016	doi:10.1016	PROPN
dpc-5329	333	2	/	/	SYM
dpc-5329	333	3	j.jaci.2024.04.029	j.jaci.2024.04.029	PROPN
dpc-5329	333	4	24	24	NUM
dpc-5329	333	5	.	.	PUNCT
dpc-5329	334	1	boguniewicz	boguniewicz	PROPN
dpc-5329	334	2	m	m	PROPN
dpc-5329	334	3	,	,	PUNCT
dpc-5329	334	4	leung	leung	PROPN
dpc-5329	334	5	dy	dy	PROPN
dpc-5329	334	6	.	.	PROPN
dpc-5329	334	7	atopic	atopic	PROPN
dpc-5329	334	8	dermatitis	dermatitis	PROPN
dpc-5329	334	9	:	:	PUNCT
dpc-5329	334	10	a	a	DET
dpc-5329	334	11	disease	disease	NOUN
dpc-5329	334	12	of	of	ADP
dpc-5329	334	13	altered	altered	ADJ
dpc-5329	334	14	skin	skin	NOUN
dpc-5329	334	15	barrier	barrier	NOUN
dpc-5329	334	16	and	and	CCONJ
dpc-5329	334	17	immune	immune	ADJ
dpc-5329	334	18	dysregulation	dysregulation	NOUN
dpc-5329	334	19	.	.	PUNCT
dpc-5329	335	1	immunol	immunol	PROPN
dpc-5329	335	2	rev	rev	PROPN
dpc-5329	335	3	.	.	PROPN
dpc-5329	335	4	2011;242(1):233	2011;242(1):233	NUM
dpc-5329	335	5	-	-	SYM
dpc-5329	335	6	246	246	NUM
dpc-5329	335	7	.	.	PUNCT
dpc-5329	336	1	doi:10.1111	doi:10.1111	ADJ
dpc-5329	336	2	/	/	SYM
dpc-5329	336	3	j.1600	j.1600	NOUN
dpc-5329	336	4	-	-	PUNCT
dpc-5329	336	5	065x	065x	PROPN
dpc-5329	336	6	.	.	PUNCT
dpc-5329	337	1	2011.01027.x	2011.01027.x	NOUN
dpc-5329	337	2	.	.	PUNCT
dpc-5329	338	1	pmid	pmid	NOUN
dpc-5329	338	2	:	:	PUNCT
dpc-5329	338	3	21682749	21682749	NUM
dpc-5329	338	4	25	25	NUM
dpc-5329	338	5	.	.	PUNCT
dpc-5329	339	1	shirley	shirley	PROPN
dpc-5329	339	2	sn	sn	PROPN
dpc-5329	339	3	,	,	PUNCT
dpc-5329	339	4	watson	watson	PROPN
dpc-5329	339	5	ae	ae	PROPN
dpc-5329	339	6	,	,	PUNCT
dpc-5329	339	7	yusuf	yusuf	PROPN
dpc-5329	339	8	n.	n.	PROPN
dpc-5329	339	9	pathogenesis	pathogenesis	PROPN
dpc-5329	339	10	of	of	ADP
dpc-5329	339	11	inflammation	inflammation	NOUN
dpc-5329	339	12	in	in	ADP
dpc-5329	339	13	skin	skin	NOUN
dpc-5329	339	14	disease	disease	NOUN
dpc-5329	339	15	:	:	PUNCT
dpc-5329	339	16	from	from	ADP
dpc-5329	339	17	molecular	molecular	ADJ
dpc-5329	339	18	mechanisms	mechanism	NOUN
dpc-5329	339	19	to	to	ADP
dpc-5329	339	20	pathology	pathology	NOUN
dpc-5329	339	21	.	.	PUNCT
dpc-5329	340	1	international	international	ADJ
dpc-5329	340	2	journal	journal	NOUN
dpc-5329	340	3	of	of	ADP
dpc-5329	340	4	molecular	molecular	ADJ
dpc-5329	340	5	sciences	science	NOUN
dpc-5329	340	6	.	.	PUNCT
dpc-5329	341	1	2024;25(18):10152	2024;25(18):10152	NUM
dpc-5329	341	2	.	.	PUNCT
dpc-5329	341	3	doi:10.3390	doi:10.3390	PROPN
dpc-5329	341	4	/	/	SYM
dpc-5329	341	5	ijms251810152	ijms251810152	PROPN
dpc-5329	341	6	.	.	PUNCT
dpc-5329	342	1	pmid	pmid	NOUN
dpc-5329	342	2	:	:	PUNCT
dpc-5329	342	3	39337637	39337637	NUM
dpc-5329	342	4	8	8	NUM
dpc-5329	342	5	review	review	NOUN
dpc-5329	342	6	|	|	ADV
dpc-5329	342	7	dermatol	dermatol	ADJ
dpc-5329	342	8	pract	pract	NOUN
dpc-5329	342	9	concept	concept	NOUN
dpc-5329	342	10	.	.	PUNCT
dpc-5329	343	1	2025;15(4):5329	2025;15(4):5329	NUM
dpc-5329	343	2	45	45	NUM
dpc-5329	343	3	.	.	PUNCT
dpc-5329	344	1	ständer	ständer	PROPN
dpc-5329	344	2	s	s	PROPN
dpc-5329	344	3	,	,	PUNCT
dpc-5329	344	4	siepmann	siepmann	NOUN
dpc-5329	345	1	d	d	NOUN
dpc-5329	345	2	,	,	PUNCT
dpc-5329	345	3	herrgott	herrgott	PROPN
dpc-5329	345	4	i	i	PROPN
dpc-5329	345	5	,	,	PUNCT
dpc-5329	345	6	sunderkötter	sunderkötter	PROPN
dpc-5329	345	7	c	c	PROPN
dpc-5329	345	8	,	,	PUNCT
dpc-5329	345	9	luger	luger	PROPN
dpc-5329	345	10	ta	ta	PROPN
dpc-5329	345	11	.	.	PUNCT
dpc-5329	346	1	targeting	target	VERB
dpc-5329	346	2	the	the	DET
dpc-5329	346	3	neurokinin	neurokinin	ADJ
dpc-5329	346	4	receptor	receptor	NOUN
dpc-5329	346	5	1	1	NUM
dpc-5329	346	6	with	with	ADP
dpc-5329	346	7	aprepitant	aprepitant	ADJ
dpc-5329	346	8	:	:	PUNCT
dpc-5329	346	9	a	a	DET
dpc-5329	346	10	novel	novel	ADJ
dpc-5329	346	11	antipruritic	antipruritic	ADJ
dpc-5329	346	12	strategy	strategy	NOUN
dpc-5329	346	13	.	.	PUNCT
dpc-5329	347	1	plos	plos	PROPN
dpc-5329	347	2	one	one	NUM
dpc-5329	347	3	.	.	PUNCT
dpc-5329	348	1	2010;5(6):e10968	2010;5(6):e10968	X
dpc-5329	348	2	.	.	PUNCT
dpc-5329	349	1	doi:10.1371	doi:10.1371	PROPN
dpc-5329	349	2	/	/	SYM
dpc-5329	350	1	journal.pone.0010968	journal.pone.0010968	PROPN
dpc-5329	350	2	.	.	PUNCT
dpc-5329	351	1	pmid	pmid	PROPN
dpc-5329	351	2	:	:	PUNCT
dpc-5329	351	3	20532044	20532044	NUM
dpc-5329	351	4	46	46	NUM
dpc-5329	351	5	.	.	PUNCT
dpc-5329	352	1	müller	müller	PROPN
dpc-5329	352	2	s	s	PROPN
dpc-5329	352	3	,	,	PUNCT
dpc-5329	352	4	maintz	maintz	PROPN
dpc-5329	352	5	l	l	PROPN
dpc-5329	352	6	,	,	PUNCT
dpc-5329	352	7	bieber	bieber	PROPN
dpc-5329	352	8	t.	t.	NOUN
dpc-5329	352	9	treatment	treatment	NOUN
dpc-5329	352	10	of	of	ADP
dpc-5329	352	11	atopic	atopic	NOUN
dpc-5329	352	12	dermatitis	dermatitis	NOUN
dpc-5329	352	13	:	:	PUNCT
dpc-5329	352	14	recently	recently	ADV
dpc-5329	352	15	approved	approve	VERB
dpc-5329	352	16	drugs	drug	NOUN
dpc-5329	352	17	and	and	CCONJ
dpc-5329	352	18	advanced	advanced	ADJ
dpc-5329	352	19	clinical	clinical	ADJ
dpc-5329	352	20	development	development	NOUN
dpc-5329	352	21	programs	program	NOUN
dpc-5329	352	22	.	.	PUNCT
dpc-5329	353	1	allergy	allergy	NOUN
dpc-5329	353	2	.	.	PUNCT
dpc-5329	354	1	2024;79(6):1501	2024;79(6):1501	NUM
dpc-5329	354	2	-	-	SYM
dpc-5329	354	3	1515	1515	NUM
dpc-5329	354	4	.	.	PUNCT
dpc-5329	355	1	doi:10.1111	doi:10.1111	ADJ
dpc-5329	355	2	/	/	SYM
dpc-5329	355	3	all.16009	all.16009	X
dpc-5329	355	4	47	47	NUM
dpc-5329	355	5	.	.	PUNCT
dpc-5329	356	1	paz	paz	PROPN
dpc-5329	356	2	m	m	PROPN
dpc-5329	356	3	,	,	PUNCT
dpc-5329	356	4	lio	lio	PROPN
dpc-5329	356	5	p.	p.	NOUN
dpc-5329	356	6	figure	figure	NOUN
dpc-5329	356	7	1	1	NUM
dpc-5329	356	8	.	.	PUNCT
dpc-5329	357	1	the	the	DET
dpc-5329	357	2	nice	nice	ADJ
dpc-5329	357	3	system	system	NOUN
dpc-5329	357	4	and	and	CCONJ
dpc-5329	357	5	gut	gut	NOUN
dpc-5329	357	6	-	-	PUNCT
dpc-5329	357	7	skin	skin	NOUN
dpc-5329	357	8	axis	axis	NOUN
dpc-5329	357	9	.	.	PUNCT
dpc-5329	358	1	created	create	VERB
dpc-5329	358	2	in	in	ADP
dpc-5329	358	3	biorender	biorender	NOUN
dpc-5329	358	4	.	.	PUNCT
dpc-5329	359	1	https://biorender.com/m74v423	https://biorender.com/m74v423	NOUN
dpc-5329	359	2	.	.	NOUN
dpc-5329	360	1	48	48	NUM
dpc-5329	360	2	.	.	PUNCT
dpc-5329	361	1	paz	paz	PROPN
dpc-5329	361	2	m	m	PROPN
dpc-5329	361	3	,	,	PUNCT
dpc-5329	361	4	lio	lio	PROPN
dpc-5329	361	5	p.	p.	PROPN
dpc-5329	361	6	skin	skin	NOUN
dpc-5329	361	7	-	-	PUNCT
dpc-5329	361	8	immune	immune	NOUN
dpc-5329	361	9	-	-	PUNCT
dpc-5329	361	10	neuro	neuro	NOUN
dpc-5329	361	11	-	-	PUNCT
dpc-5329	361	12	gastro	gastro	NOUN
dpc-5329	361	13	-	-	PUNCT
dpc-5329	361	14	endocrine	endocrine	NOUN
dpc-5329	361	15	(	(	PUNCT
dpc-5329	361	16	singe	singe	NOUN
dpc-5329	361	17	)	)	PUNCT
dpc-5329	361	18	system	system	NOUN
dpc-5329	361	19	:	:	PUNCT
dpc-5329	361	20	lighting	light	VERB
dpc-5329	361	21	the	the	DET
dpc-5329	361	22	fire	fire	NOUN
dpc-5329	361	23	on	on	ADP
dpc-5329	361	24	ad	ad	NOUN
dpc-5329	361	25	research	research	NOUN
dpc-5329	361	26	.	.	PUNCT
dpc-5329	362	1	created	create	VERB
dpc-5329	362	2	in	in	ADP
dpc-5329	362	3	biorender	biorender	NOUN
dpc-5329	362	4	.	.	PUNCT
dpc-5329	363	1	https://biorender.com/o95m463	https://biorender.com/o95m463	ADJ
dpc-5329	363	2	49	49	NUM
dpc-5329	363	3	.	.	PUNCT
dpc-5329	364	1	paz	paz	PROPN
dpc-5329	364	2	m	m	PROPN
dpc-5329	364	3	,	,	PUNCT
dpc-5329	364	4	lio	lio	PROPN
dpc-5329	364	5	p.	p.	NOUN
dpc-5329	364	6	figure	figure	NOUN
dpc-5329	364	7	3	3	NUM
dpc-5329	364	8	.	.	X
dpc-5329	364	9	pathophysiology	pathophysiology	NOUN
dpc-5329	364	10	of	of	ADP
dpc-5329	364	11	atopic	atopic	NOUN
dpc-5329	364	12	dermatitis	dermatitis	NOUN
dpc-5329	364	13	.	.	PUNCT
dpc-5329	365	1	created	create	VERB
dpc-5329	365	2	in	in	ADP
dpc-5329	365	3	biorender	biorender	NOUN
dpc-5329	365	4	.	.	PUNCT
dpc-5329	366	1	https://biorender.com/j21v81	https://biorender.com/j21v81	X
dpc-5329	366	2	.	.	PUNCT
dpc-5329	367	1	50	50	NUM
dpc-5329	367	2	.	.	PUNCT
dpc-5329	368	1	paz	paz	PROPN
dpc-5329	368	2	m	m	PROPN
dpc-5329	368	3	,	,	PUNCT
dpc-5329	368	4	lio	lio	PROPN
dpc-5329	368	5	p.	p.	NOUN
dpc-5329	368	6	figure	figure	NOUN
dpc-5329	368	7	4	4	NUM
dpc-5329	368	8	.	.	PUNCT
dpc-5329	369	1	the	the	DET
dpc-5329	369	2	itch	itch	NOUN
dpc-5329	369	3	-	-	PUNCT
dpc-5329	369	4	scratch	scratch	NOUN
dpc-5329	369	5	cycle	cycle	NOUN
dpc-5329	369	6	.	.	PUNCT
dpc-5329	369	7	created	create	VERB
dpc-5329	369	8	in	in	ADP
dpc-5329	369	9	biorender	biorender	NOUN
dpc-5329	369	10	.	.	PUNCT
dpc-5329	370	1	https://biorender.com/u93x140	https://biorender.com/u93x140	PROPN
dpc-5329	370	2	.	.	PROPN
dpc-5329	370	3	journal	journal	NOUN
dpc-5329	370	4	of	of	ADP
dpc-5329	370	5	molecular	molecular	ADJ
dpc-5329	370	6	sciences	science	NOUN
dpc-5329	370	7	.	.	PUNCT
dpc-5329	371	1	2021;22(11):5750	2021;22(11):5750	X
dpc-5329	371	2	.	.	PUNCT
dpc-5329	371	3	doi:10.3390	doi:10.3390	NOUN
dpc-5329	371	4	/ijms22115750	/ijms22115750	PUNCT
dpc-5329	371	5	.	.	PUNCT
dpc-5329	372	1	pmid	pmid	NOUN
dpc-5329	372	2	:	:	PUNCT
dpc-5329	372	3	34072239	34072239	NUM
dpc-5329	372	4	41	41	NUM
dpc-5329	372	5	.	.	PUNCT
dpc-5329	373	1	frazier	frazier	PROPN
dpc-5329	373	2	w	w	PROPN
dpc-5329	373	3	,	,	PUNCT
dpc-5329	373	4	bhardwaj	bhardwaj	PROPN
dpc-5329	373	5	n.	n.	PROPN
dpc-5329	373	6	atopic	atopic	PROPN
dpc-5329	373	7	dermatitis	dermatitis	PROPN
dpc-5329	373	8	:	:	PUNCT
dpc-5329	373	9	diagnosis	diagnosis	NOUN
dpc-5329	373	10	and	and	CCONJ
dpc-5329	373	11	treatment	treatment	NOUN
dpc-5329	373	12	.	.	PUNCT
dpc-5329	374	1	afp	afp	PROPN
dpc-5329	374	2	.	.	PUNCT
dpc-5329	375	1	2020;101(10):590	2020;101(10):590	NUM
dpc-5329	375	2	-	-	SYM
dpc-5329	375	3	598	598	NUM
dpc-5329	375	4	.	.	PUNCT
dpc-5329	376	1	42	42	NUM
dpc-5329	376	2	.	.	PUNCT
dpc-5329	377	1	lugović	lugović	PROPN
dpc-5329	377	2	-	-	PUNCT
dpc-5329	377	3	mihić	mihić	PROPN
dpc-5329	377	4	l	l	PROPN
dpc-5329	377	5	,	,	PUNCT
dpc-5329	377	6	meštrović	meštrović	VERB
dpc-5329	377	7	-	-	PUNCT
dpc-5329	377	8	štefekov	štefekov	PROPN
dpc-5329	377	9	j	j	PROPN
dpc-5329	377	10	,	,	PUNCT
dpc-5329	377	11	potočnjak	potočnjak	PROPN
dpc-5329	377	12	i	i	PROPN
dpc-5329	377	13	,	,	PUNCT
dpc-5329	377	14	et	et	PROPN
dpc-5329	377	15	al	al	PROPN
dpc-5329	377	16	.	.	PUNCT
dpc-5329	377	17	atopic	atopic	PROPN
dpc-5329	377	18	dermatitis	dermatitis	PROPN
dpc-5329	377	19	:	:	PUNCT
dpc-5329	377	20	disease	disease	NOUN
dpc-5329	377	21	features	feature	VERB
dpc-5329	377	22	,	,	PUNCT
dpc-5329	377	23	therapeutic	therapeutic	ADJ
dpc-5329	377	24	options	option	NOUN
dpc-5329	377	25	,	,	PUNCT
dpc-5329	377	26	and	and	CCONJ
dpc-5329	377	27	a	a	DET
dpc-5329	377	28	multidisciplinary	multidisciplinary	ADJ
dpc-5329	377	29	approach	approach	NOUN
dpc-5329	377	30	.	.	PUNCT
dpc-5329	378	1	life	life	NOUN
dpc-5329	378	2	(	(	PUNCT
dpc-5329	378	3	basel	basel	PROPN
dpc-5329	378	4	)	)	PUNCT
dpc-5329	378	5	.	.	PUNCT
dpc-5329	379	1	2023;13(6):1419	2023;13(6):1419	NUM
dpc-5329	379	2	.	.	PUNCT
dpc-5329	380	1	doi:10.3390	doi:10.3390	PROPN
dpc-5329	380	2	/	/	SYM
dpc-5329	380	3	life13061419	life13061419	PROPN
dpc-5329	380	4	.	.	PUNCT
dpc-5329	381	1	pmid	pmid	NOUN
dpc-5329	381	2	:	:	PUNCT
dpc-5329	381	3	37374201	37374201	NUM
dpc-5329	381	4	43	43	NUM
dpc-5329	381	5	.	.	PUNCT
dpc-5329	382	1	davari	davari	PROPN
dpc-5329	382	2	dr	dr	PROPN
dpc-5329	382	3	,	,	PUNCT
dpc-5329	382	4	nieman	nieman	PROPN
dpc-5329	382	5	el	el	PROPN
dpc-5329	382	6	,	,	PUNCT
dpc-5329	382	7	mcshane	mcshane	PROPN
dpc-5329	382	8	db	db	PROPN
dpc-5329	382	9	,	,	PUNCT
dpc-5329	382	10	morrell	morrell	PROPN
dpc-5329	382	11	ds	ds	PROPN
dpc-5329	382	12	.	.	PROPN
dpc-5329	382	13	current	current	ADJ
dpc-5329	382	14	perspectives	perspective	NOUN
dpc-5329	382	15	on	on	ADP
dpc-5329	382	16	the	the	DET
dpc-5329	382	17	systemic	systemic	ADJ
dpc-5329	382	18	management	management	NOUN
dpc-5329	382	19	of	of	ADP
dpc-5329	382	20	atopic	atopic	NOUN
dpc-5329	382	21	dermatitis	dermatitis	NOUN
dpc-5329	382	22	.	.	PUNCT
dpc-5329	383	1	j	j	PROPN
dpc-5329	383	2	asthma	asthma	PROPN
dpc-5329	383	3	allergy	allergy	PROPN
dpc-5329	383	4	.	.	PUNCT
dpc-5329	384	1	2021;14:595	2021;14:595	NUM
dpc-5329	384	2	-	-	SYM
dpc-5329	384	3	607	607	NUM
dpc-5329	384	4	.	.	PUNCT
dpc-5329	384	5	doi:10.2147	doi:10.2147	NOUN
dpc-5329	384	6	/	/	SYM
dpc-5329	384	7	jaa	jaa	PROPN
dpc-5329	384	8	.	.	PUNCT
dpc-5329	385	1	s287638	s287638	PROPN
dpc-5329	385	2	.	.	PUNCT
dpc-5329	386	1	pmid	pmid	NOUN
dpc-5329	386	2	:	:	PUNCT
dpc-5329	386	3	34103945	34103945	NUM
dpc-5329	386	4	44	44	NUM
dpc-5329	386	5	.	.	PUNCT
dpc-5329	387	1	kim	kim	PROPN
dpc-5329	387	2	yj	yj	PROPN
dpc-5329	387	3	,	,	PUNCT
dpc-5329	387	4	granstein	granstein	PROPN
dpc-5329	387	5	rd	rd	NOUN
dpc-5329	387	6	.	.	PUNCT
dpc-5329	387	7	roles	role	NOUN
dpc-5329	387	8	of	of	ADP
dpc-5329	387	9	calcitonin	calcitonin	ADJ
dpc-5329	387	10	gene	gene	NOUN
dpc-5329	387	11	-	-	PUNCT
dpc-5329	387	12	related	relate	VERB
dpc-5329	387	13	peptide	peptide	NOUN
dpc-5329	387	14	in	in	ADP
dpc-5329	387	15	the	the	DET
dpc-5329	387	16	skin	skin	NOUN
dpc-5329	387	17	,	,	PUNCT
dpc-5329	387	18	and	and	CCONJ
dpc-5329	387	19	other	other	ADJ
dpc-5329	387	20	physiological	physiological	ADJ
dpc-5329	387	21	and	and	CCONJ
dpc-5329	387	22	pathophysiological	pathophysiological	ADJ
dpc-5329	387	23	functions	function	NOUN
dpc-5329	387	24	.	.	PUNCT
dpc-5329	388	1	brain	brain	NOUN
dpc-5329	388	2	behav	behav	PROPN
dpc-5329	388	3	immun	immun	PROPN
dpc-5329	388	4	health	health	PROPN
dpc-5329	388	5	.	.	PUNCT
dpc-5329	389	1	2021;18:100361	2021;18:100361	X
dpc-5329	389	2	.	.	PUNCT
dpc-5329	389	3	doi:10.1016	doi:10.1016	PROPN
dpc-5329	389	4	/	/	SYM
dpc-5329	389	5	j.bbih.2021.100361	j.bbih.2021.100361	PROPN
dpc-5329	389	6	.	.	PUNCT
dpc-5329	390	1	pmid	pmid	NOUN
dpc-5329	390	2	:	:	PUNCT
dpc-5329	390	3	34746878	34746878	NUM