id	sid	tid	token	lemma	pos
dpc-539	1	1	dermatology	dermatology	NOUN
dpc-539	1	2	:	:	PUNCT
dpc-539	1	3	practical	practical	ADJ
dpc-539	1	4	and	and	CCONJ
dpc-539	1	5	conceptual	conceptual	ADJ
dpc-539	1	6	54	54	NUM
dpc-539	1	7	research	research	NOUN
dpc-539	1	8	|	|	ADV
dpc-539	1	9	dermatol	dermatol	NOUN
dpc-539	1	10	pract	pract	NOUN
dpc-539	1	11	concept	concept	NOUN
dpc-539	1	12	2019;9(1):13	2019;9(1):13	NUM
dpc-539	1	13	dermatology	dermatology	NOUN
dpc-539	1	14	practical	practical	ADJ
dpc-539	1	15	&	&	CCONJ
dpc-539	1	16	conceptual	conceptual	ADJ
dpc-539	1	17	braf	braf	NOUN
dpc-539	1	18	mutation	mutation	NOUN
dpc-539	1	19	status	status	NOUN
dpc-539	1	20	in	in	ADP
dpc-539	1	21	primary	primary	ADJ
dpc-539	1	22	,	,	PUNCT
dpc-539	1	23	recurrent	recurrent	NOUN
dpc-539	1	24	,	,	PUNCT
dpc-539	1	25	and	and	CCONJ
dpc-539	1	26	metastatic	metastatic	ADJ
dpc-539	1	27	malignant	malignant	ADJ
dpc-539	1	28	melanoma	melanoma	NOUN
dpc-539	1	29	and	and	CCONJ
dpc-539	1	30	its	its	PRON
dpc-539	1	31	relation	relation	NOUN
dpc-539	1	32	to	to	ADP
dpc-539	1	33	histopathological	histopathological	ADJ
dpc-539	1	34	parameters	parameter	NOUN
dpc-539	1	35	aris	aris	PROPN
dpc-539	1	36	spathis1	spathis1	PROPN
dpc-539	1	37	,	,	PUNCT
dpc-539	1	38	alexander	alexander	PROPN
dpc-539	1	39	c.	c.	PROPN
dpc-539	1	40	katoulis2	katoulis2	PROPN
dpc-539	1	41	,	,	PUNCT
dpc-539	1	42	vasileia	vasileia	NOUN
dpc-539	1	43	damaskou1	damaskou1	PROPN
dpc-539	1	44	,	,	PUNCT
dpc-539	1	45	aikaterini	aikaterini	PROPN
dpc-539	1	46	i.	i.	PROPN
dpc-539	1	47	liakou2	liakou2	PROPN
dpc-539	1	48	,	,	PUNCT
dpc-539	1	49	christine	christine	PROPN
dpc-539	1	50	kottaridi1	kottaridi1	PROPN
dpc-539	1	51	,	,	PUNCT
dpc-539	1	52	danai	danai	VERB
dpc-539	1	53	leventakou1	leventakou1	NOUN
dpc-539	1	54	,	,	PUNCT
dpc-539	1	55	dimitrios	dimitrio	NOUN
dpc-539	1	56	sgouros2	sgouros2	NOUN
dpc-539	1	57	,	,	PUNCT
dpc-539	1	58	andreas	andreas	PROPN
dpc-539	1	59	mamantopoulos3	mamantopoulos3	PROPN
dpc-539	1	60	,	,	PUNCT
dpc-539	1	61	dimitrios	dimitrios	ADJ
dpc-539	1	62	rigopoulos2	rigopoulos2	NOUN
dpc-539	1	63	,	,	PUNCT
dpc-539	1	64	petros	petros	PROPN
dpc-539	1	65	karakitsos4	karakitsos4	PROPN
dpc-539	1	66	,	,	PUNCT
dpc-539	2	1	ioannis	ioannis	PROPN
dpc-539	2	2	g.	g.	PROPN
dpc-539	2	3	panayiotides1	panayiotides1	PROPN
dpc-539	2	4	1	1	NUM
dpc-539	2	5	second	second	ADJ
dpc-539	2	6	department	department	NOUN
dpc-539	2	7	of	of	ADP
dpc-539	2	8	pathology	pathology	PROPN
dpc-539	2	9	,	,	PUNCT
dpc-539	2	10	national	national	ADJ
dpc-539	2	11	and	and	CCONJ
dpc-539	2	12	kapodistrian	kapodistrian	ADJ
dpc-539	2	13	university	university	PROPN
dpc-539	2	14	of	of	ADP
dpc-539	2	15	athens	athens	PROPN
dpc-539	2	16	,	,	PUNCT
dpc-539	2	17	school	school	NOUN
dpc-539	2	18	of	of	ADP
dpc-539	2	19	medicine	medicine	NOUN
dpc-539	2	20	,	,	PUNCT
dpc-539	2	21	attikon	attikon	ADJ
dpc-539	2	22	university	university	NOUN
dpc-539	2	23	hospital	hospital	NOUN
dpc-539	2	24	,	,	PUNCT
dpc-539	2	25	athens	athens	PROPN
dpc-539	2	26	,	,	PUNCT
dpc-539	2	27	greece	greece	PROPN
dpc-539	2	28	2	2	NUM
dpc-539	2	29	second	second	ADJ
dpc-539	2	30	department	department	NOUN
dpc-539	2	31	of	of	ADP
dpc-539	2	32	dermatology	dermatology	NOUN
dpc-539	2	33	and	and	CCONJ
dpc-539	2	34	venereology	venereology	NOUN
dpc-539	2	35	,	,	PUNCT
dpc-539	2	36	national	national	ADJ
dpc-539	2	37	and	and	CCONJ
dpc-539	2	38	kapodistrian	kapodistrian	ADJ
dpc-539	2	39	university	university	PROPN
dpc-539	2	40	of	of	ADP
dpc-539	2	41	athens	athens	PROPN
dpc-539	2	42	,	,	PUNCT
dpc-539	2	43	school	school	NOUN
dpc-539	2	44	of	of	ADP
dpc-539	2	45	medicine	medicine	NOUN
dpc-539	2	46	,	,	PUNCT
dpc-539	2	47	attikon	attikon	ADJ
dpc-539	2	48	university	university	NOUN
dpc-539	2	49	hospital	hospital	NOUN
dpc-539	2	50	,	,	PUNCT
dpc-539	2	51	athens	athens	PROPN
dpc-539	2	52	,	,	PUNCT
dpc-539	2	53	greece	greece	PROPN
dpc-539	2	54	3	3	NUM
dpc-539	2	55	department	department	NOUN
dpc-539	2	56	of	of	ADP
dpc-539	2	57	surgery	surgery	NOUN
dpc-539	2	58	,	,	PUNCT
dpc-539	2	59	ierapetra	ierapetra	ADJ
dpc-539	2	60	general	general	ADJ
dpc-539	2	61	hospital	hospital	NOUN
dpc-539	2	62	,	,	PUNCT
dpc-539	2	63	ierapetra	ierapetra	X
dpc-539	2	64	(	(	PUNCT
dpc-539	2	65	crete	crete	PROPN
dpc-539	2	66	)	)	PUNCT
dpc-539	2	67	,	,	PUNCT
dpc-539	2	68	greece	greece	PROPN
dpc-539	2	69	4	4	NUM
dpc-539	2	70	department	department	NOUN
dpc-539	2	71	of	of	ADP
dpc-539	2	72	cytopathology	cytopathology	NOUN
dpc-539	2	73	,	,	PUNCT
dpc-539	2	74	national	national	ADJ
dpc-539	2	75	and	and	CCONJ
dpc-539	2	76	kapodistrian	kapodistrian	ADJ
dpc-539	2	77	university	university	PROPN
dpc-539	2	78	of	of	ADP
dpc-539	2	79	athens	athens	PROPN
dpc-539	2	80	,	,	PUNCT
dpc-539	2	81	school	school	NOUN
dpc-539	2	82	of	of	ADP
dpc-539	2	83	medicine	medicine	NOUN
dpc-539	2	84	,	,	PUNCT
dpc-539	2	85	attikon	attikon	ADJ
dpc-539	2	86	university	university	NOUN
dpc-539	2	87	hospital	hospital	NOUN
dpc-539	2	88	,	,	PUNCT
dpc-539	2	89	athens	athens	PROPN
dpc-539	2	90	,	,	PUNCT
dpc-539	2	91	greece	greece	PROPN
dpc-539	2	92	key	key	ADJ
dpc-539	2	93	words	word	NOUN
dpc-539	2	94	:	:	PUNCT
dpc-539	2	95	malignant	malignant	ADJ
dpc-539	2	96	melanoma	melanoma	NOUN
dpc-539	2	97	,	,	PUNCT
dpc-539	2	98	histopathological	histopathological	ADJ
dpc-539	2	99	features	feature	NOUN
dpc-539	2	100	,	,	PUNCT
dpc-539	2	101	braf	braf	NOUN
dpc-539	2	102	mutations	mutation	NOUN
dpc-539	2	103	citation	citation	NOUN
dpc-539	2	104	:	:	PUNCT
dpc-539	2	105	spathis	spathis	PROPN
dpc-539	2	106	a	a	PROPN
dpc-539	2	107	,	,	PUNCT
dpc-539	2	108	katoulis	katoulis	PROPN
dpc-539	2	109	ac	ac	PROPN
dpc-539	2	110	,	,	PUNCT
dpc-539	2	111	damaskou	damaskou	PROPN
dpc-539	2	112	v	v	ADP
dpc-539	2	113	,	,	PUNCT
dpc-539	2	114	liakou	liakou	PROPN
dpc-539	2	115	ai	ai	NOUN
dpc-539	2	116	,	,	PUNCT
dpc-539	2	117	kottaridi	kottaridi	PROPN
dpc-539	2	118	c	c	NOUN
dpc-539	2	119	,	,	PUNCT
dpc-539	2	120	leventakou	leventakou	PROPN
dpc-539	2	121	d	d	PROPN
dpc-539	2	122	,	,	PUNCT
dpc-539	2	123	sgouros	sgouros	PROPN
dpc-539	2	124	d	d	PROPN
dpc-539	2	125	,	,	PUNCT
dpc-539	2	126	mamantopoulos	mamantopoulos	PROPN
dpc-539	2	127	a	a	NOUN
dpc-539	2	128	,	,	PUNCT
dpc-539	2	129	rigopoulos	rigopoulos	PROPN
dpc-539	2	130	d	d	PROPN
dpc-539	2	131	,	,	PUNCT
dpc-539	2	132	karakitsos	karakitsos	PROPN
dpc-539	2	133	p	p	NOUN
dpc-539	2	134	,	,	PUNCT
dpc-539	2	135	panayiotides	panayiotide	VERB
dpc-539	2	136	ig	ig	PRON
dpc-539	2	137	.	.	PUNCT
dpc-539	2	138	braf	braf	NOUN
dpc-539	2	139	mutation	mutation	NOUN
dpc-539	2	140	status	status	NOUN
dpc-539	2	141	in	in	ADP
dpc-539	2	142	primary	primary	ADJ
dpc-539	2	143	,	,	PUNCT
dpc-539	2	144	recurrent	recurrent	NOUN
dpc-539	2	145	,	,	PUNCT
dpc-539	2	146	and	and	CCONJ
dpc-539	2	147	metastatic	metastatic	ADJ
dpc-539	2	148	malignant	malignant	ADJ
dpc-539	2	149	melanoma	melanoma	NOUN
dpc-539	2	150	and	and	CCONJ
dpc-539	2	151	its	its	PRON
dpc-539	2	152	relation	relation	NOUN
dpc-539	2	153	to	to	ADP
dpc-539	2	154	histopathological	histopathological	ADJ
dpc-539	2	155	parameters	parameter	NOUN
dpc-539	2	156	.	.	PUNCT
dpc-539	3	1	dermatol	dermatol	NOUN
dpc-539	3	2	pract	pract	PROPN
dpc-539	3	3	concept	concept	NOUN
dpc-539	3	4	.	.	PUNCT
dpc-539	4	1	2019;9(1):54	2019;9(1):54	NUM
dpc-539	4	2	-	-	SYM
dpc-539	4	3	62	62	NUM
dpc-539	4	4	.	.	PUNCT
dpc-539	5	1	doi	doi	NOUN
dpc-539	5	2	:	:	PUNCT
dpc-539	5	3	https://doi.org/10.5826/dpc.0901a13	https://doi.org/10.5826/dpc.0901a13	NOUN
dpc-539	5	4	published	publish	VERB
dpc-539	5	5	:	:	PUNCT
dpc-539	5	6	january	january	PROPN
dpc-539	5	7	31	31	NUM
dpc-539	5	8	,	,	PUNCT
dpc-539	5	9	2019	2019	NUM
dpc-539	5	10	copyright	copyright	NOUN
dpc-539	5	11	:	:	PUNCT
dpc-539	5	12	©	©	PROPN
dpc-539	5	13	2019	2019	NUM
dpc-539	5	14	spathis	spathis	NOUN
dpc-539	5	15	et	et	PROPN
dpc-539	5	16	 	 	SPACE
dpc-539	5	17	al	al	PROPN
dpc-539	5	18	.	.	PUNCT
dpc-539	6	1	this	this	PRON
dpc-539	6	2	is	be	AUX
dpc-539	6	3	an	an	DET
dpc-539	6	4	open	open	ADJ
dpc-539	6	5	-	-	PUNCT
dpc-539	6	6	access	access	NOUN
dpc-539	6	7	article	article	NOUN
dpc-539	6	8	distributed	distribute	VERB
dpc-539	6	9	under	under	ADP
dpc-539	6	10	the	the	DET
dpc-539	6	11	terms	term	NOUN
dpc-539	6	12	of	of	ADP
dpc-539	6	13	the	the	DET
dpc-539	6	14	creative	creative	ADJ
dpc-539	6	15	commons	common	NOUN
dpc-539	6	16	attribution	attribution	NOUN
dpc-539	6	17	license	license	NOUN
dpc-539	6	18	,	,	PUNCT
dpc-539	6	19	which	which	PRON
dpc-539	6	20	permits	permit	VERB
dpc-539	6	21	unrestricted	unrestricted	ADJ
dpc-539	6	22	use	use	NOUN
dpc-539	6	23	,	,	PUNCT
dpc-539	6	24	distribution	distribution	NOUN
dpc-539	6	25	,	,	PUNCT
dpc-539	6	26	and	and	CCONJ
dpc-539	6	27	reproduction	reproduction	NOUN
dpc-539	6	28	in	in	ADP
dpc-539	6	29	any	any	DET
dpc-539	6	30	medium	medium	NOUN
dpc-539	6	31	,	,	PUNCT
dpc-539	6	32	provided	provide	VERB
dpc-539	6	33	the	the	DET
dpc-539	6	34	original	original	ADJ
dpc-539	6	35	author	author	NOUN
dpc-539	6	36	and	and	CCONJ
dpc-539	6	37	source	source	NOUN
dpc-539	6	38	are	be	AUX
dpc-539	6	39	credited	credit	VERB
dpc-539	6	40	.	.	PUNCT
dpc-539	7	1	funding	funding	NOUN
dpc-539	7	2	:	:	PUNCT
dpc-539	7	3	none	none	NOUN
dpc-539	7	4	.	.	PUNCT
dpc-539	8	1	competing	compete	VERB
dpc-539	8	2	interests	interest	NOUN
dpc-539	8	3	:	:	PUNCT
dpc-539	8	4	the	the	DET
dpc-539	8	5	authors	author	NOUN
dpc-539	8	6	have	have	VERB
dpc-539	8	7	no	no	DET
dpc-539	8	8	conflicts	conflict	NOUN
dpc-539	8	9	of	of	ADP
dpc-539	8	10	interest	interest	NOUN
dpc-539	8	11	to	to	PART
dpc-539	8	12	disclose	disclose	VERB
dpc-539	8	13	.	.	PUNCT
dpc-539	9	1	authorship	authorship	NOUN
dpc-539	9	2	:	:	PUNCT
dpc-539	9	3	the	the	DET
dpc-539	9	4	first	first	ADJ
dpc-539	9	5	3	3	NUM
dpc-539	9	6	authors	author	NOUN
dpc-539	9	7	contributed	contribute	VERB
dpc-539	9	8	equally	equally	ADV
dpc-539	9	9	to	to	ADP
dpc-539	9	10	this	this	DET
dpc-539	9	11	work	work	NOUN
dpc-539	9	12	.	.	PUNCT
dpc-539	10	1	all	all	DET
dpc-539	10	2	authors	author	NOUN
dpc-539	10	3	have	have	AUX
dpc-539	10	4	contributed	contribute	VERB
dpc-539	10	5	significantly	significantly	ADV
dpc-539	10	6	to	to	ADP
dpc-539	10	7	this	this	DET
dpc-539	10	8	publication	publication	NOUN
dpc-539	10	9	.	.	PUNCT
dpc-539	11	1	corresponding	correspond	VERB
dpc-539	11	2	author	author	NOUN
dpc-539	11	3	:	:	PUNCT
dpc-539	11	4	a.	a.	NOUN
dpc-539	11	5	spathis	spathis	PROPN
dpc-539	11	6	,	,	PUNCT
dpc-539	11	7	phd	phd	NOUN
dpc-539	11	8	,	,	PUNCT
dpc-539	11	9	scym(ascp)cm	scym(ascp)cm	PROPN
dpc-539	11	10	,	,	PUNCT
dpc-539	11	11	second	second	ADJ
dpc-539	11	12	department	department	NOUN
dpc-539	11	13	of	of	ADP
dpc-539	11	14	pathology	pathology	PROPN
dpc-539	11	15	,	,	PUNCT
dpc-539	11	16	national	national	ADJ
dpc-539	11	17	and	and	CCONJ
dpc-539	11	18	kapodistrian	kapodistrian	ADJ
dpc-539	11	19	university	university	PROPN
dpc-539	11	20	of	of	ADP
dpc-539	11	21	athens	athens	PROPN
dpc-539	11	22	,	,	PUNCT
dpc-539	11	23	attikon	attikon	ADJ
dpc-539	11	24	university	university	NOUN
dpc-539	11	25	hospital	hospital	NOUN
dpc-539	11	26	,	,	PUNCT
dpc-539	11	27	1	1	NUM
dpc-539	11	28	,	,	PUNCT
dpc-539	11	29	rimini	rimini	VERB
dpc-539	11	30	str	str	PROPN
dpc-539	11	31	.	.	PUNCT
dpc-539	11	32	,	,	PUNCT
dpc-539	11	33	gr-12462	gr-12462	PROPN
dpc-539	11	34	chaidari	chaidari	PROPN
dpc-539	11	35	,	,	PUNCT
dpc-539	11	36	athens	athens	PROPN
dpc-539	11	37	,	,	PUNCT
dpc-539	11	38	greece	greece	PROPN
dpc-539	11	39	.	.	PUNCT
dpc-539	11	40	email	email	NOUN
dpc-539	11	41	:	:	PUNCT
dpc-539	11	42	aspathis@med.uoa.gr	aspathis@med.uoa.gr	NOUN
dpc-539	11	43	background	background	NOUN
dpc-539	11	44	:	:	PUNCT
dpc-539	11	45	braf	braf	NOUN
dpc-539	11	46	mutations	mutation	NOUN
dpc-539	11	47	are	be	AUX
dpc-539	11	48	a	a	DET
dpc-539	11	49	common	common	ADJ
dpc-539	11	50	finding	finding	NOUN
dpc-539	11	51	in	in	ADP
dpc-539	11	52	malignant	malignant	ADJ
dpc-539	11	53	melanoma	melanoma	NOUN
dpc-539	11	54	(	(	PUNCT
dpc-539	11	55	mm	mm	NOUN
dpc-539	11	56	)	)	PUNCT
dpc-539	11	57	.	.	PUNCT
dpc-539	12	1	nevertheless	nevertheless	ADV
dpc-539	12	2	,	,	PUNCT
dpc-539	12	3	apart	apart	ADV
dpc-539	12	4	from	from	ADP
dpc-539	12	5	their	their	PRON
dpc-539	12	6	significance	significance	NOUN
dpc-539	12	7	as	as	ADP
dpc-539	12	8	a	a	DET
dpc-539	12	9	therapeutic	therapeutic	ADJ
dpc-539	12	10	target	target	NOUN
dpc-539	12	11	in	in	ADP
dpc-539	12	12	advanced	advanced	ADJ
dpc-539	12	13	melanoma	melanoma	NOUN
dpc-539	12	14	,	,	PUNCT
dpc-539	12	15	their	their	PRON
dpc-539	12	16	prognostic	prognostic	ADJ
dpc-539	12	17	value	value	NOUN
dpc-539	12	18	is	be	AUX
dpc-539	12	19	still	still	ADV
dpc-539	12	20	debated	debate	VERB
dpc-539	12	21	.	.	PUNCT
dpc-539	13	1	objective	objective	NOUN
dpc-539	13	2	:	:	PUNCT
dpc-539	13	3	to	to	PART
dpc-539	13	4	assess	assess	VERB
dpc-539	13	5	braf	braf	NOUN
dpc-539	13	6	mutation	mutation	NOUN
dpc-539	13	7	status	status	NOUN
dpc-539	13	8	in	in	ADP
dpc-539	13	9	primary	primary	ADJ
dpc-539	13	10	,	,	PUNCT
dpc-539	13	11	recurrent	recurrent	NOUN
dpc-539	13	12	,	,	PUNCT
dpc-539	13	13	or	or	CCONJ
dpc-539	13	14	metastatic	metastatic	ADJ
dpc-539	13	15	mm	mm	NOUN
dpc-539	13	16	and	and	CCONJ
dpc-539	13	17	its	its	PRON
dpc-539	13	18	correlations	correlation	NOUN
dpc-539	13	19	with	with	ADP
dpc-539	13	20	histopathological	histopathological	ADJ
dpc-539	13	21	findings	finding	NOUN
dpc-539	13	22	.	.	PUNCT
dpc-539	14	1	methods	method	NOUN
dpc-539	14	2	:	:	PUNCT
dpc-539	14	3	we	we	PRON
dpc-539	14	4	analyzed	analyze	VERB
dpc-539	14	5	203	203	NUM
dpc-539	14	6	samples	sample	NOUN
dpc-539	14	7	from	from	ADP
dpc-539	14	8	178	178	NUM
dpc-539	14	9	consecutive	consecutive	ADJ
dpc-539	14	10	patients	patient	NOUN
dpc-539	14	11	:	:	PUNCT
dpc-539	14	12	129	129	NUM
dpc-539	14	13	primary	primary	ADJ
dpc-539	14	14	cutaneous	cutaneous	ADJ
dpc-539	14	15	mm	mm	PROPN
dpc-539	14	16	,	,	PUNCT
dpc-539	14	17	49	49	NUM
dpc-539	14	18	metastatic	metastatic	ADJ
dpc-539	14	19	and	and	CCONJ
dpc-539	14	20	recurrent	recurrent	ADJ
dpc-539	14	21	mm	mm	NOUN
dpc-539	14	22	of	of	ADP
dpc-539	14	23	unknown	unknown	ADJ
dpc-539	14	24	primary	primary	ADJ
dpc-539	14	25	site	site	NOUN
dpc-539	14	26	,	,	PUNCT
dpc-539	14	27	and	and	CCONJ
dpc-539	14	28	25	25	NUM
dpc-539	14	29	cases	case	NOUN
dpc-539	14	30	of	of	ADP
dpc-539	14	31	recurrences	recurrence	NOUN
dpc-539	14	32	or	or	CCONJ
dpc-539	14	33	metastases	metastasis	NOUN
dpc-539	14	34	of	of	ADP
dpc-539	14	35	primary	primary	ADJ
dpc-539	14	36	mm	mm	PROPN
dpc-539	14	37	.	.	PUNCT
dpc-539	15	1	braf	braf	NOUN
dpc-539	15	2	mutations	mutation	NOUN
dpc-539	15	3	in	in	ADP
dpc-539	15	4	exon	exon	NOUN
dpc-539	15	5	15	15	NUM
dpc-539	15	6	were	be	AUX
dpc-539	15	7	identified	identify	VERB
dpc-539	15	8	with	with	ADP
dpc-539	15	9	real	real	ADJ
dpc-539	15	10	-	-	PUNCT
dpc-539	15	11	time	time	NOUN
dpc-539	15	12	polymerase	polymerase	NOUN
dpc-539	15	13	chain	chain	NOUN
dpc-539	15	14	reaction	reaction	NOUN
dpc-539	15	15	and/or	and/or	CCONJ
dpc-539	15	16	direct	direct	VERB
dpc-539	15	17	sequencing	sequencing	NOUN
dpc-539	15	18	or	or	CCONJ
dpc-539	15	19	pyrosequencing	pyrosequencing	NOUN
dpc-539	15	20	.	.	PUNCT
dpc-539	16	1	histopathological	histopathological	ADJ
dpc-539	16	2	examination	examination	NOUN
dpc-539	16	3	was	be	AUX
dpc-539	16	4	performed	perform	VERB
dpc-539	16	5	according	accord	VERB
dpc-539	16	6	to	to	ADP
dpc-539	16	7	standard	standard	ADJ
dpc-539	16	8	procedures	procedure	NOUN
dpc-539	16	9	.	.	PUNCT
dpc-539	17	1	results	result	NOUN
dpc-539	17	2	:	:	PUNCT
dpc-539	17	3	we	we	PRON
dpc-539	17	4	observed	observe	VERB
dpc-539	17	5	a	a	DET
dpc-539	17	6	42.1	42.1	NUM
dpc-539	17	7	%	%	NOUN
dpc-539	17	8	prevalence	prevalence	NOUN
dpc-539	17	9	of	of	ADP
dpc-539	17	10	braf	braf	NOUN
dpc-539	17	11	mutations	mutation	NOUN
dpc-539	17	12	at	at	ADP
dpc-539	17	13	codon	codon	NOUN
dpc-539	17	14	600	600	NUM
dpc-539	17	15	among	among	ADP
dpc-539	17	16	our	our	PRON
dpc-539	17	17	patients	patient	NOUN
dpc-539	17	18	,	,	PUNCT
dpc-539	17	19	84	84	NUM
dpc-539	17	20	%	%	NOUN
dpc-539	17	21	of	of	ADP
dpc-539	17	22	whom	whom	PRON
dpc-539	17	23	harbored	harbor	VERB
dpc-539	17	24	the	the	DET
dpc-539	17	25	v600e	v600e	PROPN
dpc-539	17	26	mutation	mutation	NOUN
dpc-539	17	27	.	.	PUNCT
dpc-539	18	1	mutations	mutation	NOUN
dpc-539	18	2	showed	show	VERB
dpc-539	18	3	a	a	DET
dpc-539	18	4	statistically	statistically	ADV
dpc-539	18	5	significant	significant	ADJ
dpc-539	18	6	increase	increase	NOUN
dpc-539	18	7	in	in	ADP
dpc-539	18	8	abstract	abstract	ADJ
dpc-539	18	9	research	research	NOUN
dpc-539	18	10	|	|	ADV
dpc-539	18	11	dermatol	dermatol	NOUN
dpc-539	18	12	pract	pract	NOUN
dpc-539	18	13	concept	concept	NOUN
dpc-539	18	14	2019;9(1):13	2019;9(1):13	NUM
dpc-539	18	15	55	55	NUM
dpc-539	18	16	topathological	topathological	ADJ
dpc-539	18	17	parameters	parameter	NOUN
dpc-539	18	18	associated	associate	VERB
dpc-539	18	19	with	with	ADP
dpc-539	18	20	prognosis	prognosis	NOUN
dpc-539	18	21	and	and	CCONJ
dpc-539	18	22	survival	survival	NOUN
dpc-539	18	23	of	of	ADP
dpc-539	18	24	mms	mms	NOUN
dpc-539	18	25	being	be	AUX
dpc-539	18	26	tumor	tumor	NOUN
dpc-539	18	27	thickness	thickness	NOUN
dpc-539	18	28	,	,	PUNCT
dpc-539	18	29	ulceration	ulceration	NOUN
dpc-539	18	30	,	,	PUNCT
dpc-539	18	31	and	and	CCONJ
dpc-539	18	32	,	,	PUNCT
dpc-539	18	33	more	more	ADV
dpc-539	18	34	recently	recently	ADV
dpc-539	18	35	,	,	PUNCT
dpc-539	18	36	mitotic	mitotic	ADJ
dpc-539	18	37	score	score	NOUN
dpc-539	18	38	at	at	ADP
dpc-539	18	39	primary	primary	ADJ
dpc-539	18	40	site	site	NOUN
dpc-539	18	41	[	[	X
dpc-539	18	42	10	10	NUM
dpc-539	18	43	]	]	PUNCT
dpc-539	18	44	.	.	PUNCT
dpc-539	19	1	we	we	PRON
dpc-539	19	2	assessed	assess	VERB
dpc-539	19	3	the	the	DET
dpc-539	19	4	braf	braf	NOUN
dpc-539	19	5	mutation	mutation	NOUN
dpc-539	19	6	status	status	NOUN
dpc-539	19	7	among	among	ADP
dpc-539	19	8	178	178	NUM
dpc-539	19	9	patients	patient	NOUN
dpc-539	19	10	with	with	ADP
dpc-539	19	11	primary	primary	ADJ
dpc-539	19	12	,	,	PUNCT
dpc-539	19	13	recurrent	recurrent	NOUN
dpc-539	19	14	,	,	PUNCT
dpc-539	19	15	or	or	CCONJ
dpc-539	19	16	metastatic	metastatic	ADJ
dpc-539	19	17	mm	mm	NOUN
dpc-539	19	18	.	.	PUNCT
dpc-539	20	1	our	our	PRON
dpc-539	20	2	aim	aim	NOUN
dpc-539	20	3	was	be	AUX
dpc-539	20	4	to	to	PART
dpc-539	20	5	study	study	VERB
dpc-539	20	6	the	the	DET
dpc-539	20	7	correlations	correlation	NOUN
dpc-539	20	8	between	between	ADP
dpc-539	20	9	histopathological	histopathological	ADJ
dpc-539	20	10	findings	finding	NOUN
dpc-539	20	11	in	in	ADP
dpc-539	20	12	primary	primary	ADJ
dpc-539	20	13	mm	mm	PROPN
dpc-539	20	14	and	and	CCONJ
dpc-539	20	15	the	the	DET
dpc-539	20	16	presence	presence	NOUN
dpc-539	20	17	of	of	ADP
dpc-539	20	18	mutated	mutate	VERB
dpc-539	20	19	braf	braf	NOUN
dpc-539	20	20	in	in	ADP
dpc-539	20	21	a	a	DET
dpc-539	20	22	greek	greek	ADJ
dpc-539	20	23	population	population	NOUN
dpc-539	20	24	.	.	PUNCT
dpc-539	21	1	methods	method	NOUN
dpc-539	21	2	specimens	specimen	VERB
dpc-539	21	3	a	a	DET
dpc-539	21	4	total	total	NOUN
dpc-539	21	5	of	of	ADP
dpc-539	21	6	203	203	NUM
dpc-539	21	7	consecutive	consecutive	ADJ
dpc-539	21	8	specimens	specimen	NOUN
dpc-539	21	9	from	from	ADP
dpc-539	21	10	178	178	NUM
dpc-539	21	11	patients	patient	NOUN
dpc-539	21	12	referred	refer	VERB
dpc-539	21	13	for	for	ADP
dpc-539	21	14	histopathological	histopathological	ADJ
dpc-539	21	15	examination	examination	NOUN
dpc-539	21	16	during	during	ADP
dpc-539	21	17	a	a	DET
dpc-539	21	18	12	12	NUM
dpc-539	21	19	-	-	PUNCT
dpc-539	21	20	year	year	NOUN
dpc-539	21	21	period	period	NOUN
dpc-539	21	22	(	(	PUNCT
dpc-539	21	23	2003	2003	NUM
dpc-539	21	24	-	-	SYM
dpc-539	21	25	2015	2015	NUM
dpc-539	21	26	)	)	PUNCT
dpc-539	21	27	were	be	AUX
dpc-539	21	28	analyzed	analyze	VERB
dpc-539	21	29	(	(	PUNCT
dpc-539	21	30	table	table	NOUN
dpc-539	21	31	1	1	NUM
dpc-539	21	32	)	)	PUNCT
dpc-539	21	33	.	.	PUNCT
dpc-539	22	1	these	these	PRON
dpc-539	22	2	included	include	VERB
dpc-539	22	3	129	129	NUM
dpc-539	22	4	primary	primary	ADJ
dpc-539	22	5	cutaneous	cutaneous	ADJ
dpc-539	22	6	mms	mms	NOUN
dpc-539	22	7	(	(	PUNCT
dpc-539	22	8	a	a	DET
dpc-539	22	9	primary	primary	ADJ
dpc-539	22	10	site	site	NOUN
dpc-539	22	11	recurrence	recurrence	NOUN
dpc-539	22	12	was	be	AUX
dpc-539	22	13	also	also	ADV
dpc-539	22	14	included	include	VERB
dpc-539	22	15	in	in	ADP
dpc-539	22	16	13	13	NUM
dpc-539	22	17	cases	case	NOUN
dpc-539	22	18	and	and	CCONJ
dpc-539	22	19	a	a	DET
dpc-539	22	20	metastasis	metastasis	NOUN
dpc-539	22	21	in	in	ADP
dpc-539	22	22	12	12	NUM
dpc-539	22	23	cases	case	NOUN
dpc-539	22	24	)	)	PUNCT
dpc-539	22	25	,	,	PUNCT
dpc-539	22	26	44	44	NUM
dpc-539	22	27	cases	case	NOUN
dpc-539	22	28	of	of	ADP
dpc-539	22	29	metastatic	metastatic	ADJ
dpc-539	22	30	mm	mm	NOUN
dpc-539	22	31	of	of	ADP
dpc-539	22	32	unknown	unknown	ADJ
dpc-539	22	33	primary	primary	ADJ
dpc-539	22	34	site	site	NOUN
dpc-539	22	35	,	,	PUNCT
dpc-539	22	36	and	and	CCONJ
dpc-539	22	37	5	5	NUM
dpc-539	22	38	cases	case	NOUN
dpc-539	22	39	of	of	ADP
dpc-539	22	40	cutaneous	cutaneous	ADJ
dpc-539	22	41	recurrence	recurrence	NOUN
dpc-539	22	42	without	without	ADP
dpc-539	22	43	an	an	DET
dpc-539	22	44	initial	initial	ADJ
dpc-539	22	45	tumor	tumor	NOUN
dpc-539	22	46	.	.	PUNCT
dpc-539	23	1	the	the	DET
dpc-539	23	2	institutional	institutional	ADJ
dpc-539	23	3	review	review	PROPN
dpc-539	23	4	board	board	NOUN
dpc-539	23	5	of	of	ADP
dpc-539	23	6	the	the	DET
dpc-539	23	7	hospital	hospital	NOUN
dpc-539	23	8	approved	approve	VERB
dpc-539	23	9	the	the	DET
dpc-539	23	10	study	study	NOUN
dpc-539	23	11	,	,	PUNCT
dpc-539	23	12	while	while	SCONJ
dpc-539	23	13	analysis	analysis	NOUN
dpc-539	23	14	was	be	AUX
dpc-539	23	15	performed	perform	VERB
dpc-539	23	16	on	on	ADP
dpc-539	23	17	anonymized	anonymize	VERB
dpc-539	23	18	data	datum	NOUN
dpc-539	23	19	.	.	PUNCT
dpc-539	24	1	all	all	DET
dpc-539	24	2	specimens	specimen	NOUN
dpc-539	24	3	were	be	AUX
dpc-539	24	4	fixed	fix	VERB
dpc-539	24	5	in	in	ADP
dpc-539	24	6	a	a	DET
dpc-539	24	7	buffered	buffer	VERB
dpc-539	24	8	10	10	NUM
dpc-539	24	9	%	%	NOUN
dpc-539	24	10	formalin	formalin	NOUN
dpc-539	24	11	solution	solution	NOUN
dpc-539	24	12	,	,	PUNCT
dpc-539	24	13	processed	process	VERB
dpc-539	24	14	according	accord	VERB
dpc-539	24	15	to	to	ADP
dpc-539	24	16	standard	standard	ADJ
dpc-539	24	17	protocols	protocol	NOUN
dpc-539	24	18	,	,	PUNCT
dpc-539	24	19	and	and	CCONJ
dpc-539	24	20	initially	initially	ADV
dpc-539	24	21	diagnosed	diagnose	VERB
dpc-539	24	22	by	by	ADP
dpc-539	24	23	the	the	DET
dpc-539	24	24	same	same	ADJ
dpc-539	24	25	experienced	experienced	ADJ
dpc-539	24	26	pathologist	pathologist	NOUN
dpc-539	24	27	.	.	PUNCT
dpc-539	25	1	another	another	DET
dpc-539	25	2	,	,	PUNCT
dpc-539	25	3	equally	equally	ADV
dpc-539	25	4	experienced	experienced	ADJ
dpc-539	25	5	pathologist	pathologist	NOUN
dpc-539	25	6	performed	perform	VERB
dpc-539	25	7	a	a	DET
dpc-539	25	8	second	second	ADJ
dpc-539	25	9	,	,	PUNCT
dpc-539	25	10	blind	blind	ADJ
dpc-539	25	11	evaluation	evaluation	NOUN
dpc-539	25	12	of	of	ADP
dpc-539	25	13	histopathological	histopathological	ADJ
dpc-539	25	14	diagnosis	diagnosis	NOUN
dpc-539	25	15	for	for	ADP
dpc-539	25	16	the	the	DET
dpc-539	25	17	purpose	purpose	NOUN
dpc-539	25	18	of	of	ADP
dpc-539	25	19	this	this	DET
dpc-539	25	20	study	study	NOUN
dpc-539	25	21	.	.	PUNCT
dpc-539	26	1	in	in	ADP
dpc-539	26	2	case	case	NOUN
dpc-539	26	3	of	of	ADP
dpc-539	26	4	disagreement	disagreement	NOUN
dpc-539	26	5	,	,	PUNCT
dpc-539	26	6	slides	slide	NOUN
dpc-539	26	7	were	be	AUX
dpc-539	26	8	conjointly	conjointly	ADV
dpc-539	26	9	rereviewed	rereviewe	VERB
dpc-539	26	10	.	.	PUNCT
dpc-539	27	1	braf	braf	NOUN
dpc-539	27	2	mutation	mutation	NOUN
dpc-539	27	3	analysis	analysis	NOUN
dpc-539	27	4	five	five	NUM
dpc-539	27	5	5-µm	5-µm	NUM
dpc-539	27	6	-	-	PUNCT
dpc-539	27	7	thick	thick	ADJ
dpc-539	27	8	sections	section	NOUN
dpc-539	27	9	were	be	AUX
dpc-539	27	10	obtained	obtain	VERB
dpc-539	27	11	from	from	ADP
dpc-539	27	12	a	a	DET
dpc-539	27	13	paraffin	paraffin	NOUN
dpc-539	27	14	block	block	NOUN
dpc-539	27	15	containing	contain	VERB
dpc-539	27	16	a	a	DET
dpc-539	27	17	representative	representative	ADJ
dpc-539	27	18	tumor	tumor	NOUN
dpc-539	27	19	area	area	NOUN
dpc-539	27	20	,	,	PUNCT
dpc-539	27	21	as	as	SCONJ
dpc-539	27	22	assessed	assess	VERB
dpc-539	27	23	in	in	ADP
dpc-539	27	24	a	a	DET
dpc-539	27	25	hematoxylin	hematoxylin	NOUN
dpc-539	27	26	and	and	CCONJ
dpc-539	27	27	eosin	eosin	NOUN
dpc-539	27	28	–	–	PUNCT
dpc-539	27	29	stained	stain	VERB
dpc-539	27	30	section	section	NOUN
dpc-539	27	31	.	.	PUNCT
dpc-539	28	1	dna	dna	PROPN
dpc-539	28	2	was	be	AUX
dpc-539	28	3	extracted	extract	VERB
dpc-539	28	4	with	with	ADP
dpc-539	28	5	purelink	purelink	PROPN
dpc-539	28	6	dna	dna	PROPN
dpc-539	28	7	mini	mini	NOUN
dpc-539	28	8	kit	kit	NOUN
dpc-539	28	9	(	(	PUNCT
dpc-539	28	10	invitrogen	invitrogen	PROPN
dpc-539	28	11	,	,	PUNCT
dpc-539	28	12	darmstadt	darmstadt	PROPN
dpc-539	28	13	,	,	PUNCT
dpc-539	28	14	germany	germany	PROPN
dpc-539	28	15	)	)	PUNCT
dpc-539	28	16	according	accord	VERB
dpc-539	28	17	to	to	ADP
dpc-539	28	18	the	the	DET
dpc-539	28	19	manufacturer	manufacturer	NOUN
dpc-539	28	20	’s	’s	PART
dpc-539	28	21	instructions	instruction	NOUN
dpc-539	28	22	.	.	PUNCT
dpc-539	29	1	detection	detection	NOUN
dpc-539	29	2	of	of	ADP
dpc-539	29	3	braf	braf	NOUN
dpc-539	29	4	p.v600e	p.v600e	NOUN
dpc-539	29	5	mutation	mutation	NOUN
dpc-539	29	6	was	be	AUX
dpc-539	29	7	performed	perform	VERB
dpc-539	29	8	with	with	ADP
dpc-539	29	9	the	the	DET
dpc-539	29	10	use	use	NOUN
dpc-539	29	11	of	of	ADP
dpc-539	29	12	2	2	NUM
dpc-539	29	13	molecular	molecular	ADJ
dpc-539	29	14	beacons	beacon	NOUN
dpc-539	29	15	in	in	ADP
dpc-539	29	16	a	a	DET
dpc-539	29	17	real	real	ADJ
dpc-539	29	18	-	-	PUNCT
dpc-539	29	19	time	time	NOUN
dpc-539	29	20	polymerase	polymerase	NOUN
dpc-539	29	21	chain	chain	NOUN
dpc-539	29	22	reaction	reaction	NOUN
dpc-539	29	23	as	as	SCONJ
dpc-539	29	24	previously	previously	ADV
dpc-539	29	25	described	describe	VERB
dpc-539	29	26	[	[	X
dpc-539	29	27	11	11	NUM
dpc-539	29	28	]	]	PUNCT
dpc-539	29	29	.	.	PUNCT
dpc-539	30	1	all	all	DET
dpc-539	30	2	wild	wild	ADJ
dpc-539	30	3	-	-	PUNCT
dpc-539	30	4	type	type	NOUN
dpc-539	30	5	and	and	CCONJ
dpc-539	30	6	selected	select	VERB
dpc-539	30	7	mutated	mutate	VERB
dpc-539	30	8	samples	sample	NOUN
dpc-539	30	9	were	be	AUX
dpc-539	30	10	sent	send	VERB
dpc-539	30	11	for	for	ADP
dpc-539	30	12	verification	verification	NOUN
dpc-539	30	13	with	with	ADP
dpc-539	30	14	direct	direct	ADJ
dpc-539	30	15	sequencing	sequencing	NOUN
dpc-539	30	16	of	of	ADP
dpc-539	30	17	exon	exon	NOUN
dpc-539	30	18	15	15	NUM
dpc-539	30	19	of	of	ADP
dpc-539	30	20	braf	braf	NOUN
dpc-539	30	21	using	use	VERB
dpc-539	30	22	previously	previously	ADV
dpc-539	30	23	published	publish	VERB
dpc-539	30	24	primers	primer	NOUN
dpc-539	30	25	or	or	CCONJ
dpc-539	30	26	were	be	AUX
dpc-539	30	27	introduction	introduction	NOUN
dpc-539	30	28	malignant	malignant	ADJ
dpc-539	30	29	melanoma	melanoma	NOUN
dpc-539	30	30	(	(	PUNCT
dpc-539	30	31	mm	mm	NOUN
dpc-539	30	32	)	)	PUNCT
dpc-539	30	33	is	be	AUX
dpc-539	30	34	one	one	NUM
dpc-539	30	35	of	of	ADP
dpc-539	30	36	the	the	DET
dpc-539	30	37	most	most	ADV
dpc-539	30	38	common	common	ADJ
dpc-539	30	39	types	type	NOUN
dpc-539	30	40	of	of	ADP
dpc-539	30	41	cancer	cancer	NOUN
dpc-539	30	42	in	in	ADP
dpc-539	30	43	humans	human	NOUN
dpc-539	30	44	,	,	PUNCT
dpc-539	30	45	being	be	AUX
dpc-539	30	46	the	the	DET
dpc-539	30	47	fifth	fifth	ADJ
dpc-539	30	48	most	most	ADV
dpc-539	30	49	common	common	ADJ
dpc-539	30	50	in	in	ADP
dpc-539	30	51	men	man	NOUN
dpc-539	30	52	and	and	CCONJ
dpc-539	30	53	the	the	DET
dpc-539	30	54	sixth	sixth	ADJ
dpc-539	30	55	in	in	ADP
dpc-539	30	56	women	woman	NOUN
dpc-539	30	57	in	in	ADP
dpc-539	30	58	the	the	DET
dpc-539	30	59	united	united	PROPN
dpc-539	30	60	states	states	PROPN
dpc-539	31	1	[	[	X
dpc-539	31	2	1	1	NUM
dpc-539	31	3	]	]	PUNCT
dpc-539	31	4	.	.	PUNCT
dpc-539	32	1	although	although	SCONJ
dpc-539	32	2	mm	mm	PROPN
dpc-539	32	3	represents	represent	VERB
dpc-539	32	4	less	less	ADJ
dpc-539	32	5	than	than	ADP
dpc-539	32	6	2	2	NUM
dpc-539	32	7	%	%	NOUN
dpc-539	32	8	of	of	ADP
dpc-539	32	9	skin	skin	NOUN
dpc-539	32	10	cancer	cancer	NOUN
dpc-539	32	11	,	,	PUNCT
dpc-539	32	12	it	it	PRON
dpc-539	32	13	accounts	account	VERB
dpc-539	32	14	for	for	ADP
dpc-539	32	15	the	the	DET
dpc-539	32	16	vast	vast	ADJ
dpc-539	32	17	majority	majority	NOUN
dpc-539	32	18	of	of	ADP
dpc-539	32	19	deaths	death	NOUN
dpc-539	32	20	,	,	PUNCT
dpc-539	32	21	with	with	ADP
dpc-539	32	22	increasing	increase	VERB
dpc-539	32	23	incidence	incidence	NOUN
dpc-539	32	24	worldwide	worldwide	ADV
dpc-539	32	25	[	[	X
dpc-539	32	26	1	1	NUM
dpc-539	32	27	]	]	PUNCT
dpc-539	32	28	.	.	PUNCT
dpc-539	33	1	the	the	DET
dpc-539	33	2	underlying	underlie	VERB
dpc-539	33	3	etiopathogenetic	etiopathogenetic	ADJ
dpc-539	33	4	mechanisms	mechanism	NOUN
dpc-539	33	5	remain	remain	VERB
dpc-539	33	6	so	so	ADV
dpc-539	33	7	far	far	ADV
dpc-539	33	8	largely	largely	ADV
dpc-539	33	9	unknown	unknown	ADJ
dpc-539	33	10	.	.	PUNCT
dpc-539	34	1	following	follow	VERB
dpc-539	34	2	discovery	discovery	NOUN
dpc-539	34	3	of	of	ADP
dpc-539	34	4	braf	braf	NOUN
dpc-539	34	5	oncogenic	oncogenic	ADJ
dpc-539	34	6	mutations	mutation	NOUN
dpc-539	34	7	in	in	ADP
dpc-539	34	8	various	various	ADJ
dpc-539	34	9	types	type	NOUN
dpc-539	34	10	of	of	ADP
dpc-539	34	11	malignancies	malignancy	NOUN
dpc-539	34	12	,	,	PUNCT
dpc-539	34	13	a	a	DET
dpc-539	34	14	significant	significant	ADJ
dpc-539	34	15	pathogenetic	pathogenetic	ADJ
dpc-539	34	16	role	role	NOUN
dpc-539	34	17	for	for	ADP
dpc-539	34	18	mutated	mutate	VERB
dpc-539	34	19	braf	braf	NOUN
dpc-539	34	20	has	have	AUX
dpc-539	34	21	been	be	AUX
dpc-539	34	22	proposed	propose	VERB
dpc-539	34	23	for	for	ADP
dpc-539	34	24	mm	mm	PROPN
dpc-539	35	1	[	[	X
dpc-539	35	2	2	2	NUM
dpc-539	35	3	]	]	PUNCT
dpc-539	35	4	.	.	PUNCT
dpc-539	36	1	to	to	ADP
dpc-539	36	2	date	date	NOUN
dpc-539	36	3	,	,	PUNCT
dpc-539	36	4	more	more	ADJ
dpc-539	36	5	than	than	ADP
dpc-539	36	6	30	30	NUM
dpc-539	36	7	different	different	ADJ
dpc-539	36	8	mutations	mutation	NOUN
dpc-539	36	9	in	in	ADP
dpc-539	36	10	the	the	DET
dpc-539	36	11	braf	braf	NOUN
dpc-539	36	12	gene	gene	NOUN
dpc-539	36	13	have	have	AUX
dpc-539	36	14	been	be	AUX
dpc-539	36	15	identified	identify	VERB
dpc-539	36	16	.	.	PUNCT
dpc-539	37	1	the	the	DET
dpc-539	37	2	most	most	ADV
dpc-539	37	3	frequent	frequent	ADJ
dpc-539	37	4	,	,	PUNCT
dpc-539	37	5	accounting	account	VERB
dpc-539	37	6	for	for	ADP
dpc-539	37	7	almost	almost	ADV
dpc-539	37	8	90	90	NUM
dpc-539	37	9	%	%	NOUN
dpc-539	37	10	,	,	PUNCT
dpc-539	37	11	concerns	concern	NOUN
dpc-539	37	12	substitution	substitution	NOUN
dpc-539	37	13	of	of	ADP
dpc-539	37	14	thymine	thymine	NOUN
dpc-539	37	15	by	by	ADP
dpc-539	37	16	adenine	adenine	NOUN
dpc-539	37	17	at	at	ADP
dpc-539	37	18	nucleotide	nucleotide	NOUN
dpc-539	37	19	c.1799	c.1799	PROPN
dpc-539	37	20	,	,	PUNCT
dpc-539	37	21	leading	lead	VERB
dpc-539	37	22	to	to	ADP
dpc-539	37	23	valine	valine	NOUN
dpc-539	37	24	(	(	PUNCT
dpc-539	37	25	v	v	NOUN
dpc-539	37	26	)	)	PUNCT
dpc-539	37	27	being	be	AUX
dpc-539	37	28	substituted	substitute	VERB
dpc-539	37	29	by	by	ADP
dpc-539	37	30	glutamate	glutamate	NOUN
dpc-539	37	31	(	(	PUNCT
dpc-539	37	32	e	e	NOUN
dpc-539	37	33	)	)	PUNCT
dpc-539	37	34	at	at	ADP
dpc-539	37	35	codon	codon	NOUN
dpc-539	37	36	600	600	NUM
dpc-539	37	37	(	(	PUNCT
dpc-539	37	38	p.v600e	p.v600e	NOUN
dpc-539	37	39	)	)	PUNCT
dpc-539	37	40	in	in	ADP
dpc-539	37	41	the	the	DET
dpc-539	37	42	activation	activation	NOUN
dpc-539	37	43	segment	segment	NOUN
dpc-539	37	44	of	of	ADP
dpc-539	37	45	the	the	DET
dpc-539	37	46	gene	gene	NOUN
dpc-539	37	47	promoting	promote	VERB
dpc-539	37	48	cell	cell	NOUN
dpc-539	37	49	survival	survival	NOUN
dpc-539	37	50	via	via	ADP
dpc-539	37	51	the	the	DET
dpc-539	37	52	erk	erk	PROPN
dpc-539	37	53	or	or	CCONJ
dpc-539	37	54	mek	mek	PROPN
dpc-539	37	55	signaling	signal	VERB
dpc-539	37	56	cascade	cascade	NOUN
dpc-539	38	1	[	[	X
dpc-539	38	2	3	3	NUM
dpc-539	38	3	]	]	PUNCT
dpc-539	38	4	.	.	PUNCT
dpc-539	39	1	frequency	frequency	NOUN
dpc-539	39	2	of	of	ADP
dpc-539	39	3	braf	braf	NOUN
dpc-539	39	4	mutations	mutation	NOUN
dpc-539	39	5	varies	vary	VERB
dpc-539	39	6	widely	widely	ADV
dpc-539	39	7	,	,	PUNCT
dpc-539	39	8	from	from	ADP
dpc-539	39	9	more	more	ADJ
dpc-539	39	10	than	than	ADP
dpc-539	39	11	80	80	NUM
dpc-539	39	12	%	%	NOUN
dpc-539	39	13	in	in	ADP
dpc-539	39	14	melanomas	melanomas	NOUN
dpc-539	39	15	and	and	CCONJ
dpc-539	39	16	nevi	nevi	PROPN
dpc-539	39	17	,	,	PUNCT
dpc-539	39	18	to	to	ADP
dpc-539	39	19	1%-3	1%-3	NUM
dpc-539	39	20	%	%	NOUN
dpc-539	39	21	in	in	ADP
dpc-539	39	22	lung	lung	NOUN
dpc-539	39	23	and	and	CCONJ
dpc-539	39	24	5	5	NUM
dpc-539	39	25	%	%	NOUN
dpc-539	39	26	in	in	ADP
dpc-539	39	27	colorectal	colorectal	ADJ
dpc-539	39	28	carcinoma	carcinoma	NOUN
dpc-539	39	29	[	[	X
dpc-539	39	30	2	2	NUM
dpc-539	39	31	]	]	PUNCT
dpc-539	39	32	.	.	PUNCT
dpc-539	40	1	of	of	ADP
dpc-539	40	2	note	note	NOUN
dpc-539	40	3	,	,	PUNCT
dpc-539	40	4	braf	braf	NOUN
dpc-539	40	5	mutations	mutation	NOUN
dpc-539	40	6	are	be	AUX
dpc-539	40	7	not	not	PART
dpc-539	40	8	exclusive	exclusive	ADJ
dpc-539	40	9	to	to	ADP
dpc-539	40	10	mm	mm	PROPN
dpc-539	40	11	,	,	PUNCT
dpc-539	40	12	having	having	AUX
dpc-539	40	13	also	also	ADV
dpc-539	40	14	been	be	AUX
dpc-539	40	15	found	find	VERB
dpc-539	40	16	in	in	ADP
dpc-539	40	17	up	up	ADP
dpc-539	40	18	to	to	PART
dpc-539	40	19	80	80	NUM
dpc-539	40	20	%	%	NOUN
dpc-539	40	21	of	of	ADP
dpc-539	40	22	benign	benign	ADJ
dpc-539	40	23	melanocytic	melanocytic	ADJ
dpc-539	40	24	lesions	lesion	NOUN
dpc-539	40	25	,	,	PUNCT
dpc-539	40	26	albeit	albeit	SCONJ
dpc-539	40	27	in	in	ADP
dpc-539	40	28	limited	limited	ADJ
dpc-539	40	29	study	study	NOUN
dpc-539	40	30	populations	population	NOUN
dpc-539	40	31	[	[	X
dpc-539	40	32	4	4	NUM
dpc-539	40	33	]	]	PUNCT
dpc-539	40	34	.	.	PUNCT
dpc-539	41	1	oncogenic	oncogenic	ADJ
dpc-539	41	2	mutations	mutation	NOUN
dpc-539	41	3	of	of	ADP
dpc-539	41	4	braf	braf	NOUN
dpc-539	41	5	are	be	AUX
dpc-539	41	6	mimicking	mimic	VERB
dpc-539	41	7	a	a	DET
dpc-539	41	8	constantly	constantly	ADV
dpc-539	41	9	activated	activate	VERB
dpc-539	41	10	state	state	NOUN
dpc-539	41	11	,	,	PUNCT
dpc-539	41	12	resulting	result	VERB
dpc-539	41	13	in	in	ADP
dpc-539	41	14	uncontrolled	uncontrolled	ADJ
dpc-539	41	15	cell	cell	NOUN
dpc-539	41	16	growth	growth	NOUN
dpc-539	41	17	and	and	CCONJ
dpc-539	41	18	proliferation	proliferation	NOUN
dpc-539	41	19	.	.	PUNCT
dpc-539	42	1	more	more	ADV
dpc-539	42	2	recently	recently	ADV
dpc-539	42	3	,	,	PUNCT
dpc-539	42	4	oncogenic	oncogenic	ADJ
dpc-539	42	5	braf	braf	NOUN
dpc-539	42	6	mutations	mutation	NOUN
dpc-539	42	7	have	have	AUX
dpc-539	42	8	been	be	AUX
dpc-539	42	9	connected	connect	VERB
dpc-539	42	10	to	to	ADP
dpc-539	42	11	up	up	ADV
dpc-539	42	12	-	-	PUNCT
dpc-539	42	13	regulated	regulate	VERB
dpc-539	42	14	cell	cell	NOUN
dpc-539	42	15	proliferation	proliferation	NOUN
dpc-539	42	16	and	and	CCONJ
dpc-539	42	17	invasion	invasion	NOUN
dpc-539	42	18	ability	ability	NOUN
dpc-539	42	19	[	[	X
dpc-539	42	20	5	5	NUM
dpc-539	42	21	]	]	PUNCT
dpc-539	42	22	.	.	PUNCT
dpc-539	43	1	it	it	PRON
dpc-539	43	2	has	have	AUX
dpc-539	43	3	been	be	AUX
dpc-539	43	4	suggested	suggest	VERB
dpc-539	43	5	that	that	SCONJ
dpc-539	43	6	braf	braf	NOUN
dpc-539	43	7	mutations	mutation	NOUN
dpc-539	43	8	may	may	AUX
dpc-539	43	9	constitute	constitute	VERB
dpc-539	43	10	a	a	DET
dpc-539	43	11	tumor	tumor	NOUN
dpc-539	43	12	progression	progression	NOUN
dpc-539	43	13	event	event	NOUN
dpc-539	43	14	rather	rather	ADV
dpc-539	43	15	than	than	ADP
dpc-539	43	16	an	an	DET
dpc-539	43	17	initiating	initiate	VERB
dpc-539	43	18	event	event	NOUN
dpc-539	43	19	in	in	ADP
dpc-539	43	20	mm	mm	PROPN
dpc-539	43	21	tumorigenesis	tumorigenesis	NOUN
dpc-539	43	22	,	,	PUNCT
dpc-539	43	23	and	and	CCONJ
dpc-539	43	24	that	that	SCONJ
dpc-539	43	25	other	other	ADJ
dpc-539	43	26	genetic	genetic	ADJ
dpc-539	43	27	or	or	CCONJ
dpc-539	43	28	epigenetic	epigenetic	ADJ
dpc-539	43	29	factors	factor	NOUN
dpc-539	43	30	are	be	AUX
dpc-539	43	31	also	also	ADV
dpc-539	43	32	involved	involve	VERB
dpc-539	43	33	[	[	PUNCT
dpc-539	43	34	6	6	NUM
dpc-539	43	35	,	,	PUNCT
dpc-539	43	36	7	7	NUM
dpc-539	43	37	]	]	PUNCT
dpc-539	43	38	.	.	PUNCT
dpc-539	44	1	the	the	DET
dpc-539	44	2	presence	presence	NOUN
dpc-539	44	3	of	of	ADP
dpc-539	44	4	a	a	DET
dpc-539	44	5	braf	braf	NOUN
dpc-539	44	6	mutation	mutation	NOUN
dpc-539	44	7	in	in	ADP
dpc-539	44	8	primary	primary	ADJ
dpc-539	44	9	mm	mm	PROPN
dpc-539	44	10	of	of	ADP
dpc-539	44	11	stage	stage	NOUN
dpc-539	44	12	iii	iii	NOUN
dpc-539	44	13	has	have	AUX
dpc-539	44	14	been	be	AUX
dpc-539	44	15	associated	associate	VERB
dpc-539	44	16	with	with	ADP
dpc-539	44	17	worse	bad	ADJ
dpc-539	44	18	prognosis	prognosis	NOUN
dpc-539	44	19	and	and	CCONJ
dpc-539	44	20	also	also	ADV
dpc-539	44	21	seems	seem	VERB
dpc-539	44	22	to	to	PART
dpc-539	44	23	be	be	AUX
dpc-539	44	24	related	relate	VERB
dpc-539	44	25	to	to	ADP
dpc-539	44	26	progression	progression	NOUN
dpc-539	44	27	-	-	PUNCT
dpc-539	44	28	free	free	ADJ
dpc-539	44	29	interval	interval	NOUN
dpc-539	44	30	and	and	CCONJ
dpc-539	44	31	overall	overall	ADJ
dpc-539	44	32	survival	survival	NOUN
dpc-539	45	1	[	[	X
dpc-539	45	2	8	8	NUM
dpc-539	45	3	]	]	PUNCT
dpc-539	45	4	.	.	PUNCT
dpc-539	46	1	mutated	mutate	VERB
dpc-539	46	2	braf	braf	NOUN
dpc-539	46	3	constitutes	constitute	VERB
dpc-539	46	4	a	a	DET
dpc-539	46	5	therapeutic	therapeutic	ADJ
dpc-539	46	6	target	target	NOUN
dpc-539	46	7	for	for	ADP
dpc-539	46	8	patients	patient	NOUN
dpc-539	46	9	with	with	ADP
dpc-539	46	10	advanced	advanced	ADJ
dpc-539	46	11	mms	mms	NOUN
dpc-539	46	12	.	.	PUNCT
dpc-539	47	1	different	different	ADJ
dpc-539	47	2	braf	braf	NOUN
dpc-539	47	3	inhibitors	inhibitor	NOUN
dpc-539	47	4	have	have	AUX
dpc-539	47	5	been	be	AUX
dpc-539	47	6	tested	test	VERB
dpc-539	47	7	,	,	PUNCT
dpc-539	47	8	with	with	ADP
dpc-539	47	9	significant	significant	ADJ
dpc-539	47	10	benefits	benefit	NOUN
dpc-539	47	11	in	in	ADP
dpc-539	47	12	terms	term	NOUN
dpc-539	47	13	of	of	ADP
dpc-539	47	14	increased	increase	VERB
dpc-539	47	15	response	response	NOUN
dpc-539	47	16	rate	rate	NOUN
dpc-539	47	17	,	,	PUNCT
dpc-539	47	18	progression	progression	NOUN
dpc-539	47	19	-	-	PUNCT
dpc-539	47	20	free	free	ADJ
dpc-539	47	21	survival	survival	NOUN
dpc-539	47	22	,	,	PUNCT
dpc-539	47	23	and	and	CCONJ
dpc-539	47	24	overall	overall	ADJ
dpc-539	47	25	survival	survival	NOUN
dpc-539	48	1	[	[	X
dpc-539	48	2	9	9	NUM
dpc-539	48	3	]	]	PUNCT
dpc-539	48	4	.	.	PUNCT
dpc-539	49	1	nevertheless	nevertheless	ADV
dpc-539	49	2	,	,	PUNCT
dpc-539	49	3	the	the	DET
dpc-539	49	4	prognostic	prognostic	ADJ
dpc-539	49	5	value	value	NOUN
dpc-539	49	6	of	of	ADP
dpc-539	49	7	braf	braf	NOUN
dpc-539	49	8	mutations	mutation	NOUN
dpc-539	49	9	has	have	AUX
dpc-539	49	10	not	not	PART
dpc-539	49	11	been	be	AUX
dpc-539	49	12	fully	fully	ADV
dpc-539	49	13	assessed	assess	VERB
dpc-539	49	14	,	,	PUNCT
dpc-539	49	15	with	with	ADP
dpc-539	49	16	the	the	DET
dpc-539	49	17	only	only	ADJ
dpc-539	49	18	established	establish	VERB
dpc-539	49	19	hisyounger	hisyounger	NOUN
dpc-539	49	20	patients	patient	NOUN
dpc-539	49	21	(	(	PUNCT
dpc-539	49	22	p	p	X
dpc-539	49	23	=	=	NOUN
dpc-539	49	24	0.011	0.011	NUM
dpc-539	49	25	)	)	PUNCT
dpc-539	49	26	,	,	PUNCT
dpc-539	49	27	in	in	ADP
dpc-539	49	28	ulcerated	ulcerated	ADJ
dpc-539	49	29	tumors	tumor	NOUN
dpc-539	49	30	(	(	PUNCT
dpc-539	49	31	p	p	X
dpc-539	49	32	=	=	NOUN
dpc-539	49	33	0.020	0.020	NUM
dpc-539	49	34	)	)	PUNCT
dpc-539	49	35	,	,	PUNCT
dpc-539	49	36	and	and	CCONJ
dpc-539	49	37	in	in	ADP
dpc-539	49	38	tumors	tumor	NOUN
dpc-539	49	39	lacking	lack	VERB
dpc-539	49	40	solar	solar	ADJ
dpc-539	49	41	elastosis	elastosis	NOUN
dpc-539	49	42	in	in	ADP
dpc-539	49	43	adjacent	adjacent	ADJ
dpc-539	49	44	dermis	dermis	NOUN
dpc-539	49	45	(	(	PUNCT
dpc-539	49	46	p	p	NOUN
dpc-539	49	47	=	=	NOUN
dpc-539	49	48	0.008	0.008	NUM
dpc-539	49	49	)	)	PUNCT
dpc-539	49	50	.	.	PUNCT
dpc-539	50	1	mutations	mutation	NOUN
dpc-539	50	2	were	be	AUX
dpc-539	50	3	also	also	ADV
dpc-539	50	4	more	more	ADV
dpc-539	50	5	common	common	ADJ
dpc-539	50	6	in	in	ADP
dpc-539	50	7	male	male	ADJ
dpc-539	50	8	patients	patient	NOUN
dpc-539	50	9	,	,	PUNCT
dpc-539	50	10	as	as	ADV
dpc-539	50	11	well	well	ADV
dpc-539	50	12	as	as	ADP
dpc-539	50	13	in	in	ADP
dpc-539	50	14	primary	primary	ADJ
dpc-539	50	15	mms	mms	NOUN
dpc-539	50	16	of	of	ADP
dpc-539	50	17	the	the	DET
dpc-539	50	18	torso	torso	NOUN
dpc-539	50	19	,	,	PUNCT
dpc-539	50	20	and	and	CCONJ
dpc-539	50	21	in	in	ADP
dpc-539	50	22	nonvisceral	nonvisceral	ADJ
dpc-539	50	23	metastases	metastasis	NOUN
dpc-539	50	24	,	,	PUNCT
dpc-539	50	25	however	however	ADV
dpc-539	50	26	without	without	ADP
dpc-539	50	27	reaching	reach	VERB
dpc-539	50	28	statistical	statistical	ADJ
dpc-539	50	29	significance	significance	NOUN
dpc-539	50	30	.	.	PUNCT
dpc-539	51	1	logistic	logistic	ADJ
dpc-539	51	2	regression	regression	NOUN
dpc-539	51	3	analysis	analysis	NOUN
dpc-539	51	4	identified	identify	VERB
dpc-539	51	5	type	type	NOUN
dpc-539	51	6	and	and	CCONJ
dpc-539	51	7	ulceration	ulceration	NOUN
dpc-539	51	8	as	as	ADP
dpc-539	51	9	the	the	DET
dpc-539	51	10	only	only	ADJ
dpc-539	51	11	significant	significant	ADJ
dpc-539	51	12	predictors	predictor	NOUN
dpc-539	51	13	of	of	ADP
dpc-539	51	14	braf	braf	NOUN
dpc-539	51	15	mutation	mutation	NOUN
dpc-539	51	16	.	.	PUNCT
dpc-539	52	1	the	the	DET
dpc-539	52	2	highest	high	ADJ
dpc-539	52	3	frequencies	frequency	NOUN
dpc-539	52	4	of	of	ADP
dpc-539	52	5	mutated	mutate	VERB
dpc-539	52	6	braf	braf	NOUN
dpc-539	52	7	were	be	AUX
dpc-539	52	8	identified	identify	VERB
dpc-539	52	9	in	in	ADP
dpc-539	52	10	superficial	superficial	ADJ
dpc-539	52	11	spreading	spread	VERB
dpc-539	52	12	and	and	CCONJ
dpc-539	52	13	nodular	nodular	ADJ
dpc-539	52	14	types	type	NOUN
dpc-539	52	15	,	,	PUNCT
dpc-539	52	16	and	and	CCONJ
dpc-539	52	17	the	the	DET
dpc-539	52	18	lowest	low	ADJ
dpc-539	52	19	in	in	ADP
dpc-539	52	20	acral	acral	ADJ
dpc-539	52	21	lentiginous	lentiginous	ADJ
dpc-539	52	22	and	and	CCONJ
dpc-539	52	23	lentigo	lentigo	ADJ
dpc-539	52	24	maligna	maligna	NOUN
dpc-539	52	25	types	type	NOUN
dpc-539	52	26	.	.	PUNCT
dpc-539	53	1	in	in	ADP
dpc-539	53	2	situ	situ	ADJ
dpc-539	53	3	mm	mm	NOUN
dpc-539	53	4	and	and	CCONJ
dpc-539	53	5	primary	primary	ADJ
dpc-539	53	6	dermal	dermal	NOUN
dpc-539	53	7	melanoma	melanoma	NOUN
dpc-539	53	8	displayed	display	VERB
dpc-539	53	9	intermediate	intermediate	ADJ
dpc-539	53	10	frequencies	frequency	NOUN
dpc-539	53	11	.	.	PUNCT
dpc-539	54	1	conclusion	conclusion	NOUN
dpc-539	54	2	:	:	PUNCT
dpc-539	54	3	frequency	frequency	NOUN
dpc-539	54	4	of	of	ADP
dpc-539	54	5	mutated	mutate	VERB
dpc-539	54	6	braf	braf	NOUN
dpc-539	54	7	is	be	AUX
dpc-539	54	8	type	type	NOUN
dpc-539	54	9	-	-	PUNCT
dpc-539	54	10	related	relate	VERB
dpc-539	54	11	and	and	CCONJ
dpc-539	54	12	correlated	correlate	VERB
dpc-539	54	13	with	with	ADP
dpc-539	54	14	ulceration	ulceration	NOUN
dpc-539	54	15	,	,	PUNCT
dpc-539	54	16	a	a	DET
dpc-539	54	17	known	know	VERB
dpc-539	54	18	adverse	adverse	ADJ
dpc-539	54	19	prognostic	prognostic	ADJ
dpc-539	54	20	factor	factor	NOUN
dpc-539	54	21	.	.	PUNCT
dpc-539	55	1	abstract	abstract	ADJ
dpc-539	55	2	56	56	NUM
dpc-539	55	3	research	research	NOUN
dpc-539	55	4	|	|	ADV
dpc-539	55	5	dermatol	dermatol	NOUN
dpc-539	55	6	pract	pract	NOUN
dpc-539	55	7	concept	concept	NOUN
dpc-539	55	8	2019;9(1):13	2019;9(1):13	NUM
dpc-539	55	9	an	an	DET
dpc-539	55	10	average	average	NOUN
dpc-539	55	11	of	of	ADP
dpc-539	55	12	70	70	NUM
dpc-539	55	13	months	month	NOUN
dpc-539	55	14	(	(	PUNCT
dpc-539	55	15	range	range	NOUN
dpc-539	55	16	1	1	NUM
dpc-539	55	17	-	-	SYM
dpc-539	55	18	162	162	NUM
dpc-539	55	19	months	month	NOUN
dpc-539	55	20	)	)	PUNCT
dpc-539	55	21	.	.	PUNCT
dpc-539	56	1	recurrent	recurrent	ADJ
dpc-539	56	2	samples	sample	NOUN
dpc-539	56	3	were	be	AUX
dpc-539	56	4	received	receive	VERB
dpc-539	56	5	within	within	ADP
dpc-539	56	6	1	1	NUM
dpc-539	56	7	to	to	PART
dpc-539	56	8	32	32	NUM
dpc-539	56	9	months	month	NOUN
dpc-539	56	10	(	(	PUNCT
dpc-539	56	11	mean	mean	NOUN
dpc-539	56	12	8.5	8.5	NUM
dpc-539	56	13	months	month	NOUN
dpc-539	56	14	)	)	PUNCT
dpc-539	56	15	,	,	PUNCT
dpc-539	56	16	while	while	SCONJ
dpc-539	56	17	reported	report	VERB
dpc-539	56	18	metastases	metastasis	NOUN
dpc-539	56	19	were	be	AUX
dpc-539	56	20	collected	collect	VERB
dpc-539	56	21	within	within	ADP
dpc-539	56	22	0	0	NUM
dpc-539	56	23	to	to	ADP
dpc-539	56	24	49	49	NUM
dpc-539	56	25	months	month	NOUN
dpc-539	56	26	(	(	PUNCT
dpc-539	56	27	mean	mean	NOUN
dpc-539	56	28	11.9	11.9	NUM
dpc-539	56	29	months	month	NOUN
dpc-539	56	30	)	)	PUNCT
dpc-539	56	31	.	.	PUNCT
dpc-539	57	1	metastases	metastasis	NOUN
dpc-539	57	2	were	be	AUX
dpc-539	57	3	identified	identify	VERB
dpc-539	57	4	in	in	ADP
dpc-539	57	5	lymph	lymph	NOUN
dpc-539	57	6	nodes	node	NOUN
dpc-539	57	7	(	(	PUNCT
dpc-539	57	8	31/56	31/56	NUM
dpc-539	57	9	)	)	PUNCT
dpc-539	57	10	,	,	PUNCT
dpc-539	57	11	gastrointestinal	gastrointestinal	ADJ
dpc-539	57	12	tract	tract	NOUN
dpc-539	57	13	(	(	PUNCT
dpc-539	57	14	6/56	6/56	NUM
dpc-539	57	15	)	)	PUNCT
dpc-539	57	16	,	,	PUNCT
dpc-539	57	17	bone	bone	NOUN
dpc-539	57	18	marrow	marrow	NOUN
dpc-539	57	19	(	(	PUNCT
dpc-539	57	20	1/56	1/56	NUM
dpc-539	57	21	)	)	PUNCT
dpc-539	57	22	,	,	PUNCT
dpc-539	57	23	lung	lung	NOUN
dpc-539	57	24	(	(	PUNCT
dpc-539	57	25	1/56	1/56	NUM
dpc-539	57	26	)	)	PUNCT
dpc-539	57	27	,	,	PUNCT
dpc-539	57	28	ovaries	ovary	NOUN
dpc-539	57	29	(	(	PUNCT
dpc-539	57	30	2/56	2/56	NUM
dpc-539	57	31	)	)	PUNCT
dpc-539	57	32	,	,	PUNCT
dpc-539	57	33	liver	liver	NOUN
dpc-539	57	34	(	(	PUNCT
dpc-539	57	35	7/56	7/56	NUM
dpc-539	57	36	)	)	PUNCT
dpc-539	57	37	,	,	PUNCT
dpc-539	57	38	and	and	CCONJ
dpc-539	57	39	skin	skin	NOUN
dpc-539	57	40	sites	site	NOUN
dpc-539	57	41	distant	distant	ADJ
dpc-539	57	42	from	from	ADP
dpc-539	57	43	the	the	DET
dpc-539	57	44	initial	initial	ADJ
dpc-539	57	45	tumor	tumor	NOUN
dpc-539	57	46	area	area	NOUN
dpc-539	57	47	(	(	PUNCT
dpc-539	57	48	8/56	8/56	NUM
dpc-539	57	49	)	)	PUNCT
dpc-539	57	50	.	.	PUNCT
dpc-539	58	1	all	all	DET
dpc-539	58	2	18	18	NUM
dpc-539	58	3	recurrent	recurrent	ADJ
dpc-539	58	4	specimens	specimen	NOUN
dpc-539	58	5	concerned	concerned	ADJ
dpc-539	58	6	cutaneous	cutaneous	ADJ
dpc-539	58	7	tumors	tumor	NOUN
dpc-539	58	8	.	.	PUNCT
dpc-539	59	1	braf	braf	NOUN
dpc-539	59	2	mutation	mutation	NOUN
dpc-539	59	3	distribution	distribution	NOUN
dpc-539	59	4	braf	braf	NOUN
dpc-539	59	5	mutations	mutation	NOUN
dpc-539	59	6	were	be	AUX
dpc-539	59	7	identified	identify	VERB
dpc-539	59	8	in	in	ADP
dpc-539	59	9	a	a	DET
dpc-539	59	10	total	total	NOUN
dpc-539	59	11	of	of	ADP
dpc-539	59	12	92/203	92/203	NUM
dpc-539	59	13	samples	sample	NOUN
dpc-539	59	14	(	(	PUNCT
dpc-539	59	15	45.3	45.3	NUM
dpc-539	59	16	%	%	NOUN
dpc-539	59	17	)	)	PUNCT
dpc-539	59	18	.	.	PUNCT
dpc-539	60	1	analyzing	analyze	VERB
dpc-539	60	2	only	only	ADV
dpc-539	60	3	unique	unique	ADJ
dpc-539	60	4	samples	sample	NOUN
dpc-539	60	5	,	,	PUNCT
dpc-539	60	6	braf	braf	NOUN
dpc-539	60	7	mutations	mutation	NOUN
dpc-539	60	8	were	be	AUX
dpc-539	60	9	identified	identify	VERB
dpc-539	60	10	in	in	ADP
dpc-539	60	11	75/178	75/178	NUM
dpc-539	60	12	samples	sample	NOUN
dpc-539	60	13	(	(	PUNCT
dpc-539	60	14	42.1	42.1	NUM
dpc-539	60	15	%	%	NOUN
dpc-539	60	16	)	)	PUNCT
dpc-539	60	17	.	.	PUNCT
dpc-539	61	1	of	of	ADP
dpc-539	61	2	these	these	DET
dpc-539	61	3	75	75	NUM
dpc-539	61	4	samples	sample	NOUN
dpc-539	61	5	,	,	PUNCT
dpc-539	61	6	63	63	NUM
dpc-539	61	7	(	(	PUNCT
dpc-539	61	8	84	84	NUM
dpc-539	61	9	%	%	NOUN
dpc-539	61	10	)	)	PUNCT
dpc-539	61	11	carried	carry	VERB
dpc-539	61	12	the	the	DET
dpc-539	61	13	v600e	v600e	PROPN
dpc-539	61	14	mutation	mutation	NOUN
dpc-539	61	15	(	(	PUNCT
dpc-539	61	16	c.1799t	c.1799t	NOUN
dpc-539	61	17	>	>	X
dpc-539	61	18	a	a	X
dpc-539	61	19	)	)	PUNCT
dpc-539	61	20	,	,	PUNCT
dpc-539	61	21	10	10	NUM
dpc-539	61	22	samples	sample	NOUN
dpc-539	61	23	(	(	PUNCT
dpc-539	61	24	13.3	13.3	NUM
dpc-539	61	25	%	%	NOUN
dpc-539	61	26	)	)	PUNCT
dpc-539	61	27	the	the	DET
dpc-539	61	28	v600k	v600k	PROPN
dpc-539	61	29	mutation	mutation	NOUN
dpc-539	61	30	(	(	PUNCT
dpc-539	61	31	c.1799_1800tg	c.1799_1800tg	PROPN
dpc-539	61	32	>	>	SYM
dpc-539	61	33	aa	aa	PROPN
dpc-539	61	34	)	)	PUNCT
dpc-539	61	35	,	,	PUNCT
dpc-539	61	36	1	1	NUM
dpc-539	61	37	sample	sample	NOUN
dpc-539	61	38	(	(	PUNCT
dpc-539	61	39	1.3	1.3	NUM
dpc-539	61	40	%	%	NOUN
dpc-539	61	41	)	)	PUNCT
dpc-539	61	42	carried	carry	VERB
dpc-539	61	43	the	the	DET
dpc-539	61	44	v600r	v600r	NOUN
dpc-539	61	45	mutation	mutation	NOUN
dpc-539	61	46	(	(	PUNCT
dpc-539	61	47	c.1798_1799gt	c.1798_1799gt	PROPN
dpc-539	61	48	>	>	SYM
dpc-539	61	49	ag	ag	PROPN
dpc-539	61	50	)	)	PUNCT
dpc-539	61	51	,	,	PUNCT
dpc-539	61	52	and	and	CCONJ
dpc-539	61	53	1	1	NUM
dpc-539	61	54	sample	sample	NOUN
dpc-539	61	55	(	(	PUNCT
dpc-539	61	56	1.3	1.3	NUM
dpc-539	61	57	%	%	NOUN
dpc-539	61	58	)	)	PUNCT
dpc-539	61	59	the	the	DET
dpc-539	61	60	v600a	v600a	PROPN
dpc-539	61	61	(	(	PUNCT
dpc-539	61	62	c.1799t	c.1799t	NOUN
dpc-539	61	63	>	>	NOUN
dpc-539	61	64	c	c	NOUN
dpc-539	61	65	)	)	PUNCT
dpc-539	61	66	mutation	mutation	NOUN
dpc-539	61	67	.	.	PUNCT
dpc-539	62	1	the	the	DET
dpc-539	62	2	v600k	v600k	PROPN
dpc-539	62	3	,	,	PUNCT
dpc-539	62	4	v600r	v600r	NOUN
dpc-539	62	5	,	,	PUNCT
dpc-539	62	6	and	and	CCONJ
dpc-539	62	7	v600a	v600a	NOUN
dpc-539	62	8	mutations	mutation	NOUN
dpc-539	62	9	were	be	AUX
dpc-539	62	10	identified	identify	VERB
dpc-539	62	11	by	by	ADP
dpc-539	62	12	sequencing	sequence	VERB
dpc-539	62	13	only	only	ADV
dpc-539	62	14	,	,	PUNCT
dpc-539	62	15	since	since	SCONJ
dpc-539	62	16	the	the	DET
dpc-539	62	17	molecular	molecular	ADJ
dpc-539	62	18	beacons	beacon	NOUN
dpc-539	62	19	,	,	PUNCT
dpc-539	62	20	as	as	SCONJ
dpc-539	62	21	expected	expect	VERB
dpc-539	62	22	,	,	PUNCT
dpc-539	62	23	could	could	AUX
dpc-539	62	24	not	not	PART
dpc-539	62	25	identify	identify	VERB
dpc-539	62	26	them	they	PRON
dpc-539	62	27	(	(	PUNCT
dpc-539	62	28	figures	figure	NOUN
dpc-539	62	29	1	1	NUM
dpc-539	62	30	and	and	CCONJ
dpc-539	62	31	2	2	NUM
dpc-539	62	32	)	)	PUNCT
dpc-539	62	33	.	.	PUNCT
dpc-539	63	1	in	in	ADP
dpc-539	63	2	12	12	NUM
dpc-539	63	3	patients	patient	NOUN
dpc-539	63	4	,	,	PUNCT
dpc-539	63	5	samples	sample	NOUN
dpc-539	63	6	from	from	ADP
dpc-539	63	7	both	both	DET
dpc-539	63	8	primary	primary	ADJ
dpc-539	63	9	site	site	NOUN
dpc-539	63	10	and	and	CCONJ
dpc-539	63	11	metastasis	metastasis	NOUN
dpc-539	63	12	were	be	AUX
dpc-539	63	13	available	available	ADJ
dpc-539	63	14	:	:	PUNCT
dpc-539	63	15	in	in	ADP
dpc-539	63	16	10/12	10/12	NUM
dpc-539	63	17	(	(	PUNCT
dpc-539	63	18	83.3	83.3	NUM
dpc-539	63	19	%	%	NOUN
dpc-539	63	20	)	)	PUNCT
dpc-539	63	21	cases	case	NOUN
dpc-539	63	22	both	both	DET
dpc-539	63	23	sites	site	NOUN
dpc-539	63	24	had	have	VERB
dpc-539	63	25	the	the	DET
dpc-539	63	26	same	same	ADJ
dpc-539	63	27	genotype	genotype	NOUN
dpc-539	63	28	,	,	PUNCT
dpc-539	63	29	whereas	whereas	SCONJ
dpc-539	63	30	one	one	NUM
dpc-539	63	31	primary	primary	NOUN
dpc-539	63	32	carried	carry	VERB
dpc-539	63	33	a	a	DET
dpc-539	63	34	v600e	v600e	NOUN
dpc-539	63	35	mutation	mutation	NOUN
dpc-539	63	36	not	not	PART
dpc-539	63	37	identified	identify	VERB
dpc-539	63	38	in	in	ADP
dpc-539	63	39	nodal	nodal	ADJ
dpc-539	63	40	metastasis	metastasis	NOUN
dpc-539	63	41	,	,	PUNCT
dpc-539	63	42	and	and	CCONJ
dpc-539	63	43	another	another	PRON
dpc-539	63	44	was	be	AUX
dpc-539	63	45	wt	wt	NOUN
dpc-539	63	46	in	in	ADP
dpc-539	63	47	the	the	DET
dpc-539	63	48	primary	primary	NOUN
dpc-539	63	49	with	with	ADP
dpc-539	63	50	a	a	DET
dpc-539	63	51	v600e	v600e	PROPN
dpc-539	63	52	mutation	mutation	NOUN
dpc-539	63	53	in	in	ADP
dpc-539	63	54	the	the	DET
dpc-539	63	55	visceral	visceral	ADJ
dpc-539	63	56	metastasis	metastasis	NOUN
dpc-539	63	57	.	.	PUNCT
dpc-539	64	1	correlation	correlation	NOUN
dpc-539	64	2	of	of	ADP
dpc-539	64	3	braf	braf	NOUN
dpc-539	64	4	status	status	NOUN
dpc-539	64	5	to	to	ADP
dpc-539	64	6	epidemiological	epidemiological	ADJ
dpc-539	64	7	and	and	CCONJ
dpc-539	64	8	clinical	clinical	ADJ
dpc-539	64	9	parameters	parameter	NOUN
dpc-539	64	10	correlation	correlation	NOUN
dpc-539	64	11	of	of	ADP
dpc-539	64	12	braf	braf	NOUN
dpc-539	64	13	mutation	mutation	NOUN
dpc-539	64	14	status	status	NOUN
dpc-539	64	15	with	with	ADP
dpc-539	64	16	epidemiological	epidemiological	ADJ
dpc-539	64	17	and	and	CCONJ
dpc-539	64	18	clinical	clinical	ADJ
dpc-539	64	19	parameters	parameter	NOUN
dpc-539	64	20	is	be	AUX
dpc-539	64	21	shown	show	VERB
dpc-539	64	22	in	in	ADP
dpc-539	64	23	table	table	NOUN
dpc-539	64	24	1	1	NUM
dpc-539	64	25	.	.	PUNCT
dpc-539	64	26	results	result	NOUN
dpc-539	64	27	for	for	ADP
dpc-539	64	28	sequenced	sequence	VERB
dpc-539	64	29	in	in	ADP
dpc-539	64	30	-	-	PUNCT
dpc-539	64	31	house	house	NOUN
dpc-539	64	32	using	use	VERB
dpc-539	64	33	a	a	DET
dpc-539	64	34	commercially	commercially	ADV
dpc-539	64	35	available	available	ADJ
dpc-539	64	36	kit	kit	NOUN
dpc-539	64	37	(	(	PUNCT
dpc-539	64	38	therascreen	therascreen	NOUN
dpc-539	64	39	braf	braf	NOUN
dpc-539	64	40	pyro	pyro	PROPN
dpc-539	64	41	kit	kit	PROPN
dpc-539	64	42	,	,	PUNCT
dpc-539	64	43	qiagen	qiagen	PROPN
dpc-539	64	44	,	,	PUNCT
dpc-539	64	45	düsseldorf	düsseldorf	PROPN
dpc-539	64	46	,	,	PUNCT
dpc-539	64	47	germany	germany	PROPN
dpc-539	64	48	)	)	PUNCT
dpc-539	65	1	[	[	X
dpc-539	65	2	11	11	NUM
dpc-539	65	3	]	]	PUNCT
dpc-539	65	4	.	.	PUNCT
dpc-539	66	1	primers	primer	NOUN
dpc-539	66	2	and	and	CCONJ
dpc-539	66	3	beacons	beacon	NOUN
dpc-539	66	4	braf	braf	VERB
dpc-539	66	5	primers	primer	NOUN
dpc-539	66	6	and	and	CCONJ
dpc-539	66	7	molecular	molecular	ADJ
dpc-539	66	8	beacons	beacon	NOUN
dpc-539	66	9	were	be	AUX
dpc-539	66	10	designed	design	VERB
dpc-539	66	11	with	with	ADP
dpc-539	66	12	beacon	beacon	NOUN
dpc-539	66	13	designer	designer	NOUN
dpc-539	66	14	7	7	NUM
dpc-539	66	15	(	(	PUNCT
dpc-539	66	16	premier	premier	NOUN
dpc-539	66	17	biosoft	biosoft	NOUN
dpc-539	66	18	,	,	PUNCT
dpc-539	66	19	palo	palo	PROPN
dpc-539	66	20	alto	alto	PROPN
dpc-539	66	21	,	,	PUNCT
dpc-539	66	22	ca	ca	NOUN
dpc-539	66	23	)	)	PUNCT
dpc-539	66	24	.	.	PUNCT
dpc-539	67	1	oligos	oligo	NOUN
dpc-539	67	2	were	be	AUX
dpc-539	67	3	synthesized	synthesize	VERB
dpc-539	67	4	by	by	ADP
dpc-539	67	5	jena	jena	PROPN
dpc-539	67	6	bioscience	bioscience	PROPN
dpc-539	67	7	gmbh	gmbh	PROPN
dpc-539	67	8	(	(	PUNCT
dpc-539	67	9	jena	jena	PROPN
dpc-539	67	10	,	,	PUNCT
dpc-539	67	11	germany	germany	PROPN
dpc-539	67	12	)	)	PUNCT
dpc-539	67	13	.	.	PUNCT
dpc-539	68	1	quality	quality	NOUN
dpc-539	68	2	assurance	assurance	NOUN
dpc-539	68	3	both	both	CCONJ
dpc-539	68	4	the	the	DET
dpc-539	68	5	department	department	NOUN
dpc-539	68	6	of	of	ADP
dpc-539	68	7	cytopathology	cytopathology	PROPN
dpc-539	68	8	and	and	CCONJ
dpc-539	68	9	the	the	DET
dpc-539	68	10	second	second	ADJ
dpc-539	68	11	department	department	NOUN
dpc-539	68	12	of	of	ADP
dpc-539	68	13	pathology	pathology	PROPN
dpc-539	68	14	have	have	AUX
dpc-539	68	15	successfully	successfully	ADV
dpc-539	68	16	participated	participate	VERB
dpc-539	68	17	in	in	ADP
dpc-539	68	18	the	the	DET
dpc-539	68	19	european	european	ADJ
dpc-539	68	20	quality	quality	NOUN
dpc-539	68	21	assurance	assurance	NOUN
dpc-539	68	22	schemes	scheme	NOUN
dpc-539	68	23	of	of	ADP
dpc-539	68	24	the	the	DET
dpc-539	68	25	european	european	ADJ
dpc-539	68	26	society	society	NOUN
dpc-539	68	27	of	of	ADP
dpc-539	68	28	pathology	pathology	NOUN
dpc-539	68	29	for	for	ADP
dpc-539	68	30	molecular	molecular	ADJ
dpc-539	68	31	identification	identification	NOUN
dpc-539	68	32	of	of	ADP
dpc-539	68	33	mutations	mutation	NOUN
dpc-539	68	34	in	in	ADP
dpc-539	68	35	kras	kras	PROPN
dpc-539	68	36	,	,	PUNCT
dpc-539	68	37	nras	nras	PROPN
dpc-539	68	38	,	,	PUNCT
dpc-539	68	39	and	and	CCONJ
dpc-539	68	40	braf	braf	NOUN
dpc-539	68	41	since	since	SCONJ
dpc-539	68	42	2013	2013	NUM
dpc-539	68	43	and	and	CCONJ
dpc-539	68	44	through	through	ADP
dpc-539	68	45	2016	2016	NUM
dpc-539	68	46	.	.	PUNCT
dpc-539	69	1	statistical	statistical	ADJ
dpc-539	69	2	analysis	analysis	NOUN
dpc-539	69	3	statistical	statistical	ADJ
dpc-539	69	4	analysis	analysis	NOUN
dpc-539	69	5	was	be	AUX
dpc-539	69	6	performed	perform	VERB
dpc-539	69	7	using	use	VERB
dpc-539	70	1	ibm	ibm	PROPN
dpc-539	70	2	statistics	statistic	NOUN
dpc-539	70	3	spss	spss	PROPN
dpc-539	70	4	24	24	NUM
dpc-539	70	5	(	(	PUNCT
dpc-539	70	6	ibm	ibm	PROPN
dpc-539	70	7	corporation	corporation	NOUN
dpc-539	70	8	,	,	PUNCT
dpc-539	70	9	new	new	PROPN
dpc-539	70	10	york	york	PROPN
dpc-539	70	11	,	,	PUNCT
dpc-539	70	12	ny	ny	PROPN
dpc-539	70	13	)	)	PUNCT
dpc-539	70	14	and	and	CCONJ
dpc-539	70	15	involved	involve	VERB
dpc-539	70	16	the	the	DET
dpc-539	70	17	fisher	fisher	PROPN
dpc-539	70	18	exact	exact	ADJ
dpc-539	70	19	test	test	NOUN
dpc-539	70	20	for	for	ADP
dpc-539	70	21	2	2	NUM
dpc-539	70	22	×	×	NOUN
dpc-539	70	23	2	2	NUM
dpc-539	70	24	tables	table	NOUN
dpc-539	70	25	,	,	PUNCT
dpc-539	70	26	χ2	χ2	NOUN
dpc-539	70	27	for	for	ADP
dpc-539	70	28	trend	trend	NOUN
dpc-539	70	29	for	for	ADP
dpc-539	70	30	2	2	NUM
dpc-539	70	31	×	×	PROPN
dpc-539	70	32	y	y	PROPN
dpc-539	70	33	tables	table	NOUN
dpc-539	70	34	,	,	PUNCT
dpc-539	70	35	mannwhitney	mannwhitney	ADJ
dpc-539	70	36	test	test	NOUN
dpc-539	70	37	for	for	ADP
dpc-539	70	38	differences	difference	NOUN
dpc-539	70	39	of	of	ADP
dpc-539	70	40	mean	mean	NOUN
dpc-539	70	41	of	of	ADP
dpc-539	70	42	categories	category	NOUN
dpc-539	70	43	,	,	PUNCT
dpc-539	70	44	and	and	CCONJ
dpc-539	70	45	spearman	spearman	NOUN
dpc-539	70	46	correlation	correlation	NOUN
dpc-539	70	47	analysis	analysis	NOUN
dpc-539	70	48	for	for	ADP
dpc-539	70	49	scale	scale	NOUN
dpc-539	70	50	correlations	correlation	NOUN
dpc-539	70	51	.	.	PUNCT
dpc-539	71	1	binary	binary	ADJ
dpc-539	71	2	logistic	logistic	PROPN
dpc-539	71	3	regression	regression	NOUN
dpc-539	71	4	was	be	AUX
dpc-539	71	5	used	use	VERB
dpc-539	71	6	for	for	ADP
dpc-539	71	7	validation	validation	NOUN
dpc-539	71	8	of	of	ADP
dpc-539	71	9	observed	observe	VERB
dpc-539	71	10	differences	difference	NOUN
dpc-539	71	11	of	of	ADP
dpc-539	71	12	braf	braf	NOUN
dpc-539	71	13	status	status	NOUN
dpc-539	71	14	with	with	ADP
dpc-539	71	15	all	all	DET
dpc-539	71	16	mutations	mutation	NOUN
dpc-539	71	17	grouped	group	VERB
dpc-539	71	18	in	in	ADP
dpc-539	71	19	a	a	DET
dpc-539	71	20	single	single	ADJ
dpc-539	71	21	category	category	NOUN
dpc-539	71	22	.	.	PUNCT
dpc-539	72	1	results	result	VERB
dpc-539	72	2	demographic	demographic	ADJ
dpc-539	72	3	and	and	CCONJ
dpc-539	72	4	clinical	clinical	ADJ
dpc-539	72	5	data	datum	NOUN
dpc-539	72	6	one	one	NUM
dpc-539	72	7	hundred	hundred	NUM
dpc-539	72	8	seventy	seventy	NUM
dpc-539	72	9	-	-	PUNCT
dpc-539	72	10	eight	eight	NUM
dpc-539	72	11	melanoma	melanoma	NOUN
dpc-539	72	12	patients	patient	NOUN
dpc-539	72	13	aged	age	VERB
dpc-539	72	14	21	21	NUM
dpc-539	72	15	-	-	SYM
dpc-539	72	16	95	95	NUM
dpc-539	72	17	years	year	NOUN
dpc-539	72	18	(	(	PUNCT
dpc-539	72	19	mean	mean	NOUN
dpc-539	72	20	62.1	62.1	NUM
dpc-539	72	21	years	year	NOUN
dpc-539	72	22	)	)	PUNCT
dpc-539	72	23	were	be	AUX
dpc-539	72	24	included	include	VERB
dpc-539	72	25	in	in	ADP
dpc-539	72	26	the	the	DET
dpc-539	72	27	study	study	NOUN
dpc-539	72	28	.	.	PUNCT
dpc-539	73	1	there	there	PRON
dpc-539	73	2	were	be	VERB
dpc-539	73	3	105	105	NUM
dpc-539	73	4	men	man	NOUN
dpc-539	73	5	with	with	ADP
dpc-539	73	6	a	a	DET
dpc-539	73	7	mean	mean	ADJ
dpc-539	73	8	age	age	NOUN
dpc-539	73	9	of	of	ADP
dpc-539	73	10	62.4	62.4	NUM
dpc-539	73	11	years	year	NOUN
dpc-539	73	12	and	and	CCONJ
dpc-539	73	13	73	73	NUM
dpc-539	73	14	women	woman	NOUN
dpc-539	73	15	with	with	ADP
dpc-539	73	16	a	a	DET
dpc-539	73	17	mean	mean	ADJ
dpc-539	73	18	age	age	NOUN
dpc-539	73	19	of	of	ADP
dpc-539	73	20	61.4	61.4	NUM
dpc-539	73	21	years	year	NOUN
dpc-539	73	22	.	.	PUNCT
dpc-539	74	1	received	receive	VERB
dpc-539	74	2	samples	sample	NOUN
dpc-539	74	3	were	be	AUX
dpc-539	74	4	monitored	monitor	VERB
dpc-539	74	5	to	to	PART
dpc-539	74	6	identify	identify	VERB
dpc-539	74	7	repeated	repeat	VERB
dpc-539	74	8	samples	sample	NOUN
dpc-539	74	9	from	from	ADP
dpc-539	74	10	the	the	DET
dpc-539	74	11	same	same	ADJ
dpc-539	74	12	patients	patient	NOUN
dpc-539	74	13	for	for	ADP
dpc-539	74	14	table	table	NOUN
dpc-539	74	15	1	1	NUM
dpc-539	74	16	.	.	PUNCT
dpc-539	74	17	sample	sample	NOUN
dpc-539	74	18	types	type	NOUN
dpc-539	74	19	and	and	CCONJ
dpc-539	74	20	braf	braf	NOUN
dpc-539	74	21	status	status	NOUN
dpc-539	74	22	braf	braf	NOUN
dpc-539	74	23	status	status	NOUN
dpc-539	74	24	total	total	NOUN
dpc-539	74	25	mutated	mutate	VERB
dpc-539	74	26	(	(	PUNCT
dpc-539	74	27	%	%	INTJ
dpc-539	74	28	)	)	PUNCT
dpc-539	74	29	p	p	NOUN
dpc-539	74	30	wt	wt	ADP
dpc-539	74	31	mutated	mutate	VERB
dpc-539	74	32	patients	patient	NOUN
dpc-539	74	33	103	103	NUM
dpc-539	74	34	75	75	NUM
dpc-539	74	35	178	178	NUM
dpc-539	74	36	42.1	42.1	NUM
dpc-539	74	37	sample	sample	NOUN
dpc-539	74	38	type	type	NOUN
dpc-539	74	39	111	111	NUM
dpc-539	74	40	92	92	NUM
dpc-539	74	41	203	203	NUM
dpc-539	74	42	45.3	45.3	NUM
dpc-539	74	43	primary	primary	ADJ
dpc-539	74	44	melanoma	melanoma	NOUN
dpc-539	74	45	77	77	NUM
dpc-539	74	46	52	52	NUM
dpc-539	74	47	129	129	NUM
dpc-539	74	48	40.3	40.3	NUM
dpc-539	74	49	0.300	0.300	NUM
dpc-539	74	50	metastasis	metastasis	NOUN
dpc-539	74	51	of	of	ADP
dpc-539	74	52	primary	primary	ADJ
dpc-539	74	53	6	6	NUM
dpc-539	74	54	6	6	NUM
dpc-539	74	55	12	12	NUM
dpc-539	74	56	50.0	50.0	NUM
dpc-539	74	57	metastasis	metastasis	NOUN
dpc-539	74	58	w/o	w/o	ADP
dpc-539	74	59	primary	primary	ADJ
dpc-539	74	60	23	23	NUM
dpc-539	74	61	21	21	NUM
dpc-539	74	62	44	44	NUM
dpc-539	74	63	47.7	47.7	NUM
dpc-539	74	64	recurrence	recurrence	NOUN
dpc-539	74	65	of	of	ADP
dpc-539	74	66	primary	primary	ADJ
dpc-539	74	67	2	2	NUM
dpc-539	74	68	11	11	NUM
dpc-539	74	69	13	13	NUM
dpc-539	74	70	84.6	84.6	NUM
dpc-539	74	71	recurrence	recurrence	NOUN
dpc-539	74	72	w/o	w/o	ADP
dpc-539	74	73	primary	primary	ADJ
dpc-539	74	74	3	3	NUM
dpc-539	74	75	2	2	NUM
dpc-539	74	76	5	5	NUM
dpc-539	74	77	40.0	40.0	NUM
dpc-539	74	78	age	age	NOUN
dpc-539	74	79	,	,	PUNCT
dpc-539	74	80	mean	mean	NOUN
dpc-539	74	81	(	(	PUNCT
dpc-539	74	82	95	95	NUM
dpc-539	74	83	%	%	NOUN
dpc-539	74	84	ci	ci	NOUN
dpc-539	74	85	)	)	PUNCT
dpc-539	74	86	(	(	PUNCT
dpc-539	74	87	n	n	NOUN
dpc-539	74	88	=	=	SYM
dpc-539	74	89	178	178	NUM
dpc-539	74	90	)	)	PUNCT
dpc-539	74	91	64.6	64.6	NUM
dpc-539	74	92	(	(	PUNCT
dpc-539	74	93	61.5	61.5	NUM
dpc-539	74	94	-	-	SYM
dpc-539	74	95	67.6	67.6	NUM
dpc-539	74	96	)	)	PUNCT
dpc-539	74	97	58.9	58.9	NUM
dpc-539	74	98	(	(	PUNCT
dpc-539	74	99	55.6	55.6	NUM
dpc-539	74	100	-	-	SYM
dpc-539	74	101	62.2	62.2	NUM
dpc-539	74	102	)	)	PUNCT
dpc-539	74	103	62.1	62.1	NUM
dpc-539	74	104	(	(	PUNCT
dpc-539	74	105	59.9	59.9	NUM
dpc-539	74	106	-	-	SYM
dpc-539	74	107	64.4	64.4	NUM
dpc-539	74	108	)	)	PUNCT
dpc-539	74	109	0.011	0.011	NUM
dpc-539	74	110	sex	sex	NOUN
dpc-539	74	111	(	(	PUNCT
dpc-539	74	112	n	n	NOUN
dpc-539	74	113	=	=	SYM
dpc-539	74	114	178	178	NUM
dpc-539	74	115	)	)	PUNCT
dpc-539	74	116	male	male	NOUN
dpc-539	74	117	55	55	NUM
dpc-539	74	118	50	50	NUM
dpc-539	74	119	105	105	NUM
dpc-539	74	120	47.6	47.6	NUM
dpc-539	74	121	0.090	0.090	NUM
dpc-539	74	122	female	female	NOUN
dpc-539	74	123	48	48	NUM
dpc-539	74	124	25	25	NUM
dpc-539	74	125	73	73	NUM
dpc-539	74	126	34.2	34.2	NUM
dpc-539	74	127	ci	ci	NOUN
dpc-539	74	128	=	=	NOUN
dpc-539	74	129	confidence	confidence	NOUN
dpc-539	74	130	interval	interval	NOUN
dpc-539	74	131	;	;	PUNCT
dpc-539	74	132	wt	wt	NOUN
dpc-539	74	133	=	=	PUNCT
dpc-539	74	134	wild	wild	ADJ
dpc-539	74	135	type	type	NOUN
dpc-539	74	136	.	.	PUNCT
dpc-539	75	1	research	research	NOUN
dpc-539	75	2	|	|	ADV
dpc-539	75	3	dermatol	dermatol	ADJ
dpc-539	75	4	pract	pract	NOUN
dpc-539	75	5	concept	concept	NOUN
dpc-539	75	6	2019;9(1):13	2019;9(1):13	NUM
dpc-539	75	7	57	57	NUM
dpc-539	75	8	figure	figure	NOUN
dpc-539	75	9	1	1	NUM
dpc-539	75	10	.	.	PUNCT
dpc-539	76	1	(	(	PUNCT
dpc-539	76	2	continues	continue	VERB
dpc-539	76	3	)	)	PUNCT
dpc-539	76	4	58	58	NUM
dpc-539	76	5	research	research	NOUN
dpc-539	76	6	|	|	ADV
dpc-539	77	1	dermatol	dermatol	NOUN
dpc-539	77	2	pract	pract	NOUN
dpc-539	77	3	concept	concept	NOUN
dpc-539	77	4	2019;9(1):13	2019;9(1):13	NUM
dpc-539	77	5	figure	figure	NOUN
dpc-539	77	6	1	1	NUM
dpc-539	77	7	.	.	PUNCT
dpc-539	77	8	real	real	ADJ
dpc-539	77	9	-	-	PUNCT
dpc-539	77	10	time	time	NOUN
dpc-539	77	11	polymerase	polymerase	NOUN
dpc-539	77	12	chain	chain	NOUN
dpc-539	77	13	reaction	reaction	NOUN
dpc-539	77	14	plots	plot	NOUN
dpc-539	77	15	of	of	ADP
dpc-539	77	16	serial	serial	ADJ
dpc-539	77	17	dilutions	dilution	NOUN
dpc-539	77	18	depicting	depict	VERB
dpc-539	77	19	that	that	PRON
dpc-539	77	20	even	even	ADV
dpc-539	77	21	rare	rare	ADJ
dpc-539	77	22	mutation	mutation	NOUN
dpc-539	77	23	-	-	PUNCT
dpc-539	77	24	harboring	harbor	VERB
dpc-539	77	25	populations	population	NOUN
dpc-539	77	26	be	be	AUX
dpc-539	77	27	identified	identify	VERB
dpc-539	77	28	using	use	VERB
dpc-539	77	29	molecular	molecular	ADJ
dpc-539	77	30	beacons	beacon	NOUN
dpc-539	77	31	(	(	PUNCT
dpc-539	77	32	red	red	ADJ
dpc-539	77	33	-	-	PUNCT
dpc-539	77	34	colored	colored	ADJ
dpc-539	77	35	line	line	NOUN
dpc-539	77	36	=	=	SYM
dpc-539	77	37	mutant	mutant	NOUN
dpc-539	77	38	;	;	PUNCT
dpc-539	77	39	green	green	ADJ
dpc-539	77	40	-	-	PUNCT
dpc-539	77	41	colored	color	VERB
dpc-539	77	42	line	line	NOUN
dpc-539	77	43	=	=	SYM
dpc-539	77	44	wild	wild	ADJ
dpc-539	77	45	type	type	NOUN
dpc-539	77	46	)	)	PUNCT
dpc-539	77	47	.	.	PUNCT
dpc-539	78	1	[	[	X
dpc-539	78	2	copyright	copyright	NOUN
dpc-539	78	3	:	:	PUNCT
dpc-539	78	4	©	©	PROPN
dpc-539	78	5	2019	2019	NUM
dpc-539	78	6	spathis	spathis	NOUN
dpc-539	78	7	et	et	PROPN
dpc-539	78	8	al	al	PROPN
dpc-539	78	9	.	.	PROPN
dpc-539	78	10	]	]	PUNCT
dpc-539	79	1	[	[	X
dpc-539	79	2	copyright	copyright	NOUN
dpc-539	79	3	:	:	PUNCT
dpc-539	79	4	©	©	PROPN
dpc-539	79	5	2019	2019	NUM
dpc-539	79	6	spathis	spathis	NOUN
dpc-539	79	7	et	et	PROPN
dpc-539	79	8	 	 	SPACE
dpc-539	79	9	al	al	PROPN
dpc-539	79	10	.	.	PROPN
dpc-539	79	11	]	]	PUNCT
dpc-539	79	12	figure	figure	NOUN
dpc-539	79	13	1	1	NUM
dpc-539	79	14	,	,	PUNCT
dpc-539	79	15	continued	continued	ADJ
dpc-539	79	16	research	research	NOUN
dpc-539	79	17	|	|	ADV
dpc-539	79	18	dermatol	dermatol	ADJ
dpc-539	79	19	pract	pract	NOUN
dpc-539	79	20	concept	concept	NOUN
dpc-539	79	21	2019;9(1):13	2019;9(1):13	NUM
dpc-539	79	22	59	59	NUM
dpc-539	79	23	test	test	NOUN
dpc-539	79	24	)	)	PUNCT
dpc-539	79	25	,	,	PUNCT
dpc-539	79	26	although	although	SCONJ
dpc-539	79	27	limited	limited	ADJ
dpc-539	79	28	samples	sample	NOUN
dpc-539	79	29	were	be	AUX
dpc-539	79	30	available	available	ADJ
dpc-539	79	31	.	.	PUNCT
dpc-539	80	1	patients	patient	NOUN
dpc-539	80	2	with	with	ADP
dpc-539	80	3	melanoma	melanoma	NOUN
dpc-539	80	4	metastasis	metastasis	NOUN
dpc-539	80	5	showed	show	VERB
dpc-539	80	6	a	a	DET
dpc-539	80	7	slightly	slightly	ADV
dpc-539	80	8	increased	increase	VERB
dpc-539	80	9	frequency	frequency	NOUN
dpc-539	80	10	of	of	ADP
dpc-539	80	11	braf	braf	NOUN
dpc-539	80	12	mutations	mutation	NOUN
dpc-539	80	13	(	(	PUNCT
dpc-539	80	14	37	37	NUM
dpc-539	80	15	%	%	NOUN
dpc-539	80	16	vs	vs	ADP
dpc-539	80	17	30.7	30.7	NUM
dpc-539	80	18	%	%	NOUN
dpc-539	80	19	,	,	PUNCT
dpc-539	80	20	p	p	X
dpc-539	80	21	=	=	NOUN
dpc-539	80	22	0.413	0.413	NUM
dpc-539	80	23	,	,	PUNCT
dpc-539	80	24	fisher	fisher	PROPN
dpc-539	80	25	exact	exact	ADJ
dpc-539	80	26	test	test	NOUN
dpc-539	80	27	)	)	PUNCT
dpc-539	80	28	,	,	PUNCT
dpc-539	80	29	without	without	ADP
dpc-539	80	30	reaching	reach	VERB
dpc-539	80	31	statistical	statistical	ADJ
dpc-539	80	32	significance	significance	NOUN
dpc-539	80	33	.	.	PUNCT
dpc-539	81	1	these	these	DET
dpc-539	81	2	results	result	NOUN
dpc-539	81	3	are	be	AUX
dpc-539	81	4	only	only	ADV
dpc-539	81	5	indicative	indicative	ADJ
dpc-539	81	6	because	because	SCONJ
dpc-539	81	7	we	we	PRON
dpc-539	81	8	analyzed	analyze	VERB
dpc-539	81	9	reported	report	VERB
dpc-539	81	10	metastases	metastasis	NOUN
dpc-539	81	11	and	and	CCONJ
dpc-539	81	12	recurrences	recurrence	NOUN
dpc-539	81	13	that	that	PRON
dpc-539	81	14	had	have	AUX
dpc-539	81	15	been	be	AUX
dpc-539	81	16	referred	refer	VERB
dpc-539	81	17	to	to	ADP
dpc-539	81	18	our	our	PRON
dpc-539	81	19	laboratory	laboratory	NOUN
dpc-539	81	20	.	.	PUNCT
dpc-539	82	1	association	association	NOUN
dpc-539	82	2	of	of	ADP
dpc-539	82	3	braf	braf	PROPN
dpc-539	82	4	status	status	NOUN
dpc-539	82	5	to	to	ADP
dpc-539	82	6	histopathological	histopathological	ADJ
dpc-539	82	7	parameters	parameter	NOUN
dpc-539	82	8	in	in	ADP
dpc-539	82	9	primary	primary	ADJ
dpc-539	82	10	mms	mms	NOUN
dpc-539	82	11	(	(	PUNCT
dpc-539	82	12	table	table	NOUN
dpc-539	82	13	4	4	NUM
dpc-539	82	14	)	)	PUNCT
dpc-539	82	15	,	,	PUNCT
dpc-539	82	16	mutated	mutate	VERB
dpc-539	82	17	braf	braf	NOUN
dpc-539	82	18	was	be	AUX
dpc-539	82	19	significantly	significantly	ADV
dpc-539	82	20	more	more	ADV
dpc-539	82	21	common	common	ADJ
dpc-539	82	22	in	in	ADP
dpc-539	82	23	ulcerated	ulcerated	ADJ
dpc-539	82	24	tumors	tumor	NOUN
dpc-539	82	25	(	(	PUNCT
dpc-539	82	26	51.7	51.7	NUM
dpc-539	82	27	%	%	NOUN
dpc-539	82	28	vs	vs	ADP
dpc-539	82	29	31	31	NUM
dpc-539	82	30	%	%	NOUN
dpc-539	82	31	,	,	PUNCT
dpc-539	82	32	p	p	X
dpc-539	82	33	=	=	NOUN
dpc-539	82	34	0.002	0.002	NUM
dpc-539	82	35	,	,	PUNCT
dpc-539	82	36	fisher	fisher	PROPN
dpc-539	82	37	exact	exact	ADJ
dpc-539	82	38	test	test	NOUN
dpc-539	82	39	)	)	PUNCT
dpc-539	82	40	or	or	CCONJ
dpc-539	82	41	when	when	SCONJ
dpc-539	82	42	the	the	DET
dpc-539	82	43	adjacent	adjacent	ADJ
dpc-539	82	44	dermis	dermis	NOUN
dpc-539	82	45	lacked	lack	VERB
dpc-539	82	46	solar	solar	ADJ
dpc-539	82	47	elastosis	elastosis	NOUN
dpc-539	82	48	(	(	PUNCT
dpc-539	82	49	44.3	44.3	NUM
dpc-539	82	50	%	%	NOUN
dpc-539	82	51	vs	vs	ADP
dpc-539	82	52	7.1	7.1	NUM
dpc-539	82	53	%	%	NOUN
dpc-539	82	54	,	,	PUNCT
dpc-539	82	55	p	p	NOUN
dpc-539	82	56	=	=	NOUN
dpc-539	82	57	0.008	0.008	NUM
dpc-539	82	58	,	,	PUNCT
dpc-539	82	59	fisher	fisher	PROPN
dpc-539	82	60	exact	exact	ADJ
dpc-539	82	61	test	test	NOUN
dpc-539	82	62	)	)	PUNCT
dpc-539	82	63	.	.	PUNCT
dpc-539	83	1	in	in	ADP
dpc-539	83	2	contrast	contrast	NOUN
dpc-539	83	3	,	,	PUNCT
dpc-539	83	4	the	the	DET
dpc-539	83	5	number	number	NOUN
dpc-539	83	6	of	of	ADP
dpc-539	83	7	mitoses	mitose	NOUN
dpc-539	83	8	,	,	PUNCT
dpc-539	83	9	presence	presence	NOUN
dpc-539	83	10	of	of	ADP
dpc-539	83	11	tumor	tumor	NOUN
dpc-539	83	12	-	-	PUNCT
dpc-539	83	13	infiltrating	infiltrate	VERB
dpc-539	83	14	lymphocytes	lymphocyte	NOUN
dpc-539	83	15	(	(	PUNCT
dpc-539	83	16	tils	til	NOUN
dpc-539	83	17	)	)	PUNCT
dpc-539	83	18	,	,	PUNCT
dpc-539	83	19	clark	clark	NOUN
dpc-539	83	20	level	level	NOUN
dpc-539	83	21	,	,	PUNCT
dpc-539	83	22	or	or	CCONJ
dpc-539	83	23	breslow	breslow	NOUN
dpc-539	83	24	thickness	thickness	NOUN
dpc-539	83	25	were	be	AUX
dpc-539	83	26	not	not	PART
dpc-539	83	27	significantly	significantly	ADV
dpc-539	83	28	related	relate	VERB
dpc-539	83	29	to	to	ADP
dpc-539	83	30	braf	braf	NOUN
dpc-539	83	31	mutation	mutation	NOUN
dpc-539	83	32	status	status	NOUN
dpc-539	83	33	,	,	PUNCT
dpc-539	83	34	apart	apart	ADV
dpc-539	83	35	primary	primary	ADJ
dpc-539	83	36	and	and	CCONJ
dpc-539	83	37	metastatic	metastatic	ADJ
dpc-539	83	38	mms	mms	NOUN
dpc-539	83	39	are	be	AUX
dpc-539	83	40	shown	show	VERB
dpc-539	83	41	in	in	ADP
dpc-539	83	42	tables	table	NOUN
dpc-539	83	43	2	2	NUM
dpc-539	83	44	and	and	CCONJ
dpc-539	83	45	3	3	NUM
dpc-539	83	46	,	,	PUNCT
dpc-539	83	47	respectively	respectively	ADV
dpc-539	83	48	.	.	PUNCT
dpc-539	84	1	briefly	briefly	NOUN
dpc-539	84	2	,	,	PUNCT
dpc-539	84	3	braf	braf	NOUN
dpc-539	84	4	mutations	mutation	NOUN
dpc-539	84	5	were	be	AUX
dpc-539	84	6	more	more	ADV
dpc-539	84	7	common	common	ADJ
dpc-539	84	8	among	among	ADP
dpc-539	84	9	younger	young	ADJ
dpc-539	84	10	patients	patient	NOUN
dpc-539	84	11	(	(	PUNCT
dpc-539	84	12	p	p	X
dpc-539	84	13	=	=	NOUN
dpc-539	84	14	0.011	0.011	NUM
dpc-539	84	15	,	,	PUNCT
dpc-539	84	16	mann	mann	PROPN
dpc-539	84	17	-	-	PUNCT
dpc-539	84	18	whitney	whitney	PROPN
dpc-539	84	19	u	u	PROPN
dpc-539	84	20	test	test	NOUN
dpc-539	84	21	)	)	PUNCT
dpc-539	84	22	,	,	PUNCT
dpc-539	84	23	while	while	SCONJ
dpc-539	84	24	the	the	DET
dpc-539	84	25	same	same	ADJ
dpc-539	84	26	trend	trend	NOUN
dpc-539	84	27	was	be	AUX
dpc-539	84	28	present	present	ADJ
dpc-539	84	29	for	for	ADP
dpc-539	84	30	primary	primary	ADJ
dpc-539	84	31	and	and	CCONJ
dpc-539	84	32	metastatic	metastatic	ADJ
dpc-539	84	33	samples	sample	NOUN
dpc-539	84	34	,	,	PUNCT
dpc-539	84	35	however	however	ADV
dpc-539	84	36	without	without	ADP
dpc-539	84	37	reaching	reach	VERB
dpc-539	84	38	statistical	statistical	ADJ
dpc-539	84	39	significance	significance	NOUN
dpc-539	84	40	.	.	PUNCT
dpc-539	85	1	primary	primary	ADJ
dpc-539	85	2	mms	mms	NOUN
dpc-539	85	3	of	of	ADP
dpc-539	85	4	the	the	DET
dpc-539	85	5	torso	torso	NOUN
dpc-539	85	6	showed	show	VERB
dpc-539	85	7	a	a	DET
dpc-539	85	8	slightly	slightly	ADV
dpc-539	85	9	increased	increase	VERB
dpc-539	85	10	mutation	mutation	NOUN
dpc-539	85	11	frequency	frequency	NOUN
dpc-539	85	12	,	,	PUNCT
dpc-539	85	13	compared	compare	VERB
dpc-539	85	14	with	with	ADP
dpc-539	85	15	those	those	PRON
dpc-539	85	16	located	locate	VERB
dpc-539	85	17	at	at	ADP
dpc-539	85	18	the	the	DET
dpc-539	85	19	extremities	extremity	NOUN
dpc-539	85	20	or	or	CCONJ
dpc-539	85	21	head	head	NOUN
dpc-539	85	22	and	and	CCONJ
dpc-539	85	23	neck	neck	NOUN
dpc-539	85	24	area	area	NOUN
dpc-539	85	25	(	(	PUNCT
dpc-539	85	26	40.3	40.3	NUM
dpc-539	85	27	%	%	NOUN
dpc-539	85	28	vs	vs	ADP
dpc-539	85	29	36.3	36.3	NUM
dpc-539	85	30	%	%	NOUN
dpc-539	85	31	,	,	PUNCT
dpc-539	85	32	p	p	X
dpc-539	85	33	=	=	SYM
dpc-539	85	34	0.269	0.269	NUM
dpc-539	85	35	,	,	PUNCT
dpc-539	85	36	fisher	fisher	PROPN
dpc-539	85	37	exact	exact	ADJ
dpc-539	85	38	test	test	NOUN
dpc-539	85	39	)	)	PUNCT
dpc-539	85	40	.	.	PUNCT
dpc-539	86	1	cutaneous	cutaneous	ADJ
dpc-539	86	2	and	and	CCONJ
dpc-539	86	3	lymph	lymph	VERB
dpc-539	86	4	node	node	ADJ
dpc-539	86	5	metastases	metastasis	NOUN
dpc-539	86	6	also	also	ADV
dpc-539	86	7	displayed	display	VERB
dpc-539	86	8	higher	high	ADJ
dpc-539	86	9	mutation	mutation	NOUN
dpc-539	86	10	frequency	frequency	NOUN
dpc-539	86	11	,	,	PUNCT
dpc-539	86	12	again	again	ADV
dpc-539	86	13	without	without	ADP
dpc-539	86	14	reaching	reach	VERB
dpc-539	86	15	statistical	statistical	ADJ
dpc-539	86	16	significance	significance	NOUN
dpc-539	86	17	(	(	PUNCT
dpc-539	86	18	53.8	53.8	NUM
dpc-539	86	19	%	%	NOUN
dpc-539	86	20	vs	vs	ADP
dpc-539	86	21	35.2	35.2	NUM
dpc-539	86	22	,	,	PUNCT
dpc-539	86	23	p	p	NOUN
dpc-539	86	24	=	=	PROPN
dpc-539	86	25	0.143	0.143	NUM
dpc-539	86	26	,	,	PUNCT
dpc-539	86	27	fisher	fisher	PROPN
dpc-539	86	28	exact	exact	ADJ
dpc-539	86	29	test	test	NOUN
dpc-539	86	30	)	)	PUNCT
dpc-539	86	31	.	.	PUNCT
dpc-539	87	1	mutations	mutation	NOUN
dpc-539	87	2	were	be	AUX
dpc-539	87	3	more	more	ADV
dpc-539	87	4	common	common	ADJ
dpc-539	87	5	in	in	ADP
dpc-539	87	6	men	man	NOUN
dpc-539	87	7	,	,	PUNCT
dpc-539	87	8	although	although	SCONJ
dpc-539	87	9	this	this	PRON
dpc-539	87	10	was	be	AUX
dpc-539	87	11	statistically	statistically	ADV
dpc-539	87	12	significant	significant	ADJ
dpc-539	87	13	only	only	ADV
dpc-539	87	14	in	in	ADP
dpc-539	87	15	metastatic	metastatic	ADJ
dpc-539	87	16	samples	sample	NOUN
dpc-539	87	17	(	(	PUNCT
dpc-539	87	18	p	p	X
dpc-539	87	19	=	=	PROPN
dpc-539	87	20	0.029	0.029	NUM
dpc-539	87	21	,	,	PUNCT
dpc-539	87	22	fisher	fisher	PROPN
dpc-539	87	23	exact	exact	ADJ
dpc-539	87	24	test	test	NOUN
dpc-539	87	25	)	)	PUNCT
dpc-539	87	26	.	.	PUNCT
dpc-539	88	1	patients	patient	NOUN
dpc-539	88	2	with	with	ADP
dpc-539	88	3	a	a	DET
dpc-539	88	4	recurrent	recurrent	ADJ
dpc-539	88	5	melanoma	melanoma	NOUN
dpc-539	88	6	had	have	VERB
dpc-539	88	7	higher	high	ADJ
dpc-539	88	8	mutation	mutation	NOUN
dpc-539	88	9	frequency	frequency	NOUN
dpc-539	88	10	(	(	PUNCT
dpc-539	88	11	13/18	13/18	NUM
dpc-539	88	12	vs	vs	ADP
dpc-539	88	13	41/116	41/116	NUM
dpc-539	88	14	,	,	PUNCT
dpc-539	88	15	p	p	X
dpc-539	88	16	=	=	NOUN
dpc-539	88	17	0.004	0.004	NUM
dpc-539	88	18	,	,	PUNCT
dpc-539	88	19	fisher	fisher	PROPN
dpc-539	88	20	exact	exact	ADJ
dpc-539	88	21	figure	figure	NOUN
dpc-539	88	22	2	2	NUM
dpc-539	88	23	.	.	PUNCT
dpc-539	89	1	sequencing	sequence	VERB
dpc-539	89	2	chromatographs	chromatograph	NOUN
dpc-539	89	3	of	of	ADP
dpc-539	89	4	a	a	DET
dpc-539	89	5	wild	wild	ADJ
dpc-539	89	6	-	-	PUNCT
dpc-539	89	7	type	type	NOUN
dpc-539	89	8	sample	sample	NOUN
dpc-539	89	9	and	and	CCONJ
dpc-539	89	10	samples	sample	NOUN
dpc-539	89	11	carrying	carry	VERB
dpc-539	89	12	a	a	DET
dpc-539	89	13	v600e	v600e	PROPN
dpc-539	89	14	mutation	mutation	NOUN
dpc-539	89	15	,	,	PUNCT
dpc-539	89	16	a	a	DET
dpc-539	89	17	v600k	v600k	PROPN
dpc-539	89	18	mutation	mutation	NOUN
dpc-539	89	19	,	,	PUNCT
dpc-539	89	20	and	and	CCONJ
dpc-539	89	21	a	a	DET
dpc-539	89	22	v600r	v600r	ADJ
dpc-539	89	23	mutation	mutation	NOUN
dpc-539	89	24	.	.	PUNCT
dpc-539	90	1	[	[	X
dpc-539	90	2	copyright	copyright	NOUN
dpc-539	90	3	:	:	PUNCT
dpc-539	90	4	©	©	PROPN
dpc-539	90	5	2019	2019	NUM
dpc-539	90	6	spathis	spathis	NOUN
dpc-539	90	7	et	et	PROPN
dpc-539	90	8	 	 	SPACE
dpc-539	90	9	al	al	PROPN
dpc-539	90	10	.	.	PROPN
dpc-539	90	11	]	]	PUNCT
dpc-539	90	12	table	table	NOUN
dpc-539	90	13	2	2	NUM
dpc-539	90	14	.	.	PUNCT
dpc-539	90	15	patient	patient	ADJ
dpc-539	90	16	characteristics	characteristic	NOUN
dpc-539	90	17	of	of	ADP
dpc-539	90	18	primary	primary	ADJ
dpc-539	90	19	melanomas	melanoma	NOUN
dpc-539	90	20	and	and	CCONJ
dpc-539	90	21	braf	braf	NOUN
dpc-539	90	22	status	status	NOUN
dpc-539	90	23	braf	braf	NOUN
dpc-539	90	24	status	status	NOUN
dpc-539	90	25	total	total	NOUN
dpc-539	90	26	mutated	mutate	VERB
dpc-539	90	27	(	(	PUNCT
dpc-539	90	28	%	%	INTJ
dpc-539	90	29	)	)	PUNCT
dpc-539	90	30	p	p	NOUN
dpc-539	90	31	wt	wt	ADP
dpc-539	90	32	mutated	mutate	VERB
dpc-539	90	33	age	age	NOUN
dpc-539	90	34	,	,	PUNCT
dpc-539	90	35	mean	mean	NOUN
dpc-539	90	36	(	(	PUNCT
dpc-539	90	37	95	95	NUM
dpc-539	90	38	%	%	NOUN
dpc-539	90	39	ci	ci	NOUN
dpc-539	90	40	)	)	PUNCT
dpc-539	90	41	(	(	PUNCT
dpc-539	90	42	n	n	NOUN
dpc-539	90	43	=	=	SYM
dpc-539	90	44	129	129	NUM
dpc-539	90	45	)	)	PUNCT
dpc-539	90	46	65.3	65.3	NUM
dpc-539	90	47	(	(	PUNCT
dpc-539	90	48	61.8	61.8	NUM
dpc-539	90	49	-	-	SYM
dpc-539	90	50	68.7	68.7	NUM
dpc-539	90	51	)	)	PUNCT
dpc-539	90	52	60.2	60.2	NUM
dpc-539	90	53	(	(	PUNCT
dpc-539	90	54	56.1	56.1	NUM
dpc-539	90	55	-	-	SYM
dpc-539	90	56	64.3	64.3	NUM
dpc-539	90	57	)	)	PUNCT
dpc-539	90	58	63.2	63.2	NUM
dpc-539	90	59	(	(	PUNCT
dpc-539	90	60	60.5	60.5	NUM
dpc-539	90	61	-	-	SYM
dpc-539	90	62	65.8	65.8	NUM
dpc-539	90	63	)	)	PUNCT
dpc-539	90	64	0.086	0.086	NUM
dpc-539	90	65	sex	sex	NOUN
dpc-539	90	66	(	(	PUNCT
dpc-539	90	67	n	n	NOUN
dpc-539	90	68	=	=	SYM
dpc-539	90	69	129	129	NUM
dpc-539	90	70	)	)	PUNCT
dpc-539	90	71	male	male	NOUN
dpc-539	90	72	43	43	NUM
dpc-539	90	73	35	35	NUM
dpc-539	90	74	78	78	NUM
dpc-539	90	75	44.9	44.9	NUM
dpc-539	90	76	0.205	0.205	NUM
dpc-539	90	77	female	female	NOUN
dpc-539	90	78	34	34	NUM
dpc-539	90	79	17	17	NUM
dpc-539	90	80	51	51	NUM
dpc-539	90	81	33.3	33.3	NUM
dpc-539	90	82	primary	primary	ADJ
dpc-539	90	83	site	site	NOUN
dpc-539	90	84	(	(	PUNCT
dpc-539	90	85	n	n	NOUN
dpc-539	90	86	=	=	SYM
dpc-539	90	87	129	129	NUM
dpc-539	90	88	)	)	PUNCT
dpc-539	90	89	head	head	NOUN
dpc-539	90	90	and	and	CCONJ
dpc-539	90	91	neck	neck	NOUN
dpc-539	90	92	17	17	NUM
dpc-539	90	93	9	9	NUM
dpc-539	90	94	26	26	NUM
dpc-539	90	95	34.6	34.6	NUM
dpc-539	90	96	0.254	0.254	NUM
dpc-539	90	97	extremities	extremity	NOUN
dpc-539	90	98	34	34	NUM
dpc-539	90	99	20	20	NUM
dpc-539	90	100	54	54	NUM
dpc-539	90	101	37.0	37.0	NUM
dpc-539	90	102	torso	torso	NOUN
dpc-539	90	103	26	26	NUM
dpc-539	90	104	23	23	NUM
dpc-539	90	105	49	49	NUM
dpc-539	90	106	40.3	40.3	NUM
dpc-539	90	107	ci	ci	NOUN
dpc-539	90	108	=	=	NOUN
dpc-539	90	109	confidence	confidence	NOUN
dpc-539	90	110	interval	interval	NOUN
dpc-539	90	111	;	;	PUNCT
dpc-539	90	112	wt	wt	NOUN
dpc-539	90	113	=	=	PUNCT
dpc-539	90	114	wild	wild	ADJ
dpc-539	90	115	type	type	NOUN
dpc-539	90	116	.	.	PUNCT
dpc-539	91	1	60	60	NUM
dpc-539	91	2	research	research	NOUN
dpc-539	91	3	|	|	ADV
dpc-539	91	4	dermatol	dermatol	ADJ
dpc-539	91	5	pract	pract	NOUN
dpc-539	91	6	concept	concept	NOUN
dpc-539	91	7	2019;9(1):13	2019;9(1):13	NUM
dpc-539	91	8	significance	significance	NOUN
dpc-539	91	9	,	,	PUNCT
dpc-539	91	10	as	as	SCONJ
dpc-539	91	11	some	some	PRON
dpc-539	91	12	of	of	ADP
dpc-539	91	13	them	they	PRON
dpc-539	91	14	did	do	VERB
dpc-539	91	15	in	in	ADP
dpc-539	91	16	previous	previous	ADJ
dpc-539	91	17	studies	study	NOUN
dpc-539	91	18	[	[	X
dpc-539	91	19	12	12	NUM
dpc-539	91	20	,	,	PUNCT
dpc-539	91	21	13	13	NUM
dpc-539	91	22	]	]	PUNCT
dpc-539	91	23	.	.	PUNCT
dpc-539	92	1	almost	almost	ADV
dpc-539	92	2	all	all	DET
dpc-539	92	3	pairs	pair	NOUN
dpc-539	92	4	of	of	ADP
dpc-539	92	5	primary	primary	ADJ
dpc-539	92	6	and	and	CCONJ
dpc-539	92	7	metastatic	metastatic	ADJ
dpc-539	92	8	sites	site	NOUN
dpc-539	92	9	had	have	VERB
dpc-539	92	10	the	the	DET
dpc-539	92	11	same	same	ADJ
dpc-539	92	12	genotype	genotype	NOUN
dpc-539	92	13	,	,	PUNCT
dpc-539	92	14	except	except	SCONJ
dpc-539	92	15	2	2	NUM
dpc-539	92	16	patients	patient	NOUN
dpc-539	92	17	,	,	PUNCT
dpc-539	92	18	in	in	ADP
dpc-539	92	19	whom	whom	PRON
dpc-539	92	20	a	a	DET
dpc-539	92	21	discordance	discordance	NOUN
dpc-539	92	22	of	of	ADP
dpc-539	92	23	braf	braf	NOUN
dpc-539	92	24	status	status	NOUN
dpc-539	92	25	between	between	ADP
dpc-539	92	26	primary	primary	ADJ
dpc-539	92	27	site	site	NOUN
dpc-539	92	28	and	and	CCONJ
dpc-539	92	29	metastasis	metastasis	NOUN
dpc-539	92	30	was	be	AUX
dpc-539	92	31	found	find	VERB
dpc-539	92	32	[	[	X
dpc-539	92	33	7	7	NUM
dpc-539	92	34	,	,	PUNCT
dpc-539	92	35	14	14	NUM
dpc-539	92	36	]	]	PUNCT
dpc-539	92	37	.	.	PUNCT
dpc-539	93	1	in	in	ADP
dpc-539	93	2	a	a	DET
dpc-539	93	3	recent	recent	ADJ
dpc-539	93	4	meta	meta	ADJ
dpc-539	93	5	-	-	PUNCT
dpc-539	93	6	analysis	analysis	NOUN
dpc-539	93	7	,	,	PUNCT
dpc-539	93	8	braf	braf	NOUN
dpc-539	93	9	and	and	CCONJ
dpc-539	93	10	nras	nras	PROPN
dpc-539	93	11	mutations	mutation	NOUN
dpc-539	93	12	were	be	AUX
dpc-539	93	13	associated	associate	VERB
dpc-539	93	14	with	with	ADP
dpc-539	93	15	histological	histological	ADJ
dpc-539	93	16	subtype	subtype	NOUN
dpc-539	93	17	and	and	CCONJ
dpc-539	93	18	tumor	tumor	NOUN
dpc-539	93	19	site	site	NOUN
dpc-539	93	20	,	,	PUNCT
dpc-539	93	21	but	but	CCONJ
dpc-539	93	22	not	not	PART
dpc-539	93	23	with	with	ADP
dpc-539	93	24	patient	patient	ADJ
dpc-539	93	25	age	age	NOUN
dpc-539	93	26	or	or	CCONJ
dpc-539	93	27	sex	sex	NOUN
dpc-539	94	1	[	[	X
dpc-539	94	2	15	15	NUM
dpc-539	94	3	]	]	PUNCT
dpc-539	94	4	.	.	PUNCT
dpc-539	95	1	braf	braf	NOUN
dpc-539	95	2	mutations	mutation	NOUN
dpc-539	95	3	were	be	AUX
dpc-539	95	4	frequently	frequently	ADV
dpc-539	95	5	detected	detect	VERB
dpc-539	95	6	in	in	ADP
dpc-539	95	7	patients	patient	NOUN
dpc-539	95	8	with	with	ADP
dpc-539	95	9	ssm	ssm	PROPN
dpc-539	95	10	and	and	CCONJ
dpc-539	95	11	in	in	ADP
dpc-539	95	12	mms	mms	NOUN
dpc-539	95	13	arising	arise	VERB
dpc-539	95	14	in	in	ADP
dpc-539	95	15	non	non	ADJ
dpc-539	95	16	–	–	PUNCT
dpc-539	95	17	chronically	chronically	ADV
dpc-539	95	18	sun	sun	NOUN
dpc-539	95	19	-	-	PUNCT
dpc-539	95	20	damaged	damage	VERB
dpc-539	95	21	skin	skin	NOUN
dpc-539	95	22	.	.	PUNCT
dpc-539	96	1	in	in	ADP
dpc-539	96	2	contrast	contrast	NOUN
dpc-539	96	3	,	,	PUNCT
dpc-539	96	4	nras	nras	PROPN
dpc-539	96	5	mutations	mutation	NOUN
dpc-539	96	6	were	be	AUX
dpc-539	96	7	more	more	ADV
dpc-539	96	8	frequent	frequent	ADJ
dpc-539	96	9	in	in	ADP
dpc-539	96	10	patients	patient	NOUN
dpc-539	96	11	with	with	ADP
dpc-539	96	12	nm	nm	NOUN
dpc-539	96	13	and	and	CCONJ
dpc-539	96	14	in	in	ADP
dpc-539	96	15	mms	mms	NOUN
dpc-539	96	16	arising	arise	VERB
dpc-539	96	17	in	in	ADP
dpc-539	96	18	chronically	chronically	ADV
dpc-539	96	19	sun	sun	NOUN
dpc-539	96	20	-	-	PUNCT
dpc-539	96	21	damaged	damage	VERB
dpc-539	96	22	skin	skin	NOUN
dpc-539	96	23	[	[	X
dpc-539	96	24	15	15	NUM
dpc-539	96	25	]	]	PUNCT
dpc-539	96	26	.	.	PUNCT
dpc-539	97	1	another	another	DET
dpc-539	97	2	meta	meta	ADJ
dpc-539	97	3	-	-	PUNCT
dpc-539	97	4	analysis	analysis	NOUN
dpc-539	97	5	of	of	ADP
dpc-539	97	6	braf	braf	NOUN
dpc-539	97	7	mutations	mutation	NOUN
dpc-539	97	8	and	and	CCONJ
dpc-539	97	9	their	their	PRON
dpc-539	97	10	associations	association	NOUN
dpc-539	97	11	with	with	ADP
dpc-539	97	12	the	the	DET
dpc-539	97	13	clinicopathological	clinicopathological	ADJ
dpc-539	97	14	characteristics	characteristic	NOUN
dpc-539	97	15	of	of	ADP
dpc-539	97	16	primary	primary	ADJ
dpc-539	97	17	mm	mm	PROPN
dpc-539	97	18	showed	show	VERB
dpc-539	97	19	an	an	DET
dpc-539	97	20	association	association	NOUN
dpc-539	97	21	of	of	ADP
dpc-539	97	22	braf	braf	NOUN
dpc-539	97	23	mutations	mutation	NOUN
dpc-539	97	24	with	with	ADP
dpc-539	97	25	younger	young	ADJ
dpc-539	97	26	age	age	NOUN
dpc-539	97	27	,	,	PUNCT
dpc-539	97	28	location	location	NOUN
dpc-539	97	29	at	at	ADP
dpc-539	97	30	the	the	DET
dpc-539	97	31	torso	torso	NOUN
dpc-539	97	32	,	,	PUNCT
dpc-539	97	33	non	non	ADJ
dpc-539	97	34	–	–	PUNCT
dpc-539	97	35	chronically	chronically	ADV
dpc-539	97	36	sun	sun	NOUN
dpc-539	97	37	-	-	PUNCT
dpc-539	97	38	damaged	damage	VERB
dpc-539	97	39	skin	skin	NOUN
dpc-539	97	40	,	,	PUNCT
dpc-539	97	41	ssm	ssm	PROPN
dpc-539	97	42	type	type	NOUN
dpc-539	97	43	,	,	PUNCT
dpc-539	97	44	and	and	CCONJ
dpc-539	97	45	advanced	advanced	ADJ
dpc-539	97	46	melanoma	melanoma	NOUN
dpc-539	97	47	stage	stage	NOUN
dpc-539	97	48	[	[	X
dpc-539	97	49	16	16	NUM
dpc-539	97	50	]	]	PUNCT
dpc-539	97	51	.	.	PUNCT
dpc-539	98	1	similar	similar	ADJ
dpc-539	98	2	results	result	NOUN
dpc-539	98	3	were	be	AUX
dpc-539	98	4	identified	identify	VERB
dpc-539	98	5	in	in	ADP
dpc-539	98	6	our	our	PRON
dpc-539	98	7	sample	sample	NOUN
dpc-539	98	8	set	set	NOUN
dpc-539	98	9	,	,	PUNCT
dpc-539	98	10	but	but	CCONJ
dpc-539	98	11	after	after	ADP
dpc-539	98	12	using	use	VERB
dpc-539	98	13	a	a	DET
dpc-539	98	14	logistic	logistic	ADJ
dpc-539	98	15	regression	regression	NOUN
dpc-539	98	16	model	model	NOUN
dpc-539	98	17	,	,	PUNCT
dpc-539	98	18	only	only	ADV
dpc-539	98	19	ulceration	ulceration	NOUN
dpc-539	98	20	and	and	CCONJ
dpc-539	98	21	melanoma	melanoma	NOUN
dpc-539	98	22	type	type	NOUN
dpc-539	98	23	were	be	AUX
dpc-539	98	24	significant	significant	ADJ
dpc-539	98	25	predictors	predictor	NOUN
dpc-539	98	26	.	.	PUNCT
dpc-539	99	1	in	in	ADP
dpc-539	99	2	agreement	agreement	NOUN
dpc-539	99	3	with	with	ADP
dpc-539	99	4	previous	previous	ADJ
dpc-539	99	5	studies	study	NOUN
dpc-539	99	6	,	,	PUNCT
dpc-539	99	7	braf	braf	NOUN
dpc-539	99	8	mutations	mutation	NOUN
dpc-539	99	9	were	be	AUX
dpc-539	99	10	more	more	ADV
dpc-539	99	11	commonly	commonly	ADV
dpc-539	99	12	found	find	VERB
dpc-539	99	13	in	in	ADP
dpc-539	99	14	ssm	ssm	PROPN
dpc-539	99	15	,	,	PUNCT
dpc-539	99	16	and	and	CCONJ
dpc-539	99	17	with	with	ADP
dpc-539	99	18	decreasing	decrease	VERB
dpc-539	99	19	frequency	frequency	NOUN
dpc-539	99	20	in	in	ADP
dpc-539	99	21	nm	nm	PROPN
dpc-539	99	22	,	,	PUNCT
dpc-539	99	23	alm	alm	PROPN
dpc-539	99	24	,	,	PUNCT
dpc-539	99	25	and	and	CCONJ
dpc-539	99	26	lmm	lmm	PROPN
dpc-539	100	1	[	[	X
dpc-539	100	2	12	12	NUM
dpc-539	100	3	,	,	PUNCT
dpc-539	100	4	13	13	NUM
dpc-539	100	5	,	,	PUNCT
dpc-539	100	6	16	16	NUM
dpc-539	100	7	,	,	PUNCT
dpc-539	100	8	17	17	NUM
dpc-539	100	9	]	]	PUNCT
dpc-539	100	10	.	.	PUNCT
dpc-539	101	1	as	as	SCONJ
dpc-539	101	2	expected	expect	VERB
dpc-539	101	3	,	,	PUNCT
dpc-539	101	4	intraepidermal	intraepidermal	ADJ
dpc-539	101	5	(	(	PUNCT
dpc-539	101	6	in	in	ADP
dpc-539	101	7	situ	situ	NOUN
dpc-539	101	8	)	)	PUNCT
dpc-539	101	9	mms	mms	NOUN
dpc-539	101	10	had	have	VERB
dpc-539	101	11	an	an	DET
dpc-539	101	12	intermediate	intermediate	ADJ
dpc-539	101	13	braf	braf	NOUN
dpc-539	101	14	mutation	mutation	NOUN
dpc-539	101	15	frequency	frequency	NOUN
dpc-539	101	16	.	.	PUNCT
dpc-539	102	1	upon	upon	SCONJ
dpc-539	102	2	further	further	ADJ
dpc-539	102	3	analysis	analysis	NOUN
dpc-539	102	4	,	,	PUNCT
dpc-539	102	5	we	we	PRON
dpc-539	102	6	identified	identify	VERB
dpc-539	102	7	that	that	SCONJ
dpc-539	102	8	ulcerated	ulcerated	ADJ
dpc-539	102	9	nms	nms	PROPN
dpc-539	102	10	had	have	VERB
dpc-539	102	11	a	a	DET
dpc-539	102	12	braf	braf	NOUN
dpc-539	102	13	mutation	mutation	NOUN
dpc-539	102	14	frequency	frequency	NOUN
dpc-539	102	15	similar	similar	ADJ
dpc-539	102	16	to	to	ADP
dpc-539	102	17	ssms	ssm	NOUN
dpc-539	102	18	(	(	PUNCT
dpc-539	102	19	56.4	56.4	NUM
dpc-539	102	20	%	%	NOUN
dpc-539	102	21	)	)	PUNCT
dpc-539	102	22	,	,	PUNCT
dpc-539	102	23	whereas	whereas	SCONJ
dpc-539	102	24	non	non	ADJ
dpc-539	102	25	-	-	ADJ
dpc-539	102	26	ulcerated	ulcerated	ADJ
dpc-539	102	27	nms	nms	NOUN
dpc-539	102	28	had	have	VERB
dpc-539	102	29	a	a	DET
dpc-539	102	30	percentage	percentage	NOUN
dpc-539	102	31	more	more	ADV
dpc-539	102	32	akin	akin	ADJ
dpc-539	102	33	to	to	ADP
dpc-539	102	34	that	that	PRON
dpc-539	102	35	of	of	ADP
dpc-539	102	36	the	the	DET
dpc-539	102	37	alm	alm	PROPN
dpc-539	102	38	/	/	SYM
dpc-539	102	39	lmm	lmm	PROPN
dpc-539	102	40	group	group	NOUN
dpc-539	102	41	(	(	PUNCT
dpc-539	102	42	14.3	14.3	NUM
dpc-539	102	43	%	%	NOUN
dpc-539	102	44	)	)	PUNCT
dpc-539	102	45	.	.	PUNCT
dpc-539	103	1	this	this	PRON
dpc-539	103	2	could	could	AUX
dpc-539	103	3	be	be	AUX
dpc-539	103	4	explained	explain	VERB
dpc-539	103	5	if	if	SCONJ
dpc-539	103	6	one	one	PRON
dpc-539	103	7	considers	consider	VERB
dpc-539	103	8	ulcerated	ulcerated	ADJ
dpc-539	103	9	nms	nms	NOUN
dpc-539	103	10	as	as	ADP
dpc-539	103	11	rapidly	rapidly	ADV
dpc-539	103	12	growing	grow	VERB
dpc-539	103	13	ex	ex	NOUN
dpc-539	103	14	-	-	NOUN
dpc-539	103	15	ssms	ssm	NOUN
dpc-539	103	16	,	,	PUNCT
dpc-539	103	17	whose	whose	DET
dpc-539	103	18	adjacent	adjacent	ADJ
dpc-539	103	19	intraepidermal	intraepidermal	ADJ
dpc-539	103	20	component	component	NOUN
dpc-539	103	21	was	be	AUX
dpc-539	103	22	phased	phase	VERB
dpc-539	103	23	out	out	ADP
dpc-539	104	1	[	[	X
dpc-539	104	2	18	18	NUM
dpc-539	104	3	]	]	PUNCT
dpc-539	104	4	.	.	PUNCT
dpc-539	105	1	another	another	DET
dpc-539	105	2	histopathological	histopathological	ADJ
dpc-539	105	3	parameter	parameter	NOUN
dpc-539	105	4	significantly	significantly	ADV
dpc-539	105	5	related	relate	VERB
dpc-539	105	6	to	to	ADP
dpc-539	105	7	braf	braf	NOUN
dpc-539	105	8	mutations	mutation	NOUN
dpc-539	105	9	was	be	AUX
dpc-539	105	10	ulceration	ulceration	NOUN
dpc-539	105	11	.	.	PUNCT
dpc-539	106	1	some	some	DET
dpc-539	106	2	studies	study	NOUN
dpc-539	106	3	have	have	AUX
dpc-539	106	4	also	also	ADV
dpc-539	106	5	reported	report	VERB
dpc-539	106	6	increased	increase	VERB
dpc-539	106	7	braf	braf	NOUN
dpc-539	106	8	mutation	mutation	NOUN
dpc-539	106	9	percentage	percentage	NOUN
dpc-539	106	10	in	in	ADP
dpc-539	106	11	ulcerated	ulcerated	ADJ
dpc-539	106	12	samples	sample	NOUN
dpc-539	106	13	[	[	X
dpc-539	106	14	12	12	NUM
dpc-539	106	15	,	,	PUNCT
dpc-539	106	16	17	17	NUM
dpc-539	106	17	,	,	PUNCT
dpc-539	106	18	19	19	NUM
dpc-539	106	19	-	-	SYM
dpc-539	106	20	21	21	NUM
dpc-539	106	21	]	]	PUNCT
dpc-539	106	22	,	,	PUNCT
dpc-539	106	23	while	while	SCONJ
dpc-539	106	24	others	other	NOUN
dpc-539	106	25	,	,	PUNCT
dpc-539	106	26	including	include	VERB
dpc-539	106	27	a	a	DET
dpc-539	106	28	meta	meta	ADJ
dpc-539	106	29	-	-	PUNCT
dpc-539	106	30	analysis	analysis	NOUN
dpc-539	106	31	,	,	PUNCT
dpc-539	106	32	did	do	AUX
dpc-539	106	33	not	not	PART
dpc-539	106	34	[	[	X
dpc-539	106	35	13	13	NUM
dpc-539	106	36	,	,	PUNCT
dpc-539	106	37	16	16	NUM
dpc-539	106	38	]	]	PUNCT
dpc-539	106	39	.	.	PUNCT
dpc-539	107	1	the	the	DET
dpc-539	107	2	2	2	NUM
dpc-539	107	3	studies	study	NOUN
dpc-539	107	4	that	that	PRON
dpc-539	107	5	included	include	VERB
dpc-539	107	6	only	only	ADV
dpc-539	107	7	1	1	NUM
dpc-539	107	8	type	type	NOUN
dpc-539	107	9	from	from	ADP
dpc-539	107	10	a	a	DET
dpc-539	107	11	slight	slight	ADJ
dpc-539	107	12	increase	increase	NOUN
dpc-539	107	13	in	in	ADP
dpc-539	107	14	braf	braf	NOUN
dpc-539	107	15	mutations	mutation	NOUN
dpc-539	107	16	among	among	ADP
dpc-539	107	17	cases	case	NOUN
dpc-539	107	18	with	with	ADP
dpc-539	107	19	tils	til	NOUN
dpc-539	107	20	(	(	PUNCT
dpc-539	107	21	42.9	42.9	NUM
dpc-539	107	22	%	%	NOUN
dpc-539	107	23	vs	vs	ADP
dpc-539	107	24	37.5	37.5	NUM
dpc-539	107	25	%	%	NOUN
dpc-539	107	26	,	,	PUNCT
dpc-539	107	27	fisher	fisher	PROPN
dpc-539	107	28	exact	exact	ADJ
dpc-539	107	29	test	test	NOUN
dpc-539	107	30	)	)	PUNCT
dpc-539	107	31	or	or	CCONJ
dpc-539	107	32	mms	mms	NOUN
dpc-539	107	33	with	with	ADP
dpc-539	107	34	breslow	breslow	ADJ
dpc-539	107	35	thickness	thickness	NOUN
dpc-539	107	36	>	>	X
dpc-539	107	37	1	1	NUM
dpc-539	107	38	mm	mm	NOUN
dpc-539	107	39	(	(	PUNCT
dpc-539	107	40	43.9	43.9	NUM
dpc-539	107	41	%	%	NOUN
dpc-539	107	42	vs	vs	ADP
dpc-539	107	43	38.1	38.1	NUM
dpc-539	107	44	%	%	NOUN
dpc-539	107	45	,	,	PUNCT
dpc-539	107	46	fisher	fisher	PROPN
dpc-539	107	47	exact	exact	ADJ
dpc-539	107	48	test	test	NOUN
dpc-539	107	49	)	)	PUNCT
dpc-539	107	50	.	.	PUNCT
dpc-539	108	1	concerning	concern	VERB
dpc-539	108	2	the	the	DET
dpc-539	108	3	type	type	NOUN
dpc-539	108	4	of	of	ADP
dpc-539	108	5	mm	mm	PROPN
dpc-539	108	6	,	,	PUNCT
dpc-539	108	7	mutations	mutation	NOUN
dpc-539	108	8	were	be	AUX
dpc-539	108	9	more	more	ADV
dpc-539	108	10	common	common	ADJ
dpc-539	108	11	in	in	ADP
dpc-539	108	12	superficial	superficial	ADJ
dpc-539	108	13	spreading	spread	VERB
dpc-539	108	14	mm	mm	PROPN
dpc-539	108	15	(	(	PUNCT
dpc-539	108	16	ssm	ssm	PROPN
dpc-539	108	17	)	)	PUNCT
dpc-539	108	18	and	and	CCONJ
dpc-539	108	19	nodular	nodular	ADJ
dpc-539	108	20	mm	mm	PROPN
dpc-539	108	21	(	(	PUNCT
dpc-539	108	22	nm	nm	NOUN
dpc-539	108	23	)	)	PUNCT
dpc-539	108	24	and	and	CCONJ
dpc-539	108	25	less	less	ADV
dpc-539	108	26	common	common	ADJ
dpc-539	108	27	in	in	ADP
dpc-539	108	28	acral	acral	ADJ
dpc-539	108	29	lentiginous	lentiginous	ADJ
dpc-539	108	30	mm	mm	PROPN
dpc-539	108	31	(	(	PUNCT
dpc-539	108	32	alm	alm	PROPN
dpc-539	108	33	)	)	PUNCT
dpc-539	108	34	and	and	CCONJ
dpc-539	108	35	lentigo	lentigo	ADJ
dpc-539	108	36	maligna	maligna	PROPN
dpc-539	108	37	melanomas	melanomas	PROPN
dpc-539	108	38	(	(	PUNCT
dpc-539	108	39	lmm	lmm	PROPN
dpc-539	108	40	)	)	PUNCT
dpc-539	108	41	.	.	PUNCT
dpc-539	109	1	primary	primary	ADJ
dpc-539	109	2	dermal	dermal	NOUN
dpc-539	109	3	mm	mm	NOUN
dpc-539	109	4	and	and	CCONJ
dpc-539	109	5	intraepidermal	intraepidermal	ADJ
dpc-539	109	6	(	(	PUNCT
dpc-539	109	7	in	in	ADP
dpc-539	109	8	situ	situ	NOUN
dpc-539	109	9	)	)	PUNCT
dpc-539	109	10	melanomas	melanoma	NOUN
dpc-539	109	11	displayed	display	VERB
dpc-539	109	12	an	an	DET
dpc-539	109	13	intermediate	intermediate	ADJ
dpc-539	109	14	frequency	frequency	NOUN
dpc-539	109	15	.	.	PUNCT
dpc-539	110	1	the	the	DET
dpc-539	110	2	trend	trend	NOUN
dpc-539	110	3	was	be	AUX
dpc-539	110	4	significant	significant	ADJ
dpc-539	110	5	when	when	SCONJ
dpc-539	110	6	analyzing	analyze	VERB
dpc-539	110	7	the	the	DET
dpc-539	110	8	different	different	ADJ
dpc-539	110	9	types	type	NOUN
dpc-539	110	10	,	,	PUNCT
dpc-539	110	11	whether	whether	SCONJ
dpc-539	110	12	primary	primary	ADJ
dpc-539	110	13	dermal	dermal	NOUN
dpc-539	110	14	and	and	CCONJ
dpc-539	110	15	in	in	ADP
dpc-539	110	16	situ	situ	ADJ
dpc-539	110	17	melanomas	melanomas	NOUN
dpc-539	110	18	were	be	AUX
dpc-539	110	19	included	include	VERB
dpc-539	110	20	in	in	ADP
dpc-539	110	21	the	the	DET
dpc-539	110	22	analysis	analysis	NOUN
dpc-539	110	23	or	or	CCONJ
dpc-539	110	24	not	not	PART
dpc-539	110	25	.	.	PUNCT
dpc-539	111	1	cross	cross	NOUN
dpc-539	111	2	-	-	NOUN
dpc-539	111	3	tabulation	tabulation	NOUN
dpc-539	111	4	of	of	ADP
dpc-539	111	5	melanoma	melanoma	NOUN
dpc-539	111	6	types	type	NOUN
dpc-539	111	7	with	with	ADP
dpc-539	111	8	braf	braf	NOUN
dpc-539	111	9	status	status	NOUN
dpc-539	111	10	divided	divide	VERB
dpc-539	111	11	by	by	ADP
dpc-539	111	12	presence	presence	NOUN
dpc-539	111	13	of	of	ADP
dpc-539	111	14	ulceration	ulceration	NOUN
dpc-539	111	15	showed	show	VERB
dpc-539	111	16	similar	similar	ADJ
dpc-539	111	17	mutated	mutate	VERB
dpc-539	111	18	samples	sample	NOUN
dpc-539	111	19	with	with	ADP
dpc-539	111	20	or	or	CCONJ
dpc-539	111	21	without	without	ADP
dpc-539	111	22	ulceration	ulceration	NOUN
dpc-539	111	23	for	for	ADP
dpc-539	111	24	alm	alm	NOUN
dpc-539	111	25	(	(	PUNCT
dpc-539	111	26	1/4	1/4	NUM
dpc-539	111	27	vs	vs	ADP
dpc-539	111	28	0/4	0/4	NUM
dpc-539	111	29	)	)	PUNCT
dpc-539	111	30	,	,	PUNCT
dpc-539	111	31	lmm	lmm	PROPN
dpc-539	111	32	(	(	PUNCT
dpc-539	111	33	1/5	1/5	NUM
dpc-539	111	34	vs	vs	ADP
dpc-539	111	35	1/7	1/7	NUM
dpc-539	111	36	)	)	PUNCT
dpc-539	111	37	,	,	PUNCT
dpc-539	111	38	and	and	CCONJ
dpc-539	111	39	smm	smm	X
dpc-539	111	40	(	(	PUNCT
dpc-539	111	41	10/16	10/16	NUM
dpc-539	111	42	vs	vs	ADP
dpc-539	111	43	13/27	13/27	NUM
dpc-539	111	44	)	)	PUNCT
dpc-539	111	45	,	,	PUNCT
dpc-539	111	46	but	but	CCONJ
dpc-539	111	47	not	not	PART
dpc-539	111	48	for	for	ADP
dpc-539	111	49	nm	nm	PRON
dpc-539	111	50	(	(	PUNCT
dpc-539	111	51	2/14	2/14	NUM
dpc-539	111	52	vs	vs	ADP
dpc-539	111	53	18/32	18/32	NUM
dpc-539	111	54	,	,	PUNCT
dpc-539	111	55	14.3	14.3	NUM
dpc-539	111	56	%	%	NOUN
dpc-539	111	57	vs	vs	ADP
dpc-539	111	58	56.2	56.2	NUM
dpc-539	111	59	%	%	NOUN
dpc-539	111	60	,	,	PUNCT
dpc-539	111	61	p	p	X
dpc-539	111	62	=	=	NOUN
dpc-539	111	63	0.010	0.010	NUM
dpc-539	111	64	,	,	PUNCT
dpc-539	111	65	fisher	fisher	PROPN
dpc-539	111	66	exact	exact	ADJ
dpc-539	111	67	test	test	NOUN
dpc-539	111	68	)	)	PUNCT
dpc-539	111	69	.	.	PUNCT
dpc-539	112	1	we	we	PRON
dpc-539	112	2	then	then	ADV
dpc-539	112	3	used	use	VERB
dpc-539	112	4	a	a	DET
dpc-539	112	5	backward	backward	ADJ
dpc-539	112	6	step	step	NOUN
dpc-539	112	7	-	-	PUNCT
dpc-539	112	8	wise	wise	ADJ
dpc-539	112	9	wald	wald	ADJ
dpc-539	112	10	binary	binary	PROPN
dpc-539	112	11	logistic	logistic	PROPN
dpc-539	112	12	regression	regression	NOUN
dpc-539	112	13	analysis	analysis	NOUN
dpc-539	112	14	including	include	VERB
dpc-539	112	15	all	all	DET
dpc-539	112	16	borderline	borderline	NOUN
dpc-539	112	17	and	and	CCONJ
dpc-539	112	18	statistically	statistically	ADV
dpc-539	112	19	significant	significant	ADJ
dpc-539	112	20	parameters	parameter	NOUN
dpc-539	112	21	.	.	PUNCT
dpc-539	113	1	topology	topology	NOUN
dpc-539	113	2	and	and	CCONJ
dpc-539	113	3	age	age	NOUN
dpc-539	113	4	were	be	AUX
dpc-539	113	5	removed	remove	VERB
dpc-539	113	6	during	during	ADP
dpc-539	113	7	model	model	NOUN
dpc-539	113	8	creation	creation	NOUN
dpc-539	113	9	,	,	PUNCT
dpc-539	113	10	while	while	SCONJ
dpc-539	113	11	ulceration	ulceration	NOUN
dpc-539	113	12	(	(	PUNCT
dpc-539	113	13	p	p	X
dpc-539	113	14	=	=	NOUN
dpc-539	113	15	0.008	0.008	NUM
dpc-539	113	16	,	,	PUNCT
dpc-539	113	17	odds	odd	NOUN
dpc-539	113	18	ratio	ratio	NOUN
dpc-539	113	19	=	=	SYM
dpc-539	113	20	3.509	3.509	NUM
dpc-539	113	21	)	)	PUNCT
dpc-539	113	22	and	and	CCONJ
dpc-539	113	23	type	type	NOUN
dpc-539	113	24	(	(	PUNCT
dpc-539	113	25	p	p	NOUN
dpc-539	113	26	=	=	NOUN
dpc-539	113	27	0.024	0.024	NUM
dpc-539	113	28	)	)	PUNCT
dpc-539	113	29	,	,	PUNCT
dpc-539	113	30	specifically	specifically	ADV
dpc-539	113	31	ssm	ssm	PROPN
dpc-539	113	32	type	type	NOUN
dpc-539	113	33	(	(	PUNCT
dpc-539	113	34	p	p	X
dpc-539	113	35	=	=	NOUN
dpc-539	113	36	0.020	0.020	NUM
dpc-539	113	37	,	,	PUNCT
dpc-539	113	38	odds	odd	NOUN
dpc-539	113	39	ratio	ratio	NOUN
dpc-539	113	40	=	=	SYM
dpc-539	113	41	7.626	7.626	NUM
dpc-539	113	42	)	)	PUNCT
dpc-539	113	43	,	,	PUNCT
dpc-539	113	44	were	be	AUX
dpc-539	113	45	the	the	DET
dpc-539	113	46	only	only	ADJ
dpc-539	113	47	predictors	predictor	NOUN
dpc-539	113	48	.	.	PUNCT
dpc-539	114	1	discussion	discussion	NOUN
dpc-539	114	2	per	per	ADP
dpc-539	114	3	our	our	PRON
dpc-539	114	4	results	result	NOUN
dpc-539	114	5	,	,	PUNCT
dpc-539	114	6	a	a	DET
dpc-539	114	7	42.1	42.1	NUM
dpc-539	114	8	%	%	NOUN
dpc-539	114	9	prevalence	prevalence	NOUN
dpc-539	114	10	of	of	ADP
dpc-539	114	11	braf	braf	NOUN
dpc-539	114	12	mutations	mutation	NOUN
dpc-539	114	13	at	at	ADP
dpc-539	114	14	codon	codon	NOUN
dpc-539	114	15	600	600	NUM
dpc-539	114	16	among	among	ADP
dpc-539	114	17	our	our	PRON
dpc-539	114	18	patients	patient	NOUN
dpc-539	114	19	with	with	ADP
dpc-539	114	20	mm	mm	PROPN
dpc-539	114	21	was	be	AUX
dpc-539	114	22	observed	observe	VERB
dpc-539	114	23	.	.	PUNCT
dpc-539	115	1	these	these	DET
dpc-539	115	2	mutations	mutation	NOUN
dpc-539	115	3	were	be	AUX
dpc-539	115	4	statistically	statistically	ADV
dpc-539	115	5	more	more	ADV
dpc-539	115	6	common	common	ADJ
dpc-539	115	7	in	in	ADP
dpc-539	115	8	younger	young	ADJ
dpc-539	115	9	patients	patient	NOUN
dpc-539	115	10	,	,	PUNCT
dpc-539	115	11	in	in	ADP
dpc-539	115	12	ulcerated	ulcerated	ADJ
dpc-539	115	13	mms	mms	NOUN
dpc-539	115	14	,	,	PUNCT
dpc-539	115	15	and	and	CCONJ
dpc-539	115	16	in	in	ADP
dpc-539	115	17	mms	mms	NOUN
dpc-539	115	18	lacking	lack	VERB
dpc-539	115	19	solar	solar	ADJ
dpc-539	115	20	elastosis	elastosis	NOUN
dpc-539	115	21	in	in	ADP
dpc-539	115	22	adjacent	adjacent	ADJ
dpc-539	115	23	papillary	papillary	ADJ
dpc-539	115	24	dermis	dermis	NOUN
dpc-539	115	25	.	.	PUNCT
dpc-539	116	1	these	these	DET
dpc-539	116	2	findings	finding	NOUN
dpc-539	116	3	are	be	AUX
dpc-539	116	4	consistent	consistent	ADJ
dpc-539	116	5	with	with	ADP
dpc-539	116	6	previous	previous	ADJ
dpc-539	116	7	experience	experience	NOUN
dpc-539	116	8	[	[	X
dpc-539	116	9	7	7	NUM
dpc-539	116	10	,	,	PUNCT
dpc-539	116	11	12	12	NUM
dpc-539	116	12	]	]	PUNCT
dpc-539	116	13	.	.	PUNCT
dpc-539	117	1	a	a	DET
dpc-539	117	2	trend	trend	NOUN
dpc-539	117	3	for	for	ADP
dpc-539	117	4	increased	increase	VERB
dpc-539	117	5	percentage	percentage	NOUN
dpc-539	117	6	of	of	ADP
dpc-539	117	7	braf	braf	NOUN
dpc-539	117	8	mutations	mutation	NOUN
dpc-539	117	9	was	be	AUX
dpc-539	117	10	documented	document	VERB
dpc-539	117	11	in	in	ADP
dpc-539	117	12	men	man	NOUN
dpc-539	117	13	with	with	ADP
dpc-539	117	14	mms	mms	NOUN
dpc-539	117	15	of	of	ADP
dpc-539	117	16	the	the	DET
dpc-539	117	17	torso	torso	NOUN
dpc-539	117	18	,	,	PUNCT
dpc-539	117	19	in	in	ADP
dpc-539	117	20	mms	mms	NOUN
dpc-539	117	21	more	more	ADJ
dpc-539	117	22	than	than	ADP
dpc-539	117	23	1	1	NUM
dpc-539	117	24	mm	mm	NOUN
dpc-539	117	25	breslow	breslow	NOUN
dpc-539	117	26	thickness	thickness	NOUN
dpc-539	117	27	,	,	PUNCT
dpc-539	117	28	higher	high	ADJ
dpc-539	117	29	mitotic	mitotic	ADJ
dpc-539	117	30	rate	rate	NOUN
dpc-539	117	31	,	,	PUNCT
dpc-539	117	32	reported	report	VERB
dpc-539	117	33	metastasis	metastasis	NOUN
dpc-539	117	34	,	,	PUNCT
dpc-539	117	35	and	and	CCONJ
dpc-539	117	36	earlier	early	ADV
dpc-539	117	37	reported	report	VERB
dpc-539	117	38	recurrences	recurrence	NOUN
dpc-539	117	39	.	.	PUNCT
dpc-539	118	1	however	however	ADV
dpc-539	118	2	,	,	PUNCT
dpc-539	118	3	these	these	DET
dpc-539	118	4	findings	finding	NOUN
dpc-539	118	5	did	do	AUX
dpc-539	118	6	not	not	PART
dpc-539	118	7	reach	reach	VERB
dpc-539	118	8	statistical	statistical	ADJ
dpc-539	118	9	table	table	NOUN
dpc-539	118	10	3	3	NUM
dpc-539	118	11	.	.	PUNCT
dpc-539	118	12	patient	patient	ADJ
dpc-539	118	13	characteristics	characteristic	NOUN
dpc-539	118	14	of	of	ADP
dpc-539	118	15	metastatic	metastatic	ADJ
dpc-539	118	16	melanomas	melanoma	NOUN
dpc-539	118	17	and	and	CCONJ
dpc-539	118	18	braf	braf	NOUN
dpc-539	118	19	status	status	NOUN
dpc-539	118	20	braf	braf	NOUN
dpc-539	118	21	status	status	NOUN
dpc-539	118	22	total	total	NOUN
dpc-539	118	23	mutated	mutate	VERB
dpc-539	118	24	(	(	PUNCT
dpc-539	118	25	%	%	INTJ
dpc-539	118	26	)	)	PUNCT
dpc-539	119	1	p	p	NOUN
dpc-539	119	2	wt	wt	ADP
dpc-539	119	3	mutated	mutate	VERB
dpc-539	119	4	age	age	NOUN
dpc-539	119	5	,	,	PUNCT
dpc-539	119	6	mean	mean	NOUN
dpc-539	119	7	(	(	PUNCT
dpc-539	119	8	95	95	NUM
dpc-539	119	9	%	%	NOUN
dpc-539	119	10	ci	ci	NOUN
dpc-539	119	11	)	)	PUNCT
dpc-539	119	12	(	(	PUNCT
dpc-539	119	13	n	n	NOUN
dpc-539	119	14	=	=	SYM
dpc-539	119	15	56	56	NUM
dpc-539	119	16	)	)	PUNCT
dpc-539	119	17	61.5	61.5	NUM
dpc-539	119	18	(	(	PUNCT
dpc-539	119	19	55.3	55.3	NUM
dpc-539	119	20	-	-	SYM
dpc-539	119	21	67.7	67.7	NUM
dpc-539	119	22	)	)	PUNCT
dpc-539	119	23	57.7	57.7	NUM
dpc-539	119	24	(	(	PUNCT
dpc-539	119	25	51.9	51.9	NUM
dpc-539	119	26	-	-	SYM
dpc-539	119	27	63.5	63.5	NUM
dpc-539	119	28	)	)	PUNCT
dpc-539	119	29	59.7	59.7	NUM
dpc-539	119	30	(	(	PUNCT
dpc-539	119	31	55.5	55.5	NUM
dpc-539	119	32	-	-	SYM
dpc-539	119	33	63.8	63.8	NUM
dpc-539	119	34	)	)	PUNCT
dpc-539	119	35	0.251	0.251	NUM
dpc-539	119	36	sex	sex	NOUN
dpc-539	119	37	(	(	PUNCT
dpc-539	119	38	n	n	NOUN
dpc-539	119	39	=	=	SYM
dpc-539	119	40	56	56	NUM
dpc-539	119	41	)	)	PUNCT
dpc-539	119	42	male	male	NOUN
dpc-539	119	43	14	14	NUM
dpc-539	119	44	21	21	NUM
dpc-539	119	45	35	35	NUM
dpc-539	119	46	60.0	60.0	NUM
dpc-539	119	47	0.029	0.029	NUM
dpc-539	119	48	female	female	ADJ
dpc-539	119	49	15	15	NUM
dpc-539	119	50	6	6	NUM
dpc-539	119	51	21	21	NUM
dpc-539	119	52	28.6	28.6	NUM
dpc-539	119	53	metastasis	metastasis	NOUN
dpc-539	119	54	site	site	NOUN
dpc-539	119	55	(	(	PUNCT
dpc-539	119	56	n	n	NOUN
dpc-539	119	57	=	=	SYM
dpc-539	119	58	56	56	NUM
dpc-539	119	59	)	)	PUNCT
dpc-539	119	60	distant	distant	ADJ
dpc-539	119	61	skin	skin	NOUN
dpc-539	119	62	or	or	CCONJ
dpc-539	119	63	ln	ln	NOUN
dpc-539	119	64	18	18	NUM
dpc-539	119	65	21	21	NUM
dpc-539	119	66	39	39	NUM
dpc-539	119	67	53.8	53.8	NUM
dpc-539	119	68	0.149	0.149	NUM
dpc-539	119	69	lung	lung	NOUN
dpc-539	119	70	0	0	NUM
dpc-539	119	71	1	1	NUM
dpc-539	119	72	1	1	NUM
dpc-539	119	73	100	100	NUM
dpc-539	119	74	other	other	ADJ
dpc-539	119	75	visceral	visceral	ADJ
dpc-539	119	76	11	11	NUM
dpc-539	119	77	5	5	NUM
dpc-539	119	78	16	16	NUM
dpc-539	119	79	31.3	31.3	NUM
dpc-539	119	80	ci	ci	NOUN
dpc-539	119	81	=	=	NOUN
dpc-539	119	82	confidence	confidence	NOUN
dpc-539	119	83	interval	interval	NOUN
dpc-539	119	84	;	;	PUNCT
dpc-539	119	85	ln	ln	NOUN
dpc-539	119	86	=	=	PUNCT
dpc-539	119	87	lymph	lymph	NOUN
dpc-539	119	88	node	node	NOUN
dpc-539	119	89	;	;	PUNCT
dpc-539	119	90	wt	wt	NOUN
dpc-539	119	91	=	=	PUNCT
dpc-539	119	92	wild	wild	ADJ
dpc-539	119	93	type	type	NOUN
dpc-539	119	94	research	research	NOUN
dpc-539	119	95	|	|	ADV
dpc-539	119	96	dermatol	dermatol	ADJ
dpc-539	119	97	pract	pract	NOUN
dpc-539	119	98	concept	concept	NOUN
dpc-539	119	99	2019;9(1):13	2019;9(1):13	NUM
dpc-539	119	100	61	61	NUM
dpc-539	119	101	ulceration	ulceration	NOUN
dpc-539	119	102	has	have	AUX
dpc-539	119	103	been	be	AUX
dpc-539	119	104	correlated	correlate	VERB
dpc-539	119	105	with	with	ADP
dpc-539	119	106	braf	braf	NOUN
dpc-539	119	107	mutations	mutation	NOUN
dpc-539	119	108	[	[	X
dpc-539	119	109	12	12	NUM
dpc-539	119	110	,	,	PUNCT
dpc-539	119	111	17	17	NUM
dpc-539	119	112	,	,	PUNCT
dpc-539	119	113	19	19	NUM
dpc-539	119	114	]	]	PUNCT
dpc-539	119	115	and	and	CCONJ
dpc-539	119	116	increased	increase	VERB
dpc-539	119	117	mitotic	mitotic	ADJ
dpc-539	119	118	rate	rate	NOUN
dpc-539	119	119	[	[	X
dpc-539	119	120	20	20	NUM
dpc-539	119	121	,	,	PUNCT
dpc-539	119	122	22	22	NUM
dpc-539	119	123	]	]	PUNCT
dpc-539	119	124	.	.	PUNCT
dpc-539	120	1	upon	upon	SCONJ
dpc-539	120	2	further	further	ADJ
dpc-539	120	3	analysis	analysis	NOUN
dpc-539	120	4	,	,	PUNCT
dpc-539	120	5	lower	low	ADJ
dpc-539	120	6	mitotic	mitotic	ADJ
dpc-539	120	7	rates	rate	NOUN
dpc-539	120	8	were	be	AUX
dpc-539	120	9	found	find	VERB
dpc-539	120	10	in	in	ADP
dpc-539	120	11	mutated	mutate	VERB
dpc-539	120	12	tumors	tumor	NOUN
dpc-539	120	13	compared	compare	VERB
dpc-539	120	14	with	with	ADP
dpc-539	120	15	wild	wild	ADJ
dpc-539	120	16	-	-	PUNCT
dpc-539	120	17	type	type	NOUN
dpc-539	120	18	ones	one	NOUN
dpc-539	120	19	(	(	PUNCT
dpc-539	120	20	2.2	2.2	NUM
dpc-539	120	21	vs	vs	ADP
dpc-539	120	22	6.83	6.83	NUM
dpc-539	120	23	)	)	PUNCT
dpc-539	120	24	in	in	ADP
dpc-539	120	25	alm	alm	PROPN
dpc-539	120	26	,	,	PUNCT
dpc-539	120	27	lmm	lmm	PROPN
dpc-539	120	28	,	,	PUNCT
dpc-539	120	29	and	and	CCONJ
dpc-539	120	30	nonulcerated	nonulcerate	VERB
dpc-539	120	31	nm	nm	PROPN
dpc-539	120	32	,	,	PUNCT
dpc-539	120	33	whereas	whereas	SCONJ
dpc-539	120	34	the	the	DET
dpc-539	120	35	contrary	contrary	NOUN
dpc-539	120	36	was	be	AUX
dpc-539	120	37	true	true	ADJ
dpc-539	120	38	concerning	concern	VERB
dpc-539	120	39	ulcerated	ulcerated	ADJ
dpc-539	120	40	nm	nm	PROPN
dpc-539	120	41	and	and	CCONJ
dpc-539	120	42	ssm	ssm	PROPN
dpc-539	120	43	(	(	PUNCT
dpc-539	120	44	6.80	6.80	NUM
dpc-539	120	45	vs	vs	ADP
dpc-539	120	46	4.82	4.82	NUM
dpc-539	120	47	)	)	PUNCT
dpc-539	120	48	.	.	PUNCT
dpc-539	121	1	of	of	ADP
dpc-539	121	2	melanoma	melanoma	PROPN
dpc-539	121	3	(	(	PUNCT
dpc-539	121	4	nm	nm	NOUN
dpc-539	121	5	)	)	PUNCT
dpc-539	121	6	identified	identify	VERB
dpc-539	121	7	a	a	DET
dpc-539	121	8	clear	clear	ADJ
dpc-539	121	9	correlation	correlation	NOUN
dpc-539	121	10	[	[	X
dpc-539	121	11	20	20	NUM
dpc-539	121	12	,	,	PUNCT
dpc-539	121	13	21	21	NUM
dpc-539	121	14	]	]	PUNCT
dpc-539	121	15	.	.	PUNCT
dpc-539	122	1	furthermore	furthermore	ADV
dpc-539	122	2	,	,	PUNCT
dpc-539	122	3	we	we	PRON
dpc-539	122	4	identified	identify	VERB
dpc-539	122	5	increased	increase	VERB
dpc-539	122	6	mitotic	mitotic	ADJ
dpc-539	122	7	rate	rate	NOUN
dpc-539	122	8	in	in	ADP
dpc-539	122	9	ulcerated	ulcerated	ADJ
dpc-539	122	10	melanomas	melanomas	NOUN
dpc-539	122	11	(	(	PUNCT
dpc-539	122	12	8.71	8.71	NUM
dpc-539	122	13	vs	vs	ADP
dpc-539	122	14	2.21	2.21	NUM
dpc-539	122	15	,	,	PUNCT
dpc-539	122	16	p	p	X
dpc-539	122	17	<	<	X
dpc-539	122	18	0.001	0.001	NUM
dpc-539	122	19	,	,	PUNCT
dpc-539	122	20	mann	mann	PROPN
dpc-539	122	21	-	-	PUNCT
dpc-539	122	22	whitney	whitney	PROPN
dpc-539	122	23	test	test	NOUN
dpc-539	122	24	)	)	PUNCT
dpc-539	122	25	,	,	PUNCT
dpc-539	122	26	yet	yet	CCONJ
dpc-539	122	27	no	no	DET
dpc-539	122	28	correlation	correlation	NOUN
dpc-539	122	29	between	between	ADP
dpc-539	122	30	an	an	DET
dpc-539	122	31	increased	increase	VERB
dpc-539	122	32	mitotic	mitotic	ADJ
dpc-539	122	33	rate	rate	NOUN
dpc-539	122	34	and	and	CCONJ
dpc-539	122	35	braf	braf	NOUN
dpc-539	122	36	mutation	mutation	NOUN
dpc-539	122	37	percentage	percentage	NOUN
dpc-539	122	38	was	be	AUX
dpc-539	122	39	identified	identify	VERB
dpc-539	122	40	(	(	PUNCT
dpc-539	122	41	4.8	4.8	NUM
dpc-539	122	42	vs	vs	ADP
dpc-539	122	43	5.6	5.6	NUM
dpc-539	122	44	,	,	PUNCT
dpc-539	122	45	p	p	X
dpc-539	122	46	=	=	NOUN
dpc-539	122	47	0.307	0.307	NUM
dpc-539	122	48	,	,	PUNCT
dpc-539	122	49	mann	mann	PROPN
dpc-539	122	50	-	-	PUNCT
dpc-539	122	51	whitney	whitney	PROPN
dpc-539	122	52	test	test	NOUN
dpc-539	122	53	)	)	PUNCT
dpc-539	122	54	.	.	PUNCT
dpc-539	123	1	this	this	PRON
dpc-539	123	2	seems	seem	VERB
dpc-539	123	3	contradictory	contradictory	ADJ
dpc-539	123	4	,	,	PUNCT
dpc-539	123	5	since	since	SCONJ
dpc-539	123	6	table	table	NOUN
dpc-539	123	7	4	4	NUM
dpc-539	123	8	.	.	PUNCT
dpc-539	124	1	histopathological	histopathological	ADJ
dpc-539	124	2	findings	finding	NOUN
dpc-539	124	3	and	and	CCONJ
dpc-539	124	4	braf	braf	NOUN
dpc-539	124	5	status	status	NOUN
dpc-539	124	6	of	of	ADP
dpc-539	124	7	primary	primary	ADJ
dpc-539	124	8	mm	mm	PROPN
dpc-539	124	9	braf	braf	NOUN
dpc-539	124	10	status	status	NOUN
dpc-539	124	11	total	total	NOUN
dpc-539	124	12	mutated	mutate	VERB
dpc-539	124	13	(	(	PUNCT
dpc-539	124	14	%	%	INTJ
dpc-539	124	15	)	)	PUNCT
dpc-539	124	16	p	p	NOUN
dpc-539	124	17	wt	wt	ADP
dpc-539	124	18	mutated	mutate	VERB
dpc-539	124	19	type	type	NOUN
dpc-539	124	20	(	(	PUNCT
dpc-539	124	21	n	n	NOUN
dpc-539	124	22	=	=	SYM
dpc-539	124	23	126	126	NUM
dpc-539	124	24	)	)	PUNCT
dpc-539	124	25	alm	alm	NOUN
dpc-539	124	26	7	7	NUM
dpc-539	124	27	1	1	NUM
dpc-539	124	28	8	8	NUM
dpc-539	124	29	12.5	12.5	NUM
dpc-539	124	30	0.004	0.004	NUM
dpc-539	124	31	lmm	lmm	PROPN
dpc-539	124	32	10	10	NUM
dpc-539	124	33	2	2	NUM
dpc-539	124	34	12	12	NUM
dpc-539	124	35	16.7	16.7	NUM
dpc-539	124	36	primary	primary	ADJ
dpc-539	124	37	dermal	dermal	NOUN
dpc-539	124	38	2	2	NUM
dpc-539	124	39	1	1	NUM
dpc-539	124	40	3	3	NUM
dpc-539	124	41	33.3	33.3	NUM
dpc-539	124	42	in	in	ADP
dpc-539	124	43	situ	situ	ADJ
dpc-539	124	44	9	9	NUM
dpc-539	124	45	5	5	NUM
dpc-539	124	46	14	14	NUM
dpc-539	124	47	35.7	35.7	NUM
dpc-539	124	48	nm	nm	NOUN
dpc-539	124	49	26	26	NUM
dpc-539	124	50	20	20	NUM
dpc-539	124	51	46	46	NUM
dpc-539	124	52	43.5	43.5	NUM
dpc-539	124	53	ssm	ssm	NOUN
dpc-539	124	54	20	20	NUM
dpc-539	124	55	23	23	NUM
dpc-539	124	56	43	43	NUM
dpc-539	124	57	53.5	53.5	NUM
dpc-539	124	58	clark	clark	NOUN
dpc-539	124	59	level	level	NOUN
dpc-539	124	60	(	(	PUNCT
dpc-539	124	61	n	n	NOUN
dpc-539	124	62	=	=	SYM
dpc-539	124	63	121	121	NUM
dpc-539	124	64	)	)	PUNCT
dpc-539	124	65	2.68	2.68	NUM
dpc-539	124	66	(	(	PUNCT
dpc-539	124	67	2.4	2.4	NUM
dpc-539	124	68	-	-	SYM
dpc-539	124	69	3.0	3.0	NUM
dpc-539	124	70	)	)	PUNCT
dpc-539	124	71	2.54	2.54	NUM
dpc-539	124	72	(	(	PUNCT
dpc-539	124	73	2.3	2.3	NUM
dpc-539	124	74	-	-	SYM
dpc-539	124	75	2.8	2.8	NUM
dpc-539	124	76	)	)	PUNCT
dpc-539	124	77	2.62	2.62	NUM
dpc-539	124	78	(	(	PUNCT
dpc-539	124	79	2.4	2.4	NUM
dpc-539	124	80	-	-	SYM
dpc-539	124	81	2.8	2.8	NUM
dpc-539	124	82	)	)	PUNCT
dpc-539	124	83	0.741	0.741	NUM
dpc-539	124	84	1	1	NUM
dpc-539	124	85	9	9	NUM
dpc-539	124	86	5	5	NUM
dpc-539	124	87	14	14	NUM
dpc-539	124	88	35.7	35.7	NUM
dpc-539	124	89	0.386	0.386	NUM
dpc-539	124	90	2	2	NUM
dpc-539	124	91	31	31	NUM
dpc-539	124	92	23	23	NUM
dpc-539	124	93	54	54	NUM
dpc-539	124	94	42.6	42.6	NUM
dpc-539	124	95	3	3	NUM
dpc-539	124	96	12	12	NUM
dpc-539	124	97	13	13	NUM
dpc-539	124	98	25	25	NUM
dpc-539	124	99	52.0	52.0	NUM
dpc-539	124	100	4	4	NUM
dpc-539	124	101	12	12	NUM
dpc-539	124	102	8	8	NUM
dpc-539	124	103	20	20	NUM
dpc-539	124	104	40.0	40.0	NUM
dpc-539	124	105	5	5	NUM
dpc-539	124	106	7	7	NUM
dpc-539	124	107	1	1	NUM
dpc-539	124	108	8	8	NUM
dpc-539	124	109	12.5	12.5	NUM
dpc-539	124	110	breslow	breslow	ADJ
dpc-539	124	111	thickness	thickness	NOUN
dpc-539	124	112	in	in	ADP
dpc-539	124	113	mm	mm	PROPN
dpc-539	124	114	,	,	PUNCT
dpc-539	124	115	(	(	PUNCT
dpc-539	124	116	n	n	NOUN
dpc-539	124	117	=	=	SYM
dpc-539	124	118	113	113	NUM
dpc-539	124	119	)	)	PUNCT
dpc-539	124	120	,	,	PUNCT
dpc-539	124	121	mean	mean	VERB
dpc-539	124	122	(	(	PUNCT
dpc-539	124	123	95	95	NUM
dpc-539	124	124	%	%	NOUN
dpc-539	124	125	ci	ci	NOUN
dpc-539	124	126	)	)	PUNCT
dpc-539	124	127	3.63	3.63	NUM
dpc-539	124	128	(	(	PUNCT
dpc-539	124	129	2.8	2.8	NUM
dpc-539	124	130	-	-	SYM
dpc-539	124	131	4.5	4.5	NUM
dpc-539	124	132	)	)	PUNCT
dpc-539	124	133	3.87	3.87	NUM
dpc-539	124	134	(	(	PUNCT
dpc-539	124	135	2.6	2.6	NUM
dpc-539	124	136	-	-	SYM
dpc-539	124	137	5.1	5.1	NUM
dpc-539	124	138	)	)	PUNCT
dpc-539	124	139	3.73	3.73	NUM
dpc-539	124	140	(	(	PUNCT
dpc-539	124	141	4.9	4.9	NUM
dpc-539	124	142	-	-	SYM
dpc-539	124	143	7.8	7.8	NUM
dpc-539	124	144	)	)	PUNCT
dpc-539	124	145	0.585	0.585	NUM
dpc-539	124	146	breslow	breslow	ADJ
dpc-539	124	147	thickness	thickness	NOUN
dpc-539	124	148	≤1	≤1	PROPN
dpc-539	124	149	mm	mm	PROPN
dpc-539	124	150	26	26	NUM
dpc-539	124	151	16	16	NUM
dpc-539	124	152	42	42	NUM
dpc-539	124	153	38.1	38.1	NUM
dpc-539	124	154	0.569	0.569	NUM
dpc-539	124	155	breslow	breslow	ADJ
dpc-539	124	156	thickness	thickness	NOUN
dpc-539	124	157	>	>	X
dpc-539	124	158	1	1	NUM
dpc-539	124	159	mm	mm	NUM
dpc-539	124	160	46	46	NUM
dpc-539	124	161	36	36	NUM
dpc-539	124	162	82	82	NUM
dpc-539	124	163	43.9	43.9	NUM
dpc-539	124	164	tis	tis	PROPN
dpc-539	124	165	10	10	NUM
dpc-539	124	166	6	6	NUM
dpc-539	124	167	16	16	NUM
dpc-539	124	168	37.5	37.5	NUM
dpc-539	124	169	0.828	0.828	NUM
dpc-539	124	170	t1	t1	NOUN
dpc-539	124	171	16	16	NUM
dpc-539	124	172	10	10	NUM
dpc-539	124	173	25	25	NUM
dpc-539	124	174	38.5	38.5	NUM
dpc-539	124	175	t2	t2	NOUN
dpc-539	124	176	9	9	NUM
dpc-539	124	177	8	8	NUM
dpc-539	124	178	17	17	NUM
dpc-539	124	179	47.1	47.1	NUM
dpc-539	124	180	t3	t3	NOUN
dpc-539	124	181	9	9	NUM
dpc-539	124	182	10	10	NUM
dpc-539	124	183	19	19	NUM
dpc-539	124	184	52.6	52.6	NUM
dpc-539	124	185	t4	t4	PROPN
dpc-539	124	186	28	28	NUM
dpc-539	124	187	18	18	NUM
dpc-539	124	188	46	46	NUM
dpc-539	124	189	39.1	39.1	NUM
dpc-539	124	190	tils	til	NOUN
dpc-539	124	191	(	(	PUNCT
dpc-539	124	192	n	n	NOUN
dpc-539	124	193	=	=	SYM
dpc-539	124	194	109	109	NUM
dpc-539	124	195	)	)	PUNCT
dpc-539	124	196	absent	absent	ADJ
dpc-539	124	197	20	20	NUM
dpc-539	124	198	12	12	NUM
dpc-539	124	199	32	32	NUM
dpc-539	124	200	37.5	37.5	NUM
dpc-539	124	201	0.875	0.875	NUM
dpc-539	124	202	nonbrisk	nonbrisk	NOUN
dpc-539	124	203	32	32	NUM
dpc-539	124	204	24	24	NUM
dpc-539	124	205	56	56	NUM
dpc-539	124	206	42.9	42.9	NUM
dpc-539	124	207	brisk	brisk	ADJ
dpc-539	124	208	12	12	NUM
dpc-539	124	209	9	9	NUM
dpc-539	124	210	21	21	NUM
dpc-539	124	211	42.9	42.9	NUM
dpc-539	124	212	mitoses	mitose	NOUN
dpc-539	124	213	(	(	PUNCT
dpc-539	124	214	n	n	NOUN
dpc-539	124	215	=	=	SYM
dpc-539	124	216	129	129	NUM
dpc-539	124	217	)	)	PUNCT
dpc-539	124	218	,	,	PUNCT
dpc-539	124	219	mean	mean	VERB
dpc-539	124	220	(	(	PUNCT
dpc-539	124	221	95	95	NUM
dpc-539	124	222	%	%	NOUN
dpc-539	124	223	ci	ci	NOUN
dpc-539	124	224	)	)	PUNCT
dpc-539	124	225	5.8	5.8	NUM
dpc-539	124	226	(	(	PUNCT
dpc-539	124	227	3.8	3.8	NUM
dpc-539	124	228	-	-	SYM
dpc-539	124	229	7.8	7.8	NUM
dpc-539	124	230	)	)	PUNCT
dpc-539	124	231	6.74	6.74	NUM
dpc-539	124	232	(	(	PUNCT
dpc-539	124	233	4.6	4.6	NUM
dpc-539	124	234	-	-	SYM
dpc-539	124	235	8.8	8.8	NUM
dpc-539	124	236	)	)	PUNCT
dpc-539	124	237	6.3	6.3	NUM
dpc-539	124	238	(	(	PUNCT
dpc-539	124	239	4.9	4.9	NUM
dpc-539	124	240	-	-	SYM
dpc-539	124	241	7.8	7.8	NUM
dpc-539	124	242	)	)	PUNCT
dpc-539	124	243	0.307	0.307	NUM
dpc-539	124	244	mitoses	mitose	VERB
dpc-539	124	245	<	<	X
dpc-539	124	246	1	1	NUM
dpc-539	124	247	/	/	SYM
dpc-539	124	248	mm2	mm2	NOUN
dpc-539	124	249	16	16	NUM
dpc-539	124	250	9	9	NUM
dpc-539	124	251	25	25	NUM
dpc-539	124	252	36.0	36.0	NUM
dpc-539	124	253	0.658	0.658	NUM
dpc-539	124	254	mitoses	mitose	NOUN
dpc-539	124	255	≥1	≥1	NUM
dpc-539	124	256	/	/	SYM
dpc-539	124	257	mm2	mm2	NOUN
dpc-539	124	258	61	61	NUM
dpc-539	124	259	43	43	NUM
dpc-539	124	260	104	104	NUM
dpc-539	124	261	41.3	41.3	NUM
dpc-539	124	262	ulceration	ulceration	NOUN
dpc-539	124	263	(	(	PUNCT
dpc-539	124	264	n	n	NOUN
dpc-539	124	265	=	=	SYM
dpc-539	124	266	129	129	NUM
dpc-539	124	267	)	)	PUNCT
dpc-539	124	268	no	no	DET
dpc-539	124	269	49	49	NUM
dpc-539	124	270	22	22	NUM
dpc-539	124	271	71	71	NUM
dpc-539	124	272	31.0	31.0	NUM
dpc-539	124	273	0.020	0.020	NUM
dpc-539	124	274	yes	yes	NOUN
dpc-539	125	1	28	28	NUM
dpc-539	125	2	30	30	NUM
dpc-539	125	3	58	58	NUM
dpc-539	125	4	51.7	51.7	NUM
dpc-539	125	5	solar	solar	ADJ
dpc-539	125	6	elastosis	elastosis	NOUN
dpc-539	125	7	(	(	PUNCT
dpc-539	125	8	n	n	NOUN
dpc-539	125	9	=	=	SYM
dpc-539	125	10	129	129	NUM
dpc-539	125	11	)	)	PUNCT
dpc-539	125	12	no	no	DET
dpc-539	125	13	64	64	NUM
dpc-539	125	14	51	51	NUM
dpc-539	125	15	115	115	NUM
dpc-539	125	16	44.3	44.3	NUM
dpc-539	125	17	0.008	0.008	NUM
dpc-539	125	18	yes	yes	NOUN
dpc-539	125	19	13	13	NUM
dpc-539	125	20	1	1	NUM
dpc-539	125	21	14	14	NUM
dpc-539	125	22	7.1	7.1	NUM
dpc-539	125	23	ci	ci	NOUN
dpc-539	125	24	=	=	NOUN
dpc-539	125	25	confidence	confidence	NOUN
dpc-539	125	26	interval	interval	NOUN
dpc-539	125	27	;	;	PUNCT
dpc-539	125	28	tis	tis	PROPN
dpc-539	125	29	=	=	PUNCT
dpc-539	125	30	tumor	tumor	NOUN
dpc-539	125	31	in	in	ADP
dpc-539	125	32	situ	situ	NOUN
dpc-539	125	33	;	;	PUNCT
dpc-539	125	34	wt	wt	NOUN
dpc-539	125	35	=	=	PUNCT
dpc-539	125	36	wild	wild	ADJ
dpc-539	125	37	type	type	NOUN
dpc-539	125	38	.	.	PUNCT
dpc-539	126	1	62	62	NUM
dpc-539	126	2	research	research	NOUN
dpc-539	126	3	|	|	ADV
dpc-539	126	4	dermatol	dermatol	NOUN
dpc-539	126	5	pract	pract	NOUN
dpc-539	126	6	concept	concept	NOUN
dpc-539	126	7	2019;9(1):13	2019;9(1):13	NUM
dpc-539	126	8	iiic	iiic	PROPN
dpc-539	126	9	melanoma	melanoma	NOUN
dpc-539	126	10	:	:	PUNCT
dpc-539	126	11	implications	implication	NOUN
dpc-539	126	12	for	for	ADP
dpc-539	126	13	melanoma	melanoma	NOUN
dpc-539	126	14	staging	staging	NOUN
dpc-539	126	15	and	and	CCONJ
dpc-539	126	16	adjuvant	adjuvant	ADJ
dpc-539	126	17	therapy	therapy	NOUN
dpc-539	126	18	.	.	PUNCT
dpc-539	127	1	eur	eur	PROPN
dpc-539	127	2	j	j	PROPN
dpc-539	127	3	cancer	cancer	NOUN
dpc-539	127	4	.	.	PUNCT
dpc-539	128	1	2014;50(15):2668	2014;50(15):2668	X
dpc-539	128	2	-	-	SYM
dpc-539	128	3	2676	2676	NUM
dpc-539	128	4	.	.	PUNCT
dpc-539	129	1	9	9	NUM
dpc-539	129	2	.	.	X
dpc-539	129	3	flaherty	flaherty	PROPN
dpc-539	129	4	kt	kt	PROPN
dpc-539	129	5	,	,	PUNCT
dpc-539	129	6	puzanov	puzanov	PROPN
dpc-539	129	7	i	i	PROPN
dpc-539	129	8	,	,	PUNCT
dpc-539	129	9	kim	kim	PROPN
dpc-539	129	10	kb	kb	PROPN
dpc-539	129	11	,	,	PUNCT
dpc-539	129	12	et	et	PROPN
dpc-539	129	13	 	 	SPACE
dpc-539	129	14	al	al	PROPN
dpc-539	129	15	.	.	PROPN
dpc-539	129	16	inhibition	inhibition	NOUN
dpc-539	129	17	of	of	ADP
dpc-539	129	18	mutated	mutate	VERB
dpc-539	129	19	,	,	PUNCT
dpc-539	129	20	activated	activate	VERB
dpc-539	129	21	braf	braf	NOUN
dpc-539	129	22	in	in	ADP
dpc-539	129	23	metastatic	metastatic	ADJ
dpc-539	129	24	melanoma	melanoma	NOUN
dpc-539	129	25	.	.	PUNCT
dpc-539	130	1	n	n	PRON
dpc-539	130	2	engl	engl	PROPN
dpc-539	130	3	j	j	PROPN
dpc-539	130	4	med	med	PROPN
dpc-539	130	5	.	.	PUNCT
dpc-539	131	1	2010;363(9):809–819	2010;363(9):809–819	NUM
dpc-539	131	2	.	.	NOUN
dpc-539	132	1	10	10	NUM
dpc-539	132	2	.	.	PUNCT
dpc-539	133	1	balch	balch	PROPN
dpc-539	133	2	cm	cm	PROPN
dpc-539	133	3	,	,	PUNCT
dpc-539	133	4	soong	soong	PROPN
dpc-539	133	5	s	s	PROPN
dpc-539	133	6	-	-	PUNCT
dpc-539	133	7	j	j	PROPN
dpc-539	133	8	,	,	PUNCT
dpc-539	133	9	gershenwald	gershenwald	PROPN
dpc-539	133	10	je	je	PROPN
dpc-539	133	11	,	,	PUNCT
dpc-539	133	12	et	et	PROPN
dpc-539	133	13	 	 	SPACE
dpc-539	133	14	al	al	PROPN
dpc-539	133	15	.	.	PROPN
dpc-539	134	1	prognostic	prognostic	ADJ
dpc-539	134	2	factors	factor	VERB
dpc-539	134	3	analysis	analysis	NOUN
dpc-539	134	4	of	of	ADP
dpc-539	134	5	17,600	17,600	NUM
dpc-539	134	6	melanoma	melanoma	NOUN
dpc-539	134	7	patients	patient	NOUN
dpc-539	134	8	:	:	PUNCT
dpc-539	134	9	validation	validation	NOUN
dpc-539	134	10	of	of	ADP
dpc-539	134	11	the	the	DET
dpc-539	134	12	american	american	PROPN
dpc-539	134	13	joint	joint	PROPN
dpc-539	134	14	committee	committee	PROPN
dpc-539	134	15	on	on	ADP
dpc-539	134	16	cancer	cancer	NOUN
dpc-539	134	17	melanoma	melanoma	NOUN
dpc-539	134	18	staging	staging	NOUN
dpc-539	134	19	system	system	NOUN
dpc-539	134	20	.	.	PUNCT
dpc-539	135	1	j	j	PROPN
dpc-539	135	2	clin	clin	PROPN
dpc-539	135	3	oncol	oncol	PROPN
dpc-539	135	4	.	.	PUNCT
dpc-539	136	1	2001;19(16):3622	2001;19(16):3622	NUM
dpc-539	136	2	-	-	SYM
dpc-539	136	3	3634	3634	NUM
dpc-539	136	4	.	.	PUNCT
dpc-539	137	1	11	11	NUM
dpc-539	137	2	.	.	PUNCT
dpc-539	138	1	spathis	spathis	PROPN
dpc-539	138	2	a	a	DET
dpc-539	138	3	,	,	PUNCT
dpc-539	138	4	georgoulakis	georgoulakis	PROPN
dpc-539	138	5	j	j	PROPN
dpc-539	138	6	,	,	PUNCT
dpc-539	138	7	foukas	foukas	NOUN
dpc-539	138	8	p	p	X
dpc-539	138	9	,	,	PUNCT
dpc-539	138	10	et	et	PROPN
dpc-539	138	11	 	 	SPACE
dpc-539	138	12	al	al	PROPN
dpc-539	138	13	.	.	PROPN
dpc-539	138	14	kras	kras	PROPN
dpc-539	138	15	and	and	CCONJ
dpc-539	138	16	braf	braf	NOUN
dpc-539	138	17	mutation	mutation	NOUN
dpc-539	138	18	analysis	analysis	NOUN
dpc-539	138	19	from	from	ADP
dpc-539	138	20	liquid	liquid	NOUN
dpc-539	138	21	-	-	PUNCT
dpc-539	138	22	based	base	VERB
dpc-539	138	23	cytology	cytology	NOUN
dpc-539	138	24	brushings	brushing	NOUN
dpc-539	138	25	of	of	ADP
dpc-539	138	26	colorectal	colorectal	ADJ
dpc-539	138	27	carcinoma	carcinoma	NOUN
dpc-539	138	28	in	in	ADP
dpc-539	138	29	comparison	comparison	NOUN
dpc-539	138	30	with	with	ADP
dpc-539	138	31	formalin	formalin	NOUN
dpc-539	138	32	-	-	PUNCT
dpc-539	138	33	fixed	fix	VERB
dpc-539	138	34	,	,	PUNCT
dpc-539	138	35	paraffin	paraffin	NOUN
dpc-539	138	36	-	-	PUNCT
dpc-539	138	37	embedded	embed	VERB
dpc-539	138	38	tissue	tissue	NOUN
dpc-539	138	39	.	.	PUNCT
dpc-539	139	1	anticancer	anticancer	NOUN
dpc-539	139	2	res	re	NOUN
dpc-539	139	3	.	.	PUNCT
dpc-539	140	1	2010;30(6):1969	2010;30(6):1969	NUM
dpc-539	140	2	-	-	SYM
dpc-539	140	3	1975	1975	NUM
dpc-539	140	4	.	.	PUNCT
dpc-539	141	1	12	12	NUM
dpc-539	141	2	.	.	PUNCT
dpc-539	142	1	ellerhorst	ellerhorst	PROPN
dpc-539	142	2	ja	ja	PROPN
dpc-539	142	3	,	,	PUNCT
dpc-539	142	4	greene	greene	PROPN
dpc-539	142	5	vr	vr	PROPN
dpc-539	142	6	,	,	PUNCT
dpc-539	142	7	ekmekcioglu	ekmekcioglu	PROPN
dpc-539	142	8	s	s	PROPN
dpc-539	142	9	,	,	PUNCT
dpc-539	142	10	et	et	PROPN
dpc-539	142	11	 	 	SPACE
dpc-539	142	12	al	al	PROPN
dpc-539	142	13	.	.	PROPN
dpc-539	143	1	clinical	clinical	PROPN
dpc-539	143	2	correlates	correlate	NOUN
dpc-539	143	3	of	of	ADP
dpc-539	143	4	nras	nras	PROPN
dpc-539	143	5	and	and	CCONJ
dpc-539	143	6	braf	braf	NOUN
dpc-539	143	7	mutations	mutation	NOUN
dpc-539	143	8	in	in	ADP
dpc-539	143	9	primary	primary	ADJ
dpc-539	143	10	human	human	ADJ
dpc-539	143	11	melanoma	melanoma	NOUN
dpc-539	143	12	.	.	PUNCT
dpc-539	144	1	clin	clin	PROPN
dpc-539	144	2	cancer	cancer	NOUN
dpc-539	144	3	res	re	NOUN
dpc-539	144	4	.	.	PUNCT
dpc-539	145	1	2011;17(2):229–235	2011;17(2):229–235	NUM
dpc-539	145	2	.	.	NOUN
dpc-539	145	3	13	13	NUM
dpc-539	145	4	.	.	PUNCT
dpc-539	146	1	jakob	jakob	PROPN
dpc-539	146	2	ja	ja	PROPN
dpc-539	146	3	,	,	PUNCT
dpc-539	146	4	bassett	bassett	PROPN
dpc-539	146	5	rl	rl	PROPN
dpc-539	146	6	jr	jr	PROPN
dpc-539	146	7	,	,	PUNCT
dpc-539	146	8	ng	ng	PROPN
dpc-539	146	9	cs	cs	PROPN
dpc-539	146	10	,	,	PUNCT
dpc-539	146	11	et	et	PROPN
dpc-539	146	12	 	 	SPACE
dpc-539	146	13	al	al	PROPN
dpc-539	146	14	.	.	PROPN
dpc-539	146	15	,	,	PUNCT
dpc-539	146	16	nras	nras	PROPN
dpc-539	146	17	mutation	mutation	NOUN
dpc-539	146	18	status	status	NOUN
dpc-539	146	19	is	be	AUX
dpc-539	146	20	an	an	DET
dpc-539	146	21	independent	independent	ADJ
dpc-539	146	22	prognostic	prognostic	ADJ
dpc-539	146	23	factor	factor	NOUN
dpc-539	146	24	in	in	ADP
dpc-539	146	25	metastatic	metastatic	ADJ
dpc-539	146	26	melanoma	melanoma	NOUN
dpc-539	146	27	.	.	PUNCT
dpc-539	147	1	cancer	cancer	NOUN
dpc-539	147	2	.	.	PUNCT
dpc-539	148	1	2012;118(16):4014	2012;118(16):4014	NUM
dpc-539	148	2	-	-	SYM
dpc-539	148	3	4023	4023	NUM
dpc-539	148	4	.	.	PUNCT
dpc-539	149	1	14	14	NUM
dpc-539	149	2	.	.	PUNCT
dpc-539	150	1	colombino	colombino	PROPN
dpc-539	150	2	m	m	PROPN
dpc-539	150	3	,	,	PUNCT
dpc-539	150	4	capone	capone	PROPN
dpc-539	150	5	m	m	PROPN
dpc-539	150	6	,	,	PUNCT
dpc-539	150	7	lissia	lissia	PROPN
dpc-539	150	8	a	a	NOUN
dpc-539	150	9	,	,	PUNCT
dpc-539	150	10	et	et	PROPN
dpc-539	150	11	 	 	SPACE
dpc-539	150	12	al	al	PROPN
dpc-539	150	13	.	.	PROPN
dpc-539	150	14	braf	braf	PROPN
dpc-539	150	15	/	/	SYM
dpc-539	150	16	nras	nras	PROPN
dpc-539	150	17	mutation	mutation	NOUN
dpc-539	150	18	frequencies	frequency	NOUN
dpc-539	150	19	among	among	ADP
dpc-539	150	20	primary	primary	ADJ
dpc-539	150	21	tumors	tumor	NOUN
dpc-539	150	22	and	and	CCONJ
dpc-539	150	23	metastases	metastasis	NOUN
dpc-539	150	24	in	in	ADP
dpc-539	150	25	patients	patient	NOUN
dpc-539	150	26	with	with	ADP
dpc-539	150	27	melanoma	melanoma	NOUN
dpc-539	150	28	.	.	PUNCT
dpc-539	151	1	j	j	PROPN
dpc-539	151	2	clin	clin	PROPN
dpc-539	151	3	oncol	oncol	PROPN
dpc-539	151	4	.	.	PUNCT
dpc-539	152	1	2012;30(20):2522	2012;30(20):2522	NUM
dpc-539	152	2	-	-	PUNCT
dpc-539	152	3	2529	2529	NUM
dpc-539	152	4	.	.	PUNCT
dpc-539	153	1	15	15	NUM
dpc-539	153	2	.	.	PUNCT
dpc-539	153	3	lee	lee	PROPN
dpc-539	153	4	jh	jh	PROPN
dpc-539	153	5	,	,	PUNCT
dpc-539	153	6	choi	choi	PROPN
dpc-539	153	7	jw	jw	PROPN
dpc-539	153	8	,	,	PUNCT
dpc-539	153	9	kim	kim	PROPN
dpc-539	153	10	ys	ys	PROPN
dpc-539	153	11	.	.	PUNCT
dpc-539	154	1	frequencies	frequency	NOUN
dpc-539	154	2	of	of	ADP
dpc-539	154	3	braf	braf	NOUN
dpc-539	154	4	and	and	CCONJ
dpc-539	154	5	nras	nras	PROPN
dpc-539	154	6	mutations	mutation	NOUN
dpc-539	154	7	are	be	AUX
dpc-539	154	8	different	different	ADJ
dpc-539	154	9	in	in	ADP
dpc-539	154	10	histological	histological	ADJ
dpc-539	154	11	types	type	NOUN
dpc-539	154	12	and	and	CCONJ
dpc-539	154	13	sites	site	NOUN
dpc-539	154	14	of	of	ADP
dpc-539	154	15	origin	origin	NOUN
dpc-539	154	16	of	of	ADP
dpc-539	154	17	cutaneous	cutaneous	ADJ
dpc-539	154	18	melanoma	melanoma	NOUN
dpc-539	154	19	:	:	PUNCT
dpc-539	154	20	a	a	DET
dpc-539	154	21	meta	meta	ADJ
dpc-539	154	22	-	-	PUNCT
dpc-539	154	23	analysis	analysis	NOUN
dpc-539	154	24	.	.	PUNCT
dpc-539	155	1	br	br	PROPN
dpc-539	155	2	j	j	PROPN
dpc-539	155	3	dermatol	dermatol	NOUN
dpc-539	155	4	.	.	PUNCT
dpc-539	156	1	2011;164(4):776	2011;164(4):776	NUM
dpc-539	156	2	-	-	PUNCT
dpc-539	156	3	784	784	NUM
dpc-539	156	4	.	.	PUNCT
dpc-539	157	1	16	16	NUM
dpc-539	157	2	.	.	PUNCT
dpc-539	158	1	kim	kim	PROPN
dpc-539	158	2	sy	sy	PROPN
dpc-539	158	3	,	,	PUNCT
dpc-539	158	4	kim	kim	PROPN
dpc-539	158	5	sn	sn	PROPN
dpc-539	158	6	,	,	PUNCT
dpc-539	158	7	hahn	hahn	PROPN
dpc-539	158	8	hj	hj	PROPN
dpc-539	158	9	,	,	PUNCT
dpc-539	158	10	lee	lee	PROPN
dpc-539	158	11	yw	yw	PROPN
dpc-539	158	12	,	,	PUNCT
dpc-539	158	13	choe	choe	PROPN
dpc-539	158	14	yb	yb	PROPN
dpc-539	158	15	,	,	PUNCT
dpc-539	158	16	ahn	ahn	PROPN
dpc-539	158	17	kj	kj	PROPN
dpc-539	158	18	.	.	PUNCT
dpc-539	158	19	metaanalysis	metaanalysis	NOUN
dpc-539	158	20	of	of	ADP
dpc-539	158	21	braf	braf	NOUN
dpc-539	158	22	mutations	mutation	NOUN
dpc-539	158	23	and	and	CCONJ
dpc-539	158	24	clinicopathologic	clinicopathologic	ADJ
dpc-539	158	25	characteristics	characteristic	NOUN
dpc-539	158	26	in	in	ADP
dpc-539	158	27	primary	primary	ADJ
dpc-539	158	28	melanoma	melanoma	NOUN
dpc-539	158	29	.	.	PUNCT
dpc-539	159	1	j	j	PROPN
dpc-539	159	2	am	be	AUX
dpc-539	159	3	acad	acad	ADJ
dpc-539	159	4	dermatol	dermatol	NOUN
dpc-539	159	5	.	.	PUNCT
dpc-539	160	1	2015;72(6):10361046.e2	2015;72(6):10361046.e2	NUM
dpc-539	160	2	.	.	PUNCT
dpc-539	161	1	17	17	NUM
dpc-539	161	2	.	.	PUNCT
dpc-539	162	1	yamazaki	yamazaki	PROPN
dpc-539	162	2	n	n	PROPN
dpc-539	162	3	,	,	PUNCT
dpc-539	162	4	tanaka	tanaka	PROPN
dpc-539	162	5	r	r	PROPN
dpc-539	162	6	,	,	PUNCT
dpc-539	162	7	tsutsumida	tsutsumida	PROPN
dpc-539	162	8	a	a	PRON
dpc-539	162	9	,	,	PUNCT
dpc-539	162	10	et	et	PROPN
dpc-539	162	11	 	 	SPACE
dpc-539	162	12	al	al	PROPN
dpc-539	162	13	.	.	PROPN
dpc-539	162	14	braf	braf	NOUN
dpc-539	162	15	v600	v600	PROPN
dpc-539	162	16	mutations	mutation	NOUN
dpc-539	162	17	and	and	CCONJ
dpc-539	162	18	pathological	pathological	ADJ
dpc-539	162	19	features	feature	NOUN
dpc-539	162	20	in	in	ADP
dpc-539	162	21	japanese	japanese	ADJ
dpc-539	162	22	melanoma	melanoma	NOUN
dpc-539	162	23	patients	patient	NOUN
dpc-539	162	24	.	.	PUNCT
dpc-539	163	1	melanoma	melanoma	NOUN
dpc-539	163	2	res	re	NOUN
dpc-539	163	3	.	.	PUNCT
dpc-539	164	1	2015;25(1):9	2015;25(1):9	NUM
dpc-539	164	2	-	-	SYM
dpc-539	164	3	14	14	NUM
dpc-539	164	4	.	.	PUNCT
dpc-539	165	1	18	18	NUM
dpc-539	165	2	.	.	PUNCT
dpc-539	166	1	mooi	mooi	PROPN
dpc-539	166	2	wj	wj	PROPN
dpc-539	166	3	,	,	PUNCT
dpc-539	166	4	krausz	krausz	ADJ
dpc-539	166	5	t.	t.	ADJ
dpc-539	166	6	melanoma	melanoma	NOUN
dpc-539	166	7	:	:	PUNCT
dpc-539	166	8	subtypes	subtype	NOUN
dpc-539	166	9	and	and	CCONJ
dpc-539	166	10	variants	variant	NOUN
dpc-539	166	11	.	.	PUNCT
dpc-539	167	1	in	in	ADP
dpc-539	167	2	:	:	PUNCT
dpc-539	167	3	hodder	hodder	PROPN
dpc-539	167	4	a	a	PRON
dpc-539	167	5	,	,	PUNCT
dpc-539	167	6	ed	ed	NOUN
dpc-539	167	7	.	.	PUNCT
dpc-539	167	8	pathology	pathology	NOUN
dpc-539	167	9	of	of	ADP
dpc-539	167	10	melanocytic	melanocytic	ADJ
dpc-539	167	11	disorders	disorder	NOUN
dpc-539	167	12	.	.	PUNCT
dpc-539	168	1	london	london	PROPN
dpc-539	168	2	:	:	PUNCT
dpc-539	168	3	taylor	taylor	PROPN
dpc-539	168	4	&	&	CCONJ
dpc-539	168	5	francis	francis	PROPN
dpc-539	168	6	ltd	ltd	PROPN
dpc-539	168	7	.	.	PROPN
dpc-539	168	8	2007:285	2007:285	PROPN
dpc-539	168	9	-	-	PUNCT
dpc-539	168	10	342	342	NUM
dpc-539	168	11	.	.	PUNCT
dpc-539	169	1	19	19	NUM
dpc-539	169	2	.	.	X
dpc-539	169	3	safaee	safaee	PROPN
dpc-539	169	4	ardekani	ardekani	VERB
dpc-539	169	5	g	g	PROPN
dpc-539	169	6	,	,	PUNCT
dpc-539	169	7	jafarnejad	jafarnejad	PROPN
dpc-539	169	8	sm	sm	PROPN
dpc-539	169	9	,	,	PUNCT
dpc-539	169	10	khosravi	khosravi	VERB
dpc-539	169	11	s	s	PROPN
dpc-539	169	12	,	,	PUNCT
dpc-539	169	13	martinka	martinka	PROPN
dpc-539	169	14	m	m	PROPN
dpc-539	169	15	,	,	PUNCT
dpc-539	169	16	ho	ho	PROPN
dpc-539	169	17	v	v	PROPN
dpc-539	169	18	,	,	PUNCT
dpc-539	169	19	li	li	PROPN
dpc-539	169	20	g.	g.	PROPN
dpc-539	169	21	disease	disease	PROPN
dpc-539	169	22	progression	progression	NOUN
dpc-539	169	23	and	and	CCONJ
dpc-539	169	24	patient	patient	ADJ
dpc-539	169	25	survival	survival	NOUN
dpc-539	169	26	are	be	AUX
dpc-539	169	27	significantly	significantly	ADV
dpc-539	169	28	influenced	influence	VERB
dpc-539	169	29	by	by	ADP
dpc-539	169	30	braf	braf	NOUN
dpc-539	169	31	protein	protein	NOUN
dpc-539	169	32	expression	expression	NOUN
dpc-539	169	33	in	in	ADP
dpc-539	169	34	primary	primary	ADJ
dpc-539	169	35	melanoma	melanoma	NOUN
dpc-539	169	36	.	.	PUNCT
dpc-539	170	1	br	br	PROPN
dpc-539	170	2	j	j	PROPN
dpc-539	170	3	dermatol	dermatol	NOUN
dpc-539	170	4	.	.	PUNCT
dpc-539	171	1	2013;169(2):320	2013;169(2):320	NUM
dpc-539	171	2	-	-	SYM
dpc-539	171	3	328	328	NUM
dpc-539	171	4	.	.	PUNCT
dpc-539	172	1	20	20	NUM
dpc-539	172	2	.	.	PUNCT
dpc-539	173	1	akslen	akslen	PROPN
dpc-539	173	2	la	la	PROPN
dpc-539	173	3	,	,	PUNCT
dpc-539	173	4	angelini	angelini	PROPN
dpc-539	173	5	s	s	PROPN
dpc-539	173	6	,	,	PUNCT
dpc-539	173	7	straume	straume	PROPN
dpc-539	173	8	o	o	PROPN
dpc-539	173	9	,	,	PUNCT
dpc-539	173	10	et	et	PROPN
dpc-539	173	11	 	 	SPACE
dpc-539	173	12	al	al	PROPN
dpc-539	173	13	.	.	PROPN
dpc-539	173	14	braf	braf	PROPN
dpc-539	173	15	and	and	CCONJ
dpc-539	173	16	nras	nras	PROPN
dpc-539	173	17	mutations	mutation	NOUN
dpc-539	173	18	are	be	AUX
dpc-539	173	19	frequent	frequent	ADJ
dpc-539	173	20	in	in	ADP
dpc-539	173	21	nodular	nodular	ADJ
dpc-539	173	22	melanoma	melanoma	NOUN
dpc-539	173	23	but	but	CCONJ
dpc-539	173	24	are	be	AUX
dpc-539	173	25	not	not	PART
dpc-539	173	26	associated	associate	VERB
dpc-539	173	27	with	with	ADP
dpc-539	173	28	tumor	tumor	NOUN
dpc-539	173	29	cell	cell	NOUN
dpc-539	173	30	proliferation	proliferation	NOUN
dpc-539	173	31	or	or	CCONJ
dpc-539	173	32	patient	patient	ADJ
dpc-539	173	33	survival	survival	NOUN
dpc-539	173	34	.	.	PUNCT
dpc-539	174	1	j	j	PROPN
dpc-539	174	2	invest	invest	VERB
dpc-539	174	3	dermatol	dermatol	NOUN
dpc-539	174	4	.	.	PUNCT
dpc-539	175	1	2005;125(2):312	2005;125(2):312	PROPN
dpc-539	175	2	-	-	SYM
dpc-539	175	3	317	317	NUM
dpc-539	175	4	.	.	PUNCT
dpc-539	176	1	21	21	NUM
dpc-539	176	2	.	.	PUNCT
dpc-539	177	1	hugdahl	hugdahl	PROPN
dpc-539	177	2	e	e	X
dpc-539	177	3	,	,	PUNCT
dpc-539	177	4	kalvenes	kalvenes	PROPN
dpc-539	177	5	mb	mb	PROPN
dpc-539	177	6	,	,	PUNCT
dpc-539	177	7	puntervoll	puntervoll	VERB
dpc-539	177	8	he	he	PRON
dpc-539	177	9	,	,	PUNCT
dpc-539	177	10	ladstein	ladstein	VERB
dpc-539	177	11	rg	rg	PROPN
dpc-539	177	12	,	,	PUNCT
dpc-539	177	13	akslen	akslen	VERB
dpc-539	177	14	la	la	PROPN
dpc-539	177	15	.	.	PUNCT
dpc-539	177	16	braf	braf	NOUN
dpc-539	177	17	-	-	PUNCT
dpc-539	177	18	v600e	v600e	NOUN
dpc-539	177	19	expression	expression	NOUN
dpc-539	177	20	in	in	ADP
dpc-539	177	21	primary	primary	ADJ
dpc-539	177	22	nodular	nodular	ADJ
dpc-539	177	23	melanoma	melanoma	NOUN
dpc-539	177	24	is	be	AUX
dpc-539	177	25	associated	associate	VERB
dpc-539	177	26	with	with	ADP
dpc-539	177	27	aggressive	aggressive	ADJ
dpc-539	177	28	tumour	tumour	NOUN
dpc-539	177	29	features	feature	NOUN
dpc-539	177	30	and	and	CCONJ
dpc-539	177	31	reduced	reduced	ADJ
dpc-539	177	32	survival	survival	NOUN
dpc-539	177	33	.	.	PUNCT
dpc-539	178	1	br	br	PROPN
dpc-539	178	2	j	j	PROPN
dpc-539	178	3	cancer	cancer	NOUN
dpc-539	178	4	.	.	PUNCT
dpc-539	179	1	2016;114(7):801	2016;114(7):801	NUM
dpc-539	179	2	-	-	SYM
dpc-539	179	3	808	808	NUM
dpc-539	179	4	.	.	NOUN
dpc-539	179	5	22	22	NUM
dpc-539	179	6	.	.	PUNCT
dpc-539	180	1	shen	shen	PROPN
dpc-539	180	2	s	s	PROPN
dpc-539	180	3	,	,	PUNCT
dpc-539	180	4	wolfe	wolfe	PROPN
dpc-539	180	5	r	r	PROPN
dpc-539	180	6	,	,	PUNCT
dpc-539	180	7	mclean	mclean	PROPN
dpc-539	180	8	ca	ca	PROPN
dpc-539	180	9	,	,	PUNCT
dpc-539	180	10	haskett	haskett	PROPN
dpc-539	180	11	m	m	PROPN
dpc-539	180	12	,	,	PUNCT
dpc-539	180	13	kelly	kelly	PROPN
dpc-539	180	14	jw	jw	PROPN
dpc-539	180	15	.	.	PROPN
dpc-539	180	16	characteristics	characteristic	NOUN
dpc-539	180	17	and	and	CCONJ
dpc-539	180	18	associations	association	NOUN
dpc-539	180	19	of	of	ADP
dpc-539	180	20	high	high	ADJ
dpc-539	180	21	-	-	PUNCT
dpc-539	180	22	mitotic	mitotic	ADJ
dpc-539	180	23	-	-	PUNCT
dpc-539	180	24	rate	rate	NOUN
dpc-539	180	25	melanoma	melanoma	NOUN
dpc-539	180	26	.	.	PUNCT
dpc-539	181	1	jama	jama	PROPN
dpc-539	181	2	dermatol	dermatol	NOUN
dpc-539	181	3	.	.	PUNCT
dpc-539	182	1	2014;150(10):1048	2014;150(10):1048	NUM
dpc-539	182	2	-	-	SYM
dpc-539	182	3	1055	1055	NUM
dpc-539	182	4	.	.	PUNCT
dpc-539	183	1	23	23	NUM
dpc-539	183	2	.	.	PUNCT
dpc-539	184	1	greene	greene	PROPN
dpc-539	184	2	vr	vr	PROPN
dpc-539	184	3	,	,	PUNCT
dpc-539	184	4	johnson	johnson	PROPN
dpc-539	184	5	mm	mm	PROPN
dpc-539	184	6	,	,	PUNCT
dpc-539	184	7	grimm	grimm	PROPN
dpc-539	184	8	ea	ea	PROPN
dpc-539	184	9	,	,	PUNCT
dpc-539	184	10	ellerhorst	ellerhorst	PROPN
dpc-539	184	11	ja	ja	PROPN
dpc-539	184	12	.	.	PUNCT
dpc-539	184	13	frequencies	frequency	NOUN
dpc-539	184	14	of	of	ADP
dpc-539	184	15	nras	nras	PROPN
dpc-539	184	16	and	and	CCONJ
dpc-539	184	17	braf	braf	NOUN
dpc-539	184	18	mutations	mutation	NOUN
dpc-539	184	19	increase	increase	VERB
dpc-539	184	20	from	from	ADP
dpc-539	184	21	the	the	DET
dpc-539	184	22	radial	radial	NOUN
dpc-539	184	23	to	to	ADP
dpc-539	184	24	the	the	DET
dpc-539	184	25	vertical	vertical	ADJ
dpc-539	184	26	growth	growth	NOUN
dpc-539	184	27	phase	phase	NOUN
dpc-539	184	28	in	in	ADP
dpc-539	184	29	cutaneous	cutaneous	ADJ
dpc-539	184	30	melanoma	melanoma	NOUN
dpc-539	184	31	.	.	PUNCT
dpc-539	185	1	j	j	PROPN
dpc-539	185	2	invest	invest	VERB
dpc-539	185	3	dermatol	dermatol	NOUN
dpc-539	185	4	.	.	PUNCT
dpc-539	186	1	2009;129(6):1483–1488	2009;129(6):1483–1488	NUM
dpc-539	186	2	.	.	PROPN
dpc-539	186	3	24	24	NUM
dpc-539	186	4	.	.	PUNCT
dpc-539	187	1	mar	mar	PROPN
dpc-539	187	2	vj	vj	PROPN
dpc-539	187	3	,	,	PUNCT
dpc-539	187	4	liu	liu	PROPN
dpc-539	187	5	w	w	PROPN
dpc-539	187	6	,	,	PUNCT
dpc-539	187	7	devitt	devitt	PROPN
dpc-539	187	8	b	b	PROPN
dpc-539	187	9	,	,	PUNCT
dpc-539	187	10	et	et	PROPN
dpc-539	187	11	 	 	SPACE
dpc-539	187	12	al	al	PROPN
dpc-539	187	13	.	.	PUNCT
dpc-539	188	1	the	the	DET
dpc-539	188	2	role	role	NOUN
dpc-539	188	3	of	of	ADP
dpc-539	188	4	braf	braf	NOUN
dpc-539	188	5	mutations	mutation	NOUN
dpc-539	188	6	in	in	ADP
dpc-539	188	7	primary	primary	ADJ
dpc-539	188	8	melanoma	melanoma	NOUN
dpc-539	188	9	growth	growth	NOUN
dpc-539	188	10	rate	rate	NOUN
dpc-539	188	11	and	and	CCONJ
dpc-539	188	12	survival	survival	NOUN
dpc-539	188	13	.	.	PUNCT
dpc-539	189	1	br	br	PROPN
dpc-539	189	2	j	j	PROPN
dpc-539	189	3	dermatol	dermatol	NOUN
dpc-539	189	4	.	.	PUNCT
dpc-539	190	1	2015;173(1):76	2015;173(1):76	NUM
dpc-539	190	2	-	-	SYM
dpc-539	190	3	82	82	NUM
dpc-539	190	4	.	.	PUNCT
dpc-539	191	1	25	25	NUM
dpc-539	191	2	.	.	PUNCT
dpc-539	192	1	akbani	akbani	PROPN
dpc-539	192	2	r	r	NOUN
dpc-539	192	3	,	,	PUNCT
dpc-539	192	4	akdemir	akdemir	PROPN
dpc-539	192	5	kc	kc	PROPN
dpc-539	192	6	,	,	PUNCT
dpc-539	192	7	aksoy	aksoy	PROPN
dpc-539	192	8	aa	aa	PROPN
dpc-539	192	9	,	,	PUNCT
dpc-539	192	10	et	et	PROPN
dpc-539	192	11	 	 	SPACE
dpc-539	192	12	al	al	PROPN
dpc-539	192	13	;	;	PUNCT
dpc-539	192	14	cancer	cancer	NOUN
dpc-539	192	15	genome	genome	NOUN
dpc-539	192	16	atlas	atlas	PROPN
dpc-539	192	17	network	network	PROPN
dpc-539	192	18	.	.	PUNCT
dpc-539	193	1	genomic	genomic	ADJ
dpc-539	193	2	classification	classification	NOUN
dpc-539	193	3	of	of	ADP
dpc-539	193	4	cutaneous	cutaneous	ADJ
dpc-539	193	5	melanoma	melanoma	NOUN
dpc-539	193	6	.	.	PUNCT
dpc-539	194	1	cell	cell	NOUN
dpc-539	194	2	.	.	PUNCT
dpc-539	195	1	2015;161(7):1681	2015;161(7):1681	NUM
dpc-539	195	2	-	-	SYM
dpc-539	195	3	1696	1696	NUM
dpc-539	195	4	.	.	PUNCT
dpc-539	196	1	braf	braf	NOUN
dpc-539	196	2	mutations	mutation	NOUN
dpc-539	196	3	have	have	AUX
dpc-539	196	4	been	be	AUX
dpc-539	196	5	previously	previously	ADV
dpc-539	196	6	linked	link	VERB
dpc-539	196	7	to	to	ADP
dpc-539	196	8	transition	transition	NOUN
dpc-539	196	9	from	from	ADP
dpc-539	196	10	radial	radial	NOUN
dpc-539	196	11	to	to	ADP
dpc-539	196	12	vertical	vertical	ADJ
dpc-539	196	13	growth	growth	NOUN
dpc-539	196	14	phase	phase	NOUN
dpc-539	196	15	[	[	X
dpc-539	196	16	6	6	NUM
dpc-539	196	17	,	,	PUNCT
dpc-539	196	18	23	23	NUM
dpc-539	196	19	]	]	PUNCT
dpc-539	196	20	;	;	PUNCT
dpc-539	196	21	to	to	ADP
dpc-539	196	22	shorter	short	ADJ
dpc-539	196	23	recurrence	recurrence	NOUN
dpc-539	196	24	-	-	PUNCT
dpc-539	196	25	free	free	ADJ
dpc-539	196	26	,	,	PUNCT
dpc-539	196	27	disease	disease	NOUN
dpc-539	196	28	-	-	PUNCT
dpc-539	196	29	specific	specific	ADJ
dpc-539	196	30	survival	survival	NOUN
dpc-539	196	31	[	[	X
dpc-539	196	32	8	8	NUM
dpc-539	196	33	]	]	PUNCT
dpc-539	196	34	;	;	PUNCT
dpc-539	196	35	and	and	CCONJ
dpc-539	196	36	to	to	ADP
dpc-539	196	37	overall	overall	ADJ
dpc-539	196	38	survival	survival	NOUN
dpc-539	196	39	with	with	ADP
dpc-539	196	40	a	a	DET
dpc-539	196	41	more	more	ADV
dpc-539	196	42	protracted	protracted	ADJ
dpc-539	196	43	growth	growth	NOUN
dpc-539	196	44	rate	rate	NOUN
dpc-539	196	45	[	[	X
dpc-539	196	46	24	24	NUM
dpc-539	196	47	]	]	PUNCT
dpc-539	196	48	.	.	PUNCT
dpc-539	197	1	however	however	ADV
dpc-539	197	2	,	,	PUNCT
dpc-539	197	3	the	the	DET
dpc-539	197	4	exact	exact	ADJ
dpc-539	197	5	role	role	NOUN
dpc-539	197	6	and	and	CCONJ
dpc-539	197	7	the	the	DET
dpc-539	197	8	pathways	pathway	NOUN
dpc-539	197	9	mirrored	mirror	VERB
dpc-539	197	10	in	in	ADP
dpc-539	197	11	specific	specific	ADJ
dpc-539	197	12	morphological	morphological	ADJ
dpc-539	197	13	features	feature	NOUN
dpc-539	197	14	such	such	ADJ
dpc-539	197	15	as	as	ADP
dpc-539	197	16	ulceration	ulceration	NOUN
dpc-539	197	17	and	and	CCONJ
dpc-539	197	18	pathology	pathology	NOUN
dpc-539	197	19	types	type	NOUN
dpc-539	197	20	is	be	AUX
dpc-539	197	21	elusive	elusive	ADJ
dpc-539	197	22	.	.	PUNCT
dpc-539	198	1	conclusions	conclusion	NOUN
dpc-539	198	2	our	our	PRON
dpc-539	198	3	results	result	NOUN
dpc-539	198	4	suggest	suggest	VERB
dpc-539	198	5	that	that	SCONJ
dpc-539	198	6	braf	braf	ADJ
dpc-539	198	7	mutations	mutation	NOUN
dpc-539	198	8	are	be	AUX
dpc-539	198	9	more	more	ADV
dpc-539	198	10	frequent	frequent	ADJ
dpc-539	198	11	in	in	ADP
dpc-539	198	12	ssm	ssm	PROPN
dpc-539	198	13	,	,	PUNCT
dpc-539	199	1	ulcerated	ulcerated	ADJ
dpc-539	199	2	mms	mms	NOUN
dpc-539	199	3	independent	independent	ADJ
dpc-539	199	4	of	of	ADP
dpc-539	199	5	histological	histological	ADJ
dpc-539	199	6	type	type	NOUN
dpc-539	199	7	,	,	PUNCT
dpc-539	199	8	and	and	CCONJ
dpc-539	199	9	mms	mms	NOUN
dpc-539	199	10	arising	arise	VERB
dpc-539	199	11	in	in	ADP
dpc-539	199	12	non	non	ADJ
dpc-539	199	13	–	–	PUNCT
dpc-539	199	14	chronically	chronically	ADV
dpc-539	199	15	sun	sun	NOUN
dpc-539	199	16	-	-	PUNCT
dpc-539	199	17	damaged	damage	VERB
dpc-539	199	18	skin	skin	NOUN
dpc-539	199	19	,	,	PUNCT
dpc-539	199	20	ie	ie	X
dpc-539	199	21	,	,	PUNCT
dpc-539	199	22	lacking	lack	VERB
dpc-539	199	23	solar	solar	ADJ
dpc-539	199	24	elastosis	elastosis	NOUN
dpc-539	199	25	.	.	PUNCT
dpc-539	200	1	a	a	DET
dpc-539	200	2	significantly	significantly	ADV
dpc-539	200	3	higher	high	ADJ
dpc-539	200	4	number	number	NOUN
dpc-539	200	5	of	of	ADP
dpc-539	200	6	cases	case	NOUN
dpc-539	200	7	is	be	AUX
dpc-539	200	8	required	require	VERB
dpc-539	200	9	to	to	PART
dpc-539	200	10	clarify	clarify	VERB
dpc-539	200	11	whether	whether	SCONJ
dpc-539	200	12	these	these	DET
dpc-539	200	13	correlations	correlation	NOUN
dpc-539	200	14	identified	identify	VERB
dpc-539	200	15	by	by	ADP
dpc-539	200	16	many	many	ADJ
dpc-539	200	17	studies	study	NOUN
dpc-539	200	18	,	,	PUNCT
dpc-539	200	19	as	as	ADV
dpc-539	200	20	well	well	ADV
dpc-539	200	21	as	as	ADP
dpc-539	200	22	ours	our	NOUN
dpc-539	200	23	,	,	PUNCT
dpc-539	200	24	are	be	AUX
dpc-539	200	25	influenced	influence	VERB
dpc-539	200	26	by	by	ADP
dpc-539	200	27	the	the	DET
dpc-539	200	28	variance	variance	NOUN
dpc-539	200	29	of	of	ADP
dpc-539	200	30	different	different	ADJ
dpc-539	200	31	populations	population	NOUN
dpc-539	200	32	,	,	PUNCT
dpc-539	200	33	ages	age	NOUN
dpc-539	200	34	,	,	PUNCT
dpc-539	200	35	and	and	CCONJ
dpc-539	200	36	melanoma	melanoma	NOUN
dpc-539	200	37	types	type	NOUN
dpc-539	200	38	included	include	VERB
dpc-539	200	39	in	in	ADP
dpc-539	200	40	each	each	DET
dpc-539	200	41	study	study	NOUN
dpc-539	200	42	.	.	PUNCT
dpc-539	201	1	braf	braf	NOUN
dpc-539	201	2	-	-	PUNCT
dpc-539	201	3	mutated	mutate	VERB
dpc-539	201	4	melanoma	melanoma	NOUN
dpc-539	201	5	patients	patient	NOUN
dpc-539	201	6	already	already	ADV
dpc-539	201	7	have	have	VERB
dpc-539	201	8	the	the	DET
dpc-539	201	9	advantage	advantage	NOUN
dpc-539	201	10	of	of	ADP
dpc-539	201	11	being	be	AUX
dpc-539	201	12	more	more	ADV
dpc-539	201	13	effectively	effectively	ADV
dpc-539	201	14	treated	treat	VERB
dpc-539	201	15	with	with	ADP
dpc-539	201	16	drugs	drug	NOUN
dpc-539	201	17	that	that	PRON
dpc-539	201	18	specifically	specifically	ADV
dpc-539	201	19	target	target	VERB
dpc-539	201	20	braf	braf	NOUN
dpc-539	201	21	-	-	PUNCT
dpc-539	201	22	mutated	mutate	VERB
dpc-539	201	23	cells	cell	NOUN
dpc-539	201	24	,	,	PUNCT
dpc-539	201	25	a	a	DET
dpc-539	201	26	fact	fact	NOUN
dpc-539	201	27	that	that	PRON
dpc-539	201	28	may	may	AUX
dpc-539	201	29	mask	mask	VERB
dpc-539	201	30	the	the	DET
dpc-539	201	31	potential	potential	ADJ
dpc-539	201	32	contribution	contribution	NOUN
dpc-539	201	33	of	of	ADP
dpc-539	201	34	mutation	mutation	NOUN
dpc-539	201	35	presence	presence	NOUN
dpc-539	201	36	to	to	PART
dpc-539	201	37	metastasis	metastasis	NOUN
dpc-539	201	38	development	development	NOUN
dpc-539	201	39	.	.	PUNCT
dpc-539	202	1	furthermore	furthermore	ADV
dpc-539	202	2	,	,	PUNCT
dpc-539	202	3	as	as	SCONJ
dpc-539	202	4	both	both	PRON
dpc-539	202	5	new	new	ADJ
dpc-539	202	6	immunerelated	immunerelated	ADJ
dpc-539	202	7	therapies	therapy	NOUN
dpc-539	202	8	and	and	CCONJ
dpc-539	202	9	driver	driver	NOUN
dpc-539	202	10	mutations	mutation	NOUN
dpc-539	202	11	for	for	ADP
dpc-539	202	12	development	development	NOUN
dpc-539	202	13	and	and	CCONJ
dpc-539	202	14	metastasis	metastasis	NOUN
dpc-539	202	15	of	of	ADP
dpc-539	202	16	mm	mm	PROPN
dpc-539	202	17	are	be	AUX
dpc-539	202	18	further	far	ADV
dpc-539	202	19	identified	identify	VERB
dpc-539	202	20	,	,	PUNCT
dpc-539	202	21	molecular	molecular	ADJ
dpc-539	202	22	profile	profile	NOUN
dpc-539	202	23	of	of	ADP
dpc-539	202	24	mms	mms	NOUN
dpc-539	202	25	may	may	AUX
dpc-539	202	26	contribute	contribute	VERB
dpc-539	202	27	to	to	ADP
dpc-539	202	28	distinguishing	distinguish	VERB
dpc-539	202	29	melanoma	melanoma	NOUN
dpc-539	202	30	types	type	NOUN
dpc-539	202	31	and	and	CCONJ
dpc-539	202	32	estimating	estimate	VERB
dpc-539	202	33	prognosis	prognosis	NOUN
dpc-539	202	34	more	more	ADV
dpc-539	202	35	accurately	accurately	ADV
dpc-539	202	36	[	[	X
dpc-539	202	37	25	25	NUM
dpc-539	202	38	]	]	PUNCT
dpc-539	202	39	.	.	PUNCT
dpc-539	203	1	acknowledgment	acknowledgment	NOUN
dpc-539	203	2	in	in	ADP
dpc-539	203	3	loving	love	VERB
dpc-539	203	4	memory	memory	NOUN
dpc-539	203	5	of	of	ADP
dpc-539	203	6	professor	professor	NOUN
dpc-539	203	7	petros	petros	PROPN
dpc-539	203	8	karakitsos	karakitsos	PROPN
dpc-539	203	9	,	,	PUNCT
dpc-539	203	10	a	a	DET
dpc-539	203	11	dedicated	dedicated	ADJ
dpc-539	203	12	doctor	doctor	NOUN
dpc-539	203	13	,	,	PUNCT
dpc-539	203	14	an	an	DET
dpc-539	203	15	outstanding	outstanding	ADJ
dpc-539	203	16	scientist	scientist	NOUN
dpc-539	203	17	and	and	CCONJ
dpc-539	203	18	a	a	DET
dpc-539	203	19	pythagorean	pythagorean	PROPN
dpc-539	203	20	teacher	teacher	NOUN
dpc-539	203	21	,	,	PUNCT
dpc-539	203	22	who	who	PRON
dpc-539	203	23	passed	pass	VERB
dpc-539	203	24	away	away	ADP
dpc-539	203	25	on	on	ADP
dpc-539	203	26	june	june	PROPN
dpc-539	203	27	26	26	NUM
dpc-539	203	28	,	,	PUNCT
dpc-539	203	29	2017	2017	NUM
dpc-539	203	30	.	.	PUNCT
dpc-539	204	1	references	reference	NOUN
dpc-539	204	2	1	1	NUM
dpc-539	204	3	.	.	PUNCT
dpc-539	204	4	siegel	siegel	PROPN
dpc-539	204	5	rl	rl	PROPN
dpc-539	204	6	,	,	PUNCT
dpc-539	204	7	miller	miller	PROPN
dpc-539	204	8	kd	kd	PROPN
dpc-539	204	9	,	,	PUNCT
dpc-539	204	10	jemal	jemal	ADJ
dpc-539	204	11	a.	a.	NOUN
dpc-539	204	12	cancer	cancer	PROPN
dpc-539	204	13	statistics	statistic	NOUN
dpc-539	204	14	,	,	PUNCT
dpc-539	204	15	2017	2017	NUM
dpc-539	204	16	.	.	PUNCT
dpc-539	205	1	ca	can	AUX
dpc-539	205	2	cancer	cancer	PROPN
dpc-539	205	3	j	j	PROPN
dpc-539	205	4	clin	clin	PROPN
dpc-539	205	5	.	.	PUNCT
dpc-539	206	1	2017;67(1):7	2017;67(1):7	NUM
dpc-539	206	2	-	-	PUNCT
dpc-539	206	3	30	30	NUM
dpc-539	206	4	.	.	PUNCT
dpc-539	207	1	2	2	X
dpc-539	207	2	.	.	X
dpc-539	207	3	davies	davies	PROPN
dpc-539	207	4	h	h	PROPN
dpc-539	207	5	,	,	PUNCT
dpc-539	207	6	bignell	bignell	VERB
dpc-539	207	7	gr	gr	PROPN
dpc-539	207	8	,	,	PUNCT
dpc-539	207	9	cox	cox	PROPN
dpc-539	207	10	c	c	X
dpc-539	207	11	,	,	PUNCT
dpc-539	207	12	et	et	PROPN
dpc-539	207	13	 	 	SPACE
dpc-539	207	14	al	al	PROPN
dpc-539	207	15	.	.	PUNCT
dpc-539	208	1	mutations	mutation	NOUN
dpc-539	208	2	of	of	ADP
dpc-539	208	3	the	the	DET
dpc-539	208	4	braf	braf	NOUN
dpc-539	208	5	gene	gene	NOUN
dpc-539	208	6	in	in	ADP
dpc-539	208	7	human	human	ADJ
dpc-539	208	8	cancer	cancer	NOUN
dpc-539	208	9	.	.	PUNCT
dpc-539	209	1	nature	nature	NOUN
dpc-539	209	2	.	.	PUNCT
dpc-539	210	1	2002;417(6892):949	2002;417(6892):949	NUM
dpc-539	210	2	-	-	SYM
dpc-539	210	3	954	954	NUM
dpc-539	210	4	.	.	NOUN
dpc-539	211	1	3	3	X
dpc-539	211	2	.	.	X
dpc-539	211	3	buscà	buscà	PROPN
dpc-539	211	4	r	r	NOUN
dpc-539	211	5	,	,	PUNCT
dpc-539	211	6	abbe	abbe	X
dpc-539	211	7	p	p	X
dpc-539	211	8	,	,	PUNCT
dpc-539	211	9	mantoux	mantoux	NOUN
dpc-539	211	10	f	f	PROPN
dpc-539	211	11	,	,	PUNCT
dpc-539	211	12	et	et	PROPN
dpc-539	211	13	 	 	SPACE
dpc-539	211	14	al	al	PROPN
dpc-539	211	15	.	.	PUNCT
dpc-539	212	1	ras	ras	PROPN
dpc-539	212	2	mediates	mediate	VERB
dpc-539	212	3	the	the	DET
dpc-539	212	4	campdependent	campdependent	ADJ
dpc-539	212	5	activation	activation	NOUN
dpc-539	212	6	of	of	ADP
dpc-539	212	7	extracellular	extracellular	ADJ
dpc-539	212	8	signal	signal	NOUN
dpc-539	212	9	-	-	PUNCT
dpc-539	212	10	regulated	regulate	VERB
dpc-539	212	11	kinases	kinase	NOUN
dpc-539	212	12	(	(	PUNCT
dpc-539	212	13	erks	erk	VERB
dpc-539	212	14	)	)	PUNCT
dpc-539	212	15	in	in	ADP
dpc-539	212	16	melanocytes	melanocyte	NOUN
dpc-539	212	17	.	.	PUNCT
dpc-539	213	1	embo	embo	PROPN
dpc-539	213	2	j.	j.	PROPN
dpc-539	213	3	2000;19(12):2900	2000;19(12):2900	NUM
dpc-539	213	4	-	-	NOUN
dpc-539	213	5	2910	2910	NUM
dpc-539	213	6	.	.	PUNCT
dpc-539	214	1	4	4	X
dpc-539	214	2	.	.	X
dpc-539	214	3	poynter	poynter	PROPN
dpc-539	214	4	jn	jn	PROPN
dpc-539	214	5	,	,	PUNCT
dpc-539	214	6	elder	elder	PROPN
dpc-539	214	7	jt	jt	PROPN
dpc-539	214	8	,	,	PUNCT
dpc-539	214	9	fullen	fullen	PROPN
dpc-539	214	10	dr	dr	PROPN
dpc-539	214	11	,	,	PUNCT
dpc-539	214	12	et	et	PROPN
dpc-539	214	13	 	 	SPACE
dpc-539	214	14	al	al	PROPN
dpc-539	214	15	.	.	PROPN
dpc-539	214	16	braf	braf	PROPN
dpc-539	214	17	and	and	CCONJ
dpc-539	214	18	nras	nras	PROPN
dpc-539	214	19	mutations	mutation	NOUN
dpc-539	214	20	in	in	ADP
dpc-539	214	21	melanoma	melanoma	NOUN
dpc-539	214	22	and	and	CCONJ
dpc-539	214	23	melanocytic	melanocytic	ADJ
dpc-539	214	24	nevi	nevi	NOUN
dpc-539	214	25	.	.	PUNCT
dpc-539	215	1	melanoma	melanoma	NOUN
dpc-539	215	2	res	re	NOUN
dpc-539	215	3	.	.	PUNCT
dpc-539	216	1	2006;16(4):267	2006;16(4):267	NUM
dpc-539	216	2	-	-	PUNCT
dpc-539	216	3	273	273	NUM
dpc-539	216	4	.	.	NOUN
dpc-539	216	5	5	5	NUM
dpc-539	216	6	.	.	X
dpc-539	216	7	arozarena	arozarena	PROPN
dpc-539	216	8	i	i	PRON
dpc-539	216	9	,	,	PUNCT
dpc-539	216	10	sanchez	sanchez	PROPN
dpc-539	216	11	-	-	PUNCT
dpc-539	216	12	laorden	laorden	PROPN
dpc-539	216	13	b	b	PROPN
dpc-539	216	14	,	,	PUNCT
dpc-539	216	15	packer	packer	PROPN
dpc-539	216	16	l	l	PROPN
dpc-539	216	17	,	,	PUNCT
dpc-539	216	18	et	et	PROPN
dpc-539	216	19	 	 	SPACE
dpc-539	217	1	al	al	PROPN
dpc-539	217	2	.	.	PUNCT
dpc-539	217	3	oncogenic	oncogenic	ADJ
dpc-539	217	4	braf	braf	NOUN
dpc-539	217	5	induces	induce	VERB
dpc-539	217	6	melanoma	melanoma	NOUN
dpc-539	217	7	cell	cell	NOUN
dpc-539	217	8	invasion	invasion	NOUN
dpc-539	217	9	by	by	ADP
dpc-539	217	10	downregulating	downregulate	VERB
dpc-539	217	11	the	the	DET
dpc-539	217	12	cgmpspecific	cgmpspecific	ADJ
dpc-539	217	13	phosphodiesterase	phosphodiesterase	NOUN
dpc-539	217	14	pde5a	pde5a	PROPN
dpc-539	217	15	.	.	PUNCT
dpc-539	218	1	cancer	cancer	NOUN
dpc-539	218	2	cell	cell	NOUN
dpc-539	218	3	.	.	PUNCT
dpc-539	219	1	2011;19(1):4557	2011;19(1):4557	NUM
dpc-539	219	2	.	.	PUNCT
dpc-539	220	1	6	6	NUM
dpc-539	220	2	.	.	X
dpc-539	220	3	dong	dong	PROPN
dpc-539	220	4	j	j	PROPN
dpc-539	220	5	,	,	PUNCT
dpc-539	220	6	phelps	phelps	PROPN
dpc-539	220	7	rg	rg	PROPN
dpc-539	220	8	,	,	PUNCT
dpc-539	220	9	qiao	qiao	PROPN
dpc-539	220	10	r	r	PROPN
dpc-539	220	11	,	,	PUNCT
dpc-539	220	12	et	et	PROPN
dpc-539	220	13	 	 	SPACE
dpc-539	220	14	al	al	PROPN
dpc-539	220	15	.	.	PUNCT
dpc-539	221	1	braf	braf	PROPN
dpc-539	221	2	oncogenic	oncogenic	ADJ
dpc-539	221	3	mutations	mutation	NOUN
dpc-539	221	4	correlate	correlate	VERB
dpc-539	221	5	with	with	ADP
dpc-539	221	6	progression	progression	NOUN
dpc-539	221	7	rather	rather	ADV
dpc-539	221	8	than	than	ADP
dpc-539	221	9	initiation	initiation	NOUN
dpc-539	221	10	of	of	ADP
dpc-539	221	11	human	human	ADJ
dpc-539	221	12	melanoma	melanoma	NOUN
dpc-539	221	13	.	.	PUNCT
dpc-539	222	1	cancer	cancer	NOUN
dpc-539	222	2	res	re	NOUN
dpc-539	222	3	.	.	PUNCT
dpc-539	223	1	2003;63(14	2003;63(14	NUM
dpc-539	223	2	):	):	PUNCT
dpc-539	223	3	3883	3883	NUM
dpc-539	223	4	-	-	SYM
dpc-539	223	5	3885	3885	NUM
dpc-539	223	6	.	.	PUNCT
dpc-539	224	1	7	7	X
dpc-539	224	2	.	.	X
dpc-539	224	3	shinozaki	shinozaki	PROPN
dpc-539	224	4	m	m	PROPN
dpc-539	224	5	,	,	PUNCT
dpc-539	224	6	fujimoto	fujimoto	PROPN
dpc-539	224	7	a	a	PROPN
dpc-539	224	8	,	,	PUNCT
dpc-539	224	9	morton	morton	PROPN
dpc-539	224	10	dl	dl	PROPN
dpc-539	224	11	,	,	PUNCT
dpc-539	224	12	hoon	hoon	PROPN
dpc-539	224	13	dsb	dsb	PROPN
dpc-539	224	14	.	.	PUNCT
dpc-539	225	1	incidence	incidence	NOUN
dpc-539	225	2	of	of	ADP
dpc-539	225	3	braf	braf	NOUN
dpc-539	225	4	oncogene	oncogene	NOUN
dpc-539	225	5	mutation	mutation	NOUN
dpc-539	225	6	and	and	CCONJ
dpc-539	225	7	clinical	clinical	ADJ
dpc-539	225	8	relevance	relevance	NOUN
dpc-539	225	9	for	for	ADP
dpc-539	225	10	primary	primary	ADJ
dpc-539	225	11	cutaneous	cutaneous	ADJ
dpc-539	225	12	melanomas	melanomas	NOUN
dpc-539	225	13	.	.	PUNCT
dpc-539	226	1	clin	clin	PROPN
dpc-539	226	2	cancer	cancer	NOUN
dpc-539	226	3	res	re	NOUN
dpc-539	226	4	.	.	PUNCT
dpc-539	227	1	2004;10(5):1753	2004;10(5):1753	NUM
dpc-539	227	2	-	-	SYM
dpc-539	227	3	1757	1757	NUM
dpc-539	227	4	.	.	PUNCT
dpc-539	228	1	8	8	X
dpc-539	228	2	.	.	X
dpc-539	228	3	barbour	barbour	PROPN
dpc-539	228	4	ap	ap	PROPN
dpc-539	228	5	,	,	PUNCT
dpc-539	228	6	tang	tang	PROPN
dpc-539	228	7	yh	yh	PROPN
dpc-539	228	8	,	,	PUNCT
dpc-539	228	9	armour	armour	NOUN
dpc-539	228	10	n	n	CCONJ
dpc-539	228	11	,	,	PUNCT
dpc-539	228	12	et	et	PROPN
dpc-539	228	13	 	 	SPACE
dpc-539	228	14	al	al	PROPN
dpc-539	228	15	.	.	PUNCT
dpc-539	229	1	braf	braf	PROPN
dpc-539	229	2	mutation	mutation	NOUN
dpc-539	229	3	status	status	NOUN
dpc-539	229	4	is	be	AUX
dpc-539	229	5	an	an	DET
dpc-539	229	6	independent	independent	ADJ
dpc-539	229	7	prognostic	prognostic	ADJ
dpc-539	229	8	factor	factor	NOUN
dpc-539	229	9	for	for	ADP
dpc-539	229	10	resected	resect	VERB
dpc-539	229	11	stage	stage	NOUN
dpc-539	229	12	iiib	iiib	NOUN
dpc-539	229	13	and	and	CCONJ