id	sid	tid	token	lemma	pos
dpc-5458	1	1	dermatology	dermatology	NOUN
dpc-5458	1	2	:	:	PUNCT
dpc-5458	1	3	practical	practical	ADJ
dpc-5458	1	4	and	and	CCONJ
dpc-5458	1	5	conceptual	conceptual	ADJ
dpc-5458	1	6	original	original	ADJ
dpc-5458	1	7	article	article	NOUN
dpc-5458	1	8	|	|	ADV
dpc-5458	1	9	dermatol	dermatol	ADJ
dpc-5458	1	10	pract	pract	NOUN
dpc-5458	1	11	concept	concept	NOUN
dpc-5458	1	12	.	.	PUNCT
dpc-5458	2	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	2	2	1	1	NUM
dpc-5458	2	3	elective	elective	ADJ
dpc-5458	2	4	first	first	ADJ
dpc-5458	2	5	-	-	PUNCT
dpc-5458	2	6	line	line	NOUN
dpc-5458	2	7	use	use	NOUN
dpc-5458	2	8	of	of	ADP
dpc-5458	2	9	dimethyl	dimethyl	NOUN
dpc-5458	2	10	fumarate	fumarate	NOUN
dpc-5458	2	11	in	in	ADP
dpc-5458	2	12	psoriasis	psoriasis	NOUN
dpc-5458	2	13	:	:	PUNCT
dpc-5458	2	14	insights	insight	NOUN
dpc-5458	2	15	from	from	ADP
dpc-5458	2	16	an	an	DET
dpc-5458	2	17	italian	italian	ADJ
dpc-5458	2	18	cohort	cohort	NOUN
dpc-5458	2	19	alessandro	alessandro	NOUN
dpc-5458	2	20	giunta1	giunta1	PROPN
dpc-5458	2	21	,	,	PUNCT
dpc-5458	2	22	*	*	PROPN
dpc-5458	2	23	,	,	PUNCT
dpc-5458	2	24	maria	maria	PROPN
dpc-5458	2	25	esposito2	esposito2	PROPN
dpc-5458	2	26	,	,	PUNCT
dpc-5458	2	27	*	*	PROPN
dpc-5458	2	28	,	,	PUNCT
dpc-5458	2	29	elena	elena	PROPN
dpc-5458	2	30	campione1	campione1	PROPN
dpc-5458	2	31	,	,	PUNCT
dpc-5458	2	32	martina	martina	PROPN
dpc-5458	2	33	burlando3,4	burlando3,4	PROPN
dpc-5458	2	34	,	,	PUNCT
dpc-5458	2	35	giacomo	giacomo	PROPN
dpc-5458	2	36	caldarola5,6	caldarola5,6	PROPN
dpc-5458	2	37	,	,	PUNCT
dpc-5458	2	38	viviana	viviana	PROPN
dpc-5458	2	39	lora7	lora7	PROPN
dpc-5458	2	40	,	,	PUNCT
dpc-5458	2	41	federico	federico	PROPN
dpc-5458	2	42	diotallevi8	diotallevi8	PROPN
dpc-5458	2	43	,	,	PUNCT
dpc-5458	2	44	ersilia	ersilia	PROPN
dpc-5458	2	45	tolino9	tolino9	PROPN
dpc-5458	2	46	,	,	PUNCT
dpc-5458	2	47	gianmarco	gianmarco	PROPN
dpc-5458	2	48	silvi10	silvi10	PROPN
dpc-5458	2	49	,	,	PUNCT
dpc-5458	2	50	emanuele	emanuele	PROPN
dpc-5458	2	51	cozzani3,4	cozzani3,4	PROPN
dpc-5458	2	52	,	,	PUNCT
dpc-5458	2	53	ruslana	ruslana	PROPN
dpc-5458	2	54	gaeta	gaeta	PROPN
dpc-5458	2	55	shumak1	shumak1	PROPN
dpc-5458	2	56	,	,	PUNCT
dpc-5458	2	57	rosaria	rosaria	PROPN
dpc-5458	2	58	fidanza11	fidanza11	NOUN
dpc-5458	2	59	,	,	PUNCT
dpc-5458	2	60	paolo	paolo	NOUN
dpc-5458	2	61	antonetti11	antonetti11	NOUN
dpc-5458	2	62	,	,	PUNCT
dpc-5458	2	63	lorenzo	lorenzo	PROPN
dpc-5458	2	64	maria	maria	PROPN
dpc-5458	2	65	pinto5,6	pinto5,6	PROPN
dpc-5458	2	66	,	,	PUNCT
dpc-5458	2	67	valentina	valentina	PROPN
dpc-5458	2	68	mirisola12	mirisola12	PROPN
dpc-5458	2	69	,	,	PUNCT
dpc-5458	2	70	maria	maria	PROPN
dpc-5458	2	71	concetta	concetta	PROPN
dpc-5458	2	72	fargnoli2	fargnoli2	PROPN
dpc-5458	2	73	,	,	PUNCT
dpc-5458	2	74	luca	luca	PROPN
dpc-5458	2	75	bianchi1	bianchi1	PROPN
dpc-5458	2	76	,	,	PUNCT
dpc-5458	2	77	francesca	francesca	PROPN
dpc-5458	2	78	prignano10	prignano10	NOUN
dpc-5458	2	79	1	1	NUM
dpc-5458	2	80	dermatologic	dermatologic	ADJ
dpc-5458	2	81	unit	unit	NOUN
dpc-5458	2	82	,	,	PUNCT
dpc-5458	2	83	department	department	NOUN
dpc-5458	2	84	of	of	ADP
dpc-5458	2	85	systems	system	NOUN
dpc-5458	2	86	medicine	medicine	NOUN
dpc-5458	2	87	,	,	PUNCT
dpc-5458	2	88	university	university	NOUN
dpc-5458	2	89	of	of	ADP
dpc-5458	2	90	rome	rome	PROPN
dpc-5458	2	91	tor	tor	PROPN
dpc-5458	2	92	vergata	vergata	PROPN
dpc-5458	2	93	,	,	PUNCT
dpc-5458	2	94	rome	rome	PROPN
dpc-5458	2	95	,	,	PUNCT
dpc-5458	2	96	italy	italy	PROPN
dpc-5458	2	97	2	2	NUM
dpc-5458	2	98	department	department	NOUN
dpc-5458	2	99	of	of	ADP
dpc-5458	2	100	biotechnological	biotechnological	ADJ
dpc-5458	2	101	and	and	CCONJ
dpc-5458	2	102	applied	apply	VERB
dpc-5458	2	103	clinical	clinical	ADJ
dpc-5458	2	104	sciences	science	NOUN
dpc-5458	2	105	,	,	PUNCT
dpc-5458	2	106	university	university	NOUN
dpc-5458	2	107	of	of	ADP
dpc-5458	2	108	l’aquila	l’aquila	PROPN
dpc-5458	2	109	,	,	PUNCT
dpc-5458	2	110	l’aquila	l’aquila	PROPN
dpc-5458	2	111	,	,	PUNCT
dpc-5458	2	112	italy	italy	PROPN
dpc-5458	2	113	3	3	NUM
dpc-5458	2	114	clinica	clinica	PROPN
dpc-5458	2	115	dermatologica	dermatologica	PROPN
dpc-5458	2	116	,	,	PUNCT
dpc-5458	2	117	dissal	dissal	NOUN
dpc-5458	2	118	,	,	PUNCT
dpc-5458	2	119	università	università	PROPN
dpc-5458	2	120	di	di	PROPN
dpc-5458	2	121	genova	genova	PROPN
dpc-5458	2	122	,	,	PUNCT
dpc-5458	2	123	genova	genova	PROPN
dpc-5458	2	124	,	,	PUNCT
dpc-5458	2	125	italy	italy	PROPN
dpc-5458	2	126	4	4	NUM
dpc-5458	2	127	ospedale	ospedale	PROPN
dpc-5458	2	128	policlinico	policlinico	PROPN
dpc-5458	2	129	san	san	PROPN
dpc-5458	2	130	martino	martino	PROPN
dpc-5458	2	131	-	-	PUNCT
dpc-5458	2	132	irccs	irccs	PROPN
dpc-5458	2	133	,	,	PUNCT
dpc-5458	2	134	genova	genova	PROPN
dpc-5458	2	135	,	,	PUNCT
dpc-5458	2	136	italy	italy	PROPN
dpc-5458	2	137	5	5	NUM
dpc-5458	2	138	uoc	uoc	PROPN
dpc-5458	2	139	di	di	NOUN
dpc-5458	2	140	dermatologia	dermatologia	PROPN
dpc-5458	2	141	,	,	PUNCT
dpc-5458	2	142	dipartimento	dipartimento	ADP
dpc-5458	2	143	di	di	PROPN
dpc-5458	2	144	scienze	scienze	PROPN
dpc-5458	2	145	mediche	mediche	PROPN
dpc-5458	2	146	e	e	PROPN
dpc-5458	2	147	chirurgiche	chirurgiche	PROPN
dpc-5458	2	148	,	,	PUNCT
dpc-5458	2	149	fondazione	fondazione	PROPN
dpc-5458	2	150	policlinico	policlinico	PROPN
dpc-5458	2	151	universitario	universitario	PROPN
dpc-5458	2	152	a.	a.	PROPN
dpc-5458	2	153	 	 	SPACE
dpc-5458	2	154	gemelli	gemelli	NOUN
dpc-5458	2	155	–	–	PUNCT
dpc-5458	2	156	irccs	irccs	NOUN
dpc-5458	2	157	,	,	PUNCT
dpc-5458	2	158	rome	rome	PROPN
dpc-5458	2	159	,	,	PUNCT
dpc-5458	2	160	italy	italy	PROPN
dpc-5458	2	161	6	6	NUM
dpc-5458	2	162	dermatologia	dermatologia	NOUN
dpc-5458	2	163	,	,	PUNCT
dpc-5458	2	164	dipartimento	dipartimento	ADP
dpc-5458	2	165	di	di	PROPN
dpc-5458	2	166	medicina	medicina	PROPN
dpc-5458	2	167	e	e	PROPN
dpc-5458	2	168	 	 	SPACE
dpc-5458	2	169	chirurgia	chirurgia	PROPN
dpc-5458	2	170	traslazionale	traslazionale	PROPN
dpc-5458	2	171	,	,	PUNCT
dpc-5458	2	172	università	università	PROPN
dpc-5458	2	173	cattolica	cattolica	PROPN
dpc-5458	2	174	del	del	PROPN
dpc-5458	2	175	sacro	sacro	PROPN
dpc-5458	2	176	cuore	cuore	PROPN
dpc-5458	2	177	,	,	PUNCT
dpc-5458	2	178	rome	rome	PROPN
dpc-5458	2	179	,	,	PUNCT
dpc-5458	2	180	italy	italy	PROPN
dpc-5458	2	181	7	7	NUM
dpc-5458	2	182	division	division	NOUN
dpc-5458	2	183	of	of	ADP
dpc-5458	2	184	dermatology	dermatology	NOUN
dpc-5458	2	185	,	,	PUNCT
dpc-5458	2	186	san	san	PROPN
dpc-5458	2	187	gallicano	gallicano	PROPN
dpc-5458	2	188	dermatological	dermatological	PROPN
dpc-5458	2	189	institute	institute	PROPN
dpc-5458	2	190	,	,	PUNCT
dpc-5458	2	191	rome	rome	PROPN
dpc-5458	2	192	,	,	PUNCT
dpc-5458	2	193	italy	italy	PROPN
dpc-5458	2	194	8	8	NUM
dpc-5458	2	195	dermatological	dermatological	ADJ
dpc-5458	2	196	clinic	clinic	NOUN
dpc-5458	2	197	,	,	PUNCT
dpc-5458	2	198	department	department	NOUN
dpc-5458	2	199	of	of	ADP
dpc-5458	2	200	clinical	clinical	ADJ
dpc-5458	2	201	and	and	CCONJ
dpc-5458	2	202	molecular	molecular	ADJ
dpc-5458	2	203	sciences	science	NOUN
dpc-5458	2	204	(	(	PUNCT
dpc-5458	2	205	disclimo	disclimo	PROPN
dpc-5458	2	206	)	)	PUNCT
dpc-5458	2	207	,	,	PUNCT
dpc-5458	2	208	università	università	PROPN
dpc-5458	2	209	politecnica	politecnica	PROPN
dpc-5458	2	210	delle	delle	PROPN
dpc-5458	2	211	marche	marche	PROPN
dpc-5458	2	212	,	,	PUNCT
dpc-5458	2	213	ancona	ancona	PROPN
dpc-5458	2	214	,	,	PUNCT
dpc-5458	2	215	italy	italy	PROPN
dpc-5458	2	216	9	9	NUM
dpc-5458	2	217	unit	unit	NOUN
dpc-5458	2	218	of	of	ADP
dpc-5458	2	219	dermatology	dermatology	NOUN
dpc-5458	2	220	,	,	PUNCT
dpc-5458	2	221	department	department	NOUN
dpc-5458	2	222	of	of	ADP
dpc-5458	2	223	medical	medical	ADJ
dpc-5458	2	224	-	-	PUNCT
dpc-5458	2	225	surgical	surgical	ADJ
dpc-5458	2	226	science	science	NOUN
dpc-5458	2	227	and	and	CCONJ
dpc-5458	2	228	biotechnologies	biotechnology	NOUN
dpc-5458	2	229	,	,	PUNCT
dpc-5458	2	230	sapienza	sapienza	PROPN
dpc-5458	2	231	university	university	PROPN
dpc-5458	2	232	of	of	ADP
dpc-5458	2	233	rome	rome	PROPN
dpc-5458	2	234	,	,	PUNCT
dpc-5458	2	235	a.	a.	PROPN
dpc-5458	2	236	fiorini	fiorini	PROPN
dpc-5458	2	237	hospital	hospital	PROPN
dpc-5458	2	238	,	,	PUNCT
dpc-5458	2	239	terracina	terracina	NOUN
dpc-5458	2	240	,	,	PUNCT
dpc-5458	2	241	latina	latina	PROPN
dpc-5458	2	242	,	,	PUNCT
dpc-5458	2	243	italy	italy	PROPN
dpc-5458	2	244	10	10	NUM
dpc-5458	2	245	section	section	NOUN
dpc-5458	2	246	of	of	ADP
dpc-5458	2	247	dermatology	dermatology	NOUN
dpc-5458	2	248	,	,	PUNCT
dpc-5458	2	249	department	department	NOUN
dpc-5458	2	250	of	of	ADP
dpc-5458	2	251	health	health	PROPN
dpc-5458	2	252	sciences	sciences	PROPN
dpc-5458	2	253	,	,	PUNCT
dpc-5458	2	254	university	university	NOUN
dpc-5458	2	255	of	of	ADP
dpc-5458	2	256	florence	florence	NOUN
dpc-5458	2	257	,	,	PUNCT
dpc-5458	2	258	florence	florence	NOUN
dpc-5458	2	259	,	,	PUNCT
dpc-5458	2	260	italy	italy	PROPN
dpc-5458	2	261	11	11	NUM
dpc-5458	2	262	uosd	uosd	PROPN
dpc-5458	2	263	dermatologia	dermatologia	PROPN
dpc-5458	2	264	generale	generale	PROPN
dpc-5458	2	265	ed	ed	PROPN
dpc-5458	2	266	oncologica	oncologica	PROPN
dpc-5458	2	267	ospedale	ospedale	PROPN
dpc-5458	2	268	san	san	PROPN
dpc-5458	2	269	salvatore	salvatore	PROPN
dpc-5458	2	270	l’aquila	l’aquila	PROPN
dpc-5458	3	1	asl1	asl1	PROPN
dpc-5458	3	2	abruzzo	abruzzo	PROPN
dpc-5458	3	3	,	,	PUNCT
dpc-5458	3	4	l’aquila	l’aquila	PROPN
dpc-5458	3	5	,	,	PUNCT
dpc-5458	3	6	italy	italy	PROPN
dpc-5458	3	7	12	12	NUM
dpc-5458	3	8	polistudium	polistudium	PROPN
dpc-5458	3	9	srl	srl	PROPN
dpc-5458	3	10	,	,	PUNCT
dpc-5458	3	11	milan	milan	PROPN
dpc-5458	3	12	,	,	PUNCT
dpc-5458	3	13	italy	italy	PROPN
dpc-5458	3	14	*	*	PUNCT
dpc-5458	3	15	equally	equally	ADV
dpc-5458	3	16	contributed	contribute	VERB
dpc-5458	3	17	key	key	ADJ
dpc-5458	3	18	words	word	NOUN
dpc-5458	3	19	:	:	PUNCT
dpc-5458	3	20	dimethyl	dimethyl	NOUN
dpc-5458	3	21	fumarate	fumarate	NOUN
dpc-5458	3	22	,	,	PUNCT
dpc-5458	3	23	psoriasis	psoriasis	NOUN
dpc-5458	3	24	,	,	PUNCT
dpc-5458	3	25	systemic	systemic	ADJ
dpc-5458	3	26	therapy	therapy	NOUN
dpc-5458	3	27	,	,	PUNCT
dpc-5458	3	28	first	first	ADJ
dpc-5458	3	29	-	-	PUNCT
dpc-5458	3	30	line	line	NOUN
dpc-5458	3	31	treatment	treatment	NOUN
dpc-5458	3	32	,	,	PUNCT
dpc-5458	3	33	long	long	ADJ
dpc-5458	3	34	-	-	PUNCT
dpc-5458	3	35	term	term	NOUN
dpc-5458	3	36	treatment	treatment	NOUN
dpc-5458	3	37	citation	citation	NOUN
dpc-5458	3	38	:	:	PUNCT
dpc-5458	3	39	giunta	giunta	PROPN
dpc-5458	3	40	a	a	PROPN
dpc-5458	3	41	,	,	PUNCT
dpc-5458	3	42	esposito	esposito	PROPN
dpc-5458	3	43	m	m	PROPN
dpc-5458	3	44	,	,	PUNCT
dpc-5458	3	45	campione	campione	PROPN
dpc-5458	3	46	e	e	NOUN
dpc-5458	3	47	,	,	PUNCT
dpc-5458	3	48	et	et	PROPN
dpc-5458	3	49	al	al	PROPN
dpc-5458	3	50	.	.	PUNCT
dpc-5458	4	1	elective	elective	ADJ
dpc-5458	4	2	first	first	ADJ
dpc-5458	4	3	-	-	PUNCT
dpc-5458	4	4	line	line	NOUN
dpc-5458	4	5	use	use	NOUN
dpc-5458	4	6	of	of	ADP
dpc-5458	4	7	dimethyl	dimethyl	NOUN
dpc-5458	4	8	fumarate	fumarate	NOUN
dpc-5458	4	9	in	in	ADP
dpc-5458	4	10	psoriasis	psoriasis	NOUN
dpc-5458	4	11	:	:	PUNCT
dpc-5458	4	12	insights	insight	NOUN
dpc-5458	4	13	from	from	ADP
dpc-5458	4	14	an	an	DET
dpc-5458	4	15	italian	italian	ADJ
dpc-5458	4	16	cohort	cohort	NOUN
dpc-5458	4	17	.	.	PUNCT
dpc-5458	5	1	dermatol	dermatol	NOUN
dpc-5458	5	2	pract	pract	PROPN
dpc-5458	5	3	concept	concept	NOUN
dpc-5458	5	4	.	.	PUNCT
dpc-5458	6	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	6	2	.	.	PUNCT
dpc-5458	7	1	doi	doi	PROPN
dpc-5458	7	2	:	:	PUNCT
dpc-5458	7	3	https://doi.org/10.5826/dpc.1504a5458	https://doi.org/10.5826/dpc.1504a5458	PROPN
dpc-5458	7	4	accepted	accept	VERB
dpc-5458	7	5	:	:	PUNCT
dpc-5458	7	6	june	june	PROPN
dpc-5458	7	7	25	25	NUM
dpc-5458	7	8	,	,	PUNCT
dpc-5458	7	9	2025	2025	NUM
dpc-5458	7	10	;	;	PUNCT
dpc-5458	7	11	published	publish	VERB
dpc-5458	7	12	:	:	PUNCT
dpc-5458	8	1	october	october	PROPN
dpc-5458	8	2	2025	2025	NUM
dpc-5458	8	3	copyright	copyright	NOUN
dpc-5458	8	4	:	:	PUNCT
dpc-5458	8	5	©	©	PROPN
dpc-5458	8	6	2025	2025	NUM
dpc-5458	8	7	giunta	giunta	PROPN
dpc-5458	8	8	et	et	PROPN
dpc-5458	8	9	al	al	PROPN
dpc-5458	8	10	.	.	PUNCT
dpc-5458	9	1	this	this	PRON
dpc-5458	9	2	is	be	AUX
dpc-5458	9	3	an	an	DET
dpc-5458	9	4	open	open	ADJ
dpc-5458	9	5	-	-	PUNCT
dpc-5458	9	6	access	access	NOUN
dpc-5458	9	7	article	article	NOUN
dpc-5458	9	8	distributed	distribute	VERB
dpc-5458	9	9	under	under	ADP
dpc-5458	9	10	the	the	DET
dpc-5458	9	11	terms	term	NOUN
dpc-5458	9	12	of	of	ADP
dpc-5458	9	13	the	the	DET
dpc-5458	9	14	creative	creative	ADJ
dpc-5458	9	15	commons	common	NOUN
dpc-5458	9	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-5458	9	17	license	license	NOUN
dpc-5458	9	18	(	(	PUNCT
dpc-5458	9	19	by	by	ADP
dpc-5458	9	20	-	-	PUNCT
dpc-5458	9	21	nc-4.0	nc-4.0	NOUN
dpc-5458	9	22	)	)	PUNCT
dpc-5458	9	23	,	,	PUNCT
dpc-5458	9	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-5458	9	25	,	,	PUNCT
dpc-5458	9	26	which	which	PRON
dpc-5458	9	27	permits	permit	VERB
dpc-5458	9	28	unrestricted	unrestricted	ADJ
dpc-5458	9	29	noncommercial	noncommercial	ADJ
dpc-5458	9	30	use	use	NOUN
dpc-5458	9	31	,	,	PUNCT
dpc-5458	9	32	distribution	distribution	NOUN
dpc-5458	9	33	,	,	PUNCT
dpc-5458	9	34	and	and	CCONJ
dpc-5458	9	35	reproduction	reproduction	NOUN
dpc-5458	9	36	in	in	ADP
dpc-5458	9	37	any	any	DET
dpc-5458	9	38	medium	medium	NOUN
dpc-5458	9	39	,	,	PUNCT
dpc-5458	9	40	provided	provide	VERB
dpc-5458	9	41	the	the	DET
dpc-5458	9	42	original	original	ADJ
dpc-5458	9	43	authors	author	NOUN
dpc-5458	9	44	and	and	CCONJ
dpc-5458	9	45	source	source	NOUN
dpc-5458	9	46	are	be	AUX
dpc-5458	9	47	credited	credit	VERB
dpc-5458	9	48	.	.	PUNCT
dpc-5458	10	1	funding	funding	NOUN
dpc-5458	10	2	:	:	PUNCT
dpc-5458	10	3	the	the	DET
dpc-5458	10	4	work	work	NOUN
dpc-5458	10	5	was	be	AUX
dpc-5458	10	6	unconditionally	unconditionally	ADV
dpc-5458	10	7	funded	fund	VERB
dpc-5458	10	8	by	by	ADP
dpc-5458	10	9	almirall	almirall	PROPN
dpc-5458	10	10	s.a	s.a	PROPN
dpc-5458	10	11	.	.	PROPN
dpc-5458	10	12	competing	compete	VERB
dpc-5458	10	13	interests	interest	NOUN
dpc-5458	10	14	:	:	PUNCT
dpc-5458	10	15	m.	m.	PROPN
dpc-5458	10	16	esposito	esposito	PROPN
dpc-5458	10	17	has	have	AUX
dpc-5458	10	18	served	serve	VERB
dpc-5458	10	19	as	as	ADP
dpc-5458	10	20	a	a	DET
dpc-5458	10	21	speaker	speaker	NOUN
dpc-5458	10	22	/	/	SYM
dpc-5458	10	23	board	board	NOUN
dpc-5458	10	24	member	member	NOUN
dpc-5458	10	25	for	for	ADP
dpc-5458	10	26	abbvie	abbvie	PROPN
dpc-5458	10	27	,	,	PUNCT
dpc-5458	10	28	almirall	almirall	PROPN
dpc-5458	10	29	,	,	PUNCT
dpc-5458	10	30	eli	eli	PROPN
dpc-5458	10	31	lilly	lilly	PROPN
dpc-5458	10	32	,	,	PUNCT
dpc-5458	10	33	janssen	janssen	PROPN
dpc-5458	10	34	,	,	PUNCT
dpc-5458	10	35	leo	leo	PROPN
dpc-5458	10	36	pharma	pharma	PROPN
dpc-5458	10	37	,	,	PUNCT
dpc-5458	10	38	novartis	novartis	PROPN
dpc-5458	10	39	,	,	PUNCT
dpc-5458	10	40	sanofi	sanofi	PROPN
dpc-5458	10	41	,	,	PUNCT
dpc-5458	10	42	and	and	CCONJ
dpc-5458	10	43	ucb	ucb	PROPN
dpc-5458	10	44	.	.	PUNCT
dpc-5458	11	1	a.	a.	PROPN
dpc-5458	11	2	giunta	giunta	PROPN
dpc-5458	11	3	received	receive	VERB
dpc-5458	11	4	grants	grant	NOUN
dpc-5458	11	5	or	or	CCONJ
dpc-5458	11	6	is	be	AUX
dpc-5458	11	7	an	an	DET
dpc-5458	11	8	investigator	investigator	NOUN
dpc-5458	11	9	for	for	ADP
dpc-5458	11	10	biogen	biogen	PROPN
dpc-5458	11	11	and	and	CCONJ
dpc-5458	11	12	lilly	lilly	PROPN
dpc-5458	11	13	and	and	CCONJ
dpc-5458	11	14	is	be	AUX
dpc-5458	11	15	a	a	DET
dpc-5458	11	16	consultant	consultant	NOUN
dpc-5458	11	17	/	/	SYM
dpc-5458	11	18	advisory	advisory	ADJ
dpc-5458	11	19	board	board	NOUN
dpc-5458	11	20	/	/	SYM
dpc-5458	11	21	speaker	speaker	NOUN
dpc-5458	11	22	for	for	ADP
dpc-5458	11	23	abbvie	abbvie	PROPN
dpc-5458	11	24	,	,	PUNCT
dpc-5458	11	25	almirall	almirall	ADJ
dpc-5458	11	26	,	,	PUNCT
dpc-5458	11	27	celgene	celgene	NOUN
dpc-5458	11	28	,	,	PUNCT
dpc-5458	11	29	janssen	janssen	PROPN
dpc-5458	11	30	,	,	PUNCT
dpc-5458	11	31	leo	leo	PROPN
dpc-5458	11	32	pharma	pharma	PROPN
dpc-5458	11	33	,	,	PUNCT
dpc-5458	11	34	eli	eli	PROPN
dpc-5458	11	35	lilly	lilly	PROPN
dpc-5458	11	36	,	,	PUNCT
dpc-5458	11	37	merck	merck	PROPN
dpc-5458	11	38	sharpe	sharpe	PROPN
dpc-5458	11	39	dohme	dohme	PROPN
dpc-5458	11	40	,	,	PUNCT
dpc-5458	11	41	novartis	novartis	NOUN
dpc-5458	11	42	,	,	PUNCT
dpc-5458	11	43	pfizer	pfizer	NOUN
dpc-5458	11	44	,	,	PUNCT
dpc-5458	11	45	sandoz	sandoz	PROPN
dpc-5458	11	46	,	,	PUNCT
dpc-5458	11	47	and	and	CCONJ
dpc-5458	11	48	ucb	ucb	PROPN
dpc-5458	11	49	.	.	PROPN
dpc-5458	11	50	m.	m.	PROPN
dpc-5458	11	51	burlando	burlando	PROPN
dpc-5458	11	52	served	serve	VERB
dpc-5458	11	53	as	as	ADP
dpc-5458	11	54	a	a	DET
dpc-5458	11	55	speaker	speaker	NOUN
dpc-5458	11	56	or	or	CCONJ
dpc-5458	11	57	advisory	advisory	ADJ
dpc-5458	11	58	board	board	NOUN
dpc-5458	11	59	member	member	NOUN
dpc-5458	11	60	for	for	ADP
dpc-5458	11	61	almirall	almirall	NOUN
dpc-5458	11	62	,	,	PUNCT
dpc-5458	11	63	abbvie	abbvie	PROPN
dpc-5458	11	64	,	,	PUNCT
dpc-5458	11	65	amgen	amgen	PROPN
dpc-5458	11	66	,	,	PUNCT
dpc-5458	11	67	eli	eli	PROPN
dpc-5458	11	68	lilly	lilly	PROPN
dpc-5458	11	69	,	,	PUNCT
dpc-5458	11	70	janssen	janssen	PROPN
dpc-5458	11	71	,	,	PUNCT
dpc-5458	11	72	leopharma	leopharma	PROPN
dpc-5458	11	73	,	,	PUNCT
dpc-5458	11	74	novartis	novartis	PROPN
dpc-5458	11	75	,	,	PUNCT
dpc-5458	11	76	and	and	CCONJ
dpc-5458	11	77	ucb	ucb	PROPN
dpc-5458	11	78	pharma	pharma	PROPN
dpc-5458	11	79	.	.	PUNCT
dpc-5458	12	1	g.	g.	PROPN
dpc-5458	12	2	caldarola	caldarola	PROPN
dpc-5458	12	3	reports	report	VERB
dpc-5458	12	4	consulting	consult	VERB
dpc-5458	12	5	fees	fee	NOUN
dpc-5458	12	6	or	or	CCONJ
dpc-5458	12	7	honorariums	honorarium	NOUN
dpc-5458	12	8	and	and	CCONJ
dpc-5458	12	9	payment	payment	NOUN
dpc-5458	12	10	for	for	ADP
dpc-5458	12	11	lectures	lecture	NOUN
dpc-5458	12	12	from	from	ADP
dpc-5458	12	13	lilly	lilly	NOUN
dpc-5458	12	14	and	and	CCONJ
dpc-5458	12	15	novartis	novartis	PROPN
dpc-5458	12	16	.	.	PUNCT
dpc-5458	13	1	mc	mc	PROPN
dpc-5458	13	2	fargnoli	fargnoli	PROPN
dpc-5458	13	3	has	have	AUX
dpc-5458	13	4	served	serve	VERB
dpc-5458	13	5	on	on	ADP
dpc-5458	13	6	advisory	advisory	ADJ
dpc-5458	13	7	boards	board	NOUN
dpc-5458	13	8	and	and	CCONJ
dpc-5458	13	9	received	receive	VERB
dpc-5458	13	10	honoraria	honorarium	NOUN
dpc-5458	13	11	for	for	ADP
dpc-5458	13	12	lectures	lecture	NOUN
dpc-5458	13	13	and/or	and/or	CCONJ
dpc-5458	13	14	research	research	NOUN
dpc-5458	13	15	grants	grant	NOUN
dpc-5458	13	16	from	from	ADP
dpc-5458	13	17	amgen	amgen	PROPN
dpc-5458	13	18	,	,	PUNCT
dpc-5458	13	19	almirall	almirall	ADJ
dpc-5458	13	20	,	,	PUNCT
dpc-5458	13	21	abbvie	abbvie	PROPN
dpc-5458	13	22	,	,	PUNCT
dpc-5458	13	23	boehringer	boehringer	PROPN
dpc-5458	13	24	-	-	PUNCT
dpc-5458	13	25	ingelheim	ingelheim	PROPN
dpc-5458	13	26	,	,	PUNCT
dpc-5458	13	27	bms	bms	PROPN
dpc-5458	13	28	,	,	PUNCT
dpc-5458	13	29	galderma	galderma	NOUN
dpc-5458	13	30	,	,	PUNCT
dpc-5458	13	31	kyowa	kyowa	PROPN
dpc-5458	13	32	kyrin	kyrin	PROPN
dpc-5458	13	33	,	,	PUNCT
dpc-5458	13	34	leo	leo	PROPN
dpc-5458	13	35	pharma	pharma	PROPN
dpc-5458	13	36	,	,	PUNCT
dpc-5458	13	37	pierre	pierre	PROPN
dpc-5458	13	38	fabre	fabre	PROPN
dpc-5458	13	39	,	,	PUNCT
dpc-5458	13	40	ucb	ucb	PROPN
dpc-5458	13	41	,	,	PUNCT
dpc-5458	13	42	lilly	lilly	PROPN
dpc-5458	13	43	,	,	PUNCT
dpc-5458	13	44	pfizer	pfizer	PROPN
dpc-5458	13	45	,	,	PUNCT
dpc-5458	13	46	janssen	janssen	PROPN
dpc-5458	13	47	,	,	PUNCT
dpc-5458	13	48	msd	msd	PROPN
dpc-5458	13	49	,	,	PUNCT
dpc-5458	13	50	novartis	novartis	PROPN
dpc-5458	13	51	,	,	PUNCT
dpc-5458	13	52	sanofi	sanofi	NOUN
dpc-5458	13	53	-	-	PUNCT
dpc-5458	13	54	regeneron	regeneron	NOUN
dpc-5458	13	55	,	,	PUNCT
dpc-5458	13	56	and	and	CCONJ
dpc-5458	13	57	sunpharma	sunpharma	NOUN
dpc-5458	13	58	.	.	PUNCT
dpc-5458	14	1	authorship	authorship	NOUN
dpc-5458	14	2	:	:	PUNCT
dpc-5458	14	3	all	all	DET
dpc-5458	14	4	authors	author	NOUN
dpc-5458	14	5	have	have	AUX
dpc-5458	14	6	contributed	contribute	VERB
dpc-5458	14	7	significantly	significantly	ADV
dpc-5458	14	8	to	to	ADP
dpc-5458	14	9	this	this	DET
dpc-5458	14	10	publication	publication	NOUN
dpc-5458	14	11	.	.	PUNCT
dpc-5458	15	1	corresponding	correspond	VERB
dpc-5458	15	2	author	author	NOUN
dpc-5458	15	3	:	:	PUNCT
dpc-5458	15	4	maria	maria	PROPN
dpc-5458	15	5	esposito	esposito	PROPN
dpc-5458	15	6	,	,	PUNCT
dpc-5458	15	7	md	md	PROPN
dpc-5458	15	8	,	,	PUNCT
dpc-5458	15	9	dermatology	dermatology	NOUN
dpc-5458	15	10	,	,	PUNCT
dpc-5458	15	11	department	department	NOUN
dpc-5458	15	12	of	of	ADP
dpc-5458	15	13	biotechnological	biotechnological	ADJ
dpc-5458	15	14	ad	ad	NOUN
dpc-5458	15	15	applied	apply	VERB
dpc-5458	15	16	clinical	clinical	ADJ
dpc-5458	15	17	sciences	science	NOUN
dpc-5458	15	18	,	,	PUNCT
dpc-5458	15	19	university	university	NOUN
dpc-5458	15	20	of	of	ADP
dpc-5458	15	21	l’aquila	l’aquila	PROPN
dpc-5458	15	22	,	,	PUNCT
dpc-5458	15	23	via	via	ADP
dpc-5458	15	24	vetoio	vetoio	ADV
dpc-5458	15	25	-	-	PUNCT
dpc-5458	15	26	coppito	coppito	ADJ
dpc-5458	15	27	2	2	NUM
dpc-5458	15	28	,	,	PUNCT
dpc-5458	15	29	67100	67100	NUM
dpc-5458	15	30	l’aquila	l’aquila	PROPN
dpc-5458	15	31	,	,	PUNCT
dpc-5458	15	32	italy	italy	PROPN
dpc-5458	15	33	.	.	PUNCT
dpc-5458	16	1	orcid	orcid	PROPN
dpc-5458	16	2	:	:	PUNCT
dpc-5458	16	3	0000	0000	NUM
dpc-5458	16	4	-	-	PUNCT
dpc-5458	16	5	0002	0002	NUM
dpc-5458	16	6	-	-	PUNCT
dpc-5458	16	7	4773	4773	NUM
dpc-5458	16	8	-	-	PUNCT
dpc-5458	16	9	6993	6993	NUM
dpc-5458	16	10	;	;	PUNCT
dpc-5458	16	11	e	e	X
dpc-5458	16	12	-	-	NOUN
dpc-5458	16	13	mail	mail	NOUN
dpc-5458	16	14	:	:	PUNCT
dpc-5458	16	15	maria.esposito3@univaq.it	maria.esposito3@univaq.it	NOUN
dpc-5458	16	16	2	2	NUM
dpc-5458	16	17	original	original	ADJ
dpc-5458	16	18	article	article	NOUN
dpc-5458	16	19	|	|	ADV
dpc-5458	16	20	dermatol	dermatol	ADJ
dpc-5458	16	21	pract	pract	NOUN
dpc-5458	16	22	concept	concept	NOUN
dpc-5458	16	23	.	.	PUNCT
dpc-5458	17	1	2025;15(4):5458	2025;15(4):5458	ADJ
dpc-5458	17	2	introduction	introduction	NOUN
dpc-5458	17	3	psoriasis	psoriasis	NOUN
dpc-5458	17	4	is	be	AUX
dpc-5458	17	5	a	a	DET
dpc-5458	17	6	chronic	chronic	ADJ
dpc-5458	17	7	inflammatory	inflammatory	ADJ
dpc-5458	17	8	disease	disease	NOUN
dpc-5458	17	9	characterized	characterize	VERB
dpc-5458	17	10	by	by	ADP
dpc-5458	17	11	high	high	ADJ
dpc-5458	17	12	prevalence	prevalence	NOUN
dpc-5458	17	13	and	and	CCONJ
dpc-5458	17	14	a	a	DET
dpc-5458	17	15	relevant	relevant	ADJ
dpc-5458	17	16	physical	physical	ADJ
dpc-5458	17	17	and	and	CCONJ
dpc-5458	17	18	psychological	psychological	ADJ
dpc-5458	17	19	burden	burden	NOUN
dpc-5458	17	20	[	[	X
dpc-5458	17	21	1	1	X
dpc-5458	17	22	]	]	PUNCT
dpc-5458	17	23	often	often	ADV
dpc-5458	17	24	requiring	require	VERB
dpc-5458	17	25	systemic	systemic	ADJ
dpc-5458	17	26	treatments	treatment	NOUN
dpc-5458	17	27	,	,	PUNCT
dpc-5458	17	28	either	either	CCONJ
dpc-5458	17	29	with	with	ADP
dpc-5458	17	30	conventional	conventional	ADJ
dpc-5458	17	31	or	or	CCONJ
dpc-5458	17	32	biological	biological	ADJ
dpc-5458	17	33	agents	agent	NOUN
dpc-5458	17	34	[	[	X
dpc-5458	17	35	2	2	NUM
dpc-5458	17	36	]	]	PUNCT
dpc-5458	17	37	.	.	PUNCT
dpc-5458	18	1	the	the	DET
dpc-5458	18	2	introduction	introduction	NOUN
dpc-5458	18	3	of	of	ADP
dpc-5458	18	4	biologicals	biological	NOUN
dpc-5458	18	5	targeting	target	VERB
dpc-5458	18	6	tumor	tumor	NOUN
dpc-5458	18	7	necrosis	necrosis	NOUN
dpc-5458	18	8	factor	factor	NOUN
dpc-5458	18	9	-	-	PUNCT
dpc-5458	18	10	α	α	X
dpc-5458	18	11	(	(	PUNCT
dpc-5458	18	12	tnf	tnf	PROPN
dpc-5458	18	13	-	-	PUNCT
dpc-5458	18	14	α	α	NOUN
dpc-5458	18	15	)	)	PUNCT
dpc-5458	18	16	,	,	PUNCT
dpc-5458	18	17	interleukin(il)-12/23	interleukin(il)-12/23	PROPN
dpc-5458	18	18	,	,	PUNCT
dpc-5458	18	19	il-17a	il-17a	PROPN
dpc-5458	18	20	,	,	PUNCT
dpc-5458	18	21	il-17ra	il-17ra	PROPN
dpc-5458	18	22	,	,	PUNCT
dpc-5458	18	23	and	and	CCONJ
dpc-5458	18	24	il-23	il-23	NOUN
dpc-5458	18	25	as	as	ADV
dpc-5458	18	26	well	well	ADV
dpc-5458	18	27	as	as	ADP
dpc-5458	18	28	the	the	DET
dpc-5458	18	29	small	small	ADJ
dpc-5458	18	30	-	-	PUNCT
dpc-5458	18	31	molecule	molecule	NOUN
dpc-5458	18	32	apremilast	apremilast	NOUN
dpc-5458	18	33	has	have	AUX
dpc-5458	18	34	provided	provide	VERB
dpc-5458	18	35	new	new	ADJ
dpc-5458	18	36	and	and	CCONJ
dpc-5458	18	37	effective	effective	ADJ
dpc-5458	18	38	treatment	treatment	NOUN
dpc-5458	18	39	options	option	NOUN
dpc-5458	18	40	,	,	PUNCT
dpc-5458	18	41	partially	partially	ADV
dpc-5458	18	42	reducing	reduce	VERB
dpc-5458	18	43	the	the	DET
dpc-5458	18	44	use	use	NOUN
dpc-5458	18	45	of	of	ADP
dpc-5458	18	46	conventional	conventional	ADJ
dpc-5458	18	47	therapies	therapy	NOUN
dpc-5458	18	48	[	[	X
dpc-5458	18	49	3	3	NUM
dpc-5458	18	50	]	]	PUNCT
dpc-5458	18	51	.	.	PUNCT
dpc-5458	19	1	however	however	ADV
dpc-5458	19	2	,	,	PUNCT
dpc-5458	19	3	in	in	ADP
dpc-5458	19	4	many	many	ADJ
dpc-5458	19	5	countries	country	NOUN
dpc-5458	19	6	,	,	PUNCT
dpc-5458	19	7	local	local	ADJ
dpc-5458	19	8	guidelines	guideline	NOUN
dpc-5458	19	9	recommend	recommend	VERB
dpc-5458	19	10	a	a	DET
dpc-5458	19	11	stepwise	stepwise	ADJ
dpc-5458	19	12	approach	approach	NOUN
dpc-5458	19	13	,	,	PUNCT
dpc-5458	19	14	starting	start	VERB
dpc-5458	19	15	with	with	ADP
dpc-5458	19	16	traditional	traditional	ADJ
dpc-5458	19	17	systemic	systemic	ADJ
dpc-5458	19	18	therapies	therapy	NOUN
dpc-5458	19	19	before	before	ADP
dpc-5458	19	20	initiating	initiate	VERB
dpc-5458	19	21	biological	biological	ADJ
dpc-5458	19	22	treatments	treatment	NOUN
dpc-5458	19	23	[	[	X
dpc-5458	19	24	4	4	NUM
dpc-5458	19	25	]	]	PUNCT
dpc-5458	19	26	.	.	PUNCT
dpc-5458	20	1	the	the	DET
dpc-5458	20	2	italian	italian	ADJ
dpc-5458	20	3	sidemast	sidemast	NOUN
dpc-5458	20	4	(	(	PUNCT
dpc-5458	20	5	società	società	PROPN
dpc-5458	20	6	italiana	italiana	PROPN
dpc-5458	20	7	di	di	PROPN
dpc-5458	20	8	dermatologia	dermatologia	PROPN
dpc-5458	20	9	medica	medica	PROPN
dpc-5458	20	10	,	,	PUNCT
dpc-5458	20	11	chirurgica	chirurgica	PROPN
dpc-5458	20	12	,	,	PUNCT
dpc-5458	20	13	estetica	estetica	PROPN
dpc-5458	20	14	e	e	PROPN
dpc-5458	20	15	delle	delle	PROPN
dpc-5458	20	16	malattie	malattie	PROPN
dpc-5458	20	17	sessualmente	sessualmente	PROPN
dpc-5458	20	18	trasmesse	trasmesse	PROPN
dpc-5458	20	19	)	)	PUNCT
dpc-5458	20	20	guidelines	guideline	NOUN
dpc-5458	20	21	recommend	recommend	VERB
dpc-5458	20	22	the	the	DET
dpc-5458	20	23	use	use	NOUN
dpc-5458	20	24	of	of	ADP
dpc-5458	20	25	biological	biological	ADJ
dpc-5458	20	26	therapies	therapy	NOUN
dpc-5458	20	27	for	for	ADP
dpc-5458	20	28	patients	patient	NOUN
dpc-5458	20	29	with	with	ADP
dpc-5458	20	30	moderate	moderate	ADJ
dpc-5458	20	31	-	-	PUNCT
dpc-5458	20	32	to	to	ADP
dpc-5458	20	33	-	-	PUNCT
dpc-5458	20	34	severe	severe	ADJ
dpc-5458	20	35	plaque	plaque	NOUN
dpc-5458	20	36	psoriasis	psoriasis	NOUN
dpc-5458	20	37	,	,	PUNCT
dpc-5458	20	38	defined	define	VERB
dpc-5458	20	39	as	as	ADP
dpc-5458	20	40	psoriasis	psoriasis	NOUN
dpc-5458	20	41	area	area	NOUN
dpc-5458	20	42	severity	severity	NOUN
dpc-5458	20	43	index	index	NOUN
dpc-5458	20	44	(	(	PUNCT
dpc-5458	20	45	pasi	pasi	NOUN
dpc-5458	20	46	)	)	PUNCT
dpc-5458	20	47	>	>	SYM
dpc-5458	20	48	10	10	NUM
dpc-5458	20	49	or	or	CCONJ
dpc-5458	20	50	body	body	NOUN
dpc-5458	20	51	surface	surface	NOUN
dpc-5458	20	52	area	area	NOUN
dpc-5458	20	53	(	(	PUNCT
dpc-5458	20	54	bsa	bsa	PROPN
dpc-5458	20	55	)	)	PUNCT
dpc-5458	20	56	>	>	PUNCT
dpc-5458	20	57	10	10	NUM
dpc-5458	20	58	,	,	PUNCT
dpc-5458	20	59	or	or	CCONJ
dpc-5458	20	60	pasi	pasi	NOUN
dpc-5458	20	61	<	<	X
dpc-5458	20	62	10	10	NUM
dpc-5458	20	63	and	and	CCONJ
dpc-5458	20	64	bsa	bsa	NOUN
dpc-5458	20	65	<	<	X
dpc-5458	20	66	10	10	NUM
dpc-5458	20	67	with	with	ADP
dpc-5458	20	68	involvement	involvement	NOUN
dpc-5458	20	69	of	of	ADP
dpc-5458	20	70	sensitive	sensitive	ADJ
dpc-5458	20	71	areas	area	NOUN
dpc-5458	20	72	such	such	ADJ
dpc-5458	20	73	as	as	ADP
dpc-5458	20	74	the	the	DET
dpc-5458	20	75	face	face	NOUN
dpc-5458	20	76	,	,	PUNCT
dpc-5458	20	77	palms	palm	NOUN
dpc-5458	20	78	,	,	PUNCT
dpc-5458	20	79	soles	sol	NOUN
dpc-5458	20	80	,	,	PUNCT
dpc-5458	20	81	nails	nail	NOUN
dpc-5458	20	82	,	,	PUNCT
dpc-5458	20	83	or	or	CCONJ
dpc-5458	20	84	genital	genital	ADJ
dpc-5458	20	85	region	region	NOUN
dpc-5458	20	86	or	or	CCONJ
dpc-5458	20	87	in	in	ADP
dpc-5458	20	88	those	those	PRON
dpc-5458	20	89	who	who	PRON
dpc-5458	20	90	have	have	AUX
dpc-5458	20	91	shown	show	VERB
dpc-5458	20	92	inadequate	inadequate	ADJ
dpc-5458	20	93	response	response	NOUN
dpc-5458	20	94	or	or	CCONJ
dpc-5458	20	95	intolerance	intolerance	NOUN
dpc-5458	20	96	to	to	ADP
dpc-5458	20	97	conventional	conventional	ADJ
dpc-5458	20	98	treatments	treatment	NOUN
dpc-5458	20	99	[	[	X
dpc-5458	20	100	2,5	2,5	NUM
dpc-5458	20	101	]	]	PUNCT
dpc-5458	20	102	.	.	PUNCT
dpc-5458	21	1	although	although	SCONJ
dpc-5458	21	2	the	the	DET
dpc-5458	21	3	therapeutic	therapeutic	ADJ
dpc-5458	21	4	target	target	NOUN
dpc-5458	21	5	of	of	ADP
dpc-5458	21	6	new	new	ADJ
dpc-5458	21	7	biological	biological	ADJ
dpc-5458	21	8	therapies	therapy	NOUN
dpc-5458	21	9	is	be	AUX
dpc-5458	21	10	pasi	pasi	NOUN
dpc-5458	21	11	90	90	NUM
dpc-5458	21	12	[	[	SYM
dpc-5458	21	13	6	6	NUM
dpc-5458	21	14	]	]	PUNCT
dpc-5458	21	15	,	,	PUNCT
dpc-5458	21	16	pasi	pasi	NOUN
dpc-5458	21	17	75	75	NUM
dpc-5458	21	18	remains	remain	VERB
dpc-5458	21	19	an	an	DET
dpc-5458	21	20	excellent	excellent	ADJ
dpc-5458	21	21	tool	tool	NOUN
dpc-5458	21	22	for	for	ADP
dpc-5458	21	23	evaluating	evaluate	VERB
dpc-5458	21	24	the	the	DET
dpc-5458	21	25	efficacy	efficacy	NOUN
dpc-5458	21	26	of	of	ADP
dpc-5458	21	27	traditional	traditional	ADJ
dpc-5458	21	28	therapies	therapy	NOUN
dpc-5458	21	29	for	for	ADP
dpc-5458	21	30	psoriasis	psoriasis	NOUN
dpc-5458	21	31	[	[	X
dpc-5458	21	32	7,8	7,8	NUM
dpc-5458	21	33	]	]	PUNCT
dpc-5458	21	34	.	.	PUNCT
dpc-5458	22	1	traditional	traditional	ADJ
dpc-5458	22	2	systemic	systemic	ADJ
dpc-5458	22	3	treatments	treatment	NOUN
dpc-5458	22	4	,	,	PUNCT
dpc-5458	22	5	including	include	VERB
dpc-5458	22	6	methotrexate	methotrexate	NOUN
dpc-5458	22	7	(	(	PUNCT
dpc-5458	22	8	mtx	mtx	NOUN
dpc-5458	22	9	)	)	PUNCT
dpc-5458	22	10	,	,	PUNCT
dpc-5458	22	11	cyclosporin	cyclosporin	NOUN
dpc-5458	22	12	,	,	PUNCT
dpc-5458	22	13	acitretin	acitretin	NOUN
dpc-5458	22	14	,	,	PUNCT
dpc-5458	22	15	and	and	CCONJ
dpc-5458	22	16	,	,	PUNCT
dpc-5458	22	17	in	in	ADP
dpc-5458	22	18	europe	europe	PROPN
dpc-5458	22	19	,	,	PUNCT
dpc-5458	22	20	fumaric	fumaric	ADJ
dpc-5458	22	21	acid	acid	NOUN
dpc-5458	22	22	esters	ester	NOUN
dpc-5458	22	23	(	(	PUNCT
dpc-5458	22	24	faes	faes	PROPN
dpc-5458	22	25	)	)	PUNCT
dpc-5458	22	26	,	,	PUNCT
dpc-5458	22	27	have	have	AUX
dpc-5458	22	28	demonstrated	demonstrate	VERB
dpc-5458	22	29	moderate	moderate	ADJ
dpc-5458	22	30	efficacy	efficacy	NOUN
dpc-5458	22	31	,	,	PUNCT
dpc-5458	22	32	with	with	ADP
dpc-5458	22	33	a	a	DET
dpc-5458	22	34	proportion	proportion	NOUN
dpc-5458	22	35	of	of	ADP
dpc-5458	22	36	patients	patient	NOUN
dpc-5458	22	37	achieving	achieve	VERB
dpc-5458	22	38	pasi	pasi	NOUN
dpc-5458	22	39	75	75	NUM
dpc-5458	22	40	ranging	range	VERB
dpc-5458	22	41	from	from	ADP
dpc-5458	22	42	15	15	NUM
dpc-5458	22	43	%	%	NOUN
dpc-5458	22	44	to	to	PART
dpc-5458	22	45	60	60	NUM
dpc-5458	22	46	%	%	NOUN
dpc-5458	22	47	[	[	X
dpc-5458	22	48	4	4	NUM
dpc-5458	22	49	]	]	PUNCT
dpc-5458	22	50	.	.	PUNCT
dpc-5458	23	1	remarkably	remarkably	ADV
dpc-5458	23	2	,	,	PUNCT
dpc-5458	23	3	except	except	SCONJ
dpc-5458	23	4	for	for	ADP
dpc-5458	23	5	faes	faes	PROPN
dpc-5458	23	6	,	,	PUNCT
dpc-5458	23	7	these	these	DET
dpc-5458	23	8	drugs	drug	NOUN
dpc-5458	23	9	exhibit	exhibit	VERB
dpc-5458	23	10	drug	drug	NOUN
dpc-5458	23	11	–	–	PUNCT
dpc-5458	23	12	drug	drug	NOUN
dpc-5458	23	13	interactions	interaction	NOUN
dpc-5458	23	14	and	and	CCONJ
dpc-5458	23	15	cumulative	cumulative	ADJ
dpc-5458	23	16	organ	organ	NOUN
dpc-5458	23	17	toxicities	toxicity	NOUN
dpc-5458	23	18	[	[	X
dpc-5458	23	19	9	9	NUM
dpc-5458	23	20	]	]	PUNCT
dpc-5458	23	21	.	.	PUNCT
dpc-5458	24	1	of	of	ADP
dpc-5458	24	2	note	note	NOUN
dpc-5458	24	3	,	,	PUNCT
dpc-5458	24	4	the	the	DET
dpc-5458	24	5	prescription	prescription	NOUN
dpc-5458	24	6	of	of	ADP
dpc-5458	24	7	systemic	systemic	ADJ
dpc-5458	24	8	drugs	drug	NOUN
dpc-5458	24	9	for	for	ADP
dpc-5458	24	10	psoriasis	psoriasis	NOUN
dpc-5458	24	11	in	in	ADP
dpc-5458	24	12	italy	italy	PROPN
dpc-5458	24	13	is	be	AUX
dpc-5458	24	14	regulated	regulate	VERB
dpc-5458	24	15	by	by	ADP
dpc-5458	24	16	the	the	DET
dpc-5458	24	17	agenzia	agenzia	PROPN
dpc-5458	24	18	italiana	italiana	PROPN
dpc-5458	24	19	del	del	PROPN
dpc-5458	24	20	farmaco	farmaco	PROPN
dpc-5458	24	21	(	(	PUNCT
dpc-5458	24	22	aifa	aifa	PROPN
dpc-5458	24	23	)	)	PUNCT
dpc-5458	24	24	and	and	CCONJ
dpc-5458	24	25	is	be	AUX
dpc-5458	24	26	influenced	influence	VERB
dpc-5458	24	27	not	not	PART
dpc-5458	24	28	only	only	ADV
dpc-5458	24	29	by	by	ADP
dpc-5458	24	30	the	the	DET
dpc-5458	24	31	safety	safety	NOUN
dpc-5458	24	32	profile	profile	NOUN
dpc-5458	24	33	but	but	CCONJ
dpc-5458	24	34	also	also	ADV
dpc-5458	24	35	by	by	ADP
dpc-5458	24	36	approved	approve	VERB
dpc-5458	24	37	indications	indication	NOUN
dpc-5458	24	38	and	and	CCONJ
dpc-5458	24	39	reimbursement	reimbursement	NOUN
dpc-5458	24	40	policies	policy	NOUN
dpc-5458	24	41	.	.	PUNCT
dpc-5458	25	1	mtx	mtx	NOUN
dpc-5458	25	2	is	be	AUX
dpc-5458	25	3	one	one	NUM
dpc-5458	25	4	of	of	ADP
dpc-5458	25	5	the	the	DET
dpc-5458	25	6	most	most	ADV
dpc-5458	25	7	widely	widely	ADV
dpc-5458	25	8	recommended	recommend	VERB
dpc-5458	25	9	first	first	ADJ
dpc-5458	25	10	-	-	PUNCT
dpc-5458	25	11	line	line	NOUN
dpc-5458	25	12	systemic	systemic	ADJ
dpc-5458	25	13	therapies	therapy	NOUN
dpc-5458	25	14	for	for	ADP
dpc-5458	25	15	moderate	moderate	ADJ
dpc-5458	25	16	-	-	PUNCT
dpc-5458	25	17	to	to	ADP
dpc-5458	25	18	-	-	PUNCT
dpc-5458	25	19	severe	severe	ADJ
dpc-5458	25	20	chronic	chronic	ADJ
dpc-5458	25	21	plaque	plaque	NOUN
dpc-5458	25	22	psoriasis	psoriasis	NOUN
dpc-5458	25	23	and	and	CCONJ
dpc-5458	25	24	is	be	AUX
dpc-5458	25	25	particularly	particularly	ADV
dpc-5458	25	26	indicated	indicate	VERB
dpc-5458	25	27	in	in	ADP
dpc-5458	25	28	patients	patient	NOUN
dpc-5458	25	29	with	with	ADP
dpc-5458	25	30	psoriatic	psoriatic	ADJ
dpc-5458	25	31	arthritis	arthritis	NOUN
dpc-5458	25	32	or	or	CCONJ
dpc-5458	25	33	systemic	systemic	ADJ
dpc-5458	25	34	inflammation	inflammation	NOUN
dpc-5458	25	35	.	.	PUNCT
dpc-5458	26	1	with	with	ADP
dpc-5458	26	2	over	over	ADP
dpc-5458	26	3	50	50	NUM
dpc-5458	26	4	years	year	NOUN
dpc-5458	26	5	of	of	ADP
dpc-5458	26	6	clinical	clinical	ADJ
dpc-5458	26	7	use	use	NOUN
dpc-5458	26	8	,	,	PUNCT
dpc-5458	26	9	it	it	PRON
dpc-5458	26	10	is	be	AUX
dpc-5458	26	11	suitable	suitable	ADJ
dpc-5458	26	12	for	for	ADP
dpc-5458	26	13	long	long	ADJ
dpc-5458	26	14	-	-	PUNCT
dpc-5458	26	15	term	term	NOUN
dpc-5458	26	16	management	management	NOUN
dpc-5458	26	17	and	and	CCONJ
dpc-5458	26	18	is	be	AUX
dpc-5458	26	19	supported	support	VERB
dpc-5458	26	20	by	by	ADP
dpc-5458	26	21	solid	solid	ADJ
dpc-5458	26	22	efficacy	efficacy	NOUN
dpc-5458	26	23	evidence	evidence	NOUN
dpc-5458	26	24	[	[	X
dpc-5458	26	25	10,11	10,11	NOUN
dpc-5458	26	26	]	]	PUNCT
dpc-5458	26	27	.	.	PUNCT
dpc-5458	27	1	mtx	mtx	NOUN
dpc-5458	27	2	's	's	PART
dpc-5458	27	3	clinical	clinical	ADJ
dpc-5458	27	4	utility	utility	NOUN
dpc-5458	27	5	is	be	AUX
dpc-5458	27	6	reinforced	reinforce	VERB
dpc-5458	27	7	by	by	ADP
dpc-5458	27	8	established	establish	VERB
dpc-5458	27	9	international	international	ADJ
dpc-5458	27	10	dosing	dosing	ADJ
dpc-5458	27	11	guidelines	guideline	NOUN
dpc-5458	27	12	and	and	CCONJ
dpc-5458	27	13	consensus	consensus	NOUN
dpc-5458	27	14	-	-	PUNCT
dpc-5458	27	15	based	base	VERB
dpc-5458	27	16	laboratory	laboratory	NOUN
dpc-5458	27	17	monitoring	monitoring	NOUN
dpc-5458	27	18	protocols	protocol	NOUN
dpc-5458	27	19	[	[	X
dpc-5458	27	20	12	12	NUM
dpc-5458	27	21	]	]	PUNCT
dpc-5458	27	22	.	.	PUNCT
dpc-5458	28	1	however	however	ADV
dpc-5458	28	2	,	,	PUNCT
dpc-5458	28	3	its	its	PRON
dpc-5458	28	4	use	use	NOUN
dpc-5458	28	5	is	be	AUX
dpc-5458	28	6	burdened	burden	VERB
dpc-5458	28	7	by	by	ADP
dpc-5458	28	8	several	several	ADJ
dpc-5458	28	9	drug	drug	NOUN
dpc-5458	28	10	interactions	interaction	NOUN
dpc-5458	28	11	and	and	CCONJ
dpc-5458	28	12	potentially	potentially	ADV
dpc-5458	28	13	severe	severe	ADJ
dpc-5458	28	14	adverse	adverse	ADJ
dpc-5458	28	15	events	event	NOUN
dpc-5458	28	16	such	such	ADJ
dpc-5458	28	17	as	as	ADP
dpc-5458	28	18	hepatotoxicity	hepatotoxicity	NOUN
dpc-5458	28	19	and	and	CCONJ
dpc-5458	28	20	myelosuppression	myelosuppression	NOUN
dpc-5458	28	21	[	[	X
dpc-5458	28	22	2	2	NUM
dpc-5458	28	23	]	]	PUNCT
dpc-5458	28	24	.	.	PUNCT
dpc-5458	29	1	cyclosporin	cyclosporin	NOUN
dpc-5458	29	2	,	,	PUNCT
dpc-5458	29	3	on	on	ADP
dpc-5458	29	4	the	the	DET
dpc-5458	29	5	other	other	ADJ
dpc-5458	29	6	hand	hand	NOUN
dpc-5458	29	7	,	,	PUNCT
dpc-5458	29	8	is	be	AUX
dpc-5458	29	9	particularly	particularly	ADV
dpc-5458	29	10	useful	useful	ADJ
dpc-5458	29	11	for	for	ADP
dpc-5458	29	12	severe	severe	ADJ
dpc-5458	29	13	and	and	CCONJ
dpc-5458	29	14	rapidly	rapidly	ADV
dpc-5458	29	15	progressive	progressive	ADJ
dpc-5458	29	16	forms	form	NOUN
dpc-5458	29	17	of	of	ADP
dpc-5458	29	18	plaque	plaque	NOUN
dpc-5458	29	19	psoriasis	psoriasis	NOUN
dpc-5458	29	20	or	or	CCONJ
dpc-5458	29	21	for	for	ADP
dpc-5458	29	22	cases	case	NOUN
dpc-5458	29	23	requiring	require	VERB
dpc-5458	29	24	rapid	rapid	ADJ
dpc-5458	29	25	disease	disease	NOUN
dpc-5458	29	26	control	control	NOUN
dpc-5458	29	27	.	.	PUNCT
dpc-5458	30	1	it	it	PRON
dpc-5458	30	2	has	have	AUX
dpc-5458	30	3	also	also	ADV
dpc-5458	30	4	been	be	AUX
dpc-5458	30	5	used	use	VERB
dpc-5458	30	6	in	in	ADP
dpc-5458	30	7	non	non	ADJ
dpc-5458	30	8	-	-	ADJ
dpc-5458	30	9	plaque	plaque	ADJ
dpc-5458	30	10	variants	variant	NOUN
dpc-5458	30	11	such	such	ADJ
dpc-5458	30	12	as	as	ADP
dpc-5458	30	13	pustular	pustular	ADJ
dpc-5458	30	14	or	or	CCONJ
dpc-5458	30	15	erythrodermic	erythrodermic	ADJ
dpc-5458	30	16	psoriasis	psoriasis	NOUN
dpc-5458	30	17	.	.	PUNCT
dpc-5458	31	1	its	its	PRON
dpc-5458	31	2	fast	fast	ADJ
dpc-5458	31	3	onset	onset	NOUN
dpc-5458	31	4	of	of	ADP
dpc-5458	31	5	action	action	NOUN
dpc-5458	31	6	makes	make	VERB
dpc-5458	31	7	it	it	PRON
dpc-5458	31	8	valuable	valuable	ADJ
dpc-5458	31	9	as	as	ADP
dpc-5458	31	10	a	a	DET
dpc-5458	31	11	short	short	ADJ
dpc-5458	31	12	-	-	PUNCT
dpc-5458	31	13	term	term	NOUN
dpc-5458	31	14	induction	induction	NOUN
dpc-5458	31	15	therapy	therapy	NOUN
dpc-5458	31	16	,	,	PUNCT
dpc-5458	31	17	particularly	particularly	ADV
dpc-5458	31	18	in	in	ADP
dpc-5458	31	19	adults	adult	NOUN
dpc-5458	31	20	without	without	ADP
dpc-5458	31	21	renal	renal	ADJ
dpc-5458	31	22	or	or	CCONJ
dpc-5458	31	23	cardiovascular	cardiovascular	ADJ
dpc-5458	31	24	contraindications	contraindication	NOUN
dpc-5458	31	25	[	[	X
dpc-5458	31	26	13	13	NUM
dpc-5458	31	27	]	]	PUNCT
dpc-5458	31	28	.	.	PUNCT
dpc-5458	32	1	while	while	SCONJ
dpc-5458	32	2	effective	effective	ADJ
dpc-5458	32	3	,	,	PUNCT
dpc-5458	32	4	its	its	PRON
dpc-5458	32	5	long	long	ADJ
dpc-5458	32	6	-	-	PUNCT
dpc-5458	32	7	term	term	NOUN
dpc-5458	32	8	use	use	NOUN
dpc-5458	32	9	is	be	AUX
dpc-5458	32	10	limited	limit	VERB
dpc-5458	32	11	by	by	ADP
dpc-5458	32	12	nephrotoxicity	nephrotoxicity	NOUN
dpc-5458	32	13	and	and	CCONJ
dpc-5458	32	14	other	other	ADJ
dpc-5458	32	15	metabolic	metabolic	ADJ
dpc-5458	32	16	side	side	NOUN
dpc-5458	32	17	effects	effect	NOUN
dpc-5458	32	18	[	[	X
dpc-5458	32	19	12	12	NUM
dpc-5458	32	20	]	]	PUNCT
dpc-5458	32	21	.	.	PUNCT
dpc-5458	33	1	acitretin	acitretin	PROPN
dpc-5458	33	2	is	be	AUX
dpc-5458	33	3	mainly	mainly	ADV
dpc-5458	33	4	indicated	indicate	VERB
dpc-5458	33	5	for	for	ADP
dpc-5458	33	6	palmoplantar	palmoplantar	NOUN
dpc-5458	33	7	and	and	CCONJ
dpc-5458	33	8	erythrodermic	erythrodermic	ADJ
dpc-5458	33	9	psoriasis	psoriasis	NOUN
dpc-5458	33	10	,	,	PUNCT
dpc-5458	33	11	where	where	SCONJ
dpc-5458	33	12	its	its	PRON
dpc-5458	33	13	systemic	systemic	ADJ
dpc-5458	33	14	retinoid	retinoid	NOUN
dpc-5458	33	15	action	action	NOUN
dpc-5458	33	16	provides	provide	VERB
dpc-5458	33	17	significant	significant	ADJ
dpc-5458	33	18	therapeutic	therapeutic	ADJ
dpc-5458	33	19	benefit	benefit	NOUN
dpc-5458	33	20	.	.	PUNCT
dpc-5458	34	1	its	its	PRON
dpc-5458	34	2	oral	oral	ADJ
dpc-5458	34	3	formulation	formulation	NOUN
dpc-5458	34	4	and	and	CCONJ
dpc-5458	34	5	efficacy	efficacy	NOUN
dpc-5458	34	6	in	in	ADP
dpc-5458	34	7	chronic	chronic	ADJ
dpc-5458	34	8	or	or	CCONJ
dpc-5458	34	9	treatment	treatment	NOUN
dpc-5458	34	10	-	-	PUNCT
dpc-5458	34	11	resistant	resistant	ADJ
dpc-5458	34	12	cases	case	NOUN
dpc-5458	34	13	further	far	ADV
dpc-5458	34	14	support	support	VERB
dpc-5458	34	15	its	its	PRON
dpc-5458	34	16	role	role	NOUN
dpc-5458	34	17	across	across	ADP
dpc-5458	34	18	various	various	ADJ
dpc-5458	34	19	psoriasis	psoriasis	NOUN
dpc-5458	34	20	subtypes	subtype	NOUN
dpc-5458	34	21	[	[	X
dpc-5458	34	22	14	14	NUM
dpc-5458	34	23	]	]	PUNCT
dpc-5458	34	24	.	.	PUNCT
dpc-5458	35	1	it	it	PRON
dpc-5458	35	2	is	be	AUX
dpc-5458	35	3	contraindicated	contraindicate	VERB
dpc-5458	35	4	in	in	ADP
dpc-5458	35	5	women	woman	NOUN
dpc-5458	35	6	of	of	ADP
dpc-5458	35	7	childbearing	childbeare	VERB
dpc-5458	35	8	potential	potential	NOUN
dpc-5458	35	9	due	due	ADP
dpc-5458	35	10	to	to	ADP
dpc-5458	35	11	its	its	PRON
dpc-5458	35	12	prolonged	prolonged	ADJ
dpc-5458	35	13	teratogenicity	teratogenicity	NOUN
dpc-5458	35	14	[	[	X
dpc-5458	35	15	15,16	15,16	NUM
dpc-5458	35	16	]	]	PUNCT
dpc-5458	35	17	.	.	PUNCT
dpc-5458	36	1	acitretin	acitretin	PROPN
dpc-5458	36	2	’s	’s	PART
dpc-5458	36	3	longstanding	longstanding	ADJ
dpc-5458	36	4	use	use	NOUN
dpc-5458	36	5	in	in	ADP
dpc-5458	36	6	europe	europe	PROPN
dpc-5458	36	7	underscores	underscore	VERB
dpc-5458	36	8	its	its	PRON
dpc-5458	36	9	utility	utility	NOUN
dpc-5458	36	10	in	in	ADP
dpc-5458	36	11	managing	manage	VERB
dpc-5458	36	12	difficult	difficult	ADJ
dpc-5458	36	13	-	-	PUNCT
dpc-5458	36	14	to	to	ADP
dpc-5458	36	15	-	-	PUNCT
dpc-5458	36	16	treat	treat	VERB
dpc-5458	36	17	cases	case	NOUN
dpc-5458	36	18	and	and	CCONJ
dpc-5458	36	19	introduction	introduction	NOUN
dpc-5458	36	20	:	:	PUNCT
dpc-5458	36	21	dimethyl	dimethyl	NOUN
dpc-5458	36	22	fumarate	fumarate	NOUN
dpc-5458	36	23	(	(	PUNCT
dpc-5458	36	24	dmf	dmf	PROPN
dpc-5458	36	25	)	)	PUNCT
dpc-5458	36	26	is	be	AUX
dpc-5458	36	27	an	an	DET
dpc-5458	36	28	approved	approve	VERB
dpc-5458	36	29	conventional	conventional	ADJ
dpc-5458	36	30	systemic	systemic	ADJ
dpc-5458	36	31	treatment	treatment	NOUN
dpc-5458	36	32	for	for	ADP
dpc-5458	36	33	psoriasis	psoriasis	NOUN
dpc-5458	36	34	that	that	PRON
dpc-5458	36	35	does	do	AUX
dpc-5458	36	36	not	not	PART
dpc-5458	36	37	exhibit	exhibit	VERB
dpc-5458	36	38	any	any	DET
dpc-5458	36	39	drug	drug	NOUN
dpc-5458	36	40	–	–	PUNCT
dpc-5458	36	41	drug	drug	NOUN
dpc-5458	36	42	interactions	interaction	NOUN
dpc-5458	36	43	or	or	CCONJ
dpc-5458	36	44	cumulative	cumulative	ADJ
dpc-5458	36	45	organ	organ	NOUN
dpc-5458	36	46	toxicities	toxicity	NOUN
dpc-5458	36	47	.	.	PUNCT
dpc-5458	37	1	aim	aim	NOUN
dpc-5458	37	2	:	:	PUNCT
dpc-5458	37	3	this	this	DET
dpc-5458	37	4	retrospective	retrospective	ADJ
dpc-5458	37	5	real	real	ADJ
dpc-5458	37	6	-	-	PUNCT
dpc-5458	37	7	world	world	NOUN
dpc-5458	37	8	study	study	NOUN
dpc-5458	37	9	aimed	aim	VERB
dpc-5458	37	10	to	to	PART
dpc-5458	37	11	analyze	analyze	VERB
dpc-5458	37	12	the	the	DET
dpc-5458	37	13	long	long	ADJ
dpc-5458	37	14	-	-	PUNCT
dpc-5458	37	15	term	term	NOUN
dpc-5458	37	16	efficacy	efficacy	NOUN
dpc-5458	37	17	,	,	PUNCT
dpc-5458	37	18	safety	safety	NOUN
dpc-5458	37	19	,	,	PUNCT
dpc-5458	37	20	and	and	CCONJ
dpc-5458	37	21	tolerability	tolerability	NOUN
dpc-5458	37	22	of	of	ADP
dpc-5458	37	23	dmf	dmf	PROPN
dpc-5458	37	24	in	in	ADP
dpc-5458	37	25	patients	patient	NOUN
dpc-5458	37	26	with	with	ADP
dpc-5458	37	27	moderate	moderate	ADJ
dpc-5458	37	28	psoriasis	psoriasis	NOUN
dpc-5458	37	29	.	.	PUNCT
dpc-5458	38	1	methods	method	NOUN
dpc-5458	38	2	:	:	PUNCT
dpc-5458	38	3	data	datum	NOUN
dpc-5458	38	4	on	on	ADP
dpc-5458	38	5	safety	safety	NOUN
dpc-5458	38	6	and	and	CCONJ
dpc-5458	38	7	efficacy	efficacy	NOUN
dpc-5458	38	8	were	be	AUX
dpc-5458	38	9	collected	collect	VERB
dpc-5458	38	10	from	from	ADP
dpc-5458	38	11	medical	medical	ADJ
dpc-5458	38	12	charts	chart	NOUN
dpc-5458	38	13	.	.	PUNCT
dpc-5458	39	1	the	the	DET
dpc-5458	39	2	effect	effect	NOUN
dpc-5458	39	3	on	on	ADP
dpc-5458	39	4	disease	disease	NOUN
dpc-5458	39	5	severity	severity	NOUN
dpc-5458	39	6	was	be	AUX
dpc-5458	39	7	assessed	assess	VERB
dpc-5458	39	8	using	use	VERB
dpc-5458	39	9	the	the	DET
dpc-5458	39	10	psoriasis	psoriasis	NOUN
dpc-5458	39	11	area	area	NOUN
dpc-5458	39	12	severity	severity	PROPN
dpc-5458	39	13	index	index	NOUN
dpc-5458	39	14	.	.	PUNCT
dpc-5458	40	1	results	result	NOUN
dpc-5458	40	2	:	:	PUNCT
dpc-5458	40	3	our	our	PRON
dpc-5458	40	4	study	study	NOUN
dpc-5458	40	5	included	include	VERB
dpc-5458	40	6	148	148	NUM
dpc-5458	40	7	patients	patient	NOUN
dpc-5458	40	8	over	over	ADP
dpc-5458	40	9	a	a	DET
dpc-5458	40	10	48	48	NUM
dpc-5458	40	11	-	-	PUNCT
dpc-5458	40	12	week	week	NOUN
dpc-5458	40	13	treatment	treatment	NOUN
dpc-5458	40	14	period	period	NOUN
dpc-5458	40	15	,	,	PUNCT
dpc-5458	40	16	confirming	confirm	VERB
dpc-5458	40	17	dmf	dmf	PROPN
dpc-5458	40	18	as	as	ADP
dpc-5458	40	19	an	an	DET
dpc-5458	40	20	effective	effective	ADJ
dpc-5458	40	21	option	option	NOUN
dpc-5458	40	22	in	in	ADP
dpc-5458	40	23	the	the	DET
dpc-5458	40	24	treatment	treatment	NOUN
dpc-5458	40	25	of	of	ADP
dpc-5458	40	26	moderate	moderate	ADJ
dpc-5458	40	27	psoriasis	psoriasis	NOUN
dpc-5458	40	28	.	.	PUNCT
dpc-5458	41	1	adverse	adverse	ADJ
dpc-5458	41	2	events	event	NOUN
dpc-5458	41	3	were	be	AUX
dpc-5458	41	4	only	only	ADV
dpc-5458	41	5	mild	mild	ADJ
dpc-5458	41	6	or	or	CCONJ
dpc-5458	41	7	moderate	moderate	ADJ
dpc-5458	41	8	,	,	PUNCT
dpc-5458	41	9	principally	principally	ADV
dpc-5458	41	10	flushing	flush	VERB
dpc-5458	41	11	,	,	PUNCT
dpc-5458	41	12	epigastralgia	epigastralgia	ADJ
dpc-5458	41	13	,	,	PUNCT
dpc-5458	41	14	and	and	CCONJ
dpc-5458	41	15	diarrhea	diarrhea	NOUN
dpc-5458	41	16	.	.	PUNCT
dpc-5458	42	1	however	however	ADV
dpc-5458	42	2	,	,	PUNCT
dpc-5458	42	3	dmf	dmf	PROPN
dpc-5458	42	4	exhibited	exhibit	VERB
dpc-5458	42	5	a	a	DET
dpc-5458	42	6	delayed	delay	VERB
dpc-5458	42	7	onset	onset	NOUN
dpc-5458	42	8	of	of	ADP
dpc-5458	42	9	action	action	NOUN
dpc-5458	42	10	,	,	PUNCT
dpc-5458	42	11	and	and	CCONJ
dpc-5458	42	12	the	the	DET
dpc-5458	42	13	dropout	dropout	NOUN
dpc-5458	42	14	rate	rate	NOUN
dpc-5458	42	15	was	be	AUX
dpc-5458	42	16	high	high	ADJ
dpc-5458	42	17	.	.	PUNCT
dpc-5458	43	1	these	these	DET
dpc-5458	43	2	aspects	aspect	NOUN
dpc-5458	43	3	highlight	highlight	VERB
dpc-5458	43	4	the	the	DET
dpc-5458	43	5	importance	importance	NOUN
dpc-5458	43	6	of	of	ADP
dpc-5458	43	7	educating	educate	VERB
dpc-5458	43	8	patients	patient	NOUN
dpc-5458	43	9	about	about	ADP
dpc-5458	43	10	the	the	DET
dpc-5458	43	11	activity	activity	NOUN
dpc-5458	43	12	profile	profile	NOUN
dpc-5458	43	13	of	of	ADP
dpc-5458	43	14	dmf	dmf	PROPN
dpc-5458	43	15	,	,	PUNCT
dpc-5458	43	16	the	the	DET
dpc-5458	43	17	potential	potential	ADJ
dpc-5458	43	18	occurrence	occurrence	NOUN
dpc-5458	43	19	of	of	ADP
dpc-5458	43	20	side	side	NOUN
dpc-5458	43	21	effects	effect	NOUN
dpc-5458	43	22	,	,	PUNCT
dpc-5458	43	23	and	and	CCONJ
dpc-5458	43	24	their	their	PRON
dpc-5458	43	25	management	management	NOUN
dpc-5458	43	26	.	.	PUNCT
dpc-5458	44	1	however	however	ADV
dpc-5458	44	2	,	,	PUNCT
dpc-5458	44	3	side	side	ADJ
dpc-5458	44	4	effects	effect	NOUN
dpc-5458	44	5	are	be	AUX
dpc-5458	44	6	self	self	NOUN
dpc-5458	44	7	-	-	PUNCT
dpc-5458	44	8	limiting	limit	VERB
dpc-5458	44	9	with	with	ADP
dpc-5458	44	10	discontinuation	discontinuation	NOUN
dpc-5458	44	11	of	of	ADP
dpc-5458	44	12	treatment	treatment	NOUN
dpc-5458	44	13	and	and	CCONJ
dpc-5458	44	14	generally	generally	ADV
dpc-5458	44	15	occur	occur	VERB
dpc-5458	44	16	early	early	ADV
dpc-5458	44	17	,	,	PUNCT
dpc-5458	44	18	allowing	allow	VERB
dpc-5458	44	19	patients	patient	NOUN
dpc-5458	44	20	to	to	PART
dpc-5458	44	21	be	be	AUX
dpc-5458	44	22	promptly	promptly	ADV
dpc-5458	44	23	switched	switch	VERB
dpc-5458	44	24	to	to	ADP
dpc-5458	44	25	other	other	ADJ
dpc-5458	44	26	therapies	therapy	NOUN
dpc-5458	44	27	if	if	SCONJ
dpc-5458	44	28	dmf	dmf	PROPN
dpc-5458	44	29	is	be	AUX
dpc-5458	44	30	not	not	PART
dpc-5458	44	31	tolerated	tolerate	VERB
dpc-5458	44	32	.	.	PUNCT
dpc-5458	45	1	conclusions	conclusion	NOUN
dpc-5458	45	2	:	:	PUNCT
dpc-5458	45	3	our	our	PRON
dpc-5458	45	4	results	result	NOUN
dpc-5458	45	5	confirm	confirm	VERB
dpc-5458	45	6	that	that	SCONJ
dpc-5458	45	7	dmf	dmf	PROPN
dpc-5458	45	8	may	may	AUX
dpc-5458	45	9	be	be	AUX
dpc-5458	45	10	offered	offer	VERB
dpc-5458	45	11	as	as	ADP
dpc-5458	45	12	a	a	DET
dpc-5458	45	13	first	first	ADJ
dpc-5458	45	14	-	-	PUNCT
dpc-5458	45	15	line	line	NOUN
dpc-5458	45	16	treatment	treatment	NOUN
dpc-5458	45	17	for	for	ADP
dpc-5458	45	18	moderate	moderate	ADJ
dpc-5458	45	19	psoriasis	psoriasis	NOUN
dpc-5458	45	20	as	as	SCONJ
dpc-5458	45	21	it	it	PRON
dpc-5458	45	22	demonstrated	demonstrate	VERB
dpc-5458	45	23	efficacy	efficacy	NOUN
dpc-5458	45	24	even	even	ADV
dpc-5458	45	25	in	in	ADP
dpc-5458	45	26	the	the	DET
dpc-5458	45	27	long	long	ADJ
dpc-5458	45	28	-	-	PUNCT
dpc-5458	45	29	term	term	NOUN
dpc-5458	45	30	,	,	PUNCT
dpc-5458	45	31	when	when	SCONJ
dpc-5458	45	32	treatment	treatment	NOUN
dpc-5458	45	33	is	be	AUX
dpc-5458	45	34	tolerated	tolerate	VERB
dpc-5458	45	35	,	,	PUNCT
dpc-5458	45	36	especially	especially	ADV
dpc-5458	45	37	in	in	ADP
dpc-5458	45	38	patients	patient	NOUN
dpc-5458	45	39	with	with	ADP
dpc-5458	45	40	a	a	DET
dpc-5458	45	41	disease	disease	NOUN
dpc-5458	45	42	duration	duration	NOUN
dpc-5458	45	43	of	of	ADP
dpc-5458	45	44	less	less	ADJ
dpc-5458	45	45	than	than	ADP
dpc-5458	45	46	five	five	NUM
dpc-5458	45	47	years	year	NOUN
dpc-5458	45	48	.	.	PUNCT
dpc-5458	46	1	dmf	dmf	PROPN
dpc-5458	46	2	may	may	AUX
dpc-5458	46	3	also	also	ADV
dpc-5458	46	4	be	be	AUX
dpc-5458	46	5	proposed	propose	VERB
dpc-5458	46	6	when	when	SCONJ
dpc-5458	46	7	the	the	DET
dpc-5458	46	8	patient	patient	NOUN
dpc-5458	46	9	presents	present	NOUN
dpc-5458	46	10	comorbidities	comorbiditie	NOUN
dpc-5458	46	11	,	,	PUNCT
dpc-5458	46	12	when	when	SCONJ
dpc-5458	46	13	immunosuppression	immunosuppression	NOUN
dpc-5458	46	14	is	be	AUX
dpc-5458	46	15	undesired	undesired	ADJ
dpc-5458	46	16	,	,	PUNCT
dpc-5458	46	17	and/or	and/or	CCONJ
dpc-5458	46	18	before	before	ADP
dpc-5458	46	19	the	the	DET
dpc-5458	46	20	initiation	initiation	NOUN
dpc-5458	46	21	of	of	ADP
dpc-5458	46	22	biological	biological	ADJ
dpc-5458	46	23	therapies	therapy	NOUN
dpc-5458	46	24	.	.	PUNCT
dpc-5458	47	1	abstract	abstract	ADJ
dpc-5458	47	2	original	original	ADJ
dpc-5458	47	3	article	article	NOUN
dpc-5458	47	4	|	|	ADV
dpc-5458	47	5	dermatol	dermatol	ADJ
dpc-5458	47	6	pract	pract	NOUN
dpc-5458	47	7	concept	concept	NOUN
dpc-5458	47	8	.	.	PUNCT
dpc-5458	48	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	48	2	3	3	NUM
dpc-5458	48	3	keratinization	keratinization	NOUN
dpc-5458	48	4	disorders	disorder	NOUN
dpc-5458	48	5	.	.	PUNCT
dpc-5458	49	1	however	however	ADV
dpc-5458	49	2	,	,	PUNCT
dpc-5458	49	3	patient	patient	ADJ
dpc-5458	49	4	selection	selection	NOUN
dpc-5458	49	5	must	must	AUX
dpc-5458	49	6	account	account	VERB
dpc-5458	49	7	for	for	ADP
dpc-5458	49	8	lipid	lipid	ADJ
dpc-5458	49	9	metabolism	metabolism	NOUN
dpc-5458	49	10	and	and	CCONJ
dpc-5458	49	11	liver	liver	NOUN
dpc-5458	49	12	function	function	NOUN
dpc-5458	49	13	status	status	NOUN
dpc-5458	49	14	[	[	X
dpc-5458	49	15	12	12	NUM
dpc-5458	49	16	]	]	PUNCT
dpc-5458	49	17	.	.	PUNCT
dpc-5458	50	1	dimethyl	dimethyl	PROPN
dpc-5458	50	2	fumarate	fumarate	PROPN
dpc-5458	50	3	(	(	PUNCT
dpc-5458	50	4	dmf	dmf	PROPN
dpc-5458	50	5	)	)	PUNCT
dpc-5458	50	6	is	be	AUX
dpc-5458	50	7	an	an	DET
dpc-5458	50	8	fae	fae	NOUN
dpc-5458	50	9	with	with	ADP
dpc-5458	50	10	anti	anti	X
dpc-5458	50	11	inflammatory	inflammatory	ADJ
dpc-5458	50	12	and	and	CCONJ
dpc-5458	50	13	immunomodulating	immunomodulating	ADJ
dpc-5458	50	14	effects	effect	NOUN
dpc-5458	50	15	,	,	PUNCT
dpc-5458	50	16	approved	approve	VERB
dpc-5458	50	17	by	by	ADP
dpc-5458	50	18	the	the	DET
dpc-5458	50	19	european	european	PROPN
dpc-5458	50	20	medicines	medicines	PROPN
dpc-5458	50	21	agency	agency	NOUN
dpc-5458	50	22	(	(	PUNCT
dpc-5458	50	23	ema	ema	PROPN
dpc-5458	50	24	)	)	PUNCT
dpc-5458	50	25	for	for	ADP
dpc-5458	50	26	the	the	DET
dpc-5458	50	27	treatment	treatment	NOUN
dpc-5458	50	28	of	of	ADP
dpc-5458	50	29	patients	patient	NOUN
dpc-5458	50	30	with	with	ADP
dpc-5458	50	31	moderate	moderate	ADJ
dpc-5458	50	32	-	-	PUNCT
dpc-5458	50	33	to	to	ADP
dpc-5458	50	34	-	-	PUNCT
dpc-5458	50	35	severe	severe	ADJ
dpc-5458	50	36	plaque	plaque	NOUN
dpc-5458	50	37	psoriasis	psoriasis	NOUN
dpc-5458	50	38	since	since	SCONJ
dpc-5458	50	39	2017	2017	NUM
dpc-5458	50	40	[	[	X
dpc-5458	50	41	17,18	17,18	NUM
dpc-5458	50	42	]	]	PUNCT
dpc-5458	50	43	.	.	PUNCT
dpc-5458	51	1	regarding	regard	VERB
dpc-5458	51	2	dmf	dmf	PROPN
dpc-5458	51	3	efficacy	efficacy	PROPN
dpc-5458	51	4	,	,	PUNCT
dpc-5458	51	5	the	the	DET
dpc-5458	51	6	dimeskin-2	dimeskin-2	NUM
dpc-5458	51	7	trial	trial	NOUN
dpc-5458	51	8	reported	report	VERB
dpc-5458	51	9	pasi	pasi	NOUN
dpc-5458	51	10	75	75	NUM
dpc-5458	51	11	in	in	ADP
dpc-5458	51	12	81.1	81.1	NUM
dpc-5458	51	13	%	%	NOUN
dpc-5458	51	14	of	of	ADP
dpc-5458	51	15	patients	patient	NOUN
dpc-5458	51	16	at	at	ADP
dpc-5458	51	17	week	week	NOUN
dpc-5458	51	18	52	52	NUM
dpc-5458	51	19	[	[	X
dpc-5458	51	20	19	19	NUM
dpc-5458	51	21	]	]	PUNCT
dpc-5458	51	22	,	,	PUNCT
dpc-5458	51	23	and	and	CCONJ
dpc-5458	51	24	the	the	DET
dpc-5458	51	25	bridge	bridge	NOUN
dpc-5458	51	26	study	study	NOUN
dpc-5458	51	27	achieved	achieve	VERB
dpc-5458	51	28	pasi	pasi	NOUN
dpc-5458	51	29	75	75	NUM
dpc-5458	51	30	in	in	ADP
dpc-5458	51	31	37.5	37.5	NUM
dpc-5458	51	32	%	%	NOUN
dpc-5458	51	33	of	of	ADP
dpc-5458	51	34	patients	patient	NOUN
dpc-5458	51	35	at	at	ADP
dpc-5458	51	36	week	week	NOUN
dpc-5458	51	37	16	16	NUM
dpc-5458	52	1	[	[	X
dpc-5458	52	2	20	20	NUM
dpc-5458	52	3	]	]	PUNCT
dpc-5458	52	4	.	.	PUNCT
dpc-5458	53	1	in	in	ADP
dpc-5458	53	2	a	a	DET
dpc-5458	53	3	real	real	ADJ
dpc-5458	53	4	-	-	PUNCT
dpc-5458	53	5	world	world	NOUN
dpc-5458	53	6	multicenter	multicenter	NOUN
dpc-5458	53	7	study	study	NOUN
dpc-5458	53	8	,	,	PUNCT
dpc-5458	53	9	pasi	pasi	NOUN
dpc-5458	53	10	75	75	NUM
dpc-5458	53	11	was	be	AUX
dpc-5458	53	12	achieved	achieve	VERB
dpc-5458	53	13	in	in	ADP
dpc-5458	53	14	23.3	23.3	NUM
dpc-5458	53	15	%	%	NOUN
dpc-5458	53	16	of	of	ADP
dpc-5458	53	17	patients	patient	NOUN
dpc-5458	53	18	at	at	ADP
dpc-5458	53	19	week	week	NOUN
dpc-5458	53	20	12	12	NUM
dpc-5458	53	21	,	,	PUNCT
dpc-5458	53	22	with	with	ADP
dpc-5458	53	23	a	a	DET
dpc-5458	53	24	further	further	ADJ
dpc-5458	53	25	17.4	17.4	NUM
dpc-5458	53	26	%	%	NOUN
dpc-5458	53	27	reaching	reach	VERB
dpc-5458	53	28	it	it	PRON
dpc-5458	53	29	by	by	ADP
dpc-5458	53	30	week	week	NOUN
dpc-5458	53	31	26	26	NUM
dpc-5458	53	32	.	.	PUNCT
dpc-5458	54	1	side	side	NOUN
dpc-5458	54	2	effects	effect	NOUN
dpc-5458	54	3	occurred	occur	VERB
dpc-5458	54	4	in	in	ADP
dpc-5458	54	5	61.1	61.1	NUM
dpc-5458	54	6	%	%	NOUN
dpc-5458	54	7	of	of	ADP
dpc-5458	54	8	patients	patient	NOUN
dpc-5458	54	9	,	,	PUNCT
dpc-5458	54	10	with	with	ADP
dpc-5458	54	11	the	the	DET
dpc-5458	54	12	most	most	ADV
dpc-5458	54	13	common	common	ADJ
dpc-5458	54	14	being	being	NOUN
dpc-5458	54	15	diarrhea	diarrhea	NOUN
dpc-5458	54	16	,	,	PUNCT
dpc-5458	54	17	epigastric	epigastric	NOUN
dpc-5458	54	18	discomfort	discomfort	NOUN
dpc-5458	54	19	,	,	PUNCT
dpc-5458	54	20	nausea	nausea	NOUN
dpc-5458	54	21	,	,	PUNCT
dpc-5458	54	22	and	and	CCONJ
dpc-5458	54	23	flushing	flush	VERB
dpc-5458	54	24	.	.	PUNCT
dpc-5458	55	1	however	however	ADV
dpc-5458	55	2	,	,	PUNCT
dpc-5458	55	3	dmf	dmf	PROPN
dpc-5458	55	4	does	do	AUX
dpc-5458	55	5	not	not	PART
dpc-5458	55	6	display	display	VERB
dpc-5458	55	7	major	major	ADJ
dpc-5458	55	8	contraindications	contraindication	NOUN
dpc-5458	55	9	[	[	X
dpc-5458	55	10	21	21	NUM
dpc-5458	55	11	]	]	PUNCT
dpc-5458	55	12	.	.	PUNCT
dpc-5458	56	1	despite	despite	SCONJ
dpc-5458	56	2	these	these	DET
dpc-5458	56	3	considerations	consideration	NOUN
dpc-5458	56	4	,	,	PUNCT
dpc-5458	56	5	dmf	dmf	PROPN
dpc-5458	56	6	is	be	AUX
dpc-5458	56	7	still	still	ADV
dpc-5458	56	8	infrequently	infrequently	ADV
dpc-5458	56	9	prescribed	prescribe	VERB
dpc-5458	56	10	for	for	ADP
dpc-5458	56	11	psoriasis	psoriasis	NOUN
dpc-5458	56	12	treatment	treatment	NOUN
dpc-5458	56	13	,	,	PUNCT
dpc-5458	56	14	and	and	CCONJ
dpc-5458	56	15	real	real	ADJ
dpc-5458	56	16	-	-	PUNCT
dpc-5458	56	17	life	life	NOUN
dpc-5458	56	18	evidence	evidence	NOUN
dpc-5458	56	19	on	on	ADP
dpc-5458	56	20	its	its	PRON
dpc-5458	56	21	use	use	NOUN
dpc-5458	56	22	is	be	AUX
dpc-5458	56	23	scarce	scarce	ADJ
dpc-5458	56	24	.	.	PUNCT
dpc-5458	57	1	we	we	PRON
dpc-5458	57	2	report	report	VERB
dpc-5458	57	3	the	the	DET
dpc-5458	57	4	results	result	NOUN
dpc-5458	57	5	from	from	ADP
dpc-5458	57	6	an	an	DET
dpc-5458	57	7	italian	italian	ADJ
dpc-5458	57	8	multicenter	multicenter	NOUN
dpc-5458	57	9	retrospective	retrospective	ADJ
dpc-5458	57	10	study	study	NOUN
dpc-5458	57	11	on	on	ADP
dpc-5458	57	12	the	the	DET
dpc-5458	57	13	use	use	NOUN
dpc-5458	57	14	of	of	ADP
dpc-5458	57	15	dmf	dmf	PROPN
dpc-5458	57	16	.	.	PUNCT
dpc-5458	57	17	objectives	objective	VERB
dpc-5458	57	18	the	the	DET
dpc-5458	57	19	objective	objective	NOUN
dpc-5458	57	20	of	of	ADP
dpc-5458	57	21	this	this	DET
dpc-5458	57	22	study	study	NOUN
dpc-5458	57	23	was	be	AUX
dpc-5458	57	24	to	to	PART
dpc-5458	57	25	evaluate	evaluate	VERB
dpc-5458	57	26	the	the	DET
dpc-5458	57	27	long	long	ADJ
dpc-5458	57	28	-	-	PUNCT
dpc-5458	57	29	term	term	NOUN
dpc-5458	57	30	efficacy	efficacy	NOUN
dpc-5458	57	31	,	,	PUNCT
dpc-5458	57	32	safety	safety	NOUN
dpc-5458	57	33	,	,	PUNCT
dpc-5458	57	34	and	and	CCONJ
dpc-5458	57	35	tolerability	tolerability	NOUN
dpc-5458	57	36	of	of	ADP
dpc-5458	57	37	dmf	dmf	PROPN
dpc-5458	57	38	in	in	ADP
dpc-5458	57	39	a	a	DET
dpc-5458	57	40	real	real	ADJ
dpc-5458	57	41	-	-	PUNCT
dpc-5458	57	42	world	world	NOUN
dpc-5458	57	43	clinical	clinical	ADJ
dpc-5458	57	44	setting	setting	NOUN
dpc-5458	57	45	focused	focus	VERB
dpc-5458	57	46	on	on	ADP
dpc-5458	57	47	moderate	moderate	ADJ
dpc-5458	57	48	forms	form	NOUN
dpc-5458	57	49	of	of	ADP
dpc-5458	57	50	the	the	DET
dpc-5458	57	51	disease	disease	NOUN
dpc-5458	57	52	.	.	PUNCT
dpc-5458	58	1	the	the	DET
dpc-5458	58	2	study	study	NOUN
dpc-5458	58	3	aimed	aim	VERB
dpc-5458	58	4	to	to	PART
dpc-5458	58	5	assess	assess	VERB
dpc-5458	58	6	the	the	DET
dpc-5458	58	7	achievement	achievement	NOUN
dpc-5458	58	8	of	of	ADP
dpc-5458	58	9	disease	disease	NOUN
dpc-5458	58	10	severity	severity	NOUN
dpc-5458	58	11	reduction	reduction	NOUN
dpc-5458	58	12	of	of	ADP
dpc-5458	58	13	50	50	NUM
dpc-5458	58	14	%	%	NOUN
dpc-5458	58	15	or	or	CCONJ
dpc-5458	58	16	75	75	NUM
dpc-5458	58	17	%	%	NOUN
dpc-5458	58	18	(	(	PUNCT
dpc-5458	58	19	pasi	pasi	NOUN
dpc-5458	58	20	50	50	NUM
dpc-5458	58	21	and	and	CCONJ
dpc-5458	58	22	pasi	pasi	NOUN
dpc-5458	58	23	75	75	NUM
dpc-5458	58	24	)	)	PUNCT
dpc-5458	58	25	,	,	PUNCT
dpc-5458	58	26	treatment	treatment	NOUN
dpc-5458	58	27	retention	retention	NOUN
dpc-5458	58	28	rates	rate	NOUN
dpc-5458	58	29	,	,	PUNCT
dpc-5458	58	30	and	and	CCONJ
dpc-5458	58	31	the	the	DET
dpc-5458	58	32	occurrence	occurrence	NOUN
dpc-5458	58	33	of	of	ADP
dpc-5458	58	34	adverse	adverse	ADJ
dpc-5458	58	35	events	event	NOUN
dpc-5458	58	36	over	over	ADP
dpc-5458	58	37	48	48	NUM
dpc-5458	58	38	weeks	week	NOUN
dpc-5458	58	39	.	.	PUNCT
dpc-5458	59	1	this	this	DET
dpc-5458	59	2	work	work	NOUN
dpc-5458	59	3	may	may	AUX
dpc-5458	59	4	thus	thus	ADV
dpc-5458	59	5	help	help	VERB
dpc-5458	59	6	clarify	clarify	VERB
dpc-5458	59	7	the	the	DET
dpc-5458	59	8	role	role	NOUN
dpc-5458	59	9	of	of	ADP
dpc-5458	59	10	dmf	dmf	PROPN
dpc-5458	59	11	as	as	ADP
dpc-5458	59	12	firstline	firstline	PROPN
dpc-5458	59	13	systemic	systemic	ADJ
dpc-5458	59	14	therapy	therapy	NOUN
dpc-5458	59	15	,	,	PUNCT
dpc-5458	59	16	especially	especially	ADV
dpc-5458	59	17	for	for	ADP
dpc-5458	59	18	patients	patient	NOUN
dpc-5458	59	19	with	with	ADP
dpc-5458	59	20	early	early	ADJ
dpc-5458	59	21	-	-	PUNCT
dpc-5458	59	22	stage	stage	NOUN
dpc-5458	59	23	disease	disease	NOUN
dpc-5458	59	24	and	and	CCONJ
dpc-5458	59	25	significant	significant	ADJ
dpc-5458	59	26	comorbidities	comorbiditie	NOUN
dpc-5458	59	27	.	.	PUNCT
dpc-5458	60	1	patients	patient	NOUN
dpc-5458	60	2	and	and	CCONJ
dpc-5458	60	3	methods	method	NOUN
dpc-5458	60	4	study	study	NOUN
dpc-5458	60	5	design	design	NOUN
dpc-5458	60	6	this	this	PRON
dpc-5458	60	7	was	be	AUX
dpc-5458	60	8	a	a	DET
dpc-5458	60	9	retrospective	retrospective	ADJ
dpc-5458	60	10	real	real	ADJ
dpc-5458	60	11	-	-	PUNCT
dpc-5458	60	12	world	world	NOUN
dpc-5458	60	13	study	study	NOUN
dpc-5458	60	14	conducted	conduct	VERB
dpc-5458	60	15	at	at	ADP
dpc-5458	60	16	the	the	DET
dpc-5458	60	17	departments	department	NOUN
dpc-5458	60	18	of	of	ADP
dpc-5458	60	19	dermatology	dermatology	NOUN
dpc-5458	60	20	of	of	ADP
dpc-5458	60	21	eight	eight	NUM
dpc-5458	60	22	university	university	NOUN
dpc-5458	60	23	referral	referral	NOUN
dpc-5458	60	24	centers	center	NOUN
dpc-5458	60	25	in	in	ADP
dpc-5458	60	26	italy	italy	PROPN
dpc-5458	60	27	(	(	PUNCT
dpc-5458	60	28	l’aquila	l’aquila	PROPN
dpc-5458	60	29	,	,	PUNCT
dpc-5458	60	30	firenze	firenze	NOUN
dpc-5458	60	31	,	,	PUNCT
dpc-5458	60	32	roma	roma	PROPN
dpc-5458	60	33	tor	tor	PROPN
dpc-5458	60	34	vergata	vergata	PROPN
dpc-5458	60	35	,	,	PUNCT
dpc-5458	60	36	genova	genova	PROPN
dpc-5458	60	37	,	,	PUNCT
dpc-5458	60	38	roma	roma	PROPN
dpc-5458	60	39	cattolica	cattolica	PROPN
dpc-5458	60	40	,	,	PUNCT
dpc-5458	60	41	roma	roma	PROPN
dpc-5458	60	42	ifo	ifo	PROPN
dpc-5458	60	43	,	,	PUNCT
dpc-5458	60	44	roma	roma	PROPN
dpc-5458	60	45	sapienza	sapienza	PROPN
dpc-5458	60	46	,	,	PUNCT
dpc-5458	60	47	ancona	ancona	NOUN
dpc-5458	60	48	)	)	PUNCT
dpc-5458	60	49	.	.	PUNCT
dpc-5458	61	1	all	all	DET
dpc-5458	61	2	subjects	subject	NOUN
dpc-5458	61	3	enrolled	enrol	VERB
dpc-5458	61	4	in	in	ADP
dpc-5458	61	5	the	the	DET
dpc-5458	61	6	study	study	NOUN
dpc-5458	61	7	received	receive	VERB
dpc-5458	61	8	dmf	dmf	PROPN
dpc-5458	61	9	according	accord	VERB
dpc-5458	61	10	to	to	ADP
dpc-5458	61	11	local	local	ADJ
dpc-5458	61	12	guidelines	guideline	NOUN
dpc-5458	61	13	and	and	CCONJ
dpc-5458	61	14	the	the	DET
dpc-5458	61	15	summary	summary	NOUN
dpc-5458	61	16	of	of	ADP
dpc-5458	61	17	product	product	NOUN
dpc-5458	61	18	characteristics	characteristic	NOUN
dpc-5458	61	19	.	.	PUNCT
dpc-5458	62	1	ethical	ethical	ADJ
dpc-5458	62	2	considerations	consideration	NOUN
dpc-5458	62	3	the	the	DET
dpc-5458	62	4	investigation	investigation	NOUN
dpc-5458	62	5	was	be	AUX
dpc-5458	62	6	conducted	conduct	VERB
dpc-5458	62	7	in	in	ADP
dpc-5458	62	8	accordance	accordance	NOUN
dpc-5458	62	9	with	with	ADP
dpc-5458	62	10	the	the	DET
dpc-5458	62	11	helsinki	helsinki	PROPN
dpc-5458	62	12	declaration	declaration	PROPN
dpc-5458	62	13	and	and	CCONJ
dpc-5458	62	14	later	later	ADJ
dpc-5458	62	15	amendments	amendment	NOUN
dpc-5458	62	16	,	,	PUNCT
dpc-5458	62	17	and	and	CCONJ
dpc-5458	62	18	patients	patient	NOUN
dpc-5458	62	19	signed	sign	VERB
dpc-5458	62	20	a	a	DET
dpc-5458	62	21	consent	consent	NOUN
dpc-5458	62	22	form	form	NOUN
dpc-5458	62	23	authorizing	authorize	VERB
dpc-5458	62	24	the	the	DET
dpc-5458	62	25	use	use	NOUN
dpc-5458	62	26	of	of	ADP
dpc-5458	62	27	their	their	PRON
dpc-5458	62	28	clinical	clinical	ADJ
dpc-5458	62	29	records	record	NOUN
dpc-5458	62	30	for	for	ADP
dpc-5458	62	31	scientific	scientific	ADJ
dpc-5458	62	32	purposes	purpose	NOUN
dpc-5458	62	33	.	.	PUNCT
dpc-5458	63	1	confidentiality	confidentiality	NOUN
dpc-5458	63	2	and	and	CCONJ
dpc-5458	63	3	privacy	privacy	NOUN
dpc-5458	63	4	of	of	ADP
dpc-5458	63	5	patient	patient	ADJ
dpc-5458	63	6	data	datum	NOUN
dpc-5458	63	7	are	be	AUX
dpc-5458	63	8	assured	assure	VERB
dpc-5458	63	9	by	by	ADP
dpc-5458	63	10	internal	internal	ADJ
dpc-5458	63	11	data	datum	NOUN
dpc-5458	63	12	protection	protection	NOUN
dpc-5458	63	13	regulations	regulation	NOUN
dpc-5458	63	14	as	as	ADV
dpc-5458	63	15	well	well	ADV
dpc-5458	63	16	as	as	ADP
dpc-5458	63	17	by	by	ADP
dpc-5458	63	18	the	the	DET
dpc-5458	63	19	general	general	ADJ
dpc-5458	63	20	data	data	PROPN
dpc-5458	63	21	protection	protection	NOUN
dpc-5458	63	22	regulation	regulation	NOUN
dpc-5458	63	23	(	(	PUNCT
dpc-5458	63	24	gdpr	gdpr	NOUN
dpc-5458	63	25	)	)	PUNCT
dpc-5458	63	26	(	(	PUNCT
dpc-5458	63	27	eu	eu	NOUN
dpc-5458	63	28	)	)	PUNCT
dpc-5458	63	29	2016/679	2016/679	NOUN
dpc-5458	63	30	.	.	PUNCT
dpc-5458	64	1	the	the	DET
dpc-5458	64	2	study	study	NOUN
dpc-5458	64	3	did	do	AUX
dpc-5458	64	4	not	not	PART
dpc-5458	64	5	require	require	VERB
dpc-5458	64	6	ethical	ethical	ADJ
dpc-5458	64	7	approval	approval	NOUN
dpc-5458	64	8	in	in	ADP
dpc-5458	64	9	accordance	accordance	NOUN
dpc-5458	64	10	with	with	ADP
dpc-5458	64	11	national	national	ADJ
dpc-5458	64	12	guidelines	guideline	NOUN
dpc-5458	64	13	.	.	PUNCT
dpc-5458	65	1	patients	patient	NOUN
dpc-5458	65	2	patients	patient	NOUN
dpc-5458	65	3	aged	age	VERB
dpc-5458	65	4	≥18	≥18	NUM
dpc-5458	65	5	years	year	NOUN
dpc-5458	65	6	with	with	ADP
dpc-5458	65	7	a	a	DET
dpc-5458	65	8	diagnosis	diagnosis	NOUN
dpc-5458	65	9	of	of	ADP
dpc-5458	65	10	moderate	moderate	ADJ
dpc-5458	65	11	psoriasis	psoriasis	NOUN
dpc-5458	65	12	who	who	PRON
dpc-5458	65	13	underwent	undergo	VERB
dpc-5458	65	14	dmf	dmf	PROPN
dpc-5458	65	15	treatment	treatment	NOUN
dpc-5458	65	16	for	for	ADP
dpc-5458	65	17	48	48	NUM
dpc-5458	65	18	weeks	week	NOUN
dpc-5458	65	19	between	between	ADP
dpc-5458	65	20	june	june	PROPN
dpc-5458	65	21	2022	2022	NUM
dpc-5458	65	22	and	and	CCONJ
dpc-5458	65	23	december	december	PROPN
dpc-5458	65	24	2023	2023	NUM
dpc-5458	65	25	,	,	PUNCT
dpc-5458	65	26	according	accord	VERB
dpc-5458	65	27	to	to	ADP
dpc-5458	65	28	standard	standard	ADJ
dpc-5458	65	29	clinical	clinical	ADJ
dpc-5458	65	30	practice	practice	NOUN
dpc-5458	65	31	,	,	PUNCT
dpc-5458	65	32	were	be	AUX
dpc-5458	65	33	enrolled	enrol	VERB
dpc-5458	65	34	in	in	ADP
dpc-5458	65	35	the	the	DET
dpc-5458	65	36	study	study	NOUN
dpc-5458	65	37	.	.	PUNCT
dpc-5458	66	1	data	datum	NOUN
dpc-5458	66	2	collection	collection	NOUN
dpc-5458	66	3	demographic	demographic	ADJ
dpc-5458	66	4	and	and	CCONJ
dpc-5458	66	5	disease	disease	NOUN
dpc-5458	66	6	variables	variable	NOUN
dpc-5458	66	7	,	,	PUNCT
dpc-5458	66	8	such	such	ADJ
dpc-5458	66	9	as	as	ADP
dpc-5458	66	10	age	age	NOUN
dpc-5458	66	11	,	,	PUNCT
dpc-5458	66	12	sex	sex	NOUN
dpc-5458	66	13	,	,	PUNCT
dpc-5458	66	14	weight	weight	NOUN
dpc-5458	66	15	,	,	PUNCT
dpc-5458	66	16	body	body	NOUN
dpc-5458	66	17	mass	mass	NOUN
dpc-5458	66	18	index	index	NOUN
dpc-5458	66	19	(	(	PUNCT
dpc-5458	66	20	bmi	bmi	PROPN
dpc-5458	66	21	)	)	PUNCT
dpc-5458	66	22	,	,	PUNCT
dpc-5458	66	23	psoriasis	psoriasis	NOUN
dpc-5458	66	24	clinical	clinical	ADJ
dpc-5458	66	25	variant	variant	NOUN
dpc-5458	66	26	,	,	PUNCT
dpc-5458	66	27	disease	disease	NOUN
dpc-5458	66	28	duration	duration	NOUN
dpc-5458	66	29	,	,	PUNCT
dpc-5458	66	30	and	and	CCONJ
dpc-5458	66	31	pasi	pasi	NOUN
dpc-5458	66	32	,	,	PUNCT
dpc-5458	66	33	were	be	AUX
dpc-5458	66	34	collected	collect	VERB
dpc-5458	66	35	alongside	alongside	ADP
dpc-5458	66	36	information	information	NOUN
dpc-5458	66	37	about	about	ADP
dpc-5458	66	38	previous	previous	ADJ
dpc-5458	66	39	treatments	treatment	NOUN
dpc-5458	66	40	and	and	CCONJ
dpc-5458	66	41	the	the	DET
dpc-5458	66	42	presence	presence	NOUN
dpc-5458	66	43	of	of	ADP
dpc-5458	66	44	comorbidities	comorbiditie	NOUN
dpc-5458	66	45	.	.	PUNCT
dpc-5458	67	1	data	datum	NOUN
dpc-5458	67	2	collection	collection	NOUN
dpc-5458	67	3	was	be	AUX
dpc-5458	67	4	carried	carry	VERB
dpc-5458	67	5	out	out	ADP
dpc-5458	67	6	while	while	SCONJ
dpc-5458	67	7	ensuring	ensure	VERB
dpc-5458	67	8	the	the	DET
dpc-5458	67	9	anonymity	anonymity	NOUN
dpc-5458	67	10	of	of	ADP
dpc-5458	67	11	the	the	DET
dpc-5458	67	12	participants	participant	NOUN
dpc-5458	67	13	.	.	PUNCT
dpc-5458	68	1	statistycal	statistycal	ADJ
dpc-5458	68	2	analysis	analysis	NOUN
dpc-5458	68	3	the	the	DET
dpc-5458	68	4	imputation	imputation	NOUN
dpc-5458	68	5	of	of	ADP
dpc-5458	68	6	missing	miss	VERB
dpc-5458	68	7	data	datum	NOUN
dpc-5458	68	8	was	be	AUX
dpc-5458	68	9	performed	perform	VERB
dpc-5458	68	10	using	use	VERB
dpc-5458	68	11	the	the	DET
dpc-5458	68	12	last	last	ADJ
dpc-5458	68	13	observation	observation	NOUN
dpc-5458	68	14	carried	carry	VERB
dpc-5458	68	15	forward	forward	ADV
dpc-5458	68	16	(	(	PUNCT
dpc-5458	68	17	locf	locf	PROPN
dpc-5458	68	18	)	)	PUNCT
dpc-5458	68	19	analysis	analysis	NOUN
dpc-5458	68	20	.	.	PUNCT
dpc-5458	69	1	a	a	DET
dpc-5458	69	2	paired	pair	VERB
dpc-5458	69	3	student	student	NOUN
dpc-5458	69	4	t	t	PROPN
dpc-5458	69	5	-	-	PUNCT
dpc-5458	69	6	test	test	NOUN
dpc-5458	69	7	was	be	AUX
dpc-5458	69	8	used	use	VERB
dpc-5458	69	9	to	to	PART
dpc-5458	69	10	compare	compare	VERB
dpc-5458	69	11	baseline	baseline	ADJ
dpc-5458	69	12	values	value	NOUN
dpc-5458	69	13	with	with	ADP
dpc-5458	69	14	those	those	PRON
dpc-5458	69	15	at	at	ADP
dpc-5458	69	16	each	each	DET
dpc-5458	69	17	time	time	NOUN
dpc-5458	69	18	point	point	NOUN
dpc-5458	69	19	(	(	PUNCT
dpc-5458	69	20	weeks	week	NOUN
dpc-5458	69	21	4	4	NUM
dpc-5458	69	22	,	,	PUNCT
dpc-5458	69	23	8	8	NUM
dpc-5458	69	24	,	,	PUNCT
dpc-5458	69	25	12	12	NUM
dpc-5458	69	26	,	,	PUNCT
dpc-5458	69	27	24	24	NUM
dpc-5458	69	28	,	,	PUNCT
dpc-5458	69	29	and	and	CCONJ
dpc-5458	69	30	48	48	NUM
dpc-5458	69	31	)	)	PUNCT
dpc-5458	69	32	.	.	PUNCT
dpc-5458	70	1	data	datum	NOUN
dpc-5458	70	2	are	be	AUX
dpc-5458	70	3	presented	present	VERB
dpc-5458	70	4	as	as	ADP
dpc-5458	70	5	a	a	DET
dpc-5458	70	6	percentage	percentage	NOUN
dpc-5458	70	7	of	of	ADP
dpc-5458	70	8	patients	patient	NOUN
dpc-5458	70	9	who	who	PRON
dpc-5458	70	10	achieved	achieve	VERB
dpc-5458	70	11	pasi	pasi	NOUN
dpc-5458	70	12	50	50	NUM
dpc-5458	70	13	or	or	CCONJ
dpc-5458	70	14	pasi	pasi	NOUN
dpc-5458	70	15	75	75	NUM
dpc-5458	70	16	with	with	ADP
dpc-5458	70	17	a	a	DET
dpc-5458	70	18	pasi	pasi	NOUN
dpc-5458	70	19	score	score	NOUN
dpc-5458	70	20	reduction	reduction	NOUN
dpc-5458	70	21	of	of	ADP
dpc-5458	70	22	50	50	NUM
dpc-5458	70	23	%	%	NOUN
dpc-5458	70	24	and	and	CCONJ
dpc-5458	70	25	75	75	NUM
dpc-5458	70	26	%	%	NOUN
dpc-5458	70	27	(	(	PUNCT
dpc-5458	70	28	pasi	pasi	NOUN
dpc-5458	70	29	50	50	NUM
dpc-5458	70	30	,	,	PUNCT
dpc-5458	70	31	pasi	pasi	NOUN
dpc-5458	70	32	75	75	NUM
dpc-5458	70	33	)	)	PUNCT
dpc-5458	70	34	compared	compare	VERB
dpc-5458	70	35	with	with	ADP
dpc-5458	70	36	baseline	baseline	NOUN
dpc-5458	70	37	.	.	PUNCT
dpc-5458	71	1	to	to	PART
dpc-5458	71	2	estimate	estimate	VERB
dpc-5458	71	3	the	the	DET
dpc-5458	71	4	relationship	relationship	NOUN
dpc-5458	71	5	between	between	ADP
dpc-5458	71	6	variables	variable	NOUN
dpc-5458	71	7	,	,	PUNCT
dpc-5458	71	8	a	a	DET
dpc-5458	71	9	binary	binary	ADJ
dpc-5458	71	10	logistic	logistic	ADJ
dpc-5458	71	11	regression	regression	NOUN
dpc-5458	71	12	analysis	analysis	NOUN
dpc-5458	71	13	(	(	PUNCT
dpc-5458	71	14	binary	binary	ADJ
dpc-5458	71	15	variables	variable	NOUN
dpc-5458	71	16	)	)	PUNCT
dpc-5458	71	17	and	and	CCONJ
dpc-5458	71	18	a	a	DET
dpc-5458	71	19	multiple	multiple	ADJ
dpc-5458	71	20	regression	regression	NOUN
dpc-5458	71	21	analysis	analysis	NOUN
dpc-5458	71	22	(	(	PUNCT
dpc-5458	71	23	continuous	continuous	ADJ
dpc-5458	71	24	variables	variable	NOUN
dpc-5458	71	25	)	)	PUNCT
dpc-5458	71	26	were	be	AUX
dpc-5458	71	27	performed	perform	VERB
dpc-5458	71	28	.	.	PUNCT
dpc-5458	72	1	to	to	PART
dpc-5458	72	2	account	account	VERB
dpc-5458	72	3	for	for	ADP
dpc-5458	72	4	potential	potential	ADJ
dpc-5458	72	5	confounders	confounder	NOUN
dpc-5458	72	6	,	,	PUNCT
dpc-5458	72	7	the	the	DET
dpc-5458	72	8	logistic	logistic	ADJ
dpc-5458	72	9	regression	regression	NOUN
dpc-5458	72	10	model	model	NOUN
dpc-5458	72	11	included	include	VERB
dpc-5458	72	12	the	the	DET
dpc-5458	72	13	following	following	ADJ
dpc-5458	72	14	variables	variable	NOUN
dpc-5458	72	15	as	as	ADP
dpc-5458	72	16	independent	independent	ADJ
dpc-5458	72	17	predictors	predictor	NOUN
dpc-5458	72	18	:	:	PUNCT
dpc-5458	72	19	age	age	NOUN
dpc-5458	72	20	,	,	PUNCT
dpc-5458	72	21	disease	disease	NOUN
dpc-5458	72	22	duration	duration	NOUN
dpc-5458	72	23	,	,	PUNCT
dpc-5458	72	24	bmi	bmi	X
dpc-5458	72	25	≥	≥	NUM
dpc-5458	72	26	30	30	NUM
dpc-5458	72	27	,	,	PUNCT
dpc-5458	72	28	maximum	maximum	ADJ
dpc-5458	72	29	dosage	dosage	NOUN
dpc-5458	72	30	,	,	PUNCT
dpc-5458	72	31	and	and	CCONJ
dpc-5458	72	32	number	number	NOUN
dpc-5458	72	33	of	of	ADP
dpc-5458	72	34	comorbidities	comorbiditie	NOUN
dpc-5458	72	35	.	.	PUNCT
dpc-5458	73	1	statistical	statistical	ADJ
dpc-5458	73	2	analyses	analysis	NOUN
dpc-5458	73	3	were	be	AUX
dpc-5458	73	4	performed	perform	VERB
dpc-5458	73	5	using	use	VERB
dpc-5458	73	6	medcalc	medcalc	ADJ
dpc-5458	73	7	®	®	NOUN
dpc-5458	73	8	statistical	statistical	ADJ
dpc-5458	73	9	software	software	NOUN
dpc-5458	73	10	(	(	PUNCT
dpc-5458	73	11	medcalc	medcalc	PROPN
dpc-5458	73	12	software	software	PROPN
dpc-5458	73	13	ltd	ltd	PROPN
dpc-5458	73	14	,	,	PUNCT
dpc-5458	73	15	ostend	ostend	PROPN
dpc-5458	73	16	,	,	PUNCT
dpc-5458	73	17	belgium	belgium	NOUN
dpc-5458	73	18	;	;	PUNCT
dpc-5458	73	19	https://www.medcalc.org	https://www.medcalc.org	NUM
dpc-5458	73	20	;	;	PUNCT
dpc-5458	73	21	2025	2025	NUM
dpc-5458	73	22	)	)	PUNCT
dpc-5458	73	23	.	.	PUNCT
dpc-5458	74	1	results	result	VERB
dpc-5458	74	2	a	a	DET
dpc-5458	74	3	total	total	NOUN
dpc-5458	74	4	of	of	ADP
dpc-5458	74	5	148	148	NUM
dpc-5458	74	6	patients	patient	NOUN
dpc-5458	74	7	were	be	AUX
dpc-5458	74	8	enrolled	enrol	VERB
dpc-5458	74	9	in	in	ADP
dpc-5458	74	10	the	the	DET
dpc-5458	74	11	study	study	NOUN
dpc-5458	74	12	,	,	PUNCT
dpc-5458	74	13	of	of	ADP
dpc-5458	74	14	whom	whom	PRON
dpc-5458	74	15	94	94	NUM
dpc-5458	74	16	(	(	PUNCT
dpc-5458	74	17	63.5	63.5	NUM
dpc-5458	74	18	%	%	NOUN
dpc-5458	74	19	)	)	PUNCT
dpc-5458	74	20	were	be	AUX
dpc-5458	74	21	male	male	ADJ
dpc-5458	74	22	.	.	PUNCT
dpc-5458	75	1	the	the	DET
dpc-5458	75	2	mean	mean	ADJ
dpc-5458	75	3	pasi	pasi	NOUN
dpc-5458	75	4	was	be	AUX
dpc-5458	75	5	8.9	8.9	NUM
dpc-5458	75	6	(	(	PUNCT
dpc-5458	75	7	±4.2	±4.2	PROPN
dpc-5458	75	8	)	)	PUNCT
dpc-5458	75	9	.	.	PUNCT
dpc-5458	76	1	the	the	DET
dpc-5458	76	2	average	average	ADJ
dpc-5458	76	3	age	age	NOUN
dpc-5458	76	4	was	be	AUX
dpc-5458	76	5	53.8	53.8	NUM
dpc-5458	76	6	(	(	PUNCT
dpc-5458	76	7	range	range	NOUN
dpc-5458	76	8	19–88	19–88	NUM
dpc-5458	76	9	)	)	PUNCT
dpc-5458	76	10	,	,	PUNCT
dpc-5458	76	11	and	and	CCONJ
dpc-5458	76	12	18	18	NUM
dpc-5458	76	13	(	(	PUNCT
dpc-5458	76	14	12.2	12.2	NUM
dpc-5458	76	15	%	%	NOUN
dpc-5458	76	16	)	)	PUNCT
dpc-5458	76	17	patients	patient	NOUN
dpc-5458	76	18	had	have	VERB
dpc-5458	76	19	a	a	DET
dpc-5458	76	20	bmi	bmi	NOUN
dpc-5458	76	21	≥30	≥30	PROPN
dpc-5458	76	22	(	(	PUNCT
dpc-5458	76	23	table	table	NOUN
dpc-5458	76	24	1	1	NUM
dpc-5458	76	25	)	)	PUNCT
dpc-5458	76	26	.	.	PUNCT
dpc-5458	77	1	the	the	DET
dpc-5458	77	2	most	most	ADV
dpc-5458	77	3	prevalent	prevalent	ADJ
dpc-5458	77	4	variant	variant	NOUN
dpc-5458	77	5	of	of	ADP
dpc-5458	77	6	psoriasis	psoriasis	NOUN
dpc-5458	77	7	was	be	AUX
dpc-5458	77	8	the	the	DET
dpc-5458	77	9	plaque	plaque	NOUN
dpc-5458	77	10	type	type	NOUN
dpc-5458	77	11	(	(	PUNCT
dpc-5458	77	12	141	141	NUM
dpc-5458	77	13	patients	patient	NOUN
dpc-5458	77	14	,	,	PUNCT
dpc-5458	77	15	95.3	95.3	NUM
dpc-5458	77	16	%	%	NOUN
dpc-5458	77	17	)	)	PUNCT
dpc-5458	77	18	,	,	PUNCT
dpc-5458	77	19	followed	follow	VERB
dpc-5458	77	20	by	by	ADP
dpc-5458	77	21	palmoplantar	palmoplantar	NOUN
dpc-5458	77	22	psoriasis	psoriasis	NOUN
dpc-5458	77	23	(	(	PUNCT
dpc-5458	77	24	17	17	NUM
dpc-5458	77	25	patients	patient	NOUN
dpc-5458	77	26	,	,	PUNCT
dpc-5458	77	27	11.5	11.5	NUM
dpc-5458	77	28	%	%	NOUN
dpc-5458	77	29	)	)	PUNCT
dpc-5458	77	30	,	,	PUNCT
dpc-5458	77	31	inverse	inverse	ADJ
dpc-5458	77	32	psoriasis	psoriasis	NOUN
dpc-5458	77	33	(	(	PUNCT
dpc-5458	77	34	five	five	NUM
dpc-5458	77	35	patients	patient	NOUN
dpc-5458	77	36	,	,	PUNCT
dpc-5458	77	37	3.4	3.4	NUM
dpc-5458	77	38	%	%	NOUN
dpc-5458	77	39	)	)	PUNCT
dpc-5458	77	40	,	,	PUNCT
dpc-5458	77	41	and	and	CCONJ
dpc-5458	77	42	psoriatic	psoriatic	ADJ
dpc-5458	77	43	arthritis	arthritis	NOUN
dpc-5458	77	44	(	(	PUNCT
dpc-5458	77	45	two	two	NUM
dpc-5458	77	46	patients	patient	NOUN
dpc-5458	77	47	,	,	PUNCT
dpc-5458	77	48	1.4	1.4	NUM
dpc-5458	77	49	%	%	NOUN
dpc-5458	77	50	)	)	PUNCT
dpc-5458	77	51	.	.	PUNCT
dpc-5458	78	1	most	most	ADJ
dpc-5458	78	2	of	of	ADP
dpc-5458	78	3	the	the	DET
dpc-5458	78	4	population	population	NOUN
dpc-5458	78	5	had	have	VERB
dpc-5458	78	6	at	at	ADV
dpc-5458	78	7	least	least	ADV
dpc-5458	78	8	one	one	NUM
dpc-5458	78	9	comorbidity	comorbidity	NOUN
dpc-5458	78	10	(	(	PUNCT
dpc-5458	78	11	52.7	52.7	NUM
dpc-5458	78	12	%	%	NOUN
dpc-5458	78	13	)	)	PUNCT
dpc-5458	78	14	.	.	PUNCT
dpc-5458	79	1	notably	notably	ADV
dpc-5458	79	2	,	,	PUNCT
dpc-5458	79	3	some	some	DET
dpc-5458	79	4	patients	patient	NOUN
dpc-5458	79	5	displayed	display	VERB
dpc-5458	79	6	relevant	relevant	ADJ
dpc-5458	79	7	comorbidities	comorbiditie	NOUN
dpc-5458	79	8	,	,	PUNCT
dpc-5458	79	9	including	include	VERB
dpc-5458	79	10	various	various	ADJ
dpc-5458	79	11	types	type	NOUN
dpc-5458	79	12	of	of	ADP
dpc-5458	79	13	anamnestic	anamnestic	ADJ
dpc-5458	79	14	cancer	cancer	NOUN
dpc-5458	79	15	,	,	PUNCT
dpc-5458	79	16	hepatitis	hepatitis	PROPN
dpc-5458	79	17	b	b	PROPN
dpc-5458	79	18	virus	virus	NOUN
dpc-5458	79	19	or	or	CCONJ
dpc-5458	79	20	hepatitis	hepatitis	PROPN
dpc-5458	79	21	c	c	PROPN
dpc-5458	79	22	virus	virus	NOUN
dpc-5458	79	23	infections	infection	NOUN
dpc-5458	79	24	,	,	PUNCT
dpc-5458	79	25	tuberculosis	tuberculosis	NOUN
dpc-5458	79	26	(	(	PUNCT
dpc-5458	79	27	tb	tb	NOUN
dpc-5458	79	28	)	)	PUNCT
dpc-5458	79	29	,	,	PUNCT
dpc-5458	79	30	or	or	CCONJ
dpc-5458	79	31	multiple	multiple	ADJ
dpc-5458	79	32	sclerosis	sclerosis	NOUN
dpc-5458	79	33	.	.	PUNCT
dpc-5458	80	1	among	among	ADP
dpc-5458	80	2	the	the	DET
dpc-5458	80	3	study	study	NOUN
dpc-5458	80	4	group	group	NOUN
dpc-5458	80	5	,	,	PUNCT
dpc-5458	80	6	95	95	NUM
dpc-5458	80	7	patients	patient	NOUN
dpc-5458	80	8	(	(	PUNCT
dpc-5458	80	9	64.2	64.2	NUM
dpc-5458	80	10	%	%	NOUN
dpc-5458	80	11	)	)	PUNCT
dpc-5458	80	12	had	have	AUX
dpc-5458	80	13	not	not	PART
dpc-5458	80	14	been	be	AUX
dpc-5458	80	15	previously	previously	ADV
dpc-5458	80	16	treated	treat	VERB
dpc-5458	80	17	for	for	ADP
dpc-5458	80	18	psoriasis	psoriasis	NOUN
dpc-5458	80	19	.	.	PUNCT
dpc-5458	81	1	in	in	ADP
dpc-5458	81	2	contrast	contrast	NOUN
dpc-5458	81	3	,	,	PUNCT
dpc-5458	81	4	33.8	33.8	NUM
dpc-5458	81	5	%	%	NOUN
dpc-5458	81	6	had	have	AUX
dpc-5458	81	7	received	receive	VERB
dpc-5458	81	8	conventional	conventional	ADJ
dpc-5458	81	9	therapies	therapy	NOUN
dpc-5458	81	10	,	,	PUNCT
dpc-5458	81	11	including	include	VERB
dpc-5458	81	12	acitretin	acitretin	NOUN
dpc-5458	81	13	(	(	PUNCT
dpc-5458	81	14	16	16	NUM
dpc-5458	81	15	patients	patient	NOUN
dpc-5458	81	16	,	,	PUNCT
dpc-5458	81	17	10.8	10.8	NUM
dpc-5458	81	18	%	%	NOUN
dpc-5458	81	19	)	)	PUNCT
dpc-5458	81	20	,	,	PUNCT
dpc-5458	81	21	cyclosporin	cyclosporin	NOUN
dpc-5458	81	22	(	(	PUNCT
dpc-5458	81	23	31	31	NUM
dpc-5458	81	24	patients	patient	NOUN
dpc-5458	81	25	,	,	PUNCT
dpc-5458	81	26	20.9	20.9	NUM
dpc-5458	81	27	%	%	NOUN
dpc-5458	81	28	)	)	PUNCT
dpc-5458	81	29	,	,	PUNCT
dpc-5458	81	30	or	or	CCONJ
dpc-5458	81	31	mtx	mtx	NOUN
dpc-5458	81	32	(	(	PUNCT
dpc-5458	81	33	18	18	NUM
dpc-5458	81	34	patients	patient	NOUN
dpc-5458	81	35	,	,	PUNCT
dpc-5458	81	36	12.2	12.2	NUM
dpc-5458	81	37	%	%	NOUN
dpc-5458	81	38	)	)	PUNCT
dpc-5458	81	39	.	.	PUNCT
dpc-5458	82	1	a	a	DET
dpc-5458	82	2	smaller	small	ADJ
dpc-5458	82	3	proportion	proportion	NOUN
dpc-5458	82	4	(	(	PUNCT
dpc-5458	82	5	4.7	4.7	NUM
dpc-5458	82	6	%	%	NOUN
dpc-5458	82	7	)	)	PUNCT
dpc-5458	82	8	had	have	AUX
dpc-5458	82	9	been	be	AUX
dpc-5458	82	10	treated	treat	VERB
dpc-5458	82	11	with	with	ADP
dpc-5458	82	12	biological	biological	ADJ
dpc-5458	82	13	systemic	systemic	ADJ
dpc-5458	82	14	4	4	NUM
dpc-5458	82	15	original	original	ADJ
dpc-5458	82	16	article	article	NOUN
dpc-5458	82	17	|	|	ADV
dpc-5458	82	18	dermatol	dermatol	ADJ
dpc-5458	82	19	pract	pract	NOUN
dpc-5458	82	20	concept	concept	NOUN
dpc-5458	82	21	.	.	PUNCT
dpc-5458	83	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	83	2	table	table	NOUN
dpc-5458	83	3	1	1	NUM
dpc-5458	83	4	.	.	PUNCT
dpc-5458	83	5	patient	patient	ADJ
dpc-5458	83	6	baseline	baseline	PROPN
dpc-5458	83	7	characteristics	characteristic	NOUN
dpc-5458	83	8	.	.	PUNCT
dpc-5458	84	1	characteristics	characteristic	NOUN
dpc-5458	84	2	n=148	n=148	NOUN
dpc-5458	84	3	sex	sex	NOUN
dpc-5458	84	4	(	(	PUNCT
dpc-5458	84	5	male	male	NOUN
dpc-5458	84	6	)	)	PUNCT
dpc-5458	84	7	94	94	NUM
dpc-5458	84	8	(	(	PUNCT
dpc-5458	84	9	63.5	63.5	NUM
dpc-5458	84	10	)	)	PUNCT
dpc-5458	84	11	age	age	NOUN
dpc-5458	84	12	(	(	PUNCT
dpc-5458	84	13	years	year	NOUN
dpc-5458	84	14	)	)	PUNCT
dpc-5458	84	15	53.8	53.8	NUM
dpc-5458	84	16	(	(	PUNCT
dpc-5458	84	17	±16.6	±16.6	PROPN
dpc-5458	84	18	,	,	PUNCT
dpc-5458	84	19	19–88	19–88	NUM
dpc-5458	84	20	)	)	PUNCT
dpc-5458	84	21	weight	weight	NOUN
dpc-5458	84	22	(	(	PUNCT
dpc-5458	84	23	kg	kg	NOUN
dpc-5458	84	24	)	)	PUNCT
dpc-5458	84	25	75.4	75.4	NUM
dpc-5458	84	26	(	(	PUNCT
dpc-5458	84	27	±13.0	±13.0	PROPN
dpc-5458	84	28	,	,	PUNCT
dpc-5458	84	29	45.0–123.0	45.0–123.0	NUM
dpc-5458	84	30	)	)	PUNCT
dpc-5458	84	31	bmi	bmi	NOUN
dpc-5458	84	32	(	(	PUNCT
dpc-5458	84	33	kg	kg	NOUN
dpc-5458	84	34	/	/	SYM
dpc-5458	84	35	m2	m2	PROPN
dpc-5458	84	36	)	)	PUNCT
dpc-5458	84	37	26.6	26.6	NUM
dpc-5458	84	38	(	(	PUNCT
dpc-5458	84	39	±3.8	±3.8	PROPN
dpc-5458	84	40	,	,	PUNCT
dpc-5458	84	41	17.6–42.6	17.6–42.6	NUM
dpc-5458	84	42	)	)	PUNCT
dpc-5458	84	43	bmi	bmi	NOUN
dpc-5458	85	1	≥30	≥30	PROPN
dpc-5458	85	2	18	18	NUM
dpc-5458	85	3	(	(	PUNCT
dpc-5458	85	4	22.2	22.2	NUM
dpc-5458	85	5	)	)	PUNCT
dpc-5458	85	6	psoriasis	psoriasis	NOUN
dpc-5458	85	7	clinical	clinical	ADJ
dpc-5458	85	8	variants	variant	NOUN
dpc-5458	85	9	•	•	ADP
dpc-5458	85	10	plaque	plaque	NOUN
dpc-5458	85	11	type	type	NOUN
dpc-5458	85	12	•	•	NOUN
dpc-5458	85	13	inverse	inverse	NOUN
dpc-5458	85	14	psoriasis	psoriasis	NOUN
dpc-5458	85	15	•	•	NOUN
dpc-5458	85	16	palmoplantar	palmoplantar	NOUN
dpc-5458	85	17	psoriasis	psoriasis	NOUN
dpc-5458	85	18	•	•	NOUN
dpc-5458	86	1	psoriatic	psoriatic	ADJ
dpc-5458	86	2	arthritis	arthritis	NOUN
dpc-5458	86	3	141	141	NUM
dpc-5458	86	4	(	(	PUNCT
dpc-5458	86	5	95.3	95.3	NUM
dpc-5458	86	6	)	)	SYM
dpc-5458	86	7	5	5	NUM
dpc-5458	86	8	(	(	PUNCT
dpc-5458	86	9	3.4	3.4	NUM
dpc-5458	86	10	)	)	PUNCT
dpc-5458	86	11	17	17	NUM
dpc-5458	86	12	(	(	PUNCT
dpc-5458	86	13	11.5	11.5	NUM
dpc-5458	86	14	)	)	PUNCT
dpc-5458	86	15	2	2	NUM
dpc-5458	86	16	(	(	PUNCT
dpc-5458	86	17	1.4	1.4	NUM
dpc-5458	86	18	)	)	PUNCT
dpc-5458	86	19	disease	disease	NOUN
dpc-5458	86	20	duration	duration	NOUN
dpc-5458	86	21	(	(	PUNCT
dpc-5458	86	22	years	year	NOUN
dpc-5458	86	23	)	)	PUNCT
dpc-5458	86	24	16.9	16.9	NUM
dpc-5458	86	25	(	(	PUNCT
dpc-5458	86	26	±14.3	±14.3	X
dpc-5458	86	27	,	,	PUNCT
dpc-5458	86	28	1–65	1–65	NUM
dpc-5458	86	29	)	)	PUNCT
dpc-5458	86	30	mean	mean	PROPN
dpc-5458	86	31	pasi	pasi	NOUN
dpc-5458	86	32	8.9	8.9	NUM
dpc-5458	86	33	(	(	PUNCT
dpc-5458	86	34	±4.2	±4.2	PROPN
dpc-5458	86	35	)	)	PUNCT
dpc-5458	86	36	comorbidities	comorbiditie	NOUN
dpc-5458	86	37	•	•	ADV
dpc-5458	86	38	none	none	NOUN
dpc-5458	86	39	•	•	NOUN
dpc-5458	86	40	1	1	NUM
dpc-5458	86	41	•	•	NUM
dpc-5458	86	42	2	2	NUM
dpc-5458	86	43	•	•	NUM
dpc-5458	86	44	3	3	NUM
dpc-5458	86	45	•	•	NOUN
dpc-5458	86	46	>	>	SYM
dpc-5458	86	47	3	3	NUM
dpc-5458	86	48	70	70	NUM
dpc-5458	86	49	(	(	PUNCT
dpc-5458	86	50	47.3	47.3	NUM
dpc-5458	86	51	)	)	PUNCT
dpc-5458	86	52	31	31	NUM
dpc-5458	86	53	(	(	PUNCT
dpc-5458	86	54	20.9	20.9	NUM
dpc-5458	86	55	)	)	SYM
dpc-5458	86	56	26	26	NUM
dpc-5458	86	57	(	(	PUNCT
dpc-5458	86	58	17.6	17.6	NUM
dpc-5458	86	59	)	)	PUNCT
dpc-5458	86	60	12	12	NUM
dpc-5458	86	61	(	(	PUNCT
dpc-5458	86	62	8.1	8.1	NUM
dpc-5458	86	63	)	)	PUNCT
dpc-5458	86	64	10	10	NUM
dpc-5458	86	65	(	(	PUNCT
dpc-5458	86	66	6.8	6.8	NUM
dpc-5458	86	67	)	)	PUNCT
dpc-5458	86	68	comorbidities	comorbiditie	NOUN
dpc-5458	86	69	of	of	ADP
dpc-5458	86	70	interest	interest	NOUN
dpc-5458	86	71	neoplasms	neoplasm	NOUN
dpc-5458	86	72	•	•	ADP
dpc-5458	86	73	malignant	malignant	ADJ
dpc-5458	86	74	melanoma	melanoma	NOUN
dpc-5458	86	75	•	•	PRON
dpc-5458	86	76	non	non	ADJ
dpc-5458	86	77	-	-	ADJ
dpc-5458	86	78	melanoma	melanoma	ADJ
dpc-5458	86	79	skin	skin	NOUN
dpc-5458	86	80	cancer	cancer	NOUN
dpc-5458	86	81	•	•	NOUN
dpc-5458	86	82	prostate	prostate	NOUN
dpc-5458	86	83	cancer	cancer	NOUN
dpc-5458	86	84	•	•	NOUN
dpc-5458	86	85	colorectal	colorectal	ADJ
dpc-5458	86	86	cancer	cancer	NOUN
dpc-5458	86	87	•	•	NOUN
dpc-5458	86	88	thyroid	thyroid	NOUN
dpc-5458	86	89	cancer	cancer	NOUN
dpc-5458	86	90	•	•	NUM
dpc-5458	86	91	parathyroid	parathyroid	ADJ
dpc-5458	86	92	cancer	cancer	NOUN
dpc-5458	86	93	9	9	NUM
dpc-5458	86	94	(	(	PUNCT
dpc-5458	86	95	6.1	6.1	NUM
dpc-5458	86	96	%	%	NOUN
dpc-5458	86	97	)	)	PUNCT
dpc-5458	86	98	3	3	NUM
dpc-5458	86	99	(	(	PUNCT
dpc-5458	86	100	2.0	2.0	NUM
dpc-5458	86	101	%	%	NOUN
dpc-5458	86	102	)	)	PUNCT
dpc-5458	86	103	2	2	NUM
dpc-5458	86	104	(	(	PUNCT
dpc-5458	86	105	1.4	1.4	NUM
dpc-5458	86	106	%	%	NOUN
dpc-5458	86	107	)	)	PUNCT
dpc-5458	86	108	1	1	NUM
dpc-5458	86	109	(	(	PUNCT
dpc-5458	86	110	0.7	0.7	NUM
dpc-5458	86	111	%	%	NOUN
dpc-5458	86	112	)	)	PUNCT
dpc-5458	86	113	1	1	NUM
dpc-5458	86	114	(	(	PUNCT
dpc-5458	86	115	0.7	0.7	NUM
dpc-5458	86	116	%	%	NOUN
dpc-5458	86	117	)	)	PUNCT
dpc-5458	86	118	1	1	NUM
dpc-5458	86	119	(	(	PUNCT
dpc-5458	86	120	0.7	0.7	NUM
dpc-5458	86	121	%	%	NOUN
dpc-5458	86	122	)	)	PUNCT
dpc-5458	86	123	1	1	NUM
dpc-5458	86	124	(	(	PUNCT
dpc-5458	86	125	0.7	0.7	NUM
dpc-5458	86	126	%	%	NOUN
dpc-5458	86	127	)	)	PUNCT
dpc-5458	86	128	infections	infection	NOUN
dpc-5458	86	129	or	or	CCONJ
dpc-5458	86	130	other	other	ADJ
dpc-5458	86	131	relevant	relevant	ADJ
dpc-5458	86	132	comorbidities	comorbiditie	NOUN
dpc-5458	86	133	•	•	ADP
dpc-5458	86	134	hbv	hbv	NOUN
dpc-5458	86	135	•	•	ADP
dpc-5458	86	136	hcv	hcv	PROPN
dpc-5458	86	137	•	•	NOUN
dpc-5458	86	138	igra	igra	PROPN
dpc-5458	86	139	tb	tb	ADP
dpc-5458	86	140	positive	positive	ADJ
dpc-5458	86	141	•	•	ADJ
dpc-5458	86	142	multiple	multiple	ADJ
dpc-5458	86	143	sclerosis	sclerosis	NOUN
dpc-5458	86	144	6	6	NUM
dpc-5458	86	145	(	(	PUNCT
dpc-5458	86	146	4.1	4.1	NUM
dpc-5458	86	147	%	%	NOUN
dpc-5458	86	148	)	)	PUNCT
dpc-5458	86	149	3	3	NUM
dpc-5458	86	150	(	(	PUNCT
dpc-5458	86	151	2.0	2.0	NUM
dpc-5458	86	152	%	%	NOUN
dpc-5458	86	153	)	)	PUNCT
dpc-5458	86	154	5	5	NUM
dpc-5458	86	155	(	(	PUNCT
dpc-5458	86	156	3.4	3.4	NUM
dpc-5458	86	157	%	%	NOUN
dpc-5458	86	158	)	)	PUNCT
dpc-5458	86	159	2	2	NUM
dpc-5458	86	160	(	(	PUNCT
dpc-5458	86	161	1.4	1.4	NUM
dpc-5458	86	162	%	%	NOUN
dpc-5458	86	163	)	)	PUNCT
dpc-5458	86	164	previous	previous	ADJ
dpc-5458	86	165	therapy	therapy	NOUN
dpc-5458	86	166	none	none	NOUN
dpc-5458	86	167	95	95	NUM
dpc-5458	86	168	(	(	PUNCT
dpc-5458	86	169	64.2	64.2	NUM
dpc-5458	86	170	%	%	NOUN
dpc-5458	86	171	)	)	PUNCT
dpc-5458	86	172	conventional	conventional	ADJ
dpc-5458	86	173	systemic	systemic	ADJ
dpc-5458	86	174	therapies	therapy	NOUN
dpc-5458	86	175	•	•	ADV
dpc-5458	86	176	acitretin	acitretin	VERB
dpc-5458	86	177	•	•	NUM
dpc-5458	86	178	cyclosporin	cyclosporin	NOUN
dpc-5458	86	179	•	•	NUM
dpc-5458	86	180	methotrexate	methotrexate	VERB
dpc-5458	86	181	50	50	NUM
dpc-5458	86	182	(	(	PUNCT
dpc-5458	86	183	33.8	33.8	NUM
dpc-5458	86	184	%	%	NOUN
dpc-5458	86	185	)	)	PUNCT
dpc-5458	86	186	16	16	NUM
dpc-5458	86	187	(	(	PUNCT
dpc-5458	86	188	10.8	10.8	NUM
dpc-5458	86	189	%	%	NOUN
dpc-5458	86	190	)	)	PUNCT
dpc-5458	86	191	31	31	NUM
dpc-5458	86	192	(	(	PUNCT
dpc-5458	86	193	20.9	20.9	NUM
dpc-5458	86	194	%	%	NOUN
dpc-5458	86	195	)	)	PUNCT
dpc-5458	86	196	18	18	NUM
dpc-5458	86	197	(	(	PUNCT
dpc-5458	86	198	12.2	12.2	NUM
dpc-5458	86	199	%	%	NOUN
dpc-5458	86	200	)	)	PUNCT
dpc-5458	86	201	biological	biological	ADJ
dpc-5458	86	202	systemic	systemic	ADJ
dpc-5458	86	203	therapies	therapy	NOUN
dpc-5458	86	204	•	•	NOUN
dpc-5458	86	205	tnf	tnf	PROPN
dpc-5458	86	206	inhibitors	inhibitor	NOUN
dpc-5458	86	207	•	•	PRON
dpc-5458	86	208	ustekinumab	ustekinumab	NOUN
dpc-5458	86	209	•	•	ADP
dpc-5458	86	210	il-23	il-23	NOUN
dpc-5458	86	211	inhibitors	inhibitor	NOUN
dpc-5458	86	212	7	7	NUM
dpc-5458	86	213	(	(	PUNCT
dpc-5458	86	214	4.7	4.7	NUM
dpc-5458	86	215	%	%	NOUN
dpc-5458	86	216	)	)	PUNCT
dpc-5458	86	217	5	5	NUM
dpc-5458	86	218	(	(	PUNCT
dpc-5458	86	219	3.4	3.4	NUM
dpc-5458	86	220	%	%	NOUN
dpc-5458	86	221	)	)	PUNCT
dpc-5458	86	222	1	1	NUM
dpc-5458	86	223	(	(	PUNCT
dpc-5458	86	224	0.7	0.7	NUM
dpc-5458	86	225	%	%	NOUN
dpc-5458	86	226	)	)	PUNCT
dpc-5458	86	227	1	1	NUM
dpc-5458	86	228	(	(	PUNCT
dpc-5458	86	229	0.7	0.7	NUM
dpc-5458	86	230	%	%	NOUN
dpc-5458	86	231	)	)	PUNCT
dpc-5458	86	232	small	small	ADJ
dpc-5458	86	233	molecule	molecule	NOUN
dpc-5458	86	234	(	(	PUNCT
dpc-5458	86	235	apremilast	apremilast	ADJ
dpc-5458	86	236	)	)	PUNCT
dpc-5458	86	237	7	7	NUM
dpc-5458	86	238	(	(	PUNCT
dpc-5458	86	239	4.7	4.7	NUM
dpc-5458	86	240	%	%	NOUN
dpc-5458	86	241	)	)	PUNCT
dpc-5458	86	242	data	datum	NOUN
dpc-5458	86	243	are	be	AUX
dpc-5458	86	244	presented	present	VERB
dpc-5458	86	245	as	as	ADP
dpc-5458	86	246	mean	mean	ADJ
dpc-5458	86	247	(	(	PUNCT
dpc-5458	86	248	±sd	±sd	NOUN
dpc-5458	86	249	,	,	PUNCT
dpc-5458	86	250	range	range	NOUN
dpc-5458	86	251	)	)	PUNCT
dpc-5458	86	252	or	or	CCONJ
dpc-5458	86	253	n	n	PRON
dpc-5458	86	254	(	(	PUNCT
dpc-5458	86	255	%	%	NOUN
dpc-5458	86	256	)	)	PUNCT
dpc-5458	86	257	.	.	PUNCT
dpc-5458	87	1	abbreviations	abbreviation	NOUN
dpc-5458	87	2	:	:	PUNCT
dpc-5458	87	3	bmi	bmi	PROPN
dpc-5458	87	4	:	:	PUNCT
dpc-5458	87	5	body	body	NOUN
dpc-5458	87	6	mass	mass	PROPN
dpc-5458	87	7	index	index	NOUN
dpc-5458	87	8	;	;	PUNCT
dpc-5458	87	9	hbv	hbv	NOUN
dpc-5458	87	10	:	:	PUNCT
dpc-5458	87	11	hepatitis	hepatitis	PROPN
dpc-5458	87	12	b	b	PROPN
dpc-5458	87	13	virus	virus	NOUN
dpc-5458	87	14	;	;	PUNCT
dpc-5458	87	15	hcv	hcv	NOUN
dpc-5458	87	16	:	:	PUNCT
dpc-5458	87	17	hepatitis	hepatitis	PROPN
dpc-5458	87	18	c	c	PROPN
dpc-5458	87	19	virus	virus	NOUN
dpc-5458	87	20	;	;	PUNCT
dpc-5458	87	21	pasi	pasi	NOUN
dpc-5458	87	22	:	:	PUNCT
dpc-5458	87	23	psoriasis	psoriasis	NOUN
dpc-5458	87	24	area	area	NOUN
dpc-5458	87	25	severity	severity	NOUN
dpc-5458	87	26	index	index	NOUN
dpc-5458	87	27	;	;	PUNCT
dpc-5458	87	28	igra	igra	PROPN
dpc-5458	87	29	tb	tb	NOUN
dpc-5458	87	30	:	:	PUNCT
dpc-5458	87	31	interferon	interferon	ADJ
dpc-5458	87	32	gamma	gamma	NOUN
dpc-5458	87	33	release	release	VERB
dpc-5458	87	34	assay	assay	NOUN
dpc-5458	87	35	test	test	NOUN
dpc-5458	87	36	for	for	ADP
dpc-5458	87	37	tuberculosis	tuberculosis	NOUN
dpc-5458	87	38	;	;	PUNCT
dpc-5458	87	39	tnf	tnf	PROPN
dpc-5458	87	40	:	:	PUNCT
dpc-5458	87	41	tumor	tumor	NOUN
dpc-5458	87	42	necrosis	necrosis	NOUN
dpc-5458	87	43	factor	factor	NOUN
dpc-5458	87	44	.	.	PUNCT
dpc-5458	88	1	therapies	therapy	NOUN
dpc-5458	88	2	:	:	PUNCT
dpc-5458	88	3	tnf	tnf	NUM
dpc-5458	88	4	inhibitors	inhibitor	NOUN
dpc-5458	88	5	in	in	ADP
dpc-5458	88	6	3.4	3.4	NUM
dpc-5458	88	7	%	%	NOUN
dpc-5458	88	8	(	(	PUNCT
dpc-5458	88	9	five	five	NUM
dpc-5458	88	10	patients	patient	NOUN
dpc-5458	88	11	)	)	PUNCT
dpc-5458	88	12	,	,	PUNCT
dpc-5458	88	13	ustekinumab	ustekinumab	NOUN
dpc-5458	88	14	in	in	ADP
dpc-5458	88	15	0.7	0.7	NUM
dpc-5458	88	16	%	%	NOUN
dpc-5458	88	17	(	(	PUNCT
dpc-5458	88	18	one	one	NUM
dpc-5458	88	19	patient	patient	NOUN
dpc-5458	88	20	)	)	PUNCT
dpc-5458	88	21	,	,	PUNCT
dpc-5458	88	22	and	and	CCONJ
dpc-5458	88	23	il-23	il-23	VERB
dpc-5458	88	24	inhibitors	inhibitor	NOUN
dpc-5458	88	25	in	in	ADP
dpc-5458	88	26	0.7	0.7	NUM
dpc-5458	88	27	%	%	NOUN
dpc-5458	88	28	(	(	PUNCT
dpc-5458	88	29	one	one	NUM
dpc-5458	88	30	patient	patient	NOUN
dpc-5458	88	31	)	)	PUNCT
dpc-5458	88	32	.	.	PUNCT
dpc-5458	89	1	additionally	additionally	ADV
dpc-5458	89	2	,	,	PUNCT
dpc-5458	89	3	4.7	4.7	NUM
dpc-5458	89	4	%	%	NOUN
dpc-5458	89	5	(	(	PUNCT
dpc-5458	89	6	seven	seven	NUM
dpc-5458	89	7	patients	patient	NOUN
dpc-5458	89	8	)	)	PUNCT
dpc-5458	89	9	had	have	AUX
dpc-5458	89	10	been	be	AUX
dpc-5458	89	11	treated	treat	VERB
dpc-5458	89	12	with	with	ADP
dpc-5458	89	13	apremilast	apremilast	ADJ
dpc-5458	89	14	(	(	PUNCT
dpc-5458	89	15	table	table	NOUN
dpc-5458	89	16	1	1	NUM
dpc-5458	89	17	)	)	PUNCT
dpc-5458	89	18	.	.	PUNCT
dpc-5458	90	1	dmf	dmf	PROPN
dpc-5458	90	2	was	be	AUX
dpc-5458	90	3	effective	effective	ADJ
dpc-5458	90	4	in	in	ADP
dpc-5458	90	5	reducing	reduce	VERB
dpc-5458	90	6	the	the	DET
dpc-5458	90	7	mean	mean	ADJ
dpc-5458	90	8	pasi	pasi	NOUN
dpc-5458	90	9	from	from	ADP
dpc-5458	90	10	baseline	baseline	NOUN
dpc-5458	90	11	at	at	ADP
dpc-5458	90	12	week	week	NOUN
dpc-5458	90	13	4	4	NUM
dpc-5458	90	14	,	,	PUNCT
dpc-5458	90	15	with	with	ADP
dpc-5458	90	16	efficacy	efficacy	NOUN
dpc-5458	90	17	increasing	increase	VERB
dpc-5458	90	18	through	through	ADP
dpc-5458	90	19	week	week	NOUN
dpc-5458	90	20	48	48	NUM
dpc-5458	90	21	(	(	PUNCT
dpc-5458	90	22	10.0	10.0	NUM
dpc-5458	90	23	vs.	vs.	ADP
dpc-5458	90	24	1.8	1.8	NUM
dpc-5458	90	25	,	,	PUNCT
dpc-5458	90	26	p<0.001	p<0.001	ADJ
dpc-5458	90	27	,	,	PUNCT
dpc-5458	90	28	table	table	NOUN
dpc-5458	90	29	2	2	NUM
dpc-5458	90	30	)	)	PUNCT
dpc-5458	90	31	.	.	PUNCT
dpc-5458	91	1	the	the	DET
dpc-5458	91	2	locf	locf	PROPN
dpc-5458	91	3	analysis	analysis	NOUN
dpc-5458	91	4	also	also	ADV
dpc-5458	91	5	showed	show	VERB
dpc-5458	91	6	a	a	DET
dpc-5458	91	7	significant	significant	ADJ
dpc-5458	91	8	effect	effect	NOUN
dpc-5458	91	9	of	of	ADP
dpc-5458	91	10	dmf	dmf	PROPN
dpc-5458	91	11	throughout	throughout	ADP
dpc-5458	91	12	the	the	DET
dpc-5458	91	13	observation	observation	NOUN
dpc-5458	91	14	period	period	NOUN
dpc-5458	91	15	,	,	PUNCT
dpc-5458	91	16	with	with	ADP
dpc-5458	91	17	mean	mean	ADJ
dpc-5458	91	18	pasi	pasi	NOUN
dpc-5458	91	19	decreasing	decrease	VERB
dpc-5458	91	20	from	from	ADP
dpc-5458	91	21	8.9	8.9	NUM
dpc-5458	91	22	to	to	ADP
dpc-5458	91	23	4.3	4.3	NUM
dpc-5458	91	24	(	(	PUNCT
dpc-5458	91	25	p<0.001	p<0.001	ADJ
dpc-5458	91	26	,	,	PUNCT
dpc-5458	91	27	table	table	NOUN
dpc-5458	91	28	2	2	NUM
dpc-5458	91	29	,	,	PUNCT
dpc-5458	91	30	figure	figure	NOUN
dpc-5458	91	31	1	1	NUM
dpc-5458	91	32	)	)	PUNCT
dpc-5458	91	33	.	.	PUNCT
dpc-5458	92	1	at	at	ADP
dpc-5458	92	2	48	48	NUM
dpc-5458	92	3	weeks	week	NOUN
dpc-5458	92	4	,	,	PUNCT
dpc-5458	92	5	the	the	DET
dpc-5458	92	6	percentage	percentage	NOUN
dpc-5458	92	7	of	of	ADP
dpc-5458	92	8	patients	patient	NOUN
dpc-5458	92	9	who	who	PRON
dpc-5458	92	10	achieved	achieve	VERB
dpc-5458	92	11	pasi	pasi	NOUN
dpc-5458	92	12	50	50	NUM
dpc-5458	92	13	was	be	AUX
dpc-5458	92	14	56.8	56.8	NUM
dpc-5458	92	15	%	%	NOUN
dpc-5458	92	16	,	,	PUNCT
dpc-5458	92	17	while	while	SCONJ
dpc-5458	92	18	36.5	36.5	NUM
dpc-5458	92	19	%	%	NOUN
dpc-5458	92	20	achieved	achieve	VERB
dpc-5458	92	21	pasi	pasi	NOUN
dpc-5458	92	22	75	75	NUM
dpc-5458	92	23	(	(	PUNCT
dpc-5458	92	24	table	table	NOUN
dpc-5458	92	25	3	3	NUM
dpc-5458	92	26	,	,	PUNCT
dpc-5458	92	27	figure	figure	NOUN
dpc-5458	92	28	2	2	NUM
dpc-5458	92	29	)	)	PUNCT
dpc-5458	92	30	.	.	PUNCT
dpc-5458	93	1	the	the	DET
dpc-5458	93	2	mean	mean	ADJ
dpc-5458	93	3	treatment	treatment	NOUN
dpc-5458	93	4	duration	duration	NOUN
dpc-5458	93	5	was	be	AUX
dpc-5458	93	6	6.9	6.9	NUM
dpc-5458	93	7	(	(	PUNCT
dpc-5458	93	8	±4.9	±4.9	PROPN
dpc-5458	93	9	)	)	PUNCT
dpc-5458	93	10	months	month	NOUN
dpc-5458	93	11	,	,	PUNCT
dpc-5458	93	12	ranging	range	VERB
dpc-5458	93	13	from	from	ADP
dpc-5458	93	14	0	0	NUM
dpc-5458	93	15	to	to	ADP
dpc-5458	93	16	12	12	NUM
dpc-5458	93	17	months	month	NOUN
dpc-5458	93	18	,	,	PUNCT
dpc-5458	93	19	reflecting	reflect	VERB
dpc-5458	93	20	a	a	DET
dpc-5458	93	21	dropout	dropout	NOUN
dpc-5458	93	22	rate	rate	NOUN
dpc-5458	93	23	of	of	ADP
dpc-5458	93	24	62.8	62.8	NUM
dpc-5458	93	25	%	%	NOUN
dpc-5458	93	26	.	.	PUNCT
dpc-5458	94	1	the	the	DET
dpc-5458	94	2	main	main	ADJ
dpc-5458	94	3	reasons	reason	NOUN
dpc-5458	94	4	for	for	ADP
dpc-5458	94	5	discontinuing	discontinue	VERB
dpc-5458	94	6	dmf	dmf	PROPN
dpc-5458	94	7	treatment	treatment	NOUN
dpc-5458	94	8	were	be	AUX
dpc-5458	94	9	the	the	DET
dpc-5458	94	10	appearance	appearance	NOUN
dpc-5458	94	11	of	of	ADP
dpc-5458	94	12	adverse	adverse	ADJ
dpc-5458	94	13	events	event	NOUN
dpc-5458	94	14	(	(	PUNCT
dpc-5458	94	15	61	61	NUM
dpc-5458	94	16	patients	patient	NOUN
dpc-5458	94	17	,	,	PUNCT
dpc-5458	94	18	41.2	41.2	NUM
dpc-5458	94	19	%	%	NOUN
dpc-5458	94	20	)	)	PUNCT
dpc-5458	94	21	and	and	CCONJ
dpc-5458	94	22	inefficacy	inefficacy	NOUN
dpc-5458	94	23	(	(	PUNCT
dpc-5458	94	24	28	28	NUM
dpc-5458	94	25	patients	patient	NOUN
dpc-5458	94	26	,	,	PUNCT
dpc-5458	94	27	18.9	18.9	NUM
dpc-5458	94	28	%	%	NOUN
dpc-5458	94	29	)	)	PUNCT
dpc-5458	94	30	.	.	PUNCT
dpc-5458	95	1	most	most	ADJ
dpc-5458	95	2	adverse	adverse	ADJ
dpc-5458	95	3	events	event	NOUN
dpc-5458	95	4	occurred	occur	VERB
dpc-5458	95	5	within	within	ADP
dpc-5458	95	6	the	the	DET
dpc-5458	95	7	first	first	ADJ
dpc-5458	95	8	12	12	NUM
dpc-5458	95	9	weeks	week	NOUN
dpc-5458	95	10	of	of	ADP
dpc-5458	95	11	treatment	treatment	NOUN
dpc-5458	95	12	(	(	PUNCT
dpc-5458	95	13	39/61	39/61	NUM
dpc-5458	95	14	,	,	PUNCT
dpc-5458	95	15	63.9	63.9	NUM
dpc-5458	95	16	%	%	NOUN
dpc-5458	95	17	versus	versus	ADP
dpc-5458	95	18	22/6	22/6	NOUN
dpc-5458	95	19	,	,	PUNCT
dpc-5458	95	20	36.1	36.1	NUM
dpc-5458	95	21	%	%	NOUN
dpc-5458	95	22	after	after	ADP
dpc-5458	95	23	12	12	NUM
dpc-5458	95	24	weeks	week	NOUN
dpc-5458	95	25	,	,	PUNCT
dpc-5458	95	26	p<0.001	p<0.001	PROPN
dpc-5458	95	27	)	)	PUNCT
dpc-5458	95	28	.	.	PUNCT
dpc-5458	96	1	interestingly	interestingly	ADV
dpc-5458	96	2	,	,	PUNCT
dpc-5458	96	3	logistic	logistic	ADJ
dpc-5458	96	4	regression	regression	NOUN
dpc-5458	96	5	analysis	analysis	NOUN
dpc-5458	96	6	showed	show	VERB
dpc-5458	96	7	that	that	SCONJ
dpc-5458	96	8	the	the	DET
dpc-5458	96	9	naïve	naïve	ADJ
dpc-5458	96	10	status	status	NOUN
dpc-5458	96	11	of	of	ADP
dpc-5458	96	12	patients	patient	NOUN
dpc-5458	96	13	as	as	ADV
dpc-5458	96	14	well	well	ADV
dpc-5458	96	15	as	as	ADP
dpc-5458	96	16	prior	prior	ADJ
dpc-5458	96	17	treatments	treatment	NOUN
dpc-5458	96	18	(	(	PUNCT
dpc-5458	96	19	experienced	experienced	ADJ
dpc-5458	96	20	)	)	PUNCT
dpc-5458	96	21	did	do	AUX
dpc-5458	96	22	not	not	PART
dpc-5458	96	23	influence	influence	VERB
dpc-5458	96	24	treatment	treatment	NOUN
dpc-5458	96	25	outcomes	outcome	NOUN
dpc-5458	96	26	with	with	ADP
dpc-5458	96	27	dmf	dmf	PROPN
dpc-5458	96	28	,	,	PUNCT
dpc-5458	96	29	as	as	SCONJ
dpc-5458	96	30	observed	observe	VERB
dpc-5458	96	31	for	for	ADP
dpc-5458	96	32	the	the	DET
dpc-5458	96	33	mean	mean	ADJ
dpc-5458	96	34	pasi	pasi	NOUN
dpc-5458	96	35	and	and	CCONJ
dpc-5458	96	36	pasi	pasi	VERB
dpc-5458	96	37	50	50	NUM
dpc-5458	96	38	and	and	CCONJ
dpc-5458	96	39	pasi	pasi	NOUN
dpc-5458	96	40	75	75	NUM
dpc-5458	96	41	(	(	PUNCT
dpc-5458	96	42	table	table	NOUN
dpc-5458	96	43	4	4	NUM
dpc-5458	96	44	)	)	PUNCT
dpc-5458	96	45	.	.	PUNCT
dpc-5458	97	1	the	the	DET
dpc-5458	97	2	analysis	analysis	NOUN
dpc-5458	97	3	also	also	ADV
dpc-5458	97	4	showed	show	VERB
dpc-5458	97	5	that	that	SCONJ
dpc-5458	97	6	a	a	DET
dpc-5458	97	7	longer	long	ADJ
dpc-5458	97	8	duration	duration	NOUN
dpc-5458	97	9	of	of	ADP
dpc-5458	97	10	psoriasis	psoriasis	NOUN
dpc-5458	97	11	was	be	AUX
dpc-5458	97	12	associated	associate	VERB
dpc-5458	97	13	with	with	ADP
dpc-5458	97	14	a	a	DET
dpc-5458	97	15	higher	high	ADJ
dpc-5458	97	16	frequency	frequency	NOUN
dpc-5458	97	17	of	of	ADP
dpc-5458	97	18	adverse	adverse	ADJ
dpc-5458	97	19	events	event	NOUN
dpc-5458	97	20	upon	upon	SCONJ
dpc-5458	97	21	starting	start	VERB
dpc-5458	97	22	treatment	treatment	NOUN
dpc-5458	97	23	with	with	ADP
dpc-5458	97	24	dmf	dmf	PROPN
dpc-5458	97	25	.	.	PUNCT
dpc-5458	98	1	dmf	dmf	PROPN
dpc-5458	98	2	treatment	treatment	NOUN
dpc-5458	98	3	was	be	AUX
dpc-5458	98	4	significantly	significantly	ADV
dpc-5458	98	5	more	more	ADV
dpc-5458	98	6	effective	effective	ADJ
dpc-5458	98	7	in	in	ADP
dpc-5458	98	8	patients	patient	NOUN
dpc-5458	98	9	with	with	ADP
dpc-5458	98	10	a	a	DET
dpc-5458	98	11	disease	disease	NOUN
dpc-5458	98	12	duration	duration	NOUN
dpc-5458	98	13	of	of	ADP
dpc-5458	98	14	less	less	ADJ
dpc-5458	98	15	than	than	ADP
dpc-5458	98	16	five	five	NUM
dpc-5458	98	17	years	year	NOUN
dpc-5458	98	18	after	after	ADP
dpc-5458	98	19	24	24	NUM
dpc-5458	98	20	and	and	CCONJ
dpc-5458	98	21	48	48	NUM
dpc-5458	98	22	weeks	week	NOUN
dpc-5458	98	23	than	than	ADP
dpc-5458	98	24	in	in	ADP
dpc-5458	98	25	patients	patient	NOUN
dpc-5458	98	26	with	with	ADP
dpc-5458	98	27	a	a	DET
dpc-5458	98	28	disease	disease	NOUN
dpc-5458	98	29	duration	duration	NOUN
dpc-5458	98	30	of	of	ADP
dpc-5458	98	31	5–10	5–10	ADJ
dpc-5458	98	32	or	or	CCONJ
dpc-5458	98	33	more	more	ADJ
dpc-5458	98	34	than	than	ADP
dpc-5458	98	35	10	10	NUM
dpc-5458	98	36	years	year	NOUN
dpc-5458	98	37	(	(	PUNCT
dpc-5458	98	38	p=0.04	p=0.04	NOUN
dpc-5458	98	39	and	and	CCONJ
dpc-5458	98	40	p=0.032	p=0.032	NUM
dpc-5458	98	41	;	;	PUNCT
dpc-5458	98	42	table	table	NOUN
dpc-5458	98	43	5	5	NUM
dpc-5458	98	44	)	)	PUNCT
dpc-5458	98	45	.	.	PUNCT
dpc-5458	99	1	furthermore	furthermore	ADV
dpc-5458	99	2	,	,	PUNCT
dpc-5458	99	3	the	the	DET
dpc-5458	99	4	treatment	treatment	NOUN
dpc-5458	99	5	with	with	ADP
dpc-5458	99	6	dmf	dmf	PROPN
dpc-5458	99	7	was	be	AUX
dpc-5458	99	8	significantly	significantly	ADV
dpc-5458	99	9	more	more	ADV
dpc-5458	99	10	effective	effective	ADJ
dpc-5458	99	11	in	in	ADP
dpc-5458	99	12	patients	patient	NOUN
dpc-5458	99	13	whose	whose	DET
dpc-5458	99	14	disease	disease	NOUN
dpc-5458	99	15	onset	onset	VERB
dpc-5458	99	16	was	be	AUX
dpc-5458	99	17	less	less	ADJ
dpc-5458	99	18	than	than	ADP
dpc-5458	99	19	10	10	NUM
dpc-5458	99	20	years	year	NOUN
dpc-5458	99	21	at	at	ADP
dpc-5458	99	22	12	12	NUM
dpc-5458	99	23	(	(	PUNCT
dpc-5458	99	24	p=0.041	p=0.041	NOUN
dpc-5458	99	25	)	)	PUNCT
dpc-5458	99	26	,	,	PUNCT
dpc-5458	99	27	24	24	NUM
dpc-5458	99	28	(	(	PUNCT
dpc-5458	99	29	p=0.011	p=0.011	X
dpc-5458	99	30	)	)	PUNCT
dpc-5458	99	31	,	,	PUNCT
dpc-5458	99	32	and	and	CCONJ
dpc-5458	99	33	48	48	NUM
dpc-5458	99	34	weeks	week	NOUN
dpc-5458	99	35	(	(	PUNCT
dpc-5458	99	36	p=0.009	p=0.009	X
dpc-5458	99	37	)	)	PUNCT
dpc-5458	99	38	(	(	PUNCT
dpc-5458	99	39	table	table	NOUN
dpc-5458	99	40	5	5	NUM
dpc-5458	99	41	,	,	PUNCT
dpc-5458	99	42	figure	figure	NOUN
dpc-5458	99	43	3	3	NUM
dpc-5458	99	44	)	)	PUNCT
dpc-5458	99	45	.	.	PUNCT
dpc-5458	100	1	pasi	pasi	NOUN
dpc-5458	100	2	50	50	NUM
dpc-5458	100	3	and	and	CCONJ
dpc-5458	100	4	pasi	pasi	NOUN
dpc-5458	100	5	75	75	NUM
dpc-5458	100	6	responses	response	NOUN
dpc-5458	100	7	were	be	AUX
dpc-5458	100	8	comparable	comparable	ADJ
dpc-5458	100	9	between	between	ADP
dpc-5458	100	10	biologic	biologic	NOUN
dpc-5458	100	11	/	/	SYM
dpc-5458	100	12	systemic	systemic	ADJ
dpc-5458	100	13	-	-	PUNCT
dpc-5458	100	14	naïve	naïve	ADJ
dpc-5458	100	15	and	and	CCONJ
dpc-5458	100	16	previously	previously	ADV
dpc-5458	100	17	treated	treat	VERB
dpc-5458	100	18	patients	patient	NOUN
dpc-5458	100	19	at	at	ADP
dpc-5458	100	20	each	each	DET
dpc-5458	100	21	time	time	NOUN
dpc-5458	100	22	point	point	NOUN
dpc-5458	100	23	,	,	PUNCT
dpc-5458	100	24	with	with	ADP
dpc-5458	100	25	no	no	DET
dpc-5458	100	26	statistically	statistically	ADV
dpc-5458	100	27	significant	significant	ADJ
dpc-5458	100	28	difference	difference	NOUN
dpc-5458	100	29	observed	observe	VERB
dpc-5458	100	30	(	(	PUNCT
dpc-5458	100	31	all	all	DET
dpc-5458	100	32	p	p	NOUN
dpc-5458	100	33	-	-	PUNCT
dpc-5458	100	34	values	value	NOUN
dpc-5458	100	35	of	of	ADP
dpc-5458	100	36	t	t	NOUN
dpc-5458	100	37	-	-	PUNCT
dpc-5458	100	38	test	test	NOUN
dpc-5458	100	39	>	>	NOUN
dpc-5458	100	40	0.1	0.1	NUM
dpc-5458	100	41	;	;	PUNCT
dpc-5458	100	42	table	table	NOUN
dpc-5458	100	43	1	1	NUM
dpc-5458	100	44	)	)	PUNCT
dpc-5458	100	45	.	.	PUNCT
dpc-5458	101	1	disease	disease	NOUN
dpc-5458	101	2	duration	duration	NOUN
dpc-5458	101	3	,	,	PUNCT
dpc-5458	101	4	bmi	bmi	PROPN
dpc-5458	101	5	≥30	≥30	PROPN
dpc-5458	101	6	,	,	PUNCT
dpc-5458	101	7	maximum	maximum	ADJ
dpc-5458	101	8	dosage	dosage	NOUN
dpc-5458	101	9	,	,	PUNCT
dpc-5458	101	10	and	and	CCONJ
dpc-5458	101	11	number	number	NOUN
dpc-5458	101	12	of	of	ADP
dpc-5458	101	13	comorbidities	comorbiditie	NOUN
dpc-5458	101	14	did	do	AUX
dpc-5458	101	15	not	not	PART
dpc-5458	101	16	account	account	VERB
dpc-5458	101	17	for	for	ADP
dpc-5458	101	18	significant	significant	ADJ
dpc-5458	101	19	differences	difference	NOUN
dpc-5458	101	20	in	in	ADP
dpc-5458	101	21	achieving	achieve	VERB
dpc-5458	101	22	pasi	pasi	NOUN
dpc-5458	101	23	50	50	NUM
dpc-5458	101	24	or	or	CCONJ
dpc-5458	101	25	75	75	NUM
dpc-5458	101	26	at	at	ADP
dpc-5458	101	27	three	three	NUM
dpc-5458	101	28	months	month	NOUN
dpc-5458	101	29	in	in	ADP
dpc-5458	101	30	the	the	DET
dpc-5458	101	31	logistic	logistic	ADJ
dpc-5458	101	32	regression	regression	NOUN
dpc-5458	101	33	model	model	NOUN
dpc-5458	101	34	.	.	PUNCT
dpc-5458	102	1	discussion	discussion	NOUN
dpc-5458	102	2	conventional	conventional	ADJ
dpc-5458	102	3	systemic	systemic	ADJ
dpc-5458	102	4	treatment	treatment	NOUN
dpc-5458	102	5	of	of	ADP
dpc-5458	102	6	psoriasis	psoriasis	NOUN
dpc-5458	102	7	relies	rely	VERB
dpc-5458	102	8	on	on	ADP
dpc-5458	102	9	the	the	DET
dpc-5458	102	10	use	use	NOUN
dpc-5458	102	11	of	of	ADP
dpc-5458	102	12	mtx	mtx	NOUN
dpc-5458	102	13	,	,	PUNCT
dpc-5458	102	14	cyclosporin	cyclosporin	NOUN
dpc-5458	102	15	,	,	PUNCT
dpc-5458	102	16	and	and	CCONJ
dpc-5458	102	17	acitretin	acitretin	VERB
dpc-5458	102	18	[	[	X
dpc-5458	102	19	7	7	NUM
dpc-5458	102	20	]	]	PUNCT
dpc-5458	102	21	.	.	PUNCT
dpc-5458	103	1	dmf	dmf	PROPN
dpc-5458	103	2	is	be	AUX
dpc-5458	103	3	an	an	DET
dpc-5458	103	4	fae	fae	NOUN
dpc-5458	103	5	that	that	PRON
dpc-5458	103	6	has	have	AUX
dpc-5458	103	7	been	be	AUX
dpc-5458	103	8	used	use	VERB
dpc-5458	103	9	as	as	ADP
dpc-5458	103	10	a	a	DET
dpc-5458	103	11	first	first	ADJ
dpc-5458	103	12	-	-	PUNCT
dpc-5458	103	13	line	line	NOUN
dpc-5458	103	14	systemic	systemic	ADJ
dpc-5458	103	15	treatment	treatment	NOUN
dpc-5458	103	16	for	for	ADP
dpc-5458	103	17	psoriasis	psoriasis	NOUN
dpc-5458	103	18	in	in	ADP
dpc-5458	103	19	recent	recent	ADJ
dpc-5458	103	20	years	year	NOUN
dpc-5458	103	21	because	because	SCONJ
dpc-5458	103	22	of	of	ADP
dpc-5458	103	23	its	its	PRON
dpc-5458	103	24	good	good	ADJ
dpc-5458	103	25	safety	safety	NOUN
dpc-5458	103	26	profile	profile	NOUN
dpc-5458	103	27	for	for	ADP
dpc-5458	103	28	long	long	ADJ
dpc-5458	103	29	-	-	PUNCT
dpc-5458	103	30	term	term	NOUN
dpc-5458	103	31	therapy	therapy	NOUN
dpc-5458	103	32	[	[	X
dpc-5458	103	33	21	21	NUM
dpc-5458	103	34	]	]	PUNCT
dpc-5458	103	35	.	.	PUNCT
dpc-5458	104	1	in	in	ADP
dpc-5458	104	2	contrast	contrast	NOUN
dpc-5458	104	3	to	to	ADP
dpc-5458	104	4	cyclosporin	cyclosporin	NOUN
dpc-5458	104	5	,	,	PUNCT
dpc-5458	104	6	mtx	mtx	NOUN
dpc-5458	104	7	,	,	PUNCT
dpc-5458	104	8	and	and	CCONJ
dpc-5458	104	9	acitretin	acitretin	PROPN
dpc-5458	104	10	,	,	PUNCT
dpc-5458	104	11	which	which	PRON
dpc-5458	104	12	are	be	AUX
dpc-5458	104	13	associated	associate	VERB
dpc-5458	104	14	with	with	ADP
dpc-5458	104	15	several	several	ADJ
dpc-5458	104	16	contraindications	contraindication	NOUN
dpc-5458	104	17	,	,	PUNCT
dpc-5458	104	18	potentially	potentially	ADV
dpc-5458	104	19	severe	severe	ADJ
dpc-5458	104	20	adverse	adverse	ADJ
dpc-5458	104	21	events	event	NOUN
dpc-5458	104	22	,	,	PUNCT
dpc-5458	104	23	and	and	CCONJ
dpc-5458	104	24	cumulative	cumulative	ADJ
dpc-5458	104	25	organ	organ	NOUN
dpc-5458	104	26	toxicity	toxicity	NOUN
dpc-5458	104	27	[	[	X
dpc-5458	104	28	22–24	22–24	NUM
dpc-5458	104	29	]	]	PUNCT
dpc-5458	104	30	,	,	PUNCT
dpc-5458	104	31	dmf	dmf	PROPN
dpc-5458	104	32	predominantly	predominantly	ADV
dpc-5458	104	33	causes	cause	VERB
dpc-5458	104	34	non	non	PRON
dpc-5458	104	35	serious	serious	ADJ
dpc-5458	104	36	and	and	CCONJ
dpc-5458	104	37	self	self	NOUN
dpc-5458	104	38	-	-	PUNCT
dpc-5458	104	39	limiting	limit	VERB
dpc-5458	104	40	side	side	NOUN
dpc-5458	104	41	effects	effect	NOUN
dpc-5458	104	42	[	[	X
dpc-5458	104	43	25	25	NUM
dpc-5458	104	44	]	]	PUNCT
dpc-5458	104	45	.	.	PUNCT
dpc-5458	105	1	mechanistically	mechanistically	ADV
dpc-5458	105	2	,	,	PUNCT
dpc-5458	105	3	original	original	ADJ
dpc-5458	105	4	article	article	NOUN
dpc-5458	105	5	|	|	ADV
dpc-5458	105	6	dermatol	dermatol	ADJ
dpc-5458	105	7	pract	pract	NOUN
dpc-5458	105	8	concept	concept	NOUN
dpc-5458	105	9	.	.	PUNCT
dpc-5458	106	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	106	2	5	5	NUM
dpc-5458	106	3	figure	figure	NOUN
dpc-5458	106	4	1	1	NUM
dpc-5458	106	5	.	.	PUNCT
dpc-5458	107	1	mean	mean	PROPN
dpc-5458	107	2	pasi	pasi	PROPN
dpc-5458	107	3	analyzed	analyze	VERB
dpc-5458	107	4	using	use	VERB
dpc-5458	107	5	the	the	DET
dpc-5458	107	6	last	last	ADJ
dpc-5458	107	7	observation	observation	NOUN
dpc-5458	107	8	carried	carry	VERB
dpc-5458	107	9	forward	forward	ADV
dpc-5458	107	10	analysis	analysis	NOUN
dpc-5458	107	11	(	(	PUNCT
dpc-5458	107	12	locf	locf	PROPN
dpc-5458	107	13	)	)	PUNCT
dpc-5458	107	14	.	.	PUNCT
dpc-5458	108	1	the	the	DET
dpc-5458	108	2	figure	figure	NOUN
dpc-5458	108	3	shows	show	VERB
dpc-5458	108	4	the	the	DET
dpc-5458	108	5	decline	decline	NOUN
dpc-5458	108	6	in	in	ADP
dpc-5458	108	7	pasi	pasi	NOUN
dpc-5458	108	8	over	over	ADP
dpc-5458	108	9	follow	follow	NOUN
dpc-5458	108	10	-	-	PUNCT
dpc-5458	108	11	up	up	ADP
dpc-5458	108	12	visits	visit	NOUN
dpc-5458	108	13	.	.	PUNCT
dpc-5458	109	1	table	table	NOUN
dpc-5458	109	2	2	2	NUM
dpc-5458	109	3	.	.	PUNCT
dpc-5458	110	1	mean	mean	VERB
dpc-5458	110	2	pasi	pasi	ADJ
dpc-5458	110	3	analysis	analysis	NOUN
dpc-5458	110	4	at	at	ADP
dpc-5458	110	5	each	each	DET
dpc-5458	110	6	visit	visit	NOUN
dpc-5458	110	7	(	(	PUNCT
dpc-5458	110	8	as	as	ADP
dpc-5458	110	9	observed	observe	VERB
dpc-5458	110	10	)	)	PUNCT
dpc-5458	110	11	and	and	CCONJ
dpc-5458	110	12	mean	mean	VERB
dpc-5458	110	13	pasi	pasi	NOUN
dpc-5458	110	14	analyzed	analyze	VERB
dpc-5458	110	15	using	use	VERB
dpc-5458	110	16	the	the	DET
dpc-5458	110	17	last	last	ADJ
dpc-5458	110	18	observation	observation	NOUN
dpc-5458	110	19	carried	carry	VERB
dpc-5458	110	20	forward	forward	ADV
dpc-5458	110	21	analysis	analysis	NOUN
dpc-5458	110	22	(	(	PUNCT
dpc-5458	110	23	locf	locf	PROPN
dpc-5458	110	24	)	)	PUNCT
dpc-5458	110	25	.	.	PUNCT
dpc-5458	111	1	pasi	pasi	NOUN
dpc-5458	111	2	analysis	analysis	NOUN
dpc-5458	111	3	mean	mean	NOUN
dpc-5458	111	4	(	(	PUNCT
dpc-5458	111	5	±sd	±sd	NOUN
dpc-5458	111	6	)	)	PUNCT
dpc-5458	111	7	paired	pair	VERB
dpc-5458	111	8	t	t	NOUN
dpc-5458	111	9	-	-	PUNCT
dpc-5458	111	10	test	test	NOUN
dpc-5458	111	11	p	p	NOUN
dpc-5458	111	12	-	-	PUNCT
dpc-5458	111	13	value	value	NOUN
dpc-5458	111	14	as	as	SCONJ
dpc-5458	111	15	observed	observe	VERB
dpc-5458	111	16	analysis	analysis	NOUN
dpc-5458	111	17	baseline	baseline	NOUN
dpc-5458	111	18	vs	vs	ADP
dpc-5458	111	19	week	week	NOUN
dpc-5458	111	20	4	4	NUM
dpc-5458	111	21	n=141	n=141	NOUN
dpc-5458	111	22	,	,	PUNCT
dpc-5458	111	23	9.0	9.0	NUM
dpc-5458	111	24	(	(	PUNCT
dpc-5458	111	25	±4.2	±4.2	PROPN
dpc-5458	111	26	)	)	PUNCT
dpc-5458	111	27	n=141	n=141	NOUN
dpc-5458	111	28	,	,	PUNCT
dpc-5458	111	29	7.6	7.6	NUM
dpc-5458	111	30	(	(	PUNCT
dpc-5458	111	31	±4.1	±4.1	PROPN
dpc-5458	111	32	)	)	PUNCT
dpc-5458	111	33	<	<	X
dpc-5458	111	34	0.001	0.001	NUM
dpc-5458	111	35	baseline	baseline	NOUN
dpc-5458	111	36	vs	vs	ADP
dpc-5458	111	37	week	week	NOUN
dpc-5458	111	38	8	8	NUM
dpc-5458	111	39	n=82	n=82	NOUN
dpc-5458	111	40	,	,	PUNCT
dpc-5458	111	41	9.0	9.0	NUM
dpc-5458	111	42	(	(	PUNCT
dpc-5458	111	43	±4.5	±4.5	PROPN
dpc-5458	111	44	)	)	PUNCT
dpc-5458	111	45	n=82	n=82	NOUN
dpc-5458	111	46	,	,	PUNCT
dpc-5458	111	47	6.4	6.4	NUM
dpc-5458	111	48	(	(	PUNCT
dpc-5458	111	49	±5.0	±5.0	PROPN
dpc-5458	111	50	)	)	PUNCT
dpc-5458	111	51	<	<	X
dpc-5458	111	52	0.001	0.001	NUM
dpc-5458	111	53	baseline	baseline	NOUN
dpc-5458	111	54	vs	vs	ADP
dpc-5458	111	55	week	week	NOUN
dpc-5458	111	56	12	12	NUM
dpc-5458	111	57	n=101	n=101	PROPN
dpc-5458	111	58	,	,	PUNCT
dpc-5458	111	59	9.5	9.5	NUM
dpc-5458	111	60	(	(	PUNCT
dpc-5458	111	61	±4.3	±4.3	NOUN
dpc-5458	111	62	)	)	PUNCT
dpc-5458	111	63	n=101	n=101	PROPN
dpc-5458	111	64	,	,	PUNCT
dpc-5458	111	65	5.1	5.1	NUM
dpc-5458	111	66	(	(	PUNCT
dpc-5458	111	67	±4.0	±4.0	NOUN
dpc-5458	111	68	)	)	PUNCT
dpc-5458	111	69	<	<	X
dpc-5458	111	70	0.001	0.001	NUM
dpc-5458	111	71	baseline	baseline	NOUN
dpc-5458	111	72	vs	vs	ADP
dpc-5458	111	73	week	week	NOUN
dpc-5458	111	74	24	24	NUM
dpc-5458	111	75	n=87	n=87	PROPN
dpc-5458	111	76	,	,	PUNCT
dpc-5458	111	77	9.6	9.6	NUM
dpc-5458	111	78	(	(	PUNCT
dpc-5458	111	79	±4.2	±4.2	PROPN
dpc-5458	111	80	)	)	PUNCT
dpc-5458	111	81	n=87	n=87	PROPN
dpc-5458	111	82	,	,	PUNCT
dpc-5458	111	83	3.3	3.3	NUM
dpc-5458	111	84	(	(	PUNCT
dpc-5458	111	85	±4.0	±4.0	NOUN
dpc-5458	111	86	)	)	PUNCT
dpc-5458	111	87	<	<	X
dpc-5458	111	88	0.001	0.001	NUM
dpc-5458	111	89	baseline	baseline	NOUN
dpc-5458	111	90	vs	vs	ADP
dpc-5458	111	91	week	week	NOUN
dpc-5458	111	92	48	48	NUM
dpc-5458	111	93	n=54	n=54	NOUN
dpc-5458	111	94	,	,	PUNCT
dpc-5458	111	95	10.0	10.0	NUM
dpc-5458	111	96	(	(	PUNCT
dpc-5458	111	97	±4.3	±4.3	NOUN
dpc-5458	111	98	)	)	PUNCT
dpc-5458	111	99	n=54	n=54	NOUN
dpc-5458	111	100	,	,	PUNCT
dpc-5458	111	101	1.8	1.8	NUM
dpc-5458	111	102	(	(	PUNCT
dpc-5458	111	103	±2.3	±2.3	PROPN
dpc-5458	111	104	)	)	PUNCT
dpc-5458	111	105	<	<	X
dpc-5458	111	106	0.001	0.001	NUM
dpc-5458	111	107	locf	locf	ADP
dpc-5458	111	108	analysis	analysis	NOUN
dpc-5458	111	109	baseline	baseline	NOUN
dpc-5458	111	110	vs	vs	ADP
dpc-5458	111	111	week	week	NOUN
dpc-5458	111	112	4	4	NUM
dpc-5458	111	113	8.9	8.9	NUM
dpc-5458	111	114	(	(	PUNCT
dpc-5458	111	115	±4.2	±4.2	NOUN
dpc-5458	111	116	)	)	PUNCT
dpc-5458	111	117	7.6	7.6	NUM
dpc-5458	111	118	(	(	PUNCT
dpc-5458	111	119	±4.1	±4.1	PROPN
dpc-5458	111	120	)	)	PUNCT
dpc-5458	111	121	<	<	X
dpc-5458	111	122	0.001	0.001	NUM
dpc-5458	111	123	baseline	baseline	NOUN
dpc-5458	111	124	vs	vs	ADP
dpc-5458	111	125	week	week	NOUN
dpc-5458	111	126	8	8	NUM
dpc-5458	111	127	8.9	8.9	NUM
dpc-5458	111	128	(	(	PUNCT
dpc-5458	111	129	±4.2	±4.2	PROPN
dpc-5458	111	130	)	)	PUNCT
dpc-5458	111	131	6.9	6.9	NUM
dpc-5458	111	132	(	(	PUNCT
dpc-5458	111	133	±4.1	±4.1	PROPN
dpc-5458	111	134	)	)	PUNCT
dpc-5458	111	135	<	<	X
dpc-5458	111	136	0.001	0.001	NUM
dpc-5458	111	137	baseline	baseline	NOUN
dpc-5458	111	138	vs	vs	ADP
dpc-5458	111	139	week	week	NOUN
dpc-5458	111	140	12	12	NUM
dpc-5458	111	141	8.9	8.9	NUM
dpc-5458	111	142	(	(	PUNCT
dpc-5458	111	143	±4.2	±4.2	PROPN
dpc-5458	111	144	)	)	PUNCT
dpc-5458	111	145	5.7	5.7	NUM
dpc-5458	111	146	(	(	PUNCT
dpc-5458	111	147	±4.1	±4.1	PROPN
dpc-5458	111	148	)	)	PUNCT
dpc-5458	111	149	<	<	X
dpc-5458	111	150	0.001	0.001	NUM
dpc-5458	111	151	baseline	baseline	NOUN
dpc-5458	111	152	vs	vs	ADP
dpc-5458	111	153	week	week	NOUN
dpc-5458	111	154	24	24	NUM
dpc-5458	111	155	8.9	8.9	NUM
dpc-5458	111	156	(	(	PUNCT
dpc-5458	111	157	±4.2	±4.2	NOUN
dpc-5458	111	158	)	)	PUNCT
dpc-5458	111	159	4.7	4.7	NUM
dpc-5458	111	160	(	(	PUNCT
dpc-5458	111	161	±4.6	±4.6	NOUN
dpc-5458	111	162	)	)	PUNCT
dpc-5458	111	163	<	<	X
dpc-5458	111	164	0.001	0.001	NUM
dpc-5458	111	165	baseline	baseline	NOUN
dpc-5458	111	166	vs	vs	ADP
dpc-5458	111	167	week	week	NOUN
dpc-5458	111	168	48	48	NUM
dpc-5458	111	169	8.9	8.9	NUM
dpc-5458	111	170	(	(	PUNCT
dpc-5458	111	171	±4.2	±4.2	NOUN
dpc-5458	111	172	)	)	PUNCT
dpc-5458	111	173	4.3	4.3	NUM
dpc-5458	111	174	(	(	PUNCT
dpc-5458	111	175	±4.7	±4.7	PROPN
dpc-5458	111	176	)	)	PUNCT
dpc-5458	111	177	<	<	X
dpc-5458	111	178	0.001	0.001	NUM
dpc-5458	111	179	abbreviations	abbreviation	NOUN
dpc-5458	111	180	:	:	PUNCT
dpc-5458	111	181	locf	locf	PROPN
dpc-5458	111	182	:	:	PUNCT
dpc-5458	111	183	last	last	ADJ
dpc-5458	111	184	observation	observation	NOUN
dpc-5458	111	185	carried	carry	VERB
dpc-5458	111	186	forward	forward	ADV
dpc-5458	111	187	;	;	PUNCT
dpc-5458	111	188	pasi	pasi	NOUN
dpc-5458	111	189	:	:	PUNCT
dpc-5458	111	190	psoriasis	psoriasis	NOUN
dpc-5458	111	191	area	area	NOUN
dpc-5458	111	192	severity	severity	PROPN
dpc-5458	111	193	index	index	NOUN
dpc-5458	111	194	.	.	PUNCT
dpc-5458	112	1	dmf	dmf	PROPN
dpc-5458	112	2	inhibits	inhibit	VERB
dpc-5458	112	3	nf	nf	PROPN
dpc-5458	112	4	-	-	PUNCT
dpc-5458	112	5	kb	kb	NOUN
dpc-5458	112	6	translocation	translocation	NOUN
dpc-5458	112	7	in	in	ADP
dpc-5458	112	8	fibroblasts	fibroblast	NOUN
dpc-5458	112	9	and	and	CCONJ
dpc-5458	112	10	keratinocytes	keratinocyte	NOUN
dpc-5458	112	11	,	,	PUNCT
dpc-5458	112	12	thereby	thereby	ADV
dpc-5458	112	13	downregulating	downregulate	VERB
dpc-5458	112	14	the	the	DET
dpc-5458	112	15	production	production	NOUN
dpc-5458	112	16	of	of	ADP
dpc-5458	112	17	inflammatory	inflammatory	ADJ
dpc-5458	112	18	cytokines	cytokine	NOUN
dpc-5458	112	19	and	and	CCONJ
dpc-5458	112	20	hindering	hinder	VERB
dpc-5458	112	21	the	the	DET
dpc-5458	112	22	inflammatory	inflammatory	ADJ
dpc-5458	112	23	response	response	NOUN
dpc-5458	112	24	.	.	PUNCT
dpc-5458	113	1	additionally	additionally	ADV
dpc-5458	113	2	,	,	PUNCT
dpc-5458	113	3	dmf	dmf	PROPN
dpc-5458	113	4	increases	increase	VERB
dpc-5458	113	5	the	the	DET
dpc-5458	113	6	proportion	proportion	NOUN
dpc-5458	113	7	of	of	ADP
dpc-5458	113	8	regulatory	regulatory	ADJ
dpc-5458	113	9	t	t	NOUN
dpc-5458	113	10	cells	cell	NOUN
dpc-5458	113	11	relative	relative	ADJ
dpc-5458	113	12	to	to	ADP
dpc-5458	113	13	t	t	PROPN
dpc-5458	113	14	-	-	PUNCT
dpc-5458	113	15	helper	helper	NOUN
dpc-5458	113	16	lymphocytes	lymphocyte	VERB
dpc-5458	113	17	17	17	NUM
dpc-5458	113	18	,	,	PUNCT
dpc-5458	113	19	induces	induce	VERB
dpc-5458	113	20	t	t	NOUN
dpc-5458	113	21	-	-	PUNCT
dpc-5458	113	22	cell	cell	NOUN
dpc-5458	113	23	apoptosis	apoptosis	NOUN
dpc-5458	113	24	,	,	PUNCT
dpc-5458	113	25	and	and	CCONJ
dpc-5458	113	26	inhibits	inhibit	VERB
dpc-5458	113	27	keratinocyte	keratinocyte	NOUN
dpc-5458	113	28	proliferation	proliferation	NOUN
dpc-5458	113	29	[	[	X
dpc-5458	113	30	18	18	NUM
dpc-5458	113	31	]	]	PUNCT
dpc-5458	113	32	.	.	PUNCT
dpc-5458	114	1	our	our	PRON
dpc-5458	114	2	study	study	NOUN
dpc-5458	114	3	showed	show	VERB
dpc-5458	114	4	that	that	SCONJ
dpc-5458	114	5	dmf	dmf	PROPN
dpc-5458	114	6	is	be	AUX
dpc-5458	114	7	a	a	DET
dpc-5458	114	8	valid	valid	ADJ
dpc-5458	114	9	treatment	treatment	NOUN
dpc-5458	114	10	option	option	NOUN
dpc-5458	114	11	for	for	ADP
dpc-5458	114	12	patients	patient	NOUN
dpc-5458	114	13	with	with	ADP
dpc-5458	114	14	moderate	moderate	ADJ
dpc-5458	114	15	psoriasis	psoriasis	NOUN
dpc-5458	114	16	,	,	PUNCT
dpc-5458	114	17	as	as	ADP
dpc-5458	114	18	36.5	36.5	NUM
dpc-5458	114	19	%	%	NOUN
dpc-5458	114	20	of	of	ADP
dpc-5458	114	21	total	total	ADJ
dpc-5458	114	22	patients	patient	NOUN
dpc-5458	114	23	,	,	PUNCT
dpc-5458	114	24	representing	represent	VERB
dpc-5458	114	25	70.4	70.4	NUM
dpc-5458	114	26	%	%	NOUN
dpc-5458	114	27	of	of	ADP
dpc-5458	114	28	those	those	PRON
dpc-5458	114	29	still	still	ADV
dpc-5458	114	30	on	on	ADP
dpc-5458	114	31	treatment	treatment	NOUN
dpc-5458	114	32	at	at	ADP
dpc-5458	114	33	the	the	DET
dpc-5458	114	34	timepoint	timepoint	NOUN
dpc-5458	114	35	,	,	PUNCT
dpc-5458	114	36	achieved	achieve	VERB
dpc-5458	114	37	pasi	pasi	NOUN
dpc-5458	114	38	75	75	NUM
dpc-5458	114	39	at	at	ADP
dpc-5458	114	40	week	week	NOUN
dpc-5458	114	41	48	48	NUM
dpc-5458	114	42	.	.	PUNCT
dpc-5458	115	1	notably	notably	ADV
dpc-5458	115	2	,	,	PUNCT
dpc-5458	115	3	these	these	DET
dpc-5458	115	4	results	result	NOUN
dpc-5458	115	5	were	be	AUX
dpc-5458	115	6	observed	observe	VERB
dpc-5458	115	7	across	across	ADP
dpc-5458	115	8	both	both	PRON
dpc-5458	115	9	treatment	treatment	NOUN
dpc-5458	115	10	-	-	PUNCT
dpc-5458	115	11	naïve	naïve	ADJ
dpc-5458	115	12	and	and	CCONJ
dpc-5458	115	13	previously	previously	ADV
dpc-5458	115	14	treated	treat	VERB
dpc-5458	115	15	individuals	individual	NOUN
dpc-5458	115	16	,	,	PUNCT
dpc-5458	115	17	suggesting	suggest	VERB
dpc-5458	115	18	consistent	consistent	ADJ
dpc-5458	115	19	therapeutic	therapeutic	ADJ
dpc-5458	115	20	benefit	benefit	NOUN
dpc-5458	115	21	irrespective	irrespective	ADV
dpc-5458	115	22	of	of	ADP
dpc-5458	115	23	prior	prior	ADJ
dpc-5458	115	24	systemic	systemic	ADJ
dpc-5458	115	25	exposure	exposure	NOUN
dpc-5458	115	26	.	.	PUNCT
dpc-5458	116	1	our	our	PRON
dpc-5458	116	2	findings	finding	NOUN
dpc-5458	116	3	confirmed	confirm	VERB
dpc-5458	116	4	that	that	SCONJ
dpc-5458	116	5	dmf	dmf	PROPN
dpc-5458	116	6	is	be	AUX
dpc-5458	116	7	a	a	DET
dpc-5458	116	8	slow	slow	ADV
dpc-5458	116	9	-	-	PUNCT
dpc-5458	116	10	acting	act	VERB
dpc-5458	116	11	agent	agent	NOUN
dpc-5458	116	12	that	that	SCONJ
dpc-5458	116	13	,	,	PUNCT
dpc-5458	116	14	although	although	SCONJ
dpc-5458	116	15	starting	start	VERB
dpc-5458	116	16	to	to	PART
dpc-5458	116	17	reduce	reduce	VERB
dpc-5458	116	18	pasi	pasi	NOUN
dpc-5458	116	19	by	by	ADP
dpc-5458	116	20	week	week	NOUN
dpc-5458	116	21	4	4	NUM
dpc-5458	116	22	,	,	PUNCT
dpc-5458	116	23	achieves	achieve	VERB
dpc-5458	116	24	its	its	PRON
dpc-5458	116	25	full	full	ADJ
dpc-5458	116	26	therapeutic	therapeutic	ADJ
dpc-5458	116	27	effect	effect	NOUN
dpc-5458	116	28	only	only	ADV
dpc-5458	116	29	after	after	ADP
dpc-5458	116	30	several	several	ADJ
dpc-5458	116	31	weeks	week	NOUN
dpc-5458	116	32	of	of	ADP
dpc-5458	116	33	treatment	treatment	NOUN
dpc-5458	116	34	.	.	PUNCT
dpc-5458	117	1	the	the	DET
dpc-5458	117	2	dropout	dropout	NOUN
dpc-5458	117	3	rate	rate	NOUN
dpc-5458	117	4	was	be	AUX
dpc-5458	117	5	high	high	ADJ
dpc-5458	117	6	(	(	PUNCT
dpc-5458	117	7	62.8	62.8	NUM
dpc-5458	117	8	%	%	NOUN
dpc-5458	117	9	)	)	PUNCT
dpc-5458	117	10	,	,	PUNCT
dpc-5458	117	11	with	with	ADP
dpc-5458	117	12	the	the	DET
dpc-5458	117	13	primary	primary	ADJ
dpc-5458	117	14	reason	reason	NOUN
dpc-5458	117	15	for	for	ADP
dpc-5458	117	16	discontinuation	discontinuation	NOUN
dpc-5458	117	17	being	be	AUX
dpc-5458	117	18	gastrointestinal	gastrointestinal	ADJ
dpc-5458	117	19	issues	issue	NOUN
dpc-5458	117	20	and	and	CCONJ
dpc-5458	117	21	flushing	flush	VERB
dpc-5458	117	22	.	.	PUNCT
dpc-5458	118	1	although	although	SCONJ
dpc-5458	118	2	these	these	DET
dpc-5458	118	3	adverse	adverse	ADJ
dpc-5458	118	4	events	event	NOUN
dpc-5458	118	5	were	be	AUX
dpc-5458	118	6	mild	mild	ADJ
dpc-5458	118	7	,	,	PUNCT
dpc-5458	118	8	they	they	PRON
dpc-5458	118	9	were	be	AUX
dpc-5458	118	10	not	not	PART
dpc-5458	118	11	tolerated	tolerate	VERB
dpc-5458	118	12	by	by	ADP
dpc-5458	118	13	patients	patient	NOUN
dpc-5458	118	14	.	.	PUNCT
dpc-5458	119	1	however	however	ADV
dpc-5458	119	2	,	,	PUNCT
dpc-5458	119	3	it	it	PRON
dpc-5458	119	4	is	be	AUX
dpc-5458	119	5	important	important	ADJ
dpc-5458	119	6	to	to	PART
dpc-5458	119	7	make	make	VERB
dpc-5458	119	8	a	a	DET
dpc-5458	119	9	distinction	distinction	NOUN
dpc-5458	119	10	between	between	ADP
dpc-5458	119	11	tolerability	tolerability	NOUN
dpc-5458	119	12	and	and	CCONJ
dpc-5458	119	13	safety	safety	NOUN
dpc-5458	119	14	.	.	PUNCT
dpc-5458	120	1	while	while	SCONJ
dpc-5458	120	2	dmf	dmf	PROPN
dpc-5458	120	3	’s	’s	PART
dpc-5458	120	4	adverse	adverse	ADJ
dpc-5458	120	5	events	event	NOUN
dpc-5458	120	6	are	be	AUX
dpc-5458	120	7	frequent	frequent	ADJ
dpc-5458	120	8	and	and	CCONJ
dpc-5458	120	9	may	may	AUX
dpc-5458	120	10	lead	lead	VERB
dpc-5458	120	11	to	to	ADP
dpc-5458	120	12	early	early	ADJ
dpc-5458	120	13	discontinuation	discontinuation	NOUN
dpc-5458	120	14	due	due	ADP
dpc-5458	120	15	to	to	ADP
dpc-5458	120	16	the	the	DET
dpc-5458	120	17	patient	patient	NOUN
dpc-5458	120	18	’s	’s	PART
dpc-5458	120	19	low	low	ADJ
dpc-5458	120	20	tolerability	tolerability	NOUN
dpc-5458	120	21	,	,	PUNCT
dpc-5458	120	22	they	they	PRON
dpc-5458	120	23	are	be	AUX
dpc-5458	120	24	generally	generally	ADV
dpc-5458	120	25	mild	mild	ADJ
dpc-5458	120	26	,	,	PUNCT
dpc-5458	120	27	self	self	NOUN
dpc-5458	120	28	limited	limited	ADJ
dpc-5458	120	29	,	,	PUNCT
dpc-5458	120	30	and	and	CCONJ
dpc-5458	120	31	reversible	reversible	ADJ
dpc-5458	120	32	upon	upon	SCONJ
dpc-5458	120	33	treatment	treatment	NOUN
dpc-5458	120	34	cessation	cessation	NOUN
dpc-5458	120	35	.	.	PUNCT
dpc-5458	121	1	besides	besides	SCONJ
dpc-5458	121	2	6	6	NUM
dpc-5458	121	3	original	original	ADJ
dpc-5458	121	4	article	article	NOUN
dpc-5458	121	5	|	|	ADV
dpc-5458	121	6	dermatol	dermatol	ADJ
dpc-5458	121	7	pract	pract	NOUN
dpc-5458	121	8	concept	concept	NOUN
dpc-5458	121	9	.	.	PUNCT
dpc-5458	122	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	122	2	table	table	NOUN
dpc-5458	122	3	3	3	NUM
dpc-5458	122	4	.	.	PUNCT
dpc-5458	122	5	percentages	percentage	NOUN
dpc-5458	122	6	of	of	ADP
dpc-5458	122	7	patients	patient	NOUN
dpc-5458	122	8	achieving	achieve	VERB
dpc-5458	122	9	pasi	pasi	NOUN
dpc-5458	122	10	50	50	NUM
dpc-5458	122	11	and	and	CCONJ
dpc-5458	122	12	pasi	pasi	NOUN
dpc-5458	122	13	75	75	NUM
dpc-5458	122	14	analyzed	analyze	VERB
dpc-5458	122	15	using	use	VERB
dpc-5458	122	16	the	the	DET
dpc-5458	122	17	last	last	ADJ
dpc-5458	122	18	observation	observation	NOUN
dpc-5458	122	19	carried	carry	VERB
dpc-5458	122	20	forward	forward	ADV
dpc-5458	122	21	(	(	PUNCT
dpc-5458	122	22	locf	locf	PROPN
dpc-5458	122	23	)	)	PUNCT
dpc-5458	122	24	analysis	analysis	NOUN
dpc-5458	122	25	.	.	PUNCT
dpc-5458	123	1	visit	visit	VERB
dpc-5458	123	2	n=148	n=148	PROPN
dpc-5458	123	3	,	,	PUNCT
dpc-5458	123	4	n	n	PROPN
dpc-5458	123	5	(	(	PUNCT
dpc-5458	123	6	%	%	INTJ
dpc-5458	123	7	)	)	PUNCT
dpc-5458	123	8	pasi	pasi	NOUN
dpc-5458	123	9	50	50	NUM
dpc-5458	123	10	4	4	NUM
dpc-5458	123	11	weeks	week	NOUN
dpc-5458	123	12	9	9	NUM
dpc-5458	123	13	(	(	PUNCT
dpc-5458	123	14	6.1	6.1	NUM
dpc-5458	123	15	%	%	NOUN
dpc-5458	123	16	)	)	PUNCT
dpc-5458	123	17	8	8	NUM
dpc-5458	123	18	weeks	week	NOUN
dpc-5458	123	19	14	14	NUM
dpc-5458	123	20	(	(	PUNCT
dpc-5458	123	21	9.5	9.5	NUM
dpc-5458	123	22	%	%	NOUN
dpc-5458	123	23	)	)	PUNCT
dpc-5458	123	24	12	12	NUM
dpc-5458	123	25	weeks	week	NOUN
dpc-5458	123	26	46	46	NUM
dpc-5458	123	27	(	(	PUNCT
dpc-5458	123	28	31.1	31.1	NUM
dpc-5458	123	29	%	%	NOUN
dpc-5458	123	30	)	)	PUNCT
dpc-5458	123	31	24	24	NUM
dpc-5458	123	32	weeks	week	NOUN
dpc-5458	123	33	75	75	NUM
dpc-5458	123	34	(	(	PUNCT
dpc-5458	123	35	50.7	50.7	NUM
dpc-5458	123	36	%	%	NOUN
dpc-5458	123	37	)	)	PUNCT
dpc-5458	123	38	48	48	NUM
dpc-5458	123	39	weeks	week	NOUN
dpc-5458	123	40	84	84	NUM
dpc-5458	123	41	(	(	PUNCT
dpc-5458	123	42	56.8	56.8	NUM
dpc-5458	123	43	%	%	NOUN
dpc-5458	123	44	)	)	PUNCT
dpc-5458	123	45	pasi	pasi	NOUN
dpc-5458	123	46	75	75	NUM
dpc-5458	123	47	4	4	NUM
dpc-5458	123	48	weeks	week	NOUN
dpc-5458	123	49	4	4	NUM
dpc-5458	123	50	(	(	PUNCT
dpc-5458	123	51	2.7	2.7	NUM
dpc-5458	123	52	%	%	NOUN
dpc-5458	123	53	)	)	PUNCT
dpc-5458	123	54	8	8	NUM
dpc-5458	123	55	weeks	week	NOUN
dpc-5458	123	56	6	6	NUM
dpc-5458	123	57	(	(	PUNCT
dpc-5458	123	58	4.1	4.1	NUM
dpc-5458	123	59	%	%	NOUN
dpc-5458	123	60	)	)	PUNCT
dpc-5458	123	61	12	12	NUM
dpc-5458	123	62	weeks	week	NOUN
dpc-5458	123	63	20	20	NUM
dpc-5458	123	64	(	(	PUNCT
dpc-5458	123	65	13.5	13.5	NUM
dpc-5458	123	66	%	%	NOUN
dpc-5458	123	67	)	)	PUNCT
dpc-5458	123	68	24	24	NUM
dpc-5458	123	69	weeks	week	NOUN
dpc-5458	123	70	37	37	NUM
dpc-5458	123	71	(	(	PUNCT
dpc-5458	123	72	25.0	25.0	NUM
dpc-5458	123	73	%	%	NOUN
dpc-5458	123	74	)	)	PUNCT
dpc-5458	123	75	48	48	NUM
dpc-5458	123	76	weeks	week	NOUN
dpc-5458	123	77	54	54	NUM
dpc-5458	123	78	(	(	PUNCT
dpc-5458	123	79	36.5	36.5	NUM
dpc-5458	123	80	%	%	NOUN
dpc-5458	123	81	)	)	PUNCT
dpc-5458	123	82	abbreviations	abbreviation	NOUN
dpc-5458	123	83	:	:	PUNCT
dpc-5458	123	84	pasi	pasi	NOUN
dpc-5458	123	85	:	:	PUNCT
dpc-5458	123	86	psoriasis	psoriasis	NOUN
dpc-5458	123	87	area	area	NOUN
dpc-5458	123	88	severity	severity	PROPN
dpc-5458	123	89	index	index	NOUN
dpc-5458	123	90	.	.	PUNCT
dpc-5458	124	1	figure	figure	NOUN
dpc-5458	124	2	2	2	NUM
dpc-5458	124	3	.	.	PUNCT
dpc-5458	125	1	percentages	percentage	NOUN
dpc-5458	125	2	of	of	ADP
dpc-5458	125	3	patients	patient	NOUN
dpc-5458	125	4	achieving	achieve	VERB
dpc-5458	125	5	pasi	pasi	NOUN
dpc-5458	125	6	50	50	NUM
dpc-5458	125	7	and	and	CCONJ
dpc-5458	125	8	pasi	pasi	NOUN
dpc-5458	125	9	75	75	NUM
dpc-5458	125	10	analyzed	analyze	VERB
dpc-5458	125	11	using	use	VERB
dpc-5458	125	12	the	the	DET
dpc-5458	125	13	last	last	ADJ
dpc-5458	125	14	observation	observation	NOUN
dpc-5458	125	15	carried	carry	VERB
dpc-5458	125	16	forward	forward	ADV
dpc-5458	125	17	analysis	analysis	NOUN
dpc-5458	125	18	(	(	PUNCT
dpc-5458	125	19	locf	locf	PROPN
dpc-5458	125	20	)	)	PUNCT
dpc-5458	125	21	.	.	PUNCT
dpc-5458	126	1	the	the	DET
dpc-5458	126	2	figure	figure	NOUN
dpc-5458	126	3	shows	show	VERB
dpc-5458	126	4	the	the	DET
dpc-5458	126	5	percentages	percentage	NOUN
dpc-5458	126	6	of	of	ADP
dpc-5458	126	7	patients	patient	NOUN
dpc-5458	126	8	achieving	achieve	VERB
dpc-5458	126	9	pasi	pasi	NOUN
dpc-5458	126	10	50	50	NUM
dpc-5458	126	11	or	or	CCONJ
dpc-5458	126	12	pasi	pasi	NOUN
dpc-5458	126	13	75	75	NUM
dpc-5458	126	14	at	at	ADP
dpc-5458	126	15	different	different	ADJ
dpc-5458	126	16	time	time	NOUN
dpc-5458	126	17	points	point	NOUN
dpc-5458	126	18	during	during	ADP
dpc-5458	126	19	dimethyl	dimethyl	NOUN
dpc-5458	126	20	fumarate	fumarate	ADJ
dpc-5458	126	21	treatment	treatment	NOUN
dpc-5458	126	22	.	.	PUNCT
dpc-5458	127	1	this	this	PRON
dpc-5458	127	2	,	,	PUNCT
dpc-5458	127	3	in	in	ADP
dpc-5458	127	4	patients	patient	NOUN
dpc-5458	127	5	who	who	PRON
dpc-5458	127	6	endured	endure	VERB
dpc-5458	127	7	dmf	dmf	PROPN
dpc-5458	127	8	,	,	PUNCT
dpc-5458	127	9	the	the	DET
dpc-5458	127	10	drug	drug	NOUN
dpc-5458	127	11	exerted	exert	VERB
dpc-5458	127	12	remarkable	remarkable	ADJ
dpc-5458	127	13	and	and	CCONJ
dpc-5458	127	14	prolonged	prolonged	ADJ
dpc-5458	127	15	efficacy	efficacy	NOUN
dpc-5458	127	16	in	in	ADP
dpc-5458	127	17	suppressing	suppress	VERB
dpc-5458	127	18	disease	disease	NOUN
dpc-5458	127	19	activity	activity	NOUN
dpc-5458	127	20	,	,	PUNCT
dpc-5458	127	21	especially	especially	ADV
dpc-5458	127	22	in	in	ADP
dpc-5458	127	23	patients	patient	NOUN
dpc-5458	127	24	with	with	ADP
dpc-5458	127	25	a	a	DET
dpc-5458	127	26	disease	disease	NOUN
dpc-5458	127	27	duration	duration	NOUN
dpc-5458	127	28	of	of	ADP
dpc-5458	127	29	less	less	ADJ
dpc-5458	127	30	than	than	ADP
dpc-5458	127	31	five	five	NUM
dpc-5458	127	32	years	year	NOUN
dpc-5458	127	33	.	.	PUNCT
dpc-5458	128	1	comorbidities	comorbiditie	NOUN
dpc-5458	128	2	,	,	PUNCT
dpc-5458	128	3	bmi	bmi	NOUN
dpc-5458	128	4	,	,	PUNCT
dpc-5458	128	5	or	or	CCONJ
dpc-5458	128	6	dose	dose	VERB
dpc-5458	128	7	variations	variation	NOUN
dpc-5458	128	8	within	within	ADP
dpc-5458	128	9	the	the	DET
dpc-5458	128	10	studied	studied	ADJ
dpc-5458	128	11	range	range	NOUN
dpc-5458	128	12	did	do	AUX
dpc-5458	128	13	not	not	PART
dpc-5458	128	14	significantly	significantly	ADV
dpc-5458	128	15	impact	impact	VERB
dpc-5458	128	16	treatment	treatment	NOUN
dpc-5458	128	17	success	success	NOUN
dpc-5458	128	18	,	,	PUNCT
dpc-5458	128	19	underscoring	underscore	VERB
dpc-5458	128	20	the	the	DET
dpc-5458	128	21	utility	utility	NOUN
dpc-5458	128	22	of	of	ADP
dpc-5458	128	23	dmf	dmf	PROPN
dpc-5458	128	24	in	in	ADP
dpc-5458	128	25	diverse	diverse	ADJ
dpc-5458	128	26	patient	patient	ADJ
dpc-5458	128	27	populations	population	NOUN
dpc-5458	128	28	.	.	PUNCT
dpc-5458	129	1	furthermore	furthermore	ADV
dpc-5458	129	2	,	,	PUNCT
dpc-5458	129	3	the	the	DET
dpc-5458	129	4	analysis	analysis	NOUN
dpc-5458	129	5	showed	show	VERB
dpc-5458	129	6	that	that	SCONJ
dpc-5458	129	7	the	the	DET
dpc-5458	129	8	frequency	frequency	NOUN
dpc-5458	129	9	of	of	ADP
dpc-5458	129	10	dmf	dmf	PROPN
dpc-5458	129	11	-	-	ADJ
dpc-5458	129	12	induced	induce	VERB
dpc-5458	129	13	adverse	adverse	ADJ
dpc-5458	129	14	events	event	NOUN
dpc-5458	129	15	was	be	AUX
dpc-5458	129	16	higher	high	ADJ
dpc-5458	129	17	in	in	ADP
dpc-5458	129	18	patients	patient	NOUN
dpc-5458	129	19	with	with	ADP
dpc-5458	129	20	a	a	DET
dpc-5458	129	21	longer	long	ADJ
dpc-5458	129	22	history	history	NOUN
dpc-5458	129	23	of	of	ADP
dpc-5458	129	24	psoriasis	psoriasis	NOUN
dpc-5458	129	25	.	.	PUNCT
dpc-5458	130	1	this	this	DET
dpc-5458	130	2	observation	observation	NOUN
dpc-5458	130	3	supports	support	VERB
dpc-5458	130	4	the	the	DET
dpc-5458	130	5	postulation	postulation	NOUN
dpc-5458	130	6	that	that	SCONJ
dpc-5458	130	7	dmf	dmf	PROPN
dpc-5458	130	8	represents	represent	VERB
dpc-5458	130	9	a	a	DET
dpc-5458	130	10	useful	useful	ADJ
dpc-5458	130	11	first	first	ADJ
dpc-5458	130	12	-	-	PUNCT
dpc-5458	130	13	line	line	NOUN
dpc-5458	130	14	therapy	therapy	NOUN
dpc-5458	130	15	option	option	NOUN
dpc-5458	130	16	.	.	PUNCT
dpc-5458	131	1	moreover	moreover	ADV
dpc-5458	131	2	,	,	PUNCT
dpc-5458	131	3	since	since	SCONJ
dpc-5458	131	4	the	the	DET
dpc-5458	131	5	adverse	adverse	ADJ
dpc-5458	131	6	events	event	NOUN
dpc-5458	131	7	leading	lead	VERB
dpc-5458	131	8	to	to	ADP
dpc-5458	131	9	treatment	treatment	NOUN
dpc-5458	131	10	discontinuation	discontinuation	NOUN
dpc-5458	131	11	mainly	mainly	ADV
dpc-5458	131	12	occurred	occur	VERB
dpc-5458	131	13	during	during	ADP
dpc-5458	131	14	the	the	DET
dpc-5458	131	15	first	first	ADJ
dpc-5458	131	16	12	12	NUM
dpc-5458	131	17	weeks	week	NOUN
dpc-5458	131	18	,	,	PUNCT
dpc-5458	131	19	patients	patient	NOUN
dpc-5458	131	20	could	could	AUX
dpc-5458	131	21	be	be	AUX
dpc-5458	131	22	promptly	promptly	ADV
dpc-5458	131	23	switched	switch	VERB
dpc-5458	131	24	to	to	ADP
dpc-5458	131	25	other	other	ADJ
dpc-5458	131	26	therapies	therapy	NOUN
dpc-5458	131	27	if	if	SCONJ
dpc-5458	131	28	dmf	dmf	PROPN
dpc-5458	131	29	was	be	AUX
dpc-5458	131	30	not	not	PART
dpc-5458	131	31	well	well	ADV
dpc-5458	131	32	tolerated	tolerate	VERB
dpc-5458	131	33	.	.	PUNCT
dpc-5458	132	1	physicians	physician	NOUN
dpc-5458	132	2	should	should	AUX
dpc-5458	132	3	inform	inform	VERB
dpc-5458	132	4	patients	patient	NOUN
dpc-5458	132	5	about	about	ADP
dpc-5458	132	6	the	the	DET
dpc-5458	132	7	frequency	frequency	NOUN
dpc-5458	132	8	and	and	CCONJ
dpc-5458	132	9	types	type	NOUN
dpc-5458	132	10	of	of	ADP
dpc-5458	132	11	adverse	adverse	ADJ
dpc-5458	132	12	events	event	NOUN
dpc-5458	132	13	as	as	ADV
dpc-5458	132	14	well	well	ADV
dpc-5458	132	15	as	as	ADP
dpc-5458	132	16	of	of	ADP
dpc-5458	132	17	the	the	DET
dpc-5458	132	18	possibility	possibility	NOUN
dpc-5458	132	19	of	of	ADP
dpc-5458	132	20	slowly	slowly	ADV
dpc-5458	132	21	titrating	titrate	VERB
dpc-5458	132	22	the	the	DET
dpc-5458	132	23	dosage	dosage	NOUN
dpc-5458	132	24	to	to	PART
dpc-5458	132	25	minimize	minimize	VERB
dpc-5458	132	26	them	they	PRON
dpc-5458	132	27	.	.	PUNCT
dpc-5458	133	1	it	it	PRON
dpc-5458	133	2	is	be	AUX
dpc-5458	133	3	crucial	crucial	ADJ
dpc-5458	133	4	that	that	SCONJ
dpc-5458	133	5	physicians	physician	NOUN
dpc-5458	133	6	explain	explain	VERB
dpc-5458	133	7	to	to	ADP
dpc-5458	133	8	patients	patient	NOUN
dpc-5458	133	9	that	that	SCONJ
dpc-5458	133	10	dmf	dmf	PROPN
dpc-5458	133	11	requires	require	VERB
dpc-5458	133	12	time	time	NOUN
dpc-5458	133	13	to	to	PART
dpc-5458	133	14	exert	exert	VERB
dpc-5458	133	15	its	its	PRON
dpc-5458	133	16	clinical	clinical	ADJ
dpc-5458	133	17	effects	effect	NOUN
dpc-5458	133	18	and	and	CCONJ
dpc-5458	133	19	that	that	SCONJ
dpc-5458	133	20	most	most	ADJ
dpc-5458	133	21	adverse	adverse	ADJ
dpc-5458	133	22	events	event	NOUN
dpc-5458	133	23	are	be	AUX
dpc-5458	133	24	manageable	manageable	ADJ
dpc-5458	133	25	or	or	CCONJ
dpc-5458	133	26	transient	transient	ADJ
dpc-5458	133	27	.	.	PUNCT
dpc-5458	134	1	this	this	DET
dpc-5458	134	2	proactive	proactive	ADJ
dpc-5458	134	3	approach	approach	NOUN
dpc-5458	134	4	can	can	AUX
dpc-5458	134	5	help	help	AUX
dpc-5458	134	6	identify	identify	VERB
dpc-5458	134	7	patients	patient	NOUN
dpc-5458	134	8	most	most	ADV
dpc-5458	134	9	likely	likely	ADJ
dpc-5458	134	10	to	to	PART
dpc-5458	134	11	tolerate	tolerate	VERB
dpc-5458	134	12	and	and	CCONJ
dpc-5458	134	13	benefit	benefit	VERB
dpc-5458	134	14	from	from	ADP
dpc-5458	134	15	long	long	ADJ
dpc-5458	134	16	-	-	PUNCT
dpc-5458	134	17	term	term	NOUN
dpc-5458	134	18	dmf	dmf	PROPN
dpc-5458	134	19	therapy	therapy	NOUN
dpc-5458	134	20	[	[	X
dpc-5458	134	21	26	26	NUM
dpc-5458	134	22	]	]	PUNCT
dpc-5458	134	23	.	.	PUNCT
dpc-5458	135	1	additionally	additionally	ADV
dpc-5458	135	2	,	,	PUNCT
dpc-5458	135	3	our	our	PRON
dpc-5458	135	4	real	real	ADJ
dpc-5458	135	5	-	-	PUNCT
dpc-5458	135	6	life	life	NOUN
dpc-5458	135	7	study	study	NOUN
dpc-5458	135	8	revealed	reveal	VERB
dpc-5458	135	9	that	that	SCONJ
dpc-5458	135	10	dmf	dmf	PROPN
dpc-5458	135	11	is	be	AUX
dpc-5458	135	12	predominantly	predominantly	ADV
dpc-5458	135	13	prescribed	prescribe	VERB
dpc-5458	135	14	for	for	ADP
dpc-5458	135	15	moderate	moderate	ADJ
dpc-5458	135	16	psoriasis	psoriasis	NOUN
dpc-5458	135	17	.	.	PUNCT
dpc-5458	136	1	this	this	DET
dpc-5458	136	2	pattern	pattern	NOUN
dpc-5458	136	3	of	of	ADP
dpc-5458	136	4	use	use	NOUN
dpc-5458	136	5	aligns	align	VERB
dpc-5458	136	6	with	with	ADP
dpc-5458	136	7	dmf	dmf	PROPN
dpc-5458	136	8	’s	’s	PART
dpc-5458	136	9	favorable	favorable	ADJ
dpc-5458	136	10	safety	safety	NOUN
dpc-5458	136	11	and	and	CCONJ
dpc-5458	136	12	tolerability	tolerability	NOUN
dpc-5458	136	13	profile	profile	NOUN
dpc-5458	136	14	and	and	CCONJ
dpc-5458	136	15	with	with	ADP
dpc-5458	136	16	the	the	DET
dpc-5458	136	17	need	need	NOUN
dpc-5458	136	18	for	for	ADP
dpc-5458	136	19	long	long	ADJ
dpc-5458	136	20	-	-	PUNCT
dpc-5458	136	21	term	term	NOUN
dpc-5458	136	22	disease	disease	NOUN
dpc-5458	136	23	control	control	NOUN
dpc-5458	136	24	in	in	ADP
dpc-5458	136	25	patients	patient	NOUN
dpc-5458	136	26	not	not	PART
dpc-5458	136	27	requiring	require	VERB
dpc-5458	136	28	or	or	CCONJ
dpc-5458	136	29	not	not	PART
dpc-5458	136	30	eligible	eligible	ADJ
dpc-5458	136	31	for	for	ADP
dpc-5458	136	32	biologics	biologic	NOUN
dpc-5458	136	33	.	.	PUNCT
dpc-5458	137	1	compared	compare	VERB
dpc-5458	137	2	to	to	ADP
dpc-5458	137	3	mtx	mtx	NOUN
dpc-5458	137	4	,	,	PUNCT
dpc-5458	137	5	cyclosporin	cyclosporin	NOUN
dpc-5458	137	6	,	,	PUNCT
dpc-5458	137	7	and	and	CCONJ
dpc-5458	137	8	acitretin	acitretin	PROPN
dpc-5458	137	9	,	,	PUNCT
dpc-5458	137	10	dmf	dmf	PROPN
dpc-5458	137	11	offers	offer	VERB
dpc-5458	137	12	a	a	DET
dpc-5458	137	13	favorable	favorable	ADJ
dpc-5458	137	14	safety	safety	NOUN
dpc-5458	137	15	profile	profile	NOUN
dpc-5458	137	16	.	.	PUNCT
dpc-5458	138	1	mtx	mtx	NOUN
dpc-5458	138	2	is	be	AUX
dpc-5458	138	3	effective	effective	ADJ
dpc-5458	138	4	in	in	ADP
dpc-5458	138	5	chronic	chronic	ADJ
dpc-5458	138	6	plaque	plaque	NOUN
dpc-5458	138	7	psoriasis	psoriasis	NOUN
dpc-5458	138	8	and	and	CCONJ
dpc-5458	138	9	psoriatic	psoriatic	ADJ
dpc-5458	138	10	arthritis	arthritis	NOUN
dpc-5458	138	11	but	but	CCONJ
dpc-5458	138	12	requires	require	VERB
dpc-5458	138	13	regular	regular	ADJ
dpc-5458	138	14	monitoring	monitoring	NOUN
dpc-5458	138	15	due	due	ADP
dpc-5458	138	16	to	to	ADP
dpc-5458	138	17	risks	risk	NOUN
dpc-5458	138	18	of	of	ADP
dpc-5458	138	19	hepatotoxicity	hepatotoxicity	NOUN
dpc-5458	138	20	and	and	CCONJ
dpc-5458	138	21	myelosuppression	myelosuppression	NOUN
dpc-5458	138	22	[	[	X
dpc-5458	138	23	2,27,28	2,27,28	NUM
dpc-5458	138	24	]	]	PUNCT
dpc-5458	138	25	.	.	PUNCT
dpc-5458	139	1	cyclosporin	cyclosporin	NOUN
dpc-5458	139	2	acts	act	VERB
dpc-5458	139	3	rapidly	rapidly	ADV
dpc-5458	139	4	and	and	CCONJ
dpc-5458	139	5	is	be	AUX
dpc-5458	139	6	suitable	suitable	ADJ
dpc-5458	139	7	for	for	ADP
dpc-5458	139	8	severe	severe	ADJ
dpc-5458	139	9	or	or	CCONJ
dpc-5458	139	10	non	non	ADJ
dpc-5458	139	11	-	-	ADJ
dpc-5458	139	12	plaque	plaque	ADJ
dpc-5458	139	13	forms	form	NOUN
dpc-5458	139	14	but	but	CCONJ
dpc-5458	139	15	is	be	AUX
dpc-5458	139	16	limited	limit	VERB
dpc-5458	139	17	by	by	ADP
dpc-5458	139	18	nephrotoxicity	nephrotoxicity	NOUN
dpc-5458	139	19	and	and	CCONJ
dpc-5458	139	20	metabolic	metabolic	NOUN
dpc-5458	139	21	effects	effect	NOUN
dpc-5458	139	22	and	and	CCONJ
dpc-5458	139	23	is	be	AUX
dpc-5458	139	24	recommended	recommend	VERB
dpc-5458	139	25	for	for	ADP
dpc-5458	139	26	intermittent	intermittent	ADJ
dpc-5458	139	27	use	use	NOUN
dpc-5458	139	28	for	for	ADP
dpc-5458	139	29	up	up	ADP
dpc-5458	139	30	to	to	PART
dpc-5458	139	31	one	one	NUM
dpc-5458	139	32	year	year	NOUN
dpc-5458	139	33	[	[	X
dpc-5458	139	34	29	29	NUM
dpc-5458	139	35	]	]	PUNCT
dpc-5458	139	36	.	.	PUNCT
dpc-5458	140	1	acitretin	acitretin	PROPN
dpc-5458	140	2	is	be	AUX
dpc-5458	140	3	more	more	ADV
dpc-5458	140	4	effective	effective	ADJ
dpc-5458	140	5	in	in	ADP
dpc-5458	140	6	palmoplantar	palmoplantar	NOUN
dpc-5458	140	7	and	and	CCONJ
dpc-5458	140	8	hyperkeratotic	hyperkeratotic	ADJ
dpc-5458	140	9	psoriasis	psoriasis	NOUN
dpc-5458	140	10	and	and	CCONJ
dpc-5458	140	11	safe	safe	ADJ
dpc-5458	140	12	for	for	ADP
dpc-5458	140	13	patients	patient	NOUN
dpc-5458	140	14	with	with	ADP
dpc-5458	140	15	a	a	DET
dpc-5458	140	16	history	history	NOUN
dpc-5458	140	17	of	of	ADP
dpc-5458	140	18	malignancy	malignancy	NOUN
dpc-5458	140	19	due	due	ADP
dpc-5458	140	20	to	to	ADP
dpc-5458	140	21	its	its	PRON
dpc-5458	140	22	non	non	ADJ
dpc-5458	140	23	immunosuppressive	immunosuppressive	ADJ
dpc-5458	140	24	profile	profile	NOUN
dpc-5458	140	25	,	,	PUNCT
dpc-5458	140	26	but	but	CCONJ
dpc-5458	140	27	its	its	PRON
dpc-5458	140	28	use	use	NOUN
dpc-5458	140	29	is	be	AUX
dpc-5458	140	30	limited	limit	VERB
dpc-5458	140	31	by	by	ADP
dpc-5458	140	32	mucocutaneous	mucocutaneous	ADJ
dpc-5458	140	33	side	side	NOUN
dpc-5458	140	34	effects	effect	NOUN
dpc-5458	140	35	,	,	PUNCT
dpc-5458	140	36	teratogenicity	teratogenicity	NOUN
dpc-5458	140	37	,	,	PUNCT
dpc-5458	140	38	and	and	CCONJ
dpc-5458	140	39	potential	potential	ADJ
dpc-5458	140	40	hepatotoxicity	hepatotoxicity	NOUN
dpc-5458	140	41	original	original	ADJ
dpc-5458	140	42	article	article	NOUN
dpc-5458	140	43	|	|	ADV
dpc-5458	140	44	dermatol	dermatol	ADJ
dpc-5458	140	45	pract	pract	NOUN
dpc-5458	140	46	concept	concept	NOUN
dpc-5458	140	47	.	.	PUNCT
dpc-5458	141	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	141	2	7	7	NUM
dpc-5458	141	3	table	table	NOUN
dpc-5458	141	4	4	4	NUM
dpc-5458	141	5	.	.	PUNCT
dpc-5458	141	6	mean	mean	ADJ
dpc-5458	141	7	pasi	pasi	NOUN
dpc-5458	141	8	and	and	CCONJ
dpc-5458	141	9	percentages	percentage	NOUN
dpc-5458	141	10	of	of	ADP
dpc-5458	141	11	patients	patient	NOUN
dpc-5458	141	12	achieving	achieve	VERB
dpc-5458	141	13	pasi	pasi	NOUN
dpc-5458	141	14	50	50	NUM
dpc-5458	141	15	and	and	CCONJ
dpc-5458	141	16	pasi	pasi	NOUN
dpc-5458	141	17	75	75	NUM
dpc-5458	141	18	by	by	ADP
dpc-5458	141	19	visit	visit	NOUN
dpc-5458	141	20	and	and	CCONJ
dpc-5458	141	21	naïve	naïve	ADJ
dpc-5458	141	22	status	status	NOUN
dpc-5458	141	23	analyzed	analyze	VERB
dpc-5458	141	24	using	use	VERB
dpc-5458	141	25	the	the	DET
dpc-5458	141	26	last	last	ADJ
dpc-5458	141	27	observation	observation	NOUN
dpc-5458	141	28	carried	carry	VERB
dpc-5458	141	29	forward	forward	ADV
dpc-5458	141	30	analysis	analysis	NOUN
dpc-5458	141	31	(	(	PUNCT
dpc-5458	141	32	locf	locf	PROPN
dpc-5458	141	33	)	)	PUNCT
dpc-5458	141	34	.	.	PUNCT
dpc-5458	142	1	visit	visit	NOUN
dpc-5458	142	2	mean	mean	NOUN
dpc-5458	142	3	pasi	pasi	NOUN
dpc-5458	142	4	(	(	PUNCT
dpc-5458	142	5	naïve	naïve	ADJ
dpc-5458	142	6	)	)	PUNCT
dpc-5458	142	7	mean	mean	NOUN
dpc-5458	142	8	pasi	pasi	NOUN
dpc-5458	142	9	(	(	PUNCT
dpc-5458	142	10	exp	exp	NOUN
dpc-5458	142	11	)	)	PUNCT
dpc-5458	142	12	p	p	NOUN
dpc-5458	142	13	-	-	PUNCT
dpc-5458	142	14	value	value	NOUN
dpc-5458	142	15	(	(	PUNCT
dpc-5458	142	16	pasi	pasi	NOUN
dpc-5458	142	17	)	)	PUNCT
dpc-5458	142	18	pasi	pasi	NOUN
dpc-5458	142	19	50	50	NUM
dpc-5458	142	20	(	(	PUNCT
dpc-5458	142	21	%	%	INTJ
dpc-5458	142	22	)	)	PUNCT
dpc-5458	142	23	naïve	naïve	ADJ
dpc-5458	142	24	pasi	pasi	NOUN
dpc-5458	142	25	50	50	NUM
dpc-5458	142	26	(	(	PUNCT
dpc-5458	142	27	%	%	NOUN
dpc-5458	142	28	)	)	PUNCT
dpc-5458	142	29	exp	exp	NOUN
dpc-5458	142	30	p	p	NOUN
dpc-5458	142	31	-	-	PUNCT
dpc-5458	142	32	value	value	NOUN
dpc-5458	142	33	(	(	PUNCT
dpc-5458	142	34	pasi	pasi	NOUN
dpc-5458	142	35	50	50	NUM
dpc-5458	142	36	)	)	PUNCT
dpc-5458	142	37	pasi	pasi	NOUN
dpc-5458	142	38	75	75	NUM
dpc-5458	142	39	(	(	PUNCT
dpc-5458	142	40	%	%	INTJ
dpc-5458	142	41	)	)	PUNCT
dpc-5458	142	42	naïve	naïve	ADJ
dpc-5458	142	43	pasi	pasi	NOUN
dpc-5458	142	44	75	75	NUM
dpc-5458	142	45	(	(	PUNCT
dpc-5458	142	46	%	%	INTJ
dpc-5458	142	47	)	)	PUNCT
dpc-5458	142	48	exp	exp	NOUN
dpc-5458	142	49	p	p	NOUN
dpc-5458	142	50	-	-	PUNCT
dpc-5458	142	51	value	value	NOUN
dpc-5458	142	52	(	(	PUNCT
dpc-5458	142	53	pasi	pasi	NOUN
dpc-5458	142	54	75	75	NUM
dpc-5458	142	55	)	)	PUNCT
dpc-5458	142	56	baseline	baseline	VERB
dpc-5458	142	57	8.6	8.6	NUM
dpc-5458	142	58	(	(	PUNCT
dpc-5458	142	59	±3.9	±3.9	PROPN
dpc-5458	142	60	)	)	PUNCT
dpc-5458	142	61	9.5	9.5	NUM
dpc-5458	142	62	(	(	PUNCT
dpc-5458	142	63	±4.6	±4.6	NOUN
dpc-5458	142	64	)	)	PUNCT
dpc-5458	142	65	0.190	0.190	NUM
dpc-5458	142	66	–	–	PUNCT
dpc-5458	142	67	–	–	PUNCT
dpc-5458	142	68	–	–	PUNCT
dpc-5458	142	69	–	–	PUNCT
dpc-5458	142	70	–	–	PUNCT
dpc-5458	142	71	–	–	PUNCT
dpc-5458	142	72	4	4	NUM
dpc-5458	142	73	weeks	week	NOUN
dpc-5458	142	74	7.3	7.3	NUM
dpc-5458	142	75	(	(	PUNCT
dpc-5458	142	76	±3.9	±3.9	PROPN
dpc-5458	142	77	)	)	PUNCT
dpc-5458	142	78	8.1	8.1	NUM
dpc-5458	142	79	(	(	PUNCT
dpc-5458	142	80	±4.5	±4.5	PROPN
dpc-5458	142	81	)	)	PUNCT
dpc-5458	142	82	0.228	0.228	NUM
dpc-5458	142	83	6.7	6.7	NUM
dpc-5458	142	84	%	%	NOUN
dpc-5458	142	85	(	(	PUNCT
dpc-5458	142	86	6/89	6/89	NUM
dpc-5458	142	87	)	)	PUNCT
dpc-5458	142	88	5.8	5.8	NUM
dpc-5458	142	89	%	%	NOUN
dpc-5458	142	90	(	(	PUNCT
dpc-5458	142	91	3/52	3/52	NUM
dpc-5458	142	92	)	)	PUNCT
dpc-5458	142	93	0.820	0.820	NUM
dpc-5458	142	94	3.4	3.4	NUM
dpc-5458	142	95	%	%	NOUN
dpc-5458	142	96	(	(	PUNCT
dpc-5458	142	97	3/89	3/89	NUM
dpc-5458	142	98	)	)	PUNCT
dpc-5458	142	99	1.9	1.9	NUM
dpc-5458	142	100	%	%	NOUN
dpc-5458	142	101	(	(	PUNCT
dpc-5458	142	102	1/52	1/52	NUM
dpc-5458	142	103	)	)	PUNCT
dpc-5458	142	104	0.619	0.619	NUM
dpc-5458	142	105	8	8	NUM
dpc-5458	142	106	weeks	week	NOUN
dpc-5458	142	107	6.6	6.6	NUM
dpc-5458	142	108	(	(	PUNCT
dpc-5458	142	109	±3.8	±3.8	NOUN
dpc-5458	142	110	)	)	PUNCT
dpc-5458	142	111	7.4	7.4	NUM
dpc-5458	142	112	(	(	PUNCT
dpc-5458	142	113	±4.5	±4.5	PROPN
dpc-5458	142	114	)	)	PUNCT
dpc-5458	142	115	0.273	0.273	NUM
dpc-5458	142	116	16.3	16.3	NUM
dpc-5458	142	117	%	%	NOUN
dpc-5458	142	118	(	(	PUNCT
dpc-5458	142	119	8/49	8/49	NUM
dpc-5458	142	120	)	)	PUNCT
dpc-5458	142	121	9.1	9.1	NUM
dpc-5458	142	122	%	%	NOUN
dpc-5458	142	123	(	(	PUNCT
dpc-5458	142	124	3/33	3/33	NUM
dpc-5458	142	125	)	)	PUNCT
dpc-5458	142	126	0.103	0.103	NUM
dpc-5458	142	127	8.2	8.2	NUM
dpc-5458	142	128	%	%	NOUN
dpc-5458	142	129	(	(	PUNCT
dpc-5458	142	130	4/49	4/49	NUM
dpc-5458	142	131	)	)	PUNCT
dpc-5458	142	132	3.0	3.0	NUM
dpc-5458	142	133	%	%	NOUN
dpc-5458	142	134	(	(	PUNCT
dpc-5458	142	135	1/33	1/33	NUM
dpc-5458	142	136	)	)	PUNCT
dpc-5458	142	137	0.344	0.344	NUM
dpc-5458	142	138	12	12	NUM
dpc-5458	142	139	weeks	week	NOUN
dpc-5458	142	140	5.4	5.4	NUM
dpc-5458	142	141	(	(	PUNCT
dpc-5458	142	142	±4.0	±4.0	PROPN
dpc-5458	142	143	)	)	PUNCT
dpc-5458	142	144	6.2	6.2	NUM
dpc-5458	142	145	(	(	PUNCT
dpc-5458	142	146	±4.4	±4.4	NOUN
dpc-5458	142	147	)	)	PUNCT
dpc-5458	142	148	0.220	0.220	NOUN
dpc-5458	142	149	41.9	41.9	NUM
dpc-5458	142	150	%	%	NOUN
dpc-5458	142	151	(	(	PUNCT
dpc-5458	142	152	26/62	26/62	NUM
dpc-5458	142	153	)	)	PUNCT
dpc-5458	142	154	43.6	43.6	NUM
dpc-5458	142	155	%	%	NOUN
dpc-5458	142	156	(	(	PUNCT
dpc-5458	142	157	17/39	17/39	NOUN
dpc-5458	142	158	)	)	PUNCT
dpc-5458	142	159	0.871	0.871	NUM
dpc-5458	142	160	22.6	22.6	NUM
dpc-5458	142	161	%	%	NOUN
dpc-5458	142	162	(	(	PUNCT
dpc-5458	142	163	14/62	14/62	NUM
dpc-5458	142	164	)	)	PUNCT
dpc-5458	142	165	12.8	12.8	NUM
dpc-5458	142	166	%	%	NOUN
dpc-5458	142	167	(	(	PUNCT
dpc-5458	142	168	5/39	5/39	NUM
dpc-5458	142	169	)	)	PUNCT
dpc-5458	142	170	0.224	0.224	NUM
dpc-5458	142	171	24	24	NUM
dpc-5458	142	172	weeks	week	NOUN
dpc-5458	142	173	4.4	4.4	NUM
dpc-5458	142	174	(	(	PUNCT
dpc-5458	142	175	±4.1	±4.1	PROPN
dpc-5458	142	176	)	)	PUNCT
dpc-5458	142	177	5.4	5.4	NUM
dpc-5458	142	178	(	(	PUNCT
dpc-5458	142	179	±5.4	±5.4	PROPN
dpc-5458	142	180	)	)	PUNCT
dpc-5458	142	181	0.209	0.209	NUM
dpc-5458	142	182	76.9	76.9	NUM
dpc-5458	142	183	%	%	NOUN
dpc-5458	142	184	(	(	PUNCT
dpc-5458	142	185	40/52	40/52	NUM
dpc-5458	142	186	)	)	PUNCT
dpc-5458	142	187	77.1	77.1	NUM
dpc-5458	142	188	%	%	NOUN
dpc-5458	142	189	(	(	PUNCT
dpc-5458	142	190	27/35	27/35	NUM
dpc-5458	142	191	)	)	PUNCT
dpc-5458	142	192	0.981	0.981	NUM
dpc-5458	142	193	42.3	42.3	NUM
dpc-5458	142	194	%	%	NOUN
dpc-5458	142	195	(	(	PUNCT
dpc-5458	142	196	22/52	22/52	NUM
dpc-5458	142	197	)	)	PUNCT
dpc-5458	142	198	34.3	34.3	NUM
dpc-5458	142	199	%	%	NOUN
dpc-5458	142	200	(	(	PUNCT
dpc-5458	142	201	12/35	12/35	NUM
dpc-5458	142	202	)	)	PUNCT
dpc-5458	142	203	0.455	0.455	NUM
dpc-5458	142	204	48	48	NUM
dpc-5458	142	205	weeks	week	NOUN
dpc-5458	142	206	4.0	4.0	NUM
dpc-5458	142	207	(	(	PUNCT
dpc-5458	142	208	±4.1	±4.1	PROPN
dpc-5458	142	209	)	)	PUNCT
dpc-5458	142	210	4.7	4.7	NUM
dpc-5458	142	211	(	(	PUNCT
dpc-5458	142	212	±5.6	±5.6	PROPN
dpc-5458	142	213	)	)	PUNCT
dpc-5458	142	214	0.372	0.372	NUM
dpc-5458	142	215	93.9	93.9	NUM
dpc-5458	142	216	%	%	NOUN
dpc-5458	142	217	(	(	PUNCT
dpc-5458	142	218	31/33	31/33	NUM
dpc-5458	142	219	)	)	PUNCT
dpc-5458	142	220	95.1	95.1	NUM
dpc-5458	142	221	%	%	NOUN
dpc-5458	142	222	(	(	PUNCT
dpc-5458	142	223	20/21	20/21	NUM
dpc-5458	142	224	)	)	PUNCT
dpc-5458	142	225	0.841	0.841	NUM
dpc-5458	142	226	66.7	66.7	NUM
dpc-5458	142	227	%	%	NOUN
dpc-5458	142	228	(	(	PUNCT
dpc-5458	142	229	22/33	22/33	NUM
dpc-5458	142	230	)	)	PUNCT
dpc-5458	142	231	76.2	76.2	NUM
dpc-5458	142	232	%	%	NOUN
dpc-5458	142	233	(	(	PUNCT
dpc-5458	142	234	16	16	NUM
dpc-5458	142	235	)	)	PUNCT
dpc-5458	142	236	–	–	PUNCT
dpc-5458	142	237	table	table	NOUN
dpc-5458	142	238	5	5	NUM
dpc-5458	142	239	.	.	PUNCT
dpc-5458	143	1	mean	mean	VERB
dpc-5458	143	2	psoriasis	psoriasis	NOUN
dpc-5458	143	3	area	area	NOUN
dpc-5458	143	4	severity	severity	NOUN
dpc-5458	143	5	index	index	NOUN
dpc-5458	143	6	by	by	ADP
dpc-5458	143	7	visit	visit	NOUN
dpc-5458	143	8	and	and	CCONJ
dpc-5458	143	9	disease	disease	NOUN
dpc-5458	143	10	duration	duration	NOUN
dpc-5458	143	11	analyzed	analyze	VERB
dpc-5458	143	12	using	use	VERB
dpc-5458	143	13	the	the	DET
dpc-5458	143	14	last	last	ADJ
dpc-5458	143	15	observation	observation	NOUN
dpc-5458	143	16	carried	carry	VERB
dpc-5458	143	17	forward	forward	ADV
dpc-5458	143	18	analysis	analysis	NOUN
dpc-5458	143	19	(	(	PUNCT
dpc-5458	143	20	locf	locf	PROPN
dpc-5458	143	21	)	)	PUNCT
dpc-5458	143	22	.	.	PUNCT
dpc-5458	144	1	visit	visit	VERB
dpc-5458	144	2	<	<	X
dpc-5458	144	3	5	5	NUM
dpc-5458	144	4	years	year	NOUN
dpc-5458	144	5	(	(	PUNCT
dpc-5458	144	6	n=33	n=33	NOUN
dpc-5458	144	7	)	)	PUNCT
dpc-5458	144	8	5–10	5–10	ADJ
dpc-5458	144	9	years	year	NOUN
dpc-5458	144	10	(	(	PUNCT
dpc-5458	144	11	n=39	n=39	NOUN
dpc-5458	144	12	)	)	PUNCT
dpc-5458	144	13	>	>	SYM
dpc-5458	144	14	10	10	NUM
dpc-5458	144	15	years	year	NOUN
dpc-5458	144	16	(	(	PUNCT
dpc-5458	144	17	n=76	n=76	NOUN
dpc-5458	144	18	)	)	PUNCT
dpc-5458	144	19	p	p	NOUN
dpc-5458	144	20	-	-	PUNCT
dpc-5458	144	21	value	value	NOUN
dpc-5458	144	22	(	(	PUNCT
dpc-5458	144	23	<	<	X
dpc-5458	144	24	5/5–10	5/5–10	NUM
dpc-5458	144	25	/>10	/>10	ADJ
dpc-5458	144	26	years	year	NOUN
dpc-5458	144	27	)	)	PUNCT
dpc-5458	144	28	≤10	≤10	ADJ
dpc-5458	144	29	years	year	NOUN
dpc-5458	144	30	(	(	PUNCT
dpc-5458	144	31	n=72	n=72	NOUN
dpc-5458	144	32	)	)	PUNCT
dpc-5458	144	33	>	>	SYM
dpc-5458	144	34	10	10	NUM
dpc-5458	144	35	years	year	NOUN
dpc-5458	144	36	(	(	PUNCT
dpc-5458	144	37	n=76	n=76	NOUN
dpc-5458	144	38	)	)	PUNCT
dpc-5458	144	39	p	p	NOUN
dpc-5458	144	40	-	-	PUNCT
dpc-5458	144	41	value	value	NOUN
dpc-5458	144	42	(	(	PUNCT
dpc-5458	144	43	≤10	≤10	ADJ
dpc-5458	144	44	vs	vs	ADP
dpc-5458	144	45	>	>	X
dpc-5458	144	46	10	10	NUM
dpc-5458	144	47	years	year	NOUN
dpc-5458	144	48	)	)	PUNCT
dpc-5458	144	49	baseline	baseline	VERB
dpc-5458	144	50	8.5	8.5	NUM
dpc-5458	144	51	(	(	PUNCT
dpc-5458	144	52	±3.7	±3.7	PROPN
dpc-5458	144	53	)	)	PUNCT
dpc-5458	144	54	8.7	8.7	NUM
dpc-5458	144	55	(	(	PUNCT
dpc-5458	144	56	±4.6	±4.6	PROPN
dpc-5458	144	57	)	)	PUNCT
dpc-5458	144	58	9.3	9.3	NUM
dpc-5458	144	59	(	(	PUNCT
dpc-5458	144	60	±4.3	±4.3	NOUN
dpc-5458	144	61	)	)	PUNCT
dpc-5458	144	62	0.611	0.611	NUM
dpc-5458	144	63	8.6	8.6	NUM
dpc-5458	144	64	(	(	PUNCT
dpc-5458	144	65	±4.2	±4.2	NOUN
dpc-5458	144	66	)	)	PUNCT
dpc-5458	144	67	9.3	9.3	NUM
dpc-5458	144	68	(	(	PUNCT
dpc-5458	144	69	±4.3	±4.3	NOUN
dpc-5458	144	70	)	)	PUNCT
dpc-5458	144	71	0.336	0.336	NUM
dpc-5458	144	72	week	week	NOUN
dpc-5458	144	73	4	4	NUM
dpc-5458	144	74	7.0	7.0	NUM
dpc-5458	144	75	(	(	PUNCT
dpc-5458	144	76	±3.5	±3.5	PROPN
dpc-5458	144	77	)	)	PUNCT
dpc-5458	145	1	7.0	7.0	NUM
dpc-5458	145	2	(	(	PUNCT
dpc-5458	145	3	±4.0	±4.0	PROPN
dpc-5458	145	4	)	)	PUNCT
dpc-5458	145	5	8.1	8.1	NUM
dpc-5458	145	6	(	(	PUNCT
dpc-5458	145	7	±4.4	±4.4	NOUN
dpc-5458	145	8	)	)	PUNCT
dpc-5458	145	9	0.314	0.314	NUM
dpc-5458	145	10	7.0	7.0	NUM
dpc-5458	145	11	(	(	PUNCT
dpc-5458	145	12	±3.7	±3.7	NOUN
dpc-5458	145	13	)	)	PUNCT
dpc-5458	145	14	8.1	8.1	NUM
dpc-5458	145	15	(	(	PUNCT
dpc-5458	145	16	±4.4	±4.4	NOUN
dpc-5458	145	17	)	)	PUNCT
dpc-5458	145	18	0.128	0.128	NUM
dpc-5458	145	19	week	week	NOUN
dpc-5458	145	20	8	8	NUM
dpc-5458	145	21	6.2	6.2	NUM
dpc-5458	145	22	(	(	PUNCT
dpc-5458	145	23	±3.3	±3.3	PROPN
dpc-5458	145	24	)	)	PUNCT
dpc-5458	145	25	6.2	6.2	NUM
dpc-5458	145	26	(	(	PUNCT
dpc-5458	145	27	±3.8	±3.8	NOUN
dpc-5458	145	28	)	)	PUNCT
dpc-5458	145	29	7.5	7.5	NUM
dpc-5458	145	30	(	(	PUNCT
dpc-5458	145	31	±4.5	±4.5	PROPN
dpc-5458	145	32	)	)	PUNCT
dpc-5458	145	33	0.150	0.150	NUM
dpc-5458	145	34	6.2	6.2	NUM
dpc-5458	145	35	(	(	PUNCT
dpc-5458	145	36	±3.6	±3.6	PROPN
dpc-5458	145	37	)	)	PUNCT
dpc-5458	145	38	7.5	7.5	NUM
dpc-5458	145	39	(	(	PUNCT
dpc-5458	145	40	±4.5	±4.5	PROPN
dpc-5458	145	41	)	)	PUNCT
dpc-5458	145	42	0.051	0.051	NUM
dpc-5458	145	43	week	week	NOUN
dpc-5458	145	44	12	12	NUM
dpc-5458	145	45	4.7	4.7	NUM
dpc-5458	145	46	(	(	PUNCT
dpc-5458	145	47	±3.6	±3.6	PROPN
dpc-5458	145	48	)	)	PUNCT
dpc-5458	145	49	5.2	5.2	NUM
dpc-5458	145	50	(	(	PUNCT
dpc-5458	145	51	±3.8	±3.8	NOUN
dpc-5458	145	52	)	)	PUNCT
dpc-5458	145	53	6.4	6.4	NUM
dpc-5458	145	54	(	(	PUNCT
dpc-5458	145	55	±4.5	±4.5	PROPN
dpc-5458	145	56	)	)	PUNCT
dpc-5458	145	57	0.113	0.113	NUM
dpc-5458	145	58	5.0	5.0	NUM
dpc-5458	145	59	(	(	PUNCT
dpc-5458	145	60	±3.7	±3.7	NOUN
dpc-5458	145	61	)	)	PUNCT
dpc-5458	145	62	6.4	6.4	NUM
dpc-5458	145	63	(	(	PUNCT
dpc-5458	145	64	±4.5	±4.5	PROPN
dpc-5458	145	65	)	)	PUNCT
dpc-5458	145	66	0.041	0.041	NUM
dpc-5458	145	67	week	week	NOUN
dpc-5458	145	68	24	24	NUM
dpc-5458	145	69	3.6	3.6	NUM
dpc-5458	145	70	(	(	PUNCT
dpc-5458	145	71	±3.7	±3.7	NOUN
dpc-5458	145	72	)	)	PUNCT
dpc-5458	145	73	3.9	3.9	NUM
dpc-5458	145	74	(	(	PUNCT
dpc-5458	145	75	±3.5	±3.5	PROPN
dpc-5458	145	76	)	)	PUNCT
dpc-5458	145	77	5.7	5.7	NUM
dpc-5458	145	78	(	(	PUNCT
dpc-5458	145	79	±5.2	±5.2	NOUN
dpc-5458	145	80	)	)	PUNCT
dpc-5458	145	81	0.040	0.040	NUM
dpc-5458	145	82	3.8	3.8	NUM
dpc-5458	145	83	(	(	PUNCT
dpc-5458	145	84	±3.6	±3.6	PROPN
dpc-5458	145	85	)	)	PUNCT
dpc-5458	145	86	5.7	5.7	NUM
dpc-5458	145	87	(	(	PUNCT
dpc-5458	145	88	±5.2	±5.2	PROPN
dpc-5458	145	89	)	)	PUNCT
dpc-5458	145	90	0.011	0.011	NUM
dpc-5458	145	91	week	week	NOUN
dpc-5458	145	92	48	48	NUM
dpc-5458	145	93	3.2	3.2	NUM
dpc-5458	145	94	(	(	PUNCT
dpc-5458	145	95	±3.7	±3.7	NOUN
dpc-5458	145	96	)	)	PUNCT
dpc-5458	145	97	3.3	3.3	NUM
dpc-5458	145	98	(	(	PUNCT
dpc-5458	145	99	±3.6	±3.6	PROPN
dpc-5458	145	100	)	)	PUNCT
dpc-5458	145	101	5.3	5.3	NUM
dpc-5458	145	102	(	(	PUNCT
dpc-5458	145	103	±5.4	±5.4	PROPN
dpc-5458	145	104	)	)	PUNCT
dpc-5458	145	105	0.032	0.032	NUM
dpc-5458	145	106	3.3	3.3	NUM
dpc-5458	145	107	(	(	PUNCT
dpc-5458	145	108	±3.6	±3.6	PROPN
dpc-5458	145	109	)	)	PUNCT
dpc-5458	145	110	5.3	5.3	NUM
dpc-5458	145	111	(	(	PUNCT
dpc-5458	145	112	±5.4	±5.4	PROPN
dpc-5458	145	113	)	)	PUNCT
dpc-5458	145	114	0.009	0.009	NUM
dpc-5458	146	1	[	[	X
dpc-5458	146	2	14	14	NUM
dpc-5458	146	3	]	]	PUNCT
dpc-5458	146	4	.	.	PUNCT
dpc-5458	147	1	in	in	ADP
dpc-5458	147	2	contrast	contrast	NOUN
dpc-5458	147	3	,	,	PUNCT
dpc-5458	147	4	dmf	dmf	PROPN
dpc-5458	147	5	lacks	lack	VERB
dpc-5458	147	6	cumulative	cumulative	ADJ
dpc-5458	147	7	organ	organ	NOUN
dpc-5458	147	8	toxicity	toxicity	NOUN
dpc-5458	147	9	and	and	CCONJ
dpc-5458	147	10	drug	drug	NOUN
dpc-5458	147	11	–	–	PUNCT
dpc-5458	147	12	drug	drug	NOUN
dpc-5458	147	13	interactions	interaction	NOUN
dpc-5458	147	14	,	,	PUNCT
dpc-5458	147	15	making	make	VERB
dpc-5458	147	16	it	it	PRON
dpc-5458	147	17	suitable	suitable	ADJ
dpc-5458	147	18	for	for	ADP
dpc-5458	147	19	long	long	ADJ
dpc-5458	147	20	-	-	PUNCT
dpc-5458	147	21	term	term	NOUN
dpc-5458	147	22	use	use	NOUN
dpc-5458	147	23	,	,	PUNCT
dpc-5458	147	24	especially	especially	ADV
dpc-5458	147	25	in	in	ADP
dpc-5458	147	26	patients	patient	NOUN
dpc-5458	147	27	with	with	ADP
dpc-5458	147	28	comorbidities	comorbiditie	NOUN
dpc-5458	147	29	or	or	CCONJ
dpc-5458	147	30	when	when	SCONJ
dpc-5458	147	31	immunosuppression	immunosuppression	NOUN
dpc-5458	147	32	is	be	AUX
dpc-5458	147	33	contraindicated	contraindicate	VERB
dpc-5458	147	34	or	or	CCONJ
dpc-5458	147	35	unwanted	unwanted	ADJ
dpc-5458	147	36	[	[	X
dpc-5458	147	37	30	30	NUM
dpc-5458	147	38	]	]	PUNCT
dpc-5458	147	39	.	.	PUNCT
dpc-5458	148	1	table	table	NOUN
dpc-5458	148	2	6	6	NUM
dpc-5458	148	3	summarizes	summarize	NOUN
dpc-5458	148	4	the	the	DET
dpc-5458	148	5	efficacy	efficacy	NOUN
dpc-5458	148	6	,	,	PUNCT
dpc-5458	148	7	safety	safety	NOUN
dpc-5458	148	8	,	,	PUNCT
dpc-5458	148	9	and	and	CCONJ
dpc-5458	148	10	target	target	NOUN
dpc-5458	148	11	populations	population	NOUN
dpc-5458	148	12	of	of	ADP
dpc-5458	148	13	dmf	dmf	PROPN
dpc-5458	148	14	based	base	VERB
dpc-5458	148	15	on	on	ADP
dpc-5458	148	16	real	real	ADJ
dpc-5458	148	17	-	-	PUNCT
dpc-5458	148	18	world	world	NOUN
dpc-5458	148	19	data	datum	NOUN
dpc-5458	148	20	and	and	CCONJ
dpc-5458	148	21	compares	compare	VERB
dpc-5458	148	22	them	they	PRON
dpc-5458	148	23	with	with	ADP
dpc-5458	148	24	other	other	ADJ
dpc-5458	148	25	conventional	conventional	ADJ
dpc-5458	148	26	systemic	systemic	ADJ
dpc-5458	148	27	treatments	treatment	NOUN
dpc-5458	148	28	for	for	ADP
dpc-5458	148	29	psoriasis	psoriasis	NOUN
dpc-5458	148	30	.	.	PUNCT
dpc-5458	149	1	the	the	DET
dpc-5458	149	2	main	main	ADJ
dpc-5458	149	3	limitation	limitation	NOUN
dpc-5458	149	4	of	of	ADP
dpc-5458	149	5	this	this	DET
dpc-5458	149	6	study	study	NOUN
dpc-5458	149	7	is	be	AUX
dpc-5458	149	8	its	its	PRON
dpc-5458	149	9	retrospective	retrospective	ADJ
dpc-5458	149	10	observational	observational	ADJ
dpc-5458	149	11	nature	nature	NOUN
dpc-5458	149	12	,	,	PUNCT
dpc-5458	149	13	which	which	PRON
dpc-5458	149	14	introduces	introduce	VERB
dpc-5458	149	15	the	the	DET
dpc-5458	149	16	potential	potential	NOUN
dpc-5458	149	17	for	for	ADP
dpc-5458	149	18	selection	selection	NOUN
dpc-5458	149	19	bias	bias	NOUN
dpc-5458	149	20	,	,	PUNCT
dpc-5458	149	21	information	information	NOUN
dpc-5458	149	22	bias	bias	NOUN
dpc-5458	149	23	,	,	PUNCT
dpc-5458	149	24	and	and	CCONJ
dpc-5458	149	25	confounding	confound	VERB
dpc-5458	149	26	variables	variable	NOUN
dpc-5458	149	27	and	and	CCONJ
dpc-5458	149	28	does	do	AUX
dpc-5458	149	29	not	not	PART
dpc-5458	149	30	allow	allow	VERB
dpc-5458	149	31	for	for	ADP
dpc-5458	149	32	a	a	DET
dpc-5458	149	33	direct	direct	ADJ
dpc-5458	149	34	comparison	comparison	NOUN
dpc-5458	149	35	between	between	ADP
dpc-5458	149	36	dmf	dmf	PROPN
dpc-5458	149	37	treatment	treatment	NOUN
dpc-5458	149	38	and	and	CCONJ
dpc-5458	149	39	other	other	ADJ
dpc-5458	149	40	conventional	conventional	ADJ
dpc-5458	149	41	or	or	CCONJ
dpc-5458	149	42	biological	biological	ADJ
dpc-5458	149	43	therapies	therapy	NOUN
dpc-5458	149	44	.	.	PUNCT
dpc-5458	150	1	moreover	moreover	ADV
dpc-5458	150	2	,	,	PUNCT
dpc-5458	150	3	although	although	SCONJ
dpc-5458	150	4	the	the	DET
dpc-5458	150	5	total	total	ADJ
dpc-5458	150	6	number	number	NOUN
dpc-5458	150	7	of	of	ADP
dpc-5458	150	8	patients	patient	NOUN
dpc-5458	150	9	enrolled	enrol	VERB
dpc-5458	150	10	is	be	AUX
dpc-5458	150	11	relatively	relatively	ADV
dpc-5458	150	12	high	high	ADJ
dpc-5458	150	13	,	,	PUNCT
dpc-5458	150	14	it	it	PRON
dpc-5458	150	15	should	should	AUX
dpc-5458	150	16	be	be	AUX
dpc-5458	150	17	acknowledged	acknowledge	VERB
dpc-5458	150	18	that	that	SCONJ
dpc-5458	150	19	,	,	PUNCT
dpc-5458	150	20	considering	consider	VERB
dpc-5458	150	21	the	the	DET
dpc-5458	150	22	multicenter	multicenter	ADJ
dpc-5458	150	23	design	design	NOUN
dpc-5458	150	24	,	,	PUNCT
dpc-5458	150	25	the	the	DET
dpc-5458	150	26	sample	sample	NOUN
dpc-5458	150	27	size	size	NOUN
dpc-5458	150	28	could	could	AUX
dpc-5458	150	29	have	have	AUX
dpc-5458	150	30	been	be	AUX
dpc-5458	150	31	larger	large	ADJ
dpc-5458	150	32	to	to	PART
dpc-5458	150	33	enhance	enhance	VERB
dpc-5458	150	34	the	the	DET
dpc-5458	150	35	statistical	statistical	ADJ
dpc-5458	150	36	power	power	NOUN
dpc-5458	150	37	and	and	CCONJ
dpc-5458	150	38	generalizability	generalizability	NOUN
dpc-5458	150	39	of	of	ADP
dpc-5458	150	40	the	the	DET
dpc-5458	150	41	findings	finding	NOUN
dpc-5458	150	42	.	.	PUNCT
dpc-5458	151	1	conclusions	conclusion	NOUN
dpc-5458	151	2	our	our	PRON
dpc-5458	151	3	study	study	NOUN
dpc-5458	151	4	confirms	confirm	VERB
dpc-5458	151	5	that	that	SCONJ
dpc-5458	151	6	,	,	PUNCT
dpc-5458	151	7	when	when	SCONJ
dpc-5458	151	8	tolerated	tolerate	VERB
dpc-5458	151	9	,	,	PUNCT
dpc-5458	151	10	dmf	dmf	PROPN
dpc-5458	151	11	represents	represent	VERB
dpc-5458	151	12	a	a	DET
dpc-5458	151	13	valuable	valuable	ADJ
dpc-5458	151	14	first	first	ADJ
dpc-5458	151	15	-	-	PUNCT
dpc-5458	151	16	line	line	NOUN
dpc-5458	151	17	systemic	systemic	ADJ
dpc-5458	151	18	therapeutic	therapeutic	ADJ
dpc-5458	151	19	option	option	NOUN
dpc-5458	151	20	for	for	ADP
dpc-5458	151	21	patients	patient	NOUN
dpc-5458	151	22	with	with	ADP
dpc-5458	151	23	moderate	moderate	ADJ
dpc-5458	151	24	psoriasis	psoriasis	NOUN
dpc-5458	151	25	as	as	SCONJ
dpc-5458	151	26	it	it	PRON
dpc-5458	151	27	can	can	AUX
dpc-5458	151	28	induce	induce	VERB
dpc-5458	151	29	long	long	ADJ
dpc-5458	151	30	-	-	PUNCT
dpc-5458	151	31	term	term	NOUN
dpc-5458	151	32	disease	disease	NOUN
dpc-5458	151	33	remission	remission	NOUN
dpc-5458	151	34	while	while	SCONJ
dpc-5458	151	35	maintaining	maintain	VERB
dpc-5458	151	36	a	a	DET
dpc-5458	151	37	good	good	ADJ
dpc-5458	151	38	safety	safety	NOUN
dpc-5458	151	39	profile	profile	NOUN
dpc-5458	151	40	.	.	PUNCT
dpc-5458	152	1	dmf	dmf	PROPN
dpc-5458	152	2	should	should	AUX
dpc-5458	152	3	be	be	AUX
dpc-5458	152	4	offered	offer	VERB
dpc-5458	152	5	early	early	ADV
dpc-5458	152	6	in	in	ADP
dpc-5458	152	7	the	the	DET
dpc-5458	152	8	therapeutic	therapeutic	ADJ
dpc-5458	152	9	journey	journey	NOUN
dpc-5458	152	10	as	as	SCONJ
dpc-5458	152	11	this	this	DET
dpc-5458	152	12	study	study	NOUN
dpc-5458	152	13	shows	show	VERB
dpc-5458	152	14	that	that	SCONJ
dpc-5458	152	15	it	it	PRON
dpc-5458	152	16	is	be	AUX
dpc-5458	152	17	more	more	ADV
dpc-5458	152	18	efficacious	efficacious	ADJ
dpc-5458	152	19	and	and	CCONJ
dpc-5458	152	20	safer	safe	ADJ
dpc-5458	152	21	for	for	ADP
dpc-5458	152	22	patients	patient	NOUN
dpc-5458	152	23	with	with	ADP
dpc-5458	152	24	a	a	DET
dpc-5458	152	25	disease	disease	NOUN
dpc-5458	152	26	duration	duration	NOUN
dpc-5458	152	27	of	of	ADP
dpc-5458	152	28	less	less	ADJ
dpc-5458	152	29	than	than	ADP
dpc-5458	152	30	five	five	NUM
dpc-5458	152	31	years	year	NOUN
dpc-5458	152	32	.	.	PUNCT
dpc-5458	153	1	dmf	dmf	PROPN
dpc-5458	153	2	is	be	AUX
dpc-5458	153	3	particularly	particularly	ADV
dpc-5458	153	4	suitable	suitable	ADJ
dpc-5458	153	5	as	as	ADP
dpc-5458	153	6	first	first	ADJ
dpc-5458	153	7	-	-	PUNCT
dpc-5458	153	8	line	line	NOUN
dpc-5458	153	9	therapy	therapy	NOUN
dpc-5458	153	10	in	in	ADP
dpc-5458	153	11	cases	case	NOUN
dpc-5458	153	12	where	where	SCONJ
dpc-5458	153	13	immunosuppression	immunosuppression	NOUN
dpc-5458	153	14	is	be	AUX
dpc-5458	153	15	undesired	undesired	ADJ
dpc-5458	153	16	or	or	CCONJ
dpc-5458	153	17	when	when	SCONJ
dpc-5458	153	18	patients	patient	NOUN
dpc-5458	153	19	are	be	AUX
dpc-5458	153	20	on	on	ADP
dpc-5458	153	21	multi	multi	ADJ
dpc-5458	153	22	-	-	ADJ
dpc-5458	153	23	drug	drug	ADJ
dpc-5458	153	24	therapy	therapy	NOUN
dpc-5458	153	25	as	as	SCONJ
dpc-5458	153	26	it	it	PRON
dpc-5458	153	27	does	do	AUX
dpc-5458	153	28	not	not	PART
dpc-5458	153	29	exhibit	exhibit	VERB
dpc-5458	153	30	any	any	DET
dpc-5458	153	31	drug	drug	NOUN
dpc-5458	153	32	–	–	PUNCT
dpc-5458	153	33	drug	drug	NOUN
dpc-5458	153	34	interaction	interaction	NOUN
dpc-5458	153	35	or	or	CCONJ
dpc-5458	153	36	8	8	NUM
dpc-5458	153	37	original	original	ADJ
dpc-5458	153	38	article	article	NOUN
dpc-5458	153	39	|	|	ADV
dpc-5458	153	40	dermatol	dermatol	ADJ
dpc-5458	153	41	pract	pract	NOUN
dpc-5458	153	42	concept	concept	NOUN
dpc-5458	153	43	.	.	PUNCT
dpc-5458	154	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	154	2	figure	figure	NOUN
dpc-5458	154	3	3	3	NUM
dpc-5458	154	4	.	.	PUNCT
dpc-5458	155	1	mean	mean	PROPN
dpc-5458	155	2	pasi	pasi	NOUN
dpc-5458	155	3	by	by	ADP
dpc-5458	155	4	visit	visit	NOUN
dpc-5458	155	5	and	and	CCONJ
dpc-5458	155	6	disease	disease	NOUN
dpc-5458	155	7	duration	duration	NOUN
dpc-5458	155	8	analyzed	analyze	VERB
dpc-5458	155	9	using	use	VERB
dpc-5458	155	10	the	the	DET
dpc-5458	155	11	last	last	ADJ
dpc-5458	155	12	observation	observation	NOUN
dpc-5458	155	13	carried	carry	VERB
dpc-5458	155	14	forward	forward	ADV
dpc-5458	155	15	analysis	analysis	NOUN
dpc-5458	155	16	(	(	PUNCT
dpc-5458	155	17	locf	locf	PROPN
dpc-5458	155	18	)	)	PUNCT
dpc-5458	155	19	.	.	PUNCT
dpc-5458	156	1	table	table	NOUN
dpc-5458	156	2	6	6	NUM
dpc-5458	156	3	.	.	PUNCT
dpc-5458	156	4	comparison	comparison	NOUN
dpc-5458	156	5	between	between	ADP
dpc-5458	156	6	these	these	DET
dpc-5458	156	7	real	real	ADJ
dpc-5458	156	8	-	-	PUNCT
dpc-5458	156	9	world	world	NOUN
dpc-5458	156	10	data	datum	NOUN
dpc-5458	156	11	on	on	ADP
dpc-5458	156	12	dimethyl	dimethyl	NOUN
dpc-5458	156	13	fumarate	fumarate	NOUN
dpc-5458	156	14	and	and	CCONJ
dpc-5458	156	15	efficacy	efficacy	NOUN
dpc-5458	156	16	and	and	CCONJ
dpc-5458	156	17	safety	safety	NOUN
dpc-5458	156	18	of	of	ADP
dpc-5458	156	19	other	other	ADJ
dpc-5458	156	20	conventional	conventional	ADJ
dpc-5458	156	21	systemic	systemic	ADJ
dpc-5458	156	22	treatments	treatment	NOUN
dpc-5458	156	23	of	of	ADP
dpc-5458	156	24	psoriasis	psoriasis	NOUN
dpc-5458	156	25	.	.	PUNCT
dpc-5458	157	1	parameter	parameter	PROPN
dpc-5458	157	2	dimethyl	dimethyl	PROPN
dpc-5458	157	3	fumarate	fumarate	NOUN
dpc-5458	158	1	[	[	X
dpc-5458	158	2	current	current	ADJ
dpc-5458	158	3	study	study	NOUN
dpc-5458	158	4	]	]	PUNCT
dpc-5458	158	5	methotrexate	methotrexate	NOUN
dpc-5458	159	1	[	[	X
dpc-5458	159	2	27,28	27,28	X
dpc-5458	159	3	]	]	X
dpc-5458	159	4	cyclosporin	cyclosporin	NOUN
dpc-5458	159	5	[	[	X
dpc-5458	159	6	29	29	NUM
dpc-5458	159	7	]	]	X
dpc-5458	159	8	acitretin	acitretin	NOUN
dpc-5458	159	9	[	[	X
dpc-5458	159	10	14	14	NUM
dpc-5458	159	11	]	]	SYM
dpc-5458	159	12	efficacy	efficacy	NOUN
dpc-5458	159	13	moderate	moderate	ADJ
dpc-5458	159	14	efficacy	efficacy	NOUN
dpc-5458	159	15	;	;	PUNCT
dpc-5458	159	16	suitable	suitable	ADJ
dpc-5458	159	17	for	for	ADP
dpc-5458	159	18	long	long	ADJ
dpc-5458	159	19	-	-	PUNCT
dpc-5458	159	20	term	term	NOUN
dpc-5458	159	21	management	management	NOUN
dpc-5458	159	22	.	.	PUNCT
dpc-5458	160	1	pasi	pasi	NOUN
dpc-5458	160	2	response	response	NOUN
dpc-5458	160	3	lower	low	ADJ
dpc-5458	160	4	than	than	SCONJ
dpc-5458	160	5	methotrexate	methotrexate	VERB
dpc-5458	160	6	moderate	moderate	ADJ
dpc-5458	160	7	efficacy	efficacy	NOUN
dpc-5458	160	8	in	in	ADP
dpc-5458	160	9	chronic	chronic	ADJ
dpc-5458	160	10	plaque	plaque	NOUN
dpc-5458	160	11	psoriasis	psoriasis	NOUN
dpc-5458	160	12	and	and	CCONJ
dpc-5458	160	13	psa	psa	VERB
dpc-5458	160	14	high	high	ADJ
dpc-5458	160	15	short	short	ADJ
dpc-5458	160	16	-	-	PUNCT
dpc-5458	160	17	term	term	NOUN
dpc-5458	160	18	efficacy	efficacy	NOUN
dpc-5458	160	19	;	;	PUNCT
dpc-5458	160	20	ideal	ideal	ADJ
dpc-5458	160	21	for	for	ADP
dpc-5458	160	22	rapid	rapid	ADJ
dpc-5458	160	23	disease	disease	NOUN
dpc-5458	160	24	control	control	NOUN
dpc-5458	160	25	in	in	ADP
dpc-5458	160	26	severe	severe	ADJ
dpc-5458	160	27	psoriasis	psoriasis	NOUN
dpc-5458	160	28	moderate	moderate	ADJ
dpc-5458	160	29	efficacy	efficacy	NOUN
dpc-5458	160	30	,	,	PUNCT
dpc-5458	160	31	especially	especially	ADV
dpc-5458	160	32	in	in	ADP
dpc-5458	160	33	pustular/	pustular/	NUM
dpc-5458	160	34	erythrodermic	erythrodermic	ADJ
dpc-5458	160	35	psoriasis	psoriasis	NOUN
dpc-5458	160	36	;	;	PUNCT
dpc-5458	160	37	improved	improve	VERB
dpc-5458	160	38	with	with	ADP
dpc-5458	160	39	phototherapy	phototherapy	NOUN
dpc-5458	160	40	onset	onset	NOUN
dpc-5458	160	41	of	of	ADP
dpc-5458	160	42	action	action	NOUN
dpc-5458	160	43	gradual	gradual	ADJ
dpc-5458	160	44	;	;	PUNCT
dpc-5458	160	45	improvement	improvement	NOUN
dpc-5458	160	46	over	over	ADP
dpc-5458	160	47	weeks	week	NOUN
dpc-5458	160	48	to	to	ADP
dpc-5458	160	49	months	month	NOUN
dpc-5458	160	50	moderate	moderate	ADJ
dpc-5458	160	51	onset	onset	VERB
dpc-5458	160	52	rapid	rapid	ADJ
dpc-5458	160	53	onset	onset	NOUN
dpc-5458	160	54	;	;	PUNCT
dpc-5458	160	55	ideal	ideal	ADJ
dpc-5458	160	56	for	for	ADP
dpc-5458	160	57	acute	acute	ADJ
dpc-5458	160	58	flares	flare	NOUN
dpc-5458	160	59	intermediate	intermediate	ADJ
dpc-5458	160	60	onset	onset	NOUN
dpc-5458	160	61	tolerability	tolerability	NOUN
dpc-5458	160	62	generally	generally	ADV
dpc-5458	160	63	good	good	ADJ
dpc-5458	160	64	;	;	PUNCT
dpc-5458	160	65	adverse	adverse	ADJ
dpc-5458	160	66	events	event	NOUN
dpc-5458	160	67	are	be	AUX
dpc-5458	160	68	mostly	mostly	ADV
dpc-5458	160	69	early	early	ADJ
dpc-5458	160	70	,	,	PUNCT
dpc-5458	160	71	mild	mild	ADJ
dpc-5458	160	72	,	,	PUNCT
dpc-5458	160	73	and	and	CCONJ
dpc-5458	160	74	reversible	reversible	ADJ
dpc-5458	160	75	(	(	PUNCT
dpc-5458	160	76	gi	gi	INTJ
dpc-5458	160	77	upset	upset	ADJ
dpc-5458	160	78	,	,	PUNCT
dpc-5458	160	79	flushing	flush	VERB
dpc-5458	160	80	)	)	PUNCT
dpc-5458	160	81	;	;	PUNCT
dpc-5458	160	82	most	most	ADJ
dpc-5458	160	83	discontinuations	discontinuation	NOUN
dpc-5458	160	84	occur	occur	VERB
dpc-5458	160	85	early	early	ADV
dpc-5458	160	86	requires	require	VERB
dpc-5458	160	87	regular	regular	ADJ
dpc-5458	160	88	monitoring	monitoring	NOUN
dpc-5458	160	89	due	due	ADP
dpc-5458	160	90	to	to	ADP
dpc-5458	160	91	hepatotoxicity	hepatotoxicity	NOUN
dpc-5458	160	92	,	,	PUNCT
dpc-5458	160	93	gi	gi	NOUN
dpc-5458	160	94	effects	effect	NOUN
dpc-5458	160	95	,	,	PUNCT
dpc-5458	160	96	and	and	CCONJ
dpc-5458	160	97	myelosuppression	myelosuppression	NOUN
dpc-5458	160	98	risks	risk	NOUN
dpc-5458	160	99	limited	limit	VERB
dpc-5458	160	100	by	by	ADP
dpc-5458	160	101	nephrotoxicity	nephrotoxicity	NOUN
dpc-5458	160	102	,	,	PUNCT
dpc-5458	160	103	hypertension	hypertension	NOUN
dpc-5458	160	104	,	,	PUNCT
dpc-5458	160	105	and	and	CCONJ
dpc-5458	160	106	metabolic	metabolic	NOUN
dpc-5458	160	107	issues	issue	NOUN
dpc-5458	160	108	;	;	PUNCT
dpc-5458	160	109	requires	require	VERB
dpc-5458	160	110	intermittent	intermittent	ADJ
dpc-5458	160	111	shortcourse	shortcourse	ADJ
dpc-5458	160	112	use	use	NOUN
dpc-5458	160	113	(	(	PUNCT
dpc-5458	160	114	max	max	X
dpc-5458	160	115	~1	~1	ADJ
dpc-5458	160	116	year	year	NOUN
dpc-5458	160	117	)	)	PUNCT
dpc-5458	160	118	mucocutaneous	mucocutaneous	ADJ
dpc-5458	160	119	aes	aes	PROPN
dpc-5458	160	120	common	common	ADJ
dpc-5458	160	121	(	(	PUNCT
dpc-5458	160	122	dryness	dryness	NOUN
dpc-5458	160	123	,	,	PUNCT
dpc-5458	160	124	cheilitis	cheilitis	NOUN
dpc-5458	160	125	)	)	PUNCT
dpc-5458	160	126	;	;	PUNCT
dpc-5458	160	127	lipid/	lipid/	NUM
dpc-5458	160	128	liver	liver	NOUN
dpc-5458	160	129	changes	change	NOUN
dpc-5458	160	130	require	require	VERB
dpc-5458	160	131	monitoring	monitor	VERB
dpc-5458	160	132	long	long	ADJ
dpc-5458	160	133	-	-	PUNCT
dpc-5458	160	134	term	term	NOUN
dpc-5458	160	135	safety	safety	NOUN
dpc-5458	160	136	favorable	favorable	ADJ
dpc-5458	160	137	;	;	PUNCT
dpc-5458	160	138	lacks	lack	VERB
dpc-5458	160	139	cumulative	cumulative	ADJ
dpc-5458	160	140	organ	organ	NOUN
dpc-5458	160	141	toxicity	toxicity	NOUN
dpc-5458	160	142	and	and	CCONJ
dpc-5458	160	143	drug	drug	NOUN
dpc-5458	160	144	–	–	PUNCT
dpc-5458	160	145	drug	drug	NOUN
dpc-5458	160	146	interactions	interaction	NOUN
dpc-5458	160	147	risk	risk	NOUN
dpc-5458	160	148	of	of	ADP
dpc-5458	160	149	liver	liver	NOUN
dpc-5458	160	150	fibrosis	fibrosis	NOUN
dpc-5458	160	151	and	and	CCONJ
dpc-5458	160	152	bone	bone	NOUN
dpc-5458	160	153	marrow	marrow	NOUN
dpc-5458	160	154	suppression	suppression	NOUN
dpc-5458	160	155	with	with	ADP
dpc-5458	160	156	long	long	ADJ
dpc-5458	160	157	-	-	PUNCT
dpc-5458	160	158	term	term	NOUN
dpc-5458	160	159	use	use	NOUN
dpc-5458	160	160	not	not	PART
dpc-5458	160	161	recommended	recommend	VERB
dpc-5458	160	162	beyond	beyond	ADP
dpc-5458	160	163	1	1	NUM
dpc-5458	160	164	year	year	NOUN
dpc-5458	160	165	due	due	ADP
dpc-5458	160	166	to	to	ADP
dpc-5458	160	167	renal	renal	ADJ
dpc-5458	160	168	/	/	SYM
dpc-5458	160	169	metabolic	metabolic	NOUN
dpc-5458	160	170	toxicity	toxicity	NOUN
dpc-5458	160	171	risks	risk	NOUN
dpc-5458	160	172	teratogenicity	teratogenicity	NOUN
dpc-5458	160	173	(	(	PUNCT
dpc-5458	160	174	up	up	ADP
dpc-5458	160	175	to	to	PART
dpc-5458	160	176	3	3	NUM
dpc-5458	160	177	years	year	NOUN
dpc-5458	160	178	post	post	ADJ
dpc-5458	160	179	-	-	NOUN
dpc-5458	160	180	therapy	therapy	NOUN
dpc-5458	160	181	)	)	PUNCT
dpc-5458	160	182	,	,	PUNCT
dpc-5458	160	183	hepatotoxicity	hepatotoxicity	NOUN
dpc-5458	160	184	,	,	PUNCT
dpc-5458	160	185	and	and	CCONJ
dpc-5458	160	186	hyperlipidemia	hyperlipidemia	NOUN
dpc-5458	160	187	may	may	AUX
dpc-5458	160	188	limit	limit	VERB
dpc-5458	160	189	use	use	VERB
dpc-5458	160	190	immunosuppressive	immunosuppressive	ADJ
dpc-5458	160	191	activity	activity	NOUN
dpc-5458	161	1	no	no	INTJ
dpc-5458	162	1	yes	yes	INTJ
dpc-5458	162	2	yes	yes	INTJ
dpc-5458	162	3	no	no	DET
dpc-5458	162	4	best	well	ADV
dpc-5458	162	5	-	-	PUNCT
dpc-5458	162	6	suited	suit	VERB
dpc-5458	162	7	patients	patient	NOUN
dpc-5458	162	8	patients	patient	NOUN
dpc-5458	162	9	with	with	ADP
dpc-5458	162	10	comorbidities	comorbiditie	NOUN
dpc-5458	162	11	,	,	PUNCT
dpc-5458	162	12	contraindications	contraindication	NOUN
dpc-5458	162	13	to	to	ADP
dpc-5458	162	14	immunosuppressants	immunosuppressant	NOUN
dpc-5458	162	15	,	,	PUNCT
dpc-5458	162	16	or	or	CCONJ
dpc-5458	162	17	requiring	require	VERB
dpc-5458	162	18	long	long	ADJ
dpc-5458	162	19	-	-	PUNCT
dpc-5458	162	20	term	term	NOUN
dpc-5458	162	21	treatment	treatment	NOUN
dpc-5458	162	22	patients	patient	NOUN
dpc-5458	162	23	with	with	ADP
dpc-5458	162	24	extensive	extensive	ADJ
dpc-5458	162	25	plaque	plaque	NOUN
dpc-5458	162	26	psoriasis	psoriasis	NOUN
dpc-5458	162	27	or	or	CCONJ
dpc-5458	162	28	joint	joint	ADJ
dpc-5458	162	29	involvement	involvement	NOUN
dpc-5458	162	30	and	and	CCONJ
dpc-5458	162	31	no	no	DET
dpc-5458	162	32	hepatic	hepatic	ADJ
dpc-5458	162	33	or	or	CCONJ
dpc-5458	162	34	hematological	hematological	ADJ
dpc-5458	162	35	contraindications	contraindication	NOUN
dpc-5458	162	36	patients	patient	NOUN
dpc-5458	162	37	with	with	ADP
dpc-5458	162	38	rapidly	rapidly	ADV
dpc-5458	162	39	progressive	progressive	ADJ
dpc-5458	162	40	,	,	PUNCT
dpc-5458	162	41	severe	severe	ADJ
dpc-5458	162	42	disease	disease	NOUN
dpc-5458	162	43	requiring	require	VERB
dpc-5458	162	44	fast	fast	ADJ
dpc-5458	162	45	symptom	symptom	NOUN
dpc-5458	162	46	control	control	NOUN
dpc-5458	162	47	male	male	NOUN
dpc-5458	162	48	or	or	CCONJ
dpc-5458	162	49	postmenopausal	postmenopausal	ADJ
dpc-5458	162	50	patients	patient	NOUN
dpc-5458	162	51	with	with	ADP
dpc-5458	162	52	keratinization	keratinization	NOUN
dpc-5458	162	53	disorders	disorder	NOUN
dpc-5458	162	54	or	or	CCONJ
dpc-5458	162	55	pustular/	pustular/	NUM
dpc-5458	162	56	erythrodermic	erythrodermic	ADJ
dpc-5458	162	57	psoriasis	psoriasis	NOUN
dpc-5458	162	58	;	;	PUNCT
dpc-5458	162	59	not	not	PART
dpc-5458	162	60	for	for	ADP
dpc-5458	162	61	women	woman	NOUN
dpc-5458	162	62	of	of	ADP
dpc-5458	162	63	childbearing	childbeare	VERB
dpc-5458	162	64	potential	potential	ADJ
dpc-5458	162	65	abbreviations	abbreviation	NOUN
dpc-5458	162	66	:	:	PUNCT
dpc-5458	162	67	ae	ae	PROPN
dpc-5458	162	68	:	:	PUNCT
dpc-5458	162	69	adverse	adverse	ADJ
dpc-5458	162	70	event	event	NOUN
dpc-5458	162	71	;	;	PUNCT
dpc-5458	162	72	gi	gi	NOUN
dpc-5458	162	73	:	:	PUNCT
dpc-5458	162	74	gastrointestinal	gastrointestinal	ADJ
dpc-5458	162	75	;	;	PUNCT
dpc-5458	162	76	pasi	pasi	NOUN
dpc-5458	162	77	:	:	PUNCT
dpc-5458	162	78	psoriasis	psoriasis	NOUN
dpc-5458	162	79	area	area	NOUN
dpc-5458	162	80	severity	severity	NOUN
dpc-5458	162	81	index	index	NOUN
dpc-5458	162	82	;	;	PUNCT
dpc-5458	162	83	psa	psa	VERB
dpc-5458	162	84	:	:	PUNCT
dpc-5458	162	85	psoriatic	psoriatic	ADJ
dpc-5458	162	86	arthritis	arthritis	NOUN
dpc-5458	162	87	.	.	PUNCT
dpc-5458	163	1	original	original	ADJ
dpc-5458	163	2	article	article	NOUN
dpc-5458	163	3	|	|	ADV
dpc-5458	163	4	dermatol	dermatol	ADJ
dpc-5458	163	5	pract	pract	NOUN
dpc-5458	163	6	concept	concept	NOUN
dpc-5458	163	7	.	.	PUNCT
dpc-5458	164	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	164	2	9	9	NUM
dpc-5458	164	3	cumulative	cumulative	ADJ
dpc-5458	164	4	organ	organ	NOUN
dpc-5458	164	5	toxicities	toxicity	NOUN
dpc-5458	164	6	.	.	PUNCT
dpc-5458	165	1	further	further	ADJ
dpc-5458	165	2	real	real	ADJ
dpc-5458	165	3	-	-	PUNCT
dpc-5458	165	4	world	world	NOUN
dpc-5458	165	5	evidence	evidence	NOUN
dpc-5458	165	6	is	be	AUX
dpc-5458	165	7	desiderable	desiderable	ADJ
dpc-5458	165	8	to	to	PART
dpc-5458	165	9	support	support	VERB
dpc-5458	165	10	these	these	DET
dpc-5458	165	11	findings	finding	NOUN
dpc-5458	165	12	.	.	PUNCT
dpc-5458	166	1	ethics	ethic	NOUN
dpc-5458	166	2	:	:	PUNCT
dpc-5458	166	3	the	the	DET
dpc-5458	166	4	investigation	investigation	NOUN
dpc-5458	166	5	was	be	AUX
dpc-5458	166	6	conducted	conduct	VERB
dpc-5458	166	7	in	in	ADP
dpc-5458	166	8	accordance	accordance	NOUN
dpc-5458	166	9	with	with	ADP
dpc-5458	166	10	the	the	DET
dpc-5458	166	11	helsinki	helsinki	PROPN
dpc-5458	166	12	declaration	declaration	PROPN
dpc-5458	166	13	,	,	PUNCT
dpc-5458	166	14	and	and	CCONJ
dpc-5458	166	15	the	the	DET
dpc-5458	166	16	use	use	NOUN
dpc-5458	166	17	of	of	ADP
dpc-5458	166	18	the	the	DET
dpc-5458	166	19	drug	drug	NOUN
dpc-5458	166	20	was	be	AUX
dpc-5458	166	21	made	make	VERB
dpc-5458	166	22	according	accord	VERB
dpc-5458	166	23	to	to	ADP
dpc-5458	166	24	normal	normal	ADJ
dpc-5458	166	25	clinical	clinical	ADJ
dpc-5458	166	26	practice	practice	NOUN
dpc-5458	166	27	and	and	CCONJ
dpc-5458	166	28	technical	technical	ADJ
dpc-5458	166	29	data	datum	NOUN
dpc-5458	166	30	sheet	sheet	NOUN
dpc-5458	166	31	.	.	PUNCT
dpc-5458	167	1	patients	patient	NOUN
dpc-5458	167	2	signed	sign	VERB
dpc-5458	167	3	a	a	DET
dpc-5458	167	4	declaration	declaration	NOUN
dpc-5458	167	5	allowing	allow	VERB
dpc-5458	167	6	the	the	DET
dpc-5458	167	7	use	use	NOUN
dpc-5458	167	8	of	of	ADP
dpc-5458	167	9	their	their	PRON
dpc-5458	167	10	clinical	clinical	ADJ
dpc-5458	167	11	records	record	NOUN
dpc-5458	167	12	for	for	ADP
dpc-5458	167	13	scientific	scientific	ADJ
dpc-5458	167	14	purposes	purpose	NOUN
dpc-5458	167	15	.	.	PUNCT
dpc-5458	168	1	acknowledgments	acknowledgment	NOUN
dpc-5458	168	2	:	:	PUNCT
dpc-5458	168	3	the	the	DET
dpc-5458	168	4	authors	author	NOUN
dpc-5458	168	5	acknowledge	acknowledge	VERB
dpc-5458	168	6	lara	lara	PROPN
dpc-5458	168	7	vecchi	vecchi	PROPN
dpc-5458	168	8	,	,	PUNCT
dpc-5458	168	9	valentina	valentina	PROPN
dpc-5458	168	10	attanasio	attanasio	NOUN
dpc-5458	168	11	,	,	PUNCT
dpc-5458	168	12	and	and	CCONJ
dpc-5458	168	13	aashni	aashni	ADP
dpc-5458	168	14	shah	shah	NOUN
dpc-5458	168	15	(	(	PUNCT
dpc-5458	168	16	polistudium	polistudium	NOUN
dpc-5458	168	17	srl	srl	PROPN
dpc-5458	168	18	,	,	PUNCT
dpc-5458	168	19	milan	milan	PROPN
dpc-5458	168	20	,	,	PUNCT
dpc-5458	168	21	italy	italy	PROPN
dpc-5458	168	22	)	)	PUNCT
dpc-5458	168	23	for	for	ADP
dpc-5458	168	24	editorial	editorial	ADJ
dpc-5458	168	25	assistance	assistance	NOUN
dpc-5458	168	26	and	and	CCONJ
dpc-5458	168	27	massimiliano	massimiliano	PROPN
dpc-5458	168	28	pianta	pianta	PROPN
dpc-5458	168	29	(	(	PUNCT
dpc-5458	168	30	polistudium	polistudium	PROPN
dpc-5458	168	31	srl	srl	PROPN
dpc-5458	168	32	,	,	PUNCT
dpc-5458	168	33	milan	milan	PROPN
dpc-5458	168	34	,	,	PUNCT
dpc-5458	168	35	italy	italy	PROPN
dpc-5458	168	36	)	)	PUNCT
dpc-5458	168	37	for	for	ADP
dpc-5458	168	38	graphic	graphic	ADJ
dpc-5458	168	39	support	support	NOUN
dpc-5458	168	40	.	.	PUNCT
dpc-5458	169	1	references	reference	NOUN
dpc-5458	169	2	1	1	NUM
dpc-5458	169	3	.	.	PUNCT
dpc-5458	169	4	griffiths	griffiths	PROPN
dpc-5458	169	5	cem	cem	PROPN
dpc-5458	169	6	,	,	PUNCT
dpc-5458	169	7	armstrong	armstrong	PROPN
dpc-5458	169	8	aw	aw	INTJ
dpc-5458	169	9	,	,	PUNCT
dpc-5458	169	10	gudjonsson	gudjonsson	PROPN
dpc-5458	169	11	je	je	PROPN
dpc-5458	169	12	,	,	PUNCT
dpc-5458	169	13	barker	barker	PROPN
dpc-5458	169	14	jnwn	jnwn	PROPN
dpc-5458	169	15	.	.	PUNCT
dpc-5458	170	1	psoriasis	psoriasis	NOUN
dpc-5458	170	2	.	.	PUNCT
dpc-5458	171	1	lancet	lancet	PROPN
dpc-5458	171	2	.	.	PUNCT
dpc-5458	172	1	2021;397(10281):1301	2021;397(10281):1301	NUM
dpc-5458	172	2	-	-	SYM
dpc-5458	172	3	1315	1315	NUM
dpc-5458	172	4	.	.	PUNCT
dpc-5458	173	1	doi	doi	NOUN
dpc-5458	173	2	:	:	PUNCT
dpc-5458	173	3	10.1016	10.1016	NUM
dpc-5458	173	4	/s0140	/s0140	PROPN
dpc-5458	173	5	-	-	PUNCT
dpc-5458	173	6	6736(20)32549	6736(20)32549	NUM
dpc-5458	173	7	-	-	PUNCT
dpc-5458	173	8	6	6	NUM
dpc-5458	173	9	.	.	PUNCT
dpc-5458	174	1	pmid	pmid	NOUN
dpc-5458	174	2	:	:	PUNCT
dpc-5458	174	3	33812489	33812489	NUM
dpc-5458	174	4	.	.	PUNCT
dpc-5458	175	1	2	2	X
dpc-5458	175	2	.	.	X
dpc-5458	175	3	nast	nast	PROPN
dpc-5458	175	4	a	a	PROPN
dpc-5458	175	5	,	,	PUNCT
dpc-5458	175	6	smith	smith	PROPN
dpc-5458	175	7	c	c	PROPN
dpc-5458	175	8	,	,	PUNCT
dpc-5458	175	9	spuls	spuls	PROPN
dpc-5458	175	10	pi	pi	PROPN
dpc-5458	175	11	,	,	PUNCT
dpc-5458	175	12	et	et	PROPN
dpc-5458	175	13	al	al	PROPN
dpc-5458	175	14	.	.	PROPN
dpc-5458	176	1	euroguiderm	euroguiderm	PROPN
dpc-5458	176	2	guideline	guideline	NOUN
dpc-5458	176	3	on	on	ADP
dpc-5458	176	4	the	the	DET
dpc-5458	176	5	systemic	systemic	ADJ
dpc-5458	176	6	treatment	treatment	NOUN
dpc-5458	176	7	of	of	ADP
dpc-5458	176	8	psoriasis	psoriasis	NOUN
dpc-5458	176	9	vulgaris	vulgaris	NOUN
dpc-5458	176	10	part	part	NOUN
dpc-5458	176	11	1	1	NUM
dpc-5458	176	12	:	:	PUNCT
dpc-5458	176	13	treatment	treatment	NOUN
dpc-5458	176	14	and	and	CCONJ
dpc-5458	176	15	monitoring	monitoring	NOUN
dpc-5458	176	16	recommendations	recommendation	NOUN
dpc-5458	176	17	.	.	PUNCT
dpc-5458	177	1	j	j	PROPN
dpc-5458	177	2	eur	eur	PROPN
dpc-5458	177	3	acad	acad	PROPN
dpc-5458	177	4	dermatol	dermatol	NOUN
dpc-5458	177	5	venereol	venereol	NOUN
dpc-5458	177	6	.	.	PUNCT
dpc-5458	178	1	2020;34(11):2461	2020;34(11):2461	X
dpc-5458	178	2	-	-	PROPN
dpc-5458	178	3	2498	2498	NUM
dpc-5458	178	4	.	.	PUNCT
dpc-5458	179	1	doi	doi	NOUN
dpc-5458	179	2	:	:	PUNCT
dpc-5458	179	3	10.1111	10.1111	NUM
dpc-5458	179	4	/	/	SYM
dpc-5458	179	5	jdv.16915	jdv.16915	NOUN
dpc-5458	179	6	.	.	PUNCT
dpc-5458	180	1	pmid	pmid	NOUN
dpc-5458	180	2	:	:	PUNCT
dpc-5458	180	3	33349983	33349983	NUM
dpc-5458	180	4	.	.	PUNCT
dpc-5458	181	1	3	3	X
dpc-5458	181	2	.	.	X
dpc-5458	181	3	wride	wride	ADP
dpc-5458	181	4	am	am	PROPN
dpc-5458	181	5	,	,	PUNCT
dpc-5458	181	6	chen	chen	PROPN
dpc-5458	181	7	gf	gf	PROPN
dpc-5458	181	8	,	,	PUNCT
dpc-5458	181	9	spaulding	spaulding	PROPN
dpc-5458	181	10	sl	sl	PROPN
dpc-5458	181	11	,	,	PUNCT
dpc-5458	181	12	tkachenko	tkachenko	NOUN
dpc-5458	181	13	e	e	PROPN
dpc-5458	181	14	,	,	PUNCT
dpc-5458	181	15	cohen	cohen	PROPN
dpc-5458	181	16	jm	jm	PROPN
dpc-5458	181	17	.	.	PROPN
dpc-5458	181	18	biologics	biologic	NOUN
dpc-5458	181	19	for	for	ADP
dpc-5458	181	20	psoriasis	psoriasis	NOUN
dpc-5458	181	21	.	.	PUNCT
dpc-5458	182	1	dermatol	dermatol	NOUN
dpc-5458	182	2	clin	clin	PROPN
dpc-5458	182	3	.	.	PUNCT
dpc-5458	183	1	2024;42(3):339	2024;42(3):339	NUM
dpc-5458	183	2	-	-	SYM
dpc-5458	183	3	355	355	NUM
dpc-5458	183	4	.	.	PUNCT
dpc-5458	184	1	doi	doi	NOUN
dpc-5458	184	2	:	:	PUNCT
dpc-5458	184	3	10.1016	10.1016	NUM
dpc-5458	184	4	/	/	SYM
dpc-5458	184	5	j.det.2024.02.001	j.det.2024.02.001	PROPN
dpc-5458	184	6	.	.	PUNCT
dpc-5458	185	1	pmid	pmid	NOUN
dpc-5458	185	2	:	:	PUNCT
dpc-5458	185	3	38796266	38796266	NUM
dpc-5458	185	4	.	.	PUNCT
dpc-5458	186	1	4	4	X
dpc-5458	186	2	.	.	X
dpc-5458	186	3	gisondi	gisondi	NOUN
dpc-5458	186	4	p	p	NOUN
dpc-5458	186	5	,	,	PUNCT
dpc-5458	186	6	del	del	PROPN
dpc-5458	186	7	giglio	giglio	PROPN
dpc-5458	186	8	m	m	PROPN
dpc-5458	186	9	,	,	PUNCT
dpc-5458	186	10	girolomoni	girolomoni	VERB
dpc-5458	186	11	g	g	NOUN
dpc-5458	186	12	treatment	treatment	NOUN
dpc-5458	186	13	approaches	approach	NOUN
dpc-5458	186	14	to	to	PART
dpc-5458	186	15	moderate	moderate	VERB
dpc-5458	186	16	to	to	ADP
dpc-5458	186	17	severe	severe	ADJ
dpc-5458	186	18	psoriasis	psoriasis	NOUN
dpc-5458	186	19	.	.	PUNCT
dpc-5458	187	1	int	int	PROPN
dpc-5458	187	2	j	j	PROPN
dpc-5458	187	3	mol	mol	ADP
dpc-5458	187	4	sci	sci	PROPN
dpc-5458	187	5	.	.	PUNCT
dpc-5458	188	1	2017;18(11):2427	2017;18(11):2427	X
dpc-5458	188	2	.	.	X
dpc-5458	188	3	doi	doi	NOUN
dpc-5458	188	4	:	:	PUNCT
dpc-5458	188	5	10.3390	10.3390	NUM
dpc-5458	188	6	/	/	SYM
dpc-5458	188	7	ijms18112427	ijms18112427	PROPN
dpc-5458	188	8	.	.	PUNCT
dpc-5458	189	1	pmid	pmid	NOUN
dpc-5458	189	2	:	:	PUNCT
dpc-5458	189	3	29144382	29144382	NUM
dpc-5458	189	4	.	.	PUNCT
dpc-5458	190	1	5	5	X
dpc-5458	190	2	.	.	X
dpc-5458	190	3	gisondi	gisondi	PROPN
dpc-5458	190	4	p	p	NOUN
dpc-5458	190	5	,	,	PUNCT
dpc-5458	190	6	fargnoli	fargnoli	PROPN
dpc-5458	190	7	mc	mc	PROPN
dpc-5458	190	8	,	,	PUNCT
dpc-5458	190	9	amerio	amerio	ADP
dpc-5458	190	10	p	p	X
dpc-5458	190	11	,	,	PUNCT
dpc-5458	190	12	et	et	PROPN
dpc-5458	190	13	al	al	PROPN
dpc-5458	190	14	.	.	PUNCT
dpc-5458	190	15	italian	italian	ADJ
dpc-5458	190	16	adaptation	adaptation	NOUN
dpc-5458	190	17	of	of	ADP
dpc-5458	190	18	euroguiderm	euroguiderm	NOUN
dpc-5458	190	19	guideline	guideline	NOUN
dpc-5458	190	20	on	on	ADP
dpc-5458	190	21	the	the	DET
dpc-5458	190	22	systemic	systemic	ADJ
dpc-5458	190	23	treatment	treatment	NOUN
dpc-5458	190	24	of	of	ADP
dpc-5458	190	25	chronic	chronic	ADJ
dpc-5458	190	26	plaque	plaque	NOUN
dpc-5458	190	27	psoriasis	psoriasis	NOUN
dpc-5458	190	28	.	.	PUNCT
dpc-5458	191	1	ital	ital	PROPN
dpc-5458	191	2	j	j	PROPN
dpc-5458	191	3	dermatol	dermatol	PROPN
dpc-5458	191	4	venerol	venerol	PROPN
dpc-5458	191	5	.	.	PUNCT
dpc-5458	192	1	2022;157	2022;157	NUM
dpc-5458	192	2	(	(	PUNCT
dpc-5458	192	3	suppl	suppl	ADJ
dpc-5458	192	4	.	.	PROPN
dpc-5458	192	5	1	1	NUM
dpc-5458	192	6	to	to	ADP
dpc-5458	192	7	no	no	NOUN
dpc-5458	192	8	.	.	PUNCT
dpc-5458	193	1	1):1	1):1	NUM
dpc-5458	193	2	-	-	SYM
dpc-5458	193	3	78	78	NUM
dpc-5458	193	4	.	.	PUNCT
dpc-5458	194	1	doi	doi	NOUN
dpc-5458	194	2	:	:	PUNCT
dpc-5458	194	3	10.23736	10.23736	NUM
dpc-5458	194	4	/	/	SYM
dpc-5458	194	5	s2784	s2784	PROPN
dpc-5458	194	6	-	-	PUNCT
dpc-5458	194	7	8671.21.07132	8671.21.07132	NUM
dpc-5458	194	8	-2	-2	NOUN
dpc-5458	194	9	.	.	PUNCT
dpc-5458	195	1	pmid	pmid	NOUN
dpc-5458	195	2	:	:	PUNCT
dpc-5458	195	3	35262308	35262308	NUM
dpc-5458	195	4	.	.	PUNCT
dpc-5458	196	1	6	6	X
dpc-5458	196	2	.	.	X
dpc-5458	196	3	puig	puig	PROPN
dpc-5458	196	4	l	l	PROPN
dpc-5458	196	5	pasi90	pasi90	PROPN
dpc-5458	196	6	response	response	NOUN
dpc-5458	196	7	:	:	PUNCT
dpc-5458	196	8	the	the	DET
dpc-5458	196	9	new	new	ADJ
dpc-5458	196	10	standard	standard	NOUN
dpc-5458	196	11	in	in	ADP
dpc-5458	196	12	therapeutic	therapeutic	ADJ
dpc-5458	196	13	efficacy	efficacy	NOUN
dpc-5458	196	14	for	for	ADP
dpc-5458	196	15	psoriasis	psoriasis	NOUN
dpc-5458	196	16	.	.	PUNCT
dpc-5458	197	1	j	j	PROPN
dpc-5458	197	2	eur	eur	PROPN
dpc-5458	197	3	acad	acad	PROPN
dpc-5458	197	4	dermatol	dermatol	NOUN
dpc-5458	197	5	venereol	venereol	NOUN
dpc-5458	197	6	.	.	PUNCT
dpc-5458	198	1	2015;29(4	2015;29(4	NUM
dpc-5458	198	2	):	):	PUNCT
dpc-5458	198	3	645	645	NUM
dpc-5458	198	4	-	-	SYM
dpc-5458	198	5	648	648	NUM
dpc-5458	198	6	.	.	PUNCT
dpc-5458	199	1	doi	doi	NOUN
dpc-5458	199	2	:	:	PUNCT
dpc-5458	199	3	10.1111	10.1111	NUM
dpc-5458	199	4	/	/	SYM
dpc-5458	199	5	jdv.12817	jdv.12817	PROPN
dpc-5458	199	6	.	.	PUNCT
dpc-5458	200	1	pmid	pmid	NOUN
dpc-5458	200	2	:	:	PUNCT
dpc-5458	200	3	25370811	25370811	NUM
dpc-5458	200	4	.	.	PUNCT
dpc-5458	201	1	7	7	X
dpc-5458	201	2	.	.	X
dpc-5458	201	3	carlin	carlin	PROPN
dpc-5458	201	4	cs	cs	PROPN
dpc-5458	201	5	,	,	PUNCT
dpc-5458	201	6	feldman	feldman	PROPN
dpc-5458	201	7	sr	sr	PROPN
dpc-5458	201	8	,	,	PUNCT
dpc-5458	201	9	krueger	krueger	PROPN
dpc-5458	201	10	jg	jg	PROPN
dpc-5458	201	11	,	,	PUNCT
dpc-5458	201	12	et	et	PROPN
dpc-5458	201	13	al	al	PROPN
dpc-5458	201	14	.	.	PUNCT
dpc-5458	202	1	a	a	DET
dpc-5458	202	2	50	50	NUM
dpc-5458	202	3	%	%	NOUN
dpc-5458	202	4	reduction	reduction	NOUN
dpc-5458	202	5	in	in	ADP
dpc-5458	202	6	the	the	DET
dpc-5458	202	7	psoriasis	psoriasis	NOUN
dpc-5458	202	8	area	area	NOUN
dpc-5458	202	9	and	and	CCONJ
dpc-5458	202	10	severity	severity	NOUN
dpc-5458	202	11	index	index	NOUN
dpc-5458	202	12	(	(	PUNCT
dpc-5458	202	13	pasi	pasi	NOUN
dpc-5458	202	14	50	50	NUM
dpc-5458	202	15	)	)	PUNCT
dpc-5458	202	16	is	be	AUX
dpc-5458	202	17	a	a	DET
dpc-5458	202	18	clinically	clinically	ADV
dpc-5458	202	19	significant	significant	ADJ
dpc-5458	202	20	endpoint	endpoint	NOUN
dpc-5458	202	21	in	in	ADP
dpc-5458	202	22	the	the	DET
dpc-5458	202	23	assessment	assessment	NOUN
dpc-5458	202	24	of	of	ADP
dpc-5458	202	25	psoriasis	psoriasis	NOUN
dpc-5458	202	26	.	.	PUNCT
dpc-5458	203	1	j	j	PROPN
dpc-5458	203	2	am	be	AUX
dpc-5458	203	3	acad	acad	ADJ
dpc-5458	203	4	dermatol	dermatol	NOUN
dpc-5458	203	5	.	.	PUNCT
dpc-5458	204	1	2004;50(6):859	2004;50(6):859	NUM
dpc-5458	204	2	-	-	PUNCT
dpc-5458	204	3	866	866	NUM
dpc-5458	204	4	.	.	PUNCT
dpc-5458	205	1	doi	doi	NOUN
dpc-5458	205	2	:	:	PUNCT
dpc-5458	205	3	10.1016	10.1016	NUM
dpc-5458	205	4	/	/	SYM
dpc-5458	205	5	j	j	PROPN
dpc-5458	205	6	.jaad.2003.09.014	.jaad.2003.09.014	PUNCT
dpc-5458	205	7	.	.	PUNCT
dpc-5458	206	1	pmid	pmid	NOUN
dpc-5458	206	2	:	:	PUNCT
dpc-5458	206	3	15153885	15153885	NUM
dpc-5458	206	4	.	.	PUNCT
dpc-5458	207	1	8	8	X
dpc-5458	207	2	.	.	X
dpc-5458	207	3	abrouk	abrouk	PROPN
dpc-5458	207	4	m	m	PROPN
dpc-5458	207	5	,	,	PUNCT
dpc-5458	207	6	nakamura	nakamura	PROPN
dpc-5458	207	7	m	m	PROPN
dpc-5458	207	8	,	,	PUNCT
dpc-5458	207	9	zhu	zhu	PROPN
dpc-5458	207	10	th	th	PROPN
dpc-5458	207	11	,	,	PUNCT
dpc-5458	207	12	et	et	PROPN
dpc-5458	207	13	al	al	PROPN
dpc-5458	207	14	.	.	PUNCT
dpc-5458	208	1	the	the	DET
dpc-5458	208	2	impact	impact	NOUN
dpc-5458	208	3	of	of	ADP
dpc-5458	208	4	pasi	pasi	NOUN
dpc-5458	208	5	75	75	NUM
dpc-5458	208	6	and	and	CCONJ
dpc-5458	208	7	pasi	pasi	VERB
dpc-5458	208	8	90	90	NUM
dpc-5458	208	9	on	on	ADP
dpc-5458	208	10	quality	quality	NOUN
dpc-5458	208	11	of	of	ADP
dpc-5458	208	12	life	life	NOUN
dpc-5458	208	13	in	in	ADP
dpc-5458	208	14	moderate	moderate	ADJ
dpc-5458	208	15	to	to	ADP
dpc-5458	208	16	severe	severe	ADJ
dpc-5458	208	17	psoriasis	psoriasis	NOUN
dpc-5458	208	18	patients	patient	NOUN
dpc-5458	208	19	.	.	PUNCT
dpc-5458	209	1	j	j	PROPN
dpc-5458	209	2	dermatolog	dermatolog	PROPN
dpc-5458	209	3	treat	treat	NOUN
dpc-5458	209	4	.	.	PUNCT
dpc-5458	210	1	2017;28(6):488	2017;28(6):488	NUM
dpc-5458	210	2	-	-	SYM
dpc-5458	210	3	491	491	NUM
dpc-5458	210	4	.	.	PUNCT
dpc-5458	211	1	doi	doi	NOUN
dpc-5458	211	2	:	:	PUNCT
dpc-5458	211	3	10.1080/09546634.2016.1278198	10.1080/09546634.2016.1278198	NUM
dpc-5458	211	4	.	.	PUNCT
dpc-5458	212	1	pmid	pmid	NOUN
dpc-5458	212	2	:	:	PUNCT
dpc-5458	212	3	28042711	28042711	NUM
dpc-5458	212	4	.	.	PUNCT
dpc-5458	213	1	9	9	X
dpc-5458	213	2	.	.	X
dpc-5458	213	3	goldman	goldman	PROPN
dpc-5458	213	4	md	md	PROPN
dpc-5458	213	5	,	,	PUNCT
dpc-5458	213	6	dwyer	dwyer	PROPN
dpc-5458	213	7	l	l	PROPN
dpc-5458	213	8	,	,	PUNCT
dpc-5458	213	9	coleman	coleman	PROPN
dpc-5458	213	10	r	r	PROPN
dpc-5458	213	11	,	,	PUNCT
dpc-5458	213	12	et	et	PROPN
dpc-5458	213	13	al	al	PROPN
dpc-5458	213	14	.	.	PUNCT
dpc-5458	213	15	patient	patient	NOUN
dpc-5458	213	16	-	-	PUNCT
dpc-5458	213	17	specific	specific	ADJ
dpc-5458	213	18	factors	factor	NOUN
dpc-5458	213	19	modulate	modulate	VERB
dpc-5458	213	20	leukocyte	leukocyte	ADJ
dpc-5458	213	21	response	response	NOUN
dpc-5458	213	22	in	in	ADP
dpc-5458	213	23	dimethyl	dimethyl	PROPN
dpc-5458	213	24	fumarate	fumarate	NOUN
dpc-5458	213	25	treated	treat	VERB
dpc-5458	213	26	ms	ms	ADJ
dpc-5458	213	27	patients	patient	NOUN
dpc-5458	213	28	.	.	PUNCT
dpc-5458	214	1	plos	plos	PROPN
dpc-5458	214	2	one	one	NUM
dpc-5458	214	3	.	.	PUNCT
dpc-5458	215	1	2020;15	2020;15	NUM
dpc-5458	215	2	:	:	PUNCT
dpc-5458	215	3	e0228617	e0228617	ADJ
dpc-5458	215	4	.	.	PUNCT
dpc-5458	215	5	doi	doi	NOUN
dpc-5458	215	6	:	:	PUNCT
dpc-5458	215	7	10.1371	10.1371	NUM
dpc-5458	215	8	/journal.pone.0228617	/journal.pone.0228617	X
dpc-5458	215	9	.	.	PUNCT
dpc-5458	216	1	pmid	pmid	NOUN
dpc-5458	216	2	:	:	PUNCT
dpc-5458	216	3	32045436	32045436	NUM
dpc-5458	216	4	.	.	PUNCT
dpc-5458	217	1	10	10	NUM
dpc-5458	217	2	.	.	PUNCT
dpc-5458	218	1	van	van	PROPN
dpc-5458	218	2	huizen	huizen	PROPN
dpc-5458	218	3	am	am	PROPN
dpc-5458	218	4	,	,	PUNCT
dpc-5458	218	5	menting	mente	VERB
dpc-5458	218	6	sp	sp	NOUN
dpc-5458	218	7	,	,	PUNCT
dpc-5458	218	8	gyulai	gyulai	NOUN
dpc-5458	218	9	r	r	PROPN
dpc-5458	218	10	,	,	PUNCT
dpc-5458	218	11	et	et	PROPN
dpc-5458	218	12	al	al	PROPN
dpc-5458	218	13	.	.	PROPN
dpc-5458	219	1	international	international	ADJ
dpc-5458	219	2	edelphi	edelphi	PROPN
dpc-5458	219	3	study	study	NOUN
dpc-5458	219	4	to	to	PART
dpc-5458	219	5	reach	reach	VERB
dpc-5458	219	6	consensus	consensus	NOUN
dpc-5458	219	7	on	on	ADP
dpc-5458	219	8	the	the	DET
dpc-5458	219	9	methotrexate	methotrexate	NOUN
dpc-5458	219	10	dosing	dose	VERB
dpc-5458	219	11	regimen	regiman	NOUN
dpc-5458	219	12	in	in	ADP
dpc-5458	219	13	patients	patient	NOUN
dpc-5458	219	14	with	with	ADP
dpc-5458	219	15	psoriasis	psoriasis	NOUN
dpc-5458	219	16	.	.	PUNCT
dpc-5458	220	1	jama	jama	PROPN
dpc-5458	220	2	dermatol	dermatol	NOUN
dpc-5458	220	3	.	.	PUNCT
dpc-5458	221	1	2022;158(5):561	2022;158(5):561	NUM
dpc-5458	221	2	-	-	PUNCT
dpc-5458	221	3	572	572	NUM
dpc-5458	221	4	.	.	PUNCT
dpc-5458	221	5	doi	doi	NOUN
dpc-5458	221	6	:	:	PUNCT
dpc-5458	221	7	10.1001	10.1001	NUM
dpc-5458	221	8	/	/	SYM
dpc-5458	221	9	jamadermatol.2022.0434	jamadermatol.2022.0434	PROPN
dpc-5458	221	10	.	.	PUNCT
dpc-5458	222	1	pmid	pmid	NOUN
dpc-5458	222	2	:	:	PUNCT
dpc-5458	222	3	35353175	35353175	NUM
dpc-5458	222	4	.	.	PUNCT
dpc-5458	223	1	11	11	NUM
dpc-5458	223	2	.	.	PUNCT
dpc-5458	224	1	warren	warren	PROPN
dpc-5458	224	2	rb	rb	PROPN
dpc-5458	224	3	,	,	PUNCT
dpc-5458	224	4	weatherhead	weatherhead	PROPN
dpc-5458	224	5	sc	sc	PROPN
dpc-5458	224	6	,	,	PUNCT
dpc-5458	224	7	smith	smith	PROPN
dpc-5458	224	8	ch	ch	PROPN
dpc-5458	224	9	,	,	PUNCT
dpc-5458	224	10	et	et	PROPN
dpc-5458	224	11	al	al	PROPN
dpc-5458	224	12	.	.	PROPN
dpc-5458	225	1	british	british	PROPN
dpc-5458	225	2	association	association	PROPN
dpc-5458	225	3	of	of	ADP
dpc-5458	225	4	dermatologists	dermatologists	PROPN
dpc-5458	225	5	'	'	PART
dpc-5458	225	6	guidelines	guideline	NOUN
dpc-5458	225	7	for	for	ADP
dpc-5458	225	8	the	the	DET
dpc-5458	225	9	safe	safe	ADJ
dpc-5458	225	10	and	and	CCONJ
dpc-5458	225	11	effective	effective	ADJ
dpc-5458	225	12	prescribing	prescribing	NOUN
dpc-5458	225	13	of	of	ADP
dpc-5458	225	14	methotrexate	methotrexate	NOUN
dpc-5458	225	15	for	for	ADP
dpc-5458	225	16	skin	skin	NOUN
dpc-5458	225	17	disease	disease	NOUN
dpc-5458	225	18	2016	2016	NUM
dpc-5458	225	19	.	.	PUNCT
dpc-5458	226	1	br	br	PROPN
dpc-5458	226	2	j	j	PROPN
dpc-5458	226	3	dermatol	dermatol	NOUN
dpc-5458	226	4	.	.	PUNCT
dpc-5458	227	1	2016;175(1):23	2016;175(1):23	NUM
dpc-5458	227	2	-	-	SYM
dpc-5458	227	3	44	44	NUM
dpc-5458	227	4	.	.	PUNCT
dpc-5458	228	1	doi	doi	NOUN
dpc-5458	228	2	:	:	PUNCT
dpc-5458	228	3	10.1111	10.1111	NUM
dpc-5458	228	4	/	/	SYM
dpc-5458	228	5	bjd.14816	bjd.14816	PROPN
dpc-5458	228	6	.	.	PUNCT
dpc-5458	229	1	pmid	pmid	NOUN
dpc-5458	229	2	:	:	PUNCT
dpc-5458	229	3	27484275	27484275	NUM
dpc-5458	229	4	.	.	PUNCT
dpc-5458	230	1	12	12	NUM
dpc-5458	230	2	.	.	PUNCT
dpc-5458	231	1	sbidian	sbidian	PROPN
dpc-5458	231	2	e	e	PROPN
dpc-5458	231	3	,	,	PUNCT
dpc-5458	231	4	chaimani	chaimani	X
dpc-5458	231	5	a	a	PRON
dpc-5458	231	6	,	,	PUNCT
dpc-5458	231	7	garcia	garcia	PROPN
dpc-5458	231	8	-	-	PUNCT
dpc-5458	231	9	doval	doval	PROPN
dpc-5458	232	1	i	i	PROPN
dpc-5458	232	2	,	,	PUNCT
dpc-5458	232	3	et	et	PROPN
dpc-5458	232	4	al	al	PROPN
dpc-5458	232	5	.	.	PUNCT
dpc-5458	233	1	systemic	systemic	ADJ
dpc-5458	233	2	pharmacological	pharmacological	ADJ
dpc-5458	233	3	treatments	treatment	NOUN
dpc-5458	233	4	for	for	ADP
dpc-5458	233	5	chronic	chronic	ADJ
dpc-5458	233	6	plaque	plaque	NOUN
dpc-5458	233	7	psoriasis	psoriasis	NOUN
dpc-5458	233	8	:	:	PUNCT
dpc-5458	233	9	a	a	DET
dpc-5458	233	10	network	network	NOUN
dpc-5458	233	11	meta	meta	NOUN
dpc-5458	233	12	analysis	analysis	NOUN
dpc-5458	233	13	.	.	PUNCT
dpc-5458	234	1	cochrane	cochrane	NOUN
dpc-5458	234	2	database	database	PROPN
dpc-5458	234	3	syst	syst	PROPN
dpc-5458	234	4	rev	rev	PROPN
dpc-5458	234	5	.	.	PUNCT
dpc-5458	235	1	2022;5(5):cd011535	2022;5(5):cd011535	NUM
dpc-5458	235	2	.	.	PUNCT
dpc-5458	236	1	doi	doi	NOUN
dpc-5458	236	2	:	:	PUNCT
dpc-5458	237	1	10.1002/14651858.cd011535.pub5	10.1002/14651858.cd011535.pub5	NUM
dpc-5458	237	2	.	.	PUNCT
dpc-5458	238	1	pmid	pmid	NOUN
dpc-5458	238	2	:	:	PUNCT
dpc-5458	238	3	35603936	35603936	NUM
dpc-5458	238	4	.	.	PUNCT
dpc-5458	239	1	13	13	NUM
dpc-5458	239	2	.	.	PUNCT
dpc-5458	240	1	maza	maza	PROPN
dpc-5458	240	2	a	a	X
dpc-5458	240	3	,	,	PUNCT
dpc-5458	240	4	montaudié	montaudié	ADJ
dpc-5458	240	5	h	h	NOUN
dpc-5458	240	6	,	,	PUNCT
dpc-5458	240	7	sbidian	sbidian	PROPN
dpc-5458	240	8	e	e	PROPN
dpc-5458	240	9	,	,	PUNCT
dpc-5458	240	10	et	et	PROPN
dpc-5458	240	11	al	al	PROPN
dpc-5458	240	12	.	.	PROPN
dpc-5458	240	13	oral	oral	ADJ
dpc-5458	240	14	cyclosporin	cyclosporin	NOUN
dpc-5458	240	15	in	in	ADP
dpc-5458	240	16	psoriasis	psoriasis	NOUN
dpc-5458	240	17	:	:	PUNCT
dpc-5458	240	18	a	a	DET
dpc-5458	240	19	systematic	systematic	ADJ
dpc-5458	240	20	review	review	NOUN
dpc-5458	240	21	on	on	ADP
dpc-5458	240	22	treatment	treatment	NOUN
dpc-5458	240	23	modalities	modality	NOUN
dpc-5458	240	24	,	,	PUNCT
dpc-5458	240	25	risk	risk	NOUN
dpc-5458	240	26	of	of	ADP
dpc-5458	240	27	kidney	kidney	NOUN
dpc-5458	240	28	toxicity	toxicity	NOUN
dpc-5458	240	29	and	and	CCONJ
dpc-5458	240	30	evidence	evidence	NOUN
dpc-5458	240	31	for	for	ADP
dpc-5458	240	32	use	use	NOUN
dpc-5458	240	33	in	in	ADP
dpc-5458	240	34	non	non	ADJ
dpc-5458	240	35	-	-	ADJ
dpc-5458	240	36	plaque	plaque	ADJ
dpc-5458	240	37	psoriasis	psoriasis	NOUN
dpc-5458	240	38	.	.	PUNCT
dpc-5458	241	1	j	j	PROPN
dpc-5458	241	2	eur	eur	PROPN
dpc-5458	241	3	acad	acad	PROPN
dpc-5458	241	4	dermatol	dermatol	NOUN
dpc-5458	241	5	venereol	venereol	NOUN
dpc-5458	241	6	.	.	PUNCT
dpc-5458	242	1	2011;25	2011;25	NUM
dpc-5458	242	2	suppl	suppl	PROPN
dpc-5458	242	3	2:19	2:19	NUM
dpc-5458	242	4	-	-	SYM
dpc-5458	242	5	27	27	NUM
dpc-5458	242	6	.	.	PUNCT
dpc-5458	243	1	doi	doi	NOUN
dpc-5458	243	2	:	:	PUNCT
dpc-5458	243	3	10.1111	10.1111	NUM
dpc-5458	243	4	/	/	SYM
dpc-5458	243	5	j.1468	j.1468	NOUN
dpc-5458	243	6	-	-	PUNCT
dpc-5458	243	7	3083.2011.03992.x	3083.2011.03992.x	NUM
dpc-5458	243	8	.	.	PUNCT
dpc-5458	244	1	pmid	pmid	NOUN
dpc-5458	244	2	:	:	PUNCT
dpc-5458	244	3	21388455	21388455	NUM
dpc-5458	244	4	.	.	PUNCT
dpc-5458	245	1	14	14	NUM
dpc-5458	245	2	.	.	PUNCT
dpc-5458	246	1	dogra	dogra	PROPN
dpc-5458	246	2	s	s	PROPN
dpc-5458	246	3	,	,	PUNCT
dpc-5458	246	4	yadav	yadav	PROPN
dpc-5458	246	5	s.	s.	PROPN
dpc-5458	246	6	acitretin	acitretin	PROPN
dpc-5458	246	7	in	in	ADP
dpc-5458	246	8	psoriasis	psoriasis	NOUN
dpc-5458	246	9	:	:	PUNCT
dpc-5458	246	10	an	an	DET
dpc-5458	246	11	evolving	evolve	VERB
dpc-5458	246	12	scenario	scenario	NOUN
dpc-5458	246	13	.	.	PUNCT
dpc-5458	247	1	int	int	NOUN
dpc-5458	247	2	j	j	PROPN
dpc-5458	247	3	dermatol	dermatol	NOUN
dpc-5458	247	4	.	.	PUNCT
dpc-5458	248	1	2014;53(5):525	2014;53(5):525	PROPN
dpc-5458	248	2	-	-	SYM
dpc-5458	248	3	38	38	NUM
dpc-5458	248	4	.	.	PUNCT
dpc-5458	249	1	doi	doi	NOUN
dpc-5458	249	2	:	:	PUNCT
dpc-5458	249	3	10.1111	10.1111	NUM
dpc-5458	249	4	/	/	SYM
dpc-5458	249	5	ijd.12365	ijd.12365	PROPN
dpc-5458	249	6	.	.	PUNCT
dpc-5458	250	1	pmid	pmid	NOUN
dpc-5458	250	2	:	:	PUNCT
dpc-5458	250	3	24601982	24601982	NUM
dpc-5458	250	4	.	.	PUNCT
dpc-5458	251	1	15	15	X
dpc-5458	251	2	.	.	X
dpc-5458	251	3	carretero	carretero	PROPN
dpc-5458	251	4	g	g	PROPN
dpc-5458	251	5	,	,	PUNCT
dpc-5458	251	6	ribera	ribera	PROPN
dpc-5458	251	7	m	m	PROPN
dpc-5458	251	8	,	,	PUNCT
dpc-5458	251	9	belinchón	belinchón	PROPN
dpc-5458	251	10	i	i	PROPN
dpc-5458	251	11	,	,	PUNCT
dpc-5458	251	12	et	et	PROPN
dpc-5458	251	13	al	al	PROPN
dpc-5458	251	14	.	.	PROPN
dpc-5458	251	15	;	;	PUNCT
dpc-5458	251	16	psoriasis	psoriasis	NOUN
dpc-5458	251	17	group	group	NOUN
dpc-5458	251	18	of	of	ADP
dpc-5458	251	19	the	the	DET
dpc-5458	251	20	aedv	aedv	NOUN
dpc-5458	251	21	.	.	PUNCT
dpc-5458	252	1	guidelines	guideline	NOUN
dpc-5458	252	2	for	for	ADP
dpc-5458	252	3	the	the	DET
dpc-5458	252	4	use	use	NOUN
dpc-5458	252	5	of	of	ADP
dpc-5458	252	6	acitretin	acitretin	NOUN
dpc-5458	252	7	in	in	ADP
dpc-5458	252	8	psoriasis	psoriasis	NOUN
dpc-5458	252	9	.	.	PUNCT
dpc-5458	253	1	psoriasis	psoriasis	NOUN
dpc-5458	253	2	group	group	NOUN
dpc-5458	253	3	of	of	ADP
dpc-5458	253	4	the	the	DET
dpc-5458	253	5	spanish	spanish	ADJ
dpc-5458	253	6	academy	academy	NOUN
dpc-5458	253	7	of	of	ADP
dpc-5458	253	8	dermatology	dermatology	NOUN
dpc-5458	253	9	and	and	CCONJ
dpc-5458	253	10	venereology	venereology	NOUN
dpc-5458	253	11	.	.	PUNCT
dpc-5458	254	1	actas	actas	PROPN
dpc-5458	254	2	dermosifiliogr	dermosifiliogr	NOUN
dpc-5458	254	3	.	.	PUNCT
dpc-5458	255	1	2013;104(7):598	2013;104(7):598	NUM
dpc-5458	255	2	-	-	SYM
dpc-5458	255	3	616	616	NUM
dpc-5458	255	4	.	.	PUNCT
dpc-5458	256	1	doi	doi	NOUN
dpc-5458	256	2	:	:	PUNCT
dpc-5458	256	3	10.1016	10.1016	NUM
dpc-5458	256	4	/	/	SYM
dpc-5458	256	5	j.adengl.2013.01.001	j.adengl.2013.01.001	PROPN
dpc-5458	256	6	.	.	PUNCT
dpc-5458	257	1	pmid	pmid	NOUN
dpc-5458	257	2	:	:	PUNCT
dpc-5458	257	3	23891453	23891453	NUM
dpc-5458	257	4	.	.	PUNCT
dpc-5458	258	1	16	16	NUM
dpc-5458	258	2	.	.	PUNCT
dpc-5458	258	3	ormerod	ormerod	NOUN
dpc-5458	258	4	ad	ad	NOUN
dpc-5458	258	5	,	,	PUNCT
dpc-5458	258	6	campalani	campalani	NOUN
dpc-5458	258	7	e	e	NOUN
dpc-5458	258	8	,	,	PUNCT
dpc-5458	258	9	goodfield	goodfield	PROPN
dpc-5458	258	10	mj	mj	PROPN
dpc-5458	258	11	;	;	PUNCT
dpc-5458	258	12	bad	bad	ADJ
dpc-5458	258	13	clinical	clinical	ADJ
dpc-5458	258	14	standards	standard	NOUN
dpc-5458	258	15	unit	unit	NOUN
dpc-5458	258	16	.	.	PUNCT
dpc-5458	259	1	british	british	PROPN
dpc-5458	259	2	association	association	PROPN
dpc-5458	259	3	of	of	ADP
dpc-5458	259	4	dermatologists	dermatologists	PROPN
dpc-5458	259	5	guidelines	guideline	NOUN
dpc-5458	259	6	on	on	ADP
dpc-5458	259	7	the	the	DET
dpc-5458	259	8	efficacy	efficacy	NOUN
dpc-5458	259	9	and	and	CCONJ
dpc-5458	259	10	use	use	NOUN
dpc-5458	259	11	of	of	ADP
dpc-5458	259	12	acitretin	acitretin	NOUN
dpc-5458	259	13	in	in	ADP
dpc-5458	259	14	dermatology	dermatology	NOUN
dpc-5458	259	15	.	.	PUNCT
dpc-5458	260	1	br	br	PROPN
dpc-5458	260	2	j	j	PROPN
dpc-5458	260	3	dermatol	dermatol	NOUN
dpc-5458	260	4	.	.	PUNCT
dpc-5458	261	1	2010;162(5):952	2010;162(5):952	NOUN
dpc-5458	261	2	-	-	SYM
dpc-5458	261	3	63	63	NUM
dpc-5458	261	4	.	.	PUNCT
dpc-5458	262	1	doi	doi	NOUN
dpc-5458	262	2	:	:	PUNCT
dpc-5458	262	3	10.1111	10.1111	NUM
dpc-5458	262	4	/	/	SYM
dpc-5458	262	5	j.1365	j.1365	NOUN
dpc-5458	262	6	-	-	PUNCT
dpc-5458	262	7	2133.2010.09755.x	2133.2010.09755.x	NUM
dpc-5458	262	8	.	.	PUNCT
dpc-5458	263	1	pmid	pmid	NOUN
dpc-5458	263	2	:	:	PUNCT
dpc-5458	263	3	20423353	20423353	NUM
dpc-5458	263	4	.	.	PUNCT
dpc-5458	264	1	17	17	NUM
dpc-5458	264	2	.	.	PUNCT
dpc-5458	265	1	european	european	PROPN
dpc-5458	265	2	medicines	medicine	NOUN
dpc-5458	265	3	agency	agency	NOUN
dpc-5458	265	4	.	.	PUNCT
dpc-5458	266	1	skilarence	skilarence	PROPN
dpc-5458	266	2	,	,	PUNCT
dpc-5458	266	3	inn	inn	PROPN
dpc-5458	266	4	-	-	PUNCT
dpc-5458	266	5	dimethyl	dimethyl	NOUN
dpc-5458	266	6	fumarate	fumarate	NOUN
dpc-5458	266	7	:	:	PUNCT
dpc-5458	266	8	summary	summary	NOUN
dpc-5458	266	9	of	of	ADP
dpc-5458	266	10	product	product	NOUN
dpc-5458	266	11	characteristics	characteristic	NOUN
dpc-5458	266	12	;	;	PUNCT
dpc-5458	266	13	2017	2017	NUM
dpc-5458	266	14	.	.	PUNCT
dpc-5458	267	1	available	available	ADJ
dpc-5458	267	2	from	from	ADP
dpc-5458	267	3	:	:	PUNCT
dpc-5458	267	4	https://www.ema.europa.eu/en/medicines/human/epar/skilarence#product-information-section	https://www.ema.europa.eu/en/medicines/human/epar/skilarence#product-information-section	PROPN
dpc-5458	267	5	accessed	access	VERB
dpc-5458	267	6	:	:	PUNCT
dpc-5458	267	7	12	12	NUM
dpc-5458	267	8	may	may	PROPN
dpc-5458	267	9	2022	2022	NUM
dpc-5458	267	10	.	.	PUNCT
dpc-5458	268	1	18	18	NUM
dpc-5458	268	2	.	.	PUNCT
dpc-5458	269	1	brück	brück	PROPN
dpc-5458	269	2	j	j	PROPN
dpc-5458	269	3	,	,	PUNCT
dpc-5458	269	4	dringen	dringen	PROPN
dpc-5458	269	5	r	r	NOUN
dpc-5458	269	6	,	,	PUNCT
dpc-5458	269	7	amasuno	amasuno	ADV
dpc-5458	269	8	a	a	PRON
dpc-5458	269	9	,	,	PUNCT
dpc-5458	269	10	pau	pau	PROPN
dpc-5458	269	11	-	-	PUNCT
dpc-5458	269	12	charles	charles	PROPN
dpc-5458	269	13	i	i	PROPN
dpc-5458	269	14	,	,	PUNCT
dpc-5458	269	15	ghoreschi	ghoreschi	PROPN
dpc-5458	269	16	k.	k.	PROPN
dpc-5458	270	1	a	a	DET
dpc-5458	270	2	review	review	NOUN
dpc-5458	270	3	of	of	ADP
dpc-5458	270	4	the	the	DET
dpc-5458	270	5	mechanisms	mechanism	NOUN
dpc-5458	270	6	of	of	ADP
dpc-5458	270	7	action	action	NOUN
dpc-5458	270	8	of	of	ADP
dpc-5458	270	9	dimethylfumarate	dimethylfumarate	NOUN
dpc-5458	270	10	in	in	ADP
dpc-5458	270	11	the	the	DET
dpc-5458	270	12	treatment	treatment	NOUN
dpc-5458	270	13	of	of	ADP
dpc-5458	270	14	psoriasis	psoriasis	NOUN
dpc-5458	270	15	.	.	PUNCT
dpc-5458	271	1	exp	exp	NOUN
dpc-5458	271	2	dermatol	dermatol	NOUN
dpc-5458	271	3	.	.	PUNCT
dpc-5458	272	1	2018;27:611	2018;27:611	NUM
dpc-5458	272	2	-	-	PUNCT
dpc-5458	272	3	624	624	NUM
dpc-5458	272	4	.	.	PUNCT
dpc-5458	273	1	doi	doi	NOUN
dpc-5458	273	2	:	:	PUNCT
dpc-5458	273	3	10.1111	10.1111	NUM
dpc-5458	273	4	/	/	SYM
dpc-5458	273	5	exd.13548	exd.13548	NOUN
dpc-5458	273	6	.	.	PUNCT
dpc-5458	274	1	pmid	pmid	NOUN
dpc-5458	274	2	:	:	PUNCT
dpc-5458	274	3	29603404	29603404	NUM
dpc-5458	274	4	.	.	PUNCT
dpc-5458	275	1	19	19	NUM
dpc-5458	275	2	.	.	X
dpc-5458	275	3	pellacani	pellacani	PROPN
dpc-5458	275	4	g	g	PROPN
dpc-5458	275	5	,	,	PUNCT
dpc-5458	275	6	bigi	bigi	PROPN
dpc-5458	275	7	l	l	PROPN
dpc-5458	275	8	,	,	PUNCT
dpc-5458	275	9	parodi	parodi	PROPN
dpc-5458	275	10	a	a	PRON
dpc-5458	275	11	,	,	PUNCT
dpc-5458	275	12	et	et	PROPN
dpc-5458	275	13	al	al	PROPN
dpc-5458	275	14	.	.	PROPN
dpc-5458	275	15	efficacy	efficacy	NOUN
dpc-5458	275	16	and	and	CCONJ
dpc-5458	275	17	safety	safety	NOUN
dpc-5458	275	18	of	of	ADP
dpc-5458	275	19	dimethyl	dimethyl	NOUN
dpc-5458	275	20	fumarate	fumarate	NOUN
dpc-5458	275	21	in	in	ADP
dpc-5458	275	22	patients	patient	NOUN
dpc-5458	275	23	with	with	ADP
dpc-5458	275	24	moderate	moderate	ADJ
dpc-5458	275	25	-	-	PUNCT
dpc-5458	275	26	to	to	ADP
dpc-5458	275	27	-	-	PUNCT
dpc-5458	275	28	severe	severe	ADJ
dpc-5458	275	29	plaque	plaque	NOUN
dpc-5458	275	30	psoriasis	psoriasis	NOUN
dpc-5458	275	31	:	:	PUNCT
dpc-5458	275	32	dimeskin-2	dimeskin-2	NUM
dpc-5458	275	33	,	,	PUNCT
dpc-5458	275	34	a	a	DET
dpc-5458	275	35	multicentre	multicentre	ADJ
dpc-5458	275	36	single	single	ADJ
dpc-5458	275	37	-	-	PUNCT
dpc-5458	275	38	arm	arm	NOUN
dpc-5458	275	39	phase	phase	NOUN
dpc-5458	275	40	iiib	iiib	NOUN
dpc-5458	275	41	study	study	NOUN
dpc-5458	275	42	.	.	PUNCT
dpc-5458	276	1	j	j	PROPN
dpc-5458	276	2	clin	clin	PROPN
dpc-5458	276	3	med	me	VERB
dpc-5458	276	4	.	.	PUNCT
dpc-5458	277	1	2022;11(16):4778.doi	2022;11(16):4778.doi	NUM
dpc-5458	277	2	:	:	PUNCT
dpc-5458	277	3	10.3390	10.3390	NUM
dpc-5458	277	4	/	/	SYM
dpc-5458	277	5	jcm11164778	jcm11164778	NOUN
dpc-5458	277	6	.	.	PUNCT
dpc-5458	278	1	pmid	pmid	NOUN
dpc-5458	278	2	:	:	PUNCT
dpc-5458	278	3	36013015	36013015	NUM
dpc-5458	278	4	.	.	PUNCT
dpc-5458	279	1	20	20	NUM
dpc-5458	279	2	.	.	PUNCT
dpc-5458	280	1	mrowietz	mrowietz	PROPN
dpc-5458	280	2	u	u	NOUN
dpc-5458	280	3	,	,	PUNCT
dpc-5458	280	4	szepietowski	szepietowski	PROPN
dpc-5458	280	5	jc	jc	PROPN
dpc-5458	280	6	,	,	PUNCT
dpc-5458	280	7	loewe	loewe	PROPN
dpc-5458	280	8	r	r	PROPN
dpc-5458	280	9	,	,	PUNCT
dpc-5458	280	10	et	et	PROPN
dpc-5458	280	11	al	al	PROPN
dpc-5458	280	12	.	.	PROPN
dpc-5458	280	13	efficacy	efficacy	NOUN
dpc-5458	280	14	and	and	CCONJ
dpc-5458	280	15	safety	safety	NOUN
dpc-5458	280	16	of	of	ADP
dpc-5458	280	17	las41008	las41008	NOUN
dpc-5458	280	18	(	(	PUNCT
dpc-5458	280	19	dimethyl	dimethyl	NOUN
dpc-5458	280	20	fumarate	fumarate	NOUN
dpc-5458	280	21	)	)	PUNCT
dpc-5458	280	22	in	in	ADP
dpc-5458	280	23	adults	adult	NOUN
dpc-5458	280	24	with	with	ADP
dpc-5458	280	25	moderate	moderate	ADJ
dpc-5458	280	26	-	-	PUNCT
dpc-5458	280	27	to	to	ADP
dpc-5458	280	28	-	-	PUNCT
dpc-5458	280	29	severe	severe	ADJ
dpc-5458	280	30	chronic	chronic	ADJ
dpc-5458	280	31	plaque	plaque	NOUN
dpc-5458	280	32	psoriasis	psoriasis	NOUN
dpc-5458	280	33	:	:	PUNCT
dpc-5458	280	34	a	a	PRON
dpc-5458	280	35	randomized	randomized	ADJ
dpc-5458	280	36	,	,	PUNCT
dpc-5458	280	37	double	double	ADJ
dpc-5458	280	38	-	-	PUNCT
dpc-5458	280	39	blind	blind	ADJ
dpc-5458	280	40	,	,	PUNCT
dpc-5458	280	41	fumaderm	fumaderm	NOUN
dpc-5458	280	42	®	®	NOUN
dpc-5458	280	43	and	and	CCONJ
dpc-5458	280	44	placebo	placebo	NOUN
dpc-5458	280	45	-	-	PUNCT
dpc-5458	280	46	controlled	control	VERB
dpc-5458	280	47	trial	trial	NOUN
dpc-5458	280	48	(	(	PUNCT
dpc-5458	280	49	bridge	bridge	NOUN
dpc-5458	280	50	)	)	PUNCT
dpc-5458	280	51	.	.	PUNCT
dpc-5458	281	1	br	br	PROPN
dpc-5458	281	2	j	j	PROPN
dpc-5458	281	3	dermatol	dermatol	NOUN
dpc-5458	281	4	.	.	PUNCT
dpc-5458	282	1	2017;176(3):615	2017;176(3):615	NUM
dpc-5458	282	2	-	-	SYM
dpc-5458	282	3	623	623	NUM
dpc-5458	282	4	.	.	PUNCT
dpc-5458	283	1	doi	doi	NOUN
dpc-5458	283	2	:	:	PUNCT
dpc-5458	283	3	10.1111	10.1111	NUM
dpc-5458	283	4	/	/	SYM
dpc-5458	283	5	bjd.14947	bjd.14947	NOUN
dpc-5458	283	6	.	.	PUNCT
dpc-5458	284	1	pmid	pmid	NOUN
dpc-5458	284	2	:	:	PUNCT
dpc-5458	284	3	27515097	27515097	NUM
dpc-5458	284	4	.	.	PUNCT
dpc-5458	285	1	21	21	NUM
dpc-5458	285	2	.	.	PUNCT
dpc-5458	286	1	corazza	corazza	PROPN
dpc-5458	286	2	m	m	PROPN
dpc-5458	286	3	,	,	PUNCT
dpc-5458	286	4	odorici	odorici	VERB
dpc-5458	286	5	g	g	PROPN
dpc-5458	286	6	,	,	PUNCT
dpc-5458	286	7	conti	conti	PROPN
dpc-5458	286	8	a	a	X
dpc-5458	286	9	,	,	PUNCT
dpc-5458	286	10	et	et	PROPN
dpc-5458	286	11	al	al	PROPN
dpc-5458	286	12	.	.	PROPN
dpc-5458	286	13	dimethyl	dimethyl	PROPN
dpc-5458	286	14	fumarate	fumarate	ADJ
dpc-5458	286	15	treatment	treatment	NOUN
dpc-5458	286	16	for	for	ADP
dpc-5458	286	17	psoriasis	psoriasis	NOUN
dpc-5458	286	18	in	in	ADP
dpc-5458	286	19	a	a	DET
dpc-5458	286	20	real	real	ADJ
dpc-5458	286	21	-	-	PUNCT
dpc-5458	286	22	life	life	NOUN
dpc-5458	286	23	setting	setting	NOUN
dpc-5458	286	24	:	:	PUNCT
dpc-5458	286	25	a	a	DET
dpc-5458	286	26	multicentric	multicentric	ADJ
dpc-5458	286	27	retrospective	retrospective	ADJ
dpc-5458	286	28	study	study	NOUN
dpc-5458	286	29	.	.	PUNCT
dpc-5458	287	1	dermatol	dermatol	NOUN
dpc-5458	287	2	ther	ther	ADV
dpc-5458	287	3	.	.	PUNCT
dpc-5458	288	1	2021;34(5):e15066	2021;34(5):e15066	X
dpc-5458	288	2	.	.	PUNCT
dpc-5458	288	3	doi	doi	NOUN
dpc-5458	288	4	:	:	PUNCT
dpc-5458	288	5	10.1111/	10.1111/	NUM
dpc-5458	288	6	dth.15066	dth.15066	NUM
dpc-5458	288	7	.	.	PUNCT
dpc-5458	289	1	pmid	pmid	NOUN
dpc-5458	289	2	:	:	PUNCT
dpc-5458	289	3	34291547	34291547	NUM
dpc-5458	289	4	.	.	PUNCT
dpc-5458	290	1	22	22	NUM
dpc-5458	290	2	.	.	PUNCT
dpc-5458	291	1	tapia	tapia	PROPN
dpc-5458	291	2	c	c	PROPN
dpc-5458	291	3	,	,	PUNCT
dpc-5458	291	4	nessel	nessel	PROPN
dpc-5458	291	5	ta	ta	PROPN
dpc-5458	291	6	,	,	PUNCT
dpc-5458	291	7	zito	zito	PROPN
dpc-5458	291	8	pm	pm	PROPN
dpc-5458	291	9	.	.	PUNCT
dpc-5458	291	10	cyclosporine	cyclosporine	PROPN
dpc-5458	291	11	.	.	PUNCT
dpc-5458	292	1	[	[	X
dpc-5458	292	2	updated	update	VERB
dpc-5458	292	3	2023	2023	NUM
dpc-5458	292	4	aug	aug	NOUN
dpc-5458	292	5	28	28	NUM
dpc-5458	292	6	]	]	PUNCT
dpc-5458	292	7	.	.	PUNCT
dpc-5458	293	1	in	in	ADP
dpc-5458	293	2	:	:	PUNCT
dpc-5458	293	3	statpearls	statpearl	NOUN
dpc-5458	294	1	[	[	X
dpc-5458	294	2	internet	internet	NOUN
dpc-5458	294	3	]	]	PUNCT
dpc-5458	294	4	.	.	PUNCT
dpc-5458	295	1	treasure	treasure	NOUN
dpc-5458	295	2	island	island	NOUN
dpc-5458	295	3	(	(	PUNCT
dpc-5458	295	4	fl	fl	PROPN
dpc-5458	295	5	):	):	PUNCT
dpc-5458	295	6	statpearls	statpearls	PROPN
dpc-5458	295	7	publishing	publishing	NOUN
dpc-5458	295	8	;	;	PUNCT
dpc-5458	295	9	2024	2024	NUM
dpc-5458	295	10	jan-	jan-	NOUN
dpc-5458	295	11	.	.	PUNCT
dpc-5458	296	1	available	available	ADJ
dpc-5458	296	2	from	from	ADP
dpc-5458	296	3	:	:	PUNCT
dpc-5458	296	4	https://www.ncbi.nlm	https://www.ncbi.nlm	X
dpc-5458	296	5	.nih.gov	.nih.gov	SYM
dpc-5458	296	6	/	/	SYM
dpc-5458	296	7	books	book	NOUN
dpc-5458	296	8	/	/	SYM
dpc-5458	296	9	nbk482450/.	nbk482450/.	NOUN
dpc-5458	296	10	23	23	NUM
dpc-5458	296	11	.	.	PUNCT
dpc-5458	297	1	hanoodi	hanoodi	PROPN
dpc-5458	297	2	m	m	PROPN
dpc-5458	297	3	,	,	PUNCT
dpc-5458	297	4	mittal	mittal	PROPN
dpc-5458	297	5	m.	m.	NOUN
dpc-5458	297	6	methotrexate	methotrexate	NOUN
dpc-5458	297	7	.	.	PUNCT
dpc-5458	298	1	[	[	X
dpc-5458	298	2	updated	update	VERB
dpc-5458	298	3	2023	2023	NUM
dpc-5458	298	4	aug	aug	NOUN
dpc-5458	298	5	16	16	NUM
dpc-5458	298	6	]	]	PUNCT
dpc-5458	298	7	.	.	PUNCT
dpc-5458	299	1	in	in	ADP
dpc-5458	299	2	:	:	PUNCT
dpc-5458	299	3	statpearls	statpearl	NOUN
dpc-5458	300	1	[	[	X
dpc-5458	300	2	internet	internet	NOUN
dpc-5458	300	3	]	]	PUNCT
dpc-5458	300	4	.	.	PUNCT
dpc-5458	301	1	treasure	treasure	NOUN
dpc-5458	301	2	island	island	NOUN
dpc-5458	301	3	(	(	PUNCT
dpc-5458	301	4	fl	fl	PROPN
dpc-5458	301	5	):	):	PUNCT
dpc-5458	301	6	statpearls	statpearls	PROPN
dpc-5458	301	7	publishing	publishing	NOUN
dpc-5458	301	8	;	;	PUNCT
dpc-5458	301	9	2024	2024	NUM
dpc-5458	301	10	jan-	jan-	NOUN
dpc-5458	301	11	.	.	PUNCT
dpc-5458	302	1	available	available	ADJ
dpc-5458	302	2	from	from	ADP
dpc-5458	302	3	:	:	PUNCT
dpc-5458	302	4	https://www.ncbi.nlm.nih.gov	https://www.ncbi.nlm.nih.gov	ADJ
dpc-5458	302	5	/books	/book	NOUN
dpc-5458	302	6	/	/	SYM
dpc-5458	302	7	nbk556114/.	nbk556114/.	PROPN
dpc-5458	302	8	24	24	NUM
dpc-5458	302	9	.	.	PUNCT
dpc-5458	303	1	zito	zito	PROPN
dpc-5458	303	2	pm	pm	PROPN
dpc-5458	303	3	,	,	PUNCT
dpc-5458	303	4	patel	patel	NOUN
dpc-5458	303	5	p	p	NOUN
dpc-5458	303	6	,	,	PUNCT
dpc-5458	303	7	mazzoni	mazzoni	PROPN
dpc-5458	303	8	t.	t.	PROPN
dpc-5458	303	9	acitretin	acitretin	PROPN
dpc-5458	303	10	.	.	PUNCT
dpc-5458	304	1	[	[	X
dpc-5458	304	2	updated	update	VERB
dpc-5458	304	3	2024	2024	NUM
dpc-5458	304	4	feb	feb	NOUN
dpc-5458	304	5	28	28	NUM
dpc-5458	304	6	]	]	PUNCT
dpc-5458	304	7	.	.	PUNCT
dpc-5458	305	1	in	in	ADP
dpc-5458	305	2	:	:	PUNCT
dpc-5458	305	3	statpearls	statpearl	NOUN
dpc-5458	306	1	[	[	X
dpc-5458	306	2	internet	internet	NOUN
dpc-5458	306	3	]	]	PUNCT
dpc-5458	306	4	.	.	PUNCT
dpc-5458	307	1	treasure	treasure	NOUN
dpc-5458	307	2	island	island	NOUN
dpc-5458	307	3	(	(	PUNCT
dpc-5458	307	4	fl	fl	PROPN
dpc-5458	307	5	):	):	PUNCT
dpc-5458	307	6	statpearls	statpearl	NOUN
dpc-5458	307	7	publishing	publishing	NOUN
dpc-5458	307	8	;	;	PUNCT
dpc-5458	307	9	10	10	NUM
dpc-5458	307	10	original	original	ADJ
dpc-5458	307	11	article	article	NOUN
dpc-5458	307	12	|	|	ADV
dpc-5458	307	13	dermatol	dermatol	ADJ
dpc-5458	307	14	pract	pract	NOUN
dpc-5458	307	15	concept	concept	NOUN
dpc-5458	307	16	.	.	PUNCT
dpc-5458	308	1	2025;15(4):5458	2025;15(4):5458	NUM
dpc-5458	308	2	28	28	NUM
dpc-5458	308	3	.	.	PUNCT
dpc-5458	309	1	weidmann	weidmann	PROPN
dpc-5458	309	2	a	a	PROPN
dpc-5458	309	3	,	,	PUNCT
dpc-5458	309	4	foulkes	foulkes	PROPN
dpc-5458	309	5	ac	ac	PROPN
dpc-5458	309	6	,	,	PUNCT
dpc-5458	309	7	kirkham	kirkham	PROPN
dpc-5458	309	8	n	n	NUM
dpc-5458	309	9	,	,	PUNCT
dpc-5458	309	10	reynolds	reynolds	PROPN
dpc-5458	309	11	nj	nj	PROPN
dpc-5458	309	12	.	.	PROPN
dpc-5458	309	13	methotrexate	methotrexate	VERB
dpc-5458	309	14	toxicity	toxicity	NOUN
dpc-5458	309	15	during	during	ADP
dpc-5458	309	16	treatment	treatment	NOUN
dpc-5458	309	17	of	of	ADP
dpc-5458	309	18	chronic	chronic	ADJ
dpc-5458	309	19	plaque	plaque	NOUN
dpc-5458	309	20	psoriasis	psoriasis	NOUN
dpc-5458	309	21	:	:	PUNCT
dpc-5458	309	22	a	a	DET
dpc-5458	309	23	case	case	NOUN
dpc-5458	309	24	report	report	NOUN
dpc-5458	309	25	and	and	CCONJ
dpc-5458	309	26	review	review	NOUN
dpc-5458	309	27	of	of	ADP
dpc-5458	309	28	the	the	DET
dpc-5458	309	29	literature	literature	NOUN
dpc-5458	309	30	.	.	PUNCT
dpc-5458	310	1	dermatol	dermatol	NOUN
dpc-5458	310	2	ther	ther	ADV
dpc-5458	310	3	(	(	PUNCT
dpc-5458	310	4	heidelb	heidelb	NOUN
dpc-5458	310	5	)	)	PUNCT
dpc-5458	310	6	.	.	PUNCT
dpc-5458	311	1	2014;4(2):145	2014;4(2):145	NUM
dpc-5458	311	2	-	-	SYM
dpc-5458	311	3	56	56	NUM
dpc-5458	311	4	.	.	PUNCT
dpc-5458	312	1	doi	doi	NOUN
dpc-5458	312	2	:	:	PUNCT
dpc-5458	312	3	10.1007	10.1007	NUM
dpc-5458	312	4	/	/	SYM
dpc-5458	312	5	s13555	s13555	PROPN
dpc-5458	312	6	-	-	PUNCT
dpc-5458	312	7	014	014	NUM
dpc-5458	312	8	-	-	PUNCT
dpc-5458	312	9	0056	0056	NUM
dpc-5458	312	10	-	-	PUNCT
dpc-5458	312	11	z.	z.	PROPN
dpc-5458	312	12	pmid	pmid	PROPN
dpc-5458	312	13	:	:	PUNCT
dpc-5458	312	14	24942326	24942326	NUM
dpc-5458	312	15	.	.	PUNCT
dpc-5458	313	1	29	29	NUM
dpc-5458	313	2	.	.	PUNCT
dpc-5458	313	3	ho	ho	PROPN
dpc-5458	313	4	vc	vc	PROPN
dpc-5458	313	5	,	,	PUNCT
dpc-5458	313	6	griffiths	griffiths	PROPN
dpc-5458	313	7	ce	ce	PROPN
dpc-5458	313	8	,	,	PUNCT
dpc-5458	313	9	albrecht	albrecht	PROPN
dpc-5458	313	10	g	g	PROPN
dpc-5458	313	11	,	,	PUNCT
dpc-5458	313	12	et	et	PROPN
dpc-5458	313	13	al	al	PROPN
dpc-5458	313	14	.	.	PROPN
dpc-5458	314	1	intermittent	intermittent	ADJ
dpc-5458	314	2	short	short	ADJ
dpc-5458	314	3	courses	course	NOUN
dpc-5458	314	4	of	of	ADP
dpc-5458	314	5	cyclosporin	cyclosporin	NOUN
dpc-5458	314	6	(	(	PUNCT
dpc-5458	314	7	neoral(r	neoral(r	NOUN
dpc-5458	314	8	)	)	PUNCT
dpc-5458	314	9	)	)	PUNCT
dpc-5458	314	10	for	for	ADP
dpc-5458	314	11	psoriasis	psoriasis	NOUN
dpc-5458	314	12	unresponsive	unresponsive	ADJ
dpc-5458	314	13	to	to	ADP
dpc-5458	314	14	topical	topical	ADJ
dpc-5458	314	15	therapy	therapy	NOUN
dpc-5458	314	16	:	:	PUNCT
dpc-5458	314	17	a	a	DET
dpc-5458	314	18	1	1	NUM
dpc-5458	314	19	-	-	PUNCT
dpc-5458	314	20	year	year	NOUN
dpc-5458	314	21	multicentre	multicentre	NOUN
dpc-5458	314	22	,	,	PUNCT
dpc-5458	314	23	randomized	randomized	ADJ
dpc-5458	314	24	study	study	NOUN
dpc-5458	314	25	.	.	PUNCT
dpc-5458	315	1	the	the	DET
dpc-5458	315	2	pisces	pisce	NOUN
dpc-5458	315	3	study	study	NOUN
dpc-5458	315	4	group	group	NOUN
dpc-5458	315	5	.	.	PUNCT
dpc-5458	316	1	br	br	PROPN
dpc-5458	316	2	j	j	PROPN
dpc-5458	316	3	dermatol	dermatol	NOUN
dpc-5458	316	4	.	.	PUNCT
dpc-5458	317	1	1999;141(2):283	1999;141(2):283	NUM
dpc-5458	317	2	-	-	SYM
dpc-5458	317	3	91	91	NUM
dpc-5458	317	4	.	.	PUNCT
dpc-5458	318	1	doi	doi	NOUN
dpc-5458	318	2	:	:	PUNCT
dpc-5458	318	3	10.1046	10.1046	NUM
dpc-5458	318	4	/	/	SYM
dpc-5458	318	5	j.1365	j.1365	NOUN
dpc-5458	318	6	-	-	PUNCT
dpc-5458	318	7	2133.1999.02977.x	2133.1999.02977.x	NOUN
dpc-5458	318	8	.	.	PUNCT
dpc-5458	319	1	pmid	pmid	NOUN
dpc-5458	319	2	:	:	PUNCT
dpc-5458	319	3	10468801	10468801	NUM
dpc-5458	319	4	.	.	PUNCT
dpc-5458	320	1	30	30	NUM
dpc-5458	320	2	.	.	PUNCT
dpc-5458	321	1	living	live	VERB
dpc-5458	321	2	euroguiderm	euroguiderm	NOUN
dpc-5458	321	3	guideline	guideline	NOUN
dpc-5458	321	4	for	for	ADP
dpc-5458	321	5	the	the	DET
dpc-5458	321	6	systemic	systemic	ADJ
dpc-5458	321	7	treatment	treatment	NOUN
dpc-5458	321	8	of	of	ADP
dpc-5458	321	9	psoriasis	psoriasis	NOUN
dpc-5458	321	10	vulgaris	vulgaris	NOUN
dpc-5458	321	11	.	.	PUNCT
dpc-5458	322	1	https://www.guidelines.edf.one/guidelines/	https://www.guidelines.edf.one/guidelines/	NOUN
dpc-5458	322	2	psoriasis	psoriasis	NOUN
dpc-5458	322	3	-	-	PUNCT
dpc-5458	322	4	guideline	guideline	NOUN
dpc-5458	322	5	2024	2024	NUM
dpc-5458	322	6	jan-	jan-	NOUN
dpc-5458	322	7	.	.	PUNCT
dpc-5458	323	1	available	available	ADJ
dpc-5458	323	2	from	from	ADP
dpc-5458	323	3	:	:	PUNCT
dpc-5458	323	4	https://www.ncbi.nlm.nih.gov	https://www.ncbi.nlm.nih.gov	ADJ
dpc-5458	323	5	/books	/book	NOUN
dpc-5458	323	6	/	/	SYM
dpc-5458	323	7	nbk519571/.	nbk519571/.	ADV
dpc-5458	323	8	25	25	NUM
dpc-5458	323	9	.	.	PUNCT
dpc-5458	324	1	augustin	augustin	PROPN
dpc-5458	324	2	m	m	PROPN
dpc-5458	324	3	,	,	PUNCT
dpc-5458	324	4	landeck	landeck	ADJ
dpc-5458	324	5	l	l	NOUN
dpc-5458	324	6	,	,	PUNCT
dpc-5458	324	7	diemert	diemert	PROPN
dpc-5458	324	8	s	s	PROPN
dpc-5458	324	9	,	,	PUNCT
dpc-5458	324	10	et	et	PROPN
dpc-5458	324	11	al	al	PROPN
dpc-5458	324	12	.	.	PUNCT
dpc-5458	324	13	treatment	treatment	NOUN
dpc-5458	324	14	with	with	ADP
dpc-5458	324	15	dimethyl	dimethyl	NOUN
dpc-5458	324	16	fumarate	fumarate	NOUN
dpc-5458	324	17	for	for	ADP
dpc-5458	324	18	plaque	plaque	NOUN
dpc-5458	324	19	psoriasis	psoriasis	NOUN
dpc-5458	324	20	in	in	ADP
dpc-5458	324	21	routine	routine	ADJ
dpc-5458	324	22	practice	practice	NOUN
dpc-5458	324	23	:	:	PUNCT
dpc-5458	325	1	good	good	ADJ
dpc-5458	325	2	overall	overall	ADJ
dpc-5458	325	3	effectiveness	effectiveness	NOUN
dpc-5458	325	4	and	and	CCONJ
dpc-5458	325	5	positive	positive	ADJ
dpc-5458	325	6	effect	effect	NOUN
dpc-5458	325	7	on	on	ADP
dpc-5458	325	8	impactful	impactful	ADJ
dpc-5458	325	9	areas	area	NOUN
dpc-5458	325	10	.	.	PUNCT
dpc-5458	326	1	dermatol	dermatol	NOUN
dpc-5458	326	2	ther	ther	ADV
dpc-5458	326	3	(	(	PUNCT
dpc-5458	326	4	heidelb	heidelb	NOUN
dpc-5458	326	5	)	)	PUNCT
dpc-5458	326	6	.	.	PUNCT
dpc-5458	327	1	2022;12(5):1121	2022;12(5):1121	NUM
dpc-5458	327	2	-	-	SYM
dpc-5458	327	3	1131	1131	NUM
dpc-5458	327	4	.	.	PUNCT
dpc-5458	328	1	doi	doi	NOUN
dpc-5458	328	2	:	:	PUNCT
dpc-5458	328	3	10.1007	10.1007	NUM
dpc-5458	328	4	/	/	SYM
dpc-5458	328	5	s13555	s13555	PROPN
dpc-5458	328	6	-	-	PUNCT
dpc-5458	328	7	022	022	NUM
dpc-5458	328	8	-	-	PUNCT
dpc-5458	328	9	00714	00714	NUM
dpc-5458	328	10	-	-	SYM
dpc-5458	328	11	0	0	NUM
dpc-5458	328	12	.	.	PUNCT
dpc-5458	329	1	pmid	pmid	NOUN
dpc-5458	329	2	:	:	PUNCT
dpc-5458	329	3	35403945	35403945	NUM
dpc-5458	329	4	.	.	PUNCT
dpc-5458	330	1	26	26	NUM
dpc-5458	330	2	.	.	PUNCT
dpc-5458	331	1	burlando	burlando	PROPN
dpc-5458	331	2	m	m	PROPN
dpc-5458	331	3	,	,	PUNCT
dpc-5458	331	4	campione	campione	PROPN
dpc-5458	331	5	e	e	NOUN
dpc-5458	331	6	,	,	PUNCT
dpc-5458	331	7	cuccia	cuccia	PROPN
dpc-5458	331	8	a	a	X
dpc-5458	331	9	,	,	PUNCT
dpc-5458	331	10	et	et	PROPN
dpc-5458	331	11	al	al	PROPN
dpc-5458	331	12	.	.	PUNCT
dpc-5458	332	1	real	real	ADJ
dpc-5458	332	2	-	-	PUNCT
dpc-5458	332	3	world	world	NOUN
dpc-5458	332	4	use	use	NOUN
dpc-5458	332	5	of	of	ADP
dpc-5458	332	6	dimethyl	dimethyl	NOUN
dpc-5458	332	7	fumarate	fumarate	NOUN
dpc-5458	332	8	in	in	ADP
dpc-5458	332	9	patients	patient	NOUN
dpc-5458	332	10	with	with	ADP
dpc-5458	332	11	plaque	plaque	NOUN
dpc-5458	332	12	psoriasis	psoriasis	NOUN
dpc-5458	332	13	:	:	PUNCT
dpc-5458	332	14	a	a	DET
dpc-5458	332	15	delphi	delphi	NOUN
dpc-5458	332	16	-	-	PUNCT
dpc-5458	332	17	based	base	VERB
dpc-5458	332	18	expert	expert	ADJ
dpc-5458	332	19	consensus	consensus	NOUN
dpc-5458	332	20	.	.	PUNCT
dpc-5458	333	1	dermatol	dermatol	NOUN
dpc-5458	333	2	reports	report	NOUN
dpc-5458	333	3	.	.	PUNCT
dpc-5458	334	1	2022;15(2):9613	2022;15(2):9613	NUM
dpc-5458	334	2	.	.	PUNCT
dpc-5458	335	1	doi	doi	NOUN
dpc-5458	335	2	:	:	PUNCT
dpc-5458	335	3	10.4081	10.4081	NUM
dpc-5458	335	4	/	/	SYM
dpc-5458	335	5	dr.2023.9613	dr.2023.9613	NOUN
dpc-5458	335	6	.	.	PUNCT
dpc-5458	336	1	pmid	pmid	NOUN
dpc-5458	336	2	:	:	PUNCT
dpc-5458	336	3	37426359	37426359	NUM
dpc-5458	336	4	.	.	PUNCT
dpc-5458	337	1	27	27	NUM
dpc-5458	337	2	.	.	PUNCT
dpc-5458	338	1	campbell	campbell	PROPN
dpc-5458	338	2	f	f	PROPN
dpc-5458	338	3	,	,	PUNCT
dpc-5458	338	4	laws	law	NOUN
dpc-5458	338	5	p.	p.	NOUN
dpc-5458	338	6	managing	manage	VERB
dpc-5458	338	7	risk	risk	NOUN
dpc-5458	338	8	of	of	ADP
dpc-5458	338	9	liver	liver	NOUN
dpc-5458	338	10	fibrosis	fibrosis	NOUN
dpc-5458	338	11	in	in	ADP
dpc-5458	338	12	patients	patient	NOUN
dpc-5458	338	13	with	with	ADP
dpc-5458	338	14	psoriasis	psoriasis	NOUN
dpc-5458	338	15	being	be	AUX
dpc-5458	338	16	considered	consider	VERB
dpc-5458	338	17	for	for	ADP
dpc-5458	338	18	methotrexate	methotrexate	NOUN
dpc-5458	338	19	.	.	PUNCT
dpc-5458	339	1	br	br	PROPN
dpc-5458	339	2	j	j	PROPN
dpc-5458	339	3	dermatol	dermatol	NOUN
dpc-5458	339	4	.	.	PUNCT
dpc-5458	340	1	2024;191(2):163	2024;191(2):163	NUM
dpc-5458	340	2	.	.	PUNCT
dpc-5458	341	1	doi	doi	NOUN
dpc-5458	341	2	:	:	PUNCT
dpc-5458	341	3	10.1093	10.1093	NUM
dpc-5458	341	4	/	/	SYM
dpc-5458	341	5	bjd	bjd	PROPN
dpc-5458	341	6	/	/	SYM
dpc-5458	341	7	ljae114	ljae114	PROPN
dpc-5458	341	8	.	.	PUNCT
dpc-5458	342	1	pmid	pmid	PROPN
dpc-5458	342	2	:	:	PUNCT
dpc-5458	342	3	38504462	38504462	NUM
dpc-5458	342	4	.	.	PUNCT