id	sid	tid	token	lemma	pos
dpc-5612	1	1	dermatology	dermatology	NOUN
dpc-5612	1	2	:	:	PUNCT
dpc-5612	1	3	practical	practical	ADJ
dpc-5612	1	4	and	and	CCONJ
dpc-5612	1	5	conceptual	conceptual	ADJ
dpc-5612	1	6	original	original	ADJ
dpc-5612	1	7	article	article	NOUN
dpc-5612	1	8	|	|	ADV
dpc-5612	1	9	dermatol	dermatol	ADJ
dpc-5612	1	10	pract	pract	NOUN
dpc-5612	1	11	concept	concept	NOUN
dpc-5612	1	12	.	.	PUNCT
dpc-5612	2	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	2	2	1	1	NUM
dpc-5612	2	3	real	real	ADJ
dpc-5612	2	4	-	-	PUNCT
dpc-5612	2	5	world	world	NOUN
dpc-5612	2	6	safety	safety	NOUN
dpc-5612	2	7	of	of	ADP
dpc-5612	2	8	oral	oral	ADJ
dpc-5612	2	9	isotretinoin	isotretinoin	NOUN
dpc-5612	2	10	in	in	ADP
dpc-5612	2	11	patients	patient	NOUN
dpc-5612	2	12	during	during	ADP
dpc-5612	2	13	sunny	sunny	ADJ
dpc-5612	2	14	months	month	NOUN
dpc-5612	2	15	:	:	PUNCT
dpc-5612	2	16	retrospective	retrospective	ADJ
dpc-5612	2	17	cohort	cohort	NOUN
dpc-5612	2	18	study	study	NOUN
dpc-5612	2	19	elisa	elisa	PROPN
dpc-5612	2	20	marzola1	marzola1	PROPN
dpc-5612	2	21	,	,	PUNCT
dpc-5612	2	22	emma	emma	PROPN
dpc-5612	2	23	pedarzani2	pedarzani2	PROPN
dpc-5612	2	24	,	,	PUNCT
dpc-5612	2	25	giorgia	giorgia	PROPN
dpc-5612	2	26	valpiani2	valpiani2	PROPN
dpc-5612	2	27	,	,	PUNCT
dpc-5612	2	28	sofia	sofia	PROPN
dpc-5612	2	29	fraternale1,2	fraternale1,2	PROPN
dpc-5612	2	30	,	,	PUNCT
dpc-5612	2	31	giulia	giulia	PROPN
dpc-5612	2	32	toni1	toni1	PROPN
dpc-5612	2	33	,	,	PUNCT
dpc-5612	2	34	vincenzo	vincenzo	PROPN
dpc-5612	2	35	bettoli1	bettoli1	PROPN
dpc-5612	2	36	,	,	PUNCT
dpc-5612	2	37	monica	monica	PROPN
dpc-5612	2	38	corazza1	corazza1	PROPN
dpc-5612	2	39	,	,	PUNCT
dpc-5612	2	40	alessandro	alessandro	PROPN
dpc-5612	2	41	borghi1	borghi1	NOUN
dpc-5612	2	42	1	1	NUM
dpc-5612	2	43	section	section	NOUN
dpc-5612	2	44	of	of	ADP
dpc-5612	2	45	dermatology	dermatology	NOUN
dpc-5612	2	46	and	and	CCONJ
dpc-5612	2	47	infectious	infectious	ADJ
dpc-5612	2	48	diseases	disease	NOUN
dpc-5612	2	49	,	,	PUNCT
dpc-5612	2	50	department	department	NOUN
dpc-5612	2	51	of	of	ADP
dpc-5612	2	52	medical	medical	ADJ
dpc-5612	2	53	sciences	sciences	PROPN
dpc-5612	2	54	,	,	PUNCT
dpc-5612	2	55	university	university	NOUN
dpc-5612	2	56	of	of	ADP
dpc-5612	2	57	ferrara	ferrara	NOUN
dpc-5612	2	58	,	,	PUNCT
dpc-5612	2	59	ferrara	ferrara	NOUN
dpc-5612	2	60	,	,	PUNCT
dpc-5612	2	61	italy	italy	PROPN
dpc-5612	2	62	2	2	NUM
dpc-5612	2	63	research	research	NOUN
dpc-5612	2	64	and	and	CCONJ
dpc-5612	2	65	innovation	innovation	NOUN
dpc-5612	2	66	unit	unit	NOUN
dpc-5612	2	67	,	,	PUNCT
dpc-5612	2	68	biostatistics	biostatistic	NOUN
dpc-5612	2	69	and	and	CCONJ
dpc-5612	2	70	clinical	clinical	ADJ
dpc-5612	2	71	trial	trial	NOUN
dpc-5612	2	72	area	area	NOUN
dpc-5612	2	73	,	,	PUNCT
dpc-5612	2	74	university	university	NOUN
dpc-5612	2	75	hospital	hospital	NOUN
dpc-5612	2	76	of	of	ADP
dpc-5612	2	77	ferrara	ferrara	NOUN
dpc-5612	2	78	,	,	PUNCT
dpc-5612	2	79	ferrara	ferrara	NOUN
dpc-5612	2	80	,	,	PUNCT
dpc-5612	2	81	italy	italy	PROPN
dpc-5612	2	82	key	key	ADJ
dpc-5612	2	83	words	word	NOUN
dpc-5612	2	84	:	:	PUNCT
dpc-5612	2	85	oral	oral	ADJ
dpc-5612	2	86	isotretinoin	isotretinoin	PROPN
dpc-5612	2	87	,	,	PUNCT
dpc-5612	2	88	acne	acne	NOUN
dpc-5612	2	89	,	,	PUNCT
dpc-5612	2	90	seasonality	seasonality	NOUN
dpc-5612	2	91	,	,	PUNCT
dpc-5612	2	92	safety	safety	NOUN
dpc-5612	2	93	,	,	PUNCT
dpc-5612	2	94	sun	sun	NOUN
dpc-5612	2	95	exposure	exposure	NOUN
dpc-5612	2	96	citation	citation	NOUN
dpc-5612	2	97	:	:	PUNCT
dpc-5612	2	98	marzola	marzola	PROPN
dpc-5612	2	99	e	e	NOUN
dpc-5612	2	100	,	,	PUNCT
dpc-5612	2	101	pedarzani	pedarzani	NOUN
dpc-5612	2	102	e	e	NOUN
dpc-5612	2	103	,	,	PUNCT
dpc-5612	2	104	valpiani	valpiani	PROPN
dpc-5612	2	105	g	g	PROPN
dpc-5612	2	106	,	,	PUNCT
dpc-5612	2	107	fraternale	fraternale	PROPN
dpc-5612	2	108	s	s	PROPN
dpc-5612	2	109	,	,	PUNCT
dpc-5612	2	110	toni	toni	NOUN
dpc-5612	2	111	g	g	NOUN
dpc-5612	2	112	,	,	PUNCT
dpc-5612	2	113	bettoli	bettoli	ADP
dpc-5612	2	114	v	v	NOUN
dpc-5612	2	115	,	,	PUNCT
dpc-5612	2	116	et	et	PROPN
dpc-5612	2	117	al	al	PROPN
dpc-5612	2	118	.	.	PUNCT
dpc-5612	3	1	real	real	ADJ
dpc-5612	3	2	-	-	PUNCT
dpc-5612	3	3	world	world	NOUN
dpc-5612	3	4	safety	safety	NOUN
dpc-5612	3	5	of	of	ADP
dpc-5612	3	6	oral	oral	ADJ
dpc-5612	3	7	isotretinoin	isotretinoin	NOUN
dpc-5612	3	8	in	in	ADP
dpc-5612	3	9	patients	patient	NOUN
dpc-5612	3	10	during	during	ADP
dpc-5612	3	11	sunny	sunny	ADJ
dpc-5612	3	12	months	month	NOUN
dpc-5612	3	13	:	:	PUNCT
dpc-5612	3	14	retrospective	retrospective	ADJ
dpc-5612	3	15	cohort	cohort	NOUN
dpc-5612	3	16	study	study	NOUN
dpc-5612	3	17	.	.	PUNCT
dpc-5612	4	1	dermatol	dermatol	NOUN
dpc-5612	4	2	pract	pract	PROPN
dpc-5612	4	3	concept	concept	NOUN
dpc-5612	4	4	.	.	PUNCT
dpc-5612	5	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	5	2	.	.	PUNCT
dpc-5612	6	1	doi	doi	NOUN
dpc-5612	6	2	:	:	PUNCT
dpc-5612	6	3	https://doi.org/10.5826	https://doi.org/10.5826	PROPN
dpc-5612	6	4	/dpc.1504a5612	/dpc.1504a5612	PROPN
dpc-5612	6	5	accepted	accept	VERB
dpc-5612	6	6	:	:	PUNCT
dpc-5612	6	7	june	june	PROPN
dpc-5612	6	8	28	28	NUM
dpc-5612	6	9	,	,	PUNCT
dpc-5612	6	10	2025	2025	NUM
dpc-5612	6	11	;	;	PUNCT
dpc-5612	6	12	published	publish	VERB
dpc-5612	6	13	:	:	PUNCT
dpc-5612	7	1	october	october	PROPN
dpc-5612	7	2	2025	2025	NUM
dpc-5612	7	3	copyright	copyright	NOUN
dpc-5612	7	4	:	:	PUNCT
dpc-5612	7	5	©	©	PROPN
dpc-5612	7	6	2025	2025	NUM
dpc-5612	7	7	marzola	marzola	NOUN
dpc-5612	7	8	et	et	PROPN
dpc-5612	7	9	al	al	PROPN
dpc-5612	7	10	.	.	PUNCT
dpc-5612	8	1	this	this	PRON
dpc-5612	8	2	is	be	AUX
dpc-5612	8	3	an	an	DET
dpc-5612	8	4	open	open	ADJ
dpc-5612	8	5	-	-	PUNCT
dpc-5612	8	6	access	access	NOUN
dpc-5612	8	7	article	article	NOUN
dpc-5612	8	8	distributed	distribute	VERB
dpc-5612	8	9	under	under	ADP
dpc-5612	8	10	the	the	DET
dpc-5612	8	11	terms	term	NOUN
dpc-5612	8	12	of	of	ADP
dpc-5612	8	13	the	the	DET
dpc-5612	8	14	creative	creative	ADJ
dpc-5612	8	15	commons	common	NOUN
dpc-5612	8	16	attributionnoncommercial	attributionnoncommercial	ADJ
dpc-5612	8	17	license	license	NOUN
dpc-5612	8	18	(	(	PUNCT
dpc-5612	8	19	by	by	ADP
dpc-5612	8	20	-	-	PUNCT
dpc-5612	8	21	nc-4.0	nc-4.0	NOUN
dpc-5612	8	22	)	)	PUNCT
dpc-5612	8	23	,	,	PUNCT
dpc-5612	8	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-5612	8	25	,	,	PUNCT
dpc-5612	8	26	which	which	PRON
dpc-5612	8	27	permits	permit	VERB
dpc-5612	8	28	unrestricted	unrestricted	ADJ
dpc-5612	8	29	noncommercial	noncommercial	ADJ
dpc-5612	8	30	use	use	NOUN
dpc-5612	8	31	,	,	PUNCT
dpc-5612	8	32	distribution	distribution	NOUN
dpc-5612	8	33	,	,	PUNCT
dpc-5612	8	34	and	and	CCONJ
dpc-5612	8	35	reproduction	reproduction	NOUN
dpc-5612	8	36	in	in	ADP
dpc-5612	8	37	any	any	DET
dpc-5612	8	38	medium	medium	NOUN
dpc-5612	8	39	,	,	PUNCT
dpc-5612	8	40	provided	provide	VERB
dpc-5612	8	41	the	the	DET
dpc-5612	8	42	original	original	ADJ
dpc-5612	8	43	authors	author	NOUN
dpc-5612	8	44	and	and	CCONJ
dpc-5612	8	45	source	source	NOUN
dpc-5612	8	46	are	be	AUX
dpc-5612	8	47	credited	credit	VERB
dpc-5612	8	48	.	.	PUNCT
dpc-5612	9	1	funding	funding	NOUN
dpc-5612	9	2	:	:	PUNCT
dpc-5612	9	3	none	none	NOUN
dpc-5612	9	4	.	.	PUNCT
dpc-5612	10	1	competing	compete	VERB
dpc-5612	10	2	interests	interest	NOUN
dpc-5612	10	3	:	:	PUNCT
dpc-5612	10	4	none	none	NOUN
dpc-5612	10	5	.	.	PUNCT
dpc-5612	11	1	authorship	authorship	NOUN
dpc-5612	11	2	:	:	PUNCT
dpc-5612	11	3	all	all	DET
dpc-5612	11	4	authors	author	NOUN
dpc-5612	11	5	have	have	AUX
dpc-5612	11	6	contributed	contribute	VERB
dpc-5612	11	7	significantly	significantly	ADV
dpc-5612	11	8	to	to	ADP
dpc-5612	11	9	this	this	DET
dpc-5612	11	10	publication	publication	NOUN
dpc-5612	11	11	.	.	PUNCT
dpc-5612	12	1	corresponding	correspond	VERB
dpc-5612	12	2	author	author	NOUN
dpc-5612	12	3	:	:	PUNCT
dpc-5612	12	4	elisa	elisa	PROPN
dpc-5612	12	5	marzola	marzola	PROPN
dpc-5612	12	6	,	,	PUNCT
dpc-5612	12	7	md	md	PROPN
dpc-5612	12	8	,	,	PUNCT
dpc-5612	12	9	section	section	NOUN
dpc-5612	12	10	of	of	ADP
dpc-5612	12	11	dermatology	dermatology	NOUN
dpc-5612	12	12	and	and	CCONJ
dpc-5612	12	13	infectious	infectious	ADJ
dpc-5612	12	14	diseases	disease	NOUN
dpc-5612	12	15	,	,	PUNCT
dpc-5612	12	16	department	department	NOUN
dpc-5612	12	17	of	of	ADP
dpc-5612	12	18	medical	medical	ADJ
dpc-5612	12	19	sciences	sciences	PROPN
dpc-5612	12	20	,	,	PUNCT
dpc-5612	12	21	university	university	NOUN
dpc-5612	12	22	of	of	ADP
dpc-5612	12	23	ferrara	ferrara	NOUN
dpc-5612	12	24	,	,	PUNCT
dpc-5612	12	25	via	via	ADP
dpc-5612	12	26	l.	l.	PROPN
dpc-5612	12	27	ariosto	ariosto	PROPN
dpc-5612	12	28	35	35	NUM
dpc-5612	12	29	,	,	PUNCT
dpc-5612	12	30	44121	44121	NUM
dpc-5612	12	31	,	,	PUNCT
dpc-5612	12	32	ferrara	ferrara	NOUN
dpc-5612	12	33	,	,	PUNCT
dpc-5612	12	34	italy	italy	PROPN
dpc-5612	12	35	.	.	PUNCT
dpc-5612	13	1	orcid	orcid	PROPN
dpc-5612	14	1	i	i	PRON
dpc-5612	14	2	d	d	NOUN
dpc-5612	14	3	:	:	PUNCT
dpc-5612	14	4	0000	0000	NUM
dpc-5612	14	5	-	-	PUNCT
dpc-5612	14	6	0002	0002	NUM
dpc-5612	14	7	-	-	PUNCT
dpc-5612	14	8	5905	5905	NUM
dpc-5612	14	9	-	-	PUNCT
dpc-5612	14	10	6186	6186	NUM
dpc-5612	14	11	.	.	PUNCT
dpc-5612	15	1	email	email	NOUN
dpc-5612	15	2	:	:	PUNCT
dpc-5612	15	3	elis.marzola@gmail.com	elis.marzola@gmail.com	X
dpc-5612	15	4	.	.	PUNCT
dpc-5612	16	1	introduction	introduction	NOUN
dpc-5612	16	2	:	:	PUNCT
dpc-5612	16	3	there	there	PRON
dpc-5612	16	4	is	be	VERB
dpc-5612	16	5	a	a	DET
dpc-5612	16	6	widespread	widespread	ADJ
dpc-5612	16	7	clinical	clinical	ADJ
dpc-5612	16	8	practice	practice	NOUN
dpc-5612	16	9	of	of	ADP
dpc-5612	16	10	avoiding	avoid	VERB
dpc-5612	16	11	oral	oral	ADJ
dpc-5612	16	12	isotretinoin	isotretinoin	PROPN
dpc-5612	16	13	administration	administration	NOUN
dpc-5612	16	14	during	during	ADP
dpc-5612	16	15	the	the	DET
dpc-5612	16	16	sunny	sunny	ADJ
dpc-5612	16	17	season	season	NOUN
dpc-5612	16	18	due	due	ADP
dpc-5612	16	19	to	to	ADP
dpc-5612	16	20	its	its	PRON
dpc-5612	16	21	purported	purport	VERB
dpc-5612	16	22	photosensitizing	photosensitize	VERB
dpc-5612	16	23	effect	effect	NOUN
dpc-5612	16	24	.	.	PUNCT
dpc-5612	17	1	however	however	ADV
dpc-5612	17	2	,	,	PUNCT
dpc-5612	17	3	this	this	DET
dpc-5612	17	4	approach	approach	NOUN
dpc-5612	17	5	is	be	AUX
dpc-5612	17	6	not	not	PART
dpc-5612	17	7	supported	support	VERB
dpc-5612	17	8	by	by	ADP
dpc-5612	17	9	solid	solid	ADJ
dpc-5612	17	10	evidence	evidence	NOUN
dpc-5612	17	11	.	.	PUNCT
dpc-5612	18	1	objective	objective	NOUN
dpc-5612	18	2	:	:	PUNCT
dpc-5612	18	3	the	the	DET
dpc-5612	18	4	aim	aim	NOUN
dpc-5612	18	5	of	of	ADP
dpc-5612	18	6	this	this	DET
dpc-5612	18	7	study	study	NOUN
dpc-5612	18	8	was	be	AUX
dpc-5612	18	9	to	to	PART
dpc-5612	18	10	assess	assess	VERB
dpc-5612	18	11	the	the	DET
dpc-5612	18	12	safety	safety	NOUN
dpc-5612	18	13	and	and	CCONJ
dpc-5612	18	14	effectiveness	effectiveness	NOUN
dpc-5612	18	15	of	of	ADP
dpc-5612	18	16	administering	administer	VERB
dpc-5612	18	17	oral	oral	ADJ
dpc-5612	18	18	isotretinoin	isotretinoin	NOUN
dpc-5612	18	19	at	at	ADP
dpc-5612	18	20	a	a	DET
dpc-5612	18	21	reduced	reduce	VERB
dpc-5612	18	22	daily	daily	ADJ
dpc-5612	18	23	dosage	dosage	NOUN
dpc-5612	18	24	during	during	ADP
dpc-5612	18	25	the	the	DET
dpc-5612	18	26	sunny	sunny	ADJ
dpc-5612	18	27	period	period	NOUN
dpc-5612	18	28	in	in	ADP
dpc-5612	18	29	a	a	DET
dpc-5612	18	30	real	real	ADJ
dpc-5612	18	31	-	-	PUNCT
dpc-5612	18	32	world	world	NOUN
dpc-5612	18	33	clinical	clinical	ADJ
dpc-5612	18	34	setting	setting	NOUN
dpc-5612	18	35	.	.	PUNCT
dpc-5612	19	1	methods	method	NOUN
dpc-5612	19	2	:	:	PUNCT
dpc-5612	19	3	this	this	DET
dpc-5612	19	4	retrospective	retrospective	ADJ
dpc-5612	19	5	cohort	cohort	NOUN
dpc-5612	19	6	study	study	NOUN
dpc-5612	19	7	included	include	VERB
dpc-5612	19	8	all	all	DET
dpc-5612	19	9	acne	acne	NOUN
dpc-5612	19	10	patients	patient	NOUN
dpc-5612	19	11	treated	treat	VERB
dpc-5612	19	12	with	with	ADP
dpc-5612	19	13	oral	oral	ADJ
dpc-5612	19	14	isotretinoin	isotretinoin	NOUN
dpc-5612	19	15	at	at	ADP
dpc-5612	19	16	our	our	PRON
dpc-5612	19	17	acne	acne	NOUN
dpc-5612	19	18	clinic	clinic	NOUN
dpc-5612	19	19	(	(	PUNCT
dpc-5612	19	20	january	january	PROPN
dpc-5612	19	21	2014	2014	NUM
dpc-5612	19	22	december	december	PROPN
dpc-5612	19	23	2023	2023	NUM
dpc-5612	19	24	)	)	PUNCT
dpc-5612	19	25	who	who	PRON
dpc-5612	19	26	had	have	AUX
dpc-5612	19	27	received	receive	VERB
dpc-5612	19	28	the	the	DET
dpc-5612	19	29	drug	drug	NOUN
dpc-5612	19	30	between	between	ADP
dpc-5612	19	31	june	june	PROPN
dpc-5612	19	32	and	and	CCONJ
dpc-5612	19	33	september	september	PROPN
dpc-5612	19	34	,	,	PUNCT
dpc-5612	19	35	when	when	SCONJ
dpc-5612	19	36	uv	uv	NOUN
dpc-5612	19	37	index	index	NOUN
dpc-5612	19	38	exceeds	exceed	VERB
dpc-5612	19	39	a	a	DET
dpc-5612	19	40	threshold	threshold	NOUN
dpc-5612	19	41	of	of	ADP
dpc-5612	19	42	6	6	NUM
dpc-5612	19	43	.	.	PUNCT
dpc-5612	20	1	conventionally	conventionally	ADV
dpc-5612	20	2	,	,	PUNCT
dpc-5612	20	3	oral	oral	ADJ
dpc-5612	20	4	isotretinoin	isotretinoin	PROPN
dpc-5612	20	5	daily	daily	ADJ
dpc-5612	20	6	dosage	dosage	NOUN
dpc-5612	20	7	is	be	AUX
dpc-5612	20	8	reduced	reduce	VERB
dpc-5612	20	9	by	by	ADP
dpc-5612	20	10	approximately	approximately	ADV
dpc-5612	20	11	half	half	NOUN
dpc-5612	20	12	during	during	ADP
dpc-5612	20	13	these	these	DET
dpc-5612	20	14	four	four	NUM
dpc-5612	20	15	sunny	sunny	ADJ
dpc-5612	20	16	months	month	NOUN
dpc-5612	20	17	and	and	CCONJ
dpc-5612	20	18	then	then	ADV
dpc-5612	20	19	increased	increase	VERB
dpc-5612	20	20	again	again	ADV
dpc-5612	20	21	.	.	PUNCT
dpc-5612	21	1	we	we	PRON
dpc-5612	21	2	compared	compare	VERB
dpc-5612	21	3	the	the	DET
dpc-5612	21	4	occurrence	occurrence	NOUN
dpc-5612	21	5	of	of	ADP
dpc-5612	21	6	side	side	NOUN
dpc-5612	21	7	effects	effect	NOUN
dpc-5612	21	8	or	or	CCONJ
dpc-5612	21	9	treatment	treatment	NOUN
dpc-5612	21	10	discontinuation	discontinuation	NOUN
dpc-5612	21	11	between	between	ADP
dpc-5612	21	12	sunny	sunny	ADJ
dpc-5612	21	13	and	and	CCONJ
dpc-5612	21	14	non	non	ADJ
dpc-5612	21	15	-	-	ADJ
dpc-5612	21	16	sunny	sunny	ADJ
dpc-5612	21	17	periods	period	NOUN
dpc-5612	21	18	.	.	PUNCT
dpc-5612	22	1	the	the	DET
dpc-5612	22	2	therapeutic	therapeutic	ADJ
dpc-5612	22	3	response	response	NOUN
dpc-5612	22	4	was	be	AUX
dpc-5612	22	5	explored	explore	VERB
dpc-5612	22	6	in	in	ADP
dpc-5612	22	7	relation	relation	NOUN
dpc-5612	22	8	to	to	ADP
dpc-5612	22	9	the	the	DET
dpc-5612	22	10	daily	daily	ADJ
dpc-5612	22	11	dosage	dosage	NOUN
dpc-5612	22	12	.	.	PUNCT
dpc-5612	23	1	results	result	NOUN
dpc-5612	23	2	:	:	PUNCT
dpc-5612	23	3	359	359	NUM
dpc-5612	23	4	patients	patient	NOUN
dpc-5612	23	5	(	(	PUNCT
dpc-5612	23	6	61.3	61.3	NUM
dpc-5612	23	7	%	%	NOUN
dpc-5612	23	8	males	male	NOUN
dpc-5612	23	9	,	,	PUNCT
dpc-5612	23	10	with	with	ADP
dpc-5612	23	11	a	a	DET
dpc-5612	23	12	mean	mean	ADJ
dpc-5612	23	13	age	age	NOUN
dpc-5612	23	14	of	of	ADP
dpc-5612	23	15	19.0	19.0	NUM
dpc-5612	23	16	years	year	NOUN
dpc-5612	23	17	,	,	PUNCT
dpc-5612	23	18	standard	standard	ADJ
dpc-5612	23	19	deviation	deviation	NOUN
dpc-5612	23	20	(	(	PUNCT
dpc-5612	23	21	sd	sd	NOUN
dpc-5612	23	22	)	)	PUNCT
dpc-5612	23	23	6.7	6.7	NUM
dpc-5612	23	24	)	)	PUNCT
dpc-5612	23	25	were	be	AUX
dpc-5612	23	26	included	include	VERB
dpc-5612	23	27	.	.	PUNCT
dpc-5612	24	1	adverse	adverse	ADJ
dpc-5612	24	2	events	event	NOUN
dpc-5612	24	3	were	be	AUX
dpc-5612	24	4	reported	report	VERB
dpc-5612	24	5	by	by	ADP
dpc-5612	24	6	39.2	39.2	NUM
dpc-5612	24	7	%	%	NOUN
dpc-5612	24	8	and	and	CCONJ
dpc-5612	24	9	28.3	28.3	NUM
dpc-5612	24	10	%	%	NOUN
dpc-5612	24	11	of	of	ADP
dpc-5612	24	12	patients	patient	NOUN
dpc-5612	24	13	during	during	ADP
dpc-5612	24	14	the	the	DET
dpc-5612	24	15	non	non	ADJ
dpc-5612	24	16	-	-	ADJ
dpc-5612	24	17	sunny	sunny	ADJ
dpc-5612	24	18	and	and	CCONJ
dpc-5612	24	19	sunny	sunny	ADJ
dpc-5612	24	20	months	month	NOUN
dpc-5612	24	21	,	,	PUNCT
dpc-5612	24	22	respectively	respectively	ADV
dpc-5612	24	23	.	.	PUNCT
dpc-5612	25	1	the	the	DET
dpc-5612	25	2	incidence	incidence	NOUN
dpc-5612	25	3	of	of	ADP
dpc-5612	25	4	treatment	treatment	NOUN
dpc-5612	25	5	discontinuation	discontinuation	NOUN
dpc-5612	25	6	was	be	AUX
dpc-5612	25	7	negligible	negligible	ADJ
dpc-5612	25	8	.	.	PUNCT
dpc-5612	26	1	the	the	DET
dpc-5612	26	2	reduction	reduction	NOUN
dpc-5612	26	3	in	in	ADP
dpc-5612	26	4	acne	acne	NOUN
dpc-5612	26	5	severity	severity	NOUN
dpc-5612	26	6	was	be	AUX
dpc-5612	26	7	independent	independent	ADJ
dpc-5612	26	8	of	of	ADP
dpc-5612	26	9	the	the	DET
dpc-5612	26	10	daily	daily	ADJ
dpc-5612	26	11	dosage	dosage	NOUN
dpc-5612	26	12	of	of	ADP
dpc-5612	26	13	oral	oral	ADJ
dpc-5612	26	14	isotretinoin	isotretinoin	PROPN
dpc-5612	26	15	.	.	PUNCT
dpc-5612	27	1	conclusions	conclusion	NOUN
dpc-5612	27	2	:	:	PUNCT
dpc-5612	27	3	the	the	DET
dpc-5612	27	4	study	study	NOUN
dpc-5612	27	5	results	result	VERB
dpc-5612	27	6	support	support	VERB
dpc-5612	27	7	the	the	DET
dpc-5612	27	8	lack	lack	NOUN
dpc-5612	27	9	of	of	ADP
dpc-5612	27	10	any	any	DET
dpc-5612	27	11	necessity	necessity	NOUN
dpc-5612	27	12	to	to	PART
dpc-5612	27	13	suspend	suspend	VERB
dpc-5612	27	14	or	or	CCONJ
dpc-5612	27	15	refrain	refrain	VERB
dpc-5612	27	16	from	from	ADP
dpc-5612	27	17	administering	administer	VERB
dpc-5612	27	18	oral	oral	ADJ
dpc-5612	27	19	isotretinoin	isotretinoin	NOUN
dpc-5612	27	20	during	during	ADP
dpc-5612	27	21	sunny	sunny	ADJ
dpc-5612	27	22	seasons	season	NOUN
dpc-5612	27	23	.	.	PUNCT
dpc-5612	28	1	the	the	DET
dpc-5612	28	2	preventive	preventive	ADJ
dpc-5612	28	3	reduction	reduction	NOUN
dpc-5612	28	4	of	of	ADP
dpc-5612	28	5	its	its	PRON
dpc-5612	28	6	daily	daily	ADJ
dpc-5612	28	7	dosage	dosage	NOUN
dpc-5612	28	8	during	during	ADP
dpc-5612	28	9	sunny	sunny	ADJ
dpc-5612	28	10	periods	period	NOUN
dpc-5612	28	11	does	do	AUX
dpc-5612	28	12	not	not	PART
dpc-5612	28	13	negatively	negatively	ADV
dpc-5612	28	14	affect	affect	VERB
dpc-5612	28	15	the	the	DET
dpc-5612	28	16	drug	drug	NOUN
dpc-5612	28	17	's	's	PART
dpc-5612	28	18	effectiveness	effectiveness	NOUN
dpc-5612	28	19	.	.	PUNCT
dpc-5612	29	1	oral	oral	ADJ
dpc-5612	29	2	isotretinoin	isotretinoin	PROPN
dpc-5612	29	3	can	can	AUX
dpc-5612	29	4	be	be	AUX
dpc-5612	29	5	taken	take	VERB
dpc-5612	29	6	,	,	PUNCT
dpc-5612	29	7	at	at	ADP
dpc-5612	29	8	a	a	DET
dpc-5612	29	9	slightly	slightly	ADV
dpc-5612	29	10	reduced	reduce	VERB
dpc-5612	29	11	dosage	dosage	NOUN
dpc-5612	29	12	,	,	PUNCT
dpc-5612	29	13	during	during	ADP
dpc-5612	29	14	sunny	sunny	ADJ
dpc-5612	29	15	months	month	NOUN
dpc-5612	29	16	.	.	PUNCT
dpc-5612	30	1	abstract	abstract	ADJ
dpc-5612	30	2	2	2	NUM
dpc-5612	30	3	original	original	ADJ
dpc-5612	30	4	article	article	NOUN
dpc-5612	30	5	|	|	ADV
dpc-5612	30	6	dermatol	dermatol	ADJ
dpc-5612	30	7	pract	pract	NOUN
dpc-5612	30	8	concept	concept	NOUN
dpc-5612	30	9	.	.	PUNCT
dpc-5612	31	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	31	2	introduction	introduction	NOUN
dpc-5612	31	3	oral	oral	ADJ
dpc-5612	31	4	isotretinoin	isotretinoin	PROPN
dpc-5612	31	5	is	be	AUX
dpc-5612	31	6	the	the	DET
dpc-5612	31	7	most	most	ADV
dpc-5612	31	8	effective	effective	ADJ
dpc-5612	31	9	therapeutic	therapeutic	ADJ
dpc-5612	31	10	option	option	NOUN
dpc-5612	31	11	for	for	ADP
dpc-5612	31	12	acne	acne	NOUN
dpc-5612	31	13	by	by	ADP
dpc-5612	31	14	virtue	virtue	NOUN
dpc-5612	31	15	of	of	ADP
dpc-5612	31	16	its	its	PRON
dpc-5612	31	17	broad	broad	ADJ
dpc-5612	31	18	spectrum	spectrum	NOUN
dpc-5612	31	19	of	of	ADP
dpc-5612	31	20	action	action	NOUN
dpc-5612	31	21	[	[	X
dpc-5612	31	22	1,2	1,2	NUM
dpc-5612	31	23	]	]	PUNCT
dpc-5612	31	24	.	.	PUNCT
dpc-5612	32	1	according	accord	VERB
dpc-5612	32	2	to	to	ADP
dpc-5612	32	3	european	european	ADJ
dpc-5612	32	4	guidelines	guideline	NOUN
dpc-5612	32	5	,	,	PUNCT
dpc-5612	32	6	it	it	PRON
dpc-5612	32	7	is	be	AUX
dpc-5612	32	8	typically	typically	ADV
dpc-5612	32	9	reserved	reserve	VERB
dpc-5612	32	10	for	for	ADP
dpc-5612	32	11	severe	severe	ADJ
dpc-5612	32	12	papulopustular	papulopustular	ADJ
dpc-5612	32	13	or	or	CCONJ
dpc-5612	32	14	moderate	moderate	ADJ
dpc-5612	32	15	nodular	nodular	ADJ
dpc-5612	32	16	acne	acne	NOUN
dpc-5612	32	17	as	as	ADV
dpc-5612	32	18	well	well	ADV
dpc-5612	32	19	as	as	ADP
dpc-5612	32	20	for	for	ADP
dpc-5612	32	21	acne	acne	NOUN
dpc-5612	32	22	that	that	PRON
dpc-5612	32	23	has	have	AUX
dpc-5612	32	24	not	not	PART
dpc-5612	32	25	responded	respond	VERB
dpc-5612	32	26	to	to	ADP
dpc-5612	32	27	oral	oral	ADJ
dpc-5612	32	28	antibiotics	antibiotic	NOUN
dpc-5612	32	29	and	and	CCONJ
dpc-5612	32	30	topical	topical	ADJ
dpc-5612	32	31	treatments	treatment	NOUN
dpc-5612	32	32	[	[	X
dpc-5612	32	33	3	3	NUM
dpc-5612	32	34	]	]	PUNCT
dpc-5612	32	35	.	.	PUNCT
dpc-5612	33	1	despite	despite	SCONJ
dpc-5612	33	2	its	its	PRON
dpc-5612	33	3	efficacy	efficacy	NOUN
dpc-5612	33	4	,	,	PUNCT
dpc-5612	33	5	dermatologists	dermatologist	NOUN
dpc-5612	33	6	are	be	AUX
dpc-5612	33	7	often	often	ADV
dpc-5612	33	8	hesitant	hesitant	ADJ
dpc-5612	33	9	to	to	PART
dpc-5612	33	10	prescribe	prescribe	VERB
dpc-5612	33	11	oral	oral	ADJ
dpc-5612	33	12	isotretinoin	isotretinoin	PROPN
dpc-5612	33	13	due	due	ADP
dpc-5612	33	14	to	to	ADP
dpc-5612	33	15	its	its	PRON
dpc-5612	33	16	well	well	ADV
dpc-5612	33	17	-	-	PUNCT
dpc-5612	33	18	documented	document	VERB
dpc-5612	33	19	side	side	NOUN
dpc-5612	33	20	effects	effect	NOUN
dpc-5612	33	21	.	.	PUNCT
dpc-5612	34	1	the	the	DET
dpc-5612	34	2	most	most	ADV
dpc-5612	34	3	significant	significant	ADJ
dpc-5612	34	4	,	,	PUNCT
dpc-5612	34	5	and	and	CCONJ
dpc-5612	34	6	not	not	PART
dpc-5612	34	7	dose	dose	VERB
dpc-5612	34	8	-	-	PUNCT
dpc-5612	34	9	dependent	dependent	ADJ
dpc-5612	34	10	,	,	PUNCT
dpc-5612	34	11	extracutaneous	extracutaneous	ADJ
dpc-5612	34	12	side	side	NOUN
dpc-5612	34	13	effect	effect	NOUN
dpc-5612	34	14	is	be	AUX
dpc-5612	34	15	teratogenicity	teratogenicity	NOUN
dpc-5612	34	16	,	,	PUNCT
dpc-5612	34	17	necessitating	necessitate	VERB
dpc-5612	34	18	the	the	DET
dpc-5612	34	19	use	use	NOUN
dpc-5612	34	20	of	of	ADP
dpc-5612	34	21	effective	effective	ADJ
dpc-5612	34	22	contraception	contraception	NOUN
dpc-5612	34	23	in	in	ADP
dpc-5612	34	24	females	female	NOUN
dpc-5612	34	25	of	of	ADP
dpc-5612	34	26	childbearing	childbeare	VERB
dpc-5612	34	27	age	age	NOUN
dpc-5612	34	28	,	,	PUNCT
dpc-5612	34	29	along	along	ADP
dpc-5612	34	30	with	with	ADP
dpc-5612	34	31	monthly	monthly	ADJ
dpc-5612	34	32	pregnancy	pregnancy	NOUN
dpc-5612	34	33	tests	test	NOUN
dpc-5612	34	34	[	[	X
dpc-5612	34	35	4	4	NUM
dpc-5612	34	36	]	]	PUNCT
dpc-5612	34	37	.	.	PUNCT
dpc-5612	35	1	common	common	ADJ
dpc-5612	35	2	and	and	CCONJ
dpc-5612	35	3	dose	dose	NOUN
dpc-5612	35	4	-	-	PUNCT
dpc-5612	35	5	dependent	dependent	ADJ
dpc-5612	35	6	cutaneous	cutaneous	ADJ
dpc-5612	35	7	side	side	NOUN
dpc-5612	35	8	effects	effect	NOUN
dpc-5612	35	9	include	include	VERB
dpc-5612	35	10	dryness	dryness	NOUN
dpc-5612	35	11	of	of	ADP
dpc-5612	35	12	the	the	DET
dpc-5612	35	13	skin	skin	NOUN
dpc-5612	35	14	,	,	PUNCT
dpc-5612	35	15	lips	lip	NOUN
dpc-5612	35	16	,	,	PUNCT
dpc-5612	35	17	and	and	CCONJ
dpc-5612	35	18	eyes	eye	NOUN
dpc-5612	35	19	,	,	PUNCT
dpc-5612	35	20	which	which	PRON
dpc-5612	35	21	may	may	AUX
dpc-5612	35	22	cause	cause	VERB
dpc-5612	35	23	discomfort	discomfort	NOUN
dpc-5612	35	24	and	and	CCONJ
dpc-5612	35	25	require	require	VERB
dpc-5612	35	26	the	the	DET
dpc-5612	35	27	use	use	NOUN
dpc-5612	35	28	of	of	ADP
dpc-5612	35	29	moisturizers	moisturizer	NOUN
dpc-5612	35	30	or	or	CCONJ
dpc-5612	35	31	eye	eye	NOUN
dpc-5612	35	32	drops	drop	NOUN
dpc-5612	35	33	[	[	X
dpc-5612	35	34	5	5	NUM
dpc-5612	35	35	]	]	PUNCT
dpc-5612	35	36	.	.	PUNCT
dpc-5612	36	1	photosensitivity	photosensitivity	NOUN
dpc-5612	36	2	is	be	AUX
dpc-5612	36	3	listed	list	VERB
dpc-5612	36	4	as	as	ADP
dpc-5612	36	5	a	a	DET
dpc-5612	36	6	potential	potential	ADJ
dpc-5612	36	7	side	side	NOUN
dpc-5612	36	8	effect	effect	NOUN
dpc-5612	36	9	in	in	ADP
dpc-5612	36	10	the	the	DET
dpc-5612	36	11	technical	technical	ADJ
dpc-5612	36	12	data	datum	NOUN
dpc-5612	36	13	sheets	sheet	NOUN
dpc-5612	36	14	,	,	PUNCT
dpc-5612	36	15	recommending	recommend	VERB
dpc-5612	36	16	limited	limited	ADJ
dpc-5612	36	17	exposure	exposure	NOUN
dpc-5612	36	18	to	to	ADP
dpc-5612	36	19	ultraviolet	ultraviolet	NOUN
dpc-5612	36	20	(	(	PUNCT
dpc-5612	36	21	uv	uv	NOUN
dpc-5612	36	22	)	)	PUNCT
dpc-5612	36	23	radiation	radiation	NOUN
dpc-5612	36	24	and	and	CCONJ
dpc-5612	36	25	the	the	DET
dpc-5612	36	26	use	use	NOUN
dpc-5612	36	27	of	of	ADP
dpc-5612	36	28	protective	protective	ADJ
dpc-5612	36	29	measures	measure	NOUN
dpc-5612	36	30	such	such	ADJ
dpc-5612	36	31	as	as	ADP
dpc-5612	36	32	long	long	ADJ
dpc-5612	36	33	clothing	clothing	NOUN
dpc-5612	36	34	,	,	PUNCT
dpc-5612	36	35	hats	hat	NOUN
dpc-5612	36	36	,	,	PUNCT
dpc-5612	36	37	and	and	CCONJ
dpc-5612	36	38	high	high	ADJ
dpc-5612	36	39	spf	spf	NOUN
dpc-5612	36	40	sunscreen	sunscreen	NOUN
dpc-5612	36	41	along	along	ADP
dpc-5612	36	42	with	with	ADP
dpc-5612	36	43	the	the	DET
dpc-5612	36	44	personalization	personalization	NOUN
dpc-5612	36	45	of	of	ADP
dpc-5612	36	46	the	the	DET
dpc-5612	36	47	dosage	dosage	NOUN
dpc-5612	36	48	.	.	PUNCT
dpc-5612	37	1	however	however	ADV
dpc-5612	37	2	,	,	PUNCT
dpc-5612	37	3	the	the	DET
dpc-5612	37	4	available	available	ADJ
dpc-5612	37	5	evidence	evidence	NOUN
dpc-5612	37	6	on	on	ADP
dpc-5612	37	7	isotretinoin	isotretinoin	PROPN
dpc-5612	37	8	photosensitivity	photosensitivity	NOUN
dpc-5612	37	9	is	be	AUX
dpc-5612	37	10	outdated	outdated	ADJ
dpc-5612	37	11	and	and	CCONJ
dpc-5612	37	12	often	often	ADV
dpc-5612	37	13	contradictory	contradictory	ADJ
dpc-5612	37	14	.	.	PUNCT
dpc-5612	38	1	only	only	ADV
dpc-5612	38	2	a	a	DET
dpc-5612	38	3	few	few	ADJ
dpc-5612	38	4	cases	case	NOUN
dpc-5612	38	5	,	,	PUNCT
dpc-5612	38	6	a	a	DET
dpc-5612	38	7	long	long	ADJ
dpc-5612	38	8	-	-	PUNCT
dpc-5612	38	9	time	time	NOUN
dpc-5612	38	10	ago	ago	ADV
dpc-5612	38	11	,	,	PUNCT
dpc-5612	38	12	reported	report	VERB
dpc-5612	38	13	phototoxic	phototoxic	NOUN
dpc-5612	38	14	[	[	X
dpc-5612	38	15	6,7	6,7	NUM
dpc-5612	38	16	]	]	PUNCT
dpc-5612	38	17	or	or	CCONJ
dpc-5612	38	18	photoallergic	photoallergic	NOUN
dpc-5612	38	19	[	[	X
dpc-5612	38	20	8	8	NUM
dpc-5612	38	21	]	]	PUNCT
dpc-5612	38	22	mechanisms	mechanism	NOUN
dpc-5612	38	23	.	.	PUNCT
dpc-5612	39	1	immediate	immediate	ADJ
dpc-5612	39	2	-	-	PUNCT
dpc-5612	39	3	type	type	NOUN
dpc-5612	39	4	hypersensitivity	hypersensitivity	NOUN
dpc-5612	39	5	with	with	ADP
dpc-5612	39	6	ige	ige	PROPN
dpc-5612	39	7	involvement	involvement	NOUN
dpc-5612	39	8	has	have	AUX
dpc-5612	39	9	been	be	AUX
dpc-5612	39	10	suggested	suggest	VERB
dpc-5612	39	11	[	[	X
dpc-5612	39	12	9	9	NUM
dpc-5612	39	13	]	]	PUNCT
dpc-5612	39	14	.	.	PUNCT
dpc-5612	40	1	attempts	attempt	NOUN
dpc-5612	40	2	to	to	PART
dpc-5612	40	3	confirm	confirm	VERB
dpc-5612	40	4	the	the	DET
dpc-5612	40	5	allergic	allergic	ADJ
dpc-5612	40	6	mechanism	mechanism	NOUN
dpc-5612	40	7	through	through	ADP
dpc-5612	40	8	phototesting	phototesting	NOUN
dpc-5612	40	9	have	have	AUX
dpc-5612	40	10	not	not	PART
dpc-5612	40	11	demonstrated	demonstrate	VERB
dpc-5612	40	12	sunlight	sunlight	NOUN
dpc-5612	40	13	as	as	ADP
dpc-5612	40	14	the	the	DET
dpc-5612	40	15	primary	primary	ADJ
dpc-5612	40	16	cause	cause	NOUN
dpc-5612	40	17	of	of	ADP
dpc-5612	40	18	erythema	erythema	NOUN
dpc-5612	40	19	in	in	ADP
dpc-5612	40	20	patients	patient	NOUN
dpc-5612	40	21	taking	take	VERB
dpc-5612	40	22	oral	oral	ADJ
dpc-5612	40	23	isotretinoin	isotretinoin	NOUN
dpc-5612	41	1	[	[	X
dpc-5612	41	2	10	10	NUM
dpc-5612	41	3	]	]	PUNCT
dpc-5612	41	4	.	.	PUNCT
dpc-5612	42	1	moreover	moreover	ADV
dpc-5612	42	2	,	,	PUNCT
dpc-5612	42	3	studies	study	NOUN
dpc-5612	42	4	have	have	AUX
dpc-5612	42	5	shown	show	VERB
dpc-5612	42	6	no	no	DET
dpc-5612	42	7	significant	significant	ADJ
dpc-5612	42	8	changes	change	NOUN
dpc-5612	42	9	in	in	ADP
dpc-5612	42	10	the	the	DET
dpc-5612	42	11	ultraviolet	ultraviolet	NOUN
dpc-5612	42	12	a	a	DET
dpc-5612	42	13	and	and	CCONJ
dpc-5612	42	14	b	b	NOUN
dpc-5612	42	15	minimal	minimal	ADJ
dpc-5612	42	16	erythema	erythema	NOUN
dpc-5612	42	17	dose	dose	NOUN
dpc-5612	42	18	(	(	PUNCT
dpc-5612	42	19	med	med	PROPN
dpc-5612	42	20	)	)	PUNCT
dpc-5612	42	21	in	in	ADP
dpc-5612	42	22	patients	patient	NOUN
dpc-5612	42	23	using	use	VERB
dpc-5612	42	24	the	the	DET
dpc-5612	42	25	drug	drug	NOUN
dpc-5612	42	26	[	[	X
dpc-5612	42	27	11	11	NUM
dpc-5612	42	28	]	]	PUNCT
dpc-5612	42	29	.	.	PUNCT
dpc-5612	43	1	despite	despite	SCONJ
dpc-5612	43	2	that	that	PRON
dpc-5612	43	3	,	,	PUNCT
dpc-5612	43	4	there	there	PRON
dpc-5612	43	5	is	be	VERB
dpc-5612	43	6	a	a	DET
dpc-5612	43	7	widespread	widespread	ADJ
dpc-5612	43	8	clinical	clinical	ADJ
dpc-5612	43	9	practice	practice	NOUN
dpc-5612	43	10	of	of	ADP
dpc-5612	43	11	avoiding	avoid	VERB
dpc-5612	43	12	its	its	PRON
dpc-5612	43	13	administration	administration	NOUN
dpc-5612	43	14	during	during	ADP
dpc-5612	43	15	the	the	DET
dpc-5612	43	16	sunny	sunny	ADJ
dpc-5612	43	17	season	season	NOUN
dpc-5612	43	18	or	or	CCONJ
dpc-5612	43	19	temporarily	temporarily	ADV
dpc-5612	43	20	suspending	suspend	VERB
dpc-5612	43	21	treatment	treatment	NOUN
dpc-5612	43	22	during	during	ADP
dpc-5612	43	23	ongoing	ongoing	ADJ
dpc-5612	43	24	therapy	therapy	NOUN
dpc-5612	43	25	.	.	PUNCT
dpc-5612	44	1	this	this	DET
dpc-5612	44	2	approach	approach	NOUN
dpc-5612	44	3	lacks	lack	VERB
dpc-5612	44	4	solid	solid	ADJ
dpc-5612	44	5	evidence	evidence	NOUN
dpc-5612	44	6	to	to	PART
dpc-5612	44	7	support	support	VERB
dpc-5612	44	8	it	it	PRON
dpc-5612	44	9	,	,	PUNCT
dpc-5612	44	10	as	as	SCONJ
dpc-5612	44	11	no	no	DET
dpc-5612	44	12	study	study	NOUN
dpc-5612	44	13	has	have	AUX
dpc-5612	44	14	addressed	address	VERB
dpc-5612	44	15	the	the	DET
dpc-5612	44	16	use	use	NOUN
dpc-5612	44	17	of	of	ADP
dpc-5612	44	18	oral	oral	ADJ
dpc-5612	44	19	isotretinoin	isotretinoin	NOUN
dpc-5612	44	20	in	in	ADP
dpc-5612	44	21	the	the	DET
dpc-5612	44	22	summer	summer	NOUN
dpc-5612	44	23	or	or	CCONJ
dpc-5612	44	24	in	in	ADP
dpc-5612	44	25	seasons	season	NOUN
dpc-5612	44	26	with	with	ADP
dpc-5612	44	27	high	high	ADJ
dpc-5612	44	28	uv	uv	NOUN
dpc-5612	44	29	indices	index	NOUN
dpc-5612	44	30	.	.	PUNCT
dpc-5612	45	1	therefore	therefore	ADV
dpc-5612	45	2	,	,	PUNCT
dpc-5612	45	3	there	there	PRON
dpc-5612	45	4	is	be	VERB
dpc-5612	45	5	no	no	DET
dpc-5612	45	6	concrete	concrete	ADJ
dpc-5612	45	7	evidence	evidence	NOUN
dpc-5612	45	8	to	to	PART
dpc-5612	45	9	suggest	suggest	VERB
dpc-5612	45	10	that	that	SCONJ
dpc-5612	45	11	more	more	ADV
dpc-5612	45	12	frequent	frequent	ADJ
dpc-5612	45	13	or	or	CCONJ
dpc-5612	45	14	severe	severe	ADJ
dpc-5612	45	15	side	side	NOUN
dpc-5612	45	16	effects	effect	NOUN
dpc-5612	45	17	occur	occur	VERB
dpc-5612	45	18	during	during	ADP
dpc-5612	45	19	the	the	DET
dpc-5612	45	20	sunny	sunny	ADJ
dpc-5612	45	21	season	season	NOUN
dpc-5612	45	22	compared	compare	VERB
dpc-5612	45	23	to	to	ADP
dpc-5612	45	24	other	other	ADJ
dpc-5612	45	25	times	time	NOUN
dpc-5612	45	26	of	of	ADP
dpc-5612	45	27	the	the	DET
dpc-5612	45	28	year	year	NOUN
dpc-5612	45	29	.	.	PUNCT
dpc-5612	46	1	objectives	objective	NOUN
dpc-5612	46	2	in	in	ADP
dpc-5612	46	3	our	our	PRON
dpc-5612	46	4	clinical	clinical	ADJ
dpc-5612	46	5	practice	practice	NOUN
dpc-5612	46	6	,	,	PUNCT
dpc-5612	46	7	we	we	PRON
dpc-5612	46	8	do	do	AUX
dpc-5612	46	9	not	not	PART
dpc-5612	46	10	suspend	suspend	VERB
dpc-5612	46	11	or	or	CCONJ
dpc-5612	46	12	delay	delay	VERB
dpc-5612	46	13	the	the	DET
dpc-5612	46	14	initiation	initiation	NOUN
dpc-5612	46	15	of	of	ADP
dpc-5612	46	16	oral	oral	ADJ
dpc-5612	46	17	isotretinoin	isotretinoin	PROPN
dpc-5612	46	18	treatment	treatment	NOUN
dpc-5612	46	19	during	during	ADP
dpc-5612	46	20	the	the	DET
dpc-5612	46	21	sunny	sunny	ADJ
dpc-5612	46	22	months	month	NOUN
dpc-5612	46	23	.	.	PUNCT
dpc-5612	47	1	however	however	ADV
dpc-5612	47	2	,	,	PUNCT
dpc-5612	47	3	we	we	PRON
dpc-5612	47	4	have	have	AUX
dpc-5612	47	5	found	find	VERB
dpc-5612	47	6	that	that	SCONJ
dpc-5612	47	7	reducing	reduce	VERB
dpc-5612	47	8	its	its	PRON
dpc-5612	47	9	daily	daily	ADJ
dpc-5612	47	10	dosage	dosage	NOUN
dpc-5612	47	11	can	can	AUX
dpc-5612	47	12	be	be	AUX
dpc-5612	47	13	beneficial	beneficial	ADJ
dpc-5612	47	14	.	.	PUNCT
dpc-5612	48	1	this	this	DET
dpc-5612	48	2	precaution	precaution	NOUN
dpc-5612	48	3	is	be	AUX
dpc-5612	48	4	based	base	VERB
dpc-5612	48	5	on	on	ADP
dpc-5612	48	6	oral	oral	ADJ
dpc-5612	48	7	isotretinoin	isotretinoin	PROPN
dpc-5612	48	8	's	's	PART
dpc-5612	48	9	effect	effect	NOUN
dpc-5612	48	10	on	on	ADP
dpc-5612	48	11	the	the	DET
dpc-5612	48	12	skin	skin	NOUN
dpc-5612	48	13	,	,	PUNCT
dpc-5612	48	14	including	include	VERB
dpc-5612	48	15	the	the	DET
dpc-5612	48	16	reduction	reduction	NOUN
dpc-5612	48	17	of	of	ADP
dpc-5612	48	18	the	the	DET
dpc-5612	48	19	lipid	lipid	NOUN
dpc-5612	48	20	film	film	NOUN
dpc-5612	48	21	and	and	CCONJ
dpc-5612	48	22	thinning	thinning	NOUN
dpc-5612	48	23	of	of	ADP
dpc-5612	48	24	the	the	DET
dpc-5612	48	25	stratum	stratum	NOUN
dpc-5612	48	26	corneum	corneum	NOUN
dpc-5612	48	27	,	,	PUNCT
dpc-5612	48	28	which	which	PRON
dpc-5612	48	29	may	may	AUX
dpc-5612	48	30	increase	increase	VERB
dpc-5612	48	31	its	its	PRON
dpc-5612	48	32	vulnerability	vulnerability	NOUN
dpc-5612	48	33	to	to	ADP
dpc-5612	48	34	external	external	ADJ
dpc-5612	48	35	factors	factor	NOUN
dpc-5612	48	36	,	,	PUNCT
dpc-5612	48	37	including	include	VERB
dpc-5612	48	38	solar	solar	ADJ
dpc-5612	48	39	radiation	radiation	NOUN
dpc-5612	48	40	.	.	PUNCT
dpc-5612	49	1	the	the	DET
dpc-5612	49	2	aim	aim	NOUN
dpc-5612	49	3	of	of	ADP
dpc-5612	49	4	this	this	DET
dpc-5612	49	5	study	study	NOUN
dpc-5612	49	6	was	be	AUX
dpc-5612	49	7	to	to	PART
dpc-5612	49	8	assess	assess	VERB
dpc-5612	49	9	the	the	DET
dpc-5612	49	10	safety	safety	NOUN
dpc-5612	49	11	of	of	ADP
dpc-5612	49	12	using	use	VERB
dpc-5612	49	13	oral	oral	ADJ
dpc-5612	49	14	isotretinoin	isotretinoin	NOUN
dpc-5612	49	15	,	,	PUNCT
dpc-5612	49	16	at	at	ADP
dpc-5612	49	17	a	a	DET
dpc-5612	49	18	reduced	reduced	ADJ
dpc-5612	49	19	daily	daily	ADJ
dpc-5612	49	20	dosage	dosage	NOUN
dpc-5612	49	21	,	,	PUNCT
dpc-5612	49	22	during	during	ADP
dpc-5612	49	23	the	the	DET
dpc-5612	49	24	sunny	sunny	ADJ
dpc-5612	49	25	season	season	NOUN
dpc-5612	49	26	in	in	ADP
dpc-5612	49	27	a	a	DET
dpc-5612	49	28	real	real	ADJ
dpc-5612	49	29	-	-	PUNCT
dpc-5612	49	30	world	world	NOUN
dpc-5612	49	31	clinical	clinical	ADJ
dpc-5612	49	32	setting	setting	NOUN
dpc-5612	49	33	.	.	PUNCT
dpc-5612	50	1	methods	method	NOUN
dpc-5612	50	2	study	study	VERB
dpc-5612	50	3	design	design	NOUN
dpc-5612	50	4	and	and	CCONJ
dpc-5612	50	5	objectives	objective	NOUN
dpc-5612	50	6	this	this	DET
dpc-5612	50	7	study	study	NOUN
dpc-5612	50	8	was	be	AUX
dpc-5612	50	9	designed	design	VERB
dpc-5612	50	10	as	as	ADP
dpc-5612	50	11	a	a	DET
dpc-5612	50	12	single	single	ADJ
dpc-5612	50	13	-	-	PUNCT
dpc-5612	50	14	center	center	NOUN
dpc-5612	50	15	,	,	PUNCT
dpc-5612	50	16	retrospective	retrospective	ADJ
dpc-5612	50	17	cohort	cohort	NOUN
dpc-5612	50	18	study	study	NOUN
dpc-5612	50	19	to	to	PART
dpc-5612	50	20	analyze	analyze	VERB
dpc-5612	50	21	the	the	DET
dpc-5612	50	22	use	use	NOUN
dpc-5612	50	23	of	of	ADP
dpc-5612	50	24	oral	oral	ADJ
dpc-5612	50	25	isotretinoin	isotretinoin	NOUN
dpc-5612	50	26	in	in	ADP
dpc-5612	50	27	acne	acne	NOUN
dpc-5612	50	28	patients	patient	NOUN
dpc-5612	50	29	during	during	ADP
dpc-5612	50	30	the	the	DET
dpc-5612	50	31	sunny	sunny	ADJ
dpc-5612	50	32	months	month	NOUN
dpc-5612	50	33	of	of	ADP
dpc-5612	50	34	the	the	DET
dpc-5612	50	35	year	year	NOUN
dpc-5612	50	36	,	,	PUNCT
dpc-5612	50	37	when	when	SCONJ
dpc-5612	50	38	administered	administer	VERB
dpc-5612	50	39	at	at	ADP
dpc-5612	50	40	a	a	DET
dpc-5612	50	41	reduced	reduced	ADJ
dpc-5612	50	42	daily	daily	ADJ
dpc-5612	50	43	dosage	dosage	NOUN
dpc-5612	50	44	.	.	PUNCT
dpc-5612	51	1	the	the	DET
dpc-5612	51	2	study	study	NOUN
dpc-5612	51	3	was	be	AUX
dpc-5612	51	4	conducted	conduct	VERB
dpc-5612	51	5	in	in	ADP
dpc-5612	51	6	a	a	DET
dpc-5612	51	7	geographic	geographic	ADJ
dpc-5612	51	8	region	region	NOUN
dpc-5612	51	9	where	where	SCONJ
dpc-5612	51	10	the	the	DET
dpc-5612	51	11	uv	uv	NOUN
dpc-5612	51	12	index	index	NOUN
dpc-5612	51	13	typically	typically	ADV
dpc-5612	51	14	exceeds	exceed	VERB
dpc-5612	51	15	a	a	DET
dpc-5612	51	16	threshold	threshold	NOUN
dpc-5612	51	17	of	of	ADP
dpc-5612	51	18	6	6	NUM
dpc-5612	51	19	during	during	ADP
dpc-5612	51	20	june	june	PROPN
dpc-5612	51	21	,	,	PUNCT
dpc-5612	51	22	july	july	PROPN
dpc-5612	51	23	,	,	PUNCT
dpc-5612	51	24	august	august	PROPN
dpc-5612	51	25	,	,	PUNCT
dpc-5612	51	26	and	and	CCONJ
dpc-5612	51	27	september	september	PROPN
dpc-5612	51	28	.	.	PUNCT
dpc-5612	52	1	specifically	specifically	ADV
dpc-5612	52	2	,	,	PUNCT
dpc-5612	52	3	the	the	DET
dpc-5612	52	4	objectives	objective	NOUN
dpc-5612	52	5	of	of	ADP
dpc-5612	52	6	the	the	DET
dpc-5612	52	7	study	study	NOUN
dpc-5612	52	8	were	be	AUX
dpc-5612	52	9	to	to	PART
dpc-5612	52	10	assess	assess	VERB
dpc-5612	52	11	the	the	DET
dpc-5612	52	12	safety	safety	NOUN
dpc-5612	52	13	of	of	ADP
dpc-5612	52	14	oral	oral	ADJ
dpc-5612	52	15	isotretinoin	isotretinoin	PROPN
dpc-5612	52	16	administration	administration	NOUN
dpc-5612	52	17	during	during	ADP
dpc-5612	52	18	the	the	DET
dpc-5612	52	19	aforementioned	aforementioned	ADJ
dpc-5612	52	20	four	four	NUM
dpc-5612	52	21	sunny	sunny	ADJ
dpc-5612	52	22	months	month	NOUN
dpc-5612	52	23	and	and	CCONJ
dpc-5612	52	24	to	to	PART
dpc-5612	52	25	evaluate	evaluate	VERB
dpc-5612	52	26	the	the	DET
dpc-5612	52	27	effectiveness	effectiveness	NOUN
dpc-5612	52	28	of	of	ADP
dpc-5612	52	29	a	a	DET
dpc-5612	52	30	reduced	reduce	VERB
dpc-5612	52	31	daily	daily	ADJ
dpc-5612	52	32	dosage	dosage	NOUN
dpc-5612	52	33	regimen	regiman	NOUN
dpc-5612	52	34	of	of	ADP
dpc-5612	52	35	oral	oral	ADJ
dpc-5612	52	36	isotretinoin	isotretinoin	PROPN
dpc-5612	52	37	,	,	PUNCT
dpc-5612	52	38	tailored	tailor	VERB
dpc-5612	52	39	to	to	ADP
dpc-5612	52	40	the	the	DET
dpc-5612	52	41	sunny	sunny	ADJ
dpc-5612	52	42	season	season	NOUN
dpc-5612	52	43	.	.	PUNCT
dpc-5612	53	1	this	this	PRON
dpc-5612	53	2	was	be	AUX
dpc-5612	53	3	an	an	DET
dpc-5612	53	4	observational	observational	ADJ
dpc-5612	53	5	study	study	NOUN
dpc-5612	53	6	conducted	conduct	VERB
dpc-5612	53	7	without	without	ADP
dpc-5612	53	8	external	external	ADJ
dpc-5612	53	9	funding	funding	NOUN
dpc-5612	53	10	.	.	PUNCT
dpc-5612	54	1	all	all	DET
dpc-5612	54	2	patients	patient	NOUN
dpc-5612	54	3	treated	treat	VERB
dpc-5612	54	4	at	at	ADP
dpc-5612	54	5	our	our	PRON
dpc-5612	54	6	outpatient	outpatient	NOUN
dpc-5612	54	7	clinic	clinic	NOUN
dpc-5612	54	8	adhered	adhere	VERB
dpc-5612	54	9	to	to	ADP
dpc-5612	54	10	the	the	DET
dpc-5612	54	11	ethical	ethical	ADJ
dpc-5612	54	12	principles	principle	NOUN
dpc-5612	54	13	outlined	outline	VERB
dpc-5612	54	14	in	in	ADP
dpc-5612	54	15	the	the	DET
dpc-5612	54	16	declaration	declaration	NOUN
dpc-5612	54	17	of	of	ADP
dpc-5612	54	18	helsinki	helsinki	PROPN
dpc-5612	54	19	(	(	PUNCT
dpc-5612	54	20	1975	1975	NUM
dpc-5612	54	21	,	,	PUNCT
dpc-5612	54	22	revised	revise	VERB
dpc-5612	54	23	2013	2013	NUM
dpc-5612	54	24	)	)	PUNCT
dpc-5612	54	25	.	.	PUNCT
dpc-5612	55	1	the	the	DET
dpc-5612	55	2	study	study	NOUN
dpc-5612	55	3	was	be	AUX
dpc-5612	55	4	approved	approve	VERB
dpc-5612	55	5	by	by	ADP
dpc-5612	55	6	the	the	DET
dpc-5612	55	7	comitato	comitato	PROPN
dpc-5612	55	8	etico	etico	PROPN
dpc-5612	55	9	area	area	NOUN
dpc-5612	55	10	vasta	vasta	PROPN
dpc-5612	55	11	centro	centro	PROPN
dpc-5612	55	12	della	della	PROPN
dpc-5612	55	13	regione	regione	PROPN
dpc-5612	55	14	emilia	emilia	PROPN
dpc-5612	55	15	-	-	PUNCT
dpc-5612	55	16	romagna	romagna	PROPN
dpc-5612	55	17	(	(	PUNCT
dpc-5612	55	18	ce	ce	PROPN
dpc-5612	55	19	-	-	PUNCT
dpc-5612	55	20	avec	avec	X
dpc-5612	55	21	)	)	PUNCT
dpc-5612	55	22	(	(	PUNCT
dpc-5612	55	23	protocol	protocol	NOUN
dpc-5612	55	24	number	number	NOUN
dpc-5612	55	25	395/2024/	395/2024/	PROPN
dpc-5612	55	26	oss	oss	PROPN
dpc-5612	55	27	/	/	SYM
dpc-5612	55	28	aoufe	aoufe	NOUN
dpc-5612	55	29	,	,	PUNCT
dpc-5612	55	30	approval	approval	NOUN
dpc-5612	55	31	date	date	NOUN
dpc-5612	55	32	:	:	PUNCT
dpc-5612	55	33	18/07/2024	18/07/2024	NUM
dpc-5612	55	34	)	)	PUNCT
dpc-5612	55	35	and	and	CCONJ
dpc-5612	55	36	by	by	ADP
dpc-5612	55	37	the	the	DET
dpc-5612	55	38	ethics	ethic	NOUN
dpc-5612	55	39	committees	committee	NOUN
dpc-5612	55	40	at	at	ADP
dpc-5612	55	41	all	all	DET
dpc-5612	55	42	participating	participate	VERB
dpc-5612	55	43	sites	site	NOUN
dpc-5612	55	44	.	.	PUNCT
dpc-5612	56	1	written	write	VERB
dpc-5612	56	2	informed	informed	ADJ
dpc-5612	56	3	consent	consent	NOUN
dpc-5612	56	4	was	be	AUX
dpc-5612	56	5	obtained	obtain	VERB
dpc-5612	56	6	from	from	ADP
dpc-5612	56	7	all	all	DET
dpc-5612	56	8	patients	patient	NOUN
dpc-5612	56	9	.	.	PUNCT
dpc-5612	57	1	a	a	DET
dpc-5612	57	2	waiver	waiver	NOUN
dpc-5612	57	3	of	of	ADP
dpc-5612	57	4	informed	informed	ADJ
dpc-5612	57	5	consent	consent	NOUN
dpc-5612	57	6	was	be	AUX
dpc-5612	57	7	granted	grant	VERB
dpc-5612	57	8	for	for	ADP
dpc-5612	57	9	patients	patient	NOUN
dpc-5612	57	10	who	who	PRON
dpc-5612	57	11	could	could	AUX
dpc-5612	57	12	not	not	PART
dpc-5612	57	13	be	be	AUX
dpc-5612	57	14	traced	trace	VERB
dpc-5612	57	15	and	and	CCONJ
dpc-5612	57	16	for	for	ADP
dpc-5612	57	17	whom	whom	PRON
dpc-5612	57	18	obtaining	obtain	VERB
dpc-5612	57	19	consent	consent	NOUN
dpc-5612	57	20	was	be	AUX
dpc-5612	57	21	not	not	PART
dpc-5612	57	22	feasible	feasible	ADJ
dpc-5612	57	23	.	.	PUNCT
dpc-5612	58	1	adherence	adherence	NOUN
dpc-5612	58	2	to	to	ADP
dpc-5612	58	3	the	the	DET
dpc-5612	58	4	strobe	strobe	NOUN
dpc-5612	58	5	checklist	checklist	NOUN
dpc-5612	58	6	for	for	ADP
dpc-5612	58	7	observational	observational	ADJ
dpc-5612	58	8	studies	study	NOUN
dpc-5612	58	9	is	be	AUX
dpc-5612	58	10	summarized	summarize	VERB
dpc-5612	58	11	in	in	ADP
dpc-5612	58	12	table	table	NOUN
dpc-5612	58	13	s1	s1	NOUN
dpc-5612	58	14	.	.	PUNCT
dpc-5612	59	1	study	study	NOUN
dpc-5612	59	2	patients	patient	NOUN
dpc-5612	59	3	in	in	ADP
dpc-5612	59	4	our	our	PRON
dpc-5612	59	5	clinical	clinical	ADJ
dpc-5612	59	6	practice	practice	NOUN
dpc-5612	59	7	,	,	PUNCT
dpc-5612	59	8	acne	acne	NOUN
dpc-5612	59	9	patients	patient	NOUN
dpc-5612	59	10	are	be	AUX
dpc-5612	59	11	offered	offer	VERB
dpc-5612	59	12	treatment	treatment	NOUN
dpc-5612	59	13	with	with	ADP
dpc-5612	59	14	oral	oral	ADJ
dpc-5612	59	15	isotretinoin	isotretinoin	NOUN
dpc-5612	59	16	when	when	SCONJ
dpc-5612	59	17	they	they	PRON
dpc-5612	59	18	fail	fail	VERB
dpc-5612	59	19	to	to	PART
dpc-5612	59	20	respond	respond	VERB
dpc-5612	59	21	to	to	ADP
dpc-5612	59	22	prior	prior	ADJ
dpc-5612	59	23	conventional	conventional	ADJ
dpc-5612	59	24	combined	combine	VERB
dpc-5612	59	25	therapies	therapy	NOUN
dpc-5612	59	26	,	,	PUNCT
dpc-5612	59	27	which	which	PRON
dpc-5612	59	28	typically	typically	ADV
dpc-5612	59	29	include	include	VERB
dpc-5612	59	30	a	a	DET
dpc-5612	59	31	systemic	systemic	ADJ
dpc-5612	59	32	antibiotic	antibiotic	NOUN
dpc-5612	59	33	and	and	CCONJ
dpc-5612	59	34	a	a	DET
dpc-5612	59	35	topical	topical	ADJ
dpc-5612	59	36	agent	agent	NOUN
dpc-5612	59	37	,	,	PUNCT
dpc-5612	59	38	or	or	CCONJ
dpc-5612	59	39	in	in	ADP
dpc-5612	59	40	cases	case	NOUN
dpc-5612	59	41	of	of	ADP
dpc-5612	59	42	acne	acne	NOUN
dpc-5612	59	43	relapse	relapse	NOUN
dpc-5612	59	44	after	after	ADP
dpc-5612	59	45	discontinuation	discontinuation	NOUN
dpc-5612	59	46	of	of	ADP
dpc-5612	59	47	first	first	ADJ
dpc-5612	59	48	-	-	PUNCT
dpc-5612	59	49	line	line	NOUN
dpc-5612	59	50	treatments	treatment	NOUN
dpc-5612	59	51	.	.	PUNCT
dpc-5612	60	1	all	all	DET
dpc-5612	60	2	acne	acne	NOUN
dpc-5612	60	3	patients	patient	NOUN
dpc-5612	60	4	treated	treat	VERB
dpc-5612	60	5	with	with	ADP
dpc-5612	60	6	oral	oral	ADJ
dpc-5612	60	7	isotretinoin	isotretinoin	NOUN
dpc-5612	60	8	between	between	ADP
dpc-5612	60	9	january	january	PROPN
dpc-5612	60	10	2014	2014	NUM
dpc-5612	60	11	and	and	CCONJ
dpc-5612	60	12	december	december	PROPN
dpc-5612	60	13	2023	2023	NUM
dpc-5612	60	14	at	at	ADP
dpc-5612	60	15	the	the	DET
dpc-5612	60	16	acne	acne	NOUN
dpc-5612	60	17	clinic	clinic	NOUN
dpc-5612	60	18	of	of	ADP
dpc-5612	60	19	the	the	DET
dpc-5612	60	20	dermatology	dermatology	NOUN
dpc-5612	60	21	unit	unit	NOUN
dpc-5612	60	22	at	at	ADP
dpc-5612	60	23	the	the	DET
dpc-5612	60	24	university	university	NOUN
dpc-5612	60	25	hospital	hospital	NOUN
dpc-5612	60	26	of	of	ADP
dpc-5612	60	27	ferrara	ferrara	NOUN
dpc-5612	60	28	(	(	PUNCT
dpc-5612	60	29	located	locate	VERB
dpc-5612	60	30	in	in	ADP
dpc-5612	60	31	northeastern	northeastern	PROPN
dpc-5612	60	32	italy	italy	PROPN
dpc-5612	60	33	)	)	PUNCT
dpc-5612	60	34	were	be	AUX
dpc-5612	60	35	retrospectively	retrospectively	ADV
dpc-5612	60	36	considered	consider	VERB
dpc-5612	60	37	for	for	ADP
dpc-5612	60	38	inclusion	inclusion	NOUN
dpc-5612	60	39	.	.	PUNCT
dpc-5612	61	1	patients	patient	NOUN
dpc-5612	61	2	were	be	AUX
dpc-5612	61	3	eligible	eligible	ADJ
dpc-5612	61	4	if	if	SCONJ
dpc-5612	61	5	they	they	PRON
dpc-5612	61	6	had	have	AUX
dpc-5612	61	7	received	receive	VERB
dpc-5612	61	8	oral	oral	ADJ
dpc-5612	61	9	isotretinoin	isotretinoin	NOUN
dpc-5612	61	10	for	for	ADP
dpc-5612	61	11	at	at	ADV
dpc-5612	61	12	least	least	ADV
dpc-5612	61	13	four	four	NUM
dpc-5612	61	14	weeks	week	NOUN
dpc-5612	61	15	between	between	ADP
dpc-5612	61	16	june	june	PROPN
dpc-5612	61	17	and	and	CCONJ
dpc-5612	61	18	september	september	PROPN
dpc-5612	61	19	,	,	PUNCT
dpc-5612	61	20	regardless	regardless	ADV
dpc-5612	61	21	of	of	ADP
dpc-5612	61	22	when	when	SCONJ
dpc-5612	61	23	the	the	DET
dpc-5612	61	24	treatment	treatment	NOUN
dpc-5612	61	25	was	be	AUX
dpc-5612	61	26	initiated	initiate	VERB
dpc-5612	61	27	or	or	CCONJ
dpc-5612	61	28	its	its	PRON
dpc-5612	61	29	overall	overall	ADJ
dpc-5612	61	30	duration	duration	NOUN
dpc-5612	61	31	.	.	PUNCT
dpc-5612	62	1	age	age	NOUN
dpc-5612	62	2	,	,	PUNCT
dpc-5612	62	3	acne	acne	NOUN
dpc-5612	62	4	severity	severity	NOUN
dpc-5612	62	5	,	,	PUNCT
dpc-5612	62	6	and	and	CCONJ
dpc-5612	62	7	whether	whether	SCONJ
dpc-5612	62	8	the	the	DET
dpc-5612	62	9	treatment	treatment	NOUN
dpc-5612	62	10	was	be	AUX
dpc-5612	62	11	the	the	DET
dpc-5612	62	12	first	first	ADJ
dpc-5612	62	13	or	or	CCONJ
dpc-5612	62	14	a	a	DET
dpc-5612	62	15	subsequent	subsequent	ADJ
dpc-5612	62	16	course	course	NOUN
dpc-5612	62	17	were	be	AUX
dpc-5612	62	18	not	not	PART
dpc-5612	62	19	used	use	VERB
dpc-5612	62	20	as	as	ADP
dpc-5612	62	21	inclusion	inclusion	NOUN
dpc-5612	62	22	criteria	criterion	NOUN
dpc-5612	62	23	.	.	PUNCT
dpc-5612	63	1	for	for	ADP
dpc-5612	63	2	recruitable	recruitable	ADJ
dpc-5612	63	3	patients	patient	NOUN
dpc-5612	63	4	who	who	PRON
dpc-5612	63	5	underwent	undergo	VERB
dpc-5612	63	6	multiple	multiple	ADJ
dpc-5612	63	7	cycles	cycle	NOUN
dpc-5612	63	8	of	of	ADP
dpc-5612	63	9	oral	oral	ADJ
dpc-5612	63	10	isotretinoin	isotretinoin	NOUN
dpc-5612	63	11	,	,	PUNCT
dpc-5612	63	12	only	only	ADV
dpc-5612	63	13	the	the	DET
dpc-5612	63	14	first	first	ADJ
dpc-5612	63	15	in	in	ADP
dpc-5612	63	16	chronological	chronological	ADJ
dpc-5612	63	17	order	order	NOUN
dpc-5612	63	18	was	be	AUX
dpc-5612	63	19	taken	take	VERB
dpc-5612	63	20	into	into	ADP
dpc-5612	63	21	consideration	consideration	NOUN
dpc-5612	63	22	.	.	PUNCT
dpc-5612	64	1	the	the	DET
dpc-5612	64	2	only	only	ADJ
dpc-5612	64	3	exclusion	exclusion	NOUN
dpc-5612	64	4	criteria	criterion	NOUN
dpc-5612	64	5	were	be	AUX
dpc-5612	64	6	refusal	refusal	NOUN
dpc-5612	64	7	to	to	PART
dpc-5612	64	8	participate	participate	VERB
dpc-5612	64	9	or	or	CCONJ
dpc-5612	64	10	incomplete	incomplete	ADJ
dpc-5612	64	11	demographic	demographic	ADJ
dpc-5612	64	12	or	or	CCONJ
dpc-5612	64	13	clinical	clinical	ADJ
dpc-5612	64	14	data	datum	NOUN
dpc-5612	64	15	.	.	PUNCT
dpc-5612	65	1	original	original	ADJ
dpc-5612	65	2	article	article	NOUN
dpc-5612	65	3	|	|	ADV
dpc-5612	65	4	dermatol	dermatol	ADJ
dpc-5612	65	5	pract	pract	NOUN
dpc-5612	65	6	concept	concept	NOUN
dpc-5612	65	7	.	.	PUNCT
dpc-5612	66	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	66	2	3	3	NUM
dpc-5612	66	3	study	study	NOUN
dpc-5612	66	4	procedures	procedure	NOUN
dpc-5612	66	5	and	and	CCONJ
dpc-5612	66	6	assessments	assessment	NOUN
dpc-5612	66	7	at	at	ADP
dpc-5612	66	8	our	our	PRON
dpc-5612	66	9	acne	acne	NOUN
dpc-5612	66	10	clinic	clinic	NOUN
dpc-5612	66	11	,	,	PUNCT
dpc-5612	66	12	the	the	DET
dpc-5612	66	13	mean	mean	ADJ
dpc-5612	66	14	daily	daily	ADJ
dpc-5612	66	15	dosage	dosage	NOUN
dpc-5612	66	16	of	of	ADP
dpc-5612	66	17	oral	oral	ADJ
dpc-5612	66	18	isotretinoin	isotretinoin	PROPN
dpc-5612	66	19	is	be	AUX
dpc-5612	66	20	between	between	ADP
dpc-5612	66	21	0.2	0.2	NUM
dpc-5612	66	22	and	and	CCONJ
dpc-5612	66	23	0.3	0.3	NUM
dpc-5612	66	24	mg	mg	PROPN
dpc-5612	66	25	/	/	SYM
dpc-5612	66	26	kg	kg	X
dpc-5612	67	1	[	[	X
dpc-5612	67	2	12	12	NUM
dpc-5612	67	3	]	]	PUNCT
dpc-5612	67	4	.	.	PUNCT
dpc-5612	68	1	initially	initially	ADV
dpc-5612	68	2	,	,	PUNCT
dpc-5612	68	3	a	a	DET
dpc-5612	68	4	daily	daily	ADJ
dpc-5612	68	5	dose	dose	NOUN
dpc-5612	68	6	of	of	ADP
dpc-5612	68	7	<	<	PROPN
dpc-5612	68	8	0.2	0.2	NUM
dpc-5612	68	9	mg	mg	NOUN
dpc-5612	68	10	/	/	SYM
dpc-5612	68	11	kg	kg	PROPN
dpc-5612	68	12	is	be	AUX
dpc-5612	68	13	administered	administer	VERB
dpc-5612	68	14	to	to	PART
dpc-5612	68	15	reduce	reduce	VERB
dpc-5612	68	16	the	the	DET
dpc-5612	68	17	potential	potential	NOUN
dpc-5612	68	18	for	for	ADP
dpc-5612	68	19	acne	acne	NOUN
dpc-5612	68	20	flare	flare	NOUN
dpc-5612	68	21	-	-	PUNCT
dpc-5612	68	22	ups	up	NOUN
dpc-5612	68	23	[	[	X
dpc-5612	68	24	13,14	13,14	NUM
dpc-5612	68	25	]	]	PUNCT
dpc-5612	68	26	,	,	PUNCT
dpc-5612	68	27	and	and	CCONJ
dpc-5612	68	28	this	this	PRON
dpc-5612	68	29	is	be	AUX
dpc-5612	68	30	gradually	gradually	ADV
dpc-5612	68	31	increased	increase	VERB
dpc-5612	68	32	over	over	ADP
dpc-5612	68	33	the	the	DET
dpc-5612	68	34	first	first	ADJ
dpc-5612	68	35	four	four	NUM
dpc-5612	68	36	weeks	week	NOUN
dpc-5612	68	37	of	of	ADP
dpc-5612	68	38	treatment	treatment	NOUN
dpc-5612	68	39	.	.	PUNCT
dpc-5612	69	1	conventionally	conventionally	ADV
dpc-5612	69	2	,	,	PUNCT
dpc-5612	69	3	the	the	DET
dpc-5612	69	4	daily	daily	ADJ
dpc-5612	69	5	dosage	dosage	NOUN
dpc-5612	69	6	is	be	AUX
dpc-5612	69	7	reduced	reduce	VERB
dpc-5612	69	8	by	by	ADP
dpc-5612	69	9	approximately	approximately	ADV
dpc-5612	69	10	half	half	NOUN
dpc-5612	69	11	during	during	ADP
dpc-5612	69	12	the	the	DET
dpc-5612	69	13	four	four	NUM
dpc-5612	69	14	sunny	sunny	ADJ
dpc-5612	69	15	months	month	NOUN
dpc-5612	69	16	,	,	PUNCT
dpc-5612	69	17	then	then	ADV
dpc-5612	69	18	increased	increase	VERB
dpc-5612	69	19	again	again	ADV
dpc-5612	69	20	in	in	ADP
dpc-5612	69	21	october	october	PROPN
dpc-5612	69	22	and	and	CCONJ
dpc-5612	69	23	the	the	DET
dpc-5612	69	24	following	following	ADJ
dpc-5612	69	25	months	month	NOUN
dpc-5612	69	26	.	.	PUNCT
dpc-5612	70	1	oral	oral	ADJ
dpc-5612	70	2	isotretinoin	isotretinoin	PROPN
dpc-5612	70	3	is	be	AUX
dpc-5612	70	4	never	never	ADV
dpc-5612	70	5	suspended	suspend	VERB
dpc-5612	70	6	a	a	DET
dpc-5612	70	7	priori	priori	NOUN
dpc-5612	70	8	during	during	ADP
dpc-5612	70	9	the	the	DET
dpc-5612	70	10	sunny	sunny	ADJ
dpc-5612	70	11	season	season	NOUN
dpc-5612	70	12	.	.	PUNCT
dpc-5612	71	1	the	the	DET
dpc-5612	71	2	severity	severity	NOUN
dpc-5612	71	3	of	of	ADP
dpc-5612	71	4	acne	acne	NOUN
dpc-5612	71	5	is	be	AUX
dpc-5612	71	6	assessed	assess	VERB
dpc-5612	71	7	using	use	VERB
dpc-5612	71	8	the	the	DET
dpc-5612	71	9	leeds	leed	NOUN
dpc-5612	71	10	revised	revise	VERB
dpc-5612	71	11	acne	acne	NOUN
dpc-5612	71	12	grading	grade	VERB
dpc-5612	71	13	system	system	NOUN
dpc-5612	71	14	[	[	X
dpc-5612	71	15	15	15	NUM
dpc-5612	71	16	]	]	X
dpc-5612	71	17	,	,	PUNCT
dpc-5612	71	18	both	both	CCONJ
dpc-5612	71	19	at	at	ADP
dpc-5612	71	20	baseline	baseline	NOUN
dpc-5612	71	21	and	and	CCONJ
dpc-5612	71	22	at	at	ADP
dpc-5612	71	23	subsequent	subsequent	ADJ
dpc-5612	71	24	control	control	NOUN
dpc-5612	71	25	visits	visit	NOUN
dpc-5612	71	26	,	,	PUNCT
dpc-5612	71	27	which	which	PRON
dpc-5612	71	28	are	be	AUX
dpc-5612	71	29	scheduled	schedule	VERB
dpc-5612	71	30	at	at	ADP
dpc-5612	71	31	12	12	NUM
dpc-5612	71	32	-	-	PUNCT
dpc-5612	71	33	week	week	NOUN
dpc-5612	71	34	intervals	interval	NOUN
dpc-5612	71	35	.	.	PUNCT
dpc-5612	72	1	liver	liver	NOUN
dpc-5612	72	2	function	function	NOUN
dpc-5612	72	3	tests	test	NOUN
dpc-5612	72	4	and	and	CCONJ
dpc-5612	72	5	lipid	lipid	NOUN
dpc-5612	72	6	profile	profile	NOUN
dpc-5612	72	7	are	be	AUX
dpc-5612	72	8	evaluated	evaluate	VERB
dpc-5612	72	9	for	for	ADP
dpc-5612	72	10	all	all	DET
dpc-5612	72	11	patients	patient	NOUN
dpc-5612	72	12	prior	prior	ADV
dpc-5612	72	13	to	to	ADP
dpc-5612	72	14	treatment	treatment	NOUN
dpc-5612	72	15	initiation	initiation	NOUN
dpc-5612	72	16	and	and	CCONJ
dpc-5612	72	17	again	again	ADV
dpc-5612	72	18	at	at	ADP
dpc-5612	72	19	six	six	NUM
dpc-5612	72	20	weeks	week	NOUN
dpc-5612	72	21	after	after	SCONJ
dpc-5612	72	22	treatment	treatment	NOUN
dpc-5612	72	23	begins	begin	VERB
dpc-5612	72	24	.	.	PUNCT
dpc-5612	73	1	these	these	DET
dpc-5612	73	2	tests	test	NOUN
dpc-5612	73	3	are	be	AUX
dpc-5612	73	4	repeated	repeat	VERB
dpc-5612	73	5	as	as	ADP
dpc-5612	73	6	needed	need	VERB
dpc-5612	73	7	throughout	throughout	ADP
dpc-5612	73	8	the	the	DET
dpc-5612	73	9	treatment	treatment	NOUN
dpc-5612	73	10	course	course	NOUN
dpc-5612	73	11	.	.	PUNCT
dpc-5612	74	1	for	for	ADP
dpc-5612	74	2	female	female	ADJ
dpc-5612	74	3	patients	patient	NOUN
dpc-5612	74	4	of	of	ADP
dpc-5612	74	5	childbearing	childbeare	VERB
dpc-5612	74	6	potential	potential	NOUN
dpc-5612	74	7	,	,	PUNCT
dpc-5612	74	8	a	a	DET
dpc-5612	74	9	pregnancy	pregnancy	NOUN
dpc-5612	74	10	test	test	NOUN
dpc-5612	74	11	is	be	AUX
dpc-5612	74	12	performed	perform	VERB
dpc-5612	74	13	before	before	ADP
dpc-5612	74	14	starting	start	VERB
dpc-5612	74	15	treatment	treatment	NOUN
dpc-5612	74	16	and	and	CCONJ
dpc-5612	74	17	monthly	monthly	ADJ
dpc-5612	74	18	thereafter	thereafter	ADV
dpc-5612	74	19	,	,	PUNCT
dpc-5612	74	20	prior	prior	ADV
dpc-5612	74	21	to	to	ADP
dpc-5612	74	22	each	each	DET
dpc-5612	74	23	prescription	prescription	NOUN
dpc-5612	74	24	.	.	PUNCT
dpc-5612	75	1	oral	oral	ADJ
dpc-5612	75	2	contraception	contraception	NOUN
dpc-5612	75	3	is	be	AUX
dpc-5612	75	4	required	require	VERB
dpc-5612	75	5	to	to	PART
dpc-5612	75	6	be	be	AUX
dpc-5612	75	7	initiated	initiate	VERB
dpc-5612	75	8	before	before	ADP
dpc-5612	75	9	starting	start	VERB
dpc-5612	75	10	treatment	treatment	NOUN
dpc-5612	75	11	and	and	CCONJ
dpc-5612	75	12	continued	continue	VERB
dpc-5612	75	13	throughout	throughout	ADP
dpc-5612	75	14	the	the	DET
dpc-5612	75	15	entire	entire	ADJ
dpc-5612	75	16	treatment	treatment	NOUN
dpc-5612	75	17	period	period	NOUN
dpc-5612	75	18	as	as	ADV
dpc-5612	75	19	well	well	ADV
dpc-5612	75	20	as	as	ADP
dpc-5612	75	21	for	for	ADP
dpc-5612	75	22	four	four	NUM
dpc-5612	75	23	weeks	week	NOUN
dpc-5612	75	24	after	after	SCONJ
dpc-5612	75	25	therapy	therapy	NOUN
dpc-5612	75	26	ends	end	VERB
dpc-5612	75	27	.	.	PUNCT
dpc-5612	76	1	all	all	DET
dpc-5612	76	2	patients	patient	NOUN
dpc-5612	76	3	receive	receive	VERB
dpc-5612	76	4	both	both	CCONJ
dpc-5612	76	5	verbal	verbal	ADJ
dpc-5612	76	6	and	and	CCONJ
dpc-5612	76	7	written	write	VERB
dpc-5612	76	8	information	information	NOUN
dpc-5612	76	9	on	on	ADP
dpc-5612	76	10	the	the	DET
dpc-5612	76	11	need	need	NOUN
dpc-5612	76	12	to	to	PART
dpc-5612	76	13	use	use	VERB
dpc-5612	76	14	emollients	emollient	NOUN
dpc-5612	76	15	for	for	ADP
dpc-5612	76	16	their	their	PRON
dpc-5612	76	17	lips	lip	NOUN
dpc-5612	76	18	and	and	CCONJ
dpc-5612	76	19	moisturizing	moisturizing	NOUN
dpc-5612	76	20	products	product	NOUN
dpc-5612	76	21	for	for	ADP
dpc-5612	76	22	their	their	PRON
dpc-5612	76	23	skin	skin	NOUN
dpc-5612	76	24	and	and	CCONJ
dpc-5612	76	25	to	to	PART
dpc-5612	76	26	adhere	adhere	VERB
dpc-5612	76	27	to	to	ADP
dpc-5612	76	28	rigorous	rigorous	ADJ
dpc-5612	76	29	photoprotection	photoprotection	NOUN
dpc-5612	76	30	during	during	ADP
dpc-5612	76	31	the	the	DET
dpc-5612	76	32	sunny	sunny	ADJ
dpc-5612	76	33	months	month	NOUN
dpc-5612	76	34	.	.	PUNCT
dpc-5612	77	1	patients	patient	NOUN
dpc-5612	77	2	can	can	AUX
dpc-5612	77	3	contact	contact	VERB
dpc-5612	77	4	the	the	DET
dpc-5612	77	5	acne	acne	NOUN
dpc-5612	77	6	clinic	clinic	NOUN
dpc-5612	77	7	at	at	ADP
dpc-5612	77	8	any	any	DET
dpc-5612	77	9	time	time	NOUN
dpc-5612	77	10	to	to	PART
dpc-5612	77	11	report	report	VERB
dpc-5612	77	12	side	side	NOUN
dpc-5612	77	13	effects	effect	NOUN
dpc-5612	77	14	,	,	PUNCT
dpc-5612	77	15	with	with	ADP
dpc-5612	77	16	a	a	DET
dpc-5612	77	17	follow	follow	VERB
dpc-5612	77	18	-	-	PUNCT
dpc-5612	77	19	up	up	ADP
dpc-5612	77	20	visit	visit	NOUN
dpc-5612	77	21	scheduled	schedule	VERB
dpc-5612	77	22	as	as	ADP
dpc-5612	77	23	necessary	necessary	ADJ
dpc-5612	77	24	.	.	PUNCT
dpc-5612	78	1	the	the	DET
dpc-5612	78	2	following	follow	VERB
dpc-5612	78	3	data	datum	NOUN
dpc-5612	78	4	were	be	AUX
dpc-5612	78	5	collected	collect	VERB
dpc-5612	78	6	from	from	ADP
dpc-5612	78	7	the	the	DET
dpc-5612	78	8	patients	patient	NOUN
dpc-5612	78	9	'	'	PART
dpc-5612	78	10	clinical	clinical	ADJ
dpc-5612	78	11	records	record	NOUN
dpc-5612	78	12	:	:	PUNCT
dpc-5612	78	13	i	i	NOUN
dpc-5612	78	14	)	)	PUNCT
dpc-5612	78	15	age	age	NOUN
dpc-5612	78	16	and	and	CCONJ
dpc-5612	78	17	sex	sex	NOUN
dpc-5612	78	18	;	;	PUNCT
dpc-5612	78	19	ii	ii	X
dpc-5612	78	20	)	)	PUNCT
dpc-5612	78	21	acne	acne	NOUN
dpc-5612	78	22	severity	severity	NOUN
dpc-5612	78	23	at	at	ADP
dpc-5612	78	24	baseline	baseline	NOUN
dpc-5612	78	25	,	,	PUNCT
dpc-5612	78	26	using	use	VERB
dpc-5612	78	27	the	the	DET
dpc-5612	78	28	leeds	leed	NOUN
dpc-5612	78	29	revised	revise	VERB
dpc-5612	78	30	acne	acne	NOUN
dpc-5612	78	31	grading	grade	VERB
dpc-5612	78	32	system	system	NOUN
dpc-5612	78	33	;	;	PUNCT
dpc-5612	78	34	iii	iii	X
dpc-5612	78	35	)	)	PUNCT
dpc-5612	78	36	acne	acne	NOUN
dpc-5612	78	37	severity	severity	NOUN
dpc-5612	78	38	at	at	ADP
dpc-5612	78	39	each	each	DET
dpc-5612	78	40	control	control	NOUN
dpc-5612	78	41	visit	visit	NOUN
dpc-5612	78	42	;	;	PUNCT
dpc-5612	78	43	iv	iv	X
dpc-5612	78	44	)	)	PUNCT
dpc-5612	78	45	daily	daily	ADJ
dpc-5612	78	46	dosage	dosage	NOUN
dpc-5612	78	47	of	of	ADP
dpc-5612	78	48	oral	oral	ADJ
dpc-5612	78	49	isotretinoin	isotretinoin	NOUN
dpc-5612	78	50	for	for	ADP
dpc-5612	78	51	each	each	DET
dpc-5612	78	52	month	month	NOUN
dpc-5612	78	53	of	of	ADP
dpc-5612	78	54	therapy	therapy	NOUN
dpc-5612	78	55	;	;	PUNCT
dpc-5612	78	56	v	v	NOUN
dpc-5612	78	57	)	)	PUNCT
dpc-5612	78	58	occurrence	occurrence	NOUN
dpc-5612	78	59	of	of	ADP
dpc-5612	78	60	clinical	clinical	ADJ
dpc-5612	78	61	side	side	NOUN
dpc-5612	78	62	effects	effect	NOUN
dpc-5612	78	63	or	or	CCONJ
dpc-5612	78	64	laboratory	laboratory	NOUN
dpc-5612	78	65	anomalies	anomaly	NOUN
dpc-5612	78	66	,	,	PUNCT
dpc-5612	78	67	specifying	specify	VERB
dpc-5612	78	68	the	the	DET
dpc-5612	78	69	month	month	NOUN
dpc-5612	78	70	of	of	ADP
dpc-5612	78	71	onset	onset	NOUN
dpc-5612	78	72	or	or	CCONJ
dpc-5612	78	73	diagnosis	diagnosis	NOUN
dpc-5612	78	74	;	;	PUNCT
dpc-5612	78	75	vi	vi	X
dpc-5612	78	76	)	)	PUNCT
dpc-5612	78	77	treatment	treatment	NOUN
dpc-5612	78	78	discontinuation	discontinuation	NOUN
dpc-5612	78	79	for	for	ADP
dpc-5612	78	80	any	any	DET
dpc-5612	78	81	reason	reason	NOUN
dpc-5612	78	82	;	;	PUNCT
dpc-5612	78	83	vii	vii	PROPN
dpc-5612	78	84	)	)	PUNCT
dpc-5612	78	85	treatment	treatment	NOUN
dpc-5612	78	86	duration	duration	NOUN
dpc-5612	78	87	in	in	ADP
dpc-5612	78	88	months	month	NOUN
dpc-5612	78	89	.	.	PUNCT
dpc-5612	79	1	all	all	DET
dpc-5612	79	2	adverse	adverse	ADJ
dpc-5612	79	3	events	event	NOUN
dpc-5612	79	4	which	which	PRON
dpc-5612	79	5	occurred	occur	VERB
dpc-5612	79	6	during	during	ADP
dpc-5612	79	7	therapy	therapy	NOUN
dpc-5612	79	8	were	be	AUX
dpc-5612	79	9	taken	take	VERB
dpc-5612	79	10	into	into	ADP
dpc-5612	79	11	account	account	NOUN
dpc-5612	79	12	,	,	PUNCT
dpc-5612	79	13	except	except	SCONJ
dpc-5612	79	14	for	for	ADP
dpc-5612	79	15	lip	lip	NOUN
dpc-5612	79	16	xerosis	xerosis	NOUN
dpc-5612	79	17	,	,	PUNCT
dpc-5612	79	18	which	which	PRON
dpc-5612	79	19	was	be	AUX
dpc-5612	79	20	excluded	exclude	VERB
dpc-5612	79	21	as	as	SCONJ
dpc-5612	79	22	it	it	PRON
dpc-5612	79	23	is	be	AUX
dpc-5612	79	24	an	an	DET
dpc-5612	79	25	expected	expect	VERB
dpc-5612	79	26	effect	effect	NOUN
dpc-5612	79	27	.	.	PUNCT
dpc-5612	80	1	sample	sample	NOUN
dpc-5612	80	2	size	size	NOUN
dpc-5612	80	3	and	and	CCONJ
dpc-5612	80	4	statistical	statistical	ADJ
dpc-5612	80	5	analysis	analysis	NOUN
dpc-5612	80	6	in	in	ADP
dpc-5612	80	7	the	the	DET
dpc-5612	80	8	literature	literature	NOUN
dpc-5612	80	9	,	,	PUNCT
dpc-5612	80	10	there	there	PRON
dpc-5612	80	11	is	be	VERB
dpc-5612	80	12	no	no	DET
dpc-5612	80	13	scientific	scientific	ADJ
dpc-5612	80	14	evidence	evidence	NOUN
dpc-5612	80	15	of	of	ADP
dpc-5612	80	16	the	the	DET
dpc-5612	80	17	seasonal	seasonal	ADJ
dpc-5612	80	18	proportion	proportion	NOUN
dpc-5612	80	19	of	of	ADP
dpc-5612	80	20	adverse	adverse	ADJ
dpc-5612	80	21	events	event	NOUN
dpc-5612	80	22	in	in	ADP
dpc-5612	80	23	patients	patient	NOUN
dpc-5612	80	24	receiving	receive	VERB
dpc-5612	80	25	oral	oral	ADJ
dpc-5612	80	26	isotretinoin	isotretinoin	NOUN
dpc-5612	80	27	.	.	PUNCT
dpc-5612	81	1	for	for	ADP
dpc-5612	81	2	the	the	DET
dpc-5612	81	3	sample	sample	NOUN
dpc-5612	81	4	size	size	NOUN
dpc-5612	81	5	calculation	calculation	NOUN
dpc-5612	81	6	,	,	PUNCT
dpc-5612	81	7	historical	historical	ADJ
dpc-5612	81	8	data	datum	NOUN
dpc-5612	81	9	of	of	ADP
dpc-5612	81	10	our	our	PRON
dpc-5612	81	11	acne	acne	NOUN
dpc-5612	81	12	clinic	clinic	NOUN
dpc-5612	81	13	were	be	AUX
dpc-5612	81	14	employed	employ	VERB
dpc-5612	81	15	:	:	PUNCT
dpc-5612	81	16	a	a	DET
dpc-5612	81	17	“	"	PUNCT
dpc-5612	81	18	seasonal	seasonal	ADJ
dpc-5612	81	19	”	"	PUNCT
dpc-5612	81	20	adverse	adverse	ADJ
dpc-5612	81	21	events	event	NOUN
dpc-5612	81	22	proportion	proportion	NOUN
dpc-5612	81	23	(	(	PUNCT
dpc-5612	81	24	sunny	sunny	ADJ
dpc-5612	81	25	period	period	NOUN
dpc-5612	81	26	from	from	ADP
dpc-5612	81	27	june	june	PROPN
dpc-5612	81	28	to	to	ADP
dpc-5612	81	29	september	september	PROPN
dpc-5612	81	30	and	and	CCONJ
dpc-5612	81	31	not	not	PART
dpc-5612	81	32	-	-	PUNCT
dpc-5612	81	33	sunny	sunny	ADJ
dpc-5612	81	34	period	period	NOUN
dpc-5612	81	35	from	from	ADP
dpc-5612	81	36	october	october	PROPN
dpc-5612	81	37	to	to	ADP
dpc-5612	81	38	may	may	AUX
dpc-5612	81	39	)	)	PUNCT
dpc-5612	81	40	of	of	ADP
dpc-5612	81	41	13.4	13.4	NUM
dpc-5612	81	42	%	%	NOUN
dpc-5612	81	43	and	and	CCONJ
dpc-5612	81	44	5.2	5.2	NUM
dpc-5612	81	45	%	%	NOUN
dpc-5612	81	46	,	,	PUNCT
dpc-5612	81	47	respectively	respectively	ADV
dpc-5612	81	48	,	,	PUNCT
dpc-5612	81	49	was	be	AUX
dpc-5612	81	50	registered	register	VERB
dpc-5612	81	51	.	.	PUNCT
dpc-5612	82	1	a	a	DET
dpc-5612	82	2	power	power	NOUN
dpc-5612	82	3	estimation	estimation	NOUN
dpc-5612	82	4	,	,	PUNCT
dpc-5612	82	5	based	base	VERB
dpc-5612	82	6	on	on	ADP
dpc-5612	82	7	the	the	DET
dpc-5612	82	8	comparison	comparison	NOUN
dpc-5612	82	9	of	of	ADP
dpc-5612	82	10	the	the	DET
dpc-5612	82	11	two	two	NUM
dpc-5612	82	12	proportions	proportion	NOUN
dpc-5612	82	13	,	,	PUNCT
dpc-5612	82	14	given	give	VERB
dpc-5612	82	15	a	a	DET
dpc-5612	82	16	level	level	NOUN
dpc-5612	82	17	α=	α=	NOUN
dpc-5612	82	18	0.05	0.05	NUM
dpc-5612	82	19	and	and	CCONJ
dpc-5612	82	20	1	1	NUM
dpc-5612	82	21	-	-	PUNCT
dpc-5612	82	22	β=	β=	NOUN
dpc-5612	82	23	0.8	0.8	NUM
dpc-5612	82	24	,	,	PUNCT
dpc-5612	82	25	allowed	allow	VERB
dpc-5612	82	26	a	a	DET
dpc-5612	82	27	sample	sample	NOUN
dpc-5612	82	28	size	size	NOUN
dpc-5612	82	29	of	of	ADP
dpc-5612	82	30	182	182	NUM
dpc-5612	82	31	patients	patient	NOUN
dpc-5612	82	32	.	.	PUNCT
dpc-5612	83	1	despite	despite	SCONJ
dpc-5612	83	2	the	the	DET
dpc-5612	83	3	fact	fact	NOUN
dpc-5612	83	4	that	that	SCONJ
dpc-5612	83	5	182	182	NUM
dpc-5612	83	6	is	be	AUX
dpc-5612	83	7	the	the	DET
dpc-5612	83	8	minimum	minimum	ADJ
dpc-5612	83	9	number	number	NOUN
dpc-5612	83	10	of	of	ADP
dpc-5612	83	11	patients	patient	NOUN
dpc-5612	83	12	to	to	PART
dpc-5612	83	13	be	be	AUX
dpc-5612	83	14	considered	consider	VERB
dpc-5612	83	15	in	in	ADP
dpc-5612	83	16	order	order	NOUN
dpc-5612	83	17	to	to	PART
dpc-5612	83	18	identify	identify	VERB
dpc-5612	83	19	a	a	DET
dpc-5612	83	20	statistically	statistically	ADV
dpc-5612	83	21	significant	significant	ADJ
dpc-5612	83	22	difference	difference	NOUN
dpc-5612	83	23	in	in	ADP
dpc-5612	83	24	terms	term	NOUN
dpc-5612	83	25	of	of	ADP
dpc-5612	83	26	seasonal	seasonal	ADJ
dpc-5612	83	27	proportion	proportion	NOUN
dpc-5612	83	28	of	of	ADP
dpc-5612	83	29	adverse	adverse	ADJ
dpc-5612	83	30	events	event	NOUN
dpc-5612	83	31	,	,	PUNCT
dpc-5612	83	32	we	we	PRON
dpc-5612	83	33	considered	consider	VERB
dpc-5612	83	34	the	the	DET
dpc-5612	83	35	entire	entire	ADJ
dpc-5612	83	36	historical	historical	ADJ
dpc-5612	83	37	cohort	cohort	NOUN
dpc-5612	83	38	of	of	ADP
dpc-5612	83	39	patients	patient	NOUN
dpc-5612	83	40	treated	treat	VERB
dpc-5612	83	41	at	at	ADP
dpc-5612	83	42	our	our	PRON
dpc-5612	83	43	acne	acne	NOUN
dpc-5612	83	44	clinic	clinic	NOUN
dpc-5612	83	45	in	in	ADP
dpc-5612	83	46	the	the	DET
dpc-5612	83	47	time	time	NOUN
dpc-5612	83	48	frame	frame	NOUN
dpc-5612	83	49	considered	consider	VERB
dpc-5612	83	50	.	.	PUNCT
dpc-5612	84	1	the	the	DET
dpc-5612	84	2	shapiro	shapiro	PROPN
dpc-5612	84	3	-	-	PUNCT
dpc-5612	84	4	wilk	wilk	NOUN
dpc-5612	84	5	test	test	NOUN
dpc-5612	84	6	was	be	AUX
dpc-5612	84	7	used	use	VERB
dpc-5612	84	8	to	to	PART
dpc-5612	84	9	check	check	VERB
dpc-5612	84	10	the	the	DET
dpc-5612	84	11	normality	normality	NOUN
dpc-5612	84	12	assumption	assumption	NOUN
dpc-5612	84	13	of	of	ADP
dpc-5612	84	14	continuous	continuous	ADJ
dpc-5612	84	15	variables	variable	NOUN
dpc-5612	84	16	.	.	PUNCT
dpc-5612	85	1	in	in	ADP
dpc-5612	85	2	the	the	DET
dpc-5612	85	3	presence	presence	NOUN
dpc-5612	85	4	of	of	ADP
dpc-5612	85	5	symmetry	symmetry	NOUN
dpc-5612	85	6	,	,	PUNCT
dpc-5612	85	7	variables	variable	NOUN
dpc-5612	85	8	were	be	AUX
dpc-5612	85	9	represented	represent	VERB
dpc-5612	85	10	with	with	ADP
dpc-5612	85	11	mean	mean	ADJ
dpc-5612	85	12	and	and	CCONJ
dpc-5612	85	13	standard	standard	ADJ
dpc-5612	85	14	deviation	deviation	NOUN
dpc-5612	85	15	(	(	PUNCT
dpc-5612	85	16	sd	sd	NOUN
dpc-5612	85	17	)	)	PUNCT
dpc-5612	85	18	or	or	CCONJ
dpc-5612	85	19	,	,	PUNCT
dpc-5612	85	20	in	in	ADP
dpc-5612	85	21	case	case	NOUN
dpc-5612	85	22	of	of	ADP
dpc-5612	85	23	asymmetry	asymmetry	NOUN
dpc-5612	85	24	with	with	ADP
dpc-5612	85	25	median	median	NOUN
dpc-5612	85	26	and	and	CCONJ
dpc-5612	85	27	quartiles	quartile	NOUN
dpc-5612	86	1	[	[	X
dpc-5612	86	2	q1	q1	NOUN
dpc-5612	86	3	q3	q3	PROPN
dpc-5612	86	4	]	]	PUNCT
dpc-5612	86	5	;	;	PUNCT
dpc-5612	86	6	categorical	categorical	ADJ
dpc-5612	86	7	data	datum	NOUN
dpc-5612	86	8	are	be	AUX
dpc-5612	86	9	expressed	express	VERB
dpc-5612	86	10	as	as	ADP
dpc-5612	86	11	absolute	absolute	ADJ
dpc-5612	86	12	values	value	NOUN
dpc-5612	86	13	and	and	CCONJ
dpc-5612	86	14	percentages	percentage	NOUN
dpc-5612	86	15	(	(	PUNCT
dpc-5612	86	16	%	%	INTJ
dpc-5612	86	17	)	)	PUNCT
dpc-5612	86	18	.	.	PUNCT
dpc-5612	87	1	the	the	DET
dpc-5612	87	2	student	student	NOUN
dpc-5612	87	3	’s	’s	PART
dpc-5612	87	4	t	t	PROPN
dpc-5612	87	5	-	-	PUNCT
dpc-5612	87	6	test	test	NOUN
dpc-5612	87	7	or	or	CCONJ
dpc-5612	87	8	mann	mann	PROPN
dpc-5612	87	9	-	-	PUNCT
dpc-5612	87	10	whitney	whitney	PROPN
dpc-5612	87	11	test	test	NOUN
dpc-5612	87	12	was	be	AUX
dpc-5612	87	13	used	use	VERB
dpc-5612	87	14	to	to	PART
dpc-5612	87	15	detect	detect	VERB
dpc-5612	87	16	possible	possible	ADJ
dpc-5612	87	17	mean	mean	NOUN
dpc-5612	87	18	or	or	CCONJ
dpc-5612	87	19	median	median	ADJ
dpc-5612	87	20	significant	significant	ADJ
dpc-5612	87	21	differences	difference	NOUN
dpc-5612	87	22	between	between	ADP
dpc-5612	87	23	the	the	DET
dpc-5612	87	24	two	two	NUM
dpc-5612	87	25	groups	group	NOUN
dpc-5612	87	26	.	.	PUNCT
dpc-5612	88	1	in	in	ADP
dpc-5612	88	2	case	case	NOUN
dpc-5612	88	3	of	of	ADP
dpc-5612	88	4	categorical	categorical	ADJ
dpc-5612	88	5	variables	variable	NOUN
dpc-5612	88	6	,	,	PUNCT
dpc-5612	88	7	χ	χ	DET
dpc-5612	88	8	2	2	NUM
dpc-5612	88	9	or	or	CCONJ
dpc-5612	88	10	exact	exact	ADJ
dpc-5612	88	11	fisher	fisher	PROPN
dpc-5612	88	12	test	test	NOUN
dpc-5612	88	13	was	be	AUX
dpc-5612	88	14	used	use	VERB
dpc-5612	88	15	.	.	PUNCT
dpc-5612	89	1	a	a	DET
dpc-5612	89	2	scatter	scatter	NOUN
dpc-5612	89	3	plot	plot	NOUN
dpc-5612	89	4	with	with	ADP
dpc-5612	89	5	an	an	DET
dpc-5612	89	6	interpolation	interpolation	NOUN
dpc-5612	89	7	line	line	NOUN
dpc-5612	89	8	is	be	AUX
dpc-5612	89	9	displayed	display	VERB
dpc-5612	89	10	to	to	PART
dpc-5612	89	11	represent	represent	VERB
dpc-5612	89	12	the	the	DET
dpc-5612	89	13	joint	joint	ADJ
dpc-5612	89	14	distribution	distribution	NOUN
dpc-5612	89	15	between	between	ADP
dpc-5612	89	16	the	the	DET
dpc-5612	89	17	differential	differential	ADJ
dpc-5612	89	18	daily	daily	ADJ
dpc-5612	89	19	mean	mean	NOUN
dpc-5612	89	20	dose	dose	NOUN
dpc-5612	89	21	(	(	PUNCT
dpc-5612	89	22	x	x	NOUN
dpc-5612	89	23	-	-	NOUN
dpc-5612	89	24	axis	axis	ADJ
dpc-5612	89	25	)	)	PUNCT
dpc-5612	89	26	and	and	CCONJ
dpc-5612	89	27	the	the	DET
dpc-5612	89	28	differential	differential	ADJ
dpc-5612	89	29	leeds	leed	NOUN
dpc-5612	89	30	scores	score	NOUN
dpc-5612	89	31	(	(	PUNCT
dpc-5612	89	32	y	y	NOUN
dpc-5612	89	33	-	-	PUNCT
dpc-5612	89	34	axis	axis	NOUN
dpc-5612	89	35	)	)	PUNCT
dpc-5612	89	36	,	,	PUNCT
dpc-5612	89	37	for	for	ADP
dpc-5612	89	38	each	each	DET
dpc-5612	89	39	site	site	NOUN
dpc-5612	89	40	(	(	PUNCT
dpc-5612	89	41	face	face	NOUN
dpc-5612	89	42	,	,	PUNCT
dpc-5612	89	43	back	back	ADV
dpc-5612	89	44	,	,	PUNCT
dpc-5612	89	45	and	and	CCONJ
dpc-5612	89	46	chest	chest	NOUN
dpc-5612	89	47	)	)	PUNCT
dpc-5612	89	48	.	.	PUNCT
dpc-5612	90	1	the	the	DET
dpc-5612	90	2	first	first	ADJ
dpc-5612	90	3	and	and	CCONJ
dpc-5612	90	4	last	last	ADJ
dpc-5612	90	5	month	month	NOUN
dpc-5612	90	6	of	of	ADP
dpc-5612	90	7	treatment	treatment	NOUN
dpc-5612	90	8	values	value	NOUN
dpc-5612	90	9	available	available	ADJ
dpc-5612	90	10	were	be	AUX
dpc-5612	90	11	used	use	VERB
dpc-5612	90	12	to	to	PART
dpc-5612	90	13	calculate	calculate	VERB
dpc-5612	90	14	the	the	DET
dpc-5612	90	15	differential	differential	NOUN
dpc-5612	90	16	in	in	ADP
dpc-5612	90	17	daily	daily	ADJ
dpc-5612	90	18	mean	mean	PROPN
dpc-5612	90	19	dose	dose	NOUN
dpc-5612	90	20	.	.	PUNCT
dpc-5612	91	1	moreover	moreover	ADV
dpc-5612	91	2	,	,	PUNCT
dpc-5612	91	3	differential	differential	ADJ
dpc-5612	91	4	values	value	NOUN
dpc-5612	91	5	in	in	ADP
dpc-5612	91	6	leeds	leed	NOUN
dpc-5612	91	7	scores	score	NOUN
dpc-5612	91	8	were	be	AUX
dpc-5612	91	9	computed	compute	VERB
dpc-5612	91	10	as	as	ADP
dpc-5612	91	11	the	the	DET
dpc-5612	91	12	difference	difference	NOUN
dpc-5612	91	13	between	between	ADP
dpc-5612	91	14	baseline	baseline	NOUN
dpc-5612	91	15	and	and	CCONJ
dpc-5612	91	16	last	last	ADJ
dpc-5612	91	17	available	available	ADJ
dpc-5612	91	18	observation	observation	NOUN
dpc-5612	91	19	.	.	PUNCT
dpc-5612	92	1	all	all	DET
dpc-5612	92	2	analyses	analysis	NOUN
dpc-5612	92	3	were	be	AUX
dpc-5612	92	4	performed	perform	VERB
dpc-5612	92	5	using	use	VERB
dpc-5612	92	6	the	the	DET
dpc-5612	92	7	software	software	NOUN
dpc-5612	92	8	rstudio	rstudio	NOUN
dpc-5612	92	9	team	team	NOUN
dpc-5612	92	10	(	(	PUNCT
dpc-5612	92	11	2020	2020	NUM
dpc-5612	92	12	)	)	PUNCT
dpc-5612	92	13	.	.	PUNCT
dpc-5612	93	1	rstudio	rstudio	NOUN
dpc-5612	93	2	:	:	PUNCT
dpc-5612	93	3	integrated	integrate	VERB
dpc-5612	93	4	development	development	NOUN
dpc-5612	93	5	for	for	ADP
dpc-5612	93	6	r.	r.	PROPN
dpc-5612	93	7	rstudio	rstudio	PROPN
dpc-5612	93	8	,	,	PUNCT
dpc-5612	93	9	pbc	pbc	PROPN
dpc-5612	93	10	,	,	PUNCT
dpc-5612	93	11	boston	boston	PROPN
dpc-5612	93	12	,	,	PUNCT
dpc-5612	93	13	ma	ma	PROPN
dpc-5612	93	14	url	url	PROPN
dpc-5612	94	1	http://www	http://www	PROPN
dpc-5612	94	2	.	.	PUNCT
dpc-5612	95	1	rstudio.com/.	rstudio.com/.	PROPN
dpc-5612	95	2	a	a	DET
dpc-5612	95	3	p	p	NOUN
dpc-5612	95	4	-	-	PUNCT
dpc-5612	95	5	value	value	NOUN
dpc-5612	95	6	of	of	ADP
dpc-5612	95	7	<	<	NOUN
dpc-5612	95	8	0.05	0.05	NUM
dpc-5612	95	9	was	be	AUX
dpc-5612	95	10	considered	consider	VERB
dpc-5612	95	11	statistically	statistically	ADV
dpc-5612	95	12	significant	significant	ADJ
dpc-5612	95	13	.	.	PUNCT
dpc-5612	96	1	results	result	VERB
dpc-5612	96	2	baseline	baseline	PROPN
dpc-5612	96	3	study	study	NOUN
dpc-5612	96	4	population	population	NOUN
dpc-5612	96	5	features	feature	VERB
dpc-5612	96	6	a	a	DET
dpc-5612	96	7	total	total	NOUN
dpc-5612	96	8	of	of	ADP
dpc-5612	96	9	359	359	NUM
dpc-5612	96	10	patients	patient	NOUN
dpc-5612	96	11	were	be	AUX
dpc-5612	96	12	included	include	VERB
dpc-5612	96	13	,	,	PUNCT
dpc-5612	96	14	of	of	ADP
dpc-5612	96	15	whom	whom	PRON
dpc-5612	96	16	61.3	61.3	NUM
dpc-5612	96	17	%	%	NOUN
dpc-5612	96	18	were	be	AUX
dpc-5612	96	19	male	male	ADJ
dpc-5612	96	20	(	(	PUNCT
dpc-5612	96	21	n=220	n=220	NOUN
dpc-5612	96	22	)	)	PUNCT
dpc-5612	96	23	and	and	CCONJ
dpc-5612	96	24	38.7	38.7	NUM
dpc-5612	96	25	%	%	NOUN
dpc-5612	96	26	were	be	AUX
dpc-5612	96	27	female	female	ADJ
dpc-5612	96	28	(	(	PUNCT
dpc-5612	96	29	n=139	n=139	NUM
dpc-5612	96	30	)	)	PUNCT
dpc-5612	96	31	(	(	PUNCT
dpc-5612	96	32	table	table	NOUN
dpc-5612	96	33	1	1	NUM
dpc-5612	96	34	)	)	PUNCT
dpc-5612	96	35	.	.	PUNCT
dpc-5612	97	1	the	the	DET
dpc-5612	97	2	median	median	ADJ
dpc-5612	97	3	age	age	NOUN
dpc-5612	97	4	of	of	ADP
dpc-5612	97	5	all	all	DET
dpc-5612	97	6	patients	patient	NOUN
dpc-5612	97	7	was	be	AUX
dpc-5612	97	8	17	17	NUM
dpc-5612	97	9	years	year	NOUN
dpc-5612	97	10	(	(	PUNCT
dpc-5612	97	11	range	range	NOUN
dpc-5612	97	12	:	:	PUNCT
dpc-5612	97	13	16.0–20.0	16.0–20.0	NUM
dpc-5612	97	14	)	)	PUNCT
dpc-5612	97	15	,	,	PUNCT
dpc-5612	97	16	with	with	ADP
dpc-5612	97	17	a	a	DET
dpc-5612	97	18	mean	mean	ADJ
dpc-5612	97	19	age	age	NOUN
dpc-5612	97	20	of	of	ADP
dpc-5612	97	21	19.0	19.0	NUM
dpc-5612	97	22	years	year	NOUN
dpc-5612	97	23	(	(	PUNCT
dpc-5612	97	24	±6.7	±6.7	PROPN
dpc-5612	97	25	)	)	PUNCT
dpc-5612	97	26	.	.	PUNCT
dpc-5612	98	1	male	male	ADJ
dpc-5612	98	2	patients	patient	NOUN
dpc-5612	98	3	were	be	AUX
dpc-5612	98	4	slightly	slightly	ADV
dpc-5612	98	5	younger	young	ADJ
dpc-5612	98	6	(	(	PUNCT
dpc-5612	98	7	median	median	ADJ
dpc-5612	98	8	age	age	NOUN
dpc-5612	98	9	:	:	PUNCT
dpc-5612	98	10	17.0	17.0	NUM
dpc-5612	98	11	years	year	NOUN
dpc-5612	98	12	,	,	PUNCT
dpc-5612	98	13	range	range	NOUN
dpc-5612	98	14	:	:	PUNCT
dpc-5612	98	15	(	(	PUNCT
dpc-5612	98	16	15.0–19.0	15.0–19.0	NUM
dpc-5612	98	17	)	)	PUNCT
dpc-5612	98	18	)	)	PUNCT
dpc-5612	98	19	compared	compare	VERB
dpc-5612	98	20	to	to	ADP
dpc-5612	98	21	female	female	ADJ
dpc-5612	98	22	patients	patient	NOUN
dpc-5612	98	23	(	(	PUNCT
dpc-5612	98	24	median	median	ADJ
dpc-5612	98	25	age	age	NOUN
dpc-5612	98	26	:	:	PUNCT
dpc-5612	98	27	18.0	18.0	NUM
dpc-5612	98	28	years	year	NOUN
dpc-5612	98	29	,	,	PUNCT
dpc-5612	98	30	range	range	NOUN
dpc-5612	98	31	:	:	PUNCT
dpc-5612	98	32	(	(	PUNCT
dpc-5612	98	33	16.0–23.0	16.0–23.0	NUM
dpc-5612	98	34	)	)	PUNCT
dpc-5612	98	35	)	)	PUNCT
dpc-5612	98	36	,	,	PUNCT
dpc-5612	98	37	with	with	ADP
dpc-5612	98	38	a	a	DET
dpc-5612	98	39	difference	difference	NOUN
dpc-5612	98	40	in	in	ADP
dpc-5612	98	41	the	the	DET
dpc-5612	98	42	median	median	ADJ
dpc-5612	98	43	ages	age	NOUN
dpc-5612	98	44	(	(	PUNCT
dpc-5612	98	45	p=0.009	p=0.009	NOUN
dpc-5612	98	46	)	)	PUNCT
dpc-5612	98	47	.	.	PUNCT
dpc-5612	99	1	facial	facial	ADJ
dpc-5612	99	2	acne	acne	NOUN
dpc-5612	99	3	was	be	AUX
dpc-5612	99	4	highly	highly	ADV
dpc-5612	99	5	prevalent	prevalent	ADJ
dpc-5612	99	6	,	,	PUNCT
dpc-5612	99	7	affecting	affect	VERB
dpc-5612	99	8	98.3	98.3	NUM
dpc-5612	99	9	%	%	NOUN
dpc-5612	99	10	of	of	ADP
dpc-5612	99	11	the	the	DET
dpc-5612	99	12	entire	entire	ADJ
dpc-5612	99	13	cohort	cohort	NOUN
dpc-5612	99	14	.	.	PUNCT
dpc-5612	100	1	the	the	DET
dpc-5612	100	2	difference	difference	NOUN
dpc-5612	100	3	between	between	ADP
dpc-5612	100	4	males	male	NOUN
dpc-5612	100	5	and	and	CCONJ
dpc-5612	100	6	females	female	NOUN
dpc-5612	100	7	was	be	AUX
dpc-5612	100	8	not	not	PART
dpc-5612	100	9	significant	significant	ADJ
dpc-5612	100	10	(	(	PUNCT
dpc-5612	100	11	p=0.086	p=0.086	NOUN
dpc-5612	100	12	)	)	PUNCT
dpc-5612	100	13	as	as	SCONJ
dpc-5612	100	14	100	100	NUM
dpc-5612	100	15	%	%	NOUN
dpc-5612	100	16	of	of	ADP
dpc-5612	100	17	females	female	NOUN
dpc-5612	100	18	and	and	CCONJ
dpc-5612	100	19	97.3	97.3	NUM
dpc-5612	100	20	%	%	NOUN
dpc-5612	100	21	of	of	ADP
dpc-5612	100	22	males	male	NOUN
dpc-5612	100	23	had	have	VERB
dpc-5612	100	24	facial	facial	ADJ
dpc-5612	100	25	acne	acne	NOUN
dpc-5612	100	26	.	.	PUNCT
dpc-5612	101	1	however	however	ADV
dpc-5612	101	2	,	,	PUNCT
dpc-5612	101	3	significant	significant	ADJ
dpc-5612	101	4	sex	sex	NOUN
dpc-5612	101	5	differences	difference	NOUN
dpc-5612	101	6	were	be	AUX
dpc-5612	101	7	observed	observe	VERB
dpc-5612	101	8	in	in	ADP
dpc-5612	101	9	the	the	DET
dpc-5612	101	10	distribution	distribution	NOUN
dpc-5612	101	11	of	of	ADP
dpc-5612	101	12	truncal	truncal	ADJ
dpc-5612	101	13	acne	acne	NOUN
dpc-5612	101	14	.	.	PUNCT
dpc-5612	102	1	back	back	NOUN
dpc-5612	102	2	acne	acne	NOUN
dpc-5612	102	3	was	be	AUX
dpc-5612	102	4	present	present	ADJ
dpc-5612	102	5	in	in	ADP
dpc-5612	102	6	74.1	74.1	NUM
dpc-5612	102	7	%	%	NOUN
dpc-5612	102	8	of	of	ADP
dpc-5612	102	9	males	male	NOUN
dpc-5612	102	10	compared	compare	VERB
dpc-5612	102	11	to	to	ADP
dpc-5612	102	12	40.3	40.3	NUM
dpc-5612	102	13	%	%	NOUN
dpc-5612	102	14	of	of	ADP
dpc-5612	102	15	females	female	NOUN
dpc-5612	102	16	(	(	PUNCT
dpc-5612	102	17	p<0.001	p<0.001	PROPN
dpc-5612	102	18	)	)	PUNCT
dpc-5612	102	19	.	.	PUNCT
dpc-5612	103	1	similarly	similarly	ADV
dpc-5612	103	2	,	,	PUNCT
dpc-5612	103	3	chest	chest	NOUN
dpc-5612	103	4	acne	acne	NOUN
dpc-5612	103	5	was	be	AUX
dpc-5612	103	6	more	more	ADV
dpc-5612	103	7	common	common	ADJ
dpc-5612	103	8	in	in	ADP
dpc-5612	103	9	males	male	NOUN
dpc-5612	103	10	(	(	PUNCT
dpc-5612	103	11	38.6	38.6	NUM
dpc-5612	103	12	%	%	NOUN
dpc-5612	103	13	)	)	PUNCT
dpc-5612	103	14	than	than	ADP
dpc-5612	103	15	in	in	ADP
dpc-5612	103	16	females	female	NOUN
dpc-5612	103	17	(	(	PUNCT
dpc-5612	103	18	24.5	24.5	NUM
dpc-5612	103	19	%	%	NOUN
dpc-5612	103	20	)	)	PUNCT
dpc-5612	103	21	(	(	PUNCT
dpc-5612	103	22	p=0.008	p=0.008	NOUN
dpc-5612	103	23	)	)	PUNCT
dpc-5612	103	24	.	.	PUNCT
dpc-5612	104	1	the	the	DET
dpc-5612	104	2	severity	severity	NOUN
dpc-5612	104	3	of	of	ADP
dpc-5612	104	4	acne	acne	NOUN
dpc-5612	104	5	assessed	assess	VERB
dpc-5612	104	6	using	use	VERB
dpc-5612	104	7	the	the	DET
dpc-5612	104	8	leeds	leed	NOUN
dpc-5612	104	9	revised	revise	VERB
dpc-5612	104	10	acne	acne	NOUN
dpc-5612	104	11	grading	grade	VERB
dpc-5612	104	12	system	system	NOUN
dpc-5612	104	13	showed	show	VERB
dpc-5612	104	14	no	no	DET
dpc-5612	104	15	significant	significant	ADJ
dpc-5612	104	16	difference	difference	NOUN
dpc-5612	104	17	between	between	ADP
dpc-5612	104	18	sexes	sex	NOUN
dpc-5612	104	19	on	on	ADP
dpc-5612	104	20	the	the	DET
dpc-5612	104	21	face	face	NOUN
dpc-5612	104	22	(	(	PUNCT
dpc-5612	104	23	p=0.541	p=0.541	X
dpc-5612	104	24	)	)	PUNCT
dpc-5612	104	25	,	,	PUNCT
dpc-5612	104	26	back	back	ADV
dpc-5612	104	27	(	(	PUNCT
dpc-5612	104	28	p=0.666	p=0.666	NOUN
dpc-5612	104	29	)	)	PUNCT
dpc-5612	104	30	,	,	PUNCT
dpc-5612	104	31	or	or	CCONJ
dpc-5612	104	32	chest	chest	NOUN
dpc-5612	104	33	(	(	PUNCT
dpc-5612	104	34	p=0.199	p=0.199	NOUN
dpc-5612	104	35	)	)	PUNCT
dpc-5612	104	36	.	.	PUNCT
dpc-5612	105	1	the	the	DET
dpc-5612	105	2	median	median	ADJ
dpc-5612	105	3	duration	duration	NOUN
dpc-5612	105	4	of	of	ADP
dpc-5612	105	5	oral	oral	ADJ
dpc-5612	105	6	isotretinoin	isotretinoin	PROPN
dpc-5612	105	7	treatment	treatment	NOUN
dpc-5612	105	8	was	be	AUX
dpc-5612	105	9	10.0	10.0	NUM
dpc-5612	105	10	months	month	NOUN
dpc-5612	105	11	[	[	X
dpc-5612	105	12	8.0	8.0	NUM
dpc-5612	105	13	13.0	13.0	NUM
dpc-5612	105	14	]	]	PUNCT
dpc-5612	105	15	for	for	ADP
dpc-5612	105	16	the	the	DET
dpc-5612	105	17	entire	entire	ADJ
dpc-5612	105	18	cohort	cohort	NOUN
dpc-5612	105	19	,	,	PUNCT
dpc-5612	105	20	with	with	ADP
dpc-5612	105	21	no	no	DET
dpc-5612	105	22	significant	significant	ADJ
dpc-5612	105	23	difference	difference	NOUN
dpc-5612	105	24	between	between	ADP
dpc-5612	105	25	male	male	ADJ
dpc-5612	105	26	and	and	CCONJ
dpc-5612	105	27	female	female	ADJ
dpc-5612	105	28	patients	patient	NOUN
dpc-5612	105	29	(	(	PUNCT
dpc-5612	105	30	p=0.233	p=0.233	NUM
dpc-5612	105	31	)	)	PUNCT
dpc-5612	105	32	.	.	PUNCT
dpc-5612	106	1	4	4	NUM
dpc-5612	106	2	original	original	ADJ
dpc-5612	106	3	article	article	NOUN
dpc-5612	106	4	|	|	ADV
dpc-5612	106	5	dermatol	dermatol	ADJ
dpc-5612	106	6	pract	pract	NOUN
dpc-5612	106	7	concept	concept	NOUN
dpc-5612	106	8	.	.	PUNCT
dpc-5612	107	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	107	2	table	table	NOUN
dpc-5612	107	3	1	1	NUM
dpc-5612	107	4	.	.	PUNCT
dpc-5612	107	5	baseline	baseline	PROPN
dpc-5612	107	6	characteristics	characteristic	NOUN
dpc-5612	107	7	of	of	ADP
dpc-5612	107	8	the	the	DET
dpc-5612	107	9	study	study	NOUN
dpc-5612	107	10	patients	patient	NOUN
dpc-5612	107	11	.	.	PUNCT
dpc-5612	108	1	all	all	DET
dpc-5612	108	2	patients	patient	NOUN
dpc-5612	108	3	(	(	PUNCT
dpc-5612	108	4	n=	n=	ADJ
dpc-5612	108	5	359	359	NUM
dpc-5612	108	6	)	)	PUNCT
dpc-5612	108	7	female	female	NOUN
dpc-5612	108	8	(	(	PUNCT
dpc-5612	108	9	n=	n=	ADJ
dpc-5612	108	10	139	139	NUM
dpc-5612	108	11	)	)	PUNCT
dpc-5612	108	12	male	male	NOUN
dpc-5612	108	13	(	(	PUNCT
dpc-5612	108	14	n=	n=	ADJ
dpc-5612	108	15	220	220	NUM
dpc-5612	108	16	)	)	PUNCT
dpc-5612	108	17	p	p	NOUN
dpc-5612	108	18	-	-	PUNCT
dpc-5612	108	19	value	value	NOUN
dpc-5612	108	20	age	age	NOUN
dpc-5612	108	21	(	(	PUNCT
dpc-5612	108	22	years	year	NOUN
dpc-5612	108	23	)	)	PUNCT
dpc-5612	108	24	,	,	PUNCT
dpc-5612	108	25	median	median	PROPN
dpc-5612	108	26	[	[	X
dpc-5612	108	27	q1	q1	PROPN
dpc-5612	108	28	q3	q3	NOUN
dpc-5612	108	29	]	]	X
dpc-5612	108	30	17.0	17.0	NUM
dpc-5612	109	1	[	[	X
dpc-5612	109	2	16.0;20.0	16.0;20.0	X
dpc-5612	109	3	]	]	X
dpc-5612	109	4	18.0	18.0	NUM
dpc-5612	110	1	[	[	X
dpc-5612	110	2	16.0;23.0	16.0;23.0	NUM
dpc-5612	110	3	]	]	X
dpc-5612	110	4	17.0	17.0	NUM
dpc-5612	110	5	[	[	X
dpc-5612	110	6	15.0;19.0	15.0;19.0	NUM
dpc-5612	110	7	]	]	X
dpc-5612	110	8	0.009	0.009	NUM
dpc-5612	110	9	age	age	NOUN
dpc-5612	110	10	(	(	PUNCT
dpc-5612	110	11	years	year	NOUN
dpc-5612	110	12	)	)	PUNCT
dpc-5612	110	13	,	,	PUNCT
dpc-5612	110	14	mean	mean	INTJ
dpc-5612	110	15	(	(	PUNCT
dpc-5612	110	16	sd	sd	NOUN
dpc-5612	110	17	)	)	PUNCT
dpc-5612	110	18	19.0	19.0	NUM
dpc-5612	110	19	(	(	PUNCT
dpc-5612	110	20	6.7	6.7	NUM
dpc-5612	110	21	)	)	PUNCT
dpc-5612	110	22	19.9	19.9	NUM
dpc-5612	110	23	(	(	PUNCT
dpc-5612	110	24	6.2	6.2	NUM
dpc-5612	110	25	)	)	PUNCT
dpc-5612	110	26	18.5	18.5	NUM
dpc-5612	110	27	(	(	PUNCT
dpc-5612	110	28	6.9	6.9	NUM
dpc-5612	110	29	)	)	PUNCT
dpc-5612	110	30	0.056	0.056	NUM
dpc-5612	110	31	sex	sex	NOUN
dpc-5612	110	32	,	,	PUNCT
dpc-5612	110	33	n	n	CCONJ
dpc-5612	110	34	(	(	PUNCT
dpc-5612	110	35	%	%	INTJ
dpc-5612	110	36	)	)	PUNCT
dpc-5612	110	37	male	male	NOUN
dpc-5612	110	38	220	220	NUM
dpc-5612	110	39	(	(	PUNCT
dpc-5612	110	40	61.3	61.3	NUM
dpc-5612	110	41	%	%	NOUN
dpc-5612	110	42	)	)	PUNCT
dpc-5612	110	43	0	0	NUM
dpc-5612	110	44	220	220	NUM
dpc-5612	110	45	(	(	PUNCT
dpc-5612	110	46	100	100	NUM
dpc-5612	110	47	%	%	NOUN
dpc-5612	110	48	)	)	PUNCT
dpc-5612	110	49	female	female	ADJ
dpc-5612	110	50	139	139	NUM
dpc-5612	110	51	(	(	PUNCT
dpc-5612	110	52	38.7	38.7	NUM
dpc-5612	110	53	%	%	NOUN
dpc-5612	110	54	)	)	PUNCT
dpc-5612	110	55	139	139	NUM
dpc-5612	110	56	(	(	PUNCT
dpc-5612	110	57	100	100	NUM
dpc-5612	110	58	%	%	NOUN
dpc-5612	110	59	)	)	PUNCT
dpc-5612	110	60	0	0	NUM
dpc-5612	110	61	face	face	NOUN
dpc-5612	110	62	,	,	PUNCT
dpc-5612	110	63	presence	presence	NOUN
dpc-5612	110	64	of	of	ADP
dpc-5612	110	65	acne	acne	NOUN
dpc-5612	110	66	,	,	PUNCT
dpc-5612	110	67	n	n	CCONJ
dpc-5612	110	68	(	(	PUNCT
dpc-5612	110	69	%	%	INTJ
dpc-5612	110	70	)	)	PUNCT
dpc-5612	110	71	353	353	NUM
dpc-5612	110	72	(	(	PUNCT
dpc-5612	110	73	98.3	98.3	NUM
dpc-5612	110	74	%	%	NOUN
dpc-5612	110	75	)	)	PUNCT
dpc-5612	110	76	139	139	NUM
dpc-5612	110	77	(	(	PUNCT
dpc-5612	110	78	100.0	100.0	NUM
dpc-5612	110	79	%	%	NOUN
dpc-5612	110	80	)	)	PUNCT
dpc-5612	110	81	214	214	NUM
dpc-5612	110	82	(	(	PUNCT
dpc-5612	110	83	97.3	97.3	NUM
dpc-5612	110	84	%	%	NOUN
dpc-5612	110	85	)	)	PUNCT
dpc-5612	110	86	0.086	0.086	NUM
dpc-5612	110	87	back	back	ADV
dpc-5612	110	88	,	,	PUNCT
dpc-5612	110	89	presence	presence	NOUN
dpc-5612	110	90	of	of	ADP
dpc-5612	110	91	acne	acne	NOUN
dpc-5612	110	92	,	,	PUNCT
dpc-5612	110	93	n	n	CCONJ
dpc-5612	110	94	(	(	PUNCT
dpc-5612	110	95	%	%	INTJ
dpc-5612	110	96	)	)	PUNCT
dpc-5612	110	97	219	219	NUM
dpc-5612	110	98	(	(	PUNCT
dpc-5612	110	99	61.0	61.0	NUM
dpc-5612	110	100	%	%	NOUN
dpc-5612	110	101	)	)	PUNCT
dpc-5612	110	102	56	56	NUM
dpc-5612	110	103	(	(	PUNCT
dpc-5612	110	104	40.3	40.3	NUM
dpc-5612	110	105	%	%	NOUN
dpc-5612	110	106	)	)	PUNCT
dpc-5612	110	107	163	163	NUM
dpc-5612	110	108	(	(	PUNCT
dpc-5612	110	109	74.1	74.1	NUM
dpc-5612	110	110	%	%	NOUN
dpc-5612	110	111	)	)	PUNCT
dpc-5612	111	1	<	<	X
dpc-5612	111	2	0.001	0.001	NUM
dpc-5612	111	3	chest	chest	NOUN
dpc-5612	111	4	,	,	PUNCT
dpc-5612	111	5	presence	presence	NOUN
dpc-5612	111	6	of	of	ADP
dpc-5612	111	7	acne	acne	NOUN
dpc-5612	111	8	,	,	PUNCT
dpc-5612	111	9	n	n	CCONJ
dpc-5612	111	10	(	(	PUNCT
dpc-5612	111	11	%	%	INTJ
dpc-5612	111	12	)	)	PUNCT
dpc-5612	111	13	119	119	NUM
dpc-5612	111	14	(	(	PUNCT
dpc-5612	111	15	33.1	33.1	NUM
dpc-5612	111	16	%	%	NOUN
dpc-5612	111	17	)	)	PUNCT
dpc-5612	111	18	34	34	NUM
dpc-5612	111	19	(	(	PUNCT
dpc-5612	111	20	24.5	24.5	NUM
dpc-5612	111	21	%	%	NOUN
dpc-5612	111	22	)	)	PUNCT
dpc-5612	111	23	85	85	NUM
dpc-5612	111	24	(	(	PUNCT
dpc-5612	111	25	38.6	38.6	NUM
dpc-5612	111	26	%	%	NOUN
dpc-5612	111	27	)	)	PUNCT
dpc-5612	111	28	0.008	0.008	NUM
dpc-5612	111	29	face	face	NOUN
dpc-5612	111	30	leeds	leed	NOUN
dpc-5612	111	31	revised	revise	VERB
dpc-5612	111	32	acne	acne	NOUN
dpc-5612	111	33	grading	grade	VERB
dpc-5612	111	34	system	system	NOUN
dpc-5612	111	35	,	,	PUNCT
dpc-5612	111	36	median	median	PROPN
dpc-5612	112	1	[	[	X
dpc-5612	112	2	q1	q1	NOUN
dpc-5612	112	3	q3	q3	NOUN
dpc-5612	112	4	]	]	X
dpc-5612	112	5	3	3	NUM
dpc-5612	113	1	[	[	X
dpc-5612	113	2	2;4	2;4	NUM
dpc-5612	113	3	]	]	X
dpc-5612	113	4	3	3	NUM
dpc-5612	113	5	[	[	X
dpc-5612	113	6	2;4	2;4	NUM
dpc-5612	113	7	]	]	X
dpc-5612	113	8	3	3	NUM
dpc-5612	113	9	[	[	X
dpc-5612	113	10	2;4	2;4	NUM
dpc-5612	113	11	]	]	PUNCT
dpc-5612	113	12	0.541	0.541	NUM
dpc-5612	113	13	back	back	NOUN
dpc-5612	113	14	leeds	leed	NOUN
dpc-5612	113	15	revised	revise	VERB
dpc-5612	113	16	acne	acne	NOUN
dpc-5612	113	17	grading	grade	VERB
dpc-5612	113	18	system	system	NOUN
dpc-5612	113	19	,	,	PUNCT
dpc-5612	113	20	median	median	PROPN
dpc-5612	114	1	[	[	X
dpc-5612	114	2	q1	q1	NOUN
dpc-5612	114	3	q3	q3	NOUN
dpc-5612	114	4	]	]	X
dpc-5612	114	5	3	3	NUM
dpc-5612	115	1	[	[	X
dpc-5612	115	2	2;4	2;4	NUM
dpc-5612	115	3	]	]	X
dpc-5612	115	4	3	3	NUM
dpc-5612	115	5	[	[	X
dpc-5612	115	6	2;4	2;4	NUM
dpc-5612	115	7	]	]	X
dpc-5612	115	8	3	3	NUM
dpc-5612	115	9	[	[	X
dpc-5612	115	10	2;4	2;4	NUM
dpc-5612	115	11	]	]	X
dpc-5612	115	12	0.666	0.666	NUM
dpc-5612	115	13	chest	chest	NOUN
dpc-5612	115	14	leeds	leed	NOUN
dpc-5612	115	15	revised	revise	VERB
dpc-5612	115	16	acne	acne	NOUN
dpc-5612	115	17	grading	grade	VERB
dpc-5612	115	18	system	system	NOUN
dpc-5612	115	19	,	,	PUNCT
dpc-5612	115	20	median	median	PROPN
dpc-5612	116	1	[	[	X
dpc-5612	116	2	q1	q1	NOUN
dpc-5612	116	3	q3	q3	NOUN
dpc-5612	116	4	]	]	X
dpc-5612	116	5	2	2	NUM
dpc-5612	117	1	[	[	X
dpc-5612	117	2	1;3	1;3	NUM
dpc-5612	117	3	]	]	SYM
dpc-5612	117	4	1	1	NUM
dpc-5612	118	1	[	[	X
dpc-5612	118	2	1;2	1;2	NUM
dpc-5612	118	3	]	]	SYM
dpc-5612	118	4	2	2	NUM
dpc-5612	118	5	[	[	X
dpc-5612	118	6	1;3	1;3	NUM
dpc-5612	118	7	]	]	PUNCT
dpc-5612	118	8	0.199	0.199	NUM
dpc-5612	118	9	treatment	treatment	NOUN
dpc-5612	118	10	duration	duration	NOUN
dpc-5612	118	11	(	(	PUNCT
dpc-5612	118	12	months	month	NOUN
dpc-5612	118	13	)	)	PUNCT
dpc-5612	118	14	,	,	PUNCT
dpc-5612	119	1	median	median	PROPN
dpc-5612	119	2	[	[	X
dpc-5612	119	3	q1	q1	NOUN
dpc-5612	119	4	q3	q3	NOUN
dpc-5612	119	5	]	]	X
dpc-5612	119	6	10.0	10.0	NUM
dpc-5612	119	7	[	[	X
dpc-5612	119	8	8.0;13.0	8.0;13.0	NUM
dpc-5612	119	9	]	]	X
dpc-5612	119	10	10.0	10.0	NUM
dpc-5612	119	11	[	[	X
dpc-5612	119	12	8.0;12.0	8.0;12.0	X
dpc-5612	119	13	]	]	X
dpc-5612	119	14	10.0	10.0	NUM
dpc-5612	119	15	[	[	X
dpc-5612	119	16	8.0;14.0	8.0;14.0	X
dpc-5612	119	17	]	]	PUNCT
dpc-5612	119	18	0.233	0.233	NUM
dpc-5612	119	19	[	[	X
dpc-5612	119	20	q1	q1	NOUN
dpc-5612	119	21	q3	q3	NOUN
dpc-5612	119	22	]	]	PUNCT
dpc-5612	119	23	:	:	PUNCT
dpc-5612	119	24	first	first	ADJ
dpc-5612	119	25	and	and	CCONJ
dpc-5612	119	26	third	third	ADJ
dpc-5612	119	27	quantiles	quantile	NOUN
dpc-5612	119	28	;	;	PUNCT
dpc-5612	119	29	sd	sd	NOUN
dpc-5612	119	30	,	,	PUNCT
dpc-5612	119	31	standard	standard	ADJ
dpc-5612	119	32	deviation	deviation	NOUN
dpc-5612	119	33	.	.	PUNCT
dpc-5612	120	1	treatment	treatment	NOUN
dpc-5612	120	2	effectiveness	effectiveness	NOUN
dpc-5612	120	3	the	the	DET
dpc-5612	120	4	effectiveness	effectiveness	NOUN
dpc-5612	120	5	of	of	ADP
dpc-5612	120	6	oral	oral	ADJ
dpc-5612	120	7	isotretinoin	isotretinoin	PROPN
dpc-5612	120	8	treatment	treatment	NOUN
dpc-5612	120	9	was	be	AUX
dpc-5612	120	10	assessed	assess	VERB
dpc-5612	120	11	by	by	ADP
dpc-5612	120	12	comparing	compare	VERB
dpc-5612	120	13	acne	acne	NOUN
dpc-5612	120	14	severity	severity	NOUN
dpc-5612	120	15	scores	score	NOUN
dpc-5612	120	16	before	before	ADP
dpc-5612	120	17	treatment	treatment	NOUN
dpc-5612	120	18	and	and	CCONJ
dpc-5612	120	19	at	at	ADP
dpc-5612	120	20	its	its	PRON
dpc-5612	120	21	completion	completion	NOUN
dpc-5612	120	22	using	use	VERB
dpc-5612	120	23	the	the	DET
dpc-5612	120	24	leeds	leed	NOUN
dpc-5612	120	25	revised	revise	VERB
dpc-5612	120	26	acne	acne	NOUN
dpc-5612	120	27	grading	grade	VERB
dpc-5612	120	28	system	system	NOUN
dpc-5612	120	29	(	(	PUNCT
dpc-5612	120	30	table	table	NOUN
dpc-5612	120	31	2	2	NUM
dpc-5612	120	32	)	)	PUNCT
dpc-5612	120	33	.	.	PUNCT
dpc-5612	121	1	a	a	DET
dpc-5612	121	2	total	total	NOUN
dpc-5612	121	3	of	of	ADP
dpc-5612	121	4	352	352	NUM
dpc-5612	121	5	patients	patient	NOUN
dpc-5612	121	6	were	be	AUX
dpc-5612	121	7	evaluated	evaluate	VERB
dpc-5612	121	8	for	for	ADP
dpc-5612	121	9	facial	facial	ADJ
dpc-5612	121	10	acne	acne	NOUN
dpc-5612	121	11	severity	severity	NOUN
dpc-5612	121	12	,	,	PUNCT
dpc-5612	121	13	219	219	NUM
dpc-5612	121	14	for	for	ADP
dpc-5612	121	15	back	back	ADJ
dpc-5612	121	16	acne	acne	NOUN
dpc-5612	121	17	,	,	PUNCT
dpc-5612	121	18	and	and	CCONJ
dpc-5612	121	19	118	118	NUM
dpc-5612	121	20	for	for	ADP
dpc-5612	121	21	chest	chest	NOUN
dpc-5612	121	22	acne	acne	NOUN
dpc-5612	121	23	.	.	PUNCT
dpc-5612	122	1	there	there	PRON
dpc-5612	122	2	is	be	VERB
dpc-5612	122	3	a	a	DET
dpc-5612	122	4	minor	minor	ADJ
dpc-5612	122	5	discrepancy	discrepancy	NOUN
dpc-5612	122	6	compared	compare	VERB
dpc-5612	122	7	to	to	ADP
dpc-5612	122	8	the	the	DET
dpc-5612	122	9	total	total	ADJ
dpc-5612	122	10	number	number	NOUN
dpc-5612	122	11	of	of	ADP
dpc-5612	122	12	enrolled	enrol	VERB
dpc-5612	122	13	patients	patient	NOUN
dpc-5612	122	14	,	,	PUNCT
dpc-5612	122	15	as	as	SCONJ
dpc-5612	122	16	the	the	DET
dpc-5612	122	17	number	number	NOUN
dpc-5612	122	18	of	of	ADP
dpc-5612	122	19	patients	patient	NOUN
dpc-5612	122	20	with	with	ADP
dpc-5612	122	21	facial	facial	ADJ
dpc-5612	122	22	acne	acne	NOUN
dpc-5612	122	23	and	and	CCONJ
dpc-5612	122	24	truncal	truncal	ADJ
dpc-5612	122	25	cane	cane	NOUN
dpc-5612	122	26	was	be	AUX
dpc-5612	122	27	353	353	NUM
dpc-5612	122	28	and	and	CCONJ
dpc-5612	122	29	119	119	NUM
dpc-5612	122	30	,	,	PUNCT
dpc-5612	122	31	respectively	respectively	ADV
dpc-5612	122	32	(	(	PUNCT
dpc-5612	122	33	table	table	NOUN
dpc-5612	122	34	1	1	NUM
dpc-5612	122	35	)	)	PUNCT
dpc-5612	122	36	.	.	PUNCT
dpc-5612	123	1	however	however	ADV
dpc-5612	123	2	,	,	PUNCT
dpc-5612	123	3	one	one	NUM
dpc-5612	123	4	subject	subject	NOUN
dpc-5612	123	5	did	do	AUX
dpc-5612	123	6	not	not	PART
dpc-5612	123	7	have	have	VERB
dpc-5612	123	8	a	a	DET
dpc-5612	123	9	baseline	baseline	ADJ
dpc-5612	123	10	severity	severity	NOUN
dpc-5612	123	11	score	score	NOUN
dpc-5612	123	12	recorded	record	VERB
dpc-5612	123	13	for	for	ADP
dpc-5612	123	14	the	the	DET
dpc-5612	123	15	face	face	NOUN
dpc-5612	123	16	.	.	PUNCT
dpc-5612	124	1	similarly	similarly	ADV
dpc-5612	124	2	,	,	PUNCT
dpc-5612	124	3	one	one	NUM
dpc-5612	124	4	patient	patient	NOUN
dpc-5612	124	5	with	with	ADP
dpc-5612	124	6	chest	chest	NOUN
dpc-5612	124	7	acne	acne	NOUN
dpc-5612	124	8	lacked	lack	VERB
dpc-5612	124	9	follow	follow	NOUN
dpc-5612	124	10	-	-	PUNCT
dpc-5612	124	11	up	up	ADP
dpc-5612	124	12	data	datum	NOUN
dpc-5612	124	13	for	for	ADP
dpc-5612	124	14	this	this	DET
dpc-5612	124	15	site	site	NOUN
dpc-5612	124	16	.	.	PUNCT
dpc-5612	125	1	they	they	PRON
dpc-5612	125	2	were	be	AUX
dpc-5612	125	3	therefore	therefore	ADV
dpc-5612	125	4	excluded	exclude	VERB
dpc-5612	125	5	from	from	ADP
dpc-5612	125	6	the	the	DET
dpc-5612	125	7	analyses	analysis	NOUN
dpc-5612	125	8	.	.	PUNCT
dpc-5612	126	1	for	for	ADP
dpc-5612	126	2	facial	facial	ADJ
dpc-5612	126	3	acne	acne	NOUN
dpc-5612	126	4	,	,	PUNCT
dpc-5612	126	5	the	the	DET
dpc-5612	126	6	median	median	ADJ
dpc-5612	126	7	severity	severity	NOUN
dpc-5612	126	8	score	score	NOUN
dpc-5612	126	9	significantly	significantly	ADV
dpc-5612	126	10	decreased	decrease	VERB
dpc-5612	126	11	from	from	ADP
dpc-5612	126	12	3	3	NUM
dpc-5612	126	13	(	(	PUNCT
dpc-5612	126	14	2–4	2–4	NUM
dpc-5612	126	15	)	)	PUNCT
dpc-5612	126	16	at	at	ADP
dpc-5612	126	17	baseline	baseline	NOUN
dpc-5612	126	18	to	to	ADP
dpc-5612	126	19	0	0	NUM
dpc-5612	126	20	(	(	PUNCT
dpc-5612	126	21	0–1	0–1	NOUN
dpc-5612	126	22	)	)	PUNCT
dpc-5612	126	23	after	after	ADP
dpc-5612	126	24	treatment	treatment	NOUN
dpc-5612	126	25	(	(	PUNCT
dpc-5612	126	26	p<0.001	p<0.001	PROPN
dpc-5612	126	27	)	)	PUNCT
dpc-5612	126	28	.	.	PUNCT
dpc-5612	127	1	similarly	similarly	ADV
dpc-5612	127	2	,	,	PUNCT
dpc-5612	127	3	for	for	ADP
dpc-5612	127	4	back	back	ADJ
dpc-5612	127	5	acne	acne	NOUN
dpc-5612	127	6	,	,	PUNCT
dpc-5612	127	7	the	the	DET
dpc-5612	127	8	median	median	ADJ
dpc-5612	127	9	score	score	NOUN
dpc-5612	127	10	dropped	drop	VERB
dpc-5612	127	11	from	from	ADP
dpc-5612	127	12	3	3	NUM
dpc-5612	127	13	(	(	PUNCT
dpc-5612	127	14	2–4	2–4	NUM
dpc-5612	127	15	)	)	PUNCT
dpc-5612	127	16	to	to	ADP
dpc-5612	127	17	0	0	NUM
dpc-5612	127	18	(	(	PUNCT
dpc-5612	127	19	0–1	0–1	NOUN
dpc-5612	127	20	)	)	PUNCT
dpc-5612	127	21	(	(	PUNCT
dpc-5612	127	22	p<0.001	p<0.001	PROPN
dpc-5612	127	23	)	)	PUNCT
dpc-5612	127	24	.	.	PUNCT
dpc-5612	128	1	chest	chest	PROPN
dpc-5612	128	2	acne	acne	NOUN
dpc-5612	128	3	also	also	ADV
dpc-5612	128	4	showed	show	VERB
dpc-5612	128	5	substantial	substantial	ADJ
dpc-5612	128	6	improvement	improvement	NOUN
dpc-5612	128	7	,	,	PUNCT
dpc-5612	128	8	with	with	ADP
dpc-5612	128	9	the	the	DET
dpc-5612	128	10	median	median	ADJ
dpc-5612	128	11	score	score	NOUN
dpc-5612	128	12	decreasing	decrease	VERB
dpc-5612	128	13	from	from	ADP
dpc-5612	128	14	2	2	NUM
dpc-5612	128	15	(	(	PUNCT
dpc-5612	128	16	1–3	1–3	NOUN
dpc-5612	128	17	)	)	PUNCT
dpc-5612	128	18	to	to	ADP
dpc-5612	128	19	0	0	NUM
dpc-5612	128	20	(	(	PUNCT
dpc-5612	128	21	0–1	0–1	NOUN
dpc-5612	128	22	)	)	PUNCT
dpc-5612	128	23	following	follow	VERB
dpc-5612	128	24	treatment	treatment	NOUN
dpc-5612	128	25	(	(	PUNCT
dpc-5612	128	26	p<0.001	p<0.001	PROPN
dpc-5612	128	27	)	)	PUNCT
dpc-5612	128	28	.	.	PUNCT
dpc-5612	129	1	these	these	DET
dpc-5612	129	2	results	result	NOUN
dpc-5612	129	3	show	show	VERB
dpc-5612	129	4	a	a	DET
dpc-5612	129	5	statistically	statistically	ADV
dpc-5612	129	6	significant	significant	ADJ
dpc-5612	129	7	reduction	reduction	NOUN
dpc-5612	129	8	in	in	ADP
dpc-5612	129	9	acne	acne	NOUN
dpc-5612	129	10	severity	severity	NOUN
dpc-5612	129	11	across	across	ADP
dpc-5612	129	12	all	all	DET
dpc-5612	129	13	body	body	NOUN
dpc-5612	129	14	areas	area	NOUN
dpc-5612	129	15	following	follow	VERB
dpc-5612	129	16	oral	oral	ADJ
dpc-5612	129	17	isotretinoin	isotretinoin	PROPN
dpc-5612	129	18	therapy	therapy	NOUN
dpc-5612	129	19	.	.	PUNCT
dpc-5612	130	1	seasonal	seasonal	ADJ
dpc-5612	130	2	safety	safety	NOUN
dpc-5612	130	3	of	of	ADP
dpc-5612	130	4	treatment	treatment	NOUN
dpc-5612	130	5	the	the	DET
dpc-5612	130	6	seasonal	seasonal	ADJ
dpc-5612	130	7	safety	safety	NOUN
dpc-5612	130	8	profile	profile	NOUN
dpc-5612	130	9	of	of	ADP
dpc-5612	130	10	oral	oral	ADJ
dpc-5612	130	11	isotretinoin	isotretinoin	PROPN
dpc-5612	130	12	was	be	AUX
dpc-5612	130	13	assessed	assess	VERB
dpc-5612	130	14	by	by	ADP
dpc-5612	130	15	comparing	compare	VERB
dpc-5612	130	16	the	the	DET
dpc-5612	130	17	daily	daily	ADJ
dpc-5612	130	18	dosage	dosage	NOUN
dpc-5612	130	19	,	,	PUNCT
dpc-5612	130	20	occurrence	occurrence	NOUN
dpc-5612	130	21	of	of	ADP
dpc-5612	130	22	adverse	adverse	ADJ
dpc-5612	130	23	events	event	NOUN
dpc-5612	130	24	,	,	PUNCT
dpc-5612	130	25	and	and	CCONJ
dpc-5612	130	26	treatment	treatment	NOUN
dpc-5612	130	27	discontinuation	discontinuation	NOUN
dpc-5612	130	28	rates	rate	NOUN
dpc-5612	130	29	between	between	ADP
dpc-5612	130	30	the	the	DET
dpc-5612	130	31	non	non	ADJ
dpc-5612	130	32	-	-	ADJ
dpc-5612	130	33	sunny	sunny	ADJ
dpc-5612	130	34	months	month	NOUN
dpc-5612	130	35	(	(	PUNCT
dpc-5612	130	36	october	october	NOUN
dpc-5612	130	37	to	to	PART
dpc-5612	130	38	may	may	AUX
dpc-5612	130	39	)	)	PUNCT
dpc-5612	130	40	and	and	CCONJ
dpc-5612	130	41	the	the	DET
dpc-5612	130	42	sunny	sunny	ADJ
dpc-5612	130	43	months	month	NOUN
dpc-5612	130	44	(	(	PUNCT
dpc-5612	130	45	june	june	PROPN
dpc-5612	130	46	to	to	ADP
dpc-5612	130	47	september	september	PROPN
dpc-5612	130	48	)	)	PUNCT
dpc-5612	130	49	(	(	PUNCT
dpc-5612	130	50	table	table	NOUN
dpc-5612	130	51	3	3	NUM
dpc-5612	130	52	)	)	PUNCT
dpc-5612	130	53	.	.	PUNCT
dpc-5612	131	1	the	the	DET
dpc-5612	131	2	median	median	PROPN
dpc-5612	131	3	isotretinoin	isotretinoin	PROPN
dpc-5612	131	4	dose	dose	PROPN
dpc-5612	131	5	was	be	AUX
dpc-5612	131	6	significantly	significantly	ADV
dpc-5612	131	7	lower	low	ADJ
dpc-5612	131	8	during	during	ADP
dpc-5612	131	9	the	the	DET
dpc-5612	131	10	sunny	sunny	ADJ
dpc-5612	131	11	months	month	NOUN
dpc-5612	131	12	(	(	PUNCT
dpc-5612	131	13	10.0	10.0	NUM
dpc-5612	131	14	mg	mg	NUM
dpc-5612	131	15	;	;	PUNCT
dpc-5612	131	16	(	(	PUNCT
dpc-5612	131	17	10.0	10.0	NUM
dpc-5612	131	18	–	–	SYM
dpc-5612	131	19	15.0	15.0	NUM
dpc-5612	131	20	)	)	PUNCT
dpc-5612	131	21	)	)	PUNCT
dpc-5612	131	22	compared	compare	VERB
dpc-5612	131	23	to	to	ADP
dpc-5612	131	24	the	the	DET
dpc-5612	131	25	non	non	ADJ
dpc-5612	131	26	-	-	ADJ
dpc-5612	131	27	sunny	sunny	ADJ
dpc-5612	131	28	months	month	NOUN
dpc-5612	131	29	(	(	PUNCT
dpc-5612	131	30	15.0	15.0	NUM
dpc-5612	131	31	mg	mg	NUM
dpc-5612	131	32	;	;	PUNCT
dpc-5612	131	33	(	(	PUNCT
dpc-5612	131	34	10.0–20.0	10.0–20.0	NUM
dpc-5612	131	35	)	)	PUNCT
dpc-5612	131	36	)	)	PUNCT
dpc-5612	131	37	(	(	PUNCT
dpc-5612	131	38	p<0.001	p<0.001	PROPN
dpc-5612	131	39	)	)	PUNCT
dpc-5612	131	40	.	.	PUNCT
dpc-5612	132	1	adverse	adverse	ADJ
dpc-5612	132	2	events	event	NOUN
dpc-5612	132	3	were	be	AUX
dpc-5612	132	4	reported	report	VERB
dpc-5612	132	5	by	by	ADP
dpc-5612	132	6	39.2	39.2	NUM
dpc-5612	132	7	%	%	NOUN
dpc-5612	132	8	of	of	ADP
dpc-5612	132	9	patients	patient	NOUN
dpc-5612	132	10	during	during	ADP
dpc-5612	132	11	the	the	DET
dpc-5612	132	12	non	non	ADJ
dpc-5612	132	13	-	-	ADJ
dpc-5612	132	14	sunny	sunny	ADJ
dpc-5612	132	15	months	month	NOUN
dpc-5612	132	16	,	,	PUNCT
dpc-5612	132	17	while	while	SCONJ
dpc-5612	132	18	this	this	DET
dpc-5612	132	19	figure	figure	NOUN
dpc-5612	132	20	decreased	decrease	VERB
dpc-5612	132	21	to	to	ADP
dpc-5612	132	22	28.3	28.3	NUM
dpc-5612	132	23	%	%	NOUN
dpc-5612	132	24	during	during	ADP
dpc-5612	132	25	the	the	DET
dpc-5612	132	26	sunny	sunny	ADJ
dpc-5612	132	27	months	month	NOUN
dpc-5612	132	28	(	(	PUNCT
dpc-5612	132	29	p<0.001	p<0.001	PROPN
dpc-5612	132	30	)	)	PUNCT
dpc-5612	132	31	.	.	PUNCT
dpc-5612	133	1	the	the	DET
dpc-5612	133	2	most	most	ADV
dpc-5612	133	3	frequently	frequently	ADV
dpc-5612	133	4	adverse	adverse	ADJ
dpc-5612	133	5	event	event	NOUN
dpc-5612	133	6	recorded	record	VERB
dpc-5612	133	7	was	be	AUX
dpc-5612	133	8	skin	skin	NOUN
dpc-5612	133	9	xerosis	xerosis	NOUN
dpc-5612	133	10	(	(	PUNCT
dpc-5612	133	11	212	212	NUM
dpc-5612	133	12	records	record	NOUN
dpc-5612	133	13	)	)	PUNCT
dpc-5612	133	14	,	,	PUNCT
dpc-5612	133	15	followed	follow	VERB
dpc-5612	133	16	by	by	ADP
dpc-5612	133	17	epistaxis	epistaxis	ADJ
dpc-5612	133	18	,	,	PUNCT
dpc-5612	133	19	and	and	CCONJ
dpc-5612	133	20	facial	facial	ADJ
dpc-5612	133	21	dermatitis	dermatitis	NOUN
dpc-5612	133	22	,	,	PUNCT
dpc-5612	133	23	reported	report	VERB
dpc-5612	133	24	136	136	NUM
dpc-5612	133	25	and	and	CCONJ
dpc-5612	133	26	104	104	NUM
dpc-5612	133	27	times	time	NOUN
dpc-5612	133	28	,	,	PUNCT
dpc-5612	133	29	respectively	respectively	ADV
dpc-5612	133	30	.	.	PUNCT
dpc-5612	134	1	other	other	ADJ
dpc-5612	134	2	notable	notable	ADJ
dpc-5612	134	3	side	side	NOUN
dpc-5612	134	4	effects	effect	NOUN
dpc-5612	134	5	included	include	VERB
dpc-5612	134	6	fatigue	fatigue	NOUN
dpc-5612	134	7	(	(	PUNCT
dpc-5612	134	8	76	76	NUM
dpc-5612	134	9	records	record	NOUN
dpc-5612	134	10	)	)	PUNCT
dpc-5612	134	11	,	,	PUNCT
dpc-5612	134	12	arthralgia	arthralgia	NOUN
dpc-5612	134	13	and	and	CCONJ
dpc-5612	134	14	myalgia	myalgia	PROPN
dpc-5612	134	15	(	(	PUNCT
dpc-5612	134	16	54	54	NUM
dpc-5612	134	17	)	)	PUNCT
dpc-5612	134	18	,	,	PUNCT
dpc-5612	134	19	conjunctivitis	conjunctivitis	NOUN
dpc-5612	134	20	(	(	PUNCT
dpc-5612	134	21	45	45	NUM
dpc-5612	134	22	)	)	PUNCT
dpc-5612	134	23	,	,	PUNCT
dpc-5612	134	24	headache	headache	NOUN
dpc-5612	134	25	(	(	PUNCT
dpc-5612	134	26	41	41	NUM
dpc-5612	134	27	)	)	PUNCT
dpc-5612	134	28	,	,	PUNCT
dpc-5612	134	29	and	and	CCONJ
dpc-5612	134	30	mood	mood	NOUN
dpc-5612	134	31	disturbances	disturbance	NOUN
dpc-5612	134	32	(	(	PUNCT
dpc-5612	134	33	27	27	NUM
dpc-5612	134	34	)	)	PUNCT
dpc-5612	134	35	.	.	PUNCT
dpc-5612	135	1	less	less	ADV
dpc-5612	135	2	common	common	ADJ
dpc-5612	135	3	adverse	adverse	ADJ
dpc-5612	135	4	events	event	NOUN
dpc-5612	135	5	included	include	VERB
dpc-5612	135	6	xerophthalmia	xerophthalmia	NOUN
dpc-5612	135	7	(	(	PUNCT
dpc-5612	135	8	7	7	NUM
dpc-5612	135	9	)	)	PUNCT
dpc-5612	135	10	,	,	PUNCT
dpc-5612	135	11	increase	increase	VERB
dpc-5612	135	12	in	in	ADP
dpc-5612	135	13	creatine	creatine	NOUN
dpc-5612	135	14	phosphokinase	phosphokinase	NOUN
dpc-5612	135	15	(	(	PUNCT
dpc-5612	135	16	2	2	NUM
dpc-5612	135	17	)	)	PUNCT
dpc-5612	135	18	,	,	PUNCT
dpc-5612	135	19	elevated	elevate	VERB
dpc-5612	135	20	liver	liver	NOUN
dpc-5612	135	21	enzyme	enzyme	NOUN
dpc-5612	135	22	levels	level	NOUN
dpc-5612	135	23	(	(	PUNCT
dpc-5612	135	24	1	1	NUM
dpc-5612	135	25	)	)	PUNCT
dpc-5612	135	26	,	,	PUNCT
dpc-5612	135	27	and	and	CCONJ
dpc-5612	135	28	muscle	muscle	NOUN
dpc-5612	135	29	cramps	cramp	NOUN
dpc-5612	135	30	(	(	PUNCT
dpc-5612	135	31	1	1	NUM
dpc-5612	135	32	)	)	PUNCT
dpc-5612	135	33	.	.	PUNCT
dpc-5612	136	1	treatment	treatment	NOUN
dpc-5612	136	2	discontinuation	discontinuation	NOUN
dpc-5612	136	3	rates	rate	NOUN
dpc-5612	136	4	remained	remain	VERB
dpc-5612	136	5	consistent	consistent	ADJ
dpc-5612	136	6	across	across	ADP
dpc-5612	136	7	the	the	DET
dpc-5612	136	8	two	two	NUM
dpc-5612	136	9	periods	period	NOUN
dpc-5612	136	10	,	,	PUNCT
dpc-5612	136	11	with	with	ADP
dpc-5612	136	12	1.1	1.1	NUM
dpc-5612	136	13	%	%	NOUN
dpc-5612	136	14	of	of	ADP
dpc-5612	136	15	patients	patient	NOUN
dpc-5612	136	16	discontinuing	discontinue	VERB
dpc-5612	136	17	oral	oral	ADJ
dpc-5612	136	18	isotretinoin	isotretinoin	PROPN
dpc-5612	136	19	during	during	ADP
dpc-5612	136	20	the	the	DET
dpc-5612	136	21	non	non	ADJ
dpc-5612	136	22	-	-	ADJ
dpc-5612	136	23	sunny	sunny	ADJ
dpc-5612	136	24	months	month	NOUN
dpc-5612	136	25	and	and	CCONJ
dpc-5612	136	26	1.2	1.2	NUM
dpc-5612	136	27	%	%	NOUN
dpc-5612	136	28	during	during	ADP
dpc-5612	136	29	the	the	DET
dpc-5612	136	30	sunny	sunny	ADJ
dpc-5612	136	31	months	month	NOUN
dpc-5612	136	32	(	(	PUNCT
dpc-5612	136	33	p=0.999	p=0.999	NOUN
dpc-5612	136	34	)	)	PUNCT
dpc-5612	136	35	.	.	PUNCT
dpc-5612	137	1	it	it	PRON
dpc-5612	137	2	is	be	AUX
dpc-5612	137	3	worth	worth	ADJ
dpc-5612	137	4	noting	note	VERB
dpc-5612	137	5	that	that	SCONJ
dpc-5612	137	6	the	the	DET
dpc-5612	137	7	treatment	treatment	NOUN
dpc-5612	137	8	was	be	AUX
dpc-5612	137	9	not	not	PART
dpc-5612	137	10	discontinued	discontinue	VERB
dpc-5612	137	11	due	due	ADJ
dpc-5612	137	12	to	to	ADP
dpc-5612	137	13	adverse	adverse	ADJ
dpc-5612	137	14	effects	effect	NOUN
dpc-5612	137	15	related	relate	VERB
dpc-5612	137	16	to	to	ADP
dpc-5612	137	17	the	the	DET
dpc-5612	137	18	medication	medication	NOUN
dpc-5612	137	19	but	but	CCONJ
dpc-5612	137	20	rather	rather	ADV
dpc-5612	137	21	due	due	ADP
dpc-5612	137	22	to	to	ADP
dpc-5612	137	23	a	a	DET
dpc-5612	137	24	temporary	temporary	ADJ
dpc-5612	137	25	suspension	suspension	NOUN
dpc-5612	137	26	for	for	ADP
dpc-5612	137	27	personal	personal	ADJ
dpc-5612	137	28	reasons	reason	NOUN
dpc-5612	137	29	and	and	CCONJ
dpc-5612	137	30	surgical	surgical	ADJ
dpc-5612	137	31	procedures	procedure	NOUN
dpc-5612	137	32	.	.	PUNCT
dpc-5612	138	1	relationship	relationship	NOUN
dpc-5612	138	2	between	between	ADP
dpc-5612	138	3	daily	daily	ADJ
dpc-5612	138	4	dose	dose	NOUN
dpc-5612	138	5	and	and	CCONJ
dpc-5612	138	6	treatment	treatment	NOUN
dpc-5612	138	7	effectiveness	effectiveness	NOUN
dpc-5612	138	8	a	a	DET
dpc-5612	138	9	further	further	ADJ
dpc-5612	138	10	study	study	NOUN
dpc-5612	138	11	objective	objective	NOUN
dpc-5612	138	12	was	be	AUX
dpc-5612	138	13	to	to	PART
dpc-5612	138	14	assess	assess	VERB
dpc-5612	138	15	the	the	DET
dpc-5612	138	16	therapeutic	therapeutic	ADJ
dpc-5612	138	17	response	response	NOUN
dpc-5612	138	18	based	base	VERB
dpc-5612	138	19	on	on	ADP
dpc-5612	138	20	the	the	DET
dpc-5612	138	21	daily	daily	ADJ
dpc-5612	138	22	dosage	dosage	NOUN
dpc-5612	138	23	of	of	ADP
dpc-5612	138	24	oral	oral	ADJ
dpc-5612	138	25	isotretinoin	isotretinoin	NOUN
dpc-5612	138	26	across	across	ADP
dpc-5612	138	27	the	the	DET
dpc-5612	138	28	three	three	NUM
dpc-5612	138	29	different	different	ADJ
dpc-5612	138	30	skin	skin	NOUN
dpc-5612	138	31	sites	site	NOUN
dpc-5612	138	32	.	.	PUNCT
dpc-5612	139	1	the	the	DET
dpc-5612	139	2	relationship	relationship	NOUN
dpc-5612	139	3	between	between	ADP
dpc-5612	139	4	the	the	DET
dpc-5612	139	5	differential	differential	ADJ
dpc-5612	139	6	daily	daily	PROPN
dpc-5612	139	7	dose	dose	NOUN
dpc-5612	139	8	and	and	CCONJ
dpc-5612	139	9	the	the	DET
dpc-5612	139	10	differential	differential	ADJ
dpc-5612	139	11	leeds	leed	NOUN
dpc-5612	139	12	scores	score	NOUN
dpc-5612	139	13	,	,	PUNCT
dpc-5612	139	14	for	for	ADP
dpc-5612	139	15	each	each	DET
dpc-5612	139	16	site	site	NOUN
dpc-5612	139	17	,	,	PUNCT
dpc-5612	139	18	showed	show	VERB
dpc-5612	139	19	no	no	DET
dpc-5612	139	20	significant	significant	ADJ
dpc-5612	139	21	association	association	NOUN
dpc-5612	139	22	(	(	PUNCT
dpc-5612	139	23	figure	figure	NOUN
dpc-5612	139	24	1	1	NUM
dpc-5612	139	25	)	)	PUNCT
dpc-5612	139	26	.	.	PUNCT
dpc-5612	140	1	original	original	ADJ
dpc-5612	140	2	article	article	NOUN
dpc-5612	140	3	|	|	ADV
dpc-5612	140	4	dermatol	dermatol	ADJ
dpc-5612	140	5	pract	pract	NOUN
dpc-5612	140	6	concept	concept	NOUN
dpc-5612	140	7	.	.	PUNCT
dpc-5612	141	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	141	2	5	5	NUM
dpc-5612	141	3	table	table	NOUN
dpc-5612	141	4	2	2	NUM
dpc-5612	141	5	.	.	PUNCT
dpc-5612	141	6	acne	acne	NOUN
dpc-5612	141	7	severity	severity	NOUN
dpc-5612	141	8	scores	score	NOUN
dpc-5612	141	9	by	by	ADP
dpc-5612	141	10	area	area	NOUN
dpc-5612	141	11	,	,	PUNCT
dpc-5612	141	12	comparing	compare	VERB
dpc-5612	141	13	before	before	ADP
dpc-5612	141	14	and	and	CCONJ
dpc-5612	141	15	after	after	ADP
dpc-5612	141	16	treatment	treatment	NOUN
dpc-5612	141	17	.	.	PUNCT
dpc-5612	142	1	after	after	SCONJ
dpc-5612	142	2	treatment	treatment	NOUN
dpc-5612	142	3	data	datum	NOUN
dpc-5612	142	4	have	have	AUX
dpc-5612	142	5	been	be	AUX
dpc-5612	142	6	computed	compute	VERB
dpc-5612	142	7	as	as	ADP
dpc-5612	142	8	the	the	DET
dpc-5612	142	9	median	median	NOUN
dpc-5612	142	10	of	of	ADP
dpc-5612	142	11	the	the	DET
dpc-5612	142	12	last	last	ADJ
dpc-5612	142	13	available	available	ADJ
dpc-5612	142	14	data	datum	NOUN
dpc-5612	142	15	for	for	ADP
dpc-5612	142	16	each	each	DET
dpc-5612	142	17	patient	patient	NOUN
dpc-5612	142	18	,	,	PUNCT
dpc-5612	142	19	in	in	ADP
dpc-5612	142	20	each	each	DET
dpc-5612	142	21	area	area	NOUN
dpc-5612	142	22	of	of	ADP
dpc-5612	142	23	interest	interest	NOUN
dpc-5612	142	24	.	.	PUNCT
dpc-5612	143	1	n	n	CCONJ
dpc-5612	143	2	before	before	ADP
dpc-5612	143	3	treatment	treatment	NOUN
dpc-5612	143	4	after	after	ADP
dpc-5612	143	5	treatment	treatment	NOUN
dpc-5612	143	6	p	p	NOUN
dpc-5612	143	7	-	-	PUNCT
dpc-5612	143	8	value	value	NOUN
dpc-5612	143	9	face	face	NOUN
dpc-5612	143	10	leeds	leed	NOUN
dpc-5612	143	11	revised	revise	VERB
dpc-5612	143	12	acne	acne	NOUN
dpc-5612	143	13	grading	grade	VERB
dpc-5612	143	14	system	system	NOUN
dpc-5612	143	15	,	,	PUNCT
dpc-5612	144	1	median	median	PROPN
dpc-5612	145	1	[	[	X
dpc-5612	145	2	q1	q1	NOUN
dpc-5612	145	3	q3	q3	NOUN
dpc-5612	145	4	]	]	X
dpc-5612	145	5	352	352	NUM
dpc-5612	145	6	3	3	NUM
dpc-5612	146	1	[	[	X
dpc-5612	146	2	2;4	2;4	NUM
dpc-5612	146	3	]	]	X
dpc-5612	146	4	0	0	PUNCT
dpc-5612	147	1	[	[	X
dpc-5612	147	2	0;1	0;1	X
dpc-5612	147	3	]	]	X
dpc-5612	147	4	<	<	X
dpc-5612	147	5	0.001	0.001	NUM
dpc-5612	147	6	back	back	NOUN
dpc-5612	147	7	leeds	leed	NOUN
dpc-5612	147	8	revised	revise	VERB
dpc-5612	147	9	acne	acne	NOUN
dpc-5612	147	10	grading	grade	VERB
dpc-5612	147	11	system	system	NOUN
dpc-5612	147	12	,	,	PUNCT
dpc-5612	147	13	median	median	PROPN
dpc-5612	147	14	[	[	X
dpc-5612	147	15	q1	q1	NOUN
dpc-5612	147	16	q3	q3	NOUN
dpc-5612	147	17	]	]	X
dpc-5612	147	18	219	219	NUM
dpc-5612	147	19	3	3	NUM
dpc-5612	148	1	[	[	X
dpc-5612	148	2	2;4	2;4	NUM
dpc-5612	148	3	]	]	X
dpc-5612	148	4	0	0	PUNCT
dpc-5612	149	1	[	[	X
dpc-5612	149	2	0;1	0;1	X
dpc-5612	149	3	]	]	PUNCT
dpc-5612	149	4	<	<	X
dpc-5612	149	5	0.001	0.001	NUM
dpc-5612	149	6	chest	chest	NOUN
dpc-5612	149	7	leeds	leed	NOUN
dpc-5612	149	8	revised	revise	VERB
dpc-5612	149	9	acne	acne	NOUN
dpc-5612	149	10	grading	grade	VERB
dpc-5612	149	11	system	system	NOUN
dpc-5612	149	12	,	,	PUNCT
dpc-5612	149	13	median	median	PROPN
dpc-5612	149	14	[	[	X
dpc-5612	149	15	q1	q1	NOUN
dpc-5612	149	16	q3	q3	NOUN
dpc-5612	149	17	]	]	X
dpc-5612	149	18	118	118	NUM
dpc-5612	149	19	2	2	NUM
dpc-5612	150	1	[	[	X
dpc-5612	150	2	1;3	1;3	NUM
dpc-5612	150	3	]	]	PUNCT
dpc-5612	150	4	0	0	PUNCT
dpc-5612	151	1	[	[	X
dpc-5612	151	2	0;1	0;1	X
dpc-5612	151	3	]	]	X
dpc-5612	151	4	<	<	X
dpc-5612	151	5	0.001	0.001	NUM
dpc-5612	151	6	[	[	X
dpc-5612	151	7	q1	q1	NOUN
dpc-5612	151	8	q3	q3	NOUN
dpc-5612	151	9	]	]	PUNCT
dpc-5612	151	10	:	:	PUNCT
dpc-5612	151	11	first	first	ADJ
dpc-5612	151	12	and	and	CCONJ
dpc-5612	151	13	third	third	ADJ
dpc-5612	151	14	quantiles	quantile	NOUN
dpc-5612	151	15	table	table	VERB
dpc-5612	151	16	3	3	NUM
dpc-5612	151	17	.	.	PUNCT
dpc-5612	151	18	comparison	comparison	NOUN
dpc-5612	151	19	of	of	ADP
dpc-5612	151	20	oral	oral	ADJ
dpc-5612	151	21	isotretinoin	isotretinoin	PROPN
dpc-5612	151	22	daily	daily	PROPN
dpc-5612	151	23	dose	dose	PROPN
dpc-5612	151	24	,	,	PUNCT
dpc-5612	151	25	discontinuation	discontinuation	NOUN
dpc-5612	151	26	,	,	PUNCT
dpc-5612	151	27	and	and	CCONJ
dpc-5612	151	28	adverse	adverse	ADJ
dpc-5612	151	29	events	event	NOUN
dpc-5612	151	30	occurrence	occurrence	NOUN
dpc-5612	151	31	in	in	ADP
dpc-5612	151	32	non	non	ADJ
dpc-5612	151	33	-	-	ADJ
dpc-5612	151	34	sunny	sunny	ADJ
dpc-5612	151	35	and	and	CCONJ
dpc-5612	151	36	sunny	sunny	ADJ
dpc-5612	151	37	months	month	NOUN
dpc-5612	151	38	.	.	PUNCT
dpc-5612	152	1	not	not	PART
dpc-5612	152	2	-	-	PUNCT
dpc-5612	152	3	sunny	sunny	ADJ
dpc-5612	152	4	period	period	NOUN
dpc-5612	152	5	refers	refer	VERB
dpc-5612	152	6	to	to	ADP
dpc-5612	152	7	months	month	NOUN
dpc-5612	152	8	from	from	ADP
dpc-5612	152	9	october	october	PROPN
dpc-5612	152	10	to	to	PART
dpc-5612	152	11	may	may	AUX
dpc-5612	152	12	while	while	SCONJ
dpc-5612	152	13	sunny	sunny	ADJ
dpc-5612	152	14	period	period	NOUN
dpc-5612	152	15	is	be	AUX
dpc-5612	152	16	between	between	ADP
dpc-5612	152	17	june	june	PROPN
dpc-5612	152	18	and	and	CCONJ
dpc-5612	152	19	september	september	PROPN
dpc-5612	152	20	.	.	PUNCT
dpc-5612	153	1	non	non	ADJ
dpc-5612	153	2	-	-	ADJ
dpc-5612	153	3	sunny	sunny	ADJ
dpc-5612	153	4	months	month	NOUN
dpc-5612	153	5	sunny	sunny	ADJ
dpc-5612	153	6	months	month	NOUN
dpc-5612	153	7	p	p	X
dpc-5612	153	8	-	-	PUNCT
dpc-5612	153	9	value	value	NOUN
dpc-5612	153	10	drug	drug	NOUN
dpc-5612	153	11	daily	daily	NOUN
dpc-5612	153	12	dose	dose	PROPN
dpc-5612	153	13	(	(	PUNCT
dpc-5612	153	14	mg	mg	PROPN
dpc-5612	153	15	)	)	PUNCT
dpc-5612	153	16	,	,	PUNCT
dpc-5612	153	17	median	median	PROPN
dpc-5612	154	1	[	[	X
dpc-5612	154	2	q1	q1	NOUN
dpc-5612	154	3	q3	q3	NOUN
dpc-5612	154	4	]	]	X
dpc-5612	154	5	15.0	15.0	NUM
dpc-5612	154	6	[	[	PUNCT
dpc-5612	154	7	10.0	10.0	NUM
dpc-5612	154	8	20.0	20.0	NUM
dpc-5612	154	9	]	]	PUNCT
dpc-5612	154	10	10.0	10.0	NUM
dpc-5612	155	1	[	[	X
dpc-5612	155	2	10.0	10.0	NUM
dpc-5612	155	3	15.0	15.0	NUM
dpc-5612	155	4	]	]	PUNCT
dpc-5612	156	1	<	<	X
dpc-5612	156	2	0.001	0.001	NUM
dpc-5612	156	3	adverse	adverse	ADJ
dpc-5612	156	4	events	event	NOUN
dpc-5612	156	5	,	,	PUNCT
dpc-5612	156	6	n	n	CCONJ
dpc-5612	156	7	(	(	PUNCT
dpc-5612	156	8	%	%	INTJ
dpc-5612	156	9	)	)	PUNCT
dpc-5612	157	1	<	<	X
dpc-5612	157	2	0.001	0.001	NUM
dpc-5612	157	3	none	none	NOUN
dpc-5612	157	4	2,224	2,224	NUM
dpc-5612	157	5	(	(	PUNCT
dpc-5612	157	6	60.8	60.8	NUM
dpc-5612	157	7	%	%	NOUN
dpc-5612	157	8	)	)	PUNCT
dpc-5612	157	9	294	294	NUM
dpc-5612	157	10	(	(	PUNCT
dpc-5612	157	11	71.7	71.7	NUM
dpc-5612	157	12	%	%	NOUN
dpc-5612	157	13	)	)	PUNCT
dpc-5612	157	14	1	1	NUM
dpc-5612	157	15	or	or	CCONJ
dpc-5612	157	16	more	more	ADJ
dpc-5612	157	17	1,434	1,434	NUM
dpc-5612	157	18	(	(	PUNCT
dpc-5612	157	19	39.2	39.2	NUM
dpc-5612	157	20	%	%	NOUN
dpc-5612	157	21	)	)	PUNCT
dpc-5612	157	22	116	116	NUM
dpc-5612	157	23	(	(	PUNCT
dpc-5612	157	24	28.3	28.3	NUM
dpc-5612	157	25	%	%	NOUN
dpc-5612	157	26	)	)	PUNCT
dpc-5612	157	27	drug	drug	NOUN
dpc-5612	157	28	discontinuation	discontinuation	NOUN
dpc-5612	157	29	,	,	PUNCT
dpc-5612	157	30	n	n	PROPN
dpc-5612	157	31	(	(	PUNCT
dpc-5612	157	32	%	%	INTJ
dpc-5612	157	33	)	)	PUNCT
dpc-5612	157	34	0.999	0.999	NUM
dpc-5612	157	35	yes	yes	NUM
dpc-5612	157	36	29	29	NUM
dpc-5612	157	37	(	(	PUNCT
dpc-5612	157	38	1.1	1.1	NUM
dpc-5612	157	39	%	%	NOUN
dpc-5612	157	40	)	)	PUNCT
dpc-5612	157	41	18	18	NUM
dpc-5612	157	42	(	(	PUNCT
dpc-5612	157	43	1.2	1.2	NUM
dpc-5612	157	44	%	%	NOUN
dpc-5612	157	45	)	)	PUNCT
dpc-5612	158	1	no	no	DET
dpc-5612	158	2	2,488	2,488	NUM
dpc-5612	158	3	(	(	PUNCT
dpc-5612	158	4	98.9	98.9	NUM
dpc-5612	158	5	%	%	NOUN
dpc-5612	158	6	)	)	PUNCT
dpc-5612	158	7	1,537	1,537	NUM
dpc-5612	158	8	(	(	PUNCT
dpc-5612	158	9	98.8	98.8	NUM
dpc-5612	158	10	%	%	NOUN
dpc-5612	158	11	)	)	PUNCT
dpc-5612	159	1	[	[	X
dpc-5612	159	2	q1	q1	NOUN
dpc-5612	159	3	q3	q3	NOUN
dpc-5612	159	4	]	]	PUNCT
dpc-5612	159	5	:	:	PUNCT
dpc-5612	159	6	first	first	ADJ
dpc-5612	159	7	and	and	CCONJ
dpc-5612	159	8	third	third	ADJ
dpc-5612	159	9	quantiles	quantile	NOUN
dpc-5612	159	10	figure	figure	VERB
dpc-5612	159	11	1	1	NUM
dpc-5612	159	12	.	.	PUNCT
dpc-5612	159	13	scatter	scatter	NOUN
dpc-5612	159	14	plot	plot	NOUN
dpc-5612	159	15	comparing	compare	VERB
dpc-5612	159	16	differential	differential	ADJ
dpc-5612	159	17	values	value	NOUN
dpc-5612	159	18	in	in	ADP
dpc-5612	159	19	dose	dose	NOUN
dpc-5612	159	20	between	between	ADP
dpc-5612	159	21	first	first	ADV
dpc-5612	159	22	versus	versus	ADP
dpc-5612	159	23	last	last	ADJ
dpc-5612	159	24	month	month	NOUN
dpc-5612	159	25	’s	’s	PART
dpc-5612	159	26	daily	daily	ADJ
dpc-5612	159	27	dosage	dosage	NOUN
dpc-5612	159	28	and	and	CCONJ
dpc-5612	159	29	preversus	preversus	ADJ
dpc-5612	159	30	post	post	ADJ
dpc-5612	159	31	-	-	ADJ
dpc-5612	159	32	treatment	treatment	ADJ
dpc-5612	159	33	leeds	leed	NOUN
dpc-5612	159	34	severity	severity	NOUN
dpc-5612	159	35	scoring	scoring	NOUN
dpc-5612	159	36	system	system	NOUN
dpc-5612	159	37	by	by	ADP
dpc-5612	159	38	skin	skin	NOUN
dpc-5612	159	39	site	site	NOUN
dpc-5612	159	40	.	.	PUNCT
dpc-5612	160	1	conclusions	conclusion	NOUN
dpc-5612	160	2	the	the	DET
dpc-5612	160	3	primary	primary	ADJ
dpc-5612	160	4	objective	objective	NOUN
dpc-5612	160	5	of	of	ADP
dpc-5612	160	6	this	this	DET
dpc-5612	160	7	study	study	NOUN
dpc-5612	160	8	was	be	AUX
dpc-5612	160	9	to	to	PART
dpc-5612	160	10	assess	assess	VERB
dpc-5612	160	11	the	the	DET
dpc-5612	160	12	safety	safety	NOUN
dpc-5612	160	13	of	of	ADP
dpc-5612	160	14	administering	administer	VERB
dpc-5612	160	15	oral	oral	ADJ
dpc-5612	160	16	isotretinoin	isotretinoin	NOUN
dpc-5612	160	17	during	during	ADP
dpc-5612	160	18	sunny	sunny	ADJ
dpc-5612	160	19	seasons	season	NOUN
dpc-5612	160	20	.	.	PUNCT
dpc-5612	161	1	the	the	DET
dpc-5612	161	2	extensive	extensive	ADJ
dpc-5612	161	3	time	time	NOUN
dpc-5612	161	4	frame	frame	NOUN
dpc-5612	161	5	analyzed	analyze	VERB
dpc-5612	161	6	retrospectively	retrospectively	ADV
dpc-5612	161	7	,	,	PUNCT
dpc-5612	161	8	along	along	ADP
dpc-5612	161	9	with	with	ADP
dpc-5612	161	10	the	the	DET
dpc-5612	161	11	high	high	ADJ
dpc-5612	161	12	and	and	CCONJ
dpc-5612	161	13	steady	steady	ADJ
dpc-5612	161	14	patient	patient	ADJ
dpc-5612	161	15	attendance	attendance	NOUN
dpc-5612	161	16	at	at	ADP
dpc-5612	161	17	our	our	PRON
dpc-5612	161	18	acne	acne	NOUN
dpc-5612	161	19	clinic	clinic	NOUN
dpc-5612	161	20	,	,	PUNCT
dpc-5612	161	21	allowed	allow	VERB
dpc-5612	161	22	for	for	ADP
dpc-5612	161	23	the	the	DET
dpc-5612	161	24	inclusion	inclusion	NOUN
dpc-5612	161	25	of	of	ADP
dpc-5612	161	26	a	a	DET
dpc-5612	161	27	greater	great	ADJ
dpc-5612	161	28	number	number	NOUN
dpc-5612	161	29	of	of	ADP
dpc-5612	161	30	patients	patient	NOUN
dpc-5612	161	31	than	than	SCONJ
dpc-5612	161	32	initially	initially	ADV
dpc-5612	161	33	estimated	estimate	VERB
dpc-5612	161	34	through	through	ADP
dpc-5612	161	35	the	the	DET
dpc-5612	161	36	sample	sample	NOUN
dpc-5612	161	37	size	size	NOUN
dpc-5612	161	38	calculation	calculation	NOUN
dpc-5612	161	39	.	.	PUNCT
dpc-5612	162	1	the	the	DET
dpc-5612	162	2	sample	sample	NOUN
dpc-5612	162	3	included	include	VERB
dpc-5612	162	4	provided	provide	VERB
dpc-5612	162	5	a	a	DET
dpc-5612	162	6	robust	robust	ADJ
dpc-5612	162	7	opportunity	opportunity	NOUN
dpc-5612	162	8	to	to	PART
dpc-5612	162	9	offer	offer	VERB
dpc-5612	162	10	evidence	evidence	NOUN
dpc-5612	162	11	regarding	regard	VERB
dpc-5612	162	12	the	the	DET
dpc-5612	162	13	common	common	ADJ
dpc-5612	162	14	belief	belief	NOUN
dpc-5612	162	15	that	that	SCONJ
dpc-5612	162	16	oral	oral	ADJ
dpc-5612	162	17	isotretinoin	isotretinoin	NOUN
dpc-5612	162	18	should	should	AUX
dpc-5612	162	19	be	be	AUX
dpc-5612	162	20	contraindicated	contraindicate	VERB
dpc-5612	162	21	during	during	ADP
dpc-5612	162	22	sunny	sunny	ADJ
dpc-5612	162	23	months	month	NOUN
dpc-5612	162	24	,	,	PUNCT
dpc-5612	162	25	either	either	CCONJ
dpc-5612	162	26	confirming	confirm	VERB
dpc-5612	162	27	or	or	CCONJ
dpc-5612	162	28	refuting	refute	VERB
dpc-5612	162	29	this	this	DET
dpc-5612	162	30	assumption	assumption	NOUN
dpc-5612	162	31	.	.	PUNCT
dpc-5612	163	1	the	the	DET
dpc-5612	163	2	patients	patient	NOUN
dpc-5612	163	3	enrolled	enrol	VERB
dpc-5612	163	4	represent	represent	VERB
dpc-5612	163	5	a	a	DET
dpc-5612	163	6	typical	typical	ADJ
dpc-5612	163	7	acne	acne	NOUN
dpc-5612	163	8	patient	patient	NOUN
dpc-5612	163	9	cohort	cohort	NOUN
dpc-5612	163	10	receiving	receive	VERB
dpc-5612	163	11	oral	oral	ADJ
dpc-5612	163	12	isotretinoin	isotretinoin	NOUN
dpc-5612	163	13	,	,	PUNCT
dpc-5612	163	14	both	both	PRON
dpc-5612	163	15	demographically	demographically	ADV
dpc-5612	163	16	and	and	CCONJ
dpc-5612	163	17	clinically	clinically	ADV
dpc-5612	163	18	.	.	PUNCT
dpc-5612	164	1	truncal	truncal	ADJ
dpc-5612	164	2	acne	acne	NOUN
dpc-5612	164	3	was	be	AUX
dpc-5612	164	4	significantly	significantly	ADV
dpc-5612	164	5	more	more	ADV
dpc-5612	164	6	prevalent	prevalent	ADJ
dpc-5612	164	7	in	in	ADP
dpc-5612	164	8	male	male	ADJ
dpc-5612	164	9	patients	patient	NOUN
dpc-5612	164	10	than	than	ADP
dpc-5612	164	11	in	in	ADP
dpc-5612	164	12	females	female	NOUN
dpc-5612	164	13	(	(	PUNCT
dpc-5612	164	14	table	table	NOUN
dpc-5612	164	15	1	1	NUM
dpc-5612	164	16	)	)	PUNCT
dpc-5612	164	17	,	,	PUNCT
dpc-5612	164	18	in	in	ADP
dpc-5612	164	19	accordance	accordance	NOUN
dpc-5612	164	20	with	with	ADP
dpc-5612	164	21	existing	exist	VERB
dpc-5612	164	22	epidemiological	epidemiological	ADJ
dpc-5612	164	23	data	datum	NOUN
dpc-5612	164	24	[	[	X
dpc-5612	164	25	16	16	NUM
dpc-5612	164	26	]	]	PUNCT
dpc-5612	164	27	.	.	PUNCT
dpc-5612	165	1	6	6	NUM
dpc-5612	165	2	original	original	ADJ
dpc-5612	165	3	article	article	NOUN
dpc-5612	165	4	|	|	ADV
dpc-5612	165	5	dermatol	dermatol	ADJ
dpc-5612	165	6	pract	pract	NOUN
dpc-5612	165	7	concept	concept	NOUN
dpc-5612	165	8	.	.	PUNCT
dpc-5612	166	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	166	2	the	the	DET
dpc-5612	166	3	systematic	systematic	ADJ
dpc-5612	166	4	reduction	reduction	NOUN
dpc-5612	166	5	in	in	ADP
dpc-5612	166	6	the	the	DET
dpc-5612	166	7	daily	daily	ADJ
dpc-5612	166	8	dosage	dosage	NOUN
dpc-5612	166	9	of	of	ADP
dpc-5612	166	10	oral	oral	ADJ
dpc-5612	166	11	isotretinoin	isotretinoin	NOUN
dpc-5612	166	12	before	before	ADP
dpc-5612	166	13	the	the	DET
dpc-5612	166	14	start	start	NOUN
dpc-5612	166	15	of	of	ADP
dpc-5612	166	16	the	the	DET
dpc-5612	166	17	sunny	sunny	ADJ
dpc-5612	166	18	season	season	NOUN
dpc-5612	166	19	raises	raise	VERB
dpc-5612	166	20	the	the	DET
dpc-5612	166	21	question	question	NOUN
dpc-5612	166	22	of	of	ADP
dpc-5612	166	23	whether	whether	SCONJ
dpc-5612	166	24	this	this	DET
dpc-5612	166	25	practice	practice	NOUN
dpc-5612	166	26	affects	affect	VERB
dpc-5612	166	27	the	the	DET
dpc-5612	166	28	treatment	treatment	NOUN
dpc-5612	166	29	’s	’s	PART
dpc-5612	166	30	effectiveness	effectiveness	NOUN
dpc-5612	166	31	.	.	PUNCT
dpc-5612	167	1	figure	figure	NOUN
dpc-5612	167	2	1	1	NUM
dpc-5612	167	3	shows	show	VERB
dpc-5612	167	4	the	the	DET
dpc-5612	167	5	relationship	relationship	NOUN
dpc-5612	167	6	between	between	ADP
dpc-5612	167	7	mean	mean	ADJ
dpc-5612	167	8	daily	daily	ADJ
dpc-5612	167	9	dosages	dosage	NOUN
dpc-5612	167	10	(	(	PUNCT
dpc-5612	167	11	from	from	ADP
dpc-5612	167	12	the	the	DET
dpc-5612	167	13	start	start	NOUN
dpc-5612	167	14	to	to	ADP
dpc-5612	167	15	the	the	DET
dpc-5612	167	16	completion	completion	NOUN
dpc-5612	167	17	of	of	ADP
dpc-5612	167	18	treatment	treatment	NOUN
dpc-5612	167	19	)	)	PUNCT
dpc-5612	167	20	and	and	CCONJ
dpc-5612	167	21	changes	change	NOUN
dpc-5612	167	22	in	in	ADP
dpc-5612	167	23	acne	acne	NOUN
dpc-5612	167	24	severity	severity	NOUN
dpc-5612	167	25	.	.	PUNCT
dpc-5612	168	1	for	for	ADP
dpc-5612	168	2	the	the	DET
dpc-5612	168	3	back	back	NOUN
dpc-5612	168	4	site	site	NOUN
dpc-5612	168	5	,	,	PUNCT
dpc-5612	168	6	a	a	DET
dpc-5612	168	7	positive	positive	ADJ
dpc-5612	168	8	trend	trend	NOUN
dpc-5612	168	9	was	be	AUX
dpc-5612	168	10	found	find	VERB
dpc-5612	168	11	,	,	PUNCT
dpc-5612	168	12	albeit	albeit	SCONJ
dpc-5612	168	13	not	not	PART
dpc-5612	168	14	significant	significant	ADJ
dpc-5612	168	15	(	(	PUNCT
dpc-5612	168	16	p=0.085	p=0.085	NOUN
dpc-5612	168	17	)	)	PUNCT
dpc-5612	168	18	.	.	PUNCT
dpc-5612	169	1	clinically	clinically	ADV
dpc-5612	169	2	,	,	PUNCT
dpc-5612	169	3	this	this	PRON
dpc-5612	169	4	suggests	suggest	VERB
dpc-5612	169	5	that	that	SCONJ
dpc-5612	169	6	a	a	DET
dpc-5612	169	7	temporary	temporary	ADJ
dpc-5612	169	8	reduction	reduction	NOUN
dpc-5612	169	9	in	in	ADP
dpc-5612	169	10	daily	daily	ADJ
dpc-5612	169	11	dosage	dosage	NOUN
dpc-5612	169	12	does	do	AUX
dpc-5612	169	13	not	not	PART
dpc-5612	169	14	significantly	significantly	ADV
dpc-5612	169	15	impact	impact	VERB
dpc-5612	169	16	the	the	DET
dpc-5612	169	17	therapeutic	therapeutic	ADJ
dpc-5612	169	18	efficacy	efficacy	NOUN
dpc-5612	169	19	of	of	ADP
dpc-5612	169	20	oral	oral	ADJ
dpc-5612	169	21	isotretinoin	isotretinoin	PROPN
dpc-5612	170	1	[	[	X
dpc-5612	170	2	23	23	NUM
dpc-5612	170	3	]	]	PUNCT
dpc-5612	170	4	.	.	PUNCT
dpc-5612	171	1	the	the	DET
dpc-5612	171	2	study	study	NOUN
dpc-5612	171	3	results	result	NOUN
dpc-5612	171	4	have	have	VERB
dpc-5612	171	5	several	several	ADJ
dpc-5612	171	6	limitations	limitation	NOUN
dpc-5612	171	7	.	.	PUNCT
dpc-5612	172	1	as	as	ADP
dpc-5612	172	2	a	a	DET
dpc-5612	172	3	retrospective	retrospective	ADJ
dpc-5612	172	4	study	study	NOUN
dpc-5612	172	5	,	,	PUNCT
dpc-5612	172	6	it	it	PRON
dpc-5612	172	7	did	do	AUX
dpc-5612	172	8	not	not	PART
dpc-5612	172	9	allow	allow	VERB
dpc-5612	172	10	for	for	ADP
dpc-5612	172	11	the	the	DET
dpc-5612	172	12	collection	collection	NOUN
dpc-5612	172	13	of	of	ADP
dpc-5612	172	14	detailed	detailed	ADJ
dpc-5612	172	15	information	information	NOUN
dpc-5612	172	16	on	on	ADP
dpc-5612	172	17	patients	patient	NOUN
dpc-5612	172	18	'	'	PART
dpc-5612	172	19	sun	sun	NOUN
dpc-5612	172	20	exposure	exposure	NOUN
dpc-5612	172	21	habits	habit	NOUN
dpc-5612	172	22	,	,	PUNCT
dpc-5612	172	23	including	include	VERB
dpc-5612	172	24	the	the	DET
dpc-5612	172	25	use	use	NOUN
dpc-5612	172	26	of	of	ADP
dpc-5612	172	27	photoprotection	photoprotection	NOUN
dpc-5612	172	28	.	.	PUNCT
dpc-5612	173	1	given	give	VERB
dpc-5612	173	2	the	the	DET
dpc-5612	173	3	young	young	ADJ
dpc-5612	173	4	age	age	NOUN
dpc-5612	173	5	of	of	ADP
dpc-5612	173	6	the	the	DET
dpc-5612	173	7	participants	participant	NOUN
dpc-5612	173	8	,	,	PUNCT
dpc-5612	173	9	it	it	PRON
dpc-5612	173	10	is	be	AUX
dpc-5612	173	11	likely	likely	ADJ
dpc-5612	173	12	that	that	SCONJ
dpc-5612	173	13	their	their	PRON
dpc-5612	173	14	ultraviolet	ultraviolet	ADJ
dpc-5612	173	15	exposure	exposure	NOUN
dpc-5612	173	16	was	be	AUX
dpc-5612	173	17	primarily	primarily	ADV
dpc-5612	173	18	recreational	recreational	ADJ
dpc-5612	173	19	rather	rather	ADV
dpc-5612	173	20	than	than	ADP
dpc-5612	173	21	occupational	occupational	ADJ
dpc-5612	173	22	,	,	PUNCT
dpc-5612	173	23	but	but	CCONJ
dpc-5612	173	24	specific	specific	ADJ
dpc-5612	173	25	data	datum	NOUN
dpc-5612	173	26	on	on	ADP
dpc-5612	173	27	this	this	PRON
dpc-5612	173	28	were	be	AUX
dpc-5612	173	29	not	not	PART
dpc-5612	173	30	available	available	ADJ
dpc-5612	173	31	.	.	PUNCT
dpc-5612	174	1	additionally	additionally	ADV
dpc-5612	174	2	,	,	PUNCT
dpc-5612	174	3	while	while	SCONJ
dpc-5612	174	4	comparing	compare	VERB
dpc-5612	174	5	the	the	DET
dpc-5612	174	6	four	four	NUM
dpc-5612	174	7	months	month	NOUN
dpc-5612	174	8	with	with	ADP
dpc-5612	174	9	the	the	DET
dpc-5612	174	10	highest	high	ADJ
dpc-5612	174	11	uv	uv	NOUN
dpc-5612	174	12	radiation	radiation	NOUN
dpc-5612	174	13	to	to	ADP
dpc-5612	174	14	the	the	DET
dpc-5612	174	15	remaining	remain	VERB
dpc-5612	174	16	eight	eight	NUM
dpc-5612	174	17	months	month	NOUN
dpc-5612	174	18	was	be	AUX
dpc-5612	174	19	a	a	DET
dpc-5612	174	20	rational	rational	ADJ
dpc-5612	174	21	approach	approach	NOUN
dpc-5612	174	22	,	,	PUNCT
dpc-5612	174	23	it	it	PRON
dpc-5612	174	24	was	be	AUX
dpc-5612	174	25	somewhat	somewhat	ADV
dpc-5612	174	26	arbitrary	arbitrary	ADJ
dpc-5612	174	27	.	.	PUNCT
dpc-5612	175	1	the	the	DET
dpc-5612	175	2	findings	finding	NOUN
dpc-5612	175	3	of	of	ADP
dpc-5612	175	4	this	this	DET
dpc-5612	175	5	study	study	NOUN
dpc-5612	175	6	are	be	AUX
dpc-5612	175	7	specific	specific	ADJ
dpc-5612	175	8	to	to	ADP
dpc-5612	175	9	the	the	DET
dpc-5612	175	10	geographical	geographical	ADJ
dpc-5612	175	11	area	area	NOUN
dpc-5612	175	12	in	in	ADP
dpc-5612	175	13	which	which	PRON
dpc-5612	175	14	it	it	PRON
dpc-5612	175	15	was	be	AUX
dpc-5612	175	16	conducted	conduct	VERB
dpc-5612	175	17	and	and	CCONJ
dpc-5612	175	18	may	may	AUX
dpc-5612	175	19	not	not	PART
dpc-5612	175	20	be	be	AUX
dpc-5612	175	21	generalizable	generalizable	ADJ
dpc-5612	175	22	to	to	ADP
dpc-5612	175	23	regions	region	NOUN
dpc-5612	175	24	with	with	ADP
dpc-5612	175	25	different	different	ADJ
dpc-5612	175	26	radiation	radiation	NOUN
dpc-5612	175	27	levels	level	NOUN
dpc-5612	175	28	.	.	PUNCT
dpc-5612	176	1	furthermore	furthermore	ADV
dpc-5612	176	2	,	,	PUNCT
dpc-5612	176	3	the	the	DET
dpc-5612	176	4	subjects	subject	NOUN
dpc-5612	176	5	included	include	VERB
dpc-5612	176	6	were	be	AUX
dpc-5612	176	7	all	all	ADV
dpc-5612	176	8	caucasian	caucasian	ADJ
dpc-5612	176	9	,	,	PUNCT
dpc-5612	176	10	while	while	SCONJ
dpc-5612	176	11	other	other	ADJ
dpc-5612	176	12	ethnic	ethnic	ADJ
dpc-5612	176	13	groups	group	NOUN
dpc-5612	176	14	were	be	AUX
dpc-5612	176	15	not	not	PART
dpc-5612	176	16	represented	represent	VERB
dpc-5612	176	17	.	.	PUNCT
dpc-5612	177	1	despite	despite	SCONJ
dpc-5612	177	2	these	these	DET
dpc-5612	177	3	limitations	limitation	NOUN
dpc-5612	177	4	,	,	PUNCT
dpc-5612	177	5	this	this	PRON
dpc-5612	177	6	is	be	AUX
dpc-5612	177	7	the	the	DET
dpc-5612	177	8	first	first	ADJ
dpc-5612	177	9	study	study	NOUN
dpc-5612	177	10	to	to	PART
dpc-5612	177	11	specifically	specifically	ADV
dpc-5612	177	12	address	address	VERB
dpc-5612	177	13	the	the	DET
dpc-5612	177	14	use	use	NOUN
dpc-5612	177	15	of	of	ADP
dpc-5612	177	16	oral	oral	ADJ
dpc-5612	177	17	isotretinoin	isotretinoin	NOUN
dpc-5612	177	18	during	during	ADP
dpc-5612	177	19	sunny	sunny	ADJ
dpc-5612	177	20	seasons	season	NOUN
dpc-5612	177	21	,	,	PUNCT
dpc-5612	177	22	with	with	ADP
dpc-5612	177	23	a	a	DET
dpc-5612	177	24	focus	focus	NOUN
dpc-5612	177	25	on	on	ADP
dpc-5612	177	26	its	its	PRON
dpc-5612	177	27	safety	safety	NOUN
dpc-5612	177	28	profile	profile	NOUN
dpc-5612	177	29	.	.	PUNCT
dpc-5612	178	1	the	the	DET
dpc-5612	178	2	study	study	NOUN
dpc-5612	178	3	suggests	suggest	VERB
dpc-5612	178	4	that	that	SCONJ
dpc-5612	178	5	reducing	reduce	VERB
dpc-5612	178	6	the	the	DET
dpc-5612	178	7	daily	daily	ADJ
dpc-5612	178	8	dose	dose	NOUN
dpc-5612	178	9	of	of	ADP
dpc-5612	178	10	oral	oral	ADJ
dpc-5612	178	11	isotretinoin	isotretinoin	PROPN
dpc-5612	178	12	during	during	ADP
dpc-5612	178	13	the	the	DET
dpc-5612	178	14	sunny	sunny	ADJ
dpc-5612	178	15	months	month	NOUN
dpc-5612	178	16	may	may	AUX
dpc-5612	178	17	be	be	AUX
dpc-5612	178	18	a	a	DET
dpc-5612	178	19	reasonable	reasonable	ADJ
dpc-5612	178	20	strategy	strategy	NOUN
dpc-5612	178	21	to	to	PART
dpc-5612	178	22	minimize	minimize	VERB
dpc-5612	178	23	the	the	DET
dpc-5612	178	24	occurrence	occurrence	NOUN
dpc-5612	178	25	of	of	ADP
dpc-5612	178	26	adverse	adverse	ADJ
dpc-5612	178	27	events	event	NOUN
dpc-5612	178	28	.	.	PUNCT
dpc-5612	179	1	based	base	VERB
dpc-5612	179	2	on	on	ADP
dpc-5612	179	3	our	our	PRON
dpc-5612	179	4	findings	finding	NOUN
dpc-5612	179	5	,	,	PUNCT
dpc-5612	179	6	there	there	PRON
dpc-5612	179	7	is	be	VERB
dpc-5612	179	8	no	no	DET
dpc-5612	179	9	evidence	evidence	NOUN
dpc-5612	179	10	to	to	PART
dpc-5612	179	11	support	support	VERB
dpc-5612	179	12	postponing	postpone	VERB
dpc-5612	179	13	the	the	DET
dpc-5612	179	14	start	start	NOUN
dpc-5612	179	15	of	of	ADP
dpc-5612	179	16	treatment	treatment	NOUN
dpc-5612	179	17	until	until	ADP
dpc-5612	179	18	the	the	DET
dpc-5612	179	19	fall	fall	NOUN
dpc-5612	179	20	or	or	CCONJ
dpc-5612	179	21	suspending	suspend	VERB
dpc-5612	179	22	it	it	PRON
dpc-5612	179	23	during	during	ADP
dpc-5612	179	24	the	the	DET
dpc-5612	179	25	summer	summer	NOUN
dpc-5612	179	26	months	month	NOUN
dpc-5612	179	27	.	.	PUNCT
dpc-5612	180	1	on	on	ADP
dpc-5612	180	2	the	the	DET
dpc-5612	180	3	contrary	contrary	NOUN
dpc-5612	180	4	,	,	PUNCT
dpc-5612	180	5	oral	oral	ADJ
dpc-5612	180	6	isotretinoin	isotretinoin	PROPN
dpc-5612	180	7	can	can	AUX
dpc-5612	180	8	be	be	AUX
dpc-5612	180	9	safely	safely	ADV
dpc-5612	180	10	administered	administer	VERB
dpc-5612	180	11	during	during	ADP
dpc-5612	180	12	sunny	sunny	ADJ
dpc-5612	180	13	seasons	season	NOUN
dpc-5612	180	14	to	to	PART
dpc-5612	180	15	reduce	reduce	VERB
dpc-5612	180	16	acne	acne	NOUN
dpc-5612	180	17	severity	severity	NOUN
dpc-5612	180	18	,	,	PUNCT
dpc-5612	180	19	alleviate	alleviate	VERB
dpc-5612	180	20	its	its	PRON
dpc-5612	180	21	emotional	emotional	ADJ
dpc-5612	180	22	burden	burden	NOUN
dpc-5612	180	23	,	,	PUNCT
dpc-5612	180	24	and	and	CCONJ
dpc-5612	180	25	prevent	prevent	VERB
dpc-5612	180	26	scarring	scarring	NOUN
dpc-5612	180	27	,	,	PUNCT
dpc-5612	180	28	which	which	PRON
dpc-5612	180	29	can	can	AUX
dpc-5612	180	30	be	be	AUX
dpc-5612	180	31	worsened	worsen	VERB
dpc-5612	180	32	by	by	ADP
dpc-5612	180	33	delaying	delay	VERB
dpc-5612	180	34	appropriate	appropriate	ADJ
dpc-5612	180	35	treatment	treatment	NOUN
dpc-5612	180	36	.	.	PUNCT
dpc-5612	181	1	while	while	SCONJ
dpc-5612	181	2	reducing	reduce	VERB
dpc-5612	181	3	the	the	DET
dpc-5612	181	4	daily	daily	ADJ
dpc-5612	181	5	dose	dose	NOUN
dpc-5612	181	6	may	may	AUX
dpc-5612	181	7	help	help	VERB
dpc-5612	181	8	mitigate	mitigate	VERB
dpc-5612	181	9	side	side	NOUN
dpc-5612	181	10	effects	effect	NOUN
dpc-5612	181	11	during	during	ADP
dpc-5612	181	12	sunny	sunny	ADJ
dpc-5612	181	13	months	month	NOUN
dpc-5612	181	14	,	,	PUNCT
dpc-5612	181	15	it	it	PRON
dpc-5612	181	16	does	do	AUX
dpc-5612	181	17	not	not	PART
dpc-5612	181	18	appear	appear	VERB
dpc-5612	181	19	to	to	PART
dpc-5612	181	20	compromise	compromise	VERB
dpc-5612	181	21	the	the	DET
dpc-5612	181	22	drug	drug	NOUN
dpc-5612	181	23	's	's	PART
dpc-5612	181	24	therapeutic	therapeutic	ADJ
dpc-5612	181	25	effectiveness	effectiveness	NOUN
dpc-5612	181	26	.	.	PUNCT
dpc-5612	182	1	in	in	ADP
dpc-5612	182	2	conclusion	conclusion	NOUN
dpc-5612	182	3	,	,	PUNCT
dpc-5612	182	4	this	this	DET
dpc-5612	182	5	study	study	NOUN
dpc-5612	182	6	’s	’s	PART
dpc-5612	182	7	results	result	NOUN
dpc-5612	182	8	support	support	VERB
dpc-5612	182	9	the	the	DET
dpc-5612	182	10	use	use	NOUN
dpc-5612	182	11	of	of	ADP
dpc-5612	182	12	oral	oral	ADJ
dpc-5612	182	13	isotretinoin	isotretinoin	NOUN
dpc-5612	182	14	even	even	ADV
dpc-5612	182	15	during	during	ADP
dpc-5612	182	16	high	high	ADJ
dpc-5612	182	17	uv	uv	NOUN
dpc-5612	182	18	radiation	radiation	NOUN
dpc-5612	182	19	seasons	season	NOUN
dpc-5612	182	20	,	,	PUNCT
dpc-5612	182	21	at	at	ADP
dpc-5612	182	22	a	a	DET
dpc-5612	182	23	slightly	slightly	ADV
dpc-5612	182	24	reduced	reduce	VERB
dpc-5612	182	25	daily	daily	ADJ
dpc-5612	182	26	dosage	dosage	NOUN
dpc-5612	182	27	.	.	PUNCT
dpc-5612	183	1	references	reference	NOUN
dpc-5612	183	2	1	1	NUM
dpc-5612	183	3	.	.	PUNCT
dpc-5612	184	1	nast	nast	PROPN
dpc-5612	184	2	a	a	NOUN
dpc-5612	184	3	,	,	PUNCT
dpc-5612	184	4	dréno	dréno	NOUN
dpc-5612	184	5	b	b	NOUN
dpc-5612	184	6	,	,	PUNCT
dpc-5612	184	7	bettoli	bettoli	ADP
dpc-5612	184	8	v	v	NOUN
dpc-5612	184	9	,	,	PUNCT
dpc-5612	184	10	et	et	PROPN
dpc-5612	184	11	al	al	PROPN
dpc-5612	184	12	.	.	PUNCT
dpc-5612	185	1	european	european	ADJ
dpc-5612	185	2	evidence	evidence	NOUN
dpc-5612	185	3	-	-	PUNCT
dpc-5612	185	4	based	base	VERB
dpc-5612	185	5	(	(	PUNCT
dpc-5612	185	6	s3	s3	PROPN
dpc-5612	185	7	)	)	PUNCT
dpc-5612	185	8	guidelines	guideline	NOUN
dpc-5612	185	9	for	for	ADP
dpc-5612	185	10	the	the	DET
dpc-5612	185	11	treatment	treatment	NOUN
dpc-5612	185	12	of	of	ADP
dpc-5612	185	13	acne	acne	NOUN
dpc-5612	185	14	.	.	PUNCT
dpc-5612	186	1	j	j	PROPN
dpc-5612	186	2	eur	eur	PROPN
dpc-5612	186	3	acad	acad	PROPN
dpc-5612	186	4	dermatol	dermatol	NOUN
dpc-5612	186	5	venereol	venereol	NOUN
dpc-5612	186	6	.	.	PUNCT
dpc-5612	187	1	2012;26	2012;26	NUM
dpc-5612	188	1	suppl	suppl	ADJ
dpc-5612	188	2	1(suppl	1(suppl	NUM
dpc-5612	188	3	.	.	PUNCT
dpc-5612	189	1	1):1–29	1):1–29	NUM
dpc-5612	189	2	.	.	PUNCT
dpc-5612	189	3	doi	doi	NOUN
dpc-5612	189	4	:	:	PUNCT
dpc-5612	189	5	10.1111	10.1111	NUM
dpc-5612	189	6	/	/	SYM
dpc-5612	189	7	j	j	PROPN
dpc-5612	189	8	.1468	.1468	PROPN
dpc-5612	189	9	-	-	PUNCT
dpc-5612	189	10	3083.2011.04374.x	3083.2011.04374.x	NUM
dpc-5612	189	11	.	.	PUNCT
dpc-5612	190	1	pmid:22356611	pmid:22356611	ADJ
dpc-5612	190	2	.	.	NOUN
dpc-5612	191	1	2	2	X
dpc-5612	191	2	.	.	X
dpc-5612	191	3	melnik	melnik	PROPN
dpc-5612	191	4	bodo	bodo	PROPN
dpc-5612	191	5	c.	c.	PROPN
dpc-5612	191	6	acne	acne	PROPN
dpc-5612	191	7	transcriptomics	transcriptomic	NOUN
dpc-5612	191	8	:	:	PUNCT
dpc-5612	191	9	fundamentals	fundamental	NOUN
dpc-5612	191	10	of	of	ADP
dpc-5612	191	11	acne	acne	NOUN
dpc-5612	191	12	pathogenesis	pathogenesis	NOUN
dpc-5612	191	13	and	and	CCONJ
dpc-5612	191	14	isotretinoin	isotretinoin	PROPN
dpc-5612	191	15	treatment	treatment	NOUN
dpc-5612	191	16	.	.	PUNCT
dpc-5612	192	1	cells	cell	NOUN
dpc-5612	192	2	.	.	PUNCT
dpc-5612	193	1	2023;12(22	2023;12(22	NUM
dpc-5612	193	2	)	)	PUNCT
dpc-5612	193	3	.	.	PUNCT
dpc-5612	194	1	doi	doi	NOUN
dpc-5612	194	2	:	:	PUNCT
dpc-5612	194	3	10.3390	10.3390	NUM
dpc-5612	194	4	/	/	SYM
dpc-5612	194	5	cells12222600	cells12222600	PROPN
dpc-5612	194	6	.	.	PUNCT
dpc-5612	195	1	pmid:37998335	pmid:37998335	NOUN
dpc-5612	195	2	.	.	PROPN
dpc-5612	196	1	3	3	X
dpc-5612	196	2	.	.	X
dpc-5612	197	1	nast	nast	PROPN
dpc-5612	197	2	a	a	NOUN
dpc-5612	197	3	,	,	PUNCT
dpc-5612	197	4	dréno	dréno	NOUN
dpc-5612	197	5	b	b	NOUN
dpc-5612	197	6	,	,	PUNCT
dpc-5612	197	7	bettoli	bettoli	ADP
dpc-5612	197	8	v	v	NOUN
dpc-5612	197	9	,	,	PUNCT
dpc-5612	197	10	et	et	PROPN
dpc-5612	197	11	al	al	PROPN
dpc-5612	197	12	.	.	PUNCT
dpc-5612	198	1	european	european	ADJ
dpc-5612	198	2	evidence	evidence	NOUN
dpc-5612	198	3	-	-	PUNCT
dpc-5612	198	4	based	base	VERB
dpc-5612	198	5	(	(	PUNCT
dpc-5612	198	6	s3	s3	PROPN
dpc-5612	198	7	)	)	PUNCT
dpc-5612	198	8	guideline	guideline	NOUN
dpc-5612	198	9	for	for	ADP
dpc-5612	198	10	the	the	DET
dpc-5612	198	11	treatment	treatment	NOUN
dpc-5612	198	12	of	of	ADP
dpc-5612	198	13	acne	acne	NOUN
dpc-5612	198	14	update	update	NOUN
dpc-5612	198	15	2016	2016	NUM
dpc-5612	198	16	short	short	ADJ
dpc-5612	198	17	regarding	regard	VERB
dpc-5612	198	18	treatment	treatment	NOUN
dpc-5612	198	19	outcomes	outcome	NOUN
dpc-5612	198	20	,	,	PUNCT
dpc-5612	198	21	a	a	DET
dpc-5612	198	22	significant	significant	ADJ
dpc-5612	198	23	reduction	reduction	NOUN
dpc-5612	198	24	in	in	ADP
dpc-5612	198	25	acne	acne	NOUN
dpc-5612	198	26	severity	severity	NOUN
dpc-5612	198	27	was	be	AUX
dpc-5612	198	28	observed	observe	VERB
dpc-5612	198	29	across	across	ADP
dpc-5612	198	30	all	all	DET
dpc-5612	198	31	anatomical	anatomical	ADJ
dpc-5612	198	32	areas	area	NOUN
dpc-5612	198	33	after	after	ADP
dpc-5612	198	34	oral	oral	ADJ
dpc-5612	198	35	isotretinoin	isotretinoin	PROPN
dpc-5612	198	36	treatment	treatment	NOUN
dpc-5612	198	37	(	(	PUNCT
dpc-5612	198	38	table	table	NOUN
dpc-5612	198	39	2	2	NUM
dpc-5612	198	40	)	)	PUNCT
dpc-5612	198	41	.	.	PUNCT
dpc-5612	199	1	the	the	DET
dpc-5612	199	2	leeds	leed	NOUN
dpc-5612	199	3	revised	revise	VERB
dpc-5612	199	4	acne	acne	NOUN
dpc-5612	199	5	grading	grade	VERB
dpc-5612	199	6	system	system	NOUN
dpc-5612	199	7	scores	score	NOUN
dpc-5612	199	8	showed	show	VERB
dpc-5612	199	9	marked	mark	VERB
dpc-5612	199	10	improvement	improvement	NOUN
dpc-5612	199	11	for	for	ADP
dpc-5612	199	12	facial	facial	ADJ
dpc-5612	199	13	,	,	PUNCT
dpc-5612	199	14	back	back	ADV
dpc-5612	199	15	,	,	PUNCT
dpc-5612	199	16	and	and	CCONJ
dpc-5612	199	17	chest	chest	NOUN
dpc-5612	199	18	acne	acne	NOUN
dpc-5612	199	19	,	,	PUNCT
dpc-5612	199	20	with	with	ADP
dpc-5612	199	21	the	the	DET
dpc-5612	199	22	median	median	ADJ
dpc-5612	199	23	scores	score	NOUN
dpc-5612	199	24	dropping	drop	VERB
dpc-5612	199	25	to	to	ADP
dpc-5612	199	26	near	near	ADV
dpc-5612	199	27	-	-	PUNCT
dpc-5612	199	28	zero	zero	NUM
dpc-5612	199	29	values	value	NOUN
dpc-5612	199	30	post	post	ADJ
dpc-5612	199	31	-	-	NOUN
dpc-5612	199	32	treatment	treatment	ADJ
dpc-5612	199	33	(	(	PUNCT
dpc-5612	199	34	table	table	NOUN
dpc-5612	199	35	2	2	NUM
dpc-5612	199	36	)	)	PUNCT
dpc-5612	199	37	.	.	PUNCT
dpc-5612	200	1	these	these	DET
dpc-5612	200	2	results	result	NOUN
dpc-5612	200	3	were	be	AUX
dpc-5612	200	4	expected	expect	VERB
dpc-5612	200	5	and	and	CCONJ
dpc-5612	200	6	are	be	AUX
dpc-5612	200	7	consistent	consistent	ADJ
dpc-5612	200	8	with	with	ADP
dpc-5612	200	9	numerous	numerous	ADJ
dpc-5612	200	10	previous	previous	ADJ
dpc-5612	200	11	studies	study	NOUN
dpc-5612	200	12	that	that	PRON
dpc-5612	200	13	have	have	AUX
dpc-5612	200	14	demonstrated	demonstrate	VERB
dpc-5612	200	15	the	the	DET
dpc-5612	200	16	effectiveness	effectiveness	NOUN
dpc-5612	200	17	of	of	ADP
dpc-5612	200	18	oral	oral	ADJ
dpc-5612	200	19	isotretinoin	isotretinoin	NOUN
dpc-5612	200	20	in	in	ADP
dpc-5612	200	21	inducing	induce	VERB
dpc-5612	200	22	acne	acne	NOUN
dpc-5612	200	23	remission	remission	NOUN
dpc-5612	200	24	,	,	PUNCT
dpc-5612	200	25	even	even	ADV
dpc-5612	200	26	in	in	ADP
dpc-5612	200	27	severe	severe	ADJ
dpc-5612	200	28	and	and	CCONJ
dpc-5612	200	29	recalcitrant	recalcitrant	ADJ
dpc-5612	200	30	cases	case	NOUN
dpc-5612	200	31	[	[	X
dpc-5612	200	32	3,17–20	3,17–20	NUM
dpc-5612	200	33	]	]	PUNCT
dpc-5612	200	34	.	.	PUNCT
dpc-5612	201	1	the	the	DET
dpc-5612	201	2	complete	complete	ADJ
dpc-5612	201	3	or	or	CCONJ
dpc-5612	201	4	near	near	ADV
dpc-5612	201	5	-	-	PUNCT
dpc-5612	201	6	complete	complete	ADJ
dpc-5612	201	7	resolution	resolution	NOUN
dpc-5612	201	8	of	of	ADP
dpc-5612	201	9	acne	acne	NOUN
dpc-5612	201	10	in	in	ADP
dpc-5612	201	11	most	most	ADJ
dpc-5612	201	12	patients	patient	NOUN
dpc-5612	201	13	is	be	AUX
dpc-5612	201	14	unsurprising	unsurprising	ADJ
dpc-5612	201	15	given	give	VERB
dpc-5612	201	16	the	the	DET
dpc-5612	201	17	unique	unique	ADJ
dpc-5612	201	18	mechanism	mechanism	NOUN
dpc-5612	201	19	of	of	ADP
dpc-5612	201	20	action	action	NOUN
dpc-5612	201	21	of	of	ADP
dpc-5612	201	22	oral	oral	ADJ
dpc-5612	201	23	isotretinoin	isotretinoin	NOUN
dpc-5612	202	1	[	[	X
dpc-5612	202	2	4	4	NUM
dpc-5612	202	3	]	]	PUNCT
dpc-5612	202	4	.	.	PUNCT
dpc-5612	203	1	the	the	DET
dpc-5612	203	2	consistency	consistency	NOUN
dpc-5612	203	3	of	of	ADP
dpc-5612	203	4	these	these	DET
dpc-5612	203	5	outcomes	outcome	NOUN
dpc-5612	203	6	across	across	ADP
dpc-5612	203	7	different	different	ADJ
dpc-5612	203	8	body	body	NOUN
dpc-5612	203	9	sites	site	NOUN
dpc-5612	203	10	further	far	ADV
dpc-5612	203	11	supports	support	VERB
dpc-5612	203	12	its	its	PRON
dpc-5612	203	13	broad	broad	ADJ
dpc-5612	203	14	-	-	PUNCT
dpc-5612	203	15	spectrum	spectrum	NOUN
dpc-5612	203	16	effectiveness	effectiveness	NOUN
dpc-5612	203	17	.	.	PUNCT
dpc-5612	204	1	while	while	SCONJ
dpc-5612	204	2	facial	facial	ADJ
dpc-5612	204	3	acne	acne	NOUN
dpc-5612	204	4	is	be	AUX
dpc-5612	204	5	often	often	ADV
dpc-5612	204	6	the	the	DET
dpc-5612	204	7	primary	primary	ADJ
dpc-5612	204	8	focus	focus	NOUN
dpc-5612	204	9	of	of	ADP
dpc-5612	204	10	treatment	treatment	NOUN
dpc-5612	204	11	,	,	PUNCT
dpc-5612	204	12	acne	acne	NOUN
dpc-5612	204	13	on	on	ADP
dpc-5612	204	14	the	the	DET
dpc-5612	204	15	back	back	NOUN
dpc-5612	204	16	and	and	CCONJ
dpc-5612	204	17	chest	chest	NOUN
dpc-5612	204	18	can	can	AUX
dpc-5612	204	19	be	be	AUX
dpc-5612	204	20	more	more	ADV
dpc-5612	204	21	challenging	challenging	ADJ
dpc-5612	204	22	due	due	ADJ
dpc-5612	204	23	to	to	ADP
dpc-5612	204	24	the	the	DET
dpc-5612	204	25	thicker	thick	ADJ
dpc-5612	204	26	skin	skin	NOUN
dpc-5612	204	27	and	and	CCONJ
dpc-5612	204	28	larger	large	ADJ
dpc-5612	204	29	sebaceous	sebaceous	ADJ
dpc-5612	204	30	glands	gland	NOUN
dpc-5612	204	31	in	in	ADP
dpc-5612	204	32	these	these	DET
dpc-5612	204	33	areas	area	NOUN
dpc-5612	204	34	[	[	X
dpc-5612	204	35	21	21	NUM
dpc-5612	204	36	]	]	PUNCT
dpc-5612	204	37	.	.	PUNCT
dpc-5612	205	1	these	these	DET
dpc-5612	205	2	results	result	NOUN
dpc-5612	205	3	reinforce	reinforce	VERB
dpc-5612	205	4	the	the	DET
dpc-5612	205	5	role	role	NOUN
dpc-5612	205	6	of	of	ADP
dpc-5612	205	7	oral	oral	ADJ
dpc-5612	205	8	isotretinoin	isotretinoin	PROPN
dpc-5612	205	9	as	as	ADP
dpc-5612	205	10	the	the	DET
dpc-5612	205	11	gold	gold	ADJ
dpc-5612	205	12	standard	standard	NOUN
dpc-5612	205	13	in	in	ADP
dpc-5612	205	14	acne	acne	NOUN
dpc-5612	205	15	treatment	treatment	NOUN
dpc-5612	205	16	,	,	PUNCT
dpc-5612	205	17	regardless	regardless	ADV
dpc-5612	205	18	of	of	ADP
dpc-5612	205	19	the	the	DET
dpc-5612	205	20	affected	affected	ADJ
dpc-5612	205	21	body	body	NOUN
dpc-5612	205	22	site	site	NOUN
dpc-5612	205	23	.	.	PUNCT
dpc-5612	206	1	the	the	DET
dpc-5612	206	2	most	most	ADV
dpc-5612	206	3	noteworthy	noteworthy	ADJ
dpc-5612	206	4	aspect	aspect	NOUN
dpc-5612	206	5	of	of	ADP
dpc-5612	206	6	this	this	DET
dpc-5612	206	7	study	study	NOUN
dpc-5612	206	8	,	,	PUNCT
dpc-5612	206	9	which	which	PRON
dpc-5612	206	10	was	be	AUX
dpc-5612	206	11	not	not	PART
dpc-5612	206	12	specifically	specifically	ADV
dpc-5612	206	13	addressed	address	VERB
dpc-5612	206	14	in	in	ADP
dpc-5612	206	15	previous	previous	ADJ
dpc-5612	206	16	research	research	NOUN
dpc-5612	206	17	,	,	PUNCT
dpc-5612	206	18	is	be	AUX
dpc-5612	206	19	its	its	PRON
dpc-5612	206	20	primary	primary	ADJ
dpc-5612	206	21	objective	objective	NOUN
dpc-5612	206	22	,	,	PUNCT
dpc-5612	206	23	i.e.	i.e.	X
dpc-5612	206	24	,	,	PUNCT
dpc-5612	206	25	assessing	assess	VERB
dpc-5612	206	26	the	the	DET
dpc-5612	206	27	safety	safety	NOUN
dpc-5612	206	28	of	of	ADP
dpc-5612	206	29	oral	oral	ADJ
dpc-5612	206	30	isotretinoin	isotretinoin	NOUN
dpc-5612	206	31	when	when	SCONJ
dpc-5612	206	32	administered	administer	VERB
dpc-5612	206	33	during	during	ADP
dpc-5612	206	34	sunny	sunny	ADJ
dpc-5612	206	35	seasons	season	NOUN
dpc-5612	206	36	.	.	PUNCT
dpc-5612	207	1	the	the	DET
dpc-5612	207	2	rates	rate	NOUN
dpc-5612	207	3	of	of	ADP
dpc-5612	207	4	adverse	adverse	ADJ
dpc-5612	207	5	events	event	NOUN
dpc-5612	207	6	observed	observe	VERB
dpc-5612	207	7	during	during	ADP
dpc-5612	207	8	the	the	DET
dpc-5612	207	9	sunny	sunny	ADJ
dpc-5612	207	10	months	month	NOUN
dpc-5612	207	11	were	be	AUX
dpc-5612	207	12	no	no	ADV
dpc-5612	207	13	higher	high	ADJ
dpc-5612	207	14	than	than	ADP
dpc-5612	207	15	those	those	PRON
dpc-5612	207	16	recorded	record	VERB
dpc-5612	207	17	during	during	ADP
dpc-5612	207	18	the	the	DET
dpc-5612	207	19	non	non	ADJ
dpc-5612	207	20	-	-	ADJ
dpc-5612	207	21	sunny	sunny	ADJ
dpc-5612	207	22	periods	period	NOUN
dpc-5612	207	23	.	.	PUNCT
dpc-5612	208	1	in	in	ADP
dpc-5612	208	2	fact	fact	NOUN
dpc-5612	208	3	,	,	PUNCT
dpc-5612	208	4	our	our	PRON
dpc-5612	208	5	experience	experience	NOUN
dpc-5612	208	6	indicates	indicate	VERB
dpc-5612	208	7	that	that	SCONJ
dpc-5612	208	8	the	the	DET
dpc-5612	208	9	incidence	incidence	NOUN
dpc-5612	208	10	of	of	ADP
dpc-5612	208	11	side	side	NOUN
dpc-5612	208	12	effects	effect	NOUN
dpc-5612	208	13	was	be	AUX
dpc-5612	208	14	lower	low	ADJ
dpc-5612	208	15	during	during	ADP
dpc-5612	208	16	the	the	DET
dpc-5612	208	17	sunny	sunny	ADJ
dpc-5612	208	18	months	month	NOUN
dpc-5612	208	19	compared	compare	VERB
dpc-5612	208	20	to	to	ADP
dpc-5612	208	21	the	the	DET
dpc-5612	208	22	rest	rest	NOUN
dpc-5612	208	23	of	of	ADP
dpc-5612	208	24	the	the	DET
dpc-5612	208	25	year	year	NOUN
dpc-5612	208	26	.	.	PUNCT
dpc-5612	209	1	this	this	PRON
dpc-5612	209	2	appears	appear	VERB
dpc-5612	209	3	to	to	PART
dpc-5612	209	4	be	be	AUX
dpc-5612	209	5	attributed	attribute	VERB
dpc-5612	209	6	to	to	ADP
dpc-5612	209	7	the	the	DET
dpc-5612	209	8	reduced	reduce	VERB
dpc-5612	209	9	daily	daily	ADJ
dpc-5612	209	10	dosage	dosage	NOUN
dpc-5612	209	11	of	of	ADP
dpc-5612	209	12	the	the	DET
dpc-5612	209	13	drug	drug	NOUN
dpc-5612	209	14	during	during	ADP
dpc-5612	209	15	the	the	DET
dpc-5612	209	16	sunniest	sunny	ADJ
dpc-5612	209	17	months	month	NOUN
dpc-5612	209	18	,	,	PUNCT
dpc-5612	209	19	as	as	SCONJ
dpc-5612	209	20	adverse	adverse	ADJ
dpc-5612	209	21	events	event	NOUN
dpc-5612	209	22	are	be	AUX
dpc-5612	209	23	known	know	VERB
dpc-5612	209	24	to	to	PART
dpc-5612	209	25	be	be	AUX
dpc-5612	209	26	dose	dose	VERB
dpc-5612	209	27	-	-	PUNCT
dpc-5612	209	28	dependent	dependent	ADJ
dpc-5612	209	29	.	.	PUNCT
dpc-5612	210	1	the	the	DET
dpc-5612	210	2	absence	absence	NOUN
dpc-5612	210	3	of	of	ADP
dpc-5612	210	4	an	an	DET
dpc-5612	210	5	increased	increase	VERB
dpc-5612	210	6	rate	rate	NOUN
dpc-5612	210	7	of	of	ADP
dpc-5612	210	8	drug	drug	NOUN
dpc-5612	210	9	discontinuation	discontinuation	NOUN
dpc-5612	210	10	and	and	CCONJ
dpc-5612	210	11	severe	severe	ADJ
dpc-5612	210	12	adverse	adverse	ADJ
dpc-5612	210	13	events	event	NOUN
dpc-5612	210	14	during	during	ADP
dpc-5612	210	15	the	the	DET
dpc-5612	210	16	summer	summer	NOUN
dpc-5612	210	17	months	month	NOUN
dpc-5612	210	18	further	far	ADV
dpc-5612	210	19	supports	support	VERB
dpc-5612	210	20	the	the	DET
dpc-5612	210	21	notion	notion	NOUN
dpc-5612	210	22	that	that	SCONJ
dpc-5612	210	23	oral	oral	ADJ
dpc-5612	210	24	isotretinoin	isotretinoin	PROPN
dpc-5612	210	25	is	be	AUX
dpc-5612	210	26	neither	neither	CCONJ
dpc-5612	210	27	photoallergic	photoallergic	NOUN
dpc-5612	210	28	nor	nor	CCONJ
dpc-5612	210	29	phototoxic	phototoxic	NOUN
dpc-5612	210	30	.	.	PUNCT
dpc-5612	211	1	while	while	SCONJ
dpc-5612	211	2	patients	patient	NOUN
dpc-5612	211	3	on	on	ADP
dpc-5612	211	4	oral	oral	ADJ
dpc-5612	211	5	isotretinoin	isotretinoin	PROPN
dpc-5612	211	6	may	may	AUX
dpc-5612	211	7	experience	experience	VERB
dpc-5612	211	8	heightened	heighten	VERB
dpc-5612	211	9	skin	skin	NOUN
dpc-5612	211	10	sensitivity	sensitivity	NOUN
dpc-5612	211	11	,	,	PUNCT
dpc-5612	211	12	this	this	DET
dpc-5612	211	13	vulnerability	vulnerability	NOUN
dpc-5612	211	14	is	be	AUX
dpc-5612	211	15	not	not	PART
dpc-5612	211	16	limited	limit	VERB
dpc-5612	211	17	to	to	ADP
dpc-5612	211	18	sun	sun	NOUN
dpc-5612	211	19	exposure	exposure	NOUN
dpc-5612	211	20	;	;	PUNCT
dpc-5612	211	21	it	it	PRON
dpc-5612	211	22	extends	extend	VERB
dpc-5612	211	23	to	to	ADP
dpc-5612	211	24	a	a	DET
dpc-5612	211	25	variety	variety	NOUN
dpc-5612	211	26	of	of	ADP
dpc-5612	211	27	exogenous	exogenous	ADJ
dpc-5612	211	28	irritants	irritant	NOUN
dpc-5612	211	29	at	at	ADP
dpc-5612	211	30	any	any	DET
dpc-5612	211	31	time	time	NOUN
dpc-5612	211	32	of	of	ADP
dpc-5612	211	33	the	the	DET
dpc-5612	211	34	year	year	NOUN
dpc-5612	211	35	.	.	PUNCT
dpc-5612	212	1	this	this	PRON
dpc-5612	212	2	underscores	underscore	VERB
dpc-5612	212	3	the	the	DET
dpc-5612	212	4	importance	importance	NOUN
dpc-5612	212	5	of	of	ADP
dpc-5612	212	6	advising	advise	VERB
dpc-5612	212	7	patients	patient	NOUN
dpc-5612	212	8	to	to	PART
dpc-5612	212	9	adopt	adopt	VERB
dpc-5612	212	10	protective	protective	ADJ
dpc-5612	212	11	measures	measure	NOUN
dpc-5612	212	12	year	year	NOUN
dpc-5612	212	13	-	-	PUNCT
dpc-5612	212	14	round	round	NOUN
dpc-5612	212	15	,	,	PUNCT
dpc-5612	212	16	including	include	VERB
dpc-5612	212	17	emollients	emollient	NOUN
dpc-5612	212	18	for	for	ADP
dpc-5612	212	19	the	the	DET
dpc-5612	212	20	skin	skin	NOUN
dpc-5612	212	21	and	and	CCONJ
dpc-5612	212	22	lips	lip	NOUN
dpc-5612	212	23	,	,	PUNCT
dpc-5612	212	24	gentle	gentle	ADJ
dpc-5612	212	25	cleansing	cleansing	NOUN
dpc-5612	212	26	,	,	PUNCT
dpc-5612	212	27	and	and	CCONJ
dpc-5612	212	28	rigorous	rigorous	ADJ
dpc-5612	212	29	photoprotection	photoprotection	NOUN
dpc-5612	212	30	.	.	PUNCT
dpc-5612	213	1	therefore	therefore	ADV
dpc-5612	213	2	,	,	PUNCT
dpc-5612	213	3	our	our	PRON
dpc-5612	213	4	data	datum	NOUN
dpc-5612	213	5	challenge	challenge	VERB
dpc-5612	213	6	the	the	DET
dpc-5612	213	7	common	common	ADJ
dpc-5612	213	8	practice	practice	NOUN
dpc-5612	213	9	of	of	ADP
dpc-5612	213	10	delaying	delay	VERB
dpc-5612	213	11	oral	oral	ADJ
dpc-5612	213	12	isotretinoin	isotretinoin	PROPN
dpc-5612	213	13	administration	administration	NOUN
dpc-5612	213	14	until	until	ADP
dpc-5612	213	15	after	after	ADP
dpc-5612	213	16	the	the	DET
dpc-5612	213	17	summer	summer	NOUN
dpc-5612	213	18	or	or	CCONJ
dpc-5612	213	19	suspending	suspend	VERB
dpc-5612	213	20	treatment	treatment	NOUN
dpc-5612	213	21	during	during	ADP
dpc-5612	213	22	the	the	DET
dpc-5612	213	23	sunny	sunny	ADJ
dpc-5612	213	24	months	month	NOUN
dpc-5612	213	25	due	due	ADP
dpc-5612	213	26	to	to	ADP
dpc-5612	213	27	concerns	concern	NOUN
dpc-5612	213	28	about	about	ADP
dpc-5612	213	29	sun	sun	NOUN
dpc-5612	213	30	exposure	exposure	NOUN
dpc-5612	213	31	.	.	PUNCT
dpc-5612	214	1	given	give	VERB
dpc-5612	214	2	that	that	SCONJ
dpc-5612	214	3	untreated	untreated	ADJ
dpc-5612	214	4	acne	acne	NOUN
dpc-5612	214	5	can	can	AUX
dpc-5612	214	6	lead	lead	VERB
dpc-5612	214	7	to	to	ADP
dpc-5612	214	8	long	long	ADJ
dpc-5612	214	9	-	-	PUNCT
dpc-5612	214	10	term	term	NOUN
dpc-5612	214	11	scarring	scarring	NOUN
dpc-5612	214	12	,	,	PUNCT
dpc-5612	214	13	postponing	postpone	VERB
dpc-5612	214	14	treatment	treatment	NOUN
dpc-5612	214	15	for	for	ADP
dpc-5612	214	16	several	several	ADJ
dpc-5612	214	17	months	month	NOUN
dpc-5612	214	18	could	could	AUX
dpc-5612	214	19	result	result	VERB
dpc-5612	214	20	in	in	ADP
dpc-5612	214	21	permanent	permanent	ADJ
dpc-5612	214	22	skin	skin	NOUN
dpc-5612	214	23	damage	damage	NOUN
dpc-5612	214	24	[	[	X
dpc-5612	214	25	22	22	NUM
dpc-5612	214	26	]	]	PUNCT
dpc-5612	214	27	.	.	PUNCT
dpc-5612	215	1	instead	instead	ADV
dpc-5612	215	2	,	,	PUNCT
dpc-5612	215	3	initiating	initiate	VERB
dpc-5612	215	4	oral	oral	ADJ
dpc-5612	215	5	isotretinoin	isotretinoin	PROPN
dpc-5612	215	6	treatment	treatment	NOUN
dpc-5612	215	7	promptly	promptly	ADV
dpc-5612	215	8	and	and	CCONJ
dpc-5612	215	9	advising	advise	VERB
dpc-5612	215	10	patients	patient	NOUN
dpc-5612	215	11	on	on	ADP
dpc-5612	215	12	appropriate	appropriate	ADJ
dpc-5612	215	13	skin	skin	NOUN
dpc-5612	215	14	care	care	NOUN
dpc-5612	215	15	can	can	AUX
dpc-5612	215	16	help	help	VERB
dpc-5612	215	17	prevent	prevent	VERB
dpc-5612	215	18	unnecessary	unnecessary	ADJ
dpc-5612	215	19	delays	delay	NOUN
dpc-5612	215	20	in	in	ADP
dpc-5612	215	21	achieving	achieve	VERB
dpc-5612	215	22	acne	acne	NOUN
dpc-5612	215	23	remission	remission	NOUN
dpc-5612	215	24	.	.	PUNCT
dpc-5612	216	1	this	this	DET
dpc-5612	216	2	approach	approach	NOUN
dpc-5612	216	3	also	also	ADV
dpc-5612	216	4	addresses	address	VERB
dpc-5612	216	5	the	the	DET
dpc-5612	216	6	suffering	suffering	NOUN
dpc-5612	216	7	and	and	CCONJ
dpc-5612	216	8	emotional	emotional	ADJ
dpc-5612	216	9	burden	burden	NOUN
dpc-5612	216	10	that	that	PRON
dpc-5612	216	11	acne	acne	NOUN
dpc-5612	216	12	can	can	AUX
dpc-5612	216	13	cause	cause	VERB
dpc-5612	216	14	.	.	PUNCT
dpc-5612	217	1	original	original	ADJ
dpc-5612	217	2	article	article	NOUN
dpc-5612	217	3	|	|	ADV
dpc-5612	217	4	dermatol	dermatol	ADJ
dpc-5612	217	5	pract	pract	NOUN
dpc-5612	217	6	concept	concept	NOUN
dpc-5612	217	7	.	.	PUNCT
dpc-5612	218	1	2025;15(4):5612	2025;15(4):5612	NUM
dpc-5612	218	2	7	7	NUM
dpc-5612	218	3	14	14	NUM
dpc-5612	218	4	.	.	PUNCT
dpc-5612	219	1	bagatin	bagatin	PROPN
dpc-5612	219	2	e	e	PROPN
dpc-5612	219	3	,	,	PUNCT
dpc-5612	219	4	costa	costa	PROPN
dpc-5612	219	5	cs	cs	PROPN
dpc-5612	219	6	.	.	PUNCT
dpc-5612	220	1	the	the	DET
dpc-5612	220	2	use	use	NOUN
dpc-5612	220	3	of	of	ADP
dpc-5612	220	4	isotretinoin	isotretinoin	PROPN
dpc-5612	220	5	for	for	ADP
dpc-5612	220	6	acne	acne	NOUN
dpc-5612	220	7	–	–	PUNCT
dpc-5612	220	8	an	an	DET
dpc-5612	220	9	update	update	NOUN
dpc-5612	220	10	on	on	ADP
dpc-5612	220	11	optimal	optimal	ADJ
dpc-5612	220	12	dosing	dosing	NOUN
dpc-5612	220	13	,	,	PUNCT
dpc-5612	220	14	surveillance	surveillance	NOUN
dpc-5612	220	15	,	,	PUNCT
dpc-5612	220	16	and	and	CCONJ
dpc-5612	220	17	adverse	adverse	ADJ
dpc-5612	220	18	effects	effect	NOUN
dpc-5612	220	19	.	.	PUNCT
dpc-5612	221	1	expert	expert	NOUN
dpc-5612	221	2	rev	rev	PROPN
dpc-5612	221	3	clin	clin	PROPN
dpc-5612	221	4	pharmacol	pharmacol	PROPN
dpc-5612	221	5	.	.	PUNCT
dpc-5612	222	1	2020;13(8):885–97	2020;13(8):885–97	NUM
dpc-5612	222	2	.	.	PUNCT
dpc-5612	223	1	doi	doi	NOUN
dpc-5612	223	2	:	:	PUNCT
dpc-5612	223	3	10.1080/17512433.2020.1796637	10.1080/17512433.2020.1796637	NUM
dpc-5612	223	4	.	.	PUNCT
dpc-5612	223	5	pmid:32744074	pmid:32744074	NOUN
dpc-5612	223	6	.	.	PUNCT
dpc-5612	224	1	15	15	NUM
dpc-5612	224	2	.	.	PUNCT
dpc-5612	225	1	o’brien	o’brien	PROPN
dpc-5612	225	2	sc	sc	PROPN
dpc-5612	225	3	,	,	PUNCT
dpc-5612	225	4	lewis	lewis	PROPN
dpc-5612	225	5	jb	jb	PROPN
dpc-5612	225	6	,	,	PUNCT
dpc-5612	225	7	cunliffe	cunliffe	PROPN
dpc-5612	225	8	wj	wj	PROPN
dpc-5612	225	9	.	.	PUNCT
dpc-5612	226	1	the	the	DET
dpc-5612	226	2	leeds	leed	NOUN
dpc-5612	226	3	revised	revise	VERB
dpc-5612	226	4	acne	acne	NOUN
dpc-5612	226	5	grading	grade	VERB
dpc-5612	226	6	system	system	NOUN
dpc-5612	226	7	.	.	PUNCT
dpc-5612	227	1	j	j	PROPN
dpc-5612	227	2	dermatolog	dermatolog	PROPN
dpc-5612	227	3	treat	treat	NOUN
dpc-5612	227	4	.	.	PUNCT
dpc-5612	228	1	1998;9(4):215–20	1998;9(4):215–20	NUM
dpc-5612	228	2	.	.	PUNCT
dpc-5612	229	1	doi	doi	NOUN
dpc-5612	229	2	:	:	PUNCT
dpc-5612	229	3	10.3109/09546639809160698	10.3109/09546639809160698	NUM
dpc-5612	229	4	.	.	PUNCT
dpc-5612	230	1	16	16	NUM
dpc-5612	230	2	.	.	PUNCT
dpc-5612	231	1	woo	woo	INTJ
dpc-5612	231	2	yr	yr	PROPN
dpc-5612	231	3	,	,	PUNCT
dpc-5612	231	4	kim	kim	PROPN
dpc-5612	231	5	hs	hs	PROPN
dpc-5612	231	6	.	.	PROPN
dpc-5612	231	7	truncal	truncal	ADJ
dpc-5612	231	8	acne	acne	NOUN
dpc-5612	231	9	:	:	PUNCT
dpc-5612	231	10	an	an	DET
dpc-5612	231	11	overview	overview	NOUN
dpc-5612	231	12	.	.	PUNCT
dpc-5612	232	1	j	j	PROPN
dpc-5612	232	2	clin	clin	PROPN
dpc-5612	232	3	med	med	PROPN
dpc-5612	232	4	.	.	PUNCT
dpc-5612	233	1	2022;11(13):3660	2022;11(13):3660	NUM
dpc-5612	233	2	.	.	PUNCT
dpc-5612	234	1	doi	doi	NOUN
dpc-5612	234	2	:	:	PUNCT
dpc-5612	234	3	10.3390	10.3390	NUM
dpc-5612	234	4	/	/	SYM
dpc-5612	234	5	jcm11133660	jcm11133660	NOUN
dpc-5612	234	6	.	.	PUNCT
dpc-5612	235	1	pmid:35806952	pmid:35806952	NOUN
dpc-5612	235	2	.	.	PUNCT
dpc-5612	236	1	17	17	NUM
dpc-5612	236	2	.	.	PUNCT
dpc-5612	237	1	farrell	farrell	PROPN
dpc-5612	237	2	ln	ln	PROPN
dpc-5612	237	3	,	,	PUNCT
dpc-5612	237	4	strauss	strauss	PROPN
dpc-5612	237	5	js	js	PROPN
dpc-5612	237	6	,	,	PUNCT
dpc-5612	237	7	stranieri	stranieri	PROPN
dpc-5612	237	8	am	be	AUX
dpc-5612	237	9	.	.	PUNCT
dpc-5612	238	1	the	the	DET
dpc-5612	238	2	treatment	treatment	NOUN
dpc-5612	238	3	of	of	ADP
dpc-5612	238	4	severe	severe	ADJ
dpc-5612	238	5	cystic	cystic	ADJ
dpc-5612	238	6	acne	acne	NOUN
dpc-5612	238	7	with	with	ADP
dpc-5612	238	8	13	13	NUM
dpc-5612	238	9	-	-	PUNCT
dpc-5612	238	10	cis	cis	NOUN
dpc-5612	238	11	-	-	PUNCT
dpc-5612	238	12	retinoic	retinoic	ADJ
dpc-5612	238	13	acid	acid	NOUN
dpc-5612	238	14	.	.	PUNCT
dpc-5612	239	1	evaluation	evaluation	NOUN
dpc-5612	239	2	of	of	ADP
dpc-5612	239	3	sebum	sebum	NOUN
dpc-5612	239	4	production	production	NOUN
dpc-5612	239	5	and	and	CCONJ
dpc-5612	239	6	the	the	DET
dpc-5612	239	7	clinical	clinical	ADJ
dpc-5612	239	8	response	response	NOUN
dpc-5612	239	9	in	in	ADP
dpc-5612	239	10	a	a	DET
dpc-5612	239	11	multiple	multiple	ADJ
dpc-5612	239	12	-	-	PUNCT
dpc-5612	239	13	dose	dose	NOUN
dpc-5612	239	14	trial	trial	NOUN
dpc-5612	239	15	.	.	PUNCT
dpc-5612	240	1	j	j	PROPN
dpc-5612	240	2	am	be	AUX
dpc-5612	240	3	acad	acad	ADJ
dpc-5612	240	4	dermatol	dermatol	NOUN
dpc-5612	240	5	.	.	PUNCT
dpc-5612	241	1	1980;3(6):602–11	1980;3(6):602–11	NUM
dpc-5612	241	2	.	.	PUNCT
dpc-5612	242	1	doi	doi	NOUN
dpc-5612	242	2	:	:	PUNCT
dpc-5612	242	3	10.1016	10.1016	NUM
dpc-5612	242	4	/	/	SYM
dpc-5612	242	5	s0190	s0190	ADJ
dpc-5612	242	6	-9622(80)80074	-9622(80)80074	NOUN
dpc-5612	242	7	-	-	X
dpc-5612	242	8	0	0	NUM
dpc-5612	242	9	.	.	PUNCT
dpc-5612	243	1	pmid:6451637	pmid:6451637	VERB
dpc-5612	243	2	.	.	PROPN
dpc-5612	243	3	18	18	NUM
dpc-5612	244	1	.	.	PUNCT
dpc-5612	244	2	peck	peck	PROPN
dpc-5612	244	3	gl	gl	PROPN
dpc-5612	244	4	,	,	PUNCT
dpc-5612	244	5	olsen	olsen	NOUN
dpc-5612	244	6	tg	tg	PROPN
dpc-5612	244	7	,	,	PUNCT
dpc-5612	244	8	yoder	yoder	PROPN
dpc-5612	244	9	fw	fw	PROPN
dpc-5612	244	10	,	,	PUNCT
dpc-5612	244	11	et	et	PROPN
dpc-5612	244	12	al	al	PROPN
dpc-5612	244	13	.	.	PROPN
dpc-5612	244	14	prolonged	prolonged	ADJ
dpc-5612	244	15	remissions	remission	NOUN
dpc-5612	244	16	of	of	ADP
dpc-5612	244	17	cystic	cystic	ADJ
dpc-5612	244	18	and	and	CCONJ
dpc-5612	244	19	conglobate	conglobate	ADJ
dpc-5612	244	20	acne	acne	NOUN
dpc-5612	244	21	with	with	ADP
dpc-5612	244	22	13	13	NUM
dpc-5612	244	23	-	-	PUNCT
dpc-5612	244	24	cis	cis	NOUN
dpc-5612	244	25	-	-	PUNCT
dpc-5612	244	26	retinoic	retinoic	NOUN
dpc-5612	244	27	acid	acid	NOUN
dpc-5612	244	28	.	.	PUNCT
dpc-5612	245	1	n	n	PROPN
dpc-5612	245	2	engl	engl	PROPN
dpc-5612	245	3	j	j	PROPN
dpc-5612	245	4	med	med	PROPN
dpc-5612	245	5	.	.	PUNCT
dpc-5612	246	1	1979;300(7):329–33	1979;300(7):329–33	NUM
dpc-5612	246	2	.	.	PUNCT
dpc-5612	246	3	doi	doi	NOUN
dpc-5612	246	4	:	:	PUNCT
dpc-5612	246	5	10.1056	10.1056	NUM
dpc-5612	246	6	/	/	SYM
dpc-5612	246	7	nejm197902153000701	nejm197902153000701	PROPN
dpc-5612	246	8	.	.	PUNCT
dpc-5612	247	1	pmid:153472	pmid:153472	NOUN
dpc-5612	247	2	.	.	PROPN
dpc-5612	248	1	19	19	NUM
dpc-5612	248	2	.	.	PUNCT
dpc-5612	248	3	lee	lee	PROPN
dpc-5612	248	4	jw	jw	PROPN
dpc-5612	248	5	,	,	PUNCT
dpc-5612	248	6	yoo	yoo	PROPN
dpc-5612	248	7	kh	kh	PROPN
dpc-5612	248	8	,	,	PUNCT
dpc-5612	248	9	park	park	PROPN
dpc-5612	248	10	ky	ky	PROPN
dpc-5612	248	11	,	,	PUNCT
dpc-5612	248	12	et	et	PROPN
dpc-5612	248	13	al	al	PROPN
dpc-5612	248	14	.	.	PROPN
dpc-5612	248	15	effectiveness	effectiveness	NOUN
dpc-5612	248	16	of	of	ADP
dpc-5612	248	17	conventional	conventional	ADJ
dpc-5612	248	18	,	,	PUNCT
dpc-5612	248	19	low	low	ADJ
dpc-5612	248	20	-	-	PUNCT
dpc-5612	248	21	dose	dose	NOUN
dpc-5612	248	22	and	and	CCONJ
dpc-5612	248	23	intermittent	intermittent	ADJ
dpc-5612	248	24	oral	oral	ADJ
dpc-5612	248	25	isotretinoin	isotretinoin	NOUN
dpc-5612	248	26	in	in	ADP
dpc-5612	248	27	the	the	DET
dpc-5612	248	28	treatment	treatment	NOUN
dpc-5612	248	29	of	of	ADP
dpc-5612	248	30	acne	acne	NOUN
dpc-5612	248	31	:	:	PUNCT
dpc-5612	248	32	a	a	DET
dpc-5612	248	33	randomized	randomized	ADJ
dpc-5612	248	34	,	,	PUNCT
dpc-5612	248	35	controlled	control	VERB
dpc-5612	248	36	comparative	comparative	ADJ
dpc-5612	248	37	study	study	NOUN
dpc-5612	248	38	.	.	PUNCT
dpc-5612	249	1	br	br	PROPN
dpc-5612	249	2	j	j	PROPN
dpc-5612	249	3	dermatol	dermatol	NOUN
dpc-5612	249	4	.	.	PUNCT
dpc-5612	250	1	2011;164(6):1369–75	2011;164(6):1369–75	X
dpc-5612	250	2	.	.	PUNCT
dpc-5612	250	3	doi	doi	NOUN
dpc-5612	250	4	:	:	PUNCT
dpc-5612	250	5	10.1111	10.1111	NUM
dpc-5612	250	6	/	/	SYM
dpc-5612	250	7	j.1365	j.1365	NOUN
dpc-5612	250	8	-2133.2010.10152.x	-2133.2010.10152.x	ADJ
dpc-5612	250	9	.	.	PUNCT
dpc-5612	251	1	pmid:21114478	pmid:21114478	PROPN
dpc-5612	251	2	.	.	PROPN
dpc-5612	251	3	20	20	NUM
dpc-5612	251	4	.	.	PUNCT
dpc-5612	252	1	reynolds	reynolds	PROPN
dpc-5612	252	2	rv	rv	PROPN
dpc-5612	252	3	,	,	PUNCT
dpc-5612	252	4	yeung	yeung	PROPN
dpc-5612	252	5	h	h	PROPN
dpc-5612	252	6	,	,	PUNCT
dpc-5612	252	7	cheng	cheng	PROPN
dpc-5612	252	8	ce	ce	PROPN
dpc-5612	252	9	,	,	PUNCT
dpc-5612	252	10	et	et	PROPN
dpc-5612	252	11	al	al	PROPN
dpc-5612	252	12	.	.	PUNCT
dpc-5612	252	13	guidelines	guideline	NOUN
dpc-5612	252	14	of	of	ADP
dpc-5612	252	15	care	care	NOUN
dpc-5612	252	16	for	for	ADP
dpc-5612	252	17	the	the	DET
dpc-5612	252	18	management	management	NOUN
dpc-5612	252	19	of	of	ADP
dpc-5612	252	20	acne	acne	NOUN
dpc-5612	252	21	vulgaris	vulgaris	NOUN
dpc-5612	252	22	.	.	PUNCT
dpc-5612	253	1	j	j	PROPN
dpc-5612	253	2	am	be	AUX
dpc-5612	253	3	acad	acad	ADJ
dpc-5612	253	4	dermatol	dermatol	NOUN
dpc-5612	253	5	.	.	PUNCT
dpc-5612	254	1	2024;90(5):1006.e1	2024;90(5):1006.e1	NOUN
dpc-5612	254	2	-	-	PUNCT
dpc-5612	254	3	1006.e30	1006.e30	NUM
dpc-5612	254	4	.	.	PUNCT
dpc-5612	255	1	doi	doi	NOUN
dpc-5612	255	2	:	:	PUNCT
dpc-5612	255	3	10.1016	10.1016	NUM
dpc-5612	255	4	/	/	SYM
dpc-5612	255	5	j.jaad.2023.12.017	j.jaad.2023.12.017	NOUN
dpc-5612	255	6	.	.	PUNCT
dpc-5612	256	1	pmid:38300170	pmid:38300170	NOUN
dpc-5612	256	2	.	.	PUNCT
dpc-5612	257	1	21	21	NUM
dpc-5612	257	2	.	.	PUNCT
dpc-5612	257	3	tan	tan	PROPN
dpc-5612	257	4	j	j	PROPN
dpc-5612	257	5	,	,	PUNCT
dpc-5612	257	6	beissert	beissert	PROPN
dpc-5612	257	7	s	s	PROPN
dpc-5612	257	8	,	,	PUNCT
dpc-5612	257	9	cook	cook	NOUN
dpc-5612	257	10	-	-	PUNCT
dpc-5612	257	11	bolden	bolden	PROPN
dpc-5612	257	12	f	f	PROPN
dpc-5612	257	13	,	,	PUNCT
dpc-5612	257	14	et	et	PROPN
dpc-5612	257	15	al	al	PROPN
dpc-5612	257	16	.	.	PROPN
dpc-5612	257	17	impact	impact	NOUN
dpc-5612	257	18	of	of	ADP
dpc-5612	257	19	facial	facial	ADJ
dpc-5612	257	20	and	and	CCONJ
dpc-5612	257	21	truncal	truncal	ADJ
dpc-5612	257	22	acne	acne	NOUN
dpc-5612	257	23	on	on	ADP
dpc-5612	257	24	quality	quality	NOUN
dpc-5612	257	25	of	of	ADP
dpc-5612	257	26	life	life	NOUN
dpc-5612	257	27	:	:	PUNCT
dpc-5612	257	28	a	a	DET
dpc-5612	257	29	multi	multi	ADJ
dpc-5612	257	30	-	-	ADJ
dpc-5612	257	31	country	country	ADJ
dpc-5612	257	32	population	population	NOUN
dpc-5612	257	33	-	-	PUNCT
dpc-5612	257	34	based	base	VERB
dpc-5612	257	35	survey	survey	NOUN
dpc-5612	257	36	.	.	PUNCT
dpc-5612	258	1	jaad	jaad	NOUN
dpc-5612	258	2	int	int	PROPN
dpc-5612	258	3	.	.	PUNCT
dpc-5612	259	1	2021;3:102–10	2021;3:102–10	X
dpc-5612	259	2	.	.	PUNCT
dpc-5612	260	1	doi	doi	NOUN
dpc-5612	260	2	:	:	PUNCT
dpc-5612	260	3	10.1016	10.1016	NUM
dpc-5612	260	4	/	/	SYM
dpc-5612	260	5	j.jdin.2021.03.002	j.jdin.2021.03.002	PROPN
dpc-5612	260	6	.	.	PUNCT
dpc-5612	260	7	pmid:34409378	pmid:34409378	X
dpc-5612	260	8	.	.	PUNCT
dpc-5612	261	1	22	22	NUM
dpc-5612	261	2	.	.	PUNCT
dpc-5612	262	1	jennings	jennings	PROPN
dpc-5612	262	2	t	t	PROPN
dpc-5612	262	3	,	,	PUNCT
dpc-5612	262	4	duffy	duffy	PROPN
dpc-5612	262	5	r	r	PROPN
dpc-5612	262	6	,	,	PUNCT
dpc-5612	262	7	mclarney	mclarney	NOUN
dpc-5612	262	8	m	m	PROPN
dpc-5612	262	9	,	,	PUNCT
dpc-5612	262	10	et	et	PROPN
dpc-5612	262	11	al	al	PROPN
dpc-5612	262	12	.	.	PROPN
dpc-5612	262	13	acne	acne	PROPN
dpc-5612	262	14	scarring	scarring	NOUN
dpc-5612	262	15	pathophysiology	pathophysiology	NOUN
dpc-5612	262	16	,	,	PUNCT
dpc-5612	262	17	diagnosis	diagnosis	NOUN
dpc-5612	262	18	,	,	PUNCT
dpc-5612	262	19	prevention	prevention	NOUN
dpc-5612	262	20	and	and	CCONJ
dpc-5612	262	21	education	education	NOUN
dpc-5612	262	22	:	:	PUNCT
dpc-5612	262	23	part	part	NOUN
dpc-5612	262	24	i.	i.	PROPN
dpc-5612	262	25	j	j	PROPN
dpc-5612	262	26	am	be	AUX
dpc-5612	262	27	acad	acad	ADJ
dpc-5612	262	28	dermatol	dermatol	NOUN
dpc-5612	262	29	.	.	PUNCT
dpc-5612	263	1	2024;90(6):1123–34.doi	2024;90(6):1123–34.doi	NOUN
dpc-5612	263	2	:	:	PUNCT
dpc-5612	263	3	10.1016	10.1016	NUM
dpc-5612	263	4	/	/	SYM
dpc-5612	263	5	j.	j.	PROPN
dpc-5612	263	6	jaad.2022.04.021	jaad.2022.04.021	PROPN
dpc-5612	263	7	.	.	PROPN
dpc-5612	263	8	pmid:35792196	pmid:35792196	PROPN
dpc-5612	263	9	.	.	PROPN
dpc-5612	263	10	23	23	NUM
dpc-5612	263	11	.	.	PUNCT
dpc-5612	264	1	jones	jones	PROPN
dpc-5612	264	2	dh	dh	PROPN
dpc-5612	264	3	,	,	PUNCT
dpc-5612	264	4	cunliffe	cunliffe	PROPN
dpc-5612	264	5	wj	wj	PROPN
dpc-5612	264	6	.	.	PUNCT
dpc-5612	265	1	remission	remission	NOUN
dpc-5612	265	2	rates	rate	NOUN
dpc-5612	265	3	in	in	ADP
dpc-5612	265	4	acne	acne	NOUN
dpc-5612	265	5	patients	patient	NOUN
dpc-5612	265	6	treated	treat	VERB
dpc-5612	265	7	with	with	ADP
dpc-5612	265	8	various	various	ADJ
dpc-5612	265	9	doses	dose	NOUN
dpc-5612	265	10	of	of	ADP
dpc-5612	265	11	13	13	NUM
dpc-5612	265	12	-	-	PUNCT
dpc-5612	265	13	cis	cis	NOUN
dpc-5612	265	14	-	-	PUNCT
dpc-5612	265	15	retinoic	retinoic	NOUN
dpc-5612	265	16	acid	acid	NOUN
dpc-5612	265	17	(	(	PUNCT
dpc-5612	265	18	isotretinoin	isotretinoin	PROPN
dpc-5612	265	19	)	)	PUNCT
dpc-5612	265	20	.	.	PUNCT
dpc-5612	266	1	br	br	PROPN
dpc-5612	266	2	j	j	PROPN
dpc-5612	266	3	dermatol	dermatol	NOUN
dpc-5612	266	4	.	.	PUNCT
dpc-5612	267	1	1984;111(1):123–5.doi	1984;111(1):123–5.doi	NUM
dpc-5612	267	2	:	:	PUNCT
dpc-5612	267	3	10.1111	10.1111	NUM
dpc-5612	267	4	/	/	SYM
dpc-5612	267	5	j.1365	j.1365	NOUN
dpc-5612	267	6	-	-	PUNCT
dpc-5612	267	7	2133.1984	2133.1984	NOUN
dpc-5612	267	8	.	.	PUNCT
dpc-5612	267	9	tb04030.x	tb04030.x	NOUN
dpc-5612	267	10	.	.	PUNCT
dpc-5612	268	1	pmid:6234915	pmid:6234915	NOUN
dpc-5612	268	2	.	.	PUNCT
dpc-5612	268	3	version	version	NOUN
dpc-5612	268	4	.	.	PUNCT
dpc-5612	269	1	j	j	PROPN
dpc-5612	269	2	eur	eur	PROPN
dpc-5612	269	3	acad	acad	PROPN
dpc-5612	269	4	dermatol	dermatol	NOUN
dpc-5612	269	5	venereol	venereol	NOUN
dpc-5612	269	6	.	.	PUNCT
dpc-5612	270	1	2016;30(8):1261–8	2016;30(8):1261–8	X
dpc-5612	270	2	.	.	PUNCT
dpc-5612	271	1	doi	doi	NOUN
dpc-5612	271	2	:	:	PUNCT
dpc-5612	271	3	10.1111	10.1111	NUM
dpc-5612	271	4	/	/	SYM
dpc-5612	271	5	jdv.13776	jdv.13776	PROPN
dpc-5612	271	6	.	.	PUNCT
dpc-5612	272	1	pmid:27514932	pmid:27514932	VERB
dpc-5612	272	2	.	.	NOUN
dpc-5612	273	1	4	4	X
dpc-5612	273	2	.	.	X
dpc-5612	273	3	villani	villani	PROPN
dpc-5612	273	4	a	a	PROPN
dpc-5612	273	5	,	,	PUNCT
dpc-5612	273	6	nastro	nastro	PROPN
dpc-5612	273	7	f	f	PROPN
dpc-5612	273	8	,	,	PUNCT
dpc-5612	273	9	di	di	PROPN
dpc-5612	273	10	vico	vico	PROPN
dpc-5612	273	11	f	f	PROPN
dpc-5612	273	12	,	,	PUNCT
dpc-5612	273	13	fabbrocini	fabbrocini	NOUN
dpc-5612	273	14	g	g	NOUN
dpc-5612	273	15	,	,	PUNCT
dpc-5612	273	16	annunziata	annunziata	PROPN
dpc-5612	273	17	mc	mc	PROPN
dpc-5612	273	18	,	,	PUNCT
dpc-5612	273	19	genco	genco	PROPN
dpc-5612	273	20	l.	l.	PROPN
dpc-5612	273	21	oral	oral	PROPN
dpc-5612	273	22	isotretinoin	isotretinoin	PROPN
dpc-5612	273	23	for	for	ADP
dpc-5612	273	24	acne	acne	NOUN
dpc-5612	273	25	:	:	PUNCT
dpc-5612	273	26	a	a	DET
dpc-5612	273	27	complete	complete	ADJ
dpc-5612	273	28	overview	overview	NOUN
dpc-5612	273	29	.	.	PUNCT
dpc-5612	274	1	expert	expert	NOUN
dpc-5612	274	2	opin	opin	NOUN
dpc-5612	274	3	drug	drug	NOUN
dpc-5612	274	4	saf	saf	PROPN
dpc-5612	274	5	.	.	PROPN
dpc-5612	274	6	2022;21(8):1027–37	2022;21(8):1027–37	NOUN
dpc-5612	274	7	.	.	PUNCT
dpc-5612	275	1	doi	doi	NOUN
dpc-5612	275	2	:	:	PUNCT
dpc-5612	275	3	10.1080/14740338.2022.2102605	10.1080/14740338.2022.2102605	NUM
dpc-5612	275	4	.	.	PUNCT
dpc-5612	276	1	pmid:35852102	pmid:35852102	PROPN
dpc-5612	276	2	.	.	PROPN
dpc-5612	276	3	5	5	NUM
dpc-5612	276	4	.	.	X
dpc-5612	276	5	ornelas	ornelas	PROPN
dpc-5612	276	6	j	j	PROPN
dpc-5612	276	7	,	,	PUNCT
dpc-5612	276	8	rosamilia	rosamilia	PROPN
dpc-5612	276	9	l	l	PROPN
dpc-5612	276	10	,	,	PUNCT
dpc-5612	276	11	larsen	larsen	PROPN
dpc-5612	276	12	l	l	PROPN
dpc-5612	276	13	,	,	PUNCT
dpc-5612	276	14	et	et	PROPN
dpc-5612	276	15	al	al	PROPN
dpc-5612	276	16	.	.	PROPN
dpc-5612	276	17	objective	objective	ADJ
dpc-5612	276	18	assessment	assessment	NOUN
dpc-5612	276	19	of	of	ADP
dpc-5612	276	20	isotretinoin	isotretinoin	PROPN
dpc-5612	276	21	-	-	PUNCT
dpc-5612	276	22	associated	associate	VERB
dpc-5612	276	23	cheilitis	cheilitis	NOUN
dpc-5612	276	24	:	:	PUNCT
dpc-5612	276	25	isotretinoin	isotretinoin	PROPN
dpc-5612	276	26	cheilitis	cheilitis	NOUN
dpc-5612	276	27	grading	grading	NOUN
dpc-5612	276	28	scale	scale	NOUN
dpc-5612	276	29	.	.	PUNCT
dpc-5612	277	1	j	j	PROPN
dpc-5612	277	2	dermatolog	dermatolog	PROPN
dpc-5612	277	3	treat	treat	NOUN
dpc-5612	277	4	.	.	PUNCT
dpc-5612	278	1	2016;27(2):153–5	2016;27(2):153–5	NUM
dpc-5612	278	2	.	.	PUNCT
dpc-5612	279	1	doi	doi	NOUN
dpc-5612	279	2	:	:	PUNCT
dpc-5612	279	3	10.3109/09546634.2015.1086477	10.3109/09546634.2015.1086477	NUM
dpc-5612	279	4	.	.	PUNCT
dpc-5612	280	1	pmid:26395167	pmid:26395167	ADJ
dpc-5612	280	2	.	.	NOUN
dpc-5612	281	1	6	6	X
dpc-5612	281	2	.	.	X
dpc-5612	281	3	ferguson	ferguson	PROPN
dpc-5612	281	4	j	j	PROPN
dpc-5612	281	5	,	,	PUNCT
dpc-5612	281	6	johnson	johnson	PROPN
dpc-5612	281	7	b.	b.	PROPN
dpc-5612	281	8	e.	e.	PROPN
dpc-5612	281	9	photosensitivity	photosensitivity	PROPN
dpc-5612	281	10	due	due	ADP
dpc-5612	281	11	to	to	ADP
dpc-5612	281	12	retinoids	retinoid	NOUN
dpc-5612	281	13	:	:	PUNCT
dpc-5612	281	14	clinical	clinical	ADJ
dpc-5612	281	15	and	and	CCONJ
dpc-5612	281	16	laboratory	laboratory	NOUN
dpc-5612	281	17	studies	study	NOUN
dpc-5612	281	18	.	.	PUNCT
dpc-5612	282	1	br	br	PROPN
dpc-5612	282	2	j	j	PROPN
dpc-5612	282	3	dermatol	dermatol	NOUN
dpc-5612	282	4	.	.	PUNCT
dpc-5612	283	1	1986;115(3):275–83	1986;115(3):275–83	X
dpc-5612	283	2	.	.	PUNCT
dpc-5612	283	3	doi	doi	NOUN
dpc-5612	283	4	:	:	PUNCT
dpc-5612	283	5	10.1111	10.1111	NUM
dpc-5612	283	6	/	/	SYM
dpc-5612	283	7	j.1365	j.1365	NOUN
dpc-5612	283	8	-	-	PUNCT
dpc-5612	283	9	2133.1986.tb05742.x	2133.1986.tb05742.x	NUM
dpc-5612	283	10	.	.	PUNCT
dpc-5612	284	1	pmid:3530309	pmid:3530309	NOUN
dpc-5612	284	2	.	.	PUNCT
dpc-5612	285	1	7	7	X
dpc-5612	285	2	.	.	X
dpc-5612	285	3	mccormack	mccormack	PROPN
dpc-5612	285	4	leah	leah	PROPN
dpc-5612	285	5	s	s	PROPN
dpc-5612	285	6	,	,	PUNCT
dpc-5612	285	7	turner	turner	PROPN
dpc-5612	285	8	maria	maria	PROPN
dpc-5612	285	9	l.c	l.c	PROPN
dpc-5612	285	10	.	.	PROPN
dpc-5612	285	11	photosensitivity	photosensitivity	PROPN
dpc-5612	285	12	and	and	CCONJ
dpc-5612	285	13	isotretinoin	isotretinoin	PROPN
dpc-5612	285	14	therapy	therapy	NOUN
dpc-5612	285	15	.	.	PUNCT
dpc-5612	286	1	j	j	PROPN
dpc-5612	286	2	am	be	AUX
dpc-5612	286	3	acad	acad	ADJ
dpc-5612	286	4	dermatol	dermatol	NOUN
dpc-5612	286	5	.	.	PUNCT
dpc-5612	287	1	1983;9(2):273–4	1983;9(2):273–4	NUM
dpc-5612	287	2	.	.	PUNCT
dpc-5612	288	1	doi	doi	NOUN
dpc-5612	288	2	:	:	PUNCT
dpc-5612	288	3	10.1016	10.1016	NUM
dpc-5612	288	4	/	/	SYM
dpc-5612	288	5	s0190	s0190	VERB
dpc-5612	288	6	-	-	PUNCT
dpc-5612	288	7	9622(83)80146	9622(83)80146	NUM
dpc-5612	288	8	-	-	PUNCT
dpc-5612	288	9	7	7	NUM
dpc-5612	288	10	.	.	NUM
dpc-5612	288	11	pmid:6577038	pmid:6577038	NOUN
dpc-5612	288	12	.	.	PUNCT
dpc-5612	289	1	8	8	NUM
dpc-5612	289	2	.	.	NUM
dpc-5612	289	3	auffret	auffret	PROPN
dpc-5612	289	4	n	n	CCONJ
dpc-5612	289	5	,	,	PUNCT
dpc-5612	289	6	bruley	bruley	ADJ
dpc-5612	289	7	c	c	PROPN
dpc-5612	289	8	,	,	PUNCT
dpc-5612	289	9	brunetiere	brunetiere	PROPN
dpc-5612	289	10	ra	ra	PROPN
dpc-5612	289	11	,	,	PUNCT
dpc-5612	289	12	decot	decot	PROPN
dpc-5612	289	13	mc	mc	PROPN
dpc-5612	289	14	,	,	PUNCT
dpc-5612	289	15	binet	binet	PROPN
dpc-5612	289	16	o.	o.	PROPN
dpc-5612	289	17	photoaggravated	photoaggravate	VERB
dpc-5612	289	18	allergic	allergic	ADJ
dpc-5612	289	19	reaction	reaction	NOUN
dpc-5612	289	20	to	to	ADP
dpc-5612	289	21	isotretinoin	isotretinoin	PROPN
dpc-5612	289	22	.	.	PUNCT
dpc-5612	290	1	j	j	PROPN
dpc-5612	290	2	am	be	AUX
dpc-5612	290	3	acad	acad	ADJ
dpc-5612	290	4	dermatol	dermatol	NOUN
dpc-5612	290	5	.	.	PUNCT
dpc-5612	291	1	1990;23(2	1990;23(2	NUM
dpc-5612	291	2	pt	pt	NOUN
dpc-5612	291	3	1):321–2	1):321–2	NUM
dpc-5612	291	4	.	.	PUNCT
dpc-5612	292	1	doi	doi	NOUN
dpc-5612	292	2	:	:	PUNCT
dpc-5612	292	3	10.1016	10.1016	NUM
dpc-5612	292	4	/	/	SYM
dpc-5612	292	5	s0190	s0190	VERB
dpc-5612	292	6	-	-	PUNCT
dpc-5612	292	7	9622(08)81245	9622(08)81245	NUM
dpc-5612	292	8	-	-	PUNCT
dpc-5612	292	9	5	5	NUM
dpc-5612	292	10	.	.	PUNCT
dpc-5612	292	11	pmid:2145327	pmid:2145327	NOUN
dpc-5612	292	12	.	.	PUNCT
dpc-5612	293	1	9	9	NUM
dpc-5612	293	2	.	.	X
dpc-5612	293	3	boaz	boaz	PROPN
dpc-5612	293	4	a	a	PROPN
dpc-5612	293	5	,	,	PUNCT
dpc-5612	293	6	grunwald	grunwald	PROPN
dpc-5612	293	7	mh	mh	PROPN
dpc-5612	293	8	,	,	PUNCT
dpc-5612	293	9	livni	livni	PROPN
dpc-5612	293	10	e	e	PROPN
dpc-5612	293	11	,	,	PUNCT
dpc-5612	293	12	halevy	halevy	PROPN
dpc-5612	293	13	s.	s.	PROPN
dpc-5612	293	14	photosensitivity	photosensitivity	PROPN
dpc-5612	293	15	due	due	ADP
dpc-5612	293	16	to	to	ADP
dpc-5612	293	17	isotretinoin	isotretinoin	PROPN
dpc-5612	293	18	:	:	PUNCT
dpc-5612	293	19	a	a	DET
dpc-5612	293	20	possible	possible	ADJ
dpc-5612	293	21	allergic	allergic	ADJ
dpc-5612	293	22	mechanism	mechanism	NOUN
dpc-5612	293	23	.	.	PUNCT
dpc-5612	294	1	j	j	PROPN
dpc-5612	294	2	eur	eur	PROPN
dpc-5612	294	3	acad	acad	PROPN
dpc-5612	294	4	dermatology	dermatology	NOUN
dpc-5612	294	5	venereol	venereol	NOUN
dpc-5612	294	6	.	.	PUNCT
dpc-5612	295	1	1993;2(1):27–30	1993;2(1):27–30	X
dpc-5612	295	2	.	.	PUNCT
dpc-5612	296	1	doi	doi	NOUN
dpc-5612	296	2	:	:	PUNCT
dpc-5612	296	3	10.1111	10.1111	NUM
dpc-5612	296	4	/	/	SYM
dpc-5612	296	5	j.1468	j.1468	NOUN
dpc-5612	296	6	-3083.1993.tb00006.x	-3083.1993.tb00006.x	PUNCT
dpc-5612	296	7	.	.	PUNCT
dpc-5612	296	8	.	.	PUNCT
dpc-5612	297	1	10	10	NUM
dpc-5612	297	2	.	.	X
dpc-5612	298	1	diffey	diffey	PROPN
dpc-5612	298	2	bl	bl	PROPN
dpc-5612	298	3	,	,	PUNCT
dpc-5612	298	4	spiro	spiro	PROPN
dpc-5612	298	5	jg	jg	PROPN
dpc-5612	298	6	,	,	PUNCT
dpc-5612	298	7	hindson	hindson	PROPN
dpc-5612	298	8	tc	tc	PROPN
dpc-5612	298	9	.	.	PUNCT
dpc-5612	298	10	photosensitivity	photosensitivity	NOUN
dpc-5612	298	11	studies	study	NOUN
dpc-5612	298	12	and	and	CCONJ
dpc-5612	298	13	isotretinoin	isotretinoin	PROPN
dpc-5612	298	14	therapy	therapy	NOUN
dpc-5612	298	15	.	.	PUNCT
dpc-5612	299	1	j	j	PROPN
dpc-5612	299	2	am	be	AUX
dpc-5612	299	3	acad	acad	ADJ
dpc-5612	299	4	dermatol	dermatol	NOUN
dpc-5612	299	5	.	.	PUNCT
dpc-5612	300	1	1985;12(1	1985;12(1	NUM
dpc-5612	300	2	pt	pt	PROPN
dpc-5612	300	3	1):119	1):119	NUM
dpc-5612	300	4	–	–	PUNCT
dpc-5612	300	5	21	21	NUM
dpc-5612	300	6	.	.	PUNCT
dpc-5612	301	1	doi	doi	NOUN
dpc-5612	301	2	:	:	PUNCT
dpc-5612	301	3	10.1016	10.1016	NUM
dpc-5612	301	4	/	/	SYM
dpc-5612	301	5	s0190	s0190	VERB
dpc-5612	301	6	-	-	PUNCT
dpc-5612	301	7	9622(85)80248	9622(85)80248	NUM
dpc-5612	301	8	-	-	SYM
dpc-5612	301	9	6	6	NUM
dpc-5612	301	10	.	.	PUNCT
dpc-5612	301	11	pmid:3156899	pmid:3156899	NOUN
dpc-5612	301	12	.	.	PUNCT
dpc-5612	302	1	11	11	NUM
dpc-5612	302	2	.	.	PUNCT
dpc-5612	302	3	wong	wong	PROPN
dpc-5612	302	4	rc	rc	PROPN
dpc-5612	302	5	,	,	PUNCT
dpc-5612	302	6	gilbert	gilbert	PROPN
dpc-5612	302	7	m	m	PROPN
dpc-5612	302	8	,	,	PUNCT
dpc-5612	302	9	woo	woo	VERB
dpc-5612	302	10	ty	ty	PRON
dpc-5612	302	11	,	,	PUNCT
dpc-5612	302	12	kang	kang	PROPN
dpc-5612	302	13	s	s	PROPN
dpc-5612	302	14	,	,	PUNCT
dpc-5612	302	15	petersen	petersen	PROPN
dpc-5612	302	16	c	c	PROPN
dpc-5612	302	17	,	,	PUNCT
dpc-5612	302	18	ellis	ellis	PROPN
dpc-5612	302	19	cn	cn	PROPN
dpc-5612	302	20	.	.	PROPN
dpc-5612	302	21	photosensitivity	photosensitivity	NOUN
dpc-5612	302	22	and	and	CCONJ
dpc-5612	302	23	isotretinoin	isotretinoin	PROPN
dpc-5612	302	24	therapy	therapy	NOUN
dpc-5612	302	25	.	.	PUNCT
dpc-5612	303	1	j	j	PROPN
dpc-5612	303	2	am	be	AUX
dpc-5612	303	3	acad	acad	ADJ
dpc-5612	303	4	dermatol	dermatol	NOUN
dpc-5612	303	5	.	.	PUNCT
dpc-5612	304	1	1986;14(6):1095–6.doi	1986;14(6):1095–6.doi	NUM
dpc-5612	304	2	:	:	PUNCT
dpc-5612	304	3	10.1016	10.1016	NUM
dpc-5612	304	4	/	/	SYM
dpc-5612	304	5	s0190	s0190	VERB
dpc-5612	304	6	-	-	PUNCT
dpc-5612	304	7	9622(86)80199	9622(86)80199	NOUN
dpc-5612	304	8	-	-	PUNCT
dpc-5612	304	9	2	2	NUM
dpc-5612	304	10	.	.	PUNCT
dpc-5612	304	11	pmid:2941460	pmid:2941460	PROPN
dpc-5612	304	12	.	.	PROPN
dpc-5612	305	1	12	12	NUM
dpc-5612	305	2	.	.	PUNCT
dpc-5612	306	1	borghi	borghi	PROPN
dpc-5612	306	2	a	a	PRON
dpc-5612	306	3	,	,	PUNCT
dpc-5612	306	4	mantovani	mantovani	PROPN
dpc-5612	306	5	l	l	NOUN
dpc-5612	306	6	,	,	PUNCT
dpc-5612	306	7	minghetti	minghetti	PROPN
dpc-5612	306	8	s	s	PROPN
dpc-5612	306	9	,	,	PUNCT
dpc-5612	306	10	giari	giari	PROPN
dpc-5612	306	11	s	s	PROPN
dpc-5612	306	12	,	,	PUNCT
dpc-5612	306	13	virgili	virgili	NOUN
dpc-5612	306	14	a	a	PRON
dpc-5612	306	15	,	,	PUNCT
dpc-5612	306	16	bettoli	bettoli	ADV
dpc-5612	306	17	v.	v.	ADP
dpc-5612	306	18	low	low	ADJ
dpc-5612	306	19	-	-	PUNCT
dpc-5612	306	20	cumulative	cumulative	NOUN
dpc-5612	306	21	dose	dose	NOUN
dpc-5612	306	22	isotretinoin	isotretinoin	PROPN
dpc-5612	306	23	treatment	treatment	NOUN
dpc-5612	306	24	in	in	ADP
dpc-5612	306	25	mild	mild	ADJ
dpc-5612	306	26	-	-	PUNCT
dpc-5612	306	27	to	to	ADP
dpc-5612	306	28	-	-	PUNCT
dpc-5612	306	29	moderate	moderate	ADJ
dpc-5612	306	30	acne	acne	NOUN
dpc-5612	306	31	:	:	PUNCT
dpc-5612	306	32	efficacy	efficacy	NOUN
dpc-5612	306	33	in	in	ADP
dpc-5612	306	34	achieving	achieve	VERB
dpc-5612	306	35	stable	stable	ADJ
dpc-5612	306	36	remission	remission	NOUN
dpc-5612	306	37	.	.	PUNCT
dpc-5612	307	1	j	j	PROPN
dpc-5612	307	2	eur	eur	PROPN
dpc-5612	307	3	acad	acad	PROPN
dpc-5612	307	4	dermatol	dermatol	NOUN
dpc-5612	307	5	venereol	venereol	NOUN
dpc-5612	307	6	.	.	PUNCT
dpc-5612	308	1	2011;25(9):1094–8.doi:10.1111	2011;25(9):1094–8.doi:10.1111	NUM
dpc-5612	308	2	/	/	SYM
dpc-5612	308	3	j.1468	j.1468	PROPN
dpc-5612	308	4	-3083.2010.03933.x	-3083.2010.03933.x	PROPN
dpc-5612	308	5	.	.	PUNCT
dpc-5612	309	1	pmid:21198947	pmid:21198947	PROPN
dpc-5612	309	2	.	.	PROPN
dpc-5612	309	3	13	13	NUM
dpc-5612	309	4	.	.	PUNCT
dpc-5612	310	1	borghi	borghi	PROPN
dpc-5612	310	2	a	a	PRON
dpc-5612	310	3	,	,	PUNCT
dpc-5612	310	4	mantovani	mantovani	PROPN
dpc-5612	310	5	l	l	NOUN
dpc-5612	310	6	,	,	PUNCT
dpc-5612	310	7	minghetti	minghetti	PROPN
dpc-5612	310	8	s	s	PROPN
dpc-5612	310	9	,	,	PUNCT
dpc-5612	310	10	virgili	virgili	NOUN
dpc-5612	310	11	a	a	PRON
dpc-5612	310	12	,	,	PUNCT
dpc-5612	310	13	bettoli	bettoli	ADV
dpc-5612	310	14	v.	v.	ADP
dpc-5612	310	15	acute	acute	ADJ
dpc-5612	310	16	acne	acne	NOUN
dpc-5612	310	17	flare	flare	NOUN
dpc-5612	310	18	following	follow	VERB
dpc-5612	310	19	isotretinoin	isotretinoin	PROPN
dpc-5612	310	20	administration	administration	PROPN
dpc-5612	310	21	:	:	PUNCT
dpc-5612	310	22	potential	potential	ADJ
dpc-5612	310	23	protective	protective	ADJ
dpc-5612	310	24	role	role	NOUN
dpc-5612	310	25	of	of	ADP
dpc-5612	310	26	low	low	ADJ
dpc-5612	310	27	starting	starting	NOUN
dpc-5612	310	28	dose	dose	NOUN
dpc-5612	310	29	.	.	PUNCT
dpc-5612	311	1	dermatology	dermatology	NOUN
dpc-5612	311	2	.	.	PUNCT
dpc-5612	312	1	2009:178–80	2009:178–80	NUM
dpc-5612	312	2	.	.	PUNCT
dpc-5612	313	1	doi	doi	NOUN
dpc-5612	313	2	:	:	PUNCT
dpc-5612	313	3	10.1159/000182270	10.1159/000182270	NUM
dpc-5612	313	4	.	.	PUNCT
dpc-5612	314	1	pmid:19060474	pmid:19060474	PROPN
dpc-5612	314	2	.	.	PUNCT