id	sid	tid	token	lemma	pos
dpc-571	1	1	dermatology	dermatology	NOUN
dpc-571	1	2	:	:	PUNCT
dpc-571	1	3	practical	practical	ADJ
dpc-571	1	4	and	and	CCONJ
dpc-571	1	5	conceptual	conceptual	ADJ
dpc-571	1	6	10	10	NUM
dpc-571	1	7	review	review	NOUN
dpc-571	1	8	|	|	ADV
dpc-571	1	9	dermatol	dermatol	ADJ
dpc-571	1	10	pract	pract	NOUN
dpc-571	1	11	concept	concept	NOUN
dpc-571	1	12	2019;9(1):3	2019;9(1):3	NUM
dpc-571	1	13	dermatology	dermatology	NOUN
dpc-571	1	14	practical	practical	ADJ
dpc-571	1	15	&	&	CCONJ
dpc-571	1	16	conceptual	conceptual	ADJ
dpc-571	1	17	familial	familial	ADJ
dpc-571	1	18	melanoma	melanoma	NOUN
dpc-571	1	19	:	:	PUNCT
dpc-571	1	20	diagnostic	diagnostic	ADJ
dpc-571	1	21	and	and	CCONJ
dpc-571	1	22	management	management	NOUN
dpc-571	1	23	implications	implication	NOUN
dpc-571	1	24	mariarita	mariarita	PROPN
dpc-571	1	25	rossi1	rossi1	PROPN
dpc-571	1	26	,	,	PUNCT
dpc-571	1	27	cristina	cristina	PROPN
dpc-571	1	28	pellegrini1	pellegrini1	PROPN
dpc-571	1	29	,	,	PUNCT
dpc-571	1	30	ludovica	ludovica	PROPN
dpc-571	1	31	cardelli1	cardelli1	PROPN
dpc-571	1	32	,	,	PUNCT
dpc-571	1	33	valeria	valeria	PROPN
dpc-571	1	34	ciciarelli1	ciciarelli1	NOUN
dpc-571	1	35	,	,	PUNCT
dpc-571	1	36	lucia	lucia	PROPN
dpc-571	1	37	di	di	PROPN
dpc-571	1	38	nardo1,2	nardo1,2	PROPN
dpc-571	1	39	,	,	PUNCT
dpc-571	1	40	maria	maria	PROPN
dpc-571	1	41	concetta	concetta	PROPN
dpc-571	1	42	fargnoli1	fargnoli1	PROPN
dpc-571	1	43	1	1	NUM
dpc-571	1	44	department	department	NOUN
dpc-571	1	45	of	of	ADP
dpc-571	1	46	dermatology	dermatology	NOUN
dpc-571	1	47	,	,	PUNCT
dpc-571	1	48	discab	discab	NOUN
dpc-571	1	49	,	,	PUNCT
dpc-571	1	50	university	university	NOUN
dpc-571	1	51	of	of	ADP
dpc-571	1	52	l’aquila	l’aquila	PROPN
dpc-571	1	53	,	,	PUNCT
dpc-571	1	54	l’aquila	l’aquila	PROPN
dpc-571	1	55	,	,	PUNCT
dpc-571	1	56	italy	italy	PROPN
dpc-571	1	57	2	2	NUM
dpc-571	1	58	institute	institute	PROPN
dpc-571	1	59	of	of	ADP
dpc-571	1	60	dermatology	dermatology	NOUN
dpc-571	1	61	,	,	PUNCT
dpc-571	1	62	catholic	catholic	PROPN
dpc-571	1	63	university	university	PROPN
dpc-571	1	64	,	,	PUNCT
dpc-571	1	65	rome	rome	PROPN
dpc-571	1	66	,	,	PUNCT
dpc-571	1	67	italy	italy	PROPN
dpc-571	1	68	key	key	ADJ
dpc-571	1	69	words	word	NOUN
dpc-571	1	70	:	:	PUNCT
dpc-571	1	71	familial	familial	ADJ
dpc-571	1	72	melanoma	melanoma	NOUN
dpc-571	1	73	,	,	PUNCT
dpc-571	1	74	cdkn2a	cdkn2a	PROPN
dpc-571	1	75	,	,	PUNCT
dpc-571	1	76	cdk4	cdk4	NOUN
dpc-571	1	77	,	,	PUNCT
dpc-571	1	78	genetic	genetic	ADJ
dpc-571	1	79	testing	testing	NOUN
dpc-571	1	80	,	,	PUNCT
dpc-571	1	81	genetic	genetic	ADJ
dpc-571	1	82	counseling	counseling	NOUN
dpc-571	1	83	,	,	PUNCT
dpc-571	1	84	cancer	cancer	NOUN
dpc-571	1	85	screening	screening	NOUN
dpc-571	1	86	citation	citation	NOUN
dpc-571	1	87	:	:	PUNCT
dpc-571	1	88	rossi	rossi	PROPN
dpc-571	1	89	m	m	PROPN
dpc-571	1	90	,	,	PUNCT
dpc-571	1	91	pellegrini	pellegrini	PROPN
dpc-571	1	92	c	c	PROPN
dpc-571	1	93	,	,	PUNCT
dpc-571	1	94	cardelli	cardelli	PROPN
dpc-571	1	95	l	l	NOUN
dpc-571	1	96	,	,	PUNCT
dpc-571	1	97	ciciarelli	ciciarelli	PROPN
dpc-571	1	98	v	v	NOUN
dpc-571	1	99	,	,	PUNCT
dpc-571	1	100	di	di	NOUN
dpc-571	1	101	nardo	nardo	PROPN
dpc-571	1	102	l	l	PROPN
dpc-571	1	103	,	,	PUNCT
dpc-571	1	104	fargnoli	fargnoli	PROPN
dpc-571	1	105	mc	mc	PROPN
dpc-571	1	106	.	.	PROPN
dpc-571	2	1	familial	familial	ADJ
dpc-571	2	2	melanoma	melanoma	NOUN
dpc-571	2	3	:	:	PUNCT
dpc-571	2	4	diagnostic	diagnostic	ADJ
dpc-571	2	5	and	and	CCONJ
dpc-571	2	6	management	management	NOUN
dpc-571	2	7	implications	implication	NOUN
dpc-571	2	8	.	.	PUNCT
dpc-571	3	1	dermatol	dermatol	NOUN
dpc-571	3	2	pract	pract	PROPN
dpc-571	3	3	concept	concept	NOUN
dpc-571	3	4	.	.	PUNCT
dpc-571	4	1	2019;9(1):10	2019;9(1):10	NUM
dpc-571	4	2	-	-	SYM
dpc-571	4	3	16	16	NUM
dpc-571	4	4	.	.	PUNCT
dpc-571	5	1	doi	doi	NOUN
dpc-571	5	2	:	:	PUNCT
dpc-571	5	3	https://doi.org/10.5826/dpc.0901a03	https://doi.org/10.5826/dpc.0901a03	ADJ
dpc-571	5	4	published	publish	VERB
dpc-571	5	5	:	:	PUNCT
dpc-571	5	6	january	january	PROPN
dpc-571	5	7	31	31	NUM
dpc-571	5	8	,	,	PUNCT
dpc-571	5	9	2019	2019	NUM
dpc-571	5	10	copyright	copyright	NOUN
dpc-571	5	11	:	:	PUNCT
dpc-571	5	12	©	©	PROPN
dpc-571	5	13	2019	2019	NUM
dpc-571	5	14	rossi	rossi	ADJ
dpc-571	5	15	et	et	PROPN
dpc-571	5	16	 	 	SPACE
dpc-571	5	17	al	al	PROPN
dpc-571	5	18	.	.	PUNCT
dpc-571	6	1	this	this	PRON
dpc-571	6	2	is	be	AUX
dpc-571	6	3	an	an	DET
dpc-571	6	4	open	open	ADJ
dpc-571	6	5	-	-	PUNCT
dpc-571	6	6	access	access	NOUN
dpc-571	6	7	article	article	NOUN
dpc-571	6	8	distributed	distribute	VERB
dpc-571	6	9	under	under	ADP
dpc-571	6	10	the	the	DET
dpc-571	6	11	terms	term	NOUN
dpc-571	6	12	of	of	ADP
dpc-571	6	13	the	the	DET
dpc-571	6	14	creative	creative	ADJ
dpc-571	6	15	commons	common	NOUN
dpc-571	6	16	attribution	attribution	NOUN
dpc-571	6	17	license	license	NOUN
dpc-571	6	18	,	,	PUNCT
dpc-571	6	19	which	which	PRON
dpc-571	6	20	permits	permit	VERB
dpc-571	6	21	unrestricted	unrestricted	ADJ
dpc-571	6	22	use	use	NOUN
dpc-571	6	23	,	,	PUNCT
dpc-571	6	24	distribution	distribution	NOUN
dpc-571	6	25	,	,	PUNCT
dpc-571	6	26	and	and	CCONJ
dpc-571	6	27	reproduction	reproduction	NOUN
dpc-571	6	28	in	in	ADP
dpc-571	6	29	any	any	DET
dpc-571	6	30	medium	medium	NOUN
dpc-571	6	31	,	,	PUNCT
dpc-571	6	32	provided	provide	VERB
dpc-571	6	33	the	the	DET
dpc-571	6	34	original	original	ADJ
dpc-571	6	35	author	author	NOUN
dpc-571	6	36	and	and	CCONJ
dpc-571	6	37	source	source	NOUN
dpc-571	6	38	are	be	AUX
dpc-571	6	39	credited	credit	VERB
dpc-571	6	40	.	.	PUNCT
dpc-571	7	1	funding	funding	NOUN
dpc-571	7	2	:	:	PUNCT
dpc-571	7	3	none	none	NOUN
dpc-571	7	4	.	.	PUNCT
dpc-571	8	1	competing	compete	VERB
dpc-571	8	2	interests	interest	NOUN
dpc-571	8	3	:	:	PUNCT
dpc-571	8	4	the	the	DET
dpc-571	8	5	authors	author	NOUN
dpc-571	8	6	have	have	VERB
dpc-571	8	7	no	no	DET
dpc-571	8	8	conflicts	conflict	NOUN
dpc-571	8	9	of	of	ADP
dpc-571	8	10	interest	interest	NOUN
dpc-571	8	11	to	to	PART
dpc-571	8	12	disclose	disclose	VERB
dpc-571	8	13	.	.	PUNCT
dpc-571	9	1	authorship	authorship	NOUN
dpc-571	9	2	:	:	PUNCT
dpc-571	9	3	all	all	DET
dpc-571	9	4	authors	author	NOUN
dpc-571	9	5	have	have	AUX
dpc-571	9	6	contributed	contribute	VERB
dpc-571	9	7	significantly	significantly	ADV
dpc-571	9	8	to	to	ADP
dpc-571	9	9	this	this	DET
dpc-571	9	10	publication	publication	NOUN
dpc-571	9	11	.	.	PUNCT
dpc-571	10	1	corresponding	correspond	VERB
dpc-571	10	2	author	author	NOUN
dpc-571	10	3	:	:	PUNCT
dpc-571	10	4	prof	prof	PROPN
dpc-571	10	5	.	.	PUNCT
dpc-571	11	1	maria	maria	PROPN
dpc-571	11	2	concetta	concetta	PROPN
dpc-571	11	3	fargnoli	fargnoli	PROPN
dpc-571	11	4	,	,	PUNCT
dpc-571	11	5	department	department	NOUN
dpc-571	11	6	of	of	ADP
dpc-571	11	7	dermatology	dermatology	NOUN
dpc-571	11	8	,	,	PUNCT
dpc-571	11	9	discab	discab	NOUN
dpc-571	11	10	,	,	PUNCT
dpc-571	11	11	university	university	NOUN
dpc-571	11	12	of	of	ADP
dpc-571	11	13	l’aquila	l’aquila	PROPN
dpc-571	11	14	,	,	PUNCT
dpc-571	11	15	via	via	ADP
dpc-571	11	16	vetoio	vetoio	ADJ
dpc-571	11	17	,	,	PUNCT
dpc-571	11	18	coppito	coppito	ADJ
dpc-571	11	19	2	2	NUM
dpc-571	11	20	,	,	PUNCT
dpc-571	11	21	67100	67100	NUM
dpc-571	11	22	l’aquila	l’aquila	PROPN
dpc-571	11	23	,	,	PUNCT
dpc-571	11	24	italy	italy	PROPN
dpc-571	11	25	.	.	PUNCT
dpc-571	12	1	email	email	PROPN
dpc-571	12	2	:	:	PUNCT
dpc-571	12	3	mariaconcetta.fargnoli@univaq.it	mariaconcetta.fargnoli@univaq.it	PROPN
dpc-571	12	4	background	background	NOUN
dpc-571	12	5	:	:	PUNCT
dpc-571	12	6	an	an	DET
dpc-571	12	7	estimated	estimate	VERB
dpc-571	12	8	5%-10	5%-10	NUM
dpc-571	12	9	%	%	NOUN
dpc-571	12	10	of	of	ADP
dpc-571	12	11	all	all	DET
dpc-571	12	12	cutaneous	cutaneous	ADJ
dpc-571	12	13	melanoma	melanoma	NOUN
dpc-571	12	14	cases	case	NOUN
dpc-571	12	15	occur	occur	VERB
dpc-571	12	16	in	in	ADP
dpc-571	12	17	families	family	NOUN
dpc-571	12	18	.	.	PUNCT
dpc-571	13	1	this	this	DET
dpc-571	13	2	review	review	NOUN
dpc-571	13	3	describes	describe	VERB
dpc-571	13	4	susceptibility	susceptibility	NOUN
dpc-571	13	5	genes	gene	NOUN
dpc-571	13	6	currently	currently	ADV
dpc-571	13	7	known	know	VERB
dpc-571	13	8	to	to	PART
dpc-571	13	9	be	be	AUX
dpc-571	13	10	involved	involve	VERB
dpc-571	13	11	in	in	ADP
dpc-571	13	12	melanoma	melanoma	NOUN
dpc-571	13	13	predisposition	predisposition	NOUN
dpc-571	13	14	,	,	PUNCT
dpc-571	13	15	genetic	genetic	ADJ
dpc-571	13	16	testing	testing	NOUN
dpc-571	13	17	of	of	ADP
dpc-571	13	18	familial	familial	ADJ
dpc-571	13	19	melanoma	melanoma	NOUN
dpc-571	13	20	patients	patient	NOUN
dpc-571	13	21	,	,	PUNCT
dpc-571	13	22	and	and	CCONJ
dpc-571	13	23	management	management	NOUN
dpc-571	13	24	implications	implication	NOUN
dpc-571	13	25	.	.	PUNCT
dpc-571	14	1	results	result	NOUN
dpc-571	14	2	:	:	PUNCT
dpc-571	14	3	cdkn2a	cdkn2a	X
dpc-571	14	4	is	be	AUX
dpc-571	14	5	the	the	DET
dpc-571	14	6	major	major	ADJ
dpc-571	14	7	high	high	ADJ
dpc-571	14	8	-	-	PUNCT
dpc-571	14	9	penetrance	penetrance	NOUN
dpc-571	14	10	susceptibility	susceptibility	NOUN
dpc-571	14	11	gene	gene	NOUN
dpc-571	14	12	with	with	ADP
dpc-571	14	13	germline	germline	NOUN
dpc-571	14	14	mutations	mutation	NOUN
dpc-571	14	15	identified	identify	VERB
dpc-571	14	16	in	in	ADP
dpc-571	14	17	20%-40	20%-40	NUM
dpc-571	14	18	%	%	NOUN
dpc-571	14	19	of	of	ADP
dpc-571	14	20	melanoma	melanoma	NOUN
dpc-571	14	21	families	family	NOUN
dpc-571	14	22	.	.	PUNCT
dpc-571	15	1	a	a	DET
dpc-571	15	2	positive	positive	ADJ
dpc-571	15	3	cdkn2a	cdkn2a	PROPN
dpc-571	15	4	mutation	mutation	NOUN
dpc-571	15	5	status	status	NOUN
dpc-571	15	6	has	have	AUX
dpc-571	15	7	been	be	AUX
dpc-571	15	8	associated	associate	VERB
dpc-571	15	9	with	with	ADP
dpc-571	15	10	a	a	DET
dpc-571	15	11	high	high	ADJ
dpc-571	15	12	number	number	NOUN
dpc-571	15	13	of	of	ADP
dpc-571	15	14	affected	affect	VERB
dpc-571	15	15	family	family	NOUN
dpc-571	15	16	members	member	NOUN
dpc-571	15	17	,	,	PUNCT
dpc-571	15	18	multiple	multiple	ADJ
dpc-571	15	19	primary	primary	ADJ
dpc-571	15	20	melanomas	melanomas	NOUN
dpc-571	15	21	,	,	PUNCT
dpc-571	15	22	pancreatic	pancreatic	ADJ
dpc-571	15	23	cancer	cancer	NOUN
dpc-571	15	24	,	,	PUNCT
dpc-571	15	25	and	and	CCONJ
dpc-571	15	26	early	early	ADJ
dpc-571	15	27	age	age	NOUN
dpc-571	15	28	at	at	ADP
dpc-571	15	29	melanoma	melanoma	NOUN
dpc-571	15	30	onset	onset	NOUN
dpc-571	15	31	.	.	PUNCT
dpc-571	16	1	mutations	mutation	NOUN
dpc-571	16	2	in	in	ADP
dpc-571	16	3	the	the	DET
dpc-571	16	4	other	other	ADJ
dpc-571	16	5	melanoma	melanoma	NOUN
dpc-571	16	6	predisposition	predisposition	NOUN
dpc-571	16	7	genes	gene	NOUN
dpc-571	16	8	—	—	PUNCT
dpc-571	16	9	cdk4	cdk4	NOUN
dpc-571	16	10	,	,	PUNCT
dpc-571	16	11	bap1	bap1	PROPN
dpc-571	16	12	,	,	PUNCT
dpc-571	16	13	tert	tert	NOUN
dpc-571	16	14	,	,	PUNCT
dpc-571	16	15	pot1	pot1	PROPN
dpc-571	16	16	,	,	PUNCT
dpc-571	16	17	acd	acd	PROPN
dpc-571	16	18	,	,	PUNCT
dpc-571	16	19	terf2ip	terf2ip	PROPN
dpc-571	16	20	,	,	PUNCT
dpc-571	16	21	and	and	CCONJ
dpc-571	16	22	mitf	mitf	NOUN
dpc-571	16	23	—	—	PUNCT
dpc-571	16	24	are	be	AUX
dpc-571	16	25	rare	rare	ADJ
dpc-571	16	26	,	,	PUNCT
dpc-571	16	27	overall	overall	ADV
dpc-571	16	28	contributing	contribute	VERB
dpc-571	16	29	to	to	PART
dpc-571	16	30	explain	explain	VERB
dpc-571	16	31	a	a	DET
dpc-571	16	32	further	further	ADJ
dpc-571	16	33	10	10	NUM
dpc-571	16	34	%	%	NOUN
dpc-571	16	35	of	of	ADP
dpc-571	16	36	familial	familial	ADJ
dpc-571	16	37	clustering	clustering	NOUN
dpc-571	16	38	of	of	ADP
dpc-571	16	39	melanoma	melanoma	NOUN
dpc-571	16	40	.	.	PUNCT
dpc-571	17	1	the	the	DET
dpc-571	17	2	underlying	underlying	ADJ
dpc-571	17	3	genetic	genetic	ADJ
dpc-571	17	4	susceptibility	susceptibility	NOUN
dpc-571	17	5	remains	remain	VERB
dpc-571	17	6	indeed	indeed	ADV
dpc-571	17	7	unexplained	unexplained	ADJ
dpc-571	17	8	for	for	ADP
dpc-571	17	9	half	half	NOUN
dpc-571	17	10	of	of	ADP
dpc-571	17	11	melanoma	melanoma	NOUN
dpc-571	17	12	families	family	NOUN
dpc-571	17	13	.	.	PUNCT
dpc-571	18	1	genetic	genetic	ADJ
dpc-571	18	2	testing	testing	NOUN
dpc-571	18	3	for	for	ADP
dpc-571	18	4	melanoma	melanoma	NOUN
dpc-571	18	5	is	be	AUX
dpc-571	18	6	currently	currently	ADV
dpc-571	18	7	recommended	recommend	VERB
dpc-571	18	8	only	only	ADV
dpc-571	18	9	for	for	ADP
dpc-571	18	10	cdkn2a	cdkn2a	PROPN
dpc-571	18	11	and	and	CCONJ
dpc-571	18	12	cdk4	cdk4	NOUN
dpc-571	18	13	,	,	PUNCT
dpc-571	18	14	and	and	CCONJ
dpc-571	18	15	,	,	PUNCT
dpc-571	18	16	at	at	ADP
dpc-571	18	17	this	this	DET
dpc-571	18	18	time	time	NOUN
dpc-571	18	19	,	,	PUNCT
dpc-571	18	20	the	the	DET
dpc-571	18	21	role	role	NOUN
dpc-571	18	22	of	of	ADP
dpc-571	18	23	multigene	multigene	ADJ
dpc-571	18	24	panel	panel	NOUN
dpc-571	18	25	testing	testing	NOUN
dpc-571	18	26	remains	remain	VERB
dpc-571	18	27	under	under	ADP
dpc-571	18	28	debate	debate	NOUN
dpc-571	18	29	.	.	PUNCT
dpc-571	19	1	individuals	individual	NOUN
dpc-571	19	2	from	from	ADP
dpc-571	19	3	melanoma	melanoma	NOUN
dpc-571	19	4	families	family	NOUN
dpc-571	19	5	must	must	AUX
dpc-571	19	6	receive	receive	VERB
dpc-571	19	7	genetic	genetic	ADJ
dpc-571	19	8	counseling	counseling	NOUN
dpc-571	19	9	to	to	PART
dpc-571	19	10	be	be	AUX
dpc-571	19	11	informed	inform	VERB
dpc-571	19	12	about	about	ADP
dpc-571	19	13	the	the	DET
dpc-571	19	14	inclusion	inclusion	NOUN
dpc-571	19	15	criteria	criterion	NOUN
dpc-571	19	16	for	for	ADP
dpc-571	19	17	genetic	genetic	ADJ
dpc-571	19	18	testing	testing	NOUN
dpc-571	19	19	,	,	PUNCT
dpc-571	19	20	the	the	DET
dpc-571	19	21	probability	probability	NOUN
dpc-571	19	22	of	of	ADP
dpc-571	19	23	an	an	DET
dpc-571	19	24	inconclusive	inconclusive	ADJ
dpc-571	19	25	result	result	NOUN
dpc-571	19	26	,	,	PUNCT
dpc-571	19	27	the	the	DET
dpc-571	19	28	genetic	genetic	ADJ
dpc-571	19	29	risk	risk	NOUN
dpc-571	19	30	for	for	ADP
dpc-571	19	31	melanoma	melanoma	NOUN
dpc-571	19	32	and	and	CCONJ
dpc-571	19	33	other	other	ADJ
dpc-571	19	34	cancers	cancer	NOUN
dpc-571	19	35	,	,	PUNCT
dpc-571	19	36	and	and	CCONJ
dpc-571	19	37	the	the	DET
dpc-571	19	38	debatable	debatable	ADJ
dpc-571	19	39	role	role	NOUN
dpc-571	19	40	of	of	ADP
dpc-571	19	41	medical	medical	ADJ
dpc-571	19	42	management	management	NOUN
dpc-571	19	43	.	.	PUNCT
dpc-571	20	1	they	they	PRON
dpc-571	20	2	should	should	AUX
dpc-571	20	3	be	be	AUX
dpc-571	20	4	counseled	counsel	VERB
dpc-571	20	5	focusing	focus	VERB
dpc-571	20	6	primarily	primarily	ADV
dpc-571	20	7	on	on	ADP
dpc-571	20	8	recommendations	recommendation	NOUN
dpc-571	20	9	on	on	ADP
dpc-571	20	10	appropriate	appropriate	ADJ
dpc-571	20	11	lifestyle	lifestyle	NOUN
dpc-571	20	12	,	,	PUNCT
dpc-571	20	13	encouraging	encourage	VERB
dpc-571	20	14	skin	skin	NOUN
dpc-571	20	15	self	self	NOUN
dpc-571	20	16	-	-	PUNCT
dpc-571	20	17	examination	examination	NOUN
dpc-571	20	18	,	,	PUNCT
dpc-571	20	19	and	and	CCONJ
dpc-571	20	20	regular	regular	ADJ
dpc-571	20	21	dermatological	dermatological	ADJ
dpc-571	20	22	screening	screening	NOUN
dpc-571	20	23	.	.	PUNCT
dpc-571	21	1	conclusions	conclusion	NOUN
dpc-571	21	2	:	:	PUNCT
dpc-571	21	3	genetic	genetic	ADJ
dpc-571	21	4	testing	testing	NOUN
dpc-571	21	5	for	for	ADP
dpc-571	21	6	high	high	ADJ
dpc-571	21	7	-	-	PUNCT
dpc-571	21	8	penetrance	penetrance	NOUN
dpc-571	21	9	melanoma	melanoma	NOUN
dpc-571	21	10	susceptibility	susceptibility	NOUN
dpc-571	21	11	genes	gene	NOUN
dpc-571	21	12	is	be	AUX
dpc-571	21	13	recommended	recommend	VERB
dpc-571	21	14	in	in	ADP
dpc-571	21	15	melanoma	melanoma	NOUN
dpc-571	21	16	families	family	NOUN
dpc-571	21	17	after	after	ADP
dpc-571	21	18	selection	selection	NOUN
dpc-571	21	19	of	of	ADP
dpc-571	21	20	the	the	DET
dpc-571	21	21	appropriate	appropriate	ADJ
dpc-571	21	22	candidates	candidate	NOUN
dpc-571	21	23	and	and	CCONJ
dpc-571	21	24	adequate	adequate	ADJ
dpc-571	21	25	counseling	counseling	NOUN
dpc-571	21	26	of	of	ADP
dpc-571	21	27	the	the	DET
dpc-571	21	28	patient	patient	NOUN
dpc-571	21	29	.	.	PUNCT
dpc-571	22	1	all	all	DET
dpc-571	22	2	patients	patient	NOUN
dpc-571	22	3	and	and	CCONJ
dpc-571	22	4	relatives	relative	NOUN
dpc-571	22	5	from	from	ADP
dpc-571	22	6	melanoma	melanoma	NOUN
dpc-571	22	7	kindreds	kindred	NOUN
dpc-571	22	8	,	,	PUNCT
dpc-571	22	9	irrespective	irrespective	ADV
dpc-571	22	10	of	of	ADP
dpc-571	22	11	their	their	PRON
dpc-571	22	12	mutation	mutation	NOUN
dpc-571	22	13	status	status	NOUN
dpc-571	22	14	,	,	PUNCT
dpc-571	22	15	should	should	AUX
dpc-571	22	16	be	be	AUX
dpc-571	22	17	encouraged	encourage	VERB
dpc-571	22	18	to	to	PART
dpc-571	22	19	adhere	adhere	VERB
dpc-571	22	20	to	to	ADP
dpc-571	22	21	a	a	DET
dpc-571	22	22	correct	correct	ADJ
dpc-571	22	23	ultraviolet	ultraviolet	ADJ
dpc-571	22	24	exposure	exposure	NOUN
dpc-571	22	25	,	,	PUNCT
dpc-571	22	26	skin	skin	NOUN
dpc-571	22	27	self	self	NOUN
dpc-571	22	28	-	-	PUNCT
dpc-571	22	29	examination	examination	NOUN
dpc-571	22	30	,	,	PUNCT
dpc-571	22	31	and	and	CCONJ
dpc-571	22	32	surveillance	surveillance	NOUN
dpc-571	22	33	by	by	ADP
dpc-571	22	34	physicians	physician	NOUN
dpc-571	22	35	.	.	PUNCT
dpc-571	23	1	abstract	abstract	ADJ
dpc-571	23	2	review	review	NOUN
dpc-571	23	3	|	|	ADV
dpc-571	23	4	dermatol	dermatol	ADJ
dpc-571	23	5	pract	pract	NOUN
dpc-571	23	6	concept	concept	NOUN
dpc-571	23	7	2019;9(1):3	2019;9(1):3	PROPN
dpc-571	23	8	11	11	NUM
dpc-571	23	9	ing	ing	ADJ
dpc-571	23	10	,	,	PUNCT
dpc-571	23	11	the	the	DET
dpc-571	23	12	probability	probability	NOUN
dpc-571	23	13	of	of	ADP
dpc-571	23	14	an	an	DET
dpc-571	23	15	inconclusive	inconclusive	ADJ
dpc-571	23	16	result	result	NOUN
dpc-571	23	17	,	,	PUNCT
dpc-571	23	18	the	the	DET
dpc-571	23	19	genetic	genetic	ADJ
dpc-571	23	20	risk	risk	NOUN
dpc-571	23	21	for	for	ADP
dpc-571	23	22	melanoma	melanoma	NOUN
dpc-571	23	23	and	and	CCONJ
dpc-571	23	24	other	other	ADJ
dpc-571	23	25	cancers	cancer	NOUN
dpc-571	23	26	,	,	PUNCT
dpc-571	23	27	and	and	CCONJ
dpc-571	23	28	the	the	DET
dpc-571	23	29	debatable	debatable	ADJ
dpc-571	23	30	role	role	NOUN
dpc-571	23	31	of	of	ADP
dpc-571	23	32	medical	medical	ADJ
dpc-571	23	33	management	management	NOUN
dpc-571	23	34	.	.	PUNCT
dpc-571	24	1	this	this	DET
dpc-571	24	2	review	review	NOUN
dpc-571	24	3	describes	describe	VERB
dpc-571	24	4	susceptibility	susceptibility	NOUN
dpc-571	24	5	genes	gene	NOUN
dpc-571	24	6	known	know	VERB
dpc-571	24	7	to	to	PART
dpc-571	24	8	be	be	AUX
dpc-571	24	9	involved	involve	VERB
dpc-571	24	10	in	in	ADP
dpc-571	24	11	melanoma	melanoma	NOUN
dpc-571	24	12	predisposition	predisposition	NOUN
dpc-571	24	13	,	,	PUNCT
dpc-571	24	14	genetic	genetic	ADJ
dpc-571	24	15	testing	testing	NOUN
dpc-571	24	16	of	of	ADP
dpc-571	24	17	familial	familial	ADJ
dpc-571	24	18	melanoma	melanoma	NOUN
dpc-571	24	19	patients	patient	NOUN
dpc-571	24	20	,	,	PUNCT
dpc-571	24	21	and	and	CCONJ
dpc-571	24	22	management	management	NOUN
dpc-571	24	23	implications	implication	NOUN
dpc-571	24	24	.	.	PUNCT
dpc-571	25	1	melanoma	melanoma	NOUN
dpc-571	25	2	susceptibility	susceptibility	NOUN
dpc-571	25	3	genes	gene	NOUN
dpc-571	25	4	unlike	unlike	ADP
dpc-571	25	5	other	other	ADJ
dpc-571	25	6	cancer	cancer	NOUN
dpc-571	25	7	predisposition	predisposition	NOUN
dpc-571	25	8	syndromes	syndrome	NOUN
dpc-571	25	9	,	,	PUNCT
dpc-571	25	10	melanoma	melanoma	NOUN
dpc-571	25	11	is	be	AUX
dpc-571	25	12	not	not	PART
dpc-571	25	13	linked	link	VERB
dpc-571	25	14	to	to	ADP
dpc-571	25	15	a	a	DET
dpc-571	25	16	single	single	ADJ
dpc-571	25	17	gene	gene	NOUN
dpc-571	25	18	,	,	PUNCT
dpc-571	25	19	but	but	CCONJ
dpc-571	25	20	several	several	ADJ
dpc-571	25	21	highand	highand	ADJ
dpc-571	25	22	intermediatepenetrance	intermediatepenetrance	NOUN
dpc-571	25	23	melanoma	melanoma	NOUN
dpc-571	25	24	susceptibility	susceptibility	NOUN
dpc-571	25	25	genes	gene	NOUN
dpc-571	25	26	have	have	AUX
dpc-571	25	27	been	be	AUX
dpc-571	25	28	identified	identify	VERB
dpc-571	25	29	to	to	ADP
dpc-571	25	30	date	date	NOUN
dpc-571	25	31	(	(	PUNCT
dpc-571	25	32	table	table	NOUN
dpc-571	25	33	1	1	NUM
dpc-571	25	34	)	)	PUNCT
dpc-571	25	35	.	.	PUNCT
dpc-571	26	1	penetrance	penetrance	NOUN
dpc-571	26	2	relates	relate	VERB
dpc-571	26	3	to	to	ADP
dpc-571	26	4	the	the	DET
dpc-571	26	5	lifetime	lifetime	NOUN
dpc-571	26	6	risk	risk	NOUN
dpc-571	26	7	for	for	ADP
dpc-571	26	8	a	a	DET
dpc-571	26	9	mutation	mutation	NOUN
dpc-571	26	10	carrier	carrier	NOUN
dpc-571	26	11	of	of	ADP
dpc-571	26	12	developing	develop	VERB
dpc-571	26	13	melanoma	melanoma	NOUN
dpc-571	26	14	and	and	CCONJ
dpc-571	26	15	reflects	reflect	VERB
dpc-571	26	16	the	the	DET
dpc-571	26	17	overall	overall	ADJ
dpc-571	26	18	contribution	contribution	NOUN
dpc-571	26	19	of	of	ADP
dpc-571	26	20	a	a	DET
dpc-571	26	21	specific	specific	ADJ
dpc-571	26	22	gene	gene	NOUN
dpc-571	26	23	alteration	alteration	NOUN
dpc-571	26	24	to	to	ADP
dpc-571	26	25	the	the	DET
dpc-571	26	26	risk	risk	NOUN
dpc-571	26	27	of	of	ADP
dpc-571	26	28	melanoma	melanoma	NOUN
dpc-571	26	29	.	.	PUNCT
dpc-571	27	1	high	high	ADJ
dpc-571	27	2	-	-	PUNCT
dpc-571	27	3	penetrance	penetrance	NOUN
dpc-571	27	4	genes	gene	NOUN
dpc-571	27	5	cdkn2a	cdkn2a	VERB
dpc-571	27	6	was	be	AUX
dpc-571	27	7	the	the	DET
dpc-571	27	8	first	first	ADJ
dpc-571	27	9	familial	familial	ADJ
dpc-571	27	10	melanoma	melanoma	NOUN
dpc-571	27	11	predisposition	predisposition	NOUN
dpc-571	27	12	gene	gene	NOUN
dpc-571	27	13	to	to	PART
dpc-571	27	14	be	be	AUX
dpc-571	27	15	identified	identify	VERB
dpc-571	27	16	and	and	CCONJ
dpc-571	27	17	is	be	AUX
dpc-571	27	18	mutated	mutate	VERB
dpc-571	27	19	in	in	ADP
dpc-571	27	20	approximately	approximately	ADV
dpc-571	27	21	20%40	20%40	NUM
dpc-571	27	22	%	%	NOUN
dpc-571	27	23	of	of	ADP
dpc-571	27	24	high	high	ADJ
dpc-571	27	25	-	-	PUNCT
dpc-571	27	26	risk	risk	NOUN
dpc-571	27	27	families	family	NOUN
dpc-571	27	28	,	,	PUNCT
dpc-571	27	29	depending	depend	VERB
dpc-571	27	30	on	on	ADP
dpc-571	27	31	selection	selection	NOUN
dpc-571	27	32	criteria	criterion	NOUN
dpc-571	27	33	and	and	CCONJ
dpc-571	27	34	on	on	ADP
dpc-571	27	35	geographic	geographic	ADJ
dpc-571	27	36	region	region	NOUN
dpc-571	27	37	of	of	ADP
dpc-571	27	38	the	the	DET
dpc-571	27	39	families	family	NOUN
dpc-571	27	40	[	[	X
dpc-571	27	41	12,13,27	12,13,27	NUM
dpc-571	27	42	-	-	SYM
dpc-571	27	43	32	32	NUM
dpc-571	27	44	]	]	PUNCT
dpc-571	27	45	.	.	PUNCT
dpc-571	28	1	the	the	DET
dpc-571	28	2	cdkn2a	cdkn2a	PROPN
dpc-571	28	3	tumor	tumor	NOUN
dpc-571	28	4	suppressor	suppressor	NOUN
dpc-571	28	5	gene	gene	NOUN
dpc-571	28	6	is	be	AUX
dpc-571	28	7	located	locate	VERB
dpc-571	28	8	at	at	ADP
dpc-571	28	9	the	the	DET
dpc-571	28	10	9p21	9p21	NOUN
dpc-571	28	11	locus	locus	NOUN
dpc-571	28	12	and	and	CCONJ
dpc-571	28	13	encodes	encodes	DET
dpc-571	28	14	2	2	NUM
dpc-571	28	15	different	different	ADJ
dpc-571	28	16	proteins	protein	NOUN
dpc-571	28	17	,	,	PUNCT
dpc-571	28	18	p16ink4a	p16ink4a	PROPN
dpc-571	28	19	(	(	PUNCT
dpc-571	28	20	p16	p16	PROPN
dpc-571	28	21	)	)	PUNCT
dpc-571	28	22	and	and	CCONJ
dpc-571	28	23	p14arf	p14arf	PROPN
dpc-571	28	24	(	(	PUNCT
dpc-571	28	25	p14	p14	PROPN
dpc-571	28	26	)	)	PUNCT
dpc-571	28	27	,	,	PUNCT
dpc-571	28	28	both	both	PRON
dpc-571	28	29	regulating	regulate	VERB
dpc-571	28	30	cell	cell	NOUN
dpc-571	28	31	cycle	cycle	NOUN
dpc-571	28	32	(	(	PUNCT
dpc-571	28	33	figure	figure	NOUN
dpc-571	28	34	1a	1a	NOUN
dpc-571	28	35	)	)	PUNCT
dpc-571	28	36	.	.	PUNCT
dpc-571	29	1	the	the	DET
dpc-571	29	2	p16	p16	NOUN
dpc-571	29	3	promotes	promote	VERB
dpc-571	29	4	cell	cell	NOUN
dpc-571	29	5	cycle	cycle	NOUN
dpc-571	29	6	arrest	arrest	NOUN
dpc-571	29	7	in	in	ADP
dpc-571	29	8	the	the	DET
dpc-571	29	9	g1	g1	PROPN
dpc-571	29	10	phase	phase	NOUN
dpc-571	29	11	by	by	ADP
dpc-571	29	12	inhibiting	inhibit	VERB
dpc-571	29	13	retinoblastoma	retinoblastoma	NOUN
dpc-571	29	14	(	(	PUNCT
dpc-571	29	15	rb	rb	NOUN
dpc-571	29	16	)	)	PUNCT
dpc-571	29	17	protein	protein	NOUN
dpc-571	29	18	phosphorylation	phosphorylation	NOUN
dpc-571	29	19	through	through	ADP
dpc-571	29	20	cyclindependent	cyclindependent	PROPN
dpc-571	29	21	kinase	kinase	PROPN
dpc-571	29	22	4	4	NUM
dpc-571	29	23	(	(	PUNCT
dpc-571	29	24	cdk4	cdk4	NOUN
dpc-571	29	25	)	)	PUNCT
dpc-571	29	26	.	.	PUNCT
dpc-571	30	1	p14	p14	PROPN
dpc-571	30	2	is	be	AUX
dpc-571	30	3	also	also	ADV
dpc-571	30	4	a	a	DET
dpc-571	30	5	tumor	tumor	NOUN
dpc-571	30	6	suppressor	suppressor	NOUN
dpc-571	30	7	and	and	CCONJ
dpc-571	30	8	acts	act	VERB
dpc-571	30	9	through	through	ADP
dpc-571	30	10	the	the	DET
dpc-571	30	11	p53	p53	NOUN
dpc-571	30	12	pathway	pathway	NOUN
dpc-571	30	13	inducing	induce	VERB
dpc-571	30	14	cell	cell	NOUN
dpc-571	30	15	cycle	cycle	NOUN
dpc-571	30	16	arrest	arrest	NOUN
dpc-571	30	17	or	or	CCONJ
dpc-571	30	18	favoring	favor	VERB
dpc-571	30	19	apoptosis	apoptosis	NOUN
dpc-571	30	20	[	[	X
dpc-571	30	21	33	33	NUM
dpc-571	30	22	]	]	PUNCT
dpc-571	30	23	.	.	PUNCT
dpc-571	31	1	the	the	DET
dpc-571	31	2	cdkn2a	cdkn2a	PROPN
dpc-571	31	3	gene	gene	NOUN
dpc-571	31	4	is	be	AUX
dpc-571	31	5	the	the	DET
dpc-571	31	6	major	major	ADJ
dpc-571	31	7	melanoma	melanoma	NOUN
dpc-571	31	8	susceptibility	susceptibility	NOUN
dpc-571	31	9	gene	gene	NOUN
dpc-571	31	10	with	with	ADP
dpc-571	31	11	more	more	ADJ
dpc-571	31	12	than	than	ADP
dpc-571	31	13	60	60	NUM
dpc-571	31	14	germline	germline	NOUN
dpc-571	31	15	mutations	mutation	NOUN
dpc-571	31	16	identified	identify	VERB
dpc-571	31	17	to	to	ADP
dpc-571	31	18	date	date	NOUN
dpc-571	31	19	,	,	PUNCT
dpc-571	31	20	the	the	DET
dpc-571	31	21	majority	majority	NOUN
dpc-571	31	22	of	of	ADP
dpc-571	31	23	which	which	PRON
dpc-571	31	24	are	be	AUX
dpc-571	31	25	missense	missense	NOUN
dpc-571	31	26	mutations	mutation	NOUN
dpc-571	31	27	in	in	ADP
dpc-571	31	28	the	the	DET
dpc-571	31	29	p16	p16	NOUN
dpc-571	31	30	transcript	transcript	NOUN
dpc-571	31	31	[	[	X
dpc-571	31	32	6,34	6,34	X
dpc-571	31	33	]	]	X
dpc-571	31	34	.	.	PUNCT
dpc-571	32	1	cdkn2a	cdkn2a	PROPN
dpc-571	32	2	mutation	mutation	NOUN
dpc-571	32	3	penetrance	penetrance	NOUN
dpc-571	32	4	varies	vary	VERB
dpc-571	32	5	introduction	introduction	NOUN
dpc-571	32	6	cutaneous	cutaneous	ADJ
dpc-571	32	7	melanoma	melanoma	NOUN
dpc-571	32	8	is	be	AUX
dpc-571	32	9	one	one	NUM
dpc-571	32	10	of	of	ADP
dpc-571	32	11	the	the	DET
dpc-571	32	12	most	most	ADV
dpc-571	32	13	aggressive	aggressive	ADJ
dpc-571	32	14	human	human	ADJ
dpc-571	32	15	cancers	cancer	NOUN
dpc-571	32	16	,	,	PUNCT
dpc-571	32	17	with	with	ADP
dpc-571	32	18	an	an	DET
dpc-571	32	19	increasing	increase	VERB
dpc-571	32	20	incidence	incidence	NOUN
dpc-571	32	21	worldwide	worldwide	ADV
dpc-571	33	1	[	[	X
dpc-571	33	2	1	1	NUM
dpc-571	33	3	]	]	PUNCT
dpc-571	33	4	.	.	PUNCT
dpc-571	34	1	when	when	SCONJ
dpc-571	34	2	detected	detect	VERB
dpc-571	34	3	at	at	ADP
dpc-571	34	4	an	an	DET
dpc-571	34	5	early	early	ADJ
dpc-571	34	6	stage	stage	NOUN
dpc-571	34	7	,	,	PUNCT
dpc-571	34	8	high	high	ADJ
dpc-571	34	9	survival	survival	NOUN
dpc-571	34	10	rates	rate	NOUN
dpc-571	34	11	are	be	AUX
dpc-571	34	12	reported	report	VERB
dpc-571	34	13	5	5	NUM
dpc-571	34	14	years	year	NOUN
dpc-571	34	15	after	after	ADP
dpc-571	34	16	diagnosis	diagnosis	NOUN
dpc-571	34	17	[	[	X
dpc-571	34	18	2	2	NUM
dpc-571	34	19	]	]	PUNCT
dpc-571	34	20	.	.	PUNCT
dpc-571	35	1	although	although	SCONJ
dpc-571	35	2	new	new	ADJ
dpc-571	35	3	therapies	therapy	NOUN
dpc-571	35	4	are	be	AUX
dpc-571	35	5	currently	currently	ADV
dpc-571	35	6	available	available	ADJ
dpc-571	35	7	for	for	ADP
dpc-571	35	8	metastatic	metastatic	ADJ
dpc-571	35	9	disease	disease	NOUN
dpc-571	35	10	,	,	PUNCT
dpc-571	35	11	survival	survival	NOUN
dpc-571	35	12	for	for	ADP
dpc-571	35	13	patients	patient	NOUN
dpc-571	35	14	with	with	ADP
dpc-571	35	15	advanced	advanced	ADJ
dpc-571	35	16	disease	disease	NOUN
dpc-571	35	17	is	be	AUX
dpc-571	35	18	still	still	ADV
dpc-571	35	19	poor	poor	ADJ
dpc-571	35	20	.	.	PUNCT
dpc-571	36	1	melanoma	melanoma	NOUN
dpc-571	36	2	pathogenesis	pathogenesis	NOUN
dpc-571	36	3	is	be	AUX
dpc-571	36	4	complex	complex	ADJ
dpc-571	36	5	and	and	CCONJ
dpc-571	36	6	heterogeneous	heterogeneous	ADJ
dpc-571	36	7	,	,	PUNCT
dpc-571	36	8	with	with	ADP
dpc-571	36	9	environmental	environmental	ADJ
dpc-571	36	10	,	,	PUNCT
dpc-571	36	11	phenotypic	phenotypic	NOUN
dpc-571	36	12	,	,	PUNCT
dpc-571	36	13	and	and	CCONJ
dpc-571	36	14	genetic	genetic	ADJ
dpc-571	36	15	factors	factor	NOUN
dpc-571	36	16	contributing	contribute	VERB
dpc-571	36	17	to	to	ADP
dpc-571	36	18	its	its	PRON
dpc-571	36	19	development	development	NOUN
dpc-571	36	20	.	.	PUNCT
dpc-571	37	1	the	the	DET
dpc-571	37	2	main	main	ADJ
dpc-571	37	3	risk	risk	NOUN
dpc-571	37	4	factors	factor	NOUN
dpc-571	37	5	involved	involve	VERB
dpc-571	37	6	in	in	ADP
dpc-571	37	7	the	the	DET
dpc-571	37	8	etiopathogenesis	etiopathogenesis	NOUN
dpc-571	37	9	of	of	ADP
dpc-571	37	10	cutaneous	cutaneous	ADJ
dpc-571	37	11	melanoma	melanoma	NOUN
dpc-571	37	12	are	be	AUX
dpc-571	37	13	a	a	DET
dpc-571	37	14	large	large	ADJ
dpc-571	37	15	number	number	NOUN
dpc-571	37	16	of	of	ADP
dpc-571	37	17	common	common	ADJ
dpc-571	37	18	acquired	acquire	VERB
dpc-571	37	19	melanocytic	melanocytic	ADJ
dpc-571	37	20	nevi	nevi	ADJ
dpc-571	37	21	,	,	PUNCT
dpc-571	37	22	atypical	atypical	ADJ
dpc-571	37	23	melanocytic	melanocytic	ADJ
dpc-571	37	24	nevi	nevi	NOUN
dpc-571	37	25	,	,	PUNCT
dpc-571	37	26	light	light	ADJ
dpc-571	37	27	skin	skin	NOUN
dpc-571	37	28	phenotype	phenotype	NOUN
dpc-571	37	29	,	,	PUNCT
dpc-571	37	30	exposure	exposure	NOUN
dpc-571	37	31	to	to	ADP
dpc-571	37	32	ultraviolet	ultraviolet	NOUN
dpc-571	37	33	(	(	PUNCT
dpc-571	37	34	uv	uv	NOUN
dpc-571	37	35	)	)	PUNCT
dpc-571	37	36	radiation	radiation	NOUN
dpc-571	37	37	,	,	PUNCT
dpc-571	37	38	and	and	CCONJ
dpc-571	37	39	a	a	DET
dpc-571	37	40	family	family	NOUN
dpc-571	37	41	history	history	NOUN
dpc-571	37	42	of	of	ADP
dpc-571	37	43	melanoma	melanoma	NOUN
dpc-571	37	44	[	[	X
dpc-571	37	45	3	3	NUM
dpc-571	37	46	-	-	SYM
dpc-571	37	47	5	5	NUM
dpc-571	37	48	]	]	PUNCT
dpc-571	37	49	.	.	PUNCT
dpc-571	38	1	an	an	DET
dpc-571	38	2	estimated	estimate	VERB
dpc-571	38	3	5%-10	5%-10	NUM
dpc-571	38	4	%	%	NOUN
dpc-571	38	5	of	of	ADP
dpc-571	38	6	all	all	DET
dpc-571	38	7	cutaneous	cutaneous	ADJ
dpc-571	38	8	melanoma	melanoma	NOUN
dpc-571	38	9	cases	case	NOUN
dpc-571	38	10	occur	occur	VERB
dpc-571	38	11	in	in	ADP
dpc-571	38	12	families	family	NOUN
dpc-571	38	13	.	.	PUNCT
dpc-571	39	1	familial	familial	ADJ
dpc-571	39	2	melanoma	melanoma	NOUN
dpc-571	39	3	is	be	AUX
dpc-571	39	4	defined	define	VERB
dpc-571	39	5	as	as	ADP
dpc-571	39	6	a	a	DET
dpc-571	39	7	family	family	NOUN
dpc-571	39	8	in	in	ADP
dpc-571	39	9	which	which	PRON
dpc-571	39	10	either	either	CCONJ
dpc-571	39	11	2	2	NUM
dpc-571	39	12	first	first	ADJ
dpc-571	39	13	-	-	PUNCT
dpc-571	39	14	degree	degree	NOUN
dpc-571	39	15	relatives	relative	NOUN
dpc-571	39	16	or	or	CCONJ
dpc-571	39	17	3	3	NUM
dpc-571	39	18	or	or	CCONJ
dpc-571	39	19	more	more	ADJ
dpc-571	39	20	melanoma	melanoma	NOUN
dpc-571	39	21	patients	patient	NOUN
dpc-571	39	22	on	on	ADP
dpc-571	39	23	the	the	DET
dpc-571	39	24	same	same	ADJ
dpc-571	39	25	side	side	NOUN
dpc-571	39	26	of	of	ADP
dpc-571	39	27	the	the	DET
dpc-571	39	28	family	family	NOUN
dpc-571	39	29	(	(	PUNCT
dpc-571	39	30	irrespective	irrespective	ADV
dpc-571	39	31	of	of	ADP
dpc-571	39	32	degree	degree	NOUN
dpc-571	39	33	of	of	ADP
dpc-571	39	34	relationship	relationship	NOUN
dpc-571	39	35	)	)	PUNCT
dpc-571	39	36	are	be	AUX
dpc-571	39	37	diagnosed	diagnose	VERB
dpc-571	39	38	with	with	ADP
dpc-571	39	39	melanoma	melanoma	NOUN
dpc-571	40	1	[	[	X
dpc-571	40	2	5	5	NUM
dpc-571	40	3	]	]	PUNCT
dpc-571	40	4	.	.	PUNCT
dpc-571	41	1	in	in	ADP
dpc-571	41	2	these	these	DET
dpc-571	41	3	families	family	NOUN
dpc-571	41	4	the	the	DET
dpc-571	41	5	pattern	pattern	NOUN
dpc-571	41	6	of	of	ADP
dpc-571	41	7	heritability	heritability	NOUN
dpc-571	41	8	is	be	AUX
dpc-571	41	9	consistent	consistent	ADJ
dpc-571	41	10	with	with	ADP
dpc-571	41	11	an	an	DET
dpc-571	41	12	autosomal	autosomal	ADJ
dpc-571	41	13	dominant	dominant	ADJ
dpc-571	41	14	inheritance	inheritance	NOUN
dpc-571	41	15	with	with	ADP
dpc-571	41	16	incomplete	incomplete	ADJ
dpc-571	41	17	penetrance	penetrance	NOUN
dpc-571	41	18	.	.	PUNCT
dpc-571	42	1	germline	germline	NOUN
dpc-571	42	2	susceptibility	susceptibility	NOUN
dpc-571	42	3	has	have	AUX
dpc-571	42	4	been	be	AUX
dpc-571	42	5	associated	associate	VERB
dpc-571	42	6	with	with	ADP
dpc-571	42	7	mutations	mutation	NOUN
dpc-571	42	8	in	in	ADP
dpc-571	42	9	high	high	ADJ
dpc-571	42	10	-	-	PUNCT
dpc-571	42	11	penetrance	penetrance	NOUN
dpc-571	42	12	melanoma	melanoma	NOUN
dpc-571	42	13	predisposition	predisposition	NOUN
dpc-571	42	14	genes	gene	NOUN
dpc-571	42	15	,	,	PUNCT
dpc-571	42	16	cdkn2a	cdkn2a	PROPN
dpc-571	42	17	(	(	PUNCT
dpc-571	42	18	cyclin	cyclin	NOUN
dpc-571	42	19	-	-	PUNCT
dpc-571	42	20	dependent	dependent	ADJ
dpc-571	42	21	kinase	kinase	NOUN
dpc-571	42	22	2a	2a	NUM
dpc-571	42	23	)	)	PUNCT
dpc-571	42	24	and	and	CCONJ
dpc-571	42	25	less	less	ADV
dpc-571	42	26	frequently	frequently	ADV
dpc-571	42	27	in	in	ADP
dpc-571	42	28	cdk4	cdk4	PROPN
dpc-571	42	29	(	(	PUNCT
dpc-571	42	30	cyclin	cyclin	NOUN
dpc-571	42	31	-	-	PUNCT
dpc-571	42	32	dependent	dependent	ADJ
dpc-571	42	33	kinase	kinase	NOUN
dpc-571	42	34	4	4	NUM
dpc-571	42	35	)	)	PUNCT
dpc-571	42	36	,	,	PUNCT
dpc-571	42	37	bap1	bap1	PROPN
dpc-571	42	38	(	(	PUNCT
dpc-571	42	39	breast	breast	NOUN
dpc-571	42	40	cancer	cancer	NOUN
dpc-571	42	41	associated	associate	VERB
dpc-571	42	42	protein-1	protein-1	PROPN
dpc-571	42	43	)	)	PUNCT
dpc-571	42	44	,	,	PUNCT
dpc-571	42	45	tert	tert	NOUN
dpc-571	42	46	(	(	PUNCT
dpc-571	42	47	telomerase	telomerase	NOUN
dpc-571	42	48	reverse	reverse	NOUN
dpc-571	42	49	transcriptase	transcriptase	NOUN
dpc-571	42	50	)	)	PUNCT
dpc-571	42	51	,	,	PUNCT
dpc-571	42	52	and	and	CCONJ
dpc-571	42	53	pot1	pot1	PROPN
dpc-571	42	54	(	(	PUNCT
dpc-571	42	55	protection	protection	NOUN
dpc-571	42	56	of	of	ADP
dpc-571	42	57	telomeres	telomere	NOUN
dpc-571	42	58	1	1	NUM
dpc-571	42	59	)	)	PUNCT
dpc-571	42	60	,	,	PUNCT
dpc-571	42	61	or	or	CCONJ
dpc-571	42	62	with	with	ADP
dpc-571	42	63	variants	variant	NOUN
dpc-571	42	64	in	in	ADP
dpc-571	42	65	intermediate	intermediate	ADJ
dpc-571	42	66	-	-	PUNCT
dpc-571	42	67	risk	risk	NOUN
dpc-571	42	68	genes	gene	NOUN
dpc-571	42	69	,	,	PUNCT
dpc-571	42	70	mc1r	mc1r	PROPN
dpc-571	42	71	(	(	PUNCT
dpc-571	42	72	melanocortin	melanocortin	NOUN
dpc-571	42	73	1	1	NUM
dpc-571	42	74	receptor	receptor	NOUN
dpc-571	42	75	)	)	PUNCT
dpc-571	42	76	and	and	CCONJ
dpc-571	42	77	mitf	mitf	NOUN
dpc-571	42	78	(	(	PUNCT
dpc-571	42	79	microphthalmia	microphthalmia	NOUN
dpc-571	42	80	-	-	PUNCT
dpc-571	42	81	associated	associate	VERB
dpc-571	42	82	transcription	transcription	NOUN
dpc-571	42	83	factor	factor	NOUN
dpc-571	42	84	)	)	PUNCT
dpc-571	43	1	[	[	X
dpc-571	43	2	6	6	NUM
dpc-571	43	3	-	-	SYM
dpc-571	43	4	9	9	NUM
dpc-571	43	5	]	]	PUNCT
dpc-571	43	6	.	.	PUNCT
dpc-571	44	1	currently	currently	ADV
dpc-571	44	2	,	,	PUNCT
dpc-571	44	3	genetic	genetic	ADJ
dpc-571	44	4	testing	testing	NOUN
dpc-571	44	5	is	be	AUX
dpc-571	44	6	recommended	recommend	VERB
dpc-571	44	7	in	in	ADP
dpc-571	44	8	high	high	ADJ
dpc-571	44	9	-	-	PUNCT
dpc-571	44	10	risk	risk	NOUN
dpc-571	44	11	melanoma	melanoma	NOUN
dpc-571	44	12	patients	patient	NOUN
dpc-571	44	13	and	and	CCONJ
dpc-571	44	14	families	family	NOUN
dpc-571	44	15	to	to	PART
dpc-571	44	16	improve	improve	VERB
dpc-571	44	17	early	early	ADJ
dpc-571	44	18	detection	detection	NOUN
dpc-571	44	19	and	and	CCONJ
dpc-571	44	20	reduce	reduce	VERB
dpc-571	44	21	mortality	mortality	NOUN
dpc-571	44	22	.	.	PUNCT
dpc-571	45	1	individuals	individual	NOUN
dpc-571	45	2	from	from	ADP
dpc-571	45	3	high	high	ADJ
dpc-571	45	4	-	-	PUNCT
dpc-571	45	5	risk	risk	NOUN
dpc-571	45	6	melanoma	melanoma	NOUN
dpc-571	45	7	families	family	NOUN
dpc-571	45	8	must	must	AUX
dpc-571	45	9	receive	receive	VERB
dpc-571	45	10	genetic	genetic	ADJ
dpc-571	45	11	counseling	counseling	NOUN
dpc-571	45	12	so	so	SCONJ
dpc-571	45	13	that	that	SCONJ
dpc-571	45	14	they	they	PRON
dpc-571	45	15	receive	receive	VERB
dpc-571	45	16	full	full	ADJ
dpc-571	45	17	information	information	NOUN
dpc-571	45	18	about	about	ADP
dpc-571	45	19	the	the	DET
dpc-571	45	20	inclusion	inclusion	NOUN
dpc-571	45	21	criteria	criterion	NOUN
dpc-571	45	22	for	for	ADP
dpc-571	45	23	genetic	genetic	ADJ
dpc-571	45	24	testtable	testtable	NOUN
dpc-571	45	25	1	1	NUM
dpc-571	45	26	.	.	PUNCT
dpc-571	45	27	overview	overview	NOUN
dpc-571	45	28	of	of	ADP
dpc-571	45	29	highand	highand	ADJ
dpc-571	45	30	intermediate	intermediate	ADJ
dpc-571	45	31	-	-	PUNCT
dpc-571	45	32	penetrance	penetrance	NOUN
dpc-571	45	33	genes	gene	NOUN
dpc-571	45	34	involved	involve	VERB
dpc-571	45	35	in	in	ADP
dpc-571	45	36	melanoma	melanoma	NOUN
dpc-571	45	37	susceptibility	susceptibility	NOUN
dpc-571	45	38	gene	gene	NOUN
dpc-571	45	39	penetrance	penetrance	NOUN
dpc-571	45	40	gene	gene	NOUN
dpc-571	45	41	encoded	encode	VERB
dpc-571	45	42	protein	protein	NOUN
dpc-571	45	43	role	role	NOUN
dpc-571	45	44	mutation	mutation	NOUN
dpc-571	45	45	prevalence	prevalence	NOUN
dpc-571	45	46	references	reference	VERB
dpc-571	45	47	high	high	ADJ
dpc-571	45	48	-	-	PUNCT
dpc-571	45	49	penetrance	penetrance	NOUN
dpc-571	45	50	cdkn2a	cdkn2a	PROPN
dpc-571	45	51	p16ink4a	p16ink4a	NOUN
dpc-571	45	52	cell	cell	NOUN
dpc-571	45	53	cycle	cycle	NOUN
dpc-571	45	54	regulator	regulator	NOUN
dpc-571	45	55	~20%-40	~20%-40	NOUN
dpc-571	45	56	%	%	NOUN
dpc-571	45	57	of	of	ADP
dpc-571	45	58	families	family	NOUN
dpc-571	45	59	10	10	NUM
dpc-571	45	60	-	-	SYM
dpc-571	45	61	13	13	NUM
dpc-571	45	62	p14arf	p14arf	NOUN
dpc-571	45	63	cell	cell	NOUN
dpc-571	45	64	cycle	cycle	NOUN
dpc-571	45	65	regulator	regulator	NOUN
dpc-571	45	66	~1	~1	VERB
dpc-571	45	67	%	%	NOUN
dpc-571	45	68	of	of	ADP
dpc-571	45	69	families	family	NOUN
dpc-571	45	70	9,14,15	9,14,15	NUM
dpc-571	45	71	cdk4	cdk4	NOUN
dpc-571	45	72	cdk4	cdk4	NOUN
dpc-571	45	73	cell	cell	NOUN
dpc-571	45	74	cycle	cycle	NOUN
dpc-571	45	75	regulator	regulator	NOUN
dpc-571	45	76	17	17	NUM
dpc-571	45	77	families	family	NOUN
dpc-571	45	78	16,17	16,17	NUM
dpc-571	45	79	tert	tert	NOUN
dpc-571	45	80	catalytic	catalytic	ADJ
dpc-571	45	81	subunit	subunit	NOUN
dpc-571	45	82	of	of	ADP
dpc-571	45	83	telomerase	telomerase	NOUN
dpc-571	45	84	telomere	telomere	NOUN
dpc-571	45	85	elongation	elongation	NOUN
dpc-571	45	86	2	2	NUM
dpc-571	45	87	families	family	NOUN
dpc-571	45	88	18,19	18,19	PROPN
dpc-571	45	89	pot1	pot1	PROPN
dpc-571	45	90	pot1	pot1	PROPN
dpc-571	45	91	telomere	telomere	PROPN
dpc-571	45	92	maintenance	maintenance	VERB
dpc-571	45	93	14	14	NUM
dpc-571	45	94	families	family	NOUN
dpc-571	45	95	20	20	NUM
dpc-571	45	96	-	-	SYM
dpc-571	45	97	22	22	NUM
dpc-571	45	98	intermediatepenetrance	intermediatepenetrance	NOUN
dpc-571	45	99	mc1r	mc1r	PROPN
dpc-571	45	100	mc1r	mc1r	PROPN
dpc-571	45	101	melanin	melanin	ADJ
dpc-571	45	102	synthesis	synthesis	NOUN
dpc-571	45	103	and	and	CCONJ
dpc-571	45	104	melanocyte	melanocyte	NOUN
dpc-571	45	105	proliferation	proliferation	NOUN
dpc-571	45	106	na	na	NOUN
dpc-571	45	107	23,24	23,24	NUM
dpc-571	45	108	mitf	mitf	ADJ
dpc-571	45	109	mitf	mitf	PROPN
dpc-571	45	110	melanocyte	melanocyte	PROPN
dpc-571	45	111	development	development	NOUN
dpc-571	45	112	and	and	CCONJ
dpc-571	45	113	differentiation	differentiation	NOUN
dpc-571	45	114	na	na	ADP
dpc-571	45	115	25,26	25,26	NUM
dpc-571	45	116	cdk4	cdk4	NOUN
dpc-571	45	117	=	=	PUNCT
dpc-571	45	118	cyclin	cyclin	NOUN
dpc-571	45	119	-	-	PUNCT
dpc-571	45	120	dependent	dependent	ADJ
dpc-571	45	121	kinase	kinase	NOUN
dpc-571	45	122	4	4	NUM
dpc-571	45	123	;	;	PUNCT
dpc-571	46	1	cdkn2a	cdkn2a	PROPN
dpc-571	46	2	=	=	SYM
dpc-571	46	3	cyclin	cyclin	NOUN
dpc-571	46	4	-	-	PUNCT
dpc-571	46	5	dependent	dependent	ADJ
dpc-571	46	6	kinase	kinase	PROPN
dpc-571	46	7	2a	2a	NUM
dpc-571	46	8	;	;	PUNCT
dpc-571	46	9	mc1r	mc1r	PROPN
dpc-571	46	10	=	=	SYM
dpc-571	46	11	melanocortin	melanocortin	NOUN
dpc-571	46	12	1	1	NUM
dpc-571	46	13	receptor	receptor	NOUN
dpc-571	46	14	;	;	PUNCT
dpc-571	46	15	mitf	mitf	NOUN
dpc-571	46	16	=	=	SYM
dpc-571	46	17	microphthalmia	microphthalmia	NOUN
dpc-571	46	18	associated	associate	VERB
dpc-571	46	19	transcription	transcription	NOUN
dpc-571	46	20	factor	factor	NOUN
dpc-571	46	21	;	;	PUNCT
dpc-571	46	22	na	na	ADP
dpc-571	46	23	=	=	PUNCT
dpc-571	46	24	not	not	PART
dpc-571	46	25	applicable	applicable	ADJ
dpc-571	46	26	;	;	PUNCT
dpc-571	46	27	pot1	pot1	PROPN
dpc-571	46	28	=	=	SYM
dpc-571	46	29	protec	protec	ADJ
dpc-571	46	30	tion	tion	NOUN
dpc-571	46	31	of	of	ADP
dpc-571	46	32	telomeres	telomere	NOUN
dpc-571	46	33	1	1	NUM
dpc-571	46	34	;	;	PUNCT
dpc-571	46	35	tert	tert	NOUN
dpc-571	46	36	=	=	SYM
dpc-571	46	37	telomerase	telomerase	NOUN
dpc-571	46	38	reverse	reverse	NOUN
dpc-571	46	39	transcriptase	transcriptase	NOUN
dpc-571	46	40	.	.	PUNCT
dpc-571	47	1	12	12	NUM
dpc-571	47	2	review	review	NOUN
dpc-571	47	3	|	|	ADV
dpc-571	47	4	dermatol	dermatol	ADJ
dpc-571	47	5	pract	pract	NOUN
dpc-571	47	6	concept	concept	NOUN
dpc-571	47	7	2019;9(1):3	2019;9(1):3	NUM
dpc-571	47	8	between	between	ADP
dpc-571	47	9	geographical	geographical	ADJ
dpc-571	47	10	areas	area	NOUN
dpc-571	47	11	,	,	PUNCT
dpc-571	47	12	according	accord	VERB
dpc-571	47	13	to	to	ADP
dpc-571	47	14	the	the	DET
dpc-571	47	15	population	population	NOUN
dpc-571	47	16	incidence	incidence	NOUN
dpc-571	47	17	rate	rate	NOUN
dpc-571	47	18	of	of	ADP
dpc-571	47	19	melanoma	melanoma	NOUN
dpc-571	47	20	,	,	PUNCT
dpc-571	47	21	ranging	range	VERB
dpc-571	47	22	from	from	ADP
dpc-571	47	23	58	58	NUM
dpc-571	47	24	%	%	NOUN
dpc-571	47	25	in	in	ADP
dpc-571	47	26	europe	europe	PROPN
dpc-571	47	27	to	to	ADP
dpc-571	47	28	76	76	NUM
dpc-571	47	29	%	%	NOUN
dpc-571	47	30	in	in	ADP
dpc-571	47	31	the	the	DET
dpc-571	47	32	united	united	PROPN
dpc-571	47	33	states	states	PROPN
dpc-571	47	34	and	and	CCONJ
dpc-571	47	35	to	to	ADP
dpc-571	47	36	91	91	NUM
dpc-571	47	37	%	%	NOUN
dpc-571	47	38	in	in	ADP
dpc-571	47	39	australia	australia	PROPN
dpc-571	47	40	by	by	ADP
dpc-571	47	41	age	age	NOUN
dpc-571	47	42	80	80	NUM
dpc-571	47	43	years	year	NOUN
dpc-571	47	44	[	[	X
dpc-571	47	45	35	35	NUM
dpc-571	47	46	]	]	PUNCT
dpc-571	47	47	.	.	PUNCT
dpc-571	48	1	the	the	DET
dpc-571	48	2	likelihood	likelihood	NOUN
dpc-571	48	3	of	of	ADP
dpc-571	48	4	detecting	detect	VERB
dpc-571	48	5	a	a	DET
dpc-571	48	6	cdkn2a	cdkn2a	ADJ
dpc-571	48	7	mutation	mutation	NOUN
dpc-571	48	8	in	in	ADP
dpc-571	48	9	melanoma	melanoma	NOUN
dpc-571	48	10	families	family	NOUN
dpc-571	48	11	increases	increase	VERB
dpc-571	48	12	with	with	ADP
dpc-571	48	13	the	the	DET
dpc-571	48	14	number	number	NOUN
dpc-571	48	15	of	of	ADP
dpc-571	48	16	affected	affected	ADJ
dpc-571	48	17	members	member	NOUN
dpc-571	48	18	(	(	PUNCT
dpc-571	48	19	approximately	approximately	ADV
dpc-571	48	20	10	10	NUM
dpc-571	48	21	%	%	NOUN
dpc-571	48	22	for	for	ADP
dpc-571	48	23	2	2	NUM
dpc-571	48	24	-	-	PUNCT
dpc-571	48	25	case	case	NOUN
dpc-571	48	26	melanoma	melanoma	NOUN
dpc-571	48	27	families	family	NOUN
dpc-571	48	28	and	and	CCONJ
dpc-571	48	29	30%40	30%40	NUM
dpc-571	48	30	%	%	NOUN
dpc-571	48	31	for	for	ADP
dpc-571	48	32	families	family	NOUN
dpc-571	48	33	with	with	ADP
dpc-571	48	34	3	3	NUM
dpc-571	48	35	or	or	CCONJ
dpc-571	48	36	more	more	ADJ
dpc-571	48	37	cases	case	NOUN
dpc-571	48	38	of	of	ADP
dpc-571	48	39	melanoma	melanoma	NOUN
dpc-571	48	40	)	)	PUNCT
dpc-571	48	41	,	,	PUNCT
dpc-571	48	42	with	with	SCONJ
dpc-571	48	43	the	the	DET
dpc-571	48	44	presence	presence	NOUN
dpc-571	48	45	within	within	ADP
dpc-571	48	46	the	the	DET
dpc-571	48	47	family	family	NOUN
dpc-571	48	48	of	of	ADP
dpc-571	48	49	relatives	relative	NOUN
dpc-571	48	50	with	with	ADP
dpc-571	48	51	multiple	multiple	ADJ
dpc-571	48	52	primary	primary	ADJ
dpc-571	48	53	melanoma	melanoma	NOUN
dpc-571	48	54	(	(	PUNCT
dpc-571	48	55	mpm	mpm	NOUN
dpc-571	48	56	)	)	PUNCT
dpc-571	48	57	,	,	PUNCT
dpc-571	48	58	pancreatic	pancreatic	ADJ
dpc-571	48	59	cancer	cancer	NOUN
dpc-571	48	60	,	,	PUNCT
dpc-571	48	61	or	or	CCONJ
dpc-571	48	62	early	early	ADJ
dpc-571	48	63	age	age	NOUN
dpc-571	48	64	at	at	ADP
dpc-571	48	65	melanoma	melanoma	NOUN
dpc-571	48	66	onset	onset	NOUN
dpc-571	48	67	[	[	X
dpc-571	48	68	36	36	NUM
dpc-571	48	69	]	]	PUNCT
dpc-571	48	70	.	.	PUNCT
dpc-571	49	1	in	in	ADP
dpc-571	49	2	addition	addition	NOUN
dpc-571	49	3	,	,	PUNCT
dpc-571	49	4	cdkn2a	cdkn2a	PROPN
dpc-571	49	5	mutations	mutation	NOUN
dpc-571	49	6	are	be	AUX
dpc-571	49	7	also	also	ADV
dpc-571	49	8	detected	detect	VERB
dpc-571	49	9	in	in	ADP
dpc-571	49	10	individuals	individual	NOUN
dpc-571	49	11	with	with	ADP
dpc-571	49	12	mpm	mpm	NOUN
dpc-571	49	13	in	in	ADP
dpc-571	49	14	the	the	DET
dpc-571	49	15	absence	absence	NOUN
dpc-571	49	16	of	of	ADP
dpc-571	49	17	a	a	DET
dpc-571	49	18	family	family	NOUN
dpc-571	49	19	history	history	NOUN
dpc-571	49	20	of	of	ADP
dpc-571	49	21	melanoma	melanoma	NOUN
dpc-571	49	22	in	in	ADP
dpc-571	49	23	8.3	8.3	NUM
dpc-571	49	24	%	%	NOUN
dpc-571	49	25	,	,	PUNCT
dpc-571	49	26	15	15	NUM
dpc-571	49	27	%	%	NOUN
dpc-571	49	28	,	,	PUNCT
dpc-571	49	29	and	and	CCONJ
dpc-571	49	30	57	57	NUM
dpc-571	49	31	%	%	NOUN
dpc-571	49	32	in	in	ADP
dpc-571	49	33	united	united	PROPN
dpc-571	49	34	states	states	PROPN
dpc-571	49	35	,	,	PUNCT
dpc-571	49	36	north	north	PROPN
dpc-571	49	37	america	america	PROPN
dpc-571	49	38	,	,	PUNCT
dpc-571	49	39	and	and	CCONJ
dpc-571	49	40	greece	greece	PROPN
dpc-571	49	41	,	,	PUNCT
dpc-571	49	42	respectively	respectively	ADV
dpc-571	49	43	[	[	X
dpc-571	49	44	37,38	37,38	NOUN
dpc-571	49	45	]	]	PUNCT
dpc-571	49	46	.	.	PUNCT
dpc-571	50	1	the	the	DET
dpc-571	50	2	association	association	NOUN
dpc-571	50	3	between	between	ADP
dpc-571	50	4	pancreatic	pancreatic	ADJ
dpc-571	50	5	cancer	cancer	NOUN
dpc-571	50	6	and	and	CCONJ
dpc-571	50	7	melanoma	melanoma	NOUN
dpc-571	50	8	is	be	AUX
dpc-571	50	9	often	often	ADV
dpc-571	50	10	observed	observe	VERB
dpc-571	50	11	in	in	ADP
dpc-571	50	12	cdkn2a	cdkn2a	PROPN
dpc-571	50	13	-	-	PUNCT
dpc-571	50	14	mutated	mutate	VERB
dpc-571	50	15	melanoma	melanoma	NOUN
dpc-571	50	16	families	family	NOUN
dpc-571	50	17	figure	figure	VERB
dpc-571	50	18	1	1	NUM
dpc-571	50	19	.	.	PUNCT
dpc-571	51	1	pathways	pathway	NOUN
dpc-571	51	2	of	of	ADP
dpc-571	51	3	high	high	ADJ
dpc-571	51	4	-	-	PUNCT
dpc-571	51	5	risk	risk	NOUN
dpc-571	51	6	genes	gene	NOUN
dpc-571	51	7	involved	involve	VERB
dpc-571	51	8	in	in	ADP
dpc-571	51	9	melanoma	melanoma	NOUN
dpc-571	51	10	susceptibility	susceptibility	NOUN
dpc-571	51	11	.	.	PUNCT
dpc-571	52	1	(	(	PUNCT
dpc-571	52	2	a	a	X
dpc-571	52	3	)	)	PUNCT
dpc-571	52	4	cdkn2a	cdkn2a	PROPN
dpc-571	52	5	encodes	encode	NOUN
dpc-571	52	6	2	2	NUM
dpc-571	52	7	proteins	protein	NOUN
dpc-571	52	8	:	:	PUNCT
dpc-571	52	9	p16ink4a	p16ink4a	NOUN
dpc-571	52	10	and	and	CCONJ
dpc-571	52	11	p14arf	p14arf	PROPN
dpc-571	52	12	.	.	PUNCT
dpc-571	53	1	mutations	mutation	NOUN
dpc-571	53	2	in	in	ADP
dpc-571	53	3	cdkn2a	cdkn2a	PROPN
dpc-571	53	4	gene	gene	NOUN
dpc-571	53	5	allow	allow	VERB
dpc-571	53	6	the	the	DET
dpc-571	53	7	cells	cell	NOUN
dpc-571	53	8	to	to	PART
dpc-571	53	9	escape	escape	VERB
dpc-571	53	10	from	from	ADP
dpc-571	53	11	cell	cell	NOUN
dpc-571	53	12	cycle	cycle	NOUN
dpc-571	53	13	arrest	arrest	NOUN
dpc-571	53	14	.	.	PUNCT
dpc-571	54	1	in	in	ADP
dpc-571	54	2	detail	detail	NOUN
dpc-571	54	3	,	,	PUNCT
dpc-571	54	4	p16ink4a	p16ink4a	PROPN
dpc-571	54	5	inhibits	inhibit	VERB
dpc-571	54	6	cyclin	cyclin	NOUN
dpc-571	54	7	d1	d1	PROPN
dpc-571	54	8	/	/	SYM
dpc-571	54	9	cdk4/6	cdk4/6	NOUN
dpc-571	54	10	complex	complex	NOUN
dpc-571	54	11	to	to	PART
dpc-571	54	12	release	release	VERB
dpc-571	54	13	e2f	e2f	PROPN
dpc-571	54	14	through	through	ADP
dpc-571	54	15	rb	rb	NOUN
dpc-571	54	16	phosphorylation	phosphorylation	NOUN
dpc-571	54	17	.	.	PUNCT
dpc-571	55	1	p14arf	p14arf	PROPN
dpc-571	55	2	interacts	interact	VERB
dpc-571	55	3	with	with	ADP
dpc-571	55	4	mdm2	mdm2	PROPN
dpc-571	55	5	to	to	PART
dpc-571	55	6	block	block	VERB
dpc-571	55	7	p53	p53	NOUN
dpc-571	55	8	ubiquitination	ubiquitination	NOUN
dpc-571	55	9	,	,	PUNCT
dpc-571	55	10	thus	thus	ADV
dpc-571	55	11	promoting	promote	VERB
dpc-571	55	12	apoptosis	apoptosis	NOUN
dpc-571	55	13	.	.	PUNCT
dpc-571	56	1	when	when	SCONJ
dpc-571	56	2	mutated	mutate	VERB
dpc-571	56	3	,	,	PUNCT
dpc-571	56	4	cdkn2a	cdkn2a	PROPN
dpc-571	56	5	produces	produce	VERB
dpc-571	56	6	2	2	NUM
dpc-571	56	7	dysfunctional	dysfunctional	ADJ
dpc-571	56	8	proteins	protein	NOUN
dpc-571	56	9	inducing	induce	VERB
dpc-571	56	10	cell	cell	NOUN
dpc-571	56	11	cycle	cycle	NOUN
dpc-571	56	12	progression	progression	NOUN
dpc-571	56	13	and	and	CCONJ
dpc-571	56	14	avoiding	avoid	VERB
dpc-571	56	15	p53	p53	NOUN
dpc-571	56	16	degradation	degradation	NOUN
dpc-571	56	17	.	.	PUNCT
dpc-571	57	1	(	(	PUNCT
dpc-571	57	2	b	b	X
dpc-571	57	3	)	)	PUNCT
dpc-571	57	4	mutations	mutation	NOUN
dpc-571	57	5	in	in	ADP
dpc-571	57	6	cdk4	cdk4	NOUN
dpc-571	57	7	promote	promote	VERB
dpc-571	57	8	the	the	DET
dpc-571	57	9	g1	g1	NOUN
dpc-571	57	10	to	to	ADP
dpc-571	57	11	s	s	NOUN
dpc-571	57	12	phase	phase	NOUN
dpc-571	57	13	transition	transition	NOUN
dpc-571	57	14	,	,	PUNCT
dpc-571	57	15	escaping	escape	VERB
dpc-571	57	16	the	the	DET
dpc-571	57	17	p16ink4a	p16ink4a	NOUN
dpc-571	57	18	inhibition	inhibition	NOUN
dpc-571	57	19	.	.	PUNCT
dpc-571	58	1	(	(	PUNCT
dpc-571	58	2	c	c	X
dpc-571	58	3	)	)	PUNCT
dpc-571	58	4	tert	tert	NOUN
dpc-571	58	5	encodes	encode	VERB
dpc-571	58	6	the	the	DET
dpc-571	58	7	telomerase	telomerase	NOUN
dpc-571	58	8	reverse	reverse	NOUN
dpc-571	58	9	transcriptase	transcriptase	NOUN
dpc-571	58	10	,	,	PUNCT
dpc-571	58	11	involved	involve	VERB
dpc-571	58	12	in	in	ADP
dpc-571	58	13	the	the	DET
dpc-571	58	14	maintenance	maintenance	NOUN
dpc-571	58	15	of	of	ADP
dpc-571	58	16	telomere	telomere	NOUN
dpc-571	58	17	length	length	NOUN
dpc-571	58	18	.	.	PUNCT
dpc-571	59	1	mutations	mutation	NOUN
dpc-571	59	2	in	in	ADP
dpc-571	59	3	the	the	DET
dpc-571	59	4	promoter	promoter	NOUN
dpc-571	59	5	region	region	NOUN
dpc-571	59	6	of	of	ADP
dpc-571	59	7	tert	tert	NOUN
dpc-571	59	8	increase	increase	NOUN
dpc-571	59	9	telomerase	telomerase	NOUN
dpc-571	59	10	activity	activity	NOUN
dpc-571	59	11	resulting	result	VERB
dpc-571	59	12	in	in	ADP
dpc-571	59	13	chromosomal	chromosomal	ADJ
dpc-571	59	14	instability	instability	NOUN
dpc-571	59	15	.	.	PUNCT
dpc-571	60	1	pot1	pot1	PROPN
dpc-571	60	2	interacts	interact	VERB
dpc-571	60	3	with	with	ADP
dpc-571	60	4	the	the	DET
dpc-571	60	5	shelterin	shelterin	NOUN
dpc-571	60	6	complex	complex	NOUN
dpc-571	60	7	acting	act	VERB
dpc-571	60	8	as	as	ADP
dpc-571	60	9	protective	protective	ADJ
dpc-571	60	10	structure	structure	NOUN
dpc-571	60	11	which	which	PRON
dpc-571	60	12	prevents	prevent	VERB
dpc-571	60	13	access	access	NOUN
dpc-571	60	14	of	of	ADP
dpc-571	60	15	tert	tert	NOUN
dpc-571	60	16	to	to	ADP
dpc-571	60	17	telomeres	telomere	NOUN
dpc-571	60	18	.	.	PUNCT
dpc-571	61	1	the	the	DET
dpc-571	61	2	s270n	s270n	PROPN
dpc-571	61	3	mutation	mutation	NOUN
dpc-571	61	4	in	in	ADP
dpc-571	61	5	the	the	DET
dpc-571	61	6	pot1	pot1	PROPN
dpc-571	61	7	gene	gene	NOUN
dpc-571	61	8	has	have	AUX
dpc-571	61	9	been	be	AUX
dpc-571	61	10	associated	associate	VERB
dpc-571	61	11	with	with	ADP
dpc-571	61	12	familial	familial	ADJ
dpc-571	61	13	melanoma	melanoma	NOUN
dpc-571	61	14	.	.	PUNCT
dpc-571	62	1	cdk	cdk	NOUN
dpc-571	62	2	=	=	SYM
dpc-571	62	3	cyclin	cyclin	NOUN
dpc-571	62	4	-	-	PUNCT
dpc-571	62	5	dependent	dependent	ADJ
dpc-571	62	6	kinase	kinase	NOUN
dpc-571	62	7	;	;	PUNCT
dpc-571	62	8	cdkn2a	cdkn2a	PROPN
dpc-571	62	9	=	=	SYM
dpc-571	62	10	cyclin	cyclin	NOUN
dpc-571	62	11	-	-	PUNCT
dpc-571	62	12	dependent	dependent	ADJ
dpc-571	62	13	kinase	kinase	NOUN
dpc-571	62	14	inhibitor	inhibitor	PROPN
dpc-571	62	15	2a	2a	NUM
dpc-571	62	16	;	;	PUNCT
dpc-571	62	17	mdm2	mdm2	PROPN
dpc-571	62	18	=	=	SYM
dpc-571	62	19	mouse	mouse	PROPN
dpc-571	62	20	double	double	ADJ
dpc-571	62	21	minute	minute	NOUN
dpc-571	62	22	2	2	NUM
dpc-571	62	23	;	;	PUNCT
dpc-571	62	24	pot1	pot1	PROPN
dpc-571	62	25	=	=	PROPN
dpc-571	62	26	protection	protection	NOUN
dpc-571	62	27	of	of	ADP
dpc-571	62	28	telomeres	telomere	NOUN
dpc-571	62	29	1	1	NUM
dpc-571	62	30	;	;	PUNCT
dpc-571	62	31	rb	rb	X
dpc-571	62	32	=	=	NOUN
dpc-571	62	33	retinoblastoma	retinoblastoma	NOUN
dpc-571	62	34	.	.	PUNCT
dpc-571	63	1	[	[	X
dpc-571	63	2	copyright	copyright	NOUN
dpc-571	63	3	:	:	PUNCT
dpc-571	63	4	©	©	PROPN
dpc-571	63	5	2019	2019	NUM
dpc-571	63	6	rossi	rossi	ADJ
dpc-571	63	7	et	et	PROPN
dpc-571	63	8	 	 	SPACE
dpc-571	63	9	al	al	PROPN
dpc-571	63	10	.	.	PROPN
dpc-571	63	11	]	]	PUNCT
dpc-571	63	12	and	and	CCONJ
dpc-571	63	13	has	have	AUX
dpc-571	63	14	been	be	AUX
dpc-571	63	15	proposed	propose	VERB
dpc-571	63	16	as	as	ADP
dpc-571	63	17	a	a	DET
dpc-571	63	18	hereditary	hereditary	ADJ
dpc-571	63	19	cancer	cancer	NOUN
dpc-571	63	20	syndrome	syndrome	NOUN
dpc-571	63	21	[	[	X
dpc-571	63	22	39	39	NUM
dpc-571	63	23	-	-	SYM
dpc-571	63	24	45	45	NUM
dpc-571	63	25	]	]	PUNCT
dpc-571	63	26	.	.	PUNCT
dpc-571	64	1	annual	annual	ADJ
dpc-571	64	2	surveillance	surveillance	NOUN
dpc-571	64	3	for	for	ADP
dpc-571	64	4	pancreatic	pancreatic	ADJ
dpc-571	64	5	cancer	cancer	NOUN
dpc-571	64	6	is	be	AUX
dpc-571	64	7	therefore	therefore	ADV
dpc-571	64	8	warranted	warrant	VERB
dpc-571	64	9	in	in	ADP
dpc-571	64	10	high	high	ADJ
dpc-571	64	11	-	-	PUNCT
dpc-571	64	12	risk	risk	NOUN
dpc-571	64	13	melanoma	melanoma	NOUN
dpc-571	64	14	families	family	NOUN
dpc-571	64	15	with	with	ADP
dpc-571	64	16	cdkn2a	cdkn2a	PROPN
dpc-571	64	17	mutations	mutation	NOUN
dpc-571	64	18	[	[	X
dpc-571	64	19	46	46	NUM
dpc-571	64	20	]	]	PUNCT
dpc-571	64	21	.	.	PUNCT
dpc-571	65	1	besides	besides	SCONJ
dpc-571	65	2	pancreatic	pancreatic	ADJ
dpc-571	65	3	cancer	cancer	NOUN
dpc-571	65	4	,	,	PUNCT
dpc-571	65	5	families	family	NOUN
dpc-571	65	6	with	with	ADP
dpc-571	65	7	cdkn2a	cdkn2a	PROPN
dpc-571	65	8	mutations	mutation	NOUN
dpc-571	65	9	have	have	AUX
dpc-571	65	10	been	be	AUX
dpc-571	65	11	reported	report	VERB
dpc-571	65	12	to	to	PART
dpc-571	65	13	also	also	ADV
dpc-571	65	14	have	have	VERB
dpc-571	65	15	an	an	DET
dpc-571	65	16	increased	increase	VERB
dpc-571	65	17	risk	risk	NOUN
dpc-571	65	18	of	of	ADP
dpc-571	65	19	developing	develop	VERB
dpc-571	65	20	breast	breast	NOUN
dpc-571	65	21	,	,	PUNCT
dpc-571	65	22	lung	lung	NOUN
dpc-571	65	23	,	,	PUNCT
dpc-571	65	24	and	and	CCONJ
dpc-571	65	25	other	other	ADJ
dpc-571	65	26	tobacco	tobacco	NOUN
dpc-571	65	27	-	-	PUNCT
dpc-571	65	28	related	relate	VERB
dpc-571	65	29	cancers	cancer	NOUN
dpc-571	65	30	[	[	X
dpc-571	65	31	42	42	NUM
dpc-571	65	32	]	]	PUNCT
dpc-571	65	33	.	.	PUNCT
dpc-571	66	1	few	few	ADJ
dpc-571	66	2	melanoma	melanoma	NOUN
dpc-571	66	3	kindreds	kindred	NOUN
dpc-571	66	4	worldwide	worldwide	ADV
dpc-571	66	5	have	have	AUX
dpc-571	66	6	been	be	AUX
dpc-571	66	7	found	find	VERB
dpc-571	66	8	to	to	PART
dpc-571	66	9	carry	carry	VERB
dpc-571	66	10	mutations	mutation	NOUN
dpc-571	66	11	of	of	ADP
dpc-571	66	12	b	b	NOUN
dpc-571	66	13	a	a	DET
dpc-571	66	14	c	c	NOUN
dpc-571	66	15	review	review	NOUN
dpc-571	67	1	|	|	ADV
dpc-571	67	2	dermatol	dermatol	ADJ
dpc-571	67	3	pract	pract	NOUN
dpc-571	67	4	concept	concept	NOUN
dpc-571	67	5	2019;9(1):3	2019;9(1):3	PROPN
dpc-571	67	6	13	13	NUM
dpc-571	67	7	intermediate	intermediate	ADJ
dpc-571	67	8	-	-	PUNCT
dpc-571	67	9	penetrance	penetrance	NOUN
dpc-571	67	10	genes	gene	NOUN
dpc-571	67	11	in	in	ADP
dpc-571	67	12	almost	almost	ADV
dpc-571	67	13	half	half	NOUN
dpc-571	67	14	of	of	ADP
dpc-571	67	15	highly	highly	ADV
dpc-571	67	16	dense	dense	ADJ
dpc-571	67	17	melanoma	melanoma	NOUN
dpc-571	67	18	families	family	NOUN
dpc-571	67	19	,	,	PUNCT
dpc-571	67	20	the	the	DET
dpc-571	67	21	underlying	underlie	VERB
dpc-571	67	22	genetic	genetic	ADJ
dpc-571	67	23	basis	basis	NOUN
dpc-571	67	24	is	be	AUX
dpc-571	67	25	still	still	ADV
dpc-571	67	26	unexplained	unexplained	ADJ
dpc-571	67	27	.	.	PUNCT
dpc-571	68	1	besides	besides	SCONJ
dpc-571	68	2	the	the	DET
dpc-571	68	3	possibility	possibility	NOUN
dpc-571	68	4	of	of	ADP
dpc-571	68	5	rare	rare	ADJ
dpc-571	68	6	mutations	mutation	NOUN
dpc-571	68	7	in	in	ADP
dpc-571	68	8	a	a	DET
dpc-571	68	9	few	few	ADJ
dpc-571	68	10	additional	additional	ADJ
dpc-571	68	11	unknown	unknown	ADJ
dpc-571	68	12	high	high	ADJ
dpc-571	68	13	-	-	PUNCT
dpc-571	68	14	penetrance	penetrance	NOUN
dpc-571	68	15	genes	gene	NOUN
dpc-571	68	16	,	,	PUNCT
dpc-571	68	17	a	a	DET
dpc-571	68	18	polygenic	polygenic	ADJ
dpc-571	68	19	susceptibility	susceptibility	NOUN
dpc-571	68	20	as	as	ADP
dpc-571	68	21	result	result	NOUN
dpc-571	68	22	of	of	ADP
dpc-571	68	23	coinheritance	coinheritance	NOUN
dpc-571	68	24	of	of	ADP
dpc-571	68	25	multiple	multiple	ADJ
dpc-571	68	26	intermediateand	intermediateand	NOUN
dpc-571	68	27	/	/	SYM
dpc-571	68	28	or	or	CCONJ
dpc-571	68	29	low	low	ADJ
dpc-571	68	30	-	-	PUNCT
dpc-571	68	31	risk	risk	NOUN
dpc-571	68	32	alleles	allele	NOUN
dpc-571	68	33	or	or	CCONJ
dpc-571	68	34	an	an	DET
dpc-571	68	35	interplay	interplay	NOUN
dpc-571	68	36	between	between	ADP
dpc-571	68	37	susceptibility	susceptibility	NOUN
dpc-571	68	38	genes	gene	NOUN
dpc-571	68	39	and	and	CCONJ
dpc-571	68	40	genetic	genetic	ADJ
dpc-571	68	41	modifiers	modifier	NOUN
dpc-571	68	42	(	(	PUNCT
dpc-571	68	43	other	other	ADJ
dpc-571	68	44	genes	gene	NOUN
dpc-571	68	45	,	,	PUNCT
dpc-571	68	46	phenotypic	phenotypic	ADJ
dpc-571	68	47	characteristics	characteristic	NOUN
dpc-571	68	48	,	,	PUNCT
dpc-571	68	49	and/or	and/or	CCONJ
dpc-571	68	50	environmental	environmental	ADJ
dpc-571	68	51	risk	risk	NOUN
dpc-571	68	52	factors	factor	NOUN
dpc-571	68	53	)	)	PUNCT
dpc-571	68	54	has	have	AUX
dpc-571	68	55	been	be	AUX
dpc-571	68	56	suggested	suggest	VERB
dpc-571	68	57	.	.	PUNCT
dpc-571	69	1	two	two	NUM
dpc-571	69	2	intermediate	intermediate	ADJ
dpc-571	69	3	-	-	PUNCT
dpc-571	69	4	penetrance	penetrance	NOUN
dpc-571	69	5	genes	gene	NOUN
dpc-571	69	6	,	,	PUNCT
dpc-571	69	7	mc1r	mc1r	PROPN
dpc-571	69	8	and	and	CCONJ
dpc-571	69	9	mitf	mitf	NOUN
dpc-571	69	10	,	,	PUNCT
dpc-571	69	11	predisposing	predispose	VERB
dpc-571	69	12	to	to	ADP
dpc-571	69	13	melanoma	melanoma	NOUN
dpc-571	69	14	have	have	AUX
dpc-571	69	15	been	be	AUX
dpc-571	69	16	identified	identify	VERB
dpc-571	69	17	to	to	ADP
dpc-571	69	18	date	date	NOUN
dpc-571	69	19	(	(	PUNCT
dpc-571	69	20	table	table	NOUN
dpc-571	69	21	1	1	NUM
dpc-571	69	22	)	)	PUNCT
dpc-571	69	23	.	.	PUNCT
dpc-571	70	1	the	the	DET
dpc-571	70	2	mc1r	mc1r	PROPN
dpc-571	70	3	gene	gene	NOUN
dpc-571	70	4	,	,	PUNCT
dpc-571	70	5	encoding	encode	VERB
dpc-571	70	6	a	a	DET
dpc-571	70	7	g	g	NOUN
dpc-571	70	8	-	-	PUNCT
dpc-571	70	9	protein	protein	NOUN
dpc-571	70	10	coupled	couple	VERB
dpc-571	70	11	receptor	receptor	NOUN
dpc-571	70	12	with	with	ADP
dpc-571	70	13	a	a	DET
dpc-571	70	14	high	high	ADJ
dpc-571	70	15	affinity	affinity	NOUN
dpc-571	70	16	for	for	ADP
dpc-571	70	17	the	the	DET
dpc-571	70	18	α	α	NOUN
dpc-571	70	19	-	-	PUNCT
dpc-571	70	20	melanocyte	melanocyte	NOUN
dpc-571	70	21	-	-	PUNCT
dpc-571	70	22	stimulating	stimulate	VERB
dpc-571	70	23	hormone	hormone	NOUN
dpc-571	70	24	(	(	PUNCT
dpc-571	70	25	αmsh	αmsh	PROPN
dpc-571	70	26	)	)	PUNCT
dpc-571	70	27	,	,	PUNCT
dpc-571	70	28	has	have	VERB
dpc-571	70	29	a	a	DET
dpc-571	70	30	key	key	ADJ
dpc-571	70	31	role	role	NOUN
dpc-571	70	32	in	in	ADP
dpc-571	70	33	cutaneous	cutaneous	ADJ
dpc-571	70	34	pigmentation	pigmentation	NOUN
dpc-571	70	35	.	.	PUNCT
dpc-571	71	1	binding	bind	VERB
dpc-571	71	2	of	of	ADP
dpc-571	71	3	αmsh	αmsh	PROPN
dpc-571	71	4	to	to	ADP
dpc-571	71	5	mc1r	mc1r	PROPN
dpc-571	71	6	stimulates	stimulate	VERB
dpc-571	71	7	camp	camp	NOUN
dpc-571	71	8	-	-	PUNCT
dpc-571	71	9	induced	induce	VERB
dpc-571	71	10	tyrosinase	tyrosinase	NOUN
dpc-571	71	11	activity	activity	NOUN
dpc-571	71	12	resulting	result	VERB
dpc-571	71	13	in	in	ADP
dpc-571	71	14	eumelanin	eumelanin	ADJ
dpc-571	71	15	synthesis	synthesis	NOUN
dpc-571	71	16	.	.	PUNCT
dpc-571	72	1	mc1r	mc1r	PROPN
dpc-571	72	2	is	be	AUX
dpc-571	72	3	a	a	DET
dpc-571	72	4	highly	highly	ADV
dpc-571	72	5	polymorphic	polymorphic	ADJ
dpc-571	72	6	gene	gene	NOUN
dpc-571	72	7	in	in	ADP
dpc-571	72	8	the	the	DET
dpc-571	72	9	caucasian	caucasian	ADJ
dpc-571	72	10	population	population	NOUN
dpc-571	72	11	,	,	PUNCT
dpc-571	72	12	with	with	ADP
dpc-571	72	13	more	more	ADJ
dpc-571	72	14	than	than	ADP
dpc-571	72	15	100	100	NUM
dpc-571	72	16	variants	variant	NOUN
dpc-571	72	17	identified	identify	VERB
dpc-571	72	18	[	[	X
dpc-571	72	19	55,56	55,56	NOUN
dpc-571	72	20	]	]	PUNCT
dpc-571	72	21	.	.	PUNCT
dpc-571	73	1	specific	specific	ADJ
dpc-571	73	2	mc1r	mc1r	PROPN
dpc-571	73	3	variants	variant	NOUN
dpc-571	73	4	(	(	PUNCT
dpc-571	73	5	r142h	r142h	PROPN
dpc-571	73	6	,	,	PUNCT
dpc-571	73	7	r151c	r151c	PROPN
dpc-571	73	8	,	,	PUNCT
dpc-571	73	9	r160w	r160w	PROPN
dpc-571	73	10	,	,	PUNCT
dpc-571	73	11	and	and	CCONJ
dpc-571	73	12	d294h	d294h	PROPN
dpc-571	73	13	)	)	PUNCT
dpc-571	73	14	resulting	result	VERB
dpc-571	73	15	in	in	ADP
dpc-571	73	16	a	a	DET
dpc-571	73	17	reduced	reduce	VERB
dpc-571	73	18	receptor	receptor	NOUN
dpc-571	73	19	function	function	NOUN
dpc-571	73	20	with	with	ADP
dpc-571	73	21	a	a	DET
dpc-571	73	22	switch	switch	NOUN
dpc-571	73	23	from	from	ADP
dpc-571	73	24	eumelanin	eumelanin	NOUN
dpc-571	73	25	to	to	ADP
dpc-571	73	26	pheomelanin	pheomelanin	ADJ
dpc-571	73	27	synthesis	synthesis	NOUN
dpc-571	73	28	are	be	AUX
dpc-571	73	29	classified	classify	VERB
dpc-571	73	30	as	as	ADP
dpc-571	73	31	red	red	ADJ
dpc-571	73	32	hair	hair	NOUN
dpc-571	73	33	color	color	NOUN
dpc-571	73	34	(	(	PUNCT
dpc-571	73	35	rhc	rhc	NOUN
dpc-571	73	36	)	)	PUNCT
dpc-571	73	37	or	or	CCONJ
dpc-571	73	38	“	"	PUNCT
dpc-571	73	39	r	r	NOUN
dpc-571	73	40	”	"	PUNCT
dpc-571	73	41	variants	variant	NOUN
dpc-571	73	42	and	and	CCONJ
dpc-571	73	43	have	have	AUX
dpc-571	73	44	been	be	AUX
dpc-571	73	45	strongly	strongly	ADV
dpc-571	73	46	associated	associate	VERB
dpc-571	73	47	with	with	ADP
dpc-571	73	48	fair	fair	ADJ
dpc-571	73	49	skin	skin	NOUN
dpc-571	73	50	,	,	PUNCT
dpc-571	73	51	freckling	freckling	ADJ
dpc-571	73	52	,	,	PUNCT
dpc-571	73	53	uv	uv	NOUN
dpc-571	73	54	radiation	radiation	NOUN
dpc-571	73	55	sensitivity	sensitivity	NOUN
dpc-571	73	56	,	,	PUNCT
dpc-571	73	57	and	and	CCONJ
dpc-571	73	58	inability	inability	NOUN
dpc-571	73	59	to	to	ADP
dpc-571	73	60	tan	tan	PROPN
dpc-571	73	61	[	[	X
dpc-571	73	62	24,57	24,57	X
dpc-571	73	63	]	]	X
dpc-571	73	64	.	.	PUNCT
dpc-571	74	1	mc1r	mc1r	PROPN
dpc-571	74	2	variants	variant	NOUN
dpc-571	74	3	,	,	PUNCT
dpc-571	74	4	mainly	mainly	ADV
dpc-571	74	5	r	r	NOUN
dpc-571	74	6	alleles	allele	NOUN
dpc-571	74	7	,	,	PUNCT
dpc-571	74	8	have	have	AUX
dpc-571	74	9	been	be	AUX
dpc-571	74	10	associated	associate	VERB
dpc-571	74	11	with	with	ADP
dpc-571	74	12	an	an	DET
dpc-571	74	13	increased	increase	VERB
dpc-571	74	14	risk	risk	NOUN
dpc-571	74	15	of	of	ADP
dpc-571	74	16	melanoma	melanoma	NOUN
dpc-571	74	17	independently	independently	ADV
dpc-571	74	18	of	of	ADP
dpc-571	74	19	phenotypic	phenotypic	ADJ
dpc-571	74	20	features	feature	NOUN
dpc-571	74	21	[	[	X
dpc-571	74	22	56	56	NUM
dpc-571	74	23	]	]	PUNCT
dpc-571	74	24	.	.	PUNCT
dpc-571	75	1	notably	notably	ADV
dpc-571	75	2	,	,	PUNCT
dpc-571	75	3	a	a	DET
dpc-571	75	4	stronger	strong	ADJ
dpc-571	75	5	risk	risk	NOUN
dpc-571	75	6	has	have	AUX
dpc-571	75	7	been	be	AUX
dpc-571	75	8	reported	report	VERB
dpc-571	75	9	for	for	ADP
dpc-571	75	10	patients	patient	NOUN
dpc-571	75	11	with	with	ADP
dpc-571	75	12	darkly	darkly	ADV
dpc-571	75	13	pigmented	pigment	VERB
dpc-571	75	14	skin	skin	NOUN
dpc-571	75	15	[	[	X
dpc-571	75	16	23	23	NUM
dpc-571	75	17	]	]	PUNCT
dpc-571	75	18	.	.	PUNCT
dpc-571	76	1	it	it	PRON
dpc-571	76	2	is	be	AUX
dpc-571	76	3	indeed	indeed	ADV
dpc-571	76	4	recognized	recognize	VERB
dpc-571	76	5	that	that	SCONJ
dpc-571	76	6	mc1r	mc1r	PROPN
dpc-571	76	7	influences	influence	VERB
dpc-571	76	8	melanoma	melanoma	ADJ
dpc-571	76	9	risk	risk	NOUN
dpc-571	76	10	not	not	PART
dpc-571	76	11	only	only	ADV
dpc-571	76	12	through	through	ADP
dpc-571	76	13	its	its	PRON
dpc-571	76	14	effect	effect	NOUN
dpc-571	76	15	on	on	ADP
dpc-571	76	16	pigmentation	pigmentation	NOUN
dpc-571	76	17	and	and	CCONJ
dpc-571	76	18	uv	uv	NOUN
dpc-571	76	19	sensitivity	sensitivity	NOUN
dpc-571	76	20	but	but	CCONJ
dpc-571	76	21	also	also	ADV
dpc-571	76	22	through	through	ADP
dpc-571	76	23	additional	additional	ADJ
dpc-571	76	24	biological	biological	ADJ
dpc-571	76	25	pathways	pathway	NOUN
dpc-571	76	26	,	,	PUNCT
dpc-571	76	27	including	include	VERB
dpc-571	76	28	induction	induction	NOUN
dpc-571	76	29	of	of	ADP
dpc-571	76	30	antioxidant	antioxidant	ADJ
dpc-571	76	31	defenses	defense	NOUN
dpc-571	76	32	,	,	PUNCT
dpc-571	76	33	dna	dna	NOUN
dpc-571	76	34	repair	repair	NOUN
dpc-571	76	35	mechanisms	mechanism	NOUN
dpc-571	76	36	,	,	PUNCT
dpc-571	76	37	and	and	CCONJ
dpc-571	76	38	melanocyte	melanocyte	NOUN
dpc-571	76	39	proliferation	proliferation	NOUN
dpc-571	76	40	,	,	PUNCT
dpc-571	76	41	regulation	regulation	NOUN
dpc-571	76	42	,	,	PUNCT
dpc-571	76	43	and	and	CCONJ
dpc-571	76	44	differentiation	differentiation	NOUN
dpc-571	77	1	[	[	X
dpc-571	77	2	58	58	NUM
dpc-571	77	3	]	]	PUNCT
dpc-571	77	4	.	.	PUNCT
dpc-571	78	1	in	in	ADP
dpc-571	78	2	addition	addition	NOUN
dpc-571	78	3	,	,	PUNCT
dpc-571	78	4	inheritance	inheritance	NOUN
dpc-571	78	5	of	of	ADP
dpc-571	78	6	mc1r	mc1r	PROPN
dpc-571	78	7	variants	variant	NOUN
dpc-571	78	8	with	with	ADP
dpc-571	78	9	cdkn2a	cdkn2a	PROPN
dpc-571	78	10	mutations	mutation	NOUN
dpc-571	78	11	has	have	AUX
dpc-571	78	12	been	be	AUX
dpc-571	78	13	shown	show	VERB
dpc-571	78	14	to	to	PART
dpc-571	78	15	increase	increase	VERB
dpc-571	78	16	penetrance	penetrance	NOUN
dpc-571	78	17	of	of	ADP
dpc-571	78	18	melanoma	melanoma	NOUN
dpc-571	78	19	in	in	ADP
dpc-571	78	20	families	family	NOUN
dpc-571	78	21	carrying	carry	VERB
dpc-571	78	22	cdkn2a	cdkn2a	PROPN
dpc-571	78	23	mutations	mutation	NOUN
dpc-571	79	1	[	[	X
dpc-571	79	2	23,24	23,24	X
dpc-571	79	3	]	]	PUNCT
dpc-571	79	4	.	.	PUNCT
dpc-571	80	1	finally	finally	ADV
dpc-571	80	2	,	,	PUNCT
dpc-571	80	3	carrying	carry	VERB
dpc-571	80	4	r	r	NOUN
dpc-571	80	5	variants	variant	NOUN
dpc-571	80	6	has	have	AUX
dpc-571	80	7	been	be	AUX
dpc-571	80	8	associated	associate	VERB
dpc-571	80	9	with	with	ADP
dpc-571	80	10	specific	specific	ADJ
dpc-571	80	11	clinicodermoscopic	clinicodermoscopic	NOUN
dpc-571	80	12	features	feature	NOUN
dpc-571	80	13	of	of	ADP
dpc-571	80	14	melanoma	melanoma	NOUN
dpc-571	80	15	such	such	ADJ
dpc-571	80	16	as	as	ADP
dpc-571	80	17	hypopigmentation	hypopigmentation	NOUN
dpc-571	80	18	,	,	PUNCT
dpc-571	80	19	structureless	structureless	ADJ
dpc-571	80	20	areas	area	NOUN
dpc-571	80	21	,	,	PUNCT
dpc-571	80	22	atypia	atypia	PROPN
dpc-571	80	23	,	,	PUNCT
dpc-571	80	24	and	and	CCONJ
dpc-571	80	25	vessels	vessel	NOUN
dpc-571	80	26	[	[	PUNCT
dpc-571	80	27	59	59	NUM
dpc-571	80	28	-	-	SYM
dpc-571	80	29	61	61	NUM
dpc-571	80	30	]	]	PUNCT
dpc-571	80	31	.	.	PUNCT
dpc-571	81	1	the	the	DET
dpc-571	81	2	mitf	mitf	ADJ
dpc-571	81	3	gene	gene	NOUN
dpc-571	81	4	is	be	AUX
dpc-571	81	5	a	a	DET
dpc-571	81	6	master	master	NOUN
dpc-571	81	7	regulator	regulator	NOUN
dpc-571	81	8	of	of	ADP
dpc-571	81	9	melanocyte	melanocyte	NOUN
dpc-571	81	10	homeostasis	homeostasis	NOUN
dpc-571	81	11	encoding	encode	VERB
dpc-571	81	12	a	a	DET
dpc-571	81	13	lineage	lineage	NOUN
dpc-571	81	14	-	-	PUNCT
dpc-571	81	15	specific	specific	ADJ
dpc-571	81	16	transcription	transcription	NOUN
dpc-571	81	17	factor	factor	NOUN
dpc-571	81	18	,	,	PUNCT
dpc-571	81	19	involved	involve	VERB
dpc-571	81	20	in	in	ADP
dpc-571	81	21	cell	cell	NOUN
dpc-571	81	22	survival	survival	NOUN
dpc-571	81	23	,	,	PUNCT
dpc-571	81	24	differentiation	differentiation	NOUN
dpc-571	81	25	,	,	PUNCT
dpc-571	81	26	and	and	CCONJ
dpc-571	81	27	proliferation	proliferation	NOUN
dpc-571	81	28	[	[	X
dpc-571	81	29	62	62	NUM
dpc-571	81	30	]	]	PUNCT
dpc-571	81	31	.	.	PUNCT
dpc-571	82	1	a	a	DET
dpc-571	82	2	rare	rare	ADJ
dpc-571	82	3	functional	functional	ADJ
dpc-571	82	4	variant	variant	NOUN
dpc-571	82	5	p.e318k	p.e318k	PROPN
dpc-571	82	6	in	in	ADP
dpc-571	82	7	the	the	DET
dpc-571	82	8	mitf	mitf	ADJ
dpc-571	82	9	gene	gene	NOUN
dpc-571	82	10	has	have	AUX
dpc-571	82	11	been	be	AUX
dpc-571	82	12	implicated	implicate	VERB
dpc-571	82	13	in	in	ADP
dpc-571	82	14	familial	familial	ADJ
dpc-571	82	15	melanoma	melanoma	NOUN
dpc-571	82	16	and	and	CCONJ
dpc-571	82	17	in	in	ADP
dpc-571	82	18	melanoma	melanoma	NOUN
dpc-571	82	19	/	/	SYM
dpc-571	82	20	renal	renal	ADJ
dpc-571	82	21	cell	cell	NOUN
dpc-571	82	22	carcinoma	carcinoma	NOUN
dpc-571	82	23	susceptibility	susceptibility	NOUN
dpc-571	82	24	[	[	X
dpc-571	82	25	25,26	25,26	NUM
dpc-571	82	26	]	]	X
dpc-571	82	27	.	.	PUNCT
dpc-571	83	1	the	the	DET
dpc-571	83	2	p.e318k	p.e318k	PROPN
dpc-571	83	3	mutation	mutation	NOUN
dpc-571	83	4	alters	alter	VERB
dpc-571	83	5	mitf	mitf	ADJ
dpc-571	83	6	sumoylation	sumoylation	NOUN
dpc-571	83	7	,	,	PUNCT
dpc-571	83	8	increasing	increase	VERB
dpc-571	83	9	the	the	DET
dpc-571	83	10	mitf	mitf	ADJ
dpc-571	83	11	transcriptional	transcriptional	NOUN
dpc-571	83	12	activity	activity	NOUN
dpc-571	83	13	with	with	ADP
dpc-571	83	14	upregulation	upregulation	NOUN
dpc-571	83	15	of	of	ADP
dpc-571	83	16	downstream	downstream	ADJ
dpc-571	83	17	genes	gene	NOUN
dpc-571	83	18	.	.	PUNCT
dpc-571	84	1	clinically	clinically	ADV
dpc-571	84	2	,	,	PUNCT
dpc-571	84	3	a	a	DET
dpc-571	84	4	high	high	ADJ
dpc-571	84	5	nevus	nevus	ADJ
dpc-571	84	6	count	count	NOUN
dpc-571	84	7	,	,	PUNCT
dpc-571	84	8	development	development	NOUN
dpc-571	84	9	of	of	ADP
dpc-571	84	10	mpm	mpm	NOUN
dpc-571	84	11	,	,	PUNCT
dpc-571	84	12	onset	onset	NOUN
dpc-571	84	13	of	of	ADP
dpc-571	84	14	melanoma	melanoma	NOUN
dpc-571	84	15	before	before	ADP
dpc-571	84	16	the	the	DET
dpc-571	84	17	age	age	NOUN
dpc-571	84	18	of	of	ADP
dpc-571	84	19	40	40	NUM
dpc-571	84	20	,	,	PUNCT
dpc-571	84	21	and	and	CCONJ
dpc-571	84	22	nonblue	nonblue	ADJ
dpc-571	84	23	eye	eye	NOUN
dpc-571	84	24	color	color	NOUN
dpc-571	84	25	are	be	AUX
dpc-571	84	26	phenotypic	phenotypic	ADJ
dpc-571	84	27	characteristics	characteristic	NOUN
dpc-571	84	28	that	that	PRON
dpc-571	84	29	have	have	AUX
dpc-571	84	30	been	be	AUX
dpc-571	84	31	associated	associate	VERB
dpc-571	84	32	with	with	ADP
dpc-571	84	33	the	the	DET
dpc-571	84	34	p.e318k	p.e318k	PROPN
dpc-571	84	35	mutation	mutation	NOUN
dpc-571	84	36	[	[	X
dpc-571	84	37	25,63,64	25,63,64	NUM
dpc-571	84	38	]	]	X
dpc-571	84	39	.	.	PUNCT
dpc-571	85	1	the	the	DET
dpc-571	85	2	cdk4	cdk4	NOUN
dpc-571	85	3	oncogene	oncogene	NOUN
dpc-571	85	4	,	,	PUNCT
dpc-571	85	5	the	the	DET
dpc-571	85	6	second	second	ADJ
dpc-571	85	7	identified	identify	VERB
dpc-571	85	8	high	high	ADJ
dpc-571	85	9	-	-	PUNCT
dpc-571	85	10	risk	risk	NOUN
dpc-571	85	11	melanoma	melanoma	NOUN
dpc-571	85	12	susceptibility	susceptibility	NOUN
dpc-571	85	13	gene	gene	NOUN
dpc-571	85	14	,	,	PUNCT
dpc-571	85	15	encoding	encode	VERB
dpc-571	85	16	one	one	NUM
dpc-571	85	17	of	of	ADP
dpc-571	85	18	the	the	DET
dpc-571	85	19	binding	bind	VERB
dpc-571	85	20	partners	partner	NOUN
dpc-571	85	21	of	of	ADP
dpc-571	85	22	p16	p16	NOUN
dpc-571	85	23	.	.	PUNCT
dpc-571	86	1	the	the	DET
dpc-571	86	2	cdk4	cdk4	NOUN
dpc-571	86	3	oncogene	oncogene	NOUN
dpc-571	86	4	plays	play	VERB
dpc-571	86	5	an	an	DET
dpc-571	86	6	important	important	ADJ
dpc-571	86	7	role	role	NOUN
dpc-571	86	8	at	at	ADP
dpc-571	86	9	the	the	DET
dpc-571	86	10	g1	g1	PROPN
dpc-571	86	11	/	/	SYM
dpc-571	86	12	s	s	NOUN
dpc-571	86	13	phase	phase	NOUN
dpc-571	86	14	cell	cell	NOUN
dpc-571	86	15	cycle	cycle	NOUN
dpc-571	86	16	checkpoint	checkpoint	NOUN
dpc-571	86	17	(	(	PUNCT
dpc-571	86	18	1b	1b	NUM
dpc-571	86	19	)	)	PUNCT
dpc-571	86	20	.	.	PUNCT
dpc-571	87	1	when	when	SCONJ
dpc-571	87	2	cdk4	cdk4	NOUN
dpc-571	87	3	is	be	AUX
dpc-571	87	4	mutated	mutate	VERB
dpc-571	87	5	,	,	PUNCT
dpc-571	87	6	p16	p16	NOUN
dpc-571	87	7	can	can	AUX
dpc-571	87	8	not	not	PART
dpc-571	87	9	inhibit	inhibit	VERB
dpc-571	87	10	the	the	DET
dpc-571	87	11	cdk4	cdk4	NOUN
dpc-571	87	12	kinase	kinase	NOUN
dpc-571	87	13	activity	activity	NOUN
dpc-571	87	14	resulting	result	VERB
dpc-571	87	15	in	in	ADP
dpc-571	87	16	increased	increase	VERB
dpc-571	87	17	phosphorylation	phosphorylation	NOUN
dpc-571	87	18	of	of	ADP
dpc-571	87	19	rb	rb	NOUN
dpc-571	87	20	bound	bind	VERB
dpc-571	87	21	to	to	ADP
dpc-571	87	22	e2f	e2f	DET
dpc-571	87	23	transcription	transcription	NOUN
dpc-571	87	24	factors	factor	NOUN
dpc-571	87	25	with	with	ADP
dpc-571	87	26	higher	high	ADJ
dpc-571	87	27	e2f	e2f	DET
dpc-571	87	28	release	release	NOUN
dpc-571	87	29	.	.	PUNCT
dpc-571	88	1	e2f	e2f	PRON
dpc-571	88	2	activates	activate	VERB
dpc-571	88	3	the	the	DET
dpc-571	88	4	transcription	transcription	NOUN
dpc-571	88	5	of	of	ADP
dpc-571	88	6	pro	pro	ADJ
dpc-571	88	7	-	-	ADJ
dpc-571	88	8	s	s	ADJ
dpc-571	88	9	phase	phase	NOUN
dpc-571	88	10	cell	cell	NOUN
dpc-571	88	11	cycle	cycle	NOUN
dpc-571	88	12	genes	gene	NOUN
dpc-571	88	13	,	,	PUNCT
dpc-571	88	14	promoting	promote	VERB
dpc-571	88	15	g1	g1	PROPN
dpc-571	88	16	/	/	SYM
dpc-571	88	17	s	s	NOUN
dpc-571	88	18	phase	phase	NOUN
dpc-571	88	19	transition	transition	NOUN
dpc-571	88	20	.	.	PUNCT
dpc-571	89	1	all	all	DET
dpc-571	89	2	cdk4	cdk4	VERB
dpc-571	89	3	pathogenetic	pathogenetic	ADJ
dpc-571	89	4	mutations	mutation	NOUN
dpc-571	89	5	cluster	cluster	NOUN
dpc-571	89	6	in	in	ADP
dpc-571	89	7	codon	codon	PROPN
dpc-571	89	8	24	24	NUM
dpc-571	89	9	of	of	ADP
dpc-571	89	10	exon	exon	PROPN
dpc-571	89	11	2	2	NUM
dpc-571	89	12	,	,	PUNCT
dpc-571	89	13	a	a	DET
dpc-571	89	14	critical	critical	ADJ
dpc-571	89	15	site	site	NOUN
dpc-571	89	16	for	for	ADP
dpc-571	89	17	p16	p16	NOUN
dpc-571	89	18	binding	bind	VERB
dpc-571	89	19	[	[	X
dpc-571	89	20	16,47	16,47	NUM
dpc-571	89	21	]	]	X
dpc-571	89	22	.	.	PUNCT
dpc-571	90	1	the	the	DET
dpc-571	90	2	phenotype	phenotype	NOUN
dpc-571	90	3	of	of	ADP
dpc-571	90	4	cdk4	cdk4	NOUN
dpc-571	90	5	-	-	PUNCT
dpc-571	90	6	mutated	mutate	VERB
dpc-571	90	7	families	family	NOUN
dpc-571	90	8	is	be	AUX
dpc-571	90	9	indistinguishable	indistinguishable	ADJ
dpc-571	90	10	from	from	ADP
dpc-571	90	11	the	the	DET
dpc-571	90	12	cdkn2a	cdkn2a	PROPN
dpc-571	90	13	phenotype	phenotype	NOUN
dpc-571	90	14	,	,	PUNCT
dpc-571	90	15	with	with	ADP
dpc-571	90	16	early	early	ADJ
dpc-571	90	17	-	-	PUNCT
dpc-571	90	18	onset	onset	NOUN
dpc-571	90	19	cutaneous	cutaneous	ADJ
dpc-571	90	20	melanoma	melanoma	NOUN
dpc-571	90	21	,	,	PUNCT
dpc-571	90	22	development	development	NOUN
dpc-571	90	23	of	of	ADP
dpc-571	90	24	mpms	mpm	NOUN
dpc-571	90	25	,	,	PUNCT
dpc-571	90	26	and	and	CCONJ
dpc-571	90	27	presence	presence	NOUN
dpc-571	90	28	of	of	ADP
dpc-571	90	29	atypical	atypical	ADJ
dpc-571	90	30	nevi	nevi	NOUN
dpc-571	90	31	[	[	X
dpc-571	90	32	48	48	NUM
dpc-571	90	33	]	]	PUNCT
dpc-571	90	34	.	.	PUNCT
dpc-571	91	1	in	in	ADP
dpc-571	91	2	families	family	NOUN
dpc-571	91	3	negative	negative	ADJ
dpc-571	91	4	for	for	ADP
dpc-571	91	5	mutations	mutation	NOUN
dpc-571	91	6	in	in	ADP
dpc-571	91	7	known	know	VERB
dpc-571	91	8	high	high	ADJ
dpc-571	91	9	-	-	PUNCT
dpc-571	91	10	risk	risk	NOUN
dpc-571	91	11	genes	gene	NOUN
dpc-571	91	12	,	,	PUNCT
dpc-571	91	13	the	the	DET
dpc-571	91	14	introduction	introduction	NOUN
dpc-571	91	15	of	of	ADP
dpc-571	91	16	next	next	ADJ
dpc-571	91	17	-	-	PUNCT
dpc-571	91	18	generation	generation	NOUN
dpc-571	91	19	sequencing	sequencing	NOUN
dpc-571	91	20	methodologies	methodology	NOUN
dpc-571	91	21	led	lead	VERB
dpc-571	91	22	to	to	ADP
dpc-571	91	23	the	the	DET
dpc-571	91	24	identification	identification	NOUN
dpc-571	91	25	of	of	ADP
dpc-571	91	26	germline	germline	NOUN
dpc-571	91	27	mutations	mutation	NOUN
dpc-571	91	28	in	in	ADP
dpc-571	91	29	a	a	DET
dpc-571	91	30	small	small	ADJ
dpc-571	91	31	number	number	NOUN
dpc-571	91	32	of	of	ADP
dpc-571	91	33	novel	novel	ADJ
dpc-571	91	34	high	high	ADJ
dpc-571	91	35	-	-	PUNCT
dpc-571	91	36	penetrance	penetrance	NOUN
dpc-571	91	37	melanoma	melanoma	NOUN
dpc-571	91	38	susceptibility	susceptibility	NOUN
dpc-571	91	39	genes	gene	NOUN
dpc-571	91	40	involved	involve	VERB
dpc-571	91	41	in	in	ADP
dpc-571	91	42	pathways	pathway	NOUN
dpc-571	91	43	other	other	ADJ
dpc-571	91	44	than	than	ADP
dpc-571	91	45	those	those	PRON
dpc-571	91	46	mediated	mediate	VERB
dpc-571	91	47	by	by	ADP
dpc-571	91	48	known	know	VERB
dpc-571	91	49	melanoma	melanoma	NOUN
dpc-571	91	50	risk	risk	NOUN
dpc-571	91	51	factors	factor	NOUN
dpc-571	91	52	.	.	PUNCT
dpc-571	92	1	the	the	DET
dpc-571	92	2	bap1	bap1	PROPN
dpc-571	92	3	gene	gene	NOUN
dpc-571	92	4	regulates	regulate	VERB
dpc-571	92	5	differentiation	differentiation	NOUN
dpc-571	92	6	of	of	ADP
dpc-571	92	7	melanocytes	melanocyte	NOUN
dpc-571	92	8	and	and	CCONJ
dpc-571	92	9	is	be	AUX
dpc-571	92	10	part	part	NOUN
dpc-571	92	11	of	of	ADP
dpc-571	92	12	the	the	DET
dpc-571	92	13	dna	dna	PROPN
dpc-571	92	14	damage	damage	NOUN
dpc-571	92	15	response	response	NOUN
dpc-571	92	16	.	.	PUNCT
dpc-571	93	1	cutaneous	cutaneous	ADJ
dpc-571	93	2	melanoma	melanoma	NOUN
dpc-571	93	3	is	be	AUX
dpc-571	93	4	considered	consider	VERB
dpc-571	93	5	as	as	ADP
dpc-571	93	6	part	part	NOUN
dpc-571	93	7	of	of	ADP
dpc-571	93	8	the	the	DET
dpc-571	93	9	phenotype	phenotype	NOUN
dpc-571	93	10	associated	associate	VERB
dpc-571	93	11	with	with	ADP
dpc-571	93	12	the	the	DET
dpc-571	93	13	bap1	bap1	PROPN
dpc-571	93	14	cancer	cancer	NOUN
dpc-571	93	15	susceptibility	susceptibility	NOUN
dpc-571	93	16	syndrome	syndrome	PROPN
dpc-571	93	17	,	,	PUNCT
dpc-571	93	18	characterized	characterize	VERB
dpc-571	93	19	by	by	ADP
dpc-571	93	20	multiple	multiple	ADJ
dpc-571	93	21	skin	skin	NOUN
dpc-571	93	22	-	-	PUNCT
dpc-571	93	23	colored	color	VERB
dpc-571	93	24	spitzoid	spitzoid	ADJ
dpc-571	93	25	melanocytic	melanocytic	ADJ
dpc-571	93	26	tumors	tumor	NOUN
dpc-571	93	27	,	,	PUNCT
dpc-571	93	28	uveal	uveal	ADJ
dpc-571	93	29	melanoma	melanoma	NOUN
dpc-571	93	30	,	,	PUNCT
dpc-571	93	31	and	and	CCONJ
dpc-571	93	32	cutaneous	cutaneous	ADJ
dpc-571	93	33	melanoma	melanoma	NOUN
dpc-571	93	34	,	,	PUNCT
dpc-571	93	35	recently	recently	ADV
dpc-571	93	36	expanded	expand	VERB
dpc-571	93	37	to	to	PART
dpc-571	93	38	include	include	VERB
dpc-571	93	39	mesothelioma	mesothelioma	NOUN
dpc-571	93	40	,	,	PUNCT
dpc-571	93	41	renal	renal	ADJ
dpc-571	93	42	cell	cell	NOUN
dpc-571	93	43	carcinoma	carcinoma	NOUN
dpc-571	93	44	,	,	PUNCT
dpc-571	93	45	and	and	CCONJ
dpc-571	93	46	basal	basal	NOUN
dpc-571	93	47	cell	cell	NOUN
dpc-571	93	48	carcinoma	carcinoma	NOUN
dpc-571	94	1	[	[	X
dpc-571	94	2	49	49	NUM
dpc-571	94	3	-	-	SYM
dpc-571	94	4	53	53	NUM
dpc-571	94	5	]	]	PUNCT
dpc-571	94	6	.	.	PUNCT
dpc-571	95	1	the	the	DET
dpc-571	95	2	elevated	elevated	ADJ
dpc-571	95	3	number	number	NOUN
dpc-571	95	4	of	of	ADP
dpc-571	95	5	cancers	cancer	NOUN
dpc-571	95	6	in	in	ADP
dpc-571	95	7	bap1mutated	bap1mutated	PROPN
dpc-571	95	8	families	family	NOUN
dpc-571	95	9	suggests	suggest	VERB
dpc-571	95	10	that	that	SCONJ
dpc-571	95	11	this	this	DET
dpc-571	95	12	gene	gene	NOUN
dpc-571	95	13	is	be	AUX
dpc-571	95	14	a	a	DET
dpc-571	95	15	critical	critical	ADJ
dpc-571	95	16	regulator	regulator	NOUN
dpc-571	95	17	of	of	ADP
dpc-571	95	18	oncogenesis	oncogenesis	NOUN
dpc-571	95	19	.	.	PUNCT
dpc-571	96	1	telomere	telomere	NOUN
dpc-571	96	2	maintenance	maintenance	NOUN
dpc-571	96	3	has	have	AUX
dpc-571	96	4	been	be	AUX
dpc-571	96	5	recently	recently	ADV
dpc-571	96	6	discovered	discover	VERB
dpc-571	96	7	as	as	ADP
dpc-571	96	8	a	a	DET
dpc-571	96	9	key	key	ADJ
dpc-571	96	10	pathway	pathway	NOUN
dpc-571	96	11	in	in	ADP
dpc-571	96	12	melanoma	melanoma	NOUN
dpc-571	96	13	predisposition	predisposition	NOUN
dpc-571	96	14	(	(	PUNCT
dpc-571	96	15	figure	figure	NOUN
dpc-571	96	16	1c	1c	NOUN
dpc-571	96	17	)	)	PUNCT
dpc-571	96	18	.	.	PUNCT
dpc-571	97	1	the	the	DET
dpc-571	97	2	tert	tert	NOUN
dpc-571	97	3	gene	gene	NOUN
dpc-571	97	4	encodes	encode	VERB
dpc-571	97	5	the	the	DET
dpc-571	97	6	catalytic	catalytic	ADJ
dpc-571	97	7	subunit	subunit	NOUN
dpc-571	97	8	of	of	ADP
dpc-571	97	9	telomerase	telomerase	NOUN
dpc-571	97	10	,	,	PUNCT
dpc-571	97	11	which	which	PRON
dpc-571	97	12	is	be	AUX
dpc-571	97	13	the	the	DET
dpc-571	97	14	ribonucleoprotein	ribonucleoprotein	NOUN
dpc-571	97	15	complex	complex	NOUN
dpc-571	97	16	that	that	PRON
dpc-571	97	17	maintains	maintain	VERB
dpc-571	97	18	telomere	telomere	NOUN
dpc-571	97	19	length	length	NOUN
dpc-571	97	20	.	.	PUNCT
dpc-571	98	1	tert	tert	NOUN
dpc-571	98	2	mutations	mutation	NOUN
dpc-571	98	3	induce	induce	VERB
dpc-571	98	4	increased	increased	ADJ
dpc-571	98	5	expression	expression	NOUN
dpc-571	98	6	of	of	ADP
dpc-571	98	7	telomerase	telomerase	NOUN
dpc-571	98	8	,	,	PUNCT
dpc-571	98	9	thus	thus	ADV
dpc-571	98	10	promoting	promote	VERB
dpc-571	98	11	telomere	telomere	NOUN
dpc-571	98	12	stabilization	stabilization	NOUN
dpc-571	98	13	and	and	CCONJ
dpc-571	98	14	acting	act	VERB
dpc-571	98	15	on	on	ADP
dpc-571	98	16	cell	cell	NOUN
dpc-571	98	17	aging	aging	NOUN
dpc-571	98	18	,	,	PUNCT
dpc-571	98	19	turnover	turnover	NOUN
dpc-571	98	20	,	,	PUNCT
dpc-571	98	21	and	and	CCONJ
dpc-571	98	22	senescence	senescence	NOUN
dpc-571	98	23	.	.	PUNCT
dpc-571	99	1	a	a	DET
dpc-571	99	2	novel	novel	ADJ
dpc-571	99	3	mutation	mutation	NOUN
dpc-571	99	4	occurring	occur	VERB
dpc-571	99	5	in	in	ADP
dpc-571	99	6	the	the	DET
dpc-571	99	7	promoter	promoter	NOUN
dpc-571	99	8	region	region	NOUN
dpc-571	99	9	of	of	ADP
dpc-571	99	10	the	the	DET
dpc-571	99	11	tert	tert	NOUN
dpc-571	99	12	gene	gene	NOUN
dpc-571	99	13	,	,	PUNCT
dpc-571	99	14	encoding	encode	VERB
dpc-571	99	15	the	the	DET
dpc-571	99	16	catalytic	catalytic	ADJ
dpc-571	99	17	subunit	subunit	NOUN
dpc-571	99	18	of	of	ADP
dpc-571	99	19	telomerase	telomerase	NOUN
dpc-571	99	20	,	,	PUNCT
dpc-571	99	21	has	have	AUX
dpc-571	99	22	been	be	AUX
dpc-571	99	23	recently	recently	ADV
dpc-571	99	24	identified	identify	VERB
dpc-571	99	25	in	in	ADP
dpc-571	99	26	2	2	NUM
dpc-571	99	27	melanoma	melanoma	NOUN
dpc-571	99	28	families	family	NOUN
dpc-571	99	29	[	[	X
dpc-571	99	30	18,19	18,19	NUM
dpc-571	99	31	]	]	PUNCT
dpc-571	99	32	.	.	PUNCT
dpc-571	100	1	pot1	pot1	PROPN
dpc-571	100	2	is	be	AUX
dpc-571	100	3	a	a	DET
dpc-571	100	4	crucial	crucial	ADJ
dpc-571	100	5	member	member	NOUN
dpc-571	100	6	of	of	ADP
dpc-571	100	7	the	the	DET
dpc-571	100	8	shelterin	shelterin	NOUN
dpc-571	100	9	complex	complex	ADJ
dpc-571	100	10	proteins	protein	NOUN
dpc-571	100	11	,	,	PUNCT
dpc-571	100	12	important	important	ADJ
dpc-571	100	13	for	for	ADP
dpc-571	100	14	telomere	telomere	NOUN
dpc-571	100	15	maintenance	maintenance	NOUN
dpc-571	100	16	.	.	PUNCT
dpc-571	101	1	mutations	mutation	NOUN
dpc-571	101	2	in	in	ADP
dpc-571	101	3	the	the	DET
dpc-571	101	4	pot1	pot1	PROPN
dpc-571	101	5	gene	gene	NOUN
dpc-571	101	6	have	have	AUX
dpc-571	101	7	been	be	AUX
dpc-571	101	8	recently	recently	ADV
dpc-571	101	9	identified	identify	VERB
dpc-571	101	10	in	in	ADP
dpc-571	101	11	a	a	DET
dpc-571	101	12	total	total	NOUN
dpc-571	101	13	of	of	ADP
dpc-571	101	14	12	12	NUM
dpc-571	101	15	cdkn2a	cdkn2a	ADJ
dpc-571	101	16	-	-	PUNCT
dpc-571	101	17	negative	negative	ADJ
dpc-571	101	18	melanoma	melanoma	NOUN
dpc-571	101	19	families	family	NOUN
dpc-571	101	20	[	[	X
dpc-571	101	21	20,21	20,21	NUM
dpc-571	101	22	]	]	PUNCT
dpc-571	101	23	.	.	PUNCT
dpc-571	102	1	additional	additional	ADJ
dpc-571	102	2	shelterin	shelterin	NOUN
dpc-571	102	3	complex	complex	ADJ
dpc-571	102	4	genes	gene	NOUN
dpc-571	102	5	,	,	PUNCT
dpc-571	102	6	such	such	ADJ
dpc-571	102	7	as	as	ADP
dpc-571	102	8	acd	acd	NOUN
dpc-571	102	9	and	and	CCONJ
dpc-571	102	10	terf2ip	terf2ip	PROPN
dpc-571	102	11	,	,	PUNCT
dpc-571	102	12	were	be	AUX
dpc-571	102	13	later	later	ADV
dpc-571	102	14	found	find	VERB
dpc-571	102	15	to	to	PART
dpc-571	102	16	be	be	AUX
dpc-571	102	17	mutated	mutate	VERB
dpc-571	102	18	in	in	ADP
dpc-571	102	19	familial	familial	ADJ
dpc-571	102	20	melanoma	melanoma	NOUN
dpc-571	102	21	patients	patient	NOUN
dpc-571	102	22	[	[	X
dpc-571	102	23	54	54	NUM
dpc-571	102	24	]	]	PUNCT
dpc-571	102	25	.	.	PUNCT
dpc-571	103	1	overall	overall	ADV
dpc-571	103	2	,	,	PUNCT
dpc-571	103	3	germline	germline	NOUN
dpc-571	103	4	mutations	mutation	NOUN
dpc-571	103	5	in	in	ADP
dpc-571	103	6	pot1	pot1	PROPN
dpc-571	103	7	,	,	PUNCT
dpc-571	103	8	acd	acd	NOUN
dpc-571	103	9	,	,	PUNCT
dpc-571	103	10	and	and	CCONJ
dpc-571	103	11	terf2ip	terf2ip	NOUN
dpc-571	103	12	are	be	AUX
dpc-571	103	13	detected	detect	VERB
dpc-571	103	14	in	in	ADP
dpc-571	103	15	approximately	approximately	ADV
dpc-571	103	16	9	9	NUM
dpc-571	103	17	%	%	NOUN
dpc-571	103	18	of	of	ADP
dpc-571	103	19	high	high	ADJ
dpc-571	103	20	-	-	PUNCT
dpc-571	103	21	density	density	NOUN
dpc-571	103	22	families	family	NOUN
dpc-571	103	23	without	without	ADP
dpc-571	103	24	mutations	mutation	NOUN
dpc-571	103	25	in	in	ADP
dpc-571	103	26	known	know	VERB
dpc-571	103	27	high	high	ADJ
dpc-571	103	28	-	-	PUNCT
dpc-571	103	29	penetrance	penetrance	NOUN
dpc-571	103	30	genes	gene	NOUN
dpc-571	103	31	.	.	PUNCT
dpc-571	104	1	families	family	NOUN
dpc-571	104	2	carrying	carry	VERB
dpc-571	104	3	pot1	pot1	PROPN
dpc-571	104	4	,	,	PUNCT
dpc-571	104	5	acd	acd	NOUN
dpc-571	104	6	,	,	PUNCT
dpc-571	104	7	and	and	CCONJ
dpc-571	104	8	terf2ip	terf2ip	PRON
dpc-571	104	9	mutations	mutation	NOUN
dpc-571	104	10	often	often	ADV
dpc-571	104	11	present	present	VERB
dpc-571	104	12	with	with	ADP
dpc-571	104	13	mpm	mpm	NOUN
dpc-571	104	14	and	and	CCONJ
dpc-571	104	15	early	early	ADJ
dpc-571	104	16	-	-	PUNCT
dpc-571	104	17	onset	onset	NOUN
dpc-571	104	18	melanoma	melanoma	NOUN
dpc-571	104	19	.	.	PUNCT
dpc-571	105	1	14	14	NUM
dpc-571	105	2	review	review	NOUN
dpc-571	105	3	|	|	ADV
dpc-571	105	4	dermatol	dermatol	ADJ
dpc-571	105	5	pract	pract	NOUN
dpc-571	105	6	concept	concept	NOUN
dpc-571	105	7	2019;9(1):3	2019;9(1):3	PROPN
dpc-571	105	8	ing	e	VERB
dpc-571	105	9	the	the	DET
dpc-571	105	10	results	result	NOUN
dpc-571	105	11	and	and	CCONJ
dpc-571	105	12	the	the	DET
dpc-571	105	13	potential	potential	ADJ
dpc-571	105	14	limited	limited	ADJ
dpc-571	105	15	impact	impact	NOUN
dpc-571	105	16	on	on	ADP
dpc-571	105	17	clinical	clinical	ADJ
dpc-571	105	18	management	management	NOUN
dpc-571	105	19	.	.	PUNCT
dpc-571	106	1	in	in	ADP
dpc-571	106	2	patients	patient	NOUN
dpc-571	106	3	with	with	ADP
dpc-571	106	4	a	a	DET
dpc-571	106	5	strong	strong	ADJ
dpc-571	106	6	family	family	NOUN
dpc-571	106	7	history	history	NOUN
dpc-571	106	8	but	but	CCONJ
dpc-571	106	9	negative	negative	ADJ
dpc-571	106	10	for	for	ADP
dpc-571	106	11	cdkn2a	cdkn2a	PROPN
dpc-571	106	12	and	and	CCONJ
dpc-571	106	13	cdk4	cdk4	NOUN
dpc-571	106	14	mutations	mutation	NOUN
dpc-571	106	15	,	,	PUNCT
dpc-571	106	16	testing	test	VERB
dpc-571	106	17	for	for	ADP
dpc-571	106	18	other	other	ADJ
dpc-571	106	19	melanomaassociated	melanomaassociate	VERB
dpc-571	106	20	genes	gene	NOUN
dpc-571	106	21	can	can	AUX
dpc-571	106	22	be	be	AUX
dpc-571	106	23	performed	perform	VERB
dpc-571	106	24	:	:	PUNCT
dpc-571	106	25	bap1	bap1	PROPN
dpc-571	106	26	in	in	ADP
dpc-571	106	27	the	the	DET
dpc-571	106	28	presence	presence	NOUN
dpc-571	106	29	of	of	ADP
dpc-571	106	30	typical	typical	ADJ
dpc-571	106	31	cutaneous	cutaneous	ADJ
dpc-571	106	32	melanocytic	melanocytic	ADJ
dpc-571	106	33	lesions	lesion	NOUN
dpc-571	106	34	,	,	PUNCT
dpc-571	106	35	ocular	ocular	ADJ
dpc-571	106	36	melanoma	melanoma	NOUN
dpc-571	106	37	,	,	PUNCT
dpc-571	106	38	or	or	CCONJ
dpc-571	106	39	other	other	ADJ
dpc-571	106	40	associated	associated	ADJ
dpc-571	106	41	cancers	cancer	NOUN
dpc-571	106	42	described	describe	VERB
dpc-571	106	43	in	in	ADP
dpc-571	106	44	the	the	DET
dpc-571	106	45	bap1	bap1	PROPN
dpc-571	106	46	-	-	PUNCT
dpc-571	106	47	cancer	cancer	NOUN
dpc-571	106	48	susceptibility	susceptibility	NOUN
dpc-571	106	49	syndrome	syndrome	NOUN
dpc-571	106	50	or	or	CCONJ
dpc-571	106	51	mitf	mitf	VERB
dpc-571	106	52	in	in	ADP
dpc-571	106	53	the	the	DET
dpc-571	106	54	presence	presence	NOUN
dpc-571	106	55	of	of	ADP
dpc-571	106	56	renal	renal	ADJ
dpc-571	106	57	cell	cell	NOUN
dpc-571	106	58	carcinoma	carcinoma	NOUN
dpc-571	106	59	.	.	PUNCT
dpc-571	107	1	panel	panel	NOUN
dpc-571	107	2	testing	testing	NOUN
dpc-571	107	3	of	of	ADP
dpc-571	107	4	melanoma	melanoma	NOUN
dpc-571	107	5	predisposition	predisposition	NOUN
dpc-571	107	6	genes	gene	NOUN
dpc-571	107	7	is	be	AUX
dpc-571	107	8	an	an	DET
dpc-571	107	9	attractive	attractive	ADJ
dpc-571	107	10	option	option	NOUN
dpc-571	107	11	for	for	ADP
dpc-571	107	12	hereditary	hereditary	ADJ
dpc-571	107	13	melanoma	melanoma	NOUN
dpc-571	107	14	,	,	PUNCT
dpc-571	107	15	especially	especially	ADV
dpc-571	107	16	for	for	ADP
dpc-571	107	17	high	high	ADJ
dpc-571	107	18	-	-	PUNCT
dpc-571	107	19	penetrance	penetrance	NOUN
dpc-571	107	20	genes	gene	NOUN
dpc-571	107	21	,	,	PUNCT
dpc-571	107	22	and	and	CCONJ
dpc-571	107	23	by	by	ADP
dpc-571	107	24	now	now	ADV
dpc-571	107	25	numerous	numerous	ADJ
dpc-571	107	26	panel	panel	NOUN
dpc-571	107	27	tests	test	NOUN
dpc-571	107	28	are	be	AUX
dpc-571	107	29	available	available	ADJ
dpc-571	107	30	at	at	ADP
dpc-571	107	31	the	the	DET
dpc-571	107	32	same	same	ADJ
dpc-571	107	33	cost	cost	NOUN
dpc-571	107	34	as	as	ADP
dpc-571	107	35	a	a	DET
dpc-571	107	36	single	single	ADJ
dpc-571	107	37	gene	gene	NOUN
dpc-571	107	38	test	test	NOUN
dpc-571	107	39	.	.	PUNCT
dpc-571	108	1	however	however	ADV
dpc-571	108	2	,	,	PUNCT
dpc-571	108	3	routine	routine	ADJ
dpc-571	108	4	screening	screening	NOUN
dpc-571	108	5	of	of	ADP
dpc-571	108	6	intermediateor	intermediateor	NOUN
dpc-571	108	7	low	low	ADJ
dpc-571	108	8	-	-	PUNCT
dpc-571	108	9	penetrance	penetrance	NOUN
dpc-571	108	10	genes	gene	NOUN
dpc-571	108	11	is	be	AUX
dpc-571	108	12	questionable	questionable	ADJ
dpc-571	108	13	because	because	SCONJ
dpc-571	108	14	of	of	ADP
dpc-571	108	15	the	the	DET
dpc-571	108	16	uncertainty	uncertainty	NOUN
dpc-571	108	17	of	of	ADP
dpc-571	108	18	predicting	predict	VERB
dpc-571	108	19	clinical	clinical	ADJ
dpc-571	108	20	outcome	outcome	NOUN
dpc-571	108	21	of	of	ADP
dpc-571	108	22	disease	disease	NOUN
dpc-571	108	23	development	development	NOUN
dpc-571	108	24	.	.	PUNCT
dpc-571	109	1	however	however	ADV
dpc-571	109	2	,	,	PUNCT
dpc-571	109	3	a	a	DET
dpc-571	109	4	tailored	tailor	VERB
dpc-571	109	5	genetic	genetic	ADJ
dpc-571	109	6	testing	testing	NOUN
dpc-571	109	7	approach	approach	NOUN
dpc-571	109	8	with	with	ADP
dpc-571	109	9	multigene	multigene	ADJ
dpc-571	109	10	panels	panel	NOUN
dpc-571	109	11	based	base	VERB
dpc-571	109	12	on	on	ADP
dpc-571	109	13	the	the	DET
dpc-571	109	14	cancer	cancer	NOUN
dpc-571	109	15	profile	profile	NOUN
dpc-571	109	16	observed	observe	VERB
dpc-571	109	17	in	in	ADP
dpc-571	109	18	the	the	DET
dpc-571	109	19	family	family	NOUN
dpc-571	109	20	could	could	AUX
dpc-571	109	21	be	be	AUX
dpc-571	109	22	performed	perform	VERB
dpc-571	109	23	if	if	SCONJ
dpc-571	109	24	in	in	ADP
dpc-571	109	25	the	the	DET
dpc-571	109	26	families	family	NOUN
dpc-571	109	27	there	there	PRON
dpc-571	109	28	are	be	VERB
dpc-571	109	29	cases	case	NOUN
dpc-571	109	30	of	of	ADP
dpc-571	109	31	breast	breast	NOUN
dpc-571	109	32	cancer	cancer	NOUN
dpc-571	109	33	,	,	PUNCT
dpc-571	109	34	prostate	prostate	NOUN
dpc-571	109	35	cancer	cancer	NOUN
dpc-571	109	36	,	,	PUNCT
dpc-571	109	37	ovarian	ovarian	ADJ
dpc-571	109	38	cancer	cancer	NOUN
dpc-571	109	39	,	,	PUNCT
dpc-571	109	40	and/or	and/or	CCONJ
dpc-571	109	41	colon	colon	NOUN
dpc-571	109	42	cancer	cancer	NOUN
dpc-571	109	43	[	[	X
dpc-571	109	44	45	45	NUM
dpc-571	109	45	]	]	PUNCT
dpc-571	109	46	.	.	PUNCT
dpc-571	110	1	management	management	NOUN
dpc-571	110	2	of	of	ADP
dpc-571	110	3	familial	familial	ADJ
dpc-571	110	4	melanoma	melanoma	NOUN
dpc-571	110	5	patients	patient	NOUN
dpc-571	110	6	carriers	carrier	NOUN
dpc-571	110	7	of	of	ADP
dpc-571	110	8	a	a	DET
dpc-571	110	9	cdkn2a	cdkn2a	PROPN
dpc-571	110	10	mutation	mutation	NOUN
dpc-571	110	11	are	be	AUX
dpc-571	110	12	at	at	ADP
dpc-571	110	13	high	high	ADJ
dpc-571	110	14	risk	risk	NOUN
dpc-571	110	15	of	of	ADP
dpc-571	110	16	developing	develop	VERB
dpc-571	110	17	multiple	multiple	ADJ
dpc-571	110	18	melanomas	melanoma	NOUN
dpc-571	110	19	and	and	CCONJ
dpc-571	110	20	,	,	PUNCT
dpc-571	110	21	in	in	ADP
dpc-571	110	22	some	some	DET
dpc-571	110	23	families	family	NOUN
dpc-571	110	24	,	,	PUNCT
dpc-571	110	25	pancreatic	pancreatic	ADJ
dpc-571	110	26	cancer	cancer	NOUN
dpc-571	110	27	[	[	X
dpc-571	110	28	12,13	12,13	NUM
dpc-571	110	29	]	]	PUNCT
dpc-571	110	30	.	.	PUNCT
dpc-571	111	1	the	the	DET
dpc-571	111	2	identification	identification	NOUN
dpc-571	111	3	of	of	ADP
dpc-571	111	4	a	a	DET
dpc-571	111	5	deleterious	deleterious	ADJ
dpc-571	111	6	cdkn2a	cdkn2a	PROPN
dpc-571	111	7	mutation	mutation	NOUN
dpc-571	111	8	suggests	suggest	VERB
dpc-571	111	9	that	that	SCONJ
dpc-571	111	10	carriers	carrier	NOUN
dpc-571	111	11	should	should	AUX
dpc-571	111	12	be	be	AUX
dpc-571	111	13	included	include	VERB
dpc-571	111	14	in	in	ADP
dpc-571	111	15	intensive	intensive	ADJ
dpc-571	111	16	skin	skin	NOUN
dpc-571	111	17	surveillance	surveillance	NOUN
dpc-571	111	18	programs	program	NOUN
dpc-571	111	19	with	with	ADP
dpc-571	111	20	skin	skin	NOUN
dpc-571	111	21	examination	examination	NOUN
dpc-571	111	22	,	,	PUNCT
dpc-571	111	23	also	also	ADV
dpc-571	111	24	including	include	VERB
dpc-571	111	25	scalp	scalp	NOUN
dpc-571	111	26	,	,	PUNCT
dpc-571	111	27	oral	oral	ADJ
dpc-571	111	28	and	and	CCONJ
dpc-571	111	29	genital	genital	ADJ
dpc-571	111	30	mucosa	mucosa	NOUN
dpc-571	111	31	,	,	PUNCT
dpc-571	111	32	performed	perform	VERB
dpc-571	111	33	every	every	DET
dpc-571	111	34	6	6	NUM
dpc-571	111	35	months	month	NOUN
dpc-571	111	36	.	.	PUNCT
dpc-571	112	1	however	however	ADV
dpc-571	112	2	,	,	PUNCT
dpc-571	112	3	the	the	DET
dpc-571	112	4	frequency	frequency	NOUN
dpc-571	112	5	of	of	ADP
dpc-571	112	6	dermatological	dermatological	ADJ
dpc-571	112	7	visit	visit	NOUN
dpc-571	112	8	(	(	PUNCT
dpc-571	112	9	3	3	NUM
dpc-571	112	10	-	-	PUNCT
dpc-571	112	11	month	month	NOUN
dpc-571	112	12	,	,	PUNCT
dpc-571	112	13	6	6	NUM
dpc-571	112	14	-	-	PUNCT
dpc-571	112	15	month	month	NOUN
dpc-571	112	16	,	,	PUNCT
dpc-571	112	17	or	or	CCONJ
dpc-571	112	18	1	1	NUM
dpc-571	112	19	-	-	PUNCT
dpc-571	112	20	year	year	NOUN
dpc-571	112	21	intervals	interval	NOUN
dpc-571	112	22	)	)	PUNCT
dpc-571	112	23	should	should	AUX
dpc-571	112	24	be	be	AUX
dpc-571	112	25	planned	plan	VERB
dpc-571	112	26	on	on	ADP
dpc-571	112	27	the	the	DET
dpc-571	112	28	basis	basis	NOUN
dpc-571	112	29	of	of	ADP
dpc-571	112	30	the	the	DET
dpc-571	112	31	patient	patient	NOUN
dpc-571	112	32	’s	’s	PART
dpc-571	112	33	risk	risk	NOUN
dpc-571	112	34	factors	factor	NOUN
dpc-571	112	35	;	;	PUNCT
dpc-571	112	36	digital	digital	ADJ
dpc-571	112	37	dermoscopy	dermoscopy	NOUN
dpc-571	112	38	and	and	CCONJ
dpc-571	112	39	clinical	clinical	ADJ
dpc-571	112	40	photography	photography	NOUN
dpc-571	112	41	would	would	AUX
dpc-571	112	42	be	be	AUX
dpc-571	112	43	helpful	helpful	ADJ
dpc-571	112	44	for	for	ADP
dpc-571	112	45	monitoring	monitor	VERB
dpc-571	112	46	these	these	DET
dpc-571	112	47	patients	patient	NOUN
dpc-571	112	48	.	.	PUNCT
dpc-571	113	1	with	with	ADP
dpc-571	113	2	regard	regard	NOUN
dpc-571	113	3	to	to	ADP
dpc-571	113	4	pancreatic	pancreatic	ADJ
dpc-571	113	5	cancer	cancer	NOUN
dpc-571	113	6	,	,	PUNCT
dpc-571	113	7	patients	patient	NOUN
dpc-571	113	8	should	should	AUX
dpc-571	113	9	be	be	AUX
dpc-571	113	10	aware	aware	ADJ
dpc-571	113	11	of	of	ADP
dpc-571	113	12	the	the	DET
dpc-571	113	13	current	current	ADJ
dpc-571	113	14	lack	lack	NOUN
dpc-571	113	15	of	of	ADP
dpc-571	113	16	effective	effective	ADJ
dpc-571	113	17	screening	screening	NOUN
dpc-571	113	18	guidelines	guideline	NOUN
dpc-571	113	19	[	[	X
dpc-571	113	20	46,66	46,66	NOUN
dpc-571	113	21	]	]	X
dpc-571	113	22	.	.	PUNCT
dpc-571	114	1	overall	overall	ADV
dpc-571	114	2	,	,	PUNCT
dpc-571	114	3	cdkn2a	cdkn2a	PROPN
dpc-571	114	4	carriers	carrier	NOUN
dpc-571	114	5	are	be	AUX
dpc-571	114	6	candidates	candidate	NOUN
dpc-571	114	7	for	for	ADP
dpc-571	114	8	annual	annual	ADJ
dpc-571	114	9	genetic	genetic	ADJ
dpc-571	114	10	counseling	counseling	NOUN
dpc-571	114	11	and	and	CCONJ
dpc-571	114	12	testing	test	VERB
dpc-571	114	13	genetic	genetic	ADJ
dpc-571	114	14	counseling	counseling	NOUN
dpc-571	114	15	should	should	AUX
dpc-571	114	16	be	be	AUX
dpc-571	114	17	offered	offer	VERB
dpc-571	114	18	to	to	PART
dpc-571	114	19	melanoma	melanoma	VERB
dpc-571	114	20	patients	patient	NOUN
dpc-571	114	21	with	with	ADP
dpc-571	114	22	hereditary	hereditary	ADJ
dpc-571	114	23	predisposition	predisposition	NOUN
dpc-571	114	24	so	so	SCONJ
dpc-571	114	25	that	that	SCONJ
dpc-571	114	26	they	they	PRON
dpc-571	114	27	may	may	AUX
dpc-571	114	28	better	well	ADV
dpc-571	114	29	understand	understand	VERB
dpc-571	114	30	the	the	DET
dpc-571	114	31	meaning	meaning	NOUN
dpc-571	114	32	of	of	ADP
dpc-571	114	33	the	the	DET
dpc-571	114	34	disease	disease	NOUN
dpc-571	114	35	,	,	PUNCT
dpc-571	114	36	pattern	pattern	NOUN
dpc-571	114	37	of	of	ADP
dpc-571	114	38	inheritance	inheritance	NOUN
dpc-571	114	39	,	,	PUNCT
dpc-571	114	40	option	option	NOUN
dpc-571	114	41	of	of	ADP
dpc-571	114	42	genetic	genetic	ADJ
dpc-571	114	43	testing	testing	NOUN
dpc-571	114	44	,	,	PUNCT
dpc-571	114	45	possible	possible	ADJ
dpc-571	114	46	results	result	NOUN
dpc-571	114	47	and	and	CCONJ
dpc-571	114	48	implications	implication	NOUN
dpc-571	114	49	for	for	ADP
dpc-571	114	50	other	other	ADJ
dpc-571	114	51	family	family	NOUN
dpc-571	114	52	members	member	NOUN
dpc-571	114	53	,	,	PUNCT
dpc-571	114	54	and	and	CCONJ
dpc-571	114	55	recommendations	recommendation	NOUN
dpc-571	114	56	for	for	ADP
dpc-571	114	57	primary	primary	ADJ
dpc-571	114	58	and	and	CCONJ
dpc-571	114	59	secondary	secondary	ADJ
dpc-571	114	60	prevention	prevention	NOUN
dpc-571	114	61	of	of	ADP
dpc-571	114	62	melanoma	melanoma	NOUN
dpc-571	114	63	and	and	CCONJ
dpc-571	114	64	for	for	ADP
dpc-571	114	65	psychological	psychological	ADJ
dpc-571	114	66	assessment	assessment	NOUN
dpc-571	114	67	[	[	X
dpc-571	114	68	34,65	34,65	NOUN
dpc-571	114	69	]	]	PUNCT
dpc-571	114	70	.	.	PUNCT
dpc-571	115	1	to	to	ADP
dpc-571	115	2	date	date	NOUN
dpc-571	115	3	,	,	PUNCT
dpc-571	115	4	cdkn2a	cdkn2a	PROPN
dpc-571	115	5	and	and	CCONJ
dpc-571	115	6	cdk4	cdk4	NOUN
dpc-571	115	7	are	be	AUX
dpc-571	115	8	the	the	DET
dpc-571	115	9	only	only	ADJ
dpc-571	115	10	genes	gene	NOUN
dpc-571	115	11	recommended	recommend	VERB
dpc-571	115	12	to	to	PART
dpc-571	115	13	be	be	AUX
dpc-571	115	14	tested	test	VERB
dpc-571	115	15	as	as	ADP
dpc-571	115	16	single	single	ADJ
dpc-571	115	17	genes	gene	NOUN
dpc-571	115	18	for	for	ADP
dpc-571	115	19	genetic	genetic	ADJ
dpc-571	115	20	screening	screening	NOUN
dpc-571	115	21	of	of	ADP
dpc-571	115	22	melanoma	melanoma	NOUN
dpc-571	115	23	predisposition	predisposition	NOUN
dpc-571	116	1	[	[	X
dpc-571	116	2	8,31,45	8,31,45	NUM
dpc-571	116	3	]	]	PUNCT
dpc-571	116	4	.	.	PUNCT
dpc-571	117	1	genetic	genetic	ADJ
dpc-571	117	2	testing	testing	NOUN
dpc-571	117	3	of	of	ADP
dpc-571	117	4	the	the	DET
dpc-571	117	5	cdkn2a	cdkn2a	PROPN
dpc-571	117	6	gene	gene	NOUN
dpc-571	117	7	has	have	AUX
dpc-571	117	8	been	be	AUX
dpc-571	117	9	available	available	ADJ
dpc-571	117	10	for	for	ADP
dpc-571	117	11	a	a	DET
dpc-571	117	12	long	long	ADJ
dpc-571	117	13	time	time	NOUN
dpc-571	117	14	and	and	CCONJ
dpc-571	117	15	can	can	AUX
dpc-571	117	16	be	be	AUX
dpc-571	117	17	offered	offer	VERB
dpc-571	117	18	to	to	ADP
dpc-571	117	19	patients	patient	NOUN
dpc-571	117	20	with	with	ADP
dpc-571	117	21	familial	familial	ADJ
dpc-571	117	22	melanoma	melanoma	NOUN
dpc-571	117	23	and/or	and/or	CCONJ
dpc-571	117	24	mpm	mpm	NOUN
dpc-571	117	25	who	who	PRON
dpc-571	117	26	are	be	AUX
dpc-571	117	27	likely	likely	ADJ
dpc-571	117	28	to	to	PART
dpc-571	117	29	carry	carry	VERB
dpc-571	117	30	a	a	DET
dpc-571	117	31	cdkn2a	cdkn2a	PROPN
dpc-571	117	32	mutation	mutation	NOUN
dpc-571	117	33	.	.	PUNCT
dpc-571	118	1	however	however	ADV
dpc-571	118	2	,	,	PUNCT
dpc-571	118	3	its	its	PRON
dpc-571	118	4	use	use	NOUN
dpc-571	118	5	in	in	ADP
dpc-571	118	6	clinical	clinical	ADJ
dpc-571	118	7	practice	practice	NOUN
dpc-571	118	8	has	have	AUX
dpc-571	118	9	been	be	AUX
dpc-571	118	10	controversial	controversial	ADJ
dpc-571	118	11	because	because	SCONJ
dpc-571	118	12	of	of	ADP
dpc-571	118	13	the	the	DET
dpc-571	118	14	reported	report	VERB
dpc-571	118	15	variation	variation	NOUN
dpc-571	118	16	in	in	ADP
dpc-571	118	17	the	the	DET
dpc-571	118	18	estimates	estimate	NOUN
dpc-571	118	19	of	of	ADP
dpc-571	118	20	cdkn2a	cdkn2a	PROPN
dpc-571	118	21	mutation	mutation	NOUN
dpc-571	118	22	penetrance	penetrance	NOUN
dpc-571	118	23	,	,	PUNCT
dpc-571	118	24	depending	depend	VERB
dpc-571	118	25	on	on	ADP
dpc-571	118	26	selection	selection	NOUN
dpc-571	118	27	criteria	criterion	NOUN
dpc-571	118	28	of	of	ADP
dpc-571	118	29	patients	patient	NOUN
dpc-571	118	30	,	,	PUNCT
dpc-571	118	31	ethnic	ethnic	ADJ
dpc-571	118	32	background	background	NOUN
dpc-571	118	33	,	,	PUNCT
dpc-571	118	34	environmental	environmental	ADJ
dpc-571	118	35	exposure	exposure	NOUN
dpc-571	118	36	,	,	PUNCT
dpc-571	118	37	and	and	CCONJ
dpc-571	118	38	coinheritance	coinheritance	NOUN
dpc-571	118	39	of	of	ADP
dpc-571	118	40	low	low	ADJ
dpc-571	118	41	-	-	PUNCT
dpc-571	118	42	intermediate	intermediate	ADJ
dpc-571	118	43	predisposing	predispose	VERB
dpc-571	118	44	genes	gene	NOUN
dpc-571	118	45	such	such	ADJ
dpc-571	118	46	as	as	ADP
dpc-571	118	47	mc1r	mc1r	PROPN
dpc-571	118	48	variants	variant	NOUN
dpc-571	118	49	.	.	PUNCT
dpc-571	119	1	leachman	leachman	PROPN
dpc-571	119	2	et	et	PROPN
dpc-571	119	3	 	 	SPACE
dpc-571	119	4	al	al	PROPN
dpc-571	120	1	[	[	X
dpc-571	120	2	31	31	NUM
dpc-571	120	3	]	]	PUNCT
dpc-571	120	4	proposed	propose	VERB
dpc-571	120	5	a	a	DET
dpc-571	120	6	useful	useful	ADJ
dpc-571	120	7	rule	rule	NOUN
dpc-571	120	8	to	to	PART
dpc-571	120	9	select	select	VERB
dpc-571	120	10	appropriate	appropriate	ADJ
dpc-571	120	11	candidates	candidate	NOUN
dpc-571	120	12	eligible	eligible	ADJ
dpc-571	120	13	for	for	ADP
dpc-571	120	14	genetic	genetic	ADJ
dpc-571	120	15	testing	testing	NOUN
dpc-571	120	16	in	in	ADP
dpc-571	120	17	melanoma	melanoma	NOUN
dpc-571	120	18	with	with	ADP
dpc-571	120	19	regard	regard	NOUN
dpc-571	120	20	to	to	ADP
dpc-571	120	21	the	the	DET
dpc-571	120	22	specific	specific	ADJ
dpc-571	120	23	population	population	NOUN
dpc-571	120	24	or	or	CCONJ
dpc-571	120	25	geographic	geographic	ADJ
dpc-571	120	26	area	area	NOUN
dpc-571	120	27	(	(	PUNCT
dpc-571	120	28	table	table	NOUN
dpc-571	120	29	2	2	NUM
dpc-571	120	30	):	):	PUNCT
dpc-571	120	31	the	the	DET
dpc-571	120	32	rule	rule	NOUN
dpc-571	120	33	of	of	ADP
dpc-571	120	34	2	2	NUM
dpc-571	120	35	for	for	ADP
dpc-571	120	36	countries	country	NOUN
dpc-571	120	37	with	with	ADP
dpc-571	120	38	a	a	DET
dpc-571	120	39	low	low	ADJ
dpc-571	120	40	incidence	incidence	NOUN
dpc-571	120	41	of	of	ADP
dpc-571	120	42	melanoma	melanoma	NOUN
dpc-571	120	43	(	(	PUNCT
dpc-571	120	44	southern	southern	ADJ
dpc-571	120	45	europe	europe	PROPN
dpc-571	120	46	)	)	PUNCT
dpc-571	120	47	and	and	CCONJ
dpc-571	120	48	the	the	DET
dpc-571	120	49	rule	rule	NOUN
dpc-571	120	50	of	of	ADP
dpc-571	120	51	3	3	NUM
dpc-571	120	52	for	for	ADP
dpc-571	120	53	countries	country	NOUN
dpc-571	120	54	with	with	ADP
dpc-571	120	55	a	a	DET
dpc-571	120	56	moderate	moderate	ADJ
dpc-571	120	57	–	–	PUNCT
dpc-571	120	58	high	high	ADJ
dpc-571	120	59	incidence	incidence	NOUN
dpc-571	120	60	of	of	ADP
dpc-571	120	61	melanoma	melanoma	NOUN
dpc-571	120	62	(	(	PUNCT
dpc-571	120	63	united	united	PROPN
dpc-571	120	64	states	states	PROPN
dpc-571	120	65	and	and	CCONJ
dpc-571	120	66	northern	northern	ADJ
dpc-571	120	67	europe	europe	PROPN
dpc-571	120	68	)	)	PUNCT
dpc-571	120	69	.	.	PUNCT
dpc-571	121	1	a	a	DET
dpc-571	121	2	rule	rule	NOUN
dpc-571	121	3	of	of	ADP
dpc-571	121	4	4	4	NUM
dpc-571	121	5	for	for	ADP
dpc-571	121	6	countries	country	NOUN
dpc-571	121	7	with	with	ADP
dpc-571	121	8	a	a	DET
dpc-571	121	9	very	very	ADV
dpc-571	121	10	high	high	ADJ
dpc-571	121	11	incidence	incidence	NOUN
dpc-571	121	12	of	of	ADP
dpc-571	121	13	melanoma	melanoma	NOUN
dpc-571	121	14	(	(	PUNCT
dpc-571	121	15	australia	australia	PROPN
dpc-571	121	16	)	)	PUNCT
dpc-571	121	17	has	have	AUX
dpc-571	121	18	been	be	AUX
dpc-571	121	19	suggested	suggest	VERB
dpc-571	121	20	[	[	X
dpc-571	121	21	65	65	NUM
dpc-571	121	22	]	]	PUNCT
dpc-571	121	23	.	.	PUNCT
dpc-571	122	1	to	to	PART
dpc-571	122	2	reduce	reduce	VERB
dpc-571	122	3	the	the	DET
dpc-571	122	4	risk	risk	NOUN
dpc-571	122	5	of	of	ADP
dpc-571	122	6	uninformative	uninformative	ADJ
dpc-571	122	7	negative	negative	ADJ
dpc-571	122	8	results	result	NOUN
dpc-571	122	9	,	,	PUNCT
dpc-571	122	10	it	it	PRON
dpc-571	122	11	is	be	AUX
dpc-571	122	12	important	important	ADJ
dpc-571	122	13	to	to	PART
dpc-571	122	14	identify	identify	VERB
dpc-571	122	15	the	the	DET
dpc-571	122	16	best	good	ADJ
dpc-571	122	17	candidate	candidate	NOUN
dpc-571	122	18	in	in	ADP
dpc-571	122	19	the	the	DET
dpc-571	122	20	family	family	NOUN
dpc-571	122	21	for	for	ADP
dpc-571	122	22	genetic	genetic	ADJ
dpc-571	122	23	testing	testing	NOUN
dpc-571	122	24	,	,	PUNCT
dpc-571	122	25	usually	usually	ADV
dpc-571	122	26	an	an	DET
dpc-571	122	27	individual	individual	NOUN
dpc-571	122	28	with	with	ADP
dpc-571	122	29	a	a	DET
dpc-571	122	30	personal	personal	ADJ
dpc-571	122	31	presentation	presentation	NOUN
dpc-571	122	32	most	most	ADV
dpc-571	122	33	suggestive	suggestive	ADJ
dpc-571	122	34	of	of	ADP
dpc-571	122	35	a	a	DET
dpc-571	122	36	cdkn2a	cdkn2a	PROPN
dpc-571	122	37	mutation	mutation	NOUN
dpc-571	122	38	,	,	PUNCT
dpc-571	122	39	such	such	ADJ
dpc-571	122	40	as	as	ADP
dpc-571	122	41	young	young	ADJ
dpc-571	122	42	-	-	PUNCT
dpc-571	122	43	onset	onset	VERB
dpc-571	122	44	or	or	CCONJ
dpc-571	122	45	mpm	mpm	NOUN
dpc-571	122	46	patients	patient	NOUN
dpc-571	122	47	[	[	X
dpc-571	122	48	34	34	NUM
dpc-571	122	49	]	]	PUNCT
dpc-571	122	50	.	.	PUNCT
dpc-571	123	1	if	if	SCONJ
dpc-571	123	2	a	a	DET
dpc-571	123	3	cdkn2a	cdkn2a	PROPN
dpc-571	123	4	mutation	mutation	NOUN
dpc-571	123	5	is	be	AUX
dpc-571	123	6	detected	detect	VERB
dpc-571	123	7	in	in	ADP
dpc-571	123	8	a	a	DET
dpc-571	123	9	family	family	NOUN
dpc-571	123	10	,	,	PUNCT
dpc-571	123	11	screening	screen	VERB
dpc-571	123	12	of	of	ADP
dpc-571	123	13	other	other	ADJ
dpc-571	123	14	family	family	NOUN
dpc-571	123	15	members	member	NOUN
dpc-571	123	16	is	be	AUX
dpc-571	123	17	recommended	recommend	VERB
dpc-571	123	18	.	.	PUNCT
dpc-571	124	1	if	if	SCONJ
dpc-571	124	2	no	no	DET
dpc-571	124	3	cdkn2a	cdkn2a	PROPN
dpc-571	124	4	mutation	mutation	NOUN
dpc-571	124	5	is	be	AUX
dpc-571	124	6	identified	identify	VERB
dpc-571	124	7	within	within	ADP
dpc-571	124	8	a	a	DET
dpc-571	124	9	melanoma	melanoma	NOUN
dpc-571	124	10	family	family	NOUN
dpc-571	124	11	,	,	PUNCT
dpc-571	124	12	it	it	PRON
dpc-571	124	13	should	should	AUX
dpc-571	124	14	be	be	AUX
dpc-571	124	15	stressed	stress	VERB
dpc-571	124	16	that	that	SCONJ
dpc-571	124	17	the	the	DET
dpc-571	124	18	family	family	NOUN
dpc-571	124	19	is	be	AUX
dpc-571	124	20	still	still	ADV
dpc-571	124	21	at	at	ADP
dpc-571	124	22	increased	increase	VERB
dpc-571	124	23	risk	risk	NOUN
dpc-571	124	24	of	of	ADP
dpc-571	124	25	melanoma	melanoma	NOUN
dpc-571	124	26	on	on	ADP
dpc-571	124	27	the	the	DET
dpc-571	124	28	basis	basis	NOUN
dpc-571	124	29	of	of	ADP
dpc-571	124	30	the	the	DET
dpc-571	124	31	family	family	NOUN
dpc-571	124	32	history	history	NOUN
dpc-571	124	33	.	.	PUNCT
dpc-571	125	1	patients	patient	NOUN
dpc-571	125	2	should	should	AUX
dpc-571	125	3	be	be	AUX
dpc-571	125	4	aware	aware	ADJ
dpc-571	125	5	of	of	ADP
dpc-571	125	6	the	the	DET
dpc-571	125	7	difficulty	difficulty	NOUN
dpc-571	125	8	of	of	ADP
dpc-571	125	9	interprettable	interprettable	ADJ
dpc-571	125	10	2	2	NUM
dpc-571	125	11	.	.	PUNCT
dpc-571	125	12	selection	selection	NOUN
dpc-571	125	13	criteria	criterion	NOUN
dpc-571	125	14	for	for	ADP
dpc-571	125	15	cdkn2a	cdkn2a	PROPN
dpc-571	125	16	genetic	genetic	ADJ
dpc-571	125	17	testing	testing	NOUN
dpc-571	125	18	according	accord	VERB
dpc-571	125	19	to	to	ADP
dpc-571	125	20	melanoma	melanoma	ADJ
dpc-571	125	21	incidence	incidence	NOUN
dpc-571	125	22	[	[	X
dpc-571	125	23	31	31	NUM
dpc-571	125	24	]	]	X
dpc-571	125	25	geographic	geographic	ADJ
dpc-571	125	26	area	area	NOUN
dpc-571	125	27	/	/	SYM
dpc-571	125	28	population	population	NOUN
dpc-571	125	29	with	with	ADP
dpc-571	125	30	low	low	ADJ
dpc-571	125	31	melanoma	melanoma	NOUN
dpc-571	125	32	incidence	incidence	NOUN
dpc-571	125	33	geographic	geographic	ADJ
dpc-571	125	34	area	area	NOUN
dpc-571	125	35	/	/	SYM
dpc-571	125	36	population	population	NOUN
dpc-571	125	37	with	with	ADP
dpc-571	125	38	moderate	moderate	ADJ
dpc-571	125	39	–	–	PUNCT
dpc-571	125	40	high	high	ADJ
dpc-571	125	41	melanoma	melanoma	NOUN
dpc-571	125	42	incidence	incidence	NOUN
dpc-571	125	43	•	•	NOUN
dpc-571	125	44	two	two	NUM
dpc-571	125	45	(	(	PUNCT
dpc-571	125	46	synchronous	synchronous	ADJ
dpc-571	125	47	or	or	CCONJ
dpc-571	125	48	metachronous	metachronous	ADJ
dpc-571	125	49	)	)	PUNCT
dpc-571	125	50	primary	primary	ADJ
dpc-571	125	51	melanomas	melanomas	NOUN
dpc-571	125	52	in	in	ADP
dpc-571	125	53	an	an	DET
dpc-571	125	54	individual	individual	ADJ
dpc-571	125	55	and/or	and/or	CCONJ
dpc-571	125	56	•	•	ADJ
dpc-571	125	57	families	family	NOUN
dpc-571	125	58	with	with	ADP
dpc-571	125	59	the	the	DET
dpc-571	125	60	following	follow	VERB
dpc-571	125	61	clinical	clinical	ADJ
dpc-571	125	62	features	feature	NOUN
dpc-571	125	63	in	in	ADP
dpc-571	125	64	firstor	firstor	NOUN
dpc-571	125	65	second	second	ADJ
dpc-571	125	66	-	-	PUNCT
dpc-571	125	67	degree	degree	NOUN
dpc-571	125	68	relatives	relative	NOUN
dpc-571	125	69	on	on	ADP
dpc-571	125	70	the	the	DET
dpc-571	125	71	same	same	ADJ
dpc-571	125	72	side	side	NOUN
dpc-571	125	73	of	of	ADP
dpc-571	125	74	the	the	DET
dpc-571	125	75	family	family	NOUN
dpc-571	125	76	:	:	PUNCT
dpc-571	125	77	—	—	PUNCT
dpc-571	125	78	two	two	NUM
dpc-571	125	79	cases	case	NOUN
dpc-571	125	80	of	of	ADP
dpc-571	125	81	melanoma	melanoma	NOUN
dpc-571	125	82	(	(	PUNCT
dpc-571	125	83	one	one	NUM
dpc-571	125	84	invasive	invasive	ADJ
dpc-571	125	85	)	)	PUNCT
dpc-571	125	86	or	or	CCONJ
dpc-571	125	87	—	—	PUNCT
dpc-571	125	88	one	one	NUM
dpc-571	125	89	case	case	NOUN
dpc-571	125	90	of	of	ADP
dpc-571	125	91	melanoma	melanoma	NOUN
dpc-571	125	92	and	and	CCONJ
dpc-571	125	93	one	one	NUM
dpc-571	125	94	case	case	NOUN
dpc-571	125	95	of	of	ADP
dpc-571	125	96	pancreatic	pancreatic	ADJ
dpc-571	125	97	cancer	cancer	NOUN
dpc-571	125	98	•	•	NUM
dpc-571	125	99	three	three	NUM
dpc-571	125	100	primary	primary	ADJ
dpc-571	125	101	melanomas	melanomas	NOUN
dpc-571	125	102	in	in	ADP
dpc-571	125	103	an	an	DET
dpc-571	125	104	individual	individual	ADJ
dpc-571	125	105	and/or	and/or	CCONJ
dpc-571	125	106	•	•	ADJ
dpc-571	125	107	families	family	NOUN
dpc-571	125	108	with	with	ADP
dpc-571	125	109	the	the	DET
dpc-571	125	110	following	follow	VERB
dpc-571	125	111	clinical	clinical	ADJ
dpc-571	125	112	features	feature	NOUN
dpc-571	125	113	in	in	ADP
dpc-571	125	114	firstor	firstor	NOUN
dpc-571	125	115	second	second	ADJ
dpc-571	125	116	-	-	PUNCT
dpc-571	125	117	degree	degree	NOUN
dpc-571	125	118	relatives	relative	NOUN
dpc-571	125	119	on	on	ADP
dpc-571	125	120	the	the	DET
dpc-571	125	121	same	same	ADJ
dpc-571	125	122	side	side	NOUN
dpc-571	125	123	of	of	ADP
dpc-571	125	124	the	the	DET
dpc-571	125	125	family	family	NOUN
dpc-571	125	126	:	:	PUNCT
dpc-571	125	127	—	—	PUNCT
dpc-571	125	128	three	three	NUM
dpc-571	125	129	cases	case	NOUN
dpc-571	125	130	of	of	ADP
dpc-571	125	131	melanoma	melanoma	NOUN
dpc-571	125	132	(	(	PUNCT
dpc-571	125	133	one	one	NUM
dpc-571	125	134	invasive	invasive	ADJ
dpc-571	125	135	)	)	PUNCT
dpc-571	125	136	or	or	CCONJ
dpc-571	125	137	—	—	PUNCT
dpc-571	125	138	two	two	NUM
dpc-571	125	139	cases	case	NOUN
dpc-571	125	140	of	of	ADP
dpc-571	125	141	melanoma	melanoma	NOUN
dpc-571	125	142	and	and	CCONJ
dpc-571	125	143	one	one	NUM
dpc-571	125	144	case	case	NOUN
dpc-571	125	145	of	of	ADP
dpc-571	125	146	pancreatic	pancreatic	ADJ
dpc-571	125	147	cancer	cancer	NOUN
dpc-571	125	148	or	or	CCONJ
dpc-571	125	149	—	—	PUNCT
dpc-571	125	150	one	one	NUM
dpc-571	125	151	case	case	NOUN
dpc-571	125	152	of	of	ADP
dpc-571	125	153	melanoma	melanoma	NOUN
dpc-571	125	154	and	and	CCONJ
dpc-571	125	155	two	two	NUM
dpc-571	125	156	cases	case	NOUN
dpc-571	125	157	of	of	ADP
dpc-571	125	158	pancreatic	pancreatic	ADJ
dpc-571	125	159	cancer	cancer	NOUN
dpc-571	125	160	review	review	NOUN
dpc-571	125	161	|	|	ADV
dpc-571	125	162	dermatol	dermatol	ADJ
dpc-571	125	163	pract	pract	NOUN
dpc-571	125	164	concept	concept	NOUN
dpc-571	125	165	2019;9(1):3	2019;9(1):3	PROPN
dpc-571	125	166	15	15	NUM
dpc-571	125	167	15	15	NUM
dpc-571	125	168	.	.	PUNCT
dpc-571	126	1	pellegrini	pellegrini	PROPN
dpc-571	126	2	c	c	PROPN
dpc-571	126	3	,	,	PUNCT
dpc-571	126	4	maturo	maturo	PROPN
dpc-571	126	5	mg	mg	PROPN
dpc-571	126	6	,	,	PUNCT
dpc-571	126	7	martorelli	martorelli	NOUN
dpc-571	126	8	c	c	X
dpc-571	126	9	,	,	PUNCT
dpc-571	126	10	et	et	PROPN
dpc-571	126	11	 	 	SPACE
dpc-571	126	12	al	al	PROPN
dpc-571	126	13	.	.	PROPN
dpc-571	126	14	characterization	characterization	NOUN
dpc-571	126	15	of	of	ADP
dpc-571	126	16	melanoma	melanoma	NOUN
dpc-571	126	17	susceptibility	susceptibility	NOUN
dpc-571	126	18	genes	gene	NOUN
dpc-571	126	19	in	in	ADP
dpc-571	126	20	high	high	ADJ
dpc-571	126	21	-	-	PUNCT
dpc-571	126	22	risk	risk	NOUN
dpc-571	126	23	patients	patient	NOUN
dpc-571	126	24	from	from	ADP
dpc-571	126	25	central	central	PROPN
dpc-571	126	26	italy	italy	PROPN
dpc-571	126	27	.	.	PUNCT
dpc-571	127	1	melanoma	melanoma	NOUN
dpc-571	127	2	res	re	NOUN
dpc-571	127	3	.	.	PUNCT
dpc-571	128	1	2017;27(3):258	2017;27(3):258	PROPN
dpc-571	128	2	-	-	PUNCT
dpc-571	128	3	267	267	NUM
dpc-571	128	4	.	.	PUNCT
dpc-571	128	5	16	16	NUM
dpc-571	128	6	.	.	PUNCT
dpc-571	129	1	zuo	zuo	PROPN
dpc-571	129	2	l	l	PROPN
dpc-571	129	3	,	,	PUNCT
dpc-571	129	4	weger	weger	PROPN
dpc-571	129	5	j	j	PROPN
dpc-571	129	6	,	,	PUNCT
dpc-571	129	7	yang	yang	PROPN
dpc-571	129	8	q	q	PROPN
dpc-571	129	9	,	,	PUNCT
dpc-571	129	10	et	et	PROPN
dpc-571	129	11	 	 	SPACE
dpc-571	129	12	al	al	PROPN
dpc-571	129	13	.	.	PROPN
dpc-571	129	14	germline	germline	NOUN
dpc-571	129	15	mutations	mutation	NOUN
dpc-571	129	16	in	in	ADP
dpc-571	129	17	the	the	DET
dpc-571	129	18	p16ink4a	p16ink4a	NOUN
dpc-571	129	19	binding	bind	VERB
dpc-571	129	20	domain	domain	NOUN
dpc-571	129	21	of	of	ADP
dpc-571	129	22	cdk4	cdk4	NOUN
dpc-571	129	23	in	in	ADP
dpc-571	129	24	familial	familial	ADJ
dpc-571	129	25	melanoma	melanoma	NOUN
dpc-571	129	26	.	.	PUNCT
dpc-571	130	1	nat	nat	PROPN
dpc-571	130	2	genet	genet	PROPN
dpc-571	130	3	.	.	PUNCT
dpc-571	131	1	1996;12(1):97	1996;12(1):97	NUM
dpc-571	131	2	-	-	SYM
dpc-571	131	3	99	99	NUM
dpc-571	131	4	.	.	PUNCT
dpc-571	132	1	17	17	NUM
dpc-571	132	2	.	.	PUNCT
dpc-571	133	1	puntervoll	puntervoll	PROPN
dpc-571	133	2	he	he	PRON
dpc-571	133	3	,	,	PUNCT
dpc-571	133	4	yang	yang	PROPN
dpc-571	133	5	xr	xr	PROPN
dpc-571	133	6	,	,	PUNCT
dpc-571	133	7	vetti	vetti	NOUN
dpc-571	133	8	hh	hh	PROPN
dpc-571	133	9	,	,	PUNCT
dpc-571	133	10	et	et	NOUN
dpc-571	133	11	 	 	SPACE
dpc-571	134	1	al	al	PROPN
dpc-571	134	2	.	.	PUNCT
dpc-571	134	3	melanoma	melanoma	PROPN
dpc-571	134	4	prone	prone	ADJ
dpc-571	134	5	families	family	NOUN
dpc-571	134	6	with	with	ADP
dpc-571	134	7	cdk4	cdk4	NOUN
dpc-571	134	8	germline	germline	NOUN
dpc-571	134	9	mutation	mutation	NOUN
dpc-571	134	10	:	:	PUNCT
dpc-571	134	11	phenotypic	phenotypic	ADJ
dpc-571	134	12	profile	profile	NOUN
dpc-571	134	13	and	and	CCONJ
dpc-571	134	14	associations	association	NOUN
dpc-571	134	15	with	with	ADP
dpc-571	134	16	mc1r	mc1r	PROPN
dpc-571	134	17	variants	variant	NOUN
dpc-571	134	18	.	.	PUNCT
dpc-571	135	1	j	j	PROPN
dpc-571	135	2	med	med	PROPN
dpc-571	135	3	genet	genet	PROPN
dpc-571	135	4	.	.	PUNCT
dpc-571	136	1	2013;50(4):264	2013;50(4):264	NUM
dpc-571	136	2	-	-	SYM
dpc-571	136	3	270	270	NUM
dpc-571	136	4	.	.	NOUN
dpc-571	136	5	18	18	NUM
dpc-571	136	6	.	.	PUNCT
dpc-571	137	1	horn	horn	PROPN
dpc-571	137	2	s	s	PROPN
dpc-571	137	3	,	,	PUNCT
dpc-571	137	4	figl	figl	VERB
dpc-571	137	5	a	a	DET
dpc-571	137	6	,	,	PUNCT
dpc-571	137	7	rachakonda	rachakonda	ADJ
dpc-571	137	8	ps	ps	PROPN
dpc-571	137	9	,	,	PUNCT
dpc-571	137	10	et	et	PROPN
dpc-571	137	11	 	 	SPACE
dpc-571	137	12	al	al	PROPN
dpc-571	137	13	.	.	PUNCT
dpc-571	137	14	tert	tert	NOUN
dpc-571	137	15	promoter	promoter	NOUN
dpc-571	137	16	mutations	mutation	NOUN
dpc-571	137	17	in	in	ADP
dpc-571	137	18	familial	familial	ADJ
dpc-571	137	19	and	and	CCONJ
dpc-571	137	20	sporadic	sporadic	ADJ
dpc-571	137	21	melanoma	melanoma	NOUN
dpc-571	137	22	.	.	PUNCT
dpc-571	138	1	science	science	NOUN
dpc-571	138	2	.	.	PUNCT
dpc-571	139	1	2013;339(6122):959961	2013;339(6122):959961	NUM
dpc-571	139	2	.	.	NOUN
dpc-571	140	1	19	19	NUM
dpc-571	140	2	.	.	PUNCT
dpc-571	141	1	harland	harland	PROPN
dpc-571	141	2	m	m	PROPN
dpc-571	141	3	,	,	PUNCT
dpc-571	141	4	petljak	petljak	PROPN
dpc-571	141	5	m	m	PROPN
dpc-571	141	6	,	,	PUNCT
dpc-571	141	7	robles	robles	PROPN
dpc-571	141	8	-	-	PUNCT
dpc-571	141	9	espinoza	espinoza	PROPN
dpc-571	141	10	cd	cd	PROPN
dpc-571	141	11	,	,	PUNCT
dpc-571	141	12	et	et	PROPN
dpc-571	141	13	 	 	SPACE
dpc-571	141	14	al	al	PROPN
dpc-571	141	15	.	.	PROPN
dpc-571	141	16	germline	germline	NOUN
dpc-571	141	17	tert	tert	NOUN
dpc-571	141	18	promoter	promoter	NOUN
dpc-571	141	19	mutations	mutation	NOUN
dpc-571	141	20	are	be	AUX
dpc-571	141	21	rare	rare	ADJ
dpc-571	141	22	in	in	ADP
dpc-571	141	23	familial	familial	ADJ
dpc-571	141	24	melanoma	melanoma	NOUN
dpc-571	141	25	.	.	PUNCT
dpc-571	142	1	fam	fam	NOUN
dpc-571	142	2	cancer	cancer	NOUN
dpc-571	142	3	.	.	PUNCT
dpc-571	143	1	2016;15(1):139	2016;15(1):139	NUM
dpc-571	143	2	-	-	SYM
dpc-571	143	3	144	144	NUM
dpc-571	143	4	.	.	NOUN
dpc-571	143	5	20	20	NUM
dpc-571	143	6	.	.	PUNCT
dpc-571	144	1	robles	robles	PROPN
dpc-571	144	2	-	-	PUNCT
dpc-571	144	3	espinoza	espinoza	PROPN
dpc-571	144	4	cd	cd	PROPN
dpc-571	144	5	,	,	PUNCT
dpc-571	144	6	harland	harland	PROPN
dpc-571	144	7	m	m	PROPN
dpc-571	144	8	,	,	PUNCT
dpc-571	144	9	ramsay	ramsay	PROPN
dpc-571	144	10	aj	aj	PROPN
dpc-571	144	11	,	,	PUNCT
dpc-571	144	12	et	et	PROPN
dpc-571	144	13	 	 	SPACE
dpc-571	144	14	al	al	PROPN
dpc-571	144	15	.	.	PROPN
dpc-571	145	1	pot1	pot1	PROPN
dpc-571	145	2	lossof	lossof	PROPN
dpc-571	145	3	-	-	PUNCT
dpc-571	145	4	function	function	NOUN
dpc-571	145	5	variants	variant	NOUN
dpc-571	145	6	predispose	predispose	VERB
dpc-571	145	7	to	to	ADP
dpc-571	145	8	familial	familial	ADJ
dpc-571	145	9	melanoma	melanoma	NOUN
dpc-571	145	10	.	.	PUNCT
dpc-571	146	1	nat	nat	PROPN
dpc-571	146	2	genet	genet	PROPN
dpc-571	146	3	.	.	PUNCT
dpc-571	147	1	2014;46(5):478	2014;46(5):478	PROPN
dpc-571	147	2	-	-	PUNCT
dpc-571	147	3	481	481	NUM
dpc-571	147	4	.	.	PUNCT
dpc-571	148	1	21	21	NUM
dpc-571	148	2	.	.	PUNCT
dpc-571	149	1	shi	shi	PROPN
dpc-571	149	2	j	j	PROPN
dpc-571	149	3	,	,	PUNCT
dpc-571	149	4	yang	yang	PROPN
dpc-571	149	5	xr	xr	PROPN
dpc-571	149	6	,	,	PUNCT
dpc-571	149	7	ballew	ballew	PROPN
dpc-571	149	8	b	b	PROPN
dpc-571	149	9	,	,	PUNCT
dpc-571	149	10	et	et	PROPN
dpc-571	149	11	 	 	SPACE
dpc-571	149	12	al	al	PROPN
dpc-571	149	13	.	.	PROPN
dpc-571	149	14	rare	rare	ADJ
dpc-571	149	15	missense	missense	NOUN
dpc-571	149	16	variants	variant	NOUN
dpc-571	149	17	in	in	ADP
dpc-571	149	18	pot1	pot1	PROPN
dpc-571	149	19	predispose	predispose	VERB
dpc-571	149	20	to	to	ADP
dpc-571	149	21	familial	familial	ADJ
dpc-571	149	22	cutaneous	cutaneous	ADJ
dpc-571	149	23	malignant	malignant	ADJ
dpc-571	149	24	melanoma	melanoma	NOUN
dpc-571	149	25	.	.	PUNCT
dpc-571	150	1	nat	nat	PROPN
dpc-571	150	2	genet	genet	PROPN
dpc-571	150	3	.	.	PUNCT
dpc-571	151	1	2014;46(5):482	2014;46(5):482	NUM
dpc-571	151	2	-	-	SYM
dpc-571	151	3	486	486	NUM
dpc-571	151	4	.	.	PUNCT
dpc-571	152	1	22	22	NUM
dpc-571	152	2	.	.	PUNCT
dpc-571	153	1	müller	müller	PROPN
dpc-571	153	2	c	c	PROPN
dpc-571	153	3	,	,	PUNCT
dpc-571	153	4	krunic	krunic	PROPN
dpc-571	153	5	m	m	PROPN
dpc-571	153	6	,	,	PUNCT
dpc-571	153	7	wendt	wendt	PROPN
dpc-571	153	8	j	j	PROPN
dpc-571	153	9	,	,	PUNCT
dpc-571	153	10	von	von	PROPN
dpc-571	153	11	haeseler	haeseler	PROPN
dpc-571	153	12	a	a	PROPN
dpc-571	153	13	,	,	PUNCT
dpc-571	153	14	okamoto	okamoto	PROPN
dpc-571	153	15	i.	i.	PROPN
dpc-571	153	16	germline	germline	PROPN
dpc-571	153	17	variants	variant	NOUN
dpc-571	153	18	in	in	ADP
dpc-571	153	19	the	the	DET
dpc-571	153	20	pot1	pot1	PROPN
dpc-571	153	21	-	-	PUNCT
dpc-571	153	22	gene	gene	PROPN
dpc-571	153	23	in	in	ADP
dpc-571	153	24	high	high	ADJ
dpc-571	153	25	-	-	PUNCT
dpc-571	153	26	risk	risk	NOUN
dpc-571	153	27	melanoma	melanoma	NOUN
dpc-571	153	28	patients	patient	NOUN
dpc-571	153	29	in	in	ADP
dpc-571	153	30	austria	austria	PROPN
dpc-571	153	31	.	.	PUNCT
dpc-571	154	1	g3	g3	PROPN
dpc-571	154	2	(	(	PUNCT
dpc-571	154	3	bethesda	bethesda	NOUN
dpc-571	154	4	)	)	PUNCT
dpc-571	154	5	.	.	PUNCT
dpc-571	155	1	2018;8(5):1475	2018;8(5):1475	NUM
dpc-571	155	2	-	-	SYM
dpc-571	155	3	1480	1480	NUM
dpc-571	155	4	.	.	PUNCT
dpc-571	156	1	23	23	NUM
dpc-571	156	2	.	.	PUNCT
dpc-571	157	1	pasquali	pasquali	PROPN
dpc-571	157	2	e	e	NOUN
dpc-571	157	3	,	,	PUNCT
dpc-571	157	4	garcía	garcía	ADJ
dpc-571	157	5	-	-	PUNCT
dpc-571	157	6	borrón	borrón	PROPN
dpc-571	157	7	jc	jc	PROPN
dpc-571	157	8	,	,	PUNCT
dpc-571	157	9	fargnoli	fargnoli	PROPN
dpc-571	157	10	mc	mc	PROPN
dpc-571	157	11	,	,	PUNCT
dpc-571	157	12	et	et	PROPN
dpc-571	157	13	 	 	SPACE
dpc-571	157	14	al	al	PROPN
dpc-571	157	15	.	.	PROPN
dpc-571	158	1	mc1r	mc1r	PROPN
dpc-571	158	2	variants	variant	NOUN
dpc-571	158	3	increased	increase	VERB
dpc-571	158	4	the	the	DET
dpc-571	158	5	risk	risk	NOUN
dpc-571	158	6	of	of	ADP
dpc-571	158	7	sporadic	sporadic	ADJ
dpc-571	158	8	cutaneous	cutaneous	ADJ
dpc-571	158	9	melanoma	melanoma	NOUN
dpc-571	158	10	in	in	ADP
dpc-571	158	11	darker	darker	ADV
dpc-571	158	12	-	-	PUNCT
dpc-571	158	13	pigmented	pigment	VERB
dpc-571	158	14	caucasians	caucasian	NOUN
dpc-571	158	15	:	:	PUNCT
dpc-571	158	16	a	a	DET
dpc-571	158	17	pooled	pool	VERB
dpc-571	158	18	-	-	PUNCT
dpc-571	158	19	analysis	analysis	NOUN
dpc-571	158	20	from	from	ADP
dpc-571	158	21	the	the	DET
dpc-571	158	22	m	m	NOUN
dpc-571	158	23	-	-	PUNCT
dpc-571	158	24	skip	skip	ADJ
dpc-571	158	25	project	project	NOUN
dpc-571	158	26	.	.	PUNCT
dpc-571	159	1	int	int	NOUN
dpc-571	159	2	j	j	PROPN
dpc-571	159	3	cancer	cancer	NOUN
dpc-571	159	4	.	.	PUNCT
dpc-571	160	1	2015;136(3):618	2015;136(3):618	NUM
dpc-571	160	2	-	-	PUNCT
dpc-571	160	3	631	631	NUM
dpc-571	160	4	.	.	PUNCT
dpc-571	161	1	24	24	NUM
dpc-571	161	2	.	.	PUNCT
dpc-571	162	1	fargnoli	fargnoli	PROPN
dpc-571	162	2	mc	mc	PROPN
dpc-571	162	3	,	,	PUNCT
dpc-571	162	4	gandini	gandini	VERB
dpc-571	162	5	s	s	PROPN
dpc-571	162	6	,	,	PUNCT
dpc-571	162	7	peris	peris	PROPN
dpc-571	162	8	k	k	PROPN
dpc-571	162	9	,	,	PUNCT
dpc-571	162	10	et	et	PROPN
dpc-571	162	11	 	 	SPACE
dpc-571	162	12	al	al	PROPN
dpc-571	162	13	.	.	PROPN
dpc-571	163	1	mc1r	mc1r	PROPN
dpc-571	163	2	variants	variant	NOUN
dpc-571	163	3	increase	increase	VERB
dpc-571	163	4	melanoma	melanoma	ADJ
dpc-571	163	5	risk	risk	NOUN
dpc-571	163	6	in	in	ADP
dpc-571	163	7	families	family	NOUN
dpc-571	163	8	with	with	ADP
dpc-571	163	9	cdkn2a	cdkn2a	PROPN
dpc-571	163	10	mutations	mutation	NOUN
dpc-571	163	11	:	:	PUNCT
dpc-571	163	12	a	a	DET
dpc-571	163	13	metaanalysis	metaanalysis	NOUN
dpc-571	163	14	.	.	PUNCT
dpc-571	164	1	eur	eur	PROPN
dpc-571	164	2	j	j	PROPN
dpc-571	164	3	cancer	cancer	NOUN
dpc-571	164	4	.	.	PUNCT
dpc-571	165	1	2010;46(8):1413	2010;46(8):1413	PROPN
dpc-571	165	2	-	-	SYM
dpc-571	165	3	1420	1420	NUM
dpc-571	165	4	.	.	PUNCT
dpc-571	166	1	25	25	NUM
dpc-571	166	2	.	.	PUNCT
dpc-571	167	1	yokoyama	yokoyama	PROPN
dpc-571	167	2	s	s	PROPN
dpc-571	167	3	,	,	PUNCT
dpc-571	167	4	woods	woods	PROPN
dpc-571	167	5	sl	sl	PROPN
dpc-571	167	6	,	,	PUNCT
dpc-571	167	7	boyle	boyle	PROPN
dpc-571	167	8	gm	gm	PROPN
dpc-571	167	9	,	,	PUNCT
dpc-571	167	10	et	et	PROPN
dpc-571	167	11	 	 	SPACE
dpc-571	167	12	al	al	PROPN
dpc-571	167	13	.	.	PUNCT
dpc-571	168	1	a	a	DET
dpc-571	168	2	novel	novel	ADJ
dpc-571	168	3	recurrent	recurrent	ADJ
dpc-571	168	4	mutation	mutation	NOUN
dpc-571	168	5	in	in	ADP
dpc-571	168	6	mitf	mitf	ADJ
dpc-571	168	7	predisposes	predispose	NOUN
dpc-571	168	8	to	to	ADP
dpc-571	168	9	familial	familial	ADJ
dpc-571	168	10	and	and	CCONJ
dpc-571	168	11	sporadic	sporadic	ADJ
dpc-571	168	12	melanoma	melanoma	NOUN
dpc-571	168	13	.	.	PUNCT
dpc-571	169	1	nature	nature	NOUN
dpc-571	169	2	.	.	PUNCT
dpc-571	170	1	2011;480(7375):99	2011;480(7375):99	NUM
dpc-571	170	2	-	-	PUNCT
dpc-571	170	3	103	103	NUM
dpc-571	170	4	.	.	PUNCT
dpc-571	171	1	26	26	NUM
dpc-571	171	2	.	.	PUNCT
dpc-571	172	1	bertolotto	bertolotto	PROPN
dpc-571	172	2	c	c	X
dpc-571	172	3	,	,	PUNCT
dpc-571	172	4	lesueur	lesueur	ADV
dpc-571	172	5	f	f	X
dpc-571	172	6	,	,	PUNCT
dpc-571	172	7	giuliano	giuliano	PROPN
dpc-571	172	8	s	s	PROPN
dpc-571	172	9	,	,	PUNCT
dpc-571	172	10	et	et	PROPN
dpc-571	172	11	 	 	SPACE
dpc-571	172	12	al	al	PROPN
dpc-571	172	13	.	.	PUNCT
dpc-571	173	1	a	a	DET
dpc-571	173	2	sumoylationdefective	sumoylationdefective	ADJ
dpc-571	173	3	mitf	mitf	NOUN
dpc-571	173	4	germline	germline	NOUN
dpc-571	173	5	mutation	mutation	NOUN
dpc-571	173	6	predisposes	predispose	NOUN
dpc-571	173	7	to	to	ADP
dpc-571	173	8	melanoma	melanoma	NOUN
dpc-571	173	9	and	and	CCONJ
dpc-571	173	10	renal	renal	ADJ
dpc-571	173	11	carcinoma	carcinoma	NOUN
dpc-571	173	12	.	.	PUNCT
dpc-571	174	1	nature	nature	NOUN
dpc-571	174	2	.	.	PUNCT
dpc-571	175	1	2011;480(7375):94	2011;480(7375):94	NUM
dpc-571	175	2	-	-	SYM
dpc-571	175	3	98	98	NUM
dpc-571	175	4	.	.	PUNCT
dpc-571	176	1	27	27	NUM
dpc-571	176	2	.	.	PUNCT
dpc-571	177	1	begg	begg	PROPN
dpc-571	177	2	c	c	PROPN
dpc-571	177	3	,	,	PUNCT
dpc-571	177	4	orlow	orlow	ADJ
dpc-571	177	5	i	i	PRON
dpc-571	177	6	,	,	PUNCT
dpc-571	177	7	hummer	hummer	PROPN
dpc-571	177	8	a	a	PROPN
dpc-571	177	9	,	,	PUNCT
dpc-571	177	10	et	et	PROPN
dpc-571	177	11	 	 	SPACE
dpc-571	177	12	al	al	PROPN
dpc-571	177	13	.	.	PROPN
dpc-571	177	14	lifetime	lifetime	NOUN
dpc-571	177	15	risk	risk	NOUN
dpc-571	177	16	of	of	ADP
dpc-571	177	17	melanoma	melanoma	NOUN
dpc-571	177	18	in	in	ADP
dpc-571	177	19	cdkn2a	cdkn2a	PROPN
dpc-571	177	20	mutation	mutation	NOUN
dpc-571	177	21	carriers	carrier	NOUN
dpc-571	177	22	in	in	ADP
dpc-571	177	23	a	a	DET
dpc-571	177	24	population	population	NOUN
dpc-571	177	25	-	-	PUNCT
dpc-571	177	26	based	base	VERB
dpc-571	177	27	sample	sample	NOUN
dpc-571	177	28	.	.	PUNCT
dpc-571	178	1	j	j	PROPN
dpc-571	178	2	natl	natl	PROPN
dpc-571	178	3	cancer	cancer	PROPN
dpc-571	178	4	inst	inst	PROPN
dpc-571	178	5	.	.	PUNCT
dpc-571	179	1	2005;97(20):1507–1515	2005;97(20):1507–1515	NOUN
dpc-571	179	2	.	.	PUNCT
dpc-571	180	1	28	28	NUM
dpc-571	180	2	.	.	PUNCT
dpc-571	181	1	bruno	bruno	PROPN
dpc-571	181	2	w	w	PROPN
dpc-571	181	3	,	,	PUNCT
dpc-571	181	4	ghiorzo	ghiorzo	NOUN
dpc-571	181	5	p	p	NOUN
dpc-571	181	6	,	,	PUNCT
dpc-571	181	7	battistuzzi	battistuzzi	NOUN
dpc-571	181	8	l	l	PROPN
dpc-571	181	9	,	,	PUNCT
dpc-571	181	10	et	et	PROPN
dpc-571	181	11	 	 	SPACE
dpc-571	181	12	al	al	PROPN
dpc-571	181	13	.	.	PROPN
dpc-571	181	14	clinical	clinical	ADJ
dpc-571	181	15	genetic	genetic	ADJ
dpc-571	181	16	testing	testing	NOUN
dpc-571	181	17	for	for	ADP
dpc-571	181	18	familial	familial	ADJ
dpc-571	181	19	melanoma	melanoma	NOUN
dpc-571	181	20	in	in	ADP
dpc-571	181	21	italy	italy	PROPN
dpc-571	181	22	:	:	PUNCT
dpc-571	181	23	a	a	DET
dpc-571	181	24	cooperative	cooperative	ADJ
dpc-571	181	25	study	study	NOUN
dpc-571	181	26	.	.	PUNCT
dpc-571	182	1	j	j	PROPN
dpc-571	182	2	am	be	AUX
dpc-571	182	3	acad	acad	ADJ
dpc-571	182	4	dermatol	dermatol	NOUN
dpc-571	182	5	.	.	PUNCT
dpc-571	183	1	2009;61(5):775	2009;61(5):775	NUM
dpc-571	183	2	-	-	PUNCT
dpc-571	183	3	782	782	NUM
dpc-571	183	4	.	.	PUNCT
dpc-571	183	5	29	29	NUM
dpc-571	183	6	.	.	PUNCT
dpc-571	184	1	maubec	maubec	PROPN
dpc-571	184	2	e	e	PROPN
dpc-571	184	3	,	,	PUNCT
dpc-571	184	4	chaudru	chaudru	NOUN
dpc-571	184	5	v	v	ADP
dpc-571	184	6	,	,	PUNCT
dpc-571	184	7	mohamdi	mohamdi	ADJ
dpc-571	184	8	h	h	NOUN
dpc-571	184	9	,	,	PUNCT
dpc-571	184	10	et	et	PROPN
dpc-571	184	11	 	 	SPACE
dpc-571	184	12	al	al	PROPN
dpc-571	184	13	.	.	PROPN
dpc-571	185	1	familial	familial	ADJ
dpc-571	185	2	melanoma	melanoma	NOUN
dpc-571	185	3	:	:	PUNCT
dpc-571	185	4	clinical	clinical	ADJ
dpc-571	185	5	factors	factor	NOUN
dpc-571	185	6	associated	associate	VERB
dpc-571	185	7	with	with	ADP
dpc-571	185	8	germline	germline	NOUN
dpc-571	185	9	cdkn2a	cdkn2a	PROPN
dpc-571	185	10	mutations	mutation	NOUN
dpc-571	185	11	according	accord	VERB
dpc-571	185	12	to	to	ADP
dpc-571	185	13	the	the	DET
dpc-571	185	14	number	number	NOUN
dpc-571	185	15	of	of	ADP
dpc-571	185	16	patients	patient	NOUN
dpc-571	185	17	affected	affect	VERB
dpc-571	185	18	by	by	ADP
dpc-571	185	19	melanoma	melanoma	NOUN
dpc-571	185	20	in	in	ADP
dpc-571	185	21	a	a	DET
dpc-571	185	22	family	family	NOUN
dpc-571	185	23	.	.	PUNCT
dpc-571	186	1	j	j	PROPN
dpc-571	186	2	am	be	AUX
dpc-571	186	3	acad	acad	ADJ
dpc-571	186	4	dermatol	dermatol	NOUN
dpc-571	186	5	.	.	PUNCT
dpc-571	187	1	2012;67(6):1257	2012;67(6):1257	NOUN
dpc-571	187	2	-	-	SYM
dpc-571	187	3	1264	1264	NUM
dpc-571	187	4	.	.	PUNCT
dpc-571	188	1	30	30	NUM
dpc-571	188	2	.	.	PUNCT
dpc-571	189	1	harland	harland	PROPN
dpc-571	189	2	m	m	PROPN
dpc-571	189	3	,	,	PUNCT
dpc-571	189	4	cust	cust	PROPN
dpc-571	189	5	ae	ae	PROPN
dpc-571	189	6	,	,	PUNCT
dpc-571	189	7	badenas	badenas	PROPN
dpc-571	190	1	c	c	AUX
dpc-571	190	2	,	,	PUNCT
dpc-571	190	3	et	et	PROPN
dpc-571	190	4	 	 	SPACE
dpc-571	190	5	al	al	PROPN
dpc-571	190	6	.	.	PUNCT
dpc-571	190	7	prevalence	prevalence	NOUN
dpc-571	190	8	and	and	CCONJ
dpc-571	190	9	predictors	predictor	NOUN
dpc-571	190	10	of	of	ADP
dpc-571	190	11	germline	germline	NOUN
dpc-571	190	12	cdkn2a	cdkn2a	PROPN
dpc-571	190	13	mutations	mutation	NOUN
dpc-571	190	14	for	for	ADP
dpc-571	190	15	melanoma	melanoma	NOUN
dpc-571	190	16	cases	case	NOUN
dpc-571	190	17	from	from	ADP
dpc-571	190	18	australia	australia	PROPN
dpc-571	190	19	,	,	PUNCT
dpc-571	190	20	spain	spain	PROPN
dpc-571	190	21	and	and	CCONJ
dpc-571	190	22	the	the	DET
dpc-571	190	23	united	united	ADJ
dpc-571	190	24	kingdom	kingdom	PROPN
dpc-571	190	25	.	.	PUNCT
dpc-571	191	1	hered	here	VERB
dpc-571	191	2	cancer	cancer	NOUN
dpc-571	191	3	clin	clin	PROPN
dpc-571	191	4	pract	pract	PROPN
dpc-571	191	5	.	.	PUNCT
dpc-571	192	1	2014;12(1):20	2014;12(1):20	X
dpc-571	192	2	.	.	PUNCT
dpc-571	193	1	31	31	NUM
dpc-571	193	2	.	.	PUNCT
dpc-571	194	1	leachman	leachman	PROPN
dpc-571	194	2	s	s	PROPN
dpc-571	194	3	,	,	PUNCT
dpc-571	194	4	carucci	carucci	PROPN
dpc-571	194	5	j	j	PROPN
dpc-571	194	6	,	,	PUNCT
dpc-571	194	7	kohlmann	kohlmann	PROPN
dpc-571	194	8	l	l	PROPN
dpc-571	194	9	,	,	PUNCT
dpc-571	194	10	et	et	PROPN
dpc-571	194	11	 	 	SPACE
dpc-571	194	12	al	al	PROPN
dpc-571	194	13	.	.	PROPN
dpc-571	194	14	selection	selection	NOUN
dpc-571	194	15	criteria	criterion	NOUN
dpc-571	194	16	for	for	ADP
dpc-571	194	17	genetic	genetic	ADJ
dpc-571	194	18	assessment	assessment	NOUN
dpc-571	194	19	of	of	ADP
dpc-571	194	20	patients	patient	NOUN
dpc-571	194	21	with	with	ADP
dpc-571	194	22	familial	familial	ADJ
dpc-571	194	23	melanoma	melanoma	NOUN
dpc-571	194	24	.	.	PUNCT
dpc-571	195	1	j	j	PROPN
dpc-571	195	2	am	be	AUX
dpc-571	195	3	acad	acad	ADJ
dpc-571	195	4	dermatol	dermatol	NOUN
dpc-571	195	5	.	.	PUNCT
dpc-571	196	1	2009;61(4):677.e1	2009;61(4):677.e1	NUM
dpc-571	196	2	-	-	SYM
dpc-571	196	3	14	14	NUM
dpc-571	196	4	.	.	PUNCT
dpc-571	197	1	32	32	NUM
dpc-571	197	2	.	.	PUNCT
dpc-571	198	1	lang	lang	PROPN
dpc-571	198	2	j	j	PROPN
dpc-571	198	3	,	,	PUNCT
dpc-571	198	4	boxer	boxer	PROPN
dpc-571	198	5	m	m	PROPN
dpc-571	198	6	,	,	PUNCT
dpc-571	198	7	mackie	mackie	PROPN
dpc-571	198	8	rm	rm	PROPN
dpc-571	198	9	.	.	PUNCT
dpc-571	199	1	cdkn2a	cdkn2a	PROPN
dpc-571	199	2	mutations	mutation	NOUN
dpc-571	199	3	in	in	ADP
dpc-571	199	4	scottish	scottish	ADJ
dpc-571	199	5	families	family	NOUN
dpc-571	199	6	with	with	ADP
dpc-571	199	7	cutaneous	cutaneous	ADJ
dpc-571	199	8	melanoma	melanoma	NOUN
dpc-571	199	9	:	:	PUNCT
dpc-571	199	10	results	result	NOUN
dpc-571	199	11	from	from	ADP
dpc-571	199	12	32	32	NUM
dpc-571	199	13	newly	newly	ADV
dpc-571	199	14	identified	identify	VERB
dpc-571	199	15	families	family	NOUN
dpc-571	199	16	.	.	PUNCT
dpc-571	200	1	br	br	PROPN
dpc-571	200	2	j	j	PROPN
dpc-571	200	3	dermatol	dermatol	NOUN
dpc-571	200	4	.	.	PUNCT
dpc-571	201	1	2005;153(6):1121	2005;153(6):1121	NUM
dpc-571	201	2	.	.	PUNCT
dpc-571	202	1	33	33	NUM
dpc-571	202	2	.	.	PUNCT
dpc-571	203	1	chudnovsky	chudnovsky	PROPN
dpc-571	203	2	y	y	PROPN
dpc-571	203	3	,	,	PUNCT
dpc-571	203	4	khavari	khavari	PROPN
dpc-571	203	5	pa	pa	PROPN
dpc-571	203	6	,	,	PUNCT
dpc-571	203	7	adams	adams	PROPN
dpc-571	203	8	ae	ae	PROPN
dpc-571	203	9	.	.	PUNCT
dpc-571	204	1	melanoma	melanoma	PROPN
dpc-571	204	2	genetics	genetic	NOUN
dpc-571	204	3	and	and	CCONJ
dpc-571	204	4	the	the	DET
dpc-571	204	5	development	development	NOUN
dpc-571	204	6	of	of	ADP
dpc-571	204	7	rational	rational	ADJ
dpc-571	204	8	therapeutics	therapeutic	NOUN
dpc-571	204	9	.	.	PUNCT
dpc-571	205	1	j	j	PROPN
dpc-571	205	2	clin	clin	PROPN
dpc-571	205	3	invest	invest	PROPN
dpc-571	205	4	.	.	PUNCT
dpc-571	206	1	2005;115(4):813	2005;115(4):813	NUM
dpc-571	206	2	-	-	SYM
dpc-571	206	3	824	824	NUM
dpc-571	206	4	.	.	PUNCT
dpc-571	207	1	pancreatic	pancreatic	ADJ
dpc-571	207	2	cancer	cancer	NOUN
dpc-571	207	3	screening	screening	NOUN
dpc-571	207	4	via	via	ADP
dpc-571	207	5	endoscopic	endoscopic	ADJ
dpc-571	207	6	ultrasonography	ultrasonography	NOUN
dpc-571	207	7	or	or	CCONJ
dpc-571	207	8	magnetic	magnetic	ADJ
dpc-571	207	9	resonance	resonance	NOUN
dpc-571	207	10	cholangiopancreatography	cholangiopancreatography	NOUN
dpc-571	207	11	.	.	PUNCT
dpc-571	208	1	the	the	DET
dpc-571	208	2	recommendation	recommendation	NOUN
dpc-571	208	3	of	of	ADP
dpc-571	208	4	avoiding	avoid	VERB
dpc-571	208	5	smoking	smoking	NOUN
dpc-571	208	6	in	in	ADP
dpc-571	208	7	cancer	cancer	NOUN
dpc-571	208	8	prevention	prevention	NOUN
dpc-571	208	9	programs	program	NOUN
dpc-571	208	10	has	have	AUX
dpc-571	208	11	been	be	AUX
dpc-571	208	12	recently	recently	ADV
dpc-571	208	13	suggested	suggest	VERB
dpc-571	208	14	for	for	ADP
dpc-571	208	15	cdkn2a	cdkn2a	PROPN
dpc-571	208	16	mutation	mutation	NOUN
dpc-571	208	17	carriers	carrier	NOUN
dpc-571	208	18	after	after	ADP
dpc-571	208	19	the	the	DET
dpc-571	208	20	description	description	NOUN
dpc-571	208	21	of	of	ADP
dpc-571	208	22	an	an	DET
dpc-571	208	23	increased	increase	VERB
dpc-571	208	24	prevalence	prevalence	NOUN
dpc-571	208	25	of	of	ADP
dpc-571	208	26	tobacco	tobacco	NOUN
dpc-571	208	27	-	-	PUNCT
dpc-571	208	28	associated	associate	VERB
dpc-571	208	29	cancers	cancer	NOUN
dpc-571	208	30	in	in	ADP
dpc-571	208	31	cdkn2a	cdkn2a	PROPN
dpc-571	208	32	-	-	PUNCT
dpc-571	208	33	mutated	mutate	VERB
dpc-571	208	34	families	family	NOUN
dpc-571	208	35	[	[	X
dpc-571	208	36	67	67	NUM
dpc-571	208	37	]	]	PUNCT
dpc-571	208	38	.	.	PUNCT
dpc-571	209	1	first	first	ADJ
dpc-571	209	2	-	-	PUNCT
dpc-571	209	3	degree	degree	NOUN
dpc-571	209	4	relatives	relative	NOUN
dpc-571	209	5	(	(	PUNCT
dpc-571	209	6	parents	parent	NOUN
dpc-571	209	7	,	,	PUNCT
dpc-571	209	8	siblings	sibling	NOUN
dpc-571	209	9	,	,	PUNCT
dpc-571	209	10	children	child	NOUN
dpc-571	209	11	)	)	PUNCT
dpc-571	209	12	will	will	AUX
dpc-571	209	13	have	have	VERB
dpc-571	209	14	a	a	DET
dpc-571	209	15	50	50	NUM
dpc-571	209	16	%	%	NOUN
dpc-571	209	17	chance	chance	NOUN
dpc-571	209	18	of	of	ADP
dpc-571	209	19	harboring	harbor	VERB
dpc-571	209	20	the	the	DET
dpc-571	209	21	same	same	ADJ
dpc-571	209	22	mutation	mutation	NOUN
dpc-571	209	23	and	and	CCONJ
dpc-571	209	24	risk	risk	NOUN
dpc-571	209	25	.	.	PUNCT
dpc-571	210	1	it	it	PRON
dpc-571	210	2	is	be	AUX
dpc-571	210	3	also	also	ADV
dpc-571	210	4	prudent	prudent	ADJ
dpc-571	210	5	for	for	SCONJ
dpc-571	210	6	children	child	NOUN
dpc-571	210	7	from	from	ADP
dpc-571	210	8	familial	familial	ADJ
dpc-571	210	9	melanoma	melanoma	NOUN
dpc-571	210	10	kindreds	kindred	NOUN
dpc-571	210	11	to	to	PART
dpc-571	210	12	undergo	undergo	VERB
dpc-571	210	13	routine	routine	ADJ
dpc-571	210	14	skin	skin	NOUN
dpc-571	210	15	examinations	examination	NOUN
dpc-571	210	16	beginning	begin	VERB
dpc-571	210	17	at	at	ADP
dpc-571	210	18	puberty	puberty	PROPN
dpc-571	210	19	.	.	PUNCT
dpc-571	211	1	increased	increase	VERB
dpc-571	211	2	skin	skin	NOUN
dpc-571	211	3	cancer	cancer	NOUN
dpc-571	211	4	screening	screening	NOUN
dpc-571	211	5	,	,	PUNCT
dpc-571	211	6	patients	patient	NOUN
dpc-571	211	7	’	'	PUNCT
dpc-571	211	8	skin	skin	NOUN
dpc-571	211	9	self	self	NOUN
dpc-571	211	10	-	-	PUNCT
dpc-571	211	11	examination	examination	NOUN
dpc-571	211	12	education	education	NOUN
dpc-571	211	13	,	,	PUNCT
dpc-571	211	14	and	and	CCONJ
dpc-571	211	15	surveillance	surveillance	NOUN
dpc-571	211	16	by	by	ADP
dpc-571	211	17	physicians	physician	NOUN
dpc-571	211	18	should	should	AUX
dpc-571	211	19	be	be	AUX
dpc-571	211	20	encouraged	encourage	VERB
dpc-571	211	21	in	in	ADP
dpc-571	211	22	all	all	DET
dpc-571	211	23	patients	patient	NOUN
dpc-571	211	24	and	and	CCONJ
dpc-571	211	25	relatives	relative	NOUN
dpc-571	211	26	,	,	PUNCT
dpc-571	211	27	irrespective	irrespective	ADV
dpc-571	211	28	of	of	ADP
dpc-571	211	29	mutation	mutation	NOUN
dpc-571	211	30	status	status	NOUN
dpc-571	211	31	,	,	PUNCT
dpc-571	211	32	for	for	ADP
dpc-571	211	33	early	early	ADJ
dpc-571	211	34	detection	detection	NOUN
dpc-571	211	35	of	of	ADP
dpc-571	211	36	melanoma	melanoma	NOUN
dpc-571	211	37	.	.	PUNCT
dpc-571	212	1	references	reference	NOUN
dpc-571	212	2	1	1	NUM
dpc-571	212	3	.	.	PUNCT
dpc-571	212	4	nikolaou	nikolaou	PROPN
dpc-571	212	5	v	v	PROPN
dpc-571	212	6	,	,	PUNCT
dpc-571	212	7	stratigos	stratigos	PROPN
dpc-571	212	8	aj	aj	PROPN
dpc-571	212	9	.	.	PUNCT
dpc-571	213	1	emerging	emerge	VERB
dpc-571	213	2	trends	trend	NOUN
dpc-571	213	3	in	in	ADP
dpc-571	213	4	the	the	DET
dpc-571	213	5	epidemiology	epidemiology	NOUN
dpc-571	213	6	of	of	ADP
dpc-571	213	7	melanoma	melanoma	NOUN
dpc-571	213	8	.	.	PUNCT
dpc-571	214	1	br	br	PROPN
dpc-571	214	2	j	j	PROPN
dpc-571	214	3	dermatol	dermatol	NOUN
dpc-571	214	4	.	.	PUNCT
dpc-571	215	1	2014;170(1):11	2014;170(1):11	NUM
dpc-571	215	2	-	-	PUNCT
dpc-571	215	3	19	19	NUM
dpc-571	215	4	.	.	NOUN
dpc-571	215	5	2	2	NUM
dpc-571	215	6	.	.	PUNCT
dpc-571	216	1	balch	balch	PROPN
dpc-571	216	2	cm	cm	PROPN
dpc-571	216	3	,	,	PUNCT
dpc-571	216	4	buzaid	buzaid	VERB
dpc-571	216	5	ac	ac	PROPN
dpc-571	216	6	,	,	PUNCT
dpc-571	216	7	soong	soong	PROPN
dpc-571	216	8	sj	sj	PROPN
dpc-571	216	9	,	,	PUNCT
dpc-571	217	1	et	et	PROPN
dpc-571	217	2	 	 	SPACE
dpc-571	217	3	al	al	PROPN
dpc-571	217	4	.	.	PROPN
dpc-571	217	5	final	final	ADJ
dpc-571	217	6	version	version	NOUN
dpc-571	217	7	of	of	ADP
dpc-571	217	8	the	the	DET
dpc-571	217	9	american	american	PROPN
dpc-571	217	10	joint	joint	PROPN
dpc-571	217	11	committee	committee	PROPN
dpc-571	217	12	on	on	ADP
dpc-571	217	13	cancer	cancer	NOUN
dpc-571	217	14	staging	staging	NOUN
dpc-571	217	15	system	system	NOUN
dpc-571	217	16	for	for	ADP
dpc-571	217	17	cutaneous	cutaneous	ADJ
dpc-571	217	18	melanoma	melanoma	NOUN
dpc-571	217	19	.	.	PUNCT
dpc-571	218	1	j	j	PROPN
dpc-571	218	2	clin	clin	PROPN
dpc-571	218	3	oncol	oncol	PROPN
dpc-571	218	4	.	.	PUNCT
dpc-571	219	1	2001;19(16):3635–3648	2001;19(16):3635–3648	NOUN
dpc-571	219	2	.	.	PUNCT
dpc-571	220	1	3	3	X
dpc-571	220	2	.	.	X
dpc-571	220	3	gandini	gandini	PROPN
dpc-571	220	4	s	s	PROPN
dpc-571	220	5	,	,	PUNCT
dpc-571	220	6	sera	sera	NOUN
dpc-571	220	7	f	f	PROPN
dpc-571	220	8	,	,	PUNCT
dpc-571	220	9	cattaruzza	cattaruzza	PROPN
dpc-571	220	10	ms	ms	PROPN
dpc-571	220	11	,	,	PUNCT
dpc-571	220	12	et	et	PROPN
dpc-571	220	13	 	 	SPACE
dpc-571	220	14	al	al	PROPN
dpc-571	220	15	.	.	PUNCT
dpc-571	221	1	meta	meta	VERB
dpc-571	221	2	-	-	PUNCT
dpc-571	221	3	analysis	analysis	NOUN
dpc-571	221	4	of	of	ADP
dpc-571	221	5	risk	risk	NOUN
dpc-571	221	6	factors	factor	NOUN
dpc-571	221	7	for	for	ADP
dpc-571	221	8	cutaneous	cutaneous	ADJ
dpc-571	221	9	melanoma	melanoma	NOUN
dpc-571	221	10	,	,	PUNCT
dpc-571	221	11	i	i	PRON
dpc-571	221	12	:	:	PUNCT
dpc-571	221	13	common	common	ADJ
dpc-571	221	14	and	and	CCONJ
dpc-571	221	15	atypical	atypical	ADJ
dpc-571	221	16	naevi	naevi	NOUN
dpc-571	221	17	.	.	PUNCT
dpc-571	222	1	eur	eur	PROPN
dpc-571	222	2	j	j	PROPN
dpc-571	222	3	cancer	cancer	NOUN
dpc-571	222	4	.	.	PUNCT
dpc-571	223	1	2005;41(1)28	2005;41(1)28	NUM
dpc-571	223	2	-	-	SYM
dpc-571	223	3	44	44	NUM
dpc-571	223	4	.	.	PUNCT
dpc-571	224	1	4	4	NUM
dpc-571	224	2	.	.	X
dpc-571	224	3	gandini	gandini	PROPN
dpc-571	224	4	s	s	PROPN
dpc-571	224	5	,	,	PUNCT
dpc-571	224	6	sera	sera	NOUN
dpc-571	224	7	f	f	PROPN
dpc-571	224	8	,	,	PUNCT
dpc-571	224	9	cattaruzza	cattaruzza	PROPN
dpc-571	224	10	ms	ms	PROPN
dpc-571	224	11	,	,	PUNCT
dpc-571	224	12	et	et	PROPN
dpc-571	224	13	 	 	SPACE
dpc-571	224	14	al	al	PROPN
dpc-571	224	15	.	.	PUNCT
dpc-571	225	1	meta	meta	VERB
dpc-571	225	2	-	-	PUNCT
dpc-571	225	3	analysis	analysis	NOUN
dpc-571	225	4	of	of	ADP
dpc-571	225	5	risk	risk	NOUN
dpc-571	225	6	factors	factor	NOUN
dpc-571	225	7	for	for	ADP
dpc-571	225	8	cutaneous	cutaneous	ADJ
dpc-571	225	9	melanoma	melanoma	NOUN
dpc-571	225	10	,	,	PUNCT
dpc-571	225	11	ii	ii	PROPN
dpc-571	225	12	:	:	PUNCT
dpc-571	225	13	sun	sun	NOUN
dpc-571	225	14	exposure	exposure	NOUN
dpc-571	225	15	.	.	PUNCT
dpc-571	226	1	eur	eur	PROPN
dpc-571	226	2	j	j	PROPN
dpc-571	226	3	cancer	cancer	NOUN
dpc-571	226	4	.	.	PUNCT
dpc-571	227	1	2005;41(1):45	2005;41(1):45	NUM
dpc-571	227	2	-	-	SYM
dpc-571	227	3	60	60	NUM
dpc-571	227	4	.	.	PUNCT
dpc-571	228	1	5	5	NUM
dpc-571	228	2	.	.	X
dpc-571	228	3	gandini	gandini	PROPN
dpc-571	228	4	s	s	PROPN
dpc-571	228	5	,	,	PUNCT
dpc-571	228	6	sera	sera	NOUN
dpc-571	228	7	f	f	PROPN
dpc-571	228	8	,	,	PUNCT
dpc-571	228	9	cattaruzza	cattaruzza	PROPN
dpc-571	228	10	ms	ms	PROPN
dpc-571	228	11	,	,	PUNCT
dpc-571	228	12	et	et	PROPN
dpc-571	228	13	 	 	SPACE
dpc-571	228	14	al	al	PROPN
dpc-571	228	15	.	.	PUNCT
dpc-571	229	1	meta	meta	VERB
dpc-571	229	2	-	-	PUNCT
dpc-571	229	3	analysis	analysis	NOUN
dpc-571	229	4	of	of	ADP
dpc-571	229	5	risk	risk	NOUN
dpc-571	229	6	factors	factor	NOUN
dpc-571	229	7	for	for	ADP
dpc-571	229	8	cutaneous	cutaneous	ADJ
dpc-571	229	9	melanoma	melanoma	NOUN
dpc-571	229	10	,	,	PUNCT
dpc-571	229	11	iii	iii	X
dpc-571	229	12	:	:	PUNCT
dpc-571	229	13	family	family	NOUN
dpc-571	229	14	history	history	NOUN
dpc-571	229	15	,	,	PUNCT
dpc-571	229	16	actinic	actinic	ADJ
dpc-571	229	17	damage	damage	NOUN
dpc-571	229	18	and	and	CCONJ
dpc-571	229	19	phenotypic	phenotypic	ADJ
dpc-571	229	20	factors	factor	NOUN
dpc-571	229	21	.	.	PUNCT
dpc-571	230	1	eur	eur	PROPN
dpc-571	230	2	j	j	PROPN
dpc-571	230	3	cancer	cancer	NOUN
dpc-571	230	4	.	.	PUNCT
dpc-571	231	1	2005;41(14)2040	2005;41(14)2040	X
dpc-571	231	2	-	-	NOUN
dpc-571	231	3	2059	2059	NUM
dpc-571	231	4	.	.	PUNCT
dpc-571	232	1	6	6	NUM
dpc-571	232	2	.	.	X
dpc-571	232	3	goldstein	goldstein	PROPN
dpc-571	232	4	am	am	PROPN
dpc-571	232	5	.	.	PUNCT
dpc-571	233	1	familial	familial	ADJ
dpc-571	233	2	melanoma	melanoma	NOUN
dpc-571	233	3	,	,	PUNCT
dpc-571	233	4	pancreatic	pancreatic	ADJ
dpc-571	233	5	cancer	cancer	NOUN
dpc-571	233	6	and	and	CCONJ
dpc-571	233	7	germline	germline	NOUN
dpc-571	233	8	cdkn2a	cdkn2a	PROPN
dpc-571	233	9	mutations	mutation	NOUN
dpc-571	233	10	.	.	PUNCT
dpc-571	234	1	hum	hum	PROPN
dpc-571	234	2	mutat	mutat	PROPN
dpc-571	234	3	.	.	PUNCT
dpc-571	235	1	2004;23(6):630	2004;23(6):630	NOUN
dpc-571	235	2	.	.	PUNCT
dpc-571	236	1	7	7	X
dpc-571	236	2	.	.	X
dpc-571	236	3	psaty	psaty	PROPN
dpc-571	236	4	el	el	PROPN
dpc-571	236	5	,	,	PUNCT
dpc-571	236	6	scope	scope	VERB
dpc-571	236	7	a	a	PRON
dpc-571	236	8	,	,	PUNCT
dpc-571	236	9	halpern	halpern	PROPN
dpc-571	236	10	ac	ac	PROPN
dpc-571	236	11	,	,	PUNCT
dpc-571	236	12	marghoob	marghoob	NOUN
dpc-571	236	13	a.	a.	NOUN
dpc-571	236	14	defining	define	VERB
dpc-571	236	15	the	the	DET
dpc-571	236	16	patient	patient	NOUN
dpc-571	236	17	at	at	ADP
dpc-571	236	18	high	high	ADJ
dpc-571	236	19	risk	risk	NOUN
dpc-571	236	20	for	for	ADP
dpc-571	236	21	melanoma	melanoma	NOUN
dpc-571	236	22	.	.	PUNCT
dpc-571	237	1	int	int	NOUN
dpc-571	237	2	j	j	PROPN
dpc-571	237	3	dermatol	dermatol	NOUN
dpc-571	237	4	.	.	PUNCT
dpc-571	238	1	2010;49(4):362	2010;49(4):362	NUM
dpc-571	238	2	-	-	PUNCT
dpc-571	238	3	376	376	NUM
dpc-571	238	4	.	.	PUNCT
dpc-571	239	1	8	8	NUM
dpc-571	239	2	.	.	PUNCT
dpc-571	240	1	potrony	potrony	PROPN
dpc-571	240	2	m	m	PROPN
dpc-571	240	3	,	,	PUNCT
dpc-571	240	4	badenas	badena	NOUN
dpc-571	240	5	c	c	NOUN
dpc-571	240	6	,	,	PUNCT
dpc-571	240	7	aguilera	aguilera	PROPN
dpc-571	240	8	p	p	X
dpc-571	240	9	,	,	PUNCT
dpc-571	240	10	et	et	PROPN
dpc-571	240	11	 	 	SPACE
dpc-571	240	12	al	al	PROPN
dpc-571	240	13	.	.	PROPN
dpc-571	240	14	update	update	NOUN
dpc-571	240	15	in	in	ADP
dpc-571	240	16	genetic	genetic	ADJ
dpc-571	240	17	susceptibility	susceptibility	NOUN
dpc-571	240	18	in	in	ADP
dpc-571	240	19	melanoma	melanoma	NOUN
dpc-571	240	20	.	.	PUNCT
dpc-571	241	1	ann	ann	PROPN
dpc-571	241	2	transl	transl	PROPN
dpc-571	241	3	med	med	PROPN
dpc-571	241	4	.	.	PUNCT
dpc-571	242	1	2015;3(15):210	2015;3(15):210	NOUN
dpc-571	242	2	.	.	PUNCT
dpc-571	242	3	9	9	NUM
dpc-571	242	4	.	.	NOUN
dpc-571	242	5	aoude	aoude	NOUN
dpc-571	242	6	lg	lg	PROPN
dpc-571	242	7	,	,	PUNCT
dpc-571	242	8	wadt	wadt	PROPN
dpc-571	242	9	ka	ka	PROPN
dpc-571	242	10	,	,	PUNCT
dpc-571	242	11	pritchard	pritchard	PROPN
dpc-571	242	12	al	al	PROPN
dpc-571	242	13	,	,	PUNCT
dpc-571	242	14	hayward	hayward	PROPN
dpc-571	242	15	nk	nk	PROPN
dpc-571	242	16	.	.	PUNCT
dpc-571	243	1	genetics	genetic	NOUN
dpc-571	243	2	of	of	ADP
dpc-571	243	3	familial	familial	ADJ
dpc-571	243	4	melanoma	melanoma	NOUN
dpc-571	243	5	:	:	PUNCT
dpc-571	243	6	20	20	NUM
dpc-571	243	7	years	year	NOUN
dpc-571	243	8	after	after	ADP
dpc-571	243	9	cdkn2a	cdkn2a	PROPN
dpc-571	243	10	.	.	PUNCT
dpc-571	244	1	pigment	pigment	NOUN
dpc-571	244	2	cell	cell	NOUN
dpc-571	244	3	melanoma	melanoma	NOUN
dpc-571	244	4	res	re	NOUN
dpc-571	244	5	.	.	PUNCT
dpc-571	245	1	2015;28(2):148	2015;28(2):148	NUM
dpc-571	245	2	-	-	SYM
dpc-571	245	3	160	160	NUM
dpc-571	245	4	.	.	PUNCT
dpc-571	245	5	10	10	NUM
dpc-571	245	6	.	.	PUNCT
dpc-571	246	1	hussussian	hussussian	PROPN
dpc-571	246	2	cj	cj	PROPN
dpc-571	246	3	,	,	PUNCT
dpc-571	246	4	struewing	struewing	NOUN
dpc-571	246	5	jp	jp	PROPN
dpc-571	246	6	,	,	PUNCT
dpc-571	246	7	goldstein	goldstein	PROPN
dpc-571	246	8	am	am	PROPN
dpc-571	246	9	,	,	PUNCT
dpc-571	247	1	et	et	PROPN
dpc-571	247	2	 	 	SPACE
dpc-571	247	3	al	al	PROPN
dpc-571	247	4	.	.	PROPN
dpc-571	247	5	germline	germline	PROPN
dpc-571	247	6	p16	p16	NOUN
dpc-571	247	7	mutations	mutation	NOUN
dpc-571	247	8	in	in	ADP
dpc-571	247	9	familial	familial	ADJ
dpc-571	247	10	melanoma	melanoma	NOUN
dpc-571	247	11	.	.	PUNCT
dpc-571	248	1	nat	nat	PROPN
dpc-571	248	2	genet	genet	PROPN
dpc-571	248	3	.	.	PUNCT
dpc-571	249	1	1994;8(1):15	1994;8(1):15	NUM
dpc-571	249	2	-	-	SYM
dpc-571	249	3	21	21	NUM
dpc-571	249	4	.	.	PUNCT
dpc-571	250	1	11	11	NUM
dpc-571	250	2	.	.	PUNCT
dpc-571	251	1	kamb	kamb	PROPN
dpc-571	251	2	a	a	DET
dpc-571	251	3	,	,	PUNCT
dpc-571	251	4	shattuck	shattuck	NOUN
dpc-571	251	5	-	-	PUNCT
dpc-571	251	6	eidens	eiden	NOUN
dpc-571	251	7	d	d	NOUN
dpc-571	251	8	,	,	PUNCT
dpc-571	251	9	eeles	eele	VERB
dpc-571	251	10	r	r	NOUN
dpc-571	251	11	,	,	PUNCT
dpc-571	251	12	et	et	NOUN
dpc-571	251	13	 	 	SPACE
dpc-571	251	14	al	al	PROPN
dpc-571	251	15	.	.	PUNCT
dpc-571	252	1	analysis	analysis	NOUN
dpc-571	252	2	of	of	ADP
dpc-571	252	3	the	the	DET
dpc-571	252	4	p16	p16	NOUN
dpc-571	252	5	gene	gene	NOUN
dpc-571	252	6	(	(	PUNCT
dpc-571	252	7	cdkn2	cdkn2	NOUN
dpc-571	252	8	)	)	PUNCT
dpc-571	252	9	as	as	ADP
dpc-571	252	10	a	a	DET
dpc-571	252	11	candidate	candidate	NOUN
dpc-571	252	12	for	for	ADP
dpc-571	252	13	the	the	DET
dpc-571	252	14	chromosome	chromosome	NOUN
dpc-571	252	15	9p	9p	NUM
dpc-571	252	16	melanoma	melanoma	NOUN
dpc-571	252	17	susceptibility	susceptibility	NOUN
dpc-571	252	18	locus	locus	NOUN
dpc-571	252	19	.	.	PUNCT
dpc-571	253	1	nat	nat	PROPN
dpc-571	253	2	genet	genet	PROPN
dpc-571	253	3	.	.	PUNCT
dpc-571	254	1	1994;8(1):23	1994;8(1):23	NUM
dpc-571	254	2	-	-	SYM
dpc-571	254	3	26	26	NUM
dpc-571	254	4	.	.	PUNCT
dpc-571	255	1	12	12	NUM
dpc-571	255	2	.	.	PUNCT
dpc-571	256	1	goldstein	goldstein	PROPN
dpc-571	256	2	am	am	PROPN
dpc-571	256	3	,	,	PUNCT
dpc-571	256	4	chan	chan	PROPN
dpc-571	256	5	m	m	PROPN
dpc-571	256	6	,	,	PUNCT
dpc-571	256	7	harland	harland	PROPN
dpc-571	256	8	m	m	PROPN
dpc-571	256	9	,	,	PUNCT
dpc-571	256	10	et	et	PROPN
dpc-571	256	11	 	 	SPACE
dpc-571	256	12	al	al	PROPN
dpc-571	256	13	.	.	PROPN
dpc-571	256	14	high	high	ADJ
dpc-571	256	15	-	-	PUNCT
dpc-571	256	16	risk	risk	NOUN
dpc-571	256	17	melanoma	melanoma	NOUN
dpc-571	256	18	susceptibility	susceptibility	NOUN
dpc-571	256	19	genes	gene	NOUN
dpc-571	256	20	and	and	CCONJ
dpc-571	256	21	pancreatic	pancreatic	ADJ
dpc-571	256	22	cancer	cancer	NOUN
dpc-571	256	23	,	,	PUNCT
dpc-571	256	24	neural	neural	ADJ
dpc-571	256	25	system	system	NOUN
dpc-571	256	26	tumors	tumor	NOUN
dpc-571	256	27	,	,	PUNCT
dpc-571	256	28	and	and	CCONJ
dpc-571	256	29	uveal	uveal	ADJ
dpc-571	256	30	melanoma	melanoma	NOUN
dpc-571	256	31	across	across	ADP
dpc-571	256	32	genomel	genomel	NOUN
dpc-571	256	33	.	.	PUNCT
dpc-571	257	1	cancer	cancer	NOUN
dpc-571	257	2	res	re	NOUN
dpc-571	257	3	.	.	PUNCT
dpc-571	258	1	2006;66(20):9818	2006;66(20):9818	NUM
dpc-571	258	2	-	-	SYM
dpc-571	258	3	9828	9828	NUM
dpc-571	258	4	.	.	PUNCT
dpc-571	259	1	13	13	NUM
dpc-571	259	2	.	.	X
dpc-571	260	1	goldstein	goldstein	PROPN
dpc-571	260	2	a	a	PROPN
dpc-571	260	3	,	,	PUNCT
dpc-571	260	4	chan	chan	PROPN
dpc-571	260	5	m	m	PROPN
dpc-571	260	6	,	,	PUNCT
dpc-571	260	7	harland	harland	PROPN
dpc-571	260	8	m	m	PROPN
dpc-571	260	9	,	,	PUNCT
dpc-571	260	10	et	et	PROPN
dpc-571	260	11	 	 	SPACE
dpc-571	260	12	al	al	PROPN
dpc-571	260	13	.	.	PROPN
dpc-571	260	14	features	feature	NOUN
dpc-571	260	15	associated	associate	VERB
dpc-571	260	16	with	with	ADP
dpc-571	260	17	germline	germline	NOUN
dpc-571	260	18	cdkn2a	cdkn2a	PROPN
dpc-571	260	19	mutations	mutation	NOUN
dpc-571	260	20	:	:	PUNCT
dpc-571	260	21	a	a	DET
dpc-571	260	22	genomel	genomel	NOUN
dpc-571	260	23	study	study	NOUN
dpc-571	260	24	of	of	ADP
dpc-571	260	25	melanoma	melanoma	NOUN
dpc-571	260	26	-	-	PUNCT
dpc-571	260	27	prone	prone	ADJ
dpc-571	260	28	families	family	NOUN
dpc-571	260	29	from	from	ADP
dpc-571	260	30	three	three	NUM
dpc-571	260	31	continents	continent	NOUN
dpc-571	260	32	.	.	PUNCT
dpc-571	261	1	j	j	PROPN
dpc-571	261	2	med	med	PROPN
dpc-571	261	3	genet	genet	NOUN
dpc-571	261	4	.	.	PUNCT
dpc-571	262	1	2007;44(2):99	2007;44(2):99	NUM
dpc-571	262	2	-	-	SYM
dpc-571	262	3	106	106	NUM
dpc-571	262	4	.	.	PUNCT
dpc-571	263	1	14	14	NUM
dpc-571	263	2	.	.	PUNCT
dpc-571	264	1	bahuau	bahuau	PROPN
dpc-571	264	2	m	m	PROPN
dpc-571	264	3	,	,	PUNCT
dpc-571	264	4	vidaud	vidaud	VERB
dpc-571	264	5	d	d	PROPN
dpc-571	264	6	,	,	PUNCT
dpc-571	264	7	jenkins	jenkins	PROPN
dpc-571	264	8	rb	rb	PROPN
dpc-571	264	9	,	,	PUNCT
dpc-571	264	10	et	et	NOUN
dpc-571	264	11	 	 	SPACE
dpc-571	264	12	al	al	PROPN
dpc-571	264	13	.	.	PROPN
dpc-571	264	14	germ	germ	NOUN
dpc-571	264	15	-	-	PUNCT
dpc-571	264	16	line	line	NOUN
dpc-571	264	17	deletion	deletion	NOUN
dpc-571	264	18	involving	involve	VERB
dpc-571	264	19	the	the	DET
dpc-571	264	20	ink4	ink4	PROPN
dpc-571	264	21	locus	locus	NOUN
dpc-571	264	22	in	in	ADP
dpc-571	264	23	familial	familial	ADJ
dpc-571	264	24	proneness	proneness	NOUN
dpc-571	264	25	to	to	ADP
dpc-571	264	26	melanoma	melanoma	NOUN
dpc-571	264	27	and	and	CCONJ
dpc-571	264	28	nervous	nervous	ADJ
dpc-571	264	29	system	system	NOUN
dpc-571	264	30	tumors	tumor	NOUN
dpc-571	264	31	.	.	PUNCT
dpc-571	265	1	cancer	cancer	NOUN
dpc-571	265	2	res	re	NOUN
dpc-571	265	3	.	.	PUNCT
dpc-571	266	1	1998;58(11):2298	1998;58(11):2298	NUM
dpc-571	266	2	-	-	SYM
dpc-571	266	3	2303	2303	NUM
dpc-571	266	4	.	.	PUNCT
dpc-571	267	1	16	16	NUM
dpc-571	267	2	review	review	NOUN
dpc-571	267	3	|	|	ADV
dpc-571	267	4	dermatol	dermatol	ADJ
dpc-571	267	5	pract	pract	NOUN
dpc-571	267	6	concept	concept	NOUN
dpc-571	267	7	2019;9(1):3	2019;9(1):3	PROPN
dpc-571	267	8	52	52	NUM
dpc-571	267	9	.	.	PUNCT
dpc-571	268	1	carbone	carbone	PROPN
dpc-571	268	2	m	m	PROPN
dpc-571	268	3	,	,	PUNCT
dpc-571	268	4	yang	yang	PROPN
dpc-571	268	5	h	h	PROPN
dpc-571	268	6	,	,	PUNCT
dpc-571	268	7	pass	pass	VERB
dpc-571	268	8	hi	hi	INTJ
dpc-571	268	9	,	,	PUNCT
dpc-571	268	10	et	et	PROPN
dpc-571	268	11	 	 	SPACE
dpc-571	268	12	al	al	PROPN
dpc-571	268	13	.	.	PROPN
dpc-571	268	14	bap1	bap1	PROPN
dpc-571	268	15	and	and	CCONJ
dpc-571	268	16	cancer	cancer	NOUN
dpc-571	268	17	.	.	PUNCT
dpc-571	269	1	nat	nat	PROPN
dpc-571	269	2	rev	rev	PROPN
dpc-571	269	3	cancer	cancer	NOUN
dpc-571	269	4	.	.	PUNCT
dpc-571	270	1	2013;13(3):153	2013;13(3):153	NUM
dpc-571	270	2	-	-	SYM
dpc-571	270	3	159	159	NUM
dpc-571	270	4	.	.	PUNCT
dpc-571	271	1	53	53	NUM
dpc-571	271	2	.	.	PUNCT
dpc-571	272	1	battaglia	battaglia	PROPN
dpc-571	272	2	a.	a.	PROPN
dpc-571	272	3	the	the	DET
dpc-571	272	4	importance	importance	NOUN
dpc-571	272	5	of	of	ADP
dpc-571	272	6	multidisciplinary	multidisciplinary	ADJ
dpc-571	272	7	approach	approach	NOUN
dpc-571	272	8	in	in	ADP
dpc-571	272	9	early	early	ADJ
dpc-571	272	10	detection	detection	NOUN
dpc-571	272	11	of	of	ADP
dpc-571	272	12	bap1	bap1	PROPN
dpc-571	272	13	tumor	tumor	PROPN
dpc-571	272	14	predisposition	predisposition	NOUN
dpc-571	272	15	syndrome	syndrome	NOUN
dpc-571	272	16	:	:	PUNCT
dpc-571	272	17	clinical	clinical	ADJ
dpc-571	272	18	management	management	NOUN
dpc-571	272	19	and	and	CCONJ
dpc-571	272	20	risk	risk	NOUN
dpc-571	272	21	assessment	assessment	NOUN
dpc-571	272	22	.	.	PUNCT
dpc-571	273	1	clin	clin	PROPN
dpc-571	273	2	med	med	PROPN
dpc-571	273	3	insights	insight	NOUN
dpc-571	273	4	oncol	oncol	ADJ
dpc-571	273	5	.	.	PUNCT
dpc-571	274	1	2014;8:37	2014;8:37	NUM
dpc-571	274	2	-	-	SYM
dpc-571	274	3	47	47	NUM
dpc-571	274	4	.	.	PUNCT
dpc-571	275	1	54	54	NUM
dpc-571	275	2	.	.	NUM
dpc-571	275	3	aoude	aoude	PROPN
dpc-571	275	4	lg	lg	PROPN
dpc-571	275	5	,	,	PUNCT
dpc-571	275	6	pritchard	pritchard	PROPN
dpc-571	275	7	al	al	PROPN
dpc-571	275	8	,	,	PUNCT
dpc-571	275	9	robles	robles	PROPN
dpc-571	275	10	-	-	PUNCT
dpc-571	275	11	espinoza	espinoza	PROPN
dpc-571	275	12	cd	cd	PROPN
dpc-571	275	13	,	,	PUNCT
dpc-571	276	1	et	et	PROPN
dpc-571	276	2	 	 	SPACE
dpc-571	276	3	al	al	PROPN
dpc-571	276	4	.	.	PUNCT
dpc-571	276	5	nonsense	nonsense	NOUN
dpc-571	276	6	mutations	mutation	NOUN
dpc-571	276	7	in	in	ADP
dpc-571	276	8	the	the	DET
dpc-571	276	9	shelterin	shelterin	NOUN
dpc-571	276	10	complex	complex	ADJ
dpc-571	276	11	genes	gene	NOUN
dpc-571	276	12	acd	acd	NOUN
dpc-571	276	13	and	and	CCONJ
dpc-571	276	14	terf2ip	terf2ip	NOUN
dpc-571	276	15	in	in	ADP
dpc-571	276	16	familial	familial	ADJ
dpc-571	276	17	melanoma	melanoma	NOUN
dpc-571	276	18	.	.	PUNCT
dpc-571	277	1	j	j	PROPN
dpc-571	277	2	natl	natl	PROPN
dpc-571	277	3	cancer	cancer	PROPN
dpc-571	277	4	inst	inst	PROPN
dpc-571	277	5	.	.	PROPN
dpc-571	277	6	2014;107(2	2014;107(2	NOUN
dpc-571	277	7	)	)	PUNCT
dpc-571	277	8	.	.	PUNCT
dpc-571	278	1	55	55	NUM
dpc-571	278	2	.	.	PUNCT
dpc-571	279	1	gerstenblith	gerstenblith	PROPN
dpc-571	279	2	mr	mr	PROPN
dpc-571	279	3	,	,	PUNCT
dpc-571	279	4	goldstein	goldstein	PROPN
dpc-571	279	5	am	am	PROPN
dpc-571	279	6	,	,	PUNCT
dpc-571	279	7	fargnoli	fargnoli	PROPN
dpc-571	279	8	mc	mc	PROPN
dpc-571	279	9	,	,	PUNCT
dpc-571	279	10	peris	peris	PROPN
dpc-571	279	11	k	k	PROPN
dpc-571	279	12	,	,	PUNCT
dpc-571	279	13	landi	landi	PROPN
dpc-571	279	14	mt	mt	PROPN
dpc-571	279	15	.	.	PROPN
dpc-571	279	16	comprehensive	comprehensive	ADJ
dpc-571	279	17	evaluation	evaluation	NOUN
dpc-571	279	18	of	of	ADP
dpc-571	279	19	allele	allele	NOUN
dpc-571	279	20	frequency	frequency	NOUN
dpc-571	279	21	differences	difference	NOUN
dpc-571	279	22	of	of	ADP
dpc-571	279	23	mc1r	mc1r	NOUN
dpc-571	279	24	variants	variant	NOUN
dpc-571	279	25	across	across	ADP
dpc-571	279	26	populations	population	NOUN
dpc-571	279	27	.	.	PUNCT
dpc-571	280	1	hum	hum	PROPN
dpc-571	280	2	mutat	mutat	PROPN
dpc-571	280	3	.	.	PUNCT
dpc-571	281	1	2007;28(5):495505	2007;28(5):495505	NUM
dpc-571	281	2	.	.	PUNCT
dpc-571	282	1	56	56	NUM
dpc-571	282	2	.	.	PUNCT
dpc-571	282	3	kanetsky	kanetsky	PROPN
dpc-571	282	4	pa	pa	PROPN
dpc-571	282	5	,	,	PUNCT
dpc-571	282	6	rebbeck	rebbeck	PROPN
dpc-571	282	7	tr	tr	VERB
dpc-571	282	8	,	,	PUNCT
dpc-571	282	9	hummer	hummer	PROPN
dpc-571	282	10	aj	aj	PROPN
dpc-571	282	11	,	,	PUNCT
dpc-571	282	12	et	et	PROPN
dpc-571	282	13	 	 	SPACE
dpc-571	282	14	al	al	PROPN
dpc-571	282	15	.	.	PUNCT
dpc-571	283	1	population	population	NOUN
dpc-571	283	2	-	-	PUNCT
dpc-571	283	3	based	base	VERB
dpc-571	283	4	study	study	NOUN
dpc-571	283	5	of	of	ADP
dpc-571	283	6	natural	natural	ADJ
dpc-571	283	7	variation	variation	NOUN
dpc-571	283	8	in	in	ADP
dpc-571	283	9	the	the	DET
dpc-571	283	10	melanocortin-1	melanocortin-1	NUM
dpc-571	283	11	receptor	receptor	NOUN
dpc-571	283	12	gene	gene	NOUN
dpc-571	283	13	and	and	CCONJ
dpc-571	283	14	melanoma	melanoma	NOUN
dpc-571	283	15	.	.	PUNCT
dpc-571	284	1	cancer	cancer	NOUN
dpc-571	284	2	res	re	NOUN
dpc-571	284	3	.	.	PUNCT
dpc-571	285	1	2006;66(18):9330	2006;66(18):9330	NUM
dpc-571	285	2	-	-	SYM
dpc-571	285	3	9337	9337	NUM
dpc-571	285	4	.	.	PUNCT
dpc-571	286	1	57	57	NUM
dpc-571	286	2	.	.	PUNCT
dpc-571	287	1	beaumont	beaumont	PROPN
dpc-571	287	2	ka	ka	PROPN
dpc-571	287	3	,	,	PUNCT
dpc-571	287	4	shekar	shekar	PROPN
dpc-571	287	5	sn	sn	PROPN
dpc-571	287	6	,	,	PUNCT
dpc-571	287	7	newton	newton	PROPN
dpc-571	287	8	ra	ra	PROPN
dpc-571	287	9	,	,	PUNCT
dpc-571	287	10	et	et	PROPN
dpc-571	287	11	 	 	SPACE
dpc-571	287	12	al	al	PROPN
dpc-571	287	13	.	.	PUNCT
dpc-571	287	14	receptor	receptor	NOUN
dpc-571	287	15	function	function	NOUN
dpc-571	287	16	,	,	PUNCT
dpc-571	287	17	dominant	dominant	ADJ
dpc-571	287	18	negative	negative	ADJ
dpc-571	287	19	activity	activity	NOUN
dpc-571	287	20	and	and	CCONJ
dpc-571	287	21	phenotype	phenotype	NOUN
dpc-571	287	22	correlations	correlation	NOUN
dpc-571	287	23	for	for	ADP
dpc-571	287	24	mc1r	mc1r	PROPN
dpc-571	287	25	variant	variant	ADJ
dpc-571	287	26	alleles	allele	NOUN
dpc-571	287	27	.	.	PUNCT
dpc-571	288	1	hum	hum	PROPN
dpc-571	288	2	mol	mol	ADP
dpc-571	288	3	genet	genet	NOUN
dpc-571	288	4	.	.	PUNCT
dpc-571	289	1	2007;16(18):2249	2007;16(18):2249	X
dpc-571	289	2	-	-	SYM
dpc-571	289	3	2260	2260	NUM
dpc-571	289	4	.	.	PUNCT
dpc-571	290	1	58	58	NUM
dpc-571	290	2	.	.	PUNCT
dpc-571	291	1	newton	newton	PROPN
dpc-571	291	2	ra	ra	PROPN
dpc-571	291	3	,	,	PUNCT
dpc-571	291	4	roberts	roberts	PROPN
dpc-571	291	5	dw	dw	PROPN
dpc-571	291	6	,	,	PUNCT
dpc-571	291	7	leonard	leonard	PROPN
dpc-571	291	8	jh	jh	PROPN
dpc-571	291	9	,	,	PUNCT
dpc-571	291	10	sturm	sturm	PROPN
dpc-571	291	11	ra	ra	PROPN
dpc-571	291	12	.	.	PUNCT
dpc-571	292	1	human	human	ADJ
dpc-571	292	2	melanocytes	melanocyte	NOUN
dpc-571	292	3	expressing	express	VERB
dpc-571	292	4	mc1r	mc1r	PROPN
dpc-571	292	5	variant	variant	ADJ
dpc-571	292	6	alleles	allele	NOUN
dpc-571	292	7	show	show	VERB
dpc-571	292	8	impaired	impaired	ADJ
dpc-571	292	9	activation	activation	NOUN
dpc-571	292	10	of	of	ADP
dpc-571	292	11	multiple	multiple	ADJ
dpc-571	292	12	signaling	signal	VERB
dpc-571	292	13	pathways	pathway	NOUN
dpc-571	292	14	.	.	PUNCT
dpc-571	293	1	peptides	peptide	NOUN
dpc-571	293	2	.	.	PUNCT
dpc-571	294	1	2007;28(12):23872396	2007;28(12):23872396	NUM
dpc-571	294	2	.	.	X
dpc-571	295	1	59	59	NUM
dpc-571	295	2	.	.	PUNCT
dpc-571	296	1	cuéllar	cuéllar	PROPN
dpc-571	296	2	f	f	PROPN
dpc-571	296	3	,	,	PUNCT
dpc-571	296	4	puig	puig	PROPN
dpc-571	296	5	s	s	PROPN
dpc-571	296	6	,	,	PUNCT
dpc-571	296	7	kolm	kolm	NOUN
dpc-571	296	8	i	i	PRON
dpc-571	296	9	,	,	PUNCT
dpc-571	296	10	et	et	PROPN
dpc-571	296	11	 	 	SPACE
dpc-571	296	12	al	al	PROPN
dpc-571	296	13	.	.	PROPN
dpc-571	296	14	dermoscopic	dermoscopic	PROPN
dpc-571	296	15	features	feature	NOUN
dpc-571	296	16	of	of	ADP
dpc-571	296	17	melanomas	melanoma	NOUN
dpc-571	296	18	associated	associate	VERB
dpc-571	296	19	with	with	ADP
dpc-571	296	20	mc1r	mc1r	PROPN
dpc-571	296	21	variants	variant	NOUN
dpc-571	296	22	in	in	ADP
dpc-571	296	23	spanish	spanish	ADJ
dpc-571	296	24	cdkn2a	cdkn2a	PROPN
dpc-571	296	25	mutation	mutation	NOUN
dpc-571	296	26	carriers	carrier	NOUN
dpc-571	296	27	.	.	PUNCT
dpc-571	297	1	br	br	PROPN
dpc-571	297	2	j	j	PROPN
dpc-571	297	3	dermatol	dermatol	NOUN
dpc-571	297	4	.	.	PUNCT
dpc-571	298	1	2009;160(1):48	2009;160(1):48	X
dpc-571	298	2	-	-	PUNCT
dpc-571	298	3	53	53	NUM
dpc-571	298	4	.	.	PUNCT
dpc-571	298	5	60	60	NUM
dpc-571	298	6	.	.	PUNCT
dpc-571	299	1	fargnoli	fargnoli	PROPN
dpc-571	299	2	mc	mc	PROPN
dpc-571	299	3	,	,	PUNCT
dpc-571	299	4	sera	sera	PROPN
dpc-571	299	5	f	f	PROPN
dpc-571	299	6	,	,	PUNCT
dpc-571	299	7	suppa	suppa	PROPN
dpc-571	299	8	m	m	PROPN
dpc-571	299	9	,	,	PUNCT
dpc-571	299	10	et	et	PROPN
dpc-571	299	11	 	 	SPACE
dpc-571	299	12	al	al	PROPN
dpc-571	299	13	.	.	PROPN
dpc-571	299	14	dermoscopic	dermoscopic	PROPN
dpc-571	299	15	features	feature	NOUN
dpc-571	299	16	of	of	ADP
dpc-571	299	17	cutaneous	cutaneous	ADJ
dpc-571	299	18	melanoma	melanoma	NOUN
dpc-571	299	19	are	be	AUX
dpc-571	299	20	associated	associate	VERB
dpc-571	299	21	with	with	ADP
dpc-571	299	22	clinical	clinical	ADJ
dpc-571	299	23	characteristics	characteristic	NOUN
dpc-571	299	24	of	of	ADP
dpc-571	299	25	patients	patient	NOUN
dpc-571	299	26	and	and	CCONJ
dpc-571	299	27	tumours	tumour	NOUN
dpc-571	299	28	and	and	CCONJ
dpc-571	299	29	with	with	ADP
dpc-571	299	30	mc1r	mc1r	PROPN
dpc-571	299	31	genotype	genotype	NOUN
dpc-571	299	32	.	.	PUNCT
dpc-571	300	1	j	j	PROPN
dpc-571	300	2	eur	eur	PROPN
dpc-571	300	3	acad	acad	PROPN
dpc-571	300	4	dermatol	dermatol	NOUN
dpc-571	300	5	venereol	venereol	NOUN
dpc-571	300	6	.	.	PUNCT
dpc-571	301	1	2014;28(12):1768	2014;28(12):1768	NOUN
dpc-571	301	2	-	-	SYM
dpc-571	301	3	1775	1775	NUM
dpc-571	301	4	.	.	PUNCT
dpc-571	302	1	61	61	NUM
dpc-571	302	2	.	.	PUNCT
dpc-571	302	3	quint	quint	PROPN
dpc-571	302	4	kd	kd	PROPN
dpc-571	302	5	,	,	PUNCT
dpc-571	302	6	van	van	PROPN
dpc-571	302	7	der	der	PROPN
dpc-571	302	8	rhee	rhee	PROPN
dpc-571	302	9	ji	ji	PROPN
dpc-571	302	10	,	,	PUNCT
dpc-571	302	11	gruis	gruis	ADJ
dpc-571	302	12	na	na	NOUN
dpc-571	302	13	,	,	PUNCT
dpc-571	302	14	et	et	PROPN
dpc-571	302	15	 	 	SPACE
dpc-571	302	16	al	al	PROPN
dpc-571	302	17	.	.	PROPN
dpc-571	302	18	melanocortin	melanocortin	PROPN
dpc-571	302	19	1	1	NUM
dpc-571	302	20	receptor	receptor	NOUN
dpc-571	302	21	(	(	PUNCT
dpc-571	302	22	mc1r	mc1r	PROPN
dpc-571	302	23	)	)	PUNCT
dpc-571	302	24	variants	variant	NOUN
dpc-571	302	25	in	in	ADP
dpc-571	302	26	high	high	ADJ
dpc-571	302	27	melanoma	melanoma	NOUN
dpc-571	302	28	risk	risk	NOUN
dpc-571	302	29	patients	patient	NOUN
dpc-571	302	30	are	be	AUX
dpc-571	302	31	associated	associate	VERB
dpc-571	302	32	with	with	ADP
dpc-571	302	33	specific	specific	ADJ
dpc-571	302	34	dermoscopic	dermoscopic	ADJ
dpc-571	302	35	abcd	abcd	NOUN
dpc-571	302	36	features	feature	NOUN
dpc-571	302	37	.	.	PUNCT
dpc-571	303	1	acta	acta	PROPN
dpc-571	303	2	derm	derm	PROPN
dpc-571	303	3	venereol	venereol	NOUN
dpc-571	303	4	.	.	PUNCT
dpc-571	304	1	2012;92(6):587	2012;92(6):587	NUM
dpc-571	304	2	-	-	SYM
dpc-571	304	3	592	592	NUM
dpc-571	304	4	.	.	PUNCT
dpc-571	305	1	62	62	NUM
dpc-571	305	2	.	.	PUNCT
dpc-571	306	1	koludrovic	koludrovic	PROPN
dpc-571	306	2	d	d	PROPN
dpc-571	306	3	,	,	PUNCT
dpc-571	306	4	davidson	davidson	PROPN
dpc-571	306	5	i.	i.	PROPN
dpc-571	306	6	mitf	mitf	PROPN
dpc-571	306	7	,	,	PUNCT
dpc-571	306	8	the	the	DET
dpc-571	306	9	janus	janus	PROPN
dpc-571	306	10	transcription	transcription	NOUN
dpc-571	306	11	factor	factor	NOUN
dpc-571	306	12	of	of	ADP
dpc-571	306	13	melanoma	melanoma	NOUN
dpc-571	306	14	.	.	PUNCT
dpc-571	307	1	future	future	ADJ
dpc-571	307	2	oncol	oncol	ADJ
dpc-571	307	3	.	.	PUNCT
dpc-571	308	1	2013;9(2):235	2013;9(2):235	X
dpc-571	308	2	-	-	PUNCT
dpc-571	308	3	244	244	NUM
dpc-571	308	4	.	.	PUNCT
dpc-571	309	1	63	63	NUM
dpc-571	309	2	.	.	PUNCT
dpc-571	310	1	potrony	potrony	PROPN
dpc-571	310	2	m	m	PROPN
dpc-571	310	3	,	,	PUNCT
dpc-571	310	4	puig	puig	PROPN
dpc-571	310	5	-	-	PUNCT
dpc-571	310	6	butille	butille	PROPN
dpc-571	310	7	ja	ja	PROPN
dpc-571	310	8	,	,	PUNCT
dpc-571	310	9	aguilera	aguilera	PROPN
dpc-571	310	10	p	p	X
dpc-571	310	11	,	,	PUNCT
dpc-571	310	12	et	et	PROPN
dpc-571	310	13	 	 	SPACE
dpc-571	310	14	al	al	PROPN
dpc-571	310	15	.	.	PUNCT
dpc-571	310	16	prevalence	prevalence	NOUN
dpc-571	310	17	of	of	ADP
dpc-571	310	18	mitf	mitf	PROPN
dpc-571	310	19	p.e318k	p.e318k	PROPN
dpc-571	310	20	in	in	ADP
dpc-571	310	21	patients	patient	NOUN
dpc-571	310	22	with	with	ADP
dpc-571	310	23	melanoma	melanoma	PROPN
dpc-571	310	24	independent	independent	ADJ
dpc-571	310	25	of	of	ADP
dpc-571	310	26	the	the	DET
dpc-571	310	27	presence	presence	NOUN
dpc-571	310	28	of	of	ADP
dpc-571	310	29	cdkn2a	cdkn2a	PROPN
dpc-571	310	30	causative	causative	ADJ
dpc-571	310	31	mutations	mutation	NOUN
dpc-571	310	32	.	.	PUNCT
dpc-571	311	1	jama	jama	PROPN
dpc-571	311	2	dermatol	dermatol	NOUN
dpc-571	311	3	.	.	PUNCT
dpc-571	312	1	2016;152(4):405	2016;152(4):405	NUM
dpc-571	312	2	-	-	SYM
dpc-571	312	3	412	412	NUM
dpc-571	312	4	.	.	NOUN
dpc-571	313	1	64	64	NUM
dpc-571	313	2	.	.	PUNCT
dpc-571	314	1	bassoli	bassoli	PROPN
dpc-571	314	2	s	s	PROPN
dpc-571	314	3	,	,	PUNCT
dpc-571	314	4	pellegrini	pellegrini	PROPN
dpc-571	314	5	c	c	PROPN
dpc-571	314	6	,	,	PUNCT
dpc-571	314	7	longo	longo	PROPN
dpc-571	314	8	c	c	PROPN
dpc-571	314	9	,	,	PUNCT
dpc-571	314	10	et	et	PROPN
dpc-571	314	11	 	 	SPACE
dpc-571	314	12	al	al	PROPN
dpc-571	314	13	.	.	PROPN
dpc-571	315	1	clinical	clinical	PROPN
dpc-571	315	2	,	,	PUNCT
dpc-571	315	3	dermoscopic	dermoscopic	NOUN
dpc-571	315	4	,	,	PUNCT
dpc-571	315	5	and	and	CCONJ
dpc-571	315	6	confocal	confocal	ADJ
dpc-571	315	7	features	feature	NOUN
dpc-571	315	8	of	of	ADP
dpc-571	315	9	nevi	nevi	NOUN
dpc-571	315	10	and	and	CCONJ
dpc-571	315	11	melanomas	melanoma	NOUN
dpc-571	315	12	in	in	ADP
dpc-571	315	13	a	a	DET
dpc-571	315	14	multiple	multiple	ADJ
dpc-571	315	15	primary	primary	ADJ
dpc-571	315	16	melanoma	melanoma	NOUN
dpc-571	315	17	patient	patient	ADJ
dpc-571	315	18	with	with	ADP
dpc-571	315	19	the	the	DET
dpc-571	315	20	mitf	mitf	ADJ
dpc-571	315	21	p.e318k	p.e318k	PROPN
dpc-571	315	22	homozygous	homozygous	ADJ
dpc-571	315	23	mutation	mutation	NOUN
dpc-571	315	24	.	.	PUNCT
dpc-571	316	1	melanoma	melanoma	NOUN
dpc-571	316	2	res	re	NOUN
dpc-571	316	3	.	.	PUNCT
dpc-571	317	1	2018;28(2):166	2018;28(2):166	NUM
dpc-571	317	2	-	-	SYM
dpc-571	317	3	169	169	NUM
dpc-571	317	4	.	.	PUNCT
dpc-571	318	1	65	65	NUM
dpc-571	318	2	.	.	PUNCT
dpc-571	319	1	badenas	badena	VERB
dpc-571	320	1	c	c	X
dpc-571	320	2	,	,	PUNCT
dpc-571	320	3	aguilera	aguilera	PROPN
dpc-571	320	4	p	p	X
dpc-571	320	5	,	,	PUNCT
dpc-571	320	6	puig	puig	NOUN
dpc-571	320	7	-	-	PUNCT
dpc-571	320	8	butillé	butillé	PROPN
dpc-571	320	9	ja	ja	PROPN
dpc-571	320	10	,	,	PUNCT
dpc-571	320	11	et	et	PROPN
dpc-571	320	12	 	 	SPACE
dpc-571	320	13	al	al	PROPN
dpc-571	320	14	.	.	PUNCT
dpc-571	320	15	genetic	genetic	ADJ
dpc-571	320	16	counseling	counseling	NOUN
dpc-571	320	17	in	in	ADP
dpc-571	320	18	melanoma	melanoma	NOUN
dpc-571	320	19	.	.	PUNCT
dpc-571	321	1	dermatol	dermatol	NOUN
dpc-571	321	2	ther	ther	ADV
dpc-571	321	3	.	.	PUNCT
dpc-571	322	1	2012;25(5):397	2012;25(5):397	NUM
dpc-571	322	2	-	-	SYM
dpc-571	322	3	402	402	NUM
dpc-571	322	4	.	.	PUNCT
dpc-571	323	1	66	66	NUM
dpc-571	323	2	.	.	PUNCT
dpc-571	323	3	canto	canto	PROPN
dpc-571	323	4	mi	mi	PROPN
dpc-571	323	5	,	,	PUNCT
dpc-571	323	6	harinck	harinck	ADJ
dpc-571	323	7	f	f	X
dpc-571	323	8	,	,	PUNCT
dpc-571	323	9	hruban	hruban	PROPN
dpc-571	323	10	rh	rh	PROPN
dpc-571	323	11	,	,	PUNCT
dpc-571	323	12	et	et	PROPN
dpc-571	323	13	 	 	SPACE
dpc-571	323	14	al	al	PROPN
dpc-571	323	15	;	;	PUNCT
dpc-571	324	1	international	international	ADJ
dpc-571	324	2	cancer	cancer	NOUN
dpc-571	324	3	of	of	ADP
dpc-571	324	4	pancreas	pancreas	NOUN
dpc-571	324	5	screening	screen	VERB
dpc-571	324	6	(	(	PUNCT
dpc-571	324	7	caps	cap	NOUN
dpc-571	324	8	)	)	PUNCT
dpc-571	324	9	consortium	consortium	NOUN
dpc-571	324	10	.	.	PUNCT
dpc-571	325	1	international	international	ADJ
dpc-571	325	2	cancer	cancer	NOUN
dpc-571	325	3	of	of	ADP
dpc-571	325	4	the	the	DET
dpc-571	325	5	pancreas	pancreas	NOUN
dpc-571	325	6	screening	screen	VERB
dpc-571	325	7	(	(	PUNCT
dpc-571	325	8	caps	cap	NOUN
dpc-571	325	9	)	)	PUNCT
dpc-571	325	10	consortium	consortium	NOUN
dpc-571	325	11	summit	summit	NOUN
dpc-571	325	12	on	on	ADP
dpc-571	325	13	the	the	DET
dpc-571	325	14	management	management	NOUN
dpc-571	325	15	of	of	ADP
dpc-571	325	16	patients	patient	NOUN
dpc-571	325	17	with	with	ADP
dpc-571	325	18	increased	increase	VERB
dpc-571	325	19	risk	risk	NOUN
dpc-571	325	20	for	for	ADP
dpc-571	325	21	familial	familial	ADJ
dpc-571	325	22	pancreatic	pancreatic	ADJ
dpc-571	325	23	cancer	cancer	NOUN
dpc-571	325	24	.	.	PUNCT
dpc-571	326	1	gut	gut	NOUN
dpc-571	326	2	.	.	PUNCT
dpc-571	327	1	2013;62(3):339	2013;62(3):339	PROPN
dpc-571	327	2	-	-	SYM
dpc-571	327	3	347	347	NUM
dpc-571	327	4	.	.	NOUN
dpc-571	328	1	67	67	NUM
dpc-571	328	2	.	.	PUNCT
dpc-571	329	1	potrony	potrony	PROPN
dpc-571	329	2	m	m	PROPN
dpc-571	329	3	,	,	PUNCT
dpc-571	329	4	puig	puig	NOUN
dpc-571	329	5	-	-	PUNCT
dpc-571	329	6	butillé	butillé	PROPN
dpc-571	329	7	ja	ja	PROPN
dpc-571	329	8	,	,	PUNCT
dpc-571	329	9	aguilera	aguilera	PROPN
dpc-571	329	10	p	p	X
dpc-571	329	11	,	,	PUNCT
dpc-571	329	12	et	et	PROPN
dpc-571	329	13	 	 	SPACE
dpc-571	329	14	al	al	PROPN
dpc-571	329	15	.	.	PROPN
dpc-571	329	16	increased	increase	VERB
dpc-571	329	17	prevalence	prevalence	NOUN
dpc-571	329	18	of	of	ADP
dpc-571	329	19	lung	lung	NOUN
dpc-571	329	20	,	,	PUNCT
dpc-571	329	21	breast	breast	NOUN
dpc-571	329	22	,	,	PUNCT
dpc-571	329	23	and	and	CCONJ
dpc-571	329	24	pancreatic	pancreatic	ADJ
dpc-571	329	25	cancers	cancer	NOUN
dpc-571	329	26	in	in	ADP
dpc-571	329	27	addition	addition	NOUN
dpc-571	329	28	to	to	ADP
dpc-571	329	29	melanoma	melanoma	ADJ
dpc-571	329	30	risk	risk	NOUN
dpc-571	329	31	in	in	ADP
dpc-571	329	32	families	family	NOUN
dpc-571	329	33	bearing	bear	VERB
dpc-571	329	34	the	the	DET
dpc-571	329	35	cyclin	cyclin	NOUN
dpc-571	329	36	-	-	PUNCT
dpc-571	329	37	dependent	dependent	ADJ
dpc-571	329	38	kinase	kinase	NOUN
dpc-571	329	39	inhibitor	inhibitor	NOUN
dpc-571	329	40	2	2	NUM
dpc-571	329	41	°	°	PROPN
dpc-571	329	42	mutation	mutation	NOUN
dpc-571	329	43	:	:	PUNCT
dpc-571	329	44	implications	implication	NOUN
dpc-571	329	45	for	for	ADP
dpc-571	329	46	genetic	genetic	ADJ
dpc-571	329	47	counseling	counseling	NOUN
dpc-571	329	48	.	.	PUNCT
dpc-571	330	1	j	j	PROPN
dpc-571	330	2	am	be	AUX
dpc-571	330	3	acad	acad	ADJ
dpc-571	330	4	dermatol	dermatol	NOUN
dpc-571	330	5	.	.	PUNCT
dpc-571	331	1	2014;71(5):888	2014;71(5):888	NUM
dpc-571	331	2	-	-	NUM
dpc-571	331	3	895	895	NUM
dpc-571	331	4	.	.	PUNCT
dpc-571	332	1	34	34	NUM
dpc-571	332	2	.	.	PUNCT
dpc-571	333	1	gabree	gabree	PROPN
dpc-571	333	2	m	m	PROPN
dpc-571	333	3	,	,	PUNCT
dpc-571	333	4	patel	patel	PROPN
dpc-571	333	5	d	d	PROPN
dpc-571	333	6	,	,	PUNCT
dpc-571	333	7	rodgers	rodger	VERB
dpc-571	333	8	l.	l.	PROPN
dpc-571	333	9	clinical	clinical	ADJ
dpc-571	333	10	applications	application	NOUN
dpc-571	333	11	of	of	ADP
dpc-571	333	12	melanoma	melanoma	NOUN
dpc-571	333	13	genetics	genetic	NOUN
dpc-571	333	14	.	.	PUNCT
dpc-571	334	1	curr	curr	PROPN
dpc-571	334	2	treat	treat	PROPN
dpc-571	334	3	options	option	NOUN
dpc-571	334	4	oncol	oncol	ADJ
dpc-571	334	5	.	.	PUNCT
dpc-571	335	1	2014;15(2):336	2014;15(2):336	NUM
dpc-571	335	2	-	-	SYM
dpc-571	335	3	350	350	NUM
dpc-571	335	4	.	.	PUNCT
dpc-571	335	5	35	35	NUM
dpc-571	335	6	.	.	PUNCT
dpc-571	336	1	bishop	bishop	PROPN
dpc-571	336	2	dt	dt	PROPN
dpc-571	336	3	,	,	PUNCT
dpc-571	336	4	demenais	demenais	PROPN
dpc-571	336	5	f	f	PROPN
dpc-571	336	6	,	,	PUNCT
dpc-571	336	7	goldstein	goldstein	PROPN
dpc-571	336	8	am	am	PROPN
dpc-571	336	9	,	,	PUNCT
dpc-571	336	10	et	et	PROPN
dpc-571	336	11	 	 	SPACE
dpc-571	336	12	al	al	PROPN
dpc-571	336	13	.	.	PUNCT
dpc-571	336	14	geographical	geographical	ADJ
dpc-571	336	15	variation	variation	NOUN
dpc-571	336	16	in	in	ADP
dpc-571	336	17	the	the	DET
dpc-571	336	18	penetrance	penetrance	NOUN
dpc-571	336	19	of	of	ADP
dpc-571	336	20	cdkn2a	cdkn2a	ADJ
dpc-571	336	21	mutations	mutation	NOUN
dpc-571	336	22	for	for	ADP
dpc-571	336	23	melanoma	melanoma	NOUN
dpc-571	336	24	.	.	PUNCT
dpc-571	337	1	j	j	PROPN
dpc-571	337	2	natl	natl	PROPN
dpc-571	337	3	cancer	cancer	PROPN
dpc-571	337	4	inst	inst	PROPN
dpc-571	337	5	.	.	PUNCT
dpc-571	338	1	2002;94(12):894	2002;94(12):894	NUM
dpc-571	338	2	-	-	PUNCT
dpc-571	338	3	903	903	NUM
dpc-571	338	4	.	.	PUNCT
dpc-571	339	1	36	36	NUM
dpc-571	339	2	.	.	PUNCT
dpc-571	340	1	kefford	kefford	PROPN
dpc-571	340	2	rf	rf	PROPN
dpc-571	340	3	,	,	PUNCT
dpc-571	340	4	newton	newton	PROPN
dpc-571	340	5	-	-	PUNCT
dpc-571	340	6	bishop	bishop	PROPN
dpc-571	340	7	ja	ja	PROPN
dpc-571	340	8	,	,	PUNCT
dpc-571	340	9	bergman	bergman	PROPN
dpc-571	340	10	w	w	PROPN
dpc-571	340	11	,	,	PUNCT
dpc-571	340	12	ticker	ticker	PROPN
dpc-571	340	13	ma	ma	PROPN
dpc-571	340	14	.	.	PROPN
dpc-571	340	15	counseling	counseling	NOUN
dpc-571	340	16	and	and	CCONJ
dpc-571	340	17	dna	dna	NOUN
dpc-571	340	18	testing	testing	NOUN
dpc-571	340	19	for	for	ADP
dpc-571	340	20	individuals	individual	NOUN
dpc-571	340	21	perceived	perceive	VERB
dpc-571	340	22	to	to	PART
dpc-571	340	23	be	be	AUX
dpc-571	340	24	genetically	genetically	ADV
dpc-571	340	25	predisposed	predispose	VERB
dpc-571	340	26	to	to	ADP
dpc-571	340	27	melanoma	melanoma	VERB
dpc-571	340	28	:	:	PUNCT
dpc-571	340	29	a	a	DET
dpc-571	340	30	consensus	consensus	NOUN
dpc-571	340	31	statement	statement	NOUN
dpc-571	340	32	of	of	ADP
dpc-571	340	33	the	the	DET
dpc-571	340	34	melanoma	melanoma	PROPN
dpc-571	340	35	genetics	genetic	NOUN
dpc-571	340	36	consortium	consortium	NOUN
dpc-571	340	37	.	.	PUNCT
dpc-571	341	1	j	j	PROPN
dpc-571	341	2	clin	clin	PROPN
dpc-571	341	3	oncol	oncol	PROPN
dpc-571	341	4	.	.	PUNCT
dpc-571	342	1	1999;17(10):3245	1999;17(10):3245	NUM
dpc-571	342	2	-	-	SYM
dpc-571	342	3	3251	3251	NUM
dpc-571	342	4	.	.	PUNCT
dpc-571	343	1	37	37	NUM
dpc-571	343	2	.	.	PUNCT
dpc-571	344	1	blackwood	blackwood	PROPN
dpc-571	344	2	ma	ma	PROPN
dpc-571	344	3	,	,	PUNCT
dpc-571	344	4	holmes	holmes	PROPN
dpc-571	344	5	r	r	PROPN
dpc-571	344	6	,	,	PUNCT
dpc-571	344	7	synnestvedt	synnestvedt	PROPN
dpc-571	344	8	m	m	PROPN
dpc-571	344	9	,	,	PUNCT
dpc-571	344	10	et	et	PROPN
dpc-571	344	11	 	 	SPACE
dpc-571	344	12	al	al	PROPN
dpc-571	344	13	.	.	PUNCT
dpc-571	345	1	multiple	multiple	ADJ
dpc-571	345	2	primary	primary	ADJ
dpc-571	345	3	melanoma	melanoma	NOUN
dpc-571	345	4	revisited	revisit	VERB
dpc-571	345	5	.	.	PUNCT
dpc-571	346	1	cancer	cancer	NOUN
dpc-571	346	2	.	.	PUNCT
dpc-571	347	1	2002;94(8):2248	2002;94(8):2248	NUM
dpc-571	347	2	-	-	SYM
dpc-571	347	3	2255	2255	NUM
dpc-571	347	4	.	.	PUNCT
dpc-571	348	1	38	38	NUM
dpc-571	348	2	.	.	PUNCT
dpc-571	349	1	nikolaou	nikolaou	PROPN
dpc-571	349	2	v	v	PROPN
dpc-571	349	3	,	,	PUNCT
dpc-571	349	4	kang	kang	PROPN
dpc-571	349	5	x	x	PROPN
dpc-571	349	6	,	,	PUNCT
dpc-571	349	7	stratigos	stratigos	PROPN
dpc-571	349	8	a	a	PRON
dpc-571	349	9	,	,	PUNCT
dpc-571	350	1	et	et	PROPN
dpc-571	350	2	 	 	SPACE
dpc-571	350	3	al	al	PROPN
dpc-571	350	4	.	.	PROPN
dpc-571	350	5	comprehensive	comprehensive	ADJ
dpc-571	350	6	mutational	mutational	ADJ
dpc-571	350	7	analysis	analysis	NOUN
dpc-571	350	8	of	of	ADP
dpc-571	350	9	cdkn2a	cdkn2a	PROPN
dpc-571	350	10	and	and	CCONJ
dpc-571	350	11	cdk4	cdk4	NOUN
dpc-571	350	12	in	in	ADP
dpc-571	350	13	greek	greek	ADJ
dpc-571	350	14	patients	patient	NOUN
dpc-571	350	15	with	with	ADP
dpc-571	350	16	cutaneous	cutaneous	ADJ
dpc-571	350	17	melanoma	melanoma	NOUN
dpc-571	350	18	.	.	PUNCT
dpc-571	351	1	br	br	PROPN
dpc-571	351	2	j	j	PROPN
dpc-571	351	3	dermatol	dermatol	NOUN
dpc-571	351	4	.	.	PUNCT
dpc-571	352	1	2011;165(6):1219	2011;165(6):1219	NUM
dpc-571	352	2	-	-	SYM
dpc-571	352	3	1222	1222	NUM
dpc-571	352	4	.	.	PUNCT
dpc-571	353	1	39	39	NUM
dpc-571	353	2	.	.	PUNCT
dpc-571	354	1	bergman	bergman	PROPN
dpc-571	354	2	w	w	PROPN
dpc-571	354	3	,	,	PUNCT
dpc-571	354	4	gruis	gruis	ADJ
dpc-571	354	5	n.	n.	ADJ
dpc-571	354	6	familial	familial	ADJ
dpc-571	354	7	melanoma	melanoma	NOUN
dpc-571	354	8	and	and	CCONJ
dpc-571	354	9	pancreatic	pancreatic	ADJ
dpc-571	354	10	cancer	cancer	NOUN
dpc-571	354	11	.	.	PUNCT
dpc-571	355	1	n	n	PROPN
dpc-571	355	2	engl	engl	PROPN
dpc-571	355	3	j	j	PROPN
dpc-571	355	4	med	med	PROPN
dpc-571	355	5	.	.	PUNCT
dpc-571	356	1	1996;334(7):471	1996;334(7):471	NUM
dpc-571	356	2	-	-	SYM
dpc-571	356	3	472	472	NUM
dpc-571	356	4	.	.	PUNCT
dpc-571	357	1	40	40	NUM
dpc-571	357	2	.	.	X
dpc-571	358	1	goldstein	goldstein	PROPN
dpc-571	358	2	am	am	PROPN
dpc-571	358	3	,	,	PUNCT
dpc-571	358	4	fraser	fraser	PROPN
dpc-571	358	5	mc	mc	PROPN
dpc-571	358	6	,	,	PUNCT
dpc-571	358	7	struewing	struewing	NOUN
dpc-571	358	8	jp	jp	PROPN
dpc-571	358	9	,	,	PUNCT
dpc-571	358	10	et	et	PROPN
dpc-571	358	11	 	 	SPACE
dpc-571	358	12	al	al	PROPN
dpc-571	358	13	.	.	PROPN
dpc-571	358	14	increased	increase	VERB
dpc-571	358	15	risk	risk	NOUN
dpc-571	358	16	of	of	ADP
dpc-571	358	17	pancreatic	pancreatic	ADJ
dpc-571	358	18	cancer	cancer	NOUN
dpc-571	358	19	in	in	ADP
dpc-571	358	20	melanoma	melanoma	NOUN
dpc-571	358	21	-	-	PUNCT
dpc-571	358	22	prone	prone	ADJ
dpc-571	358	23	kindreds	kindred	NOUN
dpc-571	358	24	with	with	ADP
dpc-571	358	25	p16ink4a	p16ink4a	PROPN
dpc-571	358	26	mutations	mutation	NOUN
dpc-571	358	27	.	.	PUNCT
dpc-571	359	1	n	n	PROPN
dpc-571	359	2	engl	engl	PROPN
dpc-571	359	3	j	j	PROPN
dpc-571	359	4	med	med	PROPN
dpc-571	359	5	.	.	PUNCT
dpc-571	360	1	1995;333(15):970	1995;333(15):970	NUM
dpc-571	360	2	-	-	SYM
dpc-571	360	3	974	974	NUM
dpc-571	360	4	.	.	PUNCT
dpc-571	361	1	41	41	NUM
dpc-571	361	2	.	.	PUNCT
dpc-571	361	3	ghiorzo	ghiorzo	PROPN
dpc-571	361	4	p	p	NOUN
dpc-571	361	5	,	,	PUNCT
dpc-571	361	6	ciotti	ciotti	NOUN
dpc-571	361	7	p	p	X
dpc-571	361	8	,	,	PUNCT
dpc-571	361	9	mantelli	mantelli	PROPN
dpc-571	361	10	m	m	PROPN
dpc-571	361	11	,	,	PUNCT
dpc-571	361	12	et	et	PROPN
dpc-571	361	13	 	 	SPACE
dpc-571	361	14	al	al	PROPN
dpc-571	361	15	.	.	PROPN
dpc-571	361	16	characterization	characterization	NOUN
dpc-571	361	17	of	of	ADP
dpc-571	361	18	ligurian	ligurian	ADJ
dpc-571	361	19	melanoma	melanoma	NOUN
dpc-571	361	20	families	family	NOUN
dpc-571	361	21	and	and	CCONJ
dpc-571	361	22	risk	risk	NOUN
dpc-571	361	23	of	of	ADP
dpc-571	361	24	occurrence	occurrence	NOUN
dpc-571	361	25	of	of	ADP
dpc-571	361	26	other	other	ADJ
dpc-571	361	27	neoplasia	neoplasia	NOUN
dpc-571	361	28	.	.	PUNCT
dpc-571	362	1	int	int	NOUN
dpc-571	362	2	j	j	PROPN
dpc-571	362	3	cancer	cancer	NOUN
dpc-571	362	4	.	.	PUNCT
dpc-571	363	1	1999;83(4):441	1999;83(4):441	NUM
dpc-571	363	2	-	-	PUNCT
dpc-571	363	3	448	448	NUM
dpc-571	363	4	.	.	PUNCT
dpc-571	364	1	42	42	NUM
dpc-571	364	2	.	.	PUNCT
dpc-571	365	1	borg	borg	PROPN
dpc-571	365	2	a	a	PROPN
dpc-571	365	3	,	,	PUNCT
dpc-571	365	4	sandberg	sandberg	PROPN
dpc-571	365	5	t	t	PROPN
dpc-571	365	6	,	,	PUNCT
dpc-571	365	7	nilsson	nilsson	PROPN
dpc-571	365	8	k	k	PROPN
dpc-571	365	9	,	,	PUNCT
dpc-571	365	10	et	et	PROPN
dpc-571	365	11	 	 	SPACE
dpc-571	365	12	al	al	PROPN
dpc-571	365	13	.	.	PROPN
dpc-571	365	14	high	high	ADJ
dpc-571	365	15	frequency	frequency	NOUN
dpc-571	365	16	of	of	ADP
dpc-571	365	17	multiple	multiple	ADJ
dpc-571	365	18	melanomas	melanoma	NOUN
dpc-571	365	19	and	and	CCONJ
dpc-571	365	20	breast	breast	NOUN
dpc-571	365	21	and	and	CCONJ
dpc-571	365	22	pancreas	pancrea	NOUN
dpc-571	365	23	carcinomas	carcinoma	NOUN
dpc-571	365	24	in	in	ADP
dpc-571	365	25	cdkn2a	cdkn2a	PROPN
dpc-571	365	26	mutation	mutation	NOUN
dpc-571	365	27	-	-	PUNCT
dpc-571	365	28	positive	positive	ADJ
dpc-571	365	29	melanoma	melanoma	NOUN
dpc-571	365	30	families	family	NOUN
dpc-571	365	31	.	.	PUNCT
dpc-571	366	1	j	j	PROPN
dpc-571	366	2	natl	natl	PROPN
dpc-571	366	3	cancer	cancer	PROPN
dpc-571	366	4	inst	inst	PROPN
dpc-571	366	5	.	.	PUNCT
dpc-571	367	1	2000;92(15):1260	2000;92(15):1260	NUM
dpc-571	367	2	-	-	SYM
dpc-571	367	3	1266	1266	NUM
dpc-571	367	4	.	.	PUNCT
dpc-571	368	1	43	43	NUM
dpc-571	368	2	.	.	PUNCT
dpc-571	369	1	vasen	vasen	PROPN
dpc-571	369	2	hf	hf	PROPN
dpc-571	369	3	,	,	PUNCT
dpc-571	369	4	gruis	gruis	ADJ
dpc-571	369	5	na	na	NOUN
dpc-571	369	6	,	,	PUNCT
dpc-571	369	7	frants	frants	PROPN
dpc-571	369	8	nn	nn	PROPN
dpc-571	369	9	,	,	PUNCT
dpc-571	369	10	et	et	PROPN
dpc-571	369	11	 	 	SPACE
dpc-571	369	12	al	al	PROPN
dpc-571	369	13	.	.	PROPN
dpc-571	369	14	risk	risk	NOUN
dpc-571	369	15	of	of	ADP
dpc-571	369	16	developing	develop	VERB
dpc-571	369	17	pancreatic	pancreatic	ADJ
dpc-571	369	18	cancer	cancer	NOUN
dpc-571	369	19	in	in	ADP
dpc-571	369	20	families	family	NOUN
dpc-571	369	21	with	with	ADP
dpc-571	369	22	familial	familial	ADJ
dpc-571	369	23	atypical	atypical	ADJ
dpc-571	369	24	multiple	multiple	ADJ
dpc-571	369	25	mole	mole	NOUN
dpc-571	369	26	melanoma	melanoma	NOUN
dpc-571	369	27	associated	associate	VERB
dpc-571	369	28	with	with	ADP
dpc-571	369	29	a	a	DET
dpc-571	369	30	specific	specific	ADJ
dpc-571	369	31	19	19	NUM
dpc-571	369	32	deletion	deletion	NOUN
dpc-571	369	33	of	of	ADP
dpc-571	369	34	p16	p16	NOUN
dpc-571	369	35	(	(	PUNCT
dpc-571	369	36	p16	p16	NOUN
dpc-571	369	37	-	-	PUNCT
dpc-571	369	38	leiden	leiden	NOUN
dpc-571	369	39	)	)	PUNCT
dpc-571	369	40	.	.	PUNCT
dpc-571	370	1	int	int	PROPN
dpc-571	370	2	j	j	PROPN
dpc-571	370	3	cancer	cancer	NOUN
dpc-571	370	4	.	.	PUNCT
dpc-571	371	1	2000;87(6):809	2000;87(6):809	NUM
dpc-571	371	2	-	-	PUNCT
dpc-571	371	3	811	811	NUM
dpc-571	371	4	.	.	PUNCT
dpc-571	372	1	44	44	NUM
dpc-571	372	2	.	.	PUNCT
dpc-571	373	1	rulyak	rulyak	NOUN
dpc-571	373	2	sj	sj	PROPN
dpc-571	373	3	,	,	PUNCT
dpc-571	373	4	brentnall	brentnall	NOUN
dpc-571	373	5	ta	ta	PROPN
dpc-571	373	6	,	,	PUNCT
dpc-571	373	7	lynch	lynch	PROPN
dpc-571	373	8	ht	ht	PROPN
dpc-571	373	9	,	,	PUNCT
dpc-571	373	10	austin	austin	PROPN
dpc-571	373	11	ma	ma	PROPN
dpc-571	373	12	.	.	PROPN
dpc-571	373	13	characterization	characterization	NOUN
dpc-571	373	14	of	of	ADP
dpc-571	373	15	the	the	DET
dpc-571	373	16	neoplastic	neoplastic	ADJ
dpc-571	373	17	phenotype	phenotype	NOUN
dpc-571	373	18	in	in	ADP
dpc-571	373	19	the	the	DET
dpc-571	373	20	familial	familial	ADJ
dpc-571	373	21	atypical	atypical	ADJ
dpc-571	373	22	multiple	multiple	ADJ
dpc-571	373	23	-	-	PUNCT
dpc-571	373	24	mole	mole	NOUN
dpc-571	373	25	melanoma	melanoma	NOUN
dpc-571	373	26	-	-	PUNCT
dpc-571	373	27	pancreatic	pancreatic	ADJ
dpc-571	373	28	carcinoma	carcinoma	NOUN
dpc-571	373	29	syndrome	syndrome	NOUN
dpc-571	373	30	.	.	PUNCT
dpc-571	374	1	cancer	cancer	NOUN
dpc-571	374	2	.	.	PUNCT
dpc-571	375	1	2003;98(4):798	2003;98(4):798	NUM
dpc-571	375	2	-	-	PUNCT
dpc-571	375	3	804	804	NUM
dpc-571	375	4	.	.	PUNCT
dpc-571	376	1	45	45	NUM
dpc-571	376	2	.	.	PUNCT
dpc-571	377	1	lynch	lynch	PROPN
dpc-571	377	2	ht	ht	PROPN
dpc-571	377	3	,	,	PUNCT
dpc-571	377	4	brand	brand	PROPN
dpc-571	377	5	re	re	PROPN
dpc-571	377	6	,	,	PUNCT
dpc-571	377	7	hogg	hogg	PROPN
dpc-571	377	8	d	d	PROPN
dpc-571	377	9	,	,	PUNCT
dpc-571	377	10	et	et	PROPN
dpc-571	377	11	 	 	SPACE
dpc-571	377	12	al	al	PROPN
dpc-571	377	13	.	.	PROPN
dpc-571	377	14	phenotypic	phenotypic	ADJ
dpc-571	377	15	variation	variation	NOUN
dpc-571	377	16	in	in	ADP
dpc-571	377	17	eight	eight	NUM
dpc-571	377	18	extended	extended	ADJ
dpc-571	377	19	cdkn2a	cdkn2a	PROPN
dpc-571	377	20	germline	germline	NOUN
dpc-571	377	21	mutation	mutation	NOUN
dpc-571	377	22	familial	familial	ADJ
dpc-571	377	23	atypical	atypical	ADJ
dpc-571	377	24	multiple	multiple	ADJ
dpc-571	377	25	mole	mole	NOUN
dpc-571	377	26	melanoma	melanoma	NOUN
dpc-571	377	27	-	-	PUNCT
dpc-571	377	28	pancreatic	pancreatic	ADJ
dpc-571	377	29	carcinoma	carcinoma	NOUN
dpc-571	377	30	syndrome	syndrome	NOUN
dpc-571	377	31	.	.	PUNCT
dpc-571	378	1	cancer	cancer	NOUN
dpc-571	378	2	.	.	PUNCT
dpc-571	379	1	2002;94(1):84–96	2002;94(1):84–96	X
dpc-571	379	2	.	.	PROPN
dpc-571	380	1	46	46	NUM
dpc-571	380	2	.	.	PUNCT
dpc-571	381	1	parker	parker	PROPN
dpc-571	381	2	jf	jf	PROPN
dpc-571	381	3	,	,	PUNCT
dpc-571	381	4	florell	florell	PROPN
dpc-571	381	5	sr	sr	PROPN
dpc-571	381	6	,	,	PUNCT
dpc-571	381	7	alexander	alexander	PROPN
dpc-571	381	8	a	a	PROPN
dpc-571	381	9	,	,	PUNCT
dpc-571	381	10	et	et	PROPN
dpc-571	381	11	 	 	SPACE
dpc-571	381	12	al	al	PROPN
dpc-571	381	13	.	.	PUNCT
dpc-571	381	14	pancreatic	pancreatic	ADJ
dpc-571	381	15	carcinoma	carcinoma	NOUN
dpc-571	381	16	surveillance	surveillance	NOUN
dpc-571	381	17	in	in	ADP
dpc-571	381	18	patients	patient	NOUN
dpc-571	381	19	with	with	ADP
dpc-571	381	20	familial	familial	ADJ
dpc-571	381	21	melanoma	melanoma	NOUN
dpc-571	381	22	.	.	PUNCT
dpc-571	382	1	arch	arch	ADJ
dpc-571	382	2	dermatol	dermatol	NOUN
dpc-571	382	3	.	.	PUNCT
dpc-571	383	1	2003;139(8):1019	2003;139(8):1019	NUM
dpc-571	383	2	-	-	SYM
dpc-571	383	3	1025	1025	NUM
dpc-571	383	4	.	.	PUNCT
dpc-571	384	1	47	47	NUM
dpc-571	384	2	.	.	PUNCT
dpc-571	385	1	molven	molven	VERB
dpc-571	385	2	a	a	PRON
dpc-571	385	3	,	,	PUNCT
dpc-571	385	4	grimstvedt	grimstvedt	PROPN
dpc-571	385	5	mb	mb	ADP
dpc-571	385	6	,	,	PUNCT
dpc-571	385	7	steine	steine	PROPN
dpc-571	385	8	sj	sj	PROPN
dpc-571	385	9	,	,	PUNCT
dpc-571	385	10	et	et	PROPN
dpc-571	385	11	 	 	SPACE
dpc-571	385	12	al	al	PROPN
dpc-571	385	13	.	.	PUNCT
dpc-571	386	1	a	a	DET
dpc-571	386	2	large	large	ADJ
dpc-571	386	3	norwegian	norwegian	ADJ
dpc-571	386	4	family	family	NOUN
dpc-571	386	5	with	with	ADP
dpc-571	386	6	inherited	inherit	VERB
dpc-571	386	7	malignant	malignant	ADJ
dpc-571	386	8	melanoma	melanoma	NOUN
dpc-571	386	9	,	,	PUNCT
dpc-571	386	10	multiple	multiple	ADJ
dpc-571	386	11	atypical	atypical	ADJ
dpc-571	386	12	nevi	nevi	NOUN
dpc-571	386	13	,	,	PUNCT
dpc-571	386	14	and	and	CCONJ
dpc-571	386	15	cdk4	cdk4	NOUN
dpc-571	386	16	mutation	mutation	NOUN
dpc-571	386	17	.	.	PUNCT
dpc-571	387	1	genes	gene	NOUN
dpc-571	387	2	chromosomes	chromosome	NOUN
dpc-571	387	3	cancer	cancer	NOUN
dpc-571	387	4	.	.	PUNCT
dpc-571	388	1	2005;44(1):10	2005;44(1):10	NUM
dpc-571	388	2	-	-	SYM
dpc-571	388	3	18	18	NUM
dpc-571	388	4	.	.	PUNCT
dpc-571	389	1	48	48	NUM
dpc-571	389	2	.	.	PUNCT
dpc-571	390	1	puntervoll	puntervoll	VERB
dpc-571	390	2	he	he	PRON
dpc-571	390	3	,	,	PUNCT
dpc-571	390	4	yang	yang	PROPN
dpc-571	390	5	xr	xr	PROPN
dpc-571	390	6	,	,	PUNCT
dpc-571	390	7	vetti	vetti	NOUN
dpc-571	390	8	hh	hh	PROPN
dpc-571	390	9	,	,	PUNCT
dpc-571	390	10	et	et	NOUN
dpc-571	390	11	 	 	SPACE
dpc-571	391	1	al	al	PROPN
dpc-571	391	2	.	.	PUNCT
dpc-571	391	3	melanoma	melanoma	PROPN
dpc-571	391	4	prone	prone	ADJ
dpc-571	391	5	families	family	NOUN
dpc-571	391	6	with	with	ADP
dpc-571	391	7	cdk4	cdk4	NOUN
dpc-571	391	8	germline	germline	NOUN
dpc-571	391	9	mutation	mutation	NOUN
dpc-571	391	10	:	:	PUNCT
dpc-571	391	11	phenotypic	phenotypic	ADJ
dpc-571	391	12	profile	profile	NOUN
dpc-571	391	13	and	and	CCONJ
dpc-571	391	14	associations	association	NOUN
dpc-571	391	15	with	with	ADP
dpc-571	391	16	mc1r	mc1r	PROPN
dpc-571	391	17	variants	variant	NOUN
dpc-571	391	18	.	.	PUNCT
dpc-571	392	1	med	med	ADJ
dpc-571	392	2	genet	genet	NOUN
dpc-571	392	3	.	.	PUNCT
dpc-571	393	1	2013;50(4):264	2013;50(4):264	NUM
dpc-571	393	2	-	-	SYM
dpc-571	393	3	270	270	NUM
dpc-571	393	4	.	.	PUNCT
dpc-571	393	5	49	49	NUM
dpc-571	393	6	.	.	PUNCT
dpc-571	393	7	aoude	aoude	PROPN
dpc-571	393	8	lg	lg	PROPN
dpc-571	393	9	,	,	PUNCT
dpc-571	393	10	wadt	wadt	PROPN
dpc-571	393	11	k	k	PROPN
dpc-571	393	12	,	,	PUNCT
dpc-571	393	13	bojesen	bojesen	VERB
dpc-571	393	14	a	a	PRON
dpc-571	393	15	,	,	PUNCT
dpc-571	393	16	et	et	PROPN
dpc-571	393	17	 	 	SPACE
dpc-571	393	18	al	al	PROPN
dpc-571	393	19	.	.	PUNCT
dpc-571	394	1	a	a	DET
dpc-571	394	2	bap1	bap1	PROPN
dpc-571	394	3	mutation	mutation	NOUN
dpc-571	394	4	in	in	ADP
dpc-571	394	5	a	a	DET
dpc-571	394	6	danish	danish	ADJ
dpc-571	394	7	family	family	NOUN
dpc-571	394	8	predisposes	predispose	NOUN
dpc-571	394	9	to	to	PART
dpc-571	394	10	uveal	uveal	VERB
dpc-571	394	11	melanoma	melanoma	NOUN
dpc-571	394	12	and	and	CCONJ
dpc-571	394	13	other	other	ADJ
dpc-571	394	14	cancers	cancer	NOUN
dpc-571	394	15	.	.	PUNCT
dpc-571	395	1	plos	plos	PROPN
dpc-571	395	2	one	one	NUM
dpc-571	395	3	.	.	PUNCT
dpc-571	396	1	2013;8(8):e72144	2013;8(8):e72144	NUM
dpc-571	396	2	.	.	PUNCT
dpc-571	397	1	50	50	NUM
dpc-571	397	2	.	.	X
dpc-571	398	1	abdel	abdel	PROPN
dpc-571	398	2	-	-	PUNCT
dpc-571	398	3	rahman	rahman	PROPN
dpc-571	398	4	mh	mh	PROPN
dpc-571	398	5	,	,	PUNCT
dpc-571	398	6	pilarski	pilarski	ADJ
dpc-571	398	7	r	r	NOUN
dpc-571	398	8	,	,	PUNCT
dpc-571	398	9	cebulla	cebulla	NOUN
dpc-571	398	10	cm	cm	PROPN
dpc-571	398	11	,	,	PUNCT
dpc-571	398	12	et	et	PROPN
dpc-571	398	13	 	 	SPACE
dpc-571	398	14	al	al	PROPN
dpc-571	398	15	.	.	PROPN
dpc-571	398	16	germline	germline	PROPN
dpc-571	398	17	bap1	bap1	PROPN
dpc-571	398	18	mutation	mutation	NOUN
dpc-571	398	19	predisposes	predispose	NOUN
dpc-571	398	20	to	to	PART
dpc-571	398	21	uveal	uveal	VERB
dpc-571	398	22	melanoma	melanoma	NOUN
dpc-571	398	23	,	,	PUNCT
dpc-571	398	24	lung	lung	NOUN
dpc-571	398	25	adenocarcinoma	adenocarcinoma	NOUN
dpc-571	398	26	,	,	PUNCT
dpc-571	398	27	meningioma	meningioma	NOUN
dpc-571	398	28	,	,	PUNCT
dpc-571	398	29	and	and	CCONJ
dpc-571	398	30	other	other	ADJ
dpc-571	398	31	cancers	cancer	NOUN
dpc-571	398	32	.	.	PUNCT
dpc-571	399	1	j	j	PROPN
dpc-571	399	2	med	med	PROPN
dpc-571	399	3	genet	genet	PROPN
dpc-571	399	4	.	.	PUNCT
dpc-571	400	1	2011;48(12):856859	2011;48(12):856859	NUM
dpc-571	400	2	.	.	NOUN
dpc-571	400	3	51	51	NUM
dpc-571	400	4	.	.	PUNCT
dpc-571	401	1	carbone	carbone	PROPN
dpc-571	401	2	m	m	PROPN
dpc-571	401	3	,	,	PUNCT
dpc-571	401	4	ferris	ferris	PROPN
dpc-571	401	5	lk	lk	PROPN
dpc-571	401	6	,	,	PUNCT
dpc-571	401	7	baumann	baumann	PROPN
dpc-571	401	8	f	f	PROPN
dpc-571	401	9	,	,	PUNCT
dpc-571	401	10	et	et	PROPN
dpc-571	401	11	 	 	SPACE
dpc-571	401	12	al	al	PROPN
dpc-571	401	13	.	.	PUNCT
dpc-571	401	14	bap1	bap1	PROPN
dpc-571	401	15	cancer	cancer	NOUN
dpc-571	401	16	syndrome	syndrome	NOUN
dpc-571	401	17	:	:	PUNCT
dpc-571	401	18	malignant	malignant	ADJ
dpc-571	401	19	mesothelioma	mesothelioma	NOUN
dpc-571	401	20	,	,	PUNCT
dpc-571	401	21	uveal	uveal	ADJ
dpc-571	401	22	and	and	CCONJ
dpc-571	401	23	cutaneous	cutaneous	ADJ
dpc-571	401	24	melanoma	melanoma	NOUN
dpc-571	401	25	,	,	PUNCT
dpc-571	401	26	and	and	CCONJ
dpc-571	401	27	mbaits	mbait	NOUN
dpc-571	401	28	.	.	PUNCT
dpc-571	402	1	j	j	PROPN
dpc-571	402	2	transl	transl	PROPN
dpc-571	402	3	med	med	PROPN
dpc-571	402	4	.	.	PUNCT
dpc-571	403	1	2012;10:179	2012;10:179	PROPN
dpc-571	403	2	.	.	PUNCT