id	sid	tid	token	lemma	pos
dpc-5918	1	1	dermatology	dermatology	NOUN
dpc-5918	1	2	:	:	PUNCT
dpc-5918	1	3	practical	practical	ADJ
dpc-5918	1	4	and	and	CCONJ
dpc-5918	1	5	conceptual	conceptual	ADJ
dpc-5918	1	6	original	original	ADJ
dpc-5918	1	7	article	article	NOUN
dpc-5918	1	8	|	|	ADV
dpc-5918	1	9	dermatol	dermatol	ADJ
dpc-5918	1	10	pract	pract	NOUN
dpc-5918	1	11	concept	concept	NOUN
dpc-5918	1	12	.	.	PUNCT
dpc-5918	2	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	2	2	1	1	NUM
dpc-5918	2	3	grwd1	grwd1	NOUN
dpc-5918	2	4	drives	drive	VERB
dpc-5918	2	5	melanoma	melanoma	ADJ
dpc-5918	2	6	growth	growth	NOUN
dpc-5918	2	7	through	through	ADP
dpc-5918	2	8	nf	nf	ADJ
dpc-5918	2	9	-	-	PUNCT
dpc-5918	2	10	κb	κb	NOUN
dpc-5918	2	11	signaling	signal	VERB
dpc-5918	2	12	pathway	pathway	NOUN
dpc-5918	2	13	dursun	dursun	NOUN
dpc-5918	2	14	turkmen1	turkmen1	PROPN
dpc-5918	2	15	,	,	PUNCT
dpc-5918	2	16	rafet	rafet	VERB
dpc-5918	2	17	ozbey2	ozbey2	PROPN
dpc-5918	2	18	,	,	PUNCT
dpc-5918	2	19	berna	berna	PROPN
dpc-5918	2	20	ozdem3	ozdem3	PROPN
dpc-5918	2	21	,	,	PUNCT
dpc-5918	2	22	saadet	saadet	PROPN
dpc-5918	2	23	alan4	alan4	PROPN
dpc-5918	2	24	,	,	PUNCT
dpc-5918	2	25	ayten	ayten	VERB
dpc-5918	2	26	kilincli	kilincli	PROPN
dpc-5918	2	27	cetin3	cetin3	PROPN
dpc-5918	2	28	,	,	PUNCT
dpc-5918	2	29	fatma	fatma	PROPN
dpc-5918	2	30	bengisu	bengisu	PROPN
dpc-5918	2	31	baran1	baran1	PROPN
dpc-5918	2	32	,	,	PUNCT
dpc-5918	2	33	berat	berat	PROPN
dpc-5918	2	34	dogan5	dogan5	PROPN
dpc-5918	2	35	,	,	PUNCT
dpc-5918	2	36	nihal	nihal	PROPN
dpc-5918	2	37	altunisik1	altunisik1	PROPN
dpc-5918	2	38	,	,	PUNCT
dpc-5918	2	39	zekiye	zekiye	PROPN
dpc-5918	2	40	kanat1	kanat1	PROPN
dpc-5918	2	41	,	,	PUNCT
dpc-5918	2	42	serpil	serpil	VERB
dpc-5918	2	43	sener1	sener1	PROPN
dpc-5918	2	44	,	,	PUNCT
dpc-5918	2	45	ibrahim	ibrahim	PROPN
dpc-5918	2	46	tekedereli3	tekedereli3	NOUN
dpc-5918	3	1	1	1	NUM
dpc-5918	3	2	department	department	NOUN
dpc-5918	3	3	of	of	ADP
dpc-5918	3	4	dermatology	dermatology	NOUN
dpc-5918	3	5	,	,	PUNCT
dpc-5918	3	6	faculty	faculty	NOUN
dpc-5918	3	7	of	of	ADP
dpc-5918	3	8	medicine	medicine	NOUN
dpc-5918	3	9	,	,	PUNCT
dpc-5918	3	10	inonu	inonu	ADJ
dpc-5918	3	11	university	university	NOUN
dpc-5918	3	12	,	,	PUNCT
dpc-5918	3	13	malatya	malatya	PROPN
dpc-5918	3	14	,	,	PUNCT
dpc-5918	3	15	türkiye	türkiye	PROPN
dpc-5918	3	16	2	2	NUM
dpc-5918	3	17	department	department	NOUN
dpc-5918	3	18	of	of	ADP
dpc-5918	3	19	plastic	plastic	ADJ
dpc-5918	3	20	and	and	CCONJ
dpc-5918	3	21	reconstructive	reconstructive	ADJ
dpc-5918	3	22	surgery	surgery	NOUN
dpc-5918	3	23	,	,	PUNCT
dpc-5918	3	24	faculty	faculty	NOUN
dpc-5918	3	25	of	of	ADP
dpc-5918	3	26	medicine	medicine	NOUN
dpc-5918	3	27	,	,	PUNCT
dpc-5918	3	28	inonu	inonu	ADJ
dpc-5918	3	29	university	university	NOUN
dpc-5918	3	30	,	,	PUNCT
dpc-5918	3	31	malatya	malatya	PROPN
dpc-5918	3	32	,	,	PUNCT
dpc-5918	3	33	türkiye	türkiye	PROPN
dpc-5918	3	34	3	3	NUM
dpc-5918	3	35	department	department	NOUN
dpc-5918	3	36	of	of	ADP
dpc-5918	3	37	medical	medical	ADJ
dpc-5918	3	38	genetics	genetic	NOUN
dpc-5918	3	39	,	,	PUNCT
dpc-5918	3	40	faculty	faculty	NOUN
dpc-5918	3	41	of	of	ADP
dpc-5918	3	42	medicine	medicine	NOUN
dpc-5918	3	43	,	,	PUNCT
dpc-5918	3	44	inonu	inonu	ADJ
dpc-5918	3	45	university	university	NOUN
dpc-5918	3	46	,	,	PUNCT
dpc-5918	3	47	malatya	malatya	PROPN
dpc-5918	3	48	,	,	PUNCT
dpc-5918	3	49	türkiye	türkiye	PROPN
dpc-5918	3	50	4	4	NUM
dpc-5918	3	51	department	department	NOUN
dpc-5918	3	52	of	of	ADP
dpc-5918	3	53	medical	medical	ADJ
dpc-5918	3	54	pathology	pathology	NOUN
dpc-5918	3	55	,	,	PUNCT
dpc-5918	3	56	faculty	faculty	NOUN
dpc-5918	3	57	of	of	ADP
dpc-5918	3	58	medicine	medicine	NOUN
dpc-5918	3	59	,	,	PUNCT
dpc-5918	3	60	inonu	inonu	ADJ
dpc-5918	3	61	university	university	NOUN
dpc-5918	3	62	,	,	PUNCT
dpc-5918	3	63	malatya	malatya	PROPN
dpc-5918	3	64	,	,	PUNCT
dpc-5918	3	65	türkiye	türkiye	PROPN
dpc-5918	3	66	5	5	NUM
dpc-5918	3	67	department	department	NOUN
dpc-5918	3	68	of	of	ADP
dpc-5918	3	69	biomedical	biomedical	ADJ
dpc-5918	3	70	engineering	engineering	NOUN
dpc-5918	3	71	,	,	PUNCT
dpc-5918	3	72	faculty	faculty	NOUN
dpc-5918	3	73	of	of	ADP
dpc-5918	3	74	engineering	engineering	NOUN
dpc-5918	3	75	,	,	PUNCT
dpc-5918	3	76	inonu	inonu	NOUN
dpc-5918	3	77	university	university	NOUN
dpc-5918	3	78	,	,	PUNCT
dpc-5918	3	79	malatya	malatya	PROPN
dpc-5918	3	80	,	,	PUNCT
dpc-5918	3	81	türkiye	türkiye	PROPN
dpc-5918	3	82	key	key	ADJ
dpc-5918	3	83	words	word	NOUN
dpc-5918	3	84	:	:	PUNCT
dpc-5918	3	85	melanoma	melanoma	NOUN
dpc-5918	3	86	,	,	PUNCT
dpc-5918	3	87	grwd1	grwd1	ADJ
dpc-5918	3	88	,	,	PUNCT
dpc-5918	3	89	nf	nf	NOUN
dpc-5918	3	90	-	-	PUNCT
dpc-5918	3	91	κb	κb	ADJ
dpc-5918	3	92	,	,	PUNCT
dpc-5918	3	93	tumor	tumor	NOUN
dpc-5918	3	94	progression	progression	NOUN
dpc-5918	3	95	,	,	PUNCT
dpc-5918	3	96	signaling	signal	VERB
dpc-5918	3	97	pathway	pathway	NOUN
dpc-5918	3	98	citation	citation	NOUN
dpc-5918	3	99	:	:	PUNCT
dpc-5918	3	100	turkmen	turkmen	PROPN
dpc-5918	3	101	d	d	PROPN
dpc-5918	3	102	,	,	PUNCT
dpc-5918	3	103	ozbey	ozbey	PROPN
dpc-5918	3	104	r	r	PROPN
dpc-5918	3	105	,	,	PUNCT
dpc-5918	3	106	ozdem	ozdem	PROPN
dpc-5918	3	107	b	b	PROPN
dpc-5918	3	108	,	,	PUNCT
dpc-5918	3	109	alan	alan	PROPN
dpc-5918	3	110	s	s	PROPN
dpc-5918	3	111	,	,	PUNCT
dpc-5918	3	112	kilincli	kilincli	PROPN
dpc-5918	3	113	cetin	cetin	VERB
dpc-5918	3	114	a	a	PRON
dpc-5918	3	115	,	,	PUNCT
dpc-5918	3	116	baran	baran	NOUN
dpc-5918	3	117	fb	fb	NOUN
dpc-5918	3	118	,	,	PUNCT
dpc-5918	3	119	dogan	dogan	PROPN
dpc-5918	3	120	b	b	PROPN
dpc-5918	3	121	,	,	PUNCT
dpc-5918	3	122	altunisik	altunisik	ADJ
dpc-5918	3	123	n	n	CCONJ
dpc-5918	3	124	,	,	PUNCT
dpc-5918	3	125	kanat	kanat	PROPN
dpc-5918	3	126	z	z	PROPN
dpc-5918	3	127	,	,	PUNCT
dpc-5918	3	128	sener	sener	NOUN
dpc-5918	3	129	s	s	PROPN
dpc-5918	3	130	,	,	PUNCT
dpc-5918	3	131	tekedereli	tekedereli	ADJ
dpc-5918	3	132	i.	i.	PROPN
dpc-5918	3	133	grwd1	grwd1	PROPN
dpc-5918	3	134	drives	drive	VERB
dpc-5918	3	135	melanoma	melanoma	ADJ
dpc-5918	3	136	growth	growth	NOUN
dpc-5918	3	137	through	through	ADP
dpc-5918	3	138	nf	nf	ADJ
dpc-5918	3	139	-	-	PUNCT
dpc-5918	3	140	κb	κb	NOUN
dpc-5918	3	141	signaling	signal	VERB
dpc-5918	3	142	pathway	pathway	NOUN
dpc-5918	3	143	.	.	PUNCT
dpc-5918	4	1	dermatol	dermatol	NOUN
dpc-5918	4	2	pract	pract	PROPN
dpc-5918	4	3	concept	concept	NOUN
dpc-5918	4	4	.	.	PUNCT
dpc-5918	5	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	5	2	.	.	PUNCT
dpc-5918	6	1	doi	doi	NOUN
dpc-5918	6	2	:	:	PUNCT
dpc-5918	6	3	https://doi.org/10.5826/dpc.1504a5918	https://doi.org/10.5826/dpc.1504a5918	PROPN
dpc-5918	6	4	accepted	accept	VERB
dpc-5918	6	5	:	:	PUNCT
dpc-5918	6	6	july	july	PROPN
dpc-5918	6	7	30	30	NUM
dpc-5918	6	8	,	,	PUNCT
dpc-5918	6	9	2025	2025	NUM
dpc-5918	6	10	;	;	PUNCT
dpc-5918	6	11	published	publish	VERB
dpc-5918	6	12	:	:	PUNCT
dpc-5918	7	1	october	october	PROPN
dpc-5918	7	2	2025	2025	NUM
dpc-5918	7	3	copyright	copyright	NOUN
dpc-5918	7	4	:	:	PUNCT
dpc-5918	7	5	©	©	PROPN
dpc-5918	7	6	2025	2025	NUM
dpc-5918	7	7	turkmen	turkman	NOUN
dpc-5918	7	8	et	et	PROPN
dpc-5918	7	9	al	al	PROPN
dpc-5918	7	10	.	.	PUNCT
dpc-5918	8	1	this	this	PRON
dpc-5918	8	2	is	be	AUX
dpc-5918	8	3	an	an	DET
dpc-5918	8	4	open	open	ADJ
dpc-5918	8	5	-	-	PUNCT
dpc-5918	8	6	access	access	NOUN
dpc-5918	8	7	article	article	NOUN
dpc-5918	8	8	distributed	distribute	VERB
dpc-5918	8	9	under	under	ADP
dpc-5918	8	10	the	the	DET
dpc-5918	8	11	terms	term	NOUN
dpc-5918	8	12	of	of	ADP
dpc-5918	8	13	the	the	DET
dpc-5918	8	14	creative	creative	ADJ
dpc-5918	8	15	commons	common	NOUN
dpc-5918	8	16	attributionnon	attributionnon	VERB
dpc-5918	8	17	commercial	commercial	ADJ
dpc-5918	8	18	license	license	NOUN
dpc-5918	8	19	(	(	PUNCT
dpc-5918	8	20	by	by	ADP
dpc-5918	8	21	-	-	PUNCT
dpc-5918	8	22	nc-4.0	nc-4.0	NOUN
dpc-5918	8	23	)	)	PUNCT
dpc-5918	8	24	,	,	PUNCT
dpc-5918	8	25	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
dpc-5918	8	26	,	,	PUNCT
dpc-5918	8	27	which	which	PRON
dpc-5918	8	28	permits	permit	VERB
dpc-5918	8	29	unrestricted	unrestricted	ADJ
dpc-5918	8	30	noncommercial	noncommercial	ADJ
dpc-5918	8	31	use	use	NOUN
dpc-5918	8	32	,	,	PUNCT
dpc-5918	8	33	distribution	distribution	NOUN
dpc-5918	8	34	,	,	PUNCT
dpc-5918	8	35	and	and	CCONJ
dpc-5918	8	36	reproduction	reproduction	NOUN
dpc-5918	8	37	in	in	ADP
dpc-5918	8	38	any	any	DET
dpc-5918	8	39	medium	medium	NOUN
dpc-5918	8	40	,	,	PUNCT
dpc-5918	8	41	provided	provide	VERB
dpc-5918	8	42	the	the	DET
dpc-5918	8	43	original	original	ADJ
dpc-5918	8	44	authors	author	NOUN
dpc-5918	8	45	and	and	CCONJ
dpc-5918	8	46	source	source	NOUN
dpc-5918	8	47	are	be	AUX
dpc-5918	8	48	credited	credit	VERB
dpc-5918	8	49	.	.	PUNCT
dpc-5918	9	1	funding	funding	NOUN
dpc-5918	9	2	:	:	PUNCT
dpc-5918	9	3	the	the	DET
dpc-5918	9	4	study	study	NOUN
dpc-5918	9	5	was	be	AUX
dpc-5918	9	6	supported	support	VERB
dpc-5918	9	7	by	by	ADP
dpc-5918	9	8	the	the	DET
dpc-5918	9	9	scientific	scientific	ADJ
dpc-5918	9	10	research	research	NOUN
dpc-5918	9	11	projects	project	NOUN
dpc-5918	9	12	coordination	coordination	NOUN
dpc-5918	9	13	unit	unit	NOUN
dpc-5918	9	14	of	of	ADP
dpc-5918	9	15	inonu	inonu	ADJ
dpc-5918	9	16	university	university	NOUN
dpc-5918	9	17	with	with	ADP
dpc-5918	9	18	the	the	DET
dpc-5918	9	19	project	project	NOUN
dpc-5918	9	20	code	code	NOUN
dpc-5918	9	21	tcd-2019	tcd-2019	NOUN
dpc-5918	9	22	-	-	PUNCT
dpc-5918	9	23	2018	2018	NUM
dpc-5918	9	24	.	.	PUNCT
dpc-5918	10	1	this	this	DET
dpc-5918	10	2	study	study	NOUN
dpc-5918	10	3	was	be	AUX
dpc-5918	10	4	approved	approve	VERB
dpc-5918	10	5	by	by	ADP
dpc-5918	10	6	clinical	clinical	ADJ
dpc-5918	10	7	research	research	NOUN
dpc-5918	10	8	ethics	ethic	NOUN
dpc-5918	10	9	committee	committee	PROPN
dpc-5918	10	10	of	of	ADP
dpc-5918	10	11	inonu	inonu	PROPN
dpc-5918	10	12	university	university	PROPN
dpc-5918	10	13	medical	medical	ADJ
dpc-5918	10	14	faculty	faculty	NOUN
dpc-5918	10	15	(	(	PUNCT
dpc-5918	10	16	2022/121	2022/121	NUM
dpc-5918	10	17	)	)	PUNCT
dpc-5918	10	18	.	.	PUNCT
dpc-5918	11	1	competing	compete	VERB
dpc-5918	11	2	interests	interest	NOUN
dpc-5918	11	3	:	:	PUNCT
dpc-5918	11	4	none	none	NOUN
dpc-5918	11	5	.	.	PUNCT
dpc-5918	12	1	authorship	authorship	NOUN
dpc-5918	12	2	:	:	PUNCT
dpc-5918	12	3	all	all	DET
dpc-5918	12	4	authors	author	NOUN
dpc-5918	12	5	have	have	AUX
dpc-5918	12	6	contributed	contribute	VERB
dpc-5918	12	7	significantly	significantly	ADV
dpc-5918	12	8	to	to	ADP
dpc-5918	12	9	this	this	DET
dpc-5918	12	10	publication	publication	NOUN
dpc-5918	12	11	.	.	PUNCT
dpc-5918	13	1	corresponding	correspond	VERB
dpc-5918	13	2	author	author	NOUN
dpc-5918	13	3	:	:	PUNCT
dpc-5918	13	4	dursun	dursun	NOUN
dpc-5918	13	5	turkmen	turkmen	PROPN
dpc-5918	13	6	,	,	PUNCT
dpc-5918	13	7	md	md	PROPN
dpc-5918	13	8	,	,	PUNCT
dpc-5918	13	9	department	department	PROPN
dpc-5918	13	10	of	of	ADP
dpc-5918	13	11	dermatology	dermatology	NOUN
dpc-5918	13	12	,	,	PUNCT
dpc-5918	13	13	faculty	faculty	NOUN
dpc-5918	13	14	of	of	ADP
dpc-5918	13	15	medicine	medicine	NOUN
dpc-5918	13	16	,	,	PUNCT
dpc-5918	13	17	inonu	inonu	ADJ
dpc-5918	13	18	university	university	NOUN
dpc-5918	13	19	,	,	PUNCT
dpc-5918	13	20	malatya	malatya	PROPN
dpc-5918	13	21	,	,	PUNCT
dpc-5918	13	22	türkiye	türkiye	PROPN
dpc-5918	13	23	.	.	PUNCT
dpc-5918	14	1	orcid	orcid	PROPN
dpc-5918	15	1	i	i	PRON
dpc-5918	15	2	d	d	NOUN
dpc-5918	15	3	:	:	PUNCT
dpc-5918	15	4	0000	0000	NUM
dpc-5918	15	5	-	-	PUNCT
dpc-5918	15	6	0001	0001	NUM
dpc-5918	15	7	-	-	PUNCT
dpc-5918	15	8	9076	9076	NUM
dpc-5918	15	9	-	-	PUNCT
dpc-5918	15	10	4669	4669	NUM
dpc-5918	15	11	.	.	PUNCT
dpc-5918	16	1	e	e	X
dpc-5918	16	2	-	-	NOUN
dpc-5918	16	3	mail	mail	NOUN
dpc-5918	16	4	:	:	PUNCT
dpc-5918	17	1	dursunturkmen@gmail.com	dursunturkmen@gmail.com	X
dpc-5918	17	2	introduction	introduction	NOUN
dpc-5918	17	3	:	:	PUNCT
dpc-5918	17	4	melanoma	melanoma	NOUN
dpc-5918	17	5	is	be	AUX
dpc-5918	17	6	an	an	DET
dpc-5918	17	7	aggressive	aggressive	ADJ
dpc-5918	17	8	skin	skin	NOUN
dpc-5918	17	9	cancer	cancer	NOUN
dpc-5918	17	10	with	with	ADP
dpc-5918	17	11	high	high	ADJ
dpc-5918	17	12	metastatic	metastatic	ADJ
dpc-5918	17	13	potential	potential	NOUN
dpc-5918	17	14	.	.	PUNCT
dpc-5918	18	1	the	the	DET
dpc-5918	18	2	oncogenic	oncogenic	ADJ
dpc-5918	18	3	protein	protein	NOUN
dpc-5918	18	4	grwd1	grwd1	NOUN
dpc-5918	18	5	has	have	AUX
dpc-5918	18	6	been	be	AUX
dpc-5918	18	7	implicated	implicate	VERB
dpc-5918	18	8	in	in	ADP
dpc-5918	18	9	various	various	ADJ
dpc-5918	18	10	cancer	cancer	NOUN
dpc-5918	18	11	types	type	NOUN
dpc-5918	18	12	,	,	PUNCT
dpc-5918	18	13	but	but	CCONJ
dpc-5918	18	14	its	its	PRON
dpc-5918	18	15	role	role	NOUN
dpc-5918	18	16	in	in	ADP
dpc-5918	18	17	melanoma	melanoma	NOUN
dpc-5918	18	18	remains	remain	VERB
dpc-5918	18	19	unclear	unclear	ADJ
dpc-5918	18	20	.	.	PUNCT
dpc-5918	19	1	objectives	objective	NOUN
dpc-5918	19	2	:	:	PUNCT
dpc-5918	19	3	to	to	PART
dpc-5918	19	4	examine	examine	VERB
dpc-5918	19	5	the	the	DET
dpc-5918	19	6	effects	effect	NOUN
dpc-5918	19	7	of	of	ADP
dpc-5918	19	8	grwd1	grwd1	NOUN
dpc-5918	19	9	knockdown	knockdown	NOUN
dpc-5918	19	10	on	on	ADP
dpc-5918	19	11	melanoma	melanoma	NOUN
dpc-5918	19	12	cell	cell	NOUN
dpc-5918	19	13	proliferation	proliferation	NOUN
dpc-5918	19	14	,	,	PUNCT
dpc-5918	19	15	apoptosis	apoptosis	NOUN
dpc-5918	19	16	,	,	PUNCT
dpc-5918	19	17	and	and	CCONJ
dpc-5918	19	18	migration	migration	NOUN
dpc-5918	19	19	and	and	CCONJ
dpc-5918	19	20	to	to	PART
dpc-5918	19	21	evaluate	evaluate	VERB
dpc-5918	19	22	its	its	PRON
dpc-5918	19	23	prognostic	prognostic	ADJ
dpc-5918	19	24	significance	significance	NOUN
dpc-5918	19	25	in	in	ADP
dpc-5918	19	26	melanoma	melanoma	NOUN
dpc-5918	19	27	patients	patient	NOUN
dpc-5918	19	28	.	.	PUNCT
dpc-5918	20	1	methods	method	NOUN
dpc-5918	20	2	:	:	PUNCT
dpc-5918	20	3	a	a	DET
dpc-5918	20	4	combination	combination	NOUN
dpc-5918	20	5	of	of	ADP
dpc-5918	20	6	in	in	ADP
dpc-5918	20	7	vitro	vitro	X
dpc-5918	20	8	and	and	CCONJ
dpc-5918	20	9	clinical	clinical	ADJ
dpc-5918	20	10	analyses	analysis	NOUN
dpc-5918	20	11	was	be	AUX
dpc-5918	20	12	performed	perform	VERB
dpc-5918	20	13	.	.	PUNCT
dpc-5918	21	1	a2058	a2058	NUM
dpc-5918	21	2	melanoma	melanoma	NOUN
dpc-5918	21	3	cells	cell	NOUN
dpc-5918	21	4	were	be	AUX
dpc-5918	21	5	treated	treat	VERB
dpc-5918	21	6	with	with	ADP
dpc-5918	21	7	grwd1	grwd1	ADJ
dpc-5918	21	8	-	-	PUNCT
dpc-5918	21	9	specific	specific	ADJ
dpc-5918	21	10	sirna	sirna	NOUN
dpc-5918	21	11	,	,	PUNCT
dpc-5918	21	12	and	and	CCONJ
dpc-5918	21	13	cell	cell	NOUN
dpc-5918	21	14	proliferation	proliferation	NOUN
dpc-5918	21	15	,	,	PUNCT
dpc-5918	21	16	apoptosis	apoptosis	NOUN
dpc-5918	21	17	,	,	PUNCT
dpc-5918	21	18	and	and	CCONJ
dpc-5918	21	19	migration	migration	NOUN
dpc-5918	21	20	assays	assay	NOUN
dpc-5918	21	21	were	be	AUX
dpc-5918	21	22	conducted	conduct	VERB
dpc-5918	21	23	.	.	PUNCT
dpc-5918	22	1	western	western	ADJ
dpc-5918	22	2	blotting	blotting	NOUN
dpc-5918	22	3	was	be	AUX
dpc-5918	22	4	used	use	VERB
dpc-5918	22	5	to	to	PART
dpc-5918	22	6	assess	assess	VERB
dpc-5918	22	7	alterations	alteration	NOUN
dpc-5918	22	8	in	in	ADP
dpc-5918	22	9	key	key	ADJ
dpc-5918	22	10	oncogenic	oncogenic	ADJ
dpc-5918	22	11	pathways	pathway	NOUN
dpc-5918	22	12	.	.	PUNCT
dpc-5918	23	1	additionally	additionally	ADV
dpc-5918	23	2	,	,	PUNCT
dpc-5918	23	3	clinical	clinical	ADJ
dpc-5918	23	4	tissue	tissue	NOUN
dpc-5918	23	5	samples	sample	NOUN
dpc-5918	23	6	from	from	ADP
dpc-5918	23	7	melanoma	melanoma	NOUN
dpc-5918	23	8	patients	patient	NOUN
dpc-5918	23	9	were	be	AUX
dpc-5918	23	10	analyzed	analyze	VERB
dpc-5918	23	11	for	for	ADP
dpc-5918	23	12	grwd1	grwd1	NOUN
dpc-5918	23	13	expression	expression	NOUN
dpc-5918	23	14	,	,	PUNCT
dpc-5918	23	15	and	and	CCONJ
dpc-5918	23	16	kaplan	kaplan	PROPN
dpc-5918	23	17	-	-	PUNCT
dpc-5918	23	18	meier	meier	PROPN
dpc-5918	23	19	survival	survival	NOUN
dpc-5918	23	20	analysis	analysis	NOUN
dpc-5918	23	21	was	be	AUX
dpc-5918	23	22	performed	perform	VERB
dpc-5918	23	23	to	to	PART
dpc-5918	23	24	determine	determine	VERB
dpc-5918	23	25	its	its	PRON
dpc-5918	23	26	prognostic	prognostic	ADJ
dpc-5918	23	27	value	value	NOUN
dpc-5918	23	28	.	.	PUNCT
dpc-5918	24	1	results	result	NOUN
dpc-5918	24	2	:	:	PUNCT
dpc-5918	24	3	grwd1	grwd1	NOUN
dpc-5918	24	4	was	be	AUX
dpc-5918	24	5	highly	highly	ADV
dpc-5918	24	6	expressed	express	VERB
dpc-5918	24	7	in	in	ADP
dpc-5918	24	8	melanoma	melanoma	NOUN
dpc-5918	24	9	cells	cell	NOUN
dpc-5918	24	10	.	.	PUNCT
dpc-5918	25	1	grwd1	grwd1	NOUN
dpc-5918	25	2	knockdown	knockdown	NOUN
dpc-5918	25	3	significantly	significantly	ADV
dpc-5918	25	4	reduced	reduce	VERB
dpc-5918	25	5	cell	cell	NOUN
dpc-5918	25	6	proliferation	proliferation	NOUN
dpc-5918	25	7	(	(	PUNCT
dpc-5918	25	8	by	by	ADP
dpc-5918	25	9	63	63	NUM
dpc-5918	25	10	%	%	NOUN
dpc-5918	25	11	)	)	PUNCT
dpc-5918	25	12	,	,	PUNCT
dpc-5918	25	13	impaired	impair	VERB
dpc-5918	25	14	colony	colony	NOUN
dpc-5918	25	15	formation	formation	NOUN
dpc-5918	25	16	,	,	PUNCT
dpc-5918	25	17	and	and	CCONJ
dpc-5918	25	18	induced	induce	VERB
dpc-5918	25	19	apoptosis	apoptosis	NOUN
dpc-5918	25	20	(	(	PUNCT
dpc-5918	25	21	cleaved	cleave	VERB
dpc-5918	25	22	caspase-3	caspase-3	NUM
dpc-5918	25	23	levels	level	NOUN
dpc-5918	25	24	abstract	abstract	ADJ
dpc-5918	25	25	2	2	NUM
dpc-5918	25	26	original	original	ADJ
dpc-5918	25	27	article	article	NOUN
dpc-5918	25	28	|	|	ADV
dpc-5918	25	29	dermatol	dermatol	ADJ
dpc-5918	25	30	pract	pract	NOUN
dpc-5918	25	31	concept	concept	NOUN
dpc-5918	25	32	.	.	PUNCT
dpc-5918	26	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	26	2	introduction	introduction	NOUN
dpc-5918	26	3	melanomas	melanoma	NOUN
dpc-5918	26	4	are	be	AUX
dpc-5918	26	5	malignant	malignant	ADJ
dpc-5918	26	6	skin	skin	NOUN
dpc-5918	26	7	tumors	tumor	NOUN
dpc-5918	26	8	originating	originate	VERB
dpc-5918	26	9	from	from	ADP
dpc-5918	26	10	melanocytes	melanocyte	NOUN
dpc-5918	26	11	[	[	X
dpc-5918	26	12	1,2	1,2	NUM
dpc-5918	26	13	]	]	PUNCT
dpc-5918	26	14	.	.	PUNCT
dpc-5918	27	1	these	these	DET
dpc-5918	27	2	tumors	tumor	NOUN
dpc-5918	27	3	can	can	AUX
dpc-5918	27	4	arise	arise	VERB
dpc-5918	27	5	in	in	ADP
dpc-5918	27	6	any	any	DET
dpc-5918	27	7	tissue	tissue	NOUN
dpc-5918	27	8	containing	contain	VERB
dpc-5918	27	9	melanocytes	melanocyte	NOUN
dpc-5918	27	10	,	,	PUNCT
dpc-5918	27	11	including	include	VERB
dpc-5918	27	12	the	the	DET
dpc-5918	27	13	skin	skin	NOUN
dpc-5918	27	14	,	,	PUNCT
dpc-5918	27	15	mucosa	mucosa	NOUN
dpc-5918	27	16	,	,	PUNCT
dpc-5918	27	17	conjunctiva	conjunctiva	NOUN
dpc-5918	27	18	,	,	PUNCT
dpc-5918	27	19	uvea	uvea	ADJ
dpc-5918	27	20	,	,	PUNCT
dpc-5918	27	21	and	and	CCONJ
dpc-5918	27	22	meninges	meninge	NOUN
dpc-5918	27	23	,	,	PUNCT
dpc-5918	27	24	with	with	ADP
dpc-5918	27	25	the	the	DET
dpc-5918	27	26	skin	skin	NOUN
dpc-5918	27	27	being	be	AUX
dpc-5918	27	28	the	the	DET
dpc-5918	27	29	most	most	ADV
dpc-5918	27	30	commonly	commonly	ADV
dpc-5918	27	31	affected	affect	VERB
dpc-5918	27	32	site	site	NOUN
dpc-5918	27	33	[	[	X
dpc-5918	27	34	2	2	NUM
dpc-5918	27	35	]	]	PUNCT
dpc-5918	27	36	.	.	PUNCT
dpc-5918	28	1	although	although	SCONJ
dpc-5918	28	2	melanomas	melanoma	NOUN
dpc-5918	28	3	constitute	constitute	VERB
dpc-5918	28	4	only	only	ADV
dpc-5918	28	5	4	4	NUM
dpc-5918	28	6	%	%	NOUN
dpc-5918	28	7	of	of	ADP
dpc-5918	28	8	all	all	DET
dpc-5918	28	9	skin	skin	NOUN
dpc-5918	28	10	cancers	cancer	NOUN
dpc-5918	28	11	,	,	PUNCT
dpc-5918	28	12	they	they	PRON
dpc-5918	28	13	account	account	VERB
dpc-5918	28	14	for	for	ADP
dpc-5918	28	15	75	75	NUM
dpc-5918	28	16	%	%	NOUN
dpc-5918	28	17	of	of	ADP
dpc-5918	28	18	skin	skin	NOUN
dpc-5918	28	19	cancer	cancer	NOUN
dpc-5918	28	20	-	-	PUNCT
dpc-5918	28	21	related	relate	VERB
dpc-5918	28	22	deaths	death	NOUN
dpc-5918	28	23	[	[	X
dpc-5918	28	24	3	3	NUM
dpc-5918	28	25	]	]	PUNCT
dpc-5918	28	26	.	.	PUNCT
dpc-5918	29	1	since	since	SCONJ
dpc-5918	29	2	the	the	DET
dpc-5918	29	3	1960s	1960	NOUN
dpc-5918	29	4	,	,	PUNCT
dpc-5918	29	5	the	the	DET
dpc-5918	29	6	incidence	incidence	NOUN
dpc-5918	29	7	of	of	ADP
dpc-5918	29	8	malignant	malignant	ADJ
dpc-5918	29	9	melanoma	melanoma	NOUN
dpc-5918	29	10	has	have	AUX
dpc-5918	29	11	been	be	AUX
dpc-5918	29	12	increasing	increase	VERB
dpc-5918	29	13	globally	globally	ADV
dpc-5918	29	14	in	in	ADP
dpc-5918	29	15	both	both	DET
dpc-5918	29	16	males	male	NOUN
dpc-5918	29	17	and	and	CCONJ
dpc-5918	29	18	females	female	NOUN
dpc-5918	29	19	,	,	PUNCT
dpc-5918	29	20	posing	pose	VERB
dpc-5918	29	21	a	a	DET
dpc-5918	29	22	significant	significant	ADJ
dpc-5918	29	23	socioeconomic	socioeconomic	ADJ
dpc-5918	29	24	burden	burden	NOUN
dpc-5918	29	25	[	[	X
dpc-5918	29	26	4,5	4,5	NUM
dpc-5918	29	27	]	]	PUNCT
dpc-5918	29	28	.	.	PUNCT
dpc-5918	30	1	in	in	ADP
dpc-5918	30	2	the	the	DET
dpc-5918	30	3	united	united	PROPN
dpc-5918	30	4	states	states	PROPN
dpc-5918	30	5	,	,	PUNCT
dpc-5918	30	6	melanoma	melanoma	NOUN
dpc-5918	30	7	ranks	rank	VERB
dpc-5918	30	8	as	as	ADP
dpc-5918	30	9	the	the	DET
dpc-5918	30	10	fifth	fifth	ADJ
dpc-5918	30	11	most	most	ADV
dpc-5918	30	12	common	common	ADJ
dpc-5918	30	13	cancer	cancer	NOUN
dpc-5918	30	14	among	among	ADP
dpc-5918	30	15	males	male	NOUN
dpc-5918	30	16	and	and	CCONJ
dpc-5918	30	17	the	the	DET
dpc-5918	30	18	sixth	sixth	ADJ
dpc-5918	30	19	most	most	ADV
dpc-5918	30	20	common	common	ADJ
dpc-5918	30	21	among	among	ADP
dpc-5918	30	22	females	female	NOUN
dpc-5918	30	23	[	[	X
dpc-5918	30	24	4	4	NUM
dpc-5918	30	25	]	]	PUNCT
dpc-5918	30	26	.	.	PUNCT
dpc-5918	31	1	unlike	unlike	ADP
dpc-5918	31	2	other	other	ADJ
dpc-5918	31	3	solid	solid	ADJ
dpc-5918	31	4	tumors	tumor	NOUN
dpc-5918	31	5	,	,	PUNCT
dpc-5918	31	6	it	it	PRON
dpc-5918	31	7	frequently	frequently	ADV
dpc-5918	31	8	affects	affect	VERB
dpc-5918	31	9	younger	young	ADJ
dpc-5918	31	10	and	and	CCONJ
dpc-5918	31	11	middle	middle	ADJ
dpc-5918	31	12	-	-	PUNCT
dpc-5918	31	13	aged	aged	ADJ
dpc-5918	31	14	individuals	individual	NOUN
dpc-5918	31	15	,	,	PUNCT
dpc-5918	31	16	with	with	ADP
dpc-5918	31	17	a	a	DET
dpc-5918	31	18	median	median	ADJ
dpc-5918	31	19	age	age	NOUN
dpc-5918	31	20	at	at	ADP
dpc-5918	31	21	diagnosis	diagnosis	NOUN
dpc-5918	31	22	of	of	ADP
dpc-5918	31	23	57	57	NUM
dpc-5918	31	24	years	year	NOUN
dpc-5918	31	25	[	[	X
dpc-5918	31	26	4	4	NUM
dpc-5918	31	27	]	]	PUNCT
dpc-5918	31	28	.	.	PUNCT
dpc-5918	32	1	melanoma	melanoma	NOUN
dpc-5918	32	2	pathogenesis	pathogenesis	NOUN
dpc-5918	32	3	is	be	AUX
dpc-5918	32	4	a	a	DET
dpc-5918	32	5	multifactorial	multifactorial	ADJ
dpc-5918	32	6	process	process	NOUN
dpc-5918	32	7	integrating	integrate	VERB
dpc-5918	32	8	genetic	genetic	ADJ
dpc-5918	32	9	and	and	CCONJ
dpc-5918	32	10	environmental	environmental	ADJ
dpc-5918	32	11	factors	factor	NOUN
dpc-5918	32	12	[	[	X
dpc-5918	32	13	3	3	NUM
dpc-5918	32	14	]	]	PUNCT
dpc-5918	32	15	.	.	PUNCT
dpc-5918	33	1	ultraviolet	ultraviolet	ADJ
dpc-5918	33	2	radiation	radiation	NOUN
dpc-5918	33	3	(	(	PUNCT
dpc-5918	33	4	uvr	uvr	NOUN
dpc-5918	33	5	)	)	PUNCT
dpc-5918	33	6	from	from	ADP
dpc-5918	33	7	natural	natural	ADJ
dpc-5918	33	8	or	or	CCONJ
dpc-5918	33	9	artificial	artificial	ADJ
dpc-5918	33	10	sources	source	NOUN
dpc-5918	33	11	is	be	AUX
dpc-5918	33	12	the	the	DET
dpc-5918	33	13	most	most	ADV
dpc-5918	33	14	significant	significant	ADJ
dpc-5918	33	15	environmental	environmental	ADJ
dpc-5918	33	16	risk	risk	NOUN
dpc-5918	33	17	factor	factor	NOUN
dpc-5918	33	18	.	.	PUNCT
dpc-5918	34	1	individuals	individual	NOUN
dpc-5918	34	2	with	with	ADP
dpc-5918	34	3	lighter	light	ADJ
dpc-5918	34	4	skin	skin	NOUN
dpc-5918	34	5	tones	tone	NOUN
dpc-5918	34	6	,	,	PUNCT
dpc-5918	34	7	characterized	characterize	VERB
dpc-5918	34	8	by	by	ADP
dpc-5918	34	9	lower	low	ADJ
dpc-5918	34	10	melanin	melanin	NOUN
dpc-5918	34	11	levels	level	NOUN
dpc-5918	34	12	,	,	PUNCT
dpc-5918	34	13	are	be	AUX
dpc-5918	34	14	more	more	ADV
dpc-5918	34	15	susceptible	susceptible	ADJ
dpc-5918	34	16	to	to	ADP
dpc-5918	34	17	sunburns	sunburn	NOUN
dpc-5918	34	18	,	,	PUNCT
dpc-5918	34	19	thus	thus	ADV
dpc-5918	34	20	increasing	increase	VERB
dpc-5918	34	21	their	their	PRON
dpc-5918	34	22	risk	risk	NOUN
dpc-5918	34	23	of	of	ADP
dpc-5918	34	24	malignant	malignant	ADJ
dpc-5918	34	25	melanoma	melanoma	NOUN
dpc-5918	34	26	.	.	PUNCT
dpc-5918	35	1	additionally	additionally	ADV
dpc-5918	35	2	,	,	PUNCT
dpc-5918	35	3	a	a	DET
dpc-5918	35	4	higher	high	ADJ
dpc-5918	35	5	number	number	NOUN
dpc-5918	35	6	of	of	ADP
dpc-5918	35	7	nevi	nevi	PROPN
dpc-5918	35	8	correlates	correlate	VERB
dpc-5918	35	9	with	with	ADP
dpc-5918	35	10	an	an	DET
dpc-5918	35	11	elevated	elevated	ADJ
dpc-5918	35	12	risk	risk	NOUN
dpc-5918	35	13	of	of	ADP
dpc-5918	35	14	developing	develop	VERB
dpc-5918	35	15	melanoma	melanoma	NOUN
dpc-5918	35	16	.	.	PUNCT
dpc-5918	36	1	a	a	DET
dpc-5918	36	2	family	family	NOUN
dpc-5918	36	3	history	history	NOUN
dpc-5918	36	4	of	of	ADP
dpc-5918	36	5	malignant	malignant	ADJ
dpc-5918	36	6	melanoma	melanoma	NOUN
dpc-5918	36	7	further	far	ADV
dpc-5918	36	8	amplifies	amplify	VERB
dpc-5918	36	9	this	this	DET
dpc-5918	36	10	risk	risk	NOUN
dpc-5918	36	11	,	,	PUNCT
dpc-5918	36	12	potentially	potentially	ADV
dpc-5918	36	13	due	due	ADJ
dpc-5918	36	14	to	to	ADP
dpc-5918	36	15	shared	share	VERB
dpc-5918	36	16	sun	sun	NOUN
dpc-5918	36	17	exposure	exposure	NOUN
dpc-5918	36	18	habits	habit	NOUN
dpc-5918	36	19	or	or	CCONJ
dpc-5918	36	20	hereditary	hereditary	ADJ
dpc-5918	36	21	genetic	genetic	ADJ
dpc-5918	36	22	mutations	mutation	NOUN
dpc-5918	36	23	[	[	X
dpc-5918	36	24	3	3	NUM
dpc-5918	36	25	]	]	PUNCT
dpc-5918	36	26	.	.	PUNCT
dpc-5918	37	1	early	early	ADJ
dpc-5918	37	2	-	-	PUNCT
dpc-5918	37	3	stage	stage	NOUN
dpc-5918	37	4	primary	primary	ADJ
dpc-5918	37	5	amelanotic	amelanotic	ADJ
dpc-5918	37	6	melanoma	melanoma	NOUN
dpc-5918	37	7	(	(	PUNCT
dpc-5918	37	8	am	be	AUX
dpc-5918	37	9	)	)	PUNCT
dpc-5918	37	10	or	or	CCONJ
dpc-5918	37	11	melanotic	melanotic	ADJ
dpc-5918	37	12	melanoma	melanoma	NOUN
dpc-5918	37	13	(	(	PUNCT
dpc-5918	37	14	mm	mm	NOUN
dpc-5918	37	15	)	)	PUNCT
dpc-5918	37	16	is	be	AUX
dpc-5918	37	17	generally	generally	ADV
dpc-5918	37	18	associated	associate	VERB
dpc-5918	37	19	with	with	ADP
dpc-5918	37	20	a	a	DET
dpc-5918	37	21	favorable	favorable	ADJ
dpc-5918	37	22	prognosis	prognosis	NOUN
dpc-5918	37	23	[	[	X
dpc-5918	37	24	6	6	NUM
dpc-5918	37	25	]	]	PUNCT
dpc-5918	37	26	.	.	PUNCT
dpc-5918	38	1	however	however	ADV
dpc-5918	38	2	,	,	PUNCT
dpc-5918	38	3	due	due	ADP
dpc-5918	38	4	to	to	ADP
dpc-5918	38	5	challenging	challenge	VERB
dpc-5918	38	6	anatomical	anatomical	ADJ
dpc-5918	38	7	locations	location	NOUN
dpc-5918	38	8	,	,	PUNCT
dpc-5918	38	9	most	most	ADJ
dpc-5918	38	10	am	be	AUX
dpc-5918	38	11	and	and	CCONJ
dpc-5918	38	12	mm	mm	NUM
dpc-5918	38	13	cases	case	NOUN
dpc-5918	38	14	are	be	AUX
dpc-5918	38	15	diagnosed	diagnose	VERB
dpc-5918	38	16	at	at	ADP
dpc-5918	38	17	advanced	advanced	ADJ
dpc-5918	38	18	or	or	CCONJ
dpc-5918	38	19	metastatic	metastatic	ADJ
dpc-5918	38	20	stages	stage	NOUN
dpc-5918	38	21	,	,	PUNCT
dpc-5918	38	22	leading	lead	VERB
dpc-5918	38	23	to	to	ADP
dpc-5918	38	24	poor	poor	ADJ
dpc-5918	38	25	prognosis	prognosis	NOUN
dpc-5918	38	26	and	and	CCONJ
dpc-5918	38	27	necessitating	necessitate	VERB
dpc-5918	38	28	systemic	systemic	ADJ
dpc-5918	38	29	therapies	therapy	NOUN
dpc-5918	38	30	,	,	PUNCT
dpc-5918	38	31	including	include	VERB
dpc-5918	38	32	chemotherapy	chemotherapy	NOUN
dpc-5918	38	33	,	,	PUNCT
dpc-5918	38	34	targeted	target	VERB
dpc-5918	38	35	therapies	therapy	NOUN
dpc-5918	38	36	,	,	PUNCT
dpc-5918	38	37	or	or	CCONJ
dpc-5918	38	38	immunotherapy	immunotherapy	NOUN
dpc-5918	38	39	[	[	X
dpc-5918	38	40	6	6	NUM
dpc-5918	38	41	]	]	PUNCT
dpc-5918	38	42	.	.	PUNCT
dpc-5918	39	1	the	the	DET
dpc-5918	39	2	five	five	NUM
dpc-5918	39	3	-	-	PUNCT
dpc-5918	39	4	year	year	NOUN
dpc-5918	39	5	survival	survival	NOUN
dpc-5918	39	6	rate	rate	NOUN
dpc-5918	39	7	for	for	ADP
dpc-5918	39	8	stage	stage	NOUN
dpc-5918	39	9	4	4	NUM
dpc-5918	39	10	cases	case	NOUN
dpc-5918	39	11	is	be	AUX
dpc-5918	39	12	reported	report	VERB
dpc-5918	39	13	to	to	PART
dpc-5918	39	14	be	be	AUX
dpc-5918	39	15	between	between	ADP
dpc-5918	39	16	15	15	NUM
dpc-5918	39	17	and	and	CCONJ
dpc-5918	39	18	20	20	NUM
dpc-5918	39	19	%	%	NOUN
dpc-5918	40	1	[	[	X
dpc-5918	40	2	7	7	NUM
dpc-5918	40	3	]	]	PUNCT
dpc-5918	40	4	.	.	PUNCT
dpc-5918	41	1	this	this	PRON
dpc-5918	41	2	underscores	underscore	VERB
dpc-5918	41	3	the	the	DET
dpc-5918	41	4	critical	critical	ADJ
dpc-5918	41	5	need	need	NOUN
dpc-5918	41	6	for	for	ADP
dpc-5918	41	7	novel	novel	ADJ
dpc-5918	41	8	treatment	treatment	NOUN
dpc-5918	41	9	strategies	strategy	NOUN
dpc-5918	41	10	,	,	PUNCT
dpc-5918	41	11	particularly	particularly	ADV
dpc-5918	41	12	for	for	ADP
dpc-5918	41	13	advanced	advanced	ADJ
dpc-5918	41	14	-	-	PUNCT
dpc-5918	41	15	stage	stage	NOUN
dpc-5918	41	16	melanoma	melanoma	NOUN
dpc-5918	41	17	.	.	PUNCT
dpc-5918	42	1	a	a	DET
dpc-5918	42	2	thorough	thorough	ADJ
dpc-5918	42	3	understanding	understanding	NOUN
dpc-5918	42	4	of	of	ADP
dpc-5918	42	5	the	the	DET
dpc-5918	42	6	molecular	molecular	ADJ
dpc-5918	42	7	underpinnings	underpinning	NOUN
dpc-5918	42	8	of	of	ADP
dpc-5918	42	9	the	the	DET
dpc-5918	42	10	disease	disease	NOUN
dpc-5918	42	11	is	be	AUX
dpc-5918	42	12	imperative	imperative	ADJ
dpc-5918	42	13	for	for	ADP
dpc-5918	42	14	the	the	DET
dpc-5918	42	15	development	development	NOUN
dpc-5918	42	16	of	of	ADP
dpc-5918	42	17	effective	effective	ADJ
dpc-5918	42	18	therapeutic	therapeutic	ADJ
dpc-5918	42	19	interventions	intervention	NOUN
dpc-5918	42	20	.	.	PUNCT
dpc-5918	43	1	ribosomal	ribosomal	NOUN
dpc-5918	43	2	/	/	SYM
dpc-5918	43	3	nucleolar	nucleolar	ADJ
dpc-5918	43	4	proteins	protein	NOUN
dpc-5918	43	5	constitute	constitute	VERB
dpc-5918	43	6	a	a	DET
dpc-5918	43	7	diverse	diverse	ADJ
dpc-5918	43	8	family	family	NOUN
dpc-5918	43	9	with	with	ADP
dpc-5918	43	10	various	various	ADJ
dpc-5918	43	11	biological	biological	ADJ
dpc-5918	43	12	functions	function	NOUN
dpc-5918	43	13	.	.	PUNCT
dpc-5918	44	1	while	while	SCONJ
dpc-5918	44	2	some	some	DET
dpc-5918	44	3	members	member	NOUN
dpc-5918	44	4	of	of	ADP
dpc-5918	44	5	this	this	DET
dpc-5918	44	6	protein	protein	NOUN
dpc-5918	44	7	family	family	NOUN
dpc-5918	44	8	exert	exert	VERB
dpc-5918	44	9	tumor	tumor	NOUN
dpc-5918	44	10	-	-	PUNCT
dpc-5918	44	11	suppressive	suppressive	ADJ
dpc-5918	44	12	effects	effect	NOUN
dpc-5918	44	13	,	,	PUNCT
dpc-5918	44	14	others	other	NOUN
dpc-5918	44	15	promote	promote	VERB
dpc-5918	44	16	tumorigenesis	tumorigenesis	NOUN
dpc-5918	44	17	by	by	ADP
dpc-5918	44	18	inhibiting	inhibit	VERB
dpc-5918	44	19	the	the	DET
dpc-5918	44	20	activity	activity	NOUN
dpc-5918	44	21	of	of	ADP
dpc-5918	44	22	tumorsuppressive	tumorsuppressive	ADJ
dpc-5918	44	23	ribosomal	ribosomal	NOUN
dpc-5918	44	24	/	/	SYM
dpc-5918	44	25	nucleolar	nucleolar	ADJ
dpc-5918	44	26	proteins	protein	NOUN
dpc-5918	44	27	[	[	X
dpc-5918	44	28	8	8	NUM
dpc-5918	44	29	]	]	PUNCT
dpc-5918	44	30	.	.	PUNCT
dpc-5918	45	1	the	the	DET
dpc-5918	45	2	glutamate	glutamate	NOUN
dpc-5918	45	3	-	-	PUNCT
dpc-5918	45	4	rich	rich	ADJ
dpc-5918	45	5	wd40	wd40	PROPN
dpc-5918	45	6	repeat	repeat	NOUN
dpc-5918	45	7	-	-	PUNCT
dpc-5918	45	8	containing	contain	VERB
dpc-5918	45	9	1	1	NUM
dpc-5918	45	10	(	(	PUNCT
dpc-5918	45	11	grwd1	grwd1	NOUN
dpc-5918	45	12	)	)	PUNCT
dpc-5918	45	13	protein	protein	NOUN
dpc-5918	45	14	,	,	PUNCT
dpc-5918	45	15	a	a	DET
dpc-5918	45	16	member	member	NOUN
dpc-5918	45	17	of	of	ADP
dpc-5918	45	18	this	this	DET
dpc-5918	45	19	family	family	NOUN
dpc-5918	45	20	,	,	PUNCT
dpc-5918	45	21	interacts	interact	VERB
dpc-5918	45	22	with	with	ADP
dpc-5918	45	23	rpl11	rpl11	NOUN
dpc-5918	45	24	,	,	PUNCT
dpc-5918	45	25	disrupting	disrupt	VERB
dpc-5918	45	26	its	its	PRON
dpc-5918	45	27	association	association	NOUN
dpc-5918	45	28	with	with	ADP
dpc-5918	45	29	mdm2	mdm2	PROPN
dpc-5918	45	30	,	,	PUNCT
dpc-5918	45	31	thereby	thereby	ADV
dpc-5918	45	32	facilitating	facilitate	VERB
dpc-5918	45	33	p53	p53	NOUN
dpc-5918	45	34	degradation	degradation	NOUN
dpc-5918	45	35	via	via	ADP
dpc-5918	45	36	ubiquitination	ubiquitination	NOUN
dpc-5918	45	37	[	[	X
dpc-5918	45	38	8,9	8,9	NUM
dpc-5918	45	39	]	]	PUNCT
dpc-5918	45	40	.	.	PUNCT
dpc-5918	46	1	this	this	DET
dpc-5918	46	2	mechanism	mechanism	NOUN
dpc-5918	46	3	significantly	significantly	ADV
dpc-5918	46	4	contributes	contribute	VERB
dpc-5918	46	5	to	to	ADP
dpc-5918	46	6	cancer	cancer	NOUN
dpc-5918	46	7	progression	progression	NOUN
dpc-5918	46	8	.	.	PUNCT
dpc-5918	47	1	these	these	DET
dpc-5918	47	2	findings	finding	NOUN
dpc-5918	47	3	suggest	suggest	VERB
dpc-5918	47	4	that	that	SCONJ
dpc-5918	47	5	grwd1	grwd1	NOUN
dpc-5918	47	6	is	be	AUX
dpc-5918	47	7	a	a	DET
dpc-5918	47	8	multifunctional	multifunctional	ADJ
dpc-5918	47	9	protein	protein	NOUN
dpc-5918	47	10	involved	involve	VERB
dpc-5918	47	11	in	in	ADP
dpc-5918	47	12	multiple	multiple	ADJ
dpc-5918	47	13	cellular	cellular	ADJ
dpc-5918	47	14	regulatory	regulatory	ADJ
dpc-5918	47	15	pathways	pathway	NOUN
dpc-5918	47	16	associated	associate	VERB
dpc-5918	47	17	with	with	ADP
dpc-5918	47	18	cell	cell	NOUN
dpc-5918	47	19	growth	growth	NOUN
dpc-5918	47	20	control	control	NOUN
dpc-5918	48	1	[	[	X
dpc-5918	48	2	9	9	NUM
dpc-5918	48	3	]	]	PUNCT
dpc-5918	48	4	.	.	PUNCT
dpc-5918	49	1	recent	recent	ADJ
dpc-5918	49	2	studies	study	NOUN
dpc-5918	49	3	have	have	AUX
dpc-5918	49	4	demonstrated	demonstrate	VERB
dpc-5918	49	5	that	that	SCONJ
dpc-5918	49	6	grwd1	grwd1	NOUN
dpc-5918	49	7	directly	directly	ADV
dpc-5918	49	8	interacts	interact	VERB
dpc-5918	49	9	with	with	ADP
dpc-5918	49	10	p53	p53	NOUN
dpc-5918	49	11	,	,	PUNCT
dpc-5918	49	12	suppressing	suppress	VERB
dpc-5918	49	13	its	its	PRON
dpc-5918	49	14	transcriptional	transcriptional	ADJ
dpc-5918	49	15	activity	activity	NOUN
dpc-5918	49	16	.	.	PUNCT
dpc-5918	50	1	additionally	additionally	ADV
dpc-5918	50	2	,	,	PUNCT
dpc-5918	50	3	elevated	elevated	ADJ
dpc-5918	50	4	grwd1	grwd1	NOUN
dpc-5918	50	5	expression	expression	NOUN
dpc-5918	50	6	has	have	AUX
dpc-5918	50	7	been	be	AUX
dpc-5918	50	8	correlated	correlate	VERB
dpc-5918	50	9	with	with	ADP
dpc-5918	50	10	poor	poor	ADJ
dpc-5918	50	11	prognosis	prognosis	NOUN
dpc-5918	50	12	in	in	ADP
dpc-5918	50	13	patients	patient	NOUN
dpc-5918	50	14	with	with	ADP
dpc-5918	50	15	certain	certain	ADJ
dpc-5918	50	16	cancer	cancer	NOUN
dpc-5918	50	17	types	type	NOUN
dpc-5918	50	18	[	[	X
dpc-5918	50	19	9	9	NUM
dpc-5918	50	20	]	]	PUNCT
dpc-5918	50	21	.	.	PUNCT
dpc-5918	51	1	these	these	DET
dpc-5918	51	2	findings	finding	NOUN
dpc-5918	51	3	support	support	VERB
dpc-5918	51	4	the	the	DET
dpc-5918	51	5	oncogenic	oncogenic	ADJ
dpc-5918	51	6	role	role	NOUN
dpc-5918	51	7	of	of	ADP
dpc-5918	51	8	grwd1	grwd1	NOUN
dpc-5918	51	9	,	,	PUNCT
dpc-5918	51	10	suggesting	suggest	VERB
dpc-5918	51	11	that	that	SCONJ
dpc-5918	51	12	its	its	PRON
dpc-5918	51	13	suppression	suppression	NOUN
dpc-5918	51	14	may	may	AUX
dpc-5918	51	15	inhibit	inhibit	VERB
dpc-5918	51	16	tumor	tumor	NOUN
dpc-5918	51	17	progression	progression	NOUN
dpc-5918	51	18	.	.	PUNCT
dpc-5918	52	1	nevertheless	nevertheless	ADV
dpc-5918	52	2	,	,	PUNCT
dpc-5918	52	3	further	further	ADJ
dpc-5918	52	4	investigations	investigation	NOUN
dpc-5918	52	5	are	be	AUX
dpc-5918	52	6	required	require	VERB
dpc-5918	52	7	to	to	PART
dpc-5918	52	8	elucidate	elucidate	VERB
dpc-5918	52	9	the	the	DET
dpc-5918	52	10	precise	precise	ADJ
dpc-5918	52	11	oncogenic	oncogenic	ADJ
dpc-5918	52	12	mechanisms	mechanism	NOUN
dpc-5918	52	13	of	of	ADP
dpc-5918	52	14	grwd1	grwd1	NOUN
dpc-5918	53	1	[	[	X
dpc-5918	53	2	10	10	NUM
dpc-5918	53	3	]	]	PUNCT
dpc-5918	53	4	.	.	PUNCT
dpc-5918	54	1	objectives	objective	VERB
dpc-5918	54	2	the	the	DET
dpc-5918	54	3	present	present	ADJ
dpc-5918	54	4	study	study	NOUN
dpc-5918	54	5	examined	examine	VERB
dpc-5918	54	6	the	the	DET
dpc-5918	54	7	effects	effect	NOUN
dpc-5918	54	8	of	of	ADP
dpc-5918	54	9	grwd1	grwd1	NOUN
dpc-5918	54	10	on	on	ADP
dpc-5918	54	11	cellular	cellular	ADJ
dpc-5918	54	12	processes	process	NOUN
dpc-5918	54	13	,	,	PUNCT
dpc-5918	54	14	including	include	VERB
dpc-5918	54	15	proliferation	proliferation	NOUN
dpc-5918	54	16	,	,	PUNCT
dpc-5918	54	17	cell	cell	NOUN
dpc-5918	54	18	cycle	cycle	NOUN
dpc-5918	54	19	regulation	regulation	NOUN
dpc-5918	54	20	,	,	PUNCT
dpc-5918	54	21	invasion	invasion	NOUN
dpc-5918	54	22	,	,	PUNCT
dpc-5918	54	23	and	and	CCONJ
dpc-5918	54	24	apoptosis	apoptosis	NOUN
dpc-5918	54	25	,	,	PUNCT
dpc-5918	54	26	in	in	ADP
dpc-5918	54	27	melanoma	melanoma	NOUN
dpc-5918	54	28	cancer	cancer	NOUN
dpc-5918	54	29	cell	cell	NOUN
dpc-5918	54	30	line	line	NOUN
dpc-5918	54	31	.	.	PUNCT
dpc-5918	55	1	furthermore	furthermore	ADV
dpc-5918	55	2	,	,	PUNCT
dpc-5918	55	3	grwd1	grwd1	NOUN
dpc-5918	55	4	expression	expression	NOUN
dpc-5918	55	5	was	be	AUX
dpc-5918	55	6	analyzed	analyze	VERB
dpc-5918	55	7	in	in	ADP
dpc-5918	55	8	melanoma	melanoma	NOUN
dpc-5918	55	9	tumor	tumor	NOUN
dpc-5918	55	10	samples	sample	NOUN
dpc-5918	55	11	obtained	obtain	VERB
dpc-5918	55	12	from	from	ADP
dpc-5918	55	13	patients	patient	NOUN
dpc-5918	55	14	,	,	PUNCT
dpc-5918	55	15	and	and	CCONJ
dpc-5918	55	16	its	its	PRON
dpc-5918	55	17	association	association	NOUN
dpc-5918	55	18	with	with	ADP
dpc-5918	55	19	survival	survival	NOUN
dpc-5918	55	20	rates	rate	NOUN
dpc-5918	55	21	,	,	PUNCT
dpc-5918	55	22	histological	histological	ADJ
dpc-5918	55	23	subtypes	subtype	NOUN
dpc-5918	55	24	,	,	PUNCT
dpc-5918	55	25	tumor	tumor	NOUN
dpc-5918	55	26	depth	depth	NOUN
dpc-5918	55	27	,	,	PUNCT
dpc-5918	55	28	and	and	CCONJ
dpc-5918	55	29	disease	disease	NOUN
dpc-5918	55	30	stage	stage	NOUN
dpc-5918	55	31	was	be	AUX
dpc-5918	55	32	assessed	assess	VERB
dpc-5918	55	33	.	.	PUNCT
dpc-5918	56	1	our	our	PRON
dpc-5918	56	2	findings	finding	NOUN
dpc-5918	56	3	suggest	suggest	VERB
dpc-5918	56	4	that	that	SCONJ
dpc-5918	56	5	grwd1	grwd1	NOUN
dpc-5918	56	6	is	be	AUX
dpc-5918	56	7	a	a	DET
dpc-5918	56	8	promising	promising	ADJ
dpc-5918	56	9	therapeutic	therapeutic	ADJ
dpc-5918	56	10	target	target	NOUN
dpc-5918	56	11	and	and	CCONJ
dpc-5918	56	12	prognostic	prognostic	ADJ
dpc-5918	56	13	biomarker	biomarker	NOUN
dpc-5918	56	14	in	in	ADP
dpc-5918	56	15	melanoma	melanoma	NOUN
dpc-5918	56	16	.	.	PUNCT
dpc-5918	57	1	methods	method	NOUN
dpc-5918	57	2	cell	cell	NOUN
dpc-5918	57	3	line	line	NOUN
dpc-5918	57	4	and	and	CCONJ
dpc-5918	57	5	reagents	reagent	NOUN
dpc-5918	57	6	the	the	DET
dpc-5918	57	7	human	human	ADJ
dpc-5918	57	8	melanoma	melanoma	NOUN
dpc-5918	57	9	cancer	cancer	NOUN
dpc-5918	57	10	cell	cell	NOUN
dpc-5918	57	11	line	line	NOUN
dpc-5918	57	12	a2058	a2058	NUM
dpc-5918	57	13	was	be	AUX
dpc-5918	57	14	commercially	commercially	ADV
dpc-5918	57	15	acquired	acquire	VERB
dpc-5918	57	16	from	from	ADP
dpc-5918	57	17	the	the	DET
dpc-5918	57	18	american	american	ADJ
dpc-5918	57	19	type	type	NOUN
dpc-5918	57	20	culture	culture	NOUN
dpc-5918	57	21	collection	collection	NOUN
dpc-5918	57	22	increased	increase	VERB
dpc-5918	57	23	by	by	ADP
dpc-5918	57	24	17.3	17.3	NUM
dpc-5918	57	25	%	%	NOUN
dpc-5918	57	26	)	)	PUNCT
dpc-5918	57	27	.	.	PUNCT
dpc-5918	58	1	migration	migration	NOUN
dpc-5918	58	2	capacity	capacity	NOUN
dpc-5918	58	3	decreased	decrease	VERB
dpc-5918	58	4	by	by	ADP
dpc-5918	58	5	70	70	NUM
dpc-5918	58	6	%	%	NOUN
dpc-5918	58	7	,	,	PUNCT
dpc-5918	58	8	and	and	CCONJ
dpc-5918	58	9	nf	nf	ADJ
dpc-5918	58	10	-	-	PUNCT
dpc-5918	58	11	κb	κb	NOUN
dpc-5918	58	12	pathway	pathway	NOUN
dpc-5918	58	13	activity	activity	NOUN
dpc-5918	58	14	was	be	AUX
dpc-5918	58	15	suppressed	suppress	VERB
dpc-5918	58	16	,	,	PUNCT
dpc-5918	58	17	leading	lead	VERB
dpc-5918	58	18	to	to	ADP
dpc-5918	58	19	reduced	reduced	ADJ
dpc-5918	58	20	expression	expression	NOUN
dpc-5918	58	21	of	of	ADP
dpc-5918	58	22	bcl-2	bcl-2	NOUN
dpc-5918	58	23	,	,	PUNCT
dpc-5918	58	24	src	src	NOUN
dpc-5918	58	25	,	,	PUNCT
dpc-5918	58	26	and	and	CCONJ
dpc-5918	58	27	mdm2	mdm2	PROPN
dpc-5918	58	28	,	,	PUNCT
dpc-5918	58	29	while	while	SCONJ
dpc-5918	58	30	stabilizing	stabilize	VERB
dpc-5918	58	31	p53	p53	NOUN
dpc-5918	58	32	.	.	PUNCT
dpc-5918	59	1	tcga	tcga	PROPN
dpc-5918	59	2	-	-	PUNCT
dpc-5918	59	3	based	base	VERB
dpc-5918	59	4	analyses	analysis	NOUN
dpc-5918	59	5	revealed	reveal	VERB
dpc-5918	59	6	that	that	SCONJ
dpc-5918	59	7	high	high	ADJ
dpc-5918	59	8	grwd1	grwd1	NOUN
dpc-5918	59	9	expression	expression	NOUN
dpc-5918	59	10	was	be	AUX
dpc-5918	59	11	significantly	significantly	ADV
dpc-5918	59	12	associated	associate	VERB
dpc-5918	59	13	with	with	ADP
dpc-5918	59	14	shorter	short	ADJ
dpc-5918	59	15	survival	survival	NOUN
dpc-5918	59	16	in	in	ADP
dpc-5918	59	17	metastatic	metastatic	ADJ
dpc-5918	59	18	melanoma	melanoma	NOUN
dpc-5918	59	19	cases	case	NOUN
dpc-5918	59	20	(	(	PUNCT
dpc-5918	59	21	p=0.00029	p=0.00029	PROPN
dpc-5918	59	22	)	)	PUNCT
dpc-5918	59	23	but	but	CCONJ
dpc-5918	59	24	showed	show	VERB
dpc-5918	59	25	no	no	DET
dpc-5918	59	26	correlation	correlation	NOUN
dpc-5918	59	27	with	with	ADP
dpc-5918	59	28	melanoma	melanoma	NOUN
dpc-5918	59	29	subtypes	subtype	NOUN
dpc-5918	59	30	.	.	PUNCT
dpc-5918	60	1	however	however	ADV
dpc-5918	60	2	,	,	PUNCT
dpc-5918	60	3	in	in	ADP
dpc-5918	60	4	immunohistochemical	immunohistochemical	ADJ
dpc-5918	60	5	analysis	analysis	NOUN
dpc-5918	60	6	of	of	ADP
dpc-5918	60	7	clinical	clinical	ADJ
dpc-5918	60	8	samples	sample	NOUN
dpc-5918	60	9	,	,	PUNCT
dpc-5918	60	10	no	no	DET
dpc-5918	60	11	statistically	statistically	ADV
dpc-5918	60	12	significant	significant	ADJ
dpc-5918	60	13	correlation	correlation	NOUN
dpc-5918	60	14	was	be	AUX
dpc-5918	60	15	found	find	VERB
dpc-5918	60	16	between	between	ADP
dpc-5918	60	17	grwd1	grwd1	NOUN
dpc-5918	60	18	staining	stain	VERB
dpc-5918	60	19	intensity	intensity	NOUN
dpc-5918	60	20	and	and	CCONJ
dpc-5918	60	21	survival	survival	NOUN
dpc-5918	60	22	.	.	PUNCT
dpc-5918	61	1	conclusions	conclusion	NOUN
dpc-5918	61	2	:	:	PUNCT
dpc-5918	61	3	grwd1	grwd1	NOUN
dpc-5918	61	4	plays	play	VERB
dpc-5918	61	5	a	a	DET
dpc-5918	61	6	crucial	crucial	ADJ
dpc-5918	61	7	role	role	NOUN
dpc-5918	61	8	in	in	ADP
dpc-5918	61	9	melanoma	melanoma	ADJ
dpc-5918	61	10	progression	progression	NOUN
dpc-5918	61	11	by	by	ADP
dpc-5918	61	12	enhancing	enhance	VERB
dpc-5918	61	13	nf	nf	ADJ
dpc-5918	61	14	-	-	PUNCT
dpc-5918	61	15	κb	κb	NOUN
dpc-5918	61	16	activity	activity	NOUN
dpc-5918	61	17	,	,	PUNCT
dpc-5918	61	18	promoting	promote	VERB
dpc-5918	61	19	proliferation	proliferation	NOUN
dpc-5918	61	20	,	,	PUNCT
dpc-5918	61	21	and	and	CCONJ
dpc-5918	61	22	suppressing	suppress	VERB
dpc-5918	61	23	apoptosis	apoptosis	NOUN
dpc-5918	61	24	.	.	PUNCT
dpc-5918	62	1	while	while	SCONJ
dpc-5918	62	2	high	high	ADJ
dpc-5918	62	3	grwd1	grwd1	NOUN
dpc-5918	62	4	expression	expression	NOUN
dpc-5918	62	5	is	be	AUX
dpc-5918	62	6	associated	associate	VERB
dpc-5918	62	7	with	with	ADP
dpc-5918	62	8	poor	poor	ADJ
dpc-5918	62	9	prognosis	prognosis	NOUN
dpc-5918	62	10	in	in	ADP
dpc-5918	62	11	public	public	ADJ
dpc-5918	62	12	datasets	dataset	NOUN
dpc-5918	62	13	,	,	PUNCT
dpc-5918	62	14	further	far	ADV
dpc-5918	62	15	clinical	clinical	ADJ
dpc-5918	62	16	validation	validation	NOUN
dpc-5918	62	17	with	with	ADP
dpc-5918	62	18	larger	large	ADJ
dpc-5918	62	19	patient	patient	NOUN
dpc-5918	62	20	cohorts	cohort	NOUN
dpc-5918	62	21	is	be	AUX
dpc-5918	62	22	needed	need	VERB
dpc-5918	62	23	to	to	PART
dpc-5918	62	24	confirm	confirm	VERB
dpc-5918	62	25	its	its	PRON
dpc-5918	62	26	utility	utility	NOUN
dpc-5918	62	27	as	as	ADP
dpc-5918	62	28	a	a	DET
dpc-5918	62	29	prognostic	prognostic	ADJ
dpc-5918	62	30	biomarker	biomarker	NOUN
dpc-5918	62	31	and	and	CCONJ
dpc-5918	62	32	therapeutic	therapeutic	ADJ
dpc-5918	62	33	target	target	NOUN
dpc-5918	62	34	.	.	PUNCT
dpc-5918	63	1	original	original	ADJ
dpc-5918	63	2	article	article	NOUN
dpc-5918	63	3	|	|	ADV
dpc-5918	63	4	dermatol	dermatol	ADJ
dpc-5918	63	5	pract	pract	NOUN
dpc-5918	63	6	concept	concept	NOUN
dpc-5918	63	7	.	.	PUNCT
dpc-5918	64	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	64	2	3	3	NUM
dpc-5918	64	3	(	(	PUNCT
dpc-5918	64	4	atcc	atcc	NOUN
dpc-5918	64	5	,	,	PUNCT
dpc-5918	64	6	usa	usa	PROPN
dpc-5918	64	7	)	)	PUNCT
dpc-5918	64	8	.	.	PUNCT
dpc-5918	65	1	grwd1	grwd1	PROPN
dpc-5918	65	2	sirna	sirna	PROPN
dpc-5918	65	3	was	be	AUX
dpc-5918	65	4	purchased	purchase	VERB
dpc-5918	65	5	from	from	ADP
dpc-5918	65	6	qiagen	qiagen	PROPN
dpc-5918	65	7	.	.	PUNCT
dpc-5918	66	1	the	the	DET
dpc-5918	66	2	culture	culture	NOUN
dpc-5918	66	3	medium	medium	NOUN
dpc-5918	66	4	dulbecco	dulbecco	NOUN
dpc-5918	66	5	's	's	PART
dpc-5918	66	6	minimal	minimal	ADJ
dpc-5918	66	7	essential	essential	ADJ
dpc-5918	66	8	medium	medium	NOUN
dpc-5918	66	9	(	(	PUNCT
dpc-5918	66	10	dmem	dmem	VERB
dpc-5918	66	11	high	high	ADJ
dpc-5918	66	12	glucose	glucose	NOUN
dpc-5918	66	13	)	)	PUNCT
dpc-5918	66	14	,	,	PUNCT
dpc-5918	66	15	fetal	fetal	ADJ
dpc-5918	66	16	bovine	bovine	NOUN
dpc-5918	66	17	serum	serum	NOUN
dpc-5918	66	18	(	(	PUNCT
dpc-5918	66	19	fbs	fbs	PROPN
dpc-5918	66	20	)	)	PUNCT
dpc-5918	66	21	,	,	PUNCT
dpc-5918	66	22	antibiotics	antibiotic	NOUN
dpc-5918	66	23	(	(	PUNCT
dpc-5918	66	24	penicillin	penicillin	NOUN
dpc-5918	66	25	and	and	CCONJ
dpc-5918	66	26	streptomycin	streptomycin	PROPN
dpc-5918	66	27	)	)	PUNCT
dpc-5918	66	28	,	,	PUNCT
dpc-5918	66	29	and	and	CCONJ
dpc-5918	66	30	l	l	NOUN
dpc-5918	66	31	-	-	NOUN
dpc-5918	66	32	glutamine	glutamine	NOUN
dpc-5918	66	33	(	(	PUNCT
dpc-5918	66	34	cat	cat	NOUN
dpc-5918	66	35	.	.	PUNCT
dpc-5918	67	1	no	no	PRON
dpc-5918	67	2	:	:	PUNCT
dpc-5918	67	3	25030	25030	NUM
dpc-5918	67	4	-	-	SYM
dpc-5918	67	5	081	081	NUM
dpc-5918	67	6	,	,	PUNCT
dpc-5918	67	7	gibco	gibco	NOUN
dpc-5918	67	8	)	)	PUNCT
dpc-5918	67	9	were	be	AUX
dpc-5918	67	10	obtained	obtain	VERB
dpc-5918	67	11	from	from	ADP
dpc-5918	67	12	gibco	gibco	PROPN
dpc-5918	67	13	(	(	PUNCT
dpc-5918	67	14	usa	usa	PROPN
dpc-5918	67	15	)	)	PUNCT
dpc-5918	67	16	with	with	ADP
dpc-5918	67	17	the	the	DET
dpc-5918	67	18	following	follow	VERB
dpc-5918	67	19	catalog	catalog	NOUN
dpc-5918	67	20	numbers	number	NOUN
dpc-5918	67	21	:	:	PUNCT
dpc-5918	67	22	dmem	dmem	VERB
dpc-5918	67	23	(	(	PUNCT
dpc-5918	67	24	11965084	11965084	NUM
dpc-5918	67	25	,	,	PUNCT
dpc-5918	67	26	thermofisher	thermofisher	PROPN
dpc-5918	67	27	,	,	PUNCT
dpc-5918	67	28	waltham	waltham	PROPN
dpc-5918	67	29	,	,	PUNCT
dpc-5918	67	30	ma	ma	PROPN
dpc-5918	67	31	,	,	PUNCT
dpc-5918	67	32	usa	usa	PROPN
dpc-5918	67	33	)	)	PUNCT
dpc-5918	67	34	and	and	CCONJ
dpc-5918	67	35	fbs	fbs	PROPN
dpc-5918	67	36	(	(	PUNCT
dpc-5918	67	37	p2442	p2442	PROPN
dpc-5918	67	38	,	,	PUNCT
dpc-5918	67	39	sigma	sigma	NOUN
dpc-5918	67	40	)	)	PUNCT
dpc-5918	67	41	.	.	PUNCT
dpc-5918	68	1	the	the	DET
dpc-5918	68	2	mts	mts	NOUN
dpc-5918	68	3	assay	assay	PROPN
dpc-5918	68	4	kit	kit	NOUN
dpc-5918	68	5	for	for	ADP
dpc-5918	68	6	cell	cell	NOUN
dpc-5918	68	7	proliferation	proliferation	NOUN
dpc-5918	68	8	was	be	AUX
dpc-5918	68	9	obtained	obtain	VERB
dpc-5918	68	10	from	from	ADP
dpc-5918	68	11	promega	promega	PROPN
dpc-5918	68	12	(	(	PUNCT
dpc-5918	68	13	cat	cat	NOUN
dpc-5918	68	14	.	.	PUNCT
dpc-5918	69	1	no	no	INTJ
dpc-5918	69	2	.	.	PUNCT
dpc-5918	70	1	g3582	g3582	NOUN
dpc-5918	70	2	)	)	PUNCT
dpc-5918	70	3	.	.	PUNCT
dpc-5918	71	1	bca	bca	PROPN
dpc-5918	71	2	protein	protein	NOUN
dpc-5918	71	3	assay	assay	NOUN
dpc-5918	71	4	kit	kit	NOUN
dpc-5918	71	5	(	(	PUNCT
dpc-5918	71	6	abcam	abcam	PROPN
dpc-5918	71	7	,	,	PUNCT
dpc-5918	71	8	cambridge	cambridge	PROPN
dpc-5918	71	9	,	,	PUNCT
dpc-5918	71	10	uk	uk	PROPN
dpc-5918	71	11	,	,	PUNCT
dpc-5918	71	12	cat	cat	NOUN
dpc-5918	71	13	.	.	PUNCT
dpc-5918	72	1	no	no	PRON
dpc-5918	72	2	:	:	PUNCT
dpc-5918	72	3	ab287853	ab287853	NOUN
dpc-5918	72	4	)	)	PUNCT
dpc-5918	72	5	were	be	AUX
dpc-5918	72	6	used	use	VERB
dpc-5918	72	7	.	.	PUNCT
dpc-5918	73	1	cell	cell	NOUN
dpc-5918	73	2	culture	culture	NOUN
dpc-5918	73	3	a2058	a2058	PROPN
dpc-5918	73	4	cells	cell	NOUN
dpc-5918	73	5	were	be	AUX
dpc-5918	73	6	cultured	cultured	ADJ
dpc-5918	73	7	in	in	ADP
dpc-5918	73	8	dmem	dmem	VERB
dpc-5918	73	9	high	high	ADJ
dpc-5918	73	10	glucose	glucose	NOUN
dpc-5918	73	11	supplemented	supplement	VERB
dpc-5918	73	12	with	with	ADP
dpc-5918	73	13	10	10	NUM
dpc-5918	73	14	%	%	NOUN
dpc-5918	73	15	fbs	fbs	ADJ
dpc-5918	73	16	,	,	PUNCT
dpc-5918	73	17	1	1	NUM
dpc-5918	73	18	%	%	NOUN
dpc-5918	73	19	penicillin	penicillin	NOUN
dpc-5918	73	20	-	-	PUNCT
dpc-5918	73	21	streptomycin	streptomycin	PROPN
dpc-5918	73	22	,	,	PUNCT
dpc-5918	73	23	and	and	CCONJ
dpc-5918	73	24	1	1	NUM
dpc-5918	73	25	%	%	NOUN
dpc-5918	73	26	l	l	NOUN
dpc-5918	73	27	-	-	NOUN
dpc-5918	73	28	glutamine	glutamine	NOUN
dpc-5918	73	29	in	in	ADP
dpc-5918	73	30	t25	t25	ADJ
dpc-5918	73	31	flasks	flask	NOUN
dpc-5918	73	32	at	at	ADP
dpc-5918	73	33	37	37	NUM
dpc-5918	73	34	°	°	ADP
dpc-5918	73	35	c	c	NOUN
dpc-5918	73	36	in	in	ADP
dpc-5918	73	37	a	a	DET
dpc-5918	73	38	humidified	humidify	VERB
dpc-5918	73	39	environment	environment	NOUN
dpc-5918	73	40	with	with	ADP
dpc-5918	73	41	5	5	NUM
dpc-5918	73	42	%	%	NOUN
dpc-5918	73	43	co	co	NOUN
dpc-5918	73	44	2	2	NUM
dpc-5918	73	45	.	.	PUNCT
dpc-5918	74	1	the	the	DET
dpc-5918	74	2	culture	culture	NOUN
dpc-5918	74	3	medium	medium	NOUN
dpc-5918	74	4	was	be	AUX
dpc-5918	74	5	replaced	replace	VERB
dpc-5918	74	6	every	every	DET
dpc-5918	74	7	48	48	NUM
dpc-5918	74	8	hours	hour	NOUN
dpc-5918	74	9	,	,	PUNCT
dpc-5918	74	10	and	and	CCONJ
dpc-5918	74	11	cells	cell	NOUN
dpc-5918	74	12	were	be	AUX
dpc-5918	74	13	subcultured	subculture	VERB
dpc-5918	74	14	upon	upon	SCONJ
dpc-5918	74	15	reaching	reach	VERB
dpc-5918	74	16	80	80	NUM
dpc-5918	74	17	%	%	NOUN
dpc-5918	74	18	confluency	confluency	NOUN
dpc-5918	74	19	.	.	PUNCT
dpc-5918	75	1	cell	cell	NOUN
dpc-5918	75	2	proliferation	proliferation	NOUN
dpc-5918	75	3	assay	assay	VERB
dpc-5918	75	4	grwd1	grwd1	PROPN
dpc-5918	75	5	knockdown	knockdown	NOUN
dpc-5918	75	6	was	be	AUX
dpc-5918	75	7	performed	perform	VERB
dpc-5918	75	8	via	via	ADP
dpc-5918	75	9	transient	transient	PROPN
dpc-5918	75	10	sirna	sirna	PROPN
dpc-5918	75	11	transfection	transfection	PROPN
dpc-5918	75	12	,	,	PUNCT
dpc-5918	75	13	and	and	CCONJ
dpc-5918	75	14	efficiency	efficiency	NOUN
dpc-5918	75	15	was	be	AUX
dpc-5918	75	16	confirmed	confirm	VERB
dpc-5918	75	17	72	72	NUM
dpc-5918	75	18	hours	hour	NOUN
dpc-5918	75	19	post	post	NOUN
dpc-5918	75	20	transfection	transfection	NOUN
dpc-5918	75	21	by	by	ADP
dpc-5918	75	22	western	western	ADJ
dpc-5918	75	23	blotting	blotting	NOUN
dpc-5918	75	24	.	.	PUNCT
dpc-5918	76	1	the	the	DET
dpc-5918	76	2	effect	effect	NOUN
dpc-5918	76	3	of	of	ADP
dpc-5918	76	4	grwd1	grwd1	PROPN
dpc-5918	76	5	sirna	sirna	PROPN
dpc-5918	76	6	on	on	ADP
dpc-5918	76	7	tumor	tumor	NOUN
dpc-5918	76	8	cell	cell	NOUN
dpc-5918	76	9	proliferation	proliferation	NOUN
dpc-5918	76	10	was	be	AUX
dpc-5918	76	11	evaluated	evaluate	VERB
dpc-5918	76	12	using	use	VERB
dpc-5918	76	13	the	the	DET
dpc-5918	76	14	mts	mts	NOUN
dpc-5918	76	15	assay	assay	NOUN
dpc-5918	76	16	(	(	PUNCT
dpc-5918	76	17	3-(4,5	3-(4,5	PROPN
dpc-5918	76	18	-	-	PUNCT
dpc-5918	76	19	dimethylthiazol-2	dimethylthiazol-2	VERB
dpc-5918	76	20	-	-	PUNCT
dpc-5918	76	21	yl)-5-(3	yl)-5-(3	NOUN
dpc-5918	76	22	-	-	PUNCT
dpc-5918	76	23	carboxymethoxyphenyl	carboxymethoxyphenyl	ADJ
dpc-5918	76	24	)	)	PUNCT
dpc-5918	76	25	2-(4	2-(4	NUM
dpc-5918	76	26	-	-	PUNCT
dpc-5918	76	27	sulfophenyl)-2h	sulfophenyl)-2h	NOUN
dpc-5918	76	28	-	-	PUNCT
dpc-5918	76	29	tetrazolium	tetrazolium	NOUN
dpc-5918	76	30	)	)	PUNCT
dpc-5918	76	31	.	.	PUNCT
dpc-5918	77	1	cells	cell	NOUN
dpc-5918	77	2	were	be	AUX
dpc-5918	77	3	initially	initially	ADV
dpc-5918	77	4	seeded	seed	VERB
dpc-5918	77	5	in	in	ADP
dpc-5918	77	6	25	25	NUM
dpc-5918	77	7	cm²	cm²	ADP
dpc-5918	77	8	cell	cell	NOUN
dpc-5918	77	9	culture	culture	NOUN
dpc-5918	77	10	flasks	flask	NOUN
dpc-5918	77	11	and	and	CCONJ
dpc-5918	77	12	treated	treat	VERB
dpc-5918	77	13	with	with	ADP
dpc-5918	77	14	grwd1	grwd1	PROPN
dpc-5918	77	15	sirna	sirna	PROPN
dpc-5918	77	16	(	(	PUNCT
dpc-5918	77	17	75	75	NUM
dpc-5918	77	18	nm	nm	NOUN
dpc-5918	77	19	)	)	PUNCT
dpc-5918	77	20	or	or	CCONJ
dpc-5918	77	21	control	control	PROPN
dpc-5918	77	22	sirna	sirna	PROPN
dpc-5918	77	23	.	.	PUNCT
dpc-5918	78	1	after	after	ADP
dpc-5918	78	2	24	24	NUM
dpc-5918	78	3	hours	hour	NOUN
dpc-5918	78	4	of	of	ADP
dpc-5918	78	5	incubation	incubation	NOUN
dpc-5918	78	6	,	,	PUNCT
dpc-5918	78	7	the	the	DET
dpc-5918	78	8	cells	cell	NOUN
dpc-5918	78	9	were	be	AUX
dpc-5918	78	10	harvested	harvest	VERB
dpc-5918	78	11	and	and	CCONJ
dpc-5918	78	12	plated	plate	VERB
dpc-5918	78	13	into	into	ADP
dpc-5918	78	14	96	96	NUM
dpc-5918	78	15	-	-	PUNCT
dpc-5918	78	16	well	well	NOUN
dpc-5918	78	17	plates	plate	NOUN
dpc-5918	78	18	with	with	ADP
dpc-5918	78	19	equal	equal	ADJ
dpc-5918	78	20	cell	cell	NOUN
dpc-5918	78	21	distribution	distribution	NOUN
dpc-5918	78	22	per	per	ADP
dpc-5918	78	23	well	well	ADV
dpc-5918	78	24	in	in	ADP
dpc-5918	78	25	100	100	NUM
dpc-5918	78	26	µl	µl	NOUN
dpc-5918	78	27	of	of	ADP
dpc-5918	78	28	growth	growth	NOUN
dpc-5918	78	29	media	medium	NOUN
dpc-5918	78	30	.	.	PUNCT
dpc-5918	79	1	for	for	ADP
dpc-5918	79	2	proliferation	proliferation	NOUN
dpc-5918	79	3	assessment	assessment	NOUN
dpc-5918	79	4	,	,	PUNCT
dpc-5918	79	5	celltiter	celltiter	NOUN
dpc-5918	79	6	96	96	NUM
dpc-5918	79	7	aqueous	aqueous	ADJ
dpc-5918	79	8	one	one	NUM
dpc-5918	79	9	solution	solution	NOUN
dpc-5918	79	10	cell	cell	NOUN
dpc-5918	79	11	proliferation	proliferation	NOUN
dpc-5918	79	12	assay	assay	NOUN
dpc-5918	79	13	(	(	PUNCT
dpc-5918	79	14	promega	promega	PROPN
dpc-5918	79	15	kit	kit	PROPN
dpc-5918	79	16	)	)	PUNCT
dpc-5918	79	17	was	be	AUX
dpc-5918	79	18	used	use	VERB
dpc-5918	79	19	.	.	PUNCT
dpc-5918	80	1	25	25	NUM
dpc-5918	80	2	µl	µl	NOUN
dpc-5918	80	3	of	of	ADP
dpc-5918	80	4	mts	mts	NOUN
dpc-5918	80	5	labeling	labeling	NOUN
dpc-5918	80	6	reagent	reagent	NOUN
dpc-5918	80	7	was	be	AUX
dpc-5918	80	8	added	add	VERB
dpc-5918	80	9	to	to	ADP
dpc-5918	80	10	each	each	DET
dpc-5918	80	11	well	well	ADV
dpc-5918	80	12	and	and	CCONJ
dpc-5918	80	13	incubated	incubate	VERB
dpc-5918	80	14	in	in	ADP
dpc-5918	80	15	a	a	DET
dpc-5918	80	16	humidified	humidify	VERB
dpc-5918	80	17	environment	environment	NOUN
dpc-5918	80	18	at	at	ADP
dpc-5918	80	19	37	37	NUM
dpc-5918	80	20	°	°	ADP
dpc-5918	80	21	c	c	NOUN
dpc-5918	80	22	for	for	ADP
dpc-5918	80	23	two	two	NUM
dpc-5918	80	24	hours	hour	NOUN
dpc-5918	80	25	.	.	PUNCT
dpc-5918	81	1	absorbance	absorbance	NOUN
dpc-5918	81	2	was	be	AUX
dpc-5918	81	3	measured	measure	VERB
dpc-5918	81	4	at	at	ADP
dpc-5918	81	5	490	490	NUM
dpc-5918	81	6	nm	nm	NOUN
dpc-5918	81	7	using	use	VERB
dpc-5918	81	8	a	a	DET
dpc-5918	81	9	microplate	microplate	NOUN
dpc-5918	81	10	reader	reader	NOUN
dpc-5918	81	11	(	(	PUNCT
dpc-5918	81	12	e	e	NOUN
dpc-5918	81	13	-	-	NOUN
dpc-5918	81	14	max	max	NOUN
dpc-5918	81	15	plus	plus	CCONJ
dpc-5918	81	16	,	,	PUNCT
dpc-5918	81	17	molecular	molecular	ADJ
dpc-5918	81	18	devices	device	NOUN
dpc-5918	81	19	,	,	PUNCT
dpc-5918	81	20	usa	usa	PROPN
dpc-5918	81	21	)	)	PUNCT
dpc-5918	81	22	.	.	PUNCT
dpc-5918	82	1	colony	colony	NOUN
dpc-5918	82	2	formation	formation	NOUN
dpc-5918	82	3	assay	assay	VERB
dpc-5918	82	4	to	to	PART
dpc-5918	82	5	evaluate	evaluate	VERB
dpc-5918	82	6	long	long	ADJ
dpc-5918	82	7	-	-	PUNCT
dpc-5918	82	8	term	term	NOUN
dpc-5918	82	9	proliferative	proliferative	ADJ
dpc-5918	82	10	capacity	capacity	NOUN
dpc-5918	82	11	,	,	PUNCT
dpc-5918	82	12	cells	cell	NOUN
dpc-5918	82	13	were	be	AUX
dpc-5918	82	14	seeded	seed	VERB
dpc-5918	82	15	in	in	ADP
dpc-5918	82	16	6	6	NUM
dpc-5918	82	17	-	-	PUNCT
dpc-5918	82	18	well	well	NOUN
dpc-5918	82	19	plates	plate	NOUN
dpc-5918	82	20	at	at	ADP
dpc-5918	82	21	a	a	DET
dpc-5918	82	22	density	density	NOUN
dpc-5918	82	23	of	of	ADP
dpc-5918	82	24	3,000	3,000	NUM
dpc-5918	82	25	cells	cell	NOUN
dpc-5918	82	26	per	per	ADP
dpc-5918	82	27	well	well	ADV
dpc-5918	82	28	.	.	PUNCT
dpc-5918	83	1	the	the	DET
dpc-5918	83	2	following	following	ADJ
dpc-5918	83	3	day	day	NOUN
dpc-5918	83	4	,	,	PUNCT
dpc-5918	83	5	sirna	sirna	PROPN
dpc-5918	83	6	transfection	transfection	NOUN
dpc-5918	83	7	was	be	AUX
dpc-5918	83	8	performed	perform	VERB
dpc-5918	83	9	.	.	PUNCT
dpc-5918	84	1	the	the	DET
dpc-5918	84	2	medium	medium	NOUN
dpc-5918	84	3	was	be	AUX
dpc-5918	84	4	replaced	replace	VERB
dpc-5918	84	5	after	after	ADP
dpc-5918	84	6	24	24	NUM
dpc-5918	84	7	hours	hour	NOUN
dpc-5918	84	8	,	,	PUNCT
dpc-5918	84	9	and	and	CCONJ
dpc-5918	84	10	the	the	DET
dpc-5918	84	11	cells	cell	NOUN
dpc-5918	84	12	were	be	AUX
dpc-5918	84	13	maintained	maintain	VERB
dpc-5918	84	14	for	for	ADP
dpc-5918	84	15	seven	seven	NUM
dpc-5918	84	16	days	day	NOUN
dpc-5918	84	17	.	.	PUNCT
dpc-5918	85	1	a	a	DET
dpc-5918	85	2	second	second	ADJ
dpc-5918	85	3	sirna	sirna	PROPN
dpc-5918	85	4	treatment	treatment	NOUN
dpc-5918	85	5	was	be	AUX
dpc-5918	85	6	administered	administer	VERB
dpc-5918	85	7	,	,	PUNCT
dpc-5918	85	8	followed	follow	VERB
dpc-5918	85	9	by	by	ADP
dpc-5918	85	10	an	an	DET
dpc-5918	85	11	additional	additional	ADJ
dpc-5918	85	12	7	7	NUM
dpc-5918	85	13	-	-	PUNCT
dpc-5918	85	14	day	day	NOUN
dpc-5918	85	15	incubation	incubation	NOUN
dpc-5918	85	16	period	period	NOUN
dpc-5918	85	17	.	.	PUNCT
dpc-5918	86	1	on	on	ADP
dpc-5918	86	2	day	day	NOUN
dpc-5918	86	3	15	15	NUM
dpc-5918	86	4	,	,	PUNCT
dpc-5918	86	5	colonies	colony	NOUN
dpc-5918	86	6	were	be	AUX
dpc-5918	86	7	fixed	fix	VERB
dpc-5918	86	8	with	with	ADP
dpc-5918	86	9	methanol	methanol	NOUN
dpc-5918	86	10	(	(	PUNCT
dpc-5918	86	11	5	5	NUM
dpc-5918	86	12	min	min	NOUN
dpc-5918	86	13	)	)	PUNCT
dpc-5918	86	14	and	and	CCONJ
dpc-5918	86	15	stained	stain	VERB
dpc-5918	86	16	with	with	ADP
dpc-5918	86	17	0.5	0.5	NUM
dpc-5918	86	18	%	%	NOUN
dpc-5918	86	19	crystal	crystal	NOUN
dpc-5918	86	20	violet	violet	NOUN
dpc-5918	86	21	(	(	PUNCT
dpc-5918	86	22	sigma	sigma	PROPN
dpc-5918	86	23	-	-	PUNCT
dpc-5918	86	24	aldrich	aldrich	NOUN
dpc-5918	86	25	)	)	PUNCT
dpc-5918	86	26	for	for	ADP
dpc-5918	86	27	10	10	NUM
dpc-5918	86	28	minutes	minute	NOUN
dpc-5918	86	29	.	.	PUNCT
dpc-5918	87	1	colonies	colony	NOUN
dpc-5918	87	2	were	be	AUX
dpc-5918	87	3	quantified	quantify	VERB
dpc-5918	87	4	using	use	VERB
dpc-5918	87	5	imagej	imagej	ADJ
dpc-5918	87	6	software	software	NOUN
dpc-5918	87	7	.	.	PUNCT
dpc-5918	88	1	flow	flow	VERB
dpc-5918	88	2	cytometric	cytometric	ADJ
dpc-5918	88	3	analysis	analysis	NOUN
dpc-5918	88	4	annexin	annexin	NOUN
dpc-5918	88	5	v	v	NOUN
dpc-5918	88	6	-	-	PUNCT
dpc-5918	88	7	pi	pi	NOUN
dpc-5918	88	8	apoptosis	apoptosis	NOUN
dpc-5918	88	9	analysis	analysis	NOUN
dpc-5918	88	10	cells	cell	NOUN
dpc-5918	88	11	were	be	AUX
dpc-5918	88	12	seeded	seed	VERB
dpc-5918	88	13	in	in	ADP
dpc-5918	88	14	6	6	NUM
dpc-5918	88	15	-	-	PUNCT
dpc-5918	88	16	well	well	NOUN
dpc-5918	88	17	plates	plate	NOUN
dpc-5918	88	18	at	at	ADP
dpc-5918	88	19	a	a	DET
dpc-5918	88	20	density	density	NOUN
dpc-5918	88	21	of	of	ADP
dpc-5918	88	22	2	2	NUM
dpc-5918	88	23	×	×	NOUN
dpc-5918	88	24	105	105	NUM
dpc-5918	88	25	cells	cell	NOUN
dpc-5918	88	26	per	per	ADP
dpc-5918	88	27	well	well	ADV
dpc-5918	88	28	and	and	CCONJ
dpc-5918	88	29	treated	treat	VERB
dpc-5918	88	30	with	with	ADP
dpc-5918	88	31	grwd1	grwd1	PROPN
dpc-5918	88	32	sirna	sirna	PROPN
dpc-5918	88	33	.	.	PUNCT
dpc-5918	89	1	after	after	ADP
dpc-5918	89	2	24	24	NUM
dpc-5918	89	3	hours	hour	NOUN
dpc-5918	89	4	,	,	PUNCT
dpc-5918	89	5	fresh	fresh	ADJ
dpc-5918	89	6	growth	growth	NOUN
dpc-5918	89	7	media	medium	NOUN
dpc-5918	89	8	was	be	AUX
dpc-5918	89	9	added	add	VERB
dpc-5918	89	10	to	to	ADP
dpc-5918	89	11	the	the	DET
dpc-5918	89	12	wells	well	NOUN
dpc-5918	89	13	.	.	PUNCT
dpc-5918	90	1	following	follow	VERB
dpc-5918	90	2	an	an	DET
dpc-5918	90	3	additional	additional	ADJ
dpc-5918	90	4	48	48	NUM
dpc-5918	90	5	hours	hour	NOUN
dpc-5918	90	6	of	of	ADP
dpc-5918	90	7	incubation	incubation	NOUN
dpc-5918	90	8	(	(	PUNCT
dpc-5918	90	9	total	total	ADJ
dpc-5918	90	10	72	72	NUM
dpc-5918	90	11	hours	hour	NOUN
dpc-5918	90	12	)	)	PUNCT
dpc-5918	90	13	,	,	PUNCT
dpc-5918	90	14	cells	cell	NOUN
dpc-5918	90	15	were	be	AUX
dpc-5918	90	16	collected	collect	VERB
dpc-5918	90	17	via	via	ADP
dpc-5918	90	18	trypsinization	trypsinization	NOUN
dpc-5918	90	19	and	and	CCONJ
dpc-5918	90	20	centrifugation	centrifugation	NOUN
dpc-5918	90	21	(	(	PUNCT
dpc-5918	90	22	1500	1500	NUM
dpc-5918	90	23	rpm	rpm	NOUN
dpc-5918	90	24	,	,	PUNCT
dpc-5918	90	25	5	5	NUM
dpc-5918	90	26	min	min	NOUN
dpc-5918	90	27	)	)	PUNCT
dpc-5918	90	28	.	.	PUNCT
dpc-5918	91	1	apoptosis	apoptosis	NOUN
dpc-5918	91	2	was	be	AUX
dpc-5918	91	3	assessed	assess	VERB
dpc-5918	91	4	using	use	VERB
dpc-5918	91	5	the	the	DET
dpc-5918	91	6	annexin	annexin	NOUN
dpc-5918	91	7	v	v	ADP
dpc-5918	91	8	-	-	PUNCT
dpc-5918	91	9	pi	pi	NOUN
dpc-5918	91	10	apoptosis	apoptosis	NOUN
dpc-5918	91	11	detection	detection	NOUN
dpc-5918	91	12	kit	kit	NOUN
dpc-5918	91	13	(	(	PUNCT
dpc-5918	91	14	bd	bd	PROPN
dpc-5918	91	15	biosciences	bioscience	NOUN
dpc-5918	91	16	,	,	PUNCT
dpc-5918	91	17	cat	cat	NOUN
dpc-5918	91	18	.	.	PUNCT
dpc-5918	92	1	no	no	PRON
dpc-5918	92	2	:	:	PUNCT
dpc-5918	92	3	556547	556547	NUM
dpc-5918	92	4	)	)	PUNCT
dpc-5918	92	5	.	.	PUNCT
dpc-5918	93	1	samples	sample	NOUN
dpc-5918	93	2	were	be	AUX
dpc-5918	93	3	analyzed	analyze	VERB
dpc-5918	93	4	using	use	VERB
dpc-5918	93	5	a	a	DET
dpc-5918	93	6	beckman	beckman	PROPN
dpc-5918	93	7	coulter	coulter	PROPN
dpc-5918	93	8	cytoflex	cytoflex	PROPN
dpc-5918	93	9	flow	flow	PROPN
dpc-5918	93	10	cytometer	cytometer	NOUN
dpc-5918	93	11	(	(	PUNCT
dpc-5918	93	12	beckman	beckman	PROPN
dpc-5918	93	13	coulter	coulter	PROPN
dpc-5918	93	14	,	,	PUNCT
dpc-5918	93	15	usa	usa	PROPN
dpc-5918	93	16	)	)	PUNCT
dpc-5918	94	1	[	[	X
dpc-5918	94	2	11	11	NUM
dpc-5918	94	3	]	]	PUNCT
dpc-5918	94	4	.	.	PUNCT
dpc-5918	95	1	cell	cell	NOUN
dpc-5918	95	2	cycle	cycle	NOUN
dpc-5918	95	3	analysis	analysis	NOUN
dpc-5918	95	4	via	via	ADP
dpc-5918	95	5	propidium	propidium	NOUN
dpc-5918	95	6	iodide	iodide	NOUN
dpc-5918	95	7	(	(	PUNCT
dpc-5918	95	8	pi	pi	NOUN
dpc-5918	95	9	)	)	PUNCT
dpc-5918	95	10	staining	stain	VERB
dpc-5918	95	11	to	to	PART
dpc-5918	95	12	determine	determine	VERB
dpc-5918	95	13	the	the	DET
dpc-5918	95	14	effect	effect	NOUN
dpc-5918	95	15	of	of	ADP
dpc-5918	95	16	grwd1	grwd1	NOUN
dpc-5918	95	17	knockdown	knockdown	NOUN
dpc-5918	95	18	on	on	ADP
dpc-5918	95	19	the	the	DET
dpc-5918	95	20	cell	cell	NOUN
dpc-5918	95	21	cycle	cycle	NOUN
dpc-5918	95	22	,	,	PUNCT
dpc-5918	95	23	a2058	a2058	NUM
dpc-5918	95	24	cells	cell	NOUN
dpc-5918	95	25	(	(	PUNCT
dpc-5918	95	26	200,000	200,000	NUM
dpc-5918	95	27	per	per	ADP
dpc-5918	95	28	25	25	NUM
dpc-5918	95	29	cm²	cm²	ADP
dpc-5918	95	30	flask	flask	NOUN
dpc-5918	95	31	)	)	PUNCT
dpc-5918	95	32	were	be	AUX
dpc-5918	95	33	transfected	transfecte	VERB
dpc-5918	95	34	with	with	ADP
dpc-5918	95	35	grwd1	grwd1	PROPN
dpc-5918	95	36	sirna	sirna	PROPN
dpc-5918	95	37	.	.	PUNCT
dpc-5918	96	1	after	after	ADP
dpc-5918	96	2	24	24	NUM
dpc-5918	96	3	hours	hour	NOUN
dpc-5918	96	4	,	,	PUNCT
dpc-5918	96	5	fresh	fresh	ADJ
dpc-5918	96	6	growth	growth	NOUN
dpc-5918	96	7	media	medium	NOUN
dpc-5918	96	8	was	be	AUX
dpc-5918	96	9	added	add	VERB
dpc-5918	96	10	,	,	PUNCT
dpc-5918	96	11	and	and	CCONJ
dpc-5918	96	12	cells	cell	NOUN
dpc-5918	96	13	were	be	AUX
dpc-5918	96	14	further	far	ADV
dpc-5918	96	15	incubated	incubate	VERB
dpc-5918	96	16	for	for	ADP
dpc-5918	96	17	an	an	DET
dpc-5918	96	18	additional	additional	ADJ
dpc-5918	96	19	48	48	NUM
dpc-5918	96	20	hours	hour	NOUN
dpc-5918	96	21	(	(	PUNCT
dpc-5918	96	22	total	total	ADJ
dpc-5918	96	23	72	72	NUM
dpc-5918	96	24	hours	hour	NOUN
dpc-5918	96	25	)	)	PUNCT
dpc-5918	96	26	.	.	PUNCT
dpc-5918	97	1	cells	cell	NOUN
dpc-5918	97	2	were	be	AUX
dpc-5918	97	3	then	then	ADV
dpc-5918	97	4	harvested	harvest	VERB
dpc-5918	97	5	and	and	CCONJ
dpc-5918	97	6	fixed	fix	VERB
dpc-5918	97	7	in	in	ADP
dpc-5918	97	8	70	70	NUM
dpc-5918	97	9	%	%	NOUN
dpc-5918	97	10	ethanol	ethanol	NOUN
dpc-5918	97	11	at	at	ADP
dpc-5918	97	12	-20	-20	NUM
dpc-5918	97	13	°	°	PROPN
dpc-5918	97	14	c	c	NOUN
dpc-5918	97	15	overnight	overnight	ADV
dpc-5918	97	16	.	.	PUNCT
dpc-5918	98	1	the	the	DET
dpc-5918	98	2	following	following	ADJ
dpc-5918	98	3	day	day	NOUN
dpc-5918	98	4	,	,	PUNCT
dpc-5918	98	5	cells	cell	NOUN
dpc-5918	98	6	were	be	AUX
dpc-5918	98	7	stained	stain	VERB
dpc-5918	98	8	with	with	ADP
dpc-5918	98	9	propidium	propidium	NOUN
dpc-5918	98	10	iodide	iodide	NOUN
dpc-5918	98	11	(	(	PUNCT
dpc-5918	98	12	pi	pi	NOUN
dpc-5918	98	13	,	,	PUNCT
dpc-5918	98	14	biolegend	biolegend	NOUN
dpc-5918	98	15	,	,	PUNCT
dpc-5918	98	16	cat	cat	NOUN
dpc-5918	98	17	.	.	PUNCT
dpc-5918	99	1	no	no	PRON
dpc-5918	99	2	:	:	PUNCT
dpc-5918	99	3	421301	421301	NUM
dpc-5918	99	4	)	)	PUNCT
dpc-5918	100	1	and	and	CCONJ
dpc-5918	100	2	rnase	rnase	PROPN
dpc-5918	100	3	a	a	PRON
dpc-5918	100	4	(	(	PUNCT
dpc-5918	100	5	100	100	NUM
dpc-5918	100	6	µg	µg	ADJ
dpc-5918	100	7	/	/	SYM
dpc-5918	100	8	ml	ml	NOUN
dpc-5918	100	9	)	)	PUNCT
dpc-5918	100	10	for	for	ADP
dpc-5918	100	11	30	30	NUM
dpc-5918	100	12	minutes	minute	NOUN
dpc-5918	100	13	at	at	ADP
dpc-5918	100	14	37	37	NUM
dpc-5918	100	15	°	°	ADP
dpc-5918	100	16	c.	c.	NOUN
dpc-5918	100	17	the	the	DET
dpc-5918	100	18	cell	cell	NOUN
dpc-5918	100	19	cycle	cycle	NOUN
dpc-5918	100	20	phase	phase	NOUN
dpc-5918	100	21	distribution	distribution	NOUN
dpc-5918	100	22	was	be	AUX
dpc-5918	100	23	analyzed	analyze	VERB
dpc-5918	100	24	using	use	VERB
dpc-5918	100	25	a	a	DET
dpc-5918	100	26	beckman	beckman	PROPN
dpc-5918	100	27	coulter	coulter	PROPN
dpc-5918	100	28	cytoflex	cytoflex	PROPN
dpc-5918	100	29	flow	flow	PROPN
dpc-5918	100	30	cytometer	cytometer	NOUN
dpc-5918	100	31	(	(	PUNCT
dpc-5918	100	32	beckman	beckman	PROPN
dpc-5918	100	33	coulter	coulter	PROPN
dpc-5918	100	34	,	,	PUNCT
dpc-5918	100	35	usa	usa	PROPN
dpc-5918	100	36	)	)	PUNCT
dpc-5918	100	37	.	.	PUNCT
dpc-5918	101	1	caspase-3	caspase-3	NUM
dpc-5918	101	2	activation	activation	NOUN
dpc-5918	101	3	assay	assay	NOUN
dpc-5918	101	4	cells	cell	NOUN
dpc-5918	101	5	were	be	AUX
dpc-5918	101	6	seeded	seed	VERB
dpc-5918	101	7	in	in	ADP
dpc-5918	101	8	6	6	NUM
dpc-5918	101	9	-	-	PUNCT
dpc-5918	101	10	well	well	NOUN
dpc-5918	101	11	plates	plate	NOUN
dpc-5918	101	12	and	and	CCONJ
dpc-5918	101	13	transfected	transfecte	VERB
dpc-5918	101	14	with	with	ADP
dpc-5918	101	15	grwd1	grwd1	PROPN
dpc-5918	101	16	sirna	sirna	PROPN
dpc-5918	101	17	.	.	PUNCT
dpc-5918	102	1	after	after	ADP
dpc-5918	102	2	24	24	NUM
dpc-5918	102	3	hours	hour	NOUN
dpc-5918	102	4	,	,	PUNCT
dpc-5918	102	5	fresh	fresh	ADJ
dpc-5918	102	6	growth	growth	NOUN
dpc-5918	102	7	media	medium	NOUN
dpc-5918	102	8	was	be	AUX
dpc-5918	102	9	added	add	VERB
dpc-5918	102	10	,	,	PUNCT
dpc-5918	102	11	and	and	CCONJ
dpc-5918	102	12	cells	cell	NOUN
dpc-5918	102	13	were	be	AUX
dpc-5918	102	14	further	far	ADV
dpc-5918	102	15	incubated	incubate	VERB
dpc-5918	102	16	for	for	ADP
dpc-5918	102	17	an	an	DET
dpc-5918	102	18	additional	additional	ADJ
dpc-5918	102	19	48	48	NUM
dpc-5918	102	20	hours	hour	NOUN
dpc-5918	102	21	(	(	PUNCT
dpc-5918	102	22	total	total	ADJ
dpc-5918	102	23	72	72	NUM
dpc-5918	102	24	hours	hour	NOUN
dpc-5918	102	25	)	)	PUNCT
dpc-5918	102	26	.	.	PUNCT
dpc-5918	103	1	cells	cell	NOUN
dpc-5918	103	2	were	be	AUX
dpc-5918	103	3	then	then	ADV
dpc-5918	103	4	collected	collect	VERB
dpc-5918	103	5	via	via	ADP
dpc-5918	103	6	centrifugation	centrifugation	NOUN
dpc-5918	103	7	(	(	PUNCT
dpc-5918	103	8	500	500	NUM
dpc-5918	103	9	×	×	NOUN
dpc-5918	103	10	g	g	NOUN
dpc-5918	103	11	,	,	PUNCT
dpc-5918	103	12	5	5	NUM
dpc-5918	103	13	min	min	NOUN
dpc-5918	103	14	)	)	PUNCT
dpc-5918	103	15	,	,	PUNCT
dpc-5918	103	16	fixed	fix	VERB
dpc-5918	103	17	,	,	PUNCT
dpc-5918	103	18	and	and	CCONJ
dpc-5918	103	19	permeabilized	permeabilize	VERB
dpc-5918	103	20	using	use	VERB
dpc-5918	103	21	bd	bd	PROPN
dpc-5918	103	22	cytofix	cytofix	ADJ
dpc-5918	103	23	/	/	SYM
dpc-5918	103	24	cytoperm	cytoperm	NOUN
dpc-5918	103	25	buffer	buffer	NOUN
dpc-5918	103	26	at	at	ADP
dpc-5918	103	27	4	4	NUM
dpc-5918	103	28	°	°	NUM
dpc-5918	103	29	c	c	NOUN
dpc-5918	103	30	for	for	ADP
dpc-5918	103	31	20	20	NUM
dpc-5918	103	32	minutes	minute	NOUN
dpc-5918	103	33	.	.	PUNCT
dpc-5918	104	1	apoptosis	apoptosis	NOUN
dpc-5918	104	2	was	be	AUX
dpc-5918	104	3	assessed	assess	VERB
dpc-5918	104	4	using	use	VERB
dpc-5918	104	5	the	the	DET
dpc-5918	104	6	fitc	fitc	NOUN
dpc-5918	104	7	active	active	ADJ
dpc-5918	104	8	caspase-3	caspase-3	NUM
dpc-5918	104	9	apoptosis	apoptosis	NOUN
dpc-5918	104	10	kit	kit	NOUN
dpc-5918	104	11	(	(	PUNCT
dpc-5918	104	12	bd	bd	PROPN
dpc-5918	104	13	biosciences	bioscience	NOUN
dpc-5918	104	14	,	,	PUNCT
dpc-5918	104	15	cat	cat	NOUN
dpc-5918	104	16	.	.	PUNCT
dpc-5918	105	1	no	no	PRON
dpc-5918	105	2	:	:	PUNCT
dpc-5918	105	3	550480	550480	NUM
dpc-5918	105	4	)	)	PUNCT
dpc-5918	105	5	.	.	PUNCT
dpc-5918	106	1	for	for	ADP
dpc-5918	106	2	caspase-3	caspase-3	NUM
dpc-5918	106	3	detection	detection	NOUN
dpc-5918	106	4	,	,	PUNCT
dpc-5918	106	5	cells	cell	NOUN
dpc-5918	106	6	were	be	AUX
dpc-5918	106	7	stained	stain	VERB
dpc-5918	106	8	with	with	ADP
dpc-5918	106	9	fitc	fitc	NOUN
dpc-5918	106	10	-	-	PUNCT
dpc-5918	106	11	conjugated	conjugate	VERB
dpc-5918	106	12	active	active	ADJ
dpc-5918	106	13	caspase-3	caspase-3	NUM
dpc-5918	106	14	antibody	antibody	NOUN
dpc-5918	106	15	in	in	ADP
dpc-5918	106	16	the	the	DET
dpc-5918	106	17	dark	dark	NOUN
dpc-5918	106	18	for	for	ADP
dpc-5918	106	19	30	30	NUM
dpc-5918	106	20	minutes	minute	NOUN
dpc-5918	106	21	.	.	PUNCT
dpc-5918	107	1	data	datum	NOUN
dpc-5918	107	2	acquisition	acquisition	NOUN
dpc-5918	107	3	was	be	AUX
dpc-5918	107	4	performed	perform	VERB
dpc-5918	107	5	using	use	VERB
dpc-5918	107	6	a	a	DET
dpc-5918	107	7	beckman	beckman	PROPN
dpc-5918	107	8	coulter	coulter	PROPN
dpc-5918	107	9	cytoflex	cytoflex	PROPN
dpc-5918	107	10	flow	flow	PROPN
dpc-5918	107	11	cytometer	cytometer	NOUN
dpc-5918	107	12	(	(	PUNCT
dpc-5918	107	13	beckman	beckman	PROPN
dpc-5918	107	14	coulter	coulter	PROPN
dpc-5918	107	15	,	,	PUNCT
dpc-5918	107	16	usa	usa	PROPN
dpc-5918	107	17	)	)	PUNCT
dpc-5918	107	18	,	,	PUNCT
dpc-5918	107	19	and	and	CCONJ
dpc-5918	107	20	10,000	10,000	NUM
dpc-5918	107	21	events	event	NOUN
dpc-5918	107	22	per	per	ADP
dpc-5918	107	23	sample	sample	NOUN
dpc-5918	107	24	were	be	AUX
dpc-5918	107	25	analyzed	analyze	VERB
dpc-5918	107	26	.	.	PUNCT
dpc-5918	108	1	western	western	ADJ
dpc-5918	108	2	blotting	blotting	ADJ
dpc-5918	108	3	western	western	ADJ
dpc-5918	108	4	blotting	blotting	NOUN
dpc-5918	108	5	was	be	AUX
dpc-5918	108	6	performed	perform	VERB
dpc-5918	108	7	to	to	PART
dpc-5918	108	8	analyze	analyze	VERB
dpc-5918	108	9	grwd1	grwd1	NOUN
dpc-5918	108	10	expression	expression	NOUN
dpc-5918	108	11	and	and	CCONJ
dpc-5918	108	12	signaling	signal	VERB
dpc-5918	108	13	pathway	pathway	NOUN
dpc-5918	108	14	alterations	alteration	NOUN
dpc-5918	108	15	.	.	PUNCT
dpc-5918	109	1	this	this	DET
dpc-5918	109	2	method	method	NOUN
dpc-5918	109	3	was	be	AUX
dpc-5918	109	4	carried	carry	VERB
dpc-5918	109	5	out	out	ADP
dpc-5918	109	6	as	as	SCONJ
dpc-5918	109	7	described	describe	VERB
dpc-5918	109	8	elsewhere	elsewhere	ADV
dpc-5918	109	9	[	[	X
dpc-5918	109	10	12	12	NUM
dpc-5918	109	11	]	]	PUNCT
dpc-5918	109	12	.	.	PUNCT
dpc-5918	110	1	to	to	PART
dpc-5918	110	2	confirm	confirm	VERB
dpc-5918	110	3	knockdown	knockdown	NOUN
dpc-5918	110	4	efficiency	efficiency	NOUN
dpc-5918	110	5	,	,	PUNCT
dpc-5918	110	6	grwd1	grwd1	ADJ
dpc-5918	110	7	band	band	NOUN
dpc-5918	110	8	intensities	intensity	NOUN
dpc-5918	110	9	were	be	AUX
dpc-5918	110	10	quantified	quantify	VERB
dpc-5918	110	11	via	via	ADP
dpc-5918	110	12	densitometric	densitometric	ADJ
dpc-5918	110	13	analysis	analysis	NOUN
dpc-5918	110	14	using	use	VERB
dpc-5918	110	15	imagej	imagej	ADJ
dpc-5918	110	16	software	software	NOUN
dpc-5918	110	17	and	and	CCONJ
dpc-5918	110	18	normalized	normalize	VERB
dpc-5918	110	19	to	to	ADP
dpc-5918	110	20	β	β	NOUN
dpc-5918	110	21	-	-	PUNCT
dpc-5918	110	22	actin	actin	NOUN
dpc-5918	110	23	levels	level	NOUN
dpc-5918	110	24	.	.	PUNCT
dpc-5918	111	1	the	the	DET
dpc-5918	111	2	relative	relative	ADJ
dpc-5918	111	3	expression	expression	NOUN
dpc-5918	111	4	was	be	AUX
dpc-5918	111	5	used	use	VERB
dpc-5918	111	6	to	to	PART
dpc-5918	111	7	verify	verify	VERB
dpc-5918	111	8	the	the	DET
dpc-5918	111	9	silencing	silence	VERB
dpc-5918	111	10	efficiency	efficiency	NOUN
dpc-5918	111	11	at	at	ADP
dpc-5918	111	12	the	the	DET
dpc-5918	111	13	72	72	NUM
dpc-5918	111	14	-	-	PUNCT
dpc-5918	111	15	hour	hour	NOUN
dpc-5918	111	16	posttransfection	posttransfection	NOUN
dpc-5918	111	17	point	point	NOUN
dpc-5918	111	18	.	.	PUNCT
dpc-5918	112	1	after	after	ADP
dpc-5918	112	2	protein	protein	NOUN
dpc-5918	112	3	extraction	extraction	NOUN
dpc-5918	112	4	and	and	CCONJ
dpc-5918	112	5	quantification	quantification	NOUN
dpc-5918	112	6	,	,	PUNCT
dpc-5918	112	7	samples	sample	NOUN
dpc-5918	112	8	were	be	AUX
dpc-5918	112	9	separated	separate	VERB
dpc-5918	112	10	via	via	ADP
dpc-5918	112	11	sds	sds	NOUN
dpc-5918	112	12	-	-	PUNCT
dpc-5918	112	13	page	page	NOUN
dpc-5918	112	14	and	and	CCONJ
dpc-5918	112	15	transferred	transfer	VERB
dpc-5918	112	16	onto	onto	ADP
dpc-5918	112	17	pvdf	pvdf	PROPN
dpc-5918	112	18	membranes	membrane	NOUN
dpc-5918	112	19	.	.	PUNCT
dpc-5918	113	1	membranes	membrane	NOUN
dpc-5918	113	2	were	be	AUX
dpc-5918	113	3	incubated	incubate	VERB
dpc-5918	113	4	overnight	overnight	ADV
dpc-5918	113	5	at	at	ADP
dpc-5918	113	6	4	4	NUM
dpc-5918	113	7	°	°	NUM
dpc-5918	113	8	c	c	NOUN
dpc-5918	113	9	with	with	ADP
dpc-5918	113	10	primary	primary	ADJ
dpc-5918	113	11	antibodies	antibody	NOUN
dpc-5918	113	12	against	against	ADP
dpc-5918	113	13	grwd1	grwd1	NOUN
dpc-5918	113	14	(	(	PUNCT
dpc-5918	113	15	biolegend	biolegend	NOUN
dpc-5918	113	16	,	,	PUNCT
dpc-5918	113	17	cat	cat	NOUN
dpc-5918	113	18	.	.	PUNCT
dpc-5918	114	1	no	no	PRON
dpc-5918	114	2	:	:	PUNCT
dpc-5918	114	3	645702	645702	NUM
dpc-5918	114	4	)	)	PUNCT
dpc-5918	114	5	,	,	PUNCT
dpc-5918	114	6	bcl-2	bcl-2	X
dpc-5918	114	7	(	(	PUNCT
dpc-5918	114	8	elabscience	elabscience	NOUN
dpc-5918	114	9	,	,	PUNCT
dpc-5918	114	10	cat	cat	NOUN
dpc-5918	114	11	.	.	PUNCT
dpc-5918	115	1	no	no	INTJ
dpc-5918	115	2	:	:	PUNCT
dpc-5918	116	1	e	e	NOUN
dpc-5918	116	2	-	-	NOUN
dpc-5918	116	3	ab22004	ab22004	ADJ
dpc-5918	116	4	)	)	PUNCT
dpc-5918	116	5	,	,	PUNCT
dpc-5918	116	6	cleaved	cleaved	ADJ
dpc-5918	116	7	parp	parp	NOUN
dpc-5918	116	8	(	(	PUNCT
dpc-5918	116	9	cell	cell	NOUN
dpc-5918	116	10	signaling	signaling	NOUN
dpc-5918	116	11	,	,	PUNCT
dpc-5918	116	12	cat	cat	NOUN
dpc-5918	116	13	.	.	PUNCT
dpc-5918	117	1	no	no	PRON
dpc-5918	117	2	:	:	PUNCT
dpc-5918	117	3	d214	d214	PROPN
dpc-5918	117	4	,	,	PUNCT
dpc-5918	117	5	19f4	19f4	NUM
dpc-5918	117	6	)	)	PUNCT
dpc-5918	117	7	,	,	PUNCT
dpc-5918	117	8	p53	p53	NOUN
dpc-5918	117	9	(	(	PUNCT
dpc-5918	117	10	biolegend	biolegend	NOUN
dpc-5918	117	11	,	,	PUNCT
dpc-5918	117	12	cat	cat	NOUN
dpc-5918	117	13	.	.	PUNCT
dpc-5918	118	1	no	no	PRON
dpc-5918	118	2	:	:	PUNCT
dpc-5918	118	3	645702	645702	NUM
dpc-5918	118	4	)	)	PUNCT
dpc-5918	118	5	,	,	PUNCT
dpc-5918	118	6	p21	p21	NOUN
dpc-5918	118	7	(	(	PUNCT
dpc-5918	118	8	bt	bt	NOUN
dpc-5918	118	9	lab	lab	PROPN
dpc-5918	118	10	,	,	PUNCT
dpc-5918	118	11	cat	cat	NOUN
dpc-5918	118	12	.	.	PUNCT
dpc-5918	119	1	no	no	PRON
dpc-5918	119	2	:	:	PUNCT
dpc-5918	120	1	bt	bt	ADJ
dpc-5918	120	2	-	-	NOUN
dpc-5918	120	3	ap12602	ap12602	NOUN
dpc-5918	120	4	)	)	PUNCT
dpc-5918	120	5	,	,	PUNCT
dpc-5918	120	6	mdm2	mdm2	PROPN
dpc-5918	120	7	(	(	PUNCT
dpc-5918	120	8	biogend	biogend	PROPN
dpc-5918	120	9	,	,	PUNCT
dpc-5918	120	10	cat	cat	NOUN
dpc-5918	120	11	.	.	PUNCT
dpc-5918	121	1	no	no	INTJ
dpc-5918	121	2	:	:	PUNCT
dpc-5918	121	3	e	e	X
dpc-5918	121	4	-	-	NOUN
dpc-5918	121	5	ab-60076	ab-60076	ADJ
dpc-5918	121	6	)	)	PUNCT
dpc-5918	121	7	,	,	PUNCT
dpc-5918	121	8	nf	nf	ADJ
dpc-5918	121	9	-	-	PUNCT
dpc-5918	121	10	κb	κb	ADJ
dpc-5918	121	11	p65	p65	NOUN
dpc-5918	121	12	(	(	PUNCT
dpc-5918	121	13	st	st	PROPN
dpc-5918	121	14	john	john	PROPN
dpc-5918	121	15	's	's	PART
dpc-5918	121	16	laboratory	laboratory	NOUN
dpc-5918	121	17	,	,	PUNCT
dpc-5918	121	18	cat	cat	NOUN
dpc-5918	121	19	.	.	PUNCT
dpc-5918	122	1	no	no	DET
dpc-5918	122	2	:	:	PUNCT
dpc-5918	122	3	stj903553	stj903553	NOUN
dpc-5918	122	4	-	-	PUNCT
dpc-5918	122	5	100	100	NUM
dpc-5918	122	6	)	)	PUNCT
dpc-5918	122	7	,	,	PUNCT
dpc-5918	122	8	4	4	NUM
dpc-5918	122	9	original	original	ADJ
dpc-5918	122	10	article	article	NOUN
dpc-5918	122	11	|	|	ADV
dpc-5918	122	12	dermatol	dermatol	ADJ
dpc-5918	122	13	pract	pract	NOUN
dpc-5918	122	14	concept	concept	NOUN
dpc-5918	122	15	.	.	PUNCT
dpc-5918	123	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	123	2	conducted	conduct	VERB
dpc-5918	123	3	using	use	VERB
dpc-5918	123	4	graphpad	graphpad	NOUN
dpc-5918	123	5	prism	prism	NOUN
dpc-5918	123	6	v9.0	v9.0	PROPN
dpc-5918	123	7	(	(	PUNCT
dpc-5918	123	8	graphpad	graphpad	NOUN
dpc-5918	123	9	software	software	NOUN
dpc-5918	123	10	,	,	PUNCT
dpc-5918	123	11	san	san	PROPN
dpc-5918	123	12	diego	diego	PROPN
dpc-5918	123	13	,	,	PUNCT
dpc-5918	123	14	ca	ca	PROPN
dpc-5918	123	15	,	,	PUNCT
dpc-5918	123	16	usa	usa	PROPN
dpc-5918	123	17	)	)	PUNCT
dpc-5918	123	18	.	.	PUNCT
dpc-5918	124	1	clinical	clinical	ADJ
dpc-5918	124	2	analysis	analysis	NOUN
dpc-5918	124	3	correlations	correlation	NOUN
dpc-5918	124	4	between	between	ADP
dpc-5918	124	5	grwd1	grwd1	NOUN
dpc-5918	124	6	expression	expression	NOUN
dpc-5918	124	7	and	and	CCONJ
dpc-5918	124	8	clinical	clinical	ADJ
dpc-5918	124	9	parameters	parameter	NOUN
dpc-5918	124	10	were	be	AUX
dpc-5918	124	11	analyzed	analyze	VERB
dpc-5918	124	12	.	.	PUNCT
dpc-5918	125	1	qualitative	qualitative	ADJ
dpc-5918	125	2	data	datum	NOUN
dpc-5918	125	3	are	be	AUX
dpc-5918	125	4	summarized	summarize	VERB
dpc-5918	125	5	as	as	ADP
dpc-5918	125	6	counts	count	NOUN
dpc-5918	125	7	and	and	CCONJ
dpc-5918	125	8	percentages	percentage	NOUN
dpc-5918	125	9	,	,	PUNCT
dpc-5918	125	10	while	while	SCONJ
dpc-5918	125	11	quantitative	quantitative	ADJ
dpc-5918	125	12	data	datum	NOUN
dpc-5918	125	13	are	be	AUX
dpc-5918	125	14	presented	present	VERB
dpc-5918	125	15	as	as	ADP
dpc-5918	125	16	minimum	minimum	ADJ
dpc-5918	125	17	and	and	CCONJ
dpc-5918	125	18	maximum	maximum	ADJ
dpc-5918	125	19	values	value	NOUN
dpc-5918	125	20	along	along	ADP
dpc-5918	125	21	with	with	ADP
dpc-5918	125	22	mean	mean	PROPN
dpc-5918	125	23	±	±	NUM
dpc-5918	125	24	standard	standard	ADJ
dpc-5918	125	25	deviation	deviation	NOUN
dpc-5918	125	26	(	(	PUNCT
dpc-5918	125	27	sd	sd	NOUN
dpc-5918	125	28	)	)	PUNCT
dpc-5918	125	29	.	.	PUNCT
dpc-5918	126	1	for	for	ADP
dpc-5918	126	2	the	the	DET
dpc-5918	126	3	comparison	comparison	NOUN
dpc-5918	126	4	of	of	ADP
dpc-5918	126	5	categorical	categorical	ADJ
dpc-5918	126	6	variables	variable	NOUN
dpc-5918	126	7	,	,	PUNCT
dpc-5918	126	8	pearson	pearson	PROPN
dpc-5918	126	9	’s	’s	PART
dpc-5918	126	10	chi	chi	ADJ
dpc-5918	126	11	-	-	PUNCT
dpc-5918	126	12	square	square	NOUN
dpc-5918	126	13	test	test	NOUN
dpc-5918	126	14	and	and	CCONJ
dpc-5918	126	15	yates	yates	PROPN
dpc-5918	126	16	'	'	PART
dpc-5918	126	17	corrected	correct	VERB
dpc-5918	126	18	chi	chi	ADJ
dpc-5918	126	19	-	-	PUNCT
dpc-5918	126	20	square	square	ADJ
dpc-5918	126	21	test	test	NOUN
dpc-5918	126	22	were	be	AUX
dpc-5918	126	23	used	use	VERB
dpc-5918	126	24	.	.	PUNCT
dpc-5918	127	1	since	since	SCONJ
dpc-5918	127	2	the	the	DET
dpc-5918	127	3	data	datum	NOUN
dpc-5918	127	4	did	do	AUX
dpc-5918	127	5	not	not	PART
dpc-5918	127	6	follow	follow	VERB
dpc-5918	127	7	a	a	DET
dpc-5918	127	8	normal	normal	ADJ
dpc-5918	127	9	distribution	distribution	NOUN
dpc-5918	127	10	,	,	PUNCT
dpc-5918	127	11	spearman	spearman	NOUN
dpc-5918	127	12	’s	’s	PART
dpc-5918	127	13	correlation	correlation	NOUN
dpc-5918	127	14	test	test	NOUN
dpc-5918	127	15	was	be	AUX
dpc-5918	127	16	applied	apply	VERB
dpc-5918	127	17	for	for	ADP
dpc-5918	127	18	correlation	correlation	NOUN
dpc-5918	127	19	analysis	analysis	NOUN
dpc-5918	127	20	.	.	PUNCT
dpc-5918	128	1	a	a	DET
dpc-5918	128	2	p	p	NOUN
dpc-5918	128	3	-	-	PUNCT
dpc-5918	128	4	value	value	NOUN
dpc-5918	128	5	<	<	NOUN
dpc-5918	128	6	0.05	0.05	NUM
dpc-5918	128	7	was	be	AUX
dpc-5918	128	8	considered	consider	VERB
dpc-5918	128	9	statistically	statistically	ADV
dpc-5918	128	10	significant	significant	ADJ
dpc-5918	128	11	.	.	PUNCT
dpc-5918	129	1	nonparametric	nonparametric	NOUN
dpc-5918	129	2	tests	test	NOUN
dpc-5918	129	3	(	(	PUNCT
dpc-5918	129	4	mann	mann	PROPN
dpc-5918	129	5	whitney	whitney	PROPN
dpc-5918	129	6	-	-	PUNCT
dpc-5918	129	7	u	u	PROPN
dpc-5918	129	8	test	test	NOUN
dpc-5918	129	9	)	)	PUNCT
dpc-5918	129	10	were	be	AUX
dpc-5918	129	11	used	use	VERB
dpc-5918	129	12	to	to	PART
dpc-5918	129	13	compare	compare	VERB
dpc-5918	129	14	breslow	breslow	NOUN
dpc-5918	129	15	score	score	NOUN
dpc-5918	129	16	,	,	PUNCT
dpc-5918	129	17	mitotic	mitotic	ADJ
dpc-5918	129	18	rate	rate	NOUN
dpc-5918	129	19	,	,	PUNCT
dpc-5918	129	20	and	and	CCONJ
dpc-5918	129	21	lesion	lesion	NOUN
dpc-5918	129	22	size	size	NOUN
dpc-5918	129	23	between	between	ADP
dpc-5918	129	24	different	different	ADJ
dpc-5918	129	25	groups	group	NOUN
dpc-5918	129	26	.	.	PUNCT
dpc-5918	130	1	experiments	experiment	NOUN
dpc-5918	130	2	were	be	AUX
dpc-5918	130	3	performed	perform	VERB
dpc-5918	130	4	in	in	ADP
dpc-5918	130	5	triplicate	triplicate	NOUN
dpc-5918	130	6	(	(	PUNCT
dpc-5918	130	7	n=3	n=3	NOUN
dpc-5918	130	8	)	)	PUNCT
dpc-5918	130	9	unless	unless	SCONJ
dpc-5918	130	10	otherwise	otherwise	ADV
dpc-5918	130	11	specified	specify	VERB
dpc-5918	130	12	.	.	PUNCT
dpc-5918	131	1	this	this	DET
dpc-5918	131	2	study	study	NOUN
dpc-5918	131	3	was	be	AUX
dpc-5918	131	4	approved	approve	VERB
dpc-5918	131	5	by	by	ADP
dpc-5918	131	6	clinical	clinical	ADJ
dpc-5918	131	7	research	research	NOUN
dpc-5918	131	8	ethics	ethic	NOUN
dpc-5918	131	9	committee	committee	PROPN
dpc-5918	131	10	of	of	ADP
dpc-5918	131	11	inonu	inonu	PROPN
dpc-5918	131	12	university	university	PROPN
dpc-5918	131	13	medical	medical	ADJ
dpc-5918	131	14	faculty	faculty	NOUN
dpc-5918	131	15	(	(	PUNCT
dpc-5918	131	16	2022/121	2022/121	NUM
dpc-5918	131	17	)	)	PUNCT
dpc-5918	131	18	.	.	PUNCT
dpc-5918	132	1	the	the	DET
dpc-5918	132	2	study	study	NOUN
dpc-5918	132	3	was	be	AUX
dpc-5918	132	4	supported	support	VERB
dpc-5918	132	5	by	by	ADP
dpc-5918	132	6	the	the	DET
dpc-5918	132	7	scientific	scientific	ADJ
dpc-5918	132	8	research	research	NOUN
dpc-5918	132	9	projects	project	NOUN
dpc-5918	132	10	coordination	coordination	NOUN
dpc-5918	132	11	unit	unit	NOUN
dpc-5918	132	12	of	of	ADP
dpc-5918	132	13	inonu	inonu	ADJ
dpc-5918	132	14	university	university	NOUN
dpc-5918	132	15	with	with	ADP
dpc-5918	132	16	the	the	DET
dpc-5918	132	17	project	project	NOUN
dpc-5918	132	18	code	code	NOUN
dpc-5918	132	19	tcd-2019	tcd-2019	NOUN
dpc-5918	132	20	-	-	PUNCT
dpc-5918	132	21	2018	2018	NUM
dpc-5918	132	22	.	.	PUNCT
dpc-5918	133	1	results	result	VERB
dpc-5918	133	2	high	high	ADJ
dpc-5918	133	3	grwd1	grwd1	NOUN
dpc-5918	133	4	expression	expression	NOUN
dpc-5918	133	5	is	be	AUX
dpc-5918	133	6	associated	associate	VERB
dpc-5918	133	7	with	with	ADP
dpc-5918	133	8	reduced	reduced	ADJ
dpc-5918	133	9	survival	survival	NOUN
dpc-5918	133	10	time	time	NOUN
dpc-5918	133	11	although	although	SCONJ
dpc-5918	133	12	the	the	DET
dpc-5918	133	13	relationship	relationship	NOUN
dpc-5918	133	14	between	between	ADP
dpc-5918	133	15	grwd1	grwd1	NOUN
dpc-5918	133	16	expression	expression	NOUN
dpc-5918	133	17	and	and	CCONJ
dpc-5918	133	18	survival	survival	NOUN
dpc-5918	133	19	is	be	AUX
dpc-5918	133	20	reported	report	VERB
dpc-5918	133	21	to	to	PART
dpc-5918	133	22	be	be	AUX
dpc-5918	133	23	complex	complex	ADJ
dpc-5918	133	24	and	and	CCONJ
dpc-5918	133	25	cancer	cancer	NOUN
dpc-5918	133	26	-	-	PUNCT
dpc-5918	133	27	type	type	NOUN
dpc-5918	133	28	specific	specific	ADJ
dpc-5918	133	29	,	,	PUNCT
dpc-5918	133	30	in	in	ADP
dpc-5918	133	31	general	general	ADJ
dpc-5918	133	32	,	,	PUNCT
dpc-5918	133	33	high	high	ADJ
dpc-5918	133	34	grwd1	grwd1	NOUN
dpc-5918	133	35	expression	expression	NOUN
dpc-5918	133	36	has	have	AUX
dpc-5918	133	37	been	be	AUX
dpc-5918	133	38	linked	link	VERB
dpc-5918	133	39	to	to	ADP
dpc-5918	133	40	poor	poor	ADJ
dpc-5918	133	41	prognosis	prognosis	NOUN
dpc-5918	133	42	and	and	CCONJ
dpc-5918	133	43	decreased	decrease	VERB
dpc-5918	133	44	survival	survival	NOUN
dpc-5918	133	45	time	time	NOUN
dpc-5918	133	46	in	in	ADP
dpc-5918	133	47	various	various	ADJ
dpc-5918	133	48	cancer	cancer	NOUN
dpc-5918	133	49	types	type	NOUN
dpc-5918	133	50	[	[	X
dpc-5918	133	51	13	13	NUM
dpc-5918	133	52	]	]	PUNCT
dpc-5918	133	53	.	.	PUNCT
dpc-5918	134	1	to	to	PART
dpc-5918	134	2	determine	determine	VERB
dpc-5918	134	3	the	the	DET
dpc-5918	134	4	relationship	relationship	NOUN
dpc-5918	134	5	between	between	ADP
dpc-5918	134	6	grwd1	grwd1	NOUN
dpc-5918	134	7	expression	expression	NOUN
dpc-5918	134	8	and	and	CCONJ
dpc-5918	134	9	patient	patient	ADJ
dpc-5918	134	10	survival	survival	NOUN
dpc-5918	134	11	in	in	ADP
dpc-5918	134	12	melanoma	melanoma	NOUN
dpc-5918	134	13	cases	case	NOUN
dpc-5918	134	14	,	,	PUNCT
dpc-5918	134	15	data	datum	NOUN
dpc-5918	134	16	from	from	ADP
dpc-5918	134	17	the	the	DET
dpc-5918	134	18	cancer	cancer	NOUN
dpc-5918	134	19	genome	genome	NOUN
dpc-5918	134	20	atlas	atlas	PROPN
dpc-5918	134	21	(	(	PUNCT
dpc-5918	134	22	tcga	tcga	PROPN
dpc-5918	134	23	)	)	PUNCT
dpc-5918	134	24	database	database	NOUN
dpc-5918	134	25	were	be	AUX
dpc-5918	134	26	analyzed	analyze	VERB
dpc-5918	134	27	.	.	PUNCT
dpc-5918	135	1	however	however	ADV
dpc-5918	135	2	,	,	PUNCT
dpc-5918	135	3	tcga	tcga	PROPN
dpc-5918	135	4	data	datum	NOUN
dpc-5918	135	5	did	do	AUX
dpc-5918	135	6	not	not	PART
dpc-5918	135	7	provide	provide	VERB
dpc-5918	135	8	datasets	dataset	NOUN
dpc-5918	135	9	that	that	PRON
dpc-5918	135	10	allowed	allow	VERB
dpc-5918	135	11	a	a	DET
dpc-5918	135	12	direct	direct	ADJ
dpc-5918	135	13	comparison	comparison	NOUN
dpc-5918	135	14	of	of	ADP
dpc-5918	135	15	grwd1	grwd1	NOUN
dpc-5918	135	16	expression	expression	NOUN
dpc-5918	135	17	between	between	ADP
dpc-5918	135	18	normal	normal	ADJ
dpc-5918	135	19	skin	skin	NOUN
dpc-5918	135	20	and	and	CCONJ
dpc-5918	135	21	melanoma	melanoma	NOUN
dpc-5918	135	22	tumor	tumor	NOUN
dpc-5918	135	23	tissues	tissue	NOUN
dpc-5918	135	24	.	.	PUNCT
dpc-5918	136	1	additionally	additionally	ADV
dpc-5918	136	2	,	,	PUNCT
dpc-5918	136	3	no	no	DET
dpc-5918	136	4	significant	significant	ADJ
dpc-5918	136	5	difference	difference	NOUN
dpc-5918	136	6	in	in	ADP
dpc-5918	136	7	grwd1	grwd1	NOUN
dpc-5918	136	8	expression	expression	NOUN
dpc-5918	136	9	was	be	AUX
dpc-5918	136	10	observed	observe	VERB
dpc-5918	136	11	between	between	ADP
dpc-5918	136	12	primary	primary	ADJ
dpc-5918	136	13	and	and	CCONJ
dpc-5918	136	14	metastatic	metastatic	ADJ
dpc-5918	136	15	tumors	tumor	NOUN
dpc-5918	136	16	(	(	PUNCT
dpc-5918	136	17	figure	figure	VERB
dpc-5918	136	18	1a	1a	NOUN
dpc-5918	136	19	)	)	PUNCT
dpc-5918	136	20	.	.	PUNCT
dpc-5918	137	1	nevertheless	nevertheless	ADV
dpc-5918	137	2	,	,	PUNCT
dpc-5918	137	3	survival	survival	NOUN
dpc-5918	137	4	analysis	analysis	NOUN
dpc-5918	137	5	revealed	reveal	VERB
dpc-5918	137	6	that	that	SCONJ
dpc-5918	137	7	high	high	ADJ
dpc-5918	137	8	grwd1	grwd1	NOUN
dpc-5918	137	9	expression	expression	NOUN
dpc-5918	137	10	in	in	ADP
dpc-5918	137	11	melanoma	melanoma	NOUN
dpc-5918	137	12	was	be	AUX
dpc-5918	137	13	significantly	significantly	ADV
dpc-5918	137	14	associated	associate	VERB
dpc-5918	137	15	with	with	ADP
dpc-5918	137	16	reduced	reduced	ADJ
dpc-5918	137	17	patient	patient	ADJ
dpc-5918	137	18	survival	survival	NOUN
dpc-5918	137	19	(	(	PUNCT
dpc-5918	137	20	figure	figure	NOUN
dpc-5918	137	21	1b	1b	NUM
dpc-5918	137	22	)	)	PUNCT
dpc-5918	137	23	.	.	PUNCT
dpc-5918	138	1	when	when	SCONJ
dpc-5918	138	2	examining	examine	VERB
dpc-5918	138	3	primary	primary	ADJ
dpc-5918	138	4	and	and	CCONJ
dpc-5918	138	5	metastatic	metastatic	ADJ
dpc-5918	138	6	tumors	tumor	NOUN
dpc-5918	138	7	separately	separately	ADV
dpc-5918	138	8	,	,	PUNCT
dpc-5918	138	9	high	high	ADJ
dpc-5918	138	10	grwd1	grwd1	NOUN
dpc-5918	138	11	expression	expression	NOUN
dpc-5918	138	12	in	in	ADP
dpc-5918	138	13	primary	primary	ADJ
dpc-5918	138	14	tumors	tumor	NOUN
dpc-5918	138	15	was	be	AUX
dpc-5918	138	16	associated	associate	VERB
dpc-5918	138	17	with	with	ADP
dpc-5918	138	18	decreased	decrease	VERB
dpc-5918	138	19	survival	survival	NOUN
dpc-5918	138	20	,	,	PUNCT
dpc-5918	138	21	although	although	SCONJ
dpc-5918	138	22	this	this	DET
dpc-5918	138	23	finding	finding	NOUN
dpc-5918	138	24	was	be	AUX
dpc-5918	138	25	not	not	PART
dpc-5918	138	26	statistically	statistically	ADV
dpc-5918	138	27	significant	significant	ADJ
dpc-5918	138	28	(	(	PUNCT
dpc-5918	138	29	figure	figure	NOUN
dpc-5918	138	30	1c	1c	NOUN
dpc-5918	138	31	)	)	PUNCT
dpc-5918	138	32	.	.	PUNCT
dpc-5918	139	1	in	in	ADP
dpc-5918	139	2	contrast	contrast	NOUN
dpc-5918	139	3	,	,	PUNCT
dpc-5918	139	4	in	in	ADP
dpc-5918	139	5	metastatic	metastatic	ADJ
dpc-5918	139	6	tumors	tumor	NOUN
dpc-5918	139	7	,	,	PUNCT
dpc-5918	139	8	high	high	ADJ
dpc-5918	139	9	grwd1	grwd1	NOUN
dpc-5918	139	10	expression	expression	NOUN
dpc-5918	139	11	was	be	AUX
dpc-5918	139	12	significantly	significantly	ADV
dpc-5918	139	13	correlated	correlate	VERB
dpc-5918	139	14	with	with	ADP
dpc-5918	139	15	markedly	markedly	ADV
dpc-5918	139	16	reduced	reduce	VERB
dpc-5918	139	17	survival	survival	NOUN
dpc-5918	139	18	(	(	PUNCT
dpc-5918	139	19	figure	figure	NOUN
dpc-5918	139	20	1d	1d	NUM
dpc-5918	139	21	)	)	PUNCT
dpc-5918	139	22	.	.	PUNCT
dpc-5918	140	1	these	these	DET
dpc-5918	140	2	findings	finding	NOUN
dpc-5918	140	3	suggest	suggest	VERB
dpc-5918	140	4	that	that	SCONJ
dpc-5918	140	5	grwd1	grwd1	NOUN
dpc-5918	140	6	expression	expression	NOUN
dpc-5918	140	7	is	be	AUX
dpc-5918	140	8	associated	associate	VERB
dpc-5918	140	9	with	with	ADP
dpc-5918	140	10	aggressive	aggressive	ADJ
dpc-5918	140	11	tumor	tumor	NOUN
dpc-5918	140	12	characteristics	characteristic	NOUN
dpc-5918	140	13	and	and	CCONJ
dpc-5918	140	14	poor	poor	ADJ
dpc-5918	140	15	prognosis	prognosis	NOUN
dpc-5918	140	16	in	in	ADP
dpc-5918	140	17	melanoma	melanoma	NOUN
dpc-5918	140	18	.	.	PUNCT
dpc-5918	141	1	src	src	NOUN
dpc-5918	141	2	(	(	PUNCT
dpc-5918	141	3	cell	cell	NOUN
dpc-5918	141	4	signaling	signaling	NOUN
dpc-5918	141	5	,	,	PUNCT
dpc-5918	141	6	cat	cat	NOUN
dpc-5918	141	7	.	.	PUNCT
dpc-5918	142	1	no	no	PRON
dpc-5918	142	2	:	:	PUNCT
dpc-5918	142	3	2108s	2108s	NUM
dpc-5918	142	4	)	)	PUNCT
dpc-5918	142	5	,	,	PUNCT
dpc-5918	142	6	and	and	CCONJ
dpc-5918	142	7	β	β	X
dpc-5918	142	8	-	-	NOUN
dpc-5918	142	9	actin	actin	NOUN
dpc-5918	142	10	(	(	PUNCT
dpc-5918	142	11	santa	santa	PROPN
dpc-5918	142	12	cruz	cruz	PROPN
dpc-5918	142	13	,	,	PUNCT
dpc-5918	142	14	cat	cat	NOUN
dpc-5918	142	15	.	.	PUNCT
dpc-5918	143	1	no	no	DET
dpc-5918	143	2	:	:	PUNCT
dpc-5918	143	3	sc-47778	sc-47778	PROPN
dpc-5918	143	4	)	)	PUNCT
dpc-5918	143	5	as	as	ADP
dpc-5918	143	6	a	a	DET
dpc-5918	143	7	loading	loading	NOUN
dpc-5918	143	8	control	control	NOUN
dpc-5918	143	9	.	.	PUNCT
dpc-5918	144	1	after	after	ADP
dpc-5918	144	2	washing	washing	NOUN
dpc-5918	144	3	,	,	PUNCT
dpc-5918	144	4	membranes	membrane	NOUN
dpc-5918	144	5	were	be	AUX
dpc-5918	144	6	incubated	incubate	VERB
dpc-5918	144	7	with	with	ADP
dpc-5918	144	8	hrp	hrp	PROPN
dpc-5918	144	9	-	-	PUNCT
dpc-5918	144	10	conjugated	conjugate	VERB
dpc-5918	144	11	secondary	secondary	ADJ
dpc-5918	144	12	antibodies	antibody	NOUN
dpc-5918	144	13	,	,	PUNCT
dpc-5918	144	14	including	include	VERB
dpc-5918	144	15	goat	goat	PROPN
dpc-5918	144	16	anti	anti	ADJ
dpc-5918	144	17	-	-	ADJ
dpc-5918	144	18	rabbit	rabbit	ADJ
dpc-5918	144	19	hrp	hrp	NOUN
dpc-5918	144	20	(	(	PUNCT
dpc-5918	144	21	cell	cell	NOUN
dpc-5918	144	22	signaling	signal	VERB
dpc-5918	144	23	technology	technology	NOUN
dpc-5918	144	24	,	,	PUNCT
dpc-5918	144	25	cat	cat	NOUN
dpc-5918	144	26	.	.	PUNCT
dpc-5918	145	1	no	no	PRON
dpc-5918	145	2	:	:	PUNCT
dpc-5918	145	3	7074s	7074s	NUM
dpc-5918	145	4	)	)	PUNCT
dpc-5918	146	1	and	and	CCONJ
dpc-5918	146	2	goat	goat	PROPN
dpc-5918	146	3	anti	anti	ADJ
dpc-5918	146	4	-	-	ADJ
dpc-5918	146	5	mouse	mouse	ADJ
dpc-5918	146	6	hrp	hrp	NOUN
dpc-5918	146	7	(	(	PUNCT
dpc-5918	146	8	cell	cell	NOUN
dpc-5918	146	9	signaling	signal	VERB
dpc-5918	146	10	technology	technology	NOUN
dpc-5918	146	11	,	,	PUNCT
dpc-5918	146	12	cat	cat	NOUN
dpc-5918	146	13	.	.	PUNCT
dpc-5918	147	1	no	no	PRON
dpc-5918	147	2	:	:	PUNCT
dpc-5918	147	3	7076s	7076s	NUM
dpc-5918	147	4	)	)	PUNCT
dpc-5918	147	5	.	.	PUNCT
dpc-5918	148	1	protein	protein	NOUN
dpc-5918	148	2	bands	band	NOUN
dpc-5918	148	3	were	be	AUX
dpc-5918	148	4	detected	detect	VERB
dpc-5918	148	5	using	use	VERB
dpc-5918	148	6	the	the	DET
dpc-5918	148	7	chemidoc	chemidoc	ADJ
dpc-5918	148	8	imaging	imaging	NOUN
dpc-5918	148	9	system	system	NOUN
dpc-5918	148	10	,	,	PUNCT
dpc-5918	148	11	and	and	CCONJ
dpc-5918	148	12	densitometric	densitometric	ADJ
dpc-5918	148	13	analysis	analysis	NOUN
dpc-5918	148	14	was	be	AUX
dpc-5918	148	15	conducted	conduct	VERB
dpc-5918	148	16	using	use	VERB
dpc-5918	148	17	imagej	imagej	ADJ
dpc-5918	148	18	software	software	NOUN
dpc-5918	148	19	.	.	PUNCT
dpc-5918	149	1	histopathological	histopathological	ADJ
dpc-5918	149	2	examination	examination	NOUN
dpc-5918	149	3	the	the	DET
dpc-5918	149	4	slides	slide	NOUN
dpc-5918	149	5	and	and	CCONJ
dpc-5918	149	6	blocks	block	NOUN
dpc-5918	149	7	of	of	ADP
dpc-5918	149	8	the	the	DET
dpc-5918	149	9	patients	patient	NOUN
dpc-5918	149	10	included	include	VERB
dpc-5918	149	11	in	in	ADP
dpc-5918	149	12	the	the	DET
dpc-5918	149	13	histopathological	histopathological	ADJ
dpc-5918	149	14	study	study	NOUN
dpc-5918	149	15	were	be	AUX
dpc-5918	149	16	evaluated	evaluate	VERB
dpc-5918	149	17	.	.	PUNCT
dpc-5918	150	1	appropriate	appropriate	ADJ
dpc-5918	150	2	samples	sample	NOUN
dpc-5918	150	3	were	be	AUX
dpc-5918	150	4	selected	select	VERB
dpc-5918	150	5	,	,	PUNCT
dpc-5918	150	6	and	and	CCONJ
dpc-5918	150	7	tissues	tissue	NOUN
dpc-5918	150	8	were	be	AUX
dpc-5918	150	9	re	re	VERB
dpc-5918	150	10	-	-	VERB
dpc-5918	150	11	blocked	block	VERB
dpc-5918	150	12	after	after	ADP
dpc-5918	150	13	being	be	AUX
dpc-5918	150	14	taken	take	VERB
dpc-5918	150	15	from	from	ADP
dpc-5918	150	16	the	the	DET
dpc-5918	150	17	blocks	block	NOUN
dpc-5918	150	18	using	use	VERB
dpc-5918	150	19	the	the	DET
dpc-5918	150	20	microarray	microarray	NOUN
dpc-5918	150	21	method	method	NOUN
dpc-5918	150	22	.	.	PUNCT
dpc-5918	151	1	routine	routine	ADJ
dpc-5918	151	2	h&e	h&e	PROPN
dpc-5918	151	3	staining	stain	VERB
dpc-5918	151	4	and	and	CCONJ
dpc-5918	151	5	immunohistochemical	immunohistochemical	ADJ
dpc-5918	151	6	staining	staining	NOUN
dpc-5918	151	7	with	with	ADP
dpc-5918	151	8	the	the	DET
dpc-5918	151	9	grwd1	grwd1	NOUN
dpc-5918	151	10	antibody	antibody	NOUN
dpc-5918	151	11	were	be	AUX
dpc-5918	151	12	applied	apply	VERB
dpc-5918	151	13	to	to	ADP
dpc-5918	151	14	the	the	DET
dpc-5918	151	15	sections	section	NOUN
dpc-5918	151	16	obtained	obtain	VERB
dpc-5918	151	17	from	from	ADP
dpc-5918	151	18	the	the	DET
dpc-5918	151	19	new	new	ADJ
dpc-5918	151	20	blocks	block	NOUN
dpc-5918	151	21	.	.	PUNCT
dpc-5918	152	1	based	base	VERB
dpc-5918	152	2	on	on	ADP
dpc-5918	152	3	grwd1	grwd1	ADJ
dpc-5918	152	4	staining	stain	VERB
dpc-5918	152	5	intensity	intensity	NOUN
dpc-5918	152	6	,	,	PUNCT
dpc-5918	152	7	nuclear	nuclear	ADJ
dpc-5918	152	8	and	and	CCONJ
dpc-5918	152	9	cytoplasmic	cytoplasmic	ADJ
dpc-5918	152	10	staining	stain	VERB
dpc-5918	152	11	intensity	intensity	NOUN
dpc-5918	152	12	was	be	AUX
dpc-5918	152	13	graded	grade	VERB
dpc-5918	152	14	as	as	ADP
dpc-5918	152	15	strong	strong	ADJ
dpc-5918	152	16	(	(	PUNCT
dpc-5918	152	17	+3	+3	PROPN
dpc-5918	152	18	)	)	PUNCT
dpc-5918	152	19	,	,	PUNCT
dpc-5918	152	20	moderate	moderate	ADJ
dpc-5918	152	21	(	(	PUNCT
dpc-5918	152	22	+2	+2	PROPN
dpc-5918	152	23	)	)	PUNCT
dpc-5918	152	24	,	,	PUNCT
dpc-5918	152	25	weak	weak	ADJ
dpc-5918	152	26	(	(	PUNCT
dpc-5918	152	27	+1	+1	NOUN
dpc-5918	152	28	)	)	PUNCT
dpc-5918	152	29	,	,	PUNCT
dpc-5918	152	30	or	or	CCONJ
dpc-5918	152	31	negative	negative	ADJ
dpc-5918	152	32	(	(	PUNCT
dpc-5918	152	33	0	0	NUM
dpc-5918	152	34	)	)	PUNCT
dpc-5918	152	35	.	.	PUNCT
dpc-5918	153	1	the	the	DET
dpc-5918	153	2	medical	medical	ADJ
dpc-5918	153	3	records	record	NOUN
dpc-5918	153	4	of	of	ADP
dpc-5918	153	5	the	the	DET
dpc-5918	153	6	patients	patient	NOUN
dpc-5918	153	7	included	include	VERB
dpc-5918	153	8	in	in	ADP
dpc-5918	153	9	the	the	DET
dpc-5918	153	10	study	study	NOUN
dpc-5918	153	11	were	be	AUX
dpc-5918	153	12	thoroughly	thoroughly	ADV
dpc-5918	153	13	reviewed	review	VERB
dpc-5918	153	14	.	.	PUNCT
dpc-5918	154	1	demographic	demographic	ADJ
dpc-5918	154	2	,	,	PUNCT
dpc-5918	154	3	clinical	clinical	ADJ
dpc-5918	154	4	,	,	PUNCT
dpc-5918	154	5	and	and	CCONJ
dpc-5918	154	6	biopsy	biopsy	NOUN
dpc-5918	154	7	data	datum	NOUN
dpc-5918	154	8	such	such	ADJ
dpc-5918	154	9	as	as	ADP
dpc-5918	154	10	age	age	NOUN
dpc-5918	154	11	,	,	PUNCT
dpc-5918	154	12	sex	sex	NOUN
dpc-5918	154	13	,	,	PUNCT
dpc-5918	154	14	melanoma	melanoma	NOUN
dpc-5918	154	15	type	type	NOUN
dpc-5918	154	16	,	,	PUNCT
dpc-5918	154	17	breslow	breslow	NOUN
dpc-5918	154	18	score	score	NOUN
dpc-5918	154	19	,	,	PUNCT
dpc-5918	154	20	lesion	lesion	NOUN
dpc-5918	154	21	size	size	NOUN
dpc-5918	154	22	,	,	PUNCT
dpc-5918	154	23	ulceration	ulceration	NOUN
dpc-5918	154	24	,	,	PUNCT
dpc-5918	154	25	localization	localization	NOUN
dpc-5918	154	26	,	,	PUNCT
dpc-5918	154	27	mitotic	mitotic	ADJ
dpc-5918	154	28	rate	rate	NOUN
dpc-5918	154	29	,	,	PUNCT
dpc-5918	154	30	and	and	CCONJ
dpc-5918	154	31	metastasis	metastasis	NOUN
dpc-5918	154	32	were	be	AUX
dpc-5918	154	33	recorded	record	VERB
dpc-5918	154	34	.	.	PUNCT
dpc-5918	155	1	the	the	DET
dpc-5918	155	2	relationship	relationship	NOUN
dpc-5918	155	3	between	between	ADP
dpc-5918	155	4	staining	stain	VERB
dpc-5918	155	5	intensity	intensity	NOUN
dpc-5918	155	6	and	and	CCONJ
dpc-5918	155	7	sex	sex	NOUN
dpc-5918	155	8	,	,	PUNCT
dpc-5918	155	9	melanoma	melanoma	NOUN
dpc-5918	155	10	type	type	NOUN
dpc-5918	155	11	,	,	PUNCT
dpc-5918	155	12	breslow	breslow	NOUN
dpc-5918	155	13	score	score	NOUN
dpc-5918	155	14	,	,	PUNCT
dpc-5918	155	15	lesion	lesion	NOUN
dpc-5918	155	16	size	size	NOUN
dpc-5918	155	17	,	,	PUNCT
dpc-5918	155	18	ulceration	ulceration	NOUN
dpc-5918	155	19	,	,	PUNCT
dpc-5918	155	20	localization	localization	NOUN
dpc-5918	155	21	,	,	PUNCT
dpc-5918	155	22	and	and	CCONJ
dpc-5918	155	23	metastasis	metastasis	NOUN
dpc-5918	155	24	was	be	AUX
dpc-5918	155	25	investigated	investigate	VERB
dpc-5918	155	26	.	.	PUNCT
dpc-5918	156	1	numerical	numerical	ADJ
dpc-5918	156	2	data	datum	NOUN
dpc-5918	156	3	such	such	ADJ
dpc-5918	156	4	as	as	ADP
dpc-5918	156	5	breslow	breslow	NOUN
dpc-5918	156	6	score	score	NOUN
dpc-5918	156	7	,	,	PUNCT
dpc-5918	156	8	mitotic	mitotic	ADJ
dpc-5918	156	9	rate	rate	NOUN
dpc-5918	156	10	,	,	PUNCT
dpc-5918	156	11	lesion	lesion	NOUN
dpc-5918	156	12	size	size	NOUN
dpc-5918	156	13	,	,	PUNCT
dpc-5918	156	14	and	and	CCONJ
dpc-5918	156	15	survival	survival	NOUN
dpc-5918	156	16	were	be	AUX
dpc-5918	156	17	compared	compare	VERB
dpc-5918	156	18	among	among	ADP
dpc-5918	156	19	different	different	ADJ
dpc-5918	156	20	groups	group	NOUN
dpc-5918	156	21	.	.	PUNCT
dpc-5918	157	1	correlation	correlation	NOUN
dpc-5918	157	2	analysis	analysis	NOUN
dpc-5918	157	3	was	be	AUX
dpc-5918	157	4	performed	perform	VERB
dpc-5918	157	5	between	between	ADP
dpc-5918	157	6	age	age	NOUN
dpc-5918	157	7	,	,	PUNCT
dpc-5918	157	8	breslow	breslow	NOUN
dpc-5918	157	9	score	score	NOUN
dpc-5918	157	10	,	,	PUNCT
dpc-5918	157	11	mitotic	mitotic	ADJ
dpc-5918	157	12	rate	rate	NOUN
dpc-5918	157	13	,	,	PUNCT
dpc-5918	157	14	lesion	lesion	NOUN
dpc-5918	157	15	size	size	NOUN
dpc-5918	157	16	,	,	PUNCT
dpc-5918	157	17	survival	survival	NOUN
dpc-5918	157	18	,	,	PUNCT
dpc-5918	157	19	and	and	CCONJ
dpc-5918	157	20	staining	stain	VERB
dpc-5918	157	21	intensity	intensity	NOUN
dpc-5918	157	22	.	.	PUNCT
dpc-5918	158	1	statistical	statistical	ADJ
dpc-5918	158	2	analysis	analysis	NOUN
dpc-5918	158	3	in	in	ADP
dpc-5918	158	4	vitro	vitro	X
dpc-5918	158	5	analysis	analysis	NOUN
dpc-5918	158	6	for	for	ADP
dpc-5918	158	7	in	in	ADP
dpc-5918	158	8	vitro	vitro	X
dpc-5918	158	9	experiments	experiment	NOUN
dpc-5918	158	10	(	(	PUNCT
dpc-5918	158	11	including	include	VERB
dpc-5918	158	12	mts	mts	NOUN
dpc-5918	158	13	proliferation	proliferation	NOUN
dpc-5918	158	14	assay	assay	VERB
dpc-5918	158	15	,	,	PUNCT
dpc-5918	158	16	annexin	annexin	NOUN
dpc-5918	158	17	v	v	ADP
dpc-5918	158	18	/	/	SYM
dpc-5918	158	19	pi	pi	NOUN
dpc-5918	158	20	apoptosis	apoptosis	NOUN
dpc-5918	158	21	analysis	analysis	NOUN
dpc-5918	158	22	,	,	PUNCT
dpc-5918	158	23	caspase-3	caspase-3	NUM
dpc-5918	158	24	activation	activation	NOUN
dpc-5918	158	25	,	,	PUNCT
dpc-5918	158	26	cell	cell	NOUN
dpc-5918	158	27	cycle	cycle	NOUN
dpc-5918	158	28	distribution	distribution	NOUN
dpc-5918	158	29	,	,	PUNCT
dpc-5918	158	30	invasion	invasion	NOUN
dpc-5918	158	31	assay	assay	VERB
dpc-5918	158	32	,	,	PUNCT
dpc-5918	158	33	and	and	CCONJ
dpc-5918	158	34	western	western	ADJ
dpc-5918	158	35	blot	blot	NOUN
dpc-5918	158	36	quantifications	quantification	NOUN
dpc-5918	158	37	)	)	PUNCT
dpc-5918	158	38	,	,	PUNCT
dpc-5918	158	39	data	datum	NOUN
dpc-5918	158	40	were	be	AUX
dpc-5918	158	41	collected	collect	VERB
dpc-5918	158	42	from	from	ADP
dpc-5918	158	43	three	three	NUM
dpc-5918	158	44	independent	independent	ADJ
dpc-5918	158	45	biological	biological	ADJ
dpc-5918	158	46	replicates	replicate	NOUN
dpc-5918	158	47	(	(	PUNCT
dpc-5918	158	48	n=3	n=3	NOUN
dpc-5918	158	49	)	)	PUNCT
dpc-5918	158	50	,	,	PUNCT
dpc-5918	158	51	each	each	PRON
dpc-5918	158	52	performed	perform	VERB
dpc-5918	158	53	under	under	ADP
dpc-5918	158	54	identical	identical	ADJ
dpc-5918	158	55	conditions	condition	NOUN
dpc-5918	158	56	.	.	PUNCT
dpc-5918	159	1	results	result	NOUN
dpc-5918	159	2	are	be	AUX
dpc-5918	159	3	presented	present	VERB
dpc-5918	159	4	as	as	ADP
dpc-5918	159	5	mean	mean	NOUN
dpc-5918	159	6	±	±	NUM
dpc-5918	159	7	standard	standard	ADJ
dpc-5918	159	8	deviation	deviation	NOUN
dpc-5918	159	9	(	(	PUNCT
dpc-5918	159	10	sd	sd	NOUN
dpc-5918	159	11	)	)	PUNCT
dpc-5918	159	12	.	.	PUNCT
dpc-5918	160	1	comparisons	comparison	NOUN
dpc-5918	160	2	among	among	ADP
dpc-5918	160	3	the	the	DET
dpc-5918	160	4	three	three	NUM
dpc-5918	160	5	groups	group	NOUN
dpc-5918	160	6	(	(	PUNCT
dpc-5918	160	7	untreated	untreated	ADJ
dpc-5918	160	8	control	control	NOUN
dpc-5918	160	9	,	,	PUNCT
dpc-5918	160	10	non	non	ADJ
dpc-5918	160	11	-	-	ADJ
dpc-5918	160	12	targeting	targeting	ADJ
dpc-5918	160	13	sirna	sirna	NOUN
dpc-5918	160	14	,	,	PUNCT
dpc-5918	160	15	and	and	CCONJ
dpc-5918	160	16	grwd1	grwd1	PROPN
dpc-5918	160	17	sirna	sirna	PROPN
dpc-5918	160	18	)	)	PUNCT
dpc-5918	160	19	were	be	AUX
dpc-5918	160	20	performed	perform	VERB
dpc-5918	160	21	using	use	VERB
dpc-5918	160	22	one	one	NUM
dpc-5918	160	23	-	-	PUNCT
dpc-5918	160	24	way	way	NOUN
dpc-5918	160	25	analysis	analysis	NOUN
dpc-5918	160	26	of	of	ADP
dpc-5918	160	27	variance	variance	NOUN
dpc-5918	160	28	(	(	PUNCT
dpc-5918	160	29	anova	anova	PROPN
dpc-5918	160	30	)	)	PUNCT
dpc-5918	160	31	followed	follow	VERB
dpc-5918	160	32	by	by	ADP
dpc-5918	160	33	tukey	tukey	PROPN
dpc-5918	160	34	’s	’s	PART
dpc-5918	160	35	multiple	multiple	ADJ
dpc-5918	160	36	comparison	comparison	NOUN
dpc-5918	160	37	post	post	X
dpc-5918	160	38	hoc	hoc	X
dpc-5918	160	39	test	test	NOUN
dpc-5918	160	40	to	to	PART
dpc-5918	160	41	determine	determine	VERB
dpc-5918	160	42	statistical	statistical	ADJ
dpc-5918	160	43	significance	significance	NOUN
dpc-5918	160	44	between	between	ADP
dpc-5918	160	45	specific	specific	ADJ
dpc-5918	160	46	pairs	pair	NOUN
dpc-5918	160	47	of	of	ADP
dpc-5918	160	48	groups	group	NOUN
dpc-5918	160	49	.	.	PUNCT
dpc-5918	161	1	a	a	PRON
dpc-5918	161	2	p	p	NOUN
dpc-5918	161	3	-	-	PUNCT
dpc-5918	161	4	value	value	NOUN
dpc-5918	161	5	<	<	NOUN
dpc-5918	161	6	0.05	0.05	NUM
dpc-5918	161	7	was	be	AUX
dpc-5918	161	8	considered	consider	VERB
dpc-5918	161	9	statistically	statistically	ADV
dpc-5918	161	10	significant	significant	ADJ
dpc-5918	161	11	.	.	PUNCT
dpc-5918	162	1	student	student	NOUN
dpc-5918	162	2	's	's	PART
dpc-5918	162	3	t	t	PROPN
dpc-5918	162	4	-	-	PUNCT
dpc-5918	162	5	test	test	NOUN
dpc-5918	162	6	was	be	AUX
dpc-5918	162	7	used	use	VERB
dpc-5918	162	8	for	for	ADP
dpc-5918	162	9	colony	colony	NOUN
dpc-5918	162	10	formation	formation	NOUN
dpc-5918	162	11	ability	ability	NOUN
dpc-5918	162	12	.	.	PUNCT
dpc-5918	163	1	western	western	ADJ
dpc-5918	163	2	blot	blot	NOUN
dpc-5918	163	3	band	band	NOUN
dpc-5918	163	4	intensities	intensity	NOUN
dpc-5918	163	5	were	be	AUX
dpc-5918	163	6	quantified	quantify	VERB
dpc-5918	163	7	using	use	VERB
dpc-5918	163	8	imagej	imagej	ADJ
dpc-5918	163	9	software	software	NOUN
dpc-5918	163	10	and	and	CCONJ
dpc-5918	163	11	normalized	normalize	VERB
dpc-5918	163	12	to	to	ADP
dpc-5918	163	13	β	β	NOUN
dpc-5918	163	14	-	-	PUNCT
dpc-5918	163	15	actin	actin	VERB
dpc-5918	163	16	prior	prior	ADV
dpc-5918	163	17	to	to	ADP
dpc-5918	163	18	statistical	statistical	ADJ
dpc-5918	163	19	comparison	comparison	NOUN
dpc-5918	163	20	.	.	PUNCT
dpc-5918	164	1	flow	flow	NOUN
dpc-5918	164	2	cytometry	cytometry	PROPN
dpc-5918	164	3	data	datum	NOUN
dpc-5918	164	4	(	(	PUNCT
dpc-5918	164	5	annexin	annexin	NOUN
dpc-5918	164	6	v	v	NOUN
dpc-5918	164	7	,	,	PUNCT
dpc-5918	164	8	caspase-3	caspase-3	NUM
dpc-5918	164	9	,	,	PUNCT
dpc-5918	164	10	and	and	CCONJ
dpc-5918	164	11	cell	cell	NOUN
dpc-5918	164	12	cycle	cycle	NOUN
dpc-5918	164	13	analyses	analysis	NOUN
dpc-5918	164	14	)	)	PUNCT
dpc-5918	164	15	were	be	AUX
dpc-5918	164	16	collected	collect	VERB
dpc-5918	164	17	from	from	ADP
dpc-5918	164	18	at	at	ADP
dpc-5918	164	19	least	least	ADJ
dpc-5918	164	20	10,000	10,000	NUM
dpc-5918	164	21	events	event	NOUN
dpc-5918	164	22	per	per	ADP
dpc-5918	164	23	sample	sample	NOUN
dpc-5918	164	24	,	,	PUNCT
dpc-5918	164	25	and	and	CCONJ
dpc-5918	164	26	gating	gate	VERB
dpc-5918	164	27	strategies	strategy	NOUN
dpc-5918	164	28	were	be	AUX
dpc-5918	164	29	consistently	consistently	ADV
dpc-5918	164	30	applied	apply	VERB
dpc-5918	164	31	across	across	ADP
dpc-5918	164	32	replicates	replicate	NOUN
dpc-5918	164	33	.	.	PUNCT
dpc-5918	165	1	all	all	DET
dpc-5918	165	2	statistical	statistical	ADJ
dpc-5918	165	3	analyses	analysis	NOUN
dpc-5918	165	4	were	be	AUX
dpc-5918	165	5	original	original	ADJ
dpc-5918	165	6	article	article	NOUN
dpc-5918	165	7	|	|	ADV
dpc-5918	165	8	dermatol	dermatol	ADJ
dpc-5918	165	9	pract	pract	NOUN
dpc-5918	165	10	concept	concept	NOUN
dpc-5918	165	11	.	.	PUNCT
dpc-5918	166	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	166	2	5	5	NUM
dpc-5918	166	3	assay	assay	VERB
dpc-5918	166	4	.	.	PUNCT
dpc-5918	167	1	cells	cell	NOUN
dpc-5918	167	2	treated	treat	VERB
dpc-5918	167	3	with	with	ADP
dpc-5918	167	4	75	75	NUM
dpc-5918	167	5	nm	nm	ADJ
dpc-5918	167	6	grwd1	grwd1	NOUN
dpc-5918	168	1	sirna	sirna	PROPN
dpc-5918	168	2	were	be	AUX
dpc-5918	168	3	stained	stain	VERB
dpc-5918	168	4	after	after	ADP
dpc-5918	168	5	two	two	NUM
dpc-5918	168	6	weeks	week	NOUN
dpc-5918	168	7	,	,	PUNCT
dpc-5918	168	8	and	and	CCONJ
dpc-5918	168	9	the	the	DET
dpc-5918	168	10	number	number	NOUN
dpc-5918	168	11	of	of	ADP
dpc-5918	168	12	colonies	colony	NOUN
dpc-5918	168	13	was	be	AUX
dpc-5918	168	14	quantified	quantify	VERB
dpc-5918	168	15	.	.	PUNCT
dpc-5918	169	1	the	the	DET
dpc-5918	169	2	results	result	NOUN
dpc-5918	169	3	showed	show	VERB
dpc-5918	169	4	a	a	DET
dpc-5918	169	5	74.4	74.4	NUM
dpc-5918	169	6	%	%	NOUN
dpc-5918	169	7	decrease	decrease	NOUN
dpc-5918	169	8	in	in	ADP
dpc-5918	169	9	colony	colony	NOUN
dpc-5918	169	10	formation	formation	NOUN
dpc-5918	169	11	ability	ability	NOUN
dpc-5918	169	12	in	in	ADP
dpc-5918	169	13	treated	treat	VERB
dpc-5918	169	14	cells	cell	NOUN
dpc-5918	169	15	(	(	PUNCT
dpc-5918	169	16	figure	figure	NOUN
dpc-5918	169	17	2d	2d	NOUN
dpc-5918	169	18	)	)	PUNCT
dpc-5918	169	19	.	.	PUNCT
dpc-5918	170	1	our	our	PRON
dpc-5918	170	2	findings	finding	NOUN
dpc-5918	170	3	support	support	VERB
dpc-5918	170	4	the	the	DET
dpc-5918	170	5	conclusion	conclusion	NOUN
dpc-5918	170	6	that	that	SCONJ
dpc-5918	170	7	grwd1	grwd1	NOUN
dpc-5918	170	8	overexpression	overexpression	NOUN
dpc-5918	170	9	promotes	promote	VERB
dpc-5918	170	10	cell	cell	NOUN
dpc-5918	170	11	proliferation	proliferation	NOUN
dpc-5918	170	12	.	.	PUNCT
dpc-5918	171	1	grwd1	grwd1	NOUN
dpc-5918	171	2	knockdown	knockdown	NOUN
dpc-5918	171	3	leads	lead	VERB
dpc-5918	171	4	to	to	ADP
dpc-5918	171	5	an	an	DET
dpc-5918	171	6	increase	increase	NOUN
dpc-5918	171	7	in	in	ADP
dpc-5918	171	8	cell	cell	NOUN
dpc-5918	171	9	death	death	NOUN
dpc-5918	171	10	in	in	ADP
dpc-5918	171	11	a	a	DET
dpc-5918	171	12	study	study	NOUN
dpc-5918	171	13	,	,	PUNCT
dpc-5918	171	14	grwd1	grwd1	PROPN
dpc-5918	171	15	was	be	AUX
dpc-5918	171	16	found	find	VERB
dpc-5918	171	17	to	to	PART
dpc-5918	171	18	support	support	VERB
dpc-5918	171	19	cell	cell	NOUN
dpc-5918	171	20	colony	colony	NOUN
dpc-5918	171	21	formation	formation	NOUN
dpc-5918	171	22	by	by	ADP
dpc-5918	171	23	affecting	affect	VERB
dpc-5918	171	24	the	the	DET
dpc-5918	171	25	expression	expression	NOUN
dpc-5918	171	26	of	of	ADP
dpc-5918	171	27	cyclin	cyclin	PROPN
dpc-5918	171	28	b1	b1	PROPN
dpc-5918	171	29	,	,	PUNCT
dpc-5918	171	30	cdk1	cdk1	PROPN
dpc-5918	171	31	,	,	PUNCT
dpc-5918	171	32	and	and	CCONJ
dpc-5918	171	33	p27	p27	NOUN
dpc-5918	171	34	and	and	CCONJ
dpc-5918	171	35	inducing	induce	VERB
dpc-5918	171	36	the	the	DET
dpc-5918	171	37	g2	g2	PROPN
dpc-5918	171	38	/	/	SYM
dpc-5918	171	39	m	m	PROPN
dpc-5918	171	40	transition	transition	NOUN
dpc-5918	171	41	[	[	X
dpc-5918	171	42	13	13	NUM
dpc-5918	171	43	]	]	PUNCT
dpc-5918	171	44	.	.	PUNCT
dpc-5918	172	1	additionally	additionally	ADV
dpc-5918	172	2	,	,	PUNCT
dpc-5918	172	3	research	research	NOUN
dpc-5918	172	4	on	on	ADP
dpc-5918	172	5	gastric	gastric	ADJ
dpc-5918	172	6	cancer	cancer	NOUN
dpc-5918	172	7	(	(	PUNCT
dpc-5918	172	8	gc	gc	PROPN
dpc-5918	172	9	)	)	PUNCT
dpc-5918	172	10	demonstrated	demonstrate	VERB
dpc-5918	172	11	that	that	SCONJ
dpc-5918	172	12	grwd1	grwd1	NOUN
dpc-5918	172	13	overexpression	overexpression	NOUN
dpc-5918	172	14	promotes	promote	VERB
dpc-5918	172	15	the	the	DET
dpc-5918	172	16	proliferation	proliferation	NOUN
dpc-5918	172	17	,	,	PUNCT
dpc-5918	172	18	migration	migration	NOUN
dpc-5918	172	19	,	,	PUNCT
dpc-5918	172	20	and	and	CCONJ
dpc-5918	172	21	invasion	invasion	NOUN
dpc-5918	172	22	of	of	ADP
dpc-5918	172	23	gastric	gastric	ADJ
dpc-5918	172	24	cancer	cancer	NOUN
dpc-5918	172	25	cells	cell	NOUN
dpc-5918	172	26	in	in	ADP
dpc-5918	172	27	vitro	vitro	X
dpc-5918	173	1	[	[	X
dpc-5918	173	2	15	15	NUM
dpc-5918	173	3	]	]	PUNCT
dpc-5918	173	4	.	.	PUNCT
dpc-5918	174	1	to	to	PART
dpc-5918	174	2	determine	determine	VERB
dpc-5918	174	3	whether	whether	SCONJ
dpc-5918	174	4	the	the	DET
dpc-5918	174	5	reduction	reduction	NOUN
dpc-5918	174	6	in	in	ADP
dpc-5918	174	7	cell	cell	NOUN
dpc-5918	174	8	proliferation	proliferation	NOUN
dpc-5918	174	9	due	due	ADP
dpc-5918	174	10	to	to	ADP
dpc-5918	174	11	grwd1	grwd1	NOUN
dpc-5918	174	12	suppression	suppression	NOUN
dpc-5918	174	13	was	be	AUX
dpc-5918	174	14	caused	cause	VERB
dpc-5918	174	15	by	by	ADP
dpc-5918	174	16	slowed	slow	VERB
dpc-5918	174	17	cell	cell	NOUN
dpc-5918	174	18	division	division	NOUN
dpc-5918	174	19	or	or	CCONJ
dpc-5918	174	20	increased	increase	VERB
dpc-5918	174	21	cell	cell	NOUN
dpc-5918	174	22	death	death	NOUN
dpc-5918	174	23	,	,	PUNCT
dpc-5918	174	24	cell	cell	NOUN
dpc-5918	174	25	cycle	cycle	NOUN
dpc-5918	174	26	analysis	analysis	NOUN
dpc-5918	174	27	was	be	AUX
dpc-5918	174	28	first	first	ADV
dpc-5918	174	29	performed	perform	VERB
dpc-5918	174	30	using	use	VERB
dpc-5918	174	31	flow	flow	NOUN
dpc-5918	174	32	cytometry	cytometry	NOUN
dpc-5918	174	33	.	.	PUNCT
dpc-5918	175	1	cells	cell	NOUN
dpc-5918	175	2	treated	treat	VERB
dpc-5918	175	3	with	with	ADP
dpc-5918	175	4	grwd1	grwd1	ADJ
dpc-5918	175	5	-	-	PUNCT
dpc-5918	175	6	specific	specific	ADJ
dpc-5918	175	7	sirna	sirna	PROPN
dpc-5918	175	8	and	and	CCONJ
dpc-5918	175	9	control	control	PROPN
dpc-5918	175	10	sirna	sirna	PROPN
dpc-5918	175	11	for	for	ADP
dpc-5918	175	12	72	72	NUM
dpc-5918	175	13	hours	hour	NOUN
dpc-5918	175	14	were	be	AUX
dpc-5918	175	15	stained	stain	VERB
dpc-5918	175	16	with	with	ADP
dpc-5918	175	17	pi	pi	NOUN
dpc-5918	175	18	and	and	CCONJ
dpc-5918	175	19	analyzed	analyze	VERB
dpc-5918	175	20	by	by	ADP
dpc-5918	175	21	grwd1	grwd1	NOUN
dpc-5918	175	22	is	be	AUX
dpc-5918	175	23	expressed	express	VERB
dpc-5918	175	24	in	in	ADP
dpc-5918	175	25	melanoma	melanoma	NOUN
dpc-5918	175	26	cells	cell	NOUN
dpc-5918	175	27	and	and	CCONJ
dpc-5918	175	28	plays	play	VERB
dpc-5918	175	29	a	a	DET
dpc-5918	175	30	role	role	NOUN
dpc-5918	175	31	in	in	ADP
dpc-5918	175	32	cell	cell	NOUN
dpc-5918	175	33	proliferation	proliferation	NOUN
dpc-5918	175	34	grwd1	grwd1	NOUN
dpc-5918	175	35	is	be	AUX
dpc-5918	175	36	expressed	express	VERB
dpc-5918	175	37	at	at	ADP
dpc-5918	175	38	higher	high	ADJ
dpc-5918	175	39	levels	level	NOUN
dpc-5918	175	40	in	in	ADP
dpc-5918	175	41	many	many	ADJ
dpc-5918	175	42	cancer	cancer	NOUN
dpc-5918	175	43	cells	cell	NOUN
dpc-5918	175	44	compared	compare	VERB
dpc-5918	175	45	to	to	ADP
dpc-5918	175	46	normal	normal	ADJ
dpc-5918	175	47	tissues	tissue	NOUN
dpc-5918	175	48	.	.	PUNCT
dpc-5918	176	1	in	in	ADP
dpc-5918	176	2	breast	breast	NOUN
dpc-5918	176	3	cancer	cancer	NOUN
dpc-5918	176	4	cells	cell	NOUN
dpc-5918	176	5	,	,	PUNCT
dpc-5918	176	6	grwd1	grwd1	NOUN
dpc-5918	176	7	mrna	mrna	NOUN
dpc-5918	176	8	and	and	CCONJ
dpc-5918	176	9	protein	protein	NOUN
dpc-5918	176	10	levels	level	NOUN
dpc-5918	176	11	have	have	AUX
dpc-5918	176	12	been	be	AUX
dpc-5918	176	13	found	find	VERB
dpc-5918	176	14	to	to	PART
dpc-5918	176	15	be	be	AUX
dpc-5918	176	16	elevated	elevate	VERB
dpc-5918	176	17	compared	compare	VERB
dpc-5918	176	18	to	to	ADP
dpc-5918	176	19	normal	normal	ADJ
dpc-5918	176	20	human	human	ADJ
dpc-5918	176	21	breast	breast	NOUN
dpc-5918	176	22	epithelial	epithelial	ADJ
dpc-5918	176	23	cells	cell	NOUN
dpc-5918	176	24	[	[	X
dpc-5918	176	25	14	14	NUM
dpc-5918	176	26	]	]	PUNCT
dpc-5918	176	27	.	.	PUNCT
dpc-5918	177	1	wang	wang	PROPN
dpc-5918	177	2	et	et	PROPN
dpc-5918	177	3	al	al	PROPN
dpc-5918	177	4	.	.	PROPN
dpc-5918	177	5	reported	report	VERB
dpc-5918	177	6	that	that	SCONJ
dpc-5918	177	7	grwd1	grwd1	NOUN
dpc-5918	177	8	is	be	AUX
dpc-5918	177	9	overexpressed	overexpresse	VERB
dpc-5918	177	10	in	in	ADP
dpc-5918	177	11	non	non	ADJ
dpc-5918	177	12	-	-	ADJ
dpc-5918	177	13	small	small	ADJ
dpc-5918	177	14	cell	cell	NOUN
dpc-5918	177	15	lung	lung	NOUN
dpc-5918	177	16	cancer	cancer	NOUN
dpc-5918	177	17	(	(	PUNCT
dpc-5918	177	18	nsclc	nsclc	NOUN
dpc-5918	177	19	)	)	PUNCT
dpc-5918	178	1	[	[	X
dpc-5918	178	2	13	13	NUM
dpc-5918	178	3	]	]	PUNCT
dpc-5918	178	4	.	.	PUNCT
dpc-5918	179	1	since	since	SCONJ
dpc-5918	179	2	there	there	PRON
dpc-5918	179	3	was	be	VERB
dpc-5918	179	4	no	no	DET
dpc-5918	179	5	prior	prior	ADJ
dpc-5918	179	6	study	study	NOUN
dpc-5918	179	7	demonstrating	demonstrate	VERB
dpc-5918	179	8	grwd1	grwd1	NOUN
dpc-5918	179	9	expression	expression	NOUN
dpc-5918	179	10	in	in	ADP
dpc-5918	179	11	melanoma	melanoma	NOUN
dpc-5918	179	12	cells	cell	NOUN
dpc-5918	179	13	,	,	PUNCT
dpc-5918	179	14	we	we	PRON
dpc-5918	179	15	first	first	ADV
dpc-5918	179	16	confirmed	confirm	VERB
dpc-5918	179	17	grwd1	grwd1	NOUN
dpc-5918	179	18	expression	expression	NOUN
dpc-5918	179	19	in	in	ADP
dpc-5918	179	20	a2058	a2058	ADJ
dpc-5918	179	21	cells	cell	NOUN
dpc-5918	179	22	,	,	PUNCT
dpc-5918	179	23	a	a	DET
dpc-5918	179	24	highly	highly	ADV
dpc-5918	179	25	invasive	invasive	ADJ
dpc-5918	179	26	melanoma	melanoma	NOUN
dpc-5918	179	27	cell	cell	NOUN
dpc-5918	179	28	line	line	NOUN
dpc-5918	179	29	(	(	PUNCT
dpc-5918	179	30	figure	figure	NOUN
dpc-5918	179	31	2a	2a	NUM
dpc-5918	179	32	)	)	PUNCT
dpc-5918	179	33	.	.	PUNCT
dpc-5918	180	1	to	to	PART
dpc-5918	180	2	test	test	VERB
dpc-5918	180	3	our	our	PRON
dpc-5918	180	4	hypothesis	hypothesis	NOUN
dpc-5918	180	5	that	that	DET
dpc-5918	180	6	suppression	suppression	NOUN
dpc-5918	180	7	of	of	ADP
dpc-5918	180	8	grwd1	grwd1	NOUN
dpc-5918	180	9	expression	expression	NOUN
dpc-5918	180	10	would	would	AUX
dpc-5918	180	11	reduce	reduce	VERB
dpc-5918	180	12	melanoma	melanoma	NOUN
dpc-5918	180	13	cell	cell	NOUN
dpc-5918	180	14	proliferation	proliferation	NOUN
dpc-5918	180	15	,	,	PUNCT
dpc-5918	180	16	we	we	PRON
dpc-5918	180	17	used	use	VERB
dpc-5918	180	18	grwd1	grwd1	ADJ
dpc-5918	180	19	-	-	PUNCT
dpc-5918	180	20	specific	specific	ADJ
dpc-5918	180	21	sirna	sirna	PROPN
dpc-5918	180	22	to	to	PART
dpc-5918	180	23	inhibit	inhibit	VERB
dpc-5918	180	24	grwd1	grwd1	NOUN
dpc-5918	180	25	expression	expression	NOUN
dpc-5918	180	26	by	by	ADP
dpc-5918	180	27	95	95	NUM
dpc-5918	180	28	%	%	NOUN
dpc-5918	180	29	.	.	PUNCT
dpc-5918	181	1	suppression	suppression	NOUN
dpc-5918	181	2	of	of	ADP
dpc-5918	181	3	grwd1	grwd1	NOUN
dpc-5918	181	4	expression	expression	NOUN
dpc-5918	181	5	led	lead	VERB
dpc-5918	181	6	to	to	ADP
dpc-5918	181	7	a	a	DET
dpc-5918	181	8	noticeable	noticeable	ADJ
dpc-5918	181	9	decrease	decrease	NOUN
dpc-5918	181	10	in	in	ADP
dpc-5918	181	11	cell	cell	NOUN
dpc-5918	181	12	viability	viability	NOUN
dpc-5918	181	13	(	(	PUNCT
dpc-5918	181	14	figure	figure	NOUN
dpc-5918	181	15	2b	2b	NOUN
dpc-5918	181	16	)	)	PUNCT
dpc-5918	181	17	.	.	PUNCT
dpc-5918	182	1	after	after	ADP
dpc-5918	182	2	72	72	NUM
dpc-5918	182	3	hours	hour	NOUN
dpc-5918	182	4	of	of	ADP
dpc-5918	182	5	knockdown	knockdown	NOUN
dpc-5918	182	6	,	,	PUNCT
dpc-5918	182	7	a	a	DET
dpc-5918	182	8	proliferation	proliferation	NOUN
dpc-5918	182	9	assay	assay	NOUN
dpc-5918	182	10	showed	show	VERB
dpc-5918	182	11	a	a	DET
dpc-5918	182	12	63	63	NUM
dpc-5918	182	13	%	%	NOUN
dpc-5918	182	14	reduction	reduction	NOUN
dpc-5918	182	15	in	in	ADP
dpc-5918	182	16	cell	cell	NOUN
dpc-5918	182	17	proliferation	proliferation	NOUN
dpc-5918	182	18	in	in	ADP
dpc-5918	182	19	the	the	DET
dpc-5918	182	20	grwd1	grwd1	PROPN
dpc-5918	182	21	sirna	sirna	PROPN
dpc-5918	182	22	-	-	PUNCT
dpc-5918	182	23	treated	treat	VERB
dpc-5918	182	24	group	group	NOUN
dpc-5918	182	25	(	(	PUNCT
dpc-5918	182	26	figure	figure	NOUN
dpc-5918	182	27	2c	2c	NUM
dpc-5918	182	28	)	)	PUNCT
dpc-5918	182	29	.	.	PUNCT
dpc-5918	183	1	this	this	DET
dpc-5918	183	2	reduction	reduction	NOUN
dpc-5918	183	3	in	in	ADP
dpc-5918	183	4	proliferative	proliferative	ADJ
dpc-5918	183	5	capacity	capacity	NOUN
dpc-5918	183	6	was	be	AUX
dpc-5918	183	7	further	far	ADV
dpc-5918	183	8	emphasized	emphasize	VERB
dpc-5918	183	9	by	by	ADP
dpc-5918	183	10	a	a	DET
dpc-5918	183	11	colony	colony	NOUN
dpc-5918	183	12	formation	formation	NOUN
dpc-5918	183	13	figure	figure	NOUN
dpc-5918	183	14	1	1	NUM
dpc-5918	183	15	.	.	PUNCT
dpc-5918	184	1	grwd1	grwd1	NOUN
dpc-5918	184	2	expression	expression	NOUN
dpc-5918	184	3	and	and	CCONJ
dpc-5918	184	4	survival	survival	NOUN
dpc-5918	184	5	analysis	analysis	NOUN
dpc-5918	184	6	in	in	ADP
dpc-5918	184	7	melanoma	melanoma	NOUN
dpc-5918	184	8	patients	patient	NOUN
dpc-5918	184	9	.	.	PUNCT
dpc-5918	185	1	(	(	PUNCT
dpc-5918	185	2	a	a	X
dpc-5918	185	3	)	)	PUNCT
dpc-5918	185	4	grwd1	grwd1	NOUN
dpc-5918	185	5	expression	expression	NOUN
dpc-5918	185	6	levels	level	NOUN
dpc-5918	185	7	in	in	ADP
dpc-5918	185	8	metastatic	metastatic	ADJ
dpc-5918	185	9	and	and	CCONJ
dpc-5918	185	10	primary	primary	ADJ
dpc-5918	185	11	melanoma	melanoma	NOUN
dpc-5918	185	12	tumors	tumor	NOUN
dpc-5918	185	13	based	base	VERB
dpc-5918	185	14	on	on	ADP
dpc-5918	185	15	tcga	tcga	PROPN
dpc-5918	185	16	data	datum	NOUN
dpc-5918	185	17	.	.	PUNCT
dpc-5918	186	1	no	no	DET
dpc-5918	186	2	significant	significant	ADJ
dpc-5918	186	3	difference	difference	NOUN
dpc-5918	186	4	was	be	AUX
dpc-5918	186	5	observed	observe	VERB
dpc-5918	186	6	(	(	PUNCT
dpc-5918	186	7	p=0.984	p=0.984	X
dpc-5918	186	8	)	)	PUNCT
dpc-5918	186	9	.	.	PUNCT
dpc-5918	187	1	(	(	PUNCT
dpc-5918	187	2	b	b	X
dpc-5918	187	3	)	)	PUNCT
dpc-5918	187	4	kaplan	kaplan	PROPN
dpc-5918	187	5	-	-	PUNCT
dpc-5918	187	6	meier	meier	PROPN
dpc-5918	187	7	survival	survival	NOUN
dpc-5918	187	8	analysis	analysis	NOUN
dpc-5918	187	9	of	of	ADP
dpc-5918	187	10	melanoma	melanoma	NOUN
dpc-5918	187	11	patients	patient	NOUN
dpc-5918	187	12	stratified	stratify	VERB
dpc-5918	187	13	by	by	ADP
dpc-5918	187	14	grwd1	grwd1	NOUN
dpc-5918	187	15	expression	expression	NOUN
dpc-5918	187	16	.	.	PUNCT
dpc-5918	188	1	high	high	ADJ
dpc-5918	188	2	grwd1	grwd1	NOUN
dpc-5918	188	3	expression	expression	NOUN
dpc-5918	188	4	correlates	correlate	VERB
dpc-5918	188	5	with	with	ADP
dpc-5918	188	6	significantly	significantly	ADV
dpc-5918	188	7	reduced	reduce	VERB
dpc-5918	188	8	survival	survival	NOUN
dpc-5918	188	9	(	(	PUNCT
dpc-5918	188	10	p<0.001	p<0.001	PROPN
dpc-5918	188	11	)	)	PUNCT
dpc-5918	188	12	.	.	PUNCT
dpc-5918	189	1	(	(	PUNCT
dpc-5918	189	2	c	c	X
dpc-5918	189	3	)	)	PUNCT
dpc-5918	189	4	survival	survival	NOUN
dpc-5918	189	5	probability	probability	NOUN
dpc-5918	189	6	analysis	analysis	NOUN
dpc-5918	189	7	for	for	ADP
dpc-5918	189	8	primary	primary	ADJ
dpc-5918	189	9	melanoma	melanoma	NOUN
dpc-5918	189	10	cases	case	NOUN
dpc-5918	189	11	based	base	VERB
dpc-5918	189	12	on	on	ADP
dpc-5918	189	13	grwd1	grwd1	NOUN
dpc-5918	189	14	expression	expression	NOUN
dpc-5918	189	15	.	.	PUNCT
dpc-5918	190	1	a	a	DET
dpc-5918	190	2	trend	trend	NOUN
dpc-5918	190	3	toward	toward	ADP
dpc-5918	190	4	poorer	poor	ADJ
dpc-5918	190	5	survival	survival	NOUN
dpc-5918	190	6	in	in	ADP
dpc-5918	190	7	high	high	ADJ
dpc-5918	190	8	-	-	PUNCT
dpc-5918	190	9	grwd1	grwd1	NOUN
dpc-5918	190	10	cases	case	NOUN
dpc-5918	190	11	was	be	AUX
dpc-5918	190	12	observed	observe	VERB
dpc-5918	190	13	despite	despite	SCONJ
dpc-5918	190	14	the	the	DET
dpc-5918	190	15	statistical	statistical	ADJ
dpc-5918	190	16	insignificance	insignificance	NOUN
dpc-5918	190	17	(	(	PUNCT
dpc-5918	190	18	p=0.073	p=0.073	NOUN
dpc-5918	190	19	)	)	PUNCT
dpc-5918	190	20	.	.	PUNCT
dpc-5918	191	1	(	(	PUNCT
dpc-5918	191	2	d	d	X
dpc-5918	191	3	)	)	PUNCT
dpc-5918	191	4	survival	survival	NOUN
dpc-5918	191	5	analysis	analysis	NOUN
dpc-5918	191	6	of	of	ADP
dpc-5918	191	7	metastatic	metastatic	ADJ
dpc-5918	191	8	melanoma	melanoma	NOUN
dpc-5918	191	9	cases	case	NOUN
dpc-5918	191	10	.	.	PUNCT
dpc-5918	192	1	high	high	ADJ
dpc-5918	192	2	grwd1	grwd1	NOUN
dpc-5918	192	3	expression	expression	NOUN
dpc-5918	192	4	is	be	AUX
dpc-5918	192	5	significantly	significantly	ADV
dpc-5918	192	6	associated	associate	VERB
dpc-5918	192	7	with	with	ADP
dpc-5918	192	8	decreased	decrease	VERB
dpc-5918	192	9	survival	survival	NOUN
dpc-5918	192	10	(	(	PUNCT
dpc-5918	192	11	p<0.001	p<0.001	PROPN
dpc-5918	192	12	)	)	PUNCT
dpc-5918	192	13	.	.	PUNCT
dpc-5918	193	1	6	6	NUM
dpc-5918	193	2	original	original	ADJ
dpc-5918	193	3	article	article	NOUN
dpc-5918	193	4	|	|	ADV
dpc-5918	193	5	dermatol	dermatol	ADJ
dpc-5918	193	6	pract	pract	NOUN
dpc-5918	193	7	concept	concept	NOUN
dpc-5918	193	8	.	.	PUNCT
dpc-5918	194	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	194	2	figure	figure	NOUN
dpc-5918	194	3	2	2	NUM
dpc-5918	194	4	.	.	PUNCT
dpc-5918	194	5	grwd1	grwd1	NOUN
dpc-5918	194	6	knockdown	knockdown	NOUN
dpc-5918	194	7	reduces	reduce	VERB
dpc-5918	194	8	melanoma	melanoma	NOUN
dpc-5918	194	9	cell	cell	NOUN
dpc-5918	194	10	proliferation	proliferation	NOUN
dpc-5918	194	11	and	and	CCONJ
dpc-5918	194	12	colony	colony	NOUN
dpc-5918	194	13	formation	formation	NOUN
dpc-5918	194	14	.	.	PUNCT
dpc-5918	195	1	(	(	PUNCT
dpc-5918	195	2	a	a	X
dpc-5918	195	3	)	)	PUNCT
dpc-5918	195	4	western	western	ADJ
dpc-5918	195	5	blot	blot	NOUN
dpc-5918	195	6	analysis	analysis	NOUN
dpc-5918	195	7	confirming	confirm	VERB
dpc-5918	195	8	grwd1	grwd1	NOUN
dpc-5918	195	9	knockdown	knockdown	NOUN
dpc-5918	195	10	in	in	ADP
dpc-5918	195	11	a2058	a2058	NUM
dpc-5918	195	12	melanoma	melanoma	NOUN
dpc-5918	195	13	cells	cell	NOUN
dpc-5918	195	14	treated	treat	VERB
dpc-5918	195	15	with	with	ADP
dpc-5918	195	16	grwd1	grwd1	PROPN
dpc-5918	195	17	sirna	sirna	PROPN
dpc-5918	195	18	.	.	PUNCT
dpc-5918	196	1	(	(	PUNCT
dpc-5918	196	2	b	b	X
dpc-5918	196	3	)	)	PUNCT
dpc-5918	196	4	phase	phase	NOUN
dpc-5918	196	5	-	-	PUNCT
dpc-5918	196	6	contrast	contrast	NOUN
dpc-5918	196	7	microscopy	microscopy	NOUN
dpc-5918	196	8	images	image	NOUN
dpc-5918	196	9	showing	show	VERB
dpc-5918	196	10	reduced	reduce	VERB
dpc-5918	196	11	cell	cell	NOUN
dpc-5918	196	12	density	density	NOUN
dpc-5918	196	13	following	follow	VERB
dpc-5918	196	14	grwd1	grwd1	NOUN
dpc-5918	196	15	knockdown	knockdown	NOUN
dpc-5918	196	16	compared	compare	VERB
dpc-5918	196	17	to	to	ADP
dpc-5918	196	18	control	control	NOUN
dpc-5918	196	19	.	.	PUNCT
dpc-5918	197	1	(	(	PUNCT
dpc-5918	197	2	c	c	X
dpc-5918	197	3	)	)	PUNCT
dpc-5918	197	4	mts	mts	NOUN
dpc-5918	197	5	assay	assay	NOUN
dpc-5918	197	6	results	result	NOUN
dpc-5918	197	7	demonstrate	demonstrate	VERB
dpc-5918	197	8	a	a	DET
dpc-5918	197	9	significant	significant	ADJ
dpc-5918	197	10	decrease	decrease	NOUN
dpc-5918	197	11	in	in	ADP
dpc-5918	197	12	cell	cell	NOUN
dpc-5918	197	13	viability	viability	NOUN
dpc-5918	197	14	after	after	ADP
dpc-5918	197	15	grwd1	grwd1	NOUN
dpc-5918	197	16	knockdown	knockdown	NOUN
dpc-5918	197	17	(	(	PUNCT
dpc-5918	197	18	*	*	PUNCT
dpc-5918	197	19	*	*	PUNCT
dpc-5918	197	20	*	*	PUNCT
dpc-5918	197	21	*	*	PUNCT
dpc-5918	197	22	p<0.001	p<0.001	ADJ
dpc-5918	197	23	)	)	PUNCT
dpc-5918	197	24	.	.	PUNCT
dpc-5918	198	1	(	(	PUNCT
dpc-5918	198	2	d	d	X
dpc-5918	198	3	)	)	PUNCT
dpc-5918	198	4	colony	colony	NOUN
dpc-5918	198	5	formation	formation	NOUN
dpc-5918	198	6	assay	assay	NOUN
dpc-5918	198	7	shows	show	VERB
dpc-5918	198	8	a	a	DET
dpc-5918	198	9	reduction	reduction	NOUN
dpc-5918	198	10	in	in	ADP
dpc-5918	198	11	the	the	DET
dpc-5918	198	12	number	number	NOUN
dpc-5918	198	13	of	of	ADP
dpc-5918	198	14	colonies	colony	NOUN
dpc-5918	198	15	formed	form	VERB
dpc-5918	198	16	by	by	ADP
dpc-5918	198	17	grwd1	grwd1	PROPN
dpc-5918	198	18	sirna	sirna	PROPN
dpc-5918	198	19	-	-	PUNCT
dpc-5918	198	20	treated	treat	VERB
dpc-5918	198	21	cells	cell	NOUN
dpc-5918	198	22	.	.	PUNCT
dpc-5918	199	1	statistical	statistical	ADJ
dpc-5918	199	2	analysis	analysis	NOUN
dpc-5918	199	3	was	be	AUX
dpc-5918	199	4	performed	perform	VERB
dpc-5918	199	5	using	use	VERB
dpc-5918	199	6	one	one	NUM
dpc-5918	199	7	-	-	PUNCT
dpc-5918	199	8	way	way	NOUN
dpc-5918	199	9	anova	anova	PROPN
dpc-5918	199	10	followed	follow	VERB
dpc-5918	199	11	by	by	ADP
dpc-5918	199	12	tukey	tukey	PROPN
dpc-5918	199	13	’s	’s	PART
dpc-5918	199	14	post	post	X
dpc-5918	199	15	hoc	hoc	X
dpc-5918	199	16	test	test	NOUN
dpc-5918	199	17	(	(	PUNCT
dpc-5918	199	18	n=3	n=3	NOUN
dpc-5918	199	19	)	)	PUNCT
dpc-5918	199	20	.	.	PUNCT
dpc-5918	200	1	data	datum	NOUN
dpc-5918	200	2	are	be	AUX
dpc-5918	200	3	shown	show	VERB
dpc-5918	200	4	as	as	ADP
dpc-5918	200	5	mean	mean	NOUN
dpc-5918	200	6	±	±	NUM
dpc-5918	200	7	sd	sd	NOUN
dpc-5918	200	8	.	.	PUNCT
dpc-5918	201	1	figure	figure	NOUN
dpc-5918	201	2	3	3	NUM
dpc-5918	201	3	.	.	PUNCT
dpc-5918	201	4	grwd1	grwd1	NOUN
dpc-5918	201	5	knockdown	knockdown	NOUN
dpc-5918	201	6	induces	induce	VERB
dpc-5918	201	7	apoptosis	apoptosis	NOUN
dpc-5918	201	8	in	in	ADP
dpc-5918	201	9	melanoma	melanoma	NOUN
dpc-5918	201	10	cells	cell	NOUN
dpc-5918	201	11	.	.	PUNCT
dpc-5918	202	1	(	(	PUNCT
dpc-5918	202	2	a	a	X
dpc-5918	202	3	)	)	PUNCT
dpc-5918	202	4	flow	flow	NOUN
dpc-5918	202	5	cytometric	cytometric	ADJ
dpc-5918	202	6	analysis	analysis	NOUN
dpc-5918	202	7	of	of	ADP
dpc-5918	202	8	cell	cell	NOUN
dpc-5918	202	9	cycle	cycle	NOUN
dpc-5918	202	10	distribution	distribution	NOUN
dpc-5918	202	11	.	.	PUNCT
dpc-5918	203	1	grwd1	grwd1	NOUN
dpc-5918	203	2	knockdown	knockdown	NOUN
dpc-5918	203	3	significantly	significantly	ADV
dpc-5918	203	4	increases	increase	VERB
dpc-5918	203	5	the	the	DET
dpc-5918	203	6	sub	sub	ADJ
dpc-5918	203	7	-	-	ADJ
dpc-5918	203	8	g1	g1	ADJ
dpc-5918	203	9	population	population	NOUN
dpc-5918	203	10	,	,	PUNCT
dpc-5918	203	11	indicating	indicate	VERB
dpc-5918	203	12	apoptotic	apoptotic	ADJ
dpc-5918	203	13	cell	cell	NOUN
dpc-5918	203	14	death	death	NOUN
dpc-5918	203	15	(	(	PUNCT
dpc-5918	203	16	*	*	PUNCT
dpc-5918	203	17	*	*	PUNCT
dpc-5918	203	18	*	*	PUNCT
dpc-5918	203	19	*	*	PUNCT
dpc-5918	203	20	p<0.001	p<0.001	ADJ
dpc-5918	203	21	)	)	PUNCT
dpc-5918	203	22	.	.	PUNCT
dpc-5918	204	1	(	(	PUNCT
dpc-5918	204	2	b	b	X
dpc-5918	204	3	)	)	PUNCT
dpc-5918	204	4	annexin	annexin	NOUN
dpc-5918	204	5	v	v	NOUN
dpc-5918	204	6	-	-	PUNCT
dpc-5918	204	7	pi	pi	NOUN
dpc-5918	204	8	staining	stain	VERB
dpc-5918	204	9	showing	show	VERB
dpc-5918	204	10	a	a	DET
dpc-5918	204	11	significant	significant	ADJ
dpc-5918	204	12	increase	increase	NOUN
dpc-5918	204	13	in	in	ADP
dpc-5918	204	14	apoptotic	apoptotic	ADJ
dpc-5918	204	15	cell	cell	NOUN
dpc-5918	204	16	population	population	NOUN
dpc-5918	204	17	following	follow	VERB
dpc-5918	204	18	grwd1	grwd1	NOUN
dpc-5918	204	19	knockdown	knockdown	NOUN
dpc-5918	204	20	(	(	PUNCT
dpc-5918	204	21	*	*	PUNCT
dpc-5918	204	22	*	*	PUNCT
dpc-5918	204	23	*	*	PUNCT
dpc-5918	204	24	*	*	PUNCT
dpc-5918	204	25	p<0.001	p<0.001	ADJ
dpc-5918	204	26	)	)	PUNCT
dpc-5918	204	27	.	.	PUNCT
dpc-5918	205	1	(	(	PUNCT
dpc-5918	205	2	c	c	X
dpc-5918	205	3	)	)	PUNCT
dpc-5918	205	4	caspase-3	caspase-3	NUM
dpc-5918	205	5	activation	activation	NOUN
dpc-5918	205	6	assay	assay	VERB
dpc-5918	205	7	confirming	confirm	VERB
dpc-5918	205	8	apoptosis	apoptosis	NOUN
dpc-5918	205	9	induction	induction	NOUN
dpc-5918	205	10	in	in	ADP
dpc-5918	205	11	grwd1	grwd1	PROPN
dpc-5918	205	12	sirna	sirna	PROPN
dpc-5918	205	13	-	-	PUNCT
dpc-5918	205	14	treated	treat	VERB
dpc-5918	205	15	cells	cell	NOUN
dpc-5918	205	16	flow	flow	VERB
dpc-5918	205	17	cytometry	cytometry	NOUN
dpc-5918	205	18	data	datum	NOUN
dpc-5918	205	19	represent	represent	VERB
dpc-5918	205	20	mean	mean	NOUN
dpc-5918	205	21	±	±	NUM
dpc-5918	205	22	sd	sd	NOUN
dpc-5918	205	23	from	from	ADP
dpc-5918	205	24	three	three	NUM
dpc-5918	205	25	independent	independent	ADJ
dpc-5918	205	26	experiments	experiment	NOUN
dpc-5918	205	27	.	.	PUNCT
dpc-5918	206	1	statistical	statistical	ADJ
dpc-5918	206	2	comparisons	comparison	NOUN
dpc-5918	206	3	were	be	AUX
dpc-5918	206	4	made	make	VERB
dpc-5918	206	5	using	use	VERB
dpc-5918	206	6	one	one	NUM
dpc-5918	206	7	-	-	PUNCT
dpc-5918	206	8	way	way	NOUN
dpc-5918	206	9	anova	anova	X
dpc-5918	206	10	(	(	PUNCT
dpc-5918	206	11	tukey	tukey	PROPN
dpc-5918	206	12	’s	’s	PART
dpc-5918	206	13	post	post	X
dpc-5918	206	14	hoc	hoc	X
dpc-5918	206	15	test	test	NOUN
dpc-5918	206	16	)	)	PUNCT
dpc-5918	206	17	.	.	PUNCT
dpc-5918	207	1	*	*	PUNCT
dpc-5918	208	1	*	*	PUNCT
dpc-5918	208	2	*	*	PUNCT
dpc-5918	208	3	*	*	PUNCT
dpc-5918	208	4	p<0.0001	p<0.0001	NOUN
dpc-5918	208	5	.	.	PUNCT
dpc-5918	209	1	flow	flow	NOUN
dpc-5918	209	2	cytometry	cytometry	NOUN
dpc-5918	209	3	.	.	PUNCT
dpc-5918	210	1	while	while	SCONJ
dpc-5918	210	2	no	no	DET
dpc-5918	210	3	statistically	statistically	ADV
dpc-5918	210	4	significant	significant	ADJ
dpc-5918	210	5	change	change	NOUN
dpc-5918	210	6	was	be	AUX
dpc-5918	210	7	observed	observe	VERB
dpc-5918	210	8	in	in	ADP
dpc-5918	210	9	the	the	DET
dpc-5918	210	10	number	number	NOUN
dpc-5918	210	11	of	of	ADP
dpc-5918	210	12	cells	cell	NOUN
dpc-5918	210	13	in	in	ADP
dpc-5918	210	14	the	the	DET
dpc-5918	210	15	g1	g1	NOUN
dpc-5918	210	16	and	and	CCONJ
dpc-5918	210	17	s	s	NOUN
dpc-5918	210	18	phases	phase	NOUN
dpc-5918	210	19	,	,	PUNCT
dpc-5918	210	20	a	a	DET
dpc-5918	210	21	decrease	decrease	NOUN
dpc-5918	210	22	in	in	ADP
dpc-5918	210	23	the	the	DET
dpc-5918	210	24	g2	g2	PROPN
dpc-5918	210	25	phase	phase	NOUN
dpc-5918	210	26	population	population	NOUN
dpc-5918	210	27	and	and	CCONJ
dpc-5918	210	28	a	a	DET
dpc-5918	210	29	significant	significant	ADJ
dpc-5918	210	30	increase	increase	NOUN
dpc-5918	210	31	in	in	ADP
dpc-5918	210	32	the	the	DET
dpc-5918	210	33	sub	sub	ADJ
dpc-5918	210	34	-	-	ADJ
dpc-5918	210	35	g1	g1	ADJ
dpc-5918	210	36	phase	phase	NOUN
dpc-5918	210	37	cells	cell	NOUN
dpc-5918	210	38	were	be	AUX
dpc-5918	210	39	detected	detect	VERB
dpc-5918	210	40	(	(	PUNCT
dpc-5918	210	41	figure	figure	NOUN
dpc-5918	210	42	3a	3a	NUM
dpc-5918	210	43	)	)	PUNCT
dpc-5918	210	44	.	.	PUNCT
dpc-5918	211	1	these	these	DET
dpc-5918	211	2	results	result	NOUN
dpc-5918	211	3	suggest	suggest	VERB
dpc-5918	211	4	that	that	SCONJ
dpc-5918	211	5	grwd1	grwd1	PROPN
dpc-5918	211	6	knockdown	knockdown	NOUN
dpc-5918	211	7	drives	drive	VERB
dpc-5918	211	8	melanoma	melanoma	NOUN
dpc-5918	211	9	cells	cell	NOUN
dpc-5918	211	10	toward	toward	ADP
dpc-5918	211	11	apoptosis	apoptosis	NOUN
dpc-5918	211	12	.	.	PUNCT
dpc-5918	212	1	this	this	DET
dpc-5918	212	2	finding	finding	NOUN
dpc-5918	212	3	was	be	AUX
dpc-5918	212	4	further	far	ADV
dpc-5918	212	5	supported	support	VERB
dpc-5918	212	6	by	by	ADP
dpc-5918	212	7	both	both	DET
dpc-5918	212	8	annexin	annexin	NOUN
dpc-5918	212	9	v	v	NOUN
dpc-5918	212	10	-	-	PUNCT
dpc-5918	212	11	pi	pi	NOUN
dpc-5918	212	12	staining	stain	VERB
dpc-5918	212	13	and	and	CCONJ
dpc-5918	212	14	flow	flow	VERB
dpc-5918	212	15	cytometric	cytometric	ADJ
dpc-5918	212	16	detection	detection	NOUN
dpc-5918	212	17	of	of	ADP
dpc-5918	212	18	cleaved	cleaved	ADJ
dpc-5918	212	19	caspase-3	caspase-3	NUM
dpc-5918	212	20	levels	level	NOUN
dpc-5918	212	21	.	.	PUNCT
dpc-5918	213	1	in	in	ADP
dpc-5918	213	2	annexin	annexin	NOUN
dpc-5918	213	3	v	v	ADP
dpc-5918	213	4	-	-	PUNCT
dpc-5918	213	5	pi	pi	NOUN
dpc-5918	213	6	staining	staining	NOUN
dpc-5918	213	7	,	,	PUNCT
dpc-5918	213	8	the	the	DET
dpc-5918	213	9	apoptotic	apoptotic	ADJ
dpc-5918	213	10	cell	cell	NOUN
dpc-5918	213	11	population	population	NOUN
dpc-5918	213	12	increased	increase	VERB
dpc-5918	213	13	from	from	ADP
dpc-5918	213	14	0.91	0.91	NUM
dpc-5918	213	15	%	%	NOUN
dpc-5918	213	16	to	to	ADP
dpc-5918	213	17	7.82	7.82	NUM
dpc-5918	213	18	%	%	NOUN
dpc-5918	213	19	in	in	ADP
dpc-5918	213	20	the	the	DET
dpc-5918	213	21	grwd1	grwd1	PROPN
dpc-5918	213	22	sirna	sirna	PROPN
dpc-5918	213	23	-	-	PUNCT
dpc-5918	213	24	treated	treat	VERB
dpc-5918	213	25	group	group	NOUN
dpc-5918	213	26	(	(	PUNCT
dpc-5918	213	27	p<0.001	p<0.001	PROPN
dpc-5918	213	28	)	)	PUNCT
dpc-5918	213	29	(	(	PUNCT
dpc-5918	213	30	figure	figure	NOUN
dpc-5918	213	31	3b	3b	NUM
dpc-5918	213	32	)	)	PUNCT
dpc-5918	213	33	.	.	PUNCT
dpc-5918	214	1	additionally	additionally	ADV
dpc-5918	214	2	,	,	PUNCT
dpc-5918	214	3	the	the	DET
dpc-5918	214	4	percentage	percentage	NOUN
dpc-5918	214	5	of	of	ADP
dpc-5918	214	6	cleaved	cleaved	ADJ
dpc-5918	214	7	caspase-3	caspase-3	PROPN
dpc-5918	214	8	-	-	ADJ
dpc-5918	214	9	positive	positive	ADJ
dpc-5918	214	10	cells	cell	NOUN
dpc-5918	214	11	increased	increase	VERB
dpc-5918	214	12	from	from	ADP
dpc-5918	214	13	0.81	0.81	NUM
dpc-5918	214	14	%	%	NOUN
dpc-5918	214	15	in	in	ADP
dpc-5918	214	16	the	the	DET
dpc-5918	214	17	control	control	PROPN
dpc-5918	214	18	sirna	sirna	PROPN
dpc-5918	214	19	group	group	PROPN
dpc-5918	214	20	original	original	ADJ
dpc-5918	214	21	article	article	NOUN
dpc-5918	214	22	|	|	ADV
dpc-5918	214	23	dermatol	dermatol	ADJ
dpc-5918	214	24	pract	pract	NOUN
dpc-5918	214	25	concept	concept	NOUN
dpc-5918	214	26	.	.	PUNCT
dpc-5918	215	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	215	2	7	7	NUM
dpc-5918	215	3	cells	cell	NOUN
dpc-5918	215	4	,	,	PUNCT
dpc-5918	215	5	suppression	suppression	NOUN
dpc-5918	215	6	of	of	ADP
dpc-5918	215	7	grwd1	grwd1	NOUN
dpc-5918	215	8	expression	expression	NOUN
dpc-5918	215	9	led	lead	VERB
dpc-5918	215	10	to	to	ADP
dpc-5918	215	11	a	a	DET
dpc-5918	215	12	70	70	NUM
dpc-5918	215	13	%	%	NOUN
dpc-5918	215	14	reduction	reduction	NOUN
dpc-5918	215	15	in	in	ADP
dpc-5918	215	16	invasion	invasion	NOUN
dpc-5918	215	17	capacity	capacity	NOUN
dpc-5918	215	18	(	(	PUNCT
dpc-5918	215	19	figure	figure	NOUN
dpc-5918	215	20	4a	4a	NUM
dpc-5918	215	21	)	)	PUNCT
dpc-5918	215	22	.	.	PUNCT
dpc-5918	216	1	our	our	PRON
dpc-5918	216	2	findings	finding	NOUN
dpc-5918	216	3	indicate	indicate	VERB
dpc-5918	216	4	that	that	SCONJ
dpc-5918	216	5	grwd1	grwd1	NOUN
dpc-5918	216	6	regulates	regulate	VERB
dpc-5918	216	7	melanoma	melanoma	NOUN
dpc-5918	216	8	cell	cell	NOUN
dpc-5918	216	9	proliferation	proliferation	NOUN
dpc-5918	216	10	,	,	PUNCT
dpc-5918	216	11	apoptosis	apoptosis	NOUN
dpc-5918	216	12	,	,	PUNCT
dpc-5918	216	13	and	and	CCONJ
dpc-5918	216	14	metastasis	metastasis	NOUN
dpc-5918	216	15	.	.	PUNCT
dpc-5918	217	1	as	as	ADP
dpc-5918	217	2	the	the	DET
dpc-5918	217	3	next	next	ADJ
dpc-5918	217	4	step	step	NOUN
dpc-5918	217	5	,	,	PUNCT
dpc-5918	217	6	we	we	PRON
dpc-5918	217	7	performed	perform	VERB
dpc-5918	217	8	western	western	ADJ
dpc-5918	217	9	blot	blot	NOUN
dpc-5918	217	10	analysis	analysis	NOUN
dpc-5918	217	11	to	to	PART
dpc-5918	217	12	identify	identify	VERB
dpc-5918	217	13	the	the	DET
dpc-5918	217	14	molecular	molecular	ADJ
dpc-5918	217	15	mechanisms	mechanism	NOUN
dpc-5918	217	16	underlying	underlie	VERB
dpc-5918	217	17	these	these	DET
dpc-5918	217	18	effects	effect	NOUN
dpc-5918	217	19	.	.	PUNCT
dpc-5918	218	1	we	we	PRON
dpc-5918	218	2	examined	examine	VERB
dpc-5918	218	3	parp	parp	ADJ
dpc-5918	218	4	cleavage	cleavage	NOUN
dpc-5918	218	5	,	,	PUNCT
dpc-5918	218	6	a	a	DET
dpc-5918	218	7	marker	marker	NOUN
dpc-5918	218	8	of	of	ADP
dpc-5918	218	9	apoptosis	apoptosis	NOUN
dpc-5918	218	10	,	,	PUNCT
dpc-5918	218	11	and	and	CCONJ
dpc-5918	218	12	bcl-2	bcl-2	NOUN
dpc-5918	218	13	,	,	PUNCT
dpc-5918	218	14	a	a	DET
dpc-5918	218	15	key	key	ADJ
dpc-5918	218	16	regulator	regulator	NOUN
dpc-5918	218	17	of	of	ADP
dpc-5918	218	18	apoptosis	apoptosis	NOUN
dpc-5918	218	19	that	that	PRON
dpc-5918	218	20	is	be	AUX
dpc-5918	218	21	overexpressed	overexpresse	VERB
dpc-5918	218	22	in	in	ADP
dpc-5918	218	23	more	more	ADJ
dpc-5918	218	24	than	than	ADP
dpc-5918	218	25	half	half	NOUN
dpc-5918	218	26	of	of	ADP
dpc-5918	218	27	all	all	DET
dpc-5918	218	28	cancers	cancer	NOUN
dpc-5918	218	29	.	.	PUNCT
dpc-5918	219	1	suppression	suppression	NOUN
dpc-5918	219	2	of	of	ADP
dpc-5918	219	3	grwd1	grwd1	NOUN
dpc-5918	219	4	expression	expression	NOUN
dpc-5918	219	5	resulted	result	VERB
dpc-5918	219	6	in	in	ADP
dpc-5918	219	7	an	an	DET
dpc-5918	219	8	increase	increase	NOUN
dpc-5918	219	9	in	in	ADP
dpc-5918	219	10	parp	parp	ADJ
dpc-5918	219	11	cleavage	cleavage	NOUN
dpc-5918	219	12	and	and	CCONJ
dpc-5918	219	13	a	a	DET
dpc-5918	219	14	decrease	decrease	NOUN
dpc-5918	219	15	in	in	ADP
dpc-5918	219	16	bcl-2	bcl-2	NOUN
dpc-5918	219	17	expression	expression	NOUN
dpc-5918	219	18	(	(	PUNCT
dpc-5918	219	19	figure	figure	NOUN
dpc-5918	219	20	4b	4b	PROPN
dpc-5918	219	21	)	)	PUNCT
dpc-5918	219	22	.	.	PUNCT
dpc-5918	220	1	additionally	additionally	ADV
dpc-5918	220	2	,	,	PUNCT
dpc-5918	220	3	we	we	PRON
dpc-5918	220	4	investigated	investigate	VERB
dpc-5918	220	5	the	the	DET
dpc-5918	220	6	expression	expression	NOUN
dpc-5918	220	7	of	of	ADP
dpc-5918	220	8	src	src	PROPN
dpc-5918	220	9	kinase	kinase	PROPN
dpc-5918	220	10	,	,	PUNCT
dpc-5918	220	11	a	a	DET
dpc-5918	220	12	key	key	ADJ
dpc-5918	220	13	regulator	regulator	NOUN
dpc-5918	220	14	of	of	ADP
dpc-5918	220	15	invasion	invasion	NOUN
dpc-5918	220	16	,	,	PUNCT
dpc-5918	220	17	and	and	CCONJ
dpc-5918	220	18	found	find	VERB
dpc-5918	220	19	that	that	SCONJ
dpc-5918	220	20	its	its	PRON
dpc-5918	220	21	expression	expression	NOUN
dpc-5918	220	22	was	be	AUX
dpc-5918	220	23	reduced	reduce	VERB
dpc-5918	220	24	following	follow	VERB
dpc-5918	220	25	grwd1	grwd1	NOUN
dpc-5918	220	26	knockdown	knockdown	NOUN
dpc-5918	220	27	(	(	PUNCT
dpc-5918	220	28	figure	figure	NOUN
dpc-5918	220	29	4c	4c	NOUN
dpc-5918	220	30	)	)	PUNCT
dpc-5918	220	31	.	.	PUNCT
dpc-5918	221	1	the	the	DET
dpc-5918	221	2	relationship	relationship	NOUN
dpc-5918	221	3	between	between	ADP
dpc-5918	221	4	mdm2	mdm2	PROPN
dpc-5918	221	5	and	and	CCONJ
dpc-5918	221	6	p53	p53	NOUN
dpc-5918	221	7	proteins	protein	NOUN
dpc-5918	221	8	is	be	AUX
dpc-5918	221	9	well	well	ADV
dpc-5918	221	10	known	know	VERB
dpc-5918	221	11	,	,	PUNCT
dpc-5918	221	12	and	and	CCONJ
dpc-5918	221	13	previous	previous	ADJ
dpc-5918	221	14	studies	study	NOUN
dpc-5918	221	15	have	have	AUX
dpc-5918	221	16	reported	report	VERB
dpc-5918	221	17	that	that	SCONJ
dpc-5918	221	18	grwd1	grwd1	PROPN
dpc-5918	221	19	competes	compete	VERB
dpc-5918	221	20	with	with	ADP
dpc-5918	221	21	rpl11	rpl11	NOUN
dpc-5918	221	22	to	to	PART
dpc-5918	221	23	inhibit	inhibit	VERB
dpc-5918	221	24	mdm2	mdm2	PROPN
dpc-5918	221	25	’s	’s	PART
dpc-5918	221	26	ability	ability	NOUN
dpc-5918	221	27	to	to	PART
dpc-5918	221	28	stabilize	stabilize	VERB
dpc-5918	221	29	p53	p53	NOUN
dpc-5918	221	30	[	[	X
dpc-5918	221	31	8	8	NUM
dpc-5918	221	32	]	]	PUNCT
dpc-5918	221	33	.	.	PUNCT
dpc-5918	222	1	however	however	ADV
dpc-5918	222	2	,	,	PUNCT
dpc-5918	222	3	in	in	ADP
dpc-5918	222	4	our	our	PRON
dpc-5918	222	5	study	study	NOUN
dpc-5918	222	6	,	,	PUNCT
dpc-5918	222	7	we	we	PRON
dpc-5918	222	8	demonstrate	demonstrate	VERB
dpc-5918	222	9	that	that	SCONJ
dpc-5918	222	10	grwd1	grwd1	NOUN
dpc-5918	222	11	positively	positively	ADV
dpc-5918	222	12	regulates	regulate	VERB
dpc-5918	222	13	mdm2	mdm2	NOUN
dpc-5918	222	14	expression	expression	NOUN
dpc-5918	222	15	in	in	ADP
dpc-5918	222	16	melanoma	melanoma	NOUN
dpc-5918	222	17	cells	cell	NOUN
dpc-5918	222	18	.	.	PUNCT
dpc-5918	223	1	when	when	SCONJ
dpc-5918	223	2	grwd1	grwd1	NOUN
dpc-5918	223	3	expression	expression	NOUN
dpc-5918	223	4	was	be	AUX
dpc-5918	223	5	suppressed	suppress	VERB
dpc-5918	223	6	via	via	ADP
dpc-5918	223	7	rna	rna	NOUN
dpc-5918	223	8	interference	interference	NOUN
dpc-5918	223	9	(	(	PUNCT
dpc-5918	223	10	rnai	rnai	PROPN
dpc-5918	223	11	)	)	PUNCT
dpc-5918	223	12	,	,	PUNCT
dpc-5918	223	13	mdm2	mdm2	NOUN
dpc-5918	223	14	expression	expression	NOUN
dpc-5918	223	15	decreased	decrease	VERB
dpc-5918	223	16	in	in	ADP
dpc-5918	223	17	parallel	parallel	NOUN
dpc-5918	223	18	,	,	PUNCT
dpc-5918	223	19	and	and	CCONJ
dpc-5918	223	20	as	as	SCONJ
dpc-5918	223	21	expected	expect	VERB
dpc-5918	223	22	,	,	PUNCT
dpc-5918	223	23	p53	p53	NOUN
dpc-5918	223	24	expression	expression	NOUN
dpc-5918	223	25	increased	increase	VERB
dpc-5918	223	26	(	(	PUNCT
dpc-5918	223	27	figure	figure	NOUN
dpc-5918	223	28	4c	4c	NOUN
dpc-5918	223	29	)	)	PUNCT
dpc-5918	223	30	.	.	PUNCT
dpc-5918	224	1	furthermore	furthermore	ADV
dpc-5918	224	2	,	,	PUNCT
dpc-5918	224	3	we	we	PRON
dpc-5918	224	4	analyzed	analyze	VERB
dpc-5918	224	5	changes	change	NOUN
dpc-5918	224	6	in	in	ADP
dpc-5918	224	7	nf	nf	ADJ
dpc-5918	224	8	-	-	PUNCT
dpc-5918	224	9	κb	κb	NOUN
dpc-5918	224	10	expression	expression	NOUN
dpc-5918	224	11	,	,	PUNCT
dpc-5918	224	12	a	a	DET
dpc-5918	224	13	transcription	transcription	NOUN
dpc-5918	224	14	factor	factor	NOUN
dpc-5918	224	15	known	know	VERB
dpc-5918	224	16	to	to	PART
dpc-5918	224	17	regulate	regulate	VERB
dpc-5918	224	18	the	the	DET
dpc-5918	224	19	expression	expression	NOUN
dpc-5918	224	20	of	of	ADP
dpc-5918	224	21	src	src	NOUN
dpc-5918	224	22	,	,	PUNCT
dpc-5918	224	23	bcl-2	bcl-2	NOUN
dpc-5918	224	24	,	,	PUNCT
dpc-5918	224	25	and	and	CCONJ
dpc-5918	224	26	mdm2	mdm2	NOUN
dpc-5918	224	27	proteins	protein	NOUN
dpc-5918	224	28	.	.	PUNCT
dpc-5918	225	1	we	we	PRON
dpc-5918	225	2	show	show	VERB
dpc-5918	225	3	for	for	ADP
dpc-5918	225	4	the	the	DET
dpc-5918	225	5	first	first	ADJ
dpc-5918	225	6	time	time	NOUN
dpc-5918	225	7	that	that	PRON
dpc-5918	225	8	grwd1	grwd1	PROPN
dpc-5918	225	9	knockdown	knockdown	NOUN
dpc-5918	225	10	suppresses	suppress	VERB
dpc-5918	225	11	nf	nf	ADJ
dpc-5918	225	12	-	-	PUNCT
dpc-5918	225	13	κb	κb	NOUN
dpc-5918	225	14	expression	expression	NOUN
dpc-5918	225	15	(	(	PUNCT
dpc-5918	225	16	figure	figure	NOUN
dpc-5918	225	17	4c	4c	NOUN
dpc-5918	225	18	)	)	PUNCT
dpc-5918	225	19	.	.	PUNCT
dpc-5918	226	1	to	to	PART
dpc-5918	226	2	determine	determine	VERB
dpc-5918	226	3	whether	whether	SCONJ
dpc-5918	226	4	the	the	DET
dpc-5918	226	5	effects	effect	NOUN
dpc-5918	226	6	of	of	ADP
dpc-5918	226	7	grwd1	grwd1	NOUN
dpc-5918	226	8	to	to	ADP
dpc-5918	226	9	17.33	17.33	NUM
dpc-5918	226	10	%	%	NOUN
dpc-5918	226	11	in	in	ADP
dpc-5918	226	12	the	the	DET
dpc-5918	226	13	grwd1	grwd1	PROPN
dpc-5918	226	14	sirna	sirna	PROPN
dpc-5918	226	15	group	group	NOUN
dpc-5918	226	16	(	(	PUNCT
dpc-5918	226	17	p<0.0001	p<0.0001	NOUN
dpc-5918	226	18	)	)	PUNCT
dpc-5918	226	19	(	(	PUNCT
dpc-5918	226	20	figure	figure	VERB
dpc-5918	226	21	3c	3c	NUM
dpc-5918	226	22	)	)	PUNCT
dpc-5918	226	23	.	.	PUNCT
dpc-5918	227	1	these	these	DET
dpc-5918	227	2	findings	finding	NOUN
dpc-5918	227	3	indicate	indicate	VERB
dpc-5918	227	4	that	that	SCONJ
dpc-5918	227	5	grwd1	grwd1	NOUN
dpc-5918	227	6	plays	play	VERB
dpc-5918	227	7	a	a	DET
dpc-5918	227	8	critical	critical	ADJ
dpc-5918	227	9	role	role	NOUN
dpc-5918	227	10	in	in	ADP
dpc-5918	227	11	the	the	DET
dpc-5918	227	12	survival	survival	NOUN
dpc-5918	227	13	of	of	ADP
dpc-5918	227	14	melanoma	melanoma	NOUN
dpc-5918	227	15	cells	cell	NOUN
dpc-5918	227	16	.	.	PUNCT
dpc-5918	228	1	although	although	SCONJ
dpc-5918	228	2	these	these	DET
dpc-5918	228	3	results	result	NOUN
dpc-5918	228	4	show	show	VERB
dpc-5918	228	5	that	that	SCONJ
dpc-5918	228	6	suppression	suppression	NOUN
dpc-5918	228	7	of	of	ADP
dpc-5918	228	8	grwd1	grwd1	NOUN
dpc-5918	228	9	in	in	ADP
dpc-5918	228	10	vitro	vitro	X
dpc-5918	228	11	stimulated	stimulate	VERB
dpc-5918	228	12	cell	cell	NOUN
dpc-5918	228	13	death	death	NOUN
dpc-5918	228	14	,	,	PUNCT
dpc-5918	228	15	no	no	DET
dpc-5918	228	16	significant	significant	ADJ
dpc-5918	228	17	difference	difference	NOUN
dpc-5918	228	18	was	be	AUX
dpc-5918	228	19	found	find	VERB
dpc-5918	228	20	in	in	ADP
dpc-5918	228	21	the	the	DET
dpc-5918	228	22	ihc	ihc	PROPN
dpc-5918	228	23	analyses	analysis	NOUN
dpc-5918	228	24	we	we	PRON
dpc-5918	228	25	performed	perform	VERB
dpc-5918	228	26	on	on	ADP
dpc-5918	228	27	pathology	pathology	NOUN
dpc-5918	228	28	samples	sample	NOUN
dpc-5918	228	29	taken	take	VERB
dpc-5918	228	30	from	from	ADP
dpc-5918	228	31	patients	patient	NOUN
dpc-5918	228	32	(	(	PUNCT
dpc-5918	228	33	figures	figure	NOUN
dpc-5918	228	34	s1	s1	NOUN
dpc-5918	228	35	and	and	CCONJ
dpc-5918	228	36	s2	s2	PROPN
dpc-5918	228	37	)	)	PUNCT
dpc-5918	228	38	.	.	PUNCT
dpc-5918	229	1	grwd1	grwd1	PROPN
dpc-5918	229	2	regulates	regulate	VERB
dpc-5918	229	3	cell	cell	NOUN
dpc-5918	229	4	migration	migration	NOUN
dpc-5918	229	5	in	in	ADP
dpc-5918	229	6	melanoma	melanoma	NOUN
dpc-5918	229	7	cells	cell	NOUN
dpc-5918	229	8	a	a	DET
dpc-5918	229	9	study	study	NOUN
dpc-5918	229	10	on	on	ADP
dpc-5918	229	11	non	non	ADJ
dpc-5918	229	12	-	-	ADJ
dpc-5918	229	13	small	small	ADJ
dpc-5918	229	14	cell	cell	NOUN
dpc-5918	229	15	lung	lung	NOUN
dpc-5918	229	16	cancer	cancer	NOUN
dpc-5918	229	17	reported	report	VERB
dpc-5918	229	18	that	that	SCONJ
dpc-5918	229	19	grwd1	grwd1	NOUN
dpc-5918	229	20	expression	expression	NOUN
dpc-5918	229	21	enhances	enhance	VERB
dpc-5918	229	22	the	the	DET
dpc-5918	229	23	metastatic	metastatic	ADJ
dpc-5918	229	24	potential	potential	NOUN
dpc-5918	229	25	of	of	ADP
dpc-5918	229	26	cells	cell	NOUN
dpc-5918	229	27	[	[	X
dpc-5918	229	28	13	13	NUM
dpc-5918	229	29	]	]	PUNCT
dpc-5918	229	30	.	.	PUNCT
dpc-5918	230	1	another	another	DET
dpc-5918	230	2	study	study	NOUN
dpc-5918	230	3	on	on	ADP
dpc-5918	230	4	triple	triple	ADJ
dpc-5918	230	5	-	-	PUNCT
dpc-5918	230	6	negative	negative	ADJ
dpc-5918	230	7	breast	breast	NOUN
dpc-5918	230	8	cancer	cancer	NOUN
dpc-5918	230	9	demonstrated	demonstrate	VERB
dpc-5918	230	10	that	that	SCONJ
dpc-5918	230	11	suppression	suppression	NOUN
dpc-5918	230	12	of	of	ADP
dpc-5918	230	13	grwd1	grwd1	NOUN
dpc-5918	230	14	expression	expression	NOUN
dpc-5918	230	15	increases	increase	NOUN
dpc-5918	230	16	apoptosis	apoptosis	ADJ
dpc-5918	230	17	while	while	SCONJ
dpc-5918	230	18	reducing	reduce	VERB
dpc-5918	230	19	cell	cell	NOUN
dpc-5918	230	20	migration	migration	NOUN
dpc-5918	230	21	and	and	CCONJ
dpc-5918	230	22	invasion	invasion	NOUN
dpc-5918	230	23	[	[	X
dpc-5918	230	24	14	14	NUM
dpc-5918	230	25	]	]	PUNCT
dpc-5918	230	26	.	.	PUNCT
dpc-5918	231	1	grwd1	grwd1	NOUN
dpc-5918	231	2	overexpression	overexpression	NOUN
dpc-5918	231	3	has	have	AUX
dpc-5918	231	4	been	be	AUX
dpc-5918	231	5	shown	show	VERB
dpc-5918	231	6	to	to	PART
dpc-5918	231	7	be	be	AUX
dpc-5918	231	8	associated	associate	VERB
dpc-5918	231	9	with	with	ADP
dpc-5918	231	10	lymph	lymph	NOUN
dpc-5918	231	11	node	node	ADJ
dpc-5918	231	12	metastasis	metastasis	NOUN
dpc-5918	231	13	in	in	ADP
dpc-5918	231	14	colorectal	colorectal	ADJ
dpc-5918	231	15	carcinoma	carcinoma	NOUN
dpc-5918	231	16	.	.	PUNCT
dpc-5918	232	1	suppression	suppression	NOUN
dpc-5918	232	2	of	of	ADP
dpc-5918	232	3	grwd1	grwd1	NOUN
dpc-5918	232	4	significantly	significantly	ADV
dpc-5918	232	5	reduced	reduce	VERB
dpc-5918	232	6	the	the	DET
dpc-5918	232	7	migration	migration	NOUN
dpc-5918	232	8	and	and	CCONJ
dpc-5918	232	9	invasion	invasion	NOUN
dpc-5918	232	10	abilities	ability	NOUN
dpc-5918	232	11	of	of	ADP
dpc-5918	232	12	colorectal	colorectal	ADJ
dpc-5918	232	13	cancer	cancer	NOUN
dpc-5918	232	14	cells	cell	NOUN
dpc-5918	232	15	in	in	ADP
dpc-5918	232	16	wound	wound	NOUN
dpc-5918	232	17	healing	healing	NOUN
dpc-5918	232	18	and	and	CCONJ
dpc-5918	232	19	transwell	transwell	NOUN
dpc-5918	232	20	assays	assay	NOUN
dpc-5918	233	1	[	[	X
dpc-5918	233	2	16	16	NUM
dpc-5918	233	3	]	]	PUNCT
dpc-5918	233	4	.	.	PUNCT
dpc-5918	234	1	a	a	DET
dpc-5918	234	2	similar	similar	ADJ
dpc-5918	234	3	study	study	NOUN
dpc-5918	234	4	on	on	ADP
dpc-5918	234	5	gastric	gastric	ADJ
dpc-5918	234	6	cancer	cancer	NOUN
dpc-5918	234	7	also	also	ADV
dpc-5918	234	8	obtained	obtain	VERB
dpc-5918	234	9	comparable	comparable	ADJ
dpc-5918	234	10	results	result	NOUN
dpc-5918	234	11	,	,	PUNCT
dpc-5918	234	12	demonstrating	demonstrate	VERB
dpc-5918	234	13	that	that	SCONJ
dpc-5918	234	14	grwd1	grwd1	NOUN
dpc-5918	234	15	suppression	suppression	NOUN
dpc-5918	234	16	significantly	significantly	ADV
dpc-5918	234	17	reduces	reduce	VERB
dpc-5918	234	18	cell	cell	NOUN
dpc-5918	234	19	migration	migration	NOUN
dpc-5918	234	20	and	and	CCONJ
dpc-5918	234	21	invasion	invasion	NOUN
dpc-5918	234	22	[	[	X
dpc-5918	234	23	15	15	NUM
dpc-5918	234	24	]	]	PUNCT
dpc-5918	234	25	.	.	PUNCT
dpc-5918	235	1	grwd1	grwd1	NOUN
dpc-5918	235	2	has	have	AUX
dpc-5918	235	3	been	be	AUX
dpc-5918	235	4	reported	report	VERB
dpc-5918	235	5	to	to	PART
dpc-5918	235	6	enhance	enhance	VERB
dpc-5918	235	7	the	the	DET
dpc-5918	235	8	invasive	invasive	ADJ
dpc-5918	235	9	ability	ability	NOUN
dpc-5918	235	10	of	of	ADP
dpc-5918	235	11	cancer	cancer	NOUN
dpc-5918	235	12	cells	cell	NOUN
dpc-5918	235	13	in	in	ADP
dpc-5918	235	14	all	all	DET
dpc-5918	235	15	these	these	DET
dpc-5918	235	16	cancer	cancer	NOUN
dpc-5918	235	17	types	type	NOUN
dpc-5918	235	18	.	.	PUNCT
dpc-5918	236	1	to	to	PART
dpc-5918	236	2	evaluate	evaluate	VERB
dpc-5918	236	3	the	the	DET
dpc-5918	236	4	invasion	invasion	NOUN
dpc-5918	236	5	capacity	capacity	NOUN
dpc-5918	236	6	of	of	ADP
dpc-5918	236	7	melanoma	melanoma	NOUN
dpc-5918	236	8	cells	cell	NOUN
dpc-5918	236	9	in	in	ADP
dpc-5918	236	10	vitro	vitro	X
dpc-5918	236	11	,	,	PUNCT
dpc-5918	236	12	we	we	PRON
dpc-5918	236	13	used	use	VERB
dpc-5918	236	14	matrigel	matrigel	NOUN
dpc-5918	236	15	-	-	PUNCT
dpc-5918	236	16	coated	coat	VERB
dpc-5918	236	17	boyden	boyden	PROPN
dpc-5918	236	18	chambers	chamber	NOUN
dpc-5918	236	19	.	.	PUNCT
dpc-5918	237	1	in	in	ADP
dpc-5918	237	2	a2058	a2058	NUM
dpc-5918	237	3	melanoma	melanoma	NOUN
dpc-5918	237	4	figure	figure	NOUN
dpc-5918	237	5	4	4	NUM
dpc-5918	237	6	.	.	PUNCT
dpc-5918	237	7	grwd1	grwd1	NOUN
dpc-5918	237	8	knockdown	knockdown	NOUN
dpc-5918	237	9	suppresses	suppress	VERB
dpc-5918	237	10	invasion	invasion	NOUN
dpc-5918	237	11	and	and	CCONJ
dpc-5918	237	12	oncogenic	oncogenic	NOUN
dpc-5918	237	13	signaling	signal	VERB
dpc-5918	237	14	in	in	ADP
dpc-5918	237	15	melanoma	melanoma	NOUN
dpc-5918	237	16	cells	cell	NOUN
dpc-5918	237	17	.	.	PUNCT
dpc-5918	238	1	(	(	PUNCT
dpc-5918	238	2	a	a	X
dpc-5918	238	3	)	)	PUNCT
dpc-5918	238	4	matrigel	matrigel	NOUN
dpc-5918	238	5	invasion	invasion	NOUN
dpc-5918	238	6	assay	assay	NOUN
dpc-5918	238	7	shows	show	NOUN
dpc-5918	238	8	significantly	significantly	ADV
dpc-5918	238	9	reduced	reduce	VERB
dpc-5918	238	10	invasion	invasion	NOUN
dpc-5918	238	11	capacity	capacity	NOUN
dpc-5918	238	12	in	in	ADP
dpc-5918	238	13	grwd1	grwd1	PROPN
dpc-5918	238	14	sirna	sirna	PROPN
dpc-5918	238	15	-	-	PUNCT
dpc-5918	238	16	treated	treat	VERB
dpc-5918	238	17	melanoma	melanoma	NOUN
dpc-5918	238	18	cells	cell	NOUN
dpc-5918	238	19	(	(	PUNCT
dpc-5918	238	20	*	*	PUNCT
dpc-5918	238	21	*	*	PUNCT
dpc-5918	238	22	*	*	PUNCT
dpc-5918	238	23	*	*	PUNCT
dpc-5918	238	24	p<0.001	p<0.001	ADJ
dpc-5918	238	25	)	)	PUNCT
dpc-5918	238	26	.	.	PUNCT
dpc-5918	239	1	(	(	PUNCT
dpc-5918	239	2	b	b	X
dpc-5918	239	3	)	)	PUNCT
dpc-5918	239	4	western	western	ADJ
dpc-5918	239	5	blot	blot	NOUN
dpc-5918	239	6	analysis	analysis	NOUN
dpc-5918	239	7	shows	show	VERB
dpc-5918	239	8	reduced	reduce	VERB
dpc-5918	239	9	bcl-2	bcl-2	NOUN
dpc-5918	239	10	expression	expression	NOUN
dpc-5918	239	11	and	and	CCONJ
dpc-5918	239	12	increased	increase	VERB
dpc-5918	239	13	cleaved	cleaved	ADJ
dpc-5918	239	14	parp	parp	ADJ
dpc-5918	239	15	levels	level	NOUN
dpc-5918	239	16	in	in	ADP
dpc-5918	239	17	grwd1	grwd1	NOUN
dpc-5918	239	18	knockdown	knockdown	NOUN
dpc-5918	239	19	cells	cell	NOUN
dpc-5918	239	20	,	,	PUNCT
dpc-5918	239	21	indicating	indicate	VERB
dpc-5918	239	22	apoptosis	apoptosis	NOUN
dpc-5918	239	23	.	.	PUNCT
dpc-5918	240	1	(	(	PUNCT
dpc-5918	240	2	c	c	X
dpc-5918	240	3	)	)	PUNCT
dpc-5918	240	4	western	western	ADJ
dpc-5918	240	5	blot	blot	NOUN
dpc-5918	240	6	analysis	analysis	NOUN
dpc-5918	240	7	of	of	ADP
dpc-5918	240	8	key	key	ADJ
dpc-5918	240	9	oncogenic	oncogenic	ADJ
dpc-5918	240	10	signaling	signal	VERB
dpc-5918	240	11	proteins	protein	NOUN
dpc-5918	240	12	.	.	PUNCT
dpc-5918	241	1	grwd1	grwd1	NOUN
dpc-5918	241	2	knockdown	knockdown	NOUN
dpc-5918	241	3	leads	lead	VERB
dpc-5918	241	4	to	to	PART
dpc-5918	241	5	decreased	decrease	VERB
dpc-5918	241	6	nf	nf	PROPN
dpc-5918	241	7	-	-	PUNCT
dpc-5918	241	8	κb	κb	ADJ
dpc-5918	241	9	,	,	PUNCT
dpc-5918	241	10	src	src	NOUN
dpc-5918	241	11	,	,	PUNCT
dpc-5918	241	12	and	and	CCONJ
dpc-5918	241	13	mdm2	mdm2	NOUN
dpc-5918	241	14	expression	expression	NOUN
dpc-5918	241	15	while	while	SCONJ
dpc-5918	241	16	increasing	increase	VERB
dpc-5918	241	17	p53	p53	NOUN
dpc-5918	241	18	levels	level	NOUN
dpc-5918	241	19	.	.	PUNCT
dpc-5918	242	1	(	(	PUNCT
dpc-5918	242	2	d	d	X
dpc-5918	242	3	)	)	PUNCT
dpc-5918	242	4	validation	validation	NOUN
dpc-5918	242	5	of	of	ADP
dpc-5918	242	6	grwd1	grwd1	NOUN
dpc-5918	242	7	knockdown	knockdown	NOUN
dpc-5918	242	8	effects	effect	NOUN
dpc-5918	242	9	in	in	ADP
dpc-5918	242	10	a2780	a2780	ADJ
dpc-5918	242	11	ovarian	ovarian	ADJ
dpc-5918	242	12	cancer	cancer	NOUN
dpc-5918	242	13	cells	cell	NOUN
dpc-5918	242	14	.	.	PUNCT
dpc-5918	243	1	cell	cell	NOUN
dpc-5918	243	2	viability	viability	NOUN
dpc-5918	243	3	is	be	AUX
dpc-5918	243	4	significantly	significantly	ADV
dpc-5918	243	5	reduced	reduce	VERB
dpc-5918	243	6	after	after	ADP
dpc-5918	243	7	grwd1	grwd1	NOUN
dpc-5918	243	8	knockdown	knockdown	NOUN
dpc-5918	243	9	(	(	PUNCT
dpc-5918	243	10	*	*	NOUN
dpc-5918	243	11	p<0.05	p<0.05	NOUN
dpc-5918	243	12	,	,	PUNCT
dpc-5918	243	13	*	*	PUNCT
dpc-5918	243	14	p<0.01	p<0.01	PROPN
dpc-5918	243	15	)	)	PUNCT
dpc-5918	243	16	.	.	PUNCT
dpc-5918	244	1	flow	flow	NOUN
dpc-5918	244	2	cytometry	cytometry	NOUN
dpc-5918	244	3	and	and	CCONJ
dpc-5918	244	4	western	western	ADJ
dpc-5918	244	5	blot	blot	NOUN
dpc-5918	244	6	data	datum	NOUN
dpc-5918	244	7	represent	represent	VERB
dpc-5918	244	8	mean	mean	NOUN
dpc-5918	244	9	±	±	NUM
dpc-5918	244	10	sd	sd	NOUN
dpc-5918	244	11	from	from	ADP
dpc-5918	244	12	three	three	NUM
dpc-5918	244	13	independent	independent	ADJ
dpc-5918	244	14	experiments	experiment	NOUN
dpc-5918	244	15	.	.	PUNCT
dpc-5918	245	1	statistical	statistical	ADJ
dpc-5918	245	2	comparisons	comparison	NOUN
dpc-5918	245	3	were	be	AUX
dpc-5918	245	4	made	make	VERB
dpc-5918	245	5	using	use	VERB
dpc-5918	245	6	one	one	NUM
dpc-5918	245	7	-	-	PUNCT
dpc-5918	245	8	way	way	NOUN
dpc-5918	245	9	anova	anova	X
dpc-5918	245	10	(	(	PUNCT
dpc-5918	245	11	tukey	tukey	PROPN
dpc-5918	245	12	’s	’s	PART
dpc-5918	245	13	post	post	X
dpc-5918	245	14	hoc	hoc	X
dpc-5918	245	15	test	test	NOUN
dpc-5918	245	16	)	)	PUNCT
dpc-5918	245	17	.	.	PUNCT
dpc-5918	246	1	8	8	NUM
dpc-5918	246	2	original	original	ADJ
dpc-5918	246	3	article	article	NOUN
dpc-5918	246	4	|	|	ADV
dpc-5918	246	5	dermatol	dermatol	ADJ
dpc-5918	246	6	pract	pract	NOUN
dpc-5918	246	7	concept	concept	NOUN
dpc-5918	246	8	.	.	PUNCT
dpc-5918	247	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	247	2	discussion	discussion	NOUN
dpc-5918	247	3	grwd1	grwd1	NOUN
dpc-5918	247	4	is	be	AUX
dpc-5918	247	5	a	a	DET
dpc-5918	247	6	multifunctional	multifunctional	ADJ
dpc-5918	247	7	protein	protein	NOUN
dpc-5918	247	8	that	that	PRON
dpc-5918	247	9	has	have	AUX
dpc-5918	247	10	been	be	AUX
dpc-5918	247	11	implicated	implicate	VERB
dpc-5918	247	12	in	in	ADP
dpc-5918	247	13	various	various	ADJ
dpc-5918	247	14	cellular	cellular	ADJ
dpc-5918	247	15	processes	process	NOUN
dpc-5918	247	16	,	,	PUNCT
dpc-5918	247	17	including	include	VERB
dpc-5918	247	18	ribosome	ribosome	NOUN
dpc-5918	247	19	biogenesis	biogenesis	NOUN
dpc-5918	247	20	,	,	PUNCT
dpc-5918	247	21	dna	dna	NOUN
dpc-5918	247	22	damage	damage	NOUN
dpc-5918	247	23	response	response	NOUN
dpc-5918	247	24	,	,	PUNCT
dpc-5918	247	25	and	and	CCONJ
dpc-5918	247	26	chromatin	chromatin	NOUN
dpc-5918	247	27	remodeling	remodeling	NOUN
dpc-5918	247	28	.	.	PUNCT
dpc-5918	248	1	the	the	DET
dpc-5918	248	2	regulation	regulation	NOUN
dpc-5918	248	3	of	of	ADP
dpc-5918	248	4	protein	protein	NOUN
dpc-5918	248	5	expression	expression	NOUN
dpc-5918	248	6	via	via	ADP
dpc-5918	248	7	the	the	DET
dpc-5918	248	8	suppression	suppression	NOUN
dpc-5918	248	9	of	of	ADP
dpc-5918	248	10	grwd1	grwd1	NOUN
dpc-5918	248	11	gene	gene	NOUN
dpc-5918	248	12	led	lead	VERB
dpc-5918	248	13	to	to	ADP
dpc-5918	248	14	a	a	DET
dpc-5918	248	15	reduction	reduction	NOUN
dpc-5918	248	16	in	in	ADP
dpc-5918	248	17	nf	nf	ADJ
dpc-5918	248	18	-	-	PUNCT
dpc-5918	248	19	κb	κb	NOUN
dpc-5918	248	20	expression	expression	NOUN
dpc-5918	248	21	.	.	PUNCT
dpc-5918	249	1	nf	nf	X
dpc-5918	249	2	-	-	PUNCT
dpc-5918	249	3	κb	κb	NOUN
dpc-5918	249	4	,	,	PUNCT
dpc-5918	249	5	recognized	recognize	VERB
dpc-5918	249	6	as	as	ADP
dpc-5918	249	7	a	a	DET
dpc-5918	249	8	transcription	transcription	NOUN
dpc-5918	249	9	factor	factor	NOUN
dpc-5918	249	10	that	that	PRON
dpc-5918	249	11	orchestrates	orchestrate	VERB
dpc-5918	249	12	various	various	ADJ
dpc-5918	249	13	cellular	cellular	ADJ
dpc-5918	249	14	functions	function	NOUN
dpc-5918	249	15	including	include	VERB
dpc-5918	249	16	immune	immune	ADJ
dpc-5918	249	17	response	response	NOUN
dpc-5918	249	18	,	,	PUNCT
dpc-5918	249	19	inflammation	inflammation	NOUN
dpc-5918	249	20	,	,	PUNCT
dpc-5918	249	21	and	and	CCONJ
dpc-5918	249	22	cell	cell	NOUN
dpc-5918	249	23	viability	viability	NOUN
dpc-5918	249	24	,	,	PUNCT
dpc-5918	249	25	is	be	AUX
dpc-5918	249	26	extensively	extensively	ADV
dpc-5918	249	27	reported	report	VERB
dpc-5918	249	28	in	in	ADP
dpc-5918	249	29	scholarly	scholarly	ADJ
dpc-5918	249	30	literature	literature	NOUN
dpc-5918	249	31	for	for	ADP
dpc-5918	249	32	its	its	PRON
dpc-5918	249	33	role	role	NOUN
dpc-5918	249	34	in	in	ADP
dpc-5918	249	35	modulating	modulate	VERB
dpc-5918	249	36	the	the	DET
dpc-5918	249	37	expression	expression	NOUN
dpc-5918	249	38	of	of	ADP
dpc-5918	249	39	numerous	numerous	ADJ
dpc-5918	249	40	proteins	protein	NOUN
dpc-5918	249	41	such	such	ADJ
dpc-5918	249	42	as	as	ADP
dpc-5918	249	43	bcl-2	bcl-2	NOUN
dpc-5918	249	44	,	,	PUNCT
dpc-5918	249	45	src	src	NOUN
dpc-5918	249	46	,	,	PUNCT
dpc-5918	249	47	and	and	CCONJ
dpc-5918	249	48	mdm2	mdm2	PROPN
dpc-5918	249	49	.	.	PUNCT
dpc-5918	250	1	grwd1	grwd1	PROPN
dpc-5918	250	2	has	have	AUX
dpc-5918	250	3	been	be	AUX
dpc-5918	250	4	previously	previously	ADV
dpc-5918	250	5	shown	show	VERB
dpc-5918	250	6	to	to	PART
dpc-5918	250	7	participate	participate	VERB
dpc-5918	250	8	in	in	ADP
dpc-5918	250	9	both	both	CCONJ
dpc-5918	250	10	ribosome	ribosome	ADJ
dpc-5918	250	11	biogenesis	biogenesis	NOUN
dpc-5918	250	12	and	and	CCONJ
dpc-5918	250	13	chromatin	chromatin	NOUN
dpc-5918	250	14	remodeling	remodeling	NOUN
dpc-5918	250	15	processes	process	NOUN
dpc-5918	250	16	through	through	ADP
dpc-5918	250	17	interactions	interaction	NOUN
dpc-5918	250	18	with	with	ADP
dpc-5918	250	19	rpl11	rpl11	NOUN
dpc-5918	250	20	,	,	PUNCT
dpc-5918	250	21	wdr5	wdr5	NOUN
dpc-5918	250	22	,	,	PUNCT
dpc-5918	250	23	and	and	CCONJ
dpc-5918	250	24	other	other	ADJ
dpc-5918	250	25	regulatory	regulatory	ADJ
dpc-5918	250	26	proteins	protein	NOUN
dpc-5918	250	27	[	[	X
dpc-5918	250	28	13,17,18	13,17,18	NUM
dpc-5918	250	29	]	]	PUNCT
dpc-5918	250	30	.	.	PUNCT
dpc-5918	251	1	in	in	ADP
dpc-5918	251	2	our	our	PRON
dpc-5918	251	3	study	study	NOUN
dpc-5918	251	4	,	,	PUNCT
dpc-5918	251	5	we	we	PRON
dpc-5918	251	6	observed	observe	VERB
dpc-5918	251	7	that	that	SCONJ
dpc-5918	251	8	grwd1	grwd1	PROPN
dpc-5918	251	9	knockdown	knockdown	NOUN
dpc-5918	251	10	led	lead	VERB
dpc-5918	251	11	to	to	ADP
dpc-5918	251	12	a	a	DET
dpc-5918	251	13	reduction	reduction	NOUN
dpc-5918	251	14	in	in	ADP
dpc-5918	251	15	nf	nf	ADJ
dpc-5918	251	16	-	-	PUNCT
dpc-5918	251	17	κb	κb	ADJ
dpc-5918	251	18	protein	protein	NOUN
dpc-5918	251	19	levels	level	NOUN
dpc-5918	251	20	.	.	PUNCT
dpc-5918	252	1	however	however	ADV
dpc-5918	252	2	,	,	PUNCT
dpc-5918	252	3	we	we	PRON
dpc-5918	252	4	did	do	AUX
dpc-5918	252	5	not	not	PART
dpc-5918	252	6	assess	assess	VERB
dpc-5918	252	7	nf	nf	ADJ
dpc-5918	252	8	-	-	PUNCT
dpc-5918	252	9	κb	κb	ADJ
dpc-5918	252	10	mrna	mrna	NOUN
dpc-5918	252	11	expression	expression	NOUN
dpc-5918	252	12	.	.	PUNCT
dpc-5918	253	1	therefore	therefore	ADV
dpc-5918	253	2	,	,	PUNCT
dpc-5918	253	3	while	while	SCONJ
dpc-5918	253	4	our	our	PRON
dpc-5918	253	5	data	datum	NOUN
dpc-5918	253	6	support	support	VERB
dpc-5918	253	7	a	a	DET
dpc-5918	253	8	link	link	NOUN
dpc-5918	253	9	between	between	ADP
dpc-5918	253	10	grwd1	grwd1	NOUN
dpc-5918	253	11	and	and	CCONJ
dpc-5918	253	12	nf	nf	ADJ
dpc-5918	253	13	-	-	PUNCT
dpc-5918	253	14	κb	κb	NOUN
dpc-5918	253	15	activity	activity	NOUN
dpc-5918	253	16	,	,	PUNCT
dpc-5918	253	17	the	the	DET
dpc-5918	253	18	underlying	underlying	ADJ
dpc-5918	253	19	mechanism	mechanism	NOUN
dpc-5918	253	20	remains	remain	VERB
dpc-5918	253	21	unclear	unclear	ADJ
dpc-5918	253	22	.	.	PUNCT
dpc-5918	254	1	based	base	VERB
dpc-5918	254	2	on	on	ADP
dpc-5918	254	3	the	the	DET
dpc-5918	254	4	existing	exist	VERB
dpc-5918	254	5	literature	literature	NOUN
dpc-5918	254	6	,	,	PUNCT
dpc-5918	254	7	we	we	PRON
dpc-5918	254	8	propose	propose	VERB
dpc-5918	254	9	that	that	SCONJ
dpc-5918	254	10	grwd1	grwd1	NOUN
dpc-5918	254	11	may	may	AUX
dpc-5918	254	12	influence	influence	VERB
dpc-5918	254	13	nf	nf	NOUN
dpc-5918	254	14	-	-	PUNCT
dpc-5918	254	15	κb	κb	NOUN
dpc-5918	254	16	at	at	ADP
dpc-5918	254	17	the	the	DET
dpc-5918	254	18	translational	translational	ADJ
dpc-5918	254	19	or	or	CCONJ
dpc-5918	254	20	chromatin	chromatin	NOUN
dpc-5918	254	21	remodeling	remodeling	NOUN
dpc-5918	254	22	level	level	NOUN
dpc-5918	254	23	,	,	PUNCT
dpc-5918	254	24	although	although	SCONJ
dpc-5918	254	25	this	this	PRON
dpc-5918	254	26	remains	remain	VERB
dpc-5918	254	27	speculative	speculative	ADJ
dpc-5918	254	28	and	and	CCONJ
dpc-5918	254	29	was	be	AUX
dpc-5918	254	30	not	not	PART
dpc-5918	254	31	directly	directly	ADV
dpc-5918	254	32	tested	test	VERB
dpc-5918	254	33	in	in	ADP
dpc-5918	254	34	our	our	PRON
dpc-5918	254	35	study	study	NOUN
dpc-5918	254	36	.	.	PUNCT
dpc-5918	255	1	our	our	PRON
dpc-5918	255	2	data	datum	NOUN
dpc-5918	255	3	demonstrate	demonstrate	VERB
dpc-5918	255	4	that	that	SCONJ
dpc-5918	255	5	grwd1	grwd1	NOUN
dpc-5918	255	6	silencing	silence	VERB
dpc-5918	255	7	leads	lead	VERB
dpc-5918	255	8	to	to	ADP
dpc-5918	255	9	a	a	DET
dpc-5918	255	10	suppression	suppression	NOUN
dpc-5918	255	11	of	of	ADP
dpc-5918	255	12	nf	nf	ADJ
dpc-5918	255	13	-	-	PUNCT
dpc-5918	255	14	κb	κb	NOUN
dpc-5918	255	15	expression	expression	NOUN
dpc-5918	255	16	,	,	PUNCT
dpc-5918	255	17	which	which	PRON
dpc-5918	255	18	likely	likely	ADV
dpc-5918	255	19	results	result	VERB
dpc-5918	255	20	in	in	ADP
dpc-5918	255	21	transcriptional	transcriptional	ADJ
dpc-5918	255	22	downregulation	downregulation	NOUN
dpc-5918	255	23	of	of	ADP
dpc-5918	255	24	downstream	downstream	ADJ
dpc-5918	255	25	targets	target	NOUN
dpc-5918	255	26	such	such	ADJ
dpc-5918	255	27	as	as	ADP
dpc-5918	255	28	bcl-2	bcl-2	NOUN
dpc-5918	255	29	,	,	PUNCT
dpc-5918	255	30	src	src	NOUN
dpc-5918	255	31	,	,	PUNCT
dpc-5918	255	32	and	and	CCONJ
dpc-5918	255	33	mdm2	mdm2	PROPN
dpc-5918	255	34	.	.	PUNCT
dpc-5918	256	1	this	this	PRON
dpc-5918	256	2	is	be	AUX
dpc-5918	256	3	supported	support	VERB
dpc-5918	256	4	by	by	ADP
dpc-5918	256	5	the	the	DET
dpc-5918	256	6	observed	observe	VERB
dpc-5918	256	7	decrease	decrease	NOUN
dpc-5918	256	8	in	in	ADP
dpc-5918	256	9	their	their	PRON
dpc-5918	256	10	protein	protein	NOUN
dpc-5918	256	11	levels	level	NOUN
dpc-5918	256	12	(	(	PUNCT
dpc-5918	256	13	figure	figure	NOUN
dpc-5918	256	14	4c	4c	NOUN
dpc-5918	256	15	)	)	PUNCT
dpc-5918	256	16	,	,	PUNCT
dpc-5918	256	17	consistent	consistent	ADJ
dpc-5918	256	18	with	with	ADP
dpc-5918	256	19	nf	nf	ADJ
dpc-5918	256	20	-	-	PUNCT
dpc-5918	256	21	κb	κb	NOUN
dpc-5918	256	22	’s	’s	PART
dpc-5918	256	23	known	know	VERB
dpc-5918	256	24	role	role	NOUN
dpc-5918	256	25	as	as	ADP
dpc-5918	256	26	a	a	DET
dpc-5918	256	27	transcriptional	transcriptional	ADJ
dpc-5918	256	28	activator	activator	NOUN
dpc-5918	256	29	.	.	PUNCT
dpc-5918	257	1	nevertheless	nevertheless	ADV
dpc-5918	257	2	,	,	PUNCT
dpc-5918	257	3	post	post	ADJ
dpc-5918	257	4	-	-	ADJ
dpc-5918	257	5	transcriptional	transcriptional	ADJ
dpc-5918	257	6	regulatory	regulatory	ADJ
dpc-5918	257	7	mechanisms	mechanism	NOUN
dpc-5918	257	8	may	may	AUX
dpc-5918	257	9	also	also	ADV
dpc-5918	257	10	contribute	contribute	VERB
dpc-5918	257	11	to	to	ADP
dpc-5918	257	12	this	this	DET
dpc-5918	257	13	downregulation	downregulation	NOUN
dpc-5918	257	14	,	,	PUNCT
dpc-5918	257	15	as	as	SCONJ
dpc-5918	257	16	grwd1	grwd1	NOUN
dpc-5918	257	17	is	be	AUX
dpc-5918	257	18	known	know	VERB
dpc-5918	257	19	to	to	PART
dpc-5918	257	20	regulate	regulate	VERB
dpc-5918	257	21	ribosome	ribosome	ADJ
dpc-5918	257	22	biogenesis	biogenesis	NOUN
dpc-5918	257	23	and	and	CCONJ
dpc-5918	257	24	mrna	mrna	PROPN
dpc-5918	257	25	translation	translation	NOUN
dpc-5918	257	26	processes	process	NOUN
dpc-5918	257	27	.	.	PUNCT
dpc-5918	258	1	this	this	DET
dpc-5918	258	2	action	action	NOUN
dpc-5918	258	3	is	be	AUX
dpc-5918	258	4	also	also	ADV
dpc-5918	258	5	supported	support	VERB
dpc-5918	258	6	by	by	ADP
dpc-5918	258	7	kayama	kayama	PROPN
dpc-5918	258	8	et	et	PROPN
dpc-5918	258	9	al	al	PROPN
dpc-5918	258	10	.	.	PUNCT
dpc-5918	259	1	[	[	X
dpc-5918	259	2	19	19	NUM
dpc-5918	259	3	]	]	PUNCT
dpc-5918	259	4	,	,	PUNCT
dpc-5918	259	5	who	who	PRON
dpc-5918	259	6	reported	report	VERB
dpc-5918	259	7	that	that	SCONJ
dpc-5918	259	8	elevated	elevated	ADJ
dpc-5918	259	9	expression	expression	NOUN
dpc-5918	259	10	levels	level	NOUN
dpc-5918	259	11	of	of	ADP
dpc-5918	259	12	grwd1	grwd1	NOUN
dpc-5918	259	13	were	be	AUX
dpc-5918	259	14	associated	associate	VERB
dpc-5918	259	15	with	with	ADP
dpc-5918	259	16	skcm	skcm	NOUN
dpc-5918	259	17	as	as	ADV
dpc-5918	259	18	well	well	ADV
dpc-5918	259	19	as	as	ADP
dpc-5918	259	20	with	with	ADP
dpc-5918	259	21	certain	certain	ADJ
dpc-5918	259	22	other	other	ADJ
dpc-5918	259	23	malignancies	malignancy	NOUN
dpc-5918	259	24	with	with	ADP
dpc-5918	259	25	unfavorable	unfavorable	ADJ
dpc-5918	259	26	prognosis	prognosis	NOUN
dpc-5918	259	27	.	.	PUNCT
dpc-5918	260	1	the	the	DET
dpc-5918	260	2	decrease	decrease	NOUN
dpc-5918	260	3	in	in	ADP
dpc-5918	260	4	mdm2	mdm2	NOUN
dpc-5918	260	5	expression	expression	NOUN
dpc-5918	260	6	upon	upon	SCONJ
dpc-5918	260	7	grwd1	grwd1	NOUN
dpc-5918	260	8	knockdown	knockdown	NOUN
dpc-5918	260	9	,	,	PUNCT
dpc-5918	260	10	which	which	PRON
dpc-5918	260	11	results	result	VERB
dpc-5918	260	12	in	in	ADP
dpc-5918	260	13	the	the	DET
dpc-5918	260	14	stabilization	stabilization	NOUN
dpc-5918	260	15	of	of	ADP
dpc-5918	260	16	p53	p53	NOUN
dpc-5918	260	17	,	,	PUNCT
dpc-5918	260	18	emphasizes	emphasize	VERB
dpc-5918	260	19	the	the	DET
dpc-5918	260	20	significance	significance	NOUN
dpc-5918	260	21	of	of	ADP
dpc-5918	260	22	this	this	DET
dpc-5918	260	23	pathway	pathway	NOUN
dpc-5918	260	24	in	in	ADP
dpc-5918	260	25	melanoma	melanoma	NOUN
dpc-5918	260	26	.	.	PUNCT
dpc-5918	261	1	earlier	early	ADJ
dpc-5918	261	2	studies	study	NOUN
dpc-5918	261	3	have	have	AUX
dpc-5918	261	4	indicated	indicate	VERB
dpc-5918	261	5	that	that	SCONJ
dpc-5918	261	6	grwd1	grwd1	NOUN
dpc-5918	261	7	binds	bind	VERB
dpc-5918	261	8	with	with	ADP
dpc-5918	261	9	ribosomal	ribosomal	NOUN
dpc-5918	261	10	proteins	protein	NOUN
dpc-5918	261	11	to	to	PART
dpc-5918	261	12	control	control	VERB
dpc-5918	261	13	translational	translational	ADJ
dpc-5918	261	14	mechanisms	mechanism	NOUN
dpc-5918	261	15	and	and	CCONJ
dpc-5918	261	16	promote	promote	VERB
dpc-5918	261	17	protein	protein	NOUN
dpc-5918	261	18	synthesis	synthesis	NOUN
dpc-5918	261	19	in	in	ADP
dpc-5918	261	20	neoplastic	neoplastic	ADJ
dpc-5918	261	21	cells	cell	NOUN
dpc-5918	261	22	[	[	X
dpc-5918	261	23	13	13	NUM
dpc-5918	261	24	]	]	PUNCT
dpc-5918	261	25	.	.	PUNCT
dpc-5918	262	1	these	these	DET
dpc-5918	262	2	observations	observation	NOUN
dpc-5918	262	3	are	be	AUX
dpc-5918	262	4	a	a	DET
dpc-5918	262	5	direct	direct	ADJ
dpc-5918	262	6	association	association	NOUN
dpc-5918	262	7	between	between	ADP
dpc-5918	262	8	grwd1	grwd1	NOUN
dpc-5918	262	9	and	and	CCONJ
dpc-5918	262	10	tumor	tumor	NOUN
dpc-5918	262	11	growth	growth	NOUN
dpc-5918	262	12	via	via	ADP
dpc-5918	262	13	the	the	DET
dpc-5918	262	14	mdm2	mdm2	PROPN
dpc-5918	262	15	-	-	PUNCT
dpc-5918	262	16	p53	p53	NOUN
dpc-5918	262	17	pathway	pathway	NOUN
dpc-5918	262	18	.	.	PUNCT
dpc-5918	263	1	deng	deng	PROPN
dpc-5918	263	2	et	et	PROPN
dpc-5918	263	3	al	al	PROPN
dpc-5918	263	4	.	.	PROPN
dpc-5918	263	5	's	's	PART
dpc-5918	263	6	research	research	NOUN
dpc-5918	263	7	confirmed	confirm	VERB
dpc-5918	263	8	that	that	SCONJ
dpc-5918	263	9	the	the	DET
dpc-5918	263	10	long	long	ADJ
dpc-5918	263	11	non	non	ADJ
dpc-5918	263	12	-	-	ADJ
dpc-5918	263	13	coding	coding	ADJ
dpc-5918	263	14	rna	rna	NOUN
dpc-5918	263	15	(	(	PUNCT
dpc-5918	263	16	lncrna	lncrna	NOUN
dpc-5918	263	17	)	)	PUNCT
dpc-5918	263	18	pihl	pihl	NOUN
dpc-5918	263	19	forms	form	VERB
dpc-5918	263	20	an	an	DET
dpc-5918	263	21	interaction	interaction	NOUN
dpc-5918	263	22	with	with	ADP
dpc-5918	263	23	grwd1	grwd1	NOUN
dpc-5918	263	24	and	and	CCONJ
dpc-5918	263	25	rpl11	rpl11	NOUN
dpc-5918	263	26	that	that	PRON
dpc-5918	263	27	degrades	degrade	VERB
dpc-5918	263	28	p53	p53	NOUN
dpc-5918	263	29	[	[	X
dpc-5918	263	30	20	20	NUM
dpc-5918	263	31	]	]	PUNCT
dpc-5918	263	32	.	.	PUNCT
dpc-5918	264	1	the	the	DET
dpc-5918	264	2	mechanism	mechanism	NOUN
dpc-5918	264	3	by	by	ADP
dpc-5918	264	4	which	which	PRON
dpc-5918	264	5	grwd1	grwd1	NOUN
dpc-5918	264	6	facilitates	facilitate	VERB
dpc-5918	264	7	cancer	cancer	NOUN
dpc-5918	264	8	development	development	NOUN
dpc-5918	264	9	through	through	ADP
dpc-5918	264	10	inhibition	inhibition	NOUN
dpc-5918	264	11	of	of	ADP
dpc-5918	264	12	the	the	DET
dpc-5918	264	13	tumor	tumor	NOUN
dpc-5918	264	14	suppressor	suppressor	NOUN
dpc-5918	264	15	p53	p53	NOUN
dpc-5918	264	16	is	be	AUX
dpc-5918	264	17	further	far	ADV
dpc-5918	264	18	upheld	uphold	VERB
dpc-5918	264	19	by	by	ADP
dpc-5918	264	20	our	our	PRON
dpc-5918	264	21	data	datum	NOUN
dpc-5918	264	22	,	,	PUNCT
dpc-5918	264	23	which	which	PRON
dpc-5918	264	24	demonstrate	demonstrate	VERB
dpc-5918	264	25	that	that	SCONJ
dpc-5918	264	26	repression	repression	NOUN
dpc-5918	264	27	of	of	ADP
dpc-5918	264	28	grwd1	grwd1	NOUN
dpc-5918	264	29	caused	cause	VERB
dpc-5918	264	30	stabilization	stabilization	NOUN
dpc-5918	264	31	of	of	ADP
dpc-5918	264	32	p53	p53	NOUN
dpc-5918	264	33	and	and	CCONJ
dpc-5918	264	34	the	the	DET
dpc-5918	264	35	activation	activation	NOUN
dpc-5918	264	36	of	of	ADP
dpc-5918	264	37	apoptotic	apoptotic	ADJ
dpc-5918	264	38	pathways	pathway	NOUN
dpc-5918	264	39	(	(	PUNCT
dpc-5918	264	40	figure	figure	NOUN
dpc-5918	264	41	4c	4c	NOUN
dpc-5918	264	42	)	)	PUNCT
dpc-5918	264	43	.	.	PUNCT
dpc-5918	265	1	on	on	ADP
dpc-5918	265	2	melanoma	melanoma	NOUN
dpc-5918	265	3	cells	cell	NOUN
dpc-5918	265	4	are	be	AUX
dpc-5918	265	5	cancer	cancer	NOUN
dpc-5918	265	6	-	-	PUNCT
dpc-5918	265	7	specific	specific	ADJ
dpc-5918	265	8	,	,	PUNCT
dpc-5918	265	9	we	we	PRON
dpc-5918	265	10	conducted	conduct	VERB
dpc-5918	265	11	a	a	DET
dpc-5918	265	12	proliferation	proliferation	NOUN
dpc-5918	265	13	analysis	analysis	NOUN
dpc-5918	265	14	using	use	VERB
dpc-5918	265	15	a	a	DET
dpc-5918	265	16	second	second	ADJ
dpc-5918	265	17	cancer	cancer	NOUN
dpc-5918	265	18	cell	cell	NOUN
dpc-5918	265	19	line	line	NOUN
dpc-5918	265	20	.	.	PUNCT
dpc-5918	266	1	suppression	suppression	NOUN
dpc-5918	266	2	of	of	ADP
dpc-5918	266	3	grwd1	grwd1	NOUN
dpc-5918	266	4	expression	expression	NOUN
dpc-5918	266	5	in	in	ADP
dpc-5918	266	6	a2780	a2780	ADJ
dpc-5918	266	7	ovarian	ovarian	ADJ
dpc-5918	266	8	cancer	cancer	NOUN
dpc-5918	266	9	cells	cell	NOUN
dpc-5918	266	10	resulted	result	VERB
dpc-5918	266	11	in	in	ADP
dpc-5918	266	12	a	a	DET
dpc-5918	266	13	similar	similar	ADJ
dpc-5918	266	14	inhibitory	inhibitory	ADJ
dpc-5918	266	15	effect	effect	NOUN
dpc-5918	266	16	on	on	ADP
dpc-5918	266	17	cell	cell	NOUN
dpc-5918	266	18	proliferation	proliferation	NOUN
dpc-5918	266	19	,	,	PUNCT
dpc-5918	266	20	demonstrating	demonstrate	VERB
dpc-5918	266	21	that	that	SCONJ
dpc-5918	266	22	grwd1	grwd1	PROPN
dpc-5918	266	23	plays	play	VERB
dpc-5918	266	24	a	a	DET
dpc-5918	266	25	critical	critical	ADJ
dpc-5918	266	26	role	role	NOUN
dpc-5918	266	27	in	in	ADP
dpc-5918	266	28	cancer	cancer	NOUN
dpc-5918	266	29	cell	cell	NOUN
dpc-5918	266	30	growth	growth	NOUN
dpc-5918	266	31	beyond	beyond	ADP
dpc-5918	266	32	melanoma	melanoma	NOUN
dpc-5918	266	33	(	(	PUNCT
dpc-5918	266	34	figure	figure	NOUN
dpc-5918	266	35	4d	4d	NUM
dpc-5918	266	36	)	)	PUNCT
dpc-5918	266	37	.	.	PUNCT
dpc-5918	267	1	no	no	DET
dpc-5918	267	2	association	association	NOUN
dpc-5918	267	3	was	be	AUX
dpc-5918	267	4	found	find	VERB
dpc-5918	267	5	between	between	ADP
dpc-5918	267	6	grwd1	grwd1	NOUN
dpc-5918	267	7	expression	expression	NOUN
dpc-5918	267	8	and	and	CCONJ
dpc-5918	267	9	melanoma	melanoma	NOUN
dpc-5918	267	10	subtypes	subtype	NOUN
dpc-5918	267	11	we	we	PRON
dpc-5918	267	12	analyzed	analyze	VERB
dpc-5918	267	13	the	the	DET
dpc-5918	267	14	expression	expression	NOUN
dpc-5918	267	15	of	of	ADP
dpc-5918	267	16	grwd1	grwd1	NOUN
dpc-5918	267	17	in	in	ADP
dpc-5918	267	18	a	a	DET
dpc-5918	267	19	cohort	cohort	NOUN
dpc-5918	267	20	of	of	ADP
dpc-5918	267	21	melanoma	melanoma	NOUN
dpc-5918	267	22	ffpe	ffpe	NOUN
dpc-5918	267	23	tumor	tumor	NOUN
dpc-5918	267	24	samples	sample	NOUN
dpc-5918	267	25	.	.	PUNCT
dpc-5918	268	1	among	among	ADP
dpc-5918	268	2	the	the	DET
dpc-5918	268	3	37	37	NUM
dpc-5918	268	4	patients	patient	NOUN
dpc-5918	268	5	included	include	VERB
dpc-5918	268	6	in	in	ADP
dpc-5918	268	7	the	the	DET
dpc-5918	268	8	study	study	NOUN
dpc-5918	268	9	,	,	PUNCT
dpc-5918	268	10	15	15	NUM
dpc-5918	268	11	(	(	PUNCT
dpc-5918	268	12	40.5	40.5	NUM
dpc-5918	268	13	%	%	NOUN
dpc-5918	268	14	)	)	PUNCT
dpc-5918	268	15	were	be	AUX
dpc-5918	268	16	female	female	ADJ
dpc-5918	268	17	,	,	PUNCT
dpc-5918	268	18	and	and	CCONJ
dpc-5918	268	19	22	22	NUM
dpc-5918	268	20	(	(	PUNCT
dpc-5918	268	21	59.5	59.5	NUM
dpc-5918	268	22	%	%	NOUN
dpc-5918	268	23	)	)	PUNCT
dpc-5918	268	24	were	be	AUX
dpc-5918	268	25	male	male	ADJ
dpc-5918	268	26	.	.	PUNCT
dpc-5918	269	1	the	the	DET
dpc-5918	269	2	mean	mean	ADJ
dpc-5918	269	3	age	age	NOUN
dpc-5918	269	4	was	be	AUX
dpc-5918	269	5	68.1±14.2	68.1±14.2	NUM
dpc-5918	269	6	years	year	NOUN
dpc-5918	269	7	.	.	PUNCT
dpc-5918	270	1	regarding	regard	VERB
dpc-5918	270	2	the	the	DET
dpc-5918	270	3	melanoma	melanoma	NOUN
dpc-5918	270	4	subtypes	subtype	NOUN
dpc-5918	270	5	in	in	ADP
dpc-5918	270	6	the	the	DET
dpc-5918	270	7	examined	examine	VERB
dpc-5918	270	8	specimens	specimen	NOUN
dpc-5918	270	9	,	,	PUNCT
dpc-5918	270	10	54.1	54.1	NUM
dpc-5918	270	11	%	%	NOUN
dpc-5918	270	12	were	be	AUX
dpc-5918	270	13	nodular	nodular	ADJ
dpc-5918	270	14	melanoma	melanoma	NOUN
dpc-5918	270	15	,	,	PUNCT
dpc-5918	270	16	and	and	CCONJ
dpc-5918	270	17	32.4	32.4	NUM
dpc-5918	270	18	%	%	NOUN
dpc-5918	270	19	were	be	AUX
dpc-5918	270	20	acral	acral	ADJ
dpc-5918	270	21	lentiginous	lentiginous	ADJ
dpc-5918	270	22	melanoma	melanoma	NOUN
dpc-5918	270	23	.	.	PUNCT
dpc-5918	271	1	three	three	NUM
dpc-5918	271	2	specimens	specimen	NOUN
dpc-5918	271	3	were	be	AUX
dpc-5918	271	4	from	from	ADP
dpc-5918	271	5	metastatic	metastatic	ADJ
dpc-5918	271	6	lesions	lesion	NOUN
dpc-5918	271	7	.	.	PUNCT
dpc-5918	272	1	the	the	DET
dpc-5918	272	2	tumor	tumor	NOUN
dpc-5918	272	3	was	be	AUX
dpc-5918	272	4	localized	localize	VERB
dpc-5918	272	5	in	in	ADP
dpc-5918	272	6	the	the	DET
dpc-5918	272	7	extremities	extremity	NOUN
dpc-5918	272	8	in	in	ADP
dpc-5918	272	9	62.2	62.2	NUM
dpc-5918	272	10	%	%	NOUN
dpc-5918	272	11	of	of	ADP
dpc-5918	272	12	cases	case	NOUN
dpc-5918	272	13	,	,	PUNCT
dpc-5918	272	14	with	with	ADP
dpc-5918	272	15	the	the	DET
dpc-5918	272	16	second	second	ADJ
dpc-5918	272	17	most	most	ADV
dpc-5918	272	18	common	common	ADJ
dpc-5918	272	19	localization	localization	NOUN
dpc-5918	272	20	being	be	AUX
dpc-5918	272	21	the	the	DET
dpc-5918	272	22	head	head	NOUN
dpc-5918	272	23	and	and	CCONJ
dpc-5918	272	24	neck	neck	NOUN
dpc-5918	272	25	region	region	NOUN
dpc-5918	272	26	(	(	PUNCT
dpc-5918	272	27	24.3	24.3	NUM
dpc-5918	272	28	%	%	NOUN
dpc-5918	272	29	)	)	PUNCT
dpc-5918	272	30	.	.	PUNCT
dpc-5918	273	1	metastasis	metastasis	PRON
dpc-5918	273	2	was	be	AUX
dpc-5918	273	3	observed	observe	VERB
dpc-5918	273	4	in	in	ADP
dpc-5918	273	5	62.2	62.2	NUM
dpc-5918	273	6	%	%	NOUN
dpc-5918	273	7	of	of	ADP
dpc-5918	273	8	the	the	DET
dpc-5918	273	9	cases	case	NOUN
dpc-5918	273	10	.	.	PUNCT
dpc-5918	274	1	the	the	DET
dpc-5918	274	2	survival	survival	NOUN
dpc-5918	274	3	time	time	NOUN
dpc-5918	274	4	of	of	ADP
dpc-5918	274	5	deceased	deceased	ADJ
dpc-5918	274	6	patients	patient	NOUN
dpc-5918	274	7	after	after	SCONJ
dpc-5918	274	8	diagnosis	diagnosis	NOUN
dpc-5918	274	9	ranged	range	VERB
dpc-5918	274	10	from	from	ADP
dpc-5918	274	11	one	one	NUM
dpc-5918	274	12	to	to	ADP
dpc-5918	274	13	39	39	NUM
dpc-5918	274	14	months	month	NOUN
dpc-5918	274	15	,	,	PUNCT
dpc-5918	274	16	with	with	ADP
dpc-5918	274	17	an	an	DET
dpc-5918	274	18	average	average	NOUN
dpc-5918	274	19	of	of	ADP
dpc-5918	274	20	13.1±12.7	13.1±12.7	NUM
dpc-5918	274	21	months	month	NOUN
dpc-5918	274	22	.	.	PUNCT
dpc-5918	275	1	we	we	PRON
dpc-5918	275	2	examined	examine	VERB
dpc-5918	275	3	the	the	DET
dpc-5918	275	4	staining	stain	VERB
dpc-5918	275	5	status	status	NOUN
dpc-5918	275	6	of	of	ADP
dpc-5918	275	7	melanoma	melanoma	NOUN
dpc-5918	275	8	tumor	tumor	NOUN
dpc-5918	275	9	samples	sample	NOUN
dpc-5918	275	10	with	with	ADP
dpc-5918	275	11	grwd1	grwd1	NOUN
dpc-5918	275	12	and	and	CCONJ
dpc-5918	275	13	classified	classify	VERB
dpc-5918	275	14	the	the	DET
dpc-5918	275	15	staining	stain	VERB
dpc-5918	275	16	intensity	intensity	NOUN
dpc-5918	275	17	as	as	ADP
dpc-5918	275	18	mild	mild	ADJ
dpc-5918	275	19	,	,	PUNCT
dpc-5918	275	20	moderate	moderate	ADJ
dpc-5918	275	21	,	,	PUNCT
dpc-5918	275	22	or	or	CCONJ
dpc-5918	275	23	severe	severe	ADJ
dpc-5918	275	24	(	(	PUNCT
dpc-5918	275	25	figure	figure	NOUN
dpc-5918	275	26	s1	s1	NOUN
dpc-5918	275	27	)	)	PUNCT
dpc-5918	275	28	.	.	PUNCT
dpc-5918	276	1	to	to	PART
dpc-5918	276	2	compare	compare	VERB
dpc-5918	276	3	the	the	DET
dpc-5918	276	4	staining	stain	VERB
dpc-5918	276	5	intensity	intensity	NOUN
dpc-5918	276	6	among	among	ADP
dpc-5918	276	7	different	different	ADJ
dpc-5918	276	8	subgroups	subgroup	NOUN
dpc-5918	276	9	,	,	PUNCT
dpc-5918	276	10	we	we	PRON
dpc-5918	276	11	divided	divide	VERB
dpc-5918	276	12	the	the	DET
dpc-5918	276	13	staining	stain	VERB
dpc-5918	276	14	intensity	intensity	NOUN
dpc-5918	276	15	into	into	ADP
dpc-5918	276	16	two	two	NUM
dpc-5918	276	17	groups	group	NOUN
dpc-5918	276	18	as	as	ADP
dpc-5918	276	19	mild/	mild/	NUM
dpc-5918	276	20	moderate	moderate	ADJ
dpc-5918	276	21	and	and	CCONJ
dpc-5918	276	22	severe	severe	ADJ
dpc-5918	276	23	.	.	PUNCT
dpc-5918	277	1	we	we	PRON
dpc-5918	277	2	could	could	AUX
dpc-5918	277	3	not	not	PART
dpc-5918	277	4	obtain	obtain	VERB
dpc-5918	277	5	survival	survival	ADJ
dpc-5918	277	6	information	information	NOUN
dpc-5918	277	7	for	for	ADP
dpc-5918	277	8	some	some	PRON
dpc-5918	277	9	of	of	ADP
dpc-5918	277	10	the	the	DET
dpc-5918	277	11	patients	patient	NOUN
dpc-5918	277	12	whose	whose	DET
dpc-5918	277	13	biopsy	biopsy	NOUN
dpc-5918	277	14	specimens	specimen	NOUN
dpc-5918	277	15	we	we	PRON
dpc-5918	277	16	examined	examine	VERB
dpc-5918	277	17	.	.	PUNCT
dpc-5918	278	1	perhaps	perhaps	ADV
dpc-5918	278	2	due	due	ADP
dpc-5918	278	3	to	to	ADP
dpc-5918	278	4	the	the	DET
dpc-5918	278	5	small	small	ADJ
dpc-5918	278	6	sample	sample	NOUN
dpc-5918	278	7	size	size	NOUN
dpc-5918	278	8	,	,	PUNCT
dpc-5918	278	9	there	there	PRON
dpc-5918	278	10	was	be	VERB
dpc-5918	278	11	no	no	DET
dpc-5918	278	12	significant	significant	ADJ
dpc-5918	278	13	difference	difference	NOUN
dpc-5918	278	14	in	in	ADP
dpc-5918	278	15	survival	survival	NOUN
dpc-5918	278	16	between	between	ADP
dpc-5918	278	17	the	the	DET
dpc-5918	278	18	two	two	NUM
dpc-5918	278	19	groups	group	NOUN
dpc-5918	278	20	(	(	PUNCT
dpc-5918	278	21	figure	figure	NOUN
dpc-5918	278	22	s2	s2	PROPN
dpc-5918	278	23	)	)	PUNCT
dpc-5918	278	24	.	.	PUNCT
dpc-5918	279	1	grwd1	grwd1	ADJ
dpc-5918	279	2	staining	stain	VERB
dpc-5918	279	3	intensity	intensity	NOUN
dpc-5918	279	4	was	be	AUX
dpc-5918	279	5	mild	mild	ADJ
dpc-5918	279	6	/	/	SYM
dpc-5918	279	7	moderate	moderate	ADJ
dpc-5918	279	8	in	in	ADP
dpc-5918	279	9	59.5	59.5	NUM
dpc-5918	279	10	%	%	NOUN
dpc-5918	279	11	of	of	ADP
dpc-5918	279	12	patients	patient	NOUN
dpc-5918	279	13	and	and	CCONJ
dpc-5918	279	14	severe	severe	ADJ
dpc-5918	279	15	in	in	ADP
dpc-5918	279	16	40.5	40.5	NUM
dpc-5918	279	17	%	%	NOUN
dpc-5918	279	18	(	(	PUNCT
dpc-5918	279	19	table	table	NOUN
dpc-5918	279	20	s1	s1	NOUN
dpc-5918	279	21	)	)	PUNCT
dpc-5918	279	22	.	.	PUNCT
dpc-5918	280	1	in	in	ADP
dpc-5918	280	2	the	the	DET
dpc-5918	280	3	comparison	comparison	NOUN
dpc-5918	280	4	of	of	ADP
dpc-5918	280	5	staining	stain	VERB
dpc-5918	280	6	intensity	intensity	NOUN
dpc-5918	280	7	across	across	ADP
dpc-5918	280	8	different	different	ADJ
dpc-5918	280	9	groups	group	NOUN
dpc-5918	280	10	,	,	PUNCT
dpc-5918	280	11	severe	severe	ADJ
dpc-5918	280	12	staining	stain	VERB
dpc-5918	280	13	was	be	AUX
dpc-5918	280	14	significantly	significantly	ADV
dpc-5918	280	15	more	more	ADV
dpc-5918	280	16	frequent	frequent	ADJ
dpc-5918	280	17	in	in	ADP
dpc-5918	280	18	female	female	ADJ
dpc-5918	280	19	patients	patient	NOUN
dpc-5918	280	20	than	than	ADP
dpc-5918	280	21	in	in	ADP
dpc-5918	280	22	male	male	ADJ
dpc-5918	280	23	patients	patient	NOUN
dpc-5918	280	24	(	(	PUNCT
dpc-5918	280	25	p=0.020	p=0.020	ADV
dpc-5918	280	26	)	)	PUNCT
dpc-5918	280	27	.	.	PUNCT
dpc-5918	281	1	however	however	ADV
dpc-5918	281	2	,	,	PUNCT
dpc-5918	281	3	no	no	DET
dpc-5918	281	4	statistically	statistically	ADV
dpc-5918	281	5	significant	significant	ADJ
dpc-5918	281	6	difference	difference	NOUN
dpc-5918	281	7	was	be	AUX
dpc-5918	281	8	observed	observe	VERB
dpc-5918	281	9	in	in	ADP
dpc-5918	281	10	staining	stain	VERB
dpc-5918	281	11	intensity	intensity	NOUN
dpc-5918	281	12	based	base	VERB
dpc-5918	281	13	on	on	ADP
dpc-5918	281	14	melanoma	melanoma	NOUN
dpc-5918	281	15	subtype	subtype	NOUN
dpc-5918	281	16	,	,	PUNCT
dpc-5918	281	17	lesion	lesion	NOUN
dpc-5918	281	18	size	size	NOUN
dpc-5918	281	19	,	,	PUNCT
dpc-5918	281	20	localization	localization	NOUN
dpc-5918	281	21	,	,	PUNCT
dpc-5918	281	22	or	or	CCONJ
dpc-5918	281	23	metastasis	metastasis	NOUN
dpc-5918	281	24	(	(	PUNCT
dpc-5918	281	25	p>0.05	p>0.05	NOUN
dpc-5918	281	26	)	)	PUNCT
dpc-5918	281	27	(	(	PUNCT
dpc-5918	281	28	table	table	NOUN
dpc-5918	281	29	s2	s2	PROPN
dpc-5918	281	30	)	)	PUNCT
dpc-5918	281	31	.	.	PUNCT
dpc-5918	282	1	patients	patient	NOUN
dpc-5918	282	2	with	with	ADP
dpc-5918	282	3	metastasis	metastasis	NOUN
dpc-5918	282	4	had	have	VERB
dpc-5918	282	5	a	a	DET
dpc-5918	282	6	significantly	significantly	ADV
dpc-5918	282	7	higher	high	ADJ
dpc-5918	282	8	mean	mean	ADJ
dpc-5918	282	9	breslow	breslow	ADJ
dpc-5918	282	10	score	score	NOUN
dpc-5918	282	11	compared	compare	VERB
dpc-5918	282	12	to	to	ADP
dpc-5918	282	13	those	those	PRON
dpc-5918	282	14	without	without	ADP
dpc-5918	282	15	metastasis	metastasis	NOUN
dpc-5918	282	16	(	(	PUNCT
dpc-5918	282	17	p=0.029	p=0.029	PROPN
dpc-5918	282	18	)	)	PUNCT
dpc-5918	282	19	.	.	PUNCT
dpc-5918	283	1	in	in	ADP
dpc-5918	283	2	nodular	nodular	ADJ
dpc-5918	283	3	melanoma	melanoma	NOUN
dpc-5918	283	4	,	,	PUNCT
dpc-5918	283	5	the	the	DET
dpc-5918	283	6	mean	mean	ADJ
dpc-5918	283	7	breslow	breslow	ADJ
dpc-5918	283	8	score	score	NOUN
dpc-5918	283	9	and	and	CCONJ
dpc-5918	283	10	mitotic	mitotic	ADJ
dpc-5918	283	11	rate	rate	NOUN
dpc-5918	283	12	were	be	AUX
dpc-5918	283	13	significantly	significantly	ADV
dpc-5918	283	14	higher	high	ADJ
dpc-5918	283	15	compared	compare	VERB
dpc-5918	283	16	to	to	ADP
dpc-5918	283	17	acral	acral	ADJ
dpc-5918	283	18	lentiginous	lentiginous	ADJ
dpc-5918	283	19	melanoma	melanoma	NOUN
dpc-5918	283	20	(	(	PUNCT
dpc-5918	283	21	p=0.034	p=0.034	X
dpc-5918	283	22	,	,	PUNCT
dpc-5918	283	23	p=0.012	p=0.012	PRON
dpc-5918	283	24	,	,	PUNCT
dpc-5918	283	25	respectively	respectively	ADV
dpc-5918	283	26	)	)	PUNCT
dpc-5918	283	27	(	(	PUNCT
dpc-5918	283	28	table	table	NOUN
dpc-5918	283	29	s3	s3	PROPN
dpc-5918	283	30	)	)	PUNCT
dpc-5918	283	31	.	.	PUNCT
dpc-5918	284	1	correlation	correlation	NOUN
dpc-5918	284	2	analysis	analysis	NOUN
dpc-5918	284	3	revealed	reveal	VERB
dpc-5918	284	4	a	a	DET
dpc-5918	284	5	significant	significant	ADJ
dpc-5918	284	6	positive	positive	ADJ
dpc-5918	284	7	relationship	relationship	NOUN
dpc-5918	284	8	between	between	ADP
dpc-5918	284	9	age	age	NOUN
dpc-5918	284	10	and	and	CCONJ
dpc-5918	284	11	breslow	breslow	NOUN
dpc-5918	284	12	score	score	NOUN
dpc-5918	284	13	,	,	PUNCT
dpc-5918	284	14	mitotic	mitotic	ADJ
dpc-5918	284	15	rate	rate	NOUN
dpc-5918	284	16	,	,	PUNCT
dpc-5918	284	17	and	and	CCONJ
dpc-5918	284	18	lesion	lesion	NOUN
dpc-5918	284	19	size	size	NOUN
dpc-5918	284	20	.	.	PUNCT
dpc-5918	285	1	there	there	PRON
dpc-5918	285	2	was	be	VERB
dpc-5918	285	3	also	also	ADV
dpc-5918	285	4	a	a	DET
dpc-5918	285	5	significant	significant	ADJ
dpc-5918	285	6	positive	positive	ADJ
dpc-5918	285	7	correlation	correlation	NOUN
dpc-5918	285	8	between	between	ADP
dpc-5918	285	9	breslow	breslow	NOUN
dpc-5918	285	10	score	score	NOUN
dpc-5918	285	11	and	and	CCONJ
dpc-5918	285	12	lesion	lesion	NOUN
dpc-5918	285	13	size	size	NOUN
dpc-5918	285	14	,	,	PUNCT
dpc-5918	285	15	while	while	SCONJ
dpc-5918	285	16	mitotic	mitotic	ADJ
dpc-5918	285	17	rate	rate	NOUN
dpc-5918	285	18	showed	show	VERB
dpc-5918	285	19	a	a	DET
dpc-5918	285	20	significant	significant	ADJ
dpc-5918	285	21	negative	negative	ADJ
dpc-5918	285	22	correlation	correlation	NOUN
dpc-5918	285	23	with	with	ADP
dpc-5918	285	24	both	both	DET
dpc-5918	285	25	survival	survival	NOUN
dpc-5918	285	26	and	and	CCONJ
dpc-5918	285	27	staining	stain	VERB
dpc-5918	285	28	intensity	intensity	NOUN
dpc-5918	285	29	(	(	PUNCT
dpc-5918	285	30	table	table	NOUN
dpc-5918	285	31	s4	s4	PROPN
dpc-5918	285	32	)	)	PUNCT
dpc-5918	285	33	.	.	PUNCT
dpc-5918	286	1	we	we	PRON
dpc-5918	286	2	also	also	ADV
dpc-5918	286	3	collected	collect	VERB
dpc-5918	286	4	demographic	demographic	ADJ
dpc-5918	286	5	and	and	CCONJ
dpc-5918	286	6	clinical	clinical	ADJ
dpc-5918	286	7	data	datum	NOUN
dpc-5918	286	8	of	of	ADP
dpc-5918	286	9	all	all	DET
dpc-5918	286	10	patients	patient	NOUN
dpc-5918	286	11	including	include	VERB
dpc-5918	286	12	age	age	NOUN
dpc-5918	286	13	,	,	PUNCT
dpc-5918	286	14	sex	sex	NOUN
dpc-5918	286	15	,	,	PUNCT
dpc-5918	286	16	melanoma	melanoma	NOUN
dpc-5918	286	17	types	type	NOUN
dpc-5918	286	18	,	,	PUNCT
dpc-5918	286	19	metastasis	metastasis	NOUN
dpc-5918	286	20	,	,	PUNCT
dpc-5918	286	21	localization	localization	NOUN
dpc-5918	286	22	,	,	PUNCT
dpc-5918	286	23	and	and	CCONJ
dpc-5918	286	24	grwd1	grwd1	ADJ
dpc-5918	286	25	staining	stain	VERB
dpc-5918	286	26	intensity	intensity	NOUN
dpc-5918	286	27	in	in	ADP
dpc-5918	286	28	a	a	DET
dpc-5918	286	29	separate	separate	ADJ
dpc-5918	286	30	table	table	NOUN
dpc-5918	286	31	(	(	PUNCT
dpc-5918	286	32	table	table	NOUN
dpc-5918	286	33	s5	s5	NOUN
dpc-5918	286	34	)	)	PUNCT
dpc-5918	286	35	.	.	PUNCT
dpc-5918	287	1	original	original	ADJ
dpc-5918	287	2	article	article	NOUN
dpc-5918	287	3	|	|	ADV
dpc-5918	287	4	dermatol	dermatol	ADJ
dpc-5918	287	5	pract	pract	NOUN
dpc-5918	287	6	concept	concept	NOUN
dpc-5918	287	7	.	.	PUNCT
dpc-5918	288	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	288	2	9	9	NUM
dpc-5918	288	3	2	2	NUM
dpc-5918	288	4	.	.	PUNCT
dpc-5918	289	1	vaienti	vaienti	PROPN
dpc-5918	289	2	s	s	PROPN
dpc-5918	289	3	,	,	PUNCT
dpc-5918	289	4	calzari	calzari	NOUN
dpc-5918	289	5	p	p	NOUN
dpc-5918	289	6	,	,	PUNCT
dpc-5918	289	7	nazzaro	nazzaro	ADJ
dpc-5918	289	8	g.	g.	PROPN
dpc-5918	289	9	topical	topical	ADJ
dpc-5918	289	10	treatment	treatment	NOUN
dpc-5918	289	11	of	of	ADP
dpc-5918	289	12	melanoma	melanoma	NOUN
dpc-5918	289	13	in	in	ADP
dpc-5918	289	14	situ	situ	NOUN
dpc-5918	289	15	,	,	PUNCT
dpc-5918	289	16	lentigo	lentigo	ADJ
dpc-5918	289	17	maligna	maligna	PROPN
dpc-5918	289	18	,	,	PUNCT
dpc-5918	289	19	and	and	CCONJ
dpc-5918	289	20	lentigo	lentigo	ADJ
dpc-5918	289	21	maligna	maligna	NOUN
dpc-5918	289	22	melanoma	melanoma	PROPN
dpc-5918	289	23	with	with	ADP
dpc-5918	289	24	imiquimod	imiquimod	PROPN
dpc-5918	289	25	cream	cream	NOUN
dpc-5918	289	26	:	:	PUNCT
dpc-5918	289	27	a	a	DET
dpc-5918	289	28	systematic	systematic	ADJ
dpc-5918	289	29	review	review	NOUN
dpc-5918	289	30	of	of	ADP
dpc-5918	289	31	the	the	DET
dpc-5918	289	32	literature	literature	NOUN
dpc-5918	289	33	.	.	PUNCT
dpc-5918	290	1	dermatol	dermatol	NOUN
dpc-5918	290	2	ther	ther	ADV
dpc-5918	290	3	(	(	PUNCT
dpc-5918	290	4	heidelb	heidelb	NOUN
dpc-5918	290	5	)	)	PUNCT
dpc-5918	290	6	.	.	PUNCT
dpc-5918	291	1	2023;13(10):2187	2023;13(10):2187	X
dpc-5918	291	2	-	-	SYM
dpc-5918	291	3	2215	2215	NUM
dpc-5918	291	4	.	.	PUNCT
dpc-5918	292	1	doi	doi	NOUN
dpc-5918	292	2	:	:	PUNCT
dpc-5918	292	3	10.1007	10.1007	NUM
dpc-5918	292	4	/s13555	/s13555	NUM
dpc-5918	292	5	-	-	PUNCT
dpc-5918	292	6	023	023	NUM
dpc-5918	292	7	-	-	PUNCT
dpc-5918	292	8	00993	00993	NUM
dpc-5918	292	9	-	-	PUNCT
dpc-5918	292	10	1	1	NUM
dpc-5918	292	11	.	.	PUNCT
dpc-5918	293	1	epub	epub	NOUN
dpc-5918	293	2	2023	2023	NUM
dpc-5918	293	3	aug	aug	PROPN
dpc-5918	293	4	24	24	NUM
dpc-5918	293	5	.	.	PUNCT
dpc-5918	294	1	pmid	pmid	NOUN
dpc-5918	294	2	:	:	PUNCT
dpc-5918	294	3	37615838	37615838	NUM
dpc-5918	294	4	;	;	PUNCT
dpc-5918	294	5	pmcid	pmcid	PROPN
dpc-5918	294	6	:	:	PUNCT
dpc-5918	294	7	pmc10539275	pmc10539275	NOUN
dpc-5918	294	8	.	.	PUNCT
dpc-5918	295	1	3	3	X
dpc-5918	295	2	.	.	X
dpc-5918	295	3	gosman	gosman	PROPN
dpc-5918	295	4	lm	lm	PROPN
dpc-5918	295	5	,	,	PUNCT
dpc-5918	295	6	țăpoi	țăpoi	PROPN
dpc-5918	295	7	da	da	PROPN
dpc-5918	295	8	,	,	PUNCT
dpc-5918	295	9	costache	costache	NOUN
dpc-5918	295	10	m.	m.	NOUN
dpc-5918	295	11	cutaneous	cutaneous	ADJ
dpc-5918	295	12	melanoma	melanoma	NOUN
dpc-5918	295	13	:	:	PUNCT
dpc-5918	295	14	a	a	DET
dpc-5918	295	15	review	review	NOUN
dpc-5918	295	16	of	of	ADP
dpc-5918	295	17	multifactorial	multifactorial	ADJ
dpc-5918	295	18	pathogenesis	pathogenesis	NOUN
dpc-5918	295	19	,	,	PUNCT
dpc-5918	295	20	immunohistochemistry	immunohistochemistry	NOUN
dpc-5918	295	21	,	,	PUNCT
dpc-5918	295	22	and	and	CCONJ
dpc-5918	295	23	emerging	emerge	VERB
dpc-5918	295	24	biomarkers	biomarker	NOUN
dpc-5918	295	25	for	for	ADP
dpc-5918	295	26	early	early	ADJ
dpc-5918	295	27	detection	detection	NOUN
dpc-5918	295	28	and	and	CCONJ
dpc-5918	295	29	management	management	NOUN
dpc-5918	295	30	.	.	PUNCT
dpc-5918	296	1	int	int	PROPN
dpc-5918	296	2	j	j	PROPN
dpc-5918	296	3	mol	mol	ADP
dpc-5918	296	4	sci	sci	PROPN
dpc-5918	296	5	.	.	PUNCT
dpc-5918	297	1	2023;24(21):15881	2023;24(21):15881	NUM
dpc-5918	297	2	.	.	PUNCT
dpc-5918	297	3	doi	doi	NOUN
dpc-5918	297	4	:	:	PUNCT
dpc-5918	297	5	10.3390	10.3390	NUM
dpc-5918	297	6	/ijms242115881	/ijms242115881	PUNCT
dpc-5918	297	7	.	.	PUNCT
dpc-5918	298	1	pmid	pmid	NOUN
dpc-5918	298	2	:	:	PUNCT
dpc-5918	298	3	37958863	37958863	NUM
dpc-5918	298	4	;	;	PUNCT
dpc-5918	298	5	pmcid	pmcid	ADJ
dpc-5918	298	6	:	:	PUNCT
dpc-5918	298	7	pmc10650804	pmc10650804	NOUN
dpc-5918	298	8	.	.	PUNCT
dpc-5918	299	1	4	4	X
dpc-5918	299	2	.	.	X
dpc-5918	299	3	rastrelli	rastrelli	PROPN
dpc-5918	299	4	m	m	PROPN
dpc-5918	299	5	,	,	PUNCT
dpc-5918	299	6	tropea	tropea	PROPN
dpc-5918	299	7	s	s	PROPN
dpc-5918	299	8	,	,	PUNCT
dpc-5918	299	9	rossi	rossi	PROPN
dpc-5918	299	10	cr	cr	PROPN
dpc-5918	299	11	,	,	PUNCT
dpc-5918	299	12	alaibac	alaibac	PROPN
dpc-5918	299	13	m.	m.	NOUN
dpc-5918	299	14	melanoma	melanoma	PROPN
dpc-5918	299	15	:	:	PUNCT
dpc-5918	299	16	epidemiology	epidemiology	NOUN
dpc-5918	299	17	,	,	PUNCT
dpc-5918	299	18	risk	risk	NOUN
dpc-5918	299	19	factors	factor	NOUN
dpc-5918	299	20	,	,	PUNCT
dpc-5918	299	21	pathogenesis	pathogenesis	NOUN
dpc-5918	299	22	,	,	PUNCT
dpc-5918	299	23	diagnosis	diagnosis	NOUN
dpc-5918	299	24	and	and	CCONJ
dpc-5918	299	25	classification	classification	NOUN
dpc-5918	299	26	.	.	PUNCT
dpc-5918	300	1	in	in	ADP
dpc-5918	300	2	vivo	vivo	NOUN
dpc-5918	300	3	.	.	PUNCT
dpc-5918	301	1	2014;28(6):1005	2014;28(6):1005	NUM
dpc-5918	301	2	-	-	SYM
dpc-5918	301	3	11	11	NUM
dpc-5918	301	4	.	.	PUNCT
dpc-5918	302	1	pmid	pmid	NOUN
dpc-5918	302	2	:	:	PUNCT
dpc-5918	302	3	25398793	25398793	NUM
dpc-5918	302	4	.	.	PUNCT
dpc-5918	303	1	5	5	X
dpc-5918	303	2	.	.	X
dpc-5918	303	3	caini	caini	PROPN
dpc-5918	303	4	s	s	PROPN
dpc-5918	303	5	,	,	PUNCT
dpc-5918	303	6	gandini	gandini	VERB
dpc-5918	303	7	s	s	PROPN
dpc-5918	303	8	,	,	PUNCT
dpc-5918	303	9	sera	sera	NOUN
dpc-5918	303	10	f	f	PROPN
dpc-5918	303	11	,	,	PUNCT
dpc-5918	303	12	et	et	PROPN
dpc-5918	303	13	al	al	PROPN
dpc-5918	303	14	.	.	PUNCT
dpc-5918	304	1	meta	meta	VERB
dpc-5918	304	2	-	-	PUNCT
dpc-5918	304	3	analysis	analysis	NOUN
dpc-5918	304	4	of	of	ADP
dpc-5918	304	5	risk	risk	NOUN
dpc-5918	304	6	factors	factor	NOUN
dpc-5918	304	7	for	for	ADP
dpc-5918	304	8	cutaneous	cutaneous	ADJ
dpc-5918	304	9	melanoma	melanoma	NOUN
dpc-5918	304	10	according	accord	VERB
dpc-5918	304	11	to	to	ADP
dpc-5918	304	12	anatomical	anatomical	ADJ
dpc-5918	304	13	site	site	NOUN
dpc-5918	304	14	and	and	CCONJ
dpc-5918	304	15	clinico	clinico	NOUN
dpc-5918	304	16	-	-	ADJ
dpc-5918	304	17	pathological	pathological	ADJ
dpc-5918	304	18	variant	variant	NOUN
dpc-5918	304	19	.	.	PUNCT
dpc-5918	305	1	eur	eur	PROPN
dpc-5918	305	2	j	j	PROPN
dpc-5918	305	3	cancer	cancer	NOUN
dpc-5918	305	4	.	.	PUNCT
dpc-5918	306	1	2009;45(17	2009;45(17	NUM
dpc-5918	306	2	):	):	PUNCT
dpc-5918	306	3	3054	3054	NUM
dpc-5918	306	4	-	-	SYM
dpc-5918	306	5	63	63	NUM
dpc-5918	306	6	.	.	PUNCT
dpc-5918	307	1	doi	doi	NOUN
dpc-5918	307	2	:	:	PUNCT
dpc-5918	307	3	10.1016	10.1016	NUM
dpc-5918	307	4	/	/	SYM
dpc-5918	307	5	j.ejca.2009.05.009	j.ejca.2009.05.009	PROPN
dpc-5918	307	6	.	.	PUNCT
dpc-5918	308	1	epub	epub	PROPN
dpc-5918	308	2	2009	2009	NUM
dpc-5918	308	3	jun	jun	PROPN
dpc-5918	308	4	21	21	NUM
dpc-5918	308	5	.	.	PUNCT
dpc-5918	309	1	pmid	pmid	NOUN
dpc-5918	309	2	:	:	PUNCT
dpc-5918	309	3	19545997	19545997	NUM
dpc-5918	309	4	.	.	PUNCT
dpc-5918	310	1	6	6	NUM
dpc-5918	310	2	.	.	X
dpc-5918	310	3	zhang	zhang	PROPN
dpc-5918	310	4	j	j	PROPN
dpc-5918	310	5	,	,	PUNCT
dpc-5918	310	6	tian	tian	ADJ
dpc-5918	310	7	h	h	NOUN
dpc-5918	310	8	,	,	PUNCT
dpc-5918	310	9	mao	mao	X
dpc-5918	310	10	l	l	NOUN
dpc-5918	310	11	,	,	PUNCT
dpc-5918	310	12	si	si	PROPN
dpc-5918	310	13	l.	l.	PROPN
dpc-5918	310	14	treatment	treatment	NOUN
dpc-5918	310	15	of	of	ADP
dpc-5918	310	16	acral	acral	ADJ
dpc-5918	310	17	and	and	CCONJ
dpc-5918	310	18	mucosal	mucosal	ADJ
dpc-5918	310	19	melanoma	melanoma	NOUN
dpc-5918	310	20	:	:	PUNCT
dpc-5918	310	21	current	current	ADJ
dpc-5918	310	22	and	and	CCONJ
dpc-5918	310	23	emerging	emerge	VERB
dpc-5918	310	24	targeted	target	VERB
dpc-5918	310	25	therapies	therapy	NOUN
dpc-5918	310	26	.	.	PUNCT
dpc-5918	311	1	crit	crit	PROPN
dpc-5918	311	2	rev	rev	VERB
dpc-5918	311	3	oncol	oncol	ADJ
dpc-5918	311	4	hematol	hematol	NOUN
dpc-5918	311	5	.	.	PUNCT
dpc-5918	312	1	2024;193:104221	2024;193:104221	X
dpc-5918	312	2	.	.	PUNCT
dpc-5918	313	1	doi	doi	NOUN
dpc-5918	313	2	:	:	PUNCT
dpc-5918	313	3	10.1016	10.1016	NUM
dpc-5918	313	4	/	/	SYM
dpc-5918	313	5	j.critrevonc	j.critrevonc	ADJ
dpc-5918	313	6	.2023.104221	.2023.104221	PROPN
dpc-5918	313	7	.	.	PUNCT
dpc-5918	314	1	epub	epub	PROPN
dpc-5918	314	2	2023	2023	NUM
dpc-5918	314	3	nov	nov	PROPN
dpc-5918	314	4	29	29	NUM
dpc-5918	314	5	.	.	PUNCT
dpc-5918	315	1	pmid	pmid	NOUN
dpc-5918	315	2	:	:	PUNCT
dpc-5918	315	3	38036156	38036156	NUM
dpc-5918	315	4	.	.	PUNCT
dpc-5918	316	1	7	7	X
dpc-5918	316	2	.	.	X
dpc-5918	316	3	society	society	PROPN
dpc-5918	316	4	ac	ac	PROPN
dpc-5918	316	5	.	.	PUNCT
dpc-5918	317	1	survival	survival	NOUN
dpc-5918	317	2	rates	rate	NOUN
dpc-5918	317	3	for	for	ADP
dpc-5918	317	4	melanoma	melanoma	NOUN
dpc-5918	317	5	skin	skin	NOUN
dpc-5918	317	6	cancer	cancer	NOUN
dpc-5918	317	7	,	,	PUNCT
dpc-5918	317	8	by	by	ADP
dpc-5918	317	9	stage	stage	NOUN
dpc-5918	317	10	.	.	PUNCT
dpc-5918	318	1	american	american	ADJ
dpc-5918	318	2	cancer	cancer	PROPN
dpc-5918	318	3	society	society	PROPN
dpc-5918	318	4	atlanta	atlanta	PROPN
dpc-5918	318	5	,	,	PUNCT
dpc-5918	318	6	ga	ga	PROPN
dpc-5918	318	7	;	;	PUNCT
dpc-5918	318	8	2017	2017	NUM
dpc-5918	318	9	.	.	X
dpc-5918	319	1	8	8	NUM
dpc-5918	319	2	.	.	X
dpc-5918	319	3	takafuji	takafuji	PROPN
dpc-5918	319	4	t	t	PROPN
dpc-5918	319	5	,	,	PUNCT
dpc-5918	319	6	kayama	kayama	PROPN
dpc-5918	319	7	k	k	PROPN
dpc-5918	319	8	,	,	PUNCT
dpc-5918	319	9	sugimoto	sugimoto	PROPN
dpc-5918	319	10	n	n	CCONJ
dpc-5918	319	11	,	,	PUNCT
dpc-5918	319	12	fujita	fujita	PROPN
dpc-5918	319	13	m.	m.	PROPN
dpc-5918	319	14	grwd1	grwd1	PROPN
dpc-5918	319	15	,	,	PUNCT
dpc-5918	319	16	a	a	DET
dpc-5918	319	17	new	new	ADJ
dpc-5918	319	18	player	player	NOUN
dpc-5918	319	19	among	among	ADP
dpc-5918	319	20	oncogenesis	oncogenesis	NOUN
dpc-5918	319	21	-	-	PUNCT
dpc-5918	319	22	related	relate	VERB
dpc-5918	319	23	ribosomal	ribosomal	NOUN
dpc-5918	319	24	/	/	SYM
dpc-5918	319	25	nucleolar	nucleolar	ADJ
dpc-5918	319	26	proteins	protein	NOUN
dpc-5918	319	27	.	.	PUNCT
dpc-5918	320	1	cell	cell	NOUN
dpc-5918	320	2	cycle	cycle	NOUN
dpc-5918	320	3	.	.	PUNCT
dpc-5918	321	1	2017;16(15):1397	2017;16(15):1397	NUM
dpc-5918	321	2	-	-	SYM
dpc-5918	321	3	1403	1403	NUM
dpc-5918	321	4	.	.	PUNCT
dpc-5918	322	1	doi	doi	NOUN
dpc-5918	322	2	:	:	PUNCT
dpc-5918	322	3	10.1080/15384101.2017.1338987	10.1080/15384101.2017.1338987	NUM
dpc-5918	322	4	.	.	X
dpc-5918	323	1	epub	epub	NOUN
dpc-5918	323	2	2017	2017	NUM
dpc-5918	323	3	jul	jul	PROPN
dpc-5918	323	4	19	19	NUM
dpc-5918	323	5	.	.	PUNCT
dpc-5918	324	1	pmid	pmid	NOUN
dpc-5918	324	2	:	:	PUNCT
dpc-5918	324	3	28722511	28722511	NUM
dpc-5918	324	4	;	;	PUNCT
dpc-5918	324	5	pmcid	pmcid	ADJ
dpc-5918	324	6	:	:	PUNCT
dpc-5918	324	7	pmc5553401	pmc5553401	NOUN
dpc-5918	324	8	.	.	PUNCT
dpc-5918	325	1	9	9	X
dpc-5918	325	2	.	.	X
dpc-5918	325	3	kayama	kayama	PROPN
dpc-5918	325	4	k	k	PROPN
dpc-5918	325	5	,	,	PUNCT
dpc-5918	325	6	watanabe	watanabe	PROPN
dpc-5918	325	7	s	s	PROPN
dpc-5918	325	8	,	,	PUNCT
dpc-5918	325	9	takafuji	takafuji	PROPN
dpc-5918	325	10	t	t	PROPN
dpc-5918	325	11	,	,	PUNCT
dpc-5918	325	12	et	et	PROPN
dpc-5918	325	13	al	al	PROPN
dpc-5918	325	14	.	.	PUNCT
dpc-5918	325	15	grwd1	grwd1	PROPN
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dpc-5918	325	17	regulates	regulate	VERB
dpc-5918	325	18	p53	p53	NOUN
dpc-5918	325	19	via	via	ADP
dpc-5918	325	20	the	the	DET
dpc-5918	325	21	rpl11	rpl11	NOUN
dpc-5918	325	22	-	-	PUNCT
dpc-5918	325	23	mdm2	mdm2	NOUN
dpc-5918	325	24	pathway	pathway	NOUN
dpc-5918	325	25	and	and	CCONJ
dpc-5918	325	26	promotes	promote	VERB
dpc-5918	325	27	tumorigenesis	tumorigenesis	NOUN
dpc-5918	325	28	.	.	PUNCT
dpc-5918	326	1	embo	embo	PROPN
dpc-5918	326	2	rep	rep	PROPN
dpc-5918	326	3	.	.	PROPN
dpc-5918	326	4	2017;18(1):123	2017;18(1):123	PROPN
dpc-5918	326	5	-	-	PUNCT
dpc-5918	326	6	137	137	NUM
dpc-5918	326	7	.	.	PUNCT
dpc-5918	327	1	doi	doi	NOUN
dpc-5918	327	2	:	:	PUNCT
dpc-5918	327	3	10.15252	10.15252	NUM
dpc-5918	327	4	/embr.201642444	/embr.201642444	PUNCT
dpc-5918	327	5	.	.	PUNCT
dpc-5918	328	1	epub	epub	PROPN
dpc-5918	328	2	2016	2016	NUM
dpc-5918	328	3	nov	nov	PROPN
dpc-5918	328	4	17	17	NUM
dpc-5918	328	5	.	.	PUNCT
dpc-5918	329	1	pmid	pmid	NOUN
dpc-5918	329	2	:	:	PUNCT
dpc-5918	329	3	27856536	27856536	NUM
dpc-5918	329	4	;	;	PUNCT
dpc-5918	329	5	pmcid	pmcid	NOUN
dpc-5918	329	6	:	:	PUNCT
dpc-5918	329	7	pmc5210153	pmc5210153	ADJ
dpc-5918	329	8	.	.	PUNCT
dpc-5918	330	1	10	10	X
dpc-5918	330	2	.	.	X
dpc-5918	330	3	fujiyama	fujiyama	PROPN
dpc-5918	330	4	h	h	PROPN
dpc-5918	330	5	,	,	PUNCT
dpc-5918	330	6	tsuji	tsuji	PROPN
dpc-5918	330	7	t	t	PROPN
dpc-5918	330	8	,	,	PUNCT
dpc-5918	330	9	hironaka	hironaka	ADV
dpc-5918	330	10	k	k	PROPN
dpc-5918	330	11	,	,	PUNCT
dpc-5918	330	12	yoshida	yoshida	PROPN
dpc-5918	330	13	k	k	PROPN
dpc-5918	330	14	,	,	PUNCT
dpc-5918	330	15	sugimoto	sugimoto	PROPN
dpc-5918	330	16	n	n	CCONJ
dpc-5918	330	17	,	,	PUNCT
dpc-5918	330	18	fujita	fujita	PROPN
dpc-5918	330	19	m.	m.	PROPN
dpc-5918	330	20	grwd1	grwd1	PROPN
dpc-5918	330	21	directly	directly	ADV
dpc-5918	330	22	interacts	interact	VERB
dpc-5918	330	23	with	with	ADP
dpc-5918	330	24	p53	p53	NOUN
dpc-5918	330	25	and	and	CCONJ
dpc-5918	330	26	negatively	negatively	ADV
dpc-5918	330	27	regulates	regulate	VERB
dpc-5918	330	28	p53	p53	NOUN
dpc-5918	330	29	transcriptional	transcriptional	NOUN
dpc-5918	330	30	activity	activity	NOUN
dpc-5918	330	31	.	.	PUNCT
dpc-5918	331	1	j	j	PROPN
dpc-5918	331	2	biochem	biochem	PROPN
dpc-5918	331	3	.	.	PUNCT
dpc-5918	332	1	2020;167(1	2020;167(1	NUM
dpc-5918	332	2	):	):	PUNCT
dpc-5918	332	3	15	15	NUM
dpc-5918	332	4	-	-	SYM
dpc-5918	332	5	24	24	NUM
dpc-5918	332	6	.	.	PUNCT
dpc-5918	333	1	doi	doi	NOUN
dpc-5918	333	2	:	:	PUNCT
dpc-5918	333	3	10.1093	10.1093	NUM
dpc-5918	333	4	/	/	SYM
dpc-5918	333	5	jb	jb	PROPN
dpc-5918	333	6	/	/	SYM
dpc-5918	333	7	mvz075	mvz075	PROPN
dpc-5918	333	8	.	.	PUNCT
dpc-5918	334	1	pmid	pmid	NOUN
dpc-5918	334	2	:	:	PUNCT
dpc-5918	334	3	31545368	31545368	NUM
dpc-5918	334	4	.	.	PUNCT
dpc-5918	335	1	11	11	NUM
dpc-5918	335	2	.	.	PUNCT
dpc-5918	336	1	özdem	özdem	PROPN
dpc-5918	336	2	b	b	PROPN
dpc-5918	336	3	,	,	PUNCT
dpc-5918	336	4	yıldırım	yıldırım	PROPN
dpc-5918	336	5	i	i	PRON
dpc-5918	336	6	,	,	PUNCT
dpc-5918	336	7	kılınçlı	kılınçlı	VERB
dpc-5918	336	8	çetin	çetin	NOUN
dpc-5918	336	9	a	a	PRON
dpc-5918	336	10	,	,	PUNCT
dpc-5918	336	11	tekedereli	tekedereli	NUM
dpc-5918	336	12	i̇.	i̇.	NOUN
dpc-5918	336	13	cynarine	cynarine	NOUN
dpc-5918	336	14	exhibits	exhibit	VERB
dpc-5918	336	15	antiproliferative	antiproliferative	ADJ
dpc-5918	336	16	activity	activity	NOUN
dpc-5918	336	17	and	and	CCONJ
dpc-5918	336	18	bcl-2	bcl-2	VERB
dpc-5918	336	19	-	-	ADJ
dpc-5918	336	20	mediated	mediate	VERB
dpc-5918	336	21	apoptotic	apoptotic	ADJ
dpc-5918	336	22	cell	cell	NOUN
dpc-5918	336	23	death	death	NOUN
dpc-5918	336	24	in	in	ADP
dpc-5918	336	25	breast	breast	NOUN
dpc-5918	336	26	cancer	cancer	NOUN
dpc-5918	336	27	cells	cell	NOUN
dpc-5918	336	28	.	.	PUNCT
dpc-5918	337	1	pharmaceutical	pharmaceutical	ADJ
dpc-5918	337	2	chemistry	chemistry	NOUN
dpc-5918	337	3	journal	journal	NOUN
dpc-5918	337	4	.	.	PUNCT
dpc-5918	338	1	2024:1	2024:1	NUM
dpc-5918	338	2	-	-	SYM
dpc-5918	338	3	5	5	NUM
dpc-5918	338	4	.	.	PUNCT
dpc-5918	338	5	doi:10.1007	doi:10.1007	VERB
dpc-5918	338	6	/	/	SYM
dpc-5918	338	7	s11094	s11094	NOUN
dpc-5918	338	8	-	-	PUNCT
dpc-5918	338	9	024	024	NUM
dpc-5918	338	10	-	-	PUNCT
dpc-5918	338	11	03229	03229	NUM
dpc-5918	338	12	-	-	PUNCT
dpc-5918	338	13	4	4	NUM
dpc-5918	338	14	.	.	NOUN
dpc-5918	338	15	12	12	NUM
dpc-5918	338	16	.	.	PUNCT
dpc-5918	339	1	tekedereli	tekedereli	VERB
dpc-5918	340	1	i	i	PRON
dpc-5918	340	2	,	,	PUNCT
dpc-5918	340	3	akar	akar	PROPN
dpc-5918	340	4	u	u	PROPN
dpc-5918	340	5	,	,	PUNCT
dpc-5918	340	6	alpay	alpay	PROPN
dpc-5918	340	7	sn	sn	PROPN
dpc-5918	340	8	,	,	PUNCT
dpc-5918	340	9	lopez	lopez	NOUN
dpc-5918	340	10	-	-	PUNCT
dpc-5918	340	11	berestein	berestein	NOUN
dpc-5918	340	12	g	g	PROPN
dpc-5918	340	13	,	,	PUNCT
dpc-5918	340	14	ozpolat	ozpolat	PROPN
dpc-5918	340	15	b.	b.	PROPN
dpc-5918	340	16	autophagy	autophagy	PROPN
dpc-5918	340	17	is	be	AUX
dpc-5918	340	18	required	require	VERB
dpc-5918	340	19	to	to	PART
dpc-5918	340	20	regulate	regulate	VERB
dpc-5918	340	21	mitochondria	mitochondria	PROPN
dpc-5918	340	22	renewal	renewal	PROPN
dpc-5918	340	23	,	,	PUNCT
dpc-5918	340	24	cell	cell	NOUN
dpc-5918	340	25	attachment	attachment	NOUN
dpc-5918	340	26	,	,	PUNCT
dpc-5918	340	27	and	and	CCONJ
dpc-5918	340	28	all	all	DET
dpc-5918	340	29	-	-	PUNCT
dpc-5918	340	30	trans	trans	ADJ
dpc-5918	340	31	-	-	ADJ
dpc-5918	340	32	retinoic	retinoic	ADJ
dpc-5918	340	33	acid	acid	NOUN
dpc-5918	340	34	-	-	PUNCT
dpc-5918	340	35	induced	induce	VERB
dpc-5918	340	36	differentiation	differentiation	NOUN
dpc-5918	340	37	in	in	ADP
dpc-5918	340	38	nb4	nb4	PROPN
dpc-5918	340	39	acute	acute	PROPN
dpc-5918	340	40	promyelocytic	promyelocytic	ADJ
dpc-5918	340	41	leukemia	leukemia	NOUN
dpc-5918	340	42	cells	cell	NOUN
dpc-5918	340	43	.	.	PUNCT
dpc-5918	341	1	j	j	PROPN
dpc-5918	341	2	environ	environ	PROPN
dpc-5918	341	3	pathol	pathol	PROPN
dpc-5918	341	4	toxicol	toxicol	PROPN
dpc-5918	341	5	oncol	oncol	ADJ
dpc-5918	341	6	.	.	PUNCT
dpc-5918	342	1	2019;38(1):13	2019;38(1):13	NUM
dpc-5918	342	2	-	-	SYM
dpc-5918	342	3	20	20	NUM
dpc-5918	342	4	.	.	PUNCT
dpc-5918	342	5	doi	doi	NOUN
dpc-5918	342	6	:	:	PUNCT
dpc-5918	342	7	10.1615	10.1615	NUM
dpc-5918	342	8	/	/	SYM
dpc-5918	342	9	jenvironpatholtoxicoloncol.2018027885	jenvironpatholtoxicoloncol.2018027885	PROPN
dpc-5918	342	10	.	.	PUNCT
dpc-5918	343	1	pmid	pmid	NOUN
dpc-5918	343	2	:	:	PUNCT
dpc-5918	343	3	30806286	30806286	NUM
dpc-5918	343	4	.	.	PUNCT
dpc-5918	344	1	13	13	NUM
dpc-5918	344	2	.	.	PUNCT
dpc-5918	345	1	wang	wang	PROPN
dpc-5918	345	2	q	q	PROPN
dpc-5918	345	3	,	,	PUNCT
dpc-5918	345	4	ren	ren	PROPN
dpc-5918	345	5	h	h	NOUN
dpc-5918	345	6	,	,	PUNCT
dpc-5918	345	7	xu	xu	PROPN
dpc-5918	345	8	y	y	PROPN
dpc-5918	345	9	,	,	PUNCT
dpc-5918	345	10	et	et	PROPN
dpc-5918	345	11	al	al	PROPN
dpc-5918	345	12	.	.	PUNCT
dpc-5918	346	1	grwd1	grwd1	PROPN
dpc-5918	346	2	promotes	promote	VERB
dpc-5918	346	3	cell	cell	NOUN
dpc-5918	346	4	proliferation	proliferation	NOUN
dpc-5918	346	5	and	and	CCONJ
dpc-5918	346	6	migration	migration	NOUN
dpc-5918	346	7	in	in	ADP
dpc-5918	346	8	non	non	ADJ
dpc-5918	346	9	-	-	ADJ
dpc-5918	346	10	small	small	ADJ
dpc-5918	346	11	cell	cell	NOUN
dpc-5918	346	12	lung	lung	NOUN
dpc-5918	346	13	cancer	cancer	NOUN
dpc-5918	346	14	by	by	ADP
dpc-5918	346	15	activating	activate	VERB
dpc-5918	346	16	the	the	DET
dpc-5918	346	17	notch	notch	ADJ
dpc-5918	346	18	pathway	pathway	NOUN
dpc-5918	346	19	.	.	PUNCT
dpc-5918	347	1	exp	exp	NOUN
dpc-5918	347	2	cell	cell	NOUN
dpc-5918	347	3	res	re	NOUN
dpc-5918	347	4	.	.	PUNCT
dpc-5918	348	1	2020;387(2):111806	2020;387(2):111806	X
dpc-5918	348	2	.	.	PUNCT
dpc-5918	348	3	doi	doi	PROPN
dpc-5918	348	4	:	:	PUNCT
dpc-5918	348	5	10.1016	10.1016	NUM
dpc-5918	348	6	/j.yexcr.2019.111806	/j.yexcr.2019.111806	X
dpc-5918	348	7	.	.	PUNCT
dpc-5918	349	1	epub	epub	PROPN
dpc-5918	349	2	2019	2019	NUM
dpc-5918	349	3	dec	dec	PROPN
dpc-5918	349	4	28	28	NUM
dpc-5918	349	5	.	.	PUNCT
dpc-5918	350	1	pmid	pmid	NOUN
dpc-5918	350	2	:	:	PUNCT
dpc-5918	350	3	31891681	31891681	NUM
dpc-5918	350	4	.	.	PUNCT
dpc-5918	351	1	14	14	NUM
dpc-5918	351	2	.	.	PUNCT
dpc-5918	352	1	yao	yao	PROPN
dpc-5918	352	2	l	l	PROPN
dpc-5918	352	3	,	,	PUNCT
dpc-5918	352	4	tian	tian	PROPN
dpc-5918	352	5	f.	f.	PROPN
dpc-5918	352	6	grwd1	grwd1	PROPN
dpc-5918	352	7	affects	affect	VERB
dpc-5918	352	8	the	the	DET
dpc-5918	352	9	proliferation	proliferation	NOUN
dpc-5918	352	10	,	,	PUNCT
dpc-5918	352	11	apoptosis	apoptosis	NOUN
dpc-5918	352	12	,	,	PUNCT
dpc-5918	352	13	invasion	invasion	NOUN
dpc-5918	352	14	and	and	CCONJ
dpc-5918	352	15	migration	migration	NOUN
dpc-5918	352	16	of	of	ADP
dpc-5918	352	17	triple	triple	ADJ
dpc-5918	352	18	negative	negative	ADJ
dpc-5918	352	19	breast	breast	NOUN
dpc-5918	352	20	cancer	cancer	NOUN
dpc-5918	352	21	through	through	ADP
dpc-5918	352	22	the	the	DET
dpc-5918	352	23	notch	notch	ADJ
dpc-5918	352	24	signaling	signal	VERB
dpc-5918	352	25	pathway	pathway	NOUN
dpc-5918	352	26	.	.	PUNCT
dpc-5918	353	1	exp	exp	NOUN
dpc-5918	353	2	ther	ther	PROPN
dpc-5918	353	3	med	med	PROPN
dpc-5918	353	4	.	.	PUNCT
dpc-5918	354	1	2022;24(1):473	2022;24(1):473	PROPN
dpc-5918	354	2	.	.	PUNCT
dpc-5918	355	1	doi	doi	NOUN
dpc-5918	355	2	:	:	PUNCT
dpc-5918	355	3	10.3892	10.3892	NUM
dpc-5918	355	4	/	/	SYM
dpc-5918	355	5	etm.2022.11400	etm.2022.11400	NOUN
dpc-5918	355	6	.	.	PUNCT
dpc-5918	356	1	pmid	pmid	NOUN
dpc-5918	356	2	:	:	PUNCT
dpc-5918	356	3	35761807	35761807	NUM
dpc-5918	356	4	;	;	PUNCT
dpc-5918	356	5	pmcid	pmcid	NOUN
dpc-5918	356	6	:	:	PUNCT
dpc-5918	356	7	pmc9214606	pmc9214606	ADJ
dpc-5918	356	8	.	.	PUNCT
dpc-5918	357	1	15	15	NUM
dpc-5918	357	2	.	.	X
dpc-5918	357	3	ding	ding	PROPN
dpc-5918	357	4	h	h	PROPN
dpc-5918	357	5	,	,	PUNCT
dpc-5918	357	6	feng	feng	PROPN
dpc-5918	357	7	z	z	PROPN
dpc-5918	357	8	,	,	PUNCT
dpc-5918	357	9	hu	hu	PROPN
dpc-5918	357	10	k.	k.	PROPN
dpc-5918	357	11	grwd1	grwd1	PROPN
dpc-5918	357	12	over	over	ADP
dpc-5918	357	13	-	-	PUNCT
dpc-5918	357	14	expression	expression	NOUN
dpc-5918	357	15	promotes	promote	VERB
dpc-5918	357	16	gastric	gastric	ADJ
dpc-5918	357	17	cancer	cancer	NOUN
dpc-5918	357	18	progression	progression	NOUN
dpc-5918	357	19	by	by	ADP
dpc-5918	357	20	activating	activate	VERB
dpc-5918	357	21	notch	notch	NOUN
dpc-5918	357	22	signaling	signal	VERB
dpc-5918	357	23	pathway	pathway	NOUN
dpc-5918	357	24	via	via	ADP
dpc-5918	357	25	up	up	ADP
dpc-5918	357	26	-	-	PUNCT
dpc-5918	357	27	regulation	regulation	NOUN
dpc-5918	357	28	of	of	ADP
dpc-5918	357	29	adam17	adam17	NOUN
dpc-5918	357	30	.	.	PUNCT
dpc-5918	358	1	dig	dig	VERB
dpc-5918	358	2	dis	dis	PROPN
dpc-5918	358	3	sci	sci	PROPN
dpc-5918	358	4	.	.	PROPN
dpc-5918	359	1	regarding	regard	VERB
dpc-5918	359	2	its	its	PRON
dpc-5918	359	3	role	role	NOUN
dpc-5918	359	4	in	in	ADP
dpc-5918	359	5	a	a	DET
dpc-5918	359	6	variety	variety	NOUN
dpc-5918	359	7	of	of	ADP
dpc-5918	359	8	malignancies	malignancy	NOUN
dpc-5918	359	9	,	,	PUNCT
dpc-5918	359	10	zhou	zhou	PROPN
dpc-5918	359	11	and	and	CCONJ
dpc-5918	359	12	shang	shang	PROPN
dpc-5918	359	13	[	[	X
dpc-5918	359	14	16	16	NUM
dpc-5918	359	15	]	]	PUNCT
dpc-5918	359	16	concluded	conclude	VERB
dpc-5918	359	17	that	that	SCONJ
dpc-5918	359	18	grwd1	grwd1	ADJ
dpc-5918	359	19	overexpression	overexpression	NOUN
dpc-5918	359	20	is	be	AUX
dpc-5918	359	21	linked	link	VERB
dpc-5918	359	22	to	to	ADP
dpc-5918	359	23	poor	poor	ADJ
dpc-5918	359	24	clinical	clinical	ADJ
dpc-5918	359	25	outcomes	outcome	NOUN
dpc-5918	359	26	in	in	ADP
dpc-5918	359	27	colorectal	colorectal	ADJ
dpc-5918	359	28	cancer	cancer	NOUN
dpc-5918	359	29	.	.	PUNCT
dpc-5918	360	1	in	in	ADP
dpc-5918	360	2	contrast	contrast	NOUN
dpc-5918	360	3	,	,	PUNCT
dpc-5918	360	4	in	in	ADP
dpc-5918	360	5	our	our	PRON
dpc-5918	360	6	immunohistochemical	immunohistochemical	ADJ
dpc-5918	360	7	analyses	analysis	NOUN
dpc-5918	360	8	conducted	conduct	VERB
dpc-5918	360	9	with	with	ADP
dpc-5918	360	10	clinical	clinical	ADJ
dpc-5918	360	11	data	datum	NOUN
dpc-5918	360	12	,	,	PUNCT
dpc-5918	360	13	the	the	DET
dpc-5918	360	14	lack	lack	NOUN
dpc-5918	360	15	of	of	ADP
dpc-5918	360	16	statistical	statistical	ADJ
dpc-5918	360	17	significance	significance	NOUN
dpc-5918	360	18	in	in	ADP
dpc-5918	360	19	the	the	DET
dpc-5918	360	20	relationship	relationship	NOUN
dpc-5918	360	21	between	between	ADP
dpc-5918	360	22	grwd1	grwd1	NOUN
dpc-5918	360	23	expression	expression	NOUN
dpc-5918	360	24	and	and	CCONJ
dpc-5918	360	25	survival	survival	NOUN
dpc-5918	360	26	is	be	AUX
dpc-5918	360	27	likely	likely	ADJ
dpc-5918	360	28	due	due	ADP
dpc-5918	360	29	to	to	ADP
dpc-5918	360	30	the	the	DET
dpc-5918	360	31	limited	limited	ADJ
dpc-5918	360	32	sample	sample	NOUN
dpc-5918	360	33	size	size	NOUN
dpc-5918	360	34	in	in	ADP
dpc-5918	360	35	our	our	PRON
dpc-5918	360	36	local	local	ADJ
dpc-5918	360	37	cohort	cohort	NOUN
dpc-5918	360	38	.	.	PUNCT
dpc-5918	361	1	therefore	therefore	ADV
dpc-5918	361	2	,	,	PUNCT
dpc-5918	361	3	while	while	SCONJ
dpc-5918	361	4	tcga	tcga	PROPN
dpc-5918	361	5	data	datum	NOUN
dpc-5918	361	6	suggest	suggest	VERB
dpc-5918	361	7	grwd1	grwd1	NOUN
dpc-5918	361	8	may	may	AUX
dpc-5918	361	9	serve	serve	VERB
dpc-5918	361	10	as	as	ADP
dpc-5918	361	11	a	a	DET
dpc-5918	361	12	potential	potential	ADJ
dpc-5918	361	13	prognostic	prognostic	ADJ
dpc-5918	361	14	marker	marker	NOUN
dpc-5918	361	15	,	,	PUNCT
dpc-5918	361	16	further	further	ADJ
dpc-5918	361	17	validation	validation	NOUN
dpc-5918	361	18	in	in	ADP
dpc-5918	361	19	larger	large	ADJ
dpc-5918	361	20	,	,	PUNCT
dpc-5918	361	21	independent	independent	ADJ
dpc-5918	361	22	patient	patient	NOUN
dpc-5918	361	23	cohorts	cohort	NOUN
dpc-5918	361	24	is	be	AUX
dpc-5918	361	25	required	require	VERB
dpc-5918	361	26	to	to	PART
dpc-5918	361	27	confirm	confirm	VERB
dpc-5918	361	28	its	its	PRON
dpc-5918	361	29	clinical	clinical	ADJ
dpc-5918	361	30	relevance	relevance	NOUN
dpc-5918	361	31	and	and	CCONJ
dpc-5918	361	32	accuracy	accuracy	NOUN
dpc-5918	361	33	.	.	PUNCT
dpc-5918	362	1	we	we	PRON
dpc-5918	362	2	acknowledge	acknowledge	VERB
dpc-5918	362	3	the	the	DET
dpc-5918	362	4	limitations	limitation	NOUN
dpc-5918	362	5	of	of	ADP
dpc-5918	362	6	our	our	PRON
dpc-5918	362	7	current	current	ADJ
dpc-5918	362	8	sample	sample	NOUN
dpc-5918	362	9	and	and	CCONJ
dpc-5918	362	10	emphasize	emphasize	VERB
dpc-5918	362	11	the	the	DET
dpc-5918	362	12	need	need	NOUN
dpc-5918	362	13	for	for	ADP
dpc-5918	362	14	future	future	ADJ
dpc-5918	362	15	studies	study	NOUN
dpc-5918	362	16	with	with	ADP
dpc-5918	362	17	greater	great	ADJ
dpc-5918	362	18	statistical	statistical	ADJ
dpc-5918	362	19	power	power	NOUN
dpc-5918	362	20	.	.	PUNCT
dpc-5918	363	1	conclusion	conclusion	NOUN
dpc-5918	363	2	our	our	PRON
dpc-5918	363	3	results	result	NOUN
dpc-5918	363	4	suggest	suggest	VERB
dpc-5918	363	5	that	that	SCONJ
dpc-5918	363	6	grwd1	grwd1	NOUN
dpc-5918	363	7	supports	support	VERB
dpc-5918	363	8	melanoma	melanoma	NOUN
dpc-5918	363	9	progression	progression	NOUN
dpc-5918	363	10	through	through	ADP
dpc-5918	363	11	the	the	DET
dpc-5918	363	12	nf	nf	ADJ
dpc-5918	363	13	-	-	PUNCT
dpc-5918	363	14	κb	κb	NOUN
dpc-5918	363	15	pathway	pathway	NOUN
dpc-5918	363	16	regulating	regulate	VERB
dpc-5918	363	17	mdm2	mdm2	PROPN
dpc-5918	363	18	-	-	PUNCT
dpc-5918	363	19	p53	p53	PROPN
dpc-5918	363	20	,	,	PUNCT
dpc-5918	363	21	src	src	NOUN
dpc-5918	363	22	,	,	PUNCT
dpc-5918	363	23	bcl-2	bcl-2	PUNCT
dpc-5918	363	24	expressions	expression	NOUN
dpc-5918	363	25	(	(	PUNCT
dpc-5918	363	26	figure	figure	NOUN
dpc-5918	363	27	5	5	NUM
dpc-5918	363	28	)	)	PUNCT
dpc-5918	363	29	.	.	PUNCT
dpc-5918	364	1	therefore	therefore	ADV
dpc-5918	364	2	,	,	PUNCT
dpc-5918	364	3	targeting	target	VERB
dpc-5918	364	4	grwd1	grwd1	NOUN
dpc-5918	364	5	holds	hold	VERB
dpc-5918	364	6	promise	promise	NOUN
dpc-5918	364	7	for	for	ADP
dpc-5918	364	8	melanoma	melanoma	NOUN
dpc-5918	364	9	treatment	treatment	NOUN
dpc-5918	364	10	.	.	PUNCT
dpc-5918	365	1	however	however	ADV
dpc-5918	365	2	,	,	PUNCT
dpc-5918	365	3	tumor	tumor	NOUN
dpc-5918	365	4	-	-	PUNCT
dpc-5918	365	5	specific	specific	ADJ
dpc-5918	365	6	targeting	targeting	NOUN
dpc-5918	365	7	strategies	strategy	NOUN
dpc-5918	365	8	,	,	PUNCT
dpc-5918	365	9	in	in	ADP
dpc-5918	365	10	vivo	vivo	ADJ
dpc-5918	365	11	studies	study	NOUN
dpc-5918	365	12	,	,	PUNCT
dpc-5918	365	13	and	and	CCONJ
dpc-5918	365	14	clinical	clinical	ADJ
dpc-5918	365	15	validation	validation	NOUN
dpc-5918	365	16	are	be	AUX
dpc-5918	365	17	required	require	VERB
dpc-5918	365	18	to	to	PART
dpc-5918	365	19	confirm	confirm	VERB
dpc-5918	365	20	its	its	PRON
dpc-5918	365	21	therapeutic	therapeutic	ADJ
dpc-5918	365	22	potential	potential	NOUN
dpc-5918	365	23	.	.	PUNCT
dpc-5918	366	1	references	reference	NOUN
dpc-5918	366	2	1	1	NUM
dpc-5918	366	3	.	.	PUNCT
dpc-5918	367	1	linares	linares	PROPN
dpc-5918	367	2	ma	ma	PROPN
dpc-5918	367	3	,	,	PUNCT
dpc-5918	367	4	zakaria	zakaria	PROPN
dpc-5918	367	5	a	a	PRON
dpc-5918	367	6	,	,	PUNCT
dpc-5918	367	7	nizran	nizran	ADJ
dpc-5918	367	8	p.	p.	NOUN
dpc-5918	367	9	skin	skin	NOUN
dpc-5918	367	10	cancer	cancer	NOUN
dpc-5918	367	11	.	.	PUNCT
dpc-5918	368	1	prim	prim	ADJ
dpc-5918	368	2	care	care	NOUN
dpc-5918	368	3	.	.	PUNCT
dpc-5918	369	1	2015;42(4):645	2015;42(4):645	NUM
dpc-5918	369	2	-	-	SYM
dpc-5918	369	3	59	59	NUM
dpc-5918	369	4	.	.	PUNCT
dpc-5918	370	1	doi	doi	NOUN
dpc-5918	370	2	:	:	PUNCT
dpc-5918	370	3	10.1016	10.1016	NUM
dpc-5918	370	4	/	/	SYM
dpc-5918	370	5	j.pop.2015.07.006	j.pop.2015.07.006	PROPN
dpc-5918	370	6	.	.	PUNCT
dpc-5918	371	1	pmid	pmid	NOUN
dpc-5918	371	2	:	:	PUNCT
dpc-5918	371	3	26612377	26612377	NUM
dpc-5918	371	4	.	.	PUNCT
dpc-5918	372	1	figure	figure	NOUN
dpc-5918	372	2	5	5	NUM
dpc-5918	372	3	.	.	PUNCT
dpc-5918	373	1	grwd1	grwd1	NOUN
dpc-5918	373	2	promotes	promote	VERB
dpc-5918	373	3	the	the	DET
dpc-5918	373	4	ability	ability	NOUN
dpc-5918	373	5	of	of	ADP
dpc-5918	373	6	proliferation	proliferation	NOUN
dpc-5918	373	7	,	,	PUNCT
dpc-5918	373	8	survival	survival	NOUN
dpc-5918	373	9	and	and	CCONJ
dpc-5918	373	10	invasion	invasion	NOUN
dpc-5918	373	11	in	in	ADP
dpc-5918	373	12	melanoma	melanoma	NOUN
dpc-5918	373	13	cells	cell	NOUN
dpc-5918	373	14	through	through	ADP
dpc-5918	373	15	the	the	DET
dpc-5918	373	16	activation	activation	NOUN
dpc-5918	373	17	of	of	ADP
dpc-5918	373	18	nf	nf	ADJ
dpc-5918	373	19	-	-	PUNCT
dpc-5918	373	20	κb	κb	NOUN
dpc-5918	373	21	pathway	pathway	NOUN
dpc-5918	373	22	.	.	PUNCT
dpc-5918	374	1	proposed	propose	VERB
dpc-5918	374	2	mechanism	mechanism	NOUN
dpc-5918	374	3	underlying	underlie	VERB
dpc-5918	374	4	grwd1	grwd1	ADV
dpc-5918	374	5	-	-	PUNCT
dpc-5918	374	6	mediated	mediate	VERB
dpc-5918	374	7	melanoma	melanoma	NOUN
dpc-5918	374	8	progression	progression	NOUN
dpc-5918	374	9	.	.	PUNCT
dpc-5918	375	1	grwd1	grwd1	NOUN
dpc-5918	375	2	enhances	enhance	VERB
dpc-5918	375	3	nf	nf	ADJ
dpc-5918	375	4	-	-	PUNCT
dpc-5918	375	5	κb	κb	NOUN
dpc-5918	375	6	signaling	signaling	NOUN
dpc-5918	375	7	,	,	PUNCT
dpc-5918	375	8	which	which	PRON
dpc-5918	375	9	transcriptionally	transcriptionally	ADV
dpc-5918	375	10	upregulates	upregulate	VERB
dpc-5918	375	11	bcl-2	bcl-2	PUNCT
dpc-5918	375	12	and	and	CCONJ
dpc-5918	375	13	activates	activate	VERB
dpc-5918	375	14	src	src	PROPN
dpc-5918	375	15	.	.	PUNCT
dpc-5918	376	1	nf	nf	PROPN
dpc-5918	376	2	-	-	PUNCT
dpc-5918	376	3	κb	κb	PROPN
dpc-5918	376	4	also	also	ADV
dpc-5918	376	5	induces	induce	VERB
dpc-5918	376	6	mdm2	mdm2	NOUN
dpc-5918	376	7	expression	expression	NOUN
dpc-5918	376	8	,	,	PUNCT
dpc-5918	376	9	promoting	promote	VERB
dpc-5918	376	10	p53	p53	NOUN
dpc-5918	376	11	degradation	degradation	NOUN
dpc-5918	376	12	.	.	PUNCT
dpc-5918	377	1	the	the	DET
dpc-5918	377	2	downregulation	downregulation	NOUN
dpc-5918	377	3	of	of	ADP
dpc-5918	377	4	p53	p53	NOUN
dpc-5918	377	5	relieves	relieve	VERB
dpc-5918	377	6	transcriptional	transcriptional	ADJ
dpc-5918	377	7	repression	repression	NOUN
dpc-5918	377	8	of	of	ADP
dpc-5918	377	9	bcl-2	bcl-2	NOUN
dpc-5918	377	10	,	,	PUNCT
dpc-5918	377	11	further	far	ADV
dpc-5918	377	12	supporting	support	VERB
dpc-5918	377	13	cell	cell	NOUN
dpc-5918	377	14	survival	survival	NOUN
dpc-5918	377	15	and	and	CCONJ
dpc-5918	377	16	proliferation	proliferation	NOUN
dpc-5918	377	17	.	.	PUNCT
dpc-5918	378	1	this	this	DET
dpc-5918	378	2	grwd1	grwd1	ADJ
dpc-5918	378	3	–	–	PUNCT
dpc-5918	378	4	nf	nf	NOUN
dpc-5918	378	5	-	-	PUNCT
dpc-5918	378	6	κb	κb	NOUN
dpc-5918	378	7	–	–	PUNCT
dpc-5918	378	8	mdm2	mdm2	PROPN
dpc-5918	378	9	/	/	SYM
dpc-5918	378	10	p53	p53	PROPN
dpc-5918	378	11	–	–	PUNCT
dpc-5918	378	12	bcl-2	bcl-2	VERB
dpc-5918	378	13	axis	axis	NOUN
dpc-5918	378	14	contributes	contribute	VERB
dpc-5918	378	15	to	to	ADP
dpc-5918	378	16	melanoma	melanoma	NOUN
dpc-5918	378	17	pathogenesis	pathogenesis	NOUN
dpc-5918	378	18	.	.	PUNCT
dpc-5918	379	1	arrows	arrow	NOUN
dpc-5918	379	2	represent	represent	VERB
dpc-5918	379	3	activation	activation	NOUN
dpc-5918	379	4	(	(	PUNCT
dpc-5918	379	5	solid	solid	ADJ
dpc-5918	379	6	)	)	PUNCT
dpc-5918	379	7	and	and	CCONJ
dpc-5918	379	8	inhibition	inhibition	NOUN
dpc-5918	379	9	(	(	PUNCT
dpc-5918	379	10	dashed	dash	VERB
dpc-5918	379	11	)	)	PUNCT
dpc-5918	379	12	.	.	PUNCT
dpc-5918	380	1	10	10	NUM
dpc-5918	380	2	original	original	ADJ
dpc-5918	380	3	article	article	NOUN
dpc-5918	380	4	|	|	ADV
dpc-5918	380	5	dermatol	dermatol	ADJ
dpc-5918	380	6	pract	pract	NOUN
dpc-5918	380	7	concept	concept	NOUN
dpc-5918	380	8	.	.	PUNCT
dpc-5918	381	1	2025;15(4):5918	2025;15(4):5918	NUM
dpc-5918	381	2	/mbio.03431	/mbio.03431	PUNCT
dpc-5918	381	3	-	-	PUNCT
dpc-5918	381	4	21	21	NUM
dpc-5918	381	5	.	.	PUNCT
dpc-5918	382	1	epub	epub	NOUN
dpc-5918	382	2	2021	2021	NUM
dpc-5918	382	3	dec	dec	PROPN
dpc-5918	382	4	21	21	NUM
dpc-5918	382	5	.	.	PUNCT
dpc-5918	383	1	pmid	pmid	NOUN
dpc-5918	383	2	:	:	PUNCT
dpc-5918	383	3	34933446	34933446	NUM
dpc-5918	383	4	;	;	PUNCT
dpc-5918	383	5	pmcid	pmcid	ADJ
dpc-5918	383	6	:	:	PUNCT
dpc-5918	383	7	pmc8689518	pmc8689518	ADJ
dpc-5918	383	8	.	.	PUNCT
dpc-5918	384	1	19	19	NUM
dpc-5918	384	2	.	.	PUNCT
dpc-5918	385	1	kayama	kayama	PROPN
dpc-5918	385	2	k	k	PROPN
dpc-5918	385	3	,	,	PUNCT
dpc-5918	385	4	ooga	ooga	VERB
dpc-5918	385	5	a	a	PRON
dpc-5918	385	6	,	,	PUNCT
dpc-5918	385	7	hasetsu	hasetsu	PROPN
dpc-5918	385	8	k	k	NOUN
dpc-5918	385	9	,	,	PUNCT
dpc-5918	385	10	kokubo	kokubo	PROPN
dpc-5918	385	11	r	r	PROPN
dpc-5918	385	12	,	,	PUNCT
dpc-5918	385	13	sugimoto	sugimoto	PROPN
dpc-5918	385	14	n	n	CCONJ
dpc-5918	385	15	,	,	PUNCT
dpc-5918	385	16	fujita	fujita	PROPN
dpc-5918	385	17	m.	m.	PROPN
dpc-5918	385	18	high	high	ADJ
dpc-5918	385	19	grwd1	grwd1	NOUN
dpc-5918	385	20	expression	expression	NOUN
dpc-5918	385	21	may	may	AUX
dpc-5918	385	22	predict	predict	VERB
dpc-5918	385	23	clinically	clinically	ADV
dpc-5918	385	24	aggressive	aggressive	ADJ
dpc-5918	385	25	lower	low	ADJ
dpc-5918	385	26	grade	grade	NOUN
dpc-5918	385	27	glioma	glioma	NOUN
dpc-5918	385	28	,	,	PUNCT
dpc-5918	385	29	skin	skin	NOUN
dpc-5918	385	30	cutaneous	cutaneous	ADJ
dpc-5918	385	31	melanoma	melanoma	NOUN
dpc-5918	385	32	,	,	PUNCT
dpc-5918	385	33	and	and	CCONJ
dpc-5918	385	34	kidney	kidney	PROPN
dpc-5918	385	35	renal	renal	ADJ
dpc-5918	385	36	clear	clear	ADJ
dpc-5918	385	37	cell	cell	NOUN
dpc-5918	385	38	carcinoma	carcinoma	NOUN
dpc-5918	385	39	carrying	carry	VERB
dpc-5918	385	40	wild	wild	ADJ
dpc-5918	385	41	-	-	PUNCT
dpc-5918	385	42	type	type	NOUN
dpc-5918	385	43	p53	p53	NOUN
dpc-5918	385	44	:	:	PUNCT
dpc-5918	385	45	a	a	DET
dpc-5918	385	46	systematic	systematic	ADJ
dpc-5918	385	47	study	study	NOUN
dpc-5918	385	48	based	base	VERB
dpc-5918	385	49	on	on	ADP
dpc-5918	385	50	tcga	tcga	PROPN
dpc-5918	385	51	data	datum	NOUN
dpc-5918	385	52	analysis	analysis	NOUN
dpc-5918	385	53	.	.	PUNCT
dpc-5918	386	1	j	j	PROPN
dpc-5918	386	2	biochem	biochem	PROPN
dpc-5918	386	3	.	.	PUNCT
dpc-5918	387	1	2025;177(5):351	2025;177(5):351	X
dpc-5918	387	2	-	-	SYM
dpc-5918	387	3	361	361	NUM
dpc-5918	387	4	.	.	PUNCT
dpc-5918	388	1	doi	doi	NOUN
dpc-5918	388	2	:	:	PUNCT
dpc-5918	388	3	10.1093	10.1093	NUM
dpc-5918	388	4	/	/	SYM
dpc-5918	388	5	jb	jb	PROPN
dpc-5918	388	6	/	/	SYM
dpc-5918	388	7	mvaf004	mvaf004	PROPN
dpc-5918	388	8	.	.	PUNCT
dpc-5918	389	1	pmid	pmid	NOUN
dpc-5918	389	2	:	:	PUNCT
dpc-5918	389	3	39812614	39812614	NUM
dpc-5918	389	4	.	.	PUNCT
dpc-5918	390	1	20	20	NUM
dpc-5918	390	2	.	.	PUNCT
dpc-5918	391	1	deng	deng	PROPN
dpc-5918	391	2	x	x	PROPN
dpc-5918	391	3	,	,	PUNCT
dpc-5918	391	4	li	li	PROPN
dpc-5918	391	5	s	s	PROPN
dpc-5918	391	6	,	,	PUNCT
dpc-5918	391	7	kong	kong	PROPN
dpc-5918	391	8	f	f	PROPN
dpc-5918	391	9	,	,	PUNCT
dpc-5918	391	10	ruan	ruan	PROPN
dpc-5918	391	11	h	h	PROPN
dpc-5918	391	12	,	,	PUNCT
dpc-5918	391	13	xu	xu	PROPN
dpc-5918	391	14	x	x	PROPN
dpc-5918	391	15	,	,	PUNCT
dpc-5918	391	16	zhang	zhang	PROPN
dpc-5918	391	17	x	x	PROPN
dpc-5918	391	18	,	,	PUNCT
dpc-5918	391	19	wu	wu	PROPN
dpc-5918	391	20	z	z	PROPN
dpc-5918	391	21	,	,	PUNCT
dpc-5918	391	22	zhang	zhang	PROPN
dpc-5918	391	23	l	l	PROPN
dpc-5918	391	24	,	,	PUNCT
dpc-5918	391	25	xu	xu	PROPN
dpc-5918	391	26	y	y	PROPN
dpc-5918	391	27	,	,	PUNCT
dpc-5918	391	28	yuan	yuan	NOUN
dpc-5918	391	29	h	h	NOUN
dpc-5918	391	30	,	,	PUNCT
dpc-5918	391	31	peng	peng	PROPN
dpc-5918	391	32	h	h	PROPN
dpc-5918	391	33	,	,	PUNCT
dpc-5918	391	34	yang	yang	PROPN
dpc-5918	391	35	d	d	PROPN
dpc-5918	391	36	,	,	PUNCT
dpc-5918	391	37	guan	guan	PROPN
dpc-5918	391	38	m.	m.	PROPN
dpc-5918	391	39	long	long	ADV
dpc-5918	391	40	noncoding	noncode	VERB
dpc-5918	391	41	rna	rna	NOUN
dpc-5918	391	42	pihl	pihl	NOUN
dpc-5918	391	43	regulates	regulate	VERB
dpc-5918	391	44	p53	p53	NOUN
dpc-5918	391	45	protein	protein	NOUN
dpc-5918	391	46	stability	stability	NOUN
dpc-5918	391	47	through	through	ADP
dpc-5918	391	48	grwd1/	grwd1/	ADJ
dpc-5918	391	49	rpl11	rpl11	NOUN
dpc-5918	391	50	/	/	SYM
dpc-5918	391	51	mdm2	mdm2	NOUN
dpc-5918	391	52	axis	axis	NOUN
dpc-5918	391	53	in	in	ADP
dpc-5918	391	54	colorectal	colorectal	ADJ
dpc-5918	391	55	cancer	cancer	NOUN
dpc-5918	391	56	.	.	PUNCT
dpc-5918	392	1	theranostics	theranostic	NOUN
dpc-5918	392	2	.	.	PUNCT
dpc-5918	393	1	2020	2020	NUM
dpc-5918	393	2	;	;	PUNCT
dpc-5918	393	3	10(1):265	10(1):265	NUM
dpc-5918	393	4	-	-	SYM
dpc-5918	393	5	280	280	NUM
dpc-5918	393	6	.	.	PUNCT
dpc-5918	394	1	doi	doi	NOUN
dpc-5918	394	2	:	:	PUNCT
dpc-5918	394	3	10.7150	10.7150	NUM
dpc-5918	394	4	/	/	SYM
dpc-5918	394	5	thno.36045	thno.36045	PROPN
dpc-5918	394	6	.	.	PUNCT
dpc-5918	394	7	pmid	pmid	PROPN
dpc-5918	394	8	:	:	PUNCT
dpc-5918	394	9	31903119	31903119	NUM
dpc-5918	394	10	;	;	PUNCT
dpc-5918	394	11	pmcid	pmcid	ADJ
dpc-5918	394	12	:	:	PUNCT
dpc-5918	394	13	pmc6929633	pmc6929633	NOUN
dpc-5918	394	14	.	.	PUNCT
dpc-5918	395	1	2024;69(3):821	2024;69(3):821	NUM
dpc-5918	395	2	-	-	PUNCT
dpc-5918	395	3	834	834	NUM
dpc-5918	395	4	.	.	PUNCT
dpc-5918	396	1	doi	doi	NOUN
dpc-5918	396	2	:	:	PUNCT
dpc-5918	396	3	10.1007	10.1007	NUM
dpc-5918	396	4	/	/	SYM
dpc-5918	396	5	s10620	s10620	PROPN
dpc-5918	396	6	-	-	PUNCT
dpc-5918	396	7	023	023	NUM
dpc-5918	396	8	-	-	PUNCT
dpc-5918	396	9	08208	08208	NUM
dpc-5918	396	10	-	-	SYM
dpc-5918	396	11	5	5	NUM
dpc-5918	396	12	.	.	PUNCT
dpc-5918	397	1	epub	epub	PROPN
dpc-5918	397	2	2024	2024	NUM
dpc-5918	397	3	jan	jan	PROPN
dpc-5918	397	4	3	3	NUM
dpc-5918	397	5	.	.	PUNCT
dpc-5918	397	6	pmid	pmid	NOUN
dpc-5918	397	7	:	:	PUNCT
dpc-5918	397	8	38172445	38172445	NUM
dpc-5918	397	9	.	.	PUNCT
dpc-5918	398	1	16	16	NUM
dpc-5918	398	2	.	.	PUNCT
dpc-5918	399	1	zhou	zhou	PROPN
dpc-5918	399	2	x	x	PROPN
dpc-5918	399	3	,	,	PUNCT
dpc-5918	399	4	shang	shang	PROPN
dpc-5918	399	5	j	j	PROPN
dpc-5918	399	6	,	,	PUNCT
dpc-5918	399	7	liu	liu	PROPN
dpc-5918	399	8	x	x	PROPN
dpc-5918	399	9	,	,	PUNCT
dpc-5918	399	10	et	et	PROPN
dpc-5918	399	11	al	al	PROPN
dpc-5918	399	12	.	.	PROPN
dpc-5918	399	13	clinical	clinical	ADJ
dpc-5918	399	14	significance	significance	NOUN
dpc-5918	399	15	and	and	CCONJ
dpc-5918	399	16	oncogenic	oncogenic	ADJ
dpc-5918	399	17	activity	activity	NOUN
dpc-5918	399	18	of	of	ADP
dpc-5918	399	19	grwd1	grwd1	ADJ
dpc-5918	399	20	overexpression	overexpression	NOUN
dpc-5918	399	21	in	in	ADP
dpc-5918	399	22	the	the	DET
dpc-5918	399	23	development	development	NOUN
dpc-5918	399	24	of	of	ADP
dpc-5918	399	25	colon	colon	NOUN
dpc-5918	399	26	carcinoma	carcinoma	NOUN
dpc-5918	399	27	.	.	PUNCT
dpc-5918	400	1	onco	onco	NOUN
dpc-5918	400	2	targets	target	NOUN
dpc-5918	400	3	ther	ther	ADV
dpc-5918	400	4	.	.	PUNCT
dpc-5918	401	1	2021;14:1565	2021;14:1565	NUM
dpc-5918	401	2	-	-	SYM
dpc-5918	401	3	1580	1580	NUM
dpc-5918	401	4	.	.	PUNCT
dpc-5918	402	1	doi	doi	NOUN
dpc-5918	402	2	:	:	PUNCT
dpc-5918	402	3	10.2147	10.2147	NUM
dpc-5918	402	4	/	/	SYM
dpc-5918	402	5	ott.s290475	ott.s290475	NOUN
dpc-5918	402	6	.	.	PUNCT
dpc-5918	403	1	pmid	pmid	NOUN
dpc-5918	403	2	:	:	PUNCT
dpc-5918	403	3	33688204	33688204	NUM
dpc-5918	403	4	;	;	PUNCT
dpc-5918	403	5	pmcid	pmcid	NOUN
dpc-5918	403	6	:	:	PUNCT
dpc-5918	403	7	pmc7936717	pmc7936717	ADJ
dpc-5918	403	8	.	.	PUNCT
dpc-5918	404	1	17	17	NUM
dpc-5918	404	2	.	.	PUNCT
dpc-5918	405	1	watanabe	watanabe	PROPN
dpc-5918	405	2	s	s	PROPN
dpc-5918	405	3	,	,	PUNCT
dpc-5918	405	4	fujiyama	fujiyama	NOUN
dpc-5918	405	5	h	h	NOUN
dpc-5918	405	6	,	,	PUNCT
dpc-5918	405	7	takafuji	takafuji	PROPN
dpc-5918	405	8	t	t	PROPN
dpc-5918	405	9	,	,	PUNCT
dpc-5918	405	10	et	et	PROPN
dpc-5918	405	11	al	al	PROPN
dpc-5918	405	12	.	.	PUNCT
dpc-5918	406	1	grwd1	grwd1	PROPN
dpc-5918	406	2	regulates	regulate	VERB
dpc-5918	406	3	ribosomal	ribosomal	NOUN
dpc-5918	406	4	protein	protein	NOUN
dpc-5918	406	5	l23	l23	NOUN
dpc-5918	406	6	levels	level	NOUN
dpc-5918	406	7	via	via	ADP
dpc-5918	406	8	the	the	DET
dpc-5918	406	9	ubiquitin	ubiquitin	ADJ
dpc-5918	406	10	-	-	PUNCT
dpc-5918	406	11	proteasome	proteasome	NOUN
dpc-5918	406	12	system	system	NOUN
dpc-5918	406	13	.	.	PUNCT
dpc-5918	407	1	j	j	PROPN
dpc-5918	407	2	cell	cell	PROPN
dpc-5918	407	3	sci	sci	PROPN
dpc-5918	407	4	.	.	PUNCT
dpc-5918	408	1	2018;131(15):jcs213009	2018;131(15):jcs213009	NUM
dpc-5918	408	2	.	.	PUNCT
dpc-5918	409	1	doi	doi	NOUN
dpc-5918	409	2	:	:	PUNCT
dpc-5918	409	3	10.1242	10.1242	NUM
dpc-5918	409	4	/	/	SYM
dpc-5918	409	5	jcs.213009	jcs.213009	PROPN
dpc-5918	409	6	.	.	PUNCT
dpc-5918	410	1	pmid	pmid	NOUN
dpc-5918	410	2	:	:	PUNCT
dpc-5918	410	3	29991511	29991511	NUM
dpc-5918	410	4	.	.	PUNCT
dpc-5918	411	1	18	18	NUM
dpc-5918	411	2	.	.	PUNCT
dpc-5918	412	1	wei	wei	PROPN
dpc-5918	412	2	s	s	PROPN
dpc-5918	412	3	,	,	PUNCT
dpc-5918	412	4	lu	lu	PROPN
dpc-5918	412	5	s	s	PROPN
dpc-5918	412	6	,	,	PUNCT
dpc-5918	412	7	liang	liang	PROPN
dpc-5918	412	8	l	l	PROPN
dpc-5918	412	9	,	,	PUNCT
dpc-5918	412	10	et	et	PROPN
dpc-5918	412	11	al	al	PROPN
dpc-5918	412	12	.	.	PUNCT
dpc-5918	413	1	grwd1	grwd1	ADJ
dpc-5918	413	2	-	-	PUNCT
dpc-5918	413	3	wdr5	wdr5	NOUN
dpc-5918	413	4	-	-	PUNCT
dpc-5918	413	5	mll2	mll2	PROPN
dpc-5918	413	6	epigenetic	epigenetic	ADJ
dpc-5918	413	7	complex	complex	ADJ
dpc-5918	413	8	mediates	mediate	NOUN
dpc-5918	413	9	h3k4me3	h3k4me3	NOUN
dpc-5918	413	10	mark	mark	NOUN
dpc-5918	413	11	and	and	CCONJ
dpc-5918	413	12	is	be	AUX
dpc-5918	413	13	essential	essential	ADJ
dpc-5918	413	14	for	for	ADP
dpc-5918	413	15	kaposi	kaposi	PROPN
dpc-5918	413	16	's	's	PART
dpc-5918	413	17	sarcoma	sarcoma	NOUN
dpc-5918	413	18	-	-	PUNCT
dpc-5918	413	19	associated	associate	VERB
dpc-5918	413	20	herpesvirus	herpesvirus	NOUN
dpc-5918	413	21	-	-	PUNCT
dpc-5918	413	22	induced	induce	VERB
dpc-5918	413	23	cellular	cellular	ADJ
dpc-5918	413	24	transformation	transformation	NOUN
dpc-5918	413	25	.	.	PUNCT
dpc-5918	414	1	mbio	mbio	PROPN
dpc-5918	414	2	.	.	PUNCT
dpc-5918	415	1	2021;12(6):e0343121	2021;12(6):e0343121	NUM
dpc-5918	415	2	.	.	PUNCT
dpc-5918	415	3	doi	doi	NOUN
dpc-5918	415	4	:	:	PUNCT
dpc-5918	415	5	10.1128	10.1128	NUM