Dermatology: Practical and Conceptual Research Letter | Dermatol Pract Concept. 2024;14(1):e2024035 1 Successful Treatment of Recalcitrant Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Diseases) With Apremilast Luca Bettolini1, Stefano Bighetti1, Paolo Incardona2, Piergiacomo Calzavara-Pinton1, Vincenzo Maione1 1 Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy 2 Departement of Pathology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy Key words: Sneddon-Wilkinson disease, subcorneal pustural dermatosis, neutrophilic dermatosis, apremilast Citation: Bettolini L, Bighetti S, Incardona P, Calzavara-Pinton P, Maione V. Successful Treatment of Recalcitrant Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Diseases) With Apremilast. Dermatol Pract Concept. 2024;14(1):e2024035. DOI: https://doi.org/10.5826/ dpc.1401a35 Accepted: July 30, 2023; Published: January 2024 Copyright: ©2024 Bettolini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing Interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding Author: Dr Luca Bettolini, Department of Dermatology, Spedali Civili, University of Brescia, Brescia, Italy. Tel +39 030 3995301 Fax +39 0303995015 E-mail: l.bettolini@unibs.it Introduction Subcorneal pustular dermatosis (SPD), also referred to as Sneddon-Wilkinson disease, is a chronic, rare condition of unknown origin characterized by the recurrent formation of sterile pustules in the superficial layers of the skin. These pustules typically appear in annular or serpiginous patterns and are commonly found on flexural surfaces and intertrigi- nous areas. In this case report, we present a patient with SPD successfully treated with apremilast. Case Presentation A 61-year-old man with a medical history of prostatic ade- nocarcinoma underwent radical prostatectomy two years prior, presented an 11-year history of SPD. During the phys- ical examination, the patient exhibited the presence of ves- icles, pustules, as well as superficial erosion, which resulted in the formation of fine scale and crusted lesions in the axil- lary regions (Figure 1A). The histopathological examination revealed the presence of subcorneal vesicles or pustules pri- marily composed of neutrophils, occasionally accompanied by eosinophils. Additionally, focal acantholysis was evident, along with vascular ectasia and congestion in the papillary dermis (Figure 2, A-C). Direct immunofluorescence and fungal stain were negative. No psoriasiform pattern of hyperplasia were observed as well. He had undergone several treatments, including dapsone 100 mg/daily, acitretin 25 mg/daily and colchicine 1 mg/daily with mild and transient improvement. Considering the contraindication of immunosuppressants due to unfavorable prognostic factors related to the pri- mary tumor, we decided to initiate oral apremilast treatment at a dosage of 30 mg twice a day. Remarkably, complete remission of the disease was achieved within two months (Figure 1B). No side effects or relapses occurred during six- month follow-up. 2 Research Letter | Dermatol Pract Concept. 2024;14(1):e2024035 Figure 1. Sneddon-Wilkinson disease. (A) Vesicles, pustules, fine scale and crusted lesions in the axillary regions. (B) Resolution of the lesions after 8 weeks therapy with apremilast. Figure 2. (A,B) Histopathology displaying a subcorneal pustule with thin roof leaning on the malpighian layer slightly sunken and an absent granular layer (H&E, 4x and H&E, 10x, respectively). (C) The superficial epidermis shows an acantholytic appearance below the pustule together with a granulocytic exocytosis (H&E, 40x). Research Letter | Dermatol Pract Concept. 2024;14(1):e2024035 3 In the management of SPD, oral dapsone is commonly considered as the initial treatment of choice. Several thera- peutic alternatives are available, including sulphapyridines, nicotinamide, oral corticosteroids, retinoids, and photo- therapy [1]. In some cases, off-label use of tumor necrosis factor-alfa blocking agents, interleukin-23 inhibitor (gusel- kumab) has also been reported as a potential treatment op- tion [2]. Furthermore, a case demonstrating improvement of recalcitrant SPD with the use of apremilast has been docu- mented [3]. Apremilast is an oral, small molecule inhibitor of phos- phodiesterase 4 (PDE4) that has gained approval for treat- ing psoriatic arthritis, Behcet disease and moderate-to-severe plaque psoriasis. It is also utilized off-label for the treatment of various dermatological conditions, including atopic der- matitis, hidradenitis suppurativa, alopecia areata and linear IgA bullous disease [4]. The exact pathogenesis of SPD is still unknown. The sub- corneal pustules are a result of neutrophil aggregation within the stratum corneum. Importantly, higher levels of multiple neutrophilic chemotactic factors including IL-8 and TNF-α have been observed within the uppermost epidermis and in the blister fluid, but also in the bloodstream [1]. Apremilast not only inhibits the production of IL-8, a crucial chemo- tactic factor for neutrophils but also reduces the levels of other proinflammatory cytokines such as TNF-α [5]. These cytokines play a significant role in neutrophil recruitment and infiltration, contributing to the disease pathogenesis. Furthermore, apremilast represents a drug with a highly favorable safety profile and can be used in patients with spe- cific comorbidities, such as a personal history of cancer. Conclusions In conclusion, this case report highlights the remarkable therapeutic efficacy of apremilast in the management of SPD, particularly in cases where conventional and off-label treat- ments have shown limited response or are contraindicated. References 1. Cheng S, Edmonds E, Ben-Gashir M, Yu RC. Subcorneal pustular dermatosis: 50 years on. Clin Exp Dermatol. 2008;33(3):229- 233. DOI:10.1111/j.1365-2230.2008.02706.x. PMID: 18355359. 2. Teraki Y, Sugai S. Treatment of recalcitrant subcorneal pustular dermatosis with guselkumab.  Int J Dermatol. 2021;60(4):e153-e154. DOI:10.1111/ijd.15311. PMID: 33226124. 3. Magdaleno-Tapial J, Valenzuela-Oñate C, Alonso-Carpio M, et al. 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