Dermatology: Practical and Conceptual Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 1 Infantile Hemangioma with Minimal or Arrested Growth (IHMAG): A Retrospective Analysis of Clinical and Dermoscopic Diagnostic Clues Iria Neri1, Gionathan Orioni2,3, Miriam Leuzzi1, Elena Facchini4, Elena Mengozzi5, Marco Adriano Chessa2,3 1 Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi, Bologna, Italy 2 Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi, Bologna, Italy 3 Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Italy 4 Pediatric Oncology and Hematology Unit “Lalla Seràgnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy 5 1st Radiology Department, Maggiore Hospital, Bologna, Italy Key words: IHMAG, infantile hemangioma, dermatoscopy, PHACE syndrome, LUMBAR syndrome, vascular malformations Citation: Neri I, Orioni G, Leuzzi M, Facchini E, Mengozzi E, Chessa MA. Infantile Hemangioma With Minimal or Arrested Growth (IHMAG): A Retrospective Analysis of Clinical and Dermoscopic Diagnostic Clues. Dermatol Pract Concept. 2024;14(3):e2024206. DOI: https://doi.org/10.5826/dpc.1403a206 Accepted: April 15, 2024; Published: July 2024 Copyright: ©2024 Neri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing Interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding Author: Gionathan Orioni, Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Via Massarenti 1, 40138 Bologna, Italy. Telephone: +390512144838 E-mail: gionathan.orioni@studio.unibo.it Introduction: Infantile hemangioma with minimal or arrested growth (IHMAG) is an unusual subset of infantile hemangioma, difficult to recognize because they are often mistaken for capillary malfor- mation or other entities. Dermoscopic features of IHMAG have been described only in small case series so far. Objectives: The aim of our study was to evaluate epidemiological, clinical, and dermoscopic features in 79 cases of IHMAG with a specific focus on neonates and toddlers with segmental complicated IHMAG and to provide a remarkable dermoscopic criterion to achieve diagnosis. Methods: This case series collected all the cases of IHMAG recorded in our Clinical Registry from January 2012 to March 2022. Results: A total of 79 cases of IHMAG were identified in our study; 53 (67.1%) were localized and 26 (32.9 %) were segmental. Patients showed some complications during follow-up such as ulceration and soft tissue anomalies. One PHACE syndrome and two LUMBAR syndromes were included. Our ABSTRACT 2 Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 Introduction Infantile hemangioma (IH) is the most common tumor of childhood that is usually absent at birth, appears in the first weeks of life, and undergoes a rapid growth phase followed by a period of slow involution with possible residual lesions [1,2]. In addition, IH express an erythrocyte-type glucose transport protein (GLUT-1) in their endothelial cells, which is a highly specific marker of IH [3]. The typical evolution makes them easy to diagnose clin- ically in most cases. IH with minimal or arrested growth (S) are an unusual subset of IH that are present at birth and characteristically have little or no proliferation (which has been defined as a pro- liferative component of <25% of their surface area) [4,5]. This variant of IH has been described with several different names: abortive, precursor, or minimal growth hemangiomas; macular hemangioma with port‐wine‐stain‐like appearance; reticular infantile hemangioma; and plaque‐­telangiectatic hemangio- mas [6,7]. Different from classic IH, the clinical diagnosis of IHMAG can be difficult because they can present as macular infantile hemangiomas with a network-like appearance, and they are often mistaken for vascular malformation [8,9]. The co-occurrence of IHMAG and structural anomalies is uncom- mon. However, some large segmental IHMAG extending to the face, buttocks, or limbs have been linked with structural anomalies in patients with PHACE, PELVIS, or SACRAL syn- dromes [5,10]. Other anomalies identified in these tumors are the presence of soft tissue hypotrophy or hypertrophy beneath the surface of the lesion [5,11]. Dermoscopy can be a useful tool for clinicians to better identify this type of hemangioma, allowing for differentiation from other clinically entities such as capillary malformations (CM) or IH. Complications and clinical and dermoscopic features of IHMAG have been previ- ously described only in small case series [6,7,12]. Objective The aim of our study was to evaluate epidemiological, clini- cal, and dermoscopic features in 79 cases of IHMAG with a specific focus on neonates and toddlers with segmental com- plicated IHMAG and to provide a remarkable dermoscopic criterion to achieve diagnosis. Methods This single-center retrospective study was conducted on 79 patients with IHMAG at the Pediatric Dermatology Unit of the University XXXXX from January 2012 to March 2022 using medical records and photographs. Clinical and dermoscopic images reported in this paper were all collected by our FotoFinder® video dermatoscopy archive database in our Dermatology Clinic Department. All the patients in- cluded were <3 years old. All the parents gave their written consent for scientific use of clinical and dermoscopic images. The term IHMAG is consistently used in this paper to avoid further misunderstandings about this kind of vascular proliferation. An IHMAG is defined as an infantile hemangi- oma with a proliferative component less than 25% of its total surface area [4,5]. Finally, dermoscopic features of IHMAG were retrospectively assessed by four dermatologists in order to assess remarkable dermoscopic criteria to achieve differ- ential diagnosis from IH and port-wine stain (PWS). A der- moscopic criterion was defined as remarkable in diagnosing IHMAG if at least three out of four dermatologists agreed. Results Clinical and Epidemiological Findings of IHMAG A total of 79 cases of IHMAG in as many subjects were iden- tified in our study. All the clinical characteristics of IHMAG, with their associations and complications, are illustrated in Table 1. All the lesions were noticed at birth as flat, reddish, and asymptomatic macules, with a female-to-male ratio of 2.4:1. The limbs were the most represented anatomical site with 37 (46.8%) IHMAG, 21 (26.6%) were located on the trunk, and 16 (20.3%) on the acral sites (hand or foot). Only five (6.3%) patients presented a lesion on the head and neck region. study highlights the main dermoscopic features differentiating IHMAG from infantile hemangiomas and capillary malformations in neonatal patients, highlighting the presence of enlarged unfocused telangiectatic vessels as remarkable clues. Conclusions: This is a large case series described in the literature about this rare entity. We emphasize that segmental IHMAG may be associated with structural abnormalities and may pose a diagnostic challenge especially in its rare facial segmental localization. The use of dermoscopy allowed us to find typical signs for IHMAG, thus avoiding the execution of invasive methods and ensuring the prompt suspicion of a syndrome in segmental neonatal cases. Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 3 IHMAGs were classified as focal or localized if they pre- sented as well-circumscribed small lesions, and segmental if they were larger and affected a specific area of the body such as the head, an acral site, genitalia, or the lumbosacral skin region. Fifty-three (67.1%) localized hemangiomas and 26 (32.9%) segmental lesions were identified, the latter af- fecting 14 (53.8%) females and 12 (46.2%) males. Limbs represented the most frequently involved site in segmental cases (13/26), while the others segmental lesions are local- ized on the hands or feet (8/26), the trunk (4/26), and on the head (1/26). Thirty-two cases presented a proliferative component, always < 25% of the total surface area. It clin- ically appeared as bright red papules, usually located at the periphery of the lesions. In most cases, proliferation started a few days after birth. In our study, all IHMAGs were characterized by a com- mon clinical presentation, with an erythematous network- like patch and blotchy appearance. These aspects were present either in focal or segmental types (Figure 1A). In seven patients, IHMAGs were associated with the presence of one or more IH, localized in other sites and occurring in the first weeks of life, with a classical growth phase in the first 12 months. Vascular malformations (VM) were observed at birth in five patients with IHMAG, and the differential diag- nosis was possible thanks to a different dermoscopic pattern of the two lesions. Dermoscopic Features of IHMAG and Differential Diagnosis On dermoscopic evaluation, red, dotted, or globular ves- sels, alone (51/79, 64.6%) or combined with dilated linear and tortuous vessels (28/79, 35.4%), were associated with enlarged unfocused telangiectatic vessels, present in all IHMAGs as a remarkable sign of the neoplasia. An erythem- atous background and structureless whitish areas were also observed, enlarging over time during the follow-up period, until it represented almost the entire lesion (Figure 2, A-D). Indeed, CMs were also characterized by red, dotted, or glob- ular vessels, alone or combined with dilated linear and tor- tuous vessels but without the presence of unfocused large telangiectatic vessels (Figure 2, E and F). IH were characterized by well-demarcated round or oval areas in which the color ranged from red to reddish-brown or reddish-blue, and the size varied within the lesion, called lacunae. Their presence is quite a constant dermoscopic finding in IH (Figure 2, G and H). Clinical and dermoscopic features and outcome of the described vascular lesions are reported in Table 2. Complications of IHMAG In our study, 13/79 patients showed some complications during follow-up in the first year of life. IHMAG with skin ulceration was detected in three patients of our analysis (Figure 2A); in two of these cases, the ulceration was associ- ated with the presence of other complications, such as spinal dysraphism and hypotrophy of the subcutaneous tissues. The peculiar aspect of ulcerated IHMAG lies in the difficulty of management: local dressings and systemic treatment with propranolol showed poor response in our cases as well as residual scarring. Two patients presented with segmental IHMAG associ- ated with underlying soft tissue hypertrophy, localized on the right limb and left hand, respectively. Soft tissue hypertrophy was clinically characterized by a soft doughy palpable mass underlying the skin lesion. The absence of underlying vas- cular and muscle anomalies on magnetic resonance imaging (MRI) supported the conclusion that this hypertrophy was primarily due to soft tissue overgrowth. Large telangiectasias Table 1. Clinical and Epidemiological Findings of IHMAG Among 79 Patients. Characteristics Value (%) Sex Male Female 23 (29.1) 56 (70.9) Morphologic subtype Focal Segmental 53 (67.1) 26 (32.9) Anatomic distribution Head and neck Trunk Limb Hand/foot 5 (6.3) 21 (26.6) 37 (46.8) 16 (20.3) Presence of proliferation Yes No 32 (40.5) 47 (59.5) Complications Ulceration Soft tissue hypertrophy Soft tissue hypotrophy Spinal dysraphism PHACE syndrome LUMBAR syndrome No complications 3 (3.8) 2 (2.5) 3 (3.8) 2 (2.5) 1 (1.3) 2 (2.5) 66 (83.6) Associated anomalies Infantile hemangioma Vascular malformation No other associated anomalies 7 (8.9) 5 (6.3) 67 (84.8) Systemic treatment Yes No 13 (16.5) 66 (83.5) IHMAG: = infantile hemangiomas with minimal or arrested growth. 4 Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 cardiological, and endocrinological evaluations were also performed. In addition, four patients in our series developed seg- mental IHMAG in the lumbosacral skin at birth (Figure 2B). After performing an imaging assessment of the pelvis and lumbosacral spinal cord, two patients presented with iso- lated spinal dysraphism, without any other anatomical mal- formations, while the others were diagnosed with LUMBAR (lower body congenital infantile hemangiomas and other skin defects; urogenital anomalies and ulceration; myelopa- thy; bony deformities; anorectal malformations and arterial anomalies; and rectal anomalies) syndrome. All the patients underwent surgical correction of spinal dysraphism and treatment of anatomical malformations. All 13 cases associated with complications underwent systemic treatment with propranolol hydrochloride in oral solution, as recommended by the current guidelines on IH [13]. It is important to underline that ten complicated and prominent veins were also observed, but the clinical appearance did not change over time. Three children presented localized soft tissue hypotrophy of the unilateral limb, where imaging investigations found only a reduction in the subcutaneous fatty tissue without other local abnormalities. One case reported a segmental vascular lesion in the left temporal region of the scalp, present at birth with minimal peripheral proliferation (Figure 2C). Specific dermoscopic criteria raised the suspicion of IHMAG, and an MRI of the head and neck was performed, which confirmed anomalies of the intracranial structures of the posterior fossa as well as the presence of ipsilateral neck carotid artery malfor- mations. This confirmed the clinical suspicion of PHACE (posterior fossa brain malformations, large facial hemangi- omas, anatomical anomalies of the cerebral arteries, aortic coarctation, and other cardiac anomalies, and eye abnormal- ities) syndrome, for which ophthalmological, neurological, Figure 1. Clinical characteristics of uncomplicated and complicated infantile hemangiomas with minimal or arrested growth (IHMAG). (A) Segmental uncomplicated IHMAG of the arm, with a minimal proliferative component. (B) Segmental patch of the left limb, perianal, and sacral region with a minimal proliferative component in this boy affected by LUMBAR syndrome. A subcutaneous swelling on the sacral area, consistent with spinal dysraphism, can be observed. (C) Large plaque of the left temporal side of the scalp, present at birth. Minimal growth can be seen at the peripheral region in this girl affected by PHACE syndrome. Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 5 Figure 2. Clinical and dermoscopic characteristics of infantile hemangiomas with minimal or arrested growth (IHMAG), capillary mal- formation, and infantile hemangioma. (A) Ulcerated segmental IHMAG of the right leg in a toddler, which showed (B) enlarged unfocused telangiectasia (black arrow) on an erythematous background composed of dotted globular vessels (yellow star) on dermoscopy. (C) Uncom- plicated segmental IHMAG of the right foot in a toddler with (D) multiple unfocused large telangiectasias (black arrow) on an erythematous background combined with dilated linear and tortuous vessels (yellow star) on dermoscopy. (E) Large segmental capillary malformation of the right leg in a toddler with (F) multiple red, dotted, or globular vessels on an erythematous background on dermoscopy. (G) Single infantile hemangiomas with a proliferative dermal component, with the (H) peculiar lacunae on dermoscopy. 6 Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 background composed of capillary dilations, not observed in CM [2]. In CMs, on the other hand, multiple red, dotted, or globular vessels, alone or combined with dilated linear and tortuous vessels, are the predominant signs on an er- ythematous whitish background, usually associated with a gray whitish veil (Figure 2, E and F) [16]. These aspects can easily distinguish between these two vascular lesions [17]. In doubtful cases, skin biopsy may be useful, as GLUT-1 results negative in vascular malformation, but in IHMAG, it is pos- itive for this marker at immunochemistry [1,18]. In addition, over time, IHMAG and CM have different clinical courses: IHMAG has a slight amount of prolifera- tion, which is characterized by peripheral small vascular papules in the context of the lesion. The proliferative com- ponent tends to stabilize in the first year of life, then it slowly regresses spontaneously [19]. CM, on the other hand, main- tains the clinical aspect of a flat lesion which grows propor- tionally to the child’s development, without showing signs of regression over time. Finally, CM and IHMAG can coexist in the same patient, as described in five cases of our retro- spective analysis. The early distinction between IHMAG and CM through dermoscopy allows for the initiation of a clin- ical follow-up during the first year of life. This is crucial to identifying potential complications associated with IHMAG, which do not arise in the case of CM. In our retrospective analysis, 11 patients presented IHMAG associated with several complications. However, as shown in the literature, segmental IH could also be as- sociated with ulceration, spinal dysraphism, LUMBAR syn- drome, and PHACE syndrome. Ulcerated IHMAG, usually localized in the anogenital area, has been reported in larger cases were associated with segmental IHMAG (38.5% of all segmental cases) but only three with focal ones. The other 66 patients underwent wait-and-see manage- ment through clinical follow-up, or therapy with topical beta blockers was prescribed to reduce the risk of proliferation and associated complications. Discussion During the drafting of this paper, the authors experienced difficulty in carrying out a complete literature search about IHMAG as already described. This may be explained by the small number of lesions described over the years, especially since IHMAG has only recently been classified as a specific subtype of classical IH. In addition, this subtype of IH has historically been defined using heterogeneous and poorly coded nomenclature, as clarified in the text above, leading to further difficulties in collecting cases from the literature. In this series, 70.9% of the patients were female, another known epidemiological characteristic of these lesions, which is in common with IH [13]. The anatomical distribution of these lesions is consistent with other reports in the literature [6]; in particular, IHMAG was mostly represented on the limbs (46.8% of the total) as focal or segmental lesions than on the face or trunk, in contrast with IH [14,15]. The large num- ber of segmental IHMAGs (32.9 % of the total) makes the differential diagnosis with other entities, such as CM and segmental IH, more difficult. Clinically, they both present as well-demarcated red macular stains, sometimes covered by fine telangiectasias [2]. At dermoscopy, IHMAG presents with enlarged unfocused telangiectasias on an erythematous Table 2. Clinical and Dermoscopic Features and Outcomes of IHMAG, IH, and Capillary Malformation. Onset IHMAG IH CM At Birth First Weeks of Life At Birth Clinical Focal or segmental flat reddish asymptomatic macules; a proliferative component, regarding <25% of the total surface area can be present Variable (red, finely lobulated plaque or bluish subcutaneous mass) Reddish and asymptomatic macules Dermoscopy Red, dotted, or globular vessels, alone or combined with dilated linear and tortuous vessels, were associated with enlarged unfocused telangiectatic vessels Well-demarcated round or oval areas called lacunae, in which the color can range from red to reddish-brown or reddish blue Multiple red, dotted, or globular vessels, reticular and sausage-like vessels as well as white circles and whitish veil Outcome Spontaneous regression Rapid growth phase, followed by a period of slow involution with possible residual lesions It grows proportionally to the child’s development, without showing signs of regression over time CM = capillary malformation; IH = infantile hemangioma; IHMA: = infantile hemangiomas with minimal or arrested growth. Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 7 longer as telangiectatic macules, unlike superficial IH, which regress completely, leaving only few dilated vessels [4]. Clin- ical and dermoscopic features and outcome of the described vascular lesions are reported in Table 2. The dermoscopic findings in our study population are comparable to the observations reported in the literature [29]. Fernández-Domper et al. [12] found the presence of vascu- lar lacunae in 100% of lesions diagnosed as IHMAG, while not observing the presence of telangiectatic vessels on an erythematous background. These differences are likely due to the fact that dermoscopic examination in their patients was performed at least one year after the onset of lesions, with changes in the pattern attributed to the physiological remodeling and spontaneous absorption of vascular prolif- erative components, while our data are referred to new onset IHMAG, in the first weeks after birth. The presence of lacu- nae may also be attributed to the minority proliferative com- ponent usually present in the peripheral areas of IHMAG but absent in the remaining flat part of the skin lesion. The main limitations are that this was a single-center study and the retrospective nature like other studies. Finally, dermoscopic differential diagnosis of IHMAG with capillary malformation and infantile hemangioma is only a descriptive analysis and not a case-control comparative study. Conclusions This paper presents a large retrospective study of IHMAG reported in a single-center experience with epidemiologi- cal, clinical, and dermoscopic features focused on neonates and toddlers. This large case series lets us better describe IHMAG, highlighting its clinical appearance and associated structural anomalies, above all with segmental lesions and dermoscopic features. Further investigations are needed to better understand the etiology of this condition as well as any negative prognostic factors. Dermoscopy allowed us to find the signs for IHMAG in order to achieve a prompt diag- nosis and to avoid a diagnostic pitfall with CM and local and segmental IH, thus avoiding the execution of invasive meth- ods or promptly suspecting a syndrome such as the PHACE syndrome on neonatal cases. References 1. Corella F, Garcia-Navarro X, Ribe A, Alomar A, Baselga E. Abor- tive or Minimal-Growth Hemangiomas: Immunohistochemical Evidence That They Represent True Infantile Hemangiomas. JAAD 2008, 58 (4), 685–690. https://doi.org/10.1016/j.jaad.2007 .08.007. 2. Toledo-Alberola F, Betlloch-Mas I, Cuesta-Montero L, et al. Abortive Hemangiomas. Description of Clinical and Pathological Findings with Special Emphasis on Dermoscopy. Eur J Dermatol 2010, 20 (4), 497–500. https://doi.org/10.1684/ejd.2010.0959. series [6]. However, there are no data regarding the prog- nosis and complications of these lesions. In the literature, there are some cases consisting of IHMAG associated with and soft tissue hypertrophy and hypotrophy [1,6]. Planas- Ciudad et al. [5] described ten patients with similar charac- teristics, localized on the arms or legs. Prognosis is similar to the other IHMAG without subcutaneous involvement, but these rare cases have to be differentiated from other condi- tions, such as venous, arteriovenous, or CM, which can show different complications over time. Bessis et al. [11] reported seven IHMAG cases with hypotrophy, where the clinical characteristics are superimposable. According to the litera- ture, MRI imaging should be performed on all the patients with IHMAG-associated abnormality of soft tissue [20]. PHACE and LUMBAR syndromes are usually reported with the presence of a segmental IH, while cases of asso- ciation with segmental IHMAG are rare or misdiagnosed [25,28]. This emphasizes the importance of early recognition of this association in order to carry out a complete diagnos- tic investigation and start systemic treatment, avoiding the onset of complications [21]. Until about ten years ago, it was a common opinion to discriminate between three different forms of syndromes associated with segmental IH of the pelvic and lumbosa- cral area: PELVIS, LUMBAR, and SACRAL. Currently, to avoid confusion, the denomination LUMBAR is preferred to indicate forms of segmental IH of the lower body, associ- ated with regional congenital anomalies [22,23]. Cases of LUMBAR associated with IHMAG are very rare in the liter- ature [24,25]. Suh and Frieden [6] reported a single case of lumbar IHMAG associated with regional anomalies in their study, emphasizing the role of this apparently benign lesion as a marker of serious regional abnormalities. Seven patients in our study presented with the coexis- tence of IHMAG and IH, occurring mostly in the weeks after birth as fast-growing erythematous plaques often associated with a proportion of subcutaneous proliferation [26,27]. In sporadic cases, IH may present a precursor lesion similar to IHMAG, as it is characterized by an erythematous and telan- giectatic patch without a proliferating component. However, these lesions differ in the presence of an anemic halo in the peripheral area, which is not seen in IHMAG [28]. The de- velopment of these two lesions in the subsequent weeks will lead to a definitive diagnosis. IH at dermoscopy are characterized by well-demarcated round or oval areas in which the color can range from red to reddish brown or reddish blue, and the size can vary within the lesion, called lacunae (Figure 2, G and H). The deep, mixed IH, unlike the exclusively superficial ones, present a more bluish background on dermatoscopy [17]. The natural history of these lesions presents some differences: IHMAG, having a low or absent proliferating amount, tend to persist 8 Original Article | Dermatol Pract Concept. 2024;14(3):e2024206 16. Lanigan SW. Videomicroscopy Predicts Outcome in Treatment of Port-Wine Stains. Arch Dermatol 1997, 133 (7), 921. https://doi .org/10.1001/archderm.1997.03890430143029. 17. Piccolo V, Russo T, Moscarella, Brancaccio G, Alfano R, Argenziano G. Dermatoscopy of Vascular Lesions. Dermatolog Clin 2018, 36 (4), 389–395. https://doi.org/10.1016/j.det.2018.05.006. 18. Harik , Kalaria R, Andersson L, Lundahl P, Perry G. Immunocy- tochemical Localization of the Erythroid Glucose Transporter: Abundance in Tissues with Barrier Functions. J. Neurosci. 1990, 10 (12), 3862–3872. https://doi.org/10.1523/JNEUROSCI.10-12 -03862.1990. 19. Bae K-N, Shin K, Kim H-S, Kim B-S, Kim M-B, Ko H-C. In- fantile Hemangiomas with Minimal and Arrested Growth: Clinical Features and Treatment Outcomes with 0.5% Topical Timolol Maleate. Ann Dermatol 2021, 33 (5), 448. https://doi.org /10.5021/ad.2021.33.5.448. 20. Stillo F, Mattassi R, Diociaiuti, et al. Guidelines for Vascu- lar Anomalies by the Italian Society for the Study of Vascular Anomalies (SISAV). Int Angiol 2022, 41 (2 Suppl 1). https://doi .org/10.23736/S0392-9590.22.04902-1. 21. Leuzzi M, Sechi A, Filippi F, Di Altobrando A, Gurioli C, Neri I. Infantile Hemangioma with Minimal or Arrested Growth and Isolated Spinal Dysraphism: A New or Underrecognized Entity? Indian J Dermatol 2021, 66 (5), 559. https://doi.org/10.4103 /ijd.IJD_267_20. 22. Iacobas I, Burrows PE, Frieden IJ, et al. LUMBAR: Association between Cutaneous Infantile Hemangiomas of the Lower Body and Regional Congenital Anomalies. J Pediatr 2010, 157 (5), 795-801.e7. https://doi.org/10.1016/j.jpeds.2010.05.027. 23. Frade F, Kadlub N, Soupre V, Cassier S, Vazquez M-P, Picard A. Du PELVIS au LUMBAR syndrome : à propos de 2 cas. Archives de Pédiatrie 2012, 19 (1), 55–58. https://doi.org/10.1016 /j.arcped.2011.10.004. 24. Martínez-Criado Y, Fernández-Pineda I, Merchante E, Bernabeu-Wittel J. Lumbosacral Abortive Hemangioma with Intradural Extension. Pediatr Dermatol 2014, 31 (3), e80–e81. https://doi.org/10.1111/pde.12234. 25. Calderón-Castrat X, Peceros-Escalante J, Velásquez F, Lipa- Chancolla RM, Ballona R. Hemangioma infantil de crecimiento mínimo o detenido segmentario en un síndrome LUMBAR. Actas Dermo-Sifiliográficas 2017, 108 (5), 475–477. https://doi.org/10.1016/j.ad.2016.10.003. 26. Chang LC, Haggstrom AN, Drolet BA for the Hemangioma Investigator Group, et al. Growth Characteristics of Infantile Hemangiomas: Implications for Management. Pediatrics 2008, 122 (2), 360–367. https://doi.org/10.1542/peds.2007-2767. 27. Bruckner AL, Frieden IJ. Hemangiomas of Infancy. JAAD 2003, 48 (4), 477–496. https://doi.org/10.1067/mjd.2003.200. 28. Payne MM, Moyer F, Marcks KM, Trevaskis AE. The Precursor to the Hemangioma: PlastReconstr Surg 1966, 38 (1), 64–67. https://doi.org/10.1097/00006534-196607000-00013. 29. Oiso N, Kimura M, Kawara S, Kawada A. Clinical, Dermoscopic, and Histopathologic Features in a Case of Infantile Hemangioma without Proliferation. Pediatr Dermatol 2011, 28 (1), 66–68. https://doi.org/10.1111/j.1525-1470.2010.01363.x. 3. North, PE, Waner, M.; Mizeracki, A.; Mihm, M. C. GLUT1: A Newly Discovered Immunohistochemical Marker for Juvenile Hemangiomas. Human Pathology 2000, 31 (1), 11–22. https:// doi.org/10.1016/S0046-8177(00)80192-6. 4. Ma EH, Robertson SJ, Chow CW, Bekhor PS. Infantile Hemangi- oma with Minimal or Arrested Growth: Further Observations on Clinical and Histopathologic Findings of This Unique but Under- recognized Entity. Pediatr Dermatol 2017, 34 (1), 64–71. https:// doi.org/10.1111/pde.13022. 5. Planas-Ciudad S, Roé Crespo E, Sánchez-Carpintero I, et al. Infantile Hemangiomas with Minimal or Arrested Growth As- sociated with Soft Tissue Hypertrophy: A Case Series of 10 Pa- tients. J Eur Acad Dermatol Venereol 2017, 31 (11), 1924–1929. https://doi.org/10.1111/jdv.14457. 6. Suh K-Y, Frieden IJ. Infantile Hemangiomas With Minimal or Arrested Growth: A Retrospective Case Series. Arch Dermatol 2010, 146 (9). https://doi.org/10.1001/archdermatol.2010.197. 7. Martin JM, Sanchez S, González V, Cordero P, Ramon D. Infan- tile Hemangiomas with Minimal or Arrested Growth: A Retro- spective Case Series. Pediatr Dermatol 2019, 36 (1), 125–131. https://doi.org/10.1111/pde.13695. 8. Vega Mata N, López Gutiérrez JC, Vivanco Allende B, Fernández García MS. Different Clinical Features of Acral Abor- tive Hemangiomas. Case Rep Dermatolog Med2017, 2017, 1–5. https://doi.org/10.1155/2017/2897617. 9. Martín-Santiago A, Bauzá A, del Pozo LJ, Carrillo P. Hemangiomas abortivos o mínimamente proliferativos. Revisión de 14 casos. Actas Dermo-Sifiliográficas 2012, 103 (3), 246–250. https://doi.org/10.1016/j.ad.2011.03.030. 10. Metry DW, Haggstrom AN, Drolet BA, et al. A Prospective Study of PHACE Syndrome in Infantile Hemangiomas: Demo- graphic Features, Clinical Findings, and Complications. Am. J. Med. Genet. 2006, 140A (9), 975–986. https://doi.org/10.1002 /ajmg.a.31189. 11. Bessis D, Bigorre M, Labrèze C. Reticular Infantile Hemangi- omas with Minimal or Arrested Growth Associated with Li- poatrophy. JAAD 2015, 72 (5), 828–833. https://doi.org/10.1016 /j.jaad.2015.01.028. 12. Fernandez-Domper L, Silva Diaz E, Ballesteros Redondo M, Martín Hernández JM, Revert Fernandez A. Dermoscopy of Abortive Hemangioma: Morphological Study of 11 Cases. Der- matol Pract Concept 2023, e2023098. https://doi.org/10.5826 /dpc.1302a98. 13. Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong L-CF. Infantile Hemangioma. Part 1: Epidemiology, Pathogenesis, Clinical Presentation and Assessment. JAAD 2021, 85 (6), 1379–1392. https://doi.org/10.1016/j.jaad.2021.08.019. 14. Haggstrom AN, Drolet BA, Baselga E, et al. Prospective Study of Infantile Hemangiomas: Clinical Characteristics Predicting Com- plications and Treatment. Pediatrics 2006, 118 (3), 882–887. https://doi.org/10.1542/peds.2006-0413. 15. Chiller KG, Passaro D, Frieden IJ. Hemangiomas of Infancy: Clinical Characteristics, Morphologic Subtypes, and Their Rela- tionship to Race, Ethnicity, and Sex. Arch Dermatol 2002, 138 (12). https://doi.org/10.1001/archderm.138.12.1567.