Dermatology: Practical and Conceptual Image Letter | Dermatol Pract Concept. 2025;15(1):4898 1 Psoriatic Isomorphic Response From Molluscum Contagiosum Iswariya Jaganathan1, Dineshkumar Selvaraj1, Navya Donaparthi1, Debdeep Mitra1 1 Department of Dermatology, Command Hospital Air Force Bangalore, India Citation: Iswariya J, Dinesh Kumar S, Navya D, Mitra D. Psoriatic Isomorphic Response From Molluscum Contagiosum. Dermatol Pract Concept. 2025;15(1):4898. DOI: https://doi.org/10.5826/dpc.1501a4898 Accepted: November 9, 2024; Published: January 2025 Copyright: © Iswariya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing Interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding Author: Dr. Iswariya J, MBBS, Department of Dermatology, Command Hospital Air Force Bangalore, India. E-mail: iswariyajaganathan@live.in Case Presentation An 11-year-old girl with known history of psoriasis vulgaris presented complaining of a few asymptomatic skin-col- ored raised lesions over both arms and shoulders appeared 2 months before. More recently she noticed the development of itchy, flaky, erythematous patches over these areas. Clinical examination revealed few discrete skin-coloured umbilicated papules 0.3 x 0.3 cm in size over the left shoulder and the infraclavicular regions sourranded by discrete erythematous plaques with silvery-white scales. Dermoscopic examination of the psoriatic plaque revealed pinkish-white homogenous areas with white scales and regular dotted vessels (Figure 1). Teaching Point A clinical diagnosis of psoriatic isomorphic response surround- ing the preexisting molluscum contagiosum was made (1). The patient was managed with needle extirpation of the molluscum contagiosum along with topical steroids for the psoriatic plaques, which resulted in the resolution of symptoms. 2 Image Letter | Dermatol Pract Concept. 2025;15(1):4898 References 1. Ji YZ, Liu SR. Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms.  Biosci Rep. 2019;39(12):BSR20193266. DOI:10.1042/BSR20193266. PMID: 31710084. PMCID: PMC6893164. Figure 1. (A) Multiple discrete erythematous scaly plaques around the central umbilicated papules of molluscum contagiosum. (B) Close-up view of molluscum contagiosum (black star) with surrounding psoriatic plaque (black arrow). (C) Dermoscopy of the molluscum contagiosum showing a whitish yellow papule with homogenous amorphous structure in the center (white arrow). (D) Psoriatic plaque: pinkish white homogenous areas with white scales and regular dotted vessels (blue star).