Dermatology: Practical and Conceptual Research Letter | Dermatol Pract Concept. 2025;15(4):5315 1 Dermatoscopic Patterns in Keloid, Hypertrophic, and Atrophic Scars: Cross-Sectional Analysis and Clinical Correlation Leonne Del Vecchio1,2, Jan Lapinso3, Leandra d’Orsi Metsavah4, Geise Cristine Espíndola5, Elizabeth Leocadia Fernandes4, Keila Seabra Teles Ferreira6, Marcio Roberto Silva9, Jussara Aparecida da Silva9, Gisele Viana de Oliveira5,7,8 1 University of Taubaté, Bom Conselho, Taubaté, Brazil 2 Hospital Municipal Universitário de Taubaté, Brazil 3 Department of Dermatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Swedenl 4 Metsavaht Dermatology and Santa Casa Hospital, Rio de Janeiro, Brazil 5 Luxemburgo/Mário Penna Hospital, Dermatology Department, Belo Horizonte, Brazil 6 Medical Sciences University of Minas Gerais, Postgraduate Department, Belo Horizonte, Brazil 7 GV Dermatology, Belo Horizonte, Brazil 8 University of Minas Gerais, Postgraduate Department, Belo Horizonte, Brazil 9 University of Juiz de Fora, Postgraduate Department in Collective Health, Juiz de Fora, Brazil Key words: Dermatoscopy; Keloid, Hypertrophic scar, Vascular patterns; Scar maturation Citation: Metsavah LdO, Espíndola GC, Fernandes EL, et al. Dermatoscopic Patterns in Keloid, Hypertrophic, and Atrophic Scars: Cross-Sectional Analysis and Clinical Correlation. Dermatol Pract Concept. 2025;15(4):5315. DOI: https://doi.org/10.5826/ dpc.1504a5315 Accepted: February 20, 2025; Published: October 2025 Copyright: ©2025 Metsavah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. Funding: None. Competing Interests: None. Authorship: All authors have contributed significantly to this publication. Corresponding Author: Leonne Del Vecchio, Medical Resident at the Dermatology Department, University of Taubaté, and Hospital Municipal Universitário de Taubaté, Brazil. E-mail: leonnedicarlo.derma@gmail.com Introduction Keloids, hypertrophic scars, and atrophic scars represent distinct forms of abnormal wound healing. Differentiating between these entities is often based on clinical and histo- pathological criteria. Dermatoscopy has been suggested as a supportive tool in this differentiation, yet published data remain limited. While earlier studies proposed that dermatoscopy could assist in distinguishing scar subtypes, we aimed to clarify its role by analyzing a broad set of der- matoscopic images. Our findings demonstrate that derma- toscopy is more effective for evaluating scar activity and maturation than for classifying scar types. 2 Research Letter | Dermatol Pract Concept. 2025;15(4):5315 Case Presentation A dermatoscopic evaluation was conducted on 68 scars (38 keloids, 20 hypertrophic scars, and 10 atrophic scars) at a dermatology outpatient clinic using polarized digital der- matoscopy (Fotofinder©). Clinical and dermatoscopic find- ings focused on vascular patterns, color, and the presence or absence of skin appendages. In keloids (N=38), arborizing (branched) vessels were observed in 36.8% of cases, often associated with white or yellow structureless areas, indicating dense collagen nodules. Dotted vessels were less frequent. Mature keloids showed reduced vascularity, and in some cases, reappearance of trapped hair follicles, suggesting a transition to a regres- sive phase. In hypertrophic scars (N=20), thin linear vessels were the most common vascular pattern (50%), along with pinkish or reddish areas and parallel white bands, likely corresponding to compact collagen bundles. Atrophic scars (N=10), often following intralesional corticosteroid therapy, exhibited prominent arborizing vessels (70%) and dermal thinning. These scars lacked curved or dotted vessels, helping differentiate them from proliferative-phase scars. Statistical analysis revealed that vascular patterns (ar- borizing, linear, dotted) were more strongly correlated with scar activity (e.g., inflammation, growth phase) than with scar subtype (Figure 1). Dermatoscopy also revealed the reappearance of pilosebaceous units during scar re- gression, serving as a useful marker of scar maturation (Figure 2). Dermatoscopic findings are summarized in Table 1. Conclusions Dermatoscopy is not reliable for distinguishing between ke- loids and hypertrophic scars based solely on morphology. However, its true clinical utility lies in tracking scar dynam- ics, such as vascular patterns, color changes, and follicular visibility, which reflect scar activity and maturation phase rather than classification. Keloids in active growth show arborizing vessels and yel- low-white structureless areas, while reduced vascularity and reappearance of follicles indicate regression. Hypertrophic Figure 1. Dermatoscopic patterns of curved, crossing and arborizing (A), linear (B) and dotted (C) vessels. Branched vessels increased significantly across scar types (P=0.005), especially in atrophic lesions. Linear and curved vessels showed progressive trends by scar type. Research Letter | Dermatol Pract Concept. 2025;15(4):5315 3 Figure 2. (A) Macroscopic image showing a treated scar on the left thigh. (B) Under dermoscopy, hair follicles are identified extruding from non-hypertrophic scar tissue. As scar thickness decreases, der- matoscopy reveals the return of previously trapped hair follicles. Preserving these structures during treatment may support repigmen- tation and enhance the scar’s cosmetic appearance. Table 1. Dermatoscopic features of patients with atrophic, hypertrophic, and keloid Scars. General Dermoscopic Findings Finding Keloid Scars (N=38) Hypertrophic Scars (N=20) Atrophic Scars (N=9) Erythematous areas 9 (23.7%) 3 (15.0%) 2 (22.2%) Blood Vessels Vascular Pattern Keloid Scars (N=38) Hypertrophic Scars (N=20) Atrophic Scars (N=9) Arborizing (branched) vessels 14 (36.8%) 2 (10.0%) 6 (66.7%) Linear vessels 11 (28.9%) 10 (50.0%) 1 (11.1%) Dotted / comma-like (curved) vessels 6 (15.8%) 0 (0.0%) 1 (11.1%) Abbreviations: N: number of lesions; values in parentheses represent percentages. Statistical analysis: Fisher’s exact test showed a significant association between arboriform (branched) vessels and scar type (P=0.005). No statistically significant association was found for erythema- tous areas (P=0.69), linear vessels (P=0.10), or dotted/comma-like (curved) vessels (P=0.13). reminiscent of a distorted reticular vascular pattern, may be indicative of the emergence of the reticular vascular pattern of superficial plexus of normal skin in the maturation of a scar. Dermatoscopy thus serves as a noninvasive, practical tool for monitoring scar progression and guiding treatment decisions, particularly timing and selection of adjunctive therapies like laser, cryotherapy, or energy-based devices. Dermatoscopy enhances the clinical assessment of ab- normal scars by identifying features linked to scar activity and evolution. Though it cannot differentiate scar types de- finitively, it provides valuable insights into scar maturation and treatment response, supporting personalized and opti- mized care. References 1. Yoo MG, Kim IH. Keloids and hypertrophic scars: char- acteristic vascular structures visualized by using dermos- copy. Ann Dermatol. 2014;26(5):603–9. DOI:10.5021/ ad.2014.26.5.603. 2. Abdallah M, Yassin M, Saber N. Dermoscopic features of keloid versus hypertrophic scar. Egypt J Hosp Med. 2018;70(4):621–4. DOI:10.12816/0043814. 3. Deng H, Li-Tsang CWP, Li J. Measuring vascularity of hypertro- phic scars by dermoscopy: construct validity and predictive ability of scar thickness change. Skin Res Technol. 2020;26(3):369–75. DOI:10.1111/srt.12812. 4. de Oliveira, G. V., Sanford, A. P., Murphy, K. D., de Oliveira, H. M., Wilkins, J. P., Wu, X., Hawkins, H. K., Kitten, G., Chinkes, D. L., Barrow, R. E., & Herndon, D. N. (2004). Growth hormone ef- fects on hypertrophic scar formation: A randomized controlled scars show linear vessels that diminish with maturation along with increased follicular visibility. In atrophic scars, prominent arborizing vessels are typically shown due to steroid-induced dermal thinning, although arborizing vessels,