DR [page 36] [Dermatology Reports 2017; 9:7198] Eyelid dermatitis caused by allergic contact to acrylates in artificial nails Jorge Moreira, Rita Gonçalves, Pedro Coelho, Tiago Maio Department of Ophthalmology, Hospital Pedro Hispano, Porto, Portugal Abstract Over the past few years, there has been an increase in cases of allergic contact der- matitis caused by acrylates, because of the growing popularity of artificial nails. Pathological reactions to artificial nails typ- ically occur on or around the nail area. Eyelid contact dermatitis due to artificial nails is rarely seen, especially in a non- occupational setting. The authors report the case of a 45-year-old female accountant who developed eyelid dermatitis due to arti- ficial nails. Introduction The eyelid is one of the most sensitive areas of the body as the skin of the eyelid is extremely thin and is exposed to an extraor- dinary number of substances. For this rea- son, eyelid dermatitis is a common disease, and a variety of factors, including primary skin diseases and external insults may cause eyelid erythema. Determining the underly- ing etiology may prove especially challeng- ing, because eyelid rashes, regardless of the cause, look very similar. Allergic contact dermatitis (ACD) is considered the most common cause of eye- lid dermatitis, and its prevalence ranges from 46% to 74%.1,2 Acute ACD often presents with intense pruritus and a well-demarcated erythema of the eyelids whereas subacute and chronic forms are less erythematous, and are char- acterized by dry, scaly and lichenified skin.3 The list of allergens that are potentially associated is extensive, and it includes top- ical pharmaceutical products, cosmetics, metals, rubber derivatives, and plants.4 The causal contact allergens may be of occupa- tional or non-occupational origin and may come into contact with the eyelid skin in several ways. Most often, eyelid contact dermatitis is the result not from direct peri- ocular exposure, but rather due to ectopic reactions, caused by substances applied to the hair, face, scalp or fingernails.5 The eye- lid is also particularly susceptible to ACD from airborne allergens.5 Due to its excep- tional vulnerability, eyelid skin may be the initial or only area that demonstrates signs of contact dermatitis, while other areas of the body remain unaffected by the same exposure.5 Here, we present the case of a woman who developed eyelid dermatitis due to acrylates in artificial nails. Case Report A 45-year-old female accountant pre- sented with a one-week history of a pruritic and symmetric redness of the eyelids. Examination showed edema and a well- defined erythema of both eyelids (Figure 1). At the slit lamp exam, eye examination was normal. There was no personal or family history of atopy. A detailed history of her exposures revealed that she wore photobonded acrylic gel nails. She had no skin lesions elsewhere, namely on the hands, periungual area or nails. Patch tests with the Portuguese Standard and Acrylates series (Chemotechnique® Diagnostics, Vellinge, Sweden) applied using Finn® Chambers on Scanpor® tape (Epitest Ltd Oy, Tuusula, Finland) were performed and readings at D2 and D4 revealed positive reactions to ethylacrylate 1% (++), methyl metacrylate monomer 10% (+), and 2-hydroxyethyl- methacrylate (++). The results were consistent with the diagnosis of allergic contact dermatitis to artificial nails containing acrylates. The eyelid dermatitis resolved follow- ing application of topical corticosteroid and removal of the artificial nails. Discussion Acrylates are plastic materials that are formed by the polymerization of monomers derived from acrylic or methacrylic acid. They can be found in a wide variety of products, including adhesives, glues, paints, and artificial nails. Acrylates are well-known for their sen- sitizing potential, and for causing ACD in those exposed to the monomers. Classically, ACD caused by acrylates was considered primarily an occupational disease, affecting mainly dentists, prosthesis technicians, painters, and workers in the fiberglass and graphic printing industries.6 In the last few years, with the widespread use of artificial nails, an increasing number of cases of allergic contact dermatitis caused by acry- lates have been reported particularly in nail technicians, but also among artificial nail users.7-9 Exposure to acrylates in artificial nails may induce a wide variety of clinical mani- festations. Reactions in nail users, most commonly, occur on or around the nail area, and include paronychia, onychodystrophy, onycholysis, nail bed hyperkeratosis, painful nails, and occasionally, paresthe- sia.10,11 In the case of the nail technicians, the most frequent adverse reaction is hand dermatitis, through manipulation of unpoly- merized acrylates.7 Unlike what happens with traditional nail varnishes, ACD caused by the acrylates present in the artificial nails usually pro- duces lesions at the site of application to the nail itself, and only very rarely affects dis- tant areas, such as the face and eyelids.7,8,12 Distant ACD can be explained by hand transportation or airborne dissemination of the allergen.13 The acrylate monomer is a powerful sensitizer, whereas the polymer is signifi- cantly weaker or non-sensitizing, and because of this feature, distant allergic reac- tions to acrylate-containing artificial nails Dermatology Reports 2017; volume 9:7198 Correspondence: Jorge Moreira, Department of Ophthalmology, Hospital Pedro Hispano, Rua Dr. Eduardo Torres, 4464-513, Senhora da Hora, Porto, Portugal. Tel.: +351.229391000. E-mail: jorgemoreira.fm@gmail.com Key words: Eyelid; contact dermatitis; artifi- cial nails; acrylates. Acknowledgments: we thank the Department of Dermatology for all the help in this clinical case. Contributions: JM, Conception of the work; data collection, and interpretation; drafting and revising the manuscript; literature review; final approval of the manuscript to be pub- lished. RG, PC, TM, analysis and interpreta- tion of data; manuscript review; literature review; final approval of the manuscript to be published. Conflict of interest: the authors declare no potential conflict of interest. Received for publication: 23 April 2017. Accepted for publication: 22 May 2017. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). ©Copyright J. Moreira et al., 2017 Licensee PAGEPress, Italy Dermatology Reports 2017; 9:7198 doi:10.4081/dr.2017.7198 No n c om me rci al us e o nly [Dermatology Reports 2017; 9:7198] [page 37] are uncommon.5,6 In our case, contact with monomer might have occurred before poly- merization, or small amounts of monomer might have remained unpolymerized, or the filling process of completely polymerized resins might have released the monomer.11,14 Conclusions Contact dermatitis is the most common cause of eyelid dermatitis, therefore, a detailed exposure history is essential for an accurate diagnosis and successfull manage- ment. This report highlights a hypersensi- tivity reaction to artificial nails involving an unusual location, particularly in a non-occu- pational setting, and stresses the importance of considering nail cosmetics in the evalua- tion of eyelid dermatitis. References 1. Nethercott JR, Nield G, Holness DL. A review of 79 cases of eyelid dermatitis. 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