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Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

Exploration

On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

Matti Pitkänen 1

Abstract

In TGD, magnetic body is an intentional agent using biological body as a sensory receptor and
motor instrument. TGD also provides various mechanism used by magnetic body for control and
communication purposes, and the notion of bio-harmony suggests itself as a correlate for quantum
coherence at the level of basic bio-molecules. How magnetic body and bio-harmony could help to un-
derstand biology? Can one identify biological phenomena making these notions compelling? In this
article some candidates for phenomena of this kind are briefly discussed. The finding that behavioral
patterns of planaria can be remembered also by the piece of split planaria without brains is consistent
with the idea that replication of magnetic body coding for behaviors is behind biochemical replica-
tion. That alleles of the same gene have different expression could be understood if the bio-harmony
assignable to gene carries additional information besides the biochemical information. These notions
might help to understand the mechanisms epigenetic. Histone modification and DNA methylation are
believed to involve geometric locking preventing transcription. They could also affect the frequency
assignable to DNA codon or some key unit so that the resonance condition making possible reconnec-
tion of U-shaped flux tubes allowing biomolecules to get in contact and for transcription to proceed
fails to be satisfied. Epigenetic inheritance could reduce to inheritance of bio-harmony: the magnetic
bodies of cells of offspring get in tune with those of parent.

1 Introduction

What TGD can possibly give to biology is the vision about magnetic body [8] as an intentional agent
using biological body as a sensory receptor and motor instrument and about various mechanism used by
magnetic body for control and communication purposes. A new element is brought in by Zero Energy
Ontology: magnetic body is 4-dimensional and thus correlate for a behavioral pattern rather than 3-
D state for part of organism. Also the notion of bio-harmony [9] [7] suggests itself as a correlate for
quantum coherence at the level of basic bio-molecules. How magnetic body and bio-harmony could help
to understand biology? Can one identify biological phenomena making these notions compelling?

In this article some candidates for phenomena of this kind are briefly discussed. The finding that
behavioral patterns of planaria can be remembered also by the piece of split planaria without brains
is consistent with the idea that replication of magnetic body coding for behaviors is behind biochemical
replication. That alleles of the same gene have different expression could be understood if the bio-harmony
assignable to gene carries additional information besides the biochemical information.

These notions might also provide a fresh approach to epigenetics. Histone modification and DNA
methylation are believed to induce kind of geometric locking preventing transcription. They could also
affect the frequency assignable to DNA codon or some key unit so that the resonance condition making
possible reconnection of U-shaped flux tubes allowing biomolecules to get in contact fails and transcription
cannot proceed. Epigenetic inheritance could reduce to the inheritance of bio-harmony: the magnetic
bodies of cells of offspring get in tune with those of parent. To how high degree magnetic body and
bio-harmony are inherited? This becomes the key question.

1Correspondence: Matti Pitkänen http://tgdtheory.com/. Address: Köydenpunojankatu 2 D 11 10940, Hanko, Finland.
Email: matpitka@luukku.com.

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

http://tgdtheory.com/
mailto:matpitka@luukku.com


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 73

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

1.1 The notions of 4-D magnetic body and bio-harmony

Recall first some key ideas of TGD inspired quantum biology.

1. In TGD framework magnetic body extends the pair formed by organism and environment to a
kind of holy trinity. Magnetic flux tubes and the realization of genetic code in terms of dark
proton sequences has been the key hypothesis. The model for cold fusion (see http://tgdtheory.

fi/public_html/articles/cfagain.pdf) [?] suggests that also more general dark nuclei must be
allowed. Dark neutron sequences could correspond to genes separated by dark protons. Dark weak
interactions with large value of heff effectively massless below neuron size scale would play central
role and induce large parity breaking effects (chiral selection).

The chemistry would not be all that matters. DNA-nuclear/cell membrane as topological quantum
computer with braided magnetic flux tubes would explain why organisms with virtually identical
genomes are so different (we and our ancestors for instance). The hierarchy of magnetic bodies
would be responsible for the development of intelligence and for cultural evolution. Flux tubes
connecting DNA and mRNA as well as mRNA and tRNA molecules are present but it is difficult
to say anything concrete.

2. Ontogeny could be seen as a kind of editing process for the text defined by the DNA. Control of
control of... is involved so that situation is very complex. Who performs the editing? Does DNA
edit itself and is the editing process defining evolution of genome coded by genome? Or is the editing
performed by Darwinian selection at cell level (see https://en.wikipedia.org/wiki/Cellular_

differentiation)? Or is the magnetic body the editor using genome also as its tool as TGD
would suggest? What is important that in TGD framework self-organization in 4-D sense implied
by Zero Energy Ontology replaces ordinary self organization leading to asymptotic spatial patterns
and select spatiotemporal patterns as asymptotic behavioral patterns defining various biological
functions. The role of magnetic body is central in this process.

3. Magnetic body contains cyclotron Bose-Einstein condensates and cyclotron frequencies determined
by the strength of magnetic field would give for DNA and other biomolecules additional character-
istics. In TGD based model for musical harmony DNA codons would correspond quite concretely
to 3-chords but played using dark photons (also ordinary music represented as sounds could be
transformed to dark photon music). If one accepts the icosahedral model of bio-harmonies predict-
ing genetic code correctly, there would be 256 fundamental harmonies characterised by the allowed
collection of 3-chords and they would add to the information carried by DNA molecules. I have
constructed a program building random sequences of the allowed chords using the additional har-
monic rule that two subsequent chords contain at least one common note and this music sounds
rather harmonic (albeit boring in absence of any other elements!)

4. Could one distinguish between different states/phases of DNAs, mRNAs, tRNAs, and amino acids
in terms of harmony? Could their functioning depend on the harmony? With the inspiration
coming from the connection of emotions and musical harmonies I have proposed that the harmony
associated with a gene or organ could correlate with something analogous to an emotional state
or mood - maybe micro-mood or microemotion could be the proper notion. Could amino-acids be
happy, hilarious, melancholic, sad, depressed? Could one distinguish between different phases of
DNA, RNA, tRNA, aminoacid collections characterized by the harmony in turn characterizing the
of a cell, organelle, organ, or even organism? tRNA defines the map of the harmony associated with
DNA codons to amino-acid harmony. Is the information about DNA codon and about corresponding
3-chord represented at the level of magnetic body of amino-acid- that is as the 3-chord, which it
represents, and realized as the rules telling with which tRNAs amino-acid can reconnect?

In contrast to DNA codons, which represent local information, harmony could represent holistic
information and characterize entire genes or their intronic portions.

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

http://tgdtheory.fi/public_html/articles/cfagain.pdf
http://tgdtheory.fi/public_html/articles/cfagain.pdf
https://en.wikipedia.org/wiki/Cellular_differentiation
https://en.wikipedia.org/wiki/Cellular_differentiation


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 74

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

1.2 Problem

There is however a problem. DNA codons coding for the same amino-acid correspond to different 3-chords
of harmony. One of these chords corresponds to amino-acid itself and the codons coding for amino-acid
correspond to the orbit of this chord under subgroup of isometries of icosahedron moving the triangles of
icosahedron along the orbit. This would apply also to mRNA and maybe also to tRNA. The chords at
the orbit of amino-acid are isomorphic (intervals are same) and obtained as transposes of each other.

The chords are isomorphic but not identical and this leads to the problem with resonance paradigm
unless one gives up the idea that amino-acid corresponds to a unique DNA codon and assumes that there
is analog of gauge invariance allowing to choose the preferred codon freely.

1. The assumption about preferred DNA codon could be given up if one can choose the preferred DNA
codon freely so that also the magnetic bodies of amino-acids are characterized by 3-chords and thus
carry information about what DNA codon coded them. This is possible if one has the analog of
fiber space structure with DNA codons coding for amino-acid defining the fiber and amino-acids
defining the base. This fiber structure with discrete gauge invariance is strongly suggestive and I
have proposed it for two decades ago but it seems that it poses strong conditions on the orbits of
the subgroups of isometries of icosahedron.

This condition is very restrictive. Simplifying somewhat: one considers 60 codons decomposing into
20+20+20 codings and each group of 20 codons codes for amino-acids belonging to different groups.
There are twenty of them. The 20 triangles of icosahedron correspond to 3 DNA codons each
and each of them corresponds to one and only one amino-acid. One has 3 subgroups of isometries
corresponding to 20+20+20 decomposition.

Can one perform a global gauge transformations realized as isometries and moving triangles along
the orbits of one of the 3 subgroups involved - say isometry g1 of G1? These transformations
would move the entire orbits of 2 subgroups involved - call them G2 and G3. What happens to
the chords of G2 and G3: is their character changed completely so that these harmonies would be
destroyed? It seems that this cannot work. Should one replace G2 and G3 with their automorphs
g1G2g

−1
1 and g1G3g

−1
1 . Does this make sense? 3-chords defining give orbit should be invariant

under automorphisms of Gi? This does not seem to be a realistic condition.

2. Could different automorphs correspond to different collections of chords physically just as global
gauge transformations generate different physical situations? Isometries of groups Gi would there-
fore define physically different realizations of bio-harmonies such that for each of them only one of
the DNA codons coding for given amino-acid could actually perform the coding. Ordinary genetic
code with many-to-one correspondence would make sense in statistical sense only. If this is true, the
cyclotron frequency 3-chord assignable to amino-acid depends on the DNA coding it and implies
physical distinctions.

3. One can consider also a third alternative. DNA codon with same 3-chord as coding for amino-acid
is in special role in that only it can resonate with the amino-acid! Could DNA codons codons
correspond to same cyclotron frequency triplet (magnetic fields) but different value of heff so
that one would have chord with respect to energy rather than frequency. Different values of heff

for DNA codons coding for the same amino-acid would scale their cyclotron frequencies to the
same amino-acid frequency while keeping cyclotron energies invariant? Cyclotron energy ratios for
codons correspond to rational valued ratios Ei/Ej = heff (i)/heff (j) = n(i)/n(j). Amino-acid
would correspond to fixed heff and this creates a problem: can DNA codon code for amino-acid
with different value of heff . This option does not look attractive.

Second option looks the most plausible one. Of course, it is early to talk about a prediction: it might
well be that I have mis-understood something.

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DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 75

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

2 How the notions of magnetic body and bio-harmony could
help to understand inheritance

Next more concrete ideas about magnetic body and bio-harmony in relation to epigenetics and inheritance
will be developed.

2.1 Questions about bio-harmony

One can pose a lot of questions about bio-harmony.

1. It is not necessary to assign any interpretation on the harmony. Just the harmony could be enough
if it is forced to be same for DNA, corresponding mRNA, tRNA, and aminoacids. One can however
make questions. Is the harmony inherited invariant and could it distinguish between different
personality types about which we learned in old books of psychology? Or could the harmonies
correlate with our own moods?

2. Could differentiation selecting particular genes as expressed genes apply also to harmonies so that
given gene would correspond only to a particular harmony and different copies of gene could cor-
respond to different harmonies. Could this selection rely on the same mechanisms as ordinary
differentiation realized in terms of epigenetic mechanisms and DNA editing? From the magnetic
bodies of genes the harmony would be automatically transferred to the magnetic bodies of mRNA,
tRNA and aminoacids since otherwise the transcription and translation do not work since magnetic
bodies do not have common resonance frequencies and reconnection and resonant interaction is not
possible.

3. Does given harmony characterize given gene or the entire cell? All basic biomolecules associated with
a gene would naturally correspond to the same harmony. If the rRNAs associated with ribosomes
are in harmony mutually cellular harmony seems to be the only option. If ribosomes have their
own harmonies, only certain ribosomes can translate given gene. This would bring in additional
control tool. The most plausible picture is that the situation depends on what happens in the
self-organization process. Some organs/organisms are more harmonious, others not so harmonious.
Harmony need not be given fixed to remain the same: magnetic body can have motor actions
changing the cyclotron frequencies. Moods could reflect the character of harmony at gene level.

4. Does magnetic body control the differentiation by posing restrictions on gene expression or vice
versa? The idea about magnetic body as intentional agent suggests that the first option is correct.
There would be hierarchy of magnetic bodies with magnetic bodies at the higher level controlling
bodies at the lower level. The value of Planck constant would label the hierarchy levels and also DNA
codons would be characterized by ”intelligence quotient” defined by heff/h. This would be nothing
but the analog for the hierarchy of program modules and I have earlier considered the realization
of this hierarchy (see http://tgdtheory.fi/public_html/articles/braidparse.pdf).

5. The selection of harmony could take place and be analogous to cell differentiation. This would be a
self-organization process in which magnetic bodies of genes, cells, etc.. tune themselves to resonance
with each other by modifying their magnetic fields by controlling their thickness (for monopoles
flux the flux is invariant). Something analogous to the development of social skills. This could pose
resonance as a constraint on processes like replication, transcription, reverse transcription, silencing,
enhancing, editing, etc.... It might induce the differentiation at gene level.

Editing processes for genome could be seen as being induced by the motor actions of the magnetic
body involving reconnection and change of the value of heff changing the length of the flux tube
and bringing biomolecules near to each other or separating them. This selection would also apply
to the intronic part of DNA proposed to be responsible for topological quantum computation like

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

http://tgdtheory.fi/public_html/articles/braidparse.pdf


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 76

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

processes. The copies of same fragment appearing in intronic portion and copies of genes could
correspond to different harmonies.

2.2 Can the notions of magnetic body and bio-harmony explain something
that ordinary genetic cannot?

It would be nice to identify some biological phenomenon difficult to understand in standard framework
but having an elegant explanation in terms of magnetic body.

1. The notion of harmony could manifest itself at the level of genes as different expressions for the
copies of same gene if they correspond to different notions of harmony. The copies of gene are
known as alleles (see https://en.wikipedia.org/wiki/Allele). The alleles can indeed give rise
to different phenotypic traits such as different pigmentation.

2. Morphogenesis provides examples of this kind of phenomena [2, 3, 4]. The first key idea is that DNA
and cell replication is induced by the replication of magnetic bodies serving as information carriers
(see http://tgdtheory.fi/public_html/tgdlian/tgdlian.html#lianPB) [8]. The second key
idea is that in zero energy ontology (ZEO) magnetic body is 4-dimensional and represents behavioral
patterns rather than only 3-dimensional patterns. For instance, memory as behavioral patterns can
be inherited by the piece of planaria worm not containing the brain. The explanation could be that
the magnetic body carries behavioral patterns replicated in the splitting of the worm.

3. Epigenetics studies changes of gene expression not caused by the change of DNA itself. Epigenome
(see https://en.wikipedia.org/wiki/Epigenome) is the highly dynamic part of DNA controlling
expression of the rather stable part of genome. One might regard stable part of genome as hard-
ware and epigenome as topological quantum computer programs assignable to magnetic body and
modifying gene expression epigenetically. Comment sign in computer code serves as a computer
scientific metaphor for epigenetic control by repression.

The modelling of epigenesis in terms of magnetic body and bio-harmonies deserves a separate discus-
sion.

1. The modification of transcription rate is the basic tool of epigenetic regulation. There are two
basic mechanisms involved. Histone modification (see https://en.wikipedia.org/wiki/Histone

affects the histones of chromatin so that the transcription is repressed or activated. Histone modifica-
tion takes place by several mechanisms. DNA methylation occurs for CpG pair and if it occurs for a
promoter region it represses the transcription and serves as a kind of gene lock. The degree of methy-
lation serves as a measure for the effectiveness of repression. I do not know whether the locking is ab-
solute at the level of single gene or whether only the transcription rate is reduced. Two mechanisms
are mentioned in the Wikipedia article (see https://en.wikipedia.org/wiki/DNA_methylation).
Methylation can impede geometrically some step in the transcription. Methylated site can be also
accompanied by proteins affecting histones in chromatin and in this manner impede transcription.

2. The notions of magnetic body and bio-harmony suggest an alternative - one might even hope funda-
mental - mechanism of repression. Methylation (histone modification) could affect some cyclotron
frequency associated with DNA codon (histone). In the optimal situation for transcription the DNA
and protein catalyzing the transcription or mRNA are in resonance. When cyclotron resonance con-
dition is not exactly satisfied, the reconnection rate for the U-shaped flux tubes associated with the
molecules involved in the process is reduced and also transcription is repressed.

I have considered also the radical possibility that the dynamics at the level of magnetic body
is fundamental for biology and that magnetic body defines templates for the bio-molecular self-
organization making dark matter dynamics visible. This is probably too extremist view and it

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

https://en.wikipedia.org/wiki/Allele
http://tgdtheory.fi/public_html/tgdlian/tgdlian.html#lianPB
https://en.wikipedia.org/wiki/Epigenetics
https://en.wikipedia.org/wiki/Epigenome
https://en.wikipedia.org/wiki/Histone
https://en.wikipedia.org/wiki/DNA_methylation


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 77

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

would seem that biochemistry affects the cyclotron frequencies assignable to the magnetic body by
affecting the strengths of magnetic fields also at dark magnetic flux tubes.

3. The notions of epigenetic code (see https://en.wikipedia.org/wiki/Epigenetic_code) and his-
tone code (see https://en.wikipedia.org/wiki/Histone_code) have been proposed. Epigenetic
code would consist of histone modifications and additional modifications such as DNA methyla-
tion. The codeword of the epigenetic code could code for some larger unit than protein: say gene
or entire cell. The hypothesis is that the chromatin-DNA interactions are induced by histone tail
modifications (such as methylation, acetylation, ADP-ribosylation, ubiquitination, citrullination,
and phosphorylation). There are 4 histones and the position of modification varies as well as the
modifier (the above modifications are not the only ones) so so that the number of modifications is
very large.

The addition of bioharmonies to the genetic information could simplify the situation dramatically
since the modifications could be seen as defining of of the 256 bio-harmonies with 64 chords each
(this for fixed scale which varies if the value of magnetic field strength is varied: biophoton spectrum
in visible is proposed to represent the range of values of magnetic field). The most plausible starting
hypothesis is that given harmony characterizes the gene. Much simpler option would be that the
harmony characterizes entire cell or even group of cells.

If the modification by kicking cyclotron frequency out of harmony is enough to repress transcription,
almost endless number of bio-chemical manners to achieve would exist but the epigenetic code could
be very simple at the basic level as TGD would predict. Each bio-harmony [?]harmonytheory [7]
would provide a representation of genetic code in terms of 3-chords predicting correctly the DNA-
amino-acid correspondence (there are actually two slightly differing codes explaining the presence
of 21st and 22nd amino-acid and deviations from the standard code). The states of dark protons
(or neutrons) are also proposed to realize genetic code [6, 5]: it is an open question whether these
codes imply each other as they should.

4. The understanding of transgenerational epigenetic inheritance (see https://en.wikipedia.org/

wiki/Transgenerational_epigenetic_inheritance) raises difficult challenges. One should un-
derstand how histone modification and DNA methylation are transferred to daughter cells in cellular
division or inherited by the offspring. Transgenerational interaction of the genomes seems necessary.
In TGD framework the interaction of magnetic bodies of via resonance mechanism could transfer
the epigenetic programs to the offspring. Offspring could ”learn” the epigenetic programs of the
mother by tuning.

5. Gregory Carey (see http://www.colorado.edu/ibg/people/61) gives nice real life examples about
the complexities of epigenesis identified quite generally as gene regulation (see http://tinyurl.

com/zb97cgs). He compares the gene regulation involved with the handling of a stressful situation
to ”nightmarish Rube Goldberg mousetrap” and sees the process as extremely ineffective from
engineering point of view. For instance, the hormones secreted to blood circulation are distributed
to the entire body. The whole thing could be carried out in brain! He also wonders why evolution
is so inefficient. All cells have same genome although most of the genes are silenced. Second strand
of DNA is totally un-used and most of DNA consists of introns. His explanation is that evolution
does not make long term plans but finds just a solution to a particular without thinking it from a
wider perspective: ”If it ain’t broke, don’t fix it”.

I tend to see this differently. If entire body is coherent quantum entity, engineering based thinking
does not make sense. Entire body and also magnetic body must be informed from the stress situation
since the reaction is holistic. The genes which are not used for gene expression might be used for
other purposes. Topological quantum computation could be this purpose in TGD framework and
repressed genes could be thus used for quantum information processing. Information processing
could be actually the dominating function of the DNA of higher vertebrates.

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

https://en.wikipedia.org/wiki/Epigenetic_code
https://en.wikipedia.org/wiki/Histone_code
https://en.wikipedia.org/wiki/Transgenerational_epigenetic_inheritance
https://en.wikipedia.org/wiki/Transgenerational_epigenetic_inheritance
http://www.colorado.edu/ibg/people/61
http://tinyurl.com/zb97cgs
http://tinyurl.com/zb97cgs


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 78

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

To sum up, magnetic body could be seen as the ”boss” controlling the gene expression and also the
evolution of genome in longer scales. Magnetic body would use bio-molecular mechanisms for its purposes.
This would bring in a new kind of inheritance: bio-harmony would be inherited. The most spectacular
almost-prediction would be that genetic code is many-to-one only in statistical sense.

2.3 RNA is transferred between soma cells and germ cells

The basic question of epigenesis is how the information between soma cells and germ cells is transferred.
In standard genetic the transfoer RNA or DNA molecules is necessary to achieve this. In TGD dark DNA,
RNA, tRNA, and aminocids consisting of dark nucleons realized as nuclear strings and accompanied by the
corresponding biomolecules is one possibility. The extremist view would be that the dynamics of the dark
variants of basic bio-molecules induces the dynamics of their molecular shadows making them only visible.
Also the transfer of information as cyclotron radiation can be considered in TGD framework and cyclotron
resonance could serve as a fundamental mechanism of epigenetic control. The above model suggest that
epigenetic control mechanisms rely on resonance mechanism for 3-chords associated with DNA codons
and other biomolecules giving them names is also at work besides purely geometrical silencing.

The popular article No Sex Required: Body Cells Transfer Genetic Info Directly Into Sperm Cells,
Amazing Study Finds (see http://tinyurl.com/hhdth5j) summarizing the findings discussed in the
article [1] (see Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells:
Possible Transport by Exosomes (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081593/) as
very interesting concerning this basic question.

The abstract of the article gives for a professional a readable summary.
Mendelian laws provide the universal founding paradigm for the mechanism of genetic inheritance

through which characters are segregated and assorted. In recent years, however, parallel with the rapid
growth of epigenetic studies, cases of inheritance deviating from Mendelian patterns have emerged. Grow-
ing studies underscore phenotypic variations and increased risk of pathologies that are transgenerationally
inherited in a non-Mendelian fashion in the absence of any classically identifiable mutation or predis-
posing genetic lesion in the genome of individuals who develop the disease. Non-Mendelian inheritance
is most often transmitted through the germline in consequence of primary events occurring in somatic
cells, implying soma-to-germline transmission of information. While studies of sperm cells suggest that
epigenetic variations can potentially underlie phenotypic alterations across generations, no instance of
transmission of DNA- or RNA-mediated information from somatic to germ cells has been reported as yet.

To address these issues, we have now generated a mouse model xenografted with human melanoma
cells stably expressing EGFP-encoding plasmid. We find that EGFP RNA is released from the xenografted
human cells into the bloodstream and eventually in spermatozoa of the mice. Tumor-released EGFP RNA
is associated with an extracellular fraction processed for exosome purification and expressing exosomal
markers, in all steps of the process, from the xenografted cancer cells to the spermatozoa of the recipient
animals, strongly suggesting that exosomes are the carriers of a flow of information from somatic cells
to gametes. Together, these results indicate that somatic RNA is transferred to sperm cells, which can
therefore act as the final recipients of somatic cell-derived information.

Some background is needed to understand this rather technical summary.

1. Darwinism has dominated biology since Darwin. The rules of classical Mendelian inheritance con-
form with the Darwinian view and can be reduced to genetic level. Various traits are inherited
genetically by sexual reproduction and genome would change during lifetime only through mu-
tations. Genome changes exremely slowly by random changes for offspring from which selection
pressures choose the survivors.

Lamarckian view in turn assumed that the external circumstances experienced by organism leave
a trace, which can be inherited but it could not be formulated in terms of modern molecular
biology whereas the Darwinian dogma could be formulated in terms of Weissman’s genetic barrier.
Information flows from germ cells to soma but never in opposite direction. If it would do so, the

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

http://tinyurl.com/hhdth5j
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081593/


DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 79

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

soma interacting with environment could transfer information to germ cells and the experiences
during lifetime could leave inheritable trace to germ cells.

An analogous dogma is that information is always transcribed from DNA to RNA to proteins but
never in opposite direction. It is now known that this takes place in case of viruses and retroviruses:
there are so called jumping genes which can also make copies of themselves. 5 per cent of human
genome conists of endogenous retroviruses capable of doing the same. The huge genome of maize
is due to this kind of proces.

2. The development epigenetics has started to shatter the belief on Wessimann’s genetic barrier. Gene
expression is not fixed by genome alone and can be change even when genes are unaffected. Silencing
of genes by DNA methylation and histone modification allow to modify gene expression. Silencing
is essentially a locking of gene preventing its expression by transcription followed by translation.

It is now known that epigenetic changes in the gene expression can be inherited. The mechanisms
are still poorly understood. What seems however clear the genome is more like a slowly changing
hardware and gene expression or whatever is behind it is the software and programs can change
very rapidly by just adding or deleting comment signs in the code. A deeper understanding of this
software is needed.

3. Epigenetic inheritance requires that genetic information is transferred from soma cells to germ cells.
If only DNA or RNA are capable of representing genetic information, then DNA or RNA must be
transferred from soma cells to germ cells. No instance of direct DNA or RNA mediated information
from soma to germ cells had been observed before the above mentioned experiments. One can
of course challenge the assumption about DNA and RNA as the only representations of genetic
information.

The basic idea of the experiment was simple. Use a marker for RNA by using plasmids (DNA strands
not belonging to chromosomes) genetically engineered to code for a marker protein making itself visible
by fluoresence. Then one just follows the fate of these proteins generated in soma cells and looks whether
they end up inside germ cells and how this happens.

More technically: mouse model was xenografted with human melanoma cells stably expessing EGFP-
coding plasmid (expressed in a manner possibly evoking emotions: human melanoma cancer tissue was
implanted in mouse). EGFP-RNA is released from xenografted human cells to blood. One just looks
whether it eventually ends up to the sperm cells of mice and tries to identify the transfer mechanism.
Only transfer to sperm cells was studied. One might expect that the transfer of RNA can happen also to
ovum. I guess that the sperm cells are easier to study.

What was observed?

1. The transfer of RNA from soma cells to sperm cells was indeed found to occur. The transferred
RNA can in turn induce epigenetic effects in germ cells known to be inherited by a mechanisms,
which however remain poorly understood. Epigenetic mechanisms seem to be involved in the cases
considered so that DNA is not changed, only its expression.

2. The transfer mechanism was identified. The transferred RNA is contained by exosomes analogous
to synaptic vesicles transferring neurotransmitters from presynaptic to postsynaptic cell. Transfer
of RNA takes place via fusion of the membranes just like transfer of neurotransmitters. Maybe
genetic engineering using exosomes or analogous structures to transfer the needed material to cells
has been tried.

The implications of the findings are dramatic but already implied by the earlier work in epigenet-
ics. What is important that Lamarckian view can be now defended by a concrete genetic mechanism.
Lamarckism implies that the time scale of inheritance becomes the time scale for the appearence of a
new generation. Nutrition, environment, lifestyle and even meditation and similar practices, are already

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

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DNA Decipher Journal | March 2016 | Volume 6 | Issue 1 | pp. 72-80 80

Pitkänen, M., On Magnetic Body, Bio-harmonies, Morphogenesis & Epigenetics

now known to affect gene expression on daily basis: we are not victims of genetic determinism and are
epigenetically responsible for our own well-being. Epigenetic information can be transferred also to germ
cells so that we responsible also for the well-being of our children. Our children suffer our sins and share
our sufferings.

The precise mechanism of inheritance of epigenetic modifications remains still poorly understood
although it seems that the transfer or RNA to germ cells occurs. There are also other hints: it is known
that alleles (variants of game gene) can express themselves differently. One allele can also induce other
allele to express in the same manner. Somekind of ”social pressure” like interaction seems to be involved.

As explained, TGD suggests the notion of magnetic body and cyclotron resonance as this interaction.
The DNA of offspring get tuned to the DNA of mother during pregnancy and this gives to epigenetic
inheritance. Various epigenetic mechanisms such as methylation and histone modification could affect
cyclotron frequencies besides purely geometric modifications of DNA and locking at the level of gene
could be accompanied kicking out of tune at the level of magnetic body. In this framework the transfer
of RNA to germ cells would be necessary to affect the cyclotron frequencies.

References

[1] Cossetti C et al. Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour
Cells: Possible Transport by Exosomes. Plos One.Available at: http://www.ncbi.nlm.nih.gov/

pmc/articles/PMC4081593/ , 9, 2014.

[2] Levin M. The wisdom of the body: future techniques and approaches to morphogenetic fields
in regenerative medicine, developmental biology and cancer. Regen Med . Available at: http:

//www.futuremedicine.com/doi/pdf/10.2217/rme.11.69, 6(6):667–673, 2011.

[3] Levin M. Morphogenetic fields in embryogenesis, regeneration, and cancer: Non-local control of
complex patterning. Biosystems. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22542702,
109(3):243–261, 2012.

[4] Levin M Somrat T. An automated training paradigm reveals long-term memory in planarians and its
persistence through head regeneration. The J Experimental Biology. Available at: http://tinyurl.
com/ntlxpep, 216:3799–3810, 2013.

[5] Pitkänen M. Homeopathy in Many-Sheeted Space-Time. In Bio-Systems as Conscious Holo-
grams. Onlinebook. Available at: http://tgdtheory.fi/public_html/hologram/hologram.html#
homeoc, 2006.

[6] Pitkänen M. Nuclear String Hypothesis. In Hyper-finite Factors and Dark Matter Hierar-
chy. Onlinebook. Available at: http://tgdtheory.fi/public_html/neuplanck/neuplanck.html#
nuclstring, 2006.

[7] Pitkänen M. Quantum Model for Hearing. In TGD and EEG. Onlinebook. Available at: http:

//tgdtheory.fi/public_html/tgdeeg/tgdeeg/tgdeeg.html#hearing, 2006.

[8] Pitkänen M. Quantum Mind, Magnetic Body, and Biological Body. In TGD based view about living
matter and remote mental interactions. Onlinebook. Available at: http://tgdtheory.fi/public_

html/tgdlian/tgdlian.html#lianPB, 2012.

[9] Pitkänen M. Geometric theory of harmony. Available at: http://tgdtheory.fi/public_html/

articles/harmonytheory.pdf, 2014.

ISBN: ISSN: 2159-046X DNA Decipher Journal www.www.dnadecipher.com

Published by QuantumDream, Inc.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081593/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081593/
http://www.futuremedicine.com/doi/pdf/10.2217/rme.11.69
http://www.futuremedicine.com/doi/pdf/10.2217/rme.11.69
http://www.ncbi.nlm.nih.gov/pubmed/22542702
http://tinyurl.com/ntlxpep
http://tinyurl.com/ntlxpep
http://tgdtheory.fi/public_html/hologram/hologram.html#homeoc
http://tgdtheory.fi/public_html/hologram/hologram.html#homeoc
http://tgdtheory.fi/public_html/neuplanck/neuplanck.html#nuclstring
http://tgdtheory.fi/public_html/neuplanck/neuplanck.html#nuclstring
http://tgdtheory.fi/public_html/tgdeeg/tgdeeg/tgdeeg.html#hearing
http://tgdtheory.fi/public_html/tgdeeg/tgdeeg/tgdeeg.html#hearing
http://tgdtheory.fi/public_html/tgdlian/tgdlian.html#lianPB
http://tgdtheory.fi/public_html/tgdlian/tgdlian.html#lianPB
http://tgdtheory.fi/public_html/articles/harmonytheory.pdf
http://tgdtheory.fi/public_html/articles/harmonytheory.pdf

	Introduction
	The notions of 4-D magnetic body and bio-harmony
	Problem

	How the notions of magnetic body and bio-harmony could help to understand inheritance
	Questions about bio-harmony
	Can the notions of magnetic body and bio-harmony explain something that ordinary genetic cannot?
	RNA is transferred between soma cells and germ cells


