item: #1 of 101
          id: dti-1294
      author: Pan, Xing Qing; Jones, Susie; Cox, Karen
       title: The Way that PEGyl-DSPC Liposomal Doxorubicin Particles Penetrate into Solid Tumor Tissue
        date: 2006-01-01
       words: 4158
      flesch: 58
     summary: It is agreeable, the amount of liposomal particles can penetrate into solid tumor tissue is determined by the hole size and number of the blood vessels, but not deter- mined by the targeting group which located on the liposomal particle surface. No obvious differences could be pointed out in Figure between the non-targeted liposome and folic acid targeted liposome, only the diffusion of the folic acid targeted liposomal particles looked faster.
    keywords: blood; cells; doxorubicin; drug; liposomal; liposome; particles; tissue; tumor
       cache: dti-1294.pdf
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        item: #2 of 101
          id: dti-1295
      author: Stief, Thomas W.
       title: Inhibition of Intrinsic Thrombin Generation
        date: 2006-01-01
       words: 3044
      flesch: 61
     summary: There are several clinically used inhibitors of intrinsic thrombin generation. The effi ciency of any anticoagulant on intrinsic thrombin generation should be measured for each individual patient.
    keywords: arginine; inca; min; plasma; thrombin
       cache: dti-1295.pdf
  plain text: dti-1295.txt

        item: #3 of 101
          id: dti-1296
      author: Kitanaka, Junichi; Kitanaka, Nobue; Takemura, Motohiko
       title: Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions
        date: 2006-01-01
       words: 9172
      flesch: 63
     summary: Yasar, S. et al. 1993. Aubin, N. et al. 2004.
    keywords: amphetamine; clorgyline; dopamine; et al; inhibitors; kitanaka; mao; meth; methamphetamine; mice; monoamine; pharmacol; selegiline
       cache: dti-1296.pdf
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        item: #4 of 101
          id: dti-1297
      author: Taupin, Philippe
       title: Neurogenesis and Alzheimer's Disease
        date: 2006-01-01
       words: 2776
      flesch: 58
     summary: These results show that drugs used to treat AD increase neurogenesis in the adult brain, which may contribute to their therapeutic effects (Jin et al. 2006). Wen, P.H., Shao, X. and Shao, Z. et al. 2002.
    keywords: adult; brain; cells; et al; neurogenesis
       cache: dti-1297.pdf
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        item: #5 of 101
          id: dti-1298
      author: Taupin, Philippe
       title: Neurogenesis and the Effect of Antidepressants
        date: 2006-01-01
       words: 3871
      flesch: 52
     summary: Mol. Psychiatry, 5:262–9. Kessler, R.C., McGonagle, K.A. and Zhao, S. et al. 1994. Kuhn, H.G., Winkler and J. Kempermann, G. et al. 1997.
    keywords: adult; antidepressants; brain; cells; depression; et al; hippocampal; neurogenesis
       cache: dti-1298.pdf
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        item: #6 of 101
          id: dti-1299
      author: Di Iorio, Biagio R.; Guastaferro, Pasquale; Cillo, Nicola; Cucciniello, Emanuele; Bellizzi, Vincenzo
       title: Long-term L-Carnitine Administration reduces Erythropoietin Resistance in Chronic Hemodialysis Patients with Thalassemia Minor
        date: 2007-01-01
       words: 3830
      flesch: 61
     summary: It has been demonstrated that carnitine administration in dialysis patients improves the management of anemia and reduces the erythropoietin resistance (11–12). The American Association of Kidney Patients Consensus Group concluded there is a defi nite role for carnitine in dialysis patients, particularly for certain conditions that do not adequately respond to the standard therapy (34).
    keywords: administration; anemia; carnitine; dialysis; epo; erythropoietin; hemodialysis; patients; thal
       cache: dti-1299.pdf
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        item: #7 of 101
          id: dti-1300
      author: Guterres, Sílvia S.; Alves, Marta P.; Pohlmann, Adriana R.
       title: Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications
        date: 2007-01-01
       words: 7911
      flesch: 60
     summary: The types of those systems are nanospheres (Shim et al. 148 Guterres et al Drug Target Insights 2007: 2 2004), nanocapsules (Alvarez-Román et al. 2001; Milão et al. 2003; Miyazaki et al. 2003; Alvarez- Román et al. 2004a; Alvarez-Román et al. 2004b; Müller-Goymann, 2004; Shim et al. 2004), nano- emulsion (Calvo et al. 1996; Müller-Goymann, 2004; Sonneville-Aubrun et al. 2004; Yilmaz and Borchert, 2005), solid lipid nanoparticles (Jenning et al. 2000a; Jenning et al. 2000b; Lippacher et al. 2001; Mehnert and Mäder, 2001; Müller et al. 2002; Wissing and Müller, 2002a; Wissing and Müller, 2002b; Wissing and Müller, 2002c), micro- emulsions (Kreilgaard, 2002), liposomes (Barratt, 2000; Maghraby et al. 2000; Verma et al. 2003; Fang et al. 2006) and niosomes (Shahiwala and Misra, 2002). The presence of oil in the nano- capsules leads to a vesicular structure while its absence in nanospheres provide a matricial orga- nization of the polymeric chains (Soppimath et al. 2001; Couvreur et al. 2002; Schaffazick et al. 2003).
    keywords: 2001; control; corneum; drug; et al; formulations; int; j. pharm; müller; nanocapsules; nanoparticles; omc; penetration; pharm; release; skin; stratum; systems
       cache: dti-1300.pdf
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        item: #8 of 101
          id: dti-1301
      author: Hamman, J.H.; Demana, P.H.; Olivier, E.I.
       title: Targeting Receptors, Transporters and Site of Absorption to Improve Oral Drug Delivery
        date: 2007-01-01
       words: 8045
      flesch: 54
     summary: Keywords: Oral drug delivery, absorption enhancement, receptor-mediated endocytosis, active transporters, site-specifi c drug delivery. Overcoming these barriers is currently one of the most challenging goals in oral drug delivery (Majumdar and Mitra, 2006; Leonard et al. 2006; Hamman et al. 2005; Ghilzai, 2004).
    keywords: absorption; acid; cell; delivery; drug; drug delivery; endocytosis; et al; intestine; membrane; receptor; systems; target; targeted; tract; transferrin; transporters; vitamin
       cache: dti-1301.pdf
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        item: #9 of 101
          id: dti-1302
      author: Hamre, Harald J.; Glockmann, Anja; Fischer, Michael; Riley, David S.; Baars, Erik; Kiene, Helmut
       title: Use and Safety of Anthroposophic Medications for Acute Respiratory and Ear Infections: A Prospective Cohort Study
        date: 2007-01-01
       words: 8437
      flesch: 63
     summary: Patients with medication Different medications Applications Medication AMED Non-AM All AMED Non-AM All AMED Non-AM All A) Ongoing at study entry, 75 78 125 94 59 153 8,656 3,576 12,232 used Day 0–28 B) Prescribed at Day 0 715 255 715 223 76 299 59,090 3,842 62,932 C) This ADR has not been reported to the manu- facturer previously, but has been observed repeatedly in other patients by the boy’s physician.
    keywords: adr; aes; amed; analysis; medication; patients; relationship; safety; study
       cache: dti-1302.pdf
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        item: #10 of 101
          id: dti-1304
      author: Kameda, Hideto; Suzuki, Miyuki; Takeuchi, Tsutomu
       title: Platelet-Derived Growth Factor as a Therapeutic Target for Systemic Autoimmune Diseases
        date: 2007-01-01
       words: 6647
      flesch: 51
     summary: Arthritis Rheum., 41:1979–86. Johnson, R.J., Raines, E.W., Floege, J. et al. 1992. Matsuda, M., Shikata, K., Makino, H. et al. 1997.
    keywords: arthritis; brosis; cells; diseases; et al; factor; growth; imatinib; inhibition; kameda; patients; pdgf; rheumatoid; treatment
       cache: dti-1304.pdf
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        item: #11 of 101
          id: dti-1305
      author: Khan, M. Omar F.
       title: Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design
        date: 2007-01-01
       words: 11421
      flesch: 56
     summary: Benson, T.J., McKie, J.H., Garforth, J. et al. 1992. Hunter, W.N., Bailey, S., Habash, J. et al. 1992.
    keywords: activity; agents; chem; compounds; cruzi; design; drug; enzyme; et al; fairlamb; h n; inhibition; inhibitors; khan; med; n n; reductase; site; structure; substrate; target; trypanosoma; trypanothione; trypanothione reductase
       cache: dti-1305.pdf
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        item: #12 of 101
          id: dti-1306
      author: N.S, Ningaraj; B.P, Salimath; U.T, Sankpal; R, Perera; T, Vats
       title: Targeted Brain Tumor Treatment-Current Perspectives
        date: 2007-01-01
       words: 8102
      flesch: 51
     summary: Therefore, understanding the biochemical regulation of the BBB (Fig. 1) in normal and tumor-invaded brain is of great importance to develop therapeutics that breach or circumvent BBB and directly target brain tumor cells (Ningaraj, 2006). The potential of anti-angiogenic therapy in human brain tumors is demonstrated in experimental brain tumor models.
    keywords: brain; brain tumor; cancer; cells; channels; delivery; dna; drug; et al; expression; gene; glioma; growth; inhibitors; molecular; ningaraj; patients; res; target; therapy; treatment; tumor
       cache: dti-1306.pdf
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        item: #13 of 101
          id: dti-1307
      author: Ohlsson, Bodil; Janciauskiene, Sabina
       title: New Insights into the Understanding of Gastrointestinal Dysmotility
        date: 2007-01-01
       words: 7255
      flesch: 55
     summary: Chronic intestinal pseudo-obstruction (CIPO) is the most diffi cult of these clinical challenges, characterised by the presence of chronic dys- motility and intestinal dilatation in the absence of mechanical obstruction (De Giorgio et al. 2004a). GIP = gastric inhibitory polypeptide; GLP-1 = glucagon-like peptide 1; GnRH = gonadotropin-releasing hormone; PP = pancreatic polypeptide; TRH = thyrotropin-releasing hormone; VIP = vasoactive intestinal peptide. 231 Gastroinestinal motility Drug Target Insights 2007:2 (i.e. Hirschsprung’s disease) to intestinal or extra intestinal diseases (i.e. ulcerative colitis and Crohn`s disease, amyloidosis, scleroderma and etc) (Di Lorenzo, 1999; De Giorgio and Camilleri, 2004b; De Giorgio et al. 2004c).
    keywords: bowel; cells; disease; enteric; et al; gastric; gastrointestinal; gnrh; hormone; human; motility; neurons; ohlsson; oxytocin; patients; role; system; tract
       cache: dti-1307.pdf
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        item: #14 of 101
          id: dti-1308
      author: Okubo, Yasunori; Kusumoto, Kenji; Bessho, Kazuhisa
       title: Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
        date: 2007-01-01
       words: 4512
      flesch: 60
     summary: In the control group, trabecular bone tissue was observed at the outer edge of the implanted material. Yamamoto, I., Morita, R. and Fukunaga, M. et al. 1981.
    keywords: activity; bone; group; hbo; implantation; rhbmp-2
       cache: dti-1308.pdf
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        item: #15 of 101
          id: dti-1309
      author: Panossian, Alexander; Hambardzumyan, Marina; Hovhanissyan, Areg; Wikman, Georg
       title: The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol
        date: 2007-01-01
       words: 11404
      flesch: 61
     summary: Ohkura, Y., Mizoguchi, Y. and Morisawa, S. et al. 1990. Typically these adaptogens prevent or at least decrease certain hormonal changes, such as the increased level of cortisone, that are char- acteristic of a stress reaction (Panossian et al. 1999b; Kim et al. 2003a).
    keywords: adaptogens; animals; blood; cortisol; drug; effects; et al; jnk; levels; panossian; rosea; sapk; stress; study
       cache: dti-1309.pdf
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        item: #16 of 101
          id: dti-1310
      author: Konstantinopoulos, Angelis; Giannitsas, Konstantinos; Raptis, Spiros; Perimenis, Petros
       title: Endothelial Dysfunction, Erectile Dysfunction and Phosphodiesterase 5 Inhibitors. An Update of the Current Data and Future Perspectives
        date: 2007-01-01
       words: 5379
      flesch: 48
     summary: Montorsi, P., Ravagnani, P.M., Galli, S. et al. 2004. Rosen, R.C., Riley, A., Wagner, G. et al. 1997.
    keywords: artery; cells; cgmp; disease; dysfunction; endothelial; et al; heart; muscle; sildenafi; smooth; vascular
       cache: dti-1310.pdf
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        item: #17 of 101
          id: dti-1311
      author: Abdel-Salam, Omar M.E.
       title: Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine
        date: 2007-01-01
       words: 7313
      flesch: 60
     summary: Thus, the effect of co-administration of the alpha-2 adrenoreceptor antagonist yohimbine (5 mg/kg, i.p.), the beta adrenoreceptor antagonist, propranolol (2 mg/kg, i.p.), the muscarinic acetyl- choline receptor antagonist atropine (2 mg/kg, i.p.), the non-selective opioid receptor antagonist naloxone (5 mg/kg, i.p.), the non-selective adenosine receptor antagonist theophylline (20 mg/kg, i.p.), the GABA agonist baclofen (5 mg/kg, i.p.), and the potassium channel blocker glibenclamide (5 mg/ kg, i.p.), indomethacin (5 mg/kg, i.p.) were exam- ined on antinociception caused by cinnarizine. Furthermore, the effect of the centrally acting dopamine D2 receptor antagonists, sulpiride (10 mg/kg, i.p.) and haloperidol (1.5 mg/kg, i.p.), the peripherally acting D2 receptor antagonist domperidone (10 mg/kg, i.p.) or D2 receptor agonist bromocryptine (3 mg/kg, i.p.), the D2 receptor antagonist metoclopramide (10 mg/kg) and the non-selective dopamine receptor antago- nist chlorpromazine (3 mg/kg, i.p.) was examined.
    keywords: antagonist; antinociception; cinnarizine; control; dopamine; drug; effect; et al; gastric; i.p; mice; receptor
       cache: dti-1311.pdf
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        item: #18 of 101
          id: dti-1312
      author: Salam, Omar M.E. Abdel; Sleem, Amany A.; Omara, Enayat A.; Hassan, Nabila S.
       title: Effect of Ribavirin Alone or Combined with Silymarin on Carbon Tetrachloride Induced Hepatic Damage in Rats
        date: 2007-01-01
       words: 6897
      flesch: 57
     summary: Others, however, failed to demonstrate such benefi t from silymarin (Trinchet et al. 1989; Buzzelli et al. 1993). (D) A photomicrograph from a section of rat liver given CCl4 with ribavirin at 90 mg/kg, showing moderate improvement in protein content in liver cells (Bromophenol blue reaction × 300).
    keywords: ccl4; chronic; et al; hepatic; hepatitis; liver; patients; pcna; rats; ribavirin; serum; silymarin
       cache: dti-1312.pdf
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        item: #19 of 101
          id: dti-1313
      author: Nishida, Seiichiro; Satoh, Hiroyasu
       title: Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions
        date: 2007-01-01
       words: 4619
      flesch: 54
     summary: Pharmacology of sinomenine, an anti-rheumatic alka- loids from sinomenine acutum. Its main constituent of Sinomenine acutum is sinomenine, which has also used for clinical treatment of Rheumatoid arthritis (RA), due to the anti-infl ammatory and immunomodulative actions (Yamasaki, 1976; Liu et al. 1996).
    keywords: actions; acutum; ca2; satoh; sinomenine
       cache: dti-1313.pdf
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        item: #20 of 101
          id: dti-1314
      author: Savaraj, Niramol; Wu, Chunjing; Kuo, Marcus Tien; You, Min; Wangpaichitr, Medhi; Robles, Carlos; Spector, Seth; Feun, Lynn
       title: The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
        date: 2007-01-01
       words: 6233
      flesch: 64
     summary: However, induction of ASS expression does occur which results in resistance to ADI -PEG20. We have used 4 melanoma cell lines to study factors which may govern ASS expression.
    keywords: a2058; a375; adi; arginine; ass; cell; et al; expression; lane; lines; media; melanoma; peg20
       cache: dti-1314.pdf
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        item: #21 of 101
          id: dti-1317
      author: Stief, Thomas W.
       title: Phospholipase A2 Activates Hemostasis
        date: 2007-01-01
       words: 7213
      flesch: 63
     summary: Zander, K., Sherman, M.P., Tessmer, U., Bruns, K., Wray, V., Prechtel, A. T., Schubert, E., Henklein, P., Luban, J. and Neidleman, J. et al. 2003. From the results, the hypothesis was proposed by Luban et al. that CA binding by CyPA prevented normal anti- viral effects mediated by TRIM5α during HIV-1 infection of human cells, but this same interaction mediated HIV-1 restriction in nonhuman primate cells (Sokolskaja et al. 2006; Luban, in press).
    keywords: 2005; activity; binding; cells; csa; cyclophilin; cypa; cypb; et al; genome; hcv; human; protein; replication; rna; virus
       cache: dti-1317.pdf
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        item: #22 of 101
          id: dti-1318
      author: Wapling, Johanna; Srivastava, Seema; Shehu-Xhilaga, Miranda; Tachedjian, Gilda
       title: Targeting Human Immunodeficiency Virus Type 1 Assembly, Maturation and Budding
        date: 2007-01-01
       words: 19716
      flesch: 60
     summary: The C-terminal domain of Gag in the context of Gag-Pol is essential for its interaction with Gag and its incorporation into the virion (Srinivasakumar et al. 1995; Chiu et al. 2002; Chien et al. 2006). However, the magni- tude of the virion incorporation defect of Gag-Pol MHR deletion mutants varies between different studies making the value of targeting this region of Gag-Pol unclear with respect to inhibition of the late stages of HIV-1 replication (Mammano et al. 1994; Srinivasakumar et al. 1995; Chiu et al. 2002; Chien et al. 2006).
    keywords: 1996; 1998; 2000; 2003; 2005; acid; activity; assembly; cell; ciency; ciency virus; dimerization; domain; drug; et al; gag; hiv-1; host; human; immunodefi; inhibition; inhibitors; maturation; particle; peptide; pol; protease; protein; replication; targeting; transcriptase; type; virol; virus; virus type; vpu
       cache: dti-1318.pdf
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        item: #23 of 101
          id: dti-1319
      author: R.R, Resende; H.A.M, Torres; K.K, Yuahasi; P, Majumder; H, Ulrich
       title: Delivery Systems for In Vivo Use of Nucleic Acid Drugs
        date: 2007-01-01
       words: 10916
      flesch: 57
     summary: This research group constructed a vector containing the theophylline- binding aptamer (Jenison et al. 1994; This suggested that miRNAs block translation elongation or termination rather than translational initiation (Olsen and Ambros, 1999; Seggerson et al. 2002).
    keywords: activity; aptamer; binding; cancer; cells; delivery; dna; drug; et al; expression; gene; interference; molecules; mrna; nucleic; protein; rna; rnai; sci; silencing; sirna; small; specifi; target; ulrich; vitro; vivo
       cache: dti-1319.pdf
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        item: #24 of 101
          id: dti-1320
      author: Nysoeter, Gunnar; Erichsen, Kari; Milde, Anne Marita; Colás, Eva; Kristoffersen, Einar; Berstad, Arnold
       title: Effect of live Salmonella Ty21a in Dextran Sulfate Sodium-induced Colitis
        date: 2007-01-01
       words: 4473
      flesch: 58
     summary: Control Ty21a DSS DSS − Ty21a 0 1 2 3 4 Control Ty21a DSS DSS + Ty21a 0 1 2 3 P > 0.05 P > 0.05 C ry p t sc o re In fl a m m a to ry s co re 227 Effect of Salmonella Ty21a on experimental colitis Drug Target Insights 2007:2 vaccination with Salmonella Ty21a in humans with IBD is safe. For further information go to: http://creativecommons.org/licenses/by/3.0/. Effect of live Salmonella Ty21a in Dextran Sulfate Sodium-induced Colitis Gunnar Nysœter1, Kari Erichsen2, Anne Marita Milde3, Eva Colás4, Einar Kristoffersen5 and Arnold Berstad6 1Department of Medicine, Section for Gastroenterology, 2Children’s Clinic, 3Department of Biological and Medical Psychology, 4Innovest,5Section for Microbiology and Immunology, Haukeland University Hospital, Bergen, Norway, 6Institute of Medicine, University of Bergen, Norway.
    keywords: ammatory; animals; colitis; disease; dss; group; infl; rats; salmonella; study; ty21a; vaccine
       cache: dti-1320.pdf
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        item: #25 of 101
          id: dti-1321
      author: Erkut, Bilgehan; Özyazıcıoğlu, Ahmet; Karapolat, Bekir Sami; Koçoğulları, Cevdet Uğur; Keles, Sait; Ateş, Azman; Gundogdu, Cemal; Kocak, Hikmet
       title: Effects of Ascorbic Acid, Alpha-Tocopherol and Allopurinol on Ischemia-Reperfusion Injury in Rabbit Skeletal Muscle: An Experimental Study
        date: 2007-01-01
       words: 6501
      flesch: 56
     summary: Abstract Purpose: Ischemia reperfusion injury to skeletal muscle, following an acute arterial occlusion is important cause of morbid- ity and mortality. The aim of the present study was to determine and evaluate the effects of ascorbic acide, alpha-tocopherol and allopurinol on ischemia reperfusion injury in rabbit skeletal muscle.
    keywords: acide; allopurinol; antioxidant; ascorbic; group; injury; ischemia; levels; muscle; reperfusion; reperfusion injury; study; tissue; tocopherol; treatment
       cache: dti-1321.pdf
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        item: #26 of 101
          id: dti-1322
      author: Chiang, Thomas M.; Woo-Rasberry, V.
       title: The Toxicity of a Chemically Synthesized Peptide Derived from Non-Integrin Platelet Collagen Receptors
        date: 2008-08-13
       words: 4833
      flesch: 58
     summary: cHyB inhibits type I collagen-induced platelet aggregation. In addition, we have characterized the platelet receptor for type III collagen and defi ned two active peptides in its sequences (Chiang et al. 2002).
    keywords: aggregation; cells; chyb; collagen; effect; iii; peptide; platelet; rat; type
       cache: dti-1322.pdf
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        item: #27 of 101
          id: dti-1323
      author: Debouzy, Jean-Claude; Crouzier, David; Lefebvre, Bertrand; Dabouis, Vincent
       title: Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect
        date: 2008-05-28
       words: 7294
      flesch: 56
     summary: SLO antioxidant properties are also of interest: hence, vitamin E is routinely used as adjuvant agent in radiotherapy, used for its antiradical properties in the prevention of radio induced fi brosis Superfi cial tension (dG-G°, mN/m), 298 K as a function of SLO concentration (mg/mL) (•), and percentage of haemolysis fol- lowing the concentration of SLO (• ).
    keywords: dmpc; esr; figure; membrane; nmr; oil; properties; slo; spectrum; spin; temperature; water
       cache: dti-1323.pdf
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        item: #28 of 101
          id: dti-1324
      author: Nysæter, Gunnar; Berstad, Arnold
       title: Live Typhoid Vaccine for IBD-Patients–-Well Tolerated and with Possible Therapeutic Effect
        date: 2008-05-16
       words: 3490
      flesch: 53
     summary: After this she has continued to take oral typhoid vaccine about once a year for the last 9 years, being convinced of the vaccine’s positive effect on her ulcerative colitis. The symptomatic and endoscopic improvements were not dramatic, but encouraging enough to warrant further studies on the potential therapeutic effect of live typhoid vaccine on patients with IBD.
    keywords: colitis; disease; effect; ibd; infl; live; patients; symptoms; typhoid; vaccine
       cache: dti-1324.pdf
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        item: #29 of 101
          id: dti-1325
      author: Woo-Rasberry, Virginia; Chiang, Thomas M.
       title: The Beta3 499–513 Peptide Region is Required for AlphaIIb/Beta3 Active Complex Formation and Fibrinogen Binding
        date: 2008-04-28
       words: 6545
      flesch: 61
     summary: In order to study the effects of P4 (wild type β3) on the formation of active αIIb/β3, we have engineered a construct containing the scrambled sequence of the active peptide (P4s) in β3 cDNA. The binding capacity of AP2 (calculated as percentage gated subset) was similar between 71 The beta3 499–513 peptide region is required for alphaIIb/beta3 active complex Drug Target Insights 2008:3 wild type β3 and β3-mut.
    keywords: binding; brinogen; cells; complex; mut; peptide; type; αiib
       cache: dti-1325.pdf
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        item: #30 of 101
          id: dti-1326
      author: Fernandez, Hubert H.; McCown, Katie M.; Romrell, Janet; Trieschmann, Martha E.; Friedman, Joseph H.; Jacobson IV, Charles E.; Okun, Michael S.
       title: New-Onset Diabetes Mellitus among Parkinsonian Patients Treated with Long-term Quetiapine
        date: 2008-03-18
       words: 2384
      flesch: 55
     summary: To determine true prevalence, patients with previous and recent diagnoses of DM, and/or use of hypo- glycemic agents prior to quetiapine initiation were included. This study examined the risk of developing new-onset DM among parkinsonian patients on long-term, low dose quetiapine.
    keywords: diabetes; parkinsonian; patients; prevalence; quetiapine
       cache: dti-1326.pdf
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        item: #31 of 101
          id: dti-1327
      author: Viola-Villegas, Nerissa; Vortherms, Anthony; Doyle, Robert P.
       title: Targeting Gallium to Cancer Cells through the Folate Receptor
        date: 2008-03-01
       words: 6263
      flesch: 62
     summary: Shen, F., Wu, M.D., Ratnam, M. et al. 1995. Sherry, A.D., Brown, R.D., Spiller, M. et al. 1989.
    keywords: cancer; cells; cho; dota; drug; et al; folate; gallium; peg; receptor; γ-2; γ-4
       cache: dti-1327.pdf
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        item: #32 of 101
          id: dti-1328
      author: Garrote, José A.; Gómez, Emma; León, Alberto J.; Bernardo, David; Calvo, Carmen; Fernández-Salazar, Luis; Blanco-Quirós, Alfredo; Arranz, Eduardo
       title: Cytokine, Chemokine and Immune Activation Pathway Profiles in Celiac Disease: An Immune System Activity Screening by Expression Macroarrays
        date: 2008-01-21
       words: 8137
      flesch: 65
     summary: References Azarnia, R., Reddy, S. et al. 1988. 13(9):1123–8. Valanciute, A., le Gouvello, S. et al. 2004.
    keywords: acd; cell; cytokine; disease; et al; expression; gene; gfd; gluten; group; infl; intestinal; ne e; p =; patients; r:0
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        item: #33 of 101
          id: dti-1329
      author: Tsen, Shaw-Wei D.
       title: Evidence of a Novel Gene from Aeromonas hydrophila Encoding a Putative Siderophore Receptor Involved in Bacterial Growth and Survival
        date: 2008-03-18
       words: 3131
      flesch: 48
     summary: Keywords: ferric iron, iron uptake, bacterial virulence, pathogenicity, infection Introduction Iron is necessary for many of the critical biochemical processes in bacterial growth and metabolism. Bacteria frequently possess feedback systems that upregulate or downregulate the expression of certain iron uptake proteins, including the energy transducing protein TonB, in response to environ- mental iron levels (Beddek et al. 2004).
    keywords: hydrophila; iron; nsr1; protein; receptor; siderophore
       cache: dti-1329.pdf
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        item: #34 of 101
          id: dti-1330
      author: Matsuyama, Masahide; Yoshimura, Rikio
       title: The Target of 5-Lipoxygenase is a Novel Strategy over Human Urological Tumors than the Target of Cyclooxygenase-2
        date: 2008-06-13
       words: 7956
      flesch: 56
     summary: BT cell line Similar to RCC cells, LOX inhibitors induced a reduction of cell viability with the half-maximal concentration of growth inhibition of BT cells in Table 1. PC cell line Similar to RCC and BT cells, LOX inhibitors induced a reduction of cell viability with the half-maximal concentration of growth inhibition of PC cells in the range of 10–80 μM. Although the effect of non- specifi c LOX inhibitor was strongest, the effect of 5-LOX inhibitor was stronger than that of 12-LOX inhibitor.
    keywords: cancer; cells; cox-2; expression; human; inhibitors; lox; lox inhibitor; patients; rcc; tissues; tumor
       cache: dti-1330.pdf
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        item: #35 of 101
          id: dti-1331
      author: Moretti, Rita; Torre, Paola; Vilotti, Cristina; Manganaro, Davide; Zanet, Luca; Antonello, Rodolfo M.
       title: Memantine: Reality and Potentiality
        date: 2008-05-08
       words: 7300
      flesch: 57
     summary: Tariot, P., Farlow, M., Grossberg, G. et al. 2003, May. Jones, R.W., Bayer, A., Inglis, F. et al. 2007, January.
    keywords: alzheimer; dementia; disease; dopamine; drug; effect; et al; glutamate; memantine; neurons; nmda; parkinson; patients; placebo; receptors
       cache: dti-1331.pdf
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        item: #36 of 101
          id: dti-1334
      author: Shen, Yuqiao; Senzer, Neil N.; Nemunaitis, John J.
       title: Use of Proteomics Analysis for Molecular Precision Approaches in Cancer Therapy
        date: 2008-04-23
       words: 9971
      flesch: 55
     summary: Using different fl uorescent dyes to label protein samples prior to gel electrophoresis, 2-D DIGE (two- dimensional differential in-gel electrophoresis) can, with reasonable sensitivity, process three protein samples on the same gel allowing for intragel relative quantifi cation. Using different fl uorescent dyes to label protein samples prior to gel electro- phoresis, the DIGE technique allows multiple samples to be co-separated and visualized on one 2-D gel (Unlu et al. 1997).
    keywords: 2002; 2005; 2007; analysis; cancer; cation; cell; data; electrophoresis; et al; gel; gene; identifi; labeling; mass; molecular; peptides; protein; proteomics; samples; technology
       cache: dti-1334.pdf
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        item: #37 of 101
          id: dti-1335
      author: Wilczak, Nadine; Keyser, Jacques De; Chesik, Daniel
       title: Targeting Insulin-Like Growth Factor-1 Signaling into the Central Nervous System for Promoting Myelin Repair
        date: 2008-04-18
       words: 6086
      flesch: 55
     summary: McMorris, F.A., Smith, T.M., DeSalvo, S. et al. 1986. Ogata, T., Iijima, S., Hoshikawa, S. et al. 2004.
    keywords: binding; brain; cns; et al; factor; growth; growth factor; igf-1; igfbps; insulin; oligodendrocytes
       cache: dti-1335.pdf
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        item: #38 of 101
          id: dti-1336
      author: Zangari, Maurizio; Elice, Francesca; Tricot, Guido; Fink, Louis
       title: Thrombophilia
        date: 2008-04-16
       words: 8396
      flesch: 48
     summary: Activated protein C resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism. Risk factors for pregnancy associated venous thromboembolism.
    keywords: antithrombin; apc; blood; cancer; ciency; defi; factor; leiden; mutation; patients; protein; protein c; resistance; risk; therapy; thrombophilia; thrombosis; vte
       cache: dti-1336.pdf
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        item: #39 of 101
          id: dti-1337
      author: Begleiter, Asher; El-Gabalawy, Nadia; Lange, Laurie; Leith, Marsha K.; Guziec, Lynn J.; Guziec Jr, Frank S.
       title: A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy
        date: 2009-01-15
       words: 6184
      flesch: 59
     summary: Human tumor cells have varied levels of NQO1 activity ranging from � 10 nmol. To test this hypothesis, we measured tumor cell growth inhibition produced by the series of BM analogs having different affi nities for activation by NQO1, in human tumor cell lines with a wide range of NQO1 activity.
    keywords: activity; agents; analogs; cancer; cells; growth; human; levels; mebm; nprbm; nqo1; pbm; tumor
       cache: dti-1337.pdf
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        item: #40 of 101
          id: dti-1346
      author: O’Blenes, Stacy B.; Li, Audrey W.; Bowen, Chris; DeBay, Drew; Althobaiti, Mohammed; Clarke, James
       title: Impact of Hepatocyte Growth Factor on Skeletal Myoblast Transplantation Late After Myocardial Infarction
        date: 2013-05-06
       words: 5163
      flesch: 55
     summary: We evaluated HGF delivery, SKMB engraftment, and expression of genes associated with post-MI remodeling. While it is possible that neonatal SKMBs used in their study behaved differently than the more clinically relevant adult SKMBs used in our model, it is also possible that the route of HGF delivery is important.
    keywords: animals; control; engraftment; hgf; myoblast; skmb; transplantation; ventricular; weeks
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        item: #41 of 101
          id: dti-1347
      author: Roth, Bodil; Manjer, Jonas; Ohlsson, Bodil
       title: Microscopic Colitis is Associated with Several Concomitant Diseases
        date: 2013-08-11
       words: 4007
      flesch: 56
     summary: Thus, MC patients have an increased prevalence of several diseases, not only of autoimmune origin. The aim of this study was to examine the prevalence of com- mon diseases in patients with MC and controls from the general population.
    keywords: age; colitis; controls; diseases; drug; patients; study; years
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        item: #42 of 101
          id: dti-1349
      author: Amin, Md. Lutful
       title: P-glycoprotein Inhibition for Optimal Drug Delivery
        date: 2013-08-19
       words: 4791
      flesch: 49
     summary: Keywords: P-glycoprotein, drug efflux, bioavailability, drug delivery, drug resistance, P-glycoprotein inhibitor http://dx.doi.org/10.4137/DTI.S12519 http://www.la-press.com http://www.la-press.com http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com mailto:lutful_amin@yahoo.com Amin 28 Drug Target Insights 2013:7 Introduction P-glycoprotein (P-gp) is one of the first members of the ATP-binding cassette (ABC) transporter which acts as a physiological barrier by extruding toxins and xeno- biotics out of cells.1,2 It is being extensively studied and experimented upon recently and is gaining much importance in numerous researches. Possible involvement of the drug transport- ers P glycoprotein and multidrug resistance-associated protein Mrp2 in dispo- sition of azithromycin.
    keywords: cancer; cells; delivery; drug; efflux; generation; glycoprotein; inhibition; inhibitors; multidrug; resistance; substrates; target
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        item: #43 of 101
          id: dti-1350
      author: Roth, Bodil; Manjer, Jonas; Ohlsson, Bodil
       title: Microscopic Colitis and Reproductive Factors Related to Exposure to Estrogens and Progesterone
        date: 2013-10-07
       words: 5528
      flesch: 58
     summary: Patients with lympho- cytic colitis had children less often compared to those with collagenous colitis (OR = 0.20, 95% CI = 0.05–0.86), however no differences were observed between patients with persistent or transient disease. The majority of MC patients had used OC at some period of their life.
    keywords: age; colitis; controls; factors; missing; patients; reference; study; value; years
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        item: #44 of 101
          id: dti-1352
      author: Gumuslu, Esen; Mutlu, Oguz; Sunnetci, Deniz; Ulak, Guner; Celikyurt, Ipek K.; Cine, Naci; Akar, Furuzan; Savlı, Hakan; Erden, Faruk
       title: The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice
        date: 2014-03-05
       words: 8383
      flesch: 57
     summary: The results of our study revealed that chronic agomelatine increased BDNF expression in the hippocampus, and our findings are consistent with those of recent studies.57,60 These findings provide new information regarding the molecular mechanisms that contribute to the chronic effects of the new antidepressant agomelatine on brain function. Quantitative RT-PCR revealed that CREB and BDNF gene expression levels were downregulated in UCMS-exposed mice, and these alterations were reversed by chronic agomelatine or melatonin treatment.
    keywords: agomelatine; animals; antidepressant; bdnf; chronic; control; creb; effects; expression; gene; group; latency; levels; melatonin; memory; mice; mwm; stress; test; treatment; trial
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        item: #45 of 101
          id: dti-1353
      author: Akar, Furuzan; Mutlu, Oguz; Celikyurt, Ipek K.; Bektas, Emine; Tanyeri, Mehmet H.; Ulak, Guner; Tanyeri, Pelin; Erden, Faruk
       title: Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
        date: 2014-04-29
       words: 5789
      flesch: 61
     summary: Rutten K, Prickaerts J, Hendrix M, van der Staay FJ, Sik A, Blokland A. Time- dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. For instance, the specific PDE5-Is sildenafil and vardenafil have been shown to improve object recognition memory when injected immediately fol- lowing the first trial.13 PDE5-Is are assumed to improve early processes of memory consolidation via either a presynaptic or postsynaptic mechanism.
    keywords: control; cued; effects; field; food; inhibitors; memory; mice; novel; object; rolipram; stfp; test; total; zaprinast
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        item: #46 of 101
          id: dti-1355
      author: Akimoto, Tetsu; Morishita, Yoshiyuki; Ito, Chiharu; Iimura, Osamu; Tsunematsu, Sadao; Watanabe, Yuko; Kusano, Eiji; Nagata, Daisuke
       title: Febuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease
        date: 2014-08-13
       words: 4360
      flesch: 59
     summary: Introduction Hyperuricemia, defined as a serum urate level exceeding the limit of solubility, mirrors supersaturation of the extracellu- lar fluid with urate, and predisposes affected subjects to gout, which is characterized by the tissue deposition of monosodium urate crystals, although it is a necessary but not a substantial factor for the development of the disease.1 The current urate- lowering strategies include reducing the urate production with xanthine oxidase (XO) inhibitors and accelerating the urinary excretion of uric acid (UA) with uricosuric agents.2,3 Uricosuric agents, such as probenecid and benzbromarone, may have lim- ited effectiveness in patients with reduced renal function.3,4 The purine analog XO inhibitor, allopurinol, has remained widely prescribed for the treatment of hyperuricemia, but requires dose adjustment in subjects with renal impairment, which may lead to a reduced benefit.2,3,5,6 Febuxostat, a nonpurine XO inhibitor that recently received marketing approval, has been focused on as an alternative option for the treatment of hyperuricemia in patients with chronic kidney disease (CKD) because it undergoes hepatic metabolism and may require less dose adjustment in asso- ciation with the renal function.6,7  Moreover, several lines of evidence have focused on the blockade of XO activity as a potential therapeutic strategy for various other kinds of oxida- tive stress-mediated tissue and vascular injuries.8,9  However, information regarding the experience with this therapeutic agent among patients with advanced CKD is limited.7 In this regard, the current study investigated the effects of febuxostat http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com http://www.la-press.com http://www.la-press.com/drug-target-insights-journal-j23 http://dx.doi.org/10.4137/DTI.S16524 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ mailto:tetsu-a@jichi.ac.jp Akimoto et al 40 Drug TargeT InsIghTs 2014:8 in patients with advanced CKD with hyperuricemia in terms of the reduction of the serum UA levels and the longitudinal changes in several serum indicators for oxidative stress. Materials and Methods Seventeen patients on chronic hemodialysis (HD) treatment who had serum UA levels above 8.0  mg/dL and who were not receiving anti-hyperuricemic agents participated in the study. The current observations suggest that even relatively low doses of febuxostat, which is approved at a dose of 40  to 60  mg/day as the standard dose for the treatment of hyperuricemia with or without gouty arthritis in Japan, may also work effectively among chronic HD patients for reducing the serum UA to a level that has been arbitrarily proposed as a therapeutic target for hyperuricemia.7,11,12 The validity of the indications for urate- lowering agents among overall subjects with asymptomatic After the treatment with oral febuxostat (month(s))
    keywords: chronic; disease; febuxostat; hyperuricemia; kidney; levels; patients; serum; stress; treatment
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        item: #47 of 101
          id: dti-1356
      author: Roth, Bodil; Berntorp, Kerstin; Ohlsson, Bodil
       title: The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus
        date: 2014-11-10
       words: 5557
      flesch: 50
     summary: As some of the patients with diabetes mellitus and gastrointestinal complaints had no pathological changes as found in the examinations (n  =  3), they were diagnosed as IBS patients. Thus, a subgroup of IBS patients may have enteric neu- ropathy, which remains undiscovered by non-sensitive, clini- cal examinations.
    keywords: antibodies; diabetes; dysmotility; expression; gastrointestinal; gnrh; hormone; ibs; igm; mellitus; patients; progonadoliberin-2; receptor
       cache: dti-1356.pdf
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        item: #48 of 101
          id: dti-1357
      author: Parvege, Md. Masud; Rahman, Monzilur; Hossain, Mohammad Shahnoor
       title: Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets
        date: 2014-12-09
       words: 8221
      flesch: 53
     summary: Target proteins found in the cytoplasm can be used as potential drug targets, whereas extracellular and membrane-bound proteins can work as probable vaccine targets.28 Mycoplasma hominis, drug targets, bioinformatics, genomics, proteomics CITATION:
    keywords: 50s; acids; analysis; cytoplasm; database; dna; drug; drug targets; drugbank; experimental; hominis; identification; list; membrane; metabolism; mycoplasma; novel; pathways; potential; proteins; res; ribosomal; study; targets
       cache: dti-1357.pdf
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        item: #49 of 101
          id: dti-1365
      author: Otegbade, Olayinka O; Ojo, Johnson A; Adefokun, Dolapo I; Abiodun, Oyindamola O; Thomas, Bolaji N; Ojurongbe, Olusola
       title: Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei–Infected Mice
        date: 2017-08-28
       words: 5437
      flesch: 57
     summary: It is worth noting that B sapida extract exhibited the most active antiplas- modial properties at the lowest dosage tested. The absence of death after administering 5000 mg/kg body weight of B sapida extract in the acute toxicity test suggests that the extract appears to be nontoxic, an observation supported by the toxicity scale principle, which states that any chemical showing an LD50 greater than 5000 mg/kg is practically non- toxic.30 In this report, the acute toxicity test conducted with the extracts demonstrate their safety because the highest dose caused no death.
    keywords: activity; berghei; coartem; day; dose; extract; group; malaria; mice; plant; prophylactic; sapida
       cache: dti-1365.pdf
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        item: #50 of 101
          id: dti-1366
      author: Friend Tambunan, Usman Sumo; Fardiansyah Nasution, Mochammad Arfin; Azhima, Fauziah; Parikesit, Arli Aditya; Toepak, Erwin Prasetya; Idrus, Syarifuddin; Kerami, Djati
       title: Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation
        date: 2017-04-20
       words: 8209
      flesch: 53
     summary: Molecular docking simulation of NS5 methyltransferase and modif ied SAH ligands The process of molecular docking simulation between enzyme and ligand begins by opening the previously optimized protein structure in .moe format and the ligand database in .mdb for- mat. Preparation of the standard ligands and the modif ied SAH ligands In this study, the modified SAH ligands and the standards were drawn in 2-dimensional format using ACD/Labs ChemSketch 12.01 software, which later can be saved in .mol
    keywords: asp146; binding; complex; dengue; docking; drug; dynamics; enzyme; interaction; ligands; m1356; m2696; methyltransferase; molecular; ns5; process; protein; sah; simulation; site; software; structure; virus
       cache: dti-1366.pdf
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        item: #51 of 101
          id: dti-1367
      author: Avasarala, Jagannadha
       title: Anti-CD20 Cell Therapies in Multiple Sclerosis—A Fixed Dosing Schedule for Ocrelizumab is Overkill
        date: 2017-11-08
       words: 2231
      flesch: 52
     summary: There is minimal scientific validity in infusing the drug every 6 months particularly if CD20 cell counts are negligible in the peripheral blood. Because OCR avidly targets CD20 cell populations and depletes them and as their numbers can be monitored by peripheral blood counts of CD19 cells, it remains poorly understood why OCR needs to be reinfused at sched- uled intervals regardless of CD20 cell counts.
    keywords: cd20; cell; counts; patients; rtx; treatment
       cache: dti-1367.pdf
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        item: #52 of 101
          id: dti-1371
      author: Bello, Edson José Monteiro; Correia, Amabel Fernandes; Marins, José Ricardo Pio; Merchan-Hamann, Edgar; Kanzaki, Luis Isamu Barros
       title: Predictors of Virologic Failure in HIV/AIDS Patients Treated with Highly Active Antiretroviral Therapy in Brasília, Brazil During 2002–2008
        date: 2011-11-24
       words: 5794
      flesch: 47
     summary: The viral load previous to HAART regimen initia- tion and T CD4+ cell count were evaluated as possible predictors of viral failure leading us to establish the cut off values to viral load . Anyway, disease prognosis in HIV infected subjects is more rigorously defined by the combination of plasmatic viral load quantification and T CD4+ cell count.1 It is internationally noted that the main predictive fac- tors for failure of antiretroviral therapy are T CD4+ cells low count and elevated viral load before com- mencing treatment.2
    keywords: antiretroviral; cd4; cell; copies; count; failure; haart; health; hiv; load; patients; therapy; treatment; viral
       cache: dti-1371.pdf
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        item: #53 of 101
          id: dti-1373
      author: Annabi, Borhane; Lord-Dufour, Simon; Vézina, Amélie; Béliveau, Richard
       title: Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent
        date: 2012-04-11
       words: 6082
      flesch: 51
     summary: (D) Total rnA isolation and qrT-Pcr were performed as described in the Methods section to assess MMP-9 gene expression in the above-described conditions. Results Sirt1 gene expression profiling in grade I-IV brain tumour tissues Fourthy-eight clinical tissue samples were first analyzed for Sirt1 gene expression profil using TissueScan™ cancer and normal tissue
    keywords: brain; cancer; cells; cox-2; endothelial; expression; fig; gapdh; gene; grade; hbmec; inhibition; iκb; mmp-9; pma; resveratrol; sirt1; target
       cache: dti-1373.pdf
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        item: #54 of 101
          id: dti-1374
      author: Pendleton, Hillevi; Alm, Ragnar; Fredrikson, Gunilla Nordin; Ohlsson, Bodil
       title: Antibodies Against Gonadotropin-Releasing Hormone in Patients with Posterior Laryngitis
        date: 2013-01-28
       words: 4507
      flesch: 55
     summary: Consecutive PL patients were included after examination. I o n Drug Target Insights 2013:7 1 Antibodies Against Gonadotropin-Releasing Hormone in patients with posterior Laryngitis Hillevi pendleton1, Ragnar Alm2, Gunilla nordin Fredrikson2,3 and Bodil ohlsson4 1Department of Clinical Sciences, Division of otorhinolaryngology, Skåne University Hospital, malmö, Lund University, Lund, Sweden. 2Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Skåne University Hospital, malmö, Lund University.
    keywords: acid; antibodies; controls; gnrh; gonadotropin; hormone; patients; posterior; reflux; study; symptoms
       cache: dti-1374.pdf
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        item: #55 of 101
          id: dti-1400
      author: Murakami, Takuya; Akimoto, Tetsu; Okada, Mari; Hishida, Erika; Sugase, Taro; Miki, Atsushi; Kohara, Marina; Yoshizawa, Hiromichi; Masuda, Takahiro; Kobayashi, Takahisa; Saito, Osamu; Muto, Shigeaki; Nagata, Daisuke
       title: Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia
        date: 2018-06-25
       words: 4224
      flesch: 49
     summary: The published literature lacks information on the safety of substitution with other antiviral agents; however, it has been proposed anecdotally that famciclo- vir may be a candidate for substitution—at least in patients who develop nephrotoxicity.37,38 However, famciclovir treatment may still be associated with some risk of neuropsychiatric events.39 Finally, we strongly recommend the accumulation of more cases similar to our own, thereby allowing us to clarify the nature of adverse valacyclovir-mediated reactions more precisely as well as establish an optimum management strategy, especially regarding appropriate valacyclovir dosing regimens in elderly patients with HZ who barely appear to have a favorable renal function. Valacyclovir or acyclovir neurotoxicity commonly develops in patients with an impaired renal function, implying a role of a declined renal clearance–mediated accumulation of acyclovir and/or its metabolites in the bloodstream.3,4 Given that the renal clearance of acyclovir absolutely exceeds that of creati- nine, indicating that renal tubular secretion is actively involved in the elimination of the agent,1 it is not surprising that acyclo- vir can induce renal failure through precipitation within the tubular lumen, which leads to obstructive nephropathy.2,8 In rare instances, interstitial nephritis and direct tubular necrosis from acyclovir may also result in renal insufficiency.2,3,8 Alternatively, or in addition, the GFR may decline due to an acyclovir-mediated increase in the total renal vascular resist- ance with a reduction in the renal plasma flow.2,11,27
    keywords: acyclovir; case; hyponatremia; levels; neurotoxicity; patient; renal; serum; sodium; treatment; valacyclovir
       cache: dti-1400.pdf
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        item: #56 of 101
          id: dti-1401
      author: Avasarala, Jagannadha
       title: DRESS Syndrome and Daclizumab Failure-Were Potentially Dangerous Signs Missed in Clinical Trials
        date: 2018-06-29
       words: 1753
      flesch: 47
     summary: This should serve as a cautionary tale for all clinicians who use “newer MS drugs” that have mushroomed in recent memory following a flurry of recent FDA approvals. Many stud- ies have reported DRESS syndrome patients with genetic predisposition linked to specific drugs and one wonders if Zinbryta use, DRESS syndrome, and HLA class II alleles were linked as well.
    keywords: dress; drug; patients; syndrome; zinbryta
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        item: #57 of 101
          id: dti-1406
      author: Mutlu, Oguz; Akar, Furuzan; Celikyurt, Ipek Komsuoglu; Tanyeri, Pelin; Ulak, Guner; Erden, Faruk
       title: 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice
        date: 2015-03-04
       words: 6438
      flesch: 68
     summary: Mutlu O, Ulak G, Belzung C. Effects of nitric oxide synthase inhibitors 1-(2 trifluoromethylphenyl)—imidazole (TRIM) and 7-nitroindazole (7-NI) on learning and memory in mice. Inhibition of nitric oxide synthase does not impair spatial learning.
    keywords: effects; latency; learning; maze; memory; mice; nitric; odq; oxide; test
       cache: dti-1406.pdf
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        item: #58 of 101
          id: dti-1407
      author: Zulkipli, Ihsan N.; David, Sheba R.; Rajabalaya, Rajan; Idris, Adi
       title: Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division
        date: 2015-06-15
       words: 6095
      flesch: 59
     summary: Among other properties, one favorable characteristic of an anticancer drug is its ability to block the uncontrollable process of cell division, as cancer cells are notorious for their abnormal cell division. Hence, many anticancer drugs target the microtu- bule skeleton in order to arrest cancer cells in mitosis, which eventually leads to cell death.
    keywords: anticancer; biol; cancer; cell; compounds; division; drug; dynamics; effects; insights; microtubule; mitosis; plants; potential; source; target; targeting; tubulin
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        item: #59 of 101
          id: dti-1408
      author: Ohlsson, Bodil; Melander, Olle
       title: Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection
        date: 2015-07-13
       words: 5818
      flesch: 54
     summary: Plasma peptide levels from all patients with inflammatory bowel disease and controls. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD).
    keywords: bowel; cohort; controls; copeptin; disease; fragment; ibd; levels; mpm; patients; peptide; plasma; precursor; study
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        item: #60 of 101
          id: dti-1410
      author: Imai, Toshimi; Akimoto, Tetsu; Ito, Chiharu; Masuda, Takahiro; Nagata, Daisuke
       title: Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
        date: 2015-11-11
       words: 2428
      flesch: 44
     summary: Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. 2009;32(4): 650–657. 2. Onoyama K, Kumagai H, Fujishima M. Hemodynamic and volume changes by ultrafiltration in refractory edema of diabetic nephrotic syndrome with severe renal insufficiency.
    keywords: dapagliflozin; day; diabetes; diuretic; glucose; nephrotic; sodium; syndrome; type
       cache: dti-1410.pdf
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        item: #61 of 101
          id: dti-1415
      author: Oblitas, Crhistian-Mario; Galeano-Valle, Francisco; La Cruz, Laura Vela-De; Toro-Cervera, Jorge Del; Demelo-Rodríguez, Pablo
       title: Omalizumab as a Provoking Factor for Venous Thromboembolism
        date: 2019-07-04
       words: 1710
      flesch: 49
     summary: Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review. Treatment with omalizumab was stopped.
    keywords: asthma; dimer; drug; omalizumab; risk; treatment; vte
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        item: #62 of 101
          id: dti-1416
      author: Orrico, Kathleen B
       title: Basic Concepts in Genetics and Pharmacogenomics for Pharmacists
        date: 2019-12-03
       words: 6273
      flesch: 49
     summary: To illustrate several of these concepts, let us examine how CYP2D6 gene variation relates to both the effectiveness and safety of the opioid analgesic drug codeine. Variant tables for the polymorphic CYP2C9, CYP2C19, and CYP2D6 genes are posted in the PharmVar database and include the corresponding phenotypic enzyme activity level.16 Clinically Actionable Pharmacogene Variation Generally, a gene-drug association is considered clinically actionable if information about genetic testing is included in the FDA-approved labeling.
    keywords: activity; alleles; base; cyp2d6; dna; drug; enzyme; gene; genome; human; pgx; protein; september; sequence; testing; variation
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        item: #63 of 101
          id: dti-1417
      author: Abdul Manap, Aimi Syamima; Vijayabalan, Shantini; Madhavan, Priya; Chia, Yoke Yin; Arya, Aditya; Wong, Eng Hwa; Rizwan, Farzana; Bindal, Umesh; Koshy, Shajan
       title: Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies
        date: 2019-07-31
       words: 16379
      flesch: 63
     summary: T H E M O D E L U S E D A N D S T U D Y D E S IG N D O S E O R F R E q U E N C Y E F F E C T O F B M E T R E A T M E N T R E F E R E N C E S In v iv o m o d e l E th y lc h o lin e a zi ri d in iu m i o n ( A F 6 4 A ) (2 n m o l/ 2 μ L )— IC V -i n d u c e d m a le W is ta r ra ts 2 0 , 4 0 , a n d 8 0 m g /k g B W B M E e n h a n c e d t h e e s c a p e l a te n c y ti m e ( P < .0 1) in t h e M o rr is w a te r m a ze t e st . D o u b le -b lin d , ra n d o m iz e d p la c e b o -c o n tr o lle d c lin ic a l tr ia l w it h a p la c e b o r u n -i n o f 6 w e e ks B a c o p a e x tr a c t, 3 0 0 m g d a ily , fo r 1 2 w e e ks E n h a n c e d A V LT d e la ye d w o rd r e c a ll m e m o ry s c o re s re la ti ve t o p la c e b o , s ig n ifi c a n t im p ro ve m e n t in s tr o o p re su lt s (P < .0 5 ) a n d a ls o d e c re a s e d in C E S D -1 0 d e p re s s io n s c o re s o ve r ti m e , a s w e ll a s d e c re a s e d in c o m b in e d s ta te p lu s tr a it a n x ie ty s c o re s a n d h e a rt a tt a c k .
    keywords: b o; c e; c o; c t; d b; d t; d u; e b; e d; e e; e m; e n; e s; e st; e t; e u; g e; h e; l e; m g; m o; n c; n d; n g; n h; n n; n s; n t; o n; o p; o u; p e; r e; s c; s o; s s; t h; t o; u n; w e; y e
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        item: #64 of 101
          id: dti-1418
      author: Kossaify, Antoine
       title: Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy
        date: 2019-07-03
       words: 5497
      flesch: 46
     summary: Incidence of thromboem- bolic complications within 30 days of electrical cardioversion performed within 48 hours of atrial fibrillation onset. de Riva-Silva M, Montero-Cabezas JM, Salgado-Aranda R, Lopez-Gil M, Fon- tenla-Cerezuela A, Arribas-Ynsaurriaga F. 1:1 atrial flutter after vernakalant administration for atrial fibrillation cardioversion.
    keywords: atrial; cardioversion; control; conversion; fibrillation; heart; management; onset; onset af; patients; rate; rhythm; sinus; vernakalant
       cache: dti-1418.pdf
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        item: #65 of 101
          id: dti-1419
      author: Hydery, Tasmina; Coppenrath, Valerie Azzopardi
       title: A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria
        date: 2019-06-21
       words: 6246
      flesch: 55
     summary: Therefore, if patients are treated in combination with other pegylated products, further monitoring for hypersensitivity reactions and anaphylaxis is recommended.11 Relevance to Patient Care and Clinical Practice The risk of adverse outcomes in PKU is related to disease sever- ity, blood phenylalanine concentration, and adherence to treat- ment.4 The assessment of blood phenylalanine concentrations may also be indicative of patient adherence to therapy.22 Poor adherence can manifest as failure to take medical foods or pre- scribed medications, and missing regular clinic appointments or blood phenylalanine testing.23 It is an oral PAH cofactor A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria Tasmina Hydery1 and Valerie Azzopardi Coppenrath2 1Department of Family Medicine and Community Health, UMass Medical School—Clinical Pharmacy Services (CPS), Shrewsbury, MA, USA. 2School of Pharmacy—Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences (MCPHS) University, Worcester, MA, USA. ABSTRACT OBjECTivE: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a phenylalanine-metabolizing enzyme indicated to reduce blood phenylalanine concentrations, pegvaliase injection.
    keywords: blood; concentrations; dose; group; patients; pegvaliase; phase; phenylalanine; phenylketonuria; pku; study; therapy; treatment; µmol
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        item: #66 of 101
          id: dti-1420
      author: Fragkou, Paraskevi; Souli, Maria; Theochari, Maria; Kontopoulou, Christina; Loukides, Stelios; Koumarianou, Anna
       title: A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab
        date: 2016-05-22
       words: 2765
      flesch: 44
     summary: Nakashima K, Naito T, Omori S, et al. Organizing pneumonia induced by nivolumab in a patient with metastatic melanoma. Introduction New monoclonal antibodies (Mabs) targeting the immune checkpoint blockade have revolutionized the treatment of advanced melanoma patients.
    keywords: athens; immune; melanoma; patient; pd-1; pembrolizumab; pneumonia; university
       cache: dti-1420.pdf
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        item: #67 of 101
          id: dti-1422
      author: Ueda, Yuichiro; Ishii, Hiroki; Kitano, Taisuke; Shindo, Mitsutoshi; Miyazawa, Haruhisa; Ito, Kiyonori; Hirai, Keiji; Kaku, Yoshio; Mori, Honami; Hoshino, Taro; Ookawara, Susumu; Kakei, Masafumi; Tabei, Kaoru; Morishita, Yoshiyuki
       title: Effects and Safety of Linagliptin as an Add-on Therapy in Advanced-Stage Diabetic Nephropathy Patients Taking Renin–Angiotensin–Aldosterone System Blockers
        date: 2016-09-11
       words: 3686
      flesch: 53
     summary: block- ers are used as first-line agents for blood pressure control in DMN patients. They have been reported to decrease blood pressure and have beneficial nephroprotective and cardiopro- tective effects.10–12 For blood glucose control, although many kinds of hypoglycemic agents have been developed, most cannot be used in DMN patients with decreased renal function because they have diminished elimination by the kidneys, and may cause unfavorable side effects.
    keywords: blockers; diabetes; dmn; effects; glucose; linagliptin; metabolism; patients; stage; study
       cache: dti-1422.pdf
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        item: #68 of 101
          id: dti-1423
      author: Kitanaka, Junichi; Kitanaka, Nobue; Hall, F. Scott; Uhl, George R.; Takemura, Motohiko
       title: Brain Histamine N-Methyltransferase as a Possible Target of Treatment for Methamphetamine Overdose
        date: 2016-03-02
       words: 5984
      flesch: 47
     summary: http://www.la-press.com http://www.la-press.com/drug-target-insights-journal-j23 Kitanaka et al 4 Drug TargeT InsIghTs 2016:10 dependently decreased METH-induced stereotypical biting, while increasing sniffing, suggesting that metoprine may ame- liorate high-dose METH-induced symptoms by producing a leftward shift in METH behavioral effects (Table 1).65 In brain, for termination of histaminergic neurotransmission after activa- tion of histamine receptors, histamine is transferred from the extracellular space into cytoplasm by organic cation transporter 3 and/or the equilibrative nucleoside transporter (ENT4), and catabolized by the cytosolic enzyme histamine N-methyltrans- ferase (HMT) to form N-methylhistamine, which is inactive in the histaminergic system.55,56 HMT is the sole enzyme that degrades histamine in brain,57,58 whereas diamine oxidase (DAO; histaminase) catabolizes histamine in peripheral tis- sues.49,59
    keywords: abuse; activity; behavioral; brain; drug; effects; histamine; hmt; kitanaka; levels; meth; methamphetamine; metoprine; mice; overdose; pharmacol; receptors; stereotypical; stereotypy; treatment
       cache: dti-1423.pdf
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        item: #69 of 101
          id: dti-1424
      author:  ,  
       title: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis
        date: 2016-01-03
       words: 3333
      flesch: 36
     summary: Structural proteomic studies on ITA tissue showed differential expression of proteins that are implicated in cytoskeleton activity regulation,21 in the migrative capacity of vascular smooth muscle cells, extracellular matrix composition, coagulation, apoptosis, and heat shock response.22 Interestingly, a proteomic analysis of the secrete of ITA, known as secretome, demonstrated an increased production of gelsolin, vinculin, lamin A/C and phosphoglucomutase 5 by mammary arterial tissues. Differential profiles of protein expression exclusively present in ITA tissues and secrete, but not in the other vessels, have been intriguingly discovered (Fig. 1) and the identification of these proteins would provide in the future precious information to elucidate reasons of ITA superiority in CABG.
    keywords: cardiovascular; devices; drug; insights; ita; spadaccio; surgery; target; tissue; university
       cache: dti-1424.pdf
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        item: #70 of 101
          id: dti-1425
      author: Rapetto, Filippo; Bruno, Vito D.; Guida, Gustavo; Marsico, Roberto; Chivasso, Pierpaolo; Zebele, Carlo
       title: Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery
        date: 2016-05-29
       words: 4343
      flesch: 50
     summary: A BSTR ACT: Sternal wound infections represent one of the most frequent complications after cardiac surgery and are associated with high postoperative mortality. Although several retrospective analyses and randomized controlled trials have studied the use of GICSs in cardiac surgery, conclusions regarding their efficacy in preventing sternal wound infection are inconsistent.
    keywords: cardiac; collagen; dswi; gentamicin; gics; infection; patients; risk; sternal; surgery; use; wound
       cache: dti-1425.pdf
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        item: #71 of 101
          id: dti-1548
      author: Mabrouk, Nada M.K.; Elkaffash, Dalal M.; Abdel-Hadi, Mona; Abdelmoneim, Salah-ElDin; Saad ElDeen, Sameh; Gewaifel, Gihan; Elella, Khaled A.; Osman, Maher; Baddour, Nahed
       title: Identification of the possible therapeutic targets in the insulin-like growth factor 1 receptor pathway in a cohort of Egyptian hepatocellular carcinoma complicating chronic hepatitis C type 4
        date: 2020-04-08
       words: 8463
      flesch: 58
     summary: and downregulated genes with identification of most frequently coregulated genes, followed by correlation of gene expression with different patient/tumor characteristics. Keywords: Gene expression, Hepatitis C virus, Hepatocellular carcinoma, Molecular therapeutic targets Received: January 8, 2020 Accepted: January 20, 2020 Published online: April 8, 2020 Corresponding author: Nada M.K. Mabrouk Department of Pathology University of Alexandria Alexandria, Egypt nada_mabrouk@hotmail.com, nada.mabrouk@alexmed.edu.eg Introduction Hepatocellular carcinoma (HCC) has become the fifth most common cancer in men worldwide and the ninth in women and the third leading cause of cancer-related deaths.
    keywords: alexandria; analysis; cancer; carcinoma; cases; cells; expression; genes; hcc; hccs; hcv; hepatocellular; human; liver; molecular; pathway; present; related; study; tumor
       cache: dti-1548.pdf
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        item: #72 of 101
          id: dti-2024
      author: de Souza, Elen M.; Oliveira, Gabriel M.; de Nazaré C. Soeiro, Maria
       title: Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
        date: 2007-12-31
       words: 4987
      flesch: 57
     summary: Lo Presti, M.S., Rivarola, H.W. and Bustamante, J.M. et al. 2004. Lansiaux, A.F., Tanious, Z. and Mishal, L. et al. 2002.
    keywords: cardiac; chagas; cruzi; db569; disease; dpi; et al; infection; mice; souza
       cache: dti-2024.pdf
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        item: #73 of 101
          id: dti-2025
      author: Kusumanto, Yoka H.; Meijer, Coby; Dam, Wendy; Mulder, Nanno H.; Hospers, Geke A.P.
       title: Circulating Vascular Endothelial Growth Factor (VEGF) Levels in Advanced Stage Cancer Patients Compared to Normal Controls and Diabetes Mellitus Patients with Critical Ischemia
        date: 2007-12-31
       words: 4006
      flesch: 53
     summary: Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic reti- nopathy or proliferative vitreoretinopathy. Gasparini, G., Toi, M., Gion, M. et al. 1997.
    keywords: cancer; elevated; et al; factor; growth; levels; patients; tumor; vascular; vegf
       cache: dti-2025.pdf
  plain text: dti-2025.txt

        item: #74 of 101
          id: dti-2103
      author: Sharma, Monica; Sharma, Swati; Ray, Pallab; Chakraborti, Anuradha
       title: Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor
        date: 2020-10-07
       words: 5278
      flesch: 53
     summary: S. pneumoniae adherence to host cells decreased significantly with UDP treatments. Inhibitor toxicity to host cells A549 cell monolayers were treated with different concen- trations of UDP for 1 hour at 37°C and untreated cells were taken as reference.
    keywords: a549; cells; effect; fig; host; inhibitor; pneumoniae; streptococcus; udp; ugpase
       cache: dti-2103.pdf
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        item: #75 of 101
          id: dti-2170
      author: Abayneh, Mengistu; Worku, Teshale
       title: Prevalence of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacilli: A meta-analysis report in Ethiopia
        date: 2020-10-05
       words: 7564
      flesch: 60
     summary: For instance, in Ethiopia studies show that about 36.8% of the population got antibiotics from community drug retail outlets without a prescription and 67.9% of people had dis- continued the use of antibiotics once their symptoms subside (3). Many reports have documented the differ- ence in ESBL proportion estimates between hospitals versus community-based surveys (23,25,27,30).
    keywords: analysis; articles; beta; crossref; esbl; estimates; ethiopia; gnb; isolates; mdr; meta; resistance; spectrum; studies; study
       cache: dti-2170.pdf
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        item: #76 of 101
          id: dti-2185
      author: Tsuchiya, Hironori; Mizogami, Maki
       title: Interaction of drugs with lipid raft membrane domains as a possible target
        date: 2020-12-22
       words: 11494
      flesch: 44
     summary: Published by AboutScience TABLE IV - Interaction of anticancer drugs with lipid raft membrane domains and membranes Drug class Drug Membrane Induced membrane modification Reference Alkylphospholipid Edelfosine (≥20 mol%) MLVs (POPC, SM and cholesterol, 1:1:1, molar ratio) Human acute T-cell leukemia cells Increased the fluidity of lipid rafts Colocalized in membrane lipid rafts 69 Alkylphospholipid Perifosine (100 μM) ODPC (100 μM) GUVs (DOPC, SM and cholesterol, 1:1:1 molar ratio) Disrupted membrane raft domains 70 Alkylphospholipid Edelfosine (5-10 mol%) Miltefosine (5-10 mol%) MLVs or ULVs (POPC, N-palmitoyl-SM and cholesterol, 1:1:1 molar ratio) Increased the fluidity of raft model membranes 71 Alkylphospholipid Erucylphosphocholine (≥0.3 mol%) Raft-mimic Langmuir monolayers (SM and cholesterol, 2:1 molar ratio) Increased the membrane raft fluidity and weakened the interaction between cholesterol and SM 72 Phar- macologically relevant receptors, ion channels and enzymes are localized or cluster in membrane lipid rafts and caveolae (8-11).
    keywords: cancer; cells; cholesterol; crossref medline; domains; dopc; drug; effects; fluidity; interaction; lipid; lipid rafts; medline; membrane; membrane fluidity; membrane lipid; model; mol%; molar; phase; popc; raft; ratio; receptors
       cache: dti-2185.pdf
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        item: #77 of 101
          id: dti-2188
      author: Ayed, Khadija; Hadi Khalifa, Islam Latifa; Mokaddem, Salma; Ben Khamsa Jameleddine, Saloua
       title: Paradoxical bronchoconstriction caused by β2-adrenoceptor agonists
        date: 2020-10-05
       words: 2534
      flesch: 54
     summary: After salbutamol Measured % Predicted Measured % The aim of this study is to report a case of paradoxical bronchoconstriction caused by β 2 adrenergic agonists.
    keywords: agonists; bronchoconstriction; fev; fvc; paradoxical; spirometry; terbutaline
       cache: dti-2188.pdf
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        item: #78 of 101
          id: dti-2192
      author: de A. Morais, Ana H.; de Medeiros, Amanda F.; Medeiros, Isaiane; de Lima, Vanessa C.O.; Luz, Anna B.S.; Maciel, Bruna L.L.; Passos, Thais S.
       title: Tamarind (Tamarindus indica L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity
        date: 2021-04-01
       words: 7535
      flesch: 51
     summary: For this, Carvalho et al (62) used Wistar rats with diet-induced obesity, assessing food consumption and other biochemical parameters, using the 25 mg/kg dose of TTI, as proposed by Ribeiro et al (61). Xu et al (41) investigated the possible routes of SARS-CoV-2 infection in the oral cavity mucosa, exploring the expression of ACE-2 and the proportion and composition of the cells responsible for this function based on RNA-seq profiles and cell transcript-independent data.
    keywords: adipose; coronavirus; cov-2; covid-19; crossref; effects; et al; food; infection; inflammation; inhibitor; leptin; obesity; potential; protease; protein; pubmed; risk; sars; tissue; trypsin; tti
       cache: dti-2192.pdf
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        item: #79 of 101
          id: dti-2197
      author: Khamsai, Sittichai; Sawanyawisuth, Kittisak; Senthong, Vichai; Limpawattana, Panita; Chindaprasirt, Jarin; Intapan, Pewpan M; Maleewong, Wanchai; Tiamkao, Somsak; Chotmongkol, Verajit; Ngamjarus, Chetta
       title: Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review
        date: 2021-03-08
       words: 478
      flesch: 51
     summary: Search strategy in Central on 22 November 2019 (3 articles) #1 meningit*:ti,ab,kw #2 eosinophil*:ti,ab,kw #3 parasites #4 (parasitic diseases) OR helminthiasis OR (nematode infections) #5 parasit* OR helminth* OR nematod* #6 Angiostrongylus cantonensis #7 (angiostrongylus cantonensis) #5 Search (parasit* OR helminth* OR nematod*) #6 Search Angiostrongylus cantonensis #7 Search ((angiostrongylus cantonensis) OR (A. cantonenesis)) #8 Search (angiostrongylus cantonensis) OR (a. cantonensis) #9 Search (#3 OR #4 OR #5 OR #6 OR #7 OR #8) #10 Search (#1 AND #2) #11 Search (#9 AND #10) #12 Search Randomized Controlled Trial [Publication Type] #13 Search (random* OR placebo* OR trial* OR groups OR (controlled study))
    keywords: search
       cache: dti-2197.pdf
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        item: #80 of 101
          id: dti-2277
      author: Watashi, Koichi; Shimotohno, Kunitada
       title: Cyclophilin and Viruses: Cyclophilin as a Cofactor for Viral Infection and Possible Anti-Viral Target
        date: 2007-01-01
       words: 7213
      flesch: 63
     summary: Zander, K., Sherman, M.P., Tessmer, U., Bruns, K., Wray, V., Prechtel, A. T., Schubert, E., Henklein, P., Luban, J. and Neidleman, J. et al. 2003. From the results, the hypothesis was proposed by Luban et al. that CA binding by CyPA prevented normal anti- viral effects mediated by TRIM5α during HIV-1 infection of human cells, but this same interaction mediated HIV-1 restriction in nonhuman primate cells (Sokolskaja et al. 2006; Luban, in press).
    keywords: 2005; activity; binding; cells; csa; cyclophilin; cypa; cypb; et al; genome; hcv; human; protein; replication; rna; virus
       cache: dti-2277.pdf
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        item: #81 of 101
          id: dti-2291
      author: Tongdee, Sukanya; Sawunyavisuth, Bundit; Sukeepaisarnjaroen, Wattana; Boonsawat, Watchara; Khamsai, Sittichai; Sawanyawisuth, Kittisak
       title: Clinical factors predictive of appropriate treatment in COPD: a community hospital setting
        date: 2021-11-13
       words: 3348
      flesch: 57
     summary: Full information is available at www.aboutscience.eu Clinical factors predictive of appropriate treatment in COPD: a community hospital setting Sukanya Tongdee1, Bundit Sawunyavisuth2, Wattana Sukeepaisarnjaroen3, Watchara Boonsawat3, Sittichai Khamsai3, Kittisak Sawanyawisuth3 1Department of Medicine, Chumpae Hospital, Khon Kaen - Thailand 2Department of Marketing, Faculty of Business Administration and Accountancy, Khon Kaen University, Khon Kaen - Thailand 3Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand ABSTRACT Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. However, there are limited data on predictors of appropriate treatment in patients with COPD.
    keywords: copd; crossref; factors; gold; guideline; patients; pubmed; study; treatment
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        item: #82 of 101
          id: dti-2342
      author: Losi, Serena; Berra, Cesare Celeste Federico; Fornengo, Riccardo ; Pitocco, Dario ; Biricolti, Giovanni ; Orsini Federici, Marco 
       title: The role of patient preferences in adherence to treatment in chronic disease: a narrative review
        date: 2021-11-08
       words: 6533
      flesch: 48
     summary: Full information is available at www.aboutscience.eu The role of patient preferences in adherence to treatment in chronic disease: a narrative review Serena Losi1, Cesare Celeste Federico Berra2, Riccardo Fornengo3, Dario Pitocco4, Giovanni Biricolti5, Marco Orsini Federici1 1Eli Lilly Italy S.p.A., Sesto Fiorentino - Italy 2IRCCS MultiMedica, Sesto San Giovanni, Milano - Italy 3S.S.D. di Diabetologia ASL TO4, Torino - Italy 4Diabetes Care Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma - Italy 5Eli Lilly Italy S.p.A., Roma - Italy ABSTRACT Adherence to prescribed medication is important to the management of all diseases, especially those of chronic nature. We reviewed the available evidences on the impact of patient preferences for therapy on adherence to a prescribed treatment in chronic diseases requiring long-term treatment.
    keywords: adherence; chronic; crossref; diabetes; osteoporosis; patient; persistence; preference; pubmed; satisfaction; studies; study; therapy; treatment
       cache: dti-2342.pdf
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        item: #83 of 101
          id: dti-2343
      author: Zuccarini, Silvio ; Puce, Fabrizio ; Crisà, Alessandro 
       title: Anatomical and functional responses to single brolucizumab injection in neovascular age-related macular degeneration patients not responding to antiangiogenics: a case series
        date: 2022-03-24
       words: 4238
      flesch: 48
     summary: Refractory neovascular age-related macular degeneration: time-dependent changes of central retinal thickness with anti-VEGF treatment. Optimizing anti-VEGF treatment outcomes for patients with neovascular age-related macular degeneration.
    keywords: age; anti; brolucizumab; crossref; degeneration; fluid; injection; patients; pubmed; treatment
       cache: dti-2343.pdf
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        item: #84 of 101
          id: dti-2347
      author: Zambelli, Vanessa; Rizzi, Laura; Delvecchio, Paolo; Bresciani, Elena; Rezoagli, Emanuele ; Molteni, Laura; Meanti, Ramona; Cuttin, Maria Serena; Bovo, Giorgio; Coco, Silvia; Omeljaniuk , Robert  J.; Locatelli, Vittorio; Bellani, Giacomo; Torsello, Antonio
       title: Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury
        date: 2021-11-21
       words: 5889
      flesch: 53
     summary: In an extended study, mice were observed for a subsequent 14 days in order to assess lung fibrosis. The results of the pres- ent research demonstrate that hexarelin treatment reduces the development of lung fibrosis and further suggests that specific synthetic GHS could be developed in order to modu- late lung and cardiac fibrosis such as those associated with COVID-19 infections.
    keywords: acid; anova; ards; crossref; fibrosis; hcl; hexarelin; instillation; lung; mice; p<0.01; post; treatment; vehicle
       cache: dti-2347.pdf
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        item: #85 of 101
          id: dti-2355
      author: Carriero, Martino
       title: Erythrodermic psoriasis and palmoplantar hyperkeratosis successfully treated with secukinumab: a case report
        date: 2022-03-07
       words: 3310
      flesch: 48
     summary: A review of secukinumab in psoriasis treatment. Psoriasis may occur in different forms, such as plaque pso- riasis (characterized by dry scaly patches), which represents 80%-90% of psoriasis cases; pustular psoriasis (contains pus- like fluid mainly infiltrated with white blood cells); erythro- dermic psoriasis (EP, characterized by exfoliation of fine scaly skin with pain and itching); guttate psoriasis (characterized by drop-like dots); and inverse psoriasis (affects the flexure surfaces and characterized by smooth inflamed lesions) (1).
    keywords: crossref; erythrodermic; il-17a; patients; psoriasis; pubmed; secukinumab; treatment
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        item: #86 of 101
          id: dti-2403
      author: Hammar, Oskar; Veress, Bela; Montgomery, Agneta; Ohlsson, Bodil 
       title: Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility
        date: 2012-12-31
       words: 3499
      flesch: 49
     summary: Thus, continuous stimulation by leu- prolide exerts antagonistic GnRH effects, leading to absence of LH secretion and stimulation.9,10 The pres- ent finding of LH receptors on enteric neurons gives a morphological explanation to this hypothesis, and absence of LH stimulation on the neural receptors could explain the reduction of symptoms.11 At the same time as continuous stimulation of leu- prolide acetate improves patients with gastrointestinal complaints,7,8 repeated intermittent treatment with the analog buserelin in the setting of repeated in vitro fertilization (IVF) has been linked to the development of CIPO in one patient.17 Gonadotropin- releasing hormone and its receptor have been found on enteric neurons,17,27 why the effect evoked by GnRH analogs may be direct on enteric neurons as well, in addition to an effect on the hypothalamic-pituitary- gonadal axis. However, presence of LH receptors in the gastrointestinal tract has never been described.
    keywords: bowel; cells; dysmotility; gastrointestinal; group; hormone; patients; range; receptor; tract
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        item: #87 of 101
          id: dti-2422
      author: Phungoen, Pariwat; Sarunyaparit, Jessada; Apiratwarakul, Korakot; Wonglakorn, Lumyai; Meesing, Atibordee; Sawanyawisuth, Kittisak
       title: The association of ESBL Escherichia coli with mortality in patients with Escherichia coli bacteremia at the emergency department
        date: 2022-10-17
       words: 4355
      flesch: 58
     summary: Discussion The prevalence of ESBL E. coli bacteremia at the ED in this study was 3.29%, which is lower than previously reported in community settings (6.7%-9.5%) (10,11,16). Methods: This was a retrospective cohort study conducted at the Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University in Thailand aimed at evaluating the possible association between ESBL E. coli bacteremia and mortality in the ED.
    keywords: bacteremia; coli; crossref; esbl; factors; lactate; mortality; patients; serum; study
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        item: #88 of 101
          id: dti-2476
      author: Sen, Pooja; Vijay, Mukund; Singh, Shweta; Hameed, Saif; Vijayaraghvan, Pooja
       title: Understanding the environmental drivers of clinical azole resistance in Aspergillus species
        date: 2022-11-22
       words: 9176
      flesch: 50
     summary: Aspergillus spe- cies and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance. Escribano P, Recio S, Peláez T, Bouza E, Guinea J. Aspergillus fumigatus strains with mutations in the cyp51A gene do not https://doi.org/10.1371/journal.pone.0114745 https://www.ncbi.nlm.nih.gov/pubmed/25478929 https://doi.org/10.1007/s10096-017-2919-6 https://www.ncbi.nlm.nih.gov/pubmed/28161741 https://doi.org/10.1007/s10096-017-2921-z https://www.ncbi.nlm.nih.gov/pubmed/28161744 https://doi.org/10.1111/myc.12393 https://www.ncbi.nlm.nih.gov/pubmed/26449506 https://doi.org/10.1086/376525 https://www.ncbi.nlm.nih.gov/pubmed/12975753 https://doi.org/10.1053/rmed.2001.1047 https://www.ncbi.nlm.nih.gov/pubmed/11392574 https://doi.org/10.2165/11596540-000000000-00000 https://www.ncbi.nlm.nih.gov/pubmed/22141384 https://doi.org/10.1017/S0021859605004971 https://doi.org/10.1016/S0190-9622(08)81495-8 https://www.ncbi.nlm.nih.gov/pubmed/8176006 https://doi.org/10.1021/jm00194a023 https://www.ncbi.nlm.nih.gov/pubmed/490531 https://doi.org/10.1086/367933 https://www.ncbi.nlm.nih.gov/pubmed/12594645 https://doi.org/10.1111/j.1470-9465.2004.00841.x https://www.ncbi.nlm.nih.gov/pubmed/14748798 https://doi.org/10.2165/00003495-200767020-00009 https://www.ncbi.nlm.nih.gov/pubmed/17284090 https://doi.org/10.1111/j.1368-5031.2004.0099.x https://www.ncbi.nlm.nih.gov/pubmed/14994974 https://www.ncbi.nlm.nih.gov/pubmed/20112166 https://doi.org/10.1586/14787210.2015.1032939 https://www.ncbi.nlm.nih.gov/pubmed/25843556 https://doi.org/10.1128/AAC.01599-09 https://www.ncbi.nlm.nih.gov/pubmed/20385860 https://doi.org/10.1128/AAC.40.2.279 https://www.ncbi.nlm.nih.gov/pubmed/8834867 https://doi.org/10.1128/CMR.11.2.382 https://www.ncbi.nlm.nih.gov/pubmed/9564569 https://doi.org/10.1016/S1367-5931(97)80007-5 https://www.ncbi.nlm.nih.gov/pubmed/9667858 https://doi.org/10.2165/00003495-200767110-00004 https://www.ncbi.nlm.nih.gov/pubmed/17661528 https://doi.org/10.1086/525258 https://www.ncbi.nlm.nih.gov/pubmed/18177225 https://doi.org/10.1111/j.1469-0691.2009.02911.x https://www.ncbi.nlm.nih.gov/pubmed/19673966 https://doi.org/10.1179/joc.2011.23.6.319 https://www.ncbi.nlm.nih.gov/pubmed/22233814 https://doi.org/10.1021/acs.jafc.5b02728 https://www.ncbi.nlm.nih.gov/pubmed/26289797 https://www.apsnet.org/edcenter/apsnetfeatures/Pages/Fungicides.aspx https://doi.org/10.1002/ps.4029 https://www.ncbi.nlm.nih.gov/pubmed/25914201 https://doi.org/10.1080/03601230009373291 https://www.ncbi.nlm.nih.gov/pubmed/10968606 https://doi.org/10.1128/JCM.44.5.1782-1787.2006 https://www.ncbi.nlm.nih.gov/pubmed/16672407 https://doi.org/10.1128/AAC.47.10.3085-3088.2003 https://www.ncbi.nlm.nih.gov/pubmed/14506013 https://doi.org/10.1016/j.medmal.2013.02.010 https://www.ncbi.nlm.nih.gov/pubmed/23562488 https://doi.org/10.1128/AAC.48.7.2747-2750.2004 https://www.ncbi.nlm.nih.gov/pubmed/15215142 https://doi.org/10.1128/AAC.01092-06 https://www.ncbi.nlm.nih.gov/pubmed/17371828 https://doi.org/10.1093/jac/dkq450 https://www.ncbi.nlm.nih.gov/pubmed/21131690 https://doi.org/10.1128/JCM.00213-11 https://www.ncbi.nlm.nih.gov/pubmed/21508152 Environmental drivers of Aspergillus azole resistance34 © 2022
    keywords: agents; antifungal; antimicrob; aspergillosis; aspergillus; aspergillus fumigatus; azole; azole resistance; chemother; clinical; crossref; cyp51a; drug; fumigatus; india; infect; infections; isolates; l98h; mutations; patients; pubmed; resistance; species; study
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        item: #89 of 101
          id: dti-2477
      author: Zainol Abidin, Ismin; Murphy, Emma; Fehrenbach, Gustavo Waltzer; Rezoagli, Emanuele; Gately, Noel; Major, Ian
       title: A systematic review of mucoadhesive vaginal tablet testing
        date: 2023-01-16
       words: 16928
      flesch: 48
     summary: This review aims to assemble and discuss the key param- eters and unique methodologies that should be considered when evaluating vaginal tablet formulations. Inter-batch com- parison studies involved vaginal tablet formulations that were prepared in different batches varying in different types and/or ratios, and/or combinations of mucoadhesive polymers in each batch.
    keywords: abidin et; al drug; articles; batches; cevher et; chitosan; comparison; crossref; delivery; dissolution; drug; et al; formulation; khan et; mucoadhesive; pendekal et; perioli et; polymer; pubmed; pérez et; release; research; study; swelling; tablet; vaginal; √ √
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        item: #90 of 101
          id: dti-2481
      author:  Shah, Syed Fahim; Paracha, Sohail Aziz; Ullah, Waheed;  Muhammad, Iqbal; Iqbal, Somaid; Gul, Aisha; Hussain, Mudassir; Ullah, Hafiz; Zaman, Sadir
       title: Success of 14-day triple and quadruple therapy for the control of Helicobacter pylori infections in Kohat district
        date: 2022-12-19
       words: 3752
      flesch: 58
     summary: Published by AboutScience - www.aboutscience.eu TABLE II - Gastrointestinal symptom of patients Symptom Numbers Percentage (%) Epigastric pain 153/178 85.95 Recurrent abdominal pain 138/178 77.52 Nausea 141/178 79.21 Vomiting 70/178 39.32 Ballottement 30/178 16.85 Water brush 65/178 36.51 The hematological parameters of H. pylori patients included (n = 52) H. pylori positive patients whose hemato- logical values were compared with H. pylori negative control group (n = 52). The relationship between hematological para- meters of H. pylori positive patients and H. pylori negative control group was evaluated using confidential interval method by which the values are calculated for each para- meter that will fall between intervals.
    keywords: crossref; eradication; helicobacter; infection; patients; pylori; study; therapy; treatment
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        item: #91 of 101
          id: dti-2482
      author: Pandey, Ramendra Pati; Mukherjee, Riya; Chang, Chung-Ming
       title: Antimicrobial resistance surveillance system mapping in different countries
        date: 2022-11-30
       words: 8878
      flesch: 40
     summary: It is the national human medicine AMR surveillance system. Similarly, AMR surveillance system for humans is also ana- lyzed by different organizations formed in these six European countries.
    keywords: amr; amr surveillance; animals; antibiotic; antimicrobial; approach; bacteria; countries; data; drug; european; food; health; human; monitoring; national; research; resistance; species; surveillance; surveillance system; system
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        item: #92 of 101
          id: dti-2510
      author: Shetty, Bhavya; Fazal, Ibrahim; Khan, Safiya Fatima; Nambiar, Manjusha; Irfana D, Khadijathul; Prasad, Rohit; Raj, Akshata
       title: Association between cardiovascular diseases and periodontal disease: more than what meets the eye
        date: 2023-02-02
       words: 6510
      flesch: 48
     summary: Full information is available at www.aboutscience.eu Association between cardiovascular diseases and periodontal disease: more than what meets the eye Bhavya Shetty1, Ibrahim Fazal1, Safiya Fatima Khan2, Manjusha Nambiar2, Khadijathul Irfana D1, Rohit Prasad1, Akshata Raj1 1Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India 2Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India ABSTRACT Cardiovascular diseases (CVDs) are inflammatory diseases of coronary arteries accompanying atheroma forma- tion that can spawn impairment and, in severe cases, death. In recent decades, investigators have focused their impact on CVD by periodontal disease (PD).
    keywords: association; atherosclerosis; clin; crossref; cvd; disease; et al; evidence; health; heart; pathogens; patients; periodontal; periodontitis; review; risk; studies; study; therapy
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        item: #93 of 101
          id: dti-2522
      author: Sim, Yi Xing; Lee, Qiao Wei; Abushelaibi, Aisha; Lai, Kok-Song; Lim, Swee Hua Erin; Maran, Sathiya
       title: Current molecular approach for diagnosis of MRSA: a meta-narrative review
        date: 2022-12-31
       words: 7435
      flesch: 51
     summary: All the studies reviewed and appraised in this synthesis are summarized in Table I. TABLE I - Summaries of studies appraised in this review No Author Year Country Condition/patients Sample Study design Molecular diagnosis methods Reference 1 Moutaouakkil et al 2022 China Children diagnosed with Staphylococcus aureus OAI Blood cultures, articular fluids, synovial tissues and/or bone fragments Prospective study Multiplex polymerase chain reaction (6) 2 Jin et al 2022 231 samples 2,822 patients with positive blood cultures exclusively showing GPCC on Gram stain were included Prospective study Xpert MRSA/ SA BC assay (8) 5 Choi et al 2021 South Korea 26 children aged <15 years diagnosed with SSSS Involved area of the skin, the presence of Nikolsky’s sign, and the status of desquamation n/a PCR (9) 6 Anafo et al 2021
    keywords: aureus; crossref; detection; diagnosis; dna; et al; methicillin; microbiol; mlst; molecular; mrsa; pcr; pubmed; resistance; review; sccmec; staphylococcus; staphylococcus aureus; study; typing
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        item: #94 of 101
          id: dti-2529
      author: Khemla, Supphachoke; Meesing, Atibordee; Sribenjalux, Wantin; Chetchotisakd, Ploenchan
       title: Lipid profiles of people with human immunodeficiency virus with dyslipidemia after switching from efavirenz to dolutegravir
        date: 2023-04-28
       words: 5812
      flesch: 62
     summary: 6.03 ± 33.56 −2.35, 14.41 0.156 LDL- cholesterol 131.88 ± 36.17 106.17 ± 31.37 110.88 ± 30.72 −25.70 ± 23.31 −31.53, −19.88 <0.001 −21.00 ± 29.41 −28.34, −13.65 <0.001 4.71 ± 26.78 −1.98, 11.39 0.165 HDL- cholesterol 54.45 ± 13.56 48.20 ± 12.48 50.23 ± 13.23 −6.24 ± 7.52 −8.12, −4.36 <0.001 −4.21 ± 8.12 −6.24, −2.18 <0.001 2.03 ± 6.13 0.49, 3.56 0.010 Triglycerides 181.64 ± 94.12 145.47 ± 77.75 131.94 ± 75.28 −36.17 ± 89.88 −58.62, −13.71 0.002 −49.70 ± 67.40 −66.54, −32.86 <0.001 13.53 ± 67.79 −30.46, 3.40 0.115 Cholesterol/ HDL 4.00 ± 0.93 3.69 ± 1.01 3.69 ± 1.06 −0.31 ± 0.61 −0.46, −0.15 <0.001
    keywords: cholesterol; efv; hiv; lipid; mean; patients; pubmed; study; treatment; week; weight
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        item: #95 of 101
          id: dti-2545
      author: Kothari, Vijay
       title: AMR research: a perspective from personal experience
        date: 2022-12-23
       words: 1534
      flesch: 40
     summary: If people with such exaggerated simplistic perception of AMR research happen to head some academic institute, they may do even more harm by indirectly dissuad- ing brilliant young minds to join AMR labs. Recently while presenting a grant proposal involving use of C. elegans as a model host, and implementing whole- transcriptome analysis of bacterial pathogen treated with certain anti-pathogenic herbal formulation for novel tar- get identification, I had to face these naughty comments from the grant-reviewing panel: A. “Instead of working with C. elegans, do experiments directly with higher animals”: Despite arguing that use of simpler organisms like C. elegans at an early stage can reduce animal sacrifice at later stages, and inform- ing the committee of few hundred papers citing C. ele- gans as a valid and useful model for AMR research, I failed to convince the committee (or the committee failed to understand the value of C. elegans in AMR research).
    keywords: amr; anti; committee; research; surveillance
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        item: #96 of 101
          id: dti-2548
      author: Iriti, Marcello
       title: Natural Products & Phytotherapeutics: why a new section?
        date: 2023-01-16
       words: 970
      flesch: 39
     summary: According to one of the most authoritative reports focus- ing on natural products as sources of new drugs, the use of natural products and their synthetic derivatives is still piv- otal in the discovery of new drugs (1). Indeed, among the new drugs approved (N = 1881) in the last four decades, about 25% are natural products (Fig. 1A).
    keywords: anticancer; drugs; phytotherapeutics; products
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        item: #97 of 101
          id: dti-2573
      author: Rattanathanoo, Ratchanon; Chindaprasirt, Jarin; Boonsawat, Watchara; Limpawattana, Panita; Khamsai, Sittichai; Sawanyawisuth, Kittisak
       title: Are calcium channel blockers related to lung cancer?
        date: 2023-05-19
       words: 3402
      flesch: 57
     summary: The case-control study did not state how lung cancer diagnosis was made and sig- nificant factors in this study, namely dyslipidemia and family history of lung cancer, were not studied (12). Association between family history and lung cancer risk among Chinese women in Singapore.
    keywords: cancer; ccb; crossref; factors; lung; lung cancer; patients; pubmed; risk; study
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        item: #98 of 101
          id: dti-2574
      author: Zambelli, Vanessa; Murphy, Emma J.; Del Vecchio, Paolo; Rizzi, Laura; Fumagalli, Roberto; Rezoagli, Emanuele; Bellani, Giacomo
       title: Treatment with levosimendan in an experimental model of early ventilator-induced diaphragmatic dysfunction
        date: 2023-04-13
       words: 4739
      flesch: 52
     summary: VIDD: MV + no treatment (n = 12); VIDD+Levo: MV + levosimendan treatment (n = 8). MV = mechanical ventilation; VIDD = ventilator-induced diaphragmatic dysfunction.
    keywords: care; crossref; diaphragm; levosimendan; muscle; pubmed; treatment; vidd
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        item: #99 of 101
          id: dti-2583
      author: Khan, Safiya Fatima; Shetty, Bhavya; Fazal, Ibrahim; Mustafa Khan, Asim; Muzaffar Mir, Faheem; Moothedath, Muhamood; VJ, Reshma; Muhamood, Muhaseena
       title: Licorice as a herbal extract in periodontal therapy
        date: 2023-06-05
       words: 5581
      flesch: 43
     summary: In vitro study Licorice extract showed anti-inflammatory effects by reducing the IL-1b, -6, -8 and TNF-α responses of macrophages induced by LPS. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicro- bial, and anti-adherence effects that are beneficial against periodontal disease.
    keywords: acid; activity; crossref; disease; effects; extract; glabra; glabridin; glycyrrhiza; herbal; host; licorice; periodontal; periodontitis; potential; pubmed; study; therapy; treatment
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        item: #100 of 101
          id: dti-2593
      author: Inno, Alessandro; Fabiana Marchetti; Matteo Valerio; Niccolò Giaj Levra; Filippo Alongi; Giovanni Foti; Stefania Gori
       title: Activity of sotorasib against brain metastases from NSCLC harboring KRAS p.G12C mutation: a case report
        date: 2023-06-20
       words: 1490
      flesch: 47
     summary: Full information is available at www.aboutscience.eu Activity of sotorasib against brain metastases from NSCLC harboring KRAS p.G12C mutation: a case report Alessandro Inno1, Fabiana Marchetti1, Matteo Valerio1, Niccolò Giaj Levra2, Filippo Alongi2, Giovanni Foti3, Stefania Gori1 1Medical Oncology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella (VR) - Italy 2Advanced Radiation Oncology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella (VR) - Italy 3Radiology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella (VR) - Italy ABSTRACT In the CodeBreaK 100 phase 2 study, sotorasib was active for patients with metastatic non-small cell lung cancer (NSCLC) harboring Kirsten rat sarcoma viral oncogene homologue (KRAS) However, patients with untreated and/or active brain metastases were excluded from the trial, and the activity of sotorasib in the setting of brain metastases should be further investigated.
    keywords: brain; kras; metastases; nsclc; sotorasib
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        item: #101 of 101
          id: dti-2596
      author: Bumbrah, Gurvinder Singh; Jain, Sarika; Fatima, Zeeshan; Hameed, Saif
       title: Efficacy of LAMP assay for Mycobacterial spp. detection to prevent treatment delays and onset of drug resistance: a systematic review and meta-analysis
        date: 2023-06-07
       words: 8532
      flesch: 63
     summary: Table II - Accuracy and precision of the included studies (n = 30) S. No. Study Accuracy Precision 1 Boehme et al (2007) 98.68 97.74 2 Pandey et al (2008) 94.00 93.75 3 Poudel et al (2009) 95.54 94.17 4 Geojith et al (2011) 60.71 94.44 5 George et al (2011) 94.36 93.93 6 Mitarai et al (2011) 88.75 95.60 7 Nagdev et al (2011) 85.18 88.23 8 Sethi et al (2013) 87.96 100.00 9 Cao et al (2015) 94.30 95.14 10 Joon et al (2015) 92.06 54.90 11 Moon et al (2015) 94.71 91.42 12 Bojang et al (2016) 95.86 90.74 13 Gray et al (2016) 93.64 86.42 14 Kaku et al (2016) 94.49 96.40 15 Modi et al (2016) 97.60 100.00 16 Sharma et al (2016) 92.94 100.00 17 Joon et al (2017) 97.03 73.91 18 Reddy et al (2017) 91.07 87.50 19 Sharma et al (2016) 93.57 100.00 20 Yadav et al (2017) 99.33 96.47 21 Kim et al (2018) 94.13 100.00 22 Nguyen et al (2018) 91.81 39.47 23 Perera et al (2018) 89.13 86.11 24 Joon et al (2019) 98.13 86.66 25 Phetsuksiri et al (2019) 98.67 99.31 26 Punati et al (2019) 97.68 90.52 27 Rajput et al (2019) 79.22 90.90 28 Han et al (2020) 37.73 98.33 29 Phetsuksiri et al (2020) 87.69 83.21 30 Phetsuksiri et al (2020) 96.56 100.00 values ranged from 0.67 to 1.00 (Fig. 6). Park KS, Kim JY, Lee JW, et al.
    keywords: amplification; analysis; crossref; detection; diagnosis; isothermal; lamp; m et; pubmed; studies; tuberculosis
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