id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dti-1319	R.R, Resende; H.A.M, Torres; K.K, Yuahasi; P, Majumder; H, Ulrich	Delivery Systems for In Vivo Use of Nucleic Acid Drugs	2007	14	.pdf	application/pdf	10916	852	57	In many cases 2′-F-modifi ed pyrimidines are employed in the in vitro transcription reaction to improve nuclease-resistance of generated RNA molecules (reviewed by Ulrich et al. 2004). The anti-TAR RNA aptamer (Ducongé and Toulmé, 1999) was optimized by chemical modi- fi cations towards improved stability regarding nuclease resistance and decreased trans-activation of transcription in cell nuclei extract assays (Darfeuille et al. 2002a; Darfeuille et al. 2002b; Darfeuille et al. 2004; Kolb et al. 2005; Toulmé et al. 2001).	cache/dti-1319.pdf	txt/dti-1319.txt