id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dti-1335	Wilczak, Nadine; Keyser, Jacques De; Chesik, Daniel	Targeting Insulin-Like Growth Factor-1 Signaling into the Central Nervous System for Promoting Myelin Repair	2008	8	.pdf	application/pdf	6086	440	55	Other studies have shown that systemic application of IGF-1 in acute demyelinating experimental autoim- mune encephalomyelitis (EAE), an animal model for MS, signifi cantly reduced the number and area of the demyelinated lesions in the spinal cord (Liu and Yao, 1995; Yao et al. 1995). The MAP kinase pathway is often associated in proliferation and differentiation (Kim et al. 1997), whereas the Akt pathway is induced in IGF-1 mediated cell survival (Brunet et al. 1999) and protection from apoptosis (Kermer et al. 2000).	cache/dti-1335.pdf	txt/dti-1335.txt