id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dti-1419	Hydery, Tasmina; Coppenrath, Valerie Azzopardi	A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria	2019	8	.pdf	application/pdf	6245	323	55	Studies in adult PKU patients have shown a variation in phenylalanine levels can be observed without any change in treatment.20 In clinical trials, the response to sapropterin treatment was defined as a 30% reduction in blood phenylalanine concentration from base- line.21 The assessment of blood phenylalanine concentrations may also be indicative of patient adherence to therapy.22 Poor adherence can manifest as failure to take medical foods or pre- scribed medications, and missing regular clinic appointments or blood phenylalanine testing.23	cache/dti-1419.pdf	txt/dti-1419.txt