id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
dti-1420	Fragkou, Paraskevi; Souli, Maria; Theochari, Maria; Kontopoulou, Christina; Loukides, Stelios; Koumarianou, Anna	A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab	2016	4	.pdf	application/pdf	2759	168	44	When COP is suspected in cancer patients, differential diagnoses that need to be considered include disease progres- sion, cardiogenic edema, radiation pneumonitis, allergies, pulmonary hemorrhage, and infections that cause diffuse inter- stitial infiltrates in the lungs such as gram-negative or gram- positive bacteria, fungi (Aspergillus, Candida, and P. jirovecii), parasites (Toxoplasma gondii), or viruses (herpes simplex, vari- cella zoster, and cytomegalovirus).17 On the other hand, pneumonitis in cancer patients may hold a heterogeneous pathological background based on vari- ous antineoplastic agents including chemotherapy, such as taxanes, targeted therapy, such as everolimus, and Mabs, such as rituximab, a chimeric IgG1.17 In retrospective analysis of patients with non-Hodgkin lymphoma treated with rituximab, 8 of 23 patients, diagnosed with COP and treated with corticosteroids, died, indicat- ing that COP although rare may become a fatal pulmonary toxicity and the oncologists or internists must maintain a high index of suspicion to recognize this complication early. Introduction New monoclonal antibodies (Mabs) targeting the immune checkpoint blockade have revolutionized the treatment of advanced melanoma patients.	cache/dti-1420.pdf	txt/dti-1420.txt