id	sid	eid	entity	type
dti-1419	1	1	13	CARDINAL
dti-1419	2	1	2019	DATE
dti-1419	2	2	10.1177/1177392819857089	CARDINAL
dti-1419	2	3	4.0	CARDINAL
dti-1419	3	1	about 1	CARDINAL
dti-1419	3	2	13 500	CARDINAL
dti-1419	3	3	19 000	CARDINAL
dti-1419	3	4	united states.1	GPE
dti-1419	6	1	pah).2	PERSON
dti-1419	6	2	1200	CARDINAL
dti-1419	7	1	600	CARDINAL
dti-1419	7	2	360-600	CARDINAL
dti-1419	7	3	120	CARDINAL
dti-1419	7	4	360	CARDINAL
dti-1419	7	5	120	CARDINAL
dti-1419	7	6	600	CARDINAL
dti-1419	7	7	van wegberg	PERSON
dti-1419	7	8	macdonald	PERSON
dti-1419	7	9	2017	DATE
dti-1419	9	1	fda	ORG
dti-1419	9	2	december 13, 2007	DATE
dti-1419	9	3	first	ORDINAL
dti-1419	9	4	hydery1	ORG
dti-1419	9	5	valerie azzopardi	PERSON
dti-1419	10	1	umass medical school	ORG
dti-1419	10	2	shrewsbury	GPE
dti-1419	10	3	ma, usa	ORG
dti-1419	11	1	2school	CARDINAL
dti-1419	11	2	massachusetts college	ORG
dti-1419	11	3	ma, usa.	ORG
dti-1419	12	1	1946-september 1, 2018	DATE
dti-1419	13	1	english	LANGUAGE
dti-1419	15	1	approximately 50% to 70%	PERCENT
dti-1419	18	1	first	ORDINAL
dti-1419	19	1	600	CARDINAL
dti-1419	20	1	may 22, 2019	DATE
dti-1419	21	1	may 23, 2019	DATE
dti-1419	24	1	tasmina hydery	ORG
dti-1419	24	2	umass medical school	ORG
dti-1419	24	3	shrewsbury	GPE
dti-1419	24	4	01545	DATE
dti-1419	24	5	usa.	GPE
dti-1419	24	6	857089	DATE
dti-1419	24	7	2	CARDINAL
dti-1419	24	8	pku	ORG
dti-1419	24	9	sapropterin	PERSON
dti-1419	25	1	approximately 25% to 50%	PERCENT
dti-1419	25	2	3	CARDINAL
dti-1419	25	3	2013	DATE
dti-1419	25	4	fda	ORG
dti-1419	25	5	may 24, 2018	DATE
dti-1419	25	6	600	CARDINAL
dti-1419	27	1	1946-september 1, 2018	DATE
dti-1419	28	1	2	CARDINAL
dti-1419	30	1	english	LANGUAGE
dti-1419	33	1	melanin.13	PERSON
dti-1419	33	2	2	CARDINAL
dti-1419	34	1	pku	ORG
dti-1419	36	1	1	CARDINAL
dti-1419	37	1	1	CARDINAL
dti-1419	37	2	2	CARDINAL
dti-1419	38	1	first	ORDINAL
dti-1419	38	2	1	CARDINAL
dti-1419	38	3	the age of 18	DATE
dti-1419	38	4	1200	CARDINAL
dti-1419	39	1	1310	CARDINAL
dti-1419	39	2	26.4 kg/m2	QUANTITY
dti-1419	40	1	twenty-five	CARDINAL
dti-1419	40	2	7	CARDINAL
dti-1419	40	3	the united states	GPE
dti-1419	41	1	1	CARDINAL
dti-1419	43	1	daily	DATE
dti-1419	43	2	20	CARDINAL
dti-1419	43	3	40 mg median	QUANTITY
dti-1419	43	4	8 hours	TIME
dti-1419	43	5	±	CARDINAL
dti-1419	43	6	14.0 ± 16.3 mg/l 16.7 ± 19.5 mg	QUANTITY
dti-1419	43	7	±	CARDINAL
dti-1419	43	8	26.4 ±	CARDINAL
dti-1419	43	9	22.2 ±	QUANTITY
dti-1419	43	10	19.7 l	DATE
dti-1419	43	11	±	CARDINAL
dti-1419	43	12	0.39 ± 0.87	MONEY
dti-1419	43	13	l/h	ORG
dti-1419	43	14	1.25 ±	MONEY
dti-1419	43	15	l/h	DATE
dti-1419	43	16	half	CARDINAL
dti-1419	43	17	±	CARDINAL
dti-1419	43	18	47	CARDINAL
dti-1419	43	19	±	CARDINAL
dti-1419	43	20	11.2 ± 9.0 mg/l 10.4 ± 12.7 mg/l	QUANTITY
dti-1419	44	1	3	CARDINAL
dti-1419	44	2	the 30 days	DATE
dti-1419	44	3	twenty-five	CARDINAL
dti-1419	44	4	1	CARDINAL
dti-1419	44	5	5	CARDINAL
dti-1419	44	6	day 1	DATE
dti-1419	44	7	0.001	CARDINAL
dti-1419	44	8	0.003	CARDINAL
dti-1419	44	9	0.10	CARDINAL
dti-1419	44	10	0.03	CARDINAL
dti-1419	44	11	0.100 mg/kg	QUANTITY
dti-1419	45	1	42 days	DATE
dti-1419	46	1	the 0.1 mg/kg	PRODUCT
dti-1419	46	2	1113 to 575	CARDINAL
dti-1419	46	3	48.3%	PERCENT
dti-1419	46	4	day 6	DATE
dti-1419	47	1	day 7 to day 21	DATE
dti-1419	47	2	2	CARDINAL
dti-1419	47	3	3	CARDINAL
dti-1419	47	4	2	CARDINAL
dti-1419	48	1	pal-002	PERSON
dti-1419	48	2	40	CARDINAL
dti-1419	49	1	8-week	DATE
dti-1419	49	2	weekly	DATE
dti-1419	49	3	8-week	DATE
dti-1419	49	4	weekly	DATE
dti-1419	50	1	0.001 to 0.1 mg/kg	QUANTITY
dti-1419	52	1	2	CARDINAL
dti-1419	54	1	1	CARDINAL
dti-1419	54	2	42 days 0.001	DATE
dti-1419	54	3	0.003	CARDINAL
dti-1419	54	4	0.10	CARDINAL
dti-1419	54	5	0.03	CARDINAL
dti-1419	54	6	0.100 mg/kg	QUANTITY
dti-1419	54	7	25 48.3%	PERCENT
dti-1419	54	8	from day 4 to 7	DATE
dti-1419	54	9	2	CARDINAL
dti-1419	54	10	16 weeks	DATE
dti-1419	54	11	0.001-0.1 mg/kg	QUANTITY
dti-1419	54	12	5	CARDINAL
dti-1419	54	13	40	CARDINAL
dti-1419	54	14	5%	PERCENT
dti-1419	54	15	2	CARDINAL
dti-1419	54	16	aes 2	ORG
dti-1419	55	1	13 weeks	DATE
dti-1419	55	2	0.06-0.8 mg/kg	QUANTITY
dti-1419	55	3	16	CARDINAL
dti-1419	55	4	6.25%	PERCENT
dti-1419	55	5	1	CARDINAL
dti-1419	55	6	aes 2	ORG
dti-1419	55	7	165-205	CARDINAL
dti-1419	55	8	24 weeks	DATE
dti-1419	55	9	2.5 mg	TIME
dti-1419	55	10	weekly	DATE
dti-1419	55	11	4-8 weeks	DATE
dti-1419	55	12	75	CARDINAL
dti-1419	55	13	daily	DATE
dti-1419	55	14	24 46%	PERCENT
dti-1419	55	15	56%	PERCENT
dti-1419	55	16	54%	PERCENT
dti-1419	55	17	8.33%	PERCENT
dti-1419	55	18	2	CARDINAL
dti-1419	55	19	aes 2 nct00924703	ORG
dti-1419	55	20	2	CARDINAL
dti-1419	55	21	264 weeks	DATE
dti-1419	55	22	up to	CARDINAL
dti-1419	55	23	up to	CARDINAL
dti-1419	55	24	7	CARDINAL
dti-1419	55	25	68a 58.9%	PERCENT
dti-1419	55	26	48 weeks	DATE
dti-1419	55	27	72.3%	PERCENT
dti-1419	55	28	120 weeks	DATE
dti-1419	55	29	5.9%	PERCENT
dti-1419	55	30	4	CARDINAL
dti-1419	55	31	aes 3	ORG
dti-1419	55	32	24 months 2.5	DATE
dti-1419	55	33	daily	DATE
dti-1419	55	34	20 or 40 mg	QUANTITY
dti-1419	55	35	daily	DATE
dti-1419	55	36	261 51.1%	PERCENT
dti-1419	55	37	12 months	DATE
dti-1419	55	38	68.7%	PERCENT
dti-1419	55	39	24 months	DATE
dti-1419	55	40	11%	PERCENT
dti-1419	55	41	29	CARDINAL
dti-1419	55	42	aes 3 nct01889862	ORG
dti-1419	55	43	1	CARDINAL
dti-1419	55	44	20	CARDINAL
dti-1419	55	45	daily	DATE
dti-1419	55	46	2	CARDINAL
dti-1419	55	47	8 weeks	DATE
dti-1419	55	48	20 mg	TIME
dti-1419	55	49	40	CARDINAL
dti-1419	55	50	daily	DATE
dti-1419	55	51	86	CARDINAL
dti-1419	55	52	62.6%	PERCENT
dti-1419	55	53	phe	ORG
dti-1419	55	54	20	CARDINAL
dti-1419	55	55	56.4%	PERCENT
dti-1419	55	56	phe	ORG
dti-1419	55	57	40	CARDINAL
dti-1419	56	1	aes	ORG
dti-1419	56	2	3	CARDINAL
dti-1419	56	3	20	CARDINAL
dti-1419	56	4	daily	DATE
dti-1419	56	5	4	CARDINAL
dti-1419	56	6	5-60 mg	QUANTITY
dti-1419	56	7	daily	DATE
dti-1419	56	8	aes	ORG
dti-1419	56	9	phe	ORG
dti-1419	57	1	2	CARDINAL
dti-1419	58	1	2	CARDINAL
dti-1419	59	1	4	CARDINAL
dti-1419	59	2	16	CARDINAL
dti-1419	60	1	5	CARDINAL
dti-1419	60	2	0.06	CARDINAL
dti-1419	60	3	the 13 weeks	DATE
dti-1419	62	1	at least 1	CARDINAL
dti-1419	62	2	ae	ORG
dti-1419	63	1	third	ORDINAL
dti-1419	63	2	2	CARDINAL
dti-1419	63	3	165	CARDINAL
dti-1419	64	1	24 weeks	DATE
dti-1419	65	1	the 6 months	DATE
dti-1419	65	2	the 4 months	DATE
dti-1419	67	1	4to	ORDINAL
dti-1419	67	2	8-week	DATE
dti-1419	67	3	2.5 mg	QUANTITY
dti-1419	68	1	4 weeks	DATE
dti-1419	68	2	⩽600 µmol	ORG
dti-1419	69	1	4 weeks	DATE
dti-1419	71	1	600	CARDINAL
dti-1419	71	2	75 mg	QUANTITY
dti-1419	72	1	7 d	MONEY
dti-1419	75	1	at least 1	CARDINAL
dti-1419	75	2	at least 1	CARDINAL
dti-1419	75	3	twenty-four	CARDINAL
dti-1419	75	4	11	CARDINAL
dti-1419	75	5	the first 24 weeks	DATE
dti-1419	75	6	13	CARDINAL
dti-1419	75	7	24 weeks	DATE
dti-1419	76	1	age of approximately 29 years	DATE
dti-1419	76	2	1134.8	CARDINAL
dti-1419	76	3	1197.5	CARDINAL
dti-1419	77	1	64.6 kg	QUANTITY
dti-1419	77	2	86.4 kg	QUANTITY
dti-1419	78	1	24-week	DATE
dti-1419	78	2	64.7 mg	QUANTITY
dti-1419	78	3	89.4 mg	QUANTITY
dti-1419	79	1	600	CARDINAL
dti-1419	80	1	627	CARDINAL
dti-1419	80	2	56%	PERCENT
dti-1419	80	3	± 36%	PERCENT
dti-1419	81	1	120	CARDINAL
dti-1419	81	2	24-week	DATE
dti-1419	83	1	ten	CARDINAL
dti-1419	83	2	13	CARDINAL
dti-1419	83	3	⩽600 µmol/l by	ORG
dti-1419	83	4	48.17	CARDINAL
dti-1419	83	5	3	CARDINAL
dti-1419	83	6	2	CARDINAL
dti-1419	86	1	between 60 and 600	CARDINAL
dti-1419	86	2	aes	ORG
dti-1419	86	3	2.5 to 375	CARDINAL
dti-1419	86	4	0.001 to 5 mg/kg	QUANTITY
dti-1419	86	5	weekly	DATE
dti-1419	86	6	375 mg	QUANTITY
dti-1419	87	1	1	CARDINAL
dti-1419	87	2	at least 1	CARDINAL
dti-1419	87	3	sixty-eight	CARDINAL
dti-1419	87	4	80	CARDINAL
dti-1419	88	1	1022.4	CARDINAL
dti-1419	88	2	daily	DATE
dti-1419	89	1	5.3 mg	QUANTITY
dti-1419	89	2	6.8 mg/d	QUANTITY
dti-1419	89	3	26.2 mg	QUANTITY
dti-1419	90	1	week 48 to week 120	DATE
dti-1419	91	1	2	CARDINAL
dti-1419	91	2	approximately 3.4 years	DATE
dti-1419	92	1	more than half	CARDINAL
dti-1419	92	2	58.9%	PERCENT
dti-1419	92	3	week 48	DATE
dti-1419	92	4	72%	PERCENT
dti-1419	92	5	week 120	DATE
dti-1419	92	6	1022.4	CARDINAL
dti-1419	92	7	541.6	CARDINAL
dti-1419	92	8	48	DATE
dti-1419	92	9	372	CARDINAL
dti-1419	92	10	one-third	CARDINAL
dti-1419	92	11	36.8%	PERCENT
dti-1419	93	1	5.9%	PERCENT
dti-1419	93	2	aes	ORG
dti-1419	94	1	4	CARDINAL
dti-1419	94	2	aes	ORG
dti-1419	95	1	2	CARDINAL
dti-1419	95	2	3	CARDINAL
dti-1419	95	3	3	CARDINAL
dti-1419	96	1	1	CARDINAL
dti-1419	96	2	2	CARDINAL
dti-1419	97	1	600	CARDINAL
dti-1419	97	2	at least 6 months	DATE
dti-1419	99	1	2.5	CARDINAL
dti-1419	99	2	4 weeks	DATE
dti-1419	100	1	20 mg	QUANTITY
dti-1419	100	2	5 to 30 weeks	DATE
dti-1419	101	1	the 20 mg/d	QUANTITY
dti-1419	101	2	2.5 mg	CARDINAL
dti-1419	101	3	weekly	DATE
dti-1419	101	4	10	CARDINAL
dti-1419	101	5	weekly	DATE
dti-1419	101	6	10	CARDINAL
dti-1419	101	7	weekly	DATE
dti-1419	101	8	10	CARDINAL
dti-1419	101	9	4	CARDINAL
dti-1419	101	10	weekly	DATE
dti-1419	101	11	10	CARDINAL
dti-1419	101	12	20	CARDINAL
dti-1419	102	1	24 to 36 weeks	DATE
dti-1419	103	1	261	CARDINAL
dti-1419	103	2	131	CARDINAL
dti-1419	103	3	the 20 mg	QUANTITY
dti-1419	103	4	130	CARDINAL
dti-1419	103	5	the 40 mg	QUANTITY
dti-1419	104	1	age of approximately 30 years	DATE
dti-1419	104	2	approximately half	CARDINAL
dti-1419	105	1	1232.7	CARDINAL
dti-1419	105	2	weeks	DATE
dti-1419	105	3	11.5	CARDINAL
dti-1419	105	4	14	CARDINAL
dti-1419	105	5	the 20 mg/d and 40 mg	QUANTITY
dti-1419	105	6	51.1%	PERCENT
dti-1419	105	7	564.5	CARDINAL
dti-1419	105	8	12 months	DATE
dti-1419	105	9	68.7%	PERCENT
dti-1419	105	10	311.4	CARDINAL
dti-1419	105	11	24 months	DATE
dti-1419	107	1	at least 1	CARDINAL
dti-1419	108	1	99%	PERCENT
dti-1419	108	2	96%	PERCENT
dti-1419	110	1	aes	ORG
dti-1419	110	2	70.5%	PERCENT
dti-1419	110	3	62.1%	PERCENT
dti-1419	110	4	47.9%	PERCENT
dti-1419	110	5	47.1%	PERCENT
dti-1419	111	1	aes	ORG
dti-1419	111	2	2.7%	PERCENT
dti-1419	111	3	2.7%	PERCENT
dti-1419	111	4	1.1%	PERCENT
dti-1419	111	5	0.8%	PERCENT
dti-1419	112	1	twelve	CARDINAL
dti-1419	112	2	4.6%	PERCENT
dti-1419	112	3	1	CARDINAL
dti-1419	113	1	1.8 minutes	TIME
dti-1419	113	2	the first 50 days	DATE
dti-1419	114	1	1	CARDINAL
dti-1419	114	2	20 mg	QUANTITY
dti-1419	114	3	40 mg	QUANTITY
dti-1419	114	4	daily	DATE
dti-1419	115	1	2	CARDINAL
dti-1419	116	1	3	CARDINAL
dti-1419	116	2	4	CARDINAL
dti-1419	117	1	4	CARDINAL
dti-1419	117	2	5 to 60	CARDINAL
dti-1419	117	3	1	CARDINAL
dti-1419	117	4	2	CARDINAL
dti-1419	118	1	an additional 9	CARDINAL
dti-1419	119	1	(either 20	CARDINAL
dti-1419	119	2	20 mg	QUANTITY
dti-1419	119	3	40 mg	QUANTITY
dti-1419	119	4	40	DATE
dti-1419	119	5	22%	PERCENT
dti-1419	119	6	40	DATE
dti-1419	120	1	8 weeks	DATE
dti-1419	120	2	503.9559	CARDINAL
dti-1419	120	3	563.9-1509	CARDINAL
dti-1419	120	4	20	CARDINAL
dti-1419	120	5	508.21164.4	CARDINAL
dti-1419	120	6	40	CARDINAL
dti-1419	121	1	3 months	DATE
dti-1419	121	2	1	CARDINAL
dti-1419	121	3	3	CARDINAL
dti-1419	122	1	aes	ORG
dti-1419	123	1	2.5 mg	QUANTITY
dti-1419	123	2	weekly	DATE
dti-1419	123	3	4 weeks	DATE
dti-1419	124	1	at least 5 weeks	DATE
dti-1419	124	2	20	CARDINAL
dti-1419	124	3	daily	DATE
dti-1419	127	1	30%	PERCENT
dti-1419	127	2	20%	PERCENT
dti-1419	127	3	⩽600 µmol	PERSON
dti-1419	127	4	24 weeks	DATE
dti-1419	128	1	40	CARDINAL
dti-1419	129	1	16 weeks	DATE
dti-1419	130	1	6	CARDINAL
dti-1419	130	2	30	CARDINAL
dti-1419	131	1	at least 60 minutes	TIME
dti-1419	134	1	igg	ORG
dti-1419	136	1	biomarin	NORP
dti-1419	136	2	125	CARDINAL
dti-1419	136	3	the united states	GPE
dti-1419	136	4	45	CARDINAL
dti-1419	136	5	pku clinics	ORG
dti-1419	137	1	360	CARDINAL
dti-1419	137	2	15%	PERCENT
dti-1419	137	3	18 to 29 years	DATE
dti-1419	137	4	20%	PERCENT
dti-1419	137	5	30+ years	DATE
dti-1419	137	6	1200	CARDINAL
dti-1419	140	1	pku	ORG
dti-1419	142	1	pegvaliase	ORG
dti-1419	144	1	management”11	ORG
dti-1419	145	1	dietician.15–19	PRODUCT
dti-1419	145	2	thomas et al	PERSON
dti-1419	145	3	26.3	CARDINAL
dti-1419	145	4	18.4	CARDINAL
dti-1419	145	5	1700.2	CARDINAL
dti-1419	147	1	only 25% to 50%	PERCENT
dti-1419	148	1	2015	DATE
dti-1419	148	2	the national pku alliance	ORG
dti-1419	148	3	the united states	GPE
dti-1419	150	1	approximately 6%	PERCENT
dti-1419	151	1	91%	PERCENT
dti-1419	152	1	facility.27	CARDINAL
dti-1419	154	1	7	CARDINAL
dti-1419	155	1	june 2018	DATE
dti-1419	156	1	3	CARDINAL
dti-1419	156	2	2.5 mg/0.5 ml	QUANTITY
dti-1419	156	3	10 mg/0.5 ml	QUANTITY
dti-1419	156	4	20 mg/ml	QUANTITY
dti-1419	156	5	100	CARDINAL
dti-1419	156	6	us$44.28	ORG
dti-1419	156	7	30-day	DATE
dti-1419	156	8	70 kg	QUANTITY
dti-1419	156	9	20 mg/kg	QUANTITY
dti-1419	156	10	40 mg	QUANTITY
dti-1419	156	11	daily	DATE
dti-1419	156	12	136	CARDINAL
dti-1419	157	1	biomarin	NORP
dti-1419	157	2	000 per year	DATE
dti-1419	157	3	1.5	CARDINAL
dti-1419	159	1	pegvaliase	ORG
dti-1419	159	2	3	CARDINAL
dti-1419	162	1	fda	ORG
dti-1419	162	2	600	CARDINAL
dti-1419	168	1	1	CARDINAL
dti-1419	168	2	health consensus development panel	ORG
dti-1419	169	1	national institutes of health consensus development conference	ORG
dti-1419	169	2	october 16–18, 2000	DATE
dti-1419	171	1	2001	DATE
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dti-1419	194	1	doi:10.1186/s13023-017-0685-2.	ORG
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dti-1419	224	1	sarkissian cn	PERSON
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dti-1419	257	1	novato	ORG
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dti-1419	264	1	jurecki	PERSON
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dti-1419	269	1	24	DATE
dti-1419	272	1	pdf	ORG
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dti-1419	274	1	25	CARDINAL
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dti-1419	279	1	26	CARDINAL
dti-1419	280	1	longo n	PERSON
dti-1419	282	1	2018	DATE
dti-1419	283	1	doi:10.1038	ORG
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dti-1419	292	1	ed	PERSON
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dti-1419	295	1	september 26, 2018	DATE
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