id	sid	tid	token	lemma	pos
dti-1294	1	1	untitled	untitled	ADJ
dti-1294	1	2	drug	drug	NOUN
dti-1294	1	3	target	target	NOUN
dti-1294	1	4	insights	insight	NOUN
dti-1294	1	5	2006	2006	NUM
dti-1294	1	6	:	:	PUNCT
dti-1294	1	7	1	1	NUM
dti-1294	1	8	29–34	29–34	NUM
dti-1294	1	9	29	29	NUM
dti-1294	1	10	correspondence	correspondence	NOUN
dti-1294	1	11	:	:	PUNCT
dti-1294	1	12	xing	xing	PROPN
dti-1294	2	1	qing	qing	PROPN
dti-1294	2	2	pan	pan	PROPN
dti-1294	2	3	please	please	INTJ
dti-1294	2	4	note	note	VERB
dti-1294	2	5	that	that	SCONJ
dti-1294	2	6	this	this	DET
dti-1294	2	7	article	article	NOUN
dti-1294	2	8	may	may	AUX
dti-1294	2	9	not	not	PART
dti-1294	2	10	be	be	AUX
dti-1294	2	11	used	use	VERB
dti-1294	2	12	for	for	ADP
dti-1294	2	13	commercial	commercial	ADJ
dti-1294	2	14	purposes	purpose	NOUN
dti-1294	2	15	.	.	PUNCT
dti-1294	3	1	for	for	ADP
dti-1294	3	2	further	further	ADJ
dti-1294	3	3	information	information	NOUN
dti-1294	3	4	please	please	INTJ
dti-1294	3	5	refer	refer	VERB
dti-1294	3	6	to	to	ADP
dti-1294	3	7	the	the	DET
dti-1294	3	8	copyright	copyright	NOUN
dti-1294	3	9	statement	statement	NOUN
dti-1294	3	10	at	at	ADP
dti-1294	3	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1294	3	12	original	original	ADJ
dti-1294	3	13	research	research	NOUN
dti-1294	3	14	the	the	DET
dti-1294	3	15	way	way	NOUN
dti-1294	3	16	that	that	PRON
dti-1294	3	17	pegyl	pegyl	ADJ
dti-1294	3	18	-	-	PUNCT
dti-1294	3	19	dspc	dspc	NOUN
dti-1294	3	20	liposomal	liposomal	NOUN
dti-1294	3	21	doxorubicin	doxorubicin	PROPN
dti-1294	3	22	particles	particle	NOUN
dti-1294	3	23	penetrate	penetrate	VERB
dti-1294	3	24	into	into	ADP
dti-1294	3	25	solid	solid	ADJ
dti-1294	3	26	tumor	tumor	NOUN
dti-1294	3	27	tissue	tissue	NOUN
dti-1294	3	28	xing	xing	PROPN
dti-1294	3	29	qing	qing	PROPN
dti-1294	3	30	pan1	pan1	PROPN
dti-1294	3	31	,	,	PUNCT
dti-1294	3	32	susie	susie	PROPN
dti-1294	3	33	jones2	jones2	PROPN
dti-1294	3	34	and	and	CCONJ
dti-1294	3	35	karen	karen	PROPN
dti-1294	3	36	cox2	cox2	PROPN
dti-1294	3	37	1college	1college	PROPN
dti-1294	3	38	of	of	ADP
dti-1294	3	39	pharmacy	pharmacy	NOUN
dti-1294	3	40	,	,	PUNCT
dti-1294	3	41	2department	2department	NUM
dti-1294	3	42	of	of	ADP
dti-1294	3	43	pathology	pathology	NOUN
dti-1294	3	44	,	,	PUNCT
dti-1294	3	45	medical	medical	ADJ
dti-1294	3	46	center	center	NOUN
dti-1294	3	47	.	.	PUNCT
dti-1294	4	1	the	the	DET
dti-1294	4	2	ohio	ohio	PROPN
dti-1294	4	3	state	state	PROPN
dti-1294	4	4	university	university	PROPN
dti-1294	4	5	,	,	PUNCT
dti-1294	4	6	columbus	columbus	PROPN
dti-1294	4	7	,	,	PUNCT
dti-1294	4	8	oh	oh	INTJ
dti-1294	4	9	43210	43210	NUM
dti-1294	4	10	.	.	PUNCT
dti-1294	5	1	abstract	abstract	ADJ
dti-1294	5	2	background	background	NOUN
dti-1294	5	3	:	:	PUNCT
dti-1294	5	4	for	for	ADP
dti-1294	5	5	enhancement	enhancement	NOUN
dti-1294	5	6	of	of	ADP
dti-1294	5	7	drug	drug	NOUN
dti-1294	5	8	effectiveness	effectiveness	NOUN
dti-1294	5	9	and	and	CCONJ
dti-1294	5	10	reduction	reduction	NOUN
dti-1294	5	11	of	of	ADP
dti-1294	5	12	drug	drug	NOUN
dti-1294	5	13	toxicity	toxicity	NOUN
dti-1294	5	14	,	,	PUNCT
dti-1294	5	15	liposomal	liposomal	ADJ
dti-1294	5	16	drugs	drug	NOUN
dti-1294	5	17	have	have	AUX
dti-1294	5	18	been	be	AUX
dti-1294	5	19	studied	study	VERB
dti-1294	5	20	in	in	ADP
dti-1294	5	21	laboratories	laboratory	NOUN
dti-1294	5	22	and	and	CCONJ
dti-1294	5	23	clinics	clinic	NOUN
dti-1294	5	24	for	for	ADP
dti-1294	5	25	decades	decade	NOUN
dti-1294	5	26	.	.	PUNCT
dti-1294	6	1	although	although	SCONJ
dti-1294	6	2	the	the	DET
dti-1294	6	3	results	result	NOUN
dti-1294	6	4	obtained	obtain	VERB
dti-1294	6	5	from	from	ADP
dti-1294	6	6	in	in	ADP
dti-1294	6	7	vitro	vitro	X
dti-1294	6	8	are	be	AUX
dti-1294	6	9	encouraging	encouraging	ADJ
dti-1294	6	10	,	,	PUNCT
dti-1294	6	11	but	but	CCONJ
dti-1294	6	12	the	the	DET
dti-1294	6	13	results	result	NOUN
dti-1294	6	14	from	from	ADP
dti-1294	6	15	in	in	ADP
dti-1294	6	16	vivo	vivo	ADJ
dti-1294	6	17	tests	test	NOUN
dti-1294	6	18	were	be	AUX
dti-1294	6	19	not	not	PART
dti-1294	6	20	satisfactory	satisfactory	ADJ
dti-1294	6	21	.	.	PUNCT
dti-1294	7	1	the	the	DET
dti-1294	7	2	main	main	ADJ
dti-1294	7	3	reasons	reason	NOUN
dti-1294	7	4	for	for	ADP
dti-1294	7	5	this	this	DET
dti-1294	7	6	situation	situation	NOUN
dti-1294	7	7	were	be	AUX
dti-1294	7	8	that	that	SCONJ
dti-1294	7	9	we	we	PRON
dti-1294	7	10	do	do	AUX
dti-1294	7	11	not	not	PART
dti-1294	7	12	have	have	VERB
dti-1294	7	13	enough	enough	ADJ
dti-1294	7	14	information	information	NOUN
dti-1294	7	15	about	about	ADP
dti-1294	7	16	the	the	DET
dti-1294	7	17	way	way	NOUN
dti-1294	7	18	how	how	SCONJ
dti-1294	7	19	liposomal	liposomal	ADJ
dti-1294	7	20	particles	particle	NOUN
dti-1294	7	21	penetrating	penetrate	VERB
dti-1294	7	22	into	into	ADP
dti-1294	7	23	solid	solid	ADJ
dti-1294	7	24	tumor	tumor	NOUN
dti-1294	7	25	tissue	tissue	NOUN
dti-1294	7	26	,	,	PUNCT
dti-1294	7	27	and	and	CCONJ
dti-1294	7	28	what	what	PRON
dti-1294	7	29	happening	happen	VERB
dti-1294	7	30	to	to	ADP
dti-1294	7	31	the	the	DET
dti-1294	7	32	liposome	liposome	NOUN
dti-1294	7	33	particles	particle	NOUN
dti-1294	7	34	after	after	SCONJ
dti-1294	7	35	they	they	PRON
dti-1294	7	36	got	get	VERB
dti-1294	7	37	into	into	ADP
dti-1294	7	38	the	the	DET
dti-1294	7	39	tumor	tumor	NOUN
dti-1294	7	40	tissue	tissue	NOUN
dti-1294	7	41	.	.	PUNCT
dti-1294	8	1	in	in	ADP
dti-1294	8	2	this	this	DET
dti-1294	8	3	paper	paper	NOUN
dti-1294	8	4	,	,	PUNCT
dti-1294	8	5	we	we	PRON
dti-1294	8	6	are	be	AUX
dti-1294	8	7	going	go	VERB
dti-1294	8	8	to	to	PART
dti-1294	8	9	report	report	VERB
dti-1294	8	10	the	the	DET
dti-1294	8	11	results	result	NOUN
dti-1294	8	12	from	from	ADP
dti-1294	8	13	our	our	PRON
dti-1294	8	14	observations	observation	NOUN
dti-1294	8	15	on	on	ADP
dti-1294	8	16	the	the	DET
dti-1294	8	17	way	way	NOUN
dti-1294	8	18	folic	folic	ADJ
dti-1294	8	19	acid	acid	NOUN
dti-1294	8	20	targeted	target	VERB
dti-1294	8	21	and	and	CCONJ
dti-1294	8	22	non	non	ADJ
dti-1294	8	23	-	-	ADJ
dti-1294	8	24	targeted	target	VERB
dti-1294	8	25	pegyl	pegyl	ADJ
dti-1294	8	26	-	-	PUNCT
dti-1294	8	27	dspc	dspc	NOUN
dti-1294	8	28	liposomal	liposomal	NOUN
dti-1294	8	29	doxorubicin	doxorubicin	PROPN
dti-1294	8	30	particles	particle	NOUN
dti-1294	8	31	penetrate	penetrate	VERB
dti-1294	8	32	into	into	ADP
dti-1294	8	33	solid	solid	ADJ
dti-1294	8	34	tumor	tumor	NOUN
dti-1294	8	35	tissue	tissue	NOUN
dti-1294	8	36	.	.	PUNCT
dti-1294	9	1	methods	method	NOUN
dti-1294	9	2	:	:	PUNCT
dti-1294	9	3	subcutaneous	subcutaneous	ADJ
dti-1294	9	4	transplanted	transplant	VERB
dti-1294	9	5	murine	murine	NOUN
dti-1294	9	6	l1210jf	l1210jf	VERB
dti-1294	9	7	solid	solid	ADJ
dti-1294	9	8	tumors	tumor	NOUN
dti-1294	9	9	in	in	ADP
dti-1294	9	10	mice	mouse	NOUN
dti-1294	9	11	were	be	AUX
dti-1294	9	12	used	use	VERB
dti-1294	9	13	as	as	ADP
dti-1294	9	14	a	a	DET
dti-1294	9	15	model	model	NOUN
dti-1294	9	16	.	.	PUNCT
dti-1294	10	1	pegyl	pegyl	PROPN
dti-1294	10	2	liposomal	liposomal	PROPN
dti-1294	10	3	doxorubicins	doxorubicin	NOUN
dti-1294	10	4	were	be	AUX
dti-1294	10	5	injected	inject	VERB
dti-1294	10	6	through	through	ADP
dti-1294	10	7	tail	tail	NOUN
dti-1294	10	8	venue	venue	NOUN
dti-1294	10	9	,	,	PUNCT
dti-1294	10	10	and	and	CCONJ
dti-1294	10	11	tumor	tumor	NOUN
dti-1294	10	12	tissue	tissue	NOUN
dti-1294	10	13	samples	sample	NOUN
dti-1294	10	14	were	be	AUX
dti-1294	10	15	collected	collect	VERB
dti-1294	10	16	at	at	ADP
dti-1294	10	17	special	special	ADJ
dti-1294	10	18	time	time	NOUN
dti-1294	10	19	points	point	NOUN
dti-1294	10	20	.	.	PUNCT
dti-1294	11	1	cryosections	cryosection	NOUN
dti-1294	11	2	were	be	AUX
dti-1294	11	3	cut	cut	VERB
dti-1294	11	4	and	and	CCONJ
dti-1294	11	5	dried	dry	VERB
dti-1294	11	6	by	by	ADP
dti-1294	11	7	a	a	DET
dti-1294	11	8	fl	fl	NOUN
dti-1294	11	9	owing	owe	VERB
dti-1294	11	10	of	of	ADP
dti-1294	11	11	air	air	NOUN
dti-1294	11	12	after	after	SCONJ
dti-1294	11	13	mounted	mount	VERB
dti-1294	11	14	on	on	ADP
dti-1294	11	15	the	the	DET
dti-1294	11	16	slides	slide	NOUN
dti-1294	11	17	right	right	ADV
dti-1294	11	18	away	away	ADV
dti-1294	11	19	.	.	PUNCT
dti-1294	12	1	then	then	ADV
dti-1294	12	2	the	the	DET
dti-1294	12	3	dried	dried	ADJ
dti-1294	12	4	cryosections	cryosection	NOUN
dti-1294	12	5	were	be	AUX
dti-1294	12	6	stained	stain	VERB
dti-1294	12	7	in	in	ADP
dti-1294	12	8	water	water	NOUN
dti-1294	12	9	systems	system	NOUN
dti-1294	12	10	;	;	PUNCT
dti-1294	12	11	the	the	DET
dti-1294	12	12	blood	blood	NOUN
dti-1294	12	13	vessel	vessel	NOUN
dti-1294	12	14	cells	cell	NOUN
dti-1294	12	15	were	be	AUX
dti-1294	12	16	stained	stain	VERB
dti-1294	12	17	with	with	ADP
dti-1294	12	18	green	green	PROPN
dti-1294	12	19	fl	fl	PROPN
dti-1294	12	20	uorescent	uorescent	ADJ
dti-1294	12	21	fitc	fitc	NOUN
dti-1294	12	22	labeled	label	VERB
dti-1294	12	23	antibody	antibody	NOUN
dti-1294	12	24	against	against	ADP
dti-1294	12	25	cd31	cd31	PROPN
dti-1294	12	26	antigen	antigen	PROPN
dti-1294	12	27	;	;	PUNCT
dti-1294	12	28	the	the	DET
dti-1294	12	29	nuclei	nucleus	NOUN
dti-1294	12	30	of	of	ADP
dti-1294	12	31	the	the	DET
dti-1294	12	32	living	live	VERB
dti-1294	12	33	cells	cell	NOUN
dti-1294	12	34	were	be	AUX
dti-1294	12	35	stained	stain	VERB
dti-1294	12	36	with	with	ADP
dti-1294	12	37	a	a	DET
dti-1294	12	38	blue	blue	ADJ
dti-1294	12	39	fl	fl	CCONJ
dti-1294	12	40	uorescent	uorescent	ADJ
dti-1294	12	41	dye	dye	NOUN
dti-1294	12	42	dapi	dapi	PROPN
dti-1294	12	43	.	.	PUNCT
dti-1294	13	1	since	since	SCONJ
dti-1294	13	2	the	the	DET
dti-1294	13	3	whole	whole	ADJ
dti-1294	13	4	procedure	procedure	NOUN
dti-1294	13	5	was	be	AUX
dti-1294	13	6	carried	carry	VERB
dti-1294	13	7	out	out	ADP
dti-1294	13	8	in	in	ADP
dti-1294	13	9	aquatic	aquatic	ADJ
dti-1294	13	10	system	system	NOUN
dti-1294	13	11	,	,	PUNCT
dti-1294	13	12	the	the	DET
dti-1294	13	13	red	red	ADJ
dti-1294	13	14	color	color	NOUN
dti-1294	13	15	fl	fl	PROPN
dti-1294	13	16	uorescent	uorescent	ADJ
dti-1294	13	17	liposomal	liposomal	PROPN
dti-1294	13	18	doxorubicin	doxorubicin	PROPN
dti-1294	13	19	particles	particle	NOUN
dti-1294	13	20	remain	remain	VERB
dti-1294	13	21	visible	visible	ADJ
dti-1294	13	22	under	under	ADP
dti-1294	13	23	fl	fl	ADP
dti-1294	13	24	uorescence	uorescence	NOUN
dti-1294	13	25	microscope	microscope	NOUN
dti-1294	13	26	.	.	PUNCT
dti-1294	14	1	results	result	NOUN
dti-1294	14	2	:	:	PUNCT
dti-1294	14	3	both	both	DET
dti-1294	14	4	folate	folate	VERB
dti-1294	14	5	conjugated	conjugated	ADJ
dti-1294	14	6	and	and	CCONJ
dti-1294	14	7	non	non	ADJ
dti-1294	14	8	-	-	ADJ
dti-1294	14	9	conjugated	conjugated	ADJ
dti-1294	14	10	pegyl	pegyl	ADJ
dti-1294	14	11	-	-	PUNCT
dti-1294	14	12	dspc	dspc	NOUN
dti-1294	14	13	liposomal	liposomal	NOUN
dti-1294	14	14	doxorubicin	doxorubicin	PROPN
dti-1294	14	15	particles	particle	NOUN
dti-1294	14	16	were	be	AUX
dti-1294	14	17	only	only	ADV
dti-1294	14	18	leaking	leak	VERB
dti-1294	14	19	out	out	ADP
dti-1294	14	20	from	from	ADP
dti-1294	14	21	the	the	DET
dti-1294	14	22	broken	broken	ADJ
dti-1294	14	23	holes	hole	NOUN
dti-1294	14	24	of	of	ADP
dti-1294	14	25	blood	blood	NOUN
dti-1294	14	26	vessels	vessel	NOUN
dti-1294	14	27	with	with	ADP
dti-1294	14	28	a	a	DET
dti-1294	14	29	special	special	ADJ
dti-1294	14	30	direction	direction	NOUN
dti-1294	14	31	and	and	CCONJ
dti-1294	14	32	spread	spread	VERB
dti-1294	14	33	out	out	ADP
dti-1294	14	34	for	for	ADP
dti-1294	14	35	a	a	DET
dti-1294	14	36	limited	limited	ADJ
dti-1294	14	37	distance	distance	NOUN
dti-1294	14	38	,	,	PUNCT
dti-1294	14	39	which	which	PRON
dti-1294	14	40	was	be	AUX
dti-1294	14	41	similar	similar	ADJ
dti-1294	14	42	to	to	ADP
dti-1294	14	43	the	the	DET
dti-1294	14	44	results	result	NOUN
dti-1294	14	45	showed	show	VERB
dti-1294	14	46	before	before	ADV
dti-1294	14	47	,	,	PUNCT
dti-1294	14	48	in	in	ADP
dti-1294	14	49	that	that	DET
dti-1294	14	50	observation	observation	NOUN
dti-1294	14	51	a	a	DET
dti-1294	14	52	latex	latex	NOUN
dti-1294	14	53	microsphere	microsphere	NOUN
dti-1294	14	54	sample	sample	PROPN
dti-1294	14	55	was	be	AUX
dti-1294	14	56	used	use	VERB
dti-1294	14	57	as	as	ADP
dti-1294	14	58	a	a	DET
dti-1294	14	59	model	model	NOUN
dti-1294	14	60	.	.	PUNCT
dti-1294	15	1	abbreviations	abbreviation	NOUN
dti-1294	15	2	:	:	PUNCT
dti-1294	15	3	dspc:1	dspc:1	ADJ
dti-1294	15	4	,	,	PUNCT
dti-1294	15	5	2	2	NUM
dti-1294	15	6	-	-	PUNCT
dti-1294	15	7	distearoyl	distearoyl	NOUN
dti-1294	15	8	-	-	PUNCT
dti-1294	15	9	sn	sn	NOUN
dti-1294	15	10	-	-	PUNCT
dti-1294	15	11	glycero-3	glycero-3	NOUN
dti-1294	15	12	-	-	PUNCT
dti-1294	15	13	phosphatylcholine	phosphatylcholine	NOUN
dti-1294	15	14	;	;	PUNCT
dti-1294	15	15	peg2000	peg2000	NOUN
dti-1294	15	16	-	-	PUNCT
dti-1294	15	17	dspc:1	dspc:1	NOUN
dti-1294	15	18	,	,	PUNCT
dti-1294	15	19	2	2	NUM
dti-1294	15	20	-	-	PUNCT
dti-1294	15	21	distearoyl	distearoyl	NOUN
dti-1294	15	22	-	-	PUNCT
dti-1294	15	23	sn	sn	NOUN
dti-1294	15	24	-	-	PUNCT
dti-1294	15	25	glycero	glycero	NOUN
dti-1294	15	26	3	3	NUM
dti-1294	15	27	-	-	PUNCT
dti-1294	15	28	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
dti-1294	15	29	-	-	PUNCT
dti-1294	15	30	n-[methoxy(polyethylene	n-[methoxy(polyethylene	NOUN
dti-1294	15	31	glycol)-2000	glycol)-2000	PROPN
dti-1294	15	32	]	]	X
dti-1294	15	33	;	;	PUNCT
dti-1294	15	34	folate	folate	NOUN
dti-1294	15	35	-	-	PUNCT
dti-1294	15	36	peg3400	peg3400	NOUN
dti-1294	15	37	-	-	PUNCT
dti-1294	15	38	dspe:1	dspe:1	NOUN
dti-1294	15	39	,	,	PUNCT
dti-1294	15	40	2	2	NUM
dti-1294	15	41	-	-	PUNCT
dti-1294	15	42	distearoyl	distearoyl	NOUN
dti-1294	15	43	-	-	PUNCT
dti-1294	15	44	sn	sn	NOUN
dti-1294	15	45	-	-	PUNCT
dti-1294	15	46	glycero3	glycero3	NOUN
dti-1294	15	47	-	-	PUNCT
dti-1294	15	48	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
dti-1294	15	49	-	-	PUNCT
dti-1294	15	50	n-[polyethylene	n-[polyethylene	ADJ
dti-1294	15	51	glycol-3400]-folate	glycol-3400]-folate	NOUN
dti-1294	15	52	.	.	PUNCT
dti-1294	16	1	keywords	keyword	NOUN
dti-1294	16	2	:	:	PUNCT
dti-1294	16	3	solid	solid	ADJ
dti-1294	16	4	tumor	tumor	NOUN
dti-1294	16	5	,	,	PUNCT
dti-1294	16	6	liposome	liposome	NOUN
dti-1294	16	7	particles	particle	NOUN
dti-1294	16	8	,	,	PUNCT
dti-1294	16	9	blood	blood	NOUN
dti-1294	16	10	vessel	vessel	NOUN
dti-1294	16	11	penetration	penetration	NOUN
dti-1294	16	12	.	.	PUNCT
dti-1294	17	1	introduction	introduction	NOUN
dti-1294	17	2	the	the	DET
dti-1294	17	3	toxicity	toxicity	NOUN
dti-1294	17	4	of	of	ADP
dti-1294	17	5	all	all	DET
dti-1294	17	6	the	the	DET
dti-1294	17	7	available	available	ADJ
dti-1294	17	8	anticancer	anticancer	NOUN
dti-1294	17	9	drugs	drug	NOUN
dti-1294	17	10	are	be	AUX
dti-1294	17	11	too	too	ADV
dti-1294	17	12	high	high	ADJ
dti-1294	17	13	,	,	PUNCT
dti-1294	17	14	commonly	commonly	ADV
dti-1294	17	15	the	the	DET
dti-1294	17	16	side	side	ADJ
dti-1294	17	17	effect	effect	NOUN
dti-1294	17	18	occurs	occur	VERB
dti-1294	17	19	at	at	ADP
dti-1294	17	20	their	their	PRON
dti-1294	17	21	functional	functional	ADJ
dti-1294	17	22	dosage	dosage	NOUN
dti-1294	17	23	.	.	PUNCT
dti-1294	18	1	liposomal	liposomal	ADJ
dti-1294	18	2	drugs	drug	NOUN
dti-1294	18	3	have	have	AUX
dti-1294	18	4	been	be	AUX
dti-1294	18	5	proven	prove	VERB
dti-1294	18	6	capable	capable	ADJ
dti-1294	18	7	of	of	ADP
dti-1294	18	8	changing	change	VERB
dti-1294	18	9	the	the	DET
dti-1294	18	10	drug	drug	NOUN
dti-1294	18	11	distribution	distribution	NOUN
dti-1294	18	12	in	in	ADP
dti-1294	18	13	vivo	vivo	NOUN
dti-1294	18	14	,	,	PUNCT
dti-1294	18	15	increasing	increase	VERB
dti-1294	18	16	the	the	DET
dti-1294	18	17	drug	drug	NOUN
dti-1294	18	18	effectiveness	effectiveness	NOUN
dti-1294	18	19	,	,	PUNCT
dti-1294	18	20	and	and	CCONJ
dti-1294	18	21	decreasing	decrease	VERB
dti-1294	18	22	the	the	DET
dti-1294	18	23	drug	drug	NOUN
dti-1294	18	24	toxicity	toxicity	NOUN
dti-1294	18	25	(	(	PUNCT
dti-1294	18	26	vail	vail	NOUN
dti-1294	18	27	et	et	PROPN
dti-1294	18	28	al	al	PROPN
dti-1294	18	29	.	.	PROPN
dti-1294	18	30	2004	2004	NUM
dti-1294	18	31	)	)	PUNCT
dti-1294	18	32	.	.	PUNCT
dti-1294	19	1	after	after	SCONJ
dti-1294	19	2	targeting	target	VERB
dti-1294	19	3	liposomal	liposomal	ADJ
dti-1294	19	4	drug	drug	NOUN
dti-1294	19	5	technique	technique	NOUN
dti-1294	19	6	was	be	AUX
dti-1294	19	7	developed	develop	VERB
dti-1294	19	8	,	,	PUNCT
dti-1294	19	9	we	we	PRON
dti-1294	19	10	can	can	AUX
dti-1294	19	11	see	see	VERB
dti-1294	19	12	in	in	ADP
dti-1294	19	13	culture	culture	NOUN
dti-1294	19	14	systems	system	NOUN
dti-1294	19	15	the	the	DET
dti-1294	19	16	liposome	liposome	NOUN
dti-1294	19	17	particles	particle	NOUN
dti-1294	19	18	binding	bind	VERB
dti-1294	19	19	onto	onto	ADP
dti-1294	19	20	tumor	tumor	NOUN
dti-1294	19	21	cell	cell	NOUN
dti-1294	19	22	surface	surface	NOUN
dti-1294	19	23	and	and	CCONJ
dti-1294	19	24	taken	take	VERB
dti-1294	19	25	up	up	ADP
dti-1294	19	26	by	by	ADP
dti-1294	19	27	the	the	DET
dti-1294	19	28	cells	cell	NOUN
dti-1294	19	29	quickly	quickly	ADV
dti-1294	19	30	.	.	PUNCT
dti-1294	20	1	however	however	ADV
dti-1294	20	2	,	,	PUNCT
dti-1294	20	3	at	at	ADP
dti-1294	20	4	the	the	DET
dti-1294	20	5	time	time	NOUN
dti-1294	20	6	the	the	DET
dti-1294	20	7	liposomes	liposome	NOUN
dti-1294	20	8	being	be	AUX
dti-1294	20	9	used	use	VERB
dti-1294	20	10	in	in	ADP
dti-1294	20	11	animals	animal	NOUN
dti-1294	20	12	,	,	PUNCT
dti-1294	20	13	the	the	DET
dti-1294	20	14	results	result	NOUN
dti-1294	20	15	were	be	AUX
dti-1294	20	16	showed	show	VERB
dti-1294	20	17	not	not	PART
dti-1294	20	18	as	as	ADV
dti-1294	20	19	good	good	ADJ
dti-1294	20	20	as	as	ADP
dti-1294	20	21	what	what	PRON
dti-1294	20	22	we	we	PRON
dti-1294	20	23	expected	expect	VERB
dti-1294	20	24	(	(	PUNCT
dti-1294	20	25	jain	jain	PROPN
dti-1294	20	26	,	,	PUNCT
dti-1294	20	27	2001	2001	NUM
dti-1294	20	28	;	;	PUNCT
dti-1294	20	29	nagayasu	nagayasu	PROPN
dti-1294	20	30	et	et	PROPN
dti-1294	20	31	al	al	PROPN
dti-1294	20	32	.	.	PROPN
dti-1294	20	33	1999	1999	NUM
dti-1294	20	34	;	;	PUNCT
dti-1294	20	35	patel	patel	PROPN
dti-1294	20	36	,	,	PUNCT
dti-1294	20	37	1996	1996	NUM
dti-1294	20	38	)	)	PUNCT
dti-1294	20	39	.	.	PUNCT
dti-1294	21	1	people	people	NOUN
dti-1294	21	2	were	be	AUX
dti-1294	21	3	too	too	ADV
dti-1294	21	4	busy	busy	ADJ
dti-1294	21	5	in	in	ADP
dti-1294	21	6	making	make	VERB
dti-1294	21	7	and	and	CCONJ
dti-1294	21	8	testing	test	VERB
dti-1294	21	9	different	different	ADJ
dti-1294	21	10	types	type	NOUN
dti-1294	21	11	of	of	ADP
dti-1294	21	12	liposomes	liposome	NOUN
dti-1294	21	13	,	,	PUNCT
dti-1294	21	14	number	number	NOUN
dti-1294	21	15	of	of	ADP
dti-1294	21	16	papers	paper	NOUN
dti-1294	21	17	even	even	ADV
dti-1294	21	18	only	only	ADV
dti-1294	21	19	reported	report	VERB
dti-1294	21	20	their	their	PRON
dti-1294	21	21	results	result	NOUN
dti-1294	21	22	without	without	ADP
dti-1294	21	23	animal	animal	NOUN
dti-1294	21	24	tests	test	NOUN
dti-1294	21	25	,	,	PUNCT
dti-1294	21	26	did	do	AUX
dti-1294	21	27	not	not	PART
dti-1294	21	28	pay	pay	VERB
dti-1294	21	29	enough	enough	ADJ
dti-1294	21	30	attention	attention	NOUN
dti-1294	21	31	to	to	ADP
dti-1294	21	32	the	the	DET
dti-1294	21	33	study	study	NOUN
dti-1294	21	34	of	of	ADP
dti-1294	21	35	knowing	know	VERB
dti-1294	21	36	further	far	ADV
dti-1294	21	37	about	about	ADP
dti-1294	21	38	the	the	DET
dti-1294	21	39	real	real	ADJ
dti-1294	21	40	processing	processing	NOUN
dti-1294	21	41	of	of	ADP
dti-1294	21	42	the	the	DET
dti-1294	21	43	liposomal	liposomal	ADJ
dti-1294	21	44	particles	particle	NOUN
dti-1294	21	45	in	in	ADP
dti-1294	21	46	the	the	DET
dti-1294	21	47	solid	solid	ADJ
dti-1294	21	48	tumor	tumor	NOUN
dti-1294	21	49	.	.	PUNCT
dti-1294	22	1	actually	actually	ADV
dti-1294	22	2	,	,	PUNCT
dti-1294	22	3	since	since	SCONJ
dti-1294	22	4	we	we	PRON
dti-1294	22	5	do	do	AUX
dti-1294	22	6	not	not	PART
dti-1294	22	7	know	know	VERB
dti-1294	22	8	the	the	DET
dti-1294	22	9	exact	exact	ADJ
dti-1294	22	10	way	way	NOUN
dti-1294	22	11	from	from	ADP
dti-1294	22	12	which	which	PRON
dti-1294	22	13	liposomal	liposomal	ADJ
dti-1294	22	14	particles	particle	NOUN
dti-1294	22	15	getting	get	VERB
dti-1294	22	16	into	into	ADP
dti-1294	22	17	solid	solid	ADJ
dti-1294	22	18	tumor	tumor	NOUN
dti-1294	22	19	tissue	tissue	NOUN
dti-1294	22	20	,	,	PUNCT
dti-1294	22	21	and	and	CCONJ
dti-1294	22	22	also	also	ADV
dti-1294	22	23	the	the	DET
dti-1294	22	24	fortune	fortune	NOUN
dti-1294	22	25	of	of	ADP
dti-1294	22	26	those	those	DET
dti-1294	22	27	liposomal	liposomal	ADJ
dti-1294	22	28	particles	particle	NOUN
dti-1294	22	29	after	after	SCONJ
dti-1294	22	30	they	they	PRON
dti-1294	22	31	got	get	VERB
dti-1294	22	32	inside	inside	ADP
dti-1294	22	33	the	the	DET
dti-1294	22	34	solid	solid	ADJ
dti-1294	22	35	tumor	tumor	NOUN
dti-1294	22	36	tissue	tissue	NOUN
dti-1294	22	37	.	.	PUNCT
dti-1294	23	1	clearly	clearly	ADV
dti-1294	23	2	,	,	PUNCT
dti-1294	23	3	it	it	PRON
dti-1294	23	4	is	be	AUX
dti-1294	23	5	not	not	PART
dti-1294	23	6	really	really	ADV
dti-1294	23	7	clear	clear	ADJ
dti-1294	23	8	what	what	PRON
dti-1294	23	9	is	be	AUX
dti-1294	23	10	the	the	DET
dti-1294	23	11	right	right	ADJ
dti-1294	23	12	direction	direction	NOUN
dti-1294	23	13	to	to	PART
dti-1294	23	14	further	far	ADV
dti-1294	23	15	improve	improve	VERB
dti-1294	23	16	the	the	DET
dti-1294	23	17	effectiveness	effectiveness	NOUN
dti-1294	23	18	of	of	ADP
dti-1294	23	19	liposomal	liposomal	ADJ
dti-1294	23	20	drugs	drug	NOUN
dti-1294	23	21	in	in	ADP
dti-1294	23	22	animal	animal	NOUN
dti-1294	23	23	or	or	CCONJ
dti-1294	23	24	clinic	clinic	NOUN
dti-1294	23	25	yet	yet	ADV
dti-1294	23	26	,	,	PUNCT
dti-1294	23	27	especially	especially	ADV
dti-1294	23	28	in	in	ADP
dti-1294	23	29	the	the	DET
dti-1294	23	30	targeted	target	VERB
dti-1294	23	31	liposomes	liposome	NOUN
dti-1294	23	32	and	and	CCONJ
dti-1294	23	33	the	the	DET
dti-1294	23	34	solid	solid	ADJ
dti-1294	23	35	tumor	tumor	NOUN
dti-1294	23	36	cases	case	NOUN
dti-1294	23	37	.	.	PUNCT
dti-1294	24	1	a	a	DET
dti-1294	24	2	number	number	NOUN
dti-1294	24	3	of	of	ADP
dti-1294	24	4	researchers	researcher	NOUN
dti-1294	24	5	have	have	AUX
dti-1294	24	6	done	do	VERB
dti-1294	24	7	a	a	DET
dti-1294	24	8	lot	lot	NOUN
dti-1294	24	9	of	of	ADP
dti-1294	24	10	studies	study	NOUN
dti-1294	24	11	in	in	ADP
dti-1294	24	12	this	this	DET
dti-1294	24	13	area	area	NOUN
dti-1294	24	14	with	with	ADP
dti-1294	24	15	various	various	ADJ
dti-1294	24	16	types	type	NOUN
dti-1294	24	17	of	of	ADP
dti-1294	24	18	equipment	equipment	NOUN
dti-1294	24	19	and	and	CCONJ
dti-1294	24	20	experimental	experimental	ADJ
dti-1294	24	21	designs	design	NOUN
dti-1294	24	22	(	(	PUNCT
dti-1294	24	23	lichtenbeld	lichtenbeld	VERB
dti-1294	24	24	et	et	PROPN
dti-1294	24	25	al	al	PROPN
dti-1294	24	26	.	.	PROPN
dti-1294	24	27	1996	1996	NUM
dti-1294	24	28	;	;	PUNCT
dti-1294	24	29	hashizume	hashizume	NOUN
dti-1294	24	30	et	et	PROPN
dti-1294	24	31	al	al	PROPN
dti-1294	24	32	.	.	PROPN
dti-1294	24	33	2000	2000	NUM
dti-1294	24	34	;	;	PUNCT
dti-1294	24	35	davorak	davorak	NOUN
dti-1294	24	36	et	et	PROPN
dti-1294	24	37	al	al	PROPN
dti-1294	24	38	.	.	PROPN
dti-1294	24	39	1999	1999	NUM
dti-1294	24	40	;	;	PUNCT
dti-1294	24	41	kohn	kohn	PROPN
dti-1294	24	42	et	et	PROPN
dti-1294	24	43	al	al	PROPN
dti-1294	24	44	.	.	PROPN
dti-1294	24	45	1992	1992	NUM
dti-1294	24	46	;	;	PUNCT
dti-1294	24	47	uster	uster	PROPN
dti-1294	24	48	et	et	PROPN
dti-1294	24	49	al	al	PROPN
dti-1294	24	50	.	.	PROPN
dti-1294	24	51	1998	1998	NUM
dti-1294	24	52	)	)	PUNCT
dti-1294	24	53	.	.	PUNCT
dti-1294	25	1	from	from	ADP
dti-1294	25	2	the	the	DET
dti-1294	25	3	results	result	NOUN
dti-1294	25	4	of	of	ADP
dti-1294	25	5	those	those	DET
dti-1294	25	6	studies	study	NOUN
dti-1294	25	7	we	we	PRON
dti-1294	25	8	agreed	agree	VERB
dti-1294	25	9	that	that	SCONJ
dti-1294	25	10	the	the	DET
dti-1294	25	11	liposomal	liposomal	ADJ
dti-1294	25	12	particles	particle	NOUN
dti-1294	25	13	may	may	AUX
dti-1294	25	14	pass	pass	VERB
dti-1294	25	15	through	through	ADP
dti-1294	25	16	drug	drug	NOUN
dti-1294	25	17	target	target	NOUN
dti-1294	25	18	insights	insight	NOUN
dti-1294	25	19	2006	2006	NUM
dti-1294	25	20	:	:	PUNCT
dti-1294	25	21	130	130	NUM
dti-1294	25	22	pan	pan	NOUN
dti-1294	25	23	et	et	PROPN
dti-1294	25	24	al	al	PROPN
dti-1294	25	25	the	the	DET
dti-1294	25	26	broken	broken	ADJ
dti-1294	25	27	hole	hole	NOUN
dti-1294	25	28	of	of	ADP
dti-1294	25	29	the	the	DET
dti-1294	25	30	tumor	tumor	NOUN
dti-1294	25	31	blood	blood	NOUN
dti-1294	25	32	vessels	vessel	NOUN
dti-1294	25	33	and	and	CCONJ
dti-1294	25	34	spread	spread	VERB
dti-1294	25	35	out	out	ADP
dti-1294	25	36	in	in	ADP
dti-1294	25	37	the	the	DET
dti-1294	25	38	tumor	tumor	NOUN
dti-1294	25	39	tissue	tissue	NOUN
dti-1294	25	40	,	,	PUNCT
dti-1294	25	41	but	but	CCONJ
dti-1294	25	42	so	so	ADV
dti-1294	25	43	far	far	ADV
dti-1294	25	44	a	a	DET
dti-1294	25	45	strong	strong	ADJ
dti-1294	25	46	or	or	CCONJ
dti-1294	25	47	direct	direct	ADJ
dti-1294	25	48	evidence	evidence	NOUN
dti-1294	25	49	about	about	ADP
dti-1294	25	50	this	this	DET
dti-1294	25	51	hypothesis	hypothesis	NOUN
dti-1294	25	52	is	be	AUX
dti-1294	25	53	still	still	ADV
dti-1294	25	54	not	not	PART
dti-1294	25	55	available	available	ADJ
dti-1294	25	56	.	.	PUNCT
dti-1294	26	1	the	the	DET
dti-1294	26	2	main	main	ADJ
dti-1294	26	3	obstacle	obstacle	NOUN
dti-1294	26	4	in	in	ADP
dti-1294	26	5	this	this	DET
dti-1294	26	6	part	part	NOUN
dti-1294	26	7	of	of	ADP
dti-1294	26	8	study	study	NOUN
dti-1294	26	9	is	be	AUX
dti-1294	26	10	that	that	SCONJ
dti-1294	26	11	the	the	DET
dti-1294	26	12	liposomal	liposomal	ADJ
dti-1294	26	13	particles	particle	NOUN
dti-1294	26	14	are	be	AUX
dti-1294	26	15	composed	compose	VERB
dti-1294	26	16	of	of	ADP
dti-1294	26	17	lipid	lipid	ADJ
dti-1294	26	18	membranes	membrane	NOUN
dti-1294	26	19	,	,	PUNCT
dti-1294	26	20	which	which	PRON
dti-1294	26	21	will	will	AUX
dti-1294	26	22	be	be	AUX
dti-1294	26	23	destroyed	destroy	VERB
dti-1294	26	24	immediately	immediately	ADV
dti-1294	26	25	when	when	SCONJ
dti-1294	26	26	the	the	DET
dti-1294	26	27	solid	solid	ADJ
dti-1294	26	28	tumor	tumor	NOUN
dti-1294	26	29	tissue	tissue	NOUN
dti-1294	26	30	were	be	AUX
dti-1294	26	31	treated	treat	VERB
dti-1294	26	32	in	in	ADP
dti-1294	26	33	organic	organic	ADJ
dti-1294	26	34	solvents	solvent	NOUN
dti-1294	26	35	during	during	ADP
dti-1294	26	36	the	the	DET
dti-1294	26	37	procedures	procedure	NOUN
dti-1294	26	38	of	of	ADP
dti-1294	26	39	histological	histological	ADJ
dti-1294	26	40	stains	stain	NOUN
dti-1294	26	41	.	.	PUNCT
dti-1294	27	1	because	because	SCONJ
dti-1294	27	2	of	of	ADP
dti-1294	27	3	this	this	DET
dti-1294	27	4	reason	reason	NOUN
dti-1294	27	5	we	we	PRON
dti-1294	27	6	have	have	AUX
dti-1294	27	7	tried	try	VERB
dti-1294	27	8	to	to	PART
dti-1294	27	9	use	use	VERB
dti-1294	27	10	rhodamine	rhodamine	ADJ
dti-1294	27	11	labeled	label	VERB
dti-1294	27	12	latex	latex	PROPN
dti-1294	27	13	microsphere	microsphere	NOUN
dti-1294	27	14	particles	particle	NOUN
dti-1294	27	15	with	with	ADP
dti-1294	27	16	the	the	DET
dti-1294	27	17	same	same	ADJ
dti-1294	27	18	size	size	NOUN
dti-1294	27	19	(	(	PUNCT
dti-1294	27	20	100	100	NUM
dti-1294	27	21	nm	nm	NOUN
dti-1294	27	22	in	in	ADP
dti-1294	27	23	diameter	diameter	NOUN
dti-1294	27	24	)	)	PUNCT
dti-1294	27	25	and	and	CCONJ
dti-1294	27	26	negative	negative	ADJ
dti-1294	27	27	electro	electro	ADJ
dti-1294	27	28	charge	charge	NOUN
dti-1294	27	29	to	to	PART
dti-1294	27	30	mimic	mimic	VERB
dti-1294	27	31	the	the	DET
dti-1294	27	32	behaving	behaving	NOUN
dti-1294	27	33	of	of	ADP
dti-1294	27	34	the	the	DET
dti-1294	27	35	liposomal	liposomal	ADJ
dti-1294	27	36	particles	particle	NOUN
dti-1294	27	37	(	(	PUNCT
dti-1294	27	38	pan	pan	PROPN
dti-1294	27	39	et	et	PROPN
dti-1294	27	40	al	al	PROPN
dti-1294	27	41	.	.	PROPN
dti-1294	27	42	2004	2004	NUM
dti-1294	27	43	)	)	PUNCT
dti-1294	27	44	.	.	PUNCT
dti-1294	28	1	the	the	DET
dti-1294	28	2	results	result	NOUN
dti-1294	28	3	were	be	AUX
dti-1294	28	4	very	very	ADV
dti-1294	28	5	good	good	ADJ
dti-1294	28	6	,	,	PUNCT
dti-1294	28	7	from	from	ADP
dti-1294	28	8	the	the	DET
dti-1294	28	9	fl	fl	NUM
dti-1294	28	10	uorescent	uorescent	ADJ
dti-1294	28	11	color	color	NOUN
dti-1294	28	12	,	,	PUNCT
dti-1294	28	13	we	we	PRON
dti-1294	28	14	can	can	AUX
dti-1294	28	15	see	see	VERB
dti-1294	28	16	the	the	DET
dti-1294	28	17	red	red	ADJ
dti-1294	28	18	color	color	NOUN
dti-1294	28	19	particles	particle	NOUN
dti-1294	28	20	leaking	leak	VERB
dti-1294	28	21	out	out	ADP
dti-1294	28	22	from	from	ADP
dti-1294	28	23	green	green	ADJ
dti-1294	28	24	color	color	NOUN
dti-1294	28	25	blood	blood	NOUN
dti-1294	28	26	vessels	vessel	NOUN
dti-1294	28	27	through	through	ADP
dti-1294	28	28	the	the	DET
dti-1294	28	29	broken	broken	ADJ
dti-1294	28	30	areas	area	NOUN
dti-1294	28	31	,	,	PUNCT
dti-1294	28	32	but	but	CCONJ
dti-1294	28	33	not	not	PART
dti-1294	28	34	from	from	ADP
dti-1294	28	35	everywhere	everywhere	ADV
dti-1294	28	36	or	or	CCONJ
dti-1294	28	37	passing	pass	VERB
dti-1294	28	38	through	through	ADP
dti-1294	28	39	the	the	DET
dti-1294	28	40	blood	blood	NOUN
dti-1294	28	41	vessel	vessel	NOUN
dti-1294	28	42	wall	wall	NOUN
dti-1294	28	43	.	.	PUNCT
dti-1294	29	1	however	however	ADV
dti-1294	29	2	,	,	PUNCT
dti-1294	29	3	the	the	DET
dti-1294	29	4	methods	method	NOUN
dti-1294	29	5	of	of	ADP
dti-1294	29	6	using	use	VERB
dti-1294	29	7	latex	latex	NOUN
dti-1294	29	8	microspheres	microsphere	NOUN
dti-1294	29	9	has	have	VERB
dti-1294	29	10	limitations	limitation	NOUN
dti-1294	29	11	,	,	PUNCT
dti-1294	29	12	fi	fi	NOUN
dti-1294	29	13	rst	rst	INTJ
dti-1294	29	14	they	they	PRON
dti-1294	29	15	are	be	AUX
dti-1294	29	16	rigid	rigid	ADJ
dti-1294	29	17	particles	particle	NOUN
dti-1294	29	18	,	,	PUNCT
dti-1294	29	19	possibly	possibly	ADV
dti-1294	29	20	still	still	ADV
dti-1294	29	21	not	not	PART
dti-1294	29	22	totally	totally	ADV
dti-1294	29	23	the	the	DET
dti-1294	29	24	same	same	ADJ
dti-1294	29	25	to	to	ADP
dti-1294	29	26	the	the	DET
dti-1294	29	27	real	real	ADJ
dti-1294	29	28	liposomal	liposomal	ADJ
dti-1294	29	29	particles	particle	NOUN
dti-1294	29	30	,	,	PUNCT
dti-1294	29	31	second	second	ADJ
dti-1294	29	32	,	,	PUNCT
dti-1294	29	33	they	they	PRON
dti-1294	29	34	will	will	AUX
dti-1294	29	35	not	not	PART
dti-1294	29	36	be	be	AUX
dti-1294	29	37	up	up	ADV
dti-1294	29	38	taken	take	VERB
dti-1294	29	39	up	up	ADP
dti-1294	29	40	by	by	ADP
dti-1294	29	41	the	the	DET
dti-1294	29	42	cell	cell	NOUN
dti-1294	29	43	and	and	CCONJ
dti-1294	29	44	kill	kill	VERB
dti-1294	29	45	the	the	DET
dti-1294	29	46	cancer	cancer	NOUN
dti-1294	29	47	cells	cell	NOUN
dti-1294	29	48	as	as	SCONJ
dti-1294	29	49	the	the	DET
dti-1294	29	50	liposomal	liposomal	ADJ
dti-1294	29	51	particles	particle	NOUN
dti-1294	29	52	probably	probably	ADV
dti-1294	29	53	will	will	AUX
dti-1294	29	54	do	do	VERB
dti-1294	29	55	.	.	PUNCT
dti-1294	30	1	these	these	DET
dti-1294	30	2	week	week	NOUN
dti-1294	30	3	points	point	NOUN
dti-1294	30	4	become	become	VERB
dti-1294	30	5	critical	critical	ADJ
dti-1294	30	6	,	,	PUNCT
dti-1294	30	7	when	when	SCONJ
dti-1294	30	8	we	we	PRON
dti-1294	30	9	want	want	VERB
dti-1294	30	10	to	to	PART
dti-1294	30	11	compare	compare	VERB
dti-1294	30	12	the	the	DET
dti-1294	30	13	different	different	ADJ
dti-1294	30	14	situations	situation	NOUN
dti-1294	30	15	between	between	ADP
dti-1294	30	16	the	the	DET
dti-1294	30	17	nontargeted	nontargete	VERB
dti-1294	30	18	and	and	CCONJ
dti-1294	30	19	the	the	DET
dti-1294	30	20	targeted	target	VERB
dti-1294	30	21	liposomal	liposomal	ADJ
dti-1294	30	22	particles	particle	NOUN
dti-1294	30	23	.	.	PUNCT
dti-1294	31	1	it	it	PRON
dti-1294	31	2	is	be	AUX
dti-1294	31	3	not	not	PART
dti-1294	31	4	impossible	impossible	ADJ
dti-1294	31	5	to	to	PART
dti-1294	31	6	label	label	VERB
dti-1294	31	7	the	the	DET
dti-1294	31	8	latex	latex	NOUN
dti-1294	31	9	microspheres	microsphere	NOUN
dti-1294	31	10	,	,	PUNCT
dti-1294	31	11	make	make	VERB
dti-1294	31	12	them	they	PRON
dti-1294	31	13	become	become	VERB
dti-1294	31	14	targeted	target	VERB
dti-1294	31	15	or	or	CCONJ
dti-1294	31	16	carry	carry	VERB
dti-1294	31	17	drugs	drug	NOUN
dti-1294	31	18	,	,	PUNCT
dti-1294	31	19	but	but	CCONJ
dti-1294	31	20	it	it	PRON
dti-1294	31	21	is	be	AUX
dti-1294	31	22	kind	kind	ADV
dti-1294	31	23	of	of	ADV
dti-1294	31	24	diffi	diffi	ADJ
dti-1294	31	25	cult	cult	NOUN
dti-1294	31	26	to	to	ADP
dti-1294	31	27	control	control	NOUN
dti-1294	31	28	,	,	PUNCT
dti-1294	31	29	anyway	anyway	ADV
dti-1294	31	30	,	,	PUNCT
dti-1294	31	31	it	it	PRON
dti-1294	31	32	will	will	AUX
dti-1294	31	33	be	be	AUX
dti-1294	31	34	another	another	DET
dti-1294	31	35	research	research	NOUN
dti-1294	31	36	,	,	PUNCT
dti-1294	31	37	no	no	ADV
dti-1294	31	38	longer	long	ADV
dti-1294	31	39	the	the	DET
dti-1294	31	40	problem	problem	NOUN
dti-1294	31	41	of	of	ADP
dti-1294	31	42	liposomal	liposomal	ADJ
dti-1294	31	43	drugs	drug	NOUN
dti-1294	31	44	we	we	PRON
dti-1294	31	45	want	want	VERB
dti-1294	31	46	to	to	PART
dti-1294	31	47	see	see	VERB
dti-1294	31	48	at	at	ADP
dti-1294	31	49	present	present	ADJ
dti-1294	31	50	time	time	NOUN
dti-1294	31	51	.	.	PUNCT
dti-1294	32	1	nevertheless	nevertheless	ADV
dti-1294	32	2	,	,	PUNCT
dti-1294	32	3	based	base	VERB
dti-1294	32	4	on	on	ADP
dti-1294	32	5	the	the	DET
dti-1294	32	6	experience	experience	NOUN
dti-1294	32	7	with	with	ADP
dti-1294	32	8	the	the	DET
dti-1294	32	9	use	use	NOUN
dti-1294	32	10	of	of	ADP
dti-1294	32	11	fl	fl	NUM
dti-1294	32	12	uorescent	uorescent	ADJ
dti-1294	32	13	latex	latex	PROPN
dti-1294	32	14	microspheres	microsphere	NOUN
dti-1294	32	15	,	,	PUNCT
dti-1294	32	16	we	we	PRON
dti-1294	32	17	realized	realize	VERB
dti-1294	32	18	if	if	SCONJ
dti-1294	32	19	we	we	PRON
dti-1294	32	20	omitted	omit	VERB
dti-1294	32	21	the	the	DET
dti-1294	32	22	acetone	acetone	NOUN
dti-1294	32	23	fi	fi	NOUN
dti-1294	32	24	xing	xing	PROPN
dti-1294	32	25	step	step	NOUN
dti-1294	32	26	,	,	PUNCT
dti-1294	32	27	instead	instead	ADV
dti-1294	32	28	,	,	PUNCT
dti-1294	32	29	dried	dry	VERB
dti-1294	32	30	the	the	DET
dti-1294	32	31	thin	thin	ADJ
dti-1294	32	32	cancer	cancer	NOUN
dti-1294	32	33	tissue	tissue	NOUN
dti-1294	32	34	under	under	ADP
dti-1294	32	35	an	an	DET
dti-1294	32	36	air	air	NOUN
dti-1294	33	1	fl	fl	INTJ
dti-1294	33	2	ow	ow	INTJ
dti-1294	33	3	immediately	immediately	ADV
dti-1294	33	4	after	after	SCONJ
dti-1294	33	5	the	the	DET
dti-1294	33	6	cryosections	cryosection	NOUN
dti-1294	33	7	have	have	AUX
dti-1294	33	8	been	be	AUX
dti-1294	33	9	mounted	mount	VERB
dti-1294	33	10	on	on	ADP
dti-1294	33	11	the	the	DET
dti-1294	33	12	glass	glass	NOUN
dti-1294	33	13	slices	slice	NOUN
dti-1294	33	14	,	,	PUNCT
dti-1294	33	15	then	then	ADV
dti-1294	33	16	stained	stain	VERB
dti-1294	33	17	the	the	DET
dti-1294	33	18	tumor	tumor	NOUN
dti-1294	33	19	sections	section	NOUN
dti-1294	33	20	with	with	ADP
dti-1294	33	21	antibody	antibody	NOUN
dti-1294	33	22	or	or	CCONJ
dti-1294	33	23	chemical	chemical	NOUN
dti-1294	33	24	reagent	reagent	NOUN
dti-1294	33	25	in	in	ADP
dti-1294	33	26	water	water	NOUN
dti-1294	33	27	solutions	solution	NOUN
dti-1294	33	28	,	,	PUNCT
dti-1294	33	29	we	we	PRON
dti-1294	33	30	may	may	AUX
dti-1294	33	31	be	be	AUX
dti-1294	33	32	able	able	ADJ
dti-1294	33	33	to	to	PART
dti-1294	33	34	avoided	avoided	VERB
dti-1294	33	35	the	the	DET
dti-1294	33	36	damage	damage	NOUN
dti-1294	33	37	of	of	ADP
dti-1294	33	38	the	the	DET
dti-1294	33	39	liposomal	liposomal	ADJ
dti-1294	33	40	particles	particle	NOUN
dti-1294	33	41	,	,	PUNCT
dti-1294	33	42	and	and	CCONJ
dti-1294	33	43	see	see	VERB
dti-1294	33	44	the	the	DET
dti-1294	33	45	liposome	liposome	NOUN
dti-1294	33	46	particles	particle	NOUN
dti-1294	33	47	,	,	PUNCT
dti-1294	33	48	if	if	SCONJ
dti-1294	33	49	the	the	DET
dti-1294	33	50	liposome	liposome	NOUN
dti-1294	33	51	particles	particle	NOUN
dti-1294	33	52	carried	carry	VERB
dti-1294	33	53	a	a	DET
dti-1294	33	54	red	red	ADJ
dti-1294	33	55	color	color	NOUN
dti-1294	33	56	fl	fl	PROPN
dti-1294	33	57	uorescence	uorescence	NOUN
dti-1294	33	58	.	.	PUNCT
dti-1294	34	1	thus	thus	ADV
dti-1294	34	2	,	,	PUNCT
dti-1294	34	3	in	in	ADP
dti-1294	34	4	this	this	DET
dti-1294	34	5	study	study	NOUN
dti-1294	34	6	,	,	PUNCT
dti-1294	34	7	we	we	PRON
dti-1294	34	8	are	be	AUX
dti-1294	34	9	using	use	VERB
dti-1294	34	10	the	the	DET
dti-1294	34	11	real	real	ADJ
dti-1294	34	12	pegyl	pegyl	ADJ
dti-1294	34	13	-	-	PUNCT
dti-1294	34	14	dspc	dspc	NOUN
dti-1294	34	15	liposomal	liposomal	NOUN
dti-1294	34	16	doxorubicin	doxorubicin	PROPN
dti-1294	34	17	as	as	ADP
dti-1294	34	18	a	a	DET
dti-1294	34	19	tool	tool	NOUN
dti-1294	34	20	to	to	PART
dti-1294	34	21	run	run	VERB
dti-1294	34	22	the	the	DET
dti-1294	34	23	observation	observation	NOUN
dti-1294	34	24	.	.	PUNCT
dti-1294	35	1	the	the	DET
dti-1294	35	2	advantage	advantage	NOUN
dti-1294	35	3	of	of	ADP
dti-1294	35	4	this	this	DET
dti-1294	35	5	liposome	liposome	NOUN
dti-1294	35	6	is	be	AUX
dti-1294	35	7	fi	fi	NOUN
dti-1294	35	8	rst	rst	INTJ
dti-1294	35	9	we	we	PRON
dti-1294	35	10	can	can	AUX
dti-1294	35	11	locate	locate	VERB
dti-1294	35	12	the	the	DET
dti-1294	35	13	liposome	liposome	NOUN
dti-1294	35	14	by	by	ADP
dti-1294	35	15	the	the	DET
dti-1294	35	16	red	red	ADJ
dti-1294	35	17	color	color	NOUN
dti-1294	35	18	fl	fl	PROPN
dti-1294	35	19	uorescence	uorescence	NOUN
dti-1294	35	20	of	of	ADP
dti-1294	35	21	drug	drug	NOUN
dti-1294	35	22	doxorubicine	doxorubicine	NOUN
dti-1294	35	23	with	with	ADP
dti-1294	35	24	the	the	DET
dti-1294	35	25	same	same	ADJ
dti-1294	35	26	method	method	NOUN
dti-1294	35	27	of	of	ADP
dti-1294	35	28	fl	fl	NUM
dti-1294	35	29	uorescent	uorescent	ADJ
dti-1294	35	30	stains	stain	NOUN
dti-1294	35	31	as	as	SCONJ
dti-1294	35	32	we	we	PRON
dti-1294	35	33	have	have	AUX
dti-1294	35	34	used	use	VERB
dti-1294	35	35	in	in	ADP
dti-1294	35	36	the	the	DET
dti-1294	35	37	fl	fl	PROPN
dti-1294	35	38	uorescent	uorescent	ADJ
dti-1294	35	39	latex	latex	NOUN
dti-1294	35	40	microspheres	microsphere	NOUN
dti-1294	35	41	;	;	PUNCT
dti-1294	35	42	and	and	CCONJ
dti-1294	35	43	the	the	DET
dti-1294	35	44	second	second	ADJ
dti-1294	35	45	,	,	PUNCT
dti-1294	35	46	these	these	DET
dti-1294	35	47	folic	folic	ADJ
dti-1294	35	48	acid	acid	NOUN
dti-1294	35	49	targeted	target	VERB
dti-1294	35	50	and	and	CCONJ
dti-1294	35	51	non	non	ADJ
dti-1294	35	52	-	-	ADJ
dti-1294	35	53	targeted	targeted	ADJ
dti-1294	35	54	liposomes	liposome	NOUN
dti-1294	35	55	have	have	AUX
dti-1294	35	56	been	be	AUX
dti-1294	35	57	used	use	VERB
dti-1294	35	58	in	in	ADP
dti-1294	35	59	set	set	NOUN
dti-1294	35	60	of	of	ADP
dti-1294	35	61	liposome	liposome	NOUN
dti-1294	35	62	studies	study	NOUN
dti-1294	35	63	in	in	ADP
dti-1294	35	64	our	our	PRON
dti-1294	35	65	study	study	NOUN
dti-1294	35	66	in	in	ADP
dti-1294	35	67	the	the	DET
dti-1294	35	68	past	past	NOUN
dti-1294	35	69	.	.	PUNCT
dti-1294	36	1	in	in	ADP
dti-1294	36	2	this	this	DET
dti-1294	36	3	case	case	NOUN
dti-1294	36	4	,	,	PUNCT
dti-1294	36	5	with	with	ADP
dti-1294	36	6	the	the	DET
dti-1294	36	7	limited	limited	ADJ
dti-1294	36	8	changes	change	NOUN
dti-1294	36	9	,	,	PUNCT
dti-1294	36	10	more	more	ADJ
dti-1294	36	11	results	result	NOUN
dti-1294	36	12	can	can	AUX
dti-1294	36	13	be	be	AUX
dti-1294	36	14	used	use	VERB
dti-1294	36	15	in	in	ADP
dti-1294	36	16	comparasion	comparasion	NOUN
dti-1294	36	17	,	,	PUNCT
dti-1294	36	18	with	with	SCONJ
dti-1294	36	19	that	that	SCONJ
dti-1294	36	20	we	we	PRON
dti-1294	36	21	may	may	AUX
dti-1294	36	22	be	be	AUX
dti-1294	36	23	able	able	ADJ
dti-1294	36	24	to	to	PART
dti-1294	36	25	obtain	obtain	VERB
dti-1294	36	26	some	some	DET
dti-1294	36	27	better	well	ADJ
dti-1294	36	28	ideas	idea	NOUN
dti-1294	36	29	about	about	ADP
dti-1294	36	30	it	it	PRON
dti-1294	36	31	.	.	PUNCT
dti-1294	37	1	meanwhile	meanwhile	ADV
dti-1294	37	2	,	,	PUNCT
dti-1294	37	3	in	in	ADP
dti-1294	37	4	another	another	DET
dti-1294	37	5	experiment	experiment	NOUN
dti-1294	37	6	,	,	PUNCT
dti-1294	37	7	we	we	PRON
dti-1294	37	8	also	also	ADV
dti-1294	37	9	observed	observe	VERB
dti-1294	37	10	the	the	DET
dti-1294	37	11	fortune	fortune	NOUN
dti-1294	37	12	of	of	ADP
dti-1294	37	13	these	these	DET
dti-1294	37	14	liposomal	liposomal	ADJ
dti-1294	37	15	particles	particle	NOUN
dti-1294	37	16	after	after	SCONJ
dti-1294	37	17	they	they	PRON
dti-1294	37	18	got	get	VERB
dti-1294	37	19	into	into	ADP
dti-1294	37	20	the	the	DET
dti-1294	37	21	solid	solid	ADJ
dti-1294	37	22	tumor	tumor	NOUN
dti-1294	37	23	tissue	tissue	NOUN
dti-1294	37	24	,	,	PUNCT
dti-1294	37	25	and	and	CCONJ
dti-1294	37	26	compared	compare	VERB
dti-1294	37	27	the	the	DET
dti-1294	37	28	anticancer	anticancer	NOUN
dti-1294	37	29	effectiveness	effectiveness	NOUN
dti-1294	37	30	of	of	ADP
dti-1294	37	31	these	these	DET
dti-1294	37	32	liposomal	liposomal	ADJ
dti-1294	37	33	doxorubicin	doxorubicin	PROPN
dti-1294	37	34	in	in	ADP
dti-1294	37	35	mice	mouse	NOUN
dti-1294	37	36	.	.	PUNCT
dti-1294	38	1	the	the	DET
dti-1294	38	2	results	result	NOUN
dti-1294	38	3	were	be	AUX
dti-1294	38	4	surprisely	surprisely	ADV
dti-1294	38	5	different	different	ADJ
dti-1294	38	6	to	to	ADP
dti-1294	38	7	what	what	PRON
dti-1294	38	8	we	we	PRON
dti-1294	38	9	used	use	VERB
dti-1294	38	10	to	to	PART
dti-1294	38	11	believe	believe	VERB
dti-1294	38	12	,	,	PUNCT
dti-1294	38	13	the	the	DET
dti-1294	38	14	better	well	ADJ
dti-1294	38	15	anticancer	anticancer	NOUN
dti-1294	38	16	effectiveness	effectiveness	NOUN
dti-1294	38	17	was	be	AUX
dti-1294	38	18	not	not	PART
dti-1294	38	19	because	because	SCONJ
dti-1294	38	20	of	of	ADP
dti-1294	38	21	more	more	ADV
dti-1294	38	22	folic	folic	ADJ
dti-1294	38	23	acid	acid	NOUN
dti-1294	38	24	targeted	target	VERB
dti-1294	38	25	particles	particle	NOUN
dti-1294	38	26	getting	get	VERB
dti-1294	38	27	into	into	ADP
dti-1294	38	28	tumor	tumor	NOUN
dti-1294	38	29	tissue	tissue	NOUN
dti-1294	38	30	,	,	PUNCT
dti-1294	38	31	the	the	DET
dti-1294	38	32	better	well	ADJ
dti-1294	38	33	anticancer	anticancer	NOUN
dti-1294	38	34	effectiveness	effectiveness	NOUN
dti-1294	38	35	came	come	VERB
dti-1294	38	36	from	from	ADP
dti-1294	38	37	the	the	DET
dti-1294	38	38	non	non	ADJ
dti-1294	38	39	-	-	ADJ
dti-1294	38	40	targeted	targeted	ADJ
dti-1294	38	41	liposomal	liposomal	ADJ
dti-1294	38	42	particles	particle	NOUN
dti-1294	38	43	kept	keep	VERB
dti-1294	38	44	in	in	ADP
dti-1294	38	45	the	the	DET
dti-1294	38	46	tumor	tumor	NOUN
dti-1294	38	47	tissue	tissue	NOUN
dti-1294	38	48	for	for	ADP
dti-1294	38	49	long	long	ADJ
dti-1294	38	50	time	time	NOUN
dti-1294	38	51	with	with	ADP
dti-1294	38	52	no	no	DET
dti-1294	38	53	change	change	NOUN
dti-1294	38	54	,	,	PUNCT
dti-1294	38	55	kept	keep	VERB
dti-1294	38	56	the	the	DET
dti-1294	38	57	drug	drug	NOUN
dti-1294	38	58	doxorubicin	doxorubicin	PROPN
dti-1294	38	59	inside	inside	ADP
dti-1294	38	60	the	the	DET
dti-1294	38	61	lipid	lipid	NOUN
dti-1294	38	62	membrane	membrane	NOUN
dti-1294	38	63	and	and	CCONJ
dti-1294	38	64	no	no	DET
dti-1294	38	65	chance	chance	NOUN
dti-1294	38	66	to	to	PART
dti-1294	38	67	meet	meet	VERB
dti-1294	38	68	the	the	DET
dti-1294	38	69	cancer	cancer	NOUN
dti-1294	38	70	cells	cell	NOUN
dti-1294	38	71	.	.	PUNCT
dti-1294	39	1	those	those	DET
dti-1294	39	2	results	result	NOUN
dti-1294	39	3	will	will	AUX
dti-1294	39	4	be	be	AUX
dti-1294	39	5	reported	report	VERB
dti-1294	39	6	in	in	ADP
dti-1294	39	7	another	another	DET
dti-1294	39	8	paper	paper	NOUN
dti-1294	39	9	.	.	PUNCT
dti-1294	40	1	the	the	DET
dti-1294	40	2	abstract	abstract	NOUN
dti-1294	40	3	of	of	ADP
dti-1294	40	4	these	these	DET
dti-1294	40	5	results	result	NOUN
dti-1294	40	6	have	have	AUX
dti-1294	40	7	been	be	AUX
dti-1294	40	8	present	present	ADJ
dti-1294	40	9	in	in	ADP
dti-1294	40	10	the	the	DET
dti-1294	40	11	meeting	meeting	NOUN
dti-1294	40	12	os	os	PROPN
dti-1294	40	13	aacs	aacs	PROPN
dti-1294	40	14	(	(	PUNCT
dti-1294	40	15	pan	pan	PROPN
dti-1294	40	16	et	et	PROPN
dti-1294	40	17	al	al	PROPN
dti-1294	40	18	.	.	PROPN
dti-1294	40	19	2005	2005	NUM
dti-1294	40	20	)	)	PUNCT
dti-1294	40	21	.	.	PUNCT
dti-1294	41	1	we	we	PRON
dti-1294	41	2	hope	hope	VERB
dti-1294	41	3	based	base	VERB
dti-1294	41	4	on	on	ADP
dti-1294	41	5	these	these	DET
dti-1294	41	6	new	new	ADJ
dti-1294	41	7	information	information	NOUN
dti-1294	41	8	we	we	PRON
dti-1294	41	9	may	may	AUX
dti-1294	41	10	be	be	AUX
dti-1294	41	11	able	able	ADJ
dti-1294	41	12	to	to	PART
dti-1294	41	13	fi	fi	VERB
dti-1294	41	14	nd	nd	NOUN
dti-1294	41	15	out	out	ADP
dti-1294	41	16	what	what	PRON
dti-1294	41	17	should	should	AUX
dti-1294	41	18	we	we	PRON
dti-1294	41	19	do	do	VERB
dti-1294	41	20	to	to	PART
dti-1294	41	21	improve	improve	VERB
dti-1294	41	22	the	the	DET
dti-1294	41	23	effectiveness	effectiveness	NOUN
dti-1294	41	24	of	of	ADP
dti-1294	41	25	the	the	DET
dti-1294	41	26	liposomal	liposomal	ADJ
dti-1294	41	27	drug	drug	NOUN
dti-1294	41	28	treatment	treatment	NOUN
dti-1294	41	29	in	in	ADP
dti-1294	41	30	vivo	vivo	NOUN
dti-1294	41	31	.	.	PUNCT
dti-1294	42	1	materials	material	NOUN
dti-1294	42	2	and	and	CCONJ
dti-1294	42	3	methods	method	NOUN
dti-1294	42	4	reagents	reagent	NOUN
dti-1294	42	5	folic	folic	ADJ
dti-1294	42	6	acid	acid	NOUN
dti-1294	42	7	free	free	ADJ
dti-1294	42	8	rpmi	rpmi	NOUN
dti-1294	42	9	1640	1640	NUM
dti-1294	42	10	and	and	CCONJ
dti-1294	42	11	fetal	fetal	ADJ
dti-1294	42	12	calf	calf	NOUN
dti-1294	42	13	serum	serum	NOUN
dti-1294	42	14	were	be	AUX
dti-1294	42	15	purchased	purchase	VERB
dti-1294	42	16	from	from	ADP
dti-1294	42	17	gibco	gibco	NOUN
dti-1294	42	18	(	(	PUNCT
dti-1294	42	19	grand	grand	ADJ
dti-1294	42	20	island	island	NOUN
dti-1294	42	21	,	,	PUNCT
dti-1294	42	22	ny	ny	PROPN
dti-1294	42	23	,	,	PUNCT
dti-1294	42	24	u.s.a	u.s.a	PROPN
dti-1294	42	25	.	.	PUNCT
dti-1294	42	26	)	)	PUNCT
dti-1294	42	27	.	.	PUNCT
dti-1294	43	1	dspc	dspc	NOUN
dti-1294	43	2	and	and	CCONJ
dti-1294	43	3	peg2000	peg2000	ADJ
dti-1294	43	4	-	-	PUNCT
dti-1294	43	5	dspc	dspc	NOUN
dti-1294	43	6	were	be	AUX
dti-1294	43	7	purchased	purchase	VERB
dti-1294	43	8	from	from	ADP
dti-1294	43	9	avanti	avanti	PROPN
dti-1294	43	10	polar	polar	PROPN
dti-1294	43	11	lipids	lipids	PROPN
dti-1294	43	12	,	,	PUNCT
dti-1294	43	13	inc	inc	PROPN
dti-1294	43	14	.	.	PROPN
dti-1294	43	15	folate	folate	NOUN
dti-1294	43	16	-	-	PUNCT
dti-1294	43	17	ped3400dspc	ped3400dspc	PROPN
dti-1294	43	18	was	be	AUX
dti-1294	43	19	obtained	obtain	VERB
dti-1294	43	20	from	from	ADP
dti-1294	43	21	the	the	DET
dti-1294	43	22	nih	nih	PROPN
dti-1294	43	23	.	.	PUNCT
dti-1294	44	1	the	the	DET
dti-1294	44	2	other	other	ADJ
dti-1294	44	3	reagents	reagent	NOUN
dti-1294	44	4	such	such	ADJ
dti-1294	44	5	as	as	ADP
dti-1294	44	6	cholesterol	cholesterol	NOUN
dti-1294	44	7	,	,	PUNCT
dti-1294	44	8	doxorubicin	doxorubicin	PROPN
dti-1294	44	9	and	and	CCONJ
dti-1294	44	10	sepharose	sepharose	VERB
dti-1294	44	11	cl-4b	cl-4b	PROPN
dti-1294	44	12	chromatography	chromatography	NOUN
dti-1294	44	13	resin	resin	NOUN
dti-1294	44	14	were	be	AUX
dti-1294	44	15	obtained	obtain	VERB
dti-1294	44	16	from	from	ADP
dti-1294	44	17	sigma	sigma	PROPN
dti-1294	44	18	chemical	chemical	PROPN
dti-1294	44	19	co	co	PROPN
dti-1294	44	20	(	(	PUNCT
dti-1294	44	21	st	st	PROPN
dti-1294	44	22	.	.	PROPN
dti-1294	44	23	louis	louis	PROPN
dti-1294	44	24	,	,	PUNCT
dti-1294	44	25	missouri	missouri	PROPN
dti-1294	44	26	)	)	PUNCT
dti-1294	44	27	.	.	PUNCT
dti-1294	45	1	rat	rat	NOUN
dti-1294	45	2	anti	anti	ADJ
dti-1294	45	3	-	-	ADJ
dti-1294	45	4	mouse	mouse	ADJ
dti-1294	45	5	cd31	cd31	PROPN
dti-1294	45	6	antibody	antibody	NOUN
dti-1294	45	7	was	be	AUX
dti-1294	45	8	obtained	obtain	VERB
dti-1294	45	9	from	from	ADP
dti-1294	45	10	bd	bd	PROPN
dti-1294	45	11	pharmingen	pharmingen	PROPN
dti-1294	45	12	(	(	PUNCT
dti-1294	45	13	san	san	PROPN
dti-1294	45	14	diego	diego	PROPN
dti-1294	45	15	,	,	PUNCT
dti-1294	45	16	ca	ca	PROPN
dti-1294	45	17	,	,	PUNCT
dti-1294	45	18	u.s.a	u.s.a	PROPN
dti-1294	45	19	.	.	PROPN
dti-1294	45	20	,	,	PUNCT
dti-1294	45	21	catalog	catalog	NOUN
dti-1294	45	22	number	number	NOUN
dti-1294	45	23	550274	550274	NUM
dti-1294	45	24	)	)	PUNCT
dti-1294	45	25	.	.	PUNCT
dti-1294	46	1	the	the	DET
dti-1294	46	2	biotinylated	biotinylate	VERB
dti-1294	46	3	rabbit	rabbit	NOUN
dti-1294	46	4	anti	anti	ADJ
dti-1294	46	5	-	-	ADJ
dti-1294	46	6	rat	rat	ADJ
dti-1294	46	7	,	,	PUNCT
dti-1294	46	8	mouse	mouse	NOUN
dti-1294	46	9	absorbed	absorb	VERB
dti-1294	46	10	antibody	antibody	NOUN
dti-1294	46	11	was	be	AUX
dti-1294	46	12	purchased	purchase	VERB
dti-1294	46	13	from	from	ADP
dti-1294	46	14	vector	vector	PROPN
dti-1294	46	15	,	,	PUNCT
dti-1294	46	16	inc	inc	PROPN
dti-1294	46	17	.	.	PROPN
dti-1294	46	18	(	(	PUNCT
dti-1294	46	19	burlingame	burlingame	PROPN
dti-1294	46	20	,	,	PUNCT
dti-1294	46	21	ca	ca	PROPN
dti-1294	46	22	,	,	PUNCT
dti-1294	46	23	u.s.a	u.s.a	PROPN
dti-1294	46	24	.	.	PROPN
dti-1294	46	25	,	,	PUNCT
dti-1294	46	26	catalog	catalog	NOUN
dti-1294	46	27	number	number	NOUN
dti-1294	46	28	ba-4001	ba-4001	NOUN
dti-1294	46	29	)	)	PUNCT
dti-1294	46	30	,	,	PUNCT
dti-1294	46	31	and	and	CCONJ
dti-1294	46	32	the	the	DET
dti-1294	46	33	fitcstreptavidin	fitcstreptavidin	NOUN
dti-1294	46	34	was	be	AUX
dti-1294	46	35	obtained	obtain	VERB
dti-1294	46	36	from	from	ADP
dti-1294	46	37	dako	dako	PROPN
dti-1294	46	38	inc	inc	PROPN
dti-1294	46	39	.	.	PROPN
dti-1294	46	40	(	(	PUNCT
dti-1294	46	41	carpinteria	carpinteria	PROPN
dti-1294	46	42	,	,	PUNCT
dti-1294	46	43	ca	ca	PROPN
dti-1294	46	44	,	,	PUNCT
dti-1294	46	45	u.s.a	u.s.a	PROPN
dti-1294	46	46	.	.	PROPN
dti-1294	46	47	,	,	PUNCT
dti-1294	46	48	catalog	catalog	NOUN
dti-1294	46	49	number	number	NOUN
dti-1294	46	50	f0422	f0422	NUM
dti-1294	46	51	)	)	PUNCT
dti-1294	46	52	.	.	PUNCT
dti-1294	47	1	the	the	DET
dti-1294	47	2	nuclei	nuclei	PROPN
dti-1294	47	3	stain	stain	VERB
dti-1294	47	4	fl	fl	PRON
dti-1294	47	5	uorescent	uorescent	ADJ
dti-1294	47	6	dye	dye	NOUN
dti-1294	47	7	dapi	dapi	ADJ
dti-1294	48	1	(	(	PUNCT
dti-1294	48	2	4	4	NUM
dti-1294	48	3	’	'	PUNCT
dti-1294	48	4	,	,	PUNCT
dti-1294	48	5	6diamidino-2	6diamidino-2	NUM
dti-1294	48	6	-	-	PUNCT
dti-1294	48	7	phenylindole	phenylindole	NOUN
dti-1294	48	8	)	)	PUNCT
dti-1294	48	9	containing	contain	VERB
dti-1294	48	10	mount	mount	PROPN
dti-1294	48	11	medium	medium	NOUN
dti-1294	48	12	was	be	AUX
dti-1294	48	13	a	a	DET
dti-1294	48	14	gift	gift	NOUN
dti-1294	48	15	from	from	ADP
dti-1294	48	16	dako	dako	PROPN
dti-1294	48	17	inc	inc	PROPN
dti-1294	48	18	.	.	PUNCT
dti-1294	49	1	the	the	DET
dti-1294	49	2	tissue	tissue	NOUN
dti-1294	49	3	-	-	PUNCT
dti-1294	49	4	tek	tek	NOUN
dti-1294	49	5	o.c.t	o.c.t	PROPN
dti-1294	49	6	.	.	PUNCT
dti-1294	49	7	compound	compound	PROPN
dti-1294	49	8	was	be	AUX
dti-1294	49	9	obtained	obtain	VERB
dti-1294	49	10	from	from	ADP
dti-1294	49	11	sakura	sakura	PROPN
dti-1294	49	12	finetek	finetek	PROPN
dti-1294	49	13	usa	usa	PROPN
dti-1294	49	14	inc	inc	PROPN
dti-1294	49	15	.	.	PROPN
dti-1294	49	16	(	(	PUNCT
dti-1294	49	17	torrance	torrance	NOUN
dti-1294	49	18	,	,	PUNCT
dti-1294	49	19	ca	ca	NOUN
dti-1294	49	20	,	,	PUNCT
dti-1294	49	21	u.s.a	u.s.a	PROPN
dti-1294	49	22	.	.	PUNCT
dti-1294	49	23	)	)	PUNCT
dti-1294	49	24	.	.	PUNCT
dti-1294	50	1	pegyl	pegyl	ADJ
dti-1294	50	2	-	-	PUNCT
dti-1294	50	3	dspc	dspc	NOUN
dti-1294	50	4	liposomal	liposomal	NOUN
dti-1294	50	5	doxorubicin	doxorubicin	PROPN
dti-1294	50	6	preparation	preparation	NOUN
dti-1294	50	7	dspc	dspc	PROPN
dti-1294	50	8	/	/	SYM
dti-1294	50	9	cholesterol	cholesterol	NOUN
dti-1294	50	10	/	/	SYM
dti-1294	50	11	peg	peg	NOUN
dti-1294	50	12	-	-	PUNCT
dti-1294	50	13	dspe	dspe	NOUN
dti-1294	50	14	(	(	PUNCT
dti-1294	50	15	65:31:4	65:31:4	NUM
dti-1294	50	16	,	,	PUNCT
dti-1294	50	17	mole/	mole/	ADJ
dti-1294	50	18	mole	mole	NOUN
dti-1294	50	19	)	)	PUNCT
dti-1294	50	20	non	non	ADJ
dti-1294	50	21	-	-	ADJ
dti-1294	50	22	targeting	targeting	ADJ
dti-1294	50	23	liposome	liposome	NOUN
dti-1294	50	24	and	and	CCONJ
dti-1294	50	25	dspc	dspc	NOUN
dti-1294	50	26	/	/	SYM
dti-1294	50	27	cholesdrug	cholesdrug	NOUN
dti-1294	50	28	target	target	NOUN
dti-1294	50	29	insights	insight	NOUN
dti-1294	50	30	2006	2006	NUM
dti-1294	50	31	:	:	PUNCT
dti-1294	50	32	1	1	NUM
dti-1294	50	33	31	31	NUM
dti-1294	50	34	observation	observation	NOUN
dti-1294	50	35	of	of	ADP
dti-1294	50	36	liposomal	liposomal	ADJ
dti-1294	50	37	drug	drug	NOUN
dti-1294	50	38	particles	particle	NOUN
dti-1294	50	39	penetrating	penetrate	VERB
dti-1294	50	40	into	into	ADP
dti-1294	50	41	solid	solid	ADJ
dti-1294	50	42	tumor	tumor	NOUN
dti-1294	50	43	tissue	tissue	NOUN
dti-1294	50	44	.	.	PUNCT
dti-1294	51	1	terol	terol	NOUN
dti-1294	51	2	/	/	SYM
dti-1294	51	3	peg2000	peg2000	NOUN
dti-1294	51	4	-	-	PUNCT
dti-1294	51	5	dspe	dspe	NOUN
dti-1294	51	6	/	/	SYM
dti-1294	51	7	folate	folate	NOUN
dti-1294	51	8	-	-	PUNCT
dti-1294	51	9	peg3400	peg3400	NOUN
dti-1294	51	10	-	-	PUNCT
dti-1294	51	11	dspe	dspe	NOUN
dti-1294	51	12	(	(	PUNCT
dti-1294	51	13	60:31:3.5:0.5	60:31:3.5:0.5	NUM
dti-1294	51	14	mole	mole	NOUN
dti-1294	51	15	/	/	SYM
dti-1294	51	16	mole	mole	NOUN
dti-1294	51	17	)	)	PUNCT
dti-1294	51	18	folate	folate	NOUN
dti-1294	51	19	targeted	target	VERB
dti-1294	51	20	liposomes	liposome	NOUN
dti-1294	51	21	were	be	AUX
dti-1294	51	22	prepared	prepare	VERB
dti-1294	51	23	by	by	ADP
dti-1294	51	24	the	the	DET
dti-1294	51	25	procedure	procedure	NOUN
dti-1294	51	26	we	we	PRON
dti-1294	51	27	used	use	VERB
dti-1294	51	28	in	in	ADP
dti-1294	51	29	previous	previous	ADJ
dti-1294	51	30	studies	study	NOUN
dti-1294	51	31	(	(	PUNCT
dti-1294	51	32	pan	pan	PROPN
dti-1294	51	33	et	et	PROPN
dti-1294	51	34	al	al	PROPN
dti-1294	51	35	.	.	PROPN
dti-1294	51	36	2003	2003	NUM
dti-1294	51	37	;	;	PUNCT
dti-1294	51	38	pan	pan	PROPN
dti-1294	51	39	et	et	PROPN
dti-1294	51	40	al	al	PROPN
dti-1294	51	41	.	.	PROPN
dti-1294	51	42	2002	2002	NUM
dti-1294	51	43	)	)	PUNCT
dti-1294	51	44	.	.	PUNCT
dti-1294	52	1	briefl	briefl	PROPN
dti-1294	52	2	y	y	PROPN
dti-1294	52	3	,	,	PUNCT
dti-1294	52	4	mixed	mix	VERB
dti-1294	52	5	the	the	DET
dti-1294	52	6	lipid	lipid	NOUN
dti-1294	52	7	composition	composition	NOUN
dti-1294	52	8	in	in	ADP
dti-1294	52	9	chloroform	chloroform	NOUN
dti-1294	52	10	solution	solution	NOUN
dti-1294	52	11	in	in	ADP
dti-1294	52	12	a	a	DET
dti-1294	52	13	round	round	ADJ
dti-1294	52	14	bottom	bottom	NOUN
dti-1294	52	15	fl	fl	NOUN
dti-1294	52	16	ask	ask	NOUN
dti-1294	52	17	,	,	PUNCT
dti-1294	52	18	totally	totally	ADV
dti-1294	52	19	weight	weight	NOUN
dti-1294	52	20	of	of	ADP
dti-1294	52	21	the	the	DET
dti-1294	52	22	lipid	lipid	NOUN
dti-1294	52	23	mixture	mixture	NOUN
dti-1294	52	24	was	be	AUX
dti-1294	52	25	30	30	NUM
dti-1294	52	26	mg	mg	NUM
dti-1294	52	27	.	.	PUNCT
dti-1294	53	1	then	then	ADV
dti-1294	53	2	this	this	DET
dti-1294	53	3	mixture	mixture	NOUN
dti-1294	53	4	solution	solution	NOUN
dti-1294	53	5	was	be	AUX
dti-1294	53	6	dried	dry	VERB
dti-1294	53	7	under	under	ADP
dti-1294	53	8	nitrogen	nitrogen	NOUN
dti-1294	53	9	.	.	PUNCT
dti-1294	54	1	the	the	DET
dti-1294	54	2	residue	residue	NOUN
dti-1294	54	3	was	be	AUX
dti-1294	54	4	desiccated	desiccate	VERB
dti-1294	54	5	under	under	ADP
dti-1294	54	6	vacuum	vacuum	NOUN
dti-1294	54	7	for	for	ADP
dti-1294	54	8	two	two	NUM
dti-1294	54	9	hours	hour	NOUN
dti-1294	54	10	,	,	PUNCT
dti-1294	54	11	and	and	CCONJ
dti-1294	54	12	re	re	VERB
dti-1294	54	13	-	-	NOUN
dti-1294	54	14	hydrated	hydrated	ADJ
dti-1294	54	15	in	in	ADP
dti-1294	54	16	5	5	NUM
dti-1294	54	17	ml	ml	NOUN
dti-1294	54	18	ph	ph	ADJ
dti-1294	54	19	4.0	4.0	NUM
dti-1294	54	20	,	,	PUNCT
dti-1294	54	21	400	400	NUM
dti-1294	54	22	mm	mm	NOUN
dti-1294	54	23	sodium	sodium	NOUN
dti-1294	54	24	citrate	citrate	NOUN
dti-1294	54	25	solution	solution	NOUN
dti-1294	54	26	,	,	PUNCT
dti-1294	54	27	treated	treat	VERB
dti-1294	54	28	with	with	ADP
dti-1294	54	29	ultrasonic	ultrasonic	ADJ
dti-1294	54	30	and	and	CCONJ
dti-1294	54	31	vortex	vortex	NOUN
dti-1294	54	32	,	,	PUNCT
dti-1294	54	33	freezing	freeze	VERB
dti-1294	54	34	and	and	CCONJ
dti-1294	54	35	thawing	thaw	VERB
dti-1294	54	36	alternately	alternately	ADV
dti-1294	54	37	.	.	PUNCT
dti-1294	55	1	the	the	DET
dti-1294	55	2	production	production	NOUN
dti-1294	55	3	was	be	AUX
dti-1294	55	4	then	then	ADV
dti-1294	55	5	passed	pass	VERB
dti-1294	55	6	through	through	ADP
dti-1294	55	7	a	a	DET
dti-1294	55	8	100	100	NUM
dti-1294	55	9	-	-	PUNCT
dti-1294	55	10	nm	nm	PRON
dti-1294	55	11	pore	pore	ADJ
dti-1294	55	12	-	-	PUNCT
dti-1294	55	13	sized	sized	ADJ
dti-1294	55	14	polycarbonate	polycarbonate	ADJ
dti-1294	55	15	membrane	membrane	NOUN
dti-1294	55	16	under	under	ADP
dti-1294	55	17	nitrogen	nitrogen	NOUN
dti-1294	55	18	at	at	ADP
dti-1294	55	19	60o	60o	NOUN
dti-1294	55	20	c	c	NOUN
dti-1294	55	21	in	in	ADP
dti-1294	55	22	a	a	DET
dti-1294	55	23	lipid	lipid	NOUN
dti-1294	55	24	extruder	extruder	NOUN
dti-1294	55	25	(	(	PUNCT
dti-1294	55	26	lipextm	lipextm	ADJ
dti-1294	55	27	,	,	PUNCT
dti-1294	55	28	northern	northern	ADJ
dti-1294	55	29	lipids	lipids	PROPN
dti-1294	55	30	,	,	PUNCT
dti-1294	55	31	inc	inc	PROPN
dti-1294	55	32	.	.	PROPN
dti-1294	55	33	,	,	PUNCT
dti-1294	55	34	vancouver	vancouver	PROPN
dti-1294	55	35	,	,	PUNCT
dti-1294	55	36	canada	canada	PROPN
dti-1294	55	37	)	)	PUNCT
dti-1294	55	38	.	.	PUNCT
dti-1294	56	1	the	the	DET
dti-1294	56	2	mean	mean	ADJ
dti-1294	56	3	size	size	NOUN
dti-1294	56	4	of	of	ADP
dti-1294	56	5	the	the	DET
dti-1294	56	6	liposome	liposome	NOUN
dti-1294	56	7	particles	particle	NOUN
dti-1294	56	8	was	be	AUX
dti-1294	56	9	controlled	control	VERB
dti-1294	56	10	at	at	ADP
dti-1294	56	11	100	100	NUM
dti-1294	56	12	nm	nm	NOUN
dti-1294	56	13	in	in	ADP
dti-1294	56	14	diameter	diameter	NOUN
dti-1294	56	15	(	(	PUNCT
dti-1294	56	16	ishida	ishida	PROPN
dti-1294	56	17	et	et	PROPN
dti-1294	56	18	al	al	PROPN
dti-1294	56	19	.	.	PROPN
dti-1294	56	20	1999	1999	NUM
dti-1294	56	21	)	)	PUNCT
dti-1294	56	22	,	,	PUNCT
dti-1294	56	23	which	which	PRON
dti-1294	56	24	was	be	AUX
dti-1294	56	25	measured	measure	VERB
dti-1294	56	26	by	by	ADP
dti-1294	56	27	photon	photon	NOUN
dti-1294	56	28	-	-	PUNCT
dti-1294	56	29	correlation	correlation	NOUN
dti-1294	56	30	spectroscopy	spectroscopy	NOUN
dti-1294	56	31	on	on	ADP
dti-1294	56	32	a	a	DET
dti-1294	56	33	nicomp	nicomp	ADJ
dti-1294	56	34	370	370	NUM
dti-1294	56	35	submicron	submicron	NOUN
dti-1294	56	36	particle	particle	NOUN
dti-1294	56	37	analyzer	analyzer	NOUN
dti-1294	56	38	.	.	PUNCT
dti-1294	57	1	after	after	ADP
dti-1294	57	2	purifi	purifi	PROPN
dti-1294	57	3	ed	ed	NOUN
dti-1294	57	4	from	from	ADP
dti-1294	57	5	sepharose	sepharose	PROPN
dti-1294	57	6	cl-4b	cl-4b	PROPN
dti-1294	57	7	column	column	NOUN
dti-1294	57	8	,	,	PUNCT
dti-1294	57	9	the	the	DET
dti-1294	57	10	unilamellar	unilamellar	ADJ
dti-1294	57	11	liposome	liposome	NOUN
dti-1294	57	12	particles	particle	NOUN
dti-1294	57	13	were	be	AUX
dti-1294	57	14	remote	remote	ADV
dti-1294	57	15	-	-	PUNCT
dti-1294	57	16	loaded	load	VERB
dti-1294	57	17	with	with	ADP
dti-1294	57	18	doxorubicin	doxorubicin	PROPN
dti-1294	57	19	based	base	VERB
dti-1294	57	20	on	on	ADP
dti-1294	57	21	transmembrane	transmembrane	ADJ
dti-1294	57	22	ph	ph	NOUN
dti-1294	57	23	gradient	gradient	NOUN
dti-1294	57	24	of	of	ADP
dti-1294	57	25	4.0–7.4	4.0–7.4	NUM
dti-1294	57	26	.	.	PUNCT
dti-1294	58	1	the	the	DET
dti-1294	58	2	drug	drug	NOUN
dti-1294	58	3	-	-	PUNCT
dti-1294	58	4	tolipid	tolipid	VERB
dti-1294	58	5	weight	weight	NOUN
dti-1294	58	6	ratio	ratio	NOUN
dti-1294	58	7	was	be	AUX
dti-1294	58	8	at	at	ADP
dti-1294	58	9	1:10	1:10	NUM
dti-1294	58	10	(	(	PUNCT
dti-1294	58	11	wt	wt	NOUN
dti-1294	58	12	/	/	SYM
dti-1294	58	13	wt	wt	NOUN
dti-1294	58	14	)	)	PUNCT
dti-1294	58	15	.	.	PUNCT
dti-1294	59	1	the	the	DET
dti-1294	59	2	doxorubicin	doxorubicin	PROPN
dti-1294	59	3	containing	contain	VERB
dti-1294	59	4	liposome	liposome	NOUN
dti-1294	59	5	sample	sample	NOUN
dti-1294	59	6	was	be	AUX
dti-1294	59	7	purifi	purifi	ADJ
dti-1294	59	8	ed	ed	NOUN
dti-1294	59	9	by	by	ADP
dti-1294	59	10	passing	pass	VERB
dti-1294	59	11	through	through	ADP
dti-1294	59	12	sepharose	sepharose	NOUN
dti-1294	59	13	cl-4b	cl-4b	PROPN
dti-1294	59	14	column	column	NOUN
dti-1294	59	15	again	again	ADV
dti-1294	59	16	to	to	PART
dti-1294	59	17	separate	separate	VERB
dti-1294	59	18	off	off	ADP
dti-1294	59	19	small	small	ADJ
dti-1294	59	20	amount	amount	NOUN
dti-1294	59	21	of	of	ADP
dti-1294	59	22	free	free	ADJ
dti-1294	59	23	doxorubicin	doxorubicin	PROPN
dti-1294	59	24	.	.	PUNCT
dti-1294	60	1	then	then	ADV
dti-1294	60	2	the	the	DET
dti-1294	60	3	liposomal	liposomal	PROPN
dti-1294	60	4	doxorubicin	doxorubicin	PROPN
dti-1294	60	5	preparations	preparation	NOUN
dti-1294	60	6	were	be	AUX
dti-1294	60	7	diluted	dilute	VERB
dti-1294	60	8	in	in	ADP
dti-1294	60	9	ph	ph	PROPN
dti-1294	60	10	7.4	7.4	NUM
dti-1294	60	11	pbs	pbs	NOUN
dti-1294	60	12	to	to	PART
dti-1294	60	13	yield	yield	VERB
dti-1294	60	14	a	a	DET
dti-1294	60	15	doxorubicin	doxorubicin	ADJ
dti-1294	60	16	concentration	concentration	NOUN
dti-1294	60	17	of	of	ADP
dti-1294	60	18	1	1	NUM
dti-1294	60	19	mg	mg	NUM
dti-1294	60	20	/	/	SYM
dti-1294	61	1	ml	ml	NOUN
dti-1294	61	2	suspension	suspension	NOUN
dti-1294	61	3	.	.	PUNCT
dti-1294	62	1	the	the	DET
dti-1294	62	2	fi	fi	NOUN
dti-1294	62	3	nal	nal	ADJ
dti-1294	62	4	production	production	NOUN
dti-1294	62	5	of	of	ADP
dti-1294	62	6	liposomal	liposomal	ADJ
dti-1294	62	7	doxorubicin	doxorubicin	PROPN
dti-1294	62	8	samples	sample	NOUN
dti-1294	62	9	were	be	AUX
dti-1294	62	10	stored	store	VERB
dti-1294	62	11	under	under	ADP
dti-1294	62	12	4o	4o	NUM
dti-1294	62	13	c	c	NOUN
dti-1294	62	14	,	,	PUNCT
dti-1294	62	15	covered	cover	VERB
dti-1294	62	16	with	with	ADP
dti-1294	62	17	aluminum	aluminum	NOUN
dti-1294	62	18	foil	foil	NOUN
dti-1294	62	19	.	.	PUNCT
dti-1294	63	1	in	in	ADP
dti-1294	63	2	our	our	PRON
dti-1294	63	3	observations	observation	NOUN
dti-1294	63	4	the	the	DET
dti-1294	63	5	liposome	liposome	NOUN
dti-1294	63	6	sample	sample	NOUN
dti-1294	63	7	were	be	AUX
dti-1294	63	8	all	all	ADV
dti-1294	63	9	fresh	fresh	ADJ
dti-1294	63	10	made	make	VERB
dti-1294	63	11	and	and	CCONJ
dti-1294	63	12	used	use	VERB
dti-1294	63	13	within	within	ADP
dti-1294	63	14	one	one	NUM
dti-1294	63	15	month	month	NOUN
dti-1294	63	16	,	,	PUNCT
dti-1294	63	17	although	although	SCONJ
dti-1294	63	18	they	they	PRON
dti-1294	63	19	have	have	AUX
dti-1294	63	20	been	be	AUX
dti-1294	63	21	proven	prove	VERB
dti-1294	63	22	stable	stable	ADJ
dti-1294	63	23	for	for	ADP
dti-1294	63	24	much	much	ADV
dti-1294	63	25	longer	long	ADJ
dti-1294	63	26	time	time	NOUN
dti-1294	63	27	.	.	PUNCT
dti-1294	64	1	mice	mouse	NOUN
dti-1294	64	2	model	model	NOUN
dti-1294	64	3	of	of	ADP
dti-1294	64	4	l1210jf	l1210jf	VERB
dti-1294	64	5	solid	solid	ADJ
dti-1294	64	6	tumor	tumor	NOUN
dti-1294	64	7	murine	murine	ADJ
dti-1294	64	8	leukemia	leukemia	NOUN
dti-1294	64	9	l1210jf	l1210jf	PROPN
dti-1294	64	10	cells	cell	NOUN
dti-1294	64	11	were	be	AUX
dti-1294	64	12	cultured	cultured	ADJ
dti-1294	64	13	in	in	ADP
dti-1294	64	14	a	a	DET
dti-1294	64	15	folic	folic	ADJ
dti-1294	64	16	acid	acid	NOUN
dti-1294	64	17	free	free	ADJ
dti-1294	64	18	rpmi	rpmi	NOUN
dti-1294	64	19	1640	1640	NUM
dti-1294	64	20	medium	medium	NOUN
dti-1294	64	21	,	,	PUNCT
dti-1294	64	22	supplemented	supplement	VERB
dti-1294	64	23	with	with	ADP
dti-1294	64	24	10	10	NUM
dti-1294	64	25	%	%	NOUN
dti-1294	64	26	fetal	fetal	ADJ
dti-1294	64	27	calf	calf	NOUN
dti-1294	64	28	serum	serum	NOUN
dti-1294	64	29	,	,	PUNCT
dti-1294	64	30	100	100	NUM
dti-1294	64	31	u	u	NOUN
dti-1294	64	32	/	/	SYM
dti-1294	64	33	ml	ml	NOUN
dti-1294	64	34	penicillin	penicillin	NOUN
dti-1294	64	35	and	and	CCONJ
dti-1294	64	36	100	100	NUM
dti-1294	64	37	mg	mg	NUM
dti-1294	64	38	/	/	SYM
dti-1294	64	39	ml	ml	X
dti-1294	64	40	streptomycin	streptomycin	PROPN
dti-1294	64	41	,	,	PUNCT
dti-1294	64	42	in	in	ADP
dti-1294	64	43	a	a	DET
dti-1294	64	44	humidifi	humidifi	NOUN
dti-1294	64	45	ed	ed	NOUN
dti-1294	64	46	incubator	incubator	NOUN
dti-1294	64	47	,	,	PUNCT
dti-1294	64	48	atmosphere	atmosphere	NOUN
dti-1294	64	49	containing	contain	VERB
dti-1294	64	50	5	5	NUM
dti-1294	64	51	%	%	NOUN
dti-1294	64	52	co2	co2	NOUN
dti-1294	64	53	,	,	PUNCT
dti-1294	64	54	and	and	CCONJ
dti-1294	64	55	the	the	DET
dti-1294	64	56	temperature	temperature	NOUN
dti-1294	64	57	was	be	AUX
dti-1294	64	58	37o	37o	X
dti-1294	64	59	c.	c.	NOUN
dti-1294	64	60	before	before	ADP
dti-1294	64	61	injection	injection	NOUN
dti-1294	64	62	,	,	PUNCT
dti-1294	64	63	the	the	DET
dti-1294	64	64	cells	cell	NOUN
dti-1294	64	65	were	be	AUX
dti-1294	64	66	spun	spin	VERB
dti-1294	64	67	down	down	ADP
dti-1294	64	68	and	and	CCONJ
dti-1294	64	69	washed	wash	VERB
dti-1294	64	70	with	with	ADP
dti-1294	64	71	ph	ph	PROPN
dti-1294	64	72	7.4	7.4	NUM
dti-1294	64	73	pbs	pbs	NOUN
dti-1294	64	74	solution	solution	NOUN
dti-1294	64	75	three	three	NUM
dti-1294	64	76	times	time	NOUN
dti-1294	64	77	.	.	PUNCT
dti-1294	65	1	dba2	dba2	PROPN
dti-1294	65	2	mice	mouse	NOUN
dti-1294	65	3	weighting	weight	VERB
dti-1294	65	4	18–22	18–22	NUM
dti-1294	65	5	g	g	NOUN
dti-1294	65	6	were	be	AUX
dti-1294	65	7	purchased	purchase	VERB
dti-1294	65	8	from	from	ADP
dti-1294	65	9	charles	charles	PROPN
dti-1294	65	10	river	river	PROPN
dti-1294	65	11	laboratories	laboratory	NOUN
dti-1294	65	12	(	(	PUNCT
dti-1294	65	13	wilmington	wilmington	PROPN
dti-1294	65	14	,	,	PUNCT
dti-1294	65	15	massachusetts	massachusetts	PROPN
dti-1294	65	16	,	,	PUNCT
dti-1294	65	17	u.s.a	u.s.a	PROPN
dti-1294	65	18	.	.	PUNCT
dti-1294	65	19	)	)	PUNCT
dti-1294	65	20	.	.	PUNCT
dti-1294	66	1	the	the	DET
dti-1294	66	2	mice	mouse	NOUN
dti-1294	66	3	were	be	AUX
dti-1294	66	4	fed	feed	VERB
dti-1294	66	5	a	a	DET
dti-1294	66	6	folate	folate	NOUN
dti-1294	66	7	free	free	ADJ
dti-1294	66	8	special	special	ADJ
dti-1294	66	9	rodent	rodent	NOUN
dti-1294	66	10	diet	diet	NOUN
dti-1294	66	11	(	(	PUNCT
dti-1294	66	12	catalogue	catalogue	NOUN
dti-1294	66	13	no	no	NOUN
dti-1294	66	14	.	.	NOUN
dti-1294	66	15	117772	117772	NUM
dti-1294	66	16	,	,	PUNCT
dti-1294	66	17	dyets	dyets	PROPN
dti-1294	66	18	inc	inc	PROPN
dti-1294	66	19	.	.	PROPN
dti-1294	66	20	)	)	PUNCT
dti-1294	66	21	for	for	ADP
dti-1294	66	22	one	one	NUM
dti-1294	66	23	week	week	NOUN
dti-1294	66	24	before	before	ADP
dti-1294	66	25	use	use	NOUN
dti-1294	66	26	(	(	PUNCT
dti-1294	66	27	pan	pan	NOUN
dti-1294	66	28	et	et	PROPN
dti-1294	66	29	al	al	PROPN
dti-1294	66	30	.	.	PROPN
dti-1294	66	31	2003	2003	NUM
dti-1294	66	32	)	)	PUNCT
dti-1294	66	33	.	.	PUNCT
dti-1294	67	1	they	they	PRON
dti-1294	67	2	were	be	AUX
dti-1294	67	3	then	then	ADV
dti-1294	67	4	inoculated	inoculate	VERB
dti-1294	67	5	subcutaneously	subcutaneously	ADV
dti-1294	67	6	with	with	ADP
dti-1294	67	7	0.1	0.1	NUM
dti-1294	67	8	ml	ml	NOUN
dti-1294	67	9	suspension	suspension	NOUN
dti-1294	67	10	of	of	ADP
dti-1294	67	11	1	1	NUM
dti-1294	67	12	×	×	NOUN
dti-1294	67	13	106	106	NUM
dti-1294	67	14	l1210jf	l1210jf	PROPN
dti-1294	67	15	cells	cell	NOUN
dti-1294	67	16	in	in	ADP
dti-1294	67	17	pbs	pbs	PROPN
dti-1294	67	18	at	at	ADP
dti-1294	67	19	the	the	DET
dti-1294	67	20	left	left	PROPN
dti-1294	67	21	fl	fl	PROPN
dti-1294	67	22	ank	ank	PROPN
dti-1294	67	23	.	.	PUNCT
dti-1294	68	1	the	the	DET
dti-1294	68	2	tumor	tumor	NOUN
dti-1294	68	3	was	be	AUX
dti-1294	68	4	allowed	allow	VERB
dti-1294	68	5	to	to	PART
dti-1294	68	6	grow	grow	VERB
dti-1294	68	7	until	until	SCONJ
dti-1294	68	8	it	it	PRON
dti-1294	68	9	reached	reach	VERB
dti-1294	68	10	a	a	DET
dti-1294	68	11	size	size	NOUN
dti-1294	68	12	of	of	ADP
dti-1294	68	13	about	about	ADV
dti-1294	68	14	0.5	0.5	NUM
dti-1294	68	15	cm3	cm3	NOUN
dti-1294	68	16	.	.	PUNCT
dti-1294	69	1	in	in	ADP
dti-1294	69	2	our	our	PRON
dti-1294	69	3	animal	animal	NOUN
dti-1294	69	4	experiments	experiment	NOUN
dti-1294	69	5	,	,	PUNCT
dti-1294	69	6	all	all	DET
dti-1294	69	7	the	the	DET
dti-1294	69	8	procedures	procedure	NOUN
dti-1294	69	9	strictly	strictly	ADV
dti-1294	69	10	followed	follow	VERB
dti-1294	69	11	the	the	DET
dti-1294	69	12	regulations	regulation	NOUN
dti-1294	69	13	of	of	ADP
dti-1294	69	14	the	the	DET
dti-1294	69	15	ohio	ohio	PROPN
dti-1294	69	16	state	state	PROPN
dti-1294	69	17	university	university	PROPN
dti-1294	69	18	institutional	institutional	ADJ
dti-1294	69	19	animal	animal	NOUN
dti-1294	69	20	care	care	NOUN
dti-1294	69	21	and	and	CCONJ
dti-1294	69	22	use	use	NOUN
dti-1294	69	23	committee	committee	NOUN
dti-1294	69	24	.	.	PUNCT
dti-1294	70	1	cryosections	cryosection	NOUN
dti-1294	70	2	of	of	ADP
dti-1294	70	3	solid	solid	ADJ
dti-1294	70	4	tumor	tumor	NOUN
dti-1294	70	5	tissue	tissue	NOUN
dti-1294	70	6	sample	sample	NOUN
dti-1294	70	7	preparation	preparation	NOUN
dti-1294	70	8	.	.	PUNCT
dti-1294	71	1	each	each	DET
dti-1294	71	2	mouse	mouse	NOUN
dti-1294	71	3	was	be	AUX
dti-1294	71	4	injected	inject	VERB
dti-1294	71	5	through	through	ADP
dti-1294	71	6	the	the	DET
dti-1294	71	7	tail	tail	NOUN
dti-1294	71	8	vein	vein	NOUN
dti-1294	71	9	with	with	ADP
dti-1294	71	10	pegyl	pegyl	ADJ
dti-1294	71	11	-	-	PUNCT
dti-1294	71	12	dspc	dspc	NOUN
dti-1294	71	13	-	-	PUNCT
dti-1294	71	14	liposome	liposome	NOUN
dti-1294	71	15	sample	sample	NOUN
dti-1294	71	16	containing	contain	VERB
dti-1294	71	17	0.2	0.2	NUM
dti-1294	71	18	mg	mg	PROPN
dti-1294	71	19	doxorubicin	doxorubicin	PROPN
dti-1294	71	20	.	.	PUNCT
dti-1294	72	1	at	at	ADP
dti-1294	72	2	each	each	PRON
dti-1294	72	3	of	of	ADP
dti-1294	72	4	the	the	DET
dti-1294	72	5	selected	select	VERB
dti-1294	72	6	time	time	NOUN
dti-1294	72	7	points	point	NOUN
dti-1294	72	8	,	,	PUNCT
dti-1294	72	9	three	three	NUM
dti-1294	72	10	mice	mouse	NOUN
dti-1294	72	11	were	be	AUX
dti-1294	72	12	sacrifi	sacrifi	NOUN
dti-1294	72	13	ced	ce	VERB
dti-1294	72	14	with	with	ADP
dti-1294	72	15	co2	co2	NOUN
dti-1294	72	16	gas	gas	NOUN
dti-1294	72	17	.	.	PUNCT
dti-1294	73	1	then	then	ADV
dti-1294	73	2	the	the	DET
dti-1294	73	3	tumor	tumor	NOUN
dti-1294	73	4	tissues	tissue	NOUN
dti-1294	73	5	were	be	AUX
dti-1294	73	6	collected	collect	VERB
dti-1294	73	7	immediately	immediately	ADV
dti-1294	73	8	and	and	CCONJ
dti-1294	73	9	embedded	embed	VERB
dti-1294	73	10	into	into	ADP
dti-1294	73	11	tissue	tissue	NOUN
dti-1294	73	12	-	-	PUNCT
dti-1294	73	13	tek	tek	NOUN
dti-1294	73	14	o.c.t	o.c.t	NOUN
dti-1294	73	15	.	.	PUNCT
dti-1294	74	1	under	under	ADP
dti-1294	74	2	dry	dry	ADJ
dti-1294	74	3	ice	ice	NOUN
dti-1294	74	4	right	right	ADV
dti-1294	74	5	away	away	ADV
dti-1294	74	6	.	.	PUNCT
dti-1294	75	1	all	all	DET
dti-1294	75	2	the	the	DET
dti-1294	75	3	frozen	frozen	ADJ
dti-1294	75	4	samples	sample	NOUN
dti-1294	75	5	kept	keep	VERB
dti-1294	75	6	under	under	ADP
dti-1294	75	7	minus	minus	CCONJ
dti-1294	75	8	80oc	80oc	ADJ
dti-1294	75	9	before	before	ADP
dti-1294	75	10	use	use	NOUN
dti-1294	75	11	.	.	PUNCT
dti-1294	76	1	six	six	NUM
dti-1294	76	2	μm	μm	NUM
dti-1294	76	3	thick	thick	ADJ
dti-1294	76	4	cryosections	cryosection	NOUN
dti-1294	76	5	were	be	AUX
dti-1294	76	6	cut	cut	VERB
dti-1294	76	7	and	and	CCONJ
dti-1294	76	8	mounted	mount	VERB
dti-1294	76	9	on	on	ADP
dti-1294	76	10	positive	positive	ADJ
dti-1294	76	11	-	-	PUNCT
dti-1294	76	12	charged	charge	VERB
dti-1294	76	13	glass	glass	NOUN
dti-1294	76	14	slides	slide	NOUN
dti-1294	76	15	,	,	PUNCT
dti-1294	76	16	and	and	CCONJ
dti-1294	76	17	dried	dry	VERB
dti-1294	76	18	right	right	ADV
dti-1294	76	19	away	away	ADV
dti-1294	76	20	under	under	ADP
dti-1294	76	21	an	an	DET
dti-1294	76	22	electric	electric	ADJ
dti-1294	76	23	fan	fan	PROPN
dti-1294	76	24	.	.	PUNCT
dti-1294	77	1	the	the	DET
dti-1294	77	2	dried	dry	VERB
dti-1294	77	3	sections	section	NOUN
dti-1294	77	4	were	be	AUX
dti-1294	77	5	kept	keep	VERB
dti-1294	77	6	in	in	ADP
dti-1294	77	7	a	a	DET
dti-1294	77	8	minus	minus	NOUN
dti-1294	77	9	20o	20o	NOUN
dti-1294	77	10	c	c	NOUN
dti-1294	77	11	freezer	freezer	NOUN
dti-1294	77	12	before	before	ADP
dti-1294	77	13	staining	stain	VERB
dti-1294	77	14	.	.	PUNCT
dti-1294	78	1	the	the	DET
dti-1294	78	2	staining	stain	VERB
dti-1294	78	3	procedure	procedure	NOUN
dti-1294	78	4	was	be	AUX
dti-1294	78	5	processed	process	VERB
dti-1294	78	6	on	on	ADP
dti-1294	78	7	a	a	DET
dti-1294	78	8	dako	dako	PROPN
dti-1294	78	9	autostainer	autostainer	NOUN
dti-1294	78	10	.	.	PUNCT
dti-1294	79	1	briefl	briefl	PROPN
dti-1294	79	2	y	y	PROPN
dti-1294	79	3	,	,	PUNCT
dti-1294	79	4	fi	fi	NOUN
dti-1294	79	5	rst	rst	PROPN
dti-1294	80	1	the	the	DET
dti-1294	80	2	sections	section	NOUN
dti-1294	80	3	were	be	AUX
dti-1294	80	4	rehydrated	rehydrate	VERB
dti-1294	80	5	in	in	ADP
dti-1294	80	6	ph	ph	PROPN
dti-1294	80	7	7.4	7.4	NUM
dti-1294	80	8	pbs	pb	NOUN
dti-1294	80	9	,	,	PUNCT
dti-1294	80	10	and	and	CCONJ
dti-1294	80	11	blocked	block	VERB
dti-1294	80	12	with	with	ADP
dti-1294	80	13	10	10	NUM
dti-1294	80	14	%	%	NOUN
dti-1294	80	15	normal	normal	ADJ
dti-1294	80	16	rabbit	rabbit	NOUN
dti-1294	80	17	serum	serum	NOUN
dti-1294	80	18	.	.	PUNCT
dti-1294	81	1	a	a	DET
dti-1294	81	2	1:50	1:50	NUM
dti-1294	81	3	dilution	dilution	NOUN
dti-1294	81	4	of	of	ADP
dti-1294	81	5	rat	rat	NOUN
dti-1294	81	6	antimouse	antimouse	ADP
dti-1294	81	7	cd31	cd31	PROPN
dti-1294	81	8	primary	primary	ADJ
dti-1294	81	9	antibody	antibody	NOUN
dti-1294	81	10	was	be	AUX
dti-1294	81	11	applied	apply	VERB
dti-1294	81	12	and	and	CCONJ
dti-1294	81	13	then	then	ADV
dti-1294	81	14	the	the	DET
dti-1294	81	15	slides	slide	NOUN
dti-1294	81	16	were	be	AUX
dti-1294	81	17	incubated	incubate	VERB
dti-1294	81	18	for	for	ADP
dti-1294	81	19	30	30	NUM
dti-1294	81	20	minute	minute	NOUN
dti-1294	81	21	at	at	ADP
dti-1294	81	22	room	room	NOUN
dti-1294	81	23	temperature	temperature	NOUN
dti-1294	81	24	(	(	PUNCT
dti-1294	81	25	rubin	rubin	PROPN
dti-1294	81	26	et	et	PROPN
dti-1294	81	27	al	al	PROPN
dti-1294	81	28	.	.	PROPN
dti-1294	81	29	1999	1999	NUM
dti-1294	81	30	;	;	PUNCT
dti-1294	81	31	rogatsch	rogatsch	PROPN
dti-1294	81	32	et	et	PROPN
dti-1294	81	33	al	al	PROPN
dti-1294	81	34	.	.	PROPN
dti-1294	81	35	1997	1997	NUM
dti-1294	81	36	;	;	PUNCT
dti-1294	81	37	pan	pan	PROPN
dti-1294	81	38	et	et	PROPN
dti-1294	81	39	al	al	PROPN
dti-1294	81	40	.	.	PROPN
dti-1294	81	41	2004	2004	NUM
dti-1294	81	42	)	)	PUNCT
dti-1294	81	43	.	.	PUNCT
dti-1294	82	1	after	after	ADP
dti-1294	82	2	wash	wash	NOUN
dti-1294	82	3	,	,	PUNCT
dti-1294	82	4	a	a	DET
dti-1294	82	5	1:200	1:200	NUM
dti-1294	82	6	dilution	dilution	NOUN
dti-1294	82	7	of	of	ADP
dti-1294	82	8	biotinylated	biotinylated	ADJ
dti-1294	82	9	rabbit	rabbit	NOUN
dti-1294	82	10	anti	anti	ADJ
dti-1294	82	11	-	-	ADJ
dti-1294	82	12	rat	rat	ADJ
dti-1294	82	13	,	,	PUNCT
dti-1294	82	14	mouse	mouse	NOUN
dti-1294	82	15	absorbed	absorb	VERB
dti-1294	82	16	antibody	antibody	NOUN
dti-1294	82	17	was	be	AUX
dti-1294	82	18	used	use	VERB
dti-1294	82	19	as	as	ADP
dti-1294	82	20	the	the	DET
dti-1294	82	21	second	second	ADJ
dti-1294	82	22	antibody	antibody	NOUN
dti-1294	82	23	.	.	PUNCT
dti-1294	83	1	after	after	ADP
dti-1294	83	2	30	30	NUM
dti-1294	83	3	minutes	minute	NOUN
dti-1294	83	4	incubation	incubation	NOUN
dti-1294	83	5	,	,	PUNCT
dti-1294	83	6	the	the	DET
dti-1294	83	7	sections	section	NOUN
dti-1294	83	8	were	be	AUX
dti-1294	83	9	washed	wash	VERB
dti-1294	83	10	and	and	CCONJ
dti-1294	83	11	then	then	ADV
dti-1294	83	12	a	a	DET
dti-1294	83	13	1:40	1:40	NUM
dti-1294	83	14	dilution	dilution	NOUN
dti-1294	83	15	of	of	ADP
dti-1294	83	16	fitcstreptavidin	fitcstreptavidin	NOUN
dti-1294	83	17	solution	solution	NOUN
dti-1294	83	18	was	be	AUX
dti-1294	83	19	applied	apply	VERB
dti-1294	83	20	.	.	PUNCT
dti-1294	84	1	lastly	lastly	ADV
dti-1294	84	2	,	,	PUNCT
dti-1294	84	3	the	the	DET
dti-1294	84	4	slides	slide	NOUN
dti-1294	84	5	were	be	AUX
dti-1294	84	6	counterstained	counterstaine	VERB
dti-1294	84	7	with	with	ADP
dti-1294	84	8	fl	fl	PROPN
dti-1294	84	9	uorescent	uorescent	ADJ
dti-1294	84	10	dye	dye	PROPN
dti-1294	84	11	dapi	dapi	PROPN
dti-1294	84	12	contained	contain	VERB
dti-1294	84	13	mounting	mount	VERB
dti-1294	84	14	medium	medium	NOUN
dti-1294	84	15	to	to	PART
dti-1294	84	16	stain	stain	VERB
dti-1294	84	17	the	the	DET
dti-1294	84	18	alive	alive	ADJ
dti-1294	84	19	cell	cell	NOUN
dti-1294	84	20	nuclei	nucleus	NOUN
dti-1294	84	21	and	and	CCONJ
dti-1294	84	22	covered	cover	VERB
dti-1294	84	23	with	with	ADP
dti-1294	84	24	a	a	DET
dti-1294	84	25	regular	regular	ADJ
dti-1294	84	26	cover	cover	NOUN
dti-1294	84	27	glass	glass	NOUN
dti-1294	84	28	.	.	PUNCT
dti-1294	85	1	observation	observation	NOUN
dti-1294	85	2	on	on	ADP
dti-1294	85	3	the	the	DET
dti-1294	85	4	penetration	penetration	NOUN
dti-1294	85	5	and	and	CCONJ
dti-1294	85	6	distribution	distribution	NOUN
dti-1294	85	7	of	of	ADP
dti-1294	85	8	the	the	DET
dti-1294	85	9	liposomal	liposomal	ADJ
dti-1294	85	10	doxorubicin	doxorubicin	PROPN
dti-1294	85	11	stained	stain	VERB
dti-1294	85	12	cryosections	cryosection	NOUN
dti-1294	85	13	were	be	AUX
dti-1294	85	14	viewed	view	VERB
dti-1294	85	15	immediately	immediately	ADV
dti-1294	85	16	under	under	ADP
dti-1294	85	17	a	a	DET
dti-1294	85	18	zeiss	zeiss	PROPN
dti-1294	85	19	fl	fl	PROPN
dti-1294	85	20	uorescence	uorescence	NOUN
dti-1294	85	21	microscope	microscope	NOUN
dti-1294	85	22	.	.	PUNCT
dti-1294	86	1	a	a	DET
dti-1294	86	2	480	480	NUM
dti-1294	86	3	nm	nm	ADV
dti-1294	86	4	ultraviolet	ultraviolet	NOUN
dti-1294	86	5	exciting	exciting	ADJ
dti-1294	86	6	,	,	PUNCT
dti-1294	86	7	535	535	NUM
dti-1294	86	8	nm	nm	NOUN
dti-1294	86	9	emission	emission	NOUN
dti-1294	86	10	system	system	NOUN
dti-1294	86	11	was	be	AUX
dti-1294	86	12	used	use	VERB
dti-1294	86	13	for	for	ADP
dti-1294	86	14	green	green	ADJ
dti-1294	86	15	fl	fl	PROPN
dti-1294	86	16	uorescent	uorescent	ADJ
dti-1294	86	17	labeled	label	VERB
dti-1294	86	18	blood	blood	NOUN
dti-1294	86	19	vessel	vessel	NOUN
dti-1294	86	20	observation	observation	NOUN
dti-1294	86	21	,	,	PUNCT
dti-1294	86	22	and	and	CCONJ
dti-1294	86	23	360	360	NUM
dti-1294	86	24	nm/420	nm/420	NOUN
dti-1294	86	25	nm	nm	PRON
dti-1294	86	26	system	system	NOUN
dti-1294	86	27	was	be	AUX
dti-1294	86	28	applied	apply	VERB
dti-1294	86	29	for	for	ADP
dti-1294	86	30	observation	observation	NOUN
dti-1294	86	31	of	of	ADP
dti-1294	86	32	color	color	NOUN
dti-1294	86	33	fl	fl	PROPN
dti-1294	86	34	uorescent	uorescent	ADJ
dti-1294	86	35	labeled	label	VERB
dti-1294	86	36	cell	cell	NOUN
dti-1294	86	37	nuclei	nucleus	NOUN
dti-1294	86	38	and	and	CCONJ
dti-1294	86	39	a	a	DET
dti-1294	86	40	545	545	NUM
dti-1294	86	41	nm/610	nm/610	NOUN
dti-1294	86	42	nm	nm	ADJ
dti-1294	86	43	system	system	NOUN
dti-1294	86	44	was	be	AUX
dti-1294	86	45	used	use	VERB
dti-1294	86	46	for	for	ADP
dti-1294	86	47	red	red	ADJ
dti-1294	86	48	fl	fl	PROPN
dti-1294	86	49	uorescent	uorescent	ADJ
dti-1294	86	50	doxorubicin	doxorubicin	PROPN
dti-1294	86	51	containing	contain	VERB
dti-1294	86	52	liposome	liposome	NOUN
dti-1294	86	53	particle	particle	NOUN
dti-1294	86	54	observation	observation	NOUN
dti-1294	86	55	.	.	PUNCT
dti-1294	87	1	drug	drug	NOUN
dti-1294	87	2	target	target	NOUN
dti-1294	87	3	insights	insight	NOUN
dti-1294	87	4	2006	2006	NUM
dti-1294	87	5	:	:	PUNCT
dti-1294	87	6	132	132	NUM
dti-1294	87	7	pan	pan	NOUN
dti-1294	87	8	et	et	PROPN
dti-1294	87	9	al	al	PROPN
dti-1294	87	10	results	result	NOUN
dti-1294	87	11	and	and	CCONJ
dti-1294	87	12	discussion	discussion	VERB
dti-1294	87	13	the	the	DET
dti-1294	87	14	results	result	NOUN
dti-1294	87	15	of	of	ADP
dti-1294	87	16	the	the	DET
dti-1294	87	17	observation	observation	NOUN
dti-1294	87	18	showed	show	VERB
dti-1294	87	19	that	that	SCONJ
dti-1294	87	20	the	the	DET
dti-1294	87	21	methods	method	NOUN
dti-1294	87	22	used	use	VERB
dti-1294	87	23	in	in	ADP
dti-1294	87	24	cryosection	cryosection	NOUN
dti-1294	87	25	cutting	cutting	NOUN
dti-1294	87	26	,	,	PUNCT
dti-1294	87	27	the	the	DET
dti-1294	87	28	tissue	tissue	NOUN
dti-1294	87	29	stainings	staining	NOUN
dti-1294	87	30	and	and	CCONJ
dti-1294	87	31	the	the	DET
dti-1294	87	32	selection	selection	NOUN
dti-1294	87	33	of	of	ADP
dti-1294	87	34	the	the	DET
dti-1294	87	35	liposomes	liposome	NOUN
dti-1294	87	36	were	be	AUX
dti-1294	87	37	suitable	suitable	ADJ
dti-1294	87	38	.	.	PUNCT
dti-1294	88	1	the	the	DET
dti-1294	88	2	omission	omission	NOUN
dti-1294	88	3	of	of	ADP
dti-1294	88	4	the	the	DET
dti-1294	88	5	acetone	acetone	NOUN
dti-1294	88	6	fi	fi	NOUN
dti-1294	88	7	xing	xing	PROPN
dti-1294	88	8	step	step	NOUN
dti-1294	88	9	did	do	AUX
dti-1294	88	10	not	not	PART
dti-1294	88	11	interfere	interfere	VERB
dti-1294	88	12	the	the	DET
dti-1294	88	13	staining	staining	NOUN
dti-1294	88	14	of	of	ADP
dti-1294	88	15	the	the	DET
dti-1294	88	16	blood	blood	NOUN
dti-1294	88	17	vessel	vessel	NOUN
dti-1294	88	18	cells	cell	NOUN
dti-1294	88	19	and	and	CCONJ
dti-1294	88	20	the	the	DET
dti-1294	88	21	nuclei	nucleus	NOUN
dti-1294	88	22	of	of	ADP
dti-1294	88	23	the	the	DET
dti-1294	88	24	tumor	tumor	NOUN
dti-1294	88	25	cells	cell	NOUN
dti-1294	88	26	.	.	PUNCT
dti-1294	89	1	clearly	clearly	ADV
dti-1294	89	2	,	,	PUNCT
dti-1294	89	3	the	the	DET
dti-1294	89	4	red	red	ADJ
dti-1294	89	5	color	color	NOUN
dti-1294	89	6	doxorubicin	doxorubicin	PROPN
dti-1294	89	7	containing	contain	VERB
dti-1294	89	8	liposomal	liposomal	ADJ
dti-1294	89	9	particles	particle	NOUN
dti-1294	89	10	were	be	AUX
dti-1294	89	11	not	not	PART
dti-1294	89	12	penetrating	penetrate	VERB
dti-1294	89	13	out	out	ADP
dti-1294	89	14	from	from	ADP
dti-1294	89	15	the	the	DET
dti-1294	89	16	blood	blood	NOUN
dti-1294	89	17	vessel	vessel	NOUN
dti-1294	89	18	wall	wall	NOUN
dti-1294	89	19	,	,	PUNCT
dti-1294	89	20	since	since	SCONJ
dti-1294	89	21	the	the	DET
dti-1294	89	22	red	red	ADJ
dti-1294	89	23	color	color	NOUN
dti-1294	89	24	liposomal	liposomal	NOUN
dti-1294	89	25	particles	particle	NOUN
dti-1294	89	26	did	do	AUX
dti-1294	89	27	not	not	PART
dti-1294	89	28	distributed	distribute	VERB
dti-1294	89	29	along	along	ADP
dti-1294	89	30	the	the	DET
dti-1294	89	31	blood	blood	NOUN
dti-1294	89	32	vessels	vessel	NOUN
dti-1294	89	33	like	like	ADP
dti-1294	89	34	a	a	DET
dti-1294	89	35	sleeve	sleeve	NOUN
dti-1294	89	36	or	or	CCONJ
dti-1294	89	37	as	as	ADP
dti-1294	89	38	a	a	DET
dti-1294	89	39	cycle	cycle	NOUN
dti-1294	89	40	surround	surround	VERB
dti-1294	89	41	the	the	DET
dti-1294	89	42	cross	cross	NOUN
dti-1294	89	43	section	section	NOUN
dti-1294	89	44	of	of	ADP
dti-1294	89	45	the	the	DET
dti-1294	89	46	blood	blood	NOUN
dti-1294	89	47	vessel	vessel	NOUN
dti-1294	89	48	.	.	PUNCT
dti-1294	90	1	the	the	DET
dti-1294	90	2	liposomal	liposomal	ADJ
dti-1294	90	3	particles	particle	NOUN
dti-1294	90	4	were	be	AUX
dti-1294	90	5	only	only	ADV
dti-1294	90	6	passing	pass	VERB
dti-1294	90	7	though	though	SCONJ
dti-1294	90	8	the	the	DET
dti-1294	90	9	holes	hole	NOUN
dti-1294	90	10	of	of	ADP
dti-1294	90	11	the	the	DET
dti-1294	90	12	broken	broken	ADJ
dti-1294	90	13	blood	blood	NOUN
dti-1294	90	14	vessels	vessel	NOUN
dti-1294	90	15	with	with	ADP
dti-1294	90	16	a	a	DET
dti-1294	90	17	direction	direction	NOUN
dti-1294	90	18	and	and	CCONJ
dti-1294	90	19	spreading	spread	VERB
dti-1294	90	20	into	into	ADP
dti-1294	90	21	the	the	DET
dti-1294	90	22	cancer	cancer	NOUN
dti-1294	90	23	tissue	tissue	NOUN
dti-1294	90	24	in	in	ADP
dti-1294	90	25	the	the	DET
dti-1294	90	26	space	space	NOUN
dti-1294	90	27	between	between	ADP
dti-1294	90	28	the	the	DET
dti-1294	90	29	cells	cell	NOUN
dti-1294	90	30	in	in	ADP
dti-1294	90	31	the	the	DET
dti-1294	90	32	tumor	tumor	NOUN
dti-1294	90	33	tissue	tissue	NOUN
dti-1294	90	34	.	.	PUNCT
dti-1294	91	1	compare	compare	VERB
dti-1294	91	2	to	to	ADP
dti-1294	91	3	the	the	DET
dti-1294	91	4	total	total	ADJ
dti-1294	91	5	number	number	NOUN
dti-1294	91	6	of	of	ADP
dti-1294	91	7	blood	blood	NOUN
dti-1294	91	8	vessels	vessel	NOUN
dti-1294	91	9	in	in	ADP
dti-1294	91	10	the	the	DET
dti-1294	91	11	sections	section	NOUN
dti-1294	91	12	,	,	PUNCT
dti-1294	91	13	the	the	DET
dti-1294	91	14	number	number	NOUN
dti-1294	91	15	of	of	ADP
dti-1294	91	16	leaking	leak	VERB
dti-1294	91	17	blood	blood	NOUN
dti-1294	91	18	vessels	vessel	NOUN
dti-1294	91	19	were	be	AUX
dti-1294	91	20	limited	limit	VERB
dti-1294	91	21	in	in	ADP
dti-1294	91	22	our	our	PRON
dti-1294	91	23	l1210jf	l1210jf	NOUN
dti-1294	91	24	experimental	experimental	ADJ
dti-1294	91	25	cancer	cancer	NOUN
dti-1294	91	26	tissues	tissue	NOUN
dti-1294	91	27	.	.	PUNCT
dti-1294	92	1	those	those	DET
dti-1294	92	2	broken	break	VERB
dti-1294	92	3	blood	blood	NOUN
dti-1294	92	4	vessels	vessel	NOUN
dti-1294	92	5	commonly	commonly	ADV
dti-1294	92	6	located	locate	VERB
dti-1294	92	7	near	near	ADP
dti-1294	92	8	the	the	DET
dti-1294	92	9	necrosis	necrosis	NOUN
dti-1294	92	10	areas	area	NOUN
dti-1294	92	11	,	,	PUNCT
dti-1294	92	12	or	or	CCONJ
dti-1294	92	13	those	those	DET
dti-1294	92	14	areas	area	NOUN
dti-1294	92	15	where	where	SCONJ
dti-1294	92	16	the	the	DET
dti-1294	92	17	necrosis	necrosis	NOUN
dti-1294	92	18	is	be	AUX
dti-1294	92	19	starting	start	VERB
dti-1294	92	20	,	,	PUNCT
dti-1294	92	21	since	since	SCONJ
dti-1294	92	22	in	in	ADP
dti-1294	92	23	those	those	DET
dti-1294	92	24	necrosis	necrosis	NOUN
dti-1294	92	25	areas	area	NOUN
dti-1294	92	26	,	,	PUNCT
dti-1294	92	27	the	the	DET
dti-1294	92	28	number	number	NOUN
dti-1294	92	29	of	of	ADP
dti-1294	92	30	the	the	DET
dti-1294	92	31	cells	cell	NOUN
dti-1294	92	32	along	along	ADP
dti-1294	92	33	the	the	DET
dti-1294	92	34	blood	blood	NOUN
dti-1294	92	35	vessel	vessel	NOUN
dti-1294	92	36	were	be	AUX
dti-1294	92	37	high	high	ADJ
dti-1294	92	38	,	,	PUNCT
dti-1294	92	39	but	but	CCONJ
dti-1294	92	40	in	in	ADP
dti-1294	92	41	a	a	DET
dti-1294	92	42	short	short	ADJ
dti-1294	92	43	distance	distance	NOUN
dti-1294	92	44	showed	show	VERB
dti-1294	92	45	no	no	DET
dti-1294	92	46	many	many	ADJ
dti-1294	92	47	alive	alive	ADJ
dti-1294	92	48	cells	cell	NOUN
dti-1294	92	49	there	there	ADV
dti-1294	92	50	.	.	PUNCT
dti-1294	93	1	it	it	PRON
dti-1294	93	2	could	could	AUX
dti-1294	93	3	be	be	AUX
dti-1294	93	4	nicer	nice	ADJ
dti-1294	93	5	if	if	SCONJ
dti-1294	93	6	we	we	PRON
dti-1294	93	7	could	could	AUX
dti-1294	93	8	have	have	VERB
dti-1294	93	9	a	a	DET
dti-1294	93	10	chance	chance	NOUN
dti-1294	93	11	to	to	PART
dti-1294	93	12	quantitatively	quantitatively	ADV
dti-1294	93	13	determine	determine	VERB
dti-1294	93	14	the	the	DET
dti-1294	93	15	ratio	ratio	NOUN
dti-1294	93	16	or	or	CCONJ
dti-1294	93	17	the	the	DET
dti-1294	93	18	number	number	NOUN
dti-1294	93	19	of	of	ADP
dti-1294	93	20	leaking	leak	VERB
dti-1294	93	21	holes	hole	NOUN
dti-1294	93	22	in	in	ADP
dti-1294	93	23	different	different	ADJ
dti-1294	93	24	tumor	tumor	NOUN
dti-1294	93	25	tissue	tissue	NOUN
dti-1294	93	26	samples	sample	NOUN
dti-1294	93	27	,	,	PUNCT
dti-1294	93	28	however	however	ADV
dti-1294	93	29	,	,	PUNCT
dti-1294	93	30	from	from	ADP
dti-1294	93	31	our	our	PRON
dti-1294	93	32	observations	observation	NOUN
dti-1294	93	33	in	in	ADP
dti-1294	93	34	different	different	ADJ
dti-1294	93	35	experiments	experiment	NOUN
dti-1294	93	36	,	,	PUNCT
dti-1294	93	37	the	the	DET
dti-1294	93	38	frequency	frequency	NOUN
dti-1294	93	39	of	of	ADP
dti-1294	93	40	the	the	DET
dti-1294	93	41	necrosis	necrosis	NOUN
dti-1294	93	42	happening	happen	VERB
dti-1294	93	43	in	in	ADP
dti-1294	93	44	the	the	DET
dti-1294	93	45	tumor	tumor	NOUN
dti-1294	93	46	tissues	tissue	NOUN
dti-1294	93	47	might	might	AUX
dti-1294	93	48	different	different	ADJ
dti-1294	93	49	from	from	ADP
dti-1294	93	50	different	different	ADJ
dti-1294	93	51	species	specie	NOUN
dti-1294	93	52	of	of	ADP
dti-1294	93	53	the	the	DET
dti-1294	93	54	tumors	tumor	NOUN
dti-1294	93	55	,	,	PUNCT
dti-1294	93	56	and	and	CCONJ
dti-1294	93	57	determined	determine	VERB
dti-1294	93	58	by	by	ADP
dti-1294	93	59	the	the	DET
dti-1294	93	60	location	location	NOUN
dti-1294	93	61	on	on	ADP
dti-1294	93	62	back	back	ADV
dti-1294	93	63	or	or	CCONJ
dti-1294	93	64	at	at	ADP
dti-1294	93	65	the	the	DET
dti-1294	93	66	fl	fl	PROPN
dti-1294	93	67	ank	ank	PROPN
dti-1294	93	68	of	of	ADP
dti-1294	93	69	the	the	DET
dti-1294	93	70	mouse	mouse	NOUN
dti-1294	93	71	where	where	SCONJ
dti-1294	93	72	the	the	DET
dti-1294	93	73	tumor	tumor	NOUN
dti-1294	93	74	was	be	AUX
dti-1294	93	75	growing	grow	VERB
dti-1294	93	76	.	.	PUNCT
dti-1294	94	1	the	the	DET
dti-1294	94	2	level	level	NOUN
dti-1294	94	3	of	of	ADP
dti-1294	94	4	necrosis	necrosis	NOUN
dti-1294	94	5	also	also	ADV
dti-1294	94	6	related	relate	VERB
dti-1294	94	7	to	to	ADP
dti-1294	94	8	the	the	DET
dti-1294	94	9	size	size	NOUN
dti-1294	94	10	of	of	ADP
dti-1294	94	11	the	the	DET
dti-1294	94	12	tumor	tumor	NOUN
dti-1294	94	13	and	and	CCONJ
dti-1294	94	14	time	time	NOUN
dti-1294	94	15	how	how	SCONJ
dti-1294	94	16	long	long	ADV
dti-1294	94	17	the	the	DET
dti-1294	94	18	solid	solid	ADJ
dti-1294	94	19	cancer	cancer	NOUN
dti-1294	94	20	had	have	AUX
dti-1294	94	21	been	be	AUX
dti-1294	94	22	growing	grow	VERB
dti-1294	94	23	.	.	PUNCT
dti-1294	95	1	as	as	ADV
dti-1294	95	2	early	early	ADV
dti-1294	95	3	as	as	ADP
dti-1294	95	4	six	six	NUM
dti-1294	95	5	hours	hour	NOUN
dti-1294	95	6	after	after	ADP
dti-1294	95	7	liposome	liposome	NOUN
dti-1294	95	8	injection	injection	NOUN
dti-1294	95	9	,	,	PUNCT
dti-1294	95	10	the	the	DET
dti-1294	95	11	red	red	ADJ
dti-1294	95	12	color	color	NOUN
dti-1294	95	13	liposome	liposome	NOUN
dti-1294	95	14	particles	particle	NOUN
dti-1294	95	15	already	already	ADV
dti-1294	95	16	showing	show	VERB
dti-1294	95	17	in	in	ADP
dti-1294	95	18	the	the	DET
dti-1294	95	19	tumor	tumor	NOUN
dti-1294	95	20	tissue	tissue	NOUN
dti-1294	95	21	.	.	PUNCT
dti-1294	96	1	at	at	ADP
dti-1294	96	2	24	24	NUM
dti-1294	96	3	hours	hour	NOUN
dti-1294	96	4	after	after	ADP
dti-1294	96	5	liposome	liposome	NOUN
dti-1294	96	6	injection	injection	NOUN
dti-1294	96	7	the	the	DET
dti-1294	96	8	liposomal	liposomal	ADJ
dti-1294	96	9	particles	particle	NOUN
dti-1294	96	10	spread	spread	VERB
dti-1294	96	11	out	out	ADP
dti-1294	96	12	for	for	ADP
dti-1294	96	13	a	a	DET
dti-1294	96	14	longer	long	ADJ
dti-1294	96	15	distances	distance	NOUN
dti-1294	96	16	and	and	CCONJ
dti-1294	96	17	then	then	ADV
dti-1294	96	18	the	the	DET
dti-1294	96	19	liposomal	liposomal	ADJ
dti-1294	96	20	particles	particle	NOUN
dti-1294	96	21	stopped	stop	VERB
dti-1294	96	22	leaking	leak	VERB
dti-1294	96	23	out	out	ADP
dti-1294	96	24	from	from	ADP
dti-1294	96	25	the	the	DET
dti-1294	96	26	blood	blood	NOUN
dti-1294	96	27	vessel	vessel	NOUN
dti-1294	96	28	at	at	ADP
dti-1294	96	29	about	about	ADV
dti-1294	96	30	48	48	NUM
dti-1294	96	31	hours	hour	NOUN
dti-1294	96	32	after	after	ADP
dti-1294	96	33	liposome	liposome	NOUN
dti-1294	96	34	injection	injection	NOUN
dti-1294	96	35	.	.	PUNCT
dti-1294	97	1	in	in	ADP
dti-1294	97	2	this	this	DET
dti-1294	97	3	paper	paper	NOUN
dti-1294	97	4	,	,	PUNCT
dti-1294	97	5	for	for	ADP
dti-1294	97	6	showing	show	VERB
dti-1294	97	7	the	the	DET
dti-1294	97	8	clearer	clear	ADJ
dti-1294	97	9	picture	picture	NOUN
dti-1294	97	10	of	of	ADP
dti-1294	97	11	the	the	DET
dti-1294	97	12	way	way	NOUN
dti-1294	97	13	by	by	ADP
dti-1294	97	14	which	which	PRON
dti-1294	97	15	non	non	ADJ
dti-1294	97	16	-	-	ADJ
dti-1294	97	17	targeted	targeted	ADJ
dti-1294	97	18	and	and	CCONJ
dti-1294	97	19	folic	folic	ADJ
dti-1294	97	20	acid	acid	NOUN
dti-1294	97	21	targeted	target	VERB
dti-1294	97	22	liposomal	liposomal	ADJ
dti-1294	97	23	particles	particle	NOUN
dti-1294	97	24	penetrating	penetrate	VERB
dti-1294	97	25	out	out	ADV
dti-1294	97	26	from	from	ADP
dti-1294	97	27	the	the	DET
dti-1294	97	28	blood	blood	NOUN
dti-1294	97	29	vessel	vessel	NOUN
dti-1294	97	30	,	,	PUNCT
dti-1294	97	31	we	we	PRON
dti-1294	97	32	showed	show	VERB
dti-1294	97	33	two	two	NUM
dti-1294	97	34	photos	photo	NOUN
dti-1294	97	35	for	for	ADP
dti-1294	97	36	each	each	DET
dti-1294	97	37	liposome	liposome	NOUN
dti-1294	97	38	and	and	CCONJ
dti-1294	97	39	all	all	PRON
dti-1294	97	40	of	of	ADP
dti-1294	97	41	tumor	tumor	NOUN
dti-1294	97	42	tissue	tissue	NOUN
dti-1294	97	43	samples	sample	NOUN
dti-1294	97	44	were	be	AUX
dti-1294	97	45	taken	take	VERB
dti-1294	97	46	at	at	ADP
dti-1294	97	47	the	the	DET
dti-1294	97	48	time	time	NOUN
dti-1294	97	49	12	12	NUM
dti-1294	97	50	hours	hour	NOUN
dti-1294	97	51	after	after	ADP
dti-1294	97	52	liposome	liposome	NOUN
dti-1294	97	53	injection	injection	NOUN
dti-1294	97	54	(	(	PUNCT
dti-1294	97	55	see	see	VERB
dti-1294	97	56	fig	fig	NOUN
dti-1294	97	57	.	.	PUNCT
dti-1294	98	1	1	1	NUM
dti-1294	98	2	)	)	PUNCT
dti-1294	98	3	.	.	PUNCT
dti-1294	99	1	in	in	ADP
dti-1294	99	2	figure	figure	NOUN
dti-1294	99	3	1	1	NUM
dti-1294	99	4	,	,	PUNCT
dti-1294	99	5	a	a	PRON
dti-1294	99	6	and	and	CCONJ
dti-1294	99	7	b	b	NOUN
dti-1294	99	8	showing	show	VERB
dti-1294	99	9	the	the	DET
dti-1294	99	10	non	non	ADJ
dti-1294	99	11	-	-	ADJ
dti-1294	99	12	targeting	targeting	ADJ
dti-1294	99	13	liposomal	liposomal	ADJ
dti-1294	99	14	doxorubicin	doxorubicin	PROPN
dti-1294	99	15	particles	particle	NOUN
dti-1294	99	16	penetrating	penetrate	VERB
dti-1294	99	17	in	in	ADP
dti-1294	99	18	l1210jf	l1210jf	NOUN
dti-1294	99	19	solid	solid	ADJ
dti-1294	99	20	tumor	tumor	NOUN
dti-1294	99	21	tissue	tissue	NOUN
dti-1294	99	22	;	;	PUNCT
dti-1294	99	23	c	c	PROPN
dti-1294	99	24	and	and	CCONJ
dti-1294	99	25	d	d	PROPN
dti-1294	99	26	are	be	AUX
dti-1294	99	27	showing	show	VERB
dti-1294	99	28	the	the	DET
dti-1294	99	29	folic	folic	ADJ
dti-1294	99	30	acid	acid	NOUN
dti-1294	99	31	targeted	target	VERB
dti-1294	99	32	liposomal	liposomal	ADJ
dti-1294	99	33	doxorubicin	doxorubicin	PROPN
dti-1294	99	34	particles	particle	NOUN
dti-1294	99	35	penetrating	penetrate	VERB
dti-1294	99	36	in	in	ADP
dti-1294	99	37	l1210jf	l1210jf	NOUN
dti-1294	99	38	solid	solid	ADJ
dti-1294	99	39	tumors	tumor	NOUN
dti-1294	99	40	.	.	PUNCT
dti-1294	100	1	no	no	DET
dti-1294	100	2	obvious	obvious	ADJ
dti-1294	100	3	differences	difference	NOUN
dti-1294	100	4	could	could	AUX
dti-1294	100	5	be	be	AUX
dti-1294	100	6	pointed	point	VERB
dti-1294	100	7	out	out	ADP
dti-1294	100	8	in	in	ADP
dti-1294	100	9	figure	figure	NOUN
dti-1294	100	10	between	between	ADP
dti-1294	100	11	the	the	DET
dti-1294	100	12	non	non	ADJ
dti-1294	100	13	-	-	ADJ
dti-1294	100	14	targeted	targeted	ADJ
dti-1294	100	15	liposome	liposome	NOUN
dti-1294	100	16	and	and	CCONJ
dti-1294	100	17	folic	folic	NOUN
dti-1294	100	18	acid	acid	NOUN
dti-1294	100	19	targeted	target	VERB
dti-1294	100	20	liposome	liposome	NOUN
dti-1294	100	21	,	,	PUNCT
dti-1294	100	22	only	only	ADV
dti-1294	100	23	the	the	DET
dti-1294	100	24	diffusion	diffusion	NOUN
dti-1294	100	25	of	of	ADP
dti-1294	100	26	the	the	DET
dti-1294	100	27	folic	folic	ADJ
dti-1294	100	28	acid	acid	NOUN
dti-1294	100	29	targeted	target	VERB
dti-1294	100	30	liposomal	liposomal	ADJ
dti-1294	100	31	particles	particle	NOUN
dti-1294	100	32	looked	look	VERB
dti-1294	100	33	faster	fast	ADV
dti-1294	100	34	.	.	PUNCT
dti-1294	101	1	we	we	PRON
dti-1294	101	2	have	have	AUX
dti-1294	101	3	been	be	AUX
dti-1294	101	4	wary	wary	ADJ
dti-1294	101	5	about	about	ADP
dti-1294	101	6	that	that	SCONJ
dti-1294	101	7	the	the	DET
dti-1294	101	8	low	low	ADJ
dti-1294	101	9	temperature	temperature	NOUN
dti-1294	101	10	frozen	frozen	ADJ
dti-1294	101	11	cryosection	cryosection	NOUN
dti-1294	101	12	cutting	cutting	NOUN
dti-1294	101	13	step	step	NOUN
dti-1294	101	14	might	might	AUX
dti-1294	101	15	break	break	VERB
dti-1294	101	16	the	the	DET
dti-1294	101	17	liposomal	liposomal	ADJ
dti-1294	101	18	particles	particle	NOUN
dti-1294	101	19	or	or	CCONJ
dti-1294	101	20	changed	change	VERB
dti-1294	101	21	particle	particle	NOUN
dti-1294	101	22	size	size	NOUN
dti-1294	101	23	.	.	PUNCT
dti-1294	102	1	but	but	CCONJ
dti-1294	102	2	,	,	PUNCT
dti-1294	102	3	from	from	ADP
dti-1294	102	4	the	the	DET
dti-1294	102	5	results	result	NOUN
dti-1294	102	6	we	we	PRON
dti-1294	102	7	obtained	obtain	VERB
dti-1294	102	8	,	,	PUNCT
dti-1294	102	9	we	we	PRON
dti-1294	102	10	believed	believe	VERB
dti-1294	102	11	that	that	PRON
dti-1294	102	12	was	be	AUX
dti-1294	102	13	not	not	PART
dti-1294	102	14	happened	happen	VERB
dti-1294	102	15	,	,	PUNCT
dti-1294	102	16	or	or	CCONJ
dti-1294	102	17	only	only	ADV
dti-1294	102	18	happened	happen	VERB
dti-1294	102	19	at	at	ADP
dti-1294	102	20	very	very	ADV
dti-1294	102	21	limited	limited	ADJ
dti-1294	102	22	level	level	NOUN
dti-1294	102	23	.	.	PUNCT
dti-1294	103	1	anyway	anyway	ADV
dti-1294	103	2	,	,	PUNCT
dti-1294	103	3	even	even	ADV
dti-1294	103	4	it	it	PRON
dti-1294	103	5	happened	happen	VERB
dti-1294	103	6	,	,	PUNCT
dti-1294	103	7	at	at	ADP
dti-1294	103	8	the	the	DET
dti-1294	103	9	time	time	NOUN
dti-1294	103	10	the	the	DET
dti-1294	103	11	crysections	crysection	NOUN
dti-1294	103	12	were	be	AUX
dti-1294	103	13	cutting	cut	VERB
dti-1294	103	14	,	,	PUNCT
dti-1294	103	15	the	the	DET
dti-1294	103	16	liposome	liposome	NOUN
dti-1294	103	17	particles	particle	NOUN
dti-1294	103	18	already	already	ADV
dti-1294	103	19	leaked	leak	VERB
dti-1294	103	20	out	out	ADP
dti-1294	103	21	from	from	ADP
dti-1294	103	22	the	the	DET
dti-1294	103	23	blood	blood	NOUN
dti-1294	103	24	vessel	vessel	NOUN
dti-1294	103	25	,	,	PUNCT
dti-1294	103	26	the	the	DET
dti-1294	103	27	size	size	NOUN
dti-1294	103	28	change	change	NOUN
dti-1294	103	29	at	at	ADP
dti-1294	103	30	that	that	DET
dti-1294	103	31	time	time	NOUN
dti-1294	103	32	will	will	AUX
dti-1294	103	33	not	not	PART
dti-1294	103	34	interfere	interfere	VERB
dti-1294	103	35	our	our	PRON
dti-1294	103	36	observation	observation	NOUN
dti-1294	103	37	.	.	PUNCT
dti-1294	104	1	also	also	ADV
dti-1294	104	2	under	under	ADP
dti-1294	104	3	the	the	DET
dti-1294	104	4	experimental	experimental	ADJ
dti-1294	104	5	condition	condition	NOUN
dti-1294	104	6	the	the	DET
dti-1294	104	7	limited	limited	ADJ
dti-1294	104	8	amount	amount	NOUN
dti-1294	104	9	of	of	ADP
dti-1294	104	10	free	free	ADJ
dti-1294	104	11	doxorubicin	doxorubicin	NOUN
dti-1294	104	12	which	which	PRON
dti-1294	104	13	leaked	leak	VERB
dti-1294	104	14	out	out	ADP
dti-1294	104	15	from	from	ADP
dti-1294	104	16	the	the	DET
dti-1294	104	17	broken	break	VERB
dti-1294	104	18	liposomal	liposomal	ADJ
dti-1294	104	19	particles	particle	NOUN
dti-1294	104	20	would	would	AUX
dti-1294	104	21	be	be	AUX
dti-1294	104	22	wash	wash	VERB
dti-1294	104	23	off	off	ADP
dti-1294	104	24	from	from	ADP
dti-1294	104	25	the	the	DET
dti-1294	104	26	thin	thin	ADJ
dti-1294	104	27	section	section	NOUN
dti-1294	104	28	tissue	tissue	NOUN
dti-1294	104	29	during	during	ADP
dti-1294	104	30	the	the	DET
dti-1294	104	31	staining	stain	VERB
dti-1294	104	32	procedure	procedure	NOUN
dti-1294	104	33	,	,	PUNCT
dti-1294	104	34	it	it	PRON
dti-1294	104	35	would	would	AUX
dti-1294	104	36	not	not	PART
dti-1294	104	37	be	be	AUX
dti-1294	104	38	seeable	seeable	ADJ
dti-1294	104	39	.	.	PUNCT
dti-1294	105	1	as	as	SCONJ
dti-1294	105	2	showed	show	VERB
dti-1294	105	3	quite	quite	ADV
dti-1294	105	4	often	often	ADV
dti-1294	105	5	,	,	PUNCT
dti-1294	105	6	that	that	SCONJ
dti-1294	105	7	there	there	PRON
dti-1294	105	8	are	be	VERB
dti-1294	105	9	not	not	PART
dti-1294	105	10	many	many	ADJ
dti-1294	105	11	living	living	NOUN
dti-1294	105	12	cells	cell	NOUN
dti-1294	105	13	near	near	ADP
dti-1294	105	14	the	the	DET
dti-1294	105	15	leaking	leak	VERB
dti-1294	105	16	blood	blood	NOUN
dti-1294	105	17	vessels	vessel	NOUN
dti-1294	105	18	,	,	PUNCT
dti-1294	105	19	we	we	PRON
dti-1294	105	20	believe	believe	VERB
dti-1294	105	21	those	those	DET
dti-1294	105	22	broken	broken	ADJ
dti-1294	105	23	blood	blood	NOUN
dti-1294	105	24	vessels	vessel	NOUN
dti-1294	105	25	are	be	AUX
dti-1294	105	26	located	locate	VERB
dti-1294	105	27	closely	closely	ADV
dti-1294	105	28	to	to	ADP
dti-1294	105	29	the	the	DET
dti-1294	105	30	necrotic	necrotic	ADJ
dti-1294	105	31	areas	area	NOUN
dti-1294	105	32	or	or	CCONJ
dti-1294	105	33	those	those	DET
dti-1294	105	34	areas	area	NOUN
dti-1294	105	35	where	where	SCONJ
dti-1294	105	36	the	the	DET
dti-1294	105	37	solid	solid	ADJ
dti-1294	105	38	tumor	tumor	NOUN
dti-1294	105	39	tissue	tissue	NOUN
dti-1294	105	40	was	be	AUX
dti-1294	105	41	starting	start	VERB
dti-1294	105	42	to	to	PART
dti-1294	105	43	form	form	VERB
dti-1294	105	44	necrotic	necrotic	ADJ
dti-1294	105	45	area	area	NOUN
dti-1294	105	46	.	.	PUNCT
dti-1294	106	1	lately	lately	ADV
dti-1294	106	2	,	,	PUNCT
dti-1294	106	3	kirpotin	kirpotin	PROPN
dti-1294	106	4	et	et	PROPN
dti-1294	106	5	al	al	PROPN
dti-1294	106	6	.	.	PROPN
dti-1294	106	7	observed	observe	VERB
dti-1294	106	8	the	the	DET
dti-1294	106	9	distribution	distribution	NOUN
dti-1294	106	10	and	and	CCONJ
dti-1294	106	11	up	up	ADV
dti-1294	106	12	taken	take	VERB
dti-1294	106	13	of	of	ADP
dti-1294	106	14	anti	anti	ADJ
dti-1294	106	15	-	-	ADJ
dti-1294	106	16	her2	her2	ADJ
dti-1294	106	17	antibody	antibody	NOUN
dti-1294	106	18	targeted	target	VERB
dti-1294	106	19	long	long	ADV
dti-1294	106	20	circulating	circulate	VERB
dti-1294	106	21	liposomal	liposomal	NOUN
dti-1294	106	22	doxorubicin	doxorubicin	PROPN
dti-1294	106	23	particles	particle	NOUN
dti-1294	106	24	and	and	CCONJ
dti-1294	106	25	its	its	PRON
dti-1294	106	26	correlated	correlate	VERB
dti-1294	106	27	non	non	ADJ
dti-1294	106	28	-	-	ADJ
dti-1294	106	29	targeted	targeted	ADJ
dti-1294	106	30	liposome	liposome	NOUN
dti-1294	106	31	in	in	ADP
dti-1294	106	32	her2	her2	PROPN
dti-1294	106	33	expressed	express	VERB
dti-1294	106	34	bt-474	bt-474	PROPN
dti-1294	106	35	cell	cell	NOUN
dti-1294	106	36	solid	solid	ADJ
dti-1294	106	37	tumor	tumor	NOUN
dti-1294	106	38	and	and	CCONJ
dti-1294	106	39	non	non	ADJ
dti-1294	106	40	-	-	ADJ
dti-1294	106	41	her2	her2	ADJ
dti-1294	106	42	antigen	antigen	PROPN
dti-1294	106	43	expressed	express	VERB
dti-1294	106	44	mcf-7	mcf-7	NOUN
dti-1294	106	45	cell	cell	NOUN
dti-1294	106	46	solid	solid	ADJ
dti-1294	106	47	tumor	tumor	NOUN
dti-1294	106	48	in	in	ADP
dti-1294	106	49	nude	nude	ADJ
dti-1294	106	50	mice	mouse	NOUN
dti-1294	106	51	(	(	PUNCT
dti-1294	106	52	kirpotin	kirpotin	PROPN
dti-1294	106	53	et	et	PROPN
dti-1294	106	54	al	al	PROPN
dti-1294	106	55	.	.	PROPN
dti-1294	106	56	2006	2006	NUM
dti-1294	106	57	)	)	PUNCT
dti-1294	106	58	.	.	PUNCT
dti-1294	107	1	in	in	ADP
dti-1294	107	2	their	their	PRON
dti-1294	107	3	report	report	NOUN
dti-1294	107	4	,	,	PUNCT
dti-1294	107	5	the	the	DET
dti-1294	107	6	amount	amount	NOUN
dti-1294	107	7	of	of	ADP
dti-1294	107	8	liposomal	liposomal	ADJ
dti-1294	107	9	particles	particle	NOUN
dti-1294	107	10	distributed	distribute	VERB
dti-1294	107	11	into	into	ADP
dti-1294	107	12	the	the	DET
dti-1294	107	13	solid	solid	ADJ
dti-1294	107	14	tumor	tumor	NOUN
dti-1294	107	15	tissues	tissue	NOUN
dti-1294	107	16	were	be	AUX
dti-1294	107	17	the	the	DET
dti-1294	107	18	same	same	ADJ
dti-1294	107	19	,	,	PUNCT
dti-1294	107	20	no	no	DET
dti-1294	107	21	difference	difference	NOUN
dti-1294	107	22	in	in	ADP
dti-1294	107	23	both	both	DET
dti-1294	107	24	antigen	antigen	NOUN
dti-1294	107	25	expressed	express	VERB
dti-1294	107	26	bt-474	bt-474	PROPN
dti-1294	107	27	solid	solid	ADJ
dti-1294	107	28	tumor	tumor	NOUN
dti-1294	107	29	or	or	CCONJ
dti-1294	107	30	her2	her2	VERB
dti-1294	107	31	antigen	antigen	NOUN
dti-1294	107	32	not	not	PART
dti-1294	107	33	expressed	express	VERB
dti-1294	107	34	mcf-7	mcf-7	NOUN
dti-1294	107	35	solid	solid	ADJ
dti-1294	107	36	tumor	tumor	NOUN
dti-1294	107	37	.	.	PUNCT
dti-1294	108	1	and	and	CCONJ
dti-1294	108	2	no	no	DET
dti-1294	108	3	difference	difference	NOUN
dti-1294	108	4	between	between	ADP
dti-1294	108	5	the	the	DET
dti-1294	108	6	antibody	antibody	NOUN
dti-1294	108	7	targeted	target	VERB
dti-1294	108	8	or	or	CCONJ
dti-1294	108	9	non	non	ADJ
dti-1294	108	10	-	-	ADJ
dti-1294	108	11	targeted	targeted	ADJ
dti-1294	108	12	liposome	liposome	NOUN
dti-1294	108	13	.	.	PUNCT
dti-1294	109	1	it	it	PRON
dti-1294	109	2	is	be	AUX
dti-1294	109	3	agreeable	agreeable	ADJ
dti-1294	109	4	,	,	PUNCT
dti-1294	109	5	the	the	DET
dti-1294	109	6	amount	amount	NOUN
dti-1294	109	7	of	of	ADP
dti-1294	109	8	liposomal	liposomal	ADJ
dti-1294	109	9	particles	particle	NOUN
dti-1294	109	10	can	can	AUX
dti-1294	109	11	penetrate	penetrate	VERB
dti-1294	109	12	into	into	ADP
dti-1294	109	13	solid	solid	ADJ
dti-1294	109	14	tumor	tumor	NOUN
dti-1294	109	15	tissue	tissue	NOUN
dti-1294	109	16	is	be	AUX
dti-1294	109	17	determined	determine	VERB
dti-1294	109	18	by	by	ADP
dti-1294	109	19	the	the	DET
dti-1294	109	20	hole	hole	NOUN
dti-1294	109	21	size	size	NOUN
dti-1294	109	22	and	and	CCONJ
dti-1294	109	23	number	number	NOUN
dti-1294	109	24	of	of	ADP
dti-1294	109	25	the	the	DET
dti-1294	109	26	blood	blood	NOUN
dti-1294	109	27	vessels	vessel	NOUN
dti-1294	109	28	,	,	PUNCT
dti-1294	109	29	but	but	CCONJ
dti-1294	109	30	not	not	PART
dti-1294	109	31	determined	determine	VERB
dti-1294	109	32	by	by	ADP
dti-1294	109	33	the	the	DET
dti-1294	109	34	targeting	targeting	NOUN
dti-1294	109	35	group	group	NOUN
dti-1294	109	36	which	which	PRON
dti-1294	109	37	located	locate	VERB
dti-1294	109	38	on	on	ADP
dti-1294	109	39	the	the	DET
dti-1294	109	40	liposomal	liposomal	ADJ
dti-1294	109	41	particle	particle	NOUN
dti-1294	109	42	surface	surface	NOUN
dti-1294	109	43	.	.	PUNCT
dti-1294	110	1	however	however	ADV
dti-1294	110	2	,	,	PUNCT
dti-1294	110	3	after	after	SCONJ
dti-1294	110	4	got	get	VERB
dti-1294	110	5	into	into	ADP
dti-1294	110	6	the	the	DET
dti-1294	110	7	tumor	tumor	NOUN
dti-1294	110	8	tissue	tissue	NOUN
dti-1294	110	9	the	the	DET
dti-1294	110	10	functional	functional	ADJ
dti-1294	110	11	folic	folic	ADJ
dti-1294	110	12	acid	acid	NOUN
dti-1294	110	13	ligands	ligand	NOUN
dti-1294	110	14	bound	bind	VERB
dti-1294	110	15	on	on	ADP
dti-1294	110	16	to	to	ADP
dti-1294	110	17	folic	folic	ADJ
dti-1294	110	18	acid	acid	NOUN
dti-1294	110	19	receptors	receptor	NOUN
dti-1294	110	20	.	.	PUNCT
dti-1294	111	1	besides	besides	SCONJ
dti-1294	111	2	,	,	PUNCT
dti-1294	111	3	as	as	SCONJ
dti-1294	111	4	it	it	PRON
dti-1294	111	5	was	be	AUX
dti-1294	111	6	already	already	ADV
dti-1294	111	7	reported	report	VERB
dti-1294	111	8	that	that	SCONJ
dti-1294	111	9	a	a	DET
dti-1294	111	10	number	number	NOUN
dti-1294	111	11	activated	activate	VERB
dti-1294	111	12	macrophages	macrophage	NOUN
dti-1294	111	13	were	be	AUX
dti-1294	111	14	presenting	present	VERB
dti-1294	111	15	in	in	ADP
dti-1294	111	16	the	the	DET
dti-1294	111	17	solid	solid	ADJ
dti-1294	111	18	tumor	tumor	NOUN
dti-1294	111	19	tissue	tissue	NOUN
dti-1294	111	20	(	(	PUNCT
dti-1294	111	21	murdoch	murdoch	PROPN
dti-1294	111	22	et	et	PROPN
dti-1294	111	23	al	al	PROPN
dti-1294	111	24	.	.	PROPN
dti-1294	111	25	2004	2004	NUM
dti-1294	111	26	)	)	PUNCT
dti-1294	112	1	they	they	PRON
dti-1294	112	2	also	also	ADV
dti-1294	112	3	actively	actively	ADV
dti-1294	112	4	expressing	express	VERB
dti-1294	112	5	folic	folic	ADJ
dti-1294	112	6	acid	acid	NOUN
dti-1294	112	7	receptors	receptor	NOUN
dti-1294	112	8	on	on	ADP
dti-1294	112	9	their	their	PRON
dti-1294	112	10	surface	surface	NOUN
dti-1294	112	11	.	.	PUNCT
dti-1294	113	1	so	so	ADV
dti-1294	113	2	,	,	PUNCT
dti-1294	113	3	in	in	ADP
dti-1294	113	4	our	our	PRON
dti-1294	113	5	folic	folic	ADJ
dti-1294	113	6	acid	acid	NOUN
dti-1294	113	7	targeted	target	VERB
dti-1294	113	8	liposomal	liposomal	ADJ
dti-1294	113	9	particle	particle	NOUN
dti-1294	113	10	case	case	NOUN
dti-1294	113	11	,	,	PUNCT
dti-1294	113	12	the	the	DET
dti-1294	113	13	macrophage	macrophage	ADJ
dti-1294	113	14	cells	cell	NOUN
dti-1294	113	15	also	also	ADV
dti-1294	113	16	up	up	ADV
dti-1294	113	17	taken	take	VERB
dti-1294	113	18	the	the	DET
dti-1294	113	19	folic	folic	ADJ
dti-1294	113	20	acid	acid	NOUN
dti-1294	113	21	targeted	target	VERB
dti-1294	113	22	liposomal	liposomal	ADJ
dti-1294	113	23	particles	particle	NOUN
dti-1294	113	24	,	,	PUNCT
dti-1294	113	25	then	then	ADV
dti-1294	113	26	free	free	ADJ
dti-1294	113	27	drug	drug	NOUN
dti-1294	113	28	doxorubicin	doxorubicin	PROPN
dti-1294	113	29	drug	drug	NOUN
dti-1294	113	30	target	target	NOUN
dti-1294	113	31	insights	insight	NOUN
dti-1294	113	32	2006	2006	NUM
dti-1294	113	33	:	:	PUNCT
dti-1294	113	34	1	1	NUM
dti-1294	113	35	33	33	NUM
dti-1294	113	36	observation	observation	NOUN
dti-1294	113	37	of	of	ADP
dti-1294	113	38	liposomal	liposomal	ADJ
dti-1294	113	39	drug	drug	NOUN
dti-1294	113	40	particles	particle	NOUN
dti-1294	113	41	penetrating	penetrate	VERB
dti-1294	113	42	into	into	ADP
dti-1294	113	43	solid	solid	ADJ
dti-1294	113	44	tumor	tumor	NOUN
dti-1294	113	45	tissue	tissue	NOUN
dti-1294	113	46	.	.	PUNCT
dti-1294	114	1	released	release	VERB
dti-1294	114	2	out	out	ADP
dti-1294	114	3	after	after	ADP
dti-1294	114	4	the	the	DET
dti-1294	114	5	lipid	lipid	NOUN
dti-1294	114	6	membrane	membrane	NOUN
dti-1294	114	7	broken	break	VERB
dti-1294	114	8	down	down	ADP
dti-1294	114	9	,	,	PUNCT
dti-1294	114	10	which	which	PRON
dti-1294	114	11	killed	kill	VERB
dti-1294	114	12	the	the	DET
dti-1294	114	13	tumor	tumor	NOUN
dti-1294	114	14	cells	cell	NOUN
dti-1294	114	15	in	in	ADP
dti-1294	114	16	neighborhood	neighborhood	NOUN
dti-1294	114	17	as	as	ADV
dti-1294	114	18	well	well	ADV
dti-1294	114	19	.	.	PUNCT
dti-1294	115	1	after	after	SCONJ
dti-1294	115	2	the	the	DET
dti-1294	115	3	cancer	cancer	NOUN
dti-1294	115	4	cells	cell	NOUN
dti-1294	115	5	were	be	AUX
dti-1294	115	6	killed	kill	VERB
dti-1294	115	7	,	,	PUNCT
dti-1294	115	8	the	the	DET
dti-1294	115	9	blood	blood	NOUN
dti-1294	115	10	vessel	vessel	NOUN
dti-1294	115	11	further	far	ADV
dti-1294	115	12	damaged	damage	VERB
dti-1294	115	13	,	,	PUNCT
dti-1294	115	14	we	we	PRON
dti-1294	115	15	saw	see	VERB
dti-1294	115	16	quite	quite	ADV
dti-1294	115	17	often	often	ADV
dti-1294	115	18	the	the	DET
dti-1294	115	19	red	red	ADJ
dti-1294	115	20	blood	blood	NOUN
dti-1294	115	21	cells	cell	NOUN
dti-1294	115	22	presented	present	VERB
dti-1294	115	23	in	in	ADP
dti-1294	115	24	the	the	DET
dti-1294	115	25	damage	damage	NOUN
dti-1294	115	26	tumor	tumor	NOUN
dti-1294	115	27	tissue	tissue	NOUN
dti-1294	115	28	.	.	PUNCT
dti-1294	116	1	in	in	ADP
dti-1294	116	2	this	this	DET
dti-1294	116	3	situation	situation	NOUN
dti-1294	116	4	,	,	PUNCT
dti-1294	116	5	more	more	ADJ
dti-1294	116	6	space	space	NOUN
dti-1294	116	7	and	and	CCONJ
dti-1294	116	8	bigger	big	ADJ
dti-1294	116	9	holes	hole	NOUN
dti-1294	116	10	allowed	allow	VERB
dti-1294	116	11	the	the	DET
dti-1294	116	12	targeted	target	VERB
dti-1294	116	13	liposomal	liposomal	ADJ
dti-1294	116	14	particles	particle	NOUN
dti-1294	116	15	leaked	leak	VERB
dti-1294	116	16	into	into	ADP
dti-1294	116	17	cancer	cancer	NOUN
dti-1294	116	18	tissue	tissue	NOUN
dti-1294	116	19	.	.	PUNCT
dti-1294	117	1	no	no	ADV
dti-1294	117	2	doubt	doubt	ADV
dti-1294	117	3	the	the	DET
dti-1294	117	4	folic	folic	ADJ
dti-1294	117	5	acid	acid	NOUN
dti-1294	117	6	targeted	target	VERB
dti-1294	117	7	liposomal	liposomal	ADJ
dti-1294	117	8	doxorubicin	doxorubicin	PROPN
dti-1294	117	9	showed	show	VERB
dti-1294	117	10	better	well	ADJ
dti-1294	117	11	anticancer	anticancer	NOUN
dti-1294	117	12	effectiveness	effectiveness	NOUN
dti-1294	117	13	compared	compare	VERB
dti-1294	117	14	to	to	ADP
dti-1294	117	15	the	the	DET
dti-1294	117	16	non	non	ADJ
dti-1294	117	17	-	-	ADJ
dti-1294	117	18	targeted	target	VERB
dti-1294	117	19	same	same	ADJ
dti-1294	117	20	liposomal	liposomal	NOUN
dti-1294	117	21	doxorubicin	doxorubicin	PROPN
dti-1294	117	22	.	.	PUNCT
dti-1294	118	1	we	we	PRON
dti-1294	118	2	will	will	AUX
dti-1294	118	3	discuss	discuss	VERB
dti-1294	118	4	about	about	ADP
dti-1294	118	5	this	this	PRON
dti-1294	118	6	in	in	ADP
dti-1294	118	7	another	another	DET
dti-1294	118	8	paper	paper	NOUN
dti-1294	118	9	.	.	PUNCT
dti-1294	119	1	here	here	ADV
dti-1294	119	2	,	,	PUNCT
dti-1294	119	3	we	we	PRON
dti-1294	119	4	need	need	VERB
dti-1294	119	5	to	to	PART
dti-1294	119	6	mention	mention	VERB
dti-1294	119	7	that	that	SCONJ
dti-1294	119	8	since	since	SCONJ
dti-1294	119	9	the	the	DET
dti-1294	119	10	liposomal	liposomal	ADJ
dti-1294	119	11	particles	particle	NOUN
dti-1294	119	12	penetrated	penetrate	VERB
dti-1294	119	13	through	through	ADP
dti-1294	119	14	directly	directly	ADV
dti-1294	119	15	into	into	ADP
dti-1294	119	16	solid	solid	ADJ
dti-1294	119	17	tumor	tumor	NOUN
dti-1294	119	18	the	the	DET
dti-1294	119	19	blood	blood	NOUN
dti-1294	119	20	-	-	PUNCT
dti-1294	119	21	brain	brain	NOUN
dti-1294	119	22	barrier	barrier	NOUN
dti-1294	119	23	will	will	AUX
dti-1294	119	24	no	no	ADV
dti-1294	119	25	longer	long	ADV
dti-1294	119	26	show	show	VERB
dti-1294	119	27	(	(	PUNCT
dti-1294	119	28	vail	vail	PROPN
dti-1294	119	29	et	et	PROPN
dti-1294	119	30	al	al	PROPN
dti-1294	119	31	.	.	PROPN
dti-1294	119	32	2004	2004	NUM
dti-1294	119	33	)	)	PUNCT
dti-1294	119	34	,	,	PUNCT
dti-1294	119	35	which	which	PRON
dti-1294	119	36	will	will	AUX
dti-1294	119	37	be	be	AUX
dti-1294	119	38	good	good	ADJ
dti-1294	119	39	for	for	ADP
dti-1294	119	40	the	the	DET
dti-1294	119	41	treatment	treatment	NOUN
dti-1294	119	42	of	of	ADP
dti-1294	119	43	brain	brain	NOUN
dti-1294	119	44	tumors	tumor	NOUN
dti-1294	119	45	.	.	PUNCT
dti-1294	120	1	but	but	CCONJ
dti-1294	120	2	the	the	DET
dti-1294	120	3	problem	problem	NOUN
dti-1294	120	4	is	be	AUX
dti-1294	120	5	since	since	SCONJ
dti-1294	120	6	the	the	DET
dti-1294	120	7	number	number	NOUN
dti-1294	120	8	of	of	ADP
dti-1294	120	9	liposomal	liposomal	ADJ
dti-1294	120	10	particles	particle	NOUN
dti-1294	120	11	,	,	PUNCT
dti-1294	120	12	in	in	ADP
dti-1294	120	13	another	another	DET
dti-1294	120	14	words	word	NOUN
dti-1294	120	15	the	the	DET
dti-1294	120	16	amount	amount	NOUN
dti-1294	120	17	of	of	ADP
dti-1294	120	18	liposomal	liposomal	ADJ
dti-1294	120	19	drug	drug	NOUN
dti-1294	120	20	which	which	PRON
dti-1294	120	21	can	can	AUX
dti-1294	120	22	leak	leak	VERB
dti-1294	120	23	into	into	ADP
dti-1294	120	24	the	the	DET
dti-1294	120	25	solid	solid	ADJ
dti-1294	120	26	tumor	tumor	NOUN
dti-1294	120	27	is	be	AUX
dti-1294	120	28	determined	determine	VERB
dti-1294	120	29	by	by	ADP
dti-1294	120	30	the	the	DET
dti-1294	120	31	number	number	NOUN
dti-1294	120	32	of	of	ADP
dti-1294	120	33	the	the	DET
dti-1294	120	34	leaking	leak	VERB
dti-1294	120	35	blood	blood	NOUN
dti-1294	120	36	vessels	vessel	NOUN
dti-1294	120	37	,	,	PUNCT
dti-1294	120	38	or	or	CCONJ
dti-1294	120	39	say	say	VERB
dti-1294	120	40	the	the	DET
dti-1294	120	41	nacrosis	nacrosis	ADJ
dti-1294	120	42	level	level	NOUN
dti-1294	120	43	of	of	ADP
dti-1294	120	44	the	the	DET
dti-1294	120	45	solid	solid	ADJ
dti-1294	120	46	cancer	cancer	NOUN
dti-1294	120	47	tissue	tissue	NOUN
dti-1294	120	48	.	.	PUNCT
dti-1294	121	1	so	so	ADV
dti-1294	121	2	,	,	PUNCT
dti-1294	121	3	in	in	ADP
dti-1294	121	4	the	the	DET
dti-1294	121	5	case	case	NOUN
dti-1294	121	6	even	even	ADV
dti-1294	121	7	the	the	DET
dti-1294	121	8	drug	drug	NOUN
dti-1294	121	9	sensitivity	sensitivity	NOUN
dti-1294	121	10	of	of	ADP
dti-1294	121	11	the	the	DET
dti-1294	121	12	cancer	cancer	NOUN
dti-1294	121	13	cells	cell	NOUN
dti-1294	121	14	are	be	AUX
dti-1294	121	15	the	the	DET
dti-1294	121	16	same	same	ADJ
dti-1294	121	17	,	,	PUNCT
dti-1294	121	18	the	the	DET
dti-1294	121	19	effi	effi	PROPN
dti-1294	121	20	ciency	ciency	NOUN
dti-1294	121	21	of	of	ADP
dti-1294	121	22	the	the	DET
dti-1294	121	23	cancer	cancer	NOUN
dti-1294	121	24	treatment	treatment	NOUN
dti-1294	121	25	will	will	AUX
dti-1294	121	26	be	be	AUX
dti-1294	121	27	still	still	ADV
dti-1294	121	28	different	different	ADJ
dti-1294	121	29	at	at	ADP
dti-1294	121	30	least	least	ADJ
dti-1294	121	31	at	at	ADP
dti-1294	121	32	the	the	DET
dti-1294	121	33	beginning	beginning	NOUN
dti-1294	121	34	will	will	AUX
dti-1294	121	35	be	be	AUX
dti-1294	121	36	determined	determine	VERB
dti-1294	121	37	by	by	ADP
dti-1294	121	38	situation	situation	NOUN
dti-1294	121	39	of	of	ADP
dti-1294	121	40	the	the	DET
dti-1294	121	41	blood	blood	NOUN
dti-1294	121	42	vessels	vessel	NOUN
dti-1294	121	43	say	say	VERB
dti-1294	121	44	by	by	ADP
dti-1294	121	45	the	the	DET
dti-1294	121	46	necrotic	necrotic	ADJ
dti-1294	121	47	level	level	NOUN
dti-1294	121	48	of	of	ADP
dti-1294	121	49	the	the	DET
dti-1294	121	50	solid	solid	ADJ
dti-1294	121	51	tumor	tumor	NOUN
dti-1294	121	52	tissue	tissue	NOUN
dti-1294	121	53	.	.	PUNCT
dti-1294	122	1	the	the	DET
dti-1294	122	2	same	same	ADJ
dti-1294	122	3	problem	problem	NOUN
dti-1294	122	4	will	will	AUX
dti-1294	122	5	be	be	AUX
dti-1294	122	6	more	more	ADV
dti-1294	122	7	important	important	ADJ
dti-1294	122	8	for	for	ADP
dti-1294	122	9	the	the	DET
dti-1294	122	10	study	study	NOUN
dti-1294	122	11	on	on	ADP
dti-1294	122	12	early	early	ADJ
dti-1294	122	13	diagnosis	diagnosis	NOUN
dti-1294	122	14	of	of	ADP
dti-1294	122	15	cancer	cancer	NOUN
dti-1294	122	16	,	,	PUNCT
dti-1294	122	17	people	people	NOUN
dti-1294	122	18	nowadays	nowadays	ADV
dti-1294	122	19	are	be	AUX
dti-1294	122	20	trying	try	VERB
dti-1294	122	21	hard	hard	ADV
dti-1294	122	22	to	to	PART
dti-1294	122	23	use	use	VERB
dti-1294	122	24	liposomal	liposomal	ADJ
dti-1294	122	25	particles	particle	NOUN
dti-1294	122	26	or	or	CCONJ
dti-1294	122	27	other	other	ADJ
dti-1294	122	28	nanoparticles	nanoparticle	NOUN
dti-1294	122	29	to	to	PART
dti-1294	122	30	carry	carry	VERB
dti-1294	122	31	special	special	ADJ
dti-1294	122	32	reagents	reagent	NOUN
dti-1294	122	33	or	or	CCONJ
dti-1294	122	34	radio	radio	NOUN
dti-1294	122	35	active	active	ADJ
dti-1294	122	36	labeled	label	VERB
dti-1294	122	37	materials	material	NOUN
dti-1294	122	38	to	to	ADP
dti-1294	122	39	fi	fi	NOUN
dti-1294	122	40	nd	nd	INTJ
dti-1294	122	41	the	the	DET
dti-1294	122	42	location	location	NOUN
dti-1294	122	43	of	of	ADP
dti-1294	122	44	the	the	DET
dti-1294	122	45	earliest	early	ADJ
dti-1294	122	46	stage	stage	NOUN
dti-1294	122	47	tumor	tumor	NOUN
dti-1294	122	48	.	.	PUNCT
dti-1294	123	1	here	here	ADV
dti-1294	123	2	we	we	PRON
dti-1294	123	3	can	can	AUX
dti-1294	123	4	see	see	VERB
dti-1294	123	5	that	that	SCONJ
dti-1294	123	6	we	we	PRON
dti-1294	123	7	need	need	VERB
dti-1294	123	8	to	to	PART
dti-1294	123	9	re	re	VERB
dti-1294	123	10	-	-	VERB
dti-1294	123	11	consider	consider	VERB
dti-1294	123	12	that	that	DET
dti-1294	123	13	strategy	strategy	NOUN
dti-1294	123	14	,	,	PUNCT
dti-1294	123	15	since	since	SCONJ
dti-1294	123	16	with	with	ADP
dti-1294	123	17	that	that	DET
dti-1294	123	18	idea	idea	NOUN
dti-1294	123	19	we	we	PRON
dti-1294	123	20	figure	figure	VERB
dti-1294	123	21	1	1	NUM
dti-1294	123	22	.	.	PUNCT
dti-1294	124	1	the	the	DET
dti-1294	124	2	pegyl	pegyl	ADJ
dti-1294	124	3	-	-	PUNCT
dti-1294	124	4	dspc	dspc	NOUN
dti-1294	124	5	liposomal	liposomal	NOUN
dti-1294	124	6	doxorubicin	doxorubicin	PROPN
dti-1294	124	7	particles	particle	NOUN
dti-1294	124	8	are	be	AUX
dti-1294	124	9	leaking	leak	VERB
dti-1294	124	10	out	out	ADP
dti-1294	124	11	from	from	ADP
dti-1294	124	12	broken	break	VERB
dti-1294	124	13	blood	blood	NOUN
dti-1294	124	14	vessels	vessel	NOUN
dti-1294	124	15	in	in	ADP
dti-1294	124	16	l1210jf	l1210jf	VERB
dti-1294	124	17	solid	solid	ADJ
dti-1294	124	18	tumor	tumor	NOUN
dti-1294	124	19	tissue	tissue	NOUN
dti-1294	124	20	growing	grow	VERB
dti-1294	124	21	subcutaneously	subcutaneously	ADV
dti-1294	124	22	in	in	ADP
dti-1294	124	23	dba2	dba2	PROPN
dti-1294	124	24	mice	mouse	NOUN
dti-1294	124	25	.	.	PUNCT
dti-1294	125	1	photo	photo	NOUN
dti-1294	125	2	a	a	PRON
dti-1294	125	3	&	&	CCONJ
dti-1294	125	4	b	b	PROPN
dti-1294	125	5	samples	sample	NOUN
dti-1294	125	6	were	be	AUX
dti-1294	125	7	collected	collect	VERB
dti-1294	125	8	at	at	ADP
dti-1294	125	9	12	12	NUM
dti-1294	125	10	hours	hour	NOUN
dti-1294	125	11	after	after	SCONJ
dti-1294	125	12	non	non	ADJ
dti-1294	125	13	-	-	ADJ
dti-1294	125	14	targeting	target	VERB
dti-1294	125	15	liposomal	liposomal	ADJ
dti-1294	125	16	doxorubicin	doxorubicin	PROPN
dti-1294	125	17	was	be	AUX
dti-1294	125	18	injected	inject	VERB
dti-1294	125	19	from	from	ADP
dti-1294	125	20	the	the	DET
dti-1294	125	21	tail	tail	NOUN
dti-1294	125	22	vein	vein	NOUN
dti-1294	125	23	;	;	PUNCT
dti-1294	125	24	c	c	PROPN
dti-1294	125	25	&	&	CCONJ
dti-1294	125	26	d	d	PROPN
dti-1294	125	27	samples	sample	NOUN
dti-1294	125	28	were	be	AUX
dti-1294	125	29	taken	take	VERB
dti-1294	125	30	at	at	ADP
dti-1294	125	31	12	12	NUM
dti-1294	125	32	hours	hour	NOUN
dti-1294	125	33	after	after	SCONJ
dti-1294	125	34	folic	folic	ADJ
dti-1294	125	35	acid	acid	NOUN
dti-1294	125	36	targeting	target	VERB
dti-1294	125	37	liposomal	liposomal	ADJ
dti-1294	125	38	doxorubicin	doxorubicin	PROPN
dti-1294	125	39	was	be	AUX
dti-1294	125	40	injected	inject	VERB
dti-1294	125	41	from	from	ADP
dti-1294	125	42	the	the	DET
dti-1294	125	43	tail	tail	NOUN
dti-1294	125	44	vein	vein	NOUN
dti-1294	125	45	.	.	PUNCT
dti-1294	126	1	drug	drug	NOUN
dti-1294	126	2	target	target	NOUN
dti-1294	126	3	insights	insight	NOUN
dti-1294	126	4	2006	2006	NUM
dti-1294	126	5	:	:	PUNCT
dti-1294	126	6	134	134	NUM
dti-1294	126	7	pan	pan	NOUN
dti-1294	126	8	et	et	PROPN
dti-1294	126	9	al	al	PROPN
dti-1294	126	10	may	may	AUX
dti-1294	126	11	not	not	PART
dti-1294	126	12	be	be	AUX
dti-1294	126	13	able	able	ADJ
dti-1294	126	14	to	to	PART
dti-1294	126	15	show	show	VERB
dti-1294	126	16	the	the	DET
dti-1294	126	17	tumor	tumor	NOUN
dti-1294	126	18	location	location	NOUN
dti-1294	126	19	before	before	SCONJ
dti-1294	126	20	the	the	DET
dti-1294	126	21	tumor	tumor	NOUN
dti-1294	126	22	grow	grow	VERB
dti-1294	126	23	into	into	ADP
dti-1294	126	24	special	special	ADJ
dti-1294	126	25	size	size	NOUN
dti-1294	126	26	,	,	PUNCT
dti-1294	126	27	and	and	CCONJ
dti-1294	126	28	the	the	DET
dti-1294	126	29	break	break	NOUN
dti-1294	126	30	blood	blood	NOUN
dti-1294	126	31	vessels	vessel	NOUN
dti-1294	126	32	showed	show	VERB
dti-1294	126	33	up	up	ADP
dti-1294	126	34	.	.	PUNCT
dti-1294	127	1	furthermore	furthermore	ADV
dti-1294	127	2	,	,	PUNCT
dti-1294	127	3	some	some	DET
dti-1294	127	4	cancer	cancer	NOUN
dti-1294	127	5	even	even	ADV
dti-1294	127	6	naturally	naturally	ADV
dti-1294	127	7	do	do	AUX
dti-1294	127	8	not	not	PART
dti-1294	127	9	have	have	VERB
dti-1294	127	10	blood	blood	NOUN
dti-1294	127	11	vessels	vessel	NOUN
dti-1294	127	12	,	,	PUNCT
dti-1294	127	13	such	such	ADJ
dti-1294	127	14	as	as	ADP
dti-1294	127	15	some	some	PRON
dti-1294	127	16	of	of	ADP
dti-1294	127	17	the	the	DET
dti-1294	127	18	non	non	ADJ
dti-1294	127	19	-	-	ADJ
dti-1294	127	20	small	small	ADJ
dti-1294	127	21	-	-	PUNCT
dti-1294	127	22	cell	cell	NOUN
dti-1294	127	23	lung	lung	NOUN
dti-1294	127	24	carcinoma	carcinoma	NOUN
dti-1294	127	25	(	(	PUNCT
dti-1294	127	26	pezzella	pezzella	X
dti-1294	127	27	et	et	PROPN
dti-1294	127	28	al	al	PROPN
dti-1294	127	29	.	.	PROPN
dti-1294	127	30	1997	1997	NUM
dti-1294	127	31	)	)	PUNCT
dti-1294	127	32	.	.	PUNCT
dti-1294	128	1	at	at	ADP
dti-1294	128	2	the	the	DET
dti-1294	128	3	end	end	NOUN
dti-1294	128	4	of	of	ADP
dti-1294	128	5	this	this	DET
dti-1294	128	6	paper	paper	NOUN
dti-1294	128	7	,	,	PUNCT
dti-1294	128	8	we	we	PRON
dti-1294	128	9	would	would	AUX
dti-1294	128	10	like	like	VERB
dti-1294	128	11	to	to	PART
dti-1294	128	12	make	make	VERB
dti-1294	128	13	a	a	DET
dti-1294	128	14	suggestion	suggestion	NOUN
dti-1294	128	15	that	that	SCONJ
dti-1294	128	16	it	it	PRON
dti-1294	128	17	might	might	AUX
dti-1294	128	18	be	be	AUX
dti-1294	128	19	interesting	interesting	ADJ
dti-1294	128	20	,	,	PUNCT
dti-1294	128	21	if	if	SCONJ
dti-1294	128	22	we	we	PRON
dti-1294	128	23	mix	mix	VERB
dti-1294	128	24	the	the	DET
dti-1294	128	25	rhodamine	rhodamine	NOUN
dti-1294	128	26	labeled	label	VERB
dti-1294	128	27	latex	latex	NOUN
dti-1294	128	28	microspheres	microsphere	VERB
dti-1294	128	29	with	with	ADP
dti-1294	128	30	an	an	DET
dti-1294	128	31	anticancer	anticancer	NOUN
dti-1294	128	32	drug	drug	NOUN
dti-1294	128	33	sample	sample	NOUN
dti-1294	128	34	,	,	PUNCT
dti-1294	128	35	or	or	CCONJ
dti-1294	128	36	a	a	DET
dti-1294	128	37	liposomal	liposomal	ADJ
dti-1294	128	38	form	form	NOUN
dti-1294	128	39	drog	drog	NOUN
dti-1294	128	40	suspension	suspension	NOUN
dti-1294	128	41	,	,	PUNCT
dti-1294	128	42	we	we	PRON
dti-1294	128	43	may	may	AUX
dti-1294	128	44	be	be	AUX
dti-1294	128	45	able	able	ADJ
dti-1294	128	46	to	to	PART
dti-1294	128	47	trace	trace	VERB
dti-1294	128	48	the	the	DET
dti-1294	128	49	drug	drug	NOUN
dti-1294	128	50	penetration	penetration	NOUN
dti-1294	128	51	process	process	NOUN
dti-1294	128	52	in	in	ADP
dti-1294	128	53	a	a	DET
dti-1294	128	54	solid	solid	ADJ
dti-1294	128	55	tumor	tumor	NOUN
dti-1294	128	56	tissue	tissue	NOUN
dti-1294	128	57	,	,	PUNCT
dti-1294	128	58	not	not	PART
dti-1294	128	59	like	like	ADP
dti-1294	128	60	doxorubicin	doxorubicin	VERB
dti-1294	128	61	its	its	PRON
dti-1294	128	62	fl	fl	PROPN
dti-1294	128	63	uorescence	uorescence	NOUN
dti-1294	128	64	will	will	AUX
dti-1294	128	65	be	be	AUX
dti-1294	128	66	diminished	diminish	VERB
dti-1294	128	67	after	after	SCONJ
dti-1294	128	68	doxorubicin	doxorubicin	PROPN
dti-1294	128	69	reacted	react	VERB
dti-1294	128	70	to	to	ADP
dti-1294	128	71	the	the	DET
dti-1294	128	72	cells	cell	NOUN
dti-1294	128	73	,	,	PUNCT
dti-1294	128	74	the	the	DET
dti-1294	128	75	fl	fl	PROPN
dti-1294	128	76	uorescence	uorescence	NOUN
dti-1294	128	77	of	of	ADP
dti-1294	128	78	rhodamine	rhodamine	NOUN
dti-1294	128	79	can	can	AUX
dti-1294	128	80	last	last	VERB
dti-1294	128	81	much	much	ADV
dti-1294	128	82	longer	long	ADV
dti-1294	128	83	.	.	PUNCT
dti-1294	129	1	acknowledgements	acknowledgement	NOUN
dti-1294	129	2	the	the	DET
dti-1294	129	3	authors	author	NOUN
dti-1294	129	4	are	be	AUX
dti-1294	129	5	grateful	grateful	ADJ
dti-1294	129	6	to	to	ADP
dti-1294	129	7	dr	dr	PROPN
dti-1294	129	8	.	.	PROPN
dti-1294	129	9	robert	robert	PROPN
dti-1294	129	10	j	j	PROPN
dti-1294	129	11	lee	lee	PROPN
dti-1294	129	12	and	and	CCONJ
dti-1294	129	13	dr	dr	PROPN
dti-1294	129	14	.	.	PROPN
dti-1294	129	15	julius	julius	PROPN
dti-1294	129	16	kreier	kreier	PROPN
dti-1294	129	17	for	for	ADP
dti-1294	129	18	their	their	PRON
dti-1294	129	19	creative	creative	ADJ
dti-1294	129	20	discussion	discussion	NOUN
dti-1294	129	21	and	and	CCONJ
dti-1294	129	22	encouragements	encouragement	NOUN
dti-1294	129	23	.	.	PUNCT
dti-1294	130	1	the	the	DET
dti-1294	130	2	authors	author	NOUN
dti-1294	130	3	would	would	AUX
dti-1294	130	4	also	also	ADV
dti-1294	130	5	like	like	VERB
dti-1294	130	6	to	to	PART
dti-1294	130	7	express	express	VERB
dti-1294	130	8	our	our	PRON
dti-1294	130	9	thanks	thank	NOUN
dti-1294	130	10	to	to	ADP
dti-1294	130	11	mr	mr	PROPN
dti-1294	130	12	.	.	PROPN
dti-1294	130	13	brian	brian	PROPN
dti-1294	130	14	kemmenoe	kemmenoe	PROPN
dti-1294	130	15	of	of	ADP
dti-1294	130	16	ohio	ohio	PROPN
dti-1294	130	17	state	state	PROPN
dti-1294	130	18	university	university	PROPN
dti-1294	130	19	campus	campus	NOUN
dti-1294	130	20	microscopy	microscopy	NOUN
dti-1294	130	21	&	&	CCONJ
dti-1294	130	22	imaging	imaging	PROPN
dti-1294	130	23	core	core	NOUN
dti-1294	130	24	for	for	ADP
dti-1294	130	25	his	his	PRON
dti-1294	130	26	technical	technical	ADJ
dti-1294	130	27	help	help	NOUN
dti-1294	130	28	.	.	PUNCT
dti-1294	131	1	references	reference	NOUN
dti-1294	131	2	dvorak	dvorak	PROPN
dti-1294	131	3	,	,	PUNCT
dti-1294	131	4	h.f	h.f	PROPN
dti-1294	131	5	.	.	PROPN
dti-1294	131	6	,	,	PUNCT
dti-1294	131	7	nagy	nagy	PROPN
dti-1294	131	8	,	,	PUNCT
dti-1294	131	9	j.a	j.a	PROPN
dti-1294	131	10	.	.	PROPN
dti-1294	131	11	and	and	CCONJ
dti-1294	131	12	feng	feng	PROPN
dti-1294	131	13	,	,	PUNCT
dti-1294	131	14	d.	d.	PROPN
dti-1294	131	15	et	et	PROPN
dti-1294	131	16	al	al	PROPN
dti-1294	131	17	.	.	PROPN
dti-1294	131	18	1999	1999	NUM
dti-1294	131	19	.	.	PUNCT
dti-1294	132	1	vascular	vascular	ADJ
dti-1294	132	2	permeability	permeability	NOUN
dti-1294	132	3	factor	factor	NOUN
dti-1294	132	4	/	/	SYM
dti-1294	132	5	vascular	vascular	ADJ
dti-1294	132	6	endothelial	endothelial	ADJ
dti-1294	132	7	growth	growth	NOUN
dti-1294	132	8	factor	factor	NOUN
dti-1294	132	9	and	and	CCONJ
dti-1294	132	10	the	the	DET
dti-1294	132	11	signifi	signifi	NOUN
dti-1294	132	12	cance	cance	NOUN
dti-1294	132	13	of	of	ADP
dti-1294	132	14	microvascular	microvascular	ADJ
dti-1294	132	15	hyperpermeability	hyperpermeability	NOUN
dti-1294	132	16	in	in	ADP
dti-1294	132	17	angiogenesis	angiogenesis	NOUN
dti-1294	132	18	.	.	PUNCT
dti-1294	133	1	curr	curr	PROPN
dti-1294	133	2	.	.	PUNCT
dti-1294	133	3	top	top	PROPN
dti-1294	133	4	.	.	PUNCT
dti-1294	134	1	microbiol	microbiol	PROPN
dti-1294	134	2	.	.	PUNCT
dti-1294	135	1	immunol	immunol	PROPN
dti-1294	135	2	.	.	PROPN
dti-1294	135	3	,	,	PUNCT
dti-1294	135	4	237:97–132	237:97–132	NUM
dti-1294	135	5	.	.	PUNCT
dti-1294	136	1	forssn	forssn	PROPN
dti-1294	136	2	,	,	PUNCT
dti-1294	136	3	e.a	e.a	PROPN
dti-1294	136	4	.	.	PROPN
dti-1294	136	5	,	,	PUNCT
dti-1294	136	6	male	male	NOUN
dti-1294	136	7	-	-	PUNCT
dti-1294	136	8	brune	brune	NOUN
dti-1294	136	9	,	,	PUNCT
dti-1294	136	10	r.	r.	PROPN
dti-1294	136	11	and	and	CCONJ
dti-1294	136	12	adler	adler	PROPN
dti-1294	136	13	-	-	PUNCT
dti-1294	136	14	moore	moore	PROPN
dti-1294	136	15	,	,	PUNCT
dti-1294	136	16	j.p	j.p	PROPN
dti-1294	136	17	.	.	PROPN
dti-1294	136	18	et	et	PROPN
dti-1294	136	19	al	al	PROPN
dti-1294	136	20	.	.	PROPN
dti-1294	136	21	1996	1996	NUM
dti-1294	136	22	.	.	PUNCT
dti-1294	137	1	fluorescence	fluorescence	PROPN
dti-1294	137	2	imaging	imaging	NOUN
dti-1294	137	3	studies	study	NOUN
dti-1294	137	4	for	for	ADP
dti-1294	137	5	the	the	DET
dti-1294	137	6	disposition	disposition	NOUN
dti-1294	137	7	of	of	ADP
dti-1294	137	8	daunorubicin	daunorubicin	PROPN
dti-1294	137	9	liposomes	liposome	NOUN
dti-1294	137	10	(	(	PUNCT
dti-1294	137	11	daunoxome	daunoxome	NOUN
dti-1294	137	12	)	)	PUNCT
dti-1294	137	13	within	within	ADP
dti-1294	137	14	tumor	tumor	NOUN
dti-1294	137	15	tissue	tissue	NOUN
dti-1294	137	16	.	.	PUNCT
dti-1294	138	1	cancer	cancer	NOUN
dti-1294	138	2	res	re	NOUN
dti-1294	138	3	.	.	PUNCT
dti-1294	138	4	,	,	PUNCT
dti-1294	139	1	56:2066–2075	56:2066–2075	NUM
dti-1294	139	2	.	.	PUNCT
dti-1294	140	1	hashizume	hashizume	PROPN
dti-1294	140	2	,	,	PUNCT
dti-1294	140	3	h.	h.	PROPN
dti-1294	140	4	,	,	PUNCT
dti-1294	140	5	baluk	baluk	PROPN
dti-1294	140	6	,	,	PUNCT
dti-1294	140	7	p.	p.	NOUN
dti-1294	140	8	and	and	CCONJ
dti-1294	140	9	morikawa	morikawa	PROPN
dti-1294	140	10	,	,	PUNCT
dti-1294	140	11	s.	s.	PROPN
dti-1294	140	12	et	et	PROPN
dti-1294	140	13	al	al	PROPN
dti-1294	140	14	.	.	PROPN
dti-1294	140	15	2000	2000	NUM
dti-1294	140	16	.	.	PUNCT
dti-1294	141	1	openings	opening	NOUN
dti-1294	141	2	between	between	ADP
dti-1294	141	3	defective	defective	ADJ
dti-1294	141	4	endothelial	endothelial	ADJ
dti-1294	141	5	cells	cell	NOUN
dti-1294	141	6	explain	explain	VERB
dti-1294	141	7	tumor	tumor	NOUN
dti-1294	141	8	vessel	vessel	NOUN
dti-1294	141	9	leakiness	leakiness	NOUN
dti-1294	141	10	.	.	PUNCT
dti-1294	142	1	am	be	AUX
dti-1294	142	2	.	.	PUNCT
dti-1294	143	1	soc	soc	PROPN
dti-1294	143	2	.	.	PUNCT
dti-1294	144	1	invest	invest	VERB
dti-1294	144	2	.	.	PUNCT
dti-1294	145	1	pathol	pathol	PROPN
dti-1294	145	2	.	.	PROPN
dti-1294	145	3	,	,	PUNCT
dti-1294	145	4	156:1363–1380	156:1363–1380	PROPN
dti-1294	146	1	.	.	PUNCT
dti-1294	146	2	ishida	ishida	PROPN
dti-1294	146	3	,	,	PUNCT
dti-1294	146	4	o.	o.	PROPN
dti-1294	146	5	,	,	PUNCT
dti-1294	146	6	maruyama	maruyama	PROPN
dti-1294	146	7	,	,	PUNCT
dti-1294	146	8	k.	k.	PROPN
dti-1294	146	9	and	and	CCONJ
dti-1294	146	10	sasaki	sasaki	PROPN
dti-1294	146	11	,	,	PUNCT
dti-1294	146	12	k.	k.	PROPN
dti-1294	146	13	et	et	PROPN
dti-1294	147	1	al	al	PROPN
dti-1294	147	2	.	.	PROPN
dti-1294	147	3	1999	1999	NUM
dti-1294	147	4	.	.	PUNCT
dti-1294	148	1	size	size	NOUN
dti-1294	148	2	-	-	PUNCT
dti-1294	148	3	dependent	dependent	ADJ
dti-1294	148	4	extravasation	extravasation	NOUN
dti-1294	148	5	and	and	CCONJ
dti-1294	148	6	interstitial	interstitial	ADJ
dti-1294	148	7	location	location	NOUN
dti-1294	148	8	of	of	ADP
dti-1294	148	9	polyethyleneglycol	polyethyleneglycol	NOUN
dti-1294	148	10	liposomes	liposome	NOUN
dti-1294	148	11	in	in	ADP
dti-1294	148	12	solid	solid	ADJ
dti-1294	148	13	tumor	tumor	NOUN
dti-1294	148	14	-	-	PUNCT
dti-1294	148	15	bearing	bear	VERB
dti-1294	148	16	mice	mouse	NOUN
dti-1294	148	17	.	.	PUNCT
dti-1294	149	1	international	international	ADJ
dti-1294	149	2	j.	j.	PROPN
dti-1294	149	3	pharmaceutics	pharmaceutics	PROPN
dti-1294	149	4	,	,	PUNCT
dti-1294	149	5	100:49–56	100:49–56	NUM
dti-1294	149	6	.	.	PUNCT
dti-1294	149	7	jain	jain	PROPN
dti-1294	149	8	,	,	PUNCT
dti-1294	149	9	r.k	r.k	PROPN
dti-1294	149	10	.	.	PROPN
dti-1294	149	11	2001	2001	NUM
dti-1294	149	12	.	.	PUNCT
dti-1294	150	1	delivery	delivery	NOUN
dti-1294	150	2	of	of	ADP
dti-1294	150	3	molecular	molecular	ADJ
dti-1294	150	4	medicine	medicine	NOUN
dti-1294	150	5	to	to	ADP
dti-1294	150	6	solid	solid	ADJ
dti-1294	150	7	tumors	tumor	NOUN
dti-1294	150	8	:	:	PUNCT
dti-1294	150	9	lessons	lesson	NOUN
dti-1294	150	10	from	from	ADP
dti-1294	150	11	in	in	ADP
dti-1294	150	12	vivo	vivo	ADJ
dti-1294	150	13	imaging	imaging	NOUN
dti-1294	150	14	of	of	ADP
dti-1294	150	15	gene	gene	NOUN
dti-1294	150	16	expression	expression	NOUN
dti-1294	150	17	and	and	CCONJ
dti-1294	150	18	function	function	NOUN
dti-1294	150	19	.	.	PUNCT
dti-1294	151	1	j.	j.	PROPN
dti-1294	151	2	control	control	PROPN
dti-1294	151	3	release	release	PROPN
dti-1294	151	4	,	,	PUNCT
dti-1294	151	5	74:7–25	74:7–25	X
dti-1294	151	6	.	.	PUNCT
dti-1294	151	7	kirpotin	kirpotin	PROPN
dti-1294	151	8	,	,	PUNCT
dti-1294	151	9	d.b	d.b	PROPN
dti-1294	151	10	.	.	PROPN
dti-1294	151	11	,	,	PUNCT
dti-1294	151	12	drummond	drummond	PROPN
dti-1294	151	13	,	,	PUNCT
dti-1294	151	14	d.c	d.c	PROPN
dti-1294	151	15	.	.	PROPN
dti-1294	151	16	and	and	CCONJ
dti-1294	151	17	shao	shao	PROPN
dti-1294	151	18	,	,	PUNCT
dti-1294	151	19	y.	y.	PROPN
dti-1294	151	20	et	et	PROPN
dti-1294	151	21	al	al	PROPN
dti-1294	151	22	.	.	PROPN
dti-1294	151	23	2006	2006	NUM
dti-1294	151	24	.	.	PUNCT
dti-1294	152	1	antibody	antibody	NOUN
dti-1294	152	2	targeting	target	VERB
dti-1294	152	3	of	of	ADP
dti-1294	152	4	long	long	ADV
dti-1294	152	5	-	-	PUNCT
dti-1294	152	6	circulating	circulate	VERB
dti-1294	152	7	lipidic	lipidic	ADJ
dti-1294	152	8	nanoparticles	nanoparticle	NOUN
dti-1294	152	9	does	do	AUX
dti-1294	152	10	not	not	PART
dti-1294	152	11	increase	increase	VERB
dti-1294	152	12	tumor	tumor	NOUN
dti-1294	152	13	localization	localization	NOUN
dti-1294	152	14	but	but	CCONJ
dti-1294	152	15	does	do	AUX
dti-1294	152	16	increase	increase	VERB
dti-1294	152	17	internalization	internalization	NOUN
dti-1294	152	18	in	in	ADP
dti-1294	152	19	animal	animal	NOUN
dti-1294	152	20	models	model	NOUN
dti-1294	152	21	.	.	PUNCT
dti-1294	153	1	cancer	cancer	NOUN
dti-1294	153	2	res	re	NOUN
dti-1294	153	3	.	.	PROPN
dti-1294	153	4	,	,	PUNCT
dti-1294	154	1	66:6732–6740	66:6732–6740	NUM
dti-1294	154	2	.	.	PUNCT
dti-1294	155	1	kohn	kohn	PROPN
dti-1294	155	2	,	,	PUNCT
dti-1294	155	3	s.	s.	PROPN
dti-1294	155	4	,	,	PUNCT
dti-1294	155	5	nagy	nagy	PROPN
dti-1294	155	6	,	,	PUNCT
dti-1294	155	7	j.a	j.a	PROPN
dti-1294	155	8	.	.	PROPN
dti-1294	155	9	and	and	CCONJ
dti-1294	155	10	dvorak	dvorak	PROPN
dti-1294	155	11	,	,	PUNCT
dti-1294	155	12	h.f	h.f	PROPN
dti-1294	155	13	.	.	PROPN
dti-1294	155	14	1992	1992	NUM
dti-1294	155	15	.	.	PUNCT
dti-1294	156	1	pathways	pathway	NOUN
dti-1294	156	2	of	of	ADP
dti-1294	156	3	macromolecular	macromolecular	ADJ
dti-1294	156	4	tracer	tracer	NOUN
dti-1294	156	5	transport	transport	NOUN
dti-1294	156	6	across	across	ADP
dti-1294	156	7	venules	venule	NOUN
dti-1294	156	8	and	and	CCONJ
dti-1294	156	9	small	small	ADJ
dti-1294	156	10	veins	vein	NOUN
dti-1294	156	11	:	:	PUNCT
dti-1294	156	12	structural	structural	ADJ
dti-1294	156	13	basis	basis	NOUN
dti-1294	156	14	for	for	ADP
dti-1294	156	15	the	the	DET
dti-1294	156	16	hyperpermeability	hyperpermeability	NOUN
dti-1294	156	17	of	of	ADP
dti-1294	156	18	tumor	tumor	NOUN
dti-1294	156	19	blood	blood	NOUN
dti-1294	156	20	vessels	vessel	NOUN
dti-1294	156	21	.	.	PUNCT
dti-1294	157	1	lab	lab	NOUN
dti-1294	157	2	invest	invest	PROPN
dti-1294	157	3	.	.	PUNCT
dti-1294	157	4	,	,	PUNCT
dti-1294	157	5	67:596	67:596	NUM
dti-1294	157	6	–	–	PUNCT
dti-1294	157	7	607	607	NUM
dti-1294	157	8	.	.	PUNCT
dti-1294	158	1	lichtenbeld	lichtenbeld	VERB
dti-1294	158	2	,	,	PUNCT
dti-1294	158	3	h.c	h.c	PROPN
dti-1294	158	4	.	.	PROPN
dti-1294	158	5	,	,	PUNCT
dti-1294	158	6	yuan	yuan	PROPN
dti-1294	158	7	,	,	PUNCT
dti-1294	158	8	f.	f.	PROPN
dti-1294	158	9	and	and	CCONJ
dti-1294	158	10	michel	michel	PROPN
dti-1294	158	11	,	,	PUNCT
dti-1294	158	12	c.c	c.c	PROPN
dti-1294	158	13	.	.	PROPN
dti-1294	158	14	1996	1996	NUM
dti-1294	158	15	.	.	PUNCT
dti-1294	159	1	perfusion	perfusion	NOUN
dti-1294	159	2	of	of	ADP
dti-1294	159	3	single	single	ADJ
dti-1294	159	4	tumor	tumor	NOUN
dti-1294	159	5	microvessels	microvessel	NOUN
dti-1294	159	6	:	:	PUNCT
dti-1294	159	7	application	application	NOUN
dti-1294	159	8	to	to	PART
dti-1294	159	9	vascular	vascular	VERB
dti-1294	159	10	permeability	permeability	NOUN
dti-1294	159	11	measurement	measurement	NOUN
dti-1294	159	12	.	.	PUNCT
dti-1294	160	1	microcirculation	microcirculation	NOUN
dti-1294	160	2	,	,	PUNCT
dti-1294	160	3	3:349–357	3:349–357	NUM
dti-1294	160	4	.	.	PUNCT
dti-1294	161	1	murdoch	murdoch	PROPN
dti-1294	161	2	,	,	PUNCT
dti-1294	161	3	c.	c.	PROPN
dti-1294	161	4	,	,	PUNCT
dti-1294	161	5	giannoudis	giannoudis	VERB
dti-1294	161	6	,	,	PUNCT
dti-1294	161	7	a.	a.	NOUN
dti-1294	161	8	and	and	CCONJ
dti-1294	161	9	lewis	lewis	PROPN
dti-1294	161	10	,	,	PUNCT
dti-1294	161	11	c.e	c.e	PROPN
dti-1294	161	12	.	.	PROPN
dti-1294	161	13	2004	2004	NUM
dti-1294	161	14	.	.	PUNCT
dti-1294	162	1	mechanisms	mechanism	NOUN
dti-1294	162	2	regulating	regulate	VERB
dti-1294	162	3	the	the	DET
dti-1294	162	4	recruitment	recruitment	NOUN
dti-1294	162	5	of	of	ADP
dti-1294	162	6	macrophages	macrophage	NOUN
dti-1294	162	7	into	into	ADP
dti-1294	162	8	hypoxic	hypoxic	ADJ
dti-1294	162	9	areas	area	NOUN
dti-1294	162	10	of	of	ADP
dti-1294	162	11	tumors	tumor	NOUN
dti-1294	162	12	and	and	CCONJ
dti-1294	162	13	other	other	ADJ
dti-1294	162	14	ischemic	ischemic	ADJ
dti-1294	162	15	tissues	tissue	NOUN
dti-1294	162	16	.	.	PUNCT
dti-1294	163	1	blood	blood	NOUN
dti-1294	163	2	,	,	PUNCT
dti-1294	163	3	104:2224–2234	104:2224–2234	NUM
dti-1294	163	4	.	.	PUNCT
dti-1294	164	1	nagayasu	nagayasu	PROPN
dti-1294	164	2	,	,	PUNCT
dti-1294	164	3	a.	a.	NOUN
dti-1294	164	4	,	,	PUNCT
dti-1294	164	5	uchiyama	uchiyama	NOUN
dti-1294	164	6	,	,	PUNCT
dti-1294	164	7	k.	k.	PROPN
dti-1294	164	8	and	and	CCONJ
dti-1294	164	9	kiwada	kiwada	PROPN
dti-1294	164	10	,	,	PUNCT
dti-1294	164	11	h.	h.	PROPN
dti-1294	164	12	1999	1999	NUM
dti-1294	164	13	.	.	PUNCT
dti-1294	165	1	the	the	DET
dti-1294	165	2	size	size	NOUN
dti-1294	165	3	of	of	ADP
dti-1294	165	4	liposomes	liposome	NOUN
dti-1294	165	5	:	:	PUNCT
dti-1294	165	6	a	a	DET
dti-1294	165	7	factor	factor	NOUN
dti-1294	165	8	which	which	PRON
dti-1294	165	9	affects	affect	VERB
dti-1294	165	10	their	their	PRON
dti-1294	165	11	targeting	target	VERB
dti-1294	165	12	effi	effi	PROPN
dti-1294	165	13	ciency	ciency	NOUN
dti-1294	165	14	to	to	ADP
dti-1294	165	15	tumors	tumor	NOUN
dti-1294	165	16	and	and	CCONJ
dti-1294	165	17	therapeutic	therapeutic	ADJ
dti-1294	165	18	activity	activity	NOUN
dti-1294	165	19	of	of	ADP
dti-1294	165	20	liposomal	liposomal	ADJ
dti-1294	165	21	antitumor	antitumor	PROPN
dti-1294	165	22	drugs	drug	NOUN
dti-1294	165	23	.	.	PUNCT
dti-1294	166	1	adv	adv	PROPN
dti-1294	166	2	.	.	PUNCT
dti-1294	166	3	drug	drug	PROPN
dti-1294	166	4	delivery	delivery	NOUN
dti-1294	166	5	rev	rev	VERB
dti-1294	166	6	.	.	PROPN
dti-1294	166	7	,	,	PUNCT
dti-1294	166	8	40:75–87	40:75–87	PROPN
dti-1294	166	9	.	.	PUNCT
dti-1294	167	1	pan	pan	PROPN
dti-1294	167	2	,	,	PUNCT
dti-1294	167	3	x.q	x.q	PROPN
dti-1294	167	4	.	.	PROPN
dti-1294	167	5	,	,	PUNCT
dti-1294	167	6	zheng	zheng	PROPN
dti-1294	167	7	,	,	PUNCT
dti-1294	167	8	x.	x.	PROPN
dti-1294	167	9	and	and	CCONJ
dti-1294	167	10	shi	shi	PROPN
dti-1294	167	11	,	,	PUNCT
dti-1294	167	12	g.f	g.f	PROPN
dti-1294	167	13	.	.	PROPN
dti-1294	167	14	2002	2002	NUM
dti-1294	167	15	.	.	PUNCT
dti-1294	168	1	strategy	strategy	NOUN
dti-1294	168	2	for	for	ADP
dti-1294	168	3	the	the	DET
dti-1294	168	4	treatment	treatment	NOUN
dti-1294	168	5	of	of	ADP
dti-1294	168	6	acute	acute	ADJ
dti-1294	168	7	myelogenous	myelogenous	ADJ
dti-1294	168	8	leukemia	leukemia	NOUN
dti-1294	168	9	based	base	VERB
dti-1294	168	10	on	on	ADP
dti-1294	168	11	folate	folate	NOUN
dti-1294	168	12	receptor	receptor	NOUN
dti-1294	168	13	-	-	PUNCT
dti-1294	168	14	targeted	target	VERB
dti-1294	168	15	liposomal	liposomal	ADJ
dti-1294	168	16	doxorubicin	doxorubicin	PROPN
dti-1294	168	17	combined	combine	VERB
dti-1294	168	18	with	with	ADP
dti-1294	168	19	receptor	receptor	NOUN
dti-1294	168	20	induction	induction	NOUN
dti-1294	168	21	using	use	VERB
dti-1294	168	22	all	all	PRON
dti-1294	168	23	-	-	PUNCT
dti-1294	168	24	trans	trans	PROPN
dti-1294	168	25	retinoic	retinoic	PROPN
dti-1294	168	26	acid	acid	NOUN
dti-1294	168	27	.	.	PUNCT
dti-1294	169	1	blood	blood	NOUN
dti-1294	169	2	,	,	PUNCT
dti-1294	169	3	100:594–602	100:594–602	NUM
dti-1294	169	4	.	.	PUNCT
dti-1294	170	1	pan	pan	PROPN
dti-1294	170	2	,	,	PUNCT
dti-1294	170	3	x.q	x.q	PROPN
dti-1294	170	4	.	.	PROPN
dti-1294	170	5	,	,	PUNCT
dti-1294	170	6	wang	wang	PROPN
dti-1294	170	7	,	,	PUNCT
dti-1294	170	8	h.	h.	PROPN
dti-1294	170	9	and	and	CCONJ
dti-1294	170	10	lee	lee	PROPN
dti-1294	170	11	,	,	PUNCT
dti-1294	170	12	r.j	r.j	PROPN
dti-1294	170	13	.	.	PROPN
dti-1294	170	14	2003	2003	NUM
dti-1294	170	15	.	.	PUNCT
dti-1294	171	1	antitumor	antitumor	NOUN
dti-1294	171	2	activity	activity	NOUN
dti-1294	171	3	of	of	ADP
dti-1294	171	4	folate	folate	NOUN
dti-1294	171	5	receptor	receptor	NOUN
dti-1294	171	6	-	-	PUNCT
dti-1294	171	7	targeted	target	VERB
dti-1294	171	8	liposomal	liposomal	ADJ
dti-1294	171	9	doxorubicin	doxorubicin	PROPN
dti-1294	171	10	in	in	ADP
dti-1294	171	11	a	a	DET
dti-1294	171	12	kb	kb	PROPN
dti-1294	171	13	oral	oral	ADJ
dti-1294	171	14	carcinoma	carcinoma	NOUN
dti-1294	171	15	murine	murine	ADJ
dti-1294	171	16	xenograft	xenograft	PROPN
dti-1294	171	17	model	model	PROPN
dti-1294	171	18	.	.	PUNCT
dti-1294	172	1	pharmaceutical	pharmaceutical	NOUN
dti-1294	172	2	res	re	NOUN
dti-1294	172	3	.	.	PROPN
dti-1294	172	4	,	,	PUNCT
dti-1294	173	1	20:417–422	20:417–422	NUM
dti-1294	173	2	.	.	PUNCT
dti-1294	174	1	pan	pan	PROPN
dti-1294	174	2	,	,	PUNCT
dti-1294	174	3	x.q	x.q	PROPN
dti-1294	174	4	.	.	PROPN
dti-1294	174	5	,	,	PUNCT
dti-1294	174	6	lee	lee	PROPN
dti-1294	174	7	,	,	PUNCT
dti-1294	174	8	r.j	r.j	PROPN
dti-1294	174	9	.	.	PROPN
dti-1294	174	10	and	and	CCONJ
dti-1294	174	11	ratnam	ratnam	PROPN
dti-1294	174	12	,	,	PUNCT
dti-1294	174	13	m.	m.	NOUN
dti-1294	174	14	2004a	2004a	NUM
dti-1294	174	15	.	.	PUNCT
dti-1294	175	1	penetration	penetration	NOUN
dti-1294	175	2	into	into	ADP
dti-1294	175	3	solid	solid	ADJ
dti-1294	175	4	tumor	tumor	NOUN
dti-1294	175	5	tissue	tissue	NOUN
dti-1294	175	6	of	of	ADP
dti-1294	175	7	fl	fl	PRON
dti-1294	175	8	uorescent	uorescent	ADJ
dti-1294	175	9	latex	latex	NOUN
dti-1294	175	10	microspheres	microsphere	NOUN
dti-1294	175	11	:	:	PUNCT
dti-1294	175	12	a	a	DET
dti-1294	175	13	mimic	mimic	NOUN
dti-1294	175	14	of	of	ADP
dti-1294	175	15	liposome	liposome	NOUN
dti-1294	175	16	particles	particle	NOUN
dti-1294	175	17	.	.	PUNCT
dti-1294	176	1	anticancer	anticancer	NOUN
dti-1294	176	2	res	re	NOUN
dti-1294	176	3	.	.	PROPN
dti-1294	176	4	,	,	PUNCT
dti-1294	177	1	24:3005–3008	24:3005–3008	PROPN
dti-1294	177	2	.	.	PUNCT
dti-1294	177	3	patel	patel	PROPN
dti-1294	177	4	,	,	PUNCT
dti-1294	177	5	j.	j.	PROPN
dti-1294	177	6	1996	1996	NUM
dti-1294	177	7	.	.	PUNCT
dti-1294	178	1	liposomal	liposomal	PROPN
dti-1294	178	2	doxorubicin	doxorubicin	PROPN
dti-1294	178	3	:	:	PUNCT
dti-1294	178	4	doxil	doxil	PROPN
dti-1294	178	5	.	.	PUNCT
dti-1294	179	1	j.	j.	PROPN
dti-1294	179	2	oncol	oncol	PROPN
dti-1294	179	3	.	.	PUNCT
dti-1294	180	1	practice	practice	NOUN
dti-1294	180	2	,	,	PUNCT
dti-1294	180	3	2:201–210	2:201–210	NUM
dti-1294	180	4	.	.	PUNCT
dti-1294	181	1	pezzella	pezzella	PROPN
dti-1294	181	2	,	,	PUNCT
dti-1294	181	3	f.	f.	PROPN
dti-1294	181	4	,	,	PUNCT
dti-1294	181	5	pastorino	pastorino	PROPN
dti-1294	181	6	,	,	PUNCT
dti-1294	181	7	u.	u.	PROPN
dti-1294	181	8	and	and	CCONJ
dti-1294	181	9	tagliabue	tagliabue	PROPN
dti-1294	181	10	,	,	PUNCT
dti-1294	181	11	e.	e.	PROPN
dti-1294	181	12	et	et	PROPN
dti-1294	181	13	al	al	PROPN
dti-1294	181	14	.	.	PROPN
dti-1294	181	15	1997	1997	NUM
dti-1294	181	16	.	.	PUNCT
dti-1294	182	1	non	non	ADJ
dti-1294	182	2	-	-	ADJ
dti-1294	182	3	small	small	ADJ
dti-1294	182	4	-	-	PUNCT
dti-1294	182	5	cell	cell	NOUN
dti-1294	182	6	lung	lung	NOUN
dti-1294	182	7	carcinoma	carcinoma	NOUN
dti-1294	182	8	growth	growth	NOUN
dti-1294	182	9	without	without	ADP
dti-1294	182	10	morphological	morphological	ADJ
dti-1294	182	11	evidence	evidence	NOUN
dti-1294	182	12	of	of	ADP
dti-1294	182	13	neoangiogenesis	neoangiogenesis	NOUN
dti-1294	182	14	.	.	PUNCT
dti-1294	183	1	american	american	PROPN
dti-1294	183	2	j.	j.	PROPN
dti-1294	183	3	pathol	pathol	PROPN
dti-1294	183	4	.	.	PROPN
dti-1294	183	5	,	,	PUNCT
dti-1294	183	6	151:1417–1423	151:1417–1423	NUM
dti-1294	183	7	.	.	PUNCT
dti-1294	183	8	rogatsch	rogatsch	PROPN
dti-1294	183	9	,	,	PUNCT
dti-1294	183	10	h.	h.	PROPN
dti-1294	183	11	,	,	PUNCT
dti-1294	183	12	hittmair	hittmair	NOUN
dti-1294	183	13	,	,	PUNCT
dti-1294	183	14	a.	a.	NOUN
dti-1294	183	15	and	and	CCONJ
dti-1294	183	16	reissigl	reissigl	PROPN
dti-1294	183	17	,	,	PUNCT
dti-1294	183	18	a.	a.	PROPN
dti-1294	183	19	et	et	PROPN
dti-1294	183	20	al	al	PROPN
dti-1294	183	21	.	.	PROPN
dti-1294	183	22	1997	1997	NUM
dti-1294	183	23	.	.	PUNCT
dti-1294	184	1	microvessel	microvessel	NOUN
dti-1294	184	2	density	density	NOUN
dti-1294	184	3	in	in	ADP
dti-1294	184	4	core	core	NOUN
dti-1294	184	5	biopsies	biopsy	NOUN
dti-1294	184	6	of	of	ADP
dti-1294	184	7	prostatic	prostatic	ADJ
dti-1294	184	8	adenocarcinoma	adenocarcinoma	NOUN
dti-1294	184	9	:	:	PUNCT
dti-1294	184	10	a	a	DET
dti-1294	184	11	stage	stage	NOUN
dti-1294	184	12	predictor	predictor	NOUN
dti-1294	184	13	.	.	PUNCT
dti-1294	185	1	j.	j.	PROPN
dti-1294	185	2	pathol	pathol	PROPN
dti-1294	185	3	.	.	PROPN
dti-1294	185	4	,	,	PUNCT
dti-1294	185	5	182:205–210	182:205–210	NUM
dti-1294	185	6	.	.	PUNCT
dti-1294	186	1	rubin	rubin	PROPN
dti-1294	186	2	,	,	PUNCT
dti-1294	186	3	m.a	m.a	PROPN
dti-1294	186	4	.	.	PROPN
dti-1294	186	5	buyyounouski	buyyounouski	PROPN
dti-1294	186	6	,	,	PUNCT
dti-1294	186	7	m.	m.	NOUN
dti-1294	186	8	and	and	CCONJ
dti-1294	186	9	bagilla	bagilla	NOUN
dti-1294	186	10	,	,	PUNCT
dti-1294	186	11	e.	e.	PROPN
dti-1294	186	12	et	et	PROPN
dti-1294	186	13	al	al	PROPN
dti-1294	186	14	.	.	PROPN
dti-1294	186	15	1999	1999	NUM
dti-1294	186	16	.	.	PUNCT
dti-1294	187	1	microvessel	microvessel	NOUN
dti-1294	187	2	density	density	NOUN
dti-1294	187	3	in	in	ADP
dti-1294	187	4	prostate	prostate	NOUN
dti-1294	187	5	cancer	cancer	NOUN
dti-1294	187	6	:	:	PUNCT
dti-1294	187	7	lack	lack	NOUN
dti-1294	187	8	of	of	ADP
dti-1294	187	9	correlation	correlation	NOUN
dti-1294	187	10	with	with	ADP
dti-1294	187	11	tumor	tumor	NOUN
dti-1294	187	12	grad	grad	NOUN
dti-1294	187	13	,	,	PUNCT
dti-1294	187	14	pathologic	pathologic	ADJ
dti-1294	187	15	stage	stage	NOUN
dti-1294	187	16	,	,	PUNCT
dti-1294	187	17	and	and	CCONJ
dti-1294	187	18	clinical	clinical	ADJ
dti-1294	187	19	outcome	outcome	NOUN
dti-1294	187	20	.	.	PUNCT
dti-1294	188	1	urology	urology	NOUN
dti-1294	188	2	,	,	PUNCT
dti-1294	188	3	53:542–547	53:542–547	PROPN
dti-1294	188	4	.	.	PUNCT
dti-1294	188	5	uster	uster	PROPN
dti-1294	188	6	,	,	PUNCT
dti-1294	188	7	p.s	p.s	PROPN
dti-1294	188	8	.	.	PROPN
dti-1294	188	9	,	,	PUNCT
dti-1294	188	10	working	working	NOUN
dti-1294	188	11	,	,	PUNCT
dti-1294	188	12	p.k	p.k	PROPN
dti-1294	188	13	.	.	PROPN
dti-1294	188	14	and	and	CCONJ
dti-1294	188	15	vaage	vaage	NOUN
dti-1294	188	16	,	,	PUNCT
dti-1294	188	17	j.	j.	PROPN
dti-1294	188	18	1998	1998	NUM
dti-1294	188	19	.	.	PUNCT
dti-1294	189	1	pegylated	pegylate	VERB
dti-1294	189	2	liposomal	liposomal	ADJ
dti-1294	189	3	doxorubicin	doxorubicin	PROPN
dti-1294	189	4	(	(	PUNCT
dti-1294	189	5	doxil	doxil	NOUN
dti-1294	189	6	,	,	PUNCT
dti-1294	189	7	caelyx	caelyx	NOUN
dti-1294	189	8	)	)	PUNCT
dti-1294	189	9	distribution	distribution	NOUN
dti-1294	189	10	in	in	ADP
dti-1294	189	11	tumour	tumour	NOUN
dti-1294	189	12	models	model	NOUN
dti-1294	189	13	observed	observe	VERB
dti-1294	189	14	with	with	ADP
dti-1294	189	15	confocal	confocal	ADJ
dti-1294	189	16	laser	laser	NOUN
dti-1294	189	17	scanning	scan	VERB
dti-1294	189	18	microscopy	microscopy	NOUN
dti-1294	189	19	.	.	PUNCT
dti-1294	190	1	international	international	ADJ
dti-1294	190	2	j.	j.	PROPN
dti-1294	190	3	pharmaceutics	pharmaceutics	PROPN
dti-1294	190	4	,	,	PUNCT
dti-1294	190	5	162:77–86	162:77–86	NUM
dti-1294	190	6	.	.	PUNCT
dti-1294	190	7	vaage	vaage	NOUN
dti-1294	190	8	,	,	PUNCT
dti-1294	190	9	j.	j.	PROPN
dti-1294	190	10	,	,	PUNCT
dti-1294	190	11	donovan	donovan	PROPN
dti-1294	190	12	,	,	PUNCT
dti-1294	190	13	d.	d.	PROPN
dti-1294	190	14	and	and	CCONJ
dti-1294	190	15	wipff	wipff	PROPN
dti-1294	190	16	,	,	PUNCT
dti-1294	190	17	e.	e.	PROPN
dti-1294	190	18	1999	1999	NUM
dti-1294	190	19	.	.	PUNCT
dti-1294	191	1	therapy	therapy	NOUN
dti-1294	191	2	of	of	ADP
dti-1294	191	3	a	a	DET
dti-1294	191	4	xenografted	xenografted	ADJ
dti-1294	191	5	human	human	ADJ
dti-1294	191	6	colonic	colonic	NOUN
dti-1294	191	7	carcinoma	carcinoma	NOUN
dti-1294	191	8	using	use	VERB
dti-1294	191	9	cisplatin	cisplatin	NOUN
dti-1294	191	10	or	or	CCONJ
dti-1294	191	11	doxorubicin	doxorubicin	PROPN
dti-1294	191	12	encapsulated	encapsulate	VERB
dti-1294	191	13	in	in	ADP
dti-1294	191	14	long	long	ADV
dti-1294	191	15	-	-	PUNCT
dti-1294	191	16	circulating	circulate	VERB
dti-1294	191	17	pegylated	pegylated	ADJ
dti-1294	191	18	stealth	stealth	ADJ
dti-1294	191	19	liposomes	liposome	NOUN
dti-1294	191	20	.	.	PUNCT
dti-1294	192	1	int	int	NOUN
dti-1294	192	2	.	.	PUNCT
dti-1294	193	1	j.	j.	PROPN
dti-1294	193	2	cancer	cancer	PROPN
dti-1294	193	3	,	,	PUNCT
dti-1294	193	4	80	80	NUM
dti-1294	193	5	:	:	PUNCT
dti-1294	193	6	134–137	134–137	NUM
dti-1294	193	7	.	.	PUNCT
dti-1294	194	1	vail	vail	PROPN
dti-1294	194	2	,	,	PUNCT
dti-1294	194	3	d.m	d.m	PROPN
dti-1294	194	4	.	.	PROPN
dti-1294	194	5	,	,	PUNCT
dti-1294	194	6	amantea	amantea	PROPN
dti-1294	194	7	,	,	PUNCT
dti-1294	194	8	m.a	m.a	PROPN
dti-1294	194	9	.	.	PROPN
dti-1294	194	10	and	and	CCONJ
dti-1294	194	11	colbern	colbern	PROPN
dti-1294	194	12	,	,	PUNCT
dti-1294	194	13	g.t	g.t	PROPN
dti-1294	194	14	.	.	PROPN
dti-1294	194	15	et	et	PROPN
dti-1294	194	16	al	al	PROPN
dti-1294	194	17	.	.	PROPN
dti-1294	194	18	2004	2004	NUM
dti-1294	194	19	.	.	PUNCT
dti-1294	195	1	pegylated	pegylate	VERB
dti-1294	195	2	liposomeal	liposomeal	NOUN
dti-1294	195	3	doxorybicin	doxorybicin	NOUN
dti-1294	195	4	:	:	PUNCT
dti-1294	195	5	proof	proof	NOUN
dti-1294	195	6	of	of	ADP
dti-1294	195	7	principle	principle	NOUN
dti-1294	195	8	using	use	VERB
dti-1294	195	9	preclinical	preclinical	ADJ
dti-1294	195	10	animal	animal	NOUN
dti-1294	195	11	models	model	NOUN
dti-1294	195	12	and	and	CCONJ
dti-1294	195	13	pharmacokinetic	pharmacokinetic	ADJ
dti-1294	195	14	studies	study	NOUN
dti-1294	195	15	.	.	PUNCT
dti-1294	196	1	semin	semin	PROPN
dti-1294	196	2	.	.	PUNCT
dti-1294	197	1	oncol	oncol	PROPN
dti-1294	197	2	.	.	PUNCT
dti-1294	198	1	,	,	PUNCT
dti-1294	198	2	31	31	NUM
dti-1294	198	3	(	(	PUNCT
dti-1294	198	4	6	6	NUM
dti-1294	198	5	suppl	suppl	ADJ
dti-1294	198	6	)	)	PUNCT
dti-1294	198	7	13:16–35	13:16–35	NUM
dti-1294	198	8	.	.	PUNCT