id	sid	tid	token	lemma	pos
dti-1295	1	1	stief	stief	PROPN
dti-1295	1	2	et	et	PROPN
dti-1295	1	3	al.indd	al.indd	NOUN
dti-1295	1	4	inhibition	inhibition	NOUN
dti-1295	1	5	of	of	ADP
dti-1295	1	6	intrinsic	intrinsic	ADJ
dti-1295	1	7	thrombin	thrombin	NOUN
dti-1295	1	8	generation	generation	NOUN
dti-1295	1	9	thomas	thomas	PROPN
dti-1295	1	10	w.	w.	PROPN
dti-1295	1	11	stief	stief	PROPN
dti-1295	1	12	department	department	PROPN
dti-1295	1	13	of	of	ADP
dti-1295	1	14	clinical	clinical	ADJ
dti-1295	1	15	chemistry	chemistry	NOUN
dti-1295	1	16	,	,	PUNCT
dti-1295	1	17	university	university	NOUN
dti-1295	1	18	hospital	hospital	NOUN
dti-1295	1	19	giessen	giessen	PROPN
dti-1295	1	20	&	&	CCONJ
dti-1295	1	21	marburg	marburg	PROPN
dti-1295	1	22	,	,	PUNCT
dti-1295	1	23	germany	germany	PROPN
dti-1295	1	24	.	.	PUNCT
dti-1295	2	1	abstract	abstract	ADJ
dti-1295	2	2	background	background	NOUN
dti-1295	2	3	:	:	PUNCT
dti-1295	2	4	the	the	DET
dti-1295	2	5	contact	contact	NOUN
dti-1295	2	6	phase	phase	NOUN
dti-1295	2	7	of	of	ADP
dti-1295	2	8	coagulation	coagulation	NOUN
dti-1295	2	9	is	be	AUX
dti-1295	2	10	of	of	ADP
dti-1295	2	11	physiologic	physiologic	ADJ
dti-1295	2	12	/	/	SYM
dti-1295	2	13	pathophysiologic	pathophysiologic	ADJ
dti-1295	2	14	importance	importance	NOUN
dti-1295	2	15	,	,	PUNCT
dti-1295	2	16	whenever	whenever	SCONJ
dti-1295	2	17	unphysiologic	unphysiologic	ADJ
dti-1295	2	18	polynegative	polynegative	ADJ
dti-1295	2	19	substances	substance	NOUN
dti-1295	2	20	such	such	ADJ
dti-1295	2	21	as	as	ADP
dti-1295	2	22	cell	cell	NOUN
dti-1295	2	23	fragments	fragment	NOUN
dti-1295	2	24	(	(	PUNCT
dti-1295	2	25	microparticles	microparticle	NOUN
dti-1295	2	26	)	)	PUNCT
dti-1295	2	27	get	get	VERB
dti-1295	2	28	in	in	ADP
dti-1295	2	29	contact	contact	NOUN
dti-1295	2	30	with	with	ADP
dti-1295	2	31	blood	blood	NOUN
dti-1295	2	32	.	.	PUNCT
dti-1295	3	1	there	there	PRON
dti-1295	3	2	are	be	VERB
dti-1295	3	3	several	several	ADJ
dti-1295	3	4	clinically	clinically	ADV
dti-1295	3	5	used	use	VERB
dti-1295	3	6	inhibitors	inhibitor	NOUN
dti-1295	3	7	of	of	ADP
dti-1295	3	8	intrinsic	intrinsic	ADJ
dti-1295	3	9	thrombin	thrombin	NOUN
dti-1295	3	10	generation	generation	NOUN
dti-1295	3	11	.	.	PUNCT
dti-1295	4	1	here	here	ADV
dti-1295	4	2	the	the	DET
dti-1295	4	3	inhibitory	inhibitory	ADJ
dti-1295	4	4	concentrations	concentration	NOUN
dti-1295	4	5	50	50	NUM
dti-1295	4	6	%	%	NOUN
dti-1295	4	7	(	(	PUNCT
dti-1295	4	8	ic50	ic50	PROPN
dti-1295	4	9	)	)	PUNCT
dti-1295	4	10	of	of	ADP
dti-1295	4	11	these	these	DET
dti-1295	4	12	anticoagulants	anticoagulant	NOUN
dti-1295	4	13	are	be	AUX
dti-1295	4	14	measured	measure	VERB
dti-1295	4	15	by	by	ADP
dti-1295	4	16	the	the	DET
dti-1295	4	17	highly	highly	ADV
dti-1295	4	18	specifi	specifi	PROPN
dti-1295	4	19	c	c	NOUN
dti-1295	4	20	thrombin	thrombin	NOUN
dti-1295	4	21	generation	generation	NOUN
dti-1295	4	22	assay	assay	PROPN
dti-1295	4	23	inca	inca	PROPN
dti-1295	4	24	.	.	PUNCT
dti-1295	5	1	methods	method	NOUN
dti-1295	5	2	:	:	PUNCT
dti-1295	5	3	unfrozen	unfrozen	PROPN
dti-1295	5	4	pooled	pool	VERB
dti-1295	5	5	normal	normal	ADJ
dti-1295	5	6	citrated	citrate	VERB
dti-1295	5	7	plasma	plasma	NOUN
dti-1295	5	8	in	in	ADP
dti-1295	5	9	polystyrole	polystyrole	PROPN
dti-1295	5	10	tubes	tube	NOUN
dti-1295	5	11	was	be	AUX
dti-1295	5	12	supplemented	supplement	VERB
dti-1295	5	13	at	at	ADP
dti-1295	5	14	23	23	NUM
dti-1295	5	15	°	°	ADP
dti-1295	5	16	c	c	NOUN
dti-1295	5	17	in	in	ADP
dti-1295	5	18	duplicate	duplicate	NOUN
dti-1295	5	19	with	with	ADP
dti-1295	5	20	0–2	0–2	NOUN
dti-1295	5	21	iu	iu	NOUN
dti-1295	5	22	/	/	SYM
dti-1295	5	23	ml	ml	ADV
dti-1295	5	24	low	low	ADJ
dti-1295	5	25	molecular	molecular	ADJ
dti-1295	5	26	weight	weight	NOUN
dti-1295	5	27	heparin	heparin	NOUN
dti-1295	5	28	(	(	PUNCT
dti-1295	5	29	dalteparin	dalteparin	NOUN
dti-1295	5	30	)	)	PUNCT
dti-1295	5	31	,	,	PUNCT
dti-1295	6	1	0–2	0–2	PUNCT
dti-1295	6	2	iu	iu	ADP
dti-1295	6	3	/	/	SYM
dti-1295	6	4	ml	ml	VERB
dti-1295	6	5	unfractionated	unfractionate	VERB
dti-1295	6	6	heparin	heparin	NOUN
dti-1295	6	7	,	,	PUNCT
dti-1295	6	8	0–500	0–500	NUM
dti-1295	6	9	kiu	kiu	PROPN
dti-1295	6	10	/	/	SYM
dti-1295	6	11	ml	ml	NOUN
dti-1295	6	12	aprotinin	aprotinin	NOUN
dti-1295	6	13	,	,	PUNCT
dti-1295	6	14	or	or	CCONJ
dti-1295	6	15	0–40	0–40	VERB
dti-1295	6	16	mm	mm	NUM
dti-1295	6	17	arginine	arginine	NOUN
dti-1295	6	18	.	.	PUNCT
dti-1295	7	1	50	50	NUM
dti-1295	7	2	µl	µl	ADP
dti-1295	7	3	plasma	plasma	NOUN
dti-1295	7	4	or	or	CCONJ
dti-1295	7	5	1	1	NUM
dti-1295	7	6	iu	iu	ADV
dti-1295	7	7	/	/	SYM
dti-1295	7	8	ml	ml	NOUN
dti-1295	7	9	thrombin	thrombin	NOUN
dti-1295	7	10	standard	standard	NOUN
dti-1295	7	11	were	be	AUX
dti-1295	7	12	pipetted	pipette	VERB
dti-1295	7	13	into	into	ADP
dti-1295	7	14	a	a	DET
dti-1295	7	15	polystyrole	polystyrole	ADJ
dti-1295	7	16	microtiter	microtiter	NOUN
dti-1295	7	17	plate	plate	NOUN
dti-1295	7	18	with	with	ADP
dti-1295	7	19	fl	fl	PROPN
dti-1295	7	20	at	at	ADP
dti-1295	7	21	bottom	bottom	NOUN
dti-1295	7	22	.	.	PUNCT
dti-1295	8	1	5	5	NUM
dti-1295	8	2	µl	µl	NOUN
dti-1295	8	3	sio2/	sio2/	PROPN
dti-1295	8	4	cacl2	cacl2	NOUN
dti-1295	8	5	reagent	reagent	NOUN
dti-1295	8	6	(	(	PUNCT
dti-1295	8	7	inca	inca	NOUN
dti-1295	8	8	activator	activator	NOUN
dti-1295	8	9	)	)	PUNCT
dti-1295	8	10	were	be	AUX
dti-1295	8	11	added	add	VERB
dti-1295	8	12	and	and	CCONJ
dti-1295	8	13	after	after	ADP
dti-1295	8	14	0–30	0–30	PROPN
dti-1295	8	15	min	min	PROPN
dti-1295	8	16	incubation	incubation	PROPN
dti-1295	8	17	at	at	ADP
dti-1295	8	18	37	37	NUM
dti-1295	8	19	°	°	NOUN
dti-1295	8	20	c	c	NOUN
dti-1295	8	21	100	100	NUM
dti-1295	8	22	µl	µl	ADP
dti-1295	8	23	2.5	2.5	NUM
dti-1295	8	24	m	m	NOUN
dti-1295	8	25	arginine	arginine	NOUN
dti-1295	8	26	,	,	PUNCT
dti-1295	8	27	ph	ph	NOUN
dti-1295	8	28	8.6	8.6	NUM
dti-1295	8	29	,	,	PUNCT
dti-1295	8	30	were	be	AUX
dti-1295	8	31	added	add	VERB
dti-1295	8	32	;	;	PUNCT
dti-1295	8	33	arginine	arginine	NOUN
dti-1295	8	34	inhibits	inhibit	VERB
dti-1295	8	35	hemostasis	hemostasis	NOUN
dti-1295	8	36	activation	activation	NOUN
dti-1295	8	37	and	and	CCONJ
dti-1295	8	38	depolymerizes	depolymerize	NOUN
dti-1295	8	39	generated	generate	VERB
dti-1295	8	40	fi	fi	NOUN
dti-1295	8	41	brin	brin	NOUN
dti-1295	8	42	within	within	ADP
dti-1295	8	43	20	20	NUM
dti-1295	8	44	min	min	NOUN
dti-1295	8	45	at	at	ADP
dti-1295	8	46	23	23	NUM
dti-1295	8	47	°	°	NOUN
dti-1295	8	48	c	c	NOUN
dti-1295	8	49	.	.	PUNCT
dti-1295	9	1	the	the	PRON
dti-1295	9	2	in	in	ADP
dti-1295	9	3	the	the	DET
dti-1295	9	4	physiologic	physiologic	ADJ
dti-1295	9	5	37	37	NUM
dti-1295	9	6	°	°	NOUN
dti-1295	9	7	c	c	NOUN
dti-1295	9	8	incubation	incubation	NOUN
dti-1295	9	9	phase	phase	NOUN
dti-1295	9	10	generated	generate	VERB
dti-1295	9	11	thrombin	thrombin	NOUN
dti-1295	9	12	was	be	AUX
dti-1295	9	13	then	then	ADV
dti-1295	9	14	chromogenically	chromogenically	ADV
dti-1295	9	15	detected	detect	VERB
dti-1295	9	16	.	.	PUNCT
dti-1295	10	1	the	the	DET
dti-1295	10	2	intra	intra	ADJ
dti-1295	10	3	-	-	ADJ
dti-1295	10	4	assay	assay	ADJ
dti-1295	10	5	cv	cv	PROPN
dti-1295	10	6	values	value	NOUN
dti-1295	10	7	were	be	AUX
dti-1295	10	8	<	<	X
dti-1295	10	9	5	5	NUM
dti-1295	10	10	%	%	NOUN
dti-1295	10	11	.	.	PUNCT
dti-1295	11	1	results	result	NOUN
dti-1295	11	2	and	and	CCONJ
dti-1295	11	3	discussion	discussion	NOUN
dti-1295	11	4	:	:	PUNCT
dti-1295	11	5	the	the	DET
dti-1295	11	6	approximate	approximate	ADJ
dti-1295	11	7	ic50	ic50	PROPN
dti-1295	11	8	were	be	AUX
dti-1295	11	9	0.01	0.01	NUM
dti-1295	11	10	iu	iu	NOUN
dti-1295	11	11	/	/	SYM
dti-1295	11	12	ml	ml	NOUN
dti-1295	11	13	dalteparin	dalteparin	NOUN
dti-1295	11	14	,	,	PUNCT
dti-1295	11	15	0.02	0.02	NUM
dti-1295	11	16	iu	iu	NOUN
dti-1295	11	17	/	/	SYM
dti-1295	11	18	ml	ml	NOUN
dti-1295	11	19	heparin	heparin	NOUN
dti-1295	11	20	,	,	PUNCT
dti-1295	11	21	25	25	NUM
dti-1295	11	22	kiu	kiu	NOUN
dti-1295	11	23	/	/	SYM
dti-1295	11	24	ml	ml	NOUN
dti-1295	11	25	aprotinin	aprotinin	NOUN
dti-1295	11	26	,	,	PUNCT
dti-1295	11	27	and	and	CCONJ
dti-1295	11	28	12	12	NUM
dti-1295	11	29	mm	mm	NOUN
dti-1295	11	30	arginine	arginine	NOUN
dti-1295	11	31	.	.	PUNCT
dti-1295	12	1	the	the	DET
dti-1295	12	2	effi	effi	PROPN
dti-1295	12	3	ciency	ciency	NOUN
dti-1295	12	4	of	of	ADP
dti-1295	12	5	any	any	DET
dti-1295	12	6	anticoagulant	anticoagulant	NOUN
dti-1295	12	7	on	on	ADP
dti-1295	12	8	intrinsic	intrinsic	ADJ
dti-1295	12	9	thrombin	thrombin	NOUN
dti-1295	12	10	generation	generation	NOUN
dti-1295	12	11	should	should	AUX
dti-1295	12	12	be	be	AUX
dti-1295	12	13	measured	measure	VERB
dti-1295	12	14	for	for	ADP
dti-1295	12	15	each	each	DET
dti-1295	12	16	individual	individual	ADJ
dti-1295	12	17	patient	patient	NOUN
dti-1295	12	18	.	.	PUNCT
dti-1295	13	1	abbreviations	abbreviation	NOUN
dti-1295	13	2	:	:	PUNCT
dti-1295	13	3	iia	iia	NOUN
dti-1295	13	4	,	,	PUNCT
dti-1295	13	5	thrombin	thrombin	NOUN
dti-1295	13	6	;	;	PUNCT
dti-1295	13	7	∆a	∆a	NOUN
dti-1295	13	8	,	,	PUNCT
dti-1295	13	9	increase	increase	VERB
dti-1295	13	10	in	in	ADP
dti-1295	13	11	absorbance	absorbance	NOUN
dti-1295	13	12	;	;	PUNCT
dti-1295	13	13	aptt	aptt	ADJ
dti-1295	13	14	,	,	PUNCT
dti-1295	13	15	activated	activate	VERB
dti-1295	13	16	partial	partial	ADJ
dti-1295	13	17	thromboplastin	thromboplastin	NOUN
dti-1295	13	18	time	time	NOUN
dti-1295	13	19	;	;	PUNCT
dti-1295	13	20	crt	crt	ADJ
dti-1295	13	21	,	,	PUNCT
dti-1295	13	22	coagulation	coagulation	NOUN
dti-1295	13	23	reaction	reaction	NOUN
dti-1295	13	24	time	time	NOUN
dti-1295	13	25	(	(	PUNCT
dti-1295	13	26	at	at	ADP
dti-1295	13	27	37	37	NUM
dti-1295	13	28	°	°	NOUN
dti-1295	13	29	c	c	NOUN
dti-1295	13	30	in	in	ADP
dti-1295	13	31	water	water	NOUN
dti-1295	13	32	-	-	PUNCT
dti-1295	13	33	bath	bath	NOUN
dti-1295	13	34	)	)	PUNCT
dti-1295	13	35	;	;	PUNCT
dti-1295	14	1	f	f	X
dti-1295	14	2	-	-	PUNCT
dti-1295	14	3	wells	wells	PROPN
dti-1295	14	4	,	,	PUNCT
dti-1295	14	5	polystyrole	polystyrole	ADJ
dti-1295	14	6	microtiter	microtiter	NOUN
dti-1295	14	7	plates	plate	NOUN
dti-1295	14	8	with	with	ADP
dti-1295	14	9	fl	fl	PROPN
dti-1295	14	10	at	at	ADP
dti-1295	14	11	bottom	bottom	NOUN
dti-1295	14	12	;	;	PUNCT
dti-1295	14	13	ic50	ic50	PROPN
dti-1295	14	14	,	,	PUNCT
dti-1295	14	15	inhibitory	inhibitory	ADJ
dti-1295	14	16	concentration	concentration	NOUN
dti-1295	14	17	50	50	NUM
dti-1295	14	18	%	%	NOUN
dti-1295	14	19	;	;	PUNCT
dti-1295	14	20	inca	inca	PROPN
dti-1295	14	21	,	,	PUNCT
dti-1295	14	22	intrinsic	intrinsic	ADJ
dti-1295	14	23	coagulation	coagulation	NOUN
dti-1295	14	24	activity	activity	NOUN
dti-1295	14	25	assay	assay	VERB
dti-1295	14	26	;	;	PUNCT
dti-1295	14	27	iu	iu	ADP
dti-1295	14	28	,	,	PUNCT
dti-1295	14	29	international	international	ADJ
dti-1295	14	30	units	unit	NOUN
dti-1295	14	31	;	;	PUNCT
dti-1295	14	32	kiu	kiu	PROPN
dti-1295	14	33	,	,	PUNCT
dti-1295	14	34	kallikrein	kallikrein	VERB
dti-1295	14	35	inhibiting	inhibit	VERB
dti-1295	14	36	unis	uni	NOUN
dti-1295	14	37	;	;	PUNCT
dti-1295	14	38	lmwh	lmwh	ADJ
dti-1295	14	39	,	,	PUNCT
dti-1295	14	40	low	low	ADJ
dti-1295	14	41	molecular	molecular	ADJ
dti-1295	14	42	weight	weight	NOUN
dti-1295	14	43	heparin	heparin	NOUN
dti-1295	14	44	;	;	PUNCT
dti-1295	14	45	ma	ma	PROPN
dti-1295	14	46	,	,	PUNCT
dti-1295	14	47	milli	milli	ADJ
dti-1295	14	48	-	-	PUNCT
dti-1295	14	49	absorbance	absorbance	NOUN
dti-1295	14	50	units	unit	NOUN
dti-1295	14	51	;	;	PUNCT
dti-1295	14	52	psl	psl	PROPN
dti-1295	14	53	,	,	PUNCT
dti-1295	14	54	pathromtin	pathromtin	PROPN
dti-1295	14	55	sl	sl	PROPN
dti-1295	14	56	®	®	PROPN
dti-1295	14	57	;	;	PUNCT
dti-1295	14	58	rt	rt	NOUN
dti-1295	14	59	,	,	PUNCT
dti-1295	14	60	room	room	NOUN
dti-1295	14	61	temperature	temperature	NOUN
dti-1295	14	62	(	(	PUNCT
dti-1295	14	63	23	23	NUM
dti-1295	14	64	°	°	ADP
dti-1295	14	65	c	c	NOUN
dti-1295	14	66	)	)	PUNCT
dti-1295	14	67	;	;	PUNCT
dti-1295	14	68	u	u	NOUN
dti-1295	14	69	-	-	NOUN
dti-1295	14	70	wells	wells	PROPN
dti-1295	14	71	,	,	PUNCT
dti-1295	14	72	polystyrole	polystyrole	ADJ
dti-1295	14	73	microtiter	microtiter	NOUN
dti-1295	14	74	plates	plate	NOUN
dti-1295	14	75	with	with	ADP
dti-1295	14	76	round	round	ADJ
dti-1295	14	77	bottom	bottom	NOUN
dti-1295	14	78	.	.	PUNCT
dti-1295	15	1	keywords	keyword	NOUN
dti-1295	15	2	:	:	PUNCT
dti-1295	15	3	inca	inca	PROPN
dti-1295	15	4	,	,	PUNCT
dti-1295	15	5	thrombin	thrombin	NOUN
dti-1295	15	6	,	,	PUNCT
dti-1295	15	7	lmw	lmw	ADJ
dti-1295	15	8	-	-	PUNCT
dti-1295	15	9	heparin	heparin	NOUN
dti-1295	15	10	,	,	PUNCT
dti-1295	15	11	dalteparin	dalteparin	NOUN
dti-1295	15	12	,	,	PUNCT
dti-1295	15	13	heparin	heparin	NOUN
dti-1295	15	14	,	,	PUNCT
dti-1295	15	15	aprotinin	aprotinin	NOUN
dti-1295	15	16	,	,	PUNCT
dti-1295	15	17	arginine	arginine	NOUN
dti-1295	15	18	introduction	introduction	NOUN
dti-1295	15	19	low	low	ADJ
dti-1295	15	20	molecular	molecular	ADJ
dti-1295	15	21	weight	weight	NOUN
dti-1295	15	22	heparins	heparin	NOUN
dti-1295	15	23	(	(	PUNCT
dti-1295	15	24	lmwh	lmwh	PROPN
dti-1295	15	25	)	)	PUNCT
dti-1295	15	26	are	be	AUX
dti-1295	15	27	essential	essential	ADJ
dti-1295	15	28	drugs	drug	NOUN
dti-1295	15	29	for	for	ADP
dti-1295	15	30	patients	patient	NOUN
dti-1295	15	31	inside	inside	ADP
dti-1295	15	32	and	and	CCONJ
dti-1295	15	33	outside	outside	ADP
dti-1295	15	34	the	the	DET
dti-1295	15	35	hospital	hospital	NOUN
dti-1295	15	36	;	;	PUNCT
dti-1295	15	37	unfortunately	unfortunately	ADV
dti-1295	15	38	,	,	PUNCT
dti-1295	15	39	the	the	DET
dti-1295	15	40	global	global	ADJ
dti-1295	15	41	hemostasis	hemostasis	NOUN
dti-1295	15	42	assay	assay	PROPN
dti-1295	15	43	aptt	aptt	PROPN
dti-1295	15	44	is	be	AUX
dti-1295	15	45	not	not	PART
dti-1295	15	46	sensitive	sensitive	ADJ
dti-1295	15	47	to	to	ADP
dti-1295	15	48	lmwh	lmwh	NOUN
dti-1295	16	1	[	[	X
dti-1295	16	2	fareed	fareed	PROPN
dti-1295	16	3	et	et	PROPN
dti-1295	16	4	al	al	PROPN
dti-1295	16	5	.	.	PROPN
dti-1295	16	6	2004	2004	NUM
dti-1295	16	7	]	]	PUNCT
dti-1295	16	8	.	.	PUNCT
dti-1295	17	1	there	there	PRON
dti-1295	17	2	is	be	VERB
dti-1295	17	3	clinical	clinical	ADJ
dti-1295	17	4	need	need	NOUN
dti-1295	17	5	for	for	ADP
dti-1295	17	6	a	a	DET
dti-1295	17	7	simple	simple	ADJ
dti-1295	17	8	physiologic	physiologic	ADJ
dti-1295	17	9	global	global	ADJ
dti-1295	17	10	hemostasis	hemostasis	NOUN
dti-1295	17	11	test	test	NOUN
dti-1295	17	12	that	that	PRON
dti-1295	17	13	monitors	monitor	VERB
dti-1295	17	14	the	the	DET
dti-1295	17	15	anticoagulant	anticoagulant	ADJ
dti-1295	17	16	power	power	NOUN
dti-1295	17	17	of	of	ADP
dti-1295	17	18	lmwh	lmwh	NOUN
dti-1295	17	19	.	.	PUNCT
dti-1295	18	1	the	the	DET
dti-1295	18	2	only	only	ADJ
dti-1295	18	3	lmwh	lmwh	ADJ
dti-1295	18	4	routine	routine	NOUN
dti-1295	18	5	assay	assay	PROPN
dti-1295	18	6	currently	currently	ADV
dti-1295	18	7	available	available	ADJ
dti-1295	18	8	is	be	AUX
dti-1295	18	9	the	the	DET
dti-1295	18	10	anti	anti	ADJ
dti-1295	18	11	-	-	ADJ
dti-1295	18	12	xa	xa	ADJ
dti-1295	18	13	assay	assay	PROPN
dti-1295	18	14	,	,	PUNCT
dti-1295	18	15	that	that	PRON
dti-1295	18	16	is	be	AUX
dti-1295	18	17	available	available	ADJ
dti-1295	18	18	in	in	ADP
dti-1295	18	19	a	a	DET
dti-1295	18	20	clotting	clotting	NOUN
dti-1295	18	21	[	[	X
dti-1295	18	22	denson	denson	PROPN
dti-1295	18	23	and	and	CCONJ
dti-1295	18	24	bonnar	bonnar	PROPN
dti-1295	18	25	,	,	PUNCT
dti-1295	18	26	1973	1973	NUM
dti-1295	18	27	]	]	PUNCT
dti-1295	18	28	and	and	CCONJ
dti-1295	18	29	in	in	ADP
dti-1295	18	30	a	a	DET
dti-1295	18	31	chromogenic	chromogenic	ADJ
dti-1295	18	32	version	version	NOUN
dti-1295	18	33	[	[	X
dti-1295	18	34	teien	teien	X
dti-1295	18	35	et	et	PROPN
dti-1295	18	36	al	al	PROPN
dti-1295	18	37	.	.	PROPN
dti-1295	18	38	1976	1976	NUM
dti-1295	18	39	]	]	PUNCT
dti-1295	18	40	.	.	PUNCT
dti-1295	19	1	however	however	ADV
dti-1295	19	2	,	,	PUNCT
dti-1295	19	3	the	the	DET
dti-1295	19	4	target	target	NOUN
dti-1295	19	5	therapeutic	therapeutic	ADJ
dti-1295	19	6	dose	dose	NOUN
dti-1295	19	7	range	range	NOUN
dti-1295	19	8	in	in	ADP
dti-1295	19	9	the	the	DET
dti-1295	19	10	anti	anti	NOUN
dti-1295	19	11	-	-	PROPN
dti-1295	19	12	xa	xa	PROPN
dti-1295	19	13	assay	assay	PROPN
dti-1295	19	14	is	be	AUX
dti-1295	19	15	0.4–0.7	0.4–0.7	ADJ
dti-1295	19	16	iu	iu	ADP
dti-1295	19	17	/	/	SYM
dti-1295	19	18	ml	ml	NOUN
dti-1295	19	19	heparin	heparin	NOUN
dti-1295	19	20	in	in	ADP
dti-1295	19	21	the	the	DET
dti-1295	19	22	anti	anti	PROPN
dti-1295	19	23	-	-	PROPN
dti-1295	19	24	xa	xa	ADJ
dti-1295	19	25	assay	assay	NOUN
dti-1295	19	26	but	but	CCONJ
dti-1295	19	27	only	only	ADV
dti-1295	19	28	0.2–0.4	0.2–0.4	X
dti-1295	20	1	iu	iu	X
dti-1295	20	2	/	/	SYM
dti-1295	20	3	ml	ml	NOUN
dti-1295	20	4	heparin	heparin	NOUN
dti-1295	20	5	in	in	ADP
dti-1295	20	6	the	the	DET
dti-1295	20	7	aptt	aptt	NOUN
dti-1295	21	1	[	[	X
dti-1295	21	2	kitchen	kitchen	NOUN
dti-1295	21	3	,	,	PUNCT
dti-1295	21	4	2000	2000	NUM
dti-1295	21	5	]	]	PUNCT
dti-1295	21	6	.	.	PUNCT
dti-1295	22	1	this	this	DET
dti-1295	22	2	discrepancy	discrepancy	NOUN
dti-1295	22	3	indicates	indicate	VERB
dti-1295	22	4	that	that	SCONJ
dti-1295	22	5	the	the	DET
dti-1295	22	6	xa	xa	PROPN
dti-1295	22	7	activity	activity	NOUN
dti-1295	22	8	added	add	VERB
dti-1295	22	9	in	in	ADP
dti-1295	22	10	the	the	DET
dti-1295	22	11	anti	anti	NOUN
dti-1295	22	12	-	-	ADJ
dti-1295	22	13	xa	xa	ADJ
dti-1295	22	14	assays	assay	NOUN
dti-1295	22	15	might	might	AUX
dti-1295	22	16	be	be	AUX
dti-1295	22	17	supra	supra	ADJ
dti-1295	22	18	-	-	PUNCT
dti-1295	22	19	physiological	physiological	NOUN
dti-1295	22	20	and	and	CCONJ
dti-1295	22	21	that	that	SCONJ
dti-1295	22	22	the	the	DET
dti-1295	22	23	other	other	ADJ
dti-1295	22	24	pharmacologic	pharmacologic	ADJ
dti-1295	22	25	actions	action	NOUN
dti-1295	22	26	of	of	ADP
dti-1295	22	27	the	the	DET
dti-1295	22	28	heparins	heparin	NOUN
dti-1295	22	29	than	than	ADP
dti-1295	22	30	just	just	ADV
dti-1295	22	31	the	the	DET
dti-1295	22	32	inhibition	inhibition	NOUN
dti-1295	22	33	of	of	ADP
dti-1295	22	34	activated	activate	VERB
dti-1295	22	35	factor	factor	NOUN
dti-1295	22	36	x	x	PRON
dti-1295	22	37	are	be	AUX
dti-1295	22	38	not	not	PART
dti-1295	22	39	refl	refl	NOUN
dti-1295	22	40	ected	ecte	VERB
dti-1295	22	41	by	by	ADP
dti-1295	22	42	the	the	DET
dti-1295	22	43	anti	anti	PROPN
dti-1295	22	44	-	-	PROPN
dti-1295	22	45	xa	xa	ADJ
dti-1295	22	46	assay	assay	NOUN
dti-1295	22	47	.	.	PUNCT
dti-1295	23	1	recently	recently	ADV
dti-1295	23	2	,	,	PUNCT
dti-1295	23	3	a	a	DET
dti-1295	23	4	new	new	ADJ
dti-1295	23	5	test	test	NOUN
dti-1295	23	6	for	for	ADP
dti-1295	23	7	thrombin	thrombin	NOUN
dti-1295	23	8	activity	activity	NOUN
dti-1295	23	9	in	in	ADP
dti-1295	23	10	plasma	plasma	NOUN
dti-1295	23	11	was	be	AUX
dti-1295	23	12	developed	develop	VERB
dti-1295	23	13	[	[	X
dti-1295	23	14	stief	stief	NOUN
dti-1295	23	15	,	,	PUNCT
dti-1295	23	16	2006	2006	NUM
dti-1295	23	17	;	;	PUNCT
dti-1295	23	18	stief	stief	PROPN
dti-1295	23	19	et	et	PROPN
dti-1295	23	20	al	al	PROPN
dti-1295	23	21	.	.	PROPN
dti-1295	23	22	2006	2006	NUM
dti-1295	23	23	]	]	PUNCT
dti-1295	23	24	.	.	PUNCT
dti-1295	24	1	this	this	DET
dti-1295	24	2	assay	assay	PROPN
dti-1295	24	3	uses	use	VERB
dti-1295	24	4	(	(	PUNCT
dti-1295	24	5	i	i	NOUN
dti-1295	24	6	)	)	PUNCT
dti-1295	24	7	a	a	DET
dti-1295	24	8	chromogenic	chromogenic	ADJ
dti-1295	24	9	thrombin	thrombin	NOUN
dti-1295	24	10	substrate	substrate	NOUN
dti-1295	24	11	at	at	ADP
dti-1295	24	12	fi	fi	NOUN
dti-1295	24	13	nal	nal	ADJ
dti-1295	24	14	concentrations	concentration	NOUN
dti-1295	24	15	<	<	X
dti-1295	24	16	0.6	0.6	NUM
dti-1295	24	17	mm	mm	INTJ
dti-1295	24	18	and	and	CCONJ
dti-1295	24	19	(	(	PUNCT
dti-1295	24	20	ii	ii	NOUN
dti-1295	24	21	)	)	PUNCT
dti-1295	24	22	arginine	arginine	NOUN
dti-1295	24	23	at	at	ADP
dti-1295	24	24	fi	fi	NOUN
dti-1295	24	25	nal	nal	ADJ
dti-1295	24	26	concentrations	concentration	NOUN
dti-1295	24	27	>	>	X
dti-1295	24	28	1	1	NUM
dti-1295	24	29	m	m	NOUN
dti-1295	24	30	,	,	PUNCT
dti-1295	24	31	resulting	result	VERB
dti-1295	24	32	in	in	ADP
dti-1295	24	33	highly	highly	ADV
dti-1295	24	34	specifi	specifi	PROPN
dti-1295	24	35	c	c	PROPN
dti-1295	24	36	thrombin	thrombin	NOUN
dti-1295	24	37	determination	determination	NOUN
dti-1295	24	38	.	.	PUNCT
dti-1295	25	1	of	of	ADP
dti-1295	25	2	diagnostic	diagnostic	ADJ
dti-1295	25	3	importance	importance	NOUN
dti-1295	25	4	are	be	AUX
dti-1295	25	5	the	the	DET
dti-1295	25	6	following	follow	VERB
dti-1295	25	7	chromogenic	chromogenic	ADJ
dti-1295	25	8	thrombin	thrombin	NOUN
dti-1295	25	9	tests	test	VERB
dti-1295	25	10	that	that	SCONJ
dti-1295	25	11	all	all	DET
dti-1295	25	12	base	base	NOUN
dti-1295	25	13	on	on	ADP
dti-1295	25	14	this	this	DET
dti-1295	25	15	new	new	ADJ
dti-1295	25	16	technique	technique	NOUN
dti-1295	25	17	:	:	PUNCT
dti-1295	26	1	1	1	NUM
dti-1295	26	2	.	.	X
dti-1295	26	3	basal	basal	ADJ
dti-1295	26	4	thrombin	thrombin	NOUN
dti-1295	26	5	activity	activity	NOUN
dti-1295	26	6	(	(	PUNCT
dti-1295	26	7	iia	iia	NOUN
dti-1295	26	8	)	)	PUNCT
dti-1295	26	9	2	2	NUM
dti-1295	26	10	.	.	X
dti-1295	27	1	recalcifi	recalcifi	VERB
dti-1295	27	2	ed	ed	NOUN
dti-1295	27	3	coagulation	coagulation	NOUN
dti-1295	27	4	activity	activity	NOUN
dti-1295	27	5	assay	assay	NOUN
dti-1295	27	6	(	(	PUNCT
dti-1295	27	7	reca	reca	NOUN
dti-1295	27	8	)	)	PUNCT
dti-1295	27	9	3	3	NUM
dti-1295	27	10	.	.	PUNCT
dti-1295	27	11	intrinsic	intrinsic	ADJ
dti-1295	27	12	coagulation	coagulation	NOUN
dti-1295	27	13	activity	activity	NOUN
dti-1295	27	14	assay	assay	NOUN
dti-1295	27	15	(	(	PUNCT
dti-1295	27	16	inca	inca	PROPN
dti-1295	27	17	)	)	PUNCT
dti-1295	27	18	4	4	NUM
dti-1295	27	19	.	.	NOUN
dti-1295	27	20	extrinsic	extrinsic	ADJ
dti-1295	27	21	coagulation	coagulation	NOUN
dti-1295	27	22	activity	activity	NOUN
dti-1295	27	23	assay	assay	NOUN
dti-1295	27	24	(	(	PUNCT
dti-1295	27	25	exca	exca	PROPN
dti-1295	27	26	)	)	PUNCT
dti-1295	27	27	.	.	PUNCT
dti-1295	28	1	as	as	SCONJ
dti-1295	28	2	equipment	equipment	NOUN
dti-1295	28	3	only	only	ADV
dti-1295	28	4	a	a	DET
dti-1295	28	5	normal	normal	ADJ
dti-1295	28	6	microtiterplate	microtiterplate	NOUN
dti-1295	28	7	reader	reader	NOUN
dti-1295	28	8	is	be	AUX
dti-1295	28	9	required	require	VERB
dti-1295	28	10	;	;	PUNCT
dti-1295	28	11	these	these	DET
dti-1295	28	12	only	only	ADV
dti-1295	28	13	1	1	NUM
dti-1295	28	14	or	or	CCONJ
dti-1295	28	15	2	2	NUM
dti-1295	28	16	measuring	measuring	NOUN
dti-1295	28	17	point	point	NOUN
dti-1295	28	18	based	base	VERB
dti-1295	28	19	tests	test	NOUN
dti-1295	28	20	are	be	AUX
dti-1295	28	21	easy	easy	ADJ
dti-1295	28	22	to	to	PART
dti-1295	28	23	handle	handle	VERB
dti-1295	28	24	with	with	ADP
dti-1295	28	25	high	high	ADJ
dti-1295	28	26	reproducibility	reproducibility	NOUN
dti-1295	28	27	(	(	PUNCT
dti-1295	28	28	all	all	PRON
dti-1295	28	29	have	have	VERB
dti-1295	28	30	intra	intra	ADJ
dti-1295	28	31	-	-	ADJ
dti-1295	28	32	assay	assay	ADJ
dti-1295	28	33	cv	cv	PROPN
dti-1295	28	34	values	value	NOUN
dti-1295	28	35	less	less	ADJ
dti-1295	28	36	than	than	ADP
dti-1295	28	37	5	5	NUM
dti-1295	28	38	%	%	NOUN
dti-1295	28	39	)	)	PUNCT
dti-1295	28	40	,	,	PUNCT
dti-1295	28	41	correspondence	correspondence	NOUN
dti-1295	28	42	:	:	PUNCT
dti-1295	29	1	t.w	t.w	PROPN
dti-1295	29	2	.	.	PROPN
dti-1295	29	3	stief	stief	PROPN
dti-1295	29	4	,	,	PUNCT
dti-1295	29	5	md	md	PROPN
dti-1295	29	6	,	,	PUNCT
dti-1295	29	7	priv.-doz	priv.-doz	X
dti-1295	29	8	.	.	PUNCT
dti-1295	29	9	department	department	NOUN
dti-1295	29	10	of	of	ADP
dti-1295	29	11	clinical	clinical	ADJ
dti-1295	29	12	chemistry	chemistry	NOUN
dti-1295	29	13	,	,	PUNCT
dti-1295	29	14	university	university	NOUN
dti-1295	29	15	hospital	hospital	NOUN
dti-1295	29	16	of	of	ADP
dti-1295	29	17	giessen	giessen	PROPN
dti-1295	29	18	&	&	CCONJ
dti-1295	29	19	marburg	marburg	PROPN
dti-1295	29	20	,	,	PUNCT
dti-1295	29	21	d-35033	d-35033	PROPN
dti-1295	29	22	marburg	marburg	PROPN
dti-1295	29	23	,	,	PUNCT
dti-1295	29	24	germany	germany	PROPN
dti-1295	29	25	.	.	PUNCT
dti-1295	30	1	fax	fax	NOUN
dti-1295	30	2	:	:	PUNCT
dti-1295	30	3	+49	+49	NOUN
dti-1295	30	4	-	-	PUNCT
dti-1295	30	5	6421	6421	NUM
dti-1295	30	6	-	-	PUNCT
dti-1295	30	7	286	286	NUM
dti-1295	30	8	5594	5594	NUM
dti-1295	30	9	;	;	PUNCT
dti-1295	30	10	email	email	NOUN
dti-1295	30	11	:	:	PUNCT
dti-1295	30	12	thstief@med.uni-marburg.de	thstief@med.uni-marburg.de	NUM
dti-1295	30	13	please	please	INTJ
dti-1295	30	14	note	note	VERB
dti-1295	30	15	that	that	SCONJ
dti-1295	30	16	this	this	DET
dti-1295	30	17	article	article	NOUN
dti-1295	30	18	may	may	AUX
dti-1295	30	19	not	not	PART
dti-1295	30	20	be	be	AUX
dti-1295	30	21	used	use	VERB
dti-1295	30	22	for	for	ADP
dti-1295	30	23	commercial	commercial	ADJ
dti-1295	30	24	purposes	purpose	NOUN
dti-1295	30	25	.	.	PUNCT
dti-1295	31	1	for	for	ADP
dti-1295	31	2	further	further	ADJ
dti-1295	31	3	information	information	NOUN
dti-1295	31	4	please	please	INTJ
dti-1295	31	5	refer	refer	VERB
dti-1295	31	6	to	to	ADP
dti-1295	31	7	the	the	DET
dti-1295	31	8	copyright	copyright	NOUN
dti-1295	31	9	statement	statement	NOUN
dti-1295	31	10	at	at	ADP
dti-1295	31	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1295	31	12	perspectives	perspective	NOUN
dti-1295	31	13	drug	drug	NOUN
dti-1295	31	14	target	target	NOUN
dti-1295	31	15	insights	insight	NOUN
dti-1295	31	16	2006:1	2006:1	NUM
dti-1295	31	17	5	5	NUM
dti-1295	31	18	-	-	SYM
dti-1295	31	19	10	10	NUM
dti-1295	31	20	5	5	NUM
dti-1295	31	21	inhibition	inhibition	NOUN
dti-1295	31	22	of	of	ADP
dti-1295	31	23	intrinsic	intrinsic	ADJ
dti-1295	31	24	thrombin	thrombin	NOUN
dti-1295	31	25	generation	generation	NOUN
dti-1295	31	26	they	they	PRON
dti-1295	31	27	are	be	AUX
dti-1295	31	28	fast	fast	ADJ
dti-1295	31	29	and	and	CCONJ
dti-1295	31	30	economical	economical	ADJ
dti-1295	31	31	,	,	PUNCT
dti-1295	31	32	and	and	CCONJ
dti-1295	31	33	can	can	AUX
dti-1295	31	34	thus	thus	ADV
dti-1295	31	35	be	be	AUX
dti-1295	31	36	used	use	VERB
dti-1295	31	37	in	in	ADP
dti-1295	31	38	routine	routine	ADJ
dti-1295	31	39	diagnostic	diagnostic	ADJ
dti-1295	31	40	.	.	PUNCT
dti-1295	32	1	material	material	NOUN
dti-1295	32	2	and	and	CCONJ
dti-1295	32	3	methods	method	NOUN
dti-1295	32	4	inca	inca	VERB
dti-1295	32	5	coagulation	coagulation	NOUN
dti-1295	32	6	reaction	reaction	NOUN
dti-1295	32	7	time	time	NOUN
dti-1295	32	8	the	the	DET
dti-1295	32	9	inca	inca	PROPN
dti-1295	32	10	is	be	AUX
dti-1295	32	11	a	a	DET
dti-1295	32	12	new	new	ADJ
dti-1295	32	13	simple	simple	ADJ
dti-1295	32	14	global	global	ADJ
dti-1295	32	15	chromogenic	chromogenic	ADJ
dti-1295	32	16	hemostasis	hemostasis	NOUN
dti-1295	32	17	test	test	NOUN
dti-1295	32	18	that	that	PRON
dti-1295	32	19	requires	require	VERB
dti-1295	32	20	only	only	ADV
dti-1295	32	21	a	a	DET
dti-1295	32	22	two	two	NUM
dti-1295	32	23	-	-	PUNCT
dti-1295	32	24	point	point	NOUN
dti-1295	32	25	determination	determination	NOUN
dti-1295	32	26	of	of	ADP
dti-1295	32	27	thrombin	thrombin	NOUN
dti-1295	32	28	generation	generation	NOUN
dti-1295	32	29	in	in	ADP
dti-1295	32	30	the	the	DET
dti-1295	32	31	important	important	ADJ
dti-1295	32	32	ascending	ascend	VERB
dti-1295	32	33	part	part	NOUN
dti-1295	32	34	of	of	ADP
dti-1295	32	35	the	the	DET
dti-1295	32	36	thrombin	thrombin	NOUN
dti-1295	32	37	activity	activity	NOUN
dti-1295	32	38	curve	curve	NOUN
dti-1295	32	39	,	,	PUNCT
dti-1295	32	40	i.e.	i.e.	X
dti-1295	32	41	the	the	DET
dti-1295	32	42	ratio	ratio	NOUN
dti-1295	32	43	between	between	ADP
dti-1295	32	44	thrombin	thrombin	NOUN
dti-1295	32	45	at	at	ADP
dti-1295	32	46	a	a	DET
dti-1295	32	47	second	second	ADJ
dti-1295	32	48	time	time	NOUN
dti-1295	32	49	point	point	NOUN
dti-1295	32	50	divided	divide	VERB
dti-1295	32	51	by	by	ADP
dti-1295	32	52	thrombin	thrombin	NOUN
dti-1295	32	53	at	at	ADP
dti-1295	32	54	a	a	DET
dti-1295	32	55	fi	fi	NOUN
dti-1295	32	56	rst	rst	NOUN
dti-1295	32	57	time	time	NOUN
dti-1295	32	58	point	point	NOUN
dti-1295	32	59	should	should	AUX
dti-1295	32	60	be	be	AUX
dti-1295	32	61	>	>	X
dti-1295	33	1	1	1	NUM
dti-1295	33	2	.	.	X
dti-1295	33	3	50	50	NUM
dti-1295	33	4	µl	µl	ADP
dti-1295	33	5	unfrozen	unfrozen	NOUN
dti-1295	33	6	plasma	plasma	NOUN
dti-1295	33	7	(	(	PUNCT
dti-1295	33	8	1	1	NUM
dti-1295	33	9	part	part	NOUN
dti-1295	33	10	106	106	NUM
dti-1295	33	11	mm	mm	NOUN
dti-1295	33	12	citrate	citrate	NOUN
dti-1295	33	13	+	+	CCONJ
dti-1295	33	14	9	9	NUM
dti-1295	33	15	parts	part	NOUN
dti-1295	33	16	of	of	ADP
dti-1295	33	17	venous	venous	ADJ
dti-1295	33	18	blood	blood	NOUN
dti-1295	33	19	;	;	PUNCT
dti-1295	33	20	centrifuged	centrifuge	VERB
dti-1295	33	21	at	at	ADP
dti-1295	33	22	2800	2800	NUM
dti-1295	33	23	g	g	NOUN
dti-1295	33	24	(	(	PUNCT
dti-1295	33	25	4000	4000	NUM
dti-1295	33	26	rotations	rotation	NOUN
dti-1295	33	27	per	per	ADP
dti-1295	33	28	minute	minute	NOUN
dti-1295	33	29	at	at	ADP
dti-1295	33	30	23	23	NUM
dti-1295	33	31	°	°	NOUN
dti-1295	33	32	c	c	NOUN
dti-1295	33	33	)	)	PUNCT
dti-1295	33	34	are	be	AUX
dti-1295	33	35	pipetted	pipette	VERB
dti-1295	33	36	into	into	ADP
dti-1295	33	37	flat	flat	ADJ
dti-1295	33	38	bottom	bottom	NOUN
dti-1295	33	39	polystyrole	polystyrole	ADJ
dti-1295	33	40	microtiter	microtiter	NOUN
dti-1295	33	41	plate	plate	NOUN
dti-1295	33	42	wells	well	NOUN
dti-1295	33	43	(	(	PUNCT
dti-1295	33	44	f	f	X
dti-1295	33	45	-	-	PUNCT
dti-1295	33	46	wells	wells	PROPN
dti-1295	33	47	,	,	PUNCT
dti-1295	33	48	polysorp	polysorp	PROPN
dti-1295	33	49	®	®	PROPN
dti-1295	33	50	,	,	PUNCT
dti-1295	33	51	nunc	nunc	PROPN
dti-1295	33	52	,	,	PUNCT
dti-1295	33	53	wiesbaden	wiesbaden	PROPN
dti-1295	33	54	,	,	PUNCT
dti-1295	33	55	germany	germany	PROPN
dti-1295	33	56	;	;	PUNCT
dti-1295	33	57	article	article	PROPN
dti-1295	33	58	nr	nr	PROPN
dti-1295	33	59	.	.	PROPN
dti-1295	33	60	446140	446140	NUM
dti-1295	33	61	)	)	PUNCT
dti-1295	33	62	.	.	PUNCT
dti-1295	34	1	the	the	DET
dti-1295	34	2	inca	inca	PROPN
dti-1295	34	3	is	be	AUX
dti-1295	34	4	started	start	VERB
dti-1295	34	5	by	by	ADP
dti-1295	34	6	addition	addition	NOUN
dti-1295	34	7	of	of	ADP
dti-1295	34	8	5	5	NUM
dti-1295	34	9	µl	µl	ADP
dti-1295	34	10	sio2	sio2	PROPN
dti-1295	34	11	/	/	SYM
dti-1295	34	12	cacl2	cacl2	NOUN
dti-1295	34	13	reagent	reagent	NOUN
dti-1295	34	14	(	(	PUNCT
dti-1295	34	15	freshly	freshly	ADV
dti-1295	34	16	with	with	ADP
dti-1295	34	17	278	278	NUM
dti-1295	34	18	mm	mm	NOUN
dti-1295	34	19	cacl2	cacl2	NOUN
dti-1295	34	20	1:10	1:10	NUM
dti-1295	34	21	diluted	dilute	VERB
dti-1295	34	22	pathromtin	pathromtin	PROPN
dti-1295	34	23	sl	sl	PROPN
dti-1295	34	24	®	®	PROPN
dti-1295	34	25	,	,	PUNCT
dti-1295	34	26	dadebehring	dadebehring	NOUN
dti-1295	34	27	,	,	PUNCT
dti-1295	34	28	marburg	marburg	PROPN
dti-1295	34	29	,	,	PUNCT
dti-1295	34	30	germany	germany	PROPN
dti-1295	34	31	)	)	PUNCT
dti-1295	34	32	.	.	PUNCT
dti-1295	35	1	always	always	ADV
dti-1295	35	2	h2o	h2o	PROPN
dti-1295	35	3	-	-	PUNCT
dti-1295	35	4	rinsed	rinse	VERB
dti-1295	35	5	completely	completely	ADV
dti-1295	35	6	emptied	empty	VERB
dti-1295	35	7	new	new	ADJ
dti-1295	35	8	disposable	disposable	ADJ
dti-1295	35	9	polypropylene	polypropylene	NOUN
dti-1295	35	10	tips	tip	NOUN
dti-1295	35	11	for	for	ADP
dti-1295	35	12	the	the	DET
dti-1295	35	13	eppendorf	eppendorf	ADJ
dti-1295	35	14	-	-	PUNCT
dti-1295	35	15	multipette	multipette	NOUN
dti-1295	35	16	®	®	NOUN
dti-1295	35	17	are	be	AUX
dti-1295	35	18	used	use	VERB
dti-1295	35	19	:	:	PUNCT
dti-1295	35	20	if	if	SCONJ
dti-1295	35	21	this	this	DET
dti-1295	35	22	disposable	disposable	ADJ
dti-1295	35	23	tip	tip	NOUN
dti-1295	35	24	of	of	ADP
dti-1295	35	25	the	the	DET
dti-1295	35	26	multipette	multipette	NOUN
dti-1295	35	27	for	for	ADP
dti-1295	35	28	addition	addition	NOUN
dti-1295	35	29	of	of	ADP
dti-1295	35	30	the	the	DET
dti-1295	35	31	inca	inca	NOUN
dti-1295	35	32	-	-	PUNCT
dti-1295	35	33	activator	activator	NOUN
dti-1295	35	34	to	to	ADP
dti-1295	35	35	the	the	DET
dti-1295	35	36	reaction	reaction	NOUN
dti-1295	35	37	well	well	ADV
dti-1295	35	38	is	be	AUX
dti-1295	35	39	not	not	PART
dti-1295	35	40	rinsed	rinse	VERB
dti-1295	35	41	,	,	PUNCT
dti-1295	35	42	the	the	DET
dti-1295	35	43	intrinsic	intrinsic	ADJ
dti-1295	35	44	thrombin	thrombin	NOUN
dti-1295	35	45	generation	generation	NOUN
dti-1295	35	46	is	be	AUX
dti-1295	35	47	strongly	strongly	ADV
dti-1295	35	48	inhibited	inhibit	VERB
dti-1295	35	49	;	;	PUNCT
dti-1295	35	50	some	some	DET
dti-1295	35	51	releasable	releasable	ADJ
dti-1295	35	52	plastic	plastic	NOUN
dti-1295	35	53	material	material	NOUN
dti-1295	35	54	in	in	ADP
dti-1295	35	55	the	the	DET
dti-1295	35	56	new	new	ADJ
dti-1295	35	57	tip	tip	NOUN
dti-1295	35	58	seems	seem	VERB
dti-1295	35	59	to	to	PART
dti-1295	35	60	act	act	VERB
dti-1295	35	61	like	like	ADP
dti-1295	35	62	a	a	DET
dti-1295	35	63	heparinoid	heparinoid	NOUN
dti-1295	35	64	;	;	PUNCT
dti-1295	35	65	if	if	SCONJ
dti-1295	35	66	the	the	DET
dti-1295	35	67	untreated	untreated	ADJ
dti-1295	35	68	polystyrole	polystyrole	NOUN
dti-1295	35	69	f	f	X
dti-1295	35	70	-	-	PUNCT
dti-1295	35	71	well	well	PROPN
dti-1295	35	72	plate	plate	NOUN
dti-1295	35	73	(	(	PUNCT
dti-1295	35	74	polysorp	polysorp	PROPN
dti-1295	35	75	®	®	PROPN
dti-1295	35	76	)	)	PUNCT
dti-1295	35	77	is	be	AUX
dti-1295	35	78	replaced	replace	VERB
dti-1295	35	79	by	by	ADP
dti-1295	35	80	an	an	DET
dti-1295	35	81	irradiated	irradiate	VERB
dti-1295	35	82	one	one	NUM
dti-1295	35	83	(	(	PUNCT
dti-1295	35	84	maxisorp	maxisorp	PROPN
dti-1295	35	85	®	®	PROPN
dti-1295	35	86	)	)	PUNCT
dti-1295	35	87	or	or	CCONJ
dti-1295	35	88	a	a	DET
dti-1295	35	89	u	u	ADJ
dti-1295	35	90	-	-	ADJ
dti-1295	35	91	well	well	ADJ
dti-1295	35	92	plate	plate	NOUN
dti-1295	35	93	(	(	PUNCT
dti-1295	35	94	for	for	ADP
dti-1295	35	95	sample	sample	NOUN
dti-1295	35	96	volumes	volume	NOUN
dti-1295	35	97	<	<	X
dti-1295	35	98	25	25	NUM
dti-1295	35	99	µl	µl	ADP
dti-1295	35	100	u	u	NOUN
dti-1295	35	101	-	-	NOUN
dti-1295	35	102	wells	well	NOUN
dti-1295	35	103	result	result	VERB
dti-1295	35	104	in	in	ADP
dti-1295	35	105	higher	high	ADJ
dti-1295	35	106	precision	precision	NOUN
dti-1295	35	107	than	than	ADP
dti-1295	35	108	f	f	NOUN
dti-1295	35	109	-	-	PUNCT
dti-1295	35	110	wells	wells	PROPN
dti-1295	35	111	)	)	PUNCT
dti-1295	35	112	,	,	PUNCT
dti-1295	35	113	then	then	ADV
dti-1295	35	114	this	this	DET
dti-1295	35	115	plastic	plastic	NOUN
dti-1295	35	116	material	material	NOUN
dti-1295	35	117	inhibits	inhibit	VERB
dti-1295	35	118	the	the	DET
dti-1295	35	119	intrinsic	intrinsic	ADJ
dti-1295	35	120	coagulation	coagulation	NOUN
dti-1295	35	121	to	to	ADP
dti-1295	35	122	some	some	DET
dti-1295	35	123	extent	extent	NOUN
dti-1295	35	124	.	.	PUNCT
dti-1295	36	1	inca	inca	NOUN
dti-1295	36	2	inhibition	inhibition	NOUN
dti-1295	36	3	by	by	ADP
dti-1295	36	4	heparins	heparin	NOUN
dti-1295	36	5	unfrozen	unfrozen	PROPN
dti-1295	36	6	pooled	pool	VERB
dti-1295	36	7	normal	normal	ADJ
dti-1295	36	8	citrated	citrate	VERB
dti-1295	36	9	plasma	plasma	NOUN
dti-1295	36	10	in	in	ADP
dti-1295	36	11	5	5	NUM
dti-1295	36	12	ml	ml	NOUN
dti-1295	36	13	polystyrole	polystyrole	PROPN
dti-1295	36	14	tubes	tube	NOUN
dti-1295	36	15	was	be	AUX
dti-1295	36	16	supplemented	supplement	VERB
dti-1295	36	17	with	with	ADP
dti-1295	36	18	0–2	0–2	NUM
dti-1295	36	19	iu/	iu/	NOUN
dti-1295	36	20	ml	ml	NOUN
dti-1295	36	21	dalteparin	dalteparin	NOUN
dti-1295	36	22	(	(	PUNCT
dti-1295	36	23	a	a	DET
dti-1295	36	24	lmwh	lmwh	NOUN
dti-1295	36	25	;	;	PUNCT
dti-1295	36	26	fragmin	fragmin	NOUN
dti-1295	36	27	p	p	PROPN
dti-1295	36	28	®	®	NOUN
dti-1295	36	29	,	,	PUNCT
dti-1295	36	30	pharmacia	pharmacia	PROPN
dti-1295	36	31	,	,	PUNCT
dti-1295	36	32	erlangen	erlangen	PROPN
dti-1295	36	33	,	,	PUNCT
dti-1295	36	34	germany	germany	PROPN
dti-1295	36	35	)	)	PUNCT
dti-1295	36	36	or	or	CCONJ
dti-1295	36	37	with	with	ADP
dti-1295	36	38	0–2	0–2	INTJ
dti-1295	36	39	iu	iu	ADP
dti-1295	36	40	/	/	SYM
dti-1295	36	41	ml	ml	VERB
dti-1295	36	42	unfractionated	unfractionate	VERB
dti-1295	36	43	heparin	heparin	NOUN
dti-1295	36	44	(	(	PUNCT
dti-1295	36	45	roche	roche	PROPN
dti-1295	36	46	,	,	PUNCT
dti-1295	36	47	basel	basel	PROPN
dti-1295	36	48	,	,	PUNCT
dti-1295	36	49	switzerland	switzerland	PROPN
dti-1295	36	50	)	)	PUNCT
dti-1295	36	51	and	and	CCONJ
dti-1295	36	52	kept	keep	VERB
dti-1295	36	53	at	at	ADP
dti-1295	36	54	23	23	NUM
dti-1295	36	55	°	°	NOUN
dti-1295	36	56	c	c	NOUN
dti-1295	36	57	.	.	PROPN
dti-1295	36	58	50	50	NUM
dti-1295	36	59	µl	µl	ADP
dti-1295	36	60	samples	sample	NOUN
dti-1295	36	61	were	be	AUX
dti-1295	36	62	pipetted	pipette	VERB
dti-1295	36	63	into	into	ADP
dti-1295	36	64	f	f	PROPN
dti-1295	36	65	-	-	PUNCT
dti-1295	36	66	wells	wells	PROPN
dti-1295	36	67	,	,	PUNCT
dti-1295	36	68	and	and	CCONJ
dti-1295	36	69	the	the	DET
dti-1295	36	70	inca	inca	NOUN
dti-1295	36	71	was	be	AUX
dti-1295	36	72	started	start	VERB
dti-1295	36	73	by	by	ADP
dti-1295	36	74	addition	addition	NOUN
dti-1295	36	75	of	of	ADP
dti-1295	36	76	5	5	NUM
dti-1295	36	77	µl	µl	NOUN
dti-1295	36	78	sio2/	sio2/	PROPN
dti-1295	36	79	cacl2	cacl2	NOUN
dti-1295	36	80	reagent	reagent	NOUN
dti-1295	36	81	.	.	PUNCT
dti-1295	37	1	after	after	ADP
dti-1295	37	2	3	3	NUM
dti-1295	37	3	min	min	NOUN
dti-1295	37	4	coagulation	coagulation	NOUN
dti-1295	37	5	reaction	reaction	NOUN
dti-1295	37	6	time	time	NOUN
dti-1295	37	7	(	(	PUNCT
dti-1295	37	8	a	a	DET
dti-1295	37	9	crt	crt	NOUN
dti-1295	37	10	of	of	ADP
dti-1295	37	11	3	3	NUM
dti-1295	37	12	min	min	NOUN
dti-1295	37	13	is	be	AUX
dti-1295	37	14	the	the	DET
dti-1295	37	15	initial	initial	ADJ
dti-1295	37	16	time	time	NOUN
dti-1295	37	17	point	point	NOUN
dti-1295	37	18	of	of	ADP
dti-1295	37	19	thrombin	thrombin	NOUN
dti-1295	37	20	generation	generation	NOUN
dti-1295	37	21	)	)	PUNCT
dti-1295	37	22	at	at	ADP
dti-1295	37	23	37	37	NUM
dti-1295	37	24	°	°	ADP
dti-1295	37	25	c	c	NOUN
dti-1295	37	26	in	in	ADP
dti-1295	37	27	the	the	DET
dti-1295	37	28	water	water	NOUN
dti-1295	37	29	-	-	PUNCT
dti-1295	37	30	bath	bath	NOUN
dti-1295	37	31	,	,	PUNCT
dti-1295	37	32	100	100	NUM
dti-1295	37	33	µl	µl	ADP
dti-1295	37	34	2.5	2.5	NUM
dti-1295	37	35	m	m	NOUN
dti-1295	37	36	arginine	arginine	NOUN
dti-1295	37	37	,	,	PUNCT
dti-1295	37	38	ph	ph	X
dti-1295	37	39	8.6	8.6	NUM
dti-1295	37	40	(	(	PUNCT
dti-1295	37	41	sigma	sigma	PROPN
dti-1295	37	42	,	,	PUNCT
dti-1295	37	43	deisenhofen	deisenhofen	NOUN
dti-1295	37	44	,	,	PUNCT
dti-1295	37	45	germany	germany	PROPN
dti-1295	37	46	)	)	PUNCT
dti-1295	37	47	were	be	AUX
dti-1295	37	48	added	add	VERB
dti-1295	37	49	.	.	PUNCT
dti-1295	38	1	the	the	DET
dti-1295	38	2	plate	plate	NOUN
dti-1295	38	3	was	be	AUX
dti-1295	38	4	withdrawn	withdraw	VERB
dti-1295	38	5	from	from	ADP
dti-1295	38	6	the	the	DET
dti-1295	38	7	water	water	NOUN
dti-1295	38	8	-	-	PUNCT
dti-1295	38	9	bath	bath	NOUN
dti-1295	38	10	.	.	PUNCT
dti-1295	39	1	after	after	SCONJ
dti-1295	39	2	20	20	NUM
dti-1295	39	3	min	min	NOUN
dti-1295	39	4	(	(	PUNCT
dti-1295	39	5	23	23	NUM
dti-1295	39	6	°	°	ADP
dti-1295	39	7	c	c	NOUN
dti-1295	39	8	=	=	SYM
dti-1295	39	9	rt	rt	PROPN
dti-1295	39	10	)	)	PUNCT
dti-1295	39	11	10	10	NUM
dti-1295	39	12	µl	µl	ADP
dti-1295	39	13	3.85	3.85	NUM
dti-1295	39	14	mm	mm	NOUN
dti-1295	39	15	chromogenic	chromogenic	ADJ
dti-1295	39	16	thrombin	thrombin	NOUN
dti-1295	39	17	substrate	substrate	NOUN
dti-1295	39	18	hd	hd	NOUN
dti-1295	39	19	-	-	PUNCT
dti-1295	39	20	chg	chg	NOUN
dti-1295	39	21	-	-	PUNCT
dti-1295	39	22	ala	ala	PROPN
dti-1295	39	23	-	-	PUNCT
dti-1295	39	24	arg	arg	NOUN
dti-1295	39	25	-	-	PUNCT
dti-1295	39	26	pna	pna	NOUN
dti-1295	39	27	(	(	PUNCT
dti-1295	39	28	pentapharm	pentapharm	NOUN
dti-1295	39	29	,	,	PUNCT
dti-1295	39	30	basel	basel	PROPN
dti-1295	39	31	,	,	PUNCT
dti-1295	39	32	switzerland	switzerland	PROPN
dti-1295	39	33	)	)	PUNCT
dti-1295	39	34	in	in	ADP
dti-1295	39	35	h2o	h2o	PROPN
dti-1295	39	36	were	be	AUX
dti-1295	39	37	added	add	VERB
dti-1295	39	38	and	and	CCONJ
dti-1295	39	39	∆a	∆a	PROPN
dti-1295	39	40	/	/	SYM
dti-1295	39	41	t	t	PROPN
dti-1295	39	42	was	be	AUX
dti-1295	39	43	determined	determine	VERB
dti-1295	39	44	by	by	ADP
dti-1295	39	45	a	a	DET
dti-1295	39	46	microtiterplate	microtiterplate	ADJ
dti-1295	39	47	reader	reader	NOUN
dti-1295	39	48	with	with	ADP
dti-1295	39	49	a	a	DET
dti-1295	39	50	1	1	NUM
dti-1295	39	51	ma	ma	NOUN
dti-1295	39	52	resolution	resolution	NOUN
dti-1295	39	53	(	(	PUNCT
dti-1295	39	54	milenia	milenia	NOUN
dti-1295	39	55	-	-	PUNCT
dti-1295	39	56	dpc	dpc	PROPN
dti-1295	39	57	,	,	PUNCT
dti-1295	39	58	los	los	PROPN
dti-1295	39	59	angeles	angeles	PROPN
dti-1295	39	60	,	,	PUNCT
dti-1295	39	61	usa	usa	PROPN
dti-1295	39	62	)	)	PUNCT
dti-1295	39	63	.	.	PUNCT
dti-1295	40	1	the	the	DET
dti-1295	40	2	result	result	NOUN
dti-1295	40	3	was	be	AUX
dti-1295	40	4	standardized	standardize	VERB
dti-1295	40	5	against	against	ADP
dti-1295	40	6	1	1	NUM
dti-1295	40	7	iu	iu	NOUN
dti-1295	40	8	/	/	SYM
dti-1295	40	9	ml	ml	AUX
dti-1295	40	10	iia	iia	VERB
dti-1295	40	11	in	in	ADP
dti-1295	40	12	6.7	6.7	NUM
dti-1295	40	13	%	%	NOUN
dti-1295	40	14	human	human	ADJ
dti-1295	40	15	albumin	albumin	NOUN
dti-1295	40	16	(	(	PUNCT
dti-1295	40	17	kabi	kabi	PROPN
dti-1295	40	18	,	,	PUNCT
dti-1295	40	19	stockholm	stockholm	PROPN
dti-1295	40	20	,	,	PUNCT
dti-1295	40	21	sweden	sweden	PROPN
dti-1295	40	22	)	)	PUNCT
dti-1295	40	23	replacing	replace	VERB
dti-1295	40	24	the	the	DET
dti-1295	40	25	plasma	plasma	NOUN
dti-1295	40	26	sample	sample	NOUN
dti-1295	40	27	.	.	PUNCT
dti-1295	41	1	inca	inca	PROPN
dti-1295	41	2	kinetic	kinetic	PROPN
dti-1295	41	3	in	in	ADP
dti-1295	41	4	plasma	plasma	NOUN
dti-1295	41	5	supplemented	supplement	VERB
dti-1295	41	6	with	with	ADP
dti-1295	41	7	heparins	heparin	NOUN
dti-1295	41	8	20	20	NUM
dti-1295	41	9	µl	µl	ADP
dti-1295	41	10	unfrozen	unfrozen	NOUN
dti-1295	41	11	pooled	pool	VERB
dti-1295	41	12	normal	normal	ADJ
dti-1295	41	13	plasma	plasma	NOUN
dti-1295	41	14	,	,	PUNCT
dti-1295	41	15	supplemented	supplement	VERB
dti-1295	41	16	with	with	ADP
dti-1295	41	17	0	0	NUM
dti-1295	41	18	iu	iu	NOUN
dti-1295	41	19	/	/	SYM
dti-1295	41	20	ml	ml	NOUN
dti-1295	41	21	,	,	PUNCT
dti-1295	41	22	0.063	0.063	NUM
dti-1295	41	23	iu	iu	NOUN
dti-1295	41	24	/	/	SYM
dti-1295	41	25	ml	ml	NOUN
dti-1295	41	26	,	,	PUNCT
dti-1295	41	27	0.13	0.13	NUM
dti-1295	41	28	iu	iu	NOUN
dti-1295	41	29	/	/	SYM
dti-1295	41	30	ml	ml	NOUN
dti-1295	41	31	,	,	PUNCT
dti-1295	41	32	0.25	0.25	NUM
dti-1295	41	33	iu	iu	NOUN
dti-1295	41	34	/	/	SYM
dti-1295	41	35	ml	ml	NOUN
dti-1295	41	36	dalteparin	dalteparin	NOUN
dti-1295	41	37	or	or	CCONJ
dti-1295	41	38	0	0	NUM
dti-1295	41	39	iu	iu	NOUN
dti-1295	41	40	/	/	SYM
dti-1295	41	41	ml	ml	PROPN
dti-1295	41	42	,	,	PUNCT
dti-1295	41	43	0.063	0.063	NUM
dti-1295	41	44	iu	iu	NOUN
dti-1295	41	45	/	/	SYM
dti-1295	41	46	ml	ml	NOUN
dti-1295	41	47	,	,	PUNCT
dti-1295	41	48	0.13	0.13	NUM
dti-1295	41	49	iu	iu	NOUN
dti-1295	41	50	/	/	SYM
dti-1295	41	51	ml	ml	NOUN
dti-1295	41	52	,	,	PUNCT
dti-1295	41	53	0.25	0.25	NUM
dti-1295	41	54	iu	iu	NOUN
dti-1295	41	55	/	/	SYM
dti-1295	41	56	ml	ml	NOUN
dti-1295	41	57	,	,	PUNCT
dti-1295	41	58	or	or	CCONJ
dti-1295	41	59	0.5	0.5	NUM
dti-1295	41	60	iu	iu	NOUN
dti-1295	41	61	/	/	SYM
dti-1295	41	62	ml	ml	VERB
dti-1295	41	63	unfractionated	unfractionate	VERB
dti-1295	41	64	heparin	heparin	NOUN
dti-1295	41	65	were	be	AUX
dti-1295	41	66	incubated	incubate	VERB
dti-1295	41	67	in	in	ADP
dti-1295	41	68	u	u	NOUN
dti-1295	41	69	-	-	NOUN
dti-1295	41	70	wells	wells	PROPN
dti-1295	41	71	(	(	PUNCT
dti-1295	41	72	nunc	nunc	PROPN
dti-1295	41	73	)	)	PUNCT
dti-1295	41	74	with	with	ADP
dti-1295	41	75	2	2	NUM
dti-1295	41	76	µl	µl	ADP
dti-1295	41	77	sio2	sio2	PROPN
dti-1295	41	78	/	/	SYM
dti-1295	41	79	cacl2	cacl2	NOUN
dti-1295	41	80	reagent	reagent	NOUN
dti-1295	41	81	.	.	PUNCT
dti-1295	42	1	after	after	ADP
dti-1295	42	2	0–30	0–30	PROPN
dti-1295	42	3	min	min	PROPN
dti-1295	42	4	(	(	PUNCT
dti-1295	42	5	37	37	NUM
dti-1295	42	6	°	°	NOUN
dti-1295	42	7	c	c	NOUN
dti-1295	42	8	)	)	PUNCT
dti-1295	42	9	,	,	PUNCT
dti-1295	42	10	50	50	NUM
dti-1295	42	11	µl	µl	ADP
dti-1295	42	12	2.5	2.5	NUM
dti-1295	42	13	m	m	NOUN
dti-1295	42	14	arginine	arginine	NOUN
dti-1295	42	15	,	,	PUNCT
dti-1295	42	16	ph	ph	NOUN
dti-1295	42	17	8.6	8.6	NUM
dti-1295	42	18	,	,	PUNCT
dti-1295	42	19	were	be	AUX
dti-1295	42	20	added	add	VERB
dti-1295	42	21	.	.	PUNCT
dti-1295	43	1	the	the	DET
dti-1295	43	2	plate	plate	NOUN
dti-1295	43	3	was	be	AUX
dti-1295	43	4	withdrawn	withdraw	VERB
dti-1295	43	5	from	from	ADP
dti-1295	43	6	the	the	DET
dti-1295	43	7	water	water	NOUN
dti-1295	43	8	-	-	PUNCT
dti-1295	43	9	bath	bath	NOUN
dti-1295	43	10	.	.	PUNCT
dti-1295	44	1	after	after	SCONJ
dti-1295	44	2	20	20	NUM
dti-1295	44	3	min	min	NOUN
dti-1295	44	4	(	(	PUNCT
dti-1295	44	5	23	23	NUM
dti-1295	44	6	°	°	NOUN
dti-1295	44	7	c	c	NOUN
dti-1295	44	8	)	)	PUNCT
dti-1295	44	9	20	20	NUM
dti-1295	44	10	µl	µl	ADP
dti-1295	44	11	0.77	0.77	NUM
dti-1295	44	12	mm	mm	NOUN
dti-1295	44	13	chromogenic	chromogenic	ADJ
dti-1295	44	14	thrombin	thrombin	NOUN
dti-1295	44	15	substrate	substrate	NOUN
dti-1295	44	16	in	in	ADP
dti-1295	44	17	2	2	NUM
dti-1295	44	18	m	m	NOUN
dti-1295	44	19	arginine	arginine	NOUN
dti-1295	44	20	was	be	AUX
dti-1295	44	21	added	add	VERB
dti-1295	44	22	and	and	CCONJ
dti-1295	44	23	the	the	DET
dti-1295	44	24	linear	linear	ADJ
dti-1295	44	25	∆a	∆a	PROPN
dti-1295	44	26	/	/	SYM
dti-1295	44	27	t	t	PROPN
dti-1295	44	28	(	(	PUNCT
dti-1295	44	29	rt	rt	PROPN
dti-1295	44	30	)	)	PUNCT
dti-1295	44	31	was	be	AUX
dti-1295	44	32	determined	determine	VERB
dti-1295	44	33	.	.	PUNCT
dti-1295	45	1	inca	inca	NOUN
dti-1295	45	2	inhibition	inhibition	NOUN
dti-1295	45	3	by	by	ADP
dti-1295	45	4	aprotinin	aprotinin	PROPN
dti-1295	45	5	unfrozen	unfrozen	PROPN
dti-1295	45	6	pooled	pool	VERB
dti-1295	45	7	normal	normal	ADJ
dti-1295	45	8	plasma	plasma	NOUN
dti-1295	45	9	in	in	ADP
dti-1295	45	10	polystyrole	polystyrole	PROPN
dti-1295	45	11	tubes	tube	NOUN
dti-1295	45	12	was	be	AUX
dti-1295	45	13	supplemented	supplement	VERB
dti-1295	45	14	with	with	ADP
dti-1295	45	15	0–400	0–400	NOUN
dti-1295	45	16	kiu	kiu	PROPN
dti-1295	45	17	/	/	SYM
dti-1295	45	18	ml	ml	PROPN
dti-1295	45	19	aprotinin	aprotinin	NOUN
dti-1295	45	20	(	(	PUNCT
dti-1295	45	21	bayer	bayer	PROPN
dti-1295	45	22	,	,	PUNCT
dti-1295	45	23	leverkusen	leverkusen	PROPN
dti-1295	45	24	,	,	PUNCT
dti-1295	45	25	germany	germany	PROPN
dti-1295	45	26	)	)	PUNCT
dti-1295	45	27	.	.	PUNCT
dti-1295	46	1	the	the	DET
dti-1295	46	2	inca	inca	PROPN
dti-1295	46	3	was	be	AUX
dti-1295	46	4	performed	perform	VERB
dti-1295	46	5	with	with	ADP
dti-1295	46	6	20	20	NUM
dti-1295	46	7	µl	µl	ADP
dti-1295	46	8	plasma	plasma	NOUN
dti-1295	46	9	samples	sample	NOUN
dti-1295	46	10	in	in	ADP
dti-1295	46	11	u	u	NOUN
dti-1295	46	12	-	-	NOUN
dti-1295	46	13	wells	well	NOUN
dti-1295	46	14	and	and	CCONJ
dti-1295	46	15	2	2	NUM
dti-1295	46	16	µl	µl	ADP
dti-1295	46	17	inca	inca	NOUN
dti-1295	46	18	-	-	PUNCT
dti-1295	46	19	activator	activator	NOUN
dti-1295	46	20	.	.	PUNCT
dti-1295	47	1	after	after	ADP
dti-1295	47	2	0–30	0–30	PROPN
dti-1295	47	3	min	min	PROPN
dti-1295	47	4	(	(	PUNCT
dti-1295	47	5	37	37	NUM
dti-1295	47	6	°	°	NOUN
dti-1295	47	7	c	c	NOUN
dti-1295	47	8	)	)	PUNCT
dti-1295	47	9	,	,	PUNCT
dti-1295	47	10	50	50	NUM
dti-1295	47	11	µl	µl	ADP
dti-1295	47	12	2.5	2.5	NUM
dti-1295	47	13	m	m	NOUN
dti-1295	47	14	arginine	arginine	NOUN
dti-1295	47	15	,	,	PUNCT
dti-1295	47	16	ph	ph	NOUN
dti-1295	47	17	8.6	8.6	NUM
dti-1295	47	18	,	,	PUNCT
dti-1295	47	19	were	be	AUX
dti-1295	47	20	added	add	VERB
dti-1295	47	21	.	.	PUNCT
dti-1295	48	1	after	after	SCONJ
dti-1295	48	2	20	20	NUM
dti-1295	48	3	min	min	NOUN
dti-1295	48	4	(	(	PUNCT
dti-1295	48	5	rt	rt	PROPN
dti-1295	48	6	)	)	PUNCT
dti-1295	48	7	20	20	NUM
dti-1295	48	8	µl	µl	ADP
dti-1295	48	9	0.77	0.77	NUM
dti-1295	48	10	mm	mm	NOUN
dti-1295	48	11	chromogenic	chromogenic	ADJ
dti-1295	48	12	substrate	substrate	NOUN
dti-1295	48	13	in	in	ADP
dti-1295	48	14	2	2	NUM
dti-1295	48	15	m	m	NOUN
dti-1295	48	16	arginine	arginine	NOUN
dti-1295	48	17	was	be	AUX
dti-1295	48	18	added	add	VERB
dti-1295	48	19	and	and	CCONJ
dti-1295	48	20	the	the	DET
dti-1295	48	21	linear	linear	ADJ
dti-1295	48	22	∆a	∆a	PROPN
dti-1295	48	23	/	/	SYM
dti-1295	48	24	t	t	PROPN
dti-1295	48	25	(	(	PUNCT
dti-1295	48	26	rt	rt	PROPN
dti-1295	48	27	)	)	PUNCT
dti-1295	48	28	was	be	AUX
dti-1295	48	29	determined	determine	VERB
dti-1295	48	30	.	.	PUNCT
dti-1295	49	1	additionly	additionly	ADV
dti-1295	49	2	,	,	PUNCT
dti-1295	49	3	the	the	DET
dti-1295	49	4	aptt	aptt	NOUN
dti-1295	49	5	of	of	ADP
dti-1295	49	6	the	the	DET
dti-1295	49	7	aprotinin	aprotinin	NOUN
dti-1295	49	8	-	-	PUNCT
dti-1295	49	9	supplemented	supplement	VERB
dti-1295	49	10	plasma	plasma	NOUN
dti-1295	49	11	samples	sample	NOUN
dti-1295	49	12	was	be	AUX
dti-1295	49	13	measured	measure	VERB
dti-1295	49	14	by	by	ADP
dti-1295	49	15	a	a	DET
dti-1295	49	16	behring	behring	NOUN
dti-1295	49	17	coagulation	coagulation	NOUN
dti-1295	49	18	timer	timer	NOUN
dti-1295	49	19	®	®	PROPN
dti-1295	49	20	.	.	PUNCT
dti-1295	50	1	inca	inca	PROPN
dti-1295	50	2	inhibition	inhibition	NOUN
dti-1295	50	3	by	by	ADP
dti-1295	50	4	arginine	arginine	NOUN
dti-1295	50	5	unfrozen	unfrozen	PROPN
dti-1295	50	6	pooled	pool	VERB
dti-1295	50	7	normal	normal	ADJ
dti-1295	50	8	plasma	plasma	NOUN
dti-1295	50	9	in	in	ADP
dti-1295	50	10	polystyrole	polystyrole	PROPN
dti-1295	50	11	tubes	tube	NOUN
dti-1295	50	12	was	be	AUX
dti-1295	50	13	supplemented	supplement	VERB
dti-1295	50	14	with	with	ADP
dti-1295	50	15	0–40	0–40	PROPN
dti-1295	50	16	mm	mm	PROPN
dti-1295	50	17	arginine	arginine	NOUN
dti-1295	50	18	(	(	PUNCT
dti-1295	50	19	braun	braun	NOUN
dti-1295	50	20	,	,	PUNCT
dti-1295	50	21	melsungen	melsungen	PROPN
dti-1295	50	22	,	,	PUNCT
dti-1295	50	23	germany	germany	PROPN
dti-1295	50	24	)	)	PUNCT
dti-1295	50	25	or	or	CCONJ
dti-1295	50	26	alkaline	alkaline	NOUN
dti-1295	50	27	arginine	arginine	NOUN
dti-1295	50	28	(	(	PUNCT
dti-1295	50	29	ph	ph	NOUN
dti-1295	50	30	=	=	SYM
dti-1295	50	31	8.7	8.7	NUM
dti-1295	50	32	;	;	PUNCT
dti-1295	50	33	sigma	sigma	PROPN
dti-1295	50	34	)	)	PUNCT
dti-1295	50	35	.	.	PUNCT
dti-1295	51	1	50	50	NUM
dti-1295	51	2	µl	µl	ADP
dti-1295	51	3	samples	sample	NOUN
dti-1295	51	4	were	be	AUX
dti-1295	51	5	tested	test	VERB
dti-1295	51	6	in	in	ADP
dti-1295	51	7	the	the	DET
dti-1295	51	8	inca	inca	NOUN
dti-1295	51	9	(	(	PUNCT
dti-1295	51	10	f	f	X
dti-1295	51	11	-	-	PUNCT
dti-1295	51	12	wells	wells	PROPN
dti-1295	51	13	)	)	PUNCT
dti-1295	51	14	.	.	PUNCT
dti-1295	52	1	infl	infl	PROPN
dti-1295	52	2	uence	uence	PROPN
dti-1295	52	3	of	of	ADP
dti-1295	52	4	fi	fi	PROPN
dti-1295	52	5	brin	brin	NOUN
dti-1295	52	6	on	on	ADP
dti-1295	52	7	anticoagulants	anticoagulant	NOUN
dti-1295	52	8	in	in	ADP
dti-1295	52	9	inca	inca	PROPN
dti-1295	52	10	unfrozen	unfrozen	PROPN
dti-1295	52	11	pooled	pool	VERB
dti-1295	52	12	normal	normal	ADJ
dti-1295	52	13	plasma	plasma	NOUN
dti-1295	52	14	with	with	ADP
dti-1295	52	15	2.8	2.8	NUM
dti-1295	52	16	g	g	NOUN
dti-1295	52	17	/	/	SYM
dti-1295	52	18	l	l	NOUN
dti-1295	52	19	fi	fi	NOUN
dti-1295	52	20	brinogen	brinogen	PROPN
dti-1295	52	21	was	be	AUX
dti-1295	52	22	unsupplemented	unsupplemente	VERB
dti-1295	52	23	and	and	CCONJ
dti-1295	52	24	supplemented	supplement	VERB
dti-1295	52	25	with	with	ADP
dti-1295	52	26	purifi	purifi	PROPN
dti-1295	52	27	ed	ed	PROPN
dti-1295	52	28	human	human	PROPN
dti-1295	52	29	fi	fi	NOUN
dti-1295	52	30	brinogen	brinogen	PROPN
dti-1295	52	31	(	(	PUNCT
dti-1295	52	32	haemocomplettan	haemocomplettan	PROPN
dti-1295	52	33	,	,	PUNCT
dti-1295	52	34	aventis	aventis	PROPN
dti-1295	52	35	,	,	PUNCT
dti-1295	52	36	frankfurt	frankfurt	PROPN
dti-1295	52	37	,	,	PUNCT
dti-1295	52	38	germany	germany	PROPN
dti-1295	52	39	;	;	PUNCT
dti-1295	52	40	the	the	DET
dti-1295	52	41	preparation	preparation	NOUN
dti-1295	52	42	drug	drug	NOUN
dti-1295	52	43	target	target	NOUN
dti-1295	52	44	insights	insight	NOUN
dti-1295	52	45	2006:16	2006:16	NUM
dti-1295	52	46	thomas	thomas	PROPN
dti-1295	52	47	w.	w.	PROPN
dti-1295	52	48	stief	stief	PROPN
dti-1295	52	49	contained	contain	VERB
dti-1295	52	50	about	about	ADV
dti-1295	52	51	1	1	NUM
dti-1295	52	52	%	%	NOUN
dti-1295	52	53	soluble	soluble	ADJ
dti-1295	52	54	fi	fi	NOUN
dti-1295	52	55	brin	brin	PROPN
dti-1295	53	1	[	[	X
dti-1295	53	2	stief	stief	NOUN
dti-1295	53	3	,	,	PUNCT
dti-1295	53	4	2000	2000	NUM
dti-1295	53	5	]	]	PUNCT
dti-1295	53	6	that	that	PRON
dti-1295	53	7	might	might	AUX
dti-1295	53	8	act	act	VERB
dti-1295	53	9	as	as	ADP
dti-1295	53	10	antithrombin	antithrombin	NOUN
dti-1295	53	11	i	i	PROPN
dti-1295	54	1	[	[	X
dti-1295	54	2	mosesson	mosesson	NOUN
dti-1295	54	3	,	,	PUNCT
dti-1295	54	4	2005	2005	NUM
dti-1295	54	5	]	]	PUNCT
dti-1295	54	6	)	)	PUNCT
dti-1295	54	7	to	to	ADP
dti-1295	54	8	a	a	DET
dti-1295	54	9	fi	fi	NOUN
dti-1295	54	10	nal	nal	ADJ
dti-1295	54	11	active	active	ADJ
dti-1295	54	12	fi	fi	NOUN
dti-1295	54	13	brinogen	brinogen	NOUN
dti-1295	54	14	concentration	concentration	NOUN
dti-1295	54	15	of	of	ADP
dti-1295	54	16	4.0	4.0	NUM
dti-1295	54	17	g	g	NOUN
dti-1295	54	18	/	/	SYM
dti-1295	54	19	l.	l.	NOUN
dti-1295	54	20	the	the	DET
dti-1295	54	21	plasmas	plasma	NOUN
dti-1295	54	22	were	be	AUX
dti-1295	54	23	then	then	ADV
dti-1295	54	24	unsupplemented	unsupplemente	VERB
dti-1295	54	25	or	or	CCONJ
dti-1295	54	26	supplemented	supplement	VERB
dti-1295	54	27	with	with	ADP
dti-1295	54	28	0.01	0.01	NUM
dti-1295	54	29	iu	iu	NOUN
dti-1295	54	30	/	/	SYM
dti-1295	54	31	ml	ml	NOUN
dti-1295	54	32	dalteparin	dalteparin	NOUN
dti-1295	54	33	,	,	PUNCT
dti-1295	54	34	0.02	0.02	NUM
dti-1295	54	35	iu	iu	NOUN
dti-1295	54	36	/	/	SYM
dti-1295	54	37	ml	ml	NOUN
dti-1295	54	38	heparin	heparin	NOUN
dti-1295	54	39	,	,	PUNCT
dti-1295	54	40	25	25	NUM
dti-1295	54	41	kiu	kiu	NOUN
dti-1295	54	42	/	/	SYM
dti-1295	54	43	ml	ml	NOUN
dti-1295	54	44	aprotinin	aprotinin	NOUN
dti-1295	54	45	,	,	PUNCT
dti-1295	54	46	or	or	CCONJ
dti-1295	54	47	12	12	NUM
dti-1295	54	48	mm	mm	NOUN
dti-1295	54	49	arginine	arginine	NOUN
dti-1295	54	50	.	.	PUNCT
dti-1295	55	1	the	the	DET
dti-1295	55	2	inca	inca	PROPN
dti-1295	55	3	was	be	AUX
dti-1295	55	4	performed	perform	VERB
dti-1295	55	5	as	as	ADP
dti-1295	55	6	described	describe	VERB
dti-1295	55	7	above	above	ADV
dti-1295	55	8	.	.	PUNCT
dti-1295	56	1	addition	addition	NOUN
dti-1295	56	2	of	of	ADP
dti-1295	56	3	0.1	0.1	NUM
dti-1295	56	4	%	%	NOUN
dti-1295	56	5	triton	triton	NOUN
dti-1295	56	6	x	x	SYM
dti-1295	56	7	100	100	NUM
dti-1295	56	8	®	®	NOUN
dti-1295	56	9	(	(	PUNCT
dti-1295	56	10	sigma	sigma	PROPN
dti-1295	56	11	)	)	PUNCT
dti-1295	56	12	fi	fi	NOUN
dti-1295	56	13	nal	nal	ADJ
dti-1295	56	14	test	test	NOUN
dti-1295	56	15	concentration	concentration	NOUN
dti-1295	56	16	accelerates	accelerate	VERB
dti-1295	56	17	the	the	DET
dti-1295	56	18	decrease	decrease	NOUN
dti-1295	56	19	of	of	ADP
dti-1295	56	20	the	the	DET
dti-1295	56	21	fi	fi	NOUN
dti-1295	56	22	brin	brin	ADV
dti-1295	56	23	-	-	PUNCT
dti-1295	56	24	related	relate	VERB
dti-1295	56	25	turbidity	turbidity	NOUN
dti-1295	56	26	about	about	ADP
dti-1295	56	27	7fold	7fold	NUM
dti-1295	56	28	,	,	PUNCT
dti-1295	56	29	i.e.	i.e.	X
dti-1295	56	30	instead	instead	ADV
dti-1295	56	31	of	of	ADP
dti-1295	56	32	20	20	NUM
dti-1295	56	33	min	min	NOUN
dti-1295	56	34	arginine	arginine	NOUN
dti-1295	56	35	reaction	reaction	NOUN
dti-1295	56	36	time	time	NOUN
dti-1295	56	37	3	3	NUM
dti-1295	56	38	min	min	NOUN
dti-1295	56	39	is	be	AUX
dti-1295	56	40	suffi	suffi	NOUN
dti-1295	56	41	cient	cient	NOUN
dti-1295	56	42	before	before	ADP
dti-1295	56	43	starting	start	VERB
dti-1295	56	44	the	the	DET
dti-1295	56	45	iia	iia	NOUN
dti-1295	56	46	detection	detection	NOUN
dti-1295	56	47	phase	phase	NOUN
dti-1295	56	48	of	of	ADP
dti-1295	56	49	the	the	DET
dti-1295	56	50	assay	assay	NOUN
dti-1295	56	51	.	.	PUNCT
dti-1295	57	1	a	a	DET
dti-1295	57	2	turbidity	turbidity	NOUN
dti-1295	57	3	increase	increase	NOUN
dti-1295	57	4	in	in	ADP
dti-1295	57	5	plasma	plasma	NOUN
dti-1295	57	6	occurs	occur	VERB
dti-1295	57	7	within	within	ADP
dti-1295	57	8	minutes	minute	NOUN
dti-1295	57	9	,	,	PUNCT
dti-1295	57	10	if	if	SCONJ
dti-1295	57	11	the	the	DET
dti-1295	57	12	fi	fi	NOUN
dti-1295	57	13	nal	nal	ADJ
dti-1295	57	14	thrombin	thrombin	NOUN
dti-1295	57	15	activity	activity	NOUN
dti-1295	57	16	exceeds	exceed	VERB
dti-1295	57	17	0.02	0.02	NUM
dti-1295	57	18	iu	iu	NOUN
dti-1295	57	19	/	/	SYM
dti-1295	57	20	ml	ml	NOUN
dti-1295	58	1	[	[	X
dti-1295	58	2	stief	stief	NOUN
dti-1295	58	3	,	,	PUNCT
dti-1295	58	4	2007	2007	NUM
dti-1295	58	5	in	in	ADP
dti-1295	58	6	press	press	NOUN
dti-1295	58	7	]	]	PUNCT
dti-1295	58	8	.	.	PUNCT
dti-1295	59	1	results	result	VERB
dti-1295	59	2	the	the	DET
dti-1295	59	3	action	action	NOUN
dti-1295	59	4	of	of	ADP
dti-1295	59	5	heparins	heparin	NOUN
dti-1295	59	6	on	on	ADP
dti-1295	59	7	inca	inca	PROPN
dti-1295	59	8	is	be	AUX
dti-1295	59	9	shown	show	VERB
dti-1295	59	10	in	in	ADP
dti-1295	59	11	figure	figure	NOUN
dti-1295	59	12	1	1	NUM
dti-1295	59	13	.	.	PUNCT
dti-1295	60	1	the	the	DET
dti-1295	60	2	50	50	NUM
dti-1295	60	3	%	%	NOUN
dti-1295	60	4	inhibitory	inhibitory	ADJ
dti-1295	60	5	concentrations	concentration	NOUN
dti-1295	60	6	(	(	PUNCT
dti-1295	60	7	ic50	ic50	PROPN
dti-1295	60	8	)	)	PUNCT
dti-1295	60	9	were	be	AUX
dti-1295	60	10	about	about	ADV
dti-1295	60	11	0.01	0.01	NUM
dti-1295	60	12	iu	iu	NOUN
dti-1295	60	13	/	/	SYM
dti-1295	60	14	ml	ml	X
dti-1295	60	15	for	for	ADP
dti-1295	60	16	lmwh	lmwh	NOUN
dti-1295	60	17	and	and	CCONJ
dti-1295	60	18	0.02	0.02	NUM
dti-1295	60	19	iu	iu	ADV
dti-1295	60	20	/	/	SYM
dti-1295	60	21	ml	ml	NOUN
dti-1295	60	22	for	for	ADP
dti-1295	60	23	unfractionated	unfractionate	VERB
dti-1295	60	24	heparin	heparin	NOUN
dti-1295	60	25	(	(	PUNCT
dti-1295	60	26	fig	fig	NOUN
dti-1295	60	27	.	.	PUNCT
dti-1295	61	1	1a	1a	NOUN
dti-1295	61	2	)	)	PUNCT
dti-1295	61	3	.	.	PUNCT
dti-1295	62	1	in	in	ADP
dti-1295	62	2	therapeutical	therapeutical	ADJ
dti-1295	62	3	heparin	heparin	ADJ
dti-1295	62	4	concentrations	concentration	NOUN
dti-1295	62	5	(	(	PUNCT
dti-1295	62	6	about	about	ADV
dti-1295	62	7	0.2	0.2	NUM
dti-1295	62	8	iu	iu	ADP
dti-1295	62	9	/	/	SYM
dti-1295	62	10	ml	ml	NOUN
dti-1295	62	11	)	)	PUNCT
dti-1295	62	12	,	,	PUNCT
dti-1295	62	13	0	0	NUM
dti-1295	62	14	0.01	0.01	NUM
dti-1295	62	15	0.02	0.02	NUM
dti-1295	62	16	0.03	0.03	NUM
dti-1295	62	17	0.04	0.04	NUM
dti-1295	62	18	0.05	0.05	NUM
dti-1295	62	19	0.06	0.06	NUM
dti-1295	62	20	0.07	0.07	NUM
dti-1295	62	21	0	0	NUM
dti-1295	62	22	0.05	0.05	NUM
dti-1295	62	23	0.1	0.1	NUM
dti-1295	62	24	0.1	0.1	NUM
dti-1295	62	25	5	5	NUM
dti-1295	62	26	0.2	0.2	NUM
dti-1295	62	27	0.25	0.25	NUM
dti-1295	62	28	0.3	0.3	NUM
dti-1295	62	29	heparin	heparin	ADJ
dti-1295	62	30	conc	conc	NOUN
dti-1295	62	31	.	.	PUNCT
dti-1295	63	1	[	[	X
dti-1295	63	2	iu	iu	ADP
dti-1295	63	3	/	/	SYM
dti-1295	63	4	ml	ml	VERB
dti-1295	63	5	]	]	X
dti-1295	63	6	ii	ii	PROPN
dti-1295	63	7	a	a	PRON
dti-1295	63	8	a	a	DET
dti-1295	63	9	ct	ct	NOUN
dti-1295	63	10	iv	iv	NUM
dti-1295	64	1	it	it	PRON
dti-1295	65	1	y	y	PROPN
dti-1295	65	2	3	3	NUM
dti-1295	65	3	m	m	VERB
dti-1295	65	4	in	in	ADP
dti-1295	65	5	c	c	PROPN
dti-1295	65	6	rt	rt	PROPN
dti-1295	66	1	[	[	X
dti-1295	66	2	i	i	PRON
dti-1295	66	3	u	u	NOUN
dti-1295	66	4	/m	/m	PUNCT
dti-1295	66	5	l	l	NOUN
dti-1295	66	6	]	]	PUNCT
dti-1295	66	7	figure	figure	NOUN
dti-1295	66	8	1	1	NUM
dti-1295	66	9	.	.	PUNCT
dti-1295	66	10	inhibition	inhibition	NOUN
dti-1295	66	11	of	of	ADP
dti-1295	66	12	intrinsic	intrinsic	ADJ
dti-1295	66	13	thrombin	thrombin	NOUN
dti-1295	66	14	generation	generation	NOUN
dti-1295	66	15	by	by	ADP
dti-1295	66	16	heparins	heparin	NOUN
dti-1295	66	17	.	.	PUNCT
dti-1295	67	1	figure	figure	NOUN
dti-1295	67	2	1a	1a	NOUN
dti-1295	67	3	.	.	PUNCT
dti-1295	68	1	ic50	ic50	PROPN
dti-1295	68	2	determination	determination	NOUN
dti-1295	68	3	.	.	PUNCT
dti-1295	69	1	unfrozen	unfrozen	PROPN
dti-1295	69	2	pooled	pool	VERB
dti-1295	69	3	normal	normal	ADJ
dti-1295	69	4	plasma	plasma	NOUN
dti-1295	69	5	,	,	PUNCT
dti-1295	69	6	supplemented	supplement	VERB
dti-1295	69	7	with	with	ADP
dti-1295	69	8	dalteparin	dalteparin	NOUN
dti-1295	69	9	(	(	PUNCT
dti-1295	69	10	●	●	NOUN
dti-1295	69	11	)	)	PUNCT
dti-1295	69	12	or	or	CCONJ
dti-1295	69	13	unfractionated	unfractionate	VERB
dti-1295	69	14	heparin	heparin	NOUN
dti-1295	69	15	(	(	PUNCT
dti-1295	69	16	■	■	NOUN
dti-1295	69	17	)	)	PUNCT
dti-1295	69	18	was	be	AUX
dti-1295	69	19	analyzed	analyze	VERB
dti-1295	69	20	in	in	ADP
dti-1295	69	21	the	the	DET
dti-1295	69	22	inca	inca	NOUN
dti-1295	69	23	(	(	PUNCT
dti-1295	69	24	50	50	NUM
dti-1295	69	25	µl	µl	ADP
dti-1295	69	26	sample	sample	NOUN
dti-1295	69	27	into	into	ADP
dti-1295	69	28	f	f	PROPN
dti-1295	69	29	-	-	PUNCT
dti-1295	69	30	wells	wells	PROPN
dti-1295	69	31	)	)	PUNCT
dti-1295	69	32	.	.	PUNCT
dti-1295	70	1	the	the	DET
dti-1295	70	2	inca	inca	PROPN
dti-1295	70	3	was	be	AUX
dti-1295	70	4	performed	perform	VERB
dti-1295	70	5	with	with	ADP
dti-1295	70	6	a	a	DET
dti-1295	70	7	thrombin	thrombin	NOUN
dti-1295	70	8	generation	generation	NOUN
dti-1295	70	9	time	time	NOUN
dti-1295	70	10	=	=	NOUN
dti-1295	70	11	coagulation	coagulation	NOUN
dti-1295	70	12	reaction	reaction	NOUN
dti-1295	70	13	time	time	NOUN
dti-1295	70	14	of	of	ADP
dti-1295	70	15	3	3	NUM
dti-1295	70	16	min	min	NOUN
dti-1295	70	17	(	(	PUNCT
dti-1295	70	18	initial	initial	ADJ
dti-1295	70	19	phase	phase	NOUN
dti-1295	70	20	of	of	ADP
dti-1295	70	21	thrombin	thrombin	NOUN
dti-1295	70	22	generation	generation	NOUN
dti-1295	70	23	)	)	PUNCT
dti-1295	70	24	.	.	PUNCT
dti-1295	71	1	10	10	NUM
dti-1295	71	2	µl	µl	ADP
dti-1295	71	3	3.85	3.85	NUM
dti-1295	71	4	mm	mm	NOUN
dti-1295	71	5	chg	chg	PROPN
dti-1295	71	6	-	-	PUNCT
dti-1295	71	7	ala	ala	PROPN
dti-1295	71	8	-	-	PUNCT
dti-1295	71	9	arg	arg	NOUN
dti-1295	71	10	-	-	PUNCT
dti-1295	71	11	pna	pna	NOUN
dti-1295	71	12	in	in	ADP
dti-1295	71	13	h	h	PROPN
dti-1295	71	14	2o	2o	NOUN
dti-1295	71	15	were	be	AUX
dti-1295	71	16	added	add	VERB
dti-1295	71	17	and	and	CCONJ
dti-1295	71	18	∆a	∆a	PROPN
dti-1295	71	19	/	/	SYM
dti-1295	71	20	t	t	PROPN
dti-1295	71	21	was	be	AUX
dti-1295	71	22	measured	measure	VERB
dti-1295	71	23	.	.	PUNCT
dti-1295	72	1	1	1	NUM
dti-1295	72	2	iu	iu	NOUN
dti-1295	72	3	/	/	SYM
dti-1295	72	4	ml	ml	VERB
dti-1295	72	5	iia	iia	PROPN
dti-1295	72	6	had	have	VERB
dti-1295	72	7	12.2	12.2	NUM
dti-1295	72	8	ma	ma	PROPN
dti-1295	72	9	/	/	SYM
dti-1295	72	10	min	min	PROPN
dti-1295	72	11	rt	rt	PROPN
dti-1295	72	12	.	.	PROPN
dti-1295	72	13	0	0	NUM
dti-1295	72	14	1	1	NUM
dti-1295	72	15	2	2	NUM
dti-1295	72	16	3	3	NUM
dti-1295	72	17	4	4	NUM
dti-1295	72	18	5	5	NUM
dti-1295	72	19	6	6	NUM
dti-1295	72	20	7	7	NUM
dti-1295	72	21	0	0	NUM
dti-1295	72	22	5	5	NUM
dti-1295	72	23	10	10	NUM
dti-1295	72	24	5	5	NUM
dti-1295	72	25	crt	crt	NOUN
dti-1295	72	26	[	[	X
dti-1295	72	27	min	min	X
dti-1295	72	28	]	]	X
dti-1295	72	29	iia	iia	VERB
dti-1295	72	30	a	a	DET
dti-1295	72	31	ct	ct	NOUN
dti-1295	72	32	iv	iv	NOUN
dti-1295	72	33	ity	ity	PROPN
dti-1295	72	34	[	[	X
dti-1295	72	35	i	i	PRON
dti-1295	72	36	u	u	NOUN
dti-1295	72	37	/m	/m	PUNCT
dti-1295	72	38	l	l	NOUN
dti-1295	72	39	]	]	X
dti-1295	72	40	1	1	NUM
dti-1295	72	41	20	20	NUM
dti-1295	72	42	25	25	NUM
dti-1295	72	43	30	30	NUM
dti-1295	72	44	35	35	NUM
dti-1295	72	45	figure	figure	NOUN
dti-1295	72	46	1b	1b	NUM
dti-1295	72	47	.	.	PUNCT
dti-1295	73	1	reaction	reaction	NOUN
dti-1295	73	2	kinetic	kinetic	NOUN
dti-1295	73	3	of	of	ADP
dti-1295	73	4	dalteparin	dalteparin	NOUN
dti-1295	73	5	.	.	PUNCT
dti-1295	74	1	20	20	NUM
dti-1295	74	2	µl	µl	ADP
dti-1295	74	3	unfrozen	unfrozen	NOUN
dti-1295	74	4	pooled	pool	VERB
dti-1295	74	5	normal	normal	ADJ
dti-1295	74	6	plasma	plasma	NOUN
dti-1295	74	7	,	,	PUNCT
dti-1295	74	8	supplemented	supplement	VERB
dti-1295	74	9	with	with	ADP
dti-1295	74	10	0	0	NUM
dti-1295	74	11	iu	iu	NOUN
dti-1295	74	12	/	/	SYM
dti-1295	74	13	ml	ml	NOUN
dti-1295	74	14	(	(	PUNCT
dti-1295	74	15	o	o	NOUN
dti-1295	74	16	)	)	PUNCT
dti-1295	74	17	,	,	PUNCT
dti-1295	74	18	0.063	0.063	NUM
dti-1295	74	19	iu	iu	NOUN
dti-1295	74	20	/	/	SYM
dti-1295	74	21	ml	ml	PROPN
dti-1295	74	22	(	(	PUNCT
dti-1295	74	23	■	■	NOUN
dti-1295	74	24	)	)	PUNCT
dti-1295	74	25	,	,	PUNCT
dti-1295	74	26	0.13	0.13	NUM
dti-1295	74	27	iu	iu	NOUN
dti-1295	74	28	/	/	SYM
dti-1295	74	29	ml	ml	PROPN
dti-1295	74	30	(	(	PUNCT
dti-1295	74	31	♦	♦	PROPN
dti-1295	74	32	)	)	PUNCT
dti-1295	74	33	,	,	PUNCT
dti-1295	74	34	or	or	CCONJ
dti-1295	74	35	0.25	0.25	NUM
dti-1295	74	36	iu	iu	NOUN
dti-1295	74	37	/	/	SYM
dti-1295	74	38	ml	ml	NOUN
dti-1295	74	39	(	(	PUNCT
dti-1295	74	40	▲	▲	NOUN
dti-1295	74	41	)	)	PUNCT
dti-1295	74	42	dalteparin	dalteparin	NOUN
dti-1295	74	43	was	be	AUX
dti-1295	74	44	incubated	incubate	VERB
dti-1295	74	45	with	with	ADP
dti-1295	74	46	2	2	NUM
dti-1295	74	47	µl	µl	ADP
dti-1295	74	48	sio2	sio2	PROPN
dti-1295	74	49	/	/	SYM
dti-1295	74	50	cacl2	cacl2	NOUN
dti-1295	74	51	reagent	reagent	NOUN
dti-1295	74	52	.	.	PUNCT
dti-1295	75	1	after	after	SCONJ
dti-1295	75	2	0–30	0–30	PROPN
dti-1295	75	3	min	min	PROPN
dti-1295	75	4	crt	crt	PROPN
dti-1295	75	5	at	at	ADP
dti-1295	75	6	37	37	NUM
dti-1295	75	7	°	°	ADP
dti-1295	75	8	c	c	NOUN
dti-1295	75	9	in	in	ADP
dti-1295	75	10	the	the	DET
dti-1295	75	11	water	water	NOUN
dti-1295	75	12	-	-	PUNCT
dti-1295	75	13	bath	bath	NOUN
dti-1295	75	14	50	50	NUM
dti-1295	75	15	µl	µl	ADP
dti-1295	75	16	2.5	2.5	NUM
dti-1295	75	17	m	m	NOUN
dti-1295	75	18	arginine	arginine	NOUN
dti-1295	75	19	,	,	PUNCT
dti-1295	75	20	ph	ph	NOUN
dti-1295	75	21	8.6	8.6	NUM
dti-1295	75	22	,	,	PUNCT
dti-1295	75	23	was	be	AUX
dti-1295	75	24	added	add	VERB
dti-1295	75	25	.	.	PUNCT
dti-1295	76	1	after	after	SCONJ
dti-1295	76	2	20	20	NUM
dti-1295	76	3	min	min	NOUN
dti-1295	76	4	(	(	PUNCT
dti-1295	76	5	rt	rt	PROPN
dti-1295	76	6	)	)	PUNCT
dti-1295	76	7	20	20	NUM
dti-1295	76	8	µl	µl	ADP
dti-1295	76	9	0.77	0.77	NUM
dti-1295	76	10	mm	mm	NOUN
dti-1295	76	11	chromogenic	chromogenic	ADJ
dti-1295	76	12	thrombin	thrombin	NOUN
dti-1295	76	13	substrate	substrate	NOUN
dti-1295	76	14	in	in	ADP
dti-1295	76	15	2	2	NUM
dti-1295	76	16	m	m	NOUN
dti-1295	76	17	arginine	arginine	NOUN
dti-1295	76	18	was	be	AUX
dti-1295	76	19	added	add	VERB
dti-1295	76	20	and	and	CCONJ
dti-1295	76	21	the	the	DET
dti-1295	76	22	linear	linear	ADJ
dti-1295	76	23	∆a	∆a	PROPN
dti-1295	76	24	/	/	SYM
dti-1295	76	25	t	t	PROPN
dti-1295	76	26	(	(	PUNCT
dti-1295	76	27	rt	rt	PROPN
dti-1295	76	28	)	)	PUNCT
dti-1295	76	29	was	be	AUX
dti-1295	76	30	determined	determine	VERB
dti-1295	76	31	.	.	PUNCT
dti-1295	77	1	drug	drug	NOUN
dti-1295	77	2	target	target	NOUN
dti-1295	77	3	insights	insight	NOUN
dti-1295	77	4	2006:1	2006:1	NUM
dti-1295	77	5	7	7	NUM
dti-1295	77	6	inhibition	inhibition	NOUN
dti-1295	77	7	of	of	ADP
dti-1295	77	8	intrinsic	intrinsic	ADJ
dti-1295	77	9	thrombin	thrombin	NOUN
dti-1295	77	10	generation	generation	NOUN
dti-1295	77	11	0	0	NUM
dti-1295	77	12	1	1	NUM
dti-1295	77	13	2	2	NUM
dti-1295	77	14	3	3	NUM
dti-1295	77	15	4	4	NUM
dti-1295	77	16	5	5	NUM
dti-1295	77	17	6	6	NUM
dti-1295	77	18	7	7	NUM
dti-1295	77	19	0	0	NUM
dti-1295	77	20	5	5	NUM
dti-1295	77	21	10	10	NUM
dti-1295	77	22	15	15	NUM
dti-1295	77	23	20	20	NUM
dti-1295	77	24	25	25	NUM
dti-1295	77	25	30	30	NUM
dti-1295	77	26	35	35	NUM
dti-1295	77	27	iia	iia	NOUN
dti-1295	77	28	a	a	DET
dti-1295	77	29	ct	ct	NOUN
dti-1295	77	30	iv	iv	NOUN
dti-1295	77	31	ity	ity	PROPN
dti-1295	78	1	[	[	X
dti-1295	78	2	i	i	PRON
dti-1295	78	3	u	u	NOUN
dti-1295	78	4	/m	/m	PUNCT
dti-1295	78	5	l	l	X
dti-1295	78	6	]	]	X
dti-1295	78	7	crt	crt	PROPN
dti-1295	78	8	[	[	X
dti-1295	78	9	min	min	X
dti-1295	78	10	]	]	X
dti-1295	78	11	the	the	DET
dti-1295	78	12	thrombin	thrombin	NOUN
dti-1295	78	13	generation	generation	NOUN
dti-1295	78	14	in	in	ADP
dti-1295	78	15	the	the	DET
dti-1295	78	16	inca	inca	NOUN
dti-1295	78	17	at	at	ADP
dti-1295	78	18	crt	crt	PROPN
dti-1295	78	19	<	<	X
dti-1295	78	20	20	20	NUM
dti-1295	78	21	min	min	NOUN
dti-1295	78	22	does	do	AUX
dti-1295	78	23	not	not	PART
dti-1295	78	24	exceed	exceed	VERB
dti-1295	78	25	0.5	0.5	NUM
dti-1295	78	26	iu	iu	ADP
dti-1295	78	27	thrombin	thrombin	NOUN
dti-1295	78	28	/	/	SYM
dti-1295	78	29	ml	ml	NOUN
dti-1295	78	30	sample	sample	NOUN
dti-1295	78	31	(	(	PUNCT
dti-1295	78	32	fig	fig	NOUN
dti-1295	78	33	.	.	PUNCT
dti-1295	79	1	1b	1b	NUM
dti-1295	79	2	,	,	PUNCT
dti-1295	79	3	c	c	NOUN
dti-1295	79	4	)	)	PUNCT
dti-1295	79	5	.	.	PUNCT
dti-1295	80	1	the	the	DET
dti-1295	80	2	inca	inca	PROPN
dti-1295	80	3	curves	curve	NOUN
dti-1295	80	4	are	be	AUX
dti-1295	80	5	evaluated	evaluate	VERB
dti-1295	80	6	in	in	ADP
dti-1295	80	7	their	their	PRON
dti-1295	80	8	important	important	ADJ
dti-1295	80	9	pre	pre	ADJ
dti-1295	80	10	-	-	ADJ
dti-1295	80	11	maximum	maximum	ADJ
dti-1295	80	12	phase	phase	NOUN
dti-1295	80	13	.	.	PUNCT
dti-1295	81	1	the	the	DET
dti-1295	81	2	ic50	ic50	PROPN
dti-1295	81	3	of	of	ADP
dti-1295	81	4	aprotinin	aprotinin	NOUN
dti-1295	81	5	on	on	ADP
dti-1295	81	6	the	the	DET
dti-1295	81	7	inca	inca	NOUN
dti-1295	81	8	is	be	AUX
dti-1295	81	9	about	about	ADV
dti-1295	81	10	25	25	NUM
dti-1295	81	11	kiu	kiu	NOUN
dti-1295	81	12	/	/	SYM
dti-1295	81	13	ml	ml	PROPN
dti-1295	81	14	(	(	PUNCT
dti-1295	81	15	fig	fig	NOUN
dti-1295	81	16	.	.	PUNCT
dti-1295	82	1	2	2	NUM
dti-1295	82	2	)	)	PUNCT
dti-1295	82	3	.	.	PUNCT
dti-1295	83	1	this	this	PRON
dti-1295	83	2	reflects	reflect	VERB
dti-1295	83	3	the	the	DET
dti-1295	83	4	extreme	extreme	ADJ
dti-1295	83	5	sensitivity	sensitivity	NOUN
dti-1295	83	6	of	of	ADP
dti-1295	83	7	the	the	DET
dti-1295	83	8	inca	inca	NOUN
dti-1295	83	9	:	:	PUNCT
dti-1295	83	10	in	in	ADP
dti-1295	83	11	the	the	DET
dti-1295	83	12	usual	usual	ADJ
dti-1295	83	13	aptt	aptt	NOUN
dti-1295	83	14	the	the	DET
dti-1295	83	15	aprotinin	aprotinin	PROPN
dti-1295	83	16	concentration	concentration	NOUN
dti-1295	83	17	that	that	PRON
dti-1295	83	18	prolongs	prolong	VERB
dti-1295	83	19	the	the	DET
dti-1295	83	20	normal	normal	ADJ
dti-1295	83	21	aptt	aptt	ADJ
dti-1295	83	22	1.5	1.5	NUM
dti-1295	83	23	fold	fold	NOUN
dti-1295	83	24	is	be	AUX
dti-1295	83	25	300	300	NUM
dti-1295	83	26	kiu	kiu	NOUN
dti-1295	83	27	/	/	SYM
dti-1295	83	28	ml	ml	NOUN
dti-1295	83	29	.	.	PUNCT
dti-1295	83	30	arginine	arginine	PROPN
dti-1295	83	31	dose	dose	PROPN
dti-1295	83	32	-	-	PUNCT
dti-1295	83	33	dependently	dependently	ADV
dti-1295	83	34	inhibits	inhibit	VERB
dti-1295	83	35	inca	inca	PROPN
dti-1295	83	36	(	(	PUNCT
dti-1295	83	37	fig	fig	NOUN
dti-1295	83	38	.	.	PUNCT
dti-1295	84	1	3	3	NUM
dti-1295	84	2	)	)	PUNCT
dti-1295	84	3	.	.	PUNCT
dti-1295	85	1	the	the	DET
dti-1295	85	2	ic50	ic50	PROPN
dti-1295	85	3	values	value	NOUN
dti-1295	85	4	were	be	AUX
dti-1295	85	5	about	about	ADV
dti-1295	85	6	12	12	NUM
dti-1295	85	7	mm	mm	NOUN
dti-1295	85	8	for	for	ADP
dti-1295	85	9	commercially	commercially	ADV
dti-1295	85	10	available	available	ADJ
dti-1295	85	11	arginine	arginine	NOUN
dti-1295	85	12	for	for	ADP
dti-1295	85	13	i.v	i.v	PROPN
dti-1295	85	14	.	.	PUNCT
dti-1295	85	15	infusion	infusion	NOUN
dti-1295	85	16	and	and	CCONJ
dti-1295	85	17	about	about	ADV
dti-1295	85	18	8	8	NUM
dti-1295	85	19	mm	mm	NOUN
dti-1295	85	20	for	for	ADP
dti-1295	85	21	alkaline	alkaline	NOUN
dti-1295	85	22	arginine	arginine	NOUN
dti-1295	85	23	(	(	PUNCT
dti-1295	85	24	at	at	ADP
dti-1295	85	25	ph	ph	NOUN
dti-1295	85	26	8.7	8.7	NUM
dti-1295	85	27	)	)	PUNCT
dti-1295	85	28	.	.	PUNCT
dti-1295	86	1	normal	normal	ADJ
dti-1295	86	2	plasma	plasma	NOUN
dti-1295	86	3	supplemented	supplement	VERB
dti-1295	86	4	with	with	ADP
dti-1295	86	5	1.2	1.2	NUM
dti-1295	86	6	g	g	NOUN
dti-1295	86	7	/	/	SYM
dti-1295	86	8	l	l	NOUN
dti-1295	86	9	purifi	purifi	PROPN
dti-1295	86	10	ed	ed	PROPN
dti-1295	86	11	fi	fi	NOUN
dti-1295	86	12	brinogen	brinogen	NOUN
dti-1295	86	13	containing	contain	VERB
dti-1295	86	14	1	1	NUM
dti-1295	86	15	%	%	NOUN
dti-1295	86	16	soluble	soluble	ADJ
dti-1295	86	17	fi	fi	NOUN
dti-1295	86	18	brin	brin	PROPN
dti-1295	86	19	resulted	result	VERB
dti-1295	86	20	in	in	ADP
dti-1295	86	21	a	a	DET
dti-1295	86	22	50	50	NUM
dti-1295	86	23	%	%	NOUN
dti-1295	86	24	decrease	decrease	NOUN
dti-1295	86	25	of	of	ADP
dti-1295	86	26	iia	iia	NOUN
dti-1295	86	27	–	–	PUNCT
dti-1295	86	28	generation	generation	NOUN
dti-1295	86	29	:	:	PUNCT
dti-1295	86	30	plasmatic	plasmatic	ADJ
dti-1295	86	31	fi	fi	NOUN
dti-1295	86	32	brin	brin	PROPN
dti-1295	86	33	entraps	entrap	VERB
dti-1295	86	34	generated	generate	VERB
dti-1295	86	35	thrombin	thrombin	NOUN
dti-1295	86	36	,	,	PUNCT
dti-1295	86	37	that	that	PRON
dti-1295	86	38	is	be	AUX
dti-1295	86	39	why	why	SCONJ
dti-1295	86	40	fi	fi	NOUN
dti-1295	86	41	brin	brin	PROPN
dti-1295	86	42	can	can	AUX
dti-1295	86	43	be	be	AUX
dti-1295	86	44	considered	consider	VERB
dti-1295	86	45	as	as	ADP
dti-1295	86	46	antithrombin	antithrombin	ADJ
dti-1295	86	47	i	i	PROPN
dti-1295	86	48	(	(	PUNCT
dti-1295	86	49	8)	8)	NUM
dti-1295	86	50	.	.	PUNCT
dti-1295	86	51	figure	figure	NOUN
dti-1295	86	52	1c	1c	NOUN
dti-1295	86	53	.	.	PUNCT
dti-1295	87	1	reaction	reaction	NOUN
dti-1295	87	2	kinetic	kinetic	NOUN
dti-1295	87	3	of	of	ADP
dti-1295	87	4	unfractionated	unfractionate	VERB
dti-1295	87	5	heparin	heparin	NOUN
dti-1295	87	6	.	.	PUNCT
dti-1295	88	1	20	20	NUM
dti-1295	88	2	µl	µl	ADP
dti-1295	88	3	unfrozen	unfrozen	NOUN
dti-1295	88	4	pooled	pool	VERB
dti-1295	88	5	normal	normal	ADJ
dti-1295	88	6	plasma	plasma	NOUN
dti-1295	88	7	,	,	PUNCT
dti-1295	88	8	supplemented	supplement	VERB
dti-1295	88	9	with	with	ADP
dti-1295	88	10	0	0	NUM
dti-1295	88	11	iu	iu	NOUN
dti-1295	88	12	/	/	SYM
dti-1295	88	13	ml	ml	NOUN
dti-1295	88	14	(	(	PUNCT
dti-1295	88	15	o	o	NOUN
dti-1295	88	16	)	)	PUNCT
dti-1295	88	17	,	,	PUNCT
dti-1295	88	18	0.063	0.063	NUM
dti-1295	88	19	iu	iu	NOUN
dti-1295	88	20	/	/	SYM
dti-1295	88	21	ml	ml	PROPN
dti-1295	88	22	(	(	PUNCT
dti-1295	88	23	■	■	NOUN
dti-1295	88	24	)	)	PUNCT
dti-1295	88	25	,	,	PUNCT
dti-1295	88	26	0.13	0.13	NUM
dti-1295	88	27	iu	iu	NOUN
dti-1295	88	28	/	/	SYM
dti-1295	88	29	ml	ml	PROPN
dti-1295	88	30	(	(	PUNCT
dti-1295	88	31	♦	♦	PROPN
dti-1295	88	32	)	)	PUNCT
dti-1295	88	33	,	,	PUNCT
dti-1295	88	34	0.25	0.25	NUM
dti-1295	88	35	iu	iu	NOUN
dti-1295	88	36	/	/	SYM
dti-1295	88	37	ml	ml	NOUN
dti-1295	88	38	(	(	PUNCT
dti-1295	88	39	▲	▲	NOUN
dti-1295	88	40	)	)	PUNCT
dti-1295	88	41	,	,	PUNCT
dti-1295	88	42	or	or	CCONJ
dti-1295	88	43	0.5	0.5	NUM
dti-1295	88	44	iu	iu	NOUN
dti-1295	88	45	/	/	SYM
dti-1295	88	46	ml	ml	NOUN
dti-1295	88	47	(	(	PUNCT
dti-1295	88	48	●	●	NOUN
dti-1295	88	49	)	)	PUNCT
dti-1295	88	50	heparin	heparin	NOUN
dti-1295	88	51	was	be	AUX
dti-1295	88	52	incubated	incubate	VERB
dti-1295	88	53	with	with	ADP
dti-1295	88	54	2	2	NUM
dti-1295	88	55	µl	µl	ADP
dti-1295	88	56	sio2	sio2	PROPN
dti-1295	88	57	/	/	SYM
dti-1295	88	58	cacl2	cacl2	NOUN
dti-1295	88	59	reagent	reagent	NOUN
dti-1295	88	60	.	.	PUNCT
dti-1295	89	1	after	after	SCONJ
dti-1295	89	2	0–30	0–30	PROPN
dti-1295	89	3	min	min	PROPN
dti-1295	89	4	crt	crt	PROPN
dti-1295	89	5	at	at	ADP
dti-1295	89	6	37	37	NUM
dti-1295	89	7	°	°	ADP
dti-1295	89	8	c	c	NOUN
dti-1295	89	9	in	in	ADP
dti-1295	89	10	the	the	DET
dti-1295	89	11	water	water	NOUN
dti-1295	89	12	-	-	PUNCT
dti-1295	89	13	bath	bath	NOUN
dti-1295	89	14	50	50	NUM
dti-1295	89	15	µl	µl	ADP
dti-1295	89	16	2.5	2.5	NUM
dti-1295	89	17	m	m	NOUN
dti-1295	89	18	arginine	arginine	NOUN
dti-1295	89	19	,	,	PUNCT
dti-1295	89	20	ph	ph	NOUN
dti-1295	89	21	8.6	8.6	NUM
dti-1295	89	22	,	,	PUNCT
dti-1295	89	23	was	be	AUX
dti-1295	89	24	added	add	VERB
dti-1295	89	25	.	.	PUNCT
dti-1295	90	1	after	after	SCONJ
dti-1295	90	2	20	20	NUM
dti-1295	90	3	min	min	NOUN
dti-1295	90	4	(	(	PUNCT
dti-1295	90	5	rt	rt	PROPN
dti-1295	90	6	)	)	PUNCT
dti-1295	90	7	20	20	NUM
dti-1295	90	8	µl	µl	ADP
dti-1295	90	9	0.77	0.77	NUM
dti-1295	90	10	mm	mm	NOUN
dti-1295	90	11	chromogenic	chromogenic	ADJ
dti-1295	90	12	thrombin	thrombin	NOUN
dti-1295	90	13	substrate	substrate	NOUN
dti-1295	90	14	in	in	ADP
dti-1295	90	15	2	2	NUM
dti-1295	90	16	m	m	NOUN
dti-1295	90	17	arginine	arginine	NOUN
dti-1295	90	18	was	be	AUX
dti-1295	90	19	added	add	VERB
dti-1295	90	20	and	and	CCONJ
dti-1295	90	21	the	the	DET
dti-1295	90	22	linear	linear	ADJ
dti-1295	90	23	∆a	∆a	PROPN
dti-1295	90	24	/	/	SYM
dti-1295	90	25	t	t	PROPN
dti-1295	90	26	(	(	PUNCT
dti-1295	90	27	rt	rt	PROPN
dti-1295	90	28	)	)	PUNCT
dti-1295	90	29	was	be	AUX
dti-1295	90	30	determined	determine	VERB
dti-1295	90	31	.	.	PUNCT
dti-1295	91	1	0	0	NUM
dti-1295	91	2	0.5	0.5	NUM
dti-1295	91	3	1	1	NUM
dti-1295	91	4	1.5	1.5	NUM
dti-1295	91	5	2	2	NUM
dti-1295	91	6	2.5	2.5	NUM
dti-1295	91	7	3	3	NUM
dti-1295	91	8	0	0	NUM
dti-1295	91	9	5	5	NUM
dti-1295	91	10	10	10	NUM
dti-1295	91	11	15	15	NUM
dti-1295	91	12	20	20	NUM
dti-1295	91	13	25	25	NUM
dti-1295	91	14	30	30	NUM
dti-1295	91	15	35	35	NUM
dti-1295	91	16	iia	iia	NOUN
dti-1295	91	17	a	a	DET
dti-1295	91	18	ct	ct	NOUN
dti-1295	91	19	iv	iv	NOUN
dti-1295	91	20	ity	ity	PROPN
dti-1295	92	1	[	[	X
dti-1295	92	2	i	i	PRON
dti-1295	92	3	u	u	NOUN
dti-1295	92	4	/m	/m	PUNCT
dti-1295	92	5	l	l	X
dti-1295	92	6	]	]	X
dti-1295	92	7	crt	crt	PROPN
dti-1295	92	8	[	[	X
dti-1295	92	9	min	min	X
dti-1295	92	10	]	]	X
dti-1295	92	11	figure	figure	NOUN
dti-1295	92	12	2	2	NUM
dti-1295	92	13	.	.	PUNCT
dti-1295	92	14	inhibition	inhibition	NOUN
dti-1295	92	15	of	of	ADP
dti-1295	92	16	intrinsic	intrinsic	ADJ
dti-1295	92	17	thrombin	thrombin	NOUN
dti-1295	92	18	generation	generation	NOUN
dti-1295	92	19	by	by	ADP
dti-1295	92	20	aprotinin	aprotinin	PROPN
dti-1295	92	21	.	.	PUNCT
dti-1295	93	1	figure	figure	NOUN
dti-1295	93	2	2a	2a	NUM
dti-1295	93	3	.	.	PUNCT
dti-1295	94	1	20	20	NUM
dti-1295	94	2	µl	µl	ADP
dti-1295	94	3	unfrozen	unfrozen	NOUN
dti-1295	94	4	pooled	pool	VERB
dti-1295	94	5	normal	normal	ADJ
dti-1295	94	6	plasma	plasma	NOUN
dti-1295	94	7	,	,	PUNCT
dti-1295	94	8	supplemented	supplement	VERB
dti-1295	94	9	with	with	ADP
dti-1295	94	10	0	0	NUM
dti-1295	94	11	kiu	kiu	X
dti-1295	94	12	/	/	SYM
dti-1295	94	13	ml	ml	PROPN
dti-1295	94	14	(	(	PUNCT
dti-1295	94	15	o	o	NOUN
dti-1295	94	16	)	)	PUNCT
dti-1295	94	17	,	,	PUNCT
dti-1295	94	18	25	25	NUM
dti-1295	94	19	kiu	kiu	NOUN
dti-1295	94	20	/	/	SYM
dti-1295	94	21	ml	ml	PROPN
dti-1295	94	22	(	(	PUNCT
dti-1295	94	23	∆	∆	PROPN
dti-1295	94	24	)	)	PUNCT
dti-1295	94	25	,	,	PUNCT
dti-1295	94	26	50	50	NUM
dti-1295	94	27	kiu	kiu	NOUN
dti-1295	94	28	/	/	SYM
dti-1295	94	29	ml	ml	PROPN
dti-1295	94	30	(	(	PUNCT
dti-1295	94	31	□	□	NUM
dti-1295	94	32	)	)	PUNCT
dti-1295	94	33	,	,	PUNCT
dti-1295	94	34	100	100	NUM
dti-1295	94	35	kiu	kiu	NOUN
dti-1295	94	36	/	/	SYM
dti-1295	94	37	ml	ml	PROPN
dti-1295	94	38	(	(	PUNCT
dti-1295	94	39	■	■	NOUN
dti-1295	94	40	)	)	PUNCT
dti-1295	94	41	,	,	PUNCT
dti-1295	94	42	200	200	NUM
dti-1295	94	43	kiu	kiu	NOUN
dti-1295	94	44	/	/	SYM
dti-1295	94	45	ml	ml	PROPN
dti-1295	94	46	(	(	PUNCT
dti-1295	94	47	▲	▲	NOUN
dti-1295	94	48	)	)	PUNCT
dti-1295	94	49	,	,	PUNCT
dti-1295	94	50	or	or	CCONJ
dti-1295	94	51	400	400	NUM
dti-1295	94	52	kiu	kiu	NOUN
dti-1295	94	53	/	/	SYM
dti-1295	94	54	ml	ml	PROPN
dti-1295	94	55	(	(	PUNCT
dti-1295	94	56	●	●	NOUN
dti-1295	94	57	)	)	PUNCT
dti-1295	94	58	aprotinin	aprotinin	NOUN
dti-1295	94	59	,	,	PUNCT
dti-1295	94	60	were	be	AUX
dti-1295	94	61	tested	test	VERB
dti-1295	94	62	in	in	ADP
dti-1295	94	63	the	the	DET
dti-1295	94	64	inca	inca	NOUN
dti-1295	94	65	(	(	PUNCT
dti-1295	94	66	u	u	NOUN
dti-1295	94	67	-	-	NOUN
dti-1295	94	68	wells	well	NOUN
dti-1295	94	69	)	)	PUNCT
dti-1295	94	70	.	.	PUNCT
dti-1295	95	1	drug	drug	NOUN
dti-1295	95	2	target	target	NOUN
dti-1295	95	3	insights	insight	NOUN
dti-1295	95	4	2006:18	2006:18	NUM
dti-1295	95	5	thomas	thomas	PROPN
dti-1295	95	6	w.	w.	PROPN
dti-1295	95	7	stief	stief	PROPN
dti-1295	95	8	this	this	DET
dti-1295	95	9	decrease	decrease	NOUN
dti-1295	95	10	in	in	ADP
dti-1295	95	11	iia	iia	NOUN
dti-1295	95	12	-	-	PUNCT
dti-1295	95	13	generation	generation	NOUN
dti-1295	95	14	was	be	AUX
dti-1295	95	15	independent	independent	ADJ
dti-1295	95	16	of	of	ADP
dti-1295	95	17	added	add	VERB
dti-1295	95	18	anticoagulant	anticoagulant	NOUN
dti-1295	95	19	.	.	PUNCT
dti-1295	96	1	discussion	discussion	NOUN
dti-1295	96	2	the	the	DET
dti-1295	96	3	aptt	aptt	NOUN
dti-1295	96	4	does	do	AUX
dti-1295	96	5	not	not	PART
dti-1295	96	6	refl	refl	VERB
dti-1295	96	7	ect	ect	ADP
dti-1295	96	8	the	the	DET
dti-1295	96	9	effi	effi	PROPN
dti-1295	96	10	ciency	ciency	NOUN
dti-1295	96	11	of	of	ADP
dti-1295	96	12	some	some	DET
dti-1295	96	13	important	important	ADJ
dti-1295	96	14	clinically	clinically	ADV
dti-1295	96	15	used	use	VERB
dti-1295	96	16	anticoagulants	anticoagulant	NOUN
dti-1295	96	17	,	,	PUNCT
dti-1295	96	18	such	such	ADJ
dti-1295	96	19	as	as	ADP
dti-1295	96	20	e.g.	e.g.	ADV
dti-1295	96	21	the	the	DET
dti-1295	96	22	lmwh	lmwh	NOUN
dti-1295	96	23	[	[	X
dti-1295	96	24	fareed	fareed	PROPN
dti-1295	96	25	et	et	PROPN
dti-1295	96	26	al	al	PROPN
dti-1295	96	27	.	.	PROPN
dti-1295	96	28	2004	2004	NUM
dti-1295	96	29	]	]	PUNCT
dti-1295	96	30	.	.	PUNCT
dti-1295	97	1	the	the	DET
dti-1295	97	2	sio2	sio2	PROPN
dti-1295	97	3	amount	amount	NOUN
dti-1295	97	4	used	use	VERB
dti-1295	97	5	to	to	PART
dti-1295	97	6	trigger	trigger	VERB
dti-1295	97	7	the	the	DET
dti-1295	97	8	inca	inca	NOUN
dti-1295	97	9	is	be	AUX
dti-1295	97	10	about	about	ADP
dti-1295	97	11	100fold	100fold	PROPN
dti-1295	97	12	below	below	ADP
dti-1295	97	13	the	the	DET
dti-1295	97	14	contact	contact	NOUN
dti-1295	97	15	activator	activator	NOUN
dti-1295	97	16	amount	amount	NOUN
dti-1295	97	17	used	use	VERB
dti-1295	97	18	for	for	ADP
dti-1295	97	19	the	the	DET
dti-1295	97	20	aptt	aptt	NOUN
dti-1295	97	21	,	,	PUNCT
dti-1295	97	22	and	and	CCONJ
dti-1295	97	23	in	in	ADP
dti-1295	97	24	contrast	contrast	NOUN
dti-1295	97	25	to	to	ADP
dti-1295	97	26	the	the	DET
dti-1295	97	27	usual	usual	ADJ
dti-1295	97	28	global	global	ADJ
dti-1295	97	29	coagulation	coagulation	NOUN
dti-1295	97	30	test	test	NOUN
dti-1295	97	31	aptt	aptt	ADV
dti-1295	97	32	the	the	DET
dti-1295	97	33	plasma	plasma	NOUN
dti-1295	97	34	matrix	matrix	NOUN
dti-1295	97	35	in	in	ADP
dti-1295	97	36	the	the	DET
dti-1295	97	37	inca	inca	NOUN
dti-1295	97	38	is	be	AUX
dti-1295	97	39	not	not	PART
dti-1295	97	40	signifi	signifi	NOUN
dti-1295	97	41	cantly	cantly	ADV
dti-1295	97	42	changed	change	VERB
dti-1295	97	43	(	(	PUNCT
dti-1295	97	44	only	only	ADV
dti-1295	97	45	1	1	NUM
dti-1295	97	46	part	part	NOUN
dti-1295	97	47	of	of	ADP
dti-1295	97	48	reagent	reagent	NOUN
dti-1295	97	49	to	to	ADP
dti-1295	97	50	10	10	NUM
dti-1295	97	51	parts	part	NOUN
dti-1295	97	52	of	of	ADP
dti-1295	97	53	citrate	citrate	NOUN
dti-1295	97	54	plasma	plasma	NOUN
dti-1295	97	55	)	)	PUNCT
dti-1295	97	56	.	.	PUNCT
dti-1295	98	1	the	the	DET
dti-1295	98	2	inca	inca	NOUN
dti-1295	98	3	monitors	monitor	VERB
dti-1295	98	4	the	the	DET
dti-1295	98	5	anticoagulant	anticoagulant	ADJ
dti-1295	98	6	potency	potency	NOUN
dti-1295	98	7	of	of	ADP
dti-1295	98	8	anti	anti	ADJ
dti-1295	98	9	-	-	NOUN
dti-1295	98	10	factor	factor	ADJ
dti-1295	98	11	xa	xa	NOUN
dti-1295	98	12	or	or	CCONJ
dti-1295	98	13	anti	anti	ADJ
dti-1295	98	14	-	-	ADJ
dti-1295	98	15	thrombin	thrombin	ADJ
dti-1295	98	16	drugs	drug	NOUN
dti-1295	99	1	[	[	X
dti-1295	99	2	tobu	tobu	X
dti-1295	99	3	et	et	PROPN
dti-1295	99	4	al	al	PROPN
dti-1295	99	5	.	.	PROPN
dti-1295	99	6	2004	2004	NUM
dti-1295	99	7	]	]	X
dti-1295	99	8	:	:	PUNCT
dti-1295	99	9	lmw	lmw	ADJ
dti-1295	99	10	-	-	PUNCT
dti-1295	99	11	heparins	heparin	NOUN
dti-1295	99	12	are	be	AUX
dti-1295	99	13	powerful	powerful	ADJ
dti-1295	99	14	inhibitors	inhibitor	NOUN
dti-1295	99	15	of	of	ADP
dti-1295	99	16	iia	iia	NOUN
dti-1295	99	17	generation	generation	NOUN
dti-1295	99	18	,	,	PUNCT
dti-1295	99	19	especially	especially	ADV
dti-1295	99	20	via	via	ADP
dti-1295	99	21	inhibition	inhibition	NOUN
dti-1295	99	22	of	of	ADP
dti-1295	99	23	factor	factor	NOUN
dti-1295	99	24	xa	xa	PROPN
dti-1295	99	25	.	.	PUNCT
dti-1295	100	1	in	in	ADP
dti-1295	100	2	an	an	DET
dti-1295	100	3	inca	inca	PROPN
dti-1295	100	4	test	test	NOUN
dti-1295	100	5	version	version	NOUN
dti-1295	100	6	with	with	ADP
dti-1295	100	7	an	an	DET
dti-1295	100	8	assay	assay	NOUN
dti-1295	100	9	incubation	incubation	NOUN
dti-1295	100	10	at	at	ADP
dti-1295	100	11	37	37	NUM
dti-1295	100	12	°	°	NOUN
dti-1295	100	13	c	c	NOUN
dti-1295	100	14	prolonged	prolong	VERB
dti-1295	100	15	to	to	ADP
dti-1295	100	16	12	12	NUM
dti-1295	100	17	min	min	NOUN
dti-1295	100	18	(	(	PUNCT
dti-1295	100	19	inca-12	inca-12	PROPN
dti-1295	100	20	)	)	PUNCT
dti-1295	100	21	patient	patient	NOUN
dti-1295	100	22	aptt	aptt	ADJ
dti-1295	100	23	values	value	NOUN
dti-1295	100	24	of	of	ADP
dti-1295	100	25	about	about	ADV
dti-1295	100	26	40	40	NUM
dti-1295	100	27	s	s	NOUN
dti-1295	100	28	correspond	correspond	NOUN
dti-1295	100	29	to	to	ADP
dti-1295	100	30	about	about	ADV
dti-1295	100	31	1	1	NUM
dti-1295	100	32	iu	iu	NOUN
dti-1295	100	33	/	/	SYM
dti-1295	100	34	ml	ml	NOUN
dti-1295	100	35	iia	iia	NOUN
dti-1295	100	36	generation	generation	NOUN
dti-1295	100	37	,	,	PUNCT
dti-1295	100	38	aptt	aptt	ADJ
dti-1295	100	39	values	value	NOUN
dti-1295	100	40	of	of	ADP
dti-1295	100	41	50–60	50–60	NUM
dti-1295	100	42	s	s	VERB
dti-1295	100	43	to	to	ADP
dti-1295	100	44	about	about	ADV
dti-1295	100	45	0.2	0.2	NUM
dti-1295	100	46	iu	iu	NOUN
dti-1295	100	47	/	/	SYM
dti-1295	100	48	ml	ml	AUX
dti-1295	100	49	iia	iia	VERB
dti-1295	100	50	(	(	PUNCT
dti-1295	100	51	<	<	X
dti-1295	100	52	36	36	NUM
dti-1295	100	53	s	s	NOUN
dti-1295	100	54	=	=	SYM
dti-1295	100	55	100	100	NUM
dti-1295	100	56	%	%	NOUN
dti-1295	100	57	of	of	ADP
dti-1295	100	58	norm	norm	NOUN
dti-1295	100	59	aptt	aptt	ADV
dti-1295	100	60	;	;	PUNCT
dti-1295	100	61	4.3	4.3	NUM
dti-1295	100	62	±	±	NOUN
dti-1295	100	63	1.4	1.4	NUM
dti-1295	100	64	iu	iu	NOUN
dti-1295	100	65	/	/	SYM
dti-1295	100	66	ml	ml	VERB
dti-1295	100	67	iia	iia	VERB
dti-1295	100	68	=	=	SYM
dti-1295	100	69	100	100	NUM
dti-1295	100	70	%	%	NOUN
dti-1295	100	71	of	of	ADP
dti-1295	100	72	norm	norm	NOUN
dti-1295	100	73	iia	iia	NOUN
dti-1295	100	74	generation	generation	NOUN
dti-1295	100	75	)	)	PUNCT
dti-1295	101	1	[	[	X
dti-1295	101	2	stief	stief	X
dti-1295	101	3	et	et	PROPN
dti-1295	101	4	al	al	PROPN
dti-1295	101	5	.	.	PROPN
dti-1295	101	6	2006	2006	NUM
dti-1295	101	7	]	]	PUNCT
dti-1295	101	8	.	.	PUNCT
dti-1295	102	1	the	the	DET
dti-1295	102	2	usual	usual	ADJ
dti-1295	102	3	plasmatic	plasmatic	NOUN
dti-1295	102	4	unfractionated	unfractionate	VERB
dti-1295	102	5	heparin	heparin	ADJ
dti-1295	102	6	concentrations	concentration	NOUN
dti-1295	102	7	in	in	ADP
dti-1295	102	8	therapeutic	therapeutic	ADJ
dti-1295	102	9	anticoagulation	anticoagulation	NOUN
dti-1295	102	10	are	be	AUX
dti-1295	102	11	about	about	ADV
dti-1295	102	12	10fold	10fold	NUM
dti-1295	102	13	higher	high	ADJ
dti-1295	102	14	than	than	ADP
dti-1295	102	15	the	the	DET
dti-1295	102	16	ic50	ic50	PROPN
dti-1295	102	17	values	value	NOUN
dti-1295	102	18	observed	observe	VERB
dti-1295	102	19	here	here	ADV
dti-1295	102	20	in	in	ADP
dti-1295	102	21	the	the	DET
dti-1295	102	22	inca	inca	NOUN
dti-1295	102	23	.	.	PUNCT
dti-1295	103	1	the	the	DET
dti-1295	103	2	superior	superior	ADJ
dti-1295	103	3	anticoagulant	anticoagulant	ADJ
dti-1295	103	4	capacity	capacity	NOUN
dti-1295	103	5	of	of	ADP
dti-1295	103	6	lmwh	lmwh	NOUN
dti-1295	103	7	compared	compare	VERB
dti-1295	103	8	to	to	ADP
dti-1295	103	9	unfractionated	unfractionate	VERB
dti-1295	103	10	heparin	heparin	NOUN
dti-1295	103	11	might	might	AUX
dti-1295	103	12	be	be	AUX
dti-1295	103	13	due	due	ADJ
dti-1295	103	14	to	to	ADP
dti-1295	103	15	some	some	DET
dti-1295	103	16	contact	contact	NOUN
dti-1295	103	17	activating	activate	VERB
dti-1295	103	18	0	0	NUM
dti-1295	103	19	0.5	0.5	NUM
dti-1295	103	20	1	1	NUM
dti-1295	103	21	1.5	1.5	NUM
dti-1295	103	22	2	2	NUM
dti-1295	103	23	2.5	2.5	NUM
dti-1295	103	24	3	3	NUM
dti-1295	103	25	0	0	NUM
dti-1295	103	26	50	50	NUM
dti-1295	103	27	100	100	NUM
dti-1295	103	28	150	150	NUM
dti-1295	103	29	200	200	NUM
dti-1295	103	30	250	250	NUM
dti-1295	103	31	300	300	NUM
dti-1295	103	32	350	350	NUM
dti-1295	103	33	400	400	NUM
dti-1295	103	34	450	450	NUM
dti-1295	103	35	iia	iia	NOUN
dti-1295	103	36	a	a	DET
dti-1295	103	37	ct	ct	NOUN
dti-1295	103	38	iv	iv	NOUN
dti-1295	103	39	ity	ity	PROPN
dti-1295	104	1	[	[	X
dti-1295	104	2	i	i	PRON
dti-1295	104	3	u	u	NOUN
dti-1295	104	4	/m	/m	PUNCT
dti-1295	104	5	l	l	NOUN
dti-1295	104	6	]	]	X
dti-1295	104	7	aprotinin	aprotinin	NOUN
dti-1295	104	8	activity	activity	NOUN
dti-1295	104	9	[	[	X
dti-1295	104	10	klu	klu	PROPN
dti-1295	104	11	/	/	SYM
dti-1295	104	12	ml	ml	NOUN
dti-1295	104	13	]	]	PUNCT
dti-1295	104	14	figure	figure	NOUN
dti-1295	104	15	2b	2b	NOUN
dti-1295	104	16	.	.	PUNCT
dti-1295	105	1	crt	crt	PROPN
dti-1295	105	2	=	=	SYM
dti-1295	105	3	10	10	NUM
dti-1295	105	4	min	min	NOUN
dti-1295	105	5	(	(	PUNCT
dti-1295	105	6	●	●	NOUN
dti-1295	105	7	)	)	PUNCT
dti-1295	105	8	,	,	PUNCT
dti-1295	105	9	crt	crt	NOUN
dti-1295	105	10	=	=	SYM
dti-1295	105	11	15	15	NUM
dti-1295	105	12	min	min	NOUN
dti-1295	105	13	(	(	PUNCT
dti-1295	105	14	■	■	NOUN
dti-1295	105	15	)	)	PUNCT
dti-1295	105	16	.	.	PUNCT
dti-1295	106	1	0	0	NUM
dti-1295	106	2	0.5	0.5	NUM
dti-1295	106	3	1	1	NUM
dti-1295	106	4	1.5	1.5	NUM
dti-1295	106	5	2	2	NUM
dti-1295	106	6	2.5	2.5	NUM
dti-1295	106	7	3	3	NUM
dti-1295	106	8	3.5	3.5	NUM
dti-1295	106	9	4	4	NUM
dti-1295	106	10	4.5	4.5	NUM
dti-1295	106	11	0	0	NUM
dti-1295	106	12	2	2	NUM
dti-1295	106	13	4	4	NUM
dti-1295	106	14	6	6	NUM
dti-1295	106	15	8	8	NUM
dti-1295	106	16	1	1	NUM
dti-1295	106	17	4	4	NUM
dti-1295	106	18	16	16	NUM
dti-1295	106	19	iia	iia	NOUN
dti-1295	106	20	a	a	DET
dti-1295	106	21	ct	ct	NOUN
dti-1295	106	22	iv	iv	NOUN
dti-1295	106	23	ity	ity	PROPN
dti-1295	107	1	[	[	X
dti-1295	107	2	i	i	PRON
dti-1295	107	3	u	u	NOUN
dti-1295	107	4	/m	/m	PUNCT
dti-1295	107	5	l	l	NOUN
dti-1295	107	6	]	]	X
dti-1295	107	7	0	0	NUM
dti-1295	107	8	112	112	NUM
dti-1295	107	9	crt	crt	ADJ
dti-1295	107	10	[	[	X
dti-1295	107	11	min	min	X
dti-1295	107	12	]	]	X
dti-1295	107	13	figure	figure	NOUN
dti-1295	107	14	3	3	NUM
dti-1295	107	15	.	.	PUNCT
dti-1295	107	16	inhibition	inhibition	NOUN
dti-1295	107	17	of	of	ADP
dti-1295	107	18	intrinsic	intrinsic	ADJ
dti-1295	107	19	thrombin	thrombin	NOUN
dti-1295	107	20	generation	generation	NOUN
dti-1295	107	21	by	by	ADP
dti-1295	107	22	arginine	arginine	NOUN
dti-1295	107	23	.	.	PUNCT
dti-1295	108	1	figure	figure	NOUN
dti-1295	108	2	3a	3a	NUM
dti-1295	108	3	.	.	PUNCT
dti-1295	109	1	unfrozen	unfrozen	PROPN
dti-1295	109	2	pooled	pool	VERB
dti-1295	109	3	normal	normal	ADJ
dti-1295	109	4	plasma	plasma	NOUN
dti-1295	109	5	was	be	AUX
dti-1295	109	6	supplemented	supplement	VERB
dti-1295	109	7	with	with	ADP
dti-1295	109	8	0–40	0–40	PROPN
dti-1295	109	9	mm	mm	NOUN
dti-1295	109	10	arginine	arginine	NOUN
dti-1295	109	11	.	.	PUNCT
dti-1295	110	1	50	50	NUM
dti-1295	110	2	µl	µl	ADP
dti-1295	110	3	samples	sample	NOUN
dti-1295	110	4	in	in	ADP
dti-1295	110	5	f	f	PROPN
dti-1295	110	6	-	-	PUNCT
dti-1295	110	7	wells	well	NOUN
dti-1295	110	8	were	be	AUX
dti-1295	110	9	tested	test	VERB
dti-1295	110	10	in	in	ADP
dti-1295	110	11	the	the	DET
dti-1295	110	12	inca	inca	NOUN
dti-1295	110	13	:	:	PUNCT
dti-1295	111	1	0	0	NUM
dti-1295	111	2	mm	mm	INTJ
dti-1295	111	3	(	(	PUNCT
dti-1295	111	4	o	o	NOUN
dti-1295	111	5	)	)	PUNCT
dti-1295	111	6	,	,	PUNCT
dti-1295	111	7	5	5	NUM
dti-1295	111	8	mm	mm	NOUN
dti-1295	111	9	(	(	PUNCT
dti-1295	111	10	▲	▲	NOUN
dti-1295	111	11	)	)	PUNCT
dti-1295	111	12	,	,	PUNCT
dti-1295	111	13	10	10	NUM
dti-1295	111	14	mm	mm	NOUN
dti-1295	111	15	(	(	PUNCT
dti-1295	111	16	●	●	NOUN
dti-1295	111	17	)	)	PUNCT
dti-1295	111	18	,	,	PUNCT
dti-1295	111	19	20	20	NUM
dti-1295	111	20	mm	mm	INTJ
dti-1295	111	21	(	(	PUNCT
dti-1295	111	22	♦	♦	PROPN
dti-1295	111	23	)	)	PUNCT
dti-1295	111	24	,	,	PUNCT
dti-1295	111	25	or	or	CCONJ
dti-1295	111	26	40	40	NUM
dti-1295	111	27	mm	mm	NOUN
dti-1295	111	28	(	(	PUNCT
dti-1295	111	29	■	■	NOUN
dti-1295	111	30	)	)	PUNCT
dti-1295	111	31	arginine	arginine	NOUN
dti-1295	111	32	.	.	PUNCT
dti-1295	112	1	drug	drug	NOUN
dti-1295	112	2	target	target	NOUN
dti-1295	112	3	insights	insight	NOUN
dti-1295	112	4	2006:1	2006:1	NUM
dti-1295	112	5	9	9	NUM
dti-1295	112	6	inhibition	inhibition	NOUN
dti-1295	112	7	of	of	ADP
dti-1295	112	8	intrinsic	intrinsic	ADJ
dti-1295	112	9	thrombin	thrombin	NOUN
dti-1295	112	10	generation	generation	NOUN
dti-1295	112	11	(	(	PUNCT
dti-1295	112	12	pre	pre	ADJ
dti-1295	112	13	-	-	ADJ
dti-1295	112	14	kallikrein	kallikrein	ADJ
dti-1295	112	15	to	to	PART
dti-1295	112	16	kallikrein	kallikrein	VERB
dti-1295	112	17	folding	folding	NOUN
dti-1295	112	18	)	)	PUNCT
dti-1295	112	19	potential	potential	NOUN
dti-1295	112	20	of	of	ADP
dti-1295	112	21	unfractionated	unfractionate	VERB
dti-1295	112	22	heparin	heparin	NOUN
dti-1295	112	23	,	,	PUNCT
dti-1295	112	24	a	a	DET
dti-1295	112	25	polynegatively	polynegatively	ADV
dti-1295	112	26	charged	charge	VERB
dti-1295	112	27	molecule	molecule	NOUN
dti-1295	112	28	of	of	ADP
dti-1295	112	29	a	a	DET
dti-1295	112	30	molecular	molecular	ADJ
dti-1295	112	31	mass	mass	NOUN
dti-1295	112	32	>	>	X
dti-1295	112	33	15000	15000	NUM
dti-1295	112	34	dalton	dalton	PROPN
dti-1295	113	1	[	[	X
dti-1295	113	2	kongsgaard	kongsgaard	PROPN
dti-1295	113	3	et	et	PROPN
dti-1295	113	4	al	al	PROPN
dti-1295	113	5	.	.	PROPN
dti-1295	113	6	1992	1992	NUM
dti-1295	113	7	]	]	PUNCT
dti-1295	113	8	.	.	PUNCT
dti-1295	114	1	in	in	ADP
dti-1295	114	2	many	many	ADJ
dti-1295	114	3	clinical	clinical	ADJ
dti-1295	114	4	situations	situation	NOUN
dti-1295	114	5	cells	cell	NOUN
dti-1295	114	6	can	can	AUX
dti-1295	114	7	fragment	fragment	VERB
dti-1295	114	8	into	into	ADP
dti-1295	114	9	phospholipidmicroparticles	phospholipidmicroparticle	NOUN
dti-1295	114	10	that	that	PRON
dti-1295	114	11	activate	activate	VERB
dti-1295	114	12	the	the	DET
dti-1295	114	13	intrinsic	intrinsic	ADJ
dti-1295	114	14	pathway	pathway	NOUN
dti-1295	114	15	of	of	ADP
dti-1295	114	16	hemostasis	hemostasis	NOUN
dti-1295	114	17	and	and	CCONJ
dti-1295	114	18	are	be	AUX
dti-1295	114	19	thus	thus	ADV
dti-1295	114	20	of	of	ADP
dti-1295	114	21	great	great	ADJ
dti-1295	114	22	pathophysiologic	pathophysiologic	ADJ
dti-1295	114	23	importance	importance	NOUN
dti-1295	115	1	[	[	X
dti-1295	115	2	soriano	soriano	NOUN
dti-1295	115	3	et	et	PROPN
dti-1295	115	4	al	al	PROPN
dti-1295	115	5	.	.	PROPN
dti-1295	115	6	2005	2005	NUM
dti-1295	115	7	;	;	PUNCT
dti-1295	115	8	boulanger	boulanger	PROPN
dti-1295	115	9	et	et	PROPN
dti-1295	115	10	al	al	PROPN
dti-1295	115	11	.	.	PROPN
dti-1295	115	12	2006	2006	NUM
dti-1295	115	13	]	]	PUNCT
dti-1295	115	14	.	.	PUNCT
dti-1295	116	1	10–20	10–20	NUM
dti-1295	116	2	mm	mm	NOUN
dti-1295	116	3	arginine	arginine	NOUN
dti-1295	116	4	are	be	AUX
dti-1295	116	5	common	common	ADJ
dti-1295	116	6	plasmatic	plasmatic	ADJ
dti-1295	116	7	concentrations	concentration	NOUN
dti-1295	116	8	in	in	ADP
dti-1295	116	9	the	the	DET
dti-1295	116	10	so	so	ADV
dti-1295	116	11	-	-	PUNCT
dti-1295	116	12	called	call	VERB
dti-1295	116	13	arginine	arginine	NOUN
dti-1295	116	14	-	-	PUNCT
dti-1295	116	15	test	test	NOUN
dti-1295	116	16	in	in	ADP
dti-1295	116	17	internal	internal	ADJ
dti-1295	116	18	medicine	medicine	NOUN
dti-1295	117	1	[	[	X
dti-1295	117	2	appleton	appleton	PROPN
dti-1295	117	3	et	et	PROPN
dti-1295	117	4	al	al	PROPN
dti-1295	117	5	.	.	PROPN
dti-1295	117	6	2002	2002	NUM
dti-1295	117	7	;	;	PUNCT
dti-1295	117	8	cylwik	cylwik	PROPN
dti-1295	117	9	et	et	PROPN
dti-1295	117	10	al	al	PROPN
dti-1295	117	11	.	.	PROPN
dti-1295	117	12	2005	2005	NUM
dti-1295	117	13	]	]	PUNCT
dti-1295	117	14	.	.	PUNCT
dti-1295	118	1	therefore	therefore	ADV
dti-1295	118	2	,	,	PUNCT
dti-1295	118	3	arginine	arginine	NOUN
dti-1295	118	4	might	might	AUX
dti-1295	118	5	be	be	AUX
dti-1295	118	6	a	a	DET
dti-1295	118	7	new	new	ADJ
dti-1295	118	8	therapeutic	therapeutic	ADJ
dti-1295	118	9	option	option	NOUN
dti-1295	118	10	in	in	ADP
dti-1295	118	11	patients	patient	NOUN
dti-1295	118	12	with	with	ADP
dti-1295	118	13	severe	severe	ADJ
dti-1295	118	14	disturbances	disturbance	NOUN
dti-1295	118	15	of	of	ADP
dti-1295	118	16	the	the	DET
dti-1295	118	17	coagulation	coagulation	NOUN
dti-1295	118	18	system	system	NOUN
dti-1295	119	1	[	[	X
dti-1295	119	2	lee	lee	PROPN
dti-1295	119	3	and	and	CCONJ
dti-1295	119	4	downey	downey	PROPN
dti-1295	119	5	;	;	PUNCT
dti-1295	119	6	2000	2000	NUM
dti-1295	119	7	]	]	PUNCT
dti-1295	119	8	.	.	PUNCT
dti-1295	120	1	it	it	PRON
dti-1295	120	2	is	be	AUX
dti-1295	120	3	suggested	suggest	VERB
dti-1295	120	4	to	to	PART
dti-1295	120	5	measure	measure	VERB
dti-1295	120	6	the	the	DET
dti-1295	120	7	effi	effi	PROPN
dti-1295	120	8	ciency	ciency	NOUN
dti-1295	120	9	of	of	ADP
dti-1295	120	10	any	any	DET
dti-1295	120	11	anticoagulant	anticoagulant	NOUN
dti-1295	120	12	on	on	ADP
dti-1295	120	13	intrinsic	intrinsic	ADJ
dti-1295	120	14	thrombin	thrombin	NOUN
dti-1295	120	15	generation	generation	NOUN
dti-1295	120	16	for	for	ADP
dti-1295	120	17	each	each	DET
dti-1295	120	18	individual	individual	ADJ
dti-1295	120	19	patient	patient	NOUN
dti-1295	120	20	.	.	PUNCT
dti-1295	121	1	references	reference	NOUN
dti-1295	121	2	appleton	appleton	PROPN
dti-1295	121	3	,	,	PUNCT
dti-1295	121	4	j.	j.	PROPN
dti-1295	121	5	,	,	PUNCT
dti-1295	121	6	arginine	arginine	NOUN
dti-1295	121	7	,	,	PUNCT
dti-1295	121	8	2002	2002	NUM
dti-1295	121	9	.	.	PUNCT
dti-1295	122	1	clinical	clinical	ADJ
dti-1295	122	2	potential	potential	NOUN
dti-1295	122	3	of	of	ADP
dti-1295	122	4	a	a	DET
dti-1295	122	5	semi	semi	ADJ
dti-1295	122	6	-	-	ADJ
dti-1295	122	7	essential	essential	ADJ
dti-1295	122	8	amino	amino	NOUN
dti-1295	122	9	.	.	PUNCT
dti-1295	123	1	alternative	alternative	ADJ
dti-1295	123	2	medicine	medicine	NOUN
dti-1295	123	3	revue	revue	NOUN
dti-1295	123	4	,	,	PUNCT
dti-1295	124	1	7:512–522	7:512–522	NOUN
dti-1295	124	2	.	.	PUNCT
dti-1295	124	3	boulanger	boulanger	PROPN
dti-1295	124	4	,	,	PUNCT
dti-1295	124	5	c.m	c.m	PROPN
dti-1295	124	6	.	.	PROPN
dti-1295	124	7	,	,	PUNCT
dti-1295	124	8	amabile	amabile	PROPN
dti-1295	124	9	,	,	PUNCT
dti-1295	124	10	n.	n.	NOUN
dti-1295	124	11	and	and	CCONJ
dti-1295	124	12	tedgui	tedgui	PROPN
dti-1295	124	13	,	,	PUNCT
dti-1295	124	14	a.	a.	NOUN
dti-1295	124	15	2006	2006	NUM
dti-1295	124	16	.	.	PUNCT
dti-1295	125	1	circulating	circulate	VERB
dti-1295	125	2	microparticles	microparticle	NOUN
dti-1295	125	3	:	:	PUNCT
dti-1295	125	4	a	a	DET
dti-1295	125	5	potential	potential	ADJ
dti-1295	125	6	prognostic	prognostic	ADJ
dti-1295	125	7	marker	marker	NOUN
dti-1295	125	8	for	for	ADP
dti-1295	125	9	atherosclerotic	atherosclerotic	ADJ
dti-1295	125	10	vascular	vascular	ADJ
dti-1295	125	11	disease	disease	NOUN
dti-1295	125	12	.	.	PUNCT
dti-1295	126	1	hypertension	hypertension	NOUN
dti-1295	126	2	,	,	PUNCT
dti-1295	126	3	48:180–186	48:180–186	PROPN
dti-1295	126	4	.	.	PUNCT
dti-1295	127	1	cylwik	cylwik	PROPN
dti-1295	127	2	,	,	PUNCT
dti-1295	127	3	d.	d.	PROPN
dti-1295	127	4	,	,	PUNCT
dti-1295	127	5	mogielnicki	mogielnicki	PROPN
dti-1295	127	6	,	,	PUNCT
dti-1295	127	7	a.	a.	NOUN
dti-1295	127	8	and	and	CCONJ
dti-1295	127	9	buczko	buczko	PROPN
dti-1295	127	10	,	,	PUNCT
dti-1295	127	11	w.	w.	PROPN
dti-1295	127	12	2005	2005	NUM
dti-1295	127	13	.	.	PUNCT
dti-1295	128	1	arginine	arginine	NOUN
dti-1295	128	2	and	and	CCONJ
dti-1295	128	3	cardiovascular	cardiovascular	ADJ
dti-1295	128	4	system	system	NOUN
dti-1295	128	5	.	.	PUNCT
dti-1295	129	1	pharmacological	pharmacological	ADJ
dti-1295	129	2	reports	report	NOUN
dti-1295	129	3	,	,	PUNCT
dti-1295	129	4	57:14–22	57:14–22	NUM
dti-1295	129	5	.	.	PUNCT
dti-1295	130	1	denson	denson	PROPN
dti-1295	130	2	,	,	PUNCT
dti-1295	130	3	k.w.e	k.w.e	PROPN
dti-1295	130	4	.	.	PUNCT
dti-1295	130	5	and	and	CCONJ
dti-1295	130	6	bonnar	bonnar	PROPN
dti-1295	130	7	,	,	PUNCT
dti-1295	130	8	j.	j.	PROPN
dti-1295	130	9	1973	1973	NUM
dti-1295	130	10	.	.	PUNCT
dti-1295	131	1	the	the	DET
dti-1295	131	2	measurement	measurement	NOUN
dti-1295	131	3	of	of	ADP
dti-1295	131	4	heparin	heparin	NOUN
dti-1295	131	5	:	:	PUNCT
dti-1295	131	6	a	a	DET
dti-1295	131	7	method	method	NOUN
dti-1295	131	8	based	base	VERB
dti-1295	131	9	on	on	ADP
dti-1295	131	10	the	the	DET
dti-1295	131	11	potentiation	potentiation	NOUN
dti-1295	131	12	of	of	ADP
dti-1295	131	13	anti	anti	X
dti-1295	131	14	factor	factor	NOUN
dti-1295	131	15	xa	xa	PROPN
dti-1295	131	16	.	.	PUNCT
dti-1295	131	17	thromb	thromb	PROPN
dti-1295	131	18	.	.	PUNCT
dti-1295	132	1	diath	diath	PROPN
dti-1295	132	2	.	.	PUNCT
dti-1295	133	1	haemorrh	haemorrh	PROPN
dti-1295	133	2	.	.	PUNCT
dti-1295	134	1	,	,	PUNCT
dti-1295	134	2	30:471–79	30:471–79	ADV
dti-1295	134	3	.	.	PUNCT
dti-1295	135	1	fareed	fareed	PROPN
dti-1295	135	2	,	,	PUNCT
dti-1295	135	3	j.	j.	PROPN
dti-1295	135	4	,	,	PUNCT
dti-1295	135	5	ma	ma	PROPN
dti-1295	135	6	,	,	PUNCT
dti-1295	135	7	q.	q.	PROPN
dti-1295	135	8	,	,	PUNCT
dti-1295	135	9	florian	florian	PROPN
dti-1295	135	10	,	,	PUNCT
dti-1295	135	11	m.	m.	NOUN
dti-1295	135	12	,	,	PUNCT
dti-1295	135	13	maddineni	maddineni	PROPN
dti-1295	135	14	,	,	PUNCT
dti-1295	135	15	j.	j.	PROPN
dti-1295	135	16	,	,	PUNCT
dti-1295	135	17	iqbal	iqbal	PROPN
dti-1295	135	18	,	,	PUNCT
dti-1295	135	19	o.	o.	PROPN
dti-1295	135	20	,	,	PUNCT
dti-1295	135	21	hoppensteadt	hoppensteadt	NOUN
dti-1295	135	22	,	,	PUNCT
dti-1295	135	23	d.	d.	PROPN
dti-1295	135	24	and	and	CCONJ
dti-1295	135	25	bick	bick	PROPN
dti-1295	135	26	,	,	PUNCT
dti-1295	135	27	r.l	r.l	PROPN
dti-1295	135	28	.	.	PROPN
dti-1295	135	29	2004	2004	NUM
dti-1295	135	30	.	.	PUNCT
dti-1295	136	1	differentiation	differentiation	NOUN
dti-1295	136	2	of	of	ADP
dti-1295	136	3	low	low	ADJ
dti-1295	136	4	-	-	PUNCT
dti-1295	136	5	molecular	molecular	ADJ
dti-1295	136	6	-	-	PUNCT
dti-1295	136	7	weight	weight	NOUN
dti-1295	136	8	heparins	heparin	NOUN
dti-1295	136	9	:	:	PUNCT
dti-1295	136	10	impact	impact	NOUN
dti-1295	136	11	on	on	ADP
dti-1295	136	12	the	the	DET
dti-1295	136	13	future	future	NOUN
dti-1295	136	14	of	of	ADP
dti-1295	136	15	the	the	DET
dti-1295	136	16	management	management	NOUN
dti-1295	136	17	of	of	ADP
dti-1295	136	18	thrombosis	thrombosis	NOUN
dti-1295	136	19	.	.	PUNCT
dti-1295	137	1	seminars	seminar	NOUN
dti-1295	137	2	in	in	ADP
dti-1295	137	3	thrombosis	thrombosis	NOUN
dti-1295	137	4	and	and	CCONJ
dti-1295	137	5	hemostasis	hemostasis	NOUN
dti-1295	137	6	,	,	PUNCT
dti-1295	137	7	30	30	NUM
dti-1295	137	8	suppl	suppl	ADJ
dti-1295	137	9	.	.	PUNCT
dti-1295	138	1	1:89–104	1:89–104	X
dti-1295	138	2	.	.	PUNCT
dti-1295	139	1	kitchen	kitchen	NOUN
dti-1295	139	2	,	,	PUNCT
dti-1295	139	3	s.	s.	PROPN
dti-1295	139	4	2000	2000	NUM
dti-1295	139	5	.	.	PUNCT
dti-1295	140	1	problems	problem	NOUN
dti-1295	140	2	in	in	ADP
dti-1295	140	3	laboratory	laboratory	NOUN
dti-1295	140	4	monitoring	monitoring	NOUN
dti-1295	140	5	of	of	ADP
dti-1295	140	6	heparin	heparin	ADJ
dti-1295	140	7	dosage	dosage	NOUN
dti-1295	140	8	.	.	PUNCT
dti-1295	141	1	brit	brit	PROPN
dti-1295	141	2	.	.	PUNCT
dti-1295	142	1	j.	j.	PROPN
dti-1295	142	2	haematol	haematol	PROPN
dti-1295	142	3	.	.	PUNCT
dti-1295	142	4	,	,	PUNCT
dti-1295	142	5	111:397–406	111:397–406	NUM
dti-1295	142	6	.	.	PUNCT
dti-1295	143	1	kongsgaard	kongsgaard	PROPN
dti-1295	143	2	,	,	PUNCT
dti-1295	143	3	u.e	u.e	PROPN
dti-1295	143	4	.	.	PROPN
dti-1295	143	5	,	,	PUNCT
dti-1295	143	6	aasen	aasen	PROPN
dti-1295	143	7	,	,	PUNCT
dti-1295	143	8	a.o	a.o	PROPN
dti-1295	143	9	.	.	PROPN
dti-1295	143	10	,	,	PUNCT
dti-1295	143	11	smith	smith	NOUN
dti-1295	143	12	-	-	PUNCT
dti-1295	143	13	erichsen	erichsen	VERB
dti-1295	143	14	,	,	PUNCT
dti-1295	143	15	n.	n.	NOUN
dti-1295	143	16	and	and	CCONJ
dti-1295	143	17	bjornskau	bjornskau	NOUN
dti-1295	143	18	,	,	PUNCT
dti-1295	143	19	l.	l.	PROPN
dti-1295	143	20	1992	1992	NUM
dti-1295	143	21	.	.	PUNCT
dti-1295	144	1	effects	effect	NOUN
dti-1295	144	2	of	of	ADP
dti-1295	144	3	heparin	heparin	NOUN
dti-1295	144	4	on	on	ADP
dti-1295	144	5	proteolytic	proteolytic	ADJ
dti-1295	144	6	activities	activity	NOUN
dti-1295	144	7	in	in	ADP
dti-1295	144	8	human	human	ADJ
dti-1295	144	9	plasma	plasma	NOUN
dti-1295	144	10	.	.	PUNCT
dti-1295	145	1	eur	eur	ADJ
dti-1295	145	2	.	.	PUNCT
dti-1295	145	3	surg	surg	PROPN
dti-1295	145	4	.	.	PUNCT
dti-1295	146	1	res	re	NOUN
dti-1295	146	2	.	.	PROPN
dti-1295	146	3	,	,	PUNCT
dti-1295	146	4	24:119–28	24:119–28	NOUN
dti-1295	146	5	.	.	PUNCT
dti-1295	147	1	lee	lee	PROPN
dti-1295	147	2	,	,	PUNCT
dti-1295	147	3	w.l	w.l	PROPN
dti-1295	147	4	.	.	PROPN
dti-1295	147	5	,	,	PUNCT
dti-1295	147	6	downey	downey	PROPN
dti-1295	147	7	,	,	PUNCT
dti-1295	147	8	g.p	g.p	PROPN
dti-1295	147	9	.	.	PROPN
dti-1295	147	10	2000	2000	NUM
dti-1295	147	11	.	.	PUNCT
dti-1295	148	1	coagulation	coagulation	NOUN
dti-1295	148	2	inhibitors	inhibitor	NOUN
dti-1295	148	3	in	in	ADP
dti-1295	148	4	sepsis	sepsis	NOUN
dti-1295	148	5	and	and	CCONJ
dti-1295	148	6	disseminated	disseminate	VERB
dti-1295	148	7	intravascular	intravascular	ADJ
dti-1295	148	8	coagulation	coagulation	NOUN
dti-1295	148	9	.	.	PUNCT
dti-1295	149	1	intensive	intensive	ADJ
dti-1295	149	2	care	care	NOUN
dti-1295	149	3	medicine	medicine	NOUN
dti-1295	149	4	,	,	PUNCT
dti-1295	149	5	26:1701–1706	26:1701–1706	PROPN
dti-1295	149	6	.	.	PUNCT
dti-1295	149	7	mosesson	mosesson	PROPN
dti-1295	149	8	,	,	PUNCT
dti-1295	149	9	m.w	m.w	PROPN
dti-1295	149	10	.	.	PROPN
dti-1295	149	11	2005	2005	NUM
dti-1295	149	12	.	.	PUNCT
dti-1295	150	1	fibrinogen	fibrinogen	NOUN
dti-1295	150	2	and	and	CCONJ
dti-1295	150	3	fi	fi	NOUN
dti-1295	150	4	brin	brin	PROPN
dti-1295	150	5	structure	structure	NOUN
dti-1295	150	6	and	and	CCONJ
dti-1295	150	7	functions	function	NOUN
dti-1295	150	8	.	.	PUNCT
dti-1295	151	1	j.	j.	PROPN
dti-1295	151	2	thromb	thromb	PROPN
dti-1295	151	3	.	.	PUNCT
dti-1295	152	1	haemost	haemost	PROPN
dti-1295	152	2	.	.	PUNCT
dti-1295	152	3	,	,	PUNCT
dti-1295	152	4	3:1894–904	3:1894–904	PROPN
dti-1295	152	5	.	.	PUNCT
dti-1295	153	1	soriano	soriano	PROPN
dti-1295	153	2	,	,	PUNCT
dti-1295	153	3	a.o	a.o	PROPN
dti-1295	153	4	.	.	PROPN
dti-1295	153	5	,	,	PUNCT
dti-1295	153	6	jy	jy	PROPN
dti-1295	153	7	,	,	PUNCT
dti-1295	153	8	w.	w.	PROPN
dti-1295	153	9	,	,	PUNCT
dti-1295	153	10	chirinos	chirinos	PROPN
dti-1295	153	11	,	,	PUNCT
dti-1295	153	12	j.a	j.a	PROPN
dti-1295	153	13	.	.	PROPN
dti-1295	153	14	,	,	PUNCT
dti-1295	153	15	valdivia	valdivia	PROPN
dti-1295	153	16	,	,	PUNCT
dti-1295	153	17	m.a	m.a	PROPN
dti-1295	153	18	.	.	PROPN
dti-1295	153	19	,	,	PUNCT
dti-1295	153	20	velasquez	velasquez	PROPN
dti-1295	153	21	,	,	PUNCT
dti-1295	153	22	h.s	h.s	PROPN
dti-1295	153	23	.	.	PROPN
dti-1295	153	24	,	,	PUNCT
dti-1295	153	25	jimenez	jimenez	PROPN
dti-1295	153	26	,	,	PUNCT
dti-1295	153	27	j.j	j.j	PROPN
dti-1295	153	28	.	.	PROPN
dti-1295	153	29	,	,	PUNCT
dti-1295	153	30	horstman	horstman	PROPN
dti-1295	153	31	,	,	PUNCT
dti-1295	153	32	l.l	l.l	PROPN
dti-1295	153	33	.	.	PROPN
dti-1295	153	34	,	,	PUNCT
dti-1295	153	35	kett	kett	PROPN
dti-1295	153	36	,	,	PUNCT
dti-1295	153	37	d.h	d.h	PROPN
dti-1295	153	38	.	.	PROPN
dti-1295	153	39	,	,	PUNCT
dti-1295	153	40	schein	schein	PROPN
dti-1295	153	41	,	,	PUNCT
dti-1295	153	42	r.m	r.m	PROPN
dti-1295	153	43	.	.	PROPN
dti-1295	153	44	and	and	CCONJ
dti-1295	153	45	ahn	ahn	PROPN
dti-1295	153	46	,	,	PUNCT
dti-1295	153	47	y.s	y.s	PROPN
dti-1295	153	48	.	.	PROPN
dti-1295	153	49	2005	2005	NUM
dti-1295	153	50	.	.	PUNCT
dti-1295	154	1	levels	level	NOUN
dti-1295	154	2	of	of	ADP
dti-1295	154	3	endothelial	endothelial	ADJ
dti-1295	154	4	and	and	CCONJ
dti-1295	154	5	platelet	platelet	NOUN
dti-1295	154	6	microparticles	microparticle	NOUN
dti-1295	154	7	and	and	CCONJ
dti-1295	154	8	their	their	PRON
dti-1295	154	9	interactions	interaction	NOUN
dti-1295	154	10	with	with	ADP
dti-1295	154	11	leukocytes	leukocyte	NOUN
dti-1295	154	12	negatively	negatively	ADV
dti-1295	154	13	correlate	correlate	VERB
dti-1295	154	14	with	with	ADP
dti-1295	154	15	organ	organ	NOUN
dti-1295	154	16	dysfunction	dysfunction	NOUN
dti-1295	154	17	and	and	CCONJ
dti-1295	154	18	predict	predict	VERB
dti-1295	154	19	mortality	mortality	NOUN
dti-1295	154	20	in	in	ADP
dti-1295	154	21	severe	severe	ADJ
dti-1295	154	22	sepsis	sepsis	NOUN
dti-1295	154	23	.	.	PUNCT
dti-1295	155	1	crit	crit	PROPN
dti-1295	155	2	.	.	PUNCT
dti-1295	155	3	care	care	PROPN
dti-1295	155	4	med	me	VERB
dti-1295	155	5	.	.	PUNCT
dti-1295	156	1	33:2540–2546	33:2540–2546	X
dti-1295	156	2	.	.	PUNCT
dti-1295	157	1	stief	stief	PROPN
dti-1295	157	2	,	,	PUNCT
dti-1295	157	3	t.w	t.w	PROPN
dti-1295	157	4	.	.	PROPN
dti-1295	157	5	2000	2000	NUM
dti-1295	157	6	.	.	PUNCT
dti-1295	158	1	functional	functional	ADJ
dti-1295	158	2	determination	determination	NOUN
dti-1295	158	3	of	of	ADP
dti-1295	158	4	soluble	soluble	ADJ
dti-1295	158	5	fi	fi	NOUN
dti-1295	158	6	brin	brin	PROPN
dti-1295	158	7	polymers	polymers	PROPN
dti-1295	158	8	(	(	PUNCT
dti-1295	158	9	sfp	sfp	PROPN
dti-1295	158	10	)	)	PUNCT
dti-1295	158	11	in	in	ADP
dti-1295	158	12	plasma	plasma	NOUN
dti-1295	158	13	.	.	PUNCT
dti-1295	159	1	thromb	thromb	NOUN
dti-1295	159	2	.	.	PUNCT
dti-1295	160	1	haemost	haemost	PROPN
dti-1295	160	2	.	.	PUNCT
dti-1295	160	3	,	,	PUNCT
dti-1295	160	4	84:1120–1121	84:1120–1121	NUM
dti-1295	160	5	.	.	PUNCT
dti-1295	161	1	stief	stief	PROPN
dti-1295	161	2	,	,	PUNCT
dti-1295	161	3	t.w	t.w	PROPN
dti-1295	161	4	.	.	PROPN
dti-1295	161	5	2006	2006	NUM
dti-1295	161	6	specifi	specifi	PROPN
dti-1295	161	7	c	c	NOUN
dti-1295	161	8	determination	determination	NOUN
dti-1295	161	9	of	of	ADP
dti-1295	161	10	plasmatic	plasmatic	ADJ
dti-1295	161	11	thrombin	thrombin	NOUN
dti-1295	161	12	activity	activity	NOUN
dti-1295	161	13	.	.	PUNCT
dti-1295	162	1	clin	clin	PROPN
dti-1295	162	2	.	.	PUNCT
dti-1295	163	1	appl	appl	PROPN
dti-1295	163	2	.	.	PROPN
dti-1295	163	3	thromb	thromb	PROPN
dti-1295	163	4	.	.	PUNCT
dti-1295	164	1	hemost	hemost	PROPN
dti-1295	164	2	.	.	PUNCT
dti-1295	165	1	,	,	PUNCT
dti-1295	165	2	12:324–329	12:324–329	PROPN
dti-1295	165	3	.	.	PUNCT
dti-1295	166	1	stief	stief	PROPN
dti-1295	166	2	,	,	PUNCT
dti-1295	166	3	t.w	t.w	PROPN
dti-1295	166	4	.	.	PROPN
dti-1295	166	5	,	,	PUNCT
dti-1295	166	6	the	the	DET
dti-1295	166	7	fi	fi	NOUN
dti-1295	166	8	brinogen	brinogen	PROPN
dti-1295	166	9	function	function	PROPN
dti-1295	166	10	turbidimetric	turbidimetric	ADJ
dti-1295	166	11	assay	assay	PROPN
dti-1295	166	12	(	(	PUNCT
dti-1295	166	13	fifta	fifta	PROPN
dti-1295	166	14	)	)	PUNCT
dti-1295	166	15	.	.	PUNCT
dti-1295	167	1	clin	clin	PROPN
dti-1295	167	2	.	.	PUNCT
dti-1295	168	1	appl	appl	PROPN
dti-1295	168	2	.	.	PUNCT
dti-1295	169	1	thrombosis	thrombosis	NOUN
dti-1295	169	2	/	/	SYM
dti-1295	169	3	hemostasis	hemostasis	NOUN
dti-1295	169	4	(	(	PUNCT
dti-1295	169	5	in	in	ADP
dti-1295	169	6	press	press	NOUN
dti-1295	169	7	)	)	PUNCT
dti-1295	169	8	.	.	PUNCT
dti-1295	170	1	stief	stief	PROPN
dti-1295	170	2	,	,	PUNCT
dti-1295	170	3	t.w	t.w	PROPN
dti-1295	170	4	.	.	PROPN
dti-1295	170	5	,	,	PUNCT
dti-1295	170	6	otto	otto	PROPN
dti-1295	170	7	,	,	PUNCT
dti-1295	170	8	s.	s.	PROPN
dti-1295	170	9	and	and	CCONJ
dti-1295	170	10	renz	renz	PROPN
dti-1295	170	11	,	,	PUNCT
dti-1295	170	12	h.	h.	PROPN
dti-1295	170	13	2006	2006	NUM
dti-1295	170	14	.	.	PUNCT
dti-1295	171	1	the	the	DET
dti-1295	171	2	intrinsic	intrinsic	ADJ
dti-1295	171	3	coagulation	coagulation	NOUN
dti-1295	171	4	activity	activity	NOUN
dti-1295	171	5	assay	assay	VERB
dti-1295	171	6	.	.	PUNCT
dti-1295	172	1	blood	blood	NOUN
dti-1295	172	2	coagul	coagul	NOUN
dti-1295	172	3	.	.	PUNCT
dti-1295	173	1	fibrinol	fibrinol	NOUN
dti-1295	173	2	.	.	PUNCT
dti-1295	173	3	,	,	PUNCT
dti-1295	173	4	17:369–78	17:369–78	PROPN
dti-1295	173	5	.	.	PUNCT
dti-1295	174	1	teien	teien	PROPN
dti-1295	174	2	,	,	PUNCT
dti-1295	174	3	a.n	a.n	PROPN
dti-1295	174	4	.	.	PROPN
dti-1295	174	5	,	,	PUNCT
dti-1295	174	6	lie	lie	NOUN
dti-1295	174	7	,	,	PUNCT
dti-1295	174	8	m.	m.	NOUN
dti-1295	174	9	and	and	CCONJ
dti-1295	174	10	abildgaard	abildgaard	NOUN
dti-1295	174	11	,	,	PUNCT
dti-1295	174	12	u.	u.	PROPN
dti-1295	174	13	1976	1976	NUM
dti-1295	174	14	.	.	PUNCT
dti-1295	175	1	assay	assay	NOUN
dti-1295	175	2	of	of	ADP
dti-1295	175	3	heparin	heparin	NOUN
dti-1295	175	4	in	in	ADP
dti-1295	175	5	plasma	plasma	NOUN
dti-1295	175	6	using	use	VERB
dti-1295	175	7	a	a	DET
dti-1295	175	8	chromogenic	chromogenic	ADJ
dti-1295	175	9	substrate	substrate	NOUN
dti-1295	175	10	for	for	ADP
dti-1295	175	11	activated	activated	ADJ
dti-1295	175	12	factor	factor	NOUN
dti-1295	175	13	x.	x.	NOUN
dti-1295	175	14	thromb	thromb	PROPN
dti-1295	175	15	.	.	PUNCT
dti-1295	176	1	res	re	NOUN
dti-1295	176	2	.	.	PROPN
dti-1295	176	3	,	,	PUNCT
dti-1295	176	4	8:413–16	8:413–16	NUM
dti-1295	176	5	.	.	PUNCT
dti-1295	176	6	tobu	tobu	PROPN
dti-1295	176	7	,	,	PUNCT
dti-1295	176	8	m.	m.	NOUN
dti-1295	176	9	,	,	PUNCT
dti-1295	176	10	iqbal	iqbal	PROPN
dti-1295	176	11	,	,	PUNCT
dti-1295	176	12	o.	o.	PROPN
dti-1295	176	13	,	,	PUNCT
dti-1295	176	14	hoppensteadt	hoppensteadt	NOUN
dti-1295	176	15	,	,	PUNCT
dti-1295	176	16	d.	d.	PROPN
dti-1295	176	17	,	,	PUNCT
dti-1295	176	18	neville	neville	PROPN
dti-1295	176	19	b.	b.	PROPN
dti-1295	176	20	,	,	PUNCT
dti-1295	176	21	messmore	messmore	PROPN
dti-1295	176	22	h.l	h.l	PROPN
dti-1295	176	23	.	.	PROPN
dti-1295	176	24	and	and	CCONJ
dti-1295	176	25	fareed	fareed	PROPN
dti-1295	176	26	,	,	PUNCT
dti-1295	176	27	j.	j.	PROPN
dti-1295	176	28	2004	2004	NUM
dti-1295	176	29	.	.	PUNCT
dti-1295	177	1	anti	anti	PROPN
dti-1295	177	2	-	-	PROPN
dti-1295	177	3	xa	xa	PROPN
dti-1295	177	4	and	and	CCONJ
dti-1295	177	5	anti	anti	ADJ
dti-1295	177	6	-	-	ADJ
dti-1295	177	7	iia	iia	ADJ
dti-1295	177	8	drugs	drug	NOUN
dti-1295	177	9	alter	alter	VERB
dti-1295	177	10	international	international	PROPN
dti-1295	177	11	normalized	normalize	VERB
dti-1295	177	12	ratio	ratio	NOUN
dti-1295	177	13	measurements	measurement	NOUN
dti-1295	177	14	:	:	PUNCT
dti-1295	177	15	potential	potential	ADJ
dti-1295	177	16	problems	problem	NOUN
dti-1295	177	17	in	in	ADP
dti-1295	177	18	the	the	DET
dti-1295	177	19	monitoring	monitoring	NOUN
dti-1295	177	20	of	of	ADP
dti-1295	177	21	oral	oral	ADJ
dti-1295	177	22	anticoagulants	anticoagulant	NOUN
dti-1295	177	23	.	.	PUNCT
dti-1295	178	1	clinical	clinical	ADJ
dti-1295	178	2	and	and	CCONJ
dti-1295	178	3	applied	apply	VERB
dti-1295	178	4	thrombosis/	thrombosis/	NUM
dti-1295	178	5	hemostasis	hemostasis	NOUN
dti-1295	178	6	10:301–309	10:301–309	PROPN
dti-1295	178	7	.	.	NOUN
dti-1295	178	8	0	0	NUM
dti-1295	178	9	0.5	0.5	NUM
dti-1295	178	10	1	1	NUM
dti-1295	178	11	1.5	1.5	NUM
dti-1295	178	12	2	2	NUM
dti-1295	178	13	2.5	2.5	NUM
dti-1295	178	14	3	3	NUM
dti-1295	178	15	3.5	3.5	NUM
dti-1295	178	16	4	4	NUM
dti-1295	178	17	4.5	4.5	NUM
dti-1295	178	18	0	0	NUM
dti-1295	178	19	5	5	NUM
dti-1295	178	20	10	10	NUM
dti-1295	178	21	15	15	NUM
dti-1295	178	22	20	20	NUM
dti-1295	178	23	25	25	NUM
dti-1295	178	24	30	30	NUM
dti-1295	178	25	35	35	NUM
dti-1295	178	26	40	40	NUM
dti-1295	178	27	45	45	NUM
dti-1295	178	28	arginine	arginine	NOUN
dti-1295	178	29	conc	conc	NOUN
dti-1295	178	30	.	.	PUNCT
dti-1295	179	1	[	[	X
dti-1295	179	2	mm	mm	X
dti-1295	179	3	]	]	X
dti-1295	179	4	iia	iia	VERB
dti-1295	179	5	a	a	DET
dti-1295	179	6	ct	ct	NOUN
dti-1295	179	7	iv	iv	NOUN
dti-1295	179	8	ity	ity	PROPN
dti-1295	180	1	[	[	X
dti-1295	180	2	i	i	PRON
dti-1295	180	3	u	u	NOUN
dti-1295	180	4	/m	/m	PUNCT
dti-1295	180	5	l	l	NOUN
dti-1295	180	6	]	]	PUNCT
dti-1295	180	7	figure	figure	NOUN
dti-1295	180	8	3b	3b	NUM
dti-1295	180	9	.	.	PUNCT
dti-1295	181	1	4	4	NUM
dti-1295	181	2	min	min	NOUN
dti-1295	181	3	crt	crt	X
dti-1295	181	4	(	(	PUNCT
dti-1295	181	5	▲	▲	NOUN
dti-1295	181	6	)	)	PUNCT
dti-1295	181	7	,	,	PUNCT
dti-1295	181	8	5	5	NUM
dti-1295	181	9	min	min	NOUN
dti-1295	181	10	crt	crt	X
dti-1295	181	11	(	(	PUNCT
dti-1295	181	12	●	●	NOUN
dti-1295	181	13	)	)	PUNCT
dti-1295	181	14	,	,	PUNCT
dti-1295	181	15	6	6	NUM
dti-1295	181	16	min	min	NOUN
dti-1295	181	17	crt	crt	X
dti-1295	181	18	(	(	PUNCT
dti-1295	181	19	■	■	NOUN
dti-1295	181	20	)	)	PUNCT
dti-1295	181	21	,	,	PUNCT
dti-1295	181	22	7	7	NUM
dti-1295	181	23	min	min	NOUN
dti-1295	181	24	crt	crt	X
dti-1295	181	25	(	(	PUNCT
dti-1295	181	26	x	x	NOUN
dti-1295	181	27	)	)	PUNCT
dti-1295	181	28	,	,	PUNCT
dti-1295	181	29	8	8	NUM
dti-1295	181	30	min	min	NOUN
dti-1295	181	31	crt	crt	X
dti-1295	181	32	(	(	PUNCT
dti-1295	181	33	*	*	NOUN
dti-1295	181	34	)	)	PUNCT
dti-1295	181	35	.	.	PUNCT
dti-1295	182	1	drug	drug	NOUN
dti-1295	182	2	target	target	NOUN
dti-1295	182	3	insights	insight	NOUN
dti-1295	182	4	2006:110	2006:110	NUM