id	sid	tid	token	lemma	pos
dti-1301	1	1	untitled	untitled	ADJ
dti-1301	1	2	drug	drug	NOUN
dti-1301	1	3	target	target	NOUN
dti-1301	1	4	insights	insight	NOUN
dti-1301	1	5	2007	2007	NUM
dti-1301	1	6	:	:	PUNCT
dti-1301	1	7	2	2	NUM
dti-1301	1	8	71–81	71–81	NUM
dti-1301	1	9	71	71	NUM
dti-1301	1	10	review	review	NOUN
dti-1301	1	11	correspondence	correspondence	NOUN
dti-1301	1	12	:	:	PUNCT
dti-1301	1	13	j.h	j.h	PROPN
dti-1301	1	14	.	.	PROPN
dti-1301	1	15	hamman	hamman	PROPN
dti-1301	1	16	,	,	PUNCT
dti-1301	1	17	ph.d	ph.d	PROPN
dti-1301	1	18	.	.	PROPN
dti-1301	1	19	,	,	PUNCT
dti-1301	1	20	school	school	NOUN
dti-1301	1	21	of	of	ADP
dti-1301	1	22	pharmacy	pharmacy	NOUN
dti-1301	1	23	,	,	PUNCT
dti-1301	1	24	tshwane	tshwane	NOUN
dti-1301	1	25	university	university	NOUN
dti-1301	1	26	of	of	ADP
dti-1301	1	27	technology	technology	NOUN
dti-1301	1	28	,	,	PUNCT
dti-1301	1	29	private	private	ADJ
dti-1301	1	30	bag	bag	NOUN
dti-1301	1	31	x680	x680	NUM
dti-1301	1	32	,	,	PUNCT
dti-1301	1	33	pretoria	pretoria	NOUN
dti-1301	1	34	,	,	PUNCT
dti-1301	1	35	0001	0001	NUM
dti-1301	1	36	,	,	PUNCT
dti-1301	1	37	south	south	PROPN
dti-1301	1	38	africa	africa	PROPN
dti-1301	1	39	.	.	PUNCT
dti-1301	2	1	tel	tel	ADP
dti-1301	2	2	:	:	PUNCT
dti-1301	2	3	27	27	NUM
dti-1301	2	4	12	12	NUM
dti-1301	2	5	382	382	NUM
dti-1301	2	6	6397	6397	NUM
dti-1301	2	7	;	;	PUNCT
dti-1301	2	8	fax	fax	NOUN
dti-1301	2	9	:	:	PUNCT
dti-1301	2	10	27	27	NUM
dti-1301	2	11	12	12	NUM
dti-1301	2	12	382	382	NUM
dti-1301	2	13	6243	6243	NUM
dti-1301	2	14	;	;	PUNCT
dti-1301	2	15	email	email	NOUN
dti-1301	2	16	:	:	PUNCT
dti-1301	2	17	hammanjh@tut.ac.za	hammanjh@tut.ac.za	ADV
dti-1301	2	18	please	please	INTJ
dti-1301	2	19	note	note	VERB
dti-1301	2	20	that	that	SCONJ
dti-1301	2	21	this	this	DET
dti-1301	2	22	article	article	NOUN
dti-1301	2	23	may	may	AUX
dti-1301	2	24	not	not	PART
dti-1301	2	25	be	be	AUX
dti-1301	2	26	used	use	VERB
dti-1301	2	27	for	for	ADP
dti-1301	2	28	commercial	commercial	ADJ
dti-1301	2	29	purposes	purpose	NOUN
dti-1301	2	30	.	.	PUNCT
dti-1301	3	1	for	for	ADP
dti-1301	3	2	further	further	ADJ
dti-1301	3	3	information	information	NOUN
dti-1301	3	4	please	please	INTJ
dti-1301	3	5	refer	refer	VERB
dti-1301	3	6	to	to	ADP
dti-1301	3	7	the	the	DET
dti-1301	3	8	copyright	copyright	NOUN
dti-1301	3	9	statement	statement	NOUN
dti-1301	3	10	at	at	ADP
dti-1301	3	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1301	3	12	targeting	targeting	NOUN
dti-1301	3	13	receptors	receptor	NOUN
dti-1301	3	14	,	,	PUNCT
dti-1301	3	15	transporters	transporter	NOUN
dti-1301	3	16	and	and	CCONJ
dti-1301	3	17	site	site	NOUN
dti-1301	3	18	of	of	ADP
dti-1301	3	19	absorption	absorption	NOUN
dti-1301	3	20	to	to	PART
dti-1301	3	21	improve	improve	VERB
dti-1301	3	22	oral	oral	ADJ
dti-1301	3	23	drug	drug	NOUN
dti-1301	3	24	delivery	delivery	NOUN
dti-1301	3	25	j.h	j.h	PROPN
dti-1301	3	26	.	.	PROPN
dti-1301	3	27	hamman	hamman	PROPN
dti-1301	3	28	,	,	PUNCT
dti-1301	3	29	p.h	p.h	PROPN
dti-1301	3	30	.	.	PROPN
dti-1301	3	31	demana	demana	PROPN
dti-1301	3	32	and	and	CCONJ
dti-1301	3	33	e.i	e.i	PROPN
dti-1301	3	34	.	.	PROPN
dti-1301	3	35	olivier	olivier	PROPN
dti-1301	3	36	school	school	PROPN
dti-1301	3	37	of	of	ADP
dti-1301	3	38	pharmacy	pharmacy	NOUN
dti-1301	3	39	,	,	PUNCT
dti-1301	3	40	tshwane	tshwane	NOUN
dti-1301	3	41	university	university	NOUN
dti-1301	3	42	of	of	ADP
dti-1301	3	43	technology	technology	NOUN
dti-1301	3	44	,	,	PUNCT
dti-1301	3	45	private	private	ADJ
dti-1301	3	46	bag	bag	NOUN
dti-1301	3	47	x680	x680	NUM
dti-1301	3	48	,	,	PUNCT
dti-1301	3	49	pretoria	pretoria	NOUN
dti-1301	3	50	,	,	PUNCT
dti-1301	3	51	0001	0001	NUM
dti-1301	3	52	,	,	PUNCT
dti-1301	3	53	south	south	PROPN
dti-1301	3	54	africa	africa	PROPN
dti-1301	3	55	.	.	PUNCT
dti-1301	4	1	abstract	abstract	ADJ
dti-1301	4	2	:	:	PUNCT
dti-1301	4	3	although	although	SCONJ
dti-1301	4	4	the	the	DET
dti-1301	4	5	oral	oral	ADJ
dti-1301	4	6	route	route	NOUN
dti-1301	4	7	of	of	ADP
dti-1301	4	8	drug	drug	NOUN
dti-1301	4	9	administration	administration	NOUN
dti-1301	4	10	is	be	AUX
dti-1301	4	11	the	the	DET
dti-1301	4	12	most	most	ADV
dti-1301	4	13	acceptable	acceptable	ADJ
dti-1301	4	14	way	way	NOUN
dti-1301	4	15	of	of	ADP
dti-1301	4	16	self	self	NOUN
dti-1301	4	17	-	-	PUNCT
dti-1301	4	18	medication	medication	NOUN
dti-1301	4	19	with	with	ADP
dti-1301	4	20	a	a	DET
dti-1301	4	21	high	high	ADJ
dti-1301	4	22	degree	degree	NOUN
dti-1301	4	23	of	of	ADP
dti-1301	4	24	patient	patient	ADJ
dti-1301	4	25	compliance	compliance	NOUN
dti-1301	4	26	,	,	PUNCT
dti-1301	4	27	the	the	DET
dti-1301	4	28	intestinal	intestinal	ADJ
dti-1301	4	29	absorption	absorption	NOUN
dti-1301	4	30	of	of	ADP
dti-1301	4	31	many	many	ADJ
dti-1301	4	32	drugs	drug	NOUN
dti-1301	4	33	is	be	AUX
dti-1301	4	34	severely	severely	ADV
dti-1301	4	35	hampered	hamper	VERB
dti-1301	4	36	by	by	ADP
dti-1301	4	37	different	different	ADJ
dti-1301	4	38	biological	biological	ADJ
dti-1301	4	39	barriers	barrier	NOUN
dti-1301	4	40	.	.	PUNCT
dti-1301	5	1	these	these	DET
dti-1301	5	2	barriers	barrier	NOUN
dti-1301	5	3	comprise	comprise	VERB
dti-1301	5	4	of	of	ADP
dti-1301	5	5	biochemical	biochemical	ADJ
dti-1301	5	6	and	and	CCONJ
dti-1301	5	7	physical	physical	ADJ
dti-1301	5	8	components	component	NOUN
dti-1301	5	9	.	.	PUNCT
dti-1301	6	1	the	the	DET
dti-1301	6	2	biochemical	biochemical	ADJ
dti-1301	6	3	barrier	barrier	NOUN
dti-1301	6	4	includes	include	VERB
dti-1301	6	5	enzymatic	enzymatic	ADJ
dti-1301	6	6	degradation	degradation	NOUN
dti-1301	6	7	in	in	ADP
dti-1301	6	8	the	the	DET
dti-1301	6	9	gastrointestinal	gastrointestinal	ADJ
dti-1301	6	10	lumen	luman	NOUN
dti-1301	6	11	,	,	PUNCT
dti-1301	6	12	brush	brush	NOUN
dti-1301	6	13	border	border	NOUN
dti-1301	6	14	and	and	CCONJ
dti-1301	6	15	in	in	ADP
dti-1301	6	16	the	the	DET
dti-1301	6	17	cytoplasm	cytoplasm	NOUN
dti-1301	6	18	of	of	ADP
dti-1301	6	19	the	the	DET
dti-1301	6	20	epithelial	epithelial	ADJ
dti-1301	6	21	cells	cell	NOUN
dti-1301	6	22	as	as	ADV
dti-1301	6	23	well	well	ADV
dti-1301	6	24	as	as	ADP
dti-1301	6	25	effl	effl	PROPN
dti-1301	6	26	ux	ux	PROPN
dti-1301	6	27	transporters	transporter	NOUN
dti-1301	6	28	that	that	PRON
dti-1301	6	29	pump	pump	VERB
dti-1301	6	30	drug	drug	NOUN
dti-1301	6	31	molecules	molecule	NOUN
dti-1301	6	32	from	from	ADP
dti-1301	6	33	inside	inside	ADP
dti-1301	6	34	the	the	DET
dti-1301	6	35	epithelial	epithelial	ADJ
dti-1301	6	36	cell	cell	NOUN
dti-1301	6	37	back	back	ADV
dti-1301	6	38	to	to	ADP
dti-1301	6	39	the	the	DET
dti-1301	6	40	gastrointestinal	gastrointestinal	ADJ
dti-1301	6	41	lumen	luman	NOUN
dti-1301	6	42	.	.	PUNCT
dti-1301	7	1	the	the	DET
dti-1301	7	2	physical	physical	ADJ
dti-1301	7	3	barrier	barrier	NOUN
dti-1301	7	4	consists	consist	VERB
dti-1301	7	5	of	of	ADP
dti-1301	7	6	the	the	DET
dti-1301	7	7	epithelial	epithelial	ADJ
dti-1301	7	8	cell	cell	NOUN
dti-1301	7	9	membranes	membrane	NOUN
dti-1301	7	10	,	,	PUNCT
dti-1301	7	11	tight	tight	ADJ
dti-1301	7	12	junctions	junction	NOUN
dti-1301	7	13	and	and	CCONJ
dti-1301	7	14	mucus	mucus	NOUN
dti-1301	7	15	layer	layer	NOUN
dti-1301	7	16	.	.	PUNCT
dti-1301	8	1	different	different	ADJ
dti-1301	8	2	strategies	strategy	NOUN
dti-1301	8	3	have	have	AUX
dti-1301	8	4	been	be	AUX
dti-1301	8	5	applied	apply	VERB
dti-1301	8	6	to	to	PART
dti-1301	8	7	improve	improve	VERB
dti-1301	8	8	the	the	DET
dti-1301	8	9	absorption	absorption	NOUN
dti-1301	8	10	of	of	ADP
dti-1301	8	11	drugs	drug	NOUN
dti-1301	8	12	after	after	ADP
dti-1301	8	13	oral	oral	ADJ
dti-1301	8	14	administration	administration	NOUN
dti-1301	8	15	,	,	PUNCT
dti-1301	8	16	which	which	PRON
dti-1301	8	17	range	range	VERB
dti-1301	8	18	from	from	ADP
dti-1301	8	19	chemical	chemical	PROPN
dti-1301	8	20	modifi	modifi	PROPN
dti-1301	8	21	cation	cation	NOUN
dti-1301	8	22	of	of	ADP
dti-1301	8	23	drug	drug	NOUN
dti-1301	8	24	molecules	molecule	NOUN
dti-1301	8	25	and	and	CCONJ
dti-1301	8	26	formulation	formulation	NOUN
dti-1301	8	27	technologies	technology	NOUN
dti-1301	8	28	to	to	ADP
dti-1301	8	29	the	the	DET
dti-1301	8	30	targeting	targeting	NOUN
dti-1301	8	31	of	of	ADP
dti-1301	8	32	receptors	receptor	NOUN
dti-1301	8	33	,	,	PUNCT
dti-1301	8	34	transporters	transporter	NOUN
dti-1301	8	35	and	and	CCONJ
dti-1301	8	36	specialized	specialized	ADJ
dti-1301	8	37	cells	cell	NOUN
dti-1301	8	38	such	such	ADJ
dti-1301	8	39	as	as	ADP
dti-1301	8	40	the	the	DET
dti-1301	8	41	gut	gut	NOUN
dti-1301	8	42	-	-	PUNCT
dti-1301	8	43	associated	associate	VERB
dti-1301	8	44	lymphoid	lymphoid	ADJ
dti-1301	8	45	tissues	tissue	NOUN
dti-1301	8	46	.	.	PUNCT
dti-1301	9	1	this	this	DET
dti-1301	9	2	review	review	NOUN
dti-1301	9	3	focuses	focus	VERB
dti-1301	9	4	specifi	specifi	PROPN
dti-1301	9	5	cally	cally	ADV
dti-1301	9	6	on	on	ADP
dti-1301	9	7	the	the	DET
dti-1301	9	8	targeting	targeting	NOUN
dti-1301	9	9	of	of	ADP
dti-1301	9	10	receptor	receptor	NOUN
dti-1301	9	11	-	-	PUNCT
dti-1301	9	12	mediated	mediate	VERB
dti-1301	9	13	endocytosis	endocytosis	NOUN
dti-1301	9	14	,	,	PUNCT
dti-1301	9	15	transporters	transporter	NOUN
dti-1301	9	16	and	and	CCONJ
dti-1301	9	17	the	the	DET
dti-1301	9	18	absorption	absorption	NOUN
dti-1301	9	19	-	-	PUNCT
dti-1301	9	20	site	site	NOUN
dti-1301	9	21	as	as	ADP
dti-1301	9	22	methods	method	NOUN
dti-1301	9	23	of	of	ADP
dti-1301	9	24	optimizing	optimize	VERB
dti-1301	9	25	intestinal	intestinal	ADJ
dti-1301	9	26	drug	drug	NOUN
dti-1301	9	27	absorption	absorption	NOUN
dti-1301	9	28	.	.	PUNCT
dti-1301	10	1	intestinal	intestinal	ADJ
dti-1301	10	2	epithelial	epithelial	ADJ
dti-1301	10	3	cells	cell	NOUN
dti-1301	10	4	express	express	VERB
dti-1301	10	5	several	several	ADJ
dti-1301	10	6	nutrient	nutrient	ADJ
dti-1301	10	7	transporters	transporter	NOUN
dti-1301	10	8	that	that	PRON
dti-1301	10	9	can	can	AUX
dti-1301	10	10	be	be	AUX
dti-1301	10	11	targeted	target	VERB
dti-1301	10	12	by	by	ADP
dti-1301	10	13	modifying	modify	VERB
dti-1301	10	14	the	the	DET
dti-1301	10	15	drug	drug	NOUN
dti-1301	10	16	molecule	molecule	NOUN
dti-1301	10	17	in	in	ADP
dti-1301	10	18	such	such	DET
dti-1301	10	19	a	a	DET
dti-1301	10	20	way	way	NOUN
dti-1301	10	21	that	that	PRON
dti-1301	10	22	it	it	PRON
dti-1301	10	23	is	be	AUX
dti-1301	10	24	recognized	recognize	VERB
dti-1301	10	25	as	as	ADP
dti-1301	10	26	a	a	DET
dti-1301	10	27	substrate	substrate	NOUN
dti-1301	10	28	.	.	PUNCT
dti-1301	11	1	receptor	receptor	NOUN
dti-1301	11	2	-	-	PUNCT
dti-1301	11	3	mediated	mediate	VERB
dti-1301	11	4	endocytosis	endocytosis	NOUN
dti-1301	11	5	is	be	AUX
dti-1301	11	6	a	a	DET
dti-1301	11	7	transport	transport	NOUN
dti-1301	11	8	mechanism	mechanism	NOUN
dti-1301	11	9	that	that	PRON
dti-1301	11	10	can	can	AUX
dti-1301	11	11	be	be	AUX
dti-1301	11	12	targeted	target	VERB
dti-1301	11	13	for	for	ADP
dti-1301	11	14	instance	instance	NOUN
dti-1301	11	15	by	by	ADP
dti-1301	11	16	linking	link	VERB
dti-1301	11	17	a	a	DET
dti-1301	11	18	receptor	receptor	NOUN
dti-1301	11	19	substrate	substrate	NOUN
dti-1301	11	20	to	to	ADP
dti-1301	11	21	the	the	DET
dti-1301	11	22	drug	drug	NOUN
dti-1301	11	23	molecule	molecule	NOUN
dti-1301	11	24	of	of	ADP
dti-1301	11	25	interest	interest	NOUN
dti-1301	11	26	.	.	PUNCT
dti-1301	12	1	many	many	ADJ
dti-1301	12	2	formulation	formulation	NOUN
dti-1301	12	3	strategies	strategy	NOUN
dti-1301	12	4	exist	exist	VERB
dti-1301	12	5	for	for	ADP
dti-1301	12	6	enhancing	enhance	VERB
dti-1301	12	7	drug	drug	NOUN
dti-1301	12	8	absorption	absorption	NOUN
dti-1301	12	9	of	of	ADP
dti-1301	12	10	which	which	PRON
dti-1301	12	11	one	one	NOUN
dti-1301	12	12	is	be	AUX
dti-1301	12	13	to	to	PART
dti-1301	12	14	deliver	deliver	VERB
dti-1301	12	15	drugs	drug	NOUN
dti-1301	12	16	at	at	ADP
dti-1301	12	17	a	a	DET
dti-1301	12	18	specifi	specifi	PROPN
dti-1301	12	19	c	c	PROPN
dti-1301	12	20	site	site	NOUN
dti-1301	12	21	in	in	ADP
dti-1301	12	22	the	the	DET
dti-1301	12	23	gastrointestinal	gastrointestinal	ADJ
dti-1301	12	24	tract	tract	NOUN
dti-1301	12	25	where	where	SCONJ
dti-1301	12	26	optimum	optimum	ADJ
dti-1301	12	27	drug	drug	NOUN
dti-1301	12	28	absorption	absorption	NOUN
dti-1301	12	29	takes	take	VERB
dti-1301	12	30	place	place	NOUN
dti-1301	12	31	.	.	PUNCT
dti-1301	13	1	keywords	keyword	NOUN
dti-1301	13	2	:	:	PUNCT
dti-1301	13	3	oral	oral	ADJ
dti-1301	13	4	drug	drug	NOUN
dti-1301	13	5	delivery	delivery	NOUN
dti-1301	13	6	,	,	PUNCT
dti-1301	13	7	absorption	absorption	NOUN
dti-1301	13	8	enhancement	enhancement	NOUN
dti-1301	13	9	,	,	PUNCT
dti-1301	13	10	receptor	receptor	NOUN
dti-1301	13	11	-	-	PUNCT
dti-1301	13	12	mediated	mediate	VERB
dti-1301	13	13	endocytosis	endocytosis	NOUN
dti-1301	13	14	,	,	PUNCT
dti-1301	13	15	active	active	ADJ
dti-1301	13	16	transporters	transporter	NOUN
dti-1301	13	17	,	,	PUNCT
dti-1301	13	18	site	site	NOUN
dti-1301	13	19	-	-	PUNCT
dti-1301	13	20	specifi	specifi	PROPN
dti-1301	13	21	c	c	PROPN
dti-1301	13	22	drug	drug	NOUN
dti-1301	13	23	delivery	delivery	NOUN
dti-1301	13	24	.	.	PUNCT
dti-1301	14	1	introduction	introduction	NOUN
dti-1301	14	2	oral	oral	ADJ
dti-1301	14	3	delivery	delivery	NOUN
dti-1301	14	4	remains	remain	VERB
dti-1301	14	5	the	the	DET
dti-1301	14	6	most	most	ADV
dti-1301	14	7	favorable	favorable	ADJ
dti-1301	14	8	and	and	CCONJ
dti-1301	14	9	preferred	preferred	ADJ
dti-1301	14	10	route	route	NOUN
dti-1301	14	11	for	for	ADP
dti-1301	14	12	drug	drug	NOUN
dti-1301	14	13	administration	administration	NOUN
dti-1301	14	14	.	.	PUNCT
dti-1301	15	1	currently	currently	ADV
dti-1301	15	2	more	more	ADJ
dti-1301	15	3	than	than	ADP
dti-1301	15	4	60	60	NUM
dti-1301	15	5	%	%	NOUN
dti-1301	15	6	of	of	ADP
dti-1301	15	7	drugs	drug	NOUN
dti-1301	15	8	are	be	AUX
dti-1301	15	9	marketed	market	VERB
dti-1301	15	10	as	as	ADP
dti-1301	15	11	oral	oral	ADJ
dti-1301	15	12	products	product	NOUN
dti-1301	15	13	(	(	PUNCT
dti-1301	15	14	masaoka	masaoka	NOUN
dti-1301	15	15	et	et	PROPN
dti-1301	15	16	al	al	PROPN
dti-1301	15	17	.	.	PROPN
dti-1301	15	18	2006	2006	NUM
dti-1301	15	19	)	)	PUNCT
dti-1301	15	20	.	.	PUNCT
dti-1301	16	1	however	however	ADV
dti-1301	16	2	,	,	PUNCT
dti-1301	16	3	many	many	ADJ
dti-1301	16	4	drugs	drug	NOUN
dti-1301	16	5	can	can	AUX
dti-1301	16	6	not	not	PART
dti-1301	16	7	be	be	AUX
dti-1301	16	8	effectively	effectively	ADV
dti-1301	16	9	delivered	deliver	VERB
dti-1301	16	10	by	by	ADP
dti-1301	16	11	the	the	DET
dti-1301	16	12	oral	oral	ADJ
dti-1301	16	13	route	route	NOUN
dti-1301	16	14	of	of	ADP
dti-1301	16	15	administration	administration	NOUN
dti-1301	16	16	in	in	ADP
dti-1301	16	17	their	their	PRON
dti-1301	16	18	original	original	ADJ
dti-1301	16	19	form	form	NOUN
dti-1301	16	20	due	due	ADP
dti-1301	16	21	to	to	ADP
dti-1301	16	22	reasons	reason	NOUN
dti-1301	16	23	of	of	ADP
dti-1301	16	24	instability	instability	NOUN
dti-1301	16	25	,	,	PUNCT
dti-1301	16	26	low	low	ADJ
dti-1301	16	27	membrane	membrane	NOUN
dti-1301	16	28	permeability	permeability	NOUN
dti-1301	16	29	,	,	PUNCT
dti-1301	16	30	poor	poor	ADJ
dti-1301	16	31	solubility	solubility	NOUN
dti-1301	16	32	and	and	CCONJ
dti-1301	16	33	effl	effl	PROPN
dti-1301	16	34	ux	ux	PROPN
dti-1301	16	35	transport	transport	NOUN
dti-1301	16	36	mechanisms	mechanism	NOUN
dti-1301	16	37	.	.	PUNCT
dti-1301	17	1	overcoming	overcome	VERB
dti-1301	17	2	these	these	DET
dti-1301	17	3	barriers	barrier	NOUN
dti-1301	17	4	is	be	AUX
dti-1301	17	5	currently	currently	ADV
dti-1301	17	6	one	one	NUM
dti-1301	17	7	of	of	ADP
dti-1301	17	8	the	the	DET
dti-1301	17	9	most	most	ADV
dti-1301	17	10	challenging	challenging	ADJ
dti-1301	17	11	goals	goal	NOUN
dti-1301	17	12	in	in	ADP
dti-1301	17	13	oral	oral	ADJ
dti-1301	17	14	drug	drug	NOUN
dti-1301	17	15	delivery	delivery	NOUN
dti-1301	17	16	(	(	PUNCT
dti-1301	17	17	majumdar	majumdar	PROPN
dti-1301	17	18	and	and	CCONJ
dti-1301	17	19	mitra	mitra	PROPN
dti-1301	17	20	,	,	PUNCT
dti-1301	17	21	2006	2006	NUM
dti-1301	17	22	;	;	PUNCT
dti-1301	17	23	leonard	leonard	PROPN
dti-1301	17	24	et	et	PROPN
dti-1301	17	25	al	al	PROPN
dti-1301	17	26	.	.	PROPN
dti-1301	17	27	2006	2006	NUM
dti-1301	17	28	;	;	PUNCT
dti-1301	17	29	hamman	hamman	PROPN
dti-1301	17	30	et	et	PROPN
dti-1301	17	31	al	al	PROPN
dti-1301	17	32	.	.	PROPN
dti-1301	17	33	2005	2005	NUM
dti-1301	17	34	;	;	PUNCT
dti-1301	17	35	ghilzai	ghilzai	NOUN
dti-1301	17	36	,	,	PUNCT
dti-1301	17	37	2004	2004	NUM
dti-1301	17	38	)	)	PUNCT
dti-1301	17	39	.	.	PUNCT
dti-1301	18	1	the	the	DET
dti-1301	18	2	main	main	ADJ
dti-1301	18	3	function	function	NOUN
dti-1301	18	4	of	of	ADP
dti-1301	18	5	the	the	DET
dti-1301	18	6	gastrointestinal	gastrointestinal	ADJ
dti-1301	18	7	tract	tract	NOUN
dti-1301	18	8	is	be	AUX
dti-1301	18	9	to	to	PART
dti-1301	18	10	digest	digest	VERB
dti-1301	18	11	and	and	CCONJ
dti-1301	18	12	absorb	absorb	VERB
dti-1301	18	13	nutrients	nutrient	NOUN
dti-1301	18	14	and	and	CCONJ
dti-1301	18	15	fl	fl	PROPN
dti-1301	18	16	uids	uids	PROPN
dti-1301	18	17	.	.	PUNCT
dti-1301	19	1	in	in	ADP
dti-1301	19	2	addition	addition	NOUN
dti-1301	19	3	,	,	PUNCT
dti-1301	19	4	it	it	PRON
dti-1301	19	5	also	also	ADV
dti-1301	19	6	has	have	VERB
dti-1301	19	7	to	to	PART
dti-1301	19	8	prevent	prevent	VERB
dti-1301	19	9	the	the	DET
dti-1301	19	10	invasion	invasion	NOUN
dti-1301	19	11	of	of	ADP
dti-1301	19	12	toxins	toxin	NOUN
dti-1301	19	13	,	,	PUNCT
dti-1301	19	14	antigens	antigen	NOUN
dti-1301	19	15	and	and	CCONJ
dti-1301	19	16	pathogens	pathogen	NOUN
dti-1301	19	17	.	.	PUNCT
dti-1301	20	1	the	the	DET
dti-1301	20	2	barriers	barrier	NOUN
dti-1301	20	3	that	that	PRON
dti-1301	20	4	exist	exist	VERB
dti-1301	20	5	to	to	PART
dti-1301	20	6	fulfi	fulfi	VERB
dti-1301	20	7	ll	ll	AUX
dti-1301	20	8	this	this	DET
dti-1301	20	9	protective	protective	ADJ
dti-1301	20	10	task	task	NOUN
dti-1301	20	11	are	be	AUX
dti-1301	20	12	also	also	ADV
dti-1301	20	13	responsible	responsible	ADJ
dti-1301	20	14	for	for	ADP
dti-1301	20	15	hampering	hamper	VERB
dti-1301	20	16	the	the	DET
dti-1301	20	17	absorption	absorption	NOUN
dti-1301	20	18	of	of	ADP
dti-1301	20	19	drug	drug	NOUN
dti-1301	20	20	molecules	molecule	NOUN
dti-1301	20	21	after	after	ADP
dti-1301	20	22	oral	oral	ADJ
dti-1301	20	23	administration	administration	NOUN
dti-1301	20	24	.	.	PUNCT
dti-1301	21	1	the	the	DET
dti-1301	21	2	physical	physical	ADJ
dti-1301	21	3	barrier	barrier	NOUN
dti-1301	21	4	of	of	ADP
dti-1301	21	5	the	the	DET
dti-1301	21	6	gastrointestinal	gastrointestinal	ADJ
dti-1301	21	7	tract	tract	NOUN
dti-1301	21	8	can	can	AUX
dti-1301	21	9	be	be	AUX
dti-1301	21	10	attributed	attribute	VERB
dti-1301	21	11	to	to	ADP
dti-1301	21	12	the	the	DET
dti-1301	21	13	cell	cell	NOUN
dti-1301	21	14	membranes	membrane	NOUN
dti-1301	21	15	,	,	PUNCT
dti-1301	21	16	the	the	DET
dti-1301	21	17	tight	tight	ADJ
dti-1301	21	18	junctions	junction	NOUN
dti-1301	21	19	between	between	ADP
dti-1301	21	20	adjacent	adjacent	ADJ
dti-1301	21	21	epithelial	epithelial	ADJ
dti-1301	21	22	cells	cell	NOUN
dti-1301	21	23	and	and	CCONJ
dti-1301	21	24	the	the	DET
dti-1301	21	25	mucus	mucus	NOUN
dti-1301	21	26	layer	layer	NOUN
dti-1301	21	27	,	,	PUNCT
dti-1301	21	28	while	while	SCONJ
dti-1301	21	29	the	the	DET
dti-1301	21	30	biochemical	biochemical	ADJ
dti-1301	21	31	barrier	barrier	NOUN
dti-1301	21	32	comprises	comprise	NOUN
dti-1301	21	33	of	of	ADP
dti-1301	21	34	the	the	DET
dti-1301	21	35	catabolic	catabolic	ADJ
dti-1301	21	36	enzymes	enzyme	NOUN
dti-1301	21	37	and	and	CCONJ
dti-1301	21	38	effl	effl	PROPN
dti-1301	21	39	ux	ux	PROPN
dti-1301	21	40	systems	system	NOUN
dti-1301	21	41	that	that	PRON
dti-1301	21	42	pump	pump	VERB
dti-1301	21	43	molecules	molecule	NOUN
dti-1301	21	44	back	back	ADV
dti-1301	21	45	into	into	ADP
dti-1301	21	46	the	the	DET
dti-1301	21	47	gastrointestinal	gastrointestinal	ADJ
dti-1301	21	48	lumen	luman	NOUN
dti-1301	21	49	(	(	PUNCT
dti-1301	21	50	hunter	hunter	NOUN
dti-1301	21	51	and	and	CCONJ
dti-1301	21	52	hirst	hirst	PROPN
dti-1301	21	53	,	,	PUNCT
dti-1301	21	54	1997	1997	NUM
dti-1301	21	55	;	;	PUNCT
dti-1301	21	56	lennernäs	lennernäs	PROPN
dti-1301	21	57	,	,	PUNCT
dti-1301	21	58	1998	1998	NUM
dti-1301	21	59	;	;	PUNCT
dti-1301	21	60	gabor	gabor	PROPN
dti-1301	21	61	et	et	PROPN
dti-1301	21	62	al	al	PROPN
dti-1301	21	63	.	.	PROPN
dti-1301	21	64	2004	2004	NUM
dti-1301	21	65	)	)	PUNCT
dti-1301	21	66	.	.	PUNCT
dti-1301	22	1	the	the	DET
dti-1301	22	2	barrier	barrier	NOUN
dti-1301	22	3	function	function	NOUN
dti-1301	22	4	of	of	ADP
dti-1301	22	5	the	the	DET
dti-1301	22	6	gastrointestinal	gastrointestinal	ADJ
dti-1301	22	7	tract	tract	NOUN
dti-1301	22	8	is	be	AUX
dti-1301	22	9	schematically	schematically	NOUN
dti-1301	22	10	illustrated	illustrate	VERB
dti-1301	22	11	in	in	ADP
dti-1301	22	12	figure	figure	NOUN
dti-1301	22	13	1	1	NUM
dti-1301	22	14	.	.	PUNCT
dti-1301	23	1	the	the	DET
dti-1301	23	2	implications	implication	NOUN
dti-1301	23	3	of	of	ADP
dti-1301	23	4	a	a	DET
dti-1301	23	5	barrier	barrier	NOUN
dti-1301	23	6	against	against	ADP
dti-1301	23	7	drug	drug	NOUN
dti-1301	23	8	absorption	absorption	NOUN
dti-1301	23	9	from	from	ADP
dti-1301	23	10	the	the	DET
dti-1301	23	11	gastrointestinal	gastrointestinal	ADJ
dti-1301	23	12	tract	tract	NOUN
dti-1301	23	13	include	include	VERB
dti-1301	23	14	low	low	ADJ
dti-1301	23	15	drug	drug	NOUN
dti-1301	23	16	bioavailability	bioavailability	NOUN
dti-1301	23	17	after	after	ADP
dti-1301	23	18	oral	oral	ADJ
dti-1301	23	19	administration	administration	NOUN
dti-1301	23	20	.	.	PUNCT
dti-1301	24	1	when	when	SCONJ
dti-1301	24	2	the	the	DET
dti-1301	24	3	bioavailability	bioavailability	NOUN
dti-1301	24	4	of	of	ADP
dti-1301	24	5	a	a	DET
dti-1301	24	6	drug	drug	NOUN
dti-1301	24	7	is	be	AUX
dti-1301	24	8	low	low	ADJ
dti-1301	24	9	,	,	PUNCT
dti-1301	24	10	it	it	PRON
dti-1301	24	11	is	be	AUX
dti-1301	24	12	most	most	ADV
dti-1301	24	13	likely	likely	ADJ
dti-1301	24	14	that	that	SCONJ
dti-1301	24	15	insuffi	insuffi	PROPN
dti-1301	24	16	cient	cient	NOUN
dti-1301	24	17	drug	drug	NOUN
dti-1301	24	18	will	will	AUX
dti-1301	24	19	become	become	VERB
dti-1301	24	20	available	available	ADJ
dti-1301	24	21	at	at	ADP
dti-1301	24	22	the	the	DET
dti-1301	24	23	site	site	NOUN
dti-1301	24	24	of	of	ADP
dti-1301	24	25	action	action	NOUN
dti-1301	24	26	and	and	CCONJ
dti-1301	24	27	it	it	PRON
dti-1301	24	28	will	will	AUX
dti-1301	24	29	therefore	therefore	ADV
dti-1301	24	30	also	also	ADV
dti-1301	24	31	not	not	PART
dti-1301	24	32	produce	produce	VERB
dti-1301	24	33	its	its	PRON
dti-1301	24	34	pharmacological	pharmacological	ADJ
dti-1301	24	35	effect	effect	NOUN
dti-1301	24	36	(	(	PUNCT
dti-1301	24	37	aungst	aungst	PROPN
dti-1301	24	38	,	,	PUNCT
dti-1301	24	39	1993	1993	NUM
dti-1301	24	40	;	;	PUNCT
dti-1301	24	41	aungst	aungst	PROPN
dti-1301	24	42	,	,	PUNCT
dti-1301	24	43	2000	2000	NUM
dti-1301	24	44	)	)	PUNCT
dti-1301	24	45	.	.	PUNCT
dti-1301	25	1	several	several	ADJ
dti-1301	25	2	strategies	strategy	NOUN
dti-1301	25	3	have	have	AUX
dti-1301	25	4	been	be	AUX
dti-1301	25	5	employed	employ	VERB
dti-1301	25	6	to	to	PART
dti-1301	25	7	improve	improve	VERB
dti-1301	25	8	the	the	DET
dti-1301	25	9	bioavailability	bioavailability	NOUN
dti-1301	25	10	of	of	ADP
dti-1301	25	11	drugs	drug	NOUN
dti-1301	25	12	after	after	ADP
dti-1301	25	13	oral	oral	ADJ
dti-1301	25	14	administration	administration	NOUN
dti-1301	25	15	.	.	PUNCT
dti-1301	26	1	some	some	DET
dti-1301	26	2	strategies	strategy	NOUN
dti-1301	26	3	aim	aim	VERB
dti-1301	26	4	at	at	ADP
dti-1301	26	5	maximizing	maximize	VERB
dti-1301	26	6	the	the	DET
dti-1301	26	7	intestinal	intestinal	ADJ
dti-1301	26	8	uptake	uptake	NOUN
dti-1301	26	9	while	while	SCONJ
dti-1301	26	10	others	other	NOUN
dti-1301	26	11	focus	focus	VERB
dti-1301	26	12	on	on	ADP
dti-1301	26	13	protecting	protect	VERB
dti-1301	26	14	the	the	DET
dti-1301	26	15	drug	drug	NOUN
dti-1301	26	16	molecules	molecule	NOUN
dti-1301	26	17	from	from	ADP
dti-1301	26	18	degradation	degradation	NOUN
dti-1301	26	19	,	,	PUNCT
dti-1301	26	20	but	but	CCONJ
dti-1301	26	21	combinations	combination	NOUN
dti-1301	26	22	there	there	ADV
dti-1301	26	23	of	of	ADP
dti-1301	26	24	have	have	AUX
dti-1301	26	25	also	also	ADV
dti-1301	26	26	been	be	AUX
dti-1301	26	27	reported	report	VERB
dti-1301	26	28	.	.	PUNCT
dti-1301	27	1	these	these	DET
dti-1301	27	2	strategies	strategy	NOUN
dti-1301	27	3	include	include	VERB
dti-1301	27	4	the	the	DET
dti-1301	27	5	formation	formation	NOUN
dti-1301	27	6	of	of	ADP
dti-1301	27	7	pro	pro	ADJ
dti-1301	27	8	-	-	ADJ
dti-1301	27	9	drugs	drug	NOUN
dti-1301	27	10	and/or	and/or	CCONJ
dti-1301	27	11	drug	drug	NOUN
dti-1301	27	12	conjugates	conjugate	NOUN
dti-1301	27	13	,	,	PUNCT
dti-1301	27	14	modifying	modify	VERB
dti-1301	27	15	the	the	DET
dti-1301	27	16	chemical	chemical	ADJ
dti-1301	27	17	structure	structure	NOUN
dti-1301	27	18	of	of	ADP
dti-1301	27	19	the	the	DET
dti-1301	27	20	drug	drug	NOUN
dti-1301	27	21	and	and	CCONJ
dti-1301	27	22	drug	drug	NOUN
dti-1301	27	23	target	target	NOUN
dti-1301	27	24	insights	insight	NOUN
dti-1301	27	25	2007	2007	NUM
dti-1301	27	26	:	:	PUNCT
dti-1301	27	27	272	272	NUM
dti-1301	27	28	hamman	hamman	PROPN
dti-1301	27	29	et	et	PROPN
dti-1301	27	30	al	al	PROPN
dti-1301	27	31	formulation	formulation	PROPN
dti-1301	27	32	design	design	NOUN
dti-1301	27	33	approaches	approach	NOUN
dti-1301	27	34	(	(	PUNCT
dti-1301	27	35	gomez	gomez	PROPN
dti-1301	27	36	-	-	PUNCT
dti-1301	27	37	orellana	orellana	PROPN
dti-1301	27	38	,	,	PUNCT
dti-1301	27	39	2005	2005	NUM
dti-1301	27	40	)	)	PUNCT
dti-1301	27	41	.	.	PUNCT
dti-1301	28	1	although	although	SCONJ
dti-1301	28	2	some	some	PRON
dti-1301	28	3	of	of	ADP
dti-1301	28	4	these	these	DET
dti-1301	28	5	approaches	approach	NOUN
dti-1301	28	6	have	have	AUX
dti-1301	28	7	been	be	AUX
dti-1301	28	8	demonstrated	demonstrate	VERB
dti-1301	28	9	to	to	PART
dti-1301	28	10	be	be	AUX
dti-1301	28	11	successful	successful	ADJ
dti-1301	28	12	in	in	ADP
dti-1301	28	13	laboratory	laboratory	NOUN
dti-1301	28	14	scale	scale	NOUN
dti-1301	28	15	research	research	NOUN
dti-1301	28	16	,	,	PUNCT
dti-1301	28	17	they	they	PRON
dti-1301	28	18	still	still	ADV
dti-1301	28	19	present	present	VERB
dti-1301	28	20	challenges	challenge	NOUN
dti-1301	28	21	in	in	ADP
dti-1301	28	22	terms	term	NOUN
dti-1301	28	23	of	of	ADP
dti-1301	28	24	long	long	ADJ
dti-1301	28	25	-	-	PUNCT
dti-1301	28	26	term	term	NOUN
dti-1301	28	27	safety	safety	NOUN
dti-1301	28	28	and	and	CCONJ
dti-1301	28	29	reproducibility	reproducibility	NOUN
dti-1301	28	30	in	in	ADP
dti-1301	28	31	the	the	DET
dti-1301	28	32	clinical	clinical	ADJ
dti-1301	28	33	situation	situation	NOUN
dti-1301	28	34	.	.	PUNCT
dti-1301	29	1	morishita	morishita	NOUN
dti-1301	29	2	and	and	CCONJ
dti-1301	29	3	peppas	peppa	NOUN
dti-1301	29	4	(	(	PUNCT
dti-1301	29	5	2006	2006	NUM
dti-1301	29	6	)	)	PUNCT
dti-1301	29	7	suggested	suggest	VERB
dti-1301	29	8	that	that	SCONJ
dti-1301	29	9	the	the	DET
dti-1301	29	10	development	development	NOUN
dti-1301	29	11	of	of	ADP
dti-1301	29	12	an	an	DET
dti-1301	29	13	effective	effective	ADJ
dti-1301	29	14	oral	oral	ADJ
dti-1301	29	15	delivery	delivery	NOUN
dti-1301	29	16	system	system	NOUN
dti-1301	29	17	for	for	ADP
dti-1301	29	18	a	a	DET
dti-1301	29	19	new	new	ADJ
dti-1301	29	20	generation	generation	NOUN
dti-1301	29	21	of	of	ADP
dti-1301	29	22	macromolecular	macromolecular	ADJ
dti-1301	29	23	drugs	drug	NOUN
dti-1301	29	24	should	should	AUX
dti-1301	29	25	consider	consider	VERB
dti-1301	29	26	the	the	DET
dti-1301	29	27	following	follow	VERB
dti-1301	29	28	three	three	NUM
dti-1301	29	29	approaches	approach	NOUN
dti-1301	29	30	:	:	PUNCT
dti-1301	29	31	modifi	modifi	NOUN
dti-1301	29	32	cation	cation	NOUN
dti-1301	29	33	of	of	ADP
dti-1301	29	34	a	a	DET
dti-1301	29	35	physicochemical	physicochemical	ADJ
dti-1301	29	36	property	property	NOUN
dti-1301	29	37	of	of	ADP
dti-1301	29	38	the	the	DET
dti-1301	29	39	drug	drug	NOUN
dti-1301	29	40	molecule	molecule	NOUN
dti-1301	29	41	(	(	PUNCT
dti-1301	29	42	e.g.	e.g.	ADV
dti-1301	29	43	lipophilicity	lipophilicity	NOUN
dti-1301	29	44	and	and	CCONJ
dti-1301	29	45	enzyme	enzyme	NOUN
dti-1301	29	46	susceptibility	susceptibility	NOUN
dti-1301	29	47	)	)	PUNCT
dti-1301	29	48	or	or	CCONJ
dti-1301	29	49	addition	addition	NOUN
dti-1301	29	50	of	of	ADP
dti-1301	29	51	novel	novel	ADJ
dti-1301	29	52	functionality	functionality	NOUN
dti-1301	29	53	(	(	PUNCT
dti-1301	29	54	e.g.	e.g.	ADV
dti-1301	29	55	receptor	receptor	NOUN
dti-1301	29	56	recognition	recognition	NOUN
dti-1301	29	57	or	or	CCONJ
dti-1301	29	58	cell	cell	NOUN
dti-1301	29	59	permeability	permeability	NOUN
dti-1301	29	60	)	)	PUNCT
dti-1301	29	61	or	or	CCONJ
dti-1301	29	62	the	the	DET
dti-1301	29	63	use	use	NOUN
dti-1301	29	64	of	of	ADP
dti-1301	29	65	a	a	DET
dti-1301	29	66	novel	novel	ADJ
dti-1301	29	67	drug	drug	NOUN
dti-1301	29	68	delivery	delivery	NOUN
dti-1301	29	69	carrier	carrier	NOUN
dti-1301	29	70	system	system	NOUN
dti-1301	29	71	.	.	PUNCT
dti-1301	30	1	these	these	DET
dti-1301	30	2	strategies	strategy	NOUN
dti-1301	30	3	may	may	AUX
dti-1301	30	4	be	be	AUX
dti-1301	30	5	applied	apply	VERB
dti-1301	30	6	alone	alone	ADJ
dti-1301	30	7	or	or	CCONJ
dti-1301	30	8	in	in	ADP
dti-1301	30	9	combination	combination	NOUN
dti-1301	30	10	to	to	PART
dti-1301	30	11	provide	provide	VERB
dti-1301	30	12	a	a	DET
dti-1301	30	13	solution	solution	NOUN
dti-1301	30	14	to	to	ADP
dti-1301	30	15	the	the	DET
dti-1301	30	16	problem	problem	NOUN
dti-1301	30	17	of	of	ADP
dti-1301	30	18	poor	poor	ADJ
dti-1301	30	19	bioavailability	bioavailability	NOUN
dti-1301	30	20	.	.	PUNCT
dti-1301	31	1	since	since	SCONJ
dti-1301	31	2	it	it	PRON
dti-1301	31	3	is	be	AUX
dti-1301	31	4	desirable	desirable	ADJ
dti-1301	31	5	that	that	SCONJ
dti-1301	31	6	efforts	effort	NOUN
dti-1301	31	7	do	do	AUX
dti-1301	31	8	not	not	PART
dti-1301	31	9	compromise	compromise	VERB
dti-1301	31	10	the	the	DET
dti-1301	31	11	integrity	integrity	NOUN
dti-1301	31	12	of	of	ADP
dti-1301	31	13	the	the	DET
dti-1301	31	14	intestinal	intestinal	ADJ
dti-1301	31	15	mucosa	mucosa	NOUN
dti-1301	31	16	(	(	PUNCT
dti-1301	31	17	both	both	CCONJ
dti-1301	31	18	tight	tight	ADJ
dti-1301	31	19	junctions	junction	NOUN
dti-1301	31	20	and	and	CCONJ
dti-1301	31	21	cell	cell	NOUN
dti-1301	31	22	membranes	membrane	NOUN
dti-1301	31	23	)	)	PUNCT
dti-1301	31	24	,	,	PUNCT
dti-1301	31	25	more	more	ADV
dti-1301	31	26	safe	safe	ADJ
dti-1301	31	27	and	and	CCONJ
dti-1301	31	28	practical	practical	ADJ
dti-1301	31	29	approaches	approach	NOUN
dti-1301	31	30	seem	seem	VERB
dti-1301	31	31	to	to	PART
dti-1301	31	32	be	be	AUX
dti-1301	31	33	targeting	target	VERB
dti-1301	31	34	of	of	ADP
dti-1301	31	35	receptors	receptor	NOUN
dti-1301	31	36	,	,	PUNCT
dti-1301	31	37	transporters	transporter	NOUN
dti-1301	31	38	or	or	CCONJ
dti-1301	31	39	absorption	absorption	NOUN
dti-1301	31	40	sites	site	NOUN
dti-1301	31	41	in	in	ADP
dti-1301	31	42	the	the	DET
dti-1301	31	43	gastrointestinal	gastrointestinal	ADJ
dti-1301	31	44	tract	tract	NOUN
dti-1301	31	45	in	in	ADP
dti-1301	31	46	terms	term	NOUN
dti-1301	31	47	of	of	ADP
dti-1301	31	48	enhancing	enhance	VERB
dti-1301	31	49	the	the	DET
dti-1301	31	50	absorption	absorption	NOUN
dti-1301	31	51	of	of	ADP
dti-1301	31	52	drugs	drug	NOUN
dti-1301	31	53	with	with	ADP
dti-1301	31	54	poor	poor	ADJ
dti-1301	31	55	bioavailabilities	bioavailabilitie	NOUN
dti-1301	31	56	.	.	PUNCT
dti-1301	32	1	these	these	DET
dti-1301	32	2	appealing	appealing	ADJ
dti-1301	32	3	approaches	approach	NOUN
dti-1301	32	4	for	for	ADP
dti-1301	32	5	optimizing	optimize	VERB
dti-1301	32	6	oral	oral	ADJ
dti-1301	32	7	drug	drug	NOUN
dti-1301	32	8	delivery	delivery	NOUN
dti-1301	32	9	will	will	AUX
dti-1301	32	10	be	be	AUX
dti-1301	32	11	the	the	DET
dti-1301	32	12	focus	focus	NOUN
dti-1301	32	13	of	of	ADP
dti-1301	32	14	the	the	DET
dti-1301	32	15	discussions	discussion	NOUN
dti-1301	32	16	in	in	ADP
dti-1301	32	17	this	this	DET
dti-1301	32	18	review	review	NOUN
dti-1301	32	19	.	.	PUNCT
dti-1301	33	1	receptor	receptor	NOUN
dti-1301	33	2	-	-	PUNCT
dti-1301	33	3	mediated	mediate	VERB
dti-1301	33	4	endocytosis	endocytosis	NOUN
dti-1301	33	5	the	the	DET
dti-1301	33	6	pharmacological	pharmacological	ADJ
dti-1301	33	7	effects	effect	NOUN
dti-1301	33	8	of	of	ADP
dti-1301	33	9	a	a	DET
dti-1301	33	10	large	large	ADJ
dti-1301	33	11	number	number	NOUN
dti-1301	33	12	of	of	ADP
dti-1301	33	13	macromolecules	macromolecule	NOUN
dti-1301	33	14	such	such	ADJ
dti-1301	33	15	as	as	ADP
dti-1301	33	16	proteins	protein	NOUN
dti-1301	33	17	and	and	CCONJ
dti-1301	33	18	oligonucleotides	oligonucleotide	NOUN
dti-1301	33	19	for	for	ADP
dti-1301	33	20	the	the	DET
dti-1301	33	21	treatment	treatment	NOUN
dti-1301	33	22	of	of	ADP
dti-1301	33	23	several	several	ADJ
dti-1301	33	24	human	human	ADJ
dti-1301	33	25	diseases	disease	NOUN
dti-1301	33	26	are	be	AUX
dti-1301	33	27	determined	determine	VERB
dti-1301	33	28	by	by	ADP
dti-1301	33	29	many	many	ADJ
dti-1301	33	30	factors	factor	NOUN
dti-1301	33	31	,	,	PUNCT
dti-1301	33	32	including	include	VERB
dti-1301	33	33	receptor	receptor	NOUN
dti-1301	33	34	binding	bind	VERB
dti-1301	33	35	,	,	PUNCT
dti-1301	33	36	cellular	cellular	ADJ
dti-1301	33	37	internalization	internalization	NOUN
dti-1301	33	38	,	,	PUNCT
dti-1301	33	39	intracellular	intracellular	ADJ
dti-1301	33	40	sorting	sorting	NOUN
dti-1301	33	41	and	and	CCONJ
dti-1301	33	42	targeting	target	VERB
dti-1301	33	43	as	as	ADV
dti-1301	33	44	well	well	ADV
dti-1301	33	45	as	as	ADP
dti-1301	33	46	transcellular	transcellular	NOUN
dti-1301	33	47	transport	transport	NOUN
dti-1301	33	48	.	.	PUNCT
dti-1301	34	1	therefore	therefore	ADV
dti-1301	34	2	,	,	PUNCT
dti-1301	34	3	the	the	DET
dti-1301	34	4	therapeutic	therapeutic	ADJ
dti-1301	34	5	applications	application	NOUN
dti-1301	34	6	of	of	ADP
dti-1301	34	7	most	most	ADJ
dti-1301	34	8	proteins	protein	NOUN
dti-1301	34	9	and	and	CCONJ
dti-1301	34	10	macromolecular	macromolecular	NOUN
dti-1301	34	11	drugs	drug	NOUN
dti-1301	34	12	depend	depend	VERB
dti-1301	34	13	largely	largely	ADV
dti-1301	34	14	on	on	ADP
dti-1301	34	15	their	their	PRON
dti-1301	34	16	ability	ability	NOUN
dti-1301	34	17	to	to	PART
dti-1301	34	18	be	be	AUX
dti-1301	34	19	endocytosed	endocytose	VERB
dti-1301	34	20	(	(	PUNCT
dti-1301	34	21	shen	shen	PROPN
dti-1301	34	22	et	et	PROPN
dti-1301	34	23	al	al	PROPN
dti-1301	34	24	.	.	PROPN
dti-1301	34	25	1992	1992	NUM
dti-1301	34	26	)	)	PUNCT
dti-1301	34	27	.	.	PUNCT
dti-1301	35	1	the	the	DET
dti-1301	35	2	main	main	ADJ
dti-1301	35	3	mechanism	mechanism	NOUN
dti-1301	35	4	important	important	ADJ
dti-1301	35	5	in	in	ADP
dti-1301	35	6	this	this	DET
dti-1301	35	7	regard	regard	NOUN
dti-1301	35	8	is	be	AUX
dti-1301	35	9	known	know	VERB
dti-1301	35	10	as	as	ADP
dti-1301	35	11	receptor	receptor	NOUN
dti-1301	35	12	-	-	PUNCT
dti-1301	35	13	mediated	mediate	VERB
dti-1301	35	14	endocytosis	endocytosis	NOUN
dti-1301	35	15	.	.	PUNCT
dti-1301	36	1	receptor	receptor	NOUN
dti-1301	36	2	-	-	PUNCT
dti-1301	36	3	mediated	mediate	VERB
dti-1301	36	4	endocytosis	endocytosis	NOUN
dti-1301	36	5	is	be	AUX
dti-1301	36	6	a	a	DET
dti-1301	36	7	process	process	NOUN
dti-1301	36	8	of	of	ADP
dti-1301	36	9	internalization	internalization	NOUN
dti-1301	36	10	of	of	ADP
dti-1301	36	11	extracellular	extracellular	ADJ
dti-1301	36	12	molecules	molecule	NOUN
dti-1301	36	13	during	during	ADP
dti-1301	36	14	which	which	PRON
dti-1301	36	15	binding	bind	VERB
dti-1301	36	16	occurs	occur	VERB
dti-1301	36	17	between	between	ADP
dti-1301	36	18	these	these	DET
dti-1301	36	19	molecules	molecule	NOUN
dti-1301	36	20	and	and	CCONJ
dti-1301	36	21	the	the	DET
dti-1301	36	22	receptors	receptor	NOUN
dti-1301	36	23	.	.	PUNCT
dti-1301	37	1	the	the	DET
dti-1301	37	2	receptors	receptor	NOUN
dti-1301	37	3	are	be	AUX
dti-1301	37	4	considered	consider	VERB
dti-1301	37	5	as	as	ADP
dti-1301	37	6	membrane	membrane	NOUN
dti-1301	37	7	-	-	PUNCT
dti-1301	37	8	associated	associate	VERB
dti-1301	37	9	proteins	protein	NOUN
dti-1301	37	10	and	and	CCONJ
dti-1301	37	11	the	the	DET
dti-1301	37	12	intracellular	intracellular	ADJ
dti-1301	37	13	molecules	molecule	NOUN
dti-1301	37	14	which	which	PRON
dti-1301	37	15	specifi	specifi	VERB
dti-1301	37	16	cally	cally	ADV
dti-1301	37	17	bind	bind	VERB
dti-1301	37	18	to	to	ADP
dti-1301	37	19	these	these	DET
dti-1301	37	20	receptors	receptor	NOUN
dti-1301	37	21	are	be	AUX
dti-1301	37	22	known	know	VERB
dti-1301	37	23	as	as	ADP
dti-1301	37	24	ligands	ligand	NOUN
dti-1301	37	25	(	(	PUNCT
dti-1301	37	26	shen	shen	NOUN
dti-1301	37	27	et	et	PROPN
dti-1301	37	28	al	al	PROPN
dti-1301	37	29	.	.	PROPN
dti-1301	37	30	1992	1992	NUM
dti-1301	37	31	)	)	PUNCT
dti-1301	37	32	.	.	PUNCT
dti-1301	38	1	following	follow	VERB
dti-1301	38	2	binding	bind	VERB
dti-1301	38	3	to	to	ADP
dti-1301	38	4	the	the	DET
dti-1301	38	5	receptor	receptor	NOUN
dti-1301	38	6	on	on	ADP
dti-1301	38	7	the	the	DET
dti-1301	38	8	cell	cell	NOUN
dti-1301	38	9	surface	surface	NOUN
dti-1301	38	10	,	,	PUNCT
dti-1301	38	11	the	the	DET
dti-1301	38	12	resultant	resultant	NOUN
dti-1301	38	13	ligand	ligand	NOUN
dti-1301	38	14	-	-	PUNCT
dti-1301	38	15	receptor	receptor	NOUN
dti-1301	38	16	complex	complex	NOUN
dti-1301	38	17	is	be	AUX
dti-1301	38	18	internalized	internalize	VERB
dti-1301	38	19	via	via	ADP
dti-1301	38	20	a	a	DET
dti-1301	38	21	clathrin	clathrin	NOUN
dti-1301	38	22	-	-	PUNCT
dti-1301	38	23	dependent	dependent	ADJ
dti-1301	38	24	or	or	CCONJ
dti-1301	38	25	a	a	DET
dti-1301	38	26	clathrinindependent	clathrinindependent	ADJ
dti-1301	38	27	endocytotic	endocytotic	ADJ
dti-1301	38	28	process	process	NOUN
dti-1301	38	29	.	.	PUNCT
dti-1301	39	1	in	in	ADP
dti-1301	39	2	the	the	DET
dti-1301	39	3	clathrin	clathrin	NOUN
dti-1301	39	4	-	-	PUNCT
dti-1301	39	5	dependent	dependent	ADJ
dti-1301	39	6	pathway	pathway	NOUN
dti-1301	39	7	,	,	PUNCT
dti-1301	39	8	the	the	DET
dti-1301	39	9	formation	formation	NOUN
dti-1301	39	10	of	of	ADP
dti-1301	39	11	ligand	ligand	NOUN
dti-1301	39	12	-	-	PUNCT
dti-1301	39	13	receptor	receptor	NOUN
dti-1301	39	14	complex	complex	NOUN
dti-1301	39	15	is	be	AUX
dti-1301	39	16	followed	follow	VERB
dti-1301	39	17	by	by	ADP
dti-1301	39	18	concentration	concentration	NOUN
dti-1301	39	19	in	in	ADP
dti-1301	39	20	clathrin	clathrin	NOUN
dti-1301	39	21	-	-	PUNCT
dti-1301	39	22	coated	coat	VERB
dti-1301	39	23	regions	region	NOUN
dti-1301	39	24	or	or	CCONJ
dti-1301	39	25	coated	coated	ADJ
dti-1301	39	26	pits	pit	NOUN
dti-1301	39	27	of	of	ADP
dti-1301	39	28	the	the	DET
dti-1301	39	29	plasma	plasma	NOUN
dti-1301	39	30	membrane	membrane	NOUN
dti-1301	39	31	.	.	PUNCT
dti-1301	40	1	these	these	DET
dti-1301	40	2	coated	coat	VERB
dti-1301	40	3	pits	pit	NOUN
dti-1301	40	4	invaginate	invaginate	ADJ
dti-1301	40	5	from	from	ADP
dti-1301	40	6	the	the	DET
dti-1301	40	7	plasma	plasma	NOUN
dti-1301	40	8	membranes	membrane	NOUN
dti-1301	40	9	and	and	CCONJ
dti-1301	40	10	turn	turn	VERB
dti-1301	40	11	into	into	ADP
dti-1301	40	12	coated	coated	ADJ
dti-1301	40	13	vesicles	vesicle	NOUN
dti-1301	40	14	by	by	ADP
dti-1301	40	15	pinching	pinch	VERB
dti-1301	40	16	inward	inward	ADV
dti-1301	40	17	from	from	ADP
dti-1301	40	18	the	the	DET
dti-1301	40	19	membrane	membrane	NOUN
dti-1301	40	20	.	.	PUNCT
dti-1301	41	1	after	after	ADP
dti-1301	41	2	their	their	PRON
dti-1301	41	3	formation	formation	NOUN
dti-1301	41	4	,	,	PUNCT
dti-1301	41	5	the	the	DET
dti-1301	41	6	coated	coat	VERB
dti-1301	41	7	vesicles	vesicle	NOUN
dti-1301	41	8	lose	lose	VERB
dti-1301	41	9	the	the	DET
dti-1301	41	10	clathrin	clathrin	NOUN
dti-1301	41	11	coats	coat	NOUN
dti-1301	41	12	rapidly	rapidly	ADV
dti-1301	41	13	,	,	PUNCT
dti-1301	41	14	and	and	CCONJ
dti-1301	41	15	as	as	ADP
dti-1301	41	16	a	a	DET
dti-1301	41	17	result	result	NOUN
dti-1301	41	18	,	,	PUNCT
dti-1301	41	19	smooth	smooth	ADJ
dti-1301	41	20	membrane	membrane	NOUN
dti-1301	41	21	vesicles	vesicle	NOUN
dti-1301	41	22	and	and	CCONJ
dti-1301	41	23	tubules	tubule	NOUN
dti-1301	41	24	are	be	AUX
dti-1301	41	25	formed	form	VERB
dti-1301	41	26	(	(	PUNCT
dti-1301	41	27	morris	morris	PROPN
dti-1301	41	28	et	et	PROPN
dti-1301	41	29	al	al	PROPN
dti-1301	41	30	.	.	PROPN
dti-1301	41	31	1989	1989	NUM
dti-1301	41	32	;	;	PUNCT
dti-1301	41	33	vyas	vyas	PROPN
dti-1301	41	34	and	and	CCONJ
dti-1301	41	35	sihorkar	sihorkar	NOUN
dti-1301	41	36	,	,	PUNCT
dti-1301	41	37	2000	2000	NUM
dti-1301	41	38	)	)	PUNCT
dti-1301	41	39	.	.	PUNCT
dti-1301	42	1	these	these	DET
dti-1301	42	2	early	early	ADJ
dti-1301	42	3	endosomes	endosome	NOUN
dti-1301	42	4	,	,	PUNCT
dti-1301	42	5	which	which	PRON
dti-1301	42	6	carry	carry	VERB
dti-1301	42	7	receptors	receptor	NOUN
dti-1301	42	8	and	and	CCONJ
dti-1301	42	9	ligands	ligand	NOUN
dti-1301	42	10	,	,	PUNCT
dti-1301	42	11	subsequently	subsequently	ADV
dti-1301	42	12	participate	participate	VERB
dti-1301	42	13	in	in	ADP
dti-1301	42	14	a	a	DET
dti-1301	42	15	sequence	sequence	NOUN
dti-1301	42	16	of	of	ADP
dti-1301	42	17	intracellular	intracellular	ADJ
dti-1301	42	18	processing	processing	NOUN
dti-1301	42	19	and	and	CCONJ
dti-1301	42	20	sorting	sort	VERB
dti-1301	42	21	events	event	NOUN
dti-1301	42	22	.	.	PUNCT
dti-1301	43	1	the	the	DET
dti-1301	43	2	clathrin	clathrin	NOUN
dti-1301	43	3	-	-	PUNCT
dti-1301	43	4	independent	independent	ADJ
dti-1301	43	5	pathway	pathway	NOUN
dti-1301	43	6	,	,	PUNCT
dti-1301	43	7	on	on	ADP
dti-1301	43	8	the	the	DET
dti-1301	43	9	other	other	ADJ
dti-1301	43	10	hand	hand	NOUN
dti-1301	43	11	,	,	PUNCT
dti-1301	43	12	involves	involve	VERB
dti-1301	43	13	vesicle	vesicle	NOUN
dti-1301	43	14	formation	formation	NOUN
dti-1301	43	15	derived	derive	VERB
dti-1301	43	16	from	from	ADP
dti-1301	43	17	the	the	DET
dti-1301	43	18	invagination	invagination	NOUN
dti-1301	43	19	of	of	ADP
dti-1301	43	20	non	non	ADJ
dti-1301	43	21	-	-	ADJ
dti-1301	43	22	clathrin	clathrin	NOUN
dti-1301	43	23	-	-	PUNCT
dti-1301	43	24	coated	coat	VERB
dti-1301	43	25	plasma	plasma	NOUN
dti-1301	43	26	membrane	membrane	NOUN
dti-1301	43	27	.	.	PUNCT
dti-1301	44	1	in	in	ADP
dti-1301	44	2	general	general	ADJ
dti-1301	44	3	,	,	PUNCT
dti-1301	44	4	this	this	DET
dti-1301	44	5	type	type	NOUN
dti-1301	44	6	of	of	ADP
dti-1301	44	7	receptor	receptor	NOUN
dti-1301	44	8	-	-	PUNCT
dti-1301	44	9	mediated	mediate	VERB
dti-1301	44	10	endocytosis	endocytosis	NOUN
dti-1301	44	11	occurs	occur	VERB
dti-1301	44	12	in	in	ADP
dti-1301	44	13	receptors	receptor	NOUN
dti-1301	44	14	figure	figure	VERB
dti-1301	44	15	1	1	NUM
dti-1301	44	16	.	.	PUNCT
dti-1301	44	17	schematical	schematical	ADJ
dti-1301	44	18	illustration	illustration	NOUN
dti-1301	44	19	of	of	ADP
dti-1301	44	20	the	the	DET
dti-1301	44	21	barrier	barrier	NOUN
dti-1301	44	22	properties	property	NOUN
dti-1301	44	23	of	of	ADP
dti-1301	44	24	the	the	DET
dti-1301	44	25	intestinal	intestinal	ADJ
dti-1301	44	26	mucosa	mucosa	NOUN
dti-1301	44	27	.	.	PUNCT
dti-1301	45	1	a	a	X
dti-1301	45	2	)	)	PUNCT
dti-1301	45	3	the	the	DET
dti-1301	45	4	physical	physical	ADJ
dti-1301	45	5	barrier	barrier	NOUN
dti-1301	45	6	includes	include	VERB
dti-1301	45	7	the	the	DET
dti-1301	45	8	tight	tight	ADJ
dti-1301	45	9	junctions	junction	NOUN
dti-1301	45	10	that	that	PRON
dti-1301	45	11	limit	limit	VERB
dti-1301	45	12	paracellular	paracellular	ADJ
dti-1301	45	13	transport	transport	NOUN
dti-1301	45	14	and	and	CCONJ
dti-1301	45	15	the	the	DET
dti-1301	45	16	epithelial	epithelial	ADJ
dti-1301	45	17	cell	cell	NOUN
dti-1301	45	18	membrane	membrane	NOUN
dti-1301	45	19	that	that	PRON
dti-1301	45	20	limits	limit	VERB
dti-1301	45	21	the	the	DET
dti-1301	45	22	transcellular	transcellular	NOUN
dti-1301	45	23	transport	transport	NOUN
dti-1301	45	24	and	and	CCONJ
dti-1301	45	25	b	b	X
dti-1301	45	26	)	)	PUNCT
dti-1301	45	27	the	the	DET
dti-1301	45	28	biochemical	biochemical	ADJ
dti-1301	45	29	barrier	barrier	NOUN
dti-1301	45	30	includes	include	VERB
dti-1301	45	31	brush	brush	NOUN
dti-1301	45	32	border	border	NOUN
dti-1301	45	33	and/or	and/or	CCONJ
dti-1301	45	34	intracellular	intracellular	ADJ
dti-1301	45	35	metabolism	metabolism	NOUN
dti-1301	45	36	and	and	CCONJ
dti-1301	45	37	apical	apical	ADJ
dti-1301	45	38	polarized	polarize	VERB
dti-1301	45	39	effl	effl	PROPN
dti-1301	45	40	ux	ux	PROPN
dti-1301	45	41	(	(	PUNCT
dti-1301	45	42	with	with	ADP
dti-1301	45	43	permission	permission	NOUN
dti-1301	45	44	from	from	ADP
dti-1301	45	45	pauletti	pauletti	NOUN
dti-1301	45	46	et	et	PROPN
dti-1301	45	47	al	al	PROPN
dti-1301	45	48	.	.	PROPN
dti-1301	45	49	1996	1996	NUM
dti-1301	45	50	)	)	PUNCT
dti-1301	45	51	.	.	PUNCT
dti-1301	46	1	drug	drug	NOUN
dti-1301	46	2	target	target	NOUN
dti-1301	46	3	insights	insight	NOUN
dti-1301	46	4	2007	2007	NUM
dti-1301	46	5	:	:	PUNCT
dti-1301	46	6	2	2	NUM
dti-1301	46	7	73	73	NUM
dti-1301	46	8	targeted	target	VERB
dti-1301	46	9	oral	oral	ADJ
dti-1301	46	10	drug	drug	NOUN
dti-1301	46	11	delivery	delivery	NOUN
dti-1301	46	12	with	with	ADP
dti-1301	46	13	a	a	DET
dti-1301	46	14	low	low	ADJ
dti-1301	46	15	population	population	NOUN
dti-1301	46	16	and	and	CCONJ
dti-1301	46	17	a	a	DET
dti-1301	46	18	slow	slow	ADJ
dti-1301	46	19	rate	rate	NOUN
dti-1301	46	20	of	of	ADP
dti-1301	46	21	internalization	internalization	NOUN
dti-1301	46	22	,	,	PUNCT
dti-1301	46	23	when	when	SCONJ
dti-1301	46	24	compared	compare	VERB
dti-1301	46	25	to	to	ADP
dti-1301	46	26	that	that	PRON
dti-1301	46	27	of	of	ADP
dti-1301	46	28	the	the	DET
dti-1301	46	29	clathrindependent	clathrindependent	NOUN
dti-1301	46	30	pathway	pathway	NOUN
dti-1301	46	31	.	.	PUNCT
dti-1301	47	1	the	the	DET
dti-1301	47	2	exact	exact	ADJ
dti-1301	47	3	internalization	internalization	NOUN
dti-1301	47	4	mechanism	mechanism	NOUN
dti-1301	47	5	of	of	ADP
dti-1301	47	6	this	this	DET
dti-1301	47	7	pathway	pathway	NOUN
dti-1301	47	8	is	be	AUX
dti-1301	47	9	still	still	ADV
dti-1301	47	10	largely	largely	ADV
dti-1301	47	11	unknown	unknown	ADJ
dti-1301	47	12	(	(	PUNCT
dti-1301	47	13	shen	shen	PROPN
dti-1301	47	14	et	et	PROPN
dti-1301	47	15	al	al	PROPN
dti-1301	47	16	.	.	PROPN
dti-1301	47	17	1992	1992	NUM
dti-1301	47	18	)	)	PUNCT
dti-1301	47	19	.	.	PUNCT
dti-1301	48	1	following	follow	VERB
dti-1301	48	2	receptor	receptor	NOUN
dti-1301	48	3	-	-	PUNCT
dti-1301	48	4	mediated	mediate	VERB
dti-1301	48	5	endocytosis	endocytosis	NOUN
dti-1301	48	6	process	process	NOUN
dti-1301	48	7	,	,	PUNCT
dti-1301	48	8	the	the	DET
dti-1301	48	9	endocytosed	endocytose	VERB
dti-1301	48	10	material	material	NOUN
dti-1301	48	11	may	may	AUX
dti-1301	48	12	be	be	AUX
dti-1301	48	13	processed	process	VERB
dti-1301	48	14	in	in	ADP
dti-1301	48	15	one	one	NUM
dti-1301	48	16	of	of	ADP
dti-1301	48	17	four	four	NUM
dti-1301	48	18	ways	way	NOUN
dti-1301	48	19	.	.	PUNCT
dti-1301	49	1	most	most	ADJ
dti-1301	49	2	ligands	ligand	NOUN
dti-1301	49	3	are	be	AUX
dti-1301	49	4	dissociated	dissociate	VERB
dti-1301	49	5	from	from	ADP
dti-1301	49	6	their	their	PRON
dti-1301	49	7	receptors	receptor	NOUN
dti-1301	49	8	by	by	ADP
dti-1301	49	9	the	the	DET
dti-1301	49	10	low	low	ADJ
dti-1301	49	11	ph	ph	NOUN
dti-1301	49	12	(	(	PUNCT
dti-1301	49	13	i.e.	i.e.	X
dti-1301	49	14	<	<	X
dti-1301	49	15	5.5	5.5	NUM
dti-1301	49	16	)	)	PUNCT
dti-1301	49	17	encountered	encounter	VERB
dti-1301	49	18	within	within	ADP
dti-1301	49	19	the	the	DET
dti-1301	49	20	endosomes	endosome	NOUN
dti-1301	49	21	or	or	CCONJ
dti-1301	49	22	the	the	DET
dti-1301	49	23	receptosomes	receptosome	NOUN
dti-1301	49	24	or	or	CCONJ
dti-1301	49	25	the	the	DET
dti-1301	49	26	compartment	compartment	NOUN
dti-1301	49	27	for	for	ADP
dti-1301	49	28	uncoupling	uncoupling	NOUN
dti-1301	49	29	of	of	ADP
dti-1301	49	30	receptors	receptor	NOUN
dti-1301	49	31	or	or	CCONJ
dti-1301	49	32	ligands	ligand	NOUN
dti-1301	49	33	(	(	PUNCT
dti-1301	49	34	curl	curl	NOUN
dti-1301	49	35	)	)	PUNCT
dti-1301	49	36	(	(	PUNCT
dti-1301	49	37	geuze	geuze	NOUN
dti-1301	49	38	et	et	PROPN
dti-1301	49	39	al	al	PROPN
dti-1301	49	40	.	.	PROPN
dti-1301	49	41	1983	1983	NUM
dti-1301	49	42	)	)	PUNCT
dti-1301	49	43	.	.	PUNCT
dti-1301	50	1	the	the	DET
dti-1301	50	2	receptors	receptor	NOUN
dti-1301	50	3	may	may	AUX
dti-1301	50	4	either	either	CCONJ
dti-1301	50	5	be	be	AUX
dti-1301	50	6	recycled	recycle	VERB
dti-1301	50	7	to	to	ADP
dti-1301	50	8	the	the	DET
dti-1301	50	9	cell	cell	NOUN
dti-1301	50	10	surface	surface	NOUN
dti-1301	50	11	or	or	CCONJ
dti-1301	50	12	degraded	degrade	VERB
dti-1301	50	13	,	,	PUNCT
dti-1301	50	14	while	while	SCONJ
dti-1301	50	15	the	the	DET
dti-1301	50	16	ligand	ligand	NOUN
dti-1301	50	17	is	be	AUX
dti-1301	50	18	routed	route	VERB
dti-1301	50	19	to	to	ADP
dti-1301	50	20	the	the	DET
dti-1301	50	21	lysosomes	lysosome	NOUN
dti-1301	50	22	for	for	ADP
dti-1301	50	23	degradation	degradation	NOUN
dti-1301	50	24	(	(	PUNCT
dti-1301	50	25	mostov	mostov	NOUN
dti-1301	50	26	et	et	PROPN
dti-1301	50	27	al	al	PROPN
dti-1301	50	28	.	.	PROPN
dti-1301	50	29	1985	1985	NUM
dti-1301	50	30	)	)	PUNCT
dti-1301	50	31	.	.	PUNCT
dti-1301	51	1	alternatively	alternatively	ADV
dti-1301	51	2	,	,	PUNCT
dti-1301	51	3	the	the	DET
dti-1301	51	4	binding	binding	NOUN
dti-1301	51	5	between	between	ADP
dti-1301	51	6	the	the	DET
dti-1301	51	7	receptor	receptor	NOUN
dti-1301	51	8	and	and	CCONJ
dti-1301	51	9	ligand	ligand	NOUN
dti-1301	51	10	may	may	AUX
dti-1301	51	11	be	be	AUX
dti-1301	51	12	unaffected	unaffected	ADJ
dti-1301	51	13	by	by	ADP
dti-1301	51	14	acidifi	acidifi	NOUN
dti-1301	51	15	cation	cation	NOUN
dti-1301	51	16	and	and	CCONJ
dti-1301	51	17	the	the	DET
dti-1301	51	18	receptor	receptor	NOUN
dti-1301	51	19	-	-	PUNCT
dti-1301	51	20	ligand	ligand	NOUN
dti-1301	51	21	complexes	complex	NOUN
dti-1301	51	22	are	be	AUX
dti-1301	51	23	directly	directly	ADV
dti-1301	51	24	sorted	sort	VERB
dti-1301	51	25	to	to	ADP
dti-1301	51	26	lysosomes	lysosome	NOUN
dti-1301	51	27	for	for	ADP
dti-1301	51	28	degradation	degradation	NOUN
dti-1301	51	29	e.g.	e.g.	ADV
dti-1301	51	30	insulin	insulin	NOUN
dti-1301	51	31	receptor	receptor	NOUN
dti-1301	51	32	(	(	PUNCT
dti-1301	51	33	féger	féger	NOUN
dti-1301	51	34	et	et	PROPN
dti-1301	51	35	al	al	PROPN
dti-1301	51	36	.	.	PROPN
dti-1301	51	37	1994	1994	NUM
dti-1301	51	38	)	)	PUNCT
dti-1301	51	39	.	.	PUNCT
dti-1301	52	1	the	the	DET
dti-1301	52	2	internalization	internalization	NOUN
dti-1301	52	3	of	of	ADP
dti-1301	52	4	transferrin	transferrin	NOUN
dti-1301	52	5	-	-	PUNCT
dti-1301	52	6	bound	bind	VERB
dti-1301	52	7	iron	iron	NOUN
dti-1301	52	8	represents	represent	VERB
dti-1301	52	9	a	a	DET
dti-1301	52	10	third	third	ADJ
dti-1301	52	11	process	process	NOUN
dti-1301	52	12	,	,	PUNCT
dti-1301	52	13	in	in	ADP
dti-1301	52	14	which	which	PRON
dti-1301	52	15	the	the	DET
dti-1301	52	16	iron	iron	NOUN
dti-1301	52	17	dissociates	dissociate	NOUN
dti-1301	52	18	from	from	ADP
dti-1301	52	19	the	the	DET
dti-1301	52	20	transferrin	transferrin	NOUN
dti-1301	52	21	,	,	PUNCT
dti-1301	52	22	which	which	PRON
dti-1301	52	23	is	be	AUX
dti-1301	52	24	then	then	ADV
dti-1301	52	25	returned	return	VERB
dti-1301	52	26	to	to	ADP
dti-1301	52	27	the	the	DET
dti-1301	52	28	cell	cell	NOUN
dti-1301	52	29	surface	surface	NOUN
dti-1301	52	30	(	(	PUNCT
dti-1301	52	31	russeljones	russeljone	NOUN
dti-1301	52	32	,	,	PUNCT
dti-1301	52	33	2001	2001	NUM
dti-1301	52	34	)	)	PUNCT
dti-1301	52	35	.	.	PUNCT
dti-1301	53	1	the	the	DET
dti-1301	53	2	fourth	fourth	ADJ
dti-1301	53	3	case	case	NOUN
dti-1301	53	4	is	be	AUX
dti-1301	53	5	characteristic	characteristic	ADJ
dti-1301	53	6	of	of	ADP
dti-1301	53	7	epithelial	epithelial	ADJ
dti-1301	53	8	and	and	CCONJ
dti-1301	53	9	enterocytic	enterocytic	ADJ
dti-1301	53	10	cells	cell	NOUN
dti-1301	53	11	,	,	PUNCT
dti-1301	53	12	and	and	CCONJ
dti-1301	53	13	results	result	NOUN
dti-1301	53	14	in	in	ADP
dti-1301	53	15	the	the	DET
dti-1301	53	16	endocytosed	endocytose	VERB
dti-1301	53	17	material	material	NOUN
dti-1301	53	18	being	being	AUX
dti-1301	53	19	transcytosed	transcytose	VERB
dti-1301	53	20	across	across	ADP
dti-1301	53	21	the	the	DET
dti-1301	53	22	cell	cell	NOUN
dti-1301	53	23	.	.	PUNCT
dti-1301	54	1	in	in	ADP
dti-1301	54	2	this	this	DET
dti-1301	54	3	process	process	NOUN
dti-1301	54	4	,	,	PUNCT
dti-1301	54	5	the	the	DET
dti-1301	54	6	ligands	ligand	NOUN
dti-1301	54	7	such	such	ADJ
dti-1301	54	8	as	as	SCONJ
dti-1301	54	9	thyroglobulin	thyroglobulin	PROPN
dti-1301	54	10	bind	bind	VERB
dti-1301	54	11	to	to	ADP
dti-1301	54	12	their	their	PRON
dti-1301	54	13	receptors	receptor	NOUN
dti-1301	54	14	on	on	ADP
dti-1301	54	15	either	either	CCONJ
dti-1301	54	16	the	the	DET
dti-1301	54	17	apical	apical	ADJ
dti-1301	54	18	or	or	CCONJ
dti-1301	54	19	basolateral	basolateral	ADJ
dti-1301	54	20	membrane	membrane	NOUN
dti-1301	54	21	.	.	PUNCT
dti-1301	55	1	the	the	DET
dti-1301	55	2	complex	complex	NOUN
dti-1301	55	3	is	be	AUX
dti-1301	55	4	then	then	ADV
dti-1301	55	5	endocytosed	endocytose	VERB
dti-1301	55	6	and	and	CCONJ
dti-1301	55	7	transported	transport	VERB
dti-1301	55	8	to	to	ADP
dti-1301	55	9	endosomes	endosome	NOUN
dti-1301	55	10	via	via	ADP
dti-1301	55	11	coated	coated	ADJ
dti-1301	55	12	vesicles	vesicle	NOUN
dti-1301	55	13	.	.	PUNCT
dti-1301	56	1	the	the	DET
dti-1301	56	2	endosomal	endosomal	ADJ
dti-1301	56	3	material	material	NOUN
dti-1301	56	4	is	be	AUX
dti-1301	56	5	uncoupled	uncoupled	ADJ
dti-1301	56	6	from	from	ADP
dti-1301	56	7	its	its	PRON
dti-1301	56	8	receptor	receptor	NOUN
dti-1301	56	9	and	and	CCONJ
dti-1301	56	10	then	then	ADV
dti-1301	56	11	transported	transport	VERB
dti-1301	56	12	across	across	ADP
dti-1301	56	13	the	the	DET
dti-1301	56	14	cell	cell	NOUN
dti-1301	56	15	in	in	ADP
dti-1301	56	16	an	an	PRON
dti-1301	56	17	as	as	ADV
dti-1301	56	18	yet	yet	ADV
dti-1301	56	19	to	to	PART
dti-1301	56	20	be	be	AUX
dti-1301	56	21	identifi	identifi	PROPN
dti-1301	56	22	ed	ed	NOUN
dti-1301	56	23	membrane	membrane	NOUN
dti-1301	56	24	vesicle	vesicle	NOUN
dti-1301	56	25	(	(	PUNCT
dti-1301	56	26	simons	simon	NOUN
dti-1301	56	27	et	et	PROPN
dti-1301	56	28	al	al	PROPN
dti-1301	56	29	.	.	PROPN
dti-1301	56	30	1985	1985	NUM
dti-1301	56	31	)	)	PUNCT
dti-1301	56	32	.	.	PUNCT
dti-1301	57	1	the	the	DET
dti-1301	57	2	use	use	NOUN
dti-1301	57	3	of	of	ADP
dti-1301	57	4	receptor	receptor	NOUN
dti-1301	57	5	-	-	PUNCT
dti-1301	57	6	mediated	mediate	VERB
dti-1301	57	7	endocytosis	endocytosis	NOUN
dti-1301	57	8	in	in	ADP
dti-1301	57	9	the	the	DET
dti-1301	57	10	gut	gut	NOUN
dti-1301	57	11	is	be	AUX
dti-1301	57	12	very	very	ADV
dti-1301	57	13	important	important	ADJ
dti-1301	57	14	for	for	ADP
dti-1301	57	15	oral	oral	ADJ
dti-1301	57	16	drug	drug	NOUN
dti-1301	57	17	delivery	delivery	NOUN
dti-1301	57	18	because	because	SCONJ
dti-1301	57	19	it	it	PRON
dti-1301	57	20	can	can	AUX
dti-1301	57	21	be	be	AUX
dti-1301	57	22	used	use	VERB
dti-1301	57	23	to	to	PART
dti-1301	57	24	delay	delay	VERB
dti-1301	57	25	intestinal	intestinal	ADJ
dti-1301	57	26	transit	transit	NOUN
dti-1301	57	27	of	of	ADP
dti-1301	57	28	drugs	drug	NOUN
dti-1301	57	29	(	(	PUNCT
dti-1301	57	30	kilpatrick	kilpatrick	PROPN
dti-1301	57	31	et	et	PROPN
dti-1301	57	32	al	al	PROPN
dti-1301	57	33	.	.	PROPN
dti-1301	57	34	1985	1985	NUM
dti-1301	57	35	;	;	PUNCT
dti-1301	57	36	king	king	NOUN
dti-1301	57	37	et	et	PROPN
dti-1301	57	38	al	al	PROPN
dti-1301	57	39	.	.	PROPN
dti-1301	57	40	1986	1986	NUM
dti-1301	57	41	;	;	PUNCT
dti-1301	57	42	woodley	woodley	NOUN
dti-1301	57	43	and	and	CCONJ
dti-1301	57	44	naisbet	naisbet	NOUN
dti-1301	57	45	,	,	PUNCT
dti-1301	57	46	1988	1988	NUM
dti-1301	57	47	;	;	PUNCT
dti-1301	57	48	lehr	lehr	NOUN
dti-1301	57	49	et	et	PROPN
dti-1301	57	50	al	al	PROPN
dti-1301	57	51	.	.	PROPN
dti-1301	57	52	1992	1992	NUM
dti-1301	57	53	)	)	PUNCT
dti-1301	57	54	,	,	PUNCT
dti-1301	57	55	to	to	PART
dti-1301	57	56	target	target	VERB
dti-1301	57	57	drugs	drug	NOUN
dti-1301	57	58	to	to	ADP
dti-1301	57	59	the	the	DET
dti-1301	57	60	intestinal	intestinal	ADJ
dti-1301	57	61	epithelial	epithelial	ADJ
dti-1301	57	62	cells	cell	NOUN
dti-1301	57	63	(	(	PUNCT
dti-1301	57	64	russel	russel	NOUN
dti-1301	57	65	-	-	PUNCT
dti-1301	57	66	jones	jones	PROPN
dti-1301	57	67	,	,	PUNCT
dti-1301	57	68	2001	2001	NUM
dti-1301	57	69	)	)	PUNCT
dti-1301	57	70	and	and	CCONJ
dti-1301	57	71	for	for	ADP
dti-1301	57	72	systemic	systemic	ADJ
dti-1301	57	73	drug	drug	NOUN
dti-1301	57	74	delivery	delivery	NOUN
dti-1301	57	75	(	(	PUNCT
dti-1301	57	76	de	de	X
dti-1301	57	77	aizpurua	aizpurua	PROPN
dti-1301	57	78	and	and	CCONJ
dti-1301	57	79	russel	russel	PROPN
dti-1301	57	80	-	-	PUNCT
dti-1301	57	81	jones	jones	PROPN
dti-1301	57	82	,	,	PUNCT
dti-1301	57	83	1987	1987	NUM
dti-1301	57	84	;	;	PUNCT
dti-1301	57	85	pusztai	pusztai	NOUN
dti-1301	57	86	,	,	PUNCT
dti-1301	57	87	1989	1989	NUM
dti-1301	57	88	;	;	PUNCT
dti-1301	57	89	lindner	lindner	PROPN
dti-1301	57	90	et	et	PROPN
dti-1301	57	91	al	al	PROPN
dti-1301	57	92	.	.	PROPN
dti-1301	57	93	1994	1994	NUM
dti-1301	57	94	)	)	PUNCT
dti-1301	57	95	.	.	PUNCT
dti-1301	58	1	signifi	signifi	PROPN
dti-1301	58	2	ca	can	AUX
dti-1301	58	3	nt	not	PART
dti-1301	58	4	developments	development	NOUN
dti-1301	58	5	in	in	ADP
dti-1301	58	6	the	the	DET
dti-1301	58	7	oral	oral	ADJ
dti-1301	58	8	delivery	delivery	NOUN
dti-1301	58	9	of	of	ADP
dti-1301	58	10	peptides	peptide	NOUN
dti-1301	58	11	and	and	CCONJ
dti-1301	58	12	proteins	protein	NOUN
dti-1301	58	13	have	have	AUX
dti-1301	58	14	been	be	AUX
dti-1301	58	15	conducted	conduct	VERB
dti-1301	58	16	involving	involve	VERB
dti-1301	58	17	receptor	receptor	NOUN
dti-1301	58	18	-	-	PUNCT
dti-1301	58	19	mediated	mediate	VERB
dti-1301	58	20	endocytosis	endocytosis	NOUN
dti-1301	58	21	process	process	NOUN
dti-1301	58	22	in	in	ADP
dti-1301	58	23	the	the	DET
dti-1301	58	24	vitamin	vitamin	NOUN
dti-1301	58	25	b12	b12	NOUN
dti-1301	58	26	uptake	uptake	ADJ
dti-1301	58	27	system	system	NOUN
dti-1301	58	28	(	(	PUNCT
dti-1301	58	29	de	de	X
dti-1301	58	30	aizpurua	aizpurua	PROPN
dti-1301	58	31	et	et	PROPN
dti-1301	58	32	al	al	PROPN
dti-1301	58	33	.	.	PROPN
dti-1301	58	34	1986	1986	NUM
dti-1301	58	35	;	;	PUNCT
dti-1301	58	36	russel	russel	PROPN
dti-1301	58	37	-	-	PUNCT
dti-1301	58	38	jones	jones	PROPN
dti-1301	58	39	and	and	CCONJ
dti-1301	58	40	de	de	X
dti-1301	58	41	aizpurua	aizpurua	NOUN
dti-1301	58	42	,	,	PUNCT
dti-1301	58	43	1988	1988	NUM
dti-1301	58	44	;	;	PUNCT
dti-1301	58	45	habberfi	habberfi	PROPN
dti-1301	58	46	eld	eld	PROPN
dti-1301	58	47	et	et	PROPN
dti-1301	58	48	al	al	PROPN
dti-1301	58	49	.	.	PROPN
dti-1301	58	50	1996	1996	NUM
dti-1301	58	51	;	;	PUNCT
dti-1301	58	52	russeljones	russeljone	NOUN
dti-1301	58	53	,	,	PUNCT
dti-1301	58	54	2001	2001	NUM
dti-1301	58	55	)	)	PUNCT
dti-1301	58	56	,	,	PUNCT
dti-1301	58	57	folate	folate	NOUN
dti-1301	58	58	absorption	absorption	NOUN
dti-1301	58	59	(	(	PUNCT
dti-1301	58	60	ward	ward	NOUN
dti-1301	58	61	et	et	PROPN
dti-1301	58	62	al	al	PROPN
dti-1301	58	63	.	.	PROPN
dti-1301	58	64	2000	2000	NUM
dti-1301	58	65	;	;	PUNCT
dti-1301	58	66	ni	ni	PROPN
dti-1301	58	67	et	et	PROPN
dti-1301	58	68	al	al	PROPN
dti-1301	58	69	.	.	PROPN
dti-1301	58	70	2002	2002	NUM
dti-1301	58	71	;	;	PUNCT
dti-1301	58	72	lu	lu	PROPN
dti-1301	58	73	,	,	PUNCT
dti-1301	58	74	2002	2002	NUM
dti-1301	58	75	)	)	PUNCT
dti-1301	58	76	and	and	CCONJ
dti-1301	58	77	also	also	ADV
dti-1301	58	78	system	system	NOUN
dti-1301	58	79	in	in	ADP
dti-1301	58	80	which	which	PRON
dti-1301	58	81	transferrin	transferrin	NOUN
dti-1301	58	82	-	-	PUNCT
dti-1301	58	83	receptors	receptor	NOUN
dti-1301	58	84	are	be	AUX
dti-1301	58	85	activated	activate	VERB
dti-1301	58	86	(	(	PUNCT
dti-1301	58	87	qian	qian	PROPN
dti-1301	58	88	et	et	PROPN
dti-1301	58	89	al	al	PROPN
dti-1301	58	90	.	.	PROPN
dti-1301	58	91	2002	2002	NUM
dti-1301	58	92	;	;	PUNCT
dti-1301	58	93	kovar	kovar	PROPN
dti-1301	58	94	et	et	PROPN
dti-1301	58	95	al	al	PROPN
dti-1301	58	96	.	.	PROPN
dti-1301	58	97	2002	2002	NUM
dti-1301	58	98	;	;	PUNCT
dti-1301	58	99	kursa	kursa	PROPN
dti-1301	58	100	et	et	PROPN
dti-1301	58	101	al	al	PROPN
dti-1301	58	102	.	.	PROPN
dti-1301	58	103	2003	2003	NUM
dti-1301	58	104	)	)	PUNCT
dti-1301	58	105	.	.	PUNCT
dti-1301	59	1	vitamin	vitamin	NOUN
dti-1301	59	2	b12	b12	NOUN
dti-1301	59	3	(	(	PUNCT
dti-1301	59	4	cyanocobalamine	cyanocobalamine	NOUN
dti-1301	59	5	)	)	PUNCT
dti-1301	59	6	vitamin	vitamin	NOUN
dti-1301	59	7	b12	b12	NOUN
dti-1301	59	8	is	be	AUX
dti-1301	59	9	a	a	DET
dti-1301	59	10	much	much	ADV
dti-1301	59	11	larger	large	ADJ
dti-1301	59	12	molecule	molecule	NOUN
dti-1301	59	13	than	than	ADP
dti-1301	59	14	other	other	ADJ
dti-1301	59	15	vitamins	vitamin	NOUN
dti-1301	59	16	and	and	CCONJ
dti-1301	59	17	therefore	therefore	ADV
dti-1301	59	18	can	can	AUX
dti-1301	59	19	not	not	PART
dti-1301	59	20	enter	enter	VERB
dti-1301	59	21	the	the	DET
dti-1301	59	22	body	body	NOUN
dti-1301	59	23	through	through	ADP
dti-1301	59	24	simple	simple	ADJ
dti-1301	59	25	diffusion	diffusion	NOUN
dti-1301	59	26	,	,	PUNCT
dti-1301	59	27	facililated	facililate	VERB
dti-1301	59	28	diffusion	diffusion	NOUN
dti-1301	59	29	or	or	CCONJ
dti-1301	59	30	active	active	ADJ
dti-1301	59	31	transport	transport	NOUN
dti-1301	59	32	(	(	PUNCT
dti-1301	59	33	russel	russel	PROPN
dti-1301	59	34	-	-	PUNCT
dti-1301	59	35	jones	jones	PROPN
dti-1301	59	36	,	,	PUNCT
dti-1301	59	37	2001	2001	NUM
dti-1301	59	38	)	)	PUNCT
dti-1301	59	39	.	.	PUNCT
dti-1301	60	1	during	during	ADP
dti-1301	60	2	the	the	DET
dti-1301	60	3	absorption	absorption	NOUN
dti-1301	60	4	of	of	ADP
dti-1301	60	5	vitamin	vitamin	NOUN
dti-1301	60	6	b12	b12	NOUN
dti-1301	60	7	,	,	PUNCT
dti-1301	60	8	intrinsic	intrinsic	ADJ
dti-1301	60	9	factor	factor	NOUN
dti-1301	60	10	(	(	PUNCT
dti-1301	60	11	if	if	SCONJ
dti-1301	60	12	)	)	PUNCT
dti-1301	60	13	produced	produce	VERB
dti-1301	60	14	in	in	ADP
dti-1301	60	15	the	the	DET
dti-1301	60	16	stomach	stomach	NOUN
dti-1301	60	17	binds	bind	VERB
dti-1301	60	18	to	to	PART
dti-1301	60	19	vitamin	vitamin	NOUN
dti-1301	60	20	b12	b12	NOUN
dti-1301	60	21	forming	form	VERB
dti-1301	60	22	a	a	DET
dti-1301	60	23	complex	complex	NOUN
dti-1301	60	24	which	which	PRON
dti-1301	60	25	passes	pass	VERB
dti-1301	60	26	down	down	ADP
dti-1301	60	27	the	the	DET
dti-1301	60	28	small	small	ADJ
dti-1301	60	29	intestine	intestine	NOUN
dti-1301	60	30	until	until	SCONJ
dti-1301	60	31	it	it	PRON
dti-1301	60	32	reaches	reach	VERB
dti-1301	60	33	the	the	DET
dti-1301	60	34	ileum	ileum	NOUN
dti-1301	60	35	.	.	PUNCT
dti-1301	61	1	here	here	ADV
dti-1301	61	2	the	the	DET
dti-1301	61	3	complex	complex	NOUN
dti-1301	61	4	binds	bind	VERB
dti-1301	61	5	to	to	ADP
dti-1301	61	6	a	a	DET
dti-1301	61	7	specifi	specifi	PROPN
dti-1301	61	8	c	c	PROPN
dti-1301	62	1	if	if	SCONJ
dti-1301	62	2	receptor	receptor	NOUN
dti-1301	62	3	(	(	PUNCT
dti-1301	62	4	ifr	ifr	PROPN
dti-1301	62	5	)	)	PUNCT
dti-1301	62	6	located	locate	VERB
dti-1301	62	7	on	on	ADP
dti-1301	62	8	the	the	DET
dti-1301	62	9	apical	apical	ADJ
dti-1301	62	10	membrane	membrane	NOUN
dti-1301	62	11	of	of	ADP
dti-1301	62	12	the	the	DET
dti-1301	62	13	villous	villous	ADJ
dti-1301	62	14	enterocyte	enterocyte	NOUN
dti-1301	62	15	depending	depend	VERB
dti-1301	62	16	on	on	ADP
dti-1301	62	17	the	the	DET
dti-1301	62	18	concentration	concentration	NOUN
dti-1301	62	19	of	of	ADP
dti-1301	62	20	calcium	calcium	NOUN
dti-1301	62	21	ions	ion	NOUN
dti-1301	62	22	.	.	PUNCT
dti-1301	63	1	the	the	DET
dti-1301	63	2	complex	complex	NOUN
dti-1301	63	3	is	be	AUX
dti-1301	63	4	then	then	ADV
dti-1301	63	5	internalized	internalize	VERB
dti-1301	63	6	by	by	ADP
dti-1301	63	7	the	the	DET
dti-1301	63	8	enterocyte	enterocyte	NOUN
dti-1301	63	9	via	via	ADP
dti-1301	63	10	receptor	receptor	NOUN
dti-1301	63	11	-	-	PUNCT
dti-1301	63	12	mediated	mediate	VERB
dti-1301	63	13	endocytosis	endocytosis	NOUN
dti-1301	63	14	.	.	PUNCT
dti-1301	64	1	once	once	ADV
dti-1301	64	2	inside	inside	ADP
dti-1301	64	3	the	the	DET
dti-1301	64	4	cell	cell	NOUN
dti-1301	64	5	,	,	PUNCT
dti-1301	64	6	the	the	DET
dti-1301	64	7	vitamin	vitamin	NOUN
dti-1301	64	8	b12	b12	NOUN
dti-1301	64	9	is	be	AUX
dti-1301	64	10	released	release	VERB
dti-1301	64	11	from	from	ADP
dti-1301	64	12	if	if	SCONJ
dti-1301	64	13	following	follow	VERB
dti-1301	64	14	the	the	DET
dti-1301	64	15	action	action	NOUN
dti-1301	64	16	of	of	ADP
dti-1301	64	17	cathepsin	cathepsin	ADJ
dti-1301	64	18	l	l	NOUN
dti-1301	64	19	on	on	ADP
dti-1301	64	20	if	if	SCONJ
dti-1301	64	21	(	(	PUNCT
dti-1301	64	22	fyfe	fyfe	ADP
dti-1301	64	23	et	et	PROPN
dti-1301	64	24	al	al	PROPN
dti-1301	64	25	.	.	PROPN
dti-1301	64	26	1991	1991	NUM
dti-1301	64	27	;	;	PUNCT
dti-1301	64	28	schohn	schohn	NOUN
dti-1301	64	29	et	et	PROPN
dti-1301	64	30	al	al	PROPN
dti-1301	64	31	.	.	PROPN
dti-1301	64	32	1991	1991	NUM
dti-1301	64	33	;	;	PUNCT
dti-1301	64	34	guéant	guéant	NOUN
dti-1301	64	35	et	et	PROPN
dti-1301	64	36	al	al	PROPN
dti-1301	64	37	.	.	PROPN
dti-1301	64	38	1992	1992	NUM
dti-1301	64	39	)	)	PUNCT
dti-1301	64	40	.	.	PUNCT
dti-1301	65	1	research	research	NOUN
dti-1301	65	2	has	have	AUX
dti-1301	65	3	demonstrated	demonstrate	VERB
dti-1301	65	4	that	that	SCONJ
dti-1301	65	5	it	it	PRON
dti-1301	65	6	is	be	AUX
dti-1301	65	7	possible	possible	ADJ
dti-1301	65	8	to	to	PART
dti-1301	65	9	link	link	VERB
dti-1301	65	10	chemically	chemically	ADV
dti-1301	65	11	peptides	peptide	NOUN
dti-1301	65	12	such	such	ADJ
dti-1301	65	13	as	as	ADP
dti-1301	65	14	luteinizing	luteinize	VERB
dti-1301	65	15	hormone	hormone	NOUN
dti-1301	65	16	-	-	PUNCT
dti-1301	65	17	releasing	release	VERB
dti-1301	65	18	hormone	hormone	NOUN
dti-1301	65	19	(	(	PUNCT
dti-1301	65	20	lhrh	lhrh	PROPN
dti-1301	65	21	)	)	PUNCT
dti-1301	65	22	,	,	PUNCT
dti-1301	65	23	and	and	CCONJ
dti-1301	65	24	protein	protein	NOUN
dti-1301	65	25	such	such	ADJ
dti-1301	65	26	as	as	ADP
dti-1301	65	27	erythropoietin	erythropoietin	NOUN
dti-1301	65	28	(	(	PUNCT
dti-1301	65	29	epo	epo	PROPN
dti-1301	65	30	)	)	PUNCT
dti-1301	65	31	,	,	PUNCT
dti-1301	65	32	granulocyte	granulocyte	ADJ
dti-1301	65	33	-	-	PUNCT
dti-1301	65	34	colony	colony	NOUN
dti-1301	65	35	stimulating	stimulate	VERB
dti-1301	65	36	factor	factor	NOUN
dti-1301	65	37	(	(	PUNCT
dti-1301	65	38	g	g	NOUN
dti-1301	65	39	-	-	PUNCT
dti-1301	65	40	csf	csf	NOUN
dti-1301	65	41	)	)	PUNCT
dti-1301	65	42	or	or	CCONJ
dti-1301	65	43	interferon	interferon	ADJ
dti-1301	65	44	-	-	PUNCT
dti-1301	65	45	α	α	NOUN
dti-1301	65	46	to	to	PART
dti-1301	65	47	vitamin	vitamin	VERB
dti-1301	65	48	b12	b12	NOUN
dti-1301	65	49	in	in	ADP
dti-1301	65	50	a	a	DET
dti-1301	65	51	way	way	NOUN
dti-1301	65	52	which	which	PRON
dti-1301	65	53	is	be	AUX
dti-1301	65	54	capable	capable	ADJ
dti-1301	65	55	of	of	ADP
dti-1301	65	56	shuttling	shuttle	VERB
dti-1301	65	57	these	these	DET
dti-1301	65	58	molecules	molecule	NOUN
dti-1301	65	59	across	across	ADP
dti-1301	65	60	the	the	DET
dti-1301	65	61	intestinal	intestinal	ADJ
dti-1301	65	62	epithelia	epithelium	NOUN
dti-1301	65	63	without	without	ADP
dti-1301	65	64	interfering	interfere	VERB
dti-1301	65	65	with	with	ADP
dti-1301	65	66	the	the	DET
dti-1301	65	67	ability	ability	NOUN
dti-1301	65	68	of	of	ADP
dti-1301	65	69	vitamin	vitamin	NOUN
dti-1301	65	70	b12	b12	NOUN
dti-1301	65	71	to	to	PART
dti-1301	65	72	bind	bind	VERB
dti-1301	65	73	to	to	ADP
dti-1301	65	74	if	if	SCONJ
dti-1301	65	75	(	(	PUNCT
dti-1301	65	76	de	de	X
dti-1301	65	77	aizpurua	aizpurua	PROPN
dti-1301	65	78	et	et	PROPN
dti-1301	65	79	al	al	PROPN
dti-1301	65	80	.	.	PROPN
dti-1301	65	81	1986	1986	NUM
dti-1301	65	82	;	;	PUNCT
dti-1301	65	83	russel	russel	PROPN
dti-1301	65	84	-	-	PUNCT
dti-1301	65	85	jones	jones	PROPN
dti-1301	65	86	and	and	CCONJ
dti-1301	65	87	de	de	X
dti-1301	65	88	aizpurua	aizpurua	NOUN
dti-1301	65	89	,	,	PUNCT
dti-1301	65	90	1988	1988	NUM
dti-1301	65	91	;	;	PUNCT
dti-1301	65	92	russel	russel	PROPN
dti-1301	65	93	-	-	PUNCT
dti-1301	65	94	jones	jones	PROPN
dti-1301	65	95	,	,	PUNCT
dti-1301	65	96	1995	1995	NUM
dti-1301	65	97	;	;	PUNCT
dti-1301	65	98	habberfi	habberfi	PROPN
dti-1301	65	99	eld	eld	PROPN
dti-1301	65	100	et	et	PROPN
dti-1301	65	101	al	al	PROPN
dti-1301	65	102	.	.	PROPN
dti-1301	65	103	1996	1996	NUM
dti-1301	65	104	)	)	PUNCT
dti-1301	65	105	.	.	PUNCT
dti-1301	66	1	vitamin	vitamin	NOUN
dti-1301	66	2	b12	b12	NOUN
dti-1301	66	3	conjugated	conjugate	VERB
dti-1301	66	4	to	to	ADP
dti-1301	66	5	an	an	DET
dti-1301	66	6	analogue	analogue	NOUN
dti-1301	66	7	of	of	ADP
dti-1301	66	8	lhrh	lhrh	NOUN
dti-1301	66	9	was	be	AUX
dti-1301	66	10	found	find	VERB
dti-1301	66	11	to	to	PART
dti-1301	66	12	be	be	AUX
dti-1301	66	13	active	active	ADJ
dti-1301	66	14	in	in	ADP
dti-1301	66	15	stimulating	stimulate	VERB
dti-1301	66	16	ovulation	ovulation	NOUN
dti-1301	66	17	signifi	signifi	NOUN
dti-1301	66	18	cantly	cantly	ADV
dti-1301	66	19	better	well	ADV
dti-1301	66	20	in	in	ADP
dti-1301	66	21	experimental	experimental	ADJ
dti-1301	66	22	mice	mouse	NOUN
dti-1301	66	23	than	than	ADP
dti-1301	66	24	in	in	ADP
dti-1301	66	25	control	control	NOUN
dti-1301	66	26	mice	mouse	NOUN
dti-1301	66	27	following	follow	VERB
dti-1301	66	28	an	an	DET
dti-1301	66	29	oral	oral	ADJ
dti-1301	66	30	dose	dose	NOUN
dti-1301	66	31	(	(	PUNCT
dti-1301	66	32	russel	russel	PROPN
dti-1301	66	33	-	-	PUNCT
dti-1301	66	34	jones	jones	PROPN
dti-1301	66	35	,	,	PUNCT
dti-1301	66	36	1995	1995	NUM
dti-1301	66	37	)	)	PUNCT
dti-1301	66	38	.	.	PUNCT
dti-1301	67	1	habberfi	habberfi	PROPN
dti-1301	67	2	eld	eld	PROPN
dti-1301	67	3	and	and	CCONJ
dti-1301	67	4	coworkers	coworker	NOUN
dti-1301	67	5	linked	link	VERB
dti-1301	67	6	vitamin	vitamin	NOUN
dti-1301	67	7	b12	b12	NOUN
dti-1301	67	8	to	to	ADP
dti-1301	67	9	epo	epo	NOUN
dti-1301	67	10	and	and	CCONJ
dti-1301	67	11	also	also	ADV
dti-1301	67	12	to	to	ADP
dti-1301	67	13	g	g	NOUN
dti-1301	67	14	-	-	PUNCT
dti-1301	67	15	csf	csf	ADJ
dti-1301	67	16	and	and	CCONJ
dti-1301	67	17	used	use	VERB
dti-1301	67	18	these	these	DET
dti-1301	67	19	complexes	complex	NOUN
dti-1301	67	20	to	to	PART
dti-1301	67	21	examine	examine	VERB
dti-1301	67	22	the	the	DET
dti-1301	67	23	potential	potential	NOUN
dti-1301	67	24	of	of	ADP
dti-1301	67	25	the	the	DET
dti-1301	67	26	vitamin	vitamin	NOUN
dti-1301	67	27	b12	b12	NOUN
dti-1301	67	28	uptake	uptake	ADJ
dti-1301	67	29	system	system	NOUN
dti-1301	67	30	to	to	PART
dti-1301	67	31	transport	transport	VERB
dti-1301	67	32	these	these	DET
dti-1301	67	33	systems	system	NOUN
dti-1301	67	34	from	from	ADP
dti-1301	67	35	the	the	DET
dti-1301	67	36	small	small	ADJ
dti-1301	67	37	intestine	intestine	NOUN
dti-1301	67	38	to	to	ADP
dti-1301	67	39	the	the	DET
dti-1301	67	40	circulation	circulation	NOUN
dti-1301	67	41	in	in	ADP
dti-1301	67	42	rats	rat	NOUN
dti-1301	67	43	(	(	PUNCT
dti-1301	67	44	habberfi	habberfi	PROPN
dti-1301	67	45	eld	eld	NOUN
dti-1301	67	46	et	et	PROPN
dti-1301	67	47	al	al	PROPN
dti-1301	67	48	.	.	PROPN
dti-1301	67	49	1996	1996	NUM
dti-1301	67	50	)	)	PUNCT
dti-1301	67	51	.	.	PUNCT
dti-1301	68	1	it	it	PRON
dti-1301	68	2	was	be	AUX
dti-1301	68	3	shown	show	VERB
dti-1301	68	4	that	that	SCONJ
dti-1301	68	5	the	the	DET
dti-1301	68	6	vitamin	vitamin	NOUN
dti-1301	68	7	b12	b12	NOUN
dti-1301	68	8	uptake	uptake	ADJ
dti-1301	68	9	system	system	NOUN
dti-1301	68	10	could	could	AUX
dti-1301	68	11	deliver	deliver	VERB
dti-1301	68	12	epo	epo	PROPN
dti-1301	68	13	or	or	CCONJ
dti-1301	68	14	g	g	NOUN
dti-1301	68	15	-	-	PUNCT
dti-1301	68	16	csf	csf	NOUN
dti-1301	68	17	to	to	ADP
dti-1301	68	18	the	the	DET
dti-1301	68	19	circulation	circulation	NOUN
dti-1301	68	20	in	in	ADP
dti-1301	68	21	rats	rat	NOUN
dti-1301	68	22	at	at	ADP
dti-1301	68	23	a	a	DET
dti-1301	68	24	level	level	NOUN
dti-1301	68	25	4	4	NUM
dti-1301	68	26	-	-	NOUN
dti-1301	68	27	fold	fold	VERB
dti-1301	68	28	higher	high	ADJ
dti-1301	68	29	than	than	ADP
dti-1301	68	30	similar	similar	ADJ
dti-1301	68	31	administration	administration	NOUN
dti-1301	68	32	of	of	ADP
dti-1301	68	33	epo	epo	PROPN
dti-1301	68	34	or	or	CCONJ
dti-1301	68	35	g	g	NOUN
dti-1301	68	36	-	-	PUNCT
dti-1301	68	37	csf	csf	ADJ
dti-1301	68	38	alone	alone	ADV
dti-1301	68	39	.	.	PUNCT
dti-1301	69	1	the	the	DET
dti-1301	69	2	use	use	NOUN
dti-1301	69	3	of	of	ADP
dti-1301	69	4	receptor	receptor	NOUN
dti-1301	69	5	-	-	PUNCT
dti-1301	69	6	mediated	mediate	VERB
dti-1301	69	7	endocytosis	endocytosis	NOUN
dti-1301	69	8	for	for	ADP
dti-1301	69	9	oral	oral	ADJ
dti-1301	69	10	delivery	delivery	NOUN
dti-1301	69	11	of	of	ADP
dti-1301	69	12	nanoparticles	nanoparticle	NOUN
dti-1301	69	13	linked	link	VERB
dti-1301	69	14	to	to	ADP
dti-1301	69	15	vitamin	vitamin	NOUN
dti-1301	69	16	b12	b12	NOUN
dti-1301	69	17	for	for	ADP
dti-1301	69	18	systemic	systemic	ADJ
dti-1301	69	19	circulation	circulation	NOUN
dti-1301	69	20	has	have	AUX
dti-1301	69	21	also	also	ADV
dti-1301	69	22	been	be	AUX
dti-1301	69	23	demonstrated	demonstrate	VERB
dti-1301	69	24	(	(	PUNCT
dti-1301	69	25	russel	russel	PROPN
dti-1301	69	26	-	-	PUNCT
dti-1301	69	27	jones	jones	PROPN
dti-1301	69	28	,	,	PUNCT
dti-1301	69	29	1995	1995	NUM
dti-1301	69	30	)	)	PUNCT
dti-1301	69	31	.	.	PUNCT
dti-1301	70	1	nanoparticles	nanoparticle	NOUN
dti-1301	70	2	containing	contain	VERB
dti-1301	70	3	a	a	DET
dti-1301	70	4	fluorochrome	fluorochrome	NOUN
dti-1301	70	5	have	have	AUX
dti-1301	70	6	been	be	AUX
dti-1301	70	7	chemically	chemically	ADV
dti-1301	70	8	linked	link	VERB
dti-1301	70	9	to	to	ADP
dti-1301	70	10	vitamin	vitamin	NOUN
dti-1301	70	11	b12	b12	NOUN
dti-1301	70	12	and	and	CCONJ
dti-1301	70	13	administered	administer	VERB
dti-1301	70	14	to	to	ADP
dti-1301	70	15	rats	rat	NOUN
dti-1301	70	16	orally	orally	ADV
dti-1301	70	17	.	.	PUNCT
dti-1301	71	1	upon	upon	SCONJ
dti-1301	71	2	histological	histological	ADJ
dti-1301	71	3	examination	examination	NOUN
dti-1301	71	4	,	,	PUNCT
dti-1301	71	5	the	the	DET
dti-1301	71	6	fl	fl	PROPN
dti-1301	71	7	uorescent	uorescent	ADJ
dti-1301	71	8	particles	particle	NOUN
dti-1301	71	9	were	be	AUX
dti-1301	71	10	initially	initially	ADV
dti-1301	71	11	found	find	VERB
dti-1301	71	12	to	to	PART
dti-1301	71	13	be	be	AUX
dti-1301	71	14	bound	bind	VERB
dti-1301	71	15	to	to	ADP
dti-1301	71	16	the	the	DET
dti-1301	71	17	surface	surface	NOUN
dti-1301	71	18	of	of	ADP
dti-1301	71	19	the	the	DET
dti-1301	71	20	intestinal	intestinal	ADJ
dti-1301	71	21	villous	villous	ADJ
dti-1301	71	22	cells	cell	NOUN
dti-1301	71	23	.	.	PUNCT
dti-1301	72	1	some	some	DET
dti-1301	72	2	time	time	NOUN
dti-1301	72	3	later	later	ADV
dti-1301	72	4	,	,	PUNCT
dti-1301	72	5	the	the	DET
dti-1301	72	6	nanoparticles	nanoparticle	NOUN
dti-1301	72	7	could	could	AUX
dti-1301	72	8	be	be	AUX
dti-1301	72	9	found	find	VERB
dti-1301	72	10	to	to	PART
dti-1301	72	11	have	have	AUX
dti-1301	72	12	crossed	cross	VERB
dti-1301	72	13	the	the	DET
dti-1301	72	14	drug	drug	NOUN
dti-1301	72	15	target	target	NOUN
dti-1301	72	16	insights	insight	NOUN
dti-1301	72	17	2007	2007	NUM
dti-1301	72	18	:	:	PUNCT
dti-1301	72	19	274	274	NUM
dti-1301	72	20	hamman	hamman	NOUN
dti-1301	72	21	et	et	PROPN
dti-1301	72	22	al	al	PROPN
dti-1301	72	23	villous	villous	ADJ
dti-1301	72	24	epithelial	epithelial	ADJ
dti-1301	72	25	cells	cell	NOUN
dti-1301	72	26	and	and	CCONJ
dti-1301	72	27	were	be	AUX
dti-1301	72	28	observed	observe	VERB
dti-1301	72	29	below	below	ADP
dti-1301	72	30	the	the	DET
dti-1301	72	31	mucosal	mucosal	NOUN
dti-1301	72	32	cell	cell	NOUN
dti-1301	72	33	layer	layer	NOUN
dti-1301	72	34	congregating	congregate	VERB
dti-1301	72	35	in	in	ADP
dti-1301	72	36	the	the	DET
dti-1301	72	37	central	central	ADJ
dti-1301	72	38	lacteal	lacteal	NOUN
dti-1301	72	39	gland	gland	NOUN
dti-1301	72	40	for	for	ADP
dti-1301	72	41	systemic	systemic	ADJ
dti-1301	72	42	circulation	circulation	NOUN
dti-1301	72	43	(	(	PUNCT
dti-1301	72	44	russeljones	russeljone	NOUN
dti-1301	72	45	,	,	PUNCT
dti-1301	72	46	1995	1995	NUM
dti-1301	72	47	)	)	PUNCT
dti-1301	72	48	.	.	PUNCT
dti-1301	73	1	folate	folate	NOUN
dti-1301	73	2	in	in	ADP
dti-1301	73	3	rapidly	rapidly	ADV
dti-1301	73	4	dividing	divide	VERB
dti-1301	73	5	cells	cell	NOUN
dti-1301	73	6	such	such	ADJ
dti-1301	73	7	as	as	ADP
dti-1301	73	8	cancer	cancer	NOUN
dti-1301	73	9	cells	cell	NOUN
dti-1301	73	10	,	,	PUNCT
dti-1301	73	11	receptors	receptor	NOUN
dti-1301	73	12	are	be	AUX
dti-1301	73	13	up	up	ADV
dti-1301	73	14	-	-	PUNCT
dti-1301	73	15	regulated	regulate	VERB
dti-1301	73	16	and	and	CCONJ
dti-1301	73	17	can	can	AUX
dti-1301	73	18	thus	thus	ADV
dti-1301	73	19	be	be	AUX
dti-1301	73	20	differentially	differentially	ADV
dti-1301	73	21	targeted	target	VERB
dti-1301	73	22	in	in	ADP
dti-1301	73	23	drug	drug	NOUN
dti-1301	73	24	delivery	delivery	NOUN
dti-1301	73	25	strategies	strategy	NOUN
dti-1301	73	26	.	.	PUNCT
dti-1301	74	1	the	the	DET
dti-1301	74	2	folate	folate	NOUN
dti-1301	74	3	receptor	receptor	NOUN
dti-1301	74	4	is	be	AUX
dti-1301	74	5	an	an	DET
dti-1301	74	6	ideal	ideal	ADJ
dti-1301	74	7	candidate	candidate	NOUN
dti-1301	74	8	for	for	ADP
dti-1301	74	9	tumor	tumor	NOUN
dti-1301	74	10	-	-	PUNCT
dti-1301	74	11	targeted	target	VERB
dti-1301	74	12	drug	drug	NOUN
dti-1301	74	13	delivery	delivery	NOUN
dti-1301	74	14	because	because	SCONJ
dti-1301	74	15	it	it	PRON
dti-1301	74	16	is	be	AUX
dti-1301	74	17	upregulated	upregulate	VERB
dti-1301	74	18	in	in	ADP
dti-1301	74	19	many	many	ADJ
dti-1301	74	20	human	human	ADJ
dti-1301	74	21	cancers	cancer	NOUN
dti-1301	74	22	.	.	PUNCT
dti-1301	75	1	access	access	NOUN
dti-1301	75	2	to	to	ADP
dti-1301	75	3	the	the	DET
dti-1301	75	4	folate	folate	NOUN
dti-1301	75	5	receptor	receptor	NOUN
dti-1301	75	6	in	in	ADP
dti-1301	75	7	normal	normal	ADJ
dti-1301	75	8	tissues	tissue	NOUN
dti-1301	75	9	can	can	AUX
dti-1301	75	10	be	be	AUX
dti-1301	75	11	severely	severely	ADV
dti-1301	75	12	limited	limit	VERB
dti-1301	75	13	due	due	ADP
dti-1301	75	14	to	to	ADP
dti-1301	75	15	its	its	PRON
dti-1301	75	16	location	location	NOUN
dti-1301	75	17	on	on	ADP
dti-1301	75	18	the	the	DET
dti-1301	75	19	apical	apical	ADJ
dti-1301	75	20	membrane	membrane	NOUN
dti-1301	75	21	of	of	ADP
dti-1301	75	22	polarized	polarized	ADJ
dti-1301	75	23	epithelia	epithelium	NOUN
dti-1301	75	24	,	,	PUNCT
dti-1301	75	25	and	and	CCONJ
dti-1301	75	26	the	the	DET
dti-1301	75	27	density	density	NOUN
dti-1301	75	28	of	of	ADP
dti-1301	75	29	folate	folate	NOUN
dti-1301	75	30	receptors	receptor	NOUN
dti-1301	75	31	appears	appear	VERB
dti-1301	75	32	to	to	PART
dti-1301	75	33	increase	increase	VERB
dti-1301	75	34	as	as	SCONJ
dti-1301	75	35	the	the	DET
dti-1301	75	36	stage	stage	NOUN
dti-1301	75	37	or	or	CCONJ
dti-1301	75	38	grade	grade	NOUN
dti-1301	75	39	of	of	ADP
dti-1301	75	40	the	the	DET
dti-1301	75	41	cancer	cancer	NOUN
dti-1301	75	42	worsens	worsen	VERB
dti-1301	75	43	(	(	PUNCT
dti-1301	75	44	lu	lu	INTJ
dti-1301	75	45	et	et	PROPN
dti-1301	75	46	al	al	PROPN
dti-1301	75	47	.	.	PROPN
dti-1301	75	48	2002	2002	NUM
dti-1301	75	49	)	)	PUNCT
dti-1301	75	50	.	.	PUNCT
dti-1301	76	1	the	the	DET
dti-1301	76	2	conjugation	conjugation	NOUN
dti-1301	76	3	of	of	ADP
dti-1301	76	4	folic	folic	ADJ
dti-1301	76	5	acid	acid	NOUN
dti-1301	76	6	via	via	ADP
dti-1301	76	7	its	its	PRON
dti-1301	76	8	γ	γ	ADJ
dti-1301	76	9	-	-	ADJ
dti-1301	76	10	carboxylic	carboxylic	ADJ
dti-1301	76	11	group	group	NOUN
dti-1301	76	12	has	have	AUX
dti-1301	76	13	resulted	result	VERB
dti-1301	76	14	in	in	ADP
dti-1301	76	15	drug	drug	NOUN
dti-1301	76	16	binding	bind	VERB
dti-1301	76	17	to	to	ADP
dti-1301	76	18	cells	cell	NOUN
dti-1301	76	19	expressing	express	VERB
dti-1301	76	20	the	the	DET
dti-1301	76	21	folate	folate	NOUN
dti-1301	76	22	receptor	receptor	NOUN
dti-1301	76	23	and	and	CCONJ
dti-1301	76	24	consequently	consequently	ADV
dti-1301	76	25	endocytosis	endocytosis	NOUN
dti-1301	76	26	taking	take	VERB
dti-1301	76	27	place	place	NOUN
dti-1301	76	28	(	(	PUNCT
dti-1301	76	29	lu	lu	NOUN
dti-1301	76	30	et	et	PROPN
dti-1301	76	31	al	al	PROPN
dti-1301	76	32	.	.	PROPN
dti-1301	76	33	2002	2002	NUM
dti-1301	76	34	)	)	PUNCT
dti-1301	76	35	.	.	PUNCT
dti-1301	77	1	folic	folic	NOUN
dti-1301	77	2	acid	acid	NOUN
dti-1301	77	3	has	have	AUX
dti-1301	77	4	been	be	AUX
dti-1301	77	5	linked	link	VERB
dti-1301	77	6	to	to	ADP
dti-1301	77	7	both	both	DET
dti-1301	77	8	drugs	drug	NOUN
dti-1301	77	9	of	of	ADP
dti-1301	77	10	low	low	ADJ
dti-1301	77	11	molecular	molecular	ADJ
dti-1301	77	12	weight	weight	NOUN
dti-1301	77	13	and	and	CCONJ
dti-1301	77	14	the	the	DET
dti-1301	77	15	macromolecular	macromolecular	NOUN
dti-1301	77	16	complexes	complex	NOUN
dti-1301	77	17	as	as	ADP
dti-1301	77	18	a	a	DET
dti-1301	77	19	means	means	NOUN
dti-1301	77	20	of	of	ADP
dti-1301	77	21	targeting	target	VERB
dti-1301	77	22	the	the	DET
dti-1301	77	23	attached	attached	ADJ
dti-1301	77	24	molecules	molecule	NOUN
dti-1301	77	25	to	to	ADP
dti-1301	77	26	malignant	malignant	ADJ
dti-1301	77	27	cells	cell	NOUN
dti-1301	77	28	(	(	PUNCT
dti-1301	77	29	lu	lu	NOUN
dti-1301	77	30	et	et	PROPN
dti-1301	77	31	al	al	PROPN
dti-1301	77	32	.	.	PROPN
dti-1301	77	33	2002	2002	NUM
dti-1301	77	34	)	)	PUNCT
dti-1301	77	35	.	.	PUNCT
dti-1301	78	1	although	although	SCONJ
dti-1301	78	2	this	this	DET
dti-1301	78	3	conjugation	conjugation	NOUN
dti-1301	78	4	has	have	AUX
dti-1301	78	5	been	be	AUX
dti-1301	78	6	shown	show	VERB
dti-1301	78	7	to	to	PART
dti-1301	78	8	enhance	enhance	VERB
dti-1301	78	9	the	the	DET
dti-1301	78	10	delivery	delivery	NOUN
dti-1301	78	11	of	of	ADP
dti-1301	78	12	macromolecules	macromolecule	NOUN
dti-1301	78	13	to	to	PART
dti-1301	78	14	folate	folate	VERB
dti-1301	78	15	receptor	receptor	NOUN
dti-1301	78	16	-	-	PUNCT
dti-1301	78	17	expressing	express	VERB
dti-1301	78	18	cancer	cancer	NOUN
dti-1301	78	19	cells	cell	NOUN
dti-1301	78	20	in	in	ADP
dti-1301	78	21	almost	almost	ADV
dti-1301	78	22	all	all	PRON
dti-1301	78	23	in	in	ADV
dti-1301	78	24	vitro	vitro	X
dti-1301	78	25	situations	situation	NOUN
dti-1301	78	26	tested	test	VERB
dti-1301	78	27	,	,	PUNCT
dti-1301	78	28	mixed	mixed	ADJ
dti-1301	78	29	effects	effect	NOUN
dti-1301	78	30	have	have	AUX
dti-1301	78	31	however	however	ADV
dti-1301	78	32	,	,	PUNCT
dti-1301	78	33	been	be	AUX
dti-1301	78	34	observed	observe	VERB
dti-1301	78	35	when	when	SCONJ
dti-1301	78	36	conducting	conduct	VERB
dti-1301	78	37	similar	similar	ADJ
dti-1301	78	38	studies	study	NOUN
dti-1301	78	39	in	in	ADP
dti-1301	78	40	vivo	vivo	ADJ
dti-1301	78	41	conditions	condition	NOUN
dti-1301	78	42	.	.	PUNCT
dti-1301	79	1	despite	despite	SCONJ
dti-1301	79	2	these	these	DET
dti-1301	79	3	mixed	mixed	ADJ
dti-1301	79	4	effects	effect	NOUN
dti-1301	79	5	,	,	PUNCT
dti-1301	79	6	prominent	prominent	ADJ
dti-1301	79	7	examples	example	NOUN
dti-1301	79	8	do	do	AUX
dti-1301	79	9	exist	exist	VERB
dti-1301	79	10	where	where	SCONJ
dti-1301	79	11	folate	folate	NOUN
dti-1301	79	12	targeting	targeting	NOUN
dti-1301	79	13	has	have	AUX
dti-1301	79	14	signifi	signifi	NOUN
dti-1301	79	15	cantly	cantly	ADV
dti-1301	79	16	improved	improve	VERB
dti-1301	79	17	the	the	DET
dti-1301	79	18	outcome	outcome	NOUN
dti-1301	79	19	of	of	ADP
dti-1301	79	20	a	a	DET
dti-1301	79	21	macromolecule	macromolecule	NOUN
dti-1301	79	22	-	-	PUNCT
dti-1301	79	23	based	base	VERB
dti-1301	79	24	therapy	therapy	NOUN
dti-1301	79	25	,	,	PUNCT
dti-1301	79	26	leading	lead	VERB
dti-1301	79	27	to	to	ADP
dti-1301	79	28	complete	complete	ADJ
dti-1301	79	29	remission	remission	NOUN
dti-1301	79	30	of	of	ADP
dti-1301	79	31	established	establish	VERB
dti-1301	79	32	tumors	tumor	NOUN
dti-1301	79	33	(	(	PUNCT
dti-1301	79	34	ward	ward	INTJ
dti-1301	79	35	,	,	PUNCT
dti-1301	79	36	2000	2000	NUM
dti-1301	79	37	;	;	PUNCT
dti-1301	79	38	lu	lu	PROPN
dti-1301	79	39	et	et	PROPN
dti-1301	79	40	al	al	PROPN
dti-1301	79	41	.	.	PROPN
dti-1301	79	42	2002	2002	NUM
dti-1301	79	43	)	)	PUNCT
dti-1301	79	44	.	.	PUNCT
dti-1301	80	1	for	for	ADP
dti-1301	80	2	example	example	NOUN
dti-1301	80	3	,	,	PUNCT
dti-1301	80	4	folate	folate	VERB
dti-1301	80	5	receptor	receptor	NOUN
dti-1301	80	6	-	-	PUNCT
dti-1301	80	7	targeted	target	VERB
dti-1301	80	8	delivery	delivery	NOUN
dti-1301	80	9	of	of	ADP
dti-1301	80	10	liposomal	liposomal	ADJ
dti-1301	80	11	daunorubicin	daunorubicin	PROPN
dti-1301	80	12	to	to	PART
dti-1301	80	13	folate	folate	VERB
dti-1301	80	14	receptor	receptor	NOUN
dti-1301	80	15	expressing	express	VERB
dti-1301	80	16	cells	cell	NOUN
dti-1301	80	17	was	be	AUX
dti-1301	80	18	found	find	VERB
dti-1301	80	19	to	to	PART
dti-1301	80	20	have	have	VERB
dti-1301	80	21	signifi	signifi	NOUN
dti-1301	80	22	cantly	cantly	ADV
dti-1301	80	23	increased	increase	VERB
dti-1301	80	24	drug	drug	NOUN
dti-1301	80	25	cellular	cellular	ADJ
dti-1301	80	26	uptake	uptake	NOUN
dti-1301	80	27	and	and	CCONJ
dti-1301	80	28	cytotoxicity	cytotoxicity	NOUN
dti-1301	80	29	compared	compare	VERB
dti-1301	80	30	to	to	ADP
dti-1301	80	31	other	other	ADJ
dti-1301	80	32	cells	cell	NOUN
dti-1301	80	33	(	(	PUNCT
dti-1301	80	34	ni	ni	PROPN
dti-1301	80	35	et	et	PROPN
dti-1301	80	36	al	al	PROPN
dti-1301	80	37	.	.	PROPN
dti-1301	80	38	2002	2002	NUM
dti-1301	80	39	)	)	PUNCT
dti-1301	80	40	.	.	PUNCT
dti-1301	81	1	transferrin	transferrin	NOUN
dti-1301	81	2	the	the	DET
dti-1301	81	3	use	use	NOUN
dti-1301	81	4	of	of	ADP
dti-1301	81	5	the	the	DET
dti-1301	81	6	transferrin	transferrin	NOUN
dti-1301	81	7	receptor	receptor	NOUN
dti-1301	81	8	for	for	ADP
dti-1301	81	9	targeted	target	VERB
dti-1301	81	10	drug	drug	NOUN
dti-1301	81	11	delivery	delivery	NOUN
dti-1301	81	12	has	have	AUX
dti-1301	81	13	also	also	ADV
dti-1301	81	14	been	be	AUX
dti-1301	81	15	receiving	receive	VERB
dti-1301	81	16	attention	attention	NOUN
dti-1301	81	17	in	in	ADP
dti-1301	81	18	literature	literature	NOUN
dti-1301	81	19	in	in	ADP
dti-1301	81	20	recent	recent	ADJ
dti-1301	81	21	years	year	NOUN
dti-1301	81	22	(	(	PUNCT
dti-1301	81	23	xu	xu	INTJ
dti-1301	81	24	et	et	PROPN
dti-1301	81	25	al	al	PROPN
dti-1301	81	26	.	.	PROPN
dti-1301	81	27	2001	2001	NUM
dti-1301	81	28	;	;	PUNCT
dti-1301	82	1	qian	qian	PROPN
dti-1301	82	2	et	et	PROPN
dti-1301	82	3	al	al	PROPN
dti-1301	82	4	.	.	PROPN
dti-1301	82	5	2002	2002	NUM
dti-1301	82	6	;	;	PUNCT
dti-1301	82	7	kovar	kovar	PROPN
dti-1301	82	8	et	et	PROPN
dti-1301	82	9	al	al	PROPN
dti-1301	82	10	.	.	PROPN
dti-1301	82	11	2002	2002	NUM
dti-1301	82	12	;	;	PUNCT
dti-1301	82	13	kursa	kursa	PROPN
dti-1301	82	14	et	et	PROPN
dti-1301	82	15	al	al	PROPN
dti-1301	82	16	.	.	PROPN
dti-1301	82	17	2003	2003	NUM
dti-1301	82	18	)	)	PUNCT
dti-1301	82	19	.	.	PUNCT
dti-1301	83	1	high	high	ADJ
dti-1301	83	2	levels	level	NOUN
dti-1301	83	3	of	of	ADP
dti-1301	83	4	transferrin	transferrin	NOUN
dti-1301	83	5	receptors	receptor	NOUN
dti-1301	83	6	are	be	AUX
dti-1301	83	7	expressed	express	VERB
dti-1301	83	8	on	on	ADP
dti-1301	83	9	the	the	DET
dti-1301	83	10	surface	surface	NOUN
dti-1301	83	11	of	of	ADP
dti-1301	83	12	actively	actively	ADV
dti-1301	83	13	metabolizing	metabolize	VERB
dti-1301	83	14	cells	cell	NOUN
dti-1301	83	15	(	(	PUNCT
dti-1301	83	16	iacopetta	iacopetta	NOUN
dti-1301	83	17	et	et	PROPN
dti-1301	83	18	al	al	PROPN
dti-1301	83	19	.	.	PROPN
dti-1301	83	20	1982	1982	NUM
dti-1301	83	21	;	;	PUNCT
dti-1301	83	22	banerjee	banerjee	PROPN
dti-1301	83	23	et	et	PROPN
dti-1301	83	24	al	al	PROPN
dti-1301	83	25	.	.	PROPN
dti-1301	83	26	1986	1986	NUM
dti-1301	83	27	)	)	PUNCT
dti-1301	83	28	,	,	PUNCT
dti-1301	83	29	certain	certain	ADJ
dti-1301	83	30	tumors	tumor	NOUN
dti-1301	83	31	(	(	PUNCT
dti-1301	83	32	faulk	faulk	PROPN
dti-1301	83	33	et	et	PROPN
dti-1301	83	34	al	al	PROPN
dti-1301	83	35	.	.	PROPN
dti-1301	83	36	1980	1980	NUM
dti-1301	83	37	)	)	PUNCT
dti-1301	83	38	,	,	PUNCT
dti-1301	83	39	and	and	CCONJ
dti-1301	83	40	the	the	DET
dti-1301	83	41	brain	brain	NOUN
dti-1301	83	42	capillary	capillary	ADJ
dti-1301	83	43	endothelium	endothelium	NOUN
dti-1301	83	44	(	(	PUNCT
dti-1301	83	45	jefferies	jefferie	NOUN
dti-1301	83	46	et	et	PROPN
dti-1301	83	47	al	al	PROPN
dti-1301	83	48	.	.	PROPN
dti-1301	83	49	1984	1984	NUM
dti-1301	83	50	)	)	PUNCT
dti-1301	83	51	.	.	PUNCT
dti-1301	84	1	the	the	DET
dti-1301	84	2	expression	expression	NOUN
dti-1301	84	3	of	of	ADP
dti-1301	84	4	high	high	ADJ
dti-1301	84	5	levels	level	NOUN
dti-1301	84	6	of	of	ADP
dti-1301	84	7	transferrin	transferrin	ADJ
dti-1301	84	8	receptor	receptor	NOUN
dti-1301	84	9	in	in	ADP
dti-1301	84	10	the	the	DET
dti-1301	84	11	brain	brain	NOUN
dti-1301	84	12	capillary	capillary	ADJ
dti-1301	84	13	endothelium	endothelium	NOUN
dti-1301	84	14	is	be	AUX
dti-1301	84	15	particularly	particularly	ADV
dti-1301	84	16	important	important	ADJ
dti-1301	84	17	because	because	SCONJ
dti-1301	84	18	there	there	PRON
dti-1301	84	19	is	be	VERB
dti-1301	84	20	a	a	DET
dti-1301	84	21	possibility	possibility	NOUN
dti-1301	84	22	of	of	ADP
dti-1301	84	23	delivering	deliver	VERB
dti-1301	84	24	drugs	drug	NOUN
dti-1301	84	25	across	across	ADP
dti-1301	84	26	the	the	DET
dti-1301	84	27	blood	blood	NOUN
dti-1301	84	28	-	-	PUNCT
dti-1301	84	29	brain	brain	NOUN
dti-1301	84	30	barrier	barrier	NOUN
dti-1301	84	31	.	.	PUNCT
dti-1301	85	1	this	this	PRON
dti-1301	85	2	was	be	AUX
dti-1301	85	3	demonstrated	demonstrate	VERB
dti-1301	85	4	using	use	VERB
dti-1301	85	5	a	a	DET
dti-1301	85	6	conjugate	conjugate	NOUN
dti-1301	85	7	of	of	ADP
dti-1301	85	8	methotrexate	methotrexate	NOUN
dti-1301	85	9	with	with	ADP
dti-1301	85	10	anti	anti	ADJ
dti-1301	85	11	-	-	ADJ
dti-1301	85	12	transferrin	transferrin	ADJ
dti-1301	85	13	receptor	receptor	NOUN
dti-1301	85	14	antibody	antibody	NOUN
dti-1301	85	15	which	which	PRON
dti-1301	85	16	was	be	AUX
dti-1301	85	17	shown	show	VERB
dti-1301	85	18	to	to	PART
dti-1301	85	19	bind	bind	VERB
dti-1301	85	20	and	and	CCONJ
dti-1301	85	21	traverse	traverse	VERB
dti-1301	85	22	the	the	DET
dti-1301	85	23	blood	blood	NOUN
dti-1301	85	24	-	-	PUNCT
dti-1301	85	25	brain	brain	NOUN
dti-1301	85	26	barrier	barrier	NOUN
dti-1301	85	27	(	(	PUNCT
dti-1301	85	28	frieden	frieden	PROPN
dti-1301	85	29	et	et	PROPN
dti-1301	85	30	al	al	PROPN
dti-1301	85	31	.	.	PROPN
dti-1301	85	32	1980	1980	NUM
dti-1301	85	33	)	)	PUNCT
dti-1301	85	34	.	.	PUNCT
dti-1301	86	1	apart	apart	ADV
dti-1301	86	2	from	from	ADP
dti-1301	86	3	delivering	deliver	VERB
dti-1301	86	4	drugs	drug	NOUN
dti-1301	86	5	across	across	ADP
dti-1301	86	6	the	the	DET
dti-1301	86	7	blood	blood	NOUN
dti-1301	86	8	-	-	PUNCT
dti-1301	86	9	brain	brain	NOUN
dti-1301	86	10	barrier	barrier	NOUN
dti-1301	86	11	,	,	PUNCT
dti-1301	86	12	conjugates	conjugate	NOUN
dti-1301	86	13	of	of	ADP
dti-1301	86	14	transferrin	transferrin	NOUN
dti-1301	86	15	have	have	AUX
dti-1301	86	16	been	be	AUX
dti-1301	86	17	successfully	successfully	ADV
dti-1301	86	18	used	use	VERB
dti-1301	86	19	to	to	PART
dti-1301	86	20	selectively	selectively	ADV
dti-1301	86	21	kill	kill	VERB
dti-1301	86	22	cell	cell	NOUN
dti-1301	86	23	lines	line	NOUN
dti-1301	86	24	expressing	express	VERB
dti-1301	86	25	the	the	DET
dti-1301	86	26	transferrin	transferrin	ADJ
dti-1301	86	27	receptor	receptor	NOUN
dti-1301	86	28	in	in	ADP
dti-1301	86	29	certain	certain	ADJ
dti-1301	86	30	cancers	cancer	NOUN
dti-1301	86	31	(	(	PUNCT
dti-1301	86	32	cawley	cawley	NOUN
dti-1301	86	33	et	et	PROPN
dti-1301	86	34	al	al	PROPN
dti-1301	86	35	.	.	PROPN
dti-1301	86	36	1981	1981	NUM
dti-1301	86	37	;	;	PUNCT
dti-1301	86	38	raso	raso	NOUN
dti-1301	86	39	and	and	CCONJ
dti-1301	86	40	basala	basala	NOUN
dti-1301	86	41	,	,	PUNCT
dti-1301	86	42	1984	1984	NUM
dti-1301	86	43	)	)	PUNCT
dti-1301	86	44	.	.	PUNCT
dti-1301	87	1	furthermore	furthermore	ADV
dti-1301	87	2	,	,	PUNCT
dti-1301	87	3	polylysine	polylysine	VERB
dti-1301	87	4	conjugates	conjugate	NOUN
dti-1301	87	5	of	of	ADP
dti-1301	87	6	transferrin	transferrin	NOUN
dti-1301	87	7	in	in	ADP
dti-1301	87	8	particular	particular	ADJ
dti-1301	87	9	have	have	AUX
dti-1301	87	10	been	be	AUX
dti-1301	87	11	used	use	VERB
dti-1301	87	12	to	to	PART
dti-1301	87	13	deliver	deliver	VERB
dti-1301	87	14	dna	dna	PROPN
dti-1301	87	15	sequences	sequence	NOUN
dti-1301	87	16	to	to	PART
dti-1301	87	17	cell	cell	NOUN
dti-1301	87	18	lines	line	NOUN
dti-1301	87	19	in	in	ADP
dti-1301	87	20	culture	culture	NOUN
dti-1301	87	21	for	for	ADP
dti-1301	87	22	the	the	DET
dti-1301	87	23	development	development	NOUN
dti-1301	87	24	of	of	ADP
dti-1301	87	25	gene	gene	NOUN
dti-1301	87	26	therapy	therapy	NOUN
dti-1301	87	27	(	(	PUNCT
dti-1301	87	28	wagner	wagner	PROPN
dti-1301	87	29	et	et	PROPN
dti-1301	87	30	al	al	PROPN
dti-1301	87	31	.	.	PROPN
dti-1301	87	32	1990	1990	NUM
dti-1301	87	33	)	)	PUNCT
dti-1301	87	34	.	.	PUNCT
dti-1301	88	1	the	the	DET
dti-1301	88	2	potential	potential	ADJ
dti-1301	88	3	problem	problem	NOUN
dti-1301	88	4	with	with	ADP
dti-1301	88	5	manipulation	manipulation	NOUN
dti-1301	88	6	of	of	ADP
dti-1301	88	7	transferrin	transferrin	NOUN
dti-1301	88	8	uptake	uptake	NOUN
dti-1301	88	9	as	as	ADP
dti-1301	88	10	a	a	DET
dti-1301	88	11	means	means	NOUN
dti-1301	88	12	of	of	ADP
dti-1301	88	13	drug	drug	NOUN
dti-1301	88	14	delivery	delivery	NOUN
dti-1301	88	15	across	across	ADP
dti-1301	88	16	cells	cell	NOUN
dti-1301	88	17	is	be	AUX
dti-1301	88	18	the	the	DET
dti-1301	88	19	recyling	recyle	VERB
dti-1301	88	20	pathway	pathway	NOUN
dti-1301	88	21	through	through	ADP
dti-1301	88	22	which	which	PRON
dti-1301	88	23	both	both	CCONJ
dti-1301	88	24	transferrin	transferrin	NOUN
dti-1301	88	25	and	and	CCONJ
dti-1301	88	26	its	its	PRON
dti-1301	88	27	receptor	receptor	NOUN
dti-1301	88	28	undergo	undergo	NOUN
dti-1301	88	29	(	(	PUNCT
dti-1301	88	30	dautryvarsat	dautryvarsat	VERB
dti-1301	88	31	,	,	PUNCT
dti-1301	88	32	1986	1986	NUM
dti-1301	88	33	)	)	PUNCT
dti-1301	88	34	.	.	PUNCT
dti-1301	89	1	however	however	ADV
dti-1301	89	2	,	,	PUNCT
dti-1301	89	3	research	research	NOUN
dti-1301	89	4	fi	fi	NOUN
dti-1301	89	5	ndings	nding	NOUN
dti-1301	89	6	have	have	AUX
dti-1301	89	7	now	now	ADV
dti-1301	89	8	suggested	suggest	VERB
dti-1301	89	9	possible	possible	ADJ
dti-1301	89	10	means	mean	NOUN
dti-1301	89	11	of	of	ADP
dti-1301	89	12	modulating	modulate	VERB
dti-1301	89	13	the	the	DET
dti-1301	89	14	recycling	recycling	NOUN
dti-1301	89	15	pathway	pathway	NOUN
dti-1301	89	16	to	to	PART
dti-1301	89	17	achieve	achieve	VERB
dti-1301	89	18	greater	great	ADJ
dti-1301	89	19	transport	transport	NOUN
dti-1301	89	20	across	across	ADP
dti-1301	89	21	the	the	DET
dti-1301	89	22	cells	cell	NOUN
dti-1301	89	23	.	.	PUNCT
dti-1301	90	1	this	this	PRON
dti-1301	90	2	was	be	AUX
dti-1301	90	3	demonstrated	demonstrate	VERB
dti-1301	90	4	with	with	ADP
dti-1301	90	5	brefeldin	brefeldin	VERB
dti-1301	90	6	a	a	PRON
dti-1301	90	7	,	,	PUNCT
dti-1301	90	8	a	a	DET
dti-1301	90	9	drug	drug	NOUN
dti-1301	90	10	that	that	PRON
dti-1301	90	11	causes	cause	VERB
dti-1301	90	12	the	the	DET
dti-1301	90	13	disruption	disruption	NOUN
dti-1301	90	14	of	of	ADP
dti-1301	90	15	transport	transport	NOUN
dti-1301	90	16	of	of	ADP
dti-1301	90	17	secretory	secretory	ADJ
dti-1301	90	18	proteins	protein	NOUN
dti-1301	90	19	from	from	ADP
dti-1301	90	20	the	the	DET
dti-1301	90	21	endoplasmic	endoplasmic	ADJ
dti-1301	90	22	reticulum	reticulum	NOUN
dti-1301	90	23	to	to	PART
dti-1301	90	24	golgi	golgi	VERB
dti-1301	90	25	cisternae	cisternae	PROPN
dti-1301	90	26	(	(	PUNCT
dti-1301	90	27	wan	wan	PROPN
dti-1301	90	28	et	et	PROPN
dti-1301	90	29	al	al	PROPN
dti-1301	90	30	.	.	PROPN
dti-1301	90	31	1991	1991	NUM
dti-1301	90	32	)	)	PUNCT
dti-1301	90	33	.	.	PUNCT
dti-1301	91	1	this	this	DET
dti-1301	91	2	drug	drug	NOUN
dti-1301	91	3	showed	show	VERB
dti-1301	91	4	a	a	DET
dti-1301	91	5	capacity	capacity	NOUN
dti-1301	91	6	to	to	PART
dti-1301	91	7	cause	cause	VERB
dti-1301	91	8	a	a	DET
dti-1301	91	9	missorting	missorting	NOUN
dti-1301	91	10	of	of	ADP
dti-1301	91	11	the	the	DET
dti-1301	91	12	transferrin	transferrin	NOUN
dti-1301	91	13	receptor	receptor	NOUN
dti-1301	91	14	from	from	ADP
dti-1301	91	15	the	the	DET
dti-1301	91	16	basal	basal	NOUN
dti-1301	91	17	to	to	ADP
dti-1301	91	18	the	the	DET
dti-1301	91	19	apical	apical	ADJ
dti-1301	91	20	membrane	membrane	NOUN
dti-1301	91	21	and	and	CCONJ
dti-1301	91	22	a	a	DET
dti-1301	91	23	consequent	consequent	ADJ
dti-1301	91	24	30and	30and	NOUN
dti-1301	91	25	100	100	NUM
dti-1301	91	26	-	-	ADJ
dti-1301	91	27	fold	fold	ADJ
dti-1301	91	28	increase	increase	NOUN
dti-1301	91	29	in	in	ADP
dti-1301	91	30	the	the	DET
dti-1301	91	31	transcytosis	transcytosis	NOUN
dti-1301	91	32	of	of	ADP
dti-1301	91	33	transferrin	transferrin	NOUN
dti-1301	91	34	in	in	ADP
dti-1301	91	35	the	the	DET
dti-1301	91	36	basal	basal	NOUN
dti-1301	91	37	-	-	PUNCT
dti-1301	91	38	to	to	ADP
dti-1301	91	39	-	-	PUNCT
dti-1301	91	40	apical	apical	ADJ
dti-1301	91	41	and	and	CCONJ
dti-1301	91	42	the	the	DET
dti-1301	91	43	apical	apical	ADJ
dti-1301	91	44	-	-	PUNCT
dti-1301	91	45	to	to	ADP
dti-1301	91	46	-	-	PUNCT
dti-1301	91	47	basal	basal	NOUN
dti-1301	91	48	direction	direction	NOUN
dti-1301	91	49	,	,	PUNCT
dti-1301	91	50	respectively	respectively	ADV
dti-1301	91	51	(	(	PUNCT
dti-1301	91	52	wan	wan	PROPN
dti-1301	91	53	et	et	PROPN
dti-1301	91	54	al	al	PROPN
dti-1301	91	55	.	.	PROPN
dti-1301	91	56	1991	1991	NUM
dti-1301	91	57	)	)	PUNCT
dti-1301	91	58	.	.	PUNCT
dti-1301	92	1	similarly	similarly	ADV
dti-1301	92	2	,	,	PUNCT
dti-1301	92	3	monensin	monensin	NOUN
dti-1301	92	4	which	which	PRON
dti-1301	92	5	is	be	AUX
dti-1301	92	6	a	a	DET
dti-1301	92	7	drug	drug	NOUN
dti-1301	92	8	with	with	ADP
dti-1301	92	9	reversible	reversible	ADJ
dti-1301	92	10	disrupting	disrupt	VERB
dti-1301	92	11	activity	activity	NOUN
dti-1301	92	12	on	on	ADP
dti-1301	92	13	the	the	DET
dti-1301	92	14	golgi	golgi	NOUN
dti-1301	92	15	apparatus	apparatus	NOUN
dti-1301	92	16	(	(	PUNCT
dti-1301	92	17	wan	wan	PROPN
dti-1301	92	18	et	et	PROPN
dti-1301	92	19	al	al	PROPN
dti-1301	92	20	.	.	PROPN
dti-1301	92	21	1990	1990	NUM
dti-1301	92	22	)	)	PUNCT
dti-1301	92	23	has	have	AUX
dti-1301	92	24	been	be	AUX
dti-1301	92	25	shown	show	VERB
dti-1301	92	26	to	to	PART
dti-1301	92	27	increase	increase	VERB
dti-1301	92	28	the	the	DET
dti-1301	92	29	transcotysis	transcotysis	NOUN
dti-1301	92	30	of	of	ADP
dti-1301	92	31	transferrin	transferrin	NOUN
dti-1301	92	32	and	and	CCONJ
dti-1301	92	33	its	its	PRON
dti-1301	92	34	conjugates	conjugate	NOUN
dti-1301	92	35	in	in	ADP
dti-1301	92	36	the	the	DET
dti-1301	92	37	basal	basal	NOUN
dti-1301	92	38	-	-	PUNCT
dti-1301	92	39	to	to	ADP
dti-1301	92	40	-	-	PUNCT
dti-1301	92	41	apical	apical	ADJ
dti-1301	92	42	direction	direction	NOUN
dti-1301	92	43	by	by	ADP
dti-1301	92	44	up	up	ADP
dti-1301	92	45	to	to	PART
dti-1301	92	46	26	26	NUM
dti-1301	92	47	-	-	NOUN
dti-1301	92	48	fold	fold	VERB
dti-1301	92	49	(	(	PUNCT
dti-1301	92	50	wan	wan	PROPN
dti-1301	92	51	et	et	PROPN
dti-1301	92	52	al	al	PROPN
dti-1301	92	53	.	.	PROPN
dti-1301	92	54	1991	1991	NUM
dti-1301	92	55	)	)	PUNCT
dti-1301	92	56	.	.	PUNCT
dti-1301	93	1	membrane	membrane	NOUN
dti-1301	93	2	transporters	transporter	NOUN
dti-1301	93	3	many	many	ADJ
dti-1301	93	4	organic	organic	ADJ
dti-1301	93	5	solutes	solute	NOUN
dti-1301	93	6	such	such	ADJ
dti-1301	93	7	as	as	ADP
dti-1301	93	8	nutrients	nutrient	NOUN
dti-1301	93	9	(	(	PUNCT
dti-1301	93	10	i.e.	i.e.	X
dti-1301	93	11	amino	amino	ADJ
dti-1301	93	12	acids	acid	NOUN
dti-1301	93	13	,	,	PUNCT
dti-1301	93	14	sugars	sugar	NOUN
dti-1301	93	15	,	,	PUNCT
dti-1301	93	16	vitamins	vitamin	NOUN
dti-1301	93	17	and	and	CCONJ
dti-1301	93	18	bile	bile	NOUN
dti-1301	93	19	acids	acid	NOUN
dti-1301	93	20	)	)	PUNCT
dti-1301	93	21	and	and	CCONJ
dti-1301	93	22	neurotransmitters	neurotransmitter	NOUN
dti-1301	93	23	are	be	AUX
dti-1301	93	24	transferred	transfer	VERB
dti-1301	93	25	across	across	ADP
dti-1301	93	26	cell	cell	NOUN
dti-1301	93	27	membranes	membrane	NOUN
dti-1301	93	28	by	by	ADP
dti-1301	93	29	means	mean	NOUN
dti-1301	93	30	of	of	ADP
dti-1301	93	31	specialized	specialized	ADJ
dti-1301	93	32	transporters	transporter	NOUN
dti-1301	93	33	.	.	PUNCT
dti-1301	94	1	these	these	DET
dti-1301	94	2	carrier	carrier	NOUN
dti-1301	94	3	systems	system	NOUN
dti-1301	94	4	comprise	comprise	VERB
dti-1301	94	5	integral	integral	ADJ
dti-1301	94	6	membrane	membrane	NOUN
dti-1301	94	7	proteins	protein	NOUN
dti-1301	94	8	that	that	PRON
dti-1301	94	9	are	be	AUX
dti-1301	94	10	capable	capable	ADJ
dti-1301	94	11	of	of	ADP
dti-1301	94	12	transferring	transfer	VERB
dti-1301	94	13	substrates	substrate	NOUN
dti-1301	94	14	across	across	ADP
dti-1301	94	15	cell	cell	NOUN
dti-1301	94	16	membranes	membrane	NOUN
dti-1301	94	17	by	by	ADP
dti-1301	94	18	means	mean	NOUN
dti-1301	94	19	of	of	ADP
dti-1301	94	20	a	a	DET
dti-1301	94	21	passive	passive	ADJ
dti-1301	94	22	process	process	NOUN
dti-1301	94	23	(	(	PUNCT
dti-1301	94	24	i.e.	i.e.	X
dti-1301	94	25	through	through	ADP
dti-1301	94	26	channels	channel	NOUN
dti-1301	94	27	or	or	CCONJ
dti-1301	94	28	facilitated	facilitate	VERB
dti-1301	94	29	transporters	transporter	NOUN
dti-1301	94	30	)	)	PUNCT
dti-1301	94	31	or	or	CCONJ
dti-1301	94	32	an	an	DET
dti-1301	94	33	active	active	ADJ
dti-1301	94	34	process	process	NOUN
dti-1301	94	35	(	(	PUNCT
dti-1301	94	36	i.e.	i.e.	X
dti-1301	94	37	with	with	ADP
dti-1301	94	38	carriers	carrier	NOUN
dti-1301	94	39	)	)	PUNCT
dti-1301	94	40	.	.	PUNCT
dti-1301	95	1	carrier	carrier	NOUN
dti-1301	95	2	-	-	PUNCT
dti-1301	95	3	mediated	mediate	VERB
dti-1301	95	4	active	active	ADJ
dti-1301	95	5	transport	transport	NOUN
dti-1301	95	6	requires	require	VERB
dti-1301	95	7	energy	energy	NOUN
dti-1301	95	8	drug	drug	NOUN
dti-1301	95	9	target	target	NOUN
dti-1301	95	10	insights	insight	NOUN
dti-1301	95	11	2007	2007	NUM
dti-1301	95	12	:	:	PUNCT
dti-1301	95	13	2	2	NUM
dti-1301	95	14	75	75	NUM
dti-1301	95	15	targeted	target	VERB
dti-1301	95	16	oral	oral	ADJ
dti-1301	95	17	drug	drug	NOUN
dti-1301	95	18	delivery	delivery	NOUN
dti-1301	95	19	obtained	obtain	VERB
dti-1301	95	20	by	by	ADP
dti-1301	95	21	adenosine	adenosine	ADJ
dti-1301	95	22	tri	tri	ADJ
dti-1301	95	23	-	-	ADJ
dti-1301	95	24	phosphate	phosphate	ADJ
dti-1301	95	25	(	(	PUNCT
dti-1301	95	26	atp	atp	NOUN
dti-1301	95	27	)	)	PUNCT
dti-1301	95	28	hydrolysis	hydrolysis	NOUN
dti-1301	95	29	or	or	CCONJ
dti-1301	95	30	by	by	ADP
dti-1301	95	31	coupling	couple	VERB
dti-1301	95	32	to	to	ADP
dti-1301	95	33	the	the	DET
dti-1301	95	34	co	co	NOUN
dti-1301	95	35	-	-	NOUN
dti-1301	95	36	transport	transport	NOUN
dti-1301	95	37	of	of	ADP
dti-1301	95	38	a	a	DET
dti-1301	95	39	counterion	counterion	NOUN
dti-1301	95	40	down	down	ADP
dti-1301	95	41	its	its	PRON
dti-1301	95	42	electrochemical	electrochemical	ADJ
dti-1301	95	43	gradient	gradient	NOUN
dti-1301	95	44	(	(	PUNCT
dti-1301	95	45	e.g.	e.g.	ADV
dti-1301	95	46	na+	na+	NOUN
dti-1301	95	47	,	,	PUNCT
dti-1301	95	48	h+	h+	PROPN
dti-1301	95	49	,	,	PUNCT
dti-1301	95	50	cl	cl	NOUN
dti-1301	95	51	–	–	PUNCT
dti-1301	95	52	)	)	PUNCT
dti-1301	95	53	.	.	PUNCT
dti-1301	96	1	several	several	ADJ
dti-1301	96	2	drugs	drug	NOUN
dti-1301	96	3	and	and	CCONJ
dti-1301	96	4	pro	pro	ADJ
dti-1301	96	5	-	-	ADJ
dti-1301	96	6	drugs	drug	NOUN
dti-1301	96	7	share	share	VERB
dti-1301	96	8	this	this	DET
dti-1301	96	9	transport	transport	NOUN
dti-1301	96	10	pathway	pathway	NOUN
dti-1301	96	11	with	with	ADP
dti-1301	96	12	nutrients	nutrient	NOUN
dti-1301	96	13	and	and	CCONJ
dti-1301	96	14	it	it	PRON
dti-1301	96	15	has	have	AUX
dti-1301	96	16	been	be	AUX
dti-1301	96	17	shown	show	VERB
dti-1301	96	18	that	that	SCONJ
dti-1301	96	19	targeting	target	VERB
dti-1301	96	20	drugs	drug	NOUN
dti-1301	96	21	to	to	ADP
dti-1301	96	22	these	these	DET
dti-1301	96	23	transporter	transporter	NOUN
dti-1301	96	24	carriers	carrier	NOUN
dti-1301	96	25	can	can	AUX
dti-1301	96	26	infl	infl	VERB
dti-1301	96	27	uence	uence	NOUN
dti-1301	96	28	their	their	PRON
dti-1301	96	29	bioavailability	bioavailability	NOUN
dti-1301	96	30	as	as	ADV
dti-1301	96	31	well	well	ADV
dti-1301	96	32	as	as	ADP
dti-1301	96	33	their	their	PRON
dti-1301	96	34	distribution	distribution	NOUN
dti-1301	96	35	(	(	PUNCT
dti-1301	96	36	zhang	zhang	X
dti-1301	96	37	et	et	PROPN
dti-1301	96	38	al	al	PROPN
dti-1301	96	39	.	.	PROPN
dti-1301	96	40	2002	2002	NUM
dti-1301	96	41	;	;	PUNCT
dti-1301	96	42	steffansen	steffansen	NOUN
dti-1301	96	43	,	,	PUNCT
dti-1301	96	44	2004	2004	NUM
dti-1301	96	45	)	)	PUNCT
dti-1301	96	46	.	.	PUNCT
dti-1301	97	1	targeting	target	VERB
dti-1301	97	2	drug	drug	NOUN
dti-1301	97	3	delivery	delivery	NOUN
dti-1301	97	4	to	to	ADP
dti-1301	97	5	intestinal	intestinal	ADJ
dti-1301	97	6	nutrient	nutrient	NOUN
dti-1301	97	7	transporters	transporter	NOUN
dti-1301	97	8	has	have	AUX
dti-1301	97	9	emerged	emerge	VERB
dti-1301	97	10	as	as	ADP
dti-1301	97	11	an	an	DET
dti-1301	97	12	important	important	ADJ
dti-1301	97	13	strategy	strategy	NOUN
dti-1301	97	14	to	to	PART
dti-1301	97	15	improve	improve	VERB
dti-1301	97	16	oral	oral	ADJ
dti-1301	97	17	bioavailability	bioavailability	NOUN
dti-1301	97	18	of	of	ADP
dti-1301	97	19	poorly	poorly	ADV
dti-1301	97	20	permeating	permeate	VERB
dti-1301	97	21	therapeutic	therapeutic	ADJ
dti-1301	97	22	agents	agent	NOUN
dti-1301	97	23	.	.	PUNCT
dti-1301	98	1	this	this	DET
dti-1301	98	2	approach	approach	NOUN
dti-1301	98	3	usually	usually	ADV
dti-1301	98	4	entails	entail	VERB
dti-1301	98	5	linking	link	VERB
dti-1301	98	6	the	the	DET
dti-1301	98	7	drug	drug	NOUN
dti-1301	98	8	molecule	molecule	NOUN
dti-1301	98	9	to	to	ADP
dti-1301	98	10	a	a	DET
dti-1301	98	11	natural	natural	ADJ
dti-1301	98	12	ligand	ligand	NOUN
dti-1301	98	13	in	in	ADP
dti-1301	98	14	order	order	NOUN
dti-1301	98	15	to	to	PART
dti-1301	98	16	be	be	AUX
dti-1301	98	17	recognized	recognize	VERB
dti-1301	98	18	as	as	ADP
dti-1301	98	19	a	a	DET
dti-1301	98	20	substrate	substrate	NOUN
dti-1301	98	21	by	by	ADP
dti-1301	98	22	a	a	DET
dti-1301	98	23	specifi	specifi	PROPN
dti-1301	98	24	c	c	PROPN
dti-1301	98	25	nutrient	nutrient	NOUN
dti-1301	98	26	transporter	transporter	NOUN
dti-1301	98	27	in	in	ADP
dti-1301	98	28	the	the	DET
dti-1301	98	29	apical	apical	ADJ
dti-1301	98	30	membrane	membrane	NOUN
dti-1301	98	31	of	of	ADP
dti-1301	98	32	the	the	DET
dti-1301	98	33	epithelial	epithelial	ADJ
dti-1301	98	34	cell	cell	NOUN
dti-1301	98	35	.	.	PUNCT
dti-1301	99	1	alternatively	alternatively	ADV
dti-1301	99	2	,	,	PUNCT
dti-1301	99	3	the	the	DET
dti-1301	99	4	drug	drug	NOUN
dti-1301	99	5	molecule	molecule	NOUN
dti-1301	99	6	can	can	AUX
dti-1301	99	7	be	be	AUX
dti-1301	99	8	designed	design	VERB
dti-1301	99	9	or	or	CCONJ
dti-1301	99	10	changed	change	VERB
dti-1301	99	11	(	(	PUNCT
dti-1301	99	12	e.g.	e.g.	ADV
dti-1301	99	13	formation	formation	NOUN
dti-1301	99	14	of	of	ADP
dti-1301	99	15	derivatives	derivative	NOUN
dti-1301	99	16	or	or	CCONJ
dti-1301	99	17	pro	pro	ADJ
dti-1301	99	18	-	-	NOUN
dti-1301	99	19	drugs	drug	NOUN
dti-1301	99	20	)	)	PUNCT
dti-1301	99	21	in	in	ADP
dti-1301	99	22	such	such	DET
dti-1301	99	23	a	a	DET
dti-1301	99	24	way	way	NOUN
dti-1301	99	25	that	that	PRON
dti-1301	99	26	it	it	PRON
dti-1301	99	27	mimics	mimic	VERB
dti-1301	99	28	the	the	DET
dti-1301	99	29	three	three	NUM
dti-1301	99	30	-	-	PUNCT
dti-1301	99	31	dimensional	dimensional	ADJ
dti-1301	99	32	features	feature	NOUN
dti-1301	99	33	of	of	ADP
dti-1301	99	34	natural	natural	ADJ
dti-1301	99	35	ligands	ligand	NOUN
dti-1301	99	36	.	.	PUNCT
dti-1301	100	1	these	these	DET
dti-1301	100	2	pro	pro	ADJ
dti-1301	100	3	-	-	ADJ
dti-1301	100	4	moieties	moiety	NOUN
dti-1301	100	5	are	be	AUX
dti-1301	100	6	then	then	ADV
dti-1301	100	7	either	either	CCONJ
dti-1301	100	8	cleaved	cleave	VERB
dti-1301	100	9	within	within	ADP
dti-1301	100	10	the	the	DET
dti-1301	100	11	intracellular	intracellular	ADJ
dti-1301	100	12	environment	environment	NOUN
dti-1301	100	13	of	of	ADP
dti-1301	100	14	the	the	DET
dti-1301	100	15	epithelial	epithelial	ADJ
dti-1301	100	16	cells	cell	NOUN
dti-1301	100	17	or	or	CCONJ
dti-1301	100	18	elsewhere	elsewhere	ADV
dti-1301	100	19	in	in	ADP
dti-1301	100	20	the	the	DET
dti-1301	100	21	body	body	NOUN
dti-1301	100	22	to	to	PART
dti-1301	100	23	free	free	VERB
dti-1301	100	24	the	the	DET
dti-1301	100	25	active	active	ADJ
dti-1301	100	26	drug	drug	NOUN
dti-1301	100	27	(	(	PUNCT
dti-1301	100	28	zhang	zhang	X
dti-1301	100	29	et	et	PROPN
dti-1301	100	30	al	al	PROPN
dti-1301	100	31	.	.	PROPN
dti-1301	100	32	2002	2002	NUM
dti-1301	100	33	;	;	PUNCT
dti-1301	100	34	majumdar	majumdar	PROPN
dti-1301	100	35	et	et	PROPN
dti-1301	100	36	al	al	PROPN
dti-1301	100	37	.	.	PROPN
dti-1301	100	38	2004	2004	NUM
dti-1301	100	39	)	)	PUNCT
dti-1301	100	40	.	.	PUNCT
dti-1301	101	1	in	in	ADP
dti-1301	101	2	general	general	ADJ
dti-1301	101	3	,	,	PUNCT
dti-1301	101	4	transporter	transporter	NOUN
dti-1301	101	5	proteins	protein	NOUN
dti-1301	101	6	that	that	PRON
dti-1301	101	7	can	can	AUX
dti-1301	101	8	be	be	AUX
dti-1301	101	9	targeted	target	VERB
dti-1301	101	10	for	for	ADP
dti-1301	101	11	this	this	DET
dti-1301	101	12	purpose	purpose	NOUN
dti-1301	101	13	are	be	AUX
dti-1301	101	14	those	those	PRON
dti-1301	101	15	that	that	PRON
dti-1301	101	16	provide	provide	VERB
dti-1301	101	17	transport	transport	NOUN
dti-1301	101	18	mechanisms	mechanism	NOUN
dti-1301	101	19	for	for	ADP
dti-1301	101	20	amino	amino	ADJ
dti-1301	101	21	acids	acid	NOUN
dti-1301	101	22	,	,	PUNCT
dti-1301	101	23	dipeptides	dipeptide	NOUN
dti-1301	101	24	,	,	PUNCT
dti-1301	101	25	monosaccharides	monosaccharide	NOUN
dti-1301	101	26	,	,	PUNCT
dti-1301	101	27	monocarboxylic	monocarboxylic	ADJ
dti-1301	101	28	acids	acid	NOUN
dti-1301	101	29	,	,	PUNCT
dti-1301	101	30	organic	organic	ADJ
dti-1301	101	31	cations	cation	NOUN
dti-1301	101	32	,	,	PUNCT
dti-1301	101	33	phosphates	phosphate	NOUN
dti-1301	101	34	,	,	PUNCT
dti-1301	101	35	nucleosides	nucleoside	NOUN
dti-1301	101	36	and	and	CCONJ
dti-1301	101	37	water	water	NOUN
dti-1301	101	38	-	-	PUNCT
dti-1301	101	39	soluble	soluble	ADJ
dti-1301	101	40	vitamins	vitamin	NOUN
dti-1301	101	41	(	(	PUNCT
dti-1301	101	42	lee	lee	PROPN
dti-1301	101	43	,	,	PUNCT
dti-1301	101	44	2000	2000	NUM
dti-1301	101	45	)	)	PUNCT
dti-1301	101	46	.	.	PUNCT
dti-1301	102	1	peptide	peptide	NOUN
dti-1301	102	2	transporters	transporter	NOUN
dti-1301	102	3	exogenic	exogenic	ADJ
dti-1301	102	4	peptides	peptide	NOUN
dti-1301	102	5	are	be	AUX
dti-1301	102	6	rapidly	rapidly	ADV
dti-1301	102	7	metabolized	metabolize	VERB
dti-1301	102	8	in	in	ADP
dti-1301	102	9	the	the	DET
dti-1301	102	10	gastrointestinal	gastrointestinal	ADJ
dti-1301	102	11	tract	tract	NOUN
dti-1301	102	12	by	by	ADP
dti-1301	102	13	proteolytic	proteolytic	ADJ
dti-1301	102	14	enzymes	enzyme	NOUN
dti-1301	102	15	into	into	ADP
dti-1301	102	16	smaller	small	ADJ
dti-1301	102	17	oligopeptides	oligopeptide	NOUN
dti-1301	102	18	,	,	PUNCT
dti-1301	102	19	tripeptides	tripeptide	VERB
dti-1301	102	20	,	,	PUNCT
dti-1301	102	21	dipeptides	dipeptide	NOUN
dti-1301	102	22	as	as	ADV
dti-1301	102	23	well	well	ADV
dti-1301	102	24	as	as	ADP
dti-1301	102	25	amino	amino	ADJ
dti-1301	102	26	acids	acid	NOUN
dti-1301	102	27	.	.	PUNCT
dti-1301	103	1	while	while	SCONJ
dti-1301	103	2	the	the	DET
dti-1301	103	3	absorption	absorption	NOUN
dti-1301	103	4	of	of	ADP
dti-1301	103	5	larger	large	ADJ
dti-1301	103	6	peptides	peptide	NOUN
dti-1301	103	7	across	across	ADP
dti-1301	103	8	intestinal	intestinal	ADJ
dti-1301	103	9	epithelial	epithelial	ADJ
dti-1301	103	10	cells	cell	NOUN
dti-1301	103	11	is	be	AUX
dti-1301	103	12	restricted	restrict	VERB
dti-1301	103	13	,	,	PUNCT
dti-1301	103	14	large	large	ADJ
dti-1301	103	15	amounts	amount	NOUN
dti-1301	103	16	of	of	ADP
dti-1301	103	17	amino	amino	ADJ
dti-1301	103	18	acids	acid	NOUN
dti-1301	103	19	and	and	CCONJ
dti-1301	103	20	di/	di/	VERB
dti-1301	103	21	tripeptides	tripeptides	AUX
dti-1301	103	22	cross	cross	VERB
dti-1301	103	23	the	the	DET
dti-1301	103	24	enterocytic	enterocytic	ADJ
dti-1301	103	25	membrane	membrane	NOUN
dti-1301	103	26	by	by	ADP
dti-1301	103	27	means	mean	NOUN
dti-1301	103	28	of	of	ADP
dti-1301	103	29	transporter	transporter	NOUN
dti-1301	103	30	systems	system	NOUN
dti-1301	103	31	(	(	PUNCT
dti-1301	103	32	steffansen	steffansen	PROPN
dti-1301	103	33	et	et	PROPN
dti-1301	103	34	al	al	PROPN
dti-1301	103	35	.	.	PROPN
dti-1301	103	36	2005	2005	NUM
dti-1301	103	37	)	)	PUNCT
dti-1301	103	38	.	.	PUNCT
dti-1301	104	1	human	human	ADJ
dti-1301	104	2	intestinal	intestinal	ADJ
dti-1301	104	3	membrane	membrane	NOUN
dti-1301	104	4	transporters	transporter	NOUN
dti-1301	104	5	involved	involve	VERB
dti-1301	104	6	in	in	ADP
dti-1301	104	7	the	the	DET
dti-1301	104	8	uptake	uptake	NOUN
dti-1301	104	9	of	of	ADP
dti-1301	104	10	di	di	NOUN
dti-1301	104	11	/	/	SYM
dti-1301	104	12	tripeptides	tripeptide	NOUN
dti-1301	104	13	include	include	VERB
dti-1301	104	14	the	the	DET
dti-1301	104	15	peptide	peptide	ADJ
dti-1301	104	16	transporter	transporter	NOUN
dti-1301	104	17	pept1	pept1	PROPN
dti-1301	104	18	,	,	PUNCT
dti-1301	104	19	the	the	DET
dti-1301	104	20	peptide	peptide	NOUN
dti-1301	104	21	/	/	SYM
dti-1301	104	22	histidin	histidin	NOUN
dti-1301	104	23	transporters	transporter	NOUN
dti-1301	104	24	pht1	pht1	ADJ
dti-1301	104	25	,	,	PUNCT
dti-1301	104	26	pht2	pht2	NOUN
dti-1301	104	27	and	and	CCONJ
dti-1301	104	28	the	the	DET
dti-1301	104	29	peptide	peptide	NOUN
dti-1301	104	30	transporter	transporter	NOUN
dti-1301	104	31	pt1	pt1	PROPN
dti-1301	104	32	.	.	PUNCT
dti-1301	105	1	the	the	DET
dti-1301	105	2	peptide	peptide	ADJ
dti-1301	105	3	transporter	transporter	NOUN
dti-1301	105	4	pept2	pept2	NOUN
dti-1301	105	5	is	be	AUX
dti-1301	105	6	found	find	VERB
dti-1301	105	7	in	in	ADP
dti-1301	105	8	other	other	ADJ
dti-1301	105	9	types	type	NOUN
dti-1301	105	10	of	of	ADP
dti-1301	105	11	tissue	tissue	NOUN
dti-1301	105	12	than	than	SCONJ
dti-1301	105	13	the	the	DET
dti-1301	105	14	small	small	ADJ
dti-1301	105	15	intestine	intestine	NOUN
dti-1301	105	16	and	and	CCONJ
dti-1301	105	17	only	only	ADV
dti-1301	105	18	limited	limited	ADJ
dti-1301	105	19	information	information	NOUN
dti-1301	105	20	is	be	AUX
dti-1301	105	21	available	available	ADJ
dti-1301	105	22	on	on	ADP
dti-1301	105	23	pht1	pht1	PROPN
dti-1301	105	24	and	and	CCONJ
dti-1301	105	25	pt1	pt1	NOUN
dti-1301	105	26	,	,	PUNCT
dti-1301	105	27	but	but	CCONJ
dti-1301	105	28	pept1	pept1	NOUN
dti-1301	105	29	is	be	AUX
dti-1301	105	30	widely	widely	ADV
dti-1301	105	31	described	describe	VERB
dti-1301	105	32	in	in	ADP
dti-1301	105	33	the	the	DET
dti-1301	105	34	literature	literature	NOUN
dti-1301	105	35	(	(	PUNCT
dti-1301	105	36	steffansen	steffansen	PROPN
dti-1301	105	37	et	et	PROPN
dti-1301	105	38	al	al	PROPN
dti-1301	105	39	.	.	PROPN
dti-1301	105	40	2004	2004	NUM
dti-1301	105	41	)	)	PUNCT
dti-1301	105	42	.	.	PUNCT
dti-1301	106	1	pept1	pept1	PROPN
dti-1301	106	2	is	be	AUX
dti-1301	106	3	an	an	DET
dti-1301	106	4	h+-coupled	h+-coupled	ADJ
dti-1301	106	5	,	,	PUNCT
dti-1301	106	6	active	active	ADJ
dti-1301	106	7	transport	transport	NOUN
dti-1301	106	8	system	system	NOUN
dti-1301	106	9	with	with	ADP
dti-1301	106	10	a	a	DET
dti-1301	106	11	broad	broad	ADJ
dti-1301	106	12	substrate	substrate	NOUN
dti-1301	106	13	specifi	specifi	PROPN
dti-1301	106	14	city	city	PROPN
dti-1301	106	15	,	,	PUNCT
dti-1301	106	16	which	which	PRON
dti-1301	106	17	may	may	AUX
dti-1301	106	18	range	range	VERB
dti-1301	106	19	from	from	ADP
dti-1301	106	20	natural	natural	ADJ
dti-1301	106	21	substrates	substrate	NOUN
dti-1301	106	22	in	in	ADP
dti-1301	106	23	food	food	NOUN
dti-1301	106	24	such	such	ADJ
dti-1301	106	25	as	as	ADP
dti-1301	106	26	diand	diand	NOUN
dti-1301	106	27	tripeptides	tripeptide	NOUN
dti-1301	106	28	to	to	PART
dti-1301	106	29	peptide	peptide	VERB
dti-1301	106	30	-	-	PUNCT
dti-1301	106	31	like	like	ADJ
dti-1301	106	32	therapeutic	therapeutic	ADJ
dti-1301	106	33	agents	agent	NOUN
dti-1301	106	34	such	such	ADJ
dti-1301	106	35	as	as	ADP
dti-1301	106	36	β	β	NOUN
dti-1301	106	37	-	-	NOUN
dti-1301	106	38	lactam	lactam	NOUN
dti-1301	106	39	antibiotics	antibiotic	NOUN
dti-1301	106	40	and	and	CCONJ
dti-1301	106	41	angiotensin	angiotensin	NOUN
dti-1301	106	42	-	-	PUNCT
dti-1301	106	43	converting	convert	VERB
dti-1301	106	44	enzyme	enzyme	NOUN
dti-1301	106	45	(	(	PUNCT
dti-1301	106	46	ace	ace	NOUN
dti-1301	106	47	)	)	PUNCT
dti-1301	106	48	inhibitors	inhibitor	NOUN
dti-1301	106	49	(	(	PUNCT
dti-1301	106	50	zhang	zhang	X
dti-1301	106	51	et	et	PROPN
dti-1301	106	52	al	al	PROPN
dti-1301	106	53	.	.	PROPN
dti-1301	106	54	2002	2002	NUM
dti-1301	106	55	)	)	PUNCT
dti-1301	106	56	.	.	PUNCT
dti-1301	107	1	even	even	ADV
dti-1301	107	2	substances	substance	NOUN
dti-1301	107	3	without	without	ADP
dti-1301	107	4	an	an	DET
dti-1301	107	5	obvious	obvious	ADJ
dti-1301	107	6	peptide	peptide	NOUN
dti-1301	107	7	bond	bond	NOUN
dti-1301	107	8	such	such	ADJ
dti-1301	107	9	as	as	ADP
dti-1301	107	10	δ	δ	NOUN
dti-1301	107	11	-	-	PUNCT
dti-1301	107	12	amino	amino	ADJ
dti-1301	107	13	-	-	PUNCT
dti-1301	107	14	levulinic	levulinic	NOUN
dti-1301	107	15	acid	acid	NOUN
dti-1301	107	16	and	and	CCONJ
dti-1301	107	17	ω	ω	VERB
dti-1301	107	18	-	-	ADJ
dti-1301	107	19	amino	amino	ADJ
dti-1301	107	20	fatty	fatty	NOUN
dti-1301	107	21	acids	acid	NOUN
dti-1301	107	22	are	be	AUX
dti-1301	107	23	substrates	substrate	NOUN
dti-1301	107	24	for	for	ADP
dti-1301	107	25	this	this	DET
dti-1301	107	26	transporter	transporter	NOUN
dti-1301	107	27	(	(	PUNCT
dti-1301	107	28	lee	lee	PROPN
dti-1301	107	29	,	,	PUNCT
dti-1301	107	30	2000	2000	NUM
dti-1301	107	31	)	)	PUNCT
dti-1301	107	32	.	.	PUNCT
dti-1301	108	1	due	due	ADP
dti-1301	108	2	to	to	ADP
dti-1301	108	3	the	the	DET
dti-1301	108	4	wide	wide	ADJ
dti-1301	108	5	substrate	substrate	NOUN
dti-1301	108	6	specifi	specifi	PROPN
dti-1301	108	7	city	city	NOUN
dti-1301	108	8	of	of	ADP
dti-1301	108	9	pept1	pept1	PROPN
dti-1301	108	10	,	,	PUNCT
dti-1301	108	11	various	various	ADJ
dti-1301	108	12	approaches	approach	NOUN
dti-1301	108	13	with	with	ADP
dti-1301	108	14	pro	pro	ADJ
dti-1301	108	15	-	-	NOUN
dti-1301	108	16	drugs	drug	NOUN
dti-1301	108	17	that	that	PRON
dti-1301	108	18	are	be	AUX
dti-1301	108	19	aimed	aim	VERB
dti-1301	108	20	at	at	ADP
dti-1301	108	21	targeting	target	VERB
dti-1301	108	22	this	this	DET
dti-1301	108	23	transporter	transporter	NOUN
dti-1301	108	24	have	have	AUX
dti-1301	108	25	been	be	AUX
dti-1301	108	26	attempted	attempt	VERB
dti-1301	108	27	.	.	PUNCT
dti-1301	109	1	one	one	NUM
dti-1301	109	2	approach	approach	NOUN
dti-1301	109	3	is	be	AUX
dti-1301	109	4	to	to	PART
dti-1301	109	5	form	form	VERB
dti-1301	109	6	dipeptidyl	dipeptidyl	NOUN
dti-1301	109	7	based	base	VERB
dti-1301	109	8	pro	pro	ADJ
dti-1301	109	9	-	-	NOUN
dti-1301	109	10	drugs	drug	NOUN
dti-1301	109	11	by	by	ADP
dti-1301	109	12	linking	link	VERB
dti-1301	109	13	dipeptides	dipeptide	NOUN
dti-1301	109	14	with	with	ADP
dti-1301	109	15	intrinsic	intrinsic	ADJ
dti-1301	109	16	affi	affi	PROPN
dti-1301	109	17	nity	nity	NOUN
dti-1301	109	18	for	for	ADP
dti-1301	109	19	pept1	pept1	PROPN
dti-1301	109	20	to	to	ADP
dti-1301	109	21	the	the	DET
dti-1301	109	22	drug	drug	NOUN
dti-1301	109	23	molecule	molecule	NOUN
dti-1301	109	24	such	such	ADJ
dti-1301	109	25	as	as	ADP
dti-1301	109	26	asp	asp	PROPN
dti-1301	109	27	-	-	PUNCT
dti-1301	109	28	sar	sar	PROPN
dti-1301	109	29	and	and	CCONJ
dti-1301	109	30	glu	glu	PROPN
dti-1301	109	31	-	-	PUNCT
dti-1301	109	32	sar	sar	NOUN
dti-1301	109	33	.	.	PUNCT
dti-1301	110	1	it	it	PRON
dti-1301	110	2	was	be	AUX
dti-1301	110	3	shown	show	VERB
dti-1301	110	4	that	that	SCONJ
dti-1301	110	5	a	a	DET
dti-1301	110	6	variety	variety	NOUN
dti-1301	110	7	of	of	ADP
dti-1301	110	8	derivatized	derivatize	VERB
dti-1301	110	9	dipeptides	dipeptide	NOUN
dti-1301	110	10	target	target	NOUN
dti-1301	110	11	pept1	pept1	VERB
dti-1301	110	12	to	to	PART
dti-1301	110	13	improve	improve	VERB
dti-1301	110	14	bioavailability	bioavailability	NOUN
dti-1301	110	15	,	,	PUNCT
dti-1301	110	16	for	for	ADP
dti-1301	110	17	example	example	NOUN
dti-1301	110	18	the	the	DET
dti-1301	110	19	dipeptidyl	dipeptidyl	ADJ
dti-1301	110	20	derivatives	derivative	NOUN
dti-1301	110	21	of	of	ADP
dti-1301	110	22	α	α	NOUN
dti-1301	110	23	-	-	ADJ
dti-1301	110	24	methyldopa	methyldopa	ADV
dti-1301	110	25	as	as	ADV
dti-1301	110	26	well	well	ADV
dti-1301	110	27	as	as	ADP
dti-1301	110	28	p	p	NOUN
dti-1301	110	29	-	-	PUNCT
dti-1301	110	30	glu	glu	NOUN
dti-1301	110	31	-	-	PUNCT
dti-1301	110	32	l	l	NOUN
dti-1301	110	33	-	-	PUNCT
dti-1301	110	34	dopa	dopa	NOUN
dti-1301	110	35	-	-	PUNCT
dti-1301	110	36	pro	pro	ADJ
dti-1301	110	37	and	and	CCONJ
dti-1301	110	38	l	l	NOUN
dti-1301	110	39	-	-	PUNCT
dti-1301	110	40	dopa	dopa	NOUN
dti-1301	110	41	-	-	PUNCT
dti-1301	110	42	phe	phe	NOUN
dti-1301	110	43	showed	show	VERB
dti-1301	110	44	enhanced	enhanced	ADJ
dti-1301	110	45	permeability	permeability	NOUN
dti-1301	110	46	as	as	SCONJ
dti-1301	110	47	compared	compare	VERB
dti-1301	110	48	to	to	ADP
dti-1301	110	49	the	the	DET
dti-1301	110	50	parent	parent	NOUN
dti-1301	110	51	drugs	drug	NOUN
dti-1301	110	52	respectively	respectively	ADV
dti-1301	110	53	.	.	PUNCT
dti-1301	111	1	another	another	DET
dti-1301	111	2	approach	approach	NOUN
dti-1301	111	3	to	to	PART
dti-1301	111	4	target	target	VERB
dti-1301	111	5	pept1	pept1	NOUN
dti-1301	111	6	is	be	AUX
dti-1301	111	7	to	to	PART
dti-1301	111	8	form	form	VERB
dti-1301	111	9	amino	amino	NOUN
dti-1301	111	10	acid	acid	NOUN
dti-1301	111	11	pro	pro	ADJ
dti-1301	111	12	-	-	NOUN
dti-1301	111	13	drugs	drug	NOUN
dti-1301	111	14	,	,	PUNCT
dti-1301	111	15	for	for	ADP
dti-1301	111	16	example	example	NOUN
dti-1301	111	17	the	the	DET
dti-1301	111	18	l	l	NOUN
dti-1301	111	19	-	-	ADJ
dti-1301	111	20	valyl	valyl	ADJ
dti-1301	111	21	ester	ester	NOUN
dti-1301	111	22	pro	pro	ADJ
dti-1301	111	23	-	-	ADJ
dti-1301	111	24	drug	drug	NOUN
dti-1301	111	25	of	of	ADP
dti-1301	111	26	acyclovir	acyclovir	PROPN
dti-1301	111	27	increased	increase	VERB
dti-1301	111	28	its	its	PRON
dti-1301	111	29	oral	oral	ADJ
dti-1301	111	30	bioavailability	bioavailability	NOUN
dti-1301	111	31	3–5	3–5	NUM
dti-1301	111	32	times	time	NOUN
dti-1301	111	33	(	(	PUNCT
dti-1301	111	34	steffansen	steffansen	PROPN
dti-1301	111	35	et	et	PROPN
dti-1301	111	36	al	al	PROPN
dti-1301	111	37	.	.	PROPN
dti-1301	111	38	2004	2004	NUM
dti-1301	111	39	)	)	PUNCT
dti-1301	111	40	.	.	PUNCT
dti-1301	112	1	enalapril	enalapril	PROPN
dti-1301	112	2	is	be	AUX
dti-1301	112	3	an	an	DET
dti-1301	112	4	ester	ester	NOUN
dti-1301	112	5	pro	pro	ADJ
dti-1301	112	6	-	-	NOUN
dti-1301	112	7	drug	drug	NOUN
dti-1301	112	8	of	of	ADP
dti-1301	112	9	the	the	DET
dti-1301	112	10	ace	ace	NOUN
dti-1301	112	11	-	-	PUNCT
dti-1301	112	12	inhibitor	inhibitor	NOUN
dti-1301	112	13	,	,	PUNCT
dti-1301	112	14	enalaprilat	enalaprilat	NOUN
dti-1301	112	15	and	and	CCONJ
dti-1301	112	16	is	be	AUX
dti-1301	112	17	a	a	DET
dti-1301	112	18	substrate	substrate	NOUN
dti-1301	112	19	for	for	ADP
dti-1301	112	20	pept1	pept1	PROPN
dti-1301	112	21	.	.	PUNCT
dti-1301	113	1	formation	formation	NOUN
dti-1301	113	2	of	of	ADP
dti-1301	113	3	this	this	DET
dti-1301	113	4	pro	pro	ADJ
dti-1301	113	5	-	-	ADJ
dti-1301	113	6	drug	drug	NOUN
dti-1301	113	7	of	of	ADP
dti-1301	113	8	enalaprilat	enalaprilat	NOUN
dti-1301	113	9	resulted	result	VERB
dti-1301	113	10	in	in	ADP
dti-1301	113	11	an	an	DET
dti-1301	113	12	increase	increase	NOUN
dti-1301	113	13	of	of	ADP
dti-1301	113	14	the	the	DET
dti-1301	113	15	oral	oral	ADJ
dti-1301	113	16	bioavailability	bioavailability	NOUN
dti-1301	113	17	from	from	ADP
dti-1301	113	18	3–12	3–12	NUM
dti-1301	113	19	%	%	NOUN
dti-1301	113	20	to	to	ADP
dti-1301	113	21	60–70	60–70	NUM
dti-1301	113	22	%	%	NOUN
dti-1301	113	23	(	(	PUNCT
dti-1301	113	24	zhang	zhang	PROPN
dti-1301	113	25	et	et	PROPN
dti-1301	113	26	al	al	PROPN
dti-1301	113	27	.	.	PROPN
dti-1301	113	28	2002	2002	NUM
dti-1301	113	29	)	)	PUNCT
dti-1301	113	30	.	.	PUNCT
dti-1301	114	1	although	although	SCONJ
dti-1301	114	2	pept1	pept1	PROPN
dti-1301	114	3	targeted	target	VERB
dti-1301	114	4	amino	amino	NOUN
dti-1301	114	5	acid	acid	NOUN
dti-1301	114	6	and	and	CCONJ
dti-1301	114	7	dipeptidyl	dipeptidyl	ADJ
dti-1301	114	8	pro	pro	ADJ
dti-1301	114	9	-	-	ADJ
dti-1301	114	10	drugs	drug	NOUN
dti-1301	114	11	show	show	VERB
dti-1301	114	12	potential	potential	NOUN
dti-1301	114	13	for	for	ADP
dti-1301	114	14	the	the	DET
dti-1301	114	15	effective	effective	ADJ
dti-1301	114	16	delivery	delivery	NOUN
dti-1301	114	17	of	of	ADP
dti-1301	114	18	di	di	NOUN
dti-1301	114	19	/	/	SYM
dti-1301	114	20	tripeptidomimetics	tripeptidomimetic	NOUN
dti-1301	114	21	and	and	CCONJ
dti-1301	114	22	small	small	ADJ
dti-1301	114	23	drug	drug	NOUN
dti-1301	114	24	molecules	molecule	NOUN
dti-1301	114	25	,	,	PUNCT
dti-1301	114	26	it	it	PRON
dti-1301	114	27	seems	seem	VERB
dti-1301	114	28	to	to	PART
dti-1301	114	29	be	be	AUX
dti-1301	114	30	limited	limit	VERB
dti-1301	114	31	for	for	ADP
dti-1301	114	32	the	the	DET
dti-1301	114	33	delivery	delivery	NOUN
dti-1301	114	34	of	of	ADP
dti-1301	114	35	larger	large	ADJ
dti-1301	114	36	peptides	peptide	NOUN
dti-1301	114	37	or	or	CCONJ
dti-1301	114	38	macromolecules	macromolecule	NOUN
dti-1301	114	39	(	(	PUNCT
dti-1301	114	40	steffansen	steffansen	NOUN
dti-1301	114	41	et	et	PROPN
dti-1301	114	42	al	al	PROPN
dti-1301	114	43	.	.	PROPN
dti-1301	114	44	2005	2005	NUM
dti-1301	114	45	)	)	PUNCT
dti-1301	114	46	.	.	PUNCT
dti-1301	115	1	amino	amino	NOUN
dti-1301	115	2	acid	acid	PROPN
dti-1301	115	3	transporters	transporter	NOUN
dti-1301	115	4	amino	amino	NOUN
dti-1301	115	5	acid	acid	NOUN
dti-1301	115	6	transporters	transporter	NOUN
dti-1301	115	7	are	be	AUX
dti-1301	115	8	widely	widely	ADV
dti-1301	115	9	expressed	express	VERB
dti-1301	115	10	by	by	ADP
dti-1301	115	11	almost	almost	ADV
dti-1301	115	12	all	all	PRON
dti-1301	115	13	living	live	VERB
dti-1301	115	14	cells	cell	NOUN
dti-1301	115	15	and	and	CCONJ
dti-1301	115	16	are	be	AUX
dti-1301	115	17	responsible	responsible	ADJ
dti-1301	115	18	for	for	ADP
dti-1301	115	19	the	the	DET
dti-1301	115	20	absorption	absorption	NOUN
dti-1301	115	21	of	of	ADP
dti-1301	115	22	amino	amino	ADJ
dti-1301	115	23	acids	acid	NOUN
dti-1301	115	24	from	from	ADP
dti-1301	115	25	the	the	DET
dti-1301	115	26	gastrointestinal	gastrointestinal	ADJ
dti-1301	115	27	tract	tract	NOUN
dti-1301	115	28	into	into	ADP
dti-1301	115	29	the	the	DET
dti-1301	115	30	systemic	systemic	ADJ
dti-1301	115	31	circulation	circulation	NOUN
dti-1301	115	32	and	and	CCONJ
dti-1301	115	33	distribution	distribution	NOUN
dti-1301	115	34	into	into	ADP
dti-1301	115	35	tissues	tissue	NOUN
dti-1301	115	36	.	.	PUNCT
dti-1301	116	1	seven	seven	NUM
dti-1301	116	2	amino	amino	NOUN
dti-1301	116	3	acid	acid	NOUN
dti-1301	116	4	transport	transport	NOUN
dti-1301	116	5	systems	system	NOUN
dti-1301	116	6	have	have	AUX
dti-1301	116	7	been	be	AUX
dti-1301	116	8	identifi	identifi	PROPN
dti-1301	116	9	ed	ed	NOUN
dti-1301	116	10	in	in	ADP
dti-1301	116	11	the	the	DET
dti-1301	116	12	brush	brush	NOUN
dti-1301	116	13	border	border	NOUN
dti-1301	116	14	of	of	ADP
dti-1301	116	15	the	the	DET
dti-1301	116	16	small	small	ADJ
dti-1301	116	17	intestine	intestine	NOUN
dti-1301	116	18	of	of	ADP
dti-1301	116	19	which	which	PRON
dti-1301	116	20	some	some	DET
dti-1301	116	21	exhibit	exhibit	AUX
dti-1301	116	22	overlapping	overlap	VERB
dti-1301	116	23	substrate	substrate	NOUN
dti-1301	116	24	specifi	specifi	PROPN
dti-1301	116	25	cities	city	NOUN
dti-1301	116	26	(	(	PUNCT
dti-1301	116	27	hidalgo	hidalgo	PROPN
dti-1301	116	28	and	and	CCONJ
dti-1301	116	29	li	li	PROPN
dti-1301	116	30	,	,	PUNCT
dti-1301	116	31	1996	1996	NUM
dti-1301	116	32	)	)	PUNCT
dti-1301	116	33	.	.	PUNCT
dti-1301	117	1	these	these	DET
dti-1301	117	2	amino	amino	ADJ
dti-1301	117	3	acid	acid	NOUN
dti-1301	117	4	transporters	transporter	NOUN
dti-1301	117	5	present	present	VERB
dti-1301	117	6	a	a	DET
dti-1301	117	7	potential	potential	ADJ
dti-1301	117	8	target	target	NOUN
dti-1301	117	9	for	for	ADP
dti-1301	117	10	improving	improve	VERB
dti-1301	117	11	the	the	DET
dti-1301	117	12	absorption	absorption	NOUN
dti-1301	117	13	of	of	ADP
dti-1301	117	14	drugs	drug	NOUN
dti-1301	117	15	and	and	CCONJ
dti-1301	117	16	numerous	numerous	ADJ
dti-1301	117	17	studies	study	NOUN
dti-1301	117	18	have	have	AUX
dti-1301	117	19	investigated	investigate	VERB
dti-1301	117	20	the	the	DET
dti-1301	117	21	possibility	possibility	NOUN
dti-1301	117	22	of	of	ADP
dti-1301	117	23	targeting	target	VERB
dti-1301	117	24	pro	pro	ADJ
dti-1301	117	25	-	-	NOUN
dti-1301	117	26	drugs	drug	NOUN
dti-1301	117	27	and	and	CCONJ
dti-1301	117	28	derivatives	derivative	NOUN
dti-1301	117	29	to	to	PART
dti-1301	117	30	be	be	AUX
dti-1301	117	31	absorbed	absorb	VERB
dti-1301	117	32	via	via	ADP
dti-1301	117	33	these	these	DET
dti-1301	117	34	carriers	carrier	NOUN
dti-1301	117	35	.	.	PUNCT
dti-1301	118	1	the	the	DET
dti-1301	118	2	absorption	absorption	NOUN
dti-1301	118	3	of	of	ADP
dti-1301	118	4	gabapentin	gabapentin	NOUN
dti-1301	118	5	from	from	ADP
dti-1301	118	6	the	the	DET
dti-1301	118	7	small	small	ADJ
dti-1301	118	8	intestine	intestine	NOUN
dti-1301	118	9	,	,	PUNCT
dti-1301	118	10	for	for	ADP
dti-1301	118	11	example	example	NOUN
dti-1301	118	12	,	,	PUNCT
dti-1301	118	13	drug	drug	NOUN
dti-1301	118	14	target	target	NOUN
dti-1301	118	15	insights	insight	NOUN
dti-1301	118	16	2007	2007	NUM
dti-1301	118	17	:	:	PUNCT
dti-1301	118	18	276	276	NUM
dti-1301	118	19	hamman	hamman	PROPN
dti-1301	118	20	et	et	PROPN
dti-1301	118	21	al	al	PROPN
dti-1301	118	22	is	be	AUX
dti-1301	118	23	mediated	mediate	VERB
dti-1301	118	24	by	by	ADP
dti-1301	118	25	the	the	DET
dti-1301	118	26	large	large	ADJ
dti-1301	118	27	neutral	neutral	ADJ
dti-1301	118	28	amino	amino	NOUN
dti-1301	118	29	acid	acid	NOUN
dti-1301	118	30	transporter	transporter	NOUN
dti-1301	118	31	(	(	PUNCT
dti-1301	118	32	majumdar	majumdar	PROPN
dti-1301	118	33	and	and	CCONJ
dti-1301	118	34	mitra	mitra	PROPN
dti-1301	118	35	,	,	PUNCT
dti-1301	118	36	2006	2006	NUM
dti-1301	118	37	)	)	PUNCT
dti-1301	118	38	.	.	PUNCT
dti-1301	119	1	nucleoside	nucleoside	NOUN
dti-1301	119	2	transporters	transporter	NOUN
dti-1301	119	3	although	although	SCONJ
dti-1301	119	4	nucleosides	nucleoside	NOUN
dti-1301	119	5	and	and	CCONJ
dti-1301	119	6	nucleotides	nucleotide	NOUN
dti-1301	119	7	are	be	AUX
dti-1301	119	8	essential	essential	ADJ
dti-1301	119	9	precursors	precursor	NOUN
dti-1301	119	10	for	for	ADP
dti-1301	119	11	the	the	DET
dti-1301	119	12	synthesis	synthesis	NOUN
dti-1301	119	13	of	of	ADP
dti-1301	119	14	nucleic	nucleic	ADJ
dti-1301	119	15	acids	acid	NOUN
dti-1301	119	16	,	,	PUNCT
dti-1301	119	17	they	they	PRON
dti-1301	119	18	are	be	AUX
dti-1301	119	19	not	not	PART
dti-1301	119	20	required	require	VERB
dti-1301	119	21	to	to	PART
dti-1301	119	22	be	be	AUX
dti-1301	119	23	taken	take	VERB
dti-1301	119	24	up	up	ADP
dti-1301	119	25	by	by	ADP
dti-1301	119	26	most	most	ADJ
dti-1301	119	27	cells	cell	NOUN
dti-1301	119	28	because	because	SCONJ
dti-1301	119	29	these	these	DET
dti-1301	119	30	compounds	compound	NOUN
dti-1301	119	31	are	be	AUX
dti-1301	119	32	synthesized	synthesize	VERB
dti-1301	119	33	intracellularly	intracellularly	ADV
dti-1301	119	34	.	.	PUNCT
dti-1301	120	1	however	however	ADV
dti-1301	120	2	,	,	PUNCT
dti-1301	120	3	the	the	DET
dti-1301	120	4	synthesis	synthesis	NOUN
dti-1301	120	5	of	of	ADP
dti-1301	120	6	purines	purine	NOUN
dti-1301	120	7	and	and	CCONJ
dti-1301	120	8	pyrimidines	pyrimidine	NOUN
dti-1301	120	9	in	in	ADP
dti-1301	120	10	enterocytes	enterocyte	NOUN
dti-1301	120	11	is	be	AUX
dti-1301	120	12	insufficient	insufficient	ADJ
dti-1301	120	13	to	to	PART
dti-1301	120	14	support	support	VERB
dti-1301	120	15	their	their	PRON
dti-1301	120	16	rapid	rapid	ADJ
dti-1301	120	17	division	division	NOUN
dti-1301	120	18	.	.	PUNCT
dti-1301	121	1	these	these	DET
dti-1301	121	2	building	building	NOUN
dti-1301	121	3	blocks	block	NOUN
dti-1301	121	4	of	of	ADP
dti-1301	121	5	nucleic	nucleic	ADJ
dti-1301	121	6	acids	acid	NOUN
dti-1301	121	7	are	be	AUX
dti-1301	121	8	therefore	therefore	ADV
dti-1301	121	9	absorbed	absorb	VERB
dti-1301	121	10	from	from	ADP
dti-1301	121	11	the	the	DET
dti-1301	121	12	intestinal	intestinal	ADJ
dti-1301	121	13	lumen	luman	NOUN
dti-1301	121	14	through	through	ADP
dti-1301	121	15	equilibrative	equilibrative	ADJ
dti-1301	121	16	(	(	PUNCT
dti-1301	121	17	facilitated	facilitated	ADJ
dti-1301	121	18	diffusion	diffusion	NOUN
dti-1301	121	19	)	)	PUNCT
dti-1301	121	20	transport	transport	NOUN
dti-1301	121	21	systems	system	NOUN
dti-1301	121	22	and	and	CCONJ
dti-1301	121	23	na+-dependent	na+-dependent	NUM
dti-1301	121	24	concentrative	concentrative	ADJ
dti-1301	121	25	(	(	PUNCT
dti-1301	121	26	energy	energy	NOUN
dti-1301	121	27	-	-	PUNCT
dti-1301	121	28	dependent	dependent	ADJ
dti-1301	121	29	active	active	ADJ
dti-1301	121	30	transport	transport	NOUN
dti-1301	121	31	)	)	PUNCT
dti-1301	121	32	mechanisms	mechanism	NOUN
dti-1301	121	33	(	(	PUNCT
dti-1301	121	34	hidalgo	hidalgo	PROPN
dti-1301	121	35	and	and	CCONJ
dti-1301	121	36	li	li	PROPN
dti-1301	121	37	,	,	PUNCT
dti-1301	121	38	1996	1996	NUM
dti-1301	121	39	;	;	PUNCT
dti-1301	121	40	lee	lee	PROPN
dti-1301	121	41	,	,	PUNCT
dti-1301	121	42	2000	2000	NUM
dti-1301	121	43	)	)	PUNCT
dti-1301	121	44	.	.	PUNCT
dti-1301	122	1	examples	example	NOUN
dti-1301	122	2	of	of	ADP
dti-1301	122	3	drugs	drug	NOUN
dti-1301	122	4	that	that	PRON
dti-1301	122	5	are	be	AUX
dti-1301	122	6	absorbed	absorb	VERB
dti-1301	122	7	by	by	ADP
dti-1301	122	8	equilibrative	equilibrative	ADJ
dti-1301	122	9	nucleoside	nucleoside	NOUN
dti-1301	122	10	transporters	transporter	NOUN
dti-1301	122	11	include	include	VERB
dti-1301	122	12	s	s	NOUN
dti-1301	122	13	-	-	NOUN
dti-1301	122	14	adneosylmethionine	adneosylmethionine	NOUN
dti-1301	122	15	,	,	PUNCT
dti-1301	122	16	fludarabine	fludarabine	PROPN
dti-1301	122	17	,	,	PUNCT
dti-1301	122	18	arabinosylcytosine	arabinosylcytosine	NOUN
dti-1301	122	19	and	and	CCONJ
dti-1301	122	20	azidothymidine	azidothymidine	NOUN
dti-1301	122	21	(	(	PUNCT
dti-1301	122	22	majumdar	majumdar	PROPN
dti-1301	122	23	et	et	PROPN
dti-1301	122	24	al	al	PROPN
dti-1301	122	25	.	.	PROPN
dti-1301	122	26	2004	2004	NUM
dti-1301	122	27	)	)	PUNCT
dti-1301	122	28	.	.	PUNCT
dti-1301	123	1	bile	bile	NOUN
dti-1301	123	2	acid	acid	NOUN
dti-1301	123	3	transporters	transporter	NOUN
dti-1301	123	4	bile	bile	NOUN
dti-1301	123	5	acids	acid	NOUN
dti-1301	123	6	are	be	AUX
dti-1301	123	7	synthesized	synthesize	VERB
dti-1301	123	8	in	in	ADP
dti-1301	123	9	the	the	DET
dti-1301	123	10	liver	liver	NOUN
dti-1301	123	11	and	and	CCONJ
dti-1301	123	12	secreted	secrete	VERB
dti-1301	123	13	into	into	ADP
dti-1301	123	14	the	the	DET
dti-1301	123	15	duodenum	duodenum	NOUN
dti-1301	123	16	after	after	ADP
dti-1301	123	17	ingestion	ingestion	NOUN
dti-1301	123	18	of	of	ADP
dti-1301	123	19	a	a	DET
dti-1301	123	20	meal	meal	NOUN
dti-1301	123	21	,	,	PUNCT
dti-1301	123	22	to	to	PART
dti-1301	123	23	facilitate	facilitate	VERB
dti-1301	123	24	the	the	DET
dti-1301	123	25	digestion	digestion	NOUN
dti-1301	123	26	and	and	CCONJ
dti-1301	123	27	absorption	absorption	NOUN
dti-1301	123	28	of	of	ADP
dti-1301	123	29	fats	fat	NOUN
dti-1301	123	30	.	.	PUNCT
dti-1301	124	1	approximately	approximately	ADV
dti-1301	124	2	90	90	NUM
dti-1301	124	3	%	%	NOUN
dti-1301	124	4	of	of	ADP
dti-1301	124	5	the	the	DET
dti-1301	124	6	bile	bile	NOUN
dti-1301	124	7	acids	acid	NOUN
dti-1301	124	8	that	that	PRON
dti-1301	124	9	are	be	AUX
dti-1301	124	10	secreted	secrete	VERB
dti-1301	124	11	into	into	ADP
dti-1301	124	12	the	the	DET
dti-1301	124	13	small	small	ADJ
dti-1301	124	14	intestinal	intestinal	ADJ
dti-1301	124	15	lumen	luman	NOUN
dti-1301	124	16	are	be	AUX
dti-1301	124	17	recycled	recycle	VERB
dti-1301	124	18	back	back	ADV
dti-1301	124	19	to	to	ADP
dti-1301	124	20	the	the	DET
dti-1301	124	21	liver	liver	NOUN
dti-1301	124	22	to	to	PART
dti-1301	124	23	prevent	prevent	VERB
dti-1301	124	24	the	the	DET
dti-1301	124	25	continuous	continuous	ADJ
dti-1301	124	26	re	re	NOUN
dti-1301	124	27	-	-	NOUN
dti-1301	124	28	synthesis	synthesis	NOUN
dti-1301	124	29	of	of	ADP
dti-1301	124	30	large	large	ADJ
dti-1301	124	31	amounts	amount	NOUN
dti-1301	124	32	of	of	ADP
dti-1301	124	33	bile	bile	NOUN
dti-1301	124	34	acids	acid	NOUN
dti-1301	124	35	.	.	PUNCT
dti-1301	125	1	re	re	NOUN
dti-1301	125	2	-	-	NOUN
dti-1301	125	3	absorption	absorption	NOUN
dti-1301	125	4	of	of	ADP
dti-1301	125	5	bile	bile	NOUN
dti-1301	125	6	acids	acid	NOUN
dti-1301	125	7	occurs	occur	VERB
dti-1301	125	8	by	by	ADP
dti-1301	125	9	passive	passive	ADJ
dti-1301	125	10	diffusion	diffusion	NOUN
dti-1301	125	11	in	in	ADP
dti-1301	125	12	the	the	DET
dti-1301	125	13	jejunum	jejunum	NOUN
dti-1301	125	14	,	,	PUNCT
dti-1301	125	15	but	but	CCONJ
dti-1301	125	16	by	by	ADP
dti-1301	125	17	active	active	ADJ
dti-1301	125	18	transport	transport	NOUN
dti-1301	125	19	in	in	ADP
dti-1301	125	20	the	the	DET
dti-1301	125	21	ileum	ileum	NOUN
dti-1301	125	22	.	.	PUNCT
dti-1301	126	1	the	the	DET
dti-1301	126	2	na+	na+	NOUN
dti-1301	126	3	-dependent	-dependent	ADJ
dti-1301	126	4	bile	bile	NOUN
dti-1301	126	5	acid	acid	NOUN
dti-1301	126	6	active	active	ADJ
dti-1301	126	7	transport	transport	NOUN
dti-1301	126	8	carriers	carrier	NOUN
dti-1301	126	9	are	be	AUX
dti-1301	126	10	located	locate	VERB
dti-1301	126	11	in	in	ADP
dti-1301	126	12	the	the	DET
dti-1301	126	13	apical	apical	ADJ
dti-1301	126	14	membrane	membrane	NOUN
dti-1301	126	15	of	of	ADP
dti-1301	126	16	the	the	DET
dti-1301	126	17	epithelial	epithelial	ADJ
dti-1301	126	18	cells	cell	NOUN
dti-1301	126	19	of	of	ADP
dti-1301	126	20	the	the	DET
dti-1301	126	21	ileum	ileum	NOUN
dti-1301	126	22	and	and	CCONJ
dti-1301	126	23	the	the	DET
dti-1301	126	24	na+	na+	NOUN
dti-1301	126	25	gradient	gradient	NOUN
dti-1301	126	26	required	require	VERB
dti-1301	126	27	is	be	AUX
dti-1301	126	28	provided	provide	VERB
dti-1301	126	29	by	by	ADP
dti-1301	126	30	na+	na+	NOUN
dti-1301	126	31	/k+	/k+	PUNCT
dti-1301	127	1	atpase	atpase	PROPN
dti-1301	127	2	located	locate	VERB
dti-1301	127	3	in	in	ADP
dti-1301	127	4	the	the	DET
dti-1301	127	5	basolateral	basolateral	ADJ
dti-1301	127	6	cell	cell	NOUN
dti-1301	127	7	membrane	membrane	NOUN
dti-1301	127	8	.	.	PUNCT
dti-1301	128	1	the	the	DET
dti-1301	128	2	strategy	strategy	NOUN
dti-1301	128	3	to	to	PART
dti-1301	128	4	enhance	enhance	VERB
dti-1301	128	5	drug	drug	NOUN
dti-1301	128	6	absorption	absorption	NOUN
dti-1301	128	7	via	via	ADP
dti-1301	128	8	this	this	DET
dti-1301	128	9	active	active	ADJ
dti-1301	128	10	transporter	transporter	NOUN
dti-1301	128	11	system	system	NOUN
dti-1301	128	12	involves	involve	VERB
dti-1301	128	13	formation	formation	NOUN
dti-1301	128	14	of	of	ADP
dti-1301	128	15	bile	bile	NOUN
dti-1301	128	16	acid	acid	NOUN
dti-1301	128	17	-	-	PUNCT
dti-1301	128	18	drug	drug	NOUN
dti-1301	128	19	conjugates	conjugate	NOUN
dti-1301	128	20	.	.	PUNCT
dti-1301	129	1	it	it	PRON
dti-1301	129	2	was	be	AUX
dti-1301	129	3	shown	show	VERB
dti-1301	129	4	that	that	SCONJ
dti-1301	129	5	the	the	DET
dti-1301	129	6	size	size	NOUN
dti-1301	129	7	of	of	ADP
dti-1301	129	8	the	the	DET
dti-1301	129	9	molecule	molecule	NOUN
dti-1301	129	10	conjugated	conjugate	VERB
dti-1301	129	11	to	to	ADP
dti-1301	129	12	the	the	DET
dti-1301	129	13	bile	bile	NOUN
dti-1301	129	14	acid	acid	NOUN
dti-1301	129	15	plays	play	VERB
dti-1301	129	16	an	an	DET
dti-1301	129	17	important	important	ADJ
dti-1301	129	18	role	role	NOUN
dti-1301	129	19	in	in	ADP
dti-1301	129	20	its	its	PRON
dti-1301	129	21	ability	ability	NOUN
dti-1301	129	22	to	to	PART
dti-1301	129	23	be	be	AUX
dti-1301	129	24	absorbed	absorb	VERB
dti-1301	129	25	via	via	ADP
dti-1301	129	26	the	the	DET
dti-1301	129	27	bile	bile	NOUN
dti-1301	129	28	acid	acid	NOUN
dti-1301	129	29	transporters	transporter	NOUN
dti-1301	129	30	.	.	PUNCT
dti-1301	130	1	another	another	DET
dti-1301	130	2	challenge	challenge	NOUN
dti-1301	130	3	to	to	PART
dti-1301	130	4	be	be	AUX
dti-1301	130	5	overcome	overcome	VERB
dti-1301	130	6	,	,	PUNCT
dti-1301	130	7	before	before	SCONJ
dti-1301	130	8	this	this	DET
dti-1301	130	9	strategy	strategy	NOUN
dti-1301	130	10	can	can	AUX
dti-1301	130	11	be	be	AUX
dti-1301	130	12	used	use	VERB
dti-1301	130	13	for	for	ADP
dti-1301	130	14	drug	drug	NOUN
dti-1301	130	15	absorption	absorption	NOUN
dti-1301	130	16	,	,	PUNCT
dti-1301	130	17	is	be	AUX
dti-1301	130	18	to	to	PART
dti-1301	130	19	avoid	avoid	VERB
dti-1301	130	20	biliary	biliary	ADJ
dti-1301	130	21	secretion	secretion	NOUN
dti-1301	130	22	of	of	ADP
dti-1301	130	23	the	the	DET
dti-1301	130	24	conjugates	conjugate	NOUN
dti-1301	130	25	back	back	ADV
dti-1301	130	26	into	into	ADP
dti-1301	130	27	the	the	DET
dti-1301	130	28	gastrointestinal	gastrointestinal	ADJ
dti-1301	130	29	lumen	luman	NOUN
dti-1301	130	30	.	.	PUNCT
dti-1301	131	1	it	it	PRON
dti-1301	131	2	seems	seem	VERB
dti-1301	131	3	that	that	SCONJ
dti-1301	131	4	if	if	SCONJ
dti-1301	131	5	the	the	DET
dti-1301	131	6	drug	drug	NOUN
dti-1301	131	7	is	be	AUX
dti-1301	131	8	not	not	PART
dti-1301	131	9	released	release	VERB
dti-1301	131	10	from	from	ADP
dti-1301	131	11	the	the	DET
dti-1301	131	12	conjugate	conjugate	NOUN
dti-1301	131	13	before	before	ADP
dti-1301	131	14	reaching	reach	VERB
dti-1301	131	15	the	the	DET
dti-1301	131	16	liver	liver	NOUN
dti-1301	131	17	,	,	PUNCT
dti-1301	131	18	it	it	PRON
dti-1301	131	19	will	will	AUX
dti-1301	131	20	most	most	ADV
dti-1301	131	21	probably	probably	ADV
dti-1301	131	22	be	be	AUX
dti-1301	131	23	secreted	secrete	VERB
dti-1301	131	24	into	into	ADP
dti-1301	131	25	the	the	DET
dti-1301	131	26	bile	bile	NOUN
dti-1301	131	27	(	(	PUNCT
dti-1301	131	28	hidalgo	hidalgo	PROPN
dti-1301	131	29	and	and	CCONJ
dti-1301	131	30	li	li	PROPN
dti-1301	131	31	,	,	PUNCT
dti-1301	131	32	1996	1996	NUM
dti-1301	131	33	)	)	PUNCT
dti-1301	131	34	.	.	PUNCT
dti-1301	132	1	monocarboxylic	monocarboxylic	ADJ
dti-1301	132	2	acid	acid	PROPN
dti-1301	132	3	transporters	transporter	NOUN
dti-1301	132	4	the	the	DET
dti-1301	132	5	transport	transport	NOUN
dti-1301	132	6	of	of	ADP
dti-1301	132	7	lactic	lactic	ADJ
dti-1301	132	8	acid	acid	NOUN
dti-1301	132	9	,	,	PUNCT
dti-1301	132	10	which	which	PRON
dti-1301	132	11	is	be	AUX
dti-1301	132	12	produced	produce	VERB
dti-1301	132	13	during	during	ADP
dti-1301	132	14	the	the	DET
dti-1301	132	15	metabolic	metabolic	NOUN
dti-1301	132	16	reactions	reaction	NOUN
dti-1301	132	17	to	to	PART
dti-1301	132	18	generate	generate	VERB
dti-1301	132	19	atp	atp	PROPN
dti-1301	132	20	,	,	PUNCT
dti-1301	132	21	into	into	ADP
dti-1301	132	22	and	and	CCONJ
dti-1301	132	23	out	out	ADP
dti-1301	132	24	of	of	ADP
dti-1301	132	25	cells	cell	NOUN
dti-1301	132	26	is	be	AUX
dti-1301	132	27	mediated	mediate	VERB
dti-1301	132	28	by	by	ADP
dti-1301	132	29	h+	h+	PUNCT
dti-1301	132	30	-dependent	-dependent	ADJ
dti-1301	132	31	monocarboxylic	monocarboxylic	ADJ
dti-1301	132	32	acid	acid	NOUN
dti-1301	132	33	transporter	transporter	NOUN
dti-1301	132	34	family	family	NOUN
dti-1301	132	35	.	.	PUNCT
dti-1301	133	1	in	in	ADP
dti-1301	133	2	addition	addition	NOUN
dti-1301	133	3	,	,	PUNCT
dti-1301	133	4	monocarboxylate	monocarboxylate	ADJ
dti-1301	133	5	drugs	drug	NOUN
dti-1301	133	6	such	such	ADJ
dti-1301	133	7	as	as	ADP
dti-1301	133	8	valproic	valproic	ADJ
dti-1301	133	9	acid	acid	NOUN
dti-1301	133	10	,	,	PUNCT
dti-1301	133	11	salicylic	salicylic	ADJ
dti-1301	133	12	acid	acid	NOUN
dti-1301	133	13	and	and	CCONJ
dti-1301	133	14	pravastatin	pravastatin	NOUN
dti-1301	133	15	have	have	AUX
dti-1301	133	16	been	be	AUX
dti-1301	133	17	shown	show	VERB
dti-1301	133	18	to	to	PART
dti-1301	133	19	be	be	AUX
dti-1301	133	20	transported	transport	VERB
dti-1301	133	21	by	by	ADP
dti-1301	133	22	monocarboxylic	monocarboxylic	ADJ
dti-1301	133	23	acid	acid	NOUN
dti-1301	133	24	transporters	transporter	NOUN
dti-1301	133	25	in	in	ADP
dti-1301	133	26	the	the	DET
dti-1301	133	27	intestine	intestine	NOUN
dti-1301	133	28	.	.	PUNCT
dti-1301	134	1	however	however	ADV
dti-1301	134	2	,	,	PUNCT
dti-1301	134	3	because	because	SCONJ
dti-1301	134	4	the	the	DET
dti-1301	134	5	retinal	retinal	ADJ
dti-1301	134	6	pigmented	pigmented	ADJ
dti-1301	134	7	epithelium	epithelium	NOUN
dti-1301	134	8	expresses	express	VERB
dti-1301	134	9	a	a	DET
dti-1301	134	10	monocarboxylic	monocarboxylic	ADJ
dti-1301	134	11	acid	acid	NOUN
dti-1301	134	12	transporter	transporter	NOUN
dti-1301	134	13	,	,	PUNCT
dti-1301	134	14	pro	pro	ADJ
dti-1301	134	15	-	-	ADJ
dti-1301	134	16	drugs	drug	NOUN
dti-1301	134	17	targeted	target	VERB
dti-1301	134	18	at	at	ADP
dti-1301	134	19	these	these	DET
dti-1301	134	20	transporters	transporter	NOUN
dti-1301	134	21	may	may	AUX
dti-1301	134	22	be	be	AUX
dti-1301	134	23	useful	useful	ADJ
dti-1301	134	24	in	in	ADP
dti-1301	134	25	enhanced	enhanced	ADJ
dti-1301	134	26	retinal	retinal	ADJ
dti-1301	134	27	drug	drug	NOUN
dti-1301	134	28	permeation	permeation	NOUN
dti-1301	134	29	to	to	PART
dti-1301	134	30	achieve	achieve	VERB
dti-1301	134	31	higher	high	ADJ
dti-1301	134	32	drug	drug	NOUN
dti-1301	134	33	concentrations	concentration	NOUN
dti-1301	134	34	in	in	ADP
dti-1301	134	35	the	the	DET
dti-1301	134	36	deeper	deep	ADJ
dti-1301	134	37	layers	layer	NOUN
dti-1301	134	38	of	of	ADP
dti-1301	134	39	the	the	DET
dti-1301	134	40	cornea	cornea	NOUN
dti-1301	134	41	and	and	CCONJ
dti-1301	134	42	aqueous	aqueous	ADJ
dti-1301	134	43	humor	humor	NOUN
dti-1301	134	44	(	(	PUNCT
dti-1301	134	45	lee	lee	PROPN
dti-1301	134	46	,	,	PUNCT
dti-1301	134	47	2000	2000	NUM
dti-1301	134	48	;	;	PUNCT
dti-1301	134	49	majumdar	majumdar	PROPN
dti-1301	134	50	et	et	PROPN
dti-1301	134	51	al	al	PROPN
dti-1301	134	52	.	.	PROPN
dti-1301	134	53	2004	2004	NUM
dti-1301	134	54	)	)	PUNCT
dti-1301	134	55	.	.	PUNCT
dti-1301	135	1	miscellaneous	miscellaneous	ADJ
dti-1301	135	2	(	(	PUNCT
dti-1301	135	3	glucose	glucose	NOUN
dti-1301	135	4	,	,	PUNCT
dti-1301	135	5	fatty	fatty	NOUN
dti-1301	135	6	acid	acid	NOUN
dti-1301	135	7	,	,	PUNCT
dti-1301	135	8	vitamin	vitamin	NOUN
dti-1301	135	9	,	,	PUNCT
dti-1301	135	10	organic	organic	ADJ
dti-1301	135	11	cation	cation	NOUN
dti-1301	135	12	and	and	CCONJ
dti-1301	135	13	phosphate	phosphate	ADJ
dti-1301	135	14	)	)	PUNCT
dti-1301	135	15	transporters	transporter	NOUN
dti-1301	135	16	two	two	NUM
dti-1301	135	17	types	type	NOUN
dti-1301	135	18	of	of	ADP
dti-1301	135	19	transporters	transporter	NOUN
dti-1301	135	20	exist	exist	VERB
dti-1301	135	21	for	for	ADP
dti-1301	135	22	the	the	DET
dti-1301	135	23	transport	transport	NOUN
dti-1301	135	24	of	of	ADP
dti-1301	135	25	monosaccharides	monosaccharide	NOUN
dti-1301	135	26	across	across	ADP
dti-1301	135	27	biological	biological	ADJ
dti-1301	135	28	membranes	membrane	NOUN
dti-1301	135	29	,	,	PUNCT
dti-1301	135	30	these	these	PRON
dti-1301	135	31	include	include	VERB
dti-1301	135	32	the	the	DET
dti-1301	135	33	sodium	sodium	NOUN
dti-1301	135	34	-	-	PUNCT
dti-1301	135	35	dependent	dependent	ADJ
dti-1301	135	36	na+/glucose	na+/glucose	VERB
dti-1301	135	37	co	co	NOUN
dti-1301	135	38	-	-	NOUN
dti-1301	135	39	transporters	transporter	NOUN
dti-1301	135	40	(	(	PUNCT
dti-1301	135	41	sglt	sglt	ADJ
dti-1301	135	42	)	)	PUNCT
dti-1301	135	43	and	and	CCONJ
dti-1301	135	44	sodium	sodium	NOUN
dti-1301	135	45	-	-	PUNCT
dti-1301	135	46	independent	independent	ADJ
dti-1301	135	47	glucose	glucose	NOUN
dti-1301	135	48	transporters	transporter	NOUN
dti-1301	135	49	(	(	PUNCT
dti-1301	135	50	glut	glut	PROPN
dti-1301	135	51	)	)	PUNCT
dti-1301	135	52	.	.	PUNCT
dti-1301	136	1	because	because	SCONJ
dti-1301	136	2	sglt1	sglt1	PROPN
dti-1301	136	3	exhibits	exhibit	VERB
dti-1301	136	4	a	a	DET
dti-1301	136	5	high	high	ADJ
dti-1301	136	6	capacity	capacity	NOUN
dti-1301	136	7	and	and	CCONJ
dti-1301	136	8	broad	broad	ADJ
dti-1301	136	9	substrate	substrate	NOUN
dti-1301	136	10	specificity	specificity	NOUN
dti-1301	136	11	,	,	PUNCT
dti-1301	136	12	targeting	target	VERB
dti-1301	136	13	this	this	DET
dti-1301	136	14	receptor	receptor	NOUN
dti-1301	136	15	for	for	ADP
dti-1301	136	16	drug	drug	NOUN
dti-1301	136	17	delivery	delivery	NOUN
dti-1301	136	18	offers	offer	VERB
dti-1301	136	19	an	an	DET
dti-1301	136	20	exciting	exciting	ADJ
dti-1301	136	21	opportunity	opportunity	NOUN
dti-1301	136	22	to	to	PART
dti-1301	136	23	improve	improve	VERB
dti-1301	136	24	the	the	DET
dti-1301	136	25	bioavailability	bioavailability	NOUN
dti-1301	136	26	of	of	ADP
dti-1301	136	27	drugs	drug	NOUN
dti-1301	136	28	(	(	PUNCT
dti-1301	136	29	steffansen	steffansen	NOUN
dti-1301	136	30	et	et	PROPN
dti-1301	136	31	al	al	PROPN
dti-1301	136	32	.	.	PROPN
dti-1301	136	33	2004	2004	NUM
dti-1301	136	34	)	)	PUNCT
dti-1301	136	35	.	.	PUNCT
dti-1301	137	1	three	three	NUM
dti-1301	137	2	types	type	NOUN
dti-1301	137	3	of	of	ADP
dti-1301	137	4	fatty	fatty	NOUN
dti-1301	137	5	acid	acid	NOUN
dti-1301	137	6	transporter	transporter	NOUN
dti-1301	137	7	proteins	protein	NOUN
dti-1301	137	8	have	have	AUX
dti-1301	137	9	been	be	AUX
dti-1301	137	10	identifi	identifi	PROPN
dti-1301	137	11	ed	ed	NOUN
dti-1301	137	12	of	of	ADP
dti-1301	137	13	which	which	PRON
dti-1301	137	14	fatp4	fatp4	NOUN
dti-1301	137	15	is	be	AUX
dti-1301	137	16	located	locate	VERB
dti-1301	137	17	in	in	ADP
dti-1301	137	18	the	the	DET
dti-1301	137	19	apical	apical	ADJ
dti-1301	137	20	membrane	membrane	NOUN
dti-1301	137	21	of	of	ADP
dti-1301	137	22	the	the	DET
dti-1301	137	23	small	small	ADJ
dti-1301	137	24	intestine	intestine	NOUN
dti-1301	137	25	with	with	ADP
dti-1301	137	26	long	long	ADJ
dti-1301	137	27	chain	chain	NOUN
dti-1301	137	28	fatty	fatty	NOUN
dti-1301	137	29	acids	acid	NOUN
dti-1301	137	30	as	as	ADP
dti-1301	137	31	substrates	substrate	NOUN
dti-1301	137	32	(	(	PUNCT
dti-1301	137	33	e.g.	e.g.	ADV
dti-1301	137	34	myristate	myristate	ADJ
dti-1301	137	35	,	,	PUNCT
dti-1301	137	36	oleate	oleate	ADJ
dti-1301	137	37	and	and	CCONJ
dti-1301	137	38	palmitate	palmitate	NOUN
dti-1301	137	39	)	)	PUNCT
dti-1301	137	40	.	.	PUNCT
dti-1301	138	1	not	not	PART
dti-1301	138	2	much	much	ADJ
dti-1301	138	3	information	information	NOUN
dti-1301	138	4	is	be	AUX
dti-1301	138	5	currently	currently	ADV
dti-1301	138	6	available	available	ADJ
dti-1301	138	7	on	on	ADP
dti-1301	138	8	these	these	DET
dti-1301	138	9	transporters	transporter	NOUN
dti-1301	138	10	and	and	CCONJ
dti-1301	138	11	further	further	ADJ
dti-1301	138	12	investigation	investigation	NOUN
dti-1301	138	13	is	be	AUX
dti-1301	138	14	needed	need	VERB
dti-1301	138	15	to	to	PART
dti-1301	138	16	determine	determine	VERB
dti-1301	138	17	their	their	PRON
dti-1301	138	18	usefulness	usefulness	NOUN
dti-1301	138	19	in	in	ADP
dti-1301	138	20	drug	drug	NOUN
dti-1301	138	21	delivery	delivery	NOUN
dti-1301	138	22	(	(	PUNCT
dti-1301	138	23	steffansen	steffansen	NOUN
dti-1301	138	24	et	et	PROPN
dti-1301	138	25	al	al	PROPN
dti-1301	138	26	.	.	PROPN
dti-1301	138	27	2004	2004	NUM
dti-1301	138	28	)	)	PUNCT
dti-1301	138	29	.	.	PUNCT
dti-1301	139	1	although	although	SCONJ
dti-1301	139	2	transporters	transporter	NOUN
dti-1301	139	3	for	for	ADP
dti-1301	139	4	uptake	uptake	NOUN
dti-1301	139	5	of	of	ADP
dti-1301	139	6	watersoluble	watersoluble	ADJ
dti-1301	139	7	vitamins	vitamin	NOUN
dti-1301	139	8	are	be	AUX
dti-1301	139	9	expressed	express	VERB
dti-1301	139	10	in	in	ADP
dti-1301	139	11	the	the	DET
dti-1301	139	12	intestine	intestine	NOUN
dti-1301	139	13	such	such	ADJ
dti-1301	139	14	as	as	ADP
dti-1301	139	15	those	those	PRON
dti-1301	139	16	for	for	ADP
dti-1301	139	17	vitamin	vitamin	NOUN
dti-1301	139	18	c	c	NOUN
dti-1301	139	19	(	(	PUNCT
dti-1301	139	20	ascorbic	ascorbic	NOUN
dti-1301	139	21	acid	acid	NOUN
dti-1301	139	22	)	)	PUNCT
dti-1301	139	23	and	and	CCONJ
dti-1301	139	24	biotin	biotin	NOUN
dti-1301	139	25	,	,	PUNCT
dti-1301	139	26	their	their	PRON
dti-1301	139	27	general	general	ADJ
dti-1301	139	28	low	low	ADJ
dti-1301	139	29	capacities	capacity	NOUN
dti-1301	139	30	make	make	VERB
dti-1301	139	31	them	they	PRON
dti-1301	139	32	poor	poor	ADJ
dti-1301	139	33	transporter	transporter	NOUN
dti-1301	139	34	candidates	candidate	NOUN
dti-1301	139	35	to	to	PART
dti-1301	139	36	target	target	VERB
dti-1301	139	37	for	for	ADP
dti-1301	139	38	enhancement	enhancement	NOUN
dti-1301	139	39	of	of	ADP
dti-1301	139	40	drug	drug	NOUN
dti-1301	139	41	absorption	absorption	NOUN
dti-1301	139	42	(	(	PUNCT
dti-1301	139	43	steffansen	steffansen	NOUN
dti-1301	139	44	et	et	PROPN
dti-1301	139	45	al	al	PROPN
dti-1301	139	46	.	.	PROPN
dti-1301	139	47	2004	2004	NUM
dti-1301	139	48	)	)	PUNCT
dti-1301	139	49	.	.	PUNCT
dti-1301	140	1	many	many	ADJ
dti-1301	140	2	drugs	drug	NOUN
dti-1301	140	3	that	that	PRON
dti-1301	140	4	carry	carry	VERB
dti-1301	140	5	a	a	DET
dti-1301	140	6	positive	positive	ADJ
dti-1301	140	7	charge	charge	NOUN
dti-1301	140	8	at	at	ADP
dti-1301	140	9	physiological	physiological	ADJ
dti-1301	140	10	ph	ph	NOUN
dti-1301	140	11	values	value	NOUN
dti-1301	140	12	(	(	PUNCT
dti-1301	140	13	e.g.	e.g.	ADV
dti-1301	140	14	antihistamines	antihistamine	NOUN
dti-1301	140	15	)	)	PUNCT
dti-1301	140	16	are	be	AUX
dti-1301	140	17	transported	transport	VERB
dti-1301	140	18	by	by	ADP
dti-1301	140	19	the	the	DET
dti-1301	140	20	organic	organic	ADJ
dti-1301	140	21	cation	cation	NOUN
dti-1301	140	22	transporters	transporter	NOUN
dti-1301	140	23	.	.	PUNCT
dti-1301	141	1	phosphate	phosphate	ADJ
dti-1301	141	2	transporters	transporter	NOUN
dti-1301	141	3	hold	hold	VERB
dti-1301	141	4	some	some	DET
dti-1301	141	5	potential	potential	NOUN
dti-1301	141	6	for	for	ADP
dti-1301	141	7	the	the	DET
dti-1301	141	8	delivery	delivery	NOUN
dti-1301	141	9	of	of	ADP
dti-1301	141	10	drugs	drug	NOUN
dti-1301	141	11	and	and	CCONJ
dti-1301	141	12	fosfomycin	fosfomycin	VERB
dti-1301	141	13	as	as	ADV
dti-1301	141	14	well	well	ADV
dti-1301	141	15	as	as	ADP
dti-1301	141	16	foscarnet	foscarnet	NOUN
dti-1301	141	17	have	have	AUX
dti-1301	141	18	been	be	AUX
dti-1301	141	19	shown	show	VERB
dti-1301	141	20	to	to	PART
dti-1301	141	21	be	be	AUX
dti-1301	141	22	substrates	substrate	NOUN
dti-1301	141	23	for	for	ADP
dti-1301	141	24	these	these	DET
dti-1301	141	25	transport	transport	NOUN
dti-1301	141	26	carrier	carrier	NOUN
dti-1301	141	27	systems	system	NOUN
dti-1301	141	28	(	(	PUNCT
dti-1301	141	29	majumdar	majumdar	PROPN
dti-1301	141	30	et	et	PROPN
dti-1301	141	31	al	al	PROPN
dti-1301	141	32	.	.	PROPN
dti-1301	141	33	2004	2004	NUM
dti-1301	141	34	)	)	PUNCT
dti-1301	141	35	.	.	PUNCT
dti-1301	142	1	drug	drug	NOUN
dti-1301	142	2	target	target	NOUN
dti-1301	142	3	insights	insight	NOUN
dti-1301	142	4	2007	2007	NUM
dti-1301	142	5	:	:	PUNCT
dti-1301	142	6	2	2	NUM
dti-1301	142	7	77	77	NUM
dti-1301	142	8	targeted	target	VERB
dti-1301	142	9	oral	oral	ADJ
dti-1301	142	10	drug	drug	NOUN
dti-1301	142	11	delivery	delivery	NOUN
dti-1301	142	12	p	p	NOUN
dti-1301	142	13	-	-	PUNCT
dti-1301	142	14	glycoprotein	glycoprotein	NOUN
dti-1301	142	15	effl	effl	NOUN
dti-1301	142	16	ux	ux	PROPN
dti-1301	142	17	transporters	transporter	NOUN
dti-1301	142	18	p	p	NOUN
dti-1301	142	19	-	-	PUNCT
dti-1301	142	20	glycoprotein	glycoprotein	NOUN
dti-1301	142	21	(	(	PUNCT
dti-1301	142	22	p	p	NOUN
dti-1301	142	23	-	-	PUNCT
dti-1301	142	24	gp	gp	NOUN
dti-1301	142	25	)	)	PUNCT
dti-1301	142	26	,	,	PUNCT
dti-1301	142	27	an	an	DET
dti-1301	142	28	mdr1	mdr1	PROPN
dti-1301	142	29	gene	gene	NOUN
dti-1301	142	30	product	product	NOUN
dti-1301	142	31	,	,	PUNCT
dti-1301	142	32	is	be	AUX
dti-1301	142	33	the	the	DET
dti-1301	142	34	most	most	ADV
dti-1301	142	35	extensively	extensively	ADV
dti-1301	142	36	studied	study	VERB
dti-1301	142	37	member	member	NOUN
dti-1301	142	38	of	of	ADP
dti-1301	142	39	the	the	DET
dti-1301	142	40	superfamily	superfamily	NOUN
dti-1301	142	41	of	of	ADP
dti-1301	142	42	atp	atp	NOUN
dti-1301	142	43	-	-	PUNCT
dti-1301	142	44	binding	bind	VERB
dti-1301	142	45	cassette	cassette	NOUN
dti-1301	142	46	(	(	PUNCT
dti-1301	142	47	abc	abc	PROPN
dti-1301	142	48	)	)	PUNCT
dti-1301	142	49	transporters	transporter	NOUN
dti-1301	142	50	.	.	PUNCT
dti-1301	143	1	p	p	X
dti-1301	143	2	-	-	PUNCT
dti-1301	143	3	gp	gp	NOUN
dti-1301	143	4	is	be	AUX
dti-1301	143	5	associated	associate	VERB
dti-1301	143	6	with	with	ADP
dti-1301	143	7	multi	multi	ADJ
dti-1301	143	8	-	-	ADJ
dti-1301	143	9	drug	drug	ADJ
dti-1301	143	10	resistance	resistance	NOUN
dti-1301	143	11	(	(	PUNCT
dti-1301	143	12	mdr	mdr	PROPN
dti-1301	143	13	)	)	PUNCT
dti-1301	143	14	in	in	ADP
dti-1301	143	15	cancer	cancer	NOUN
dti-1301	143	16	cells	cell	NOUN
dti-1301	143	17	,	,	PUNCT
dti-1301	143	18	which	which	PRON
dti-1301	143	19	is	be	AUX
dti-1301	143	20	responsible	responsible	ADJ
dti-1301	143	21	for	for	ADP
dti-1301	143	22	failure	failure	NOUN
dti-1301	143	23	of	of	ADP
dti-1301	143	24	chemotherapy	chemotherapy	NOUN
dti-1301	143	25	with	with	ADP
dti-1301	143	26	many	many	ADJ
dti-1301	143	27	drugs	drug	NOUN
dti-1301	143	28	.	.	PUNCT
dti-1301	144	1	although	although	SCONJ
dti-1301	144	2	p	p	NOUN
dti-1301	144	3	-	-	PUNCT
dti-1301	144	4	gp	gp	NOUN
dti-1301	144	5	is	be	AUX
dti-1301	144	6	over	over	ADV
dti-1301	144	7	-	-	PUNCT
dti-1301	144	8	expressed	express	VERB
dti-1301	144	9	in	in	ADP
dti-1301	144	10	tumors	tumor	NOUN
dti-1301	144	11	,	,	PUNCT
dti-1301	144	12	it	it	PRON
dti-1301	144	13	is	be	AUX
dti-1301	144	14	also	also	ADV
dti-1301	144	15	localized	localize	VERB
dti-1301	144	16	in	in	ADP
dti-1301	144	17	several	several	ADJ
dti-1301	144	18	tissues	tissue	NOUN
dti-1301	144	19	,	,	PUNCT
dti-1301	144	20	particularly	particularly	ADV
dti-1301	144	21	in	in	ADP
dti-1301	144	22	the	the	DET
dti-1301	144	23	columnar	columnar	ADJ
dti-1301	144	24	epithelial	epithelial	ADJ
dti-1301	144	25	cells	cell	NOUN
dti-1301	144	26	of	of	ADP
dti-1301	144	27	the	the	DET
dti-1301	144	28	lower	low	ADJ
dti-1301	144	29	gastrointestinal	gastrointestinal	ADJ
dti-1301	144	30	tract	tract	NOUN
dti-1301	144	31	,	,	PUNCT
dti-1301	144	32	capillary	capillary	ADJ
dti-1301	144	33	endothelial	endothelial	ADJ
dti-1301	144	34	cells	cell	NOUN
dti-1301	144	35	of	of	ADP
dti-1301	144	36	the	the	DET
dti-1301	144	37	brain	brain	NOUN
dti-1301	144	38	and	and	CCONJ
dti-1301	144	39	testis	testis	NOUN
dti-1301	144	40	,	,	PUNCT
dti-1301	144	41	canalicular	canalicular	ADJ
dti-1301	144	42	surface	surface	NOUN
dti-1301	144	43	of	of	ADP
dti-1301	144	44	the	the	DET
dti-1301	144	45	hepatocytes	hepatocyte	NOUN
dti-1301	144	46	and	and	CCONJ
dti-1301	144	47	on	on	ADP
dti-1301	144	48	the	the	DET
dti-1301	144	49	apical	apical	ADJ
dti-1301	144	50	surface	surface	NOUN
dti-1301	144	51	of	of	ADP
dti-1301	144	52	the	the	DET
dti-1301	144	53	proximal	proximal	ADJ
dti-1301	144	54	tubules	tubule	NOUN
dti-1301	144	55	in	in	ADP
dti-1301	144	56	the	the	DET
dti-1301	144	57	kidney	kidney	NOUN
dti-1301	144	58	.	.	PUNCT
dti-1301	145	1	clinically	clinically	ADV
dti-1301	145	2	,	,	PUNCT
dti-1301	145	3	this	this	DET
dti-1301	145	4	efflux	efflux	NOUN
dti-1301	145	5	transporter	transporter	NOUN
dti-1301	145	6	plays	play	VERB
dti-1301	145	7	an	an	DET
dti-1301	145	8	important	important	ADJ
dti-1301	145	9	role	role	NOUN
dti-1301	145	10	in	in	ADP
dti-1301	145	11	the	the	DET
dti-1301	145	12	absorption	absorption	NOUN
dti-1301	145	13	,	,	PUNCT
dti-1301	145	14	disposition	disposition	NOUN
dti-1301	145	15	,	,	PUNCT
dti-1301	145	16	metabolism	metabolism	NOUN
dti-1301	145	17	and	and	CCONJ
dti-1301	145	18	excretion	excretion	NOUN
dti-1301	145	19	of	of	ADP
dti-1301	145	20	a	a	DET
dti-1301	145	21	variety	variety	NOUN
dti-1301	145	22	of	of	ADP
dti-1301	145	23	drugs	drug	NOUN
dti-1301	145	24	.	.	PUNCT
dti-1301	146	1	it	it	PRON
dti-1301	146	2	constitutes	constitute	VERB
dti-1301	146	3	a	a	DET
dti-1301	146	4	formidable	formidable	ADJ
dti-1301	146	5	barrier	barrier	NOUN
dti-1301	146	6	against	against	ADP
dti-1301	146	7	drug	drug	NOUN
dti-1301	146	8	absorption	absorption	NOUN
dti-1301	146	9	by	by	ADP
dti-1301	146	10	limiting	limit	VERB
dti-1301	146	11	drug	drug	NOUN
dti-1301	146	12	uptake	uptake	NOUN
dti-1301	146	13	from	from	ADP
dti-1301	146	14	the	the	DET
dti-1301	146	15	intestinal	intestinal	ADJ
dti-1301	146	16	lumen	luman	NOUN
dti-1301	146	17	into	into	ADP
dti-1301	146	18	the	the	DET
dti-1301	146	19	systemic	systemic	ADJ
dti-1301	146	20	circulation	circulation	NOUN
dti-1301	146	21	.	.	PUNCT
dti-1301	147	1	furthermore	furthermore	ADV
dti-1301	147	2	,	,	PUNCT
dti-1301	147	3	it	it	PRON
dti-1301	147	4	pumps	pump	VERB
dti-1301	147	5	drug	drug	NOUN
dti-1301	147	6	molecules	molecule	NOUN
dti-1301	147	7	out	out	ADP
dti-1301	147	8	from	from	ADP
dti-1301	147	9	hepatocytes	hepatocyte	NOUN
dti-1301	147	10	into	into	ADP
dti-1301	147	11	the	the	DET
dti-1301	147	12	canalicular	canalicular	ADJ
dti-1301	147	13	system	system	NOUN
dti-1301	147	14	,	,	PUNCT
dti-1301	147	15	prevents	prevent	VERB
dti-1301	147	16	distribution	distribution	NOUN
dti-1301	147	17	of	of	ADP
dti-1301	147	18	drugs	drug	NOUN
dti-1301	147	19	to	to	ADP
dti-1301	147	20	the	the	DET
dti-1301	147	21	brain	brain	NOUN
dti-1301	147	22	and	and	CCONJ
dti-1301	147	23	restricts	restrict	VERB
dti-1301	147	24	re	re	NOUN
dti-1301	147	25	-	-	NOUN
dti-1301	147	26	absorption	absorption	NOUN
dti-1301	147	27	of	of	ADP
dti-1301	147	28	drug	drug	NOUN
dti-1301	147	29	into	into	ADP
dti-1301	147	30	the	the	DET
dti-1301	147	31	systemic	systemic	ADJ
dti-1301	147	32	circulation	circulation	NOUN
dti-1301	147	33	from	from	ADP
dti-1301	147	34	renal	renal	ADJ
dti-1301	147	35	tubules	tubule	NOUN
dti-1301	147	36	(	(	PUNCT
dti-1301	147	37	katragadda	katragadda	PROPN
dti-1301	147	38	et	et	PROPN
dti-1301	147	39	al	al	PROPN
dti-1301	147	40	.	.	PROPN
dti-1301	147	41	2005	2005	NUM
dti-1301	147	42	;	;	PUNCT
dti-1301	147	43	ambudkar	ambudkar	NOUN
dti-1301	147	44	et	et	PROPN
dti-1301	147	45	al	al	PROPN
dti-1301	147	46	.	.	PROPN
dti-1301	147	47	2006	2006	NUM
dti-1301	147	48	;	;	PUNCT
dti-1301	147	49	varma	varma	PROPN
dti-1301	147	50	et	et	PROPN
dti-1301	147	51	al	al	PROPN
dti-1301	147	52	.	.	PROPN
dti-1301	147	53	2006	2006	NUM
dti-1301	147	54	)	)	PUNCT
dti-1301	147	55	.	.	PUNCT
dti-1301	148	1	the	the	DET
dti-1301	148	2	hypothesis	hypothesis	NOUN
dti-1301	148	3	that	that	PRON
dti-1301	148	4	inhibition	inhibition	NOUN
dti-1301	148	5	of	of	ADP
dti-1301	148	6	p	p	NOUN
dti-1301	148	7	-	-	PUNCT
dti-1301	148	8	gp	gp	NOUN
dti-1301	148	9	improves	improve	VERB
dti-1301	148	10	the	the	DET
dti-1301	148	11	bioavailability	bioavailability	NOUN
dti-1301	148	12	of	of	ADP
dti-1301	148	13	drugs	drug	NOUN
dti-1301	148	14	that	that	PRON
dti-1301	148	15	are	be	AUX
dti-1301	148	16	substrates	substrate	NOUN
dti-1301	148	17	for	for	ADP
dti-1301	148	18	this	this	DET
dti-1301	148	19	effl	effl	NOUN
dti-1301	148	20	ux	ux	PROPN
dti-1301	148	21	transporter	transporter	NOUN
dti-1301	148	22	is	be	AUX
dti-1301	148	23	gaining	gain	VERB
dti-1301	148	24	widespread	widespread	ADJ
dti-1301	148	25	recognition	recognition	NOUN
dti-1301	148	26	.	.	PUNCT
dti-1301	149	1	moreover	moreover	ADV
dti-1301	149	2	,	,	PUNCT
dti-1301	149	3	the	the	DET
dti-1301	149	4	pharmacokinetic	pharmacokinetic	ADJ
dti-1301	149	5	advantages	advantage	NOUN
dti-1301	149	6	of	of	ADP
dti-1301	149	7	p	p	NOUN
dti-1301	149	8	-	-	PUNCT
dti-1301	149	9	gp	gp	NOUN
dti-1301	149	10	inhibition	inhibition	NOUN
dti-1301	149	11	includes	include	VERB
dti-1301	149	12	improved	improve	VERB
dti-1301	149	13	effi	effi	PROPN
dti-1301	149	14	cacy	cacy	NOUN
dti-1301	149	15	of	of	ADP
dti-1301	149	16	chemotherapeutic	chemotherapeutic	ADJ
dti-1301	149	17	agents	agent	NOUN
dti-1301	149	18	,	,	PUNCT
dti-1301	149	19	enhanced	enhance	VERB
dti-1301	149	20	intestinal	intestinal	ADJ
dti-1301	149	21	absorption	absorption	NOUN
dti-1301	149	22	and	and	CCONJ
dti-1301	149	23	reduced	reduced	ADJ
dti-1301	149	24	clearance	clearance	NOUN
dti-1301	149	25	.	.	PUNCT
dti-1301	150	1	oral	oral	ADJ
dti-1301	150	2	co	co	NOUN
dti-1301	150	3	-	-	NOUN
dti-1301	150	4	administration	administration	NOUN
dti-1301	150	5	of	of	ADP
dti-1301	150	6	the	the	DET
dti-1301	150	7	p	p	NOUN
dti-1301	150	8	-	-	PUNCT
dti-1301	150	9	gp	gp	NOUN
dti-1301	150	10	inhibitor	inhibitor	NOUN
dti-1301	150	11	,	,	PUNCT
dti-1301	150	12	verapamil	verapamil	NOUN
dti-1301	150	13	,	,	PUNCT
dti-1301	150	14	has	have	AUX
dti-1301	150	15	demonstrated	demonstrate	VERB
dti-1301	150	16	an	an	DET
dti-1301	150	17	increase	increase	NOUN
dti-1301	150	18	in	in	ADP
dti-1301	150	19	the	the	DET
dti-1301	150	20	peak	peak	NOUN
dti-1301	150	21	plasma	plasma	NOUN
dti-1301	150	22	level	level	NOUN
dti-1301	150	23	and	and	CCONJ
dti-1301	150	24	volume	volume	NOUN
dti-1301	150	25	of	of	ADP
dti-1301	150	26	distribution	distribution	NOUN
dti-1301	150	27	as	as	ADV
dti-1301	150	28	well	well	ADV
dti-1301	150	29	as	as	ADP
dti-1301	150	30	a	a	DET
dti-1301	150	31	prolonged	prolonged	ADJ
dti-1301	150	32	halflife	halflife	NOUN
dti-1301	150	33	of	of	ADP
dti-1301	150	34	doxorubicin	doxorubicin	PROPN
dti-1301	150	35	.	.	PUNCT
dti-1301	151	1	however	however	ADV
dti-1301	151	2	,	,	PUNCT
dti-1301	151	3	these	these	DET
dti-1301	151	4	fi	fi	NOUN
dti-1301	151	5	rst	rst	ADJ
dti-1301	151	6	generation	generation	NOUN
dti-1301	151	7	p	p	NOUN
dti-1301	151	8	-	-	PUNCT
dti-1301	151	9	gp	gp	NOUN
dti-1301	151	10	inhibitors	inhibitor	NOUN
dti-1301	151	11	pose	pose	VERB
dti-1301	151	12	a	a	DET
dti-1301	151	13	pharmacological	pharmacological	ADJ
dti-1301	151	14	effect	effect	NOUN
dti-1301	151	15	themselves	themselves	PRON
dti-1301	151	16	and	and	CCONJ
dti-1301	151	17	therefore	therefore	ADV
dti-1301	151	18	possible	possible	ADJ
dti-1301	151	19	toxic	toxic	ADJ
dti-1301	151	20	and	and	CCONJ
dti-1301	151	21	or	or	CCONJ
dti-1301	151	22	other	other	ADJ
dti-1301	151	23	unwanted	unwanted	ADJ
dti-1301	151	24	effects	effect	NOUN
dti-1301	151	25	may	may	AUX
dti-1301	151	26	occur	occur	VERB
dti-1301	151	27	.	.	PUNCT
dti-1301	152	1	this	this	PRON
dti-1301	152	2	has	have	AUX
dti-1301	152	3	led	lead	VERB
dti-1301	152	4	to	to	ADP
dti-1301	152	5	the	the	DET
dti-1301	152	6	design	design	NOUN
dti-1301	152	7	of	of	ADP
dti-1301	152	8	second	second	ADJ
dti-1301	152	9	and	and	CCONJ
dti-1301	152	10	third	third	ADJ
dti-1301	152	11	generation	generation	NOUN
dti-1301	152	12	p	p	NOUN
dti-1301	152	13	-	-	PUNCT
dti-1301	152	14	gp	gp	NOUN
dti-1301	152	15	inhibitors	inhibitor	NOUN
dti-1301	152	16	with	with	ADP
dti-1301	152	17	the	the	DET
dti-1301	152	18	potential	potential	NOUN
dti-1301	152	19	to	to	PART
dti-1301	152	20	enhance	enhance	VERB
dti-1301	152	21	the	the	DET
dti-1301	152	22	absorption	absorption	NOUN
dti-1301	152	23	of	of	ADP
dti-1301	152	24	p	p	NOUN
dti-1301	152	25	-	-	PUNCT
dti-1301	152	26	gp	gp	NOUN
dti-1301	152	27	substrates	substrate	NOUN
dti-1301	152	28	without	without	ADP
dti-1301	152	29	undesirable	undesirable	ADJ
dti-1301	152	30	pharmacologic	pharmacologic	ADJ
dti-1301	152	31	or	or	CCONJ
dti-1301	152	32	toxic	toxic	ADJ
dti-1301	152	33	effects	effect	NOUN
dti-1301	152	34	(	(	PUNCT
dti-1301	152	35	varma	varma	PROPN
dti-1301	152	36	et	et	PROPN
dti-1301	152	37	al	al	PROPN
dti-1301	152	38	.	.	PROPN
dti-1301	152	39	2003	2003	NUM
dti-1301	152	40	)	)	PUNCT
dti-1301	152	41	.	.	PUNCT
dti-1301	153	1	examples	example	NOUN
dti-1301	153	2	of	of	ADP
dti-1301	153	3	pro	pro	ADJ
dti-1301	153	4	-	-	NOUN
dti-1301	153	5	drugs	drug	NOUN
dti-1301	153	6	that	that	PRON
dti-1301	153	7	target	target	VERB
dti-1301	153	8	an	an	DET
dti-1301	153	9	active	active	ADJ
dti-1301	153	10	transporter	transporter	NOUN
dti-1301	153	11	and	and	CCONJ
dti-1301	153	12	simultaneously	simultaneously	ADV
dti-1301	153	13	decrease	decrease	VERB
dti-1301	153	14	the	the	DET
dti-1301	153	15	substrate	substrate	NOUN
dti-1301	153	16	’s	’s	PART
dti-1301	153	17	interaction	interaction	NOUN
dti-1301	153	18	with	with	ADP
dti-1301	153	19	p	p	NOUN
dti-1301	153	20	-	-	PUNCT
dti-1301	153	21	gp	gp	NOUN
dti-1301	153	22	are	be	AUX
dti-1301	153	23	the	the	DET
dti-1301	153	24	dipeptides	dipeptide	NOUN
dti-1301	153	25	derivatives	derivative	NOUN
dti-1301	153	26	of	of	ADP
dti-1301	153	27	saquinavir	saquinavir	NOUN
dti-1301	153	28	,	,	PUNCT
dti-1301	153	29	namely	namely	ADV
dti-1301	153	30	l	l	NOUN
dti-1301	153	31	-	-	NOUN
dti-1301	153	32	valine	valine	NOUN
dti-1301	153	33	-	-	PUNCT
dti-1301	153	34	l	l	NOUN
dti-1301	153	35	-	-	PUNCT
dti-1301	153	36	valinesaquinavir	valinesaquinavir	PROPN
dti-1301	153	37	and	and	CCONJ
dti-1301	153	38	l	l	NOUN
dti-1301	153	39	-	-	NOUN
dti-1301	153	40	glycine	glycine	ADJ
dti-1301	153	41	-	-	PUNCT
dti-1301	153	42	l	l	NOUN
dti-1301	153	43	-	-	PUNCT
dti-1301	153	44	valine	valine	NOUN
dti-1301	153	45	-	-	PUNCT
dti-1301	153	46	saquinavir	saquinavir	NOUN
dti-1301	153	47	.	.	PUNCT
dti-1301	154	1	these	these	DET
dti-1301	154	2	dipeptides	dipeptide	NOUN
dti-1301	154	3	pro	pro	ADJ
dti-1301	154	4	-	-	NOUN
dti-1301	154	5	drugs	drug	NOUN
dti-1301	154	6	that	that	PRON
dti-1301	154	7	target	target	VERB
dti-1301	154	8	peptide	peptide	NOUN
dti-1301	154	9	transporters	transporter	NOUN
dti-1301	154	10	and	and	CCONJ
dti-1301	154	11	diminish	diminish	VERB
dti-1301	154	12	interaction	interaction	NOUN
dti-1301	154	13	with	with	ADP
dti-1301	154	14	p	p	NOUN
dti-1301	154	15	-	-	PUNCT
dti-1301	154	16	gp	gp	NOUN
dti-1301	154	17	exhibited	exhibit	VERB
dti-1301	154	18	an	an	DET
dti-1301	154	19	overall	overall	ADJ
dti-1301	154	20	increased	increase	VERB
dti-1301	154	21	transport	transport	NOUN
dti-1301	154	22	from	from	ADP
dti-1301	154	23	the	the	DET
dti-1301	154	24	apical	apical	ADJ
dti-1301	154	25	to	to	ADP
dti-1301	154	26	basolateral	basolateral	ADJ
dti-1301	154	27	side	side	NOUN
dti-1301	154	28	in	in	ADP
dti-1301	154	29	caco-2	caco-2	NUM
dti-1301	154	30	cell	cell	NOUN
dti-1301	154	31	monolayers	monolayer	NOUN
dti-1301	154	32	.	.	PUNCT
dti-1301	155	1	this	this	DET
dti-1301	155	2	example	example	NOUN
dti-1301	155	3	shows	show	VERB
dti-1301	155	4	the	the	DET
dti-1301	155	5	potential	potential	NOUN
dti-1301	155	6	of	of	ADP
dti-1301	155	7	rational	rational	ADJ
dti-1301	155	8	pro	pro	ADJ
dti-1301	155	9	-	-	ADJ
dti-1301	155	10	drug	drug	ADJ
dti-1301	155	11	design	design	NOUN
dti-1301	155	12	to	to	PART
dti-1301	155	13	decrease	decrease	VERB
dti-1301	155	14	p	p	X
dti-1301	155	15	-	-	PUNCT
dti-1301	155	16	gp	gp	NOUN
dti-1301	155	17	mediated	mediate	VERB
dti-1301	155	18	efflux	efflux	NOUN
dti-1301	155	19	and	and	CCONJ
dti-1301	155	20	thereby	thereby	ADV
dti-1301	155	21	increase	increase	VERB
dti-1301	155	22	the	the	DET
dti-1301	155	23	absorption	absorption	NOUN
dti-1301	155	24	of	of	ADP
dti-1301	155	25	drugs	drug	NOUN
dti-1301	155	26	that	that	PRON
dti-1301	155	27	are	be	AUX
dti-1301	155	28	substrates	substrate	NOUN
dti-1301	155	29	for	for	ADP
dti-1301	155	30	this	this	DET
dti-1301	155	31	effl	effl	PROPN
dti-1301	155	32	ux	ux	PROPN
dti-1301	155	33	pump	pump	PROPN
dti-1301	155	34	(	(	PUNCT
dti-1301	155	35	majumdar	majumdar	PROPN
dti-1301	155	36	and	and	CCONJ
dti-1301	155	37	mitra	mitra	PROPN
dti-1301	155	38	,	,	PUNCT
dti-1301	155	39	2006	2006	NUM
dti-1301	155	40	)	)	PUNCT
dti-1301	155	41	.	.	PUNCT
dti-1301	156	1	site	site	NOUN
dti-1301	156	2	of	of	ADP
dti-1301	156	3	absorption	absorption	NOUN
dti-1301	156	4	site	site	NOUN
dti-1301	156	5	-	-	PUNCT
dti-1301	156	6	specific	specific	ADJ
dti-1301	156	7	absorption	absorption	NOUN
dti-1301	156	8	occurs	occur	VERB
dti-1301	156	9	in	in	ADP
dti-1301	156	10	the	the	DET
dti-1301	156	11	gastrointestinal	gastrointestinal	ADJ
dti-1301	156	12	tract	tract	NOUN
dti-1301	156	13	because	because	SCONJ
dti-1301	156	14	of	of	ADP
dti-1301	156	15	differences	difference	NOUN
dti-1301	156	16	in	in	ADP
dti-1301	156	17	the	the	DET
dti-1301	156	18	composition	composition	NOUN
dti-1301	156	19	and	and	CCONJ
dti-1301	156	20	thickness	thickness	NOUN
dti-1301	156	21	of	of	ADP
dti-1301	156	22	the	the	DET
dti-1301	156	23	mucus	mucus	NOUN
dti-1301	156	24	layer	layer	NOUN
dti-1301	156	25	,	,	PUNCT
dti-1301	156	26	ph	ph	ADJ
dti-1301	156	27	,	,	PUNCT
dti-1301	156	28	surface	surface	NOUN
dti-1301	156	29	area	area	NOUN
dti-1301	156	30	and	and	CCONJ
dti-1301	156	31	enzyme	enzyme	NOUN
dti-1301	156	32	activity	activity	NOUN
dti-1301	156	33	(	(	PUNCT
dti-1301	156	34	hamman	hamman	PROPN
dti-1301	156	35	et	et	PROPN
dti-1301	156	36	al	al	PROPN
dti-1301	156	37	.	.	PROPN
dti-1301	156	38	2005	2005	NUM
dti-1301	156	39	)	)	PUNCT
dti-1301	156	40	.	.	PUNCT
dti-1301	157	1	furthermore	furthermore	ADV
dti-1301	157	2	,	,	PUNCT
dti-1301	157	3	the	the	DET
dti-1301	157	4	physicochemical	physicochemical	ADJ
dti-1301	157	5	properties	property	NOUN
dti-1301	157	6	of	of	ADP
dti-1301	157	7	the	the	DET
dti-1301	157	8	drug	drug	NOUN
dti-1301	157	9	not	not	PART
dti-1301	157	10	only	only	ADV
dti-1301	157	11	influence	influence	VERB
dti-1301	157	12	the	the	DET
dti-1301	157	13	site	site	NOUN
dti-1301	157	14	of	of	ADP
dti-1301	157	15	absorption	absorption	NOUN
dti-1301	157	16	but	but	CCONJ
dti-1301	157	17	also	also	ADV
dti-1301	157	18	the	the	DET
dti-1301	157	19	mechanism	mechanism	NOUN
dti-1301	157	20	of	of	ADP
dti-1301	157	21	absorption	absorption	NOUN
dti-1301	157	22	.	.	PUNCT
dti-1301	158	1	despite	despite	SCONJ
dti-1301	158	2	these	these	DET
dti-1301	158	3	differences	difference	NOUN
dti-1301	158	4	the	the	DET
dti-1301	158	5	most	most	ADV
dti-1301	158	6	important	important	ADJ
dti-1301	158	7	site	site	NOUN
dti-1301	158	8	for	for	ADP
dti-1301	158	9	intestinal	intestinal	ADJ
dti-1301	158	10	drug	drug	NOUN
dti-1301	158	11	absorption	absorption	NOUN
dti-1301	158	12	is	be	AUX
dti-1301	158	13	the	the	DET
dti-1301	158	14	small	small	ADJ
dti-1301	158	15	intestine	intestine	NOUN
dti-1301	158	16	(	(	PUNCT
dti-1301	158	17	lacombe	lacombe	NOUN
dti-1301	158	18	et	et	PROPN
dti-1301	158	19	al	al	PROPN
dti-1301	158	20	.	.	PROPN
dti-1301	158	21	2004	2004	NUM
dti-1301	158	22	,	,	PUNCT
dti-1301	158	23	masaoka	masaoka	VERB
dti-1301	158	24	et	et	PROPN
dti-1301	158	25	al	al	PROPN
dti-1301	158	26	.	.	PROPN
dti-1301	158	27	2006	2006	NUM
dti-1301	158	28	)	)	PUNCT
dti-1301	158	29	.	.	PUNCT
dti-1301	159	1	in	in	ADP
dti-1301	159	2	general	general	ADJ
dti-1301	159	3	,	,	PUNCT
dti-1301	159	4	drug	drug	NOUN
dti-1301	159	5	permeability	permeability	NOUN
dti-1301	159	6	is	be	AUX
dti-1301	159	7	accepted	accept	VERB
dti-1301	159	8	to	to	PART
dti-1301	159	9	be	be	AUX
dti-1301	159	10	higher	high	ADJ
dti-1301	159	11	in	in	ADP
dti-1301	159	12	the	the	DET
dti-1301	159	13	upper	upper	ADJ
dti-1301	159	14	region	region	NOUN
dti-1301	159	15	of	of	ADP
dti-1301	159	16	the	the	DET
dti-1301	159	17	gastrointestinal	gastrointestinal	ADJ
dti-1301	159	18	tract	tract	NOUN
dti-1301	159	19	compared	compare	VERB
dti-1301	159	20	to	to	ADP
dti-1301	159	21	the	the	DET
dti-1301	159	22	lower	low	ADJ
dti-1301	159	23	parts	part	NOUN
dti-1301	159	24	(	(	PUNCT
dti-1301	159	25	masaoka	masaoka	NOUN
dti-1301	159	26	et	et	PROPN
dti-1301	159	27	al	al	PROPN
dti-1301	159	28	.	.	PROPN
dti-1301	159	29	2006	2006	NUM
dti-1301	159	30	)	)	PUNCT
dti-1301	159	31	.	.	PUNCT
dti-1301	160	1	timing	timing	NOUN
dti-1301	160	2	of	of	ADP
dti-1301	160	3	drug	drug	NOUN
dti-1301	160	4	delivery	delivery	NOUN
dti-1301	160	5	is	be	AUX
dti-1301	160	6	therefore	therefore	ADV
dti-1301	160	7	important	important	ADJ
dti-1301	160	8	for	for	ADP
dti-1301	160	9	optimized	optimize	VERB
dti-1301	160	10	absorption	absorption	NOUN
dti-1301	160	11	and	and	CCONJ
dti-1301	160	12	in	in	ADP
dti-1301	160	13	diseases	disease	NOUN
dti-1301	160	14	that	that	PRON
dti-1301	160	15	are	be	AUX
dti-1301	160	16	related	relate	VERB
dti-1301	160	17	to	to	ADP
dti-1301	160	18	the	the	DET
dti-1301	160	19	circadian	circadian	ADJ
dti-1301	160	20	rhythm	rhythm	NOUN
dti-1301	160	21	such	such	ADJ
dti-1301	160	22	as	as	ADP
dti-1301	160	23	asthma	asthma	NOUN
dti-1301	160	24	and	and	CCONJ
dti-1301	160	25	rheumatoid	rheumatoid	VERB
dti-1301	160	26	arthritis	arthritis	NOUN
dti-1301	160	27	(	(	PUNCT
dti-1301	160	28	weidner	weidner	NOUN
dti-1301	160	29	,	,	PUNCT
dti-1301	160	30	2001	2001	NUM
dti-1301	160	31	)	)	PUNCT
dti-1301	160	32	.	.	PUNCT
dti-1301	161	1	in	in	ADP
dti-1301	161	2	a	a	DET
dti-1301	161	3	recent	recent	ADJ
dti-1301	161	4	study	study	NOUN
dti-1301	161	5	by	by	ADP
dti-1301	161	6	masaoke	masaoke	PROPN
dti-1301	161	7	et	et	PROPN
dti-1301	161	8	al	al	PROPN
dti-1301	161	9	.	.	PROPN
dti-1301	161	10	(	(	PUNCT
dti-1301	161	11	2006	2006	NUM
dti-1301	161	12	)	)	PUNCT
dti-1301	161	13	,	,	PUNCT
dti-1301	161	14	various	various	ADJ
dti-1301	161	15	factors	factor	NOUN
dti-1301	161	16	that	that	PRON
dti-1301	161	17	may	may	AUX
dti-1301	161	18	contribute	contribute	VERB
dti-1301	161	19	to	to	ADP
dti-1301	161	20	the	the	DET
dti-1301	161	21	regional	regional	ADJ
dti-1301	161	22	absorption	absorption	NOUN
dti-1301	161	23	of	of	ADP
dti-1301	161	24	drugs	drug	NOUN
dti-1301	161	25	from	from	ADP
dti-1301	161	26	the	the	DET
dti-1301	161	27	intestine	intestine	NOUN
dti-1301	161	28	were	be	AUX
dti-1301	161	29	studied	study	VERB
dti-1301	161	30	.	.	PUNCT
dti-1301	162	1	they	they	PRON
dti-1301	162	2	concluded	conclude	VERB
dti-1301	162	3	that	that	SCONJ
dti-1301	162	4	the	the	DET
dti-1301	162	5	epithelial	epithelial	ADJ
dti-1301	162	6	surface	surface	NOUN
dti-1301	162	7	area	area	NOUN
dti-1301	162	8	should	should	AUX
dti-1301	162	9	not	not	PART
dti-1301	162	10	be	be	AUX
dti-1301	162	11	a	a	DET
dti-1301	162	12	determining	determine	VERB
dti-1301	162	13	factor	factor	NOUN
dti-1301	162	14	in	in	ADP
dti-1301	162	15	drug	drug	NOUN
dti-1301	162	16	absorption	absorption	NOUN
dti-1301	162	17	for	for	ADP
dti-1301	162	18	highly	highly	ADV
dti-1301	162	19	permeable	permeable	ADJ
dti-1301	162	20	drugs	drug	NOUN
dti-1301	162	21	in	in	ADP
dti-1301	162	22	the	the	DET
dti-1301	162	23	different	different	ADJ
dti-1301	162	24	regions	region	NOUN
dti-1301	162	25	of	of	ADP
dti-1301	162	26	the	the	DET
dti-1301	162	27	gastrointestinal	gastrointestinal	ADJ
dti-1301	162	28	tract	tract	NOUN
dti-1301	162	29	.	.	PUNCT
dti-1301	163	1	in	in	ADP
dti-1301	163	2	contrast	contrast	NOUN
dti-1301	163	3	,	,	PUNCT
dti-1301	163	4	the	the	DET
dti-1301	163	5	effects	effect	NOUN
dti-1301	163	6	of	of	ADP
dti-1301	163	7	the	the	DET
dti-1301	163	8	mucus	mucus	NOUN
dti-1301	163	9	layer	layer	NOUN
dti-1301	163	10	and	and	CCONJ
dti-1301	163	11	fl	fl	ADP
dti-1301	163	12	uidity	uidity	NOUN
dti-1301	163	13	of	of	ADP
dti-1301	163	14	the	the	DET
dti-1301	163	15	cell	cell	NOUN
dti-1301	163	16	membrane	membrane	NOUN
dti-1301	163	17	of	of	ADP
dti-1301	163	18	the	the	DET
dti-1301	163	19	different	different	ADJ
dti-1301	163	20	regions	region	NOUN
dti-1301	163	21	were	be	AUX
dti-1301	163	22	found	find	VERB
dti-1301	163	23	to	to	PART
dti-1301	163	24	contribute	contribute	VERB
dti-1301	163	25	to	to	ADP
dti-1301	163	26	dissimilarities	dissimilarity	NOUN
dti-1301	163	27	in	in	ADP
dti-1301	163	28	intestinal	intestinal	ADJ
dti-1301	163	29	drug	drug	NOUN
dti-1301	163	30	permeability	permeability	NOUN
dti-1301	163	31	.	.	PUNCT
dti-1301	164	1	regional	regional	ADJ
dti-1301	164	2	membrane	membrane	NOUN
dti-1301	164	3	fluidity	fluidity	NOUN
dti-1301	164	4	decreased	decrease	VERB
dti-1301	164	5	from	from	ADP
dti-1301	164	6	the	the	DET
dti-1301	164	7	upper	upper	NOUN
dti-1301	164	8	to	to	ADP
dti-1301	164	9	the	the	DET
dti-1301	164	10	lower	low	ADJ
dti-1301	164	11	parts	part	NOUN
dti-1301	164	12	of	of	ADP
dti-1301	164	13	the	the	DET
dti-1301	164	14	gastrointestinal	gastrointestinal	ADJ
dti-1301	164	15	tract	tract	NOUN
dti-1301	164	16	.	.	PUNCT
dti-1301	165	1	atenolol	atenolol	PROPN
dti-1301	165	2	,	,	PUNCT
dti-1301	165	3	a	a	DET
dti-1301	165	4	drug	drug	NOUN
dti-1301	165	5	with	with	ADP
dti-1301	165	6	low	low	ADJ
dti-1301	165	7	permeability	permeability	NOUN
dti-1301	165	8	,	,	PUNCT
dti-1301	165	9	was	be	AUX
dti-1301	165	10	observed	observe	VERB
dti-1301	165	11	to	to	PART
dti-1301	165	12	be	be	AUX
dti-1301	165	13	absorbed	absorb	VERB
dti-1301	165	14	in	in	ADP
dti-1301	165	15	the	the	DET
dti-1301	165	16	middle	middle	ADJ
dti-1301	165	17	and	and	CCONJ
dti-1301	165	18	lower	low	ADJ
dti-1301	165	19	portions	portion	NOUN
dti-1301	165	20	of	of	ADP
dti-1301	165	21	the	the	DET
dti-1301	165	22	jejunum	jejunum	NOUN
dti-1301	165	23	,	,	PUNCT
dti-1301	165	24	while	while	SCONJ
dti-1301	165	25	highly	highly	ADV
dti-1301	165	26	permeable	permeable	ADJ
dti-1301	165	27	drugs	drug	NOUN
dti-1301	165	28	such	such	ADJ
dti-1301	165	29	as	as	ADP
dti-1301	165	30	antipyrine	antipyrine	NOUN
dti-1301	165	31	and	and	CCONJ
dti-1301	165	32	metoprolol	metoprolol	NOUN
dti-1301	165	33	were	be	AUX
dti-1301	165	34	generally	generally	ADV
dti-1301	165	35	absorbed	absorb	VERB
dti-1301	165	36	in	in	ADP
dti-1301	165	37	the	the	DET
dti-1301	165	38	upper	upper	ADJ
dti-1301	165	39	part	part	NOUN
dti-1301	165	40	of	of	ADP
dti-1301	165	41	the	the	DET
dti-1301	165	42	intestine	intestine	NOUN
dti-1301	165	43	and	and	CCONJ
dti-1301	165	44	also	also	ADV
dti-1301	165	45	possibly	possibly	ADV
dti-1301	165	46	in	in	ADP
dti-1301	165	47	the	the	DET
dti-1301	165	48	stomach	stomach	NOUN
dti-1301	165	49	.	.	PUNCT
dti-1301	166	1	the	the	DET
dti-1301	166	2	drug	drug	NOUN
dti-1301	166	3	permeability	permeability	NOUN
dti-1301	166	4	of	of	ADP
dti-1301	166	5	griseofulvin	griseofulvin	NOUN
dti-1301	166	6	and	and	CCONJ
dti-1301	166	7	naproxen	naproxen	NOUN
dti-1301	166	8	was	be	AUX
dti-1301	166	9	higher	high	ADJ
dti-1301	166	10	in	in	ADP
dti-1301	166	11	the	the	DET
dti-1301	166	12	colon	colon	NOUN
dti-1301	166	13	compared	compare	VERB
dti-1301	166	14	to	to	ADP
dti-1301	166	15	the	the	DET
dti-1301	166	16	jejunum	jejunum	NOUN
dti-1301	166	17	.	.	PUNCT
dti-1301	167	1	it	it	PRON
dti-1301	167	2	was	be	AUX
dti-1301	167	3	found	find	VERB
dti-1301	167	4	that	that	SCONJ
dti-1301	167	5	removal	removal	NOUN
dti-1301	167	6	of	of	ADP
dti-1301	167	7	the	the	DET
dti-1301	167	8	mucus	mucus	NOUN
dti-1301	167	9	layer	layer	NOUN
dti-1301	167	10	of	of	ADP
dti-1301	167	11	the	the	DET
dti-1301	167	12	jejunum	jejunum	PROPN
dti-1301	167	13	signifi	signifi	NOUN
dti-1301	167	14	cantly	cantly	ADV
dti-1301	167	15	enhances	enhance	VERB
dti-1301	167	16	griseofulvin	griseofulvin	NOUN
dti-1301	167	17	absorption	absorption	NOUN
dti-1301	167	18	to	to	ADP
dti-1301	167	19	almost	almost	ADV
dti-1301	167	20	the	the	DET
dti-1301	167	21	same	same	ADJ
dti-1301	167	22	levels	level	NOUN
dti-1301	167	23	as	as	ADP
dti-1301	167	24	those	those	PRON
dti-1301	167	25	observed	observe	VERB
dti-1301	167	26	in	in	ADP
dti-1301	167	27	the	the	DET
dti-1301	167	28	ileum	ileum	NOUN
dti-1301	167	29	and	and	CCONJ
dti-1301	167	30	colon	colon	NOUN
dti-1301	167	31	.	.	PUNCT
dti-1301	168	1	they	they	PRON
dti-1301	168	2	concluded	conclude	VERB
dti-1301	168	3	that	that	SCONJ
dti-1301	168	4	the	the	DET
dti-1301	168	5	main	main	ADJ
dti-1301	168	6	factors	factor	NOUN
dti-1301	168	7	affecting	affect	VERB
dti-1301	168	8	drug	drug	NOUN
dti-1301	168	9	drug	drug	NOUN
dti-1301	168	10	target	target	NOUN
dti-1301	168	11	insights	insight	NOUN
dti-1301	168	12	2007	2007	NUM
dti-1301	168	13	:	:	PUNCT
dti-1301	168	14	278	278	NUM
dti-1301	168	15	hamman	hamman	PROPN
dti-1301	168	16	et	et	PROPN
dti-1301	168	17	al	al	PROPN
dti-1301	168	18	absorption	absorption	NOUN
dti-1301	168	19	are	be	AUX
dti-1301	168	20	membrane	membrane	ADJ
dti-1301	168	21	permeability	permeability	NOUN
dti-1301	168	22	,	,	PUNCT
dti-1301	168	23	luminal	luminal	ADJ
dti-1301	168	24	drug	drug	NOUN
dti-1301	168	25	concentration	concentration	NOUN
dti-1301	168	26	and	and	CCONJ
dti-1301	168	27	residence	residence	NOUN
dti-1301	168	28	time	time	NOUN
dti-1301	168	29	in	in	ADP
dti-1301	168	30	the	the	DET
dti-1301	168	31	different	different	ADJ
dti-1301	168	32	parts	part	NOUN
dti-1301	168	33	of	of	ADP
dti-1301	168	34	the	the	DET
dti-1301	168	35	gastrointestinal	gastrointestinal	ADJ
dti-1301	168	36	tract	tract	NOUN
dti-1301	168	37	,	,	PUNCT
dti-1301	168	38	while	while	SCONJ
dti-1301	168	39	regional	regional	ADJ
dti-1301	168	40	ph	ph	ADJ
dti-1301	168	41	differences	difference	NOUN
dti-1301	168	42	are	be	AUX
dti-1301	168	43	specifi	specifi	X
dti-1301	168	44	cally	cally	ADV
dti-1301	168	45	important	important	ADJ
dti-1301	168	46	for	for	ADP
dti-1301	168	47	poorly	poorly	ADV
dti-1301	168	48	permeable	permeable	ADJ
dti-1301	168	49	drugs	drug	NOUN
dti-1301	168	50	.	.	PUNCT
dti-1301	169	1	upper	upper	ADJ
dti-1301	169	2	gastrointestinal	gastrointestinal	ADJ
dti-1301	169	3	delivery	delivery	NOUN
dti-1301	169	4	the	the	DET
dti-1301	169	5	stomach	stomach	NOUN
dti-1301	169	6	is	be	AUX
dti-1301	169	7	responsible	responsible	ADJ
dti-1301	169	8	for	for	ADP
dti-1301	169	9	initial	initial	ADJ
dti-1301	169	10	digestion	digestion	NOUN
dti-1301	169	11	,	,	PUNCT
dti-1301	169	12	temporary	temporary	ADJ
dti-1301	169	13	food	food	NOUN
dti-1301	169	14	storage	storage	NOUN
dti-1301	169	15	and	and	CCONJ
dti-1301	169	16	controlled	control	VERB
dti-1301	169	17	release	release	NOUN
dti-1301	169	18	of	of	ADP
dti-1301	169	19	the	the	DET
dti-1301	169	20	resulting	result	VERB
dti-1301	169	21	chime	chime	NOUN
dti-1301	169	22	into	into	ADP
dti-1301	169	23	the	the	DET
dti-1301	169	24	duodenum	duodenum	NOUN
dti-1301	169	25	.	.	PUNCT
dti-1301	170	1	the	the	DET
dti-1301	170	2	small	small	ADJ
dti-1301	170	3	surface	surface	NOUN
dti-1301	170	4	area	area	NOUN
dti-1301	170	5	and	and	CCONJ
dti-1301	170	6	short	short	ADJ
dti-1301	170	7	residence	residence	NOUN
dti-1301	170	8	time	time	NOUN
dti-1301	170	9	in	in	ADP
dti-1301	170	10	the	the	DET
dti-1301	170	11	stomach	stomach	NOUN
dti-1301	170	12	limits	limit	VERB
dti-1301	170	13	gastric	gastric	ADJ
dti-1301	170	14	absorption	absorption	NOUN
dti-1301	170	15	,	,	PUNCT
dti-1301	170	16	however	however	ADV
dti-1301	170	17	,	,	PUNCT
dti-1301	170	18	gastric	gastric	ADJ
dti-1301	170	19	retentive	retentive	ADJ
dti-1301	170	20	systems	system	NOUN
dti-1301	170	21	can	can	AUX
dti-1301	170	22	be	be	AUX
dti-1301	170	23	used	use	VERB
dti-1301	170	24	for	for	ADP
dti-1301	170	25	local	local	ADJ
dti-1301	170	26	action	action	NOUN
dti-1301	170	27	in	in	ADP
dti-1301	170	28	the	the	DET
dti-1301	170	29	stomach	stomach	NOUN
dti-1301	170	30	(	(	PUNCT
dti-1301	170	31	e.g.	e.g.	ADV
dti-1301	170	32	antacids	antacid	NOUN
dti-1301	170	33	,	,	PUNCT
dti-1301	170	34	misoprostol	misoprostol	NOUN
dti-1301	170	35	,	,	PUNCT
dti-1301	170	36	antibiotics	antibiotic	NOUN
dti-1301	170	37	for	for	ADP
dti-1301	170	38	helicobacter	helicobacter	NOUN
dti-1301	170	39	pylori	pylori	NOUN
dti-1301	170	40	)	)	PUNCT
dti-1301	170	41	,	,	PUNCT
dti-1301	170	42	absorption	absorption	NOUN
dti-1301	170	43	of	of	ADP
dti-1301	170	44	drugs	drug	NOUN
dti-1301	170	45	in	in	ADP
dti-1301	170	46	the	the	DET
dti-1301	170	47	stomach	stomach	NOUN
dti-1301	170	48	and	and	CCONJ
dti-1301	170	49	upper	upper	ADJ
dti-1301	170	50	small	small	ADJ
dti-1301	170	51	intestine	intestine	NOUN
dti-1301	170	52	(	(	PUNCT
dti-1301	170	53	e.g.	e.g.	ADV
dti-1301	170	54	l	l	NOUN
dti-1301	170	55	-	-	NOUN
dti-1301	170	56	dopa	dopa	NOUN
dti-1301	170	57	,	,	PUNCT
dti-1301	170	58	p	p	NOUN
dti-1301	170	59	-	-	PUNCT
dti-1301	170	60	aminobenzoic	aminobenzoic	NOUN
dti-1301	170	61	acid	acid	NOUN
dti-1301	170	62	,	,	PUNCT
dti-1301	170	63	furosemide	furosemide	NOUN
dti-1301	170	64	,	,	PUNCT
dti-1301	170	65	ribofl	ribofl	NOUN
dti-1301	170	66	avin	avin	NOUN
dti-1301	170	67	and	and	CCONJ
dti-1301	170	68	fl	fl	NOUN
dti-1301	170	69	avin	avin	PROPN
dti-1301	170	70	mononucleotide	mononucleotide	PROPN
dti-1301	170	71	)	)	PUNCT
dti-1301	170	72	,	,	PUNCT
dti-1301	170	73	drugs	drug	NOUN
dti-1301	170	74	that	that	PRON
dti-1301	170	75	are	be	AUX
dti-1301	170	76	unstable	unstable	ADJ
dti-1301	170	77	in	in	ADP
dti-1301	170	78	the	the	DET
dti-1301	170	79	intestine	intestine	NOUN
dti-1301	170	80	and	and	CCONJ
dti-1301	170	81	colon	colon	NOUN
dti-1301	170	82	(	(	PUNCT
dti-1301	170	83	e.g.	e.g.	ADV
dti-1301	170	84	captopril	captopril	NOUN
dti-1301	170	85	and	and	CCONJ
dti-1301	170	86	ranitidine	ranitidine	NOUN
dti-1301	170	87	)	)	PUNCT
dti-1301	170	88	or	or	CCONJ
dti-1301	170	89	for	for	ADP
dti-1301	170	90	drugs	drug	NOUN
dti-1301	170	91	that	that	PRON
dti-1301	170	92	exhibit	exhibit	VERB
dti-1301	170	93	low	low	ADJ
dti-1301	170	94	solubility	solubility	NOUN
dti-1301	170	95	at	at	ADP
dti-1301	170	96	high	high	ADJ
dti-1301	170	97	ph	ph	ADJ
dti-1301	170	98	values	value	NOUN
dti-1301	170	99	(	(	PUNCT
dti-1301	170	100	e.g.	e.g.	ADV
dti-1301	170	101	diazepam	diazepam	NOUN
dti-1301	170	102	,	,	PUNCT
dti-1301	170	103	chlordiazepoxide	chlordiazepoxide	NOUN
dti-1301	170	104	and	and	CCONJ
dti-1301	170	105	verapamil	verapamil	NOUN
dti-1301	170	106	)	)	PUNCT
dti-1301	170	107	.	.	PUNCT
dti-1301	171	1	gastric	gastric	ADJ
dti-1301	171	2	retention	retention	NOUN
dti-1301	171	3	is	be	AUX
dti-1301	171	4	not	not	PART
dti-1301	171	5	desirable	desirable	ADJ
dti-1301	171	6	when	when	SCONJ
dti-1301	171	7	drugs	drug	NOUN
dti-1301	171	8	cause	cause	VERB
dti-1301	171	9	gastric	gastric	ADJ
dti-1301	171	10	irritation	irritation	NOUN
dti-1301	171	11	(	(	PUNCT
dti-1301	171	12	e.g.	e.g.	ADV
dti-1301	171	13	non	non	ADJ
dti-1301	171	14	-	-	ADJ
dti-1301	171	15	steroidal	steroidal	ADJ
dti-1301	171	16	anti	anti	ADJ
dti-1301	171	17	-	-	ADJ
dti-1301	171	18	infl	infl	ADJ
dti-1301	171	19	ammatory	ammatory	NOUN
dti-1301	171	20	drugs	drug	NOUN
dti-1301	171	21	)	)	PUNCT
dti-1301	171	22	,	,	PUNCT
dti-1301	171	23	are	be	AUX
dti-1301	171	24	unstable	unstable	ADJ
dti-1301	171	25	in	in	ADP
dti-1301	171	26	the	the	DET
dti-1301	171	27	acid	acid	ADJ
dti-1301	171	28	ph	ph	NOUN
dti-1301	171	29	of	of	ADP
dti-1301	171	30	the	the	DET
dti-1301	171	31	stomach	stomach	NOUN
dti-1301	171	32	or	or	CCONJ
dti-1301	171	33	for	for	ADP
dti-1301	171	34	drugs	drug	NOUN
dti-1301	171	35	that	that	PRON
dti-1301	171	36	exhibit	exhibit	VERB
dti-1301	171	37	significant	significant	ADJ
dti-1301	171	38	fi	fi	NOUN
dti-1301	171	39	rst	rst	VERB
dti-1301	171	40	-	-	PUNCT
dti-1301	171	41	pass	pass	VERB
dti-1301	171	42	liver	liver	NOUN
dti-1301	171	43	metabolism	metabolism	NOUN
dti-1301	171	44	(	(	PUNCT
dti-1301	171	45	e.g.	e.g.	ADV
dti-1301	171	46	nifedipine	nifedipine	NOUN
dti-1301	171	47	)	)	PUNCT
dti-1301	171	48	(	(	PUNCT
dti-1301	171	49	streubel	streubel	VERB
dti-1301	171	50	et	et	PROPN
dti-1301	171	51	al	al	PROPN
dti-1301	171	52	.	.	PROPN
dti-1301	171	53	2006	2006	NUM
dti-1301	171	54	)	)	PUNCT
dti-1301	171	55	.	.	PUNCT
dti-1301	172	1	various	various	ADJ
dti-1301	172	2	formulation	formulation	NOUN
dti-1301	172	3	techniques	technique	NOUN
dti-1301	172	4	have	have	AUX
dti-1301	172	5	been	be	AUX
dti-1301	172	6	used	use	VERB
dti-1301	172	7	to	to	PART
dti-1301	172	8	achieve	achieve	VERB
dti-1301	172	9	gastric	gastric	ADJ
dti-1301	172	10	retention	retention	NOUN
dti-1301	172	11	,	,	PUNCT
dti-1301	172	12	including	include	VERB
dti-1301	172	13	bioadhesive	bioadhesive	ADJ
dti-1301	172	14	systems	system	NOUN
dti-1301	172	15	,	,	PUNCT
dti-1301	172	16	gastric	gastric	ADJ
dti-1301	172	17	swellable	swellable	ADJ
dti-1301	172	18	systems	system	NOUN
dti-1301	172	19	,	,	PUNCT
dti-1301	172	20	density	density	NOUN
dti-1301	172	21	controlled	control	VERB
dti-1301	172	22	systems	system	NOUN
dti-1301	172	23	that	that	PRON
dti-1301	172	24	fl	fl	NUM
dti-1301	172	25	oat	oat	NOUN
dti-1301	172	26	or	or	CCONJ
dti-1301	172	27	sink	sink	VERB
dti-1301	172	28	in	in	ADP
dti-1301	172	29	gastric	gastric	PROPN
dti-1301	172	30	fl	fl	PROPN
dti-1301	172	31	uid	uid	ADJ
dti-1301	172	32	and	and	CCONJ
dti-1301	172	33	magnetic	magnetic	ADJ
dti-1301	172	34	systems	system	NOUN
dti-1301	172	35	that	that	PRON
dti-1301	172	36	require	require	VERB
dti-1301	172	37	positioning	positioning	NOUN
dti-1301	172	38	of	of	ADP
dti-1301	172	39	an	an	DET
dti-1301	172	40	external	external	ADJ
dti-1301	172	41	magnet	magnet	NOUN
dti-1301	172	42	.	.	PUNCT
dti-1301	173	1	each	each	PRON
dti-1301	173	2	of	of	ADP
dti-1301	173	3	the	the	DET
dti-1301	173	4	above	above	ADJ
dti-1301	173	5	techniques	technique	NOUN
dti-1301	173	6	face	face	VERB
dti-1301	173	7	their	their	PRON
dti-1301	173	8	own	own	ADJ
dti-1301	173	9	challenges	challenge	NOUN
dti-1301	173	10	such	such	ADJ
dti-1301	173	11	as	as	ADP
dti-1301	173	12	the	the	DET
dti-1301	173	13	high	high	ADJ
dti-1301	173	14	turnover	turnover	NOUN
dti-1301	173	15	rate	rate	NOUN
dti-1301	173	16	of	of	ADP
dti-1301	173	17	gastric	gastric	ADJ
dti-1301	173	18	mucus	mucus	NOUN
dti-1301	173	19	for	for	ADP
dti-1301	173	20	bioadhesive	bioadhesive	ADJ
dti-1301	173	21	systems	system	NOUN
dti-1301	173	22	,	,	PUNCT
dti-1301	173	23	the	the	DET
dti-1301	173	24	low	low	ADJ
dti-1301	173	25	-	-	PUNCT
dti-1301	173	26	density	density	NOUN
dti-1301	173	27	fl	fl	NOUN
dti-1301	173	28	oating	oate	VERB
dti-1301	173	29	systems	system	NOUN
dti-1301	173	30	are	be	AUX
dti-1301	173	31	dependent	dependent	ADJ
dti-1301	173	32	on	on	ADP
dti-1301	173	33	the	the	DET
dti-1301	173	34	fl	fl	PROPN
dti-1301	173	35	uid	uid	ADJ
dti-1301	173	36	volume	volume	NOUN
dti-1301	173	37	in	in	ADP
dti-1301	173	38	the	the	DET
dti-1301	173	39	stomach	stomach	NOUN
dti-1301	173	40	and	and	CCONJ
dti-1301	173	41	magnetic	magnetic	ADJ
dti-1301	173	42	systems	system	NOUN
dti-1301	173	43	require	require	VERB
dti-1301	173	44	accurate	accurate	ADJ
dti-1301	173	45	external	external	ADJ
dti-1301	173	46	magnet	magnet	NOUN
dti-1301	173	47	positioning	positioning	NOUN
dti-1301	173	48	that	that	SCONJ
dti-1301	173	49	patients	patient	NOUN
dti-1301	173	50	may	may	AUX
dti-1301	173	51	not	not	PART
dti-1301	173	52	be	be	AUX
dti-1301	173	53	able	able	ADJ
dti-1301	173	54	to	to	PART
dti-1301	173	55	comply	comply	VERB
dti-1301	173	56	with	with	ADP
dti-1301	173	57	(	(	PUNCT
dti-1301	173	58	bardonnet	bardonnet	VERB
dti-1301	173	59	et	et	PROPN
dti-1301	173	60	al	al	PROPN
dti-1301	173	61	.	.	PROPN
dti-1301	173	62	2006	2006	NUM
dti-1301	173	63	;	;	PUNCT
dti-1301	173	64	streubel	streubel	VERB
dti-1301	173	65	et	et	PROPN
dti-1301	173	66	al	al	PROPN
dti-1301	173	67	.	.	PROPN
dti-1301	173	68	2006	2006	NUM
dti-1301	173	69	)	)	PUNCT
dti-1301	173	70	.	.	PUNCT
dti-1301	174	1	enteric	enteric	ADJ
dti-1301	174	2	coating	coating	NOUN
dti-1301	174	3	enteric	enteric	NOUN
dti-1301	174	4	coating	coating	NOUN
dti-1301	174	5	is	be	AUX
dti-1301	174	6	employed	employ	VERB
dti-1301	174	7	to	to	PART
dti-1301	174	8	delay	delay	VERB
dti-1301	174	9	release	release	NOUN
dti-1301	174	10	of	of	ADP
dti-1301	174	11	the	the	DET
dti-1301	174	12	active	active	ADJ
dti-1301	174	13	ingredient	ingredient	NOUN
dti-1301	174	14	until	until	SCONJ
dti-1301	174	15	it	it	PRON
dti-1301	174	16	reaches	reach	VERB
dti-1301	174	17	the	the	DET
dti-1301	174	18	small	small	ADJ
dti-1301	174	19	intestine	intestine	NOUN
dti-1301	174	20	.	.	PUNCT
dti-1301	175	1	this	this	DET
dti-1301	175	2	coating	coating	NOUN
dti-1301	175	3	technique	technique	NOUN
dti-1301	175	4	has	have	AUX
dti-1301	175	5	been	be	AUX
dti-1301	175	6	used	use	VERB
dti-1301	175	7	to	to	PART
dti-1301	175	8	release	release	VERB
dti-1301	175	9	drugs	drug	NOUN
dti-1301	175	10	in	in	ADP
dti-1301	175	11	the	the	DET
dti-1301	175	12	small	small	ADJ
dti-1301	175	13	intestine	intestine	NOUN
dti-1301	175	14	such	such	ADJ
dti-1301	175	15	as	as	ADP
dti-1301	175	16	aspirin	aspirin	NOUN
dti-1301	175	17	in	in	ADP
dti-1301	175	18	order	order	NOUN
dti-1301	175	19	to	to	PART
dti-1301	175	20	reduce	reduce	VERB
dti-1301	175	21	gastric	gastric	ADJ
dti-1301	175	22	irritation	irritation	NOUN
dti-1301	175	23	and	and	CCONJ
dti-1301	175	24	erythromycin	erythromycin	NOUN
dti-1301	175	25	that	that	PRON
dti-1301	175	26	exhibits	exhibit	VERB
dti-1301	175	27	acid	acid	NOUN
dti-1301	175	28	degradation	degradation	NOUN
dti-1301	175	29	.	.	PUNCT
dti-1301	176	1	various	various	ADJ
dti-1301	176	2	polymers	polymer	NOUN
dti-1301	176	3	have	have	AUX
dti-1301	176	4	been	be	AUX
dti-1301	176	5	used	use	VERB
dti-1301	176	6	as	as	ADP
dti-1301	176	7	enteric	enteric	ADJ
dti-1301	176	8	polymers	polymer	NOUN
dti-1301	176	9	that	that	PRON
dti-1301	176	10	become	become	VERB
dti-1301	176	11	“	"	PUNCT
dti-1301	176	12	soluble	soluble	ADJ
dti-1301	176	13	”	"	PUNCT
dti-1301	176	14	once	once	ADV
dti-1301	176	15	the	the	DET
dti-1301	176	16	ph	ph	NOUN
dti-1301	176	17	of	of	ADP
dti-1301	176	18	the	the	DET
dti-1301	176	19	environment	environment	NOUN
dti-1301	176	20	reaches	reach	VERB
dti-1301	176	21	the	the	DET
dti-1301	176	22	range	range	NOUN
dti-1301	176	23	between	between	ADP
dti-1301	176	24	5	5	NUM
dti-1301	176	25	and	and	CCONJ
dti-1301	176	26	7	7	NUM
dti-1301	176	27	.	.	PUNCT
dti-1301	177	1	polymers	polymer	NOUN
dti-1301	177	2	that	that	PRON
dti-1301	177	3	degrade	degrade	VERB
dti-1301	177	4	above	above	ADP
dti-1301	177	5	a	a	DET
dti-1301	177	6	ph	ph	NOUN
dti-1301	177	7	of	of	ADP
dti-1301	177	8	7	7	NUM
dti-1301	177	9	have	have	AUX
dti-1301	177	10	been	be	AUX
dti-1301	177	11	used	use	VERB
dti-1301	177	12	in	in	ADP
dti-1301	177	13	an	an	DET
dti-1301	177	14	attempt	attempt	NOUN
dti-1301	177	15	to	to	PART
dti-1301	177	16	target	target	VERB
dti-1301	177	17	colonic	colonic	ADJ
dti-1301	177	18	drug	drug	NOUN
dti-1301	177	19	delivery	delivery	NOUN
dti-1301	177	20	in	in	ADP
dti-1301	177	21	diseases	disease	NOUN
dti-1301	177	22	such	such	ADJ
dti-1301	177	23	as	as	ADP
dti-1301	177	24	colitis	colitis	NOUN
dti-1301	177	25	(	(	PUNCT
dti-1301	177	26	gibaldi	gibaldi	NOUN
dti-1301	177	27	,	,	PUNCT
dti-1301	177	28	1984	1984	NUM
dti-1301	177	29	)	)	PUNCT
dti-1301	177	30	.	.	PUNCT
dti-1301	178	1	however	however	ADV
dti-1301	178	2	,	,	PUNCT
dti-1301	178	3	the	the	DET
dti-1301	178	4	use	use	NOUN
dti-1301	178	5	of	of	ADP
dti-1301	178	6	enteric	enteric	ADJ
dti-1301	178	7	coating	coating	NOUN
dti-1301	178	8	to	to	PART
dti-1301	178	9	obtain	obtain	VERB
dti-1301	178	10	colonic	colonic	ADJ
dti-1301	178	11	delivery	delivery	NOUN
dti-1301	178	12	has	have	AUX
dti-1301	178	13	been	be	AUX
dti-1301	178	14	reported	report	VERB
dti-1301	178	15	to	to	PART
dti-1301	178	16	be	be	AUX
dti-1301	178	17	less	less	ADV
dti-1301	178	18	successful	successful	ADJ
dti-1301	178	19	(	(	PUNCT
dti-1301	178	20	basit	basit	PROPN
dti-1301	178	21	et	et	PROPN
dti-1301	178	22	al	al	PROPN
dti-1301	178	23	.	.	PROPN
dti-1301	178	24	2004	2004	NUM
dti-1301	178	25	)	)	PUNCT
dti-1301	178	26	.	.	PUNCT
dti-1301	179	1	magnesium	magnesium	NOUN
dti-1301	179	2	chloride	chloride	NOUN
dti-1301	179	3	is	be	AUX
dti-1301	179	4	an	an	DET
dti-1301	179	5	example	example	NOUN
dti-1301	179	6	of	of	ADP
dti-1301	179	7	a	a	DET
dti-1301	179	8	compound	compound	NOUN
dti-1301	179	9	that	that	PRON
dti-1301	179	10	is	be	AUX
dti-1301	179	11	prone	prone	ADJ
dti-1301	179	12	to	to	ADP
dti-1301	179	13	gastric	gastric	ADJ
dti-1301	179	14	irritation	irritation	NOUN
dti-1301	179	15	due	due	ADP
dti-1301	179	16	to	to	ADP
dti-1301	179	17	excessive	excessive	ADJ
dti-1301	179	18	formation	formation	NOUN
dti-1301	179	19	of	of	ADP
dti-1301	179	20	hydrochloric	hydrochloric	ADJ
dti-1301	179	21	acid	acid	NOUN
dti-1301	179	22	in	in	ADP
dti-1301	179	23	the	the	DET
dti-1301	179	24	stomach	stomach	NOUN
dti-1301	179	25	when	when	SCONJ
dti-1301	179	26	formulated	formulate	VERB
dti-1301	179	27	into	into	ADP
dti-1301	179	28	immediate	immediate	ADJ
dti-1301	179	29	release	release	NOUN
dti-1301	179	30	products	product	NOUN
dti-1301	179	31	.	.	PUNCT
dti-1301	180	1	magnesium	magnesium	NOUN
dti-1301	180	2	is	be	AUX
dti-1301	180	3	actively	actively	ADV
dti-1301	180	4	absorbed	absorb	VERB
dti-1301	180	5	from	from	ADP
dti-1301	180	6	the	the	DET
dti-1301	180	7	small	small	ADJ
dti-1301	180	8	intestine	intestine	NOUN
dti-1301	180	9	(	(	PUNCT
dti-1301	180	10	reynolds	reynold	NOUN
dti-1301	180	11	,	,	PUNCT
dti-1301	180	12	1993	1993	NUM
dti-1301	180	13	)	)	PUNCT
dti-1301	180	14	and	and	CCONJ
dti-1301	180	15	attempts	attempt	NOUN
dti-1301	180	16	have	have	AUX
dti-1301	180	17	been	be	AUX
dti-1301	180	18	made	make	VERB
dti-1301	180	19	to	to	PART
dti-1301	180	20	target	target	VERB
dti-1301	180	21	this	this	DET
dti-1301	180	22	area	area	NOUN
dti-1301	180	23	by	by	ADP
dti-1301	180	24	means	mean	NOUN
dti-1301	180	25	of	of	ADP
dti-1301	180	26	enteric	enteric	ADJ
dti-1301	180	27	coating	coating	NOUN
dti-1301	180	28	.	.	PUNCT
dti-1301	181	1	the	the	DET
dti-1301	181	2	targeting	targeting	NOUN
dti-1301	181	3	of	of	ADP
dti-1301	181	4	the	the	DET
dti-1301	181	5	proximal	proximal	ADJ
dti-1301	181	6	regions	region	NOUN
dti-1301	181	7	of	of	ADP
dti-1301	181	8	the	the	DET
dti-1301	181	9	small	small	ADJ
dti-1301	181	10	intestine	intestine	NOUN
dti-1301	181	11	by	by	ADP
dti-1301	181	12	enteric	enteric	ADJ
dti-1301	181	13	coating	coating	NOUN
dti-1301	181	14	has	have	AUX
dti-1301	181	15	,	,	PUNCT
dti-1301	181	16	however	however	ADV
dti-1301	181	17	,	,	PUNCT
dti-1301	181	18	been	be	AUX
dti-1301	181	19	criticized	criticize	VERB
dti-1301	181	20	because	because	SCONJ
dti-1301	181	21	release	release	NOUN
dti-1301	181	22	of	of	ADP
dti-1301	181	23	the	the	DET
dti-1301	181	24	active	active	ADJ
dti-1301	181	25	ingredient	ingredient	NOUN
dti-1301	181	26	may	may	AUX
dti-1301	181	27	only	only	ADV
dti-1301	181	28	occur	occur	VERB
dti-1301	181	29	1–2	1–2	NUM
dti-1301	181	30	hours	hour	NOUN
dti-1301	181	31	after	after	ADP
dti-1301	181	32	expulsion	expulsion	NOUN
dti-1301	181	33	from	from	ADP
dti-1301	181	34	the	the	DET
dti-1301	181	35	stomach	stomach	NOUN
dti-1301	181	36	(	(	PUNCT
dti-1301	181	37	basit	basit	PROPN
dti-1301	181	38	et	et	PROPN
dti-1301	181	39	al	al	PROPN
dti-1301	181	40	.	.	PROPN
dti-1301	181	41	2004	2004	NUM
dti-1301	181	42	)	)	PUNCT
dti-1301	181	43	.	.	PUNCT
dti-1301	182	1	this	this	PRON
dti-1301	182	2	suggests	suggest	VERB
dti-1301	182	3	release	release	NOUN
dti-1301	182	4	of	of	ADP
dti-1301	182	5	the	the	DET
dti-1301	182	6	drug	drug	NOUN
dti-1301	182	7	in	in	ADP
dti-1301	182	8	the	the	DET
dti-1301	182	9	distal	distal	ADJ
dti-1301	182	10	parts	part	NOUN
dti-1301	182	11	of	of	ADP
dti-1301	182	12	the	the	DET
dti-1301	182	13	small	small	ADJ
dti-1301	182	14	intestine	intestine	NOUN
dti-1301	182	15	.	.	PUNCT
dti-1301	183	1	another	another	DET
dti-1301	183	2	potential	potential	ADJ
dti-1301	183	3	drawback	drawback	NOUN
dti-1301	183	4	is	be	AUX
dti-1301	183	5	that	that	SCONJ
dti-1301	183	6	enteric	enteric	ADJ
dti-1301	183	7	coated	coated	ADJ
dti-1301	183	8	tablets	tablet	NOUN
dti-1301	183	9	may	may	AUX
dti-1301	183	10	be	be	AUX
dti-1301	183	11	retained	retain	VERB
dti-1301	183	12	in	in	ADP
dti-1301	183	13	the	the	DET
dti-1301	183	14	stomach	stomach	NOUN
dti-1301	183	15	for	for	ADP
dti-1301	183	16	an	an	DET
dti-1301	183	17	extended	extended	ADJ
dti-1301	183	18	period	period	NOUN
dti-1301	183	19	of	of	ADP
dti-1301	183	20	time	time	NOUN
dti-1301	183	21	when	when	SCONJ
dti-1301	183	22	taken	take	VERB
dti-1301	183	23	with	with	ADP
dti-1301	183	24	a	a	DET
dti-1301	183	25	heavy	heavy	ADJ
dti-1301	183	26	breakfast	breakfast	NOUN
dti-1301	183	27	(	(	PUNCT
dti-1301	183	28	friend	friend	NOUN
dti-1301	183	29	,	,	PUNCT
dti-1301	183	30	2005	2005	NUM
dti-1301	183	31	)	)	PUNCT
dti-1301	183	32	.	.	PUNCT
dti-1301	184	1	ranitidine	ranitidine	PROPN
dti-1301	184	2	was	be	AUX
dti-1301	184	3	used	use	VERB
dti-1301	184	4	as	as	ADP
dti-1301	184	5	a	a	DET
dti-1301	184	6	model	model	NOUN
dti-1301	184	7	drug	drug	NOUN
dti-1301	184	8	to	to	PART
dti-1301	184	9	investigate	investigate	VERB
dti-1301	184	10	differences	difference	NOUN
dti-1301	184	11	in	in	ADP
dti-1301	184	12	the	the	DET
dti-1301	184	13	bioavailability	bioavailability	NOUN
dti-1301	184	14	when	when	SCONJ
dti-1301	184	15	administered	administer	VERB
dti-1301	184	16	in	in	ADP
dti-1301	184	17	the	the	DET
dti-1301	184	18	form	form	NOUN
dti-1301	184	19	of	of	ADP
dti-1301	184	20	immediate	immediate	ADJ
dti-1301	184	21	release	release	NOUN
dti-1301	184	22	,	,	PUNCT
dti-1301	184	23	enteric	enteric	ADJ
dti-1301	184	24	coated	coated	ADJ
dti-1301	184	25	and	and	CCONJ
dti-1301	184	26	colon	colon	NOUN
dti-1301	184	27	targeted	target	VERB
dti-1301	184	28	delivery	delivery	NOUN
dti-1301	184	29	systems	system	NOUN
dti-1301	184	30	.	.	PUNCT
dti-1301	185	1	the	the	DET
dti-1301	185	2	absolute	absolute	ADJ
dti-1301	185	3	mean	mean	ADJ
dti-1301	185	4	bioavailability	bioavailability	NOUN
dti-1301	185	5	of	of	ADP
dti-1301	185	6	ranitidine	ranitidine	NOUN
dti-1301	185	7	was	be	AUX
dti-1301	185	8	found	find	VERB
dti-1301	185	9	to	to	PART
dti-1301	185	10	be	be	AUX
dti-1301	185	11	statistically	statistically	ADV
dti-1301	185	12	similar	similar	ADJ
dti-1301	185	13	for	for	ADP
dti-1301	185	14	the	the	DET
dti-1301	185	15	immediate	immediate	ADJ
dti-1301	185	16	and	and	CCONJ
dti-1301	185	17	enteric	enteric	ADJ
dti-1301	185	18	coated	coated	ADJ
dti-1301	185	19	formulations	formulation	NOUN
dti-1301	185	20	,	,	PUNCT
dti-1301	185	21	while	while	SCONJ
dti-1301	185	22	it	it	PRON
dti-1301	185	23	was	be	AUX
dti-1301	185	24	much	much	ADV
dti-1301	185	25	lower	low	ADJ
dti-1301	185	26	for	for	ADP
dti-1301	185	27	the	the	DET
dti-1301	185	28	colonic	colonic	ADJ
dti-1301	185	29	release	release	NOUN
dti-1301	185	30	formulation	formulation	NOUN
dti-1301	185	31	.	.	PUNCT
dti-1301	186	1	this	this	PRON
dti-1301	186	2	was	be	AUX
dti-1301	186	3	despite	despite	SCONJ
dti-1301	186	4	the	the	DET
dti-1301	186	5	fact	fact	NOUN
dti-1301	186	6	that	that	SCONJ
dti-1301	186	7	effective	effective	ADJ
dti-1301	186	8	colonic	colonic	NOUN
dti-1301	186	9	release	release	NOUN
dti-1301	186	10	was	be	AUX
dti-1301	186	11	demonstrated	demonstrate	VERB
dti-1301	186	12	which	which	PRON
dti-1301	186	13	was	be	AUX
dti-1301	186	14	achieved	achieve	VERB
dti-1301	186	15	by	by	ADP
dti-1301	186	16	using	use	VERB
dti-1301	186	17	a	a	DET
dti-1301	186	18	mixture	mixture	NOUN
dti-1301	186	19	of	of	ADP
dti-1301	186	20	amylose	amylose	NOUN
dti-1301	186	21	and	and	CCONJ
dti-1301	186	22	ethylcellose	ethylcellose	PROPN
dti-1301	186	23	.	.	PUNCT
dti-1301	187	1	amylose	amylose	PROPN
dti-1301	187	2	is	be	AUX
dti-1301	187	3	susceptible	susceptible	ADJ
dti-1301	187	4	to	to	ADP
dti-1301	187	5	degradation	degradation	NOUN
dti-1301	187	6	by	by	ADP
dti-1301	187	7	amylase	amylase	NOUN
dti-1301	187	8	producing	produce	VERB
dti-1301	187	9	bacteria	bacteria	NOUN
dti-1301	187	10	that	that	PRON
dti-1301	187	11	reside	reside	VERB
dti-1301	187	12	in	in	ADP
dti-1301	187	13	the	the	DET
dti-1301	187	14	colon	colon	NOUN
dti-1301	187	15	(	(	PUNCT
dti-1301	187	16	basit	basit	PROPN
dti-1301	187	17	et	et	PROPN
dti-1301	187	18	al	al	PROPN
dti-1301	187	19	.	.	PROPN
dti-1301	187	20	2004	2004	NUM
dti-1301	187	21	)	)	PUNCT
dti-1301	187	22	.	.	PUNCT
dti-1301	188	1	in	in	ADP
dti-1301	188	2	this	this	DET
dti-1301	188	3	case	case	NOUN
dti-1301	188	4	the	the	DET
dti-1301	188	5	poor	poor	ADJ
dti-1301	188	6	colonic	colonic	ADJ
dti-1301	188	7	bioavailability	bioavailability	NOUN
dti-1301	188	8	of	of	ADP
dti-1301	188	9	ranitidine	ranitidine	NOUN
dti-1301	188	10	was	be	AUX
dti-1301	188	11	ascribed	ascribe	VERB
dti-1301	188	12	to	to	AUX
dti-1301	188	13	colonic	colonic	VERB
dti-1301	188	14	bacterial	bacterial	ADJ
dti-1301	188	15	metabolism	metabolism	NOUN
dti-1301	188	16	(	(	PUNCT
dti-1301	188	17	friend	friend	NOUN
dti-1301	188	18	,	,	PUNCT
dti-1301	188	19	2005	2005	NUM
dti-1301	188	20	)	)	PUNCT
dti-1301	188	21	.	.	PUNCT
dti-1301	189	1	colonic	colonic	NOUN
dti-1301	189	2	delivery	delivery	NOUN
dti-1301	189	3	targeting	targeting	NOUN
dti-1301	189	4	of	of	ADP
dti-1301	189	5	the	the	DET
dti-1301	189	6	colon	colon	NOUN
dti-1301	189	7	as	as	ADP
dti-1301	189	8	a	a	DET
dti-1301	189	9	site	site	NOUN
dti-1301	189	10	of	of	ADP
dti-1301	189	11	absorption	absorption	NOUN
dti-1301	189	12	has	have	AUX
dti-1301	189	13	recently	recently	ADV
dti-1301	189	14	received	receive	VERB
dti-1301	189	15	attention	attention	NOUN
dti-1301	189	16	by	by	ADP
dti-1301	189	17	various	various	ADJ
dti-1301	189	18	authors	author	NOUN
dti-1301	189	19	because	because	SCONJ
dti-1301	189	20	of	of	ADP
dti-1301	189	21	its	its	PRON
dti-1301	189	22	favorable	favorable	ADJ
dti-1301	189	23	properties	property	NOUN
dti-1301	189	24	particularly	particularly	ADV
dti-1301	189	25	for	for	ADP
dti-1301	189	26	the	the	DET
dti-1301	189	27	absorption	absorption	NOUN
dti-1301	189	28	of	of	ADP
dti-1301	189	29	peptide	peptide	ADJ
dti-1301	189	30	drugs	drug	NOUN
dti-1301	189	31	,	,	PUNCT
dti-1301	189	32	proteins	protein	NOUN
dti-1301	189	33	and	and	CCONJ
dti-1301	189	34	biotechnical	biotechnical	ADJ
dti-1301	189	35	molecules	molecule	NOUN
dti-1301	189	36	(	(	PUNCT
dti-1301	189	37	weidner	weidner	NOUN
dti-1301	189	38	,	,	PUNCT
dti-1301	189	39	2001	2001	NUM
dti-1301	189	40	,	,	PUNCT
dti-1301	189	41	gazzaniga	gazzaniga	NOUN
dti-1301	189	42	et	et	PROPN
dti-1301	189	43	al	al	PROPN
dti-1301	189	44	.	.	PROPN
dti-1301	189	45	2006	2006	NUM
dti-1301	189	46	)	)	PUNCT
dti-1301	189	47	.	.	PUNCT
dti-1301	190	1	some	some	PRON
dti-1301	190	2	of	of	ADP
dti-1301	190	3	the	the	DET
dti-1301	190	4	advantages	advantage	NOUN
dti-1301	190	5	of	of	ADP
dti-1301	190	6	colonic	colonic	ADJ
dti-1301	190	7	delivery	delivery	NOUN
dti-1301	190	8	for	for	ADP
dti-1301	190	9	these	these	DET
dti-1301	190	10	types	type	NOUN
dti-1301	190	11	of	of	ADP
dti-1301	190	12	drugs	drug	NOUN
dti-1301	190	13	include	include	VERB
dti-1301	190	14	the	the	DET
dti-1301	190	15	reduced	reduce	VERB
dti-1301	190	16	concentration	concentration	NOUN
dti-1301	190	17	of	of	ADP
dti-1301	190	18	enzymes	enzyme	NOUN
dti-1301	190	19	such	such	ADJ
dti-1301	190	20	as	as	ADP
dti-1301	190	21	peptidases	peptidase	NOUN
dti-1301	190	22	that	that	PRON
dti-1301	190	23	degrade	degrade	VERB
dti-1301	190	24	peptide	peptide	ADJ
dti-1301	190	25	drugs	drug	NOUN
dti-1301	190	26	,	,	PUNCT
dti-1301	190	27	the	the	DET
dti-1301	190	28	colon	colon	NOUN
dti-1301	190	29	is	be	AUX
dti-1301	190	30	a	a	DET
dti-1301	190	31	site	site	NOUN
dti-1301	190	32	with	with	ADP
dti-1301	190	33	significant	significant	ADJ
dti-1301	190	34	absorption	absorption	NOUN
dti-1301	190	35	due	due	ADP
dti-1301	190	36	to	to	ADP
dti-1301	190	37	the	the	DET
dti-1301	190	38	long	long	ADJ
dti-1301	190	39	drug	drug	NOUN
dti-1301	190	40	target	target	NOUN
dti-1301	190	41	insights	insight	NOUN
dti-1301	190	42	2007	2007	NUM
dti-1301	190	43	:	:	PUNCT
dti-1301	190	44	2	2	NUM
dti-1301	190	45	79	79	NUM
dti-1301	190	46	targeted	target	VERB
dti-1301	190	47	oral	oral	ADJ
dti-1301	190	48	drug	drug	NOUN
dti-1301	190	49	delivery	delivery	NOUN
dti-1301	190	50	residence	residence	NOUN
dti-1301	190	51	time	time	NOUN
dti-1301	190	52	in	in	ADP
dti-1301	190	53	this	this	DET
dti-1301	190	54	part	part	NOUN
dti-1301	190	55	of	of	ADP
dti-1301	190	56	the	the	DET
dti-1301	190	57	gastrointestinal	gastrointestinal	ADJ
dti-1301	190	58	tract	tract	NOUN
dti-1301	190	59	,	,	PUNCT
dti-1301	190	60	it	it	PRON
dti-1301	190	61	exhibits	exhibit	VERB
dti-1301	190	62	enhanced	enhanced	ADJ
dti-1301	190	63	sensitivity	sensitivity	NOUN
dti-1301	190	64	to	to	ADP
dti-1301	190	65	absorption	absorption	NOUN
dti-1301	190	66	enhancers	enhancer	NOUN
dti-1301	190	67	,	,	PUNCT
dti-1301	190	68	demonstrates	demonstrate	VERB
dti-1301	190	69	natural	natural	ADJ
dti-1301	190	70	absorptive	absorptive	ADJ
dti-1301	190	71	characteristics	characteristic	NOUN
dti-1301	190	72	and	and	CCONJ
dti-1301	190	73	the	the	DET
dti-1301	190	74	abundance	abundance	NOUN
dti-1301	190	75	of	of	ADP
dti-1301	190	76	lymphoid	lymphoid	ADJ
dti-1301	190	77	tissue	tissue	NOUN
dti-1301	190	78	follicles	follicle	NOUN
dti-1301	190	79	may	may	AUX
dti-1301	190	80	be	be	AUX
dti-1301	190	81	responsible	responsible	ADJ
dti-1301	190	82	for	for	ADP
dti-1301	190	83	macromolecule	macromolecule	ADJ
dti-1301	190	84	uptake	uptake	NOUN
dti-1301	190	85	(	(	PUNCT
dti-1301	190	86	weidner	weidner	NOUN
dti-1301	190	87	,	,	PUNCT
dti-1301	190	88	2001	2001	NUM
dti-1301	190	89	,	,	PUNCT
dti-1301	190	90	hamman	hamman	PROPN
dti-1301	190	91	et	et	PROPN
dti-1301	190	92	al	al	PROPN
dti-1301	190	93	.	.	PROPN
dti-1301	190	94	2005	2005	NUM
dti-1301	190	95	,	,	PUNCT
dti-1301	190	96	gazzaniga	gazzaniga	NOUN
dti-1301	190	97	et	et	PROPN
dti-1301	190	98	al	al	PROPN
dti-1301	190	99	.	.	PROPN
dti-1301	190	100	2006	2006	NUM
dti-1301	190	101	)	)	PUNCT
dti-1301	190	102	.	.	PUNCT
dti-1301	191	1	the	the	DET
dti-1301	191	2	colon	colon	NOUN
dti-1301	191	3	has	have	AUX
dti-1301	191	4	been	be	AUX
dti-1301	191	5	used	use	VERB
dti-1301	191	6	as	as	ADP
dti-1301	191	7	a	a	DET
dti-1301	191	8	target	target	NOUN
dti-1301	191	9	for	for	ADP
dti-1301	191	10	treatment	treatment	NOUN
dti-1301	191	11	of	of	ADP
dti-1301	191	12	conditions	condition	NOUN
dti-1301	191	13	that	that	PRON
dti-1301	191	14	affect	affect	VERB
dti-1301	191	15	this	this	DET
dti-1301	191	16	part	part	NOUN
dti-1301	191	17	of	of	ADP
dti-1301	191	18	the	the	DET
dti-1301	191	19	gastrointestinal	gastrointestinal	ADJ
dti-1301	191	20	tract	tract	NOUN
dti-1301	191	21	such	such	ADJ
dti-1301	191	22	as	as	ADP
dti-1301	191	23	ulcerative	ulcerative	ADJ
dti-1301	191	24	colitis	colitis	NOUN
dti-1301	191	25	,	,	PUNCT
dti-1301	191	26	crohn	crohn	PROPN
dti-1301	191	27	’s	’s	PART
dti-1301	191	28	disease	disease	NOUN
dti-1301	191	29	and	and	CCONJ
dti-1301	191	30	adenocarcinoma	adenocarcinoma	PROPN
dti-1301	191	31	(	(	PUNCT
dti-1301	191	32	weidner	weidner	NOUN
dti-1301	191	33	,	,	PUNCT
dti-1301	191	34	2001	2001	NUM
dti-1301	191	35	,	,	PUNCT
dti-1301	191	36	gazzaniga	gazzaniga	NOUN
dti-1301	191	37	et	et	PROPN
dti-1301	191	38	al	al	PROPN
dti-1301	191	39	.	.	PROPN
dti-1301	191	40	2006	2006	NUM
dti-1301	191	41	)	)	PUNCT
dti-1301	191	42	.	.	PUNCT
dti-1301	192	1	colonic	colonic	NOUN
dti-1301	192	2	targeting	targeting	NOUN
dti-1301	192	3	has	have	AUX
dti-1301	192	4	been	be	AUX
dti-1301	192	5	studied	study	VERB
dti-1301	192	6	using	use	VERB
dti-1301	192	7	various	various	ADJ
dti-1301	192	8	formulation	formulation	NOUN
dti-1301	192	9	techniques	technique	NOUN
dti-1301	192	10	such	such	ADJ
dti-1301	192	11	as	as	ADP
dti-1301	192	12	reservoir	reservoir	NOUN
dti-1301	192	13	systems	system	NOUN
dti-1301	192	14	with	with	ADP
dti-1301	192	15	rupturable	rupturable	ADJ
dti-1301	192	16	,	,	PUNCT
dti-1301	192	17	erodible-	erodible-	ADJ
dti-1301	192	18	,	,	PUNCT
dti-1301	192	19	diffusive	diffusive	ADJ
dti-1301	192	20	polymeric	polymeric	ADJ
dti-1301	192	21	coats	coat	NOUN
dti-1301	192	22	,	,	PUNCT
dti-1301	192	23	release	release	VERB
dti-1301	192	24	controlling	control	VERB
dti-1301	192	25	polymeric	polymeric	ADJ
dti-1301	192	26	plugs	plug	NOUN
dti-1301	192	27	and	and	CCONJ
dti-1301	192	28	osmotic	osmotic	ADJ
dti-1301	192	29	systems	system	NOUN
dti-1301	192	30	.	.	PUNCT
dti-1301	193	1	currently	currently	ADV
dti-1301	193	2	only	only	ADV
dti-1301	193	3	micro	micro	ADJ
dti-1301	193	4	fl	fl	PROPN
dti-1301	193	5	ora-	ora-	ADJ
dti-1301	193	6	,	,	PUNCT
dti-1301	193	7	ph	ph	ADJ
dti-1301	193	8	dependent	dependent	ADJ
dti-1301	193	9	pressureand	pressureand	NOUN
dti-1301	193	10	time	time	NOUN
dti-1301	193	11	controlled	control	VERB
dti-1301	193	12	technologies	technology	NOUN
dti-1301	193	13	are	be	AUX
dti-1301	193	14	available	available	ADJ
dti-1301	193	15	on	on	ADP
dti-1301	193	16	the	the	DET
dti-1301	193	17	market	market	NOUN
dti-1301	193	18	.	.	PUNCT
dti-1301	194	1	potential	potential	ADJ
dti-1301	194	2	problems	problem	NOUN
dti-1301	194	3	associated	associate	VERB
dti-1301	194	4	with	with	ADP
dti-1301	194	5	some	some	PRON
dti-1301	194	6	of	of	ADP
dti-1301	194	7	the	the	DET
dti-1301	194	8	above	above	ADJ
dti-1301	194	9	systems	system	NOUN
dti-1301	194	10	include	include	VERB
dti-1301	194	11	intraand	intraand	NOUN
dti-1301	194	12	inter	inter	ADJ
dti-1301	194	13	-	-	ADJ
dti-1301	194	14	subject	subject	ADJ
dti-1301	194	15	intestinal	intestinal	ADJ
dti-1301	194	16	ph	ph	NOUN
dti-1301	194	17	variability	variability	NOUN
dti-1301	194	18	,	,	PUNCT
dti-1301	194	19	physiological	physiological	ADJ
dti-1301	194	20	fl	fl	PROPN
dti-1301	194	21	uctuation	uctuation	NOUN
dti-1301	194	22	and	and	CCONJ
dti-1301	194	23	disease	disease	NOUN
dti-1301	194	24	conditions	condition	NOUN
dti-1301	194	25	.	.	PUNCT
dti-1301	195	1	micro	micro	ADJ
dti-1301	195	2	flora	flora	PROPN
dti-1301	195	3	imbalances	imbalance	NOUN
dti-1301	195	4	due	due	ADP
dti-1301	195	5	to	to	ADP
dti-1301	195	6	diet	diet	NOUN
dti-1301	195	7	and	and	CCONJ
dti-1301	195	8	habit	habit	NOUN
dti-1301	195	9	changes	change	NOUN
dti-1301	195	10	are	be	AUX
dti-1301	195	11	also	also	ADV
dti-1301	195	12	a	a	DET
dti-1301	195	13	cause	cause	NOUN
dti-1301	195	14	for	for	ADP
dti-1301	195	15	concern	concern	NOUN
dti-1301	195	16	when	when	SCONJ
dti-1301	195	17	targeting	target	VERB
dti-1301	195	18	the	the	DET
dti-1301	195	19	colon	colon	NOUN
dti-1301	195	20	particularly	particularly	ADV
dti-1301	195	21	when	when	SCONJ
dti-1301	195	22	using	use	VERB
dti-1301	195	23	systems	system	NOUN
dti-1301	195	24	based	base	VERB
dti-1301	195	25	on	on	ADP
dti-1301	195	26	metabolism	metabolism	NOUN
dti-1301	195	27	of	of	ADP
dti-1301	195	28	coatings	coating	NOUN
dti-1301	195	29	for	for	ADP
dti-1301	195	30	colonic	colonic	ADJ
dti-1301	195	31	delivery	delivery	NOUN
dti-1301	195	32	.	.	PUNCT
dti-1301	196	1	most	most	ADJ
dti-1301	196	2	of	of	ADP
dti-1301	196	3	these	these	DET
dti-1301	196	4	disadvantages	disadvantage	NOUN
dti-1301	196	5	can	can	AUX
dti-1301	196	6	be	be	AUX
dti-1301	196	7	circumvented	circumvent	VERB
dti-1301	196	8	by	by	ADP
dti-1301	196	9	using	use	VERB
dti-1301	196	10	time	time	NOUN
dti-1301	196	11	-	-	PUNCT
dti-1301	196	12	controlled	control	VERB
dti-1301	196	13	systems	system	NOUN
dti-1301	196	14	(	(	PUNCT
dti-1301	196	15	gazzaniga	gazzaniga	NOUN
dti-1301	196	16	et	et	PROPN
dti-1301	196	17	al	al	PROPN
dti-1301	196	18	.	.	PROPN
dti-1301	196	19	2006	2006	NUM
dti-1301	196	20	)	)	PUNCT
dti-1301	196	21	,	,	PUNCT
dti-1301	196	22	however	however	ADV
dti-1301	196	23	in	in	SCONJ
dti-1301	196	24	patients	patient	NOUN
dti-1301	196	25	with	with	ADP
dti-1301	196	26	irritable	irritable	ADJ
dti-1301	196	27	bowl	bowl	NOUN
dti-1301	196	28	syndrome	syndrome	NOUN
dti-1301	196	29	intestinal	intestinal	ADJ
dti-1301	196	30	transit	transit	NOUN
dti-1301	196	31	times	time	NOUN
dti-1301	196	32	can	can	AUX
dti-1301	196	33	vary	vary	VERB
dti-1301	196	34	from	from	ADP
dti-1301	196	35	those	those	PRON
dti-1301	196	36	observed	observe	VERB
dti-1301	196	37	in	in	ADP
dti-1301	196	38	healthy	healthy	ADJ
dti-1301	196	39	subjects	subject	NOUN
dti-1301	196	40	and	and	CCONJ
dti-1301	196	41	patients	patient	NOUN
dti-1301	196	42	with	with	ADP
dti-1301	196	43	ulcerative	ulcerative	ADJ
dti-1301	196	44	colitis	colitis	NOUN
dti-1301	196	45	commonly	commonly	ADV
dti-1301	196	46	experience	experience	NOUN
dti-1301	196	47	diarrhea	diarrhea	NOUN
dti-1301	196	48	(	(	PUNCT
dti-1301	196	49	friend	friend	NOUN
dti-1301	196	50	,	,	PUNCT
dti-1301	196	51	2005	2005	NUM
dti-1301	196	52	)	)	PUNCT
dti-1301	196	53	.	.	PUNCT
dti-1301	197	1	specialized	specialized	ADJ
dti-1301	197	2	delivery	delivery	NOUN
dti-1301	197	3	systems	system	NOUN
dti-1301	197	4	superporous	superporous	ADJ
dti-1301	197	5	hydrogels	hydrogel	NOUN
dti-1301	197	6	and	and	CCONJ
dti-1301	197	7	composites	composite	NOUN
dti-1301	197	8	thereof	thereof	ADV
dti-1301	197	9	have	have	AUX
dti-1301	197	10	been	be	AUX
dti-1301	197	11	described	describe	VERB
dti-1301	197	12	for	for	ADP
dti-1301	197	13	use	use	NOUN
dti-1301	197	14	in	in	ADP
dti-1301	197	15	specialized	specialized	ADJ
dti-1301	197	16	systems	system	NOUN
dti-1301	197	17	designed	design	VERB
dti-1301	197	18	for	for	ADP
dti-1301	197	19	the	the	DET
dti-1301	197	20	delivery	delivery	NOUN
dti-1301	197	21	of	of	ADP
dti-1301	197	22	peptide	peptide	ADJ
dti-1301	197	23	drug	drug	NOUN
dti-1301	197	24	.	.	PUNCT
dti-1301	198	1	they	they	PRON
dti-1301	198	2	swell	swell	VERB
dti-1301	198	3	very	very	ADV
dti-1301	198	4	quickly	quickly	ADV
dti-1301	198	5	and	and	CCONJ
dti-1301	198	6	mechanically	mechanically	ADV
dti-1301	198	7	interact	interact	VERB
dti-1301	198	8	with	with	ADP
dti-1301	198	9	intestinal	intestinal	ADJ
dti-1301	198	10	membranes	membrane	NOUN
dti-1301	198	11	at	at	ADP
dti-1301	198	12	the	the	DET
dti-1301	198	13	specifi	specifi	PROPN
dti-1301	198	14	c	c	PROPN
dti-1301	198	15	site	site	NOUN
dti-1301	198	16	of	of	ADP
dti-1301	198	17	absorption	absorption	NOUN
dti-1301	198	18	.	.	PUNCT
dti-1301	199	1	the	the	DET
dti-1301	199	2	lag	lag	NOUN
dti-1301	199	3	time	time	NOUN
dti-1301	199	4	provided	provide	VERB
dti-1301	199	5	by	by	ADP
dti-1301	199	6	the	the	DET
dti-1301	199	7	system	system	NOUN
dti-1301	199	8	enables	enable	VERB
dti-1301	199	9	drug	drug	NOUN
dti-1301	199	10	release	release	NOUN
dti-1301	199	11	from	from	ADP
dti-1301	199	12	the	the	DET
dti-1301	199	13	core	core	NOUN
dti-1301	199	14	to	to	PART
dti-1301	199	15	achieve	achieve	VERB
dti-1301	199	16	optimal	optimal	ADJ
dti-1301	199	17	absorption	absorption	NOUN
dti-1301	199	18	(	(	PUNCT
dti-1301	199	19	dorkoosh	dorkoosh	NOUN
dti-1301	199	20	et	et	PROPN
dti-1301	199	21	al	al	PROPN
dti-1301	199	22	.	.	PROPN
dti-1301	199	23	2001	2001	NUM
dti-1301	199	24	)	)	PUNCT
dti-1301	199	25	.	.	PUNCT
dti-1301	200	1	other	other	ADJ
dti-1301	200	2	specialized	specialized	ADJ
dti-1301	200	3	dosage	dosage	NOUN
dti-1301	200	4	forms	form	NOUN
dti-1301	200	5	include	include	VERB
dti-1301	200	6	particulate	particulate	NOUN
dti-1301	200	7	systems	system	NOUN
dti-1301	200	8	that	that	PRON
dti-1301	200	9	are	be	AUX
dti-1301	200	10	designed	design	VERB
dti-1301	200	11	to	to	PART
dti-1301	200	12	protect	protect	VERB
dti-1301	200	13	the	the	DET
dti-1301	200	14	drug	drug	NOUN
dti-1301	200	15	against	against	ADP
dti-1301	200	16	enzymatic	enzymatic	ADJ
dti-1301	200	17	degradation	degradation	NOUN
dti-1301	200	18	and	and	CCONJ
dti-1301	200	19	to	to	PART
dti-1301	200	20	provide	provide	VERB
dti-1301	200	21	a	a	DET
dti-1301	200	22	high	high	ADJ
dti-1301	200	23	transfer	transfer	NOUN
dti-1301	200	24	rate	rate	NOUN
dti-1301	200	25	of	of	ADP
dti-1301	200	26	drug	drug	NOUN
dti-1301	200	27	across	across	ADP
dti-1301	200	28	the	the	DET
dti-1301	200	29	epithelial	epithelial	ADJ
dti-1301	200	30	mucosa	mucosa	NOUN
dti-1301	200	31	.	.	PUNCT
dti-1301	201	1	some	some	DET
dti-1301	201	2	particulate	particulate	NOUN
dti-1301	201	3	systems	system	NOUN
dti-1301	201	4	are	be	AUX
dti-1301	201	5	capable	capable	ADJ
dti-1301	201	6	of	of	ADP
dti-1301	201	7	being	be	AUX
dti-1301	201	8	taken	take	VERB
dti-1301	201	9	up	up	ADP
dti-1301	201	10	through	through	ADP
dti-1301	201	11	peyer	peyer	NOUN
dti-1301	201	12	’s	’s	PART
dti-1301	201	13	patches	patch	NOUN
dti-1301	201	14	without	without	ADP
dti-1301	201	15	addition	addition	NOUN
dti-1301	201	16	of	of	ADP
dti-1301	201	17	absorption	absorption	NOUN
dti-1301	201	18	enhancers	enhancer	NOUN
dti-1301	201	19	.	.	PUNCT
dti-1301	202	1	these	these	DET
dti-1301	202	2	systems	system	NOUN
dti-1301	202	3	include	include	VERB
dti-1301	202	4	nanoparticles	nanoparticle	NOUN
dti-1301	202	5	,	,	PUNCT
dti-1301	202	6	liposomes	liposome	NOUN
dti-1301	202	7	,	,	PUNCT
dti-1301	202	8	microspheres	microsphere	NOUN
dti-1301	202	9	and	and	CCONJ
dti-1301	202	10	lipid	lipid	NOUN
dti-1301	202	11	based	base	VERB
dti-1301	202	12	systems	system	NOUN
dti-1301	202	13	.	.	PUNCT
dti-1301	203	1	despite	despite	SCONJ
dti-1301	203	2	increased	increase	VERB
dti-1301	203	3	oral	oral	ADJ
dti-1301	203	4	peptide	peptide	NOUN
dti-1301	203	5	delivery	delivery	NOUN
dti-1301	203	6	with	with	ADP
dti-1301	203	7	modifi	modifi	NOUN
dti-1301	203	8	ed	ed	PROPN
dti-1301	203	9	liposomes	liposome	NOUN
dti-1301	203	10	,	,	PUNCT
dti-1301	203	11	solid	solid	ADJ
dti-1301	203	12	particles	particle	NOUN
dti-1301	203	13	appear	appear	VERB
dti-1301	203	14	to	to	PART
dti-1301	203	15	be	be	AUX
dti-1301	203	16	more	more	ADV
dti-1301	203	17	effective	effective	ADJ
dti-1301	203	18	for	for	ADP
dti-1301	203	19	the	the	DET
dti-1301	203	20	delivery	delivery	NOUN
dti-1301	203	21	of	of	ADP
dti-1301	203	22	hydrophilic	hydrophilic	ADJ
dti-1301	203	23	macromolecules	macromolecule	NOUN
dti-1301	203	24	(	(	PUNCT
dti-1301	203	25	morishita	morishita	NOUN
dti-1301	203	26	and	and	CCONJ
dti-1301	203	27	peppas	peppa	NOUN
dti-1301	203	28	,	,	PUNCT
dti-1301	203	29	2006	2006	NUM
dti-1301	203	30	)	)	PUNCT
dti-1301	203	31	.	.	PUNCT
dti-1301	204	1	nano	nano	NOUN
dti-1301	204	2	-	-	PUNCT
dti-1301	204	3	sized	sized	ADJ
dti-1301	204	4	particles	particle	NOUN
dti-1301	204	5	such	such	ADJ
dti-1301	204	6	as	as	ADP
dti-1301	204	7	chitosan	chitosan	NOUN
dti-1301	204	8	-	-	PUNCT
dti-1301	204	9	coated	coat	VERB
dti-1301	204	10	nanoparticles	nanoparticle	NOUN
dti-1301	204	11	have	have	AUX
dti-1301	204	12	illustrated	illustrate	VERB
dti-1301	204	13	limited	limited	ADJ
dti-1301	204	14	success	success	NOUN
dti-1301	204	15	as	as	ADP
dti-1301	204	16	peptide	peptide	NOUN
dti-1301	204	17	delivery	delivery	NOUN
dti-1301	204	18	systems	system	NOUN
dti-1301	204	19	.	.	PUNCT
dti-1301	205	1	these	these	DET
dti-1301	205	2	systems	system	NOUN
dti-1301	205	3	have	have	AUX
dti-1301	205	4	also	also	ADV
dti-1301	205	5	been	be	AUX
dti-1301	205	6	linked	link	VERB
dti-1301	205	7	to	to	ADP
dti-1301	205	8	ligands	ligand	NOUN
dti-1301	205	9	to	to	PART
dti-1301	205	10	target	target	VERB
dti-1301	205	11	specifi	specifi	PROPN
dti-1301	205	12	c	c	PROPN
dti-1301	205	13	absorption	absorption	NOUN
dti-1301	205	14	carriers	carrier	NOUN
dti-1301	205	15	,	,	PUNCT
dti-1301	205	16	however	however	ADV
dti-1301	205	17	,	,	PUNCT
dti-1301	205	18	these	these	DET
dti-1301	205	19	types	type	NOUN
dti-1301	205	20	of	of	ADP
dti-1301	205	21	systems	system	NOUN
dti-1301	205	22	still	still	ADV
dti-1301	205	23	have	have	VERB
dti-1301	205	24	serious	serious	ADJ
dti-1301	205	25	problems	problem	NOUN
dti-1301	205	26	with	with	ADP
dti-1301	205	27	the	the	DET
dti-1301	205	28	manufacturing	manufacturing	NOUN
dti-1301	205	29	process	process	NOUN
dti-1301	205	30	and	and	CCONJ
dti-1301	205	31	safety	safety	NOUN
dti-1301	205	32	issues	issue	NOUN
dti-1301	205	33	such	such	ADJ
dti-1301	205	34	as	as	ADP
dti-1301	205	35	accumulation	accumulation	NOUN
dti-1301	205	36	of	of	ADP
dti-1301	205	37	the	the	DET
dti-1301	205	38	carrier	carrier	NOUN
dti-1301	205	39	in	in	ADP
dti-1301	205	40	tissues	tissue	NOUN
dti-1301	205	41	(	(	PUNCT
dti-1301	205	42	hamman	hamman	PROPN
dti-1301	205	43	et	et	PROPN
dti-1301	205	44	al	al	PROPN
dti-1301	205	45	.	.	PROPN
dti-1301	205	46	2005	2005	NUM
dti-1301	205	47	,	,	PUNCT
dti-1301	205	48	morishita	morishita	NOUN
dti-1301	205	49	and	and	CCONJ
dti-1301	205	50	peppas	peppa	NOUN
dti-1301	205	51	,	,	PUNCT
dti-1301	205	52	2006	2006	NUM
dti-1301	205	53	)	)	PUNCT
dti-1301	205	54	.	.	PUNCT
dti-1301	206	1	examples	example	NOUN
dti-1301	206	2	of	of	ADP
dti-1301	206	3	marketed	market	VERB
dti-1301	206	4	drug	drug	NOUN
dti-1301	206	5	products	product	NOUN
dti-1301	206	6	and	and	CCONJ
dti-1301	206	7	drugs	drug	NOUN
dti-1301	206	8	under	under	ADP
dti-1301	206	9	investigation	investigation	NOUN
dti-1301	206	10	are	be	AUX
dti-1301	206	11	listed	list	VERB
dti-1301	206	12	in	in	ADP
dti-1301	206	13	table	table	NOUN
dti-1301	206	14	1	1	NUM
dti-1301	206	15	.	.	PUNCT
dti-1301	207	1	references	reference	NOUN
dti-1301	207	2	ambudkar	ambudkar	NOUN
dti-1301	207	3	,	,	PUNCT
dti-1301	207	4	s.v	s.v	PROPN
dti-1301	207	5	.	.	PROPN
dti-1301	207	6	,	,	PUNCT
dti-1301	207	7	kim	kim	PROPN
dti-1301	207	8	,	,	PUNCT
dti-1301	207	9	i	i	PROPN
dti-1301	207	10	-	-	PUNCT
dti-1301	207	11	w.	w.	PROPN
dti-1301	207	12	and	and	CCONJ
dti-1301	207	13	sauna	sauna	PROPN
dti-1301	207	14	,	,	PUNCT
dti-1301	207	15	z.e	z.e	PROPN
dti-1301	207	16	.	.	PROPN
dti-1301	207	17	2006	2006	NUM
dti-1301	207	18	.	.	PUNCT
dti-1301	208	1	the	the	DET
dti-1301	208	2	power	power	NOUN
dti-1301	208	3	of	of	ADP
dti-1301	208	4	the	the	DET
dti-1301	208	5	pump	pump	NOUN
dti-1301	208	6	:	:	PUNCT
dti-1301	208	7	mechanisms	mechanism	NOUN
dti-1301	208	8	of	of	ADP
dti-1301	208	9	action	action	NOUN
dti-1301	208	10	of	of	ADP
dti-1301	208	11	p	p	NOUN
dti-1301	208	12	-	-	PUNCT
dti-1301	208	13	glycoprotein	glycoprotein	NOUN
dti-1301	208	14	(	(	PUNCT
dti-1301	208	15	abcb1	abcb1	NOUN
dti-1301	208	16	)	)	PUNCT
dti-1301	208	17	.	.	PUNCT
dti-1301	209	1	eur	eur	PROPN
dti-1301	209	2	.	.	PUNCT
dti-1301	210	1	j.	j.	PROPN
dti-1301	210	2	pharm	pharm	PROPN
dti-1301	210	3	.	.	PUNCT
dti-1301	211	1	sci	sci	PROPN
dti-1301	211	2	.	.	PROPN
dti-1301	211	3	,	,	PUNCT
dti-1301	212	1	27:392–400	27:392–400	PROPN
dti-1301	212	2	.	.	PUNCT
dti-1301	213	1	aungst	aungst	PROPN
dti-1301	213	2	,	,	PUNCT
dti-1301	213	3	b.j	b.j	PROPN
dti-1301	213	4	.	.	PROPN
dti-1301	213	5	1993	1993	NUM
dti-1301	213	6	.	.	PUNCT
dti-1301	214	1	novel	novel	ADJ
dti-1301	214	2	formulation	formulation	NOUN
dti-1301	214	3	strategies	strategy	NOUN
dti-1301	214	4	for	for	ADP
dti-1301	214	5	improving	improve	VERB
dti-1301	214	6	oral	oral	ADJ
dti-1301	214	7	bioavailability	bioavailability	NOUN
dti-1301	214	8	of	of	ADP
dti-1301	214	9	drugs	drug	NOUN
dti-1301	214	10	with	with	ADP
dti-1301	214	11	poor	poor	ADJ
dti-1301	214	12	membrane	membrane	NOUN
dti-1301	214	13	permeation	permeation	NOUN
dti-1301	214	14	or	or	CCONJ
dti-1301	214	15	presystemic	presystemic	ADJ
dti-1301	214	16	metabolism	metabolism	NOUN
dti-1301	214	17	.	.	PUNCT
dti-1301	215	1	j.	j.	PROPN
dti-1301	215	2	pharm	pharm	PROPN
dti-1301	215	3	.	.	PUNCT
dti-1301	216	1	sci	sci	PROPN
dti-1301	216	2	.	.	PROPN
dti-1301	216	3	,	,	PUNCT
dti-1301	216	4	82(10):979–87	82(10):979–87	PROPN
dti-1301	216	5	.	.	PUNCT
dti-1301	217	1	aungst	aungst	PROPN
dti-1301	217	2	,	,	PUNCT
dti-1301	217	3	b.j	b.j	PROPN
dti-1301	217	4	.	.	PROPN
dti-1301	217	5	2000	2000	NUM
dti-1301	217	6	.	.	PUNCT
dti-1301	218	1	intestinal	intestinal	ADJ
dti-1301	218	2	permeation	permeation	NOUN
dti-1301	218	3	enhancers	enhancer	NOUN
dti-1301	218	4	.	.	PUNCT
dti-1301	219	1	j.	j.	PROPN
dti-1301	219	2	pharm	pharm	PROPN
dti-1301	219	3	.	.	PUNCT
dti-1301	220	1	sci	sci	PROPN
dti-1301	220	2	.	.	PROPN
dti-1301	220	3	,	,	PUNCT
dti-1301	220	4	89(4):429–42	89(4):429–42	NUM
dti-1301	220	5	.	.	PUNCT
dti-1301	221	1	banerjee	banerjee	PROPN
dti-1301	221	2	,	,	PUNCT
dti-1301	221	3	d.	d.	PROPN
dti-1301	221	4	,	,	PUNCT
dti-1301	221	5	flanagan	flanagan	PROPN
dti-1301	221	6	,	,	PUNCT
dti-1301	221	7	p.r	p.r	PROPN
dti-1301	221	8	.	.	PROPN
dti-1301	221	9	and	and	CCONJ
dti-1301	221	10	cluett	cluett	PROPN
dti-1301	221	11	,	,	PUNCT
dti-1301	221	12	j.	j.	PROPN
dti-1301	221	13	et	et	PROPN
dti-1301	221	14	al	al	PROPN
dti-1301	221	15	.	.	PROPN
dti-1301	221	16	1986	1986	NUM
dti-1301	221	17	.	.	PUNCT
dti-1301	222	1	transferrin	transferrin	NOUN
dti-1301	222	2	receptors	receptor	NOUN
dti-1301	222	3	in	in	ADP
dti-1301	222	4	the	the	DET
dti-1301	222	5	human	human	ADJ
dti-1301	222	6	gastrointestinal	gastrointestinal	ADJ
dti-1301	222	7	tract	tract	NOUN
dti-1301	222	8	.	.	PUNCT
dti-1301	223	1	gastroenterology	gastroenterology	NOUN
dti-1301	223	2	,	,	PUNCT
dti-1301	223	3	91:861–9	91:861–9	NUM
dti-1301	223	4	.	.	PUNCT
dti-1301	224	1	bardonnet	bardonnet	PROPN
dti-1301	224	2	,	,	PUNCT
dti-1301	224	3	p.l	p.l	PROPN
dti-1301	224	4	.	.	PROPN
dti-1301	224	5	,	,	PUNCT
dti-1301	224	6	faive	faive	ADJ
dti-1301	224	7	,	,	PUNCT
dti-1301	224	8	v.	v.	PROPN
dti-1301	224	9	and	and	CCONJ
dti-1301	224	10	pugh	pugh	PROPN
dti-1301	224	11	,	,	PUNCT
dti-1301	224	12	w.j	w.j	PROPN
dti-1301	224	13	.	.	PROPN
dti-1301	224	14	et	et	PROPN
dti-1301	224	15	al	al	PROPN
dti-1301	224	16	.	.	PROPN
dti-1301	224	17	2006	2006	NUM
dti-1301	224	18	.	.	PUNCT
dti-1301	225	1	gastroretentive	gastroretentive	ADJ
dti-1301	225	2	dosage	dosage	NOUN
dti-1301	225	3	forms	form	NOUN
dti-1301	225	4	:	:	PUNCT
dti-1301	225	5	overview	overview	NOUN
dti-1301	225	6	and	and	CCONJ
dti-1301	225	7	special	special	ADJ
dti-1301	225	8	case	case	NOUN
dti-1301	225	9	of	of	ADP
dti-1301	225	10	helicobacter	helicobacter	NOUN
dti-1301	225	11	pilori	pilori	NOUN
dti-1301	225	12	.	.	PUNCT
dti-1301	226	1	j.	j.	PROPN
dti-1301	226	2	control	control	PROPN
dti-1301	226	3	release	release	PROPN
dti-1301	226	4	,	,	PUNCT
dti-1301	226	5	111:1–18	111:1–18	NUM
dti-1301	226	6	.	.	PUNCT
dti-1301	226	7	drug	drug	NOUN
dti-1301	226	8	formulation	formulation	NOUN
dti-1301	226	9	trade	trade	NOUN
dti-1301	226	10	name	name	NOUN
dti-1301	226	11	mesalamine	mesalamine	NOUN
dti-1301	226	12	eudragit	eudragit	PROPN
dti-1301	226	13	-	-	PUNCT
dti-1301	226	14	s/-l	s/-l	ADJ
dti-1301	226	15	coated	coated	ADJ
dti-1301	226	16	tablets	tablet	NOUN
dti-1301	226	17	asacol	asacol	PROPN
dti-1301	226	18	®	®	NOUN
dti-1301	226	19	/salofac	/salofac	NOUN
dti-1301	226	20	®	®	NOUN
dti-1301	226	21	budesonide	budesonide	NOUN
dti-1301	226	22	eudragit	eudragit	ADJ
dti-1301	226	23	-	-	PUNCT
dti-1301	226	24	l	l	NOUN
dti-1301	226	25	coated	coated	ADJ
dti-1301	226	26	beads	bead	NOUN
dti-1301	226	27	entocort	entocort	NOUN
dti-1301	226	28	®	®	NOUN
dti-1301	226	29	acetazolamide	acetazolamide	ADV
dti-1301	226	30	sustained	sustain	VERB
dti-1301	226	31	release	release	NOUN
dti-1301	226	32	capsules	capsule	NOUN
dti-1301	226	33	diamox	diamox	PROPN
dti-1301	226	34	sa	sa	PROPN
dti-1301	226	35	®	®	NOUN
dti-1301	226	36	aminophyline	aminophyline	NOUN
dti-1301	226	37	matrix	matrix	NOUN
dti-1301	226	38	tablets	tablet	NOUN
dti-1301	226	39	pecram	pecram	NOUN
dti-1301	226	40	®	®	NOUN
dti-1301	226	41	aspirin	aspirin	NOUN
dti-1301	226	42	enteric	enteric	ADJ
dti-1301	226	43	coated	coated	ADJ
dti-1301	226	44	tablets	tablet	NOUN
dti-1301	226	45	caprin	caprin	NOUN
dti-1301	226	46	®	®	NOUN
dti-1301	226	47	carbamazepine	carbamazepine	NOUN
dti-1301	226	48	modifi	modifi	PROPN
dti-1301	226	49	ed	ed	PROPN
dti-1301	226	50	release	release	PROPN
dti-1301	226	51	tablet	tablet	NOUN
dti-1301	226	52	tegretol	tegretol	PROPN
dti-1301	226	53	retard	retard	PROPN
dti-1301	226	54	®	®	NOUN
dti-1301	226	55	diclofenac	diclofenac	NOUN
dti-1301	226	56	enteric	enteric	ADJ
dti-1301	226	57	coated	coated	ADJ
dti-1301	226	58	tablets	tablet	NOUN
dti-1301	226	59	voltaren	voltaren	NOUN
dti-1301	226	60	®	®	NOUN
dti-1301	226	61	table	table	NOUN
dti-1301	226	62	1	1	NUM
dti-1301	226	63	.	.	PUNCT
dti-1301	227	1	some	some	DET
dti-1301	227	2	examples	example	NOUN
dti-1301	227	3	of	of	ADP
dti-1301	227	4	drug	drug	NOUN
dti-1301	227	5	products	product	NOUN
dti-1301	227	6	on	on	ADP
dti-1301	227	7	the	the	DET
dti-1301	227	8	market	market	NOUN
dti-1301	227	9	associated	associate	VERB
dti-1301	227	10	with	with	ADP
dti-1301	227	11	targeting	target	VERB
dti-1301	227	12	the	the	DET
dti-1301	227	13	site	site	NOUN
dti-1301	227	14	of	of	ADP
dti-1301	227	15	drug	drug	NOUN
dti-1301	227	16	delivery	delivery	NOUN
dti-1301	227	17	(	(	PUNCT
dti-1301	227	18	lund	lund	NOUN
dti-1301	227	19	,	,	PUNCT
dti-1301	227	20	1994	1994	NUM
dti-1301	227	21	;	;	PUNCT
dti-1301	227	22	friend	friend	NOUN
dti-1301	227	23	,	,	PUNCT
dti-1301	227	24	2005	2005	NUM
dti-1301	227	25	)	)	PUNCT
dti-1301	227	26	.	.	PUNCT
dti-1301	228	1	drug	drug	NOUN
dti-1301	228	2	target	target	NOUN
dti-1301	228	3	insights	insight	NOUN
dti-1301	228	4	2007	2007	NUM
dti-1301	228	5	:	:	PUNCT
dti-1301	228	6	280	280	NUM
dti-1301	228	7	hamman	hamman	NOUN
dti-1301	228	8	et	et	PROPN
dti-1301	228	9	al	al	PROPN
dti-1301	228	10	basit	basit	PROPN
dti-1301	228	11	,	,	PUNCT
dti-1301	228	12	a.w	a.w	PROPN
dti-1301	228	13	.	.	PROPN
dti-1301	228	14	,	,	PUNCT
dti-1301	228	15	podczeck	podczeck	PROPN
dti-1301	228	16	,	,	PUNCT
dti-1301	228	17	f.	f.	PROPN
dti-1301	228	18	and	and	CCONJ
dti-1301	228	19	newton	newton	PROPN
dti-1301	228	20	,	,	PUNCT
dti-1301	228	21	j.m	j.m	PROPN
dti-1301	228	22	.	.	PROPN
dti-1301	228	23	et	et	PROPN
dti-1301	228	24	al	al	PROPN
dti-1301	228	25	.	.	PROPN
dti-1301	228	26	2004	2004	NUM
dti-1301	228	27	.	.	PUNCT
dti-1301	229	1	the	the	DET
dti-1301	229	2	use	use	NOUN
dti-1301	229	3	of	of	ADP
dti-1301	229	4	formulation	formulation	NOUN
dti-1301	229	5	technology	technology	NOUN
dti-1301	229	6	to	to	PART
dti-1301	229	7	assess	assess	VERB
dti-1301	229	8	regional	regional	ADJ
dti-1301	229	9	gastrointestinal	gastrointestinal	ADJ
dti-1301	229	10	drug	drug	NOUN
dti-1301	229	11	absorption	absorption	NOUN
dti-1301	229	12	in	in	ADP
dti-1301	229	13	humans	human	NOUN
dti-1301	229	14	.	.	PUNCT
dti-1301	230	1	eur	eur	PROPN
dti-1301	230	2	.	.	PUNCT
dti-1301	231	1	j.	j.	PROPN
dti-1301	231	2	pharm	pharm	PROPN
dti-1301	231	3	.	.	PUNCT
dti-1301	232	1	sci	sci	PROPN
dti-1301	232	2	.	.	PROPN
dti-1301	232	3	,	,	PUNCT
dti-1301	232	4	21:179–89	21:179–89	NUM
dti-1301	232	5	.	.	PUNCT
dti-1301	233	1	cawley	cawley	NOUN
dti-1301	233	2	,	,	PUNCT
dti-1301	233	3	d.b	d.b	PROPN
dti-1301	233	4	.	.	PROPN
dti-1301	233	5	,	,	PUNCT
dti-1301	233	6	simpson	simpson	PROPN
dti-1301	233	7	,	,	PUNCT
dti-1301	233	8	d.l	d.l	PROPN
dti-1301	233	9	.	.	PROPN
dti-1301	233	10	and	and	CCONJ
dti-1301	233	11	hershman	hershman	PROPN
dti-1301	233	12	,	,	PUNCT
dti-1301	233	13	h.r	h.r	PROPN
dti-1301	233	14	.	.	PROPN
dti-1301	233	15	1981	1981	NUM
dti-1301	233	16	.	.	PUNCT
dti-1301	234	1	asiologlycoprotein	asiologlycoprotein	DET
dti-1301	234	2	receptor	receptor	NOUN
dti-1301	234	3	mediates	mediate	VERB
dti-1301	234	4	the	the	DET
dti-1301	234	5	toxic	toxic	ADJ
dti-1301	234	6	effects	effect	NOUN
dti-1301	234	7	of	of	ADP
dti-1301	234	8	an	an	DET
dti-1301	234	9	asiolofetuin	asiolofetuin	NOUN
dti-1301	234	10	-	-	PUNCT
dti-1301	234	11	diptheria	diptheria	NOUN
dti-1301	234	12	toxin	toxin	NOUN
dti-1301	234	13	fragment	fragment	NOUN
dti-1301	234	14	a	a	DET
dti-1301	234	15	conjugate	conjugate	NOUN
dti-1301	234	16	on	on	ADP
dti-1301	234	17	cultured	cultured	ADJ
dti-1301	234	18	rat	rat	NOUN
dti-1301	234	19	hepatocytes	hepatocyte	NOUN
dti-1301	234	20	.	.	PUNCT
dti-1301	235	1	proc	proc	PROPN
dti-1301	235	2	.	.	PUNCT
dti-1301	236	1	natl	natl	PROPN
dti-1301	236	2	.	.	PUNCT
dti-1301	237	1	acad	acad	PROPN
dti-1301	237	2	.	.	PUNCT
dti-1301	238	1	sci	sci	PROPN
dti-1301	238	2	.	.	PUNCT
dti-1301	238	3	u.s.a	u.s.a	PROPN
dti-1301	238	4	.	.	PROPN
dti-1301	238	5	,	,	PUNCT
dti-1301	238	6	78:3383	78:3383	NUM
dti-1301	238	7	.	.	PUNCT
dti-1301	238	8	dautry	dautry	NOUN
dti-1301	238	9	-	-	PUNCT
dti-1301	238	10	varsat	varsat	NOUN
dti-1301	238	11	,	,	PUNCT
dti-1301	238	12	a.	a.	NOUN
dti-1301	238	13	1986	1986	NUM
dti-1301	238	14	.	.	PUNCT
dti-1301	239	1	receptor	receptor	NOUN
dti-1301	239	2	-	-	PUNCT
dti-1301	239	3	mediated	mediate	VERB
dti-1301	239	4	endocytosis	endocytosis	NOUN
dti-1301	239	5	:	:	PUNCT
dti-1301	239	6	the	the	DET
dti-1301	239	7	intracellular	intracellular	ADJ
dti-1301	239	8	journey	journey	NOUN
dti-1301	239	9	of	of	ADP
dti-1301	239	10	transferrin	transferrin	NOUN
dti-1301	239	11	and	and	CCONJ
dti-1301	239	12	its	its	PRON
dti-1301	239	13	receptor	receptor	NOUN
dti-1301	239	14	.	.	PUNCT
dti-1301	240	1	biochimie	biochimie	PROPN
dti-1301	240	2	.	.	PUNCT
dti-1301	241	1	68:375–81	68:375–81	ADJ
dti-1301	241	2	.	.	PUNCT
dti-1301	242	1	de	de	PROPN
dti-1301	242	2	aizpurua	aizpurua	PROPN
dti-1301	242	3	,	,	PUNCT
dti-1301	242	4	h.j	h.j	PROPN
dti-1301	242	5	.	.	PROPN
dti-1301	242	6	,	,	PUNCT
dti-1301	242	7	burge	burge	NOUN
dti-1301	242	8	,	,	PUNCT
dti-1301	242	9	h.j	h.j	PROPN
dti-1301	242	10	.	.	PROPN
dti-1301	242	11	and	and	CCONJ
dti-1301	242	12	howe	howe	PROPN
dti-1301	242	13	,	,	PUNCT
dti-1301	242	14	p.a	p.a	PROPN
dti-1301	242	15	.	.	PROPN
dti-1301	242	16	et	et	PROPN
dti-1301	242	17	al	al	PROPN
dti-1301	242	18	.	.	PROPN
dti-1301	242	19	1986	1986	NUM
dti-1301	242	20	.	.	PUNCT
dti-1301	243	1	oral	oral	ADJ
dti-1301	243	2	delivery	delivery	NOUN
dti-1301	243	3	system	system	NOUN
dti-1301	243	4	pct	pct	NOUN
dti-1301	243	5	/	/	SYM
dti-1301	243	6	au86/0299	au86/0299	PROPN
dti-1301	243	7	.	.	PUNCT
dti-1301	244	1	de	de	PROPN
dti-1301	244	2	aizpurua	aizpurua	PROPN
dti-1301	244	3	,	,	PUNCT
dti-1301	244	4	h.j	h.j	PROPN
dti-1301	244	5	.	.	PROPN
dti-1301	244	6	and	and	CCONJ
dti-1301	244	7	russel	russel	PROPN
dti-1301	244	8	-	-	PUNCT
dti-1301	244	9	jones	jones	PROPN
dti-1301	244	10	,	,	PUNCT
dti-1301	244	11	g.j	g.j	PROPN
dti-1301	244	12	.	.	PROPN
dti-1301	244	13	1987	1987	NUM
dti-1301	244	14	.	.	PUNCT
dti-1301	245	1	oral	oral	ADJ
dti-1301	245	2	vaccination	vaccination	NOUN
dti-1301	245	3	:	:	PUNCT
dti-1301	245	4	identifi	identifi	PROPN
dti-1301	245	5	cation	cation	NOUN
dti-1301	245	6	of	of	ADP
dti-1301	245	7	classes	class	NOUN
dti-1301	245	8	of	of	ADP
dti-1301	245	9	proteins	protein	NOUN
dti-1301	245	10	which	which	PRON
dti-1301	245	11	provoke	provoke	VERB
dti-1301	245	12	response	response	NOUN
dti-1301	245	13	upon	upon	SCONJ
dti-1301	245	14	oral	oral	ADJ
dti-1301	245	15	feeding	feeding	NOUN
dti-1301	245	16	.	.	PUNCT
dti-1301	246	1	j.	j.	PROPN
dti-1301	246	2	exp	exp	PROPN
dti-1301	246	3	.	.	PROPN
dti-1301	246	4	med	med	PROPN
dti-1301	246	5	.	.	PROPN
dti-1301	246	6	,	,	PUNCT
dti-1301	246	7	167:440–51	167:440–51	NUM
dti-1301	246	8	.	.	PUNCT
dti-1301	247	1	dorkoosh	dorkoosh	NOUN
dti-1301	247	2	,	,	PUNCT
dti-1301	247	3	f.a	f.a	PROPN
dti-1301	247	4	.	.	PROPN
dti-1301	247	5	,	,	PUNCT
dti-1301	247	6	verhoef	verhoef	PROPN
dti-1301	247	7	,	,	PUNCT
dti-1301	247	8	j.c	j.c	PROPN
dti-1301	247	9	.	.	PROPN
dti-1301	247	10	and	and	CCONJ
dti-1301	247	11	borchard	borchard	NOUN
dti-1301	247	12	,	,	PUNCT
dti-1301	247	13	g.	g.	PROPN
dti-1301	247	14	et	et	PROPN
dti-1301	248	1	al	al	PROPN
dti-1301	248	2	.	.	PROPN
dti-1301	248	3	2001	2001	NUM
dti-1301	248	4	.	.	PUNCT
dti-1301	249	1	development	development	NOUN
dti-1301	249	2	and	and	CCONJ
dti-1301	249	3	characterization	characterization	NOUN
dti-1301	249	4	of	of	ADP
dti-1301	249	5	a	a	DET
dti-1301	249	6	novel	novel	ADJ
dti-1301	249	7	peroral	peroral	ADJ
dti-1301	249	8	peptide	peptide	NOUN
dti-1301	249	9	drug	drug	NOUN
dti-1301	249	10	delivery	delivery	NOUN
dti-1301	249	11	system	system	NOUN
dti-1301	249	12	.	.	PUNCT
dti-1301	250	1	j.	j.	PROPN
dti-1301	250	2	control	control	PROPN
dti-1301	250	3	release	release	PROPN
dti-1301	250	4	,	,	PUNCT
dti-1301	250	5	17:307–18	17:307–18	NUM
dti-1301	250	6	.	.	PUNCT
dti-1301	251	1	faulk	faulk	PROPN
dti-1301	251	2	,	,	PUNCT
dti-1301	251	3	w.p	w.p	PROPN
dti-1301	251	4	.	.	PROPN
dti-1301	251	5	,	,	PUNCT
dti-1301	251	6	his	his	PRON
dti-1301	251	7	,	,	PUNCT
dti-1301	251	8	b.l	b.l	PROPN
dti-1301	251	9	.	.	PROPN
dti-1301	251	10	and	and	CCONJ
dti-1301	251	11	stevens	stevens	PROPN
dti-1301	251	12	,	,	PUNCT
dti-1301	251	13	p.j	p.j	PROPN
dti-1301	251	14	.	.	PROPN
dti-1301	251	15	1980	1980	NUM
dti-1301	251	16	.	.	PUNCT
dti-1301	252	1	transferrin	transferrin	NOUN
dti-1301	252	2	and	and	CCONJ
dti-1301	252	3	transferrin	transferrin	NOUN
dti-1301	252	4	receptors	receptor	NOUN
dti-1301	252	5	in	in	ADP
dti-1301	252	6	carcinoma	carcinoma	NOUN
dti-1301	252	7	of	of	ADP
dti-1301	252	8	the	the	DET
dti-1301	252	9	breast	breast	NOUN
dti-1301	252	10	.	.	PUNCT
dti-1301	253	1	lancet	lancet	PROPN
dti-1301	253	2	.	.	PUNCT
dti-1301	253	3	,	,	PUNCT
dti-1301	253	4	ii:390–2	ii:390–2	PROPN
dti-1301	253	5	.	.	PUNCT
dti-1301	254	1	féger	féger	PROPN
dti-1301	254	2	,	,	PUNCT
dti-1301	254	3	j.	j.	PROPN
dti-1301	254	4	,	,	PUNCT
dti-1301	254	5	gil	gil	PROPN
dti-1301	254	6	-	-	PUNCT
dti-1301	254	7	falcon	falcon	PROPN
dti-1301	254	8	,	,	PUNCT
dti-1301	254	9	s.	s.	PROPN
dti-1301	254	10	,	,	PUNCT
dti-1301	254	11	lamaze	lamaze	PROPN
dti-1301	254	12	,	,	PUNCT
dti-1301	254	13	c.	c.	PROPN
dti-1301	254	14	1994	1994	NUM
dti-1301	254	15	.	.	PUNCT
dti-1301	255	1	cell	cell	NOUN
dti-1301	255	2	receptors	receptor	NOUN
dti-1301	255	3	:	:	PUNCT
dti-1301	255	4	defi	defi	NOUN
dti-1301	255	5	nition	nition	NOUN
dti-1301	255	6	,	,	PUNCT
dti-1301	255	7	mechanisms	mechanism	NOUN
dti-1301	255	8	and	and	CCONJ
dti-1301	255	9	regulation	regulation	NOUN
dti-1301	255	10	of	of	ADP
dti-1301	255	11	receptor	receptor	NOUN
dti-1301	255	12	-	-	PUNCT
dti-1301	255	13	mediated	mediate	VERB
dti-1301	255	14	endocytosis	endocytosis	NOUN
dti-1301	255	15	.	.	PUNCT
dti-1301	256	1	cell	cell	NOUN
dti-1301	256	2	.	.	PUNCT
dti-1301	257	1	mol	mol	PROPN
dti-1301	257	2	.	.	PUNCT
dti-1301	257	3	biol	biol	PROPN
dti-1301	257	4	.	.	PUNCT
dti-1301	257	5	,	,	PUNCT
dti-1301	258	1	40:1039–61	40:1039–61	X
dti-1301	258	2	.	.	PUNCT
dti-1301	258	3	frieden	frieden	PROPN
dti-1301	258	4	,	,	PUNCT
dti-1301	258	5	p.m.	p.m.	ADV
dti-1301	258	6	,	,	PUNCT
dti-1301	258	7	walus	walus	ADJ
dti-1301	258	8	,	,	PUNCT
dti-1301	258	9	l.r	l.r	PROPN
dti-1301	258	10	.	.	PROPN
dti-1301	258	11	and	and	CCONJ
dti-1301	258	12	musso	musso	PROPN
dti-1301	258	13	,	,	PUNCT
dti-1301	258	14	g.f	g.f	PROPN
dti-1301	258	15	.	.	PROPN
dti-1301	258	16	et	et	PROPN
dti-1301	258	17	al	al	PROPN
dti-1301	258	18	.	.	PROPN
dti-1301	258	19	1991	1991	NUM
dti-1301	258	20	.	.	PUNCT
dti-1301	259	1	anti	anti	ADJ
dti-1301	259	2	-	-	ADJ
dti-1301	259	3	transferrin	transferrin	ADJ
dti-1301	259	4	receptor	receptor	NOUN
dti-1301	259	5	antibody	antibody	NOUN
dti-1301	259	6	and	and	CCONJ
dti-1301	259	7	antibody	antibody	NOUN
dti-1301	259	8	-	-	PUNCT
dti-1301	259	9	conjugates	conjugate	NOUN
dti-1301	259	10	cross	cross	VERB
dti-1301	259	11	the	the	DET
dti-1301	259	12	blood	blood	NOUN
dti-1301	259	13	brain	brain	NOUN
dti-1301	259	14	barrier	barrier	NOUN
dti-1301	259	15	.	.	PUNCT
dti-1301	260	1	proc	proc	PROPN
dti-1301	260	2	.	.	PUNCT
dti-1301	261	1	natl	natl	PROPN
dti-1301	261	2	.	.	PUNCT
dti-1301	262	1	acad	acad	PROPN
dti-1301	262	2	.	.	PUNCT
dti-1301	263	1	sci	sci	PROPN
dti-1301	263	2	.	.	PUNCT
dti-1301	263	3	u.s.a	u.s.a	PROPN
dti-1301	263	4	.	.	PROPN
dti-1301	263	5	,	,	PUNCT
dti-1301	263	6	88:4771–5	88:4771–5	NUM
dti-1301	263	7	.	.	PUNCT
dti-1301	264	1	friend	friend	NOUN
dti-1301	264	2	,	,	PUNCT
dti-1301	264	3	d.r	d.r	PROPN
dti-1301	264	4	.	.	PROPN
dti-1301	264	5	2005	2005	NUM
dti-1301	264	6	.	.	PUNCT
dti-1301	265	1	new	new	ADJ
dti-1301	265	2	oral	oral	ADJ
dti-1301	265	3	delivery	delivery	NOUN
dti-1301	265	4	systems	system	NOUN
dti-1301	265	5	for	for	ADP
dti-1301	265	6	the	the	DET
dti-1301	265	7	treatment	treatment	NOUN
dti-1301	265	8	of	of	ADP
dti-1301	265	9	infl	infl	PROPN
dti-1301	265	10	ammatory	ammatory	NOUN
dti-1301	265	11	bowel	bowel	NOUN
dti-1301	265	12	disease	disease	NOUN
dti-1301	265	13	.	.	PUNCT
dti-1301	266	1	adv	adv	PROPN
dti-1301	266	2	.	.	PUNCT
dti-1301	266	3	drug	drug	PROPN
dti-1301	266	4	deliv	deliv	PROPN
dti-1301	266	5	.	.	PUNCT
dti-1301	267	1	rev	rev	PROPN
dti-1301	267	2	.	.	PROPN
dti-1301	267	3	,	,	PUNCT
dti-1301	267	4	57:247–65	57:247–65	NUM
dti-1301	267	5	.	.	PUNCT
dti-1301	268	1	fyfe	fyfe	PROPN
dti-1301	268	2	,	,	PUNCT
dti-1301	268	3	j.c	j.c	PROPN
dti-1301	268	4	.	.	PROPN
dti-1301	268	5	,	,	PUNCT
dti-1301	268	6	ramanujam	ramanujam	PROPN
dti-1301	268	7	,	,	PUNCT
dti-1301	268	8	j.c	j.c	PROPN
dti-1301	268	9	.	.	PROPN
dti-1301	268	10	and	and	CCONJ
dti-1301	268	11	ramasamy	ramasamy	PROPN
dti-1301	268	12	,	,	PUNCT
dti-1301	268	13	k.s	k.s	PROPN
dti-1301	268	14	.	.	PROPN
dti-1301	268	15	et	et	PROPN
dti-1301	268	16	al	al	PROPN
dti-1301	268	17	.	.	PROPN
dti-1301	268	18	1991	1991	NUM
dti-1301	268	19	.	.	PUNCT
dti-1301	269	1	defective	defective	ADJ
dti-1301	269	2	brush	brush	NOUN
dti-1301	269	3	-	-	PUNCT
dti-1301	269	4	border	border	NOUN
dti-1301	269	5	expression	expression	NOUN
dti-1301	269	6	of	of	ADP
dti-1301	269	7	intrinsic	intrinsic	ADJ
dti-1301	269	8	factor	factor	NOUN
dti-1301	269	9	-	-	PUNCT
dti-1301	269	10	cobalamin	cobalamin	NOUN
dti-1301	269	11	receptor	receptor	NOUN
dti-1301	269	12	in	in	ADP
dti-1301	269	13	canine	canine	NOUN
dti-1301	269	14	inherited	inherit	VERB
dti-1301	269	15	intestinal	intestinal	ADJ
dti-1301	269	16	cobalamin	cobalamin	NOUN
dti-1301	269	17	malabsorption	malabsorption	NOUN
dti-1301	269	18	.	.	PUNCT
dti-1301	270	1	j.	j.	PROPN
dti-1301	270	2	biol	biol	PROPN
dti-1301	270	3	.	.	PUNCT
dti-1301	271	1	chem	chem	PROPN
dti-1301	271	2	.	.	PUNCT
dti-1301	271	3	,	,	PUNCT
dti-1301	272	1	266:4489–94	266:4489–94	X
dti-1301	272	2	.	.	PUNCT
dti-1301	273	1	gabor	gabor	PROPN
dti-1301	273	2	,	,	PUNCT
dti-1301	273	3	f.	f.	PROPN
dti-1301	273	4	,	,	PUNCT
dti-1301	273	5	bogner	bogner	PROPN
dti-1301	273	6	,	,	PUNCT
dti-1301	273	7	e.	e.	PROPN
dti-1301	273	8	,	,	PUNCT
dti-1301	273	9	weissenboeck	weissenboeck	PROPN
dti-1301	273	10	,	,	PUNCT
dti-1301	273	11	a.	a.	PROPN
dti-1301	273	12	et	et	PROPN
dti-1301	273	13	al	al	PROPN
dti-1301	273	14	.	.	PROPN
dti-1301	273	15	2004	2004	NUM
dti-1301	273	16	.	.	PUNCT
dti-1301	274	1	the	the	DET
dti-1301	274	2	lectin	lectin	NOUN
dti-1301	274	3	-	-	PUNCT
dti-1301	274	4	cell	cell	NOUN
dti-1301	274	5	interaction	interaction	NOUN
dti-1301	274	6	and	and	CCONJ
dti-1301	274	7	its	its	PRON
dti-1301	274	8	implications	implication	NOUN
dti-1301	274	9	to	to	ADP
dti-1301	274	10	intestinal	intestinal	ADJ
dti-1301	274	11	lectin	lectin	NOUN
dti-1301	274	12	-	-	PUNCT
dti-1301	274	13	mediated	mediate	VERB
dti-1301	274	14	drug	drug	NOUN
dti-1301	274	15	delivery	delivery	NOUN
dti-1301	274	16	.	.	PUNCT
dti-1301	275	1	adv	adv	PROPN
dti-1301	275	2	.	.	PUNCT
dti-1301	275	3	drug	drug	PROPN
dti-1301	275	4	deliv	deliv	PROPN
dti-1301	275	5	.	.	PUNCT
dti-1301	276	1	rev	rev	PROPN
dti-1301	276	2	.	.	PROPN
dti-1301	276	3	,	,	PUNCT
dti-1301	276	4	56:459–80	56:459–80	PROPN
dti-1301	276	5	.	.	PUNCT
dti-1301	277	1	gazzaniga	gazzaniga	PROPN
dti-1301	277	2	,	,	PUNCT
dti-1301	277	3	a.	a.	NOUN
dti-1301	277	4	,	,	PUNCT
dti-1301	277	5	marconi	marconi	NOUN
dti-1301	277	6	,	,	PUNCT
dti-1301	277	7	a.	a.	NOUN
dti-1301	277	8	and	and	CCONJ
dti-1301	277	9	sangalli	sangalli	NOUN
dti-1301	277	10	,	,	PUNCT
dti-1301	277	11	m.e	m.e	PROPN
dti-1301	277	12	.	.	PROPN
dti-1301	277	13	et	et	PROPN
dti-1301	277	14	al	al	PROPN
dti-1301	277	15	.	.	PROPN
dti-1301	277	16	2006	2006	NUM
dti-1301	277	17	.	.	PUNCT
dti-1301	278	1	time	time	NOUN
dti-1301	278	2	-	-	PUNCT
dti-1301	278	3	controlled	control	VERB
dti-1301	278	4	oral	oral	ADJ
dti-1301	278	5	delivery	delivery	NOUN
dti-1301	278	6	systems	system	NOUN
dti-1301	278	7	for	for	ADP
dti-1301	278	8	colon	colon	NOUN
dti-1301	278	9	targeting	targeting	NOUN
dti-1301	278	10	.	.	PUNCT
dti-1301	279	1	expert	expert	NOUN
dti-1301	279	2	.	.	PUNCT
dti-1301	280	1	opin	opin	NOUN
dti-1301	280	2	.	.	PUNCT
dti-1301	281	1	drug	drug	NOUN
dti-1301	281	2	deliv	deliv	NOUN
dti-1301	281	3	.	.	PUNCT
dti-1301	281	4	,	,	PUNCT
dti-1301	282	1	3(5):583–97	3(5):583–97	X
dti-1301	282	2	.	.	PUNCT
dti-1301	283	1	geuze	geuze	PROPN
dti-1301	283	2	,	,	PUNCT
dti-1301	283	3	j.j	j.j	PROPN
dti-1301	283	4	.	.	PROPN
dti-1301	283	5	,	,	PUNCT
dti-1301	283	6	slot	slot	NOUN
dti-1301	283	7	,	,	PUNCT
dti-1301	283	8	j.w	j.w	PROPN
dti-1301	283	9	.	.	PROPN
dti-1301	283	10	and	and	CCONJ
dti-1301	283	11	strou	strou	PROPN
dti-1301	283	12	,	,	PUNCT
dti-1301	283	13	g.j	g.j	PROPN
dti-1301	283	14	.	.	PROPN
dti-1301	283	15	1983	1983	NUM
dti-1301	283	16	.	.	PUNCT
dti-1301	284	1	intracellular	intracellular	ADJ
dti-1301	284	2	site	site	NOUN
dti-1301	284	3	of	of	ADP
dti-1301	284	4	asiologlycoprotein	asiologlycoprotein	ADJ
dti-1301	284	5	receptor	receptor	NOUN
dti-1301	284	6	-	-	PUNCT
dti-1301	284	7	ligand	ligand	NOUN
dti-1301	284	8	uncoupling	uncoupling	NOUN
dti-1301	284	9	:	:	PUNCT
dti-1301	284	10	double	double	ADJ
dti-1301	284	11	-	-	PUNCT
dti-1301	284	12	label	label	NOUN
dti-1301	284	13	immunoelectronmicroscopy	immunoelectronmicroscopy	NOUN
dti-1301	284	14	during	during	ADP
dti-1301	284	15	receptor	receptor	NOUN
dti-1301	284	16	-	-	PUNCT
dti-1301	284	17	mediated	mediate	VERB
dti-1301	284	18	endocytosis	endocytosis	NOUN
dti-1301	284	19	.	.	PUNCT
dti-1301	285	1	cell	cell	NOUN
dti-1301	285	2	.	.	PUNCT
dti-1301	286	1	35:277–287	35:277–287	NUM
dti-1301	286	2	.	.	PUNCT
dti-1301	287	1	ghilzai	ghilzai	NOUN
dti-1301	287	2	,	,	PUNCT
dti-1301	287	3	m.k	m.k	PROPN
dti-1301	287	4	.	.	PROPN
dti-1301	287	5	2004	2004	NUM
dti-1301	287	6	.	.	PUNCT
dti-1301	288	1	advances	advance	NOUN
dti-1301	288	2	in	in	ADP
dti-1301	288	3	the	the	DET
dti-1301	288	4	delivery	delivery	NOUN
dti-1301	288	5	of	of	ADP
dti-1301	288	6	large	large	ADJ
dti-1301	288	7	-	-	PUNCT
dti-1301	288	8	size	size	NOUN
dti-1301	288	9	drug	drug	NOUN
dti-1301	288	10	molecules	molecule	NOUN
dti-1301	288	11	.	.	PUNCT
dti-1301	289	1	innovations	innovation	NOUN
dti-1301	289	2	in	in	ADP
dti-1301	289	3	pharmaceutical	pharmaceutical	ADJ
dti-1301	289	4	technology	technology	NOUN
dti-1301	289	5	,	,	PUNCT
dti-1301	289	6	jun	jun	PROPN
dti-1301	289	7	.	.	PROPN
dti-1301	289	8	,:103–8	,:103–8	PROPN
dti-1301	289	9	.	.	PUNCT
dti-1301	290	1	gibaldi	gibaldi	NOUN
dti-1301	290	2	,	,	PUNCT
dti-1301	290	3	m.	m.	NOUN
dti-1301	290	4	1984	1984	NUM
dti-1301	290	5	.	.	PUNCT
dti-1301	291	1	gastrointestinal	gastrointestinal	ADJ
dti-1301	291	2	absorption	absorption	NOUN
dti-1301	291	3	—	—	PUNCT
dti-1301	291	4	role	role	NOUN
dti-1301	291	5	of	of	ADP
dti-1301	291	6	the	the	DET
dti-1301	291	7	dosage	dosage	NOUN
dti-1301	291	8	form	form	NOUN
dti-1301	291	9	.	.	PUNCT
dti-1301	292	1	in	in	ADP
dti-1301	292	2	:	:	PUNCT
dti-1301	292	3	biopharmaceutics	biopharmaceutic	NOUN
dti-1301	292	4	and	and	CCONJ
dti-1301	292	5	clinical	clinical	ADJ
dti-1301	292	6	pharmacokinetics	pharmacokinetic	NOUN
dti-1301	292	7	.	.	PUNCT
dti-1301	293	1	3rd	3rd	ADJ
dti-1301	293	2	ed	ed	NOUN
dti-1301	293	3	.	.	PUNCT
dti-1301	294	1	lea	lea	PROPN
dti-1301	294	2	and	and	CCONJ
dti-1301	294	3	febiger	febiger	NOUN
dti-1301	294	4	:	:	PUNCT
dti-1301	294	5	philadelphia	philadelphia	PROPN
dti-1301	294	6	p.	p.	NOUN
dti-1301	295	1	71–3	71–3	PROPN
dti-1301	295	2	.	.	PUNCT
dti-1301	296	1	gomez	gomez	PROPN
dti-1301	296	2	-	-	PUNCT
dti-1301	296	3	orellana	orellana	PROPN
dti-1301	296	4	,	,	PUNCT
dti-1301	296	5	i.	i.	NOUN
dti-1301	296	6	2005	2005	NUM
dti-1301	296	7	.	.	PUNCT
dti-1301	297	1	strategies	strategy	NOUN
dti-1301	297	2	to	to	PART
dti-1301	297	3	improve	improve	VERB
dti-1301	297	4	oral	oral	ADJ
dti-1301	297	5	drug	drug	NOUN
dti-1301	297	6	bioavailability	bioavailability	NOUN
dti-1301	297	7	.	.	PUNCT
dti-1301	298	1	expert	expert	NOUN
dti-1301	298	2	opin	opin	NOUN
dti-1301	298	3	.	.	PUNCT
dti-1301	299	1	drug	drug	NOUN
dti-1301	299	2	deliv	deliv	NOUN
dti-1301	299	3	.	.	PUNCT
dti-1301	299	4	,	,	PUNCT
dti-1301	299	5	2(3):419–33	2(3):419–33	NUM
dti-1301	299	6	.	.	PUNCT
dti-1301	300	1	guéant	guéant	NOUN
dti-1301	300	2	,	,	PUNCT
dti-1301	300	3	j.l	j.l	PROPN
dti-1301	300	4	.	.	PROPN
dti-1301	300	5	,	,	PUNCT
dti-1301	300	6	masson	masson	PROPN
dti-1301	300	7	,	,	PUNCT
dti-1301	300	8	d.	d.	PROPN
dti-1301	300	9	and	and	CCONJ
dti-1301	300	10	schohn	schohn	NOUN
dti-1301	300	11	,	,	PUNCT
dti-1301	300	12	h.	h.	PROPN
dti-1301	300	13	et	et	PROPN
dti-1301	300	14	al	al	PROPN
dti-1301	300	15	.	.	PROPN
dti-1301	300	16	1992	1992	NUM
dti-1301	300	17	.	.	PUNCT
dti-1301	301	1	receptor	receptor	NOUN
dti-1301	301	2	-	-	PUNCT
dti-1301	301	3	mediated	mediate	VERB
dti-1301	301	4	endocytosis	endocytosis	NOUN
dti-1301	301	5	of	of	ADP
dti-1301	301	6	intrinsic	intrinsic	ADJ
dti-1301	301	7	factor	factor	NOUN
dti-1301	301	8	-	-	PUNCT
dti-1301	301	9	cobalamin	cobalamin	NOUN
dti-1301	301	10	complex	complex	NOUN
dti-1301	301	11	in	in	ADP
dti-1301	301	12	ht	ht	PROPN
dti-1301	301	13	29	29	NUM
dti-1301	301	14	,	,	PUNCT
dti-1301	301	15	a	a	DET
dti-1301	301	16	human	human	ADJ
dti-1301	301	17	colon	colon	NOUN
dti-1301	301	18	carcinoma	carcinoma	NOUN
dti-1301	301	19	cell	cell	NOUN
dti-1301	301	20	line	line	NOUN
dti-1301	301	21	.	.	PUNCT
dti-1301	302	1	febs	febs	PROPN
dti-1301	302	2	lett	lett	PROPN
dti-1301	302	3	.	.	PROPN
dti-1301	302	4	,	,	PUNCT
dti-1301	302	5	297:229–32	297:229–32	PROPN
dti-1301	302	6	.	.	PUNCT
dti-1301	303	1	habberfi	habberfi	PROPN
dti-1301	303	2	eld	eld	PROPN
dti-1301	303	3	,	,	PUNCT
dti-1301	303	4	a.	a.	PROPN
dti-1301	303	5	,	,	PUNCT
dti-1301	303	6	jensen	jensen	PROPN
dti-1301	303	7	-	-	PUNCT
dti-1301	303	8	pippo	pippo	PROPN
dti-1301	303	9	,	,	PUNCT
dti-1301	303	10	k.	k.	PROPN
dti-1301	303	11	and	and	CCONJ
dti-1301	303	12	ralph	ralph	PROPN
dti-1301	303	13	,	,	PUNCT
dti-1301	303	14	l.	l.	PROPN
dti-1301	303	15	et	et	PROPN
dti-1301	303	16	al	al	PROPN
dti-1301	303	17	.	.	PROPN
dti-1301	303	18	1995	1995	NUM
dti-1301	303	19	.	.	PUNCT
dti-1301	304	1	vitamin	vitamin	NOUN
dti-1301	304	2	b12mediated	b12mediate	VERB
dti-1301	304	3	uptake	uptake	NOUN
dti-1301	304	4	of	of	ADP
dti-1301	304	5	recombinant	recombinant	ADJ
dti-1301	304	6	therapeutic	therapeutic	ADJ
dti-1301	304	7	proteins	protein	NOUN
dti-1301	304	8	from	from	ADP
dti-1301	304	9	the	the	DET
dti-1301	304	10	gut	gut	NOUN
dti-1301	304	11	.	.	PUNCT
dti-1301	305	1	nature	nature	PROPN
dti-1301	305	2	med	me	VERB
dti-1301	305	3	.	.	PROPN
dti-1301	305	4	,	,	PUNCT
dti-1301	305	5	submitted	submit	VERB
dti-1301	305	6	.	.	PUNCT
dti-1301	306	1	habberfi	habberfi	PROPN
dti-1301	306	2	eld	eld	PROPN
dti-1301	306	3	,	,	PUNCT
dti-1301	306	4	a.	a.	PROPN
dti-1301	306	5	,	,	PUNCT
dti-1301	306	6	jensen	jensen	PROPN
dti-1301	306	7	-	-	PUNCT
dti-1301	306	8	pippo	pippo	PROPN
dti-1301	306	9	,	,	PUNCT
dti-1301	306	10	k.	k.	PROPN
dti-1301	306	11	and	and	CCONJ
dti-1301	306	12	ralph	ralph	PROPN
dti-1301	306	13	,	,	PUNCT
dti-1301	306	14	l.	l.	PROPN
dti-1301	306	15	et	et	PROPN
dti-1301	306	16	al	al	PROPN
dti-1301	306	17	.	.	PROPN
dti-1301	306	18	1996	1996	NUM
dti-1301	306	19	.	.	PUNCT
dti-1301	307	1	vitamin	vitamin	NOUN
dti-1301	307	2	b12mediated	b12mediate	VERB
dti-1301	307	3	uptake	uptake	NOUN
dti-1301	307	4	of	of	ADP
dti-1301	307	5	erythropoietin	erythropoietin	NOUN
dti-1301	307	6	and	and	CCONJ
dti-1301	307	7	granulocyte	granulocyte	ADJ
dti-1301	307	8	colony	colony	NOUN
dti-1301	307	9	stimulating	stimulate	VERB
dti-1301	307	10	factor	factor	NOUN
dti-1301	307	11	in	in	ADP
dti-1301	307	12	vitro	vitro	X
dti-1301	307	13	and	and	CCONJ
dti-1301	307	14	in	in	ADP
dti-1301	307	15	vivo	vivo	NOUN
dti-1301	307	16	.	.	PUNCT
dti-1301	308	1	int	int	NOUN
dti-1301	308	2	.	.	PUNCT
dti-1301	309	1	j.	j.	PROPN
dti-1301	309	2	pharm	pharm	PROPN
dti-1301	309	3	.	.	PUNCT
dti-1301	309	4	,	,	PUNCT
dti-1301	309	5	145:1–8	145:1–8	PROPN
dti-1301	309	6	.	.	PUNCT
dti-1301	310	1	hamman	hamman	PROPN
dti-1301	310	2	,	,	PUNCT
dti-1301	310	3	j.h	j.h	PROPN
dti-1301	310	4	.	.	PROPN
dti-1301	310	5	,	,	PUNCT
dti-1301	310	6	enslin	enslin	PROPN
dti-1301	310	7	,	,	PUNCT
dti-1301	310	8	g.m	g.m	PROPN
dti-1301	310	9	.	.	PROPN
dti-1301	310	10	and	and	CCONJ
dti-1301	310	11	kotze	kotze	PROPN
dti-1301	310	12	,	,	PUNCT
dti-1301	310	13	a.f	a.f	PROPN
dti-1301	310	14	.	.	PROPN
dti-1301	310	15	2005	2005	NUM
dti-1301	310	16	.	.	PUNCT
dti-1301	311	1	oral	oral	ADJ
dti-1301	311	2	delivery	delivery	NOUN
dti-1301	311	3	of	of	ADP
dti-1301	311	4	peptide	peptide	ADJ
dti-1301	311	5	drugs	drug	NOUN
dti-1301	311	6	biodrugs	biodrug	NOUN
dti-1301	311	7	,	,	PUNCT
dti-1301	311	8	19:165–77	19:165–77	NOUN
dti-1301	311	9	.	.	PUNCT
dti-1301	312	1	hidalgo	hidalgo	PROPN
dti-1301	312	2	,	,	PUNCT
dti-1301	312	3	i.j	i.j	PROPN
dti-1301	312	4	.	.	PROPN
dti-1301	312	5	and	and	CCONJ
dti-1301	312	6	li	li	PROPN
dti-1301	312	7	,	,	PUNCT
dti-1301	312	8	j.	j.	PROPN
dti-1301	312	9	1996	1996	NUM
dti-1301	312	10	.	.	PUNCT
dti-1301	313	1	carrier	carrier	NOUN
dti-1301	313	2	-	-	PUNCT
dti-1301	313	3	mediated	mediate	VERB
dti-1301	313	4	transport	transport	NOUN
dti-1301	313	5	and	and	CCONJ
dti-1301	313	6	effl	effl	PROPN
dti-1301	313	7	ux	ux	PROPN
dti-1301	313	8	mechanisms	mechanism	NOUN
dti-1301	313	9	in	in	ADP
dti-1301	313	10	caco-2	caco-2	NUM
dti-1301	313	11	cells	cell	NOUN
dti-1301	313	12	.	.	PUNCT
dti-1301	314	1	adv	adv	PROPN
dti-1301	314	2	.	.	PUNCT
dti-1301	314	3	drug	drug	PROPN
dti-1301	314	4	deliv	deliv	PROPN
dti-1301	314	5	.	.	PUNCT
dti-1301	315	1	rev	rev	PROPN
dti-1301	315	2	.	.	PROPN
dti-1301	315	3	,	,	PUNCT
dti-1301	315	4	22:53–66	22:53–66	PROPN
dti-1301	315	5	.	.	PUNCT
dti-1301	316	1	hunter	hunter	NOUN
dti-1301	316	2	,	,	PUNCT
dti-1301	316	3	j.	j.	PROPN
dti-1301	316	4	and	and	CCONJ
dti-1301	316	5	hirst	hirst	PROPN
dti-1301	316	6	,	,	PUNCT
dti-1301	316	7	b.h	b.h	PROPN
dti-1301	316	8	.	.	PROPN
dti-1301	316	9	1997	1997	NUM
dti-1301	316	10	.	.	PUNCT
dti-1301	317	1	intestinal	intestinal	ADJ
dti-1301	317	2	secretions	secretion	NOUN
dti-1301	317	3	of	of	ADP
dti-1301	317	4	drugs	drug	NOUN
dti-1301	317	5	:	:	PUNCT
dti-1301	317	6	the	the	DET
dti-1301	317	7	role	role	NOUN
dti-1301	317	8	of	of	ADP
dti-1301	317	9	p	p	NOUN
dti-1301	317	10	-	-	PUNCT
dti-1301	317	11	glycoprotein	glycoprotein	NOUN
dti-1301	317	12	and	and	CCONJ
dti-1301	317	13	related	relate	VERB
dti-1301	317	14	drug	drug	NOUN
dti-1301	317	15	effl	effl	PROPN
dti-1301	317	16	ux	ux	PROPN
dti-1301	317	17	systems	system	NOUN
dti-1301	317	18	in	in	ADP
dti-1301	317	19	limiting	limit	VERB
dti-1301	317	20	oral	oral	ADJ
dti-1301	317	21	drug	drug	NOUN
dti-1301	317	22	absorption	absorption	NOUN
dti-1301	317	23	.	.	PUNCT
dti-1301	318	1	adv	adv	PROPN
dti-1301	318	2	.	.	PUNCT
dti-1301	318	3	drug	drug	PROPN
dti-1301	318	4	deliv	deliv	PROPN
dti-1301	318	5	.	.	PUNCT
dti-1301	319	1	rev	rev	PROPN
dti-1301	319	2	.	.	PROPN
dti-1301	319	3	,	,	PUNCT
dti-1301	319	4	25:129–57	25:129–57	NUM
dti-1301	319	5	.	.	PUNCT
dti-1301	320	1	iacopetta	iacopetta	PROPN
dti-1301	320	2	,	,	PUNCT
dti-1301	320	3	b.j	b.j	PROPN
dti-1301	320	4	.	.	PROPN
dti-1301	320	5	,	,	PUNCT
dti-1301	320	6	morgan	morgan	PROPN
dti-1301	320	7	,	,	PUNCT
dti-1301	320	8	e.h	e.h	PROPN
dti-1301	320	9	.	.	PROPN
dti-1301	320	10	and	and	CCONJ
dti-1301	320	11	yeoh	yeoh	PROPN
dti-1301	320	12	,	,	PUNCT
dti-1301	320	13	gct	gct	PROPN
dti-1301	320	14	.	.	PROPN
dti-1301	320	15	1982	1982	NUM
dti-1301	320	16	.	.	PUNCT
dti-1301	321	1	transferrin	transferrin	NOUN
dti-1301	321	2	receptors	receptor	NOUN
dti-1301	321	3	and	and	CCONJ
dti-1301	321	4	iron	iron	NOUN
dti-1301	321	5	uptake	uptake	NOUN
dti-1301	321	6	during	during	ADP
dti-1301	321	7	erythroid	erythroid	PROPN
dti-1301	321	8	cell	cell	NOUN
dti-1301	321	9	development	development	NOUN
dti-1301	321	10	.	.	PUNCT
dti-1301	322	1	biochim	biochim	NOUN
dti-1301	322	2	.	.	PUNCT
dti-1301	323	1	biophys	biophy	NOUN
dti-1301	323	2	.	.	PUNCT
dti-1301	324	1	acta	acta	PROPN
dti-1301	324	2	.	.	PROPN
dti-1301	324	3	,	,	PUNCT
dti-1301	325	1	687:204–10	687:204–10	NOUN
dti-1301	325	2	.	.	PUNCT
dti-1301	326	1	jefferies	jefferies	PROPN
dti-1301	326	2	,	,	PUNCT
dti-1301	326	3	a.e	a.e	PROPN
dti-1301	326	4	.	.	PROPN
dti-1301	326	5	,	,	PUNCT
dti-1301	326	6	brandon	brandon	PROPN
dti-1301	326	7	,	,	PUNCT
dti-1301	326	8	m.r	m.r	PROPN
dti-1301	326	9	.	.	PROPN
dti-1301	326	10	and	and	CCONJ
dti-1301	326	11	hunt	hunt	PROPN
dti-1301	326	12	,	,	PUNCT
dti-1301	326	13	s.v	s.v	PROPN
dti-1301	326	14	.	.	PROPN
dti-1301	326	15	et	et	PROPN
dti-1301	326	16	al	al	PROPN
dti-1301	326	17	.	.	PROPN
dti-1301	326	18	1984	1984	NUM
dti-1301	326	19	.	.	PUNCT
dti-1301	327	1	transferrin	transferrin	NOUN
dti-1301	327	2	receptors	receptor	NOUN
dti-1301	327	3	on	on	ADP
dti-1301	327	4	endothelium	endothelium	NOUN
dti-1301	327	5	of	of	ADP
dti-1301	327	6	brain	brain	NOUN
dti-1301	327	7	capillaries	capillary	NOUN
dti-1301	327	8	.	.	PUNCT
dti-1301	328	1	nature	nature	NOUN
dti-1301	328	2	,	,	PUNCT
dti-1301	328	3	312:162–163	312:162–163	NUM
dti-1301	328	4	.	.	PUNCT
dti-1301	329	1	katragadda	katragadda	PROPN
dti-1301	329	2	,	,	PUNCT
dti-1301	329	3	s.	s.	PROPN
dti-1301	329	4	,	,	PUNCT
dti-1301	329	5	budda	budda	PROPN
dti-1301	329	6	,	,	PUNCT
dti-1301	329	7	b.	b.	PROPN
dti-1301	329	8	and	and	CCONJ
dti-1301	329	9	anand	anand	PROPN
dti-1301	329	10	,	,	PUNCT
dti-1301	329	11	a.	a.	PROPN
dti-1301	329	12	et	et	PROPN
dti-1301	329	13	al	al	PROPN
dti-1301	329	14	.	.	PROPN
dti-1301	329	15	2005	2005	NUM
dti-1301	329	16	.	.	PUNCT
dti-1301	330	1	role	role	NOUN
dti-1301	330	2	of	of	ADP
dti-1301	330	3	effl	effl	PROPN
dti-1301	330	4	ux	ux	PROPN
dti-1301	330	5	pumps	pump	NOUN
dti-1301	330	6	and	and	CCONJ
dti-1301	330	7	metabolising	metabolise	VERB
dti-1301	330	8	enzymes	enzyme	NOUN
dti-1301	330	9	in	in	ADP
dti-1301	330	10	drug	drug	NOUN
dti-1301	330	11	delivery	delivery	NOUN
dti-1301	330	12	.	.	PUNCT
dti-1301	331	1	expert	expert	NOUN
dti-1301	331	2	.	.	PUNCT
dti-1301	332	1	opin	opin	NOUN
dti-1301	332	2	.	.	PUNCT
dti-1301	333	1	drug	drug	NOUN
dti-1301	333	2	deliv	deliv	NOUN
dti-1301	333	3	.	.	PUNCT
dti-1301	333	4	,	,	PUNCT
dti-1301	333	5	2(4):683–705	2(4):683–705	NUM
dti-1301	333	6	.	.	PUNCT
dti-1301	334	1	kilpatrick	kilpatrick	PROPN
dti-1301	334	2	,	,	PUNCT
dti-1301	334	3	d.c	d.c	PROPN
dti-1301	334	4	.	.	PROPN
dti-1301	334	5	,	,	PUNCT
dti-1301	334	6	pusztai	pusztai	NOUN
dti-1301	334	7	,	,	PUNCT
dti-1301	334	8	a.	a.	NOUN
dti-1301	334	9	and	and	CCONJ
dti-1301	334	10	grant	grant	PROPN
dti-1301	334	11	,	,	PUNCT
dti-1301	334	12	g.	g.	PROPN
dti-1301	334	13	et	et	PROPN
dti-1301	334	14	al	al	PROPN
dti-1301	334	15	.	.	PROPN
dti-1301	334	16	1985	1985	NUM
dti-1301	334	17	.	.	PUNCT
dti-1301	335	1	tomato	tomato	NOUN
dti-1301	335	2	lectin	lectin	NOUN
dti-1301	335	3	resists	resist	VERB
dti-1301	335	4	digestion	digestion	NOUN
dti-1301	335	5	in	in	ADP
dti-1301	335	6	mammalian	mammalian	ADJ
dti-1301	335	7	alimentary	alimentary	ADJ
dti-1301	335	8	canal	canal	NOUN
dti-1301	335	9	and	and	CCONJ
dti-1301	335	10	binds	bind	VERB
dti-1301	335	11	to	to	ADP
dti-1301	335	12	intestinal	intestinal	ADJ
dti-1301	335	13	villi	villi	NOUN
dti-1301	335	14	without	without	ADP
dti-1301	335	15	deleterious	deleterious	ADJ
dti-1301	335	16	effects	effect	NOUN
dti-1301	335	17	.	.	PUNCT
dti-1301	336	1	febs	febs	PROPN
dti-1301	336	2	lett	lett	PROPN
dti-1301	336	3	.	.	PROPN
dti-1301	336	4	,	,	PUNCT
dti-1301	336	5	185:299–305	185:299–305	NUM
dti-1301	336	6	.	.	PUNCT
dti-1301	337	1	king	king	PROPN
dti-1301	337	2	,	,	PUNCT
dti-1301	337	3	t.p	t.p	PROPN
dti-1301	337	4	.	.	PROPN
dti-1301	337	5	,	,	PUNCT
dti-1301	337	6	pusztai	pusztai	NOUN
dti-1301	337	7	,	,	PUNCT
dti-1301	337	8	a.	a.	NOUN
dti-1301	337	9	and	and	CCONJ
dti-1301	337	10	grant	grant	PROPN
dti-1301	337	11	,	,	PUNCT
dti-1301	337	12	g.	g.	PROPN
dti-1301	337	13	et	et	PROPN
dti-1301	337	14	al	al	PROPN
dti-1301	337	15	.	.	PROPN
dti-1301	337	16	1986	1986	NUM
dti-1301	337	17	.	.	PUNCT
dti-1301	338	1	immunogold	immunogold	ADJ
dti-1301	338	2	localization	localization	NOUN
dti-1301	338	3	of	of	ADP
dti-1301	338	4	ingested	ingest	VERB
dti-1301	338	5	kidney	kidney	NOUN
dti-1301	338	6	bean	bean	NOUN
dti-1301	338	7	(	(	PUNCT
dti-1301	338	8	phaseolus	phaseolus	ADJ
dti-1301	338	9	vulgaries	vulgarie	NOUN
dti-1301	338	10	)	)	PUNCT
dti-1301	338	11	lectin	lectin	NOUN
dti-1301	338	12	in	in	ADP
dti-1301	338	13	epithelial	epithelial	ADJ
dti-1301	338	14	cells	cell	NOUN
dti-1301	338	15	of	of	ADP
dti-1301	338	16	the	the	DET
dti-1301	338	17	rat	rat	NOUN
dti-1301	338	18	small	small	ADJ
dti-1301	338	19	intestine	intestine	NOUN
dti-1301	338	20	.	.	PUNCT
dti-1301	339	1	histochem	histochem	PROPN
dti-1301	339	2	.	.	PUNCT
dti-1301	340	1	j.	j.	PROPN
dti-1301	340	2	,	,	PUNCT
dti-1301	340	3	18:413–20	18:413–20	PROPN
dti-1301	340	4	.	.	PUNCT
dti-1301	340	5	kovar	kovar	PROPN
dti-1301	340	6	,	,	PUNCT
dti-1301	340	7	m.	m.	NOUN
dti-1301	340	8	,	,	PUNCT
dti-1301	340	9	strohalm	strohalm	PROPN
dti-1301	340	10	,	,	PUNCT
dti-1301	340	11	j.	j.	PROPN
dti-1301	340	12	and	and	CCONJ
dti-1301	340	13	ulbrich	ulbrich	PROPN
dti-1301	340	14	,	,	PUNCT
dti-1301	340	15	k.	k.	PROPN
dti-1301	340	16	et	et	PROPN
dti-1301	340	17	al	al	PROPN
dti-1301	340	18	.	.	PROPN
dti-1301	340	19	2002	2002	NUM
dti-1301	340	20	.	.	PUNCT
dti-1301	341	1	in	in	ADP
dti-1301	341	2	vitro	vitro	X
dti-1301	341	3	and	and	CCONJ
dti-1301	341	4	in	in	ADP
dti-1301	341	5	vivo	vivo	ADJ
dti-1301	341	6	effect	effect	NOUN
dti-1301	341	7	of	of	ADP
dti-1301	341	8	hpma	hpma	NOUN
dti-1301	341	9	copolymer	copolymer	NOUN
dti-1301	341	10	-	-	PUNCT
dti-1301	341	11	bound	bind	VERB
dti-1301	341	12	doxorubicin	doxorubicin	PROPN
dti-1301	341	13	targeted	target	VERB
dti-1301	341	14	transferrin	transferrin	ADJ
dti-1301	341	15	receptor	receptor	NOUN
dti-1301	341	16	to	to	ADP
dti-1301	341	17	b	b	NOUN
dti-1301	341	18	-	-	PUNCT
dti-1301	341	19	cell	cell	NOUN
dti-1301	341	20	lymphoma	lymphoma	NOUN
dti-1301	341	21	38c13	38c13	NUM
dti-1301	341	22	.	.	PUNCT
dti-1301	342	1	drug	drug	NOUN
dti-1301	342	2	target	target	NOUN
dti-1301	342	3	,	,	PUNCT
dti-1301	342	4	10:23–30	10:23–30	NUM
dti-1301	342	5	.	.	PUNCT
dti-1301	343	1	kursa	kursa	PROPN
dti-1301	343	2	,	,	PUNCT
dti-1301	343	3	m.	m.	NOUN
dti-1301	343	4	,	,	PUNCT
dti-1301	343	5	walker	walker	PROPN
dti-1301	343	6	,	,	PUNCT
dti-1301	343	7	g.f	g.f	PROPN
dti-1301	343	8	.	.	PROPN
dti-1301	343	9	,	,	PUNCT
dti-1301	343	10	roessler	roessler	NOUN
dti-1301	343	11	,	,	PUNCT
dti-1301	343	12	v.	v.	ADP
dti-1301	343	13	and	and	CCONJ
dti-1301	343	14	ogris	ogris	PROPN
dti-1301	343	15	,	,	PUNCT
dti-1301	343	16	m.	m.	NOUN
dti-1301	343	17	et	et	PROPN
dti-1301	343	18	al	al	PROPN
dti-1301	343	19	.	.	PROPN
dti-1301	343	20	2003	2003	NUM
dti-1301	343	21	.	.	PUNCT
dti-1301	344	1	novel	novel	NOUN
dti-1301	344	2	shielded	shield	VERB
dti-1301	344	3	transferring	transferring	NOUN
dti-1301	344	4	-	-	PUNCT
dti-1301	344	5	polyethylene	polyethylene	NOUN
dti-1301	344	6	glycol	glycol	NOUN
dti-1301	344	7	-	-	PUNCT
dti-1301	344	8	polyethylenimine	polyethylenimine	NOUN
dti-1301	344	9	/	/	SYM
dti-1301	344	10	dna	dna	NOUN
dti-1301	344	11	complexes	complex	NOUN
dti-1301	344	12	for	for	ADP
dti-1301	344	13	systemic	systemic	ADJ
dti-1301	344	14	tumor	tumor	NOUN
dti-1301	344	15	-	-	PUNCT
dti-1301	344	16	targeted	target	VERB
dti-1301	344	17	gene	gene	NOUN
dti-1301	344	18	transfer	transfer	NOUN
dti-1301	344	19	.	.	PUNCT
dti-1301	345	1	bioconj.chem	bioconj.chem	PRON
dti-1301	345	2	.	.	PROPN
dti-1301	345	3	,	,	PUNCT
dti-1301	345	4	14:222–31	14:222–31	NUM
dti-1301	345	5	.	.	PUNCT
dti-1301	346	1	lacombe	lacombe	PROPN
dti-1301	346	2	,	,	PUNCT
dti-1301	346	3	o.	o.	PROPN
dti-1301	346	4	,	,	PUNCT
dti-1301	346	5	woodley	woodley	NOUN
dti-1301	346	6	,	,	PUNCT
dti-1301	346	7	j.	j.	PROPN
dti-1301	346	8	,	,	PUNCT
dti-1301	346	9	solleux	solleux	PROPN
dti-1301	346	10	,	,	PUNCT
dti-1301	346	11	c.	c.	NOUN
dti-1301	346	12	and	and	CCONJ
dti-1301	346	13	delbos	delbo	NOUN
dti-1301	346	14	,	,	PUNCT
dti-1301	346	15	j	j	NOUN
dti-1301	346	16	-	-	PUNCT
dti-1301	346	17	m.	m.	NOUN
dti-1301	346	18	et	et	PROPN
dti-1301	346	19	al	al	PROPN
dti-1301	346	20	.	.	PROPN
dti-1301	346	21	2004	2004	NUM
dti-1301	346	22	.	.	PUNCT
dti-1301	347	1	localization	localization	NOUN
dti-1301	347	2	of	of	ADP
dti-1301	347	3	drug	drug	NOUN
dti-1301	347	4	permeability	permeability	NOUN
dti-1301	347	5	along	along	ADP
dti-1301	347	6	the	the	DET
dti-1301	347	7	rat	rat	NOUN
dti-1301	347	8	small	small	ADJ
dti-1301	347	9	intestine	intestine	NOUN
dti-1301	347	10	,	,	PUNCT
dti-1301	347	11	using	use	VERB
dti-1301	347	12	markers	marker	NOUN
dti-1301	347	13	of	of	ADP
dti-1301	347	14	the	the	DET
dti-1301	347	15	paracellular	paracellular	ADJ
dti-1301	347	16	,	,	PUNCT
dti-1301	347	17	transcellular	transcellular	NOUN
dti-1301	347	18	and	and	CCONJ
dti-1301	347	19	some	some	DET
dti-1301	347	20	transporter	transporter	NOUN
dti-1301	347	21	routes	route	NOUN
dti-1301	347	22	.	.	PUNCT
dti-1301	348	1	eur	eur	PROPN
dti-1301	348	2	.	.	PUNCT
dti-1301	349	1	j.	j.	PROPN
dti-1301	349	2	pharm	pharm	PROPN
dti-1301	349	3	.	.	PUNCT
dti-1301	350	1	sci	sci	PROPN
dti-1301	350	2	.	.	PROPN
dti-1301	350	3	,	,	PUNCT
dti-1301	350	4	23:385–91	23:385–91	NUM
dti-1301	350	5	.	.	PUNCT
dti-1301	351	1	lee	lee	PROPN
dti-1301	351	2	,	,	PUNCT
dti-1301	351	3	vhl	vhl	PROPN
dti-1301	351	4	.	.	PUNCT
dti-1301	351	5	2000	2000	NUM
dti-1301	351	6	.	.	PUNCT
dti-1301	352	1	membrane	membrane	NOUN
dti-1301	352	2	transporters	transporter	NOUN
dti-1301	352	3	.	.	PUNCT
dti-1301	353	1	eur	eur	PROPN
dti-1301	353	2	.	.	PUNCT
dti-1301	354	1	j.	j.	PROPN
dti-1301	354	2	pharm	pharm	PROPN
dti-1301	354	3	.	.	PUNCT
dti-1301	355	1	sci	sci	PROPN
dti-1301	355	2	.	.	PROPN
dti-1301	355	3	,	,	PUNCT
dti-1301	355	4	11	11	NUM
dti-1301	355	5	:	:	PUNCT
dti-1301	355	6	s41–50	s41–50	NOUN
dti-1301	355	7	.	.	PUNCT
dti-1301	356	1	lehr	lehr	NOUN
dti-1301	356	2	,	,	PUNCT
dti-1301	356	3	c.m	c.m	PROPN
dti-1301	356	4	.	.	PROPN
dti-1301	356	5	,	,	PUNCT
dti-1301	356	6	bouwstra	bouwstra	PROPN
dti-1301	356	7	,	,	PUNCT
dti-1301	356	8	j.a	j.a	PROPN
dti-1301	356	9	.	.	PROPN
dti-1301	356	10	and	and	CCONJ
dti-1301	356	11	kok	kok	PROPN
dti-1301	356	12	,	,	PUNCT
dti-1301	356	13	w.	w.	PROPN
dti-1301	356	14	et	et	PROPN
dti-1301	356	15	al	al	PROPN
dti-1301	356	16	.	.	PROPN
dti-1301	356	17	1992	1992	NUM
dti-1301	356	18	.	.	PUNCT
dti-1301	357	1	bioadhesion	bioadhesion	NOUN
dti-1301	357	2	by	by	ADP
dti-1301	357	3	means	mean	NOUN
dti-1301	357	4	of	of	ADP
dti-1301	357	5	specifi	specifi	PROPN
dti-1301	357	6	c	c	PROPN
dti-1301	357	7	binding	bind	VERB
dti-1301	357	8	of	of	ADP
dti-1301	357	9	tomato	tomato	NOUN
dti-1301	357	10	lectin	lectin	NOUN
dti-1301	357	11	.	.	PUNCT
dti-1301	358	1	pharmacol	pharmacol	PROPN
dti-1301	358	2	.	.	PUNCT
dti-1301	359	1	res	re	NOUN
dti-1301	359	2	.	.	PROPN
dti-1301	359	3	,	,	PUNCT
dti-1301	360	1	9:547–53	9:547–53	PROPN
dti-1301	360	2	.	.	PUNCT
dti-1301	360	3	lennernäs	lennernäs	PROPN
dti-1301	360	4	,	,	PUNCT
dti-1301	360	5	h.	h.	PROPN
dti-1301	360	6	1998	1998	NUM
dti-1301	360	7	.	.	PUNCT
dti-1301	361	1	human	human	ADJ
dti-1301	361	2	intestinal	intestinal	ADJ
dti-1301	361	3	permeability	permeability	NOUN
dti-1301	361	4	.	.	PUNCT
dti-1301	362	1	j.	j.	PROPN
dti-1301	362	2	pharm	pharm	PROPN
dti-1301	362	3	.	.	PUNCT
dti-1301	363	1	sci	sci	PROPN
dti-1301	363	2	.	.	PROPN
dti-1301	363	3	,	,	PUNCT
dti-1301	363	4	87(4	87(4	NUM
dti-1301	363	5	):	):	PUNCT
dti-1301	363	6	403–10	403–10	NUM
dti-1301	363	7	.	.	PUNCT
dti-1301	364	1	leonard	leonard	PROPN
dti-1301	364	2	,	,	PUNCT
dti-1301	364	3	t.w	t.w	PROPN
dti-1301	364	4	.	.	PROPN
dti-1301	364	5	,	,	PUNCT
dti-1301	364	6	lynch	lynch	PROPN
dti-1301	364	7	,	,	PUNCT
dti-1301	364	8	j.	j.	PROPN
dti-1301	364	9	and	and	CCONJ
dti-1301	364	10	mckenna	mckenna	PROPN
dti-1301	364	11	,	,	PUNCT
dti-1301	364	12	m.j	m.j	PROPN
dti-1301	364	13	.	.	PROPN
dti-1301	364	14	et	et	PROPN
dti-1301	364	15	al	al	PROPN
dti-1301	364	16	.	.	PROPN
dti-1301	364	17	2006	2006	NUM
dti-1301	364	18	.	.	PUNCT
dti-1301	365	1	promoting	promote	VERB
dti-1301	365	2	absorption	absorption	NOUN
dti-1301	365	3	of	of	ADP
dti-1301	365	4	drugs	drug	NOUN
dti-1301	365	5	in	in	ADP
dti-1301	365	6	humans	human	NOUN
dti-1301	365	7	medium	medium	ADJ
dti-1301	365	8	chain	chain	NOUN
dti-1301	365	9	fatty	fatty	NOUN
dti-1301	365	10	acid	acid	NOUN
dti-1301	365	11	-	-	PUNCT
dti-1301	365	12	based	base	VERB
dti-1301	365	13	solid	solid	ADJ
dti-1301	365	14	dosage	dosage	NOUN
dti-1301	365	15	forms	form	NOUN
dti-1301	365	16	:	:	PUNCT
dti-1301	365	17	gipet	gipet	NOUN
dti-1301	365	18	™	™	PROPN
dti-1301	365	19	.	.	PUNCT
dti-1301	366	1	expert	expert	NOUN
dti-1301	366	2	.	.	PUNCT
dti-1301	367	1	opin	opin	NOUN
dti-1301	367	2	.	.	PUNCT
dti-1301	367	3	drug	drug	NOUN
dti-1301	367	4	.	.	PUNCT
dti-1301	368	1	deliv	deliv	PROPN
dti-1301	368	2	.	.	PUNCT
dti-1301	368	3	,	,	PUNCT
dti-1301	368	4	3(5):685–92	3(5):685–92	PROPN
dti-1301	368	5	.	.	PUNCT
dti-1301	369	1	lindner	lindner	PROPN
dti-1301	369	2	,	,	PUNCT
dti-1301	369	3	j.	j.	PROPN
dti-1301	369	4	,	,	PUNCT
dti-1301	369	5	geczy	geczy	PROPN
dti-1301	369	6	,	,	PUNCT
dti-1301	369	7	a.f	a.f	PROPN
dti-1301	369	8	.	.	PROPN
dti-1301	369	9	and	and	CCONJ
dti-1301	369	10	russel	russel	PROPN
dti-1301	369	11	-	-	PUNCT
dti-1301	369	12	jones	jones	PROPN
dti-1301	369	13	,	,	PUNCT
dti-1301	369	14	g.j	g.j	PROPN
dti-1301	369	15	.	.	PROPN
dti-1301	369	16	1994	1994	NUM
dti-1301	369	17	.	.	PUNCT
dti-1301	370	1	identifi	identifi	PROPN
dti-1301	370	2	cation	cation	NOUN
dti-1301	370	3	of	of	ADP
dti-1301	370	4	the	the	DET
dti-1301	370	5	site	site	NOUN
dti-1301	370	6	of	of	ADP
dti-1301	370	7	uptake	uptake	NOUN
dti-1301	370	8	of	of	ADP
dti-1301	370	9	the	the	DET
dti-1301	370	10	e	e	NOUN
dti-1301	370	11	-	-	ADJ
dti-1301	370	12	coli	coli	ADJ
dti-1301	370	13	heat	heat	NOUN
dti-1301	370	14	labile	labile	ADJ
dti-1301	370	15	enterotoxin	enterotoxin	PROPN
dti-1301	370	16	,	,	PUNCT
dti-1301	370	17	ltb	ltb	PROPN
dti-1301	370	18	.	.	PUNCT
dti-1301	370	19	scand	scand	PROPN
dti-1301	370	20	.	.	PUNCT
dti-1301	371	1	j.	j.	PROPN
dti-1301	371	2	immunol	immunol	PROPN
dti-1301	371	3	.	.	PROPN
dti-1301	371	4	,	,	PUNCT
dti-1301	371	5	40:564–72	40:564–72	PROPN
dti-1301	371	6	.	.	PUNCT
dti-1301	372	1	lu	lu	PROPN
dti-1301	372	2	y.	y.	PROPN
dti-1301	372	3	and	and	CCONJ
dti-1301	372	4	low	low	ADJ
dti-1301	372	5	,	,	PUNCT
dti-1301	372	6	p.s	p.s	PROPN
dti-1301	372	7	.	.	PROPN
dti-1301	372	8	2002	2002	NUM
dti-1301	372	9	.	.	PUNCT
dti-1301	373	1	folate	folate	NOUN
dti-1301	373	2	-	-	PUNCT
dti-1301	373	3	mediated	mediate	VERB
dti-1301	373	4	delivery	delivery	NOUN
dti-1301	373	5	of	of	ADP
dti-1301	373	6	macromolecular	macromolecular	ADJ
dti-1301	373	7	anticancer	anticancer	NOUN
dti-1301	373	8	therapeutic	therapeutic	ADJ
dti-1301	373	9	agents	agent	NOUN
dti-1301	373	10	.	.	PUNCT
dti-1301	374	1	adv	adv	PROPN
dti-1301	374	2	.	.	PUNCT
dti-1301	374	3	drug	drug	PROPN
dti-1301	374	4	deliv	deliv	PROPN
dti-1301	374	5	.	.	PUNCT
dti-1301	375	1	rev	rev	PROPN
dti-1301	375	2	.	.	PROPN
dti-1301	375	3	,	,	PUNCT
dti-1301	375	4	54:675–93	54:675–93	PROPN
dti-1301	375	5	lund	lund	PROPN
dti-1301	375	6	,	,	PUNCT
dti-1301	375	7	w.	w.	PROPN
dti-1301	375	8	,	,	PUNCT
dti-1301	375	9	ed	ed	NOUN
dti-1301	375	10	.	.	PROPN
dti-1301	375	11	1994	1994	NUM
dti-1301	375	12	.	.	PUNCT
dti-1301	376	1	the	the	DET
dti-1301	376	2	pharmaceutical	pharmaceutical	ADJ
dti-1301	376	3	codex	codex	NOUN
dti-1301	376	4	.	.	PUNCT
dti-1301	377	1	london	london	PROPN
dti-1301	377	2	:	:	PUNCT
dti-1301	377	3	the	the	DET
dti-1301	377	4	pharmaceutical	pharmaceutical	NOUN
dti-1301	377	5	press	press	NOUN
dti-1301	377	6	.	.	PUNCT
dti-1301	378	1	majumdar	majumdar	PROPN
dti-1301	378	2	,	,	PUNCT
dti-1301	378	3	s.	s.	PROPN
dti-1301	378	4	,	,	PUNCT
dti-1301	378	5	duvuri	duvuri	PROPN
dti-1301	378	6	,	,	PUNCT
dti-1301	378	7	s.	s.	PROPN
dti-1301	378	8	and	and	CCONJ
dti-1301	378	9	mitra	mitra	PROPN
dti-1301	378	10	,	,	PUNCT
dti-1301	378	11	a.k	a.k	PROPN
dti-1301	378	12	.	.	PROPN
dti-1301	378	13	2004	2004	NUM
dti-1301	378	14	.	.	PUNCT
dti-1301	379	1	membrane	membrane	NOUN
dti-1301	379	2	transporter/	transporter/	NUM
dti-1301	379	3	receptor	receptor	NOUN
dti-1301	379	4	-	-	PUNCT
dti-1301	379	5	targeted	target	VERB
dti-1301	379	6	prodrug	prodrug	NOUN
dti-1301	379	7	design	design	NOUN
dti-1301	379	8	:	:	PUNCT
dti-1301	379	9	strategies	strategy	NOUN
dti-1301	379	10	for	for	ADP
dti-1301	379	11	human	human	ADJ
dti-1301	379	12	and	and	CCONJ
dti-1301	379	13	veterinary	veterinary	ADJ
dti-1301	379	14	drug	drug	NOUN
dti-1301	379	15	development	development	NOUN
dti-1301	379	16	.	.	PUNCT
dti-1301	380	1	adv	adv	PROPN
dti-1301	380	2	.	.	PUNCT
dti-1301	380	3	drug	drug	PROPN
dti-1301	380	4	deliv	deliv	PROPN
dti-1301	380	5	.	.	PUNCT
dti-1301	381	1	rev	rev	PROPN
dti-1301	381	2	.	.	PROPN
dti-1301	381	3	,	,	PUNCT
dti-1301	381	4	56:1437–52	56:1437–52	NUM
dti-1301	381	5	.	.	PUNCT
dti-1301	382	1	majumdar	majumdar	PROPN
dti-1301	382	2	,	,	PUNCT
dti-1301	382	3	s.	s.	PROPN
dti-1301	382	4	and	and	CCONJ
dti-1301	382	5	mitra	mitra	PROPN
dti-1301	382	6	,	,	PUNCT
dti-1301	382	7	a.	a.	PROPN
dti-1301	382	8	2006	2006	NUM
dti-1301	382	9	.	.	PUNCT
dti-1301	383	1	chemical	chemical	PROPN
dti-1301	383	2	modifi	modifi	PROPN
dti-1301	383	3	cation	cation	NOUN
dti-1301	383	4	and	and	CCONJ
dti-1301	383	5	formulation	formulation	NOUN
dti-1301	383	6	approaches	approach	NOUN
dti-1301	383	7	to	to	ADP
dti-1301	383	8	elevated	elevated	ADJ
dti-1301	383	9	drug	drug	NOUN
dti-1301	383	10	transport	transport	NOUN
dti-1301	383	11	across	across	ADP
dti-1301	383	12	cell	cell	NOUN
dti-1301	383	13	membranes	membrane	NOUN
dti-1301	383	14	.	.	PUNCT
dti-1301	384	1	expert	expert	NOUN
dti-1301	384	2	opin	opin	NOUN
dti-1301	384	3	.	.	PUNCT
dti-1301	385	1	drug	drug	NOUN
dti-1301	385	2	deliv	deliv	NOUN
dti-1301	385	3	.	.	PUNCT
dti-1301	385	4	,	,	PUNCT
dti-1301	386	1	3(4):511–27	3(4):511–27	PROPN
dti-1301	386	2	.	.	PUNCT
dti-1301	387	1	masaoka	masaoka	PROPN
dti-1301	387	2	,	,	PUNCT
dti-1301	387	3	y.	y.	PROPN
dti-1301	387	4	,	,	PUNCT
dti-1301	387	5	tanaka	tanaka	PROPN
dti-1301	387	6	,	,	PUNCT
dti-1301	387	7	y.	y.	PROPN
dti-1301	387	8	and	and	CCONJ
dti-1301	387	9	kataoke	kataoke	PROPN
dti-1301	387	10	,	,	PUNCT
dti-1301	387	11	m.	m.	NOUN
dti-1301	387	12	et	et	PROPN
dti-1301	387	13	al	al	PROPN
dti-1301	387	14	.	.	PROPN
dti-1301	387	15	2006	2006	NUM
dti-1301	387	16	.	.	PUNCT
dti-1301	388	1	site	site	NOUN
dti-1301	388	2	of	of	ADP
dti-1301	388	3	absorption	absorption	NOUN
dti-1301	388	4	after	after	ADP
dti-1301	388	5	oral	oral	ADJ
dti-1301	388	6	administration	administration	NOUN
dti-1301	388	7	:	:	PUNCT
dti-1301	388	8	assessment	assessment	NOUN
dti-1301	388	9	of	of	ADP
dti-1301	388	10	membrane	membrane	NOUN
dti-1301	388	11	permeability	permeability	NOUN
dti-1301	388	12	and	and	CCONJ
dti-1301	388	13	luminal	luminal	ADJ
dti-1301	388	14	concentration	concentration	NOUN
dti-1301	388	15	of	of	ADP
dti-1301	388	16	drugs	drug	NOUN
dti-1301	388	17	in	in	ADP
dti-1301	388	18	each	each	DET
dti-1301	388	19	segment	segment	NOUN
dti-1301	388	20	of	of	ADP
dti-1301	388	21	gastrointestinal	gastrointestinal	ADJ
dti-1301	388	22	tract	tract	NOUN
dti-1301	388	23	.	.	PUNCT
dti-1301	389	1	eur	eur	PROPN
dti-1301	389	2	.	.	PUNCT
dti-1301	390	1	j.	j.	PROPN
dti-1301	390	2	pharm	pharm	PROPN
dti-1301	390	3	.	.	PUNCT
dti-1301	391	1	sci	sci	PROPN
dti-1301	391	2	.	.	PROPN
dti-1301	391	3	,	,	PUNCT
dti-1301	391	4	in	in	ADP
dti-1301	391	5	press	press	NOUN
dti-1301	391	6	.	.	PUNCT
dti-1301	392	1	morishita	morishita	PROPN
dti-1301	392	2	,	,	PUNCT
dti-1301	392	3	m.	m.	NOUN
dti-1301	392	4	and	and	CCONJ
dti-1301	392	5	peppas	peppa	NOUN
dti-1301	392	6	,	,	PUNCT
dti-1301	392	7	n.a	n.a	PROPN
dti-1301	392	8	.	.	PROPN
dti-1301	392	9	2006	2006	NUM
dti-1301	392	10	.	.	PUNCT
dti-1301	392	11	is	be	AUX
dti-1301	392	12	the	the	DET
dti-1301	392	13	oral	oral	ADJ
dti-1301	392	14	route	route	NOUN
dti-1301	392	15	possible	possible	ADJ
dti-1301	392	16	for	for	ADP
dti-1301	392	17	peptide	peptide	NOUN
dti-1301	392	18	and	and	CCONJ
dti-1301	392	19	protein	protein	NOUN
dti-1301	392	20	drug	drug	NOUN
dti-1301	392	21	delivery	delivery	NOUN
dti-1301	392	22	?	?	PUNCT
dti-1301	393	1	drug	drug	NOUN
dti-1301	393	2	discov	discov	NOUN
dti-1301	393	3	.	.	PUNCT
dti-1301	394	1	today	today	NOUN
dti-1301	394	2	.	.	PUNCT
dti-1301	395	1	,	,	PUNCT
dti-1301	395	2	11:905–10	11:905–10	PROPN
dti-1301	395	3	.	.	PUNCT
dti-1301	396	1	morris	morris	PROPN
dti-1301	396	2	,	,	PUNCT
dti-1301	396	3	s.a	s.a	PROPN
dti-1301	396	4	.	.	PROPN
dti-1301	396	5	,	,	PUNCT
dti-1301	396	6	ahle	ahle	PROPN
dti-1301	396	7	,	,	PUNCT
dti-1301	396	8	s.	s.	PROPN
dti-1301	396	9	and	and	CCONJ
dti-1301	396	10	ungewickell	ungewickell	PROPN
dti-1301	396	11	,	,	PUNCT
dti-1301	396	12	e.	e.	PROPN
dti-1301	396	13	1989	1989	NUM
dti-1301	396	14	.	.	PUNCT
dti-1301	397	1	clathrin	clathrin	NOUN
dti-1301	397	2	-	-	PUNCT
dti-1301	397	3	coated	coat	VERB
dti-1301	397	4	vesicles	vesicle	NOUN
dti-1301	397	5	.	.	PUNCT
dti-1301	398	1	curr	curr	PROPN
dti-1301	398	2	.	.	PUNCT
dti-1301	399	1	opin	opin	NOUN
dti-1301	399	2	.	.	PUNCT
dti-1301	400	1	cell	cell	NOUN
dti-1301	400	2	.	.	PUNCT
dti-1301	401	1	biol	biol	PROPN
dti-1301	401	2	.	.	PUNCT
dti-1301	401	3	,	,	PUNCT
dti-1301	401	4	1:684–90	1:684–90	X
dti-1301	401	5	.	.	PUNCT
dti-1301	402	1	mostov	mostov	PROPN
dti-1301	402	2	,	,	PUNCT
dti-1301	402	3	k.e	k.e	PROPN
dti-1301	402	4	.	.	PROPN
dti-1301	402	5	and	and	CCONJ
dti-1301	402	6	simister	simister	PROPN
dti-1301	402	7	,	,	PUNCT
dti-1301	402	8	n.e	n.e	PROPN
dti-1301	402	9	.	.	PROPN
dti-1301	402	10	1985	1985	NUM
dti-1301	402	11	.	.	PUNCT
dti-1301	403	1	transcytosis	transcytosis	NOUN
dti-1301	403	2	.	.	PUNCT
dti-1301	404	1	cell	cell	NOUN
dti-1301	404	2	.	.	PUNCT
dti-1301	404	3	,	,	PUNCT
dti-1301	405	1	43:389–90	43:389–90	PROPN
dti-1301	405	2	.	.	PUNCT
dti-1301	406	1	ni	ni	PROPN
dti-1301	406	2	,	,	PUNCT
dti-1301	406	3	s.	s.	PROPN
dti-1301	406	4	,	,	PUNCT
dti-1301	406	5	stephenson	stephenson	PROPN
dti-1301	406	6	,	,	PUNCT
dti-1301	406	7	s.m	s.m	PROPN
dti-1301	406	8	.	.	PROPN
dti-1301	406	9	and	and	CCONJ
dti-1301	406	10	r.j	r.j	PROPN
dti-1301	406	11	.	.	PROPN
dti-1301	406	12	2002	2002	NUM
dti-1301	406	13	.	.	PUNCT
dti-1301	407	1	folate	folate	NOUN
dti-1301	407	2	receptor	receptor	NOUN
dti-1301	407	3	targeted	target	VERB
dti-1301	407	4	delivery	delivery	NOUN
dti-1301	407	5	of	of	ADP
dti-1301	407	6	liposomal	liposomal	ADJ
dti-1301	407	7	daunorubicin	daunorubicin	PROPN
dti-1301	407	8	into	into	ADP
dti-1301	407	9	tumor	tumor	NOUN
dti-1301	407	10	cells	cell	NOUN
dti-1301	407	11	.	.	PUNCT
dti-1301	408	1	anticancer	anticancer	NOUN
dti-1301	408	2	res	re	NOUN
dti-1301	408	3	.	.	PROPN
dti-1301	408	4	,	,	PUNCT
dti-1301	408	5	22:2131–2135	22:2131–2135	X
dti-1301	408	6	.	.	X
dti-1301	408	7	pauletti	pauletti	PROPN
dti-1301	408	8	,	,	PUNCT
dti-1301	408	9	g.m	g.m	PROPN
dti-1301	408	10	.	.	PROPN
dti-1301	408	11	,	,	PUNCT
dti-1301	408	12	gangwar	gangwar	PROPN
dti-1301	408	13	,	,	PUNCT
dti-1301	408	14	s.	s.	PROPN
dti-1301	408	15	and	and	CCONJ
dti-1301	408	16	knipp	knipp	PROPN
dti-1301	408	17	,	,	PUNCT
dti-1301	408	18	g.t	g.t	PROPN
dti-1301	408	19	.	.	PROPN
dti-1301	408	20	et	et	PROPN
dti-1301	408	21	al	al	PROPN
dti-1301	408	22	.	.	PROPN
dti-1301	408	23	1996	1996	NUM
dti-1301	408	24	.	.	PUNCT
dti-1301	409	1	structural	structural	ADJ
dti-1301	409	2	requirements	requirement	NOUN
dti-1301	409	3	for	for	ADP
dti-1301	409	4	intestinal	intestinal	ADJ
dti-1301	409	5	absorption	absorption	NOUN
dti-1301	409	6	of	of	ADP
dti-1301	409	7	peptide	peptide	ADJ
dti-1301	409	8	drugs	drug	NOUN
dti-1301	409	9	.	.	PUNCT
dti-1301	410	1	j.	j.	PROPN
dti-1301	410	2	control	control	PROPN
dti-1301	410	3	release	release	PROPN
dti-1301	410	4	,	,	PUNCT
dti-1301	410	5	41:3–17	41:3–17	NUM
dti-1301	410	6	.	.	PUNCT
dti-1301	411	1	pusztai	pusztai	PROPN
dti-1301	411	2	,	,	PUNCT
dti-1301	411	3	a.	a.	NOUN
dti-1301	411	4	1989	1989	NUM
dti-1301	411	5	.	.	PUNCT
dti-1301	412	1	transport	transport	NOUN
dti-1301	412	2	of	of	ADP
dti-1301	412	3	proteins	protein	NOUN
dti-1301	412	4	through	through	ADP
dti-1301	412	5	the	the	DET
dti-1301	412	6	membranes	membrane	NOUN
dti-1301	412	7	of	of	ADP
dti-1301	412	8	the	the	DET
dti-1301	412	9	adult	adult	NOUN
dti-1301	412	10	gastro	gastro	NOUN
dti-1301	412	11	-	-	PUNCT
dti-1301	412	12	intestinal	intestinal	ADJ
dti-1301	412	13	tract	tract	NOUN
dti-1301	412	14	—	—	PUNCT
dti-1301	412	15	a	a	DET
dti-1301	412	16	potential	potential	NOUN
dti-1301	412	17	for	for	ADP
dti-1301	412	18	drug	drug	NOUN
dti-1301	412	19	delivery	delivery	NOUN
dti-1301	412	20	?	?	PUNCT
dti-1301	413	1	adv	adv	PROPN
dti-1301	413	2	.	.	PUNCT
dti-1301	413	3	drug	drug	PROPN
dti-1301	413	4	deliv	deliv	PROPN
dti-1301	413	5	.	.	PUNCT
dti-1301	414	1	rev	rev	PROPN
dti-1301	414	2	.	.	PROPN
dti-1301	414	3	,	,	PUNCT
dti-1301	414	4	3:215–28	3:215–28	PROPN
dti-1301	414	5	.	.	PUNCT
dti-1301	415	1	qian	qian	PROPN
dti-1301	415	2	,	,	PUNCT
dti-1301	415	3	z.m	z.m	PROPN
dti-1301	415	4	.	.	PROPN
dti-1301	415	5	,	,	PUNCT
dti-1301	415	6	li	li	PROPN
dti-1301	415	7	,	,	PUNCT
dti-1301	415	8	h.	h.	PROPN
dti-1301	415	9	and	and	CCONJ
dti-1301	415	10	sun	sun	PROPN
dti-1301	415	11	,	,	PUNCT
dti-1301	415	12	h.	h.	PROPN
dti-1301	415	13	et	et	PROPN
dti-1301	415	14	al	al	PROPN
dti-1301	415	15	.	.	PROPN
dti-1301	415	16	2002	2002	NUM
dti-1301	415	17	.	.	PUNCT
dti-1301	416	1	targeted	target	VERB
dti-1301	416	2	drug	drug	NOUN
dti-1301	416	3	delivery	delivery	NOUN
dti-1301	416	4	via	via	ADP
dti-1301	416	5	transferring	transfer	VERB
dti-1301	416	6	receptor	receptor	NOUN
dti-1301	416	7	-	-	PUNCT
dti-1301	416	8	mediated	mediate	VERB
dti-1301	416	9	endocytosis	endocytosis	NOUN
dti-1301	416	10	pathway	pathway	NOUN
dti-1301	416	11	.	.	PUNCT
dti-1301	417	1	pharmacol	pharmacol	PROPN
dti-1301	417	2	.	.	PUNCT
dti-1301	418	1	rev	rev	PROPN
dti-1301	418	2	.	.	PROPN
dti-1301	418	3	,	,	PUNCT
dti-1301	418	4	54:561–587	54:561–587	NUM
dti-1301	418	5	.	.	PUNCT
dti-1301	419	1	raso	raso	NOUN
dti-1301	419	2	,	,	PUNCT
dti-1301	419	3	v.	v.	ADP
dti-1301	419	4	and	and	CCONJ
dti-1301	419	5	basala	basala	PROPN
dti-1301	419	6	,	,	PUNCT
dti-1301	419	7	m.	m.	NOUN
dti-1301	419	8	1984	1984	NUM
dti-1301	419	9	.	.	PUNCT
dti-1301	420	1	a	a	DET
dti-1301	420	2	highly	highly	ADV
dti-1301	420	3	cytotoxic	cytotoxic	ADJ
dti-1301	420	4	human	human	ADJ
dti-1301	420	5	transferrin	transferrin	NOUN
dti-1301	420	6	-	-	PUNCT
dti-1301	420	7	ricin	ricin	VERB
dti-1301	420	8	a	a	DET
dti-1301	420	9	chain	chain	NOUN
dti-1301	420	10	conjugate	conjugate	NOUN
dti-1301	420	11	used	use	VERB
dti-1301	420	12	to	to	PART
dti-1301	420	13	select	select	VERB
dti-1301	420	14	receptor	receptor	NOUN
dti-1301	420	15	-	-	PUNCT
dti-1301	420	16	modifi	modifi	NOUN
dti-1301	420	17	ed	ed	PROPN
dti-1301	420	18	cells	cell	NOUN
dti-1301	420	19	.	.	PUNCT
dti-1301	421	1	j.	j.	PROPN
dti-1301	421	2	biol	biol	PROPN
dti-1301	421	3	.	.	PUNCT
dti-1301	422	1	chem	chem	PROPN
dti-1301	422	2	.	.	PUNCT
dti-1301	422	3	,	,	PUNCT
dti-1301	423	1	259:1143–49	259:1143–49	X
dti-1301	423	2	.	.	PUNCT
dti-1301	424	1	drug	drug	NOUN
dti-1301	424	2	target	target	NOUN
dti-1301	424	3	insights	insight	NOUN
dti-1301	424	4	2007	2007	NUM
dti-1301	424	5	:	:	PUNCT
dti-1301	424	6	2	2	NUM
dti-1301	424	7	81	81	NUM
dti-1301	424	8	targeted	target	VERB
dti-1301	424	9	oral	oral	ADJ
dti-1301	424	10	drug	drug	NOUN
dti-1301	424	11	delivery	delivery	NOUN
dti-1301	424	12	reynolds	reynold	NOUN
dti-1301	424	13	,	,	PUNCT
dti-1301	424	14	j.e.f	j.e.f	PROPN
dti-1301	424	15	.	.	PROPN
dti-1301	424	16	1993	1993	NUM
dti-1301	424	17	.	.	PUNCT
dti-1301	425	1	magnesium	magnesium	NOUN
dti-1301	425	2	.	.	PUNCT
dti-1301	426	1	in	in	ADP
dti-1301	426	2	:	:	PUNCT
dti-1301	426	3	martindale	martindale	VERB
dti-1301	426	4	the	the	DET
dti-1301	426	5	extra	extra	ADJ
dti-1301	426	6	pharmacopoeia	pharmacopoeia	NOUN
dti-1301	426	7	.	.	PUNCT
dti-1301	427	1	30th	30th	ADJ
dti-1301	427	2	ed	ed	NOUN
dti-1301	427	3	.	.	PUNCT
dti-1301	428	1	the	the	DET
dti-1301	428	2	pharmaceutical	pharmaceutical	ADJ
dti-1301	428	3	press	press	NOUN
dti-1301	428	4	:	:	PUNCT
dti-1301	428	5	london	london	PROPN
dti-1301	428	6	p.	p.	PROPN
dti-1301	428	7	857	857	NUM
dti-1301	428	8	.	.	PUNCT
dti-1301	429	1	russel	russel	PROPN
dti-1301	429	2	-	-	PUNCT
dti-1301	429	3	jones	jones	PROPN
dti-1301	429	4	,	,	PUNCT
dti-1301	429	5	g.j	g.j	PROPN
dti-1301	429	6	.	.	PROPN
dti-1301	429	7	and	and	CCONJ
dti-1301	429	8	de	de	PROPN
dti-1301	429	9	aizpurua	aizpurua	PROPN
dti-1301	429	10	,	,	PUNCT
dti-1301	429	11	h.j	h.j	PROPN
dti-1301	429	12	.	.	PROPN
dti-1301	429	13	1988	1988	NUM
dti-1301	429	14	.	.	PUNCT
dti-1301	430	1	vitamin	vitamin	NOUN
dti-1301	430	2	b12	b12	NOUN
dti-1301	430	3	:	:	PUNCT
dti-1301	430	4	a	a	DET
dti-1301	430	5	novel	novel	ADJ
dti-1301	430	6	carrier	carrier	NOUN
dti-1301	430	7	for	for	ADP
dti-1301	430	8	orally	orally	ADV
dti-1301	430	9	presented	present	VERB
dti-1301	430	10	antigens	antigen	NOUN
dti-1301	430	11	.	.	PUNCT
dti-1301	431	1	proc	proc	NOUN
dti-1301	431	2	.	.	PUNCT
dti-1301	432	1	int	int	NOUN
dti-1301	432	2	.	.	PUNCT
dti-1301	433	1	symp	symp	PROPN
dti-1301	433	2	.	.	PUNCT
dti-1301	434	1	control	control	PROPN
dti-1301	434	2	rel	rel	PROPN
dti-1301	434	3	.	.	PUNCT
dti-1301	434	4	bioact	bioact	PROPN
dti-1301	434	5	.	.	PUNCT
dti-1301	435	1	mater	mater	NOUN
dti-1301	435	2	,	,	PUNCT
dti-1301	435	3	15:142–3	15:142–3	NUM
dti-1301	435	4	.	.	PUNCT
dti-1301	436	1	russel	russel	PROPN
dti-1301	436	2	-	-	PUNCT
dti-1301	436	3	jones	jones	PROPN
dti-1301	436	4	,	,	PUNCT
dti-1301	436	5	g.j	g.j	PROPN
dti-1301	436	6	.	.	PROPN
dti-1301	436	7	1995	1995	NUM
dti-1301	436	8	.	.	PUNCT
dti-1301	437	1	oral	oral	ADJ
dti-1301	437	2	delivery	delivery	NOUN
dti-1301	437	3	of	of	ADP
dti-1301	437	4	therapeutic	therapeutic	ADJ
dti-1301	437	5	proteins	protein	NOUN
dti-1301	437	6	and	and	CCONJ
dti-1301	437	7	peptides	peptide	NOUN
dti-1301	437	8	by	by	ADP
dti-1301	437	9	the	the	DET
dti-1301	437	10	vitamin	vitamin	NOUN
dti-1301	437	11	b12	b12	NOUN
dti-1301	437	12	uptake	uptake	ADJ
dti-1301	437	13	system	system	NOUN
dti-1301	437	14	.	.	PUNCT
dti-1301	438	1	in	in	ADP
dti-1301	438	2	:	:	PUNCT
dti-1301	438	3	taylor	taylor	PROPN
dti-1301	438	4	md	md	PROPN
dti-1301	438	5	,	,	PUNCT
dti-1301	438	6	amidon	amidon	PROPN
dti-1301	438	7	g	g	PROPN
dti-1301	438	8	,	,	PUNCT
dti-1301	438	9	eds	ed	NOUN
dti-1301	438	10	.	.	PUNCT
dti-1301	438	11	peptide	peptide	NOUN
dti-1301	438	12	-	-	PUNCT
dti-1301	438	13	based	base	VERB
dti-1301	438	14	drug	drug	NOUN
dti-1301	438	15	design	design	NOUN
dti-1301	438	16	:	:	PUNCT
dti-1301	438	17	controlling	control	VERB
dti-1301	438	18	transport	transport	NOUN
dti-1301	438	19	and	and	CCONJ
dti-1301	438	20	metabolism	metabolism	NOUN
dti-1301	438	21	,	,	PUNCT
dti-1301	438	22	acs	acs	PROPN
dti-1301	438	23	books	book	NOUN
dti-1301	438	24	,	,	PUNCT
dti-1301	438	25	washington	washington	PROPN
dti-1301	438	26	,	,	PUNCT
dti-1301	438	27	dc	dc	PROPN
dti-1301	438	28	,	,	PUNCT
dti-1301	438	29	pp	pp	ADP
dti-1301	438	30	181–98	181–98	NUM
dti-1301	438	31	.	.	PUNCT
dti-1301	439	1	russell	russell	PROPN
dti-1301	439	2	-	-	PUNCT
dti-1301	439	3	jones	jones	PROPN
dti-1301	439	4	,	,	PUNCT
dti-1301	439	5	g.j	g.j	PROPN
dti-1301	439	6	.	.	PROPN
dti-1301	439	7	2001	2001	NUM
dti-1301	439	8	.	.	PUNCT
dti-1301	440	1	the	the	DET
dti-1301	440	2	potential	potential	ADJ
dti-1301	440	3	use	use	NOUN
dti-1301	440	4	of	of	ADP
dti-1301	440	5	receptor	receptor	NOUN
dti-1301	440	6	-	-	PUNCT
dti-1301	440	7	mediated	mediate	VERB
dti-1301	440	8	endocytosis	endocytosis	NOUN
dti-1301	440	9	for	for	ADP
dti-1301	440	10	oral	oral	ADJ
dti-1301	440	11	drug	drug	NOUN
dti-1301	440	12	delivery	delivery	NOUN
dti-1301	440	13	.	.	PUNCT
dti-1301	441	1	adv	adv	PROPN
dti-1301	441	2	.	.	PUNCT
dti-1301	441	3	drug	drug	PROPN
dti-1301	441	4	deliv	deliv	PROPN
dti-1301	441	5	.	.	PUNCT
dti-1301	442	1	rev	rev	PROPN
dti-1301	442	2	.	.	PROPN
dti-1301	442	3	,	,	PUNCT
dti-1301	442	4	46:59–73	46:59–73	NUM
dti-1301	442	5	.	.	PUNCT
dti-1301	443	1	schohn	schohn	NOUN
dti-1301	443	2	,	,	PUNCT
dti-1301	443	3	h.	h.	PROPN
dti-1301	443	4	,	,	PUNCT
dti-1301	443	5	guéant	guéant	NOUN
dti-1301	443	6	,	,	PUNCT
dti-1301	443	7	j.l	j.l	PROPN
dti-1301	443	8	.	.	PROPN
dti-1301	443	9	and	and	CCONJ
dti-1301	443	10	girr	girr	PROPN
dti-1301	443	11	,	,	PUNCT
dti-1301	443	12	m.	m.	NOUN
dti-1301	443	13	et	et	PROPN
dti-1301	443	14	al	al	PROPN
dti-1301	443	15	.	.	PROPN
dti-1301	443	16	1991	1991	NUM
dti-1301	443	17	.	.	PUNCT
dti-1301	444	1	synthesis	synthesis	NOUN
dti-1301	444	2	and	and	CCONJ
dti-1301	444	3	secretion	secretion	NOUN
dti-1301	444	4	of	of	ADP
dti-1301	444	5	a	a	DET
dti-1301	444	6	cobalamin	cobalamin	NOUN
dti-1301	444	7	-	-	PUNCT
dti-1301	444	8	binding	bind	VERB
dti-1301	444	9	protein	protein	NOUN
dti-1301	444	10	by	by	ADP
dti-1301	444	11	ht	ht	PROPN
dti-1301	444	12	29	29	NUM
dti-1301	444	13	cell	cell	NOUN
dti-1301	444	14	line	line	NOUN
dti-1301	444	15	.	.	PUNCT
dti-1301	445	1	biochem	biochem	PROPN
dti-1301	445	2	.	.	PUNCT
dti-1301	446	1	j.	j.	PROPN
dti-1301	446	2	,	,	PUNCT
dti-1301	446	3	280:427–30	280:427–30	PROPN
dti-1301	446	4	.	.	PUNCT
dti-1301	447	1	shen	shen	PROPN
dti-1301	447	2	,	,	PUNCT
dti-1301	447	3	w.	w.	PROPN
dti-1301	447	4	,	,	PUNCT
dti-1301	447	5	wan	wan	PROPN
dti-1301	447	6	,	,	PUNCT
dti-1301	447	7	j.	j.	PROPN
dti-1301	447	8	and	and	CCONJ
dti-1301	447	9	ekrami	ekrami	PROPN
dti-1301	447	10	,	,	PUNCT
dti-1301	447	11	h.	h.	PROPN
dti-1301	447	12	1992	1992	NUM
dti-1301	447	13	.	.	PUNCT
dti-1301	448	1	enhancement	enhancement	NOUN
dti-1301	448	2	of	of	ADP
dti-1301	448	3	polypeptide	polypeptide	ADJ
dti-1301	448	4	and	and	CCONJ
dti-1301	448	5	protein	protein	NOUN
dti-1301	448	6	absorption	absorption	NOUN
dti-1301	448	7	by	by	ADP
dti-1301	448	8	macromolecular	macromolecular	NOUN
dti-1301	448	9	carriers	carrier	NOUN
dti-1301	448	10	via	via	ADP
dti-1301	448	11	endocytosis	endocytosis	NOUN
dti-1301	448	12	and	and	CCONJ
dti-1301	448	13	transcytosis	transcytosis	NOUN
dti-1301	448	14	.	.	PUNCT
dti-1301	449	1	adv	adv	PROPN
dti-1301	449	2	.	.	PUNCT
dti-1301	449	3	drug	drug	PROPN
dti-1301	449	4	deliv	deliv	PROPN
dti-1301	449	5	.	.	PUNCT
dti-1301	450	1	rev	rev	PROPN
dti-1301	450	2	.	.	PROPN
dti-1301	450	3	,	,	PUNCT
dti-1301	450	4	8:93–113	8:93–113	NUM
dti-1301	450	5	.	.	PUNCT
dti-1301	451	1	simons	simon	NOUN
dti-1301	451	2	,	,	PUNCT
dti-1301	451	3	k.	k.	PROPN
dti-1301	451	4	and	and	CCONJ
dti-1301	451	5	fuller	full	ADJ
dti-1301	451	6	,	,	PUNCT
dti-1301	451	7	s.d	s.d	PROPN
dti-1301	451	8	.	.	PROPN
dti-1301	451	9	1985	1985	NUM
dti-1301	451	10	.	.	PUNCT
dti-1301	452	1	cell	cell	NOUN
dti-1301	452	2	surface	surface	NOUN
dti-1301	452	3	polarity	polarity	NOUN
dti-1301	452	4	in	in	ADP
dti-1301	452	5	epithelia	epithelia	PROPN
dti-1301	452	6	.	.	PUNCT
dti-1301	453	1	annu	annu	PROPN
dti-1301	453	2	.	.	PUNCT
dti-1301	454	1	rev	rev	PROPN
dti-1301	454	2	.	.	PROPN
dti-1301	454	3	cell	cell	NOUN
dti-1301	454	4	.	.	PUNCT
dti-1301	455	1	biol	biol	PROPN
dti-1301	455	2	.	.	PUNCT
dti-1301	455	3	,	,	PUNCT
dti-1301	455	4	1:243–48	1:243–48	PROPN
dti-1301	455	5	.	.	PROPN
dti-1301	455	6	steffansen	steffansen	PROPN
dti-1301	455	7	,	,	PUNCT
dti-1301	455	8	b.	b.	PROPN
dti-1301	455	9	,	,	PUNCT
dti-1301	455	10	nielsen	nielsen	PROPN
dti-1301	455	11	,	,	PUNCT
dti-1301	455	12	c.u	c.u	PROPN
dti-1301	455	13	.	.	PROPN
dti-1301	455	14	and	and	CCONJ
dti-1301	455	15	brodin	brodin	PROPN
dti-1301	455	16	,	,	PUNCT
dti-1301	455	17	b.	b.	PROPN
dti-1301	455	18	et	et	PROPN
dti-1301	455	19	al	al	PROPN
dti-1301	455	20	.	.	PROPN
dti-1301	455	21	2004	2004	NUM
dti-1301	455	22	.	.	PUNCT
dti-1301	456	1	intestinal	intestinal	ADJ
dti-1301	456	2	solute	solute	NOUN
dti-1301	456	3	carriers	carrier	NOUN
dti-1301	456	4	:	:	PUNCT
dti-1301	456	5	an	an	DET
dti-1301	456	6	overview	overview	NOUN
dti-1301	456	7	of	of	ADP
dti-1301	456	8	trends	trend	NOUN
dti-1301	456	9	and	and	CCONJ
dti-1301	456	10	strategies	strategy	NOUN
dti-1301	456	11	for	for	ADP
dti-1301	456	12	improving	improve	VERB
dti-1301	456	13	oral	oral	ADJ
dti-1301	456	14	drug	drug	NOUN
dti-1301	456	15	absorption	absorption	NOUN
dti-1301	456	16	.	.	PUNCT
dti-1301	457	1	eur	eur	PROPN
dti-1301	457	2	.	.	PUNCT
dti-1301	458	1	j.	j.	PROPN
dti-1301	458	2	pharm	pharm	PROPN
dti-1301	458	3	.	.	PUNCT
dti-1301	459	1	biopharm	biopharm	PROPN
dti-1301	459	2	.	.	PUNCT
dti-1301	459	3	,	,	PUNCT
dti-1301	459	4	21:3–16	21:3–16	NUM
dti-1301	459	5	.	.	PUNCT
dti-1301	460	1	steffansen	steffansen	PROPN
dti-1301	460	2	,	,	PUNCT
dti-1301	460	3	b.	b.	PROPN
dti-1301	460	4	,	,	PUNCT
dti-1301	460	5	nielsen	nielsen	PROPN
dti-1301	460	6	,	,	PUNCT
dti-1301	460	7	c.u	c.u	PROPN
dti-1301	460	8	.	.	PROPN
dti-1301	460	9	and	and	CCONJ
dti-1301	460	10	frokjaer	frokjaer	NOUN
dti-1301	460	11	,	,	PUNCT
dti-1301	460	12	s.	s.	PROPN
dti-1301	460	13	2005	2005	NUM
dti-1301	460	14	.	.	PUNCT
dti-1301	461	1	delivery	delivery	NOUN
dti-1301	461	2	aspects	aspect	NOUN
dti-1301	461	3	of	of	ADP
dti-1301	461	4	small	small	ADJ
dti-1301	461	5	peptides	peptide	NOUN
dti-1301	461	6	and	and	CCONJ
dti-1301	461	7	substrates	substrate	NOUN
dti-1301	461	8	for	for	ADP
dti-1301	461	9	peptide	peptide	ADJ
dti-1301	461	10	transporters	transporter	NOUN
dti-1301	461	11	.	.	PUNCT
dti-1301	462	1	eur	eur	PROPN
dti-1301	462	2	.	.	PUNCT
dti-1301	463	1	j.	j.	PROPN
dti-1301	463	2	pharm	pharm	PROPN
dti-1301	463	3	.	.	PUNCT
dti-1301	464	1	biopharm	biopharm	PROPN
dti-1301	464	2	.	.	PUNCT
dti-1301	464	3	,	,	PUNCT
dti-1301	464	4	60:241–5	60:241–5	NUM
dti-1301	464	5	.	.	PUNCT
dti-1301	464	6	steubel	steubel	PROPN
dti-1301	464	7	,	,	PUNCT
dti-1301	464	8	a.	a.	PROPN
dti-1301	464	9	,	,	PUNCT
dti-1301	464	10	siepmann	siepmann	PROPN
dti-1301	464	11	,	,	PUNCT
dti-1301	464	12	j.	j.	PROPN
dti-1301	464	13	and	and	CCONJ
dti-1301	464	14	bodmeier	bodmeier	PROPN
dti-1301	464	15	,	,	PUNCT
dti-1301	464	16	r.	r.	PROPN
dti-1301	464	17	2006	2006	NUM
dti-1301	464	18	.	.	PUNCT
dti-1301	465	1	gastroretentive	gastroretentive	ADJ
dti-1301	465	2	drug	drug	NOUN
dti-1301	465	3	delivery	delivery	NOUN
dti-1301	465	4	systems	system	NOUN
dti-1301	465	5	.	.	PUNCT
dti-1301	466	1	expert	expert	NOUN
dti-1301	466	2	opin	opin	NOUN
dti-1301	466	3	.	.	PUNCT
dti-1301	467	1	drug	drug	NOUN
dti-1301	467	2	deliv	deliv	NOUN
dti-1301	467	3	.	.	PUNCT
dti-1301	467	4	,	,	PUNCT
dti-1301	467	5	3(2):217–33	3(2):217–33	X
dti-1301	467	6	.	.	PUNCT
dti-1301	468	1	varma	varma	PROPN
dti-1301	468	2	,	,	PUNCT
dti-1301	468	3	m.v.s	m.v.s	PROPN
dti-1301	468	4	.	.	PROPN
dti-1301	468	5	,	,	PUNCT
dti-1301	468	6	perumal	perumal	PROPN
dti-1301	468	7	,	,	PUNCT
dti-1301	468	8	o.p	o.p	PROPN
dti-1301	468	9	.	.	PROPN
dti-1301	468	10	and	and	CCONJ
dti-1301	468	11	panchagnula	panchagnula	PROPN
dti-1301	468	12	,	,	PUNCT
dti-1301	468	13	r.	r.	PROPN
dti-1301	468	14	2006	2006	NUM
dti-1301	468	15	.	.	PUNCT
dti-1301	469	1	functional	functional	ADJ
dti-1301	469	2	role	role	NOUN
dti-1301	469	3	of	of	ADP
dti-1301	469	4	p	p	NOUN
dti-1301	469	5	-	-	PUNCT
dti-1301	469	6	glycoprotein	glycoprotein	NOUN
dti-1301	469	7	in	in	ADP
dti-1301	469	8	limiting	limit	VERB
dti-1301	469	9	peroral	peroral	ADJ
dti-1301	469	10	drug	drug	NOUN
dti-1301	469	11	absorption	absorption	NOUN
dti-1301	469	12	:	:	PUNCT
dti-1301	469	13	optimizing	optimize	VERB
dti-1301	469	14	drug	drug	NOUN
dti-1301	469	15	delivery	delivery	NOUN
dti-1301	469	16	.	.	PUNCT
dti-1301	470	1	curr	curr	PROPN
dti-1301	470	2	.	.	PUNCT
dti-1301	471	1	opin	opin	NOUN
dti-1301	471	2	.	.	PUNCT
dti-1301	472	1	chem	chem	NOUN
dti-1301	472	2	.	.	PUNCT
dti-1301	473	1	biol	biol	PROPN
dti-1301	473	2	.	.	PUNCT
dti-1301	473	3	,	,	PUNCT
dti-1301	473	4	10:367–73	10:367–73	PROPN
dti-1301	473	5	.	.	PUNCT
dti-1301	474	1	varma	varma	PROPN
dti-1301	474	2	,	,	PUNCT
dti-1301	474	3	m.v.s	m.v.s	PROPN
dti-1301	474	4	.	.	PROPN
dti-1301	474	5	,	,	PUNCT
dti-1301	474	6	ashokraj	ashokraj	ADJ
dti-1301	474	7	,	,	PUNCT
dti-1301	474	8	y.	y.	PROPN
dti-1301	474	9	and	and	CCONJ
dti-1301	474	10	dey	dey	PROPN
dti-1301	474	11	,	,	PUNCT
dti-1301	474	12	c.s	c.s	PROPN
dti-1301	474	13	.	.	PROPN
dti-1301	474	14	et	et	PROPN
dti-1301	474	15	al	al	PROPN
dti-1301	474	16	.	.	PROPN
dti-1301	474	17	2003	2003	NUM
dti-1301	474	18	.	.	PUNCT
dti-1301	475	1	p	p	X
dti-1301	475	2	-	-	PUNCT
dti-1301	475	3	glycoprotein	glycoprotein	NOUN
dti-1301	475	4	inhibitors	inhibitor	NOUN
dti-1301	475	5	and	and	CCONJ
dti-1301	475	6	their	their	PRON
dti-1301	475	7	screening	screening	NOUN
dti-1301	475	8	:	:	PUNCT
dti-1301	475	9	a	a	DET
dti-1301	475	10	perspective	perspective	NOUN
dti-1301	475	11	from	from	ADP
dti-1301	475	12	bioavailability	bioavailability	NOUN
dti-1301	475	13	enhancement	enhancement	NOUN
dti-1301	475	14	.	.	PUNCT
dti-1301	476	1	pharmacol	pharmacol	PROPN
dti-1301	476	2	.	.	PUNCT
dti-1301	477	1	res	re	NOUN
dti-1301	477	2	.	.	PROPN
dti-1301	477	3	,	,	PUNCT
dti-1301	477	4	48:347–359	48:347–359	PROPN
dti-1301	477	5	.	.	PUNCT
dti-1301	478	1	vyas	vyas	PROPN
dti-1301	478	2	,	,	PUNCT
dti-1301	478	3	s.p	s.p	PROPN
dti-1301	478	4	.	.	PROPN
dti-1301	478	5	and	and	CCONJ
dti-1301	478	6	sihorkar	sihorkar	PROPN
dti-1301	478	7	,	,	PUNCT
dti-1301	478	8	v.	v.	ADP
dti-1301	478	9	2000	2000	NUM
dti-1301	478	10	.	.	PUNCT
dti-1301	479	1	endogenous	endogenous	ADJ
dti-1301	479	2	carriers	carrier	NOUN
dti-1301	479	3	and	and	CCONJ
dti-1301	479	4	ligands	ligand	NOUN
dti-1301	479	5	in	in	ADP
dti-1301	479	6	nonimmunogenic	nonimmunogenic	NOUN
dti-1301	479	7	site	site	PROPN
dti-1301	479	8	-	-	PUNCT
dti-1301	479	9	specifi	specifi	PROPN
dti-1301	479	10	c	c	PROPN
dti-1301	479	11	drug	drug	NOUN
dti-1301	479	12	delivery	delivery	NOUN
dti-1301	479	13	.	.	PUNCT
dti-1301	480	1	adv	adv	PROPN
dti-1301	480	2	.	.	PUNCT
dti-1301	480	3	drug	drug	PROPN
dti-1301	480	4	deliv	deliv	PROPN
dti-1301	480	5	.	.	PUNCT
dti-1301	481	1	rev	rev	PROPN
dti-1301	481	2	.	.	PROPN
dti-1301	481	3	,	,	PUNCT
dti-1301	481	4	43:101–164	43:101–164	PROPN
dti-1301	481	5	.	.	PUNCT
dti-1301	482	1	wagner	wagner	PROPN
dti-1301	482	2	,	,	PUNCT
dti-1301	482	3	e.	e.	PROPN
dti-1301	482	4	,	,	PUNCT
dti-1301	482	5	zenke	zenke	NOUN
dti-1301	482	6	,	,	PUNCT
dti-1301	482	7	m.	m.	NOUN
dti-1301	482	8	and	and	CCONJ
dti-1301	482	9	cotten	cotten	PROPN
dti-1301	482	10	,	,	PUNCT
dti-1301	482	11	m.	m.	NOUN
dti-1301	482	12	et	et	PROPN
dti-1301	482	13	al	al	PROPN
dti-1301	482	14	.	.	PROPN
dti-1301	482	15	1990	1990	NUM
dti-1301	482	16	.	.	PUNCT
dti-1301	483	1	transferrin	transferrin	NOUN
dti-1301	483	2	-	-	PUNCT
dti-1301	483	3	polycation	polycation	NOUN
dti-1301	483	4	conjugates	conjugate	NOUN
dti-1301	483	5	as	as	SCONJ
dti-1301	483	6	carriers	carrier	NOUN
dti-1301	483	7	for	for	ADP
dti-1301	483	8	dna	dna	NOUN
dti-1301	483	9	uptake	uptake	ADJ
dti-1301	483	10	into	into	ADP
dti-1301	483	11	cells	cell	NOUN
dti-1301	483	12	.	.	PUNCT
dti-1301	484	1	used	use	VERB
dti-1301	484	2	to	to	PART
dti-1301	484	3	select	select	VERB
dti-1301	484	4	receptor	receptor	NOUN
dti-1301	484	5	-	-	PUNCT
dti-1301	484	6	modifi	modifi	NOUN
dti-1301	484	7	ed	ed	PROPN
dti-1301	484	8	cells	cell	NOUN
dti-1301	484	9	.	.	PUNCT
dti-1301	485	1	proc	proc	NOUN
dti-1301	485	2	.	.	PUNCT
dti-1301	486	1	natl	natl	PROPN
dti-1301	486	2	.	.	PUNCT
dti-1301	487	1	acad	acad	PROPN
dti-1301	487	2	.	.	PUNCT
dti-1301	488	1	sci	sci	PROPN
dti-1301	488	2	.	.	PUNCT
dti-1301	488	3	u.s.a	u.s.a	PROPN
dti-1301	488	4	.	.	PROPN
dti-1301	488	5	,	,	PUNCT
dti-1301	488	6	87:3410–14	87:3410–14	NUM
dti-1301	488	7	.	.	PUNCT
dti-1301	489	1	wan	wan	PROPN
dti-1301	489	2	,	,	PUNCT
dti-1301	489	3	j.	j.	PROPN
dti-1301	489	4	and	and	CCONJ
dti-1301	489	5	shen	shen	PROPN
dti-1301	489	6	,	,	PUNCT
dti-1301	489	7	w.c	w.c	PROPN
dti-1301	489	8	.	.	PROPN
dti-1301	489	9	1990	1990	NUM
dti-1301	489	10	.	.	PUNCT
dti-1301	490	1	transcytosis	transcytosis	NOUN
dti-1301	490	2	of	of	ADP
dti-1301	490	3	transferring	transferring	NOUN
dti-1301	490	4	is	be	AUX
dti-1301	490	5	enhanced	enhance	VERB
dti-1301	490	6	by	by	ADP
dti-1301	490	7	monensin	monensin	NOUN
dti-1301	490	8	in	in	ADP
dti-1301	490	9	fi	fi	NOUN
dti-1301	490	10	lter	lter	NOUN
dti-1301	490	11	grown	grow	VERB
dti-1301	490	12	mdck	mdck	ADJ
dti-1301	490	13	epithelial	epithelial	ADJ
dti-1301	490	14	cells	cell	NOUN
dti-1301	490	15	.	.	PUNCT
dti-1301	491	1	j.	j.	PROPN
dti-1301	491	2	cell	cell	PROPN
dti-1301	491	3	biol	biol	PROPN
dti-1301	491	4	.	.	PUNCT
dti-1301	491	5	,	,	PUNCT
dti-1301	491	6	111:83a	111:83a	X
dti-1301	491	7	.	.	PUNCT
dti-1301	492	1	wan	wan	PROPN
dti-1301	492	2	,	,	PUNCT
dti-1301	492	3	j.	j.	PROPN
dti-1301	492	4	,	,	PUNCT
dti-1301	492	5	shah	shah	PROPN
dti-1301	492	6	,	,	PUNCT
dti-1301	492	7	d.	d.	PROPN
dti-1301	492	8	and	and	CCONJ
dti-1301	492	9	shen	shen	PROPN
dti-1301	492	10	,	,	PUNCT
dti-1301	492	11	w.c	w.c	PROPN
dti-1301	492	12	.	.	PROPN
dti-1301	492	13	1991	1991	NUM
dti-1301	492	14	.	.	PUNCT
dti-1301	493	1	brefeldin	brefeldin	VERB
dti-1301	493	2	a	a	DET
dti-1301	493	3	(	(	PUNCT
dti-1301	493	4	bfa	bfa	PROPN
dti-1301	493	5	)	)	PUNCT
dti-1301	493	6	induces	induce	VERB
dti-1301	493	7	missorting	missorte	VERB
dti-1301	493	8	of	of	ADP
dti-1301	493	9	transferrin	transferrin	NOUN
dti-1301	493	10	receptors	receptor	NOUN
dti-1301	493	11	(	(	PUNCT
dti-1301	493	12	tfr	tfr	NOUN
dti-1301	493	13	)	)	PUNCT
dti-1301	493	14	and	and	CCONJ
dti-1301	493	15	increases	increase	VERB
dti-1301	493	16	receptor	receptor	NOUN
dti-1301	493	17	-	-	PUNCT
dti-1301	493	18	mediated	mediate	VERB
dti-1301	493	19	transcytosis	transcytosis	NOUN
dti-1301	493	20	of	of	ADP
dti-1301	493	21	transferrin	transferrin	NOUN
dti-1301	493	22	(	(	PUNCT
dti-1301	493	23	tf	tf	INTJ
dti-1301	493	24	)	)	PUNCT
dti-1301	493	25	in	in	ADP
dti-1301	493	26	fi	fi	NOUN
dti-1301	493	27	lter	lter	NOUN
dti-1301	493	28	grown	grow	VERB
dti-1301	493	29	mdck	mdck	PROPN
dti-1301	493	30	cells	cell	NOUN
dti-1301	493	31	.	.	PUNCT
dti-1301	494	1	j.	j.	PROPN
dti-1301	494	2	cell	cell	PROPN
dti-1301	494	3	biol	biol	PROPN
dti-1301	494	4	.	.	PUNCT
dti-1301	494	5	,	,	PUNCT
dti-1301	494	6	115:259a	115:259a	X
dti-1301	494	7	.	.	PUNCT
dti-1301	495	1	ward	ward	PROPN
dti-1301	495	2	,	,	PUNCT
dti-1301	495	3	c.m	c.m	PROPN
dti-1301	495	4	.	.	PROPN
dti-1301	495	5	2000	2000	NUM
dti-1301	495	6	.	.	PUNCT
dti-1301	496	1	folate	folate	NOUN
dti-1301	496	2	-	-	PUNCT
dti-1301	496	3	targeted	target	VERB
dti-1301	496	4	non	non	ADJ
dti-1301	496	5	-	-	ADJ
dti-1301	496	6	viral	viral	ADJ
dti-1301	496	7	dna	dna	NOUN
dti-1301	496	8	vectors	vector	NOUN
dti-1301	496	9	for	for	ADP
dti-1301	496	10	cancer	cancer	NOUN
dti-1301	496	11	gene	gene	NOUN
dti-1301	496	12	therapy	therapy	NOUN
dti-1301	496	13	.	.	PUNCT
dti-1301	497	1	curr	curr	PROPN
dti-1301	497	2	.	.	PUNCT
dti-1301	498	1	opin	opin	NOUN
dti-1301	498	2	.	.	PUNCT
dti-1301	499	1	mol	mol	PROPN
dti-1301	499	2	.	.	PROPN
dti-1301	500	1	ther	ther	PROPN
dti-1301	500	2	.	.	PUNCT
dti-1301	500	3	,	,	PUNCT
dti-1301	500	4	2:182–187	2:182–187	NUM
dti-1301	500	5	.	.	PUNCT
dti-1301	501	1	weidner	weidner	PROPN
dti-1301	501	2	,	,	PUNCT
dti-1301	501	3	j.	j.	PROPN
dti-1301	501	4	2001	2001	NUM
dti-1301	501	5	.	.	PUNCT
dti-1301	502	1	drug	drug	NOUN
dti-1301	502	2	delivery	delivery	NOUN
dti-1301	502	3	drug	drug	NOUN
dti-1301	502	4	discov	discov	NOUN
dti-1301	502	5	.	.	PUNCT
dti-1301	503	1	today	today	NOUN
dti-1301	503	2	,	,	PUNCT
dti-1301	503	3	6(19):1028–9	6(19):1028–9	NOUN
dti-1301	503	4	.	.	PUNCT
dti-1301	503	5	woodley	woodley	NOUN
dti-1301	503	6	,	,	PUNCT
dti-1301	503	7	j.f	j.f	PROPN
dti-1301	503	8	.	.	PROPN
dti-1301	503	9	and	and	CCONJ
dti-1301	503	10	naisbett	naisbett	PROPN
dti-1301	503	11	,	,	PUNCT
dti-1301	503	12	b.	b.	PROPN
dti-1301	504	1	the	the	DET
dti-1301	504	2	potential	potential	NOUN
dti-1301	504	3	for	for	ADP
dti-1301	504	4	delaying	delay	VERB
dti-1301	504	5	the	the	DET
dti-1301	504	6	gastro	gastro	ADJ
dti-1301	504	7	-	-	PUNCT
dti-1301	504	8	intestinal	intestinal	ADJ
dti-1301	504	9	transit	transit	NOUN
dti-1301	504	10	of	of	ADP
dti-1301	504	11	drugs	drug	NOUN
dti-1301	504	12	.	.	PUNCT
dti-1301	505	1	proc	proc	NOUN
dti-1301	505	2	.	.	PUNCT
dti-1301	506	1	int	int	NOUN
dti-1301	506	2	.	.	PUNCT
dti-1301	507	1	sym	sym	PROPN
dti-1301	507	2	.	.	PROPN
dti-1301	507	3	control	control	PROPN
dti-1301	507	4	rel	rel	PROPN
dti-1301	507	5	.	.	PUNCT
dti-1301	507	6	bioact	bioact	PROPN
dti-1301	507	7	.	.	PUNCT
dti-1301	508	1	mater	mater	PROPN
dti-1301	508	2	.	.	PROPN
dti-1301	508	3	,	,	PUNCT
dti-1301	508	4	15	15	NUM
dti-1301	508	5	(	(	PUNCT
dti-1301	508	6	1988	1988	NUM
dti-1301	508	7	)	)	PUNCT
dti-1301	509	1	125–126	125–126	NUM
dti-1301	509	2	.	.	PUNCT
dti-1301	510	1	xu	xu	PROPN
dti-1301	510	2	,	,	PUNCT
dti-1301	510	3	l.	l.	PROPN
dti-1301	510	4	,	,	PUNCT
dti-1301	510	5	tang	tang	PROPN
dti-1301	510	6	,	,	PUNCT
dti-1301	510	7	w.h	w.h	PROPN
dti-1301	510	8	.	.	PROPN
dti-1301	510	9	and	and	CCONJ
dti-1301	510	10	huang	huang	PROPN
dti-1301	510	11	,	,	PUNCT
dti-1301	510	12	c.c	c.c	PROPN
dti-1301	510	13	.	.	PROPN
dti-1301	510	14	2001	2001	NUM
dti-1301	510	15	.	.	PUNCT
dti-1301	511	1	systemic	systemic	ADJ
dti-1301	511	2	p53	p53	NOUN
dti-1301	511	3	gene	gene	NOUN
dti-1301	511	4	therapy	therapy	NOUN
dti-1301	511	5	of	of	ADP
dti-1301	511	6	cancer	cancer	NOUN
dti-1301	511	7	with	with	ADP
dti-1301	511	8	immunolipoplexes	immunolipoplexe	NOUN
dti-1301	511	9	targeted	target	VERB
dti-1301	511	10	by	by	ADP
dti-1301	511	11	anti	anti	ADJ
dti-1301	511	12	-	-	ADJ
dti-1301	511	13	transferrin	transferrin	ADJ
dti-1301	511	14	receptor	receptor	NOUN
dti-1301	511	15	scfz	scfz	NOUN
dti-1301	511	16	.	.	PUNCT
dti-1301	512	1	mol	mol	PROPN
dti-1301	512	2	.	.	PROPN
dti-1301	512	3	med	med	PROPN
dti-1301	512	4	.	.	PROPN
dti-1301	513	1	,	,	PUNCT
dti-1301	513	2	7:723–34	7:723–34	X
dti-1301	513	3	.	.	PUNCT
dti-1301	514	1	zhang	zhang	PROPN
dti-1301	514	2	,	,	PUNCT
dti-1301	514	3	e.y	e.y	PROPN
dti-1301	514	4	.	.	PROPN
dti-1301	514	5	,	,	PUNCT
dti-1301	514	6	phelps	phelps	PROPN
dti-1301	514	7	,	,	PUNCT
dti-1301	515	1	m.a	m.a	PROPN
dti-1301	515	2	.	.	PROPN
dti-1301	515	3	and	and	CCONJ
dti-1301	515	4	cheng	cheng	PROPN
dti-1301	515	5	,	,	PUNCT
dti-1301	515	6	c.	c.	PROPN
dti-1301	515	7	et	et	PROPN
dti-1301	515	8	al	al	PROPN
dti-1301	515	9	.	.	PROPN
dti-1301	515	10	2002	2002	NUM
dti-1301	515	11	.	.	PUNCT
dti-1301	516	1	modeling	modeling	NOUN
dti-1301	516	2	of	of	ADP
dti-1301	516	3	active	active	ADJ
dti-1301	516	4	transport	transport	NOUN
dti-1301	516	5	systems	system	NOUN
dti-1301	516	6	.	.	PUNCT
dti-1301	517	1	adv	adv	PROPN
dti-1301	517	2	.	.	PUNCT
dti-1301	517	3	drug	drug	PROPN
dti-1301	517	4	deliv	deliv	PROPN
dti-1301	517	5	.	.	PUNCT
dti-1301	518	1	rev	rev	PROPN
dti-1301	518	2	.	.	PROPN
dti-1301	518	3	,	,	PUNCT
dti-1301	518	4	54:329–54	54:329–54	NUM
dti-1301	518	5	.	.	PUNCT