id	sid	tid	token	lemma	pos
dti-1304	1	1	kameda	kameda	PROPN
dti-1304	1	2	et	et	PROPN
dti-1304	1	3	al.indd	al.indd	PROPN
dti-1304	1	4	drug	drug	NOUN
dti-1304	1	5	target	target	NOUN
dti-1304	1	6	insights	insight	NOUN
dti-1304	1	7	2007:2	2007:2	NUM
dti-1304	1	8	239–247	239–247	NUM
dti-1304	1	9	239	239	NUM
dti-1304	1	10	review	review	NOUN
dti-1304	1	11	correspondence	correspondence	NOUN
dti-1304	1	12	:	:	PUNCT
dti-1304	1	13	hideto	hideto	PROPN
dti-1304	1	14	kameda	kameda	PROPN
dti-1304	1	15	,	,	PUNCT
dti-1304	1	16	m.d./ph.d	m.d./ph.d	PROPN
dti-1304	1	17	.	.	PROPN
dti-1304	1	18	,	,	PUNCT
dti-1304	1	19	division	division	NOUN
dti-1304	1	20	of	of	ADP
dti-1304	1	21	rheumatology	rheumatology	NOUN
dti-1304	1	22	/	/	SYM
dti-1304	1	23	clinical	clinical	ADJ
dti-1304	1	24	immunology	immunology	NOUN
dti-1304	1	25	,	,	PUNCT
dti-1304	1	26	department	department	NOUN
dti-1304	1	27	of	of	ADP
dti-1304	1	28	internal	internal	ADJ
dti-1304	1	29	medicine	medicine	NOUN
dti-1304	1	30	,	,	PUNCT
dti-1304	1	31	saitama	saitama	PROPN
dti-1304	1	32	medical	medical	ADJ
dti-1304	1	33	center	center	NOUN
dti-1304	1	34	,	,	PUNCT
dti-1304	1	35	saitama	saitama	PROPN
dti-1304	1	36	medical	medical	PROPN
dti-1304	1	37	university	university	PROPN
dti-1304	1	38	,	,	PUNCT
dti-1304	1	39	1981	1981	NUM
dti-1304	1	40	kamoda	kamoda	NOUN
dti-1304	1	41	,	,	PUNCT
dti-1304	1	42	tsujido	tsujido	PROPN
dti-1304	1	43	-	-	PUNCT
dti-1304	1	44	machi	machi	NOUN
dti-1304	1	45	,	,	PUNCT
dti-1304	1	46	kawagoe	kawagoe	ADJ
dti-1304	1	47	,	,	PUNCT
dti-1304	1	48	saitama	saitama	PROPN
dti-1304	1	49	350	350	NUM
dti-1304	1	50	-	-	PUNCT
dti-1304	1	51	8550	8550	NUM
dti-1304	1	52	,	,	PUNCT
dti-1304	1	53	japan	japan	PROPN
dti-1304	1	54	.	.	PUNCT
dti-1304	2	1	tel	tel	PROPN
dti-1304	2	2	/	/	SYM
dti-1304	2	3	fax	fax	NOUN
dti-1304	2	4	:	:	PUNCT
dti-1304	2	5	+81	+81	NUM
dti-1304	2	6	-	-	PUNCT
dti-1304	2	7	49	49	NUM
dti-1304	2	8	-	-	PUNCT
dti-1304	2	9	228	228	NUM
dti-1304	2	10	-	-	PUNCT
dti-1304	2	11	3574	3574	NUM
dti-1304	2	12	;	;	PUNCT
dti-1304	2	13	email	email	NOUN
dti-1304	2	14	:	:	PUNCT
dti-1304	2	15	kamehide@saitama-med.ac.jp	kamehide@saitama-med.ac.jp	VERB
dti-1304	2	16	copyright	copyright	NOUN
dti-1304	2	17	in	in	ADP
dti-1304	2	18	this	this	DET
dti-1304	2	19	article	article	NOUN
dti-1304	2	20	,	,	PUNCT
dti-1304	2	21	its	its	PRON
dti-1304	2	22	metadata	metadata	NOUN
dti-1304	2	23	,	,	PUNCT
dti-1304	2	24	and	and	CCONJ
dti-1304	2	25	any	any	DET
dti-1304	2	26	supplementary	supplementary	ADJ
dti-1304	2	27	data	datum	NOUN
dti-1304	2	28	is	be	AUX
dti-1304	2	29	held	hold	VERB
dti-1304	2	30	by	by	ADP
dti-1304	2	31	its	its	PRON
dti-1304	2	32	author	author	NOUN
dti-1304	2	33	or	or	CCONJ
dti-1304	2	34	authors	author	NOUN
dti-1304	2	35	.	.	PUNCT
dti-1304	3	1	it	it	PRON
dti-1304	3	2	is	be	AUX
dti-1304	3	3	published	publish	VERB
dti-1304	3	4	under	under	ADP
dti-1304	3	5	the	the	DET
dti-1304	3	6	creative	creative	ADJ
dti-1304	3	7	commons	common	NOUN
dti-1304	3	8	attribution	attribution	NOUN
dti-1304	3	9	by	by	ADP
dti-1304	3	10	licence	licence	NOUN
dti-1304	3	11	.	.	PUNCT
dti-1304	4	1	for	for	SCONJ
dti-1304	4	2	further	further	ADJ
dti-1304	4	3	information	information	NOUN
dti-1304	4	4	go	go	VERB
dti-1304	4	5	to	to	ADP
dti-1304	4	6	:	:	PUNCT
dti-1304	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1304	4	8	platelet	platelet	NOUN
dti-1304	4	9	-	-	PUNCT
dti-1304	4	10	derived	derive	VERB
dti-1304	4	11	growth	growth	NOUN
dti-1304	4	12	factor	factor	NOUN
dti-1304	4	13	as	as	ADP
dti-1304	4	14	a	a	DET
dti-1304	4	15	therapeutic	therapeutic	ADJ
dti-1304	4	16	target	target	NOUN
dti-1304	4	17	for	for	ADP
dti-1304	4	18	systemic	systemic	ADJ
dti-1304	4	19	autoimmune	autoimmune	ADJ
dti-1304	4	20	diseases	disease	NOUN
dti-1304	4	21	hideto	hideto	VERB
dti-1304	4	22	kameda	kameda	PROPN
dti-1304	4	23	,	,	PUNCT
dti-1304	4	24	miyuki	miyuki	PROPN
dti-1304	4	25	suzuki	suzuki	PROPN
dti-1304	4	26	and	and	CCONJ
dti-1304	4	27	tsutomu	tsutomu	VERB
dti-1304	4	28	takeuchi	takeuchi	PROPN
dti-1304	4	29	division	division	PROPN
dti-1304	4	30	of	of	ADP
dti-1304	4	31	rheumatology	rheumatology	NOUN
dti-1304	4	32	/	/	SYM
dti-1304	4	33	clinical	clinical	ADJ
dti-1304	4	34	immunology	immunology	NOUN
dti-1304	4	35	,	,	PUNCT
dti-1304	4	36	department	department	NOUN
dti-1304	4	37	of	of	ADP
dti-1304	4	38	internal	internal	ADJ
dti-1304	4	39	medicine	medicine	NOUN
dti-1304	4	40	,	,	PUNCT
dti-1304	4	41	saitama	saitama	PROPN
dti-1304	4	42	medical	medical	ADJ
dti-1304	4	43	center	center	NOUN
dti-1304	4	44	,	,	PUNCT
dti-1304	4	45	saitama	saitama	PROPN
dti-1304	4	46	medical	medical	PROPN
dti-1304	4	47	university	university	PROPN
dti-1304	4	48	,	,	PUNCT
dti-1304	4	49	kawagoe	kawagoe	ADJ
dti-1304	4	50	,	,	PUNCT
dti-1304	4	51	saitama	saitama	PROPN
dti-1304	4	52	,	,	PUNCT
dti-1304	4	53	japan	japan	PROPN
dti-1304	4	54	.	.	PUNCT
dti-1304	5	1	abstract	abstract	ADJ
dti-1304	5	2	:	:	PUNCT
dti-1304	5	3	some	some	DET
dti-1304	5	4	systemic	systemic	ADJ
dti-1304	5	5	rheumatic	rheumatic	ADJ
dti-1304	5	6	diseases	disease	NOUN
dti-1304	5	7	and	and	CCONJ
dti-1304	5	8	disorders	disorder	NOUN
dti-1304	5	9	,	,	PUNCT
dti-1304	5	10	especially	especially	ADV
dti-1304	5	11	fi	fi	NOUN
dti-1304	5	12	brotic	brotic	ADJ
dti-1304	5	13	and	and	CCONJ
dti-1304	5	14	vascular	vascular	ADJ
dti-1304	5	15	disorders	disorder	NOUN
dti-1304	5	16	,	,	PUNCT
dti-1304	5	17	are	be	AUX
dti-1304	5	18	often	often	ADV
dti-1304	5	19	refractory	refractory	ADJ
dti-1304	5	20	to	to	ADP
dti-1304	5	21	corticosteroid	corticosteroid	ADJ
dti-1304	5	22	therapy	therapy	NOUN
dti-1304	5	23	.	.	PUNCT
dti-1304	6	1	recently	recently	ADV
dti-1304	6	2	,	,	PUNCT
dti-1304	6	3	ever	ever	ADV
dti-1304	6	4	accumulating	accumulate	VERB
dti-1304	6	5	evidence	evidence	NOUN
dti-1304	6	6	suggests	suggest	VERB
dti-1304	6	7	that	that	SCONJ
dti-1304	6	8	platelet	platelet	NOUN
dti-1304	6	9	-	-	PUNCT
dti-1304	6	10	derived	derive	VERB
dti-1304	6	11	growth	growth	NOUN
dti-1304	6	12	factor	factor	NOUN
dti-1304	6	13	(	(	PUNCT
dti-1304	6	14	pdgf	pdgf	NOUN
dti-1304	6	15	)	)	PUNCT
dti-1304	6	16	is	be	AUX
dti-1304	6	17	involved	involve	VERB
dti-1304	6	18	in	in	ADP
dti-1304	6	19	those	those	DET
dti-1304	6	20	refractory	refractory	NOUN
dti-1304	6	21	diseases	disease	NOUN
dti-1304	6	22	.	.	PUNCT
dti-1304	7	1	imatinib	imatinib	NOUN
dti-1304	7	2	mesylate	mesylate	VERB
dti-1304	7	3	inhibits	inhibit	VERB
dti-1304	7	4	the	the	DET
dti-1304	7	5	activation	activation	NOUN
dti-1304	7	6	of	of	ADP
dti-1304	7	7	pdgf	pdgf	ADJ
dti-1304	7	8	receptor	receptor	NOUN
dti-1304	7	9	as	as	ADV
dti-1304	7	10	well	well	ADV
dti-1304	7	11	as	as	ADP
dti-1304	7	12	c	c	NOUN
dti-1304	7	13	-	-	PUNCT
dti-1304	7	14	abl	abl	PROPN
dti-1304	7	15	,	,	PUNCT
dti-1304	7	16	bcr	bcr	PROPN
dti-1304	7	17	-	-	ADJ
dti-1304	7	18	abl	abl	PROPN
dti-1304	7	19	and	and	CCONJ
dti-1304	7	20	c	c	NOUN
dti-1304	7	21	-	-	PUNCT
dti-1304	7	22	kit	kit	ADJ
dti-1304	7	23	tyrosine	tyrosine	NOUN
dti-1304	7	24	kinases	kinase	NOUN
dti-1304	7	25	.	.	PUNCT
dti-1304	8	1	it	it	PRON
dti-1304	8	2	has	have	AUX
dti-1304	8	3	therefore	therefore	ADV
dti-1304	8	4	been	be	AUX
dti-1304	8	5	widely	widely	ADV
dti-1304	8	6	used	use	VERB
dti-1304	8	7	for	for	ADP
dti-1304	8	8	the	the	DET
dti-1304	8	9	treatment	treatment	NOUN
dti-1304	8	10	of	of	ADP
dti-1304	8	11	chronic	chronic	ADJ
dti-1304	8	12	myeloid	myeloid	NOUN
dti-1304	8	13	leukemia	leukemia	NOUN
dti-1304	8	14	and	and	CCONJ
dti-1304	8	15	gastrointestinal	gastrointestinal	ADJ
dti-1304	8	16	stromal	stromal	ADJ
dti-1304	8	17	tumors	tumor	NOUN
dti-1304	8	18	.	.	PUNCT
dti-1304	9	1	imatinib	imatinib	NOUN
dti-1304	9	2	effectively	effectively	ADV
dti-1304	9	3	suppresses	suppress	VERB
dti-1304	9	4	the	the	DET
dti-1304	9	5	activation	activation	NOUN
dti-1304	9	6	and	and	CCONJ
dti-1304	9	7	proliferation	proliferation	NOUN
dti-1304	9	8	of	of	ADP
dti-1304	9	9	fi	fi	NOUN
dti-1304	9	10	broblasts	broblast	NOUN
dti-1304	9	11	,	,	PUNCT
dti-1304	9	12	mesangial	mesangial	ADJ
dti-1304	9	13	cells	cell	NOUN
dti-1304	9	14	and	and	CCONJ
dti-1304	9	15	smooth	smooth	ADJ
dti-1304	9	16	muscle	muscle	NOUN
dti-1304	9	17	cells	cell	NOUN
dti-1304	9	18	both	both	CCONJ
dti-1304	9	19	in	in	ADP
dti-1304	9	20	vitro	vitro	X
dti-1304	9	21	and	and	CCONJ
dti-1304	9	22	in	in	ADP
dti-1304	9	23	vivo	vivo	NOUN
dti-1304	9	24	.	.	PUNCT
dti-1304	10	1	additionally	additionally	ADV
dti-1304	10	2	,	,	PUNCT
dti-1304	10	3	it	it	PRON
dti-1304	10	4	has	have	AUX
dti-1304	10	5	recently	recently	ADV
dti-1304	10	6	been	be	AUX
dti-1304	10	7	reported	report	VERB
dti-1304	10	8	that	that	SCONJ
dti-1304	10	9	some	some	DET
dti-1304	10	10	patients	patient	NOUN
dti-1304	10	11	with	with	ADP
dti-1304	10	12	rheumatoid	rheumatoid	NOUN
dti-1304	10	13	arthritis	arthritis	NOUN
dti-1304	10	14	or	or	CCONJ
dti-1304	10	15	idiopathic	idiopathic	ADJ
dti-1304	10	16	pulmonary	pulmonary	ADJ
dti-1304	10	17	arterial	arterial	NOUN
dti-1304	10	18	hypertension	hypertension	NOUN
dti-1304	10	19	demonstrated	demonstrate	VERB
dti-1304	10	20	a	a	DET
dti-1304	10	21	good	good	ADJ
dti-1304	10	22	clinical	clinical	ADJ
dti-1304	10	23	response	response	NOUN
dti-1304	10	24	to	to	ADP
dti-1304	10	25	imatinib	imatinib	NOUN
dti-1304	10	26	therapy	therapy	NOUN
dti-1304	10	27	.	.	PUNCT
dti-1304	11	1	imatinib	imatinib	NOUN
dti-1304	11	2	may	may	AUX
dti-1304	11	3	therefore	therefore	ADV
dti-1304	11	4	overcome	overcome	VERB
dti-1304	11	5	the	the	DET
dti-1304	11	6	limitations	limitation	NOUN
dti-1304	11	7	of	of	ADP
dti-1304	11	8	current	current	ADJ
dti-1304	11	9	therapeutic	therapeutic	ADJ
dti-1304	11	10	strategy	strategy	NOUN
dti-1304	11	11	with	with	ADP
dti-1304	11	12	corticosteroids	corticosteroid	NOUN
dti-1304	11	13	and	and	CCONJ
dti-1304	11	14	immunosuppressive	immunosuppressive	ADJ
dti-1304	11	15	agents	agent	NOUN
dti-1304	11	16	for	for	ADP
dti-1304	11	17	refractory	refractory	NOUN
dti-1304	11	18	diseases	disease	NOUN
dti-1304	11	19	,	,	PUNCT
dti-1304	11	20	such	such	ADJ
dti-1304	11	21	as	as	ADP
dti-1304	11	22	systemic	systemic	ADJ
dti-1304	11	23	sclerosis	sclerosis	NOUN
dti-1304	11	24	and	and	CCONJ
dti-1304	11	25	interstitial	interstitial	ADJ
dti-1304	11	26	lung	lung	NOUN
dti-1304	11	27	diseases	disease	NOUN
dti-1304	11	28	,	,	PUNCT
dti-1304	11	29	without	without	ADP
dti-1304	11	30	clinical	clinical	ADJ
dti-1304	11	31	intolerability	intolerability	NOUN
dti-1304	11	32	.	.	PUNCT
dti-1304	12	1	keywords	keyword	NOUN
dti-1304	12	2	:	:	PUNCT
dti-1304	12	3	imatinib	imatinib	NOUN
dti-1304	12	4	mesylate	mesylate	VERB
dti-1304	12	5	,	,	PUNCT
dti-1304	12	6	rheumatoid	rheumatoid	NOUN
dti-1304	12	7	arthritis	arthritis	NOUN
dti-1304	12	8	,	,	PUNCT
dti-1304	12	9	fi	fi	NOUN
dti-1304	12	10	broblast	broblast	ADJ
dti-1304	12	11	,	,	PUNCT
dti-1304	12	12	rheumatic	rheumatic	ADJ
dti-1304	12	13	diseases	disease	NOUN
dti-1304	12	14	,	,	PUNCT
dti-1304	12	15	interstitial	interstitial	ADJ
dti-1304	12	16	lung	lung	NOUN
dti-1304	12	17	disease	disease	NOUN
dti-1304	12	18	introduction	introduction	NOUN
dti-1304	12	19	the	the	DET
dti-1304	12	20	developmental	developmental	ADJ
dti-1304	12	21	process	process	NOUN
dti-1304	12	22	of	of	ADP
dti-1304	12	23	systemic	systemic	ADJ
dti-1304	12	24	autoimmune	autoimmune	ADJ
dti-1304	12	25	diseases	disease	NOUN
dti-1304	12	26	has	have	AUX
dti-1304	12	27	been	be	AUX
dti-1304	12	28	an	an	DET
dti-1304	12	29	unsolved	unsolved	ADJ
dti-1304	12	30	mystery	mystery	NOUN
dti-1304	12	31	for	for	ADP
dti-1304	12	32	decades	decade	NOUN
dti-1304	12	33	.	.	PUNCT
dti-1304	13	1	despite	despite	SCONJ
dti-1304	13	2	the	the	DET
dti-1304	13	3	identifi	identifi	PROPN
dti-1304	13	4	cation	cation	NOUN
dti-1304	13	5	of	of	ADP
dti-1304	13	6	autoreactive	autoreactive	ADJ
dti-1304	13	7	t	t	NOUN
dti-1304	13	8	lymphocytes	lymphocyte	NOUN
dti-1304	13	9	or	or	CCONJ
dti-1304	13	10	autoantibodies	autoantibody	NOUN
dti-1304	13	11	,	,	PUNCT
dti-1304	13	12	both	both	PRON
dti-1304	13	13	of	of	ADP
dti-1304	13	14	which	which	PRON
dti-1304	13	15	may	may	AUX
dti-1304	13	16	participate	participate	VERB
dti-1304	13	17	in	in	ADP
dti-1304	13	18	the	the	DET
dti-1304	13	19	pathogenesis	pathogenesis	NOUN
dti-1304	13	20	of	of	ADP
dti-1304	13	21	the	the	DET
dti-1304	13	22	diseases	disease	NOUN
dti-1304	13	23	,	,	PUNCT
dti-1304	13	24	any	any	DET
dti-1304	13	25	precise	precise	ADJ
dti-1304	13	26	insight	insight	NOUN
dti-1304	13	27	into	into	ADP
dti-1304	13	28	“	"	PUNCT
dti-1304	13	29	immunodistortion	immunodistortion	NOUN
dti-1304	13	30	”	"	PUNCT
dti-1304	13	31	present	present	NOUN
dti-1304	13	32	in	in	ADP
dti-1304	13	33	each	each	DET
dti-1304	13	34	patient	patient	NOUN
dti-1304	13	35	is	be	AUX
dti-1304	13	36	lacking	lack	VERB
dti-1304	13	37	.	.	PUNCT
dti-1304	14	1	therefore	therefore	ADV
dti-1304	14	2	,	,	PUNCT
dti-1304	14	3	overall	overall	ADJ
dti-1304	14	4	immunosuppression	immunosuppression	NOUN
dti-1304	14	5	,	,	PUNCT
dti-1304	14	6	instead	instead	ADV
dti-1304	14	7	of	of	ADP
dti-1304	14	8	a	a	DET
dti-1304	14	9	specifi	specifi	PROPN
dti-1304	14	10	c	c	PROPN
dti-1304	14	11	correction	correction	NOUN
dti-1304	14	12	of	of	ADP
dti-1304	14	13	“	"	PUNCT
dti-1304	14	14	immunodistortion	immunodistortion	NOUN
dti-1304	14	15	,	,	PUNCT
dti-1304	14	16	”	"	PUNCT
dti-1304	14	17	has	have	AUX
dti-1304	14	18	been	be	AUX
dti-1304	14	19	a	a	DET
dti-1304	14	20	common	common	ADJ
dti-1304	14	21	choice	choice	NOUN
dti-1304	14	22	in	in	ADP
dti-1304	14	23	clinical	clinical	ADJ
dti-1304	14	24	practice	practice	NOUN
dti-1304	14	25	.	.	PUNCT
dti-1304	15	1	corticosteroids	corticosteroid	NOUN
dti-1304	15	2	and	and	CCONJ
dti-1304	15	3	immunosuppressive	immunosuppressive	ADJ
dti-1304	15	4	agents	agent	NOUN
dti-1304	15	5	have	have	AUX
dti-1304	15	6	been	be	AUX
dti-1304	15	7	the	the	DET
dti-1304	15	8	mainstay	mainstay	NOUN
dti-1304	15	9	of	of	ADP
dti-1304	15	10	the	the	DET
dti-1304	15	11	therapeutic	therapeutic	ADJ
dti-1304	15	12	strategy	strategy	NOUN
dti-1304	15	13	of	of	ADP
dti-1304	15	14	systemic	systemic	ADJ
dti-1304	15	15	rheumatic	rheumatic	ADJ
dti-1304	15	16	diseases	disease	NOUN
dti-1304	15	17	.	.	PUNCT
dti-1304	16	1	however	however	ADV
dti-1304	16	2	,	,	PUNCT
dti-1304	16	3	the	the	DET
dti-1304	16	4	presence	presence	NOUN
dti-1304	16	5	of	of	ADP
dti-1304	16	6	refractory	refractory	NOUN
dti-1304	16	7	diseases	disease	NOUN
dti-1304	16	8	/	/	SYM
dti-1304	16	9	patients	patient	NOUN
dti-1304	16	10	to	to	ADP
dti-1304	16	11	such	such	ADJ
dti-1304	16	12	approaches	approach	NOUN
dti-1304	16	13	,	,	PUNCT
dti-1304	16	14	and	and	CCONJ
dti-1304	16	15	various	various	ADJ
dti-1304	16	16	adverse	adverse	ADJ
dti-1304	16	17	effects	effect	NOUN
dti-1304	16	18	such	such	ADJ
dti-1304	16	19	as	as	ADP
dti-1304	16	20	increased	increase	VERB
dti-1304	16	21	risk	risk	NOUN
dti-1304	16	22	of	of	ADP
dti-1304	16	23	severe	severe	ADJ
dti-1304	16	24	infections	infection	NOUN
dti-1304	16	25	,	,	PUNCT
dti-1304	16	26	limits	limit	VERB
dti-1304	16	27	their	their	PRON
dti-1304	16	28	effi	effi	PROPN
dti-1304	16	29	cacy	cacy	NOUN
dti-1304	16	30	.	.	PUNCT
dti-1304	17	1	recent	recent	ADJ
dti-1304	17	2	progress	progress	NOUN
dti-1304	17	3	in	in	ADP
dti-1304	17	4	our	our	PRON
dti-1304	17	5	general	general	ADJ
dti-1304	17	6	understanding	understanding	NOUN
dti-1304	17	7	of	of	ADP
dti-1304	17	8	molecular	molecular	ADJ
dti-1304	17	9	pathophysiology	pathophysiology	NOUN
dti-1304	17	10	of	of	ADP
dti-1304	17	11	diseases	disease	NOUN
dti-1304	17	12	possibly	possibly	ADV
dti-1304	17	13	downstream	downstream	ADV
dti-1304	17	14	of	of	ADP
dti-1304	17	15	the	the	DET
dti-1304	17	16	“	"	PUNCT
dti-1304	17	17	immunodistortion	immunodistortion	NOUN
dti-1304	17	18	”	"	PUNCT
dti-1304	17	19	has	have	AUX
dti-1304	17	20	led	lead	VERB
dti-1304	17	21	us	we	PRON
dti-1304	17	22	to	to	PART
dti-1304	17	23	develop	develop	VERB
dti-1304	17	24	molecular	molecular	ADJ
dti-1304	17	25	targeted	target	VERB
dti-1304	17	26	therapies	therapy	NOUN
dti-1304	17	27	in	in	ADP
dti-1304	17	28	which	which	PRON
dti-1304	17	29	the	the	DET
dti-1304	17	30	function	function	NOUN
dti-1304	17	31	of	of	ADP
dti-1304	17	32	the	the	DET
dti-1304	17	33	key	key	ADJ
dti-1304	17	34	molecule(s	molecule(s	NOUN
dti-1304	17	35	)	)	PUNCT
dti-1304	17	36	of	of	ADP
dti-1304	17	37	the	the	DET
dti-1304	17	38	diseases	disease	NOUN
dti-1304	17	39	is	be	AUX
dti-1304	17	40	manipulated	manipulate	VERB
dti-1304	17	41	in	in	ADP
dti-1304	17	42	order	order	NOUN
dti-1304	17	43	to	to	PART
dti-1304	17	44	control	control	VERB
dti-1304	17	45	disease	disease	NOUN
dti-1304	17	46	activity	activity	NOUN
dti-1304	17	47	.	.	PUNCT
dti-1304	18	1	we	we	PRON
dti-1304	18	2	have	have	VERB
dti-1304	18	3	then	then	ADV
dti-1304	18	4	an	an	DET
dti-1304	18	5	excellent	excellent	ADJ
dti-1304	18	6	safety	safety	NOUN
dti-1304	18	7	profi	profi	PROPN
dti-1304	18	8	le	le	X
dti-1304	18	9	in	in	ADP
dti-1304	18	10	terms	term	NOUN
dti-1304	18	11	of	of	ADP
dti-1304	18	12	an	an	DET
dti-1304	18	13	eventual	eventual	ADJ
dti-1304	18	14	lack	lack	NOUN
dti-1304	18	15	of	of	ADP
dti-1304	18	16	lethal	lethal	ADJ
dti-1304	18	17	dosage	dosage	NOUN
dti-1304	18	18	enabled	enable	VERB
dti-1304	18	19	most	most	ADJ
dti-1304	18	20	of	of	ADP
dti-1304	18	21	the	the	DET
dti-1304	18	22	biologic	biologic	ADJ
dti-1304	18	23	response	response	NOUN
dti-1304	18	24	modifi	modifi	NOUN
dti-1304	18	25	ers	er	NOUN
dti-1304	18	26	(	(	PUNCT
dti-1304	18	27	biologics	biologic	NOUN
dti-1304	18	28	)	)	PUNCT
dti-1304	18	29	that	that	PRON
dti-1304	18	30	can	can	AUX
dti-1304	18	31	be	be	AUX
dti-1304	18	32	applied	apply	VERB
dti-1304	18	33	at	at	ADP
dti-1304	18	34	the	the	DET
dti-1304	18	35	dosage	dosage	NOUN
dti-1304	18	36	with	with	ADP
dti-1304	18	37	which	which	PRON
dti-1304	18	38	they	they	PRON
dti-1304	18	39	suffi	suffi	VERB
dti-1304	18	40	ciently	ciently	ADV
dti-1304	18	41	inhibit	inhibit	VERB
dti-1304	18	42	the	the	DET
dti-1304	18	43	function	function	NOUN
dti-1304	18	44	of	of	ADP
dti-1304	18	45	the	the	DET
dti-1304	18	46	targeted	target	VERB
dti-1304	18	47	molecule	molecule	NOUN
dti-1304	18	48	.	.	PUNCT
dti-1304	19	1	for	for	ADP
dti-1304	19	2	example	example	NOUN
dti-1304	19	3	,	,	PUNCT
dti-1304	19	4	tumor	tumor	NOUN
dti-1304	19	5	necrosis	necrosis	NOUN
dti-1304	19	6	factor	factor	NOUN
dti-1304	19	7	α	α	PROPN
dti-1304	19	8	(	(	PUNCT
dti-1304	19	9	tnfα	tnfα	NOUN
dti-1304	19	10	)	)	PUNCT
dti-1304	19	11	inhibitors	inhibitor	NOUN
dti-1304	19	12	dramatically	dramatically	ADV
dti-1304	19	13	improved	improve	VERB
dti-1304	19	14	the	the	DET
dti-1304	19	15	outcome	outcome	NOUN
dti-1304	19	16	of	of	ADP
dti-1304	19	17	patients	patient	NOUN
dti-1304	19	18	with	with	ADP
dti-1304	19	19	rheumatic	rheumatic	ADJ
dti-1304	19	20	diseases	disease	NOUN
dti-1304	19	21	such	such	ADJ
dti-1304	19	22	as	as	ADP
dti-1304	19	23	rheumatoid	rheumatoid	NOUN
dti-1304	19	24	arthritis	arthritis	NOUN
dti-1304	19	25	(	(	PUNCT
dti-1304	19	26	ra	ra	NOUN
dti-1304	19	27	)	)	PUNCT
dti-1304	19	28	and	and	CCONJ
dti-1304	19	29	seronegative	seronegative	ADJ
dti-1304	19	30	spondyloarthropathies	spondyloarthropathie	NOUN
dti-1304	19	31	[	[	X
dti-1304	19	32	takeuchi	takeuchi	NOUN
dti-1304	19	33	,	,	PUNCT
dti-1304	19	34	2005	2005	NUM
dti-1304	19	35	]	]	PUNCT
dti-1304	19	36	.	.	PUNCT
dti-1304	20	1	those	those	DET
dti-1304	20	2	agents	agent	NOUN
dti-1304	20	3	include	include	VERB
dti-1304	20	4	a	a	DET
dti-1304	20	5	chimeric	chimeric	ADJ
dti-1304	20	6	antitnfα	antitnfα	NOUN
dti-1304	20	7	monoclonal	monoclonal	NOUN
dti-1304	20	8	antibody	antibody	NOUN
dti-1304	20	9	(	(	PUNCT
dti-1304	20	10	infl	infl	PROPN
dti-1304	20	11	iximab	iximab	PROPN
dti-1304	20	12	)	)	PUNCT
dti-1304	20	13	,	,	PUNCT
dti-1304	20	14	a	a	DET
dti-1304	20	15	humanized	humanize	VERB
dti-1304	20	16	anti	anti	ADJ
dti-1304	20	17	-	-	ADJ
dti-1304	20	18	tnfα	tnfα	ADJ
dti-1304	20	19	monoclonal	monoclonal	NOUN
dti-1304	20	20	antibody	antibody	NOUN
dti-1304	20	21	(	(	PUNCT
dti-1304	20	22	adalimumab	adalimumab	NOUN
dti-1304	20	23	)	)	PUNCT
dti-1304	20	24	,	,	PUNCT
dti-1304	20	25	and	and	CCONJ
dti-1304	20	26	a	a	DET
dti-1304	20	27	p75	p75	ADJ
dti-1304	20	28	tnf	tnf	PROPN
dti-1304	20	29	-	-	PUNCT
dti-1304	20	30	receptor	receptor	NOUN
dti-1304	20	31	/	/	SYM
dti-1304	20	32	igg	igg	PROPN
dti-1304	20	33	-	-	PUNCT
dti-1304	20	34	fc	fc	PROPN
dti-1304	20	35	fusion	fusion	NOUN
dti-1304	20	36	protein	protein	NOUN
dti-1304	20	37	(	(	PUNCT
dti-1304	20	38	etanercept	etanercept	NOUN
dti-1304	20	39	)	)	PUNCT
dti-1304	20	40	.	.	PUNCT
dti-1304	21	1	in	in	ADP
dti-1304	21	2	addition	addition	NOUN
dti-1304	21	3	,	,	PUNCT
dti-1304	21	4	a	a	DET
dti-1304	21	5	chimeric	chimeric	ADJ
dti-1304	21	6	anti	anti	ADJ
dti-1304	21	7	-	-	ADJ
dti-1304	21	8	cd20	cd20	ADJ
dti-1304	21	9	monoclonal	monoclonal	NOUN
dti-1304	21	10	antibody	antibody	NOUN
dti-1304	21	11	(	(	PUNCT
dti-1304	21	12	rituximab	rituximab	NOUN
dti-1304	21	13	)	)	PUNCT
dti-1304	21	14	,	,	PUNCT
dti-1304	21	15	anti	anti	ADJ
dti-1304	21	16	-	-	ADJ
dti-1304	21	17	interleukin-6	interleukin-6	NUM
dti-1304	21	18	receptor	receptor	NOUN
dti-1304	21	19	monoclonal	monoclonal	NOUN
dti-1304	21	20	antibody	antibody	NOUN
dti-1304	21	21	(	(	PUNCT
dti-1304	21	22	tocilizumab	tocilizumab	NOUN
dti-1304	21	23	)	)	PUNCT
dti-1304	21	24	,	,	PUNCT
dti-1304	21	25	and	and	CCONJ
dti-1304	21	26	cytotoxic	cytotoxic	ADJ
dti-1304	21	27	t	t	NOUN
dti-1304	21	28	-	-	PUNCT
dti-1304	21	29	lymphocyte	lymphocyte	NOUN
dti-1304	21	30	antigen	antigen	NOUN
dti-1304	21	31	4	4	NUM
dti-1304	21	32	(	(	PUNCT
dti-1304	21	33	ctla-4	ctla-4	NUM
dti-1304	21	34	;	;	PUNCT
dti-1304	21	35	cd152)/igg	cd152)/igg	PROPN
dti-1304	21	36	-	-	PUNCT
dti-1304	21	37	fc	fc	PROPN
dti-1304	21	38	fusion	fusion	NOUN
dti-1304	21	39	protein	protein	NOUN
dti-1304	21	40	(	(	PUNCT
dti-1304	21	41	abatacept	abatacept	ADJ
dti-1304	21	42	)	)	PUNCT
dti-1304	21	43	have	have	AUX
dti-1304	21	44	been	be	AUX
dti-1304	21	45	also	also	ADV
dti-1304	21	46	successful	successful	ADJ
dti-1304	21	47	in	in	ADP
dti-1304	21	48	ra	ra	PROPN
dti-1304	21	49	.	.	PUNCT
dti-1304	22	1	on	on	ADP
dti-1304	22	2	the	the	DET
dti-1304	22	3	other	other	ADJ
dti-1304	22	4	hand	hand	NOUN
dti-1304	22	5	,	,	PUNCT
dti-1304	22	6	low	low	ADJ
dti-1304	22	7	molecular	molecular	ADJ
dti-1304	22	8	weight	weight	NOUN
dti-1304	22	9	chemical	chemical	NOUN
dti-1304	22	10	agents	agent	NOUN
dti-1304	22	11	developed	develop	VERB
dti-1304	22	12	as	as	ADP
dti-1304	22	13	molecular	molecular	ADJ
dti-1304	22	14	targeted	target	VERB
dti-1304	22	15	therapies	therapy	NOUN
dti-1304	22	16	do	do	AUX
dti-1304	22	17	have	have	VERB
dti-1304	22	18	some	some	DET
dti-1304	22	19	drawbacks	drawback	NOUN
dti-1304	22	20	compared	compare	VERB
dti-1304	22	21	to	to	ADP
dti-1304	22	22	biologics	biologic	NOUN
dti-1304	22	23	in	in	ADP
dti-1304	22	24	terms	term	NOUN
dti-1304	22	25	of	of	ADP
dti-1304	22	26	selectivity	selectivity	NOUN
dti-1304	22	27	and	and	CCONJ
dti-1304	22	28	limitations	limitation	NOUN
dti-1304	22	29	in	in	ADP
dti-1304	22	30	dosage	dosage	NOUN
dti-1304	22	31	.	.	PUNCT
dti-1304	23	1	nonetheless	nonetheless	ADV
dti-1304	23	2	,	,	PUNCT
dti-1304	23	3	their	their	PRON
dti-1304	23	4	intracellular	intracellular	ADJ
dti-1304	23	5	activity	activity	NOUN
dti-1304	23	6	which	which	PRON
dti-1304	23	7	large	large	ADJ
dti-1304	23	8	-	-	PUNCT
dti-1304	23	9	molecular	molecular	ADJ
dti-1304	23	10	agents	agent	NOUN
dti-1304	23	11	such	such	ADJ
dti-1304	23	12	as	as	ADP
dti-1304	23	13	biologics	biologic	NOUN
dti-1304	23	14	do	do	AUX
dti-1304	23	15	not	not	PART
dti-1304	23	16	possess	possess	VERB
dti-1304	23	17	,	,	PUNCT
dti-1304	23	18	although	although	SCONJ
dti-1304	23	19	slightly	slightly	ADV
dti-1304	23	20	less	less	ADV
dti-1304	23	21	selective	selective	ADJ
dti-1304	23	22	,	,	PUNCT
dti-1304	23	23	is	be	AUX
dti-1304	23	24	still	still	ADV
dti-1304	23	25	indispensable	indispensable	ADJ
dti-1304	23	26	in	in	ADP
dti-1304	23	27	the	the	DET
dti-1304	23	28	treatment	treatment	NOUN
dti-1304	23	29	of	of	ADP
dti-1304	23	30	diseases	disease	NOUN
dti-1304	23	31	in	in	ADP
dti-1304	23	32	which	which	PRON
dti-1304	23	33	various	various	ADJ
dti-1304	23	34	cytoplasmic	cytoplasmic	ADJ
dti-1304	23	35	/	/	SYM
dti-1304	23	36	nuclear	nuclear	ADJ
dti-1304	23	37	molecules	molecule	NOUN
dti-1304	23	38	play	play	VERB
dti-1304	23	39	important	important	ADJ
dti-1304	23	40	roles	role	NOUN
dti-1304	23	41	.	.	PUNCT
dti-1304	24	1	in	in	ADP
dti-1304	24	2	diseases	disease	NOUN
dti-1304	24	3	refractory	refractory	NOUN
dti-1304	24	4	to	to	ADP
dti-1304	24	5	glucocorticoids	glucocorticoid	NOUN
dti-1304	24	6	and	and	CCONJ
dti-1304	24	7	conventional	conventional	ADJ
dti-1304	24	8	immunosuppressants	immunosuppressant	NOUN
dti-1304	24	9	such	such	ADJ
dti-1304	24	10	as	as	ADP
dti-1304	24	11	cyclophosphamide	cyclophosphamide	NOUN
dti-1304	24	12	—	—	PUNCT
dti-1304	24	13	both	both	PRON
dti-1304	24	14	of	of	ADP
dti-1304	24	15	which	which	PRON
dti-1304	24	16	are	be	AUX
dti-1304	24	17	chiefl	chiefl	VERB
dti-1304	24	18	y	y	PRON
dti-1304	24	19	targeted	target	VERB
dti-1304	24	20	to	to	ADP
dti-1304	24	21	leukocytes	leukocyte	NOUN
dti-1304	24	22	—	—	PUNCT
dti-1304	24	23	,	,	PUNCT
dti-1304	24	24	cells	cell	NOUN
dti-1304	24	25	of	of	ADP
dti-1304	24	26	mesenchymal	mesenchymal	ADJ
dti-1304	24	27	origin	origin	NOUN
dti-1304	24	28	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1304	24	29	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1304	24	30	240	240	NUM
dti-1304	24	31	kameda	kameda	NOUN
dti-1304	24	32	et	et	PROPN
dti-1304	24	33	al	al	PROPN
dti-1304	24	34	drug	drug	PROPN
dti-1304	24	35	target	target	NOUN
dti-1304	24	36	insights	insight	NOUN
dti-1304	24	37	2007:2	2007:2	NUM
dti-1304	24	38	such	such	ADJ
dti-1304	24	39	as	as	ADP
dti-1304	24	40	fi	fi	NOUN
dti-1304	24	41	broblast	broblast	ADJ
dti-1304	24	42	and	and	CCONJ
dti-1304	24	43	vascular	vascular	ADJ
dti-1304	24	44	cells	cell	NOUN
dti-1304	24	45	play	play	VERB
dti-1304	24	46	a	a	DET
dti-1304	24	47	pivotal	pivotal	ADJ
dti-1304	24	48	role	role	NOUN
dti-1304	24	49	.	.	PUNCT
dti-1304	25	1	novel	novel	ADJ
dti-1304	25	2	molecular	molecular	ADJ
dti-1304	25	3	targeted	target	VERB
dti-1304	25	4	therapies	therapy	NOUN
dti-1304	25	5	should	should	AUX
dti-1304	25	6	therefore	therefore	ADV
dti-1304	25	7	include	include	VERB
dti-1304	25	8	growth	growth	NOUN
dti-1304	25	9	factors	factor	NOUN
dti-1304	25	10	participating	participate	VERB
dti-1304	25	11	in	in	ADP
dti-1304	25	12	the	the	DET
dti-1304	25	13	remodeling	remodeling	NOUN
dti-1304	25	14	of	of	ADP
dti-1304	25	15	mesenchymal	mesenchymal	ADJ
dti-1304	25	16	tissues	tissue	NOUN
dti-1304	25	17	.	.	PUNCT
dti-1304	26	1	among	among	ADP
dti-1304	26	2	various	various	ADJ
dti-1304	26	3	growth	growth	NOUN
dti-1304	26	4	factors	factor	NOUN
dti-1304	26	5	,	,	PUNCT
dti-1304	26	6	platelet	platelet	NOUN
dti-1304	26	7	-	-	PUNCT
dti-1304	26	8	derived	derive	VERB
dti-1304	26	9	growth	growth	NOUN
dti-1304	26	10	factor	factor	NOUN
dti-1304	26	11	(	(	PUNCT
dti-1304	26	12	pdgf	pdgf	NOUN
dti-1304	26	13	)	)	PUNCT
dti-1304	26	14	is	be	AUX
dti-1304	26	15	an	an	DET
dti-1304	26	16	excellent	excellent	ADJ
dti-1304	26	17	candidate	candidate	NOUN
dti-1304	26	18	due	due	ADP
dti-1304	26	19	to	to	ADP
dti-1304	26	20	its	its	PRON
dti-1304	26	21	multipotent	multipotent	NOUN
dti-1304	26	22	roles	role	NOUN
dti-1304	26	23	in	in	ADP
dti-1304	26	24	many	many	ADJ
dti-1304	26	25	rheumatic	rheumatic	ADJ
dti-1304	26	26	diseases	disease	NOUN
dti-1304	26	27	[	[	X
dti-1304	26	28	östman	östman	NOUN
dti-1304	26	29	and	and	CCONJ
dti-1304	26	30	heldin	heldin	NOUN
dti-1304	26	31	,	,	PUNCT
dti-1304	26	32	2001	2001	NUM
dti-1304	26	33	;	;	PUNCT
dti-1304	26	34	paniagua	paniagua	NOUN
dti-1304	26	35	and	and	CCONJ
dti-1304	26	36	robinson	robinson	PROPN
dti-1304	26	37	,	,	PUNCT
dti-1304	26	38	2007	2007	NUM
dti-1304	26	39	]	]	PUNCT
dti-1304	26	40	.	.	PUNCT
dti-1304	27	1	it	it	PRON
dti-1304	27	2	can	can	AUX
dti-1304	27	3	be	be	AUX
dti-1304	27	4	interfered	interfere	VERB
dti-1304	27	5	with	with	ADP
dti-1304	27	6	monoclonal	monoclonal	NOUN
dti-1304	27	7	antibodies	antibody	NOUN
dti-1304	27	8	against	against	ADP
dti-1304	27	9	pdgf	pdgf	NOUN
dti-1304	27	10	or	or	CCONJ
dti-1304	27	11	its	its	PRON
dti-1304	27	12	receptor	receptor	NOUN
dti-1304	27	13	(	(	PUNCT
dti-1304	27	14	pdgf	pdgf	NOUN
dti-1304	27	15	-	-	PUNCT
dti-1304	27	16	r	r	NOUN
dti-1304	27	17	)	)	PUNCT
dti-1304	27	18	.	.	PUNCT
dti-1304	28	1	another	another	DET
dti-1304	28	2	approach	approach	NOUN
dti-1304	28	3	in	in	ADP
dti-1304	28	4	inhibiting	inhibit	VERB
dti-1304	28	5	pdgf	pdgf	NOUN
dti-1304	28	6	signaling	signal	VERB
dti-1304	28	7	is	be	AUX
dti-1304	28	8	the	the	DET
dti-1304	28	9	application	application	NOUN
dti-1304	28	10	of	of	ADP
dti-1304	28	11	tyrosine	tyrosine	NOUN
dti-1304	28	12	kinase	kinase	PROPN
dti-1304	28	13	inhibitors	inhibitor	NOUN
dti-1304	28	14	of	of	ADP
dti-1304	28	15	pdgf	pdgf	NOUN
dti-1304	28	16	-	-	PUNCT
dti-1304	28	17	r.	r.	NOUN
dti-1304	28	18	in	in	ADP
dti-1304	28	19	contrast	contrast	NOUN
dti-1304	28	20	to	to	ADP
dti-1304	28	21	non	non	ADJ
dti-1304	28	22	-	-	ADJ
dti-1304	28	23	selective	selective	ADJ
dti-1304	28	24	tyrosine	tyrosine	NOUN
dti-1304	28	25	kinase	kinase	PROPN
dti-1304	28	26	inhibitors	inhibitor	NOUN
dti-1304	28	27	such	such	ADJ
dti-1304	28	28	as	as	ADP
dti-1304	28	29	genestein	genestein	ADJ
dti-1304	28	30	,	,	PUNCT
dti-1304	28	31	imatinib	imatinib	NOUN
dti-1304	28	32	mesylate	mesylate	NOUN
dti-1304	28	33	(	(	PUNCT
dti-1304	28	34	sti571	sti571	NOUN
dti-1304	28	35	;	;	PUNCT
dti-1304	28	36	gleevec	gleevec	PROPN
dti-1304	28	37	®	®	PROPN
dti-1304	28	38	or	or	CCONJ
dti-1304	28	39	glivec	glivec	PROPN
dti-1304	28	40	®	®	PROPN
dti-1304	28	41	)	)	PUNCT
dti-1304	28	42	has	have	AUX
dti-1304	28	43	been	be	AUX
dti-1304	28	44	widely	widely	ADV
dti-1304	28	45	used	use	VERB
dti-1304	28	46	for	for	ADP
dti-1304	28	47	the	the	DET
dti-1304	28	48	treatment	treatment	NOUN
dti-1304	28	49	of	of	ADP
dti-1304	28	50	chronic	chronic	ADJ
dti-1304	28	51	myeloid	myeloid	NOUN
dti-1304	28	52	leukemia	leukemia	NOUN
dti-1304	28	53	(	(	PUNCT
dti-1304	28	54	cml	cml	PROPN
dti-1304	28	55	)	)	PUNCT
dti-1304	29	1	[	[	X
dti-1304	29	2	druker	druker	NOUN
dti-1304	29	3	et	et	PROPN
dti-1304	29	4	al	al	PROPN
dti-1304	29	5	.	.	PROPN
dti-1304	29	6	2001a	2001a	NUM
dti-1304	29	7	;	;	PUNCT
dti-1304	29	8	druker	druker	NOUN
dti-1304	29	9	et	et	PROPN
dti-1304	29	10	al	al	PROPN
dti-1304	29	11	.	.	PROPN
dti-1304	29	12	2001b	2001b	NUM
dti-1304	29	13	]	]	PUNCT
dti-1304	29	14	and	and	CCONJ
dti-1304	29	15	gastrointestinal	gastrointestinal	ADJ
dti-1304	29	16	stromal	stromal	ADJ
dti-1304	29	17	tumors	tumor	NOUN
dti-1304	29	18	(	(	PUNCT
dti-1304	29	19	gist	gist	NOUN
dti-1304	29	20	)	)	PUNCT
dti-1304	30	1	[	[	X
dti-1304	30	2	demetri	demetri	PROPN
dti-1304	30	3	et	et	PROPN
dti-1304	30	4	al	al	PROPN
dti-1304	30	5	.	.	PROPN
dti-1304	30	6	2002	2002	NUM
dti-1304	30	7	]	]	PUNCT
dti-1304	30	8	.	.	PUNCT
dti-1304	31	1	therefore	therefore	ADV
dti-1304	31	2	,	,	PUNCT
dti-1304	31	3	in	in	ADP
dti-1304	31	4	order	order	NOUN
dti-1304	31	5	to	to	PART
dti-1304	31	6	speculate	speculate	VERB
dti-1304	31	7	on	on	ADP
dti-1304	31	8	the	the	DET
dti-1304	31	9	clinical	clinical	ADJ
dti-1304	31	10	importance	importance	NOUN
dti-1304	31	11	of	of	ADP
dti-1304	31	12	pdgf	pdgf	NOUN
dti-1304	31	13	-	-	PUNCT
dti-1304	31	14	targeted	target	VERB
dti-1304	31	15	therapy	therapy	NOUN
dti-1304	31	16	in	in	ADP
dti-1304	31	17	refractory	refractory	NOUN
dti-1304	31	18	diseases	disease	NOUN
dti-1304	31	19	and	and	CCONJ
dti-1304	31	20	patients	patient	NOUN
dti-1304	31	21	,	,	PUNCT
dti-1304	31	22	this	this	DET
dti-1304	31	23	review	review	NOUN
dti-1304	31	24	article	article	NOUN
dti-1304	31	25	summarizes	summarize	VERB
dti-1304	31	26	the	the	DET
dti-1304	31	27	involvement	involvement	NOUN
dti-1304	31	28	of	of	ADP
dti-1304	31	29	pdgf	pdgf	NOUN
dti-1304	31	30	in	in	ADP
dti-1304	31	31	systemic	systemic	ADJ
dti-1304	31	32	autoimmune	autoimmune	ADJ
dti-1304	31	33	diseases	disease	NOUN
dti-1304	31	34	,	,	PUNCT
dti-1304	31	35	as	as	ADV
dti-1304	31	36	well	well	ADV
dti-1304	31	37	as	as	ADP
dti-1304	31	38	preclinical	preclinical	ADJ
dti-1304	31	39	or	or	CCONJ
dti-1304	31	40	clinical	clinical	ADJ
dti-1304	31	41	results	result	NOUN
dti-1304	31	42	of	of	ADP
dti-1304	31	43	imatinib	imatinib	NOUN
dti-1304	31	44	or	or	CCONJ
dti-1304	31	45	other	other	ADJ
dti-1304	31	46	pdgf	pdgf	NOUN
dti-1304	31	47	-	-	PUNCT
dti-1304	31	48	targeted	target	VERB
dti-1304	31	49	therapies	therapy	NOUN
dti-1304	31	50	.	.	PUNCT
dti-1304	32	1	signaling	signal	VERB
dti-1304	32	2	from	from	ADP
dti-1304	32	3	pdgf	pdgf	ADJ
dti-1304	32	4	-	-	PUNCT
dti-1304	32	5	r	r	NOUN
dti-1304	32	6	and	and	CCONJ
dti-1304	32	7	its	its	PRON
dti-1304	32	8	inhibition	inhibition	NOUN
dti-1304	32	9	by	by	ADP
dti-1304	32	10	imatinib	imatinib	NOUN
dti-1304	32	11	pdgf	pdgf	NOUN
dti-1304	32	12	is	be	AUX
dti-1304	32	13	a	a	DET
dti-1304	32	14	family	family	NOUN
dti-1304	32	15	of	of	ADP
dti-1304	32	16	homoor	homoor	PROPN
dti-1304	32	17	hetero	hetero	NOUN
dti-1304	32	18	-	-	PUNCT
dti-1304	32	19	dimeric	dimeric	ADJ
dti-1304	32	20	molecules	molecule	NOUN
dti-1304	32	21	of	of	ADP
dti-1304	32	22	disulfi	disulfi	NOUN
dti-1304	32	23	de	de	X
dti-1304	32	24	-	-	ADJ
dti-1304	32	25	bonded	bond	VERB
dti-1304	32	26	polypeptide	polypeptide	ADJ
dti-1304	32	27	chains	chain	NOUN
dti-1304	32	28	with	with	ADP
dti-1304	32	29	a	a	DET
dti-1304	32	30	conserved	conserved	ADJ
dti-1304	32	31	sequence	sequence	NOUN
dti-1304	32	32	of	of	ADP
dti-1304	32	33	approximately	approximately	ADV
dti-1304	32	34	100	100	NUM
dti-1304	32	35	amino	amino	NOUN
dti-1304	32	36	acid	acid	NOUN
dti-1304	32	37	residues	residue	NOUN
dti-1304	32	38	containing	contain	VERB
dti-1304	32	39	a	a	DET
dti-1304	32	40	characteristic	characteristic	ADJ
dti-1304	32	41	motif	motif	NOUN
dti-1304	32	42	of	of	ADP
dti-1304	32	43	8	8	NUM
dti-1304	32	44	cystein	cystein	ADJ
dti-1304	32	45	residues	residue	NOUN
dti-1304	32	46	[	[	X
dti-1304	32	47	östman	östman	NOUN
dti-1304	32	48	and	and	CCONJ
dti-1304	32	49	heldin	heldin	NOUN
dti-1304	32	50	,	,	PUNCT
dti-1304	32	51	2001	2001	NUM
dti-1304	32	52	;	;	PUNCT
dti-1304	32	53	heldin	heldin	NOUN
dti-1304	32	54	and	and	CCONJ
dti-1304	32	55	westermark	westermark	NOUN
dti-1304	32	56	,	,	PUNCT
dti-1304	32	57	1999	1999	NUM
dti-1304	32	58	;	;	PUNCT
dti-1304	32	59	pietras	pietras	PROPN
dti-1304	32	60	et	et	PROPN
dti-1304	32	61	al	al	PROPN
dti-1304	32	62	.	.	PROPN
dti-1304	32	63	2003	2003	NUM
dti-1304	32	64	]	]	PUNCT
dti-1304	32	65	.	.	PUNCT
dti-1304	33	1	combinations	combination	NOUN
dti-1304	33	2	of	of	ADP
dti-1304	33	3	subunits	subunit	NOUN
dti-1304	33	4	aa	aa	PROPN
dti-1304	33	5	,	,	PUNCT
dti-1304	33	6	ab	ab	PROPN
dti-1304	33	7	,	,	PUNCT
dti-1304	33	8	bb	bb	PROPN
dti-1304	33	9	,	,	PUNCT
dti-1304	33	10	cc	cc	PROPN
dti-1304	33	11	and	and	CCONJ
dti-1304	33	12	dd	dd	PROPN
dti-1304	33	13	have	have	AUX
dti-1304	33	14	been	be	AUX
dti-1304	33	15	identifi	identifi	PROPN
dti-1304	33	16	ed	ed	NOUN
dti-1304	33	17	to	to	ADP
dti-1304	33	18	date	date	NOUN
dti-1304	33	19	.	.	PUNCT
dti-1304	34	1	pdgf	pdgf	NOUN
dti-1304	34	2	is	be	AUX
dti-1304	34	3	synthesized	synthesize	VERB
dti-1304	34	4	by	by	ADP
dti-1304	34	5	many	many	ADJ
dti-1304	34	6	cell	cell	NOUN
dti-1304	34	7	types	type	NOUN
dti-1304	34	8	such	such	ADJ
dti-1304	34	9	as	as	ADP
dti-1304	34	10	platelets	platelet	NOUN
dti-1304	34	11	,	,	PUNCT
dti-1304	34	12	endothelial	endothelial	ADJ
dti-1304	34	13	cells	cell	NOUN
dti-1304	34	14	,	,	PUNCT
dti-1304	34	15	fi	fi	NOUN
dti-1304	34	16	broblasts	broblast	NOUN
dti-1304	34	17	,	,	PUNCT
dti-1304	34	18	macrophages	macrophage	NOUN
dti-1304	34	19	,	,	PUNCT
dti-1304	34	20	and	and	CCONJ
dti-1304	34	21	vascular	vascular	ADJ
dti-1304	34	22	smooth	smooth	ADJ
dti-1304	34	23	muscle	muscle	NOUN
dti-1304	34	24	cells	cell	NOUN
dti-1304	34	25	.	.	PUNCT
dti-1304	35	1	the	the	DET
dti-1304	35	2	pdgf	pdgf	ADJ
dti-1304	35	3	-	-	PUNCT
dti-1304	35	4	rs	rs	NOUN
dti-1304	35	5	occur	occur	NOUN
dti-1304	35	6	as	as	ADP
dti-1304	35	7	α	α	PROPN
dti-1304	35	8	(	(	PUNCT
dti-1304	35	9	~170	~170	NOUN
dti-1304	35	10	kda	kda	NOUN
dti-1304	35	11	)	)	PUNCT
dti-1304	35	12	and	and	CCONJ
dti-1304	35	13	β	β	X
dti-1304	35	14	(	(	PUNCT
dti-1304	35	15	~180	~180	PROPN
dti-1304	35	16	kda	kda	NOUN
dti-1304	35	17	)	)	PUNCT
dti-1304	35	18	homodimers	homodimer	NOUN
dti-1304	35	19	or	or	CCONJ
dti-1304	35	20	heterodimers	heterodimer	NOUN
dti-1304	35	21	.	.	PUNCT
dti-1304	36	1	the	the	DET
dti-1304	36	2	receptor	receptor	NOUN
dti-1304	36	3	sequences	sequence	NOUN
dti-1304	36	4	have	have	VERB
dti-1304	36	5	5	5	NUM
dti-1304	36	6	immunoglobulin	immunoglobulin	NOUN
dti-1304	36	7	-	-	PUNCT
dti-1304	36	8	like	like	ADJ
dti-1304	36	9	domains	domain	NOUN
dti-1304	36	10	in	in	ADP
dti-1304	36	11	their	their	PRON
dti-1304	36	12	extracellular	extracellular	ADJ
dti-1304	36	13	parts	part	NOUN
dti-1304	36	14	and	and	CCONJ
dti-1304	36	15	tyrosine	tyrosine	PROPN
dti-1304	36	16	kinase	kinase	PROPN
dti-1304	36	17	domains	domain	VERB
dti-1304	36	18	intracellularly	intracellularly	ADV
dti-1304	36	19	into	into	ADP
dti-1304	36	20	which	which	PRON
dti-1304	36	21	is	be	AUX
dti-1304	36	22	inserted	insert	VERB
dti-1304	36	23	an	an	DET
dti-1304	36	24	interrupting	interrupt	VERB
dti-1304	36	25	sequence	sequence	NOUN
dti-1304	36	26	of	of	ADP
dti-1304	36	27	about	about	ADV
dti-1304	36	28	100	100	NUM
dti-1304	36	29	amino	amino	NOUN
dti-1304	36	30	acids	acid	NOUN
dti-1304	36	31	.	.	PUNCT
dti-1304	37	1	pdgf	pdgf	ADJ
dti-1304	37	2	-	-	PUNCT
dti-1304	37	3	aa	aa	NOUN
dti-1304	37	4	binds	bind	VERB
dti-1304	37	5	to	to	PART
dti-1304	37	6	pdgf	pdgf	VERB
dti-1304	37	7	-	-	PUNCT
dti-1304	37	8	rαα	rαα	NOUN
dti-1304	37	9	,	,	PUNCT
dti-1304	37	10	ab	ab	PROPN
dti-1304	37	11	and	and	CCONJ
dti-1304	37	12	cc	cc	X
dti-1304	37	13	to	to	ADP
dti-1304	37	14	αα	αα	PROPN
dti-1304	38	1	and	and	CCONJ
dti-1304	38	2	αβ	αβ	INTJ
dti-1304	38	3	,	,	PUNCT
dti-1304	38	4	bb	bb	PROPN
dti-1304	38	5	binds	bind	VERB
dti-1304	38	6	to	to	ADP
dti-1304	38	7	all	all	DET
dti-1304	38	8	3	3	NUM
dti-1304	38	9	combinations	combination	NOUN
dti-1304	38	10	of	of	ADP
dti-1304	38	11	receptors	receptor	NOUN
dti-1304	38	12	,	,	PUNCT
dti-1304	38	13	and	and	CCONJ
dti-1304	38	14	dd	dd	VERB
dti-1304	38	15	binds	bind	VERB
dti-1304	38	16	to	to	ADP
dti-1304	38	17	αβ	αβ	INTJ
dti-1304	38	18	and	and	CCONJ
dti-1304	38	19	ββ	ββ	PRON
dti-1304	39	1	[	[	X
dti-1304	39	2	pietras	pietras	PROPN
dti-1304	39	3	et	et	PROPN
dti-1304	39	4	al	al	PROPN
dti-1304	39	5	.	.	PROPN
dti-1304	39	6	2003	2003	NUM
dti-1304	39	7	]	]	PUNCT
dti-1304	39	8	.	.	PUNCT
dti-1304	40	1	the	the	DET
dti-1304	40	2	dimerization	dimerization	NOUN
dti-1304	40	3	and	and	CCONJ
dti-1304	40	4	activation	activation	NOUN
dti-1304	40	5	of	of	ADP
dti-1304	40	6	receptor	receptor	NOUN
dti-1304	40	7	tyrosine	tyrosine	NOUN
dti-1304	40	8	kinases	kinase	NOUN
dti-1304	40	9	lead	lead	VERB
dti-1304	40	10	to	to	ADP
dti-1304	40	11	cellular	cellular	ADJ
dti-1304	40	12	activation	activation	NOUN
dti-1304	40	13	of	of	ADP
dti-1304	40	14	targeted	target	VERB
dti-1304	40	15	cells	cell	NOUN
dti-1304	40	16	including	include	VERB
dti-1304	40	17	fibroblasts	fibroblast	NOUN
dti-1304	40	18	,	,	PUNCT
dti-1304	40	19	smooth	smooth	ADJ
dti-1304	40	20	muscle	muscle	NOUN
dti-1304	40	21	cells	cell	NOUN
dti-1304	40	22	and	and	CCONJ
dti-1304	40	23	mesangial	mesangial	ADJ
dti-1304	40	24	cells	cell	NOUN
dti-1304	40	25	.	.	PUNCT
dti-1304	41	1	a	a	DET
dti-1304	41	2	large	large	ADJ
dti-1304	41	3	number	number	NOUN
dti-1304	41	4	of	of	ADP
dti-1304	41	5	sh2	sh2	ADJ
dti-1304	41	6	domain	domain	NOUN
dti-1304	41	7	-	-	PUNCT
dti-1304	41	8	containing	contain	VERB
dti-1304	41	9	protein	protein	NOUN
dti-1304	41	10	kinases	kinase	NOUN
dti-1304	41	11	/	/	SYM
dti-1304	41	12	phosphatases	phosphatase	NOUN
dti-1304	41	13	and	and	CCONJ
dti-1304	41	14	adaptor	adaptor	NOUN
dti-1304	41	15	proteins	protein	NOUN
dti-1304	41	16	,	,	PUNCT
dti-1304	41	17	such	such	ADJ
dti-1304	41	18	as	as	ADP
dti-1304	41	19	phosphatidylinositol	phosphatidylinositol	NOUN
dti-1304	41	20	3	3	NUM
dti-1304	41	21	-	-	PUNCT
dti-1304	41	22	kinase	kinase	NOUN
dti-1304	41	23	(	(	PUNCT
dti-1304	41	24	pi3k	pi3k	PROPN
dti-1304	41	25	)	)	PUNCT
dti-1304	41	26	,	,	PUNCT
dti-1304	41	27	phospholipase	phospholipase	NOUN
dti-1304	41	28	cγ	cγ	NOUN
dti-1304	41	29	(	(	PUNCT
dti-1304	41	30	plcγ	plcγ	NOUN
dti-1304	41	31	)	)	PUNCT
dti-1304	41	32	,	,	PUNCT
dti-1304	41	33	sh2containing	sh2containing	ADJ
dti-1304	41	34	protein	protein	NOUN
dti-1304	41	35	tyrosine	tyrosine	NOUN
dti-1304	41	36	phosphatase	phosphatase	NOUN
dti-1304	41	37	shp-2	shp-2	NOUN
dti-1304	41	38	,	,	PUNCT
dti-1304	41	39	grb2	grb2	PROPN
dti-1304	41	40	,	,	PUNCT
dti-1304	41	41	nck	nck	NOUN
dti-1304	41	42	and	and	CCONJ
dti-1304	41	43	shc	shc	PROPN
dti-1304	41	44	,	,	PUNCT
dti-1304	41	45	link	link	NOUN
dti-1304	41	46	pdgf	pdgf	NOUN
dti-1304	41	47	-	-	PUNCT
dti-1304	41	48	r	r	NOUN
dti-1304	41	49	with	with	ADP
dti-1304	41	50	downstream	downstream	ADJ
dti-1304	41	51	signaling	signal	VERB
dti-1304	41	52	molecules	molecule	NOUN
dti-1304	41	53	and	and	CCONJ
dti-1304	41	54	lead	lead	VERB
dti-1304	41	55	to	to	ADP
dti-1304	41	56	upregulated	upregulated	ADJ
dti-1304	41	57	gene	gene	NOUN
dti-1304	41	58	expression	expression	NOUN
dti-1304	41	59	and	and	CCONJ
dti-1304	41	60	proliferation	proliferation	NOUN
dti-1304	41	61	,	,	PUNCT
dti-1304	41	62	or	or	CCONJ
dti-1304	41	63	transformation	transformation	NOUN
dti-1304	41	64	(	(	PUNCT
dti-1304	41	65	fig	fig	NOUN
dti-1304	41	66	.	.	NOUN
dti-1304	41	67	1	1	NUM
dti-1304	41	68	)	)	PUNCT
dti-1304	42	1	[	[	X
dti-1304	42	2	östman	östman	NOUN
dti-1304	42	3	and	and	CCONJ
dti-1304	42	4	heldin	heldin	NOUN
dti-1304	42	5	,	,	PUNCT
dti-1304	42	6	2001	2001	NUM
dti-1304	42	7	;	;	PUNCT
dti-1304	42	8	heldin	heldin	NOUN
dti-1304	42	9	and	and	CCONJ
dti-1304	42	10	westermark	westermark	NOUN
dti-1304	42	11	,	,	PUNCT
dti-1304	42	12	1999	1999	NUM
dti-1304	42	13	]	]	PUNCT
dti-1304	42	14	.	.	PUNCT
dti-1304	43	1	originally	originally	ADV
dti-1304	43	2	,	,	PUNCT
dti-1304	43	3	imatinib	imatinib	NOUN
dti-1304	43	4	focused	focus	VERB
dti-1304	43	5	on	on	ADP
dti-1304	43	6	attempts	attempt	NOUN
dti-1304	43	7	to	to	PART
dti-1304	43	8	inhibit	inhibit	VERB
dti-1304	43	9	pdgf	pdgf	ADJ
dti-1304	43	10	-	-	PUNCT
dti-1304	43	11	r	r	NOUN
dti-1304	43	12	kinase	kinase	NOUN
dti-1304	43	13	with	with	ADP
dti-1304	43	14	an	an	DET
dti-1304	43	15	ic50	ic50	PROPN
dti-1304	43	16	of	of	ADP
dti-1304	43	17	0.12	0.12	NUM
dti-1304	43	18	–	–	PUNCT
dti-1304	43	19	0.15	0.15	NUM
dti-1304	43	20	µm	µm	NOUN
dti-1304	43	21	.	.	PUNCT
dti-1304	44	1	however	however	ADV
dti-1304	44	2	,	,	PUNCT
dti-1304	44	3	it	it	PRON
dti-1304	44	4	was	be	AUX
dti-1304	44	5	soon	soon	ADV
dti-1304	44	6	noted	note	VERB
dti-1304	44	7	that	that	SCONJ
dti-1304	44	8	imatinib	imatinib	NOUN
dti-1304	44	9	effectively	effectively	ADV
dti-1304	44	10	inhibited	inhibit	VERB
dti-1304	44	11	c	c	X
dti-1304	44	12	-	-	PUNCT
dti-1304	44	13	abl	abl	PROPN
dti-1304	44	14	(	(	PUNCT
dti-1304	44	15	ic50	ic50	PROPN
dti-1304	44	16	0.1–0.3	0.1–0.3	PROPN
dti-1304	44	17	µm	µm	NOUN
dti-1304	44	18	)	)	PUNCT
dti-1304	44	19	,	,	PUNCT
dti-1304	44	20	bcr	bcr	PROPN
dti-1304	44	21	-	-	PROPN
dti-1304	44	22	abl	abl	PROPN
dti-1304	44	23	(	(	PUNCT
dti-1304	44	24	ic50	ic50	PROPN
dti-1304	44	25	0.25	0.25	NUM
dti-1304	44	26	µm	µm	NOUN
dti-1304	44	27	)	)	PUNCT
dti-1304	44	28	and	and	CCONJ
dti-1304	44	29	c	c	NOUN
dti-1304	44	30	-	-	PUNCT
dti-1304	44	31	kit	kit	NOUN
dti-1304	44	32	(	(	PUNCT
dti-1304	44	33	ic50	ic50	PROPN
dti-1304	44	34	�	�	PROPN
dti-1304	44	35	1	1	NUM
dti-1304	44	36	µm	µm	NOUN
dti-1304	44	37	)	)	PUNCT
dti-1304	45	1	[	[	X
dti-1304	45	2	carroll	carroll	NOUN
dti-1304	45	3	et	et	PROPN
dti-1304	45	4	al	al	PROPN
dti-1304	45	5	.	.	PROPN
dti-1304	45	6	1997	1997	NUM
dti-1304	45	7	;	;	PUNCT
dti-1304	45	8	druker	druker	NOUN
dti-1304	45	9	et	et	PROPN
dti-1304	45	10	al	al	PROPN
dti-1304	45	11	.	.	PROPN
dti-1304	45	12	1996	1996	NUM
dti-1304	45	13	;	;	PUNCT
dti-1304	45	14	capdeville	capdeville	NOUN
dti-1304	45	15	et	et	PROPN
dti-1304	45	16	al	al	PROPN
dti-1304	45	17	.	.	PROPN
dti-1304	45	18	2002	2002	NUM
dti-1304	45	19	]	]	PUNCT
dti-1304	45	20	.	.	PUNCT
dti-1304	46	1	imatinib	imatinib	NOUN
dti-1304	46	2	was	be	AUX
dti-1304	46	3	also	also	ADV
dti-1304	46	4	reported	report	VERB
dti-1304	46	5	to	to	PART
dti-1304	46	6	be	be	AUX
dti-1304	46	7	well	well	ADV
dti-1304	46	8	tolerated	tolerate	VERB
dti-1304	46	9	and	and	CCONJ
dti-1304	46	10	have	have	VERB
dti-1304	46	11	signifi	signifi	NOUN
dti-1304	46	12	ca	can	AUX
dti-1304	46	13	nt	not	PART
dti-1304	46	14	antileukemic	antileukemic	ADJ
dti-1304	46	15	activity	activity	NOUN
dti-1304	46	16	in	in	ADP
dti-1304	46	17	patients	patient	NOUN
dti-1304	46	18	with	with	ADP
dti-1304	46	19	cml	cml	PROPN
dti-1304	46	20	with	with	ADP
dti-1304	46	21	whom	whom	PRON
dti-1304	46	22	treatment	treatment	NOUN
dti-1304	46	23	with	with	ADP
dti-1304	46	24	interferon	interferon	PROPN
dti-1304	46	25	α	α	PROPN
dti-1304	46	26	had	have	AUX
dti-1304	46	27	failed	fail	VERB
dti-1304	46	28	,	,	PUNCT
dti-1304	46	29	as	as	ADV
dti-1304	46	30	well	well	ADV
dti-1304	46	31	as	as	ADP
dti-1304	46	32	those	those	PRON
dti-1304	46	33	with	with	ADP
dti-1304	46	34	blast	blast	NOUN
dti-1304	46	35	crisis	crisis	NOUN
dti-1304	46	36	of	of	ADP
dti-1304	46	37	cml	cml	PROPN
dti-1304	46	38	or	or	CCONJ
dti-1304	46	39	bcr	bcr	PROPN
dti-1304	46	40	-	-	PUNCT
dti-1304	46	41	abl	abl	ADJ
dti-1304	46	42	-	-	ADJ
dti-1304	46	43	positive	positive	ADJ
dti-1304	46	44	acute	acute	ADJ
dti-1304	46	45	lymphoblastic	lymphoblastic	ADJ
dti-1304	46	46	leukemia	leukemia	NOUN
dti-1304	46	47	[	[	X
dti-1304	46	48	druker	druker	NOUN
dti-1304	46	49	et	et	PROPN
dti-1304	46	50	al	al	PROPN
dti-1304	46	51	.	.	PROPN
dti-1304	46	52	2001a	2001a	NUM
dti-1304	46	53	;	;	PUNCT
dti-1304	46	54	druker	druker	NOUN
dti-1304	46	55	et	et	PROPN
dti-1304	46	56	al	al	PROPN
dti-1304	46	57	.	.	PROPN
dti-1304	46	58	2001b	2001b	NUM
dti-1304	46	59	]	]	PUNCT
dti-1304	46	60	.	.	PUNCT
dti-1304	47	1	imatinib	imatinib	NOUN
dti-1304	47	2	was	be	AUX
dti-1304	47	3	later	later	ADV
dti-1304	47	4	revealed	reveal	VERB
dti-1304	47	5	to	to	PART
dti-1304	47	6	induce	induce	VERB
dti-1304	47	7	a	a	DET
dti-1304	47	8	sustained	sustained	ADJ
dti-1304	47	9	objective	objective	ADJ
dti-1304	47	10	response	response	NOUN
dti-1304	47	11	in	in	ADP
dti-1304	47	12	more	more	ADJ
dti-1304	47	13	than	than	ADP
dti-1304	47	14	half	half	NOUN
dti-1304	47	15	of	of	ADP
dti-1304	47	16	patients	patient	NOUN
dti-1304	47	17	with	with	ADP
dti-1304	47	18	an	an	DET
dti-1304	47	19	advanced	advanced	ADJ
dti-1304	47	20	unresectable	unresectable	ADJ
dti-1304	47	21	or	or	CCONJ
dti-1304	47	22	metastatic	metastatic	ADJ
dti-1304	47	23	gist	gist	NOUN
dti-1304	47	24	[	[	X
dti-1304	47	25	demetri	demetri	PROPN
dti-1304	47	26	et	et	PROPN
dti-1304	47	27	al	al	PROPN
dti-1304	47	28	.	.	PROPN
dti-1304	47	29	2002	2002	NUM
dti-1304	47	30	]	]	PUNCT
dti-1304	47	31	.	.	PUNCT
dti-1304	48	1	imatinib	imatinib	NOUN
dti-1304	48	2	has	have	AUX
dti-1304	48	3	now	now	ADV
dti-1304	48	4	been	be	AUX
dti-1304	48	5	widely	widely	ADV
dti-1304	48	6	approved	approve	VERB
dti-1304	48	7	for	for	ADP
dti-1304	48	8	the	the	DET
dti-1304	48	9	treatment	treatment	NOUN
dti-1304	48	10	of	of	ADP
dti-1304	48	11	cml	cml	PROPN
dti-1304	48	12	and	and	CCONJ
dti-1304	48	13	unresectable	unresectable	ADJ
dti-1304	48	14	and/or	and/or	CCONJ
dti-1304	48	15	metastatic	metastatic	ADJ
dti-1304	48	16	c	c	NOUN
dti-1304	48	17	-	-	PUNCT
dti-1304	48	18	kit	kit	NOUN
dti-1304	48	19	(	(	PUNCT
dti-1304	48	20	cd117)-positive	cd117)-positive	ADJ
dti-1304	48	21	gist	gist	NOUN
dti-1304	48	22	.	.	PUNCT
dti-1304	49	1	systemic	systemic	ADJ
dti-1304	49	2	sclerosis	sclerosis	NOUN
dti-1304	49	3	systemic	systemic	ADJ
dti-1304	49	4	sclerosis	sclerosis	NOUN
dti-1304	49	5	(	(	PUNCT
dti-1304	49	6	ssc	ssc	NOUN
dti-1304	49	7	;	;	PUNCT
dti-1304	49	8	scleroderma	scleroderma	NOUN
dti-1304	49	9	)	)	PUNCT
dti-1304	49	10	is	be	AUX
dti-1304	49	11	characterized	characterize	VERB
dti-1304	49	12	by	by	ADP
dti-1304	49	13	vascular	vascular	ADJ
dti-1304	49	14	damage	damage	NOUN
dti-1304	49	15	and	and	CCONJ
dti-1304	49	16	excessive	excessive	ADJ
dti-1304	49	17	fi	fi	NOUN
dti-1304	49	18	brotic	brotic	ADJ
dti-1304	49	19	response	response	NOUN
dti-1304	49	20	on	on	ADP
dti-1304	49	21	the	the	DET
dti-1304	49	22	basis	basis	NOUN
dti-1304	49	23	of	of	ADP
dti-1304	49	24	immunologic	immunologic	ADJ
dti-1304	49	25	abnormalities	abnormality	NOUN
dti-1304	49	26	(	(	PUNCT
dti-1304	49	27	“	"	PUNCT
dti-1304	49	28	immunodistortion	immunodistortion	NOUN
dti-1304	49	29	”	"	PUNCT
dti-1304	49	30	)	)	PUNCT
dti-1304	49	31	.	.	PUNCT
dti-1304	50	1	the	the	DET
dti-1304	50	2	progression	progression	NOUN
dti-1304	50	3	of	of	ADP
dti-1304	50	4	organ	organ	NOUN
dti-1304	50	5	damage	damage	NOUN
dti-1304	50	6	is	be	AUX
dti-1304	50	7	usually	usually	ADV
dti-1304	50	8	insidious	insidious	ADJ
dti-1304	50	9	in	in	ADP
dti-1304	50	10	ssc	ssc	PROPN
dti-1304	50	11	,	,	PUNCT
dti-1304	50	12	with	with	ADP
dti-1304	50	13	the	the	DET
dti-1304	50	14	exception	exception	NOUN
dti-1304	50	15	of	of	ADP
dti-1304	50	16	scleroderma	scleroderma	NOUN
dti-1304	50	17	renal	renal	ADJ
dti-1304	50	18	crisis	crisis	NOUN
dti-1304	50	19	which	which	PRON
dti-1304	50	20	can	can	AUX
dti-1304	50	21	be	be	AUX
dti-1304	50	22	successfully	successfully	ADV
dti-1304	50	23	treated	treat	VERB
dti-1304	50	24	with	with	ADP
dti-1304	50	25	angiotensinconverting	angiotensinconverte	VERB
dti-1304	50	26	enzyme	enzyme	NOUN
dti-1304	50	27	inhibitors	inhibitor	NOUN
dti-1304	50	28	.	.	PUNCT
dti-1304	51	1	therefore	therefore	ADV
dti-1304	51	2	,	,	PUNCT
dti-1304	51	3	overall	overall	ADJ
dti-1304	51	4	disappointing	disappointing	ADJ
dti-1304	51	5	response	response	NOUN
dti-1304	51	6	to	to	ADP
dti-1304	51	7	corticosteroids	corticosteroid	NOUN
dti-1304	51	8	has	have	AUX
dti-1304	51	9	been	be	AUX
dti-1304	51	10	attributed	attribute	VERB
dti-1304	51	11	to	to	ADP
dti-1304	51	12	the	the	DET
dti-1304	51	13	paucity	paucity	NOUN
dti-1304	51	14	of	of	ADP
dti-1304	51	15	involvement	involvement	NOUN
dti-1304	51	16	of	of	ADP
dti-1304	51	17	active	active	ADJ
dti-1304	51	18	infl	infl	PROPN
dti-1304	51	19	ammation	ammation	PROPN
dti-1304	51	20	,	,	PUNCT
dti-1304	51	21	characterized	characterize	VERB
dti-1304	51	22	by	by	ADP
dti-1304	51	23	massive	massive	ADJ
dti-1304	51	24	leukocyte	leukocyte	NOUN
dti-1304	51	25	infi	infi	PROPN
dti-1304	51	26	ltration	ltration	NOUN
dti-1304	51	27	.	.	PUNCT
dti-1304	52	1	for	for	ADP
dti-1304	52	2	this	this	DET
dti-1304	52	3	reason	reason	NOUN
dti-1304	52	4	,	,	PUNCT
dti-1304	52	5	disease	disease	NOUN
dti-1304	52	6	-	-	PUNCT
dti-1304	52	7	modifying	modify	VERB
dti-1304	52	8	drugs	drug	NOUN
dti-1304	52	9	for	for	ADP
dti-1304	52	10	ssc	ssc	NOUN
dti-1304	52	11	have	have	AUX
dti-1304	52	12	not	not	PART
dti-1304	52	13	been	be	AUX
dti-1304	52	14	available	available	ADJ
dti-1304	52	15	to	to	ADP
dti-1304	52	16	date	date	NOUN
dti-1304	53	1	[	[	X
dti-1304	53	2	wollheim	wollheim	NOUN
dti-1304	53	3	,	,	PUNCT
dti-1304	53	4	2007	2007	NUM
dti-1304	53	5	]	]	PUNCT
dti-1304	53	6	.	.	PUNCT
dti-1304	54	1	as	as	ADP
dti-1304	54	2	for	for	ADP
dti-1304	54	3	vascular	vascular	ADJ
dti-1304	54	4	damage	damage	NOUN
dti-1304	54	5	,	,	PUNCT
dti-1304	54	6	inhibitors	inhibitor	NOUN
dti-1304	54	7	targeting	target	VERB
dti-1304	54	8	endothelin	endothelin	PROPN
dti-1304	54	9	receptors	receptor	NOUN
dti-1304	54	10	,	,	PUNCT
dti-1304	54	11	such	such	ADJ
dti-1304	54	12	as	as	ADP
dti-1304	54	13	bosentan	bosentan	ADJ
dti-1304	54	14	,	,	PUNCT
dti-1304	54	15	represent	represent	VERB
dti-1304	54	16	a	a	DET
dti-1304	54	17	breakthrough	breakthrough	NOUN
dti-1304	54	18	in	in	ADP
dti-1304	54	19	the	the	DET
dti-1304	54	20	treatment	treatment	NOUN
dti-1304	54	21	of	of	ADP
dti-1304	54	22	pulmonary	pulmonary	ADJ
dti-1304	54	23	arterial	arterial	ADJ
dti-1304	54	24	hypertension	hypertension	NOUN
dti-1304	54	25	(	(	PUNCT
dti-1304	54	26	pah	pah	PROPN
dti-1304	54	27	)	)	PUNCT
dti-1304	54	28	,	,	PUNCT
dti-1304	54	29	a	a	DET
dti-1304	54	30	complication	complication	NOUN
dti-1304	54	31	with	with	ADP
dti-1304	54	32	one	one	NUM
dti-1304	54	33	of	of	ADP
dti-1304	54	34	the	the	DET
dti-1304	54	35	worst	bad	ADJ
dti-1304	54	36	prognosis	prognosis	NOUN
dti-1304	54	37	in	in	ADP
dti-1304	54	38	ssc	ssc	PROPN
dti-1304	54	39	,	,	PUNCT
dti-1304	54	40	systemic	systemic	ADJ
dti-1304	54	41	lupus	lupus	PROPN
dti-1304	54	42	erythematosus	erythematosus	NOUN
dti-1304	54	43	(	(	PUNCT
dti-1304	54	44	sle	sle	PROPN
dti-1304	54	45	)	)	PUNCT
dti-1304	54	46	or	or	CCONJ
dti-1304	54	47	mixed	mixed	ADJ
dti-1304	54	48	connective	connective	ADJ
dti-1304	54	49	tissue	tissue	NOUN
dti-1304	54	50	241	241	NUM
dti-1304	54	51	pdgf	pdgf	NOUN
dti-1304	54	52	as	as	ADP
dti-1304	54	53	a	a	DET
dti-1304	54	54	target	target	NOUN
dti-1304	54	55	for	for	ADP
dti-1304	54	56	systemic	systemic	ADJ
dti-1304	54	57	autoimmune	autoimmune	ADJ
dti-1304	54	58	diseases	disease	NOUN
dti-1304	54	59	drug	drug	NOUN
dti-1304	54	60	target	target	NOUN
dti-1304	54	61	insights	insight	NOUN
dti-1304	54	62	2007:2	2007:2	NUM
dti-1304	54	63	disease	disease	NOUN
dti-1304	54	64	(	(	PUNCT
dti-1304	54	65	mctd	mctd	NOUN
dti-1304	54	66	)	)	PUNCT
dti-1304	55	1	[	[	X
dti-1304	55	2	denton	denton	X
dti-1304	55	3	et	et	PROPN
dti-1304	55	4	al	al	PROPN
dti-1304	55	5	.	.	PROPN
dti-1304	55	6	2006	2006	NUM
dti-1304	55	7	;	;	PUNCT
dti-1304	55	8	kondo	kondo	PROPN
dti-1304	55	9	,	,	PUNCT
dti-1304	55	10	2001	2001	NUM
dti-1304	55	11	]	]	PUNCT
dti-1304	55	12	.	.	PUNCT
dti-1304	56	1	bosentan	bosentan	PROPN
dti-1304	56	2	may	may	AUX
dti-1304	56	3	also	also	ADV
dti-1304	56	4	reduce	reduce	VERB
dti-1304	56	5	the	the	DET
dti-1304	56	6	fibrotic	fibrotic	ADJ
dti-1304	56	7	process	process	NOUN
dti-1304	56	8	via	via	ADP
dti-1304	56	9	its	its	PRON
dti-1304	56	10	inhibitory	inhibitory	ADJ
dti-1304	56	11	effect	effect	NOUN
dti-1304	56	12	on	on	ADP
dti-1304	56	13	fibroblasts	fibroblast	NOUN
dti-1304	56	14	[	[	X
dti-1304	56	15	braun	braun	NOUN
dti-1304	56	16	-	-	PUNCT
dti-1304	56	17	moscovici	moscovici	NOUN
dti-1304	56	18	et	et	PROPN
dti-1304	56	19	al	al	PROPN
dti-1304	56	20	.	.	PROPN
dti-1304	56	21	2004	2004	NUM
dti-1304	56	22	]	]	PUNCT
dti-1304	56	23	,	,	PUNCT
dti-1304	56	24	although	although	SCONJ
dti-1304	56	25	these	these	DET
dti-1304	56	26	effects	effect	NOUN
dti-1304	56	27	have	have	AUX
dti-1304	56	28	not	not	PART
dti-1304	56	29	yet	yet	ADV
dti-1304	56	30	been	be	AUX
dti-1304	56	31	proven	prove	VERB
dti-1304	56	32	in	in	ADP
dti-1304	56	33	clinical	clinical	ADJ
dti-1304	56	34	trials	trial	NOUN
dti-1304	56	35	.	.	PUNCT
dti-1304	57	1	at	at	ADP
dti-1304	57	2	the	the	DET
dti-1304	57	3	same	same	ADJ
dti-1304	57	4	time	time	NOUN
dti-1304	57	5	,	,	PUNCT
dti-1304	57	6	a	a	DET
dti-1304	57	7	recent	recent	ADJ
dti-1304	57	8	report	report	NOUN
dti-1304	57	9	describing	describe	VERB
dti-1304	57	10	a	a	DET
dti-1304	57	11	stimulatory	stimulatory	NOUN
dti-1304	57	12	autoantibody	autoantibody	VERB
dti-1304	57	13	against	against	ADP
dti-1304	57	14	pdgf	pdgf	NOUN
dti-1304	57	15	-	-	PUNCT
dti-1304	57	16	r	r	NOUN
dti-1304	57	17	is	be	AUX
dti-1304	57	18	of	of	ADP
dti-1304	57	19	great	great	ADJ
dti-1304	57	20	interest	interest	NOUN
dti-1304	57	21	in	in	ADP
dti-1304	57	22	view	view	NOUN
dti-1304	57	23	of	of	ADP
dti-1304	57	24	the	the	DET
dti-1304	57	25	pathogenesis	pathogenesis	NOUN
dti-1304	57	26	and	and	CCONJ
dti-1304	57	27	management	management	NOUN
dti-1304	57	28	of	of	ADP
dti-1304	57	29	fi	fi	NOUN
dti-1304	57	30	brosis	brosis	NOUN
dti-1304	57	31	in	in	ADP
dti-1304	57	32	ssc	ssc	PROPN
dti-1304	58	1	[	[	X
dti-1304	58	2	baroni	baroni	X
dti-1304	58	3	et	et	PROPN
dti-1304	58	4	al	al	PROPN
dti-1304	58	5	.	.	PROPN
dti-1304	58	6	2006	2006	NUM
dti-1304	58	7	]	]	PUNCT
dti-1304	58	8	.	.	PUNCT
dti-1304	59	1	although	although	SCONJ
dti-1304	59	2	the	the	DET
dti-1304	59	3	determination	determination	NOUN
dti-1304	59	4	of	of	ADP
dti-1304	59	5	autoantibodies	autoantibody	NOUN
dti-1304	59	6	recognizing	recognize	VERB
dti-1304	59	7	nuclear	nuclear	ADJ
dti-1304	59	8	components	component	NOUN
dti-1304	59	9	have	have	AUX
dti-1304	59	10	been	be	AUX
dti-1304	59	11	useful	useful	ADJ
dti-1304	59	12	in	in	ADP
dti-1304	59	13	defi	defi	PROPN
dti-1304	59	14	ning	ning	PROPN
dti-1304	59	15	clinical	clinical	PROPN
dti-1304	59	16	subgroup	subgroup	NOUN
dti-1304	59	17	of	of	ADP
dti-1304	59	18	ssc	ssc	PROPN
dti-1304	59	19	,	,	PUNCT
dti-1304	59	20	antinuclear	antinuclear	ADJ
dti-1304	59	21	antibodies	antibody	NOUN
dti-1304	59	22	(	(	PUNCT
dti-1304	59	23	anas	anas	PROPN
dti-1304	59	24	)	)	PUNCT
dti-1304	59	25	have	have	AUX
dti-1304	59	26	not	not	PART
dti-1304	59	27	been	be	AUX
dti-1304	59	28	shown	show	VERB
dti-1304	59	29	to	to	PART
dti-1304	59	30	be	be	AUX
dti-1304	59	31	directly	directly	ADV
dti-1304	59	32	pathogenic	pathogenic	ADJ
dti-1304	59	33	.	.	PUNCT
dti-1304	60	1	in	in	ADP
dti-1304	60	2	contrast	contrast	NOUN
dti-1304	60	3	to	to	ADP
dti-1304	60	4	this	this	PRON
dti-1304	60	5	,	,	PUNCT
dti-1304	60	6	stimulatory	stimulatory	ADJ
dti-1304	60	7	anti	anti	ADJ
dti-1304	60	8	-	-	ADJ
dti-1304	60	9	pdgf	pdgf	ADJ
dti-1304	60	10	-	-	PUNCT
dti-1304	60	11	r	r	NOUN
dti-1304	60	12	antibodies	antibody	NOUN
dti-1304	60	13	exclusively	exclusively	ADV
dti-1304	60	14	found	find	VERB
dti-1304	60	15	in	in	ADP
dti-1304	60	16	sera	sera	NOUN
dti-1304	60	17	from	from	ADP
dti-1304	60	18	ssc	ssc	NOUN
dti-1304	60	19	patients	patient	NOUN
dti-1304	60	20	were	be	AUX
dti-1304	60	21	demonstrated	demonstrate	VERB
dti-1304	60	22	to	to	PART
dti-1304	60	23	activate	activate	VERB
dti-1304	60	24	pdgf	pdgf	ADJ
dti-1304	60	25	-	-	PUNCT
dti-1304	60	26	r	r	NOUN
dti-1304	60	27	and	and	CCONJ
dti-1304	60	28	induce	induce	VERB
dti-1304	60	29	the	the	DET
dti-1304	60	30	upregulation	upregulation	NOUN
dti-1304	60	31	of	of	ADP
dti-1304	60	32	the	the	DET
dti-1304	60	33	ha	ha	INTJ
dti-1304	60	34	-	-	PUNCT
dti-1304	60	35	ras	ras	NOUN
dti-1304	60	36	-	-	NOUN
dti-1304	60	37	erk1/2	erk1/2	PROPN
dti-1304	60	38	(	(	PUNCT
dti-1304	60	39	external	external	ADJ
dti-1304	60	40	signal	signal	NOUN
dti-1304	60	41	regulated	regulate	VERB
dti-1304	60	42	kinases	kinase	NOUN
dti-1304	60	43	1	1	NUM
dti-1304	60	44	and	and	CCONJ
dti-1304	60	45	2	2	NUM
dti-1304	60	46	)	)	PUNCT
dti-1304	60	47	cascade	cascade	NOUN
dti-1304	60	48	.	.	PUNCT
dti-1304	61	1	this	this	PRON
dti-1304	61	2	stimulated	stimulate	VERB
dti-1304	61	3	the	the	DET
dti-1304	61	4	expression	expression	NOUN
dti-1304	61	5	of	of	ADP
dti-1304	61	6	type	type	NOUN
dti-1304	61	7	i	i	PRON
dti-1304	61	8	collagen	collagen	NOUN
dti-1304	61	9	gene	gene	NOUN
dti-1304	61	10	expression	expression	NOUN
dti-1304	61	11	and	and	CCONJ
dti-1304	61	12	α	α	NOUN
dti-1304	61	13	-	-	ADJ
dti-1304	61	14	smooth	smooth	ADJ
dti-1304	61	15	muscle	muscle	NOUN
dti-1304	61	16	actin	actin	NOUN
dti-1304	61	17	(	(	PUNCT
dti-1304	61	18	α	α	NOUN
dti-1304	61	19	-	-	PUNCT
dti-1304	61	20	sma	sma	NOUN
dti-1304	61	21	)	)	PUNCT
dti-1304	62	1	[	[	X
dti-1304	62	2	baroni	baroni	X
dti-1304	62	3	et	et	PROPN
dti-1304	62	4	al	al	PROPN
dti-1304	62	5	.	.	PROPN
dti-1304	63	1	2006	2006	NUM
dti-1304	63	2	]	]	PUNCT
dti-1304	63	3	which	which	PRON
dti-1304	63	4	resembles	resemble	VERB
dti-1304	63	5	the	the	DET
dti-1304	63	6	case	case	NOUN
dti-1304	63	7	of	of	ADP
dti-1304	63	8	anti	anti	ADJ
dti-1304	63	9	-	-	ADJ
dti-1304	63	10	thyroid	thyroid	ADJ
dti-1304	63	11	stimulating	stimulate	VERB
dti-1304	63	12	hormone	hormone	NOUN
dti-1304	63	13	antibodies	antibody	NOUN
dti-1304	63	14	developing	develop	VERB
dti-1304	63	15	hyperthyroidism	hyperthyroidism	NOUN
dti-1304	63	16	.	.	PUNCT
dti-1304	64	1	early	early	ADV
dti-1304	64	2	in	in	ADP
dti-1304	64	3	2007	2007	NUM
dti-1304	64	4	,	,	PUNCT
dti-1304	64	5	distler	distler	NOUN
dti-1304	64	6	et	et	PROPN
dti-1304	64	7	al	al	PROPN
dti-1304	64	8	.	.	PROPN
dti-1304	64	9	reported	report	VERB
dti-1304	64	10	that	that	SCONJ
dti-1304	64	11	imatinib	imatinib	NOUN
dti-1304	64	12	reduced	reduce	VERB
dti-1304	64	13	basal	basal	NOUN
dti-1304	64	14	and	and	CCONJ
dti-1304	64	15	pdgfor	pdgfor	ADP
dti-1304	64	16	tgf	tgf	PROPN
dti-1304	64	17	-	-	PUNCT
dti-1304	64	18	β	β	NOUN
dti-1304	64	19	-	-	PUNCT
dti-1304	64	20	stimulated	stimulated	ADJ
dti-1304	64	21	synthesis	synthesis	NOUN
dti-1304	64	22	of	of	ADP
dti-1304	64	23	extracellular	extracellular	ADJ
dti-1304	64	24	matrix	matrix	NOUN
dti-1304	64	25	(	(	PUNCT
dti-1304	64	26	ecm	ecm	NOUN
dti-1304	64	27	)	)	PUNCT
dti-1304	64	28	proteins	protein	NOUN
dti-1304	64	29	such	such	ADJ
dti-1304	64	30	as	as	ADP
dti-1304	64	31	collagen	collagen	NOUN
dti-1304	64	32	and	and	CCONJ
dti-1304	64	33	fibronectin	fibronectin	NOUN
dti-1304	64	34	;	;	PUNCT
dti-1304	64	35	and	and	CCONJ
dti-1304	64	36	that	that	SCONJ
dti-1304	64	37	a	a	DET
dti-1304	64	38	50–150	50–150	NUM
dti-1304	64	39	mg	mg	NOUN
dti-1304	64	40	/	/	SYM
dti-1304	64	41	kg	kg	PROPN
dti-1304	64	42	/	/	SYM
dti-1304	64	43	day	day	NOUN
dti-1304	64	44	intraperitoneal	intraperitoneal	ADJ
dti-1304	64	45	administration	administration	NOUN
dti-1304	64	46	of	of	ADP
dti-1304	64	47	imatinib	imatinib	NOUN
dti-1304	64	48	effectively	effectively	ADV
dti-1304	64	49	inhibited	inhibit	VERB
dti-1304	64	50	dermal	dermal	ADJ
dti-1304	64	51	thickness	thickness	NOUN
dti-1304	64	52	,	,	PUNCT
dti-1304	64	53	the	the	DET
dti-1304	64	54	number	number	NOUN
dti-1304	64	55	of	of	ADP
dti-1304	64	56	myofi	myofi	NOUN
dti-1304	64	57	broblasts	broblast	NOUN
dti-1304	64	58	and	and	CCONJ
dti-1304	64	59	synthesis	synthesis	NOUN
dti-1304	64	60	of	of	ADP
dti-1304	64	61	ecm	ecm	NOUN
dti-1304	64	62	proteins	protein	NOUN
dti-1304	64	63	in	in	ADP
dti-1304	64	64	bleomycin	bleomycin	NOUN
dti-1304	64	65	-	-	PUNCT
dti-1304	64	66	induced	induce	VERB
dti-1304	64	67	dermal	dermal	NOUN
dti-1304	64	68	fi	fi	NOUN
dti-1304	64	69	brosis	brosis	NOUN
dti-1304	64	70	model	model	NOUN
dti-1304	64	71	—	—	PUNCT
dti-1304	64	72	all	all	PRON
dti-1304	64	73	without	without	ADP
dti-1304	64	74	evidence	evidence	NOUN
dti-1304	64	75	of	of	ADP
dti-1304	64	76	toxic	toxic	ADJ
dti-1304	64	77	adverse	adverse	ADJ
dti-1304	64	78	effects	effect	NOUN
dti-1304	65	1	[	[	X
dti-1304	65	2	distler	distler	NOUN
dti-1304	65	3	et	et	PROPN
dti-1304	65	4	al	al	PROPN
dti-1304	65	5	.	.	PROPN
dti-1304	65	6	2007	2007	NUM
dti-1304	65	7	]	]	PUNCT
dti-1304	65	8	.	.	PUNCT
dti-1304	66	1	a	a	DET
dti-1304	66	2	signifi	signifi	NOUN
dti-1304	66	3	ca	can	AUX
dti-1304	66	4	nt	not	PART
dti-1304	66	5	increase	increase	VERB
dti-1304	66	6	in	in	ADP
dti-1304	66	7	activated	activate	VERB
dti-1304	66	8	pdgf	pdgf	NOUN
dti-1304	66	9	-	-	PUNCT
dti-1304	66	10	rβ	rβ	NOUN
dti-1304	66	11	expression	expression	NOUN
dti-1304	66	12	in	in	ADP
dti-1304	66	13	idiopathic	idiopathic	ADJ
dti-1304	66	14	pah	pah	NOUN
dti-1304	66	15	lungs	lung	NOUN
dti-1304	66	16	compared	compare	VERB
dti-1304	66	17	with	with	ADP
dti-1304	66	18	healthy	healthy	ADJ
dti-1304	66	19	donor	donor	NOUN
dti-1304	66	20	lungs	lung	NOUN
dti-1304	66	21	,	,	PUNCT
dti-1304	66	22	and	and	CCONJ
dti-1304	66	23	successful	successful	ADJ
dti-1304	66	24	reversal	reversal	NOUN
dti-1304	66	25	of	of	ADP
dti-1304	66	26	pulmonary	pulmonary	ADJ
dti-1304	66	27	vascular	vascular	ADJ
dti-1304	66	28	remodeling	remodeling	NOUN
dti-1304	66	29	,	,	PUNCT
dti-1304	66	30	in	in	ADP
dti-1304	66	31	both	both	PRON
dti-1304	66	32	monocrotaline	monocrotaline	ADV
dti-1304	66	33	-	-	PUNCT
dti-1304	66	34	induced	induce	VERB
dti-1304	66	35	rat	rat	NOUN
dti-1304	66	36	model	model	NOUN
dti-1304	66	37	and	and	CCONJ
dti-1304	66	38	hypoxia	hypoxia	NOUN
dti-1304	66	39	-	-	PUNCT
dti-1304	66	40	induced	induce	VERB
dti-1304	66	41	mouse	mouse	NOUN
dti-1304	66	42	model	model	NOUN
dti-1304	66	43	of	of	ADP
dti-1304	66	44	pah	pah	PROPN
dti-1304	67	1	[	[	X
dti-1304	67	2	schermuly	schermuly	NOUN
dti-1304	67	3	et	et	PROPN
dti-1304	67	4	al	al	PROPN
dti-1304	67	5	.	.	PROPN
dti-1304	67	6	2005	2005	NUM
dti-1304	67	7	]	]	PUNCT
dti-1304	67	8	,	,	PUNCT
dti-1304	67	9	led	lead	VERB
dti-1304	67	10	to	to	ADP
dti-1304	67	11	the	the	DET
dti-1304	67	12	compassionate	compassionate	ADJ
dti-1304	67	13	treatment	treatment	NOUN
dti-1304	67	14	of	of	ADP
dti-1304	67	15	a	a	DET
dti-1304	67	16	patient	patient	NOUN
dti-1304	67	17	with	with	ADP
dti-1304	67	18	idiopathic	idiopathic	ADJ
dti-1304	67	19	pah	pah	NOUN
dti-1304	67	20	with	with	ADP
dti-1304	67	21	a	a	DET
dti-1304	67	22	daily	daily	ADJ
dti-1304	67	23	administration	administration	NOUN
dti-1304	67	24	of	of	ADP
dti-1304	67	25	200	200	NUM
dti-1304	67	26	mg	mg	NOUN
dti-1304	67	27	of	of	ADP
dti-1304	67	28	oral	oral	ADJ
dti-1304	67	29	imatinib	imatinib	NOUN
dti-1304	68	1	[	[	X
dti-1304	68	2	ghofrani	ghofrani	NOUN
dti-1304	68	3	et	et	PROPN
dti-1304	68	4	al	al	PROPN
dti-1304	68	5	.	.	PROPN
dti-1304	68	6	2005	2005	NUM
dti-1304	68	7	]	]	PUNCT
dti-1304	68	8	.	.	PUNCT
dti-1304	69	1	the	the	DET
dti-1304	69	2	patient	patient	NOUN
dti-1304	69	3	’s	’s	PART
dti-1304	69	4	condition	condition	NOUN
dti-1304	69	5	imatinib	imatinib	NOUN
dti-1304	69	6	gene	gene	NOUN
dti-1304	69	7	regulation	regulation	NOUN
dti-1304	69	8	figure	figure	NOUN
dti-1304	69	9	1	1	NUM
dti-1304	69	10	.	.	X
dti-1304	70	1	signaling	signal	VERB
dti-1304	70	2	through	through	ADP
dti-1304	70	3	the	the	DET
dti-1304	70	4	pdgf	pdgf	NOUN
dti-1304	70	5	-	-	PUNCT
dti-1304	70	6	r.	r.	NOUN
dti-1304	70	7	the	the	DET
dti-1304	70	8	binding	binding	NOUN
dti-1304	70	9	of	of	ADP
dti-1304	70	10	pdgf	pdgf	ADJ
dti-1304	70	11	dimer	dimer	NOUN
dti-1304	70	12	(	(	PUNCT
dti-1304	70	13	pdgf	pdgf	NOUN
dti-1304	70	14	-	-	PUNCT
dti-1304	70	15	bb	bb	NOUN
dti-1304	70	16	,	,	PUNCT
dti-1304	70	17	for	for	ADP
dti-1304	70	18	example	example	NOUN
dti-1304	70	19	)	)	PUNCT
dti-1304	70	20	to	to	PART
dti-1304	70	21	pdgf	pdgf	VERB
dti-1304	70	22	-	-	PUNCT
dti-1304	70	23	r	r	NOUN
dti-1304	70	24	results	result	NOUN
dti-1304	70	25	in	in	ADP
dti-1304	70	26	the	the	DET
dti-1304	70	27	tyrosine	tyrosine	NOUN
dti-1304	70	28	phosphorylation	phosphorylation	NOUN
dti-1304	70	29	of	of	ADP
dti-1304	70	30	its	its	PRON
dti-1304	70	31	cytoplasmic	cytoplasmic	ADJ
dti-1304	70	32	domain	domain	NOUN
dti-1304	70	33	,	,	PUNCT
dti-1304	70	34	where	where	SCONJ
dti-1304	70	35	many	many	ADJ
dti-1304	70	36	adapter	adapter	NOUN
dti-1304	70	37	proteins	protein	NOUN
dti-1304	70	38	and	and	CCONJ
dti-1304	70	39	kinases	kinase	NOUN
dti-1304	70	40	/	/	SYM
dti-1304	70	41	phosphatases	phosphatase	NOUN
dti-1304	70	42	assemble	assemble	VERB
dti-1304	70	43	and	and	CCONJ
dti-1304	70	44	augment	augment	VERB
dti-1304	70	45	the	the	DET
dti-1304	70	46	activation	activation	NOUN
dti-1304	70	47	signaling	signal	VERB
dti-1304	70	48	leading	lead	VERB
dti-1304	70	49	to	to	ADP
dti-1304	70	50	upregulation	upregulation	NOUN
dti-1304	70	51	of	of	ADP
dti-1304	70	52	gene	gene	NOUN
dti-1304	70	53	expressions	expression	NOUN
dti-1304	70	54	.	.	PUNCT
dti-1304	71	1	imatinib	imatinib	NOUN
dti-1304	71	2	inhibits	inhibit	VERB
dti-1304	71	3	the	the	DET
dti-1304	71	4	activation	activation	NOUN
dti-1304	71	5	of	of	ADP
dti-1304	71	6	pdgf	pdgf	ADJ
dti-1304	71	7	-	-	PUNCT
dti-1304	71	8	r	r	NOUN
dti-1304	71	9	tyrosine	tyrosine	NOUN
dti-1304	71	10	kinase	kinase	NOUN
dti-1304	71	11	.	.	PUNCT
dti-1304	72	1	242	242	NUM
dti-1304	72	2	kameda	kameda	PROPN
dti-1304	72	3	et	et	PROPN
dti-1304	72	4	al	al	PROPN
dti-1304	72	5	drug	drug	PROPN
dti-1304	72	6	target	target	NOUN
dti-1304	72	7	insights	insight	NOUN
dti-1304	72	8	2007:2	2007:2	NUM
dti-1304	72	9	improved	improve	VERB
dti-1304	72	10	impressively	impressively	ADV
dti-1304	72	11	over	over	ADP
dti-1304	72	12	3	3	NUM
dti-1304	72	13	months	month	NOUN
dti-1304	72	14	in	in	ADP
dti-1304	72	15	pulmonary	pulmonary	ADJ
dti-1304	72	16	vascular	vascular	ADJ
dti-1304	72	17	resistance	resistance	NOUN
dti-1304	72	18	(	(	PUNCT
dti-1304	72	19	from	from	ADP
dti-1304	72	20	1056	1056	NUM
dti-1304	72	21	dyn.sec.cm−5	dyn.sec.cm−5	NOUN
dti-1304	72	22	to	to	ADP
dti-1304	72	23	815	815	NUM
dti-1304	72	24	dyn.sec.cm−5	dyn.sec.cm−5	ADJ
dti-1304	72	25	)	)	PUNCT
dti-1304	72	26	,	,	PUNCT
dti-1304	72	27	six	six	NUM
dti-1304	72	28	-	-	PUNCT
dti-1304	72	29	minute	minute	NOUN
dti-1304	72	30	walk	walk	NOUN
dti-1304	72	31	distance	distance	NOUN
dti-1304	72	32	(	(	PUNCT
dti-1304	72	33	from	from	ADP
dti-1304	72	34	260	260	NUM
dti-1304	72	35	m	m	NOUN
dti-1304	72	36	to	to	ADP
dti-1304	72	37	383	383	NUM
dti-1304	72	38	m	m	NOUN
dti-1304	72	39	)	)	PUNCT
dti-1304	72	40	,	,	PUNCT
dti-1304	72	41	and	and	CCONJ
dti-1304	72	42	new	new	PROPN
dti-1304	72	43	york	york	PROPN
dti-1304	72	44	heart	heart	PROPN
dti-1304	72	45	association	association	PROPN
dti-1304	72	46	functional	functional	ADJ
dti-1304	72	47	class	class	NOUN
dti-1304	72	48	(	(	PUNCT
dti-1304	72	49	from	from	ADP
dti-1304	72	50	iv	iv	NUM
dti-1304	72	51	to	to	ADP
dti-1304	72	52	ii	ii	NUM
dti-1304	72	53	)	)	PUNCT
dti-1304	73	1	[	[	X
dti-1304	73	2	ghofrani	ghofrani	NOUN
dti-1304	73	3	et	et	PROPN
dti-1304	73	4	al	al	PROPN
dti-1304	73	5	.	.	PROPN
dti-1304	73	6	2005	2005	NUM
dti-1304	73	7	]	]	PUNCT
dti-1304	73	8	.	.	PUNCT
dti-1304	74	1	these	these	DET
dti-1304	74	2	reports	report	NOUN
dti-1304	74	3	provide	provide	VERB
dti-1304	74	4	the	the	DET
dti-1304	74	5	possibility	possibility	NOUN
dti-1304	74	6	that	that	SCONJ
dti-1304	74	7	imatinib	imatinib	NOUN
dti-1304	74	8	may	may	AUX
dti-1304	74	9	be	be	AUX
dti-1304	74	10	a	a	DET
dti-1304	74	11	disease	disease	NOUN
dti-1304	74	12	-	-	PUNCT
dti-1304	74	13	modifying	modify	VERB
dti-1304	74	14	drug	drug	NOUN
dti-1304	74	15	for	for	ADP
dti-1304	74	16	ssc	ssc	PROPN
dti-1304	74	17	.	.	PUNCT
dti-1304	75	1	on	on	ADP
dti-1304	75	2	the	the	DET
dti-1304	75	3	other	other	ADJ
dti-1304	75	4	hand	hand	NOUN
dti-1304	75	5	,	,	PUNCT
dti-1304	75	6	recombinant	recombinant	ADJ
dti-1304	75	7	human	human	ADJ
dti-1304	75	8	anti	anti	ADJ
dti-1304	75	9	-	-	ADJ
dti-1304	75	10	tgfβ1	tgfβ1	ADJ
dti-1304	75	11	antibody	antibody	NOUN
dti-1304	75	12	(	(	PUNCT
dti-1304	75	13	cat-192	cat-192	NOUN
dti-1304	75	14	)	)	PUNCT
dti-1304	75	15	showed	show	VERB
dti-1304	75	16	no	no	DET
dti-1304	75	17	evidence	evidence	NOUN
dti-1304	75	18	of	of	ADP
dti-1304	75	19	effi	effi	PROPN
dti-1304	75	20	cacy	cacy	NOUN
dti-1304	75	21	in	in	ADP
dti-1304	75	22	a	a	DET
dti-1304	75	23	multicenter	multicenter	NOUN
dti-1304	75	24	,	,	PUNCT
dti-1304	75	25	randomized	randomize	VERB
dti-1304	75	26	,	,	PUNCT
dti-1304	75	27	placebocontrolled	placebocontrolle	VERB
dti-1304	75	28	phase	phase	NOUN
dti-1304	75	29	i	i	PROPN
dti-1304	75	30	/	/	SYM
dti-1304	75	31	ii	ii	PROPN
dti-1304	75	32	trial	trial	NOUN
dti-1304	75	33	for	for	ADP
dti-1304	75	34	early	early	ADJ
dti-1304	75	35	-	-	PUNCT
dti-1304	75	36	stage	stage	NOUN
dti-1304	75	37	diffuse	diffuse	NOUN
dti-1304	75	38	cutaneous	cutaneous	ADJ
dti-1304	75	39	ssc	ssc	NOUN
dti-1304	76	1	[	[	X
dti-1304	76	2	denton	denton	PROPN
dti-1304	76	3	et	et	PROPN
dti-1304	76	4	al	al	PROPN
dti-1304	76	5	.	.	PROPN
dti-1304	76	6	2007	2007	NUM
dti-1304	76	7	]	]	PUNCT
dti-1304	76	8	.	.	PUNCT
dti-1304	77	1	the	the	DET
dti-1304	77	2	blockade	blockade	NOUN
dti-1304	77	3	of	of	ADP
dti-1304	77	4	multiple	multiple	ADJ
dti-1304	77	5	isoforms	isoform	NOUN
dti-1304	77	6	of	of	ADP
dti-1304	77	7	tgfβ	tgfβ	NOUN
dti-1304	77	8	may	may	AUX
dti-1304	77	9	be	be	AUX
dti-1304	77	10	required	require	VERB
dti-1304	77	11	for	for	ADP
dti-1304	77	12	an	an	DET
dti-1304	77	13	effective	effective	ADJ
dti-1304	77	14	inhibition	inhibition	NOUN
dti-1304	77	15	of	of	ADP
dti-1304	77	16	fi	fi	NOUN
dti-1304	77	17	brosis	brosis	NOUN
dti-1304	77	18	.	.	PUNCT
dti-1304	78	1	in	in	ADP
dti-1304	78	2	this	this	DET
dti-1304	78	3	context	context	NOUN
dti-1304	78	4	,	,	PUNCT
dti-1304	78	5	the	the	DET
dti-1304	78	6	pan	pan	NOUN
dti-1304	78	7	-	-	ADJ
dti-1304	78	8	isoform	isoform	NOUN
dti-1304	78	9	-	-	PUNCT
dti-1304	78	10	specifi	specifi	PROPN
dti-1304	78	11	c	c	PROPN
dti-1304	78	12	anti	anti	ADJ
dti-1304	78	13	-	-	ADJ
dti-1304	78	14	tgfβ	tgfβ	ADJ
dti-1304	78	15	antibody	antibody	NOUN
dti-1304	78	16	1d11	1d11	NOUN
dti-1304	78	17	could	could	AUX
dti-1304	78	18	be	be	AUX
dti-1304	78	19	potentially	potentially	ADV
dti-1304	78	20	effective	effective	ADJ
dti-1304	78	21	for	for	ADP
dti-1304	78	22	fi	fi	NOUN
dti-1304	78	23	brotic	brotic	ADJ
dti-1304	78	24	diseases	disease	NOUN
dti-1304	78	25	.	.	PUNCT
dti-1304	79	1	nonetheless	nonetheless	ADV
dti-1304	79	2	,	,	PUNCT
dti-1304	79	3	imatinib	imatinib	NOUN
dti-1304	79	4	has	have	VERB
dti-1304	79	5	the	the	DET
dti-1304	79	6	advantage	advantage	NOUN
dti-1304	79	7	of	of	ADP
dti-1304	79	8	inhibiting	inhibit	VERB
dti-1304	79	9	both	both	CCONJ
dti-1304	79	10	pdgf	pdgf	NOUN
dti-1304	79	11	and	and	CCONJ
dti-1304	79	12	tgfβ	tgfβ	ADJ
dti-1304	79	13	signaling	signal	VERB
dti-1304	79	14	via	via	ADP
dti-1304	79	15	pdgf	pdgf	NOUN
dti-1304	79	16	-	-	PUNCT
dti-1304	79	17	r	r	NOUN
dti-1304	79	18	and	and	CCONJ
dti-1304	79	19	c	c	NOUN
dti-1304	79	20	-	-	PUNCT
dti-1304	79	21	abl	abl	NOUN
dti-1304	79	22	,	,	PUNCT
dti-1304	79	23	respectively	respectively	ADV
dti-1304	79	24	.	.	PUNCT
dti-1304	80	1	interstitial	interstitial	ADJ
dti-1304	80	2	lung	lung	NOUN
dti-1304	80	3	disease	disease	NOUN
dti-1304	80	4	(	(	PUNCT
dti-1304	80	5	ild	ild	PROPN
dti-1304	80	6	)	)	PUNCT
dti-1304	80	7	in	in	ADP
dti-1304	80	8	ssc	ssc	NOUN
dti-1304	80	9	will	will	AUX
dti-1304	80	10	be	be	AUX
dti-1304	80	11	discussed	discuss	VERB
dti-1304	80	12	in	in	ADP
dti-1304	80	13	the	the	DET
dti-1304	80	14	following	follow	VERB
dti-1304	80	15	section	section	NOUN
dti-1304	80	16	.	.	PUNCT
dti-1304	81	1	ild	ild	PROPN
dti-1304	81	2	in	in	ADP
dti-1304	81	3	systemic	systemic	ADJ
dti-1304	81	4	rheumatic	rheumatic	ADJ
dti-1304	81	5	diseases	disease	NOUN
dti-1304	81	6	the	the	DET
dti-1304	81	7	lung	lung	NOUN
dti-1304	81	8	is	be	AUX
dti-1304	81	9	one	one	NUM
dti-1304	81	10	of	of	ADP
dti-1304	81	11	the	the	DET
dti-1304	81	12	vital	vital	ADJ
dti-1304	81	13	organs	organ	NOUN
dti-1304	81	14	involved	involve	VERB
dti-1304	81	15	most	most	ADV
dti-1304	81	16	frequently	frequently	ADV
dti-1304	81	17	in	in	ADP
dti-1304	81	18	systemic	systemic	ADJ
dti-1304	81	19	rheumatic	rheumatic	ADJ
dti-1304	81	20	diseases	disease	NOUN
dti-1304	81	21	,	,	PUNCT
dti-1304	81	22	and	and	CCONJ
dti-1304	81	23	the	the	DET
dti-1304	81	24	presence	presence	NOUN
dti-1304	81	25	of	of	ADP
dti-1304	81	26	ild	ild	PROPN
dti-1304	81	27	is	be	AUX
dti-1304	81	28	a	a	DET
dti-1304	81	29	signifi	signifi	NOUN
dti-1304	81	30	ca	can	AUX
dti-1304	81	31	nt	not	PART
dti-1304	81	32	prognostic	prognostic	ADJ
dti-1304	81	33	factor	factor	NOUN
dti-1304	81	34	of	of	ADP
dti-1304	81	35	polymyositis	polymyositis	PROPN
dti-1304	81	36	/	/	SYM
dti-1304	81	37	dermatomyositis	dermatomyositis	PROPN
dti-1304	81	38	(	(	PUNCT
dti-1304	81	39	pm	pm	NOUN
dti-1304	81	40	/	/	SYM
dti-1304	81	41	dm	dm	NOUN
dti-1304	81	42	)	)	PUNCT
dti-1304	81	43	,	,	PUNCT
dti-1304	81	44	rheumatoid	rheumatoid	VERB
dti-1304	81	45	arthritis	arthritis	NOUN
dti-1304	81	46	(	(	PUNCT
dti-1304	81	47	ra	ra	NOUN
dti-1304	81	48	)	)	PUNCT
dti-1304	81	49	,	,	PUNCT
dti-1304	81	50	systemic	systemic	ADJ
dti-1304	81	51	vasculitis	vasculitis	PROPN
dti-1304	81	52	syndromes	syndrome	NOUN
dti-1304	81	53	and	and	CCONJ
dti-1304	81	54	ssc	ssc	NOUN
dti-1304	81	55	.	.	PUNCT
dti-1304	82	1	the	the	DET
dti-1304	82	2	clinical	clinical	ADJ
dti-1304	82	3	courses	course	NOUN
dti-1304	82	4	of	of	ADP
dti-1304	82	5	patients	patient	NOUN
dti-1304	82	6	with	with	ADP
dti-1304	82	7	ild	ild	PROPN
dti-1304	82	8	associated	associate	VERB
dti-1304	82	9	with	with	ADP
dti-1304	82	10	those	those	DET
dti-1304	82	11	diseases	disease	NOUN
dti-1304	82	12	can	can	AUX
dti-1304	82	13	be	be	AUX
dti-1304	82	14	categorized	categorize	VERB
dti-1304	82	15	into	into	ADP
dti-1304	82	16	4	4	NUM
dti-1304	82	17	groups	group	NOUN
dti-1304	82	18	:	:	PUNCT
dti-1304	82	19	1	1	X
dti-1304	82	20	)	)	PUNCT
dti-1304	82	21	a	a	DET
dti-1304	82	22	/	/	SYM
dti-1304	82	23	sip	sip	NOUN
dti-1304	82	24	with	with	ADP
dti-1304	82	25	rapid	rapid	ADJ
dti-1304	82	26	deterioration	deterioration	NOUN
dti-1304	82	27	within	within	ADP
dti-1304	82	28	a	a	DET
dti-1304	82	29	month	month	NOUN
dti-1304	82	30	(	(	PUNCT
dti-1304	82	31	acute	acute	NOUN
dti-1304	82	32	)	)	PUNCT
dti-1304	82	33	or	or	CCONJ
dti-1304	82	34	within	within	ADP
dti-1304	82	35	2–3	2–3	NUM
dti-1304	82	36	months	month	NOUN
dti-1304	82	37	(	(	PUNCT
dti-1304	82	38	subacute	subacute	VERB
dti-1304	82	39	)	)	PUNCT
dti-1304	82	40	;	;	PUNCT
dti-1304	82	41	2	2	X
dti-1304	82	42	)	)	PUNCT
dti-1304	82	43	chronic	chronic	ADJ
dti-1304	82	44	progression	progression	NOUN
dti-1304	82	45	of	of	ADP
dti-1304	82	46	pulmonary	pulmonary	ADJ
dti-1304	82	47	fibrosis	fibrosis	NOUN
dti-1304	82	48	causing	cause	VERB
dti-1304	82	49	non	non	ADJ
dti-1304	82	50	-	-	ADJ
dti-1304	82	51	productive	productive	ADJ
dti-1304	82	52	coughing	coughing	NOUN
dti-1304	82	53	,	,	PUNCT
dti-1304	82	54	breath	breath	NOUN
dti-1304	82	55	-	-	PUNCT
dti-1304	82	56	shortening	shortening	NOUN
dti-1304	82	57	upon	upon	SCONJ
dti-1304	82	58	exertion	exertion	NOUN
dti-1304	82	59	,	,	PUNCT
dti-1304	82	60	and	and	CCONJ
dti-1304	82	61	occasionally	occasionally	ADV
dti-1304	82	62	leading	lead	VERB
dti-1304	82	63	to	to	ADP
dti-1304	82	64	respiratory	respiratory	ADJ
dti-1304	82	65	failure	failure	NOUN
dti-1304	82	66	after	after	ADP
dti-1304	82	67	more	more	ADJ
dti-1304	82	68	than	than	ADP
dti-1304	82	69	6	6	NUM
dti-1304	82	70	months	month	NOUN
dti-1304	82	71	;	;	PUNCT
dti-1304	82	72	3	3	X
dti-1304	82	73	)	)	PUNCT
dti-1304	82	74	acute	acute	ADJ
dti-1304	82	75	or	or	CCONJ
dti-1304	82	76	subacute	subacute	VERB
dti-1304	82	77	exacerbation	exacerbation	NOUN
dti-1304	82	78	of	of	ADP
dti-1304	82	79	chronic	chronic	ADJ
dti-1304	82	80	ild	ild	NOUN
dti-1304	82	81	that	that	PRON
dti-1304	82	82	is	be	AUX
dti-1304	82	83	recurrent	recurrent	ADJ
dti-1304	82	84	in	in	ADP
dti-1304	82	85	some	some	DET
dti-1304	82	86	cases	case	NOUN
dti-1304	82	87	;	;	PUNCT
dti-1304	82	88	and	and	CCONJ
dti-1304	82	89	4	4	X
dti-1304	82	90	)	)	PUNCT
dti-1304	82	91	asymptomatic	asymptomatic	ADJ
dti-1304	82	92	ild	ild	PROPN
dti-1304	82	93	detected	detect	VERB
dti-1304	82	94	in	in	ADP
dti-1304	82	95	a	a	DET
dti-1304	82	96	milder	mild	ADJ
dti-1304	82	97	form	form	NOUN
dti-1304	82	98	by	by	ADP
dti-1304	82	99	radiographic	radiographic	ADJ
dti-1304	82	100	examination	examination	NOUN
dti-1304	82	101	or	or	CCONJ
dti-1304	82	102	pulmonary	pulmonary	ADJ
dti-1304	82	103	function	function	NOUN
dti-1304	82	104	tests	test	NOUN
dti-1304	82	105	in	in	ADP
dti-1304	82	106	the	the	DET
dti-1304	82	107	absence	absence	NOUN
dti-1304	82	108	of	of	ADP
dti-1304	82	109	clinically	clinically	ADV
dti-1304	82	110	apparent	apparent	ADJ
dti-1304	82	111	signs	sign	NOUN
dti-1304	82	112	and	and	CCONJ
dti-1304	82	113	symptoms	symptom	NOUN
dti-1304	82	114	throughout	throughout	ADP
dti-1304	82	115	the	the	DET
dti-1304	82	116	observation	observation	NOUN
dti-1304	82	117	period	period	NOUN
dti-1304	83	1	[	[	X
dti-1304	83	2	kameda	kameda	NOUN
dti-1304	83	3	and	and	CCONJ
dti-1304	83	4	takeuchi	takeuchi	PROPN
dti-1304	83	5	,	,	PUNCT
dti-1304	83	6	2006	2006	NUM
dti-1304	83	7	]	]	PUNCT
dti-1304	83	8	.	.	PUNCT
dti-1304	84	1	the	the	DET
dti-1304	84	2	american	american	PROPN
dti-1304	84	3	thoracic	thoracic	PROPN
dti-1304	84	4	society	society	PROPN
dti-1304	84	5	/	/	SYM
dti-1304	84	6	european	european	ADJ
dti-1304	84	7	respiratory	respiratory	ADJ
dti-1304	84	8	society	society	NOUN
dti-1304	84	9	(	(	PUNCT
dti-1304	84	10	ats	ats	PROPN
dti-1304	84	11	/	/	SYM
dti-1304	84	12	ers	er	NOUN
dti-1304	84	13	)	)	PUNCT
dti-1304	84	14	international	international	ADJ
dti-1304	84	15	multidisciplinary	multidisciplinary	ADJ
dti-1304	84	16	consensus	consensus	NOUN
dti-1304	84	17	classifi	classifi	PROPN
dti-1304	84	18	cation	cation	NOUN
dti-1304	84	19	is	be	AUX
dti-1304	84	20	usually	usually	ADV
dti-1304	84	21	used	use	VERB
dti-1304	84	22	for	for	ADP
dti-1304	84	23	the	the	DET
dti-1304	84	24	classifi	classifi	PROPN
dti-1304	84	25	cation	cation	NOUN
dti-1304	84	26	of	of	ADP
dti-1304	84	27	idiopathic	idiopathic	ADJ
dti-1304	84	28	interstitial	interstitial	ADJ
dti-1304	84	29	pneumonias	pneumonia	NOUN
dti-1304	84	30	(	(	PUNCT
dti-1304	84	31	iip	iip	PROPN
dti-1304	84	32	)	)	PUNCT
dti-1304	85	1	[	[	X
dti-1304	85	2	american	american	ADJ
dti-1304	85	3	thoracic	thoracic	NOUN
dti-1304	85	4	society	society	NOUN
dti-1304	85	5	;	;	PUNCT
dti-1304	85	6	european	european	ADJ
dti-1304	85	7	respiratory	respiratory	ADJ
dti-1304	85	8	society	society	NOUN
dti-1304	85	9	2002	2002	NUM
dti-1304	85	10	]	]	PUNCT
dti-1304	85	11	.	.	PUNCT
dti-1304	86	1	diffuse	diffuse	VERB
dti-1304	86	2	alveolar	alveolar	ADJ
dti-1304	86	3	damage	damage	NOUN
dti-1304	86	4	(	(	PUNCT
dti-1304	86	5	dad	dad	NOUN
dti-1304	86	6	)	)	PUNCT
dti-1304	86	7	and	and	CCONJ
dti-1304	86	8	organizing	organize	VERB
dti-1304	86	9	pneumonia	pneumonia	NOUN
dti-1304	86	10	(	(	PUNCT
dti-1304	86	11	op	op	NOUN
dti-1304	86	12	)	)	PUNCT
dti-1304	86	13	usually	usually	ADV
dti-1304	86	14	develop	develop	VERB
dti-1304	86	15	acutely	acutely	ADV
dti-1304	86	16	or	or	CCONJ
dti-1304	86	17	subacutely	subacutely	ADV
dti-1304	86	18	,	,	PUNCT
dti-1304	86	19	while	while	SCONJ
dti-1304	86	20	non	non	ADJ
dti-1304	86	21	-	-	ADJ
dti-1304	86	22	specifi	specifi	ADJ
dti-1304	86	23	c	c	PROPN
dti-1304	86	24	organizing	organize	VERB
dti-1304	86	25	pneumonia	pneumonia	NOUN
dti-1304	86	26	(	(	PUNCT
dti-1304	86	27	nsip	nsip	NOUN
dti-1304	86	28	)	)	PUNCT
dti-1304	86	29	shows	show	VERB
dti-1304	86	30	a	a	DET
dti-1304	86	31	subacute	subacute	NOUN
dti-1304	86	32	course	course	NOUN
dti-1304	86	33	,	,	PUNCT
dti-1304	86	34	and	and	CCONJ
dti-1304	86	35	usual	usual	ADJ
dti-1304	86	36	interstitial	interstitial	ADJ
dti-1304	86	37	pneumonia	pneumonia	NOUN
dti-1304	86	38	(	(	PUNCT
dti-1304	86	39	uip	uip	PROPN
dti-1304	86	40	)	)	PUNCT
dti-1304	86	41	represents	represent	VERB
dti-1304	86	42	a	a	DET
dti-1304	86	43	chronic	chronic	ADJ
dti-1304	86	44	form	form	NOUN
dti-1304	86	45	of	of	ADP
dti-1304	86	46	ild	ild	PROPN
dti-1304	86	47	called	call	VERB
dti-1304	86	48	pulmonary	pulmonary	ADJ
dti-1304	86	49	fi	fi	NOUN
dti-1304	86	50	brosis	brosis	NOUN
dti-1304	86	51	.	.	PUNCT
dti-1304	87	1	however	however	ADV
dti-1304	87	2	,	,	PUNCT
dti-1304	87	3	whether	whether	SCONJ
dti-1304	87	4	ild	ild	PROPN
dti-1304	87	5	associated	associate	VERB
dti-1304	87	6	with	with	ADP
dti-1304	87	7	systemic	systemic	ADJ
dti-1304	87	8	rheumatic	rheumatic	ADJ
dti-1304	87	9	diseases	disease	NOUN
dti-1304	87	10	resembles	resemble	VERB
dti-1304	87	11	iip	iip	PROPN
dti-1304	87	12	remains	remain	VERB
dti-1304	87	13	debatable	debatable	ADJ
dti-1304	87	14	:	:	PUNCT
dti-1304	87	15	the	the	DET
dti-1304	87	16	histological	histological	ADJ
dti-1304	87	17	fi	fi	NOUN
dti-1304	87	18	ndings	nding	NOUN
dti-1304	87	19	may	may	AUX
dti-1304	87	20	consist	consist	VERB
dti-1304	87	21	of	of	ADP
dti-1304	87	22	the	the	DET
dti-1304	87	23	overlapping	overlap	VERB
dti-1304	87	24	features	feature	NOUN
dti-1304	87	25	of	of	ADP
dti-1304	87	26	two	two	NUM
dti-1304	87	27	or	or	CCONJ
dti-1304	87	28	more	more	ADJ
dti-1304	87	29	patterns	pattern	NOUN
dti-1304	87	30	,	,	PUNCT
dti-1304	87	31	nsip	nsip	NOUN
dti-1304	87	32	and	and	CCONJ
dti-1304	87	33	op	op	NOUN
dti-1304	87	34	,	,	PUNCT
dti-1304	87	35	or	or	CCONJ
dti-1304	87	36	nsip	nsip	NOUN
dti-1304	87	37	and	and	CCONJ
dti-1304	87	38	uip	uip	PROPN
dti-1304	87	39	.	.	PUNCT
dti-1304	88	1	moreover	moreover	ADV
dti-1304	88	2	,	,	PUNCT
dti-1304	88	3	patients	patient	NOUN
dti-1304	88	4	having	have	VERB
dti-1304	88	5	idiopathic	idiopathic	ADJ
dti-1304	88	6	uip	uip	NOUN
dti-1304	88	7	(	(	PUNCT
dti-1304	88	8	clinically	clinically	ADV
dti-1304	88	9	idiopathic	idiopathic	ADJ
dti-1304	88	10	pulmonary	pulmonary	ADJ
dti-1304	88	11	fi	fi	NOUN
dti-1304	88	12	brosis	brosis	NOUN
dti-1304	88	13	)	)	PUNCT
dti-1304	88	14	show	show	VERB
dti-1304	88	15	poorer	poor	ADJ
dti-1304	88	16	prognosis	prognosis	NOUN
dti-1304	88	17	compared	compare	VERB
dti-1304	88	18	to	to	ADP
dti-1304	88	19	patients	patient	NOUN
dti-1304	88	20	with	with	ADP
dti-1304	88	21	systemic	systemic	ADJ
dti-1304	88	22	rheumatic	rheumatic	ADJ
dti-1304	88	23	diseases	disease	NOUN
dti-1304	88	24	,	,	PUNCT
dti-1304	88	25	such	such	ADJ
dti-1304	88	26	as	as	ADP
dti-1304	88	27	ssc	ssc	NOUN
dti-1304	88	28	demonstrating	demonstrating	NOUN
dti-1304	88	29	uip	uip	PROPN
dti-1304	88	30	in	in	ADP
dti-1304	88	31	lung	lung	NOUN
dti-1304	88	32	histology	histology	NOUN
dti-1304	89	1	[	[	X
dti-1304	89	2	bouros	bouro	VERB
dti-1304	89	3	et	et	PROPN
dti-1304	89	4	al	al	PROPN
dti-1304	89	5	.	.	PROPN
dti-1304	89	6	2002	2002	NUM
dti-1304	89	7	]	]	PUNCT
dti-1304	89	8	.	.	PUNCT
dti-1304	90	1	nevertheless	nevertheless	ADV
dti-1304	90	2	,	,	PUNCT
dti-1304	90	3	patients	patient	NOUN
dti-1304	90	4	with	with	ADP
dti-1304	90	5	ild	ild	PROPN
dti-1304	90	6	associated	associate	VERB
dti-1304	90	7	with	with	ADP
dti-1304	90	8	systemic	systemic	ADJ
dti-1304	90	9	rheumatic	rheumatic	ADJ
dti-1304	90	10	diseases	disease	NOUN
dti-1304	90	11	also	also	ADV
dti-1304	90	12	tend	tend	VERB
dti-1304	90	13	to	to	PART
dti-1304	90	14	show	show	VERB
dti-1304	90	15	a	a	DET
dti-1304	90	16	favorable	favorable	ADJ
dti-1304	90	17	response	response	NOUN
dti-1304	90	18	to	to	ADP
dti-1304	90	19	corticosteroids	corticosteroid	NOUN
dti-1304	90	20	when	when	SCONJ
dti-1304	90	21	the	the	DET
dti-1304	90	22	lung	lung	NOUN
dti-1304	90	23	histology	histology	NOUN
dti-1304	90	24	reveals	reveal	VERB
dti-1304	90	25	op	op	NOUN
dti-1304	90	26	or	or	CCONJ
dti-1304	90	27	cellular	cellular	ADJ
dti-1304	90	28	nsip	nsip	NOUN
dti-1304	90	29	,	,	PUNCT
dti-1304	90	30	while	while	SCONJ
dti-1304	90	31	they	they	PRON
dti-1304	90	32	demonstrate	demonstrate	VERB
dti-1304	90	33	a	a	DET
dti-1304	90	34	relatively	relatively	ADV
dti-1304	90	35	poor	poor	ADJ
dti-1304	90	36	response	response	NOUN
dti-1304	90	37	when	when	SCONJ
dti-1304	90	38	the	the	DET
dti-1304	90	39	lung	lung	NOUN
dti-1304	90	40	histology	histology	NOUN
dti-1304	90	41	shows	show	VERB
dti-1304	90	42	dad	dad	NOUN
dti-1304	90	43	or	or	CCONJ
dti-1304	90	44	uip	uip	PROPN
dti-1304	90	45	;	;	PUNCT
dti-1304	90	46	fi	fi	NOUN
dti-1304	90	47	brotic	brotic	ADJ
dti-1304	90	48	nsip	nsip	NOUN
dti-1304	90	49	stands	stand	VERB
dti-1304	90	50	for	for	ADP
dti-1304	90	51	an	an	DET
dti-1304	90	52	intermediate	intermediate	ADJ
dti-1304	90	53	response	response	NOUN
dti-1304	90	54	.	.	PUNCT
dti-1304	91	1	the	the	DET
dti-1304	91	2	addition	addition	NOUN
dti-1304	91	3	of	of	ADP
dti-1304	91	4	a	a	DET
dti-1304	91	5	single	single	ADJ
dti-1304	91	6	immunosuppressive	immunosuppressive	ADJ
dti-1304	91	7	agent	agent	NOUN
dti-1304	91	8	or	or	CCONJ
dti-1304	91	9	the	the	DET
dti-1304	91	10	combination	combination	NOUN
dti-1304	91	11	of	of	ADP
dti-1304	91	12	2	2	NUM
dti-1304	91	13	or	or	CCONJ
dti-1304	91	14	more	more	ADJ
dti-1304	91	15	improved	improve	VERB
dti-1304	91	16	the	the	DET
dti-1304	91	17	mortality	mortality	NOUN
dti-1304	91	18	and	and	CCONJ
dti-1304	91	19	morbidity	morbidity	NOUN
dti-1304	91	20	of	of	ADP
dti-1304	91	21	rapidly	rapidly	ADV
dti-1304	91	22	or	or	CCONJ
dti-1304	91	23	slowly	slowly	ADV
dti-1304	91	24	progressive	progressive	ADJ
dti-1304	91	25	ild	ild	PROPN
dti-1304	91	26	associated	associate	VERB
dti-1304	91	27	with	with	ADP
dti-1304	91	28	pm	pm	NOUN
dti-1304	91	29	/	/	SYM
dti-1304	91	30	dm	dm	NOUN
dti-1304	91	31	or	or	CCONJ
dti-1304	91	32	ssc	ssc	NOUN
dti-1304	92	1	[	[	X
dti-1304	92	2	white	white	NOUN
dti-1304	92	3	et	et	PROPN
dti-1304	92	4	al	al	PROPN
dti-1304	92	5	.	.	PROPN
dti-1304	92	6	2000	2000	NUM
dti-1304	92	7	;	;	PUNCT
dti-1304	92	8	kameda	kameda	PROPN
dti-1304	92	9	et	et	PROPN
dti-1304	92	10	al	al	PROPN
dti-1304	92	11	.	.	PROPN
dti-1304	92	12	2005	2005	NUM
dti-1304	92	13	]	]	PUNCT
dti-1304	92	14	.	.	PUNCT
dti-1304	93	1	despite	despite	SCONJ
dti-1304	93	2	the	the	DET
dti-1304	93	3	intensifi	intensifi	NOUN
dti-1304	93	4	ed	ed	PROPN
dti-1304	93	5	immunosuppressive	immunosuppressive	ADJ
dti-1304	93	6	strategies	strategy	NOUN
dti-1304	93	7	,	,	PUNCT
dti-1304	93	8	a	a	DET
dti-1304	93	9	signifi	signifi	NOUN
dti-1304	93	10	ca	can	AUX
dti-1304	93	11	nt	not	PART
dti-1304	93	12	number	number	NOUN
dti-1304	93	13	of	of	ADP
dti-1304	93	14	ild	ild	PROPN
dti-1304	93	15	patients	patient	NOUN
dti-1304	93	16	resulted	result	VERB
dti-1304	93	17	in	in	ADP
dti-1304	93	18	fatal	fatal	ADJ
dti-1304	93	19	outcomes	outcome	NOUN
dti-1304	93	20	.	.	PUNCT
dti-1304	94	1	because	because	SCONJ
dti-1304	94	2	the	the	DET
dti-1304	94	3	pathological	pathological	ADJ
dti-1304	94	4	examination	examination	NOUN
dti-1304	94	5	of	of	ADP
dti-1304	94	6	ild	ild	PROPN
dti-1304	94	7	with	with	ADP
dti-1304	94	8	poor	poor	ADJ
dti-1304	94	9	prognosis	prognosis	NOUN
dti-1304	94	10	,	,	PUNCT
dti-1304	94	11	dad	dad	NOUN
dti-1304	94	12	and	and	CCONJ
dti-1304	94	13	uip	uip	PROPN
dti-1304	94	14	,	,	PUNCT
dti-1304	94	15	shares	share	VERB
dti-1304	94	16	an	an	DET
dti-1304	94	17	excessive	excessive	ADJ
dti-1304	94	18	fibrosis	fibrosis	NOUN
dti-1304	94	19	,	,	PUNCT
dti-1304	94	20	another	another	DET
dti-1304	94	21	therapeutic	therapeutic	ADJ
dti-1304	94	22	strategy	strategy	NOUN
dti-1304	94	23	such	such	ADJ
dti-1304	94	24	as	as	ADP
dti-1304	94	25	anti	anti	ADJ
dti-1304	94	26	-	-	ADJ
dti-1304	94	27	fi	fi	ADJ
dti-1304	94	28	brotic	brotic	ADJ
dti-1304	94	29	agents	agent	NOUN
dti-1304	94	30	is	be	AUX
dti-1304	94	31	necessary	necessary	ADJ
dti-1304	94	32	.	.	PUNCT
dti-1304	95	1	pirfenidone	pirfenidone	NOUN
dti-1304	95	2	,	,	PUNCT
dti-1304	95	3	nacetylcysteine	nacetylcysteine	ADJ
dti-1304	95	4	and	and	CCONJ
dti-1304	95	5	interferon	interferon	ADJ
dti-1304	95	6	-	-	PUNCT
dti-1304	95	7	γ	γ	NOUN
dti-1304	95	8	have	have	AUX
dti-1304	95	9	been	be	AUX
dti-1304	95	10	shown	show	VERB
dti-1304	95	11	to	to	PART
dti-1304	95	12	be	be	AUX
dti-1304	95	13	potentially	potentially	ADV
dti-1304	95	14	effective	effective	ADJ
dti-1304	95	15	for	for	ADP
dti-1304	95	16	the	the	DET
dti-1304	95	17	prevention	prevention	NOUN
dti-1304	95	18	of	of	ADP
dti-1304	95	19	lung	lung	NOUN
dti-1304	95	20	fi	fi	NOUN
dti-1304	95	21	brosis	brosis	NOUN
dti-1304	96	1	[	[	X
dti-1304	96	2	american	american	PROPN
dti-1304	96	3	thoracic	thoracic	NOUN
dti-1304	96	4	society	society	NOUN
dti-1304	96	5	2000	2000	NUM
dti-1304	96	6	]	]	PUNCT
dti-1304	96	7	.	.	PUNCT
dti-1304	97	1	at	at	ADP
dti-1304	97	2	the	the	DET
dti-1304	97	3	end	end	NOUN
dti-1304	97	4	of	of	ADP
dti-1304	97	5	the	the	DET
dti-1304	97	6	last	last	ADJ
dti-1304	97	7	century	century	NOUN
dti-1304	97	8	,	,	PUNCT
dti-1304	97	9	it	it	PRON
dti-1304	97	10	was	be	AUX
dti-1304	97	11	reported	report	VERB
dti-1304	97	12	that	that	SCONJ
dti-1304	97	13	the	the	DET
dti-1304	97	14	inhibition	inhibition	NOUN
dti-1304	97	15	of	of	ADP
dti-1304	97	16	the	the	DET
dti-1304	97	17	autophosporylation	autophosporylation	NOUN
dti-1304	97	18	of	of	ADP
dti-1304	97	19	pdgf	pdgf	NOUN
dti-1304	97	20	-	-	PUNCT
dti-1304	97	21	r	r	NOUN
dti-1304	97	22	by	by	ADP
dti-1304	97	23	ag1296	ag1296	NOUN
dti-1304	97	24	effectively	effectively	ADV
dti-1304	97	25	prevented	prevent	VERB
dti-1304	97	26	v2o5stimulated	v2o5stimulate	VERB
dti-1304	97	27	proliferation	proliferation	NOUN
dti-1304	97	28	of	of	ADP
dti-1304	97	29	alveolar	alveolar	ADJ
dti-1304	97	30	epithelial/	epithelial/	NUM
dti-1304	97	31	mesenchymal	mesenchymal	NOUN
dti-1304	97	32	cells	cell	NOUN
dti-1304	97	33	as	as	ADV
dti-1304	97	34	well	well	ADV
dti-1304	97	35	as	as	ADP
dti-1304	97	36	hydroxyproline	hydroxyproline	ADJ
dti-1304	97	37	accumulation	accumulation	NOUN
dti-1304	97	38	[	[	X
dti-1304	97	39	rice	rice	NOUN
dti-1304	97	40	et	et	PROPN
dti-1304	97	41	al	al	PROPN
dti-1304	97	42	.	.	PROPN
dti-1304	97	43	1999	1999	NUM
dti-1304	97	44	]	]	PUNCT
dti-1304	97	45	.	.	PUNCT
dti-1304	98	1	in	in	ADP
dti-1304	98	2	that	that	DET
dti-1304	98	3	model	model	NOUN
dti-1304	98	4	,	,	PUNCT
dti-1304	98	5	a	a	DET
dti-1304	98	6	specific	specific	ADJ
dti-1304	98	7	inhibition	inhibition	NOUN
dti-1304	98	8	of	of	ADP
dti-1304	98	9	epidermal	epidermal	ADJ
dti-1304	98	10	growth	growth	NOUN
dti-1304	98	11	factor	factor	NOUN
dti-1304	98	12	(	(	PUNCT
dti-1304	98	13	egf	egf	NOUN
dti-1304	98	14	)	)	PUNCT
dti-1304	98	15	receptor	receptor	NOUN
dti-1304	98	16	activation	activation	NOUN
dti-1304	98	17	by	by	ADP
dti-1304	98	18	ag1478	ag1478	PROPN
dti-1304	98	19	also	also	ADV
dti-1304	98	20	showed	show	VERB
dti-1304	98	21	a	a	DET
dti-1304	98	22	preventive	preventive	ADJ
dti-1304	98	23	efficacy	efficacy	NOUN
dti-1304	98	24	,	,	PUNCT
dti-1304	98	25	although	although	SCONJ
dti-1304	98	26	slightly	slightly	ADV
dti-1304	98	27	less	less	ADV
dti-1304	98	28	compared	compare	VERB
dti-1304	98	29	to	to	ADP
dti-1304	98	30	ag1296	ag1296	PROPN
dti-1304	98	31	.	.	PUNCT
dti-1304	99	1	another	another	DET
dti-1304	99	2	approach	approach	NOUN
dti-1304	99	3	using	use	VERB
dti-1304	99	4	an	an	DET
dti-1304	99	5	expression	expression	NOUN
dti-1304	99	6	plasmid	plasmid	NOUN
dti-1304	99	7	of	of	ADP
dti-1304	99	8	the	the	DET
dti-1304	99	9	extracellular	extracellular	ADJ
dti-1304	99	10	domain	domain	NOUN
dti-1304	99	11	of	of	ADP
dti-1304	99	12	pdgf	pdgf	NOUN
dti-1304	99	13	-	-	PUNCT
dti-1304	99	14	rβ	rβ	NOUN
dti-1304	99	15	for	for	ADP
dti-1304	99	16	bleomycin	bleomycin	PROPN
dti-1304	99	17	-	-	PUNCT
dti-1304	99	18	treated	treat	VERB
dti-1304	99	19	c57bl/6	c57bl/6	NOUN
dti-1304	99	20	mice	mouse	NOUN
dti-1304	99	21	also	also	ADV
dti-1304	99	22	ameliorated	ameliorate	VERB
dti-1304	99	23	the	the	DET
dti-1304	99	24	increases	increase	NOUN
dti-1304	99	25	in	in	ADP
dti-1304	99	26	the	the	DET
dti-1304	99	27	wet	wet	ADJ
dti-1304	99	28	weight	weight	NOUN
dti-1304	99	29	,	,	PUNCT
dti-1304	99	30	hydroxyproline	hydroxyproline	PROPN
dti-1304	99	31	content	content	NOUN
dti-1304	99	32	and	and	CCONJ
dti-1304	99	33	the	the	DET
dti-1304	99	34	histologic	histologic	ADJ
dti-1304	99	35	changes	change	NOUN
dti-1304	99	36	in	in	ADP
dti-1304	99	37	the	the	DET
dti-1304	99	38	lung	lung	NOUN
dti-1304	100	1	[	[	X
dti-1304	100	2	yoshida	yoshida	PROPN
dti-1304	100	3	et	et	PROPN
dti-1304	100	4	al	al	PROPN
dti-1304	100	5	.	.	PROPN
dti-1304	100	6	1999	1999	NUM
dti-1304	100	7	]	]	PUNCT
dti-1304	100	8	.	.	PUNCT
dti-1304	101	1	daniel	daniel	PROPN
dti-1304	101	2	et	et	PROPN
dti-1304	101	3	al	al	PROPN
dti-1304	101	4	.	.	PROPN
dti-1304	101	5	proved	prove	VERB
dti-1304	101	6	that	that	SCONJ
dti-1304	101	7	imatinib	imatinib	NOUN
dti-1304	101	8	dramatically	dramatically	ADV
dti-1304	101	9	reduced	reduce	VERB
dti-1304	101	10	hydroxyproline	hydroxyproline	PROPN
dti-1304	101	11	content	content	NOUN
dti-1304	101	12	and	and	CCONJ
dti-1304	101	13	prevented	prevent	VERB
dti-1304	101	14	243	243	NUM
dti-1304	101	15	pdgf	pdgf	NOUN
dti-1304	101	16	as	as	ADP
dti-1304	101	17	a	a	DET
dti-1304	101	18	target	target	NOUN
dti-1304	101	19	for	for	ADP
dti-1304	101	20	systemic	systemic	ADJ
dti-1304	101	21	autoimmune	autoimmune	ADJ
dti-1304	101	22	diseases	disease	NOUN
dti-1304	101	23	drug	drug	NOUN
dti-1304	101	24	target	target	NOUN
dti-1304	101	25	insights	insight	VERB
dti-1304	101	26	2007:2	2007:2	NUM
dti-1304	101	27	histopathologic	histopathologic	ADJ
dti-1304	101	28	changes	change	NOUN
dti-1304	101	29	in	in	ADP
dti-1304	101	30	bleomycin	bleomycin	NOUN
dti-1304	101	31	-	-	PUNCT
dti-1304	101	32	treated	treat	VERB
dti-1304	101	33	lungs	lung	NOUN
dti-1304	101	34	of	of	ADP
dti-1304	101	35	129tsvems	129tsvems	PROPN
dti-1304	101	36	mice	mouse	NOUN
dti-1304	102	1	[	[	X
dti-1304	102	2	daniel	daniel	PROPN
dti-1304	102	3	et	et	PROPN
dti-1304	102	4	al	al	PROPN
dti-1304	102	5	.	.	PROPN
dti-1304	102	6	2004	2004	NUM
dti-1304	102	7	]	]	PUNCT
dti-1304	102	8	.	.	PUNCT
dti-1304	103	1	they	they	PRON
dti-1304	103	2	also	also	ADV
dti-1304	103	3	suggested	suggest	VERB
dti-1304	103	4	that	that	SCONJ
dti-1304	103	5	the	the	DET
dti-1304	103	6	effi	effi	PROPN
dti-1304	103	7	cacy	cacy	NOUN
dti-1304	103	8	of	of	ADP
dti-1304	103	9	imatinib	imatinib	NOUN
dti-1304	103	10	is	be	AUX
dti-1304	103	11	mediated	mediate	VERB
dti-1304	103	12	,	,	PUNCT
dti-1304	103	13	in	in	ADP
dti-1304	103	14	part	part	NOUN
dti-1304	103	15	,	,	PUNCT
dti-1304	103	16	by	by	ADP
dti-1304	103	17	the	the	DET
dti-1304	103	18	inhibition	inhibition	NOUN
dti-1304	103	19	of	of	ADP
dti-1304	103	20	serine	serine	NOUN
dti-1304	103	21	/	/	SYM
dti-1304	103	22	threonine	threonine	NOUN
dti-1304	103	23	tgf	tgf	PROPN
dti-1304	103	24	-	-	PUNCT
dti-1304	103	25	β	β	PROPN
dti-1304	103	26	receptor	receptor	NOUN
dti-1304	103	27	kinase	kinase	NOUN
dti-1304	103	28	signaling	signal	VERB
dti-1304	103	29	through	through	ADP
dti-1304	103	30	c	c	PROPN
dti-1304	103	31	-	-	PUNCT
dti-1304	103	32	abl	abl	PROPN
dti-1304	103	33	tyrosine	tyrosine	PROPN
dti-1304	103	34	kinase	kinase	PROPN
dti-1304	103	35	.	.	PUNCT
dti-1304	104	1	aono	aono	PROPN
dti-1304	104	2	et	et	PROPN
dti-1304	104	3	al	al	PROPN
dti-1304	104	4	.	.	PROPN
dti-1304	104	5	also	also	ADV
dti-1304	104	6	showed	show	VERB
dti-1304	104	7	that	that	SCONJ
dti-1304	104	8	imatinib	imatinib	NOUN
dti-1304	104	9	(	(	PUNCT
dti-1304	104	10	50	50	NUM
dti-1304	104	11	mg	mg	PROPN
dti-1304	104	12	/	/	SYM
dti-1304	104	13	kg	kg	NOUN
dti-1304	104	14	)	)	PUNCT
dti-1304	104	15	signifi	signifi	NOUN
dti-1304	104	16	cantly	cantly	ADV
dti-1304	104	17	attenuated	attenuate	VERB
dti-1304	104	18	bleomycin	bleomycin	NOUN
dti-1304	104	19	-	-	PUNCT
dti-1304	104	20	induced	induce	VERB
dti-1304	104	21	pulmonary	pulmonary	ADJ
dti-1304	104	22	fi	fi	NOUN
dti-1304	104	23	brosis	brosis	NOUN
dti-1304	104	24	in	in	ADP
dti-1304	104	25	terms	term	NOUN
dti-1304	104	26	of	of	ADP
dti-1304	104	27	histology	histology	NOUN
dti-1304	104	28	and	and	CCONJ
dti-1304	104	29	collagen	collagen	NOUN
dti-1304	104	30	deposition	deposition	NOUN
dti-1304	104	31	in	in	ADP
dti-1304	104	32	c57bl/6	c57bl/6	NOUN
dti-1304	104	33	mice	mouse	NOUN
dti-1304	104	34	.	.	PUNCT
dti-1304	105	1	interestingly	interestingly	ADV
dti-1304	105	2	,	,	PUNCT
dti-1304	105	3	the	the	DET
dti-1304	105	4	early	early	ADJ
dti-1304	105	5	treatment	treatment	NOUN
dti-1304	105	6	with	with	ADP
dti-1304	105	7	imatinib	imatinib	NOUN
dti-1304	105	8	(	(	PUNCT
dti-1304	105	9	from	from	ADP
dti-1304	105	10	day	day	NOUN
dti-1304	105	11	0	0	NUM
dti-1304	105	12	to	to	ADP
dti-1304	105	13	14	14	NUM
dti-1304	105	14	)	)	PUNCT
dti-1304	105	15	,	,	PUNCT
dti-1304	105	16	but	but	CCONJ
dti-1304	105	17	not	not	PART
dti-1304	105	18	the	the	DET
dti-1304	105	19	late	late	ADJ
dti-1304	105	20	treatment	treatment	NOUN
dti-1304	105	21	(	(	PUNCT
dti-1304	105	22	from	from	ADP
dti-1304	105	23	day	day	NOUN
dti-1304	105	24	15	15	NUM
dti-1304	105	25	to	to	PART
dti-1304	105	26	28	28	NUM
dti-1304	105	27	)	)	PUNCT
dti-1304	105	28	significantly	significantly	ADV
dti-1304	105	29	inhibited	inhibit	VERB
dti-1304	105	30	bleomycin	bleomycin	PROPN
dti-1304	105	31	-	-	PUNCT
dti-1304	105	32	induced	induce	VERB
dti-1304	105	33	lung	lung	NOUN
dti-1304	105	34	fi	fi	NOUN
dti-1304	105	35	brosis	brosis	NOUN
dti-1304	105	36	in	in	ADP
dti-1304	105	37	that	that	DET
dti-1304	105	38	model	model	NOUN
dti-1304	106	1	[	[	X
dti-1304	106	2	aono	aono	X
dti-1304	106	3	et	et	PROPN
dti-1304	106	4	al	al	PROPN
dti-1304	106	5	.	.	PROPN
dti-1304	106	6	2005	2005	NUM
dti-1304	106	7	]	]	PUNCT
dti-1304	106	8	.	.	PUNCT
dti-1304	107	1	however	however	ADV
dti-1304	107	2	,	,	PUNCT
dti-1304	107	3	another	another	DET
dti-1304	107	4	bleomycininduced	bleomycininduced	ADJ
dti-1304	107	5	lung	lung	NOUN
dti-1304	107	6	fi	fi	NOUN
dti-1304	107	7	brosis	brosis	NOUN
dti-1304	107	8	model	model	NOUN
dti-1304	107	9	using	use	VERB
dti-1304	107	10	rats	rat	NOUN
dti-1304	107	11	showed	show	VERB
dti-1304	107	12	that	that	SCONJ
dti-1304	107	13	imatinib	imatinib	NOUN
dti-1304	107	14	(	(	PUNCT
dti-1304	107	15	50	50	NUM
dti-1304	107	16	mg	mg	PROPN
dti-1304	107	17	/	/	SYM
dti-1304	107	18	kg	kg	NOUN
dti-1304	107	19	)	)	PUNCT
dti-1304	107	20	treatment	treatment	NOUN
dti-1304	107	21	commenced	commence	VERB
dti-1304	107	22	at	at	ADP
dti-1304	107	23	day	day	NOUN
dti-1304	107	24	10	10	NUM
dti-1304	107	25	was	be	AUX
dti-1304	107	26	still	still	ADV
dti-1304	107	27	effective	effective	ADJ
dti-1304	107	28	,	,	PUNCT
dti-1304	107	29	while	while	SCONJ
dti-1304	107	30	prednisolone	prednisolone	PROPN
dti-1304	107	31	was	be	AUX
dti-1304	107	32	effective	effective	ADJ
dti-1304	107	33	exclusively	exclusively	ADV
dti-1304	107	34	in	in	ADP
dti-1304	107	35	the	the	DET
dti-1304	107	36	preventive	preventive	ADJ
dti-1304	107	37	model	model	NOUN
dti-1304	107	38	started	start	VERB
dti-1304	107	39	at	at	ADP
dti-1304	107	40	day	day	NOUN
dti-1304	107	41	1	1	NUM
dti-1304	108	1	[	[	X
dti-1304	108	2	chaudhary	chaudhary	PROPN
dti-1304	108	3	et	et	PROPN
dti-1304	108	4	al	al	PROPN
dti-1304	108	5	.	.	PROPN
dti-1304	108	6	2006	2006	NUM
dti-1304	108	7	]	]	PUNCT
dti-1304	108	8	.	.	PUNCT
dti-1304	109	1	in	in	ADP
dti-1304	109	2	the	the	DET
dti-1304	109	3	radiation	radiation	NOUN
dti-1304	109	4	(	(	PUNCT
dti-1304	109	5	20	20	NUM
dti-1304	109	6	gy)-induced	gy)-induce	VERB
dti-1304	109	7	lung	lung	NOUN
dti-1304	109	8	fi	fi	NOUN
dti-1304	109	9	brosis	brosis	NOUN
dti-1304	109	10	model	model	NOUN
dti-1304	109	11	using	use	VERB
dti-1304	109	12	c57bl/6	c57bl/6	NOUN
dti-1304	109	13	mice	mouse	NOUN
dti-1304	109	14	,	,	PUNCT
dti-1304	109	15	treatment	treatment	NOUN
dti-1304	109	16	with	with	ADP
dti-1304	109	17	either	either	PRON
dti-1304	109	18	of	of	ADP
dti-1304	109	19	3	3	NUM
dti-1304	109	20	pdgf	pdgf	ADJ
dti-1304	109	21	-	-	PUNCT
dti-1304	109	22	r	r	NOUN
dti-1304	109	23	inhibitors	inhibitor	NOUN
dti-1304	109	24	(	(	PUNCT
dti-1304	109	25	su9518	su9518	PROPN
dti-1304	109	26	,	,	PUNCT
dti-1304	109	27	su11657	su11657	PROPN
dti-1304	109	28	and	and	CCONJ
dti-1304	109	29	imatinib	imatinib	NOUN
dti-1304	109	30	)	)	PUNCT
dti-1304	109	31	markedly	markedly	ADV
dti-1304	109	32	attenuated	attenuate	VERB
dti-1304	109	33	the	the	DET
dti-1304	109	34	development	development	NOUN
dti-1304	109	35	of	of	ADP
dti-1304	109	36	pulmonary	pulmonary	ADJ
dti-1304	109	37	fi	fi	NOUN
dti-1304	109	38	brosis	brosis	NOUN
dti-1304	109	39	in	in	ADP
dti-1304	109	40	excellent	excellent	ADJ
dti-1304	109	41	correlation	correlation	NOUN
dti-1304	109	42	with	with	ADP
dti-1304	109	43	clinical	clinical	ADJ
dti-1304	109	44	,	,	PUNCT
dti-1304	109	45	histological	histological	ADJ
dti-1304	109	46	,	,	PUNCT
dti-1304	109	47	ct	ct	PROPN
dti-1304	109	48	results	result	NOUN
dti-1304	109	49	,	,	PUNCT
dti-1304	109	50	and	and	CCONJ
dti-1304	109	51	life	life	NOUN
dti-1304	109	52	span	span	NOUN
dti-1304	109	53	.	.	PUNCT
dti-1304	110	1	in	in	ADP
dti-1304	110	2	addition	addition	NOUN
dti-1304	110	3	,	,	PUNCT
dti-1304	110	4	no	no	DET
dti-1304	110	5	decline	decline	NOUN
dti-1304	110	6	in	in	ADP
dti-1304	110	7	their	their	PRON
dti-1304	110	8	effi	effi	PROPN
dti-1304	110	9	cacy	cacy	NOUN
dti-1304	110	10	was	be	AUX
dti-1304	110	11	observed	observe	VERB
dti-1304	110	12	when	when	SCONJ
dti-1304	110	13	they	they	PRON
dti-1304	110	14	were	be	AUX
dti-1304	110	15	started	start	VERB
dti-1304	110	16	after	after	ADP
dti-1304	110	17	thoracic	thoracic	NOUN
dti-1304	110	18	irradiation	irradiation	NOUN
dti-1304	110	19	compared	compare	VERB
dti-1304	110	20	to	to	ADP
dti-1304	110	21	a	a	DET
dti-1304	110	22	prevention	prevention	NOUN
dti-1304	110	23	schedule	schedule	NOUN
dti-1304	110	24	[	[	X
dti-1304	110	25	abdollahi	abdollahi	NOUN
dti-1304	110	26	et	et	PROPN
dti-1304	110	27	al	al	PROPN
dti-1304	110	28	.	.	PROPN
dti-1304	110	29	2005	2005	NUM
dti-1304	110	30	]	]	PUNCT
dti-1304	110	31	.	.	PUNCT
dti-1304	111	1	these	these	DET
dti-1304	111	2	results	result	NOUN
dti-1304	111	3	may	may	AUX
dti-1304	111	4	provide	provide	VERB
dti-1304	111	5	a	a	DET
dti-1304	111	6	possibility	possibility	NOUN
dti-1304	111	7	that	that	SCONJ
dti-1304	111	8	imatinib	imatinib	NOUN
dti-1304	111	9	could	could	AUX
dti-1304	111	10	be	be	AUX
dti-1304	111	11	chosen	choose	VERB
dti-1304	111	12	for	for	ADP
dti-1304	111	13	the	the	DET
dti-1304	111	14	treatment	treatment	NOUN
dti-1304	111	15	of	of	ADP
dti-1304	111	16	corticosteroid(/immunosuppresants)-refractory	corticosteroid(/immunosuppresants)-refractory	ADJ
dti-1304	111	17	ild	ild	NOUN
dti-1304	111	18	.	.	PUNCT
dti-1304	112	1	in	in	ADP
dti-1304	112	2	contrast	contrast	NOUN
dti-1304	112	3	to	to	ADP
dti-1304	112	4	the	the	DET
dti-1304	112	5	above	above	NOUN
dti-1304	112	6	,	,	PUNCT
dti-1304	112	7	a	a	DET
dti-1304	112	8	recent	recent	ADJ
dti-1304	112	9	report	report	NOUN
dti-1304	112	10	failed	fail	VERB
dti-1304	112	11	to	to	PART
dti-1304	112	12	demonstrate	demonstrate	VERB
dti-1304	112	13	the	the	DET
dti-1304	112	14	effi	effi	PROPN
dti-1304	112	15	cacy	cacy	NOUN
dti-1304	112	16	of	of	ADP
dti-1304	112	17	imatinib	imatinib	NOUN
dti-1304	112	18	(	(	PUNCT
dti-1304	112	19	10	10	NUM
dti-1304	112	20	mg	mg	NUM
dti-1304	112	21	/	/	SYM
dti-1304	112	22	kg	kg	PROPN
dti-1304	112	23	,	,	PUNCT
dti-1304	112	24	intraperitoneal	intraperitoneal	ADJ
dti-1304	112	25	or	or	CCONJ
dti-1304	112	26	oral	oral	ADJ
dti-1304	112	27	administration	administration	NOUN
dti-1304	112	28	)	)	PUNCT
dti-1304	112	29	in	in	ADP
dti-1304	112	30	the	the	DET
dti-1304	112	31	protection	protection	NOUN
dti-1304	112	32	against	against	ADP
dti-1304	112	33	bleomycin	bleomycin	NOUN
dti-1304	112	34	-	-	PUNCT
dti-1304	112	35	induced	induce	VERB
dti-1304	112	36	pulmonary	pulmonary	ADJ
dti-1304	112	37	fi	fi	NOUN
dti-1304	112	38	brosis	brosis	NOUN
dti-1304	112	39	in	in	ADP
dti-1304	112	40	c57bl/6	c57bl/6	NOUN
dti-1304	112	41	mice	mouse	NOUN
dti-1304	113	1	[	[	X
dti-1304	113	2	vittal	vittal	NOUN
dti-1304	113	3	et	et	PROPN
dti-1304	113	4	al	al	PROPN
dti-1304	113	5	.	.	PROPN
dti-1304	113	6	2007	2007	NUM
dti-1304	113	7	]	]	PUNCT
dti-1304	113	8	.	.	PUNCT
dti-1304	114	1	lupus	lupus	ADJ
dti-1304	114	2	nephritis	nephritis	ADJ
dti-1304	114	3	systemic	systemic	ADJ
dti-1304	114	4	lupus	lupus	PROPN
dti-1304	114	5	erythematosus	erythematosus	NOUN
dti-1304	114	6	(	(	PUNCT
dti-1304	114	7	sle	sle	PROPN
dti-1304	114	8	)	)	PUNCT
dti-1304	114	9	is	be	AUX
dti-1304	114	10	a	a	DET
dti-1304	114	11	prototype	prototype	NOUN
dti-1304	114	12	of	of	ADP
dti-1304	114	13	systemic	systemic	ADJ
dti-1304	114	14	autoimmune	autoimmune	ADJ
dti-1304	114	15	diseases	disease	NOUN
dti-1304	114	16	and	and	CCONJ
dti-1304	114	17	its	its	PRON
dti-1304	114	18	renal	renal	ADJ
dti-1304	114	19	involvement	involvement	NOUN
dti-1304	114	20	has	have	AUX
dti-1304	114	21	been	be	AUX
dti-1304	114	22	posing	pose	VERB
dti-1304	114	23	major	major	ADJ
dti-1304	114	24	challenges	challenge	NOUN
dti-1304	114	25	for	for	ADP
dti-1304	114	26	physicians	physician	NOUN
dti-1304	114	27	.	.	PUNCT
dti-1304	115	1	renal	renal	ADJ
dti-1304	115	2	accumulation	accumulation	NOUN
dti-1304	115	3	of	of	ADP
dti-1304	115	4	immune	immune	ADJ
dti-1304	115	5	complexes	complex	NOUN
dti-1304	115	6	followed	follow	VERB
dti-1304	115	7	by	by	ADP
dti-1304	115	8	complement	complement	NOUN
dti-1304	115	9	activation	activation	NOUN
dti-1304	115	10	,	,	PUNCT
dti-1304	115	11	and	and	CCONJ
dti-1304	115	12	antibody	antibody	NOUN
dti-1304	115	13	-	-	PUNCT
dti-1304	115	14	effector	effector	NOUN
dti-1304	115	15	-	-	PUNCT
dti-1304	115	16	cell	cell	NOUN
dti-1304	115	17	interactions	interaction	NOUN
dti-1304	115	18	through	through	ADP
dti-1304	115	19	the	the	DET
dti-1304	115	20	fc	fc	PROPN
dti-1304	115	21	receptor	receptor	NOUN
dti-1304	115	22	have	have	AUX
dti-1304	115	23	been	be	AUX
dti-1304	115	24	implicated	implicate	VERB
dti-1304	115	25	in	in	ADP
dti-1304	115	26	the	the	DET
dti-1304	115	27	pathogenesis	pathogenesis	NOUN
dti-1304	115	28	of	of	ADP
dti-1304	115	29	lupus	lupus	PROPN
dti-1304	115	30	nephritis	nephritis	PROPN
dti-1304	115	31	.	.	PUNCT
dti-1304	116	1	high	high	ADJ
dti-1304	116	2	-	-	PUNCT
dti-1304	116	3	dose	dose	NOUN
dti-1304	116	4	corticosteroids	corticosteroid	NOUN
dti-1304	116	5	combined	combine	VERB
dti-1304	116	6	with	with	ADP
dti-1304	116	7	immunosuppressive	immunosuppressive	ADJ
dti-1304	116	8	agents	agent	NOUN
dti-1304	116	9	such	such	ADJ
dti-1304	116	10	as	as	ADP
dti-1304	116	11	cyclophosphamide	cyclophosphamide	NOUN
dti-1304	116	12	or	or	CCONJ
dti-1304	116	13	mycophenolate	mycophenolate	PROPN
dti-1304	116	14	mofetil	mofetil	NOUN
dti-1304	116	15	are	be	AUX
dti-1304	116	16	the	the	DET
dti-1304	116	17	mainstay	mainstay	NOUN
dti-1304	116	18	in	in	ADP
dti-1304	116	19	current	current	ADJ
dti-1304	116	20	strategy	strategy	NOUN
dti-1304	116	21	for	for	ADP
dti-1304	116	22	the	the	DET
dti-1304	116	23	induction	induction	NOUN
dti-1304	116	24	of	of	ADP
dti-1304	116	25	response	response	NOUN
dti-1304	116	26	in	in	ADP
dti-1304	116	27	lupus	lupus	ADJ
dti-1304	116	28	nephritis	nephritis	NOUN
dti-1304	116	29	.	.	PUNCT
dti-1304	117	1	some	some	DET
dti-1304	117	2	patients	patient	NOUN
dti-1304	117	3	however	however	ADV
dti-1304	117	4	do	do	AUX
dti-1304	117	5	not	not	PART
dti-1304	117	6	respond	respond	VERB
dti-1304	117	7	favorably	favorably	ADV
dti-1304	117	8	to	to	ADP
dti-1304	117	9	the	the	DET
dti-1304	117	10	above	above	ADJ
dti-1304	117	11	regimens	regimen	NOUN
dti-1304	117	12	or	or	CCONJ
dti-1304	117	13	show	show	VERB
dti-1304	117	14	repeated	repeat	VERB
dti-1304	117	15	relapses	relapse	NOUN
dti-1304	117	16	,	,	PUNCT
dti-1304	117	17	and	and	CCONJ
dti-1304	117	18	ultimately	ultimately	ADV
dti-1304	117	19	progress	progress	VERB
dti-1304	117	20	to	to	PART
dti-1304	117	21	end	end	VERB
dti-1304	117	22	-	-	PUNCT
dti-1304	117	23	stage	stage	NOUN
dti-1304	117	24	renal	renal	ADJ
dti-1304	117	25	disease	disease	NOUN
dti-1304	117	26	.	.	PUNCT
dti-1304	118	1	renal	renal	ADJ
dti-1304	118	2	expression	expression	NOUN
dti-1304	118	3	of	of	ADP
dti-1304	118	4	pdgf	pdgf	NOUN
dti-1304	118	5	,	,	PUNCT
dti-1304	118	6	which	which	PRON
dti-1304	118	7	is	be	AUX
dti-1304	118	8	synthesized	synthesize	VERB
dti-1304	118	9	by	by	ADP
dti-1304	118	10	mesangial	mesangial	ADJ
dti-1304	118	11	cells	cell	NOUN
dti-1304	118	12	,	,	PUNCT
dti-1304	118	13	endothelial	endothelial	ADJ
dti-1304	118	14	cells	cell	NOUN
dti-1304	118	15	,	,	PUNCT
dti-1304	118	16	macrophages	macrophage	NOUN
dti-1304	118	17	,	,	PUNCT
dti-1304	118	18	and	and	CCONJ
dti-1304	118	19	smooth	smooth	ADJ
dti-1304	118	20	muscle	muscle	NOUN
dti-1304	118	21	cells	cell	NOUN
dti-1304	118	22	in	in	ADP
dti-1304	118	23	the	the	DET
dti-1304	118	24	kidney	kidney	NOUN
dti-1304	118	25	,	,	PUNCT
dti-1304	118	26	and	and	CCONJ
dti-1304	118	27	of	of	ADP
dti-1304	118	28	pdgf	pdgf	NOUN
dti-1304	118	29	-	-	PUNCT
dti-1304	118	30	r	r	NOUN
dti-1304	118	31	was	be	AUX
dti-1304	118	32	signifi	signifi	NOUN
dti-1304	118	33	cantly	cantly	ADV
dti-1304	118	34	increased	increase	VERB
dti-1304	118	35	in	in	ADP
dti-1304	118	36	the	the	DET
dti-1304	118	37	glomeruli	glomeruli	NOUN
dti-1304	118	38	of	of	ADP
dti-1304	118	39	patients	patient	NOUN
dti-1304	118	40	with	with	ADP
dti-1304	118	41	mesangial	mesangial	ADJ
dti-1304	118	42	proliferative	proliferative	ADJ
dti-1304	118	43	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	118	44	(	(	PUNCT
dti-1304	118	45	iga	iga	PROPN
dti-1304	118	46	nephropathy	nephropathy	NOUN
dti-1304	118	47	,	,	PUNCT
dti-1304	118	48	henochschönlein	henochschönlein	NOUN
dti-1304	118	49	purpura	purpura	NOUN
dti-1304	118	50	nephritis	nephritis	PROPN
dti-1304	118	51	,	,	PUNCT
dti-1304	118	52	and	and	CCONJ
dti-1304	118	53	lupus	lupus	PROPN
dti-1304	118	54	nephritis	nephritis	NOUN
dti-1304	118	55	)	)	PUNCT
dti-1304	118	56	compared	compare	VERB
dti-1304	118	57	with	with	ADP
dti-1304	118	58	normal	normal	ADJ
dti-1304	118	59	glomeruli	glomerulus	NOUN
dti-1304	119	1	[	[	X
dti-1304	119	2	matsuda	matsuda	PROPN
dti-1304	119	3	et	et	PROPN
dti-1304	119	4	al	al	PROPN
dti-1304	119	5	.	.	PROPN
dti-1304	119	6	1997	1997	NUM
dti-1304	119	7	]	]	PUNCT
dti-1304	119	8	.	.	PUNCT
dti-1304	120	1	thus	thus	ADV
dti-1304	120	2	,	,	PUNCT
dti-1304	120	3	pdgf	pdgf	NOUN
dti-1304	120	4	/	/	SYM
dti-1304	120	5	pdgf	pdgf	NOUN
dti-1304	120	6	-	-	PUNCT
dti-1304	120	7	r	r	NOUN
dti-1304	120	8	axis	axis	NOUN
dti-1304	120	9	is	be	AUX
dti-1304	120	10	considered	consider	VERB
dti-1304	120	11	a	a	DET
dti-1304	120	12	novel	novel	ADJ
dti-1304	120	13	therapeutic	therapeutic	ADJ
dti-1304	120	14	target	target	NOUN
dti-1304	120	15	of	of	ADP
dti-1304	120	16	lupus	lupus	ADJ
dti-1304	120	17	nephritis	nephritis	NOUN
dti-1304	120	18	and	and	CCONJ
dti-1304	120	19	other	other	ADJ
dti-1304	120	20	forms	form	NOUN
dti-1304	120	21	of	of	ADP
dti-1304	120	22	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	120	23	.	.	PUNCT
dti-1304	121	1	indeed	indeed	ADV
dti-1304	121	2	,	,	PUNCT
dti-1304	121	3	administration	administration	NOUN
dti-1304	121	4	of	of	ADP
dti-1304	121	5	neutralizing	neutralize	VERB
dti-1304	121	6	anti	anti	ADJ
dti-1304	121	7	-	-	ADJ
dti-1304	121	8	pdgf	pdgf	ADJ
dti-1304	121	9	igg	igg	PROPN
dti-1304	122	1	[	[	X
dti-1304	122	2	johnson	johnson	PROPN
dti-1304	122	3	et	et	PROPN
dti-1304	122	4	al	al	PROPN
dti-1304	122	5	.	.	PROPN
dti-1304	122	6	1992	1992	NUM
dti-1304	122	7	]	]	PUNCT
dti-1304	122	8	or	or	CCONJ
dti-1304	122	9	oligonucleotide	oligonucleotide	VERB
dti-1304	122	10	aptamer	aptamer	NOUN
dti-1304	122	11	[	[	X
dti-1304	122	12	floege	floege	X
dti-1304	122	13	et	et	PROPN
dti-1304	122	14	al	al	PROPN
dti-1304	122	15	.	.	PROPN
dti-1304	122	16	1999	1999	NUM
dti-1304	122	17	]	]	PUNCT
dti-1304	122	18	,	,	PUNCT
dti-1304	122	19	which	which	PRON
dti-1304	122	20	specifi	specifi	PROPN
dti-1304	122	21	cally	cally	ADV
dti-1304	122	22	binds	bind	VERB
dti-1304	122	23	to	to	ADP
dti-1304	122	24	the	the	DET
dti-1304	122	25	pdgf	pdgf	ADJ
dti-1304	122	26	-	-	PUNCT
dti-1304	122	27	b	b	NOUN
dti-1304	122	28	chain	chain	NOUN
dti-1304	122	29	and	and	CCONJ
dti-1304	122	30	inhibits	inhibit	VERB
dti-1304	122	31	its	its	PRON
dti-1304	122	32	activity	activity	NOUN
dti-1304	122	33	to	to	ADP
dti-1304	122	34	anti	anti	ADJ
dti-1304	122	35	-	-	ADJ
dti-1304	122	36	thy-1	thy-1	ADJ
dti-1304	122	37	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	122	38	rats	rat	NOUN
dti-1304	122	39	resulted	result	VERB
dti-1304	122	40	in	in	ADP
dti-1304	122	41	a	a	DET
dti-1304	122	42	signifi	signifi	NOUN
dti-1304	122	43	ca	can	AUX
dti-1304	122	44	nt	not	PART
dti-1304	122	45	reduction	reduction	VERB
dti-1304	122	46	in	in	ADP
dti-1304	122	47	mesangial	mesangial	ADJ
dti-1304	122	48	cell	cell	NOUN
dti-1304	122	49	proliferation	proliferation	NOUN
dti-1304	122	50	and	and	CCONJ
dti-1304	122	51	largely	largely	ADV
dti-1304	122	52	prevented	prevent	VERB
dti-1304	122	53	the	the	DET
dti-1304	122	54	increased	increase	VERB
dti-1304	122	55	deposition	deposition	NOUN
dti-1304	122	56	of	of	ADP
dti-1304	122	57	ecm	ecm	NOUN
dti-1304	122	58	.	.	PUNCT
dti-1304	123	1	imatinib	imatinib	NOUN
dti-1304	123	2	(	(	PUNCT
dti-1304	123	3	0.013–2.0	0.013–2.0	NOUN
dti-1304	123	4	µm	µm	NOUN
dti-1304	123	5	)	)	PUNCT
dti-1304	123	6	inhibited	inhibited	ADJ
dti-1304	123	7	pdgfstimulated	pdgfstimulate	VERB
dti-1304	123	8	,	,	PUNCT
dti-1304	123	9	but	but	CCONJ
dti-1304	123	10	not	not	PART
dti-1304	123	11	fgf	fgf	NOUN
dti-1304	123	12	-	-	PUNCT
dti-1304	123	13	stimulated	stimulate	VERB
dti-1304	123	14	,	,	PUNCT
dti-1304	123	15	mesangial	mesangial	ADJ
dti-1304	123	16	cell	cell	NOUN
dti-1304	123	17	proliferation	proliferation	NOUN
dti-1304	123	18	in	in	ADP
dti-1304	123	19	a	a	DET
dti-1304	123	20	dose	dose	NOUN
dti-1304	123	21	-	-	PUNCT
dti-1304	123	22	dependent	dependent	ADJ
dti-1304	123	23	fashion	fashion	NOUN
dti-1304	123	24	in	in	ADP
dti-1304	123	25	vitro	vitro	X
dti-1304	124	1	[	[	X
dti-1304	124	2	gilbert	gilbert	X
dti-1304	124	3	et	et	PROPN
dti-1304	124	4	al	al	PROPN
dti-1304	124	5	.	.	PROPN
dti-1304	124	6	2001	2001	NUM
dti-1304	124	7	]	]	PUNCT
dti-1304	124	8	.	.	PUNCT
dti-1304	125	1	moreover	moreover	ADV
dti-1304	125	2	,	,	PUNCT
dti-1304	125	3	the	the	DET
dti-1304	125	4	effi	effi	PROPN
dti-1304	125	5	cacy	cacy	NOUN
dti-1304	125	6	of	of	ADP
dti-1304	125	7	imatinib	imatinib	NOUN
dti-1304	125	8	in	in	ADP
dti-1304	125	9	vivo	vivo	NOUN
dti-1304	125	10	has	have	AUX
dti-1304	125	11	been	be	AUX
dti-1304	125	12	proven	prove	VERB
dti-1304	125	13	in	in	ADP
dti-1304	125	14	3	3	NUM
dti-1304	125	15	different	different	ADJ
dti-1304	125	16	models	model	NOUN
dti-1304	125	17	of	of	ADP
dti-1304	125	18	(	(	PUNCT
dti-1304	125	19	lupus	lupus	NOUN
dti-1304	125	20	)	)	PUNCT
dti-1304	125	21	nephritis	nephritis	NOUN
dti-1304	125	22	.	.	PUNCT
dti-1304	126	1	first	first	ADV
dti-1304	126	2	,	,	PUNCT
dti-1304	126	3	pdgf	pdgf	ADJ
dti-1304	126	4	-	-	PUNCT
dti-1304	126	5	r	r	NOUN
dti-1304	126	6	tyrosine	tyrosine	NOUN
dti-1304	126	7	kinase	kinase	PROPN
dti-1304	126	8	blockade	blockade	NOUN
dti-1304	126	9	by	by	ADP
dti-1304	126	10	imatinib	imatinib	NOUN
dti-1304	126	11	(	(	PUNCT
dti-1304	126	12	50	50	NUM
dti-1304	126	13	mg	mg	PROPN
dti-1304	126	14	/	/	SYM
dti-1304	126	15	kg	kg	PROPN
dti-1304	126	16	/	/	SYM
dti-1304	126	17	day	day	NOUN
dti-1304	126	18	)	)	PUNCT
dti-1304	126	19	was	be	AUX
dti-1304	126	20	associated	associate	VERB
dti-1304	126	21	with	with	ADP
dti-1304	126	22	a	a	DET
dti-1304	126	23	signifi	signifi	NOUN
dti-1304	126	24	ca	can	AUX
dti-1304	126	25	nt	not	PART
dti-1304	126	26	reduction	reduction	VERB
dti-1304	126	27	in	in	ADP
dti-1304	126	28	mesangial	mesangial	ADJ
dti-1304	126	29	cell	cell	NOUN
dti-1304	126	30	proliferation	proliferation	NOUN
dti-1304	126	31	,	,	PUNCT
dti-1304	126	32	the	the	DET
dti-1304	126	33	number	number	NOUN
dti-1304	126	34	of	of	ADP
dti-1304	126	35	α	α	NOUN
dti-1304	126	36	-	-	PUNCT
dti-1304	126	37	sma	sma	NOUN
dti-1304	126	38	-	-	PUNCT
dti-1304	126	39	positive	positive	ADJ
dti-1304	126	40	mesangial	mesangial	ADJ
dti-1304	126	41	cells	cell	NOUN
dti-1304	126	42	,	,	PUNCT
dti-1304	126	43	and	and	CCONJ
dti-1304	126	44	glomerular	glomerular	ADJ
dti-1304	126	45	type	type	NOUN
dti-1304	126	46	iv	iv	NUM
dti-1304	126	47	collagen	collagen	NOUN
dti-1304	126	48	deposition	deposition	NOUN
dti-1304	126	49	in	in	ADP
dti-1304	126	50	male	male	ADJ
dti-1304	126	51	wistar	wistar	PROPN
dti-1304	126	52	rats	rat	NOUN
dti-1304	126	53	with	with	ADP
dti-1304	126	54	anti	anti	ADJ
dti-1304	126	55	-	-	ADJ
dti-1304	126	56	thy-1.1	thy-1.1	ADJ
dti-1304	126	57	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	127	1	[	[	X
dti-1304	127	2	gilbert	gilbert	PROPN
dti-1304	127	3	et	et	PROPN
dti-1304	127	4	al	al	PROPN
dti-1304	127	5	.	.	PROPN
dti-1304	127	6	2001	2001	NUM
dti-1304	127	7	]	]	PUNCT
dti-1304	127	8	.	.	PUNCT
dti-1304	128	1	second	second	ADJ
dti-1304	128	2	,	,	PUNCT
dti-1304	128	3	50	50	NUM
dti-1304	128	4	mg	mg	NOUN
dti-1304	128	5	/	/	SYM
dti-1304	128	6	kg	kg	PROPN
dti-1304	128	7	imatinib	imatinib	NOUN
dti-1304	128	8	inhibited	inhibit	VERB
dti-1304	128	9	proliferation	proliferation	NOUN
dti-1304	128	10	of	of	ADP
dti-1304	128	11	glomerular	glomerular	ADJ
dti-1304	128	12	cells	cell	NOUN
dti-1304	128	13	and	and	CCONJ
dti-1304	128	14	crescent	crescent	NOUN
dti-1304	128	15	formation	formation	NOUN
dti-1304	128	16	,	,	PUNCT
dti-1304	128	17	and	and	CCONJ
dti-1304	128	18	also	also	ADV
dti-1304	128	19	prolonged	prolong	VERB
dti-1304	128	20	the	the	DET
dti-1304	128	21	life	life	NOUN
dti-1304	128	22	span	span	NOUN
dti-1304	128	23	of	of	ADP
dti-1304	128	24	mrl	mrl	PROPN
dti-1304	128	25	/	/	SYM
dti-1304	128	26	lpr	lpr	PROPN
dti-1304	128	27	female	female	ADJ
dti-1304	128	28	mice	mouse	NOUN
dti-1304	129	1	[	[	X
dti-1304	129	2	sadanaga	sadanaga	NOUN
dti-1304	129	3	et	et	PROPN
dti-1304	129	4	al	al	PROPN
dti-1304	129	5	.	.	PROPN
dti-1304	129	6	2005	2005	NUM
dti-1304	129	7	]	]	PUNCT
dti-1304	129	8	.	.	PUNCT
dti-1304	130	1	intriguingly	intriguingly	ADV
dti-1304	130	2	,	,	PUNCT
dti-1304	130	3	attenuation	attenuation	NOUN
dti-1304	130	4	of	of	ADP
dti-1304	130	5	lymphadenopathy	lymphadenopathy	ADJ
dti-1304	130	6	and	and	CCONJ
dti-1304	130	7	salivary	salivary	ADJ
dti-1304	130	8	gland	gland	NOUN
dti-1304	130	9	infl	infl	PROPN
dti-1304	130	10	ammation	ammation	PROPN
dti-1304	130	11	,	,	PUNCT
dti-1304	130	12	as	as	ADV
dti-1304	130	13	well	well	ADV
dti-1304	130	14	as	as	ADP
dti-1304	130	15	reduction	reduction	NOUN
dti-1304	130	16	in	in	ADP
dti-1304	130	17	serum	serum	NOUN
dti-1304	130	18	anti	anti	ADJ
dti-1304	130	19	-	-	ADJ
dti-1304	130	20	doublestranded	doublestranded	ADJ
dti-1304	130	21	dna	dna	PROPN
dti-1304	130	22	antibodies	antibodie	VERB
dti-1304	130	23	,	,	PUNCT
dti-1304	130	24	was	be	AUX
dti-1304	130	25	also	also	ADV
dti-1304	130	26	observed	observe	VERB
dti-1304	130	27	in	in	ADP
dti-1304	130	28	the	the	DET
dti-1304	130	29	imatinib	imatinib	NOUN
dti-1304	130	30	-	-	PUNCT
dti-1304	130	31	treated	treat	VERB
dti-1304	130	32	mice	mouse	NOUN
dti-1304	130	33	.	.	PUNCT
dti-1304	131	1	third	third	ADJ
dti-1304	131	2	,	,	PUNCT
dti-1304	131	3	(	(	PUNCT
dti-1304	131	4	nzb	nzb	NOUN
dti-1304	131	5	/	/	SYM
dti-1304	131	6	w)f1	w)f1	PROPN
dti-1304	131	7	mice	mouse	NOUN
dti-1304	131	8	treated	treat	VERB
dti-1304	131	9	with	with	ADP
dti-1304	131	10	imatinib	imatinib	NOUN
dti-1304	131	11	(	(	PUNCT
dti-1304	131	12	50	50	NUM
dti-1304	131	13	mg	mg	NUM
dti-1304	131	14	/	/	SYM
dti-1304	131	15	kg	kg	NOUN
dti-1304	131	16	b.i.d./day	b.i.d./day	PROPN
dti-1304	131	17	)	)	PUNCT
dti-1304	131	18	showed	show	VERB
dti-1304	131	19	ameliorated	ameliorated	ADJ
dti-1304	131	20	survival	survival	NOUN
dti-1304	131	21	,	,	PUNCT
dti-1304	131	22	delayed	delay	VERB
dti-1304	131	23	onset	onset	NOUN
dti-1304	131	24	of	of	ADP
dti-1304	131	25	proteinuria	proteinuria	NOUN
dti-1304	131	26	,	,	PUNCT
dti-1304	131	27	and	and	CCONJ
dti-1304	131	28	preserved	preserve	VERB
dti-1304	131	29	renal	renal	ADJ
dti-1304	131	30	function	function	NOUN
dti-1304	132	1	[	[	X
dti-1304	132	2	zoja	zoja	X
dti-1304	132	3	et	et	NOUN
dti-1304	132	4	al	al	PROPN
dti-1304	132	5	.	.	PROPN
dti-1304	132	6	2006	2006	NUM
dti-1304	132	7	]	]	PUNCT
dti-1304	132	8	.	.	PUNCT
dti-1304	133	1	histologic	histologic	ADJ
dti-1304	133	2	examination	examination	NOUN
dti-1304	133	3	provided	provide	VERB
dti-1304	133	4	evidence	evidence	NOUN
dti-1304	133	5	of	of	ADP
dti-1304	133	6	reduced	reduce	VERB
dti-1304	133	7	glomerular	glomerular	ADJ
dti-1304	133	8	hypercellularity	hypercellularity	NOUN
dti-1304	133	9	,	,	PUNCT
dti-1304	133	10	deposits	deposit	NOUN
dti-1304	133	11	,	,	PUNCT
dti-1304	133	12	tubulointerstitial	tubulointerstitial	ADJ
dti-1304	133	13	damage	damage	NOUN
dti-1304	133	14	,	,	PUNCT
dti-1304	133	15	and	and	CCONJ
dti-1304	133	16	accumulation	accumulation	NOUN
dti-1304	133	17	of	of	ADP
dti-1304	133	18	α	α	NOUN
dti-1304	133	19	-	-	PUNCT
dti-1304	133	20	sma	sma	NOUN
dti-1304	133	21	-	-	PUNCT
dti-1304	133	22	positive	positive	ADJ
dti-1304	133	23	myofi	myofi	NOUN
dti-1304	133	24	broblasts	broblast	NOUN
dti-1304	133	25	.	.	PUNCT
dti-1304	134	1	rheumatoid	rheumatoid	VERB
dti-1304	134	2	arthritis	arthritis	NOUN
dti-1304	134	3	the	the	DET
dti-1304	134	4	synovial	synovial	ADJ
dti-1304	134	5	membrane	membrane	NOUN
dti-1304	134	6	in	in	ADP
dti-1304	134	7	patients	patient	NOUN
dti-1304	134	8	with	with	ADP
dti-1304	134	9	ra	ra	PROPN
dti-1304	134	10	is	be	AUX
dti-1304	134	11	characterized	characterize	VERB
dti-1304	134	12	by	by	ADP
dti-1304	134	13	hyperplasia	hyperplasia	NOUN
dti-1304	134	14	,	,	PUNCT
dti-1304	134	15	angiogenesis	angiogenesis	NOUN
dti-1304	134	16	,	,	PUNCT
dti-1304	134	17	and	and	CCONJ
dti-1304	134	18	an	an	DET
dti-1304	134	19	244	244	NUM
dti-1304	134	20	kameda	kameda	NOUN
dti-1304	134	21	et	et	PROPN
dti-1304	134	22	al	al	PROPN
dti-1304	134	23	drug	drug	PROPN
dti-1304	134	24	target	target	NOUN
dti-1304	134	25	insights	insight	NOUN
dti-1304	134	26	2007:2	2007:2	NUM
dti-1304	134	27	infi	infi	PROPN
dti-1304	134	28	ltrate	ltrate	NOUN
dti-1304	134	29	of	of	ADP
dti-1304	134	30	infl	infl	PROPN
dti-1304	134	31	ammatory	ammatory	NOUN
dti-1304	134	32	cells	cell	NOUN
dti-1304	134	33	including	include	VERB
dti-1304	134	34	cd4	cd4	PROPN
dti-1304	134	35	+	+	PROPN
dti-1304	134	36	t	t	NOUN
dti-1304	134	37	lymphocytes	lymphocyte	VERB
dti-1304	134	38	[	[	X
dti-1304	134	39	choy	choy	NOUN
dti-1304	134	40	and	and	CCONJ
dti-1304	134	41	panayi	panayi	NOUN
dti-1304	134	42	,	,	PUNCT
dti-1304	134	43	2001	2001	NUM
dti-1304	134	44	]	]	PUNCT
dti-1304	134	45	.	.	PUNCT
dti-1304	135	1	synovial	synovial	ADJ
dti-1304	135	2	fi	fi	NOUN
dti-1304	135	3	broblast	broblast	VERB
dti-1304	135	4	-	-	PUNCT
dti-1304	135	5	like	like	ADJ
dti-1304	135	6	(	(	PUNCT
dti-1304	135	7	sfl	sfl	PROPN
dti-1304	135	8	)	)	PUNCT
dti-1304	135	9	cells	cell	NOUN
dti-1304	135	10	from	from	ADP
dti-1304	135	11	ra	ra	PROPN
dti-1304	135	12	patients	patient	NOUN
dti-1304	135	13	show	show	VERB
dti-1304	135	14	transformed	transform	VERB
dti-1304	135	15	characteristics	characteristic	NOUN
dti-1304	135	16	[	[	X
dti-1304	135	17	firestein	firestein	ADJ
dti-1304	135	18	and	and	CCONJ
dti-1304	135	19	zvaifl	zvaifl	NOUN
dti-1304	135	20	er	er	INTJ
dti-1304	135	21	,	,	PUNCT
dti-1304	135	22	2002	2002	NUM
dti-1304	135	23	;	;	PUNCT
dti-1304	135	24	müller	müller	PROPN
dti-1304	135	25	-	-	PUNCT
dti-1304	135	26	ladner	ladner	PROPN
dti-1304	135	27	et	et	PROPN
dti-1304	135	28	al	al	PROPN
dti-1304	135	29	.	.	PROPN
dti-1304	135	30	2000	2000	NUM
dti-1304	135	31	;	;	PUNCT
dti-1304	135	32	yamanishi	yamanishi	NOUN
dti-1304	135	33	and	and	CCONJ
dti-1304	135	34	firestein	firestein	ADJ
dti-1304	135	35	,	,	PUNCT
dti-1304	135	36	2001	2001	NUM
dti-1304	135	37	]	]	SYM
dti-1304	135	38	:	:	PUNCT
dti-1304	135	39	altered	altered	ADJ
dti-1304	135	40	morphology	morphology	NOUN
dti-1304	135	41	,	,	PUNCT
dti-1304	135	42	anchorageindependent	anchorageindependent	ADJ
dti-1304	135	43	growth	growth	NOUN
dti-1304	136	1	[	[	X
dti-1304	136	2	lafyatis	lafyatis	NOUN
dti-1304	136	3	et	et	PROPN
dti-1304	136	4	al	al	PROPN
dti-1304	136	5	.	.	PROPN
dti-1304	136	6	1989	1989	NUM
dti-1304	136	7	]	]	PUNCT
dti-1304	136	8	,	,	PUNCT
dti-1304	136	9	loss	loss	NOUN
dti-1304	136	10	of	of	ADP
dti-1304	136	11	contact	contact	NOUN
dti-1304	136	12	inhibition	inhibition	NOUN
dti-1304	136	13	,	,	PUNCT
dti-1304	136	14	oncogene	oncogene	NOUN
dti-1304	136	15	activation	activation	NOUN
dti-1304	136	16	[	[	X
dti-1304	136	17	müllerladner	müllerladner	X
dti-1304	136	18	et	et	PROPN
dti-1304	136	19	al	al	PROPN
dti-1304	136	20	.	.	PROPN
dti-1304	136	21	1995	1995	NUM
dti-1304	136	22	]	]	PUNCT
dti-1304	136	23	,	,	PUNCT
dti-1304	136	24	monoclonal	monoclonal	NOUN
dti-1304	136	25	or	or	CCONJ
dti-1304	136	26	oligoclonal	oligoclonal	ADJ
dti-1304	136	27	expansion	expansion	NOUN
dti-1304	136	28	[	[	X
dti-1304	136	29	imamura	imamura	NOUN
dti-1304	136	30	et	et	PROPN
dti-1304	136	31	al	al	PROPN
dti-1304	136	32	.	.	PROPN
dti-1304	136	33	1998	1998	NUM
dti-1304	136	34	]	]	PUNCT
dti-1304	136	35	,	,	PUNCT
dti-1304	136	36	cartilage	cartilage	NOUN
dti-1304	136	37	invasion	invasion	NOUN
dti-1304	136	38	in	in	ADP
dti-1304	136	39	severe	severe	ADJ
dti-1304	136	40	combined	combine	VERB
dti-1304	136	41	immunodefi	immunodefi	NOUN
dti-1304	136	42	cient	cient	NOUN
dti-1304	136	43	mice	mouse	NOUN
dti-1304	137	1	[	[	X
dti-1304	137	2	müllerladner	müllerladner	X
dti-1304	137	3	et	et	PROPN
dti-1304	137	4	al	al	PROPN
dti-1304	137	5	.	.	PROPN
dti-1304	137	6	1996	1996	NUM
dti-1304	137	7	]	]	PUNCT
dti-1304	137	8	,	,	PUNCT
dti-1304	137	9	etc	etc	X
dti-1304	137	10	.	.	X
dti-1304	137	11	pdgf	pdgf	NOUN
dti-1304	137	12	-	-	PUNCT
dti-1304	137	13	rs	rs	NOUN
dti-1304	137	14	are	be	AUX
dti-1304	137	15	abundantly	abundantly	ADV
dti-1304	137	16	expressed	express	VERB
dti-1304	137	17	on	on	ADP
dti-1304	137	18	the	the	DET
dti-1304	137	19	surface	surface	NOUN
dti-1304	137	20	of	of	ADP
dti-1304	137	21	ra	ra	PROPN
dti-1304	137	22	-	-	PUNCT
dti-1304	137	23	sfl	sfl	PROPN
dti-1304	137	24	cells	cell	NOUN
dti-1304	137	25	,	,	PUNCT
dti-1304	137	26	and	and	CCONJ
dti-1304	137	27	stimulation	stimulation	NOUN
dti-1304	137	28	with	with	ADP
dti-1304	137	29	pdgf	pdgf	NOUN
dti-1304	137	30	enhances	enhance	NOUN
dti-1304	137	31	both	both	CCONJ
dti-1304	137	32	the	the	DET
dti-1304	137	33	anchorage	anchorage	NOUN
dti-1304	137	34	-	-	PUNCT
dti-1304	137	35	dependent	dependent	ADJ
dti-1304	137	36	and	and	CCONJ
dti-1304	137	37	-independent	-independent	ADJ
dti-1304	137	38	growth	growth	NOUN
dti-1304	137	39	of	of	ADP
dti-1304	137	40	ra	ra	PROPN
dti-1304	137	41	-	-	PUNCT
dti-1304	137	42	sfl	sfl	PROPN
dti-1304	137	43	cells	cell	NOUN
dti-1304	137	44	and	and	CCONJ
dti-1304	137	45	thus	thus	ADV
dti-1304	137	46	implicate	implicate	VERB
dti-1304	137	47	pdgf	pdgf	NOUN
dti-1304	137	48	in	in	ADP
dti-1304	137	49	the	the	DET
dti-1304	137	50	activation	activation	NOUN
dti-1304	137	51	and	and	CCONJ
dti-1304	137	52	transformation	transformation	NOUN
dti-1304	137	53	of	of	ADP
dti-1304	137	54	ra	ra	PROPN
dti-1304	137	55	-	-	PUNCT
dti-1304	137	56	sfl	sfl	PROPN
dti-1304	137	57	cells	cell	NOUN
dti-1304	138	1	[	[	X
dti-1304	138	2	lafyatis	lafyatis	NOUN
dti-1304	138	3	et	et	PROPN
dti-1304	138	4	al	al	PROPN
dti-1304	138	5	.	.	PROPN
dti-1304	138	6	1989	1989	NUM
dti-1304	138	7	;	;	PUNCT
dti-1304	138	8	rubin	rubin	PROPN
dti-1304	138	9	et	et	PROPN
dti-1304	138	10	al	al	PROPN
dti-1304	138	11	.	.	PROPN
dti-1304	138	12	1998	1998	NUM
dti-1304	138	13	;	;	PUNCT
dti-1304	138	14	remmers	remmer	NOUN
dti-1304	138	15	et	et	PROPN
dti-1304	138	16	al	al	PROPN
dti-1304	138	17	.	.	PROPN
dti-1304	138	18	1991	1991	NUM
dti-1304	138	19	;	;	PUNCT
dti-1304	138	20	sano	sano	PROPN
dti-1304	138	21	et	et	PROPN
dti-1304	138	22	al	al	PROPN
dti-1304	138	23	.	.	PROPN
dti-1304	138	24	1993	1993	NUM
dti-1304	138	25	;	;	PUNCT
dti-1304	138	26	watanabe	watanabe	PROPN
dti-1304	138	27	et	et	PROPN
dti-1304	138	28	al	al	PROPN
dti-1304	138	29	.	.	PROPN
dti-1304	138	30	]	]	PUNCT
dti-1304	138	31	.	.	PUNCT
dti-1304	139	1	indeed	indeed	ADV
dti-1304	139	2	,	,	PUNCT
dti-1304	139	3	pdgf	pdgf	PROPN
dti-1304	139	4	immunostaining	immunostaining	NOUN
dti-1304	139	5	of	of	ADP
dti-1304	139	6	ra	ra	PROPN
dti-1304	139	7	synovia	synovia	VERB
dti-1304	139	8	is	be	AUX
dti-1304	139	9	more	more	ADV
dti-1304	139	10	extensive	extensive	ADJ
dti-1304	139	11	and	and	CCONJ
dti-1304	139	12	intense	intense	ADJ
dti-1304	139	13	than	than	ADP
dti-1304	139	14	that	that	PRON
dti-1304	139	15	of	of	ADP
dti-1304	139	16	osteoarthritis	osteoarthritis	NOUN
dti-1304	139	17	(	(	PUNCT
dti-1304	139	18	oa	oa	NOUN
dti-1304	139	19	)	)	PUNCT
dti-1304	139	20	or	or	CCONJ
dti-1304	139	21	normal	normal	ADJ
dti-1304	139	22	synovia	synovia	NOUN
dti-1304	139	23	.	.	PUNCT
dti-1304	140	1	also	also	ADV
dti-1304	140	2	,	,	PUNCT
dti-1304	140	3	pdgf	pdgf	ADJ
dti-1304	140	4	-	-	PUNCT
dti-1304	140	5	r	r	NOUN
dti-1304	140	6	expression	expression	NOUN
dti-1304	140	7	is	be	AUX
dti-1304	140	8	elevated	elevate	VERB
dti-1304	140	9	in	in	ADP
dti-1304	140	10	ra	ra	PROPN
dti-1304	140	11	synovia	synovia	NOUN
dti-1304	140	12	compared	compare	VERB
dti-1304	140	13	with	with	ADP
dti-1304	140	14	oa	oa	PRON
dti-1304	140	15	and	and	CCONJ
dti-1304	140	16	normal	normal	ADJ
dti-1304	140	17	synovia	synovia	NOUN
dti-1304	141	1	[	[	X
dti-1304	141	2	remmers	remmer	NOUN
dti-1304	141	3	et	et	PROPN
dti-1304	141	4	al	al	PROPN
dti-1304	141	5	.	.	PROPN
dti-1304	141	6	1991	1991	NUM
dti-1304	141	7	]	]	PUNCT
dti-1304	141	8	.	.	PUNCT
dti-1304	142	1	moreover	moreover	ADV
dti-1304	142	2	,	,	PUNCT
dti-1304	142	3	pdgf	pdgf	NOUN
dti-1304	142	4	,	,	PUNCT
dti-1304	142	5	together	together	ADV
dti-1304	142	6	with	with	ADP
dti-1304	142	7	tnfα	tnfα	NOUN
dti-1304	142	8	,	,	PUNCT
dti-1304	142	9	were	be	AUX
dti-1304	142	10	identified	identify	VERB
dti-1304	142	11	as	as	ADP
dti-1304	142	12	the	the	DET
dti-1304	142	13	major	major	ADJ
dti-1304	142	14	growth	growth	NOUN
dti-1304	142	15	factors	factor	NOUN
dti-1304	142	16	of	of	ADP
dti-1304	142	17	ra	ra	PROPN
dti-1304	142	18	-	-	PUNCT
dti-1304	142	19	sfl	sfl	PROPN
dti-1304	142	20	cells	cell	NOUN
dti-1304	142	21	[	[	X
dti-1304	142	22	thornton	thornton	PROPN
dti-1304	142	23	et	et	PROPN
dti-1304	142	24	al	al	PROPN
dti-1304	142	25	.	.	PROPN
dti-1304	142	26	1991	1991	NUM
dti-1304	142	27	]	]	PUNCT
dti-1304	142	28	.	.	PUNCT
dti-1304	143	1	furthermore	furthermore	ADV
dti-1304	143	2	,	,	PUNCT
dti-1304	143	3	thrombin	thrombin	NOUN
dti-1304	143	4	activity	activity	NOUN
dti-1304	143	5	in	in	ADP
dti-1304	143	6	synovial	synovial	ADJ
dti-1304	143	7	fl	fl	PROPN
dti-1304	143	8	uid	uid	ADJ
dti-1304	143	9	is	be	AUX
dti-1304	143	10	signifi	signifi	NOUN
dti-1304	143	11	cantly	cantly	ADV
dti-1304	143	12	higher	high	ADJ
dti-1304	143	13	in	in	ADP
dti-1304	143	14	the	the	DET
dti-1304	143	15	patients	patient	NOUN
dti-1304	143	16	with	with	ADP
dti-1304	143	17	ra	ra	PROPN
dti-1304	143	18	than	than	ADP
dti-1304	143	19	with	with	ADP
dti-1304	143	20	oa	oa	NOUN
dti-1304	143	21	,	,	PUNCT
dti-1304	143	22	and	and	CCONJ
dti-1304	143	23	the	the	DET
dti-1304	143	24	mitogenic	mitogenic	ADJ
dti-1304	143	25	activity	activity	NOUN
dti-1304	143	26	of	of	ADP
dti-1304	143	27	thrombin	thrombin	NOUN
dti-1304	143	28	toward	toward	ADP
dti-1304	143	29	ra	ra	PROPN
dti-1304	143	30	-	-	PUNCT
dti-1304	143	31	sfl	sfl	PROPN
dti-1304	143	32	cells	cell	NOUN
dti-1304	143	33	is	be	AUX
dti-1304	143	34	associated	associate	VERB
dti-1304	143	35	with	with	ADP
dti-1304	143	36	an	an	DET
dti-1304	143	37	increase	increase	NOUN
dti-1304	143	38	in	in	ADP
dti-1304	143	39	the	the	DET
dti-1304	143	40	expression	expression	NOUN
dti-1304	143	41	of	of	ADP
dti-1304	143	42	mrna	mrna	PROPN
dti-1304	143	43	of	of	ADP
dti-1304	143	44	pdgf	pdgf	NOUN
dti-1304	143	45	-	-	PUNCT
dti-1304	143	46	rs	rs	NOUN
dti-1304	144	1	[	[	X
dti-1304	144	2	ohba	ohba	NOUN
dti-1304	144	3	et	et	PROPN
dti-1304	144	4	al	al	PROPN
dti-1304	144	5	.	.	PROPN
dti-1304	144	6	1996	1996	NUM
dti-1304	144	7	]	]	PUNCT
dti-1304	144	8	.	.	PUNCT
dti-1304	145	1	we	we	PRON
dti-1304	145	2	demonstrated	demonstrate	VERB
dti-1304	145	3	that	that	SCONJ
dti-1304	145	4	1	1	NUM
dti-1304	145	5	µm	µm	NOUN
dti-1304	145	6	of	of	ADP
dti-1304	145	7	imatinib	imatinib	NOUN
dti-1304	145	8	effectively	effectively	ADV
dti-1304	145	9	inhibited	inhibit	VERB
dti-1304	145	10	the	the	DET
dti-1304	145	11	pdgf	pdgf	NOUN
dti-1304	145	12	-	-	PUNCT
dti-1304	145	13	stimulated	stimulate	VERB
dti-1304	145	14	tyrosinephosphorylation	tyrosinephosphorylation	NOUN
dti-1304	145	15	of	of	ADP
dti-1304	145	16	pdgf	pdgf	NOUN
dti-1304	145	17	-	-	PUNCT
dti-1304	145	18	r	r	NOUN
dti-1304	145	19	in	in	ADP
dti-1304	145	20	ra	ra	PROPN
dti-1304	145	21	-	-	PUNCT
dti-1304	145	22	sfl	sfl	NOUN
dti-1304	145	23	cells	cell	NOUN
dti-1304	145	24	,	,	PUNCT
dti-1304	145	25	as	as	ADV
dti-1304	145	26	well	well	ADV
dti-1304	145	27	as	as	ADP
dti-1304	145	28	pdgf	pdgf	NOUN
dti-1304	145	29	-	-	PUNCT
dti-1304	145	30	enhanced	enhance	VERB
dti-1304	145	31	anchorage	anchorage	NOUN
dti-1304	145	32	-	-	PUNCT
dti-1304	145	33	dependent	dependent	ADJ
dti-1304	145	34	and	and	CCONJ
dti-1304	145	35	-independent	-independent	ADJ
dti-1304	145	36	ra	ra	NOUN
dti-1304	145	37	-	-	PUNCT
dti-1304	145	38	sfl	sfl	PROPN
dti-1304	145	39	cell	cell	NOUN
dti-1304	145	40	proliferation	proliferation	NOUN
dti-1304	145	41	in	in	ADP
dti-1304	145	42	vitro	vitro	X
dti-1304	146	1	[	[	PUNCT
dti-1304	146	2	kameda	kameda	X
dti-1304	146	3	et	et	PROPN
dti-1304	146	4	al	al	PROPN
dti-1304	146	5	.	.	PROPN
dti-1304	146	6	2006	2006	NUM
dti-1304	146	7	]	]	PUNCT
dti-1304	146	8	.	.	PUNCT
dti-1304	147	1	inhibition	inhibition	NOUN
dti-1304	147	2	of	of	ADP
dti-1304	147	3	pdgf	pdgf	ADJ
dti-1304	147	4	-	-	PUNCT
dti-1304	147	5	r	r	NOUN
dti-1304	147	6	signaling	signal	VERB
dti-1304	147	7	by	by	ADP
dti-1304	147	8	1	1	NUM
dti-1304	147	9	µm	µm	NOUN
dti-1304	147	10	of	of	ADP
dti-1304	147	11	imatinib	imatinib	NOUN
dti-1304	147	12	did	do	AUX
dti-1304	147	13	not	not	PART
dti-1304	147	14	induce	induce	VERB
dti-1304	147	15	apoptosis	apoptosis	NOUN
dti-1304	147	16	in	in	ADP
dti-1304	147	17	cultured	cultured	ADJ
dti-1304	147	18	ra	ra	PROPN
dti-1304	147	19	-	-	PUNCT
dti-1304	147	20	sfl	sfl	PROPN
dti-1304	147	21	cells	cell	NOUN
dti-1304	147	22	[	[	X
dti-1304	147	23	sandler	sandler	NOUN
dti-1304	147	24	et	et	PROPN
dti-1304	147	25	al	al	PROPN
dti-1304	147	26	.	.	PROPN
dti-1304	147	27	2006	2006	NUM
dti-1304	147	28	]	]	PUNCT
dti-1304	147	29	.	.	PUNCT
dti-1304	148	1	the	the	DET
dti-1304	148	2	effi	effi	PROPN
dti-1304	148	3	cacy	cacy	NOUN
dti-1304	148	4	of	of	ADP
dti-1304	148	5	imatinib	imatinib	NOUN
dti-1304	148	6	in	in	ADP
dti-1304	148	7	vivo	vivo	NOUN
dti-1304	148	8	has	have	AUX
dti-1304	148	9	been	be	AUX
dti-1304	148	10	almost	almost	ADV
dti-1304	148	11	simultaneously	simultaneously	ADV
dti-1304	148	12	reported	report	VERB
dti-1304	148	13	.	.	PUNCT
dti-1304	149	1	imatinib	imatinib	NOUN
dti-1304	149	2	(	(	PUNCT
dti-1304	149	3	33	33	NUM
dti-1304	149	4	–	–	SYM
dti-1304	149	5	100	100	NUM
dti-1304	149	6	mg	mg	NUM
dti-1304	149	7	/	/	SYM
dti-1304	149	8	kg	kg	NOUN
dti-1304	149	9	)	)	PUNCT
dti-1304	149	10	effectively	effectively	ADV
dti-1304	149	11	prevented	prevent	VERB
dti-1304	149	12	and	and	CCONJ
dti-1304	149	13	treated	treat	VERB
dti-1304	149	14	collagen	collagen	NOUN
dti-1304	149	15	-	-	PUNCT
dti-1304	149	16	induced	induce	VERB
dti-1304	149	17	arthritis	arthritis	NOUN
dti-1304	149	18	model	model	NOUN
dti-1304	149	19	of	of	ADP
dti-1304	149	20	dba/1	dba/1	PROPN
dti-1304	149	21	mice	mouse	NOUN
dti-1304	149	22	in	in	ADP
dti-1304	149	23	terms	term	NOUN
dti-1304	149	24	of	of	ADP
dti-1304	149	25	synovitis	synovitis	NOUN
dti-1304	149	26	,	,	PUNCT
dti-1304	149	27	pannus	pannus	ADJ
dti-1304	149	28	formation	formation	NOUN
dti-1304	149	29	and	and	CCONJ
dti-1304	149	30	joint	joint	ADJ
dti-1304	149	31	erosion	erosion	NOUN
dti-1304	149	32	,	,	PUNCT
dti-1304	149	33	although	although	SCONJ
dti-1304	149	34	preventive	preventive	ADJ
dti-1304	149	35	administration	administration	NOUN
dti-1304	149	36	was	be	AUX
dti-1304	149	37	more	more	ADV
dti-1304	149	38	effi	effi	PROPN
dti-1304	149	39	cacious	cacious	ADJ
dti-1304	149	40	than	than	ADP
dti-1304	149	41	therapeutic	therapeutic	ADJ
dti-1304	149	42	administration	administration	NOUN
dti-1304	150	1	[	[	X
dti-1304	150	2	paniagua	paniagua	X
dti-1304	150	3	et	et	VERB
dti-1304	150	4	al	al	PROPN
dti-1304	150	5	.	.	PROPN
dti-1304	150	6	2006	2006	NUM
dti-1304	150	7	]	]	PUNCT
dti-1304	150	8	.	.	PUNCT
dti-1304	151	1	notably	notably	ADV
dti-1304	151	2	,	,	PUNCT
dti-1304	151	3	imatinib	imatinib	NOUN
dti-1304	151	4	inhibited	inhibit	VERB
dti-1304	151	5	mast	mast	NOUN
dti-1304	151	6	cell	cell	NOUN
dti-1304	151	7	c	c	NOUN
dti-1304	151	8	-	-	PUNCT
dti-1304	151	9	kit	kit	NOUN
dti-1304	151	10	activation	activation	NOUN
dti-1304	151	11	,	,	PUNCT
dti-1304	151	12	proinflammatory	proinflammatory	ADJ
dti-1304	151	13	cytokine	cytokine	NOUN
dti-1304	151	14	production	production	NOUN
dti-1304	151	15	,	,	PUNCT
dti-1304	151	16	immunoglobulin	immunoglobulin	NOUN
dti-1304	151	17	production	production	NOUN
dti-1304	151	18	from	from	ADP
dti-1304	151	19	b	b	NOUN
dti-1304	151	20	cells	cell	NOUN
dti-1304	151	21	,	,	PUNCT
dti-1304	151	22	and	and	CCONJ
dti-1304	151	23	t	t	PROPN
dti-1304	151	24	cell	cell	NOUN
dti-1304	151	25	response	response	NOUN
dti-1304	151	26	.	.	PUNCT
dti-1304	152	1	however	however	ADV
dti-1304	152	2	,	,	PUNCT
dti-1304	152	3	collagen	collagen	NOUN
dti-1304	152	4	-	-	PUNCT
dti-1304	152	5	induced	induce	VERB
dti-1304	152	6	arthritis	arthritis	NOUN
dti-1304	152	7	in	in	ADP
dti-1304	152	8	lewis	lewis	PROPN
dti-1304	152	9	rats	rat	NOUN
dti-1304	152	10	were	be	AUX
dti-1304	152	11	resistant	resistant	ADJ
dti-1304	152	12	to	to	ADP
dti-1304	152	13	imatinib	imatinib	ADJ
dti-1304	152	14	treatment	treatment	NOUN
dti-1304	152	15	:	:	PUNCT
dti-1304	152	16	only	only	ADV
dti-1304	152	17	high	high	ADV
dti-1304	152	18	-	-	PUNCT
dti-1304	152	19	dose	dose	NOUN
dti-1304	152	20	(	(	PUNCT
dti-1304	152	21	150	150	NUM
dti-1304	152	22	mg	mg	PROPN
dti-1304	152	23	/	/	SYM
dti-1304	152	24	kg	kg	PROPN
dti-1304	152	25	,	,	PUNCT
dti-1304	152	26	not	not	PART
dti-1304	152	27	50	50	NUM
dti-1304	152	28	mg	mg	NUM
dti-1304	152	29	/	/	SYM
dti-1304	152	30	kg	kg	NOUN
dti-1304	152	31	)	)	PUNCT
dti-1304	152	32	imatinib	imatinib	NOUN
dti-1304	152	33	showed	show	VERB
dti-1304	152	34	a	a	DET
dti-1304	152	35	signifi	signifi	NOUN
dti-1304	152	36	ca	can	AUX
dti-1304	152	37	nt	not	PART
dti-1304	152	38	inhibition	inhibition	VERB
dti-1304	152	39	of	of	ADP
dti-1304	152	40	osteoclast	osteoclast	ADJ
dti-1304	152	41	formation	formation	NOUN
dti-1304	152	42	and	and	CCONJ
dti-1304	152	43	joint	joint	ADJ
dti-1304	152	44	destruction	destruction	NOUN
dti-1304	152	45	,	,	PUNCT
dti-1304	152	46	and	and	CCONJ
dti-1304	152	47	failed	fail	VERB
dti-1304	152	48	to	to	PART
dti-1304	152	49	reduce	reduce	VERB
dti-1304	152	50	paw	paw	NOUN
dti-1304	152	51	swelling	swelling	NOUN
dti-1304	152	52	[	[	X
dti-1304	152	53	ando	ando	X
dti-1304	152	54	et	et	PROPN
dti-1304	152	55	al	al	PROPN
dti-1304	152	56	.	.	PROPN
dti-1304	152	57	2006	2006	NUM
dti-1304	152	58	]	]	PUNCT
dti-1304	152	59	.	.	PUNCT
dti-1304	153	1	although	although	SCONJ
dti-1304	153	2	the	the	DET
dti-1304	153	3	downstream	downstream	ADJ
dti-1304	153	4	signaling	signal	VERB
dti-1304	153	5	pathway	pathway	NOUN
dti-1304	153	6	from	from	ADP
dti-1304	153	7	pdgf	pdgf	NOUN
dti-1304	153	8	-	-	PUNCT
dti-1304	153	9	r	r	NOUN
dti-1304	153	10	in	in	ADP
dti-1304	153	11	ra	ra	PROPN
dti-1304	153	12	-	-	ADJ
dti-1304	153	13	sfl	sfl	PROPN
dti-1304	153	14	cells	cell	NOUN
dti-1304	153	15	has	have	AUX
dti-1304	153	16	not	not	PART
dti-1304	153	17	been	be	AUX
dti-1304	153	18	clarifi	clarifi	NOUN
dti-1304	153	19	ed	ed	NOUN
dti-1304	153	20	,	,	PUNCT
dti-1304	153	21	many	many	ADJ
dti-1304	153	22	adaptor	adaptor	NOUN
dti-1304	153	23	proteins	protein	NOUN
dti-1304	153	24	are	be	AUX
dti-1304	153	25	likely	likely	ADJ
dti-1304	153	26	to	to	PART
dti-1304	153	27	be	be	AUX
dti-1304	153	28	involved	involve	VERB
dti-1304	153	29	.	.	PUNCT
dti-1304	154	1	for	for	ADP
dti-1304	154	2	example	example	NOUN
dti-1304	154	3	,	,	PUNCT
dti-1304	154	4	gab1	gab1	ADJ
dti-1304	154	5	and	and	CCONJ
dti-1304	154	6	gab2	gab2	PROPN
dti-1304	154	7	were	be	AUX
dti-1304	154	8	expressed	express	VERB
dti-1304	154	9	in	in	ADP
dti-1304	154	10	ra	ra	PROPN
dti-1304	154	11	-	-	PUNCT
dti-1304	154	12	sfl	sfl	NOUN
dti-1304	154	13	cells	cell	NOUN
dti-1304	154	14	,	,	PUNCT
dti-1304	154	15	and	and	CCONJ
dti-1304	154	16	both	both	DET
dti-1304	154	17	adaptor	adaptor	NOUN
dti-1304	154	18	proteins	protein	NOUN
dti-1304	154	19	were	be	AUX
dti-1304	154	20	rapidly	rapidly	ADV
dti-1304	154	21	tyrosine	tyrosine	NOUN
dti-1304	154	22	-	-	PUNCT
dti-1304	154	23	phosphorylated	phosphorylate	VERB
dti-1304	154	24	after	after	ADP
dti-1304	154	25	the	the	DET
dti-1304	154	26	stimulation	stimulation	NOUN
dti-1304	154	27	of	of	ADP
dti-1304	154	28	ra	ra	PROPN
dti-1304	154	29	-	-	PUNCT
dti-1304	154	30	sfl	sfl	PROPN
dti-1304	154	31	cells	cell	NOUN
dti-1304	154	32	with	with	ADP
dti-1304	154	33	10	10	NUM
dti-1304	154	34	ng	ng	PROPN
dti-1304	154	35	/	/	SYM
dti-1304	154	36	ml	ml	PROPN
dti-1304	154	37	of	of	ADP
dti-1304	154	38	pdgf	pdgf	PROPN
dti-1304	155	1	[	[	X
dti-1304	155	2	kameda	kameda	X
dti-1304	155	3	et	et	PROPN
dti-1304	155	4	al	al	PROPN
dti-1304	155	5	.	.	PROPN
dti-1304	155	6	2006	2006	NUM
dti-1304	155	7	]	]	PUNCT
dti-1304	155	8	.	.	PUNCT
dti-1304	156	1	the	the	DET
dti-1304	156	2	fact	fact	NOUN
dti-1304	156	3	that	that	SCONJ
dti-1304	156	4	the	the	DET
dti-1304	156	5	expression	expression	NOUN
dti-1304	156	6	of	of	ADP
dti-1304	156	7	gab1	gab1	ADV
dti-1304	156	8	lacking	lack	VERB
dti-1304	156	9	the	the	DET
dti-1304	156	10	pleckstrin	pleckstrin	PROPN
dti-1304	156	11	homology	homology	NOUN
dti-1304	156	12	domain	domain	NOUN
dti-1304	156	13	is	be	AUX
dti-1304	156	14	associated	associate	VERB
dti-1304	156	15	with	with	ADP
dti-1304	156	16	the	the	DET
dti-1304	156	17	enhanced	enhance	VERB
dti-1304	156	18	anchorage	anchorage	NOUN
dti-1304	156	19	-	-	PUNCT
dti-1304	156	20	independent	independent	ADJ
dti-1304	156	21	growth	growth	NOUN
dti-1304	156	22	of	of	ADP
dti-1304	156	23	syrian	syrian	ADJ
dti-1304	156	24	hamster	hamster	PROPN
dti-1304	156	25	embryo	embryo	NOUN
dti-1304	156	26	fi	fi	NOUN
dti-1304	156	27	broblasts	broblast	NOUN
dti-1304	156	28	under	under	ADP
dti-1304	156	29	growth	growth	NOUN
dti-1304	156	30	factor	factor	NOUN
dti-1304	156	31	stimulation	stimulation	NOUN
dti-1304	156	32	suggests	suggest	VERB
dti-1304	156	33	that	that	SCONJ
dti-1304	156	34	similar	similar	ADJ
dti-1304	156	35	alteration	alteration	NOUN
dti-1304	156	36	in	in	ADP
dti-1304	156	37	signaling	signal	VERB
dti-1304	156	38	proteins	protein	NOUN
dti-1304	156	39	might	might	AUX
dti-1304	156	40	be	be	AUX
dti-1304	156	41	involved	involve	VERB
dti-1304	156	42	in	in	ADP
dti-1304	156	43	the	the	DET
dti-1304	156	44	acquisition	acquisition	NOUN
dti-1304	156	45	of	of	ADP
dti-1304	156	46	the	the	DET
dti-1304	156	47	transformed	transform	VERB
dti-1304	156	48	phenotype	phenotype	NOUN
dti-1304	156	49	of	of	ADP
dti-1304	156	50	ra	ra	PROPN
dti-1304	156	51	-	-	PUNCT
dti-1304	156	52	sfl	sfl	PROPN
dti-1304	156	53	cells	cell	NOUN
dti-1304	156	54	[	[	X
dti-1304	156	55	kameda	kameda	X
dti-1304	156	56	et	et	PROPN
dti-1304	156	57	al	al	PROPN
dti-1304	156	58	.	.	PROPN
dti-1304	156	59	2001	2001	NUM
dti-1304	156	60	]	]	PUNCT
dti-1304	156	61	.	.	PUNCT
dti-1304	157	1	this	this	PRON
dti-1304	157	2	is	be	AUX
dti-1304	157	3	supported	support	VERB
dti-1304	157	4	by	by	ADP
dti-1304	157	5	the	the	DET
dti-1304	157	6	fact	fact	NOUN
dti-1304	157	7	that	that	SCONJ
dti-1304	157	8	pdgf	pdgf	ADJ
dti-1304	157	9	stimulation	stimulation	NOUN
dti-1304	157	10	enhanced	enhance	VERB
dti-1304	157	11	anchorage	anchorage	NOUN
dti-1304	157	12	-	-	PUNCT
dti-1304	157	13	independent	independent	ADJ
dti-1304	157	14	growth	growth	NOUN
dti-1304	157	15	of	of	ADP
dti-1304	157	16	ra	ra	PROPN
dti-1304	157	17	-	-	PUNCT
dti-1304	157	18	sfl	sfl	PROPN
dti-1304	157	19	cells	cell	NOUN
dti-1304	157	20	[	[	X
dti-1304	157	21	kameda	kameda	X
dti-1304	157	22	et	et	PROPN
dti-1304	157	23	al	al	PROPN
dti-1304	157	24	.	.	PROPN
dti-1304	157	25	2006	2006	NUM
dti-1304	157	26	]	]	PUNCT
dti-1304	157	27	.	.	PUNCT
dti-1304	158	1	recent	recent	ADJ
dti-1304	158	2	reports	report	NOUN
dti-1304	158	3	on	on	ADP
dti-1304	158	4	ra	ra	PROPN
dti-1304	158	5	patients	patient	NOUN
dti-1304	158	6	successfully	successfully	ADV
dti-1304	158	7	treated	treat	VERB
dti-1304	158	8	with	with	ADP
dti-1304	158	9	imatinib	imatinib	NOUN
dti-1304	158	10	were	be	AUX
dti-1304	158	11	more	more	ADV
dti-1304	158	12	encouraging	encouraging	ADJ
dti-1304	158	13	than	than	ADP
dti-1304	158	14	above	above	ADV
dti-1304	158	15	in	in	ADP
dti-1304	158	16	vitro	vitro	X
dti-1304	158	17	and	and	CCONJ
dti-1304	158	18	in	in	ADP
dti-1304	158	19	vivo	vivo	NOUN
dti-1304	158	20	results	result	NOUN
dti-1304	158	21	.	.	PUNCT
dti-1304	159	1	miyachi	miyachi	PROPN
dti-1304	159	2	et	et	PROPN
dti-1304	159	3	al	al	PROPN
dti-1304	159	4	.	.	PROPN
dti-1304	159	5	reported	report	VERB
dti-1304	159	6	a	a	DET
dti-1304	159	7	case	case	NOUN
dti-1304	159	8	with	with	ADP
dti-1304	159	9	ra	ra	PROPN
dti-1304	159	10	and	and	CCONJ
dti-1304	159	11	chronic	chronic	ADJ
dti-1304	159	12	myeloid	myeloid	NOUN
dti-1304	159	13	leukemia	leukemia	NOUN
dti-1304	159	14	,	,	PUNCT
dti-1304	159	15	both	both	PRON
dti-1304	159	16	of	of	ADP
dti-1304	159	17	which	which	PRON
dti-1304	159	18	were	be	AUX
dti-1304	159	19	successfully	successfully	ADV
dti-1304	159	20	treated	treat	VERB
dti-1304	159	21	using	use	VERB
dti-1304	159	22	imatinib	imatinib	NOUN
dti-1304	160	1	[	[	X
dti-1304	160	2	miyachi	miyachi	NOUN
dti-1304	160	3	et	et	PROPN
dti-1304	160	4	al	al	PROPN
dti-1304	160	5	.	.	PROPN
dti-1304	160	6	2003	2003	NUM
dti-1304	160	7	]	]	PUNCT
dti-1304	160	8	.	.	PUNCT
dti-1304	161	1	moreover	moreover	ADV
dti-1304	161	2	,	,	PUNCT
dti-1304	161	3	eklund	eklund	PROPN
dti-1304	161	4	et	et	PROPN
dti-1304	161	5	al	al	PROPN
dti-1304	161	6	.	.	PROPN
dti-1304	161	7	described	describe	VERB
dti-1304	161	8	three	three	NUM
dti-1304	161	9	patients	patient	NOUN
dti-1304	161	10	with	with	ADP
dti-1304	161	11	severe	severe	ADJ
dti-1304	161	12	ra	ra	PROPN
dti-1304	161	13	who	who	PRON
dti-1304	161	14	were	be	AUX
dti-1304	161	15	treated	treat	VERB
dti-1304	161	16	for	for	ADP
dti-1304	161	17	12	12	NUM
dti-1304	161	18	weeks	week	NOUN
dti-1304	161	19	with	with	ADP
dti-1304	161	20	escalating	escalate	VERB
dti-1304	161	21	daily	daily	ADJ
dti-1304	161	22	doses	dose	NOUN
dti-1304	161	23	(	(	PUNCT
dti-1304	161	24	from	from	ADP
dti-1304	161	25	100	100	NUM
dti-1304	161	26	to	to	PART
dti-1304	161	27	400	400	NUM
dti-1304	161	28	mg	mg	NOUN
dti-1304	161	29	)	)	PUNCT
dti-1304	161	30	of	of	ADP
dti-1304	161	31	imatinib	imatinib	NOUN
dti-1304	161	32	[	[	X
dti-1304	161	33	eklund	eklund	NOUN
dti-1304	161	34	and	and	CCONJ
dti-1304	161	35	joensuu	joensuu	NOUN
dti-1304	161	36	,	,	PUNCT
dti-1304	161	37	2003	2003	NUM
dti-1304	161	38	]	]	PUNCT
dti-1304	161	39	.	.	PUNCT
dti-1304	162	1	all	all	DET
dti-1304	162	2	three	three	NUM
dti-1304	162	3	patients	patient	NOUN
dti-1304	162	4	had	have	AUX
dti-1304	162	5	failed	fail	VERB
dti-1304	162	6	to	to	PART
dti-1304	162	7	respond	respond	VERB
dti-1304	162	8	to	to	ADP
dti-1304	162	9	prior	prior	ADJ
dti-1304	162	10	anti	anti	ADJ
dti-1304	162	11	-	-	ADJ
dti-1304	162	12	rheumatic	rheumatic	ADJ
dti-1304	162	13	medications	medication	NOUN
dti-1304	162	14	,	,	PUNCT
dti-1304	162	15	including	include	VERB
dti-1304	162	16	methotrexate	methotrexate	NOUN
dti-1304	162	17	and	and	CCONJ
dti-1304	162	18	infl	infl	PROPN
dti-1304	162	19	iximab	iximab	PROPN
dti-1304	162	20	.	.	PUNCT
dti-1304	163	1	all	all	PRON
dti-1304	163	2	reported	report	VERB
dti-1304	163	3	less	less	ADJ
dti-1304	163	4	pain	pain	NOUN
dti-1304	163	5	and	and	CCONJ
dti-1304	163	6	disease	disease	NOUN
dti-1304	163	7	activity	activity	NOUN
dti-1304	163	8	,	,	PUNCT
dti-1304	163	9	and	and	CCONJ
dti-1304	163	10	their	their	PRON
dti-1304	163	11	health	health	NOUN
dti-1304	163	12	assessment	assessment	NOUN
dti-1304	163	13	questionnaire	questionnaire	NOUN
dti-1304	163	14	scores	score	NOUN
dti-1304	163	15	improved	improve	VERB
dti-1304	163	16	subsequent	subsequent	ADJ
dti-1304	163	17	to	to	ADP
dti-1304	163	18	the	the	DET
dti-1304	163	19	imatinib	imatinib	PROPN
dti-1304	163	20	treatment	treatment	NOUN
dti-1304	163	21	.	.	PUNCT
dti-1304	164	1	therefore	therefore	ADV
dti-1304	164	2	,	,	PUNCT
dti-1304	164	3	the	the	DET
dti-1304	164	4	addition	addition	NOUN
dti-1304	164	5	of	of	ADP
dti-1304	164	6	,	,	PUNCT
dti-1304	164	7	or	or	CCONJ
dti-1304	164	8	the	the	DET
dti-1304	164	9	switching	switching	NOUN
dti-1304	164	10	to	to	ADP
dti-1304	164	11	,	,	PUNCT
dti-1304	164	12	imatinib	imatinib	NOUN
dti-1304	164	13	may	may	AUX
dti-1304	164	14	be	be	AUX
dti-1304	164	15	benefi	benefi	PROPN
dti-1304	164	16	cial	cial	NOUN
dti-1304	164	17	to	to	ADP
dti-1304	164	18	patients	patient	NOUN
dti-1304	164	19	with	with	ADP
dti-1304	164	20	ra	ra	PROPN
dti-1304	164	21	who	who	PRON
dti-1304	164	22	failed	fail	VERB
dti-1304	164	23	in	in	ADP
dti-1304	164	24	conventional	conventional	ADJ
dti-1304	164	25	therapies	therapy	NOUN
dti-1304	164	26	.	.	PUNCT
dti-1304	165	1	perspective	perspective	NOUN
dti-1304	165	2	and	and	CCONJ
dti-1304	165	3	conclusion	conclusion	NOUN
dti-1304	165	4	besides	besides	SCONJ
dti-1304	165	5	those	those	PRON
dti-1304	165	6	described	describe	VERB
dti-1304	165	7	above	above	ADV
dti-1304	165	8	,	,	PUNCT
dti-1304	165	9	pdgf	pdgf	NOUN
dti-1304	165	10	is	be	AUX
dti-1304	165	11	a	a	DET
dti-1304	165	12	fascinating	fascinating	ADJ
dti-1304	165	13	molecular	molecular	ADJ
dti-1304	165	14	target	target	NOUN
dti-1304	165	15	in	in	ADP
dti-1304	165	16	various	various	ADJ
dti-1304	165	17	other	other	ADJ
dti-1304	165	18	systemic	systemic	ADJ
dti-1304	165	19	rheumatic	rheumatic	ADJ
dti-1304	165	20	diseases	disease	NOUN
dti-1304	165	21	such	such	ADJ
dti-1304	165	22	as	as	ADP
dti-1304	165	23	spondyloarthropathy	spondyloarthropathy	ADJ
dti-1304	165	24	and	and	CCONJ
dti-1304	165	25	systemic	systemic	ADJ
dti-1304	165	26	vasculitis	vasculitis	PROPN
dti-1304	165	27	.	.	PUNCT
dti-1304	166	1	the	the	DET
dti-1304	166	2	strategies	strategy	NOUN
dti-1304	166	3	of	of	ADP
dti-1304	166	4	pdgf	pdgf	NOUN
dti-1304	166	5	signaling	signal	VERB
dti-1304	166	6	inhibition	inhibition	NOUN
dti-1304	166	7	include	include	VERB
dti-1304	166	8	antibodies	antibody	NOUN
dti-1304	166	9	against	against	ADP
dti-1304	166	10	pdgf	pdgf	NOUN
dti-1304	166	11	or	or	CCONJ
dti-1304	166	12	pdgf	pdgf	ADJ
dti-1304	166	13	-	-	PUNCT
dti-1304	166	14	r	r	NOUN
dti-1304	166	15	,	,	PUNCT
dti-1304	166	16	soluble	soluble	ADJ
dti-1304	166	17	recombinant	recombinant	ADJ
dti-1304	166	18	fusion	fusion	NOUN
dti-1304	166	19	proteins	protein	NOUN
dti-1304	166	20	of	of	ADP
dti-1304	166	21	pdgf	pdgf	NOUN
dti-1304	166	22	-	-	PUNCT
dti-1304	166	23	r	r	NOUN
dti-1304	166	24	and	and	CCONJ
dti-1304	166	25	igg	igg	PROPN
dti-1304	166	26	,	,	PUNCT
dti-1304	166	27	oligonucleotide	oligonucleotide	VERB
dti-1304	166	28	245	245	NUM
dti-1304	166	29	pdgf	pdgf	NOUN
dti-1304	166	30	as	as	ADP
dti-1304	166	31	a	a	DET
dti-1304	166	32	target	target	NOUN
dti-1304	166	33	for	for	ADP
dti-1304	166	34	systemic	systemic	ADJ
dti-1304	166	35	autoimmune	autoimmune	ADJ
dti-1304	166	36	diseases	disease	NOUN
dti-1304	166	37	drug	drug	NOUN
dti-1304	166	38	target	target	NOUN
dti-1304	166	39	insights	insight	NOUN
dti-1304	166	40	2007:2	2007:2	NUM
dti-1304	166	41	figure	figure	NOUN
dti-1304	166	42	2	2	NUM
dti-1304	166	43	.	.	NUM
dti-1304	166	44	predicted	predict	VERB
dti-1304	166	45	molecular	molecular	ADJ
dti-1304	166	46	mechanisms	mechanism	NOUN
dti-1304	166	47	and	and	CCONJ
dti-1304	166	48	possible	possible	ADJ
dti-1304	166	49	therapeutic	therapeutic	ADJ
dti-1304	166	50	targets	target	NOUN
dti-1304	166	51	of	of	ADP
dti-1304	166	52	rheumatic	rheumatic	ADJ
dti-1304	166	53	infl	infl	PROPN
dti-1304	166	54	ammation	ammation	NOUN
dti-1304	166	55	and	and	CCONJ
dti-1304	166	56	fi	fi	NOUN
dti-1304	166	57	brosis	brosis	NOUN
dti-1304	166	58	.	.	PUNCT
dti-1304	167	1	various	various	ADJ
dti-1304	167	2	cell	cell	NOUN
dti-1304	167	3	types	type	NOUN
dti-1304	167	4	shown	show	VERB
dti-1304	167	5	here	here	ADV
dti-1304	167	6	are	be	AUX
dti-1304	167	7	likely	likely	ADJ
dti-1304	167	8	to	to	PART
dti-1304	167	9	be	be	AUX
dti-1304	167	10	involved	involve	VERB
dti-1304	167	11	in	in	ADP
dti-1304	167	12	the	the	DET
dti-1304	167	13	development	development	NOUN
dti-1304	167	14	and	and	CCONJ
dti-1304	167	15	progression	progression	NOUN
dti-1304	167	16	of	of	ADP
dti-1304	167	17	rheumatic	rheumatic	ADJ
dti-1304	167	18	infl	infl	PROPN
dti-1304	167	19	ammation	ammation	PROPN
dti-1304	167	20	.	.	PUNCT
dti-1304	168	1	autoimmune	autoimmune	ADJ
dti-1304	168	2	responses	response	NOUN
dti-1304	168	3	and	and	CCONJ
dti-1304	168	4	the	the	DET
dti-1304	168	5	subsequent	subsequent	ADJ
dti-1304	168	6	infi	infi	PROPN
dti-1304	168	7	ltration	ltration	NOUN
dti-1304	168	8	of	of	ADP
dti-1304	168	9	neutrophils	neutrophil	NOUN
dti-1304	168	10	and	and	CCONJ
dti-1304	168	11	lymphocytes	lymphocyte	NOUN
dti-1304	168	12	are	be	AUX
dti-1304	168	13	known	know	VERB
dti-1304	168	14	to	to	PART
dti-1304	168	15	occur	occur	VERB
dti-1304	168	16	.	.	PUNCT
dti-1304	169	1	resident	resident	ADJ
dti-1304	169	2	macrophage	macrophage	ADJ
dti-1304	169	3	activation	activation	NOUN
dti-1304	169	4	,	,	PUNCT
dti-1304	169	5	increased	increase	VERB
dti-1304	169	6	apoptosis	apoptosis	NOUN
dti-1304	169	7	of	of	ADP
dti-1304	169	8	epithelial	epithelial	ADJ
dti-1304	169	9	cells	cell	NOUN
dti-1304	169	10	and	and	CCONJ
dti-1304	169	11	endothelial	endothelial	ADJ
dti-1304	169	12	dysfuction	dysfuction	NOUN
dti-1304	169	13	may	may	AUX
dti-1304	169	14	result	result	VERB
dti-1304	169	15	in	in	ADP
dti-1304	169	16	the	the	DET
dti-1304	169	17	formation	formation	NOUN
dti-1304	169	18	of	of	ADP
dti-1304	169	19	fi	fi	NOUN
dti-1304	169	20	brin	brin	NOUN
dti-1304	169	21	clots	clot	NOUN
dti-1304	169	22	and	and	CCONJ
dti-1304	169	23	a	a	DET
dti-1304	169	24	provisional	provisional	ADJ
dti-1304	169	25	matrix	matrix	NOUN
dti-1304	169	26	,	,	PUNCT
dti-1304	169	27	initiating	initiate	VERB
dti-1304	169	28	the	the	DET
dti-1304	169	29	proliferation	proliferation	NOUN
dti-1304	169	30	of	of	ADP
dti-1304	169	31	fi	fi	NOUN
dti-1304	169	32	broblasts	broblast	NOUN
dti-1304	169	33	.	.	PUNCT
dti-1304	170	1	any	any	PRON
dti-1304	170	2	of	of	ADP
dti-1304	170	3	those	those	DET
dti-1304	170	4	cells	cell	NOUN
dti-1304	170	5	could	could	AUX
dti-1304	170	6	serve	serve	VERB
dti-1304	170	7	as	as	ADP
dti-1304	170	8	therapeutic	therapeutic	ADJ
dti-1304	170	9	targets	target	NOUN
dti-1304	170	10	in	in	ADP
dti-1304	170	11	the	the	DET
dti-1304	170	12	treatment	treatment	NOUN
dti-1304	170	13	of	of	ADP
dti-1304	170	14	systemic	systemic	ADJ
dti-1304	170	15	rheumatic	rheumatic	ADJ
dti-1304	170	16	diseases	disease	NOUN
dti-1304	170	17	,	,	PUNCT
dti-1304	170	18	and	and	CCONJ
dti-1304	170	19	a	a	DET
dti-1304	170	20	simultaneous	simultaneous	ADJ
dti-1304	170	21	control	control	NOUN
dti-1304	170	22	of	of	ADP
dti-1304	170	23	them	they	PRON
dti-1304	170	24	seems	seem	VERB
dti-1304	170	25	to	to	PART
dti-1304	170	26	be	be	AUX
dti-1304	170	27	essential	essential	ADJ
dti-1304	170	28	in	in	ADP
dti-1304	170	29	overwhelming	overwhelm	VERB
dti-1304	170	30	the	the	DET
dti-1304	170	31	persistent	persistent	ADJ
dti-1304	170	32	infl	infl	PROPN
dti-1304	170	33	ammation	ammation	PROPN
dti-1304	170	34	.	.	PUNCT
dti-1304	171	1	table	table	NOUN
dti-1304	171	2	1	1	NUM
dti-1304	171	3	.	.	PUNCT
dti-1304	172	1	summary	summary	NOUN
dti-1304	172	2	of	of	ADP
dti-1304	172	3	preclinical	preclinical	ADJ
dti-1304	172	4	fi	fi	NOUN
dti-1304	172	5	ndings	nding	NOUN
dti-1304	172	6	positively	positively	ADV
dti-1304	172	7	supporting	support	VERB
dti-1304	172	8	the	the	DET
dti-1304	172	9	application	application	NOUN
dti-1304	172	10	of	of	ADP
dti-1304	172	11	imatinib	imatinib	NOUN
dti-1304	172	12	for	for	ADP
dti-1304	172	13	systemic	systemic	ADJ
dti-1304	172	14	rheumatic	rheumatic	ADJ
dti-1304	172	15	diseases	disease	NOUN
dti-1304	172	16	.	.	PUNCT
dti-1304	173	1	ssc	ssc	NOUN
dti-1304	173	2	:	:	PUNCT
dti-1304	173	3	inhibition	inhibition	NOUN
dti-1304	173	4	of	of	ADP
dti-1304	173	5	the	the	DET
dti-1304	173	6	differentiation	differentiation	NOUN
dti-1304	173	7	of	of	ADP
dti-1304	173	8	fi	fi	NOUN
dti-1304	173	9	broblast	broblast	ADJ
dti-1304	173	10	into	into	ADP
dti-1304	173	11	myofi	myofi	PROPN
dti-1304	173	12	broblast	broblast	ADJ
dti-1304	173	13	,	,	PUNCT
dti-1304	173	14	proliferation	proliferation	NOUN
dti-1304	173	15	,	,	PUNCT
dti-1304	173	16	and	and	CCONJ
dti-1304	173	17	ecm	ecm	NOUN
dti-1304	173	18	production	production	NOUN
dti-1304	173	19	[	[	X
dti-1304	173	20	distler	distler	NOUN
dti-1304	173	21	et	et	PROPN
dti-1304	173	22	al	al	PROPN
dti-1304	173	23	.	.	PROPN
dti-1304	173	24	2007	2007	NUM
dti-1304	173	25	,	,	PUNCT
dti-1304	173	26	in	in	ADP
dti-1304	173	27	vitro	vitro	X
dti-1304	173	28	and	and	CCONJ
dti-1304	173	29	in	in	ADP
dti-1304	173	30	vivo	vivo	NOUN
dti-1304	173	31	]	]	PUNCT
dti-1304	173	32	pah	pah	PROPN
dti-1304	173	33	:	:	PUNCT
dti-1304	173	34	inhibition	inhibition	NOUN
dti-1304	173	35	of	of	ADP
dti-1304	173	36	medical	medical	ADJ
dti-1304	173	37	thickening	thickening	NOUN
dti-1304	173	38	of	of	ADP
dti-1304	173	39	pulmonary	pulmonary	ADJ
dti-1304	173	40	arteries	artery	NOUN
dti-1304	173	41	leading	lead	VERB
dti-1304	173	42	to	to	ADP
dti-1304	173	43	the	the	DET
dti-1304	173	44	improvement	improvement	NOUN
dti-1304	173	45	in	in	ADP
dti-1304	173	46	right	right	ADJ
dti-1304	173	47	ventricular	ventricular	ADJ
dti-1304	173	48	pressure	pressure	NOUN
dti-1304	173	49	,	,	PUNCT
dti-1304	173	50	cardiac	cardiac	ADJ
dti-1304	173	51	output	output	NOUN
dti-1304	173	52	,	,	PUNCT
dti-1304	173	53	and	and	CCONJ
dti-1304	173	54	arterial	arterial	ADJ
dti-1304	173	55	pressure	pressure	NOUN
dti-1304	173	56	of	of	ADP
dti-1304	173	57	oxygen	oxygen	NOUN
dti-1304	174	1	[	[	X
dti-1304	174	2	schermyuly	schermyuly	ADV
dti-1304	174	3	et	et	PROPN
dti-1304	174	4	al	al	PROPN
dti-1304	174	5	.	.	PROPN
dti-1304	174	6	2005	2005	NUM
dti-1304	174	7	,	,	PUNCT
dti-1304	174	8	in	in	ADP
dti-1304	174	9	vivo	vivo	NOUN
dti-1304	174	10	]	]	PUNCT
dti-1304	174	11	ild	ild	NOUN
dti-1304	174	12	:	:	PUNCT
dti-1304	174	13	inhibition	inhibition	NOUN
dti-1304	174	14	of	of	ADP
dti-1304	174	15	the	the	DET
dti-1304	174	16	differentiation	differentiation	NOUN
dti-1304	174	17	of	of	ADP
dti-1304	174	18	fi	fi	NOUN
dti-1304	174	19	broblast	broblast	ADJ
dti-1304	174	20	into	into	ADP
dti-1304	174	21	myofi	myofi	PROPN
dti-1304	174	22	broblast	broblast	ADJ
dti-1304	174	23	,	,	PUNCT
dti-1304	174	24	proliferation	proliferation	NOUN
dti-1304	174	25	,	,	PUNCT
dti-1304	174	26	and	and	CCONJ
dti-1304	174	27	ecm	ecm	NOUN
dti-1304	174	28	production	production	NOUN
dti-1304	174	29	,	,	PUNCT
dti-1304	174	30	leading	lead	VERB
dti-1304	174	31	to	to	ADP
dti-1304	174	32	histologic	histologic	PROPN
dti-1304	174	33	effi	effi	PROPN
dti-1304	174	34	cacy	cacy	NOUN
dti-1304	174	35	[	[	X
dti-1304	174	36	daniels	daniels	PROPN
dti-1304	174	37	et	et	PROPN
dti-1304	174	38	al	al	PROPN
dti-1304	174	39	.	.	PROPN
dti-1304	174	40	2004	2004	NUM
dti-1304	174	41	;	;	PUNCT
dti-1304	174	42	aono	aono	PROPN
dti-1304	174	43	et	et	PROPN
dti-1304	174	44	al	al	PROPN
dti-1304	174	45	.	.	PROPN
dti-1304	174	46	2005	2005	NUM
dti-1304	174	47	;	;	PUNCT
dti-1304	174	48	in	in	ADP
dti-1304	174	49	vitro	vitro	X
dti-1304	174	50	and	and	CCONJ
dti-1304	174	51	in	in	ADP
dti-1304	174	52	vivo	vivo	NOUN
dti-1304	174	53	;	;	PUNCT
dti-1304	174	54	abdollahi	abdollahi	PROPN
dti-1304	174	55	et	et	PROPN
dti-1304	174	56	al	al	PROPN
dti-1304	174	57	.	.	PROPN
dti-1304	174	58	2005	2005	NUM
dti-1304	174	59	;	;	PUNCT
dti-1304	174	60	chaudhary	chaudhary	PROPN
dti-1304	174	61	et	et	PROPN
dti-1304	174	62	al	al	PROPN
dti-1304	174	63	.	.	PROPN
dti-1304	174	64	2006	2006	NUM
dti-1304	174	65	,	,	PUNCT
dti-1304	174	66	in	in	ADP
dti-1304	174	67	vivo	vivo	NOUN
dti-1304	174	68	]	]	PUNCT
dti-1304	174	69	lupus	lupus	PROPN
dti-1304	174	70	nephritis	nephritis	NOUN
dti-1304	174	71	:	:	PUNCT
dti-1304	174	72	inhibition	inhibition	NOUN
dti-1304	174	73	of	of	ADP
dti-1304	174	74	mesangial	mesangial	ADJ
dti-1304	174	75	proliferation	proliferation	NOUN
dti-1304	174	76	,	,	PUNCT
dti-1304	174	77	ecm	ecm	NOUN
dti-1304	174	78	production	production	NOUN
dti-1304	174	79	,	,	PUNCT
dti-1304	174	80	and	and	CCONJ
dti-1304	174	81	crescentic	crescentic	ADJ
dti-1304	174	82	formation	formation	NOUN
dti-1304	174	83	leading	lead	VERB
dti-1304	174	84	to	to	PART
dti-1304	174	85	decrease	decrease	VERB
dti-1304	174	86	in	in	ADP
dti-1304	174	87	proteinuria	proteinuria	NOUN
dti-1304	174	88	and	and	CCONJ
dti-1304	174	89	improvement	improvement	NOUN
dti-1304	174	90	in	in	ADP
dti-1304	174	91	renal	renal	ADJ
dti-1304	174	92	failure	failure	NOUN
dti-1304	174	93	[	[	X
dti-1304	174	94	gilbert	gilbert	X
dti-1304	174	95	et	et	PROPN
dti-1304	174	96	al	al	PROPN
dti-1304	174	97	.	.	PROPN
dti-1304	174	98	2001	2001	NUM
dti-1304	174	99	;	;	PUNCT
dti-1304	174	100	sadanaga	sadanaga	PROPN
dti-1304	174	101	et	et	PROPN
dti-1304	174	102	al	al	PROPN
dti-1304	174	103	.	.	PROPN
dti-1304	174	104	2005	2005	NUM
dti-1304	174	105	;	;	PUNCT
dti-1304	174	106	zoja	zoja	PROPN
dti-1304	174	107	et	et	PROPN
dti-1304	174	108	al	al	PROPN
dti-1304	174	109	.	.	PROPN
dti-1304	174	110	2006	2006	NUM
dti-1304	174	111	,	,	PUNCT
dti-1304	174	112	in	in	ADP
dti-1304	174	113	vivo	vivo	NOUN
dti-1304	174	114	]	]	X
dti-1304	174	115	ra	ra	NOUN
dti-1304	174	116	:	:	PUNCT
dti-1304	174	117	inhibition	inhibition	NOUN
dti-1304	174	118	of	of	ADP
dti-1304	174	119	transformation	transformation	NOUN
dti-1304	174	120	/	/	SYM
dti-1304	174	121	proliferation	proliferation	NOUN
dti-1304	174	122	of	of	ADP
dti-1304	174	123	synovial	synovial	ADJ
dti-1304	174	124	fi	fi	NOUN
dti-1304	174	125	broblasts	broblast	NOUN
dti-1304	174	126	[	[	X
dti-1304	174	127	kameda	kameda	X
dti-1304	174	128	et	et	PROPN
dti-1304	174	129	al	al	PROPN
dti-1304	174	130	.	.	PROPN
dti-1304	174	131	2006	2006	NUM
dti-1304	174	132	;	;	PUNCT
dti-1304	174	133	sandler	sandler	PROPN
dti-1304	174	134	et	et	PROPN
dti-1304	174	135	al	al	PROPN
dti-1304	174	136	.	.	PROPN
dti-1304	174	137	2006	2006	NUM
dti-1304	174	138	,	,	PUNCT
dti-1304	174	139	in	in	ADP
dti-1304	174	140	vitro	vitro	VERB
dti-1304	174	141	]	]	PUNCT
dti-1304	174	142	,	,	PUNCT
dti-1304	174	143	delay	delay	NOUN
dti-1304	174	144	in	in	ADP
dti-1304	174	145	joint	joint	ADJ
dti-1304	174	146	destruction	destruction	NOUN
dti-1304	175	1	[	[	X
dti-1304	175	2	paniagua	paniagua	X
dti-1304	175	3	et	et	VERB
dti-1304	175	4	al	al	PROPN
dti-1304	175	5	.	.	PROPN
dti-1304	175	6	2006	2006	NUM
dti-1304	175	7	;	;	PUNCT
dti-1304	175	8	ando	ando	PROPN
dti-1304	175	9	et	et	PROPN
dti-1304	175	10	al	al	PROPN
dti-1304	175	11	.	.	PROPN
dti-1304	175	12	2006	2006	NUM
dti-1304	175	13	,	,	PUNCT
dti-1304	175	14	in	in	ADP
dti-1304	175	15	vivo	vivo	NOUN
dti-1304	175	16	]	]	PUNCT
dti-1304	175	17	endothelial	endothelial	ADJ
dti-1304	175	18	cell	cell	NOUN
dti-1304	175	19	#	#	NOUN
dti-1304	175	20	anti	anti	ADJ
dti-1304	175	21	-	-	ADJ
dti-1304	175	22	thrombosis	thrombosis	ADJ
dti-1304	175	23	epithelial	epithelial	ADJ
dti-1304	175	24	cell	cell	NOUN
dti-1304	175	25	#	#	NOUN
dti-1304	176	1	antigen	antigen	NOUN
dti-1304	176	2	presentation	presentation	NOUN
dti-1304	176	3	#	#	NOUN
dti-1304	176	4	apoptosis	apoptosis	NOUN
dti-1304	176	5	#	#	NOUN
dti-1304	176	6	cytokine	cytokine	NOUN
dti-1304	176	7	production	production	NOUN
dti-1304	176	8	alveolar	alveolar	ADJ
dti-1304	176	9	macrophage	macrophage	NOUN
dti-1304	176	10	#	#	NOUN
dti-1304	176	11	tnf	tnf	PROPN
dti-1304	176	12	α	α	PROPN
dti-1304	176	13	production	production	NOUN
dti-1304	176	14	#	#	NOUN
dti-1304	176	15	chemokine	chemokine	ADJ
dti-1304	176	16	production	production	NOUN
dti-1304	176	17	neutrophil	neutrophil	ADJ
dti-1304	176	18	#	#	NOUN
dti-1304	176	19	superoxide	superoxide	NOUN
dti-1304	176	20	production	production	NOUN
dti-1304	176	21	#	#	NOUN
dti-1304	176	22	proteinase	proteinase	NOUN
dti-1304	176	23	secretion	secretion	NOUN
dti-1304	176	24	lymphocyte	lymphocyte	NOUN
dti-1304	176	25	#	#	NOUN
dti-1304	176	26	lymphokine	lymphokine	ADJ
dti-1304	176	27	production	production	NOUN
dti-1304	176	28	#	#	NOUN
dti-1304	176	29	autoantibody	autoantibody	NOUN
dti-1304	176	30	production	production	NOUN
dti-1304	176	31	#	#	NOUN
dti-1304	176	32	complement	complement	NOUN
dti-1304	176	33	activation	activation	NOUN
dti-1304	176	34	fibroblast	fibroblast	ADJ
dti-1304	176	35	#	#	NOUN
dti-1304	176	36	myofibroblast	myofibroblast	NOUN
dti-1304	176	37	differentiation	differentiation	NOUN
dti-1304	176	38	#	#	NOUN
dti-1304	176	39	migration	migration	NOUN
dti-1304	176	40	and	and	CCONJ
dti-1304	176	41	proliferation	proliferation	NOUN
dti-1304	176	42	#	#	NOUN
dti-1304	176	43	provisional	provisional	ADJ
dti-1304	176	44	ecm	ecm	NOUN
dti-1304	176	45	secretion	secretion	NOUN
dti-1304	176	46	#	#	PROPN
dti-1304	176	47	angiotensin	angiotensin	NOUN
dti-1304	176	48	ii	ii	PROPN
dti-1304	176	49	secretion	secretion	NOUN
dti-1304	176	50	246	246	NUM
dti-1304	176	51	kameda	kameda	NOUN
dti-1304	176	52	et	et	PROPN
dti-1304	176	53	al	al	PROPN
dti-1304	176	54	drug	drug	PROPN
dti-1304	176	55	target	target	NOUN
dti-1304	176	56	insights	insight	NOUN
dti-1304	176	57	2007:2	2007:2	NUM
dti-1304	176	58	aptamer	aptamer	NOUN
dti-1304	176	59	interfering	interfere	VERB
dti-1304	176	60	pdgf	pdgf	ADJ
dti-1304	176	61	-	-	PUNCT
dti-1304	176	62	r	r	NOUN
dti-1304	176	63	signaling	signaling	NOUN
dti-1304	176	64	,	,	PUNCT
dti-1304	176	65	and	and	CCONJ
dti-1304	176	66	inhibitors	inhibitor	NOUN
dti-1304	176	67	of	of	ADP
dti-1304	176	68	pdgf	pdgf	ADJ
dti-1304	176	69	-	-	PUNCT
dti-1304	176	70	r	r	NOUN
dti-1304	176	71	tyrosine	tyrosine	NOUN
dti-1304	176	72	kinase	kinase	NOUN
dti-1304	176	73	or	or	CCONJ
dti-1304	176	74	downstream	downstream	ADJ
dti-1304	176	75	signaling	signal	VERB
dti-1304	176	76	molecules	molecule	NOUN
dti-1304	176	77	.	.	PUNCT
dti-1304	177	1	among	among	ADP
dti-1304	177	2	many	many	ADJ
dti-1304	177	3	candidates	candidate	NOUN
dti-1304	177	4	,	,	PUNCT
dti-1304	177	5	imatinib	imatinib	NOUN
dti-1304	177	6	possesses	possess	VERB
dti-1304	177	7	some	some	DET
dti-1304	177	8	advantages	advantage	NOUN
dti-1304	177	9	in	in	ADP
dti-1304	177	10	:	:	PUNCT
dti-1304	177	11	1	1	X
dti-1304	177	12	)	)	PUNCT
dti-1304	177	13	clinical	clinical	ADJ
dti-1304	177	14	use	use	NOUN
dti-1304	177	15	with	with	ADP
dti-1304	177	16	well	well	ADV
dti-1304	177	17	acceptable	acceptable	ADJ
dti-1304	177	18	tolerability	tolerability	NOUN
dti-1304	177	19	;	;	PUNCT
dti-1304	177	20	2	2	X
dti-1304	177	21	)	)	PUNCT
dti-1304	177	22	additional	additional	ADJ
dti-1304	177	23	inhibition	inhibition	NOUN
dti-1304	177	24	of	of	ADP
dti-1304	177	25	abl	abl	NOUN
dti-1304	177	26	and	and	CCONJ
dti-1304	177	27	c	c	NOUN
dti-1304	177	28	-	-	PUNCT
dti-1304	177	29	kit	kit	NOUN
dti-1304	177	30	,	,	PUNCT
dti-1304	177	31	which	which	PRON
dti-1304	177	32	leads	lead	VERB
dti-1304	177	33	to	to	ADP
dti-1304	177	34	the	the	DET
dti-1304	177	35	suppression	suppression	NOUN
dti-1304	177	36	of	of	ADP
dti-1304	177	37	tgf	tgf	PROPN
dti-1304	177	38	-	-	PUNCT
dti-1304	177	39	β	β	PROPN
dti-1304	177	40	and	and	CCONJ
dti-1304	177	41	mast	mast	NOUN
dti-1304	177	42	cell	cell	NOUN
dti-1304	177	43	activity	activity	NOUN
dti-1304	177	44	,	,	PUNCT
dti-1304	177	45	respectively	respectively	ADV
dti-1304	177	46	.	.	PUNCT
dti-1304	178	1	thus	thus	ADV
dti-1304	178	2	,	,	PUNCT
dti-1304	178	3	imatinib	imatinib	NOUN
dti-1304	178	4	is	be	AUX
dti-1304	178	5	likely	likely	ADJ
dti-1304	178	6	to	to	PART
dti-1304	178	7	play	play	VERB
dti-1304	178	8	a	a	DET
dti-1304	178	9	multipotent	multipotent	ADJ
dti-1304	178	10	role	role	NOUN
dti-1304	178	11	in	in	ADP
dti-1304	178	12	the	the	DET
dti-1304	178	13	treatment	treatment	NOUN
dti-1304	178	14	of	of	ADP
dti-1304	178	15	various	various	ADJ
dti-1304	178	16	systemic	systemic	ADJ
dti-1304	178	17	rheumatic	rheumatic	ADJ
dti-1304	178	18	diseases	disease	NOUN
dti-1304	178	19	(	(	PUNCT
dti-1304	178	20	table	table	NOUN
dti-1304	178	21	1	1	NUM
dti-1304	178	22	)	)	PUNCT
dti-1304	178	23	.	.	PUNCT
dti-1304	179	1	and	and	CCONJ
dti-1304	179	2	indeed	indeed	ADV
dti-1304	179	3	,	,	PUNCT
dti-1304	179	4	several	several	ADJ
dti-1304	179	5	clinical	clinical	ADJ
dti-1304	179	6	trials	trial	NOUN
dti-1304	179	7	examining	examine	VERB
dti-1304	179	8	the	the	DET
dti-1304	179	9	effi	effi	PROPN
dti-1304	179	10	cacy	cacy	NOUN
dti-1304	179	11	of	of	ADP
dti-1304	179	12	imatinib	imatinib	NOUN
dti-1304	179	13	for	for	ADP
dti-1304	179	14	skin	skin	NOUN
dti-1304	179	15	sclerosis	sclerosis	NOUN
dti-1304	179	16	,	,	PUNCT
dti-1304	179	17	ild	ild	PROPN
dti-1304	179	18	and	and	CCONJ
dti-1304	179	19	pah	pah	PROPN
dti-1304	179	20	are	be	AUX
dti-1304	179	21	ongoing	ongoing	ADJ
dti-1304	179	22	.	.	PUNCT
dti-1304	180	1	to	to	ADP
dti-1304	180	2	date	date	NOUN
dti-1304	180	3	,	,	PUNCT
dti-1304	180	4	the	the	DET
dti-1304	180	5	principal	principal	NOUN
dti-1304	180	6	of	of	ADP
dti-1304	180	7	the	the	DET
dti-1304	180	8	treatment	treatment	NOUN
dti-1304	180	9	for	for	ADP
dti-1304	180	10	systemic	systemic	ADJ
dti-1304	180	11	rheumatic	rheumatic	ADJ
dti-1304	180	12	diseases	disease	NOUN
dti-1304	180	13	has	have	AUX
dti-1304	180	14	been	be	AUX
dti-1304	180	15	chiefl	chiefl	VERB
dti-1304	180	16	y	y	NOUN
dti-1304	180	17	targeting	target	VERB
dti-1304	180	18	leukocytes	leukocyte	NOUN
dti-1304	180	19	.	.	PUNCT
dti-1304	181	1	thus	thus	ADV
dti-1304	181	2	,	,	PUNCT
dti-1304	181	3	future	future	ADJ
dti-1304	181	4	therapeutic	therapeutic	ADJ
dti-1304	181	5	strategies	strategy	NOUN
dti-1304	181	6	should	should	AUX
dti-1304	181	7	focus	focus	VERB
dti-1304	181	8	on	on	ADP
dti-1304	181	9	other	other	ADJ
dti-1304	181	10	cell	cell	NOUN
dti-1304	181	11	types	type	NOUN
dti-1304	181	12	,	,	PUNCT
dti-1304	181	13	including	include	VERB
dti-1304	181	14	fi	fi	NOUN
dti-1304	181	15	broblasts	broblast	NOUN
dti-1304	181	16	,	,	PUNCT
dti-1304	181	17	epithelial	epithelial	ADJ
dti-1304	181	18	cells	cell	NOUN
dti-1304	181	19	and	and	CCONJ
dti-1304	181	20	endothelial	endothelial	NOUN
dti-1304	181	21	cells	cell	NOUN
dti-1304	181	22	(	(	PUNCT
dti-1304	181	23	fig	fig	NOUN
dti-1304	181	24	.	.	PUNCT
dti-1304	182	1	2	2	NUM
dti-1304	182	2	)	)	PUNCT
dti-1304	182	3	.	.	PUNCT
dti-1304	183	1	combined	combine	VERB
dti-1304	183	2	therapy	therapy	NOUN
dti-1304	183	3	of	of	ADP
dti-1304	183	4	antiinfl	antiinfl	PROPN
dti-1304	183	5	ammatory	ammatory	NOUN
dti-1304	183	6	and	and	CCONJ
dti-1304	183	7	anti	anti	ADJ
dti-1304	183	8	-	-	ADJ
dti-1304	183	9	fi	fi	ADJ
dti-1304	183	10	brotic	brotic	ADJ
dti-1304	183	11	agents	agent	NOUN
dti-1304	183	12	may	may	AUX
dti-1304	183	13	shed	shed	VERB
dti-1304	183	14	light	light	NOUN
dti-1304	183	15	on	on	ADP
dti-1304	183	16	the	the	DET
dti-1304	183	17	treatment	treatment	NOUN
dti-1304	183	18	of	of	ADP
dti-1304	183	19	refractory	refractory	NOUN
dti-1304	183	20	diseases	disease	NOUN
dti-1304	183	21	described	describe	VERB
dti-1304	183	22	in	in	ADP
dti-1304	183	23	this	this	DET
dti-1304	183	24	review	review	NOUN
dti-1304	183	25	and	and	CCONJ
dti-1304	183	26	further	far	ADV
dti-1304	183	27	improve	improve	VERB
dti-1304	183	28	the	the	DET
dti-1304	183	29	long	long	ADJ
dti-1304	183	30	-	-	PUNCT
dti-1304	183	31	term	term	NOUN
dti-1304	183	32	survival	survival	NOUN
dti-1304	183	33	of	of	ADP
dti-1304	183	34	patients	patient	NOUN
dti-1304	183	35	with	with	ADP
dti-1304	183	36	systemic	systemic	ADJ
dti-1304	183	37	rheumatic	rheumatic	ADJ
dti-1304	183	38	diseases	disease	NOUN
dti-1304	183	39	.	.	PUNCT
dti-1304	184	1	references	reference	NOUN
dti-1304	184	2	abdollahi	abdollahi	PROPN
dti-1304	184	3	,	,	PUNCT
dti-1304	184	4	a.	a.	PROPN
dti-1304	184	5	,	,	PUNCT
dti-1304	184	6	li	li	PROPN
dti-1304	184	7	,	,	PUNCT
dti-1304	184	8	m.	m.	NOUN
dti-1304	184	9	,	,	PUNCT
dti-1304	184	10	ping	ping	NOUN
dti-1304	184	11	,	,	PUNCT
dti-1304	184	12	g.	g.	PROPN
dti-1304	184	13	et	et	PROPN
dti-1304	184	14	al	al	PROPN
dti-1304	184	15	.	.	PROPN
dti-1304	184	16	2005	2005	NUM
dti-1304	184	17	.	.	PUNCT
dti-1304	185	1	inhibition	inhibition	NOUN
dti-1304	185	2	of	of	ADP
dti-1304	185	3	platelet	platelet	NOUN
dti-1304	185	4	-	-	PUNCT
dti-1304	185	5	derived	derive	VERB
dti-1304	185	6	growth	growth	NOUN
dti-1304	185	7	factor	factor	NOUN
dti-1304	185	8	signaling	signal	VERB
dti-1304	185	9	attenuate	attenuate	VERB
dti-1304	185	10	pulmonary	pulmonary	ADJ
dti-1304	185	11	fi	fi	NOUN
dti-1304	185	12	brosis	brosis	NOUN
dti-1304	185	13	.	.	PUNCT
dti-1304	186	1	j.	j.	PROPN
dti-1304	186	2	exp	exp	PROPN
dti-1304	186	3	.	.	PROPN
dti-1304	186	4	med	med	PROPN
dti-1304	186	5	.	.	PROPN
dti-1304	186	6	,	,	PUNCT
dti-1304	186	7	201:925–35	201:925–35	NUM
dti-1304	186	8	.	.	PUNCT
dti-1304	187	1	american	american	PROPN
dti-1304	187	2	thoracic	thoracic	PROPN
dti-1304	187	3	society	society	NOUN
dti-1304	187	4	.	.	PUNCT
dti-1304	188	1	2000	2000	NUM
dti-1304	188	2	.	.	PUNCT
dti-1304	189	1	idiopathic	idiopathic	ADJ
dti-1304	189	2	pulmonary	pulmonary	ADJ
dti-1304	189	3	fi	fi	NOUN
dti-1304	189	4	brosis	brosis	NOUN
dti-1304	189	5	:	:	PUNCT
dti-1304	189	6	diagnosis	diagnosis	NOUN
dti-1304	189	7	and	and	CCONJ
dti-1304	189	8	treatment	treatment	NOUN
dti-1304	189	9	.	.	PUNCT
dti-1304	190	1	international	international	ADJ
dti-1304	190	2	consensus	consensus	NOUN
dti-1304	190	3	statement	statement	NOUN
dti-1304	190	4	.	.	PUNCT
dti-1304	191	1	am	be	AUX
dti-1304	191	2	.	.	PUNCT
dti-1304	192	1	j.	j.	PROPN
dti-1304	192	2	respir	respir	PROPN
dti-1304	192	3	.	.	PUNCT
dti-1304	193	1	crit	crit	PROPN
dti-1304	193	2	.	.	PUNCT
dti-1304	194	1	care	care	PROPN
dti-1304	194	2	med	med	PROPN
dti-1304	194	3	.	.	PUNCT
dti-1304	194	4	,	,	PUNCT
dti-1304	195	1	161:646–64	161:646–64	NUM
dti-1304	195	2	.	.	PUNCT
dti-1304	196	1	american	american	PROPN
dti-1304	196	2	thoracic	thoracic	NOUN
dti-1304	196	3	society	society	NOUN
dti-1304	196	4	;	;	PUNCT
dti-1304	196	5	european	european	ADJ
dti-1304	196	6	respiratory	respiratory	ADJ
dti-1304	196	7	society	society	NOUN
dti-1304	196	8	.	.	PUNCT
dti-1304	197	1	2002	2002	NUM
dti-1304	197	2	.	.	PUNCT
dti-1304	198	1	american	american	PROPN
dti-1304	198	2	thoracic	thoracic	PROPN
dti-1304	198	3	society	society	PROPN
dti-1304	198	4	/	/	SYM
dti-1304	198	5	european	european	ADJ
dti-1304	198	6	respiratory	respiratory	ADJ
dti-1304	198	7	society	society	NOUN
dti-1304	198	8	interstitial	interstitial	ADJ
dti-1304	198	9	multidisciplinary	multidisciplinary	ADJ
dti-1304	198	10	consensus	consensus	NOUN
dti-1304	198	11	classifi	classifi	PROPN
dti-1304	198	12	cation	cation	NOUN
dti-1304	198	13	of	of	ADP
dti-1304	198	14	the	the	DET
dti-1304	198	15	idiopathic	idiopathic	ADJ
dti-1304	198	16	interstitial	interstitial	ADJ
dti-1304	198	17	pneumonias	pneumonia	NOUN
dti-1304	198	18	.	.	PUNCT
dti-1304	199	1	am	be	AUX
dti-1304	199	2	.	.	PUNCT
dti-1304	200	1	j.	j.	PROPN
dti-1304	200	2	respir	respir	PROPN
dti-1304	200	3	.	.	PUNCT
dti-1304	201	1	crit	crit	PROPN
dti-1304	201	2	.	.	PUNCT
dti-1304	202	1	care	care	PROPN
dti-1304	202	2	med	med	PROPN
dti-1304	202	3	.	.	PUNCT
dti-1304	202	4	,	,	PUNCT
dti-1304	202	5	165:277–304	165:277–304	NUM
dti-1304	202	6	.	.	PUNCT
dti-1304	203	1	ando	ando	PROPN
dti-1304	203	2	,	,	PUNCT
dti-1304	203	3	w.	w.	PROPN
dti-1304	203	4	,	,	PUNCT
dti-1304	203	5	hashimoto	hashimoto	NOUN
dti-1304	203	6	,	,	PUNCT
dti-1304	203	7	j.	j.	PROPN
dti-1304	203	8	,	,	PUNCT
dti-1304	203	9	nampei	nampei	PROPN
dti-1304	203	10	,	,	PUNCT
dti-1304	203	11	a.	a.	PROPN
dti-1304	203	12	et	et	PROPN
dti-1304	203	13	al	al	PROPN
dti-1304	203	14	.	.	PROPN
dti-1304	203	15	2006	2006	NUM
dti-1304	203	16	.	.	PUNCT
dti-1304	204	1	imatinib	imatinib	NOUN
dti-1304	204	2	mesylate	mesylate	NOUN
dti-1304	204	3	inhibits	inhibit	VERB
dti-1304	204	4	osteoclastogenesis	osteoclastogenesis	NOUN
dti-1304	204	5	and	and	CCONJ
dti-1304	204	6	joint	joint	ADJ
dti-1304	204	7	destruction	destruction	NOUN
dti-1304	204	8	in	in	ADP
dti-1304	204	9	rats	rat	NOUN
dti-1304	204	10	with	with	ADP
dti-1304	204	11	collageninduced	collageninduce	VERB
dti-1304	204	12	arthritis	arthritis	NOUN
dti-1304	204	13	(	(	PUNCT
dti-1304	204	14	cia	cia	PROPN
dti-1304	204	15	)	)	PUNCT
dti-1304	204	16	.	.	PUNCT
dti-1304	205	1	j.	j.	PROPN
dti-1304	205	2	bone	bone	PROPN
dti-1304	205	3	miner	miner	NOUN
dti-1304	205	4	.	.	PUNCT
dti-1304	206	1	metab	metab	PROPN
dti-1304	206	2	.	.	PUNCT
dti-1304	207	1	,	,	PUNCT
dti-1304	207	2	24:274–82	24:274–82	PROPN
dti-1304	207	3	.	.	PUNCT
dti-1304	207	4	aono	aono	PROPN
dti-1304	207	5	,	,	PUNCT
dti-1304	207	6	y.	y.	PROPN
dti-1304	207	7	,	,	PUNCT
dti-1304	207	8	nishioka	nishioka	PROPN
dti-1304	207	9	,	,	PUNCT
dti-1304	207	10	y.	y.	PROPN
dti-1304	207	11	,	,	PUNCT
dti-1304	207	12	inamiya	inamiya	NOUN
dti-1304	207	13	,	,	PUNCT
dti-1304	207	14	m.	m.	NOUN
dti-1304	207	15	et	et	PROPN
dti-1304	207	16	al	al	PROPN
dti-1304	207	17	.	.	PROPN
dti-1304	207	18	2005	2005	NUM
dti-1304	207	19	.	.	PUNCT
dti-1304	208	1	imatinib	imatinib	NOUN
dti-1304	208	2	as	as	ADP
dti-1304	208	3	a	a	DET
dti-1304	208	4	novel	novel	ADJ
dti-1304	208	5	antifi	antifi	NOUN
dti-1304	208	6	brotic	brotic	ADJ
dti-1304	208	7	agent	agent	NOUN
dti-1304	208	8	in	in	ADP
dti-1304	208	9	bleomycin	bleomycin	PROPN
dti-1304	208	10	-	-	PUNCT
dti-1304	208	11	induced	induce	VERB
dti-1304	208	12	pulmonary	pulmonary	ADJ
dti-1304	208	13	fi	fi	NOUN
dti-1304	208	14	brosis	brosis	NOUN
dti-1304	208	15	in	in	ADP
dti-1304	208	16	mice	mouse	NOUN
dti-1304	208	17	.	.	PUNCT
dti-1304	209	1	am	be	AUX
dti-1304	209	2	.	.	PUNCT
dti-1304	210	1	j.	j.	PROPN
dti-1304	210	2	respir	respir	PROPN
dti-1304	210	3	.	.	PUNCT
dti-1304	211	1	crit	crit	PROPN
dti-1304	211	2	.	.	PUNCT
dti-1304	212	1	care	care	PROPN
dti-1304	212	2	med	med	PROPN
dti-1304	212	3	.	.	PROPN
dti-1304	212	4	,	,	PUNCT
dti-1304	212	5	171:1279–85	171:1279–85	NUM
dti-1304	212	6	.	.	PUNCT
dti-1304	213	1	baroni	baroni	PROPN
dti-1304	213	2	,	,	PUNCT
dti-1304	213	3	s.s	s.s	PROPN
dti-1304	213	4	.	.	PROPN
dti-1304	213	5	,	,	PUNCT
dti-1304	213	6	santillo	santillo	PROPN
dti-1304	213	7	,	,	PUNCT
dti-1304	213	8	m.	m.	NOUN
dti-1304	213	9	,	,	PUNCT
dti-1304	213	10	bevilacqua	bevilacqua	NOUN
dti-1304	213	11	,	,	PUNCT
dti-1304	213	12	f.	f.	PROPN
dti-1304	213	13	et	et	PROPN
dti-1304	213	14	al	al	PROPN
dti-1304	213	15	.	.	PROPN
dti-1304	213	16	2006	2006	NUM
dti-1304	213	17	.	.	PUNCT
dti-1304	214	1	stimulatory	stimulatory	ADJ
dti-1304	214	2	autoantibodies	autoantibody	NOUN
dti-1304	214	3	to	to	ADP
dti-1304	214	4	the	the	DET
dti-1304	214	5	pdgf	pdgf	ADJ
dti-1304	214	6	receptor	receptor	NOUN
dti-1304	214	7	in	in	ADP
dti-1304	214	8	systemic	systemic	ADJ
dti-1304	214	9	sclerosis	sclerosis	NOUN
dti-1304	214	10	.	.	PUNCT
dti-1304	215	1	n.	n.	PROPN
dti-1304	215	2	engl	engl	PROPN
dti-1304	215	3	.	.	PUNCT
dti-1304	216	1	j.	j.	PROPN
dti-1304	216	2	med	med	PROPN
dti-1304	216	3	.	.	PROPN
dti-1304	216	4	,	,	PUNCT
dti-1304	216	5	354:2667–76	354:2667–76	NUM
dti-1304	216	6	.	.	PUNCT
dti-1304	217	1	bouros	bouro	NOUN
dti-1304	217	2	,	,	PUNCT
dti-1304	217	3	d.	d.	PROPN
dti-1304	217	4	,	,	PUNCT
dti-1304	217	5	wells	wells	PROPN
dti-1304	217	6	,	,	PUNCT
dti-1304	217	7	a.u	a.u	PROPN
dti-1304	217	8	.	.	PROPN
dti-1304	217	9	,	,	PUNCT
dti-1304	217	10	nicholson	nicholson	PROPN
dti-1304	217	11	,	,	PUNCT
dti-1304	217	12	a.g	a.g	PROPN
dti-1304	217	13	.	.	PROPN
dti-1304	217	14	et	et	PROPN
dti-1304	217	15	al	al	PROPN
dti-1304	217	16	.	.	PROPN
dti-1304	217	17	2002	2002	NUM
dti-1304	217	18	.	.	PUNCT
dti-1304	218	1	histopathologic	histopathologic	ADJ
dti-1304	218	2	subsets	subset	NOUN
dti-1304	218	3	of	of	ADP
dti-1304	218	4	fi	fi	NOUN
dti-1304	218	5	brosing	brose	VERB
dti-1304	218	6	alveolitis	alveolitis	ADV
dti-1304	218	7	in	in	ADP
dti-1304	218	8	patients	patient	NOUN
dti-1304	218	9	with	with	ADP
dti-1304	218	10	systemic	systemic	ADJ
dti-1304	218	11	sclerosis	sclerosis	NOUN
dti-1304	218	12	and	and	CCONJ
dti-1304	218	13	their	their	PRON
dti-1304	218	14	relationship	relationship	NOUN
dti-1304	218	15	to	to	PART
dti-1304	218	16	outcome	outcome	VERB
dti-1304	218	17	.	.	PUNCT
dti-1304	219	1	am	be	AUX
dti-1304	219	2	.	.	PUNCT
dti-1304	220	1	j.	j.	PROPN
dti-1304	220	2	respir	respir	PROPN
dti-1304	220	3	.	.	PUNCT
dti-1304	221	1	crit	crit	PROPN
dti-1304	221	2	.	.	PUNCT
dti-1304	222	1	care	care	PROPN
dti-1304	222	2	med	med	PROPN
dti-1304	222	3	.	.	PROPN
dti-1304	222	4	,	,	PUNCT
dti-1304	222	5	165:1581–6	165:1581–6	NUM
dti-1304	222	6	.	.	PUNCT
dti-1304	223	1	braun	braun	NOUN
dti-1304	223	2	-	-	PUNCT
dti-1304	223	3	moscovici	moscovici	NOUN
dti-1304	223	4	,	,	PUNCT
dti-1304	223	5	y.	y.	PROPN
dti-1304	223	6	,	,	PUNCT
dti-1304	223	7	nahir	nahir	NOUN
dti-1304	223	8	,	,	PUNCT
dti-1304	223	9	a.m.	a.m.	PROPN
dti-1304	223	10	and	and	CCONJ
dti-1304	223	11	balbir	balbir	PROPN
dti-1304	223	12	-	-	PUNCT
dti-1304	223	13	gurman	gurman	NOUN
dti-1304	223	14	,	,	PUNCT
dti-1304	223	15	a.	a.	NOUN
dti-1304	223	16	2004	2004	NUM
dti-1304	223	17	.	.	PUNCT
dti-1304	224	1	endothelin	endothelin	PROPN
dti-1304	224	2	and	and	CCONJ
dti-1304	224	3	pulmonary	pulmonary	ADJ
dti-1304	224	4	arterial	arterial	ADJ
dti-1304	224	5	hypertension	hypertension	NOUN
dti-1304	224	6	.	.	PUNCT
dti-1304	225	1	semin	semin	PROPN
dti-1304	225	2	.	.	PUNCT
dti-1304	226	1	arthritis	arthritis	NOUN
dti-1304	226	2	rheum	rheum	PROPN
dti-1304	226	3	.	.	PUNCT
dti-1304	226	4	,	,	PUNCT
dti-1304	226	5	34:442–53	34:442–53	PROPN
dti-1304	226	6	.	.	PUNCT
dti-1304	227	1	capdeville	capdeville	PROPN
dti-1304	227	2	,	,	PUNCT
dti-1304	227	3	r.	r.	PROPN
dti-1304	227	4	,	,	PUNCT
dti-1304	227	5	buchdunger	buchdunger	NOUN
dti-1304	227	6	,	,	PUNCT
dti-1304	227	7	e.	e.	PROPN
dti-1304	227	8	,	,	PUNCT
dti-1304	227	9	zimmermann	zimmermann	PROPN
dti-1304	227	10	,	,	PUNCT
dti-1304	227	11	j.	j.	PROPN
dti-1304	227	12	and	and	CCONJ
dti-1304	227	13	matter	matter	NOUN
dti-1304	227	14	,	,	PUNCT
dti-1304	227	15	a.	a.	NOUN
dti-1304	227	16	2002	2002	NUM
dti-1304	227	17	.	.	PUNCT
dti-1304	228	1	glivec	glivec	PROPN
dti-1304	228	2	(	(	PUNCT
dti-1304	228	3	sti571	sti571	PROPN
dti-1304	228	4	,	,	PUNCT
dti-1304	228	5	imatinib	imatinib	NOUN
dti-1304	228	6	)	)	PUNCT
dti-1304	228	7	,	,	PUNCT
dti-1304	228	8	a	a	DET
dti-1304	228	9	rationally	rationally	ADV
dti-1304	228	10	developed	develop	VERB
dti-1304	228	11	,	,	PUNCT
dti-1304	228	12	targeted	targeted	ADJ
dti-1304	228	13	anticancer	anticancer	NOUN
dti-1304	228	14	drug	drug	NOUN
dti-1304	228	15	.	.	PUNCT
dti-1304	229	1	nat	nat	PROPN
dti-1304	229	2	.	.	PUNCT
dti-1304	230	1	rev	rev	PROPN
dti-1304	230	2	.	.	PROPN
dti-1304	230	3	drug	drug	NOUN
dti-1304	230	4	discov	discov	PROPN
dti-1304	230	5	.	.	PUNCT
dti-1304	230	6	,	,	PUNCT
dti-1304	230	7	1:493–502	1:493–502	PROPN
dti-1304	230	8	.	.	PUNCT
dti-1304	231	1	carroll	carroll	PROPN
dti-1304	231	2	,	,	PUNCT
dti-1304	231	3	m.	m.	NOUN
dti-1304	231	4	,	,	PUNCT
dti-1304	231	5	ohno	ohno	PROPN
dti-1304	231	6	-	-	PUNCT
dti-1304	231	7	jones	jones	PROPN
dti-1304	231	8	,	,	PUNCT
dti-1304	231	9	s.	s.	PROPN
dti-1304	231	10	,	,	PUNCT
dti-1304	231	11	tamura	tamura	PROPN
dti-1304	231	12	,	,	PUNCT
dti-1304	231	13	s.	s.	PROPN
dti-1304	231	14	et	et	PROPN
dti-1304	231	15	al	al	PROPN
dti-1304	231	16	.	.	PROPN
dti-1304	231	17	1997	1997	NUM
dti-1304	231	18	.	.	PUNCT
dti-1304	232	1	cgp57148	cgp57148	NOUN
dti-1304	232	2	,	,	PUNCT
dti-1304	232	3	a	a	DET
dti-1304	232	4	tyrosine	tyrosine	NOUN
dti-1304	232	5	kinase	kinase	NOUN
dti-1304	232	6	inhibitor	inhibitor	PROPN
dti-1304	232	7	,	,	PUNCT
dti-1304	232	8	inhibits	inhibit	VERB
dti-1304	232	9	the	the	DET
dti-1304	232	10	growth	growth	NOUN
dti-1304	232	11	of	of	ADP
dti-1304	232	12	cells	cell	NOUN
dti-1304	232	13	expressing	express	VERB
dti-1304	232	14	bcr	bcr	PROPN
dti-1304	232	15	-	-	PUNCT
dti-1304	232	16	abl	abl	PROPN
dti-1304	232	17	,	,	PUNCT
dti-1304	232	18	tel	tel	PROPN
dti-1304	232	19	-	-	PUNCT
dti-1304	232	20	abl	abl	NOUN
dti-1304	232	21	,	,	PUNCT
dti-1304	232	22	and	and	CCONJ
dti-1304	232	23	tel	tel	NOUN
dti-1304	232	24	-	-	PUNCT
dti-1304	232	25	pdgfr	pdgfr	ADJ
dti-1304	232	26	fusion	fusion	NOUN
dti-1304	232	27	proteins	protein	NOUN
dti-1304	232	28	.	.	PUNCT
dti-1304	233	1	blood	blood	NOUN
dti-1304	233	2	,	,	PUNCT
dti-1304	233	3	90:4947–52	90:4947–52	NUM
dti-1304	233	4	.	.	PUNCT
dti-1304	234	1	chaudhary	chaudhary	PROPN
dti-1304	234	2	,	,	PUNCT
dti-1304	234	3	n.i	n.i	PROPN
dti-1304	234	4	.	.	PROPN
dti-1304	234	5	,	,	PUNCT
dti-1304	234	6	schnapp	schnapp	NOUN
dti-1304	234	7	,	,	PUNCT
dti-1304	234	8	a.	a.	NOUN
dti-1304	234	9	and	and	CCONJ
dti-1304	234	10	park	park	NOUN
dti-1304	234	11	,	,	PUNCT
dti-1304	234	12	j.e	j.e	PROPN
dti-1304	234	13	.	.	PROPN
dti-1304	234	14	2006	2006	NUM
dti-1304	234	15	.	.	PUNCT
dti-1304	235	1	pharmacologic	pharmacologic	ADJ
dti-1304	235	2	differentiation	differentiation	NOUN
dti-1304	235	3	of	of	ADP
dti-1304	235	4	infl	infl	PROPN
dti-1304	235	5	ammation	ammation	NOUN
dti-1304	235	6	and	and	CCONJ
dti-1304	235	7	fi	fi	NOUN
dti-1304	235	8	brosis	brosis	NOUN
dti-1304	235	9	in	in	ADP
dti-1304	235	10	the	the	DET
dti-1304	235	11	rat	rat	NOUN
dti-1304	235	12	bleomycin	bleomycin	PROPN
dti-1304	235	13	model	model	PROPN
dti-1304	235	14	.	.	PUNCT
dti-1304	236	1	am	be	AUX
dti-1304	236	2	.	.	PUNCT
dti-1304	237	1	j.	j.	PROPN
dti-1304	237	2	respir	respir	PROPN
dti-1304	237	3	.	.	PUNCT
dti-1304	238	1	crit	crit	PROPN
dti-1304	238	2	.	.	PUNCT
dti-1304	239	1	care	care	PROPN
dti-1304	239	2	med	med	PROPN
dti-1304	239	3	.	.	PROPN
dti-1304	239	4	,	,	PUNCT
dti-1304	239	5	173:769–76	173:769–76	NUM
dti-1304	239	6	.	.	PUNCT
dti-1304	240	1	choy	choy	NOUN
dti-1304	240	2	,	,	PUNCT
dti-1304	240	3	e.h	e.h	PROPN
dti-1304	240	4	.	.	PROPN
dti-1304	240	5	and	and	CCONJ
dti-1304	240	6	panayi	panayi	NOUN
dti-1304	240	7	,	,	PUNCT
dti-1304	240	8	g.s	g.s	PROPN
dti-1304	240	9	.	.	PROPN
dti-1304	240	10	2001	2001	NUM
dti-1304	240	11	.	.	PUNCT
dti-1304	241	1	cytokine	cytokine	VERB
dti-1304	241	2	pathways	pathway	NOUN
dti-1304	241	3	and	and	CCONJ
dti-1304	241	4	joint	joint	PROPN
dti-1304	241	5	infl	infl	PROPN
dti-1304	241	6	ammation	ammation	NOUN
dti-1304	241	7	in	in	ADP
dti-1304	241	8	rheumatoid	rheumatoid	NOUN
dti-1304	241	9	arthritis	arthritis	NOUN
dti-1304	241	10	.	.	PUNCT
dti-1304	242	1	n.	n.	PROPN
dti-1304	242	2	eng	eng	PROPN
dti-1304	242	3	j.	j.	PROPN
dti-1304	242	4	med	med	PROPN
dti-1304	242	5	.	.	PROPN
dti-1304	242	6	,	,	PUNCT
dti-1304	243	1	344:907–16	344:907–16	NUM
dti-1304	243	2	.	.	PUNCT
dti-1304	244	1	daniels	daniels	PROPN
dti-1304	244	2	,	,	PUNCT
dti-1304	244	3	c.e	c.e	PROPN
dti-1304	244	4	.	.	PROPN
dti-1304	244	5	,	,	PUNCT
dti-1304	244	6	wikes	wikes	PROPN
dti-1304	244	7	,	,	PUNCT
dti-1304	244	8	m.c	m.c	PROPN
dti-1304	244	9	.	.	PROPN
dti-1304	244	10	,	,	PUNCT
dti-1304	244	11	edens	eden	NOUN
dti-1304	244	12	,	,	PUNCT
dti-1304	244	13	m.	m.	NOUN
dti-1304	244	14	et	et	PROPN
dti-1304	244	15	al	al	PROPN
dti-1304	244	16	.	.	PROPN
dti-1304	244	17	2004	2004	NUM
dti-1304	244	18	.	.	PUNCT
dti-1304	245	1	imatinib	imatinib	NOUN
dti-1304	245	2	mesylate	mesylate	VERB
dti-1304	245	3	inhibits	inhibit	VERB
dti-1304	245	4	the	the	DET
dti-1304	245	5	profi	profi	ADJ
dti-1304	245	6	brogenic	brogenic	ADJ
dti-1304	245	7	activity	activity	NOUN
dti-1304	245	8	of	of	ADP
dti-1304	245	9	tgf	tgf	PROPN
dti-1304	245	10	-	-	PUNCT
dti-1304	245	11	β	β	PROPN
dti-1304	245	12	and	and	CCONJ
dti-1304	245	13	prevents	prevent	VERB
dti-1304	245	14	bleomycin	bleomycin	PROPN
dti-1304	245	15	-	-	PUNCT
dti-1304	245	16	mediated	mediate	VERB
dti-1304	245	17	lung	lung	NOUN
dti-1304	245	18	fi	fi	NOUN
dti-1304	245	19	brosis	brosis	NOUN
dti-1304	245	20	.	.	PUNCT
dti-1304	246	1	j.	j.	PROPN
dti-1304	246	2	clin	clin	PROPN
dti-1304	246	3	.	.	PUNCT
dti-1304	247	1	invest	invest	PROPN
dti-1304	247	2	.	.	PUNCT
dti-1304	248	1	,	,	PUNCT
dti-1304	248	2	114:1308–16	114:1308–16	NUM
dti-1304	248	3	.	.	PUNCT
dti-1304	248	4	demetri	demetri	PROPN
dti-1304	248	5	,	,	PUNCT
dti-1304	248	6	g.d	g.d	PROPN
dti-1304	248	7	.	.	PROPN
dti-1304	248	8	,	,	PUNCT
dti-1304	248	9	von	von	PROPN
dti-1304	248	10	mehren	mehren	PROPN
dti-1304	248	11	,	,	PUNCT
dti-1304	248	12	m.	m.	NOUN
dti-1304	248	13	,	,	PUNCT
dti-1304	248	14	blanke	blanke	PROPN
dti-1304	248	15	,	,	PUNCT
dti-1304	248	16	c.d	c.d	PROPN
dti-1304	248	17	.	.	PROPN
dti-1304	248	18	et	et	PROPN
dti-1304	248	19	al	al	PROPN
dti-1304	248	20	.	.	PROPN
dti-1304	248	21	2002	2002	NUM
dti-1304	248	22	.	.	PUNCT
dti-1304	249	1	effi	effi	PROPN
dti-1304	249	2	cacy	cacy	PROPN
dti-1304	249	3	and	and	CCONJ
dti-1304	249	4	safety	safety	NOUN
dti-1304	249	5	of	of	ADP
dti-1304	249	6	imatinib	imatinib	NOUN
dti-1304	249	7	mesylate	mesylate	VERB
dti-1304	249	8	in	in	ADP
dti-1304	249	9	advanced	advanced	ADJ
dti-1304	249	10	gastrointestinal	gastrointestinal	ADJ
dti-1304	249	11	stromal	stromal	ADJ
dti-1304	249	12	tumors	tumor	NOUN
dti-1304	249	13	.	.	PUNCT
dti-1304	250	1	n.	n.	PROPN
dti-1304	250	2	engl	engl	PROPN
dti-1304	250	3	.	.	PUNCT
dti-1304	251	1	j.	j.	PROPN
dti-1304	251	2	med	med	PROPN
dti-1304	251	3	.	.	PROPN
dti-1304	251	4	,	,	PUNCT
dti-1304	251	5	347:472–80	347:472–80	PROPN
dti-1304	251	6	.	.	PUNCT
dti-1304	252	1	denton	denton	PROPN
dti-1304	252	2	,	,	PUNCT
dti-1304	252	3	c.p	c.p	PROPN
dti-1304	252	4	.	.	PROPN
dti-1304	252	5	,	,	PUNCT
dti-1304	252	6	humbert	humbert	PROPN
dti-1304	252	7	,	,	PUNCT
dti-1304	252	8	m.	m.	NOUN
dti-1304	252	9	,	,	PUNCT
dti-1304	252	10	rubin	rubin	PROPN
dti-1304	252	11	,	,	PUNCT
dti-1304	252	12	l.	l.	PROPN
dti-1304	252	13	and	and	CCONJ
dti-1304	252	14	black	black	ADJ
dti-1304	252	15	,	,	PUNCT
dti-1304	252	16	c.m	c.m	PROPN
dti-1304	252	17	.	.	PROPN
dti-1304	252	18	2006	2006	NUM
dti-1304	252	19	.	.	PUNCT
dti-1304	253	1	bosentan	bosentan	ADJ
dti-1304	253	2	treatment	treatment	NOUN
dti-1304	253	3	for	for	ADP
dti-1304	253	4	pulmonary	pulmonary	ADJ
dti-1304	253	5	arterial	arterial	NOUN
dti-1304	253	6	hypertension	hypertension	NOUN
dti-1304	253	7	related	relate	VERB
dti-1304	253	8	to	to	ADP
dti-1304	253	9	connective	connective	ADJ
dti-1304	253	10	tissue	tissue	NOUN
dti-1304	253	11	disease	disease	NOUN
dti-1304	253	12	:	:	PUNCT
dti-1304	253	13	a	a	DET
dti-1304	253	14	subgroup	subgroup	NOUN
dti-1304	253	15	analysis	analysis	NOUN
dti-1304	253	16	of	of	ADP
dti-1304	253	17	the	the	DET
dti-1304	253	18	pivotal	pivotal	ADJ
dti-1304	253	19	clinical	clinical	ADJ
dti-1304	253	20	trials	trial	NOUN
dti-1304	253	21	and	and	CCONJ
dti-1304	253	22	their	their	PRON
dti-1304	253	23	open	open	ADJ
dti-1304	253	24	-	-	PUNCT
dti-1304	253	25	label	label	NOUN
dti-1304	253	26	extensions	extension	NOUN
dti-1304	253	27	.	.	PUNCT
dti-1304	254	1	ann	ann	PROPN
dti-1304	254	2	.	.	PUNCT
dti-1304	254	3	rheum	rheum	PROPN
dti-1304	254	4	.	.	PUNCT
dti-1304	255	1	dis	dis	PROPN
dti-1304	255	2	.	.	PROPN
dti-1304	255	3	,	,	PUNCT
dti-1304	255	4	65:1336–40	65:1336–40	NUM
dti-1304	255	5	.	.	PUNCT
dti-1304	256	1	denton	denton	PROPN
dti-1304	256	2	,	,	PUNCT
dti-1304	256	3	c.r	c.r	PROPN
dti-1304	256	4	.	.	PROPN
dti-1304	256	5	,	,	PUNCT
dti-1304	256	6	merkel	merkel	PROPN
dti-1304	256	7	,	,	PUNCT
dti-1304	256	8	p.a	p.a	PROPN
dti-1304	256	9	.	.	PROPN
dti-1304	256	10	,	,	PUNCT
dti-1304	256	11	furst	furst	PROPN
dti-1304	256	12	,	,	PUNCT
dti-1304	256	13	d.e	d.e	PROPN
dti-1304	256	14	.	.	PROPN
dti-1304	256	15	et	et	PROPN
dti-1304	256	16	al	al	PROPN
dti-1304	256	17	.	.	PROPN
dti-1304	256	18	2007	2007	NUM
dti-1304	256	19	.	.	PUNCT
dti-1304	257	1	recombinant	recombinant	ADJ
dti-1304	257	2	human	human	ADJ
dti-1304	257	3	anti	anti	ADJ
dti-1304	257	4	-	-	ADJ
dti-1304	257	5	transforming	transforming	ADJ
dti-1304	257	6	growth	growth	NOUN
dti-1304	257	7	factor	factor	NOUN
dti-1304	257	8	β1	β1	NOUN
dti-1304	257	9	antibody	antibody	NOUN
dti-1304	257	10	therapy	therapy	NOUN
dti-1304	257	11	in	in	ADP
dti-1304	257	12	systemic	systemic	ADJ
dti-1304	257	13	sclerosis	sclerosis	NOUN
dti-1304	257	14	.	.	PUNCT
dti-1304	258	1	a	a	DET
dti-1304	258	2	multicenter	multicenter	NOUN
dti-1304	258	3	,	,	PUNCT
dti-1304	258	4	randomized	randomize	VERB
dti-1304	258	5	,	,	PUNCT
dti-1304	258	6	placebo	placebo	NOUN
dti-1304	258	7	-	-	PUNCT
dti-1304	258	8	controlled	control	VERB
dti-1304	258	9	phase	phase	NOUN
dti-1304	258	10	i	i	PRON
dti-1304	258	11	/	/	SYM
dti-1304	258	12	ii	ii	PROPN
dti-1304	258	13	trial	trial	NOUN
dti-1304	258	14	of	of	ADP
dti-1304	258	15	cat-192	cat-192	NOUN
dti-1304	258	16	.	.	PUNCT
dti-1304	259	1	arthritis	arthritis	NOUN
dti-1304	259	2	rheum	rheum	NOUN
dti-1304	259	3	.	.	PUNCT
dti-1304	259	4	,	,	PUNCT
dti-1304	259	5	56:323–33	56:323–33	NOUN
dti-1304	259	6	.	.	PUNCT
dti-1304	260	1	distler	distler	NOUN
dti-1304	260	2	,	,	PUNCT
dti-1304	260	3	j.h.w	j.h.w	PROPN
dti-1304	260	4	.	.	PUNCT
dti-1304	260	5	,	,	PUNCT
dti-1304	260	6	jüngel	jüngel	PROPN
dti-1304	260	7	,	,	PUNCT
dti-1304	260	8	a.	a.	PROPN
dti-1304	260	9	,	,	PUNCT
dti-1304	260	10	huber	huber	PROPN
dti-1304	260	11	,	,	PUNCT
dti-1304	260	12	l.c	l.c	PROPN
dti-1304	260	13	.	.	PROPN
dti-1304	260	14	et	et	PROPN
dti-1304	260	15	al	al	PROPN
dti-1304	260	16	.	.	PROPN
dti-1304	260	17	2007	2007	NUM
dti-1304	260	18	.	.	PUNCT
dti-1304	261	1	imatinib	imatinib	NOUN
dti-1304	261	2	mesylate	mesylate	NOUN
dti-1304	261	3	reduces	reduce	VERB
dti-1304	261	4	production	production	NOUN
dti-1304	261	5	of	of	ADP
dti-1304	261	6	extracellular	extracellular	ADJ
dti-1304	261	7	matrix	matrix	NOUN
dti-1304	261	8	and	and	CCONJ
dti-1304	261	9	prevents	prevent	VERB
dti-1304	261	10	development	development	NOUN
dti-1304	261	11	of	of	ADP
dti-1304	261	12	experimental	experimental	ADJ
dti-1304	261	13	dermal	dermal	NOUN
dti-1304	261	14	fi	fi	NOUN
dti-1304	261	15	brosis	brosis	NOUN
dti-1304	261	16	.	.	PUNCT
dti-1304	262	1	arthritis	arthritis	NOUN
dti-1304	262	2	rheum	rheum	NOUN
dti-1304	262	3	.	.	PUNCT
dti-1304	262	4	,	,	PUNCT
dti-1304	263	1	56:311–22	56:311–22	PROPN
dti-1304	263	2	.	.	PUNCT
dti-1304	264	1	druker	druker	NOUN
dti-1304	264	2	,	,	PUNCT
dti-1304	264	3	b.j	b.j	PROPN
dti-1304	264	4	.	.	PROPN
dti-1304	264	5	,	,	PUNCT
dti-1304	264	6	tamura	tamura	PROPN
dti-1304	264	7	,	,	PUNCT
dti-1304	264	8	s.	s.	PROPN
dti-1304	264	9	,	,	PUNCT
dti-1304	264	10	buchdunger	buchdunger	NOUN
dti-1304	264	11	,	,	PUNCT
dti-1304	264	12	e.	e.	PROPN
dti-1304	264	13	et	et	PROPN
dti-1304	264	14	al	al	PROPN
dti-1304	264	15	.	.	PROPN
dti-1304	264	16	1996	1996	NUM
dti-1304	264	17	.	.	PUNCT
dti-1304	265	1	effects	effect	NOUN
dti-1304	265	2	of	of	ADP
dti-1304	265	3	a	a	DET
dti-1304	265	4	selective	selective	ADJ
dti-1304	265	5	inhibitor	inhibitor	NOUN
dti-1304	265	6	of	of	ADP
dti-1304	265	7	the	the	DET
dti-1304	265	8	abl	abl	PROPN
dti-1304	265	9	tyrosine	tyrosine	PROPN
dti-1304	265	10	kinase	kinase	PROPN
dti-1304	265	11	on	on	ADP
dti-1304	265	12	the	the	DET
dti-1304	265	13	growth	growth	NOUN
dti-1304	265	14	of	of	ADP
dti-1304	265	15	bcr	bcr	PROPN
dti-1304	265	16	-	-	ADJ
dti-1304	265	17	abl	abl	ADJ
dti-1304	265	18	positive	positive	ADJ
dti-1304	265	19	cells	cell	NOUN
dti-1304	265	20	.	.	PUNCT
dti-1304	266	1	nat	nat	PROPN
dti-1304	266	2	.	.	PUNCT
dti-1304	267	1	med	med	PROPN
dti-1304	267	2	.	.	PROPN
dti-1304	267	3	,	,	PUNCT
dti-1304	267	4	2:561–6	2:561–6	NUM
dti-1304	267	5	.	.	PUNCT
dti-1304	267	6	druker	druker	NOUN
dti-1304	267	7	,	,	PUNCT
dti-1304	267	8	b.j	b.j	PROPN
dti-1304	267	9	.	.	PROPN
dti-1304	267	10	,	,	PUNCT
dti-1304	267	11	talpaz	talpaz	PROPN
dti-1304	267	12	,	,	PUNCT
dti-1304	267	13	m.	m.	NOUN
dti-1304	267	14	,	,	PUNCT
dti-1304	267	15	resta	resta	PROPN
dti-1304	267	16	,	,	PUNCT
dti-1304	267	17	d.j	d.j	PROPN
dti-1304	267	18	.	.	PROPN
dti-1304	267	19	et	et	PROPN
dti-1304	267	20	al	al	PROPN
dti-1304	267	21	.	.	PROPN
dti-1304	267	22	2001a	2001a	NOUN
dti-1304	267	23	.	.	PUNCT
dti-1304	268	1	effi	effi	PROPN
dti-1304	268	2	cacy	cacy	PROPN
dti-1304	268	3	and	and	CCONJ
dti-1304	268	4	safety	safety	NOUN
dti-1304	268	5	of	of	ADP
dti-1304	268	6	a	a	DET
dti-1304	268	7	specifi	specifi	PROPN
dti-1304	268	8	c	c	PROPN
dti-1304	268	9	inhibitor	inhibitor	NOUN
dti-1304	268	10	of	of	ADP
dti-1304	268	11	the	the	DET
dti-1304	268	12	bcr	bcr	PROPN
dti-1304	268	13	-	-	PUNCT
dti-1304	268	14	abl	abl	PROPN
dti-1304	268	15	tyrosine	tyrosine	PROPN
dti-1304	268	16	kinase	kinase	PROPN
dti-1304	268	17	in	in	ADP
dti-1304	268	18	chronic	chronic	ADJ
dti-1304	268	19	myeloid	myeloid	NOUN
dti-1304	268	20	leukemia	leukemia	NOUN
dti-1304	268	21	.	.	PUNCT
dti-1304	269	1	n.	n.	PROPN
dti-1304	269	2	engl	engl	PROPN
dti-1304	269	3	.	.	PUNCT
dti-1304	270	1	j.	j.	PROPN
dti-1304	270	2	med	med	PROPN
dti-1304	270	3	.	.	PROPN
dti-1304	270	4	,	,	PUNCT
dti-1304	270	5	344:1031–7	344:1031–7	X
dti-1304	270	6	.	.	PUNCT
dti-1304	271	1	druker	druker	NOUN
dti-1304	271	2	,	,	PUNCT
dti-1304	271	3	b.j	b.j	PROPN
dti-1304	271	4	.	.	PROPN
dti-1304	271	5	,	,	PUNCT
dti-1304	271	6	sawyers	sawyer	NOUN
dti-1304	271	7	,	,	PUNCT
dti-1304	271	8	c.l	c.l	PROPN
dti-1304	271	9	.	.	PROPN
dti-1304	271	10	,	,	PUNCT
dti-1304	271	11	kantarjian	kantarjian	PROPN
dti-1304	271	12	,	,	PUNCT
dti-1304	271	13	h.	h.	PROPN
dti-1304	271	14	et	et	PROPN
dti-1304	271	15	al	al	PROPN
dti-1304	271	16	.	.	PROPN
dti-1304	271	17	2001b	2001b	NUM
dti-1304	271	18	.	.	PUNCT
dti-1304	272	1	activity	activity	NOUN
dti-1304	272	2	of	of	ADP
dti-1304	272	3	a	a	DET
dti-1304	272	4	specifi	specifi	PROPN
dti-1304	272	5	c	c	PROPN
dti-1304	272	6	inhibitor	inhibitor	NOUN
dti-1304	272	7	of	of	ADP
dti-1304	272	8	the	the	DET
dti-1304	272	9	bcr	bcr	PROPN
dti-1304	272	10	-	-	PUNCT
dti-1304	272	11	abl	abl	PROPN
dti-1304	272	12	tyrosine	tyrosine	PROPN
dti-1304	272	13	kinase	kinase	PROPN
dti-1304	272	14	in	in	ADP
dti-1304	272	15	the	the	DET
dti-1304	272	16	blast	blast	NOUN
dti-1304	272	17	crisis	crisis	NOUN
dti-1304	272	18	of	of	ADP
dti-1304	272	19	chronic	chronic	ADJ
dti-1304	272	20	myeloid	myeloid	NOUN
dti-1304	272	21	leukemia	leukemia	PROPN
dti-1304	272	22	and	and	CCONJ
dti-1304	272	23	acute	acute	ADJ
dti-1304	272	24	lymphoblastic	lymphoblastic	ADJ
dti-1304	272	25	leukemia	leukemia	NOUN
dti-1304	272	26	with	with	ADP
dti-1304	272	27	the	the	DET
dti-1304	272	28	philadelphia	philadelphia	PROPN
dti-1304	272	29	chromosome	chromosome	NOUN
dti-1304	272	30	.	.	PUNCT
dti-1304	273	1	n.	n.	PROPN
dti-1304	273	2	engl	engl	PROPN
dti-1304	273	3	.	.	PUNCT
dti-1304	274	1	j.	j.	PROPN
dti-1304	274	2	med	med	PROPN
dti-1304	274	3	.	.	PROPN
dti-1304	274	4	,	,	PUNCT
dti-1304	274	5	344:1038–42	344:1038–42	PROPN
dti-1304	274	6	.	.	PUNCT
dti-1304	274	7	eklund	eklund	PROPN
dti-1304	274	8	,	,	PUNCT
dti-1304	274	9	k.k	k.k	PROPN
dti-1304	274	10	.	.	PROPN
dti-1304	274	11	and	and	CCONJ
dti-1304	274	12	joensuu	joensuu	PROPN
dti-1304	274	13	,	,	PUNCT
dti-1304	274	14	h.	h.	PROPN
dti-1304	274	15	2003	2003	NUM
dti-1304	274	16	.	.	PUNCT
dti-1304	275	1	treatment	treatment	NOUN
dti-1304	275	2	of	of	ADP
dti-1304	275	3	rheumatoid	rheumatoid	NOUN
dti-1304	275	4	arthritis	arthritis	NOUN
dti-1304	275	5	with	with	ADP
dti-1304	275	6	imatinib	imatinib	NOUN
dti-1304	275	7	mesylate	mesylate	NOUN
dti-1304	275	8	:	:	PUNCT
dti-1304	275	9	clinical	clinical	ADJ
dti-1304	275	10	improvement	improvement	NOUN
dti-1304	275	11	in	in	ADP
dti-1304	275	12	three	three	NUM
dti-1304	275	13	refractory	refractory	NOUN
dti-1304	275	14	cases	case	NOUN
dti-1304	275	15	.	.	PUNCT
dti-1304	276	1	ann	ann	PROPN
dti-1304	276	2	.	.	PROPN
dti-1304	276	3	med	med	PROPN
dti-1304	276	4	.	.	PROPN
dti-1304	276	5	,	,	PUNCT
dti-1304	276	6	35:362–7	35:362–7	X
dti-1304	276	7	.	.	PUNCT
dti-1304	277	1	firestein	firestein	PROPN
dti-1304	277	2	,	,	PUNCT
dti-1304	277	3	g.s	g.s	PROPN
dti-1304	277	4	.	.	PROPN
dti-1304	277	5	and	and	CCONJ
dti-1304	277	6	zvaifl	zvaifl	PROPN
dti-1304	277	7	er	er	INTJ
dti-1304	277	8	,	,	PUNCT
dti-1304	277	9	n.j	n.j	PROPN
dti-1304	277	10	.	.	PROPN
dti-1304	277	11	2002	2002	NUM
dti-1304	277	12	.	.	PUNCT
dti-1304	278	1	how	how	SCONJ
dti-1304	278	2	important	important	ADJ
dti-1304	278	3	are	be	AUX
dti-1304	278	4	t	t	NOUN
dti-1304	278	5	cells	cell	NOUN
dti-1304	278	6	in	in	ADP
dti-1304	278	7	chronic	chronic	ADJ
dti-1304	278	8	rheumatoid	rheumatoid	NOUN
dti-1304	278	9	synovitis	synovitis	PROPN
dti-1304	278	10	?	?	PUNCT
dti-1304	279	1	ii	ii	PROPN
dti-1304	279	2	.	.	PUNCT
dti-1304	280	1	t	t	PROPN
dti-1304	280	2	cell	cell	NOUN
dti-1304	280	3	-	-	PUNCT
dti-1304	280	4	independent	independent	ADJ
dti-1304	280	5	mechanisms	mechanism	NOUN
dti-1304	280	6	from	from	ADP
dti-1304	280	7	beginning	begin	VERB
dti-1304	280	8	to	to	ADP
dti-1304	280	9	end	end	NOUN
dti-1304	280	10	.	.	PUNCT
dti-1304	281	1	arthritis	arthritis	NOUN
dti-1304	281	2	rheum	rheum	NOUN
dti-1304	281	3	.	.	PUNCT
dti-1304	281	4	,	,	PUNCT
dti-1304	282	1	46:298–308	46:298–308	PROPN
dti-1304	282	2	.	.	PUNCT
dti-1304	283	1	floege	floege	PROPN
dti-1304	283	2	,	,	PUNCT
dti-1304	283	3	j.	j.	PROPN
dti-1304	283	4	,	,	PUNCT
dti-1304	283	5	ostendorf	ostendorf	PROPN
dti-1304	283	6	,	,	PUNCT
dti-1304	283	7	t.	t.	PROPN
dti-1304	283	8	,	,	PUNCT
dti-1304	283	9	janssen	janssen	PROPN
dti-1304	283	10	,	,	PUNCT
dti-1304	283	11	u.	u.	PROPN
dti-1304	283	12	et	et	PROPN
dti-1304	283	13	al	al	PROPN
dti-1304	283	14	.	.	PROPN
dti-1304	283	15	1999	1999	NUM
dti-1304	283	16	.	.	PUNCT
dti-1304	284	1	novel	novel	ADJ
dti-1304	284	2	approach	approach	NOUN
dti-1304	284	3	to	to	ADP
dti-1304	284	4	specifi	specifi	PROPN
dti-1304	284	5	c	c	PROPN
dti-1304	284	6	growth	growth	NOUN
dti-1304	284	7	factor	factor	NOUN
dti-1304	284	8	inhibition	inhibition	NOUN
dti-1304	284	9	in	in	ADP
dti-1304	284	10	vivo	vivo	NOUN
dti-1304	284	11	.	.	PUNCT
dti-1304	285	1	antagonism	antagonism	NOUN
dti-1304	285	2	of	of	ADP
dti-1304	285	3	platelet	platelet	NOUN
dti-1304	285	4	-	-	PUNCT
dti-1304	285	5	derived	derive	VERB
dti-1304	285	6	growth	growth	NOUN
dti-1304	285	7	factor	factor	NOUN
dti-1304	285	8	in	in	ADP
dti-1304	285	9	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	285	10	by	by	ADP
dti-1304	285	11	aptamers	aptamer	NOUN
dti-1304	285	12	.	.	PUNCT
dti-1304	286	1	am	be	AUX
dti-1304	286	2	.	.	PUNCT
dti-1304	287	1	j.	j.	PROPN
dti-1304	287	2	pathol	pathol	PROPN
dti-1304	287	3	.	.	PROPN
dti-1304	287	4	,	,	PUNCT
dti-1304	287	5	154:169–79	154:169–79	PROPN
dti-1304	287	6	.	.	PUNCT
dti-1304	288	1	ghofrani	ghofrani	PROPN
dti-1304	288	2	,	,	PUNCT
dti-1304	288	3	h.a	h.a	PROPN
dti-1304	288	4	.	.	PROPN
dti-1304	288	5	,	,	PUNCT
dti-1304	288	6	seeger	seeger	PROPN
dti-1304	288	7	,	,	PUNCT
dti-1304	288	8	w.	w.	PROPN
dti-1304	288	9	and	and	CCONJ
dti-1304	288	10	grimminger	grimminger	PROPN
dti-1304	288	11	,	,	PUNCT
dti-1304	288	12	f.	f.	PROPN
dti-1304	288	13	2005	2005	NUM
dti-1304	288	14	.	.	PUNCT
dti-1304	289	1	imatinib	imatinib	NOUN
dti-1304	289	2	for	for	ADP
dti-1304	289	3	the	the	DET
dti-1304	289	4	treatment	treatment	NOUN
dti-1304	289	5	of	of	ADP
dti-1304	289	6	pulmonary	pulmonary	ADJ
dti-1304	289	7	arterial	arterial	ADJ
dti-1304	289	8	hypertension	hypertension	NOUN
dti-1304	289	9	.	.	PUNCT
dti-1304	290	1	n.	n.	PROPN
dti-1304	290	2	engl	engl	PROPN
dti-1304	290	3	.	.	PUNCT
dti-1304	291	1	j.	j.	PROPN
dti-1304	291	2	med	med	PROPN
dti-1304	291	3	.	.	PROPN
dti-1304	291	4	,	,	PUNCT
dti-1304	291	5	353:1412–3	353:1412–3	NUM
dti-1304	291	6	.	.	PUNCT
dti-1304	292	1	gilbert	gilbert	PROPN
dti-1304	292	2	,	,	PUNCT
dti-1304	292	3	r.e	r.e	PROPN
dti-1304	292	4	.	.	PROPN
dti-1304	292	5	,	,	PUNCT
dti-1304	292	6	kelly	kelly	PROPN
dti-1304	292	7	,	,	PUNCT
dti-1304	292	8	d.j	d.j	PROPN
dti-1304	292	9	.	.	PROPN
dti-1304	292	10	,	,	PUNCT
dti-1304	292	11	mckay	mckay	PROPN
dti-1304	292	12	,	,	PUNCT
dti-1304	292	13	t.	t.	PROPN
dti-1304	292	14	et	et	PROPN
dti-1304	292	15	al	al	PROPN
dti-1304	292	16	.	.	PROPN
dti-1304	292	17	2001	2001	NUM
dti-1304	292	18	.	.	PUNCT
dti-1304	293	1	pdgf	pdgf	PROPN
dti-1304	293	2	signal	signal	NOUN
dti-1304	293	3	transduction	transduction	NOUN
dti-1304	293	4	inhibition	inhibition	NOUN
dti-1304	293	5	ameliorates	ameliorate	VERB
dti-1304	293	6	experimental	experimental	ADJ
dti-1304	293	7	mesangial	mesangial	ADJ
dti-1304	293	8	proliferative	proliferative	ADJ
dti-1304	293	9	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	293	10	.	.	PUNCT
dti-1304	294	1	kidney	kidney	NOUN
dti-1304	294	2	int	int	PROPN
dti-1304	294	3	.	.	PUNCT
dti-1304	294	4	,	,	PUNCT
dti-1304	294	5	59:1324–32	59:1324–32	NUM
dti-1304	294	6	.	.	PUNCT
dti-1304	295	1	heldin	heldin	PROPN
dti-1304	295	2	,	,	PUNCT
dti-1304	295	3	c	c	PROPN
dti-1304	295	4	-	-	PUNCT
dti-1304	295	5	h.	h.	PROPN
dti-1304	295	6	and	and	CCONJ
dti-1304	295	7	westermark	westermark	PROPN
dti-1304	295	8	,	,	PUNCT
dti-1304	295	9	b.	b.	PROPN
dti-1304	295	10	1999	1999	NUM
dti-1304	295	11	.	.	PUNCT
dti-1304	296	1	mechanism	mechanism	NOUN
dti-1304	296	2	of	of	ADP
dti-1304	296	3	action	action	NOUN
dti-1304	296	4	and	and	CCONJ
dti-1304	296	5	in	in	ADP
dti-1304	296	6	vivo	vivo	ADJ
dti-1304	296	7	role	role	NOUN
dti-1304	296	8	of	of	ADP
dti-1304	296	9	platelet	platelet	NOUN
dti-1304	296	10	-	-	PUNCT
dti-1304	296	11	derived	derive	VERB
dti-1304	296	12	growth	growth	NOUN
dti-1304	296	13	factor	factor	NOUN
dti-1304	296	14	.	.	PUNCT
dti-1304	297	1	physiol	physiol	PROPN
dti-1304	297	2	.	.	PUNCT
dti-1304	298	1	rev	rev	PROPN
dti-1304	298	2	.	.	PROPN
dti-1304	298	3	,	,	PUNCT
dti-1304	298	4	79:1283–316	79:1283–316	PROPN
dti-1304	298	5	.	.	PUNCT
dti-1304	298	6	imamura	imamura	PROPN
dti-1304	298	7	,	,	PUNCT
dti-1304	298	8	f.	f.	PROPN
dti-1304	298	9	,	,	PUNCT
dti-1304	298	10	aono	aono	PROPN
dti-1304	298	11	,	,	PUNCT
dti-1304	298	12	h.	h.	PROPN
dti-1304	298	13	,	,	PUNCT
dti-1304	298	14	hasunuma	hasunuma	PROPN
dti-1304	298	15	,	,	PUNCT
dti-1304	298	16	t.	t.	PROPN
dti-1304	298	17	et	et	PROPN
dti-1304	298	18	al	al	PROPN
dti-1304	298	19	.	.	PROPN
dti-1304	298	20	1998	1998	NUM
dti-1304	298	21	.	.	PUNCT
dti-1304	299	1	monoclonal	monoclonal	NOUN
dti-1304	299	2	expansion	expansion	NOUN
dti-1304	299	3	of	of	ADP
dti-1304	299	4	synoviocytes	synoviocyte	NOUN
dti-1304	299	5	in	in	ADP
dti-1304	299	6	rheumatoid	rheumatoid	NOUN
dti-1304	299	7	arthritis	arthritis	NOUN
dti-1304	299	8	.	.	PUNCT
dti-1304	300	1	arthritis	arthritis	NOUN
dti-1304	300	2	rheum	rheum	NOUN
dti-1304	300	3	.	.	PUNCT
dti-1304	300	4	,	,	PUNCT
dti-1304	300	5	41:1979–86	41:1979–86	PROPN
dti-1304	300	6	.	.	PUNCT
dti-1304	301	1	johnson	johnson	PROPN
dti-1304	301	2	,	,	PUNCT
dti-1304	301	3	r.j	r.j	PROPN
dti-1304	301	4	.	.	PROPN
dti-1304	301	5	,	,	PUNCT
dti-1304	301	6	raines	raines	PROPN
dti-1304	301	7	,	,	PUNCT
dti-1304	301	8	e.w	e.w	PROPN
dti-1304	301	9	.	.	PROPN
dti-1304	301	10	,	,	PUNCT
dti-1304	301	11	floege	floege	PROPN
dti-1304	301	12	,	,	PUNCT
dti-1304	301	13	j.	j.	PROPN
dti-1304	301	14	et	et	PROPN
dti-1304	301	15	al	al	PROPN
dti-1304	301	16	.	.	PROPN
dti-1304	301	17	1992	1992	NUM
dti-1304	301	18	.	.	PUNCT
dti-1304	302	1	inhibition	inhibition	NOUN
dti-1304	302	2	of	of	ADP
dti-1304	302	3	mesangial	mesangial	ADJ
dti-1304	302	4	cell	cell	NOUN
dti-1304	302	5	proliferation	proliferation	NOUN
dti-1304	302	6	and	and	CCONJ
dti-1304	302	7	matrix	matrix	NOUN
dti-1304	302	8	expression	expression	NOUN
dti-1304	302	9	in	in	ADP
dti-1304	302	10	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	302	11	in	in	ADP
dti-1304	302	12	the	the	DET
dti-1304	302	13	rat	rat	NOUN
dti-1304	302	14	by	by	ADP
dti-1304	302	15	antibody	antibody	NOUN
dti-1304	302	16	to	to	ADP
dti-1304	302	17	platelet	platelet	NOUN
dti-1304	302	18	-	-	PUNCT
dti-1304	302	19	derived	derive	VERB
dti-1304	302	20	growth	growth	NOUN
dti-1304	302	21	factor	factor	NOUN
dti-1304	302	22	.	.	PUNCT
dti-1304	303	1	j.	j.	PROPN
dti-1304	303	2	exp	exp	PROPN
dti-1304	303	3	.	.	PROPN
dti-1304	303	4	med	med	PROPN
dti-1304	303	5	.	.	PROPN
dti-1304	303	6	,	,	PUNCT
dti-1304	303	7	175:1413–6	175:1413–6	NUM
dti-1304	303	8	.	.	PUNCT
dti-1304	304	1	kameda	kameda	PROPN
dti-1304	304	2	,	,	PUNCT
dti-1304	304	3	h.	h.	PROPN
dti-1304	304	4	,	,	PUNCT
dti-1304	304	5	risinger	risinger	NOUN
dti-1304	304	6	,	,	PUNCT
dti-1304	304	7	j.i	j.i	PROPN
dti-1304	304	8	.	.	PROPN
dti-1304	304	9	,	,	PUNCT
dti-1304	304	10	han	han	PROPN
dti-1304	304	11	,	,	PUNCT
dti-1304	304	12	b	b	PROPN
dti-1304	304	13	-	-	PUNCT
dti-1304	304	14	b.	b.	PROPN
dti-1304	304	15	et	et	PROPN
dti-1304	304	16	al	al	PROPN
dti-1304	304	17	.	.	PROPN
dti-1304	304	18	2001	2001	NUM
dti-1304	304	19	.	.	PUNCT
dti-1304	305	1	expression	expression	NOUN
dti-1304	305	2	of	of	ADP
dti-1304	305	3	gab1	gab1	ADV
dti-1304	305	4	lacking	lack	VERB
dti-1304	305	5	the	the	DET
dti-1304	305	6	preckstrin	preckstrin	NOUN
dti-1304	305	7	homology	homology	NOUN
dti-1304	305	8	domain	domain	NOUN
dti-1304	305	9	is	be	AUX
dti-1304	305	10	associated	associate	VERB
dti-1304	305	11	with	with	ADP
dti-1304	305	12	neoplastic	neoplastic	ADJ
dti-1304	305	13	progression	progression	NOUN
dti-1304	305	14	.	.	PUNCT
dti-1304	306	1	mol	mol	PROPN
dti-1304	306	2	.	.	PROPN
dti-1304	306	3	cell	cell	NOUN
dti-1304	306	4	.	.	PUNCT
dti-1304	307	1	biol	biol	PROPN
dti-1304	307	2	.	.	PUNCT
dti-1304	307	3	,	,	PUNCT
dti-1304	308	1	21:6895–905	21:6895–905	PROPN
dti-1304	308	2	.	.	PUNCT
dti-1304	309	1	kameda	kameda	PROPN
dti-1304	309	2	,	,	PUNCT
dti-1304	309	3	h.	h.	PROPN
dti-1304	309	4	,	,	PUNCT
dti-1304	309	5	nagasawa	nagasawa	PROPN
dti-1304	309	6	,	,	PUNCT
dti-1304	309	7	h.	h.	PROPN
dti-1304	309	8	,	,	PUNCT
dti-1304	309	9	ogawa	ogawa	PROPN
dti-1304	309	10	,	,	PUNCT
dti-1304	309	11	h.	h.	PROPN
dti-1304	309	12	et	et	PROPN
dti-1304	309	13	al	al	PROPN
dti-1304	309	14	.	.	PROPN
dti-1304	309	15	2005	2005	NUM
dti-1304	309	16	.	.	PUNCT
dti-1304	310	1	combination	combination	NOUN
dti-1304	310	2	therapy	therapy	NOUN
dti-1304	310	3	with	with	ADP
dti-1304	310	4	corticosteroids	corticosteroid	NOUN
dti-1304	310	5	,	,	PUNCT
dti-1304	310	6	cyclosporine	cyclosporine	VERB
dti-1304	310	7	a	a	PRON
dti-1304	310	8	,	,	PUNCT
dti-1304	310	9	and	and	CCONJ
dti-1304	310	10	intravenous	intravenous	ADJ
dti-1304	310	11	pulse	pulse	NOUN
dti-1304	310	12	cyclophosphamide	cyclophosphamide	NOUN
dti-1304	310	13	for	for	ADP
dti-1304	310	14	acute	acute	ADJ
dti-1304	310	15	/	/	SYM
dti-1304	310	16	subacute	subacute	ADJ
dti-1304	310	17	interstitial	interstitial	ADJ
dti-1304	310	18	pneumonia	pneumonia	NOUN
dti-1304	310	19	in	in	ADP
dti-1304	310	20	patients	patient	NOUN
dti-1304	310	21	with	with	ADP
dti-1304	310	22	dermatomyositis	dermatomyositis	PROPN
dti-1304	310	23	.	.	PUNCT
dti-1304	311	1	j.	j.	PROPN
dti-1304	311	2	rheumatol	rheumatol	PROPN
dti-1304	311	3	.	.	PUNCT
dti-1304	311	4	,	,	PUNCT
dti-1304	311	5	32:1719–26	32:1719–26	NUM
dti-1304	311	6	.	.	PUNCT
dti-1304	312	1	kameda	kameda	PROPN
dti-1304	312	2	,	,	PUNCT
dti-1304	312	3	h.	h.	PROPN
dti-1304	312	4	and	and	CCONJ
dti-1304	312	5	takeuchi	takeuchi	PROPN
dti-1304	312	6	,	,	PUNCT
dti-1304	312	7	t.	t.	PROPN
dti-1304	312	8	2006	2006	NUM
dti-1304	312	9	.	.	PUNCT
dti-1304	313	1	recent	recent	ADJ
dti-1304	313	2	advances	advance	NOUN
dti-1304	313	3	in	in	ADP
dti-1304	313	4	the	the	DET
dti-1304	313	5	treatment	treatment	NOUN
dti-1304	313	6	of	of	ADP
dti-1304	313	7	interstitial	interstitial	ADJ
dti-1304	313	8	lung	lung	NOUN
dti-1304	313	9	disease	disease	NOUN
dti-1304	313	10	in	in	ADP
dti-1304	313	11	patients	patient	NOUN
dti-1304	313	12	with	with	ADP
dti-1304	313	13	polymyositis	polymyositis	PROPN
dti-1304	313	14	/	/	SYM
dti-1304	313	15	dermatomyositis	dermatomyositis	PROPN
dti-1304	313	16	.	.	PUNCT
dti-1304	314	1	endocr	endocr	PROPN
dti-1304	314	2	.	.	PUNCT
dti-1304	315	1	metab	metab	PROPN
dti-1304	315	2	.	.	PUNCT
dti-1304	316	1	immune	immune	PROPN
dti-1304	316	2	.	.	PUNCT
dti-1304	317	1	disord	disord	NOUN
dti-1304	317	2	.	.	PUNCT
dti-1304	318	1	drug	drug	NOUN
dti-1304	318	2	targets	target	NOUN
dti-1304	318	3	,	,	PUNCT
dti-1304	318	4	6:409–15	6:409–15	NOUN
dti-1304	318	5	.	.	NOUN
dti-1304	318	6	247	247	NUM
dti-1304	318	7	pdgf	pdgf	NOUN
dti-1304	318	8	as	as	ADP
dti-1304	318	9	a	a	DET
dti-1304	318	10	target	target	NOUN
dti-1304	318	11	for	for	ADP
dti-1304	318	12	systemic	systemic	ADJ
dti-1304	318	13	autoimmune	autoimmune	ADJ
dti-1304	318	14	diseases	disease	NOUN
dti-1304	318	15	drug	drug	NOUN
dti-1304	318	16	target	target	NOUN
dti-1304	318	17	insights	insight	NOUN
dti-1304	318	18	2007:2	2007:2	ADJ
dti-1304	318	19	kameda	kameda	PROPN
dti-1304	318	20	,	,	PUNCT
dti-1304	318	21	h.	h.	PROPN
dti-1304	318	22	,	,	PUNCT
dti-1304	318	23	ishigami	ishigami	NOUN
dti-1304	318	24	,	,	PUNCT
dti-1304	318	25	h.	h.	PROPN
dti-1304	318	26	,	,	PUNCT
dti-1304	318	27	suzuki	suzuki	PROPN
dti-1304	318	28	,	,	PUNCT
dti-1304	318	29	m.	m.	NOUN
dti-1304	318	30	et	et	PROPN
dti-1304	318	31	al	al	PROPN
dti-1304	318	32	.	.	PROPN
dti-1304	318	33	2006	2006	NUM
dti-1304	318	34	.	.	PUNCT
dti-1304	319	1	imatinib	imatinib	NOUN
dti-1304	319	2	mesylate	mesylate	VERB
dti-1304	319	3	inhibits	inhibit	VERB
dti-1304	319	4	proliferation	proliferation	NOUN
dti-1304	319	5	of	of	ADP
dti-1304	319	6	rheumatoid	rheumatoid	NOUN
dti-1304	319	7	synovial	synovial	ADJ
dti-1304	319	8	fibroblast	fibroblast	ADJ
dti-1304	319	9	-	-	PUNCT
dti-1304	319	10	like	like	ADJ
dti-1304	319	11	cells	cell	NOUN
dti-1304	319	12	and	and	CCONJ
dti-1304	319	13	phosphorylation	phosphorylation	NOUN
dti-1304	319	14	of	of	ADP
dti-1304	319	15	gab	gab	ADJ
dti-1304	319	16	adapter	adapter	NOUN
dti-1304	319	17	proteins	protein	NOUN
dti-1304	319	18	activated	activate	VERB
dti-1304	319	19	by	by	ADP
dti-1304	319	20	platelet	platelet	ADJ
dti-1304	319	21	-	-	PUNCT
dti-1304	319	22	derived	derive	VERB
dti-1304	319	23	growth	growth	NOUN
dti-1304	319	24	factor	factor	NOUN
dti-1304	319	25	.	.	PUNCT
dti-1304	320	1	clin	clin	PROPN
dti-1304	320	2	.	.	PUNCT
dti-1304	321	1	exp	exp	PROPN
dti-1304	321	2	.	.	PUNCT
dti-1304	321	3	immunol	immunol	PROPN
dti-1304	321	4	.	.	PUNCT
dti-1304	321	5	,	,	PUNCT
dti-1304	322	1	144:335–41	144:335–41	NUM
dti-1304	322	2	.	.	PUNCT
dti-1304	323	1	kondo	kondo	PROPN
dti-1304	323	2	,	,	PUNCT
dti-1304	323	3	h.	h.	PROPN
dti-1304	323	4	2001	2001	NUM
dti-1304	323	5	.	.	PUNCT
dti-1304	324	1	vascular	vascular	ADJ
dti-1304	324	2	disease	disease	NOUN
dti-1304	324	3	in	in	ADP
dti-1304	324	4	mixed	mixed	ADJ
dti-1304	324	5	connective	connective	ADJ
dti-1304	324	6	tissue	tissue	NOUN
dti-1304	324	7	disease	disease	NOUN
dti-1304	324	8	(	(	PUNCT
dti-1304	324	9	mctd	mctd	NOUN
dti-1304	324	10	)	)	PUNCT
dti-1304	324	11	.	.	PUNCT
dti-1304	325	1	intern	intern	PROPN
dti-1304	325	2	.	.	PUNCT
dti-1304	326	1	med	med	PROPN
dti-1304	326	2	.	.	PROPN
dti-1304	326	3	,	,	PUNCT
dti-1304	326	4	40:1176	40:1176	PROPN
dti-1304	326	5	.	.	PUNCT
dti-1304	327	1	lafyatis	lafyatis	PROPN
dti-1304	327	2	,	,	PUNCT
dti-1304	327	3	r.	r.	PROPN
dti-1304	327	4	,	,	PUNCT
dti-1304	327	5	remmers	remmer	NOUN
dti-1304	327	6	,	,	PUNCT
dti-1304	327	7	e.f	e.f	PROPN
dti-1304	327	8	.	.	PROPN
dti-1304	327	9	,	,	PUNCT
dti-1304	327	10	roberts	roberts	PROPN
dti-1304	327	11	,	,	PUNCT
dti-1304	327	12	a.b	a.b	PROPN
dti-1304	327	13	.	.	PROPN
dti-1304	327	14	et	et	PROPN
dti-1304	327	15	al	al	PROPN
dti-1304	327	16	.	.	PROPN
dti-1304	327	17	1989	1989	NUM
dti-1304	327	18	.	.	PUNCT
dti-1304	328	1	anchorageindependent	anchorageindependent	ADJ
dti-1304	328	2	growth	growth	NOUN
dti-1304	328	3	of	of	ADP
dti-1304	328	4	synoviocytes	synoviocyte	NOUN
dti-1304	328	5	from	from	ADP
dti-1304	328	6	arthritic	arthritic	ADJ
dti-1304	328	7	and	and	CCONJ
dti-1304	328	8	normal	normal	ADJ
dti-1304	328	9	joints	joint	NOUN
dti-1304	328	10	.	.	PUNCT
dti-1304	329	1	stimulation	stimulation	NOUN
dti-1304	329	2	by	by	ADP
dti-1304	329	3	exogenous	exogenous	ADJ
dti-1304	329	4	platelet	platelet	NOUN
dti-1304	329	5	-	-	PUNCT
dti-1304	329	6	derived	derive	VERB
dti-1304	329	7	growth	growth	NOUN
dti-1304	329	8	factor	factor	NOUN
dti-1304	329	9	and	and	CCONJ
dti-1304	329	10	inhibition	inhibition	NOUN
dti-1304	329	11	by	by	ADP
dti-1304	329	12	transforming	transform	VERB
dti-1304	329	13	growth	growth	NOUN
dti-1304	329	14	factor	factor	NOUN
dti-1304	329	15	-	-	PUNCT
dti-1304	329	16	beta	beta	NOUN
dti-1304	329	17	and	and	CCONJ
dti-1304	329	18	retinoids	retinoid	NOUN
dti-1304	329	19	.	.	PUNCT
dti-1304	330	1	j.	j.	PROPN
dti-1304	330	2	clin	clin	PROPN
dti-1304	330	3	.	.	PUNCT
dti-1304	331	1	invest	invest	PROPN
dti-1304	331	2	.	.	PUNCT
dti-1304	331	3	,	,	PUNCT
dti-1304	331	4	83:1267–76	83:1267–76	NUM
dti-1304	331	5	.	.	PUNCT
dti-1304	332	1	matsuda	matsuda	PROPN
dti-1304	332	2	,	,	PUNCT
dti-1304	332	3	m.	m.	NOUN
dti-1304	332	4	,	,	PUNCT
dti-1304	332	5	shikata	shikata	PROPN
dti-1304	332	6	,	,	PUNCT
dti-1304	332	7	k.	k.	PROPN
dti-1304	332	8	,	,	PUNCT
dti-1304	332	9	makino	makino	PROPN
dti-1304	332	10	,	,	PUNCT
dti-1304	332	11	h.	h.	PROPN
dti-1304	332	12	et	et	PROPN
dti-1304	332	13	al	al	PROPN
dti-1304	332	14	.	.	PROPN
dti-1304	332	15	1997	1997	NUM
dti-1304	332	16	.	.	PUNCT
dti-1304	333	1	gene	gene	NOUN
dti-1304	333	2	expression	expression	NOUN
dti-1304	333	3	of	of	ADP
dti-1304	333	4	pdgf	pdgf	NOUN
dti-1304	333	5	and	and	CCONJ
dti-1304	333	6	pdgf	pdgf	ADJ
dti-1304	333	7	receptor	receptor	NOUN
dti-1304	333	8	in	in	ADP
dti-1304	333	9	various	various	ADJ
dti-1304	333	10	forms	form	NOUN
dti-1304	333	11	of	of	ADP
dti-1304	333	12	glomerulonephritis	glomerulonephritis	NOUN
dti-1304	333	13	.	.	PUNCT
dti-1304	334	1	am	be	AUX
dti-1304	334	2	.	.	PUNCT
dti-1304	335	1	j.	j.	PROPN
dti-1304	335	2	nephrol	nephrol	PROPN
dti-1304	335	3	.	.	PROPN
dti-1304	335	4	,	,	PUNCT
dti-1304	335	5	17:25–31	17:25–31	NUM
dti-1304	335	6	.	.	PUNCT
dti-1304	336	1	miyachi	miyachi	PROPN
dti-1304	336	2	,	,	PUNCT
dti-1304	336	3	k.	k.	PROPN
dti-1304	336	4	,	,	PUNCT
dti-1304	336	5	ihara	ihara	PROPN
dti-1304	336	6	,	,	PUNCT
dti-1304	336	7	a.	a.	PROPN
dti-1304	336	8	,	,	PUNCT
dti-1304	336	9	hankins	hankins	PROPN
dti-1304	336	10	,	,	PUNCT
dti-1304	336	11	r.w	r.w	PROPN
dti-1304	336	12	.	.	PROPN
dti-1304	336	13	et	et	PROPN
dti-1304	337	1	al	al	PROPN
dti-1304	337	2	.	.	PROPN
dti-1304	337	3	2003	2003	NUM
dti-1304	337	4	.	.	PUNCT
dti-1304	338	1	effi	effi	PROPN
dti-1304	338	2	cacy	cacy	NOUN
dti-1304	338	3	of	of	ADP
dti-1304	338	4	imatinib	imatinib	NOUN
dti-1304	338	5	mesylate	mesylate	NOUN
dti-1304	338	6	(	(	PUNCT
dti-1304	338	7	sti571	sti571	NOUN
dti-1304	338	8	)	)	PUNCT
dti-1304	338	9	treatment	treatment	NOUN
dti-1304	338	10	for	for	ADP
dti-1304	338	11	a	a	DET
dti-1304	338	12	patient	patient	NOUN
dti-1304	338	13	with	with	ADP
dti-1304	338	14	rheumatoid	rheumatoid	NOUN
dti-1304	338	15	arthritis	arthritis	NOUN
dti-1304	338	16	developing	develop	VERB
dti-1304	338	17	chronic	chronic	ADJ
dti-1304	338	18	myelogenous	myelogenous	ADJ
dti-1304	338	19	leukemia	leukemia	NOUN
dti-1304	338	20	.	.	PUNCT
dti-1304	339	1	clin	clin	PROPN
dti-1304	339	2	.	.	PUNCT
dti-1304	340	1	rheumatol	rheumatol	PROPN
dti-1304	340	2	.	.	PUNCT
dti-1304	341	1	,	,	PUNCT
dti-1304	341	2	22:329–32	22:329–32	NOUN
dti-1304	341	3	.	.	PUNCT
dti-1304	342	1	müller	müller	PROPN
dti-1304	342	2	-	-	PUNCT
dti-1304	342	3	ladner	ladner	PROPN
dti-1304	342	4	,	,	PUNCT
dti-1304	342	5	u.	u.	PROPN
dti-1304	342	6	,	,	PUNCT
dti-1304	342	7	kriegsmann	kriegsmann	PROPN
dti-1304	342	8	,	,	PUNCT
dti-1304	342	9	j.	j.	PROPN
dti-1304	342	10	,	,	PUNCT
dti-1304	342	11	gay	gay	PROPN
dti-1304	342	12	,	,	PUNCT
dti-1304	342	13	r.e	r.e	PROPN
dti-1304	342	14	.	.	PROPN
dti-1304	342	15	et	et	PROPN
dti-1304	342	16	al	al	PROPN
dti-1304	342	17	.	.	PROPN
dti-1304	342	18	1995	1995	NUM
dti-1304	342	19	.	.	PUNCT
dti-1304	343	1	oncogenes	oncogene	NOUN
dti-1304	343	2	in	in	ADP
dti-1304	343	3	rheumatoid	rheumatoid	NOUN
dti-1304	343	4	arthritis	arthritis	NOUN
dti-1304	343	5	.	.	PUNCT
dti-1304	344	1	rheum	rheum	PROPN
dti-1304	344	2	dis	dis	PROPN
dti-1304	344	3	.	.	PUNCT
dti-1304	345	1	clin	clin	PROPN
dti-1304	345	2	.	.	PUNCT
dti-1304	346	1	north	north	PROPN
dti-1304	346	2	am	am	PROPN
dti-1304	346	3	.	.	PUNCT
dti-1304	346	4	,	,	PUNCT
dti-1304	346	5	21:675–90	21:675–90	ADJ
dti-1304	346	6	.	.	PUNCT
dti-1304	347	1	müller	müller	PROPN
dti-1304	347	2	-	-	PUNCT
dti-1304	347	3	ladner	ladner	PROPN
dti-1304	347	4	,	,	PUNCT
dti-1304	347	5	u.	u.	PROPN
dti-1304	347	6	,	,	PUNCT
dti-1304	347	7	kriegsmann	kriegsmann	PROPN
dti-1304	347	8	,	,	PUNCT
dti-1304	347	9	j.	j.	PROPN
dti-1304	347	10	,	,	PUNCT
dti-1304	347	11	franklin	franklin	PROPN
dti-1304	347	12	,	,	PUNCT
dti-1304	347	13	b.n	b.n	PROPN
dti-1304	347	14	.	.	PROPN
dti-1304	347	15	et	et	PROPN
dti-1304	347	16	al	al	PROPN
dti-1304	347	17	.	.	PROPN
dti-1304	347	18	1996	1996	NUM
dti-1304	347	19	.	.	PUNCT
dti-1304	348	1	synovial	synovial	ADJ
dti-1304	348	2	fi	fi	NOUN
dti-1304	348	3	broblasts	broblast	NOUN
dti-1304	348	4	of	of	ADP
dti-1304	348	5	patients	patient	NOUN
dti-1304	348	6	with	with	ADP
dti-1304	348	7	rheumatoid	rheumatoid	NOUN
dti-1304	348	8	arthritis	arthritis	NOUN
dti-1304	348	9	attach	attach	NOUN
dti-1304	348	10	to	to	ADP
dti-1304	348	11	and	and	CCONJ
dti-1304	348	12	invade	invade	VERB
dti-1304	348	13	normal	normal	ADJ
dti-1304	348	14	human	human	ADJ
dti-1304	348	15	cartilage	cartilage	NOUN
dti-1304	348	16	when	when	SCONJ
dti-1304	348	17	engrafted	engraft	VERB
dti-1304	348	18	into	into	ADP
dti-1304	348	19	scid	scid	PROPN
dti-1304	348	20	mice	mouse	NOUN
dti-1304	348	21	.	.	PUNCT
dti-1304	349	1	am	be	AUX
dti-1304	349	2	.	.	PUNCT
dti-1304	350	1	j.	j.	PROPN
dti-1304	350	2	pathol	pathol	PROPN
dti-1304	350	3	.	.	PROPN
dti-1304	350	4	,	,	PUNCT
dti-1304	350	5	149:1607–15	149:1607–15	X
dti-1304	350	6	.	.	PUNCT
dti-1304	351	1	müller	müller	PROPN
dti-1304	351	2	-	-	PUNCT
dti-1304	351	3	ladner	ladner	PROPN
dti-1304	351	4	,	,	PUNCT
dti-1304	351	5	u.	u.	PROPN
dti-1304	351	6	,	,	PUNCT
dti-1304	351	7	gay	gay	PROPN
dti-1304	351	8	,	,	PUNCT
dti-1304	351	9	r.e	r.e	PROPN
dti-1304	351	10	.	.	PROPN
dti-1304	351	11	and	and	CCONJ
dti-1304	351	12	gay	gay	PROPN
dti-1304	351	13	,	,	PUNCT
dti-1304	351	14	s.	s.	PROPN
dti-1304	351	15	2000	2000	NUM
dti-1304	351	16	.	.	PUNCT
dti-1304	352	1	activation	activation	NOUN
dti-1304	352	2	of	of	ADP
dti-1304	352	3	synoviocytes	synoviocyte	NOUN
dti-1304	352	4	.	.	PUNCT
dti-1304	353	1	curr	curr	PROPN
dti-1304	353	2	.	.	PUNCT
dti-1304	354	1	opin	opin	NOUN
dti-1304	354	2	.	.	PUNCT
dti-1304	355	1	rheumatol	rheumatol	NOUN
dti-1304	355	2	.	.	PUNCT
dti-1304	355	3	,	,	PUNCT
dti-1304	356	1	12:186–94	12:186–94	X
dti-1304	356	2	.	.	PUNCT
dti-1304	357	1	ohba	ohba	ADJ
dti-1304	357	2	,	,	PUNCT
dti-1304	357	3	t.	t.	PROPN
dti-1304	357	4	,	,	PUNCT
dti-1304	357	5	takase	takase	NOUN
dti-1304	357	6	,	,	PUNCT
dti-1304	357	7	y.	y.	PROPN
dti-1304	357	8	,	,	PUNCT
dti-1304	357	9	ohhara	ohhara	ADV
dti-1304	357	10	,	,	PUNCT
dti-1304	357	11	m.	m.	NOUN
dti-1304	357	12	et	et	PROPN
dti-1304	357	13	al	al	PROPN
dti-1304	357	14	.	.	PROPN
dti-1304	357	15	1996	1996	NUM
dti-1304	357	16	.	.	PUNCT
dti-1304	358	1	thrombin	thrombin	NOUN
dti-1304	358	2	in	in	ADP
dti-1304	358	3	the	the	DET
dti-1304	358	4	synovial	synovial	ADJ
dti-1304	358	5	fl	fl	PROPN
dti-1304	358	6	uid	uid	ADJ
dti-1304	358	7	of	of	ADP
dti-1304	358	8	patients	patient	NOUN
dti-1304	358	9	with	with	ADP
dti-1304	358	10	rheumatoid	rheumatoid	NOUN
dti-1304	358	11	arthritis	arthritis	NOUN
dti-1304	358	12	mediates	mediate	NOUN
dti-1304	358	13	proliferation	proliferation	NOUN
dti-1304	358	14	of	of	ADP
dti-1304	358	15	synovial	synovial	ADJ
dti-1304	358	16	fi	fi	NOUN
dti-1304	358	17	broblast	broblast	ADJ
dti-1304	358	18	-	-	PUNCT
dti-1304	358	19	like	like	ADJ
dti-1304	358	20	cells	cell	NOUN
dti-1304	358	21	by	by	ADP
dti-1304	358	22	induction	induction	NOUN
dti-1304	358	23	of	of	ADP
dti-1304	358	24	platelet	platelet	ADJ
dti-1304	358	25	-	-	PUNCT
dti-1304	358	26	derived	derive	VERB
dti-1304	358	27	growth	growth	NOUN
dti-1304	358	28	factor	factor	NOUN
dti-1304	358	29	.	.	PUNCT
dti-1304	359	1	j.	j.	PROPN
dti-1304	359	2	rheumatol	rheumatol	PROPN
dti-1304	359	3	.	.	PUNCT
dti-1304	359	4	,	,	PUNCT
dti-1304	359	5	23:1505–11	23:1505–11	NUM
dti-1304	359	6	.	.	PUNCT
dti-1304	360	1	östman	östman	NOUN
dti-1304	360	2	,	,	PUNCT
dti-1304	360	3	a.	a.	NOUN
dti-1304	360	4	and	and	CCONJ
dti-1304	360	5	heldin	heldin	PROPN
dti-1304	360	6	,	,	PUNCT
dti-1304	360	7	c	c	PROPN
dti-1304	360	8	-	-	PUNCT
dti-1304	360	9	h.	h.	PROPN
dti-1304	360	10	2001	2001	NUM
dti-1304	360	11	.	.	PUNCT
dti-1304	361	1	involvement	involvement	NOUN
dti-1304	361	2	of	of	ADP
dti-1304	361	3	platelet	platelet	NOUN
dti-1304	361	4	-	-	PUNCT
dti-1304	361	5	derived	derive	VERB
dti-1304	361	6	growth	growth	NOUN
dti-1304	361	7	factor	factor	NOUN
dti-1304	361	8	in	in	ADP
dti-1304	361	9	disease	disease	NOUN
dti-1304	361	10	:	:	PUNCT
dti-1304	361	11	development	development	NOUN
dti-1304	361	12	of	of	ADP
dti-1304	361	13	specifi	specifi	PROPN
dti-1304	361	14	c	c	PROPN
dti-1304	361	15	antagonists	antagonist	NOUN
dti-1304	361	16	.	.	PUNCT
dti-1304	362	1	adv	adv	PROPN
dti-1304	362	2	cancer	cancer	NOUN
dti-1304	362	3	res	re	NOUN
dti-1304	362	4	.	.	PUNCT
dti-1304	362	5	,	,	PUNCT
dti-1304	362	6	80:1–38	80:1–38	NUM
dti-1304	362	7	.	.	PUNCT
dti-1304	363	1	paniagua	paniagua	PROPN
dti-1304	363	2	,	,	PUNCT
dti-1304	363	3	r.t	r.t	PROPN
dti-1304	363	4	.	.	PROPN
dti-1304	363	5	,	,	PUNCT
dti-1304	363	6	sharpe	sharpe	PROPN
dti-1304	363	7	,	,	PUNCT
dti-1304	363	8	o.	o.	PROPN
dti-1304	363	9	,	,	PUNCT
dti-1304	363	10	ho	ho	PROPN
dti-1304	363	11	,	,	PUNCT
dti-1304	363	12	p.p	p.p	PROPN
dti-1304	363	13	.	.	PROPN
dti-1304	363	14	et	et	PROPN
dti-1304	363	15	al	al	PROPN
dti-1304	363	16	.	.	PROPN
dti-1304	363	17	2006	2006	NUM
dti-1304	363	18	.	.	PUNCT
dti-1304	364	1	selective	selective	ADJ
dti-1304	364	2	tyrosine	tyrosine	PROPN
dti-1304	364	3	kinase	kinase	PROPN
dti-1304	364	4	inhibition	inhibition	NOUN
dti-1304	364	5	by	by	ADP
dti-1304	364	6	imatinib	imatinib	NOUN
dti-1304	364	7	mesylate	mesylate	NOUN
dti-1304	364	8	for	for	ADP
dti-1304	364	9	the	the	DET
dti-1304	364	10	treatment	treatment	NOUN
dti-1304	364	11	of	of	ADP
dti-1304	364	12	autoimmune	autoimmune	ADJ
dti-1304	364	13	arthritis	arthritis	NOUN
dti-1304	364	14	.	.	PUNCT
dti-1304	365	1	j.	j.	PROPN
dti-1304	365	2	clin	clin	PROPN
dti-1304	365	3	.	.	PUNCT
dti-1304	366	1	invest	invest	PROPN
dti-1304	366	2	.	.	PUNCT
dti-1304	367	1	,	,	PUNCT
dti-1304	367	2	116:2633–42	116:2633–42	PROPN
dti-1304	367	3	.	.	PUNCT
dti-1304	368	1	paniagua	paniagua	PROPN
dti-1304	368	2	,	,	PUNCT
dti-1304	368	3	r.t	r.t	PROPN
dti-1304	368	4	.	.	PROPN
dti-1304	368	5	and	and	CCONJ
dti-1304	368	6	robinson	robinson	PROPN
dti-1304	368	7	,	,	PUNCT
dti-1304	368	8	w.h	w.h	PROPN
dti-1304	368	9	.	.	PROPN
dti-1304	368	10	2007	2007	NUM
dti-1304	368	11	.	.	PUNCT
dti-1304	369	1	imatinib	imatinib	NOUN
dti-1304	369	2	for	for	ADP
dti-1304	369	3	the	the	DET
dti-1304	369	4	treatment	treatment	NOUN
dti-1304	369	5	of	of	ADP
dti-1304	369	6	rheumatic	rheumatic	ADJ
dti-1304	369	7	diseases	disease	NOUN
dti-1304	369	8	.	.	PUNCT
dti-1304	370	1	nat	nat	PROPN
dti-1304	370	2	.	.	PUNCT
dti-1304	371	1	clin	clin	PROPN
dti-1304	371	2	.	.	PUNCT
dti-1304	372	1	pract	pract	PROPN
dti-1304	372	2	.	.	PUNCT
dti-1304	373	1	rheumatol	rheumatol	PROPN
dti-1304	373	2	.	.	PUNCT
dti-1304	373	3	,	,	PUNCT
dti-1304	374	1	3:190–1	3:190–1	NUM
dti-1304	374	2	.	.	PUNCT
dti-1304	374	3	pietras	pietras	PROPN
dti-1304	374	4	,	,	PUNCT
dti-1304	374	5	k.	k.	PROPN
dti-1304	374	6	,	,	PUNCT
dti-1304	374	7	sjöblom	sjöblom	PROPN
dti-1304	374	8	,	,	PUNCT
dti-1304	374	9	t.	t.	PROPN
dti-1304	374	10	,	,	PUNCT
dti-1304	374	11	rubin	rubin	PROPN
dti-1304	374	12	,	,	PUNCT
dti-1304	374	13	k.	k.	PROPN
dti-1304	374	14	et	et	PROPN
dti-1304	375	1	al	al	PROPN
dti-1304	375	2	.	.	PROPN
dti-1304	375	3	2003	2003	NUM
dti-1304	375	4	.	.	PUNCT
dti-1304	376	1	pdgf	pdgf	ADJ
dti-1304	376	2	receptors	receptor	NOUN
dti-1304	376	3	as	as	ADP
dti-1304	376	4	cancer	cancer	NOUN
dti-1304	376	5	drug	drug	NOUN
dti-1304	376	6	targets	target	NOUN
dti-1304	376	7	.	.	PUNCT
dti-1304	377	1	cancer	cancer	NOUN
dti-1304	377	2	cell	cell	NOUN
dti-1304	377	3	.	.	PUNCT
dti-1304	378	1	,	,	PUNCT
dti-1304	379	1	3:439–43	3:439–43	X
dti-1304	379	2	.	.	PUNCT
dti-1304	380	1	remmers	remmer	NOUN
dti-1304	380	2	,	,	PUNCT
dti-1304	380	3	e.f	e.f	PROPN
dti-1304	380	4	.	.	PROPN
dti-1304	380	5	,	,	PUNCT
dti-1304	380	6	sano	sano	PROPN
dti-1304	380	7	,	,	PUNCT
dti-1304	380	8	h.	h.	PROPN
dti-1304	380	9	and	and	CCONJ
dti-1304	380	10	wilder	wild	ADJ
dti-1304	380	11	,	,	PUNCT
dti-1304	380	12	r.l	r.l	PROPN
dti-1304	380	13	.	.	PROPN
dti-1304	380	14	1991	1991	NUM
dti-1304	380	15	.	.	PUNCT
dti-1304	381	1	platelet	platelet	NOUN
dti-1304	381	2	-	-	PUNCT
dti-1304	381	3	derived	derive	VERB
dti-1304	381	4	growth	growth	NOUN
dti-1304	381	5	factors	factor	NOUN
dti-1304	381	6	and	and	CCONJ
dti-1304	381	7	heparin	heparin	NOUN
dti-1304	381	8	-	-	PUNCT
dti-1304	381	9	binding	bind	VERB
dti-1304	381	10	(	(	PUNCT
dti-1304	381	11	fi	fi	NOUN
dti-1304	381	12	broblast	broblast	ADJ
dti-1304	381	13	)	)	PUNCT
dti-1304	381	14	growth	growth	NOUN
dti-1304	381	15	factors	factor	NOUN
dti-1304	381	16	in	in	ADP
dti-1304	381	17	the	the	DET
dti-1304	381	18	synovial	synovial	ADJ
dti-1304	381	19	tissue	tissue	NOUN
dti-1304	381	20	pathology	pathology	NOUN
dti-1304	381	21	of	of	ADP
dti-1304	381	22	rheumatoid	rheumatoid	PROPN
dti-1304	381	23	arthritis	arthritis	NOUN
dti-1304	381	24	.	.	PUNCT
dti-1304	382	1	semin	semin	PROPN
dti-1304	382	2	.	.	PUNCT
dti-1304	383	1	arthritis	arthritis	NOUN
dti-1304	383	2	rheum	rheum	PROPN
dti-1304	383	3	.	.	PUNCT
dti-1304	383	4	,	,	PUNCT
dti-1304	383	5	21:191–9	21:191–9	NUM
dti-1304	383	6	.	.	PUNCT
dti-1304	384	1	rice	rice	NOUN
dti-1304	384	2	,	,	PUNCT
dti-1304	384	3	a.b	a.b	PROPN
dti-1304	384	4	.	.	PROPN
dti-1304	384	5	,	,	PUNCT
dti-1304	384	6	moomaw	moomaw	NOUN
dti-1304	384	7	,	,	PUNCT
dti-1304	384	8	c.r	c.r	PROPN
dti-1304	384	9	.	.	PROPN
dti-1304	384	10	,	,	PUNCT
dti-1304	384	11	morgan	morgan	PROPN
dti-1304	384	12	,	,	PUNCT
dti-1304	384	13	d.l	d.l	PROPN
dti-1304	384	14	.	.	PROPN
dti-1304	384	15	and	and	CCONJ
dti-1304	384	16	bonner	bonner	PROPN
dti-1304	384	17	,	,	PUNCT
dti-1304	384	18	j.c	j.c	PROPN
dti-1304	384	19	.	.	PROPN
dti-1304	384	20	1999	1999	NUM
dti-1304	384	21	.	.	PUNCT
dti-1304	385	1	specifi	specifi	PROPN
dti-1304	385	2	c	c	PROPN
dti-1304	385	3	inhibitors	inhibitor	NOUN
dti-1304	385	4	of	of	ADP
dti-1304	385	5	platelet	platelet	NOUN
dti-1304	385	6	-	-	PUNCT
dti-1304	385	7	derived	derive	VERB
dti-1304	385	8	growth	growth	NOUN
dti-1304	385	9	factor	factor	NOUN
dti-1304	385	10	or	or	CCONJ
dti-1304	385	11	epidermal	epidermal	ADJ
dti-1304	385	12	growth	growth	NOUN
dti-1304	385	13	factor	factor	NOUN
dti-1304	385	14	receptor	receptor	NOUN
dti-1304	385	15	tyrosine	tyrosine	PROPN
dti-1304	385	16	kinase	kinase	PROPN
dti-1304	385	17	reduce	reduce	VERB
dti-1304	385	18	pulmonary	pulmonary	ADJ
dti-1304	385	19	fi	fi	NOUN
dti-1304	385	20	brosis	brosis	NOUN
dti-1304	385	21	in	in	ADP
dti-1304	385	22	rats	rat	NOUN
dti-1304	385	23	.	.	PUNCT
dti-1304	386	1	am	be	AUX
dti-1304	386	2	.	.	PUNCT
dti-1304	387	1	j.	j.	PROPN
dti-1304	387	2	pathol	pathol	PROPN
dti-1304	387	3	.	.	PROPN
dti-1304	387	4	,	,	PUNCT
dti-1304	387	5	155:213–21	155:213–21	NUM
dti-1304	387	6	.	.	PUNCT
dti-1304	388	1	rubin	rubin	PROPN
dti-1304	388	2	,	,	PUNCT
dti-1304	388	3	k.	k.	PROPN
dti-1304	388	4	,	,	PUNCT
dti-1304	388	5	terracio	terracio	PROPN
dti-1304	388	6	,	,	PUNCT
dti-1304	388	7	l.	l.	PROPN
dti-1304	388	8	,	,	PUNCT
dti-1304	388	9	ronnstrand	ronnstrand	PROPN
dti-1304	388	10	,	,	PUNCT
dti-1304	388	11	l.	l.	PROPN
dti-1304	388	12	et	et	PROPN
dti-1304	388	13	al	al	PROPN
dti-1304	388	14	.	.	PROPN
dti-1304	388	15	1988	1988	NUM
dti-1304	388	16	.	.	PUNCT
dti-1304	389	1	expression	expression	NOUN
dti-1304	389	2	of	of	ADP
dti-1304	389	3	plateletderived	plateletderive	VERB
dti-1304	389	4	growth	growth	NOUN
dti-1304	389	5	factor	factor	NOUN
dti-1304	389	6	receptors	receptor	NOUN
dti-1304	389	7	is	be	AUX
dti-1304	389	8	induced	induce	VERB
dti-1304	389	9	on	on	ADP
dti-1304	389	10	connective	connective	ADJ
dti-1304	389	11	tissue	tissue	NOUN
dti-1304	389	12	cells	cell	NOUN
dti-1304	389	13	during	during	ADP
dti-1304	389	14	chronic	chronic	ADJ
dti-1304	389	15	synovial	synovial	PROPN
dti-1304	389	16	infl	infl	PROPN
dti-1304	389	17	ammation	ammation	PROPN
dti-1304	389	18	.	.	PUNCT
dti-1304	390	1	scand	scand	PROPN
dti-1304	390	2	.	.	PUNCT
dti-1304	391	1	j.	j.	PROPN
dti-1304	391	2	immunol	immunol	PROPN
dti-1304	391	3	.	.	PROPN
dti-1304	391	4	,	,	PUNCT
dti-1304	391	5	27:285–94	27:285–94	PROPN
dti-1304	391	6	.	.	PUNCT
dti-1304	392	1	sadanaga	sadanaga	PROPN
dti-1304	392	2	,	,	PUNCT
dti-1304	392	3	a.	a.	PROPN
dti-1304	392	4	,	,	PUNCT
dti-1304	392	5	nakashima	nakashima	PROPN
dti-1304	392	6	,	,	PUNCT
dti-1304	392	7	h.	h.	PROPN
dti-1304	392	8	,	,	PUNCT
dti-1304	392	9	matsutani	matsutani	PROPN
dti-1304	392	10	,	,	PUNCT
dti-1304	392	11	k.	k.	PROPN
dti-1304	392	12	et	et	PROPN
dti-1304	392	13	al	al	PROPN
dti-1304	392	14	.	.	PROPN
dti-1304	392	15	2005	2005	NUM
dti-1304	392	16	.	.	PUNCT
dti-1304	393	1	amelioration	amelioration	NOUN
dti-1304	393	2	of	of	ADP
dti-1304	393	3	autoimmune	autoimmune	ADJ
dti-1304	393	4	nephritis	nephritis	NOUN
dti-1304	393	5	by	by	ADP
dti-1304	393	6	imatinib	imatinib	NOUN
dti-1304	393	7	in	in	ADP
dti-1304	393	8	mrl	mrl	PROPN
dti-1304	393	9	/	/	SYM
dti-1304	393	10	lpr	lpr	PROPN
dti-1304	393	11	mice	mouse	NOUN
dti-1304	393	12	.	.	PUNCT
dti-1304	394	1	arthritis	arthritis	NOUN
dti-1304	394	2	rheum	rheum	NOUN
dti-1304	394	3	.	.	PUNCT
dti-1304	394	4	,	,	PUNCT
dti-1304	395	1	52:3987–96	52:3987–96	NUM
dti-1304	395	2	.	.	PUNCT
dti-1304	396	1	sandler	sandler	PROPN
dti-1304	396	2	,	,	PUNCT
dti-1304	396	3	c.	c.	PROPN
dti-1304	396	4	,	,	PUNCT
dti-1304	396	5	joutsiniemi	joutsiniemi	PROPN
dti-1304	396	6	,	,	PUNCT
dti-1304	396	7	s.	s.	PROPN
dti-1304	396	8	,	,	PUNCT
dti-1304	396	9	lindstedt	lindstedt	PROPN
dti-1304	396	10	,	,	PUNCT
dti-1304	396	11	k.a	k.a	PROPN
dti-1304	396	12	.	.	PROPN
dti-1304	396	13	et	et	PROPN
dti-1304	396	14	al	al	PROPN
dti-1304	396	15	.	.	PROPN
dti-1304	396	16	2006	2006	NUM
dti-1304	396	17	.	.	PUNCT
dti-1304	397	1	imatinib	imatinib	NOUN
dti-1304	397	2	mesylate	mesylate	NOUN
dti-1304	397	3	inhibits	inhibit	VERB
dti-1304	397	4	platelet	platelet	NOUN
dti-1304	397	5	derived	derive	VERB
dti-1304	397	6	growth	growth	NOUN
dti-1304	397	7	factor	factor	NOUN
dti-1304	397	8	stimulated	stimulate	VERB
dti-1304	397	9	proliferation	proliferation	NOUN
dti-1304	397	10	of	of	ADP
dti-1304	397	11	rheumatoid	rheumatoid	NOUN
dti-1304	397	12	synovial	synovial	ADJ
dti-1304	397	13	fi	fi	NOUN
dti-1304	397	14	broblasts	broblast	NOUN
dti-1304	397	15	.	.	PUNCT
dti-1304	398	1	biochem	biochem	PROPN
dti-1304	398	2	.	.	PUNCT
dti-1304	399	1	biophys	biophy	NOUN
dti-1304	399	2	.	.	PUNCT
dti-1304	400	1	res	re	NOUN
dti-1304	400	2	.	.	PUNCT
dti-1304	401	1	commun	commun	PROPN
dti-1304	401	2	.	.	PROPN
dti-1304	401	3	,	,	PUNCT
dti-1304	401	4	347:31–5	347:31–5	X
dti-1304	401	5	.	.	X
dti-1304	401	6	sano	sano	PROPN
dti-1304	401	7	,	,	PUNCT
dti-1304	401	8	h.	h.	PROPN
dti-1304	401	9	,	,	PUNCT
dti-1304	401	10	engleka	engleka	PROPN
dti-1304	401	11	,	,	PUNCT
dti-1304	401	12	k.	k.	PROPN
dti-1304	401	13	,	,	PUNCT
dti-1304	401	14	mathern	mathern	PROPN
dti-1304	401	15	,	,	PUNCT
dti-1304	401	16	p.	p.	NOUN
dti-1304	401	17	et	et	NOUN
dti-1304	402	1	al	al	PROPN
dti-1304	402	2	.	.	PROPN
dti-1304	402	3	1993	1993	NUM
dti-1304	402	4	.	.	PUNCT
dti-1304	403	1	coexpression	coexpression	NOUN
dti-1304	403	2	of	of	ADP
dti-1304	403	3	phosphotyrosine	phosphotyrosine	NOUN
dti-1304	403	4	-	-	PUNCT
dti-1304	403	5	containing	contain	VERB
dti-1304	403	6	proteins	protein	NOUN
dti-1304	403	7	,	,	PUNCT
dti-1304	403	8	platelet	platelet	NOUN
dti-1304	403	9	-	-	PUNCT
dti-1304	403	10	derived	derive	VERB
dti-1304	403	11	growth	growth	NOUN
dti-1304	403	12	factor	factor	NOUN
dti-1304	403	13	-	-	PUNCT
dti-1304	403	14	b	b	NOUN
dti-1304	403	15	,	,	PUNCT
dti-1304	403	16	and	and	CCONJ
dti-1304	403	17	fi	fi	NOUN
dti-1304	403	18	broblast	broblast	ADJ
dti-1304	403	19	growth	growth	NOUN
dti-1304	403	20	factor-1	factor-1	NUM
dti-1304	403	21	in	in	ADP
dti-1304	403	22	situ	situ	NOUN
dti-1304	403	23	in	in	ADP
dti-1304	403	24	synovial	synovial	ADJ
dti-1304	403	25	tissues	tissue	NOUN
dti-1304	403	26	of	of	ADP
dti-1304	403	27	patients	patient	NOUN
dti-1304	403	28	with	with	ADP
dti-1304	403	29	rheumatoid	rheumatoid	NOUN
dti-1304	403	30	arthritis	arthritis	NOUN
dti-1304	403	31	and	and	CCONJ
dti-1304	403	32	lewis	lewis	PROPN
dti-1304	403	33	rats	rat	NOUN
dti-1304	403	34	with	with	ADP
dti-1304	403	35	adjuvant	adjuvant	ADJ
dti-1304	403	36	or	or	CCONJ
dti-1304	403	37	streptococcal	streptococcal	ADJ
dti-1304	403	38	cell	cell	NOUN
dti-1304	403	39	wall	wall	NOUN
dti-1304	403	40	arthritis	arthritis	PROPN
dti-1304	403	41	.	.	PUNCT
dti-1304	404	1	j.	j.	PROPN
dti-1304	404	2	clin	clin	PROPN
dti-1304	404	3	.	.	PUNCT
dti-1304	405	1	invest	invest	PROPN
dti-1304	405	2	.	.	PUNCT
dti-1304	405	3	,	,	PUNCT
dti-1304	405	4	91:553–65	91:553–65	PROPN
dti-1304	405	5	.	.	PUNCT
dti-1304	406	1	schermuly	schermuly	PROPN
dti-1304	406	2	,	,	PUNCT
dti-1304	406	3	r.t	r.t	PROPN
dti-1304	406	4	.	.	PROPN
dti-1304	406	5	,	,	PUNCT
dti-1304	406	6	dony	dony	PROPN
dti-1304	406	7	,	,	PUNCT
dti-1304	406	8	e.	e.	PROPN
dti-1304	406	9	,	,	PUNCT
dti-1304	406	10	ghofrani	ghofrani	PROPN
dti-1304	406	11	,	,	PUNCT
dti-1304	406	12	h.a	h.a	PROPN
dti-1304	406	13	.	.	PROPN
dti-1304	406	14	et	et	PROPN
dti-1304	406	15	al	al	PROPN
dti-1304	406	16	.	.	PROPN
dti-1304	406	17	2005	2005	NUM
dti-1304	406	18	.	.	PUNCT
dti-1304	407	1	reversal	reversal	NOUN
dti-1304	407	2	of	of	ADP
dti-1304	407	3	experimental	experimental	ADJ
dti-1304	407	4	pulmonary	pulmonary	ADJ
dti-1304	407	5	hypertension	hypertension	NOUN
dti-1304	407	6	by	by	ADP
dti-1304	407	7	pdgf	pdgf	ADJ
dti-1304	407	8	inhibition	inhibition	NOUN
dti-1304	407	9	.	.	PUNCT
dti-1304	408	1	j.	j.	PROPN
dti-1304	408	2	clin	clin	PROPN
dti-1304	408	3	.	.	PUNCT
dti-1304	409	1	invest	invest	PROPN
dti-1304	409	2	.	.	PUNCT
dti-1304	409	3	,	,	PUNCT
dti-1304	410	1	115:2811–21	115:2811–21	NUM
dti-1304	410	2	.	.	PUNCT
dti-1304	410	3	takeuchi	takeuchi	PROPN
dti-1304	410	4	,	,	PUNCT
dti-1304	410	5	t.	t.	PROPN
dti-1304	410	6	,	,	PUNCT
dti-1304	410	7	amano	amano	PROPN
dti-1304	410	8	,	,	PUNCT
dti-1304	410	9	k.	k.	PROPN
dti-1304	410	10	,	,	PUNCT
dti-1304	410	11	kameda	kameda	PROPN
dti-1304	410	12	,	,	PUNCT
dti-1304	410	13	h.	h.	PROPN
dti-1304	410	14	and	and	CCONJ
dti-1304	410	15	abe	abe	PROPN
dti-1304	410	16	,	,	PUNCT
dti-1304	410	17	t.	t.	PROPN
dti-1304	410	18	2005	2005	NUM
dti-1304	410	19	.	.	PUNCT
dti-1304	411	1	anti	anti	ADJ
dti-1304	411	2	-	-	ADJ
dti-1304	411	3	tnf	tnf	ADJ
dti-1304	411	4	biological	biological	ADJ
dti-1304	411	5	agents	agent	NOUN
dti-1304	411	6	in	in	ADP
dti-1304	411	7	rheumatoid	rheumatoid	NOUN
dti-1304	411	8	arthritis	arthritis	NOUN
dti-1304	411	9	and	and	CCONJ
dti-1304	411	10	other	other	ADJ
dti-1304	411	11	infl	infl	PROPN
dti-1304	411	12	ammatory	ammatory	NOUN
dti-1304	411	13	diseases	disease	NOUN
dti-1304	411	14	.	.	PUNCT
dti-1304	412	1	allergology	allergology	NOUN
dti-1304	412	2	international	international	PROPN
dti-1304	412	3	,	,	PUNCT
dti-1304	412	4	54:191–202	54:191–202	PROPN
dti-1304	412	5	.	.	PUNCT
dti-1304	413	1	thornton	thornton	PROPN
dti-1304	413	2	,	,	PUNCT
dti-1304	413	3	s.c	s.c	PROPN
dti-1304	413	4	.	.	PROPN
dti-1304	413	5	,	,	PUNCT
dti-1304	413	6	por	por	NOUN
dti-1304	413	7	,	,	PUNCT
dti-1304	413	8	s.b	s.b	PROPN
dti-1304	413	9	.	.	PROPN
dti-1304	413	10	,	,	PUNCT
dti-1304	413	11	penny	penny	PROPN
dti-1304	413	12	,	,	PUNCT
dti-1304	413	13	r.	r.	PROPN
dti-1304	413	14	,	,	PUNCT
dti-1304	413	15	richter	richter	PROPN
dti-1304	413	16	,	,	PUNCT
dti-1304	413	17	m.	m.	NOUN
dti-1304	413	18	,	,	PUNCT
dti-1304	413	19	shelley	shelley	PROPN
dti-1304	413	20	,	,	PUNCT
dti-1304	413	21	l.	l.	PROPN
dti-1304	413	22	and	and	CCONJ
dti-1304	413	23	breit	breit	PROPN
dti-1304	413	24	,	,	PUNCT
dti-1304	413	25	s.n	s.n	PROPN
dti-1304	413	26	.	.	PROPN
dti-1304	413	27	1991	1991	NUM
dti-1304	413	28	.	.	PUNCT
dti-1304	414	1	identifi	identifi	PROPN
dti-1304	414	2	cation	cation	NOUN
dti-1304	414	3	of	of	ADP
dti-1304	414	4	the	the	DET
dti-1304	414	5	major	major	ADJ
dti-1304	414	6	fi	fi	NOUN
dti-1304	414	7	broblast	broblast	ADJ
dti-1304	414	8	growth	growth	NOUN
dti-1304	414	9	factors	factor	NOUN
dti-1304	414	10	released	release	VERB
dti-1304	414	11	spontaneously	spontaneously	ADV
dti-1304	414	12	in	in	ADP
dti-1304	414	13	infl	infl	PROPN
dti-1304	414	14	ammatory	ammatory	NOUN
dti-1304	414	15	arthritis	arthritis	NOUN
dti-1304	414	16	as	as	ADP
dti-1304	414	17	platelet	platelet	NOUN
dti-1304	414	18	-	-	PUNCT
dti-1304	414	19	derived	derive	VERB
dti-1304	414	20	growth	growth	NOUN
dti-1304	414	21	factor	factor	NOUN
dti-1304	414	22	and	and	CCONJ
dti-1304	414	23	tumor	tumor	NOUN
dti-1304	414	24	necrosis	necrosis	NOUN
dti-1304	414	25	factor	factor	NOUN
dti-1304	414	26	-	-	PUNCT
dti-1304	414	27	alpha	alpha	NOUN
dti-1304	414	28	.	.	PUNCT
dti-1304	415	1	clin	clin	PROPN
dti-1304	415	2	.	.	PUNCT
dti-1304	416	1	exp	exp	PROPN
dti-1304	416	2	.	.	PUNCT
dti-1304	416	3	imunol	imunol	PROPN
dti-1304	416	4	.	.	PROPN
dti-1304	416	5	,	,	PUNCT
dti-1304	416	6	86:79–86	86:79–86	NUM
dti-1304	416	7	.	.	PUNCT
dti-1304	417	1	vittal	vittal	PROPN
dti-1304	417	2	,	,	PUNCT
dti-1304	417	3	r.	r.	PROPN
dti-1304	417	4	,	,	PUNCT
dti-1304	417	5	zhang	zhang	PROPN
dti-1304	417	6	,	,	PUNCT
dti-1304	417	7	h.	h.	PROPN
dti-1304	417	8	,	,	PUNCT
dti-1304	417	9	han	han	PROPN
dti-1304	417	10	,	,	PUNCT
dti-1304	417	11	m.k	m.k	PROPN
dti-1304	417	12	.	.	PROPN
dti-1304	417	13	,	,	PUNCT
dti-1304	417	14	moore	moore	PROPN
dti-1304	417	15	,	,	PUNCT
dti-1304	417	16	b.b	b.b	PROPN
dti-1304	417	17	.	.	PROPN
dti-1304	417	18	,	,	PUNCT
dti-1304	417	19	horowitz	horowitz	PROPN
dti-1304	417	20	,	,	PUNCT
dti-1304	417	21	j.c	j.c	PROPN
dti-1304	417	22	.	.	PROPN
dti-1304	417	23	and	and	CCONJ
dti-1304	417	24	thannickal	thannickal	NOUN
dti-1304	417	25	,	,	PUNCT
dti-1304	417	26	v.j	v.j	PROPN
dti-1304	417	27	.	.	PROPN
dti-1304	417	28	2007	2007	NUM
dti-1304	417	29	.	.	PUNCT
dti-1304	418	1	effects	effect	NOUN
dti-1304	418	2	of	of	ADP
dti-1304	418	3	the	the	DET
dti-1304	418	4	protein	protein	NOUN
dti-1304	418	5	kinase	kinase	NOUN
dti-1304	418	6	inhibitor	inhibitor	NOUN
dti-1304	418	7	,	,	PUNCT
dti-1304	418	8	imatinib	imatinib	NOUN
dti-1304	418	9	mesylate	mesylate	VERB
dti-1304	418	10	,	,	PUNCT
dti-1304	418	11	on	on	ADP
dti-1304	418	12	epithelial	epithelial	ADJ
dti-1304	418	13	/	/	SYM
dti-1304	418	14	mesenchymal	mesenchymal	NOUN
dti-1304	418	15	phenotypes	phenotype	NOUN
dti-1304	418	16	:	:	PUNCT
dti-1304	418	17	implications	implication	NOUN
dti-1304	418	18	for	for	ADP
dti-1304	418	19	treatment	treatment	NOUN
dti-1304	418	20	of	of	ADP
dti-1304	418	21	fi	fi	NOUN
dti-1304	418	22	brotic	brotic	ADJ
dti-1304	418	23	diseases	disease	NOUN
dti-1304	418	24	.	.	PUNCT
dti-1304	419	1	j.	j.	PROPN
dti-1304	419	2	pharmacol	pharmacol	PROPN
dti-1304	419	3	.	.	PUNCT
dti-1304	420	1	exp	exp	PROPN
dti-1304	420	2	.	.	PUNCT
dti-1304	421	1	ther	ther	PROPN
dti-1304	421	2	.	.	PUNCT
dti-1304	421	3	,	,	PUNCT
dti-1304	421	4	321:35–44	321:35–44	NUM
dti-1304	421	5	.	.	PUNCT
dti-1304	421	6	watanabe	watanabe	PROPN
dti-1304	421	7	,	,	PUNCT
dti-1304	421	8	n.	n.	PROPN
dti-1304	421	9	,	,	PUNCT
dti-1304	421	10	ando	ando	PROPN
dti-1304	421	11	,	,	PUNCT
dti-1304	421	12	k.	k.	PROPN
dti-1304	421	13	,	,	PUNCT
dti-1304	421	14	yoshida	yoshida	PROPN
dti-1304	421	15	,	,	PUNCT
dti-1304	421	16	s.	s.	PROPN
dti-1304	421	17	et	et	PROPN
dti-1304	421	18	al	al	PROPN
dti-1304	421	19	.	.	PROPN
dti-1304	421	20	2002	2002	NUM
dti-1304	421	21	.	.	PUNCT
dti-1304	422	1	gene	gene	NOUN
dti-1304	422	2	expression	expression	NOUN
dti-1304	422	3	profi	profi	PROPN
dti-1304	422	4	le	le	PROPN
dti-1304	422	5	analysis	analysis	NOUN
dti-1304	422	6	of	of	ADP
dti-1304	422	7	rheumatoid	rheumatoid	ADJ
dti-1304	422	8	synovial	synovial	ADJ
dti-1304	422	9	fi	fi	NOUN
dti-1304	422	10	broblast	broblast	ADJ
dti-1304	422	11	cultures	culture	NOUN
dti-1304	422	12	revealing	reveal	VERB
dti-1304	422	13	the	the	DET
dti-1304	422	14	overexpression	overexpression	NOUN
dti-1304	422	15	of	of	ADP
dti-1304	422	16	genes	gene	NOUN
dti-1304	422	17	responsible	responsible	ADJ
dti-1304	422	18	for	for	ADP
dti-1304	422	19	tumor	tumor	NOUN
dti-1304	422	20	-	-	PUNCT
dti-1304	422	21	like	like	ADJ
dti-1304	422	22	growth	growth	NOUN
dti-1304	422	23	of	of	ADP
dti-1304	422	24	rheumatoid	rheumatoid	NOUN
dti-1304	422	25	synovium	synovium	NOUN
dti-1304	422	26	.	.	PUNCT
dti-1304	423	1	biochem	biochem	PROPN
dti-1304	423	2	.	.	PUNCT
dti-1304	424	1	biophys	biophy	NOUN
dti-1304	424	2	.	.	PUNCT
dti-1304	425	1	res	re	NOUN
dti-1304	425	2	.	.	PUNCT
dti-1304	426	1	commun	commun	PROPN
dti-1304	426	2	.	.	PROPN
dti-1304	426	3	,	,	PUNCT
dti-1304	427	1	294:1121–9	294:1121–9	X
dti-1304	427	2	.	.	PUNCT
dti-1304	428	1	white	white	PROPN
dti-1304	428	2	,	,	PUNCT
dti-1304	428	3	b.	b.	PROPN
dti-1304	428	4	,	,	PUNCT
dti-1304	428	5	moore	moore	PROPN
dti-1304	428	6	,	,	PUNCT
dti-1304	428	7	w.c	w.c	PROPN
dti-1304	428	8	.	.	PROPN
dti-1304	428	9	,	,	PUNCT
dti-1304	428	10	wigly	wigly	ADV
dti-1304	428	11	,	,	PUNCT
dti-1304	429	1	f.m	f.m	PROPN
dti-1304	429	2	.	.	PROPN
dti-1304	429	3	,	,	PUNCT
dti-1304	429	4	xiao	xiao	PROPN
dti-1304	429	5	,	,	PUNCT
dti-1304	429	6	h.q	h.q	PROPN
dti-1304	429	7	.	.	PROPN
dti-1304	429	8	and	and	CCONJ
dti-1304	429	9	wise	wise	ADJ
dti-1304	429	10	,	,	PUNCT
dti-1304	429	11	r.a	r.a	PROPN
dti-1304	429	12	.	.	PROPN
dti-1304	429	13	2000	2000	NUM
dti-1304	429	14	.	.	PUNCT
dti-1304	430	1	cyclophosphamide	cyclophosphamide	PROPN
dti-1304	430	2	is	be	AUX
dti-1304	430	3	associated	associate	VERB
dti-1304	430	4	with	with	ADP
dti-1304	430	5	pulmonary	pulmonary	ADJ
dti-1304	430	6	function	function	NOUN
dti-1304	430	7	and	and	CCONJ
dti-1304	430	8	survival	survival	NOUN
dti-1304	430	9	benefi	benefi	PROPN
dti-1304	430	10	t	t	PROPN
dti-1304	430	11	in	in	ADP
dti-1304	430	12	patients	patient	NOUN
dti-1304	430	13	with	with	ADP
dti-1304	430	14	scleroderma	scleroderma	NOUN
dti-1304	430	15	and	and	CCONJ
dti-1304	430	16	alveolitis	alveolitis	PROPN
dti-1304	430	17	.	.	PUNCT
dti-1304	431	1	ann	ann	PROPN
dti-1304	431	2	.	.	PUNCT
dti-1304	431	3	intern	intern	PROPN
dti-1304	431	4	.	.	PUNCT
dti-1304	432	1	med	med	PROPN
dti-1304	432	2	.	.	PROPN
dti-1304	432	3	,	,	PUNCT
dti-1304	432	4	132:947–54	132:947–54	NUM
dti-1304	432	5	.	.	PUNCT
dti-1304	433	1	wollheim	wollheim	PROPN
dti-1304	433	2	,	,	PUNCT
dti-1304	433	3	f.a	f.a	PROPN
dti-1304	433	4	.	.	PROPN
dti-1304	433	5	2007	2007	NUM
dti-1304	433	6	.	.	PUNCT
dti-1304	434	1	treatment	treatment	NOUN
dti-1304	434	2	of	of	ADP
dti-1304	434	3	pulmonary	pulmonary	ADJ
dti-1304	434	4	fi	fi	NOUN
dti-1304	434	5	brosis	brosis	NOUN
dti-1304	434	6	in	in	ADP
dti-1304	434	7	systemic	systemic	ADJ
dti-1304	434	8	sclerosis	sclerosis	NOUN
dti-1304	434	9	:	:	PUNCT
dti-1304	434	10	light	light	NOUN
dti-1304	434	11	at	at	ADP
dti-1304	434	12	the	the	DET
dti-1304	434	13	end	end	NOUN
dti-1304	434	14	of	of	ADP
dti-1304	434	15	the	the	DET
dti-1304	434	16	tunnel	tunnel	NOUN
dti-1304	434	17	?	?	PUNCT
dti-1304	435	1	arthritis	arthritis	NOUN
dti-1304	435	2	rheum	rheum	NOUN
dti-1304	435	3	.	.	PUNCT
dti-1304	435	4	,	,	PUNCT
dti-1304	436	1	56:9–12	56:9–12	NUM
dti-1304	436	2	.	.	PUNCT
dti-1304	437	1	yamanishi	yamanishi	PROPN
dti-1304	437	2	,	,	PUNCT
dti-1304	437	3	y.	y.	PROPN
dti-1304	437	4	and	and	CCONJ
dti-1304	437	5	firestein	firestein	PROPN
dti-1304	437	6	,	,	PUNCT
dti-1304	437	7	g.s	g.s	PROPN
dti-1304	437	8	.	.	PROPN
dti-1304	437	9	2001	2001	NUM
dti-1304	437	10	.	.	PUNCT
dti-1304	438	1	pathogenesis	pathogenesis	NOUN
dti-1304	438	2	of	of	ADP
dti-1304	438	3	rheumatoid	rheumatoid	NOUN
dti-1304	438	4	arthritis	arthritis	NOUN
dti-1304	438	5	:	:	PUNCT
dti-1304	438	6	the	the	DET
dti-1304	438	7	role	role	NOUN
dti-1304	438	8	of	of	ADP
dti-1304	438	9	synoviocytes	synoviocyte	NOUN
dti-1304	438	10	.	.	PUNCT
dti-1304	439	1	rheum	rheum	PROPN
dti-1304	439	2	dis	dis	PROPN
dti-1304	439	3	.	.	PUNCT
dti-1304	440	1	clin	clin	PROPN
dti-1304	440	2	.	.	PUNCT
dti-1304	441	1	north	north	PROPN
dti-1304	441	2	am	am	PROPN
dti-1304	441	3	.	.	PUNCT
dti-1304	441	4	,	,	PUNCT
dti-1304	441	5	27:355–71	27:355–71	PROPN
dti-1304	441	6	.	.	PUNCT
dti-1304	442	1	yoshida	yoshida	PROPN
dti-1304	442	2	,	,	PUNCT
dti-1304	442	3	m.	m.	NOUN
dti-1304	442	4	,	,	PUNCT
dti-1304	442	5	sakuma	sakuma	NOUN
dti-1304	442	6	-	-	PUNCT
dti-1304	442	7	mochizuki	mochizuki	PROPN
dti-1304	442	8	,	,	PUNCT
dti-1304	442	9	j.	j.	PROPN
dti-1304	442	10	,	,	PUNCT
dti-1304	442	11	abe	abe	PROPN
dti-1304	442	12	,	,	PUNCT
dti-1304	442	13	k.	k.	PROPN
dti-1304	442	14	et	et	PROPN
dti-1304	442	15	al	al	PROPN
dti-1304	442	16	.	.	PROPN
dti-1304	442	17	1999	1999	NUM
dti-1304	442	18	.	.	PUNCT
dti-1304	443	1	in	in	ADP
dti-1304	443	2	vivo	vivo	ADJ
dti-1304	443	3	gene	gene	NOUN
dti-1304	443	4	transfer	transfer	NOUN
dti-1304	443	5	of	of	ADP
dti-1304	443	6	an	an	DET
dti-1304	443	7	extracellular	extracellular	ADJ
dti-1304	443	8	domain	domain	NOUN
dti-1304	443	9	of	of	ADP
dti-1304	443	10	platelet	platelet	NOUN
dti-1304	443	11	-	-	PUNCT
dti-1304	443	12	derived	derive	VERB
dti-1304	443	13	growth	growth	NOUN
dti-1304	443	14	factor	factor	NOUN
dti-1304	443	15	β	β	NOUN
dti-1304	443	16	receptor	receptor	NOUN
dti-1304	443	17	by	by	ADP
dti-1304	443	18	the	the	DET
dti-1304	443	19	hvj	hvj	VERB
dti-1304	443	20	-	-	PUNCT
dti-1304	443	21	liposome	liposome	NOUN
dti-1304	443	22	method	method	NOUN
dti-1304	443	23	ameliorates	ameliorate	VERB
dti-1304	443	24	bleomycininduced	bleomycininduce	VERB
dti-1304	443	25	pulmonary	pulmonary	ADJ
dti-1304	443	26	fi	fi	NOUN
dti-1304	443	27	brosis	brosis	NOUN
dti-1304	443	28	.	.	PUNCT
dti-1304	444	1	biochem	biochem	PROPN
dti-1304	444	2	.	.	PUNCT
dti-1304	445	1	biophys	biophy	NOUN
dti-1304	445	2	.	.	PUNCT
dti-1304	446	1	res	re	NOUN
dti-1304	446	2	.	.	PUNCT
dti-1304	447	1	commun	commun	PROPN
dti-1304	447	2	.	.	PROPN
dti-1304	448	1	,	,	PUNCT
dti-1304	449	1	265:503–8	265:503–8	NUM
dti-1304	449	2	.	.	PUNCT
dti-1304	450	1	zoja	zoja	PROPN
dti-1304	450	2	,	,	PUNCT
dti-1304	450	3	c.	c.	PROPN
dti-1304	450	4	,	,	PUNCT
dti-1304	450	5	corna	corna	PROPN
dti-1304	450	6	,	,	PUNCT
dti-1304	450	7	d.	d.	PROPN
dti-1304	450	8	,	,	PUNCT
dti-1304	450	9	rottoli	rottoli	PROPN
dti-1304	450	10	,	,	PUNCT
dti-1304	450	11	d.	d.	PROPN
dti-1304	450	12	,	,	PUNCT
dti-1304	450	13	zanchi	zanchi	PROPN
dti-1304	450	14	,	,	PUNCT
dti-1304	450	15	c.	c.	NOUN
dti-1304	450	16	,	,	PUNCT
dti-1304	450	17	abbate	abbate	ADJ
dti-1304	450	18	,	,	PUNCT
dti-1304	450	19	m.	m.	NOUN
dti-1304	450	20	and	and	CCONJ
dti-1304	450	21	remuzzi	remuzzi	VERB
dti-1304	450	22	,	,	PUNCT
dti-1304	450	23	g.	g.	PROPN
dti-1304	450	24	2006	2006	NUM
dti-1304	450	25	.	.	PUNCT
dti-1304	451	1	imatinib	imatinib	NOUN
dti-1304	451	2	ameliorates	ameliorate	VERB
dti-1304	451	3	renal	renal	ADJ
dti-1304	451	4	disease	disease	NOUN
dti-1304	451	5	and	and	CCONJ
dti-1304	451	6	survival	survival	NOUN
dti-1304	451	7	in	in	ADP
dti-1304	451	8	murine	murine	ADJ
dti-1304	451	9	lupus	lupus	ADJ
dti-1304	451	10	autoimmune	autoimmune	ADJ
dti-1304	451	11	disease	disease	NOUN
dti-1304	451	12	.	.	PUNCT
dti-1304	452	1	kidney	kidney	NOUN
dti-1304	452	2	int	int	PROPN
dti-1304	452	3	.	.	PUNCT
dti-1304	452	4	,	,	PUNCT
dti-1304	452	5	70:97–103	70:97–103	NUM
dti-1304	452	6	.	.	PUNCT
dti-1304	453	1	<	<	X
dti-1304	453	2	<	<	X
dti-1304	453	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1304	453	4	false	false	ADJ
dti-1304	453	5	/allowtransparency	/allowtransparency	NOUN
dti-1304	453	6	false	false	ADJ
dti-1304	453	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1304	453	8	true	true	ADJ
dti-1304	453	9	/autorotatepages	/autorotatepage	NOUN
dti-1304	453	10	/none	/none	PUNCT
dti-1304	453	11	/binding	/binding	PUNCT
dti-1304	453	12	/left	/left	ADJ
dti-1304	454	1	/calgrayprofile	/calgrayprofile	VERB
dti-1304	454	2	(	(	PUNCT
dti-1304	454	3	dot	dot	NOUN
dti-1304	454	4	gain	gain	NOUN
dti-1304	454	5	20	20	NUM
dti-1304	454	6	%	%	NOUN
dti-1304	454	7	)	)	PUNCT
dti-1304	454	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1304	455	1	(	(	PUNCT
dti-1304	455	2	srgb	srgb	PROPN
dti-1304	455	3	iec61966	iec61966	NOUN
dti-1304	455	4	-	-	PUNCT
dti-1304	455	5	2.1	2.1	NUM
dti-1304	455	6	)	)	PUNCT
dti-1304	455	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1304	456	1	(	(	PUNCT
dti-1304	456	2	u.s	u.s	PROPN
dti-1304	456	3	.	.	PROPN
dti-1304	456	4	web	web	NOUN
dti-1304	456	5	coated	coat	VERB
dti-1304	456	6	\050swop\051	\050swop\051	ADJ
dti-1304	456	7	v2	v2	NOUN
dti-1304	456	8	)	)	PUNCT
dti-1304	456	9	/srgbprofile	/srgbprofile	PUNCT
dti-1304	456	10	(	(	PUNCT
dti-1304	456	11	srgb	srgb	PROPN
dti-1304	456	12	iec61966	iec61966	NOUN
dti-1304	456	13	-	-	PUNCT
dti-1304	456	14	2.1	2.1	NUM
dti-1304	456	15	)	)	PUNCT
dti-1304	456	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1304	457	1	/error	/error	INTJ
dti-1304	457	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1304	458	1	1.4	1.4	NUM
dti-1304	458	2	/compressobjects	/compressobject	NOUN
dti-1304	458	3	/tags	/tag	VERB
dti-1304	458	4	/compresspages	/compresspage	NOUN
dti-1304	458	5	true	true	ADJ
dti-1304	458	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1304	458	7	true	true	ADJ
dti-1304	458	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1304	458	9	true	true	ADJ
dti-1304	458	10	/createjdffile	/createjdffile	ADJ
dti-1304	458	11	false	false	ADJ
dti-1304	458	12	/createjobticket	/createjobticket	NOUN
dti-1304	458	13	false	false	ADJ
dti-1304	458	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1304	458	15	/default	/default	PUNCT
dti-1304	458	16	/detectblends	/detectblend	NOUN
dti-1304	458	17	true	true	ADJ
dti-1304	458	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1304	458	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1304	458	20	/dothumbnails	/dothumbnail	VERB
dti-1304	458	21	false	false	ADJ
dti-1304	458	22	/embedallfonts	/embedallfont	NOUN
dti-1304	458	23	true	true	ADJ
dti-1304	458	24	/embedjoboptions	/embedjoboption	NOUN
dti-1304	458	25	true	true	ADJ
dti-1304	458	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1304	458	27	0	0	NUM
dti-1304	458	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1304	458	29	false	false	ADJ
dti-1304	458	30	/endpage	/endpage	NOUN
dti-1304	458	31	-1	-1	NOUN
dti-1304	458	32	/imagememory	/imagememory	NUM
dti-1304	459	1	1048576	1048576	NUM
dti-1304	459	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1304	459	3	false	false	ADJ
dti-1304	459	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1304	459	5	100	100	NUM
dti-1304	459	6	/optimize	/optimize	NOUN
dti-1304	459	7	true	true	ADJ
dti-1304	459	8	/opm	/opm	NOUN
dti-1304	459	9	1	1	NUM
dti-1304	459	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1304	459	11	true	true	ADJ
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dti-1304	459	15	true	true	ADJ
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dti-1304	459	25	1	1	NUM
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dti-1304	486	4	/ptb	/ptb	PROPN
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dti-1304	488	2	>	>	X
dti-1304	488	3	/dan	/dan	PUNCT
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dti-1304	489	3	>	>	X
dti-1304	489	4	/nld	/nld	PUNCT
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dti-1304	490	3	>	>	X
dti-1304	490	4	/esp	/esp	PUNCT
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dti-1304	491	3	>	>	X
dti-1304	491	4	/suo	/suo	PUNCT
dti-1304	492	1	<	<	X
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dti-1304	492	3	>	>	X
dti-1304	492	4	/ita	/ita	PUNCT
dti-1304	493	1	<	<	X
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dti-1304	493	3	>	>	X
dti-1304	493	4	/nor	/nor	X
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dti-1304	493	7	>	>	X
dti-1304	493	8	/sve	/sve	NOUN
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dti-1304	494	3	>	>	X
dti-1304	494	4	/enu	/enu	PROPN
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dti-1304	494	7	>	>	X
dti-1304	494	8	>	>	X
dti-1304	494	9	>	>	X
dti-1304	494	10	>	>	X
dti-1304	494	11	>	>	X
dti-1304	494	12	setdistillerparams	setdistillerparam	NOUN
dti-1304	495	1	<	<	X
dti-1304	495	2	<	<	X
dti-1304	495	3	/hwresolution	/hwresolution	NOUN
dti-1304	496	1	[	[	X
dti-1304	496	2	2400	2400	NUM
dti-1304	496	3	2400	2400	NUM
dti-1304	496	4	]	]	PUNCT
dti-1304	496	5	/pagesize	/pagesize	X
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