id	sid	tid	token	lemma	pos
dti-1305	1	1	khan	khan	PROPN
dti-1305	1	2	et	et	PROPN
dti-1305	1	3	al.indd	al.indd	PROPN
dti-1305	1	4	129	129	NUM
dti-1305	1	5	review	review	NOUN
dti-1305	1	6	correspondence	correspondence	NOUN
dti-1305	1	7	:	:	PUNCT
dti-1305	1	8	m.	m.	PROPN
dti-1305	1	9	omar	omar	PROPN
dti-1305	1	10	f.	f.	PROPN
dti-1305	1	11	khan	khan	PROPN
dti-1305	1	12	,	,	PUNCT
dti-1305	1	13	tel	tel	PROPN
dti-1305	1	14	:	:	PUNCT
dti-1305	1	15	(	(	PUNCT
dti-1305	1	16	1)580	1)580	NUM
dti-1305	1	17	-	-	PUNCT
dti-1305	1	18	774	774	NUM
dti-1305	1	19	-	-	SYM
dti-1305	1	20	3064	3064	NUM
dti-1305	1	21	;	;	PUNCT
dti-1305	1	22	fax	fax	NOUN
dti-1305	1	23	:	:	PUNCT
dti-1305	1	24	(	(	PUNCT
dti-1305	1	25	1)580	1)580	NUM
dti-1305	1	26	-	-	PUNCT
dti-1305	1	27	774	774	NUM
dti-1305	1	28	-	-	PUNCT
dti-1305	1	29	7020	7020	NUM
dti-1305	1	30	;	;	PUNCT
dti-1305	1	31	email	email	NOUN
dti-1305	1	32	:	:	PUNCT
dti-1305	1	33	faruk.khan@swoasu.edu	faruk.khan@swoasu.edu	X
dti-1305	1	34	please	please	INTJ
dti-1305	1	35	note	note	VERB
dti-1305	1	36	that	that	SCONJ
dti-1305	1	37	this	this	DET
dti-1305	1	38	article	article	NOUN
dti-1305	1	39	may	may	AUX
dti-1305	1	40	not	not	PART
dti-1305	1	41	be	be	AUX
dti-1305	1	42	used	use	VERB
dti-1305	1	43	for	for	ADP
dti-1305	1	44	commercial	commercial	ADJ
dti-1305	1	45	purposes	purpose	NOUN
dti-1305	1	46	.	.	PUNCT
dti-1305	2	1	for	for	ADP
dti-1305	2	2	further	further	ADJ
dti-1305	2	3	information	information	NOUN
dti-1305	2	4	please	please	INTJ
dti-1305	2	5	refer	refer	VERB
dti-1305	2	6	to	to	ADP
dti-1305	2	7	the	the	DET
dti-1305	2	8	copyright	copyright	NOUN
dti-1305	2	9	statement	statement	NOUN
dti-1305	2	10	at	at	ADP
dti-1305	2	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1305	2	12	trypanothione	trypanothione	NOUN
dti-1305	2	13	reductase	reductase	NOUN
dti-1305	2	14	:	:	PUNCT
dti-1305	2	15	a	a	DET
dti-1305	2	16	viable	viable	ADJ
dti-1305	2	17	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	2	18	target	target	NOUN
dti-1305	2	19	for	for	ADP
dti-1305	2	20	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	2	21	and	and	CCONJ
dti-1305	2	22	antileishmanial	antileishmanial	ADJ
dti-1305	2	23	drug	drug	NOUN
dti-1305	2	24	design	design	NOUN
dti-1305	2	25	m.	m.	NOUN
dti-1305	2	26	omar	omar	PROPN
dti-1305	2	27	f.	f.	PROPN
dti-1305	2	28	khan	khan	PROPN
dti-1305	2	29	college	college	PROPN
dti-1305	2	30	of	of	ADP
dti-1305	2	31	pharmacy	pharmacy	NOUN
dti-1305	2	32	,	,	PUNCT
dti-1305	2	33	southwestern	southwestern	ADJ
dti-1305	2	34	oklahoma	oklahoma	PROPN
dti-1305	2	35	state	state	PROPN
dti-1305	2	36	university	university	PROPN
dti-1305	2	37	,	,	PUNCT
dti-1305	2	38	100	100	NUM
dti-1305	2	39	campus	campus	NOUN
dti-1305	2	40	drive	drive	NOUN
dti-1305	2	41	,	,	PUNCT
dti-1305	2	42	weatherford	weatherford	PROPN
dti-1305	2	43	,	,	PUNCT
dti-1305	2	44	ok	ok	ADJ
dti-1305	2	45	73096	73096	NUM
dti-1305	2	46	,	,	PUNCT
dti-1305	2	47	u.s.a	u.s.a	PROPN
dti-1305	2	48	.	.	PUNCT
dti-1305	2	49	abstract	abstract	ADJ
dti-1305	2	50	:	:	PUNCT
dti-1305	2	51	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	2	52	and	and	CCONJ
dti-1305	2	53	leishmaniasis	leishmaniasis	NOUN
dti-1305	2	54	are	be	AUX
dti-1305	2	55	two	two	NUM
dti-1305	2	56	debilitating	debilitate	VERB
dti-1305	2	57	disease	disease	NOUN
dti-1305	2	58	groups	group	NOUN
dti-1305	2	59	caused	cause	VERB
dti-1305	2	60	by	by	ADP
dti-1305	2	61	parasites	parasite	NOUN
dti-1305	2	62	of	of	ADP
dti-1305	2	63	trypanosoma	trypanosoma	NOUN
dti-1305	2	64	and	and	CCONJ
dti-1305	2	65	leishmania	leishmania	NOUN
dti-1305	2	66	spp	spp	NOUN
dti-1305	2	67	.	.	PUNCT
dti-1305	3	1	and	and	CCONJ
dti-1305	3	2	affecting	affect	VERB
dti-1305	3	3	millions	million	NOUN
dti-1305	3	4	of	of	ADP
dti-1305	3	5	people	people	NOUN
dti-1305	3	6	worldwide	worldwide	ADV
dti-1305	3	7	.	.	PUNCT
dti-1305	4	1	a	a	DET
dti-1305	4	2	brief	brief	ADJ
dti-1305	4	3	outline	outline	NOUN
dti-1305	4	4	of	of	ADP
dti-1305	4	5	the	the	DET
dti-1305	4	6	potential	potential	ADJ
dti-1305	4	7	targets	target	NOUN
dti-1305	4	8	for	for	ADP
dti-1305	4	9	rational	rational	ADJ
dti-1305	4	10	drug	drug	NOUN
dti-1305	4	11	design	design	NOUN
dti-1305	4	12	against	against	ADP
dti-1305	4	13	these	these	DET
dti-1305	4	14	diseases	disease	NOUN
dti-1305	4	15	are	be	AUX
dti-1305	4	16	presented	present	VERB
dti-1305	4	17	,	,	PUNCT
dti-1305	4	18	with	with	ADP
dti-1305	4	19	an	an	DET
dti-1305	4	20	emphasis	emphasis	NOUN
dti-1305	4	21	placed	place	VERB
dti-1305	4	22	on	on	ADP
dti-1305	4	23	the	the	DET
dti-1305	4	24	enzyme	enzyme	NOUN
dti-1305	4	25	trypanothione	trypanothione	NOUN
dti-1305	4	26	reductase	reductase	NOUN
dti-1305	4	27	.	.	PUNCT
dti-1305	5	1	trypanothione	trypanothione	ADJ
dti-1305	5	2	reductase	reductase	NOUN
dti-1305	5	3	was	be	AUX
dti-1305	5	4	identifi	identifi	PROPN
dti-1305	5	5	ed	ed	NOUN
dti-1305	5	6	as	as	ADV
dti-1305	5	7	unique	unique	ADJ
dti-1305	5	8	to	to	ADP
dti-1305	5	9	parasites	parasite	NOUN
dti-1305	5	10	and	and	CCONJ
dti-1305	5	11	proposed	propose	VERB
dti-1305	5	12	to	to	PART
dti-1305	5	13	be	be	AUX
dti-1305	5	14	an	an	DET
dti-1305	5	15	effective	effective	ADJ
dti-1305	5	16	target	target	NOUN
dti-1305	5	17	against	against	ADP
dti-1305	5	18	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	5	19	and	and	CCONJ
dti-1305	5	20	leishmaniasis	leishmaniasis	NOUN
dti-1305	5	21	.	.	PUNCT
dti-1305	6	1	the	the	DET
dti-1305	6	2	biochemical	biochemical	ADJ
dti-1305	6	3	basis	basis	NOUN
dti-1305	6	4	of	of	ADP
dti-1305	6	5	selecting	select	VERB
dti-1305	6	6	this	this	DET
dti-1305	6	7	enzyme	enzyme	NOUN
dti-1305	6	8	as	as	ADP
dti-1305	6	9	a	a	DET
dti-1305	6	10	target	target	NOUN
dti-1305	6	11	,	,	PUNCT
dti-1305	6	12	with	with	ADP
dti-1305	6	13	reference	reference	NOUN
dti-1305	6	14	to	to	ADP
dti-1305	6	15	the	the	DET
dti-1305	6	16	simile	simile	NOUN
dti-1305	6	17	and	and	CCONJ
dti-1305	6	18	contrast	contrast	NOUN
dti-1305	6	19	to	to	ADP
dti-1305	6	20	human	human	ADJ
dti-1305	6	21	analogous	analogous	ADJ
dti-1305	6	22	enzyme	enzyme	NOUN
dti-1305	6	23	glutathione	glutathione	NOUN
dti-1305	6	24	reductase	reductase	NOUN
dti-1305	6	25	,	,	PUNCT
dti-1305	6	26	and	and	CCONJ
dti-1305	6	27	the	the	DET
dti-1305	6	28	structural	structural	ADJ
dti-1305	6	29	aspects	aspect	NOUN
dti-1305	6	30	of	of	ADP
dti-1305	6	31	its	its	PRON
dti-1305	6	32	active	active	ADJ
dti-1305	6	33	site	site	NOUN
dti-1305	6	34	are	be	AUX
dti-1305	6	35	presented	present	VERB
dti-1305	6	36	.	.	PUNCT
dti-1305	7	1	the	the	DET
dti-1305	7	2	process	process	NOUN
dti-1305	7	3	of	of	ADP
dti-1305	7	4	designing	design	VERB
dti-1305	7	5	selective	selective	ADJ
dti-1305	7	6	inhibitors	inhibitor	NOUN
dti-1305	7	7	for	for	ADP
dti-1305	7	8	the	the	DET
dti-1305	7	9	enzyme	enzyme	NOUN
dti-1305	7	10	trypanothione	trypanothione	NOUN
dti-1305	7	11	reductase	reductase	NOUN
dti-1305	7	12	has	have	AUX
dti-1305	7	13	been	be	AUX
dti-1305	7	14	discussed	discuss	VERB
dti-1305	7	15	.	.	PUNCT
dti-1305	8	1	an	an	DET
dti-1305	8	2	overview	overview	NOUN
dti-1305	8	3	of	of	ADP
dti-1305	8	4	the	the	DET
dti-1305	8	5	different	different	ADJ
dti-1305	8	6	chemical	chemical	NOUN
dti-1305	8	7	classes	class	NOUN
dti-1305	8	8	of	of	ADP
dti-1305	8	9	inhibitors	inhibitor	NOUN
dti-1305	8	10	of	of	ADP
dti-1305	8	11	trypanothione	trypanothione	NOUN
dti-1305	8	12	reductase	reductase	NOUN
dti-1305	8	13	with	with	ADP
dti-1305	8	14	their	their	PRON
dti-1305	8	15	inhibitory	inhibitory	ADJ
dti-1305	8	16	activities	activity	NOUN
dti-1305	8	17	against	against	ADP
dti-1305	8	18	the	the	DET
dti-1305	8	19	parasites	parasite	NOUN
dti-1305	8	20	and	and	CCONJ
dti-1305	8	21	their	their	PRON
dti-1305	8	22	prospects	prospect	NOUN
dti-1305	8	23	as	as	ADP
dti-1305	8	24	future	future	ADJ
dti-1305	8	25	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	8	26	agents	agent	NOUN
dti-1305	8	27	are	be	AUX
dti-1305	8	28	briefl	briefl	NOUN
dti-1305	8	29	y	y	PRON
dti-1305	8	30	revealed	reveal	VERB
dti-1305	8	31	.	.	PUNCT
dti-1305	9	1	key	key	ADJ
dti-1305	9	2	words	word	NOUN
dti-1305	9	3	:	:	PUNCT
dti-1305	9	4	trypanothione	trypanothione	ADJ
dti-1305	9	5	,	,	PUNCT
dti-1305	9	6	glutathione	glutathione	NOUN
dti-1305	9	7	,	,	PUNCT
dti-1305	9	8	chagas	chagas	NOUN
dti-1305	9	9	disease	disease	NOUN
dti-1305	9	10	,	,	PUNCT
dti-1305	9	11	sleeping	sleep	VERB
dti-1305	9	12	sickness	sickness	NOUN
dti-1305	9	13	,	,	PUNCT
dti-1305	9	14	rational	rational	ADJ
dti-1305	9	15	drug	drug	NOUN
dti-1305	9	16	design	design	NOUN
dti-1305	9	17	introduction	introduction	NOUN
dti-1305	9	18	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	9	19	and	and	CCONJ
dti-1305	9	20	leishmaniasis	leishmaniasis	NOUN
dti-1305	9	21	are	be	AUX
dti-1305	9	22	among	among	ADP
dti-1305	9	23	the	the	DET
dti-1305	9	24	major	major	ADJ
dti-1305	9	25	debilitating	debilitating	ADJ
dti-1305	9	26	and	and	CCONJ
dti-1305	9	27	devastating	devastating	ADJ
dti-1305	9	28	tropical	tropical	ADJ
dti-1305	9	29	diseases	disease	NOUN
dti-1305	9	30	that	that	PRON
dti-1305	9	31	are	be	AUX
dti-1305	9	32	targets	target	NOUN
dti-1305	9	33	for	for	ADP
dti-1305	9	34	the	the	DET
dti-1305	9	35	world	world	PROPN
dti-1305	9	36	health	health	PROPN
dti-1305	9	37	organization	organization	PROPN
dti-1305	9	38	’s	’s	PART
dti-1305	9	39	special	special	ADJ
dti-1305	9	40	program	program	NOUN
dti-1305	9	41	research	research	NOUN
dti-1305	9	42	and	and	CCONJ
dti-1305	9	43	training	training	NOUN
dti-1305	9	44	in	in	ADP
dti-1305	9	45	tropical	tropical	ADJ
dti-1305	9	46	diseases	disease	NOUN
dti-1305	9	47	(	(	PUNCT
dti-1305	9	48	tdr	tdr	PROPN
dti-1305	9	49	)	)	PUNCT
dti-1305	9	50	(	(	PUNCT
dti-1305	9	51	hyde	hyde	PROPN
dti-1305	9	52	,	,	PUNCT
dti-1305	9	53	1990	1990	NUM
dti-1305	9	54	)	)	PUNCT
dti-1305	9	55	and	and	CCONJ
dti-1305	9	56	most	most	ADV
dti-1305	9	57	recently	recently	ADV
dti-1305	9	58	the	the	DET
dti-1305	9	59	drugs	drug	NOUN
dti-1305	9	60	for	for	ADP
dti-1305	9	61	neglected	neglect	VERB
dti-1305	9	62	diseases	disease	NOUN
dti-1305	9	63	initiative	initiative	NOUN
dti-1305	9	64	(	(	PUNCT
dti-1305	9	65	dndi	dndi	NOUN
dti-1305	9	66	,	,	PUNCT
dti-1305	9	67	www.dndi.org	www.dndi.org	NOUN
dti-1305	9	68	)	)	PUNCT
dti-1305	9	69	.	.	PUNCT
dti-1305	10	1	these	these	DET
dti-1305	10	2	diseases	disease	NOUN
dti-1305	10	3	are	be	AUX
dti-1305	10	4	caused	cause	VERB
dti-1305	10	5	by	by	ADP
dti-1305	10	6	the	the	DET
dti-1305	10	7	parasites	parasite	NOUN
dti-1305	10	8	of	of	ADP
dti-1305	10	9	the	the	DET
dti-1305	10	10	genus	genus	ADJ
dti-1305	10	11	trypanosoma	trypanosoma	NOUN
dti-1305	10	12	and	and	CCONJ
dti-1305	10	13	leishmania	leishmania	NOUN
dti-1305	10	14	.	.	PUNCT
dti-1305	11	1	the	the	DET
dti-1305	11	2	present	present	ADJ
dti-1305	11	3	review	review	NOUN
dti-1305	11	4	focuses	focus	VERB
dti-1305	11	5	on	on	ADP
dti-1305	11	6	the	the	DET
dti-1305	11	7	major	major	ADJ
dti-1305	11	8	human	human	ADJ
dti-1305	11	9	diseases	disease	NOUN
dti-1305	11	10	caused	cause	VERB
dti-1305	11	11	by	by	ADP
dti-1305	11	12	trypanosomal	trypanosomal	ADJ
dti-1305	11	13	and	and	CCONJ
dti-1305	11	14	leishmanial	leishmanial	ADJ
dti-1305	11	15	infections	infection	NOUN
dti-1305	11	16	and	and	CCONJ
dti-1305	11	17	the	the	DET
dti-1305	11	18	potential	potential	ADJ
dti-1305	11	19	targets	target	NOUN
dti-1305	11	20	for	for	ADP
dti-1305	11	21	designing	design	VERB
dti-1305	11	22	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	11	23	agents	agent	NOUN
dti-1305	11	24	against	against	ADP
dti-1305	11	25	these	these	DET
dti-1305	11	26	diseases	disease	NOUN
dti-1305	11	27	with	with	ADP
dti-1305	11	28	special	special	ADJ
dti-1305	11	29	emphasis	emphasis	NOUN
dti-1305	11	30	on	on	ADP
dti-1305	11	31	trypanothione	trypanothione	PROPN
dti-1305	11	32	reductase	reductase	NOUN
dti-1305	11	33	.	.	PUNCT
dti-1305	12	1	table	table	NOUN
dti-1305	12	2	1	1	NUM
dti-1305	12	3	gives	give	VERB
dti-1305	12	4	an	an	DET
dti-1305	12	5	outline	outline	NOUN
dti-1305	12	6	of	of	ADP
dti-1305	12	7	the	the	DET
dti-1305	12	8	major	major	ADJ
dti-1305	12	9	human	human	ADJ
dti-1305	12	10	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	12	11	and	and	CCONJ
dti-1305	12	12	leishmaniasis	leishmaniasis	NOUN
dti-1305	12	13	with	with	ADP
dti-1305	12	14	their	their	PRON
dti-1305	12	15	global	global	ADJ
dti-1305	12	16	annual	annual	ADJ
dti-1305	12	17	disease	disease	NOUN
dti-1305	12	18	burdens	burden	NOUN
dti-1305	12	19	(	(	PUNCT
dti-1305	12	20	as	as	ADP
dti-1305	12	21	of	of	ADP
dti-1305	12	22	1999	1999	NUM
dti-1305	12	23	)	)	PUNCT
dti-1305	12	24	in	in	ADP
dti-1305	12	25	terms	term	NOUN
dti-1305	12	26	of	of	ADP
dti-1305	12	27	disability	disability	NOUN
dti-1305	12	28	adjusted	adjust	VERB
dti-1305	12	29	life	life	NOUN
dti-1305	12	30	years	year	NOUN
dti-1305	12	31	(	(	PUNCT
dti-1305	12	32	daly	daly	NOUN
dti-1305	12	33	)	)	PUNCT
dti-1305	12	34	.	.	PUNCT
dti-1305	13	1	table	table	NOUN
dti-1305	13	2	1.the	1.the	PRON
dti-1305	13	3	major	major	ADJ
dti-1305	13	4	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	13	5	and	and	CCONJ
dti-1305	13	6	leishmaniasis	leishmaniasis	NOUN
dti-1305	13	7	,	,	PUNCT
dti-1305	13	8	causative	causative	ADJ
dti-1305	13	9	agents	agent	NOUN
dti-1305	13	10	,	,	PUNCT
dti-1305	13	11	their	their	PRON
dti-1305	13	12	global	global	ADJ
dti-1305	13	13	burdens	burden	NOUN
dti-1305	13	14	in	in	ADP
dti-1305	13	15	terms	term	NOUN
dti-1305	13	16	of	of	ADP
dti-1305	13	17	disability	disability	NOUN
dti-1305	13	18	adjusted	adjust	VERB
dti-1305	13	19	life	life	NOUN
dti-1305	13	20	years	year	NOUN
dti-1305	13	21	(	(	PUNCT
dti-1305	13	22	daly	daly	NOUN
dti-1305	13	23	)	)	PUNCT
dti-1305	13	24	and	and	CCONJ
dti-1305	13	25	current	current	ADJ
dti-1305	13	26	treatments	treatment	NOUN
dti-1305	13	27	.	.	PUNCT
dti-1305	14	1	disease	disease	NOUN
dti-1305	14	2	causative	causative	PROPN
dti-1305	14	3	agents	agent	NOUN
dti-1305	14	4	daly	daly	PROPN
dti-1305	14	5	*	*	PUNCT
dti-1305	14	6	current	current	ADJ
dti-1305	14	7	treatments	treatment	NOUN
dti-1305	14	8	(	(	PUNCT
dti-1305	14	9	million	million	NUM
dti-1305	14	10	/	/	SYM
dti-1305	14	11	year	year	NOUN
dti-1305	14	12	)	)	PUNCT
dti-1305	14	13	african	african	PROPN
dti-1305	14	14	trypanosoma	trypanosoma	PROPN
dti-1305	14	15	brucei	brucei	PROPN
dti-1305	14	16	1.2	1.2	NUM
dti-1305	14	17	suramine	suramine	NOUN
dti-1305	14	18	,	,	PUNCT
dti-1305	14	19	pentamidine	pentamidine	VERB
dti-1305	14	20	,	,	PUNCT
dti-1305	14	21	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	14	22	gambiense	gambiense	NOUN
dti-1305	14	23	and	and	CCONJ
dti-1305	14	24	dfmo	dfmo	NOUN
dti-1305	14	25	,	,	PUNCT
dti-1305	14	26	tryparsamide	tryparsamide	NOUN
dti-1305	14	27	or	or	CCONJ
dti-1305	14	28	sleeping	sleep	VERB
dti-1305	15	1	t.	t.	PROPN
dti-1305	15	2	b.	b.	PROPN
dti-1305	15	3	rhodesiense	rhodesiense	PROPN
dti-1305	15	4	sickness	sickness	PROPN
dti-1305	15	5	american	american	PROPN
dti-1305	15	6	t.	t.	PROPN
dti-1305	15	7	cruzi	cruzi	PROPN
dti-1305	15	8	0.6	0.6	NUM
dti-1305	15	9	benznidazole	benznidazole	NOUN
dti-1305	15	10	,	,	PUNCT
dti-1305	15	11	nifurtimox	nifurtimox	PROPN
dti-1305	15	12	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	15	13	or	or	CCONJ
dti-1305	15	14	chagas	chagas	NOUN
dti-1305	15	15	disease	disease	NOUN
dti-1305	15	16	visceral	visceral	ADJ
dti-1305	15	17	leishmania	leishmania	NOUN
dti-1305	15	18	donovani	donovani	VERB
dti-1305	15	19	1.7	1.7	NUM
dti-1305	15	20	pentostam	pentostam	NOUN
dti-1305	15	21	,	,	PUNCT
dti-1305	15	22	glucantime	glucantime	ADJ
dti-1305	15	23	,	,	PUNCT
dti-1305	15	24	leishmaniasis	leishmaniasis	NOUN
dti-1305	15	25	or	or	CCONJ
dti-1305	15	26	kalazar	kalazar	NOUN
dti-1305	15	27	dermal	dermal	VERB
dti-1305	15	28	l.	l.	PROPN
dti-1305	15	29	major	major	PROPN
dti-1305	15	30	,	,	PUNCT
dti-1305	15	31	l.	l.	PROPN
dti-1305	15	32	tropica	tropica	PROPN
dti-1305	15	33	,	,	PUNCT
dti-1305	15	34	aminosidine	aminosidine	ADJ
dti-1305	15	35	leishmaniasis	leishmaniasis	NOUN
dti-1305	15	36	l.	l.	PROPN
dti-1305	15	37	braziliensis	braziliensis	PROPN
dti-1305	15	38	,	,	PUNCT
dti-1305	15	39	l.	l.	PROPN
dti-1305	15	40	mexicana	mexicana	PROPN
dti-1305	15	41	or	or	CCONJ
dti-1305	15	42	tropical	tropical	ADJ
dti-1305	15	43	sore	sore	NOUN
dti-1305	15	44	*	*	PUNCT
dti-1305	15	45	taken	take	VERB
dti-1305	15	46	from	from	ADP
dti-1305	15	47	world	world	NOUN
dti-1305	15	48	health	health	NOUN
dti-1305	15	49	report	report	NOUN
dti-1305	15	50	1999	1999	NUM
dti-1305	15	51	,	,	PUNCT
dti-1305	15	52	publ	publ	PROPN
dti-1305	15	53	.	.	PUNCT
dti-1305	16	1	world	world	PROPN
dti-1305	16	2	health	health	PROPN
dti-1305	16	3	organization	organization	PROPN
dti-1305	16	4	geneva	geneva	PROPN
dti-1305	16	5	(	(	PUNCT
dti-1305	16	6	1999	1999	NUM
dti-1305	16	7	)	)	PUNCT
dti-1305	16	8	.	.	PUNCT
dti-1305	17	1	drug	drug	NOUN
dti-1305	17	2	target	target	NOUN
dti-1305	17	3	insights	insight	NOUN
dti-1305	17	4	2007	2007	NUM
dti-1305	17	5	:	:	PUNCT
dti-1305	17	6	2	2	NUM
dti-1305	17	7	129–146	129–146	NUM
dti-1305	17	8	130	130	NUM
dti-1305	17	9	khan	khan	PROPN
dti-1305	17	10	suramine	suramine	NOUN
dti-1305	17	11	(	(	PUNCT
dti-1305	17	12	1	1	NUM
dti-1305	17	13	)	)	PUNCT
dti-1305	17	14	and	and	CCONJ
dti-1305	17	15	pentamidine	pentamidine	ADJ
dti-1305	17	16	(	(	PUNCT
dti-1305	17	17	2	2	X
dti-1305	17	18	)	)	PUNCT
dti-1305	17	19	are	be	AUX
dti-1305	17	20	useful	useful	ADJ
dti-1305	17	21	drugs	drug	NOUN
dti-1305	17	22	for	for	ADP
dti-1305	17	23	treating	treat	VERB
dti-1305	17	24	human	human	ADJ
dti-1305	17	25	african	african	ADJ
dti-1305	17	26	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	17	27	(	(	PUNCT
dti-1305	17	28	hat	hat	NOUN
dti-1305	17	29	)	)	PUNCT
dti-1305	17	30	during	during	ADP
dti-1305	17	31	early	early	ADJ
dti-1305	17	32	infection	infection	NOUN
dti-1305	17	33	,	,	PUNCT
dti-1305	17	34	but	but	CCONJ
dti-1305	17	35	being	be	AUX
dti-1305	17	36	highly	highly	ADV
dti-1305	17	37	charged	charge	VERB
dti-1305	17	38	,	,	PUNCT
dti-1305	17	39	can	can	AUX
dti-1305	17	40	not	not	PART
dti-1305	17	41	cross	cross	VERB
dti-1305	17	42	the	the	DET
dti-1305	17	43	blood	blood	NOUN
dti-1305	17	44	brain	brain	NOUN
dti-1305	17	45	barrier	barrier	NOUN
dti-1305	17	46	and	and	CCONJ
dti-1305	17	47	are	be	AUX
dti-1305	17	48	of	of	ADP
dti-1305	17	49	no	no	DET
dti-1305	17	50	use	use	NOUN
dti-1305	17	51	for	for	ADP
dti-1305	17	52	late	late	ADJ
dti-1305	17	53	stage	stage	NOUN
dti-1305	17	54	infection	infection	NOUN
dti-1305	17	55	with	with	ADP
dti-1305	17	56	involvement	involvement	NOUN
dti-1305	17	57	of	of	ADP
dti-1305	17	58	central	central	ADJ
dti-1305	17	59	nervous	nervous	ADJ
dti-1305	17	60	system	system	NOUN
dti-1305	17	61	(	(	PUNCT
dti-1305	17	62	cns	cns	NOUN
dti-1305	17	63	)	)	PUNCT
dti-1305	17	64	with	with	ADP
dti-1305	17	65	either	either	CCONJ
dti-1305	17	66	trypanosoma	trypanosoma	PROPN
dti-1305	17	67	brucei	brucei	PROPN
dti-1305	17	68	gambiense	gambiense	PROPN
dti-1305	17	69	or	or	CCONJ
dti-1305	17	70	t.	t.	PROPN
dti-1305	17	71	b.	b.	PROPN
dti-1305	17	72	rhodesiense	rhodesiense	PROPN
dti-1305	17	73	.	.	PUNCT
dti-1305	18	1	melarsoprol	melarsoprol	PROPN
dti-1305	18	2	(	(	PUNCT
dti-1305	18	3	3	3	NUM
dti-1305	18	4	)	)	PUNCT
dti-1305	18	5	,	,	PUNCT
dti-1305	18	6	a	a	DET
dti-1305	18	7	trivalent	trivalent	NOUN
dti-1305	18	8	arsenical	arsenical	ADJ
dti-1305	18	9	,	,	PUNCT
dti-1305	18	10	or	or	CCONJ
dti-1305	18	11	tryparsamide	tryparsamide	NOUN
dti-1305	18	12	(	(	PUNCT
dti-1305	18	13	4	4	NUM
dti-1305	18	14	)	)	PUNCT
dti-1305	18	15	is	be	AUX
dti-1305	18	16	then	then	ADV
dti-1305	18	17	used	use	VERB
dti-1305	18	18	.	.	PUNCT
dti-1305	19	1	difl	difl	PROPN
dti-1305	19	2	uoromethylornithine	uoromethylornithine	PROPN
dti-1305	19	3	(	(	PUNCT
dti-1305	19	4	dfmo	dfmo	NOUN
dti-1305	19	5	,	,	PUNCT
dti-1305	19	6	5	5	NUM
dti-1305	19	7	)	)	PUNCT
dti-1305	19	8	is	be	AUX
dti-1305	19	9	effective	effective	ADJ
dti-1305	19	10	in	in	ADP
dti-1305	19	11	treatment	treatment	NOUN
dti-1305	19	12	of	of	ADP
dti-1305	19	13	hat	hat	NOUN
dti-1305	19	14	,	,	PUNCT
dti-1305	19	15	but	but	CCONJ
dti-1305	19	16	is	be	AUX
dti-1305	19	17	not	not	PART
dti-1305	19	18	very	very	ADV
dti-1305	19	19	effective	effective	ADJ
dti-1305	19	20	against	against	ADP
dti-1305	19	21	rhodesiense	rhodesiense	NOUN
dti-1305	19	22	sleeping	sleep	VERB
dti-1305	19	23	sickness	sickness	NOUN
dti-1305	19	24	where	where	SCONJ
dti-1305	19	25	large	large	ADJ
dti-1305	19	26	doses	dose	NOUN
dti-1305	19	27	must	must	AUX
dti-1305	19	28	be	be	AUX
dti-1305	19	29	used	use	VERB
dti-1305	19	30	,	,	PUNCT
dti-1305	19	31	resulting	result	VERB
dti-1305	19	32	in	in	ADP
dti-1305	19	33	significant	significant	ADJ
dti-1305	19	34	side	side	NOUN
dti-1305	19	35	-	-	PUNCT
dti-1305	19	36	effects	effect	NOUN
dti-1305	19	37	,	,	PUNCT
dti-1305	19	38	including	include	VERB
dti-1305	19	39	bone	bone	NOUN
dti-1305	19	40	marrow	marrow	NOUN
dti-1305	19	41	suppression	suppression	NOUN
dti-1305	19	42	(	(	PUNCT
dti-1305	19	43	meshnick	meshnick	PROPN
dti-1305	19	44	,	,	PUNCT
dti-1305	19	45	1984	1984	NUM
dti-1305	19	46	;	;	PUNCT
dti-1305	19	47	neva	neva	PROPN
dti-1305	19	48	and	and	CCONJ
dti-1305	19	49	brown	brown	ADJ
dti-1305	19	50	,	,	PUNCT
dti-1305	19	51	1994	1994	NUM
dti-1305	19	52	)	)	PUNCT
dti-1305	19	53	.	.	PUNCT
dti-1305	20	1	nifurtimox	nifurtimox	PROPN
dti-1305	20	2	(	(	PUNCT
dti-1305	20	3	6	6	NUM
dti-1305	20	4	)	)	PUNCT
dti-1305	20	5	,	,	PUNCT
dti-1305	20	6	a	a	DET
dti-1305	20	7	nitrofuran	nitrofuran	NOUN
dti-1305	20	8	derivative	derivative	NOUN
dti-1305	20	9	,	,	PUNCT
dti-1305	20	10	is	be	AUX
dti-1305	20	11	the	the	DET
dti-1305	20	12	best	good	ADJ
dti-1305	20	13	drug	drug	NOUN
dti-1305	20	14	currently	currently	ADV
dti-1305	20	15	available	available	ADJ
dti-1305	20	16	for	for	ADP
dti-1305	20	17	treating	treat	VERB
dti-1305	20	18	chagas	chagas	NOUN
dti-1305	20	19	disease	disease	NOUN
dti-1305	20	20	but	but	CCONJ
dti-1305	20	21	is	be	AUX
dti-1305	20	22	still	still	ADV
dti-1305	20	23	considered	consider	VERB
dti-1305	20	24	investigational	investigational	ADJ
dti-1305	20	25	.	.	PUNCT
dti-1305	21	1	it	it	PRON
dti-1305	21	2	is	be	AUX
dti-1305	21	3	thought	think	VERB
dti-1305	21	4	to	to	PART
dti-1305	21	5	kill	kill	VERB
dti-1305	21	6	trypanosomes	trypanosome	NOUN
dti-1305	21	7	selectively	selectively	ADV
dti-1305	21	8	through	through	ADP
dti-1305	21	9	futile	futile	ADJ
dti-1305	21	10	cycling	cycling	NOUN
dti-1305	21	11	by	by	ADP
dti-1305	21	12	the	the	DET
dti-1305	21	13	formation	formation	NOUN
dti-1305	21	14	of	of	ADP
dti-1305	21	15	hydrogen	hydrogen	NOUN
dti-1305	21	16	peroxide	peroxide	NOUN
dti-1305	21	17	and	and	CCONJ
dti-1305	21	18	toxic	toxic	ADJ
dti-1305	21	19	oxygen	oxygen	NOUN
dti-1305	21	20	species	specie	NOUN
dti-1305	21	21	(	(	PUNCT
dti-1305	21	22	docampo	docampo	NOUN
dti-1305	21	23	and	and	CCONJ
dti-1305	21	24	stoppani	stoppani	NOUN
dti-1305	21	25	,	,	PUNCT
dti-1305	21	26	1979	1979	NUM
dti-1305	21	27	;	;	PUNCT
dti-1305	21	28	le	le	PROPN
dti-1305	21	29	trant	trant	PROPN
dti-1305	21	30	et	et	PROPN
dti-1305	21	31	al	al	PROPN
dti-1305	21	32	.	.	PROPN
dti-1305	21	33	1983	1983	NUM
dti-1305	21	34	;	;	PUNCT
dti-1305	21	35	docampo	docampo	PROPN
dti-1305	21	36	and	and	CCONJ
dti-1305	21	37	moreno	moreno	PROPN
dti-1305	21	38	,	,	PUNCT
dti-1305	21	39	1984a	1984a	NUM
dti-1305	21	40	and	and	CCONJ
dti-1305	21	41	b	b	NOUN
dti-1305	21	42	,	,	PUNCT
dti-1305	21	43	1986	1986	NUM
dti-1305	21	44	;	;	PUNCT
dti-1305	21	45	neva	neva	PROPN
dti-1305	21	46	and	and	CCONJ
dti-1305	21	47	brown	brown	ADJ
dti-1305	21	48	,	,	PUNCT
dti-1305	21	49	1994	1994	NUM
dti-1305	21	50	)	)	PUNCT
dti-1305	21	51	.	.	PUNCT
dti-1305	22	1	benznidazole	benznidazole	NOUN
dti-1305	22	2	(	(	PUNCT
dti-1305	22	3	7	7	X
dti-1305	22	4	)	)	PUNCT
dti-1305	22	5	is	be	AUX
dti-1305	22	6	of	of	ADP
dti-1305	22	7	equivalent	equivalent	ADJ
dti-1305	22	8	effectiveness	effectiveness	NOUN
dti-1305	22	9	and	and	CCONJ
dti-1305	22	10	is	be	AUX
dti-1305	22	11	used	use	VERB
dti-1305	22	12	in	in	ADP
dti-1305	22	13	south	south	PROPN
dti-1305	22	14	america	america	PROPN
dti-1305	22	15	in	in	ADP
dti-1305	22	16	the	the	DET
dti-1305	22	17	acute	acute	ADJ
dti-1305	22	18	stage	stage	NOUN
dti-1305	22	19	.	.	PUNCT
dti-1305	23	1	both	both	DET
dti-1305	23	2	drugs	drug	NOUN
dti-1305	23	3	must	must	AUX
dti-1305	23	4	be	be	AUX
dti-1305	23	5	given	give	VERB
dti-1305	23	6	for	for	ADP
dti-1305	23	7	several	several	ADJ
dti-1305	23	8	months	month	NOUN
dti-1305	23	9	and	and	CCONJ
dti-1305	23	10	are	be	AUX
dti-1305	23	11	associated	associate	VERB
dti-1305	23	12	with	with	ADP
dti-1305	23	13	severe	severe	ADJ
dti-1305	23	14	side	side	NOUN
dti-1305	23	15	effects	effect	NOUN
dti-1305	23	16	(	(	PUNCT
dti-1305	23	17	neva	neva	X
dti-1305	23	18	and	and	CCONJ
dti-1305	23	19	brown	brown	ADJ
dti-1305	23	20	,	,	PUNCT
dti-1305	23	21	1994	1994	NUM
dti-1305	23	22	)	)	PUNCT
dti-1305	23	23	.	.	PUNCT
dti-1305	24	1	recently	recently	ADV
dti-1305	24	2	,	,	PUNCT
dti-1305	24	3	the	the	DET
dti-1305	24	4	present	present	ADJ
dti-1305	24	5	and	and	CCONJ
dti-1305	24	6	future	future	ADJ
dti-1305	24	7	prospects	prospect	NOUN
dti-1305	24	8	of	of	ADP
dti-1305	24	9	chemotherapy	chemotherapy	NOUN
dti-1305	24	10	of	of	ADP
dti-1305	24	11	hat	hat	NOUN
dti-1305	24	12	,	,	PUNCT
dti-1305	24	13	in	in	ADP
dti-1305	24	14	addition	addition	NOUN
dti-1305	24	15	to	to	ADP
dti-1305	24	16	the	the	DET
dti-1305	24	17	possible	possible	ADJ
dti-1305	24	18	mode	mode	NOUN
dti-1305	24	19	of	of	ADP
dti-1305	24	20	action	action	NOUN
dti-1305	24	21	and	and	CCONJ
dti-1305	24	22	the	the	DET
dti-1305	24	23	mechanism	mechanism	NOUN
dti-1305	24	24	of	of	ADP
dti-1305	24	25	resistance	resistance	NOUN
dti-1305	24	26	of	of	ADP
dti-1305	24	27	the	the	DET
dti-1305	24	28	current	current	ADJ
dti-1305	24	29	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	24	30	agents	agent	NOUN
dti-1305	24	31	have	have	AUX
dti-1305	24	32	been	be	AUX
dti-1305	24	33	reviewed	review	VERB
dti-1305	24	34	(	(	PUNCT
dti-1305	24	35	fairlamb	fairlamb	NOUN
dti-1305	24	36	,	,	PUNCT
dti-1305	24	37	2003a	2003a	NUM
dti-1305	24	38	)	)	PUNCT
dti-1305	24	39	.	.	PUNCT
dti-1305	25	1	pentavalent	pentavalent	NOUN
dti-1305	25	2	antimonials	antimonial	NOUN
dti-1305	25	3	e.g.	e.g.	ADV
dti-1305	25	4	pentostam	pentostam	NOUN
dti-1305	25	5	(	(	PUNCT
dti-1305	25	6	8)	8)	NUM
dti-1305	25	7	is	be	AUX
dti-1305	25	8	the	the	DET
dti-1305	25	9	recommended	recommend	VERB
dti-1305	25	10	treatment	treatment	NOUN
dti-1305	25	11	for	for	ADP
dti-1305	25	12	visceral	visceral	ADJ
dti-1305	25	13	leishmaniasis	leishmaniasis	NOUN
dti-1305	25	14	but	but	CCONJ
dti-1305	25	15	are	be	AUX
dti-1305	25	16	toxic	toxic	ADJ
dti-1305	25	17	and	and	CCONJ
dti-1305	25	18	developed	develop	VERB
dti-1305	25	19	resistance	resistance	NOUN
dti-1305	25	20	(	(	PUNCT
dti-1305	25	21	croft	croft	PROPN
dti-1305	25	22	,	,	PUNCT
dti-1305	25	23	1988	1988	NUM
dti-1305	25	24	;	;	PUNCT
dti-1305	25	25	grogl	grogl	NOUN
dti-1305	25	26	et	et	PROPN
dti-1305	25	27	al	al	PROPN
dti-1305	25	28	.	.	PROPN
dti-1305	25	29	1992	1992	NUM
dti-1305	25	30	)	)	PUNCT
dti-1305	25	31	.	.	PUNCT
dti-1305	26	1	relapse	relapse	NOUN
dti-1305	26	2	of	of	ADP
dti-1305	26	3	disease	disease	NOUN
dti-1305	26	4	or	or	CCONJ
dti-1305	26	5	only	only	ADV
dti-1305	26	6	partial	partial	ADJ
dti-1305	26	7	response	response	NOUN
dti-1305	26	8	is	be	AUX
dti-1305	26	9	more	more	ADV
dti-1305	26	10	common	common	ADJ
dti-1305	26	11	in	in	ADP
dti-1305	26	12	kenya	kenya	PROPN
dti-1305	26	13	,	,	PUNCT
dti-1305	26	14	the	the	DET
dti-1305	26	15	sudan	sudan	PROPN
dti-1305	26	16	,	,	PUNCT
dti-1305	26	17	and	and	CCONJ
dti-1305	26	18	india	india	PROPN
dti-1305	26	19	than	than	ADP
dti-1305	26	20	in	in	ADP
dti-1305	26	21	mediterranean	mediterranean	PROPN
dti-1305	26	22	or	or	CCONJ
dti-1305	26	23	latin	latin	PROPN
dti-1305	26	24	american	american	PROPN
dti-1305	26	25	kala	kala	PROPN
dti-1305	26	26	azar	azar	PROPN
dti-1305	26	27	,	,	PUNCT
dti-1305	26	28	where	where	SCONJ
dti-1305	26	29	a	a	DET
dti-1305	26	30	second	second	ADJ
dti-1305	26	31	or	or	CCONJ
dti-1305	26	32	longer	long	ADJ
dti-1305	26	33	course	course	NOUN
dti-1305	26	34	of	of	ADP
dti-1305	26	35	treatment	treatment	NOUN
dti-1305	26	36	is	be	AUX
dti-1305	26	37	often	often	ADV
dti-1305	26	38	needed	need	VERB
dti-1305	26	39	.	.	PUNCT
dti-1305	27	1	overall	overall	ADV
dti-1305	27	2	,	,	PUNCT
dti-1305	27	3	the	the	DET
dti-1305	27	4	demand	demand	NOUN
dti-1305	27	5	for	for	ADP
dti-1305	27	6	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	27	7	agents	agent	NOUN
dti-1305	27	8	for	for	ADP
dti-1305	27	9	the	the	DET
dti-1305	27	10	treatment	treatment	NOUN
dti-1305	27	11	of	of	ADP
dti-1305	27	12	chagas	chagas	NOUN
dti-1305	27	13	disease	disease	NOUN
dti-1305	27	14	,	,	PUNCT
dti-1305	27	15	sleeping	sleep	VERB
dti-1305	27	16	sickness	sickness	NOUN
dti-1305	27	17	and	and	CCONJ
dti-1305	27	18	kala	kala	PROPN
dti-1305	27	19	azar	azar	PROPN
dti-1305	27	20	is	be	AUX
dti-1305	27	21	desperate	desperate	ADJ
dti-1305	27	22	.	.	PUNCT
dti-1305	28	1	those	those	PRON
dti-1305	28	2	needing	need	VERB
dti-1305	28	3	treatment	treatment	NOUN
dti-1305	28	4	are	be	AUX
dti-1305	28	5	mainly	mainly	ADV
dti-1305	28	6	in	in	ADP
dti-1305	28	7	impoverished	impoverished	ADJ
dti-1305	28	8	rural	rural	ADJ
dti-1305	28	9	and	and	CCONJ
dti-1305	28	10	urban	urban	ADJ
dti-1305	28	11	communities	community	NOUN
dti-1305	28	12	with	with	ADP
dti-1305	28	13	poor	poor	ADJ
dti-1305	28	14	housing	housing	NOUN
dti-1305	28	15	and	and	CCONJ
dti-1305	28	16	limited	limited	ADJ
dti-1305	28	17	access	access	NOUN
dti-1305	28	18	to	to	ADP
dti-1305	28	19	medical	medical	ADJ
dti-1305	28	20	attention	attention	NOUN
dti-1305	28	21	,	,	PUNCT
dti-1305	28	22	and	and	CCONJ
dti-1305	28	23	in	in	ADP
dti-1305	28	24	countries	country	NOUN
dti-1305	28	25	where	where	SCONJ
dti-1305	28	26	basic	basic	ADJ
dti-1305	28	27	healthcare	healthcare	NOUN
dti-1305	28	28	infrastructures	infrastructure	NOUN
dti-1305	28	29	have	have	VERB
dti-1305	28	30	yet	yet	ADV
dti-1305	28	31	to	to	PART
dti-1305	28	32	be	be	AUX
dti-1305	28	33	developed	develop	VERB
dti-1305	28	34	.	.	PUNCT
dti-1305	29	1	approved	approve	VERB
dti-1305	29	2	chemotherapies	chemotherapy	NOUN
dti-1305	29	3	that	that	PRON
dti-1305	29	4	are	be	AUX
dti-1305	29	5	available	available	ADJ
dti-1305	29	6	were	be	AUX
dti-1305	29	7	developed	develop	VERB
dti-1305	29	8	in	in	ADP
dti-1305	29	9	the	the	DET
dti-1305	29	10	fi	fi	NOUN
dti-1305	29	11	rst	rst	NOUN
dti-1305	29	12	half	half	NOUN
dti-1305	29	13	of	of	ADP
dti-1305	29	14	the	the	DET
dti-1305	29	15	last	last	ADJ
dti-1305	29	16	century	century	NOUN
dti-1305	29	17	(	(	PUNCT
dti-1305	29	18	suramine	suramine	NOUN
dti-1305	29	19	,	,	PUNCT
dti-1305	29	20	pentamidine	pentamidine	NOUN
dti-1305	29	21	,	,	PUNCT
dti-1305	29	22	arsenicals	arsenical	NOUN
dti-1305	29	23	and	and	CCONJ
dti-1305	29	24	antimonials	antimonial	NOUN
dti-1305	29	25	)	)	PUNCT
dti-1305	29	26	;	;	PUNCT
dti-1305	29	27	some	some	PRON
dti-1305	29	28	would	would	AUX
dti-1305	29	29	fail	fail	VERB
dti-1305	29	30	today	today	NOUN
dti-1305	29	31	’s	’s	PART
dti-1305	29	32	more	more	ADV
dti-1305	29	33	stringent	stringent	ADJ
dti-1305	29	34	standards	standard	NOUN
dti-1305	29	35	for	for	ADP
dti-1305	29	36	drug	drug	NOUN
dti-1305	29	37	safety	safety	NOUN
dti-1305	29	38	.	.	PUNCT
dti-1305	30	1	given	give	VERB
dti-1305	30	2	the	the	DET
dti-1305	30	3	initial	initial	ADJ
dti-1305	30	4	success	success	NOUN
dti-1305	30	5	of	of	ADP
dti-1305	30	6	a	a	DET
dti-1305	30	7	largely	largely	ADV
dti-1305	30	8	empirical	empirical	ADJ
dti-1305	30	9	approach	approach	NOUN
dti-1305	30	10	,	,	PUNCT
dti-1305	30	11	progress	progress	NOUN
dti-1305	30	12	in	in	ADP
dti-1305	30	13	drug	drug	NOUN
dti-1305	30	14	development	development	NOUN
dti-1305	30	15	in	in	ADP
dti-1305	30	16	recent	recent	ADJ
dti-1305	30	17	years	year	NOUN
dti-1305	30	18	has	have	AUX
dti-1305	30	19	been	be	AUX
dti-1305	30	20	poor	poor	ADJ
dti-1305	30	21	and	and	CCONJ
dti-1305	30	22	,	,	PUNCT
dti-1305	30	23	undoubtedly	undoubtedly	ADV
dti-1305	30	24	there	there	PRON
dti-1305	30	25	is	be	VERB
dti-1305	30	26	great	great	ADJ
dti-1305	30	27	need	need	NOUN
dti-1305	30	28	for	for	ADP
dti-1305	30	29	new	new	ADJ
dti-1305	30	30	less	less	ADV
dti-1305	30	31	toxic	toxic	ADJ
dti-1305	30	32	treatments	treatment	NOUN
dti-1305	30	33	for	for	ADP
dti-1305	30	34	human	human	ADJ
dti-1305	30	35	diseases	disease	NOUN
dti-1305	30	36	by	by	ADP
dti-1305	30	37	parasitic	parasitic	ADJ
dti-1305	30	38	trypanosomes	trypanosome	NOUN
dti-1305	30	39	and	and	CCONJ
dti-1305	30	40	leishmanias	leishmania	NOUN
dti-1305	30	41	.	.	PUNCT
dti-1305	31	1	in	in	ADP
dti-1305	31	2	view	view	NOUN
dti-1305	31	3	of	of	ADP
dti-1305	31	4	the	the	DET
dti-1305	31	5	economies	economy	NOUN
dti-1305	31	6	of	of	ADP
dti-1305	31	7	the	the	DET
dti-1305	31	8	third	third	ADJ
dti-1305	31	9	world	world	NOUN
dti-1305	31	10	countries	country	NOUN
dti-1305	31	11	suffering	suffer	VERB
dti-1305	31	12	most	most	ADV
dti-1305	31	13	from	from	ADP
dti-1305	31	14	these	these	DET
dti-1305	31	15	diseases	disease	NOUN
dti-1305	31	16	,	,	PUNCT
dti-1305	31	17	such	such	ADJ
dti-1305	31	18	drugs	drug	NOUN
dti-1305	31	19	will	will	AUX
dti-1305	31	20	have	have	VERB
dti-1305	31	21	to	to	PART
dti-1305	31	22	be	be	AUX
dti-1305	31	23	cheap	cheap	ADJ
dti-1305	31	24	and	and	CCONJ
dti-1305	31	25	simple	simple	ADJ
dti-1305	31	26	to	to	ADP
dti-1305	31	27	administer	administer	NOUN
dti-1305	31	28	.	.	PUNCT
dti-1305	32	1	so3	so3	PROPN
dti-1305	32	2	h	h	PROPN
dti-1305	32	3	n	n	PROPN
dti-1305	32	4	ch3	ch3	PROPN
dti-1305	32	5	h	h	PROPN
dti-1305	32	6	n	n	CCONJ
dti-1305	32	7	n	n	NOUN
dti-1305	32	8	h	h	NOUN
dti-1305	32	9	o	o	ADJ
dti-1305	32	10	-	-	NOUN
dti-1305	32	11	o3s	o3s	ADJ
dti-1305	32	12	so3	so3	NOUN
dti-1305	32	13	o	o	NOUN
dti-1305	32	14	o	o	NOUN
dti-1305	32	15	21	21	NUM
dti-1305	33	1	+	+	NOUN
dti-1305	33	2	h2n	h2n	NOUN
dti-1305	33	3	h2n	h2n	PROPN
dti-1305	33	4	o(ch2)5o	o(ch2)5o	PROPN
dti-1305	33	5	nh2	nh2	PROPN
dti-1305	33	6	+	+	CCONJ
dti-1305	33	7	nh2	nh2	PROPN
dti-1305	33	8	2	2	NUM
dti-1305	33	9	n	n	CCONJ
dti-1305	33	10	n	n	CCONJ
dti-1305	33	11	n	n	CCONJ
dti-1305	33	12	n	n	NOUN
dti-1305	33	13	h	h	NOUN
dti-1305	33	14	as	as	ADP
dti-1305	33	15	s	s	PROPN
dti-1305	33	16	s	s	PROPN
dti-1305	33	17	ch2oh	ch2oh	PROPN
dti-1305	33	18	h2n	h2n	PROPN
dti-1305	33	19	nh2	nh2	PROPN
dti-1305	33	20	3	3	NUM
dti-1305	33	21	as	as	ADP
dti-1305	33	22	o	o	NOUN
dti-1305	33	23	o	o	NOUN
dti-1305	33	24	-	-	NOUN
dti-1305	33	25	na+ho	na+ho	NOUN
dti-1305	33	26	nhch2conh2	nhch2conh2	NOUN
dti-1305	33	27	4	4	NUM
dti-1305	33	28	h2n	h2n	NOUN
dti-1305	33	29	chf2	chf2	NOUN
dti-1305	33	30	nh2	nh2	PROPN
dti-1305	33	31	cooh	cooh	VERB
dti-1305	33	32	5	5	NUM
dti-1305	33	33	o	o	NOUN
dti-1305	33	34	n	n	CCONJ
dti-1305	33	35	n	n	PROPN
dti-1305	33	36	o2n	o2n	PROPN
dti-1305	33	37	so2	so2	PROPN
dti-1305	33	38	ch3	ch3	PROPN
dti-1305	33	39	6	6	NUM
dti-1305	33	40	n	n	NOUN
dti-1305	33	41	n	n	PRON
dti-1305	33	42	ch2conhch2	ch2conhch2	NOUN
dti-1305	33	43	no2	no2	NOUN
dti-1305	33	44	7	7	NUM
dti-1305	33	45	o	o	NOUN
dti-1305	33	46	sb	sb	NOUN
dti-1305	34	1	o	o	NOUN
dti-1305	34	2	o	o	X
dti-1305	35	1	sb	sb	X
dti-1305	36	1	o	o	NOUN
dti-1305	36	2	o	o	X
dti-1305	37	1	ho	ho	INTJ
dti-1305	38	1	oh	oh	INTJ
dti-1305	38	2	ohoh	ohoh	INTJ
dti-1305	38	3	ho	ho	INTJ
dti-1305	39	1	oh	oh	INTJ
dti-1305	39	2	cooh	cooh	NOUN
dti-1305	39	3	cooh	cooh	NOUN
dti-1305	39	4	o	o	NOUN
dti-1305	39	5	o	o	NOUN
dti-1305	39	6	8	8	NUM
dti-1305	39	7	figure	figure	NOUN
dti-1305	39	8	1	1	NUM
dti-1305	39	9	.	.	PUNCT
dti-1305	40	1	structures	structure	NOUN
dti-1305	40	2	of	of	ADP
dti-1305	40	3	the	the	DET
dti-1305	40	4	currently	currently	ADV
dti-1305	40	5	available	available	ADJ
dti-1305	40	6	drugs	drug	NOUN
dti-1305	40	7	for	for	ADP
dti-1305	40	8	the	the	DET
dti-1305	40	9	treatment	treatment	NOUN
dti-1305	40	10	of	of	ADP
dti-1305	40	11	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	40	12	and	and	CCONJ
dti-1305	40	13	leishmaniasis	leishmaniasis	NOUN
dti-1305	40	14	.	.	PUNCT
dti-1305	41	1	drug	drug	NOUN
dti-1305	41	2	target	target	NOUN
dti-1305	41	3	insights	insight	NOUN
dti-1305	41	4	2007	2007	NUM
dti-1305	41	5	:	:	PUNCT
dti-1305	41	6	2	2	NUM
dti-1305	41	7	131	131	NUM
dti-1305	41	8	target	target	NOUN
dti-1305	41	9	for	for	ADP
dti-1305	41	10	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	41	11	and	and	CCONJ
dti-1305	41	12	antileishmanial	antileishmanial	ADJ
dti-1305	41	13	drug	drug	NOUN
dti-1305	41	14	design	design	NOUN
dti-1305	41	15	potential	potential	ADJ
dti-1305	41	16	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	41	17	targets	target	NOUN
dti-1305	41	18	for	for	ADP
dti-1305	41	19	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	41	20	and	and	CCONJ
dti-1305	41	21	leishmaniasis	leishmaniasis	NOUN
dti-1305	41	22	in	in	ADP
dti-1305	41	23	this	this	DET
dti-1305	41	24	genomic	genomic	NOUN
dti-1305	41	25	,	,	PUNCT
dti-1305	41	26	proteomic	proteomic	NOUN
dti-1305	41	27	,	,	PUNCT
dti-1305	41	28	and	and	CCONJ
dti-1305	41	29	bioinformatics	bioinformatics	NOUN
dti-1305	41	30	era	era	NOUN
dti-1305	41	31	of	of	ADP
dti-1305	41	32	target	target	NOUN
dti-1305	41	33	identifi	identifi	NOUN
dti-1305	41	34	cation	cation	NOUN
dti-1305	41	35	,	,	PUNCT
dti-1305	41	36	scores	score	NOUN
dti-1305	41	37	of	of	ADP
dti-1305	41	38	potential	potential	ADJ
dti-1305	41	39	targets	target	NOUN
dti-1305	41	40	for	for	ADP
dti-1305	41	41	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	41	42	and	and	CCONJ
dti-1305	41	43	antileishmanial	antileishmanial	ADJ
dti-1305	41	44	chemotherapy	chemotherapy	NOUN
dti-1305	41	45	will	will	AUX
dti-1305	41	46	be	be	AUX
dti-1305	41	47	emerging	emerge	VERB
dti-1305	41	48	.	.	PUNCT
dti-1305	42	1	in	in	ADP
dti-1305	42	2	the	the	DET
dti-1305	42	3	pregenomic	pregenomic	ADJ
dti-1305	42	4	era	era	NOUN
dti-1305	42	5	,	,	PUNCT
dti-1305	42	6	basic	basic	ADJ
dti-1305	42	7	research	research	NOUN
dti-1305	42	8	in	in	ADP
dti-1305	42	9	molecular	molecular	ADJ
dti-1305	42	10	biology	biology	NOUN
dti-1305	42	11	and	and	CCONJ
dti-1305	42	12	multidimensional	multidimensional	ADJ
dti-1305	42	13	research	research	NOUN
dti-1305	42	14	initiatives	initiative	NOUN
dti-1305	42	15	has	have	VERB
dti-1305	42	16	identifi	identifi	PROPN
dti-1305	42	17	ed	ed	NOUN
dti-1305	42	18	some	some	DET
dti-1305	42	19	biological	biological	ADJ
dti-1305	42	20	features	feature	NOUN
dti-1305	42	21	associated	associate	VERB
dti-1305	42	22	with	with	ADP
dti-1305	42	23	the	the	DET
dti-1305	42	24	development	development	NOUN
dti-1305	42	25	of	of	ADP
dti-1305	42	26	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	42	27	that	that	PRON
dti-1305	42	28	have	have	AUX
dti-1305	42	29	been	be	AUX
dti-1305	42	30	well	well	ADV
dti-1305	42	31	documented	document	VERB
dti-1305	42	32	and	and	CCONJ
dti-1305	42	33	studied	study	VERB
dti-1305	42	34	extensively	extensively	ADV
dti-1305	42	35	.	.	PUNCT
dti-1305	43	1	ergosterol	ergosterol	NOUN
dti-1305	43	2	biosynthesis	biosynthesis	NOUN
dti-1305	43	3	,	,	PUNCT
dti-1305	43	4	parasite	parasite	NOUN
dti-1305	43	5	specifi	specifi	X
dti-1305	43	6	c	c	NOUN
dti-1305	43	7	proteases	protease	NOUN
dti-1305	43	8	and	and	CCONJ
dti-1305	43	9	reductases	reductase	NOUN
dti-1305	43	10	,	,	PUNCT
dti-1305	43	11	purine	purine	NOUN
dti-1305	43	12	salvage	salvage	NOUN
dti-1305	43	13	and	and	CCONJ
dti-1305	43	14	phospholipid	phospholipid	NOUN
dti-1305	43	15	biosynthesis	biosynthesis	NOUN
dti-1305	43	16	(	(	PUNCT
dti-1305	43	17	for	for	ADP
dti-1305	43	18	review	review	NOUN
dti-1305	43	19	see	see	PROPN
dti-1305	43	20	urbina	urbina	PROPN
dti-1305	43	21	,	,	PUNCT
dti-1305	43	22	2003	2003	NUM
dti-1305	43	23	)	)	PUNCT
dti-1305	43	24	could	could	AUX
dti-1305	43	25	be	be	AUX
dti-1305	43	26	turned	turn	VERB
dti-1305	43	27	into	into	ADP
dti-1305	43	28	targets	target	NOUN
dti-1305	43	29	,	,	PUNCT
dti-1305	43	30	provided	provide	VERB
dti-1305	43	31	that	that	SCONJ
dti-1305	43	32	the	the	DET
dti-1305	43	33	following	follow	VERB
dti-1305	43	34	two	two	NUM
dti-1305	43	35	requirements	requirement	NOUN
dti-1305	43	36	can	can	AUX
dti-1305	43	37	be	be	AUX
dti-1305	43	38	met	meet	VERB
dti-1305	43	39	:	:	PUNCT
dti-1305	43	40	(	(	PUNCT
dti-1305	43	41	a	a	X
dti-1305	43	42	)	)	PUNCT
dti-1305	43	43	the	the	DET
dti-1305	43	44	target	target	NOUN
dti-1305	43	45	must	must	AUX
dti-1305	43	46	be	be	AUX
dti-1305	43	47	essential	essential	ADJ
dti-1305	43	48	for	for	ADP
dti-1305	43	49	the	the	DET
dti-1305	43	50	survival	survival	NOUN
dti-1305	43	51	of	of	ADP
dti-1305	43	52	the	the	DET
dti-1305	43	53	parasites	parasite	NOUN
dti-1305	43	54	,	,	PUNCT
dti-1305	43	55	and	and	CCONJ
dti-1305	43	56	(	(	PUNCT
dti-1305	43	57	b	b	X
dti-1305	43	58	)	)	PUNCT
dti-1305	43	59	the	the	DET
dti-1305	43	60	target	target	NOUN
dti-1305	43	61	must	must	AUX
dti-1305	43	62	be	be	AUX
dti-1305	43	63	such	such	ADJ
dti-1305	43	64	that	that	SCONJ
dti-1305	43	65	a	a	DET
dti-1305	43	66	counterpart	counterpart	NOUN
dti-1305	43	67	in	in	ADP
dti-1305	43	68	the	the	DET
dti-1305	43	69	mammalian	mammalian	ADJ
dti-1305	43	70	host	host	NOUN
dti-1305	43	71	either	either	CCONJ
dti-1305	43	72	does	do	AUX
dti-1305	43	73	not	not	PART
dti-1305	43	74	exist	exist	VERB
dti-1305	43	75	or	or	CCONJ
dti-1305	43	76	is	be	AUX
dti-1305	43	77	sufficiently	sufficiently	ADV
dti-1305	43	78	different	different	ADJ
dti-1305	43	79	to	to	PART
dti-1305	43	80	allow	allow	VERB
dti-1305	43	81	selective	selective	ADJ
dti-1305	43	82	inhibition	inhibition	NOUN
dti-1305	43	83	(	(	PUNCT
dti-1305	43	84	wang	wang	PROPN
dti-1305	43	85	,	,	PUNCT
dti-1305	43	86	1995	1995	NUM
dti-1305	43	87	)	)	PUNCT
dti-1305	43	88	.	.	PUNCT
dti-1305	44	1	the	the	DET
dti-1305	44	2	technological	technological	ADJ
dti-1305	44	3	advancements	advancement	NOUN
dti-1305	44	4	related	relate	VERB
dti-1305	44	5	to	to	ADP
dti-1305	44	6	post	post	ADJ
dti-1305	44	7	-	-	ADJ
dti-1305	44	8	target	target	NOUN
dti-1305	44	9	selection	selection	NOUN
dti-1305	44	10	are	be	AUX
dti-1305	44	11	also	also	ADV
dti-1305	44	12	important	important	ADJ
dti-1305	44	13	criteria	criterion	NOUN
dti-1305	44	14	.	.	PUNCT
dti-1305	45	1	because	because	SCONJ
dti-1305	45	2	the	the	DET
dti-1305	45	3	target	target	NOUN
dti-1305	45	4	must	must	AUX
dti-1305	45	5	be	be	AUX
dti-1305	45	6	suitable	suitable	ADJ
dti-1305	45	7	for	for	ADP
dti-1305	45	8	study	study	NOUN
dti-1305	45	9	at	at	ADP
dti-1305	45	10	the	the	DET
dti-1305	45	11	molecular	molecular	ADJ
dti-1305	45	12	level	level	NOUN
dti-1305	45	13	that	that	PRON
dti-1305	45	14	include	include	VERB
dti-1305	45	15	most	most	ADV
dti-1305	45	16	importantly	importantly	ADV
dti-1305	45	17	the	the	DET
dti-1305	45	18	high	high	ADJ
dti-1305	45	19	throughput	throughput	NOUN
dti-1305	45	20	screening	screen	VERB
dti-1305	45	21	for	for	ADP
dti-1305	45	22	which	which	PRON
dti-1305	45	23	convenient	convenient	ADJ
dti-1305	45	24	,	,	PUNCT
dti-1305	45	25	cheap	cheap	ADJ
dti-1305	45	26	and	and	CCONJ
dti-1305	45	27	sensitive	sensitive	ADJ
dti-1305	45	28	assay	assay	NOUN
dti-1305	45	29	methods	method	NOUN
dti-1305	45	30	are	be	AUX
dti-1305	45	31	highly	highly	ADV
dti-1305	45	32	desirable	desirable	ADJ
dti-1305	45	33	.	.	PUNCT
dti-1305	46	1	glycolytic	glycolytic	ADJ
dti-1305	46	2	pathway	pathway	NOUN
dti-1305	46	3	as	as	ADP
dti-1305	46	4	trypanosomal	trypanosomal	ADJ
dti-1305	46	5	cells	cell	NOUN
dti-1305	46	6	are	be	AUX
dti-1305	46	7	completely	completely	ADV
dti-1305	46	8	energetically	energetically	ADV
dti-1305	46	9	dependent	dependent	ADJ
dti-1305	46	10	on	on	ADP
dti-1305	46	11	glycolysis	glycolysis	NOUN
dti-1305	46	12	it	it	PRON
dti-1305	46	13	might	might	AUX
dti-1305	46	14	be	be	AUX
dti-1305	46	15	used	use	VERB
dti-1305	46	16	to	to	PART
dti-1305	46	17	develop	develop	VERB
dti-1305	46	18	new	new	ADJ
dti-1305	46	19	trypanocidal	trypanocidal	ADJ
dti-1305	46	20	drugs	drug	NOUN
dti-1305	46	21	(	(	PUNCT
dti-1305	46	22	michels	michels	PROPN
dti-1305	46	23	,	,	PUNCT
dti-1305	46	24	1988	1988	NUM
dti-1305	46	25	)	)	PUNCT
dti-1305	46	26	.	.	PUNCT
dti-1305	47	1	compertmentation	compertmentation	NOUN
dti-1305	47	2	of	of	ADP
dti-1305	47	3	glycolytic	glycolytic	ADJ
dti-1305	47	4	enzymes	enzyme	NOUN
dti-1305	47	5	is	be	AUX
dti-1305	47	6	generally	generally	ADV
dti-1305	47	7	assumed	assume	VERB
dti-1305	47	8	to	to	PART
dti-1305	47	9	result	result	VERB
dti-1305	47	10	in	in	ADP
dti-1305	47	11	an	an	DET
dti-1305	47	12	enhancement	enhancement	NOUN
dti-1305	47	13	of	of	ADP
dti-1305	47	14	the	the	DET
dti-1305	47	15	rate	rate	NOUN
dti-1305	47	16	of	of	ADP
dti-1305	47	17	glycolysis	glycolysis	NOUN
dti-1305	47	18	in	in	ADP
dti-1305	47	19	bloodstream	bloodstream	NOUN
dti-1305	47	20	trypanosomes	trypanosome	NOUN
dti-1305	47	21	,	,	PUNCT
dti-1305	47	22	approximately	approximately	ADV
dti-1305	47	23	50	50	NUM
dti-1305	47	24	-	-	PUNCT
dti-1305	47	25	times	time	NOUN
dti-1305	47	26	higher	high	ADJ
dti-1305	47	27	than	than	ADP
dti-1305	47	28	that	that	PRON
dti-1305	47	29	in	in	ADP
dti-1305	47	30	mammalian	mammalian	ADJ
dti-1305	47	31	cells	cell	NOUN
dti-1305	47	32	(	(	PUNCT
dti-1305	47	33	brohn	brohn	ADJ
dti-1305	47	34	and	and	CCONJ
dti-1305	47	35	clarkson	clarkson	PROPN
dti-1305	47	36	,	,	PUNCT
dti-1305	47	37	1980	1980	NUM
dti-1305	47	38	)	)	PUNCT
dti-1305	47	39	.	.	PUNCT
dti-1305	48	1	this	this	PRON
dti-1305	48	2	appears	appear	VERB
dti-1305	48	3	to	to	PART
dti-1305	48	4	be	be	AUX
dti-1305	48	5	necessary	necessary	ADJ
dti-1305	48	6	to	to	PART
dti-1305	48	7	compensate	compensate	VERB
dti-1305	48	8	for	for	ADP
dti-1305	48	9	poor	poor	ADJ
dti-1305	48	10	yields	yield	NOUN
dti-1305	48	11	of	of	ADP
dti-1305	48	12	energy	energy	NOUN
dti-1305	48	13	.	.	PUNCT
dti-1305	49	1	trypanosomes	trypanosome	NOUN
dti-1305	49	2	need	need	VERB
dti-1305	49	3	to	to	PART
dti-1305	49	4	replicate	replicate	VERB
dti-1305	49	5	every	every	DET
dti-1305	49	6	6	6	NUM
dti-1305	49	7	to	to	PART
dti-1305	49	8	8	8	NUM
dti-1305	49	9	h	h	NOUN
dti-1305	49	10	in	in	ADP
dti-1305	49	11	mammalian	mammalian	ADJ
dti-1305	49	12	blood	blood	NOUN
dti-1305	49	13	and	and	CCONJ
dti-1305	49	14	varian	varian	PROPN
dti-1305	49	15	surface	surface	PROPN
dti-1305	49	16	glycoproteins	glycoprotein	NOUN
dti-1305	49	17	(	(	PUNCT
dti-1305	49	18	vsgs	vsg	NOUN
dti-1305	49	19	)	)	PUNCT
dti-1305	49	20	must	must	AUX
dti-1305	49	21	be	be	AUX
dti-1305	49	22	replaced	replace	VERB
dti-1305	49	23	frequently	frequently	ADV
dti-1305	49	24	to	to	PART
dti-1305	49	25	evade	evade	VERB
dti-1305	49	26	a	a	DET
dti-1305	49	27	host	host	NOUN
dti-1305	49	28	immune	immune	ADJ
dti-1305	49	29	response	response	NOUN
dti-1305	49	30	(	(	PUNCT
dti-1305	49	31	donelson	donelson	PROPN
dti-1305	49	32	and	and	CCONJ
dti-1305	49	33	rice	rice	NOUN
dti-1305	49	34	-	-	PUNCT
dti-1305	49	35	ficht	ficht	NOUN
dti-1305	49	36	,	,	PUNCT
dti-1305	49	37	1985	1985	NUM
dti-1305	49	38	)	)	PUNCT
dti-1305	49	39	.	.	PUNCT
dti-1305	50	1	thus	thus	ADV
dti-1305	50	2	it	it	PRON
dti-1305	50	3	has	have	AUX
dti-1305	50	4	been	be	AUX
dti-1305	50	5	suggested	suggest	VERB
dti-1305	50	6	that	that	SCONJ
dti-1305	50	7	inhibition	inhibition	NOUN
dti-1305	50	8	of	of	ADP
dti-1305	50	9	any	any	DET
dti-1305	50	10	one	one	NUM
dti-1305	50	11	of	of	ADP
dti-1305	50	12	the	the	DET
dti-1305	50	13	glycolytic	glycolytic	ADJ
dti-1305	50	14	enzymes	enzyme	NOUN
dti-1305	50	15	inside	inside	ADP
dti-1305	50	16	the	the	DET
dti-1305	50	17	glycosomes	glycosome	NOUN
dti-1305	50	18	may	may	AUX
dti-1305	50	19	block	block	VERB
dti-1305	50	20	glycolytic	glycolytic	ADJ
dti-1305	50	21	activity	activity	NOUN
dti-1305	50	22	and	and	CCONJ
dti-1305	50	23	kill	kill	VERB
dti-1305	50	24	bloodstream	bloodstream	NOUN
dti-1305	50	25	trypanosomes	trypanosome	NOUN
dti-1305	50	26	(	(	PUNCT
dti-1305	50	27	clarkson	clarkson	NOUN
dti-1305	50	28	and	and	CCONJ
dti-1305	50	29	brohn	brohn	ADJ
dti-1305	50	30	,	,	PUNCT
dti-1305	50	31	1976	1976	NUM
dti-1305	50	32	;	;	PUNCT
dti-1305	50	33	michels	michel	NOUN
dti-1305	50	34	,	,	PUNCT
dti-1305	50	35	1988	1988	NUM
dti-1305	50	36	)	)	PUNCT
dti-1305	50	37	.	.	PUNCT
dti-1305	51	1	the	the	DET
dti-1305	51	2	three	three	NUM
dti-1305	51	3	dimensional	dimensional	ADJ
dti-1305	51	4	(	(	PUNCT
dti-1305	51	5	3d	3d	NOUN
dti-1305	51	6	)	)	PUNCT
dti-1305	51	7	structure	structure	NOUN
dti-1305	51	8	of	of	ADP
dti-1305	51	9	t.	t.	PROPN
dti-1305	51	10	brucei	brucei	PROPN
dti-1305	51	11	glycosomal	glycosomal	PROPN
dti-1305	51	12	triosephosphate	triosephosphate	ADJ
dti-1305	51	13	isomerase	isomerase	NOUN
dti-1305	51	14	(	(	PUNCT
dti-1305	51	15	tim	tim	PROPN
dti-1305	51	16	)	)	PUNCT
dti-1305	51	17	,	,	PUNCT
dti-1305	51	18	determined	determine	VERB
dti-1305	51	19	at	at	ADP
dti-1305	51	20	2.4	2.4	NUM
dti-1305	51	21	å	å	NOUN
dti-1305	51	22	resolution	resolution	NOUN
dti-1305	51	23	,	,	PUNCT
dti-1305	51	24	was	be	AUX
dti-1305	51	25	found	find	VERB
dti-1305	51	26	to	to	PART
dti-1305	51	27	be	be	AUX
dti-1305	51	28	very	very	ADV
dti-1305	51	29	similar	similar	ADJ
dti-1305	51	30	to	to	ADP
dti-1305	51	31	that	that	PRON
dti-1305	51	32	of	of	ADP
dti-1305	51	33	mammalian	mammalian	NOUN
dti-1305	51	34	tim	tim	PROPN
dti-1305	51	35	(	(	PUNCT
dti-1305	51	36	wierenga	wierenga	PROPN
dti-1305	51	37	et	et	PROPN
dti-1305	51	38	al	al	PROPN
dti-1305	51	39	.	.	PROPN
dti-1305	51	40	1987	1987	NUM
dti-1305	51	41	)	)	PUNCT
dti-1305	51	42	.	.	PUNCT
dti-1305	52	1	the	the	DET
dti-1305	52	2	3d	3d	NUM
dti-1305	52	3	structure	structure	NOUN
dti-1305	52	4	of	of	ADP
dti-1305	52	5	glycosomal	glycosomal	ADJ
dti-1305	52	6	glyceraldehyde-3	glyceraldehyde-3	VERB
dti-1305	52	7	-	-	ADJ
dti-1305	52	8	phosphate	phosphate	ADJ
dti-1305	52	9	dehydrogenase	dehydrogenase	NOUN
dti-1305	52	10	(	(	PUNCT
dti-1305	52	11	gadph	gadph	PROPN
dti-1305	52	12	)	)	PUNCT
dti-1305	52	13	(	(	PUNCT
dti-1305	52	14	vellieux	vellieux	X
dti-1305	52	15	et	et	PROPN
dti-1305	52	16	al	al	PROPN
dti-1305	52	17	.	.	PROPN
dti-1305	52	18	1993	1993	NUM
dti-1305	52	19	)	)	PUNCT
dti-1305	52	20	could	could	AUX
dti-1305	52	21	provide	provide	VERB
dti-1305	52	22	opportunities	opportunity	NOUN
dti-1305	52	23	for	for	ADP
dti-1305	52	24	designing	design	VERB
dti-1305	52	25	selective	selective	ADJ
dti-1305	52	26	inhibitors	inhibitor	NOUN
dti-1305	52	27	as	as	SCONJ
dti-1305	52	28	it	it	PRON
dti-1305	52	29	differs	differ	VERB
dti-1305	52	30	from	from	ADP
dti-1305	52	31	the	the	DET
dti-1305	52	32	mammalian	mammalian	ADJ
dti-1305	52	33	homolog	homolog	NOUN
dti-1305	52	34	(	(	PUNCT
dti-1305	52	35	verlinde	verlinde	NOUN
dti-1305	52	36	et	et	PROPN
dti-1305	52	37	al	al	PROPN
dti-1305	52	38	.	.	PROPN
dti-1305	52	39	1994	1994	NUM
dti-1305	52	40	;	;	PUNCT
dti-1305	52	41	wang	wang	PROPN
dti-1305	52	42	,	,	PUNCT
dti-1305	52	43	1995	1995	NUM
dti-1305	52	44	)	)	PUNCT
dti-1305	52	45	.	.	PUNCT
dti-1305	53	1	bloodstream	bloodstream	PROPN
dti-1305	53	2	t.	t.	PROPN
dti-1305	53	3	b.	b.	PROPN
dti-1305	53	4	brucei	brucei	PROPN
dti-1305	53	5	imports	import	NOUN
dti-1305	53	6	glucose	glucose	NOUN
dti-1305	53	7	by	by	ADP
dti-1305	53	8	facilitated	facilitated	ADJ
dti-1305	53	9	diffusion	diffusion	NOUN
dti-1305	53	10	and	and	CCONJ
dti-1305	53	11	the	the	DET
dti-1305	53	12	uptake	uptake	NOUN
dti-1305	53	13	of	of	ADP
dti-1305	53	14	glucose	glucose	NOUN
dti-1305	53	15	apparently	apparently	ADV
dti-1305	53	16	represents	represent	VERB
dti-1305	53	17	the	the	DET
dti-1305	53	18	rate	rate	NOUN
dti-1305	53	19	-	-	PUNCT
dti-1305	53	20	limiting	limit	VERB
dti-1305	53	21	step	step	NOUN
dti-1305	53	22	in	in	ADP
dti-1305	53	23	glycolysis	glycolysis	NOUN
dti-1305	53	24	.	.	PUNCT
dti-1305	54	1	the	the	DET
dti-1305	54	2	genes	gene	NOUN
dti-1305	54	3	encoding	encode	VERB
dti-1305	54	4	trypanosomal	trypanosomal	ADJ
dti-1305	54	5	glucose	glucose	NOUN
dti-1305	54	6	transporters	transporter	NOUN
dti-1305	54	7	are	be	AUX
dti-1305	54	8	tandemly	tandemly	ADV
dti-1305	54	9	arranged	arrange	VERB
dti-1305	54	10	in	in	ADP
dti-1305	54	11	a	a	DET
dti-1305	54	12	multigene	multigene	ADJ
dti-1305	54	13	family	family	NOUN
dti-1305	54	14	consisting	consist	VERB
dti-1305	54	15	of	of	ADP
dti-1305	54	16	two	two	NUM
dti-1305	54	17	homologous	homologous	ADJ
dti-1305	54	18	groups	group	NOUN
dti-1305	54	19	,	,	PUNCT
dti-1305	54	20	trypanosome	trypanosome	NOUN
dti-1305	54	21	hexos	hexos	NOUN
dti-1305	54	22	transporter	transporter	NOUN
dti-1305	54	23	(	(	PUNCT
dti-1305	54	24	tht)1	tht)1	PROPN
dti-1305	54	25	and	and	CCONJ
dti-1305	54	26	tht2	tht2	PROPN
dti-1305	54	27	.	.	PUNCT
dti-1305	55	1	tht1	tht1	PROPN
dti-1305	55	2	-	-	PUNCT
dti-1305	55	3	encoded	encode	VERB
dti-1305	55	4	glucose	glucose	NOUN
dti-1305	55	5	transporters	transporter	NOUN
dti-1305	55	6	,	,	PUNCT
dti-1305	55	7	preferentially	preferentially	ADV
dti-1305	55	8	expressed	express	VERB
dti-1305	55	9	in	in	ADP
dti-1305	55	10	a	a	DET
dti-1305	55	11	bloodstream	bloodstream	NOUN
dti-1305	55	12	form	form	NOUN
dti-1305	55	13	,	,	PUNCT
dti-1305	55	14	have	have	VERB
dti-1305	55	15	a	a	DET
dti-1305	55	16	moderate	moderate	ADJ
dti-1305	55	17	sensitivity	sensitivity	NOUN
dti-1305	55	18	to	to	ADP
dti-1305	55	19	cytochalasin	cytochalasin	PROPN
dti-1305	55	20	b	b	PROPN
dti-1305	55	21	and	and	CCONJ
dti-1305	55	22	recognize	recognize	VERB
dti-1305	55	23	d	d	NOUN
dti-1305	55	24	-	-	PUNCT
dti-1305	55	25	fructose	fructose	NOUN
dti-1305	55	26	as	as	ADP
dti-1305	55	27	substrate	substrate	NOUN
dti-1305	55	28	,	,	PUNCT
dti-1305	55	29	thereby	thereby	ADV
dti-1305	55	30	distinguishing	distinguish	VERB
dti-1305	55	31	them	they	PRON
dti-1305	55	32	from	from	ADP
dti-1305	55	33	the	the	DET
dti-1305	55	34	human	human	ADJ
dti-1305	55	35	erythrocyte	erythrocyte	NOUN
dti-1305	55	36	glucose	glucose	NOUN
dti-1305	55	37	transporter	transporter	NOUN
dti-1305	55	38	.	.	PUNCT
dti-1305	56	1	they	they	PRON
dti-1305	56	2	are	be	AUX
dti-1305	56	3	potential	potential	ADJ
dti-1305	56	4	targets	target	NOUN
dti-1305	56	5	for	for	ADP
dti-1305	56	6	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	56	7	chemotherapy	chemotherapy	NOUN
dti-1305	56	8	(	(	PUNCT
dti-1305	56	9	for	for	ADP
dti-1305	56	10	review	review	NOUN
dti-1305	56	11	,	,	PUNCT
dti-1305	56	12	see	see	VERB
dti-1305	56	13	wang	wang	PROPN
dti-1305	56	14	,	,	PUNCT
dti-1305	56	15	1995	1995	NUM
dti-1305	56	16	)	)	PUNCT
dti-1305	56	17	.	.	PUNCT
dti-1305	57	1	dna	dna	PROPN
dti-1305	57	2	topoisomerases	topoisomerase	VERB
dti-1305	57	3	many	many	ADJ
dti-1305	57	4	of	of	ADP
dti-1305	57	5	the	the	DET
dti-1305	57	6	established	establish	VERB
dti-1305	57	7	antiprotozoal	antiprotozoal	NOUN
dti-1305	57	8	agents	agent	NOUN
dti-1305	57	9	are	be	AUX
dti-1305	57	10	known	know	VERB
dti-1305	57	11	to	to	PART
dti-1305	57	12	bind	bind	VERB
dti-1305	57	13	to	to	ADP
dti-1305	57	14	dna	dna	PROPN
dti-1305	57	15	.	.	PUNCT
dti-1305	58	1	there	there	PRON
dti-1305	58	2	are	be	VERB
dti-1305	58	3	two	two	NUM
dti-1305	58	4	potential	potential	ADJ
dti-1305	58	5	sites	site	NOUN
dti-1305	58	6	for	for	ADP
dti-1305	58	7	dna	dna	NOUN
dti-1305	58	8	binding	bind	VERB
dti-1305	58	9	in	in	ADP
dti-1305	58	10	members	member	NOUN
dti-1305	58	11	of	of	ADP
dti-1305	58	12	the	the	DET
dti-1305	58	13	kinetoplastida	kinetoplastida	NOUN
dti-1305	58	14	:	:	PUNCT
dti-1305	58	15	nuclear	nuclear	ADJ
dti-1305	58	16	and	and	CCONJ
dti-1305	58	17	kinetoplast	kinetoplast	ADJ
dti-1305	58	18	dna	dna	PROPN
dti-1305	58	19	.	.	PUNCT
dti-1305	59	1	in	in	ADP
dti-1305	59	2	general	general	ADJ
dti-1305	59	3	,	,	PUNCT
dti-1305	59	4	dna	dna	NOUN
dti-1305	59	5	binding	bind	VERB
dti-1305	59	6	agents	agent	NOUN
dti-1305	59	7	would	would	AUX
dti-1305	59	8	be	be	AUX
dti-1305	59	9	expected	expect	VERB
dti-1305	59	10	to	to	PART
dti-1305	59	11	be	be	AUX
dti-1305	59	12	active	active	ADJ
dti-1305	59	13	against	against	ADP
dti-1305	59	14	protozoa	protozoan	NOUN
dti-1305	59	15	,	,	PUNCT
dti-1305	59	16	but	but	CCONJ
dti-1305	59	17	toxicity	toxicity	NOUN
dti-1305	59	18	is	be	AUX
dti-1305	59	19	a	a	DET
dti-1305	59	20	major	major	ADJ
dti-1305	59	21	factor	factor	NOUN
dti-1305	59	22	.	.	PUNCT
dti-1305	60	1	it	it	PRON
dti-1305	60	2	was	be	AUX
dti-1305	60	3	assumed	assume	VERB
dti-1305	60	4	that	that	SCONJ
dti-1305	60	5	binding	bind	VERB
dti-1305	60	6	to	to	ADP
dti-1305	60	7	dna	dna	PROPN
dti-1305	60	8	leads	lead	VERB
dti-1305	60	9	directly	directly	ADV
dti-1305	60	10	to	to	ADP
dti-1305	60	11	inhibition	inhibition	NOUN
dti-1305	60	12	of	of	ADP
dti-1305	60	13	dna	dna	NOUN
dti-1305	60	14	-	-	PUNCT
dti-1305	60	15	dependent	dependent	ADJ
dti-1305	60	16	processes	process	NOUN
dti-1305	60	17	,	,	PUNCT
dti-1305	60	18	but	but	CCONJ
dti-1305	60	19	it	it	PRON
dti-1305	60	20	is	be	AUX
dti-1305	60	21	now	now	ADV
dti-1305	60	22	generally	generally	ADV
dti-1305	60	23	accepted	accept	VERB
dti-1305	60	24	that	that	SCONJ
dti-1305	60	25	intercalating	intercalate	VERB
dti-1305	60	26	agents	agent	NOUN
dti-1305	60	27	induce	induce	VERB
dti-1305	60	28	topoisomerase	topoisomerase	PROPN
dti-1305	60	29	ii	ii	PROPN
dti-1305	60	30	–	–	PUNCT
dti-1305	60	31	mediated	mediate	VERB
dti-1305	60	32	strand	strand	NOUN
dti-1305	60	33	breaks	break	NOUN
dti-1305	60	34	in	in	ADP
dti-1305	60	35	dna	dna	PROPN
dti-1305	60	36	(	(	PUNCT
dti-1305	60	37	brown	brown	ADJ
dti-1305	60	38	,	,	PUNCT
dti-1305	60	39	1987	1987	NUM
dti-1305	60	40	)	)	PUNCT
dti-1305	60	41	.	.	PUNCT
dti-1305	61	1	trypanosomal	trypanosomal	ADJ
dti-1305	61	2	topoisomerase	topoisomerase	PROPN
dti-1305	61	3	ii	ii	PROPN
dti-1305	61	4	inhibitors	inhibitor	NOUN
dti-1305	61	5	affect	affect	VERB
dti-1305	61	6	both	both	CCONJ
dti-1305	61	7	nuclear	nuclear	ADJ
dti-1305	61	8	and	and	CCONJ
dti-1305	61	9	mitochondrial	mitochondrial	ADJ
dti-1305	61	10	dna	dna	NOUN
dti-1305	61	11	and	and	CCONJ
dti-1305	61	12	may	may	AUX
dti-1305	61	13	prove	prove	VERB
dti-1305	61	14	to	to	PART
dti-1305	61	15	be	be	AUX
dti-1305	61	16	effective	effective	ADJ
dti-1305	61	17	and	and	CCONJ
dti-1305	61	18	safe	safe	ADJ
dti-1305	61	19	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	61	20	drugs	drug	NOUN
dti-1305	61	21	(	(	PUNCT
dti-1305	61	22	shapiro	shapiro	NOUN
dti-1305	61	23	,	,	PUNCT
dti-1305	61	24	1993	1993	NUM
dti-1305	61	25	)	)	PUNCT
dti-1305	61	26	as	as	SCONJ
dti-1305	61	27	they	they	PRON
dti-1305	61	28	differ	differ	VERB
dti-1305	61	29	structurally	structurally	ADV
dti-1305	61	30	from	from	ADP
dti-1305	61	31	mammalian	mammalian	ADJ
dti-1305	61	32	topoisomerase	topoisomerase	PROPN
dti-1305	61	33	ii	ii	PROPN
dti-1305	61	34	(	(	PUNCT
dti-1305	61	35	shapiro	shapiro	PROPN
dti-1305	61	36	and	and	CCONJ
dti-1305	61	37	showalter	showalter	PROPN
dti-1305	61	38	,	,	PUNCT
dti-1305	61	39	1994	1994	NUM
dti-1305	61	40	)	)	PUNCT
dti-1305	61	41	.	.	PUNCT
dti-1305	62	1	dna	dna	PROPN
dti-1305	62	2	topoisomerase	topoisomerase	NOUN
dti-1305	62	3	i	i	PRON
dti-1305	62	4	could	could	AUX
dti-1305	62	5	also	also	ADV
dti-1305	62	6	serve	serve	VERB
dti-1305	62	7	as	as	ADP
dti-1305	62	8	an	an	DET
dti-1305	62	9	intracellular	intracellular	ADJ
dti-1305	62	10	target	target	NOUN
dti-1305	62	11	,	,	PUNCT
dti-1305	62	12	as	as	SCONJ
dti-1305	62	13	its	its	PRON
dti-1305	62	14	inhibition	inhibition	NOUN
dti-1305	62	15	can	can	AUX
dti-1305	62	16	cause	cause	VERB
dti-1305	62	17	dna	dna	NOUN
dti-1305	62	18	-	-	PUNCT
dti-1305	62	19	cleavage	cleavage	NOUN
dti-1305	62	20	and	and	CCONJ
dti-1305	62	21	ultimate	ultimate	ADJ
dti-1305	62	22	death	death	NOUN
dti-1305	62	23	of	of	ADP
dti-1305	62	24	trypanosomes	trypanosome	NOUN
dti-1305	62	25	(	(	PUNCT
dti-1305	62	26	bodley	bodley	NOUN
dti-1305	62	27	et	et	PROPN
dti-1305	62	28	al	al	PROPN
dti-1305	62	29	.	.	PROPN
dti-1305	62	30	1995	1995	NUM
dti-1305	62	31	)	)	PUNCT
dti-1305	62	32	.	.	PUNCT
dti-1305	63	1	ergosterol	ergosterol	NOUN
dti-1305	63	2	biosynthesis	biosynthesis	NOUN
dti-1305	63	3	ergosterol	ergosterol	NOUN
dti-1305	63	4	biosynthesis	biosynthesis	NOUN
dti-1305	63	5	is	be	AUX
dti-1305	63	6	a	a	DET
dti-1305	63	7	novel	novel	ADJ
dti-1305	63	8	metabolic	metabolic	NOUN
dti-1305	63	9	pathway	pathway	NOUN
dti-1305	63	10	essential	essential	ADJ
dti-1305	63	11	for	for	ADP
dti-1305	63	12	parasitic	parasitic	ADJ
dti-1305	63	13	survival	survival	NOUN
dti-1305	63	14	lacking	lack	VERB
dti-1305	63	15	a	a	DET
dti-1305	63	16	counterpart	counterpart	NOUN
dti-1305	63	17	in	in	ADP
dti-1305	63	18	the	the	DET
dti-1305	63	19	host	host	NOUN
dti-1305	63	20	.	.	PUNCT
dti-1305	64	1	several	several	ADJ
dti-1305	64	2	enzymes	enzyme	NOUN
dti-1305	64	3	of	of	ADP
dti-1305	64	4	this	this	DET
dti-1305	64	5	pathway	pathway	NOUN
dti-1305	64	6	,	,	PUNCT
dti-1305	64	7	e.g.	e.g.	ADV
dti-1305	64	8	squalene	squalene	NOUN
dti-1305	64	9	synthase	synthase	NOUN
dti-1305	64	10	,	,	PUNCT
dti-1305	64	11	fernesylpyrophosphate	fernesylpyrophosphate	ADJ
dti-1305	64	12	synthase	synthase	NOUN
dti-1305	64	13	are	be	AUX
dti-1305	64	14	capable	capable	ADJ
dti-1305	64	15	of	of	ADP
dti-1305	64	16	depleting	deplete	VERB
dti-1305	64	17	drug	drug	NOUN
dti-1305	64	18	target	target	NOUN
dti-1305	64	19	insights	insight	NOUN
dti-1305	64	20	2007	2007	NUM
dti-1305	64	21	:	:	PUNCT
dti-1305	64	22	2	2	NUM
dti-1305	64	23	132	132	NUM
dti-1305	64	24	khan	khan	NOUN
dti-1305	64	25	as	as	SCONJ
dti-1305	64	26	shown	show	VERB
dti-1305	64	27	in	in	ADP
dti-1305	64	28	figure	figure	NOUN
dti-1305	64	29	2	2	NUM
dti-1305	64	30	,	,	PUNCT
dti-1305	64	31	ornithine	ornithine	ADJ
dti-1305	64	32	decarboxylase	decarboxylase	NOUN
dti-1305	64	33	(	(	PUNCT
dti-1305	64	34	odc	odc	PROPN
dti-1305	64	35	)	)	PUNCT
dti-1305	64	36	,	,	PUNCT
dti-1305	64	37	s	s	X
dti-1305	64	38	-	-	PUNCT
dti-1305	64	39	adenosyl	adenosyl	ADJ
dti-1305	64	40	-	-	PUNCT
dti-1305	64	41	l	l	NOUN
dti-1305	64	42	-	-	PUNCT
dti-1305	64	43	methionine	methionine	NOUN
dti-1305	64	44	decarboxylase	decarboxylase	NOUN
dti-1305	64	45	(	(	PUNCT
dti-1305	64	46	samdc	samdc	NOUN
dti-1305	64	47	)	)	PUNCT
dti-1305	64	48	and	and	CCONJ
dti-1305	64	49	spermidine	spermidine	VERB
dti-1305	64	50	synthetase	synthetase	NOUN
dti-1305	64	51	in	in	ADP
dti-1305	64	52	trypanosomes	trypanosome	NOUN
dti-1305	64	53	serve	serve	VERB
dti-1305	64	54	crucial	crucial	ADJ
dti-1305	64	55	functions	function	NOUN
dti-1305	64	56	(	(	PUNCT
dti-1305	64	57	fairlamb	fairlamb	NOUN
dti-1305	64	58	and	and	CCONJ
dti-1305	64	59	bowman	bowman	NOUN
dti-1305	64	60	,	,	PUNCT
dti-1305	64	61	1980	1980	NUM
dti-1305	64	62	)	)	PUNCT
dti-1305	64	63	and	and	CCONJ
dti-1305	64	64	may	may	AUX
dti-1305	64	65	be	be	AUX
dti-1305	64	66	potential	potential	ADJ
dti-1305	64	67	targets	target	NOUN
dti-1305	64	68	for	for	ADP
dti-1305	64	69	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	64	70	chemotherapy	chemotherapy	NOUN
dti-1305	64	71	.	.	PUNCT
dti-1305	65	1	little	little	ADJ
dti-1305	65	2	is	be	AUX
dti-1305	65	3	known	know	VERB
dti-1305	65	4	about	about	ADP
dti-1305	65	5	trypanosomal	trypanosomal	ADJ
dti-1305	65	6	samdc	samdc	NOUN
dti-1305	65	7	except	except	SCONJ
dti-1305	65	8	that	that	SCONJ
dti-1305	65	9	it	it	PRON
dti-1305	65	10	did	do	AUX
dti-1305	65	11	not	not	PART
dti-1305	65	12	cross	cross	VERB
dti-1305	65	13	-	-	VERB
dti-1305	65	14	react	react	ADJ
dti-1305	65	15	with	with	ADP
dti-1305	65	16	human	human	ADJ
dti-1305	65	17	samdc	samdc	NOUN
dti-1305	65	18	antiserum	antiserum	NOUN
dti-1305	65	19	(	(	PUNCT
dti-1305	65	20	tekwani	tekwani	X
dti-1305	65	21	et	et	PROPN
dti-1305	65	22	al	al	PROPN
dti-1305	65	23	.	.	PROPN
dti-1305	65	24	1992	1992	NUM
dti-1305	65	25	)	)	PUNCT
dti-1305	65	26	.	.	PUNCT
dti-1305	66	1	detailed	detailed	ADJ
dti-1305	66	2	comparison	comparison	NOUN
dti-1305	66	3	of	of	ADP
dti-1305	66	4	mammalian	mammalian	ADJ
dti-1305	66	5	and	and	CCONJ
dti-1305	66	6	trypanosomal	trypanosomal	ADJ
dti-1305	66	7	samdcs	samdc	NOUN
dti-1305	66	8	have	have	AUX
dti-1305	66	9	not	not	PART
dti-1305	66	10	yet	yet	ADV
dti-1305	66	11	been	be	AUX
dti-1305	66	12	done	do	VERB
dti-1305	66	13	nor	nor	CCONJ
dti-1305	66	14	have	have	VERB
dti-1305	66	15	crystal	crystal	NOUN
dti-1305	66	16	structure	structure	NOUN
dti-1305	66	17	and	and	CCONJ
dti-1305	66	18	amino	amino	NOUN
dti-1305	66	19	acid	acid	NOUN
dti-1305	66	20	sequence	sequence	NOUN
dti-1305	66	21	been	be	AUX
dti-1305	66	22	determined	determine	VERB
dti-1305	66	23	,	,	PUNCT
dti-1305	66	24	steps	step	VERB
dti-1305	66	25	important	important	ADJ
dti-1305	66	26	for	for	ADP
dti-1305	66	27	designing	design	VERB
dti-1305	66	28	drugs	drug	NOUN
dti-1305	66	29	active	active	ADJ
dti-1305	66	30	against	against	ADP
dti-1305	66	31	this	this	DET
dti-1305	66	32	enzyme	enzyme	NOUN
dti-1305	66	33	.	.	PUNCT
dti-1305	67	1	trypanothione	trypanothione	NOUN
dti-1305	67	2	is	be	AUX
dti-1305	67	3	a	a	DET
dti-1305	67	4	conjugate	conjugate	NOUN
dti-1305	67	5	of	of	ADP
dti-1305	67	6	glutathione	glutathione	NOUN
dti-1305	67	7	and	and	CCONJ
dti-1305	67	8	the	the	DET
dti-1305	67	9	polyamine	polyamine	NOUN
dti-1305	67	10	spermidine	spermidine	NOUN
dti-1305	67	11	.	.	PUNCT
dti-1305	68	1	this	this	DET
dti-1305	68	2	polyamine	polyamine	NOUN
dti-1305	68	3	component	component	NOUN
dti-1305	68	4	of	of	ADP
dti-1305	68	5	the	the	DET
dti-1305	68	6	structure	structure	NOUN
dti-1305	68	7	of	of	ADP
dti-1305	68	8	trypanothione	trypanothione	PROPN
dti-1305	68	9	disulfi	disulfi	PROPN
dti-1305	68	10	de	de	X
dti-1305	68	11	(	(	PUNCT
dti-1305	68	12	t[s]2	t[s]2	NOUN
dti-1305	68	13	)	)	PUNCT
dti-1305	68	14	rationalized	rationalize	VERB
dti-1305	68	15	the	the	DET
dti-1305	68	16	actions	action	NOUN
dti-1305	68	17	of	of	ADP
dti-1305	68	18	several	several	ADJ
dti-1305	68	19	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	68	20	and	and	CCONJ
dti-1305	68	21	antileishmanial	antileishmanial	ADJ
dti-1305	68	22	drugs	drug	NOUN
dti-1305	68	23	.	.	PUNCT
dti-1305	69	1	for	for	ADP
dti-1305	69	2	example	example	NOUN
dti-1305	69	3	,	,	PUNCT
dti-1305	69	4	dfmo	dfmo	NOUN
dti-1305	69	5	(	(	PUNCT
dti-1305	69	6	5	5	NUM
dti-1305	69	7	)	)	PUNCT
dti-1305	69	8	,	,	PUNCT
dti-1305	69	9	the	the	DET
dti-1305	69	10	fi	fi	NOUN
dti-1305	69	11	rst	rst	PROPN
dti-1305	69	12	new	new	ADJ
dti-1305	69	13	drug	drug	NOUN
dti-1305	69	14	licensed	license	VERB
dti-1305	69	15	to	to	PART
dti-1305	69	16	treat	treat	VERB
dti-1305	69	17	hat	hat	NOUN
dti-1305	69	18	for	for	ADP
dti-1305	69	19	over	over	ADP
dti-1305	69	20	50	50	NUM
dti-1305	69	21	years	year	NOUN
dti-1305	69	22	,	,	PUNCT
dti-1305	69	23	inhibits	inhibit	VERB
dti-1305	69	24	odc	odc	PROPN
dti-1305	69	25	,	,	PUNCT
dti-1305	69	26	which	which	PRON
dti-1305	69	27	catalyzes	catalyze	VERB
dti-1305	69	28	the	the	DET
dti-1305	69	29	initial	initial	ADJ
dti-1305	69	30	step	step	NOUN
dti-1305	69	31	in	in	ADP
dti-1305	69	32	polyamine	polyamine	NOUN
dti-1305	69	33	biosynthesis	biosynthesis	NOUN
dti-1305	69	34	(	(	PUNCT
dti-1305	69	35	fig	fig	NOUN
dti-1305	69	36	.	.	PUNCT
dti-1305	70	1	2	2	NUM
dti-1305	70	2	)	)	PUNCT
dti-1305	70	3	,	,	PUNCT
dti-1305	70	4	decreasing	decrease	VERB
dti-1305	70	5	the	the	DET
dti-1305	70	6	trypanothione	trypanothione	NOUN
dti-1305	70	7	pool	pool	NOUN
dti-1305	70	8	.	.	PUNCT
dti-1305	71	1	the	the	DET
dti-1305	71	2	origin	origin	NOUN
dti-1305	71	3	of	of	ADP
dti-1305	71	4	the	the	DET
dti-1305	71	5	trypanocidal	trypanocidal	ADJ
dti-1305	71	6	effect	effect	NOUN
dti-1305	71	7	of	of	ADP
dti-1305	71	8	dfmo	dfmo	NOUN
dti-1305	71	9	has	have	AUX
dti-1305	71	10	not	not	PART
dti-1305	71	11	been	be	AUX
dti-1305	71	12	established	establish	VERB
dti-1305	71	13	(	(	PUNCT
dti-1305	71	14	fairlamb	fairlamb	NOUN
dti-1305	71	15	and	and	CCONJ
dti-1305	71	16	cerami	cerami	NOUN
dti-1305	71	17	,	,	PUNCT
dti-1305	71	18	1992	1992	NUM
dti-1305	71	19	)	)	PUNCT
dti-1305	71	20	.	.	PUNCT
dti-1305	72	1	figure	figure	NOUN
dti-1305	72	2	2	2	NUM
dti-1305	72	3	.	.	PUNCT
dti-1305	72	4	metabolism	metabolism	NOUN
dti-1305	72	5	and	and	CCONJ
dti-1305	72	6	function	function	NOUN
dti-1305	72	7	of	of	ADP
dti-1305	72	8	trypanothione	trypanothione	NOUN
dti-1305	72	9	,	,	PUNCT
dti-1305	72	10	showing	show	VERB
dti-1305	72	11	possible	possible	ADJ
dti-1305	72	12	sites	site	NOUN
dti-1305	72	13	of	of	ADP
dti-1305	72	14	action	action	NOUN
dti-1305	72	15	of	of	ADP
dti-1305	72	16	trypanocidal	trypanocidal	NOUN
dti-1305	72	17	compounds	compound	NOUN
dti-1305	72	18	.	.	PUNCT
dti-1305	73	1	the	the	DET
dti-1305	73	2	insert	insert	NOUN
dti-1305	73	3	above	above	ADV
dti-1305	73	4	illustrates	illustrate	VERB
dti-1305	73	5	the	the	DET
dti-1305	73	6	futile	futile	ADJ
dti-1305	73	7	redox	redox	ADJ
dti-1305	73	8	cycling	cycling	NOUN
dti-1305	73	9	by	by	ADP
dti-1305	73	10	nitro	nitro	NOUN
dti-1305	73	11	compounds	compound	NOUN
dti-1305	73	12	(	(	PUNCT
dti-1305	73	13	rno2	rno2	PROPN
dti-1305	73	14	)	)	PUNCT
dti-1305	73	15	to	to	PART
dti-1305	73	16	form	form	VERB
dti-1305	73	17	hydrogen	hydrogen	NOUN
dti-1305	73	18	peroxide	peroxide	NOUN
dti-1305	73	19	(	(	PUNCT
dti-1305	73	20	h2o2	h2o2	NOUN
dti-1305	73	21	)	)	PUNCT
dti-1305	73	22	and	and	CCONJ
dti-1305	73	23	hydroxyl	hydroxyl	NOUN
dti-1305	73	24	radicals	radical	NOUN
dti-1305	73	25	(	(	PUNCT
dti-1305	73	26	oh	oh	NOUN
dti-1305	73	27	●	●	NOUN
dti-1305	73	28	)	)	PUNCT
dti-1305	73	29	.	.	PUNCT
dti-1305	74	1	abbreviations	abbreviation	NOUN
dti-1305	74	2	:	:	PUNCT
dti-1305	74	3	bso	bso	PROPN
dti-1305	74	4	,	,	PUNCT
dti-1305	74	5	buthionine	buthionine	PROPN
dti-1305	74	6	sulfoximine	sulfoximine	NOUN
dti-1305	74	7	;	;	PUNCT
dti-1305	74	8	dfmo	dfmo	NOUN
dti-1305	74	9	,	,	PUNCT
dti-1305	74	10	difl	difl	NOUN
dti-1305	74	11	uoromethylornithine	uoromethylornithine	NOUN
dti-1305	74	12	;	;	PUNCT
dti-1305	74	13	r	r	X
dti-1305	74	14	-	-	PUNCT
dti-1305	74	15	as	as	ADP
dti-1305	74	16	=	=	NOUN
dti-1305	74	17	o	o	NOUN
dti-1305	74	18	,	,	PUNCT
dti-1305	74	19	melarsen	melarsen	NOUN
dti-1305	74	20	oxide	oxide	NOUN
dti-1305	74	21	;	;	PUNCT
dti-1305	74	22	mel	mel	PROPN
dti-1305	74	23	t	t	PROPN
dti-1305	74	24	,	,	PUNCT
dti-1305	74	25	melarsen	melarsen	NOUN
dti-1305	74	26	trypanothione	trypanothione	NOUN
dti-1305	74	27	adduct	adduct	NOUN
dti-1305	74	28	;	;	PUNCT
dti-1305	74	29	put	put	NOUN
dti-1305	74	30	,	,	PUNCT
dti-1305	74	31	putrescine	putrescine	NOUN
dti-1305	74	32	;	;	PUNCT
dti-1305	74	33	spd	spd	ADJ
dti-1305	74	34	,	,	PUNCT
dti-1305	74	35	spermidine	spermidine	NOUN
dti-1305	74	36	;	;	PUNCT
dti-1305	74	37	dsam	dsam	PROPN
dti-1305	74	38	,	,	PUNCT
dti-1305	74	39	decarboxylated	decarboxylate	VERB
dti-1305	74	40	s	s	NOUN
dti-1305	74	41	-	-	NOUN
dti-1305	74	42	adenosylmethionine	adenosylmethionine	NOUN
dti-1305	74	43	;	;	PUNCT
dti-1305	74	44	mta	mta	PROPN
dti-1305	74	45	,	,	PUNCT
dti-1305	74	46	methylthioadenosine	methylthioadenosine	NOUN
dti-1305	74	47	(	(	PUNCT
dti-1305	74	48	modifi	modifi	PROPN
dti-1305	74	49	ed	ed	NOUN
dti-1305	74	50	from	from	ADP
dti-1305	74	51	krauth	krauth	PROPN
dti-1305	74	52	-	-	PUNCT
dti-1305	74	53	siegel	siegel	PROPN
dti-1305	74	54	et	et	PROPN
dti-1305	74	55	al	al	PROPN
dti-1305	74	56	.	.	PROPN
dti-1305	74	57	1987	1987	NUM
dti-1305	74	58	)	)	PUNCT
dti-1305	74	59	.	.	PUNCT
dti-1305	75	1	nadph	nadph	PROPN
dti-1305	75	2	nadp+	nadp+	PROPN
dti-1305	75	3	rno2	rno2	PROPN
dti-1305	75	4	rno	rno	PROPN
dti-1305	75	5	o2	o2	PROPN
dti-1305	75	6	o2	o2	PROPN
dti-1305	75	7	o2	o2	PROPN
dti-1305	75	8	h2o2	h2o2	PROPN
dti-1305	76	1	oh	oh	INTJ
dti-1305	76	2	+	+	NUM
dti-1305	77	1	oh	oh	INTJ
dti-1305	77	2	+	+	CCONJ
dti-1305	77	3	o2	o2	ADJ
dti-1305	77	4	2h2o	2h2o	NUM
dti-1305	77	5	glu	glu	NOUN
dti-1305	77	6	+	+	CCONJ
dti-1305	77	7	cys	cys	PROPN
dti-1305	77	8	bso	bso	PROPN
dti-1305	77	9	-glu	-glu	PROPN
dti-1305	77	10	-	-	PUNCT
dti-1305	77	11	cys	cys	PROPN
dti-1305	77	12	gly	gly	PROPN
dti-1305	77	13	gsh	gsh	PROPN
dti-1305	77	14	spd	spd	PROPN
dti-1305	77	15	n1	n1	PROPN
dti-1305	77	16	-	-	PUNCT
dti-1305	77	17	gsh	gsh	NOUN
dti-1305	77	18	-	-	PUNCT
dti-1305	77	19	spd	spd	NOUN
dti-1305	77	20	n8	n8	PROPN
dti-1305	77	21	-	-	PUNCT
dti-1305	77	22	gsh	gsh	NOUN
dti-1305	77	23	-	-	PUNCT
dti-1305	77	24	spd	spd	NOUN
dti-1305	77	25	t[sh]2	t[sh]2	PROPN
dti-1305	77	26	gsh	gsh	PROPN
dti-1305	77	27	gsh	gsh	PROPN
dti-1305	77	28	t[s]2	t[s]2	PROPN
dti-1305	77	29	gssg	gssg	VERB
dti-1305	77	30	2gsh	2gsh	PROPN
dti-1305	77	31	nadphnadp+	nadphnadp+	NOUN
dti-1305	77	32	ras	ras	PROPN
dti-1305	77	33	=	=	PROPN
dti-1305	77	34	o	o	PROPN
dti-1305	77	35	mel	mel	PROPN
dti-1305	77	36	t	t	PROPN
dti-1305	77	37	rno2	rno2	PROPN
dti-1305	77	38	r	r	NOUN
dti-1305	77	39	as	as	ADP
dti-1305	77	40	s	s	PROPN
dti-1305	77	41	s	s	PROPN
dti-1305	77	42	t	t	PROPN
dti-1305	77	43	(	(	PUNCT
dti-1305	77	44	mel	mel	PROPN
dti-1305	77	45	t	t	PROPN
dti-1305	77	46	)	)	PUNCT
dti-1305	77	47	put	put	VERB
dti-1305	77	48	odc	odc	PROPN
dti-1305	77	49	co2	co2	NOUN
dti-1305	77	50	dfmo	dfmo	PROPN
dti-1305	77	51	mta	mta	PROPN
dti-1305	77	52	dsam	dsam	PROPN
dti-1305	77	53	co2	co2	NOUN
dti-1305	77	54	sam	sam	PROPN
dti-1305	77	55	met	meet	VERB
dti-1305	77	56	+	+	CCONJ
dti-1305	77	57	atppi	atppi	NOUN
dti-1305	77	58	,	,	PUNCT
dti-1305	77	59	ppi	ppi	X
dti-1305	77	60	endogenous	endogenous	ADJ
dti-1305	77	61	sterols	sterol	NOUN
dti-1305	77	62	,	,	PUNCT
dti-1305	77	63	and	and	CCONJ
dti-1305	77	64	therefore	therefore	ADV
dti-1305	77	65	represent	represent	VERB
dti-1305	77	66	viable	viable	ADJ
dti-1305	77	67	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	77	68	targets	target	NOUN
dti-1305	77	69	(	(	PUNCT
dti-1305	77	70	for	for	ADP
dti-1305	77	71	review	review	NOUN
dti-1305	77	72	,	,	PUNCT
dti-1305	77	73	see	see	VERB
dti-1305	77	74	linares	linare	NOUN
dti-1305	77	75	et	et	PROPN
dti-1305	77	76	al	al	PROPN
dti-1305	77	77	.	.	PROPN
dti-1305	77	78	2006	2006	NUM
dti-1305	77	79	)	)	PUNCT
dti-1305	77	80	.	.	PUNCT
dti-1305	78	1	purine	purine	NOUN
dti-1305	78	2	salvage	salvage	NOUN
dti-1305	78	3	pathway	pathway	NOUN
dti-1305	78	4	some	some	DET
dti-1305	78	5	striking	striking	ADJ
dti-1305	78	6	differences	difference	NOUN
dti-1305	78	7	between	between	ADP
dti-1305	78	8	parasites	parasite	NOUN
dti-1305	78	9	and	and	CCONJ
dti-1305	78	10	their	their	PRON
dti-1305	78	11	mammalian	mammalian	ADJ
dti-1305	78	12	host	host	NOUN
dti-1305	78	13	are	be	AUX
dti-1305	78	14	apparent	apparent	ADJ
dti-1305	78	15	in	in	ADP
dti-1305	78	16	purine	purine	NOUN
dti-1305	78	17	metabolism	metabolism	NOUN
dti-1305	78	18	.	.	PUNCT
dti-1305	79	1	unlike	unlike	ADP
dti-1305	79	2	their	their	PRON
dti-1305	79	3	mammalian	mammalian	ADJ
dti-1305	79	4	host	host	NOUN
dti-1305	79	5	,	,	PUNCT
dti-1305	79	6	most	most	ADJ
dti-1305	79	7	parasites	parasite	NOUN
dti-1305	79	8	lack	lack	VERB
dti-1305	79	9	the	the	DET
dti-1305	79	10	de	de	X
dti-1305	79	11	novo	novo	NOUN
dti-1305	79	12	purine	purine	NOUN
dti-1305	79	13	biosynthetic	biosynthetic	ADJ
dti-1305	79	14	mechanisms	mechanism	NOUN
dti-1305	79	15	and	and	CCONJ
dti-1305	79	16	rely	rely	VERB
dti-1305	79	17	on	on	ADP
dti-1305	79	18	salvage	salvage	NOUN
dti-1305	79	19	pathways	pathway	NOUN
dti-1305	79	20	to	to	PART
dti-1305	79	21	meet	meet	VERB
dti-1305	79	22	their	their	PRON
dti-1305	79	23	purine	purine	NOUN
dti-1305	79	24	needs	need	NOUN
dti-1305	79	25	.	.	PUNCT
dti-1305	80	1	there	there	PRON
dti-1305	80	2	are	be	VERB
dti-1305	80	3	suffi	suffi	NOUN
dti-1305	80	4	cient	cient	NOUN
dti-1305	80	5	distinctions	distinction	NOUN
dti-1305	80	6	between	between	ADP
dti-1305	80	7	enzymes	enzyme	NOUN
dti-1305	80	8	of	of	ADP
dti-1305	80	9	the	the	DET
dti-1305	80	10	purine	purine	NOUN
dti-1305	80	11	salvage	salvage	NOUN
dti-1305	80	12	pathway	pathway	NOUN
dti-1305	80	13	in	in	ADP
dti-1305	80	14	host	host	NOUN
dti-1305	80	15	and	and	CCONJ
dti-1305	80	16	parasite	parasite	NOUN
dti-1305	80	17	that	that	PRON
dti-1305	80	18	can	can	AUX
dti-1305	80	19	be	be	AUX
dti-1305	80	20	exploited	exploit	VERB
dti-1305	80	21	to	to	PART
dti-1305	80	22	design	design	VERB
dti-1305	80	23	specifi	specifi	PROPN
dti-1305	80	24	c	c	PROPN
dti-1305	80	25	inhibitors	inhibitor	NOUN
dti-1305	80	26	or	or	CCONJ
dti-1305	80	27	“	"	PUNCT
dti-1305	80	28	subversive	subversive	ADJ
dti-1305	80	29	substrates	substrate	NOUN
dti-1305	80	30	”	"	PUNCT
dti-1305	80	31	for	for	ADP
dti-1305	80	32	the	the	DET
dti-1305	80	33	parasitic	parasitic	ADJ
dti-1305	80	34	enzymes	enzyme	NOUN
dti-1305	80	35	.	.	PUNCT
dti-1305	81	1	furthermore	furthermore	ADV
dti-1305	81	2	,	,	PUNCT
dti-1305	81	3	the	the	DET
dti-1305	81	4	specifi	specifi	PROPN
dti-1305	81	5	cities	city	NOUN
dti-1305	81	6	of	of	ADP
dti-1305	81	7	purine	purine	NOUN
dti-1305	81	8	transport	transport	NOUN
dti-1305	81	9	,	,	PUNCT
dti-1305	81	10	the	the	DET
dti-1305	81	11	fi	fi	NOUN
dti-1305	81	12	rst	rst	ADJ
dti-1305	81	13	step	step	NOUN
dti-1305	81	14	in	in	ADP
dti-1305	81	15	purine	purine	NOUN
dti-1305	81	16	salvage	salvage	NOUN
dti-1305	81	17	,	,	PUNCT
dti-1305	81	18	differ	differ	VERB
dti-1305	81	19	signifi	signifi	NOUN
dti-1305	81	20	cantly	cantly	ADV
dti-1305	81	21	between	between	ADP
dti-1305	81	22	parasites	parasite	NOUN
dti-1305	81	23	and	and	CCONJ
dti-1305	81	24	their	their	PRON
dti-1305	81	25	mammalian	mammalian	ADJ
dti-1305	81	26	host	host	NOUN
dti-1305	81	27	to	to	PART
dti-1305	81	28	allow	allow	VERB
dti-1305	81	29	selective	selective	ADJ
dti-1305	81	30	inhibitor	inhibitor	NOUN
dti-1305	81	31	design	design	NOUN
dti-1305	81	32	(	(	PUNCT
dti-1305	81	33	for	for	ADP
dti-1305	81	34	review	review	NOUN
dti-1305	81	35	see	see	VERB
dti-1305	81	36	el	el	PROPN
dti-1305	81	37	kouni	kouni	PROPN
dti-1305	81	38	,	,	PUNCT
dti-1305	81	39	2003	2003	NUM
dti-1305	81	40	)	)	PUNCT
dti-1305	81	41	.	.	PUNCT
dti-1305	82	1	polyamine	polyamine	NOUN
dti-1305	82	2	biosynthesis	biosynthesis	VERB
dti-1305	82	3	the	the	DET
dti-1305	82	4	ability	ability	NOUN
dti-1305	82	5	to	to	PART
dti-1305	82	6	synthesize	synthesize	VERB
dti-1305	82	7	polyamines	polyamine	NOUN
dti-1305	82	8	(	(	PUNCT
dti-1305	82	9	fig	fig	NOUN
dti-1305	82	10	.	.	PUNCT
dti-1305	83	1	2	2	NUM
dti-1305	83	2	)	)	PUNCT
dti-1305	83	3	is	be	AUX
dti-1305	83	4	vitally	vitally	ADV
dti-1305	83	5	important	important	ADJ
dti-1305	83	6	for	for	ADP
dti-1305	83	7	the	the	DET
dti-1305	83	8	proliferation	proliferation	NOUN
dti-1305	83	9	of	of	ADP
dti-1305	83	10	bloodstream	bloodstream	NOUN
dti-1305	83	11	hat	hat	NOUN
dti-1305	83	12	in	in	ADP
dti-1305	83	13	an	an	DET
dti-1305	83	14	environment	environment	NOUN
dti-1305	83	15	defi	defi	NOUN
dti-1305	83	16	cient	cient	NOUN
dti-1305	83	17	in	in	ADP
dti-1305	83	18	polyamines	polyamine	NOUN
dti-1305	83	19	.	.	PUNCT
dti-1305	84	1	drug	drug	NOUN
dti-1305	84	2	target	target	NOUN
dti-1305	84	3	insights	insight	NOUN
dti-1305	84	4	2007	2007	NUM
dti-1305	84	5	:	:	PUNCT
dti-1305	84	6	2	2	NUM
dti-1305	84	7	133	133	NUM
dti-1305	84	8	target	target	NOUN
dti-1305	84	9	for	for	ADP
dti-1305	84	10	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	84	11	and	and	CCONJ
dti-1305	84	12	antileishmanial	antileishmanial	ADJ
dti-1305	84	13	drug	drug	NOUN
dti-1305	84	14	design	design	NOUN
dti-1305	84	15	trypanothione	trypanothione	NOUN
dti-1305	84	16	reductase	reductase	NOUN
dti-1305	84	17	(	(	PUNCT
dti-1305	84	18	tr	tr	VERB
dti-1305	84	19	)	)	PUNCT
dti-1305	84	20	and	and	CCONJ
dti-1305	84	21	the	the	DET
dti-1305	84	22	synthetic	synthetic	ADJ
dti-1305	84	23	enzyme	enzyme	NOUN
dti-1305	84	24	of	of	ADP
dti-1305	84	25	trypanothione	trypanothione	NOUN
dti-1305	84	26	metabolism	metabolism	NOUN
dti-1305	84	27	found	find	VERB
dti-1305	84	28	in	in	ADP
dti-1305	84	29	trypanosomatids	trypanosomatid	NOUN
dti-1305	84	30	exemplify	exemplify	VERB
dti-1305	84	31	unique	unique	ADJ
dti-1305	84	32	features	feature	NOUN
dti-1305	84	33	of	of	ADP
dti-1305	84	34	the	the	DET
dti-1305	84	35	organisms	organism	NOUN
dti-1305	84	36	.	.	PUNCT
dti-1305	85	1	as	as	SCONJ
dti-1305	85	2	shown	show	VERB
dti-1305	85	3	in	in	ADP
dti-1305	85	4	figure	figure	NOUN
dti-1305	85	5	2	2	NUM
dti-1305	85	6	,	,	PUNCT
dti-1305	85	7	trypanothione	trypanothione	NOUN
dti-1305	85	8	synthesis	synthesis	NOUN
dti-1305	85	9	proceeds	proceed	NOUN
dti-1305	85	10	from	from	ADP
dti-1305	85	11	glutathione	glutathione	NOUN
dti-1305	85	12	;	;	PUNCT
dti-1305	85	13	the	the	DET
dti-1305	85	14	similar	similar	ADJ
dti-1305	85	15	redox	redox	NOUN
dti-1305	85	16	potentials	potential	NOUN
dti-1305	85	17	allow	allow	VERB
dti-1305	85	18	for	for	SCONJ
dti-1305	85	19	nonenzymatic	nonenzymatic	ADJ
dti-1305	85	20	thiol	thiol	NOUN
dti-1305	85	21	-	-	PUNCT
dti-1305	85	22	disulfi	disulfi	ADJ
dti-1305	85	23	de	de	PROPN
dti-1305	85	24	exchange	exchange	NOUN
dti-1305	85	25	reactions	reaction	NOUN
dti-1305	85	26	to	to	PART
dti-1305	85	27	occur	occur	VERB
dti-1305	85	28	(	(	PUNCT
dti-1305	85	29	fairlamb	fairlamb	NOUN
dti-1305	85	30	and	and	CCONJ
dti-1305	85	31	cerami	cerami	NOUN
dti-1305	85	32	,	,	PUNCT
dti-1305	85	33	1992	1992	NUM
dti-1305	85	34	)	)	PUNCT
dti-1305	85	35	.	.	PUNCT
dti-1305	86	1	considerable	considerable	ADJ
dti-1305	86	2	advances	advance	NOUN
dti-1305	86	3	have	have	AUX
dti-1305	86	4	been	be	AUX
dti-1305	86	5	made	make	VERB
dti-1305	86	6	in	in	ADP
dti-1305	86	7	characterization	characterization	NOUN
dti-1305	86	8	and	and	CCONJ
dti-1305	86	9	inhibitor	inhibitor	NOUN
dti-1305	86	10	design	design	NOUN
dti-1305	86	11	against	against	ADP
dti-1305	86	12	tr	tr	VERB
dti-1305	86	13	.	.	PUNCT
dti-1305	87	1	the	the	DET
dti-1305	87	2	key	key	ADJ
dti-1305	87	3	enzyme	enzyme	NOUN
dti-1305	87	4	of	of	ADP
dti-1305	87	5	the	the	DET
dti-1305	87	6	two	two	NUM
dti-1305	87	7	-	-	PUNCT
dti-1305	87	8	step	step	NOUN
dti-1305	87	9	trypanothione	trypanothione	NOUN
dti-1305	87	10	biosynthesis	biosynthesis	NOUN
dti-1305	87	11	,	,	PUNCT
dti-1305	87	12	glutathionyl	glutathionyl	NOUN
dti-1305	87	13	spermidine	spermidine	NOUN
dti-1305	87	14	synthetase	synthetase	NOUN
dti-1305	87	15	,	,	PUNCT
dti-1305	87	16	was	be	AUX
dti-1305	87	17	isolated	isolate	VERB
dti-1305	87	18	,	,	PUNCT
dti-1305	87	19	partially	partially	ADV
dti-1305	87	20	sequenced	sequence	VERB
dti-1305	87	21	and	and	CCONJ
dti-1305	87	22	kinetically	kinetically	ADV
dti-1305	87	23	analyzed	analyze	VERB
dti-1305	87	24	(	(	PUNCT
dti-1305	87	25	koenig	koenig	PROPN
dti-1305	87	26	et	et	PROPN
dti-1305	87	27	al	al	PROPN
dti-1305	87	28	.	.	PROPN
dti-1305	87	29	1997	1997	NUM
dti-1305	87	30	)	)	PUNCT
dti-1305	87	31	.	.	PUNCT
dti-1305	88	1	the	the	DET
dti-1305	88	2	utilization	utilization	NOUN
dti-1305	88	3	of	of	ADP
dti-1305	88	4	trypanothione	trypanothione	NOUN
dti-1305	88	5	for	for	ADP
dti-1305	88	6	the	the	DET
dti-1305	88	7	reduction	reduction	NOUN
dti-1305	88	8	of	of	ADP
dti-1305	88	9	hydroperoxides	hydroperoxide	NOUN
dti-1305	88	10	has	have	AUX
dti-1305	88	11	remained	remain	VERB
dti-1305	88	12	a	a	DET
dti-1305	88	13	matter	matter	NOUN
dti-1305	88	14	of	of	ADP
dti-1305	88	15	debate	debate	NOUN
dti-1305	88	16	.	.	PUNCT
dti-1305	89	1	a	a	DET
dti-1305	89	2	trypanothione	trypanothione	NOUN
dti-1305	89	3	peroxide	peroxide	NOUN
dti-1305	89	4	activity	activity	NOUN
dti-1305	89	5	,	,	PUNCT
dti-1305	89	6	presumed	presume	VERB
dti-1305	89	7	to	to	PART
dti-1305	89	8	substitute	substitute	VERB
dti-1305	89	9	for	for	ADP
dti-1305	89	10	the	the	DET
dti-1305	89	11	glutathione	glutathione	NOUN
dti-1305	89	12	peroxide	peroxide	NOUN
dti-1305	89	13	activity	activity	NOUN
dti-1305	89	14	typical	typical	ADJ
dti-1305	89	15	of	of	ADP
dti-1305	89	16	host	host	NOUN
dti-1305	89	17	metabolism	metabolism	NOUN
dti-1305	89	18	(	(	PUNCT
dti-1305	89	19	flohé	flohé	ADJ
dti-1305	89	20	,	,	PUNCT
dti-1305	89	21	1989	1989	NUM
dti-1305	89	22	)	)	PUNCT
dti-1305	89	23	,	,	PUNCT
dti-1305	89	24	was	be	AUX
dti-1305	89	25	observed	observe	VERB
dti-1305	89	26	in	in	ADP
dti-1305	89	27	crude	crude	ADJ
dti-1305	89	28	extracts	extract	NOUN
dti-1305	89	29	of	of	ADP
dti-1305	89	30	various	various	ADJ
dti-1305	89	31	trypanosomatids	trypanosomatid	NOUN
dti-1305	89	32	(	(	PUNCT
dti-1305	89	33	henderson	henderson	PROPN
dti-1305	89	34	et	et	PROPN
dti-1305	89	35	al	al	PROPN
dti-1305	89	36	.	.	PROPN
dti-1305	89	37	1987a	1987a	NUM
dti-1305	89	38	)	)	PUNCT
dti-1305	89	39	.	.	PUNCT
dti-1305	90	1	consistent	consistent	ADJ
dti-1305	90	2	failures	failure	NOUN
dti-1305	90	3	to	to	PART
dti-1305	90	4	isolate	isolate	VERB
dti-1305	90	5	putative	putative	ADJ
dti-1305	90	6	trypanothione	trypanothione	NOUN
dti-1305	90	7	peroxidases	peroxidase	NOUN
dti-1305	90	8	,	,	PUNCT
dti-1305	90	9	and	and	CCONJ
dti-1305	90	10	substantial	substantial	ADJ
dti-1305	90	11	spontaneous	spontaneous	ADJ
dti-1305	90	12	reaction	reaction	NOUN
dti-1305	90	13	rates	rate	NOUN
dti-1305	90	14	between	between	ADP
dti-1305	90	15	trypanothione	trypanothione	NOUN
dti-1305	90	16	and	and	CCONJ
dti-1305	90	17	hydrogen	hydrogen	NOUN
dti-1305	90	18	peroxide	peroxide	NOUN
dti-1305	90	19	,	,	PUNCT
dti-1305	90	20	led	lead	VERB
dti-1305	90	21	to	to	ADP
dti-1305	90	22	the	the	DET
dti-1305	90	23	conclusion	conclusion	NOUN
dti-1305	90	24	that	that	SCONJ
dti-1305	90	25	trypanothione	trypanothione	NOUN
dti-1305	90	26	-	-	PUNCT
dti-1305	90	27	dependent	dependent	ADJ
dti-1305	90	28	peroxide	peroxide	NOUN
dti-1305	90	29	metabolism	metabolism	NOUN
dti-1305	90	30	may	may	AUX
dti-1305	90	31	represent	represent	VERB
dti-1305	90	32	a	a	DET
dti-1305	90	33	non	non	ADJ
dti-1305	90	34	-	-	ADJ
dti-1305	90	35	enzymatic	enzymatic	ADJ
dti-1305	90	36	event	event	NOUN
dti-1305	90	37	(	(	PUNCT
dti-1305	90	38	carnieri	carnieri	PROPN
dti-1305	90	39	et	et	PROPN
dti-1305	90	40	al	al	PROPN
dti-1305	90	41	.	.	PROPN
dti-1305	90	42	1993	1993	NUM
dti-1305	90	43	)	)	PUNCT
dti-1305	90	44	.	.	PUNCT
dti-1305	91	1	recent	recent	ADJ
dti-1305	91	2	discoveries	discovery	NOUN
dti-1305	91	3	have	have	AUX
dti-1305	91	4	demonstrated	demonstrate	VERB
dti-1305	91	5	(	(	PUNCT
dti-1305	91	6	nogoceke	nogoceke	PROPN
dti-1305	91	7	et	et	PROPN
dti-1305	91	8	al	al	PROPN
dti-1305	91	9	.	.	PROPN
dti-1305	91	10	1997	1997	NUM
dti-1305	91	11	)	)	PUNCT
dti-1305	91	12	that	that	SCONJ
dti-1305	91	13	the	the	DET
dti-1305	91	14	reduction	reduction	NOUN
dti-1305	91	15	of	of	ADP
dti-1305	91	16	peroxides	peroxide	NOUN
dti-1305	91	17	by	by	ADP
dti-1305	91	18	trypanothione	trypanothione	NOUN
dti-1305	91	19	is	be	AUX
dti-1305	91	20	an	an	DET
dti-1305	91	21	enzymatic	enzymatic	ADJ
dti-1305	91	22	process	process	NOUN
dti-1305	91	23	,	,	PUNCT
dti-1305	91	24	but	but	CCONJ
dti-1305	91	25	in	in	ADP
dti-1305	91	26	contrast	contrast	NOUN
dti-1305	91	27	to	to	ADP
dti-1305	91	28	previous	previous	ADJ
dti-1305	91	29	expectations	expectation	NOUN
dti-1305	91	30	,	,	PUNCT
dti-1305	91	31	is	be	AUX
dti-1305	91	32	catalyzed	catalyze	VERB
dti-1305	91	33	by	by	ADP
dti-1305	91	34	two	two	NUM
dti-1305	91	35	distinct	distinct	ADJ
dti-1305	91	36	proteins	protein	NOUN
dti-1305	91	37	in	in	ADP
dti-1305	91	38	concert	concert	NOUN
dti-1305	91	39	(	(	PUNCT
dti-1305	91	40	flohé	flohé	ADJ
dti-1305	91	41	,	,	PUNCT
dti-1305	91	42	1998	1998	NUM
dti-1305	91	43	)	)	PUNCT
dti-1305	91	44	.	.	PUNCT
dti-1305	92	1	lipoamide	lipoamide	ADJ
dti-1305	92	2	dehydrogenase	dehydrogenase	NOUN
dti-1305	92	3	(	(	PUNCT
dti-1305	92	4	lipdh	lipdh	NOUN
dti-1305	92	5	)	)	PUNCT
dti-1305	92	6	is	be	AUX
dti-1305	92	7	another	another	PRON
dti-1305	92	8	fl	fl	NOUN
dti-1305	92	9	avoprotein	avoprotein	VERB
dti-1305	92	10	dependent	dependent	ADJ
dti-1305	92	11	enzyme	enzyme	NOUN
dti-1305	92	12	,	,	PUNCT
dti-1305	92	13	which	which	PRON
dti-1305	92	14	has	have	AUX
dti-1305	92	15	been	be	AUX
dti-1305	92	16	discussed	discuss	VERB
dti-1305	92	17	as	as	ADP
dti-1305	92	18	a	a	DET
dti-1305	92	19	target	target	NOUN
dti-1305	92	20	molecule	molecule	NOUN
dti-1305	92	21	for	for	ADP
dti-1305	92	22	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	92	23	therapy	therapy	NOUN
dti-1305	92	24	.	.	PUNCT
dti-1305	93	1	in	in	ADP
dti-1305	93	2	t.	t.	PROPN
dti-1305	93	3	cruzi	cruzi	PROPN
dti-1305	93	4	,	,	PUNCT
dti-1305	93	5	an	an	DET
dti-1305	93	6	organism	organism	NOUN
dti-1305	93	7	highly	highly	ADV
dti-1305	93	8	susceptible	susceptible	ADJ
dti-1305	93	9	to	to	ADP
dti-1305	93	10	oxidative	oxidative	ADJ
dti-1305	93	11	stress	stress	NOUN
dti-1305	93	12	,	,	PUNCT
dti-1305	93	13	lipdh	lipdh	NOUN
dti-1305	93	14	participates	participate	VERB
dti-1305	93	15	in	in	ADP
dti-1305	93	16	the	the	DET
dti-1305	93	17	redox	redox	ADJ
dti-1305	93	18	cycling	cycling	NOUN
dti-1305	93	19	of	of	ADP
dti-1305	93	20	nifurtimox	nifurtimox	PROPN
dti-1305	93	21	,	,	PUNCT
dti-1305	93	22	one	one	NUM
dti-1305	93	23	of	of	ADP
dti-1305	93	24	the	the	DET
dti-1305	93	25	most	most	ADV
dti-1305	93	26	effective	effective	ADJ
dti-1305	93	27	anti	anti	ADJ
dti-1305	93	28	-	-	ADJ
dti-1305	93	29	chagas	chagas	ADJ
dti-1305	93	30	agents	agent	NOUN
dti-1305	93	31	(	(	PUNCT
dti-1305	93	32	krauth	krauth	PROPN
dti-1305	93	33	-	-	PUNCT
dti-1305	93	34	siegel	siegel	PROPN
dti-1305	93	35	and	and	CCONJ
dti-1305	93	36	schöneck	schöneck	NOUN
dti-1305	93	37	,	,	PUNCT
dti-1305	93	38	1995	1995	NUM
dti-1305	93	39	)	)	PUNCT
dti-1305	93	40	.	.	PUNCT
dti-1305	94	1	trypanothione	trypanothione	NOUN
dti-1305	94	2	reductase	reductase	NOUN
dti-1305	94	3	as	as	ADP
dti-1305	94	4	a	a	DET
dti-1305	94	5	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	94	6	target	target	NOUN
dti-1305	94	7	in	in	ADP
dti-1305	94	8	the	the	DET
dti-1305	94	9	pre	pre	ADJ
dti-1305	94	10	-	-	ADJ
dti-1305	94	11	genomic	genomic	ADJ
dti-1305	94	12	era	era	NOUN
dti-1305	94	13	investigation	investigation	NOUN
dti-1305	94	14	of	of	ADP
dti-1305	94	15	mode	mode	NOUN
dti-1305	94	16	of	of	ADP
dti-1305	94	17	action	action	NOUN
dti-1305	94	18	of	of	ADP
dti-1305	94	19	arsenical	arsenical	ADJ
dti-1305	94	20	drugs	drug	NOUN
dti-1305	94	21	and	and	CCONJ
dti-1305	94	22	glutathione	glutathione	NOUN
dti-1305	94	23	biosynthesis	biosynthesis	NOUN
dti-1305	94	24	inhibitor	inhibitor	NOUN
dti-1305	94	25	,	,	PUNCT
dti-1305	94	26	buthionine	buthionine	NOUN
dti-1305	94	27	sulfoximine	sulfoximine	NOUN
dti-1305	94	28	(	(	PUNCT
dti-1305	94	29	bso	bso	PROPN
dti-1305	94	30	)	)	PUNCT
dti-1305	94	31	,	,	PUNCT
dti-1305	94	32	gave	give	VERB
dti-1305	94	33	rise	rise	NOUN
dti-1305	94	34	to	to	ADP
dti-1305	94	35	the	the	DET
dti-1305	94	36	discovery	discovery	NOUN
dti-1305	94	37	of	of	ADP
dti-1305	94	38	trypanothione	trypanothione	NOUN
dti-1305	94	39	,	,	PUNCT
dti-1305	94	40	unique	unique	ADJ
dti-1305	94	41	to	to	ADP
dti-1305	94	42	trypanosomes	trypanosome	NOUN
dti-1305	94	43	and	and	CCONJ
dti-1305	94	44	absent	absent	ADJ
dti-1305	94	45	from	from	ADP
dti-1305	94	46	the	the	DET
dti-1305	94	47	mammalian	mammalian	ADJ
dti-1305	94	48	cells	cell	NOUN
dti-1305	94	49	(	(	PUNCT
dti-1305	94	50	fairlamb	fairlamb	PROPN
dti-1305	94	51	et	et	PROPN
dti-1305	94	52	al	al	PROPN
dti-1305	94	53	.	.	PROPN
dti-1305	94	54	1985	1985	NUM
dti-1305	94	55	)	)	PUNCT
dti-1305	94	56	.	.	PUNCT
dti-1305	95	1	in	in	ADP
dti-1305	95	2	mammals	mammal	NOUN
dti-1305	95	3	,	,	PUNCT
dti-1305	95	4	potential	potential	ADJ
dti-1305	95	5	redox	redox	ADJ
dti-1305	95	6	damage	damage	NOUN
dti-1305	95	7	meets	meet	VERB
dti-1305	95	8	the	the	DET
dti-1305	95	9	glutathione	glutathione	NOUN
dti-1305	95	10	(	(	PUNCT
dti-1305	95	11	gsh)-based	gsh)-base	VERB
dti-1305	95	12	system	system	NOUN
dti-1305	95	13	as	as	ADP
dti-1305	95	14	a	a	DET
dti-1305	95	15	fi	fi	NOUN
dti-1305	95	16	rst	rst	NOUN
dti-1305	95	17	defense	defense	NOUN
dti-1305	95	18	,	,	PUNCT
dti-1305	95	19	during	during	ADP
dti-1305	95	20	the	the	DET
dti-1305	95	21	course	course	NOUN
dti-1305	95	22	of	of	ADP
dti-1305	95	23	which	which	DET
dti-1305	95	24	glutathione	glutathione	NOUN
dti-1305	95	25	disulfi	disulfi	PROPN
dti-1305	95	26	de	de	X
dti-1305	95	27	(	(	PUNCT
dti-1305	95	28	gssg	gssg	VERB
dti-1305	95	29	)	)	PUNCT
dti-1305	95	30	is	be	AUX
dti-1305	95	31	formed	form	VERB
dti-1305	95	32	(	(	PUNCT
dti-1305	95	33	equation	equation	NOUN
dti-1305	95	34	1	1	NUM
dti-1305	95	35	)	)	PUNCT
dti-1305	95	36	.	.	PUNCT
dti-1305	96	1	regeneration	regeneration	NOUN
dti-1305	96	2	of	of	ADP
dti-1305	96	3	protective	protective	ADJ
dti-1305	96	4	gsh	gsh	NOUN
dti-1305	96	5	from	from	ADP
dti-1305	96	6	gssg	gssg	ADJ
dti-1305	96	7	is	be	AUX
dti-1305	96	8	catalyzed	catalyze	VERB
dti-1305	96	9	by	by	ADP
dti-1305	96	10	gr	gr	PROPN
dti-1305	96	11	.	.	PUNCT
dti-1305	96	12	in	in	ADP
dti-1305	96	13	trypanosomes	trypanosome	NOUN
dti-1305	96	14	and	and	CCONJ
dti-1305	96	15	leishmanias	leishmania	VERB
dti-1305	96	16	an	an	DET
dti-1305	96	17	analogous	analogous	ADJ
dti-1305	96	18	system	system	NOUN
dti-1305	96	19	has	have	AUX
dti-1305	96	20	evolved	evolve	VERB
dti-1305	96	21	(	(	PUNCT
dti-1305	96	22	fairlamb	fairlamb	NOUN
dti-1305	96	23	and	and	CCONJ
dti-1305	96	24	cerami	cerami	NOUN
dti-1305	96	25	,	,	PUNCT
dti-1305	96	26	1992	1992	NUM
dti-1305	96	27	)	)	PUNCT
dti-1305	96	28	insofar	insofar	ADV
dti-1305	96	29	as	as	SCONJ
dti-1305	96	30	the	the	DET
dti-1305	96	31	disulfi	disulfi	PROPN
dti-1305	96	32	de	de	X
dti-1305	96	33	(	(	PUNCT
dti-1305	96	34	t[sh]2	t[sh]2	PROPN
dti-1305	96	35	)	)	PUNCT
dti-1305	96	36	differs	differ	VERB
dti-1305	96	37	from	from	ADP
dti-1305	96	38	gssg	gssg	VERB
dti-1305	96	39	by	by	ADP
dti-1305	96	40	the	the	DET
dti-1305	96	41	presence	presence	NOUN
dti-1305	96	42	of	of	ADP
dti-1305	96	43	a	a	DET
dti-1305	96	44	spermidine	spermidine	NOUN
dti-1305	96	45	cross	cross	NOUN
dti-1305	96	46	-	-	NOUN
dti-1305	96	47	link	link	NOUN
dti-1305	96	48	between	between	ADP
dti-1305	96	49	the	the	DET
dti-1305	96	50	two	two	NUM
dti-1305	96	51	glycyl	glycyl	NOUN
dti-1305	96	52	carboxyl	carboxyl	NOUN
dti-1305	96	53	groups	group	NOUN
dti-1305	96	54	(	(	PUNCT
dti-1305	96	55	compare	compare	AUX
dti-1305	96	56	gssg	gssg	VERB
dti-1305	96	57	and	and	CCONJ
dti-1305	96	58	t[s]2	t[s]2	NOUN
dti-1305	96	59	)	)	PUNCT
dti-1305	96	60	.	.	PUNCT
dti-1305	97	1	the	the	DET
dti-1305	97	2	enzyme	enzyme	NOUN
dti-1305	97	3	tr	tr	VERB
dti-1305	97	4	reduces	reduce	VERB
dti-1305	97	5	t[s]2	t[s]2	NOUN
dti-1305	97	6	to	to	PART
dti-1305	97	7	dithiol	dithiol	VERB
dti-1305	97	8	t[sh]2	t[sh]2	PROPN
dti-1305	97	9	in	in	ADP
dti-1305	97	10	a	a	DET
dti-1305	97	11	manner	manner	NOUN
dti-1305	97	12	analogous	analogous	ADJ
dti-1305	97	13	to	to	ADP
dti-1305	97	14	gr	gr	PROPN
dti-1305	97	15	(	(	PUNCT
dti-1305	97	16	fig	fig	NOUN
dti-1305	97	17	.	.	PUNCT
dti-1305	98	1	3	3	NUM
dti-1305	98	2	)	)	PUNCT
dti-1305	98	3	.	.	PUNCT
dti-1305	99	1	with	with	ADP
dti-1305	99	2	this	this	DET
dti-1305	99	3	discovery	discovery	NOUN
dti-1305	99	4	of	of	ADP
dti-1305	99	5	a	a	DET
dti-1305	99	6	fundamental	fundamental	ADJ
dti-1305	99	7	metabolic	metabolic	NOUN
dti-1305	99	8	difference	difference	NOUN
dti-1305	99	9	,	,	PUNCT
dti-1305	99	10	tr	tr	VERB
dti-1305	99	11	was	be	AUX
dti-1305	99	12	proposed	propose	VERB
dti-1305	99	13	and	and	CCONJ
dti-1305	99	14	amplifi	amplifi	VERB
dti-1305	99	15	ed	ed	NOUN
dti-1305	99	16	further	far	ADV
dti-1305	99	17	as	as	ADP
dti-1305	99	18	a	a	DET
dti-1305	99	19	target	target	NOUN
dti-1305	99	20	for	for	ADP
dti-1305	99	21	the	the	DET
dti-1305	99	22	rational	rational	ADJ
dti-1305	99	23	design	design	NOUN
dti-1305	99	24	of	of	ADP
dti-1305	99	25	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	99	26	and	and	CCONJ
dti-1305	99	27	antileishmanial	antileishmanial	ADJ
dti-1305	99	28	drugs	drug	NOUN
dti-1305	99	29	(	(	PUNCT
dti-1305	99	30	fairlamb	fairlamb	PROPN
dti-1305	99	31	et	et	PROPN
dti-1305	99	32	al	al	PROPN
dti-1305	99	33	.	.	PROPN
dti-1305	99	34	1985	1985	NUM
dti-1305	99	35	;	;	PUNCT
dti-1305	99	36	shames	shame	VERB
dti-1305	99	37	et	et	PROPN
dti-1305	99	38	al	al	PROPN
dti-1305	99	39	.	.	PROPN
dti-1305	99	40	1986	1986	NUM
dti-1305	99	41	;	;	PUNCT
dti-1305	99	42	benson	benson	PROPN
dti-1305	99	43	et	et	PROPN
dti-1305	99	44	al	al	PROPN
dti-1305	99	45	.	.	PROPN
dti-1305	99	46	1992	1992	NUM
dti-1305	99	47	;	;	PUNCT
dti-1305	99	48	hunter	hunter	NOUN
dti-1305	99	49	et	et	PROPN
dti-1305	99	50	al	al	PROPN
dti-1305	99	51	.	.	PROPN
dti-1305	99	52	1992	1992	NUM
dti-1305	99	53	;	;	PUNCT
dti-1305	99	54	schirmer	schirmer	PROPN
dti-1305	99	55	et	et	PROPN
dti-1305	99	56	al	al	PROPN
dti-1305	99	57	.	.	PROPN
dti-1305	99	58	1995	1995	NUM
dti-1305	99	59	)	)	PUNCT
dti-1305	99	60	.	.	PUNCT
dti-1305	100	1	unlike	unlike	ADP
dti-1305	100	2	human	human	ADJ
dti-1305	100	3	hosts	host	NOUN
dti-1305	100	4	,	,	PUNCT
dti-1305	100	5	trypanosomes	trypanosome	NOUN
dti-1305	100	6	contain	contain	VERB
dti-1305	100	7	tr	tr	VERB
dti-1305	100	8	instead	instead	ADV
dti-1305	100	9	of	of	ADP
dti-1305	100	10	analogous	analogous	ADJ
dti-1305	100	11	enzyme	enzyme	NOUN
dti-1305	100	12	gr	gr	NOUN
dti-1305	100	13	to	to	PART
dti-1305	100	14	process	process	VERB
dti-1305	100	15	their	their	PRON
dti-1305	100	16	cognate	cognate	NOUN
dti-1305	100	17	substrates	substrate	NOUN
dti-1305	100	18	trypanothione	trypanothione	NOUN
dti-1305	100	19	and	and	CCONJ
dti-1305	100	20	glutathione	glutathione	NOUN
dti-1305	100	21	,	,	PUNCT
dti-1305	100	22	nadph	nadph	ADJ
dti-1305	100	23	nadp+	nadp+	X
dti-1305	100	24	gr	gr	PROPN
dti-1305	100	25	gssg	gssg	VERB
dti-1305	100	26	gsh	gsh	PROPN
dti-1305	100	27	nadph	nadph	PROPN
dti-1305	100	28	nadp+	nadp+	PROPN
dti-1305	101	1	tr	tr	NOUN
dti-1305	101	2	t[s]2	t[s]2	NOUN
dti-1305	101	3	t[sh]2	t[sh]2	ADP
dti-1305	101	4	reactive	reactive	ADJ
dti-1305	101	5	oxygen	oxygen	NOUN
dti-1305	101	6	species	specie	NOUN
dti-1305	101	7	host	host	NOUN
dti-1305	101	8	parasite	parasite	NOUN
dti-1305	101	9	figure	figure	NOUN
dti-1305	101	10	3	3	NUM
dti-1305	101	11	.	.	NOUN
dti-1305	101	12	outline	outline	NOUN
dti-1305	101	13	of	of	ADP
dti-1305	101	14	glutathione	glutathione	NOUN
dti-1305	101	15	and	and	CCONJ
dti-1305	101	16	trypanothione	trypanothione	NOUN
dti-1305	101	17	based	base	VERB
dti-1305	101	18	redox	redox	NOUN
dti-1305	101	19	defences	defence	NOUN
dti-1305	101	20	.	.	PUNCT
dti-1305	102	1	+	+	ADJ
dti-1305	102	2	h3n	h3n	ADJ
dti-1305	102	3	co2	co2	NOUN
dti-1305	102	4	conh	conh	NOUN
dti-1305	102	5	conh	conh	NOUN
dti-1305	102	6	s	s	PART
dti-1305	102	7	s	s	NOUN
dti-1305	102	8	co2	co2	VERB
dti-1305	102	9	+	+	ADJ
dti-1305	102	10	h3n	h3n	ADJ
dti-1305	102	11	co2	co2	NOUN
dti-1305	102	12	conh	conh	NOUN
dti-1305	102	13	conh	conh	NOUN
dti-1305	102	14	co2	co2	NOUN
dti-1305	102	15	glutathion	glutathion	NOUN
dti-1305	102	16	disulphide	disulphide	ADV
dti-1305	102	17	(	(	PUNCT
dti-1305	102	18	gssg	gssg	ADJ
dti-1305	102	19	)	)	PUNCT
dti-1305	102	20	gsh	gsh	PROPN
dti-1305	102	21	gssg	gssg	VERB
dti-1305	102	22	(	(	PUNCT
dti-1305	102	23	1	1	NUM
dti-1305	102	24	)	)	PUNCT
dti-1305	102	25	+	+	ADJ
dti-1305	102	26	h3n	h3n	ADJ
dti-1305	102	27	co2	co2	NOUN
dti-1305	102	28	conh	conh	NOUN
dti-1305	102	29	conh	conh	NOUN
dti-1305	102	30	s	s	PART
dti-1305	102	31	s	s	NOUN
dti-1305	102	32	conh	conh	NOUN
dti-1305	102	33	+	+	NOUN
dti-1305	102	34	h3n	h3n	NOUN
dti-1305	102	35	co2	co2	NOUN
dti-1305	102	36	conh	conh	NOUN
dti-1305	102	37	conh	conh	NOUN
dti-1305	102	38	conh	conh	PROPN
dti-1305	102	39	nh2	nh2	PROPN
dti-1305	103	1	+	+	CCONJ
dti-1305	104	1	trypanothion	trypanothion	NOUN
dti-1305	104	2	disulphide	disulphide	NOUN
dti-1305	104	3	(	(	PUNCT
dti-1305	104	4	t[s]2	t[s]2	NOUN
dti-1305	104	5	)	)	PUNCT
dti-1305	104	6	scheme	scheme	NOUN
dti-1305	104	7	1	1	NUM
dti-1305	104	8	.	.	PUNCT
dti-1305	104	9	glutathion	glutathion	NOUN
dti-1305	104	10	and	and	CCONJ
dti-1305	104	11	trypanothione	trypanothione	NOUN
dti-1305	104	12	.	.	PUNCT
dti-1305	105	1	drug	drug	NOUN
dti-1305	105	2	target	target	NOUN
dti-1305	105	3	insights	insight	NOUN
dti-1305	105	4	2007	2007	NUM
dti-1305	105	5	:	:	PUNCT
dti-1305	105	6	2	2	NUM
dti-1305	105	7	134	134	NUM
dti-1305	105	8	khan	khan	NOUN
dti-1305	105	9	respectively	respectively	ADV
dti-1305	105	10	.	.	PUNCT
dti-1305	106	1	parasite	parasite	NOUN
dti-1305	106	2	tr	tr	VERB
dti-1305	106	3	does	do	AUX
dti-1305	106	4	not	not	PART
dti-1305	106	5	process	process	VERB
dti-1305	106	6	gssg	gssg	VERB
dti-1305	106	7	and	and	CCONJ
dti-1305	106	8	host	host	NOUN
dti-1305	106	9	gr	gr	NOUN
dti-1305	106	10	does	do	AUX
dti-1305	106	11	not	not	PART
dti-1305	106	12	reduce	reduce	VERB
dti-1305	106	13	t[s]2	t[s]2	NOUN
dti-1305	106	14	(	(	PUNCT
dti-1305	106	15	shames	shame	VERB
dti-1305	106	16	et	et	PROPN
dti-1305	106	17	al	al	PROPN
dti-1305	106	18	.	.	PROPN
dti-1305	106	19	1986	1986	NUM
dti-1305	106	20	;	;	PUNCT
dti-1305	106	21	krauth	krauth	NOUN
dti-1305	106	22	-	-	PUNCT
dti-1305	106	23	siegel	siegel	PROPN
dti-1305	106	24	et	et	PROPN
dti-1305	106	25	al	al	PROPN
dti-1305	106	26	.	.	PROPN
dti-1305	106	27	1987	1987	NUM
dti-1305	106	28	)	)	PUNCT
dti-1305	106	29	.	.	PUNCT
dti-1305	107	1	selective	selective	ADJ
dti-1305	107	2	inhibitor	inhibitor	NOUN
dti-1305	107	3	design	design	NOUN
dti-1305	107	4	is	be	AUX
dti-1305	107	5	probable	probable	ADJ
dti-1305	107	6	,	,	PUNCT
dti-1305	107	7	due	due	ADP
dti-1305	107	8	to	to	ADP
dti-1305	107	9	the	the	DET
dti-1305	107	10	mutually	mutually	ADV
dti-1305	107	11	exclusive	exclusive	ADJ
dti-1305	107	12	recognition	recognition	NOUN
dti-1305	107	13	and	and	CCONJ
dti-1305	107	14	rejection	rejection	NOUN
dti-1305	107	15	of	of	ADP
dti-1305	107	16	cognate	cognate	NOUN
dti-1305	107	17	substrates	substrate	NOUN
dti-1305	107	18	between	between	ADP
dti-1305	107	19	host	host	NOUN
dti-1305	107	20	and	and	CCONJ
dti-1305	107	21	parasite	parasite	NOUN
dti-1305	107	22	(	(	PUNCT
dti-1305	107	23	shames	shame	VERB
dti-1305	107	24	et	et	PROPN
dti-1305	107	25	al	al	PROPN
dti-1305	107	26	.	.	PROPN
dti-1305	107	27	1986	1986	NUM
dti-1305	107	28	;	;	PUNCT
dti-1305	107	29	krauth	krauth	NOUN
dti-1305	107	30	-	-	PUNCT
dti-1305	107	31	siegel	siegel	PROPN
dti-1305	107	32	et	et	PROPN
dti-1305	107	33	al	al	PROPN
dti-1305	107	34	.	.	PROPN
dti-1305	107	35	1987	1987	NUM
dti-1305	107	36	;	;	PUNCT
dti-1305	107	37	schirmer	schirmer	PROPN
dti-1305	107	38	et	et	PROPN
dti-1305	107	39	al	al	PROPN
dti-1305	107	40	.	.	PROPN
dti-1305	107	41	1995	1995	NUM
dti-1305	107	42	)	)	PUNCT
dti-1305	107	43	.	.	PUNCT
dti-1305	108	1	efficient	efficient	ADJ
dti-1305	108	2	selective	selective	ADJ
dti-1305	108	3	blockade	blockade	NOUN
dti-1305	108	4	of	of	ADP
dti-1305	108	5	tr	tr	PRON
dti-1305	108	6	would	would	AUX
dti-1305	108	7	be	be	AUX
dti-1305	108	8	expected	expect	VERB
dti-1305	108	9	to	to	PART
dti-1305	108	10	compromise	compromise	VERB
dti-1305	108	11	the	the	DET
dti-1305	108	12	redox	redox	NOUN
dti-1305	108	13	defences	defence	NOUN
dti-1305	108	14	of	of	ADP
dti-1305	108	15	the	the	DET
dti-1305	108	16	parasites	parasite	NOUN
dti-1305	108	17	,	,	PUNCT
dti-1305	108	18	increasing	increase	VERB
dti-1305	108	19	their	their	PRON
dti-1305	108	20	sensitivity	sensitivity	NOUN
dti-1305	108	21	to	to	ADP
dti-1305	108	22	redox	redox	NOUN
dti-1305	108	23	-	-	PUNCT
dti-1305	108	24	damage	damage	NOUN
dti-1305	108	25	based	base	VERB
dti-1305	108	26	drugs	drug	NOUN
dti-1305	108	27	,	,	PUNCT
dti-1305	108	28	e.g.	e.g.	ADV
dti-1305	108	29	nifurtimox	nifurtimox	PROPN
dti-1305	108	30	.	.	PUNCT
dti-1305	109	1	a	a	DET
dti-1305	109	2	tr	tr	NOUN
dti-1305	109	3	inhibitor	inhibitor	NOUN
dti-1305	109	4	might	might	AUX
dti-1305	109	5	be	be	AUX
dti-1305	109	6	expected	expect	VERB
dti-1305	109	7	to	to	PART
dti-1305	109	8	be	be	AUX
dti-1305	109	9	drug	drug	NOUN
dti-1305	109	10	in	in	ADP
dti-1305	109	11	its	its	PRON
dti-1305	109	12	own	own	ADJ
dti-1305	109	13	right	right	NOUN
dti-1305	109	14	or	or	CCONJ
dti-1305	109	15	for	for	ADP
dti-1305	109	16	co	co	NOUN
dti-1305	109	17	-	-	NOUN
dti-1305	109	18	administration	administration	NOUN
dti-1305	109	19	with	with	ADP
dti-1305	109	20	a	a	DET
dti-1305	109	21	redoxactive	redoxactive	ADJ
dti-1305	109	22	drug	drug	NOUN
dti-1305	109	23	e.g.	e.g.	ADV
dti-1305	109	24	nifurtimox	nifurtimox	PROPN
dti-1305	109	25	.	.	PUNCT
dti-1305	110	1	the	the	DET
dti-1305	110	2	later	later	ADJ
dti-1305	110	3	case	case	NOUN
dti-1305	110	4	may	may	AUX
dti-1305	110	5	even	even	ADV
dti-1305	110	6	provide	provide	VERB
dti-1305	110	7	synergy	synergy	NOUN
dti-1305	110	8	,	,	PUNCT
dti-1305	110	9	allowing	allow	VERB
dti-1305	110	10	use	use	NOUN
dti-1305	110	11	of	of	ADP
dti-1305	110	12	lowered	lower	VERB
dti-1305	110	13	doses	dose	NOUN
dti-1305	110	14	of	of	ADP
dti-1305	110	15	the	the	DET
dti-1305	110	16	redox	redox	ADJ
dti-1305	110	17	drug	drug	NOUN
dti-1305	110	18	(	(	PUNCT
dti-1305	110	19	chan	chan	PROPN
dti-1305	110	20	et	et	PROPN
dti-1305	110	21	al	al	PROPN
dti-1305	110	22	.	.	PROPN
dti-1305	110	23	1998	1998	NUM
dti-1305	110	24	)	)	PUNCT
dti-1305	110	25	.	.	PUNCT
dti-1305	111	1	tr	tr	PRON
dti-1305	111	2	is	be	AUX
dti-1305	111	3	a	a	DET
dti-1305	111	4	member	member	NOUN
dti-1305	111	5	of	of	ADP
dti-1305	111	6	the	the	DET
dti-1305	111	7	large	large	ADJ
dti-1305	111	8	well	well	ADV
dti-1305	111	9	-	-	PUNCT
dti-1305	111	10	characterized	characterize	VERB
dti-1305	111	11	protein	protein	NOUN
dti-1305	111	12	family	family	NOUN
dti-1305	111	13	of	of	ADP
dti-1305	111	14	fad	fad	NOUN
dti-1305	111	15	-	-	PUNCT
dti-1305	111	16	dependent	dependent	ADJ
dti-1305	111	17	nadph	nadph	ADJ
dti-1305	111	18	oxidoreductases	oxidoreductase	NOUN
dti-1305	111	19	(	(	PUNCT
dti-1305	111	20	reviewed	review	VERB
dti-1305	111	21	in	in	ADP
dti-1305	111	22	williams	williams	PROPN
dti-1305	111	23	,	,	PUNCT
dti-1305	111	24	1992	1992	NUM
dti-1305	111	25	)	)	PUNCT
dti-1305	111	26	and	and	CCONJ
dti-1305	111	27	share	share	VERB
dti-1305	111	28	close	close	ADJ
dti-1305	111	29	structural	structural	ADJ
dti-1305	111	30	and	and	CCONJ
dti-1305	111	31	mechanistic	mechanistic	ADJ
dti-1305	111	32	similarities	similarity	NOUN
dti-1305	111	33	with	with	ADP
dti-1305	111	34	that	that	PRON
dti-1305	111	35	of	of	ADP
dti-1305	111	36	gr	gr	PROPN
dti-1305	111	37	(	(	PUNCT
dti-1305	111	38	summarized	summarize	VERB
dti-1305	111	39	in	in	ADP
dti-1305	111	40	table	table	NOUN
dti-1305	111	41	2	2	NUM
dti-1305	111	42	)	)	PUNCT
dti-1305	111	43	.	.	PUNCT
dti-1305	112	1	it	it	PRON
dti-1305	112	2	is	be	AUX
dti-1305	112	3	a	a	DET
dti-1305	112	4	dimeric	dimeric	ADJ
dti-1305	112	5	protein	protein	NOUN
dti-1305	112	6	of	of	ADP
dti-1305	112	7	monomer	monomer	NOUN
dti-1305	112	8	molecular	molecular	ADJ
dti-1305	112	9	mass	mass	PROPN
dti-1305	112	10	52kda	52kda	NOUN
dti-1305	112	11	,	,	PUNCT
dti-1305	112	12	providing	provide	VERB
dti-1305	112	13	fad	fad	NOUN
dti-1305	112	14	-	-	PUNCT
dti-1305	112	15	binding	binding	ADJ
dti-1305	112	16	,	,	PUNCT
dti-1305	112	17	nadph	nadph	ADJ
dti-1305	112	18	-	-	PUNCT
dti-1305	112	19	binding	binding	ADJ
dti-1305	112	20	,	,	PUNCT
dti-1305	112	21	central	central	ADJ
dti-1305	112	22	and	and	CCONJ
dti-1305	112	23	interface	interface	NOUN
dti-1305	112	24	domains	domain	NOUN
dti-1305	112	25	.	.	PUNCT
dti-1305	113	1	there	there	PRON
dti-1305	113	2	are	be	VERB
dti-1305	113	3	two	two	NUM
dti-1305	113	4	identical	identical	ADJ
dti-1305	113	5	active	active	ADJ
dti-1305	113	6	sites	site	NOUN
dti-1305	113	7	,	,	PUNCT
dti-1305	113	8	formed	form	VERB
dti-1305	113	9	by	by	ADP
dti-1305	113	10	residues	residue	NOUN
dti-1305	113	11	of	of	ADP
dti-1305	113	12	the	the	DET
dti-1305	113	13	fad	fad	NOUN
dti-1305	113	14	,	,	PUNCT
dti-1305	113	15	nadph	nadph	ADJ
dti-1305	113	16	,	,	PUNCT
dti-1305	113	17	and	and	CCONJ
dti-1305	113	18	central	central	ADJ
dti-1305	113	19	domains	domain	NOUN
dti-1305	113	20	of	of	ADP
dti-1305	113	21	one	one	NUM
dti-1305	113	22	monomer	monomer	NOUN
dti-1305	113	23	and	and	CCONJ
dti-1305	113	24	the	the	DET
dti-1305	113	25	interface	interface	NOUN
dti-1305	113	26	domain	domain	NOUN
dti-1305	113	27	of	of	ADP
dti-1305	113	28	the	the	DET
dti-1305	113	29	other	other	ADJ
dti-1305	113	30	(	(	PUNCT
dti-1305	113	31	fig	fig	NOUN
dti-1305	113	32	.	.	PUNCT
dti-1305	113	33	4	4	NUM
dti-1305	113	34	)	)	PUNCT
dti-1305	113	35	.	.	PUNCT
dti-1305	114	1	validating	validate	VERB
dti-1305	114	2	suitability	suitability	NOUN
dti-1305	114	3	of	of	ADP
dti-1305	114	4	trypanothione	trypanothione	NOUN
dti-1305	114	5	reductase	reductase	NOUN
dti-1305	114	6	as	as	ADP
dti-1305	114	7	a	a	DET
dti-1305	114	8	target	target	NOUN
dti-1305	114	9	to	to	PART
dti-1305	114	10	validate	validate	VERB
dti-1305	114	11	tr	tr	NOUN
dti-1305	114	12	as	as	ADP
dti-1305	114	13	a	a	DET
dti-1305	114	14	viable	viable	ADJ
dti-1305	114	15	target	target	NOUN
dti-1305	114	16	for	for	ADP
dti-1305	114	17	rational	rational	ADJ
dti-1305	114	18	drug	drug	NOUN
dti-1305	114	19	design	design	NOUN
dti-1305	114	20	,	,	PUNCT
dti-1305	114	21	inhibition	inhibition	NOUN
dti-1305	114	22	of	of	ADP
dti-1305	114	23	tr	tr	VERB
dti-1305	114	24	in	in	ADP
dti-1305	114	25	vitro	vitro	X
dti-1305	114	26	should	should	AUX
dti-1305	114	27	correlate	correlate	VERB
dti-1305	114	28	with	with	ADP
dti-1305	114	29	an	an	DET
dti-1305	114	30	observable	observable	ADJ
dti-1305	114	31	effect	effect	NOUN
dti-1305	114	32	in	in	ADP
dti-1305	114	33	vivo	vivo	NOUN
dti-1305	114	34	.	.	PUNCT
dti-1305	115	1	this	this	PRON
dti-1305	115	2	is	be	AUX
dti-1305	115	3	a	a	DET
dti-1305	115	4	diffi	diffi	ADJ
dti-1305	115	5	cult	cult	NOUN
dti-1305	115	6	test	test	NOUN
dti-1305	115	7	to	to	PART
dti-1305	115	8	satisfy	satisfy	VERB
dti-1305	115	9	unambiguously	unambiguously	ADV
dti-1305	115	10	;	;	PUNCT
dti-1305	115	11	biochemical	biochemical	ADJ
dti-1305	115	12	and	and	CCONJ
dti-1305	115	13	molecular	molecular	ADJ
dti-1305	115	14	biological	biological	ADJ
dti-1305	115	15	attempts	attempt	NOUN
dti-1305	115	16	had	have	AUX
dti-1305	115	17	been	be	AUX
dti-1305	115	18	made	make	VERB
dti-1305	115	19	to	to	PART
dti-1305	115	20	probe	probe	VERB
dti-1305	115	21	tr	tr	VERB
dti-1305	115	22	as	as	ADP
dti-1305	115	23	a	a	DET
dti-1305	115	24	reasonable	reasonable	ADJ
dti-1305	115	25	drug	drug	NOUN
dti-1305	115	26	target	target	NOUN
dti-1305	115	27	.	.	PUNCT
dti-1305	116	1	in	in	ADP
dti-1305	116	2	absolute	absolute	ADJ
dti-1305	116	3	terms	term	NOUN
dti-1305	116	4	,	,	PUNCT
dti-1305	116	5	disruption	disruption	NOUN
dti-1305	116	6	or	or	CCONJ
dti-1305	116	7	deletion	deletion	NOUN
dti-1305	116	8	of	of	ADP
dti-1305	116	9	the	the	DET
dti-1305	116	10	tr	tr	NOUN
dti-1305	116	11	genes	gene	NOUN
dti-1305	116	12	in	in	ADP
dti-1305	116	13	parasites	parasite	NOUN
dti-1305	116	14	should	should	AUX
dti-1305	116	15	be	be	AUX
dti-1305	116	16	lethal	lethal	ADJ
dti-1305	116	17	.	.	PUNCT
dti-1305	117	1	over	over	ADP
dti-1305	117	2	-	-	PUNCT
dti-1305	117	3	expression	expression	NOUN
dti-1305	117	4	of	of	ADP
dti-1305	117	5	tr	tr	VERB
dti-1305	117	6	in	in	ADP
dti-1305	117	7	transfected	transfecte	VERB
dti-1305	117	8	l.	l.	PROPN
dti-1305	117	9	donovani	donovani	PROPN
dti-1305	117	10	promastigotes	promastigote	NOUN
dti-1305	117	11	was	be	AUX
dti-1305	117	12	not	not	PART
dti-1305	117	13	found	find	VERB
dti-1305	117	14	to	to	PART
dti-1305	117	15	alter	alter	VERB
dti-1305	117	16	the	the	DET
dti-1305	117	17	sensitivity	sensitivity	NOUN
dti-1305	117	18	to	to	ADP
dti-1305	117	19	hydrogen	hydrogen	NOUN
dti-1305	117	20	peroxide	peroxide	NOUN
dti-1305	117	21	indicating	indicate	VERB
dti-1305	117	22	that	that	SCONJ
dti-1305	117	23	the	the	DET
dti-1305	117	24	regeneration	regeneration	NOUN
dti-1305	117	25	of	of	ADP
dti-1305	117	26	t[sh]2	t[sh]2	NUM
dti-1305	117	27	from	from	ADP
dti-1305	117	28	its	its	PRON
dti-1305	117	29	disulfi	disulfi	NOUN
dti-1305	117	30	de	de	X
dti-1305	117	31	after	after	ADP
dti-1305	117	32	oxidative	oxidative	ADJ
dti-1305	117	33	challenge	challenge	NOUN
dti-1305	117	34	is	be	AUX
dti-1305	117	35	not	not	PART
dti-1305	117	36	the	the	DET
dti-1305	117	37	ratedetermining	ratedetermine	VERB
dti-1305	117	38	feature	feature	NOUN
dti-1305	117	39	of	of	ADP
dti-1305	117	40	the	the	DET
dti-1305	117	41	defense	defense	NOUN
dti-1305	117	42	system	system	NOUN
dti-1305	117	43	(	(	PUNCT
dti-1305	117	44	kelly	kelly	PROPN
dti-1305	117	45	et	et	PROPN
dti-1305	117	46	al	al	PROPN
dti-1305	117	47	.	.	PROPN
dti-1305	117	48	1993	1993	NUM
dti-1305	117	49	)	)	PUNCT
dti-1305	117	50	.	.	PUNCT
dti-1305	118	1	over	over	ADP
dti-1305	118	2	-	-	PUNCT
dti-1305	118	3	expression	expression	NOUN
dti-1305	118	4	of	of	ADP
dti-1305	118	5	tr	tr	VERB
dti-1305	118	6	in	in	ADP
dti-1305	118	7	t.	t.	PROPN
dti-1305	118	8	cruzi	cruzi	PROPN
dti-1305	118	9	led	lead	VERB
dti-1305	118	10	to	to	PART
dti-1305	118	11	gene	gene	NOUN
dti-1305	118	12	rearrangements	rearrangement	NOUN
dti-1305	118	13	when	when	SCONJ
dti-1305	118	14	antisense	antisense	NOUN
dti-1305	118	15	modulation	modulation	NOUN
dti-1305	118	16	of	of	ADP
dti-1305	118	17	tr	tr	NOUN
dti-1305	118	18	expression	expression	NOUN
dti-1305	118	19	was	be	AUX
dti-1305	118	20	attempted	attempt	VERB
dti-1305	118	21	(	(	PUNCT
dti-1305	118	22	tovar	tovar	PROPN
dti-1305	118	23	and	and	CCONJ
dti-1305	118	24	fairlamb	fairlamb	PROPN
dti-1305	118	25	,	,	PUNCT
dti-1305	118	26	1996	1996	NUM
dti-1305	118	27	)	)	PUNCT
dti-1305	118	28	.	.	PUNCT
dti-1305	119	1	disruption	disruption	NOUN
dti-1305	119	2	of	of	ADP
dti-1305	119	3	two	two	NUM
dti-1305	119	4	of	of	ADP
dti-1305	119	5	the	the	DET
dti-1305	119	6	tr	tr	NOUN
dti-1305	119	7	alleles	allele	NOUN
dti-1305	119	8	of	of	ADP
dti-1305	119	9	leishmania	leishmania	NOUN
dti-1305	119	10	failed	fail	VERB
dti-1305	119	11	to	to	PART
dti-1305	119	12	produce	produce	VERB
dti-1305	119	13	a	a	DET
dti-1305	119	14	null	null	ADJ
dti-1305	119	15	mutant	mutant	NOUN
dti-1305	119	16	,	,	PUNCT
dti-1305	119	17	and	and	CCONJ
dti-1305	119	18	actually	actually	ADV
dti-1305	119	19	produced	produce	VERB
dti-1305	119	20	a	a	DET
dti-1305	119	21	third	third	ADJ
dti-1305	119	22	copy	copy	NOUN
dti-1305	119	23	of	of	ADP
dti-1305	119	24	tr	tr	VERB
dti-1305	119	25	gene	gene	NOUN
dti-1305	119	26	by	by	ADP
dti-1305	119	27	genomic	genomic	ADJ
dti-1305	119	28	rearrangement	rearrangement	NOUN
dti-1305	119	29	to	to	ADP
dti-1305	119	30	a	a	DET
dti-1305	119	31	larger	large	ADJ
dti-1305	119	32	chromosome	chromosome	NOUN
dti-1305	119	33	(	(	PUNCT
dti-1305	119	34	dumas	dumas	PROPN
dti-1305	119	35	et	et	PROPN
dti-1305	119	36	al	al	PROPN
dti-1305	119	37	.	.	PROPN
dti-1305	119	38	1997	1997	NUM
dti-1305	119	39	)	)	PUNCT
dti-1305	119	40	.	.	PUNCT
dti-1305	120	1	down	down	ADP
dti-1305	120	2	-	-	PUNCT
dti-1305	120	3	regulation	regulation	NOUN
dti-1305	120	4	of	of	ADP
dti-1305	120	5	tr	tr	VERB
dti-1305	120	6	using	use	VERB
dti-1305	120	7	a	a	DET
dti-1305	120	8	trans	trans	ADJ
dti-1305	120	9	-	-	ADJ
dti-1305	120	10	dominant	dominant	ADJ
dti-1305	120	11	mutation	mutation	NOUN
dti-1305	120	12	strategy	strategy	NOUN
dti-1305	120	13	demonstrated	demonstrate	VERB
dti-1305	120	14	that	that	SCONJ
dti-1305	120	15	even	even	ADV
dti-1305	120	16	with	with	ADP
dti-1305	120	17	only	only	ADV
dti-1305	120	18	15	15	NUM
dti-1305	120	19	%	%	NOUN
dti-1305	120	20	residual	residual	ADJ
dti-1305	120	21	tr	tr	NOUN
dti-1305	120	22	activity	activity	NOUN
dti-1305	120	23	,	,	PUNCT
dti-1305	120	24	promastigote	promastigote	ADJ
dti-1305	120	25	growth	growth	NOUN
dti-1305	120	26	is	be	AUX
dti-1305	120	27	still	still	ADV
dti-1305	120	28	supported	support	VERB
dti-1305	120	29	in	in	ADP
dti-1305	120	30	culture	culture	NOUN
dti-1305	120	31	(	(	PUNCT
dti-1305	120	32	tovar	tovar	PROPN
dti-1305	120	33	et	et	PROPN
dti-1305	120	34	al	al	PROPN
dti-1305	120	35	.	.	PROPN
dti-1305	120	36	1998a	1998a	NUM
dti-1305	120	37	)	)	PUNCT
dti-1305	120	38	.	.	PUNCT
dti-1305	121	1	it	it	PRON
dti-1305	121	2	was	be	AUX
dti-1305	121	3	proposed	propose	VERB
dti-1305	121	4	that	that	SCONJ
dti-1305	121	5	any	any	DET
dti-1305	121	6	rationally	rationally	ADV
dti-1305	121	7	designed	design	VERB
dti-1305	121	8	inhibitor	inhibitor	NOUN
dti-1305	121	9	of	of	ADP
dti-1305	121	10	tr	tr	PRON
dti-1305	121	11	must	must	AUX
dti-1305	121	12	attain	attain	VERB
dti-1305	121	13	>	>	PUNCT
dti-1305	121	14	85	85	NUM
dti-1305	121	15	%	%	NOUN
dti-1305	121	16	inhibition	inhibition	NOUN
dti-1305	121	17	for	for	ADP
dti-1305	121	18	activity	activity	NOUN
dti-1305	121	19	as	as	ADP
dti-1305	121	20	an	an	DET
dti-1305	121	21	antileishmanial	antileishmanial	ADJ
dti-1305	121	22	species	specie	NOUN
dti-1305	121	23	,	,	PUNCT
dti-1305	121	24	but	but	CCONJ
dti-1305	121	25	it	it	PRON
dti-1305	121	26	was	be	AUX
dti-1305	121	27	pointed	point	VERB
dti-1305	121	28	out	out	ADP
dti-1305	121	29	that	that	SCONJ
dti-1305	121	30	such	such	ADJ
dti-1305	121	31	cells	cell	NOUN
dti-1305	121	32	are	be	AUX
dti-1305	121	33	more	more	ADV
dti-1305	121	34	sensitive	sensitive	ADJ
dti-1305	121	35	to	to	ADP
dti-1305	121	36	oxidative	oxidative	ADJ
dti-1305	121	37	insult	insult	NOUN
dti-1305	121	38	,	,	PUNCT
dti-1305	121	39	such	such	ADJ
dti-1305	121	40	as	as	ADP
dti-1305	121	41	the	the	DET
dti-1305	121	42	oxidative	oxidative	ADJ
dti-1305	121	43	burst	burst	NOUN
dti-1305	121	44	of	of	ADP
dti-1305	121	45	macrophages	macrophage	NOUN
dti-1305	121	46	,	,	PUNCT
dti-1305	121	47	and	and	CCONJ
dti-1305	121	48	that	that	SCONJ
dti-1305	121	49	clinically	clinically	ADV
dti-1305	121	50	usable	usable	ADJ
dti-1305	121	51	tr	tr	NOUN
dti-1305	121	52	inhibitors	inhibitor	NOUN
dti-1305	121	53	may	may	AUX
dti-1305	121	54	need	need	VERB
dti-1305	121	55	to	to	PART
dti-1305	121	56	be	be	AUX
dti-1305	121	57	as	as	ADV
dti-1305	121	58	effective	effective	ADJ
dti-1305	121	59	in	in	ADP
dti-1305	121	60	vivo	vivo	NOUN
dti-1305	121	61	(	(	PUNCT
dti-1305	121	62	tovar	tovar	PROPN
dti-1305	121	63	et	et	PROPN
dti-1305	121	64	al	al	PROPN
dti-1305	121	65	.	.	PROPN
dti-1305	121	66	1998a	1998a	NUM
dti-1305	121	67	)	)	PUNCT
dti-1305	121	68	.	.	PUNCT
dti-1305	122	1	later	later	ADV
dti-1305	122	2	it	it	PRON
dti-1305	122	3	had	have	AUX
dti-1305	122	4	been	be	AUX
dti-1305	122	5	demonstrated	demonstrate	VERB
dti-1305	122	6	that	that	SCONJ
dti-1305	122	7	tr	tr	NOUN
dti-1305	122	8	absence	absence	NOUN
dti-1305	122	9	is	be	AUX
dti-1305	122	10	incompatible	incompatible	ADJ
dti-1305	122	11	with	with	ADP
dti-1305	122	12	parasite	parasite	ADJ
dti-1305	122	13	survival	survival	NOUN
dti-1305	122	14	and	and	CCONJ
dti-1305	122	15	validated	validate	VERB
dti-1305	122	16	tr	tr	NOUN
dti-1305	122	17	as	as	ADP
dti-1305	122	18	a	a	DET
dti-1305	122	19	bonafi	bonafi	PROPN
dti-1305	122	20	de	de	X
dti-1305	122	21	drug	drug	NOUN
dti-1305	122	22	target	target	NOUN
dti-1305	122	23	.	.	PUNCT
dti-1305	123	1	as	as	SCONJ
dti-1305	123	2	it	it	PRON
dti-1305	123	3	was	be	AUX
dti-1305	123	4	not	not	PART
dti-1305	123	5	possible	possible	ADJ
dti-1305	123	6	to	to	PART
dti-1305	123	7	obtain	obtain	VERB
dti-1305	123	8	viable	viable	ADJ
dti-1305	123	9	leishmania	leishmania	NOUN
dti-1305	123	10	devoid	devoid	ADJ
dti-1305	123	11	of	of	ADP
dti-1305	123	12	tr	tr	PUNCT
dti-1305	123	13	catalytic	catalytic	ADJ
dti-1305	123	14	activity	activity	NOUN
dti-1305	123	15	,	,	PUNCT
dti-1305	123	16	specifi	specifi	PROPN
dti-1305	123	17	c	c	NOUN
dti-1305	123	18	inhibitors	inhibitor	NOUN
dti-1305	123	19	of	of	ADP
dti-1305	123	20	this	this	DET
dti-1305	123	21	enzyme	enzyme	NOUN
dti-1305	123	22	are	be	AUX
dti-1305	123	23	likely	likely	ADJ
dti-1305	123	24	to	to	PART
dti-1305	123	25	be	be	AUX
dti-1305	123	26	useful	useful	ADJ
dti-1305	123	27	antileishmanial	antileishmanial	ADJ
dti-1305	123	28	agents	agent	NOUN
dti-1305	123	29	for	for	ADP
dti-1305	123	30	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	123	31	use	use	NOUN
dti-1305	123	32	(	(	PUNCT
dti-1305	123	33	tovar	tovar	PROPN
dti-1305	123	34	et	et	PROPN
dti-1305	123	35	al	al	PROPN
dti-1305	123	36	.	.	PROPN
dti-1305	123	37	1998b	1998b	NUM
dti-1305	123	38	)	)	PUNCT
dti-1305	123	39	.	.	PUNCT
dti-1305	124	1	sequence	sequence	NOUN
dti-1305	124	2	alignment	alignment	NOUN
dti-1305	124	3	of	of	ADP
dti-1305	124	4	trs	trs	PROPN
dti-1305	124	5	and	and	CCONJ
dti-1305	124	6	human	human	PROPN
dti-1305	124	7	grs	grs	PROPN
dti-1305	124	8	(	(	PUNCT
dti-1305	124	9	hgrs	hgrs	PROPN
dti-1305	124	10	)	)	PUNCT
dti-1305	124	11	showed	show	VERB
dti-1305	124	12	that	that	PRON
dti-1305	124	13	relative	relative	ADJ
dti-1305	124	14	to	to	ADP
dti-1305	124	15	tr	tr	PROPN
dti-1305	124	16	hgr	hgr	PROPN
dti-1305	124	17	has	have	VERB
dti-1305	124	18	an	an	DET
dti-1305	124	19	nterminal	nterminal	ADJ
dti-1305	124	20	extension	extension	NOUN
dti-1305	124	21	,	,	PUNCT
dti-1305	124	22	a	a	DET
dti-1305	124	23	c	c	NOUN
dti-1305	124	24	-	-	PUNCT
dti-1305	124	25	terminal	terminal	ADJ
dti-1305	124	26	truncation	truncation	NOUN
dti-1305	124	27	and	and	CCONJ
dti-1305	124	28	several	several	ADJ
dti-1305	124	29	deletion	deletion	NOUN
dti-1305	124	30	and	and	CCONJ
dti-1305	124	31	insertions	insertion	NOUN
dti-1305	124	32	throughout	throughout	ADP
dti-1305	124	33	the	the	DET
dti-1305	124	34	sequence	sequence	NOUN
dti-1305	124	35	.	.	PUNCT
dti-1305	125	1	the	the	DET
dti-1305	125	2	most	most	ADV
dti-1305	125	3	striking	striking	ADJ
dti-1305	125	4	regions	region	NOUN
dti-1305	125	5	of	of	ADP
dti-1305	125	6	homology	homology	NOUN
dti-1305	125	7	are	be	AUX
dti-1305	125	8	14	14	NUM
dti-1305	125	9	-	-	PUNCT
dti-1305	125	10	residue	residue	NOUN
dti-1305	125	11	sequence	sequence	NOUN
dti-1305	125	12	containing	contain	VERB
dti-1305	125	13	the	the	DET
dti-1305	125	14	redox	redox	ADJ
dti-1305	125	15	-	-	PUNCT
dti-1305	125	16	active	active	ADJ
dti-1305	125	17	cysteine	cysteine	NOUN
dti-1305	125	18	residues	residue	NOUN
dti-1305	125	19	and	and	CCONJ
dti-1305	125	20	the	the	DET
dti-1305	125	21	10	10	NUM
dti-1305	125	22	-	-	PUNCT
dti-1305	125	23	residue	residue	NOUN
dti-1305	125	24	sequence	sequence	NOUN
dti-1305	125	25	containing	contain	VERB
dti-1305	125	26	the	the	DET
dti-1305	125	27	active	active	ADJ
dti-1305	125	28	site	site	NOUN
dti-1305	125	29	histidine	histidine	NOUN
dti-1305	125	30	.	.	PUNCT
dti-1305	126	1	although	although	SCONJ
dti-1305	126	2	the	the	DET
dti-1305	126	3	disulfi	disulfi	ADJ
dti-1305	126	4	de	de	ADJ
dti-1305	126	5	-	-	ADJ
dti-1305	126	6	binding	binding	ADJ
dti-1305	126	7	site	site	NOUN
dti-1305	126	8	in	in	ADP
dti-1305	126	9	tr	tr	VERB
dti-1305	126	10	in	in	ADP
dti-1305	126	11	general	general	ADJ
dti-1305	126	12	rather	rather	ADV
dti-1305	126	13	closely	closely	ADV
dti-1305	126	14	resembles	resemble	VERB
dti-1305	126	15	that	that	PRON
dti-1305	126	16	for	for	ADP
dti-1305	126	17	gssg	gssg	VERB
dti-1305	126	18	in	in	ADP
dti-1305	126	19	gr	gr	PROPN
dti-1305	126	20	,	,	PUNCT
dti-1305	126	21	they	they	PRON
dti-1305	126	22	have	have	VERB
dti-1305	126	23	over	over	ADP
dti-1305	126	24	1000	1000	NUM
dti-1305	126	25	-	-	NUM
dti-1305	126	26	fold	fold	ADJ
dti-1305	126	27	selectivity	selectivity	NOUN
dti-1305	126	28	for	for	ADP
dti-1305	126	29	their	their	PRON
dti-1305	126	30	cognate	cognate	NOUN
dti-1305	126	31	substrates	substrate	NOUN
dti-1305	126	32	,	,	PUNCT
dti-1305	126	33	the	the	DET
dti-1305	126	34	molecular	molecular	ADJ
dti-1305	126	35	basis	basis	NOUN
dti-1305	126	36	for	for	ADP
dti-1305	126	37	which	which	PRON
dti-1305	126	38	involves	involve	VERB
dti-1305	126	39	size	size	NOUN
dti-1305	126	40	,	,	PUNCT
dti-1305	126	41	charge	charge	NOUN
dti-1305	126	42	and	and	CCONJ
dti-1305	126	43	hydrophobicity	hydrophobicity	NOUN
dti-1305	126	44	of	of	ADP
dti-1305	126	45	their	their	PRON
dti-1305	126	46	active	active	ADJ
dti-1305	126	47	sites	site	NOUN
dti-1305	126	48	.	.	PUNCT
dti-1305	127	1	tr	tr	VERB
dti-1305	127	2	binding	bind	VERB
dti-1305	127	3	site	site	NOUN
dti-1305	127	4	is	be	AUX
dti-1305	127	5	much	much	ADV
dti-1305	127	6	wider	wide	ADJ
dti-1305	127	7	in	in	ADP
dti-1305	127	8	the	the	DET
dti-1305	127	9	outer	outer	ADJ
dti-1305	127	10	region	region	NOUN
dti-1305	127	11	(	(	PUNCT
dti-1305	127	12	~22	~22	INTJ
dti-1305	127	13	å	å	X
dti-1305	127	14	×	×	NOUN
dti-1305	127	15	20	20	NUM
dti-1305	127	16	å	å	PROPN
dti-1305	127	17	×	×	NOUN
dti-1305	127	18	28	28	NUM
dti-1305	127	19	å	å	NOUN
dti-1305	127	20	)	)	PUNCT
dti-1305	127	21	due	due	ADP
dti-1305	127	22	to	to	ADP
dti-1305	127	23	different	different	ADJ
dti-1305	127	24	orientations	orientation	NOUN
dti-1305	127	25	of	of	ADP
dti-1305	127	26	two	two	NUM
dti-1305	127	27	helices	helix	NOUN
dti-1305	127	28	figure	figure	NOUN
dti-1305	127	29	4	4	NUM
dti-1305	127	30	.	.	PUNCT
dti-1305	127	31	structure	structure	NOUN
dti-1305	127	32	of	of	ADP
dti-1305	127	33	trypanothione	trypanothione	NOUN
dti-1305	127	34	reductase	reductase	NOUN
dti-1305	127	35	with	with	ADP
dti-1305	127	36	fad	fad	PROPN
dti-1305	127	37	,	,	PUNCT
dti-1305	127	38	nadph	nadph	ADJ
dti-1305	127	39	and	and	CCONJ
dti-1305	127	40	trypanothione	trypanothione	NOUN
dti-1305	127	41	bound	bind	VERB
dti-1305	127	42	(	(	PUNCT
dti-1305	127	43	modifi	modifi	PROPN
dti-1305	127	44	ed	ed	PROPN
dti-1305	127	45	from	from	ADP
dti-1305	127	46	bond	bond	PROPN
dti-1305	127	47	et	et	PROPN
dti-1305	127	48	al	al	PROPN
dti-1305	127	49	.	.	PROPN
dti-1305	127	50	1999	1999	NUM
dti-1305	127	51	)	)	PUNCT
dti-1305	127	52	.	.	PUNCT
dti-1305	128	1	fad	fad	PROPN
dti-1305	128	2	trypanothione	trypanothione	PROPN
dti-1305	128	3	nadph	nadph	ADJ
dti-1305	128	4	interface	interface	NOUN
dti-1305	128	5	drug	drug	NOUN
dti-1305	128	6	target	target	NOUN
dti-1305	128	7	insights	insight	NOUN
dti-1305	128	8	2007	2007	NUM
dti-1305	128	9	:	:	PUNCT
dti-1305	128	10	2	2	NUM
dti-1305	128	11	135	135	NUM
dti-1305	128	12	target	target	NOUN
dti-1305	128	13	for	for	ADP
dti-1305	128	14	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	128	15	and	and	CCONJ
dti-1305	128	16	antileishmanial	antileishmanial	ADJ
dti-1305	128	17	drug	drug	NOUN
dti-1305	128	18	design	design	NOUN
dti-1305	128	19	ta	ta	X
dti-1305	128	20	bl	bl	PROPN
dti-1305	128	21	e	e	PROPN
dti-1305	128	22	2	2	NUM
dti-1305	128	23	.	.	PUNCT
dti-1305	129	1	p	p	X
dti-1305	129	2	ro	ro	X
dti-1305	129	3	pe	pe	INTJ
dti-1305	129	4	rti	rti	PROPN
dti-1305	129	5	es	es	ADP
dti-1305	129	6	o	o	PROPN
dti-1305	130	1	f	f	X
dti-1305	130	2	t	t	X
dti-1305	131	1	ry	ry	PROPN
dti-1305	131	2	pa	pa	PROPN
dti-1305	131	3	no	no	INTJ
dti-1305	131	4	th	th	X
dti-1305	131	5	io	io	X
dti-1305	131	6	ne	ne	X
dti-1305	131	7	re	re	X
dti-1305	131	8	du	du	PROPN
dti-1305	131	9	ct	ct	PROPN
dti-1305	131	10	as	as	ADP
dti-1305	131	11	e	e	PROPN
dti-1305	131	12	an	an	PROPN
dti-1305	131	13	d	d	X
dti-1305	131	14	gl	gl	X
dti-1305	131	15	ut	ut	PROPN
dti-1305	131	16	at	at	ADP
dti-1305	131	17	hi	hi	ADV
dti-1305	131	18	on	on	ADP
dti-1305	131	19	e	e	X
dti-1305	131	20	re	re	VERB
dti-1305	131	21	du	du	PROPN
dti-1305	131	22	ct	ct	PROPN
dti-1305	131	23	as	as	ADP
dti-1305	131	24	e	e	PROPN
dti-1305	131	25	;	;	PUNCT
dti-1305	132	1	ta	ta	PART
dti-1305	132	2	ke	ke	PROPN
dti-1305	132	3	n	n	PRON
dti-1305	132	4	fro	fro	NOUN
dti-1305	132	5	m	m	NOUN
dti-1305	132	6	li	li	PROPN
dti-1305	132	7	te	te	PROPN
dti-1305	132	8	ra	ra	PROPN
dti-1305	132	9	tu	tu	PROPN
dti-1305	132	10	re	re	X
dti-1305	132	11	(	(	PUNCT
dti-1305	132	12	w	w	PROPN
dti-1305	132	13	ill	ill	PROPN
dti-1305	132	14	ia	ia	PROPN
dti-1305	133	1	m	m	PROPN
dti-1305	133	2	s	s	NOUN
dti-1305	133	3	et	et	PROPN
dti-1305	133	4	a	a	DET
dti-1305	133	5	l.	l.	PROPN
dti-1305	133	6	19	19	NUM
dti-1305	133	7	92	92	NUM
dti-1305	133	8	)	)	PUNCT
dti-1305	133	9	.	.	PUNCT
dti-1305	134	1	pr	pr	NOUN
dti-1305	134	2	op	op	NOUN
dti-1305	135	1	er	er	INTJ
dti-1305	135	2	ty	ty	INTJ
dti-1305	136	1	tr	tr	VERB
dti-1305	136	2	yp	yp	PROPN
dti-1305	136	3	an	an	DET
dti-1305	136	4	ot	ot	INTJ
dti-1305	136	5	hi	hi	INTJ
dti-1305	136	6	on	on	ADP
dti-1305	136	7	e	e	X
dti-1305	136	8	re	re	VERB
dti-1305	136	9	du	du	PROPN
dti-1305	136	10	ct	ct	PROPN
dti-1305	136	11	as	as	ADP
dti-1305	136	12	e	e	X
dti-1305	136	13	g	g	NOUN
dti-1305	136	14	lu	lu	PROPN
dti-1305	136	15	ta	ta	X
dti-1305	137	1	th	th	X
dti-1305	137	2	io	io	X
dti-1305	137	3	ne	ne	X
dti-1305	137	4	re	re	ADP
dti-1305	137	5	du	du	PROPN
dti-1305	137	6	ct	ct	PROPN
dti-1305	137	7	as	as	ADP
dti-1305	137	8	e	e	PROPN
dti-1305	137	9	c	c	NOUN
dti-1305	137	10	.	.	PUNCT
dti-1305	138	1	f	f	PROPN
dti-1305	139	1	as	as	SCONJ
dti-1305	139	2	ci	ci	PROPN
dti-1305	139	3	cu	cu	PROPN
dti-1305	139	4	la	la	PROPN
dti-1305	139	5	ta	ta	PROPN
dti-1305	139	6	l.	l.	PROPN
dti-1305	139	7	d	d	PROPN
dti-1305	139	8	on	on	ADP
dti-1305	139	9	ov	ov	PROPN
dti-1305	139	10	an	an	DET
dti-1305	139	11	i	i	NOUN
dti-1305	139	12	t.	t.	PROPN
dti-1305	139	13	c	c	PROPN
dti-1305	139	14	ru	ru	PROPN
dti-1305	139	15	zi	zi	PROPN
dti-1305	139	16	t.	t.	PROPN
dti-1305	139	17	c	c	PROPN
dti-1305	139	18	on	on	AUX
dti-1305	139	19	go	go	VERB
dti-1305	139	20	le	le	X
dti-1305	139	21	ns	ns	NUM
dti-1305	139	22	e	e	X
dti-1305	139	23	e	e	X
dti-1305	139	24	.c	.c	NOUN
dti-1305	140	1	ol	ol	PROPN
dti-1305	140	2	i	i	PRON
dti-1305	140	3	h	h	INTJ
dti-1305	141	1	um	um	INTJ
dti-1305	141	2	an	an	DET
dti-1305	141	3	fl	fl	INTJ
dti-1305	141	4	av	av	PROPN
dti-1305	141	5	in	in	ADP
dti-1305	141	6	fa	fa	PROPN
dti-1305	142	1	d	d	PROPN
dti-1305	142	2	n.	n.	PROPN
dti-1305	142	3	d.	d.	PROPN
dti-1305	142	4	fa	fa	PROPN
dti-1305	143	1	d	d	X
dti-1305	143	2	fa	fa	INTJ
dti-1305	143	3	d	d	X
dti-1305	143	4	fa	fa	X
dti-1305	143	5	d	d	X
dti-1305	143	6	fa	fa	PROPN
dti-1305	144	1	d	d	X
dti-1305	144	2	p	p	NOUN
dti-1305	145	1	yr	yr	INTJ
dti-1305	146	1	i	i	PROPN
dti-1305	146	2	d	d	PROPN
dti-1305	146	3	in	in	ADP
dti-1305	146	4	e	e	PROPN
dti-1305	146	5	di	di	X
dti-1305	146	6	nu	nu	PROPN
dti-1305	146	7	cl	cl	NOUN
dti-1305	147	1	eo	eo	NOUN
dti-1305	147	2	tid	tid	NOUN
dti-1305	147	3	e	e	NOUN
dti-1305	147	4	n	n	CCONJ
dti-1305	147	5	a	a	NOUN
dti-1305	147	6	d	d	X
dti-1305	147	7	p	p	X
dti-1305	147	8	h	h	NOUN
dti-1305	147	9	n	n	CCONJ
dti-1305	147	10	a	a	NOUN
dti-1305	147	11	d	d	X
dti-1305	147	12	p	p	X
dti-1305	147	13	h	h	NOUN
dti-1305	147	14	n	n	CCONJ
dti-1305	147	15	a	a	NOUN
dti-1305	147	16	d	d	X
dti-1305	147	17	p	p	X
dti-1305	147	18	h	h	NOUN
dti-1305	147	19	n	n	CCONJ
dti-1305	147	20	a	a	NOUN
dti-1305	147	21	d	d	X
dti-1305	147	22	p	p	X
dti-1305	147	23	h	h	NOUN
dti-1305	147	24	n	n	CCONJ
dti-1305	147	25	a	a	NOUN
dti-1305	147	26	d	d	X
dti-1305	147	27	p	p	X
dti-1305	147	28	h	h	NOUN
dti-1305	147	29	n	n	CCONJ
dti-1305	147	30	a	a	NOUN
dti-1305	147	31	d	d	X
dti-1305	147	32	p	p	PROPN
dti-1305	147	33	h	h	NOUN
dti-1305	147	34	s	s	PART
dti-1305	147	35	ub	ub	INTJ
dti-1305	147	36	un	un	PROPN
dti-1305	148	1	it	it	PRON
dti-1305	148	2	m	m	VERB
dti-1305	148	3	r	r	NOUN
dti-1305	148	4	(	(	PUNCT
dti-1305	148	5	d	d	NOUN
dti-1305	148	6	a	a	X
dti-1305	148	7	)	)	PUNCT
dti-1305	148	8	54	54	NUM
dti-1305	148	9	00	00	NUM
dti-1305	148	10	0	0	NUM
dti-1305	149	1	52	52	NUM
dti-1305	149	2	94	94	NUM
dti-1305	149	3	0	0	NUM
dti-1305	149	4	53	53	NUM
dti-1305	149	5	90	90	NUM
dti-1305	149	6	0	0	NUM
dti-1305	149	7	53	53	NUM
dti-1305	149	8	40	40	NUM
dti-1305	149	9	0	0	NUM
dti-1305	149	10	48	48	NUM
dti-1305	149	11	70	70	NUM
dti-1305	149	12	0	0	NUM
dti-1305	149	13	52	52	NUM
dti-1305	149	14	50	50	NUM
dti-1305	149	15	0	0	NUM
dti-1305	149	16	a	a	DET
dti-1305	149	17	m	m	NOUN
dti-1305	149	18	in	in	ADP
dti-1305	149	19	o	o	PROPN
dti-1305	149	20	ac	ac	PROPN
dti-1305	150	1	i	i	PROPN
dti-1305	150	2	d	d	PROPN
dti-1305	150	3	s/	s/	VERB
dti-1305	150	4	su	su	PROPN
dti-1305	150	5	bu	bu	PROPN
dti-1305	150	6	ni	ni	PROPN
dti-1305	150	7	t	t	PROPN
dti-1305	150	8	49	49	NUM
dti-1305	150	9	1	1	NUM
dti-1305	150	10	49	49	NUM
dti-1305	150	11	1	1	NUM
dti-1305	150	12	49	49	NUM
dti-1305	150	13	2	2	NUM
dti-1305	150	14	49	49	NUM
dti-1305	150	15	2	2	NUM
dti-1305	150	16	45	45	NUM
dti-1305	150	17	0	0	NUM
dti-1305	150	18	47	47	NUM
dti-1305	150	19	8	8	NUM
dti-1305	150	20	o	o	NOUN
dti-1305	150	21	lig	lig	PROPN
dti-1305	151	1	om	om	PROPN
dti-1305	151	2	er	er	INTJ
dti-1305	151	3	ic	ic	PROPN
dti-1305	151	4	s	s	VERB
dti-1305	152	1	tru	tru	PROPN
dti-1305	152	2	ct	ct	INTJ
dti-1305	152	3	ur	ur	INTJ
dti-1305	152	4	e	e	PROPN
dti-1305	152	5	di	di	X
dti-1305	152	6	m	m	PROPN
dti-1305	152	7	er	er	INTJ
dti-1305	152	8	di	di	INTJ
dti-1305	152	9	m	m	PROPN
dti-1305	152	10	er	er	INTJ
dti-1305	152	11	di	di	INTJ
dti-1305	152	12	m	m	PROPN
dti-1305	152	13	er	er	INTJ
dti-1305	152	14	di	di	INTJ
dti-1305	152	15	m	m	PROPN
dti-1305	152	16	er	er	INTJ
dti-1305	152	17	di	di	INTJ
dti-1305	152	18	m	m	PROPN
dti-1305	152	19	er	er	INTJ
dti-1305	152	20	di	di	INTJ
dti-1305	152	21	m	m	PROPN
dti-1305	152	22	er	er	INTJ
dti-1305	152	23	e	e	X
dti-1305	152	24	ox	ox	NOUN
dti-1305	152	25	,	,	PUNCT
dti-1305	152	26	λ	λ	PROPN
dti-1305	152	27	m	m	VERB
dti-1305	152	28	ax	ax	NOUN
dti-1305	152	29	(	(	PUNCT
dti-1305	152	30	n	n	X
dti-1305	152	31	m	m	VERB
dti-1305	152	32	)	)	PUNCT
dti-1305	153	1	46	46	NUM
dti-1305	153	2	4	4	NUM
dti-1305	153	3	46	46	NUM
dti-1305	153	4	3	3	NUM
dti-1305	153	5	46	46	NUM
dti-1305	153	6	1	1	NUM
dti-1305	153	7	46	46	NUM
dti-1305	153	8	4	4	NUM
dti-1305	153	9	46	46	NUM
dti-1305	153	10	2	2	NUM
dti-1305	153	11	46	46	NUM
dti-1305	153	12	0	0	NUM
dti-1305	153	13	ε	ε	PROPN
dti-1305	153	14	0	0	NUM
dti-1305	154	1	a	a	DET
dti-1305	154	2	t	t	NOUN
dti-1305	154	3	λ	λ	X
dti-1305	154	4	m	m	NOUN
dti-1305	154	5	ax	ax	NOUN
dti-1305	154	6	(	(	PUNCT
dti-1305	154	7	m	m	NOUN
dti-1305	154	8	m	m	VERB
dti-1305	154	9	–	–	PUNCT
dti-1305	154	10	1	1	NUM
dti-1305	154	11	cm	cm	NUM
dti-1305	154	12	–	–	PUNCT
dti-1305	154	13	1	1	NUM
dti-1305	154	14	)	)	PUNCT
dti-1305	154	15	11	11	NUM
dti-1305	154	16	.3	.3	NUM
dti-1305	154	17	11	11	NUM
dti-1305	154	18	.5	.5	NUM
dti-1305	154	19	11	11	NUM
dti-1305	155	1	.2	.2	NUM
dti-1305	155	2	10	10	NUM
dti-1305	155	3	.6	.6	NUM
dti-1305	155	4	11	11	NUM
dti-1305	155	5	.3	.3	NUM
dti-1305	155	6	ch	ch	PROPN
dti-1305	155	7	ar	ar	PROPN
dti-1305	155	8	ge	ge	PROPN
dti-1305	155	9	tr	tr	VERB
dti-1305	155	10	an	an	DET
dti-1305	155	11	sf	sf	NOUN
dti-1305	155	12	er	er	INTJ
dti-1305	155	13	in	in	ADP
dti-1305	155	14	e	e	PROPN
dti-1305	155	15	h	h	NOUN
dti-1305	155	16	2	2	NUM
dti-1305	156	1	ye	ye	NOUN
dti-1305	156	2	s	s	PART
dti-1305	156	3	ye	ye	PRON
dti-1305	156	4	s	s	NOUN
dti-1305	156	5	ye	ye	PRON
dti-1305	156	6	s	s	NOUN
dti-1305	156	7	ye	ye	PRON
dti-1305	156	8	s	s	NOUN
dti-1305	156	9	ye	ye	PRON
dti-1305	156	10	s	s	NOUN
dti-1305	156	11	ye	ye	NOUN
dti-1305	156	12	s	s	NOUN
dti-1305	156	13	ε	ε	PROPN
dti-1305	156	14	0	0	NUM
dti-1305	156	15	a	a	PRON
dti-1305	156	16	t	t	NOUN
dti-1305	156	17	λ	λ	NOUN
dti-1305	156	18	53	53	NUM
dti-1305	156	19	0	0	NUM
dti-1305	157	1	(	(	PUNCT
dti-1305	157	2	m	m	VERB
dti-1305	157	3	m	m	VERB
dti-1305	157	4	–	–	PUNCT
dti-1305	157	5	1	1	NUM
dti-1305	157	6	cm	cm	NUM
dti-1305	157	7	–	–	PUNCT
dti-1305	157	8	1	1	NUM
dti-1305	157	9	)	)	PUNCT
dti-1305	157	10	3	3	NUM
dti-1305	157	11	.	.	NOUN
dti-1305	157	12	63	63	NUM
dti-1305	157	13	4	4	NUM
dti-1305	157	14	.	.	NOUN
dti-1305	157	15	2	2	NUM
dti-1305	157	16	4	4	NUM
dti-1305	157	17	.	.	NOUN
dti-1305	157	18	9	9	NUM
dti-1305	157	19	3	3	NUM
dti-1305	157	20	.	.	NOUN
dti-1305	157	21	7	7	NUM
dti-1305	157	22	4	4	NUM
dti-1305	157	23	.	.	X
dti-1305	157	24	5	5	NUM
dti-1305	158	1	k	k	NOUN
dti-1305	158	2	m	m	PROPN
dti-1305	158	3	(	(	PUNCT
dti-1305	158	4	µ	µ	X
dti-1305	158	5	m	m	PROPN
dti-1305	158	6	)	)	PUNCT
dti-1305	158	7	t	t	PROPN
dti-1305	158	8	ry	ry	PROPN
dti-1305	159	1	pa	pa	PROPN
dti-1305	159	2	no	no	INTJ
dti-1305	159	3	th	th	X
dti-1305	159	4	io	io	X
dti-1305	159	5	ne	ne	PROPN
dti-1305	159	6	53	53	NUM
dti-1305	159	7	(	(	PUNCT
dti-1305	159	8	5	5	NUM
dti-1305	159	9	1	1	NUM
dti-1305	159	10	,	,	PUNCT
dti-1305	159	11	5	5	NUM
dti-1305	159	12	8)	8)	NUM
dti-1305	159	13	36	36	NUM
dti-1305	159	14	45	45	NUM
dti-1305	159	15	(	(	PUNCT
dti-1305	159	16	5	5	NUM
dti-1305	159	17	5	5	NUM
dti-1305	159	18	,	,	PUNCT
dti-1305	159	19	5	5	NUM
dti-1305	159	20	0	0	NUM
dti-1305	159	21	)	)	PUNCT
dti-1305	159	22	31	31	NUM
dti-1305	159	23	(	(	PUNCT
dti-1305	159	24	1	1	NUM
dti-1305	159	25	8)	8)	NUM
dti-1305	159	26	20	20	NUM
dti-1305	159	27	00	00	NUM
dti-1305	160	1	g	g	NOUN
dti-1305	160	2	lu	lu	NOUN
dti-1305	160	3	ta	ta	X
dti-1305	160	4	th	th	X
dti-1305	161	1	io	io	X
dti-1305	161	2	ne	ne	PROPN
dti-1305	161	3	66	66	NUM
dti-1305	161	4	(	(	PUNCT
dti-1305	161	5	6	6	NUM
dti-1305	161	6	1	1	NUM
dti-1305	161	7	,	,	PUNCT
dti-1305	161	8	7	7	NUM
dti-1305	161	9	0	0	NUM
dti-1305	161	10	)	)	PUNCT
dti-1305	161	11	65	65	NUM
dti-1305	162	1	k	k	NOUN
dti-1305	162	2	c	c	PROPN
dti-1305	162	3	at	at	ADP
dti-1305	162	4	(	(	PUNCT
dti-1305	162	5	m	m	VERB
dti-1305	162	6	in	in	ADP
dti-1305	162	7	–	–	PUNCT
dti-1305	162	8	1	1	NUM
dti-1305	162	9	)	)	PUNCT
dti-1305	162	10	t	t	PROPN
dti-1305	162	11	ry	ry	NOUN
dti-1305	163	1	pa	pa	PROPN
dti-1305	163	2	no	no	INTJ
dti-1305	163	3	th	th	X
dti-1305	163	4	io	io	X
dti-1305	163	5	ne	ne	ADP
dti-1305	163	6	31	31	NUM
dti-1305	163	7	00	00	NUM
dti-1305	163	8	0	0	NUM
dti-1305	164	1	(	(	PUNCT
dti-1305	164	2	2	2	NUM
dti-1305	164	3	86	86	NUM
dti-1305	164	4	00	00	NUM
dti-1305	164	5	0	0	NUM
dti-1305	164	6	)	)	PUNCT
dti-1305	164	7	10	10	NUM
dti-1305	164	8	76	76	NUM
dti-1305	164	9	0	0	NUM
dti-1305	164	10	14	14	NUM
dti-1305	164	11	29	29	NUM
dti-1305	164	12	9	9	NUM
dti-1305	164	13	96	96	NUM
dti-1305	164	14	00	00	NUM
dti-1305	164	15	61	61	NUM
dti-1305	164	16	00	00	NUM
dti-1305	164	17	9	9	NUM
dti-1305	164	18	.	.	NOUN
dti-1305	164	19	6	6	NUM
dti-1305	164	20	gl	gl	X
dti-1305	164	21	ut	ut	PROPN
dti-1305	164	22	at	at	ADP
dti-1305	164	23	hi	hi	ADV
dti-1305	164	24	on	on	ADP
dti-1305	164	25	e	e	PROPN
dti-1305	164	26	3	3	NUM
dti-1305	164	27	.	.	NOUN
dti-1305	164	28	1	1	NUM
dti-1305	164	29	<	<	X
dti-1305	164	30	2	2	NUM
dti-1305	164	31	44	44	NUM
dti-1305	164	32	00	00	NUM
dti-1305	164	33	0	0	NUM
dti-1305	164	34	12	12	NUM
dti-1305	164	35	60	60	NUM
dti-1305	164	36	0	0	NUM
dti-1305	165	1	k	k	PROPN
dti-1305	165	2	c	c	NOUN
dti-1305	165	3	at	at	ADP
dti-1305	165	4	/k	/k	PROPN
dti-1305	165	5	m	m	PROPN
dti-1305	165	6	(	(	PUNCT
dti-1305	165	7	m	m	PROPN
dti-1305	165	8	–	–	PUNCT
dti-1305	165	9	1	1	NUM
dti-1305	165	10	se	se	X
dti-1305	165	11	c–1	c–1	NOUN
dti-1305	165	12	)	)	PUNCT
dti-1305	166	1	9	9	NUM
dti-1305	166	2	.	.	SYM
dti-1305	166	3	8	8	NUM
dti-1305	166	4	x	x	SYM
dti-1305	166	5	10	10	NUM
dti-1305	166	6	6	6	NUM
dti-1305	166	7	5	5	NUM
dti-1305	166	8	.	.	NOUN
dti-1305	166	9	0	0	NUM
dti-1305	167	1	x	x	SYM
dti-1305	167	2	10	10	NUM
dti-1305	167	3	6	6	NUM
dti-1305	167	4	5	5	NUM
dti-1305	167	5	.	.	SYM
dti-1305	167	6	3	3	NUM
dti-1305	167	7	x	x	SYM
dti-1305	167	8	10	10	NUM
dti-1305	167	9	6	6	NUM
dti-1305	167	10	5	5	NUM
dti-1305	167	11	.	.	SYM
dti-1305	167	12	2	2	NUM
dti-1305	167	13	x	x	SYM
dti-1305	167	14	10	10	NUM
dti-1305	167	15	6	6	NUM
dti-1305	167	16	6	6	NUM
dti-1305	167	17	.	.	SYM
dti-1305	167	18	2	2	NUM
dti-1305	167	19	x	x	SYM
dti-1305	167	20	10	10	NUM
dti-1305	167	21	6	6	NUM
dti-1305	167	22	3	3	NUM
dti-1305	167	23	.	.	NOUN
dti-1305	167	24	1	1	NUM
dti-1305	167	25	x	x	SYM
dti-1305	167	26	10	10	NUM
dti-1305	167	27	6	6	NUM
dti-1305	167	28	k	k	NOUN
dti-1305	167	29	m	m	VERB
dti-1305	167	30	ap	ap	PROPN
dti-1305	167	31	p	p	X
dti-1305	167	32	(	(	PUNCT
dti-1305	167	33	n	n	ADP
dti-1305	167	34	a	a	NOUN
dti-1305	167	35	d	d	X
dti-1305	167	36	p	p	X
dti-1305	167	37	h	h	NOUN
dti-1305	167	38	)	)	PUNCT
dti-1305	167	39	7	7	NUM
dti-1305	167	40	9	9	NUM
dti-1305	167	41	5	5	NUM
dti-1305	167	42	5	5	NUM
dti-1305	167	43	16	16	NUM
dti-1305	167	44	(	(	PUNCT
dti-1305	167	45	2	2	NUM
dti-1305	167	46	5	5	NUM
dti-1305	167	47	)	)	PUNCT
dti-1305	167	48	9	9	NUM
dti-1305	167	49	drug	drug	NOUN
dti-1305	167	50	target	target	NOUN
dti-1305	167	51	insights	insight	NOUN
dti-1305	167	52	2007	2007	NUM
dti-1305	167	53	:	:	PUNCT
dti-1305	167	54	2	2	NUM
dti-1305	167	55	136	136	NUM
dti-1305	167	56	khan	khan	NOUN
dti-1305	167	57	in	in	ADP
dti-1305	167	58	the	the	DET
dti-1305	167	59	fad	fad	NOUN
dti-1305	167	60	domains	domain	NOUN
dti-1305	167	61	(	(	PUNCT
dti-1305	167	62	kuriyan	kuriyan	NOUN
dti-1305	167	63	et	et	PROPN
dti-1305	167	64	al	al	PROPN
dti-1305	167	65	.	.	PROPN
dti-1305	167	66	1991	1991	NUM
dti-1305	167	67	)	)	PUNCT
dti-1305	167	68	.	.	PUNCT
dti-1305	168	1	the	the	DET
dti-1305	168	2	tr	tr	PUNCT
dti-1305	168	3	active	active	ADJ
dti-1305	168	4	site	site	NOUN
dti-1305	168	5	is	be	AUX
dti-1305	168	6	more	more	ADV
dti-1305	168	7	hydrophobic	hydrophobic	ADJ
dti-1305	168	8	and	and	CCONJ
dti-1305	168	9	has	have	VERB
dti-1305	168	10	an	an	DET
dti-1305	168	11	overall	overall	ADJ
dti-1305	168	12	negative	negative	ADJ
dti-1305	168	13	charge	charge	NOUN
dti-1305	168	14	to	to	PART
dti-1305	168	15	attract	attract	VERB
dti-1305	168	16	its	its	PRON
dti-1305	168	17	positively	positively	ADV
dti-1305	168	18	charged	charge	VERB
dti-1305	168	19	and	and	CCONJ
dti-1305	168	20	more	more	ADV
dti-1305	168	21	hydrophobic	hydrophobic	NOUN
dti-1305	168	22	polyamine	polyamine	NOUN
dti-1305	168	23	containing	contain	VERB
dti-1305	168	24	cognate	cognate	NOUN
dti-1305	168	25	substrate	substrate	NOUN
dti-1305	168	26	trypanothione	trypanothione	NOUN
dti-1305	168	27	and	and	CCONJ
dti-1305	168	28	repel	repel	VERB
dti-1305	168	29	the	the	DET
dti-1305	168	30	negatively	negatively	ADV
dti-1305	168	31	charged	charge	VERB
dti-1305	168	32	smaller	small	ADJ
dti-1305	168	33	host	host	NOUN
dti-1305	168	34	substrate	substrate	NOUN
dti-1305	168	35	glutathione	glutathione	NOUN
dti-1305	168	36	.	.	PUNCT
dti-1305	169	1	conversely	conversely	ADV
dti-1305	169	2	,	,	PUNCT
dti-1305	169	3	the	the	DET
dti-1305	169	4	gr	gr	ADP
dti-1305	169	5	active	active	ADJ
dti-1305	169	6	site	site	NOUN
dti-1305	169	7	is	be	AUX
dti-1305	169	8	smaller	small	ADJ
dti-1305	169	9	and	and	CCONJ
dti-1305	169	10	positively	positively	ADV
dti-1305	169	11	charged	charge	VERB
dti-1305	169	12	,	,	PUNCT
dti-1305	169	13	repelling	repel	VERB
dti-1305	169	14	the	the	DET
dti-1305	169	15	larger	large	ADJ
dti-1305	169	16	and	and	CCONJ
dti-1305	169	17	positively	positively	ADV
dti-1305	169	18	charged	charge	VERB
dti-1305	169	19	trypanothione	trypanothione	NOUN
dti-1305	169	20	.	.	PUNCT
dti-1305	170	1	the	the	DET
dti-1305	170	2	x	x	NOUN
dti-1305	170	3	-	-	NOUN
dti-1305	170	4	ray	ray	NOUN
dti-1305	170	5	crystal	crystal	NOUN
dti-1305	170	6	structures	structure	NOUN
dti-1305	170	7	of	of	ADP
dti-1305	170	8	trs	trs	PROPN
dti-1305	170	9	from	from	ADP
dti-1305	170	10	crithedia	crithedia	NOUN
dti-1305	170	11	fasciculata	fasciculata	PROPN
dti-1305	170	12	(	(	PUNCT
dti-1305	170	13	kuriyan	kuriyan	PROPN
dti-1305	170	14	et	et	PROPN
dti-1305	170	15	al	al	PROPN
dti-1305	170	16	.	.	PROPN
dti-1305	170	17	1991	1991	NUM
dti-1305	170	18	;	;	PUNCT
dti-1305	170	19	hunter	hunter	NOUN
dti-1305	170	20	et	et	PROPN
dti-1305	170	21	al	al	PROPN
dti-1305	170	22	.	.	PROPN
dti-1305	170	23	1992	1992	NUM
dti-1305	170	24	)	)	PUNCT
dti-1305	170	25	,	,	PUNCT
dti-1305	170	26	and	and	CCONJ
dti-1305	170	27	t.	t.	PROPN
dti-1305	170	28	cruzi	cruzi	PROPN
dti-1305	170	29	have	have	AUX
dti-1305	170	30	been	be	AUX
dti-1305	170	31	solved	solve	VERB
dti-1305	170	32	(	(	PUNCT
dti-1305	170	33	lantwin	lantwin	PROPN
dti-1305	170	34	et	et	PROPN
dti-1305	170	35	al	al	PROPN
dti-1305	170	36	.	.	PROPN
dti-1305	170	37	1994	1994	NUM
dti-1305	170	38	;	;	PUNCT
dti-1305	170	39	zhang	zhang	PROPN
dti-1305	170	40	et	et	PROPN
dti-1305	170	41	al	al	PROPN
dti-1305	170	42	.	.	PROPN
dti-1305	170	43	1996	1996	NUM
dti-1305	170	44	)	)	PUNCT
dti-1305	170	45	.	.	PUNCT
dti-1305	171	1	the	the	DET
dti-1305	171	2	crystal	crystal	NOUN
dti-1305	171	3	structure	structure	NOUN
dti-1305	171	4	of	of	ADP
dti-1305	171	5	tr	tr	VERB
dti-1305	171	6	in	in	ADP
dti-1305	171	7	complex	complex	NOUN
dti-1305	171	8	with	with	ADP
dti-1305	171	9	trypanothione	trypanothione	NOUN
dti-1305	171	10	was	be	AUX
dti-1305	171	11	solved	solve	VERB
dti-1305	171	12	(	(	PUNCT
dti-1305	171	13	bond	bond	NOUN
dti-1305	171	14	et	et	PROPN
dti-1305	171	15	al	al	PROPN
dti-1305	171	16	.	.	PROPN
dti-1305	171	17	1999	1999	NUM
dti-1305	171	18	)	)	PUNCT
dti-1305	171	19	as	as	SCONJ
dti-1305	171	20	was	be	AUX
dti-1305	171	21	the	the	DET
dti-1305	171	22	crystal	crystal	NOUN
dti-1305	171	23	structure	structure	NOUN
dti-1305	171	24	of	of	ADP
dti-1305	171	25	tr	tr	VERB
dti-1305	171	26	complexed	complexe	VERB
dti-1305	171	27	with	with	ADP
dti-1305	171	28	the	the	DET
dti-1305	171	29	alternative	alternative	ADJ
dti-1305	171	30	substrate	substrate	NOUN
dti-1305	171	31	glutathionyl	glutathionyl	NOUN
dti-1305	171	32	spermidine	spermidine	NOUN
dti-1305	171	33	(	(	PUNCT
dti-1305	171	34	bailey	bailey	PROPN
dti-1305	171	35	et	et	PROPN
dti-1305	171	36	al	al	PROPN
dti-1305	171	37	.	.	PROPN
dti-1305	171	38	1993	1993	NUM
dti-1305	171	39	)	)	PUNCT
dti-1305	171	40	and	and	CCONJ
dti-1305	171	41	with	with	ADP
dti-1305	171	42	the	the	DET
dti-1305	171	43	weak	weak	ADJ
dti-1305	171	44	,	,	PUNCT
dti-1305	171	45	but	but	CCONJ
dti-1305	171	46	selective	selective	ADJ
dti-1305	171	47	,	,	PUNCT
dti-1305	171	48	inhibitor	inhibitor	NOUN
dti-1305	171	49	mepacrine	mepacrine	NOUN
dti-1305	171	50	(	(	PUNCT
dti-1305	171	51	jacoby	jacoby	PROPN
dti-1305	171	52	et	et	PROPN
dti-1305	171	53	al	al	PROPN
dti-1305	171	54	.	.	PROPN
dti-1305	171	55	1996	1996	NUM
dti-1305	171	56	)	)	PUNCT
dti-1305	171	57	.	.	PUNCT
dti-1305	172	1	as	as	SCONJ
dti-1305	172	2	already	already	ADV
dti-1305	172	3	pointed	point	VERB
dti-1305	172	4	out	out	ADP
dti-1305	172	5	,	,	PUNCT
dti-1305	172	6	a	a	DET
dti-1305	172	7	convenient	convenient	ADJ
dti-1305	172	8	screening	screening	NOUN
dti-1305	172	9	technology	technology	NOUN
dti-1305	172	10	is	be	AUX
dti-1305	172	11	highly	highly	ADV
dti-1305	172	12	desirable	desirable	ADJ
dti-1305	172	13	for	for	ADP
dti-1305	172	14	a	a	DET
dti-1305	172	15	suitable	suitable	ADJ
dti-1305	172	16	substrate	substrate	NOUN
dti-1305	172	17	to	to	PART
dti-1305	172	18	expedite	expedite	VERB
dti-1305	172	19	the	the	DET
dti-1305	172	20	drug	drug	NOUN
dti-1305	172	21	discovery	discovery	NOUN
dti-1305	172	22	process	process	NOUN
dti-1305	172	23	.	.	PUNCT
dti-1305	173	1	to	to	ADP
dti-1305	173	2	this	this	DET
dti-1305	173	3	end	end	NOUN
dti-1305	173	4	,	,	PUNCT
dti-1305	173	5	a	a	DET
dti-1305	173	6	convenient	convenient	ADJ
dti-1305	173	7	colorimetric	colorimetric	ADJ
dti-1305	173	8	plate	plate	NOUN
dti-1305	173	9	assay	assay	VERB
dti-1305	173	10	suitable	suitable	ADJ
dti-1305	173	11	for	for	ADP
dti-1305	173	12	automated	automate	VERB
dti-1305	173	13	highthroughput	highthroughput	NOUN
dti-1305	173	14	screening	screening	NOUN
dti-1305	173	15	has	have	AUX
dti-1305	173	16	been	be	AUX
dti-1305	173	17	developed	develop	VERB
dti-1305	173	18	by	by	ADP
dti-1305	173	19	hamilton	hamilton	PROPN
dti-1305	173	20	et	et	PROPN
dti-1305	173	21	al	al	PROPN
dti-1305	173	22	.	.	PROPN
dti-1305	174	1	(	(	PUNCT
dti-1305	174	2	2003	2003	NUM
dti-1305	174	3	)	)	PUNCT
dti-1305	174	4	.	.	PUNCT
dti-1305	175	1	one	one	NUM
dti-1305	175	2	disadvantage	disadvantage	NOUN
dti-1305	175	3	of	of	ADP
dti-1305	175	4	selecting	selecting	NOUN
dti-1305	175	5	tr	tr	VERB
dti-1305	175	6	as	as	ADP
dti-1305	175	7	a	a	DET
dti-1305	175	8	drug	drug	NOUN
dti-1305	175	9	target	target	NOUN
dti-1305	175	10	for	for	ADP
dti-1305	175	11	the	the	DET
dti-1305	175	12	development	development	NOUN
dti-1305	175	13	of	of	ADP
dti-1305	175	14	broad	broad	ADJ
dti-1305	175	15	-	-	PUNCT
dti-1305	175	16	spectrum	spectrum	NOUN
dti-1305	175	17	antiparasitics	antiparasitic	NOUN
dti-1305	175	18	is	be	AUX
dti-1305	175	19	that	that	SCONJ
dti-1305	175	20	intracellular	intracellular	ADJ
dti-1305	175	21	trypanothione	trypanothione	NOUN
dti-1305	175	22	concentrations	concentration	NOUN
dti-1305	175	23	vary	vary	VERB
dti-1305	175	24	from	from	ADP
dti-1305	175	25	0.3	0.3	NUM
dti-1305	175	26	mm	mm	NOUN
dti-1305	175	27	in	in	ADP
dti-1305	175	28	african	african	ADJ
dti-1305	175	29	trypanosomes	trypanosome	NOUN
dti-1305	175	30	to	to	ADP
dti-1305	175	31	~3.0	~3.0	PROPN
dti-1305	175	32	mm	mm	PROPN
dti-1305	175	33	in	in	ADP
dti-1305	175	34	leishmania	leishmania	NOUN
dti-1305	175	35	spp	spp	PROPN
dti-1305	175	36	.	.	PROPN
dti-1305	175	37	,	,	PUNCT
dti-1305	175	38	>	>	PUNCT
dti-1305	175	39	99	99	NUM
dti-1305	175	40	%	%	NOUN
dti-1305	175	41	of	of	ADP
dti-1305	175	42	which	which	PRON
dti-1305	175	43	is	be	AUX
dti-1305	175	44	in	in	ADP
dti-1305	175	45	the	the	DET
dti-1305	175	46	reduced	reduce	VERB
dti-1305	175	47	form	form	NOUN
dti-1305	175	48	.	.	PUNCT
dti-1305	176	1	as	as	ADV
dti-1305	176	2	soon	soon	ADV
dti-1305	176	3	as	as	SCONJ
dti-1305	176	4	tr	tr	NOUN
dti-1305	176	5	is	be	AUX
dti-1305	176	6	inhibited	inhibit	VERB
dti-1305	176	7	,	,	PUNCT
dti-1305	176	8	t[s]2	t[s]2	NOUN
dti-1305	176	9	will	will	AUX
dti-1305	176	10	start	start	VERB
dti-1305	176	11	to	to	PART
dti-1305	176	12	accumulate	accumulate	VERB
dti-1305	176	13	due	due	ADJ
dti-1305	176	14	to	to	ADP
dti-1305	176	15	continuing	continue	VERB
dti-1305	176	16	intracellular	intracellular	ADJ
dti-1305	176	17	oxidant	oxidant	ADJ
dti-1305	176	18	process	process	NOUN
dti-1305	176	19	.	.	PUNCT
dti-1305	177	1	it	it	PRON
dti-1305	177	2	is	be	AUX
dti-1305	177	3	not	not	PART
dti-1305	177	4	currently	currently	ADV
dti-1305	177	5	known	know	VERB
dti-1305	177	6	what	what	PRON
dti-1305	177	7	t[s]2	t[s]2	NOUN
dti-1305	177	8	/	/	SYM
dti-1305	177	9	t[sh]2	t[sh]2	PROPN
dti-1305	177	10	ratio	ratio	NOUN
dti-1305	177	11	is	be	AUX
dti-1305	177	12	lethal	lethal	ADJ
dti-1305	177	13	to	to	ADP
dti-1305	177	14	the	the	DET
dti-1305	177	15	parasite	parasite	NOUN
dti-1305	177	16	.	.	PUNCT
dti-1305	178	1	it	it	PRON
dti-1305	178	2	has	have	AUX
dti-1305	178	3	been	be	AUX
dti-1305	178	4	suggested	suggest	VERB
dti-1305	178	5	that	that	SCONJ
dti-1305	178	6	the	the	DET
dti-1305	178	7	design	design	NOUN
dti-1305	178	8	of	of	ADP
dti-1305	178	9	competitive	competitive	ADJ
dti-1305	178	10	inhibitors	inhibitor	NOUN
dti-1305	178	11	with	with	ADP
dti-1305	178	12	ki	ki	NOUN
dti-1305	178	13	-	-	PUNCT
dti-1305	178	14	values	value	NOUN
dti-1305	178	15	in	in	ADP
dti-1305	178	16	nm	nm	ADJ
dti-1305	178	17	range	range	NOUN
dti-1305	178	18	will	will	AUX
dti-1305	178	19	be	be	AUX
dti-1305	178	20	required	require	VERB
dti-1305	178	21	,	,	PUNCT
dti-1305	178	22	and	and	CCONJ
dti-1305	178	23	the	the	DET
dti-1305	178	24	design	design	NOUN
dti-1305	178	25	of	of	ADP
dti-1305	178	26	irreversible	irreversible	ADJ
dti-1305	178	27	inhibitors	inhibitor	NOUN
dti-1305	178	28	may	may	AUX
dti-1305	178	29	represent	represent	VERB
dti-1305	178	30	a	a	DET
dti-1305	178	31	better	well	ADJ
dti-1305	178	32	strategy	strategy	NOUN
dti-1305	178	33	for	for	ADP
dti-1305	178	34	drug	drug	NOUN
dti-1305	178	35	development	development	NOUN
dti-1305	178	36	(	(	PUNCT
dti-1305	178	37	fairlamb	fairlamb	PROPN
dti-1305	178	38	,	,	PUNCT
dti-1305	178	39	2003b	2003b	NUM
dti-1305	178	40	)	)	PUNCT
dti-1305	178	41	.	.	PUNCT
dti-1305	179	1	the	the	DET
dti-1305	179	2	following	follow	VERB
dti-1305	179	3	section	section	NOUN
dti-1305	179	4	will	will	AUX
dti-1305	179	5	focus	focus	VERB
dti-1305	179	6	on	on	ADP
dti-1305	179	7	recent	recent	ADJ
dti-1305	179	8	discoveries	discovery	NOUN
dti-1305	179	9	of	of	ADP
dti-1305	179	10	different	different	ADJ
dti-1305	179	11	classes	class	NOUN
dti-1305	179	12	of	of	ADP
dti-1305	179	13	tr	tr	VERB
dti-1305	179	14	inhibitors	inhibitor	NOUN
dti-1305	179	15	,	,	PUNCT
dti-1305	179	16	which	which	PRON
dti-1305	179	17	demonstrated	demonstrate	VERB
dti-1305	179	18	antiparasitic	antiparasitic	ADJ
dti-1305	179	19	activity	activity	NOUN
dti-1305	179	20	and	and	CCONJ
dti-1305	179	21	promise	promise	NOUN
dti-1305	179	22	of	of	ADP
dti-1305	179	23	development	development	NOUN
dti-1305	179	24	of	of	ADP
dti-1305	179	25	newer	new	ADJ
dti-1305	179	26	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	179	27	agents	agent	NOUN
dti-1305	179	28	.	.	PUNCT
dti-1305	180	1	rational	rational	ADJ
dti-1305	180	2	drug	drug	NOUN
dti-1305	180	3	design	design	NOUN
dti-1305	180	4	based	base	VERB
dti-1305	180	5	on	on	ADP
dti-1305	180	6	trypanothione	trypanothione	PROPN
dti-1305	180	7	reductase	reductase	NOUN
dti-1305	180	8	as	as	ADP
dti-1305	180	9	a	a	DET
dti-1305	180	10	target	target	NOUN
dti-1305	180	11	the	the	DET
dti-1305	180	12	homology	homology	NOUN
dti-1305	180	13	modeling	modeling	NOUN
dti-1305	180	14	of	of	ADP
dti-1305	180	15	tr	tr	PUNCT
dti-1305	180	16	(	(	PUNCT
dti-1305	180	17	benson	benson	PROPN
dti-1305	180	18	et	et	PROPN
dti-1305	180	19	al	al	PROPN
dti-1305	180	20	.	.	PROPN
dti-1305	180	21	1992	1992	NUM
dti-1305	180	22	)	)	PUNCT
dti-1305	180	23	with	with	ADP
dti-1305	180	24	that	that	PRON
dti-1305	180	25	of	of	ADP
dti-1305	180	26	hgr	hgr	NOUN
dti-1305	180	27	shed	shed	VERB
dti-1305	180	28	light	light	NOUN
dti-1305	180	29	on	on	ADP
dti-1305	180	30	the	the	DET
dti-1305	180	31	structural	structural	ADJ
dti-1305	180	32	aspects	aspect	NOUN
dti-1305	180	33	of	of	ADP
dti-1305	180	34	the	the	DET
dti-1305	180	35	enzyme	enzyme	NOUN
dti-1305	180	36	also	also	ADV
dti-1305	180	37	in	in	ADP
dti-1305	180	38	addition	addition	NOUN
dti-1305	180	39	to	to	ADP
dti-1305	180	40	its	its	PRON
dti-1305	180	41	substratebinding	substratebinde	VERB
dti-1305	180	42	mode	mode	NOUN
dti-1305	180	43	from	from	ADP
dti-1305	180	44	a	a	DET
dti-1305	180	45	theoretical	theoretical	ADJ
dti-1305	180	46	perspective	perspective	NOUN
dti-1305	180	47	.	.	PUNCT
dti-1305	181	1	studies	study	NOUN
dti-1305	181	2	with	with	ADP
dti-1305	181	3	various	various	ADJ
dti-1305	181	4	alternative	alternative	ADJ
dti-1305	181	5	peptide	peptide	NOUN
dti-1305	181	6	substrates	substrate	NOUN
dti-1305	181	7	demonstrated	demonstrate	VERB
dti-1305	181	8	that	that	SCONJ
dti-1305	181	9	the	the	DET
dti-1305	181	10	spermidine	spermidine	NOUN
dti-1305	181	11	moiety	moiety	NOUN
dti-1305	181	12	of	of	ADP
dti-1305	181	13	trypanothione	trypanothione	NOUN
dti-1305	181	14	could	could	AUX
dti-1305	181	15	be	be	AUX
dti-1305	181	16	conveniently	conveniently	ADV
dti-1305	181	17	replaced	replace	VERB
dti-1305	181	18	with	with	ADP
dti-1305	181	19	n	n	CCONJ
dti-1305	181	20	,	,	PUNCT
dti-1305	181	21	n	n	CCONJ
dti-1305	181	22	-	-	PUNCT
dti-1305	181	23	dimethylaminopropylamide	dimethylaminopropylamide	NOUN
dti-1305	181	24	(	(	PUNCT
dti-1305	181	25	dmapa	dmapa	PROPN
dti-1305	181	26	)	)	PUNCT
dti-1305	181	27	without	without	ADP
dti-1305	181	28	loss	loss	NOUN
dti-1305	181	29	of	of	ADP
dti-1305	181	30	substrate	substrate	NOUN
dti-1305	181	31	activity	activity	NOUN
dti-1305	181	32	.	.	PUNCT
dti-1305	182	1	subsequently	subsequently	ADV
dti-1305	182	2	,	,	PUNCT
dti-1305	182	3	a	a	DET
dti-1305	182	4	series	series	NOUN
dti-1305	182	5	of	of	ADP
dti-1305	182	6	alternative	alternative	ADJ
dti-1305	182	7	γ	γ	PROPN
dti-1305	182	8	-	-	PUNCT
dti-1305	182	9	glutamyl	glutamyl	NOUN
dti-1305	182	10	-	-	PUNCT
dti-1305	182	11	modifi	modifi	NOUN
dti-1305	182	12	ed	ed	PROPN
dti-1305	182	13	trypanothione	trypanothione	NOUN
dti-1305	182	14	substrates	substrate	NOUN
dti-1305	182	15	were	be	AUX
dti-1305	182	16	synthesized	synthesize	VERB
dti-1305	182	17	.	.	PUNCT
dti-1305	183	1	the	the	DET
dti-1305	183	2	discovery	discovery	NOUN
dti-1305	183	3	that	that	PRON
dti-1305	183	4	a	a	DET
dti-1305	183	5	benzyloxycarbonyl	benzyloxycarbonyl	NOUN
dti-1305	183	6	(	(	PUNCT
dti-1305	183	7	z	z	NOUN
dti-1305	183	8	)	)	PUNCT
dti-1305	183	9	group	group	NOUN
dti-1305	183	10	represented	represent	VERB
dti-1305	183	11	a	a	DET
dti-1305	183	12	suitable	suitable	ADJ
dti-1305	183	13	replacement	replacement	NOUN
dti-1305	183	14	resulted	result	VERB
dti-1305	183	15	in	in	ADP
dti-1305	183	16	(	(	PUNCT
dti-1305	183	17	z.cys.gly.dmapa)2	z.cys.gly.dmapa)2	PROPN
dti-1305	183	18	as	as	ADP
dti-1305	183	19	a	a	DET
dti-1305	183	20	convenient	convenient	ADJ
dti-1305	183	21	alternative	alternative	ADJ
dti-1305	183	22	assay	assay	NOUN
dti-1305	183	23	substrate	substrate	NOUN
dti-1305	183	24	in	in	ADP
dti-1305	183	25	which	which	PRON
dti-1305	183	26	the	the	DET
dti-1305	183	27	z	z	PROPN
dti-1305	183	28	group	group	NOUN
dti-1305	183	29	occupies	occupy	VERB
dti-1305	183	30	a	a	DET
dti-1305	183	31	hydrophobic	hydrophobic	NOUN
dti-1305	183	32	pocket	pocket	NOUN
dti-1305	183	33	near	near	ADP
dti-1305	183	34	phe396	phe396	PROPN
dti-1305	183	35	’	'	PUNCT
dti-1305	183	36	of	of	ADP
dti-1305	183	37	tr	tr	ADP
dti-1305	183	38	(	(	PUNCT
dti-1305	183	39	henderson	henderson	PROPN
dti-1305	183	40	et	et	PROPN
dti-1305	183	41	al	al	PROPN
dti-1305	183	42	.	.	PROPN
dti-1305	183	43	1987b	1987b	PROPN
dti-1305	183	44	;	;	PUNCT
dti-1305	183	45	el	el	PROPN
dti-1305	183	46	-	-	PUNCT
dti-1305	183	47	waer	waer	PROPN
dti-1305	183	48	et	et	PROPN
dti-1305	183	49	al	al	PROPN
dti-1305	183	50	.	.	PROPN
dti-1305	183	51	1991	1991	NUM
dti-1305	183	52	,	,	PUNCT
dti-1305	183	53	1993a	1993a	NUM
dti-1305	183	54	and	and	CCONJ
dti-1305	183	55	b	b	NOUN
dti-1305	183	56	;	;	PUNCT
dti-1305	183	57	marsh	marsh	PROPN
dti-1305	183	58	and	and	CCONJ
dti-1305	183	59	bradley	bradley	PROPN
dti-1305	183	60	,	,	PUNCT
dti-1305	183	61	1997	1997	NUM
dti-1305	183	62	)	)	PUNCT
dti-1305	183	63	.	.	PUNCT
dti-1305	184	1	this	this	DET
dti-1305	184	2	pocket	pocket	NOUN
dti-1305	184	3	was	be	AUX
dti-1305	184	4	since	since	SCONJ
dti-1305	184	5	named	name	VERB
dti-1305	184	6	the	the	DET
dti-1305	184	7	z	z	NOUN
dti-1305	184	8	-	-	PUNCT
dti-1305	184	9	site	site	NOUN
dti-1305	184	10	,	,	PUNCT
dti-1305	184	11	approximately	approximately	ADV
dti-1305	184	12	enclosed	enclose	VERB
dti-1305	184	13	by	by	ADP
dti-1305	184	14	phe396	phe396	PROPN
dti-1305	184	15	’	'	PUNCT
dti-1305	184	16	,	,	PUNCT
dti-1305	184	17	pro398	pro398	PROPN
dti-1305	184	18	’	'	PUNCT
dti-1305	184	19	and	and	CCONJ
dti-1305	184	20	leu399	leu399	PROPN
dti-1305	184	21	’	'	PUNCT
dti-1305	184	22	.	.	PUNCT
dti-1305	185	1	this	this	DET
dti-1305	185	2	initial	initial	ADJ
dti-1305	185	3	advancement	advancement	NOUN
dti-1305	185	4	in	in	ADP
dti-1305	185	5	structural	structural	ADJ
dti-1305	185	6	aspects	aspect	NOUN
dti-1305	185	7	of	of	ADP
dti-1305	185	8	tr	tr	PUNCT
dti-1305	185	9	active	active	ADJ
dti-1305	185	10	site	site	NOUN
dti-1305	185	11	prompted	prompt	VERB
dti-1305	185	12	the	the	DET
dti-1305	185	13	discovery	discovery	NOUN
dti-1305	185	14	of	of	ADP
dti-1305	185	15	peptide	peptide	ADJ
dti-1305	185	16	inhibitors	inhibitor	NOUN
dti-1305	185	17	(	(	PUNCT
dti-1305	185	18	garforth	garforth	NOUN
dti-1305	185	19	et	et	PROPN
dti-1305	185	20	al	al	PROPN
dti-1305	185	21	.	.	PROPN
dti-1305	185	22	1994	1994	NUM
dti-1305	185	23	;	;	PUNCT
dti-1305	185	24	mckie	mckie	PROPN
dti-1305	185	25	et	et	PROPN
dti-1305	185	26	al	al	PROPN
dti-1305	185	27	.	.	PROPN
dti-1305	185	28	2001	2001	NUM
dti-1305	185	29	;	;	PUNCT
dti-1305	185	30	chan	chan	PROPN
dti-1305	185	31	et	et	PROPN
dti-1305	185	32	al	al	PROPN
dti-1305	185	33	.	.	PROPN
dti-1305	185	34	2002	2002	NUM
dti-1305	185	35	)	)	PUNCT
dti-1305	185	36	.	.	PUNCT
dti-1305	186	1	the	the	DET
dti-1305	186	2	fi	fi	NOUN
dti-1305	186	3	rst	rst	PROPN
dti-1305	186	4	rationally	rationally	ADV
dti-1305	186	5	designed	design	VERB
dti-1305	186	6	non	non	ADJ
dti-1305	186	7	-	-	ADJ
dti-1305	186	8	peptide	peptide	ADJ
dti-1305	186	9	inhibitors	inhibitor	NOUN
dti-1305	186	10	are	be	AUX
dti-1305	186	11	represented	represent	VERB
dti-1305	186	12	by	by	ADP
dti-1305	186	13	the	the	DET
dti-1305	186	14	tricyclic	tricyclic	ADJ
dti-1305	186	15	ring	ring	NOUN
dti-1305	186	16	structures	structure	NOUN
dti-1305	186	17	that	that	PRON
dti-1305	186	18	are	be	AUX
dti-1305	186	19	competitive	competitive	ADJ
dti-1305	186	20	versus	versus	ADP
dti-1305	186	21	trypanothione	trypanothione	NOUN
dti-1305	186	22	(	(	PUNCT
dti-1305	186	23	benson	benson	PROPN
dti-1305	186	24	et	et	PROPN
dti-1305	186	25	al	al	PROPN
dti-1305	186	26	.	.	PROPN
dti-1305	186	27	1992	1992	NUM
dti-1305	186	28	)	)	PUNCT
dti-1305	186	29	.	.	PUNCT
dti-1305	187	1	progress	progress	NOUN
dti-1305	187	2	has	have	AUX
dti-1305	187	3	been	be	AUX
dti-1305	187	4	made	make	VERB
dti-1305	187	5	in	in	ADP
dti-1305	187	6	discovering	discover	VERB
dti-1305	187	7	large	large	ADJ
dti-1305	187	8	classes	class	NOUN
dti-1305	187	9	of	of	ADP
dti-1305	187	10	inhibitors	inhibitor	NOUN
dti-1305	187	11	of	of	ADP
dti-1305	187	12	tr	tr	VERB
dti-1305	187	13	over	over	ADP
dti-1305	187	14	recent	recent	ADJ
dti-1305	187	15	years	year	NOUN
dti-1305	187	16	,	,	PUNCT
dti-1305	187	17	which	which	PRON
dti-1305	187	18	are	be	AUX
dti-1305	187	19	also	also	ADV
dti-1305	187	20	found	find	VERB
dti-1305	187	21	to	to	PART
dti-1305	187	22	be	be	AUX
dti-1305	187	23	lethal	lethal	ADJ
dti-1305	187	24	to	to	ADP
dti-1305	187	25	parasites	parasite	NOUN
dti-1305	187	26	in	in	ADP
dti-1305	187	27	vitro	vitro	VERB
dti-1305	187	28	.	.	PUNCT
dti-1305	188	1	the	the	DET
dti-1305	188	2	tricyclic	tricyclic	ADJ
dti-1305	188	3	compounds	compound	NOUN
dti-1305	188	4	and	and	CCONJ
dti-1305	188	5	congeners	congener	NOUN
dti-1305	188	6	molecular	molecular	ADJ
dti-1305	188	7	modeling	modeling	NOUN
dti-1305	188	8	approaches	approach	NOUN
dti-1305	188	9	were	be	AUX
dti-1305	188	10	useful	useful	ADJ
dti-1305	188	11	in	in	ADP
dti-1305	188	12	identifying	identify	VERB
dti-1305	188	13	tricyclic	tricyclic	ADJ
dti-1305	188	14	antidepressants	antidepressant	NOUN
dti-1305	188	15	including	include	VERB
dti-1305	188	16	phenothiazines	phenothiazine	NOUN
dti-1305	188	17	and	and	CCONJ
dti-1305	188	18	related	related	ADJ
dti-1305	188	19	structures	structure	NOUN
dti-1305	188	20	(	(	PUNCT
dti-1305	188	21	e.g.	e.g.	ADV
dti-1305	188	22	9	9	NUM
dti-1305	188	23	,	,	PUNCT
dti-1305	188	24	10	10	NUM
dti-1305	188	25	)	)	PUNCT
dti-1305	188	26	and	and	CCONJ
dti-1305	188	27	mepacrine	mepacrine	NOUN
dti-1305	188	28	(	(	PUNCT
dti-1305	188	29	11	11	NUM
dti-1305	188	30	)	)	PUNCT
dti-1305	188	31	(	(	PUNCT
dti-1305	188	32	fig	fig	NOUN
dti-1305	188	33	.	.	PUNCT
dti-1305	189	1	5	5	NUM
dti-1305	189	2	)	)	PUNCT
dti-1305	189	3	as	as	ADP
dti-1305	189	4	competitive	competitive	ADJ
dti-1305	189	5	inhibitors	inhibitor	NOUN
dti-1305	189	6	of	of	ADP
dti-1305	189	7	tr	tr	VERB
dti-1305	189	8	but	but	CCONJ
dti-1305	189	9	not	not	PART
dti-1305	189	10	gr	gr	PRON
dti-1305	189	11	(	(	PUNCT
dti-1305	189	12	benson	benson	PROPN
dti-1305	189	13	et	et	PROPN
dti-1305	189	14	al	al	PROPN
dti-1305	189	15	.	.	PROPN
dti-1305	189	16	1992	1992	NUM
dti-1305	189	17	;	;	PUNCT
dti-1305	189	18	jacoby	jacoby	PROPN
dti-1305	189	19	et	et	PROPN
dti-1305	189	20	al	al	PROPN
dti-1305	189	21	.	.	PROPN
dti-1305	189	22	1996	1996	NUM
dti-1305	189	23	;	;	PUNCT
dti-1305	189	24	chan	chan	PROPN
dti-1305	189	25	et	et	PROPN
dti-1305	189	26	al	al	PROPN
dti-1305	189	27	.	.	PROPN
dti-1305	189	28	1998	1998	NUM
dti-1305	189	29	)	)	PUNCT
dti-1305	189	30	.	.	PUNCT
dti-1305	190	1	the	the	DET
dti-1305	190	2	tricyclic	tricyclic	ADJ
dti-1305	190	3	moiety	moiety	NOUN
dti-1305	190	4	of	of	ADP
dti-1305	190	5	these	these	DET
dti-1305	190	6	compounds	compound	NOUN
dti-1305	190	7	were	be	AUX
dti-1305	190	8	shown	show	VERB
dti-1305	190	9	to	to	PART
dti-1305	190	10	lodge	lodge	VERB
dti-1305	190	11	against	against	ADP
dti-1305	190	12	the	the	DET
dti-1305	190	13	hydrophobic	hydrophobic	NOUN
dti-1305	190	14	wall	wall	NOUN
dti-1305	190	15	of	of	ADP
dti-1305	190	16	tr	tr	PUNCT
dti-1305	190	17	active	active	ADJ
dti-1305	190	18	site	site	NOUN
dti-1305	190	19	formed	form	VERB
dti-1305	190	20	by	by	ADP
dti-1305	190	21	trp21	trp21	NOUN
dti-1305	190	22	and	and	CCONJ
dti-1305	190	23	met113	met113	PROPN
dti-1305	190	24	,	,	PUNCT
dti-1305	190	25	with	with	ADP
dti-1305	190	26	the	the	DET
dti-1305	190	27	aminopropyl	aminopropyl	ADJ
dti-1305	190	28	side	side	NOUN
dti-1305	190	29	chain	chain	NOUN
dti-1305	190	30	pointing	pointing	NOUN
dti-1305	190	31	towards	towards	ADP
dti-1305	190	32	the	the	DET
dti-1305	190	33	glu466	glu466	NOUN
dti-1305	190	34	’	'	PUNCT
dti-1305	190	35	and	and	CCONJ
dti-1305	190	36	glu467	glu467	NOUN
dti-1305	190	37	’	'	PUNCT
dti-1305	190	38	residues	residue	NOUN
dti-1305	190	39	.	.	PUNCT
dti-1305	191	1	the	the	DET
dti-1305	191	2	synthesis	synthesis	NOUN
dti-1305	191	3	and	and	CCONJ
dti-1305	191	4	biological	biological	ADJ
dti-1305	191	5	evaluation	evaluation	NOUN
dti-1305	191	6	of	of	ADP
dti-1305	191	7	a	a	DET
dti-1305	191	8	series	series	NOUN
dti-1305	191	9	of	of	ADP
dti-1305	191	10	dibenzazepine	dibenzazepine	NOUN
dti-1305	191	11	analogs	analog	NOUN
dti-1305	191	12	(	(	PUNCT
dti-1305	191	13	garforth	garforth	NOUN
dti-1305	191	14	et	et	PROPN
dti-1305	191	15	al	al	PROPN
dti-1305	191	16	.	.	PROPN
dti-1305	191	17	1997	1997	NUM
dti-1305	191	18	)	)	PUNCT
dti-1305	191	19	,	,	PUNCT
dti-1305	191	20	n	n	CCONJ
dti-1305	191	21	-	-	PUNCT
dti-1305	191	22	acylpromazines	acylpromazine	NOUN
dti-1305	191	23	,	,	PUNCT
dti-1305	191	24	2	2	NUM
dti-1305	191	25	-	-	PUNCT
dti-1305	191	26	substituted	substitute	VERB
dti-1305	191	27	phenothiazines	phenothiazine	NOUN
dti-1305	191	28	,	,	PUNCT
dti-1305	191	29	and	and	CCONJ
dti-1305	191	30	trisubstituted	trisubstitute	VERB
dti-1305	191	31	promazines	promazine	NOUN
dti-1305	191	32	failed	fail	VERB
dti-1305	191	33	to	to	PART
dti-1305	191	34	show	show	VERB
dti-1305	191	35	any	any	DET
dti-1305	191	36	improvements	improvement	NOUN
dti-1305	191	37	over	over	ADP
dti-1305	191	38	the	the	DET
dti-1305	191	39	parent	parent	NOUN
dti-1305	191	40	leads	lead	VERB
dti-1305	191	41	(	(	PUNCT
dti-1305	191	42	chan	chan	PROPN
dti-1305	191	43	et	et	PROPN
dti-1305	191	44	al	al	PROPN
dti-1305	191	45	.	.	PROPN
dti-1305	191	46	1998	1998	NUM
dti-1305	191	47	)	)	PUNCT
dti-1305	191	48	.	.	PUNCT
dti-1305	192	1	the	the	DET
dti-1305	192	2	antimalarial	antimalarial	ADJ
dti-1305	192	3	drug	drug	NOUN
dti-1305	192	4	mepacrine	mepacrine	NOUN
dti-1305	192	5	(	(	PUNCT
dti-1305	192	6	11	11	NUM
dti-1305	192	7	)	)	PUNCT
dti-1305	192	8	,	,	PUNCT
dti-1305	192	9	an	an	DET
dti-1305	192	10	acridine	acridine	NOUN
dti-1305	192	11	derivative	derivative	NOUN
dti-1305	192	12	,	,	PUNCT
dti-1305	192	13	is	be	AUX
dti-1305	192	14	also	also	ADV
dti-1305	192	15	a	a	DET
dti-1305	192	16	competitive	competitive	ADJ
dti-1305	192	17	inhibitor	inhibitor	NOUN
dti-1305	192	18	of	of	ADP
dti-1305	192	19	tr	tr	VERB
dti-1305	192	20	.	.	PUNCT
dti-1305	193	1	the	the	DET
dti-1305	193	2	acridine	acridine	PROPN
dti-1305	193	3	ring	ring	NOUN
dti-1305	193	4	also	also	ADV
dti-1305	193	5	aligns	align	VERB
dti-1305	193	6	to	to	ADP
dti-1305	193	7	the	the	DET
dti-1305	193	8	hydrophobic	hydrophobic	NOUN
dti-1305	193	9	wall	wall	NOUN
dti-1305	193	10	of	of	ADP
dti-1305	193	11	tr	tr	AUX
dti-1305	193	12	formed	form	VERB
dti-1305	193	13	by	by	ADP
dti-1305	193	14	trp21	trp21	NOUN
dti-1305	193	15	and	and	CCONJ
dti-1305	193	16	met113	met113	PROPN
dti-1305	193	17	,	,	PUNCT
dti-1305	193	18	but	but	CCONJ
dti-1305	193	19	the	the	DET
dti-1305	193	20	alkylamino	alkylamino	PROPN
dti-1305	193	21	side	side	NOUN
dti-1305	193	22	chain	chain	NOUN
dti-1305	193	23	point	point	NOUN
dti-1305	193	24	towards	towards	ADP
dti-1305	193	25	glu18	glu18	NOUN
dti-1305	193	26	,	,	PUNCT
dti-1305	193	27	unlike	unlike	ADP
dti-1305	193	28	the	the	DET
dti-1305	193	29	tricyclics	tricyclic	NOUN
dti-1305	193	30	described	describe	VERB
dti-1305	193	31	above	above	ADV
dti-1305	193	32	(	(	PUNCT
dti-1305	193	33	bonse	bonse	NOUN
dti-1305	193	34	et	et	PROPN
dti-1305	193	35	al	al	PROPN
dti-1305	193	36	.	.	PROPN
dti-1305	193	37	1999	1999	NUM
dti-1305	193	38	)	)	PUNCT
dti-1305	193	39	.	.	PUNCT
dti-1305	194	1	sulfonamides	sulfonamide	NOUN
dti-1305	194	2	and	and	CCONJ
dti-1305	194	3	urea	urea	NOUN
dti-1305	194	4	derivatives	derivative	NOUN
dti-1305	194	5	of	of	ADP
dti-1305	194	6	mepacrine	mepacrine	NOUN
dti-1305	194	7	with	with	ADP
dti-1305	194	8	varying	vary	VERB
dti-1305	194	9	methylene	methylene	NOUN
dti-1305	194	10	spacer	spacer	NOUN
dti-1305	194	11	lengths	length	NOUN
dti-1305	194	12	(	(	PUNCT
dti-1305	194	13	e.g.	e.g.	ADV
dti-1305	194	14	12	12	NUM
dti-1305	194	15	,	,	PUNCT
dti-1305	194	16	13	13	NUM
dti-1305	194	17	)	)	PUNCT
dti-1305	194	18	were	be	AUX
dti-1305	194	19	found	find	VERB
dti-1305	194	20	to	to	PART
dti-1305	194	21	be	be	AUX
dti-1305	194	22	superior	superior	ADJ
dti-1305	194	23	inhibitors	inhibitor	NOUN
dti-1305	194	24	of	of	ADP
dti-1305	194	25	tr	tr	PUNCT
dti-1305	194	26	relative	relative	ADJ
dti-1305	194	27	to	to	ADP
dti-1305	194	28	mepacrine	mepacrine	NOUN
dti-1305	194	29	with	with	ADP
dti-1305	194	30	the	the	DET
dti-1305	194	31	best	good	ADJ
dti-1305	194	32	inhibitors	inhibitor	NOUN
dti-1305	194	33	drug	drug	NOUN
dti-1305	194	34	target	target	NOUN
dti-1305	194	35	insights	insight	NOUN
dti-1305	194	36	2007	2007	NUM
dti-1305	194	37	:	:	PUNCT
dti-1305	194	38	2	2	NUM
dti-1305	194	39	137	137	NUM
dti-1305	194	40	target	target	NOUN
dti-1305	194	41	for	for	ADP
dti-1305	194	42	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	194	43	and	and	CCONJ
dti-1305	194	44	antileishmanial	antileishmanial	ADJ
dti-1305	194	45	drug	drug	NOUN
dti-1305	194	46	design	design	NOUN
dti-1305	194	47	n	n	NOUN
dti-1305	194	48	s	s	VERB
dti-1305	194	49	nh3c	nh3c	PROPN
dti-1305	194	50	h3c	h3c	NOUN
dti-1305	194	51	cl	cl	NOUN
dti-1305	194	52	chlorpromazine	chlorpromazine	NOUN
dti-1305	194	53	,	,	PUNCT
dti-1305	194	54	9	9	NUM
dti-1305	194	55	ki	ki	NOUN
dti-1305	194	56	=	=	PUNCT
dti-1305	194	57	10	10	NUM
dti-1305	194	58	m	m	NOUN
dti-1305	194	59	(	(	PUNCT
dti-1305	194	60	benson	benson	PROPN
dti-1305	194	61	et	et	NOUN
dti-1305	194	62	al.1992	al.1992	PROPN
dti-1305	194	63	)	)	PUNCT
dti-1305	194	64	n	n	CCONJ
dti-1305	194	65	nh3c	nh3c	PROPN
dti-1305	194	66	h3c	h3c	VERB
dti-1305	194	67	cl	cl	NOUN
dti-1305	194	68	clomipramine	clomipramine	NOUN
dti-1305	194	69	,	,	PUNCT
dti-1305	194	70	10	10	NUM
dti-1305	194	71	ki	ki	NOUN
dti-1305	194	72	=	=	NOUN
dti-1305	194	73	6.6	6.6	NUM
dti-1305	194	74	m	m	NOUN
dti-1305	194	75	(	(	PUNCT
dti-1305	194	76	benson	benson	PROPN
dti-1305	194	77	et	et	PROPN
dti-1305	194	78	al	al	PROPN
dti-1305	194	79	.	.	PROPN
dti-1305	194	80	1992	1992	NUM
dti-1305	194	81	)	)	PUNCT
dti-1305	195	1	n	n	CCONJ
dti-1305	195	2	hn	hn	PROPN
dti-1305	195	3	ch3	ch3	PROPN
dti-1305	195	4	ch2ch2ch2net2	ch2ch2ch2net2	PROPN
dti-1305	195	5	mepacrine	mepacrine	NOUN
dti-1305	195	6	,	,	PUNCT
dti-1305	195	7	11	11	NUM
dti-1305	195	8	ki	ki	NOUN
dti-1305	195	9	=	=	SYM
dti-1305	195	10	19	19	NUM
dti-1305	195	11	m	m	NOUN
dti-1305	195	12	(	(	PUNCT
dti-1305	195	13	jacoby	jacoby	PROPN
dti-1305	195	14	et	et	PROPN
dti-1305	195	15	al	al	PROPN
dti-1305	195	16	.	.	PROPN
dti-1305	195	17	1996	1996	NUM
dti-1305	195	18	)	)	PUNCT
dti-1305	195	19	cl	cl	NOUN
dti-1305	195	20	och3	och3	ADJ
dti-1305	195	21	n	n	CCONJ
dti-1305	195	22	hn	hn	PROPN
dti-1305	195	23	cl	cl	PROPN
dti-1305	195	24	och3	och3	ADJ
dti-1305	195	25	h	h	NOUN
dti-1305	195	26	n	n	NOUN
dti-1305	195	27	r	r	NOUN
dti-1305	195	28	r	r	NOUN
dti-1305	195	29	=	=	PUNCT
dti-1305	195	30	o2s	o2s	X
dti-1305	195	31	(	(	PUNCT
dti-1305	195	32	chibale	chibale	VERB
dti-1305	195	33	et	et	PROPN
dti-1305	195	34	al	al	PROPN
dti-1305	195	35	.	.	PROPN
dti-1305	195	36	2001	2001	NUM
dti-1305	195	37	)	)	PUNCT
dti-1305	196	1	r	r	NOUN
dti-1305	196	2	=	=	PUNCT
dti-1305	196	3	ochn	ochn	NOUN
dti-1305	196	4	i50	i50	PROPN
dti-1305	196	5	=	=	SYM
dti-1305	196	6	3.3	3.3	NUM
dti-1305	196	7	m	m	NOUN
dti-1305	196	8	i50	i50	NOUN
dti-1305	196	9	=	=	PUNCT
dti-1305	196	10	13.1	13.1	NUM
dti-1305	196	11	m	m	NOUN
dti-1305	196	12	o	o	NOUN
dti-1305	196	13	h3c	h3c	X
dti-1305	196	14	ch3	ch3	PROPN
dti-1305	196	15	nho	nho	PROPN
dti-1305	196	16	n	n	PROPN
dti-1305	196	17	ch3	ch3	PROPN
dti-1305	196	18	ch3	ch3	PROPN
dti-1305	196	19	nho	nho	PROPN
dti-1305	196	20	n	n	PROPN
dti-1305	196	21	ch3	ch3	PROPN
dti-1305	196	22	ch3	ch3	PROPN
dti-1305	196	23	14	14	NUM
dti-1305	196	24	,	,	PUNCT
dti-1305	196	25	i50	i50	NOUN
dti-1305	196	26	=	=	NUM
dti-1305	196	27	35.7	35.7	NUM
dti-1305	196	28	m	m	NOUN
dti-1305	196	29	(	(	PUNCT
dti-1305	196	30	chibale	chibale	PROPN
dti-1305	196	31	et	et	PROPN
dti-1305	196	32	al	al	PROPN
dti-1305	196	33	.	.	PROPN
dti-1305	196	34	2003	2003	NUM
dti-1305	196	35	)	)	PUNCT
dti-1305	196	36	12	12	NUM
dti-1305	196	37	,	,	PUNCT
dti-1305	196	38	13	13	NUM
dti-1305	196	39	,	,	PUNCT
dti-1305	196	40	figure	figure	NOUN
dti-1305	196	41	5	5	NUM
dti-1305	196	42	.	.	PUNCT
dti-1305	196	43	structures	structure	NOUN
dti-1305	196	44	and	and	CCONJ
dti-1305	196	45	activities	activity	NOUN
dti-1305	196	46	of	of	ADP
dti-1305	196	47	tricyclic	tricyclic	ADJ
dti-1305	196	48	inhibitors	inhibitor	NOUN
dti-1305	196	49	of	of	ADP
dti-1305	196	50	trypanothione	trypanothione	NOUN
dti-1305	196	51	reductase	reductase	NOUN
dti-1305	196	52	.	.	PUNCT
dti-1305	197	1	being	be	AUX
dti-1305	197	2	40	40	NUM
dti-1305	197	3	-	-	NOUN
dti-1305	197	4	fold	fold	VERB
dti-1305	197	5	more	more	ADV
dti-1305	197	6	potent	potent	ADJ
dti-1305	197	7	(	(	PUNCT
dti-1305	197	8	chibale	chibale	PROPN
dti-1305	197	9	et	et	PROPN
dti-1305	197	10	al	al	PROPN
dti-1305	197	11	.	.	PROPN
dti-1305	197	12	2001	2001	NUM
dti-1305	197	13	)	)	PUNCT
dti-1305	197	14	.	.	PUNCT
dti-1305	198	1	a	a	DET
dti-1305	198	2	series	series	NOUN
dti-1305	198	3	of	of	ADP
dti-1305	198	4	synthetic	synthetic	ADJ
dti-1305	198	5	9,9	9,9	NUM
dti-1305	198	6	-	-	PUNCT
dti-1305	198	7	dimethylxanthene	dimethylxanthene	ADJ
dti-1305	198	8	derivatives	derivative	NOUN
dti-1305	198	9	(	(	PUNCT
dti-1305	198	10	e.g.	e.g.	ADV
dti-1305	198	11	14	14	NUM
dti-1305	198	12	)	)	PUNCT
dti-1305	198	13	were	be	AUX
dti-1305	198	14	shown	show	VERB
dti-1305	198	15	to	to	PART
dti-1305	198	16	be	be	AUX
dti-1305	198	17	competitive	competitive	ADJ
dti-1305	198	18	inhibitors	inhibitor	NOUN
dti-1305	198	19	of	of	ADP
dti-1305	198	20	tr	tr	VERB
dti-1305	198	21	which	which	PRON
dti-1305	198	22	are	be	AUX
dti-1305	198	23	comparable	comparable	ADJ
dti-1305	198	24	to	to	ADP
dti-1305	198	25	known	know	VERB
dti-1305	198	26	tricyclic	tricyclic	ADJ
dti-1305	198	27	inhibitors	inhibitor	NOUN
dti-1305	198	28	of	of	ADP
dti-1305	198	29	tr	tr	VERB
dti-1305	198	30	(	(	PUNCT
dti-1305	198	31	chibale	chibale	PROPN
dti-1305	198	32	et	et	PROPN
dti-1305	198	33	al	al	PROPN
dti-1305	198	34	.	.	PROPN
dti-1305	198	35	2003	2003	NUM
dti-1305	198	36	)	)	PUNCT
dti-1305	198	37	.	.	PUNCT
dti-1305	199	1	it	it	PRON
dti-1305	199	2	is	be	AUX
dti-1305	199	3	important	important	ADJ
dti-1305	199	4	to	to	PART
dti-1305	199	5	note	note	VERB
dti-1305	199	6	that	that	SCONJ
dti-1305	199	7	as	as	SCONJ
dti-1305	199	8	required	require	VERB
dti-1305	199	9	in	in	ADP
dti-1305	199	10	principle	principle	NOUN
dti-1305	199	11	for	for	ADP
dti-1305	199	12	an	an	DET
dti-1305	199	13	ideal	ideal	ADJ
dti-1305	199	14	drug	drug	NOUN
dti-1305	199	15	target	target	NOUN
dti-1305	199	16	,	,	PUNCT
dti-1305	199	17	inhibition	inhibition	NOUN
dti-1305	199	18	of	of	ADP
dti-1305	199	19	tr	tr	VERB
dti-1305	199	20	in	in	ADP
dti-1305	199	21	vitro	vitro	X
dti-1305	199	22	should	should	AUX
dti-1305	199	23	also	also	ADV
dti-1305	199	24	correlate	correlate	VERB
dti-1305	199	25	with	with	ADP
dti-1305	199	26	antiparasitic	antiparasitic	ADJ
dti-1305	199	27	activity	activity	NOUN
dti-1305	199	28	in	in	ADP
dti-1305	199	29	vitro	vitro	X
dti-1305	199	30	against	against	ADP
dti-1305	199	31	t.	t.	PROPN
dti-1305	199	32	brucei	brucei	PROPN
dti-1305	199	33	,	,	PUNCT
dti-1305	199	34	t.	t.	PROPN
dti-1305	199	35	cruzi	cruzi	PROPN
dti-1305	199	36	and	and	CCONJ
dti-1305	199	37	l.	l.	PROPN
dti-1305	199	38	donovani	donovani	PROPN
dti-1305	199	39	.	.	PUNCT
dti-1305	200	1	however	however	ADV
dti-1305	200	2	,	,	PUNCT
dti-1305	200	3	no	no	DET
dti-1305	200	4	strong	strong	ADJ
dti-1305	200	5	correlation	correlation	NOUN
dti-1305	200	6	between	between	ADP
dti-1305	200	7	tr	tr	VERB
dti-1305	200	8	-	-	ADJ
dti-1305	200	9	inhibitory	inhibitory	ADJ
dti-1305	200	10	activity	activity	NOUN
dti-1305	200	11	and	and	CCONJ
dti-1305	200	12	in	in	ADP
dti-1305	200	13	vitro	vitro	X
dti-1305	200	14	antiparasitic	antiparasitic	ADJ
dti-1305	200	15	activity	activity	NOUN
dti-1305	200	16	was	be	AUX
dti-1305	200	17	observed	observe	VERB
dti-1305	200	18	indicative	indicative	ADJ
dti-1305	200	19	of	of	ADP
dti-1305	200	20	unfavorable	unfavorable	ADJ
dti-1305	200	21	pharmacokinetic	pharmacokinetic	ADJ
dti-1305	200	22	profi	profi	NOUN
dti-1305	200	23	les	le	NOUN
dti-1305	200	24	.	.	PUNCT
dti-1305	201	1	2	2	NUM
dti-1305	201	2	-	-	PUNCT
dti-1305	201	3	aminodiphenylsulfi	aminodiphenylsulfi	NOUN
dti-1305	201	4	des	de	NOUN
dti-1305	201	5	and	and	CCONJ
dti-1305	201	6	its	its	PRON
dti-1305	201	7	congeners	congener	NOUN
dti-1305	201	8	modifi	modifi	NOUN
dti-1305	201	9	cation	cation	NOUN
dti-1305	201	10	of	of	ADP
dti-1305	201	11	the	the	DET
dti-1305	201	12	central	central	ADJ
dti-1305	201	13	ring	ring	NOUN
dti-1305	201	14	of	of	ADP
dti-1305	201	15	the	the	DET
dti-1305	201	16	phenothiazines	phenothiazine	NOUN
dti-1305	201	17	furnished	furnish	VERB
dti-1305	201	18	the	the	DET
dti-1305	201	19	2	2	NUM
dti-1305	201	20	-	-	PUNCT
dti-1305	201	21	aminodiphenylsulfides	aminodiphenylsulfide	NOUN
dti-1305	201	22	,	,	PUNCT
dti-1305	201	23	termed	term	VERB
dti-1305	201	24	‘	'	PUNCT
dti-1305	201	25	open	open	ADJ
dti-1305	201	26	chain	chain	NOUN
dti-1305	201	27	chlorpromazines	chlorpromazine	NOUN
dti-1305	201	28	’	'	PUNCT
dti-1305	201	29	.	.	PUNCT
dti-1305	202	1	using	use	VERB
dti-1305	202	2	a	a	DET
dti-1305	202	3	microplate	microplate	NOUN
dti-1305	202	4	assay	assay	VERB
dti-1305	202	5	to	to	PART
dti-1305	202	6	screen	screen	VERB
dti-1305	202	7	tr	tr	NOUN
dti-1305	202	8	inhibitors	inhibitor	NOUN
dti-1305	202	9	,	,	PUNCT
dti-1305	202	10	this	this	DET
dti-1305	202	11	group	group	NOUN
dti-1305	202	12	of	of	ADP
dti-1305	202	13	compounds	compound	NOUN
dti-1305	202	14	was	be	AUX
dti-1305	202	15	discovered	discover	VERB
dti-1305	202	16	to	to	PART
dti-1305	202	17	be	be	AUX
dti-1305	202	18	potent	potent	ADJ
dti-1305	202	19	competitive	competitive	ADJ
dti-1305	202	20	inhibitors	inhibitor	NOUN
dti-1305	202	21	(	(	PUNCT
dti-1305	202	22	fig	fig	NOUN
dti-1305	202	23	.	.	PUNCT
dti-1305	203	1	6	6	NUM
dti-1305	203	2	)	)	PUNCT
dti-1305	203	3	.	.	PUNCT
dti-1305	204	1	compound	compound	NOUN
dti-1305	204	2	15	15	NUM
dti-1305	204	3	was	be	AUX
dti-1305	204	4	the	the	DET
dti-1305	204	5	best	good	ADJ
dti-1305	204	6	inhibitor	inhibitor	NOUN
dti-1305	204	7	in	in	ADP
dti-1305	204	8	the	the	DET
dti-1305	204	9	preliminary	preliminary	ADJ
dti-1305	204	10	series	series	NOUN
dti-1305	204	11	(	(	PUNCT
dti-1305	204	12	fernandezgomez	fernandezgomez	NOUN
dti-1305	204	13	et	et	PROPN
dti-1305	204	14	al	al	PROPN
dti-1305	204	15	.	.	PROPN
dti-1305	204	16	1995	1995	NUM
dti-1305	204	17	)	)	PUNCT
dti-1305	204	18	.	.	PUNCT
dti-1305	205	1	based	base	VERB
dti-1305	205	2	on	on	ADP
dti-1305	205	3	these	these	DET
dti-1305	205	4	results	result	NOUN
dti-1305	205	5	and	and	CCONJ
dti-1305	205	6	molecular	molecular	ADJ
dti-1305	205	7	modeling	modeling	NOUN
dti-1305	205	8	studies	study	NOUN
dti-1305	205	9	,	,	PUNCT
dti-1305	205	10	a	a	DET
dti-1305	205	11	series	series	NOUN
dti-1305	205	12	of	of	ADP
dti-1305	205	13	bis	bis	PROPN
dti-1305	205	14	(	(	PUNCT
dti-1305	205	15	2	2	NUM
dti-1305	205	16	-	-	PUNCT
dti-1305	205	17	aminodiphenylsulfi	aminodiphenylsulfi	NOUN
dti-1305	205	18	des	des	PROPN
dti-1305	205	19	)	)	PUNCT
dti-1305	205	20	were	be	AUX
dti-1305	205	21	synthesized	synthesize	VERB
dti-1305	205	22	and	and	CCONJ
dti-1305	205	23	compound	compound	VERB
dti-1305	205	24	16	16	NUM
dti-1305	205	25	was	be	AUX
dti-1305	205	26	shown	show	VERB
dti-1305	205	27	to	to	PART
dti-1305	205	28	be	be	AUX
dti-1305	205	29	the	the	DET
dti-1305	205	30	most	most	ADV
dti-1305	205	31	potent	potent	ADJ
dti-1305	205	32	in	in	ADP
dti-1305	205	33	this	this	DET
dti-1305	205	34	series	series	NOUN
dti-1305	205	35	(	(	PUNCT
dti-1305	205	36	girault	girault	NOUN
dti-1305	205	37	et	et	PROPN
dti-1305	205	38	al	al	PROPN
dti-1305	205	39	.	.	PROPN
dti-1305	205	40	1997	1997	NUM
dti-1305	205	41	)	)	PUNCT
dti-1305	205	42	.	.	PUNCT
dti-1305	206	1	further	further	ADJ
dti-1305	206	2	improvement	improvement	NOUN
dti-1305	206	3	was	be	AUX
dti-1305	206	4	evident	evident	ADJ
dti-1305	206	5	with	with	ADP
dti-1305	206	6	a	a	DET
dti-1305	206	7	newer	new	ADJ
dti-1305	206	8	generation	generation	NOUN
dti-1305	206	9	of	of	ADP
dti-1305	206	10	bis(2	bis(2	NOUN
dti-1305	206	11	-	-	PUNCT
dti-1305	206	12	aminodiphenylsulfides	aminodiphenylsulfides	ADJ
dti-1305	206	13	)	)	PUNCT
dti-1305	206	14	(	(	PUNCT
dti-1305	206	15	e.g.	e.g.	ADV
dti-1305	206	16	17	17	NUM
dti-1305	206	17	)	)	PUNCT
dti-1305	206	18	corresponding	correspond	VERB
dti-1305	206	19	to	to	ADP
dti-1305	206	20	attachment	attachment	NOUN
dti-1305	206	21	of	of	ADP
dti-1305	206	22	an	an	DET
dti-1305	206	23	additional	additional	ADJ
dti-1305	206	24	hydrophobic	hydrophobic	NOUN
dti-1305	206	25	side	side	NOUN
dti-1305	206	26	to	to	ADP
dti-1305	206	27	an	an	DET
dti-1305	206	28	analog	analog	NOUN
dti-1305	206	29	of	of	ADP
dti-1305	206	30	compound	compound	NOUN
dti-1305	206	31	16	16	NUM
dti-1305	206	32	.	.	PUNCT
dti-1305	207	1	the	the	DET
dti-1305	207	2	large	large	ADJ
dti-1305	207	3	volume	volume	NOUN
dti-1305	207	4	of	of	ADP
dti-1305	207	5	the	the	DET
dti-1305	207	6	tr	tr	PUNCT
dti-1305	207	7	active	active	ADJ
dti-1305	207	8	site	site	NOUN
dti-1305	207	9	justifi	justifi	NOUN
dti-1305	207	10	ed	ed	PROPN
dti-1305	207	11	the	the	DET
dti-1305	207	12	introduction	introduction	NOUN
dti-1305	207	13	of	of	ADP
dti-1305	207	14	an	an	DET
dti-1305	207	15	additional	additional	ADJ
dti-1305	207	16	hydrophobic	hydrophobic	NOUN
dti-1305	207	17	group	group	NOUN
dti-1305	207	18	to	to	ADP
dti-1305	207	19	the	the	DET
dti-1305	207	20	end	end	NOUN
dti-1305	207	21	of	of	ADP
dti-1305	207	22	the	the	DET
dti-1305	207	23	side	side	NOUN
dti-1305	207	24	chain	chain	NOUN
dti-1305	207	25	(	(	PUNCT
dti-1305	207	26	girault	girault	NOUN
dti-1305	207	27	et	et	PROPN
dti-1305	207	28	al	al	PROPN
dti-1305	207	29	.	.	PROPN
dti-1305	207	30	2001	2001	NUM
dti-1305	207	31	)	)	PUNCT
dti-1305	207	32	.	.	PUNCT
dti-1305	208	1	all	all	DET
dti-1305	208	2	the	the	DET
dti-1305	208	3	compounds	compound	NOUN
dti-1305	208	4	demonstrated	demonstrate	VERB
dti-1305	208	5	antiparasitic	antiparasitic	ADJ
dti-1305	208	6	activity	activity	NOUN
dti-1305	208	7	in	in	ADP
dti-1305	208	8	vitro	vitro	X
dti-1305	208	9	at	at	ADP
dti-1305	208	10	low	low	ADJ
dti-1305	208	11	micromolar	micromolar	ADJ
dti-1305	208	12	ranges	range	NOUN
dti-1305	208	13	.	.	PUNCT
dti-1305	209	1	however	however	ADV
dti-1305	209	2	,	,	PUNCT
dti-1305	209	3	no	no	DET
dti-1305	209	4	correlations	correlation	NOUN
dti-1305	209	5	between	between	ADP
dti-1305	209	6	tr	tr	NOUN
dti-1305	209	7	inhibition	inhibition	NOUN
dti-1305	209	8	and	and	CCONJ
dti-1305	209	9	in	in	ADP
dti-1305	209	10	vitro	vitro	X
dti-1305	209	11	antiparasitic	antiparasitic	ADJ
dti-1305	209	12	activity	activity	NOUN
dti-1305	209	13	were	be	AUX
dti-1305	209	14	apparent	apparent	ADJ
dti-1305	209	15	.	.	PUNCT
dti-1305	210	1	quaternary	quaternary	ADJ
dti-1305	210	2	alkylammonium	alkylammonium	NOUN
dti-1305	210	3	compounds	compound	VERB
dti-1305	210	4	the	the	DET
dti-1305	210	5	quaternization	quaternization	NOUN
dti-1305	210	6	of	of	ADP
dti-1305	210	7	tertiary	tertiary	ADJ
dti-1305	210	8	alkylamine	alkylamine	NOUN
dti-1305	210	9	ω	ω	PROPN
dti-1305	210	10	-	-	PUNCT
dti-1305	210	11	nitrogen	nitrogen	NOUN
dti-1305	210	12	atom	atom	NOUN
dti-1305	210	13	of	of	ADP
dti-1305	210	14	chlorpromazine	chlorpromazine	NOUN
dti-1305	210	15	by	by	ADP
dti-1305	210	16	substituted	substitute	VERB
dti-1305	210	17	benzyl	benzyl	NOUN
dti-1305	210	18	and	and	CCONJ
dti-1305	210	19	other	other	ADJ
dti-1305	210	20	aromatic	aromatic	ADJ
dti-1305	210	21	or	or	CCONJ
dti-1305	210	22	heterocyclic	heterocyclic	ADJ
dti-1305	210	23	groups	group	NOUN
dti-1305	210	24	resulted	result	VERB
dti-1305	210	25	the	the	DET
dti-1305	210	26	discovery	discovery	NOUN
dti-1305	210	27	of	of	ADP
dti-1305	210	28	quaternary	quaternary	ADJ
dti-1305	210	29	alkylammonium	alkylammonium	NOUN
dti-1305	210	30	phenothiazines	phenothiazine	NOUN
dti-1305	210	31	as	as	ADP
dti-1305	210	32	a	a	DET
dti-1305	210	33	new	new	ADJ
dti-1305	210	34	class	class	NOUN
dti-1305	210	35	of	of	ADP
dti-1305	210	36	linear	linear	ADJ
dti-1305	210	37	competitive	competitive	ADJ
dti-1305	210	38	inhibitors	inhibitor	NOUN
dti-1305	210	39	of	of	ADP
dti-1305	210	40	tr	tr	VERB
dti-1305	210	41	(	(	PUNCT
dti-1305	210	42	fig	fig	NOUN
dti-1305	210	43	.	.	PUNCT
dti-1305	211	1	7	7	X
dti-1305	211	2	)	)	PUNCT
dti-1305	211	3	(	(	PUNCT
dti-1305	211	4	khan	khan	PROPN
dti-1305	211	5	et	et	PROPN
dti-1305	211	6	al	al	PROPN
dti-1305	211	7	.	.	PROPN
dti-1305	211	8	2000	2000	NUM
dti-1305	211	9	)	)	PUNCT
dti-1305	211	10	.	.	PUNCT
dti-1305	212	1	the	the	DET
dti-1305	212	2	permanent	permanent	ADJ
dti-1305	212	3	positive	positive	ADJ
dti-1305	212	4	charge	charge	NOUN
dti-1305	212	5	on	on	ADP
dti-1305	212	6	the	the	DET
dti-1305	212	7	distal	distal	ADJ
dti-1305	212	8	nitrogen	nitrogen	NOUN
dti-1305	212	9	atom	atom	NOUN
dti-1305	212	10	of	of	ADP
dti-1305	212	11	the	the	DET
dti-1305	212	12	tricyclic	tricyclic	NOUN
dti-1305	212	13	’s	’s	PART
dti-1305	212	14	side	side	NOUN
dti-1305	212	15	chain	chain	NOUN
dti-1305	212	16	contributed	contribute	VERB
dti-1305	212	17	to	to	ADP
dti-1305	212	18	binding	bind	VERB
dti-1305	212	19	was	be	AUX
dti-1305	212	20	estimated	estimate	VERB
dti-1305	212	21	as	as	ADP
dti-1305	212	22	≥5.6	≥5.6	PROPN
dti-1305	212	23	kcal.mol-1	kcal.mol-1	NOUN
dti-1305	212	24	by	by	ADP
dti-1305	212	25	comparison	comparison	NOUN
dti-1305	212	26	with	with	ADP
dti-1305	212	27	the	the	DET
dti-1305	212	28	analog	analog	NOUN
dti-1305	212	29	with	with	ADP
dti-1305	212	30	cationic	cationic	ADJ
dti-1305	212	31	nitrogen	nitrogen	NOUN
dti-1305	212	32	atom	atom	NOUN
dti-1305	212	33	of	of	ADP
dti-1305	212	34	the	the	DET
dti-1305	212	35	quaternary	quaternary	ADJ
dti-1305	212	36	(	(	PUNCT
dti-1305	212	37	18	18	NUM
dti-1305	212	38	)	)	PUNCT
dti-1305	212	39	replaced	replace	VERB
dti-1305	212	40	by	by	ADP
dti-1305	212	41	an	an	DET
dti-1305	212	42	ether	ether	ADJ
dti-1305	212	43	oxygen	oxygen	NOUN
dti-1305	212	44	atom	atom	NOUN
dti-1305	212	45	(	(	PUNCT
dti-1305	212	46	19	19	NUM
dti-1305	212	47	)	)	PUNCT
dti-1305	212	48	.	.	PUNCT
dti-1305	213	1	the	the	DET
dti-1305	213	2	major	major	ADJ
dti-1305	213	3	contribution	contribution	NOUN
dti-1305	213	4	to	to	ADP
dti-1305	213	5	improving	improve	VERB
dti-1305	213	6	ki	ki	PROPN
dti-1305	213	7	value	value	NOUN
dti-1305	213	8	and	and	CCONJ
dti-1305	213	9	inhibition	inhibition	NOUN
dti-1305	213	10	strength	strength	NOUN
dti-1305	213	11	was	be	AUX
dti-1305	213	12	accomplished	accomplish	VERB
dti-1305	213	13	by	by	ADP
dti-1305	213	14	incorporating	incorporate	VERB
dti-1305	213	15	the	the	DET
dti-1305	213	16	hydrophobic	hydrophobic	NOUN
dti-1305	213	17	n	n	CCONJ
dti-1305	213	18	-	-	PUNCT
dti-1305	213	19	benzyl	benzyl	NOUN
dti-1305	213	20	substituents	substituent	NOUN
dti-1305	213	21	.	.	PUNCT
dti-1305	214	1	the	the	DET
dti-1305	214	2	best	good	ADJ
dti-1305	214	3	inhibitor	inhibitor	NOUN
dti-1305	214	4	identified	identify	VERB
dti-1305	214	5	was	be	AUX
dti-1305	214	6	compound	compound	NOUN
dti-1305	214	7	19	19	NUM
dti-1305	214	8	,	,	PUNCT
dti-1305	214	9	containing	contain	VERB
dti-1305	214	10	a	a	DET
dti-1305	214	11	3	3	NUM
dti-1305	214	12	,	,	PUNCT
dti-1305	214	13	drug	drug	NOUN
dti-1305	214	14	target	target	NOUN
dti-1305	214	15	insights	insight	NOUN
dti-1305	214	16	2007	2007	NUM
dti-1305	214	17	:	:	PUNCT
dti-1305	214	18	2	2	NUM
dti-1305	214	19	138	138	NUM
dti-1305	214	20	khan	khan	PROPN
dti-1305	214	21	n	n	PROPN
dti-1305	214	22	s	s	NOUN
dti-1305	214	23	n+h3c	n+h3c	NOUN
dti-1305	215	1	h3c	h3c	X
dti-1305	215	2	cl	cl	NOUN
dti-1305	215	3	cl	cl	NOUN
dti-1305	215	4	clcl18	clcl18	NOUN
dti-1305	215	5	,	,	PUNCT
dti-1305	215	6	ki	ki	PROPN
dti-1305	216	1	=	=	PROPN
dti-1305	216	2	0.12	0.12	NUM
dti-1305	216	3	m	m	PROPN
dti-1305	216	4	(	(	PUNCT
dti-1305	216	5	khan	khan	PROPN
dti-1305	216	6	et	et	PROPN
dti-1305	216	7	al	al	PROPN
dti-1305	216	8	.	.	PROPN
dti-1305	216	9	2000	2000	NUM
dti-1305	216	10	)	)	PUNCT
dti-1305	217	1	n	n	PRON
dti-1305	217	2	s	s	PART
dti-1305	217	3	o	o	NOUN
dti-1305	217	4	cl	cl	NOUN
dti-1305	217	5	cl	cl	NOUN
dti-1305	217	6	cl	cl	NOUN
dti-1305	217	7	19	19	NUM
dti-1305	217	8	,	,	PUNCT
dti-1305	217	9	no	no	DET
dti-1305	217	10	inhibition	inhibition	NOUN
dti-1305	217	11	at	at	ADP
dti-1305	217	12	50	50	NUM
dti-1305	217	13	m	m	NOUN
dti-1305	217	14	(	(	PUNCT
dti-1305	217	15	khan	khan	PROPN
dti-1305	217	16	et	et	PROPN
dti-1305	217	17	al	al	PROPN
dti-1305	217	18	.	.	PROPN
dti-1305	217	19	2000	2000	NUM
dti-1305	217	20	)	)	PUNCT
dti-1305	218	1	nh	nh	PROPN
dti-1305	218	2	s	s	PROPN
dti-1305	218	3	n+h3c	n+h3c	NOUN
dti-1305	218	4	h3c	h3c	X
dti-1305	218	5	cl	cl	NOUN
dti-1305	218	6	cl	cl	NOUN
dti-1305	218	7	clcl20	clcl20	NOUN
dti-1305	218	8	,	,	PUNCT
dti-1305	218	9	ki	ki	PROPN
dti-1305	218	10	=	=	PUNCT
dti-1305	218	11	1.7	1.7	NUM
dti-1305	218	12	m	m	NOUN
dti-1305	218	13	(	(	PUNCT
dti-1305	218	14	parveen	parveen	PROPN
dti-1305	218	15	et	et	PROPN
dti-1305	218	16	al	al	PROPN
dti-1305	218	17	.	.	PROPN
dti-1305	218	18	2005	2005	NUM
dti-1305	218	19	)	)	PUNCT
dti-1305	218	20	figure	figure	NOUN
dti-1305	218	21	7	7	NUM
dti-1305	218	22	.	.	PUNCT
dti-1305	218	23	structures	structure	NOUN
dti-1305	218	24	of	of	ADP
dti-1305	218	25	quaternary	quaternary	ADJ
dti-1305	218	26	alkylammonium	alkylammonium	NOUN
dti-1305	218	27	compounds	compound	NOUN
dti-1305	218	28	with	with	ADP
dti-1305	218	29	their	their	PRON
dti-1305	218	30	anti	anti	ADJ
dti-1305	218	31	-	-	ADJ
dti-1305	218	32	tr	tr	ADJ
dti-1305	218	33	activities	activity	NOUN
dti-1305	218	34	.	.	PUNCT
dti-1305	219	1	4	4	NUM
dti-1305	219	2	-	-	NUM
dti-1305	219	3	dichlorobenzyl	dichlorobenzyl	NOUN
dti-1305	219	4	substituent	substituent	NOUN
dti-1305	219	5	(	(	PUNCT
dti-1305	219	6	~2	~2	NOUN
dti-1305	219	7	orders	order	NOUN
dti-1305	219	8	of	of	ADP
dti-1305	219	9	magnitude	magnitude	NOUN
dti-1305	219	10	>	>	X
dti-1305	219	11	chlorpromazine	chlorpromazine	NOUN
dti-1305	219	12	)	)	PUNCT
dti-1305	219	13	.	.	PUNCT
dti-1305	220	1	detailed	detailed	ADJ
dti-1305	220	2	molecular	molecular	ADJ
dti-1305	220	3	modeling	modeling	NOUN
dti-1305	220	4	studies	study	NOUN
dti-1305	220	5	helped	help	VERB
dti-1305	220	6	to	to	PART
dti-1305	220	7	establish	establish	VERB
dti-1305	220	8	docking	docking	NOUN
dti-1305	220	9	orientations	orientation	NOUN
dti-1305	220	10	and	and	CCONJ
dti-1305	220	11	energies	energy	NOUN
dti-1305	220	12	by	by	ADP
dti-1305	220	13	revealing	reveal	VERB
dti-1305	220	14	involvement	involvement	NOUN
dti-1305	220	15	of	of	ADP
dti-1305	220	16	:	:	PUNCT
dti-1305	220	17	(	(	PUNCT
dti-1305	220	18	i	i	NOUN
dti-1305	220	19	)	)	PUNCT
dti-1305	220	20	the	the	DET
dti-1305	220	21	major	major	ADJ
dti-1305	220	22	hydrophobic	hydrophobic	NOUN
dti-1305	220	23	pocket	pocket	NOUN
dti-1305	220	24	(	(	PUNCT
dti-1305	220	25	trp21	trp21	ADJ
dti-1305	220	26	,	,	PUNCT
dti-1305	220	27	met113	met113	PROPN
dti-1305	220	28	,	,	PUNCT
dti-1305	220	29	tyr110	tyr110	PROPN
dti-1305	220	30	)	)	PUNCT
dti-1305	220	31	,	,	PUNCT
dti-1305	220	32	(	(	PUNCT
dti-1305	220	33	ii	ii	NOUN
dti-1305	220	34	)	)	PUNCT
dti-1305	220	35	the	the	DET
dti-1305	220	36	“	"	PUNCT
dti-1305	220	37	z”-site	z”-site	NOUN
dti-1305	220	38	(	(	PUNCT
dti-1305	220	39	phe396	phe396	PROPN
dti-1305	220	40	’	'	PUNCT
dti-1305	220	41	,	,	PUNCT
dti-1305	220	42	pro398	pro398	PROPN
dti-1305	220	43	’	'	PUNCT
dti-1305	220	44	,	,	PUNCT
dti-1305	220	45	leu399	leu399	PROPN
dti-1305	220	46	’	'	PUNCT
dti-1305	220	47	)	)	PUNCT
dti-1305	220	48	and	and	CCONJ
dti-1305	220	49	(	(	PUNCT
dti-1305	220	50	iii	iii	X
dti-1305	220	51	)	)	PUNCT
dti-1305	220	52	the	the	DET
dti-1305	220	53	ionic	ionic	ADJ
dti-1305	220	54	interactions	interaction	NOUN
dti-1305	220	55	possible	possible	ADJ
dti-1305	220	56	for	for	ADP
dti-1305	220	57	the	the	DET
dti-1305	220	58	quaternary	quaternary	ADJ
dti-1305	220	59	cationic	cationic	ADJ
dti-1305	220	60	nitrogen	nitrogen	NOUN
dti-1305	220	61	with	with	ADP
dti-1305	220	62	nearby	nearby	ADJ
dti-1305	220	63	side	side	NOUN
dti-1305	220	64	chains	chain	NOUN
dti-1305	220	65	of	of	ADP
dti-1305	220	66	glu466	glu466	NOUN
dti-1305	220	67	’	'	PUNCT
dti-1305	220	68	and	and	CCONJ
dti-1305	220	69	glu467	glu467	PROPN
dti-1305	220	70	’	'	PUNCT
dti-1305	220	71	(	(	PUNCT
dti-1305	220	72	fig	fig	NOUN
dti-1305	220	73	.	.	PUNCT
dti-1305	221	1	8)	8)	NUM
dti-1305	221	2	(	(	PUNCT
dti-1305	221	3	austin	austin	PROPN
dti-1305	221	4	et	et	PROPN
dti-1305	221	5	al	al	PROPN
dti-1305	221	6	.	.	PROPN
dti-1305	221	7	1999	1999	NUM
dti-1305	221	8	,	,	PUNCT
dti-1305	221	9	khan	khan	PROPN
dti-1305	221	10	et	et	PROPN
dti-1305	221	11	al	al	PROPN
dti-1305	221	12	.	.	PROPN
dti-1305	221	13	2000	2000	NUM
dti-1305	221	14	)	)	PUNCT
dti-1305	221	15	.	.	PUNCT
dti-1305	222	1	this	this	DET
dti-1305	222	2	“	"	PUNCT
dti-1305	222	3	three	three	NUM
dti-1305	222	4	point	point	NOUN
dti-1305	222	5	attachment	attachment	NOUN
dti-1305	222	6	”	"	PUNCT
dti-1305	222	7	,	,	PUNCT
dti-1305	222	8	a	a	DET
dti-1305	222	9	concept	concept	NOUN
dti-1305	222	10	initially	initially	ADV
dti-1305	222	11	designed	design	VERB
dti-1305	222	12	by	by	ADP
dti-1305	222	13	ogston	ogston	PROPN
dti-1305	222	14	(	(	PUNCT
dti-1305	222	15	1948	1948	NUM
dti-1305	222	16	)	)	PUNCT
dti-1305	222	17	to	to	PART
dti-1305	222	18	explain	explain	VERB
dti-1305	222	19	chiral	chiral	ADJ
dti-1305	222	20	specifi	specifi	PROPN
dti-1305	222	21	city	city	PROPN
dti-1305	222	22	of	of	ADP
dti-1305	222	23	enzymes	enzyme	NOUN
dti-1305	222	24	,	,	PUNCT
dti-1305	222	25	has	have	AUX
dti-1305	222	26	allowed	allow	VERB
dti-1305	222	27	on	on	ADP
dti-1305	222	28	average	average	VERB
dti-1305	222	29	a	a	DET
dti-1305	222	30	30	30	NUM
dti-1305	222	31	-	-	ADJ
dti-1305	222	32	fold	fold	ADJ
dti-1305	222	33	improvement	improvement	NOUN
dti-1305	222	34	of	of	ADP
dti-1305	222	35	ki	ki	PROPN
dti-1305	222	36	values	value	NOUN
dti-1305	222	37	against	against	ADP
dti-1305	222	38	tr	tr	X
dti-1305	222	39	(	(	PUNCT
dti-1305	222	40	khan	khan	PROPN
dti-1305	222	41	et	et	PROPN
dti-1305	222	42	al	al	PROPN
dti-1305	222	43	.	.	PROPN
dti-1305	222	44	2000	2000	NUM
dti-1305	222	45	)	)	PUNCT
dti-1305	222	46	.	.	PUNCT
dti-1305	223	1	similarly	similarly	ADV
dti-1305	223	2	,	,	PUNCT
dti-1305	223	3	the	the	DET
dti-1305	223	4	quaternization	quaternization	NOUN
dti-1305	223	5	of	of	ADP
dti-1305	223	6	the	the	DET
dti-1305	223	7	side	side	NOUN
dti-1305	223	8	chain	chain	NOUN
dti-1305	223	9	tertiary	tertiary	ADJ
dti-1305	223	10	nitrogen	nitrogen	NOUN
dti-1305	223	11	atom	atom	NOUN
dti-1305	223	12	of	of	ADP
dti-1305	223	13	the	the	DET
dti-1305	223	14	‘	'	PUNCT
dti-1305	223	15	open	open	ADJ
dti-1305	223	16	chain	chain	NOUN
dti-1305	223	17	chlorpromazines	chlorpromazine	NOUN
dti-1305	223	18	’	'	PUNCT
dti-1305	223	19	also	also	ADV
dti-1305	223	20	showed	show	VERB
dti-1305	223	21	improvements	improvement	NOUN
dti-1305	223	22	in	in	ADP
dti-1305	223	23	inhibition	inhibition	NOUN
dti-1305	223	24	up	up	ADP
dti-1305	223	25	to	to	ADP
dti-1305	223	26	nh	nh	PROPN
dti-1305	223	27	s	s	PART
dti-1305	223	28	n	n	ADP
dti-1305	223	29	cl	cl	NOUN
dti-1305	223	30	n	n	NOUN
dti-1305	223	31	h3c	h3c	NOUN
dti-1305	223	32	15	15	NUM
dti-1305	223	33	,	,	PUNCT
dti-1305	223	34	ki	ki	PROPN
dti-1305	224	1	=	=	PUNCT
dti-1305	225	1	25	25	NUM
dti-1305	225	2	m	m	NOUN
dti-1305	225	3	(	(	PUNCT
dti-1305	225	4	fernandez	fernandez	PROPN
dti-1305	225	5	-	-	PUNCT
dti-1305	225	6	gomez	gomez	PROPN
dti-1305	225	7	et	et	PROPN
dti-1305	225	8	al	al	PROPN
dti-1305	225	9	.	.	PROPN
dti-1305	225	10	1995	1995	NUM
dti-1305	225	11	)	)	PUNCT
dti-1305	225	12	nh	nh	PROPN
dti-1305	225	13	s	s	PART
dti-1305	225	14	n	n	CCONJ
dti-1305	225	15	br	br	NOUN
dti-1305	226	1	n	n	NOUN
dti-1305	226	2	h3c	h3c	VERB
dti-1305	226	3	h	h	NOUN
dti-1305	226	4	n	n	ADP
dti-1305	226	5	h	h	NOUN
dti-1305	227	1	n	n	CCONJ
dti-1305	227	2	hn	hn	PROPN
dti-1305	227	3	s	s	VERB
dti-1305	227	4	n	n	PRON
dti-1305	227	5	br	br	NOUN
dti-1305	227	6	n	n	NOUN
dti-1305	227	7	ch3	ch3	PROPN
dti-1305	228	1	o	o	NOUN
dti-1305	228	2	o	o	NOUN
dti-1305	228	3	16	16	NUM
dti-1305	228	4	,	,	PUNCT
dti-1305	228	5	i50	i50	NOUN
dti-1305	228	6	=	=	NUM
dti-1305	228	7	0.55	0.55	NUM
dti-1305	228	8	m	m	NOUN
dti-1305	228	9	(	(	PUNCT
dti-1305	228	10	girault	girault	VERB
dti-1305	228	11	et	et	PROPN
dti-1305	228	12	al	al	PROPN
dti-1305	228	13	.	.	PROPN
dti-1305	228	14	1997	1997	NUM
dti-1305	228	15	)	)	PUNCT
dti-1305	229	1	nh	nh	PROPN
dti-1305	229	2	s	s	PART
dti-1305	229	3	n	n	CCONJ
dti-1305	229	4	br	br	NOUN
dti-1305	229	5	n	n	NOUN
dti-1305	229	6	h3c	h3c	VERB
dti-1305	229	7	h	h	NOUN
dti-1305	229	8	n	n	ADP
dti-1305	229	9	n	n	PROPN
dti-1305	229	10	h	h	NOUN
dti-1305	230	1	n	n	VERB
dti-1305	230	2	hn	hn	PROPN
dti-1305	230	3	s	s	VERB
dti-1305	230	4	n	n	PRON
dti-1305	230	5	br	br	NOUN
dti-1305	230	6	n	n	NOUN
dti-1305	230	7	ch3	ch3	PROPN
dti-1305	231	1	o	o	NOUN
dti-1305	231	2	o	o	X
dti-1305	231	3	nh	nh	PROPN
dti-1305	232	1	n	n	ADV
dti-1305	232	2	o	o	NOUN
dti-1305	232	3	o	o	NOUN
dti-1305	232	4	17	17	NUM
dti-1305	232	5	,	,	PUNCT
dti-1305	232	6	i50	i50	NOUN
dti-1305	232	7	=	=	PUNCT
dti-1305	232	8	0.25	0.25	NUM
dti-1305	232	9	m	m	NOUN
dti-1305	232	10	(	(	PUNCT
dti-1305	232	11	girault	girault	VERB
dti-1305	232	12	et	et	PROPN
dti-1305	232	13	al	al	PROPN
dti-1305	232	14	.	.	PROPN
dti-1305	232	15	20	20	NUM
dti-1305	232	16	01	01	NUM
dti-1305	232	17	)	)	PUNCT
dti-1305	232	18	figure	figure	NOUN
dti-1305	232	19	6	6	NUM
dti-1305	232	20	.	.	PUNCT
dti-1305	232	21	structures	structure	NOUN
dti-1305	232	22	of	of	ADP
dti-1305	232	23	2	2	NUM
dti-1305	232	24	-	-	PUNCT
dti-1305	232	25	aminodiphenylsulfi	aminodiphenylsulfi	NOUN
dti-1305	232	26	des	de	NOUN
dti-1305	232	27	with	with	ADP
dti-1305	232	28	their	their	PRON
dti-1305	232	29	anti	anti	ADJ
dti-1305	232	30	-	-	ADJ
dti-1305	232	31	tr	tr	VERB
dti-1305	232	32	activities	activity	NOUN
dti-1305	232	33	.	.	PUNCT
dti-1305	233	1	drug	drug	NOUN
dti-1305	233	2	target	target	NOUN
dti-1305	233	3	insights	insight	NOUN
dti-1305	233	4	2007	2007	NUM
dti-1305	233	5	:	:	PUNCT
dti-1305	233	6	2	2	NUM
dti-1305	233	7	139	139	NUM
dti-1305	233	8	target	target	NOUN
dti-1305	233	9	for	for	ADP
dti-1305	233	10	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	233	11	and	and	CCONJ
dti-1305	233	12	antileishmanial	antileishmanial	ADJ
dti-1305	233	13	drug	drug	NOUN
dti-1305	233	14	design	design	NOUN
dti-1305	233	15	40	40	NUM
dti-1305	233	16	-	-	NUM
dti-1305	233	17	fold	fold	ADV
dti-1305	233	18	.	.	PUNCT
dti-1305	234	1	the	the	DET
dti-1305	234	2	most	most	ADV
dti-1305	234	3	potent	potent	ADJ
dti-1305	234	4	compound	compound	NOUN
dti-1305	234	5	synthesized	synthesize	VERB
dti-1305	234	6	from	from	ADP
dti-1305	234	7	this	this	DET
dti-1305	234	8	series	series	NOUN
dti-1305	234	9	was	be	AUX
dti-1305	234	10	the	the	DET
dti-1305	234	11	3	3	NUM
dti-1305	234	12	,	,	PUNCT
dti-1305	234	13	4	4	NUM
dti-1305	234	14	-	-	PUNCT
dti-1305	234	15	dichlorobenzyl	dichlorobenzyl	NOUN
dti-1305	234	16	analog	analog	NOUN
dti-1305	234	17	(	(	PUNCT
dti-1305	234	18	20	20	NUM
dti-1305	234	19	)	)	PUNCT
dti-1305	234	20	(	(	PUNCT
dti-1305	234	21	parveen	parveen	PROPN
dti-1305	234	22	et	et	PROPN
dti-1305	234	23	al	al	PROPN
dti-1305	234	24	.	.	PROPN
dti-1305	234	25	2005	2005	NUM
dti-1305	234	26	)	)	PUNCT
dti-1305	234	27	.	.	PUNCT
dti-1305	235	1	all	all	DET
dti-1305	235	2	analogs	analog	NOUN
dti-1305	235	3	demonstrated	demonstrate	VERB
dti-1305	235	4	strong	strong	ADJ
dti-1305	235	5	inhibition	inhibition	NOUN
dti-1305	235	6	,	,	PUNCT
dti-1305	235	7	some	some	PRON
dti-1305	235	8	in	in	ADP
dti-1305	235	9	lower	low	ADJ
dti-1305	235	10	nm	nm	ADJ
dti-1305	235	11	ranges	range	NOUN
dti-1305	235	12	,	,	PUNCT
dti-1305	235	13	against	against	ADP
dti-1305	235	14	the	the	DET
dti-1305	235	15	blood	blood	NOUN
dti-1305	235	16	stream	stream	NOUN
dti-1305	235	17	form	form	NOUN
dti-1305	235	18	of	of	ADP
dti-1305	235	19	t.	t.	PROPN
dti-1305	235	20	brucei	brucei	PROPN
dti-1305	235	21	.	.	PUNCT
dti-1305	236	1	antiparasitic	antiparasitic	ADJ
dti-1305	236	2	activity	activity	NOUN
dti-1305	236	3	was	be	AUX
dti-1305	236	4	not	not	PART
dti-1305	236	5	solely	solely	ADV
dti-1305	236	6	determined	determine	VERB
dti-1305	236	7	by	by	ADP
dti-1305	236	8	the	the	DET
dti-1305	236	9	inhibition	inhibition	NOUN
dti-1305	236	10	strength	strength	NOUN
dti-1305	236	11	against	against	ADP
dti-1305	236	12	tr	tr	ADP
dti-1305	236	13	;	;	PUNCT
dti-1305	236	14	a	a	DET
dti-1305	236	15	strong	strong	ADJ
dti-1305	236	16	contribution	contribution	NOUN
dti-1305	236	17	from	from	ADP
dti-1305	236	18	hydrophobicity	hydrophobicity	NOUN
dti-1305	236	19	was	be	AUX
dti-1305	236	20	also	also	ADV
dti-1305	236	21	observed	observe	VERB
dti-1305	236	22	.	.	PUNCT
dti-1305	237	1	although	although	SCONJ
dti-1305	237	2	active	active	ADJ
dti-1305	237	3	against	against	ADP
dti-1305	237	4	l.	l.	PROPN
dti-1305	237	5	donovani	donovani	PROPN
dti-1305	237	6	,	,	PUNCT
dti-1305	237	7	none	none	NOUN
dti-1305	237	8	showed	show	VERB
dti-1305	237	9	major	major	ADJ
dti-1305	237	10	improvement	improvement	NOUN
dti-1305	237	11	in	in	ADP
dti-1305	237	12	this	this	DET
dti-1305	237	13	activity	activity	NOUN
dti-1305	237	14	relative	relative	ADJ
dti-1305	237	15	to	to	ADP
dti-1305	237	16	their	their	PRON
dti-1305	237	17	parent	parent	NOUN
dti-1305	237	18	compounds	compound	NOUN
dti-1305	237	19	.	.	PUNCT
dti-1305	238	1	some	some	PRON
dti-1305	238	2	of	of	ADP
dti-1305	238	3	the	the	DET
dti-1305	238	4	analogs	analog	NOUN
dti-1305	238	5	also	also	ADV
dti-1305	238	6	showed	show	VERB
dti-1305	238	7	improved	improved	ADJ
dti-1305	238	8	inhibition	inhibition	NOUN
dti-1305	238	9	against	against	ADP
dti-1305	238	10	the	the	DET
dti-1305	238	11	amastigote	amastigote	NOUN
dti-1305	238	12	stage	stage	NOUN
dti-1305	238	13	of	of	ADP
dti-1305	238	14	t.	t.	PROPN
dti-1305	238	15	cruzi	cruzi	PROPN
dti-1305	238	16	with	with	ADP
dti-1305	238	17	ed50	ed50	PROPN
dti-1305	238	18	values	value	NOUN
dti-1305	238	19	<	<	X
dti-1305	238	20	1	1	NUM
dti-1305	238	21	µm	µm	X
dti-1305	238	22	(	(	PUNCT
dti-1305	238	23	khan	khan	PROPN
dti-1305	238	24	et	et	PROPN
dti-1305	238	25	al	al	PROPN
dti-1305	238	26	.	.	PROPN
dti-1305	238	27	2000	2000	NUM
dti-1305	238	28	;	;	PUNCT
dti-1305	238	29	parveen	parveen	PROPN
dti-1305	238	30	et	et	PROPN
dti-1305	238	31	al	al	PROPN
dti-1305	238	32	.	.	PROPN
dti-1305	238	33	2005	2005	NUM
dti-1305	238	34	)	)	PUNCT
dti-1305	238	35	.	.	PUNCT
dti-1305	239	1	polyamine	polyamine	NOUN
dti-1305	239	2	derivatives	derivative	NOUN
dti-1305	239	3	as	as	SCONJ
dti-1305	239	4	shown	show	VERB
dti-1305	239	5	in	in	ADP
dti-1305	239	6	scheme	scheme	NOUN
dti-1305	239	7	1	1	NUM
dti-1305	239	8	,	,	PUNCT
dti-1305	239	9	the	the	DET
dti-1305	239	10	natural	natural	ADJ
dti-1305	239	11	disulfide	disulfide	NOUN
dti-1305	239	12	substrate	substrate	NOUN
dti-1305	239	13	of	of	ADP
dti-1305	239	14	tr	tr	VERB
dti-1305	239	15	,	,	PUNCT
dti-1305	239	16	t[s]2	t[s]2	NOUN
dti-1305	239	17	,	,	PUNCT
dti-1305	239	18	differs	differ	VERB
dti-1305	239	19	from	from	ADP
dti-1305	239	20	the	the	DET
dti-1305	239	21	analogous	analogous	ADJ
dti-1305	239	22	host	host	NOUN
dti-1305	239	23	’s	’s	PART
dti-1305	239	24	gssg	gssg	VERB
dti-1305	239	25	only	only	ADV
dti-1305	239	26	by	by	ADP
dti-1305	239	27	the	the	DET
dti-1305	239	28	presence	presence	NOUN
dti-1305	239	29	of	of	ADP
dti-1305	239	30	a	a	DET
dti-1305	239	31	spermidine	spermidine	NOUN
dti-1305	239	32	(	(	PUNCT
dti-1305	239	33	a	a	DET
dti-1305	239	34	polyamine	polyamine	NOUN
dti-1305	239	35	)	)	PUNCT
dti-1305	239	36	cross	cross	NOUN
dti-1305	239	37	-	-	NOUN
dti-1305	239	38	link	link	NOUN
dti-1305	239	39	between	between	ADP
dti-1305	239	40	the	the	DET
dti-1305	239	41	two	two	NUM
dti-1305	239	42	glycyl	glycyl	NOUN
dti-1305	239	43	carboxyl	carboxyl	NOUN
dti-1305	239	44	groups	group	NOUN
dti-1305	239	45	.	.	PUNCT
dti-1305	240	1	this	this	DET
dti-1305	240	2	discrimination	discrimination	NOUN
dti-1305	240	3	between	between	ADP
dti-1305	240	4	parasite	parasite	NOUN
dti-1305	240	5	and	and	CCONJ
dti-1305	240	6	host	host	NOUN
dti-1305	240	7	substrate	substrate	NOUN
dti-1305	240	8	served	serve	VERB
dti-1305	240	9	as	as	ADP
dti-1305	240	10	a	a	DET
dti-1305	240	11	criterion	criterion	NOUN
dti-1305	240	12	for	for	ADP
dti-1305	240	13	developing	develop	VERB
dti-1305	240	14	polyamine	polyamine	NOUN
dti-1305	240	15	derivatives	derivative	NOUN
dti-1305	240	16	as	as	ADP
dti-1305	240	17	selective	selective	ADJ
dti-1305	240	18	inhibitors	inhibitor	NOUN
dti-1305	240	19	of	of	ADP
dti-1305	240	20	tr	tr	VERB
dti-1305	240	21	(	(	PUNCT
dti-1305	240	22	o’sullivan	o’sullivan	NOUN
dti-1305	240	23	and	and	CCONJ
dti-1305	240	24	zhau	zhau	NOUN
dti-1305	240	25	,	,	PUNCT
dti-1305	240	26	1995	1995	NUM
dti-1305	240	27	;	;	PUNCT
dti-1305	240	28	o’sullivan	o’sullivan	NOUN
dti-1305	240	29	et	et	PROPN
dti-1305	240	30	al	al	PROPN
dti-1305	240	31	.	.	PROPN
dti-1305	240	32	1996	1996	NUM
dti-1305	240	33	,	,	PUNCT
dti-1305	240	34	1997	1997	NUM
dti-1305	240	35	;	;	PUNCT
dti-1305	240	36	baillet	baillet	NOUN
dti-1305	240	37	et	et	PROPN
dti-1305	240	38	al	al	PROPN
dti-1305	240	39	.	.	PROPN
dti-1305	240	40	1996	1996	NUM
dti-1305	240	41	;	;	PUNCT
dti-1305	240	42	li	li	PROPN
dti-1305	240	43	et	et	PROPN
dti-1305	240	44	al	al	PROPN
dti-1305	240	45	.	.	PROPN
dti-1305	240	46	2001	2001	NUM
dti-1305	240	47	;	;	PUNCT
dti-1305	240	48	bi	bi	PROPN
dti-1305	240	49	et	et	PROPN
dti-1305	240	50	al	al	PROPN
dti-1305	240	51	.	.	PROPN
dti-1305	240	52	2006	2006	NUM
dti-1305	240	53	)	)	PUNCT
dti-1305	240	54	.	.	PUNCT
dti-1305	241	1	this	this	DET
dti-1305	241	2	approach	approach	NOUN
dti-1305	241	3	led	lead	VERB
dti-1305	241	4	to	to	ADP
dti-1305	241	5	the	the	DET
dti-1305	241	6	discovery	discovery	NOUN
dti-1305	241	7	of	of	ADP
dti-1305	241	8	series	series	NOUN
dti-1305	241	9	of	of	ADP
dti-1305	241	10	potent	potent	ADJ
dti-1305	241	11	selective	selective	ADJ
dti-1305	241	12	competitive	competitive	ADJ
dti-1305	241	13	inhibitors	inhibitor	NOUN
dti-1305	241	14	of	of	ADP
dti-1305	241	15	tr	tr	VERB
dti-1305	241	16	,	,	PUNCT
dti-1305	241	17	several	several	ADJ
dti-1305	241	18	selected	select	VERB
dti-1305	241	19	compounds	compound	NOUN
dti-1305	241	20	are	be	AUX
dti-1305	241	21	included	include	VERB
dti-1305	241	22	in	in	ADP
dti-1305	241	23	figure	figure	NOUN
dti-1305	241	24	9	9	NUM
dti-1305	241	25	(	(	PUNCT
dti-1305	241	26	compounds	compound	NOUN
dti-1305	241	27	21	21	NUM
dti-1305	241	28	,	,	PUNCT
dti-1305	241	29	22	22	NUM
dti-1305	241	30	)	)	PUNCT
dti-1305	241	31	.	.	PUNCT
dti-1305	242	1	solid	solid	ADJ
dti-1305	242	2	phase	phase	NOUN
dti-1305	242	3	synthesis	synthesis	NOUN
dti-1305	242	4	approaches	approach	NOUN
dti-1305	242	5	allowed	allow	VERB
dti-1305	242	6	for	for	ADP
dti-1305	242	7	the	the	DET
dti-1305	242	8	expedient	expedient	ADJ
dti-1305	242	9	synthesis	synthesis	NOUN
dti-1305	242	10	of	of	ADP
dti-1305	242	11	polyamine	polyamine	NOUN
dti-1305	242	12	-	-	PUNCT
dti-1305	242	13	based	base	VERB
dti-1305	242	14	focused	focused	ADJ
dti-1305	242	15	libraries	library	NOUN
dti-1305	242	16	as	as	ADP
dti-1305	242	17	potential	potential	ADJ
dti-1305	242	18	tr	tr	NOUN
dti-1305	242	19	inhibitors	inhibitor	NOUN
dti-1305	242	20	.	.	PUNCT
dti-1305	243	1	several	several	ADJ
dti-1305	243	2	potent	potent	ADJ
dti-1305	243	3	inhibitors	inhibitor	NOUN
dti-1305	243	4	were	be	AUX
dti-1305	243	5	identifi	identifi	PROPN
dti-1305	243	6	ed	ed	NOUN
dti-1305	243	7	with	with	ADP
dti-1305	243	8	low	low	ADJ
dti-1305	243	9	nm	nm	ADJ
dti-1305	243	10	activity	activity	NOUN
dti-1305	243	11	(	(	PUNCT
dti-1305	243	12	orain	orain	NOUN
dti-1305	243	13	and	and	CCONJ
dti-1305	243	14	bradley	bradley	PROPN
dti-1305	243	15	,	,	PUNCT
dti-1305	243	16	2001	2001	NUM
dti-1305	243	17	;	;	PUNCT
dti-1305	243	18	de	de	X
dti-1305	243	19	luca	luca	PROPN
dti-1305	243	20	et	et	PROPN
dti-1305	243	21	al	al	PROPN
dti-1305	243	22	.	.	PROPN
dti-1305	243	23	2003	2003	NUM
dti-1305	243	24	)	)	PUNCT
dti-1305	243	25	.	.	PUNCT
dti-1305	244	1	most	most	ADJ
dti-1305	244	2	of	of	ADP
dti-1305	244	3	these	these	DET
dti-1305	244	4	compounds	compound	NOUN
dti-1305	244	5	also	also	ADV
dti-1305	244	6	displayed	display	VERB
dti-1305	244	7	potent	potent	ADJ
dti-1305	244	8	in	in	ADP
dti-1305	244	9	vitro	vitro	X
dti-1305	244	10	antiparasitic	antiparasitic	ADJ
dti-1305	244	11	activity	activity	NOUN
dti-1305	244	12	against	against	ADP
dti-1305	244	13	t.	t.	PROPN
dti-1305	244	14	brucei	brucei	NOUN
dti-1305	244	15	with	with	ADP
dti-1305	244	16	ed50	ed50	PROPN
dti-1305	244	17	values	value	NOUN
dti-1305	244	18	<	<	X
dti-1305	244	19	1	1	NUM
dti-1305	244	20	µm	µm	X
dti-1305	244	21	(	(	PUNCT
dti-1305	244	22	o’sullivan	o’sullivan	NOUN
dti-1305	244	23	et	et	NOUN
dti-1305	244	24	al	al	PROPN
dti-1305	244	25	.	.	PROPN
dti-1305	244	26	1997	1997	NUM
dti-1305	244	27	;	;	PUNCT
dti-1305	244	28	li	li	PROPN
dti-1305	244	29	et	et	PROPN
dti-1305	244	30	al	al	PROPN
dti-1305	244	31	.	.	PROPN
dti-1305	244	32	2001	2001	NUM
dti-1305	244	33	;	;	PUNCT
dti-1305	244	34	bi	bi	PROPN
dti-1305	244	35	et	et	PROPN
dti-1305	244	36	al	al	PROPN
dti-1305	244	37	.	.	PROPN
dti-1305	244	38	2006	2006	NUM
dti-1305	244	39	)	)	PUNCT
dti-1305	244	40	.	.	PUNCT
dti-1305	245	1	these	these	DET
dti-1305	245	2	preliminary	preliminary	ADJ
dti-1305	245	3	antiparasitic	antiparasitic	ADJ
dti-1305	245	4	activity	activity	NOUN
dti-1305	245	5	in	in	ADP
dti-1305	245	6	vitro	vitro	X
dti-1305	245	7	are	be	AUX
dti-1305	245	8	suggestive	suggestive	ADJ
dti-1305	245	9	of	of	ADP
dti-1305	245	10	their	their	PRON
dti-1305	245	11	tr	tr	NOUN
dti-1305	245	12	involvement	involvement	NOUN
dti-1305	245	13	although	although	SCONJ
dti-1305	245	14	well	well	ADV
dti-1305	245	15	correlation	correlation	NOUN
dti-1305	245	16	between	between	ADP
dti-1305	245	17	tr	tr	VERB
dti-1305	245	18	-	-	PUNCT
dti-1305	245	19	inhibition	inhibition	NOUN
dti-1305	245	20	and	and	CCONJ
dti-1305	245	21	trypanocidal	trypanocidal	ADJ
dti-1305	245	22	activity	activity	NOUN
dti-1305	245	23	were	be	AUX
dti-1305	245	24	not	not	PART
dti-1305	245	25	evident	evident	ADJ
dti-1305	245	26	.	.	PUNCT
dti-1305	246	1	bisbenzylisoquinoline	bisbenzylisoquinoline	NOUN
dti-1305	246	2	alkaloids	alkaloid	VERB
dti-1305	246	3	the	the	DET
dti-1305	246	4	bisbenzylisoquinoline	bisbenzylisoquinoline	NOUN
dti-1305	246	5	alkaloids	alkaloid	NOUN
dti-1305	246	6	were	be	AUX
dti-1305	246	7	also	also	ADV
dti-1305	246	8	shown	show	VERB
dti-1305	246	9	to	to	PART
dti-1305	246	10	be	be	AUX
dti-1305	246	11	potent	potent	ADJ
dti-1305	246	12	inhibitors	inhibitor	NOUN
dti-1305	246	13	of	of	ADP
dti-1305	246	14	tr	tr	VERB
dti-1305	246	15	and	and	CCONJ
dti-1305	246	16	trypanocidal	trypanocidal	ADJ
dti-1305	246	17	agents	agent	NOUN
dti-1305	246	18	(	(	PUNCT
dti-1305	246	19	fournet	fournet	PROPN
dti-1305	246	20	et	et	PROPN
dti-1305	246	21	al	al	PROPN
dti-1305	246	22	.	.	PROPN
dti-1305	246	23	1998	1998	NUM
dti-1305	246	24	,	,	PUNCT
dti-1305	246	25	2000	2000	NUM
dti-1305	246	26	)	)	PUNCT
dti-1305	246	27	.	.	PUNCT
dti-1305	247	1	six	six	NUM
dti-1305	247	2	of	of	ADP
dti-1305	247	3	the	the	DET
dti-1305	247	4	alkaloids	alkaloid	NOUN
dti-1305	247	5	evaluated	evaluate	VERB
dti-1305	247	6	displayed	display	VERB
dti-1305	247	7	potent	potent	ADJ
dti-1305	247	8	trypanocidal	trypanocidal	ADJ
dti-1305	247	9	activity	activity	NOUN
dti-1305	247	10	in	in	ADP
dti-1305	247	11	vitro	vitro	X
dti-1305	247	12	against	against	ADP
dti-1305	247	13	t.	t.	PROPN
dti-1305	247	14	cruzi	cruzi	PROPN
dti-1305	247	15	with	with	ADP
dti-1305	247	16	ed50	ed50	PROPN
dti-1305	247	17	values	value	NOUN
dti-1305	247	18	<	<	X
dti-1305	247	19	100	100	NUM
dti-1305	247	20	µm	µm	NOUN
dti-1305	247	21	.	.	PUNCT
dti-1305	248	1	the	the	DET
dti-1305	248	2	best	good	ADJ
dti-1305	248	3	tr	tr	NOUN
dti-1305	248	4	inhibitor	inhibitor	NOUN
dti-1305	248	5	,	,	PUNCT
dti-1305	248	6	cepharanthine	cepharanthine	NOUN
dti-1305	248	7	figure	figure	NOUN
dti-1305	248	8	8	8	NUM
dti-1305	248	9	.	.	PUNCT
dti-1305	249	1	compound	compound	NOUN
dti-1305	249	2	18	18	NUM
dti-1305	249	3	docked	dock	VERB
dti-1305	249	4	into	into	ADP
dti-1305	249	5	active	active	ADJ
dti-1305	249	6	site	site	NOUN
dti-1305	249	7	of	of	ADP
dti-1305	249	8	tr	tr	PUNCT
dti-1305	249	9	to	to	PART
dti-1305	249	10	show	show	VERB
dti-1305	249	11	major	major	ADJ
dti-1305	249	12	interactions	interaction	NOUN
dti-1305	249	13	(	(	PUNCT
dti-1305	249	14	taken	take	VERB
dti-1305	249	15	from	from	ADP
dti-1305	249	16	austin	austin	PROPN
dti-1305	249	17	et	et	PROPN
dti-1305	249	18	al	al	PROPN
dti-1305	249	19	.	.	PROPN
dti-1305	249	20	1999	1999	NUM
dti-1305	249	21	)	)	PUNCT
dti-1305	249	22	.	.	PUNCT
dti-1305	250	1	figure	figure	NOUN
dti-1305	250	2	9	9	NUM
dti-1305	250	3	.	.	PUNCT
dti-1305	250	4	structures	structure	NOUN
dti-1305	250	5	and	and	CCONJ
dti-1305	250	6	trypanothione	trypanothione	NOUN
dti-1305	250	7	reductase	reductase	NOUN
dti-1305	250	8	inhibitory	inhibitory	ADJ
dti-1305	250	9	activities	activity	NOUN
dti-1305	250	10	of	of	ADP
dti-1305	250	11	polyamine	polyamine	NOUN
dti-1305	250	12	derivatives	derivative	NOUN
dti-1305	250	13	.	.	PUNCT
dti-1305	251	1	n	n	CCONJ
dti-1305	251	2	n	n	CCONJ
dti-1305	251	3	n	n	CCONJ
dti-1305	251	4	nh	nh	X
dti-1305	251	5	ph	ph	ADJ
dti-1305	251	6	ph	ph	ADJ
dti-1305	251	7	ph	ph	ADJ
dti-1305	251	8	ph	ph	NOUN
dti-1305	251	9	ph	ph	PROPN
dti-1305	251	10	21	21	NUM
dti-1305	251	11	,	,	PUNCT
dti-1305	251	12	ki	ki	PROPN
dti-1305	251	13	=	=	PUNCT
dti-1305	251	14	151	151	NUM
dti-1305	251	15	nm	nm	NOUN
dti-1305	251	16	(	(	PUNCT
dti-1305	251	17	li	li	PROPN
dti-1305	251	18	et	et	PROPN
dti-1305	251	19	al	al	PROPN
dti-1305	251	20	.	.	PROPN
dti-1305	251	21	20	20	NUM
dti-1305	251	22	01	01	NUM
dti-1305	251	23	)	)	PUNCT
dti-1305	252	1	r	r	NOUN
dti-1305	252	2	n	n	NUM
dti-1305	252	3	h	h	NOUN
dti-1305	252	4	n	n	ADP
dti-1305	252	5	h	h	NOUN
dti-1305	252	6	n	n	ADP
dti-1305	252	7	h	h	NOUN
dti-1305	252	8	n	n	ADP
dti-1305	252	9	h	h	NOUN
dti-1305	252	10	n	n	ADP
dti-1305	252	11	h	h	NOUN
dti-1305	252	12	n	n	ADP
dti-1305	252	13	h	h	NOUN
dti-1305	252	14	n	n	ADP
dti-1305	252	15	h	h	NOUN
dti-1305	253	1	n	n	NOUN
dti-1305	253	2	h	h	NOUN
dti-1305	253	3	r	r	PROPN
dti-1305	253	4	nh	nh	PROPN
dti-1305	253	5	nh	nh	PROPN
dti-1305	253	6	nh	nh	PROPN
dti-1305	253	7	nh	nh	PROPN
dti-1305	253	8	22	22	NUM
dti-1305	253	9	,	,	PUNCT
dti-1305	253	10	r	r	NOUN
dti-1305	253	11	=	=	SYM
dti-1305	253	12	diphenylpropyl	diphenylpropyl	ADJ
dti-1305	253	13	;	;	PUNCT
dti-1305	253	14	i50	i50	PROPN
dti-1305	253	15	=	=	SYM
dti-1305	253	16	950	950	NUM
dti-1305	253	17	nm	nm	NOUN
dti-1305	253	18	(	(	PUNCT
dti-1305	253	19	bi	bi	NOUN
dti-1305	253	20	et	et	PROPN
dti-1305	253	21	al	al	PROPN
dti-1305	253	22	.	.	PROPN
dti-1305	253	23	2006	2006	NUM
dti-1305	253	24	)	)	PUNCT
dti-1305	253	25	5	5	NUM
dti-1305	253	26	n	n	NUM
dti-1305	253	27	o	o	NOUN
dti-1305	254	1	o	o	X
dti-1305	254	2	o	o	X
dti-1305	254	3	meo	meo	X
dti-1305	254	4	o	o	NOUN
dti-1305	254	5	n	n	NOUN
dti-1305	255	1	ch3h	ch3h	NOUN
dti-1305	255	2	h	h	NOUN
dti-1305	255	3	h3c	h3c	VERB
dti-1305	255	4	ome	ome	PROPN
dti-1305	255	5	23	23	NUM
dti-1305	255	6	,	,	PUNCT
dti-1305	255	7	i50	i50	NOUN
dti-1305	255	8	=	=	SYM
dti-1305	255	9	15	15	NUM
dti-1305	255	10	m	m	NOUN
dti-1305	255	11	(	(	PUNCT
dti-1305	255	12	fournet	fournet	PROPN
dti-1305	255	13	et	et	PROPN
dti-1305	255	14	al	al	PROPN
dti-1305	255	15	.	.	PROPN
dti-1305	255	16	1998	1998	NUM
dti-1305	255	17	)	)	PUNCT
dti-1305	255	18	figure	figure	NOUN
dti-1305	255	19	10	10	NUM
dti-1305	255	20	.	.	PUNCT
dti-1305	256	1	bisbenzyleisoquinoline	bisbenzyleisoquinoline	PROPN
dti-1305	256	2	alkaloid	alkaloid	PROPN
dti-1305	256	3	.	.	PUNCT
dti-1305	256	4	drug	drug	NOUN
dti-1305	256	5	target	target	NOUN
dti-1305	256	6	insights	insight	NOUN
dti-1305	256	7	2007	2007	NUM
dti-1305	256	8	:	:	PUNCT
dti-1305	256	9	2	2	NUM
dti-1305	256	10	140	140	NUM
dti-1305	256	11	khan	khan	NOUN
dti-1305	256	12	(	(	PUNCT
dti-1305	256	13	23	23	NUM
dti-1305	256	14	)	)	PUNCT
dti-1305	256	15	,	,	PUNCT
dti-1305	256	16	had	have	VERB
dti-1305	256	17	an	an	DET
dti-1305	256	18	i50	i50	NOUN
dti-1305	256	19	value	value	NOUN
dti-1305	256	20	of	of	ADP
dti-1305	256	21	15	15	NUM
dti-1305	256	22	µm	µm	ADP
dti-1305	256	23	which	which	PRON
dti-1305	256	24	is	be	AUX
dti-1305	256	25	the	the	DET
dti-1305	256	26	same	same	ADJ
dti-1305	256	27	order	order	NOUN
dti-1305	256	28	of	of	ADP
dti-1305	256	29	magnitude	magnitude	NOUN
dti-1305	256	30	as	as	ADP
dti-1305	256	31	its	its	PRON
dti-1305	256	32	ed50	ed50	PROPN
dti-1305	256	33	against	against	ADP
dti-1305	256	34	the	the	DET
dti-1305	256	35	parasites	parasite	NOUN
dti-1305	256	36	,	,	PUNCT
dti-1305	256	37	suggesting	suggest	VERB
dti-1305	256	38	that	that	SCONJ
dti-1305	256	39	inhibition	inhibition	NOUN
dti-1305	256	40	of	of	ADP
dti-1305	256	41	tr	tr	PRON
dti-1305	256	42	could	could	AUX
dti-1305	256	43	be	be	AUX
dti-1305	256	44	the	the	DET
dti-1305	256	45	mechanism	mechanism	NOUN
dti-1305	256	46	of	of	ADP
dti-1305	256	47	their	their	PRON
dti-1305	256	48	trypanocidal	trypanocidal	ADJ
dti-1305	256	49	activities	activity	NOUN
dti-1305	256	50	.	.	PUNCT
dti-1305	257	1	natural	natural	ADJ
dti-1305	257	2	products	product	NOUN
dti-1305	257	3	natural	natural	ADJ
dti-1305	257	4	products	product	NOUN
dti-1305	257	5	may	may	AUX
dti-1305	257	6	be	be	AUX
dti-1305	257	7	considered	consider	VERB
dti-1305	257	8	as	as	ADP
dti-1305	257	9	“	"	PUNCT
dti-1305	257	10	nature	nature	X
dti-1305	257	11	’s	’s	PART
dti-1305	257	12	medicine	medicine	PROPN
dti-1305	257	13	chest	chest	NOUN
dti-1305	257	14	”	"	PUNCT
dti-1305	257	15	and	and	CCONJ
dti-1305	257	16	have	have	AUX
dti-1305	257	17	served	serve	VERB
dti-1305	257	18	as	as	ADP
dti-1305	257	19	a	a	DET
dti-1305	257	20	potential	potential	ADJ
dti-1305	257	21	source	source	NOUN
dti-1305	257	22	of	of	ADP
dti-1305	257	23	tr	tr	NOUN
dti-1305	257	24	-	-	NOUN
dti-1305	257	25	inhibitors	inhibitor	NOUN
dti-1305	257	26	.	.	PUNCT
dti-1305	258	1	the	the	DET
dti-1305	258	2	natural	natural	ADJ
dti-1305	258	3	antihypertensive	antihypertensive	ADJ
dti-1305	258	4	agent	agent	NOUN
dti-1305	258	5	,	,	PUNCT
dti-1305	258	6	kukoamine	kukoamine	NOUN
dti-1305	258	7	a	a	DET
dti-1305	258	8	(	(	PUNCT
dti-1305	258	9	24	24	NUM
dti-1305	258	10	)	)	PUNCT
dti-1305	258	11	,	,	PUNCT
dti-1305	258	12	a	a	DET
dti-1305	258	13	bis	bis	ADJ
dti-1305	258	14	(	(	PUNCT
dti-1305	258	15	trihydrocinnamoyl	trihydrocinnamoyl	NOUN
dti-1305	258	16	)	)	PUNCT
dti-1305	258	17	spermidine	spermidine	NOUN
dti-1305	258	18	derivative	derivative	ADJ
dti-1305	258	19	,	,	PUNCT
dti-1305	258	20	fi	fi	NOUN
dti-1305	258	21	rst	rst	PROPN
dti-1305	258	22	isolated	isolate	VERB
dti-1305	258	23	from	from	ADP
dti-1305	258	24	lycium	lycium	NOUN
dti-1305	258	25	chinense	chinense	NOUN
dti-1305	258	26	,	,	PUNCT
dti-1305	258	27	was	be	AUX
dti-1305	258	28	identifi	identifi	NOUN
dti-1305	258	29	ed	ed	NOUN
dti-1305	258	30	as	as	ADP
dti-1305	258	31	a	a	DET
dti-1305	258	32	mixed	mixed	ADJ
dti-1305	258	33	type	type	NOUN
dti-1305	258	34	of	of	ADP
dti-1305	258	35	inhibitor	inhibitor	NOUN
dti-1305	258	36	of	of	ADP
dti-1305	258	37	tr	tr	VERB
dti-1305	258	38	(	(	PUNCT
dti-1305	258	39	ponasik	ponasik	NOUN
dti-1305	258	40	et	et	PROPN
dti-1305	258	41	al	al	PROPN
dti-1305	258	42	.	.	PROPN
dti-1305	258	43	1995	1995	NUM
dti-1305	258	44	)	)	PUNCT
dti-1305	258	45	.	.	PUNCT
dti-1305	259	1	virtual	virtual	ADJ
dti-1305	259	2	screening	screening	NOUN
dti-1305	259	3	of	of	ADP
dti-1305	259	4	a	a	DET
dti-1305	259	5	large	large	ADJ
dti-1305	259	6	number	number	NOUN
dti-1305	259	7	of	of	ADP
dti-1305	259	8	chemical	chemical	NOUN
dti-1305	259	9	databases	database	NOUN
dti-1305	259	10	,	,	PUNCT
dti-1305	259	11	using	use	VERB
dti-1305	259	12	the	the	DET
dti-1305	259	13	tr	tr	PUNCT
dti-1305	259	14	active	active	ADJ
dti-1305	259	15	site	site	NOUN
dti-1305	259	16	as	as	ADP
dti-1305	259	17	the	the	DET
dti-1305	259	18	targeted	target	VERB
dti-1305	259	19	template	template	NOUN
dti-1305	259	20	,	,	PUNCT
dti-1305	259	21	identified	identify	VERB
dti-1305	259	22	the	the	DET
dti-1305	259	23	natural	natural	ADJ
dti-1305	259	24	spermine	spermine	NOUN
dti-1305	259	25	-	-	PUNCT
dti-1305	259	26	based	base	VERB
dti-1305	259	27	macrocyclic	macrocyclic	NOUN
dti-1305	259	28	alkaloid	alkaloid	PROPN
dti-1305	259	29	lunarin	lunarin	NOUN
dti-1305	259	30	(	(	PUNCT
dti-1305	259	31	25	25	NUM
dti-1305	259	32	)	)	PUNCT
dti-1305	259	33	(	(	PUNCT
dti-1305	259	34	originally	originally	ADV
dti-1305	259	35	isolated	isolate	VERB
dti-1305	259	36	from	from	ADP
dti-1305	259	37	lunaria	lunaria	PROPN
dti-1305	259	38	biennis	bienni	NOUN
dti-1305	259	39	)	)	PUNCT
dti-1305	259	40	as	as	ADP
dti-1305	259	41	tr	tr	VERB
dti-1305	259	42	-	-	NOUN
dti-1305	259	43	inhibitor	inhibitor	NOUN
dti-1305	259	44	,	,	PUNCT
dti-1305	259	45	which	which	PRON
dti-1305	259	46	was	be	AUX
dti-1305	259	47	shown	show	VERB
dti-1305	259	48	to	to	PART
dti-1305	259	49	inhibit	inhibit	VERB
dti-1305	259	50	the	the	DET
dti-1305	259	51	enzyme	enzyme	NOUN
dti-1305	259	52	in	in	ADP
dti-1305	259	53	a	a	DET
dti-1305	259	54	time	time	NOUN
dti-1305	259	55	-	-	PUNCT
dti-1305	259	56	dependent	dependent	ADJ
dti-1305	259	57	manner	manner	NOUN
dti-1305	259	58	(	(	PUNCT
dti-1305	259	59	bond	bond	NOUN
dti-1305	259	60	et	et	PROPN
dti-1305	259	61	al	al	PROPN
dti-1305	259	62	.	.	PROPN
dti-1305	259	63	1999	1999	NUM
dti-1305	259	64	)	)	PUNCT
dti-1305	259	65	.	.	PUNCT
dti-1305	260	1	further	further	ADJ
dti-1305	260	2	investigation	investigation	NOUN
dti-1305	260	3	with	with	ADP
dti-1305	260	4	synthetic	synthetic	ADJ
dti-1305	260	5	derivatives	derivative	NOUN
dti-1305	260	6	confi	confi	VERB
dti-1305	260	7	rmed	rme	VERB
dti-1305	260	8	the	the	DET
dti-1305	260	9	importance	importance	NOUN
dti-1305	260	10	of	of	ADP
dti-1305	260	11	the	the	DET
dti-1305	260	12	unique	unique	ADJ
dti-1305	260	13	structure	structure	NOUN
dti-1305	260	14	of	of	ADP
dti-1305	260	15	the	the	DET
dti-1305	260	16	tricyclic	tricyclic	PROPN
dti-1305	260	17	core	core	NOUN
dti-1305	260	18	as	as	ADP
dti-1305	260	19	a	a	DET
dti-1305	260	20	motif	motif	NOUN
dti-1305	260	21	for	for	ADP
dti-1305	260	22	inhibitor	inhibitor	NOUN
dti-1305	260	23	design	design	NOUN
dti-1305	260	24	and	and	CCONJ
dti-1305	260	25	revealed	reveal	VERB
dti-1305	260	26	that	that	SCONJ
dti-1305	260	27	the	the	DET
dti-1305	260	28	non	non	ADJ
dti-1305	260	29	-	-	ADJ
dti-1305	260	30	natural	natural	ADJ
dti-1305	260	31	enantiomer	enantiomer	NOUN
dti-1305	260	32	may	may	AUX
dti-1305	260	33	be	be	AUX
dti-1305	260	34	a	a	DET
dti-1305	260	35	more	more	ADV
dti-1305	260	36	suitable	suitable	ADJ
dti-1305	260	37	scaffold	scaffold	NOUN
dti-1305	260	38	upon	upon	SCONJ
dti-1305	260	39	which	which	PRON
dti-1305	260	40	thiophilic	thiophilic	NOUN
dti-1305	260	41	groups	group	NOUN
dti-1305	260	42	may	may	AUX
dti-1305	260	43	be	be	AUX
dti-1305	260	44	presented	present	VERB
dti-1305	260	45	(	(	PUNCT
dti-1305	260	46	hamilton	hamilton	PROPN
dti-1305	260	47	et	et	PROPN
dti-1305	260	48	al	al	PROPN
dti-1305	260	49	.	.	PROPN
dti-1305	260	50	2006	2006	NUM
dti-1305	260	51	)	)	PUNCT
dti-1305	260	52	.	.	PUNCT
dti-1305	261	1	ajoen	ajoen	PROPN
dti-1305	261	2	(	(	PUNCT
dti-1305	261	3	26	26	NUM
dti-1305	261	4	)	)	PUNCT
dti-1305	261	5	a	a	DET
dti-1305	261	6	garlic	garlic	ADJ
dti-1305	261	7	derived	derive	VERB
dti-1305	261	8	natural	natural	ADJ
dti-1305	261	9	sulfur	sulfur	NOUN
dti-1305	261	10	-	-	PUNCT
dti-1305	261	11	containing	contain	VERB
dti-1305	261	12	compound	compound	NOUN
dti-1305	261	13	was	be	AUX
dti-1305	261	14	established	establish	VERB
dti-1305	261	15	as	as	ADP
dti-1305	261	16	an	an	DET
dti-1305	261	17	irreversible	irreversible	ADJ
dti-1305	261	18	inhibitor	inhibitor	NOUN
dti-1305	261	19	and	and	CCONJ
dti-1305	261	20	subversive	subversive	ADJ
dti-1305	261	21	substrate	substrate	NOUN
dti-1305	261	22	of	of	ADP
dti-1305	261	23	both	both	DET
dti-1305	261	24	tr	tr	NOUN
dti-1305	261	25	and	and	CCONJ
dti-1305	261	26	gr	gr	PROPN
dti-1305	261	27	(	(	PUNCT
dti-1305	261	28	gallwitz	gallwitz	PROPN
dti-1305	261	29	et	et	PROPN
dti-1305	261	30	al	al	PROPN
dti-1305	261	31	.	.	PROPN
dti-1305	261	32	1999	1999	NUM
dti-1305	261	33	)	)	PUNCT
dti-1305	261	34	.	.	PUNCT
dti-1305	262	1	most	most	ADJ
dti-1305	262	2	of	of	ADP
dti-1305	262	3	these	these	DET
dti-1305	262	4	natural	natural	ADJ
dti-1305	262	5	products	product	NOUN
dti-1305	262	6	also	also	ADV
dti-1305	262	7	inhibited	inhibit	VERB
dti-1305	262	8	the	the	DET
dti-1305	262	9	parasites	parasite	NOUN
dti-1305	262	10	in	in	ADP
dti-1305	262	11	vitro	vitro	ADJ
dti-1305	262	12	in	in	ADP
dti-1305	262	13	one	one	NUM
dti-1305	262	14	way	way	NOUN
dti-1305	262	15	or	or	CCONJ
dti-1305	262	16	another	another	PRON
dti-1305	262	17	.	.	PUNCT
dti-1305	263	1	irreversible	irreversible	ADJ
dti-1305	263	2	inhibitors	inhibitor	NOUN
dti-1305	263	3	the	the	DET
dti-1305	263	4	anticancer	anticancer	NOUN
dti-1305	263	5	nitrosourea	nitrosourea	ADP
dti-1305	263	6	drug	drug	PROPN
dti-1305	263	7	carmustin	carmustin	NOUN
dti-1305	263	8	was	be	AUX
dti-1305	263	9	the	the	DET
dti-1305	263	10	fi	fi	NOUN
dti-1305	263	11	rst	rst	PROPN
dti-1305	263	12	ligand	ligand	NOUN
dti-1305	263	13	to	to	PART
dti-1305	263	14	display	display	VERB
dti-1305	263	15	irreversible	irreversible	ADJ
dti-1305	263	16	inactivation	inactivation	NOUN
dti-1305	263	17	of	of	ADP
dti-1305	263	18	tr	tr	VERB
dti-1305	263	19	,	,	PUNCT
dti-1305	263	20	but	but	CCONJ
dti-1305	263	21	non	non	ADJ
dti-1305	263	22	-	-	ADJ
dti-1305	263	23	specifi	specifi	NOUN
dti-1305	263	24	cally	cally	ADV
dti-1305	263	25	as	as	ADP
dti-1305	263	26	also	also	ADV
dti-1305	263	27	inactivated	inactivated	ADJ
dti-1305	263	28	hgr	hgr	VERB
dti-1305	263	29	,	,	PUNCT
dti-1305	263	30	by	by	ADP
dti-1305	263	31	carbamoylating	carbamoylate	VERB
dti-1305	263	32	an	an	DET
dti-1305	263	33	active	active	ADJ
dti-1305	263	34	site	site	NOUN
dti-1305	263	35	cystinyl	cystinyl	NOUN
dti-1305	263	36	residue	residue	NOUN
dti-1305	263	37	,	,	PUNCT
dti-1305	263	38	which	which	PRON
dti-1305	263	39	becomes	become	VERB
dti-1305	263	40	accessible	accessible	ADJ
dti-1305	263	41	after	after	ADP
dti-1305	263	42	being	be	AUX
dti-1305	263	43	reduced	reduce	VERB
dti-1305	263	44	by	by	ADP
dti-1305	263	45	nadph	nadph	PROPN
dti-1305	263	46	(	(	PUNCT
dti-1305	263	47	schirmer	schirmer	PROPN
dti-1305	263	48	et	et	PROPN
dti-1305	263	49	al	al	PROPN
dti-1305	263	50	.	.	PROPN
dti-1305	263	51	1995	1995	NUM
dti-1305	263	52	)	)	PUNCT
dti-1305	263	53	.	.	PUNCT
dti-1305	264	1	ajoen	ajoen	PROPN
dti-1305	264	2	(	(	PUNCT
dti-1305	264	3	26	26	NUM
dti-1305	264	4	)	)	PUNCT
dti-1305	264	5	,	,	PUNCT
dti-1305	264	6	as	as	SCONJ
dti-1305	264	7	previously	previously	ADV
dti-1305	264	8	mentioned	mention	VERB
dti-1305	264	9	as	as	ADP
dti-1305	264	10	a	a	DET
dti-1305	264	11	natural	natural	ADJ
dti-1305	264	12	product	product	NOUN
dti-1305	264	13	inhibitor	inhibitor	NOUN
dti-1305	264	14	,	,	PUNCT
dti-1305	264	15	is	be	AUX
dti-1305	264	16	an	an	DET
dti-1305	264	17	irreversible	irreversible	ADJ
dti-1305	264	18	non	non	ADJ
dti-1305	264	19	-	-	ADJ
dti-1305	264	20	specifi	specifi	ADJ
dti-1305	264	21	c	c	PROPN
dti-1305	264	22	inhibitor	inhibitor	NOUN
dti-1305	264	23	of	of	ADP
dti-1305	264	24	tr	tr	VERB
dti-1305	264	25	(	(	PUNCT
dti-1305	264	26	gallwitz	gallwitz	PROPN
dti-1305	264	27	et	et	PROPN
dti-1305	264	28	al	al	PROPN
dti-1305	264	29	.	.	PROPN
dti-1305	264	30	1999	1999	NUM
dti-1305	264	31	)	)	PUNCT
dti-1305	264	32	.	.	PUNCT
dti-1305	265	1	the	the	DET
dti-1305	265	2	fi	fi	NOUN
dti-1305	265	3	rst	rst	PROPN
dti-1305	265	4	rationally	rationally	ADV
dti-1305	265	5	designed	design	VERB
dti-1305	265	6	and	and	CCONJ
dti-1305	265	7	selective	selective	ADJ
dti-1305	265	8	irreversible	irreversible	ADJ
dti-1305	265	9	inhibitors	inhibitor	NOUN
dti-1305	265	10	of	of	ADP
dti-1305	265	11	tr	tr	VERB
dti-1305	265	12	include	include	VERB
dti-1305	265	13	the	the	DET
dti-1305	265	14	pt	pt	NOUN
dti-1305	265	15	-	-	PUNCT
dti-1305	265	16	complexes	complex	NOUN
dti-1305	265	17	of	of	ADP
dti-1305	265	18	terpyridine	terpyridine	NOUN
dti-1305	265	19	derivatives	derivative	NOUN
dti-1305	265	20	(	(	PUNCT
dti-1305	265	21	e.g.	e.g.	ADV
dti-1305	265	22	27	27	NUM
dti-1305	265	23	)	)	PUNCT
dti-1305	265	24	,	,	PUNCT
dti-1305	265	25	which	which	PRON
dti-1305	265	26	inhibit	inhibit	VERB
dti-1305	265	27	the	the	DET
dti-1305	265	28	reduced	reduce	VERB
dti-1305	265	29	tr	tr	VERB
dti-1305	265	30	,	,	PUNCT
dti-1305	265	31	presumably	presumably	ADV
dti-1305	265	32	through	through	ADP
dti-1305	265	33	occupying	occupy	VERB
dti-1305	265	34	the	the	DET
dti-1305	265	35	cys52	cys52	NOUN
dti-1305	265	36	by	by	ADP
dti-1305	265	37	replacing	replace	VERB
dti-1305	265	38	its	its	PRON
dti-1305	265	39	fourth	fourth	ADJ
dti-1305	265	40	pyridine	pyridine	ADJ
dti-1305	265	41	ligand	ligand	NOUN
dti-1305	265	42	(	(	PUNCT
dti-1305	265	43	bonse	bonse	NOUN
dti-1305	265	44	et	et	PROPN
dti-1305	265	45	al	al	PROPN
dti-1305	265	46	.	.	PROPN
dti-1305	265	47	2000	2000	NUM
dti-1305	265	48	)	)	PUNCT
dti-1305	265	49	.	.	PUNCT
dti-1305	266	1	coupling	couple	VERB
dti-1305	266	2	the	the	DET
dti-1305	266	3	irreversible	irreversible	ADJ
dti-1305	266	4	ligand	ligand	NOUN
dti-1305	266	5	(	(	PUNCT
dti-1305	266	6	terpyridine)pt2	terpyridine)pt2	NOUN
dti-1305	266	7	+	+	SYM
dti-1305	266	8	complex	complex	ADJ
dti-1305	266	9	with	with	ADP
dti-1305	266	10	an	an	DET
dti-1305	266	11	9	9	NUM
dti-1305	266	12	-	-	PUNCT
dti-1305	266	13	aminoacridine	aminoacridine	NOUN
dti-1305	266	14	derivative	derivative	NOUN
dti-1305	266	15	(	(	PUNCT
dti-1305	266	16	a	a	DET
dti-1305	266	17	competitive	competitive	ADJ
dti-1305	266	18	inhibitor	inhibitor	NOUN
dti-1305	266	19	)	)	PUNCT
dti-1305	266	20	furnished	furnish	VERB
dti-1305	266	21	mixed	mixed	ADJ
dti-1305	266	22	-	-	PUNCT
dti-1305	266	23	type	type	NOUN
dti-1305	266	24	inhibitors	inhibitor	NOUN
dti-1305	266	25	(	(	PUNCT
dti-1305	266	26	e.g.	e.g.	ADV
dti-1305	266	27	28	28	NUM
dti-1305	266	28	)	)	PUNCT
dti-1305	266	29	(	(	PUNCT
dti-1305	266	30	inhoff	inhoff	NOUN
dti-1305	266	31	et	et	PROPN
dti-1305	266	32	al	al	PROPN
dti-1305	266	33	.	.	PROPN
dti-1305	266	34	2002	2002	NUM
dti-1305	266	35	)	)	PUNCT
dti-1305	266	36	.	.	PUNCT
dti-1305	267	1	an	an	DET
dti-1305	267	2	important	important	ADJ
dti-1305	267	3	advancement	advancement	NOUN
dti-1305	267	4	was	be	AUX
dti-1305	267	5	made	make	VERB
dti-1305	267	6	with	with	ADP
dti-1305	267	7	the	the	DET
dti-1305	267	8	quinacrine	quinacrine	ADJ
dti-1305	267	9	mustard	mustard	NOUN
dti-1305	267	10	(	(	PUNCT
dti-1305	267	11	29	29	NUM
dti-1305	267	12	)	)	PUNCT
dti-1305	267	13	,	,	PUNCT
dti-1305	267	14	which	which	PRON
dti-1305	267	15	was	be	AUX
dti-1305	267	16	shown	show	VERB
dti-1305	267	17	to	to	PART
dti-1305	267	18	selectively	selectively	VERB
dti-1305	267	19	and	and	CCONJ
dti-1305	267	20	irreversibly	irreversibly	ADV
dti-1305	267	21	inactivate	inactivate	VERB
dti-1305	267	22	tr	tr	PUNCT
dti-1305	267	23	in	in	ADP
dti-1305	267	24	a	a	DET
dti-1305	267	25	time	time	NOUN
dti-1305	267	26	-	-	PUNCT
dti-1305	267	27	dependent	dependent	ADJ
dti-1305	267	28	manner	manner	NOUN
dti-1305	267	29	with	with	ADP
dti-1305	267	30	a	a	DET
dti-1305	267	31	stoichiometry	stoichiometry	NOUN
dti-1305	267	32	of	of	ADP
dti-1305	267	33	two	two	NUM
dti-1305	267	34	inhibitors	inhibitor	NOUN
dti-1305	267	35	bound	bind	VERB
dti-1305	267	36	per	per	ADP
dti-1305	267	37	monomer	monomer	NOUN
dti-1305	267	38	.	.	PUNCT
dti-1305	268	1	the	the	DET
dti-1305	268	2	rate	rate	NOUN
dti-1305	268	3	of	of	ADP
dti-1305	268	4	inactivation	inactivation	NOUN
dti-1305	268	5	was	be	AUX
dti-1305	268	6	dependent	dependent	ADJ
dti-1305	268	7	upon	upon	SCONJ
dti-1305	268	8	the	the	DET
dti-1305	268	9	oxidative	oxidative	ADJ
dti-1305	268	10	states	state	NOUN
dti-1305	268	11	of	of	ADP
dti-1305	268	12	tr	tr	VERB
dti-1305	268	13	,	,	PUNCT
dti-1305	268	14	with	with	ADP
dti-1305	268	15	nadph	nadph	ADV
dti-1305	268	16	-	-	PUNCT
dti-1305	268	17	reduced	reduce	VERB
dti-1305	268	18	tr	tr	NOUN
dti-1305	268	19	form	form	NOUN
dti-1305	268	20	being	be	AUX
dti-1305	268	21	inactivated	inactivate	VERB
dti-1305	268	22	faster	fast	ADV
dti-1305	268	23	.	.	PUNCT
dti-1305	269	1	the	the	DET
dti-1305	269	2	structure	structure	NOUN
dti-1305	269	3	of	of	ADP
dti-1305	269	4	tr	tr	VERB
dti-1305	269	5	-	-	PUNCT
dti-1305	269	6	quinacrine	quinacrine	ADJ
dti-1305	269	7	mustard	mustard	NOUN
dti-1305	269	8	-	-	PUNCT
dti-1305	269	9	adduct	adduct	NOUN
dti-1305	269	10	solved	solve	VERB
dti-1305	269	11	to	to	ADP
dti-1305	269	12	2.7å	2.7å	PROPN
dti-1305	269	13	revealed	reveal	VERB
dti-1305	269	14	that	that	SCONJ
dti-1305	269	15	two	two	NUM
dti-1305	269	16	molecules	molecule	NOUN
dti-1305	269	17	of	of	ADP
dti-1305	269	18	ligand	ligand	NOUN
dti-1305	269	19	are	be	AUX
dti-1305	269	20	bound	bind	VERB
dti-1305	269	21	in	in	ADP
dti-1305	269	22	the	the	DET
dti-1305	269	23	trypanothione	trypanothione	NOUN
dti-1305	269	24	binding	bind	VERB
dti-1305	269	25	site	site	NOUN
dti-1305	269	26	of	of	ADP
dti-1305	269	27	tr	tr	VERB
dti-1305	269	28	.	.	PUNCT
dti-1305	269	29	each	each	DET
dti-1305	269	30	acridine	acridine	PROPN
dti-1305	269	31	moiety	moiety	NOUN
dti-1305	269	32	interacts	interact	VERB
dti-1305	269	33	through	through	ADP
dti-1305	269	34	πstacking	πstacking	NOUN
dti-1305	269	35	,	,	PUNCT
dti-1305	269	36	while	while	SCONJ
dti-1305	269	37	only	only	ADV
dti-1305	269	38	one	one	NUM
dti-1305	269	39	of	of	ADP
dti-1305	269	40	the	the	DET
dti-1305	269	41	acridine	acridine	ADJ
dti-1305	269	42	groups	group	NOUN
dti-1305	269	43	interacts	interact	VERB
dti-1305	269	44	with	with	ADP
dti-1305	269	45	a	a	DET
dti-1305	269	46	trypanothione	trypanothione	NOUN
dti-1305	269	47	residue	residue	NOUN
dti-1305	269	48	in	in	ADP
dti-1305	269	49	a	a	DET
dti-1305	269	50	similar	similar	ADJ
dti-1305	269	51	fashion	fashion	NOUN
dti-1305	269	52	(	(	PUNCT
dti-1305	269	53	saravanamuthu	saravanamuthu	PROPN
dti-1305	269	54	et	et	PROPN
dti-1305	269	55	al	al	PROPN
dti-1305	269	56	.	.	PROPN
dti-1305	269	57	2004	2004	NUM
dti-1305	269	58	)	)	PUNCT
dti-1305	269	59	.	.	PUNCT
dti-1305	270	1	recently	recently	ADV
dti-1305	270	2	,	,	PUNCT
dti-1305	270	3	several	several	ADJ
dti-1305	270	4	mannic	mannic	ADJ
dti-1305	270	5	bases	basis	NOUN
dti-1305	270	6	(	(	PUNCT
dti-1305	270	7	e.g.	e.g.	ADV
dti-1305	270	8	30	30	NUM
dti-1305	270	9	)	)	PUNCT
dti-1305	270	10	were	be	AUX
dti-1305	270	11	shown	show	VERB
dti-1305	270	12	by	by	ADP
dti-1305	270	13	lee	lee	PROPN
dti-1305	270	14	et	et	PROPN
dti-1305	270	15	al	al	PROPN
dti-1305	270	16	.	.	PROPN
dti-1305	271	1	(	(	PUNCT
dti-1305	271	2	2005	2005	NUM
dti-1305	271	3	)	)	PUNCT
dti-1305	272	1	to	to	PART
dti-1305	272	2	be	be	AUX
dti-1305	272	3	irreversible	irreversible	ADJ
dti-1305	272	4	inhibitors	inhibitor	NOUN
dti-1305	272	5	of	of	ADP
dti-1305	272	6	tr	tr	VERB
dti-1305	272	7	.	.	NOUN
dti-1305	272	8	hplc	hplc	PROPN
dti-1305	272	9	,	,	PUNCT
dti-1305	272	10	nmr	nmr	NOUN
dti-1305	272	11	and	and	CCONJ
dti-1305	272	12	ms	ms	NOUN
dti-1305	272	13	analyses	analysis	NOUN
dti-1305	272	14	were	be	AUX
dti-1305	272	15	performed	perform	VERB
dti-1305	272	16	to	to	PART
dti-1305	272	17	delineate	delineate	VERB
dti-1305	272	18	their	their	PRON
dti-1305	272	19	mechanism	mechanism	NOUN
dti-1305	272	20	of	of	ADP
dti-1305	272	21	action	action	NOUN
dti-1305	272	22	and	and	CCONJ
dti-1305	272	23	found	find	VERB
dti-1305	272	24	that	that	SCONJ
dti-1305	272	25	divinyl	divinyl	ADJ
dti-1305	272	26	ketone	ketone	NOUN
dti-1305	272	27	are	be	AUX
dti-1305	272	28	the	the	DET
dti-1305	272	29	key	key	ADJ
dti-1305	272	30	intermediates	intermediate	NOUN
dti-1305	272	31	to	to	PART
dti-1305	272	32	irreversibly	irreversibly	ADV
dti-1305	272	33	inhibit	inhibit	VERB
dti-1305	272	34	tr	tr	VERB
dti-1305	272	35	.	.	PUNCT
dti-1305	272	36	esiand	esiand	PROPN
dti-1305	272	37	maldi	maldi	PROPN
dti-1305	272	38	-	-	PUNCT
dti-1305	272	39	tof	tof	PROPN
dti-1305	272	40	-	-	PUNCT
dti-1305	272	41	ms	ms	NOUN
dti-1305	272	42	of	of	ADP
dti-1305	272	43	tr	tr	VERB
dti-1305	272	44	,	,	PUNCT
dti-1305	272	45	modifi	modifi	NOUN
dti-1305	272	46	ed	ed	PROPN
dti-1305	272	47	by	by	ADP
dti-1305	272	48	mannic	mannic	ADJ
dti-1305	272	49	base	base	NOUN
dti-1305	272	50	or	or	CCONJ
dti-1305	272	51	corresponding	corresponding	ADJ
dti-1305	272	52	divinyl	divinyl	ADJ
dti-1305	272	53	ketone	ketone	NOUN
dti-1305	272	54	,	,	PUNCT
dti-1305	272	55	demonstrated	demonstrate	VERB
dti-1305	272	56	n	n	PRON
dti-1305	272	57	h	h	NOUN
dti-1305	272	58	n	n	ADP
dti-1305	272	59	h	h	NOUN
dti-1305	273	1	n	n	ADP
dti-1305	273	2	h	h	NOUN
dti-1305	274	1	n	n	PRON
dti-1305	274	2	h	h	NOUN
dti-1305	275	1	oh	oh	INTJ
dti-1305	275	2	ho	ho	INTJ
dti-1305	276	1	oh	oh	INTJ
dti-1305	277	1	oh	oh	INTJ
dti-1305	277	2	o	o	INTJ
dti-1305	277	3	o	o	NOUN
dti-1305	277	4	3	3	NUM
dti-1305	277	5	4	4	NUM
dti-1305	277	6	3	3	NUM
dti-1305	277	7	24	24	NUM
dti-1305	277	8	,	,	PUNCT
dti-1305	277	9	ki	ki	PROPN
dti-1305	277	10	=	=	PUNCT
dti-1305	277	11	1.8	1.8	NUM
dti-1305	277	12	m	m	NOUN
dti-1305	277	13	,	,	PUNCT
dti-1305	277	14	ki	ki	PROPN
dti-1305	277	15	'	'	PART
dti-1305	278	1	=	=	SYM
dti-1305	278	2	13	13	NUM
dti-1305	278	3	m	m	NOUN
dti-1305	278	4	(	(	PUNCT
dti-1305	278	5	ponasik	ponasik	NOUN
dti-1305	278	6	et	et	PROPN
dti-1305	278	7	al	al	PROPN
dti-1305	278	8	.	.	PROPN
dti-1305	278	9	1995	1995	NUM
dti-1305	278	10	)	)	PUNCT
dti-1305	279	1	o	o	NOUN
dti-1305	279	2	o	o	INTJ
dti-1305	279	3	nh	nh	PROPN
dti-1305	279	4	h	h	PROPN
dti-1305	279	5	n	n	PROPN
dti-1305	279	6	nhoo	nhoo	PROPN
dti-1305	279	7	25	25	NUM
dti-1305	279	8	,	,	PUNCT
dti-1305	279	9	ki	ki	PROPN
dti-1305	279	10	=	=	PUNCT
dti-1305	279	11	144	144	NUM
dti-1305	279	12	m	m	NOUN
dti-1305	279	13	,	,	PUNCT
dti-1305	279	14	kinac	kinac	NOUN
dti-1305	279	15	=	=	NOUN
dti-1305	279	16	0.116	0.116	NUM
dti-1305	279	17	min-1	min-1	NOUN
dti-1305	279	18	(	(	PUNCT
dti-1305	279	19	bond	bond	NOUN
dti-1305	279	20	et	et	PROPN
dti-1305	279	21	al	al	PROPN
dti-1305	279	22	.	.	PROPN
dti-1305	279	23	1999	1999	NUM
dti-1305	279	24	)	)	PUNCT
dti-1305	280	1	s	s	VERB
dti-1305	280	2	s	s	X
dti-1305	280	3	s	s	NOUN
dti-1305	280	4	o	o	NOUN
dti-1305	280	5	26	26	NUM
dti-1305	280	6	,	,	PUNCT
dti-1305	280	7	modify	modify	VERB
dti-1305	280	8	cys52	cys52	NOUN
dti-1305	280	9	(	(	PUNCT
dti-1305	280	10	gallwitz	gallwitz	PROPN
dti-1305	280	11	et	et	PROPN
dti-1305	280	12	al	al	PROPN
dti-1305	280	13	.	.	PROPN
dti-1305	280	14	19	19	NUM
dti-1305	280	15	99	99	NUM
dti-1305	280	16	)	)	PUNCT
dti-1305	280	17	figure	figure	NOUN
dti-1305	280	18	11	11	NUM
dti-1305	280	19	.	.	PUNCT
dti-1305	281	1	the	the	DET
dti-1305	281	2	natural	natural	ADJ
dti-1305	281	3	product	product	NOUN
dti-1305	281	4	inhibitors	inhibitor	NOUN
dti-1305	281	5	of	of	ADP
dti-1305	281	6	trypanothione	trypanothione	NOUN
dti-1305	281	7	reductase	reductase	NOUN
dti-1305	281	8	.	.	PUNCT
dti-1305	282	1	drug	drug	NOUN
dti-1305	282	2	target	target	NOUN
dti-1305	282	3	insights	insight	NOUN
dti-1305	282	4	2007	2007	NUM
dti-1305	282	5	:	:	PUNCT
dti-1305	282	6	2	2	NUM
dti-1305	282	7	141	141	NUM
dti-1305	282	8	target	target	NOUN
dti-1305	282	9	for	for	ADP
dti-1305	282	10	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	282	11	and	and	CCONJ
dti-1305	282	12	antileishmanial	antileishmanial	ADJ
dti-1305	282	13	drug	drug	NOUN
dti-1305	282	14	design	design	NOUN
dti-1305	282	15	specifi	specifi	PROPN
dti-1305	282	16	c	c	PROPN
dti-1305	282	17	alkylation	alkylation	NOUN
dti-1305	282	18	of	of	ADP
dti-1305	282	19	cys52	cys52	NOUN
dti-1305	282	20	in	in	ADP
dti-1305	282	21	a	a	DET
dti-1305	282	22	manner	manner	NOUN
dti-1305	282	23	as	as	SCONJ
dti-1305	282	24	shown	show	VERB
dti-1305	282	25	in	in	ADP
dti-1305	282	26	figure	figure	NOUN
dti-1305	282	27	13	13	NUM
dti-1305	282	28	(	(	PUNCT
dti-1305	282	29	lee	lee	PROPN
dti-1305	282	30	et	et	PROPN
dti-1305	282	31	al	al	PROPN
dti-1305	282	32	.	.	PROPN
dti-1305	282	33	2005	2005	NUM
dti-1305	282	34	)	)	PUNCT
dti-1305	282	35	.	.	PUNCT
dti-1305	283	1	sixteen	sixteen	NUM
dti-1305	283	2	novel	novel	ADJ
dti-1305	283	3	pd	pd	NOUN
dti-1305	283	4	-	-	PUNCT
dti-1305	283	5	complexes	complex	NOUN
dti-1305	283	6	of	of	ADP
dti-1305	283	7	the	the	DET
dti-1305	283	8	bioactive	bioactive	PROPN
dti-1305	283	9	nitrofuryl	nitrofuryl	PROPN
dti-1305	283	10	thiosemicarbazones	thiosemicarbazone	NOUN
dti-1305	283	11	were	be	AUX
dti-1305	283	12	synthesized	synthesize	VERB
dti-1305	283	13	and	and	CCONJ
dti-1305	283	14	tested	test	VERB
dti-1305	283	15	for	for	ADP
dti-1305	283	16	their	their	PRON
dti-1305	283	17	in	in	X
dti-1305	283	18	vitro	vitro	X
dti-1305	283	19	activity	activity	NOUN
dti-1305	283	20	(	(	PUNCT
dti-1305	283	21	otero	otero	PROPN
dti-1305	283	22	et	et	PROPN
dti-1305	283	23	al	al	PROPN
dti-1305	283	24	.	.	PROPN
dti-1305	283	25	2006	2006	NUM
dti-1305	283	26	)	)	PUNCT
dti-1305	283	27	.	.	PUNCT
dti-1305	284	1	most	most	ADJ
dti-1305	284	2	complexes	complex	NOUN
dti-1305	284	3	showed	show	VERB
dti-1305	284	4	higher	high	ADJ
dti-1305	284	5	in	in	ADP
dti-1305	284	6	vitro	vitro	X
dti-1305	284	7	trypanocidal	trypanocidal	ADJ
dti-1305	284	8	activity	activity	NOUN
dti-1305	284	9	against	against	ADP
dti-1305	284	10	t.	t.	PROPN
dti-1305	284	11	cruzi	cruzi	PROPN
dti-1305	284	12	than	than	ADP
dti-1305	284	13	the	the	DET
dti-1305	284	14	standard	standard	ADJ
dti-1305	284	15	drug	drug	NOUN
dti-1305	284	16	nifurtimox	nifurtimox	PROPN
dti-1305	284	17	.	.	PUNCT
dti-1305	285	1	overall	overall	ADV
dti-1305	285	2	,	,	PUNCT
dti-1305	285	3	the	the	DET
dti-1305	285	4	activities	activity	NOUN
dti-1305	285	5	of	of	ADP
dti-1305	285	6	pd	pd	NOUN
dti-1305	285	7	complexes	complex	NOUN
dti-1305	285	8	≥their	≥their	PRON
dti-1305	285	9	parent	parent	NOUN
dti-1305	285	10	compounds	compound	VERB
dti-1305	285	11	.	.	PUNCT
dti-1305	286	1	it	it	PRON
dti-1305	286	2	has	have	AUX
dti-1305	286	3	been	be	AUX
dti-1305	286	4	suggested	suggest	VERB
dti-1305	286	5	that	that	SCONJ
dti-1305	286	6	main	main	ADJ
dti-1305	286	7	trypanocidal	trypanocidal	ADJ
dti-1305	286	8	mechanism	mechanism	NOUN
dti-1305	286	9	was	be	AUX
dti-1305	286	10	the	the	DET
dti-1305	286	11	production	production	NOUN
dti-1305	286	12	of	of	ADP
dti-1305	286	13	oxidative	oxidative	ADJ
dti-1305	286	14	stress	stress	NOUN
dti-1305	286	15	as	as	ADP
dti-1305	286	16	a	a	DET
dti-1305	286	17	result	result	NOUN
dti-1305	286	18	of	of	ADP
dti-1305	286	19	their	their	PRON
dti-1305	286	20	bioreduction	bioreduction	NOUN
dti-1305	286	21	with	with	ADP
dti-1305	286	22	the	the	DET
dti-1305	286	23	reductive	reductive	ADJ
dti-1305	286	24	enzymes	enzyme	NOUN
dti-1305	286	25	,	,	PUNCT
dti-1305	286	26	although	although	SCONJ
dti-1305	286	27	strong	strong	ADJ
dti-1305	286	28	dna	dna	NOUN
dti-1305	286	29	-	-	PUNCT
dti-1305	286	30	adduct	adduct	NOUN
dti-1305	286	31	formation	formation	NOUN
dti-1305	286	32	was	be	AUX
dti-1305	286	33	also	also	ADV
dti-1305	286	34	evident	evident	ADJ
dti-1305	286	35	(	(	PUNCT
dti-1305	286	36	otero	otero	PROPN
dti-1305	286	37	et	et	PROPN
dti-1305	286	38	al	al	PROPN
dti-1305	286	39	.	.	PROPN
dti-1305	286	40	2006	2006	NUM
dti-1305	286	41	)	)	PUNCT
dti-1305	286	42	.	.	PUNCT
dti-1305	287	1	subversive	subversive	ADJ
dti-1305	287	2	substrates	substrate	NOUN
dti-1305	287	3	of	of	ADP
dti-1305	287	4	trypanothione	trypanothione	NOUN
dti-1305	287	5	reductase	reductase	NOUN
dti-1305	287	6	nifurtimox	nifurtimox	PROPN
dti-1305	287	7	(	(	PUNCT
dti-1305	287	8	6	6	NUM
dti-1305	287	9	)	)	PUNCT
dti-1305	287	10	and	and	CCONJ
dti-1305	287	11	related	related	ADJ
dti-1305	287	12	compounds	compound	NOUN
dti-1305	287	13	exert	exert	VERB
dti-1305	287	14	their	their	PRON
dti-1305	287	15	parasiticidal	parasiticidal	NOUN
dti-1305	287	16	activity	activity	NOUN
dti-1305	287	17	through	through	ADP
dti-1305	287	18	acting	act	VERB
dti-1305	287	19	as	as	ADP
dti-1305	287	20	futile	futile	ADJ
dti-1305	287	21	,	,	PUNCT
dti-1305	287	22	superoxide	superoxide	NOUN
dti-1305	287	23	ion	ion	NOUN
dti-1305	287	24	producing	produce	VERB
dti-1305	287	25	substrates	substrate	NOUN
dti-1305	287	26	of	of	ADP
dti-1305	287	27	tr	tr	ADJ
dti-1305	287	28	.	.	PUNCT
dti-1305	288	1	tr	tr	VERB
dti-1305	288	2	and	and	CCONJ
dti-1305	288	3	gr	gr	PRON
dti-1305	288	4	reduce	reduce	VERB
dti-1305	288	5	these	these	DET
dti-1305	288	6	futile	futile	ADJ
dti-1305	288	7	,	,	PUNCT
dti-1305	288	8	superoxide	superoxide	NOUN
dti-1305	288	9	ion	ion	NOUN
dti-1305	288	10	producing	produce	VERB
dti-1305	288	11	substrates	substrate	NOUN
dti-1305	288	12	in	in	ADP
dti-1305	288	13	a	a	DET
dti-1305	288	14	single	single	ADJ
dti-1305	288	15	electron	electron	NOUN
dti-1305	288	16	step	step	NOUN
dti-1305	288	17	(	(	PUNCT
dti-1305	288	18	nadph	nadph	ADJ
dti-1305	288	19	+	+	CCONJ
dti-1305	288	20	2rno2	2rno2	NUM
dti-1305	288	21	→	→	SYM
dti-1305	288	22	2rno2	2rno2	NUM
dti-1305	288	23	•‾	•‾	NOUN
dti-1305	288	24	+	+	NOUN
dti-1305	288	25	2h+	2h+	NUM
dti-1305	288	26	;	;	PUNCT
dti-1305	288	27	2rno2	2rno2	NUM
dti-1305	288	28	•‾	•‾	NOUN
dti-1305	288	29	+	+	CCONJ
dti-1305	288	30	o2	o2	PROPN
dti-1305	288	31	→	→	SYM
dti-1305	288	32	2rno2	2rno2	NUM
dti-1305	288	33	+	+	CCONJ
dti-1305	288	34	o2	o2	PROPN
dti-1305	288	35	•‾	•‾	NOUN
dti-1305	288	36	)	)	PUNCT
dti-1305	288	37	,	,	PUNCT
dti-1305	288	38	a	a	DET
dti-1305	288	39	process	process	NOUN
dti-1305	288	40	by	by	ADP
dti-1305	288	41	which	which	PRON
dti-1305	288	42	nadph	nadph	ADJ
dti-1305	288	43	and	and	CCONJ
dti-1305	288	44	o2	o2	PROPN
dti-1305	288	45	are	be	AUX
dti-1305	288	46	wasted	waste	VERB
dti-1305	288	47	and	and	CCONJ
dti-1305	288	48	t[sh]2	t[sh]2	NOUN
dti-1305	288	49	is	be	AUX
dti-1305	288	50	inhibited	inhibit	VERB
dti-1305	288	51	/	/	SYM
dti-1305	288	52	oxidized	oxidize	VERB
dti-1305	288	53	by	by	ADP
dti-1305	288	54	scores	score	NOUN
dti-1305	288	55	of	of	ADP
dti-1305	288	56	newly	newly	ADV
dti-1305	288	57	formed	form	VERB
dti-1305	288	58	superoxide	superoxide	NOUN
dti-1305	288	59	ions	ion	NOUN
dti-1305	288	60	causing	cause	VERB
dti-1305	288	61	a	a	DET
dti-1305	288	62	reduction	reduction	NOUN
dti-1305	288	63	in	in	ADP
dti-1305	288	64	thiol	thiol	PROPN
dti-1305	288	65	/	/	SYM
dti-1305	288	66	disulfi	disulfi	NOUN
dti-1305	288	67	de	de	X
dti-1305	288	68	titer	titer	NOUN
dti-1305	288	69	and	and	CCONJ
dti-1305	288	70	thus	thus	ADV
dti-1305	288	71	producing	produce	VERB
dti-1305	288	72	oxidative	oxidative	ADJ
dti-1305	288	73	stress	stress	NOUN
dti-1305	288	74	(	(	PUNCT
dti-1305	288	75	henderson	henderson	PROPN
dti-1305	288	76	et	et	PROPN
dti-1305	288	77	al	al	PROPN
dti-1305	288	78	.	.	PROPN
dti-1305	288	79	1988	1988	NUM
dti-1305	288	80	;	;	PUNCT
dti-1305	288	81	schirmer	schirmer	PROPN
dti-1305	288	82	et	et	PROPN
dti-1305	288	83	al	al	PROPN
dti-1305	288	84	.	.	PROPN
dti-1305	288	85	1995	1995	NUM
dti-1305	288	86	)	)	PUNCT
dti-1305	288	87	.	.	PUNCT
dti-1305	289	1	this	this	DET
dti-1305	289	2	group	group	NOUN
dti-1305	289	3	of	of	ADP
dti-1305	289	4	compounds	compound	NOUN
dti-1305	289	5	,	,	PUNCT
dti-1305	289	6	known	know	VERB
dti-1305	289	7	as	as	ADP
dti-1305	289	8	‘	'	PUNCT
dti-1305	289	9	subversive	subversive	ADJ
dti-1305	289	10	substrates	substrate	NOUN
dti-1305	289	11	’	'	PUNCT
dti-1305	289	12	or	or	CCONJ
dti-1305	289	13	‘	'	PUNCT
dti-1305	289	14	turncoat	turncoat	VERB
dti-1305	289	15	inhibitors	inhibitor	NOUN
dti-1305	289	16	’	'	PUNCT
dti-1305	289	17	,	,	PUNCT
dti-1305	289	18	are	be	AUX
dti-1305	289	19	best	well	ADV
dti-1305	289	20	represented	represent	VERB
dti-1305	289	21	by	by	ADP
dti-1305	289	22	nitrofurans	nitrofuran	NOUN
dti-1305	289	23	or	or	CCONJ
dti-1305	289	24	quinones	quinone	NOUN
dti-1305	289	25	,	,	PUNCT
dti-1305	289	26	chemically	chemically	ADV
dti-1305	289	27	modified	modify	VERB
dti-1305	289	28	to	to	PART
dti-1305	289	29	take	take	VERB
dti-1305	289	30	into	into	ADP
dti-1305	289	31	account	account	NOUN
dti-1305	289	32	the	the	DET
dti-1305	289	33	substrate	substrate	NOUN
dti-1305	289	34	specifi	specifi	PROPN
dti-1305	289	35	city	city	PROPN
dti-1305	289	36	for	for	ADP
dti-1305	289	37	tr	tr	VERB
dti-1305	289	38	over	over	ADP
dti-1305	289	39	gr	gr	PROPN
dti-1305	289	40	(	(	PUNCT
dti-1305	289	41	cenas	cenas	PROPN
dti-1305	289	42	et	et	PROPN
dti-1305	289	43	al	al	PROPN
dti-1305	289	44	.	.	PROPN
dti-1305	289	45	1994a	1994a	NUM
dti-1305	289	46	and	and	CCONJ
dti-1305	289	47	b	b	NOUN
dti-1305	289	48	)	)	PUNCT
dti-1305	289	49	.	.	PUNCT
dti-1305	290	1	thus	thus	ADV
dti-1305	290	2	,	,	PUNCT
dti-1305	290	3	chinifur	chinifur	NOUN
dti-1305	290	4	(	(	PUNCT
dti-1305	290	5	31	31	NUM
dti-1305	290	6	)	)	PUNCT
dti-1305	290	7	,	,	PUNCT
dti-1305	290	8	a	a	DET
dti-1305	290	9	nitrofuran	nitrofuran	NOUN
dti-1305	290	10	derivative	derivative	NOUN
dti-1305	290	11	with	with	ADP
dti-1305	290	12	a	a	DET
dti-1305	290	13	positively	positively	ADV
dti-1305	290	14	charged	charge	VERB
dti-1305	290	15	side	side	NOUN
dti-1305	290	16	chain	chain	NOUN
dti-1305	290	17	,	,	PUNCT
dti-1305	290	18	was	be	AUX
dti-1305	290	19	discovered	discover	VERB
dti-1305	290	20	as	as	ADP
dti-1305	290	21	a	a	DET
dti-1305	290	22	selective	selective	ADJ
dti-1305	290	23	inhibitor	inhibitor	NOUN
dti-1305	290	24	and	and	CCONJ
dti-1305	290	25	subversive	subversive	ADJ
dti-1305	290	26	substrate	substrate	NOUN
dti-1305	290	27	of	of	ADP
dti-1305	290	28	tr	tr	VERB
dti-1305	290	29	(	(	PUNCT
dti-1305	290	30	cenas	cenas	PROPN
dti-1305	290	31	et	et	PROPN
dti-1305	290	32	al	al	PROPN
dti-1305	290	33	.	.	PROPN
dti-1305	290	34	1994a	1994a	NUM
dti-1305	290	35	)	)	PUNCT
dti-1305	290	36	.	.	PUNCT
dti-1305	291	1	recently	recently	ADV
dti-1305	291	2	,	,	PUNCT
dti-1305	291	3	the	the	DET
dti-1305	291	4	anti	anti	ADJ
dti-1305	291	5	-	-	ADJ
dti-1305	291	6	tr	tr	ADJ
dti-1305	291	7	activities	activity	NOUN
dti-1305	291	8	of	of	ADP
dti-1305	291	9	a	a	DET
dti-1305	291	10	series	series	NOUN
dti-1305	291	11	of	of	ADP
dti-1305	291	12	nitrofuran	nitrofuran	PROPN
dti-1305	291	13	and	and	CCONJ
dti-1305	291	14	nitroimidazole	nitroimidazole	NOUN
dti-1305	291	15	derivatives	derivative	NOUN
dti-1305	291	16	were	be	AUX
dti-1305	291	17	studied	study	VERB
dti-1305	291	18	to	to	PART
dti-1305	291	19	examine	examine	VERB
dti-1305	291	20	the	the	DET
dti-1305	291	21	mechanism	mechanism	NOUN
dti-1305	291	22	of	of	ADP
dti-1305	291	23	action	action	NOUN
dti-1305	291	24	of	of	ADP
dti-1305	291	25	different	different	ADJ
dti-1305	291	26	types	type	NOUN
dti-1305	291	27	of	of	ADP
dti-1305	291	28	n	n	PROPN
dti-1305	291	29	nn	nn	X
dti-1305	291	30	pt2	pt2	PROPN
dti-1305	291	31	+	+	PROPN
dti-1305	291	32	n	n	CCONJ
dti-1305	291	33	br	br	PROPN
dti-1305	291	34	27	27	NUM
dti-1305	291	35	n	n	PROPN
dti-1305	291	36	nn	nn	PROPN
dti-1305	291	37	pt2	pt2	PROPN
dti-1305	291	38	+	+	PROPN
dti-1305	291	39	s	s	X
dti-1305	291	40	s	s	X
dti-1305	291	41	oh	oh	INTJ
dti-1305	291	42	h	h	NOUN
dti-1305	291	43	n	n	PRON
dti-1305	291	44	nh+	nh+	NOUN
dti-1305	291	45	2no3	2no3	NUM
dti-1305	291	46	meo	meo	PROPN
dti-1305	291	47	cl	cl	PROPN
dti-1305	291	48	28	28	NUM
dti-1305	291	49	hn	hn	PROPN
dti-1305	291	50	n	n	CCONJ
dti-1305	291	51	meo	meo	PROPN
dti-1305	291	52	cl	cl	PROPN
dti-1305	291	53	ch3	ch3	PROPN
dti-1305	291	54	n	n	CCONJ
dti-1305	291	55	cl	cl	NOUN
dti-1305	291	56	cl	cl	NOUN
dti-1305	291	57	29	29	NUM
dti-1305	291	58	figure	figure	NOUN
dti-1305	291	59	12	12	NUM
dti-1305	291	60	.	.	PUNCT
dti-1305	292	1	structures	structure	NOUN
dti-1305	292	2	of	of	ADP
dti-1305	292	3	irreversible	irreversible	ADJ
dti-1305	292	4	inhibitors	inhibitor	NOUN
dti-1305	292	5	of	of	ADP
dti-1305	292	6	trypanothione	trypanothione	NOUN
dti-1305	292	7	reductase	reductase	NOUN
dti-1305	292	8	.	.	PUNCT
dti-1305	293	1	o	o	NOUN
dti-1305	294	1	n	n	NUM
dti-1305	294	2	o	o	PROPN
dti-1305	294	3	cl	cl	NOUN
dti-1305	294	4	30	30	NUM
dti-1305	294	5	rsh	rsh	ADJ
dti-1305	294	6	,	,	PUNCT
dti-1305	294	7	-unsaturated	-unsaturated	ADJ
dti-1305	294	8	mannic	mannic	ADJ
dti-1305	294	9	base	base	NOUN
dti-1305	294	10	1st	1st	PROPN
dti-1305	294	11	michael	michael	PROPN
dti-1305	295	1	addition	addition	NOUN
dti-1305	295	2	o	o	NOUN
dti-1305	295	3	n	n	CCONJ
dti-1305	296	1	o	o	NOUN
dti-1305	296	2	cl	cl	NOUN
dti-1305	296	3	h	h	NOUN
dti-1305	296	4	sr	sr	PROPN
dti-1305	296	5	on+	on+	PROPN
dti-1305	296	6	o	o	PROPN
dti-1305	296	7	cl	cl	NOUN
dti-1305	297	1	sr	sr	PROPN
dti-1305	297	2	h	h	PROPN
dti-1305	297	3	ocl	ocl	PROPN
dti-1305	297	4	sr	sr	PROPN
dti-1305	298	1	hn	hn	PROPN
dti-1305	298	2	o	o	PROPN
dti-1305	298	3	ocl	ocl	PROPN
dti-1305	298	4	rshdivinyl	rshdivinyl	PROPN
dti-1305	298	5	ketone	ketone	NOUN
dti-1305	298	6	intermediate	intermediate	ADJ
dti-1305	298	7	rsh	rsh	PROPN
dti-1305	298	8	2nd	2nd	PROPN
dti-1305	298	9	michael	michael	PROPN
dti-1305	298	10	addition	addition	PROPN
dti-1305	298	11	ocl	ocl	PROPN
dti-1305	298	12	sr	sr	PROPN
dti-1305	298	13	figure	figure	NOUN
dti-1305	298	14	13	13	NUM
dti-1305	298	15	.	.	PUNCT
dti-1305	298	16	proposed	propose	VERB
dti-1305	298	17	reaction	reaction	NOUN
dti-1305	298	18	mechanisms	mechanism	NOUN
dti-1305	298	19	for	for	ADP
dti-1305	298	20	the	the	DET
dti-1305	298	21	modifi	modifi	NOUN
dti-1305	298	22	cation	cation	NOUN
dti-1305	298	23	of	of	ADP
dti-1305	298	24	protein	protein	NOUN
dti-1305	298	25	thiol	thiol	NOUN
dti-1305	298	26	(	(	PUNCT
dti-1305	298	27	rsh	rsh	PROPN
dti-1305	298	28	)	)	PUNCT
dti-1305	298	29	,	,	PUNCT
dti-1305	298	30	e.g.	e.g.	ADV
dti-1305	298	31	cys52	cys52	NOUN
dti-1305	298	32	in	in	ADP
dti-1305	298	33	t.	t.	PROPN
dti-1305	298	34	cruzi	cruzi	PROPN
dti-1305	298	35	trypanothione	trypanothione	PROPN
dti-1305	298	36	reductase	reductase	NOUN
dti-1305	298	37	by	by	ADP
dti-1305	298	38	an	an	DET
dti-1305	298	39	unsaturated	unsaturated	ADJ
dti-1305	298	40	mannic	mannic	ADJ
dti-1305	298	41	base	base	NOUN
dti-1305	298	42	such	such	ADJ
dti-1305	298	43	as	as	ADP
dti-1305	298	44	30	30	NUM
dti-1305	298	45	(	(	PUNCT
dti-1305	298	46	modifi	modifi	PROPN
dti-1305	298	47	ed	ed	PROPN
dti-1305	298	48	from	from	ADP
dti-1305	298	49	lee	lee	PROPN
dti-1305	298	50	et	et	PROPN
dti-1305	298	51	al	al	PROPN
dti-1305	298	52	.	.	PROPN
dti-1305	298	53	2005	2005	NUM
dti-1305	298	54	)	)	PUNCT
dti-1305	298	55	.	.	PUNCT
dti-1305	299	1	drug	drug	NOUN
dti-1305	299	2	target	target	NOUN
dti-1305	299	3	insights	insight	NOUN
dti-1305	299	4	2007	2007	NUM
dti-1305	299	5	:	:	PUNCT
dti-1305	299	6	2	2	NUM
dti-1305	299	7	142	142	NUM
dti-1305	299	8	khan	khan	PROPN
dti-1305	299	9	nitro	nitro	NOUN
dti-1305	299	10	-	-	PUNCT
dti-1305	299	11	group	group	NOUN
dti-1305	299	12	containing	contain	VERB
dti-1305	299	13	compounds	compound	NOUN
dti-1305	299	14	.	.	PUNCT
dti-1305	300	1	the	the	DET
dti-1305	300	2	results	result	NOUN
dti-1305	300	3	indicated	indicate	VERB
dti-1305	300	4	that	that	SCONJ
dti-1305	300	5	the	the	DET
dti-1305	300	6	nitrofurans	nitrofuran	NOUN
dti-1305	300	7	,	,	PUNCT
dti-1305	300	8	e.g.	e.g.	ADV
dti-1305	300	9	nifurtimox	nifurtimox	PROPN
dti-1305	300	10	act	act	NOUN
dti-1305	300	11	as	as	ADP
dti-1305	300	12	futile	futile	ADJ
dti-1305	300	13	-	-	PUNCT
dti-1305	300	14	cyclers	cycler	NOUN
dti-1305	300	15	as	as	SCONJ
dti-1305	300	16	discussed	discuss	VERB
dti-1305	300	17	above	above	ADV
dti-1305	300	18	,	,	PUNCT
dti-1305	300	19	whereas	whereas	SCONJ
dti-1305	300	20	5	5	NUM
dti-1305	300	21	-	-	PUNCT
dti-1305	300	22	nitroimidazoles	nitroimidazole	NOUN
dti-1305	300	23	,	,	PUNCT
dti-1305	300	24	e.g.	e.g.	ADV
dti-1305	300	25	megazole	megazole	NOUN
dti-1305	300	26	(	(	PUNCT
dti-1305	300	27	32	32	NUM
dti-1305	300	28	)	)	PUNCT
dti-1305	300	29	act	act	NOUN
dti-1305	300	30	as	as	ADP
dti-1305	300	31	thiol	thiol	ADJ
dti-1305	300	32	scavengers	scavenger	NOUN
dti-1305	300	33	particularly	particularly	ADV
dti-1305	300	34	for	for	ADP
dti-1305	300	35	t[sh]2	t[sh]2	NUM
dti-1305	300	36	thus	thus	ADV
dti-1305	300	37	reducing	reduce	VERB
dti-1305	300	38	the	the	DET
dti-1305	300	39	thiol	thiol	NOUN
dti-1305	300	40	/	/	SYM
dti-1305	300	41	disulfi	disulfi	NOUN
dti-1305	300	42	de	de	X
dti-1305	300	43	titer	titer	NOUN
dti-1305	300	44	which	which	PRON
dti-1305	300	45	is	be	AUX
dti-1305	300	46	detrimental	detrimental	ADJ
dti-1305	300	47	for	for	ADP
dti-1305	300	48	the	the	DET
dti-1305	300	49	parasites	parasite	NOUN
dti-1305	300	50	’	’	PART
dti-1305	300	51	survival	survival	NOUN
dti-1305	300	52	(	(	PUNCT
dti-1305	300	53	maya	maya	PROPN
dti-1305	300	54	et	et	PROPN
dti-1305	300	55	al	al	PROPN
dti-1305	300	56	.	.	PROPN
dti-1305	300	57	2003	2003	NUM
dti-1305	300	58	)	)	PUNCT
dti-1305	300	59	.	.	PUNCT
dti-1305	301	1	vega	vega	PROPN
dti-1305	301	2	-	-	PUNCT
dti-1305	301	3	teijido	teijido	VERB
dti-1305	301	4	et	et	NOUN
dti-1305	301	5	al	al	PROPN
dti-1305	301	6	(	(	PUNCT
dti-1305	301	7	2006	2006	NUM
dti-1305	301	8	)	)	PUNCT
dti-1305	301	9	explored	explore	VERB
dti-1305	301	10	three	three	NUM
dti-1305	301	11	possible	possible	ADJ
dti-1305	301	12	binding	bind	VERB
dti-1305	301	13	sites	site	NOUN
dti-1305	301	14	of	of	ADP
dti-1305	301	15	tr	tr	VERB
dti-1305	301	16	and	and	CCONJ
dti-1305	301	17	gr	gr	NOUN
dti-1305	301	18	,	,	PUNCT
dti-1305	301	19	i.e.	i.e.	X
dti-1305	301	20	the	the	DET
dti-1305	301	21	active	active	ADJ
dti-1305	301	22	site	site	NOUN
dti-1305	301	23	,	,	PUNCT
dti-1305	301	24	the	the	DET
dti-1305	301	25	dimer	dimer	NOUN
dti-1305	301	26	interface	interface	NOUN
dti-1305	301	27	and	and	CCONJ
dti-1305	301	28	the	the	DET
dti-1305	301	29	nadph	nadph	ADJ
dti-1305	301	30	binding	bind	VERB
dti-1305	301	31	site	site	NOUN
dti-1305	301	32	to	to	PART
dti-1305	301	33	study	study	VERB
dti-1305	301	34	the	the	DET
dti-1305	301	35	mechanism	mechanism	NOUN
dti-1305	301	36	of	of	ADP
dti-1305	301	37	action	action	NOUN
dti-1305	301	38	of	of	ADP
dti-1305	301	39	nitrofuran	nitrofuran	NOUN
dti-1305	301	40	and	and	CCONJ
dti-1305	301	41	nitrothiophene	nitrothiophene	PROPN
dti-1305	301	42	analogs	analog	NOUN
dti-1305	301	43	.	.	PUNCT
dti-1305	302	1	it	it	PRON
dti-1305	302	2	has	have	AUX
dti-1305	302	3	been	be	AUX
dti-1305	302	4	suggested	suggest	VERB
dti-1305	302	5	that	that	SCONJ
dti-1305	302	6	this	this	DET
dti-1305	302	7	class	class	NOUN
dti-1305	302	8	of	of	ADP
dti-1305	302	9	compounds	compound	NOUN
dti-1305	302	10	act	act	VERB
dti-1305	302	11	as	as	ADP
dti-1305	302	12	either	either	CCONJ
dti-1305	302	13	uncompetitive	uncompetitive	ADJ
dti-1305	302	14	or	or	CCONJ
dti-1305	302	15	mixed	mixed	ADJ
dti-1305	302	16	inhibitors	inhibitor	NOUN
dti-1305	302	17	of	of	ADP
dti-1305	302	18	tr	tr	VERB
dti-1305	302	19	.	.	PUNCT
dti-1305	303	1	moreover	moreover	ADV
dti-1305	303	2	,	,	PUNCT
dti-1305	303	3	it	it	PRON
dti-1305	303	4	has	have	AUX
dti-1305	303	5	also	also	ADV
dti-1305	303	6	been	be	AUX
dti-1305	303	7	indicated	indicate	VERB
dti-1305	303	8	that	that	SCONJ
dti-1305	303	9	the	the	DET
dti-1305	303	10	presence	presence	NOUN
dti-1305	303	11	of	of	ADP
dti-1305	303	12	an	an	DET
dti-1305	303	13	α	α	NOUN
dti-1305	303	14	-	-	PUNCT
dti-1305	303	15	helix	helix	NOUN
dti-1305	303	16	connecting	connect	VERB
dti-1305	303	17	the	the	DET
dti-1305	303	18	active	active	ADJ
dti-1305	303	19	site	site	NOUN
dti-1305	303	20	of	of	ADP
dti-1305	303	21	tr	tr	VERB
dti-1305	303	22	with	with	ADP
dti-1305	303	23	the	the	DET
dti-1305	303	24	interface	interface	NOUN
dti-1305	303	25	may	may	AUX
dti-1305	303	26	be	be	AUX
dti-1305	303	27	crucial	crucial	ADJ
dti-1305	303	28	for	for	ADP
dti-1305	303	29	charge	charge	NOUN
dti-1305	303	30	-	-	PUNCT
dti-1305	303	31	transfer	transfer	NOUN
dti-1305	303	32	processes	process	NOUN
dti-1305	303	33	.	.	PUNCT
dti-1305	304	1	1,4	1,4	NUM
dti-1305	304	2	-	-	PUNCT
dti-1305	304	3	naphthaqiuinone	naphthaqiuinone	ADJ
dti-1305	304	4	derivatives	derivative	NOUN
dti-1305	304	5	(	(	PUNCT
dti-1305	304	6	e.g.	e.g.	ADV
dti-1305	304	7	33	33	NUM
dti-1305	304	8	)	)	PUNCT
dti-1305	304	9	are	be	AUX
dti-1305	304	10	examples	example	NOUN
dti-1305	304	11	of	of	ADP
dti-1305	304	12	quinine	quinine	NOUN
dti-1305	304	13	-	-	PUNCT
dti-1305	304	14	based	base	VERB
dti-1305	304	15	subversive	subversive	ADJ
dti-1305	304	16	substrates	substrate	NOUN
dti-1305	304	17	of	of	ADP
dti-1305	304	18	tr	tr	VERB
dti-1305	304	19	,	,	PUNCT
dti-1305	304	20	designed	design	VERB
dti-1305	304	21	after	after	ADP
dti-1305	304	22	plumbagin	plumbagin	NOUN
dti-1305	304	23	.	.	PUNCT
dti-1305	305	1	compound	compound	NOUN
dti-1305	305	2	33	33	NUM
dti-1305	305	3	proved	prove	VERB
dti-1305	305	4	to	to	PART
dti-1305	305	5	be	be	AUX
dti-1305	305	6	a	a	DET
dti-1305	305	7	potent	potent	ADJ
dti-1305	305	8	subversive	subversive	ADJ
dti-1305	305	9	substrate	substrate	NOUN
dti-1305	305	10	and	and	CCONJ
dti-1305	305	11	an	an	DET
dti-1305	305	12	effective	effective	ADJ
dti-1305	305	13	uncompetitive	uncompetitive	ADJ
dti-1305	305	14	inhibitor	inhibitor	NOUN
dti-1305	305	15	of	of	ADP
dti-1305	305	16	tr	tr	VERB
dti-1305	305	17	versus	versus	ADP
dti-1305	305	18	t[sh]2	t[sh]2	PROPN
dti-1305	305	19	and	and	CCONJ
dti-1305	305	20	nadph	nadph	ADJ
dti-1305	305	21	(	(	PUNCT
dti-1305	305	22	salmon	salmon	NOUN
dti-1305	305	23	-	-	PUNCT
dti-1305	305	24	chemin	chemin	PROPN
dti-1305	305	25	et	et	PROPN
dti-1305	305	26	al	al	PROPN
dti-1305	305	27	.	.	PROPN
dti-1305	305	28	2001	2001	NUM
dti-1305	305	29	)	)	PUNCT
dti-1305	305	30	.	.	PUNCT
dti-1305	306	1	most	most	ADJ
dti-1305	306	2	of	of	ADP
dti-1305	306	3	these	these	DET
dti-1305	306	4	compounds	compound	NOUN
dti-1305	306	5	were	be	AUX
dti-1305	306	6	potent	potent	ADJ
dti-1305	306	7	inhibitors	inhibitor	NOUN
dti-1305	306	8	of	of	ADP
dti-1305	306	9	the	the	DET
dti-1305	306	10	parasites	parasite	NOUN
dti-1305	306	11	in	in	ADP
dti-1305	306	12	vitro	vitro	X
dti-1305	306	13	.	.	PUNCT
dti-1305	307	1	for	for	ADP
dti-1305	307	2	a	a	DET
dti-1305	307	3	series	series	NOUN
dti-1305	307	4	of	of	ADP
dti-1305	307	5	naphthaquinones	naphthaquinone	NOUN
dti-1305	307	6	,	,	PUNCT
dti-1305	307	7	a	a	DET
dti-1305	307	8	correlation	correlation	NOUN
dti-1305	307	9	between	between	ADP
dti-1305	307	10	their	their	PRON
dti-1305	307	11	potency	potency	NOUN
dti-1305	307	12	as	as	ADP
dti-1305	307	13	subversive	subversive	ADJ
dti-1305	307	14	substrates	substrate	NOUN
dti-1305	307	15	in	in	ADP
dti-1305	307	16	vitro	vitro	X
dti-1305	307	17	and	and	CCONJ
dti-1305	307	18	trypanocidal	trypanocidal	ADJ
dti-1305	307	19	activity	activity	NOUN
dti-1305	307	20	in	in	ADP
dti-1305	307	21	vivo	vivo	NOUN
dti-1305	307	22	has	have	AUX
dti-1305	307	23	been	be	AUX
dti-1305	307	24	demonstrated	demonstrate	VERB
dti-1305	307	25	(	(	PUNCT
dti-1305	307	26	salmon	salmon	NOUN
dti-1305	307	27	-	-	PUNCT
dti-1305	307	28	chemin	chemin	PROPN
dti-1305	307	29	et	et	PROPN
dti-1305	307	30	al	al	PROPN
dti-1305	307	31	.	.	PROPN
dti-1305	307	32	2001	2001	NUM
dti-1305	307	33	)	)	PUNCT
dti-1305	307	34	.	.	PUNCT
dti-1305	308	1	this	this	DET
dti-1305	308	2	‘	'	PUNCT
dti-1305	308	3	alternative	alternative	ADJ
dti-1305	308	4	approach	approach	NOUN
dti-1305	308	5	to	to	ADP
dti-1305	308	6	chemotherapy	chemotherapy	NOUN
dti-1305	308	7	of	of	ADP
dti-1305	308	8	chagas	chagas	PROPN
dti-1305	308	9	disease	disease	NOUN
dti-1305	308	10	’	'	PUNCT
dti-1305	308	11	has	have	AUX
dti-1305	308	12	been	be	AUX
dti-1305	308	13	considered	consider	VERB
dti-1305	308	14	one	one	NUM
dti-1305	308	15	of	of	ADP
dti-1305	308	16	the	the	DET
dti-1305	308	17	most	most	ADV
dti-1305	308	18	promising	promising	ADJ
dti-1305	308	19	advances	advance	NOUN
dti-1305	308	20	.	.	PUNCT
dti-1305	309	1	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	309	2	prospects	prospect	NOUN
dti-1305	309	3	of	of	ADP
dti-1305	309	4	the	the	DET
dti-1305	309	5	trypanothione	trypanothione	ADJ
dti-1305	309	6	reductase	reductase	NOUN
dti-1305	309	7	inhibitors	inhibitor	NOUN
dti-1305	309	8	for	for	ADP
dti-1305	309	9	an	an	DET
dti-1305	309	10	enzyme	enzyme	NOUN
dti-1305	309	11	inhibitor	inhibitor	NOUN
dti-1305	309	12	to	to	PART
dti-1305	309	13	become	become	VERB
dti-1305	309	14	a	a	DET
dti-1305	309	15	practical	practical	ADJ
dti-1305	309	16	drug	drug	NOUN
dti-1305	309	17	,	,	PUNCT
dti-1305	309	18	several	several	ADJ
dti-1305	309	19	criteria	criterion	NOUN
dti-1305	309	20	must	must	AUX
dti-1305	309	21	be	be	AUX
dti-1305	309	22	met	meet	VERB
dti-1305	309	23	:	:	PUNCT
dti-1305	309	24	(	(	PUNCT
dti-1305	309	25	i	i	NOUN
dti-1305	309	26	)	)	PUNCT
dti-1305	309	27	the	the	DET
dti-1305	309	28	biochemical	biochemical	ADJ
dti-1305	309	29	pathway	pathway	NOUN
dti-1305	309	30	that	that	PRON
dti-1305	309	31	is	be	AUX
dti-1305	309	32	inhibited	inhibit	VERB
dti-1305	309	33	must	must	AUX
dti-1305	309	34	be	be	AUX
dti-1305	309	35	related	relate	VERB
dti-1305	309	36	to	to	ADP
dti-1305	309	37	the	the	DET
dti-1305	309	38	disease	disease	NOUN
dti-1305	309	39	state	state	NOUN
dti-1305	309	40	in	in	ADP
dti-1305	309	41	such	such	DET
dti-1305	309	42	a	a	DET
dti-1305	309	43	way	way	NOUN
dti-1305	309	44	that	that	PRON
dti-1305	309	45	inhibition	inhibition	NOUN
dti-1305	309	46	of	of	ADP
dti-1305	309	47	that	that	DET
dti-1305	309	48	pathway	pathway	NOUN
dti-1305	309	49	in	in	ADP
dti-1305	309	50	a	a	DET
dti-1305	309	51	patient	patient	NOUN
dti-1305	309	52	is	be	AUX
dti-1305	309	53	therapeutic	therapeutic	ADJ
dti-1305	309	54	;	;	PUNCT
dti-1305	309	55	(	(	PUNCT
dti-1305	309	56	ii	ii	NOUN
dti-1305	309	57	)	)	PUNCT
dti-1305	309	58	the	the	DET
dti-1305	309	59	enzyme	enzyme	NOUN
dti-1305	309	60	inhibitor	inhibitor	NOUN
dti-1305	309	61	must	must	AUX
dti-1305	309	62	be	be	AUX
dti-1305	309	63	specifi	specifi	PROPN
dti-1305	309	64	c	c	PROPN
dti-1305	310	1	so	so	SCONJ
dti-1305	310	2	that	that	SCONJ
dti-1305	310	3	unwanted	unwanted	ADJ
dti-1305	310	4	inhibition	inhibition	NOUN
dti-1305	310	5	of	of	ADP
dti-1305	310	6	other	other	ADJ
dti-1305	310	7	pathways	pathway	NOUN
dti-1305	310	8	or	or	CCONJ
dti-1305	310	9	receptors	receptor	NOUN
dti-1305	310	10	does	do	AUX
dti-1305	310	11	not	not	PART
dti-1305	310	12	occur	occur	VERB
dti-1305	310	13	at	at	ADP
dti-1305	310	14	therapeutic	therapeutic	ADJ
dti-1305	310	15	doses	dose	NOUN
dti-1305	310	16	;	;	PUNCT
dti-1305	310	17	(	(	PUNCT
dti-1305	310	18	iii	iii	X
dti-1305	310	19	)	)	PUNCT
dti-1305	310	20	the	the	DET
dti-1305	310	21	compounds	compound	NOUN
dti-1305	310	22	must	must	AUX
dti-1305	310	23	have	have	VERB
dti-1305	310	24	the	the	DET
dti-1305	310	25	pharmacokinetic	pharmacokinetic	ADJ
dti-1305	310	26	characteristics	characteristic	NOUN
dti-1305	310	27	of	of	ADP
dti-1305	310	28	a	a	DET
dti-1305	310	29	practical	practical	ADJ
dti-1305	310	30	drug	drug	NOUN
dti-1305	310	31	,	,	PUNCT
dti-1305	310	32	i.e.	i.e.	X
dti-1305	310	33	must	must	AUX
dti-1305	310	34	be	be	AUX
dti-1305	310	35	absorbed	absorb	VERB
dti-1305	310	36	,	,	PUNCT
dti-1305	310	37	must	must	AUX
dti-1305	310	38	penetrate	penetrate	VERB
dti-1305	310	39	to	to	ADP
dti-1305	310	40	the	the	DET
dti-1305	310	41	site	site	NOUN
dti-1305	310	42	of	of	ADP
dti-1305	310	43	action	action	NOUN
dti-1305	310	44	and	and	CCONJ
dti-1305	310	45	must	must	AUX
dti-1305	310	46	have	have	VERB
dti-1305	310	47	a	a	DET
dti-1305	310	48	reasonably	reasonably	ADV
dti-1305	310	49	predictable	predictable	ADJ
dti-1305	310	50	doseresponse	doseresponse	NOUN
dti-1305	310	51	relationship	relationship	NOUN
dti-1305	310	52	and	and	CCONJ
dti-1305	310	53	duration	duration	NOUN
dti-1305	310	54	of	of	ADP
dti-1305	310	55	action	action	NOUN
dti-1305	310	56	;	;	PUNCT
dti-1305	310	57	(	(	PUNCT
dti-1305	310	58	iv	iv	X
dti-1305	310	59	)	)	PUNCT
dti-1305	310	60	the	the	DET
dti-1305	310	61	compound	compound	NOUN
dti-1305	310	62	must	must	AUX
dti-1305	310	63	have	have	VERB
dti-1305	310	64	an	an	DET
dti-1305	310	65	acceptable	acceptable	ADJ
dti-1305	310	66	toxicological	toxicological	ADJ
dti-1305	310	67	profi	profi	NOUN
dti-1305	310	68	le	le	X
dti-1305	310	69	in	in	ADP
dti-1305	310	70	animals	animal	NOUN
dti-1305	310	71	,	,	PUNCT
dti-1305	310	72	and	and	CCONJ
dti-1305	310	73	the	the	DET
dti-1305	310	74	results	result	NOUN
dti-1305	310	75	of	of	ADP
dti-1305	310	76	clinical	clinical	ADJ
dti-1305	310	77	studies	study	NOUN
dti-1305	310	78	in	in	ADP
dti-1305	310	79	humans	human	NOUN
dti-1305	310	80	must	must	AUX
dti-1305	310	81	demonstrate	demonstrate	VERB
dti-1305	310	82	an	an	DET
dti-1305	310	83	appropriate	appropriate	ADJ
dti-1305	310	84	balance	balance	NOUN
dti-1305	310	85	between	between	ADP
dti-1305	310	86	benefi	benefi	PROPN
dti-1305	310	87	ts	ts	ADP
dti-1305	310	88	and	and	CCONJ
dti-1305	310	89	risks	risk	NOUN
dti-1305	310	90	in	in	ADP
dti-1305	310	91	therapeutic	therapeutic	ADJ
dti-1305	310	92	use	use	NOUN
dti-1305	310	93	;	;	PUNCT
dti-1305	310	94	(	(	PUNCT
dti-1305	310	95	v	v	X
dti-1305	310	96	)	)	PUNCT
dti-1305	310	97	the	the	DET
dti-1305	310	98	compound	compound	NOUN
dti-1305	310	99	must	must	AUX
dti-1305	310	100	survive	survive	VERB
dti-1305	310	101	a	a	DET
dti-1305	310	102	long	long	ADJ
dti-1305	310	103	and	and	CCONJ
dti-1305	310	104	expensive	expensive	ADJ
dti-1305	310	105	clinical	clinical	ADJ
dti-1305	310	106	development	development	NOUN
dti-1305	310	107	process	process	NOUN
dti-1305	310	108	and	and	CCONJ
dti-1305	310	109	ultimately	ultimately	ADV
dti-1305	310	110	be	be	AUX
dti-1305	310	111	approved	approve	VERB
dti-1305	310	112	by	by	ADP
dti-1305	310	113	regulatory	regulatory	ADJ
dti-1305	310	114	agencies	agency	NOUN
dti-1305	310	115	;	;	PUNCT
dti-1305	310	116	(	(	PUNCT
dti-1305	310	117	vi	vi	X
dti-1305	310	118	)	)	PUNCT
dti-1305	310	119	the	the	DET
dti-1305	310	120	compound	compound	NOUN
dti-1305	310	121	must	must	AUX
dti-1305	310	122	be	be	AUX
dti-1305	310	123	economically	economically	ADV
dti-1305	310	124	viable	viable	ADJ
dti-1305	310	125	in	in	ADP
dti-1305	310	126	the	the	DET
dti-1305	310	127	marketplace	marketplace	NOUN
dti-1305	310	128	and	and	CCONJ
dti-1305	310	129	compete	compete	VERB
dti-1305	310	130	successfully	successfully	ADV
dti-1305	310	131	with	with	ADP
dti-1305	310	132	other	other	ADJ
dti-1305	310	133	therapeutic	therapeutic	ADJ
dti-1305	310	134	alternatives	alternative	NOUN
dti-1305	310	135	(	(	PUNCT
dti-1305	310	136	crout	crout	NOUN
dti-1305	310	137	,	,	PUNCT
dti-1305	310	138	1989	1989	NUM
dti-1305	310	139	)	)	PUNCT
dti-1305	310	140	.	.	PUNCT
dti-1305	311	1	the	the	DET
dti-1305	311	2	criteria	criterion	NOUN
dti-1305	311	3	(	(	PUNCT
dti-1305	311	4	i	i	NOUN
dti-1305	311	5	)	)	PUNCT
dti-1305	311	6	and	and	CCONJ
dti-1305	311	7	(	(	PUNCT
dti-1305	311	8	ii	ii	NOUN
dti-1305	311	9	)	)	PUNCT
dti-1305	311	10	have	have	AUX
dti-1305	311	11	already	already	ADV
dti-1305	311	12	been	be	AUX
dti-1305	311	13	addressed	address	VERB
dti-1305	311	14	while	while	SCONJ
dti-1305	311	15	selecting	select	VERB
dti-1305	311	16	the	the	DET
dti-1305	311	17	target	target	NOUN
dti-1305	311	18	,	,	PUNCT
dti-1305	311	19	and	and	CCONJ
dti-1305	311	20	thus	thus	ADV
dti-1305	311	21	,	,	PUNCT
dti-1305	311	22	all	all	PRON
dti-1305	311	23	of	of	ADP
dti-1305	311	24	the	the	DET
dti-1305	311	25	above	above	ADJ
dti-1305	311	26	mentioned	mention	VERB
dti-1305	311	27	inhibitors	inhibitor	NOUN
dti-1305	311	28	have	have	AUX
dti-1305	311	29	fulfi	fulfi	NOUN
dti-1305	311	30	lled	lle	VERB
dti-1305	311	31	them	they	PRON
dti-1305	311	32	.	.	PUNCT
dti-1305	312	1	pharmacological	pharmacological	ADJ
dti-1305	312	2	and	and	CCONJ
dti-1305	312	3	toxicological	toxicological	ADJ
dti-1305	312	4	studies	study	NOUN
dti-1305	312	5	in	in	ADP
dti-1305	312	6	animal	animal	NOUN
dti-1305	312	7	models	model	NOUN
dti-1305	312	8	are	be	AUX
dti-1305	312	9	needed	need	VERB
dti-1305	312	10	to	to	PART
dti-1305	312	11	meet	meet	VERB
dti-1305	312	12	other	other	ADJ
dti-1305	312	13	criteria	criterion	NOUN
dti-1305	312	14	.	.	PUNCT
dti-1305	313	1	although	although	SCONJ
dti-1305	313	2	many	many	ADJ
dti-1305	313	3	potent	potent	ADJ
dti-1305	313	4	inhibitors	inhibitor	NOUN
dti-1305	313	5	of	of	ADP
dti-1305	313	6	tr	tr	VERB
dti-1305	313	7	have	have	AUX
dti-1305	313	8	been	be	AUX
dti-1305	313	9	discovered	discover	VERB
dti-1305	313	10	through	through	ADP
dti-1305	313	11	enzyme	enzyme	NOUN
dti-1305	313	12	screening	screening	NOUN
dti-1305	313	13	,	,	PUNCT
dti-1305	313	14	in	in	ADP
dti-1305	313	15	vivo	vivo	ADJ
dti-1305	313	16	evaluation	evaluation	NOUN
dti-1305	313	17	of	of	ADP
dti-1305	313	18	these	these	DET
dti-1305	313	19	lead	lead	NOUN
dti-1305	313	20	compounds	compound	NOUN
dti-1305	313	21	are	be	AUX
dti-1305	313	22	scant	scant	ADJ
dti-1305	313	23	.	.	PUNCT
dti-1305	314	1	several	several	ADJ
dti-1305	314	2	polyamine	polyamine	NOUN
dti-1305	314	3	derivatives	derivative	NOUN
dti-1305	314	4	that	that	PRON
dti-1305	314	5	were	be	AUX
dti-1305	314	6	shown	show	VERB
dti-1305	314	7	to	to	PART
dti-1305	314	8	be	be	AUX
dti-1305	314	9	potent	potent	ADJ
dti-1305	314	10	trypanocidals	trypanocidal	NOUN
dti-1305	314	11	in	in	ADP
dti-1305	314	12	vitro	vitro	X
dti-1305	314	13	(	(	PUNCT
dti-1305	314	14	with	with	ADP
dti-1305	314	15	ed50	ed50	PROPN
dti-1305	314	16	values	value	NOUN
dti-1305	314	17	in	in	ADP
dti-1305	314	18	submicromolar	submicromolar	ADJ
dti-1305	314	19	ranges	range	NOUN
dti-1305	314	20	)	)	PUNCT
dti-1305	314	21	failed	fail	VERB
dti-1305	314	22	to	to	PART
dti-1305	314	23	prolong	prolong	VERB
dti-1305	314	24	the	the	DET
dti-1305	314	25	lives	life	NOUN
dti-1305	314	26	of	of	ADP
dti-1305	314	27	experimental	experimental	ADJ
dti-1305	314	28	mice	mouse	NOUN
dti-1305	314	29	infected	infect	VERB
dti-1305	314	30	with	with	ADP
dti-1305	314	31	trypanosomes	trypanosome	NOUN
dti-1305	314	32	or	or	CCONJ
dti-1305	314	33	to	to	PART
dti-1305	314	34	cause	cause	VERB
dti-1305	314	35	a	a	DET
dti-1305	314	36	signifi	signifi	NOUN
dti-1305	314	37	ca	can	AUX
dti-1305	314	38	nt	not	PART
dti-1305	314	39	decrease	decrease	VERB
dti-1305	314	40	in	in	ADP
dti-1305	314	41	bloodstream	bloodstream	NOUN
dti-1305	314	42	parasitemia	parasitemia	NOUN
dti-1305	314	43	of	of	ADP
dti-1305	314	44	infected	infected	ADJ
dti-1305	314	45	mice	mouse	NOUN
dti-1305	314	46	(	(	PUNCT
dti-1305	314	47	o’sullivan	o’sullivan	NOUN
dti-1305	314	48	et	et	NOUN
dti-1305	314	49	al	al	PROPN
dti-1305	314	50	.	.	PROPN
dti-1305	314	51	1997	1997	NUM
dti-1305	314	52	)	)	PUNCT
dti-1305	314	53	.	.	PUNCT
dti-1305	315	1	however	however	ADV
dti-1305	315	2	,	,	PUNCT
dti-1305	315	3	none	none	NOUN
dti-1305	315	4	of	of	ADP
dti-1305	315	5	the	the	DET
dti-1305	315	6	compounds	compound	NOUN
dti-1305	315	7	exerted	exert	VERB
dti-1305	315	8	overt	overt	ADJ
dti-1305	315	9	toxicity	toxicity	NOUN
dti-1305	315	10	in	in	ADP
dti-1305	315	11	mice	mouse	NOUN
dti-1305	315	12	.	.	PUNCT
dti-1305	316	1	it	it	PRON
dti-1305	316	2	has	have	AUX
dti-1305	316	3	been	be	AUX
dti-1305	316	4	suggested	suggest	VERB
dti-1305	316	5	that	that	SCONJ
dti-1305	316	6	the	the	DET
dti-1305	316	7	lack	lack	NOUN
dti-1305	316	8	of	of	ADP
dti-1305	316	9	in	in	ADP
dti-1305	316	10	vivo	vivo	NOUN
dti-1305	316	11	trypanocidal	trypanocidal	ADJ
dti-1305	316	12	activity	activity	NOUN
dti-1305	316	13	may	may	AUX
dti-1305	316	14	be	be	AUX
dti-1305	316	15	due	due	ADJ
dti-1305	316	16	to	to	ADP
dti-1305	316	17	their	their	PRON
dti-1305	316	18	rapid	rapid	ADJ
dti-1305	316	19	elimination	elimination	NOUN
dti-1305	316	20	and/or	and/or	CCONJ
dti-1305	316	21	metabolism	metabolism	NOUN
dti-1305	316	22	.	.	PUNCT
dti-1305	317	1	since	since	SCONJ
dti-1305	317	2	these	these	DET
dti-1305	317	3	compounds	compound	NOUN
dti-1305	317	4	are	be	AUX
dti-1305	317	5	reversible	reversible	ADJ
dti-1305	317	6	inhibitors	inhibitor	NOUN
dti-1305	317	7	of	of	ADP
dti-1305	317	8	tr	tr	VERB
dti-1305	317	9	,	,	PUNCT
dti-1305	317	10	concentrations	concentration	NOUN
dti-1305	317	11	of	of	ADP
dti-1305	317	12	oo2n	oo2n	PROPN
dti-1305	317	13	n	n	CCONJ
dti-1305	317	14	nh	nh	NOUN
dti-1305	317	15	n	n	ADV
dti-1305	317	16	c2h5	c2h5	PROPN
dti-1305	317	17	c2h5o	c2h5o	PUNCT
dti-1305	317	18	h3c	h3c	X
dti-1305	317	19	31	31	NUM
dti-1305	317	20	,	,	PUNCT
dti-1305	317	21	ki	ki	PROPN
dti-1305	317	22	=	=	PUNCT
dti-1305	317	23	4.5	4.5	NUM
dti-1305	317	24	m	m	PROPN
dti-1305	317	25	(	(	PUNCT
dti-1305	317	26	cenas	cenas	PROPN
dti-1305	317	27	et	et	PROPN
dti-1305	317	28	al	al	PROPN
dti-1305	317	29	.	.	PROPN
dti-1305	317	30	1994a	1994a	NUM
dti-1305	317	31	)	)	PUNCT
dti-1305	318	1	n	n	CCONJ
dti-1305	318	2	no2n	no2n	PROPN
dti-1305	318	3	ch3	ch3	PROPN
dti-1305	318	4	n	n	CCONJ
dti-1305	318	5	n	n	NOUN
dti-1305	318	6	s	s	PART
dti-1305	318	7	nh2	nh2	NOUN
dti-1305	318	8	32	32	NUM
dti-1305	318	9	,	,	PUNCT
dti-1305	318	10	thiol	thiol	NOUN
dti-1305	318	11	scavenger	scavenger	NOUN
dti-1305	318	12	(	(	PUNCT
dti-1305	318	13	maya	maya	PROPN
dti-1305	318	14	et	et	PROPN
dti-1305	318	15	al	al	PROPN
dti-1305	318	16	.	.	PROPN
dti-1305	318	17	2003	2003	NUM
dti-1305	318	18	)	)	PUNCT
dti-1305	319	1	o	o	NOUN
dti-1305	319	2	o	o	X
dti-1305	319	3	ch3	ch3	PROPN
dti-1305	319	4	n	n	ADP
dti-1305	319	5	h	h	NOUN
dti-1305	320	1	n	n	VERB
dti-1305	320	2	h	h	NOUN
dti-1305	321	1	n	n	ADV
dti-1305	321	2	h	h	NOUN
dti-1305	322	1	o	o	NOUN
dti-1305	322	2	o	o	X
dti-1305	322	3	h3c	h3c	X
dti-1305	323	1	o	o	X
dti-1305	323	2	o	o	NOUN
dti-1305	323	3	4	4	NUM
dti-1305	323	4	4oh	4oh	NOUN
dti-1305	324	1	oh	oh	NUM
dti-1305	324	2	33	33	NUM
dti-1305	325	1	,	,	PUNCT
dti-1305	325	2	i50	i50	NOUN
dti-1305	325	3	=	=	NUM
dti-1305	325	4	0.45	0.45	NUM
dti-1305	325	5	m	m	NOUN
dti-1305	325	6	,	,	PUNCT
dti-1305	325	7	km	km	PROPN
dti-1305	325	8	28	28	NUM
dti-1305	325	9	m	m	NOUN
dti-1305	325	10	,	,	PUNCT
dti-1305	325	11	(	(	PUNCT
dti-1305	325	12	salmon	salmon	NOUN
dti-1305	325	13	-	-	PUNCT
dti-1305	325	14	chemin	chemin	PROPN
dti-1305	325	15	et	et	PROPN
dti-1305	325	16	al	al	PROPN
dti-1305	325	17	.	.	PROPN
dti-1305	325	18	1994a	1994a	NUM
dti-1305	325	19	)	)	PUNCT
dti-1305	325	20	figure	figure	NOUN
dti-1305	325	21	14	14	NUM
dti-1305	325	22	.	.	PUNCT
dti-1305	326	1	structures	structure	NOUN
dti-1305	326	2	and	and	CCONJ
dti-1305	326	3	activity	activity	NOUN
dti-1305	326	4	of	of	ADP
dti-1305	326	5	subversive	subversive	ADJ
dti-1305	326	6	substrates	substrate	NOUN
dti-1305	326	7	of	of	ADP
dti-1305	326	8	trypanothione	trypanothione	NOUN
dti-1305	326	9	reductase	reductase	NOUN
dti-1305	326	10	.	.	PUNCT
dti-1305	327	1	drug	drug	NOUN
dti-1305	327	2	target	target	NOUN
dti-1305	327	3	insights	insight	NOUN
dti-1305	327	4	2007	2007	NUM
dti-1305	327	5	:	:	PUNCT
dti-1305	327	6	2	2	NUM
dti-1305	327	7	143	143	NUM
dti-1305	327	8	target	target	NOUN
dti-1305	327	9	for	for	ADP
dti-1305	327	10	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	327	11	and	and	CCONJ
dti-1305	327	12	antileishmanial	antileishmanial	ADJ
dti-1305	327	13	drug	drug	NOUN
dti-1305	327	14	design	design	NOUN
dti-1305	327	15	these	these	DET
dti-1305	327	16	compounds	compound	NOUN
dti-1305	327	17	may	may	AUX
dti-1305	327	18	not	not	PART
dti-1305	327	19	be	be	AUX
dti-1305	327	20	maintained	maintain	VERB
dti-1305	327	21	,	,	PUNCT
dti-1305	327	22	and	and	CCONJ
dti-1305	327	23	as	as	ADP
dti-1305	327	24	a	a	DET
dti-1305	327	25	result	result	NOUN
dti-1305	327	26	,	,	PUNCT
dti-1305	327	27	tr	tr	NOUN
dti-1305	327	28	activity	activity	NOUN
dti-1305	327	29	will	will	AUX
dti-1305	327	30	not	not	PART
dti-1305	327	31	be	be	AUX
dti-1305	327	32	signifi	signifi	NOUN
dti-1305	327	33	cantly	cantly	ADV
dti-1305	327	34	decreased	decrease	VERB
dti-1305	327	35	(	(	PUNCT
dti-1305	327	36	o’sullivan	o’sullivan	NOUN
dti-1305	327	37	et	et	NOUN
dti-1305	327	38	al	al	PROPN
dti-1305	327	39	.	.	PROPN
dti-1305	327	40	1997	1997	NUM
dti-1305	327	41	)	)	PUNCT
dti-1305	327	42	.	.	PUNCT
dti-1305	328	1	it	it	PRON
dti-1305	328	2	has	have	AUX
dti-1305	328	3	also	also	ADV
dti-1305	328	4	been	be	AUX
dti-1305	328	5	suggested	suggest	VERB
dti-1305	328	6	that	that	SCONJ
dti-1305	328	7	converting	convert	VERB
dti-1305	328	8	reversible	reversible	ADJ
dti-1305	328	9	inhibitors	inhibitor	NOUN
dti-1305	328	10	into	into	ADP
dti-1305	328	11	irreversible	irreversible	ADJ
dti-1305	328	12	inhibitors	inhibitor	NOUN
dti-1305	328	13	through	through	ADP
dti-1305	328	14	complexation	complexation	NOUN
dti-1305	328	15	with	with	ADP
dti-1305	328	16	metal	metal	NOUN
dti-1305	328	17	ions	ion	NOUN
dti-1305	328	18	might	might	AUX
dti-1305	328	19	be	be	AUX
dti-1305	328	20	a	a	DET
dti-1305	328	21	reasonable	reasonable	ADJ
dti-1305	328	22	strategy	strategy	NOUN
dti-1305	328	23	for	for	ADP
dti-1305	328	24	identifying	identify	VERB
dti-1305	328	25	improved	improve	VERB
dti-1305	328	26	leads	lead	NOUN
dti-1305	328	27	with	with	ADP
dti-1305	328	28	enhanced	enhance	VERB
dti-1305	328	29	in	in	ADP
dti-1305	328	30	vivo	vivo	ADJ
dti-1305	328	31	profi	profi	PROPN
dti-1305	328	32	les	les	PROPN
dti-1305	328	33	.	.	PUNCT
dti-1305	329	1	clomipramine	clomipramine	NOUN
dti-1305	329	2	and	and	CCONJ
dti-1305	329	3	thioridazine	thioridazine	PROPN
dti-1305	329	4	were	be	AUX
dti-1305	329	5	shown	show	VERB
dti-1305	329	6	to	to	PART
dti-1305	329	7	be	be	AUX
dti-1305	329	8	effective	effective	ADJ
dti-1305	329	9	in	in	ADP
dti-1305	329	10	treatment	treatment	NOUN
dti-1305	329	11	of	of	ADP
dti-1305	329	12	mice	mouse	NOUN
dti-1305	329	13	with	with	ADP
dti-1305	329	14	experimental	experimental	ADJ
dti-1305	329	15	chagas	chagas	NOUN
dti-1305	329	16	disease	disease	NOUN
dti-1305	329	17	(	(	PUNCT
dti-1305	329	18	rivarola	rivarola	VERB
dti-1305	329	19	et	et	PROPN
dti-1305	329	20	al	al	PROPN
dti-1305	329	21	.	.	PROPN
dti-1305	329	22	2001	2001	NUM
dti-1305	329	23	,	,	PUNCT
dti-1305	329	24	2002	2002	NUM
dti-1305	329	25	)	)	PUNCT
dti-1305	329	26	.	.	PUNCT
dti-1305	330	1	the	the	DET
dti-1305	330	2	investigation	investigation	NOUN
dti-1305	330	3	of	of	ADP
dti-1305	330	4	effects	effect	NOUN
dti-1305	330	5	of	of	ADP
dti-1305	330	6	clomipramine	clomipramine	NOUN
dti-1305	330	7	on	on	ADP
dti-1305	330	8	t.	t.	PROPN
dti-1305	330	9	cruzi	cruzi	PROPN
dti-1305	330	10	infected	infect	VERB
dti-1305	330	11	mice	mouse	NOUN
dti-1305	330	12	demonstrated	demonstrate	VERB
dti-1305	330	13	that	that	SCONJ
dti-1305	330	14	clomipramine	clomipramine	NOUN
dti-1305	330	15	at	at	ADP
dti-1305	330	16	5	5	NUM
dti-1305	330	17	mg	mg	PROPN
dti-1305	330	18	/	/	SYM
dti-1305	330	19	kg	kg	PROPN
dti-1305	330	20	daily	daily	ADJ
dti-1305	330	21	doses	dose	NOUN
dti-1305	330	22	for	for	ADP
dti-1305	330	23	30	30	NUM
dti-1305	330	24	days	day	NOUN
dti-1305	330	25	,	,	PUNCT
dti-1305	330	26	or	or	CCONJ
dti-1305	330	27	two	two	NUM
dti-1305	330	28	doses	dose	NOUN
dti-1305	330	29	of	of	ADP
dti-1305	330	30	clomipramine	clomipramine	NOUN
dti-1305	330	31	40	40	NUM
dti-1305	330	32	mg	mg	NUM
dti-1305	330	33	/	/	SYM
dti-1305	330	34	kg	kg	PROPN
dti-1305	330	35	given	give	VERB
dti-1305	330	36	intraperitoneally	intraperitoneally	ADV
dti-1305	330	37	at	at	ADP
dti-1305	330	38	1h	1h	NUM
dti-1305	330	39	and	and	CCONJ
dti-1305	330	40	7	7	NUM
dti-1305	330	41	days	day	NOUN
dti-1305	330	42	after	after	ADP
dti-1305	330	43	infection	infection	NOUN
dti-1305	330	44	,	,	PUNCT
dti-1305	330	45	was	be	AUX
dti-1305	330	46	not	not	PART
dti-1305	330	47	toxic	toxic	ADJ
dti-1305	330	48	for	for	ADP
dti-1305	330	49	the	the	DET
dti-1305	330	50	host	host	NOUN
dti-1305	330	51	,	,	PUNCT
dti-1305	330	52	but	but	CCONJ
dti-1305	330	53	was	be	AUX
dti-1305	330	54	effective	effective	ADJ
dti-1305	330	55	against	against	ADP
dti-1305	330	56	the	the	DET
dti-1305	330	57	parasite	parasite	NOUN
dti-1305	330	58	.	.	PUNCT
dti-1305	331	1	parasitamiasis	parasitamiasis	NOUN
dti-1305	331	2	became	become	VERB
dti-1305	331	3	negative	negative	ADJ
dti-1305	331	4	and	and	CCONJ
dti-1305	331	5	only	only	ADV
dti-1305	331	6	mild	mild	ADJ
dti-1305	331	7	heart	heart	NOUN
dti-1305	331	8	structural	structural	ADJ
dti-1305	331	9	and	and	CCONJ
dti-1305	331	10	elecctrocardiographic	elecctrocardiographic	ADJ
dti-1305	331	11	alterations	alteration	NOUN
dti-1305	331	12	were	be	AUX
dti-1305	331	13	detected	detect	VERB
dti-1305	331	14	in	in	ADP
dti-1305	331	15	chronic	chronic	ADJ
dti-1305	331	16	phase	phase	NOUN
dti-1305	331	17	in	in	ADP
dti-1305	331	18	the	the	DET
dti-1305	331	19	group	group	NOUN
dti-1305	331	20	treated	treat	VERB
dti-1305	331	21	with	with	ADP
dti-1305	331	22	clomipramine	clomipramine	NOUN
dti-1305	331	23	5	5	NUM
dti-1305	331	24	mg	mg	PROPN
dti-1305	331	25	/	/	SYM
dti-1305	331	26	kg	kg	PROPN
dti-1305	331	27	.	.	PUNCT
dti-1305	332	1	in	in	ADP
dti-1305	332	2	mice	mouse	NOUN
dti-1305	332	3	treated	treat	VERB
dti-1305	332	4	with	with	ADP
dti-1305	332	5	40	40	NUM
dti-1305	332	6	mg	mg	NUM
dti-1305	332	7	/	/	SYM
dti-1305	332	8	kg	kg	PROPN
dti-1305	332	9	,	,	PUNCT
dti-1305	332	10	none	none	NOUN
dti-1305	332	11	of	of	ADP
dti-1305	332	12	these	these	DET
dti-1305	332	13	alterations	alteration	NOUN
dti-1305	332	14	was	be	AUX
dti-1305	332	15	detected	detect	VERB
dti-1305	332	16	(	(	PUNCT
dti-1305	332	17	rivarola	rivarola	VERB
dti-1305	332	18	et	et	PROPN
dti-1305	332	19	al	al	PROPN
dti-1305	332	20	.	.	PROPN
dti-1305	332	21	2001	2001	NUM
dti-1305	332	22	)	)	PUNCT
dti-1305	332	23	.	.	PUNCT
dti-1305	333	1	overall	overall	ADV
dti-1305	333	2	,	,	PUNCT
dti-1305	333	3	it	it	PRON
dti-1305	333	4	has	have	AUX
dti-1305	333	5	been	be	AUX
dti-1305	333	6	shown	show	VERB
dti-1305	333	7	that	that	SCONJ
dti-1305	333	8	clomipramine	clomipramine	NOUN
dti-1305	333	9	and	and	CCONJ
dti-1305	333	10	thioridazine	thioridazine	PROPN
dti-1305	333	11	signifi	signifi	NOUN
dti-1305	333	12	cantly	cantly	ADV
dti-1305	333	13	modifi	modifi	PROPN
dti-1305	333	14	ed	ed	PROPN
dti-1305	333	15	the	the	DET
dti-1305	333	16	natural	natural	ADJ
dti-1305	333	17	evolution	evolution	NOUN
dti-1305	333	18	of	of	ADP
dti-1305	333	19	the	the	DET
dti-1305	333	20	infection	infection	NOUN
dti-1305	333	21	.	.	PUNCT
dti-1305	334	1	cardiac	cardiac	ADJ
dti-1305	334	2	function	function	NOUN
dti-1305	334	3	and	and	CCONJ
dti-1305	334	4	survival	survival	NOUN
dti-1305	334	5	of	of	ADP
dti-1305	334	6	infected	infect	VERB
dti-1305	334	7	and	and	CCONJ
dti-1305	334	8	treated	treat	VERB
dti-1305	334	9	animals	animal	NOUN
dti-1305	334	10	were	be	AUX
dti-1305	334	11	not	not	PART
dti-1305	334	12	different	different	ADJ
dti-1305	334	13	from	from	ADP
dti-1305	334	14	noninfected	noninfecte	VERB
dti-1305	334	15	animals	animal	NOUN
dti-1305	334	16	.	.	PUNCT
dti-1305	335	1	thioridazine	thioridazine	PROPN
dti-1305	335	2	or	or	CCONJ
dti-1305	335	3	clomipramine	clomipramine	NOUN
dti-1305	335	4	are	be	AUX
dti-1305	335	5	currently	currently	ADV
dti-1305	335	6	registered	register	VERB
dti-1305	335	7	as	as	ADP
dti-1305	335	8	drugs	drug	NOUN
dti-1305	335	9	(	(	PUNCT
dti-1305	335	10	antipsychotics	antipsychotic	NOUN
dti-1305	335	11	)	)	PUNCT
dti-1305	335	12	and	and	CCONJ
dti-1305	335	13	meet	meet	VERB
dti-1305	335	14	all	all	DET
dti-1305	335	15	the	the	DET
dti-1305	335	16	above	above	ADV
dti-1305	335	17	mentioned	mention	VERB
dti-1305	335	18	criteria	criterion	NOUN
dti-1305	335	19	.	.	PUNCT
dti-1305	336	1	however	however	ADV
dti-1305	336	2	,	,	PUNCT
dti-1305	336	3	to	to	PART
dti-1305	336	4	consider	consider	VERB
dti-1305	336	5	them	they	PRON
dti-1305	336	6	as	as	ADP
dti-1305	336	7	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	336	8	drugs	drug	NOUN
dti-1305	336	9	,	,	PUNCT
dti-1305	336	10	dose	dose	NOUN
dti-1305	336	11	becomes	become	VERB
dti-1305	336	12	an	an	DET
dti-1305	336	13	important	important	ADJ
dti-1305	336	14	obstacle	obstacle	NOUN
dti-1305	336	15	,	,	PUNCT
dti-1305	336	16	since	since	SCONJ
dti-1305	336	17	they	they	PRON
dti-1305	336	18	need	need	VERB
dti-1305	336	19	to	to	PART
dti-1305	336	20	be	be	AUX
dti-1305	336	21	active	active	ADJ
dti-1305	336	22	at	at	ADP
dti-1305	336	23	a	a	DET
dti-1305	336	24	dose	dose	NOUN
dti-1305	336	25	which	which	PRON
dti-1305	336	26	is	be	AUX
dti-1305	336	27	known	know	VERB
dti-1305	336	28	to	to	PART
dti-1305	336	29	be	be	AUX
dti-1305	336	30	tolerated	tolerate	VERB
dti-1305	336	31	by	by	ADP
dti-1305	336	32	psychiatric	psychiatric	ADJ
dti-1305	336	33	patients	patient	NOUN
dti-1305	336	34	without	without	ADP
dti-1305	336	35	causing	cause	VERB
dti-1305	336	36	adverse	adverse	ADJ
dti-1305	336	37	events	event	NOUN
dti-1305	336	38	.	.	PUNCT
dti-1305	337	1	apart	apart	ADV
dti-1305	337	2	from	from	ADP
dti-1305	337	3	their	their	PRON
dti-1305	337	4	potent	potent	NOUN
dti-1305	337	5	in	in	ADP
dti-1305	337	6	vitro	vitro	X
dti-1305	337	7	activity	activity	NOUN
dti-1305	337	8	and	and	CCONJ
dti-1305	337	9	a	a	DET
dti-1305	337	10	preliminary	preliminary	ADJ
dti-1305	337	11	report	report	NOUN
dti-1305	337	12	of	of	ADP
dti-1305	337	13	in	in	ADP
dti-1305	337	14	vivo	vivo	NOUN
dti-1305	337	15	activity	activity	NOUN
dti-1305	337	16	,	,	PUNCT
dti-1305	337	17	more	more	ADJ
dti-1305	337	18	detail	detail	NOUN
dti-1305	337	19	studies	study	NOUN
dti-1305	337	20	are	be	AUX
dti-1305	337	21	needed	need	VERB
dti-1305	337	22	to	to	PART
dti-1305	337	23	establish	establish	VERB
dti-1305	337	24	their	their	PRON
dti-1305	337	25	effi	effi	PROPN
dti-1305	337	26	cacy	cacy	NOUN
dti-1305	337	27	and	and	CCONJ
dti-1305	337	28	safety	safety	NOUN
dti-1305	337	29	and	and	CCONJ
dti-1305	337	30	also	also	ADV
dti-1305	337	31	to	to	PART
dti-1305	337	32	improve	improve	VERB
dti-1305	337	33	their	their	PRON
dti-1305	337	34	antiparasitic	antiparasitic	ADJ
dti-1305	337	35	potency	potency	NOUN
dti-1305	337	36	.	.	PUNCT
dti-1305	338	1	overall	overall	ADV
dti-1305	338	2	,	,	PUNCT
dti-1305	338	3	it	it	PRON
dti-1305	338	4	would	would	AUX
dti-1305	338	5	not	not	PART
dti-1305	338	6	be	be	AUX
dti-1305	338	7	overenthusiastic	overenthusiastic	ADJ
dti-1305	338	8	to	to	PART
dti-1305	338	9	consider	consider	VERB
dti-1305	338	10	phenothiazines	phenothiazine	NOUN
dti-1305	338	11	and	and	CCONJ
dti-1305	338	12	related	relate	VERB
dti-1305	338	13	tricyclic	tricyclic	ADJ
dti-1305	338	14	antidepressants	antidepressant	NOUN
dti-1305	338	15	and	and	CCONJ
dti-1305	338	16	the	the	DET
dti-1305	338	17	other	other	ADJ
dti-1305	338	18	inhibitors	inhibitor	NOUN
dti-1305	338	19	of	of	ADP
dti-1305	338	20	tr	tr	VERB
dti-1305	338	21	as	as	ADP
dti-1305	338	22	important	important	ADJ
dti-1305	338	23	drug	drug	NOUN
dti-1305	338	24	leads	lead	VERB
dti-1305	338	25	for	for	ADP
dti-1305	338	26	development	development	NOUN
dti-1305	338	27	of	of	ADP
dti-1305	338	28	future	future	ADJ
dti-1305	338	29	chemotherapy	chemotherapy	NOUN
dti-1305	338	30	against	against	ADP
dti-1305	338	31	trypanosomal	trypanosomal	ADJ
dti-1305	338	32	and	and	CCONJ
dti-1305	338	33	leishmanial	leishmanial	ADJ
dti-1305	338	34	infections	infection	NOUN
dti-1305	338	35	.	.	PUNCT
dti-1305	339	1	conclusion	conclusion	VERB
dti-1305	339	2	the	the	DET
dti-1305	339	3	demand	demand	NOUN
dti-1305	339	4	for	for	ADP
dti-1305	339	5	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	339	6	agents	agent	NOUN
dti-1305	339	7	for	for	ADP
dti-1305	339	8	the	the	DET
dti-1305	339	9	treatment	treatment	NOUN
dti-1305	339	10	of	of	ADP
dti-1305	339	11	chagas	chagas	NOUN
dti-1305	339	12	disease	disease	NOUN
dti-1305	339	13	,	,	PUNCT
dti-1305	339	14	sleeping	sleep	VERB
dti-1305	339	15	sickness	sickness	NOUN
dti-1305	339	16	and	and	CCONJ
dti-1305	339	17	kala	kala	PROPN
dti-1305	339	18	azar	azar	PROPN
dti-1305	339	19	is	be	AUX
dti-1305	339	20	desperate	desperate	ADJ
dti-1305	339	21	.	.	PUNCT
dti-1305	340	1	an	an	DET
dti-1305	340	2	account	account	NOUN
dti-1305	340	3	of	of	ADP
dti-1305	340	4	the	the	DET
dti-1305	340	5	different	different	ADJ
dti-1305	340	6	possible	possible	ADJ
dti-1305	340	7	targets	target	NOUN
dti-1305	340	8	for	for	ADP
dti-1305	340	9	rational	rational	ADJ
dti-1305	340	10	drug	drug	NOUN
dti-1305	340	11	design	design	NOUN
dti-1305	340	12	with	with	ADP
dti-1305	340	13	special	special	ADJ
dti-1305	340	14	emphasis	emphasis	NOUN
dti-1305	340	15	on	on	ADP
dti-1305	340	16	trypanothione	trypanothione	NOUN
dti-1305	340	17	reductase	reductase	NOUN
dti-1305	340	18	has	have	AUX
dti-1305	340	19	been	be	AUX
dti-1305	340	20	focused	focus	VERB
dti-1305	340	21	.	.	PUNCT
dti-1305	341	1	tr	tr	PRON
dti-1305	341	2	has	have	AUX
dti-1305	341	3	been	be	AUX
dti-1305	341	4	established	establish	VERB
dti-1305	341	5	as	as	ADP
dti-1305	341	6	a	a	DET
dti-1305	341	7	potential	potential	ADJ
dti-1305	341	8	target	target	NOUN
dti-1305	341	9	in	in	ADP
dti-1305	341	10	several	several	ADJ
dti-1305	341	11	studies	study	NOUN
dti-1305	341	12	although	although	SCONJ
dti-1305	341	13	it	it	PRON
dti-1305	341	14	is	be	AUX
dti-1305	341	15	not	not	PART
dti-1305	341	16	universally	universally	ADV
dti-1305	341	17	accepted	accept	VERB
dti-1305	341	18	.	.	PUNCT
dti-1305	342	1	the	the	DET
dti-1305	342	2	literature	literature	NOUN
dti-1305	342	3	,	,	PUNCT
dti-1305	342	4	molecular	molecular	ADJ
dti-1305	342	5	graphics	graphic	NOUN
dti-1305	342	6	and	and	CCONJ
dti-1305	342	7	other	other	ADJ
dti-1305	342	8	medicinal	medicinal	ADJ
dti-1305	342	9	chemistry	chemistry	NOUN
dti-1305	342	10	approaches	approach	NOUN
dti-1305	342	11	have	have	AUX
dti-1305	342	12	led	lead	VERB
dti-1305	342	13	to	to	ADP
dti-1305	342	14	the	the	DET
dti-1305	342	15	development	development	NOUN
dti-1305	342	16	of	of	ADP
dti-1305	342	17	a	a	DET
dti-1305	342	18	large	large	ADJ
dti-1305	342	19	class	class	NOUN
dti-1305	342	20	of	of	ADP
dti-1305	342	21	compounds	compound	NOUN
dti-1305	342	22	as	as	ADP
dti-1305	342	23	inhibitors	inhibitor	NOUN
dti-1305	342	24	of	of	ADP
dti-1305	342	25	tr	tr	VERB
dti-1305	342	26	and	and	CCONJ
dti-1305	342	27	the	the	DET
dti-1305	342	28	parasites	parasite	NOUN
dti-1305	342	29	.	.	PUNCT
dti-1305	343	1	considerable	considerable	ADJ
dti-1305	343	2	progress	progress	NOUN
dti-1305	343	3	have	have	AUX
dti-1305	343	4	been	be	AUX
dti-1305	343	5	made	make	VERB
dti-1305	343	6	in	in	ADP
dti-1305	343	7	terms	term	NOUN
dti-1305	343	8	of	of	ADP
dti-1305	343	9	identifi	identifi	PROPN
dti-1305	343	10	cation	cation	NOUN
dti-1305	343	11	,	,	PUNCT
dti-1305	343	12	validation	validation	NOUN
dti-1305	343	13	and	and	CCONJ
dti-1305	343	14	inhibitor	inhibitor	NOUN
dti-1305	343	15	design	design	NOUN
dti-1305	343	16	based	base	VERB
dti-1305	343	17	on	on	ADP
dti-1305	343	18	trypanothione	trypanothione	PROPN
dti-1305	343	19	reductase	reductase	NOUN
dti-1305	343	20	as	as	ADP
dti-1305	343	21	a	a	DET
dti-1305	343	22	target	target	NOUN
dti-1305	343	23	,	,	PUNCT
dti-1305	343	24	which	which	PRON
dti-1305	343	25	will	will	AUX
dti-1305	343	26	be	be	AUX
dti-1305	343	27	milestones	milestone	NOUN
dti-1305	343	28	towards	towards	ADP
dti-1305	343	29	the	the	DET
dti-1305	343	30	goal	goal	NOUN
dti-1305	343	31	of	of	ADP
dti-1305	343	32	developing	develop	VERB
dti-1305	343	33	chemotherapy	chemotherapy	NOUN
dti-1305	343	34	against	against	ADP
dti-1305	343	35	these	these	DET
dti-1305	343	36	devastating	devastating	ADJ
dti-1305	343	37	diseases	disease	NOUN
dti-1305	343	38	.	.	PUNCT
dti-1305	344	1	this	this	DET
dti-1305	344	2	review	review	NOUN
dti-1305	344	3	has	have	AUX
dti-1305	344	4	revealed	reveal	VERB
dti-1305	344	5	several	several	ADJ
dti-1305	344	6	approaches	approach	NOUN
dti-1305	344	7	based	base	VERB
dti-1305	344	8	on	on	ADP
dti-1305	344	9	tr	tr	VERB
dti-1305	344	10	towards	towards	ADP
dti-1305	344	11	the	the	DET
dti-1305	344	12	development	development	NOUN
dti-1305	344	13	of	of	ADP
dti-1305	344	14	new	new	ADJ
dti-1305	344	15	drugs	drug	NOUN
dti-1305	344	16	against	against	ADP
dti-1305	344	17	the	the	DET
dti-1305	344	18	parasitic	parasitic	ADJ
dti-1305	344	19	diseases	disease	NOUN
dti-1305	344	20	.	.	PUNCT
dti-1305	345	1	reasonable	reasonable	ADJ
dti-1305	345	2	activity	activity	NOUN
dti-1305	345	3	against	against	ADP
dti-1305	345	4	parasites	parasite	NOUN
dti-1305	345	5	living	live	VERB
dti-1305	345	6	in	in	ADP
dti-1305	345	7	both	both	DET
dti-1305	345	8	culture	culture	NOUN
dti-1305	345	9	and	and	CCONJ
dti-1305	345	10	in	in	ADP
dti-1305	345	11	mouse	mouse	NOUN
dti-1305	345	12	macrophases	macrophase	NOUN
dti-1305	345	13	has	have	AUX
dti-1305	345	14	been	be	AUX
dti-1305	345	15	demonstrated	demonstrate	VERB
dti-1305	345	16	by	by	ADP
dti-1305	345	17	most	most	ADJ
dti-1305	345	18	classes	class	NOUN
dti-1305	345	19	of	of	ADP
dti-1305	345	20	compounds	compound	NOUN
dti-1305	345	21	,	,	PUNCT
dti-1305	345	22	full	full	ADJ
dti-1305	345	23	activity	activity	NOUN
dti-1305	345	24	against	against	ADP
dti-1305	345	25	whole	whole	ADJ
dti-1305	345	26	animal	animal	NOUN
dti-1305	345	27	model	model	NOUN
dti-1305	345	28	to	to	PART
dti-1305	345	29	be	be	AUX
dti-1305	345	30	achieved	achieve	VERB
dti-1305	345	31	.	.	PUNCT
dti-1305	346	1	it	it	PRON
dti-1305	346	2	has	have	AUX
dti-1305	346	3	been	be	AUX
dti-1305	346	4	suggested	suggest	VERB
dti-1305	346	5	that	that	SCONJ
dti-1305	346	6	the	the	DET
dti-1305	346	7	alternative	alternative	ADJ
dti-1305	346	8	approaches	approach	NOUN
dti-1305	346	9	like	like	ADP
dti-1305	346	10	subversive	subversive	ADJ
dti-1305	346	11	substrates	substrate	NOUN
dti-1305	346	12	and	and	CCONJ
dti-1305	346	13	metal	metal	NOUN
dti-1305	346	14	bound	bind	VERB
dti-1305	346	15	inhibitors	inhibitor	NOUN
dti-1305	346	16	would	would	AUX
dti-1305	346	17	be	be	AUX
dti-1305	346	18	advantageous	advantageous	ADJ
dti-1305	346	19	in	in	ADP
dti-1305	346	20	achieving	achieve	VERB
dti-1305	346	21	reasonable	reasonable	ADJ
dti-1305	346	22	in	in	ADP
dti-1305	346	23	vivo	vivo	ADJ
dti-1305	346	24	activity	activity	NOUN
dti-1305	346	25	against	against	ADP
dti-1305	346	26	the	the	DET
dti-1305	346	27	parasite	parasite	NOUN
dti-1305	346	28	infection	infection	NOUN
dti-1305	346	29	.	.	PUNCT
dti-1305	347	1	only	only	ADV
dti-1305	347	2	the	the	DET
dti-1305	347	3	phenothiazines	phenothiazine	NOUN
dti-1305	347	4	and	and	CCONJ
dti-1305	347	5	related	relate	VERB
dti-1305	347	6	tricyclic	tricyclic	ADJ
dti-1305	347	7	antidepressants	antidepressant	NOUN
dti-1305	347	8	were	be	AUX
dti-1305	347	9	shown	show	VERB
dti-1305	347	10	to	to	PART
dti-1305	347	11	reduce	reduce	VERB
dti-1305	347	12	parasite	parasite	NOUN
dti-1305	347	13	burden	burden	NOUN
dti-1305	347	14	in	in	ADP
dti-1305	347	15	infected	infected	ADJ
dti-1305	347	16	mice	mouse	NOUN
dti-1305	347	17	.	.	PUNCT
dti-1305	348	1	development	development	NOUN
dti-1305	348	2	of	of	ADP
dti-1305	348	3	the	the	DET
dti-1305	348	4	quaternary	quaternary	ADJ
dti-1305	348	5	alkylammonium	alkylammonium	NOUN
dti-1305	348	6	chlorpromazines	chlorpromazine	NOUN
dti-1305	348	7	and	and	CCONJ
dti-1305	348	8	congeners	congener	NOUN
dti-1305	348	9	,	,	PUNCT
dti-1305	348	10	with	with	ADP
dti-1305	348	11	an	an	DET
dti-1305	348	12	additional	additional	ADJ
dti-1305	348	13	hydrophobic	hydrophobic	NOUN
dti-1305	348	14	moiety	moiety	NOUN
dti-1305	348	15	provided	provide	VERB
dti-1305	348	16	,	,	PUNCT
dti-1305	348	17	on	on	ADP
dti-1305	348	18	an	an	DET
dti-1305	348	19	average	average	NOUN
dti-1305	348	20	,	,	PUNCT
dti-1305	348	21	up	up	ADP
dti-1305	348	22	to	to	ADP
dti-1305	348	23	about	about	ADV
dti-1305	348	24	30	30	NUM
dti-1305	348	25	-	-	NUM
dti-1305	348	26	fold	fold	VERB
dti-1305	348	27	more	more	ADV
dti-1305	348	28	potent	potent	ADJ
dti-1305	348	29	inhibitors	inhibitor	NOUN
dti-1305	348	30	of	of	ADP
dti-1305	348	31	tr	tr	VERB
dti-1305	348	32	.	.	PUNCT
dti-1305	349	1	the	the	DET
dti-1305	349	2	charge	charge	NOUN
dti-1305	349	3	on	on	ADP
dti-1305	349	4	n+	n+	NUM
dti-1305	349	5	is	be	AUX
dti-1305	349	6	needed	need	VERB
dti-1305	349	7	for	for	ADP
dti-1305	349	8	interaction	interaction	NOUN
dti-1305	349	9	at	at	ADP
dti-1305	349	10	the	the	DET
dti-1305	349	11	glu466	glu466	NOUN
dti-1305	349	12	’	'	PUNCT
dti-1305	349	13	or	or	CCONJ
dti-1305	349	14	glu467	glu467	PROPN
dti-1305	349	15	’	'	PUNCT
dti-1305	349	16	of	of	ADP
dti-1305	349	17	the	the	DET
dti-1305	349	18	enzyme	enzyme	NOUN
dti-1305	349	19	active	active	ADJ
dti-1305	349	20	site	site	NOUN
dti-1305	349	21	,	,	PUNCT
dti-1305	349	22	the	the	DET
dti-1305	349	23	tricyclic	tricyclic	ADJ
dti-1305	349	24	or	or	CCONJ
dti-1305	349	25	equivalent	equivalent	ADJ
dti-1305	349	26	moiety	moiety	NOUN
dti-1305	349	27	interacts	interact	VERB
dti-1305	349	28	with	with	ADP
dti-1305	349	29	the	the	DET
dti-1305	349	30	major	major	ADJ
dti-1305	349	31	hydrophobic	hydrophobic	NOUN
dti-1305	349	32	cleft	cleft	NOUN
dti-1305	349	33	and	and	CCONJ
dti-1305	349	34	the	the	DET
dti-1305	349	35	second	second	ADJ
dti-1305	349	36	hydrophobic	hydrophobic	NOUN
dti-1305	349	37	moiety	moiety	NOUN
dti-1305	349	38	may	may	AUX
dti-1305	349	39	interact	interact	VERB
dti-1305	349	40	with	with	ADP
dti-1305	349	41	z	z	NOUN
dti-1305	349	42	-	-	PUNCT
dti-1305	349	43	site	site	NOUN
dti-1305	349	44	.	.	PUNCT
dti-1305	350	1	studies	study	NOUN
dti-1305	350	2	with	with	ADP
dti-1305	350	3	other	other	ADJ
dti-1305	350	4	classes	class	NOUN
dti-1305	350	5	of	of	ADP
dti-1305	350	6	inhibitors	inhibitor	NOUN
dti-1305	350	7	,	,	PUNCT
dti-1305	350	8	in	in	ADP
dti-1305	350	9	addition	addition	NOUN
dti-1305	350	10	to	to	ADP
dti-1305	350	11	the	the	DET
dti-1305	350	12	tr	tr	VERB
dti-1305	350	13	:	:	PUNCT
dti-1305	350	14	inhibitor	inhibitor	NOUN
dti-1305	350	15	complex	complex	NOUN
dti-1305	350	16	’s	’s	PART
dti-1305	350	17	x	x	ADJ
dti-1305	350	18	-	-	NOUN
dti-1305	350	19	ray	ray	NOUN
dti-1305	350	20	crystal	crystal	NOUN
dti-1305	350	21	structure	structure	NOUN
dti-1305	350	22	,	,	PUNCT
dti-1305	350	23	provided	provide	VERB
dti-1305	350	24	similar	similar	ADJ
dti-1305	350	25	tr	tr	VERB
dti-1305	350	26	:	:	PUNCT
dti-1305	350	27	inhibitor	inhibitor	NOUN
dti-1305	350	28	interactive	interactive	ADJ
dti-1305	350	29	motifs	motif	NOUN
dti-1305	350	30	.	.	PUNCT
dti-1305	351	1	as	as	ADP
dti-1305	351	2	with	with	ADP
dti-1305	351	3	any	any	DET
dti-1305	351	4	rational	rational	ADJ
dti-1305	351	5	drug	drug	NOUN
dti-1305	351	6	design	design	NOUN
dti-1305	351	7	case	case	NOUN
dti-1305	351	8	at	at	ADP
dti-1305	351	9	the	the	DET
dti-1305	351	10	current	current	ADJ
dti-1305	351	11	stage	stage	NOUN
dti-1305	351	12	of	of	ADP
dti-1305	351	13	computational	computational	ADJ
dti-1305	351	14	development	development	NOUN
dti-1305	351	15	,	,	PUNCT
dti-1305	351	16	the	the	DET
dti-1305	351	17	problem	problem	NOUN
dti-1305	351	18	of	of	ADP
dti-1305	351	19	bioavailability	bioavailability	NOUN
dti-1305	351	20	,	,	PUNCT
dti-1305	351	21	pharmacokinetic	pharmacokinetic	NOUN
dti-1305	351	22	,	,	PUNCT
dti-1305	351	23	metabolism	metabolism	NOUN
dti-1305	351	24	and	and	CCONJ
dti-1305	351	25	targeting	targeting	NOUN
dti-1305	351	26	have	have	AUX
dti-1305	351	27	not	not	PART
dti-1305	351	28	been	be	AUX
dti-1305	351	29	addressed	address	VERB
dti-1305	351	30	.	.	PUNCT
dti-1305	352	1	the	the	DET
dti-1305	352	2	prodrug	prodrug	NOUN
dti-1305	352	3	approach	approach	NOUN
dti-1305	352	4	might	might	AUX
dti-1305	352	5	be	be	AUX
dti-1305	352	6	a	a	DET
dti-1305	352	7	reasonable	reasonable	ADJ
dti-1305	352	8	step	step	NOUN
dti-1305	352	9	in	in	ADP
dti-1305	352	10	correcting	correct	VERB
dti-1305	352	11	some	some	PRON
dti-1305	352	12	of	of	ADP
dti-1305	352	13	the	the	DET
dti-1305	352	14	aforementioned	aforementione	VERB
dti-1305	352	15	problems	problem	NOUN
dti-1305	352	16	in	in	ADP
dti-1305	352	17	developing	develop	VERB
dti-1305	352	18	tr	tr	NOUN
dti-1305	352	19	inhibitors	inhibitor	NOUN
dti-1305	352	20	with	with	ADP
dti-1305	352	21	observable	observable	ADJ
dti-1305	352	22	effects	effect	NOUN
dti-1305	352	23	in	in	ADP
dti-1305	352	24	vivo	vivo	NOUN
dti-1305	352	25	and	and	CCONJ
dti-1305	352	26	might	might	AUX
dti-1305	352	27	open	open	VERB
dti-1305	352	28	a	a	DET
dti-1305	352	29	new	new	ADJ
dti-1305	352	30	path	path	NOUN
dti-1305	352	31	towards	towards	ADP
dti-1305	352	32	the	the	DET
dti-1305	352	33	development	development	NOUN
dti-1305	352	34	of	of	ADP
dti-1305	352	35	drugs	drug	NOUN
dti-1305	352	36	against	against	ADP
dti-1305	352	37	these	these	DET
dti-1305	352	38	parasitic	parasitic	ADJ
dti-1305	352	39	diseases	disease	NOUN
dti-1305	352	40	.	.	PUNCT
dti-1305	353	1	acknowledgements	acknowledgement	NOUN
dti-1305	353	2	the	the	DET
dti-1305	353	3	author	author	NOUN
dti-1305	353	4	wish	wish	VERB
dti-1305	353	5	to	to	PART
dti-1305	353	6	gratefully	gratefully	VERB
dti-1305	353	7	acknowledge	acknowledge	VERB
dti-1305	353	8	professors	professor	NOUN
dti-1305	354	1	k.	k.	PROPN
dti-1305	354	2	t.	t.	PROPN
dti-1305	354	3	douglas	douglas	PROPN
dti-1305	354	4	of	of	ADP
dti-1305	354	5	manchester	manchester	PROPN
dti-1305	354	6	,	,	PUNCT
dti-1305	354	7	a.	a.	PROPN
dti-1305	354	8	h.	h.	PROPN
dti-1305	354	9	fairlamb	fairlamb	PROPN
dti-1305	354	10	of	of	ADP
dti-1305	354	11	dundee	dundee	PROPN
dti-1305	354	12	and	and	CCONJ
dti-1305	354	13	r.	r.	PROPN
dti-1305	354	14	l.	l.	PROPN
dti-1305	354	15	krauth	krauth	PROPN
dti-1305	354	16	-	-	PUNCT
dti-1305	354	17	siegel	siegel	PROPN
dti-1305	354	18	of	of	ADP
dti-1305	354	19	heidelberg	heidelberg	PROPN
dti-1305	354	20	and	and	CCONJ
dti-1305	354	21	others	other	NOUN
dti-1305	354	22	who	who	PRON
dti-1305	354	23	are	be	AUX
dti-1305	354	24	pioneering	pioneer	VERB
dti-1305	354	25	the	the	DET
dti-1305	354	26	drug	drug	NOUN
dti-1305	354	27	target	target	NOUN
dti-1305	354	28	insights	insight	NOUN
dti-1305	354	29	2007	2007	NUM
dti-1305	354	30	:	:	PUNCT
dti-1305	354	31	2	2	NUM
dti-1305	354	32	144	144	NUM
dti-1305	354	33	khan	khan	PROPN
dti-1305	354	34	research	research	NOUN
dti-1305	354	35	in	in	ADP
dti-1305	354	36	the	the	DET
dti-1305	354	37	endeavor	endeavor	NOUN
dti-1305	354	38	of	of	ADP
dti-1305	354	39	trypanothione	trypanothione	NOUN
dti-1305	354	40	reductase	reductase	NOUN
dti-1305	354	41	and	and	CCONJ
dti-1305	354	42	many	many	ADJ
dti-1305	354	43	of	of	ADP
dti-1305	354	44	their	their	PRON
dti-1305	354	45	research	research	NOUN
dti-1305	354	46	have	have	AUX
dti-1305	354	47	been	be	AUX
dti-1305	354	48	cited	cite	VERB
dti-1305	354	49	in	in	ADP
dti-1305	354	50	this	this	DET
dti-1305	354	51	review	review	NOUN
dti-1305	354	52	.	.	PUNCT
dti-1305	355	1	references	reference	NOUN
dti-1305	355	2	austin	austin	PROPN
dti-1305	355	3	,	,	PUNCT
dti-1305	355	4	s.e	s.e	PROPN
dti-1305	355	5	.	.	PROPN
dti-1305	355	6	,	,	PUNCT
dti-1305	355	7	khan	khan	PROPN
dti-1305	355	8	,	,	PUNCT
dti-1305	355	9	m.o.f	m.o.f	ADJ
dti-1305	355	10	.	.	PUNCT
dti-1305	355	11	and	and	CCONJ
dti-1305	355	12	douglas	douglas	PROPN
dti-1305	355	13	,	,	PUNCT
dti-1305	355	14	k.t	k.t	PROPN
dti-1305	355	15	.	.	PROPN
dti-1305	355	16	1999	1999	NUM
dti-1305	355	17	.	.	PUNCT
dti-1305	356	1	rational	rational	ADJ
dti-1305	356	2	drug	drug	NOUN
dti-1305	356	3	design	design	NOUN
dti-1305	356	4	using	use	VERB
dti-1305	356	5	trypanothione	trypanothione	NOUN
dti-1305	356	6	reductase	reductase	NOUN
dti-1305	356	7	as	as	ADP
dti-1305	356	8	a	a	DET
dti-1305	356	9	target	target	NOUN
dti-1305	356	10	for	for	ADP
dti-1305	356	11	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	356	12	and	and	CCONJ
dti-1305	356	13	anti	anti	ADJ
dti-1305	356	14	-	-	ADJ
dti-1305	356	15	leishmanial	leishmanial	ADJ
dti-1305	356	16	drug	drug	NOUN
dti-1305	356	17	leads	lead	NOUN
dti-1305	356	18	.	.	PUNCT
dti-1305	357	1	drug	drug	PROPN
dti-1305	357	2	des	des	PROPN
dti-1305	357	3	.	.	PROPN
dti-1305	357	4	discov	discov	PROPN
dti-1305	357	5	.	.	PUNCT
dti-1305	358	1	,	,	PUNCT
dti-1305	358	2	16:5–23	16:5–23	X
dti-1305	358	3	.	.	PUNCT
dti-1305	359	1	bailey	bailey	PROPN
dti-1305	359	2	,	,	PUNCT
dti-1305	359	3	s.	s.	PROPN
dti-1305	359	4	,	,	PUNCT
dti-1305	359	5	smith	smith	PROPN
dti-1305	359	6	,	,	PUNCT
dti-1305	359	7	k.	k.	PROPN
dti-1305	359	8	,	,	PUNCT
dti-1305	359	9	fairlamb	fairlamb	PROPN
dti-1305	359	10	,	,	PUNCT
dti-1305	359	11	a.h	a.h	PROPN
dti-1305	359	12	.	.	PROPN
dti-1305	359	13	et	et	PROPN
dti-1305	359	14	al	al	PROPN
dti-1305	359	15	.	.	PROPN
dti-1305	359	16	1993	1993	NUM
dti-1305	359	17	.	.	PUNCT
dti-1305	360	1	substrate	substrate	NOUN
dti-1305	360	2	interactions	interaction	NOUN
dti-1305	360	3	between	between	ADP
dti-1305	360	4	trypanothione	trypanothione	NOUN
dti-1305	360	5	reductase	reductase	NOUN
dti-1305	360	6	and	and	CCONJ
dti-1305	360	7	n1	n1	NOUN
dti-1305	360	8	-	-	PUNCT
dti-1305	360	9	glutathionylspermidine	glutathionylspermidine	NOUN
dti-1305	360	10	disulphide	disulphide	ADV
dti-1305	360	11	at	at	ADP
dti-1305	360	12	0.28	0.28	NUM
dti-1305	360	13	-	-	PUNCT
dti-1305	360	14	nm	nm	NOUN
dti-1305	360	15	resolution	resolution	NOUN
dti-1305	360	16	.	.	PUNCT
dti-1305	361	1	eur	eur	PROPN
dti-1305	361	2	.	.	PUNCT
dti-1305	362	1	j.	j.	PROPN
dti-1305	362	2	biochem	biochem	PROPN
dti-1305	362	3	.	.	PUNCT
dti-1305	363	1	/	/	PUNCT
dti-1305	363	2	febs	febs	NOUN
dti-1305	363	3	,	,	PUNCT
dti-1305	363	4	213:67–75	213:67–75	X
dti-1305	363	5	.	.	PROPN
dti-1305	363	6	baillet	baillet	PROPN
dti-1305	363	7	,	,	PUNCT
dti-1305	363	8	s.	s.	PROPN
dti-1305	363	9	,	,	PUNCT
dti-1305	363	10	buisine	buisine	PROPN
dti-1305	363	11	,	,	PUNCT
dti-1305	363	12	e.	e.	PROPN
dti-1305	363	13	,	,	PUNCT
dti-1305	363	14	horvath	horvath	PROPN
dti-1305	363	15	,	,	PUNCT
dti-1305	363	16	d.	d.	PROPN
dti-1305	363	17	et	et	PROPN
dti-1305	363	18	al	al	PROPN
dti-1305	363	19	.	.	PROPN
dti-1305	363	20	1996	1996	NUM
dti-1305	363	21	.	.	PUNCT
dti-1305	364	1	2	2	NUM
dti-1305	364	2	-	-	PUNCT
dti-1305	364	3	amino	amino	NOUN
dti-1305	364	4	diphenylsulfi	diphenylsulfi	NOUN
dti-1305	364	5	des	de	NOUN
dti-1305	364	6	as	as	ADP
dti-1305	364	7	inhibitors	inhibitor	NOUN
dti-1305	364	8	of	of	ADP
dti-1305	364	9	trypanothione	trypanothione	NOUN
dti-1305	364	10	reductase	reductase	NOUN
dti-1305	364	11	:	:	PUNCT
dti-1305	364	12	modifi	modifi	NOUN
dti-1305	364	13	cation	cation	NOUN
dti-1305	364	14	of	of	ADP
dti-1305	364	15	the	the	DET
dti-1305	364	16	side	side	NOUN
dti-1305	364	17	chain	chain	NOUN
dti-1305	364	18	.	.	PUNCT
dti-1305	365	1	bioorg	bioorg	PROPN
dti-1305	365	2	.	.	PUNCT
dti-1305	366	1	med	med	PROPN
dti-1305	366	2	.	.	PROPN
dti-1305	366	3	chem	chem	PROPN
dti-1305	366	4	.	.	PUNCT
dti-1305	366	5	,	,	PUNCT
dti-1305	367	1	4:891–9	4:891–9	NUM
dti-1305	367	2	.	.	PUNCT
dti-1305	368	1	benson	benson	PROPN
dti-1305	368	2	,	,	PUNCT
dti-1305	368	3	t.j	t.j	PROPN
dti-1305	368	4	.	.	PROPN
dti-1305	368	5	,	,	PUNCT
dti-1305	368	6	mckie	mckie	PROPN
dti-1305	368	7	,	,	PUNCT
dti-1305	368	8	j.h	j.h	PROPN
dti-1305	368	9	.	.	PROPN
dti-1305	368	10	,	,	PUNCT
dti-1305	368	11	garforth	garforth	PROPN
dti-1305	368	12	,	,	PUNCT
dti-1305	368	13	j.	j.	PROPN
dti-1305	368	14	et	et	PROPN
dti-1305	368	15	al	al	PROPN
dti-1305	368	16	.	.	PROPN
dti-1305	368	17	1992	1992	NUM
dti-1305	368	18	.	.	PUNCT
dti-1305	369	1	rationally	rationally	ADV
dti-1305	369	2	designed	design	VERB
dti-1305	369	3	selective	selective	ADJ
dti-1305	369	4	inhibitors	inhibitor	NOUN
dti-1305	369	5	of	of	ADP
dti-1305	369	6	trypanothione	trypanothione	NOUN
dti-1305	369	7	reductase	reductase	NOUN
dti-1305	369	8	.	.	PUNCT
dti-1305	370	1	phenothiazines	phenothiazine	NOUN
dti-1305	370	2	and	and	CCONJ
dti-1305	370	3	related	related	ADJ
dti-1305	370	4	tricyclics	tricyclic	NOUN
dti-1305	370	5	as	as	ADP
dti-1305	370	6	lead	lead	NOUN
dti-1305	370	7	structures	structure	NOUN
dti-1305	370	8	.	.	PUNCT
dti-1305	371	1	biochem	biochem	PROPN
dti-1305	371	2	.	.	PUNCT
dti-1305	372	1	j.	j.	PROPN
dti-1305	372	2	,	,	PUNCT
dti-1305	372	3	286:9–11	286:9–11	NUM
dti-1305	372	4	.	.	PUNCT
dti-1305	372	5	bi	bi	NOUN
dti-1305	372	6	,	,	PUNCT
dti-1305	372	7	x.	x.	NOUN
dti-1305	372	8	,	,	PUNCT
dti-1305	372	9	lopez	lopez	PROPN
dti-1305	372	10	,	,	PUNCT
dti-1305	372	11	c.	c.	NOUN
dti-1305	372	12	,	,	PUNCT
dti-1305	372	13	bacchi	bacchi	PROPN
dti-1305	372	14	,	,	PUNCT
dti-1305	372	15	c.j	c.j	PROPN
dti-1305	372	16	.	.	PROPN
dti-1305	372	17	et	et	PROPN
dti-1305	372	18	al	al	PROPN
dti-1305	372	19	.	.	PROPN
dti-1305	372	20	2006	2006	NUM
dti-1305	372	21	.	.	PUNCT
dti-1305	373	1	novel	novel	ADJ
dti-1305	373	2	alkylpolyaminoguanidines	alkylpolyaminoguanidine	NOUN
dti-1305	373	3	and	and	CCONJ
dti-1305	373	4	alkylpolyaminobiguanides	alkylpolyaminobiguanide	NOUN
dti-1305	373	5	with	with	ADP
dti-1305	373	6	potent	potent	ADJ
dti-1305	373	7	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	373	8	activity	activity	NOUN
dti-1305	373	9	.	.	PUNCT
dti-1305	374	1	bioorg	bioorg	PROPN
dti-1305	374	2	.	.	PUNCT
dti-1305	375	1	med	med	PROPN
dti-1305	375	2	.	.	PROPN
dti-1305	375	3	chem	chem	PROPN
dti-1305	375	4	.	.	PUNCT
dti-1305	376	1	lett	lett	PROPN
dti-1305	376	2	.	.	PROPN
dti-1305	376	3	,	,	PUNCT
dti-1305	376	4	16:3229–32	16:3229–32	NUM
dti-1305	376	5	.	.	PUNCT
dti-1305	377	1	bodley	bodley	NOUN
dti-1305	377	2	,	,	PUNCT
dti-1305	377	3	a.l	a.l	PROPN
dti-1305	377	4	.	.	PROPN
dti-1305	377	5	,	,	PUNCT
dti-1305	377	6	wani	wani	PROPN
dti-1305	377	7	,	,	PUNCT
dti-1305	377	8	m.c	m.c	PROPN
dti-1305	377	9	.	.	PROPN
dti-1305	377	10	,	,	PUNCT
dti-1305	377	11	wall	wall	PROPN
dti-1305	377	12	,	,	PUNCT
dti-1305	377	13	m.e	m.e	PROPN
dti-1305	377	14	.	.	PROPN
dti-1305	377	15	et	et	PROPN
dti-1305	377	16	al	al	PROPN
dti-1305	377	17	.	.	PROPN
dti-1305	377	18	1995	1995	NUM
dti-1305	377	19	.	.	PUNCT
dti-1305	378	1	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	378	2	activity	activity	NOUN
dti-1305	378	3	of	of	ADP
dti-1305	378	4	camptothecin	camptothecin	NOUN
dti-1305	378	5	analogs	analog	NOUN
dti-1305	378	6	.	.	PUNCT
dti-1305	379	1	structure	structure	NOUN
dti-1305	379	2	-	-	PUNCT
dti-1305	379	3	activity	activity	NOUN
dti-1305	379	4	correlations	correlation	NOUN
dti-1305	379	5	.	.	PUNCT
dti-1305	380	1	biochem	biochem	PROPN
dti-1305	380	2	.	.	PUNCT
dti-1305	381	1	pharmacol	pharmacol	PROPN
dti-1305	381	2	.	.	PROPN
dti-1305	381	3	,	,	PUNCT
dti-1305	381	4	50:937–42	50:937–42	NOUN
dti-1305	381	5	.	.	PUNCT
dti-1305	382	1	bond	bond	NOUN
dti-1305	382	2	,	,	PUNCT
dti-1305	382	3	c.s	c.s	PROPN
dti-1305	382	4	.	.	PROPN
dti-1305	382	5	,	,	PUNCT
dti-1305	382	6	zhang	zhang	PROPN
dti-1305	382	7	,	,	PUNCT
dti-1305	382	8	y.	y.	PROPN
dti-1305	382	9	,	,	PUNCT
dti-1305	382	10	berriman	berriman	NOUN
dti-1305	382	11	,	,	PUNCT
dti-1305	382	12	m.	m.	NOUN
dti-1305	382	13	et	et	PROPN
dti-1305	382	14	al	al	PROPN
dti-1305	382	15	.	.	PROPN
dti-1305	382	16	1999	1999	NUM
dti-1305	382	17	.	.	PUNCT
dti-1305	383	1	crystal	crystal	NOUN
dti-1305	383	2	structure	structure	NOUN
dti-1305	383	3	of	of	ADP
dti-1305	383	4	trypanosoma	trypanosoma	PROPN
dti-1305	383	5	cruzi	cruzi	PROPN
dti-1305	383	6	trypanothione	trypanothione	PROPN
dti-1305	383	7	reductase	reductase	NOUN
dti-1305	383	8	in	in	ADP
dti-1305	383	9	complex	complex	NOUN
dti-1305	383	10	with	with	ADP
dti-1305	383	11	trypanothione	trypanothione	NOUN
dti-1305	383	12	,	,	PUNCT
dti-1305	383	13	and	and	CCONJ
dti-1305	383	14	the	the	DET
dti-1305	383	15	structure	structure	NOUN
dti-1305	383	16	-	-	PUNCT
dti-1305	383	17	based	base	VERB
dti-1305	383	18	discovery	discovery	NOUN
dti-1305	383	19	of	of	ADP
dti-1305	383	20	new	new	ADJ
dti-1305	383	21	natural	natural	ADJ
dti-1305	383	22	product	product	NOUN
dti-1305	383	23	inhibitors	inhibitor	NOUN
dti-1305	383	24	.	.	PUNCT
dti-1305	384	1	structure	structure	NOUN
dti-1305	384	2	,	,	PUNCT
dti-1305	384	3	7:81–9	7:81–9	NUM
dti-1305	384	4	.	.	PUNCT
dti-1305	385	1	bonse	bonse	NOUN
dti-1305	385	2	,	,	PUNCT
dti-1305	385	3	s.	s.	PROPN
dti-1305	385	4	,	,	PUNCT
dti-1305	385	5	santelli	santelli	NOUN
dti-1305	385	6	-	-	PUNCT
dti-1305	385	7	rouvier	rouvier	NOUN
dti-1305	385	8	,	,	PUNCT
dti-1305	385	9	c.	c.	PROPN
dti-1305	385	10	,	,	PUNCT
dti-1305	385	11	barbe	barbe	PROPN
dti-1305	385	12	,	,	PUNCT
dti-1305	385	13	j.	j.	PROPN
dti-1305	385	14	et	et	PROPN
dti-1305	385	15	al	al	PROPN
dti-1305	385	16	.	.	PROPN
dti-1305	385	17	1999	1999	NUM
dti-1305	385	18	.	.	PUNCT
dti-1305	386	1	inhibition	inhibition	NOUN
dti-1305	386	2	of	of	ADP
dti-1305	386	3	trypanosoma	trypanosoma	NOUN
dti-1305	386	4	cruzi	cruzi	PROPN
dti-1305	386	5	trypanothione	trypanothione	PROPN
dti-1305	386	6	reductase	reductase	NOUN
dti-1305	386	7	by	by	ADP
dti-1305	386	8	acridines	acridine	NOUN
dti-1305	386	9	:	:	PUNCT
dti-1305	386	10	kinetic	kinetic	ADJ
dti-1305	386	11	studies	study	NOUN
dti-1305	386	12	and	and	CCONJ
dti-1305	386	13	structure	structure	NOUN
dti-1305	386	14	-	-	PUNCT
dti-1305	386	15	activity	activity	NOUN
dti-1305	386	16	relationships	relationship	NOUN
dti-1305	386	17	.	.	PUNCT
dti-1305	387	1	j.	j.	PROPN
dti-1305	387	2	med	med	PROPN
dti-1305	387	3	.	.	PROPN
dti-1305	387	4	chem	chem	PROPN
dti-1305	387	5	.	.	PUNCT
dti-1305	387	6	,	,	PUNCT
dti-1305	387	7	42:5448–54	42:5448–54	NUM
dti-1305	387	8	.	.	PUNCT
dti-1305	388	1	bonse	bonse	NOUN
dti-1305	388	2	,	,	PUNCT
dti-1305	388	3	s.	s.	PROPN
dti-1305	388	4	,	,	PUNCT
dti-1305	388	5	richards	richards	PROPN
dti-1305	388	6	,	,	PUNCT
dti-1305	388	7	j.m	j.m	PROPN
dti-1305	388	8	.	.	PROPN
dti-1305	388	9	,	,	PUNCT
dti-1305	388	10	ross	ross	PROPN
dti-1305	388	11	,	,	PUNCT
dti-1305	388	12	s.a	s.a	PROPN
dti-1305	388	13	.	.	PROPN
dti-1305	388	14	et	et	PROPN
dti-1305	388	15	al	al	PROPN
dti-1305	388	16	.	.	PROPN
dti-1305	388	17	2000	2000	NUM
dti-1305	388	18	.	.	PUNCT
dti-1305	389	1	(	(	PUNCT
dti-1305	389	2	2,2’:6’,2”terpyridine)platinum(ii	2,2’:6’,2”terpyridine)platinum(ii	NUM
dti-1305	389	3	)	)	PUNCT
dti-1305	389	4	complexes	complex	NOUN
dti-1305	389	5	are	be	AUX
dti-1305	389	6	irreversible	irreversible	ADJ
dti-1305	389	7	inhibitors	inhibitor	NOUN
dti-1305	389	8	of	of	ADP
dti-1305	389	9	trypanosoma	trypanosoma	NOUN
dti-1305	389	10	cruzi	cruzi	PROPN
dti-1305	389	11	trypanothione	trypanothione	PROPN
dti-1305	389	12	reductase	reductase	NOUN
dti-1305	389	13	but	but	CCONJ
dti-1305	389	14	not	not	PART
dti-1305	389	15	of	of	ADP
dti-1305	389	16	human	human	ADJ
dti-1305	389	17	glutathione	glutathione	NOUN
dti-1305	389	18	reductase	reductase	NOUN
dti-1305	389	19	.	.	PUNCT
dti-1305	390	1	j.	j.	PROPN
dti-1305	390	2	med	med	PROPN
dti-1305	390	3	.	.	PROPN
dti-1305	390	4	chem	chem	PROPN
dti-1305	390	5	.	.	PUNCT
dti-1305	390	6	,	,	PUNCT
dti-1305	390	7	43:4812–21	43:4812–21	PROPN
dti-1305	390	8	.	.	PUNCT
dti-1305	391	1	brown	brown	PROPN
dti-1305	391	2	,	,	PUNCT
dti-1305	391	3	j.r	j.r	PROPN
dti-1305	391	4	.	.	PROPN
dti-1305	391	5	1987	1987	NUM
dti-1305	391	6	.	.	PUNCT
dti-1305	392	1	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	392	2	and	and	CCONJ
dti-1305	392	3	leishmaniasis	leishmaniasis	NOUN
dti-1305	392	4	.	.	PUNCT
dti-1305	393	1	in	in	ADP
dti-1305	393	2	critical	critical	ADJ
dti-1305	393	3	reports	report	NOUN
dti-1305	393	4	on	on	ADP
dti-1305	393	5	applied	applied	ADJ
dti-1305	393	6	chemistry	chemistry	NOUN
dti-1305	393	7	,	,	PUNCT
dti-1305	393	8	vol	vol	VERB
dti-1305	393	9	21(chemother	21(chemother	NUM
dti-1305	393	10	trop	trop	X
dti-1305	393	11	dis	dis	PROPN
dti-1305	393	12	)	)	PUNCT
dti-1305	393	13	,	,	PUNCT
dti-1305	394	1	pp72–101	pp72–101	PROPN
dti-1305	394	2	.	.	PUNCT
dti-1305	394	3	brohn	brohn	PROPN
dti-1305	394	4	,	,	PUNCT
dti-1305	394	5	f.h	f.h	PROPN
dti-1305	394	6	.	.	PROPN
dti-1305	394	7	and	and	CCONJ
dti-1305	394	8	clarkson	clarkson	PROPN
dti-1305	394	9	,	,	PUNCT
dti-1305	394	10	a.b.jr	a.b.jr	PROPN
dti-1305	394	11	.	.	PROPN
dti-1305	394	12	,	,	PUNCT
dti-1305	394	13	1980	1980	NUM
dti-1305	394	14	.	.	PUNCT
dti-1305	395	1	trypanosoma	trypanosoma	PROPN
dti-1305	395	2	brucei	brucei	PROPN
dti-1305	395	3	brucei	brucei	PROPN
dti-1305	395	4	:	:	PUNCT
dti-1305	395	5	patterns	pattern	NOUN
dti-1305	395	6	of	of	ADP
dti-1305	395	7	glycolysis	glycolysis	NOUN
dti-1305	395	8	at	at	ADP
dti-1305	395	9	37	37	NUM
dti-1305	395	10	°	°	ADP
dti-1305	395	11	c	c	NOUN
dti-1305	395	12	in	in	ADP
dti-1305	395	13	vitro	vitro	X
dti-1305	395	14	.	.	PUNCT
dti-1305	396	1	mol	mol	PROPN
dti-1305	396	2	.	.	PROPN
dti-1305	396	3	biochem	biochem	PROPN
dti-1305	396	4	.	.	PUNCT
dti-1305	397	1	parasitol	parasitol	NOUN
dti-1305	397	2	.	.	PUNCT
dti-1305	397	3	,	,	PUNCT
dti-1305	398	1	15:291–305	15:291–305	PROPN
dti-1305	398	2	.	.	PUNCT
dti-1305	399	1	carnieri	carnieri	PROPN
dti-1305	399	2	,	,	PUNCT
dti-1305	399	3	e.g.	e.g.	ADV
dti-1305	399	4	,	,	PUNCT
dti-1305	399	5	moreno	moreno	PROPN
dti-1305	399	6	,	,	PUNCT
dti-1305	399	7	s.n	s.n	PROPN
dti-1305	399	8	.	.	PROPN
dti-1305	399	9	and	and	CCONJ
dti-1305	399	10	docampo	docampo	PROPN
dti-1305	399	11	,	,	PUNCT
dti-1305	399	12	r.	r.	PROPN
dti-1305	399	13	1993	1993	NUM
dti-1305	399	14	.	.	PUNCT
dti-1305	400	1	trypanothione	trypanothione	NOUN
dti-1305	400	2	-	-	PUNCT
dti-1305	400	3	dependent	dependent	ADJ
dti-1305	400	4	peroxide	peroxide	NOUN
dti-1305	400	5	metabolism	metabolism	NOUN
dti-1305	400	6	in	in	ADP
dti-1305	400	7	trypanosoma	trypanosoma	PROPN
dti-1305	400	8	cruz	cruz	PROPN
dti-1305	400	9	different	different	ADJ
dti-1305	400	10	stages	stage	NOUN
dti-1305	400	11	.	.	PUNCT
dti-1305	401	1	mol	mol	PROPN
dti-1305	401	2	.	.	PROPN
dti-1305	401	3	biochem	biochem	PROPN
dti-1305	401	4	.	.	PUNCT
dti-1305	402	1	parasitol	parasitol	NOUN
dti-1305	402	2	.	.	PUNCT
dti-1305	402	3	,	,	PUNCT
dti-1305	403	1	61:79–86	61:79–86	NUM
dti-1305	403	2	.	.	PUNCT
dti-1305	404	1	cenas	cenas	PROPN
dti-1305	404	2	,	,	PUNCT
dti-1305	404	3	n.	n.	PROPN
dti-1305	404	4	,	,	PUNCT
dti-1305	404	5	bironaite	bironaite	NOUN
dti-1305	404	6	,	,	PUNCT
dti-1305	404	7	d.	d.	PROPN
dti-1305	404	8	,	,	PUNCT
dti-1305	404	9	dickancaite	dickancaite	PROPN
dti-1305	404	10	,	,	PUNCT
dti-1305	404	11	e.	e.	PROPN
dti-1305	404	12	et	et	PROPN
dti-1305	404	13	al	al	PROPN
dti-1305	404	14	.	.	PROPN
dti-1305	404	15	1994a	1994a	NUM
dti-1305	404	16	.	.	PUNCT
dti-1305	405	1	chinifur	chinifur	NOUN
dti-1305	405	2	,	,	PUNCT
dti-1305	405	3	a	a	DET
dti-1305	405	4	selective	selective	ADJ
dti-1305	405	5	inhibitor	inhibitor	NOUN
dti-1305	405	6	and	and	CCONJ
dti-1305	405	7	“	"	PUNCT
dti-1305	405	8	subversive	subversive	ADJ
dti-1305	405	9	substrate	substrate	NOUN
dti-1305	405	10	”	"	PUNCT
dti-1305	405	11	for	for	ADP
dti-1305	405	12	trypanosoma	trypanosoma	NOUN
dti-1305	405	13	congolense	congolense	PROPN
dti-1305	405	14	trypanothione	trypanothione	PROPN
dti-1305	405	15	reductase	reductase	NOUN
dti-1305	405	16	.	.	PUNCT
dti-1305	406	1	biochem	biochem	PROPN
dti-1305	406	2	.	.	PUNCT
dti-1305	407	1	biophys	biophy	NOUN
dti-1305	407	2	.	.	PUNCT
dti-1305	408	1	res	re	NOUN
dti-1305	408	2	.	.	PROPN
dti-1305	408	3	comm	comm	NOUN
dti-1305	408	4	.	.	PUNCT
dti-1305	408	5	,	,	PUNCT
dti-1305	409	1	204:224–9	204:224–9	NUM
dti-1305	409	2	.	.	PUNCT
dti-1305	410	1	cenas	cenas	PROPN
dti-1305	410	2	,	,	PUNCT
dti-1305	410	3	n.k	n.k	PROPN
dti-1305	410	4	.	.	PROPN
dti-1305	410	5	,	,	PUNCT
dti-1305	410	6	arscott	arscott	PROPN
dti-1305	410	7	,	,	PUNCT
dti-1305	410	8	d.	d.	PROPN
dti-1305	410	9	,	,	PUNCT
dti-1305	410	10	williams	williams	PROPN
dti-1305	410	11	,	,	PUNCT
dti-1305	410	12	chjr	chjr	NOUN
dti-1305	410	13	.	.	PUNCT
dti-1305	411	1	et	et	PROPN
dti-1305	411	2	al	al	PROPN
dti-1305	411	3	.	.	PROPN
dti-1305	411	4	1994b	1994b	NUM
dti-1305	411	5	.	.	PUNCT
dti-1305	412	1	mechanism	mechanism	NOUN
dti-1305	412	2	of	of	ADP
dti-1305	412	3	reduction	reduction	NOUN
dti-1305	412	4	of	of	ADP
dti-1305	412	5	quinones	quinone	NOUN
dti-1305	412	6	by	by	ADP
dti-1305	412	7	trypanosoma	trypanosoma	PROPN
dti-1305	412	8	congolense	congolense	PROPN
dti-1305	412	9	trypanothione	trypanothione	PROPN
dti-1305	412	10	reductase	reductase	NOUN
dti-1305	412	11	.	.	PUNCT
dti-1305	413	1	biochemistry	biochemistry	NOUN
dti-1305	413	2	,	,	PUNCT
dti-1305	413	3	33:2509–15	33:2509–15	NUM
dti-1305	413	4	.	.	PUNCT
dti-1305	413	5	chan	chan	PROPN
dti-1305	413	6	,	,	PUNCT
dti-1305	413	7	c.	c.	PROPN
dti-1305	413	8	,	,	PUNCT
dti-1305	413	9	yin	yin	PROPN
dti-1305	413	10	,	,	PUNCT
dti-1305	413	11	h.	h.	PROPN
dti-1305	413	12	,	,	PUNCT
dti-1305	413	13	garforth	garforth	PROPN
dti-1305	413	14	,	,	PUNCT
dti-1305	413	15	j.	j.	PROPN
dti-1305	413	16	et	et	PROPN
dti-1305	413	17	al	al	PROPN
dti-1305	413	18	.	.	PROPN
dti-1305	413	19	1998	1998	NUM
dti-1305	413	20	.	.	PUNCT
dti-1305	414	1	phenothiazine	phenothiazine	NOUN
dti-1305	414	2	inhibitors	inhibitor	NOUN
dti-1305	414	3	of	of	ADP
dti-1305	414	4	trypanothione	trypanothione	NOUN
dti-1305	414	5	reductase	reductase	NOUN
dti-1305	414	6	as	as	ADP
dti-1305	414	7	potential	potential	ADJ
dti-1305	414	8	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	414	9	and	and	CCONJ
dti-1305	414	10	antileishmanial	antileishmanial	ADJ
dti-1305	414	11	drugs	drug	NOUN
dti-1305	414	12	.	.	PUNCT
dti-1305	415	1	j.	j.	PROPN
dti-1305	415	2	med	med	PROPN
dti-1305	415	3	.	.	PROPN
dti-1305	415	4	chem	chem	PROPN
dti-1305	415	5	.	.	PUNCT
dti-1305	415	6	,	,	PUNCT
dti-1305	415	7	41:148–56	41:148–56	PROPN
dti-1305	415	8	.	.	PUNCT
dti-1305	416	1	chan	chan	PROPN
dti-1305	416	2	,	,	PUNCT
dti-1305	416	3	c.	c.	PROPN
dti-1305	416	4	,	,	PUNCT
dti-1305	416	5	yin	yin	PROPN
dti-1305	416	6	,	,	PUNCT
dti-1305	416	7	h.	h.	PROPN
dti-1305	416	8	,	,	PUNCT
dti-1305	416	9	mckie	mckie	PROPN
dti-1305	416	10	,	,	PUNCT
dti-1305	416	11	j.h	j.h	PROPN
dti-1305	416	12	.	.	PROPN
dti-1305	416	13	et	et	PROPN
dti-1305	416	14	al	al	PROPN
dti-1305	416	15	.	.	PROPN
dti-1305	416	16	2002	2002	NUM
dti-1305	416	17	.	.	PUNCT
dti-1305	417	1	peptoid	peptoid	ADJ
dti-1305	417	2	inhibition	inhibition	NOUN
dti-1305	417	3	of	of	ADP
dti-1305	417	4	trypanothione	trypanothione	NOUN
dti-1305	417	5	reductase	reductase	NOUN
dti-1305	417	6	as	as	ADP
dti-1305	417	7	a	a	DET
dti-1305	417	8	potential	potential	ADJ
dti-1305	417	9	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	417	10	and	and	CCONJ
dti-1305	417	11	antileishmanial	antileishmanial	ADJ
dti-1305	417	12	drug	drug	NOUN
dti-1305	417	13	lead	lead	NOUN
dti-1305	417	14	.	.	PUNCT
dti-1305	418	1	amino	amino	ADJ
dti-1305	418	2	acids	acid	NOUN
dti-1305	418	3	,	,	PUNCT
dti-1305	418	4	22:297–308	22:297–308	NUM
dti-1305	418	5	.	.	PUNCT
dti-1305	418	6	chibale	chibale	PROPN
dti-1305	418	7	,	,	PUNCT
dti-1305	418	8	k.	k.	PROPN
dti-1305	418	9	,	,	PUNCT
dti-1305	418	10	haupt	haupt	PROPN
dti-1305	418	11	,	,	PUNCT
dti-1305	418	12	h.	h.	PROPN
dti-1305	418	13	,	,	PUNCT
dti-1305	418	14	kendrick	kendrick	PROPN
dti-1305	418	15	,	,	PUNCT
dti-1305	418	16	h.	h.	PROPN
dti-1305	418	17	et	et	PROPN
dti-1305	418	18	al	al	PROPN
dti-1305	418	19	.	.	PROPN
dti-1305	418	20	2001	2001	NUM
dti-1305	418	21	.	.	PUNCT
dti-1305	419	1	antiprotozoal	antiprotozoal	NOUN
dti-1305	419	2	and	and	CCONJ
dti-1305	419	3	cytotoxicity	cytotoxicity	NOUN
dti-1305	419	4	evaluation	evaluation	NOUN
dti-1305	419	5	of	of	ADP
dti-1305	419	6	sulfonamide	sulfonamide	NOUN
dti-1305	419	7	and	and	CCONJ
dti-1305	419	8	urea	urea	NOUN
dti-1305	419	9	analogues	analogue	NOUN
dti-1305	419	10	of	of	ADP
dti-1305	419	11	quinacrine	quinacrine	NOUN
dti-1305	419	12	.	.	PUNCT
dti-1305	420	1	bioorg	bioorg	PROPN
dti-1305	420	2	.	.	PUNCT
dti-1305	421	1	med	med	PROPN
dti-1305	421	2	.	.	PROPN
dti-1305	421	3	chem	chem	PROPN
dti-1305	421	4	.	.	PUNCT
dti-1305	422	1	lett	lett	PROPN
dti-1305	422	2	,	,	PUNCT
dti-1305	422	3	11:2655–7	11:2655–7	NUM
dti-1305	422	4	.	.	PUNCT
dti-1305	423	1	chibale	chibale	PROPN
dti-1305	423	2	,	,	PUNCT
dti-1305	423	3	k.	k.	PROPN
dti-1305	423	4	,	,	PUNCT
dti-1305	423	5	visser	visser	PROPN
dti-1305	423	6	,	,	PUNCT
dti-1305	423	7	m.	m.	NOUN
dti-1305	423	8	,	,	PUNCT
dti-1305	423	9	van	van	PROPN
dti-1305	423	10	schalkwyk	schalkwyk	PROPN
dti-1305	423	11	,	,	PUNCT
dti-1305	423	12	d.	d.	PROPN
dti-1305	423	13	et	et	PROPN
dti-1305	423	14	al	al	PROPN
dti-1305	423	15	.	.	PROPN
dti-1305	423	16	2003	2003	NUM
dti-1305	423	17	.	.	PUNCT
dti-1305	424	1	exploring	explore	VERB
dti-1305	424	2	the	the	DET
dti-1305	424	3	potential	potential	NOUN
dti-1305	424	4	of	of	ADP
dti-1305	424	5	xanthene	xanthene	ADJ
dti-1305	424	6	derivatives	derivative	NOUN
dti-1305	424	7	as	as	ADP
dti-1305	424	8	trypanothione	trypanothione	NOUN
dti-1305	424	9	reductase	reductase	NOUN
dti-1305	424	10	inhibitors	inhibitor	NOUN
dti-1305	424	11	and	and	CCONJ
dti-1305	424	12	chloroquine	chloroquine	NOUN
dti-1305	424	13	potentiating	potentiate	VERB
dti-1305	424	14	agents	agent	NOUN
dti-1305	424	15	.	.	PUNCT
dti-1305	425	1	tetrahedron	tetrahedron	NOUN
dti-1305	425	2	,	,	PUNCT
dti-1305	425	3	59:2289–96	59:2289–96	NUM
dti-1305	425	4	.	.	PUNCT
dti-1305	426	1	clarkson	clarkson	PROPN
dti-1305	426	2	,	,	PUNCT
dti-1305	426	3	abjr	abjr	NOUN
dti-1305	426	4	,	,	PUNCT
dti-1305	426	5	brohn	brohn	ADJ
dti-1305	426	6	.	.	PUNCT
dti-1305	426	7	,	,	PUNCT
dti-1305	426	8	f.h	f.h	PROPN
dti-1305	426	9	.	.	PROPN
dti-1305	426	10	,	,	PUNCT
dti-1305	426	11	1976	1976	NUM
dti-1305	426	12	.	.	PUNCT
dti-1305	427	1	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	427	2	:	:	PUNCT
dti-1305	427	3	an	an	DET
dti-1305	427	4	approach	approach	NOUN
dti-1305	427	5	to	to	ADP
dti-1305	427	6	chemotherapy	chemotherapy	NOUN
dti-1305	427	7	by	by	ADP
dti-1305	427	8	the	the	DET
dti-1305	427	9	inhibition	inhibition	NOUN
dti-1305	427	10	of	of	ADP
dti-1305	427	11	carbohydrate	carbohydrate	ADJ
dti-1305	427	12	catabolism	catabolism	NOUN
dti-1305	427	13	.	.	PUNCT
dti-1305	428	1	science	science	NOUN
dti-1305	428	2	,	,	PUNCT
dti-1305	428	3	194(4261):204–6	194(4261):204–6	PROPN
dti-1305	428	4	.	.	PUNCT
dti-1305	429	1	croft	croft	PROPN
dti-1305	429	2	,	,	PUNCT
dti-1305	429	3	s.l	s.l	PROPN
dti-1305	429	4	.	.	PROPN
dti-1305	429	5	,	,	PUNCT
dti-1305	429	6	1988	1988	NUM
dti-1305	429	7	.	.	PUNCT
dti-1305	430	1	recent	recent	ADJ
dti-1305	430	2	developments	development	NOUN
dti-1305	430	3	in	in	ADP
dti-1305	430	4	the	the	DET
dti-1305	430	5	chemotherapy	chemotherapy	NOUN
dti-1305	430	6	of	of	ADP
dti-1305	430	7	leishmaniasis	leishmaniasis	NOUN
dti-1305	430	8	.	.	PUNCT
dti-1305	431	1	trends	trend	NOUN
dti-1305	431	2	.	.	PUNCT
dti-1305	432	1	pharmacol	pharmacol	PROPN
dti-1305	432	2	.	.	PUNCT
dti-1305	433	1	sci	sci	PROPN
dti-1305	433	2	.	.	PROPN
dti-1305	434	1	,	,	PUNCT
dti-1305	435	1	9:376–81	9:376–81	NUM
dti-1305	435	2	.	.	PUNCT
dti-1305	435	3	crout	crout	PROPN
dti-1305	435	4	,	,	PUNCT
dti-1305	435	5	j.r	j.r	PROPN
dti-1305	435	6	.	.	PROPN
dti-1305	435	7	,	,	PUNCT
dti-1305	435	8	1989	1989	NUM
dti-1305	435	9	.	.	PUNCT
dti-1305	436	1	enzymes	enzyme	NOUN
dti-1305	436	2	as	as	ADP
dti-1305	436	3	targets	target	NOUN
dti-1305	436	4	for	for	ADP
dti-1305	436	5	drug	drug	NOUN
dti-1305	436	6	design	design	NOUN
dti-1305	436	7	.	.	PUNCT
dti-1305	437	1	in	in	ADP
dti-1305	437	2	palfreyman	palfreyman	NOUN
dti-1305	437	3	,	,	PUNCT
dti-1305	437	4	mccann	mccann	PROPN
dti-1305	437	5	lovenberg	lovenberg	PROPN
dti-1305	437	6	,	,	PUNCT
dti-1305	437	7	et	et	PROPN
dti-1305	437	8	al	al	PROPN
dti-1305	437	9	.	.	PUNCT
dti-1305	438	1	ed	ed	PROPN
dti-1305	438	2	.	.	PUNCT
dti-1305	439	1	london	london	PROPN
dti-1305	439	2	:	:	PUNCT
dti-1305	439	3	academic	academic	ADJ
dti-1305	439	4	press	press	NOUN
dti-1305	439	5	.	.	PUNCT
dti-1305	440	1	de	de	X
dti-1305	440	2	luca	luca	PROPN
dti-1305	440	3	,	,	PUNCT
dti-1305	440	4	s.	s.	PROPN
dti-1305	440	5	,	,	PUNCT
dti-1305	440	6	ulhaq	ulhaq	PROPN
dti-1305	440	7	,	,	PUNCT
dti-1305	440	8	s.	s.	PROPN
dti-1305	440	9	,	,	PUNCT
dti-1305	440	10	dixon	dixon	PROPN
dti-1305	440	11	,	,	PUNCT
dti-1305	440	12	m.j	m.j	PROPN
dti-1305	440	13	.	.	PROPN
dti-1305	440	14	et	et	PROPN
dti-1305	440	15	al	al	PROPN
dti-1305	440	16	.	.	PROPN
dti-1305	440	17	2003	2003	NUM
dti-1305	440	18	.	.	PUNCT
dti-1305	440	19	solid	solid	ADJ
dti-1305	440	20	phase	phase	NOUN
dti-1305	440	21	synthesis	synthesis	NOUN
dti-1305	440	22	of	of	ADP
dti-1305	440	23	focused	focused	ADJ
dti-1305	440	24	library	library	NOUN
dti-1305	440	25	of	of	ADP
dti-1305	440	26	trypanothione	trypanothione	NOUN
dti-1305	440	27	reductase	reductase	NOUN
dti-1305	440	28	inhibitors	inhibitor	NOUN
dti-1305	440	29	.	.	PUNCT
dti-1305	441	1	tet	tet	NOUN
dti-1305	441	2	lett	lett	PROPN
dti-1305	441	3	,	,	PUNCT
dti-1305	441	4	44:3195–7	44:3195–7	NUM
dti-1305	441	5	.	.	PUNCT
dti-1305	442	1	docampo	docampo	PROPN
dti-1305	442	2	,	,	PUNCT
dti-1305	442	3	r.	r.	PROPN
dti-1305	442	4	and	and	CCONJ
dti-1305	442	5	stoppani	stoppani	NOUN
dti-1305	442	6	,	,	PUNCT
dti-1305	442	7	a.o.m	a.o.m	NOUN
dti-1305	442	8	.	.	PUNCT
dti-1305	442	9	,	,	PUNCT
dti-1305	442	10	1979	1979	NUM
dti-1305	442	11	.	.	PUNCT
dti-1305	443	1	generation	generation	NOUN
dti-1305	443	2	of	of	ADP
dti-1305	443	3	superoxide	superoxide	NOUN
dti-1305	443	4	anion	anion	NOUN
dti-1305	443	5	and	and	CCONJ
dti-1305	443	6	hydrogen	hydrogen	NOUN
dti-1305	443	7	peroxide	peroxide	NOUN
dti-1305	443	8	induced	induce	VERB
dti-1305	443	9	by	by	ADP
dti-1305	443	10	nifurtimox	nifurtimox	PROPN
dti-1305	443	11	in	in	ADP
dti-1305	443	12	trypanosoma	trypanosoma	PROPN
dti-1305	443	13	cruzi	cruzi	PROPN
dti-1305	443	14	.	.	PUNCT
dti-1305	444	1	arch	arch	PROPN
dti-1305	444	2	.	.	PUNCT
dti-1305	445	1	biochem	biochem	PROPN
dti-1305	445	2	.	.	PUNCT
dti-1305	446	1	biophys	biophy	NOUN
dti-1305	446	2	.	.	PUNCT
dti-1305	447	1	,	,	PUNCT
dti-1305	447	2	197:317–21	197:317–21	NUM
dti-1305	447	3	.	.	PUNCT
dti-1305	448	1	docampo	docampo	PROPN
dti-1305	448	2	,	,	PUNCT
dti-1305	448	3	r.	r.	PROPN
dti-1305	448	4	and	and	CCONJ
dti-1305	448	5	moreno	moreno	PROPN
dti-1305	448	6	,	,	PUNCT
dti-1305	448	7	s.n.j	s.n.j	NOUN
dti-1305	448	8	.	.	NOUN
dti-1305	448	9	,	,	PUNCT
dti-1305	448	10	1984a	1984a	NUM
dti-1305	448	11	.	.	PUNCT
dti-1305	449	1	free	free	ADJ
dti-1305	449	2	-	-	PUNCT
dti-1305	449	3	radical	radical	ADJ
dti-1305	449	4	intermediates	intermediate	NOUN
dti-1305	449	5	in	in	ADP
dti-1305	449	6	the	the	DET
dti-1305	449	7	antiparasitic	antiparasitic	ADJ
dti-1305	449	8	action	action	NOUN
dti-1305	449	9	of	of	ADP
dti-1305	449	10	drugs	drug	NOUN
dti-1305	449	11	and	and	CCONJ
dti-1305	449	12	phagocytic	phagocytic	ADJ
dti-1305	449	13	cells	cell	NOUN
dti-1305	449	14	.	.	PUNCT
dti-1305	450	1	free	free	ADJ
dti-1305	450	2	radicals	radical	NOUN
dti-1305	450	3	.	.	PUNCT
dti-1305	451	1	biol	biol	PROPN
dti-1305	451	2	.	.	PUNCT
dti-1305	451	3	,	,	PUNCT
dti-1305	452	1	6:243–88	6:243–88	X
dti-1305	452	2	.	.	PUNCT
dti-1305	453	1	docampo	docampo	PROPN
dti-1305	453	2	,	,	PUNCT
dti-1305	453	3	r.	r.	PROPN
dti-1305	453	4	and	and	CCONJ
dti-1305	453	5	moreno	moreno	PROPN
dti-1305	453	6	,	,	PUNCT
dti-1305	453	7	s.n.j	s.n.j	NOUN
dti-1305	453	8	.	.	PUNCT
dti-1305	453	9	,	,	PUNCT
dti-1305	453	10	1984b	1984b	NUM
dti-1305	453	11	.	.	PUNCT
dti-1305	454	1	free	free	ADJ
dti-1305	454	2	radical	radical	ADJ
dti-1305	454	3	metabolites	metabolite	NOUN
dti-1305	454	4	in	in	ADP
dti-1305	454	5	the	the	DET
dti-1305	454	6	mode	mode	NOUN
dti-1305	454	7	of	of	ADP
dti-1305	454	8	action	action	NOUN
dti-1305	454	9	of	of	ADP
dti-1305	454	10	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	454	11	agents	agent	NOUN
dti-1305	454	12	and	and	CCONJ
dti-1305	454	13	phagocytic	phagocytic	ADJ
dti-1305	454	14	cells	cell	NOUN
dti-1305	454	15	on	on	ADP
dti-1305	454	16	trypanosoma	trypanosoma	PROPN
dti-1305	454	17	cruzi	cruzi	PROPN
dti-1305	454	18	.	.	PUNCT
dti-1305	455	1	rev	rev	PROPN
dti-1305	455	2	.	.	PROPN
dti-1305	455	3	infect	infect	VERB
dti-1305	455	4	.	.	PUNCT
dti-1305	456	1	dis	dis	PROPN
dti-1305	456	2	.	.	PUNCT
dti-1305	456	3	,	,	PUNCT
dti-1305	456	4	6:223–38	6:223–38	PROPN
dti-1305	456	5	.	.	PUNCT
dti-1305	456	6	docampo	docampo	PROPN
dti-1305	456	7	,	,	PUNCT
dti-1305	456	8	r.	r.	PROPN
dti-1305	456	9	and	and	CCONJ
dti-1305	456	10	moreno	moreno	PROPN
dti-1305	456	11	,	,	PUNCT
dti-1305	456	12	s.n.j	s.n.j	NOUN
dti-1305	456	13	.	.	PROPN
dti-1305	456	14	,	,	PUNCT
dti-1305	456	15	1986	1986	NUM
dti-1305	456	16	.	.	PUNCT
dti-1305	457	1	free	free	ADJ
dti-1305	457	2	radical	radical	ADJ
dti-1305	457	3	metabolism	metabolism	NOUN
dti-1305	457	4	of	of	ADP
dti-1305	457	5	antiparasitic	antiparasitic	ADJ
dti-1305	457	6	agents	agent	NOUN
dti-1305	457	7	.	.	PUNCT
dti-1305	458	1	fed	fed	PROPN
dti-1305	458	2	.	.	PUNCT
dti-1305	459	1	proc	proc	PROPN
dti-1305	459	2	.	.	PROPN
dti-1305	459	3	,	,	PUNCT
dti-1305	459	4	45:2471–6	45:2471–6	NUM
dti-1305	459	5	.	.	PUNCT
dti-1305	460	1	donelson	donelson	PROPN
dti-1305	460	2	,	,	PUNCT
dti-1305	460	3	j.e	j.e	PROPN
dti-1305	460	4	.	.	PROPN
dti-1305	460	5	and	and	CCONJ
dti-1305	460	6	rice	rice	NOUN
dti-1305	460	7	-	-	PUNCT
dti-1305	460	8	ficht	ficht	NOUN
dti-1305	460	9	,	,	PUNCT
dti-1305	460	10	a.c	a.c	PROPN
dti-1305	460	11	.	.	PROPN
dti-1305	460	12	,	,	PUNCT
dti-1305	460	13	1985	1985	NUM
dti-1305	460	14	.	.	PUNCT
dti-1305	461	1	molecular	molecular	ADJ
dti-1305	461	2	biology	biology	NOUN
dti-1305	461	3	of	of	ADP
dti-1305	461	4	trypanosome	trypanosome	NOUN
dti-1305	461	5	antigenic	antigenic	ADJ
dti-1305	461	6	variation	variation	NOUN
dti-1305	461	7	.	.	PUNCT
dti-1305	462	1	microbiol	microbiol	PROPN
dti-1305	462	2	.	.	PUNCT
dti-1305	463	1	rev	rev	PROPN
dti-1305	463	2	.	.	PROPN
dti-1305	463	3	,	,	PUNCT
dti-1305	463	4	49:107–25	49:107–25	PROPN
dti-1305	463	5	.	.	PUNCT
dti-1305	464	1	dumas	dumas	PROPN
dti-1305	464	2	,	,	PUNCT
dti-1305	464	3	c.	c.	PROPN
dti-1305	464	4	,	,	PUNCT
dti-1305	464	5	ouellette	ouellette	PROPN
dti-1305	464	6	,	,	PUNCT
dti-1305	464	7	m.	m.	NOUN
dti-1305	464	8	,	,	PUNCT
dti-1305	464	9	tovar	tovar	PROPN
dti-1305	464	10	,	,	PUNCT
dti-1305	464	11	j.	j.	PROPN
dti-1305	464	12	et	et	PROPN
dti-1305	464	13	al	al	PROPN
dti-1305	464	14	.	.	PROPN
dti-1305	464	15	1997	1997	NUM
dti-1305	464	16	.	.	PUNCT
dti-1305	465	1	disruption	disruption	NOUN
dti-1305	465	2	of	of	ADP
dti-1305	465	3	the	the	DET
dti-1305	465	4	trypanothione	trypanothione	NOUN
dti-1305	465	5	reductase	reductase	NOUN
dti-1305	465	6	gene	gene	NOUN
dti-1305	465	7	of	of	ADP
dti-1305	465	8	leishmania	leishmania	NOUN
dti-1305	465	9	decreases	decrease	VERB
dti-1305	465	10	its	its	PRON
dti-1305	465	11	ability	ability	NOUN
dti-1305	465	12	to	to	PART
dti-1305	465	13	survive	survive	VERB
dti-1305	465	14	oxidative	oxidative	ADJ
dti-1305	465	15	stress	stress	NOUN
dti-1305	465	16	in	in	ADP
dti-1305	465	17	macrophages	macrophage	NOUN
dti-1305	465	18	.	.	PUNCT
dti-1305	466	1	embo	embo	NOUN
dti-1305	466	2	,	,	PUNCT
dti-1305	466	3	j.	j.	PROPN
dti-1305	466	4	,	,	PUNCT
dti-1305	466	5	16:2590–8	16:2590–8	NUM
dti-1305	466	6	.	.	PUNCT
dti-1305	467	1	el	el	PROPN
dti-1305	467	2	kouni	kouni	PROPN
dti-1305	467	3	,	,	PUNCT
dti-1305	467	4	m.h	m.h	PROPN
dti-1305	467	5	.	.	PROPN
dti-1305	467	6	,	,	PUNCT
dti-1305	467	7	2003	2003	NUM
dti-1305	467	8	.	.	PUNCT
dti-1305	468	1	potential	potential	ADJ
dti-1305	468	2	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	468	3	targets	target	NOUN
dti-1305	468	4	in	in	ADP
dti-1305	468	5	the	the	DET
dti-1305	468	6	purine	purine	NOUN
dti-1305	468	7	metabolism	metabolism	NOUN
dti-1305	468	8	of	of	ADP
dti-1305	468	9	parasites	parasite	NOUN
dti-1305	468	10	.	.	PUNCT
dti-1305	469	1	pharmacol	pharmacol	PROPN
dti-1305	469	2	.	.	PUNCT
dti-1305	470	1	therapeut	therapeut	PROPN
dti-1305	470	2	.	.	PUNCT
dti-1305	470	3	,	,	PUNCT
dti-1305	471	1	99:283–309	99:283–309	PROPN
dti-1305	471	2	.	.	PUNCT
dti-1305	472	1	el	el	PROPN
dti-1305	472	2	-	-	PUNCT
dti-1305	472	3	waer	waer	PROPN
dti-1305	472	4	,	,	PUNCT
dti-1305	472	5	a.	a.	PROPN
dti-1305	472	6	,	,	PUNCT
dti-1305	472	7	douglas	douglas	PROPN
dti-1305	472	8	,	,	PUNCT
dti-1305	472	9	k.t	k.t	PROPN
dti-1305	472	10	.	.	PROPN
dti-1305	472	11	,	,	PUNCT
dti-1305	472	12	smith	smith	PROPN
dti-1305	472	13	,	,	PUNCT
dti-1305	472	14	k.	k.	PROPN
dti-1305	472	15	et	et	PROPN
dti-1305	472	16	al	al	PROPN
dti-1305	472	17	.	.	PROPN
dti-1305	472	18	1991	1991	NUM
dti-1305	472	19	.	.	PUNCT
dti-1305	473	1	synthesis	synthesis	NOUN
dti-1305	473	2	of	of	ADP
dti-1305	473	3	n	n	CCONJ
dti-1305	473	4	-	-	PUNCT
dti-1305	473	5	benzyloxycarbonyl	benzyloxycarbonyl	NOUN
dti-1305	473	6	-	-	PUNCT
dti-1305	473	7	l	l	NOUN
dti-1305	473	8	-	-	NOUN
dti-1305	473	9	cysteinylglycine	cysteinylglycine	ADJ
dti-1305	473	10	3	3	NUM
dti-1305	473	11	-	-	PUNCT
dti-1305	473	12	dimethylaminopropylamide	dimethylaminopropylamide	NOUN
dti-1305	473	13	disulfide	disulfide	NOUN
dti-1305	473	14	:	:	PUNCT
dti-1305	473	15	a	a	DET
dti-1305	473	16	cheap	cheap	ADJ
dti-1305	473	17	and	and	CCONJ
dti-1305	473	18	convenient	convenient	ADJ
dti-1305	473	19	new	new	ADJ
dti-1305	473	20	assay	assay	NOUN
dti-1305	473	21	for	for	ADP
dti-1305	473	22	trypanothione	trypanothione	NOUN
dti-1305	473	23	reductase	reductase	NOUN
dti-1305	473	24	.	.	PUNCT
dti-1305	474	1	anal	anal	PROPN
dti-1305	474	2	.	.	PUNCT
dti-1305	474	3	biochem	biochem	PROPN
dti-1305	474	4	.	.	PUNCT
dti-1305	474	5	,	,	PUNCT
dti-1305	475	1	198:212–16	198:212–16	NUM
dti-1305	475	2	.	.	PUNCT
dti-1305	476	1	el	el	PROPN
dti-1305	476	2	-	-	PUNCT
dti-1305	476	3	waer	waer	PROPN
dti-1305	476	4	,	,	PUNCT
dti-1305	476	5	a.f	a.f	PROPN
dti-1305	476	6	.	.	PROPN
dti-1305	476	7	,	,	PUNCT
dti-1305	476	8	smith	smith	PROPN
dti-1305	476	9	,	,	PUNCT
dti-1305	476	10	k.	k.	PROPN
dti-1305	476	11	,	,	PUNCT
dti-1305	476	12	mckie	mckie	PROPN
dti-1305	476	13	,	,	PUNCT
dti-1305	476	14	j.h	j.h	PROPN
dti-1305	476	15	.	.	PROPN
dti-1305	476	16	et	et	PROPN
dti-1305	476	17	al	al	PROPN
dti-1305	476	18	.	.	PROPN
dti-1305	476	19	1993a	1993a	NUM
dti-1305	476	20	.	.	PUNCT
dti-1305	477	1	the	the	DET
dti-1305	477	2	glutamyl	glutamyl	NOUN
dti-1305	477	3	binding	bind	VERB
dti-1305	477	4	site	site	NOUN
dti-1305	477	5	of	of	ADP
dti-1305	477	6	trypanothione	trypanothione	PROPN
dti-1305	477	7	reductase	reductase	NOUN
dti-1305	477	8	from	from	ADP
dti-1305	477	9	crithidia	crithidia	NOUN
dti-1305	477	10	fasciculata	fasciculata	NOUN
dti-1305	477	11	:	:	PUNCT
dti-1305	477	12	enzyme	enzyme	NOUN
dti-1305	477	13	kinetic	kinetic	ADJ
dti-1305	477	14	properties	property	NOUN
dti-1305	477	15	of	of	ADP
dti-1305	477	16	γ	γ	PROPN
dti-1305	477	17	-	-	PUNCT
dti-1305	477	18	glutamyl	glutamyl	NOUN
dti-1305	477	19	-	-	PUNCT
dti-1305	477	20	modifi	modifi	NOUN
dti-1305	477	21	ed	ed	NOUN
dti-1305	477	22	substrate	substrate	NOUN
dti-1305	477	23	analogs	analog	NOUN
dti-1305	477	24	.	.	PUNCT
dti-1305	478	1	biochim	biochim	NOUN
dti-1305	478	2	.	.	PUNCT
dti-1305	479	1	biophys	biophy	NOUN
dti-1305	479	2	,	,	PUNCT
dti-1305	479	3	acta	acta	PROPN
dti-1305	479	4	,	,	PUNCT
dti-1305	479	5	prot	prot	NOUN
dti-1305	479	6	.	.	PUNCT
dti-1305	480	1	struc	struc	PROPN
dti-1305	480	2	.	.	PUNCT
dti-1305	481	1	mol	mol	PROPN
dti-1305	481	2	.	.	PROPN
dti-1305	481	3	enzymol	enzymol	PROPN
dti-1305	481	4	.	.	PROPN
dti-1305	482	1	,	,	PUNCT
dti-1305	483	1	1203:93–8	1203:93–8	NUM
dti-1305	483	2	.	.	PUNCT
dti-1305	484	1	el	el	PROPN
dti-1305	484	2	-	-	PUNCT
dti-1305	484	3	waer	waer	PROPN
dti-1305	484	4	,	,	PUNCT
dti-1305	484	5	a.f	a.f	PROPN
dti-1305	484	6	.	.	PROPN
dti-1305	484	7	,	,	PUNCT
dti-1305	484	8	benson	benson	PROPN
dti-1305	484	9	,	,	PUNCT
dti-1305	484	10	t.	t.	PROPN
dti-1305	484	11	,	,	PUNCT
dti-1305	484	12	douglas	douglas	PROPN
dti-1305	484	13	.	.	PUNCT
dti-1305	485	1	k.t	k.t	PROPN
dti-1305	485	2	.	.	PROPN
dti-1305	485	3	,	,	PUNCT
dti-1305	485	4	1993b	1993b	NUM
dti-1305	485	5	.	.	PUNCT
dti-1305	486	1	synthesis	synthesis	NOUN
dti-1305	486	2	of	of	ADP
dti-1305	486	3	substrate	substrate	NOUN
dti-1305	486	4	analogs	analog	NOUN
dti-1305	486	5	for	for	ADP
dti-1305	486	6	trypanothione	trypanothione	NOUN
dti-1305	486	7	reductase	reductase	NOUN
dti-1305	486	8	.	.	PUNCT
dti-1305	487	1	int	int	NOUN
dti-1305	487	2	.	.	PUNCT
dti-1305	488	1	j.	j.	PROPN
dti-1305	488	2	pept	pept	PROPN
dti-1305	488	3	.	.	PUNCT
dti-1305	489	1	prot	prot	PROPN
dti-1305	489	2	.	.	PUNCT
dti-1305	490	1	res	re	NOUN
dti-1305	490	2	.	.	PROPN
dti-1305	490	3	,	,	PUNCT
dti-1305	490	4	41:141–6	41:141–6	NUM
dti-1305	490	5	.	.	PUNCT
dti-1305	491	1	fairlamb	fairlamb	PROPN
dti-1305	491	2	,	,	PUNCT
dti-1305	491	3	a.h	a.h	PROPN
dti-1305	491	4	.	.	PROPN
dti-1305	491	5	,	,	PUNCT
dti-1305	491	6	bowman	bowman	PROPN
dti-1305	491	7	,	,	PUNCT
dti-1305	491	8	i.b.r	i.b.r	PROPN
dti-1305	491	9	.	.	PROPN
dti-1305	491	10	,	,	PUNCT
dti-1305	491	11	1980	1980	NUM
dti-1305	491	12	.	.	PUNCT
dti-1305	492	1	trypanosoma	trypanosoma	PROPN
dti-1305	492	2	brucei	brucei	PROPN
dti-1305	492	3	:	:	PUNCT
dti-1305	492	4	maintenance	maintenance	NOUN
dti-1305	492	5	of	of	ADP
dti-1305	492	6	concentrated	concentrated	ADJ
dti-1305	492	7	suspensions	suspension	NOUN
dti-1305	492	8	of	of	ADP
dti-1305	492	9	bloodstream	bloodstream	NOUN
dti-1305	492	10	trypomastigotes	trypomastigote	NOUN
dti-1305	492	11	in	in	ADP
dti-1305	492	12	vitro	vitro	X
dti-1305	492	13	using	use	VERB
dti-1305	492	14	continuous	continuous	ADJ
dti-1305	492	15	dialysis	dialysis	NOUN
dti-1305	492	16	for	for	ADP
dti-1305	492	17	measurement	measurement	NOUN
dti-1305	492	18	of	of	ADP
dti-1305	492	19	endocytosis	endocytosis	NOUN
dti-1305	492	20	.	.	PUNCT
dti-1305	493	1	exp	exp	NOUN
dti-1305	493	2	parasitol	parasitol	NOUN
dti-1305	493	3	,	,	PUNCT
dti-1305	493	4	49:366–80	49:366–80	PROPN
dti-1305	493	5	.	.	PUNCT
dti-1305	494	1	fairlamb	fairlamb	PROPN
dti-1305	494	2	,	,	PUNCT
dti-1305	494	3	a.h	a.h	PROPN
dti-1305	494	4	.	.	PROPN
dti-1305	494	5	,	,	PUNCT
dti-1305	494	6	blackburn	blackburn	PROPN
dti-1305	494	7	,	,	PUNCT
dti-1305	494	8	p.	p.	PROPN
dti-1305	494	9	,	,	PUNCT
dti-1305	494	10	ulrich	ulrich	PROPN
dti-1305	494	11	,	,	PUNCT
dti-1305	494	12	p.	p.	NOUN
dti-1305	494	13	et	et	NOUN
dti-1305	495	1	al	al	PROPN
dti-1305	495	2	.	.	PROPN
dti-1305	495	3	1985	1985	NUM
dti-1305	495	4	.	.	PUNCT
dti-1305	496	1	trypanothione	trypanothione	NOUN
dti-1305	496	2	:	:	PUNCT
dti-1305	496	3	a	a	DET
dti-1305	496	4	novel	novel	ADJ
dti-1305	496	5	bis(glutathionyl)spermidine	bis(glutathionyl)spermidine	NUM
dti-1305	496	6	cofactor	cofactor	NOUN
dti-1305	496	7	for	for	ADP
dti-1305	496	8	glutathione	glutathione	NOUN
dti-1305	496	9	reductase	reductase	NOUN
dti-1305	496	10	in	in	ADP
dti-1305	496	11	trypanosomatids	trypanosomatids	PROPN
dti-1305	496	12	.	.	PUNCT
dti-1305	497	1	science	science	NOUN
dti-1305	497	2	,	,	PUNCT
dti-1305	497	3	227(4693):1485–7	227(4693):1485–7	NUM
dti-1305	497	4	.	.	PUNCT
dti-1305	498	1	fairlamb	fairlamb	PROPN
dti-1305	498	2	,	,	PUNCT
dti-1305	498	3	a.h	a.h	PROPN
dti-1305	498	4	.	.	PROPN
dti-1305	498	5	,	,	PUNCT
dti-1305	498	6	cerami	cerami	PROPN
dti-1305	498	7	,	,	PUNCT
dti-1305	498	8	a.	a.	NOUN
dti-1305	498	9	,	,	PUNCT
dti-1305	498	10	1992	1992	NUM
dti-1305	498	11	.	.	PUNCT
dti-1305	499	1	metabolism	metabolism	NOUN
dti-1305	499	2	and	and	CCONJ
dti-1305	499	3	functions	function	NOUN
dti-1305	499	4	of	of	ADP
dti-1305	499	5	trypanothione	trypanothione	NOUN
dti-1305	499	6	in	in	ADP
dti-1305	499	7	the	the	DET
dti-1305	499	8	kinetoplastida	kinetoplastida	PROPN
dti-1305	499	9	.	.	PUNCT
dti-1305	499	10	annu	annu	PROPN
dti-1305	499	11	.	.	PUNCT
dti-1305	500	1	rev	rev	PROPN
dti-1305	500	2	.	.	PROPN
dti-1305	500	3	microbiol	microbiol	PROPN
dti-1305	500	4	.	.	PUNCT
dti-1305	500	5	,	,	PUNCT
dti-1305	501	1	46:695–729	46:695–729	PROPN
dti-1305	501	2	.	.	PUNCT
dti-1305	502	1	fairlamb	fairlamb	PROPN
dti-1305	502	2	,	,	PUNCT
dti-1305	502	3	a.h	a.h	PROPN
dti-1305	502	4	.	.	PROPN
dti-1305	502	5	,	,	PUNCT
dti-1305	502	6	2003a	2003a	NUM
dti-1305	502	7	.	.	PUNCT
dti-1305	503	1	chemotherapy	chemotherapy	NOUN
dti-1305	503	2	of	of	ADP
dti-1305	503	3	human	human	ADJ
dti-1305	503	4	african	african	ADJ
dti-1305	503	5	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	503	6	:	:	PUNCT
dti-1305	503	7	current	current	ADJ
dti-1305	503	8	and	and	CCONJ
dti-1305	503	9	future	future	ADJ
dti-1305	503	10	prospects	prospect	NOUN
dti-1305	503	11	.	.	PUNCT
dti-1305	504	1	trends	trend	NOUN
dti-1305	504	2	in	in	ADP
dti-1305	504	3	parasitology	parasitology	NOUN
dti-1305	504	4	.	.	PUNCT
dti-1305	504	5	,	,	PUNCT
dti-1305	504	6	19(11):488–494	19(11):488–494	X
dti-1305	504	7	.	.	PUNCT
dti-1305	504	8	fairlamb	fairlamb	PROPN
dti-1305	504	9	,	,	PUNCT
dti-1305	504	10	a.h	a.h	PROPN
dti-1305	504	11	.	.	PROPN
dti-1305	504	12	,	,	PUNCT
dti-1305	504	13	2003b	2003b	NUM
dti-1305	504	14	.	.	PUNCT
dti-1305	505	1	target	target	NOUN
dti-1305	505	2	discovery	discovery	NOUN
dti-1305	505	3	and	and	CCONJ
dti-1305	505	4	validation	validation	NOUN
dti-1305	505	5	with	with	ADP
dti-1305	505	6	special	special	ADJ
dti-1305	505	7	reference	reference	NOUN
dti-1305	505	8	to	to	ADP
dti-1305	505	9	trypanothione	trypanothione	PROPN
dti-1305	505	10	.	.	PUNCT
dti-1305	506	1	in	in	ADP
dti-1305	506	2	fairlamb	fairlamb	PROPN
dti-1305	506	3	,	,	PUNCT
dti-1305	506	4	a.h	a.h	PROPN
dti-1305	506	5	.	.	PROPN
dti-1305	506	6	,	,	PUNCT
dti-1305	506	7	ridley	ridley	PROPN
dti-1305	506	8	,	,	PUNCT
dti-1305	506	9	r.g	r.g	PROPN
dti-1305	506	10	.	.	PROPN
dti-1305	506	11	,	,	PUNCT
dti-1305	506	12	vial	vial	ADJ
dti-1305	506	13	,	,	PUNCT
dti-1305	506	14	h.j	h.j	PROPN
dti-1305	506	15	.	.	PROPN
dti-1305	506	16	,	,	PUNCT
dti-1305	506	17	ed	ed	NOUN
dti-1305	506	18	.	.	PUNCT
dti-1305	507	1	drugs	drug	NOUN
dti-1305	507	2	against	against	ADP
dti-1305	507	3	parasitic	parasitic	ADJ
dti-1305	507	4	diseases	disease	NOUN
dti-1305	507	5	:	:	PUNCT
dti-1305	507	6	r&d	r&d	NOUN
dti-1305	507	7	methodologies	methodology	NOUN
dti-1305	507	8	and	and	CCONJ
dti-1305	507	9	issues	issue	NOUN
dti-1305	507	10	.	.	PUNCT
dti-1305	508	1	ed	ed	X
dti-1305	508	2	.	.	PUNCT
dti-1305	509	1	geneva	geneva	PROPN
dti-1305	509	2	:	:	PUNCT
dti-1305	509	3	who	who	PRON
dti-1305	509	4	tdr	tdr	PROPN
dti-1305	509	5	.	.	PROPN
dti-1305	509	6	pp107–18	pp107–18	PROPN
dti-1305	509	7	.	.	PUNCT
dti-1305	510	1	fernandez	fernandez	PROPN
dti-1305	510	2	-	-	PUNCT
dti-1305	510	3	gomez	gomez	PROPN
dti-1305	510	4	,	,	PUNCT
dti-1305	510	5	r.	r.	PROPN
dti-1305	510	6	,	,	PUNCT
dti-1305	510	7	moutiez	moutiez	NOUN
dti-1305	510	8	,	,	PUNCT
dti-1305	510	9	m.	m.	NOUN
dti-1305	510	10	,	,	PUNCT
dti-1305	510	11	aumercier	aumercier	NOUN
dti-1305	510	12	,	,	PUNCT
dti-1305	510	13	m.	m.	NOUN
dti-1305	510	14	et	et	PROPN
dti-1305	510	15	al	al	PROPN
dti-1305	510	16	.	.	PROPN
dti-1305	510	17	1995	1995	NUM
dti-1305	510	18	.	.	PUNCT
dti-1305	511	1	2	2	NUM
dti-1305	511	2	-	-	PUNCT
dti-1305	511	3	amino	amino	NOUN
dti-1305	511	4	diphenylsulfi	diphenylsulfi	NOUN
dti-1305	511	5	des	des	PROPN
dti-1305	511	6	as	as	ADP
dti-1305	511	7	new	new	ADJ
dti-1305	511	8	inhibitors	inhibitor	NOUN
dti-1305	511	9	of	of	ADP
dti-1305	511	10	trypanothione	trypanothione	NOUN
dti-1305	511	11	reductase	reductase	NOUN
dti-1305	511	12	.	.	PUNCT
dti-1305	512	1	int	int	NOUN
dti-1305	512	2	.	.	PUNCT
dti-1305	513	1	j.	j.	PROPN
dti-1305	513	2	antimicrob	antimicrob	PROPN
dti-1305	513	3	.	.	PUNCT
dti-1305	514	1	agents	agent	NOUN
dti-1305	514	2	.	.	PUNCT
dti-1305	514	3	,	,	PUNCT
dti-1305	515	1	6:111–18	6:111–18	NUM
dti-1305	515	2	.	.	NOUN
dti-1305	515	3	flohé	flohé	ADJ
dti-1305	515	4	l	l	NOUN
dti-1305	515	5	,	,	PUNCT
dti-1305	515	6	1989	1989	NUM
dti-1305	515	7	.	.	PUNCT
dti-1305	516	1	glutathione	glutathione	NOUN
dti-1305	516	2	—	—	PUNCT
dti-1305	516	3	chemical	chemical	NOUN
dti-1305	516	4	,	,	PUNCT
dti-1305	516	5	biochemical	biochemical	ADJ
dti-1305	516	6	and	and	CCONJ
dti-1305	516	7	medical	medical	ADJ
dti-1305	516	8	aspects	aspect	NOUN
dti-1305	516	9	.	.	PUNCT
dti-1305	517	1	in	in	ADP
dti-1305	517	2	dolphine	dolphine	PROPN
dti-1305	517	3	d	d	PROPN
dti-1305	517	4	,	,	PUNCT
dti-1305	517	5	poulson	poulson	NOUN
dti-1305	517	6	r	r	NOUN
dti-1305	517	7	and	and	CCONJ
dti-1305	517	8	avramovic	avramovic	PROPN
dti-1305	517	9	o	o	PROPN
dti-1305	517	10	,	,	PUNCT
dti-1305	517	11	ed	ed	NOUN
dti-1305	517	12	.	.	PUNCT
dti-1305	517	13	new	new	PROPN
dti-1305	517	14	york	york	PROPN
dti-1305	517	15	:	:	PUNCT
dti-1305	517	16	wiley	wiley	PROPN
dti-1305	517	17	interscience	interscience	PROPN
dti-1305	517	18	.	.	PUNCT
dti-1305	518	1	flohé	flohé	ADJ
dti-1305	518	2	l	l	NOUN
dti-1305	518	3	,	,	PUNCT
dti-1305	518	4	1998	1998	NUM
dti-1305	518	5	.	.	PUNCT
dti-1305	519	1	the	the	DET
dti-1305	519	2	achilles	achille	NOUN
dti-1305	519	3	’	'	PUNCT
dti-1305	519	4	heel	heel	NOUN
dti-1305	519	5	of	of	ADP
dti-1305	519	6	trypanosomatids	trypanosomatid	NOUN
dti-1305	519	7	:	:	PUNCT
dti-1305	519	8	trypanothione	trypanothione	NOUN
dti-1305	519	9	-	-	PUNCT
dti-1305	519	10	mediated	mediate	VERB
dti-1305	519	11	hydroperoxide	hydroperoxide	ADP
dti-1305	519	12	metabolism	metabolism	NOUN
dti-1305	519	13	.	.	PUNCT
dti-1305	520	1	biofactors	biofactor	NOUN
dti-1305	520	2	,	,	PUNCT
dti-1305	520	3	8:87–91	8:87–91	PROPN
dti-1305	520	4	.	.	PUNCT
dti-1305	520	5	fournet	fournet	PROPN
dti-1305	520	6	,	,	PUNCT
dti-1305	520	7	a.	a.	NOUN
dti-1305	520	8	,	,	PUNCT
dti-1305	520	9	inchausti	inchausti	PROPN
dti-1305	520	10	,	,	PUNCT
dti-1305	520	11	a.	a.	PROPN
dti-1305	520	12	,	,	PUNCT
dti-1305	520	13	yaluff	yaluff	PROPN
dti-1305	520	14	,	,	PUNCT
dti-1305	520	15	g.	g.	PROPN
dti-1305	520	16	et	et	PROPN
dti-1305	520	17	al	al	PROPN
dti-1305	520	18	.	.	PROPN
dti-1305	520	19	1998	1998	NUM
dti-1305	520	20	.	.	PUNCT
dti-1305	521	1	trypanocidal	trypanocidal	ADJ
dti-1305	521	2	bisbenzylisoquinoline	bisbenzylisoquinoline	NOUN
dti-1305	521	3	alkaloids	alkaloid	NOUN
dti-1305	521	4	are	be	AUX
dti-1305	521	5	inhibitors	inhibitor	NOUN
dti-1305	521	6	of	of	ADP
dti-1305	521	7	trypanothione	trypanothione	NOUN
dti-1305	521	8	reductase	reductase	NOUN
dti-1305	521	9	.	.	PUNCT
dti-1305	522	1	j.	j.	PROPN
dti-1305	522	2	enz	enz	PROPN
dti-1305	522	3	inhibit	inhibit	PROPN
dti-1305	522	4	,	,	PUNCT
dti-1305	522	5	13:1–9	13:1–9	NUM
dti-1305	522	6	.	.	PUNCT
dti-1305	522	7	fournet	fournet	PROPN
dti-1305	522	8	,	,	PUNCT
dti-1305	522	9	a.	a.	NOUN
dti-1305	522	10	,	,	PUNCT
dti-1305	522	11	de	de	X
dti-1305	522	12	arias	arias	PROPN
dti-1305	522	13	,	,	PUNCT
dti-1305	522	14	r.a	r.a	PROPN
dti-1305	522	15	.	.	PROPN
dti-1305	522	16	,	,	PUNCT
dti-1305	522	17	ferreira	ferreira	PROPN
dti-1305	522	18	,	,	PUNCT
dti-1305	522	19	m.e	m.e	PROPN
dti-1305	522	20	.	.	PROPN
dti-1305	522	21	et	et	PROPN
dti-1305	522	22	al	al	PROPN
dti-1305	522	23	.	.	PROPN
dti-1305	522	24	2000	2000	NUM
dti-1305	522	25	.	.	PUNCT
dti-1305	523	1	effi	effi	PROPN
dti-1305	523	2	cacy	cacy	PROPN
dti-1305	523	3	of	of	ADP
dti-1305	523	4	bisbenzylisoquinoline	bisbenzylisoquinoline	NOUN
dti-1305	523	5	alkaloids	alkaloid	NOUN
dti-1305	523	6	in	in	ADP
dti-1305	523	7	acute	acute	ADJ
dti-1305	523	8	and	and	CCONJ
dti-1305	523	9	chronic	chronic	ADJ
dti-1305	523	10	trypanosoma	trypanosoma	NOUN
dti-1305	523	11	cruzi	cruzi	PROPN
dti-1305	523	12	murine	murine	PROPN
dti-1305	523	13	model	model	PROPN
dti-1305	523	14	.	.	PUNCT
dti-1305	524	1	int	int	NOUN
dti-1305	524	2	.	.	PUNCT
dti-1305	525	1	j.	j.	PROPN
dti-1305	525	2	antimicrob	antimicrob	PROPN
dti-1305	525	3	.	.	PUNCT
dti-1305	526	1	agents	agent	NOUN
dti-1305	526	2	.	.	PUNCT
dti-1305	526	3	,	,	PUNCT
dti-1305	526	4	13:189–95	13:189–95	NUM
dti-1305	526	5	.	.	PUNCT
dti-1305	527	1	gallwitz	gallwitz	PROPN
dti-1305	527	2	,	,	PUNCT
dti-1305	527	3	h.	h.	PROPN
dti-1305	527	4	,	,	PUNCT
dti-1305	527	5	bonse	bonse	NOUN
dti-1305	527	6	,	,	PUNCT
dti-1305	527	7	s.	s.	PROPN
dti-1305	527	8	,	,	PUNCT
dti-1305	527	9	martinez	martinez	PROPN
dti-1305	527	10	-	-	PUNCT
dti-1305	527	11	cruz	cruz	PROPN
dti-1305	527	12	,	,	PUNCT
dti-1305	527	13	a.	a.	PROPN
dti-1305	527	14	et	et	PROPN
dti-1305	527	15	al	al	PROPN
dti-1305	527	16	.	.	PROPN
dti-1305	527	17	1999	1999	NUM
dti-1305	527	18	.	.	PUNCT
dti-1305	528	1	ajoene	ajoene	PRON
dti-1305	528	2	is	be	AUX
dti-1305	528	3	an	an	DET
dti-1305	528	4	inhibitor	inhibitor	NOUN
dti-1305	528	5	and	and	CCONJ
dti-1305	528	6	subversive	subversive	ADJ
dti-1305	528	7	substrate	substrate	NOUN
dti-1305	528	8	of	of	ADP
dti-1305	528	9	human	human	ADJ
dti-1305	528	10	glutathione	glutathione	NOUN
dti-1305	528	11	reductase	reductase	NOUN
dti-1305	528	12	and	and	CCONJ
dti-1305	528	13	trypanosoma	trypanosoma	PROPN
dti-1305	528	14	cruzi	cruzi	PROPN
dti-1305	528	15	trypanothione	trypanothione	PROPN
dti-1305	528	16	reductase	reductase	NOUN
dti-1305	528	17	:	:	PUNCT
dti-1305	528	18	crystallographic	crystallographic	ADJ
dti-1305	528	19	,	,	PUNCT
dti-1305	528	20	kinetic	kinetic	NOUN
dti-1305	528	21	,	,	PUNCT
dti-1305	528	22	and	and	CCONJ
dti-1305	528	23	spectroscopic	spectroscopic	ADJ
dti-1305	528	24	studies	study	NOUN
dti-1305	528	25	.	.	PUNCT
dti-1305	529	1	j.	j.	PROPN
dti-1305	529	2	med	med	PROPN
dti-1305	529	3	.	.	PROPN
dti-1305	529	4	chem	chem	PROPN
dti-1305	529	5	.	.	PUNCT
dti-1305	529	6	,	,	PUNCT
dti-1305	529	7	42:364–72	42:364–72	PROPN
dti-1305	529	8	.	.	PUNCT
dti-1305	530	1	garforth	garforth	PROPN
dti-1305	530	2	,	,	PUNCT
dti-1305	530	3	j.	j.	PROPN
dti-1305	530	4	,	,	PUNCT
dti-1305	530	5	mckie	mckie	PROPN
dti-1305	530	6	,	,	PUNCT
dti-1305	530	7	j.h	j.h	PROPN
dti-1305	530	8	.	.	PROPN
dti-1305	530	9	,	,	PUNCT
dti-1305	530	10	jaouhari	jaouhari	PROPN
dti-1305	530	11	,	,	PUNCT
dti-1305	530	12	r.	r.	PROPN
dti-1305	530	13	et	et	PROPN
dti-1305	530	14	al	al	PROPN
dti-1305	530	15	.	.	PROPN
dti-1305	530	16	1994	1994	NUM
dti-1305	530	17	.	.	PUNCT
dti-1305	531	1	rational	rational	ADJ
dti-1305	531	2	design	design	NOUN
dti-1305	531	3	of	of	ADP
dti-1305	531	4	peptide	peptide	ADJ
dti-1305	531	5	-based	-based	ADJ
dti-1305	531	6	inhibitors	inhibitor	NOUN
dti-1305	531	7	of	of	ADP
dti-1305	531	8	trypanothione	trypanothione	NOUN
dti-1305	531	9	reductase	reductase	NOUN
dti-1305	531	10	as	as	ADP
dti-1305	531	11	potential	potential	ADJ
dti-1305	531	12	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	531	13	drugs	drug	NOUN
dti-1305	531	14	.	.	PUNCT
dti-1305	532	1	amino	amino	ADJ
dti-1305	532	2	acids	acid	NOUN
dti-1305	532	3	,	,	PUNCT
dti-1305	532	4	6:295–9	6:295–9	NOUN
dti-1305	532	5	.	.	PUNCT
dti-1305	532	6	drug	drug	NOUN
dti-1305	532	7	target	target	NOUN
dti-1305	532	8	insights	insight	NOUN
dti-1305	532	9	2007	2007	NUM
dti-1305	532	10	:	:	PUNCT
dti-1305	532	11	2	2	NUM
dti-1305	532	12	145	145	NUM
dti-1305	532	13	target	target	NOUN
dti-1305	532	14	for	for	ADP
dti-1305	532	15	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	532	16	and	and	CCONJ
dti-1305	532	17	antileishmanial	antileishmanial	ADJ
dti-1305	532	18	drug	drug	NOUN
dti-1305	532	19	design	design	NOUN
dti-1305	532	20	garforth	garforth	NOUN
dti-1305	532	21	,	,	PUNCT
dti-1305	532	22	j.	j.	PROPN
dti-1305	532	23	,	,	PUNCT
dti-1305	532	24	yin	yin	PROPN
dti-1305	532	25	,	,	PUNCT
dti-1305	532	26	h.	h.	PROPN
dti-1305	532	27	,	,	PUNCT
dti-1305	532	28	mckie	mckie	PROPN
dti-1305	532	29	,	,	PUNCT
dti-1305	532	30	j.h	j.h	PROPN
dti-1305	532	31	.	.	PROPN
dti-1305	532	32	et	et	PROPN
dti-1305	532	33	al	al	PROPN
dti-1305	532	34	.	.	PROPN
dti-1305	532	35	1997	1997	NUM
dti-1305	532	36	.	.	PUNCT
dti-1305	533	1	rational	rational	ADJ
dti-1305	533	2	design	design	NOUN
dti-1305	533	3	of	of	ADP
dti-1305	533	4	selective	selective	ADJ
dti-1305	533	5	ligands	ligand	NOUN
dti-1305	533	6	for	for	ADP
dti-1305	533	7	trypanothione	trypanothione	NOUN
dti-1305	533	8	reductase	reductase	NOUN
dti-1305	533	9	from	from	ADP
dti-1305	533	10	trypanosoma	trypanosoma	PROPN
dti-1305	533	11	cruzi	cruzi	PROPN
dti-1305	533	12	.	.	PUNCT
dti-1305	534	1	structural	structural	ADJ
dti-1305	534	2	effects	effect	NOUN
dti-1305	534	3	on	on	ADP
dti-1305	534	4	the	the	DET
dti-1305	534	5	inhibition	inhibition	NOUN
dti-1305	534	6	by	by	ADP
dti-1305	534	7	dibenzazepines	dibenzazepine	NOUN
dti-1305	534	8	based	base	VERB
dti-1305	534	9	on	on	ADP
dti-1305	534	10	imipramine	imipramine	NOUN
dti-1305	534	11	.	.	PUNCT
dti-1305	535	1	j.	j.	PROPN
dti-1305	535	2	enz	enz	PROPN
dti-1305	535	3	.	.	PUNCT
dti-1305	536	1	inhibit	inhibit	PROPN
dti-1305	536	2	.	.	PUNCT
dti-1305	536	3	,	,	PUNCT
dti-1305	536	4	12:161–73	12:161–73	PROPN
dti-1305	536	5	.	.	PUNCT
dti-1305	537	1	girault	girault	NOUN
dti-1305	537	2	,	,	PUNCT
dti-1305	537	3	s.	s.	PROPN
dti-1305	537	4	,	,	PUNCT
dti-1305	537	5	baillet	baillet	PROPN
dti-1305	537	6	,	,	PUNCT
dti-1305	537	7	s.	s.	PROPN
dti-1305	537	8	,	,	PUNCT
dti-1305	537	9	horvath	horvath	PROPN
dti-1305	537	10	,	,	PUNCT
dti-1305	537	11	d.	d.	PROPN
dti-1305	537	12	et	et	PROPN
dti-1305	537	13	al	al	PROPN
dti-1305	537	14	.	.	PROPN
dti-1305	537	15	1997	1997	NUM
dti-1305	537	16	.	.	PUNCT
dti-1305	538	1	new	new	ADJ
dti-1305	538	2	potent	potent	ADJ
dti-1305	538	3	inhibitors	inhibitor	NOUN
dti-1305	538	4	of	of	ADP
dti-1305	538	5	trypanothione	trypanothione	NOUN
dti-1305	538	6	reductase	reductase	NOUN
dti-1305	538	7	from	from	ADP
dti-1305	538	8	trypanosoma	trypanosoma	PROPN
dti-1305	538	9	cruzi	cruzi	PROPN
dti-1305	538	10	in	in	ADP
dti-1305	538	11	the	the	DET
dti-1305	538	12	2	2	NUM
dti-1305	538	13	-	-	PUNCT
dti-1305	538	14	aminodiphenylsulfi	aminodiphenylsulfi	NOUN
dti-1305	538	15	de	de	PROPN
dti-1305	538	16	series	series	PROPN
dti-1305	538	17	.	.	PUNCT
dti-1305	539	1	eur	eur	PROPN
dti-1305	539	2	.	.	PUNCT
dti-1305	540	1	j.	j.	PROPN
dti-1305	540	2	med	med	PROPN
dti-1305	540	3	.	.	PROPN
dti-1305	540	4	chem	chem	PROPN
dti-1305	540	5	.	.	PUNCT
dti-1305	540	6	,	,	PUNCT
dti-1305	541	1	32:39–52	32:39–52	NUM
dti-1305	541	2	.	.	PUNCT
dti-1305	542	1	girault	girault	NOUN
dti-1305	542	2	,	,	PUNCT
dti-1305	542	3	s.	s.	PROPN
dti-1305	542	4	,	,	PUNCT
dti-1305	542	5	davioud	davioud	PROPN
dti-1305	542	6	-	-	PUNCT
dti-1305	542	7	charvet	charvet	NOUN
dti-1305	542	8	,	,	PUNCT
dti-1305	542	9	t.e	t.e	PROPN
dti-1305	542	10	.	.	PROPN
dti-1305	542	11	,	,	PUNCT
dti-1305	542	12	maes	maes	PROPN
dti-1305	542	13	,	,	PUNCT
dti-1305	542	14	l.	l.	PROPN
dti-1305	542	15	et	et	PROPN
dti-1305	542	16	al	al	PROPN
dti-1305	542	17	.	.	PROPN
dti-1305	542	18	2001	2001	NUM
dti-1305	542	19	.	.	PUNCT
dti-1305	543	1	potent	potent	NOUN
dti-1305	543	2	and	and	CCONJ
dti-1305	543	3	specifi	specifi	PROPN
dti-1305	543	4	c	c	PROPN
dti-1305	543	5	inhibitors	inhibitor	NOUN
dti-1305	543	6	of	of	ADP
dti-1305	543	7	trypanothione	trypanothione	NOUN
dti-1305	543	8	reductase	reductase	NOUN
dti-1305	543	9	from	from	ADP
dti-1305	543	10	trypanosoma	trypanosoma	PROPN
dti-1305	543	11	cruzi	cruzi	PROPN
dti-1305	543	12	:	:	PUNCT
dti-1305	543	13	bis(2	bis(2	NOUN
dti-1305	543	14	-	-	PUNCT
dti-1305	543	15	aminodiphenylsulfi	aminodiphenylsulfi	NOUN
dti-1305	543	16	des	des	PROPN
dti-1305	543	17	)	)	PUNCT
dti-1305	543	18	for	for	ADP
dti-1305	543	19	fl	fl	PROPN
dti-1305	543	20	uorescent	uorescent	ADJ
dti-1305	543	21	labeling	labeling	NOUN
dti-1305	543	22	studies	study	NOUN
dti-1305	543	23	.	.	PUNCT
dti-1305	544	1	bioorg	bioorg	PROPN
dti-1305	544	2	.	.	PUNCT
dti-1305	545	1	med	med	PROPN
dti-1305	545	2	.	.	PROPN
dti-1305	545	3	chem	chem	PROPN
dti-1305	545	4	.	.	PUNCT
dti-1305	545	5	,	,	PUNCT
dti-1305	546	1	9:837–46	9:837–46	X
dti-1305	546	2	.	.	PUNCT
dti-1305	547	1	grogl	grogl	PROPN
dti-1305	547	2	,	,	PUNCT
dti-1305	547	3	m.	m.	NOUN
dti-1305	547	4	,	,	PUNCT
dti-1305	547	5	thomason	thomason	PROPN
dti-1305	547	6	,	,	PUNCT
dti-1305	547	7	t.n	t.n	PROPN
dti-1305	547	8	.	.	PROPN
dti-1305	547	9	and	and	CCONJ
dti-1305	547	10	franke	franke	PROPN
dti-1305	547	11	,	,	PUNCT
dti-1305	547	12	e.d	e.d	PROPN
dti-1305	547	13	.	.	PROPN
dti-1305	547	14	,	,	PUNCT
dti-1305	547	15	1992	1992	NUM
dti-1305	547	16	.	.	PUNCT
dti-1305	548	1	drug	drug	NOUN
dti-1305	548	2	resistance	resistance	NOUN
dti-1305	548	3	in	in	ADP
dti-1305	548	4	leishmaniasis	leishmaniasis	NOUN
dti-1305	548	5	:	:	PUNCT
dti-1305	548	6	its	its	PRON
dti-1305	548	7	implication	implication	NOUN
dti-1305	548	8	in	in	ADP
dti-1305	548	9	systemic	systemic	ADJ
dti-1305	548	10	chemotherapy	chemotherapy	NOUN
dti-1305	548	11	of	of	ADP
dti-1305	548	12	cutaneous	cutaneous	ADJ
dti-1305	548	13	and	and	CCONJ
dti-1305	548	14	mucocutaneous	mucocutaneous	ADJ
dti-1305	548	15	disease	disease	NOUN
dti-1305	548	16	.	.	PUNCT
dti-1305	549	1	am	be	AUX
dti-1305	549	2	.	.	PUNCT
dti-1305	550	1	j.	j.	PROPN
dti-1305	550	2	trop	trop	PROPN
dti-1305	550	3	.	.	PUNCT
dti-1305	550	4	med	med	PROPN
dti-1305	550	5	.	.	PUNCT
dti-1305	551	1	hyg	hyg	PROPN
dti-1305	551	2	.	.	PROPN
dti-1305	551	3	,	,	PUNCT
dti-1305	551	4	47:117–26	47:117–26	NOUN
dti-1305	551	5	.	.	PUNCT
dti-1305	552	1	hamilton	hamilton	PROPN
dti-1305	552	2	,	,	PUNCT
dti-1305	552	3	c.j	c.j	PROPN
dti-1305	552	4	.	.	PROPN
dti-1305	552	5	,	,	PUNCT
dti-1305	552	6	saravanamuthu	saravanamuthu	PROPN
dti-1305	552	7	,	,	PUNCT
dti-1305	552	8	a.	a.	PROPN
dti-1305	552	9	,	,	PUNCT
dti-1305	552	10	eggleston	eggleston	PROPN
dti-1305	552	11	,	,	PUNCT
dti-1305	552	12	i.m	i.m	PROPN
dti-1305	552	13	.	.	PROPN
dti-1305	552	14	et	et	PROPN
dti-1305	552	15	al	al	PROPN
dti-1305	552	16	.	.	PROPN
dti-1305	552	17	2003	2003	NUM
dti-1305	552	18	.	.	PUNCT
dti-1305	553	1	ellman’sreagent	ellman’sreagent	ADJ
dti-1305	553	2	-	-	PUNCT
dti-1305	553	3	mediated	mediate	VERB
dti-1305	553	4	regeneration	regeneration	NOUN
dti-1305	553	5	of	of	ADP
dti-1305	553	6	trypanothione	trypanothione	NOUN
dti-1305	553	7	in	in	ADP
dti-1305	553	8	situ	situ	NOUN
dti-1305	553	9	:	:	PUNCT
dti-1305	553	10	substrateeconomical	substrateeconomical	ADJ
dti-1305	553	11	microplate	microplate	NOUN
dti-1305	553	12	and	and	CCONJ
dti-1305	553	13	time	time	NOUN
dti-1305	553	14	-	-	PUNCT
dti-1305	553	15	dependent	dependent	ADJ
dti-1305	553	16	inhibition	inhibition	NOUN
dti-1305	553	17	assays	assay	NOUN
dti-1305	553	18	for	for	ADP
dti-1305	553	19	trypanothione	trypanothione	NOUN
dti-1305	553	20	reductase	reductase	NOUN
dti-1305	553	21	.	.	PUNCT
dti-1305	554	1	biochem	biochem	PROPN
dti-1305	554	2	.	.	PUNCT
dti-1305	555	1	j.	j.	PROPN
dti-1305	555	2	,	,	PUNCT
dti-1305	555	3	369:529–537	369:529–537	PROPN
dti-1305	555	4	.	.	PUNCT
dti-1305	556	1	hamilton	hamilton	PROPN
dti-1305	556	2	,	,	PUNCT
dti-1305	556	3	c.j	c.j	PROPN
dti-1305	556	4	.	.	PROPN
dti-1305	556	5	,	,	PUNCT
dti-1305	556	6	saravanamuthu	saravanamuthu	PROPN
dti-1305	556	7	,	,	PUNCT
dti-1305	556	8	a.	a.	NOUN
dti-1305	556	9	,	,	PUNCT
dti-1305	556	10	poupat	poupat	NOUN
dti-1305	556	11	,	,	PUNCT
dti-1305	556	12	c.	c.	PROPN
dti-1305	556	13	et	et	PROPN
dti-1305	556	14	al	al	PROPN
dti-1305	556	15	.	.	PROPN
dti-1305	556	16	2006	2006	NUM
dti-1305	556	17	.	.	PUNCT
dti-1305	557	1	time	time	NOUN
dti-1305	557	2	-	-	PUNCT
dti-1305	557	3	dependent	dependent	ADJ
dti-1305	557	4	inhibitors	inhibitor	NOUN
dti-1305	557	5	of	of	ADP
dti-1305	557	6	trypanothione	trypanothione	NOUN
dti-1305	557	7	reductase	reductase	NOUN
dti-1305	557	8	:	:	PUNCT
dti-1305	557	9	analogues	analogue	NOUN
dti-1305	557	10	of	of	ADP
dti-1305	557	11	the	the	DET
dti-1305	557	12	spermidine	spermidine	NOUN
dti-1305	557	13	alkaloid	alkaloid	PROPN
dti-1305	557	14	lunarine	lunarine	PROPN
dti-1305	557	15	and	and	CCONJ
dti-1305	557	16	related	relate	VERB
dti-1305	557	17	natural	natural	ADJ
dti-1305	557	18	products	product	NOUN
dti-1305	557	19	.	.	PUNCT
dti-1305	558	1	bioorg	bioorg	VERB
dti-1305	558	2	.	.	PUNCT
dti-1305	559	1	med	med	PROPN
dti-1305	559	2	.	.	PROPN
dti-1305	559	3	chem	chem	PROPN
dti-1305	559	4	.	.	PUNCT
dti-1305	559	5	,	,	PUNCT
dti-1305	559	6	14:2266–78	14:2266–78	NUM
dti-1305	559	7	.	.	PUNCT
dti-1305	560	1	henderson	henderson	PROPN
dti-1305	560	2	,	,	PUNCT
dti-1305	560	3	g.b	g.b	PROPN
dti-1305	560	4	.	.	PROPN
dti-1305	560	5	,	,	PUNCT
dti-1305	560	6	fairlamb	fairlamb	PROPN
dti-1305	560	7	,	,	PUNCT
dti-1305	560	8	a.h	a.h	PROPN
dti-1305	560	9	.	.	PROPN
dti-1305	560	10	and	and	CCONJ
dti-1305	560	11	cerami	cerami	PROPN
dti-1305	560	12	,	,	PUNCT
dti-1305	560	13	a.	a.	NOUN
dti-1305	560	14	1987a	1987a	NUM
dti-1305	560	15	.	.	PUNCT
dti-1305	561	1	trypanothione	trypanothione	NOUN
dti-1305	561	2	dependent	dependent	ADJ
dti-1305	561	3	peroxide	peroxide	NOUN
dti-1305	561	4	metabolism	metabolism	NOUN
dti-1305	561	5	in	in	ADP
dti-1305	561	6	crithidia	crithidia	NOUN
dti-1305	561	7	fasciculata	fasciculata	NOUN
dti-1305	561	8	and	and	CCONJ
dti-1305	561	9	trypanosoma	trypanosoma	PROPN
dti-1305	561	10	brucei	brucei	PROPN
dti-1305	561	11	.	.	PUNCT
dti-1305	562	1	mol	mol	PROPN
dti-1305	562	2	.	.	PROPN
dti-1305	562	3	biochem	biochem	PROPN
dti-1305	562	4	.	.	PUNCT
dti-1305	563	1	parasitol	parasitol	NOUN
dti-1305	563	2	.	.	PUNCT
dti-1305	563	3	,	,	PUNCT
dti-1305	563	4	24:39–45	24:39–45	NUM
dti-1305	563	5	.	.	PUNCT
dti-1305	564	1	henderson	henderson	PROPN
dti-1305	564	2	,	,	PUNCT
dti-1305	564	3	g.b	g.b	PROPN
dti-1305	564	4	.	.	PROPN
dti-1305	564	5	,	,	PUNCT
dti-1305	564	6	fairlamb	fairlamb	PROPN
dti-1305	564	7	,	,	PUNCT
dti-1305	564	8	a.h	a.h	PROPN
dti-1305	564	9	.	.	PROPN
dti-1305	564	10	,	,	PUNCT
dti-1305	564	11	ulrich	ulrich	PROPN
dti-1305	564	12	,	,	PUNCT
dti-1305	564	13	p.	p.	NOUN
dti-1305	564	14	et	et	NOUN
dti-1305	565	1	al	al	PROPN
dti-1305	565	2	.	.	PROPN
dti-1305	565	3	1987b	1987b	PROPN
dti-1305	565	4	.	.	PUNCT
dti-1305	566	1	substrate	substrate	NOUN
dti-1305	566	2	specifi	specifi	PROPN
dti-1305	566	3	city	city	PROPN
dti-1305	566	4	of	of	ADP
dti-1305	566	5	the	the	DET
dti-1305	566	6	fl	fl	PROPN
dti-1305	566	7	avoprotein	avoprotein	NOUN
dti-1305	566	8	trypanothione	trypanothione	PROPN
dti-1305	566	9	disulfi	disulfi	PROPN
dti-1305	566	10	de	de	X
dti-1305	566	11	reductase	reductase	NOUN
dti-1305	566	12	from	from	ADP
dti-1305	566	13	crithidia	crithidia	PROPN
dti-1305	566	14	fasciculata	fasciculata	NOUN
dti-1305	566	15	.	.	PUNCT
dti-1305	567	1	biochemistry	biochemistry	NOUN
dti-1305	567	2	,	,	PUNCT
dti-1305	567	3	26:3023–7	26:3023–7	NUM
dti-1305	567	4	.	.	PUNCT
dti-1305	568	1	henderson	henderson	PROPN
dti-1305	568	2	,	,	PUNCT
dti-1305	568	3	g.b	g.b	PROPN
dti-1305	568	4	.	.	PROPN
dti-1305	568	5	,	,	PUNCT
dti-1305	568	6	ulrich	ulrich	PROPN
dti-1305	568	7	,	,	PUNCT
dti-1305	568	8	p.	p.	NOUN
dti-1305	568	9	,	,	PUNCT
dti-1305	568	10	fairlamb	fairlamb	PROPN
dti-1305	568	11	,	,	PUNCT
dti-1305	568	12	a.h	a.h	PROPN
dti-1305	568	13	.	.	PROPN
dti-1305	568	14	et	et	PROPN
dti-1305	568	15	al	al	PROPN
dti-1305	568	16	.	.	PROPN
dti-1305	568	17	1988	1988	NUM
dti-1305	568	18	.	.	PUNCT
dti-1305	569	1	“	"	PUNCT
dti-1305	569	2	subversive	subversive	ADJ
dti-1305	569	3	”	"	PUNCT
dti-1305	569	4	substrates	substrate	NOUN
dti-1305	569	5	for	for	ADP
dti-1305	569	6	the	the	DET
dti-1305	569	7	enzyme	enzyme	NOUN
dti-1305	569	8	trypanothione	trypanothione	NOUN
dti-1305	569	9	disulfi	disulfi	NOUN
dti-1305	569	10	de	de	X
dti-1305	569	11	reductase	reductase	NOUN
dti-1305	569	12	:	:	PUNCT
dti-1305	569	13	alternative	alternative	ADJ
dti-1305	569	14	approach	approach	NOUN
dti-1305	569	15	to	to	ADP
dti-1305	569	16	chemotherapy	chemotherapy	NOUN
dti-1305	569	17	of	of	ADP
dti-1305	569	18	chagas	chagas	PROPN
dti-1305	569	19	disease	disease	NOUN
dti-1305	569	20	.	.	PUNCT
dti-1305	570	1	proce	proce	PROPN
dti-1305	570	2	.	.	PUNCT
dti-1305	570	3	natl	natl	PROPN
dti-1305	570	4	.	.	PUNCT
dti-1305	571	1	acad	acad	PROPN
dti-1305	571	2	.	.	PUNCT
dti-1305	572	1	sci	sci	PROPN
dti-1305	572	2	.	.	PROPN
dti-1305	572	3	u.s.a	u.s.a	PROPN
dti-1305	572	4	,	,	PUNCT
dti-1305	572	5	,	,	PUNCT
dti-1305	572	6	85:5374–8	85:5374–8	NUM
dti-1305	572	7	.	.	PUNCT
dti-1305	573	1	hyde	hyde	PROPN
dti-1305	573	2	,	,	PUNCT
dti-1305	573	3	j.e	j.e	PROPN
dti-1305	573	4	.	.	PROPN
dti-1305	573	5	,	,	PUNCT
dti-1305	573	6	1990	1990	NUM
dti-1305	573	7	.	.	PUNCT
dti-1305	574	1	molecular	molecular	ADJ
dti-1305	574	2	parasitology	parasitology	NOUN
dti-1305	574	3	.	.	PUNCT
dti-1305	575	1	milton	milton	PROPN
dti-1305	575	2	keynes	keynes	PROPN
dti-1305	575	3	:	:	PUNCT
dti-1305	575	4	open	open	ADJ
dti-1305	575	5	university	university	NOUN
dti-1305	575	6	press	press	NOUN
dti-1305	575	7	.	.	PUNCT
dti-1305	576	1	hunter	hunter	NOUN
dti-1305	576	2	,	,	PUNCT
dti-1305	576	3	w.n	w.n	PROPN
dti-1305	576	4	.	.	PROPN
dti-1305	576	5	,	,	PUNCT
dti-1305	576	6	bailey	bailey	PROPN
dti-1305	576	7	,	,	PUNCT
dti-1305	576	8	s.	s.	PROPN
dti-1305	576	9	,	,	PUNCT
dti-1305	576	10	habash	habash	PROPN
dti-1305	576	11	,	,	PUNCT
dti-1305	576	12	j.	j.	PROPN
dti-1305	576	13	et	et	PROPN
dti-1305	576	14	al	al	PROPN
dti-1305	576	15	.	.	PROPN
dti-1305	576	16	1992	1992	NUM
dti-1305	576	17	.	.	PUNCT
dti-1305	577	1	active	active	ADJ
dti-1305	577	2	site	site	NOUN
dti-1305	577	3	of	of	ADP
dti-1305	577	4	trypanothione	trypanothione	PROPN
dti-1305	577	5	reductase	reductase	NOUN
dti-1305	577	6	.	.	PUNCT
dti-1305	578	1	a	a	DET
dti-1305	578	2	target	target	NOUN
dti-1305	578	3	for	for	ADP
dti-1305	578	4	rational	rational	ADJ
dti-1305	578	5	drug	drug	NOUN
dti-1305	578	6	design	design	NOUN
dti-1305	578	7	.	.	PUNCT
dti-1305	579	1	j.	j.	PROPN
dti-1305	579	2	mol	mol	PROPN
dti-1305	579	3	.	.	PUNCT
dti-1305	580	1	biol	biol	PROPN
dti-1305	580	2	.	.	PUNCT
dti-1305	580	3	,	,	PUNCT
dti-1305	581	1	227:322–33	227:322–33	PROPN
dti-1305	581	2	.	.	PUNCT
dti-1305	581	3	inhoff	inhoff	PROPN
dti-1305	581	4	,	,	PUNCT
dti-1305	581	5	o.	o.	PROPN
dti-1305	581	6	,	,	PUNCT
dti-1305	581	7	richards	richard	NOUN
dti-1305	581	8	,	,	PUNCT
dti-1305	581	9	j.m	j.m	PROPN
dti-1305	581	10	.	.	PROPN
dti-1305	581	11	,	,	PUNCT
dti-1305	581	12	briet	briet	PROPN
dti-1305	581	13	,	,	PUNCT
dti-1305	581	14	j.w	j.w	PROPN
dti-1305	581	15	.	.	PROPN
dti-1305	581	16	et	et	PROPN
dti-1305	581	17	al	al	PROPN
dti-1305	581	18	.	.	PROPN
dti-1305	581	19	2002	2002	NUM
dti-1305	581	20	.	.	PUNCT
dti-1305	582	1	coupling	coupling	NOUN
dti-1305	582	2	of	of	ADP
dti-1305	582	3	a	a	DET
dti-1305	582	4	competitive	competitive	ADJ
dti-1305	582	5	and	and	CCONJ
dti-1305	582	6	an	an	DET
dti-1305	582	7	irreversible	irreversible	ADJ
dti-1305	582	8	ligand	ligand	NOUN
dti-1305	582	9	generates	generate	VERB
dti-1305	582	10	mixed	mixed	ADJ
dti-1305	582	11	type	type	NOUN
dti-1305	582	12	inhibitors	inhibitor	NOUN
dti-1305	582	13	of	of	ADP
dti-1305	582	14	trypanosoma	trypanosoma	NOUN
dti-1305	582	15	cruzi	cruzi	PROPN
dti-1305	582	16	trypanothione	trypanothione	PROPN
dti-1305	582	17	reductase	reductase	NOUN
dti-1305	582	18	.	.	PUNCT
dti-1305	583	1	j.	j.	PROPN
dti-1305	583	2	med	med	PROPN
dti-1305	583	3	.	.	PROPN
dti-1305	583	4	chem	chem	PROPN
dti-1305	583	5	.	.	PUNCT
dti-1305	583	6	,	,	PUNCT
dti-1305	583	7	45:4524–30	45:4524–30	PROPN
dti-1305	583	8	.	.	PUNCT
dti-1305	584	1	jacoby	jacoby	PROPN
dti-1305	584	2	,	,	PUNCT
dti-1305	584	3	e.m	e.m	PROPN
dti-1305	584	4	.	.	PROPN
dti-1305	584	5	,	,	PUNCT
dti-1305	584	6	schlichting	schlichting	PROPN
dti-1305	584	7	,	,	PUNCT
dti-1305	584	8	i.	i.	NOUN
dti-1305	584	9	,	,	PUNCT
dti-1305	584	10	lantwin	lantwin	PROPN
dti-1305	584	11	,	,	PUNCT
dti-1305	584	12	c.b	c.b	PROPN
dti-1305	584	13	.	.	PROPN
dti-1305	584	14	et	et	PROPN
dti-1305	584	15	al	al	PROPN
dti-1305	584	16	.	.	PROPN
dti-1305	584	17	1996	1996	NUM
dti-1305	584	18	.	.	PUNCT
dti-1305	585	1	crystal	crystal	NOUN
dti-1305	585	2	structure	structure	NOUN
dti-1305	585	3	of	of	ADP
dti-1305	585	4	the	the	DET
dti-1305	585	5	trypanosoma	trypanosoma	NOUN
dti-1305	585	6	cruzi	cruzi	PROPN
dti-1305	585	7	trypanothione	trypanothione	PROPN
dti-1305	585	8	reductase.mepacrine	reductase.mepacrine	PROPN
dti-1305	585	9	complex	complex	NOUN
dti-1305	585	10	.	.	PUNCT
dti-1305	586	1	proteins	protein	NOUN
dti-1305	586	2	,	,	PUNCT
dti-1305	586	3	24:73–80	24:73–80	PROPN
dti-1305	586	4	.	.	PUNCT
dti-1305	587	1	kelly	kelly	PROPN
dti-1305	587	2	,	,	PUNCT
dti-1305	587	3	j.m	j.m	PROPN
dti-1305	587	4	.	.	PROPN
dti-1305	587	5	,	,	PUNCT
dti-1305	587	6	taylor	taylor	PROPN
dti-1305	587	7	,	,	PUNCT
dti-1305	587	8	m.c	m.c	PROPN
dti-1305	587	9	.	.	PROPN
dti-1305	587	10	,	,	PUNCT
dti-1305	587	11	smith	smith	PROPN
dti-1305	587	12	,	,	PUNCT
dti-1305	587	13	k.	k.	PROPN
dti-1305	587	14	et	et	PROPN
dti-1305	587	15	al	al	PROPN
dti-1305	587	16	.	.	PROPN
dti-1305	587	17	1993	1993	NUM
dti-1305	587	18	.	.	PUNCT
dti-1305	588	1	phenotype	phenotype	NOUN
dti-1305	588	2	of	of	ADP
dti-1305	588	3	recombinant	recombinant	ADJ
dti-1305	588	4	leishmania	leishmania	NOUN
dti-1305	588	5	donovani	donovani	NOUN
dti-1305	588	6	and	and	CCONJ
dti-1305	588	7	trypanosoma	trypanosoma	PROPN
dti-1305	588	8	cruzi	cruzi	PROPN
dti-1305	588	9	which	which	DET
dti-1305	588	10	overexpress	overexpress	NOUN
dti-1305	588	11	trypanothione	trypanothione	NOUN
dti-1305	588	12	reductase	reductase	NOUN
dti-1305	588	13	.	.	PUNCT
dti-1305	589	1	sensitivity	sensitivity	NOUN
dti-1305	589	2	towards	towards	ADP
dti-1305	589	3	agents	agent	NOUN
dti-1305	589	4	that	that	PRON
dti-1305	589	5	are	be	AUX
dti-1305	589	6	thought	think	VERB
dti-1305	589	7	to	to	PART
dti-1305	589	8	induce	induce	VERB
dti-1305	589	9	oxidative	oxidative	ADJ
dti-1305	589	10	stress	stress	NOUN
dti-1305	589	11	.	.	PUNCT
dti-1305	590	1	eur	eur	PROPN
dti-1305	590	2	.	.	PUNCT
dti-1305	591	1	j.	j.	PROPN
dti-1305	591	2	biochem	biochem	PROPN
dti-1305	591	3	.	.	PUNCT
dti-1305	592	1	/	/	PUNCT
dti-1305	592	2	febs	febs	NOUN
dti-1305	592	3	.	.	PUNCT
dti-1305	593	1	,	,	PUNCT
dti-1305	594	1	218:29–37	218:29–37	X
dti-1305	594	2	.	.	PUNCT
dti-1305	595	1	khan	khan	PROPN
dti-1305	595	2	,	,	PUNCT
dti-1305	595	3	m.o.f	m.o.f	ADJ
dti-1305	595	4	.	.	PROPN
dti-1305	595	5	,	,	PUNCT
dti-1305	595	6	austin	austin	PROPN
dti-1305	595	7	,	,	PUNCT
dti-1305	595	8	s.e	s.e	PROPN
dti-1305	595	9	.	.	PROPN
dti-1305	595	10	,	,	PUNCT
dti-1305	595	11	chan	chan	PROPN
dti-1305	595	12	,	,	PUNCT
dti-1305	595	13	c.	c.	PROPN
dti-1305	595	14	et	et	PROPN
dti-1305	595	15	al	al	PROPN
dti-1305	595	16	.	.	PROPN
dti-1305	595	17	2000	2000	NUM
dti-1305	595	18	.	.	PUNCT
dti-1305	596	1	use	use	NOUN
dti-1305	596	2	of	of	ADP
dti-1305	596	3	an	an	DET
dti-1305	596	4	additional	additional	ADJ
dti-1305	596	5	hydrophobic	hydrophobic	NOUN
dti-1305	596	6	binding	bind	VERB
dti-1305	596	7	site	site	NOUN
dti-1305	596	8	,	,	PUNCT
dti-1305	596	9	the	the	DET
dti-1305	596	10	z	z	NOUN
dti-1305	596	11	site	site	NOUN
dti-1305	596	12	,	,	PUNCT
dti-1305	596	13	in	in	ADP
dti-1305	596	14	the	the	DET
dti-1305	596	15	rational	rational	ADJ
dti-1305	596	16	drug	drug	NOUN
dti-1305	596	17	design	design	NOUN
dti-1305	596	18	of	of	ADP
dti-1305	596	19	a	a	DET
dti-1305	596	20	new	new	ADJ
dti-1305	596	21	class	class	NOUN
dti-1305	596	22	of	of	ADP
dti-1305	596	23	stronger	strong	ADJ
dti-1305	596	24	trypanothione	trypanothione	NOUN
dti-1305	596	25	reductase	reductase	NOUN
dti-1305	596	26	inhibitor	inhibitor	NOUN
dti-1305	596	27	,	,	PUNCT
dti-1305	596	28	quaternary	quaternary	ADJ
dti-1305	596	29	alkylammonium	alkylammonium	NOUN
dti-1305	596	30	phenothiazines	phenothiazine	NOUN
dti-1305	596	31	.	.	PUNCT
dti-1305	597	1	j.	j.	PROPN
dti-1305	597	2	med	med	PROPN
dti-1305	597	3	.	.	PROPN
dti-1305	597	4	chem	chem	PROPN
dti-1305	597	5	.	.	PUNCT
dti-1305	597	6	,	,	PUNCT
dti-1305	597	7	43:3148–56	43:3148–56	NUM
dti-1305	597	8	.	.	PUNCT
dti-1305	598	1	koenig	koenig	PROPN
dti-1305	598	2	,	,	PUNCT
dti-1305	598	3	k.	k.	PROPN
dti-1305	598	4	,	,	PUNCT
dti-1305	598	5	menge	menge	PROPN
dti-1305	598	6	,	,	PUNCT
dti-1305	598	7	u.	u.	PROPN
dti-1305	598	8	,	,	PUNCT
dti-1305	598	9	kiess	kiess	PROPN
dti-1305	598	10	,	,	PUNCT
dti-1305	598	11	m.	m.	NOUN
dti-1305	598	12	et	et	PROPN
dti-1305	598	13	al	al	PROPN
dti-1305	598	14	.	.	PROPN
dti-1305	598	15	1997	1997	NUM
dti-1305	598	16	.	.	PUNCT
dti-1305	599	1	convenient	convenient	ADJ
dti-1305	599	2	isolation	isolation	NOUN
dti-1305	599	3	and	and	CCONJ
dti-1305	599	4	kinetic	kinetic	ADJ
dti-1305	599	5	mechanism	mechanism	NOUN
dti-1305	599	6	of	of	ADP
dti-1305	599	7	glutathionylspermidine	glutathionylspermidine	ADJ
dti-1305	599	8	synthetase	synthetase	NOUN
dti-1305	599	9	from	from	ADP
dti-1305	599	10	crithidia	crithidia	NOUN
dti-1305	599	11	fasciculata	fasciculata	NOUN
dti-1305	599	12	.	.	PUNCT
dti-1305	600	1	j.	j.	PROPN
dti-1305	600	2	biol	biol	PROPN
dti-1305	600	3	.	.	PUNCT
dti-1305	601	1	chem	chem	PROPN
dti-1305	601	2	.	.	PUNCT
dti-1305	601	3	,	,	PUNCT
dti-1305	602	1	272:11908–11915	272:11908–11915	NUM
dti-1305	602	2	.	.	PUNCT
dti-1305	603	1	krauth	krauth	NOUN
dti-1305	603	2	-	-	PUNCT
dti-1305	603	3	siegel	siegel	PROPN
dti-1305	603	4	,	,	PUNCT
dti-1305	603	5	r.l	r.l	PROPN
dti-1305	603	6	.	.	PROPN
dti-1305	603	7	,	,	PUNCT
dti-1305	603	8	enders	ender	NOUN
dti-1305	603	9	,	,	PUNCT
dti-1305	603	10	b.	b.	PROPN
dti-1305	603	11	,	,	PUNCT
dti-1305	603	12	henderson	henderson	PROPN
dti-1305	603	13	,	,	PUNCT
dti-1305	603	14	g.b	g.b	PROPN
dti-1305	603	15	.	.	PROPN
dti-1305	603	16	et	et	PROPN
dti-1305	603	17	al	al	PROPN
dti-1305	603	18	.	.	PROPN
dti-1305	603	19	1987	1987	NUM
dti-1305	603	20	.	.	PUNCT
dti-1305	604	1	trypanothione	trypanothione	NOUN
dti-1305	604	2	reductase	reductase	NOUN
dti-1305	604	3	from	from	ADP
dti-1305	604	4	trypanosoma	trypanosoma	PROPN
dti-1305	604	5	cruzi	cruzi	PROPN
dti-1305	604	6	.	.	PUNCT
dti-1305	605	1	purifi	purifi	PROPN
dti-1305	605	2	cation	cation	NOUN
dti-1305	605	3	and	and	CCONJ
dti-1305	605	4	characterization	characterization	NOUN
dti-1305	605	5	of	of	ADP
dti-1305	605	6	the	the	DET
dti-1305	605	7	crystalline	crystalline	ADJ
dti-1305	605	8	enzyme	enzyme	NOUN
dti-1305	605	9	.	.	PUNCT
dti-1305	606	1	eur	eur	PROPN
dti-1305	606	2	.	.	PUNCT
dti-1305	607	1	j.	j.	PROPN
dti-1305	607	2	biochem	biochem	PROPN
dti-1305	607	3	.	.	PUNCT
dti-1305	607	4	,	,	PUNCT
dti-1305	607	5	164:123–8	164:123–8	NUM
dti-1305	607	6	.	.	PUNCT
dti-1305	608	1	krauth	krauth	NOUN
dti-1305	608	2	-	-	PUNCT
dti-1305	608	3	siegel	siegel	PROPN
dti-1305	608	4	,	,	PUNCT
dti-1305	608	5	r.l	r.l	PROPN
dti-1305	608	6	.	.	PROPN
dti-1305	608	7	and	and	CCONJ
dti-1305	608	8	schoneck	schoneck	PROPN
dti-1305	608	9	,	,	PUNCT
dti-1305	608	10	r.	r.	PROPN
dti-1305	608	11	,	,	PUNCT
dti-1305	608	12	1995	1995	NUM
dti-1305	608	13	.	.	PUNCT
dti-1305	609	1	flavoprotein	flavoprotein	ADJ
dti-1305	609	2	structure	structure	NOUN
dti-1305	609	3	and	and	CCONJ
dti-1305	609	4	mechanism	mechanism	NOUN
dti-1305	609	5	.	.	PUNCT
dti-1305	610	1	5	5	X
dti-1305	610	2	.	.	PUNCT
dti-1305	610	3	trypanothione	trypanothione	NOUN
dti-1305	610	4	reductase	reductase	NOUN
dti-1305	610	5	and	and	CCONJ
dti-1305	610	6	lipoamide	lipoamide	ADJ
dti-1305	610	7	dehydrogenase	dehydrogenase	NOUN
dti-1305	610	8	as	as	ADP
dti-1305	610	9	targets	target	NOUN
dti-1305	610	10	for	for	ADP
dti-1305	610	11	a	a	DET
dti-1305	610	12	structure	structure	NOUN
dti-1305	610	13	-	-	PUNCT
dti-1305	610	14	based	base	VERB
dti-1305	610	15	drug	drug	NOUN
dti-1305	610	16	design	design	NOUN
dti-1305	610	17	.	.	PUNCT
dti-1305	611	1	faseb	faseb	PROPN
dti-1305	611	2	.	.	PUNCT
dti-1305	612	1	j.	j.	PROPN
dti-1305	612	2	,	,	PUNCT
dti-1305	612	3	9:1138–46	9:1138–46	PROPN
dti-1305	612	4	.	.	PUNCT
dti-1305	613	1	kuriyan	kuriyan	PROPN
dti-1305	613	2	,	,	PUNCT
dti-1305	613	3	j.	j.	PROPN
dti-1305	613	4	,	,	PUNCT
dti-1305	613	5	kong	kong	PROPN
dti-1305	613	6	,	,	PUNCT
dti-1305	613	7	x.p	x.p	PROPN
dti-1305	613	8	.	.	PROPN
dti-1305	613	9	,	,	PUNCT
dti-1305	613	10	krishna	krishna	PROPN
dti-1305	613	11	,	,	PUNCT
dti-1305	613	12	t.s	t.s	PROPN
dti-1305	613	13	.	.	PROPN
dti-1305	613	14	et	et	PROPN
dti-1305	613	15	al	al	PROPN
dti-1305	613	16	.	.	PROPN
dti-1305	613	17	1991	1991	NUM
dti-1305	613	18	.	.	PUNCT
dti-1305	614	1	x	x	X
dti-1305	614	2	-	-	PUNCT
dti-1305	614	3	ray	ray	NOUN
dti-1305	614	4	structure	structure	NOUN
dti-1305	614	5	of	of	ADP
dti-1305	614	6	trypanothione	trypanothione	PROPN
dti-1305	614	7	reductase	reductase	NOUN
dti-1305	614	8	from	from	ADP
dti-1305	614	9	crithidia	crithidia	NOUN
dti-1305	614	10	fasciculata	fasciculata	NOUN
dti-1305	614	11	at	at	ADP
dti-1305	614	12	2.4	2.4	NUM
dti-1305	614	13	-	-	PUNCT
dti-1305	614	14	å	å	NOUN
dti-1305	614	15	resolution	resolution	NOUN
dti-1305	614	16	.	.	PUNCT
dti-1305	615	1	proc	proc	PROPN
dti-1305	615	2	.	.	PUNCT
dti-1305	616	1	natl	natl	PROPN
dti-1305	616	2	.	.	PUNCT
dti-1305	617	1	acad	acad	PROPN
dti-1305	617	2	.	.	PUNCT
dti-1305	618	1	sci	sci	PROPN
dti-1305	618	2	.	.	PROPN
dti-1305	618	3	,	,	PUNCT
dti-1305	618	4	u.s.a	u.s.a	PROPN
dti-1305	618	5	.	.	PROPN
dti-1305	618	6	,	,	PUNCT
dti-1305	618	7	88:8764–8	88:8764–8	NUM
dti-1305	618	8	.	.	PUNCT
dti-1305	619	1	lantwin	lantwin	PROPN
dti-1305	619	2	,	,	PUNCT
dti-1305	619	3	c.b	c.b	PROPN
dti-1305	619	4	.	.	PROPN
dti-1305	619	5	,	,	PUNCT
dti-1305	619	6	schlichting	schlichting	PROPN
dti-1305	619	7	,	,	PUNCT
dti-1305	619	8	i.	i.	PROPN
dti-1305	619	9	,	,	PUNCT
dti-1305	619	10	kabsch	kabsch	PROPN
dti-1305	619	11	,	,	PUNCT
dti-1305	619	12	w.	w.	PROPN
dti-1305	619	13	et	et	PROPN
dti-1305	619	14	al	al	PROPN
dti-1305	619	15	.	.	PROPN
dti-1305	619	16	1994	1994	NUM
dti-1305	619	17	.	.	PUNCT
dti-1305	620	1	the	the	DET
dti-1305	620	2	structure	structure	NOUN
dti-1305	620	3	of	of	ADP
dti-1305	620	4	trypanosoma	trypanosoma	PROPN
dti-1305	620	5	cruzi	cruzi	PROPN
dti-1305	620	6	trypanothione	trypanothione	PROPN
dti-1305	620	7	reductase	reductase	NOUN
dti-1305	620	8	in	in	ADP
dti-1305	620	9	the	the	DET
dti-1305	620	10	oxidized	oxidized	ADJ
dti-1305	620	11	and	and	CCONJ
dti-1305	620	12	nadph	nadph	ADJ
dti-1305	620	13	reduced	reduce	VERB
dti-1305	620	14	state	state	NOUN
dti-1305	620	15	.	.	PUNCT
dti-1305	621	1	proteins	protein	NOUN
dti-1305	621	2	,	,	PUNCT
dti-1305	621	3	18:161–73	18:161–73	X
dti-1305	621	4	.	.	PUNCT
dti-1305	622	1	le	le	PROPN
dti-1305	622	2	trant	trant	PROPN
dti-1305	622	3	,	,	PUNCT
dti-1305	622	4	n.	n.	PROPN
dti-1305	622	5	,	,	PUNCT
dti-1305	622	6	meshnick	meshnick	PROPN
dti-1305	622	7	,	,	PUNCT
dti-1305	622	8	s.r	s.r	PROPN
dti-1305	622	9	.	.	PROPN
dti-1305	622	10	,	,	PUNCT
dti-1305	622	11	kitchener	kitchener	PROPN
dti-1305	622	12	,	,	PUNCT
dti-1305	622	13	k.	k.	PROPN
dti-1305	622	14	,	,	PUNCT
dti-1305	622	15	eaton	eaton	PROPN
dti-1305	622	16	,	,	PUNCT
dti-1305	622	17	j.w	j.w	PROPN
dti-1305	622	18	.	.	PROPN
dti-1305	622	19	and	and	CCONJ
dti-1305	622	20	cerami	cerami	PROPN
dti-1305	622	21	,	,	PUNCT
dti-1305	622	22	a.	a.	NOUN
dti-1305	622	23	1983	1983	NUM
dti-1305	622	24	.	.	PUNCT
dti-1305	623	1	iron	iron	NOUN
dti-1305	623	2	-	-	PUNCT
dti-1305	623	3	containing	contain	VERB
dti-1305	623	4	superoxide	superoxide	NOUN
dti-1305	623	5	dismutase	dismutase	NOUN
dti-1305	623	6	from	from	ADP
dti-1305	623	7	crithidia	crithidia	NOUN
dti-1305	623	8	fasciculata	fasciculata	PROPN
dti-1305	623	9	.	.	PUNCT
dti-1305	624	1	purifi	purifi	ADJ
dti-1305	624	2	cation	cation	NOUN
dti-1305	624	3	,	,	PUNCT
dti-1305	624	4	characterization	characterization	NOUN
dti-1305	624	5	,	,	PUNCT
dti-1305	624	6	and	and	CCONJ
dti-1305	624	7	similarity	similarity	NOUN
dti-1305	624	8	to	to	ADP
dti-1305	624	9	leishmanial	leishmanial	ADJ
dti-1305	624	10	and	and	CCONJ
dti-1305	624	11	trypanosomal	trypanosomal	ADJ
dti-1305	624	12	enzymes	enzyme	NOUN
dti-1305	624	13	.	.	PUNCT
dti-1305	625	1	j.	j.	PROPN
dti-1305	625	2	biol	biol	PROPN
dti-1305	625	3	.	.	PUNCT
dti-1305	626	1	chem	chem	PROPN
dti-1305	626	2	.	.	PUNCT
dti-1305	626	3	,	,	PUNCT
dti-1305	627	1	258:125–30	258:125–30	NUM
dti-1305	627	2	.	.	PUNCT
dti-1305	628	1	lee	lee	PROPN
dti-1305	628	2	,	,	PUNCT
dti-1305	628	3	b.	b.	PROPN
dti-1305	628	4	,	,	PUNCT
dti-1305	628	5	bauer	bauer	PROPN
dti-1305	628	6	,	,	PUNCT
dti-1305	628	7	h.	h.	PROPN
dti-1305	628	8	,	,	PUNCT
dti-1305	628	9	melchers	melchers	PROPN
dti-1305	628	10	,	,	PUNCT
dti-1305	628	11	j.	j.	PROPN
dti-1305	628	12	et	et	PROPN
dti-1305	628	13	al	al	PROPN
dti-1305	628	14	.	.	PROPN
dti-1305	628	15	2005	2005	NUM
dti-1305	628	16	.	.	PUNCT
dti-1305	629	1	irreversible	irreversible	ADJ
dti-1305	629	2	inactivation	inactivation	NOUN
dti-1305	629	3	of	of	ADP
dti-1305	629	4	trypanothione	trypanothione	NOUN
dti-1305	629	5	reductase	reductase	NOUN
dti-1305	629	6	by	by	ADP
dti-1305	629	7	unsaturated	unsaturated	ADJ
dti-1305	629	8	mannich	mannich	NOUN
dti-1305	629	9	bases	basis	NOUN
dti-1305	629	10	:	:	PUNCT
dti-1305	629	11	a	a	DET
dti-1305	629	12	divinyl	divinyl	ADJ
dti-1305	629	13	ketone	ketone	NOUN
dti-1305	629	14	as	as	ADP
dti-1305	629	15	key	key	ADJ
dti-1305	629	16	intermediate	intermediate	NOUN
dti-1305	629	17	.	.	PUNCT
dti-1305	630	1	j.	j.	PROPN
dti-1305	630	2	med	med	PROPN
dti-1305	630	3	.	.	PROPN
dti-1305	630	4	chem	chem	PROPN
dti-1305	630	5	.	.	PUNCT
dti-1305	630	6	,	,	PUNCT
dti-1305	630	7	48:7400–10	48:7400–10	NOUN
dti-1305	630	8	.	.	PUNCT
dti-1305	631	1	li	li	PROPN
dti-1305	631	2	,	,	PUNCT
dti-1305	631	3	z.	z.	PROPN
dti-1305	631	4	,	,	PUNCT
dti-1305	631	5	fennie	fennie	PROPN
dti-1305	631	6	,	,	PUNCT
dti-1305	631	7	m.w	m.w	PROPN
dti-1305	631	8	.	.	PROPN
dti-1305	631	9	,	,	PUNCT
dti-1305	631	10	ganem	ganem	PROPN
dti-1305	631	11	,	,	PUNCT
dti-1305	631	12	b.	b.	PROPN
dti-1305	631	13	et	et	PROPN
dti-1305	631	14	al	al	PROPN
dti-1305	631	15	.	.	PROPN
dti-1305	631	16	2001	2001	NUM
dti-1305	631	17	.	.	PUNCT
dti-1305	632	1	polyamines	polyamine	NOUN
dti-1305	632	2	with	with	ADP
dti-1305	632	3	n-(3	n-(3	NOUN
dti-1305	632	4	-	-	PUNCT
dti-1305	632	5	phenylpropyl	phenylpropyl	NOUN
dti-1305	632	6	)	)	PUNCT
dti-1305	632	7	substituents	substituent	NOUN
dti-1305	632	8	are	be	AUX
dti-1305	632	9	effective	effective	ADJ
dti-1305	632	10	competitive	competitive	ADJ
dti-1305	632	11	inhibitors	inhibitor	NOUN
dti-1305	632	12	of	of	ADP
dti-1305	632	13	trypanothione	trypanothione	NOUN
dti-1305	632	14	reductase	reductase	NOUN
dti-1305	632	15	and	and	CCONJ
dti-1305	632	16	trypanocidal	trypanocidal	ADJ
dti-1305	632	17	agents	agent	NOUN
dti-1305	632	18	.	.	PUNCT
dti-1305	633	1	bioorg	bioorg	PROPN
dti-1305	633	2	.	.	PUNCT
dti-1305	634	1	med	med	PROPN
dti-1305	634	2	.	.	PROPN
dti-1305	634	3	chem	chem	PROPN
dti-1305	634	4	.	.	PUNCT
dti-1305	635	1	lett	lett	PROPN
dti-1305	635	2	,	,	PUNCT
dti-1305	635	3	11:251–4	11:251–4	NUM
dti-1305	635	4	.	.	PUNCT
dti-1305	636	1	linares	linare	NOUN
dti-1305	636	2	,	,	PUNCT
dti-1305	636	3	g.e.g	g.e.g	PROPN
dti-1305	636	4	.	.	PROPN
dti-1305	636	5	,	,	PUNCT
dti-1305	636	6	ravaschino	ravaschino	PROPN
dti-1305	636	7	,	,	PUNCT
dti-1305	636	8	e.l	e.l	PROPN
dti-1305	636	9	.	.	PROPN
dti-1305	636	10	and	and	CCONJ
dti-1305	636	11	rodriguez	rodriguez	PROPN
dti-1305	636	12	,	,	PUNCT
dti-1305	636	13	j.b	j.b	PROPN
dti-1305	636	14	.	.	PROPN
dti-1305	636	15	2006	2006	NUM
dti-1305	636	16	.	.	PUNCT
dti-1305	637	1	progresses	progress	NOUN
dti-1305	637	2	in	in	ADP
dti-1305	637	3	the	the	DET
dti-1305	637	4	fi	fi	NOUN
dti-1305	637	5	eld	eld	NOUN
dti-1305	637	6	of	of	ADP
dti-1305	637	7	drug	drug	NOUN
dti-1305	637	8	design	design	NOUN
dti-1305	637	9	to	to	PART
dti-1305	637	10	combat	combat	VERB
dti-1305	637	11	tropical	tropical	ADJ
dti-1305	637	12	protozoan	protozoan	NOUN
dti-1305	637	13	parasitic	parasitic	ADJ
dti-1305	637	14	diseases	disease	NOUN
dti-1305	637	15	.	.	PUNCT
dti-1305	638	1	curr	curr	AUX
dti-1305	638	2	.	.	PUNCT
dti-1305	638	3	med	med	PROPN
dti-1305	638	4	.	.	PROPN
dti-1305	638	5	chem	chem	PROPN
dti-1305	638	6	.	.	PUNCT
dti-1305	638	7	,	,	PUNCT
dti-1305	639	1	13:335–60	13:335–60	NOUN
dti-1305	639	2	.	.	PUNCT
dti-1305	640	1	marsh	marsh	PROPN
dti-1305	640	2	,	,	PUNCT
dti-1305	640	3	i.r	i.r	PROPN
dti-1305	640	4	.	.	PROPN
dti-1305	640	5	and	and	CCONJ
dti-1305	640	6	bradley	bradley	PROPN
dti-1305	640	7	,	,	PUNCT
dti-1305	640	8	m.	m.	NOUN
dti-1305	640	9	1997	1997	NUM
dti-1305	640	10	.	.	PUNCT
dti-1305	641	1	substrate	substrate	NOUN
dti-1305	641	2	specifi	specifi	PROPN
dti-1305	641	3	city	city	PROPN
dti-1305	641	4	of	of	ADP
dti-1305	641	5	trypanothione	trypanothione	PROPN
dti-1305	641	6	reductase	reductase	NOUN
dti-1305	641	7	.	.	PUNCT
dti-1305	642	1	eur	eur	PROPN
dti-1305	642	2	.	.	PUNCT
dti-1305	643	1	j.	j.	PROPN
dti-1305	643	2	biochem	biochem	PROPN
dti-1305	643	3	.	.	PUNCT
dti-1305	643	4	,	,	PUNCT
dti-1305	644	1	243:690–4	243:690–4	X
dti-1305	644	2	.	.	PUNCT
dti-1305	644	3	maya	maya	PROPN
dti-1305	644	4	,	,	PUNCT
dti-1305	644	5	j.d	j.d	PROPN
dti-1305	644	6	.	.	PROPN
dti-1305	644	7	,	,	PUNCT
dti-1305	644	8	bollo	bollo	PROPN
dti-1305	644	9	,	,	PUNCT
dti-1305	644	10	s.	s.	PROPN
dti-1305	644	11	,	,	PUNCT
dti-1305	644	12	nunez	nunez	PROPN
dti-1305	644	13	-	-	PUNCT
dti-1305	644	14	vergara	vergara	PROPN
dti-1305	644	15	,	,	PUNCT
dti-1305	644	16	l.j	l.j	PROPN
dti-1305	644	17	.	.	PROPN
dti-1305	644	18	et	et	PROPN
dti-1305	644	19	al	al	PROPN
dti-1305	644	20	.	.	PROPN
dti-1305	644	21	2003	2003	NUM
dti-1305	644	22	.	.	PUNCT
dti-1305	645	1	trypanosoma	trypanosoma	PROPN
dti-1305	645	2	cruzi	cruzi	PROPN
dti-1305	645	3	:	:	PUNCT
dti-1305	645	4	effect	effect	NOUN
dti-1305	645	5	and	and	CCONJ
dti-1305	645	6	mode	mode	NOUN
dti-1305	645	7	of	of	ADP
dti-1305	645	8	action	action	NOUN
dti-1305	645	9	of	of	ADP
dti-1305	645	10	nitroimidazole	nitroimidazole	PROPN
dti-1305	645	11	and	and	CCONJ
dti-1305	645	12	nitrofuran	nitrofuran	NOUN
dti-1305	645	13	derivatives	derivative	NOUN
dti-1305	645	14	.	.	PUNCT
dti-1305	646	1	biochem	biochem	PROPN
dti-1305	646	2	.	.	PUNCT
dti-1305	647	1	pharmacol	pharmacol	PROPN
dti-1305	647	2	.	.	PROPN
dti-1305	647	3	,	,	PUNCT
dti-1305	648	1	65:999–1006	65:999–1006	NUM
dti-1305	648	2	.	.	PUNCT
dti-1305	649	1	mckie	mckie	PROPN
dti-1305	649	2	,	,	PUNCT
dti-1305	649	3	j.h	j.h	PROPN
dti-1305	649	4	.	.	PROPN
dti-1305	649	5	,	,	PUNCT
dti-1305	649	6	garforth	garforth	PROPN
dti-1305	649	7	,	,	PUNCT
dti-1305	649	8	j.	j.	PROPN
dti-1305	649	9	,	,	PUNCT
dti-1305	649	10	jaouhari	jaouhari	PROPN
dti-1305	649	11	,	,	PUNCT
dti-1305	649	12	r.	r.	PROPN
dti-1305	649	13	et	et	PROPN
dti-1305	649	14	al	al	PROPN
dti-1305	649	15	.	.	PROPN
dti-1305	649	16	2001	2001	NUM
dti-1305	649	17	.	.	PUNCT
dti-1305	650	1	specifi	specifi	PROPN
dti-1305	650	2	c	c	PROPN
dti-1305	650	3	peptide	peptide	NOUN
dti-1305	650	4	inhibitors	inhibitor	NOUN
dti-1305	650	5	of	of	ADP
dti-1305	650	6	trypanothione	trypanothione	NOUN
dti-1305	650	7	reductase	reductase	NOUN
dti-1305	650	8	with	with	ADP
dti-1305	650	9	backbone	backbone	NOUN
dti-1305	650	10	structures	structure	NOUN
dti-1305	650	11	unrelated	unrelated	ADJ
dti-1305	650	12	to	to	ADP
dti-1305	650	13	that	that	PRON
dti-1305	650	14	of	of	ADP
dti-1305	650	15	substrate	substrate	NOUN
dti-1305	650	16	:	:	PUNCT
dti-1305	650	17	potential	potential	ADJ
dti-1305	650	18	rational	rational	ADJ
dti-1305	650	19	drug	drug	NOUN
dti-1305	650	20	design	design	NOUN
dti-1305	650	21	lead	lead	NOUN
dti-1305	650	22	frameworks	framework	NOUN
dti-1305	650	23	.	.	PUNCT
dti-1305	651	1	amino	amino	NOUN
dti-1305	651	2	.	.	PUNCT
dti-1305	651	3	acids	acid	NOUN
dti-1305	651	4	,	,	PUNCT
dti-1305	651	5	20:145–53	20:145–53	NOUN
dti-1305	651	6	.	.	PUNCT
dti-1305	652	1	meshnick	meshnick	PROPN
dti-1305	652	2	,	,	PUNCT
dti-1305	652	3	s.r	s.r	PROPN
dti-1305	652	4	.	.	PROPN
dti-1305	652	5	,	,	PUNCT
dti-1305	652	6	1984	1984	NUM
dti-1305	652	7	.	.	PUNCT
dti-1305	653	1	parasitic	parasitic	ADJ
dti-1305	653	2	diseases	disease	NOUN
dti-1305	653	3	vol	vol	NOUN
dti-1305	653	4	2	2	NUM
dti-1305	653	5	.	.	PUNCT
dti-1305	653	6	mansfi	mansfi	PROPN
dti-1305	653	7	eld	eld	PROPN
dti-1305	653	8	jm	jm	PROPN
dti-1305	653	9	,	,	PUNCT
dti-1305	653	10	ed	ed	PROPN
dti-1305	653	11	.	.	PUNCT
dti-1305	654	1	new	new	PROPN
dti-1305	654	2	york	york	PROPN
dti-1305	654	3	:	:	PUNCT
dti-1305	654	4	marcel	marcel	PROPN
dti-1305	654	5	dekker	dekker	PROPN
dti-1305	654	6	.	.	PUNCT
dti-1305	655	1	michels	michels	PROPN
dti-1305	655	2	,	,	PUNCT
dti-1305	655	3	p.m.	p.m.	NOUN
dti-1305	655	4	,	,	PUNCT
dti-1305	655	5	1988	1988	NUM
dti-1305	655	6	.	.	PUNCT
dti-1305	656	1	compartmentation	compartmentation	NOUN
dti-1305	656	2	of	of	ADP
dti-1305	656	3	glycolysis	glycolysis	NOUN
dti-1305	656	4	in	in	ADP
dti-1305	656	5	trypanosomes	trypanosome	NOUN
dti-1305	656	6	:	:	PUNCT
dti-1305	656	7	a	a	DET
dti-1305	656	8	potential	potential	ADJ
dti-1305	656	9	target	target	NOUN
dti-1305	656	10	for	for	ADP
dti-1305	656	11	new	new	ADJ
dti-1305	656	12	trypanocidal	trypanocidal	ADJ
dti-1305	656	13	drugs	drug	NOUN
dti-1305	656	14	.	.	PUNCT
dti-1305	657	1	biol	biol	PROPN
dti-1305	657	2	.	.	PUNCT
dti-1305	658	1	cell	cell	NOUN
dti-1305	658	2	.	.	PUNCT
dti-1305	658	3	,	,	PUNCT
dti-1305	658	4	64:157–64	64:157–64	PROPN
dti-1305	658	5	.	.	PUNCT
dti-1305	659	1	neva	neva	PROPN
dti-1305	659	2	,	,	PUNCT
dti-1305	659	3	f.a	f.a	PROPN
dti-1305	659	4	.	.	PROPN
dti-1305	659	5	and	and	CCONJ
dti-1305	659	6	brown	brown	PROPN
dti-1305	659	7	,	,	PUNCT
dti-1305	659	8	h.w	h.w	PROPN
dti-1305	659	9	.	.	PROPN
dti-1305	659	10	,	,	PUNCT
dti-1305	659	11	1994	1994	NUM
dti-1305	659	12	.	.	PUNCT
dti-1305	660	1	basic	basic	ADJ
dti-1305	660	2	clinical	clinical	ADJ
dti-1305	660	3	parasitology	parasitology	NOUN
dti-1305	660	4	.	.	PUNCT
dti-1305	661	1	norwalk	norwalk	PROPN
dti-1305	661	2	,	,	PUNCT
dti-1305	661	3	connecticut	connecticut	PROPN
dti-1305	661	4	:	:	PUNCT
dti-1305	661	5	appleton	appleton	PROPN
dti-1305	661	6	&	&	CCONJ
dti-1305	661	7	lange	lange	PROPN
dti-1305	661	8	.	.	PUNCT
dti-1305	662	1	nogoceke	nogoceke	PROPN
dti-1305	662	2	,	,	PUNCT
dti-1305	662	3	e.	e.	PROPN
dti-1305	662	4	,	,	PUNCT
dti-1305	662	5	gommel	gommel	PROPN
dti-1305	662	6	,	,	PUNCT
dti-1305	662	7	d.u	d.u	PROPN
dti-1305	662	8	.	.	PROPN
dti-1305	662	9	,	,	PUNCT
dti-1305	662	10	kiess	kiess	PROPN
dti-1305	662	11	,	,	PUNCT
dti-1305	662	12	m.	m.	NOUN
dti-1305	662	13	et	et	PROPN
dti-1305	662	14	al	al	PROPN
dti-1305	662	15	.	.	PROPN
dti-1305	662	16	1997	1997	NUM
dti-1305	662	17	.	.	PUNCT
dti-1305	663	1	a	a	DET
dti-1305	663	2	unique	unique	ADJ
dti-1305	663	3	cascade	cascade	NOUN
dti-1305	663	4	of	of	ADP
dti-1305	663	5	oxidoreductases	oxidoreductase	NOUN
dti-1305	663	6	catalyses	catalyse	VERB
dti-1305	663	7	trypanothione	trypanothione	NOUN
dti-1305	663	8	-	-	PUNCT
dti-1305	663	9	mediated	mediate	VERB
dti-1305	663	10	peroxide	peroxide	NOUN
dti-1305	663	11	metabolism	metabolism	NOUN
dti-1305	663	12	in	in	ADP
dti-1305	663	13	crithidia	crithidia	NOUN
dti-1305	663	14	fasciculata	fasciculata	NOUN
dti-1305	663	15	.	.	PUNCT
dti-1305	664	1	biol	biol	PROPN
dti-1305	664	2	.	.	PUNCT
dti-1305	665	1	chem	chem	PROPN
dti-1305	665	2	.	.	PUNCT
dti-1305	665	3	,	,	PUNCT
dti-1305	666	1	378:827–36	378:827–36	NUM
dti-1305	666	2	.	.	PUNCT
dti-1305	667	1	ogston	ogston	PROPN
dti-1305	667	2	,	,	PUNCT
dti-1305	667	3	a.g	a.g	PROPN
dti-1305	667	4	,	,	PUNCT
dti-1305	667	5	1948	1948	NUM
dti-1305	667	6	.	.	PUNCT
dti-1305	668	1	interpretation	interpretation	NOUN
dti-1305	668	2	of	of	ADP
dti-1305	668	3	experiments	experiment	NOUN
dti-1305	668	4	on	on	ADP
dti-1305	668	5	metabolic	metabolic	NOUN
dti-1305	668	6	processes	process	NOUN
dti-1305	668	7	,	,	PUNCT
dti-1305	668	8	using	use	VERB
dti-1305	668	9	isotopic	isotopic	ADJ
dti-1305	668	10	tracer	tracer	NOUN
dti-1305	668	11	elements	element	NOUN
dti-1305	668	12	.	.	PUNCT
dti-1305	669	1	nature	nature	NOUN
dti-1305	669	2	,	,	PUNCT
dti-1305	669	3	162:963	162:963	NUM
dti-1305	669	4	.	.	PUNCT
dti-1305	670	1	orain	orain	PROPN
dti-1305	670	2	,	,	PUNCT
dti-1305	670	3	d.	d.	PROPN
dti-1305	670	4	and	and	CCONJ
dti-1305	670	5	bradley	bradley	PROPN
dti-1305	670	6	,	,	PUNCT
dti-1305	670	7	m.	m.	NOUN
dti-1305	670	8	2001	2001	NUM
dti-1305	670	9	.	.	PUNCT
dti-1305	671	1	solid	solid	ADJ
dti-1305	671	2	phase	phase	NOUN
dti-1305	671	3	synthesis	synthesis	NOUN
dti-1305	671	4	of	of	ADP
dti-1305	671	5	trypanothione	trypanothione	ADJ
dti-1305	671	6	reductase	reductase	NOUN
dti-1305	671	7	inhibitors	inhibitor	NOUN
dti-1305	671	8	—	—	PUNCT
dti-1305	671	9	towards	towards	ADP
dti-1305	671	10	single	single	ADJ
dti-1305	671	11	bead	bead	NOUN
dti-1305	671	12	screening	screen	VERB
dti-1305	671	13	.	.	PUNCT
dti-1305	672	1	tet	tet	NOUN
dti-1305	672	2	lett	lett	PROPN
dti-1305	672	3	,	,	PUNCT
dti-1305	672	4	42:515–8	42:515–8	NUM
dti-1305	672	5	.	.	PUNCT
dti-1305	673	1	o’sullivan	o’sullivan	PROPN
dti-1305	673	2	,	,	PUNCT
dti-1305	673	3	m.c	m.c	PROPN
dti-1305	673	4	.	.	PROPN
dti-1305	673	5	and	and	CCONJ
dti-1305	673	6	zhou	zhou	PROPN
dti-1305	673	7	,	,	PUNCT
dti-1305	673	8	q.	q.	PROPN
dti-1305	673	9	1995	1995	NUM
dti-1305	673	10	.	.	PUNCT
dti-1305	674	1	novel	novel	ADJ
dti-1305	674	2	polyamine	polyamine	NOUN
dti-1305	674	3	derivatives	derivative	NOUN
dti-1305	674	4	as	as	ADP
dti-1305	674	5	potent	potent	ADJ
dti-1305	674	6	competitive	competitive	ADJ
dti-1305	674	7	inhibitors	inhibitor	NOUN
dti-1305	674	8	of	of	ADP
dti-1305	674	9	trypanosoma	trypanosoma	NOUN
dti-1305	674	10	cruzi	cruzi	PROPN
dti-1305	674	11	trypanothione	trypanothione	PROPN
dti-1305	674	12	reductase	reductase	NOUN
dti-1305	674	13	.	.	PUNCT
dti-1305	675	1	bioorg	bioorg	PROPN
dti-1305	675	2	.	.	PUNCT
dti-1305	676	1	med	med	PROPN
dti-1305	676	2	.	.	PROPN
dti-1305	676	3	chem	chem	PROPN
dti-1305	676	4	.	.	PUNCT
dti-1305	677	1	lett	lett	PROPN
dti-1305	677	2	.	.	PROPN
dti-1305	677	3	,	,	PUNCT
dti-1305	677	4	5:1957–60	5:1957–60	PROPN
dti-1305	677	5	.	.	PUNCT
dti-1305	678	1	o’sullivan	o’sullivan	PROPN
dti-1305	678	2	,	,	PUNCT
dti-1305	678	3	m.c	m.c	PROPN
dti-1305	678	4	.	.	PROPN
dti-1305	678	5	,	,	PUNCT
dti-1305	678	6	dalrymple	dalrymple	PROPN
dti-1305	678	7	,	,	PUNCT
dti-1305	678	8	d.m	d.m	PROPN
dti-1305	678	9	.	.	PROPN
dti-1305	679	1	and	and	CCONJ
dti-1305	679	2	zhou	zhou	PROPN
dti-1305	679	3	,	,	PUNCT
dti-1305	679	4	q.	q.	PROPN
dti-1305	679	5	1996	1996	NUM
dti-1305	679	6	.	.	PUNCT
dti-1305	680	1	inhibiting	inhibit	VERB
dti-1305	680	2	effects	effect	NOUN
dti-1305	680	3	of	of	ADP
dti-1305	680	4	spermidine	spermidine	NOUN
dti-1305	680	5	derivatives	derivative	NOUN
dti-1305	680	6	on	on	ADP
dti-1305	680	7	trypanosoma	trypanosoma	PROPN
dti-1305	680	8	cruzi	cruzi	PROPN
dti-1305	680	9	trypanothione	trypanothione	PROPN
dti-1305	680	10	reductase	reductase	NOUN
dti-1305	680	11	.	.	PUNCT
dti-1305	681	1	j.	j.	PROPN
dti-1305	681	2	enz	enz	PROPN
dti-1305	681	3	.	.	PROPN
dti-1305	681	4	inhibition	inhibition	PROPN
dti-1305	681	5	.	.	PUNCT
dti-1305	681	6	,	,	PUNCT
dti-1305	681	7	11:97–114	11:97–114	NUM
dti-1305	681	8	.	.	PUNCT
dti-1305	682	1	o’sullivan	o’sullivan	PROPN
dti-1305	682	2	,	,	PUNCT
dti-1305	682	3	m.c	m.c	PROPN
dti-1305	682	4	.	.	PROPN
dti-1305	682	5	,	,	PUNCT
dti-1305	682	6	zhou	zhou	PROPN
dti-1305	682	7	,	,	PUNCT
dti-1305	682	8	q.	q.	PROPN
dti-1305	682	9	,	,	PUNCT
dti-1305	682	10	li	li	PROPN
dti-1305	682	11	,	,	PUNCT
dti-1305	682	12	z.	z.	PROPN
dti-1305	682	13	et	et	PROPN
dti-1305	682	14	al	al	PROPN
dti-1305	682	15	.	.	PROPN
dti-1305	682	16	1997	1997	NUM
dti-1305	682	17	.	.	PUNCT
dti-1305	683	1	polyamine	polyamine	NOUN
dti-1305	683	2	derivatives	derivative	NOUN
dti-1305	683	3	as	as	ADP
dti-1305	683	4	inhibitors	inhibitor	NOUN
dti-1305	683	5	of	of	ADP
dti-1305	683	6	trypanothione	trypanothione	NOUN
dti-1305	683	7	reductase	reductase	NOUN
dti-1305	683	8	and	and	CCONJ
dti-1305	683	9	assessment	assessment	NOUN
dti-1305	683	10	of	of	ADP
dti-1305	683	11	their	their	PRON
dti-1305	683	12	trypanocidal	trypanocidal	ADJ
dti-1305	683	13	activities	activity	NOUN
dti-1305	683	14	.	.	PUNCT
dti-1305	684	1	bioorg	bioorg	VERB
dti-1305	684	2	.	.	PUNCT
dti-1305	685	1	med	med	PROPN
dti-1305	685	2	.	.	PROPN
dti-1305	685	3	chem	chem	PROPN
dti-1305	685	4	.	.	PUNCT
dti-1305	685	5	,	,	PUNCT
dti-1305	685	6	5:2145–55	5:2145–55	NUM
dti-1305	685	7	.	.	PUNCT
dti-1305	686	1	otero	otero	PROPN
dti-1305	686	2	,	,	PUNCT
dti-1305	686	3	l.	l.	PROPN
dti-1305	686	4	,	,	PUNCT
dti-1305	686	5	vieites	vieite	NOUN
dti-1305	686	6	,	,	PUNCT
dti-1305	686	7	m.	m.	NOUN
dti-1305	686	8	,	,	PUNCT
dti-1305	686	9	boiani	boiani	PROPN
dti-1305	686	10	,	,	PUNCT
dti-1305	686	11	l.	l.	PROPN
dti-1305	686	12	et	et	PROPN
dti-1305	686	13	al	al	PROPN
dti-1305	686	14	.	.	PROPN
dti-1305	686	15	2006	2006	NUM
dti-1305	686	16	.	.	PUNCT
dti-1305	687	1	novel	novel	ADJ
dti-1305	687	2	antitrypanosomal	antitrypanosomal	ADJ
dti-1305	687	3	agents	agent	NOUN
dti-1305	687	4	based	base	VERB
dti-1305	687	5	on	on	ADP
dti-1305	687	6	palladium	palladium	NOUN
dti-1305	687	7	nitrofurylthiosemicarbazone	nitrofurylthiosemicarbazone	NOUN
dti-1305	687	8	complexes	complex	NOUN
dti-1305	687	9	:	:	PUNCT
dti-1305	687	10	dna	dna	NOUN
dti-1305	687	11	and	and	CCONJ
dti-1305	687	12	redox	redox	ADJ
dti-1305	687	13	metabolism	metabolism	NOUN
dti-1305	687	14	as	as	ADP
dti-1305	687	15	potential	potential	ADJ
dti-1305	687	16	therapeutic	therapeutic	ADJ
dti-1305	687	17	targets	target	NOUN
dti-1305	687	18	.	.	PUNCT
dti-1305	688	1	j.	j.	PROPN
dti-1305	688	2	med	med	PROPN
dti-1305	688	3	.	.	PROPN
dti-1305	688	4	chem	chem	PROPN
dti-1305	688	5	.	.	PUNCT
dti-1305	688	6	,	,	PUNCT
dti-1305	689	1	49:3322–31	49:3322–31	PROPN
dti-1305	689	2	.	.	PUNCT
dti-1305	689	3	parveen	parveen	PROPN
dti-1305	689	4	,	,	PUNCT
dti-1305	689	5	s.	s.	PROPN
dti-1305	689	6	,	,	PUNCT
dti-1305	689	7	khan	khan	PROPN
dti-1305	689	8	,	,	PUNCT
dti-1305	689	9	m.o.f	m.o.f	ADJ
dti-1305	689	10	.	.	PROPN
dti-1305	689	11	,	,	PUNCT
dti-1305	689	12	austin	austin	PROPN
dti-1305	689	13	,	,	PUNCT
dti-1305	689	14	s.e	s.e	PROPN
dti-1305	689	15	.	.	PROPN
dti-1305	689	16	et	et	PROPN
dti-1305	689	17	al	al	PROPN
dti-1305	689	18	.	.	PROPN
dti-1305	689	19	2005	2005	NUM
dti-1305	689	20	.	.	PUNCT
dti-1305	690	1	anti	anti	ADJ
dti-1305	690	2	-	-	ADJ
dti-1305	690	3	trypanosomal	trypanosomal	ADJ
dti-1305	690	4	,	,	PUNCT
dti-1305	690	5	anti	anti	ADJ
dti-1305	690	6	-	-	ADJ
dti-1305	690	7	leishmanial	leishmanial	ADJ
dti-1305	690	8	and	and	CCONJ
dti-1305	690	9	anti	anti	ADJ
dti-1305	690	10	-	-	ADJ
dti-1305	690	11	malarial	malarial	ADJ
dti-1305	690	12	activities	activity	NOUN
dti-1305	690	13	of	of	ADP
dti-1305	690	14	quaternary	quaternary	ADJ
dti-1305	690	15	arylalkylammonium	arylalkylammonium	NOUN
dti-1305	690	16	2	2	NUM
dti-1305	690	17	-	-	PUNCT
dti-1305	690	18	amino-4	amino-4	NOUN
dti-1305	690	19	-	-	PUNCT
dti-1305	690	20	chlorophenyl	chlorophenyl	NOUN
dti-1305	690	21	phenyl	phenyl	NOUN
dti-1305	690	22	sulfi	sulfi	NOUN
dti-1305	690	23	des	des	PROPN
dti-1305	690	24	,	,	PUNCT
dti-1305	690	25	a	a	DET
dti-1305	690	26	new	new	ADJ
dti-1305	690	27	class	class	NOUN
dti-1305	690	28	of	of	ADP
dti-1305	690	29	trypanothione	trypanothione	NOUN
dti-1305	690	30	reductase	reductase	NOUN
dti-1305	690	31	inhibitor	inhibitor	NOUN
dti-1305	690	32	,	,	PUNCT
dti-1305	690	33	and	and	CCONJ
dti-1305	690	34	of	of	ADP
dti-1305	690	35	n	n	CCONJ
dti-1305	690	36	-	-	PUNCT
dti-1305	690	37	acyl	acyl	ADJ
dti-1305	690	38	derivatives	derivative	NOUN
dti-1305	690	39	of	of	ADP
dti-1305	690	40	2amino-4	2amino-4	NUM
dti-1305	690	41	-	-	PUNCT
dti-1305	690	42	chlorophenyl	chlorophenyl	NOUN
dti-1305	690	43	phenyl	phenyl	NOUN
dti-1305	690	44	sulfi	sulfi	NOUN
dti-1305	690	45	de	de	PROPN
dti-1305	690	46	.	.	PROPN
dti-1305	690	47	j.	j.	PROPN
dti-1305	690	48	med	med	PROPN
dti-1305	690	49	.	.	PROPN
dti-1305	690	50	chem	chem	PROPN
dti-1305	690	51	.	.	PUNCT
dti-1305	690	52	,	,	PUNCT
dti-1305	691	1	48:8087–97	48:8087–97	NUM
dti-1305	691	2	.	.	PUNCT
dti-1305	691	3	ponasik	ponasik	NOUN
dti-1305	691	4	,	,	PUNCT
dti-1305	691	5	j.a	j.a	PROPN
dti-1305	691	6	.	.	PROPN
dti-1305	691	7	,	,	PUNCT
dti-1305	691	8	strickland	strickland	PROPN
dti-1305	691	9	,	,	PUNCT
dti-1305	691	10	c.	c.	PROPN
dti-1305	691	11	,	,	PUNCT
dti-1305	691	12	faerman	faerman	NOUN
dti-1305	691	13	,	,	PUNCT
dti-1305	691	14	c.	c.	PROPN
dti-1305	691	15	et	et	PROPN
dti-1305	691	16	al	al	PROPN
dti-1305	691	17	.	.	PROPN
dti-1305	691	18	1995	1995	NUM
dti-1305	691	19	.	.	PUNCT
dti-1305	692	1	kukoamine	kukoamine	PROPN
dti-1305	692	2	a	a	DET
dti-1305	692	3	and	and	CCONJ
dti-1305	692	4	other	other	ADJ
dti-1305	692	5	hydrophobic	hydrophobic	ADJ
dti-1305	692	6	acylpolyamines	acylpolyamine	NOUN
dti-1305	692	7	:	:	PUNCT
dti-1305	692	8	potent	potent	ADJ
dti-1305	692	9	and	and	CCONJ
dti-1305	692	10	selective	selective	ADJ
dti-1305	692	11	inhibitors	inhibitor	NOUN
dti-1305	692	12	of	of	ADP
dti-1305	692	13	crithidia	crithidia	NOUN
dti-1305	692	14	fasciculata	fasciculata	NOUN
dti-1305	692	15	trypanothione	trypanothione	PROPN
dti-1305	692	16	reductase	reductase	NOUN
dti-1305	692	17	.	.	PUNCT
dti-1305	693	1	biochem	biochem	PROPN
dti-1305	693	2	.	.	PUNCT
dti-1305	694	1	j.	j.	PROPN
dti-1305	694	2	,	,	PUNCT
dti-1305	694	3	311:371–5	311:371–5	PROPN
dti-1305	694	4	.	.	PUNCT
dti-1305	695	1	rivarola	rivarola	PROPN
dti-1305	695	2	,	,	PUNCT
dti-1305	695	3	h.w	h.w	PROPN
dti-1305	695	4	.	.	PROPN
dti-1305	695	5	,	,	PUNCT
dti-1305	695	6	fernandez	fernandez	PROPN
dti-1305	695	7	,	,	PUNCT
dti-1305	695	8	a.r	a.r	PROPN
dti-1305	695	9	.	.	PROPN
dti-1305	695	10	,	,	PUNCT
dti-1305	695	11	enders	ender	NOUN
dti-1305	695	12	,	,	PUNCT
dti-1305	695	13	j.e	j.e	PROPN
dti-1305	695	14	.	.	PROPN
dti-1305	695	15	et	et	PROPN
dti-1305	695	16	al	al	PROPN
dti-1305	695	17	.	.	PROPN
dti-1305	695	18	2001	2001	NUM
dti-1305	695	19	.	.	PUNCT
dti-1305	696	1	effects	effect	NOUN
dti-1305	696	2	of	of	ADP
dti-1305	696	3	clomipramine	clomipramine	NOUN
dti-1305	696	4	on	on	ADP
dti-1305	696	5	trypanosoma	trypanosoma	PROPN
dti-1305	696	6	cruzi	cruzi	PROPN
dti-1305	696	7	infection	infection	NOUN
dti-1305	696	8	in	in	ADP
dti-1305	696	9	mice	mouse	NOUN
dti-1305	696	10	.	.	PUNCT
dti-1305	697	1	trans	tran	NOUN
dti-1305	697	2	.	.	PUNCT
dti-1305	698	1	royal	royal	PROPN
dti-1305	698	2	.	.	PUNCT
dti-1305	698	3	soc	soc	PROPN
dti-1305	698	4	.	.	PUNCT
dti-1305	699	1	trop	trop	X
dti-1305	699	2	.	.	PUNCT
dti-1305	699	3	med	med	PROPN
dti-1305	699	4	.	.	PUNCT
dti-1305	700	1	hyg	hyg	PROPN
dti-1305	700	2	.	.	PROPN
dti-1305	700	3	,	,	PUNCT
dti-1305	700	4	95:529–33	95:529–33	PROPN
dti-1305	700	5	.	.	PUNCT
dti-1305	701	1	rivarola	rivarola	PROPN
dti-1305	701	2	,	,	PUNCT
dti-1305	701	3	h.w	h.w	PROPN
dti-1305	701	4	.	.	PROPN
dti-1305	701	5	and	and	CCONJ
dti-1305	701	6	paglini	paglini	PROPN
dti-1305	701	7	-	-	ADJ
dti-1305	701	8	oliva	oliva	PROPN
dti-1305	701	9	,	,	PUNCT
dti-1305	701	10	p.a	p.a	PROPN
dti-1305	701	11	.	.	PROPN
dti-1305	701	12	2002	2002	NUM
dti-1305	701	13	.	.	PUNCT
dti-1305	702	1	trypanosoma	trypanosoma	PROPN
dti-1305	702	2	cruzi	cruzi	PROPN
dti-1305	702	3	trypanothione	trypanothione	PROPN
dti-1305	702	4	reductase	reductase	NOUN
dti-1305	702	5	inhibitors	inhibitor	NOUN
dti-1305	702	6	:	:	PUNCT
dti-1305	702	7	phenothiazines	phenothiazine	NOUN
dti-1305	702	8	and	and	CCONJ
dti-1305	702	9	related	related	ADJ
dti-1305	702	10	compounds	compound	NOUN
dti-1305	702	11	modify	modify	VERB
dti-1305	702	12	experimental	experimental	ADJ
dti-1305	702	13	chagas	chagas	NOUN
dti-1305	702	14	’	'	PUNCT
dti-1305	702	15	disease	disease	NOUN
dti-1305	702	16	evolution	evolution	NOUN
dti-1305	702	17	.	.	PUNCT
dti-1305	703	1	curr	curr	PROPN
dti-1305	703	2	drug	drug	NOUN
dti-1305	703	3	targets	target	NOUN
dti-1305	703	4	:	:	PUNCT
dti-1305	703	5	cardiovasc	cardiovasc	PROPN
dti-1305	703	6	.	.	PUNCT
dti-1305	704	1	haematol	haematol	PROPN
dti-1305	704	2	.	.	PUNCT
dti-1305	705	1	disord	disord	PROPN
dti-1305	705	2	.	.	PUNCT
dti-1305	705	3	,	,	PUNCT
dti-1305	705	4	2:43–52	2:43–52	NUM
dti-1305	705	5	.	.	PUNCT
dti-1305	706	1	salmon	salmon	NOUN
dti-1305	706	2	-	-	PUNCT
dti-1305	706	3	chemin	chemin	PROPN
dti-1305	706	4	,	,	PUNCT
dti-1305	706	5	l.	l.	PROPN
dti-1305	706	6	,	,	PUNCT
dti-1305	706	7	buisine	buisine	PROPN
dti-1305	706	8	,	,	PUNCT
dti-1305	706	9	e.	e.	PROPN
dti-1305	706	10	,	,	PUNCT
dti-1305	706	11	yardley	yardley	PROPN
dti-1305	706	12	,	,	PUNCT
dti-1305	706	13	v.	v.	ADP
dti-1305	706	14	et	et	PROPN
dti-1305	706	15	al	al	PROPN
dti-1305	706	16	.	.	PROPN
dti-1305	706	17	2001	2001	NUM
dti-1305	706	18	.	.	PUNCT
dti-1305	707	1	2and	2and	NUM
dti-1305	707	2	3	3	NUM
dti-1305	707	3	-	-	PUNCT
dti-1305	707	4	substituted	substitute	VERB
dti-1305	707	5	1,4	1,4	NUM
dti-1305	707	6	-	-	PUNCT
dti-1305	707	7	naphthoquinone	naphthoquinone	ADJ
dti-1305	707	8	derivatives	derivative	NOUN
dti-1305	707	9	as	as	ADP
dti-1305	707	10	subversive	subversive	ADJ
dti-1305	707	11	substrates	substrate	NOUN
dti-1305	707	12	of	of	ADP
dti-1305	707	13	trypanothione	trypanothione	NOUN
dti-1305	707	14	reductase	reductase	NOUN
dti-1305	707	15	and	and	CCONJ
dti-1305	707	16	lipoamide	lipoamide	ADJ
dti-1305	707	17	dehydrogenase	dehydrogenase	NOUN
dti-1305	707	18	from	from	ADP
dti-1305	707	19	trypanosoma	trypanosoma	PROPN
dti-1305	707	20	cruzi	cruzi	PROPN
dti-1305	707	21	:	:	PUNCT
dti-1305	707	22	synthesis	synthesis	NOUN
dti-1305	707	23	and	and	CCONJ
dti-1305	707	24	correlation	correlation	NOUN
dti-1305	707	25	between	between	ADP
dti-1305	707	26	redox	redox	ADJ
dti-1305	707	27	cycling	cycling	NOUN
dti-1305	707	28	activities	activity	NOUN
dti-1305	707	29	and	and	CCONJ
dti-1305	707	30	in	in	ADP
dti-1305	707	31	vitro	vitro	X
dti-1305	707	32	cytotoxicity	cytotoxicity	NOUN
dti-1305	707	33	.	.	PUNCT
dti-1305	708	1	j.	j.	PROPN
dti-1305	708	2	med	med	PROPN
dti-1305	708	3	.	.	PROPN
dti-1305	708	4	chem	chem	PROPN
dti-1305	708	5	.	.	PUNCT
dti-1305	708	6	,	,	PUNCT
dti-1305	708	7	44:548–65	44:548–65	PROPN
dti-1305	708	8	.	.	PUNCT
dti-1305	709	1	drug	drug	NOUN
dti-1305	709	2	target	target	NOUN
dti-1305	709	3	insights	insight	NOUN
dti-1305	709	4	2007	2007	NUM
dti-1305	709	5	:	:	PUNCT
dti-1305	709	6	2	2	NUM
dti-1305	709	7	146	146	NUM
dti-1305	709	8	khan	khan	PROPN
dti-1305	709	9	saravanamuthu	saravanamuthu	PROPN
dti-1305	709	10	,	,	PUNCT
dti-1305	709	11	a.	a.	NOUN
dti-1305	709	12	,	,	PUNCT
dti-1305	709	13	vickers	vickers	PROPN
dti-1305	709	14	,	,	PUNCT
dti-1305	709	15	t.j	t.j	PROPN
dti-1305	709	16	.	.	PROPN
dti-1305	709	17	,	,	PUNCT
dti-1305	709	18	bond	bond	PROPN
dti-1305	709	19	,	,	PUNCT
dti-1305	709	20	c.s	c.s	PROPN
dti-1305	709	21	.	.	PROPN
dti-1305	709	22	et	et	PROPN
dti-1305	709	23	al	al	PROPN
dti-1305	709	24	.	.	PROPN
dti-1305	709	25	2004	2004	NUM
dti-1305	709	26	.	.	PUNCT
dti-1305	710	1	two	two	NUM
dti-1305	710	2	interacting	interact	VERB
dti-1305	710	3	binding	bind	VERB
dti-1305	710	4	sites	site	NOUN
dti-1305	710	5	for	for	ADP
dti-1305	710	6	quinacrine	quinacrine	ADJ
dti-1305	710	7	derivatives	derivative	NOUN
dti-1305	710	8	in	in	ADP
dti-1305	710	9	the	the	DET
dti-1305	710	10	active	active	ADJ
dti-1305	710	11	site	site	NOUN
dti-1305	710	12	of	of	ADP
dti-1305	710	13	trypanothione	trypanothione	PROPN
dti-1305	710	14	reductase	reductase	NOUN
dti-1305	710	15	:	:	PUNCT
dti-1305	710	16	a	a	DET
dti-1305	710	17	template	template	NOUN
dti-1305	710	18	for	for	ADP
dti-1305	710	19	drug	drug	NOUN
dti-1305	710	20	design	design	NOUN
dti-1305	710	21	.	.	PUNCT
dti-1305	711	1	j.	j.	PROPN
dti-1305	711	2	biol	biol	PROPN
dti-1305	711	3	.	.	PUNCT
dti-1305	712	1	chem	chem	PROPN
dti-1305	712	2	.	.	PUNCT
dti-1305	712	3	,	,	PUNCT
dti-1305	712	4	279:29493–500	279:29493–500	NOUN
dti-1305	712	5	.	.	PUNCT
dti-1305	713	1	schirmer	schirmer	PROPN
dti-1305	713	2	,	,	PUNCT
dti-1305	713	3	r.h	r.h	PROPN
dti-1305	713	4	.	.	PROPN
dti-1305	713	5	,	,	PUNCT
dti-1305	713	6	mueller	mueller	PROPN
dti-1305	713	7	,	,	PUNCT
dti-1305	713	8	j.g	j.g	PROPN
dti-1305	713	9	.	.	PROPN
dti-1305	713	10	,	,	PUNCT
dti-1305	713	11	krauth	krauth	NOUN
dti-1305	713	12	-	-	PUNCT
dti-1305	713	13	siegel	siegel	PROPN
dti-1305	713	14	,	,	PUNCT
dti-1305	713	15	r.l	r.l	PROPN
dti-1305	713	16	.	.	PROPN
dti-1305	713	17	,	,	PUNCT
dti-1305	713	18	1995	1995	NUM
dti-1305	713	19	.	.	PUNCT
dti-1305	714	1	disulfi	disulfi	PROPN
dti-1305	714	2	de	de	ADJ
dti-1305	714	3	-	-	NOUN
dti-1305	714	4	reductase	reductase	NOUN
dti-1305	714	5	inhibitors	inhibitor	NOUN
dti-1305	714	6	as	as	ADP
dti-1305	714	7	chemotherapeutic	chemotherapeutic	ADJ
dti-1305	714	8	agents	agent	NOUN
dti-1305	714	9	:	:	PUNCT
dti-1305	714	10	the	the	DET
dti-1305	714	11	design	design	NOUN
dti-1305	714	12	of	of	ADP
dti-1305	714	13	drugs	drug	NOUN
dti-1305	714	14	for	for	ADP
dti-1305	714	15	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	714	16	and	and	CCONJ
dti-1305	714	17	malaria	malaria	NOUN
dti-1305	714	18	.	.	PUNCT
dti-1305	715	1	angew	angew	PROPN
dti-1305	715	2	.	.	PUNCT
dti-1305	716	1	chem	chem	PROPN
dti-1305	716	2	.	.	PUNCT
dti-1305	717	1	int	int	NOUN
dti-1305	717	2	.	.	PUNCT
dti-1305	718	1	ed	ed	NOUN
dti-1305	718	2	,	,	PUNCT
dti-1305	718	3	34:141–54	34:141–54	NUM
dti-1305	718	4	.	.	PUNCT
dti-1305	719	1	shames	shame	VERB
dti-1305	719	2	,	,	PUNCT
dti-1305	719	3	s.l	s.l	PROPN
dti-1305	719	4	.	.	PROPN
dti-1305	719	5	,	,	PUNCT
dti-1305	719	6	fairlamb	fairlamb	PROPN
dti-1305	719	7	,	,	PUNCT
dti-1305	719	8	a.h	a.h	PROPN
dti-1305	719	9	.	.	PROPN
dti-1305	719	10	,	,	PUNCT
dti-1305	719	11	cerami	cerami	PROPN
dti-1305	719	12	,	,	PUNCT
dti-1305	719	13	a.	a.	PROPN
dti-1305	719	14	et	et	PROPN
dti-1305	719	15	al	al	PROPN
dti-1305	719	16	.	.	PROPN
dti-1305	719	17	1986	1986	NUM
dti-1305	719	18	.	.	PUNCT
dti-1305	720	1	purifi	purifi	ADJ
dti-1305	720	2	cation	cation	NOUN
dti-1305	720	3	and	and	CCONJ
dti-1305	720	4	characterization	characterization	NOUN
dti-1305	720	5	of	of	ADP
dti-1305	720	6	trypanothione	trypanothione	NOUN
dti-1305	720	7	reductase	reductase	NOUN
dti-1305	720	8	from	from	ADP
dti-1305	720	9	crithidia	crithidia	PROPN
dti-1305	720	10	fasciculata	fasciculata	NOUN
dti-1305	720	11	,	,	PUNCT
dti-1305	720	12	a	a	DET
dti-1305	720	13	newly	newly	ADV
dti-1305	720	14	discovered	discover	VERB
dti-1305	720	15	member	member	NOUN
dti-1305	720	16	of	of	ADP
dti-1305	720	17	the	the	DET
dti-1305	720	18	family	family	NOUN
dti-1305	720	19	of	of	ADP
dti-1305	720	20	disulfi	disulfi	PROPN
dti-1305	720	21	de	de	X
dti-1305	720	22	-	-	VERB
dti-1305	720	23	containing	contain	VERB
dti-1305	720	24	fl	fl	PROPN
dti-1305	720	25	avoprotein	avoprotein	PROPN
dti-1305	720	26	reductases	reductase	NOUN
dti-1305	720	27	.	.	PUNCT
dti-1305	721	1	biochemistry	biochemistry	NOUN
dti-1305	721	2	,	,	PUNCT
dti-1305	721	3	25:3519–26	25:3519–26	NUM
dti-1305	721	4	.	.	PUNCT
dti-1305	722	1	shapiro	shapiro	PROPN
dti-1305	722	2	,	,	PUNCT
dti-1305	722	3	t.a	t.a	PROPN
dti-1305	722	4	.	.	PROPN
dti-1305	722	5	,	,	PUNCT
dti-1305	722	6	1993	1993	NUM
dti-1305	722	7	.	.	PUNCT
dti-1305	723	1	inhibition	inhibition	NOUN
dti-1305	723	2	of	of	ADP
dti-1305	723	3	topoisomerases	topoisomerase	NOUN
dti-1305	723	4	in	in	ADP
dti-1305	723	5	african	african	ADJ
dti-1305	723	6	trypanosomes	trypanosome	NOUN
dti-1305	723	7	.	.	PUNCT
dti-1305	724	1	acta	acta	PROPN
dti-1305	724	2	tropica	tropica	PROPN
dti-1305	724	3	,	,	PUNCT
dti-1305	724	4	54:251–60	54:251–60	NOUN
dti-1305	724	5	.	.	PUNCT
dti-1305	725	1	shapiro	shapiro	PROPN
dti-1305	725	2	,	,	PUNCT
dti-1305	725	3	t.a	t.a	PROPN
dti-1305	725	4	.	.	PROPN
dti-1305	725	5	and	and	CCONJ
dti-1305	725	6	showalter	showalter	PROPN
dti-1305	725	7	,	,	PUNCT
dti-1305	725	8	a.f	a.f	PROPN
dti-1305	725	9	.	.	PROPN
dti-1305	725	10	1994	1994	NUM
dti-1305	725	11	.	.	PUNCT
dti-1305	726	1	in	in	ADP
dti-1305	726	2	vivo	vivo	ADJ
dti-1305	726	3	inhibition	inhibition	NOUN
dti-1305	726	4	of	of	ADP
dti-1305	726	5	trypanosome	trypanosome	NUM
dti-1305	726	6	mitochondrial	mitochondrial	ADJ
dti-1305	726	7	topoisomerase	topoisomerase	ADJ
dti-1305	726	8	ii	ii	PROPN
dti-1305	726	9	:	:	PUNCT
dti-1305	726	10	effects	effect	NOUN
dti-1305	726	11	on	on	ADP
dti-1305	726	12	kinetoplast	kinetoplast	ADJ
dti-1305	726	13	dna	dna	PROPN
dti-1305	726	14	maxicircles	maxicircle	NOUN
dti-1305	726	15	.	.	PUNCT
dti-1305	727	1	mol	mol	PROPN
dti-1305	727	2	.	.	PROPN
dti-1305	727	3	cell	cell	NOUN
dti-1305	727	4	.	.	PUNCT
dti-1305	728	1	biol	biol	PROPN
dti-1305	728	2	.	.	PUNCT
dti-1305	728	3	,	,	PUNCT
dti-1305	728	4	14:5891–7	14:5891–7	X
dti-1305	728	5	.	.	PUNCT
dti-1305	728	6	tekwani	tekwani	PROPN
dti-1305	728	7	,	,	PUNCT
dti-1305	728	8	b.l	b.l	PROPN
dti-1305	728	9	.	.	PROPN
dti-1305	728	10	,	,	PUNCT
dti-1305	728	11	bacchi	bacchi	PROPN
dti-1305	728	12	,	,	PUNCT
dti-1305	728	13	c.j	c.j	PROPN
dti-1305	728	14	.	.	PROPN
dti-1305	728	15	,	,	PUNCT
dti-1305	728	16	pegg	pegg	PROPN
dti-1305	728	17	,	,	PUNCT
dti-1305	728	18	a.e	a.e	PROPN
dti-1305	728	19	.	.	PROPN
dti-1305	728	20	1992	1992	NUM
dti-1305	728	21	.	.	PUNCT
dti-1305	729	1	putrescine	putrescine	NOUN
dti-1305	729	2	activated	activate	VERB
dti-1305	729	3	s	s	NOUN
dti-1305	729	4	-	-	PUNCT
dti-1305	729	5	adenosylmethionine	adenosylmethionine	NOUN
dti-1305	729	6	decarboxylase	decarboxylase	NOUN
dti-1305	729	7	from	from	ADP
dti-1305	729	8	trypanosoma	trypanosoma	PROPN
dti-1305	729	9	brucei	brucei	PROPN
dti-1305	729	10	brucei	brucei	PROPN
dti-1305	729	11	.	.	PUNCT
dti-1305	730	1	mol	mol	PROPN
dti-1305	730	2	.	.	PROPN
dti-1305	730	3	cell	cell	NOUN
dti-1305	730	4	.	.	PUNCT
dti-1305	731	1	biochem	biochem	PROPN
dti-1305	731	2	.	.	PUNCT
dti-1305	731	3	,	,	PUNCT
dti-1305	731	4	117:53–61	117:53–61	X
dti-1305	731	5	.	.	X
dti-1305	731	6	tovar	tovar	PROPN
dti-1305	731	7	,	,	PUNCT
dti-1305	731	8	j.	j.	PROPN
dti-1305	731	9	and	and	CCONJ
dti-1305	731	10	fairlamb	fairlamb	PROPN
dti-1305	731	11	,	,	PUNCT
dti-1305	731	12	a.h	a.h	PROPN
dti-1305	731	13	.	.	PROPN
dti-1305	731	14	1996	1996	NUM
dti-1305	731	15	.	.	PUNCT
dti-1305	732	1	extrachromosomal	extrachromosomal	ADJ
dti-1305	732	2	homologous	homologous	ADJ
dti-1305	732	3	expression	expression	NOUN
dti-1305	732	4	of	of	ADP
dti-1305	732	5	trypanothione	trypanothione	NOUN
dti-1305	732	6	reductase	reductase	NOUN
dti-1305	732	7	and	and	CCONJ
dti-1305	732	8	its	its	PRON
dti-1305	732	9	complementary	complementary	ADJ
dti-1305	732	10	mrna	mrna	NOUN
dti-1305	732	11	in	in	ADP
dti-1305	732	12	trypanosoma	trypanosoma	PROPN
dti-1305	733	1	cruzi	cruzi	PROPN
dti-1305	733	2	.	.	PUNCT
dti-1305	734	1	nucl	nucl	PROPN
dti-1305	734	2	.	.	PUNCT
dti-1305	735	1	acids	acid	NOUN
dti-1305	735	2	.	.	PUNCT
dti-1305	736	1	res	re	NOUN
dti-1305	736	2	.	.	PROPN
dti-1305	736	3	,	,	PUNCT
dti-1305	736	4	24:2942–9	24:2942–9	NUM
dti-1305	736	5	.	.	X
dti-1305	737	1	tovar	tovar	PROPN
dti-1305	737	2	,	,	PUNCT
dti-1305	737	3	j.	j.	PROPN
dti-1305	737	4	,	,	PUNCT
dti-1305	737	5	cunningham	cunningham	PROPN
dti-1305	737	6	,	,	PUNCT
dti-1305	737	7	m.l	m.l	PROPN
dti-1305	737	8	.	.	PROPN
dti-1305	737	9	,	,	PUNCT
dti-1305	737	10	smith	smith	PROPN
dti-1305	737	11	,	,	PUNCT
dti-1305	737	12	a.c	a.c	PROPN
dti-1305	737	13	.	.	PROPN
dti-1305	737	14	et	et	PROPN
dti-1305	737	15	al	al	PROPN
dti-1305	737	16	.	.	PROPN
dti-1305	737	17	1998a	1998a	NUM
dti-1305	737	18	.	.	PUNCT
dti-1305	738	1	down	down	ADP
dti-1305	738	2	-	-	PUNCT
dti-1305	738	3	regulation	regulation	NOUN
dti-1305	738	4	of	of	ADP
dti-1305	738	5	leishmania	leishmania	NOUN
dti-1305	738	6	donovani	donovani	ADJ
dti-1305	738	7	trypanothione	trypanothione	PROPN
dti-1305	738	8	reductase	reductase	NOUN
dti-1305	738	9	by	by	ADP
dti-1305	738	10	heterologous	heterologous	ADJ
dti-1305	738	11	expression	expression	NOUN
dti-1305	738	12	of	of	ADP
dti-1305	738	13	a	a	DET
dti-1305	738	14	trans	trans	ADJ
dti-1305	738	15	-	-	ADJ
dti-1305	738	16	dominant	dominant	ADJ
dti-1305	738	17	mutant	mutant	ADJ
dti-1305	738	18	homolog	homolog	NOUN
dti-1305	738	19	:	:	PUNCT
dti-1305	738	20	effect	effect	NOUN
dti-1305	738	21	on	on	ADP
dti-1305	738	22	parasite	parasite	ADJ
dti-1305	738	23	intracellular	intracellular	ADJ
dti-1305	738	24	survival	survival	NOUN
dti-1305	738	25	.	.	PUNCT
dti-1305	739	1	proc	proc	PROPN
dti-1305	739	2	.	.	PUNCT
dti-1305	740	1	natl	natl	PROPN
dti-1305	740	2	.	.	PUNCT
dti-1305	741	1	acad	acad	PROPN
dti-1305	741	2	.	.	PUNCT
dti-1305	742	1	sci	sci	PROPN
dti-1305	742	2	.	.	PUNCT
dti-1305	742	3	u.s.a	u.s.a	PROPN
dti-1305	742	4	.	.	PROPN
dti-1305	742	5	,	,	PUNCT
dti-1305	742	6	95:5311–5316	95:5311–5316	NUM
dti-1305	742	7	.	.	PUNCT
dti-1305	743	1	tovar	tovar	PROPN
dti-1305	743	2	,	,	PUNCT
dti-1305	743	3	j.	j.	PROPN
dti-1305	743	4	,	,	PUNCT
dti-1305	743	5	wilkinson	wilkinson	PROPN
dti-1305	743	6	,	,	PUNCT
dti-1305	743	7	s.	s.	PROPN
dti-1305	743	8	,	,	PUNCT
dti-1305	743	9	mottram	mottram	PROPN
dti-1305	743	10	,	,	PUNCT
dti-1305	743	11	j.c	j.c	PROPN
dti-1305	743	12	.	.	PROPN
dti-1305	743	13	et	et	PROPN
dti-1305	743	14	al	al	PROPN
dti-1305	743	15	.	.	PROPN
dti-1305	743	16	1998b	1998b	PROPN
dti-1305	743	17	.	.	PUNCT
dti-1305	744	1	evidence	evidence	NOUN
dti-1305	744	2	that	that	SCONJ
dti-1305	744	3	trypanothione	trypanothione	NOUN
dti-1305	744	4	reductase	reductase	NOUN
dti-1305	744	5	is	be	AUX
dti-1305	744	6	an	an	DET
dti-1305	744	7	essential	essential	ADJ
dti-1305	744	8	enzyme	enzyme	NOUN
dti-1305	744	9	in	in	ADP
dti-1305	744	10	leishmania	leishmania	NOUN
dti-1305	744	11	by	by	ADP
dti-1305	744	12	targeted	target	VERB
dti-1305	744	13	replacement	replacement	NOUN
dti-1305	744	14	of	of	ADP
dti-1305	744	15	the	the	DET
dti-1305	744	16	trya	trya	ADJ
dti-1305	744	17	gene	gene	NOUN
dti-1305	744	18	locus	locus	NOUN
dti-1305	744	19	.	.	PUNCT
dti-1305	745	1	mol	mol	PROPN
dti-1305	745	2	.	.	PROPN
dti-1305	745	3	microbiol	microbiol	PROPN
dti-1305	745	4	.	.	PUNCT
dti-1305	746	1	,	,	PUNCT
dti-1305	746	2	29:653–60	29:653–60	PROPN
dti-1305	746	3	.	.	PUNCT
dti-1305	747	1	urbina	urbina	PROPN
dti-1305	747	2	,	,	PUNCT
dti-1305	747	3	j.a	j.a	PROPN
dti-1305	747	4	.	.	PROPN
dti-1305	747	5	,	,	PUNCT
dti-1305	747	6	2003	2003	NUM
dti-1305	747	7	.	.	PUNCT
dti-1305	748	1	rational	rational	ADJ
dti-1305	748	2	approach	approach	NOUN
dti-1305	748	3	to	to	ADP
dti-1305	748	4	specifi	specifi	PROPN
dti-1305	748	5	c	c	PROPN
dti-1305	748	6	chemotherapy	chemotherapy	NOUN
dti-1305	748	7	of	of	ADP
dti-1305	748	8	chagas	chagas	PROPN
dti-1305	748	9	disease	disease	NOUN
dti-1305	748	10	.	.	PUNCT
dti-1305	749	1	world	world	NOUN
dti-1305	749	2	class	class	NOUN
dti-1305	749	3	parasites	parasite	NOUN
dti-1305	749	4	,	,	PUNCT
dti-1305	749	5	7:127–35	7:127–35	PROPN
dti-1305	749	6	.	.	PUNCT
dti-1305	750	1	vega	vega	PROPN
dti-1305	750	2	-	-	PUNCT
dti-1305	750	3	teijido	teijido	PROPN
dti-1305	750	4	,	,	PUNCT
dti-1305	750	5	m.	m.	NOUN
dti-1305	750	6	,	,	PUNCT
dti-1305	750	7	caracelli	caracelli	PROPN
dti-1305	750	8	,	,	PUNCT
dti-1305	750	9	i.	i.	PROPN
dti-1305	750	10	,	,	PUNCT
dti-1305	750	11	zuckerman	zuckerman	NOUN
dti-1305	750	12	-	-	PUNCT
dti-1305	750	13	schpector	schpector	NOUN
dti-1305	750	14	,	,	PUNCT
dti-1305	750	15	j.	j.	PROPN
dti-1305	750	16	et	et	PROPN
dti-1305	750	17	al	al	PROPN
dti-1305	750	18	.	.	PROPN
dti-1305	750	19	2006	2006	NUM
dti-1305	750	20	.	.	PUNCT
dti-1305	751	1	conformational	conformational	ADJ
dti-1305	751	2	analyses	analysis	NOUN
dti-1305	751	3	and	and	CCONJ
dti-1305	751	4	docking	dock	VERB
dti-1305	751	5	studies	study	NOUN
dti-1305	751	6	of	of	ADP
dti-1305	751	7	a	a	DET
dti-1305	751	8	series	series	NOUN
dti-1305	751	9	of	of	ADP
dti-1305	751	10	5	5	NUM
dti-1305	751	11	-	-	PUNCT
dti-1305	751	12	nitrofuran	nitrofuran	NOUN
dti-1305	751	13	and	and	CCONJ
dti-1305	751	14	5	5	NUM
dti-1305	751	15	-	-	PUNCT
dti-1305	751	16	nitrothiophenesemicarbazone	nitrothiophenesemicarbazone	ADJ
dti-1305	751	17	derivatives	derivative	NOUN
dti-1305	751	18	in	in	ADP
dti-1305	751	19	three	three	NUM
dti-1305	751	20	possible	possible	ADJ
dti-1305	751	21	binding	bind	VERB
dti-1305	751	22	sites	site	NOUN
dti-1305	751	23	of	of	ADP
dti-1305	751	24	trypanothione	trypanothione	NOUN
dti-1305	751	25	and	and	CCONJ
dti-1305	751	26	glutathione	glutathione	NOUN
dti-1305	751	27	reductases	reductase	NOUN
dti-1305	751	28	.	.	PUNCT
dti-1305	752	1	j.	j.	PROPN
dti-1305	752	2	mol	mol	PROPN
dti-1305	752	3	.	.	PROPN
dti-1305	752	4	graph	graph	PROPN
dti-1305	752	5	.	.	PUNCT
dti-1305	752	6	model	model	PROPN
dti-1305	752	7	.	.	PUNCT
dti-1305	752	8	,	,	PUNCT
dti-1305	752	9	24:349–55	24:349–55	NUM
dti-1305	752	10	.	.	PUNCT
dti-1305	753	1	vellieux	vellieux	PROPN
dti-1305	753	2	,	,	PUNCT
dti-1305	753	3	f.m.d	f.m.d	PROPN
dti-1305	753	4	.	.	PROPN
dti-1305	753	5	,	,	PUNCT
dti-1305	753	6	hajdu	hajdu	PROPN
dti-1305	753	7	,	,	PUNCT
dti-1305	753	8	j.	j.	PROPN
dti-1305	753	9	,	,	PUNCT
dti-1305	753	10	verlinde	verlinde	PROPN
dti-1305	753	11	,	,	PUNCT
dti-1305	753	12	c.l.m.j	c.l.m.j	PROPN
dti-1305	753	13	.	.	PROPN
dti-1305	753	14	et	et	PROPN
dti-1305	753	15	al	al	PROPN
dti-1305	753	16	.	.	PROPN
dti-1305	753	17	1993	1993	NUM
dti-1305	753	18	.	.	PUNCT
dti-1305	754	1	structure	structure	NOUN
dti-1305	754	2	of	of	ADP
dti-1305	754	3	glycosomal	glycosomal	ADJ
dti-1305	754	4	glyceraldehyde-3	glyceraldehyde-3	VERB
dti-1305	754	5	-	-	ADJ
dti-1305	754	6	phosphate	phosphate	ADJ
dti-1305	754	7	dehydrogenase	dehydrogenase	NOUN
dti-1305	754	8	from	from	ADP
dti-1305	754	9	trypanosoma	trypanosoma	PROPN
dti-1305	754	10	brucei	brucei	PROPN
dti-1305	754	11	determined	determine	VERB
dti-1305	754	12	from	from	ADP
dti-1305	754	13	laue	laue	PROPN
dti-1305	754	14	data	data	PROPN
dti-1305	754	15	.	.	PUNCT
dti-1305	755	1	proc	proc	PROPN
dti-1305	755	2	.	.	PUNCT
dti-1305	756	1	natl	natl	PROPN
dti-1305	756	2	.	.	PUNCT
dti-1305	757	1	acad	acad	PROPN
dti-1305	757	2	.	.	PUNCT
dti-1305	758	1	sci	sci	PROPN
dti-1305	758	2	.	.	PUNCT
dti-1305	758	3	u.s.a	u.s.a	PROPN
dti-1305	758	4	.	.	PROPN
dti-1305	758	5	,	,	PUNCT
dti-1305	758	6	90:2355–9	90:2355–9	PROPN
dti-1305	758	7	.	.	PUNCT
dti-1305	759	1	verlinde	verlinde	PROPN
dti-1305	759	2	,	,	PUNCT
dti-1305	759	3	c.l.m.j	c.l.m.j	PROPN
dti-1305	759	4	.	.	PROPN
dti-1305	759	5	,	,	PUNCT
dti-1305	759	6	callens	callen	NOUN
dti-1305	759	7	,	,	PUNCT
dti-1305	759	8	m.	m.	NOUN
dti-1305	759	9	,	,	PUNCT
dti-1305	759	10	van	van	PROPN
dti-1305	759	11	calenbergh	calenbergh	PROPN
dti-1305	759	12	,	,	PUNCT
dti-1305	759	13	s.	s.	PROPN
dti-1305	759	14	et	et	PROPN
dti-1305	759	15	al	al	PROPN
dti-1305	759	16	.	.	PROPN
dti-1305	759	17	1994	1994	NUM
dti-1305	759	18	.	.	PUNCT
dti-1305	760	1	selective	selective	ADJ
dti-1305	760	2	inhibition	inhibition	NOUN
dti-1305	760	3	of	of	ADP
dti-1305	760	4	trypanosomal	trypanosomal	ADJ
dti-1305	760	5	glyceraldehyde-3	glyceraldehyde-3	VERB
dti-1305	760	6	-	-	ADJ
dti-1305	760	7	phosphate	phosphate	ADJ
dti-1305	760	8	dehydrogenase	dehydrogenase	NOUN
dti-1305	760	9	by	by	ADP
dti-1305	760	10	protein	protein	NOUN
dti-1305	760	11	structure	structure	NOUN
dti-1305	760	12	-	-	PUNCT
dti-1305	760	13	based	base	VERB
dti-1305	760	14	design	design	NOUN
dti-1305	760	15	:	:	PUNCT
dti-1305	760	16	toward	toward	ADP
dti-1305	760	17	new	new	ADJ
dti-1305	760	18	drugs	drug	NOUN
dti-1305	760	19	for	for	ADP
dti-1305	760	20	the	the	DET
dti-1305	760	21	treatment	treatment	NOUN
dti-1305	760	22	of	of	ADP
dti-1305	760	23	sleeping	sleep	VERB
dti-1305	760	24	sickness	sickness	NOUN
dti-1305	760	25	.	.	PUNCT
dti-1305	761	1	j.	j.	PROPN
dti-1305	761	2	med	med	PROPN
dti-1305	761	3	.	.	PROPN
dti-1305	761	4	chem	chem	PROPN
dti-1305	761	5	.	.	PUNCT
dti-1305	761	6	,	,	PUNCT
dti-1305	761	7	37:3605–13	37:3605–13	NUM
dti-1305	761	8	.	.	PUNCT
dti-1305	762	1	wang	wang	PROPN
dti-1305	762	2	,	,	PUNCT
dti-1305	762	3	c.c	c.c	PROPN
dti-1305	762	4	.	.	PROPN
dti-1305	762	5	1995	1995	NUM
dti-1305	762	6	.	.	PUNCT
dti-1305	763	1	molecular	molecular	ADJ
dti-1305	763	2	mechanisms	mechanism	NOUN
dti-1305	763	3	and	and	CCONJ
dti-1305	763	4	therapeutic	therapeutic	ADJ
dti-1305	763	5	approaches	approach	NOUN
dti-1305	763	6	to	to	ADP
dti-1305	763	7	the	the	DET
dti-1305	763	8	treatment	treatment	NOUN
dti-1305	763	9	of	of	ADP
dti-1305	763	10	african	african	ADJ
dti-1305	763	11	trypanosomiasis	trypanosomiasis	NOUN
dti-1305	763	12	.	.	PUNCT
dti-1305	764	1	annu	annu	NOUN
dti-1305	764	2	.	.	PUNCT
dti-1305	765	1	rev	rev	PROPN
dti-1305	765	2	.	.	PROPN
dti-1305	765	3	pharmacol	pharmacol	PROPN
dti-1305	765	4	.	.	PUNCT
dti-1305	766	1	toxicol	toxicol	PROPN
dti-1305	766	2	.	.	PUNCT
dti-1305	766	3	,	,	PUNCT
dti-1305	766	4	35:93–127	35:93–127	NUM
dti-1305	766	5	.	.	PUNCT
dti-1305	767	1	wierenga	wierenga	PROPN
dti-1305	767	2	,	,	PUNCT
dti-1305	767	3	r.k	r.k	PROPN
dti-1305	767	4	.	.	PROPN
dti-1305	767	5	,	,	PUNCT
dti-1305	767	6	kalk	kalk	PROPN
dti-1305	767	7	,	,	PUNCT
dti-1305	767	8	k.h	k.h	PROPN
dti-1305	767	9	.	.	PROPN
dti-1305	767	10	and	and	CCONJ
dti-1305	767	11	hol	hol	NOUN
dti-1305	767	12	,	,	PUNCT
dti-1305	767	13	w.g.j	w.g.j	NOUN
dti-1305	767	14	.	.	PUNCT
dti-1305	767	15	1987	1987	NUM
dti-1305	767	16	.	.	PUNCT
dti-1305	768	1	structure	structure	NOUN
dti-1305	768	2	determination	determination	NOUN
dti-1305	768	3	of	of	ADP
dti-1305	768	4	the	the	DET
dti-1305	768	5	glycosomal	glycosomal	ADJ
dti-1305	768	6	triosephosphate	triosephosphate	ADJ
dti-1305	768	7	isomerase	isomerase	NOUN
dti-1305	768	8	from	from	ADP
dti-1305	768	9	trypanosoma	trypanosoma	PROPN
dti-1305	768	10	brucei	brucei	PROPN
dti-1305	768	11	brucei	brucei	PROPN
dti-1305	768	12	at	at	ADP
dti-1305	768	13	2.4	2.4	NUM
dti-1305	768	14	å	å	PROPN
dti-1305	768	15	resolution	resolution	NOUN
dti-1305	768	16	.	.	PUNCT
dti-1305	769	1	j.	j.	PROPN
dti-1305	769	2	mol	mol	PROPN
dti-1305	769	3	.	.	PUNCT
dti-1305	770	1	biol	biol	PROPN
dti-1305	770	2	.	.	PUNCT
dti-1305	770	3	,	,	PUNCT
dti-1305	771	1	198:109–21	198:109–21	NUM
dti-1305	771	2	.	.	PUNCT
dti-1305	772	1	williams	williams	PROPN
dti-1305	772	2	,	,	PUNCT
dti-1305	772	3	c.h.jr	c.h.jr	PROPN
dti-1305	772	4	,	,	PUNCT
dti-1305	772	5	1992	1992	NUM
dti-1305	772	6	.	.	PUNCT
dti-1305	773	1	lipoamide	lipoamide	ADJ
dti-1305	773	2	dehydrogenase	dehydrogenase	NOUN
dti-1305	773	3	,	,	PUNCT
dti-1305	773	4	glutathione	glutathione	NOUN
dti-1305	773	5	reductase	reductase	NOUN
dti-1305	773	6	,	,	PUNCT
dti-1305	773	7	thioredoxin	thioredoxin	PROPN
dti-1305	773	8	reductase	reductase	NOUN
dti-1305	773	9	,	,	PUNCT
dti-1305	773	10	and	and	CCONJ
dti-1305	773	11	mercuric	mercuric	ADJ
dti-1305	773	12	ion	ion	NOUN
dti-1305	773	13	reductase	reductase	NOUN
dti-1305	773	14	.	.	PUNCT
dti-1305	774	1	a	a	DET
dti-1305	774	2	family	family	NOUN
dti-1305	774	3	of	of	ADP
dti-1305	774	4	fl	fl	PROPN
dti-1305	774	5	avoenzyme	avoenzyme	NOUN
dti-1305	774	6	transhydrogenases	transhydrogenase	NOUN
dti-1305	774	7	.	.	PUNCT
dti-1305	775	1	chem	chem	NOUN
dti-1305	775	2	.	.	PUNCT
dti-1305	776	1	biochem	biochem	PROPN
dti-1305	776	2	.	.	PUNCT
dti-1305	777	1	flavoenzymes	flavoenzyme	NOUN
dti-1305	777	2	.	.	PUNCT
dti-1305	777	3	,	,	PUNCT
dti-1305	777	4	3:121–211	3:121–211	NUM
dti-1305	777	5	.	.	PUNCT
dti-1305	778	1	zhang	zhang	PROPN
dti-1305	778	2	,	,	PUNCT
dti-1305	778	3	y.	y.	PROPN
dti-1305	778	4	,	,	PUNCT
dti-1305	778	5	bond	bond	PROPN
dti-1305	778	6	,	,	PUNCT
dti-1305	778	7	c.s	c.s	PROPN
dti-1305	778	8	.	.	PROPN
dti-1305	778	9	,	,	PUNCT
dti-1305	778	10	bailey	bailey	PROPN
dti-1305	778	11	,	,	PUNCT
dti-1305	778	12	s.	s.	PROPN
dti-1305	778	13	et	et	PROPN
dti-1305	778	14	al	al	PROPN
dti-1305	778	15	.	.	PROPN
dti-1305	778	16	1996	1996	NUM
dti-1305	778	17	.	.	PUNCT
dti-1305	779	1	the	the	DET
dti-1305	779	2	crystal	crystal	NOUN
dti-1305	779	3	structure	structure	NOUN
dti-1305	779	4	of	of	ADP
dti-1305	779	5	trypanothione	trypanothione	NOUN
dti-1305	779	6	reductase	reductase	NOUN
dti-1305	779	7	from	from	ADP
dti-1305	779	8	the	the	DET
dti-1305	779	9	human	human	ADJ
dti-1305	779	10	pathogen	pathogen	NOUN
dti-1305	779	11	trypanosoma	trypanosoma	PROPN
dti-1305	779	12	cruzi	cruzi	PROPN
dti-1305	779	13	at	at	ADP
dti-1305	779	14	2.3	2.3	NUM
dti-1305	779	15	å	å	NOUN
dti-1305	779	16	resolution	resolution	NOUN
dti-1305	779	17	.	.	PUNCT
dti-1305	780	1	protein	protein	NOUN
dti-1305	780	2	science	science	NOUN
dti-1305	780	3	,	,	PUNCT
dti-1305	780	4	5:52–61	5:52–61	NUM
dti-1305	780	5	.	.	PUNCT
dti-1305	780	6	drug	drug	NOUN
dti-1305	780	7	target	target	NOUN
dti-1305	780	8	insights	insight	NOUN
dti-1305	780	9	2007	2007	NUM
dti-1305	780	10	:	:	PUNCT
dti-1305	780	11	2	2	NUM
dti-1305	780	12	<	<	X
dti-1305	780	13	<	<	X
dti-1305	780	14	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1305	780	15	false	false	ADJ
dti-1305	780	16	/allowtransparency	/allowtransparency	NOUN
dti-1305	780	17	false	false	ADJ
dti-1305	780	18	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1305	780	19	true	true	ADJ
dti-1305	780	20	/autorotatepages	/autorotatepage	NOUN
dti-1305	780	21	/none	/none	PUNCT
dti-1305	780	22	/binding	/binding	PUNCT
dti-1305	780	23	/left	/left	ADJ
dti-1305	781	1	/calgrayprofile	/calgrayprofile	VERB
dti-1305	781	2	(	(	PUNCT
dti-1305	781	3	dot	dot	NOUN
dti-1305	781	4	gain	gain	NOUN
dti-1305	781	5	20	20	NUM
dti-1305	781	6	%	%	NOUN
dti-1305	781	7	)	)	PUNCT
dti-1305	781	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1305	782	1	(	(	PUNCT
dti-1305	782	2	srgb	srgb	PROPN
dti-1305	782	3	iec61966	iec61966	NOUN
dti-1305	782	4	-	-	PUNCT
dti-1305	782	5	2.1	2.1	NUM
dti-1305	782	6	)	)	PUNCT
dti-1305	782	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1305	783	1	(	(	PUNCT
dti-1305	783	2	u.s	u.s	PROPN
dti-1305	783	3	.	.	PROPN
dti-1305	783	4	web	web	NOUN
dti-1305	783	5	coated	coat	VERB
dti-1305	783	6	\050swop\051	\050swop\051	ADJ
dti-1305	783	7	v2	v2	NOUN
dti-1305	783	8	)	)	PUNCT
dti-1305	783	9	/srgbprofile	/srgbprofile	PUNCT
dti-1305	783	10	(	(	PUNCT
dti-1305	783	11	srgb	srgb	PROPN
dti-1305	783	12	iec61966	iec61966	NOUN
dti-1305	783	13	-	-	PUNCT
dti-1305	783	14	2.1	2.1	NUM
dti-1305	783	15	)	)	PUNCT
dti-1305	783	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1305	784	1	/error	/error	INTJ
dti-1305	784	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1305	785	1	1.4	1.4	NUM
dti-1305	785	2	/compressobjects	/compressobject	NOUN
dti-1305	785	3	/tags	/tag	VERB
dti-1305	785	4	/compresspages	/compresspage	NOUN
dti-1305	785	5	true	true	ADJ
dti-1305	785	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1305	785	7	true	true	ADJ
dti-1305	785	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1305	785	9	true	true	ADJ
dti-1305	785	10	/createjdffile	/createjdffile	ADJ
dti-1305	785	11	false	false	ADJ
dti-1305	785	12	/createjobticket	/createjobticket	NOUN
dti-1305	785	13	false	false	ADJ
dti-1305	785	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1305	785	15	/default	/default	PUNCT
dti-1305	785	16	/detectblends	/detectblend	NOUN
dti-1305	785	17	true	true	ADJ
dti-1305	785	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1305	785	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1305	785	20	/dothumbnails	/dothumbnail	VERB
dti-1305	785	21	false	false	ADJ
dti-1305	785	22	/embedallfonts	/embedallfont	NOUN
dti-1305	785	23	true	true	ADJ
dti-1305	785	24	/embedjoboptions	/embedjoboption	NOUN
dti-1305	785	25	true	true	ADJ
dti-1305	785	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1305	785	27	0	0	NUM
dti-1305	785	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1305	785	29	false	false	ADJ
dti-1305	785	30	/endpage	/endpage	NOUN
dti-1305	785	31	-1	-1	NOUN
dti-1305	785	32	/imagememory	/imagememory	NUM
dti-1305	786	1	1048576	1048576	NUM
dti-1305	786	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1305	786	3	false	false	ADJ
dti-1305	786	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1305	786	5	100	100	NUM
dti-1305	786	6	/optimize	/optimize	NOUN
dti-1305	786	7	true	true	ADJ
dti-1305	786	8	/opm	/opm	NOUN
dti-1305	786	9	1	1	NUM
dti-1305	786	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1305	786	11	true	true	ADJ
dti-1305	786	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1305	786	13	true	true	ADJ
dti-1305	786	14	/preservecopypage	/preservecopypage	NOUN
dti-1305	786	15	true	true	ADJ
dti-1305	786	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1305	786	17	true	true	ADJ
dti-1305	786	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1305	786	19	false	false	ADJ
dti-1305	786	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1305	786	21	false	false	ADJ
dti-1305	786	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1305	786	23	true	true	ADJ
dti-1305	786	24	/startpage	/startpage	NOUN
dti-1305	786	25	1	1	NUM
dti-1305	786	26	/subsetfonts	/subsetfont	NOUN
dti-1305	786	27	true	true	ADJ
dti-1305	786	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1305	786	29	/apply	/apply	PUNCT
dti-1305	786	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1305	787	1	/preserve	/preserve	NOUN
dti-1305	787	2	/useprologue	/useprologue	NOUN
dti-1305	787	3	false	false	ADJ
dti-1305	787	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1305	787	5	(	(	PUNCT
dti-1305	787	6	)	)	PUNCT
dti-1305	787	7	/alwaysembed	/alwaysembe	VERB
dti-1305	787	8	[	[	PUNCT
dti-1305	787	9	true	true	ADJ
dti-1305	787	10	]	]	PUNCT
dti-1305	787	11	/neverembed	/neverembed	PUNCT
dti-1305	788	1	[	[	PUNCT
dti-1305	788	2	true	true	ADJ
dti-1305	788	3	]	]	PUNCT
dti-1305	788	4	/antialiascolorimages	/antialiascolorimages	X
dti-1305	788	5	false	false	ADJ
dti-1305	788	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1305	788	7	true	true	ADJ
dti-1305	788	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1305	788	9	/bicubic	/bicubic	NOUN
dti-1305	788	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1305	788	11	300	300	NUM
dti-1305	788	12	/colorimagedepth	/colorimagedepth	PRON
dti-1305	789	1	-1	-1	INTJ
dti-1305	789	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1305	789	3	1.50000	1.50000	NUM
dti-1305	789	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1305	789	5	true	true	ADJ
dti-1305	789	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1305	789	7	/dctencode	/dctencode	PUNCT
dti-1305	789	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1305	789	9	true	true	ADJ
dti-1305	789	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1305	789	11	/jpeg	/jpeg	PUNCT
dti-1305	789	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1305	790	1	<	<	X
dti-1305	790	2	<	<	X
dti-1305	790	3	/qfactor	/qfactor	NOUN
dti-1305	790	4	0.15	0.15	NUM
dti-1305	790	5	/hsamples	/hsample	NOUN
dti-1305	791	1	[	[	X
dti-1305	791	2	1	1	NUM
dti-1305	791	3	1	1	NUM
dti-1305	791	4	1	1	NUM
dti-1305	791	5	1	1	NUM
dti-1305	791	6	]	]	PUNCT
dti-1305	791	7	/vsamples	/vsample	NOUN
dti-1305	792	1	[	[	X
dti-1305	792	2	1	1	NUM
dti-1305	792	3	1	1	NUM
dti-1305	792	4	1	1	NUM
dti-1305	792	5	1	1	NUM
dti-1305	792	6	]	]	PUNCT
dti-1305	792	7	>	>	PUNCT
dti-1305	792	8	>	>	X
dti-1305	792	9	/colorimagedict	/colorimagedict	PUNCT
dti-1305	793	1	<	<	X
dti-1305	793	2	<	<	X
dti-1305	793	3	/qfactor	/qfactor	NOUN
dti-1305	793	4	0.15	0.15	NUM
dti-1305	793	5	/hsamples	/hsample	NOUN
dti-1305	794	1	[	[	X
dti-1305	794	2	1	1	NUM
dti-1305	794	3	1	1	NUM
dti-1305	794	4	1	1	NUM
dti-1305	794	5	1	1	NUM
dti-1305	794	6	]	]	PUNCT
dti-1305	794	7	/vsamples	/vsample	NOUN
dti-1305	795	1	[	[	X
dti-1305	795	2	1	1	NUM
dti-1305	795	3	1	1	NUM
dti-1305	795	4	1	1	NUM
dti-1305	795	5	1	1	NUM
dti-1305	795	6	]	]	PUNCT
dti-1305	795	7	>	>	PUNCT
dti-1305	795	8	>	>	X
dti-1305	795	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1305	796	1	<	<	X
dti-1305	796	2	<	<	X
dti-1305	796	3	/tilewidth	/tilewidth	PUNCT
dti-1305	796	4	256	256	NUM
dti-1305	796	5	/tileheight	/tileheight	NUM
dti-1305	796	6	256	256	NUM
dti-1305	796	7	/quality	/quality	NOUN
dti-1305	796	8	30	30	NUM
dti-1305	796	9	>	>	PUNCT
dti-1305	796	10	>	>	X
dti-1305	796	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1305	796	12	<	<	X
dti-1305	796	13	<	<	X
dti-1305	796	14	/tilewidth	/tilewidth	PUNCT
dti-1305	796	15	256	256	NUM
dti-1305	796	16	/tileheight	/tileheight	NUM
dti-1305	796	17	256	256	NUM
dti-1305	796	18	/quality	/quality	NOUN
dti-1305	796	19	30	30	NUM
dti-1305	796	20	>	>	PUNCT
dti-1305	796	21	>	>	X
dti-1305	796	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1305	796	23	false	false	ADJ
dti-1305	796	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1305	797	1	true	true	ADJ
dti-1305	797	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1305	797	3	/bicubic	/bicubic	NOUN
dti-1305	797	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1305	797	5	300	300	NUM
dti-1305	797	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1305	797	7	-1	-1	PUNCT
dti-1305	797	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1305	798	1	1.50000	1.50000	NUM
dti-1305	798	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1305	798	3	true	true	ADJ
dti-1305	798	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1305	798	5	/dctencode	/dctencode	PUNCT
dti-1305	799	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1305	799	2	true	true	ADJ
dti-1305	799	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1305	799	4	/jpeg	/jpeg	PUNCT
dti-1305	799	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1305	800	1	<	<	X
dti-1305	800	2	<	<	X
dti-1305	800	3	/qfactor	/qfactor	NOUN
dti-1305	800	4	0.15	0.15	NUM
dti-1305	800	5	/hsamples	/hsample	NOUN
dti-1305	801	1	[	[	X
dti-1305	801	2	1	1	NUM
dti-1305	801	3	1	1	NUM
dti-1305	801	4	1	1	NUM
dti-1305	801	5	1	1	NUM
dti-1305	801	6	]	]	PUNCT
dti-1305	801	7	/vsamples	/vsample	NOUN
dti-1305	802	1	[	[	X
dti-1305	802	2	1	1	NUM
dti-1305	802	3	1	1	NUM
dti-1305	802	4	1	1	NUM
dti-1305	802	5	1	1	NUM
dti-1305	802	6	]	]	PUNCT
dti-1305	802	7	>	>	PUNCT
dti-1305	802	8	>	>	X
dti-1305	802	9	/grayimagedict	/grayimagedict	PUNCT
dti-1305	803	1	<	<	X
dti-1305	803	2	<	<	X
dti-1305	803	3	/qfactor	/qfactor	NOUN
dti-1305	803	4	0.15	0.15	NUM
dti-1305	803	5	/hsamples	/hsample	NOUN
dti-1305	804	1	[	[	X
dti-1305	804	2	1	1	NUM
dti-1305	804	3	1	1	NUM
dti-1305	804	4	1	1	NUM
dti-1305	804	5	1	1	NUM
dti-1305	804	6	]	]	PUNCT
dti-1305	804	7	/vsamples	/vsample	NOUN
dti-1305	805	1	[	[	X
dti-1305	805	2	1	1	NUM
dti-1305	805	3	1	1	NUM
dti-1305	805	4	1	1	NUM
dti-1305	805	5	1	1	NUM
dti-1305	805	6	]	]	PUNCT
dti-1305	805	7	>	>	X
dti-1305	805	8	>	>	X
dti-1305	805	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1305	806	1	<	<	X
dti-1305	806	2	<	<	X
dti-1305	806	3	/tilewidth	/tilewidth	PUNCT
dti-1305	806	4	256	256	NUM
dti-1305	806	5	/tileheight	/tileheight	NUM
dti-1305	806	6	256	256	NUM
dti-1305	806	7	/quality	/quality	NOUN
dti-1305	806	8	30	30	NUM
dti-1305	806	9	>	>	PUNCT
dti-1305	806	10	>	>	X
dti-1305	806	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1305	806	12	<	<	X
dti-1305	806	13	<	<	X
dti-1305	806	14	/tilewidth	/tilewidth	PUNCT
dti-1305	806	15	256	256	NUM
dti-1305	806	16	/tileheight	/tileheight	NUM
dti-1305	806	17	256	256	NUM
dti-1305	806	18	/quality	/quality	NOUN
dti-1305	806	19	30	30	NUM
dti-1305	806	20	>	>	PUNCT
dti-1305	806	21	>	>	X
dti-1305	806	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1305	806	23	false	false	ADJ
dti-1305	806	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1305	806	25	true	true	ADJ
dti-1305	806	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1305	806	27	/bicubic	/bicubic	NOUN
dti-1305	806	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1305	806	29	1200	1200	NUM
dti-1305	806	30	/monoimagedepth	/monoimagedepth	PRON
dti-1305	806	31	-1	-1	PUNCT
dti-1305	806	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1305	806	33	1.50000	1.50000	NUM
dti-1305	806	34	/encodemonoimages	/encodemonoimage	NOUN
dti-1305	806	35	true	true	ADJ
dti-1305	806	36	/monoimagefilter	/monoimagefilter	ADP
dti-1305	806	37	/ccittfaxencode	/ccittfaxencode	INTJ
dti-1305	806	38	/monoimagedict	/monoimagedict	PUNCT
dti-1305	807	1	<	<	X
dti-1305	807	2	<	<	X
dti-1305	807	3	/k	/k	PUNCT
dti-1305	807	4	-1	-1	INTJ
dti-1305	807	5	>	>	PUNCT
dti-1305	807	6	>	>	X
dti-1305	807	7	/allowpsxobjects	/allowpsxobject	NOUN
dti-1305	808	1	false	false	ADJ
dti-1305	808	2	/pdfx1acheck	/pdfx1acheck	X
dti-1305	808	3	false	false	ADJ
dti-1305	808	4	/pdfx3check	/pdfx3check	PUNCT
dti-1305	808	5	false	false	ADJ
dti-1305	808	6	/pdfxcompliantpdfonly	/pdfxcompliantpdfonly	ADV
dti-1305	808	7	false	false	ADJ
dti-1305	808	8	/pdfxnotrimboxerror	/pdfxnotrimboxerror	NOUN
dti-1305	808	9	true	true	ADJ
dti-1305	808	10	/pdfxtrimboxtomediaboxoffset	/pdfxtrimboxtomediaboxoffset	NOUN
dti-1305	808	11	[	[	PUNCT
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