id	sid	tid	token	lemma	pos
dti-1306	1	1	ningaraj	ningaraj	PROPN
dti-1306	1	2	et	et	PROPN
dti-1306	1	3	al.indd	al.indd	X
dti-1306	1	4	drug	drug	NOUN
dti-1306	1	5	target	target	NOUN
dti-1306	1	6	insights	insight	NOUN
dti-1306	1	7	2007	2007	NUM
dti-1306	1	8	:	:	PUNCT
dti-1306	1	9	2	2	NUM
dti-1306	1	10	197–207	197–207	NUM
dti-1306	1	11	197	197	NUM
dti-1306	1	12	review	review	NOUN
dti-1306	1	13	correspondence	correspondence	NOUN
dti-1306	1	14	:	:	PUNCT
dti-1306	2	1	ningaraj	ningaraj	PROPN
dti-1306	2	2	,	,	PUNCT
dti-1306	2	3	n.s	n.s	PROPN
dti-1306	2	4	.	.	PROPN
dti-1306	2	5	,	,	PUNCT
dti-1306	2	6	department	department	NOUN
dti-1306	2	7	of	of	ADP
dti-1306	2	8	pediatric	pediatric	ADJ
dti-1306	2	9	neurooncology	neurooncology	NOUN
dti-1306	2	10	and	and	CCONJ
dti-1306	2	11	molecular	molecular	ADJ
dti-1306	2	12	pharmacology	pharmacology	NOUN
dti-1306	2	13	,	,	PUNCT
dti-1306	2	14	hoskins	hoskin	NOUN
dti-1306	2	15	center	center	NOUN
dti-1306	2	16	,	,	PUNCT
dti-1306	2	17	curtis	curtis	PROPN
dti-1306	2	18	and	and	CCONJ
dti-1306	2	19	elizabeth	elizabeth	PROPN
dti-1306	2	20	anderson	anderson	PROPN
dti-1306	2	21	cancer	cancer	PROPN
dti-1306	2	22	institute	institute	PROPN
dti-1306	2	23	,	,	PUNCT
dti-1306	2	24	memorial	memorial	ADJ
dti-1306	2	25	health	health	PROPN
dti-1306	2	26	university	university	PROPN
dti-1306	2	27	medical	medical	ADJ
dti-1306	2	28	center	center	NOUN
dti-1306	2	29	,	,	PUNCT
dti-1306	2	30	mercer	mercer	PROPN
dti-1306	2	31	university	university	PROPN
dti-1306	2	32	medical	medical	ADJ
dti-1306	2	33	school	school	NOUN
dti-1306	2	34	,	,	PUNCT
dti-1306	2	35	4700	4700	NUM
dti-1306	2	36	waters	water	VERB
dti-1306	2	37	avenue	avenue	PROPN
dti-1306	2	38	,	,	PUNCT
dti-1306	2	39	savannah	savannah	PROPN
dti-1306	2	40	,	,	PUNCT
dti-1306	2	41	ga	ga	PROPN
dti-1306	2	42	31404	31404	NUM
dti-1306	2	43	,	,	PUNCT
dti-1306	2	44	u.s.a.tel	u.s.a.tel	NOUN
dti-1306	2	45	:	:	PUNCT
dti-1306	2	46	+1	+1	PROPN
dti-1306	2	47	9123500958	9123500958	NUM
dti-1306	2	48	;	;	PUNCT
dti-1306	2	49	fax	fax	NOUN
dti-1306	2	50	:	:	PUNCT
dti-1306	2	51	+1	+1	PROPN
dti-1306	2	52	9123501269	9123501269	NUM
dti-1306	2	53	;	;	PUNCT
dti-1306	2	54	email	email	NOUN
dti-1306	2	55	:	:	PUNCT
dti-1306	2	56	ningana1@memorialhealth.com	ningana1@memorialhealth.com	X
dti-1306	2	57	please	please	INTJ
dti-1306	2	58	note	note	VERB
dti-1306	2	59	that	that	SCONJ
dti-1306	2	60	this	this	DET
dti-1306	2	61	article	article	NOUN
dti-1306	2	62	may	may	AUX
dti-1306	2	63	not	not	PART
dti-1306	2	64	be	be	AUX
dti-1306	2	65	used	use	VERB
dti-1306	2	66	for	for	ADP
dti-1306	2	67	commercial	commercial	ADJ
dti-1306	2	68	purposes	purpose	NOUN
dti-1306	2	69	.	.	PUNCT
dti-1306	3	1	for	for	ADP
dti-1306	3	2	further	further	ADJ
dti-1306	3	3	information	information	NOUN
dti-1306	3	4	please	please	INTJ
dti-1306	3	5	refer	refer	VERB
dti-1306	3	6	to	to	ADP
dti-1306	3	7	the	the	DET
dti-1306	3	8	copyright	copyright	NOUN
dti-1306	3	9	statement	statement	NOUN
dti-1306	3	10	at	at	ADP
dti-1306	3	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1306	3	12	targeted	target	VERB
dti-1306	3	13	brain	brain	NOUN
dti-1306	3	14	tumor	tumor	NOUN
dti-1306	3	15	treatment	treatment	NOUN
dti-1306	3	16	-	-	PUNCT
dti-1306	3	17	current	current	ADJ
dti-1306	3	18	perspectives	perspective	NOUN
dti-1306	3	19	ningaraj	ningaraj	ADJ
dti-1306	3	20	n.s1	n.s1	ADJ
dti-1306	3	21	,	,	PUNCT
dti-1306	3	22	salimath	salimath	NOUN
dti-1306	3	23	b.p2	b.p2	ADV
dti-1306	3	24	,	,	PUNCT
dti-1306	3	25	sankpal	sankpal	ADJ
dti-1306	3	26	u.t1	u.t1	NOUN
dti-1306	3	27	,	,	PUNCT
dti-1306	3	28	perera	perera	PROPN
dti-1306	3	29	r1	r1	PROPN
dti-1306	3	30	and	and	CCONJ
dti-1306	3	31	vats	vat	NOUN
dti-1306	3	32	t1	t1	VERB
dti-1306	3	33	1department	1department	NUM
dti-1306	3	34	of	of	ADP
dti-1306	3	35	pediatric	pediatric	ADJ
dti-1306	3	36	neurooncology	neurooncology	NOUN
dti-1306	3	37	and	and	CCONJ
dti-1306	3	38	molecular	molecular	ADJ
dti-1306	3	39	pharmacology	pharmacology	NOUN
dti-1306	3	40	,	,	PUNCT
dti-1306	3	41	hoskins	hoskin	NOUN
dti-1306	3	42	center	center	NOUN
dti-1306	3	43	,	,	PUNCT
dti-1306	3	44	curtis	curtis	PROPN
dti-1306	3	45	and	and	CCONJ
dti-1306	3	46	elizabeth	elizabeth	PROPN
dti-1306	3	47	anderson	anderson	PROPN
dti-1306	3	48	cancer	cancer	PROPN
dti-1306	3	49	institute	institute	PROPN
dti-1306	3	50	,	,	PUNCT
dti-1306	3	51	memorial	memorial	ADJ
dti-1306	3	52	health	health	PROPN
dti-1306	3	53	university	university	PROPN
dti-1306	3	54	medical	medical	ADJ
dti-1306	3	55	center	center	NOUN
dti-1306	3	56	,	,	PUNCT
dti-1306	3	57	mercer	mercer	PROPN
dti-1306	3	58	university	university	PROPN
dti-1306	3	59	medical	medical	ADJ
dti-1306	3	60	school	school	NOUN
dti-1306	3	61	,	,	PUNCT
dti-1306	3	62	4700	4700	NUM
dti-1306	3	63	waters	water	VERB
dti-1306	3	64	avenue	avenue	PROPN
dti-1306	3	65	,	,	PUNCT
dti-1306	3	66	savannah	savannah	PROPN
dti-1306	3	67	,	,	PUNCT
dti-1306	3	68	ga	ga	PROPN
dti-1306	3	69	31404	31404	NUM
dti-1306	3	70	,	,	PUNCT
dti-1306	3	71	u.s.a	u.s.a	NOUN
dti-1306	3	72	.	.	PUNCT
dti-1306	4	1	2department	2department	NUM
dti-1306	4	2	of	of	ADP
dti-1306	4	3	biotechnology	biotechnology	NOUN
dti-1306	4	4	,	,	PUNCT
dti-1306	4	5	university	university	NOUN
dti-1306	4	6	of	of	ADP
dti-1306	4	7	mysore	mysore	NOUN
dti-1306	4	8	,	,	PUNCT
dti-1306	4	9	mysore	mysore	NOUN
dti-1306	4	10	570006	570006	NUM
dti-1306	4	11	,	,	PUNCT
dti-1306	4	12	karnataka	karnataka	PROPN
dti-1306	4	13	,	,	PUNCT
dti-1306	4	14	india	india	PROPN
dti-1306	4	15	.	.	PUNCT
dti-1306	5	1	abstract	abstract	ADJ
dti-1306	5	2	:	:	PUNCT
dti-1306	5	3	brain	brain	NOUN
dti-1306	5	4	tumor	tumor	NOUN
dti-1306	5	5	is	be	AUX
dti-1306	5	6	associated	associate	VERB
dti-1306	5	7	with	with	ADP
dti-1306	5	8	poor	poor	ADJ
dti-1306	5	9	prognosis	prognosis	NOUN
dti-1306	5	10	.	.	PUNCT
dti-1306	6	1	the	the	DET
dti-1306	6	2	treatment	treatment	NOUN
dti-1306	6	3	option	option	NOUN
dti-1306	6	4	is	be	AUX
dti-1306	6	5	severely	severely	ADV
dti-1306	6	6	limited	limit	VERB
dti-1306	6	7	for	for	ADP
dti-1306	6	8	a	a	DET
dti-1306	6	9	patient	patient	NOUN
dti-1306	6	10	with	with	ADP
dti-1306	6	11	brain	brain	NOUN
dti-1306	6	12	tumor	tumor	NOUN
dti-1306	6	13	,	,	PUNCT
dti-1306	6	14	despite	despite	SCONJ
dti-1306	6	15	great	great	ADJ
dti-1306	6	16	advances	advance	NOUN
dti-1306	6	17	in	in	ADP
dti-1306	6	18	understanding	understand	VERB
dti-1306	6	19	the	the	DET
dti-1306	6	20	etiology	etiology	NOUN
dti-1306	6	21	and	and	CCONJ
dti-1306	6	22	molecular	molecular	ADJ
dti-1306	6	23	biology	biology	NOUN
dti-1306	6	24	of	of	ADP
dti-1306	6	25	brain	brain	NOUN
dti-1306	6	26	tumors	tumor	NOUN
dti-1306	6	27	that	that	PRON
dti-1306	6	28	have	have	AUX
dti-1306	6	29	lead	lead	VERB
dti-1306	6	30	to	to	ADP
dti-1306	6	31	breakthroughs	breakthrough	NOUN
dti-1306	6	32	in	in	ADP
dti-1306	6	33	developing	develop	VERB
dti-1306	6	34	pharmaceutical	pharmaceutical	ADJ
dti-1306	6	35	strategies	strategy	NOUN
dti-1306	6	36	,	,	PUNCT
dti-1306	6	37	and	and	CCONJ
dti-1306	6	38	ongoing	ongoing	ADJ
dti-1306	6	39	nci	nci	PROPN
dti-1306	6	40	/	/	SYM
dti-1306	6	41	pharma	pharma	NOUN
dti-1306	6	42	-	-	PUNCT
dti-1306	6	43	sponsored	sponsor	VERB
dti-1306	6	44	clinical	clinical	ADJ
dti-1306	6	45	trials	trial	NOUN
dti-1306	6	46	.	.	PUNCT
dti-1306	7	1	we	we	PRON
dti-1306	7	2	reviewed	review	VERB
dti-1306	7	3	the	the	DET
dti-1306	7	4	literature	literature	NOUN
dti-1306	7	5	on	on	ADP
dti-1306	7	6	molecular	molecular	ADJ
dti-1306	7	7	targeted	target	VERB
dti-1306	7	8	agents	agent	NOUN
dti-1306	7	9	in	in	ADP
dti-1306	7	10	preclinical	preclinical	ADJ
dti-1306	7	11	and	and	CCONJ
dti-1306	7	12	clinical	clinical	ADJ
dti-1306	7	13	studies	study	NOUN
dti-1306	7	14	in	in	ADP
dti-1306	7	15	brain	brain	NOUN
dti-1306	7	16	tumor	tumor	NOUN
dti-1306	7	17	for	for	ADP
dti-1306	7	18	the	the	DET
dti-1306	7	19	past	past	ADJ
dti-1306	7	20	decade	decade	NOUN
dti-1306	7	21	,	,	PUNCT
dti-1306	7	22	and	and	CCONJ
dti-1306	7	23	observed	observe	VERB
dti-1306	7	24	that	that	SCONJ
dti-1306	7	25	the	the	DET
dti-1306	7	26	molecular	molecular	NOUN
dti-1306	7	27	targeting	target	VERB
dti-1306	7	28	in	in	ADP
dti-1306	7	29	brain	brain	NOUN
dti-1306	7	30	tumors	tumor	NOUN
dti-1306	7	31	is	be	AUX
dti-1306	7	32	complex	complex	ADJ
dti-1306	7	33	.	.	PUNCT
dti-1306	8	1	this	this	PRON
dti-1306	8	2	is	be	AUX
dti-1306	8	3	because	because	SCONJ
dti-1306	8	4	no	no	DET
dti-1306	8	5	single	single	ADJ
dti-1306	8	6	gene	gene	NOUN
dti-1306	8	7	or	or	CCONJ
dti-1306	8	8	protein	protein	NOUN
dti-1306	8	9	can	can	AUX
dti-1306	8	10	be	be	AUX
dti-1306	8	11	affected	affect	VERB
dti-1306	8	12	by	by	ADP
dti-1306	8	13	single	single	ADJ
dti-1306	8	14	molecular	molecular	ADJ
dti-1306	8	15	agent	agent	NOUN
dti-1306	8	16	,	,	PUNCT
dti-1306	8	17	requiring	require	VERB
dti-1306	8	18	the	the	DET
dti-1306	8	19	use	use	NOUN
dti-1306	8	20	of	of	ADP
dti-1306	8	21	combination	combination	NOUN
dti-1306	8	22	molecular	molecular	ADJ
dti-1306	8	23	therapy	therapy	NOUN
dti-1306	8	24	with	with	ADP
dti-1306	8	25	cytotoxic	cytotoxic	ADJ
dti-1306	8	26	agents	agent	NOUN
dti-1306	8	27	.	.	PUNCT
dti-1306	9	1	in	in	ADP
dti-1306	9	2	this	this	DET
dti-1306	9	3	review	review	NOUN
dti-1306	9	4	,	,	PUNCT
dti-1306	9	5	we	we	PRON
dti-1306	9	6	briefl	briefl	VERB
dti-1306	9	7	y	y	PRON
dti-1306	9	8	discuss	discuss	VERB
dti-1306	9	9	the	the	DET
dti-1306	9	10	potential	potential	ADJ
dti-1306	9	11	molecular	molecular	ADJ
dti-1306	9	12	targets	target	NOUN
dti-1306	9	13	,	,	PUNCT
dti-1306	9	14	and	and	CCONJ
dti-1306	9	15	the	the	DET
dti-1306	9	16	challenges	challenge	NOUN
dti-1306	9	17	of	of	ADP
dti-1306	9	18	targeted	target	VERB
dti-1306	9	19	brain	brain	NOUN
dti-1306	9	20	tumor	tumor	NOUN
dti-1306	9	21	treatment	treatment	NOUN
dti-1306	9	22	.	.	PUNCT
dti-1306	10	1	for	for	ADP
dti-1306	10	2	example	example	NOUN
dti-1306	10	3	,	,	PUNCT
dti-1306	10	4	glial	glial	ADJ
dti-1306	10	5	tumors	tumor	NOUN
dti-1306	10	6	are	be	AUX
dti-1306	10	7	associated	associate	VERB
dti-1306	10	8	with	with	ADP
dti-1306	10	9	over	over	ADP
dti-1306	10	10	-	-	PUNCT
dti-1306	10	11	expression	expression	NOUN
dti-1306	10	12	of	of	ADP
dti-1306	10	13	calcium	calcium	NOUN
dti-1306	10	14	-	-	PUNCT
dti-1306	10	15	dependent	dependent	ADJ
dti-1306	10	16	potassium	potassium	NOUN
dti-1306	10	17	(	(	PUNCT
dti-1306	10	18	kca	kca	PROPN
dti-1306	10	19	)	)	PUNCT
dti-1306	10	20	channels	channel	NOUN
dti-1306	10	21	,	,	PUNCT
dti-1306	10	22	and	and	CCONJ
dti-1306	10	23	high	high	ADJ
dti-1306	10	24	grade	grade	NOUN
dti-1306	10	25	glioma	glioma	NOUN
dti-1306	10	26	express	express	VERB
dti-1306	10	27	specifi	specifi	PROPN
dti-1306	10	28	c	c	PROPN
dti-1306	10	29	kca	kca	PROPN
dti-1306	10	30	channel	channel	PROPN
dti-1306	10	31	gene	gene	NOUN
dti-1306	10	32	(	(	PUNCT
dti-1306	10	33	gbk	gbk	NOUN
dti-1306	10	34	)	)	PUNCT
dti-1306	10	35	splice	splice	NOUN
dti-1306	10	36	variants	variant	NOUN
dti-1306	10	37	,	,	PUNCT
dti-1306	10	38	and	and	CCONJ
dti-1306	10	39	mutant	mutant	ADJ
dti-1306	10	40	epidermal	epidermal	ADJ
dti-1306	10	41	growth	growth	NOUN
dti-1306	10	42	factor	factor	NOUN
dti-1306	10	43	receptors	receptor	NOUN
dti-1306	10	44	(	(	PUNCT
dti-1306	10	45	egfrviii	egfrviii	PROPN
dti-1306	10	46	)	)	PUNCT
dti-1306	10	47	.	.	PUNCT
dti-1306	11	1	these	these	DET
dti-1306	11	2	specifi	specifi	PROPN
dti-1306	11	3	c	c	PROPN
dti-1306	11	4	genes	gene	NOUN
dti-1306	11	5	are	be	AUX
dti-1306	11	6	promising	promise	VERB
dti-1306	11	7	targets	target	NOUN
dti-1306	11	8	for	for	ADP
dti-1306	11	9	molecular	molecular	ADJ
dti-1306	11	10	targeted	target	VERB
dti-1306	11	11	treatment	treatment	NOUN
dti-1306	11	12	in	in	ADP
dti-1306	11	13	brain	brain	NOUN
dti-1306	11	14	tumors	tumor	NOUN
dti-1306	11	15	.	.	PUNCT
dti-1306	12	1	in	in	ADP
dti-1306	12	2	addition	addition	NOUN
dti-1306	12	3	,	,	PUNCT
dti-1306	12	4	drugs	drug	NOUN
dti-1306	12	5	like	like	ADP
dti-1306	12	6	avastin	avastin	PROPN
dti-1306	12	7	and	and	CCONJ
dti-1306	12	8	gleevec	gleevec	PROPN
dti-1306	12	9	target	target	VERB
dti-1306	12	10	the	the	DET
dti-1306	12	11	molecular	molecular	ADJ
dti-1306	12	12	targets	target	NOUN
dti-1306	12	13	such	such	ADJ
dti-1306	12	14	as	as	ADP
dti-1306	12	15	vascular	vascular	ADJ
dti-1306	12	16	endothelial	endothelial	NOUN
dti-1306	12	17	cell	cell	NOUN
dti-1306	12	18	growth	growth	NOUN
dti-1306	12	19	factor	factor	NOUN
dti-1306	12	20	receptor	receptor	NOUN
dti-1306	12	21	,	,	PUNCT
dti-1306	12	22	platelet	platelet	NOUN
dti-1306	12	23	-	-	PUNCT
dti-1306	12	24	derived	derive	VERB
dti-1306	12	25	growth	growth	NOUN
dti-1306	12	26	factor	factor	NOUN
dti-1306	12	27	receptors	receptor	NOUN
dti-1306	12	28	,	,	PUNCT
dti-1306	12	29	and	and	CCONJ
dti-1306	12	30	brc	brc	PROPN
dti-1306	12	31	-	-	PUNCT
dti-1306	12	32	abl	abl	PROPN
dti-1306	12	33	/	/	SYM
dti-1306	12	34	akt	akt	PROPN
dti-1306	12	35	.	.	PUNCT
dti-1306	13	1	recent	recent	ADJ
dti-1306	13	2	discovery	discovery	NOUN
dti-1306	13	3	of	of	ADP
dti-1306	13	4	non	non	ADJ
dti-1306	13	5	-	-	ADJ
dti-1306	13	6	coding	code	VERB
dti-1306	13	7	rna	rna	NOUN
dti-1306	13	8	,	,	PUNCT
dti-1306	13	9	specifi	specifi	PROPN
dti-1306	13	10	cally	cally	ADV
dti-1306	13	11	micrornas	microrna	NOUN
dti-1306	13	12	could	could	AUX
dti-1306	13	13	be	be	AUX
dti-1306	13	14	used	use	VERB
dti-1306	13	15	as	as	ADP
dti-1306	13	16	potential	potential	ADJ
dti-1306	13	17	targeted	target	VERB
dti-1306	13	18	drugs	drug	NOUN
dti-1306	13	19	.	.	PUNCT
dti-1306	14	1	finally	finally	ADV
dti-1306	14	2	,	,	PUNCT
dti-1306	14	3	we	we	PRON
dti-1306	14	4	discuss	discuss	VERB
dti-1306	14	5	the	the	DET
dti-1306	14	6	role	role	NOUN
dti-1306	14	7	of	of	ADP
dti-1306	14	8	anti	anti	ADJ
dti-1306	14	9	-	-	ADJ
dti-1306	14	10	cancer	cancer	ADJ
dti-1306	14	11	drug	drug	NOUN
dti-1306	14	12	delivery	delivery	NOUN
dti-1306	14	13	to	to	ADP
dti-1306	14	14	brain	brain	NOUN
dti-1306	14	15	tumors	tumor	NOUN
dti-1306	14	16	by	by	ADP
dti-1306	14	17	breaching	breach	VERB
dti-1306	14	18	the	the	DET
dti-1306	14	19	blood	blood	NOUN
dti-1306	14	20	-	-	PUNCT
dti-1306	14	21	brain	brain	NOUN
dti-1306	14	22	tumor	tumor	NOUN
dti-1306	14	23	barrier	barrier	NOUN
dti-1306	14	24	.	.	PUNCT
dti-1306	15	1	this	this	DET
dti-1306	15	2	non	non	ADJ
dti-1306	15	3	-	-	ADJ
dti-1306	15	4	invasive	invasive	ADJ
dti-1306	15	5	strategy	strategy	NOUN
dti-1306	15	6	is	be	AUX
dti-1306	15	7	particularly	particularly	ADV
dti-1306	15	8	useful	useful	ADJ
dti-1306	15	9	as	as	ADP
dti-1306	15	10	novel	novel	ADJ
dti-1306	15	11	molecules	molecule	NOUN
dti-1306	15	12	and	and	CCONJ
dti-1306	15	13	humanized	humanize	VERB
dti-1306	15	14	monoclonal	monoclonal	NOUN
dti-1306	15	15	antibodies	antibodie	VERB
dti-1306	15	16	that	that	PRON
dti-1306	15	17	target	target	VERB
dti-1306	15	18	receptor	receptor	NOUN
dti-1306	15	19	tyrosine	tyrosine	PROPN
dti-1306	15	20	kinase	kinase	PROPN
dti-1306	15	21	receptors	receptor	NOUN
dti-1306	15	22	are	be	AUX
dti-1306	15	23	rapidly	rapidly	ADV
dti-1306	15	24	being	be	AUX
dti-1306	15	25	developed	develop	VERB
dti-1306	15	26	.	.	PUNCT
dti-1306	16	1	abbreviations	abbreviation	NOUN
dti-1306	16	2	:	:	PUNCT
dti-1306	17	1	bbb	bbb	NUM
dti-1306	17	2	:	:	PUNCT
dti-1306	17	3	blood	blood	NOUN
dti-1306	17	4	-	-	PUNCT
dti-1306	17	5	brain	brain	NOUN
dti-1306	17	6	barrier	barrier	NOUN
dti-1306	17	7	;	;	PUNCT
dti-1306	17	8	btb	btb	ADP
dti-1306	17	9	:	:	PUNCT
dti-1306	17	10	blood	blood	NOUN
dti-1306	17	11	-	-	PUNCT
dti-1306	17	12	tumor	tumor	NOUN
dti-1306	17	13	barrier	barrier	NOUN
dti-1306	17	14	;	;	PUNCT
dti-1306	17	15	kca	kca	PROPN
dti-1306	17	16	:	:	PUNCT
dti-1306	17	17	calcium	calcium	NOUN
dti-1306	17	18	-	-	PUNCT
dti-1306	17	19	dependent	dependent	ADJ
dti-1306	17	20	potassium	potassium	NOUN
dti-1306	17	21	channels	channel	NOUN
dti-1306	17	22	;	;	PUNCT
dti-1306	17	23	ns-1619/	ns-1619/	X
dti-1306	17	24	ns	ns	NUM
dti-1306	17	25	004	004	NUM
dti-1306	17	26	:	:	PUNCT
dti-1306	17	27	1,3	1,3	NUM
dti-1306	17	28	-	-	PUNCT
dti-1306	17	29	dihydro-1	dihydro-1	NOUN
dti-1306	17	30	-	-	PROPN
dti-1306	17	31	5-(trifl	5-(trifl	NUM
dti-1306	17	32	uoromethyl)-2h	uoromethyl)-2h	ADJ
dti-1306	17	33	benzimidazol-2	benzimidazol-2	PROPN
dti-1306	17	34	-	-	PUNCT
dti-1306	17	35	one	one	NUM
dti-1306	17	36	;	;	PUNCT
dti-1306	17	37	hbmvec	hbmvec	NOUN
dti-1306	17	38	:	:	PUNCT
dti-1306	17	39	human	human	ADJ
dti-1306	17	40	brain	brain	NOUN
dti-1306	17	41	microvascular	microvascular	NOUN
dti-1306	17	42	endothelial	endothelial	ADJ
dti-1306	17	43	cells	cell	NOUN
dti-1306	17	44	;	;	PUNCT
dti-1306	17	45	facs	fac	NOUN
dti-1306	17	46	:	:	PUNCT
dti-1306	17	47	fl	fl	NUM
dti-1306	17	48	uorescence	uorescence	VERB
dti-1306	17	49	activated	activate	VERB
dti-1306	17	50	cell	cell	NOUN
dti-1306	17	51	sorting	sorting	NOUN
dti-1306	17	52	;	;	PUNCT
dti-1306	17	53	pdgfr	pdgfr	ADJ
dti-1306	17	54	:	:	PUNCT
dti-1306	17	55	platelet	platelet	ADJ
dti-1306	17	56	-	-	PUNCT
dti-1306	17	57	derived	derive	VERB
dti-1306	17	58	growth	growth	NOUN
dti-1306	17	59	factor	factor	NOUN
dti-1306	17	60	receptor	receptor	NOUN
dti-1306	17	61	;	;	PUNCT
dti-1306	17	62	rtkis	rtki	NOUN
dti-1306	17	63	:	:	PUNCT
dti-1306	17	64	receptor	receptor	NOUN
dti-1306	17	65	tyrosine	tyrosine	PROPN
dti-1306	17	66	kinase	kinase	PROPN
dti-1306	17	67	inhibitors	inhibitor	NOUN
dti-1306	17	68	;	;	PUNCT
dti-1306	17	69	egfr	egfr	ADJ
dti-1306	17	70	:	:	PUNCT
dti-1306	17	71	epidermal	epidermal	ADJ
dti-1306	17	72	growth	growth	NOUN
dti-1306	17	73	factor	factor	NOUN
dti-1306	17	74	receptor	receptor	NOUN
dti-1306	17	75	;	;	PUNCT
dti-1306	17	76	egfrviii	egfrviii	NOUN
dti-1306	17	77	:	:	PUNCT
dti-1306	17	78	variant	variant	NOUN
dti-1306	17	79	iii	iii	NOUN
dti-1306	17	80	of	of	ADP
dti-1306	17	81	the	the	DET
dti-1306	17	82	human	human	ADJ
dti-1306	17	83	egfr	egfr	NOUN
dti-1306	17	84	;	;	PUNCT
dti-1306	17	85	gbk	gbk	PROPN
dti-1306	17	86	channel	channel	PROPN
dti-1306	17	87	:	:	PUNCT
dti-1306	17	88	glioma	glioma	NOUN
dti-1306	17	89	specifi	specifi	PROPN
dti-1306	17	90	c	c	PROPN
dti-1306	17	91	spice	spice	PROPN
dti-1306	17	92	variant	variant	NOUN
dti-1306	17	93	of	of	ADP
dti-1306	17	94	kca	kca	PROPN
dti-1306	17	95	channel	channel	PROPN
dti-1306	17	96	gene	gene	NOUN
dti-1306	17	97	;	;	PUNCT
dti-1306	17	98	katp	katp	NOUN
dti-1306	17	99	:	:	PUNCT
dti-1306	17	100	atp	atp	PROPN
dti-1306	17	101	sensitive	sensitive	ADJ
dti-1306	17	102	potassium	potassium	NOUN
dti-1306	17	103	channels	channel	NOUN
dti-1306	17	104	;	;	PUNCT
dti-1306	17	105	minoxidil	minoxidil	ADJ
dti-1306	17	106	sulfate	sulfate	NOUN
dti-1306	17	107	(	(	PUNCT
dti-1306	17	108	ms	ms	NOUN
dti-1306	17	109	:	:	PUNCT
dti-1306	17	110	katp	katp	PROPN
dti-1306	17	111	channel	channel	NOUN
dti-1306	17	112	agonist	agonist	NOUN
dti-1306	17	113	)	)	PUNCT
dti-1306	17	114	;	;	PUNCT
dti-1306	17	115	trastuzumab	trastuzumab	NOUN
dti-1306	17	116	(	(	PUNCT
dti-1306	17	117	herceptin	herceptin	PROPN
dti-1306	17	118	,	,	PUNCT
dti-1306	17	119	her-2	her-2	NUM
dti-1306	17	120	inhibitor	inhibitor	NOUN
dti-1306	17	121	,	,	PUNCT
dti-1306	17	122	genentech	genentech	PROPN
dti-1306	17	123	inc	inc	PROPN
dti-1306	17	124	.	.	PROPN
dti-1306	17	125	)	)	PUNCT
dti-1306	17	126	.	.	PUNCT
dti-1306	18	1	keywords	keyword	NOUN
dti-1306	18	2	:	:	PUNCT
dti-1306	18	3	brain	brain	NOUN
dti-1306	18	4	tumor	tumor	NOUN
dti-1306	18	5	,	,	PUNCT
dti-1306	18	6	bbb	bbb	PROPN
dti-1306	18	7	,	,	PUNCT
dti-1306	18	8	drug	drug	NOUN
dti-1306	18	9	delivery	delivery	NOUN
dti-1306	18	10	,	,	PUNCT
dti-1306	18	11	therapeutic	therapeutic	ADJ
dti-1306	18	12	targets	target	NOUN
dti-1306	18	13	in	in	ADP
dti-1306	18	14	brain	brain	NOUN
dti-1306	18	15	tumors	tumor	NOUN
dti-1306	18	16	introduction	introduction	NOUN
dti-1306	18	17	brain	brain	NOUN
dti-1306	18	18	tumor	tumor	NOUN
dti-1306	18	19	nearly	nearly	ADV
dti-1306	18	20	20,000	20,000	NUM
dti-1306	18	21	new	new	ADJ
dti-1306	18	22	primary	primary	ADJ
dti-1306	18	23	brain	brain	NOUN
dti-1306	18	24	tumors	tumor	NOUN
dti-1306	18	25	and	and	CCONJ
dti-1306	18	26	about	about	ADV
dti-1306	18	27	200,000	200,000	NUM
dti-1306	18	28	metastatic	metastatic	ADJ
dti-1306	18	29	brain	brain	NOUN
dti-1306	18	30	tumor	tumor	NOUN
dti-1306	18	31	cases	case	NOUN
dti-1306	18	32	are	be	AUX
dti-1306	18	33	reported	report	VERB
dti-1306	18	34	each	each	DET
dti-1306	18	35	year	year	NOUN
dti-1306	18	36	in	in	ADP
dti-1306	18	37	the	the	DET
dti-1306	18	38	u.s.a	u.s.a	NOUN
dti-1306	18	39	.	.	PUNCT
dti-1306	19	1	(	(	PUNCT
dti-1306	19	2	levin	levin	PROPN
dti-1306	19	3	,	,	PUNCT
dti-1306	19	4	2007	2007	NUM
dti-1306	19	5	)	)	PUNCT
dti-1306	19	6	.	.	PUNCT
dti-1306	20	1	the	the	DET
dti-1306	20	2	overall	overall	ADJ
dti-1306	20	3	survival	survival	NOUN
dti-1306	20	4	of	of	ADP
dti-1306	20	5	these	these	DET
dti-1306	20	6	patients	patient	NOUN
dti-1306	20	7	is	be	AUX
dti-1306	20	8	dismal	dismal	ADJ
dti-1306	20	9	and	and	CCONJ
dti-1306	20	10	the	the	DET
dti-1306	20	11	majority	majority	NOUN
dti-1306	20	12	of	of	ADP
dti-1306	20	13	survivors	survivor	NOUN
dti-1306	20	14	suffer	suffer	VERB
dti-1306	20	15	disabling	disable	VERB
dti-1306	20	16	toxicities	toxicity	NOUN
dti-1306	20	17	from	from	ADP
dti-1306	20	18	their	their	PRON
dti-1306	20	19	treatments	treatment	NOUN
dti-1306	20	20	.	.	PUNCT
dti-1306	21	1	standard	standard	ADJ
dti-1306	21	2	treatment	treatment	NOUN
dti-1306	21	3	for	for	ADP
dti-1306	21	4	brain	brain	NOUN
dti-1306	21	5	tumors	tumor	NOUN
dti-1306	21	6	includes	include	VERB
dti-1306	21	7	combination	combination	NOUN
dti-1306	21	8	of	of	ADP
dti-1306	21	9	surgery	surgery	NOUN
dti-1306	21	10	,	,	PUNCT
dti-1306	21	11	radiation	radiation	NOUN
dti-1306	21	12	therapy	therapy	NOUN
dti-1306	21	13	,	,	PUNCT
dti-1306	21	14	and	and	CCONJ
dti-1306	21	15	chemotherapy	chemotherapy	NOUN
dti-1306	21	16	.	.	PUNCT
dti-1306	22	1	brain	brain	NOUN
dti-1306	22	2	tumor	tumor	NOUN
dti-1306	22	3	poses	pose	VERB
dti-1306	22	4	unique	unique	ADJ
dti-1306	22	5	challenges	challenge	NOUN
dti-1306	22	6	due	due	ADP
dti-1306	22	7	to	to	ADP
dti-1306	22	8	its	its	PRON
dti-1306	22	9	distinct	distinct	ADJ
dti-1306	22	10	biology	biology	NOUN
dti-1306	22	11	,	,	PUNCT
dti-1306	22	12	genetics	genetic	NOUN
dti-1306	22	13	,	,	PUNCT
dti-1306	22	14	treatment	treatment	NOUN
dti-1306	22	15	response	response	NOUN
dti-1306	22	16	,	,	PUNCT
dti-1306	22	17	and	and	CCONJ
dti-1306	22	18	survival	survival	NOUN
dti-1306	22	19	.	.	PUNCT
dti-1306	23	1	despite	despite	SCONJ
dti-1306	23	2	extensive	extensive	ADJ
dti-1306	23	3	characterization	characterization	NOUN
dti-1306	23	4	of	of	ADP
dti-1306	23	5	the	the	DET
dti-1306	23	6	brain	brain	NOUN
dti-1306	23	7	tumor	tumor	NOUN
dti-1306	23	8	pathways	pathway	NOUN
dti-1306	23	9	,	,	PUNCT
dti-1306	23	10	molecularly	molecularly	ADV
dti-1306	23	11	targeted	target	VERB
dti-1306	23	12	approach	approach	NOUN
dti-1306	23	13	is	be	AUX
dti-1306	23	14	not	not	PART
dti-1306	23	15	available	available	ADJ
dti-1306	23	16	to	to	PART
dti-1306	23	17	brain	brain	VERB
dti-1306	23	18	tumor	tumor	NOUN
dti-1306	23	19	patients	patient	NOUN
dti-1306	23	20	.	.	PUNCT
dti-1306	24	1	future	future	ADJ
dti-1306	24	2	research	research	NOUN
dti-1306	24	3	in	in	ADP
dti-1306	24	4	brain	brain	NOUN
dti-1306	24	5	tumors	tumor	NOUN
dti-1306	24	6	needs	need	VERB
dti-1306	24	7	to	to	PART
dti-1306	24	8	focus	focus	VERB
dti-1306	24	9	on	on	ADP
dti-1306	24	10	strategies	strategy	NOUN
dti-1306	24	11	for	for	ADP
dti-1306	24	12	improving	improve	VERB
dti-1306	24	13	drug	drug	NOUN
dti-1306	24	14	delivery	delivery	NOUN
dti-1306	24	15	,	,	PUNCT
dti-1306	24	16	disruption	disruption	NOUN
dti-1306	24	17	of	of	ADP
dti-1306	24	18	blood	blood	NOUN
dti-1306	24	19	-	-	PUNCT
dti-1306	24	20	brain	brain	NOUN
dti-1306	24	21	-	-	PUNCT
dti-1306	24	22	barrier	barrier	NOUN
dti-1306	24	23	(	(	PUNCT
dti-1306	24	24	bbb	bbb	NOUN
dti-1306	24	25	)	)	PUNCT
dti-1306	24	26	,	,	PUNCT
dti-1306	24	27	and	and	CCONJ
dti-1306	24	28	molecular	molecular	ADJ
dti-1306	24	29	profi	profi	NOUN
dti-1306	24	30	ling	ling	NOUN
dti-1306	24	31	of	of	ADP
dti-1306	24	32	tumors	tumor	NOUN
dti-1306	24	33	.	.	PUNCT
dti-1306	25	1	in	in	ADP
dti-1306	25	2	addition	addition	NOUN
dti-1306	25	3	,	,	PUNCT
dti-1306	25	4	careful	careful	ADJ
dti-1306	25	5	studies	study	NOUN
dti-1306	25	6	are	be	AUX
dti-1306	25	7	needed	need	VERB
dti-1306	25	8	to	to	PART
dti-1306	25	9	delineate	delineate	VERB
dti-1306	25	10	pathways	pathway	NOUN
dti-1306	25	11	that	that	PRON
dti-1306	25	12	aid	aid	VERB
dti-1306	25	13	and	and	CCONJ
dti-1306	25	14	abate	abate	VERB
dti-1306	25	15	brain	brain	NOUN
dti-1306	25	16	tumor	tumor	NOUN
dti-1306	25	17	progression	progression	NOUN
dti-1306	25	18	.	.	PUNCT
dti-1306	26	1	identifi	identifi	PROPN
dti-1306	26	2	cation	cation	NOUN
dti-1306	26	3	of	of	ADP
dti-1306	26	4	potential	potential	ADJ
dti-1306	26	5	markers	marker	NOUN
dti-1306	26	6	(	(	PUNCT
dti-1306	26	7	genes	gene	NOUN
dti-1306	26	8	and	and	CCONJ
dti-1306	26	9	proteins	protein	NOUN
dti-1306	26	10	)	)	PUNCT
dti-1306	26	11	for	for	ADP
dti-1306	26	12	targeted	target	VERB
dti-1306	26	13	therapy	therapy	NOUN
dti-1306	26	14	will	will	AUX
dti-1306	26	15	defi	defi	VERB
dti-1306	26	16	nitely	nitely	ADV
dti-1306	26	17	help	help	VERB
dti-1306	26	18	the	the	DET
dti-1306	26	19	clinicians	clinician	NOUN
dti-1306	26	20	to	to	PART
dti-1306	26	21	design	design	VERB
dti-1306	26	22	the	the	DET
dti-1306	26	23	treatment	treatment	NOUN
dti-1306	26	24	accordingly	accordingly	ADV
dti-1306	26	25	.	.	PUNCT
dti-1306	27	1	usually	usually	ADV
dti-1306	27	2	,	,	PUNCT
dti-1306	27	3	after	after	ADP
dti-1306	27	4	surgical	surgical	ADJ
dti-1306	27	5	treatment	treatment	NOUN
dti-1306	27	6	,	,	PUNCT
dti-1306	27	7	brain	brain	NOUN
dti-1306	27	8	tumor	tumor	NOUN
dti-1306	27	9	recurs	recur	NOUN
dti-1306	27	10	,	,	PUNCT
dti-1306	27	11	severely	severely	ADV
dti-1306	27	12	shortening	shorten	VERB
dti-1306	27	13	life	life	NOUN
dti-1306	27	14	expectancy	expectancy	NOUN
dti-1306	27	15	(	(	PUNCT
dti-1306	27	16	friedman	friedman	PROPN
dti-1306	27	17	,	,	PUNCT
dti-1306	27	18	kerby	kerby	PROPN
dti-1306	27	19	and	and	CCONJ
dti-1306	27	20	calvert	calvert	NOUN
dti-1306	27	21	,	,	PUNCT
dti-1306	27	22	2000	2000	NUM
dti-1306	27	23	)	)	PUNCT
dti-1306	27	24	.	.	PUNCT
dti-1306	28	1	conventional	conventional	ADJ
dti-1306	28	2	treatments	treatment	NOUN
dti-1306	28	3	using	use	VERB
dti-1306	28	4	radiation	radiation	NOUN
dti-1306	28	5	and	and	CCONJ
dti-1306	28	6	intravenous	intravenous	ADJ
dti-1306	28	7	chemotherapy	chemotherapy	NOUN
dti-1306	28	8	are	be	AUX
dti-1306	28	9	not	not	PART
dti-1306	28	10	sucessful	sucessful	ADJ
dti-1306	28	11	198	198	NUM
dti-1306	28	12	ningaraj	ningaraj	ADJ
dti-1306	28	13	et	et	PROPN
dti-1306	28	14	al	al	PROPN
dti-1306	28	15	drug	drug	PROPN
dti-1306	28	16	target	target	NOUN
dti-1306	28	17	insights	insight	NOUN
dti-1306	28	18	2007	2007	NUM
dti-1306	28	19	:	:	SYM
dti-1306	28	20	2	2	NUM
dti-1306	28	21	because	because	SCONJ
dti-1306	28	22	the	the	DET
dti-1306	28	23	cancer	cancer	NOUN
dti-1306	28	24	cells	cell	NOUN
dti-1306	28	25	develop	develop	VERB
dti-1306	28	26	resistance	resistance	NOUN
dti-1306	28	27	to	to	ADP
dti-1306	28	28	treatment	treatment	NOUN
dti-1306	28	29	.	.	PUNCT
dti-1306	29	1	anti	anti	ADJ
dti-1306	29	2	-	-	ADJ
dti-1306	29	3	cancer	cancer	ADJ
dti-1306	29	4	drugs	drug	NOUN
dti-1306	29	5	fail	fail	VERB
dti-1306	29	6	to	to	PART
dti-1306	29	7	penetrate	penetrate	VERB
dti-1306	29	8	the	the	DET
dti-1306	29	9	bbb	bbb	NOUN
dti-1306	29	10	in	in	ADP
dti-1306	29	11	suffi	suffi	NOUN
dti-1306	29	12	cient	cient	NOUN
dti-1306	29	13	quantities	quantity	NOUN
dti-1306	29	14	(	(	PUNCT
dti-1306	29	15	pardridge	pardridge	NOUN
dti-1306	29	16	,	,	PUNCT
dti-1306	29	17	2001	2001	NUM
dti-1306	29	18	)	)	PUNCT
dti-1306	29	19	,	,	PUNCT
dti-1306	29	20	allowing	allow	VERB
dti-1306	29	21	cancer	cancer	NOUN
dti-1306	29	22	cells	cell	NOUN
dti-1306	29	23	to	to	PART
dti-1306	29	24	develop	develop	VERB
dti-1306	29	25	resistance	resistance	NOUN
dti-1306	29	26	to	to	ADP
dti-1306	29	27	these	these	DET
dti-1306	29	28	agents	agent	NOUN
dti-1306	29	29	.	.	PUNCT
dti-1306	30	1	therefore	therefore	ADV
dti-1306	30	2	,	,	PUNCT
dti-1306	30	3	understanding	understand	VERB
dti-1306	30	4	the	the	DET
dti-1306	30	5	biochemical	biochemical	ADJ
dti-1306	30	6	regulation	regulation	NOUN
dti-1306	30	7	of	of	ADP
dti-1306	30	8	the	the	DET
dti-1306	30	9	bbb	bbb	PROPN
dti-1306	30	10	(	(	PUNCT
dti-1306	30	11	fig	fig	NOUN
dti-1306	30	12	.	.	NOUN
dti-1306	30	13	1	1	NUM
dti-1306	30	14	)	)	PUNCT
dti-1306	30	15	in	in	ADP
dti-1306	30	16	normal	normal	ADJ
dti-1306	30	17	and	and	CCONJ
dti-1306	30	18	tumor	tumor	NOUN
dti-1306	30	19	-	-	PUNCT
dti-1306	30	20	invaded	invade	VERB
dti-1306	30	21	brain	brain	NOUN
dti-1306	30	22	is	be	AUX
dti-1306	30	23	of	of	ADP
dti-1306	30	24	great	great	ADJ
dti-1306	30	25	importance	importance	NOUN
dti-1306	30	26	to	to	PART
dti-1306	30	27	develop	develop	VERB
dti-1306	30	28	therapeutics	therapeutic	NOUN
dti-1306	30	29	that	that	PRON
dti-1306	30	30	breach	breach	VERB
dti-1306	30	31	or	or	CCONJ
dti-1306	30	32	circumvent	circumvent	VERB
dti-1306	30	33	bbb	bbb	NOUN
dti-1306	30	34	and	and	CCONJ
dti-1306	30	35	directly	directly	ADV
dti-1306	30	36	target	target	VERB
dti-1306	30	37	brain	brain	NOUN
dti-1306	30	38	tumor	tumor	NOUN
dti-1306	30	39	cells	cell	NOUN
dti-1306	30	40	(	(	PUNCT
dti-1306	30	41	ningaraj	ningaraj	ADJ
dti-1306	30	42	,	,	PUNCT
dti-1306	30	43	2006	2006	NUM
dti-1306	30	44	)	)	PUNCT
dti-1306	30	45	.	.	PUNCT
dti-1306	31	1	the	the	DET
dti-1306	31	2	focus	focus	NOUN
dti-1306	31	3	is	be	AUX
dti-1306	31	4	now	now	ADV
dti-1306	31	5	on	on	ADP
dti-1306	31	6	the	the	DET
dti-1306	31	7	targeted	target	VERB
dti-1306	31	8	cancer	cancer	NOUN
dti-1306	31	9	therapies	therapy	NOUN
dti-1306	31	10	(	(	PUNCT
dti-1306	31	11	butowski	butowski	NOUN
dti-1306	31	12	and	and	CCONJ
dti-1306	31	13	chang	chang	PROPN
dti-1306	31	14	,	,	PUNCT
dti-1306	31	15	2005	2005	NUM
dti-1306	31	16	)	)	PUNCT
dti-1306	31	17	that	that	PRON
dti-1306	31	18	complement	complement	VERB
dti-1306	31	19	conventional	conventional	ADJ
dti-1306	31	20	treatments	treatment	NOUN
dti-1306	31	21	and	and	CCONJ
dti-1306	31	22	reduce	reduce	VERB
dti-1306	31	23	the	the	DET
dti-1306	31	24	drug	drug	NOUN
dti-1306	31	25	resistance	resistance	NOUN
dti-1306	31	26	in	in	ADP
dti-1306	31	27	cancer	cancer	NOUN
dti-1306	31	28	cells	cell	NOUN
dti-1306	31	29	and	and	CCONJ
dti-1306	31	30	the	the	DET
dti-1306	31	31	toxicity	toxicity	NOUN
dti-1306	31	32	in	in	ADP
dti-1306	31	33	normal	normal	ADJ
dti-1306	31	34	brain	brain	NOUN
dti-1306	31	35	(	(	PUNCT
dti-1306	31	36	newton	newton	PROPN
dti-1306	31	37	,	,	PUNCT
dti-1306	31	38	2003	2003	NUM
dti-1306	31	39	)	)	PUNCT
dti-1306	31	40	.	.	PUNCT
dti-1306	32	1	novel	novel	ADJ
dti-1306	32	2	cancer	cancer	NOUN
dti-1306	32	3	therapies	therapy	NOUN
dti-1306	32	4	include	include	VERB
dti-1306	32	5	anti	anti	ADJ
dti-1306	32	6	-	-	ADJ
dti-1306	32	7	angiogenic	angiogenic	ADJ
dti-1306	32	8	agents	agent	NOUN
dti-1306	32	9	,	,	PUNCT
dti-1306	32	10	immunotherapy	immunotherapy	NOUN
dti-1306	32	11	,	,	PUNCT
dti-1306	32	12	bacterial	bacterial	ADJ
dti-1306	32	13	agents	agent	NOUN
dti-1306	32	14	,	,	PUNCT
dti-1306	32	15	viral	viral	ADJ
dti-1306	32	16	oncolysis	oncolysis	NOUN
dti-1306	32	17	,	,	PUNCT
dti-1306	32	18	cyclin	cyclin	NOUN
dti-1306	32	19	-	-	PUNCT
dti-1306	32	20	dependent	dependent	ADJ
dti-1306	32	21	kinases	kinase	NOUN
dti-1306	32	22	and	and	CCONJ
dti-1306	32	23	receptor	receptor	NOUN
dti-1306	32	24	tyrosine	tyrosine	PROPN
dti-1306	32	25	kinase	kinase	PROPN
dti-1306	32	26	inhibitors	inhibitor	NOUN
dti-1306	32	27	(	(	PUNCT
dti-1306	32	28	rtkis	rtkis	PROPN
dti-1306	32	29	)	)	PUNCT
dti-1306	32	30	,	,	PUNCT
dti-1306	32	31	anti	anti	ADJ
dti-1306	32	32	-	-	ADJ
dti-1306	32	33	sense	sense	ADJ
dti-1306	32	34	agents	agent	NOUN
dti-1306	32	35	,	,	PUNCT
dti-1306	32	36	gene	gene	NOUN
dti-1306	32	37	therapy	therapy	NOUN
dti-1306	32	38	,	,	PUNCT
dti-1306	32	39	microrna	microrna	PROPN
dti-1306	32	40	(	(	PUNCT
dti-1306	32	41	mirna	mirna	PROPN
dti-1306	32	42	)	)	PUNCT
dti-1306	32	43	,	,	PUNCT
dti-1306	32	44	and	and	CCONJ
dti-1306	32	45	combinations	combination	NOUN
dti-1306	32	46	of	of	ADP
dti-1306	32	47	various	various	ADJ
dti-1306	32	48	methods	method	NOUN
dti-1306	32	49	(	(	PUNCT
dti-1306	32	50	butowski	butowski	NOUN
dti-1306	32	51	and	and	CCONJ
dti-1306	32	52	chang	chang	PROPN
dti-1306	32	53	,	,	PUNCT
dti-1306	32	54	2005	2005	NUM
dti-1306	32	55	)	)	PUNCT
dti-1306	32	56	.	.	PUNCT
dti-1306	33	1	chemotherapy	chemotherapy	NOUN
dti-1306	33	2	chemotherapy	chemotherapy	NOUN
dti-1306	33	3	is	be	AUX
dti-1306	33	4	a	a	DET
dti-1306	33	5	form	form	NOUN
dti-1306	33	6	of	of	ADP
dti-1306	33	7	targeted	target	VERB
dti-1306	33	8	therapy	therapy	NOUN
dti-1306	33	9	where	where	SCONJ
dti-1306	33	10	cytotoxic	cytotoxic	ADJ
dti-1306	33	11	drugs	drug	NOUN
dti-1306	33	12	act	act	VERB
dti-1306	33	13	on	on	ADP
dti-1306	33	14	multiplying	multiply	VERB
dti-1306	33	15	tumor	tumor	NOUN
dti-1306	33	16	cells	cell	NOUN
dti-1306	33	17	.	.	PUNCT
dti-1306	34	1	the	the	DET
dti-1306	34	2	drugs	drug	NOUN
dti-1306	34	3	can	can	AUX
dti-1306	34	4	also	also	ADV
dti-1306	34	5	be	be	AUX
dti-1306	34	6	used	use	VERB
dti-1306	34	7	as	as	ADP
dti-1306	34	8	sensitizers	sensitizer	NOUN
dti-1306	34	9	to	to	PART
dti-1306	34	10	augment	augment	VERB
dti-1306	34	11	the	the	DET
dti-1306	34	12	effects	effect	NOUN
dti-1306	34	13	of	of	ADP
dti-1306	34	14	radiation	radiation	NOUN
dti-1306	34	15	therapy	therapy	NOUN
dti-1306	34	16	.	.	PUNCT
dti-1306	35	1	chemotherapeutic	chemotherapeutic	ADJ
dti-1306	35	2	drugs	drug	NOUN
dti-1306	35	3	can	can	AUX
dti-1306	35	4	be	be	AUX
dti-1306	35	5	delivered	deliver	VERB
dti-1306	35	6	directly	directly	ADV
dti-1306	35	7	to	to	ADP
dti-1306	35	8	brain	brain	NOUN
dti-1306	35	9	tumors	tumor	NOUN
dti-1306	35	10	through	through	ADP
dti-1306	35	11	a	a	DET
dti-1306	35	12	polymer	polymer	NOUN
dti-1306	35	13	wafer	wafer	NOUN
dti-1306	35	14	implant	implant	NOUN
dti-1306	35	15	such	such	ADJ
dti-1306	35	16	as	as	ADP
dti-1306	35	17	a	a	DET
dti-1306	35	18	biodegradable	biodegradable	ADJ
dti-1306	35	19	wafer	wafer	NOUN
dti-1306	35	20	soaked	soak	VERB
dti-1306	35	21	with	with	ADP
dti-1306	35	22	bcnu	bcnu	NOUN
dti-1306	35	23	(	(	PUNCT
dti-1306	35	24	carmustine	carmustine	NOUN
dti-1306	35	25	)	)	PUNCT
dti-1306	35	26	.	.	PUNCT
dti-1306	36	1	besides	besides	SCONJ
dti-1306	36	2	bcnu	bcnu	NOUN
dti-1306	36	3	,	,	PUNCT
dti-1306	36	4	several	several	ADJ
dti-1306	36	5	other	other	ADJ
dti-1306	36	6	chemotherapy	chemotherapy	NOUN
dti-1306	36	7	drugs	drug	NOUN
dti-1306	36	8	are	be	AUX
dti-1306	36	9	used	use	VERB
dti-1306	36	10	to	to	PART
dti-1306	36	11	treat	treat	VERB
dti-1306	36	12	brain	brain	NOUN
dti-1306	36	13	tumors	tumor	NOUN
dti-1306	36	14	,	,	PUNCT
dti-1306	36	15	which	which	PRON
dti-1306	36	16	are	be	AUX
dti-1306	36	17	administered	administer	VERB
dti-1306	36	18	by	by	ADP
dti-1306	36	19	various	various	ADJ
dti-1306	36	20	routes	route	NOUN
dti-1306	36	21	.	.	PUNCT
dti-1306	37	1	the	the	DET
dti-1306	37	2	chemotherapeutic	chemotherapeutic	ADJ
dti-1306	37	3	drugs	drug	NOUN
dti-1306	37	4	taken	take	VERB
dti-1306	37	5	orally	orally	ADV
dti-1306	37	6	include	include	VERB
dti-1306	37	7	temozolomide	temozolomide	NOUN
dti-1306	37	8	(	(	PUNCT
dti-1306	37	9	tmz	tmz	NOUN
dti-1306	37	10	,	,	PUNCT
dti-1306	37	11	temodar	temodar	NOUN
dti-1306	37	12	)	)	PUNCT
dti-1306	37	13	,	,	PUNCT
dti-1306	37	14	procarbazine	procarbazine	NOUN
dti-1306	37	15	(	(	PUNCT
dti-1306	37	16	matulane	matulane	NOUN
dti-1306	37	17	)	)	PUNCT
dti-1306	37	18	,	,	PUNCT
dti-1306	37	19	and	and	CCONJ
dti-1306	37	20	lomustine	lomustine	NOUN
dti-1306	37	21	(	(	PUNCT
dti-1306	37	22	ccnu	ccnu	NOUN
dti-1306	37	23	)	)	PUNCT
dti-1306	37	24	.	.	PUNCT
dti-1306	38	1	the	the	DET
dti-1306	38	2	intravenously	intravenously	ADV
dti-1306	38	3	administered	administer	VERB
dti-1306	38	4	drugs	drug	NOUN
dti-1306	38	5	include	include	VERB
dti-1306	38	6	vincristine	vincristine	NOUN
dti-1306	38	7	(	(	PUNCT
dti-1306	38	8	oncovin	oncovin	PROPN
dti-1306	38	9	or	or	CCONJ
dti-1306	38	10	vincasar	vincasar	ADJ
dti-1306	38	11	pfs	pfs	PROPN
dti-1306	38	12	)	)	PUNCT
dti-1306	38	13	,	,	PUNCT
dti-1306	38	14	cisplatin	cisplatin	NOUN
dti-1306	38	15	(	(	PUNCT
dti-1306	38	16	platinol	platinol	NOUN
dti-1306	38	17	)	)	PUNCT
dti-1306	38	18	,	,	PUNCT
dti-1306	38	19	carmustine	carmustine	NOUN
dti-1306	38	20	(	(	PUNCT
dti-1306	38	21	bcnu	bcnu	NOUN
dti-1306	38	22	,	,	PUNCT
dti-1306	38	23	bicnu	bicnu	NOUN
dti-1306	38	24	)	)	PUNCT
dti-1306	38	25	,	,	PUNCT
dti-1306	38	26	carboplatin	carboplatin	NOUN
dti-1306	38	27	(	(	PUNCT
dti-1306	38	28	paraplatin	paraplatin	NOUN
dti-1306	38	29	)	)	PUNCT
dti-1306	38	30	,	,	PUNCT
dti-1306	38	31	while	while	SCONJ
dti-1306	38	32	methotrexate	methotrexate	X
dti-1306	38	33	(	(	PUNCT
dti-1306	38	34	rheumatrex	rheumatrex	ADJ
dti-1306	38	35	or	or	CCONJ
dti-1306	38	36	trexall	trexall	PROPN
dti-1306	38	37	)	)	PUNCT
dti-1306	38	38	may	may	AUX
dti-1306	38	39	be	be	AUX
dti-1306	38	40	taken	take	VERB
dti-1306	38	41	orally	orally	ADV
dti-1306	38	42	,	,	PUNCT
dti-1306	38	43	by	by	ADP
dti-1306	38	44	injection	injection	NOUN
dti-1306	38	45	,	,	PUNCT
dti-1306	38	46	or	or	CCONJ
dti-1306	38	47	intrathecally	intrathecally	ADV
dti-1306	38	48	.	.	PUNCT
dti-1306	39	1	treating	treat	VERB
dti-1306	39	2	brain	brain	NOUN
dti-1306	39	3	tumors	tumor	NOUN
dti-1306	39	4	with	with	ADP
dti-1306	39	5	chemotherapy	chemotherapy	NOUN
dti-1306	39	6	can	can	AUX
dti-1306	39	7	be	be	AUX
dti-1306	39	8	diffi	diffi	ADJ
dti-1306	39	9	cult	cult	NOUN
dti-1306	39	10	because	because	SCONJ
dti-1306	39	11	the	the	DET
dti-1306	39	12	brain	brain	NOUN
dti-1306	39	13	is	be	AUX
dti-1306	39	14	protected	protect	VERB
dti-1306	39	15	by	by	ADP
dti-1306	39	16	bbb	bbb	PROPN
dti-1306	39	17	,	,	PUNCT
dti-1306	39	18	which	which	PRON
dti-1306	39	19	keeps	keep	VERB
dti-1306	39	20	out	out	ADP
dti-1306	39	21	harmful	harmful	ADJ
dti-1306	39	22	substances	substance	NOUN
dti-1306	39	23	such	such	ADJ
dti-1306	39	24	as	as	ADP
dti-1306	39	25	bacteria	bacteria	NOUN
dti-1306	39	26	and	and	CCONJ
dti-1306	39	27	chemotherapeutic	chemotherapeutic	ADJ
dti-1306	39	28	drugs	drug	NOUN
dti-1306	39	29	.	.	PUNCT
dti-1306	40	1	among	among	ADP
dti-1306	40	2	many	many	ADJ
dti-1306	40	3	cytotoxic	cytotoxic	ADJ
dti-1306	40	4	agents	agent	NOUN
dti-1306	40	5	in	in	ADP
dti-1306	40	6	the	the	DET
dti-1306	40	7	clinician	clinician	NOUN
dti-1306	40	8	’s	’s	PART
dti-1306	40	9	arsenal	arsenal	ADJ
dti-1306	40	10	,	,	PUNCT
dti-1306	40	11	temozolomide	temozolomide	NOUN
dti-1306	40	12	(	(	PUNCT
dti-1306	40	13	tmz	tmz	PROPN
dti-1306	40	14	)	)	PUNCT
dti-1306	40	15	has	have	AUX
dti-1306	40	16	shown	show	VERB
dti-1306	40	17	some	some	DET
dti-1306	40	18	promise	promise	NOUN
dti-1306	40	19	in	in	ADP
dti-1306	40	20	treatment	treatment	NOUN
dti-1306	40	21	of	of	ADP
dti-1306	40	22	low	low	ADJ
dti-1306	40	23	grade	grade	NOUN
dti-1306	40	24	gliomas	glioma	NOUN
dti-1306	40	25	(	(	PUNCT
dti-1306	40	26	friedman	friedman	PROPN
dti-1306	40	27	,	,	PUNCT
dti-1306	40	28	kerby	kerby	PROPN
dti-1306	40	29	and	and	CCONJ
dti-1306	40	30	calvert	calvert	NOUN
dti-1306	40	31	,	,	PUNCT
dti-1306	40	32	2000	2000	NUM
dti-1306	40	33	)	)	PUNCT
dti-1306	40	34	,	,	PUNCT
dti-1306	40	35	however	however	ADV
dti-1306	40	36	,	,	PUNCT
dti-1306	40	37	the	the	DET
dti-1306	40	38	effect	effect	NOUN
dti-1306	40	39	on	on	ADP
dti-1306	40	40	patient	patient	ADJ
dti-1306	40	41	survival	survival	NOUN
dti-1306	40	42	was	be	AUX
dti-1306	40	43	modest	modest	ADJ
dti-1306	40	44	(	(	PUNCT
dti-1306	40	45	balana	balana	NOUN
dti-1306	40	46	et	et	PROPN
dti-1306	40	47	al	al	PROPN
dti-1306	40	48	.	.	PROPN
dti-1306	40	49	2004	2004	NUM
dti-1306	40	50	)	)	PUNCT
dti-1306	40	51	.	.	PUNCT
dti-1306	41	1	the	the	DET
dti-1306	41	2	problem	problem	NOUN
dti-1306	41	3	is	be	AUX
dti-1306	41	4	that	that	SCONJ
dti-1306	41	5	glioblastoma	glioblastoma	NOUN
dti-1306	41	6	multiforme	multiforme	NOUN
dti-1306	41	7	(	(	PUNCT
dti-1306	41	8	gbm	gbm	PROPN
dti-1306	41	9	)	)	PUNCT
dti-1306	41	10	exhibits	exhibit	VERB
dti-1306	41	11	varying	vary	VERB
dti-1306	41	12	responses	response	NOUN
dti-1306	41	13	to	to	ADP
dti-1306	41	14	tmz	tmz	PROPN
dti-1306	41	15	(	(	PUNCT
dti-1306	41	16	hirose	hirose	PROPN
dti-1306	41	17	,	,	PUNCT
dti-1306	41	18	berger	berger	PROPN
dti-1306	41	19	and	and	CCONJ
dti-1306	41	20	pieper	pieper	NOUN
dti-1306	41	21	,	,	PUNCT
dti-1306	41	22	2001	2001	NUM
dti-1306	41	23	)	)	PUNCT
dti-1306	41	24	,	,	PUNCT
dti-1306	41	25	and	and	CCONJ
dti-1306	41	26	in	in	ADP
dti-1306	41	27	some	some	DET
dti-1306	41	28	cases	case	NOUN
dti-1306	41	29	gliomas	glioma	NOUN
dti-1306	41	30	have	have	AUX
dti-1306	41	31	increased	increase	VERB
dti-1306	41	32	o6	o6	NOUN
dti-1306	41	33	-	-	PUNCT
dti-1306	41	34	methyl	methyl	NOUN
dti-1306	41	35	guanine	guanine	NOUN
dti-1306	41	36	methyl	methyl	NOUN
dti-1306	41	37	transferase	transferase	NOUN
dti-1306	41	38	(	(	PUNCT
dti-1306	41	39	mgmt	mgmt	NOUN
dti-1306	41	40	)	)	PUNCT
dti-1306	41	41	activity	activity	NOUN
dti-1306	41	42	,	,	PUNCT
dti-1306	41	43	which	which	PRON
dti-1306	41	44	results	result	VERB
dti-1306	41	45	in	in	ADP
dti-1306	41	46	complete	complete	ADJ
dti-1306	41	47	resistance	resistance	NOUN
dti-1306	41	48	to	to	ADP
dti-1306	41	49	tmz	tmz	PROPN
dti-1306	41	50	(	(	PUNCT
dti-1306	41	51	bocangel	bocangel	NOUN
dti-1306	41	52	et	et	PROPN
dti-1306	41	53	al	al	PROPN
dti-1306	41	54	.	.	PROPN
dti-1306	41	55	2002	2002	NUM
dti-1306	41	56	)	)	PUNCT
dti-1306	41	57	.	.	PUNCT
dti-1306	42	1	the	the	DET
dti-1306	42	2	clinical	clinical	ADJ
dti-1306	42	3	utility	utility	NOUN
dti-1306	42	4	of	of	ADP
dti-1306	42	5	tmz	tmz	NOUN
dti-1306	42	6	against	against	ADP
dti-1306	42	7	all	all	DET
dti-1306	42	8	types	type	NOUN
dti-1306	42	9	of	of	ADP
dti-1306	42	10	brain	brain	NOUN
dti-1306	42	11	tumors	tumor	NOUN
dti-1306	42	12	remains	remain	VERB
dti-1306	42	13	limited	limited	ADJ
dti-1306	42	14	due	due	ADP
dti-1306	42	15	to	to	ADP
dti-1306	42	16	its	its	PRON
dti-1306	42	17	btb	btb	NOUN
dti-1306	42	18	penetration	penetration	NOUN
dti-1306	42	19	(	(	PUNCT
dti-1306	42	20	some	some	DET
dti-1306	42	21	authors	author	NOUN
dti-1306	42	22	claim	claim	VERB
dti-1306	42	23	tmz	tmz	NOUN
dti-1306	42	24	metabolite	metabolite	NOUN
dti-1306	42	25	(	(	PUNCT
dti-1306	42	26	mtic	mtic	ADJ
dti-1306	42	27	)	)	PUNCT
dti-1306	42	28	concentration	concentration	NOUN
dti-1306	42	29	in	in	ADP
dti-1306	42	30	csf	csf	NOUN
dti-1306	42	31	to	to	PART
dti-1306	42	32	be	be	AUX
dti-1306	42	33	as	as	ADV
dti-1306	42	34	high	high	ADJ
dti-1306	42	35	as	as	ADP
dti-1306	42	36	30	30	NUM
dti-1306	42	37	%	%	NOUN
dti-1306	42	38	)	)	PUNCT
dti-1306	42	39	,	,	PUNCT
dti-1306	42	40	which	which	PRON
dti-1306	42	41	demand	demand	NOUN
dti-1306	42	42	repeated	repeat	VERB
dti-1306	42	43	high	high	ADJ
dti-1306	42	44	doses	dose	NOUN
dti-1306	42	45	to	to	PART
dti-1306	42	46	achieve	achieve	VERB
dti-1306	42	47	in	in	ADP
dti-1306	42	48	vivo	vivo	ADJ
dti-1306	42	49	therapeutically	therapeutically	ADV
dti-1306	42	50	effective	effective	ADJ
dti-1306	42	51	concentrations	concentration	NOUN
dti-1306	42	52	in	in	ADP
dti-1306	42	53	brain	brain	NOUN
dti-1306	42	54	tumors	tumor	NOUN
dti-1306	42	55	(	(	PUNCT
dti-1306	42	56	yung	yung	NOUN
dti-1306	42	57	et	et	PROPN
dti-1306	42	58	al	al	PROPN
dti-1306	42	59	.	.	PROPN
dti-1306	42	60	1999	1999	NUM
dti-1306	42	61	)	)	PUNCT
dti-1306	42	62	,	,	PUNCT
dti-1306	42	63	and	and	CCONJ
dti-1306	42	64	different	different	ADJ
dti-1306	42	65	phenotypes	phenotype	NOUN
dti-1306	42	66	and	and	CCONJ
dti-1306	42	67	genotypes	genotype	NOUN
dti-1306	42	68	that	that	PRON
dti-1306	42	69	render	render	VERB
dti-1306	42	70	some	some	DET
dti-1306	42	71	form	form	NOUN
dti-1306	42	72	of	of	ADP
dti-1306	42	73	resistance	resistance	NOUN
dti-1306	42	74	against	against	ADP
dti-1306	42	75	tmz	tmz	PROPN
dti-1306	42	76	(	(	PUNCT
dti-1306	42	77	kanzawa	kanzawa	PROPN
dti-1306	42	78	et	et	PROPN
dti-1306	42	79	al	al	PROPN
dti-1306	42	80	.	.	PROPN
dti-1306	42	81	2003	2003	NUM
dti-1306	42	82	)	)	PUNCT
dti-1306	42	83	.	.	PUNCT
dti-1306	43	1	most	most	ADV
dti-1306	43	2	importantly	importantly	ADV
dti-1306	43	3	,	,	PUNCT
dti-1306	43	4	an	an	DET
dti-1306	43	5	extensive	extensive	ADJ
dti-1306	43	6	literature	literature	NOUN
dti-1306	43	7	search	search	NOUN
dti-1306	43	8	and	and	CCONJ
dti-1306	43	9	preliminary	preliminary	ADJ
dti-1306	43	10	work	work	NOUN
dti-1306	43	11	on	on	ADP
dti-1306	43	12	bbb	bbb	PROPN
dti-1306	43	13	/	/	SYM
dti-1306	43	14	btb	btb	NOUN
dti-1306	43	15	penetration	penetration	NOUN
dti-1306	43	16	of	of	ADP
dti-1306	43	17	tmz	tmz	NOUN
dti-1306	43	18	did	do	AUX
dti-1306	43	19	not	not	PART
dti-1306	43	20	convince	convince	VERB
dti-1306	43	21	us	we	PRON
dti-1306	43	22	that	that	DET
dti-1306	43	23	suffi	suffi	PROPN
dti-1306	43	24	cient	cient	NOUN
dti-1306	43	25	amount	amount	NOUN
dti-1306	43	26	of	of	ADP
dti-1306	43	27	drug	drug	NOUN
dti-1306	43	28	penetrates	penetrate	VERB
dti-1306	43	29	the	the	DET
dti-1306	43	30	bbb	bbb	NOUN
dti-1306	43	31	or	or	CCONJ
dti-1306	43	32	btb	btb	VERB
dti-1306	43	33	to	to	PART
dti-1306	43	34	elicit	elicit	VERB
dti-1306	43	35	anti	anti	ADJ
dti-1306	43	36	-	-	ADJ
dti-1306	43	37	tumor	tumor	ADJ
dti-1306	43	38	effect	effect	NOUN
dti-1306	43	39	.	.	PUNCT
dti-1306	44	1	to	to	PART
dti-1306	44	2	circumvent	circumvent	VERB
dti-1306	44	3	the	the	DET
dti-1306	44	4	penetration	penetration	NOUN
dti-1306	44	5	problem	problem	NOUN
dti-1306	44	6	,	,	PUNCT
dti-1306	44	7	chemotherapy	chemotherapy	NOUN
dti-1306	44	8	drugs	drug	NOUN
dti-1306	44	9	can	can	AUX
dti-1306	44	10	be	be	AUX
dti-1306	44	11	delivered	deliver	VERB
dti-1306	44	12	by	by	ADP
dti-1306	44	13	figure	figure	NOUN
dti-1306	44	14	1	1	NUM
dti-1306	44	15	.	.	PUNCT
dti-1306	45	1	a	a	DET
dti-1306	45	2	schematic	schematic	ADJ
dti-1306	45	3	representation	representation	NOUN
dti-1306	45	4	of	of	ADP
dti-1306	45	5	normal	normal	ADJ
dti-1306	45	6	and	and	CCONJ
dti-1306	45	7	abnormal	abnormal	ADJ
dti-1306	45	8	blood	blood	NOUN
dti-1306	45	9	-	-	PUNCT
dti-1306	45	10	brain	brain	NOUN
dti-1306	45	11	barriers	barrier	NOUN
dti-1306	45	12	.	.	PUNCT
dti-1306	46	1	we	we	PRON
dti-1306	46	2	reason	reason	VERB
dti-1306	46	3	that	that	SCONJ
dti-1306	46	4	genes	gene	NOUN
dti-1306	46	5	in	in	ADP
dti-1306	46	6	brain	brain	NOUN
dti-1306	46	7	cancers	cancer	NOUN
dti-1306	46	8	/	/	SYM
dti-1306	46	9	vasculature	vasculature	NOUN
dti-1306	46	10	are	be	AUX
dti-1306	46	11	distinct	distinct	ADJ
dti-1306	46	12	from	from	ADP
dti-1306	46	13	normal	normal	ADJ
dti-1306	46	14	brain	brain	NOUN
dti-1306	46	15	/	/	SYM
dti-1306	46	16	vasculature	vasculature	NOUN
dti-1306	46	17	.	.	PUNCT
dti-1306	47	1	they	they	PRON
dti-1306	47	2	are	be	AUX
dti-1306	47	3	attractive	attractive	ADJ
dti-1306	47	4	targets	target	NOUN
dti-1306	47	5	for	for	ADP
dti-1306	47	6	the	the	DET
dti-1306	47	7	design	design	NOUN
dti-1306	47	8	of	of	ADP
dti-1306	47	9	therapies	therapy	NOUN
dti-1306	47	10	that	that	PRON
dti-1306	47	11	can	can	AUX
dti-1306	47	12	penetrate	penetrate	VERB
dti-1306	47	13	the	the	DET
dti-1306	47	14	btb	btb	NOUN
dti-1306	47	15	and	and	CCONJ
dti-1306	47	16	selectively	selectively	ADV
dti-1306	47	17	kill	kill	VERB
dti-1306	47	18	brain	brain	NOUN
dti-1306	47	19	cancer	cancer	NOUN
dti-1306	47	20	cells	cell	NOUN
dti-1306	47	21	.	.	PUNCT
dti-1306	48	1	we	we	PRON
dti-1306	48	2	are	be	AUX
dti-1306	48	3	studying	study	VERB
dti-1306	48	4	the	the	DET
dti-1306	48	5	genes	gene	NOUN
dti-1306	48	6	that	that	PRON
dti-1306	48	7	direct	direct	VERB
dti-1306	48	8	the	the	DET
dti-1306	48	9	formation	formation	NOUN
dti-1306	48	10	of	of	ADP
dti-1306	48	11	the	the	DET
dti-1306	48	12	normal	normal	ADJ
dti-1306	48	13	and	and	CCONJ
dti-1306	48	14	abnormal	abnormal	ADJ
dti-1306	48	15	(	(	PUNCT
dti-1306	48	16	cancer	cancer	NOUN
dti-1306	48	17	)	)	PUNCT
dti-1306	48	18	human	human	ADJ
dti-1306	48	19	brain	brain	NOUN
dti-1306	48	20	vasculature	vasculature	NOUN
dti-1306	48	21	,	,	PUNCT
dti-1306	48	22	and	and	CCONJ
dti-1306	48	23	with	with	ADP
dti-1306	48	24	this	this	DET
dti-1306	48	25	knowledge	knowledge	NOUN
dti-1306	48	26	develop	develop	VERB
dti-1306	48	27	new	new	ADJ
dti-1306	48	28	treatment	treatment	NOUN
dti-1306	48	29	strategies	strategy	NOUN
dti-1306	48	30	for	for	ADP
dti-1306	48	31	brain	brain	NOUN
dti-1306	48	32	tumor	tumor	NOUN
dti-1306	48	33	patients	patient	NOUN
dti-1306	48	34	.	.	PUNCT
dti-1306	49	1	ec	ec	NOUN
dti-1306	49	2	:	:	PUNCT
dti-1306	49	3	endothelial	endothelial	ADJ
dti-1306	49	4	cells	cell	NOUN
dti-1306	49	5	;	;	PUNCT
dti-1306	49	6	tj	tj	X
dti-1306	49	7	:	:	PUNCT
dti-1306	49	8	tight	tight	ADJ
dti-1306	49	9	junction	junction	NOUN
dti-1306	49	10	proteins	protein	NOUN
dti-1306	49	11	;	;	PUNCT
dti-1306	49	12	n	n	CCONJ
dti-1306	49	13	:	:	PUNCT
dti-1306	50	1	nucleus	nucleus	NOUN
dti-1306	50	2	.	.	PUNCT
dti-1306	51	1	199	199	NUM
dti-1306	51	2	targeted	target	VERB
dti-1306	51	3	brain	brain	NOUN
dti-1306	51	4	tumor	tumor	NOUN
dti-1306	51	5	treatment	treatment	NOUN
dti-1306	51	6	drug	drug	NOUN
dti-1306	51	7	target	target	NOUN
dti-1306	51	8	insights	insight	NOUN
dti-1306	51	9	2007	2007	NUM
dti-1306	51	10	:	:	PUNCT
dti-1306	51	11	2	2	NUM
dti-1306	51	12	intratumoral	intratumoral	ADJ
dti-1306	51	13	route	route	NOUN
dti-1306	51	14	or	or	CCONJ
dti-1306	51	15	by	by	ADP
dti-1306	51	16	drug	drug	NOUN
dti-1306	51	17	impregnated	impregnate	VERB
dti-1306	51	18	wafers	wafer	NOUN
dti-1306	51	19	to	to	PART
dti-1306	51	20	attain	attain	VERB
dti-1306	51	21	higher	high	ADJ
dti-1306	51	22	concentration	concentration	NOUN
dti-1306	51	23	of	of	ADP
dti-1306	51	24	drugs	drug	NOUN
dti-1306	51	25	in	in	ADP
dti-1306	51	26	the	the	DET
dti-1306	51	27	tumor	tumor	NOUN
dti-1306	51	28	cells	cell	NOUN
dti-1306	51	29	,	,	PUNCT
dti-1306	51	30	but	but	CCONJ
dti-1306	51	31	the	the	DET
dti-1306	51	32	procedures	procedure	NOUN
dti-1306	51	33	are	be	AUX
dti-1306	51	34	highly	highly	ADV
dti-1306	51	35	invasive	invasive	ADJ
dti-1306	51	36	.	.	PUNCT
dti-1306	52	1	targeted	target	VERB
dti-1306	52	2	brain	brain	NOUN
dti-1306	52	3	tumor	tumor	NOUN
dti-1306	52	4	treatment	treatment	NOUN
dti-1306	52	5	the	the	DET
dti-1306	52	6	human	human	ADJ
dti-1306	52	7	genome	genome	NOUN
dti-1306	52	8	project	project	NOUN
dti-1306	52	9	has	have	AUX
dti-1306	52	10	raised	raise	VERB
dti-1306	52	11	the	the	DET
dti-1306	52	12	expectation	expectation	NOUN
dti-1306	52	13	of	of	ADP
dti-1306	52	14	the	the	DET
dti-1306	52	15	development	development	NOUN
dti-1306	52	16	of	of	ADP
dti-1306	52	17	novel	novel	ADJ
dti-1306	52	18	therapies	therapy	NOUN
dti-1306	52	19	for	for	ADP
dti-1306	52	20	brain	brain	NOUN
dti-1306	52	21	tumor	tumor	NOUN
dti-1306	52	22	because	because	SCONJ
dti-1306	52	23	the	the	DET
dti-1306	52	24	conventional	conventional	ADJ
dti-1306	52	25	treatment	treatment	NOUN
dti-1306	52	26	strategies	strategy	NOUN
dti-1306	52	27	have	have	AUX
dti-1306	52	28	not	not	PART
dti-1306	52	29	yielded	yield	VERB
dti-1306	52	30	any	any	DET
dti-1306	52	31	significant	significant	ADJ
dti-1306	52	32	clinical	clinical	ADJ
dti-1306	52	33	outcome	outcome	NOUN
dti-1306	52	34	.	.	PUNCT
dti-1306	53	1	brain	brain	NOUN
dti-1306	53	2	tumor	tumor	PROPN
dti-1306	53	3	treatment	treatment	NOUN
dti-1306	53	4	differs	differ	VERB
dti-1306	53	5	according	accord	VERB
dti-1306	53	6	to	to	ADP
dti-1306	53	7	the	the	DET
dti-1306	53	8	grade	grade	NOUN
dti-1306	53	9	and	and	CCONJ
dti-1306	53	10	location	location	NOUN
dti-1306	53	11	of	of	ADP
dti-1306	53	12	the	the	DET
dti-1306	53	13	tumor	tumor	NOUN
dti-1306	53	14	.	.	PUNCT
dti-1306	54	1	hence	hence	ADV
dti-1306	54	2	,	,	PUNCT
dti-1306	54	3	combination	combination	NOUN
dti-1306	54	4	of	of	ADP
dti-1306	54	5	surgery	surgery	NOUN
dti-1306	54	6	,	,	PUNCT
dti-1306	54	7	chemotherapy	chemotherapy	NOUN
dti-1306	54	8	,	,	PUNCT
dti-1306	54	9	and	and	CCONJ
dti-1306	54	10	radiotherapy	radiotherapy	NOUN
dti-1306	54	11	can	can	AUX
dti-1306	54	12	be	be	AUX
dti-1306	54	13	used	use	VERB
dti-1306	54	14	in	in	ADP
dti-1306	54	15	treating	treat	VERB
dti-1306	54	16	brain	brain	NOUN
dti-1306	54	17	tumor	tumor	NOUN
dti-1306	54	18	patients	patient	NOUN
dti-1306	54	19	(	(	PUNCT
dti-1306	54	20	stupp	stupp	PROPN
dti-1306	54	21	et	et	PROPN
dti-1306	54	22	al	al	PROPN
dti-1306	54	23	.	.	PROPN
dti-1306	54	24	2005	2005	NUM
dti-1306	54	25	)	)	PUNCT
dti-1306	54	26	.	.	PUNCT
dti-1306	55	1	most	most	ADV
dti-1306	55	2	promising	promising	ADJ
dti-1306	55	3	anti	anti	ADJ
dti-1306	55	4	-	-	ADJ
dti-1306	55	5	cancer	cancer	ADJ
dti-1306	55	6	drugs	drug	NOUN
dti-1306	55	7	for	for	ADP
dti-1306	55	8	pediatric	pediatric	ADJ
dti-1306	55	9	and	and	CCONJ
dti-1306	55	10	adult	adult	NOUN
dti-1306	55	11	patients	patient	NOUN
dti-1306	55	12	that	that	PRON
dti-1306	55	13	are	be	AUX
dti-1306	55	14	effective	effective	ADJ
dti-1306	55	15	against	against	ADP
dti-1306	55	16	cancers	cancer	NOUN
dti-1306	55	17	outside	outside	ADP
dti-1306	55	18	the	the	DET
dti-1306	55	19	brain	brain	NOUN
dti-1306	55	20	have	have	AUX
dti-1306	55	21	failed	fail	VERB
dti-1306	55	22	against	against	ADP
dti-1306	55	23	brain	brain	NOUN
dti-1306	55	24	tumors	tumor	NOUN
dti-1306	55	25	in	in	ADP
dti-1306	55	26	clinical	clinical	ADJ
dti-1306	55	27	trails	trail	NOUN
dti-1306	55	28	,	,	PUNCT
dti-1306	55	29	in	in	ADP
dti-1306	55	30	part	part	NOUN
dti-1306	55	31	,	,	PUNCT
dti-1306	55	32	due	due	ADP
dti-1306	55	33	to	to	ADP
dti-1306	55	34	poor	poor	ADJ
dti-1306	55	35	penetration	penetration	NOUN
dti-1306	55	36	across	across	ADP
dti-1306	55	37	the	the	DET
dti-1306	55	38	bbb	bbb	PROPN
dti-1306	55	39	.	.	PUNCT
dti-1306	56	1	for	for	ADP
dti-1306	56	2	instance	instance	NOUN
dti-1306	56	3	,	,	PUNCT
dti-1306	56	4	aberrant	aberrant	ADJ
dti-1306	56	5	expression	expression	NOUN
dti-1306	56	6	of	of	ADP
dti-1306	56	7	src	src	PROPN
dti-1306	56	8	family	family	PROPN
dti-1306	56	9	kinase	kinase	PROPN
dti-1306	56	10	(	(	PUNCT
dti-1306	56	11	lck	lck	PROPN
dti-1306	56	12	)	)	PUNCT
dti-1306	56	13	(	(	PUNCT
dti-1306	56	14	fabian	fabian	PROPN
dti-1306	56	15	et	et	PROPN
dti-1306	56	16	al	al	PROPN
dti-1306	56	17	.	.	PROPN
dti-1306	56	18	2005	2005	NUM
dti-1306	56	19	)	)	PUNCT
dti-1306	56	20	or	or	CCONJ
dti-1306	56	21	mutation	mutation	NOUN
dti-1306	56	22	of	of	ADP
dti-1306	56	23	c	c	NOUN
dti-1306	56	24	-	-	PUNCT
dti-1306	56	25	kit	kit	NOUN
dti-1306	56	26	are	be	AUX
dti-1306	56	27	involved	involve	VERB
dti-1306	56	28	in	in	ADP
dti-1306	56	29	the	the	DET
dti-1306	56	30	pathogenesis	pathogenesis	NOUN
dti-1306	56	31	of	of	ADP
dti-1306	56	32	many	many	ADJ
dti-1306	56	33	cancers	cancer	NOUN
dti-1306	56	34	.	.	PUNCT
dti-1306	57	1	studies	study	NOUN
dti-1306	57	2	using	use	VERB
dti-1306	57	3	imatinib	imatinib	NOUN
dti-1306	57	4	mesylate	mesylate	NOUN
dti-1306	57	5	(	(	PUNCT
dti-1306	57	6	sti	sti	PROPN
dti-1306	57	7	571	571	NUM
dti-1306	57	8	,	,	PUNCT
dti-1306	57	9	gleevec	gleevec	PROPN
dti-1306	57	10	,	,	PUNCT
dti-1306	57	11	novartis	novartis	PROPN
dti-1306	57	12	,	,	PUNCT
dti-1306	57	13	u.s.a	u.s.a	NOUN
dti-1306	57	14	.	.	PUNCT
dti-1306	57	15	)	)	PUNCT
dti-1306	57	16	,	,	PUNCT
dti-1306	57	17	an	an	DET
dti-1306	57	18	inhibitor	inhibitor	NOUN
dti-1306	57	19	of	of	ADP
dti-1306	57	20	the	the	DET
dti-1306	57	21	tyrosine	tyrosine	NOUN
dti-1306	57	22	kinases	kinases	PROPN
dti-1306	57	23	brc	brc	PROPN
dti-1306	57	24	-	-	PUNCT
dti-1306	57	25	abl	abl	PROPN
dti-1306	57	26	,	,	PUNCT
dti-1306	57	27	c	c	NOUN
dti-1306	57	28	-	-	PUNCT
dti-1306	57	29	kit	kit	NOUN
dti-1306	57	30	,	,	PUNCT
dti-1306	57	31	and	and	CCONJ
dti-1306	57	32	pdgfr	pdgfr	ADJ
dti-1306	57	33	,	,	PUNCT
dti-1306	57	34	have	have	AUX
dti-1306	57	35	shown	show	VERB
dti-1306	57	36	signifi	signifi	NOUN
dti-1306	57	37	ca	can	AUX
dti-1306	57	38	nt	not	PART
dti-1306	57	39	response	response	VERB
dti-1306	57	40	in	in	ADP
dti-1306	57	41	patients	patient	NOUN
dti-1306	57	42	with	with	ADP
dti-1306	57	43	chronic	chronic	ADJ
dti-1306	57	44	myelogenous	myelogenous	ADJ
dti-1306	57	45	leukemia	leukemia	NOUN
dti-1306	57	46	(	(	PUNCT
dti-1306	57	47	cml	cml	PROPN
dti-1306	57	48	)	)	PUNCT
dti-1306	57	49	and	and	CCONJ
dti-1306	57	50	gastrointestinal	gastrointestinal	ADJ
dti-1306	57	51	stromal	stromal	ADJ
dti-1306	57	52	tumor	tumor	NOUN
dti-1306	57	53	(	(	PUNCT
dti-1306	57	54	gist	gist	NOUN
dti-1306	57	55	)	)	PUNCT
dti-1306	57	56	.	.	PUNCT
dti-1306	58	1	clinical	clinical	ADJ
dti-1306	58	2	trials	trial	NOUN
dti-1306	58	3	were	be	AUX
dti-1306	58	4	recently	recently	ADV
dti-1306	58	5	conducted	conduct	VERB
dti-1306	58	6	to	to	PART
dti-1306	58	7	test	test	VERB
dti-1306	58	8	the	the	DET
dti-1306	58	9	effi	effi	PROPN
dti-1306	58	10	cacy	cacy	NOUN
dti-1306	58	11	of	of	ADP
dti-1306	58	12	gleevec	gleevec	PROPN
dti-1306	58	13	in	in	ADP
dti-1306	58	14	brain	brain	NOUN
dti-1306	58	15	tumors	tumor	NOUN
dti-1306	58	16	(	(	PUNCT
dti-1306	58	17	reardon	reardon	PROPN
dti-1306	58	18	et	et	PROPN
dti-1306	58	19	al	al	PROPN
dti-1306	58	20	.	.	PROPN
dti-1306	58	21	2005	2005	NUM
dti-1306	58	22	;	;	PUNCT
dti-1306	58	23	wen	wen	PROPN
dti-1306	58	24	et	et	PROPN
dti-1306	58	25	al	al	PROPN
dti-1306	58	26	.	.	PROPN
dti-1306	58	27	2006	2006	NUM
dti-1306	58	28	;	;	PUNCT
dti-1306	58	29	pollack	pollack	PROPN
dti-1306	58	30	et	et	PROPN
dti-1306	58	31	al	al	PROPN
dti-1306	58	32	.	.	PROPN
dti-1306	58	33	2007	2007	NUM
dti-1306	58	34	)	)	PUNCT
dti-1306	58	35	.	.	PUNCT
dti-1306	59	1	gleevec	gleevec	PROPN
dti-1306	59	2	is	be	AUX
dti-1306	59	3	an	an	DET
dti-1306	59	4	effective	effective	ADJ
dti-1306	59	5	agent	agent	NOUN
dti-1306	59	6	that	that	PRON
dti-1306	59	7	targets	target	VERB
dti-1306	59	8	specifi	specifi	PROPN
dti-1306	59	9	c	c	PROPN
dti-1306	59	10	gene	gene	NOUN
dti-1306	59	11	/	/	SYM
dti-1306	59	12	protein	protein	NOUN
dti-1306	59	13	in	in	ADP
dti-1306	59	14	cancer	cancer	NOUN
dti-1306	59	15	cells	cell	NOUN
dti-1306	59	16	without	without	ADP
dti-1306	59	17	harming	harm	VERB
dti-1306	59	18	normal	normal	ADJ
dti-1306	59	19	cells	cell	NOUN
dti-1306	59	20	and	and	CCONJ
dti-1306	59	21	tissues	tissue	NOUN
dti-1306	59	22	.	.	PUNCT
dti-1306	60	1	drugs	drug	NOUN
dti-1306	60	2	like	like	ADP
dti-1306	60	3	gleevec	gleevec	NOUN
dti-1306	60	4	and	and	CCONJ
dti-1306	60	5	temozolomide	temozolomide	NOUN
dti-1306	60	6	attack	attack	NOUN
dti-1306	60	7	abnormal	abnormal	ADJ
dti-1306	60	8	chemical	chemical	NOUN
dti-1306	60	9	signals	signal	NOUN
dti-1306	60	10	or	or	CCONJ
dti-1306	60	11	molecules	molecule	NOUN
dti-1306	60	12	inside	inside	ADP
dti-1306	60	13	the	the	DET
dti-1306	60	14	cells	cell	NOUN
dti-1306	60	15	or	or	CCONJ
dti-1306	60	16	on	on	ADP
dti-1306	60	17	the	the	DET
dti-1306	60	18	surface	surface	NOUN
dti-1306	60	19	of	of	ADP
dti-1306	60	20	the	the	DET
dti-1306	60	21	cells	cell	NOUN
dti-1306	60	22	that	that	PRON
dti-1306	60	23	have	have	AUX
dti-1306	60	24	enabled	enable	VERB
dti-1306	60	25	brain	brain	NOUN
dti-1306	60	26	tumor	tumor	NOUN
dti-1306	60	27	cells	cell	NOUN
dti-1306	60	28	to	to	PART
dti-1306	60	29	escape	escape	VERB
dti-1306	60	30	the	the	DET
dti-1306	60	31	normal	normal	ADJ
dti-1306	60	32	growth	growth	NOUN
dti-1306	60	33	controls	control	NOUN
dti-1306	60	34	.	.	PUNCT
dti-1306	61	1	therefore	therefore	ADV
dti-1306	61	2	,	,	PUNCT
dti-1306	61	3	combating	combat	VERB
dti-1306	61	4	many	many	ADJ
dti-1306	61	5	forms	form	NOUN
dti-1306	61	6	of	of	ADP
dti-1306	61	7	cancer	cancer	NOUN
dti-1306	61	8	will	will	AUX
dti-1306	61	9	probably	probably	ADV
dti-1306	61	10	require	require	VERB
dti-1306	61	11	a	a	DET
dti-1306	61	12	variety	variety	NOUN
dti-1306	61	13	of	of	ADP
dti-1306	61	14	targeted	target	VERB
dti-1306	61	15	drugs	drug	NOUN
dti-1306	61	16	used	use	VERB
dti-1306	61	17	in	in	ADP
dti-1306	61	18	combination	combination	NOUN
dti-1306	61	19	,	,	PUNCT
dti-1306	61	20	as	as	SCONJ
dti-1306	61	21	cancer	cancer	NOUN
dti-1306	61	22	involves	involve	VERB
dti-1306	61	23	different	different	ADJ
dti-1306	61	24	types	type	NOUN
dti-1306	61	25	of	of	ADP
dti-1306	61	26	dysfunctional	dysfunctional	ADJ
dti-1306	61	27	genes	gene	NOUN
dti-1306	61	28	and	and	CCONJ
dti-1306	61	29	no	no	DET
dti-1306	61	30	single	single	ADJ
dti-1306	61	31	or	or	CCONJ
dti-1306	61	32	two	two	NUM
dti-1306	61	33	drugs	drug	NOUN
dti-1306	61	34	will	will	AUX
dti-1306	61	35	be	be	AUX
dti-1306	61	36	sufficient	sufficient	ADJ
dti-1306	61	37	.	.	PUNCT
dti-1306	62	1	some	some	DET
dti-1306	62	2	cancers	cancer	NOUN
dti-1306	62	3	,	,	PUNCT
dti-1306	62	4	particularly	particularly	ADV
dti-1306	62	5	primary	primary	ADJ
dti-1306	62	6	and	and	CCONJ
dti-1306	62	7	metastatic	metastatic	ADJ
dti-1306	62	8	brain	brain	NOUN
dti-1306	62	9	tumors	tumor	NOUN
dti-1306	62	10	of	of	ADP
dti-1306	62	11	the	the	DET
dti-1306	62	12	breast	breast	NOUN
dti-1306	62	13	and	and	CCONJ
dti-1306	62	14	lung	lung	NOUN
dti-1306	62	15	are	be	AUX
dti-1306	62	16	diffi	diffi	ADJ
dti-1306	62	17	cult	cult	NOUN
dti-1306	62	18	to	to	PART
dti-1306	62	19	treat	treat	VERB
dti-1306	62	20	because	because	SCONJ
dti-1306	62	21	they	they	PRON
dti-1306	62	22	are	be	AUX
dti-1306	62	23	caused	cause	VERB
dti-1306	62	24	by	by	ADP
dti-1306	62	25	multiple	multiple	ADJ
dti-1306	62	26	signaling	signal	VERB
dti-1306	62	27	pathways	pathway	NOUN
dti-1306	62	28	that	that	PRON
dti-1306	62	29	are	be	AUX
dti-1306	62	30	running	run	VERB
dti-1306	62	31	amok	amok	ADV
dti-1306	62	32	,	,	PUNCT
dti-1306	62	33	rather	rather	ADV
dti-1306	62	34	than	than	ADP
dti-1306	62	35	just	just	ADV
dti-1306	62	36	one	one	NUM
dti-1306	62	37	,	,	PUNCT
dti-1306	62	38	as	as	SCONJ
dti-1306	62	39	observed	observe	VERB
dti-1306	62	40	in	in	ADP
dti-1306	62	41	cml	cml	PROPN
dti-1306	62	42	and	and	CCONJ
dti-1306	62	43	gist	gist	NOUN
dti-1306	62	44	(	(	PUNCT
dti-1306	62	45	butowski	butowski	NOUN
dti-1306	62	46	and	and	CCONJ
dti-1306	62	47	chang	chang	PROPN
dti-1306	62	48	,	,	PUNCT
dti-1306	62	49	2005	2005	NUM
dti-1306	62	50	)	)	PUNCT
dti-1306	62	51	.	.	PUNCT
dti-1306	63	1	gleevec	gleevec	PROPN
dti-1306	63	2	may	may	AUX
dti-1306	63	3	potentially	potentially	ADV
dti-1306	63	4	target	target	VERB
dti-1306	63	5	the	the	DET
dti-1306	63	6	above	above	ADV
dti-1306	63	7	mentioned	mention	VERB
dti-1306	63	8	oncogenes	oncogene	NOUN
dti-1306	63	9	in	in	ADP
dti-1306	63	10	brain	brain	NOUN
dti-1306	63	11	tumor	tumor	NOUN
dti-1306	63	12	(	(	PUNCT
dti-1306	63	13	holdhoff	holdhoff	NOUN
dti-1306	63	14	et	et	PROPN
dti-1306	63	15	al	al	PROPN
dti-1306	63	16	.	.	PROPN
dti-1306	63	17	2005	2005	NUM
dti-1306	63	18	)	)	PUNCT
dti-1306	63	19	provided	provide	VERB
dti-1306	63	20	it	it	PRON
dti-1306	63	21	penetrates	penetrate	VERB
dti-1306	63	22	the	the	DET
dti-1306	63	23	bbb	bbb	NOUN
dti-1306	63	24	(	(	PUNCT
dti-1306	63	25	leis	leis	NOUN
dti-1306	63	26	et	et	PROPN
dti-1306	63	27	al	al	PROPN
dti-1306	63	28	.	.	PROPN
dti-1306	63	29	2004	2004	NUM
dti-1306	63	30	)	)	PUNCT
dti-1306	63	31	.	.	PUNCT
dti-1306	64	1	careful	careful	ADJ
dti-1306	64	2	molecular	molecular	ADJ
dti-1306	64	3	studies	study	NOUN
dti-1306	64	4	would	would	AUX
dti-1306	64	5	identify	identify	VERB
dti-1306	64	6	the	the	DET
dti-1306	64	7	stem	stem	NOUN
dti-1306	64	8	cell	cell	NOUN
dti-1306	64	9	factor	factor	NOUN
dti-1306	64	10	/	/	SYM
dti-1306	64	11	c	c	NOUN
dti-1306	64	12	-	-	PUNCT
dti-1306	64	13	kit	kit	NOUN
dti-1306	64	14	pathways	pathway	NOUN
dti-1306	64	15	in	in	ADP
dti-1306	64	16	pediatric	pediatric	ADJ
dti-1306	64	17	brain	brain	NOUN
dti-1306	64	18	tumors	tumor	NOUN
dti-1306	64	19	,	,	PUNCT
dti-1306	64	20	which	which	PRON
dti-1306	64	21	might	might	AUX
dti-1306	64	22	be	be	AUX
dti-1306	64	23	the	the	DET
dti-1306	64	24	target	target	NOUN
dti-1306	64	25	of	of	ADP
dti-1306	64	26	gleevec	gleevec	PROPN
dti-1306	64	27	.	.	PUNCT
dti-1306	65	1	characterizing	characterize	VERB
dti-1306	65	2	the	the	DET
dti-1306	65	3	genetic	genetic	ADJ
dti-1306	65	4	and	and	CCONJ
dti-1306	65	5	proteomic	proteomic	ADJ
dti-1306	65	6	events	event	NOUN
dti-1306	65	7	that	that	PRON
dti-1306	65	8	play	play	VERB
dti-1306	65	9	a	a	DET
dti-1306	65	10	role	role	NOUN
dti-1306	65	11	in	in	ADP
dti-1306	65	12	the	the	DET
dti-1306	65	13	biology	biology	NOUN
dti-1306	65	14	of	of	ADP
dti-1306	65	15	these	these	DET
dti-1306	65	16	tumors	tumor	NOUN
dti-1306	65	17	may	may	AUX
dti-1306	65	18	allow	allow	VERB
dti-1306	65	19	molecular	molecular	ADJ
dti-1306	65	20	sub	sub	ADJ
dti-1306	65	21	-	-	ADJ
dti-1306	65	22	typing	typing	NOUN
dti-1306	65	23	which	which	PRON
dti-1306	65	24	could	could	AUX
dti-1306	65	25	lead	lead	VERB
dti-1306	65	26	to	to	ADP
dti-1306	65	27	the	the	DET
dti-1306	65	28	development	development	NOUN
dti-1306	65	29	of	of	ADP
dti-1306	65	30	novel	novel	ADJ
dti-1306	65	31	therapeutic	therapeutic	ADJ
dti-1306	65	32	strategies	strategy	NOUN
dti-1306	65	33	,	,	PUNCT
dti-1306	65	34	including	include	VERB
dti-1306	65	35	treatment	treatment	NOUN
dti-1306	65	36	with	with	ADP
dti-1306	65	37	gleevec	gleevec	PROPN
dti-1306	65	38	or	or	CCONJ
dti-1306	65	39	with	with	ADP
dti-1306	65	40	potassium	potassium	NOUN
dti-1306	65	41	channel	channel	NOUN
dti-1306	65	42	modulators	modulator	NOUN
dti-1306	65	43	targeting	target	VERB
dti-1306	65	44	tumor	tumor	NOUN
dti-1306	65	45	and	and	CCONJ
dti-1306	65	46	tumor	tumor	NOUN
dti-1306	65	47	blood	blood	NOUN
dti-1306	65	48	vessel	vessel	NOUN
dti-1306	65	49	endothelial	endothelial	NOUN
dti-1306	65	50	cells	cell	NOUN
dti-1306	65	51	(	(	PUNCT
dti-1306	65	52	ningaraj	ningaraj	ADJ
dti-1306	65	53	,	,	PUNCT
dti-1306	65	54	2006	2006	NUM
dti-1306	65	55	)	)	PUNCT
dti-1306	65	56	.	.	PUNCT
dti-1306	66	1	targeting	target	VERB
dti-1306	66	2	brain	brain	NOUN
dti-1306	66	3	tumors	tumor	NOUN
dti-1306	66	4	targeting	target	VERB
dti-1306	66	5	tumor	tumor	NOUN
dti-1306	66	6	and	and	CCONJ
dti-1306	66	7	tumor	tumor	NOUN
dti-1306	66	8	blood	blood	NOUN
dti-1306	66	9	vessel	vessel	NOUN
dti-1306	66	10	-	-	PUNCT
dti-1306	66	11	specific	specific	ADJ
dti-1306	66	12	marker(s	marker(s	NOUN
dti-1306	66	13	)	)	PUNCT
dti-1306	66	14	is	be	AUX
dti-1306	66	15	a	a	DET
dti-1306	66	16	good	good	ADJ
dti-1306	66	17	strategy	strategy	NOUN
dti-1306	66	18	to	to	PART
dti-1306	66	19	control	control	VERB
dti-1306	66	20	tumor	tumor	NOUN
dti-1306	66	21	growth	growth	NOUN
dti-1306	66	22	(	(	PUNCT
dti-1306	66	23	robinson	robinson	PROPN
dti-1306	66	24	et	et	PROPN
dti-1306	66	25	al	al	PROPN
dti-1306	66	26	.	.	PROPN
dti-1306	66	27	2003	2003	NUM
dti-1306	66	28	)	)	PUNCT
dti-1306	66	29	.	.	PUNCT
dti-1306	67	1	it	it	PRON
dti-1306	67	2	is	be	AUX
dti-1306	67	3	,	,	PUNCT
dti-1306	67	4	however	however	ADV
dti-1306	67	5	,	,	PUNCT
dti-1306	67	6	critical	critical	ADJ
dti-1306	67	7	to	to	PART
dti-1306	67	8	study	study	VERB
dti-1306	67	9	whether	whether	SCONJ
dti-1306	67	10	tumor	tumor	NOUN
dti-1306	67	11	-	-	PUNCT
dti-1306	67	12	specific	specific	ADJ
dti-1306	67	13	drug	drug	NOUN
dti-1306	67	14	delivery	delivery	NOUN
dti-1306	67	15	has	have	VERB
dti-1306	67	16	the	the	DET
dti-1306	67	17	potential	potential	NOUN
dti-1306	67	18	to	to	PART
dti-1306	67	19	minimize	minimize	VERB
dti-1306	67	20	toxicity	toxicity	NOUN
dti-1306	67	21	to	to	ADP
dti-1306	67	22	normal	normal	ADJ
dti-1306	67	23	tissues	tissue	NOUN
dti-1306	67	24	,	,	PUNCT
dti-1306	67	25	and	and	CCONJ
dti-1306	67	26	to	to	PART
dti-1306	67	27	improve	improve	VERB
dti-1306	67	28	the	the	DET
dti-1306	67	29	bioavailability	bioavailability	NOUN
dti-1306	67	30	of	of	ADP
dti-1306	67	31	cytotoxic	cytotoxic	ADJ
dti-1306	67	32	agents	agent	NOUN
dti-1306	67	33	to	to	ADP
dti-1306	67	34	neoplasms	neoplasm	NOUN
dti-1306	67	35	.	.	PUNCT
dti-1306	68	1	existing	exist	VERB
dti-1306	68	2	site	site	NOUN
dti-1306	68	3	-	-	PUNCT
dti-1306	68	4	specific	specific	ADJ
dti-1306	68	5	drug	drug	NOUN
dti-1306	68	6	delivery	delivery	NOUN
dti-1306	68	7	systems	system	NOUN
dti-1306	68	8	include	include	VERB
dti-1306	68	9	delivery	delivery	NOUN
dti-1306	68	10	to	to	ADP
dti-1306	68	11	endothelial	endothelial	ADJ
dti-1306	68	12	receptor	receptor	NOUN
dti-1306	68	13	αvβ3	αvβ3	NOUN
dti-1306	68	14	,	,	PUNCT
dti-1306	68	15	and	and	CCONJ
dti-1306	68	16	tumor	tumor	NOUN
dti-1306	68	17	specific	specific	ADJ
dti-1306	68	18	antigens	antigen	NOUN
dti-1306	68	19	.	.	PUNCT
dti-1306	69	1	antibody	antibody	NOUN
dti-1306	69	2	conjugation	conjugation	NOUN
dti-1306	69	3	to	to	ADP
dti-1306	69	4	cytotoxic	cytotoxic	ADJ
dti-1306	69	5	agents	agent	NOUN
dti-1306	69	6	has	have	AUX
dti-1306	69	7	shown	show	VERB
dti-1306	69	8	promise	promise	NOUN
dti-1306	69	9	in	in	ADP
dti-1306	69	10	achieving	achieve	VERB
dti-1306	69	11	the	the	DET
dti-1306	69	12	goal	goal	NOUN
dti-1306	69	13	of	of	ADP
dti-1306	69	14	tumor	tumor	NOUN
dti-1306	69	15	-	-	PUNCT
dti-1306	69	16	targeted	target	VERB
dti-1306	69	17	cytotoxicity	cytotoxicity	NOUN
dti-1306	69	18	.	.	PUNCT
dti-1306	70	1	this	this	DET
dti-1306	70	2	approach	approach	NOUN
dti-1306	70	3	may	may	AUX
dti-1306	70	4	be	be	AUX
dti-1306	70	5	limited	limit	VERB
dti-1306	70	6	by	by	ADP
dti-1306	70	7	the	the	DET
dti-1306	70	8	small	small	ADJ
dti-1306	70	9	subsets	subset	NOUN
dti-1306	70	10	of	of	ADP
dti-1306	70	11	tumors	tumor	NOUN
dti-1306	70	12	that	that	PRON
dti-1306	70	13	can	can	AUX
dti-1306	70	14	be	be	AUX
dti-1306	70	15	targeted	target	VERB
dti-1306	70	16	by	by	ADP
dti-1306	70	17	these	these	DET
dti-1306	70	18	antibodies	antibody	NOUN
dti-1306	70	19	and	and	CCONJ
dti-1306	70	20	by	by	ADP
dti-1306	70	21	poor	poor	ADJ
dti-1306	70	22	biodistribution	biodistribution	NOUN
dti-1306	70	23	of	of	ADP
dti-1306	70	24	these	these	DET
dti-1306	70	25	antibodies	antibody	NOUN
dti-1306	70	26	into	into	ADP
dti-1306	70	27	solid	solid	ADJ
dti-1306	70	28	tumors	tumor	NOUN
dti-1306	70	29	.	.	PUNCT
dti-1306	71	1	alternative	alternative	ADJ
dti-1306	71	2	approaches	approach	NOUN
dti-1306	71	3	to	to	PART
dti-1306	71	4	target	target	VERB
dti-1306	71	5	all	all	DET
dti-1306	71	6	neoplasms	neoplasm	NOUN
dti-1306	71	7	exploit	exploit	VERB
dti-1306	71	8	differences	difference	NOUN
dti-1306	71	9	in	in	ADP
dti-1306	71	10	human	human	ADJ
dti-1306	71	11	tumor	tumor	NOUN
dti-1306	71	12	blood	blood	NOUN
dti-1306	71	13	vessel	vessel	NOUN
dti-1306	71	14	characteristics	characteristic	NOUN
dti-1306	71	15	when	when	SCONJ
dti-1306	71	16	compared	compare	VERB
dti-1306	71	17	to	to	ADP
dti-1306	71	18	normal	normal	ADJ
dti-1306	71	19	brain	brain	NOUN
dti-1306	71	20	blood	blood	NOUN
dti-1306	71	21	vessels	vessel	NOUN
dti-1306	71	22	(	(	PUNCT
dti-1306	71	23	black	black	ADJ
dti-1306	71	24	and	and	CCONJ
dti-1306	71	25	ningaraj	ningaraj	ADJ
dti-1306	71	26	,	,	PUNCT
dti-1306	71	27	2004	2004	NUM
dti-1306	71	28	;	;	PUNCT
dti-1306	71	29	ningaraj	ningaraj	PROPN
dti-1306	71	30	et	et	PROPN
dti-1306	71	31	al	al	PROPN
dti-1306	71	32	.	.	PROPN
dti-1306	71	33	2002	2002	NUM
dti-1306	71	34	;	;	PUNCT
dti-1306	71	35	ningaraj	ningaraj	ADJ
dti-1306	71	36	,	,	PUNCT
dti-1306	71	37	rao	rao	NOUN
dti-1306	71	38	and	and	CCONJ
dti-1306	71	39	black	black	ADJ
dti-1306	71	40	,	,	PUNCT
dti-1306	71	41	2003a	2003a	NUM
dti-1306	71	42	)	)	PUNCT
dti-1306	71	43	.	.	PUNCT
dti-1306	72	1	epidermal	epidermal	ADJ
dti-1306	72	2	growth	growth	NOUN
dti-1306	72	3	factor	factor	NOUN
dti-1306	72	4	receptor	receptor	NOUN
dti-1306	72	5	(	(	PUNCT
dti-1306	72	6	egfr	egfr	X
dti-1306	72	7	)	)	PUNCT
dti-1306	72	8	is	be	AUX
dti-1306	72	9	often	often	ADV
dti-1306	72	10	amplified	amplify	VERB
dti-1306	72	11	and	and	CCONJ
dti-1306	72	12	mutated	mutate	VERB
dti-1306	72	13	in	in	ADP
dti-1306	72	14	human	human	ADJ
dti-1306	72	15	gliomas	glioma	NOUN
dti-1306	72	16	,	,	PUNCT
dti-1306	72	17	but	but	CCONJ
dti-1306	72	18	the	the	DET
dti-1306	72	19	expression	expression	NOUN
dti-1306	72	20	is	be	AUX
dti-1306	72	21	low	low	ADJ
dti-1306	72	22	or	or	CCONJ
dti-1306	72	23	undetectable	undetectable	ADJ
dti-1306	72	24	in	in	ADP
dti-1306	72	25	normal	normal	ADJ
dti-1306	72	26	brain	brain	NOUN
dti-1306	72	27	.	.	PUNCT
dti-1306	73	1	recently	recently	ADV
dti-1306	73	2	,	,	PUNCT
dti-1306	73	3	egfr	egfr	PROPN
dti-1306	73	4	’s	’s	PART
dti-1306	73	5	mutant	mutant	ADJ
dti-1306	73	6	isoform	isoform	NOUN
dti-1306	73	7	,	,	PUNCT
dti-1306	73	8	variant	variant	NOUN
dti-1306	73	9	iii	iii	NOUN
dti-1306	73	10	of	of	ADP
dti-1306	73	11	the	the	DET
dti-1306	73	12	human	human	ADJ
dti-1306	73	13	egfr	egfr	NOUN
dti-1306	73	14	(	(	PUNCT
dti-1306	73	15	egfrviii	egfrviii	PROPN
dti-1306	73	16	)	)	PUNCT
dti-1306	73	17	,	,	PUNCT
dti-1306	73	18	is	be	AUX
dti-1306	73	19	under	under	ADP
dti-1306	73	20	intensive	intensive	ADJ
dti-1306	73	21	investigation	investigation	NOUN
dti-1306	73	22	as	as	ADP
dti-1306	73	23	potential	potential	ADJ
dti-1306	73	24	molecular	molecular	ADJ
dti-1306	73	25	target	target	NOUN
dti-1306	73	26	for	for	ADP
dti-1306	73	27	the	the	DET
dti-1306	73	28	specific	specific	ADJ
dti-1306	73	29	delivery	delivery	NOUN
dti-1306	73	30	of	of	ADP
dti-1306	73	31	the	the	DET
dti-1306	73	32	diagnostic	diagnostic	ADJ
dti-1306	73	33	and	and	CCONJ
dti-1306	73	34	the	the	DET
dti-1306	73	35	therapeutic	therapeutic	ADJ
dti-1306	73	36	agents	agent	NOUN
dti-1306	73	37	to	to	PART
dti-1306	73	38	brain	brain	NOUN
dti-1306	73	39	tumors	tumor	NOUN
dti-1306	73	40	(	(	PUNCT
dti-1306	73	41	yang	yang	PROPN
dti-1306	73	42	et	et	PROPN
dti-1306	73	43	al	al	PROPN
dti-1306	73	44	.	.	PROPN
dti-1306	73	45	2005	2005	NUM
dti-1306	73	46	)	)	PUNCT
dti-1306	73	47	.	.	PUNCT
dti-1306	74	1	the	the	DET
dti-1306	74	2	therapeutic	therapeutic	ADJ
dti-1306	74	3	monoclonal	monoclonal	NOUN
dti-1306	74	4	antibodies	antibody	NOUN
dti-1306	74	5	(	(	PUNCT
dti-1306	74	6	mab	mab	NOUN
dti-1306	74	7	)	)	PUNCT
dti-1306	74	8	targeting	target	VERB
dti-1306	74	9	growth	growth	NOUN
dti-1306	74	10	factor	factor	NOUN
dti-1306	74	11	pathways	pathway	NOUN
dti-1306	74	12	are	be	AUX
dti-1306	74	13	being	be	AUX
dti-1306	74	14	developed	develop	VERB
dti-1306	74	15	.	.	PUNCT
dti-1306	75	1	the	the	DET
dti-1306	75	2	purpose	purpose	NOUN
dti-1306	75	3	of	of	ADP
dti-1306	75	4	antibody	antibody	NOUN
dti-1306	75	5	treatment	treatment	NOUN
dti-1306	75	6	of	of	ADP
dti-1306	75	7	cancer	cancer	NOUN
dti-1306	75	8	is	be	AUX
dti-1306	75	9	to	to	PART
dti-1306	75	10	induce	induce	VERB
dti-1306	75	11	the	the	DET
dti-1306	75	12	direct	direct	ADJ
dti-1306	75	13	or	or	CCONJ
dti-1306	75	14	indirect	indirect	ADJ
dti-1306	75	15	destruction	destruction	NOUN
dti-1306	75	16	of	of	ADP
dti-1306	75	17	cancer	cancer	NOUN
dti-1306	75	18	cells	cell	NOUN
dti-1306	75	19	,	,	PUNCT
dti-1306	75	20	either	either	CCONJ
dti-1306	75	21	by	by	ADP
dti-1306	75	22	specifically	specifically	ADV
dti-1306	75	23	targeting	target	VERB
dti-1306	75	24	the	the	DET
dti-1306	75	25	tumor	tumor	NOUN
dti-1306	75	26	or	or	CCONJ
dti-1306	75	27	the	the	DET
dti-1306	75	28	tumor	tumor	NOUN
dti-1306	75	29	vasculature	vasculature	NOUN
dti-1306	75	30	(	(	PUNCT
dti-1306	75	31	butowski	butowski	NOUN
dti-1306	75	32	and	and	CCONJ
dti-1306	75	33	chang	chang	PROPN
dti-1306	75	34	,	,	PUNCT
dti-1306	75	35	2005	2005	NUM
dti-1306	75	36	)	)	PUNCT
dti-1306	75	37	.	.	PUNCT
dti-1306	76	1	examples	example	NOUN
dti-1306	76	2	of	of	ADP
dti-1306	76	3	therapeutic	therapeutic	ADJ
dti-1306	76	4	antibodies	antibody	NOUN
dti-1306	76	5	which	which	PRON
dti-1306	76	6	are	be	AUX
dti-1306	76	7	effective	effective	ADJ
dti-1306	76	8	in	in	ADP
dti-1306	76	9	treating	treat	VERB
dti-1306	76	10	cancer	cancer	NOUN
dti-1306	76	11	includes	include	VERB
dti-1306	76	12	the	the	DET
dti-1306	76	13	humanized	humanize	VERB
dti-1306	76	14	igg	igg	PROPN
dti-1306	76	15	antibody	antibody	NOUN
dti-1306	76	16	herceptin	herceptin	NOUN
dti-1306	76	17	for	for	ADP
dti-1306	76	18	the	the	DET
dti-1306	76	19	treatment	treatment	NOUN
dti-1306	76	20	of	of	ADP
dti-1306	76	21	breast	breast	NOUN
dti-1306	76	22	cancer	cancer	NOUN
dti-1306	76	23	,	,	PUNCT
dti-1306	76	24	cetuximab	cetuximab	NOUN
dti-1306	76	25	,	,	PUNCT
dti-1306	76	26	abx	abx	NOUN
dti-1306	76	27	-	-	PUNCT
dti-1306	76	28	egf	egf	PROPN
dti-1306	76	29	,	,	PUNCT
dti-1306	76	30	emd	emd	PROPN
dti-1306	76	31	720000	720000	NUM
dti-1306	76	32	and	and	CCONJ
dti-1306	76	33	h	h	NOUN
dti-1306	76	34	-	-	PUNCT
dti-1306	76	35	r3	r3	NOUN
dti-1306	76	36	directed	direct	VERB
dti-1306	76	37	at	at	ADP
dti-1306	76	38	extracellular	extracellular	ADJ
dti-1306	76	39	receptor	receptor	NOUN
dti-1306	76	40	domain	domain	NOUN
dti-1306	76	41	that	that	PRON
dti-1306	76	42	inhibits	inhibit	VERB
dti-1306	76	43	the	the	DET
dti-1306	76	44	ligand	ligand	ADJ
dti-1306	76	45	-	-	PUNCT
dti-1306	76	46	receptor	receptor	NOUN
dti-1306	76	47	interactions	interaction	NOUN
dti-1306	76	48	.	.	PUNCT
dti-1306	77	1	other	other	ADJ
dti-1306	77	2	antibodies	antibodie	VERB
dti-1306	77	3	200	200	NUM
dti-1306	77	4	ningaraj	ningaraj	ADJ
dti-1306	77	5	et	et	PROPN
dti-1306	77	6	al	al	PROPN
dti-1306	77	7	drug	drug	PROPN
dti-1306	77	8	target	target	NOUN
dti-1306	77	9	insights	insight	NOUN
dti-1306	77	10	2007	2007	NUM
dti-1306	77	11	:	:	SYM
dti-1306	77	12	2	2	NUM
dti-1306	77	13	like	like	ADP
dti-1306	77	14	y10	y10	NOUN
dti-1306	77	15	and	and	CCONJ
dti-1306	77	16	mab806	mab806	PROPN
dti-1306	77	17	,	,	PUNCT
dti-1306	77	18	which	which	PRON
dti-1306	77	19	are	be	AUX
dti-1306	77	20	directed	direct	VERB
dti-1306	77	21	towards	towards	ADP
dti-1306	77	22	the	the	DET
dti-1306	77	23	extracellular	extracellular	ADJ
dti-1306	77	24	portion	portion	NOUN
dti-1306	77	25	of	of	ADP
dti-1306	77	26	egfrviii	egfrviii	NOUN
dti-1306	77	27	in	in	ADP
dti-1306	77	28	gliomas	glioma	NOUN
dti-1306	77	29	have	have	AUX
dti-1306	77	30	also	also	ADV
dti-1306	77	31	shown	show	VERB
dti-1306	77	32	some	some	DET
dti-1306	77	33	activity	activity	NOUN
dti-1306	77	34	in	in	ADP
dti-1306	77	35	clinical	clinical	ADJ
dti-1306	77	36	trials	trial	NOUN
dti-1306	77	37	(	(	PUNCT
dti-1306	77	38	rich	rich	ADJ
dti-1306	77	39	and	and	CCONJ
dti-1306	77	40	bigner	bigner	NOUN
dti-1306	77	41	,	,	PUNCT
dti-1306	77	42	2004	2004	NUM
dti-1306	77	43	)	)	PUNCT
dti-1306	77	44	.	.	PUNCT
dti-1306	78	1	suramin	suramin	NOUN
dti-1306	78	2	(	(	PUNCT
dti-1306	78	3	polysulfonated	polysulfonate	VERB
dti-1306	78	4	napthylurea	napthylurea	NOUN
dti-1306	78	5	)	)	PUNCT
dti-1306	78	6	,	,	PUNCT
dti-1306	78	7	which	which	PRON
dti-1306	78	8	acts	act	VERB
dti-1306	78	9	by	by	ADP
dti-1306	78	10	interfering	interfere	VERB
dti-1306	78	11	with	with	ADP
dti-1306	78	12	the	the	DET
dti-1306	78	13	binding	binding	NOUN
dti-1306	78	14	of	of	ADP
dti-1306	78	15	several	several	ADJ
dti-1306	78	16	growth	growth	NOUN
dti-1306	78	17	factors	factor	NOUN
dti-1306	78	18	-	-	PUNCT
dti-1306	78	19	including	include	VERB
dti-1306	78	20	egf	egf	NOUN
dti-1306	78	21	,	,	PUNCT
dti-1306	78	22	platelet	platelet	NOUN
dti-1306	78	23	derived	derived	ADJ
dti-1306	78	24	growth	growth	NOUN
dti-1306	78	25	factor	factor	NOUN
dti-1306	78	26	(	(	PUNCT
dti-1306	78	27	pdgf	pdgf	NOUN
dti-1306	78	28	)	)	PUNCT
dti-1306	78	29	,	,	PUNCT
dti-1306	78	30	and	and	CCONJ
dti-1306	78	31	insulin	insulin	NOUN
dti-1306	78	32	growth	growth	NOUN
dti-1306	78	33	factor	factor	NOUN
dti-1306	78	34	(	(	PUNCT
dti-1306	78	35	igf1	igf1	PROPN
dti-1306	78	36	)	)	PUNCT
dti-1306	78	37	with	with	ADP
dti-1306	78	38	their	their	PRON
dti-1306	78	39	putative	putative	ADJ
dti-1306	78	40	receptors	receptor	NOUN
dti-1306	78	41	,	,	PUNCT
dti-1306	78	42	is	be	AUX
dti-1306	78	43	being	be	AUX
dti-1306	78	44	tested	test	VERB
dti-1306	78	45	in	in	ADP
dti-1306	78	46	clinical	clinical	ADJ
dti-1306	78	47	trails	trail	NOUN
dti-1306	78	48	.	.	PUNCT
dti-1306	79	1	these	these	DET
dti-1306	79	2	mabs	mab	NOUN
dti-1306	79	3	,	,	PUNCT
dti-1306	79	4	however	however	ADV
dti-1306	79	5	,	,	PUNCT
dti-1306	79	6	have	have	VERB
dti-1306	79	7	poor	poor	ADJ
dti-1306	79	8	penetration	penetration	NOUN
dti-1306	79	9	into	into	ADP
dti-1306	79	10	brain	brain	NOUN
dti-1306	79	11	tumors	tumor	NOUN
dti-1306	79	12	,	,	PUNCT
dti-1306	79	13	which	which	PRON
dti-1306	79	14	results	result	VERB
dti-1306	79	15	in	in	ADP
dti-1306	79	16	recurrence	recurrence	NOUN
dti-1306	79	17	in	in	ADP
dti-1306	79	18	brain	brain	NOUN
dti-1306	79	19	tumor	tumor	NOUN
dti-1306	79	20	patients	patient	NOUN
dti-1306	79	21	.	.	PUNCT
dti-1306	80	1	kinase	kinase	PROPN
dti-1306	80	2	inhibitors	inhibitor	NOUN
dti-1306	80	3	kinase	kinase	VERB
dti-1306	80	4	inhibitors	inhibitor	NOUN
dti-1306	80	5	show	show	VERB
dti-1306	80	6	great	great	ADJ
dti-1306	80	7	promise	promise	NOUN
dti-1306	80	8	as	as	ADP
dti-1306	80	9	a	a	DET
dti-1306	80	10	new	new	ADJ
dti-1306	80	11	class	class	NOUN
dti-1306	80	12	of	of	ADP
dti-1306	80	13	therapeutics	therapeutic	NOUN
dti-1306	80	14	to	to	PART
dti-1306	80	15	control	control	VERB
dti-1306	80	16	gliomas	glioma	NOUN
dti-1306	80	17	.	.	PUNCT
dti-1306	81	1	the	the	DET
dti-1306	81	2	specifi	specifi	PROPN
dti-1306	81	3	city	city	PROPN
dti-1306	81	4	of	of	ADP
dti-1306	81	5	rtkis	rtki	NOUN
dti-1306	81	6	,	,	PUNCT
dti-1306	81	7	including	include	VERB
dti-1306	81	8	those	those	PRON
dti-1306	81	9	that	that	PRON
dti-1306	81	10	are	be	AUX
dti-1306	81	11	in	in	ADP
dti-1306	81	12	clinical	clinical	ADJ
dti-1306	81	13	use	use	NOUN
dti-1306	81	14	or	or	CCONJ
dti-1306	81	15	in	in	ADP
dti-1306	81	16	development	development	NOUN
dti-1306	81	17	widely	widely	ADV
dti-1306	81	18	varies	vary	VERB
dti-1306	81	19	,	,	PUNCT
dti-1306	81	20	and	and	CCONJ
dti-1306	81	21	is	be	AUX
dti-1306	81	22	not	not	PART
dti-1306	81	23	strongly	strongly	ADV
dti-1306	81	24	correlated	correlate	VERB
dti-1306	81	25	with	with	ADP
dti-1306	81	26	chemical	chemical	ADJ
dti-1306	81	27	structure	structure	NOUN
dti-1306	81	28	of	of	ADP
dti-1306	81	29	the	the	DET
dti-1306	81	30	identity	identity	NOUN
dti-1306	81	31	of	of	ADP
dti-1306	81	32	the	the	DET
dti-1306	81	33	intended	intend	VERB
dti-1306	81	34	target	target	NOUN
dti-1306	81	35	.	.	PUNCT
dti-1306	82	1	many	many	ADJ
dti-1306	82	2	novel	novel	ADJ
dti-1306	82	3	interactions	interaction	NOUN
dti-1306	82	4	were	be	AUX
dti-1306	82	5	recently	recently	ADV
dti-1306	82	6	identifi	identifi	ADJ
dti-1306	82	7	ed	ed	PROPN
dti-1306	82	8	(	(	PUNCT
dti-1306	82	9	fabian	fabian	PROPN
dti-1306	82	10	et	et	PROPN
dti-1306	82	11	al	al	PROPN
dti-1306	82	12	.	.	PROPN
dti-1306	82	13	2005	2005	NUM
dti-1306	82	14	)	)	PUNCT
dti-1306	82	15	.	.	PUNCT
dti-1306	83	1	egfr	egfr	PROPN
dti-1306	83	2	and	and	CCONJ
dti-1306	83	3	pdgfr	pdgfr	ADJ
dti-1306	83	4	are	be	AUX
dti-1306	83	5	abnormal	abnormal	ADJ
dti-1306	83	6	genes	gene	NOUN
dti-1306	83	7	identifi	identifi	VERB
dti-1306	83	8	ed	ed	NOUN
dti-1306	83	9	in	in	ADP
dti-1306	83	10	gliomas	glioma	NOUN
dti-1306	83	11	(	(	PUNCT
dti-1306	83	12	rich	rich	ADJ
dti-1306	83	13	and	and	CCONJ
dti-1306	83	14	bigner	bigner	NOUN
dti-1306	83	15	,	,	PUNCT
dti-1306	83	16	2004	2004	NUM
dti-1306	83	17	)	)	PUNCT
dti-1306	83	18	,	,	PUNCT
dti-1306	83	19	whose	whose	DET
dti-1306	83	20	expression	expression	NOUN
dti-1306	83	21	is	be	AUX
dti-1306	83	22	linked	link	VERB
dti-1306	83	23	to	to	ADP
dti-1306	83	24	an	an	DET
dti-1306	83	25	increased	increase	VERB
dti-1306	83	26	rate	rate	NOUN
dti-1306	83	27	of	of	ADP
dti-1306	83	28	tumor	tumor	NOUN
dti-1306	83	29	cell	cell	NOUN
dti-1306	83	30	proliferation	proliferation	NOUN
dti-1306	83	31	,	,	PUNCT
dti-1306	83	32	resistance	resistance	NOUN
dti-1306	83	33	to	to	ADP
dti-1306	83	34	chemotherapy	chemotherapy	NOUN
dti-1306	83	35	,	,	PUNCT
dti-1306	83	36	invasion	invasion	NOUN
dti-1306	83	37	,	,	PUNCT
dti-1306	83	38	and	and	CCONJ
dti-1306	83	39	apoptosis	apoptosis	NOUN
dti-1306	83	40	,	,	PUNCT
dti-1306	83	41	and	and	CCONJ
dti-1306	83	42	hence	hence	ADV
dti-1306	83	43	decreased	decrease	VERB
dti-1306	83	44	survival	survival	NOUN
dti-1306	83	45	in	in	ADP
dti-1306	83	46	patients	patient	NOUN
dti-1306	83	47	with	with	ADP
dti-1306	83	48	malignant	malignant	ADJ
dti-1306	83	49	gliomas	glioma	NOUN
dti-1306	83	50	.	.	PUNCT
dti-1306	84	1	pdgf	pdgf	NOUN
dti-1306	84	2	ligands	ligand	NOUN
dti-1306	84	3	bind	bind	VERB
dti-1306	84	4	to	to	PART
dti-1306	84	5	pdgfrs	pdgfrs	VERB
dti-1306	84	6	to	to	PART
dti-1306	84	7	induce	induce	VERB
dti-1306	84	8	phosphorylation	phosphorylation	NOUN
dti-1306	84	9	and	and	CCONJ
dti-1306	84	10	activation	activation	NOUN
dti-1306	84	11	of	of	ADP
dti-1306	84	12	downstream	downstream	ADJ
dti-1306	84	13	signaling	signal	VERB
dti-1306	84	14	pathways	pathway	NOUN
dti-1306	84	15	such	such	ADJ
dti-1306	84	16	as	as	ADP
dti-1306	84	17	ras	ras	NOUN
dti-1306	84	18	,	,	PUNCT
dti-1306	84	19	mapk	mapk	NOUN
dti-1306	84	20	,	,	PUNCT
dti-1306	84	21	and	and	CCONJ
dti-1306	84	22	akt	akt	PROPN
dti-1306	84	23	.	.	PUNCT
dti-1306	85	1	therefore	therefore	ADV
dti-1306	85	2	,	,	PUNCT
dti-1306	85	3	therapies	therapy	NOUN
dti-1306	85	4	using	use	VERB
dti-1306	85	5	gleevec	gleevec	PROPN
dti-1306	85	6	,	,	PUNCT
dti-1306	85	7	suramin	suramin	NOUN
dti-1306	85	8	,	,	PUNCT
dti-1306	85	9	and	and	CCONJ
dti-1306	85	10	mabs	mab	NOUN
dti-1306	85	11	are	be	AUX
dti-1306	85	12	directed	direct	VERB
dti-1306	85	13	at	at	ADP
dti-1306	85	14	pdgfr	pdgfr	ADJ
dti-1306	85	15	to	to	PART
dti-1306	85	16	control	control	VERB
dti-1306	85	17	glioma	glioma	NOUN
dti-1306	85	18	growth	growth	NOUN
dti-1306	85	19	.	.	PUNCT
dti-1306	86	1	pdgfr	pdgfr	ADJ
dti-1306	86	2	inhibitors	inhibitor	NOUN
dti-1306	86	3	may	may	AUX
dti-1306	86	4	also	also	ADV
dti-1306	86	5	provide	provide	VERB
dti-1306	86	6	additional	additional	ADJ
dti-1306	86	7	benefit	benefit	NOUN
dti-1306	86	8	by	by	ADP
dti-1306	86	9	blocking	block	VERB
dti-1306	86	10	pericytes	pericyte	NOUN
dti-1306	86	11	-	-	PUNCT
dti-1306	86	12	assisted	assist	VERB
dti-1306	86	13	angiogenesis	angiogenesis	NOUN
dti-1306	86	14	(	(	PUNCT
dti-1306	86	15	bergers	berger	NOUN
dti-1306	86	16	et	et	PROPN
dti-1306	86	17	al	al	PROPN
dti-1306	86	18	.	.	PROPN
dti-1306	86	19	2003	2003	NUM
dti-1306	86	20	)	)	PUNCT
dti-1306	86	21	.	.	PUNCT
dti-1306	87	1	clinical	clinical	ADJ
dti-1306	87	2	trials	trial	NOUN
dti-1306	87	3	with	with	ADP
dti-1306	87	4	egfr	egfr	NOUN
dti-1306	87	5	and	and	CCONJ
dti-1306	87	6	pdgfr	pdgfr	ADJ
dti-1306	87	7	inhibitors	inhibitor	NOUN
dti-1306	87	8	have	have	AUX
dti-1306	87	9	shown	show	VERB
dti-1306	87	10	promise	promise	NOUN
dti-1306	87	11	for	for	ADP
dti-1306	87	12	glioma	glioma	NOUN
dti-1306	87	13	therapy	therapy	NOUN
dti-1306	87	14	,	,	PUNCT
dti-1306	87	15	although	although	SCONJ
dti-1306	87	16	their	their	PRON
dti-1306	87	17	ability	ability	NOUN
dti-1306	87	18	to	to	PART
dti-1306	87	19	penetrate	penetrate	VERB
dti-1306	87	20	bbb	bbb	PROPN
dti-1306	87	21	in	in	ADP
dti-1306	87	22	suffi	suffi	PROPN
dti-1306	87	23	cient	cient	NOUN
dti-1306	87	24	amounts	amount	NOUN
dti-1306	87	25	is	be	AUX
dti-1306	87	26	largely	largely	ADV
dti-1306	87	27	unknown	unknown	ADJ
dti-1306	87	28	.	.	PUNCT
dti-1306	88	1	we	we	PRON
dti-1306	88	2	transiently	transiently	ADV
dti-1306	88	3	opened	open	VERB
dti-1306	88	4	the	the	DET
dti-1306	88	5	btb	btb	NOUN
dti-1306	88	6	with	with	ADP
dti-1306	88	7	kca	kca	PROPN
dti-1306	88	8	and	and	CCONJ
dti-1306	88	9	atp	atp	PROPN
dti-1306	88	10	-	-	PUNCT
dti-1306	88	11	sensitive	sensitive	ADJ
dti-1306	88	12	potassium	potassium	NOUN
dti-1306	88	13	(	(	PUNCT
dti-1306	88	14	katp	katp	NOUN
dti-1306	88	15	)	)	PUNCT
dti-1306	88	16	channel	channel	NOUN
dti-1306	88	17	agonists	agonist	NOUN
dti-1306	88	18	(	(	PUNCT
dti-1306	88	19	black	black	ADJ
dti-1306	88	20	and	and	CCONJ
dti-1306	88	21	ningaraj	ningaraj	ADJ
dti-1306	88	22	,	,	PUNCT
dti-1306	88	23	2004	2004	NUM
dti-1306	88	24	;	;	PUNCT
dti-1306	88	25	ningaraj	ningaraj	PROPN
dti-1306	88	26	et	et	PROPN
dti-1306	88	27	al	al	PROPN
dti-1306	88	28	.	.	PROPN
dti-1306	88	29	2002	2002	NUM
dti-1306	88	30	;	;	PUNCT
dti-1306	88	31	ningaraj	ningaraj	ADJ
dti-1306	88	32	,	,	PUNCT
dti-1306	88	33	rao	rao	NOUN
dti-1306	88	34	and	and	CCONJ
dti-1306	88	35	black	black	ADJ
dti-1306	88	36	,	,	PUNCT
dti-1306	88	37	2003a	2003a	NUM
dti-1306	88	38	,	,	PUNCT
dti-1306	88	39	b	b	NOUN
dti-1306	88	40	;	;	PUNCT
dti-1306	88	41	rao	rao	NOUN
dti-1306	88	42	and	and	CCONJ
dti-1306	88	43	ningaraj	ningaraj	ADJ
dti-1306	88	44	,	,	PUNCT
dti-1306	88	45	2001	2001	NUM
dti-1306	88	46	)	)	PUNCT
dti-1306	88	47	to	to	PART
dti-1306	88	48	increase	increase	VERB
dti-1306	88	49	the	the	DET
dti-1306	88	50	delivery	delivery	NOUN
dti-1306	88	51	of	of	ADP
dti-1306	88	52	gleevec	gleevec	PROPN
dti-1306	88	53	and	and	CCONJ
dti-1306	88	54	herceptin	herceptin	PROPN
dti-1306	88	55	to	to	ADP
dti-1306	88	56	human	human	ADJ
dti-1306	88	57	glioma	glioma	NOUN
dti-1306	88	58	xenografts	xenograft	NOUN
dti-1306	88	59	grown	grow	VERB
dti-1306	88	60	in	in	ADP
dti-1306	88	61	murine	murine	ADJ
dti-1306	88	62	brains	brain	NOUN
dti-1306	88	63	.	.	PUNCT
dti-1306	89	1	kca	kca	PROPN
dti-1306	89	2	channels	channel	NOUN
dti-1306	89	3	in	in	ADP
dti-1306	89	4	gliomas	glioma	NOUN
dti-1306	89	5	membrane	membrane	NOUN
dti-1306	89	6	ion	ion	NOUN
dti-1306	89	7	channels	channel	NOUN
dti-1306	89	8	are	be	AUX
dti-1306	89	9	essential	essential	ADJ
dti-1306	89	10	for	for	ADP
dti-1306	89	11	cell	cell	NOUN
dti-1306	89	12	proliferation	proliferation	NOUN
dti-1306	89	13	and	and	CCONJ
dti-1306	89	14	appears	appear	VERB
dti-1306	89	15	to	to	PART
dti-1306	89	16	play	play	VERB
dti-1306	89	17	a	a	DET
dti-1306	89	18	role	role	NOUN
dti-1306	89	19	in	in	ADP
dti-1306	89	20	the	the	DET
dti-1306	89	21	development	development	NOUN
dti-1306	89	22	of	of	ADP
dti-1306	89	23	cancer	cancer	NOUN
dti-1306	89	24	(	(	PUNCT
dti-1306	89	25	ningaraj	ningaraj	ADJ
dti-1306	89	26	,	,	PUNCT
dti-1306	89	27	2006	2006	NUM
dti-1306	89	28	)	)	PUNCT
dti-1306	89	29	.	.	PUNCT
dti-1306	90	1	the	the	DET
dti-1306	90	2	kca	kca	PROPN
dti-1306	90	3	channels	channel	NOUN
dti-1306	90	4	are	be	AUX
dti-1306	90	5	highly	highly	ADV
dti-1306	90	6	expressed	express	VERB
dti-1306	90	7	in	in	ADP
dti-1306	90	8	gliomas	glioma	NOUN
dti-1306	90	9	(	(	PUNCT
dti-1306	90	10	weaver	weaver	NOUN
dti-1306	90	11	,	,	PUNCT
dti-1306	90	12	liu	liu	PROPN
dti-1306	90	13	and	and	CCONJ
dti-1306	90	14	sontheimer	sontheimer	PROPN
dti-1306	90	15	,	,	PUNCT
dti-1306	90	16	2004	2004	NUM
dti-1306	90	17	)	)	PUNCT
dti-1306	90	18	supporting	support	VERB
dti-1306	90	19	the	the	DET
dti-1306	90	20	hypothesis	hypothesis	NOUN
dti-1306	90	21	that	that	PRON
dti-1306	90	22	these	these	DET
dti-1306	90	23	channels	channel	NOUN
dti-1306	90	24	play	play	VERB
dti-1306	90	25	an	an	DET
dti-1306	90	26	important	important	ADJ
dti-1306	90	27	role	role	NOUN
dti-1306	90	28	in	in	ADP
dti-1306	90	29	brain	brain	NOUN
dti-1306	90	30	tumor	tumor	NOUN
dti-1306	90	31	growth	growth	NOUN
dti-1306	90	32	and	and	CCONJ
dti-1306	90	33	possibly	possibly	ADV
dti-1306	90	34	the	the	DET
dti-1306	90	35	progression	progression	NOUN
dti-1306	90	36	of	of	ADP
dti-1306	90	37	low	low	ADJ
dti-1306	90	38	grade	grade	NOUN
dti-1306	90	39	anaplastic	anaplastic	ADJ
dti-1306	90	40	astrocytomas	astrocytoma	NOUN
dti-1306	90	41	(	(	PUNCT
dti-1306	90	42	grade	grade	PROPN
dti-1306	90	43	ii	ii	PROPN
dti-1306	90	44	)	)	PUNCT
dti-1306	90	45	to	to	ADP
dti-1306	90	46	a	a	DET
dti-1306	90	47	deadly	deadly	ADJ
dti-1306	90	48	high	high	ADJ
dti-1306	90	49	grade	grade	NOUN
dti-1306	90	50	gbm	gbm	NOUN
dti-1306	90	51	(	(	PUNCT
dti-1306	90	52	who	who	PRON
dti-1306	90	53	grade	grade	NOUN
dti-1306	90	54	iv	iv	NUM
dti-1306	90	55	)	)	PUNCT
dti-1306	90	56	.	.	PUNCT
dti-1306	91	1	in	in	ADP
dti-1306	91	2	addition	addition	NOUN
dti-1306	91	3	,	,	PUNCT
dti-1306	91	4	studies	study	NOUN
dti-1306	91	5	have	have	AUX
dti-1306	91	6	shown	show	VERB
dti-1306	91	7	that	that	DET
dti-1306	91	8	modulation	modulation	NOUN
dti-1306	91	9	of	of	ADP
dti-1306	91	10	the	the	DET
dti-1306	91	11	biological	biological	ADJ
dti-1306	91	12	function	function	NOUN
dti-1306	91	13	of	of	ADP
dti-1306	91	14	kca	kca	PROPN
dti-1306	91	15	channels	channel	NOUN
dti-1306	91	16	with	with	ADP
dti-1306	91	17	specific	specific	ADJ
dti-1306	91	18	inhibitors	inhibitor	NOUN
dti-1306	91	19	attenuate	attenuate	VERB
dti-1306	91	20	glioma	glioma	NOUN
dti-1306	91	21	growth	growth	NOUN
dti-1306	91	22	(	(	PUNCT
dti-1306	91	23	rao	rao	NOUN
dti-1306	91	24	and	and	CCONJ
dti-1306	91	25	ningaraj	ningaraj	ADJ
dti-1306	91	26	,	,	PUNCT
dti-1306	91	27	2001	2001	NUM
dti-1306	91	28	)	)	PUNCT
dti-1306	91	29	.	.	PUNCT
dti-1306	92	1	another	another	DET
dti-1306	92	2	study	study	NOUN
dti-1306	92	3	showed	show	VERB
dti-1306	92	4	that	that	SCONJ
dti-1306	92	5	the	the	DET
dti-1306	92	6	activation	activation	NOUN
dti-1306	92	7	of	of	ADP
dti-1306	92	8	intermediate	intermediate	ADJ
dti-1306	92	9	kca	kca	PROPN
dti-1306	92	10	channels	channel	NOUN
dti-1306	92	11	with	with	ADP
dti-1306	92	12	its	its	PRON
dti-1306	92	13	opener	opener	NOUN
dti-1306	92	14	caused	cause	VERB
dti-1306	92	15	down	down	ADP
dti-1306	92	16	-	-	PUNCT
dti-1306	92	17	regulation	regulation	NOUN
dti-1306	92	18	of	of	ADP
dti-1306	92	19	these	these	DET
dti-1306	92	20	channels	channel	NOUN
dti-1306	92	21	and	and	CCONJ
dti-1306	92	22	attenuated	attenuate	VERB
dti-1306	92	23	the	the	DET
dti-1306	92	24	non	non	ADJ
dti-1306	92	25	-	-	ADJ
dti-1306	92	26	excitable	excitable	ADJ
dti-1306	92	27	cell	cell	NOUN
dti-1306	92	28	growth	growth	NOUN
dti-1306	92	29	and	and	CCONJ
dti-1306	92	30	its	its	PRON
dti-1306	92	31	proliferation	proliferation	NOUN
dti-1306	92	32	(	(	PUNCT
dti-1306	92	33	kraft	kraft	NOUN
dti-1306	92	34	et	et	PROPN
dti-1306	92	35	al	al	PROPN
dti-1306	92	36	.	.	PROPN
dti-1306	92	37	2003	2003	NUM
dti-1306	92	38	)	)	PUNCT
dti-1306	92	39	.	.	PUNCT
dti-1306	93	1	we	we	PRON
dti-1306	93	2	showed	show	VERB
dti-1306	93	3	that	that	SCONJ
dti-1306	93	4	chronic	chronic	ADJ
dti-1306	93	5	activation	activation	NOUN
dti-1306	93	6	of	of	ADP
dti-1306	93	7	kca	kca	PROPN
dti-1306	93	8	channels	channel	NOUN
dti-1306	93	9	with	with	ADP
dti-1306	93	10	its	its	PRON
dti-1306	93	11	specific	specific	ADJ
dti-1306	93	12	openers	opener	NOUN
dti-1306	93	13	ns-1619	ns-1619	NOUN
dti-1306	93	14	and	and	CCONJ
dti-1306	93	15	ns-004	ns-004	PROPN
dti-1306	93	16	elicited	elicit	VERB
dti-1306	93	17	apoptosis	apoptosis	NOUN
dti-1306	93	18	in	in	ADP
dti-1306	93	19	vitro	vitro	X
dti-1306	93	20	and	and	CCONJ
dti-1306	93	21	in	in	ADP
dti-1306	93	22	vivo	vivo	NOUN
dti-1306	93	23	(	(	PUNCT
dti-1306	93	24	rao	rao	NOUN
dti-1306	93	25	and	and	CCONJ
dti-1306	93	26	ningaraj	ningaraj	ADJ
dti-1306	93	27	,	,	PUNCT
dti-1306	93	28	2001	2001	NUM
dti-1306	93	29	)	)	PUNCT
dti-1306	93	30	.	.	PUNCT
dti-1306	94	1	however	however	ADV
dti-1306	94	2	,	,	PUNCT
dti-1306	94	3	the	the	DET
dti-1306	94	4	role	role	NOUN
dti-1306	94	5	of	of	ADP
dti-1306	94	6	kca	kca	PROPN
dti-1306	94	7	channels	channel	NOUN
dti-1306	94	8	in	in	ADP
dti-1306	94	9	progression	progression	NOUN
dti-1306	94	10	from	from	ADP
dti-1306	94	11	a	a	DET
dti-1306	94	12	treatable	treatable	ADJ
dti-1306	94	13	low	low	ADJ
dti-1306	94	14	grade	grade	NOUN
dti-1306	94	15	to	to	ADP
dti-1306	94	16	an	an	DET
dti-1306	94	17	untreatable	untreatable	ADJ
dti-1306	94	18	high	high	ADJ
dti-1306	94	19	grade	grade	NOUN
dti-1306	94	20	glioma	glioma	NOUN
dti-1306	94	21	in	in	ADP
dti-1306	94	22	pediatric	pediatric	NOUN
dti-1306	94	23	as	as	ADV
dti-1306	94	24	well	well	ADV
dti-1306	94	25	as	as	ADP
dti-1306	94	26	in	in	ADP
dti-1306	94	27	adult	adult	NOUN
dti-1306	94	28	patients	patient	NOUN
dti-1306	94	29	is	be	AUX
dti-1306	94	30	not	not	PART
dti-1306	94	31	fully	fully	ADV
dti-1306	94	32	understood	understand	VERB
dti-1306	94	33	.	.	PUNCT
dti-1306	95	1	recently	recently	ADV
dti-1306	95	2	,	,	PUNCT
dti-1306	95	3	glioma	glioma	NOUN
dti-1306	95	4	kca	kca	PROPN
dti-1306	95	5	/	/	SYM
dti-1306	95	6	bk	bk	PROPN
dti-1306	95	7	channels	channel	NOUN
dti-1306	95	8	(	(	PUNCT
dti-1306	95	9	gbk	gbk	NOUN
dti-1306	95	10	)	)	PUNCT
dti-1306	95	11	splice	splice	NOUN
dti-1306	95	12	variant	variant	NOUN
dti-1306	95	13	of	of	ADP
dti-1306	95	14	the	the	DET
dti-1306	95	15	kcnma1	kcnma1	NOUN
dti-1306	95	16	gene	gene	NOUN
dti-1306	95	17	was	be	AUX
dti-1306	95	18	characterized	characterize	VERB
dti-1306	95	19	by	by	ADP
dti-1306	95	20	enhanced	enhance	VERB
dti-1306	95	21	sensitivity	sensitivity	NOUN
dti-1306	95	22	to	to	ADP
dti-1306	95	23	intracellular	intracellular	ADJ
dti-1306	95	24	calcium	calcium	NOUN
dti-1306	95	25	levels	level	NOUN
dti-1306	95	26	(	(	PUNCT
dti-1306	95	27	weaver	weaver	NOUN
dti-1306	95	28	,	,	PUNCT
dti-1306	95	29	bomben	bomben	NOUN
dti-1306	95	30	and	and	CCONJ
dti-1306	95	31	sontheimer	sontheimer	NOUN
dti-1306	95	32	,	,	PUNCT
dti-1306	95	33	2006	2006	NUM
dti-1306	95	34	)	)	PUNCT
dti-1306	95	35	.	.	PUNCT
dti-1306	96	1	the	the	DET
dti-1306	96	2	study	study	NOUN
dti-1306	96	3	also	also	ADV
dti-1306	96	4	showed	show	VERB
dti-1306	96	5	that	that	SCONJ
dti-1306	96	6	the	the	DET
dti-1306	96	7	expression	expression	NOUN
dti-1306	96	8	of	of	ADP
dti-1306	96	9	functional	functional	ADJ
dti-1306	96	10	gbk	gbk	NOUN
dti-1306	96	11	channels	channel	NOUN
dti-1306	96	12	appears	appear	VERB
dti-1306	96	13	to	to	PART
dti-1306	96	14	be	be	AUX
dti-1306	96	15	regulated	regulate	VERB
dti-1306	96	16	in	in	ADP
dti-1306	96	17	a	a	DET
dti-1306	96	18	growth	growth	NOUN
dti-1306	96	19	-	-	PUNCT
dti-1306	96	20	factor	factor	NOUN
dti-1306	96	21	-	-	PUNCT
dti-1306	96	22	dependent	dependent	ADJ
dti-1306	96	23	manner	manner	NOUN
dti-1306	96	24	.	.	PUNCT
dti-1306	97	1	it	it	PRON
dti-1306	97	2	is	be	AUX
dti-1306	97	3	well	well	ADV
dti-1306	97	4	established	establish	VERB
dti-1306	97	5	that	that	SCONJ
dti-1306	97	6	egf	egf	PROPN
dti-1306	97	7	activates	activate	VERB
dti-1306	97	8	egfr	egfr	NOUN
dti-1306	97	9	.	.	PUNCT
dti-1306	98	1	several	several	ADJ
dti-1306	98	2	molecular	molecular	ADJ
dti-1306	98	3	agents	agent	NOUN
dti-1306	98	4	targeting	target	VERB
dti-1306	98	5	egfr	egfr	NOUN
dti-1306	98	6	are	be	AUX
dti-1306	98	7	undergoing	undergo	VERB
dti-1306	98	8	clinical	clinical	ADJ
dti-1306	98	9	trails	trail	NOUN
dti-1306	98	10	as	as	ADP
dti-1306	98	11	potential	potential	ADJ
dti-1306	98	12	therapies	therapy	NOUN
dti-1306	98	13	in	in	ADP
dti-1306	98	14	neurooncology	neurooncology	NOUN
dti-1306	98	15	(	(	PUNCT
dti-1306	98	16	rich	rich	ADJ
dti-1306	98	17	and	and	CCONJ
dti-1306	98	18	bigner	bigner	NOUN
dti-1306	98	19	,	,	PUNCT
dti-1306	98	20	2004	2004	NUM
dti-1306	98	21	)	)	PUNCT
dti-1306	98	22	.	.	PUNCT
dti-1306	99	1	for	for	ADP
dti-1306	99	2	example	example	NOUN
dti-1306	99	3	,	,	PUNCT
dti-1306	99	4	zd1839	zd1839	PROPN
dti-1306	99	5	(	(	PUNCT
dti-1306	99	6	iressa	iressa	NOUN
dti-1306	99	7	)	)	PUNCT
dti-1306	99	8	an	an	DET
dti-1306	99	9	orally	orally	ADV
dti-1306	99	10	active	active	ADJ
dti-1306	99	11	,	,	PUNCT
dti-1306	99	12	selective	selective	ADJ
dti-1306	99	13	egfr	egfr	ADJ
dti-1306	99	14	-	-	PUNCT
dti-1306	99	15	tyrosine	tyrosine	PROPN
dti-1306	99	16	kinase	kinase	PROPN
dti-1306	99	17	inhibitor	inhibitor	PROPN
dti-1306	99	18	has	have	VERB
dti-1306	99	19	anti	anti	ADJ
dti-1306	99	20	-	-	ADJ
dti-1306	99	21	tumor	tumor	ADJ
dti-1306	99	22	activity	activity	NOUN
dti-1306	99	23	against	against	ADP
dti-1306	99	24	malignant	malignant	ADJ
dti-1306	99	25	human	human	ADJ
dti-1306	99	26	cancer	cancer	NOUN
dti-1306	99	27	cell	cell	NOUN
dti-1306	99	28	lines	line	NOUN
dti-1306	99	29	(	(	PUNCT
dti-1306	99	30	31	31	NUM
dti-1306	99	31	)	)	PUNCT
dti-1306	99	32	.	.	PUNCT
dti-1306	100	1	glioma	glioma	NOUN
dti-1306	100	2	cells	cell	NOUN
dti-1306	100	3	also	also	ADV
dti-1306	100	4	show	show	VERB
dti-1306	100	5	up	up	ADP
dti-1306	100	6	-	-	PUNCT
dti-1306	100	7	regulation	regulation	NOUN
dti-1306	100	8	and	and	CCONJ
dti-1306	100	9	constitutive	constitutive	ADJ
dti-1306	100	10	activation	activation	NOUN
dti-1306	100	11	of	of	ADP
dti-1306	100	12	her2	her2	PROPN
dti-1306	100	13	neu	neu	PROPN
dti-1306	100	14	,	,	PUNCT
dti-1306	100	15	and	and	CCONJ
dti-1306	100	16	its	its	PRON
dti-1306	100	17	expression	expression	NOUN
dti-1306	100	18	which	which	PRON
dti-1306	100	19	correlates	correlate	VERB
dti-1306	100	20	positively	positively	ADV
dti-1306	100	21	with	with	ADP
dti-1306	100	22	aggressive	aggressive	ADJ
dti-1306	100	23	malignancy	malignancy	NOUN
dti-1306	100	24	(	(	PUNCT
dti-1306	100	25	mellinghoff	mellinghoff	PROPN
dti-1306	100	26	et	et	PROPN
dti-1306	100	27	al	al	PROPN
dti-1306	100	28	.	.	PROPN
dti-1306	100	29	2005	2005	NUM
dti-1306	100	30	)	)	PUNCT
dti-1306	100	31	.	.	PUNCT
dti-1306	101	1	a	a	DET
dti-1306	101	2	correlation	correlation	NOUN
dti-1306	101	3	has	have	AUX
dti-1306	101	4	been	be	AUX
dti-1306	101	5	demonstrated	demonstrate	VERB
dti-1306	101	6	for	for	ADP
dti-1306	101	7	the	the	DET
dti-1306	101	8	expression	expression	NOUN
dti-1306	101	9	of	of	ADP
dti-1306	101	10	gbk	gbk	PROPN
dti-1306	101	11	/	/	SYM
dti-1306	101	12	kca	kca	PROPN
dti-1306	101	13	channels	channel	NOUN
dti-1306	101	14	and	and	CCONJ
dti-1306	101	15	her-2	her-2	NUM
dti-1306	101	16	neu	neu	NOUN
dti-1306	101	17	,	,	PUNCT
dti-1306	101	18	which	which	PRON
dti-1306	101	19	implies	imply	VERB
dti-1306	101	20	gbk	gbk	PROPN
dti-1306	101	21	/	/	SYM
dti-1306	101	22	kca	kca	PROPN
dti-1306	101	23	channels	channel	NOUN
dti-1306	101	24	as	as	ADP
dti-1306	101	25	a	a	DET
dti-1306	101	26	downstream	downstream	ADJ
dti-1306	101	27	target	target	NOUN
dti-1306	101	28	for	for	ADP
dti-1306	101	29	her-2	her-2	NUM
dti-1306	101	30	neu	neu	NOUN
dti-1306	101	31	signaling	signal	VERB
dti-1306	101	32	(	(	PUNCT
dti-1306	101	33	olsen	olsen	NOUN
dti-1306	101	34	et	et	PROPN
dti-1306	101	35	al	al	PROPN
dti-1306	101	36	.	.	PROPN
dti-1306	101	37	2004	2004	NUM
dti-1306	101	38	)	)	PUNCT
dti-1306	101	39	.	.	PUNCT
dti-1306	102	1	how	how	SCONJ
dti-1306	102	2	kca	kca	PROPN
dti-1306	102	3	channel	channel	PROPN
dti-1306	102	4	modulates	modulate	NOUN
dti-1306	102	5	egfr	egfr	X
dti-1306	102	6	tyrosine	tyrosine	PROPN
dti-1306	102	7	kinase	kinase	PROPN
dti-1306	102	8	or	or	CCONJ
dti-1306	102	9	vice	vice	NOUN
dti-1306	102	10	versa	versa	ADV
dti-1306	102	11	is	be	AUX
dti-1306	102	12	poorly	poorly	ADV
dti-1306	102	13	understood	understand	VERB
dti-1306	102	14	.	.	PUNCT
dti-1306	103	1	it	it	PRON
dti-1306	103	2	appears	appear	VERB
dti-1306	103	3	to	to	PART
dti-1306	103	4	occur	occur	VERB
dti-1306	103	5	via	via	ADP
dti-1306	103	6	changes	change	NOUN
dti-1306	103	7	in	in	ADP
dti-1306	103	8	intracellular	intracellular	ADJ
dti-1306	103	9	calcium	calcium	NOUN
dti-1306	103	10	levels	level	NOUN
dti-1306	103	11	without	without	ADP
dti-1306	103	12	change	change	NOUN
dti-1306	103	13	in	in	ADP
dti-1306	103	14	channel	channel	NOUN
dti-1306	103	15	expression	expression	NOUN
dti-1306	103	16	or	or	CCONJ
dti-1306	103	17	phosphorylation	phosphorylation	NOUN
dti-1306	103	18	(	(	PUNCT
dti-1306	103	19	weaver	weaver	NOUN
dti-1306	103	20	,	,	PUNCT
dti-1306	103	21	bomben	bomben	NOUN
dti-1306	103	22	and	and	CCONJ
dti-1306	103	23	sontheimer	sontheimer	NOUN
dti-1306	103	24	,	,	PUNCT
dti-1306	103	25	2006	2006	NUM
dti-1306	103	26	)	)	PUNCT
dti-1306	103	27	.	.	PUNCT
dti-1306	104	1	in	in	ADP
dti-1306	104	2	a	a	DET
dti-1306	104	3	transgenic	transgenic	NOUN
dti-1306	104	4	glioma	glioma	NOUN
dti-1306	104	5	mouse	mouse	NOUN
dti-1306	104	6	model	model	NOUN
dti-1306	104	7	,	,	PUNCT
dti-1306	104	8	a	a	DET
dti-1306	104	9	loss	loss	NOUN
dti-1306	104	10	of	of	ADP
dti-1306	104	11	egfr	egfr	ADJ
dti-1306	104	12	overexpression	overexpression	NOUN
dti-1306	104	13	was	be	AUX
dti-1306	104	14	observed	observe	VERB
dti-1306	104	15	by	by	ADP
dti-1306	104	16	egfrviii	egfrviii	NOUN
dti-1306	104	17	introduction	introduction	NOUN
dti-1306	104	18	201	201	NUM
dti-1306	104	19	targeted	target	VERB
dti-1306	104	20	brain	brain	NOUN
dti-1306	104	21	tumor	tumor	NOUN
dti-1306	104	22	treatment	treatment	NOUN
dti-1306	104	23	drug	drug	NOUN
dti-1306	104	24	target	target	NOUN
dti-1306	104	25	insights	insight	NOUN
dti-1306	104	26	2007	2007	NUM
dti-1306	104	27	:	:	SYM
dti-1306	104	28	2	2	NUM
dti-1306	104	29	(	(	PUNCT
dti-1306	104	30	gullick	gullick	PROPN
dti-1306	104	31	,	,	PUNCT
dti-1306	104	32	2001	2001	NUM
dti-1306	104	33	)	)	PUNCT
dti-1306	104	34	.	.	PUNCT
dti-1306	105	1	this	this	DET
dti-1306	105	2	model	model	NOUN
dti-1306	105	3	of	of	ADP
dti-1306	105	4	high	high	ADJ
dti-1306	105	5	grade	grade	NOUN
dti-1306	105	6	glioma	glioma	NOUN
dti-1306	105	7	is	be	AUX
dti-1306	105	8	useful	useful	ADJ
dti-1306	105	9	in	in	ADP
dti-1306	105	10	evaluating	evaluate	VERB
dti-1306	105	11	targeted	target	VERB
dti-1306	105	12	molecular	molecular	ADJ
dti-1306	105	13	therapies	therapy	NOUN
dti-1306	105	14	in	in	ADP
dti-1306	105	15	brain	brain	NOUN
dti-1306	105	16	tumor	tumor	NOUN
dti-1306	105	17	.	.	PUNCT
dti-1306	106	1	targeting	target	VERB
dti-1306	106	2	angiogenesis	angiogenesis	NOUN
dti-1306	106	3	in	in	ADP
dti-1306	106	4	brain	brain	NOUN
dti-1306	106	5	tumors	tumor	NOUN
dti-1306	106	6	angiogenesis	angiogenesis	NOUN
dti-1306	106	7	plays	play	VERB
dti-1306	106	8	a	a	DET
dti-1306	106	9	crucial	crucial	ADJ
dti-1306	106	10	role	role	NOUN
dti-1306	106	11	in	in	ADP
dti-1306	106	12	malignant	malignant	ADJ
dti-1306	106	13	primary	primary	ADJ
dti-1306	106	14	brain	brain	NOUN
dti-1306	106	15	tumor	tumor	NOUN
dti-1306	106	16	growth	growth	NOUN
dti-1306	106	17	.	.	PUNCT
dti-1306	107	1	several	several	ADJ
dti-1306	107	2	preclinical	preclinical	ADJ
dti-1306	107	3	and	and	CCONJ
dti-1306	107	4	clinical	clinical	ADJ
dti-1306	107	5	studies	study	NOUN
dti-1306	107	6	have	have	AUX
dti-1306	107	7	confirmed	confirm	VERB
dti-1306	107	8	that	that	SCONJ
dti-1306	107	9	the	the	DET
dti-1306	107	10	vascular	vascular	ADJ
dti-1306	107	11	endothelial	endothelial	NOUN
dti-1306	107	12	cell	cell	NOUN
dti-1306	107	13	growth	growth	NOUN
dti-1306	107	14	factor	factor	NOUN
dti-1306	107	15	(	(	PUNCT
dti-1306	107	16	vegf	vegf	PROPN
dti-1306	107	17	)	)	PUNCT
dti-1306	107	18	and	and	CCONJ
dti-1306	107	19	the	the	DET
dti-1306	107	20	bfgf	bfgf	NOUN
dti-1306	107	21	bind	bind	NOUN
dti-1306	107	22	to	to	ADP
dti-1306	107	23	their	their	PRON
dti-1306	107	24	receptors	receptor	NOUN
dti-1306	107	25	to	to	PART
dti-1306	107	26	promote	promote	VERB
dti-1306	107	27	glioma	glioma	NOUN
dti-1306	107	28	growth	growth	NOUN
dti-1306	107	29	.	.	PUNCT
dti-1306	108	1	vegfr	vegfr	NOUN
dti-1306	108	2	is	be	AUX
dti-1306	108	3	expressed	express	VERB
dti-1306	108	4	in	in	ADP
dti-1306	108	5	human	human	ADJ
dti-1306	108	6	high	high	ADJ
dti-1306	108	7	grade	grade	NOUN
dti-1306	108	8	glioma	glioma	NOUN
dti-1306	108	9	but	but	CCONJ
dti-1306	108	10	not	not	PART
dti-1306	108	11	found	find	VERB
dti-1306	108	12	in	in	ADP
dti-1306	108	13	normal	normal	ADJ
dti-1306	108	14	brain	brain	NOUN
dti-1306	108	15	.	.	PUNCT
dti-1306	109	1	increased	increase	VERB
dti-1306	109	2	concentration	concentration	NOUN
dti-1306	109	3	of	of	ADP
dti-1306	109	4	angiogenic	angiogenic	ADJ
dti-1306	109	5	factors	factor	NOUN
dti-1306	109	6	and	and	CCONJ
dti-1306	109	7	their	their	PRON
dti-1306	109	8	receptors	receptor	NOUN
dti-1306	109	9	is	be	AUX
dti-1306	109	10	correlated	correlate	VERB
dti-1306	109	11	with	with	ADP
dti-1306	109	12	tumor	tumor	NOUN
dti-1306	109	13	vasculature	vasculature	NOUN
dti-1306	109	14	and	and	CCONJ
dti-1306	109	15	malignant	malignant	ADJ
dti-1306	109	16	human	human	ADJ
dti-1306	109	17	gliomas	glioma	NOUN
dti-1306	109	18	.	.	PUNCT
dti-1306	110	1	furthermore	furthermore	ADV
dti-1306	110	2	,	,	PUNCT
dti-1306	110	3	it	it	PRON
dti-1306	110	4	is	be	AUX
dti-1306	110	5	shown	show	VERB
dti-1306	110	6	that	that	SCONJ
dti-1306	110	7	the	the	DET
dti-1306	110	8	endogenous	endogenous	ADJ
dti-1306	110	9	inhibitor	inhibitor	NOUN
dti-1306	110	10	of	of	ADP
dti-1306	110	11	angiogenesis	angiogenesis	NOUN
dti-1306	110	12	,	,	PUNCT
dti-1306	110	13	thrombospondin-1	thrombospondin-1	NUM
dti-1306	110	14	(	(	PUNCT
dti-1306	110	15	tsp-1	tsp-1	NUM
dti-1306	110	16	)	)	PUNCT
dti-1306	110	17	is	be	AUX
dti-1306	110	18	produced	produce	VERB
dti-1306	110	19	by	by	ADP
dti-1306	110	20	normal	normal	ADJ
dti-1306	110	21	brain	brain	NOUN
dti-1306	110	22	and	and	CCONJ
dti-1306	110	23	low	low	ADJ
dti-1306	110	24	grade	grade	NOUN
dti-1306	110	25	gliomas	glioma	NOUN
dti-1306	110	26	,	,	PUNCT
dti-1306	110	27	but	but	CCONJ
dti-1306	110	28	is	be	AUX
dti-1306	110	29	completely	completely	ADV
dti-1306	110	30	absent	absent	ADJ
dti-1306	110	31	in	in	ADP
dti-1306	110	32	high	high	ADJ
dti-1306	110	33	grade	grade	NOUN
dti-1306	110	34	gliomas	glioma	NOUN
dti-1306	110	35	.	.	PUNCT
dti-1306	111	1	the	the	DET
dti-1306	111	2	gbm	gbm	PROPN
dti-1306	111	3	is	be	AUX
dti-1306	111	4	among	among	ADP
dti-1306	111	5	the	the	DET
dti-1306	111	6	most	most	ADJ
dti-1306	111	7	“	"	PUNCT
dti-1306	111	8	endothelial	endothelial	ADJ
dti-1306	111	9	rich	rich	ADJ
dti-1306	111	10	”	"	PUNCT
dti-1306	111	11	brain	brain	NOUN
dti-1306	111	12	tumors	tumor	NOUN
dti-1306	111	13	studied	study	VERB
dti-1306	111	14	.	.	PUNCT
dti-1306	112	1	in	in	ADP
dti-1306	112	2	children	child	NOUN
dti-1306	112	3	with	with	ADP
dti-1306	112	4	brain	brain	NOUN
dti-1306	112	5	tumors	tumor	NOUN
dti-1306	112	6	,	,	PUNCT
dti-1306	112	7	microvascular	microvascular	ADJ
dti-1306	112	8	density	density	NOUN
dti-1306	112	9	correlates	correlate	VERB
dti-1306	112	10	with	with	ADP
dti-1306	112	11	tumor	tumor	NOUN
dti-1306	112	12	recurrence	recurrence	NOUN
dti-1306	112	13	,	,	PUNCT
dti-1306	112	14	and	and	CCONJ
dti-1306	112	15	patient	patient	ADJ
dti-1306	112	16	mortality	mortality	NOUN
dti-1306	112	17	.	.	PUNCT
dti-1306	113	1	as	as	SCONJ
dti-1306	113	2	tumor	tumor	NOUN
dti-1306	113	3	vascularity	vascularity	NOUN
dti-1306	113	4	is	be	AUX
dti-1306	113	5	highly	highly	ADV
dti-1306	113	6	correlated	correlate	VERB
dti-1306	113	7	with	with	ADP
dti-1306	113	8	disease	disease	NOUN
dti-1306	113	9	outcome	outcome	NOUN
dti-1306	113	10	in	in	ADP
dti-1306	113	11	neuroblastoma	neuroblastoma	NOUN
dti-1306	113	12	,	,	PUNCT
dti-1306	113	13	novel	novel	ADJ
dti-1306	113	14	therapeutic	therapeutic	ADJ
dti-1306	113	15	that	that	PRON
dti-1306	113	16	targets	target	VERB
dti-1306	113	17	the	the	DET
dti-1306	113	18	vascular	vascular	ADJ
dti-1306	113	19	endothelium	endothelium	NOUN
dti-1306	113	20	is	be	AUX
dti-1306	113	21	a	a	DET
dti-1306	113	22	suitable	suitable	ADJ
dti-1306	113	23	clinical	clinical	ADJ
dti-1306	113	24	trial	trial	NOUN
dti-1306	113	25	target	target	NOUN
dti-1306	113	26	candidate	candidate	NOUN
dti-1306	113	27	.	.	PUNCT
dti-1306	114	1	the	the	DET
dti-1306	114	2	molecules	molecule	NOUN
dti-1306	114	3	like	like	ADP
dti-1306	114	4	vegf	vegf	PROPN
dti-1306	114	5	,	,	PUNCT
dti-1306	114	6	bfgf	bfgf	NOUN
dti-1306	114	7	,	,	PUNCT
dti-1306	114	8	pdgf	pdgf	VERB
dti-1306	114	9	as	as	ADV
dti-1306	114	10	well	well	ADV
dti-1306	114	11	as	as	ADP
dti-1306	114	12	endothelial	endothelial	ADJ
dti-1306	114	13	integrins	integrin	NOUN
dti-1306	114	14	are	be	AUX
dti-1306	114	15	linked	link	VERB
dti-1306	114	16	to	to	ADP
dti-1306	114	17	advanced	advanced	ADJ
dti-1306	114	18	malignancy	malignancy	NOUN
dti-1306	114	19	,	,	PUNCT
dti-1306	114	20	which	which	PRON
dti-1306	114	21	provided	provide	VERB
dti-1306	114	22	the	the	DET
dti-1306	114	23	rationale	rationale	NOUN
dti-1306	114	24	for	for	ADP
dti-1306	114	25	developing	develop	VERB
dti-1306	114	26	anti	anti	ADJ
dti-1306	114	27	-	-	ADJ
dti-1306	114	28	angiogenic	angiogenic	ADJ
dti-1306	114	29	therapies	therapy	NOUN
dti-1306	114	30	in	in	ADP
dti-1306	114	31	brain	brain	NOUN
dti-1306	114	32	tumors	tumor	NOUN
dti-1306	114	33	.	.	PUNCT
dti-1306	115	1	the	the	DET
dti-1306	115	2	potential	potential	NOUN
dti-1306	115	3	of	of	ADP
dti-1306	115	4	anti	anti	ADJ
dti-1306	115	5	-	-	ADJ
dti-1306	115	6	angiogenic	angiogenic	ADJ
dti-1306	115	7	therapy	therapy	NOUN
dti-1306	115	8	in	in	ADP
dti-1306	115	9	human	human	ADJ
dti-1306	115	10	brain	brain	NOUN
dti-1306	115	11	tumors	tumor	NOUN
dti-1306	115	12	is	be	AUX
dti-1306	115	13	demonstrated	demonstrate	VERB
dti-1306	115	14	in	in	ADP
dti-1306	115	15	experimental	experimental	ADJ
dti-1306	115	16	brain	brain	NOUN
dti-1306	115	17	tumor	tumor	NOUN
dti-1306	115	18	models	model	NOUN
dti-1306	115	19	.	.	PUNCT
dti-1306	116	1	a	a	DET
dti-1306	116	2	wide	wide	ADJ
dti-1306	116	3	range	range	NOUN
dti-1306	116	4	of	of	ADP
dti-1306	116	5	anti	anti	ADJ
dti-1306	116	6	-	-	ADJ
dti-1306	116	7	angiogenic	angiogenic	ADJ
dti-1306	116	8	agents	agent	NOUN
dti-1306	116	9	such	such	ADJ
dti-1306	116	10	as	as	ADP
dti-1306	116	11	endogenous	endogenous	ADJ
dti-1306	116	12	angiogenesis	angiogenesis	NOUN
dti-1306	116	13	inhibitors	inhibitor	NOUN
dti-1306	116	14	,	,	PUNCT
dti-1306	116	15	synthetic	synthetic	ADJ
dti-1306	116	16	angiogenic	angiogenic	ADJ
dti-1306	116	17	inhibitors	inhibitor	NOUN
dti-1306	116	18	,	,	PUNCT
dti-1306	116	19	antibodies	antibodie	VERB
dti-1306	116	20	,	,	PUNCT
dti-1306	116	21	and	and	CCONJ
dti-1306	116	22	anti	anti	ADJ
dti-1306	116	23	-	-	ADJ
dti-1306	116	24	angiogenic	angiogenic	ADJ
dti-1306	116	25	gene	gene	NOUN
dti-1306	116	26	therapy	therapy	NOUN
dti-1306	116	27	are	be	AUX
dti-1306	116	28	investigated	investigate	VERB
dti-1306	116	29	with	with	ADP
dti-1306	116	30	radiation	radiation	NOUN
dti-1306	116	31	therapy	therapy	NOUN
dti-1306	116	32	.	.	PUNCT
dti-1306	117	1	anti	anti	ADJ
dti-1306	117	2	-	-	ADJ
dti-1306	117	3	angiogenic	angiogenic	ADJ
dti-1306	117	4	drugs	drug	NOUN
dti-1306	117	5	have	have	VERB
dti-1306	117	6	low	low	ADJ
dti-1306	117	7	potential	potential	NOUN
dti-1306	117	8	for	for	ADP
dti-1306	117	9	toxicity	toxicity	NOUN
dti-1306	117	10	and	and	CCONJ
dti-1306	117	11	resistance	resistance	NOUN
dti-1306	117	12	because	because	SCONJ
dti-1306	117	13	they	they	PRON
dti-1306	117	14	specifi	specifi	AUX
dti-1306	117	15	cally	cally	ADV
dti-1306	117	16	target	target	VERB
dti-1306	117	17	endothelial	endothelial	ADJ
dti-1306	117	18	cells	cell	NOUN
dti-1306	117	19	.	.	PUNCT
dti-1306	118	1	the	the	DET
dti-1306	118	2	potential	potential	NOUN
dti-1306	118	3	of	of	ADP
dti-1306	118	4	antiangiogenic	antiangiogenic	ADJ
dti-1306	118	5	agents	agent	NOUN
dti-1306	118	6	to	to	PART
dti-1306	118	7	augment	augment	VERB
dti-1306	118	8	the	the	DET
dti-1306	118	9	anti	anti	ADJ
dti-1306	118	10	-	-	ADJ
dti-1306	118	11	tumor	tumor	ADJ
dti-1306	118	12	activity	activity	NOUN
dti-1306	118	13	of	of	ADP
dti-1306	118	14	standard	standard	ADJ
dti-1306	118	15	cytotoxic	cytotoxic	ADJ
dti-1306	118	16	chemotherapeutic	chemotherapeutic	ADJ
dti-1306	118	17	agents	agent	NOUN
dti-1306	118	18	is	be	AUX
dti-1306	118	19	being	be	AUX
dti-1306	118	20	investigated	investigate	VERB
dti-1306	118	21	(	(	PUNCT
dti-1306	118	22	bernsen	bernsen	NUM
dti-1306	118	23	and	and	CCONJ
dti-1306	118	24	van	van	PROPN
dti-1306	118	25	der	der	NOUN
dti-1306	118	26	kogel	kogel	NOUN
dti-1306	118	27	,	,	PUNCT
dti-1306	118	28	1999	1999	NUM
dti-1306	118	29	;	;	PUNCT
dti-1306	118	30	reijneveld	reijneveld	VERB
dti-1306	118	31	,	,	PUNCT
dti-1306	118	32	voest	vo	ADJ
dti-1306	118	33	and	and	CCONJ
dti-1306	118	34	taphoorn	taphoorn	VERB
dti-1306	118	35	,	,	PUNCT
dti-1306	118	36	2000	2000	NUM
dti-1306	118	37	;	;	PUNCT
dti-1306	118	38	takano	takano	PROPN
dti-1306	118	39	et	et	PROPN
dti-1306	118	40	al	al	PROPN
dti-1306	118	41	.	.	PROPN
dti-1306	118	42	2004	2004	NUM
dti-1306	118	43	)	)	PUNCT
dti-1306	118	44	.	.	PUNCT
dti-1306	119	1	the	the	DET
dti-1306	119	2	evidence	evidence	NOUN
dti-1306	119	3	for	for	ADP
dti-1306	119	4	glioma	glioma	ADJ
dti-1306	119	5	anti	anti	ADJ
dti-1306	119	6	-	-	ADJ
dti-1306	119	7	angiogenesis	angiogenesis	ADJ
dti-1306	119	8	therapy	therapy	NOUN
dti-1306	119	9	,	,	PUNCT
dti-1306	119	10	with	with	ADP
dti-1306	119	11	or	or	CCONJ
dti-1306	119	12	without	without	ADP
dti-1306	119	13	chemotherapy	chemotherapy	NOUN
dti-1306	119	14	has	have	AUX
dti-1306	119	15	been	be	AUX
dti-1306	119	16	described	describe	VERB
dti-1306	119	17	in	in	ADP
dti-1306	119	18	several	several	ADJ
dti-1306	119	19	preclinical	preclinical	ADJ
dti-1306	119	20	animal	animal	NOUN
dti-1306	119	21	models	model	NOUN
dti-1306	119	22	.	.	PUNCT
dti-1306	120	1	the	the	DET
dti-1306	120	2	anti	anti	ADJ
dti-1306	120	3	-	-	ADJ
dti-1306	120	4	angiogenic	angiogenic	ADJ
dti-1306	120	5	function	function	NOUN
dti-1306	120	6	of	of	ADP
dti-1306	120	7	tsp-1	tsp-1	NUM
dti-1306	120	8	is	be	AUX
dti-1306	120	9	known	know	VERB
dti-1306	120	10	for	for	ADP
dti-1306	120	11	a	a	DET
dti-1306	120	12	long	long	ADJ
dti-1306	120	13	time	time	NOUN
dti-1306	120	14	.	.	PUNCT
dti-1306	121	1	the	the	DET
dti-1306	121	2	tsp-1	tsp-1	ADP
dti-1306	121	3	transfected	transfecte	VERB
dti-1306	121	4	glioma	glioma	NOUN
dti-1306	121	5	cells	cell	NOUN
dti-1306	121	6	lacked	lack	VERB
dti-1306	121	7	vegf	vegf	NOUN
dti-1306	121	8	expression	expression	NOUN
dti-1306	121	9	ability	ability	NOUN
dti-1306	121	10	,	,	PUNCT
dti-1306	121	11	which	which	PRON
dti-1306	121	12	supports	support	VERB
dti-1306	121	13	the	the	DET
dti-1306	121	14	rationale	rationale	NOUN
dti-1306	121	15	for	for	ADP
dti-1306	121	16	using	use	VERB
dti-1306	121	17	vegf	vegf	PROPN
dti-1306	121	18	and	and	CCONJ
dti-1306	121	19	bfgf	bfgf	PROPN
dti-1306	121	20	antibodies	antibodie	VERB
dti-1306	121	21	in	in	ADP
dti-1306	121	22	clinical	clinical	ADJ
dti-1306	121	23	trails	trail	NOUN
dti-1306	121	24	.	.	PUNCT
dti-1306	122	1	anti	anti	ADJ
dti-1306	122	2	-	-	ADJ
dti-1306	122	3	angiogenic	angiogenic	ADJ
dti-1306	122	4	drug	drug	NOUN
dti-1306	122	5	,	,	PUNCT
dti-1306	122	6	thal	thal	PROPN
dti-1306	122	7	idomide	idomide	PROPN
dti-1306	122	8	exhibi	exhibi	PROPN
dti-1306	122	9	ts	ts	ADP
dti-1306	122	10	synergis	synergis	PROPN
dti-1306	122	11	t	t	PROPN
dti-1306	122	12	ic	ic	PROPN
dti-1306	122	13	anti	anti	ADJ
dti-1306	122	14	-	-	ADJ
dti-1306	122	15	glioma	glioma	ADJ
dti-1306	122	16	activity	activity	NOUN
dti-1306	122	17	when	when	SCONJ
dti-1306	122	18	combined	combine	VERB
dti-1306	122	19	with	with	ADP
dti-1306	122	20	dna	dna	NOUN
dti-1306	122	21	alkylating	alkylate	VERB
dti-1306	122	22	agent	agent	NOUN
dti-1306	122	23	temozolomide	temozolomide	NOUN
dti-1306	122	24	,	,	PUNCT
dti-1306	122	25	and	and	CCONJ
dti-1306	122	26	increased	increase	VERB
dti-1306	122	27	median	median	ADJ
dti-1306	122	28	survival	survival	NOUN
dti-1306	122	29	from	from	ADP
dti-1306	122	30	63	63	NUM
dti-1306	122	31	weeks	week	NOUN
dti-1306	122	32	to	to	ADP
dti-1306	122	33	103	103	NUM
dti-1306	122	34	weeks	week	NOUN
dti-1306	122	35	compared	compare	VERB
dti-1306	122	36	to	to	PART
dti-1306	122	37	thalidomide	thalidomide	VERB
dti-1306	122	38	only	only	ADV
dti-1306	122	39	group	group	NOUN
dti-1306	122	40	(	(	PUNCT
dti-1306	122	41	baumann	baumann	PROPN
dti-1306	122	42	et	et	PROPN
dti-1306	122	43	al	al	PROPN
dti-1306	122	44	.	.	PROPN
dti-1306	122	45	2004	2004	NUM
dti-1306	122	46	)	)	PUNCT
dti-1306	122	47	.	.	PUNCT
dti-1306	123	1	while	while	SCONJ
dti-1306	123	2	evaluating	evaluate	VERB
dti-1306	123	3	anti	anti	ADJ
dti-1306	123	4	-	-	ADJ
dti-1306	123	5	angiogenic	angiogenic	ADJ
dti-1306	123	6	drugs	drug	NOUN
dti-1306	123	7	for	for	ADP
dti-1306	123	8	clinical	clinical	ADJ
dti-1306	123	9	development	development	NOUN
dti-1306	123	10	,	,	PUNCT
dti-1306	123	11	it	it	PRON
dti-1306	123	12	is	be	AUX
dti-1306	123	13	important	important	ADJ
dti-1306	123	14	to	to	PART
dti-1306	123	15	analyze	analyze	VERB
dti-1306	123	16	if	if	SCONJ
dti-1306	123	17	such	such	ADJ
dti-1306	123	18	drugs	drug	NOUN
dti-1306	123	19	penetrate	penetrate	VERB
dti-1306	123	20	the	the	DET
dti-1306	123	21	bbb	bbb	NOUN
dti-1306	123	22	,	,	PUNCT
dti-1306	123	23	and	and	CCONJ
dti-1306	123	24	survive	survive	VERB
dti-1306	123	25	p	p	NOUN
dti-1306	123	26	-	-	PUNCT
dti-1306	123	27	glycoprotein	glycoprotein	NOUN
dti-1306	123	28	-	-	PUNCT
dti-1306	123	29	mediated	mediate	VERB
dti-1306	123	30	drug	drug	NOUN
dti-1306	123	31	efflux	efflux	NOUN
dti-1306	123	32	system	system	NOUN
dti-1306	123	33	.	.	PUNCT
dti-1306	124	1	at	at	ADP
dti-1306	124	2	present	present	ADJ
dti-1306	124	3	,	,	PUNCT
dti-1306	124	4	there	there	PRON
dti-1306	124	5	is	be	VERB
dti-1306	124	6	a	a	DET
dti-1306	124	7	great	great	ADJ
dti-1306	124	8	deal	deal	NOUN
dti-1306	124	9	of	of	ADP
dti-1306	124	10	interest	interest	NOUN
dti-1306	124	11	in	in	ADP
dti-1306	124	12	combination	combination	NOUN
dti-1306	124	13	therapy	therapy	NOUN
dti-1306	124	14	using	use	VERB
dti-1306	124	15	conventional	conventional	ADJ
dti-1306	124	16	cytotoxic	cytotoxic	ADJ
dti-1306	124	17	therapy	therapy	NOUN
dti-1306	124	18	with	with	ADP
dti-1306	124	19	chemotherapeutics	chemotherapeutic	NOUN
dti-1306	124	20	and	and	CCONJ
dti-1306	124	21	radiotherapy	radiotherapy	NOUN
dti-1306	124	22	.	.	PUNCT
dti-1306	125	1	anti	anti	ADJ
dti-1306	125	2	-	-	ADJ
dti-1306	125	3	angiogenic	angiogenic	ADJ
dti-1306	125	4	agents	agent	NOUN
dti-1306	125	5	like	like	ADP
dti-1306	125	6	tnp-470	tnp-470	NOUN
dti-1306	125	7	,	,	PUNCT
dti-1306	125	8	angiostatin	angiostatin	NOUN
dti-1306	125	9	,	,	PUNCT
dti-1306	125	10	dc	dc	PROPN
dti-1306	125	11	101	101	NUM
dti-1306	125	12	,	,	PUNCT
dti-1306	125	13	su5416	su5416	PROPN
dti-1306	125	14	,	,	PUNCT
dti-1306	125	15	anti	anti	ADJ
dti-1306	125	16	-	-	ADJ
dti-1306	125	17	vegf	vegf	NOUN
dti-1306	125	18	and	and	CCONJ
dti-1306	125	19	vegf	vegf	PROPN
dti-1306	125	20	-	-	PUNCT
dti-1306	125	21	r	r	NOUN
dti-1306	125	22	antibodies	antibody	NOUN
dti-1306	125	23	and	and	CCONJ
dti-1306	125	24	vegf	vegf	NOUN
dti-1306	125	25	monoclonal	monoclonal	NOUN
dti-1306	125	26	antibody	antibody	NOUN
dti-1306	125	27	a4.6.1	a4.6.1	PROPN
dti-1306	125	28	,	,	PUNCT
dti-1306	125	29	tyrosine	tyrosine	NOUN
dti-1306	125	30	kinase	kinase	PROPN
dti-1306	125	31	inhibitors	inhibitor	NOUN
dti-1306	125	32	,	,	PUNCT
dti-1306	125	33	cox-2	cox-2	ADJ
dti-1306	125	34	inhibitors	inhibitor	NOUN
dti-1306	125	35	,	,	PUNCT
dti-1306	125	36	and	and	CCONJ
dti-1306	125	37	anti	anti	ADJ
dti-1306	125	38	-	-	ADJ
dti-1306	125	39	egfr	egfr	ADJ
dti-1306	125	40	inhibitors	inhibitor	NOUN
dti-1306	125	41	are	be	AUX
dti-1306	125	42	used	use	VERB
dti-1306	125	43	in	in	ADP
dti-1306	125	44	combination	combination	NOUN
dti-1306	125	45	with	with	ADP
dti-1306	125	46	radiation	radiation	NOUN
dti-1306	125	47	.	.	PUNCT
dti-1306	126	1	the	the	DET
dti-1306	126	2	synthetic	synthetic	ADJ
dti-1306	126	3	fumagillin	fumagillin	PROPN
dti-1306	126	4	analogue	analogue	NOUN
dti-1306	126	5	,	,	PUNCT
dti-1306	126	6	tnp-470	tnp-470	NOUN
dti-1306	126	7	was	be	AUX
dti-1306	126	8	shown	show	VERB
dti-1306	126	9	to	to	PART
dti-1306	126	10	interfere	interfere	VERB
dti-1306	126	11	with	with	ADP
dti-1306	126	12	angiogenesis	angiogenesis	NOUN
dti-1306	126	13	through	through	ADP
dti-1306	126	14	inhibition	inhibition	NOUN
dti-1306	126	15	of	of	ADP
dti-1306	126	16	endothelial	endothelial	ADJ
dti-1306	126	17	cell	cell	NOUN
dti-1306	126	18	proliferation	proliferation	NOUN
dti-1306	126	19	and	and	CCONJ
dti-1306	126	20	migration	migration	NOUN
dti-1306	126	21	in	in	ADP
dti-1306	126	22	murine	murine	ADJ
dti-1306	126	23	and	and	CCONJ
dti-1306	126	24	human	human	ADJ
dti-1306	126	25	neuroblastoma	neuroblastoma	PROPN
dti-1306	126	26	xenograft	xenograft	NOUN
dti-1306	126	27	model	model	PROPN
dti-1306	126	28	.	.	PUNCT
dti-1306	127	1	now	now	ADV
dti-1306	127	2	it	it	PRON
dti-1306	127	3	is	be	AUX
dti-1306	127	4	being	be	AUX
dti-1306	127	5	evaluated	evaluate	VERB
dti-1306	127	6	in	in	ADP
dti-1306	127	7	phase	phase	NOUN
dti-1306	127	8	i	i	PROPN
dti-1306	127	9	/	/	SYM
dti-1306	127	10	ii	ii	PROPN
dti-1306	127	11	clinical	clinical	ADJ
dti-1306	127	12	trials	trial	NOUN
dti-1306	127	13	.	.	PUNCT
dti-1306	128	1	in	in	ADP
dti-1306	128	2	brain	brain	NOUN
dti-1306	128	3	tumor	tumor	NOUN
dti-1306	128	4	models	model	NOUN
dti-1306	128	5	,	,	PUNCT
dti-1306	128	6	tnp470	tnp470	NOUN
dti-1306	128	7	and	and	CCONJ
dti-1306	128	8	minocycline	minocycline	NOUN
dti-1306	128	9	together	together	ADV
dti-1306	128	10	increased	increase	VERB
dti-1306	128	11	9l	9l	NUM
dti-1306	128	12	glioma	glioma	NOUN
dti-1306	128	13	sensitivity	sensitivity	NOUN
dti-1306	128	14	to	to	PART
dti-1306	128	15	bcnu	bcnu	VERB
dti-1306	128	16	and	and	CCONJ
dti-1306	128	17	andriamycin	andriamycin	PROPN
dti-1306	128	18	(	(	PUNCT
dti-1306	128	19	shusterman	shusterman	NOUN
dti-1306	128	20	et	et	PROPN
dti-1306	128	21	al	al	PROPN
dti-1306	128	22	.	.	PROPN
dti-1306	128	23	2001	2001	NUM
dti-1306	128	24	)	)	PUNCT
dti-1306	128	25	,	,	PUNCT
dti-1306	128	26	while	while	SCONJ
dti-1306	128	27	lund	lund	PROPN
dti-1306	128	28	,	,	PUNCT
dti-1306	128	29	bastholm	bastholm	NOUN
dti-1306	128	30	and	and	CCONJ
dti-1306	128	31	kristjansen	kristjansen	ADJ
dti-1306	128	32	,	,	PUNCT
dti-1306	128	33	(	(	PUNCT
dti-1306	128	34	2000	2000	NUM
dti-1306	128	35	)	)	PUNCT
dti-1306	128	36	found	find	VERB
dti-1306	128	37	that	that	SCONJ
dti-1306	128	38	tnp-470	tnp-470	NOUN
dti-1306	128	39	increased	increase	VERB
dti-1306	128	40	radiation	radiation	NOUN
dti-1306	128	41	sensitivity	sensitivity	NOUN
dti-1306	128	42	of	of	ADP
dti-1306	128	43	human	human	ADJ
dti-1306	128	44	u87	u87	ADJ
dti-1306	128	45	glioblastoma	glioblastoma	NOUN
dti-1306	128	46	xenografts	xenograft	NOUN
dti-1306	128	47	.	.	PUNCT
dti-1306	129	1	a	a	DET
dti-1306	129	2	phase	phase	NOUN
dti-1306	129	3	ii	ii	PROPN
dti-1306	129	4	study	study	NOUN
dti-1306	129	5	with	with	ADP
dti-1306	129	6	anti	anti	ADJ
dti-1306	129	7	-	-	ADJ
dti-1306	129	8	angiogenic	angiogenic	ADJ
dti-1306	129	9	monoclonal	monoclonal	NOUN
dti-1306	129	10	antibody	antibody	NOUN
dti-1306	129	11	bevacizumab	bevacizumab	NOUN
dti-1306	129	12	(	(	PUNCT
dti-1306	129	13	avastin	avastin	NOUN
dti-1306	129	14	)	)	PUNCT
dti-1306	129	15	and	and	CCONJ
dti-1306	129	16	anti	anti	ADJ
dti-1306	129	17	-	-	ADJ
dti-1306	129	18	cytokine	cytokine	ADJ
dti-1306	129	19	irinotecan	irinotecan	NOUN
dti-1306	129	20	in	in	ADP
dti-1306	129	21	brain	brain	NOUN
dti-1306	129	22	tumor	tumor	NOUN
dti-1306	129	23	patients	patient	NOUN
dti-1306	129	24	is	be	AUX
dti-1306	129	25	also	also	ADV
dti-1306	129	26	being	be	AUX
dti-1306	129	27	conducted	conduct	VERB
dti-1306	129	28	(	(	PUNCT
dti-1306	129	29	nct00381797	nct00381797	NOUN
dti-1306	129	30	)	)	PUNCT
dti-1306	129	31	.	.	PUNCT
dti-1306	130	1	endogenous	endogenous	ADJ
dti-1306	130	2	inhibitors	inhibitor	NOUN
dti-1306	130	3	of	of	ADP
dti-1306	130	4	angiogenesis	angiogenesis	NOUN
dti-1306	130	5	such	such	ADJ
dti-1306	130	6	as	as	ADP
dti-1306	130	7	angiostatin	angiostatin	NOUN
dti-1306	130	8	,	,	PUNCT
dti-1306	130	9	endostatin	endostatin	NOUN
dti-1306	130	10	,	,	PUNCT
dti-1306	130	11	pex	pex	PROPN
dti-1306	130	12	,	,	PUNCT
dti-1306	130	13	pigment	pigment	ADJ
dti-1306	130	14	epithelial	epithelial	ADJ
dti-1306	130	15	-	-	PUNCT
dti-1306	130	16	derived	derive	VERB
dti-1306	130	17	factor	factor	NOUN
dti-1306	130	18	,	,	PUNCT
dti-1306	130	19	and	and	CCONJ
dti-1306	130	20	thrombospondin	thrombospondin	VERB
dti-1306	130	21	(	(	PUNCT
dti-1306	130	22	tsp-1&2	tsp-1&2	X
dti-1306	130	23	)	)	PUNCT
dti-1306	130	24	are	be	AUX
dti-1306	130	25	shown	show	VERB
dti-1306	130	26	to	to	PART
dti-1306	130	27	be	be	AUX
dti-1306	130	28	effi	effi	PROPN
dti-1306	130	29	cacious	cacious	ADJ
dti-1306	130	30	.	.	PUNCT
dti-1306	131	1	they	they	PRON
dti-1306	131	2	exert	exert	VERB
dti-1306	131	3	their	their	PRON
dti-1306	131	4	effects	effect	NOUN
dti-1306	131	5	through	through	ADP
dti-1306	131	6	multiple	multiple	ADJ
dti-1306	131	7	mechanisms	mechanism	NOUN
dti-1306	131	8	,	,	PUNCT
dti-1306	131	9	including	include	VERB
dti-1306	131	10	induction	induction	NOUN
dti-1306	131	11	of	of	ADP
dti-1306	131	12	apoptosis	apoptosis	NOUN
dti-1306	131	13	of	of	ADP
dti-1306	131	14	micro	micro	ADJ
dti-1306	131	15	vascular	vascular	ADJ
dti-1306	131	16	endothelial	endothelial	ADJ
dti-1306	131	17	cells	cell	NOUN
dti-1306	131	18	,	,	PUNCT
dti-1306	131	19	inhibition	inhibition	NOUN
dti-1306	131	20	of	of	ADP
dti-1306	131	21	proliferation	proliferation	NOUN
dti-1306	131	22	of	of	ADP
dti-1306	131	23	endothelial	endothelial	ADJ
dti-1306	131	24	cells	cell	NOUN
dti-1306	131	25	,	,	PUNCT
dti-1306	131	26	inhibition	inhibition	NOUN
dti-1306	131	27	of	of	ADP
dti-1306	131	28	function	function	NOUN
dti-1306	131	29	,	,	PUNCT
dti-1306	131	30	and	and	CCONJ
dti-1306	131	31	regulation	regulation	NOUN
dti-1306	131	32	of	of	ADP
dti-1306	131	33	proangiogenic	proangiogenic	ADJ
dti-1306	131	34	molecules	molecule	NOUN
dti-1306	131	35	.	.	PUNCT
dti-1306	132	1	these	these	DET
dti-1306	132	2	endogenous	endogenous	ADJ
dti-1306	132	3	inhibitors	inhibitor	NOUN
dti-1306	132	4	offer	offer	VERB
dti-1306	132	5	a	a	DET
dti-1306	132	6	novel	novel	ADJ
dti-1306	132	7	treatment	treatment	NOUN
dti-1306	132	8	option	option	NOUN
dti-1306	132	9	because	because	SCONJ
dti-1306	132	10	they	they	PRON
dti-1306	132	11	are	be	AUX
dti-1306	132	12	unlikely	unlikely	ADJ
dti-1306	132	13	to	to	PART
dti-1306	132	14	trigger	trigger	VERB
dti-1306	132	15	a	a	DET
dti-1306	132	16	host	host	NOUN
dti-1306	132	17	immune	immune	ADJ
dti-1306	132	18	response	response	NOUN
dti-1306	132	19	.	.	PUNCT
dti-1306	133	1	angiostatin	angiostatin	NOUN
dti-1306	133	2	,	,	PUNCT
dti-1306	133	3	a	a	DET
dti-1306	133	4	proteolytic	proteolytic	ADJ
dti-1306	133	5	fragment	fragment	NOUN
dti-1306	133	6	of	of	ADP
dti-1306	133	7	plasminogen	plasminogen	NOUN
dti-1306	133	8	inhibits	inhibit	VERB
dti-1306	133	9	angiogenesis	angiogenesis	NOUN
dti-1306	133	10	and	and	CCONJ
dti-1306	133	11	attenuate	attenuate	VERB
dti-1306	133	12	the	the	DET
dti-1306	133	13	growth	growth	NOUN
dti-1306	133	14	of	of	ADP
dti-1306	133	15	primary	primary	ADJ
dti-1306	133	16	and	and	CCONJ
dti-1306	133	17	metastatic	metastatic	ADJ
dti-1306	133	18	tumors	tumor	NOUN
dti-1306	133	19	.	.	PUNCT
dti-1306	134	1	angiostatin	angiostatin	NOUN
dti-1306	134	2	was	be	AUX
dti-1306	134	3	effectively	effectively	ADV
dti-1306	134	4	used	use	VERB
dti-1306	134	5	in	in	ADP
dti-1306	134	6	combination	combination	NOUN
dti-1306	134	7	with	with	ADP
dti-1306	134	8	202	202	NUM
dti-1306	134	9	ningaraj	ningaraj	ADJ
dti-1306	134	10	et	et	PROPN
dti-1306	134	11	al	al	PROPN
dti-1306	134	12	drug	drug	PROPN
dti-1306	134	13	target	target	NOUN
dti-1306	134	14	insights	insight	NOUN
dti-1306	134	15	2007	2007	NUM
dti-1306	134	16	:	:	PUNCT
dti-1306	134	17	2	2	NUM
dti-1306	134	18	fractional	fractional	ADJ
dti-1306	134	19	radiation	radiation	NOUN
dti-1306	134	20	therapy	therapy	NOUN
dti-1306	134	21	in	in	ADP
dti-1306	134	22	human	human	ADJ
dti-1306	134	23	glioma	glioma	NOUN
dti-1306	134	24	models	model	NOUN
dti-1306	134	25	(	(	PUNCT
dti-1306	134	26	mauceri	mauceri	PROPN
dti-1306	134	27	et	et	PROPN
dti-1306	134	28	al	al	PROPN
dti-1306	134	29	.	.	PROPN
dti-1306	134	30	1998	1998	NUM
dti-1306	134	31	;	;	PUNCT
dti-1306	134	32	rege	rege	PROPN
dti-1306	134	33	,	,	PUNCT
dti-1306	134	34	fears	fear	NOUN
dti-1306	134	35	and	and	CCONJ
dti-1306	134	36	gladson	gladson	NOUN
dti-1306	134	37	,	,	PUNCT
dti-1306	134	38	2005	2005	NUM
dti-1306	134	39	)	)	PUNCT
dti-1306	134	40	.	.	PUNCT
dti-1306	135	1	recently	recently	ADV
dti-1306	135	2	,	,	PUNCT
dti-1306	135	3	gene	gene	NOUN
dti-1306	135	4	therapy	therapy	NOUN
dti-1306	135	5	has	have	AUX
dti-1306	135	6	hit	hit	VERB
dti-1306	135	7	a	a	DET
dti-1306	135	8	snag	snag	NOUN
dti-1306	135	9	,	,	PUNCT
dti-1306	135	10	but	but	CCONJ
dti-1306	135	11	offers	offer	VERB
dti-1306	135	12	a	a	DET
dti-1306	135	13	promising	promising	ADJ
dti-1306	135	14	alternate	alternate	ADJ
dti-1306	135	15	treatment	treatment	NOUN
dti-1306	135	16	strategy	strategy	NOUN
dti-1306	135	17	.	.	PUNCT
dti-1306	136	1	brain	brain	NOUN
dti-1306	136	2	tumors	tumor	NOUN
dti-1306	136	3	are	be	AUX
dti-1306	136	4	attractive	attractive	ADJ
dti-1306	136	5	for	for	ADP
dti-1306	136	6	gene	gene	NOUN
dti-1306	136	7	therapy	therapy	NOUN
dti-1306	136	8	because	because	SCONJ
dti-1306	136	9	the	the	DET
dti-1306	136	10	brain	brain	NOUN
dti-1306	136	11	is	be	AUX
dti-1306	136	12	an	an	DET
dti-1306	136	13	immunologically	immunologically	ADV
dti-1306	136	14	privileged	privileged	ADJ
dti-1306	136	15	organ	organ	NOUN
dti-1306	136	16	,	,	PUNCT
dti-1306	136	17	and	and	CCONJ
dti-1306	136	18	the	the	DET
dti-1306	136	19	bbb	bbb	PROPN
dti-1306	136	20	provides	provide	VERB
dti-1306	136	21	a	a	DET
dti-1306	136	22	natural	natural	ADJ
dti-1306	136	23	immunological	immunological	ADJ
dti-1306	136	24	barrier	barrier	NOUN
dti-1306	136	25	.	.	PUNCT
dti-1306	137	1	mice	mouse	NOUN
dti-1306	137	2	when	when	SCONJ
dti-1306	137	3	treated	treat	VERB
dti-1306	137	4	with	with	ADP
dti-1306	137	5	a	a	DET
dti-1306	137	6	retrovirus	retrovirus	NOUN
dti-1306	137	7	encoding	encode	VERB
dti-1306	137	8	a	a	DET
dti-1306	137	9	dominant	dominant	ADJ
dti-1306	137	10	negative	negative	ADJ
dti-1306	137	11	mutant	mutant	NOUN
dti-1306	137	12	of	of	ADP
dti-1306	137	13	the	the	DET
dti-1306	137	14	vegf	vegf	PROPN
dti-1306	137	15	receptor	receptor	NOUN
dti-1306	137	16	flk-1	flk-1	NUM
dti-1306	137	17	resulted	result	VERB
dti-1306	137	18	in	in	ADP
dti-1306	137	19	reduced	reduced	ADJ
dti-1306	137	20	tumor	tumor	NOUN
dti-1306	137	21	growth	growth	NOUN
dti-1306	137	22	and	and	CCONJ
dti-1306	137	23	decreased	decrease	VERB
dti-1306	137	24	blood	blood	NOUN
dti-1306	137	25	vessel	vessel	NOUN
dti-1306	137	26	density	density	NOUN
dti-1306	137	27	.	.	PUNCT
dti-1306	138	1	recombinant	recombinant	ADJ
dti-1306	138	2	adeno	adeno	NOUN
dti-1306	138	3	-	-	PUNCT
dti-1306	138	4	associated	associate	VERB
dti-1306	138	5	virus	virus	NOUN
dti-1306	138	6	(	(	PUNCT
dti-1306	138	7	aav	aav	NOUN
dti-1306	138	8	)	)	PUNCT
dti-1306	138	9	vector	vector	NOUN
dti-1306	138	10	with	with	ADP
dti-1306	138	11	the	the	DET
dti-1306	138	12	angiostatin	angiostatin	NOUN
dti-1306	138	13	gene	gene	NOUN
dti-1306	138	14	was	be	AUX
dti-1306	138	15	used	use	VERB
dti-1306	138	16	to	to	PART
dti-1306	138	17	reduce	reduce	VERB
dti-1306	138	18	tumor	tumor	NOUN
dti-1306	138	19	growth	growth	NOUN
dti-1306	138	20	and	and	CCONJ
dti-1306	138	21	angiogenesis	angiogenesis	NOUN
dti-1306	138	22	in	in	ADP
dti-1306	138	23	a	a	DET
dti-1306	138	24	c6	c6	PROPN
dti-1306	138	25	glioma	glioma	NOUN
dti-1306	138	26	model	model	NOUN
dti-1306	138	27	.	.	PUNCT
dti-1306	139	1	antiangiogenic	antiangiogenic	ADJ
dti-1306	139	2	therapy	therapy	NOUN
dti-1306	139	3	using	use	VERB
dti-1306	139	4	semliki	semliki	PROPN
dti-1306	139	5	forest	forest	NOUN
dti-1306	139	6	virus	virus	NOUN
dti-1306	139	7	(	(	PUNCT
dti-1306	139	8	sfv	sfv	PROPN
dti-1306	139	9	)	)	PUNCT
dti-1306	139	10	carrying	carry	VERB
dti-1306	139	11	endostatin	endostatin	NOUN
dti-1306	139	12	gene	gene	NOUN
dti-1306	139	13	significantly	significantly	ADV
dti-1306	139	14	reduced	reduce	VERB
dti-1306	139	15	the	the	DET
dti-1306	139	16	tumor	tumor	NOUN
dti-1306	139	17	growth	growth	NOUN
dti-1306	139	18	in	in	ADP
dti-1306	139	19	animals	animal	NOUN
dti-1306	139	20	.	.	PUNCT
dti-1306	140	1	therefore	therefore	ADV
dti-1306	140	2	,	,	PUNCT
dti-1306	140	3	gene	gene	NOUN
dti-1306	140	4	therapy	therapy	NOUN
dti-1306	140	5	with	with	ADP
dti-1306	140	6	endostatin	endostatin	NOUN
dti-1306	140	7	delivered	deliver	VERB
dti-1306	140	8	via	via	ADP
dti-1306	140	9	sfv	sfv	PROPN
dti-1306	140	10	may	may	AUX
dti-1306	140	11	be	be	AUX
dti-1306	140	12	a	a	DET
dti-1306	140	13	viable	viable	ADJ
dti-1306	140	14	treatment	treatment	NOUN
dti-1306	140	15	strategy	strategy	NOUN
dti-1306	140	16	for	for	ADP
dti-1306	140	17	brain	brain	NOUN
dti-1306	140	18	tumors	tumor	NOUN
dti-1306	140	19	(	(	PUNCT
dti-1306	140	20	ma	ma	PROPN
dti-1306	140	21	et	et	PROPN
dti-1306	140	22	al	al	PROPN
dti-1306	140	23	.	.	PROPN
dti-1306	140	24	2002	2002	NUM
dti-1306	140	25	;	;	PUNCT
dti-1306	140	26	yamanaka	yamanaka	PROPN
dti-1306	140	27	et	et	PROPN
dti-1306	140	28	al	al	PROPN
dti-1306	140	29	.	.	PROPN
dti-1306	140	30	2003	2003	NUM
dti-1306	140	31	)	)	PUNCT
dti-1306	140	32	.	.	PUNCT
dti-1306	141	1	although	although	SCONJ
dti-1306	141	2	,	,	PUNCT
dti-1306	141	3	the	the	DET
dti-1306	141	4	gene	gene	NOUN
dti-1306	141	5	therapy	therapy	NOUN
dti-1306	141	6	in	in	ADP
dti-1306	141	7	general	general	ADJ
dti-1306	141	8	is	be	AUX
dti-1306	141	9	in	in	ADP
dti-1306	141	10	its	its	PRON
dti-1306	141	11	infancy	infancy	NOUN
dti-1306	141	12	,	,	PUNCT
dti-1306	141	13	it	it	PRON
dti-1306	141	14	provides	provide	VERB
dti-1306	141	15	an	an	DET
dti-1306	141	16	alternate	alternate	ADJ
dti-1306	141	17	strategy	strategy	NOUN
dti-1306	141	18	to	to	PART
dti-1306	141	19	treat	treat	VERB
dti-1306	141	20	hard	hard	ADV
dti-1306	141	21	-	-	PUNCT
dti-1306	141	22	to	to	PART
dti-1306	141	23	treat	treat	VERB
dti-1306	141	24	brain	brain	NOUN
dti-1306	141	25	tumors	tumor	NOUN
dti-1306	141	26	.	.	PUNCT
dti-1306	142	1	epigenetic	epigenetic	ADJ
dti-1306	142	2	genes	gene	NOUN
dti-1306	142	3	as	as	SCONJ
dti-1306	142	4	brain	brain	NOUN
dti-1306	142	5	tumor	tumor	NOUN
dti-1306	142	6	targets	target	VERB
dti-1306	142	7	epigenetic	epigenetic	ADJ
dti-1306	142	8	events	event	NOUN
dti-1306	142	9	are	be	AUX
dti-1306	142	10	genetic	genetic	ADJ
dti-1306	142	11	modifi	modifi	NOUN
dti-1306	142	12	cations	cation	NOUN
dti-1306	142	13	(	(	PUNCT
dti-1306	142	14	dna	dna	NOUN
dti-1306	142	15	methylation	methylation	NOUN
dti-1306	142	16	and	and	CCONJ
dti-1306	142	17	covalent	covalent	NOUN
dti-1306	142	18	histone	histone	NOUN
dti-1306	142	19	modifi	modifi	NOUN
dti-1306	142	20	cations	cation	NOUN
dti-1306	142	21	)	)	PUNCT
dti-1306	142	22	that	that	PRON
dti-1306	142	23	are	be	AUX
dti-1306	142	24	heritable	heritable	ADJ
dti-1306	142	25	through	through	ADP
dti-1306	142	26	cell	cell	NOUN
dti-1306	142	27	division	division	NOUN
dti-1306	142	28	,	,	PUNCT
dti-1306	142	29	which	which	PRON
dti-1306	142	30	affect	affect	VERB
dti-1306	142	31	gene	gene	NOUN
dti-1306	142	32	expression	expression	NOUN
dti-1306	142	33	without	without	ADP
dti-1306	142	34	causing	cause	VERB
dti-1306	142	35	changes	change	NOUN
dti-1306	142	36	to	to	ADP
dti-1306	142	37	the	the	DET
dti-1306	142	38	dna	dna	PROPN
dti-1306	142	39	coding	code	VERB
dti-1306	142	40	sequence	sequence	NOUN
dti-1306	142	41	.	.	PUNCT
dti-1306	143	1	cancer	cancer	NOUN
dti-1306	143	2	cells	cell	NOUN
dti-1306	143	3	exhibit	exhibit	VERB
dti-1306	143	4	global	global	ADJ
dti-1306	143	5	hypomethylation	hypomethylation	NOUN
dti-1306	143	6	of	of	ADP
dti-1306	143	7	the	the	DET
dti-1306	143	8	genome	genome	NOUN
dti-1306	143	9	accompanied	accompany	VERB
dti-1306	143	10	by	by	ADP
dti-1306	143	11	region	region	NOUN
dti-1306	143	12	-	-	PUNCT
dti-1306	143	13	specifi	specifi	PROPN
dti-1306	143	14	c	c	PROPN
dti-1306	143	15	hypermethylation	hypermethylation	NOUN
dti-1306	143	16	events	event	NOUN
dti-1306	143	17	.	.	PUNCT
dti-1306	144	1	the	the	DET
dti-1306	144	2	hypomethylation	hypomethylation	NOUN
dti-1306	144	3	mainly	mainly	ADV
dti-1306	144	4	occurs	occur	VERB
dti-1306	144	5	in	in	ADP
dti-1306	144	6	the	the	DET
dti-1306	144	7	repetitive	repetitive	ADJ
dti-1306	144	8	sequences	sequence	NOUN
dti-1306	144	9	leading	lead	VERB
dti-1306	144	10	to	to	ADP
dti-1306	144	11	genomic	genomic	ADJ
dti-1306	144	12	instability	instability	NOUN
dti-1306	144	13	and	and	CCONJ
dti-1306	144	14	tumor	tumor	NOUN
dti-1306	144	15	formation	formation	NOUN
dti-1306	144	16	.	.	PUNCT
dti-1306	145	1	aberrant	aberrant	ADJ
dti-1306	145	2	hypermethylation	hypermethylation	NOUN
dti-1306	145	3	occurs	occur	VERB
dti-1306	145	4	at	at	ADP
dti-1306	145	5	cpg	cpg	PROPN
dti-1306	145	6	islands	island	NOUN
dti-1306	145	7	found	find	VERB
dti-1306	145	8	in	in	ADP
dti-1306	145	9	the	the	DET
dti-1306	145	10	promoter	promoter	NOUN
dti-1306	145	11	region	region	NOUN
dti-1306	145	12	of	of	ADP
dti-1306	145	13	genes	gene	NOUN
dti-1306	145	14	,	,	PUNCT
dti-1306	145	15	which	which	PRON
dti-1306	145	16	is	be	AUX
dti-1306	145	17	usually	usually	ADV
dti-1306	145	18	associated	associate	VERB
dti-1306	145	19	with	with	ADP
dti-1306	145	20	the	the	DET
dti-1306	145	21	transcriptional	transcriptional	ADJ
dti-1306	145	22	silencing	silencing	NOUN
dti-1306	145	23	of	of	ADP
dti-1306	145	24	that	that	DET
dti-1306	145	25	gene	gene	NOUN
dti-1306	145	26	(	(	PUNCT
dti-1306	145	27	baylin	baylin	PROPN
dti-1306	145	28	et	et	PROPN
dti-1306	145	29	al	al	PROPN
dti-1306	145	30	.	.	PROPN
dti-1306	145	31	2001	2001	NUM
dti-1306	145	32	)	)	PUNCT
dti-1306	145	33	.	.	PUNCT
dti-1306	146	1	dna	dna	PROPN
dti-1306	146	2	methylation	methylation	NOUN
dti-1306	146	3	changes	change	NOUN
dti-1306	146	4	(	(	PUNCT
dti-1306	146	5	palanichamy	palanichamy	NOUN
dti-1306	146	6	,	,	PUNCT
dti-1306	146	7	erkkinen	erkkinen	NOUN
dti-1306	146	8	and	and	CCONJ
dti-1306	146	9	chakravarti	chakravarti	NOUN
dti-1306	146	10	,	,	PUNCT
dti-1306	146	11	2006	2006	NUM
dti-1306	146	12	)	)	PUNCT
dti-1306	146	13	,	,	PUNCT
dti-1306	146	14	particularly	particularly	ADV
dti-1306	146	15	cpg	cpg	NOUN
dti-1306	146	16	island	island	NOUN
dti-1306	146	17	hypermethylation	hypermethylation	NOUN
dti-1306	146	18	is	be	AUX
dti-1306	146	19	frequent	frequent	ADJ
dti-1306	146	20	,	,	PUNCT
dti-1306	146	21	early	early	ADV
dti-1306	146	22	,	,	PUNCT
dti-1306	146	23	and	and	CCONJ
dti-1306	146	24	common	common	ADJ
dti-1306	146	25	event	event	NOUN
dti-1306	146	26	(	(	PUNCT
dti-1306	146	27	as	as	ADV
dti-1306	146	28	common	common	ADJ
dti-1306	146	29	as	as	ADP
dti-1306	146	30	mutations	mutation	NOUN
dti-1306	146	31	)	)	PUNCT
dti-1306	146	32	in	in	ADP
dti-1306	146	33	many	many	ADJ
dti-1306	146	34	types	type	NOUN
dti-1306	146	35	of	of	ADP
dti-1306	146	36	cancers	cancer	NOUN
dti-1306	146	37	leading	lead	VERB
dti-1306	146	38	to	to	ADP
dti-1306	146	39	the	the	DET
dti-1306	146	40	inactivation	inactivation	NOUN
dti-1306	146	41	of	of	ADP
dti-1306	146	42	tumor	tumor	NOUN
dti-1306	146	43	suppressor	suppressor	NOUN
dti-1306	146	44	genes	gene	NOUN
dti-1306	146	45	.	.	PUNCT
dti-1306	147	1	several	several	ADJ
dti-1306	147	2	genetic	genetic	ADJ
dti-1306	147	3	changes	change	NOUN
dti-1306	147	4	have	have	AUX
dti-1306	147	5	been	be	AUX
dti-1306	147	6	identifi	identifi	PROPN
dti-1306	147	7	ed	ed	NOUN
dti-1306	147	8	in	in	ADP
dti-1306	147	9	aas	aas	NOUN
dti-1306	147	10	and	and	CCONJ
dti-1306	147	11	gbms	gbms	PROPN
dti-1306	147	12	involving	involve	VERB
dti-1306	147	13	heterozygous	heterozygous	ADJ
dti-1306	147	14	deletion	deletion	NOUN
dti-1306	147	15	of	of	ADP
dti-1306	147	16	19q13	19q13	NUM
dti-1306	147	17	,	,	PUNCT
dti-1306	147	18	inactivation	inactivation	NOUN
dti-1306	147	19	/	/	SYM
dti-1306	147	20	deletion	deletion	NOUN
dti-1306	147	21	of	of	ADP
dti-1306	147	22	tumor	tumor	NOUN
dti-1306	147	23	suppressor	suppressor	NOUN
dti-1306	147	24	genes	gene	NOUN
dti-1306	147	25	namely	namely	ADV
dti-1306	147	26	p16ink4a	p16ink4a	PROPN
dti-1306	147	27	(	(	PUNCT
dti-1306	147	28	hegi	hegi	NOUN
dti-1306	147	29	et	et	PROPN
dti-1306	147	30	al	al	PROPN
dti-1306	147	31	.	.	PROPN
dti-1306	147	32	1997	1997	NUM
dti-1306	147	33	)	)	PUNCT
dti-1306	147	34	,	,	PUNCT
dti-1306	147	35	p14arf	p14arf	PROPN
dti-1306	147	36	(	(	PUNCT
dti-1306	147	37	ichimura	ichimura	PROPN
dti-1306	147	38	et	et	PROPN
dti-1306	147	39	al	al	PROPN
dti-1306	147	40	.	.	PROPN
dti-1306	147	41	2000	2000	NUM
dti-1306	147	42	)	)	PUNCT
dti-1306	147	43	,	,	PUNCT
dti-1306	147	44	rb1	rb1	PROPN
dti-1306	147	45	(	(	PUNCT
dti-1306	147	46	ichimura	ichimura	PROPN
dti-1306	147	47	et	et	PROPN
dti-1306	147	48	al	al	PROPN
dti-1306	147	49	.	.	PROPN
dti-1306	147	50	1996	1996	NUM
dti-1306	147	51	)	)	PUNCT
dti-1306	147	52	,	,	PUNCT
dti-1306	147	53	pten	pten	VERB
dti-1306	147	54	and	and	CCONJ
dti-1306	147	55	p53	p53	NOUN
dti-1306	147	56	gene	gene	NOUN
dti-1306	147	57	(	(	PUNCT
dti-1306	147	58	mashiyama	mashiyama	PROPN
dti-1306	147	59	et	et	PROPN
dti-1306	147	60	al	al	PROPN
dti-1306	147	61	.	.	PROPN
dti-1306	147	62	1991	1991	NUM
dti-1306	147	63	)	)	PUNCT
dti-1306	147	64	and	and	CCONJ
dti-1306	147	65	amplifi	amplifi	NOUN
dti-1306	147	66	cation	cation	NOUN
dti-1306	147	67	of	of	ADP
dti-1306	147	68	egfr	egfr	ADJ
dti-1306	147	69	gene	gene	NOUN
dti-1306	147	70	(	(	PUNCT
dti-1306	147	71	libermann	libermann	PROPN
dti-1306	147	72	et	et	PROPN
dti-1306	147	73	al	al	PROPN
dti-1306	147	74	.	.	PROPN
dti-1306	147	75	1985	1985	NUM
dti-1306	147	76	)	)	PUNCT
dti-1306	147	77	.	.	PUNCT
dti-1306	148	1	epigenetic	epigenetic	ADJ
dti-1306	148	2	research	research	NOUN
dti-1306	148	3	in	in	ADP
dti-1306	148	4	glioma	glioma	NOUN
dti-1306	148	5	pathogenesis	pathogenesis	NOUN
dti-1306	148	6	revealed	reveal	VERB
dti-1306	148	7	several	several	ADJ
dti-1306	148	8	epigenetic	epigenetic	ADJ
dti-1306	148	9	genes	gene	NOUN
dti-1306	148	10	silenced	silence	VERB
dti-1306	148	11	by	by	ADP
dti-1306	148	12	promoter	promoter	NOUN
dti-1306	148	13	cpg	cpg	PROPN
dti-1306	148	14	island	island	NOUN
dti-1306	148	15	hypermethylation	hypermethylation	NOUN
dti-1306	148	16	,	,	PUNCT
dti-1306	148	17	such	such	ADJ
dti-1306	148	18	as	as	ADP
dti-1306	148	19	,	,	PUNCT
dti-1306	148	20	cell	cell	NOUN
dti-1306	148	21	cycle	cycle	NOUN
dti-1306	148	22	regulatory	regulatory	ADJ
dti-1306	148	23	proteins	protein	NOUN
dti-1306	148	24	rb1	rb1	NOUN
dti-1306	148	25	(	(	PUNCT
dti-1306	148	26	nakamura	nakamura	PROPN
dti-1306	148	27	et	et	PROPN
dti-1306	148	28	al	al	PROPN
dti-1306	148	29	.	.	PROPN
dti-1306	148	30	1996	1996	NUM
dti-1306	148	31	)	)	PUNCT
dti-1306	148	32	,	,	PUNCT
dti-1306	148	33	p16ink4a	p16ink4a	PROPN
dti-1306	148	34	(	(	PUNCT
dti-1306	148	35	costello	costello	PROPN
dti-1306	148	36	et	et	PROPN
dti-1306	148	37	al	al	PROPN
dti-1306	148	38	.	.	PROPN
dti-1306	148	39	1996	1996	NUM
dti-1306	148	40	;	;	PUNCT
dti-1306	148	41	fueyo	fueyo	NOUN
dti-1306	148	42	et	et	PROPN
dti-1306	148	43	al	al	PROPN
dti-1306	148	44	.	.	PROPN
dti-1306	148	45	1996	1996	NUM
dti-1306	148	46	)	)	PUNCT
dti-1306	148	47	,	,	PUNCT
dti-1306	148	48	myelin	myelin	NOUN
dti-1306	148	49	related	relate	VERB
dti-1306	148	50	gene	gene	NOUN
dti-1306	148	51	emp3	emp3	NOUN
dti-1306	148	52	(	(	PUNCT
dti-1306	148	53	alaminos	alaminos	VERB
dti-1306	148	54	et	et	PROPN
dti-1306	148	55	al	al	PROPN
dti-1306	148	56	.	.	PROPN
dti-1306	148	57	2005	2005	NUM
dti-1306	148	58	)	)	PUNCT
dti-1306	148	59	,	,	PUNCT
dti-1306	148	60	and	and	CCONJ
dti-1306	148	61	matrix	matrix	NOUN
dti-1306	148	62	metalloproteinases	metalloproteinase	VERB
dti-1306	148	63	inhibitor	inhibitor	NOUN
dti-1306	148	64	timp3	timp3	NOUN
dti-1306	148	65	(	(	PUNCT
dti-1306	148	66	bachman	bachman	NOUN
dti-1306	148	67	et	et	PROPN
dti-1306	148	68	al	al	PROPN
dti-1306	148	69	.	.	PROPN
dti-1306	148	70	1999	1999	NUM
dti-1306	148	71	)	)	PUNCT
dti-1306	148	72	.	.	PUNCT
dti-1306	149	1	comprehensive	comprehensive	ADJ
dti-1306	149	2	whole	whole	ADJ
dti-1306	149	3	-	-	PUNCT
dti-1306	149	4	genome	genome	NOUN
dti-1306	149	5	microarray	microarray	NOUN
dti-1306	149	6	studies	study	NOUN
dti-1306	149	7	using	use	VERB
dti-1306	149	8	inhibitors	inhibitor	NOUN
dti-1306	149	9	of	of	ADP
dti-1306	149	10	epigenetic	epigenetic	ADJ
dti-1306	149	11	modifi	modifi	NOUN
dti-1306	149	12	cation	cation	NOUN
dti-1306	149	13	have	have	AUX
dti-1306	149	14	identified	identify	VERB
dti-1306	149	15	several	several	ADJ
dti-1306	149	16	genes	gene	NOUN
dti-1306	149	17	including	include	VERB
dti-1306	149	18	cst6	cst6	NOUN
dti-1306	149	19	(	(	PUNCT
dti-1306	149	20	putative	putative	ADJ
dti-1306	149	21	metastatic	metastatic	ADJ
dti-1306	149	22	suppressor	suppressor	NOUN
dti-1306	149	23	)	)	PUNCT
dti-1306	149	24	,	,	PUNCT
dti-1306	149	25	bik	bik	PROPN
dti-1306	149	26	(	(	PUNCT
dti-1306	149	27	apoptosis	apoptosis	NOUN
dti-1306	149	28	inducer	inducer	NOUN
dti-1306	149	29	)	)	PUNCT
dti-1306	149	30	,	,	PUNCT
dti-1306	149	31	tspyl5	tspyl5	NOUN
dti-1306	149	32	(	(	PUNCT
dti-1306	149	33	unknown	unknown	ADJ
dti-1306	149	34	function	function	NOUN
dti-1306	149	35	)	)	PUNCT
dti-1306	149	36	,	,	PUNCT
dti-1306	149	37	bex1	bex1	NOUN
dti-1306	149	38	,	,	PUNCT
dti-1306	149	39	and	and	CCONJ
dti-1306	149	40	bex2	bex2	NOUN
dti-1306	149	41	(	(	PUNCT
dti-1306	149	42	uncharacterized	uncharacterized	ADJ
dti-1306	149	43	function	function	NOUN
dti-1306	149	44	)	)	PUNCT
dti-1306	149	45	as	as	ADP
dti-1306	149	46	putative	putative	ADJ
dti-1306	149	47	tumor	tumor	NOUN
dti-1306	149	48	suppressors	suppressor	NOUN
dti-1306	149	49	that	that	PRON
dti-1306	149	50	are	be	AUX
dti-1306	149	51	frequently	frequently	ADV
dti-1306	149	52	methylated	methylate	VERB
dti-1306	149	53	in	in	ADP
dti-1306	149	54	primary	primary	ADJ
dti-1306	149	55	gliomas	glioma	NOUN
dti-1306	149	56	(	(	PUNCT
dti-1306	149	57	kim	kim	PROPN
dti-1306	149	58	et	et	PROPN
dti-1306	149	59	al	al	PROPN
dti-1306	149	60	.	.	PROPN
dti-1306	149	61	2006	2006	NUM
dti-1306	149	62	;	;	PUNCT
dti-1306	149	63	foltz	foltz	NOUN
dti-1306	149	64	et	et	PROPN
dti-1306	149	65	al	al	PROPN
dti-1306	149	66	.	.	PROPN
dti-1306	149	67	2006	2006	NUM
dti-1306	149	68	)	)	PUNCT
dti-1306	149	69	.	.	PUNCT
dti-1306	150	1	another	another	DET
dti-1306	150	2	genome	genome	NOUN
dti-1306	150	3	-	-	PUNCT
dti-1306	150	4	wide	wide	ADJ
dti-1306	150	5	study	study	NOUN
dti-1306	150	6	using	use	VERB
dti-1306	150	7	restriction	restriction	NOUN
dti-1306	150	8	landmark	landmark	NOUN
dti-1306	150	9	genomic	genomic	NOUN
dti-1306	150	10	scanning	scanning	NOUN
dti-1306	150	11	has	have	VERB
dti-1306	150	12	identifi	identifi	NOUN
dti-1306	150	13	ed	ed	NOUN
dti-1306	150	14	as	as	ADV
dti-1306	150	15	many	many	ADJ
dti-1306	150	16	as	as	ADP
dti-1306	150	17	1500	1500	NUM
dti-1306	150	18	cpg	cpg	NOUN
dti-1306	150	19	islands	island	NOUN
dti-1306	150	20	to	to	PART
dti-1306	150	21	be	be	AUX
dti-1306	150	22	aberrantly	aberrantly	ADV
dti-1306	150	23	methylated	methylate	VERB
dti-1306	150	24	in	in	ADP
dti-1306	150	25	low	low	ADJ
dti-1306	150	26	grade	grade	NOUN
dti-1306	150	27	gliomas	glioma	NOUN
dti-1306	150	28	(	(	PUNCT
dti-1306	150	29	costello	costello	PROPN
dti-1306	150	30	et	et	PROPN
dti-1306	150	31	al	al	PROPN
dti-1306	150	32	.	.	PROPN
dti-1306	150	33	2000	2000	NUM
dti-1306	150	34	)	)	PUNCT
dti-1306	150	35	.	.	PUNCT
dti-1306	151	1	these	these	DET
dti-1306	151	2	studies	study	NOUN
dti-1306	151	3	have	have	AUX
dti-1306	151	4	highlighted	highlight	VERB
dti-1306	151	5	a	a	DET
dti-1306	151	6	role	role	NOUN
dti-1306	151	7	for	for	ADP
dti-1306	151	8	dna	dna	PROPN
dti-1306	151	9	methylation	methylation	NOUN
dti-1306	151	10	in	in	ADP
dti-1306	151	11	gliomagenesis	gliomagenesis	NOUN
dti-1306	151	12	.	.	PUNCT
dti-1306	152	1	to	to	AUX
dti-1306	152	2	date	date	NOUN
dti-1306	152	3	very	very	ADV
dti-1306	152	4	few	few	ADJ
dti-1306	152	5	genetic	genetic	ADJ
dti-1306	152	6	assays	assay	NOUN
dti-1306	152	7	are	be	AUX
dti-1306	152	8	available	available	ADJ
dti-1306	152	9	to	to	PART
dti-1306	152	10	accurately	accurately	ADV
dti-1306	152	11	provide	provide	VERB
dti-1306	152	12	information	information	NOUN
dti-1306	152	13	regarding	regard	VERB
dti-1306	152	14	patient	patient	ADJ
dti-1306	152	15	prognosis	prognosis	NOUN
dti-1306	152	16	or	or	CCONJ
dti-1306	152	17	response	response	NOUN
dti-1306	152	18	to	to	ADP
dti-1306	152	19	therapy	therapy	NOUN
dti-1306	152	20	.	.	PUNCT
dti-1306	153	1	it	it	PRON
dti-1306	153	2	has	have	AUX
dti-1306	153	3	been	be	AUX
dti-1306	153	4	hypothesized	hypothesize	VERB
dti-1306	153	5	that	that	SCONJ
dti-1306	153	6	aberrant	aberrant	ADJ
dti-1306	153	7	dna	dna	PROPN
dti-1306	153	8	methylation	methylation	NOUN
dti-1306	153	9	plays	play	VERB
dti-1306	153	10	a	a	DET
dti-1306	153	11	key	key	ADJ
dti-1306	153	12	role	role	NOUN
dti-1306	153	13	in	in	ADP
dti-1306	153	14	tumor	tumor	NOUN
dti-1306	153	15	initiation	initiation	NOUN
dti-1306	153	16	.	.	PUNCT
dti-1306	154	1	therefore	therefore	ADV
dti-1306	154	2	identifying	identify	VERB
dti-1306	154	3	such	such	ADJ
dti-1306	154	4	modifi	modifi	NOUN
dti-1306	154	5	cations	cation	NOUN
dti-1306	154	6	helps	help	VERB
dti-1306	154	7	in	in	ADP
dti-1306	154	8	early	early	ADJ
dti-1306	154	9	detection	detection	NOUN
dti-1306	154	10	of	of	ADP
dti-1306	154	11	cancer	cancer	NOUN
dti-1306	154	12	,	,	PUNCT
dti-1306	154	13	and	and	CCONJ
dti-1306	154	14	might	might	AUX
dti-1306	154	15	also	also	ADV
dti-1306	154	16	provide	provide	VERB
dti-1306	154	17	information	information	NOUN
dti-1306	154	18	regarding	regard	VERB
dti-1306	154	19	the	the	DET
dti-1306	154	20	mechanisms	mechanism	NOUN
dti-1306	154	21	that	that	PRON
dti-1306	154	22	control	control	VERB
dti-1306	154	23	glioma	glioma	NOUN
dti-1306	154	24	progression	progression	NOUN
dti-1306	154	25	(	(	PUNCT
dti-1306	154	26	costello	costello	PROPN
dti-1306	154	27	,	,	PUNCT
dti-1306	154	28	2003	2003	NUM
dti-1306	154	29	)	)	PUNCT
dti-1306	154	30	.	.	PUNCT
dti-1306	155	1	in	in	ADP
dti-1306	155	2	addition	addition	NOUN
dti-1306	155	3	to	to	ADP
dti-1306	155	4	being	be	AUX
dti-1306	155	5	a	a	DET
dti-1306	155	6	diagnostic	diagnostic	ADJ
dti-1306	155	7	marker	marker	NOUN
dti-1306	155	8	,	,	PUNCT
dti-1306	155	9	dna	dna	PROPN
dti-1306	155	10	methylation	methylation	NOUN
dti-1306	155	11	can	can	AUX
dti-1306	155	12	also	also	ADV
dti-1306	155	13	serve	serve	VERB
dti-1306	155	14	as	as	ADP
dti-1306	155	15	an	an	DET
dti-1306	155	16	useful	useful	ADJ
dti-1306	155	17	prognostic	prognostic	ADJ
dti-1306	155	18	marker	marker	NOUN
dti-1306	155	19	as	as	SCONJ
dti-1306	155	20	shown	show	VERB
dti-1306	155	21	by	by	ADP
dti-1306	155	22	the	the	DET
dti-1306	155	23	methylation	methylation	NOUN
dti-1306	155	24	of	of	ADP
dti-1306	155	25	the	the	DET
dti-1306	155	26	dna	dna	PROPN
dti-1306	155	27	repair	repair	NOUN
dti-1306	155	28	gene	gene	NOUN
dti-1306	155	29	,	,	PUNCT
dti-1306	155	30	mgmt	mgmt	NOUN
dti-1306	155	31	,	,	PUNCT
dti-1306	155	32	in	in	ADP
dti-1306	155	33	gliomas	glioma	NOUN
dti-1306	155	34	.	.	PUNCT
dti-1306	156	1	epigenetic	epigenetic	ADJ
dti-1306	156	2	silencing	silencing	NOUN
dti-1306	156	3	of	of	ADP
dti-1306	156	4	the	the	DET
dti-1306	156	5	gene	gene	NOUN
dti-1306	156	6	(	(	PUNCT
dti-1306	156	7	involved	involve	VERB
dti-1306	156	8	in	in	ADP
dti-1306	156	9	the	the	DET
dti-1306	156	10	repair	repair	NOUN
dti-1306	156	11	of	of	ADP
dti-1306	156	12	dna	dna	PROPN
dti-1306	156	13	damaged	damage	VERB
dti-1306	156	14	by	by	ADP
dti-1306	156	15	alkylating	alkylate	VERB
dti-1306	156	16	agents	agent	NOUN
dti-1306	156	17	)	)	PUNCT
dti-1306	156	18	is	be	AUX
dti-1306	156	19	associated	associate	VERB
dti-1306	156	20	with	with	ADP
dti-1306	156	21	the	the	DET
dti-1306	156	22	increased	increase	VERB
dti-1306	156	23	survival	survival	NOUN
dti-1306	156	24	in	in	ADP
dti-1306	156	25	patients	patient	NOUN
dti-1306	156	26	treated	treat	VERB
dti-1306	156	27	with	with	ADP
dti-1306	156	28	alkylating	alkylate	VERB
dti-1306	156	29	drug	drug	NOUN
dti-1306	156	30	temozolomide	temozolomide	NOUN
dti-1306	156	31	(	(	PUNCT
dti-1306	156	32	esteller	esteller	NOUN
dti-1306	156	33	et	et	PROPN
dti-1306	156	34	al	al	PROPN
dti-1306	156	35	.	.	PROPN
dti-1306	156	36	2000	2000	NUM
dti-1306	156	37	;	;	PUNCT
dti-1306	156	38	komine	komine	PROPN
dti-1306	156	39	et	et	PROPN
dti-1306	156	40	al	al	PROPN
dti-1306	156	41	.	.	PROPN
dti-1306	156	42	2003	2003	NUM
dti-1306	156	43	)	)	PUNCT
dti-1306	156	44	.	.	PUNCT
dti-1306	157	1	current	current	ADJ
dti-1306	157	2	laboratory	laboratory	NOUN
dti-1306	157	3	studies	study	NOUN
dti-1306	157	4	are	be	AUX
dti-1306	157	5	aimed	aim	VERB
dti-1306	157	6	at	at	ADP
dti-1306	157	7	discovering	discover	VERB
dti-1306	157	8	novel	novel	ADJ
dti-1306	157	9	methylation	methylation	NOUN
dti-1306	157	10	markers	marker	NOUN
dti-1306	157	11	in	in	ADP
dti-1306	157	12	tumor	tumor	NOUN
dti-1306	157	13	tissue	tissue	NOUN
dti-1306	157	14	as	as	ADV
dti-1306	157	15	well	well	ADV
dti-1306	157	16	as	as	ADP
dti-1306	157	17	in	in	ADP
dti-1306	157	18	the	the	DET
dti-1306	157	19	patient	patient	NOUN
dti-1306	157	20	’s	’s	PART
dti-1306	157	21	body	body	NOUN
dti-1306	157	22	fl	fl	PROPN
dti-1306	157	23	uids	uids	PROPN
dti-1306	157	24	(	(	PUNCT
dti-1306	157	25	belinsky	belinsky	PROPN
dti-1306	157	26	et	et	PROPN
dti-1306	157	27	al	al	PROPN
dti-1306	157	28	.	.	PROPN
dti-1306	157	29	2006	2006	NUM
dti-1306	157	30	;	;	PUNCT
dti-1306	157	31	cairns	cairns	PROPN
dti-1306	157	32	et	et	PROPN
dti-1306	157	33	al	al	PROPN
dti-1306	157	34	.	.	PROPN
dti-1306	157	35	2001	2001	NUM
dti-1306	157	36	)	)	PUNCT
dti-1306	157	37	.	.	PUNCT
dti-1306	158	1	since	since	SCONJ
dti-1306	158	2	the	the	DET
dti-1306	158	3	primary	primary	ADJ
dti-1306	158	4	dna	dna	NOUN
dti-1306	158	5	sequence	sequence	NOUN
dti-1306	158	6	of	of	ADP
dti-1306	158	7	epigenetically	epigenetically	ADV
dti-1306	158	8	modifi	modifi	PROPN
dti-1306	158	9	ed	ed	PROPN
dti-1306	158	10	genes	gene	NOUN
dti-1306	158	11	remains	remain	VERB
dti-1306	158	12	intact	intact	ADJ
dti-1306	158	13	,	,	PUNCT
dti-1306	158	14	it	it	PRON
dti-1306	158	15	is	be	AUX
dti-1306	158	16	possible	possible	ADJ
dti-1306	158	17	to	to	PART
dti-1306	158	18	reactivate	reactivate	VERB
dti-1306	158	19	genes	gene	NOUN
dti-1306	158	20	using	use	VERB
dti-1306	158	21	inhibitors	inhibitor	NOUN
dti-1306	158	22	of	of	ADP
dti-1306	158	23	dna	dna	PROPN
dti-1306	158	24	methylation	methylation	NOUN
dti-1306	158	25	or	or	CCONJ
dti-1306	158	26	histone	histone	NOUN
dti-1306	158	27	modifi	modifi	NOUN
dti-1306	158	28	cations	cation	NOUN
dti-1306	158	29	(	(	PUNCT
dti-1306	158	30	daskalakis	daskalaki	NOUN
dti-1306	158	31	et	et	PROPN
dti-1306	158	32	al	al	PROPN
dti-1306	158	33	.	.	PROPN
dti-1306	158	34	2002	2002	NUM
dti-1306	158	35	;	;	PUNCT
dti-1306	158	36	plumb	plumb	PROPN
dti-1306	158	37	et	et	PROPN
dti-1306	158	38	al	al	PROPN
dti-1306	158	39	.	.	PROPN
dti-1306	158	40	2000	2000	NUM
dti-1306	158	41	)	)	PUNCT
dti-1306	158	42	.	.	PUNCT
dti-1306	159	1	clinical	clinical	ADJ
dti-1306	159	2	trials	trial	NOUN
dti-1306	159	3	using	use	VERB
dti-1306	159	4	dna	dna	PROPN
dti-1306	159	5	methylation	methylation	NOUN
dti-1306	159	6	and	and	CCONJ
dti-1306	159	7	histone	histone	NOUN
dti-1306	159	8	deacetylase	deacetylase	NOUN
dti-1306	159	9	inhibitors	inhibitor	NOUN
dti-1306	159	10	,	,	PUNCT
dti-1306	159	11	which	which	PRON
dti-1306	159	12	reactivate	reactivate	VERB
dti-1306	159	13	silenced	silence	VERB
dti-1306	159	14	genes	gene	NOUN
dti-1306	159	15	in	in	ADP
dti-1306	159	16	cancers	cancer	NOUN
dti-1306	159	17	,	,	PUNCT
dti-1306	159	18	are	be	AUX
dti-1306	159	19	in	in	ADP
dti-1306	159	20	various	various	ADJ
dti-1306	159	21	development	development	NOUN
dti-1306	159	22	stages	stage	NOUN
dti-1306	159	23	.	.	PUNCT
dti-1306	160	1	the	the	DET
dti-1306	160	2	dna	dna	PROPN
dti-1306	160	3	methyltransferase	methyltransferase	NOUN
dti-1306	160	4	inhibitors	inhibitor	NOUN
dti-1306	160	5	,	,	PUNCT
dti-1306	160	6	203	203	NUM
dti-1306	160	7	targeted	target	VERB
dti-1306	160	8	brain	brain	NOUN
dti-1306	160	9	tumor	tumor	NOUN
dti-1306	160	10	treatment	treatment	NOUN
dti-1306	160	11	drug	drug	NOUN
dti-1306	160	12	target	target	NOUN
dti-1306	160	13	insights	insight	NOUN
dti-1306	160	14	2007	2007	NUM
dti-1306	160	15	:	:	PUNCT
dti-1306	160	16	2	2	NUM
dti-1306	160	17	5	5	NUM
dti-1306	160	18	-	-	PUNCT
dti-1306	160	19	azacytidine	azacytidine	NOUN
dti-1306	160	20	(	(	PUNCT
dti-1306	160	21	vidaza	vidaza	NOUN
dti-1306	160	22	)	)	PUNCT
dti-1306	160	23	and	and	CCONJ
dti-1306	160	24	5	5	NUM
dti-1306	160	25	-	-	NUM
dti-1306	160	26	aza-2′-deoxycytidine	aza-2′-deoxycytidine	NOUN
dti-1306	160	27	(	(	PUNCT
dti-1306	160	28	decitabine	decitabine	NOUN
dti-1306	160	29	)	)	PUNCT
dti-1306	160	30	,	,	PUNCT
dti-1306	160	31	are	be	AUX
dti-1306	160	32	used	use	VERB
dti-1306	160	33	with	with	ADP
dti-1306	160	34	reasonable	reasonable	ADJ
dti-1306	160	35	success	success	NOUN
dti-1306	160	36	in	in	ADP
dti-1306	160	37	the	the	DET
dti-1306	160	38	treatment	treatment	NOUN
dti-1306	160	39	of	of	ADP
dti-1306	160	40	hematologic	hematologic	NOUN
dti-1306	160	41	malignancies	malignancy	NOUN
dti-1306	160	42	(	(	PUNCT
dti-1306	160	43	lubbert	lubbert	ADJ
dti-1306	160	44	,	,	PUNCT
dti-1306	160	45	2000	2000	NUM
dti-1306	160	46	)	)	PUNCT
dti-1306	160	47	,	,	PUNCT
dti-1306	160	48	but	but	CCONJ
dti-1306	160	49	have	have	VERB
dti-1306	160	50	limited	limit	VERB
dti-1306	160	51	success	success	NOUN
dti-1306	160	52	in	in	ADP
dti-1306	160	53	solid	solid	ADJ
dti-1306	160	54	tumors	tumor	NOUN
dti-1306	160	55	.	.	PUNCT
dti-1306	161	1	combination	combination	NOUN
dti-1306	161	2	of	of	ADP
dti-1306	161	3	hdac	hdac	NOUN
dti-1306	161	4	inhibitors	inhibitor	NOUN
dti-1306	161	5	with	with	ADP
dti-1306	161	6	dna	dna	PROPN
dti-1306	161	7	methyltransferase	methyltransferase	NOUN
dti-1306	161	8	inhibitors	inhibitor	NOUN
dti-1306	161	9	appear	appear	VERB
dti-1306	161	10	to	to	PART
dti-1306	161	11	synergistically	synergistically	ADV
dti-1306	161	12	induce	induce	VERB
dti-1306	161	13	the	the	DET
dti-1306	161	14	expression	expression	NOUN
dti-1306	161	15	of	of	ADP
dti-1306	161	16	silenced	silence	VERB
dti-1306	161	17	genes	gene	NOUN
dti-1306	161	18	(	(	PUNCT
dti-1306	161	19	cameron	cameron	PROPN
dti-1306	161	20	et	et	PROPN
dti-1306	161	21	al	al	PROPN
dti-1306	161	22	.	.	PROPN
dti-1306	161	23	1999	1999	NUM
dti-1306	161	24	)	)	PUNCT
dti-1306	161	25	.	.	PUNCT
dti-1306	162	1	however	however	ADV
dti-1306	162	2	,	,	PUNCT
dti-1306	162	3	these	these	DET
dti-1306	162	4	drugs	drug	NOUN
dti-1306	162	5	have	have	VERB
dti-1306	162	6	drawbacks	drawback	NOUN
dti-1306	162	7	such	such	ADJ
dti-1306	162	8	as	as	ADP
dti-1306	162	9	extreme	extreme	ADJ
dti-1306	162	10	instability	instability	NOUN
dti-1306	162	11	,	,	PUNCT
dti-1306	162	12	serious	serious	ADJ
dti-1306	162	13	side	side	NOUN
dti-1306	162	14	effects	effect	NOUN
dti-1306	162	15	,	,	PUNCT
dti-1306	162	16	and	and	CCONJ
dti-1306	162	17	sometimes	sometimes	ADV
dti-1306	162	18	these	these	DET
dti-1306	162	19	drugs	drug	NOUN
dti-1306	162	20	at	at	ADP
dti-1306	162	21	high	high	ADJ
dti-1306	162	22	doses	dose	NOUN
dti-1306	162	23	may	may	AUX
dti-1306	162	24	promote	promote	VERB
dti-1306	162	25	malignant	malignant	ADJ
dti-1306	162	26	transformation	transformation	NOUN
dti-1306	162	27	.	.	PUNCT
dti-1306	163	1	alternative	alternative	ADJ
dti-1306	163	2	approaches	approach	NOUN
dti-1306	163	3	include	include	VERB
dti-1306	163	4	the	the	DET
dti-1306	163	5	use	use	NOUN
dti-1306	163	6	of	of	ADP
dti-1306	163	7	sirna	sirna	PROPN
dti-1306	163	8	targeted	target	VERB
dti-1306	163	9	against	against	ADP
dti-1306	163	10	the	the	DET
dti-1306	163	11	dna	dna	PROPN
dti-1306	163	12	methyltransferase	methyltransferase	NOUN
dti-1306	163	13	enzyme	enzyme	NOUN
dti-1306	163	14	(	(	PUNCT
dti-1306	163	15	goffi	goffi	PROPN
dti-1306	163	16	n	n	NOUN
dti-1306	163	17	and	and	CCONJ
dti-1306	163	18	eisenhauer	eisenhauer	NOUN
dti-1306	163	19	,	,	PUNCT
dti-1306	163	20	2002	2002	NUM
dti-1306	163	21	)	)	PUNCT
dti-1306	163	22	and	and	CCONJ
dti-1306	163	23	developing	develop	VERB
dti-1306	163	24	stable	stable	ADJ
dti-1306	163	25	small	small	ADJ
dti-1306	163	26	molecule	molecule	NOUN
dti-1306	163	27	inhibitors	inhibitor	NOUN
dti-1306	163	28	that	that	PRON
dti-1306	163	29	can	can	AUX
dti-1306	163	30	overcome	overcome	VERB
dti-1306	163	31	the	the	DET
dti-1306	163	32	bbb	bbb	PROPN
dti-1306	163	33	.	.	PUNCT
dti-1306	164	1	small	small	ADJ
dti-1306	164	2	interfering	interfere	VERB
dti-1306	164	3	rna	rna	PROPN
dti-1306	164	4	(	(	PUNCT
dti-1306	164	5	sirna	sirna	PROPN
dti-1306	164	6	)	)	PUNCT
dti-1306	164	7	to	to	PART
dti-1306	164	8	target	target	VERB
dti-1306	164	9	brain	brain	NOUN
dti-1306	164	10	tumor	tumor	NOUN
dti-1306	164	11	gene(s	gene(s	PROPN
dti-1306	164	12	)	)	PUNCT
dti-1306	164	13	the	the	DET
dti-1306	164	14	sirna	sirna	PROPN
dti-1306	164	15	directs	direct	VERB
dti-1306	164	16	the	the	DET
dti-1306	164	17	targeted	targeted	ADJ
dti-1306	164	18	destruction	destruction	NOUN
dti-1306	164	19	of	of	ADP
dti-1306	164	20	mrna	mrna	PROPN
dti-1306	164	21	encoding	encode	VERB
dti-1306	164	22	a	a	DET
dti-1306	164	23	specific	specific	ADJ
dti-1306	164	24	protein	protein	NOUN
dti-1306	164	25	,	,	PUNCT
dti-1306	164	26	in	in	ADP
dti-1306	164	27	a	a	DET
dti-1306	164	28	process	process	NOUN
dti-1306	164	29	known	know	VERB
dti-1306	164	30	as	as	ADP
dti-1306	164	31	rna	rna	NOUN
dti-1306	164	32	interference	interference	NOUN
dti-1306	164	33	(	(	PUNCT
dti-1306	164	34	rnai	rnai	PROPN
dti-1306	164	35	)	)	PUNCT
dti-1306	164	36	.	.	PUNCT
dti-1306	165	1	this	this	DET
dti-1306	165	2	process	process	NOUN
dti-1306	165	3	stops	stop	VERB
dti-1306	165	4	translation	translation	NOUN
dti-1306	165	5	of	of	ADP
dti-1306	165	6	the	the	DET
dti-1306	165	7	targeted	target	VERB
dti-1306	165	8	mrna	mrna	NOUN
dti-1306	165	9	into	into	ADP
dti-1306	165	10	protein	protein	NOUN
dti-1306	165	11	,	,	PUNCT
dti-1306	165	12	effectively	effectively	ADV
dti-1306	165	13	silencing	silence	VERB
dti-1306	165	14	the	the	DET
dti-1306	165	15	gene	gene	NOUN
dti-1306	165	16	.	.	PUNCT
dti-1306	166	1	rnai	rnai	PROPN
dti-1306	166	2	is	be	AUX
dti-1306	166	3	a	a	DET
dti-1306	166	4	recent	recent	ADJ
dti-1306	166	5	discovery	discovery	NOUN
dti-1306	166	6	,	,	PUNCT
dti-1306	166	7	identified	identify	VERB
dti-1306	166	8	in	in	ADP
dti-1306	166	9	mammalian	mammalian	ADJ
dti-1306	166	10	cells	cell	NOUN
dti-1306	166	11	in	in	ADP
dti-1306	166	12	2001	2001	NUM
dti-1306	166	13	,	,	PUNCT
dti-1306	166	14	but	but	CCONJ
dti-1306	166	15	it	it	PRON
dti-1306	166	16	has	have	AUX
dti-1306	166	17	rapidly	rapidly	ADV
dti-1306	166	18	advanced	advance	VERB
dti-1306	166	19	into	into	ADP
dti-1306	166	20	practical	practical	ADJ
dti-1306	166	21	technique	technique	NOUN
dti-1306	166	22	,	,	PUNCT
dti-1306	166	23	and	and	CCONJ
dti-1306	166	24	is	be	AUX
dti-1306	166	25	being	be	AUX
dti-1306	166	26	used	use	VERB
dti-1306	166	27	increasingly	increasingly	ADV
dti-1306	166	28	to	to	PART
dti-1306	166	29	investigate	investigate	VERB
dti-1306	166	30	mammalian	mammalian	ADJ
dti-1306	166	31	gene	gene	NOUN
dti-1306	166	32	function	function	NOUN
dti-1306	166	33	.	.	PUNCT
dti-1306	167	1	tools	tool	NOUN
dti-1306	167	2	are	be	AUX
dti-1306	167	3	available	available	ADJ
dti-1306	167	4	to	to	PART
dti-1306	167	5	induce	induce	VERB
dti-1306	167	6	rnai	rnai	NOUN
dti-1306	167	7	in	in	ADP
dti-1306	167	8	cell	cell	NOUN
dti-1306	167	9	lines	line	NOUN
dti-1306	167	10	,	,	PUNCT
dti-1306	167	11	intact	intact	ADJ
dti-1306	167	12	tissue	tissue	NOUN
dti-1306	167	13	preparations	preparation	NOUN
dti-1306	167	14	,	,	PUNCT
dti-1306	167	15	and	and	CCONJ
dti-1306	167	16	even	even	ADV
dti-1306	167	17	in	in	ADP
dti-1306	167	18	in	in	ADP
dti-1306	167	19	vivo	vivo	NOUN
dti-1306	167	20	.	.	PUNCT
dti-1306	168	1	depending	depend	VERB
dti-1306	168	2	on	on	ADP
dti-1306	168	3	the	the	DET
dti-1306	168	4	method	method	NOUN
dti-1306	168	5	used	use	VERB
dti-1306	168	6	,	,	PUNCT
dti-1306	168	7	loss	loss	NOUN
dti-1306	168	8	of	of	ADP
dti-1306	168	9	gene	gene	NOUN
dti-1306	168	10	expression	expression	NOUN
dti-1306	168	11	may	may	AUX
dti-1306	168	12	be	be	AUX
dti-1306	168	13	transient	transient	ADJ
dti-1306	168	14	or	or	CCONJ
dti-1306	168	15	sustained	sustain	VERB
dti-1306	168	16	,	,	PUNCT
dti-1306	168	17	enabling	enable	VERB
dti-1306	168	18	a	a	DET
dti-1306	168	19	wide	wide	ADJ
dti-1306	168	20	range	range	NOUN
dti-1306	168	21	of	of	ADP
dti-1306	168	22	functions	function	NOUN
dti-1306	168	23	to	to	PART
dti-1306	168	24	be	be	AUX
dti-1306	168	25	investigated	investigate	VERB
dti-1306	168	26	.	.	PUNCT
dti-1306	169	1	the	the	DET
dti-1306	169	2	rnai	rnai	PROPN
dti-1306	169	3	is	be	AUX
dti-1306	169	4	a	a	DET
dti-1306	169	5	powerful	powerful	ADJ
dti-1306	169	6	technique	technique	NOUN
dti-1306	169	7	that	that	PRON
dti-1306	169	8	can	can	AUX
dti-1306	169	9	be	be	AUX
dti-1306	169	10	used	use	VERB
dti-1306	169	11	to	to	PART
dti-1306	169	12	produce	produce	VERB
dti-1306	169	13	targeted	target	VERB
dti-1306	169	14	knockout	knockout	NOUN
dti-1306	169	15	of	of	ADP
dti-1306	169	16	genes	gene	NOUN
dti-1306	169	17	in	in	ADP
dti-1306	169	18	mammalian	mammalian	ADJ
dti-1306	169	19	cells	cell	NOUN
dti-1306	169	20	(	(	PUNCT
dti-1306	169	21	gurney	gurney	NOUN
dti-1306	169	22	and	and	CCONJ
dti-1306	169	23	hunter	hunter	NOUN
dti-1306	169	24	,	,	PUNCT
dti-1306	169	25	2005	2005	NUM
dti-1306	169	26	)	)	PUNCT
dti-1306	169	27	.	.	PUNCT
dti-1306	170	1	its	its	PRON
dti-1306	170	2	applications	application	NOUN
dti-1306	170	3	potentially	potentially	ADV
dti-1306	170	4	include	include	VERB
dti-1306	170	5	identification	identification	NOUN
dti-1306	170	6	of	of	ADP
dti-1306	170	7	protein	protein	NOUN
dti-1306	170	8	function	function	NOUN
dti-1306	170	9	in	in	ADP
dti-1306	170	10	health	health	NOUN
dti-1306	170	11	and	and	CCONJ
dti-1306	170	12	disease	disease	NOUN
dti-1306	170	13	,	,	PUNCT
dti-1306	170	14	identification	identification	NOUN
dti-1306	170	15	of	of	ADP
dti-1306	170	16	novel	novel	ADJ
dti-1306	170	17	genes	gene	NOUN
dti-1306	170	18	,	,	PUNCT
dti-1306	170	19	and	and	CCONJ
dti-1306	170	20	drug	drug	NOUN
dti-1306	170	21	target	target	NOUN
dti-1306	170	22	validation	validation	NOUN
dti-1306	170	23	.	.	PUNCT
dti-1306	171	1	effective	effective	ADJ
dti-1306	171	2	rnai	rnai	PROPN
dti-1306	171	3	requires	require	VERB
dti-1306	171	4	an	an	DET
dti-1306	171	5	appropriate	appropriate	ADJ
dti-1306	171	6	sirna	sirna	PROPN
dti-1306	171	7	sequence	sequence	NOUN
dti-1306	171	8	to	to	PART
dti-1306	171	9	be	be	AUX
dti-1306	171	10	designed	design	VERB
dti-1306	171	11	and	and	CCONJ
dti-1306	171	12	an	an	DET
dti-1306	171	13	efficient	efficient	ADJ
dti-1306	171	14	method	method	NOUN
dti-1306	171	15	for	for	ADP
dti-1306	171	16	delivering	deliver	VERB
dti-1306	171	17	the	the	DET
dti-1306	171	18	sirna	sirna	PROPN
dti-1306	171	19	to	to	ADP
dti-1306	171	20	the	the	DET
dti-1306	171	21	cells	cell	NOUN
dti-1306	171	22	of	of	ADP
dti-1306	171	23	interest	interest	NOUN
dti-1306	171	24	.	.	PUNCT
dti-1306	172	1	since	since	SCONJ
dti-1306	172	2	not	not	PART
dti-1306	172	3	all	all	PRON
dti-1306	172	4	potential	potential	ADJ
dti-1306	172	5	sirna	sirna	PROPN
dti-1306	172	6	sequences	sequence	NOUN
dti-1306	172	7	are	be	AUX
dti-1306	172	8	effective	effective	ADJ
dti-1306	172	9	,	,	PUNCT
dti-1306	172	10	it	it	PRON
dti-1306	172	11	is	be	AUX
dti-1306	172	12	important	important	ADJ
dti-1306	172	13	to	to	PART
dti-1306	172	14	verify	verify	VERB
dti-1306	172	15	the	the	DET
dti-1306	172	16	loss	loss	NOUN
dti-1306	172	17	of	of	ADP
dti-1306	172	18	gene	gene	NOUN
dti-1306	172	19	expression	expression	NOUN
dti-1306	172	20	by	by	ADP
dti-1306	172	21	measuring	measure	VERB
dti-1306	172	22	the	the	DET
dti-1306	172	23	level	level	NOUN
dti-1306	172	24	of	of	ADP
dti-1306	172	25	protein	protein	NOUN
dti-1306	172	26	remaining	remain	VERB
dti-1306	172	27	.	.	PUNCT
dti-1306	173	1	limitations	limitation	NOUN
dti-1306	173	2	for	for	ADP
dti-1306	173	3	delivering	deliver	VERB
dti-1306	173	4	sirna	sirna	PROPN
dti-1306	173	5	are	be	AUX
dti-1306	173	6	one	one	NUM
dti-1306	173	7	of	of	ADP
dti-1306	173	8	the	the	DET
dti-1306	173	9	main	main	ADJ
dti-1306	173	10	obstacles	obstacle	NOUN
dti-1306	173	11	to	to	PART
dti-1306	173	12	produce	produce	VERB
dti-1306	173	13	efficient	efficient	ADJ
dti-1306	173	14	rnai	rnai	NOUN
dti-1306	173	15	,	,	PUNCT
dti-1306	173	16	especially	especially	ADV
dti-1306	173	17	in	in	ADP
dti-1306	173	18	intact	intact	ADJ
dti-1306	173	19	tissue	tissue	NOUN
dti-1306	173	20	preparations	preparation	NOUN
dti-1306	173	21	.	.	PUNCT
dti-1306	174	1	a	a	DET
dti-1306	174	2	successful	successful	ADJ
dti-1306	174	3	in	in	ADP
dti-1306	174	4	vitro	vitro	X
dti-1306	174	5	method	method	NOUN
dti-1306	174	6	for	for	ADP
dti-1306	174	7	targeted	target	VERB
dti-1306	174	8	rnai	rnai	NOUN
dti-1306	174	9	against	against	ADP
dti-1306	174	10	the	the	DET
dti-1306	174	11	task-1	task-1	NUM
dti-1306	174	12	potassium	potassium	NOUN
dti-1306	174	13	channel	channel	NOUN
dti-1306	174	14	gene	gene	NOUN
dti-1306	174	15	(	(	PUNCT
dti-1306	174	16	gurney	gurney	NOUN
dti-1306	174	17	and	and	CCONJ
dti-1306	174	18	hunter	hunter	NOUN
dti-1306	174	19	,	,	PUNCT
dti-1306	174	20	2005	2005	NUM
dti-1306	174	21	)	)	PUNCT
dti-1306	174	22	was	be	AUX
dti-1306	174	23	described	describe	VERB
dti-1306	174	24	.	.	PUNCT
dti-1306	175	1	increasing	increase	VERB
dti-1306	175	2	evidence	evidence	NOUN
dti-1306	175	3	show	show	VERB
dti-1306	175	4	that	that	SCONJ
dti-1306	175	5	microrna	microrna	PROPN
dti-1306	175	6	(	(	PUNCT
dti-1306	175	7	mirna	mirna	PROPN
dti-1306	175	8	)	)	PUNCT
dti-1306	175	9	represent	represent	VERB
dti-1306	175	10	a	a	DET
dti-1306	175	11	new	new	ADJ
dti-1306	175	12	class	class	NOUN
dti-1306	175	13	of	of	ADP
dti-1306	175	14	genes	gene	NOUN
dti-1306	175	15	involved	involve	VERB
dti-1306	175	16	in	in	ADP
dti-1306	175	17	oncogenesis	oncogenesis	NOUN
dti-1306	175	18	(	(	PUNCT
dti-1306	175	19	ciafre	ciafre	NOUN
dti-1306	175	20	et	et	PROPN
dti-1306	175	21	al	al	PROPN
dti-1306	175	22	.	.	PROPN
dti-1306	175	23	2005	2005	NUM
dti-1306	175	24	)	)	PUNCT
dti-1306	175	25	.	.	PUNCT
dti-1306	176	1	mirnas	mirna	NOUN
dti-1306	176	2	as	as	ADP
dti-1306	176	3	druggable	druggable	ADJ
dti-1306	176	4	targets	target	NOUN
dti-1306	176	5	the	the	DET
dti-1306	176	6	mirnas	mirna	NOUN
dti-1306	176	7	are	be	AUX
dti-1306	176	8	non	non	ADJ
dti-1306	176	9	-	-	ADJ
dti-1306	176	10	coding	coding	ADJ
dti-1306	176	11	,	,	PUNCT
dti-1306	176	12	double	double	ADJ
dti-1306	176	13	stranded	strand	VERB
dti-1306	176	14	rna	rna	NOUN
dti-1306	176	15	molecules	molecule	NOUN
dti-1306	176	16	with	with	ADP
dti-1306	176	17	an	an	DET
dti-1306	176	18	average	average	ADJ
dti-1306	176	19	size	size	NOUN
dti-1306	176	20	of	of	ADP
dti-1306	176	21	22	22	NUM
dti-1306	176	22	bp	bp	NOUN
dti-1306	176	23	,	,	PUNCT
dti-1306	176	24	and	and	CCONJ
dti-1306	176	25	serve	serve	VERB
dti-1306	176	26	as	as	ADP
dti-1306	176	27	posttranscriptional	posttranscriptional	ADJ
dti-1306	176	28	regulators	regulator	NOUN
dti-1306	176	29	of	of	ADP
dti-1306	176	30	gene	gene	NOUN
dti-1306	176	31	expression	expression	NOUN
dti-1306	176	32	in	in	ADP
dti-1306	176	33	higher	high	ADJ
dti-1306	176	34	eukaryotes	eukaryote	NOUN
dti-1306	176	35	.	.	PUNCT
dti-1306	177	1	the	the	DET
dti-1306	177	2	mirnas	mirna	NOUN
dti-1306	177	3	play	play	VERB
dti-1306	177	4	an	an	DET
dti-1306	177	5	important	important	ADJ
dti-1306	177	6	role	role	NOUN
dti-1306	177	7	in	in	ADP
dti-1306	177	8	development	development	NOUN
dti-1306	177	9	and	and	CCONJ
dti-1306	177	10	other	other	ADJ
dti-1306	177	11	cellular	cellular	ADJ
dti-1306	177	12	processes	process	NOUN
dti-1306	177	13	by	by	ADP
dti-1306	177	14	hybridizing	hybridize	VERB
dti-1306	177	15	to	to	ADP
dti-1306	177	16	complementary	complementary	ADJ
dti-1306	177	17	target	target	NOUN
dti-1306	177	18	mrna	mrna	NOUN
dti-1306	177	19	transcripts	transcript	NOUN
dti-1306	177	20	and	and	CCONJ
dti-1306	177	21	destabilizing	destabilize	VERB
dti-1306	177	22	the	the	DET
dti-1306	177	23	latter	latter	ADJ
dti-1306	177	24	by	by	ADP
dti-1306	177	25	preventing	prevent	VERB
dti-1306	177	26	their	their	PRON
dti-1306	177	27	translation	translation	NOUN
dti-1306	177	28	(	(	PUNCT
dti-1306	177	29	ambros	ambros	PROPN
dti-1306	177	30	,	,	PUNCT
dti-1306	177	31	2003	2003	NUM
dti-1306	177	32	;	;	PUNCT
dti-1306	177	33	bartel	bartel	NOUN
dti-1306	177	34	and	and	CCONJ
dti-1306	177	35	bartel	bartel	PROPN
dti-1306	177	36	,	,	PUNCT
dti-1306	177	37	2003	2003	NUM
dti-1306	177	38	;	;	PUNCT
dti-1306	177	39	bartel	bartel	PROPN
dti-1306	177	40	,	,	PUNCT
dti-1306	177	41	2004	2004	NUM
dti-1306	177	42	)	)	PUNCT
dti-1306	177	43	.	.	PUNCT
dti-1306	178	1	although	although	SCONJ
dti-1306	178	2	a	a	DET
dti-1306	178	3	few	few	ADJ
dti-1306	178	4	hundred	hundred	NUM
dti-1306	178	5	mirnas	mirna	NOUN
dti-1306	178	6	have	have	AUX
dti-1306	178	7	been	be	AUX
dti-1306	178	8	discovered	discover	VERB
dti-1306	178	9	in	in	ADP
dti-1306	178	10	a	a	DET
dti-1306	178	11	variety	variety	NOUN
dti-1306	178	12	of	of	ADP
dti-1306	178	13	organisms	organism	NOUN
dti-1306	178	14	,	,	PUNCT
dti-1306	178	15	little	little	ADJ
dti-1306	178	16	is	be	AUX
dti-1306	178	17	known	know	VERB
dti-1306	178	18	about	about	ADP
dti-1306	178	19	their	their	PRON
dti-1306	178	20	cellular	cellular	ADJ
dti-1306	178	21	functions	function	NOUN
dti-1306	178	22	.	.	PUNCT
dti-1306	179	1	they	they	PRON
dti-1306	179	2	have	have	AUX
dti-1306	179	3	been	be	AUX
dti-1306	179	4	implicated	implicate	VERB
dti-1306	179	5	,	,	PUNCT
dti-1306	179	6	among	among	ADP
dti-1306	179	7	others	other	NOUN
dti-1306	179	8	,	,	PUNCT
dti-1306	179	9	in	in	ADP
dti-1306	179	10	regulation	regulation	NOUN
dti-1306	179	11	of	of	ADP
dti-1306	179	12	developmental	developmental	ADJ
dti-1306	179	13	timing	timing	NOUN
dti-1306	179	14	and	and	CCONJ
dti-1306	179	15	pattern	pattern	NOUN
dti-1306	179	16	formation	formation	NOUN
dti-1306	179	17	,	,	PUNCT
dti-1306	179	18	restriction	restriction	NOUN
dti-1306	179	19	of	of	ADP
dti-1306	179	20	differentiation	differentiation	NOUN
dti-1306	179	21	potential	potential	NOUN
dti-1306	179	22	,	,	PUNCT
dti-1306	179	23	regulation	regulation	NOUN
dti-1306	179	24	of	of	ADP
dti-1306	179	25	insulin	insulin	NOUN
dti-1306	179	26	secretion	secretion	NOUN
dti-1306	179	27	,	,	PUNCT
dti-1306	179	28	resistance	resistance	NOUN
dti-1306	179	29	to	to	ADP
dti-1306	179	30	viral	viral	ADJ
dti-1306	179	31	infection	infection	NOUN
dti-1306	179	32	,	,	PUNCT
dti-1306	179	33	and	and	CCONJ
dti-1306	179	34	in	in	ADP
dti-1306	179	35	genomic	genomic	ADJ
dti-1306	179	36	rearrangements	rearrangement	NOUN
dti-1306	179	37	associated	associate	VERB
dti-1306	179	38	with	with	ADP
dti-1306	179	39	carcinogenesis	carcinogenesis	NOUN
dti-1306	179	40	or	or	CCONJ
dti-1306	179	41	other	other	ADJ
dti-1306	179	42	genetic	genetic	ADJ
dti-1306	179	43	disorders	disorder	NOUN
dti-1306	179	44	,	,	PUNCT
dti-1306	179	45	such	such	ADJ
dti-1306	179	46	as	as	ADP
dti-1306	179	47	the	the	DET
dti-1306	179	48	fragile	fragile	ADJ
dti-1306	179	49	x	x	NOUN
dti-1306	179	50	syndrome	syndrome	NOUN
dti-1306	179	51	.	.	PUNCT
dti-1306	180	1	recent	recent	ADJ
dti-1306	180	2	evidence	evidence	NOUN
dti-1306	180	3	suggests	suggest	VERB
dti-1306	180	4	that	that	SCONJ
dti-1306	180	5	the	the	DET
dti-1306	180	6	number	number	NOUN
dti-1306	180	7	of	of	ADP
dti-1306	180	8	unique	unique	ADJ
dti-1306	180	9	mirna	mirna	NOUN
dti-1306	180	10	genes	gene	NOUN
dti-1306	180	11	in	in	ADP
dti-1306	180	12	human	human	ADJ
dti-1306	180	13	ranges	range	NOUN
dti-1306	180	14	from	from	ADP
dti-1306	180	15	1000	1000	NUM
dti-1306	180	16	to	to	ADP
dti-1306	180	17	20,000	20,000	NUM
dti-1306	180	18	.	.	PUNCT
dti-1306	181	1	it	it	PRON
dti-1306	181	2	is	be	AUX
dti-1306	181	3	estimated	estimate	VERB
dti-1306	181	4	that	that	SCONJ
dti-1306	181	5	20%–30	20%–30	NUM
dti-1306	181	6	%	%	NOUN
dti-1306	181	7	of	of	ADP
dti-1306	181	8	all	all	DET
dti-1306	181	9	human	human	ADJ
dti-1306	181	10	mrna	mrna	PROPN
dti-1306	181	11	genes	gene	NOUN
dti-1306	181	12	are	be	AUX
dti-1306	181	13	mirna	mirna	NOUN
dti-1306	181	14	targets	target	NOUN
dti-1306	181	15	,	,	PUNCT
dti-1306	181	16	and	and	CCONJ
dti-1306	181	17	hence	hence	ADV
dti-1306	181	18	special	special	ADJ
dti-1306	181	19	attention	attention	NOUN
dti-1306	181	20	has	have	AUX
dti-1306	181	21	been	be	AUX
dti-1306	181	22	given	give	VERB
dti-1306	181	23	to	to	ADP
dti-1306	181	24	mirnas	mirna	NOUN
dti-1306	181	25	as	as	ADP
dti-1306	181	26	candidate	candidate	NOUN
dti-1306	181	27	drug	drug	NOUN
dti-1306	181	28	targets	target	NOUN
dti-1306	181	29	in	in	ADP
dti-1306	181	30	brain	brain	NOUN
dti-1306	181	31	tumor	tumor	NOUN
dti-1306	181	32	.	.	PUNCT
dti-1306	182	1	several	several	ADJ
dti-1306	182	2	recent	recent	ADJ
dti-1306	182	3	reviews	review	NOUN
dti-1306	182	4	and	and	CCONJ
dti-1306	182	5	research	research	NOUN
dti-1306	182	6	articles	article	NOUN
dti-1306	182	7	have	have	AUX
dti-1306	182	8	illustrated	illustrate	VERB
dti-1306	182	9	the	the	DET
dti-1306	182	10	involvement	involvement	NOUN
dti-1306	182	11	of	of	ADP
dti-1306	182	12	mirnas	mirna	NOUN
dti-1306	182	13	in	in	ADP
dti-1306	182	14	cancer	cancer	NOUN
dti-1306	182	15	(	(	PUNCT
dti-1306	182	16	calin	calin	PROPN
dti-1306	182	17	and	and	CCONJ
dti-1306	182	18	croce	croce	PROPN
dti-1306	182	19	,	,	PUNCT
dti-1306	182	20	2006a	2006a	NUM
dti-1306	182	21	,	,	PUNCT
dti-1306	182	22	2006b	2006b	NUM
dti-1306	182	23	;	;	PUNCT
dti-1306	182	24	jannot	jannot	ADV
dti-1306	182	25	and	and	CCONJ
dti-1306	182	26	simard	simard	NOUN
dti-1306	182	27	,	,	PUNCT
dti-1306	182	28	2006	2006	NUM
dti-1306	182	29	;	;	PUNCT
dti-1306	182	30	kent	kent	NOUN
dti-1306	182	31	and	and	CCONJ
dti-1306	182	32	mendell	mendell	PROPN
dti-1306	182	33	,	,	PUNCT
dti-1306	182	34	2006	2006	NUM
dti-1306	182	35	;	;	PUNCT
dti-1306	182	36	jovanovic	jovanovic	PROPN
dti-1306	182	37	and	and	CCONJ
dti-1306	182	38	hengartner	hengartner	NOUN
dti-1306	182	39	,	,	PUNCT
dti-1306	182	40	2006	2006	NUM
dti-1306	182	41	;	;	PUNCT
dti-1306	182	42	dalmay	dalmay	PROPN
dti-1306	182	43	and	and	CCONJ
dti-1306	182	44	edwards	edwards	PROPN
dti-1306	182	45	,	,	PUNCT
dti-1306	182	46	2006	2006	NUM
dti-1306	182	47	;	;	PUNCT
dti-1306	182	48	hutvagner	hutvagner	NOUN
dti-1306	182	49	,	,	PUNCT
dti-1306	182	50	2006	2006	NUM
dti-1306	182	51	;	;	PUNCT
dti-1306	182	52	osada	osada	NOUN
dti-1306	182	53	and	and	CCONJ
dti-1306	182	54	takahashi	takahashi	PROPN
dti-1306	182	55	,	,	PUNCT
dti-1306	182	56	2006	2006	NUM
dti-1306	182	57	;	;	PUNCT
dti-1306	182	58	zhang	zhang	PROPN
dti-1306	182	59	and	and	CCONJ
dti-1306	182	60	coukos	coukos	PROPN
dti-1306	182	61	,	,	PUNCT
dti-1306	182	62	2006	2006	NUM
dti-1306	182	63	)	)	PUNCT
dti-1306	182	64	.	.	PUNCT
dti-1306	183	1	therefore	therefore	ADV
dti-1306	183	2	,	,	PUNCT
dti-1306	183	3	we	we	PRON
dti-1306	183	4	will	will	AUX
dti-1306	183	5	restrict	restrict	VERB
dti-1306	183	6	this	this	DET
dti-1306	183	7	section	section	NOUN
dti-1306	183	8	to	to	ADP
dti-1306	183	9	the	the	DET
dti-1306	183	10	general	general	ADJ
dti-1306	183	11	concepts	concept	NOUN
dti-1306	183	12	.	.	PUNCT
dti-1306	184	1	in	in	ADP
dti-1306	184	2	a	a	DET
dti-1306	184	3	recent	recent	ADJ
dti-1306	184	4	study	study	NOUN
dti-1306	184	5	the	the	DET
dti-1306	184	6	mirna	mirna	PROPN
dti-1306	184	7	expression	expression	NOUN
dti-1306	184	8	levels	level	NOUN
dti-1306	184	9	in	in	ADP
dti-1306	184	10	gbm	gbm	PROPN
dti-1306	184	11	was	be	AUX
dti-1306	184	12	investigated	investigate	VERB
dti-1306	184	13	(	(	PUNCT
dti-1306	184	14	ciafre	ciafre	NOUN
dti-1306	184	15	et	et	PROPN
dti-1306	184	16	al	al	PROPN
dti-1306	184	17	.	.	PROPN
dti-1306	184	18	2005	2005	NUM
dti-1306	184	19	;	;	PUNCT
dti-1306	184	20	chan	chan	PROPN
dti-1306	184	21	,	,	PUNCT
dti-1306	184	22	krichevsky	krichevsky	PROPN
dti-1306	184	23	and	and	CCONJ
dti-1306	184	24	kosik	kosik	PROPN
dti-1306	184	25	,	,	PUNCT
dti-1306	184	26	2005	2005	NUM
dti-1306	184	27	)	)	PUNCT
dti-1306	184	28	.	.	PUNCT
dti-1306	185	1	the	the	DET
dti-1306	185	2	analysis	analysis	NOUN
dti-1306	185	3	of	of	ADP
dti-1306	185	4	both	both	DET
dti-1306	185	5	glioblastoma	glioblastoma	NOUN
dti-1306	185	6	tissues	tissue	NOUN
dti-1306	185	7	and	and	CCONJ
dti-1306	185	8	glioblastoma	glioblastoma	NOUN
dti-1306	185	9	cell	cell	NOUN
dti-1306	185	10	lines	line	NOUN
dti-1306	185	11	showed	show	VERB
dti-1306	185	12	a	a	DET
dti-1306	185	13	signifi	signifi	NOUN
dti-1306	185	14	cantly	cantly	ADV
dti-1306	185	15	altered	alter	VERB
dti-1306	185	16	mirna	mirna	NOUN
dti-1306	185	17	expression	expression	NOUN
dti-1306	185	18	.	.	PUNCT
dti-1306	186	1	the	the	DET
dti-1306	186	2	most	most	ADV
dti-1306	186	3	interesting	interesting	ADJ
dti-1306	186	4	mirna	mirna	NOUN
dti-1306	186	5	is	be	AUX
dti-1306	186	6	mir-21	mir-21	PROPN
dti-1306	186	7	,	,	PUNCT
dti-1306	186	8	which	which	PRON
dti-1306	186	9	is	be	AUX
dti-1306	186	10	signifi	signifi	NOUN
dti-1306	186	11	cantly	cantly	ADV
dti-1306	186	12	upregulated	upregulate	VERB
dti-1306	186	13	in	in	ADP
dti-1306	186	14	glioblastoma	glioblastoma	NOUN
dti-1306	186	15	.	.	PUNCT
dti-1306	187	1	in	in	ADP
dti-1306	187	2	another	another	DET
dti-1306	187	3	study	study	NOUN
dti-1306	187	4	,	,	PUNCT
dti-1306	187	5	knockdown	knockdown	NOUN
dti-1306	187	6	of	of	ADP
dti-1306	187	7	mirna-21	mirna-21	PROPN
dti-1306	187	8	in	in	ADP
dti-1306	187	9	cultured	cultured	ADJ
dti-1306	187	10	glioblastoma	glioblastoma	NOUN
dti-1306	187	11	cells	cell	NOUN
dti-1306	187	12	triggers	trigger	VERB
dti-1306	187	13	activation	activation	NOUN
dti-1306	187	14	of	of	ADP
dti-1306	187	15	caspases	caspase	NOUN
dti-1306	187	16	that	that	PRON
dti-1306	187	17	leads	lead	VERB
dti-1306	187	18	to	to	ADP
dti-1306	187	19	increased	increase	VERB
dti-1306	187	20	apoptotic	apoptotic	ADJ
dti-1306	187	21	cell	cell	NOUN
dti-1306	187	22	death	death	NOUN
dti-1306	187	23	(	(	PUNCT
dti-1306	187	24	chan	chan	PROPN
dti-1306	187	25	,	,	PUNCT
dti-1306	187	26	krichevsky	krichevsky	PROPN
dti-1306	187	27	and	and	CCONJ
dti-1306	187	28	kosik	kosik	PROPN
dti-1306	187	29	,	,	PUNCT
dti-1306	187	30	2005	2005	NUM
dti-1306	187	31	)	)	PUNCT
dti-1306	187	32	.	.	PUNCT
dti-1306	188	1	these	these	DET
dti-1306	188	2	data	datum	NOUN
dti-1306	188	3	suggest	suggest	VERB
dti-1306	188	4	that	that	SCONJ
dti-1306	188	5	aberrantly	aberrantly	ADV
dti-1306	188	6	expressed	express	VERB
dti-1306	188	7	mir-21	mir-21	PROPN
dti-1306	188	8	may	may	AUX
dti-1306	188	9	contribute	contribute	VERB
dti-1306	188	10	to	to	ADP
dti-1306	188	11	the	the	DET
dti-1306	188	12	malignant	malignant	ADJ
dti-1306	188	13	phenotype	phenotype	NOUN
dti-1306	188	14	by	by	ADP
dti-1306	188	15	blocking	block	VERB
dti-1306	188	16	expression	expression	NOUN
dti-1306	188	17	204	204	NUM
dti-1306	188	18	ningaraj	ningaraj	ADJ
dti-1306	188	19	et	et	PROPN
dti-1306	188	20	al	al	PROPN
dti-1306	188	21	drug	drug	PROPN
dti-1306	188	22	target	target	NOUN
dti-1306	188	23	insights	insight	NOUN
dti-1306	188	24	2007	2007	NUM
dti-1306	188	25	:	:	PUNCT
dti-1306	188	26	2	2	NUM
dti-1306	188	27	of	of	ADP
dti-1306	188	28	critical	critical	ADJ
dti-1306	188	29	apoptosis	apoptosis	NOUN
dti-1306	188	30	-	-	PUNCT
dti-1306	188	31	related	relate	VERB
dti-1306	188	32	genes	gene	NOUN
dti-1306	188	33	.	.	PUNCT
dti-1306	189	1	a	a	DET
dti-1306	189	2	set	set	NOUN
dti-1306	189	3	of	of	ADP
dti-1306	189	4	brain	brain	NOUN
dti-1306	189	5	-	-	PUNCT
dti-1306	189	6	enriched	enrich	VERB
dti-1306	189	7	mirnas	mirna	NOUN
dti-1306	189	8	,	,	PUNCT
dti-1306	189	9	mir-128	mir-128	NOUN
dti-1306	189	10	,	,	PUNCT
dti-1306	189	11	mir-181a	mir-181a	NUM
dti-1306	189	12	,	,	PUNCT
dti-1306	189	13	mir-181b	mir-181b	X
dti-1306	189	14	,	,	PUNCT
dti-1306	189	15	and	and	CCONJ
dti-1306	189	16	mir-181c	mir-181c	NOUN
dti-1306	189	17	,	,	PUNCT
dti-1306	189	18	are	be	AUX
dti-1306	189	19	down	down	ADV
dti-1306	189	20	-	-	PUNCT
dti-1306	189	21	regulated	regulate	VERB
dti-1306	189	22	in	in	ADP
dti-1306	189	23	glioblastoma	glioblastoma	NOUN
dti-1306	189	24	is	be	AUX
dti-1306	189	25	also	also	ADV
dti-1306	189	26	discovered	discover	VERB
dti-1306	189	27	(	(	PUNCT
dti-1306	189	28	ciafre	ciafre	NOUN
dti-1306	189	29	et	et	PROPN
dti-1306	189	30	al	al	PROPN
dti-1306	189	31	.	.	PROPN
dti-1306	189	32	2005	2005	NUM
dti-1306	189	33	;	;	PUNCT
dti-1306	189	34	o’driscoll	o’driscoll	NOUN
dti-1306	189	35	,	,	PUNCT
dti-1306	189	36	2006	2006	NUM
dti-1306	189	37	)	)	PUNCT
dti-1306	189	38	.	.	PUNCT
dti-1306	190	1	one	one	NUM
dti-1306	190	2	of	of	ADP
dti-1306	190	3	the	the	DET
dti-1306	190	4	early	early	ADJ
dti-1306	190	5	works	work	NOUN
dti-1306	190	6	that	that	PRON
dti-1306	190	7	demonstrates	demonstrate	VERB
dti-1306	190	8	mirnas	mirna	NOUN
dti-1306	190	9	as	as	ADP
dti-1306	190	10	potential	potential	ADJ
dti-1306	190	11	candidate	candidate	NOUN
dti-1306	190	12	drug	drug	NOUN
dti-1306	190	13	target	target	NOUN
dti-1306	190	14	was	be	AUX
dti-1306	190	15	performed	perform	VERB
dti-1306	190	16	by	by	ADP
dti-1306	190	17	obstructing	obstruct	VERB
dti-1306	190	18	the	the	DET
dti-1306	190	19	adipocyte	adipocyte	ADJ
dti-1306	190	20	differentiation	differentiation	NOUN
dti-1306	190	21	process	process	NOUN
dti-1306	190	22	in	in	ADP
dti-1306	190	23	human	human	ADJ
dti-1306	190	24	primary	primary	ADJ
dti-1306	190	25	adipocytes	adipocyte	NOUN
dti-1306	190	26	(	(	PUNCT
dti-1306	190	27	esau	esau	PROPN
dti-1306	190	28	et	et	PROPN
dti-1306	190	29	al	al	PROPN
dti-1306	190	30	.	.	PROPN
dti-1306	190	31	2004	2004	NUM
dti-1306	190	32	)	)	PUNCT
dti-1306	190	33	.	.	PUNCT
dti-1306	191	1	major	major	ADJ
dti-1306	191	2	hurdles	hurdle	NOUN
dti-1306	191	3	are	be	AUX
dti-1306	191	4	expected	expect	VERB
dti-1306	191	5	before	before	SCONJ
dti-1306	191	6	a	a	DET
dti-1306	191	7	mirna	mirna	NOUN
dti-1306	191	8	-	-	PUNCT
dti-1306	191	9	based	base	VERB
dti-1306	191	10	drug	drug	NOUN
dti-1306	191	11	is	be	AUX
dti-1306	191	12	successfully	successfully	ADV
dti-1306	191	13	developed	develop	VERB
dti-1306	191	14	against	against	ADP
dti-1306	191	15	cancer	cancer	NOUN
dti-1306	191	16	.	.	PUNCT
dti-1306	192	1	in	in	ADP
dti-1306	192	2	fairness	fairness	NOUN
dti-1306	192	3	this	this	PRON
dti-1306	192	4	is	be	AUX
dti-1306	192	5	only	only	ADV
dti-1306	192	6	the	the	DET
dti-1306	192	7	beginning	beginning	NOUN
dti-1306	192	8	of	of	ADP
dti-1306	192	9	the	the	DET
dti-1306	192	10	impact	impact	NOUN
dti-1306	192	11	of	of	ADP
dti-1306	192	12	the	the	DET
dti-1306	192	13	discovery	discovery	NOUN
dti-1306	192	14	of	of	ADP
dti-1306	192	15	mirna	mirna	NOUN
dti-1306	192	16	on	on	ADP
dti-1306	192	17	understanding	understand	VERB
dti-1306	192	18	the	the	DET
dti-1306	192	19	brain	brain	NOUN
dti-1306	192	20	tumor	tumor	NOUN
dti-1306	192	21	etiology	etiology	NOUN
dti-1306	192	22	,	,	PUNCT
dti-1306	192	23	and	and	CCONJ
dti-1306	192	24	developing	develop	VERB
dti-1306	192	25	cancer	cancer	NOUN
dti-1306	192	26	treatment	treatment	NOUN
dti-1306	192	27	strategies	strategy	NOUN
dti-1306	192	28	.	.	PUNCT
dti-1306	193	1	anti	anti	ADJ
dti-1306	193	2	-	-	ADJ
dti-1306	193	3	cancer	cancer	ADJ
dti-1306	193	4	drug	drug	NOUN
dti-1306	193	5	delivery	delivery	NOUN
dti-1306	193	6	to	to	PART
dti-1306	193	7	brain	brain	VERB
dti-1306	193	8	tumor	tumor	NOUN
dti-1306	193	9	drug	drug	NOUN
dti-1306	193	10	delivery	delivery	NOUN
dti-1306	193	11	in	in	ADP
dti-1306	193	12	the	the	DET
dti-1306	193	13	treatment	treatment	NOUN
dti-1306	193	14	of	of	ADP
dti-1306	193	15	brain	brain	NOUN
dti-1306	193	16	tumors	tumor	NOUN
dti-1306	193	17	is	be	AUX
dti-1306	193	18	a	a	DET
dti-1306	193	19	crucial	crucial	ADJ
dti-1306	193	20	consideration	consideration	NOUN
dti-1306	193	21	in	in	ADP
dti-1306	193	22	the	the	DET
dti-1306	193	23	development	development	NOUN
dti-1306	193	24	of	of	ADP
dti-1306	193	25	anticancer	anticancer	NOUN
dti-1306	193	26	agent	agent	NOUN
dti-1306	193	27	because	because	SCONJ
dti-1306	193	28	the	the	DET
dti-1306	193	29	delivery	delivery	NOUN
dti-1306	193	30	of	of	ADP
dti-1306	193	31	all	all	DET
dti-1306	193	32	substances	substance	NOUN
dti-1306	193	33	into	into	ADP
dti-1306	193	34	the	the	DET
dti-1306	193	35	brain	brain	NOUN
dti-1306	193	36	is	be	AUX
dti-1306	193	37	tightly	tightly	ADV
dti-1306	193	38	regulated	regulate	VERB
dti-1306	193	39	by	by	ADP
dti-1306	193	40	bbb	bbb	PROPN
dti-1306	193	41	.	.	PUNCT
dti-1306	194	1	brain	brain	NOUN
dti-1306	194	2	tumor	tumor	NOUN
dti-1306	194	3	cells	cell	NOUN
dti-1306	194	4	diffuse	diffuse	VERB
dti-1306	194	5	into	into	ADP
dti-1306	194	6	the	the	DET
dti-1306	194	7	normal	normal	ADJ
dti-1306	194	8	brain	brain	NOUN
dti-1306	194	9	and	and	CCONJ
dti-1306	194	10	are	be	AUX
dti-1306	194	11	protected	protect	VERB
dti-1306	194	12	by	by	ADP
dti-1306	194	13	intact	intact	ADJ
dti-1306	194	14	bbb	bbb	NOUN
dti-1306	194	15	(	(	PUNCT
dti-1306	194	16	rich	rich	ADJ
dti-1306	194	17	and	and	CCONJ
dti-1306	194	18	bigner	bigner	NOUN
dti-1306	194	19	,	,	PUNCT
dti-1306	194	20	2004	2004	NUM
dti-1306	194	21	)	)	PUNCT
dti-1306	194	22	,	,	PUNCT
dti-1306	194	23	where	where	SCONJ
dti-1306	194	24	anti	anti	ADJ
dti-1306	194	25	-	-	ADJ
dti-1306	194	26	cancer	cancer	ADJ
dti-1306	194	27	drug	drug	NOUN
dti-1306	194	28	delivery	delivery	NOUN
dti-1306	194	29	is	be	AUX
dti-1306	194	30	very	very	ADV
dti-1306	194	31	critical	critical	ADJ
dti-1306	194	32	.	.	PUNCT
dti-1306	195	1	we	we	PRON
dti-1306	195	2	showed	show	VERB
dti-1306	195	3	that	that	SCONJ
dti-1306	195	4	improved	improve	VERB
dti-1306	195	5	drug	drug	NOUN
dti-1306	195	6	delivery	delivery	NOUN
dti-1306	195	7	in	in	ADP
dti-1306	195	8	human	human	ADJ
dti-1306	195	9	glioma	glioma	NOUN
dti-1306	195	10	xenograft	xenograft	NOUN
dti-1306	195	11	models	model	NOUN
dti-1306	195	12	(	(	PUNCT
dti-1306	195	13	ningaraj	ningaraj	ADJ
dti-1306	195	14	,	,	PUNCT
dti-1306	195	15	2006	2006	NUM
dti-1306	195	16	)	)	PUNCT
dti-1306	195	17	has	have	VERB
dti-1306	195	18	the	the	DET
dti-1306	195	19	potential	potential	NOUN
dti-1306	195	20	to	to	PART
dti-1306	195	21	be	be	AUX
dti-1306	195	22	extrapolated	extrapolate	VERB
dti-1306	195	23	to	to	ADP
dti-1306	195	24	patients	patient	NOUN
dti-1306	195	25	with	with	ADP
dti-1306	195	26	brain	brain	NOUN
dti-1306	195	27	tumors	tumor	NOUN
dti-1306	195	28	for	for	ADP
dti-1306	195	29	better	well	ADJ
dti-1306	195	30	control	control	NOUN
dti-1306	195	31	of	of	ADP
dti-1306	195	32	the	the	DET
dti-1306	195	33	disease	disease	NOUN
dti-1306	195	34	.	.	PUNCT
dti-1306	196	1	in	in	ADP
dti-1306	196	2	this	this	DET
dti-1306	196	3	direction	direction	NOUN
dti-1306	196	4	,	,	PUNCT
dti-1306	196	5	our	our	PRON
dti-1306	196	6	laboratory	laboratory	NOUN
dti-1306	196	7	is	be	AUX
dti-1306	196	8	developing	develop	VERB
dti-1306	196	9	methods	method	NOUN
dti-1306	196	10	for	for	ADP
dti-1306	196	11	high	high	ADJ
dti-1306	196	12	-	-	PUNCT
dti-1306	196	13	throughput	throughput	NOUN
dti-1306	196	14	screening	screening	NOUN
dti-1306	196	15	of	of	ADP
dti-1306	196	16	rtkis	rtki	NOUN
dti-1306	196	17	for	for	ADP
dti-1306	196	18	selective	selective	ADJ
dti-1306	196	19	delivery	delivery	NOUN
dti-1306	196	20	to	to	ADP
dti-1306	196	21	brain	brain	NOUN
dti-1306	196	22	tumors	tumor	NOUN
dti-1306	196	23	,	,	PUNCT
dti-1306	196	24	simultaneously	simultaneously	ADV
dti-1306	196	25	monitor	monitor	VERB
dti-1306	196	26	dosing	dosing	NOUN
dti-1306	196	27	,	,	PUNCT
dti-1306	196	28	delivery	delivery	NOUN
dti-1306	196	29	,	,	PUNCT
dti-1306	196	30	and	and	CCONJ
dti-1306	196	31	pharmacological	pharmacological	NOUN
dti-1306	196	32	effi	effi	PROPN
dti-1306	196	33	cacy	cacy	NOUN
dti-1306	196	34	of	of	ADP
dti-1306	196	35	rtk	rtk	PROPN
dti-1306	196	36	inhibitors	inhibitor	NOUN
dti-1306	196	37	in	in	ADP
dti-1306	196	38	animal	animal	NOUN
dti-1306	196	39	brain	brain	NOUN
dti-1306	196	40	tumor	tumor	NOUN
dti-1306	196	41	models	model	NOUN
dti-1306	196	42	.	.	PUNCT
dti-1306	197	1	the	the	DET
dti-1306	197	2	challenges	challenge	NOUN
dti-1306	197	3	and	and	CCONJ
dti-1306	197	4	opportunities	opportunity	NOUN
dti-1306	197	5	of	of	ADP
dti-1306	197	6	the	the	DET
dti-1306	197	7	biochemical	biochemical	ADJ
dti-1306	197	8	modulation	modulation	NOUN
dti-1306	197	9	of	of	ADP
dti-1306	197	10	bbb	bbb	PROPN
dti-1306	197	11	for	for	ADP
dti-1306	197	12	selective	selective	ADJ
dti-1306	197	13	drug	drug	NOUN
dti-1306	197	14	delivery	delivery	NOUN
dti-1306	197	15	to	to	PART
dti-1306	197	16	brain	brain	NOUN
dti-1306	197	17	tumor	tumor	NOUN
dti-1306	197	18	was	be	AUX
dti-1306	197	19	reviewed	review	VERB
dti-1306	197	20	recently	recently	ADV
dti-1306	197	21	(	(	PUNCT
dti-1306	197	22	ningaraj	ningaraj	ADJ
dti-1306	197	23	,	,	PUNCT
dti-1306	197	24	2006	2006	NUM
dti-1306	197	25	)	)	PUNCT
dti-1306	197	26	.	.	PUNCT
dti-1306	198	1	we	we	PRON
dti-1306	198	2	showed	show	VERB
dti-1306	198	3	that	that	SCONJ
dti-1306	198	4	intravenously	intravenously	ADV
dti-1306	198	5	administered	administer	VERB
dti-1306	198	6	,	,	PUNCT
dti-1306	198	7	potassium	potassium	NOUN
dti-1306	198	8	channel	channel	NOUN
dti-1306	198	9	agonists	agonist	NOUN
dti-1306	198	10	increase	increase	VERB
dti-1306	198	11	tmz	tmz	PROPN
dti-1306	198	12	(	(	PUNCT
dti-1306	198	13	fig	fig	NOUN
dti-1306	198	14	.	.	PUNCT
dti-1306	198	15	2	2	NUM
dti-1306	198	16	)	)	PUNCT
dti-1306	198	17	and	and	CCONJ
dti-1306	198	18	her-2	her-2	PRON
dti-1306	198	19	mab	mab	PROPN
dti-1306	198	20	(	(	PUNCT
dti-1306	198	21	herceptin	herceptin	PROPN
dti-1306	198	22	)	)	PUNCT
dti-1306	198	23	(	(	PUNCT
dti-1306	198	24	ningaraj	ningaraj	ADJ
dti-1306	198	25	,	,	PUNCT
dti-1306	198	26	rao	rao	NOUN
dti-1306	198	27	and	and	CCONJ
dti-1306	198	28	black	black	ADJ
dti-1306	198	29	,	,	PUNCT
dti-1306	198	30	2003b	2003b	NUM
dti-1306	198	31	)	)	PUNCT
dti-1306	198	32	delivery	delivery	NOUN
dti-1306	198	33	across	across	ADP
dti-1306	198	34	the	the	DET
dti-1306	198	35	btb	btb	NOUN
dti-1306	198	36	to	to	PART
dti-1306	198	37	elicit	elicit	VERB
dti-1306	198	38	anti	anti	ADJ
dti-1306	198	39	-	-	ADJ
dti-1306	198	40	tumor	tumor	ADJ
dti-1306	198	41	activity	activity	NOUN
dti-1306	198	42	and	and	CCONJ
dti-1306	198	43	increase	increase	VERB
dti-1306	198	44	survival	survival	NOUN
dti-1306	198	45	in	in	ADP
dti-1306	198	46	nude	nude	ADJ
dti-1306	198	47	mice	mouse	NOUN
dti-1306	198	48	with	with	ADP
dti-1306	198	49	intracranially	intracranially	ADV
dti-1306	198	50	implanted	implant	VERB
dti-1306	198	51	human	human	ADJ
dti-1306	198	52	glial	glial	ADJ
dti-1306	198	53	tumor	tumor	NOUN
dti-1306	198	54	.	.	PUNCT
dti-1306	199	1	our	our	PRON
dti-1306	199	2	study	study	NOUN
dti-1306	199	3	suggested	suggest	VERB
dti-1306	199	4	that	that	SCONJ
dti-1306	199	5	the	the	DET
dti-1306	199	6	btb	btb	NOUN
dti-1306	199	7	allows	allow	VERB
dti-1306	199	8	a	a	DET
dti-1306	199	9	small	small	ADJ
dti-1306	199	10	amount	amount	NOUN
dti-1306	199	11	of	of	ADP
dti-1306	199	12	tmz	tmz	NOUN
dti-1306	199	13	into	into	ADP
dti-1306	199	14	brain	brain	NOUN
dti-1306	199	15	tumors	tumor	NOUN
dti-1306	199	16	.	.	PUNCT
dti-1306	200	1	potassium	potassium	NOUN
dti-1306	200	2	channel	channel	NOUN
dti-1306	200	3	agonist	agonist	NOUN
dti-1306	200	4	-	-	PUNCT
dti-1306	200	5	mediated	mediate	VERB
dti-1306	200	6	biochemical	biochemical	ADJ
dti-1306	200	7	modulation	modulation	NOUN
dti-1306	200	8	signifi	signifi	NOUN
dti-1306	200	9	cantly	cantly	ADV
dti-1306	200	10	increased	increase	VERB
dti-1306	200	11	btb	btb	NOUN
dti-1306	200	12	permeability	permeability	NOUN
dti-1306	200	13	allowing	allow	VERB
dti-1306	200	14	greater	great	ADJ
dti-1306	200	15	amounts	amount	NOUN
dti-1306	200	16	of	of	ADP
dti-1306	200	17	figure	figure	NOUN
dti-1306	200	18	2	2	NUM
dti-1306	200	19	.	.	PUNCT
dti-1306	200	20	quantitative	quantitative	ADJ
dti-1306	200	21	increases	increase	NOUN
dti-1306	200	22	in	in	ADP
dti-1306	200	23	btb	btb	NOUN
dti-1306	200	24	permeability	permeability	NOUN
dti-1306	200	25	.	.	PUNCT
dti-1306	201	1	a	a	DET
dti-1306	201	2	signifi	signifi	NOUN
dti-1306	201	3	ca	can	AUX
dti-1306	201	4	nt	not	PART
dti-1306	201	5	increase	increase	VERB
dti-1306	201	6	in	in	ADP
dti-1306	201	7	the	the	DET
dti-1306	201	8	mean	mean	NOUN
dti-1306	201	9	ki	ki	PROPN
dti-1306	201	10	for	for	ADP
dti-1306	201	11	[	[	X
dti-1306	201	12	14c]-temozolomide	14c]-temozolomide	PROPN
dti-1306	201	13	(	(	PUNCT
dti-1306	201	14	tmz	tmz	PROPN
dti-1306	201	15	)	)	PUNCT
dti-1306	201	16	after	after	ADP
dti-1306	201	17	i.v	i.v	PROPN
dti-1306	201	18	.	.	PUNCT
dti-1306	201	19	infusion	infusion	NOUN
dti-1306	201	20	of	of	ADP
dti-1306	201	21	100	100	NUM
dti-1306	201	22	µg	µg	ADV
dti-1306	201	23	/	/	SYM
dti-1306	201	24	kg	kg	NOUN
dti-1306	201	25	/	/	SYM
dti-1306	201	26	min	min	NOUN
dti-1306	201	27	for	for	ADP
dti-1306	201	28	15	15	NUM
dti-1306	201	29	min	min	NOUN
dti-1306	201	30	of	of	ADP
dti-1306	201	31	ns-1619	ns-1619	NOUN
dti-1306	201	32	and	and	CCONJ
dti-1306	201	33	ms	ms	NOUN
dti-1306	201	34	compared	compare	VERB
dti-1306	201	35	to	to	ADP
dti-1306	201	36	a	a	DET
dti-1306	201	37	vehicle	vehicle	NOUN
dti-1306	201	38	-	-	PUNCT
dti-1306	201	39	treated	treat	VERB
dti-1306	201	40	group	group	NOUN
dti-1306	201	41	was	be	AUX
dti-1306	201	42	observed	observe	VERB
dti-1306	201	43	.	.	PUNCT
dti-1306	202	1	the	the	DET
dti-1306	202	2	increase	increase	NOUN
dti-1306	202	3	in	in	ADP
dti-1306	202	4	[	[	X
dti-1306	202	5	14c]-tmz	14c]-tmz	NUM
dti-1306	202	6	uptake	uptake	ADJ
dti-1306	202	7	in	in	ADP
dti-1306	202	8	tumor	tumor	NOUN
dti-1306	202	9	center	center	NOUN
dti-1306	202	10	was	be	AUX
dti-1306	202	11	signifi	signifi	NOUN
dti-1306	202	12	ca	can	AUX
dti-1306	202	13	nt	not	PART
dti-1306	202	14	although	although	SCONJ
dti-1306	202	15	a	a	DET
dti-1306	202	16	slight	slight	ADJ
dti-1306	202	17	increase	increase	NOUN
dti-1306	202	18	in	in	ADP
dti-1306	202	19	uptake	uptake	NOUN
dti-1306	202	20	of	of	ADP
dti-1306	202	21	the	the	DET
dti-1306	202	22	radiotracer	radiotracer	NOUN
dti-1306	202	23	was	be	AUX
dti-1306	202	24	observed	observe	VERB
dti-1306	202	25	in	in	ADP
dti-1306	202	26	the	the	DET
dti-1306	202	27	brain	brain	NOUN
dti-1306	202	28	tissue	tissue	NOUN
dti-1306	202	29	-	-	PUNCT
dti-1306	202	30	surrounding	surround	VERB
dti-1306	202	31	tumor	tumor	NOUN
dti-1306	202	32	.	.	PUNCT
dti-1306	203	1	no	no	PRON
dti-1306	204	1	[	[	X
dti-1306	204	2	14c]-tmz	14c]-tmz	NUM
dti-1306	204	3	uptake	uptake	ADJ
dti-1306	204	4	in	in	ADP
dti-1306	204	5	contralateral	contralateral	ADJ
dti-1306	204	6	normal	normal	ADJ
dti-1306	204	7	brain	brain	NOUN
dti-1306	204	8	,	,	PUNCT
dti-1306	204	9	which	which	PRON
dti-1306	204	10	served	serve	VERB
dti-1306	204	11	as	as	ADP
dti-1306	204	12	internal	internal	ADJ
dti-1306	204	13	control	control	NOUN
dti-1306	204	14	,	,	PUNCT
dti-1306	204	15	was	be	AUX
dti-1306	204	16	observed	observe	VERB
dti-1306	204	17	in	in	ADP
dti-1306	204	18	all	all	DET
dti-1306	204	19	the	the	DET
dti-1306	204	20	groups	group	NOUN
dti-1306	204	21	.	.	PUNCT
dti-1306	205	1	data	datum	NOUN
dti-1306	205	2	are	be	AUX
dti-1306	205	3	presented	present	VERB
dti-1306	205	4	as	as	ADP
dti-1306	205	5	mean	mean	PROPN
dti-1306	205	6	±	±	NUM
dti-1306	205	7	s.d	s.d	PROPN
dti-1306	205	8	(	(	PUNCT
dti-1306	205	9	n	n	NOUN
dti-1306	205	10	=	=	SYM
dti-1306	205	11	6	6	NUM
dti-1306	205	12	)	)	PUNCT
dti-1306	205	13	,	,	PUNCT
dti-1306	205	14	*	*	PUNCT
dti-1306	206	1	*	*	PUNCT
dti-1306	206	2	*	*	PUNCT
dti-1306	206	3	p	p	X
dti-1306	206	4	<	<	X
dti-1306	206	5	0.001	0.001	NUM
dti-1306	206	6	versus	versus	ADP
dti-1306	206	7	vehicle	vehicle	NOUN
dti-1306	206	8	-	-	PUNCT
dti-1306	206	9	treated	treat	VERB
dti-1306	206	10	group	group	NOUN
dti-1306	206	11	.	.	PUNCT
dti-1306	207	1	precaution	precaution	NOUN
dti-1306	207	2	was	be	AUX
dti-1306	207	3	taken	take	VERB
dti-1306	207	4	to	to	PART
dti-1306	207	5	avoid	avoid	VERB
dti-1306	207	6	necrotic	necrotic	ADJ
dti-1306	207	7	area	area	NOUN
dti-1306	207	8	during	during	ADP
dti-1306	207	9	the	the	DET
dti-1306	207	10	ki	ki	PROPN
dti-1306	207	11	measurement	measurement	NOUN
dti-1306	207	12	by	by	ADP
dti-1306	207	13	comparing	compare	VERB
dti-1306	207	14	the	the	DET
dti-1306	207	15	qar	qar	PROPN
dti-1306	207	16	brain	brain	NOUN
dti-1306	207	17	section	section	NOUN
dti-1306	207	18	with	with	ADP
dti-1306	207	19	a	a	DET
dti-1306	207	20	corresponding	corresponding	ADJ
dti-1306	207	21	h&e	h&e	PROPN
dti-1306	207	22	stained	stain	VERB
dti-1306	207	23	serial	serial	ADJ
dti-1306	207	24	brain	brain	NOUN
dti-1306	207	25	tumor	tumor	NOUN
dti-1306	207	26	section	section	NOUN
dti-1306	207	27	.	.	PUNCT
dti-1306	208	1	205	205	NUM
dti-1306	208	2	targeted	target	VERB
dti-1306	208	3	brain	brain	NOUN
dti-1306	208	4	tumor	tumor	NOUN
dti-1306	208	5	treatment	treatment	NOUN
dti-1306	208	6	drug	drug	NOUN
dti-1306	208	7	target	target	NOUN
dti-1306	208	8	insights	insight	NOUN
dti-1306	208	9	2007	2007	NUM
dti-1306	208	10	:	:	SYM
dti-1306	208	11	2	2	NUM
dti-1306	208	12	tmz	tmz	NOUN
dti-1306	208	13	,	,	PUNCT
dti-1306	208	14	selectively	selectively	ADV
dti-1306	208	15	to	to	PART
dti-1306	208	16	reach	reach	VERB
dti-1306	208	17	brain	brain	NOUN
dti-1306	208	18	tumor	tumor	NOUN
dti-1306	208	19	and	and	CCONJ
dti-1306	208	20	brain	brain	NOUN
dti-1306	208	21	tissue	tissue	NOUN
dti-1306	208	22	surrounding	surround	VERB
dti-1306	208	23	tumor	tumor	NOUN
dti-1306	208	24	,	,	PUNCT
dti-1306	208	25	which	which	PRON
dti-1306	208	26	represents	represent	VERB
dti-1306	208	27	proliferating	proliferate	VERB
dti-1306	208	28	edges	edge	NOUN
dti-1306	208	29	of	of	ADP
dti-1306	208	30	tumor	tumor	NOUN
dti-1306	208	31	where	where	SCONJ
dti-1306	208	32	the	the	DET
dti-1306	208	33	bbb	bbb	NOUN
dti-1306	208	34	may	may	AUX
dti-1306	208	35	be	be	AUX
dti-1306	208	36	intact	intact	ADJ
dti-1306	208	37	(	(	PUNCT
dti-1306	208	38	pardridge	pardridge	VERB
dti-1306	208	39	et	et	PROPN
dti-1306	208	40	al	al	PROPN
dti-1306	208	41	.	.	PROPN
dti-1306	208	42	1992	1992	NUM
dti-1306	208	43	)	)	PUNCT
dti-1306	208	44	.	.	PUNCT
dti-1306	209	1	furthermore	furthermore	ADV
dti-1306	209	2	,	,	PUNCT
dti-1306	209	3	we	we	PRON
dti-1306	209	4	showed	show	VERB
dti-1306	209	5	that	that	SCONJ
dti-1306	209	6	trastuzumab	trastuzumab	NOUN
dti-1306	209	7	combined	combine	VERB
dti-1306	209	8	with	with	ADP
dti-1306	209	9	tmz	tmz	PROPN
dti-1306	209	10	co	co	VERB
dti-1306	209	11	-	-	VERB
dti-1306	209	12	administered	administer	VERB
dti-1306	209	13	with	with	ADP
dti-1306	209	14	potassium	potassium	NOUN
dti-1306	209	15	channel	channel	NOUN
dti-1306	209	16	agonists	agonist	NOUN
dti-1306	209	17	signifi	signifi	VERB
dti-1306	209	18	cantly	cantly	ADV
dti-1306	209	19	increased	increase	VERB
dti-1306	209	20	survival	survival	NOUN
dti-1306	209	21	rates	rate	NOUN
dti-1306	209	22	in	in	ADP
dti-1306	209	23	mice	mouse	NOUN
dti-1306	209	24	with	with	ADP
dti-1306	209	25	intracranial	intracranial	ADJ
dti-1306	209	26	gbm	gbm	PROPN
dti-1306	209	27	xenograft	xenograft	NOUN
dti-1306	209	28	(	(	PUNCT
dti-1306	209	29	unpublished	unpublished	ADJ
dti-1306	209	30	data	datum	NOUN
dti-1306	209	31	)	)	PUNCT
dti-1306	209	32	.	.	PUNCT
dti-1306	210	1	these	these	DET
dti-1306	210	2	results	result	NOUN
dti-1306	210	3	are	be	AUX
dti-1306	210	4	consistent	consistent	ADJ
dti-1306	210	5	with	with	ADP
dti-1306	210	6	our	our	PRON
dti-1306	210	7	earlier	early	ADJ
dti-1306	210	8	study	study	NOUN
dti-1306	210	9	,	,	PUNCT
dti-1306	210	10	where	where	SCONJ
dti-1306	210	11	we	we	PRON
dti-1306	210	12	showed	show	VERB
dti-1306	210	13	that	that	SCONJ
dti-1306	210	14	potassium	potassium	NOUN
dti-1306	210	15	channel	channel	NOUN
dti-1306	210	16	activator	activator	NOUN
dti-1306	210	17	(	(	PUNCT
dti-1306	210	18	minoxidil	minoxidil	ADJ
dti-1306	210	19	sulfate	sulfate	NOUN
dti-1306	210	20	:	:	PUNCT
dti-1306	210	21	ms	ms	ADJ
dti-1306	210	22	)	)	PUNCT
dti-1306	210	23	infusion	infusion	NOUN
dti-1306	210	24	selectively	selectively	ADV
dti-1306	210	25	enhanced	enhance	VERB
dti-1306	210	26	carboplatin	carboplatin	NOUN
dti-1306	210	27	delivery	delivery	NOUN
dti-1306	210	28	to	to	PART
dti-1306	210	29	tumor	tumor	NOUN
dti-1306	210	30	tissue	tissue	NOUN
dti-1306	210	31	without	without	ADP
dti-1306	210	32	increasing	increase	VERB
dti-1306	210	33	delivery	delivery	NOUN
dti-1306	210	34	to	to	ADP
dti-1306	210	35	normal	normal	ADJ
dti-1306	210	36	brain	brain	NOUN
dti-1306	210	37	(	(	PUNCT
dti-1306	210	38	ningaraj	ningaraj	ADJ
dti-1306	210	39	,	,	PUNCT
dti-1306	210	40	rao	rao	NOUN
dti-1306	210	41	and	and	CCONJ
dti-1306	210	42	black	black	ADJ
dti-1306	210	43	,	,	PUNCT
dti-1306	210	44	2003b	2003b	NUM
dti-1306	210	45	)	)	PUNCT
dti-1306	210	46	.	.	PUNCT
dti-1306	211	1	ms	ms	PROPN
dti-1306	211	2	co	co	NOUN
dti-1306	211	3	-	-	NOUN
dti-1306	211	4	infusion	infusion	NOUN
dti-1306	211	5	with	with	ADP
dti-1306	211	6	carboplatin	carboplatin	NOUN
dti-1306	211	7	in	in	ADP
dti-1306	211	8	rats	rat	NOUN
dti-1306	211	9	resulted	result	VERB
dti-1306	211	10	in	in	ADP
dti-1306	211	11	tumor	tumor	NOUN
dti-1306	211	12	regression	regression	NOUN
dti-1306	211	13	,	,	PUNCT
dti-1306	211	14	significantly	significantly	ADV
dti-1306	211	15	increasing	increase	VERB
dti-1306	211	16	survival	survival	NOUN
dti-1306	211	17	(	(	PUNCT
dti-1306	211	18	black	black	ADJ
dti-1306	211	19	and	and	CCONJ
dti-1306	211	20	ningaraj	ningaraj	ADJ
dti-1306	211	21	,	,	PUNCT
dti-1306	211	22	2004	2004	NUM
dti-1306	211	23	)	)	PUNCT
dti-1306	211	24	.	.	PUNCT
dti-1306	212	1	the	the	DET
dti-1306	212	2	ability	ability	NOUN
dti-1306	212	3	to	to	PART
dti-1306	212	4	deliver	deliver	VERB
dti-1306	212	5	her-2	her-2	NUM
dti-1306	212	6	neu	neu	NOUN
dti-1306	212	7	targeting	target	VERB
dti-1306	212	8	drug	drug	NOUN
dti-1306	212	9	herceptin	herceptin	NOUN
dti-1306	212	10	(	(	PUNCT
dti-1306	212	11	trastuzumab	trastuzumab	NOUN
dti-1306	212	12	)	)	PUNCT
dti-1306	212	13	by	by	ADP
dti-1306	212	14	potassium	potassium	NOUN
dti-1306	212	15	channel	channel	NOUN
dti-1306	212	16	-	-	PUNCT
dti-1306	212	17	mediated	mediate	VERB
dti-1306	212	18	btb	btb	NOUN
dti-1306	212	19	modulation	modulation	NOUN
dti-1306	212	20	in	in	ADP
dti-1306	212	21	human	human	ADJ
dti-1306	212	22	xenografts	xenograft	NOUN
dti-1306	212	23	may	may	AUX
dti-1306	212	24	be	be	AUX
dti-1306	212	25	clinically	clinically	ADV
dti-1306	212	26	useful	useful	ADJ
dti-1306	212	27	because	because	SCONJ
dti-1306	212	28	gbms	gbms	NOUN
dti-1306	212	29	frequently	frequently	ADV
dti-1306	212	30	have	have	AUX
dti-1306	212	31	altered	alter	VERB
dti-1306	212	32	receptor	receptor	NOUN
dti-1306	212	33	tyrosine	tyrosine	PROPN
dti-1306	212	34	kinase	kinase	PROPN
dti-1306	212	35	genes	gene	NOUN
dti-1306	212	36	(	(	PUNCT
dti-1306	212	37	fuller	full	ADJ
dti-1306	212	38	and	and	CCONJ
dti-1306	212	39	bigner	bigner	NOUN
dti-1306	212	40	,	,	PUNCT
dti-1306	212	41	1992	1992	NUM
dti-1306	212	42	)	)	PUNCT
dti-1306	212	43	,	,	PUNCT
dti-1306	212	44	including	include	VERB
dti-1306	212	45	her-2	her-2	NUM
dti-1306	212	46	neu	neu	NOUN
dti-1306	212	47	that	that	PRON
dti-1306	212	48	is	be	AUX
dti-1306	212	49	over	over	ADV
dti-1306	212	50	expressed	express	VERB
dti-1306	212	51	in	in	ADP
dti-1306	212	52	about	about	ADV
dti-1306	212	53	17%–20	17%–20	NUM
dti-1306	212	54	%	%	NOUN
dti-1306	212	55	of	of	ADP
dti-1306	212	56	gbm	gbm	PROPN
dti-1306	212	57	patients	patient	NOUN
dti-1306	212	58	(	(	PUNCT
dti-1306	212	59	forseen	forseen	VERB
dti-1306	212	60	et	et	PROPN
dti-1306	212	61	al	al	PROPN
dti-1306	212	62	.	.	PROPN
dti-1306	212	63	2002	2002	NUM
dti-1306	212	64	)	)	PUNCT
dti-1306	212	65	resulting	result	VERB
dti-1306	212	66	in	in	ADP
dti-1306	212	67	poor	poor	ADJ
dti-1306	212	68	prognosis	prognosis	NOUN
dti-1306	212	69	and	and	CCONJ
dti-1306	212	70	patient	patient	ADJ
dti-1306	212	71	survival	survival	NOUN
dti-1306	212	72	.	.	PUNCT
dti-1306	213	1	a	a	DET
dti-1306	213	2	molecular	molecular	ADJ
dti-1306	213	3	target	target	NOUN
dti-1306	213	4	-	-	PUNCT
dti-1306	213	5	based	base	VERB
dti-1306	213	6	therapy	therapy	NOUN
dti-1306	213	7	using	use	VERB
dti-1306	213	8	trastuzumab	trastuzumab	NOUN
dti-1306	213	9	and	and	CCONJ
dti-1306	213	10	pertuzumab	pertuzumab	NOUN
dti-1306	213	11	(	(	PUNCT
dti-1306	213	12	omnitarg	omnitarg	NOUN
dti-1306	213	13	,	,	PUNCT
dti-1306	213	14	2c4	2c4	NUM
dti-1306	213	15	)	)	PUNCT
dti-1306	213	16	is	be	AUX
dti-1306	213	17	developed	develop	VERB
dti-1306	213	18	by	by	ADP
dti-1306	213	19	genentech	genentech	PROPN
dti-1306	213	20	inc	inc	PROPN
dti-1306	213	21	.	.	PROPN
dti-1306	213	22	,	,	PUNCT
dti-1306	213	23	for	for	ADP
dti-1306	213	24	brain	brain	NOUN
dti-1306	213	25	tumor	tumor	NOUN
dti-1306	213	26	,	,	PUNCT
dti-1306	213	27	but	but	CCONJ
dti-1306	213	28	their	their	PRON
dti-1306	213	29	delivery	delivery	NOUN
dti-1306	213	30	across	across	ADP
dti-1306	213	31	the	the	DET
dti-1306	213	32	btb	btb	NOUN
dti-1306	213	33	remains	remain	VERB
dti-1306	213	34	a	a	DET
dti-1306	213	35	major	major	ADJ
dti-1306	213	36	concern	concern	NOUN
dti-1306	213	37	.	.	PUNCT
dti-1306	214	1	molecular	molecular	ADJ
dti-1306	214	2	medicine	medicine	NOUN
dti-1306	214	3	to	to	PART
dti-1306	214	4	conclude	conclude	VERB
dti-1306	214	5	,	,	PUNCT
dti-1306	214	6	the	the	DET
dti-1306	214	7	future	future	NOUN
dti-1306	214	8	of	of	ADP
dti-1306	214	9	molecular	molecular	ADJ
dti-1306	214	10	targeted	target	VERB
dti-1306	214	11	therapy	therapy	NOUN
dti-1306	214	12	is	be	AUX
dti-1306	214	13	to	to	PART
dti-1306	214	14	achieve	achieve	VERB
dti-1306	214	15	customized	customized	ADJ
dti-1306	214	16	treatment	treatment	NOUN
dti-1306	214	17	strategy	strategy	NOUN
dti-1306	214	18	for	for	ADP
dti-1306	214	19	brain	brain	NOUN
dti-1306	214	20	tumor	tumor	NOUN
dti-1306	214	21	patients	patient	NOUN
dti-1306	214	22	,	,	PUNCT
dti-1306	214	23	where	where	SCONJ
dti-1306	214	24	individual	individual	ADJ
dti-1306	214	25	patient	patient	ADJ
dti-1306	214	26	treatment	treatment	NOUN
dti-1306	214	27	will	will	AUX
dti-1306	214	28	be	be	AUX
dti-1306	214	29	based	base	VERB
dti-1306	214	30	on	on	ADP
dti-1306	214	31	the	the	DET
dti-1306	214	32	molecular	molecular	ADJ
dti-1306	214	33	profi	profi	NOUN
dti-1306	214	34	le	le	X
dti-1306	214	35	of	of	ADP
dti-1306	214	36	the	the	DET
dti-1306	214	37	disease	disease	NOUN
dti-1306	214	38	.	.	PUNCT
dti-1306	215	1	the	the	DET
dti-1306	215	2	information	information	NOUN
dti-1306	215	3	based	base	VERB
dti-1306	215	4	on	on	ADP
dti-1306	215	5	the	the	DET
dti-1306	215	6	changing	change	VERB
dti-1306	215	7	levels	level	NOUN
dti-1306	215	8	of	of	ADP
dti-1306	215	9	active	active	ADJ
dti-1306	215	10	genes	gene	NOUN
dti-1306	215	11	/	/	SYM
dti-1306	215	12	proteins	protein	NOUN
dti-1306	215	13	inside	inside	ADP
dti-1306	215	14	tumor	tumor	NOUN
dti-1306	215	15	cells	cell	NOUN
dti-1306	215	16	in	in	ADP
dti-1306	215	17	response	response	NOUN
dti-1306	215	18	to	to	ADP
dti-1306	215	19	an	an	DET
dti-1306	215	20	anti	anti	ADJ
dti-1306	215	21	-	-	ADJ
dti-1306	215	22	cancer	cancer	ADJ
dti-1306	215	23	drug	drug	NOUN
dti-1306	215	24	,	,	PUNCT
dti-1306	215	25	could	could	AUX
dti-1306	215	26	help	help	VERB
dti-1306	215	27	physicians	physician	NOUN
dti-1306	215	28	to	to	PART
dti-1306	215	29	determine	determine	VERB
dti-1306	215	30	early	early	ADV
dti-1306	215	31	in	in	ADP
dti-1306	215	32	the	the	DET
dti-1306	215	33	treatment	treatment	NOUN
dti-1306	215	34	whether	whether	SCONJ
dti-1306	215	35	a	a	DET
dti-1306	215	36	drug	drug	NOUN
dti-1306	215	37	works	work	VERB
dti-1306	215	38	effectively	effectively	ADV
dti-1306	215	39	or	or	CCONJ
dti-1306	215	40	not	not	PART
dti-1306	215	41	.	.	PUNCT
dti-1306	216	1	researchers	researcher	NOUN
dti-1306	216	2	have	have	VERB
dti-1306	216	3	identifi	identifi	PROPN
dti-1306	216	4	ed	ed	PROPN
dti-1306	216	5	gene	gene	NOUN
dti-1306	216	6	/	/	SYM
dti-1306	216	7	protein	protein	NOUN
dti-1306	216	8	markers	marker	NOUN
dti-1306	216	9	that	that	PRON
dti-1306	216	10	are	be	AUX
dti-1306	216	11	useful	useful	ADJ
dti-1306	216	12	in	in	ADP
dti-1306	216	13	individualizing	individualize	VERB
dti-1306	216	14	treatment	treatment	NOUN
dti-1306	216	15	in	in	ADP
dti-1306	216	16	prostate	prostate	NOUN
dti-1306	216	17	,	,	PUNCT
dti-1306	216	18	breast	breast	NOUN
dti-1306	216	19	,	,	PUNCT
dti-1306	216	20	and	and	CCONJ
dti-1306	216	21	ovarian	ovarian	ADJ
dti-1306	216	22	cancer	cancer	NOUN
dti-1306	216	23	patients	patient	NOUN
dti-1306	216	24	.	.	PUNCT
dti-1306	217	1	although	although	SCONJ
dti-1306	217	2	,	,	PUNCT
dti-1306	217	3	brain	brain	NOUN
dti-1306	217	4	tumor	tumor	NOUN
dti-1306	217	5	tissue	tissue	NOUN
dti-1306	217	6	is	be	AUX
dti-1306	217	7	heterogeneous	heterogeneous	ADJ
dti-1306	217	8	,	,	PUNCT
dti-1306	217	9	the	the	DET
dti-1306	217	10	genetic	genetic	ADJ
dti-1306	217	11	profi	profi	PROPN
dti-1306	217	12	ling	ling	PROPN
dti-1306	217	13	of	of	ADP
dti-1306	217	14	tumor	tumor	NOUN
dti-1306	217	15	tissue	tissue	NOUN
dti-1306	217	16	gives	give	VERB
dti-1306	217	17	valuable	valuable	ADJ
dti-1306	217	18	molecular	molecular	ADJ
dti-1306	217	19	information	information	NOUN
dti-1306	217	20	.	.	PUNCT
dti-1306	218	1	as	as	ADP
dti-1306	218	2	a	a	DET
dti-1306	218	3	case	case	NOUN
dti-1306	218	4	in	in	ADP
dti-1306	218	5	point	point	NOUN
dti-1306	218	6	,	,	PUNCT
dti-1306	218	7	high	high	ADJ
dti-1306	218	8	-	-	PUNCT
dti-1306	218	9	throughput	throughput	NOUN
dti-1306	218	10	gene	gene	NOUN
dti-1306	218	11	profi	profi	PROPN
dti-1306	218	12	ling	ling	PROPN
dti-1306	218	13	of	of	ADP
dti-1306	218	14	brain	brain	NOUN
dti-1306	218	15	tumor	tumor	NOUN
dti-1306	218	16	biopsy	biopsy	NOUN
dti-1306	218	17	samples	sample	NOUN
dti-1306	218	18	by	by	ADP
dti-1306	218	19	gene	gene	NOUN
dti-1306	218	20	array	array	NOUN
dti-1306	218	21	technique	technique	NOUN
dti-1306	218	22	can	can	AUX
dti-1306	218	23	be	be	AUX
dti-1306	218	24	compared	compare	VERB
dti-1306	218	25	with	with	ADP
dti-1306	218	26	genomic	genomic	ADJ
dti-1306	218	27	data	datum	NOUN
dti-1306	218	28	generated	generate	VERB
dti-1306	218	29	using	use	VERB
dti-1306	218	30	tumor	tumor	NOUN
dti-1306	218	31	samples	sample	NOUN
dti-1306	218	32	to	to	PART
dti-1306	218	33	predict	predict	VERB
dti-1306	218	34	whether	whether	SCONJ
dti-1306	218	35	patients	patient	NOUN
dti-1306	218	36	would	would	AUX
dti-1306	218	37	benefit	benefit	VERB
dti-1306	218	38	from	from	ADP
dti-1306	218	39	anti	anti	ADJ
dti-1306	218	40	-	-	ADJ
dti-1306	218	41	cancer	cancer	ADJ
dti-1306	218	42	drug	drug	NOUN
dti-1306	218	43	(	(	PUNCT
dti-1306	218	44	like	like	ADP
dti-1306	218	45	gleevec	gleevec	PROPN
dti-1306	218	46	)	)	PUNCT
dti-1306	218	47	treatment	treatment	NOUN
dti-1306	218	48	or	or	CCONJ
dti-1306	218	49	by	by	ADP
dti-1306	218	50	potassium	potassium	NOUN
dti-1306	218	51	channel	channel	NOUN
dti-1306	218	52	modulation	modulation	NOUN
dti-1306	218	53	in	in	ADP
dti-1306	218	54	tumor	tumor	NOUN
dti-1306	218	55	and	and	CCONJ
dti-1306	218	56	tumor	tumor	NOUN
dti-1306	218	57	vascular	vascular	ADJ
dti-1306	218	58	endothelial	endothelial	ADJ
dti-1306	218	59	cells	cell	NOUN
dti-1306	218	60	.	.	PUNCT
dti-1306	219	1	acknowledgments	acknowledgment	NOUN
dti-1306	219	2	we	we	PRON
dti-1306	219	3	thank	thank	VERB
dti-1306	219	4	robert	robert	PROPN
dti-1306	219	5	bishop	bishop	PROPN
dti-1306	219	6	,	,	PUNCT
dti-1306	219	7	ph.d	ph.d	PROPN
dti-1306	219	8	.	.	PROPN
dti-1306	219	9	,	,	PUNCT
dti-1306	219	10	schering	schering	NOUN
dti-1306	219	11	-	-	PUNCT
dti-1306	219	12	plough	plough	NOUN
dti-1306	219	13	research	research	NOUN
dti-1306	219	14	institute	institute	PROPN
dti-1306	219	15	,	,	PUNCT
dti-1306	219	16	kenilworth	kenilworth	PROPN
dti-1306	219	17	,	,	PUNCT
dti-1306	219	18	new	new	PROPN
dti-1306	219	19	jersey	jersey	PROPN
dti-1306	219	20	for	for	ADP
dti-1306	219	21	kindly	kindly	ADV
dti-1306	219	22	providing	provide	VERB
dti-1306	219	23	radiolabeled	radiolabele	VERB
dti-1306	219	24	and	and	CCONJ
dti-1306	219	25	non	non	ADJ
dti-1306	219	26	-	-	ADJ
dti-1306	219	27	radiolabeled	radiolabeled	ADJ
dti-1306	219	28	temozolomide	temozolomide	NOUN
dti-1306	219	29	.	.	PUNCT
dti-1306	220	1	we	we	PRON
dti-1306	220	2	also	also	ADV
dti-1306	220	3	acknowledge	acknowledge	VERB
dti-1306	220	4	american	american	PROPN
dti-1306	220	5	cancer	cancer	PROPN
dti-1306	220	6	society	society	PROPN
dti-1306	220	7	award	award	PROPN
dti-1306	220	8	to	to	ADP
dti-1306	220	9	nsn	nsn	PROPN
dti-1306	220	10	.	.	PROPN
dti-1306	221	1	references	reference	NOUN
dti-1306	221	2	ambros	ambros	PROPN
dti-1306	221	3	,	,	PUNCT
dti-1306	221	4	v.	v.	ADP
dti-1306	221	5	2003	2003	NUM
dti-1306	221	6	.	.	PUNCT
dti-1306	222	1	microrna	microrna	PROPN
dti-1306	222	2	pathways	pathway	NOUN
dti-1306	222	3	in	in	ADP
dti-1306	222	4	fl	fl	PROPN
dti-1306	222	5	ies	ie	NOUN
dti-1306	222	6	and	and	CCONJ
dti-1306	222	7	worms	worm	NOUN
dti-1306	222	8	:	:	PUNCT
dti-1306	222	9	growth	growth	NOUN
dti-1306	222	10	,	,	PUNCT
dti-1306	222	11	death	death	NOUN
dti-1306	222	12	,	,	PUNCT
dti-1306	222	13	fat	fat	ADJ
dti-1306	222	14	,	,	PUNCT
dti-1306	222	15	stress	stress	NOUN
dti-1306	222	16	,	,	PUNCT
dti-1306	222	17	and	and	CCONJ
dti-1306	222	18	timing	timing	NOUN
dti-1306	222	19	.	.	PUNCT
dti-1306	223	1	cell	cell	NOUN
dti-1306	223	2	,	,	PUNCT
dti-1306	223	3	113:673–6	113:673–6	NUM
dti-1306	223	4	.	.	PUNCT
dti-1306	224	1	alaminos	alaminos	PROPN
dti-1306	224	2	,	,	PUNCT
dti-1306	224	3	m.	m.	NOUN
dti-1306	224	4	et	et	PROPN
dti-1306	224	5	al	al	PROPN
dti-1306	224	6	.	.	PROPN
dti-1306	224	7	2005	2005	NUM
dti-1306	224	8	.	.	PUNCT
dti-1306	225	1	emp3	emp3	PROPN
dti-1306	225	2	,	,	PUNCT
dti-1306	225	3	a	a	DET
dti-1306	225	4	myelin	myelin	NOUN
dti-1306	225	5	-	-	PUNCT
dti-1306	225	6	related	relate	VERB
dti-1306	225	7	gene	gene	NOUN
dti-1306	225	8	located	locate	VERB
dti-1306	225	9	in	in	ADP
dti-1306	225	10	the	the	DET
dti-1306	225	11	critical	critical	ADJ
dti-1306	225	12	19q13.3	19q13.3	NUM
dti-1306	225	13	region	region	NOUN
dti-1306	225	14	,	,	PUNCT
dti-1306	225	15	is	be	AUX
dti-1306	225	16	epigenetically	epigenetically	ADV
dti-1306	225	17	silenced	silence	VERB
dti-1306	225	18	and	and	CCONJ
dti-1306	225	19	exhibits	exhibit	VERB
dti-1306	225	20	features	feature	NOUN
dti-1306	225	21	of	of	ADP
dti-1306	225	22	a	a	DET
dti-1306	225	23	candidate	candidate	NOUN
dti-1306	225	24	tumor	tumor	NOUN
dti-1306	225	25	suppressor	suppressor	NOUN
dti-1306	225	26	in	in	ADP
dti-1306	225	27	glioma	glioma	NOUN
dti-1306	225	28	and	and	CCONJ
dti-1306	225	29	neuroblastoma	neuroblastoma	NOUN
dti-1306	225	30	.	.	PUNCT
dti-1306	226	1	cancer	cancer	NOUN
dti-1306	226	2	res	re	NOUN
dti-1306	226	3	.	.	PUNCT
dti-1306	226	4	,	,	PUNCT
dti-1306	226	5	65:2565–71	65:2565–71	NOUN
dti-1306	226	6	.	.	PUNCT
dti-1306	227	1	bachman	bachman	PROPN
dti-1306	227	2	,	,	PUNCT
dti-1306	227	3	k.e	k.e	PROPN
dti-1306	227	4	.	.	PROPN
dti-1306	227	5	et	et	PROPN
dti-1306	227	6	al	al	PROPN
dti-1306	227	7	.	.	PROPN
dti-1306	227	8	1999	1999	NUM
dti-1306	227	9	.	.	PUNCT
dti-1306	228	1	methylation	methylation	NOUN
dti-1306	228	2	-	-	PUNCT
dti-1306	228	3	associated	associate	VERB
dti-1306	228	4	silencing	silencing	NOUN
dti-1306	228	5	of	of	ADP
dti-1306	228	6	the	the	DET
dti-1306	228	7	tissue	tissue	NOUN
dti-1306	228	8	inhibitor	inhibitor	NOUN
dti-1306	228	9	of	of	ADP
dti-1306	228	10	metalloproteinase-3	metalloproteinase-3	NUM
dti-1306	228	11	gene	gene	NOUN
dti-1306	228	12	suggest	suggest	VERB
dti-1306	228	13	a	a	DET
dti-1306	228	14	suppressor	suppressor	NOUN
dti-1306	228	15	role	role	NOUN
dti-1306	228	16	in	in	ADP
dti-1306	228	17	kidney	kidney	NOUN
dti-1306	228	18	,	,	PUNCT
dti-1306	228	19	brain	brain	NOUN
dti-1306	228	20	,	,	PUNCT
dti-1306	228	21	and	and	CCONJ
dti-1306	228	22	other	other	ADJ
dti-1306	228	23	human	human	ADJ
dti-1306	228	24	cancers	cancer	NOUN
dti-1306	228	25	.	.	PUNCT
dti-1306	229	1	cancer	cancer	NOUN
dti-1306	229	2	res	re	NOUN
dti-1306	229	3	.	.	PUNCT
dti-1306	229	4	,	,	PUNCT
dti-1306	229	5	59:798–802	59:798–802	PROPN
dti-1306	229	6	.	.	PUNCT
dti-1306	230	1	balana	balana	PROPN
dti-1306	230	2	,	,	PUNCT
dti-1306	230	3	c.et	c.et	PROPN
dti-1306	230	4	al	al	PROPN
dti-1306	230	5	.	.	PROPN
dti-1306	230	6	2004	2004	NUM
dti-1306	230	7	.	.	PUNCT
dti-1306	231	1	phase	phase	NOUN
dti-1306	231	2	ii	ii	PROPN
dti-1306	231	3	study	study	NOUN
dti-1306	231	4	of	of	ADP
dti-1306	231	5	temozolomide	temozolomide	NOUN
dti-1306	231	6	and	and	CCONJ
dti-1306	231	7	cisplatin	cisplatin	NOUN
dti-1306	231	8	as	as	ADP
dti-1306	231	9	primary	primary	ADJ
dti-1306	231	10	treatment	treatment	NOUN
dti-1306	231	11	prior	prior	ADV
dti-1306	231	12	to	to	ADP
dti-1306	231	13	radiotherapy	radiotherapy	NOUN
dti-1306	231	14	in	in	ADP
dti-1306	231	15	newly	newly	ADV
dti-1306	231	16	diagnosed	diagnose	VERB
dti-1306	231	17	glioblastoma	glioblastoma	NOUN
dti-1306	231	18	multiforme	multiforme	NOUN
dti-1306	231	19	patients	patient	NOUN
dti-1306	231	20	with	with	ADP
dti-1306	231	21	measurable	measurable	ADJ
dti-1306	231	22	disease	disease	NOUN
dti-1306	231	23	.	.	PUNCT
dti-1306	232	1	a	a	DET
dti-1306	232	2	study	study	NOUN
dti-1306	232	3	of	of	ADP
dti-1306	232	4	the	the	DET
dti-1306	232	5	spanish	spanish	ADJ
dti-1306	232	6	medical	medical	ADJ
dti-1306	232	7	neuro	neuro	PROPN
dti-1306	232	8	-	-	PUNCT
dti-1306	232	9	oncology	oncology	NOUN
dti-1306	232	10	group	group	NOUN
dti-1306	232	11	(	(	PUNCT
dti-1306	232	12	genom	genom	PROPN
dti-1306	232	13	)	)	PUNCT
dti-1306	232	14	.	.	PUNCT
dti-1306	233	1	j.	j.	PROPN
dti-1306	233	2	neurooncol	neurooncol	PROPN
dti-1306	233	3	.	.	PROPN
dti-1306	233	4	,	,	PUNCT
dti-1306	233	5	70:359–69	70:359–69	PROPN
dti-1306	233	6	.	.	PUNCT
dti-1306	234	1	bartel	bartel	PROPN
dti-1306	234	2	,	,	PUNCT
dti-1306	234	3	b.	b.	PROPN
dti-1306	234	4	and	and	CCONJ
dti-1306	234	5	bartel	bartel	PROPN
dti-1306	234	6	,	,	PUNCT
dti-1306	234	7	d.p	d.p	PROPN
dti-1306	234	8	.	.	PROPN
dti-1306	234	9	2003	2003	NUM
dti-1306	234	10	.	.	PUNCT
dti-1306	235	1	micrornas	microrna	NOUN
dti-1306	235	2	:	:	PUNCT
dti-1306	235	3	at	at	ADP
dti-1306	235	4	the	the	DET
dti-1306	235	5	root	root	NOUN
dti-1306	235	6	of	of	ADP
dti-1306	235	7	plant	plant	NOUN
dti-1306	235	8	development	development	NOUN
dti-1306	235	9	?	?	PUNCT
dti-1306	236	1	plant	plant	NOUN
dti-1306	236	2	physiol	physiol	PROPN
dti-1306	236	3	.	.	PUNCT
dti-1306	237	1	,	,	PUNCT
dti-1306	238	1	132:709–17	132:709–17	NUM
dti-1306	238	2	.	.	PUNCT
dti-1306	239	1	bartel	bartel	PROPN
dti-1306	239	2	,	,	PUNCT
dti-1306	239	3	d.p	d.p	PROPN
dti-1306	239	4	.	.	PROPN
dti-1306	239	5	2004	2004	NUM
dti-1306	239	6	.	.	PUNCT
dti-1306	240	1	micrornas	microrna	NOUN
dti-1306	240	2	:	:	PUNCT
dti-1306	240	3	genomics	genomic	NOUN
dti-1306	240	4	,	,	PUNCT
dti-1306	240	5	biogenesis	biogenesis	NOUN
dti-1306	240	6	,	,	PUNCT
dti-1306	240	7	mechanism	mechanism	NOUN
dti-1306	240	8	,	,	PUNCT
dti-1306	240	9	and	and	CCONJ
dti-1306	240	10	function	function	NOUN
dti-1306	240	11	.	.	PUNCT
dti-1306	241	1	cell	cell	NOUN
dti-1306	241	2	,	,	PUNCT
dti-1306	241	3	116:281–97	116:281–97	NUM
dti-1306	241	4	.	.	PUNCT
dti-1306	242	1	baumann	baumann	PROPN
dti-1306	242	2	,	,	PUNCT
dti-1306	242	3	f.	f.	PROPN
dti-1306	242	4	et	et	PROPN
dti-1306	242	5	al	al	PROPN
dti-1306	242	6	.	.	PROPN
dti-1306	242	7	2004	2004	NUM
dti-1306	242	8	.	.	PUNCT
dti-1306	243	1	combined	combine	VERB
dti-1306	243	2	thalidomide	thalidomide	NOUN
dti-1306	243	3	and	and	CCONJ
dti-1306	243	4	temozolomide	temozolomide	NOUN
dti-1306	243	5	treatment	treatment	NOUN
dti-1306	243	6	in	in	ADP
dti-1306	243	7	patients	patient	NOUN
dti-1306	243	8	with	with	ADP
dti-1306	243	9	glioblastoma	glioblastoma	NOUN
dti-1306	243	10	multiforme	multiforme	NOUN
dti-1306	243	11	.	.	PUNCT
dti-1306	244	1	j.	j.	PROPN
dti-1306	244	2	neurooncol	neurooncol	PROPN
dti-1306	244	3	.	.	PUNCT
dti-1306	244	4	,	,	PUNCT
dti-1306	245	1	67:191–200	67:191–200	NUM
dti-1306	245	2	.	.	PUNCT
dti-1306	246	1	baylin	baylin	PROPN
dti-1306	246	2	,	,	PUNCT
dti-1306	246	3	s.b	s.b	PROPN
dti-1306	246	4	.	.	PROPN
dti-1306	246	5	et	et	PROPN
dti-1306	246	6	al	al	PROPN
dti-1306	246	7	.	.	PROPN
dti-1306	246	8	2001	2001	NUM
dti-1306	246	9	.	.	PUNCT
dti-1306	247	1	aberrant	aberrant	ADJ
dti-1306	247	2	patterns	pattern	NOUN
dti-1306	247	3	of	of	ADP
dti-1306	247	4	dna	dna	PROPN
dti-1306	247	5	methylation	methylation	NOUN
dti-1306	247	6	,	,	PUNCT
dti-1306	247	7	chromatin	chromatin	NOUN
dti-1306	247	8	formation	formation	NOUN
dti-1306	247	9	and	and	CCONJ
dti-1306	247	10	gene	gene	NOUN
dti-1306	247	11	expression	expression	NOUN
dti-1306	247	12	in	in	ADP
dti-1306	247	13	cancer	cancer	NOUN
dti-1306	247	14	.	.	PUNCT
dti-1306	248	1	hum	hum	PROPN
dti-1306	248	2	.	.	PUNCT
dti-1306	249	1	mol	mol	PROPN
dti-1306	249	2	.	.	PUNCT
dti-1306	250	1	genet	genet	PROPN
dti-1306	250	2	.	.	PUNCT
dti-1306	251	1	,	,	PUNCT
dti-1306	251	2	10:687–92	10:687–92	PROPN
dti-1306	251	3	.	.	PUNCT
dti-1306	252	1	bernsen	bernsen	PROPN
dti-1306	252	2	,	,	PUNCT
dti-1306	252	3	h.j	h.j	PROPN
dti-1306	252	4	.	.	PROPN
dti-1306	252	5	and	and	CCONJ
dti-1306	252	6	van	van	PROPN
dti-1306	252	7	der	der	PROPN
dti-1306	252	8	kogel	kogel	NOUN
dti-1306	252	9	,	,	PUNCT
dti-1306	252	10	a.j	a.j	PROPN
dti-1306	252	11	.	.	PROPN
dti-1306	252	12	1999	1999	NUM
dti-1306	252	13	.	.	PUNCT
dti-1306	253	1	antiangiogenic	antiangiogenic	ADJ
dti-1306	253	2	therapy	therapy	NOUN
dti-1306	253	3	in	in	ADP
dti-1306	253	4	brain	brain	NOUN
dti-1306	253	5	tumor	tumor	NOUN
dti-1306	253	6	models	model	NOUN
dti-1306	253	7	.	.	PUNCT
dti-1306	254	1	j.	j.	PROPN
dti-1306	254	2	neurooncol	neurooncol	PROPN
dti-1306	254	3	.	.	PROPN
dti-1306	254	4	,	,	PUNCT
dti-1306	254	5	45:247–55	45:247–55	PROPN
dti-1306	254	6	.	.	PUNCT
dti-1306	255	1	bergers	berger	NOUN
dti-1306	255	2	,	,	PUNCT
dti-1306	255	3	g.	g.	PROPN
dti-1306	255	4	et	et	PROPN
dti-1306	255	5	al	al	PROPN
dti-1306	255	6	.	.	PROPN
dti-1306	255	7	2003	2003	NUM
dti-1306	255	8	.	.	PUNCT
dti-1306	256	1	benefi	benefi	PROPN
dti-1306	256	2	ts	ts	ADP
dti-1306	256	3	of	of	ADP
dti-1306	256	4	targeting	target	VERB
dti-1306	256	5	both	both	DET
dti-1306	256	6	pericytes	pericyte	NOUN
dti-1306	256	7	and	and	CCONJ
dti-1306	256	8	endothelial	endothelial	NOUN
dti-1306	256	9	cells	cell	NOUN
dti-1306	256	10	in	in	ADP
dti-1306	256	11	the	the	DET
dti-1306	256	12	tumor	tumor	NOUN
dti-1306	256	13	vasculature	vasculature	NOUN
dti-1306	256	14	with	with	ADP
dti-1306	256	15	kinase	kinase	PROPN
dti-1306	256	16	inhibitors	inhibitor	NOUN
dti-1306	256	17	.	.	PUNCT
dti-1306	257	1	j.	j.	PROPN
dti-1306	257	2	clin	clin	PROPN
dti-1306	257	3	.	.	PUNCT
dti-1306	258	1	invest	invest	PROPN
dti-1306	258	2	.	.	PUNCT
dti-1306	258	3	,	,	PUNCT
dti-1306	259	1	111:1287–95	111:1287–95	X
dti-1306	259	2	.	.	PUNCT
dti-1306	260	1	belinsky	belinsky	PROPN
dti-1306	260	2	,	,	PUNCT
dti-1306	260	3	s.a	s.a	PROPN
dti-1306	260	4	.	.	PROPN
dti-1306	260	5	et	et	PROPN
dti-1306	260	6	al	al	PROPN
dti-1306	260	7	.	.	PROPN
dti-1306	260	8	2006	2006	NUM
dti-1306	260	9	.	.	PUNCT
dti-1306	261	1	promoter	promoter	NOUN
dti-1306	261	2	hypermethylation	hypermethylation	NOUN
dti-1306	261	3	of	of	ADP
dti-1306	261	4	multiple	multiple	ADJ
dti-1306	261	5	genes	gene	NOUN
dti-1306	261	6	in	in	ADP
dti-1306	261	7	sputum	sputum	PROPN
dti-1306	261	8	precedes	precede	VERB
dti-1306	261	9	lung	lung	NOUN
dti-1306	261	10	cancer	cancer	NOUN
dti-1306	261	11	incidence	incidence	NOUN
dti-1306	261	12	in	in	ADP
dti-1306	261	13	a	a	DET
dti-1306	261	14	high	high	ADJ
dti-1306	261	15	-	-	PUNCT
dti-1306	261	16	risk	risk	NOUN
dti-1306	261	17	cohort	cohort	NOUN
dti-1306	261	18	.	.	PUNCT
dti-1306	262	1	cancer	cancer	NOUN
dti-1306	262	2	res	re	NOUN
dti-1306	262	3	.	.	PUNCT
dti-1306	262	4	,	,	PUNCT
dti-1306	262	5	66:3338–44	66:3338–44	X
dti-1306	262	6	.	.	PUNCT
dti-1306	263	1	black	black	ADJ
dti-1306	263	2	,	,	PUNCT
dti-1306	263	3	k.l	k.l	PROPN
dti-1306	263	4	.	.	PROPN
dti-1306	263	5	and	and	CCONJ
dti-1306	263	6	ningaraj	ningaraj	PROPN
dti-1306	263	7	,	,	PUNCT
dti-1306	263	8	n.s	n.s	PROPN
dti-1306	263	9	.	.	PROPN
dti-1306	263	10	2004	2004	NUM
dti-1306	263	11	.	.	PUNCT
dti-1306	264	1	modulation	modulation	NOUN
dti-1306	264	2	of	of	ADP
dti-1306	264	3	brain	brain	NOUN
dti-1306	264	4	tumor	tumor	NOUN
dti-1306	264	5	capillaries	capillary	NOUN
dti-1306	264	6	for	for	ADP
dti-1306	264	7	enhanced	enhanced	ADJ
dti-1306	264	8	drug	drug	NOUN
dti-1306	264	9	delivery	delivery	NOUN
dti-1306	264	10	selectively	selectively	ADV
dti-1306	264	11	to	to	ADP
dti-1306	264	12	brain	brain	NOUN
dti-1306	264	13	tumor	tumor	NOUN
dti-1306	264	14	.	.	PUNCT
dti-1306	265	1	cancer	cancer	NOUN
dti-1306	265	2	control	control	NOUN
dti-1306	265	3	,	,	PUNCT
dti-1306	265	4	11:165–73	11:165–73	PROPN
dti-1306	265	5	.	.	PUNCT
dti-1306	266	1	bocangel	bocangel	NOUN
dti-1306	266	2	,	,	PUNCT
dti-1306	266	3	d.b	d.b	PROPN
dti-1306	266	4	.	.	PROPN
dti-1306	266	5	et	et	PROPN
dti-1306	266	6	al	al	PROPN
dti-1306	266	7	.	.	PROPN
dti-1306	266	8	2002	2002	NUM
dti-1306	266	9	.	.	PUNCT
dti-1306	267	1	multifaceted	multifaceted	ADJ
dti-1306	267	2	resistance	resistance	NOUN
dti-1306	267	3	of	of	ADP
dti-1306	267	4	gliomas	glioma	NOUN
dti-1306	267	5	to	to	PART
dti-1306	267	6	temozolomide	temozolomide	VERB
dti-1306	267	7	.	.	PUNCT
dti-1306	268	1	clin	clin	PROPN
dti-1306	268	2	.	.	PUNCT
dti-1306	269	1	cancer	cancer	NOUN
dti-1306	269	2	res	re	NOUN
dti-1306	269	3	.	.	PROPN
dti-1306	269	4	,	,	PUNCT
dti-1306	269	5	8:2725–34	8:2725–34	NUM
dti-1306	269	6	.	.	PUNCT
dti-1306	270	1	butowski	butowski	PROPN
dti-1306	270	2	,	,	PUNCT
dti-1306	270	3	n.	n.	PROPN
dti-1306	270	4	and	and	CCONJ
dti-1306	270	5	chang	chang	PROPN
dti-1306	270	6	,	,	PUNCT
dti-1306	270	7	s.m	s.m	PROPN
dti-1306	270	8	.	.	PROPN
dti-1306	270	9	2005	2005	NUM
dti-1306	270	10	.	.	PUNCT
dti-1306	271	1	small	small	ADJ
dti-1306	271	2	molecule	molecule	NOUN
dti-1306	271	3	and	and	CCONJ
dti-1306	271	4	monoclonal	monoclonal	NOUN
dti-1306	271	5	antibody	antibody	NOUN
dti-1306	271	6	therapies	therapy	NOUN
dti-1306	271	7	in	in	ADP
dti-1306	271	8	neurooncology	neurooncology	NOUN
dti-1306	271	9	.	.	PUNCT
dti-1306	272	1	cancer	cancer	NOUN
dti-1306	272	2	control	control	PROPN
dti-1306	272	3	,	,	PUNCT
dti-1306	272	4	12:116–24	12:116–24	PROPN
dti-1306	272	5	.	.	PUNCT
dti-1306	273	1	cameron	cameron	PROPN
dti-1306	273	2	,	,	PUNCT
dti-1306	273	3	e.e	e.e	PROPN
dti-1306	273	4	.	.	PROPN
dti-1306	273	5	et	et	PROPN
dti-1306	273	6	al	al	PROPN
dti-1306	273	7	.	.	PROPN
dti-1306	273	8	1999	1999	NUM
dti-1306	273	9	.	.	PUNCT
dti-1306	274	1	synergy	synergy	NOUN
dti-1306	274	2	of	of	ADP
dti-1306	274	3	demethylation	demethylation	NOUN
dti-1306	274	4	and	and	CCONJ
dti-1306	274	5	histone	histone	NOUN
dti-1306	274	6	deacetylase	deacetylase	NOUN
dti-1306	274	7	inhibition	inhibition	NOUN
dti-1306	274	8	in	in	ADP
dti-1306	274	9	the	the	DET
dti-1306	274	10	re	re	NOUN
dti-1306	274	11	-	-	NOUN
dti-1306	274	12	expression	expression	NOUN
dti-1306	274	13	of	of	ADP
dti-1306	274	14	genes	gene	NOUN
dti-1306	274	15	silenced	silence	VERB
dti-1306	274	16	in	in	ADP
dti-1306	274	17	cancer	cancer	NOUN
dti-1306	274	18	.	.	PUNCT
dti-1306	275	1	nat	nat	PROPN
dti-1306	275	2	.	.	PUNCT
dti-1306	276	1	genet	genet	PROPN
dti-1306	276	2	.	.	PUNCT
dti-1306	276	3	,	,	PUNCT
dti-1306	276	4	21:103–7	21:103–7	NUM
dti-1306	276	5	.	.	PUNCT
dti-1306	277	1	cairns	cairns	PROPN
dti-1306	277	2	,	,	PUNCT
dti-1306	277	3	p.	p.	NOUN
dti-1306	277	4	et	et	NOUN
dti-1306	278	1	al	al	PROPN
dti-1306	278	2	.	.	PROPN
dti-1306	278	3	2001	2001	NUM
dti-1306	278	4	.	.	PUNCT
dti-1306	279	1	molecular	molecular	ADJ
dti-1306	279	2	detection	detection	NOUN
dti-1306	279	3	of	of	ADP
dti-1306	279	4	prostate	prostate	NOUN
dti-1306	279	5	cancer	cancer	NOUN
dti-1306	279	6	in	in	ADP
dti-1306	279	7	urine	urine	NOUN
dti-1306	279	8	by	by	ADP
dti-1306	279	9	gstp1	gstp1	NOUN
dti-1306	279	10	hypermethylation	hypermethylation	NOUN
dti-1306	279	11	.	.	PUNCT
dti-1306	280	1	clin	clin	PROPN
dti-1306	280	2	.	.	PUNCT
dti-1306	281	1	cancer	cancer	NOUN
dti-1306	281	2	res	re	NOUN
dti-1306	281	3	.	.	PROPN
dti-1306	281	4	,	,	PUNCT
dti-1306	281	5	7:2727–30	7:2727–30	NUM
dti-1306	281	6	.	.	PUNCT
dti-1306	282	1	calin	calin	PROPN
dti-1306	282	2	,	,	PUNCT
dti-1306	282	3	g.a	g.a	PROPN
dti-1306	282	4	.	.	PROPN
dti-1306	282	5	and	and	CCONJ
dti-1306	282	6	croce	croce	PROPN
dti-1306	282	7	,	,	PUNCT
dti-1306	282	8	c.m	c.m	PROPN
dti-1306	282	9	.	.	PROPN
dti-1306	282	10	2006a	2006a	NOUN
dti-1306	282	11	.	.	PUNCT
dti-1306	283	1	genomics	genomic	NOUN
dti-1306	283	2	of	of	ADP
dti-1306	283	3	chronic	chronic	ADJ
dti-1306	283	4	lymphocytic	lymphocytic	ADJ
dti-1306	283	5	leukemia	leukemia	NOUN
dti-1306	283	6	micrornas	microrna	NOUN
dti-1306	283	7	as	as	ADP
dti-1306	283	8	new	new	ADJ
dti-1306	283	9	players	player	NOUN
dti-1306	283	10	with	with	ADP
dti-1306	283	11	clinical	clinical	ADJ
dti-1306	283	12	signifi	signifi	NOUN
dti-1306	283	13	cance	cance	PROPN
dti-1306	283	14	.	.	PUNCT
dti-1306	284	1	semin	semin	PROPN
dti-1306	284	2	.	.	PUNCT
dti-1306	285	1	oncol	oncol	PROPN
dti-1306	285	2	.	.	PUNCT
dti-1306	285	3	,	,	PUNCT
dti-1306	285	4	33:167–73	33:167–73	PROPN
dti-1306	285	5	.	.	PUNCT
dti-1306	286	1	calin	calin	PROPN
dti-1306	286	2	,	,	PUNCT
dti-1306	286	3	g.a	g.a	PROPN
dti-1306	286	4	.	.	PROPN
dti-1306	286	5	and	and	CCONJ
dti-1306	286	6	croce	croce	PROPN
dti-1306	286	7	,	,	PUNCT
dti-1306	286	8	c.m	c.m	PROPN
dti-1306	286	9	.	.	PROPN
dti-1306	286	10	2006b	2006b	NUM
dti-1306	286	11	.	.	PUNCT
dti-1306	287	1	micrornas	microrna	NOUN
dti-1306	287	2	and	and	CCONJ
dti-1306	287	3	chromosomal	chromosomal	ADJ
dti-1306	287	4	abnormalities	abnormality	NOUN
dti-1306	287	5	in	in	ADP
dti-1306	287	6	cancer	cancer	NOUN
dti-1306	287	7	cells	cell	NOUN
dti-1306	287	8	.	.	PUNCT
dti-1306	288	1	oncogene	oncogene	NOUN
dti-1306	288	2	,	,	PUNCT
dti-1306	288	3	25:6202–10	25:6202–10	NUM
dti-1306	288	4	.	.	PUNCT
dti-1306	289	1	chan	chan	PROPN
dti-1306	289	2	,	,	PUNCT
dti-1306	289	3	j.a	j.a	PROPN
dti-1306	289	4	.	.	PROPN
dti-1306	289	5	,	,	PUNCT
dti-1306	289	6	krichevsky	krichevsky	PROPN
dti-1306	289	7	,	,	PUNCT
dti-1306	289	8	a.m.	a.m.	PROPN
dti-1306	289	9	and	and	CCONJ
dti-1306	289	10	kosik	kosik	PROPN
dti-1306	289	11	,	,	PUNCT
dti-1306	289	12	k.s	k.s	PROPN
dti-1306	289	13	.	.	PROPN
dti-1306	289	14	2005	2005	NUM
dti-1306	289	15	.	.	PUNCT
dti-1306	290	1	microrna-21	microrna-21	PROPN
dti-1306	290	2	is	be	AUX
dti-1306	290	3	an	an	DET
dti-1306	290	4	antiapoptotic	antiapoptotic	ADJ
dti-1306	290	5	factor	factor	NOUN
dti-1306	290	6	in	in	ADP
dti-1306	290	7	human	human	ADJ
dti-1306	290	8	glioblastoma	glioblastoma	NOUN
dti-1306	290	9	cells	cell	NOUN
dti-1306	290	10	.	.	PUNCT
dti-1306	291	1	cancer	cancer	NOUN
dti-1306	291	2	res	re	NOUN
dti-1306	291	3	.	.	PROPN
dti-1306	291	4	,	,	PUNCT
dti-1306	291	5	65:6029–33	65:6029–33	NUM
dti-1306	291	6	.	.	PUNCT
dti-1306	292	1	ciafre	ciafre	PROPN
dti-1306	292	2	,	,	PUNCT
dti-1306	292	3	s.a	s.a	PROPN
dti-1306	292	4	.	.	PROPN
dti-1306	292	5	et	et	PROPN
dti-1306	292	6	al	al	PROPN
dti-1306	292	7	.	.	PROPN
dti-1306	292	8	2005	2005	NUM
dti-1306	292	9	.	.	PUNCT
dti-1306	293	1	extensive	extensive	ADJ
dti-1306	293	2	modulation	modulation	NOUN
dti-1306	293	3	of	of	ADP
dti-1306	293	4	a	a	DET
dti-1306	293	5	set	set	NOUN
dti-1306	293	6	of	of	ADP
dti-1306	293	7	micrornas	microrna	NOUN
dti-1306	293	8	in	in	ADP
dti-1306	293	9	primary	primary	ADJ
dti-1306	293	10	glioblastoma	glioblastoma	NOUN
dti-1306	293	11	.	.	PUNCT
dti-1306	294	1	biochem	biochem	PROPN
dti-1306	294	2	.	.	PUNCT
dti-1306	295	1	biophys	biophy	NOUN
dti-1306	295	2	.	.	PUNCT
dti-1306	296	1	res	re	NOUN
dti-1306	296	2	.	.	PUNCT
dti-1306	297	1	commun	commun	PROPN
dti-1306	297	2	.	.	PROPN
dti-1306	297	3	,	,	PUNCT
dti-1306	297	4	334:1351–8	334:1351–8	NUM
dti-1306	297	5	.	.	PUNCT
dti-1306	298	1	costello	costello	PROPN
dti-1306	298	2	,	,	PUNCT
dti-1306	298	3	j.f	j.f	PROPN
dti-1306	298	4	.	.	PROPN
dti-1306	298	5	et	et	PROPN
dti-1306	298	6	al	al	PROPN
dti-1306	298	7	.	.	PROPN
dti-1306	298	8	1996	1996	NUM
dti-1306	298	9	.	.	PUNCT
dti-1306	299	1	silencing	silence	VERB
dti-1306	299	2	of	of	ADP
dti-1306	299	3	p16	p16	NOUN
dti-1306	299	4	/	/	SYM
dti-1306	299	5	cdkn2	cdkn2	NOUN
dti-1306	299	6	expression	expression	NOUN
dti-1306	299	7	in	in	ADP
dti-1306	299	8	human	human	ADJ
dti-1306	299	9	gliomas	glioma	NOUN
dti-1306	299	10	by	by	ADP
dti-1306	299	11	methylation	methylation	NOUN
dti-1306	299	12	and	and	CCONJ
dti-1306	299	13	chromatin	chromatin	NOUN
dti-1306	299	14	condensation	condensation	NOUN
dti-1306	299	15	.	.	PUNCT
dti-1306	300	1	cancer	cancer	NOUN
dti-1306	300	2	res	re	NOUN
dti-1306	300	3	.	.	PUNCT
dti-1306	300	4	,	,	PUNCT
dti-1306	301	1	56:2405–10	56:2405–10	X
dti-1306	301	2	.	.	PUNCT
dti-1306	302	1	costello	costello	PROPN
dti-1306	302	2	,	,	PUNCT
dti-1306	302	3	j.f	j.f	PROPN
dti-1306	302	4	.	.	PROPN
dti-1306	302	5	et	et	PROPN
dti-1306	302	6	al	al	PROPN
dti-1306	302	7	.	.	PROPN
dti-1306	302	8	2000	2000	NUM
dti-1306	302	9	.	.	PUNCT
dti-1306	303	1	aberrant	aberrant	ADJ
dti-1306	303	2	cpg	cpg	PROPN
dti-1306	303	3	-	-	PUNCT
dti-1306	303	4	island	island	NOUN
dti-1306	303	5	methylation	methylation	NOUN
dti-1306	303	6	has	have	VERB
dti-1306	303	7	non	non	ADJ
dti-1306	303	8	-	-	ADJ
dti-1306	303	9	random	random	ADJ
dti-1306	303	10	and	and	CCONJ
dti-1306	303	11	tumour	tumour	NOUN
dti-1306	303	12	-	-	PUNCT
dti-1306	303	13	type	type	NOUN
dti-1306	303	14	-	-	PUNCT
dti-1306	303	15	specifi	specifi	NOUN
dti-1306	303	16	c	c	PROPN
dti-1306	303	17	patterns	pattern	NOUN
dti-1306	303	18	.	.	PUNCT
dti-1306	304	1	nat	nat	PROPN
dti-1306	304	2	.	.	PUNCT
dti-1306	305	1	genet	genet	PROPN
dti-1306	305	2	.	.	PUNCT
dti-1306	305	3	,	,	PUNCT
dti-1306	305	4	24:132–8	24:132–8	NUM
dti-1306	305	5	.	.	X
dti-1306	305	6	206	206	NUM
dti-1306	305	7	ningaraj	ningaraj	ADJ
dti-1306	305	8	et	et	PROPN
dti-1306	305	9	al	al	PROPN
dti-1306	305	10	drug	drug	PROPN
dti-1306	305	11	target	target	NOUN
dti-1306	305	12	insights	insight	NOUN
dti-1306	305	13	2007	2007	NUM
dti-1306	305	14	:	:	PUNCT
dti-1306	305	15	2	2	NUM
dti-1306	305	16	costello	costello	PROPN
dti-1306	305	17	,	,	PUNCT
dti-1306	305	18	j.f	j.f	PROPN
dti-1306	305	19	.	.	PROPN
dti-1306	305	20	2003	2003	NUM
dti-1306	305	21	.	.	PUNCT
dti-1306	306	1	dna	dna	PROPN
dti-1306	306	2	methylation	methylation	NOUN
dti-1306	306	3	in	in	ADP
dti-1306	306	4	brain	brain	NOUN
dti-1306	306	5	development	development	NOUN
dti-1306	306	6	and	and	CCONJ
dti-1306	306	7	gliomagenesis	gliomagenesis	NOUN
dti-1306	306	8	.	.	PUNCT
dti-1306	307	1	front	front	PROPN
dti-1306	307	2	biosci	biosci	PROPN
dti-1306	307	3	.	.	PUNCT
dti-1306	307	4	,	,	PUNCT
dti-1306	307	5	8	8	NUM
dti-1306	307	6	:	:	PUNCT
dti-1306	307	7	s175–84	s175–84	NOUN
dti-1306	307	8	.	.	PUNCT
dti-1306	308	1	dalmay	dalmay	PROPN
dti-1306	308	2	,	,	PUNCT
dti-1306	308	3	t.	t.	PROPN
dti-1306	308	4	and	and	CCONJ
dti-1306	308	5	edwards	edwards	PROPN
dti-1306	308	6	,	,	PUNCT
dti-1306	308	7	d.r	d.r	PROPN
dti-1306	308	8	.	.	PROPN
dti-1306	308	9	2006	2006	NUM
dti-1306	308	10	.	.	PUNCT
dti-1306	309	1	micrornas	microrna	NOUN
dti-1306	309	2	and	and	CCONJ
dti-1306	309	3	the	the	DET
dti-1306	309	4	hallmarks	hallmark	NOUN
dti-1306	309	5	of	of	ADP
dti-1306	309	6	cancer	cancer	NOUN
dti-1306	309	7	.	.	PUNCT
dti-1306	310	1	oncogene	oncogene	NOUN
dti-1306	310	2	,	,	PUNCT
dti-1306	310	3	25:6170–5	25:6170–5	NUM
dti-1306	310	4	.	.	PUNCT
dti-1306	311	1	daskalakis	daskalaki	NOUN
dti-1306	311	2	,	,	PUNCT
dti-1306	311	3	m.	m.	NOUN
dti-1306	311	4	et	et	PROPN
dti-1306	311	5	al	al	PROPN
dti-1306	311	6	.	.	PROPN
dti-1306	311	7	2002	2002	NUM
dti-1306	311	8	.	.	PUNCT
dti-1306	312	1	demethylation	demethylation	NOUN
dti-1306	312	2	of	of	ADP
dti-1306	312	3	a	a	DET
dti-1306	312	4	hypermethylated	hypermethylate	VERB
dti-1306	312	5	p15	p15	ADJ
dti-1306	312	6	/	/	SYM
dti-1306	312	7	ink4b	ink4b	PROPN
dti-1306	312	8	gene	gene	NOUN
dti-1306	312	9	in	in	ADP
dti-1306	312	10	patients	patient	NOUN
dti-1306	312	11	with	with	ADP
dti-1306	312	12	myelodysplastic	myelodysplastic	ADJ
dti-1306	312	13	syndrome	syndrome	NOUN
dti-1306	312	14	by	by	ADP
dti-1306	312	15	5	5	NUM
dti-1306	312	16	-	-	PUNCT
dti-1306	312	17	aza-2′deoxycytidine	aza-2′deoxycytidine	NOUN
dti-1306	312	18	(	(	PUNCT
dti-1306	312	19	decitabine	decitabine	NOUN
dti-1306	312	20	)	)	PUNCT
dti-1306	312	21	treatment	treatment	NOUN
dti-1306	312	22	.	.	PUNCT
dti-1306	313	1	blood	blood	NOUN
dti-1306	313	2	,	,	PUNCT
dti-1306	313	3	100:2957–64	100:2957–64	PROPN
dti-1306	313	4	.	.	PROPN
dti-1306	313	5	fabian	fabian	PROPN
dti-1306	313	6	,	,	PUNCT
dti-1306	313	7	m.a	m.a	PROPN
dti-1306	313	8	.	.	PROPN
dti-1306	313	9	et	et	PROPN
dti-1306	313	10	al	al	PROPN
dti-1306	313	11	.	.	PROPN
dti-1306	313	12	2005	2005	NUM
dti-1306	313	13	.	.	PUNCT
dti-1306	314	1	a	a	DET
dti-1306	314	2	small	small	ADJ
dti-1306	314	3	molecule	molecule	NOUN
dti-1306	314	4	-	-	PUNCT
dti-1306	314	5	kinase	kinase	NOUN
dti-1306	314	6	interaction	interaction	NOUN
dti-1306	314	7	map	map	NOUN
dti-1306	314	8	for	for	ADP
dti-1306	314	9	clinical	clinical	ADJ
dti-1306	314	10	kinase	kinase	NOUN
dti-1306	314	11	inhibitors	inhibitor	NOUN
dti-1306	314	12	.	.	PUNCT
dti-1306	315	1	nat	nat	NOUN
dti-1306	315	2	.	.	PUNCT
dti-1306	316	1	biotechnol	biotechnol	PROPN
dti-1306	316	2	.	.	PUNCT
dti-1306	316	3	,	,	PUNCT
dti-1306	316	4	23:329–36	23:329–36	PROPN
dti-1306	316	5	.	.	PUNCT
dti-1306	317	1	forseen	forseen	PROPN
dti-1306	317	2	,	,	PUNCT
dti-1306	317	3	s.e	s.e	PROPN
dti-1306	317	4	.	.	PROPN
dti-1306	317	5	et	et	PROPN
dti-1306	317	6	al	al	PROPN
dti-1306	317	7	.	.	PROPN
dti-1306	317	8	2002	2002	NUM
dti-1306	317	9	.	.	PUNCT
dti-1306	318	1	identifi	identifi	PROPN
dti-1306	318	2	cation	cation	NOUN
dti-1306	318	3	and	and	CCONJ
dti-1306	318	4	relationship	relationship	NOUN
dti-1306	318	5	of	of	ADP
dti-1306	318	6	her-2	her-2	PRON
dti-1306	318	7	/	/	SYM
dti-1306	318	8	neu	neu	NOUN
dti-1306	318	9	overexpression	overexpression	NOUN
dti-1306	318	10	to	to	ADP
dti-1306	318	11	short	short	ADJ
dti-1306	318	12	-	-	PUNCT
dti-1306	318	13	term	term	NOUN
dti-1306	318	14	mortality	mortality	NOUN
dti-1306	318	15	in	in	ADP
dti-1306	318	16	primary	primary	ADJ
dti-1306	318	17	malignant	malignant	ADJ
dti-1306	318	18	brain	brain	NOUN
dti-1306	318	19	tumors	tumor	NOUN
dti-1306	318	20	.	.	PUNCT
dti-1306	319	1	anticancer	anticancer	NOUN
dti-1306	319	2	res	re	NOUN
dti-1306	319	3	.	.	PROPN
dti-1306	319	4	,	,	PUNCT
dti-1306	319	5	22:1599–602	22:1599–602	PROPN
dti-1306	319	6	.	.	PUNCT
dti-1306	320	1	foltz	foltz	PROPN
dti-1306	320	2	,	,	PUNCT
dti-1306	320	3	g.	g.	PROPN
dti-1306	320	4	et	et	PROPN
dti-1306	320	5	al	al	PROPN
dti-1306	320	6	.	.	PROPN
dti-1306	320	7	2006	2006	NUM
dti-1306	320	8	.	.	PUNCT
dti-1306	321	1	genome	genome	NOUN
dti-1306	321	2	-	-	PUNCT
dti-1306	321	3	wide	wide	ADJ
dti-1306	321	4	analysis	analysis	NOUN
dti-1306	321	5	of	of	ADP
dti-1306	321	6	epigenetic	epigenetic	ADJ
dti-1306	321	7	silencing	silence	VERB
dti-1306	321	8	identifi	identifi	NOUN
dti-1306	321	9	es	es	X
dti-1306	321	10	bex1	bex1	NOUN
dti-1306	321	11	and	and	CCONJ
dti-1306	321	12	bex2	bex2	NOUN
dti-1306	321	13	as	as	ADP
dti-1306	321	14	candidate	candidate	NOUN
dti-1306	321	15	tumor	tumor	NOUN
dti-1306	321	16	suppressor	suppressor	NOUN
dti-1306	321	17	genes	gene	NOUN
dti-1306	321	18	in	in	ADP
dti-1306	321	19	malignant	malignant	ADJ
dti-1306	321	20	glioma	glioma	NOUN
dti-1306	321	21	.	.	PUNCT
dti-1306	322	1	cancer	cancer	NOUN
dti-1306	322	2	res	re	NOUN
dti-1306	322	3	.	.	PUNCT
dti-1306	322	4	,	,	PUNCT
dti-1306	322	5	66:6665–74	66:6665–74	NUM
dti-1306	322	6	.	.	PUNCT
dti-1306	323	1	friedman	friedman	PROPN
dti-1306	323	2	,	,	PUNCT
dti-1306	323	3	h.s	h.s	PROPN
dti-1306	323	4	.	.	PROPN
dti-1306	323	5	,	,	PUNCT
dti-1306	323	6	kerby	kerby	PROPN
dti-1306	323	7	,	,	PUNCT
dti-1306	323	8	t.	t.	PROPN
dti-1306	323	9	and	and	CCONJ
dti-1306	323	10	calvert	calvert	PROPN
dti-1306	323	11	,	,	PUNCT
dti-1306	323	12	h.	h.	PROPN
dti-1306	323	13	2000	2000	NUM
dti-1306	323	14	.	.	PUNCT
dti-1306	324	1	temozolomide	temozolomide	NOUN
dti-1306	324	2	and	and	CCONJ
dti-1306	324	3	treatment	treatment	NOUN
dti-1306	324	4	of	of	ADP
dti-1306	324	5	malignant	malignant	ADJ
dti-1306	324	6	glioma	glioma	NOUN
dti-1306	324	7	.	.	PUNCT
dti-1306	325	1	clin	clin	PROPN
dti-1306	325	2	.	.	PUNCT
dti-1306	326	1	cancer	cancer	NOUN
dti-1306	326	2	res	re	NOUN
dti-1306	326	3	.	.	PROPN
dti-1306	326	4	,	,	PUNCT
dti-1306	326	5	6:2585–97	6:2585–97	ADJ
dti-1306	326	6	.	.	PUNCT
dti-1306	327	1	fuller	full	ADJ
dti-1306	327	2	,	,	PUNCT
dti-1306	327	3	g.n	g.n	PROPN
dti-1306	327	4	.	.	PROPN
dti-1306	327	5	and	and	CCONJ
dti-1306	327	6	bigner	bigner	NOUN
dti-1306	327	7	,	,	PUNCT
dti-1306	327	8	s.h	s.h	PROPN
dti-1306	327	9	.	.	PROPN
dti-1306	327	10	1992	1992	NUM
dti-1306	327	11	.	.	PUNCT
dti-1306	328	1	amplifi	amplifi	PROPN
dti-1306	328	2	ed	ed	NOUN
dti-1306	328	3	cellular	cellular	ADJ
dti-1306	328	4	oncogenes	oncogene	NOUN
dti-1306	328	5	in	in	ADP
dti-1306	328	6	neoplasms	neoplasm	NOUN
dti-1306	328	7	of	of	ADP
dti-1306	328	8	the	the	DET
dti-1306	328	9	human	human	ADJ
dti-1306	328	10	central	central	ADJ
dti-1306	328	11	nervous	nervous	ADJ
dti-1306	328	12	system	system	NOUN
dti-1306	328	13	.	.	PUNCT
dti-1306	329	1	mutat	mutat	PROPN
dti-1306	329	2	.	.	PUNCT
dti-1306	329	3	res	re	NOUN
dti-1306	329	4	.	.	PROPN
dti-1306	329	5	,	,	PUNCT
dti-1306	329	6	276:299–306	276:299–306	NUM
dti-1306	329	7	.	.	PUNCT
dti-1306	330	1	fueyo	fueyo	PROPN
dti-1306	330	2	,	,	PUNCT
dti-1306	330	3	j.	j.	PROPN
dti-1306	330	4	et	et	PROPN
dti-1306	330	5	al	al	PROPN
dti-1306	330	6	.	.	PROPN
dti-1306	330	7	1996	1996	NUM
dti-1306	330	8	.	.	PUNCT
dti-1306	331	1	hypermethylation	hypermethylation	NOUN
dti-1306	331	2	of	of	ADP
dti-1306	331	3	the	the	DET
dti-1306	331	4	cpg	cpg	NOUN
dti-1306	331	5	island	island	NOUN
dti-1306	331	6	of	of	ADP
dti-1306	331	7	p16	p16	NOUN
dti-1306	331	8	/	/	SYM
dti-1306	331	9	cdkn2	cdkn2	NOUN
dti-1306	331	10	correlates	correlate	VERB
dti-1306	331	11	with	with	ADP
dti-1306	331	12	gene	gene	NOUN
dti-1306	331	13	inactivation	inactivation	NOUN
dti-1306	331	14	in	in	ADP
dti-1306	331	15	gliomas	glioma	NOUN
dti-1306	331	16	.	.	PUNCT
dti-1306	332	1	oncogene	oncogene	NOUN
dti-1306	332	2	,	,	PUNCT
dti-1306	332	3	13:1615–9	13:1615–9	NUM
dti-1306	332	4	.	.	PUNCT
dti-1306	333	1	gullick	gullick	PROPN
dti-1306	333	2	,	,	PUNCT
dti-1306	333	3	w.j	w.j	PROPN
dti-1306	333	4	.	.	PROPN
dti-1306	333	5	2001	2001	NUM
dti-1306	333	6	.	.	PUNCT
dti-1306	334	1	update	update	NOUN
dti-1306	334	2	on	on	ADP
dti-1306	334	3	her-2	her-2	PRON
dti-1306	334	4	as	as	ADP
dti-1306	334	5	a	a	DET
dti-1306	334	6	target	target	NOUN
dti-1306	334	7	for	for	ADP
dti-1306	334	8	cancer	cancer	NOUN
dti-1306	334	9	therapy	therapy	NOUN
dti-1306	334	10	:	:	PUNCT
dti-1306	334	11	alternative	alternative	ADJ
dti-1306	334	12	strategies	strategy	NOUN
dti-1306	334	13	for	for	ADP
dti-1306	334	14	targeting	target	VERB
dti-1306	334	15	the	the	DET
dti-1306	334	16	epidermal	epidermal	ADJ
dti-1306	334	17	growth	growth	NOUN
dti-1306	334	18	factor	factor	NOUN
dti-1306	334	19	system	system	NOUN
dti-1306	334	20	in	in	ADP
dti-1306	334	21	cancer	cancer	NOUN
dti-1306	334	22	.	.	PUNCT
dti-1306	335	1	breast	breast	NOUN
dti-1306	335	2	cancer	cancer	NOUN
dti-1306	335	3	res	re	NOUN
dti-1306	335	4	.	.	PUNCT
dti-1306	335	5	,	,	PUNCT
dti-1306	335	6	3:390–4	3:390–4	X
dti-1306	335	7	.	.	PUNCT
dti-1306	336	1	goffi	goffi	PROPN
dti-1306	336	2	n	n	PRON
dti-1306	336	3	,	,	PUNCT
dti-1306	336	4	j.	j.	PROPN
dti-1306	336	5	and	and	CCONJ
dti-1306	336	6	eisenhauer	eisenhauer	PROPN
dti-1306	336	7	,	,	PUNCT
dti-1306	336	8	e.	e.	PROPN
dti-1306	336	9	2002	2002	NUM
dti-1306	336	10	.	.	PUNCT
dti-1306	337	1	dna	dna	PROPN
dti-1306	337	2	methyltransferase	methyltransferase	NOUN
dti-1306	337	3	inhibitors	inhibitor	NOUN
dti-1306	337	4	-	-	PUNCT
dti-1306	337	5	state	state	NOUN
dti-1306	337	6	of	of	ADP
dti-1306	337	7	the	the	DET
dti-1306	337	8	art	art	NOUN
dti-1306	337	9	.	.	PUNCT
dti-1306	338	1	ann	ann	PROPN
dti-1306	338	2	.	.	PUNCT
dti-1306	338	3	oncol	oncol	PROPN
dti-1306	338	4	.	.	PUNCT
dti-1306	338	5	,	,	PUNCT
dti-1306	339	1	13:1699–716	13:1699–716	NUM
dti-1306	339	2	.	.	PUNCT
dti-1306	339	3	gurney	gurney	NOUN
dti-1306	339	4	,	,	PUNCT
dti-1306	339	5	a.m.	a.m.	NOUN
dti-1306	339	6	and	and	CCONJ
dti-1306	339	7	hunter	hunter	NOUN
dti-1306	339	8	,	,	PUNCT
dti-1306	339	9	e.	e.	PROPN
dti-1306	339	10	2005	2005	NUM
dti-1306	339	11	.	.	PUNCT
dti-1306	340	1	the	the	DET
dti-1306	340	2	use	use	NOUN
dti-1306	340	3	of	of	ADP
dti-1306	340	4	small	small	ADJ
dti-1306	340	5	interfering	interfere	VERB
dti-1306	340	6	rna	rna	NOUN
dti-1306	340	7	to	to	PART
dti-1306	340	8	elucidate	elucidate	VERB
dti-1306	340	9	the	the	DET
dti-1306	340	10	activity	activity	NOUN
dti-1306	340	11	and	and	CCONJ
dti-1306	340	12	function	function	NOUN
dti-1306	340	13	of	of	ADP
dti-1306	340	14	ion	ion	NOUN
dti-1306	340	15	channel	channel	NOUN
dti-1306	340	16	genes	gene	NOUN
dti-1306	340	17	in	in	ADP
dti-1306	340	18	an	an	DET
dti-1306	340	19	intact	intact	ADJ
dti-1306	340	20	tissue	tissue	NOUN
dti-1306	340	21	.	.	PUNCT
dti-1306	341	1	j.	j.	PROPN
dti-1306	341	2	pharmacol	pharmacol	PROPN
dti-1306	341	3	.	.	PUNCT
dti-1306	342	1	toxicol	toxicol	PROPN
dti-1306	342	2	.	.	PUNCT
dti-1306	343	1	methods	method	NOUN
dti-1306	343	2	,	,	PUNCT
dti-1306	343	3	51:253–62	51:253–62	NUM
dti-1306	343	4	.	.	PUNCT
dti-1306	344	1	hegi	hegi	PROPN
dti-1306	344	2	,	,	PUNCT
dti-1306	344	3	m.e	m.e	PROPN
dti-1306	344	4	.	.	PROPN
dti-1306	344	5	et	et	PROPN
dti-1306	344	6	al	al	PROPN
dti-1306	344	7	.	.	PROPN
dti-1306	344	8	1997	1997	NUM
dti-1306	344	9	.	.	PUNCT
dti-1306	345	1	hemizygous	hemizygous	ADJ
dti-1306	345	2	or	or	CCONJ
dti-1306	345	3	homozygous	homozygous	ADJ
dti-1306	345	4	deletion	deletion	NOUN
dti-1306	345	5	of	of	ADP
dti-1306	345	6	the	the	DET
dti-1306	345	7	chromosomal	chromosomal	ADJ
dti-1306	345	8	region	region	NOUN
dti-1306	345	9	containing	contain	VERB
dti-1306	345	10	the	the	DET
dti-1306	345	11	p16ink4a	p16ink4a	PROPN
dti-1306	345	12	gene	gene	NOUN
dti-1306	345	13	is	be	AUX
dti-1306	345	14	associated	associate	VERB
dti-1306	345	15	with	with	ADP
dti-1306	345	16	amplifi	amplifi	NOUN
dti-1306	345	17	cation	cation	NOUN
dti-1306	345	18	of	of	ADP
dti-1306	345	19	the	the	DET
dti-1306	345	20	egf	egf	PROPN
dti-1306	345	21	receptor	receptor	NOUN
dti-1306	345	22	gene	gene	NOUN
dti-1306	345	23	in	in	ADP
dti-1306	345	24	glioblastomas	glioblastoma	NOUN
dti-1306	345	25	.	.	PUNCT
dti-1306	346	1	int	int	NOUN
dti-1306	346	2	.	.	PUNCT
dti-1306	347	1	j.	j.	PROPN
dti-1306	347	2	cancer	cancer	PROPN
dti-1306	347	3	.	.	PUNCT
dti-1306	347	4	,	,	PUNCT
dti-1306	347	5	73:57–63	73:57–63	NUM
dti-1306	347	6	.	.	PUNCT
dti-1306	348	1	hirose	hirose	NOUN
dti-1306	348	2	,	,	PUNCT
dti-1306	348	3	y.	y.	PROPN
dti-1306	348	4	berger	berger	PROPN
dti-1306	348	5	,	,	PUNCT
dti-1306	348	6	m.s	m.s	PROPN
dti-1306	348	7	.	.	PROPN
dti-1306	348	8	and	and	CCONJ
dti-1306	348	9	pieper	pieper	PROPN
dti-1306	348	10	,	,	PUNCT
dti-1306	348	11	r.o	r.o	PROPN
dti-1306	348	12	.	.	PROPN
dti-1306	348	13	2001	2001	NUM
dti-1306	348	14	.	.	PUNCT
dti-1306	349	1	p53	p53	NOUN
dti-1306	349	2	effects	effect	NOUN
dti-1306	349	3	both	both	CCONJ
dti-1306	349	4	the	the	DET
dti-1306	349	5	duration	duration	NOUN
dti-1306	349	6	of	of	ADP
dti-1306	349	7	g2	g2	PROPN
dti-1306	349	8	/	/	SYM
dti-1306	349	9	m	m	NOUN
dti-1306	349	10	arrest	arrest	NOUN
dti-1306	349	11	and	and	CCONJ
dti-1306	349	12	the	the	DET
dti-1306	349	13	fate	fate	NOUN
dti-1306	349	14	of	of	ADP
dti-1306	349	15	temozolomide	temozolomide	NOUN
dti-1306	349	16	-	-	PUNCT
dti-1306	349	17	treated	treat	VERB
dti-1306	349	18	human	human	ADJ
dti-1306	349	19	glioblastoma	glioblastoma	NOUN
dti-1306	349	20	cells	cell	NOUN
dti-1306	349	21	.	.	PUNCT
dti-1306	350	1	cancer	cancer	NOUN
dti-1306	350	2	res	re	NOUN
dti-1306	350	3	.	.	PROPN
dti-1306	350	4	,	,	PUNCT
dti-1306	350	5	61:1957–63	61:1957–63	NUM
dti-1306	350	6	.	.	PUNCT
dti-1306	351	1	hutvagner	hutvagner	NOUN
dti-1306	351	2	,	,	PUNCT
dti-1306	351	3	g.	g.	PROPN
dti-1306	351	4	2006	2006	NUM
dti-1306	351	5	.	.	PUNCT
dti-1306	352	1	micrornas	microrna	NOUN
dti-1306	352	2	and	and	CCONJ
dti-1306	352	3	cancer	cancer	NOUN
dti-1306	352	4	:	:	PUNCT
dti-1306	352	5	issue	issue	NOUN
dti-1306	352	6	summary	summary	NOUN
dti-1306	352	7	.	.	PUNCT
dti-1306	353	1	oncogene	oncogene	NOUN
dti-1306	353	2	,	,	PUNCT
dti-1306	353	3	25:6154–5	25:6154–5	NUM
dti-1306	353	4	.	.	PUNCT
dti-1306	354	1	ichimura	ichimura	PROPN
dti-1306	354	2	,	,	PUNCT
dti-1306	354	3	k.	k.	PROPN
dti-1306	354	4	et	et	PROPN
dti-1306	354	5	al	al	PROPN
dti-1306	354	6	.	.	PROPN
dti-1306	354	7	1996	1996	NUM
dti-1306	354	8	.	.	PUNCT
dti-1306	355	1	human	human	ADJ
dti-1306	355	2	glioblastomas	glioblastoma	NOUN
dti-1306	355	3	with	with	ADP
dti-1306	355	4	no	no	DET
dti-1306	355	5	alterations	alteration	NOUN
dti-1306	355	6	of	of	ADP
dti-1306	355	7	the	the	DET
dti-1306	355	8	cdkn2a	cdkn2a	PROPN
dti-1306	355	9	(	(	PUNCT
dti-1306	355	10	p16ink4a	p16ink4a	PROPN
dti-1306	355	11	,	,	PUNCT
dti-1306	355	12	mts1	mts1	PROPN
dti-1306	355	13	)	)	PUNCT
dti-1306	355	14	and	and	CCONJ
dti-1306	355	15	cdk4	cdk4	NOUN
dti-1306	355	16	genes	gene	NOUN
dti-1306	355	17	have	have	VERB
dti-1306	355	18	frequent	frequent	ADJ
dti-1306	355	19	mutations	mutation	NOUN
dti-1306	355	20	of	of	ADP
dti-1306	355	21	the	the	DET
dti-1306	355	22	retinoblastoma	retinoblastoma	NOUN
dti-1306	355	23	gene	gene	NOUN
dti-1306	355	24	.	.	PUNCT
dti-1306	356	1	oncogene	oncogene	NOUN
dti-1306	356	2	.	.	PUNCT
dti-1306	356	3	,	,	PUNCT
dti-1306	356	4	13:1065–72	13:1065–72	PROPN
dti-1306	356	5	.	.	PUNCT
dti-1306	357	1	ichimura	ichimura	PROPN
dti-1306	357	2	,	,	PUNCT
dti-1306	357	3	k.	k.	PROPN
dti-1306	357	4	et	et	PROPN
dti-1306	358	1	al	al	PROPN
dti-1306	358	2	.	.	PROPN
dti-1306	358	3	2000	2000	NUM
dti-1306	358	4	.	.	PUNCT
dti-1306	359	1	deregulation	deregulation	NOUN
dti-1306	359	2	of	of	ADP
dti-1306	359	3	the	the	DET
dti-1306	359	4	p14arf	p14arf	PROPN
dti-1306	359	5	/	/	SYM
dti-1306	359	6	mdm2	mdm2	PROPN
dti-1306	359	7	/	/	SYM
dti-1306	359	8	p53	p53	NOUN
dti-1306	359	9	pathway	pathway	NOUN
dti-1306	359	10	is	be	AUX
dti-1306	359	11	a	a	DET
dti-1306	359	12	prerequisite	prerequisite	NOUN
dti-1306	359	13	for	for	ADP
dti-1306	359	14	human	human	ADJ
dti-1306	359	15	astrocytic	astrocytic	ADJ
dti-1306	359	16	gliomas	glioma	NOUN
dti-1306	359	17	with	with	ADP
dti-1306	359	18	g1	g1	PROPN
dti-1306	359	19	-	-	PUNCT
dti-1306	359	20	s	s	NOUN
dti-1306	359	21	transition	transition	NOUN
dti-1306	359	22	control	control	NOUN
dti-1306	359	23	gene	gene	NOUN
dti-1306	359	24	abnormalities	abnormality	NOUN
dti-1306	359	25	.	.	PUNCT
dti-1306	360	1	cancer	cancer	NOUN
dti-1306	360	2	res	re	NOUN
dti-1306	360	3	.	.	PUNCT
dti-1306	360	4	,	,	PUNCT
dti-1306	360	5	60:417–24	60:417–24	PROPN
dti-1306	360	6	.	.	PUNCT
dti-1306	361	1	jannot	jannot	PROPN
dti-1306	361	2	,	,	PUNCT
dti-1306	361	3	g.	g.	PROPN
dti-1306	361	4	and	and	CCONJ
dti-1306	361	5	simard	simard	PROPN
dti-1306	361	6	,	,	PUNCT
dti-1306	361	7	m.j	m.j	PROPN
dti-1306	361	8	.	.	PROPN
dti-1306	361	9	2006	2006	NUM
dti-1306	361	10	.	.	PUNCT
dti-1306	362	1	tumour	tumour	NOUN
dti-1306	362	2	-	-	PUNCT
dti-1306	362	3	related	relate	VERB
dti-1306	362	4	micrornas	microrna	NOUN
dti-1306	362	5	functions	function	NOUN
dti-1306	362	6	in	in	ADP
dti-1306	362	7	caenorhabditis	caenorhabditis	ADJ
dti-1306	362	8	elegans	elegan	NOUN
dti-1306	362	9	.	.	PUNCT
dti-1306	363	1	oncogene	oncogene	NOUN
dti-1306	363	2	,	,	PUNCT
dti-1306	363	3	25:6197–201	25:6197–201	NUM
dti-1306	363	4	.	.	PUNCT
dti-1306	364	1	jovanovic	jovanovic	PROPN
dti-1306	364	2	,	,	PUNCT
dti-1306	364	3	m.	m.	NOUN
dti-1306	364	4	and	and	CCONJ
dti-1306	364	5	hengartner	hengartner	NOUN
dti-1306	364	6	,	,	PUNCT
dti-1306	364	7	m.o	m.o	PROPN
dti-1306	364	8	.	.	PROPN
dti-1306	364	9	2006	2006	NUM
dti-1306	364	10	.	.	PUNCT
dti-1306	365	1	mirnas	mirna	NOUN
dti-1306	365	2	and	and	CCONJ
dti-1306	365	3	apoptosis	apoptosis	NOUN
dti-1306	365	4	:	:	PUNCT
dti-1306	365	5	rnas	rna	NOUN
dti-1306	365	6	to	to	PART
dti-1306	365	7	die	die	VERB
dti-1306	365	8	for	for	ADP
dti-1306	365	9	.	.	PUNCT
dti-1306	366	1	oncogene	oncogene	NOUN
dti-1306	366	2	,	,	PUNCT
dti-1306	366	3	25:6176–87	25:6176–87	NUM
dti-1306	366	4	.	.	PUNCT
dti-1306	367	1	kanzawa	kanzawa	PROPN
dti-1306	367	2	,	,	PUNCT
dti-1306	367	3	t.	t.	PROPN
dti-1306	367	4	et	et	PROPN
dti-1306	367	5	al	al	PROPN
dti-1306	367	6	.	.	PROPN
dti-1306	367	7	2003	2003	NUM
dti-1306	367	8	.	.	PUNCT
dti-1306	368	1	inhibition	inhibition	NOUN
dti-1306	368	2	of	of	ADP
dti-1306	368	3	dna	dna	PROPN
dti-1306	368	4	repair	repair	NOUN
dti-1306	368	5	for	for	ADP
dti-1306	368	6	sensitizing	sensitize	VERB
dti-1306	368	7	resistant	resistant	ADJ
dti-1306	368	8	glioma	glioma	NOUN
dti-1306	368	9	cells	cell	NOUN
dti-1306	368	10	to	to	PART
dti-1306	368	11	temozolomide	temozolomide	VERB
dti-1306	368	12	.	.	PUNCT
dti-1306	369	1	j.	j.	PROPN
dti-1306	369	2	neurosurg	neurosurg	PROPN
dti-1306	369	3	.	.	PROPN
dti-1306	369	4	,	,	PUNCT
dti-1306	369	5	99:1047–52	99:1047–52	X
dti-1306	369	6	.	.	PUNCT
dti-1306	370	1	kent	kent	PROPN
dti-1306	370	2	,	,	PUNCT
dti-1306	370	3	o.a	o.a	PROPN
dti-1306	370	4	.	.	PROPN
dti-1306	370	5	and	and	CCONJ
dti-1306	370	6	mendell	mendell	PROPN
dti-1306	370	7	,	,	PUNCT
dti-1306	370	8	j.t	j.t	PROPN
dti-1306	370	9	.	.	PROPN
dti-1306	370	10	2006	2006	NUM
dti-1306	370	11	.	.	PUNCT
dti-1306	371	1	a	a	DET
dti-1306	371	2	small	small	ADJ
dti-1306	371	3	piece	piece	NOUN
dti-1306	371	4	in	in	ADP
dti-1306	371	5	the	the	DET
dti-1306	371	6	cancer	cancer	NOUN
dti-1306	371	7	puzzle	puzzle	NOUN
dti-1306	371	8	:	:	PUNCT
dti-1306	371	9	micrornas	microrna	NOUN
dti-1306	371	10	as	as	ADP
dti-1306	371	11	tumor	tumor	NOUN
dti-1306	371	12	suppressors	suppressor	NOUN
dti-1306	371	13	and	and	CCONJ
dti-1306	371	14	oncogenes	oncogene	NOUN
dti-1306	371	15	.	.	PUNCT
dti-1306	372	1	oncogene	oncogene	NOUN
dti-1306	372	2	,	,	PUNCT
dti-1306	372	3	25:6188–96	25:6188–96	NUM
dti-1306	372	4	.	.	PUNCT
dti-1306	373	1	kim	kim	PROPN
dti-1306	373	2	,	,	PUNCT
dti-1306	373	3	t.y	t.y	PROPN
dti-1306	373	4	.	.	PROPN
dti-1306	373	5	et	et	PROPN
dti-1306	373	6	al	al	PROPN
dti-1306	373	7	.	.	PROPN
dti-1306	373	8	2006	2006	NUM
dti-1306	373	9	.	.	PUNCT
dti-1306	374	1	epigenomic	epigenomic	ADJ
dti-1306	374	2	profi	profi	PROPN
dti-1306	374	3	ling	ling	PROPN
dti-1306	374	4	reveals	reveal	VERB
dti-1306	374	5	novel	novel	ADJ
dti-1306	374	6	and	and	CCONJ
dti-1306	374	7	frequent	frequent	ADJ
dti-1306	374	8	targets	target	NOUN
dti-1306	374	9	of	of	ADP
dti-1306	374	10	aberrant	aberrant	ADJ
dti-1306	374	11	dna	dna	PROPN
dti-1306	374	12	methylation	methylation	NOUN
dti-1306	374	13	-	-	PUNCT
dti-1306	374	14	mediated	mediate	VERB
dti-1306	374	15	silencing	silence	VERB
dti-1306	374	16	in	in	ADP
dti-1306	374	17	malignant	malignant	ADJ
dti-1306	374	18	glioma	glioma	NOUN
dti-1306	374	19	.	.	PUNCT
dti-1306	375	1	cancer	cancer	NOUN
dti-1306	375	2	res	re	NOUN
dti-1306	375	3	.	.	PROPN
dti-1306	375	4	,	,	PUNCT
dti-1306	375	5	66:7490–501	66:7490–501	PROPN
dti-1306	375	6	.	.	PUNCT
dti-1306	375	7	komine	komine	PROPN
dti-1306	375	8	,	,	PUNCT
dti-1306	375	9	c.	c.	PROPN
dti-1306	375	10	et	et	PROPN
dti-1306	375	11	al	al	PROPN
dti-1306	375	12	.	.	PROPN
dti-1306	375	13	2003	2003	NUM
dti-1306	375	14	.	.	PUNCT
dti-1306	376	1	promoter	promoter	NOUN
dti-1306	376	2	hypermethylation	hypermethylation	NOUN
dti-1306	376	3	of	of	ADP
dti-1306	376	4	the	the	DET
dti-1306	376	5	dna	dna	PROPN
dti-1306	376	6	repair	repair	NOUN
dti-1306	376	7	gene	gene	NOUN
dti-1306	376	8	o6	o6	NOUN
dti-1306	376	9	-	-	PUNCT
dti-1306	376	10	methylguanine	methylguanine	NOUN
dti-1306	376	11	-	-	PUNCT
dti-1306	376	12	dna	dna	NOUN
dti-1306	376	13	methyltransferase	methyltransferase	NOUN
dti-1306	376	14	is	be	AUX
dti-1306	376	15	an	an	DET
dti-1306	376	16	independent	independent	ADJ
dti-1306	376	17	predictor	predictor	NOUN
dti-1306	376	18	of	of	ADP
dti-1306	376	19	shortened	shorten	VERB
dti-1306	376	20	progression	progression	NOUN
dti-1306	376	21	free	free	ADJ
dti-1306	376	22	survival	survival	NOUN
dti-1306	376	23	in	in	ADP
dti-1306	376	24	patients	patient	NOUN
dti-1306	376	25	with	with	ADP
dti-1306	376	26	low	low	ADJ
dti-1306	376	27	grade	grade	NOUN
dti-1306	376	28	diffuse	diffuse	NOUN
dti-1306	376	29	astrocytomas	astrocytoma	NOUN
dti-1306	376	30	.	.	PUNCT
dti-1306	377	1	brain	brain	NOUN
dti-1306	377	2	pathol	pathol	NOUN
dti-1306	377	3	.	.	PUNCT
dti-1306	377	4	,	,	PUNCT
dti-1306	377	5	13:176–84	13:176–84	NOUN
dti-1306	377	6	.	.	PUNCT
dti-1306	378	1	kraft	kraft	PROPN
dti-1306	378	2	,	,	PUNCT
dti-1306	378	3	r.	r.	PROPN
dti-1306	378	4	et	et	PROPN
dti-1306	378	5	al	al	PROPN
dti-1306	378	6	.	.	PROPN
dti-1306	378	7	2003	2003	NUM
dti-1306	378	8	.	.	PUNCT
dti-1306	379	1	bk	bk	NOUN
dti-1306	379	2	channel	channel	NOUN
dti-1306	379	3	openers	opener	NOUN
dti-1306	379	4	inhibit	inhibit	VERB
dti-1306	379	5	migration	migration	NOUN
dti-1306	379	6	of	of	ADP
dti-1306	379	7	human	human	ADJ
dti-1306	379	8	glioma	glioma	NOUN
dti-1306	379	9	cells	cell	NOUN
dti-1306	379	10	.	.	PUNCT
dti-1306	380	1	pfl	pfl	ADJ
dti-1306	380	2	ugers	uger	NOUN
dti-1306	380	3	arch	arch	VERB
dti-1306	380	4	.	.	PUNCT
dti-1306	381	1	,	,	PUNCT
dti-1306	382	1	446:248–55	446:248–55	PROPN
dti-1306	382	2	.	.	PUNCT
dti-1306	383	1	leis	leis	PROPN
dti-1306	383	2	,	,	PUNCT
dti-1306	383	3	j.f	j.f	PROPN
dti-1306	383	4	.	.	PROPN
dti-1306	383	5	et	et	PROPN
dti-1306	383	6	al	al	PROPN
dti-1306	383	7	.	.	PROPN
dti-1306	383	8	2004	2004	NUM
dti-1306	383	9	.	.	PUNCT
dti-1306	384	1	central	central	ADJ
dti-1306	384	2	nervous	nervous	ADJ
dti-1306	384	3	system	system	NOUN
dti-1306	384	4	failure	failure	NOUN
dti-1306	384	5	in	in	ADP
dti-1306	384	6	patients	patient	NOUN
dti-1306	384	7	with	with	ADP
dti-1306	384	8	chronic	chronic	ADJ
dti-1306	384	9	myelogenous	myelogenous	ADJ
dti-1306	384	10	leukemia	leukemia	NOUN
dti-1306	384	11	lymphoid	lymphoid	NOUN
dti-1306	384	12	blast	blast	NOUN
dti-1306	384	13	crisis	crisis	NOUN
dti-1306	384	14	and	and	CCONJ
dti-1306	384	15	philadelphia	philadelphia	PROPN
dti-1306	384	16	chromosome	chromosome	VERB
dti-1306	384	17	positive	positive	ADJ
dti-1306	384	18	acute	acute	NOUN
dti-1306	384	19	lymphoblastic	lymphoblastic	ADJ
dti-1306	384	20	leukemia	leukemia	NOUN
dti-1306	384	21	treated	treat	VERB
dti-1306	384	22	with	with	ADP
dti-1306	384	23	imatinib	imatinib	NOUN
dti-1306	384	24	(	(	PUNCT
dti-1306	384	25	sti-571	sti-571	ADJ
dti-1306	384	26	)	)	PUNCT
dti-1306	384	27	.	.	PUNCT
dti-1306	385	1	leuk	leuk	PROPN
dti-1306	385	2	lymphoma	lymphoma	PROPN
dti-1306	385	3	.	.	PUNCT
dti-1306	385	4	,	,	PUNCT
dti-1306	385	5	45:695–8	45:695–8	NUM
dti-1306	385	6	.	.	PUNCT
dti-1306	386	1	levin	levin	PROPN
dti-1306	386	2	,	,	PUNCT
dti-1306	386	3	v.a	v.a	PROPN
dti-1306	386	4	.	.	PROPN
dti-1306	386	5	2007	2007	NUM
dti-1306	386	6	.	.	PUNCT
dti-1306	386	7	are	be	AUX
dti-1306	386	8	gliomas	glioma	NOUN
dti-1306	386	9	preventable	preventable	ADJ
dti-1306	386	10	?	?	PUNCT
dti-1306	387	1	recent	recent	ADJ
dti-1306	387	2	results	result	NOUN
dti-1306	387	3	cancer	cancer	NOUN
dti-1306	387	4	res	re	NOUN
dti-1306	387	5	.	.	PUNCT
dti-1306	387	6	,	,	PUNCT
dti-1306	388	1	174:205–5	174:205–5	NUM
dti-1306	388	2	.	.	PUNCT
dti-1306	389	1	libermann	libermann	PROPN
dti-1306	389	2	,	,	PUNCT
dti-1306	389	3	t.a	t.a	PROPN
dti-1306	389	4	.	.	PROPN
dti-1306	389	5	et	et	PROPN
dti-1306	389	6	al	al	PROPN
dti-1306	389	7	.	.	PROPN
dti-1306	389	8	1985	1985	NUM
dti-1306	389	9	.	.	PUNCT
dti-1306	390	1	amplifi	amplifi	PROPN
dti-1306	390	2	cation	cation	NOUN
dti-1306	390	3	,	,	PUNCT
dti-1306	390	4	enhanced	enhance	VERB
dti-1306	390	5	expression	expression	NOUN
dti-1306	390	6	and	and	CCONJ
dti-1306	390	7	possible	possible	ADJ
dti-1306	390	8	rearrangement	rearrangement	NOUN
dti-1306	390	9	of	of	ADP
dti-1306	390	10	egf	egf	PROPN
dti-1306	390	11	receptor	receptor	NOUN
dti-1306	390	12	gene	gene	NOUN
dti-1306	390	13	in	in	ADP
dti-1306	390	14	primary	primary	ADJ
dti-1306	390	15	human	human	ADJ
dti-1306	390	16	brain	brain	NOUN
dti-1306	390	17	tumours	tumour	NOUN
dti-1306	390	18	of	of	ADP
dti-1306	390	19	glial	glial	ADJ
dti-1306	390	20	origin	origin	NOUN
dti-1306	390	21	.	.	PUNCT
dti-1306	391	1	nature	nature	NOUN
dti-1306	391	2	,	,	PUNCT
dti-1306	391	3	313:144–7	313:144–7	NUM
dti-1306	391	4	.	.	PUNCT
dti-1306	392	1	lund	lund	PROPN
dti-1306	392	2	,	,	PUNCT
dti-1306	392	3	e.l	e.l	PROPN
dti-1306	392	4	.	.	PROPN
dti-1306	392	5	,	,	PUNCT
dti-1306	392	6	bastholm	bastholm	NOUN
dti-1306	392	7	,	,	PUNCT
dti-1306	392	8	l.	l.	PROPN
dti-1306	392	9	and	and	CCONJ
dti-1306	392	10	kristjansen	kristjansen	NOUN
dti-1306	392	11	,	,	PUNCT
dti-1306	392	12	p.e	p.e	PROPN
dti-1306	392	13	.	.	PROPN
dti-1306	392	14	2000	2000	NUM
dti-1306	392	15	.	.	PUNCT
dti-1306	393	1	therapeutic	therapeutic	ADJ
dti-1306	393	2	synergy	synergy	NOUN
dti-1306	393	3	of	of	ADP
dti-1306	393	4	tnp-470	tnp-470	NOUN
dti-1306	393	5	and	and	CCONJ
dti-1306	393	6	ionizing	ionize	VERB
dti-1306	393	7	radiation	radiation	NOUN
dti-1306	393	8	:	:	PUNCT
dti-1306	393	9	effects	effect	NOUN
dti-1306	393	10	on	on	ADP
dti-1306	393	11	tumor	tumor	NOUN
dti-1306	393	12	growth	growth	NOUN
dti-1306	393	13	,	,	PUNCT
dti-1306	393	14	vessel	vessel	NOUN
dti-1306	393	15	morphology	morphology	NOUN
dti-1306	393	16	,	,	PUNCT
dti-1306	393	17	and	and	CCONJ
dti-1306	393	18	angiogenesis	angiogenesis	NOUN
dti-1306	393	19	in	in	ADP
dti-1306	393	20	human	human	ADJ
dti-1306	393	21	glioblastoma	glioblastoma	NOUN
dti-1306	393	22	multiforme	multiforme	VERB
dti-1306	393	23	xenografts	xenograft	NOUN
dti-1306	393	24	.	.	PUNCT
dti-1306	394	1	clin	clin	PROPN
dti-1306	394	2	.	.	PUNCT
dti-1306	395	1	cancer	cancer	NOUN
dti-1306	395	2	res	re	NOUN
dti-1306	395	3	.	.	PROPN
dti-1306	395	4	,	,	PUNCT
dti-1306	396	1	6:971–8	6:971–8	X
dti-1306	396	2	.	.	PUNCT
dti-1306	396	3	lubbert	lubbert	PROPN
dti-1306	396	4	,	,	PUNCT
dti-1306	396	5	m.	m.	NOUN
dti-1306	396	6	2000	2000	NUM
dti-1306	396	7	.	.	PUNCT
dti-1306	397	1	dna	dna	PROPN
dti-1306	397	2	methylation	methylation	NOUN
dti-1306	397	3	inhibitors	inhibitor	NOUN
dti-1306	397	4	in	in	ADP
dti-1306	397	5	the	the	DET
dti-1306	397	6	treatment	treatment	NOUN
dti-1306	397	7	of	of	ADP
dti-1306	397	8	leukemias	leukemia	NOUN
dti-1306	397	9	,	,	PUNCT
dti-1306	397	10	myelodysplastic	myelodysplastic	ADJ
dti-1306	397	11	syndromes	syndrome	NOUN
dti-1306	397	12	and	and	CCONJ
dti-1306	397	13	hemoglobinopathies	hemoglobinopathy	NOUN
dti-1306	397	14	:	:	PUNCT
dti-1306	397	15	clinical	clinical	ADJ
dti-1306	397	16	results	result	NOUN
dti-1306	397	17	and	and	CCONJ
dti-1306	397	18	possible	possible	ADJ
dti-1306	397	19	mechanisms	mechanism	NOUN
dti-1306	397	20	of	of	ADP
dti-1306	397	21	action	action	NOUN
dti-1306	397	22	.	.	PUNCT
dti-1306	398	1	curr	curr	PROPN
dti-1306	398	2	.	.	PUNCT
dti-1306	399	1	top	top	PROPN
dti-1306	399	2	microbiol	microbiol	PROPN
dti-1306	399	3	.	.	PUNCT
dti-1306	400	1	immunol	immunol	NOUN
dti-1306	400	2	.	.	PROPN
dti-1306	400	3	,	,	PUNCT
dti-1306	400	4	249:135–64	249:135–64	PROPN
dti-1306	400	5	.	.	PUNCT
dti-1306	401	1	mashiyama	mashiyama	PROPN
dti-1306	401	2	,	,	PUNCT
dti-1306	401	3	s.	s.	PROPN
dti-1306	401	4	et	et	PROPN
dti-1306	401	5	al	al	PROPN
dti-1306	401	6	.	.	PROPN
dti-1306	401	7	1991	1991	NUM
dti-1306	401	8	.	.	PUNCT
dti-1306	402	1	detection	detection	NOUN
dti-1306	402	2	of	of	ADP
dti-1306	402	3	p53	p53	NOUN
dti-1306	402	4	gene	gene	NOUN
dti-1306	402	5	mutations	mutation	NOUN
dti-1306	402	6	in	in	ADP
dti-1306	402	7	human	human	ADJ
dti-1306	402	8	brain	brain	NOUN
dti-1306	402	9	tumors	tumor	NOUN
dti-1306	402	10	by	by	ADP
dti-1306	402	11	single	single	ADJ
dti-1306	402	12	-	-	PUNCT
dti-1306	402	13	strand	strand	NOUN
dti-1306	402	14	conformation	conformation	NOUN
dti-1306	402	15	polymorphism	polymorphism	NOUN
dti-1306	402	16	analysis	analysis	NOUN
dti-1306	402	17	of	of	ADP
dti-1306	402	18	polymerase	polymerase	NOUN
dti-1306	402	19	chain	chain	NOUN
dti-1306	402	20	reaction	reaction	NOUN
dti-1306	402	21	products	product	NOUN
dti-1306	402	22	.	.	PUNCT
dti-1306	403	1	oncogene	oncogene	NOUN
dti-1306	403	2	.	.	PUNCT
dti-1306	404	1	,	,	PUNCT
dti-1306	404	2	6:1313–8	6:1313–8	PROPN
dti-1306	404	3	.	.	PUNCT
dti-1306	405	1	mauceri	mauceri	PROPN
dti-1306	405	2	,	,	PUNCT
dti-1306	405	3	h.j	h.j	PROPN
dti-1306	405	4	.	.	PROPN
dti-1306	405	5	et	et	PROPN
dti-1306	405	6	al	al	PROPN
dti-1306	405	7	.	.	PROPN
dti-1306	405	8	1998	1998	NUM
dti-1306	405	9	.	.	PUNCT
dti-1306	406	1	combined	combine	VERB
dti-1306	406	2	effects	effect	NOUN
dti-1306	406	3	of	of	ADP
dti-1306	406	4	angiostatin	angiostatin	NOUN
dti-1306	406	5	and	and	CCONJ
dti-1306	406	6	ionizing	ionize	VERB
dti-1306	406	7	radiation	radiation	NOUN
dti-1306	406	8	in	in	ADP
dti-1306	406	9	antitumour	antitumour	NOUN
dti-1306	406	10	therapy	therapy	NOUN
dti-1306	406	11	.	.	PUNCT
dti-1306	407	1	nature	nature	NOUN
dti-1306	407	2	,	,	PUNCT
dti-1306	407	3	394:287–91	394:287–91	NUM
dti-1306	407	4	.	.	PUNCT
dti-1306	408	1	ma	ma	PROPN
dti-1306	408	2	,	,	PUNCT
dti-1306	408	3	h.i	h.i	PROPN
dti-1306	408	4	.	.	PROPN
dti-1306	408	5	et	et	PROPN
dti-1306	408	6	al	al	PROPN
dti-1306	408	7	.	.	PROPN
dti-1306	408	8	2002	2002	NUM
dti-1306	408	9	.	.	PUNCT
dti-1306	409	1	intratumoral	intratumoral	ADJ
dti-1306	409	2	gene	gene	NOUN
dti-1306	409	3	therapy	therapy	NOUN
dti-1306	409	4	of	of	ADP
dti-1306	409	5	malignant	malignant	ADJ
dti-1306	409	6	brain	brain	NOUN
dti-1306	409	7	tumor	tumor	NOUN
dti-1306	409	8	in	in	ADP
dti-1306	409	9	a	a	DET
dti-1306	409	10	rat	rat	NOUN
dti-1306	409	11	model	model	NOUN
dti-1306	409	12	with	with	ADP
dti-1306	409	13	angiostatin	angiostatin	NOUN
dti-1306	409	14	delivered	deliver	VERB
dti-1306	409	15	by	by	ADP
dti-1306	409	16	adeno	adeno	NOUN
dti-1306	409	17	-	-	PUNCT
dti-1306	409	18	associated	associate	VERB
dti-1306	409	19	viral	viral	ADJ
dti-1306	409	20	(	(	PUNCT
dti-1306	409	21	aav	aav	NOUN
dti-1306	409	22	)	)	PUNCT
dti-1306	409	23	vector	vector	NOUN
dti-1306	409	24	.	.	PUNCT
dti-1306	410	1	gene	gene	NOUN
dti-1306	410	2	ther	ther	ADV
dti-1306	410	3	.	.	PUNCT
dti-1306	410	4	,	,	PUNCT
dti-1306	411	1	9:2–11	9:2–11	NUM
dti-1306	411	2	.	.	PUNCT
dti-1306	412	1	mellinghoff	mellinghoff	PROPN
dti-1306	412	2	,	,	PUNCT
dti-1306	412	3	i.k	i.k	PROPN
dti-1306	412	4	.	.	PROPN
dti-1306	412	5	et	et	PROPN
dti-1306	412	6	al	al	PROPN
dti-1306	412	7	.	.	PROPN
dti-1306	412	8	2005	2005	NUM
dti-1306	412	9	.	.	PUNCT
dti-1306	413	1	molecular	molecular	ADJ
dti-1306	413	2	determinants	determinant	NOUN
dti-1306	413	3	of	of	ADP
dti-1306	413	4	the	the	DET
dti-1306	413	5	response	response	NOUN
dti-1306	413	6	of	of	ADP
dti-1306	413	7	glioblastomas	glioblastoma	NOUN
dti-1306	413	8	to	to	PART
dti-1306	413	9	egfr	egfr	VERB
dti-1306	413	10	kinase	kinase	PROPN
dti-1306	413	11	inhibitors	inhibitor	NOUN
dti-1306	413	12	.	.	PUNCT
dti-1306	414	1	n.	n.	PROPN
dti-1306	414	2	engl	engl	PROPN
dti-1306	414	3	.	.	PUNCT
dti-1306	415	1	j.	j.	PROPN
dti-1306	415	2	med	med	PROPN
dti-1306	415	3	.	.	PROPN
dti-1306	415	4	,	,	PUNCT
dti-1306	416	1	353:2012–24	353:2012–24	PROPN
dti-1306	416	2	.	.	PUNCT
dti-1306	416	3	nakamura	nakamura	PROPN
dti-1306	416	4	,	,	PUNCT
dti-1306	416	5	m.	m.	NOUN
dti-1306	416	6	et	et	PROPN
dti-1306	416	7	al	al	PROPN
dti-1306	416	8	.	.	PROPN
dti-1306	416	9	1996	1996	NUM
dti-1306	416	10	.	.	PUNCT
dti-1306	417	1	promoter	promoter	NOUN
dti-1306	417	2	hypermethylation	hypermethylation	NOUN
dti-1306	417	3	of	of	ADP
dti-1306	417	4	the	the	DET
dti-1306	417	5	rb1	rb1	PROPN
dti-1306	417	6	gene	gene	NOUN
dti-1306	417	7	in	in	ADP
dti-1306	417	8	glioblastomas	glioblastoma	NOUN
dti-1306	417	9	.	.	PUNCT
dti-1306	418	1	lab	lab	PROPN
dti-1306	418	2	invest	invest	PROPN
dti-1306	418	3	.	.	PUNCT
dti-1306	418	4	,	,	PUNCT
dti-1306	418	5	81:77–82	81:77–82	NUM
dti-1306	418	6	.	.	PUNCT
dti-1306	419	1	newton	newton	PROPN
dti-1306	419	2	,	,	PUNCT
dti-1306	419	3	h.b	h.b	PROPN
dti-1306	419	4	.	.	PROPN
dti-1306	419	5	2003	2003	NUM
dti-1306	419	6	.	.	PUNCT
dti-1306	420	1	molecular	molecular	ADJ
dti-1306	420	2	neuro	neuro	NOUN
dti-1306	420	3	-	-	PUNCT
dti-1306	420	4	oncology	oncology	NOUN
dti-1306	420	5	and	and	CCONJ
dti-1306	420	6	development	development	NOUN
dti-1306	420	7	of	of	ADP
dti-1306	420	8	targeted	target	VERB
dti-1306	420	9	therapeutic	therapeutic	ADJ
dti-1306	420	10	strategies	strategy	NOUN
dti-1306	420	11	for	for	ADP
dti-1306	420	12	brain	brain	NOUN
dti-1306	420	13	tumors	tumor	NOUN
dti-1306	420	14	.	.	PUNCT
dti-1306	421	1	part	part	NOUN
dti-1306	421	2	1	1	NUM
dti-1306	421	3	:	:	PUNCT
dti-1306	421	4	growth	growth	NOUN
dti-1306	421	5	factor	factor	NOUN
dti-1306	421	6	and	and	CCONJ
dti-1306	421	7	ras	ras	X
dti-1306	421	8	signaling	signal	VERB
dti-1306	421	9	pathways	pathway	NOUN
dti-1306	421	10	.	.	PUNCT
dti-1306	422	1	expert	expert	NOUN
dti-1306	422	2	rev	rev	PROPN
dti-1306	422	3	.	.	PROPN
dti-1306	422	4	anticancer	anticancer	NOUN
dti-1306	422	5	ther	ther	PROPN
dti-1306	422	6	.	.	PUNCT
dti-1306	422	7	,	,	PUNCT
dti-1306	422	8	3:595–614	3:595–614	NUM
dti-1306	422	9	.	.	PUNCT
dti-1306	423	1	ningaraj	ningaraj	PROPN
dti-1306	423	2	,	,	PUNCT
dti-1306	423	3	n.s	n.s	PROPN
dti-1306	423	4	.	.	PROPN
dti-1306	423	5	et	et	PROPN
dti-1306	423	6	al	al	PROPN
dti-1306	423	7	.	.	PROPN
dti-1306	423	8	2002	2002	NUM
dti-1306	423	9	.	.	PUNCT
dti-1306	424	1	regulation	regulation	NOUN
dti-1306	424	2	of	of	ADP
dti-1306	424	3	blood	blood	NOUN
dti-1306	424	4	-	-	PUNCT
dti-1306	424	5	brain	brain	NOUN
dti-1306	424	6	tumor	tumor	NOUN
dti-1306	424	7	barrier	barrier	NOUN
dti-1306	424	8	permeability	permeability	NOUN
dti-1306	424	9	by	by	ADP
dti-1306	424	10	calcium	calcium	NOUN
dti-1306	424	11	-	-	PUNCT
dti-1306	424	12	activated	activate	VERB
dti-1306	424	13	potassium	potassium	NOUN
dti-1306	424	14	channels	channel	NOUN
dti-1306	424	15	.	.	PUNCT
dti-1306	425	1	j.	j.	PROPN
dti-1306	425	2	pharmacol	pharmacol	PROPN
dti-1306	425	3	.	.	PUNCT
dti-1306	426	1	exp	exp	PROPN
dti-1306	426	2	.	.	PUNCT
dti-1306	427	1	ther	ther	PROPN
dti-1306	427	2	.	.	PUNCT
dti-1306	427	3	,	,	PUNCT
dti-1306	427	4	301:838–51	301:838–51	NUM
dti-1306	427	5	.	.	PUNCT
dti-1306	428	1	ningaraj	ningaraj	PROPN
dti-1306	428	2	,	,	PUNCT
dti-1306	428	3	n.s	n.s	PROPN
dti-1306	428	4	.	.	PROPN
dti-1306	428	5	,	,	PUNCT
dti-1306	428	6	rao	rao	PROPN
dti-1306	428	7	,	,	PUNCT
dti-1306	428	8	m.k	m.k	PROPN
dti-1306	428	9	.	.	PROPN
dti-1306	428	10	and	and	CCONJ
dti-1306	428	11	black	black	ADJ
dti-1306	428	12	,	,	PUNCT
dti-1306	428	13	k.l	k.l	PROPN
dti-1306	428	14	.	.	NOUN
dti-1306	428	15	2003a	2003a	NOUN
dti-1306	428	16	.	.	PUNCT
dti-1306	429	1	adenosine	adenosine	VERB
dti-1306	429	2	5′-triphosphate	5′-triphosphate	ADJ
dti-1306	429	3	-	-	PUNCT
dti-1306	429	4	sensitive	sensitive	ADJ
dti-1306	429	5	potassium	potassium	NOUN
dti-1306	429	6	channel	channel	NOUN
dti-1306	429	7	-	-	PUNCT
dti-1306	429	8	mediated	mediate	VERB
dti-1306	429	9	blood	blood	NOUN
dti-1306	429	10	-	-	PUNCT
dti-1306	429	11	brain	brain	NOUN
dti-1306	429	12	tumor	tumor	NOUN
dti-1306	429	13	barrier	barrier	NOUN
dti-1306	429	14	permeability	permeability	NOUN
dti-1306	429	15	increase	increase	NOUN
dti-1306	429	16	in	in	ADP
dti-1306	429	17	a	a	DET
dti-1306	429	18	rat	rat	NOUN
dti-1306	429	19	brain	brain	NOUN
dti-1306	429	20	tumor	tumor	NOUN
dti-1306	429	21	model	model	NOUN
dti-1306	429	22	.	.	PUNCT
dti-1306	430	1	cancer	cancer	NOUN
dti-1306	430	2	res	re	NOUN
dti-1306	430	3	.	.	PROPN
dti-1306	430	4	,	,	PUNCT
dti-1306	431	1	63:8899–911	63:8899–911	PROPN
dti-1306	431	2	.	.	PUNCT
dti-1306	432	1	ningaraj	ningaraj	PROPN
dti-1306	432	2	,	,	PUNCT
dti-1306	432	3	n.s	n.s	PROPN
dti-1306	432	4	.	.	PROPN
dti-1306	432	5	2006	2006	NUM
dti-1306	432	6	.	.	PUNCT
dti-1306	433	1	drug	drug	NOUN
dti-1306	433	2	delivery	delivery	NOUN
dti-1306	433	3	to	to	PART
dti-1306	433	4	brain	brain	NOUN
dti-1306	433	5	tumours	tumour	NOUN
dti-1306	433	6	:	:	PUNCT
dti-1306	433	7	challenges	challenge	NOUN
dti-1306	433	8	and	and	CCONJ
dti-1306	433	9	progress	progress	NOUN
dti-1306	433	10	.	.	PUNCT
dti-1306	434	1	expert	expert	NOUN
dti-1306	434	2	opin	opin	NOUN
dti-1306	434	3	.	.	PUNCT
dti-1306	435	1	drug	drug	NOUN
dti-1306	435	2	deliv	deliv	NOUN
dti-1306	435	3	.	.	PUNCT
dti-1306	435	4	,	,	PUNCT
dti-1306	435	5	3:499–509	3:499–509	NOUN
dti-1306	435	6	.	.	PUNCT
dti-1306	436	1	o’driscoll	o’driscoll	NOUN
dti-1306	436	2	l.	l.	PROPN
dti-1306	436	3	2006	2006	NUM
dti-1306	436	4	.	.	PUNCT
dti-1306	437	1	the	the	DET
dti-1306	437	2	emerging	emerge	VERB
dti-1306	437	3	world	world	NOUN
dti-1306	437	4	of	of	ADP
dti-1306	437	5	micrornas	microrna	NOUN
dti-1306	437	6	.	.	PUNCT
dti-1306	438	1	anticancer	anticancer	NOUN
dti-1306	438	2	res	re	NOUN
dti-1306	438	3	.	.	PROPN
dti-1306	438	4	,	,	PUNCT
dti-1306	438	5	26:4271–8	26:4271–8	X
dti-1306	438	6	.	.	PUNCT
dti-1306	439	1	olsen	olsen	PROPN
dti-1306	439	2	,	,	PUNCT
dti-1306	439	3	m.l	m.l	PROPN
dti-1306	439	4	.	.	PROPN
dti-1306	439	5	,	,	PUNCT
dti-1306	439	6	weaver	weaver	PROPN
dti-1306	439	7	,	,	PUNCT
dti-1306	439	8	a.k	a.k	PROPN
dti-1306	439	9	.	.	PROPN
dti-1306	439	10	,	,	PUNCT
dti-1306	439	11	ritch	ritch	PROPN
dti-1306	439	12	,	,	PUNCT
dti-1306	439	13	p.s	p.s	PROPN
dti-1306	439	14	.	.	PROPN
dti-1306	439	15	,	,	PUNCT
dti-1306	439	16	sontheimer	sontheimer	PROPN
dti-1306	439	17	,	,	PUNCT
dti-1306	439	18	h.	h.	PROPN
dti-1306	439	19	2004	2004	NUM
dti-1306	439	20	.	.	PUNCT
dti-1306	440	1	modulation	modulation	NOUN
dti-1306	440	2	of	of	ADP
dti-1306	440	3	glioma	glioma	NOUN
dti-1306	440	4	bk	bk	ADP
dti-1306	440	5	channels	channel	NOUN
dti-1306	440	6	via	via	ADP
dti-1306	440	7	erbb2	erbb2	PROPN
dti-1306	440	8	,	,	PUNCT
dti-1306	440	9	81:2179–89	81:2179–89	NUM
dti-1306	440	10	.	.	PUNCT
dti-1306	441	1	osada	osada	PROPN
dti-1306	441	2	,	,	PUNCT
dti-1306	441	3	h.	h.	PROPN
dti-1306	441	4	and	and	CCONJ
dti-1306	441	5	takahashi	takahashi	PROPN
dti-1306	441	6	,	,	PUNCT
dti-1306	441	7	t.	t.	PROPN
dti-1306	441	8	2006	2006	NUM
dti-1306	441	9	.	.	PUNCT
dti-1306	442	1	micrornas	microrna	NOUN
dti-1306	442	2	in	in	ADP
dti-1306	442	3	biological	biological	ADJ
dti-1306	442	4	processes	process	NOUN
dti-1306	442	5	and	and	CCONJ
dti-1306	442	6	carcinogenesis	carcinogenesis	NOUN
dti-1306	442	7	.	.	PUNCT
dti-1306	443	1	carcinogenesis	carcinogenesis	NOUN
dti-1306	443	2	,	,	PUNCT
dti-1306	443	3	28:2–12	28:2–12	NUM
dti-1306	443	4	.	.	PUNCT
dti-1306	444	1	pardridge	pardridge	NOUN
dti-1306	444	2	,	,	PUNCT
dti-1306	444	3	w.m	w.m	PROPN
dti-1306	444	4	.	.	PROPN
dti-1306	444	5	et	et	PROPN
dti-1306	444	6	al	al	PROPN
dti-1306	444	7	.	.	PROPN
dti-1306	444	8	1992	1992	NUM
dti-1306	444	9	.	.	PUNCT
dti-1306	445	1	blood	blood	NOUN
dti-1306	445	2	-	-	PUNCT
dti-1306	445	3	brain	brain	NOUN
dti-1306	445	4	barrier	barrier	NOUN
dti-1306	445	5	and	and	CCONJ
dti-1306	445	6	new	new	ADJ
dti-1306	445	7	approaches	approach	NOUN
dti-1306	445	8	to	to	ADP
dti-1306	445	9	brain	brain	NOUN
dti-1306	445	10	drug	drug	NOUN
dti-1306	445	11	delivery	delivery	NOUN
dti-1306	445	12	.	.	PUNCT
dti-1306	446	1	west	west	PROPN
dti-1306	446	2	j.	j.	PROPN
dti-1306	446	3	med	med	PROPN
dti-1306	446	4	.	.	PROPN
dti-1306	446	5	,	,	PUNCT
dti-1306	446	6	156:281–6	156:281–6	NUM
dti-1306	446	7	.	.	PUNCT
dti-1306	447	1	pardridge	pardridge	PROPN
dti-1306	447	2	,	,	PUNCT
dti-1306	447	3	w.m	w.m	PROPN
dti-1306	447	4	.	.	PROPN
dti-1306	447	5	2001	2001	NUM
dti-1306	447	6	.	.	PUNCT
dti-1306	448	1	drug	drug	NOUN
dti-1306	448	2	targeting	targeting	NOUN
dti-1306	448	3	,	,	PUNCT
dti-1306	448	4	drug	drug	NOUN
dti-1306	448	5	discovery	discovery	NOUN
dti-1306	448	6	,	,	PUNCT
dti-1306	448	7	and	and	CCONJ
dti-1306	448	8	brain	brain	NOUN
dti-1306	448	9	drug	drug	NOUN
dti-1306	448	10	development	development	NOUN
dti-1306	448	11	.	.	PUNCT
dti-1306	449	1	in	in	ADP
dti-1306	449	2	:	:	PUNCT
dti-1306	449	3	brain	brain	NOUN
dti-1306	449	4	drug	drug	NOUN
dti-1306	449	5	targeting	target	VERB
dti-1306	449	6	:	:	PUNCT
dti-1306	449	7	the	the	DET
dti-1306	449	8	future	future	NOUN
dti-1306	449	9	of	of	ADP
dti-1306	449	10	brain	brain	NOUN
dti-1306	449	11	drug	drug	NOUN
dti-1306	449	12	development	development	NOUN
dti-1306	449	13	.	.	PUNCT
dti-1306	450	1	cambridge	cambridge	PROPN
dti-1306	450	2	:	:	PUNCT
dti-1306	450	3	cambridge	cambridge	PROPN
dti-1306	450	4	university	university	PROPN
dti-1306	450	5	press	press	NOUN
dti-1306	450	6	,	,	PUNCT
dti-1306	450	7	pp	pp	ADP
dti-1306	450	8	.	.	PUNCT
dti-1306	451	1	1–13	1–13	NOUN
dti-1306	451	2	.	.	PUNCT
dti-1306	452	1	plumb	plumb	PROPN
dti-1306	452	2	,	,	PUNCT
dti-1306	452	3	j.a	j.a	PROPN
dti-1306	452	4	.	.	PROPN
dti-1306	452	5	et	et	PROPN
dti-1306	452	6	al	al	PROPN
dti-1306	452	7	.	.	PROPN
dti-1306	452	8	2000	2000	NUM
dti-1306	452	9	.	.	PUNCT
dti-1306	453	1	reversal	reversal	NOUN
dti-1306	453	2	of	of	ADP
dti-1306	453	3	drug	drug	NOUN
dti-1306	453	4	resistance	resistance	NOUN
dti-1306	453	5	in	in	ADP
dti-1306	453	6	human	human	ADJ
dti-1306	453	7	tumor	tumor	NOUN
dti-1306	453	8	xenografts	xenograft	NOUN
dti-1306	453	9	by	by	ADP
dti-1306	453	10	2′-deoxy-5	2′-deoxy-5	NUM
dti-1306	453	11	-	-	PUNCT
dti-1306	453	12	azacytidine	azacytidine	NOUN
dti-1306	453	13	-	-	PUNCT
dti-1306	453	14	induced	induce	VERB
dti-1306	453	15	demethylation	demethylation	NOUN
dti-1306	453	16	of	of	ADP
dti-1306	453	17	the	the	DET
dti-1306	453	18	hmlh1	hmlh1	PROPN
dti-1306	453	19	gene	gene	NOUN
dti-1306	453	20	promoter	promoter	NOUN
dti-1306	453	21	.	.	PUNCT
dti-1306	454	1	cancer	cancer	NOUN
dti-1306	454	2	res	re	NOUN
dti-1306	454	3	.	.	PUNCT
dti-1306	454	4	,	,	PUNCT
dti-1306	454	5	60:6039–44	60:6039–44	X
dti-1306	454	6	.	.	PUNCT
dti-1306	455	1	pollack	pollack	PROPN
dti-1306	455	2	,	,	PUNCT
dti-1306	455	3	i.f	i.f	PROPN
dti-1306	455	4	.	.	PROPN
dti-1306	455	5	et	et	PROPN
dti-1306	455	6	al	al	PROPN
dti-1306	455	7	.	.	PROPN
dti-1306	455	8	2007	2007	NUM
dti-1306	455	9	.	.	PUNCT
dti-1306	456	1	phase	phase	NOUN
dti-1306	456	2	i	i	PRON
dti-1306	456	3	trial	trial	NOUN
dti-1306	456	4	of	of	ADP
dti-1306	456	5	imatinib	imatinib	NOUN
dti-1306	456	6	in	in	ADP
dti-1306	456	7	children	child	NOUN
dti-1306	456	8	with	with	ADP
dti-1306	456	9	newly	newly	ADV
dti-1306	456	10	diagnosed	diagnose	VERB
dti-1306	456	11	brainstem	brainstem	NOUN
dti-1306	456	12	and	and	CCONJ
dti-1306	456	13	recurrent	recurrent	ADJ
dti-1306	456	14	malignant	malignant	ADJ
dti-1306	456	15	gliomas	glioma	NOUN
dti-1306	456	16	:	:	PUNCT
dti-1306	456	17	a	a	DET
dti-1306	456	18	pediatric	pediatric	ADJ
dti-1306	456	19	brain	brain	NOUN
dti-1306	456	20	tumor	tumor	PROPN
dti-1306	456	21	consortium	consortium	PROPN
dti-1306	456	22	report	report	NOUN
dti-1306	456	23	.	.	PUNCT
dti-1306	457	1	neuro	neuro	NOUN
dti-1306	457	2	-	-	PUNCT
dti-1306	457	3	oncol	oncol	PROPN
dti-1306	457	4	.	.	PUNCT
dti-1306	457	5	,	,	PUNCT
dti-1306	458	1	9:145–60	9:145–60	PROPN
dti-1306	458	2	.	.	PUNCT
dti-1306	458	3	rao	rao	PROPN
dti-1306	458	4	,	,	PUNCT
dti-1306	458	5	m.	m.	NOUN
dti-1306	458	6	and	and	CCONJ
dti-1306	458	7	ningaraj	ningaraj	ADJ
dti-1306	458	8	,	,	PUNCT
dti-1306	458	9	n.	n.	PROPN
dti-1306	458	10	2001	2001	NUM
dti-1306	458	11	.	.	PUNCT
dti-1306	459	1	activation	activation	NOUN
dti-1306	459	2	of	of	ADP
dti-1306	459	3	calcium	calcium	NOUN
dti-1306	459	4	-	-	PUNCT
dti-1306	459	5	dependent	dependent	ADJ
dti-1306	459	6	potassium	potassium	NOUN
dti-1306	459	7	channels	channel	NOUN
dti-1306	459	8	elicits	elicit	VERB
dti-1306	459	9	selective	selective	ADJ
dti-1306	459	10	glioma	glioma	NOUN
dti-1306	459	11	cell	cell	NOUN
dti-1306	459	12	death	death	NOUN
dti-1306	459	13	.	.	PUNCT
dti-1306	460	1	in	in	ADP
dti-1306	460	2	:	:	PUNCT
dti-1306	460	3	aacr	aacr	ADJ
dti-1306	460	4	-	-	PUNCT
dti-1306	460	5	ncieortc	ncieortc	PROPN
dti-1306	460	6	.	.	PUNCT
dti-1306	461	1	rege	rege	PROPN
dti-1306	461	2	,	,	PUNCT
dti-1306	461	3	t.a	t.a	PROPN
dti-1306	461	4	.	.	PROPN
dti-1306	461	5	,	,	PUNCT
dti-1306	461	6	fears	fear	NOUN
dti-1306	461	7	,	,	PUNCT
dti-1306	461	8	c.y	c.y	PROPN
dti-1306	461	9	.	.	PROPN
dti-1306	461	10	and	and	CCONJ
dti-1306	461	11	gladson	gladson	PROPN
dti-1306	461	12	,	,	PUNCT
dti-1306	461	13	c.l	c.l	PROPN
dti-1306	461	14	.	.	PROPN
dti-1306	461	15	2005	2005	NUM
dti-1306	461	16	.	.	PUNCT
dti-1306	462	1	endogenous	endogenous	ADJ
dti-1306	462	2	inhibitors	inhibitor	NOUN
dti-1306	462	3	of	of	ADP
dti-1306	462	4	angiogenesis	angiogenesis	NOUN
dti-1306	462	5	in	in	ADP
dti-1306	462	6	malignant	malignant	ADJ
dti-1306	462	7	gliomas	glioma	NOUN
dti-1306	462	8	:	:	PUNCT
dti-1306	462	9	nature	nature	NOUN
dti-1306	462	10	’s	’s	PART
dti-1306	462	11	antiangiogenic	antiangiogenic	ADJ
dti-1306	462	12	therapy	therapy	NOUN
dti-1306	462	13	.	.	PUNCT
dti-1306	463	1	neuro	neuro	NOUN
dti-1306	463	2	-	-	PUNCT
dti-1306	463	3	oncol	oncol	PROPN
dti-1306	463	4	.	.	PUNCT
dti-1306	464	1	,	,	PUNCT
dti-1306	464	2	7:106–21	7:106–21	X
dti-1306	464	3	.	.	PUNCT
dti-1306	465	1	reijneveld	reijneveld	PROPN
dti-1306	465	2	,	,	PUNCT
dti-1306	465	3	j.c	j.c	PROPN
dti-1306	465	4	.	.	PROPN
dti-1306	465	5	,	,	PUNCT
dti-1306	465	6	voest	vo	ADJ
dti-1306	465	7	,	,	PUNCT
dti-1306	465	8	e.e	e.e	PROPN
dti-1306	465	9	.	.	PROPN
dti-1306	465	10	and	and	CCONJ
dti-1306	465	11	taphoorn	taphoorn	VERB
dti-1306	465	12	,	,	PUNCT
dti-1306	465	13	m.j	m.j	PROPN
dti-1306	465	14	.	.	PROPN
dti-1306	465	15	2000	2000	NUM
dti-1306	465	16	.	.	PUNCT
dti-1306	466	1	angiogenesis	angiogenesis	NOUN
dti-1306	466	2	in	in	ADP
dti-1306	466	3	malignant	malignant	ADJ
dti-1306	466	4	primary	primary	ADJ
dti-1306	466	5	and	and	CCONJ
dti-1306	466	6	metastatic	metastatic	ADJ
dti-1306	466	7	brain	brain	NOUN
dti-1306	466	8	tumors	tumor	NOUN
dti-1306	466	9	.	.	PUNCT
dti-1306	467	1	j.	j.	PROPN
dti-1306	467	2	neurol	neurol	PROPN
dti-1306	467	3	.	.	PUNCT
dti-1306	467	4	,	,	PUNCT
dti-1306	467	5	247:597–608	247:597–608	NUM
dti-1306	467	6	.	.	PUNCT
dti-1306	468	1	reardon	reardon	PROPN
dti-1306	468	2	,	,	PUNCT
dti-1306	468	3	d.a	d.a	PROPN
dti-1306	468	4	.	.	PROPN
dti-1306	468	5	et	et	PROPN
dti-1306	468	6	al	al	PROPN
dti-1306	468	7	.	.	PROPN
dti-1306	468	8	2005	2005	NUM
dti-1306	468	9	.	.	PUNCT
dti-1306	469	1	phase	phase	NOUN
dti-1306	469	2	ii	ii	PROPN
dti-1306	469	3	study	study	NOUN
dti-1306	469	4	of	of	ADP
dti-1306	469	5	imatinib	imatinib	NOUN
dti-1306	469	6	mesylate	mesylate	NOUN
dti-1306	469	7	plus	plus	CCONJ
dti-1306	469	8	hydroxyurea	hydroxyurea	NOUN
dti-1306	469	9	in	in	ADP
dti-1306	469	10	adults	adult	NOUN
dti-1306	469	11	with	with	ADP
dti-1306	469	12	recurrent	recurrent	ADJ
dti-1306	469	13	glioblastoma	glioblastoma	NOUN
dti-1306	469	14	multiforme	multiforme	NOUN
dti-1306	469	15	.	.	PUNCT
dti-1306	470	1	j.	j.	PROPN
dti-1306	470	2	clin	clin	PROPN
dti-1306	470	3	.	.	PUNCT
dti-1306	471	1	oncol	oncol	PROPN
dti-1306	471	2	.	.	PUNCT
dti-1306	471	3	,	,	PUNCT
dti-1306	471	4	23:9359–68	23:9359–68	X
dti-1306	471	5	.	.	PUNCT
dti-1306	472	1	rich	rich	ADJ
dti-1306	472	2	,	,	PUNCT
dti-1306	472	3	j.n	j.n	PROPN
dti-1306	472	4	.	.	PROPN
dti-1306	472	5	and	and	CCONJ
dti-1306	472	6	bigner	bigner	NOUN
dti-1306	472	7	,	,	PUNCT
dti-1306	472	8	d.d	d.d	PROPN
dti-1306	472	9	.	.	PROPN
dti-1306	472	10	2004	2004	NUM
dti-1306	472	11	.	.	PUNCT
dti-1306	473	1	development	development	NOUN
dti-1306	473	2	of	of	ADP
dti-1306	473	3	novel	novel	ADJ
dti-1306	473	4	targeted	target	VERB
dti-1306	473	5	therapies	therapy	NOUN
dti-1306	473	6	in	in	ADP
dti-1306	473	7	the	the	DET
dti-1306	473	8	treatment	treatment	NOUN
dti-1306	473	9	of	of	ADP
dti-1306	473	10	malignant	malignant	ADJ
dti-1306	473	11	glioma	glioma	NOUN
dti-1306	473	12	.	.	PUNCT
dti-1306	474	1	nat	nat	PROPN
dti-1306	474	2	.	.	PUNCT
dti-1306	475	1	rev	rev	PROPN
dti-1306	475	2	.	.	PROPN
dti-1306	475	3	drug	drug	NOUN
dti-1306	475	4	discov	discov	PROPN
dti-1306	475	5	.	.	PUNCT
dti-1306	475	6	,	,	PUNCT
dti-1306	475	7	3:430–46	3:430–46	PROPN
dti-1306	475	8	.	.	PROPN
dti-1306	475	9	207	207	NUM
dti-1306	475	10	targeted	target	VERB
dti-1306	475	11	brain	brain	NOUN
dti-1306	475	12	tumor	tumor	NOUN
dti-1306	475	13	treatment	treatment	NOUN
dti-1306	475	14	drug	drug	NOUN
dti-1306	475	15	target	target	NOUN
dti-1306	475	16	insights	insight	NOUN
dti-1306	475	17	2007	2007	NUM
dti-1306	475	18	:	:	PUNCT
dti-1306	475	19	2	2	NUM
dti-1306	475	20	robinson	robinson	PROPN
dti-1306	475	21	,	,	PUNCT
dti-1306	475	22	s.p	s.p	PROPN
dti-1306	475	23	.	.	PROPN
dti-1306	475	24	et	et	PROPN
dti-1306	475	25	al	al	PROPN
dti-1306	475	26	.	.	PROPN
dti-1306	475	27	2003	2003	NUM
dti-1306	475	28	.	.	PUNCT
dti-1306	476	1	tumour	tumour	NOUN
dti-1306	476	2	dose	dose	NOUN
dti-1306	476	3	response	response	NOUN
dti-1306	476	4	to	to	ADP
dti-1306	476	5	the	the	DET
dti-1306	476	6	antivascular	antivascular	ADJ
dti-1306	476	7	agent	agent	NOUN
dti-1306	476	8	zd6126	zd6126	NOUN
dti-1306	476	9	assessed	assess	VERB
dti-1306	476	10	by	by	ADP
dti-1306	476	11	magnetic	magnetic	ADJ
dti-1306	476	12	resonance	resonance	NOUN
dti-1306	476	13	imaging	imaging	NOUN
dti-1306	476	14	.	.	PUNCT
dti-1306	477	1	br	br	PROPN
dti-1306	477	2	.	.	PUNCT
dti-1306	478	1	j.	j.	PROPN
dti-1306	478	2	cancer	cancer	PROPN
dti-1306	478	3	.	.	PUNCT
dti-1306	478	4	,	,	PUNCT
dti-1306	478	5	88:1592–7	88:1592–7	NUM
dti-1306	478	6	.	.	PUNCT
dti-1306	479	1	saito	saito	PROPN
dti-1306	479	2	,	,	PUNCT
dti-1306	479	3	y.	y.	PROPN
dti-1306	479	4	and	and	CCONJ
dti-1306	479	5	jones	jones	PROPN
dti-1306	479	6	,	,	PUNCT
dti-1306	479	7	p.a	p.a	PROPN
dti-1306	479	8	.	.	PROPN
dti-1306	479	9	2006	2006	NUM
dti-1306	479	10	.	.	PUNCT
dti-1306	480	1	epigenetic	epigenetic	ADJ
dti-1306	480	2	activation	activation	NOUN
dti-1306	480	3	of	of	ADP
dti-1306	480	4	tumor	tumor	NOUN
dti-1306	480	5	suppressor	suppressor	NOUN
dti-1306	480	6	micrornas	microrna	NOUN
dti-1306	480	7	in	in	ADP
dti-1306	480	8	human	human	ADJ
dti-1306	480	9	cancer	cancer	NOUN
dti-1306	480	10	cells	cell	NOUN
dti-1306	480	11	.	.	PUNCT
dti-1306	481	1	cell	cell	NOUN
dti-1306	481	2	cycle	cycle	NOUN
dti-1306	481	3	,	,	PUNCT
dti-1306	481	4	5:2220–22	5:2220–22	NUM
dti-1306	481	5	.	.	PUNCT
dti-1306	481	6	shusterman	shusterman	PROPN
dti-1306	481	7	,	,	PUNCT
dti-1306	481	8	s.	s.	PROPN
dti-1306	481	9	et	et	PROPN
dti-1306	481	10	al	al	PROPN
dti-1306	481	11	.	.	PROPN
dti-1306	481	12	2001	2001	NUM
dti-1306	481	13	.	.	PUNCT
dti-1306	482	1	the	the	DET
dti-1306	482	2	angiogenesis	angiogenesis	NOUN
dti-1306	482	3	inhibitor	inhibitor	NOUN
dti-1306	482	4	tnp-470	tnp-470	NOUN
dti-1306	482	5	effectively	effectively	ADV
dti-1306	482	6	inhibits	inhibit	VERB
dti-1306	482	7	human	human	ADJ
dti-1306	482	8	neuroblastoma	neuroblastoma	ADJ
dti-1306	482	9	xenograft	xenograft	NOUN
dti-1306	482	10	growth	growth	NOUN
dti-1306	482	11	,	,	PUNCT
dti-1306	482	12	especially	especially	ADV
dti-1306	482	13	in	in	ADP
dti-1306	482	14	the	the	DET
dti-1306	482	15	setting	setting	NOUN
dti-1306	482	16	of	of	ADP
dti-1306	482	17	subclinical	subclinical	ADJ
dti-1306	482	18	disease	disease	NOUN
dti-1306	482	19	.	.	PUNCT
dti-1306	483	1	clin	clin	PROPN
dti-1306	483	2	.	.	PUNCT
dti-1306	484	1	cancer	cancer	NOUN
dti-1306	484	2	res	re	NOUN
dti-1306	484	3	.	.	PUNCT
dti-1306	484	4	,	,	PUNCT
dti-1306	484	5	7:977–84	7:977–84	PROPN
dti-1306	484	6	.	.	PUNCT
dti-1306	484	7	stupp	stupp	PROPN
dti-1306	484	8	,	,	PUNCT
dti-1306	484	9	r.	r.	PROPN
dti-1306	484	10	et	et	PROPN
dti-1306	484	11	al	al	PROPN
dti-1306	484	12	.	.	PROPN
dti-1306	484	13	2005	2005	NUM
dti-1306	484	14	.	.	PUNCT
dti-1306	485	1	radiotherapy	radiotherapy	NOUN
dti-1306	485	2	plus	plus	CCONJ
dti-1306	485	3	concomitant	concomitant	ADJ
dti-1306	485	4	and	and	CCONJ
dti-1306	485	5	adjuvant	adjuvant	ADJ
dti-1306	485	6	temozolomide	temozolomide	NOUN
dti-1306	485	7	for	for	ADP
dti-1306	485	8	glioblastoma	glioblastoma	NOUN
dti-1306	485	9	.	.	PUNCT
dti-1306	486	1	n.	n.	PROPN
dti-1306	486	2	engl	engl	PROPN
dti-1306	486	3	.	.	PUNCT
dti-1306	487	1	j.	j.	PROPN
dti-1306	487	2	med	med	PROPN
dti-1306	487	3	.	.	PROPN
dti-1306	487	4	,	,	PUNCT
dti-1306	488	1	352:987–96	352:987–96	NUM
dti-1306	488	2	.	.	PUNCT
dti-1306	489	1	takano	takano	PROPN
dti-1306	489	2	,	,	PUNCT
dti-1306	489	3	s.	s.	PROPN
dti-1306	489	4	et	et	PROPN
dti-1306	489	5	al	al	PROPN
dti-1306	489	6	.	.	PROPN
dti-1306	489	7	2004	2004	NUM
dti-1306	489	8	.	.	PUNCT
dti-1306	490	1	angiogenesis	angiogenesis	NOUN
dti-1306	490	2	and	and	CCONJ
dti-1306	490	3	antiangiogenic	antiangiogenic	ADJ
dti-1306	490	4	therapy	therapy	NOUN
dti-1306	490	5	for	for	ADP
dti-1306	490	6	malignant	malignant	ADJ
dti-1306	490	7	gliomas	glioma	NOUN
dti-1306	490	8	.	.	PUNCT
dti-1306	491	1	brain	brain	NOUN
dti-1306	491	2	tumor	tumor	NOUN
dti-1306	491	3	pathol	pathol	NOUN
dti-1306	491	4	.	.	PROPN
dti-1306	491	5	,	,	PUNCT
dti-1306	491	6	21:69–73	21:69–73	NUM
dti-1306	491	7	.	.	PUNCT
dti-1306	492	1	thomas	thomas	PROPN
dti-1306	492	2	,	,	PUNCT
dti-1306	492	3	m.	m.	NOUN
dti-1306	492	4	2003	2003	NUM
dti-1306	492	5	.	.	PUNCT
dti-1306	493	1	epidermal	epidermal	ADJ
dti-1306	493	2	growth	growth	NOUN
dti-1306	493	3	factor	factor	NOUN
dti-1306	493	4	receptor	receptor	NOUN
dti-1306	493	5	tyrosine	tyrosine	PROPN
dti-1306	493	6	kinase	kinase	PROPN
dti-1306	493	7	inhibitors	inhibitor	NOUN
dti-1306	493	8	:	:	PUNCT
dti-1306	493	9	application	application	NOUN
dti-1306	493	10	in	in	ADP
dti-1306	493	11	non	non	ADJ
dti-1306	493	12	-	-	ADJ
dti-1306	493	13	small	small	ADJ
dti-1306	493	14	cell	cell	NOUN
dti-1306	493	15	lung	lung	NOUN
dti-1306	493	16	cancer	cancer	NOUN
dti-1306	493	17	.	.	PUNCT
dti-1306	494	1	cancer	cancer	NOUN
dti-1306	494	2	nurs	nur	VERB
dti-1306	494	3	.	.	PROPN
dti-1306	494	4	,	,	PUNCT
dti-1306	494	5	26	26	NUM
dti-1306	494	6	:	:	PUNCT
dti-1306	494	7	21s–25s	21s–25s	NUM
dti-1306	494	8	.	.	PUNCT
dti-1306	495	1	weaver	weaver	NOUN
dti-1306	495	2	,	,	PUNCT
dti-1306	495	3	a.k	a.k	PROPN
dti-1306	495	4	.	.	PROPN
dti-1306	495	5	,	,	PUNCT
dti-1306	495	6	bomben	bomben	PROPN
dti-1306	495	7	,	,	PUNCT
dti-1306	495	8	v.c	v.c	PROPN
dti-1306	495	9	.	.	PROPN
dti-1306	495	10	and	and	CCONJ
dti-1306	495	11	sontheimer	sontheimer	PROPN
dti-1306	495	12	,	,	PUNCT
dti-1306	495	13	h.	h.	PROPN
dti-1306	495	14	2006	2006	NUM
dti-1306	495	15	.	.	PUNCT
dti-1306	496	1	expression	expression	NOUN
dti-1306	496	2	and	and	CCONJ
dti-1306	496	3	function	function	NOUN
dti-1306	496	4	of	of	ADP
dti-1306	496	5	calcium	calcium	NOUN
dti-1306	496	6	-	-	PUNCT
dti-1306	496	7	activated	activate	VERB
dti-1306	496	8	potassium	potassium	NOUN
dti-1306	496	9	channels	channel	NOUN
dti-1306	496	10	in	in	ADP
dti-1306	496	11	human	human	ADJ
dti-1306	496	12	glioma	glioma	NOUN
dti-1306	496	13	cells	cell	NOUN
dti-1306	496	14	.	.	PUNCT
dti-1306	497	1	glia	glia	PROPN
dti-1306	497	2	.	.	PUNCT
dti-1306	497	3	,	,	PUNCT
dti-1306	497	4	54:223–33	54:223–33	NOUN
dti-1306	497	5	.	.	PUNCT
dti-1306	498	1	weaver	weaver	PROPN
dti-1306	498	2	,	,	PUNCT
dti-1306	498	3	a.k	a.k	PROPN
dti-1306	498	4	.	.	PROPN
dti-1306	498	5	,	,	PUNCT
dti-1306	498	6	liu	liu	PROPN
dti-1306	498	7	,	,	PUNCT
dti-1306	498	8	x.	x.	NOUN
dti-1306	498	9	and	and	CCONJ
dti-1306	498	10	sontheimer	sontheimer	PROPN
dti-1306	498	11	,	,	PUNCT
dti-1306	498	12	h.	h.	PROPN
dti-1306	498	13	2004	2004	NUM
dti-1306	498	14	.	.	PUNCT
dti-1306	499	1	role	role	NOUN
dti-1306	499	2	for	for	ADP
dti-1306	499	3	calcium	calcium	NOUN
dti-1306	499	4	-	-	PUNCT
dti-1306	499	5	activated	activate	VERB
dti-1306	499	6	potassium	potassium	NOUN
dti-1306	499	7	channels	channel	NOUN
dti-1306	499	8	(	(	PUNCT
dti-1306	499	9	bk	bk	NOUN
dti-1306	499	10	)	)	PUNCT
dti-1306	499	11	in	in	ADP
dti-1306	499	12	growth	growth	NOUN
dti-1306	499	13	control	control	NOUN
dti-1306	499	14	of	of	ADP
dti-1306	499	15	human	human	ADJ
dti-1306	499	16	malignant	malignant	ADJ
dti-1306	499	17	glioma	glioma	NOUN
dti-1306	499	18	cells	cell	NOUN
dti-1306	499	19	.	.	PUNCT
dti-1306	500	1	j.	j.	PROPN
dti-1306	500	2	neurosci	neurosci	PROPN
dti-1306	500	3	.	.	PUNCT
dti-1306	501	1	res	re	NOUN
dti-1306	501	2	.	.	PROPN
dti-1306	501	3	,	,	PUNCT
dti-1306	501	4	78:224–34	78:224–34	PROPN
dti-1306	501	5	.	.	PUNCT
dti-1306	502	1	wen	wen	PROPN
dti-1306	502	2	,	,	PUNCT
dti-1306	502	3	p.y	p.y	PROPN
dti-1306	502	4	.	.	PROPN
dti-1306	502	5	et	et	PROPN
dti-1306	502	6	al	al	PROPN
dti-1306	502	7	.	.	PROPN
dti-1306	502	8	2006	2006	NUM
dti-1306	502	9	.	.	PUNCT
dti-1306	503	1	phase	phase	NOUN
dti-1306	503	2	i	i	PRON
dti-1306	503	3	/	/	SYM
dti-1306	503	4	ii	ii	PROPN
dti-1306	503	5	study	study	NOUN
dti-1306	503	6	of	of	ADP
dti-1306	503	7	imatinib	imatinib	NOUN
dti-1306	503	8	mesylate	mesylate	VERB
dti-1306	503	9	for	for	ADP
dti-1306	503	10	recurrent	recurrent	ADJ
dti-1306	503	11	malignant	malignant	ADJ
dti-1306	503	12	gliomas	glioma	NOUN
dti-1306	503	13	:	:	PUNCT
dti-1306	503	14	north	north	ADJ
dti-1306	503	15	american	american	ADJ
dti-1306	503	16	brain	brain	PROPN
dti-1306	503	17	tumor	tumor	PROPN
dti-1306	503	18	consortium	consortium	PROPN
dti-1306	503	19	study	study	NOUN
dti-1306	503	20	99–08	99–08	PROPN
dti-1306	503	21	.	.	PUNCT
dti-1306	504	1	clin	clin	PROPN
dti-1306	504	2	.	.	PUNCT
dti-1306	505	1	cancer	cancer	NOUN
dti-1306	505	2	res	re	NOUN
dti-1306	505	3	.	.	PUNCT
dti-1306	505	4	,	,	PUNCT
dti-1306	505	5	12:4899–907	12:4899–907	PROPN
dti-1306	505	6	.	.	PUNCT
dti-1306	506	1	yamanaka	yamanaka	PROPN
dti-1306	506	2	,	,	PUNCT
dti-1306	506	3	r.	r.	PROPN
dti-1306	506	4	et	et	PROPN
dti-1306	506	5	al	al	PROPN
dti-1306	506	6	.	.	PROPN
dti-1306	506	7	2003	2003	NUM
dti-1306	506	8	.	.	PUNCT
dti-1306	507	1	induction	induction	NOUN
dti-1306	507	2	of	of	ADP
dti-1306	507	3	an	an	DET
dti-1306	507	4	antitumor	antitumor	PROPN
dti-1306	507	5	immunological	immunological	ADJ
dti-1306	507	6	response	response	NOUN
dti-1306	507	7	by	by	ADP
dti-1306	507	8	an	an	DET
dti-1306	507	9	intratumoral	intratumoral	ADJ
dti-1306	507	10	injection	injection	NOUN
dti-1306	507	11	of	of	ADP
dti-1306	507	12	dendritic	dendritic	ADJ
dti-1306	507	13	cells	cell	NOUN
dti-1306	507	14	pulsed	pulse	VERB
dti-1306	507	15	with	with	ADP
dti-1306	507	16	genetically	genetically	ADV
dti-1306	507	17	engineered	engineer	VERB
dti-1306	507	18	semliki	semliki	PROPN
dti-1306	507	19	forest	forest	NOUN
dti-1306	507	20	virus	virus	NOUN
dti-1306	507	21	to	to	PART
dti-1306	507	22	produce	produce	VERB
dti-1306	507	23	interleukin-18	interleukin-18	PROPN
dti-1306	507	24	combined	combine	VERB
dti-1306	507	25	with	with	ADP
dti-1306	507	26	the	the	DET
dti-1306	507	27	systemic	systemic	ADJ
dti-1306	507	28	administration	administration	NOUN
dti-1306	507	29	of	of	ADP
dti-1306	507	30	interleukin-12	interleukin-12	PROPN
dti-1306	507	31	.	.	PUNCT
dti-1306	507	32	j.	j.	PROPN
dti-1306	507	33	neurosurg	neurosurg	PROPN
dti-1306	507	34	.	.	PUNCT
dti-1306	507	35	,	,	PUNCT
dti-1306	507	36	99:746–53	99:746–53	NOUN
dti-1306	507	37	.	.	PUNCT
dti-1306	508	1	yang	yang	PROPN
dti-1306	508	2	,	,	PUNCT
dti-1306	508	3	w.	w.	PROPN
dti-1306	508	4	et	et	PROPN
dti-1306	508	5	al	al	PROPN
dti-1306	508	6	.	.	PROPN
dti-1306	508	7	2005	2005	NUM
dti-1306	508	8	.	.	PUNCT
dti-1306	509	1	development	development	NOUN
dti-1306	509	2	of	of	ADP
dti-1306	509	3	a	a	DET
dti-1306	509	4	syngeneic	syngeneic	ADJ
dti-1306	509	5	rat	rat	NOUN
dti-1306	509	6	brain	brain	NOUN
dti-1306	509	7	tumor	tumor	NOUN
dti-1306	509	8	model	model	NOUN
dti-1306	509	9	expressing	express	VERB
dti-1306	509	10	egfrviii	egfrviii	NOUN
dti-1306	509	11	and	and	CCONJ
dti-1306	509	12	its	its	PRON
dti-1306	509	13	use	use	NOUN
dti-1306	509	14	for	for	ADP
dti-1306	509	15	molecular	molecular	ADJ
dti-1306	509	16	targeting	targeting	NOUN
dti-1306	509	17	studies	study	NOUN
dti-1306	509	18	with	with	ADP
dti-1306	509	19	monoclonal	monoclonal	NOUN
dti-1306	509	20	antibody	antibody	NOUN
dti-1306	509	21	l8a4	l8a4	NOUN
dti-1306	509	22	.	.	PUNCT
dti-1306	510	1	clin	clin	PROPN
dti-1306	510	2	.	.	PUNCT
dti-1306	511	1	cancer	cancer	NOUN
dti-1306	511	2	res	re	NOUN
dti-1306	511	3	.	.	PROPN
dti-1306	511	4	,	,	PUNCT
dti-1306	511	5	11:341–50	11:341–50	PROPN
dti-1306	511	6	.	.	PUNCT
dti-1306	512	1	yung	yung	PROPN
dti-1306	512	2	,	,	PUNCT
dti-1306	512	3	w.k	w.k	PROPN
dti-1306	512	4	.	.	PROPN
dti-1306	512	5	et	et	PROPN
dti-1306	512	6	al	al	PROPN
dti-1306	512	7	.	.	PROPN
dti-1306	512	8	1999	1999	NUM
dti-1306	512	9	.	.	PUNCT
dti-1306	513	1	multicenter	multicenter	NOUN
dti-1306	513	2	phase	phase	NOUN
dti-1306	513	3	ii	ii	NOUN
dti-1306	513	4	trial	trial	NOUN
dti-1306	513	5	of	of	ADP
dti-1306	513	6	temozolomide	temozolomide	NOUN
dti-1306	513	7	in	in	ADP
dti-1306	513	8	patients	patient	NOUN
dti-1306	513	9	with	with	ADP
dti-1306	513	10	anaplastic	anaplastic	ADJ
dti-1306	513	11	astrocytoma	astrocytoma	NOUN
dti-1306	513	12	or	or	CCONJ
dti-1306	513	13	anaplastic	anaplastic	ADJ
dti-1306	513	14	oligoastrocytoma	oligoastrocytoma	NOUN
dti-1306	513	15	at	at	ADP
dti-1306	513	16	first	first	ADJ
dti-1306	513	17	relapse	relapse	NOUN
dti-1306	513	18	.	.	PUNCT
dti-1306	514	1	temodal	temodal	ADJ
dti-1306	514	2	brain	brain	NOUN
dti-1306	514	3	tumor	tumor	NOUN
dti-1306	514	4	group	group	NOUN
dti-1306	514	5	.	.	PUNCT
dti-1306	515	1	j.	j.	PROPN
dti-1306	515	2	clin	clin	PROPN
dti-1306	515	3	.	.	PUNCT
dti-1306	516	1	oncol	oncol	PROPN
dti-1306	516	2	.	.	PUNCT
dti-1306	516	3	,	,	PUNCT
dti-1306	517	1	17:2762–71	17:2762–71	NOUN
dti-1306	517	2	.	.	PUNCT
dti-1306	518	1	zhang	zhang	PROPN
dti-1306	518	2	,	,	PUNCT
dti-1306	518	3	l.	l.	PROPN
dti-1306	518	4	and	and	CCONJ
dti-1306	518	5	coukos	coukos	PROPN
dti-1306	518	6	,	,	PUNCT
dti-1306	518	7	g.	g.	PROPN
dti-1306	518	8	2006	2006	NUM
dti-1306	518	9	.	.	PUNCT
dti-1306	519	1	micrornas	microrna	NOUN
dti-1306	519	2	:	:	PUNCT
dti-1306	519	3	a	a	DET
dti-1306	519	4	new	new	ADJ
dti-1306	519	5	insight	insight	NOUN
dti-1306	519	6	into	into	ADP
dti-1306	519	7	cancer	cancer	NOUN
dti-1306	519	8	genome	genome	NOUN
dti-1306	519	9	.	.	PUNCT
dti-1306	520	1	cell	cell	NOUN
dti-1306	520	2	cycle	cycle	NOUN
dti-1306	520	3	,	,	PUNCT
dti-1306	520	4	5:2216–19	5:2216–19	NOUN
dti-1306	520	5	.	.	PUNCT
dti-1306	521	1	<	<	X
dti-1306	521	2	<	<	X
dti-1306	521	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1306	521	4	false	false	ADJ
dti-1306	521	5	/allowtransparency	/allowtransparency	NOUN
dti-1306	521	6	false	false	ADJ
dti-1306	521	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1306	521	8	true	true	ADJ
dti-1306	521	9	/autorotatepages	/autorotatepage	NOUN
dti-1306	521	10	/none	/none	PUNCT
dti-1306	521	11	/binding	/binding	PUNCT
dti-1306	521	12	/left	/left	ADJ
dti-1306	522	1	/calgrayprofile	/calgrayprofile	VERB
dti-1306	522	2	(	(	PUNCT
dti-1306	522	3	dot	dot	NOUN
dti-1306	522	4	gain	gain	NOUN
dti-1306	522	5	20	20	NUM
dti-1306	522	6	%	%	NOUN
dti-1306	522	7	)	)	PUNCT
dti-1306	522	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1306	523	1	(	(	PUNCT
dti-1306	523	2	srgb	srgb	PROPN
dti-1306	523	3	iec61966	iec61966	NOUN
dti-1306	523	4	-	-	PUNCT
dti-1306	523	5	2.1	2.1	NUM
dti-1306	523	6	)	)	PUNCT
dti-1306	523	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1306	524	1	(	(	PUNCT
dti-1306	524	2	u.s	u.s	PROPN
dti-1306	524	3	.	.	PROPN
dti-1306	524	4	web	web	NOUN
dti-1306	524	5	coated	coat	VERB
dti-1306	524	6	\050swop\051	\050swop\051	ADJ
dti-1306	524	7	v2	v2	NOUN
dti-1306	524	8	)	)	PUNCT
dti-1306	524	9	/srgbprofile	/srgbprofile	PUNCT
dti-1306	524	10	(	(	PUNCT
dti-1306	524	11	srgb	srgb	PROPN
dti-1306	524	12	iec61966	iec61966	NOUN
dti-1306	524	13	-	-	PUNCT
dti-1306	524	14	2.1	2.1	NUM
dti-1306	524	15	)	)	PUNCT
dti-1306	524	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1306	525	1	/error	/error	INTJ
dti-1306	525	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1306	526	1	1.4	1.4	NUM
dti-1306	526	2	/compressobjects	/compressobject	NOUN
dti-1306	526	3	/tags	/tag	VERB
dti-1306	526	4	/compresspages	/compresspage	NOUN
dti-1306	526	5	true	true	ADJ
dti-1306	526	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1306	526	7	true	true	ADJ
dti-1306	526	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1306	526	9	true	true	ADJ
dti-1306	526	10	/createjdffile	/createjdffile	ADJ
dti-1306	526	11	false	false	ADJ
dti-1306	526	12	/createjobticket	/createjobticket	NOUN
dti-1306	526	13	false	false	ADJ
dti-1306	526	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1306	526	15	/default	/default	PUNCT
dti-1306	526	16	/detectblends	/detectblend	NOUN
dti-1306	526	17	true	true	ADJ
dti-1306	526	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1306	526	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1306	526	20	/dothumbnails	/dothumbnail	VERB
dti-1306	526	21	false	false	ADJ
dti-1306	526	22	/embedallfonts	/embedallfont	NOUN
dti-1306	526	23	true	true	ADJ
dti-1306	526	24	/embedjoboptions	/embedjoboption	NOUN
dti-1306	526	25	true	true	ADJ
dti-1306	526	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1306	526	27	0	0	NUM
dti-1306	526	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1306	526	29	false	false	ADJ
dti-1306	526	30	/endpage	/endpage	NOUN
dti-1306	526	31	-1	-1	NOUN
dti-1306	526	32	/imagememory	/imagememory	NUM
dti-1306	527	1	1048576	1048576	NUM
dti-1306	527	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1306	527	3	false	false	ADJ
dti-1306	527	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1306	527	5	100	100	NUM
dti-1306	527	6	/optimize	/optimize	NOUN
dti-1306	527	7	true	true	ADJ
dti-1306	527	8	/opm	/opm	NOUN
dti-1306	527	9	1	1	NUM
dti-1306	527	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1306	527	11	true	true	ADJ
dti-1306	527	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1306	527	13	true	true	ADJ
dti-1306	527	14	/preservecopypage	/preservecopypage	NOUN
dti-1306	527	15	true	true	ADJ
dti-1306	527	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1306	527	17	true	true	ADJ
dti-1306	527	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1306	527	19	false	false	ADJ
dti-1306	527	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1306	527	21	false	false	ADJ
dti-1306	527	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1306	527	23	true	true	ADJ
dti-1306	527	24	/startpage	/startpage	NOUN
dti-1306	527	25	1	1	NUM
dti-1306	527	26	/subsetfonts	/subsetfont	NOUN
dti-1306	527	27	true	true	ADJ
dti-1306	527	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1306	527	29	/apply	/apply	PUNCT
dti-1306	527	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1306	528	1	/preserve	/preserve	NOUN
dti-1306	528	2	/useprologue	/useprologue	NOUN
dti-1306	528	3	false	false	ADJ
dti-1306	528	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1306	528	5	(	(	PUNCT
dti-1306	528	6	)	)	PUNCT
dti-1306	528	7	/alwaysembed	/alwaysembe	VERB
dti-1306	528	8	[	[	PUNCT
dti-1306	528	9	true	true	ADJ
dti-1306	528	10	]	]	PUNCT
dti-1306	528	11	/neverembed	/neverembed	PUNCT
dti-1306	529	1	[	[	PUNCT
dti-1306	529	2	true	true	ADJ
dti-1306	529	3	]	]	PUNCT
dti-1306	529	4	/antialiascolorimages	/antialiascolorimages	X
dti-1306	529	5	false	false	ADJ
dti-1306	529	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1306	529	7	true	true	ADJ
dti-1306	529	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1306	529	9	/bicubic	/bicubic	NOUN
dti-1306	529	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1306	529	11	300	300	NUM
dti-1306	529	12	/colorimagedepth	/colorimagedepth	PRON
dti-1306	530	1	-1	-1	INTJ
dti-1306	530	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1306	530	3	1.50000	1.50000	NUM
dti-1306	530	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1306	530	5	true	true	ADJ
dti-1306	530	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1306	530	7	/dctencode	/dctencode	PUNCT
dti-1306	530	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1306	530	9	true	true	ADJ
dti-1306	530	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1306	530	11	/jpeg	/jpeg	PUNCT
dti-1306	530	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1306	531	1	<	<	X
dti-1306	531	2	<	<	X
dti-1306	531	3	/qfactor	/qfactor	NOUN
dti-1306	531	4	0.15	0.15	NUM
dti-1306	531	5	/hsamples	/hsample	NOUN
dti-1306	532	1	[	[	X
dti-1306	532	2	1	1	NUM
dti-1306	532	3	1	1	NUM
dti-1306	532	4	1	1	NUM
dti-1306	532	5	1	1	NUM
dti-1306	532	6	]	]	PUNCT
dti-1306	532	7	/vsamples	/vsample	NOUN
dti-1306	533	1	[	[	X
dti-1306	533	2	1	1	NUM
dti-1306	533	3	1	1	NUM
dti-1306	533	4	1	1	NUM
dti-1306	533	5	1	1	NUM
dti-1306	533	6	]	]	PUNCT
dti-1306	533	7	>	>	PUNCT
dti-1306	533	8	>	>	X
dti-1306	533	9	/colorimagedict	/colorimagedict	PUNCT
dti-1306	534	1	<	<	X
dti-1306	534	2	<	<	X
dti-1306	534	3	/qfactor	/qfactor	NOUN
dti-1306	534	4	0.15	0.15	NUM
dti-1306	534	5	/hsamples	/hsample	NOUN
dti-1306	535	1	[	[	X
dti-1306	535	2	1	1	NUM
dti-1306	535	3	1	1	NUM
dti-1306	535	4	1	1	NUM
dti-1306	535	5	1	1	NUM
dti-1306	535	6	]	]	PUNCT
dti-1306	535	7	/vsamples	/vsample	NOUN
dti-1306	536	1	[	[	X
dti-1306	536	2	1	1	NUM
dti-1306	536	3	1	1	NUM
dti-1306	536	4	1	1	NUM
dti-1306	536	5	1	1	NUM
dti-1306	536	6	]	]	PUNCT
dti-1306	536	7	>	>	PUNCT
dti-1306	536	8	>	>	X
dti-1306	536	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1306	537	1	<	<	X
dti-1306	537	2	<	<	X
dti-1306	537	3	/tilewidth	/tilewidth	PUNCT
dti-1306	537	4	256	256	NUM
dti-1306	537	5	/tileheight	/tileheight	NUM
dti-1306	537	6	256	256	NUM
dti-1306	537	7	/quality	/quality	NOUN
dti-1306	537	8	30	30	NUM
dti-1306	537	9	>	>	PUNCT
dti-1306	537	10	>	>	X
dti-1306	537	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1306	537	12	<	<	X
dti-1306	537	13	<	<	X
dti-1306	537	14	/tilewidth	/tilewidth	PUNCT
dti-1306	537	15	256	256	NUM
dti-1306	537	16	/tileheight	/tileheight	NUM
dti-1306	537	17	256	256	NUM
dti-1306	537	18	/quality	/quality	NOUN
dti-1306	537	19	30	30	NUM
dti-1306	537	20	>	>	PUNCT
dti-1306	537	21	>	>	X
dti-1306	537	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1306	537	23	false	false	ADJ
dti-1306	537	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1306	538	1	true	true	ADJ
dti-1306	538	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1306	538	3	/bicubic	/bicubic	NOUN
dti-1306	538	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1306	538	5	300	300	NUM
dti-1306	538	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1306	538	7	-1	-1	PUNCT
dti-1306	538	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1306	539	1	1.50000	1.50000	NUM
dti-1306	539	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1306	539	3	true	true	ADJ
dti-1306	539	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1306	539	5	/dctencode	/dctencode	PUNCT
dti-1306	540	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1306	540	2	true	true	ADJ
dti-1306	540	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1306	540	4	/jpeg	/jpeg	PUNCT
dti-1306	540	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1306	541	1	<	<	X
dti-1306	541	2	<	<	X
dti-1306	541	3	/qfactor	/qfactor	NOUN
dti-1306	541	4	0.15	0.15	NUM
dti-1306	541	5	/hsamples	/hsample	NOUN
dti-1306	542	1	[	[	X
dti-1306	542	2	1	1	NUM
dti-1306	542	3	1	1	NUM
dti-1306	542	4	1	1	NUM
dti-1306	542	5	1	1	NUM
dti-1306	542	6	]	]	PUNCT
dti-1306	542	7	/vsamples	/vsample	NOUN
dti-1306	543	1	[	[	X
dti-1306	543	2	1	1	NUM
dti-1306	543	3	1	1	NUM
dti-1306	543	4	1	1	NUM
dti-1306	543	5	1	1	NUM
dti-1306	543	6	]	]	PUNCT
dti-1306	543	7	>	>	PUNCT
dti-1306	543	8	>	>	X
dti-1306	543	9	/grayimagedict	/grayimagedict	PUNCT
dti-1306	544	1	<	<	X
dti-1306	544	2	<	<	X
dti-1306	544	3	/qfactor	/qfactor	NOUN
dti-1306	544	4	0.15	0.15	NUM
dti-1306	544	5	/hsamples	/hsample	NOUN
dti-1306	545	1	[	[	X
dti-1306	545	2	1	1	NUM
dti-1306	545	3	1	1	NUM
dti-1306	545	4	1	1	NUM
dti-1306	545	5	1	1	NUM
dti-1306	545	6	]	]	PUNCT
dti-1306	545	7	/vsamples	/vsample	NOUN
dti-1306	546	1	[	[	X
dti-1306	546	2	1	1	NUM
dti-1306	546	3	1	1	NUM
dti-1306	546	4	1	1	NUM
dti-1306	546	5	1	1	NUM
dti-1306	546	6	]	]	PUNCT
dti-1306	546	7	>	>	X
dti-1306	546	8	>	>	X
dti-1306	546	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1306	547	1	<	<	X
dti-1306	547	2	<	<	X
dti-1306	547	3	/tilewidth	/tilewidth	PUNCT
dti-1306	547	4	256	256	NUM
dti-1306	547	5	/tileheight	/tileheight	NUM
dti-1306	547	6	256	256	NUM
dti-1306	547	7	/quality	/quality	NOUN
dti-1306	547	8	30	30	NUM
dti-1306	547	9	>	>	PUNCT
dti-1306	547	10	>	>	X
dti-1306	547	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1306	547	12	<	<	X
dti-1306	547	13	<	<	X
dti-1306	547	14	/tilewidth	/tilewidth	PUNCT
dti-1306	547	15	256	256	NUM
dti-1306	547	16	/tileheight	/tileheight	NUM
dti-1306	547	17	256	256	NUM
dti-1306	547	18	/quality	/quality	NOUN
dti-1306	547	19	30	30	NUM
dti-1306	547	20	>	>	PUNCT
dti-1306	547	21	>	>	X
dti-1306	547	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1306	547	23	false	false	ADJ
dti-1306	547	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1306	547	25	true	true	ADJ
dti-1306	547	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1306	547	27	/bicubic	/bicubic	NOUN
dti-1306	547	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1306	547	29	1200	1200	NUM
dti-1306	547	30	/monoimagedepth	/monoimagedepth	PRON
dti-1306	547	31	-1	-1	PUNCT
dti-1306	547	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1306	547	33	1.50000	1.50000	NUM
dti-1306	547	34	/encodemonoimages	/encodemonoimage	NOUN
dti-1306	547	35	true	true	ADJ
dti-1306	547	36	/monoimagefilter	/monoimagefilter	ADP
dti-1306	547	37	/ccittfaxencode	/ccittfaxencode	INTJ
dti-1306	547	38	/monoimagedict	/monoimagedict	PUNCT
dti-1306	548	1	<	<	X
dti-1306	548	2	<	<	X
dti-1306	548	3	/k	/k	PUNCT
dti-1306	548	4	-1	-1	INTJ
dti-1306	548	5	>	>	PUNCT
dti-1306	548	6	>	>	X
dti-1306	548	7	/allowpsxobjects	/allowpsxobject	NOUN
dti-1306	549	1	false	false	ADJ
dti-1306	549	2	/pdfx1acheck	/pdfx1acheck	X
dti-1306	549	3	false	false	ADJ
dti-1306	549	4	/pdfx3check	/pdfx3check	PUNCT
dti-1306	549	5	false	false	ADJ
dti-1306	549	6	/pdfxcompliantpdfonly	/pdfxcompliantpdfonly	ADV
dti-1306	549	7	false	false	ADJ
dti-1306	549	8	/pdfxnotrimboxerror	/pdfxnotrimboxerror	NOUN
dti-1306	549	9	true	true	ADJ
dti-1306	549	10	/pdfxtrimboxtomediaboxoffset	/pdfxtrimboxtomediaboxoffset	NOUN
dti-1306	549	11	[	[	PUNCT
dti-1306	549	12	0.00000	0.00000	NUM
dti-1306	549	13	0.00000	0.00000	NUM
dti-1306	549	14	0.00000	0.00000	NUM
dti-1306	549	15	0.00000	0.00000	NUM
dti-1306	549	16	]	]	PUNCT
dti-1306	549	17	/pdfxsetbleedboxtomediabox	/pdfxsetbleedboxtomediabox	PUNCT
dti-1306	550	1	true	true	ADJ
dti-1306	550	2	/pdfxbleedboxtotrimboxoffset	/pdfxbleedboxtotrimboxoffset	PUNCT
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dti-1306	562	4	/enu	/enu	PROPN
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dti-1306	562	12	setdistillerparams	setdistillerparam	NOUN
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dti-1306	563	3	/hwresolution	/hwresolution	NOUN
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dti-1306	565	7	setpagedevice	setpagedevice	PROPN