id	sid	tid	token	lemma	pos
dti-1314	1	1	savaraj	savaraj	VERB
dti-1314	1	2	et	et	PROPN
dti-1314	1	3	al.indd	al.indd	PUNCT
dti-1314	1	4	drug	drug	NOUN
dti-1314	1	5	target	target	NOUN
dti-1314	1	6	insights	insight	NOUN
dti-1314	1	7	2007	2007	NUM
dti-1314	1	8	:	:	PUNCT
dti-1314	1	9	2	2	NUM
dti-1314	1	10	119–128	119–128	NUM
dti-1314	1	11	119	119	NUM
dti-1314	1	12	review	review	VERB
dti-1314	1	13	the	the	DET
dti-1314	1	14	relationship	relationship	NOUN
dti-1314	1	15	of	of	ADP
dti-1314	1	16	arginine	arginine	NOUN
dti-1314	1	17	deprivation	deprivation	NOUN
dti-1314	1	18	,	,	PUNCT
dti-1314	1	19	argininosuccinate	argininosuccinate	NOUN
dti-1314	1	20	synthetase	synthetase	NOUN
dti-1314	1	21	and	and	CCONJ
dti-1314	1	22	cell	cell	NOUN
dti-1314	1	23	death	death	NOUN
dti-1314	1	24	in	in	ADP
dti-1314	1	25	melanoma	melanoma	NOUN
dti-1314	1	26	niramol	niramol	ADJ
dti-1314	1	27	savaraj1	savaraj1	NOUN
dti-1314	1	28	,	,	PUNCT
dti-1314	1	29	chunjing	chunje	VERB
dti-1314	1	30	wu2	wu2	PROPN
dti-1314	1	31	,	,	PUNCT
dti-1314	1	32	marcus	marcus	PROPN
dti-1314	1	33	tien	tien	PROPN
dti-1314	1	34	kuo3	kuo3	PROPN
dti-1314	1	35	,	,	PUNCT
dti-1314	1	36	min	min	PROPN
dti-1314	1	37	you2	you2	PROPN
dti-1314	1	38	,	,	PUNCT
dti-1314	1	39	medhi	medhi	VERB
dti-1314	1	40	wangpaichitr2	wangpaichitr2	PROPN
dti-1314	1	41	,	,	PUNCT
dti-1314	1	42	carlos	carlos	PROPN
dti-1314	1	43	robles1	robles1	PROPN
dti-1314	1	44	,	,	PUNCT
dti-1314	1	45	seth	seth	PROPN
dti-1314	1	46	spector1	spector1	PROPN
dti-1314	1	47	and	and	CCONJ
dti-1314	1	48	lynn	lynn	PROPN
dti-1314	2	1	feun2	feun2	PROPN
dti-1314	2	2	1va	1va	PROPN
dti-1314	2	3	medical	medical	ADJ
dti-1314	2	4	center	center	NOUN
dti-1314	2	5	,	,	PUNCT
dti-1314	2	6	hematology	hematology	NOUN
dti-1314	2	7	-	-	PUNCT
dti-1314	2	8	oncology	oncology	NOUN
dti-1314	2	9	,	,	PUNCT
dti-1314	2	10	miami	miami	PROPN
dti-1314	2	11	,	,	PUNCT
dti-1314	2	12	florida	florida	PROPN
dti-1314	2	13	,	,	PUNCT
dti-1314	2	14	u.s.a	u.s.a	PROPN
dti-1314	2	15	.	.	PUNCT
dti-1314	3	1	2university	2university	NUM
dti-1314	3	2	of	of	ADP
dti-1314	3	3	miami	miami	PROPN
dti-1314	3	4	,	,	PUNCT
dti-1314	3	5	hematology	hematology	NOUN
dti-1314	3	6	-	-	PUNCT
dti-1314	3	7	oncology	oncology	NOUN
dti-1314	3	8	,	,	PUNCT
dti-1314	3	9	miami	miami	PROPN
dti-1314	3	10	,	,	PUNCT
dti-1314	3	11	florida	florida	PROPN
dti-1314	3	12	,	,	PUNCT
dti-1314	3	13	u.s.a	u.s.a	PROPN
dti-1314	3	14	.	.	PUNCT
dti-1314	3	15	3m.d	3m.d	NUM
dti-1314	3	16	.	.	PUNCT
dti-1314	4	1	anderson	anderson	PROPN
dti-1314	4	2	cancer	cancer	PROPN
dti-1314	4	3	center	center	PROPN
dti-1314	4	4	,	,	PUNCT
dti-1314	4	5	molecular	molecular	ADJ
dti-1314	4	6	pathology	pathology	NOUN
dti-1314	4	7	,	,	PUNCT
dti-1314	4	8	houston	houston	PROPN
dti-1314	4	9	,	,	PUNCT
dti-1314	4	10	texas	texas	PROPN
dti-1314	4	11	,	,	PUNCT
dti-1314	4	12	u.s.a	u.s.a	PROPN
dti-1314	4	13	.	.	PUNCT
dti-1314	4	14	abstract	abstract	PROPN
dti-1314	4	15	:	:	PUNCT
dti-1314	4	16	it	it	PRON
dti-1314	4	17	has	have	AUX
dti-1314	4	18	been	be	AUX
dti-1314	4	19	shown	show	VERB
dti-1314	4	20	that	that	SCONJ
dti-1314	4	21	melanoma	melanoma	NOUN
dti-1314	4	22	cells	cell	NOUN
dti-1314	4	23	do	do	AUX
dti-1314	4	24	not	not	PART
dti-1314	4	25	express	express	VERB
dti-1314	4	26	argininosuccinate	argininosuccinate	NOUN
dti-1314	4	27	synthetase	synthetase	NOUN
dti-1314	4	28	(	(	PUNCT
dti-1314	4	29	ass	ass	NOUN
dti-1314	4	30	)	)	PUNCT
dti-1314	4	31	and	and	CCONJ
dti-1314	4	32	therefore	therefore	ADV
dti-1314	4	33	are	be	AUX
dti-1314	4	34	unable	unable	ADJ
dti-1314	4	35	to	to	PART
dti-1314	4	36	synthesize	synthesize	VERB
dti-1314	4	37	arginine	arginine	NOUN
dti-1314	4	38	from	from	ADP
dti-1314	4	39	citrulline	citrulline	NOUN
dti-1314	4	40	.	.	PUNCT
dti-1314	5	1	depleting	deplete	VERB
dti-1314	5	2	arginine	arginine	NOUN
dti-1314	5	3	using	use	VERB
dti-1314	5	4	pegylated	pegylate	VERB
dti-1314	5	5	arginine	arginine	NOUN
dti-1314	5	6	deiminase	deiminase	NOUN
dti-1314	5	7	(	(	PUNCT
dti-1314	5	8	adi	adi	NOUN
dti-1314	5	9	-	-	PUNCT
dti-1314	5	10	peg20	peg20	PROPN
dti-1314	5	11	)	)	PUNCT
dti-1314	5	12	results	result	NOUN
dti-1314	5	13	in	in	ADP
dti-1314	5	14	cell	cell	NOUN
dti-1314	5	15	death	death	NOUN
dti-1314	5	16	in	in	ADP
dti-1314	5	17	melanoma	melanoma	NOUN
dti-1314	5	18	but	but	CCONJ
dti-1314	5	19	not	not	PART
dti-1314	5	20	normal	normal	ADJ
dti-1314	5	21	cells	cell	NOUN
dti-1314	5	22	.	.	PUNCT
dti-1314	6	1	this	this	DET
dti-1314	6	2	concept	concept	NOUN
dti-1314	6	3	was	be	AUX
dti-1314	6	4	translated	translate	VERB
dti-1314	6	5	into	into	ADP
dti-1314	6	6	clinical	clinical	ADJ
dti-1314	6	7	trial	trial	NOUN
dti-1314	6	8	and	and	CCONJ
dti-1314	6	9	responses	response	NOUN
dti-1314	6	10	were	be	AUX
dti-1314	6	11	seen	see	VERB
dti-1314	6	12	.	.	PUNCT
dti-1314	7	1	however	however	ADV
dti-1314	7	2	,	,	PUNCT
dti-1314	7	3	induction	induction	NOUN
dti-1314	7	4	of	of	ADP
dti-1314	7	5	ass	ass	NOUN
dti-1314	7	6	expression	expression	NOUN
dti-1314	7	7	does	do	AUX
dti-1314	7	8	occur	occur	VERB
dti-1314	7	9	which	which	PRON
dti-1314	7	10	results	result	VERB
dti-1314	7	11	in	in	ADP
dti-1314	7	12	resistance	resistance	NOUN
dti-1314	7	13	to	to	ADP
dti-1314	7	14	adi	adi	PROPN
dti-1314	7	15	-peg20	-peg20	PROPN
dti-1314	7	16	.	.	PUNCT
dti-1314	8	1	we	we	PRON
dti-1314	8	2	have	have	AUX
dti-1314	8	3	used	use	VERB
dti-1314	8	4	4	4	NUM
dti-1314	8	5	melanoma	melanoma	NOUN
dti-1314	8	6	cell	cell	NOUN
dti-1314	8	7	lines	line	NOUN
dti-1314	8	8	to	to	PART
dti-1314	8	9	study	study	VERB
dti-1314	8	10	factors	factor	NOUN
dti-1314	8	11	which	which	PRON
dti-1314	8	12	may	may	AUX
dti-1314	8	13	govern	govern	VERB
dti-1314	8	14	ass	ass	NOUN
dti-1314	8	15	expression	expression	NOUN
dti-1314	8	16	.	.	PUNCT
dti-1314	9	1	although	although	SCONJ
dti-1314	9	2	these	these	DET
dti-1314	9	3	4	4	NUM
dti-1314	9	4	melanoma	melanoma	NOUN
dti-1314	9	5	cell	cell	NOUN
dti-1314	9	6	lines	line	NOUN
dti-1314	9	7	do	do	AUX
dti-1314	9	8	not	not	PART
dti-1314	9	9	express	express	VERB
dti-1314	9	10	ass	ass	NOUN
dti-1314	9	11	protein	protein	NOUN
dti-1314	9	12	or	or	CCONJ
dti-1314	9	13	mrna	mrna	NOUN
dti-1314	9	14	as	as	SCONJ
dti-1314	9	15	detected	detect	VERB
dti-1314	9	16	by	by	ADP
dti-1314	9	17	both	both	DET
dti-1314	9	18	immunoblot	immunoblot	NOUN
dti-1314	9	19	and	and	CCONJ
dti-1314	9	20	northernblot	northernblot	ADJ
dti-1314	9	21	analysis	analysis	NOUN
dti-1314	9	22	,	,	PUNCT
dti-1314	9	23	ass	ass	NOUN
dti-1314	9	24	protein	protein	NOUN
dti-1314	9	25	can	can	AUX
dti-1314	9	26	be	be	AUX
dti-1314	9	27	induced	induce	VERB
dti-1314	9	28	after	after	SCONJ
dti-1314	9	29	these	these	DET
dti-1314	9	30	cells	cell	NOUN
dti-1314	9	31	are	be	AUX
dti-1314	9	32	grown	grow	VERB
dti-1314	9	33	in	in	ADP
dti-1314	9	34	the	the	DET
dti-1314	9	35	presence	presence	NOUN
dti-1314	9	36	of	of	ADP
dti-1314	9	37	adi	adi	PROPN
dti-1314	9	38	-	-	PUNCT
dti-1314	9	39	peg20	peg20	PROPN
dti-1314	9	40	,	,	PUNCT
dti-1314	9	41	but	but	CCONJ
dti-1314	9	42	again	again	ADV
dti-1314	9	43	repressed	repress	VERB
dti-1314	9	44	after	after	ADP
dti-1314	9	45	replenishing	replenish	VERB
dti-1314	9	46	arginine	arginine	NOUN
dti-1314	9	47	in	in	ADP
dti-1314	9	48	the	the	DET
dti-1314	9	49	media	medium	NOUN
dti-1314	9	50	.	.	PUNCT
dti-1314	10	1	the	the	DET
dti-1314	10	2	levels	level	NOUN
dti-1314	10	3	of	of	ADP
dti-1314	10	4	induction	induction	NOUN
dti-1314	10	5	are	be	AUX
dti-1314	10	6	different	different	ADJ
dti-1314	10	7	and	and	CCONJ
dti-1314	10	8	one	one	NUM
dti-1314	10	9	cell	cell	NOUN
dti-1314	10	10	line	line	NOUN
dti-1314	10	11	could	could	AUX
dti-1314	10	12	not	not	PART
dti-1314	10	13	be	be	AUX
dti-1314	10	14	induced	induce	VERB
dti-1314	10	15	.	.	PUNCT
dti-1314	11	1	interestingly	interestingly	ADV
dti-1314	11	2	,	,	PUNCT
dti-1314	11	3	a	a	DET
dti-1314	11	4	melanoma	melanoma	NOUN
dti-1314	11	5	cell	cell	NOUN
dti-1314	11	6	line	line	NOUN
dti-1314	11	7	with	with	ADP
dti-1314	11	8	the	the	DET
dti-1314	11	9	highest	high	ADJ
dti-1314	11	10	level	level	NOUN
dti-1314	11	11	of	of	ADP
dti-1314	11	12	induction	induction	NOUN
dti-1314	11	13	could	could	AUX
dti-1314	11	14	also	also	ADV
dti-1314	11	15	be	be	AUX
dti-1314	11	16	made	make	VERB
dti-1314	11	17	resistant	resistant	ADJ
dti-1314	11	18	to	to	ADP
dti-1314	11	19	adi	adi	NOUN
dti-1314	11	20	-	-	PUNCT
dti-1314	11	21	peg20	peg20	PROPN
dti-1314	11	22	.	.	PUNCT
dti-1314	12	1	this	this	DET
dti-1314	12	2	resistant	resistant	ADJ
dti-1314	12	3	line	line	NOUN
dti-1314	12	4	possesses	possess	VERB
dti-1314	12	5	high	high	ADJ
dti-1314	12	6	levels	level	NOUN
dti-1314	12	7	of	of	ADP
dti-1314	12	8	ass	ass	PROPN
dti-1314	12	9	mrna	mrna	NOUN
dti-1314	12	10	and	and	CCONJ
dti-1314	12	11	protein	protein	NOUN
dti-1314	12	12	expression	expression	NOUN
dti-1314	12	13	which	which	PRON
dti-1314	12	14	can	can	AUX
dti-1314	12	15	not	not	PART
dti-1314	12	16	be	be	AUX
dti-1314	12	17	repressed	repress	VERB
dti-1314	12	18	with	with	ADP
dti-1314	12	19	arginine	arginine	NOUN
dti-1314	12	20	.	.	PUNCT
dti-1314	13	1	our	our	PRON
dti-1314	13	2	study	study	NOUN
dti-1314	13	3	indicates	indicate	VERB
dti-1314	13	4	that	that	SCONJ
dti-1314	13	5	ass	ass	NOUN
dti-1314	13	6	expression	expression	NOUN
dti-1314	13	7	in	in	ADP
dti-1314	13	8	melanoma	melanoma	NOUN
dti-1314	13	9	cells	cell	NOUN
dti-1314	13	10	is	be	AUX
dti-1314	13	11	complex	complex	ADJ
dti-1314	13	12	and	and	CCONJ
dti-1314	13	13	governed	govern	VERB
dti-1314	13	14	by	by	ADP
dti-1314	13	15	biochemical	biochemical	ADJ
dti-1314	13	16	parameters	parameter	NOUN
dti-1314	13	17	which	which	PRON
dti-1314	13	18	are	be	AUX
dti-1314	13	19	different	different	ADJ
dti-1314	13	20	among	among	ADP
dti-1314	13	21	melanoma	melanoma	NOUN
dti-1314	13	22	cells	cell	NOUN
dti-1314	13	23	.	.	PUNCT
dti-1314	14	1	keywords	keyword	NOUN
dti-1314	14	2	:	:	PUNCT
dti-1314	14	3	melanoma	melanoma	NOUN
dti-1314	14	4	,	,	PUNCT
dti-1314	14	5	arginine	arginine	NOUN
dti-1314	14	6	deiminase	deiminase	NOUN
dti-1314	14	7	,	,	PUNCT
dti-1314	14	8	argininosuccinate	argininosuccinate	ADJ
dti-1314	14	9	synthetase	synthetase	NOUN
dti-1314	14	10	.	.	PUNCT
dti-1314	15	1	introduction	introduction	NOUN
dti-1314	15	2	treatment	treatment	NOUN
dti-1314	15	3	of	of	ADP
dti-1314	15	4	advanced	advanced	ADJ
dti-1314	15	5	malignant	malignant	ADJ
dti-1314	15	6	melanoma	melanoma	NOUN
dti-1314	15	7	has	have	AUX
dti-1314	15	8	not	not	PART
dti-1314	15	9	signifi	signifi	AUX
dti-1314	15	10	cantly	cantly	ADV
dti-1314	15	11	improved	improve	VERB
dti-1314	15	12	in	in	ADP
dti-1314	15	13	the	the	DET
dti-1314	15	14	past	past	ADJ
dti-1314	15	15	20	20	NUM
dti-1314	15	16	years	year	NOUN
dti-1314	15	17	.	.	PUNCT
dti-1314	16	1	most	most	ADJ
dti-1314	16	2	chemotherapeutic	chemotherapeutic	ADJ
dti-1314	16	3	agents	agent	NOUN
dti-1314	16	4	have	have	VERB
dti-1314	16	5	response	response	NOUN
dti-1314	16	6	rates	rate	NOUN
dti-1314	16	7	of	of	ADP
dti-1314	16	8	15–20	15–20	NUM
dti-1314	16	9	%	%	NOUN
dti-1314	16	10	or	or	CCONJ
dti-1314	16	11	less	less	ADJ
dti-1314	16	12	(	(	PUNCT
dti-1314	16	13	devita	devita	PROPN
dti-1314	16	14	et	et	PROPN
dti-1314	16	15	al	al	PROPN
dti-1314	16	16	.	.	PROPN
dti-1314	16	17	2001	2001	NUM
dti-1314	16	18	)	)	PUNCT
dti-1314	16	19	.	.	PUNCT
dti-1314	17	1	immunotherapeutic	immunotherapeutic	ADJ
dti-1314	17	2	agents	agent	NOUN
dti-1314	17	3	including	include	VERB
dti-1314	17	4	interleukin-2	interleukin-2	NOUN
dti-1314	17	5	,	,	PUNCT
dti-1314	17	6	adoptive	adoptive	ADJ
dti-1314	17	7	immunotherapy	immunotherapy	NOUN
dti-1314	17	8	,	,	PUNCT
dti-1314	17	9	interferon	interferon	ADJ
dti-1314	17	10	alpha	alpha	NOUN
dti-1314	17	11	and	and	CCONJ
dti-1314	17	12	vaccine	vaccine	NOUN
dti-1314	17	13	therapy	therapy	NOUN
dti-1314	17	14	may	may	AUX
dti-1314	17	15	produce	produce	VERB
dti-1314	17	16	signifi	signifi	NOUN
dti-1314	17	17	ca	can	AUX
dti-1314	17	18	nt	not	PART
dti-1314	17	19	responses	response	NOUN
dti-1314	17	20	in	in	ADP
dti-1314	17	21	a	a	DET
dti-1314	17	22	very	very	ADV
dti-1314	17	23	small	small	ADJ
dti-1314	17	24	subset	subset	NOUN
dti-1314	17	25	of	of	ADP
dti-1314	17	26	patients	patient	NOUN
dti-1314	17	27	,	,	PUNCT
dti-1314	17	28	but	but	CCONJ
dti-1314	17	29	their	their	PRON
dti-1314	17	30	overall	overall	ADJ
dti-1314	17	31	response	response	NOUN
dti-1314	17	32	rate	rate	NOUN
dti-1314	17	33	is	be	AUX
dti-1314	17	34	not	not	PART
dti-1314	17	35	better	well	ADJ
dti-1314	17	36	than	than	ADP
dti-1314	17	37	chemotherapy	chemotherapy	NOUN
dti-1314	17	38	(	(	PUNCT
dti-1314	17	39	brinckerhoff	brinckerhoff	NOUN
dti-1314	17	40	et	et	PROPN
dti-1314	17	41	al	al	PROPN
dti-1314	17	42	.	.	PROPN
dti-1314	17	43	2000	2000	NUM
dti-1314	17	44	;	;	PUNCT
dti-1314	17	45	riker	riker	PROPN
dti-1314	17	46	et	et	PROPN
dti-1314	17	47	al	al	PROPN
dti-1314	17	48	.	.	PROPN
dti-1314	17	49	2007	2007	NUM
dti-1314	17	50	)	)	PUNCT
dti-1314	17	51	.	.	PUNCT
dti-1314	18	1	combinations	combination	NOUN
dti-1314	18	2	of	of	ADP
dti-1314	18	3	chemotherapy	chemotherapy	NOUN
dti-1314	18	4	and	and	CCONJ
dti-1314	18	5	immunotherapy	immunotherapy	NOUN
dti-1314	18	6	also	also	ADV
dti-1314	18	7	have	have	AUX
dti-1314	18	8	not	not	PART
dti-1314	18	9	produced	produce	VERB
dti-1314	18	10	signifi	signifi	NOUN
dti-1314	18	11	ca	can	AUX
dti-1314	18	12	nt	not	PART
dti-1314	18	13	response	response	VERB
dti-1314	18	14	rates	rate	NOUN
dti-1314	18	15	in	in	ADP
dti-1314	18	16	randomized	randomized	ADJ
dti-1314	18	17	trials	trial	NOUN
dti-1314	18	18	(	(	PUNCT
dti-1314	18	19	keilholz	keilholz	PROPN
dti-1314	18	20	and	and	CCONJ
dti-1314	18	21	gore	gore	PROPN
dti-1314	18	22	,	,	PUNCT
dti-1314	18	23	2002	2002	NUM
dti-1314	18	24	;	;	PUNCT
dti-1314	18	25	punt	punt	VERB
dti-1314	18	26	et	et	PROPN
dti-1314	18	27	al	al	PROPN
dti-1314	18	28	.	.	PROPN
dti-1314	18	29	2006	2006	NUM
dti-1314	18	30	;	;	PUNCT
dti-1314	18	31	sasse	sasse	NOUN
dti-1314	18	32	et	et	PROPN
dti-1314	18	33	al	al	PROPN
dti-1314	18	34	.	.	PROPN
dti-1314	18	35	2007	2007	NUM
dti-1314	18	36	)	)	PUNCT
dti-1314	18	37	.	.	PUNCT
dti-1314	19	1	recently	recently	ADV
dti-1314	19	2	,	,	PUNCT
dti-1314	19	3	blocking	block	VERB
dti-1314	19	4	of	of	ADP
dti-1314	19	5	raf	raf	PROPN
dti-1314	19	6	signaling	signal	VERB
dti-1314	19	7	has	have	AUX
dti-1314	19	8	been	be	AUX
dti-1314	19	9	explored	explore	VERB
dti-1314	19	10	for	for	ADP
dti-1314	19	11	the	the	DET
dti-1314	19	12	treatment	treatment	NOUN
dti-1314	19	13	of	of	ADP
dti-1314	19	14	melanoma	melanoma	NOUN
dti-1314	19	15	(	(	PUNCT
dti-1314	19	16	alsina	alsina	PROPN
dti-1314	19	17	et	et	PROPN
dti-1314	19	18	al	al	PROPN
dti-1314	19	19	.	.	PROPN
dti-1314	19	20	2003	2003	NUM
dti-1314	19	21	;	;	PUNCT
dti-1314	19	22	hoefl	hoefl	VERB
dti-1314	19	23	ich	ich	PROPN
dti-1314	19	24	et	et	PROPN
dti-1314	19	25	al	al	PROPN
dti-1314	19	26	.	.	PROPN
dti-1314	19	27	2006	2006	NUM
dti-1314	19	28	;	;	PUNCT
dti-1314	19	29	scott	scott	PROPN
dti-1314	19	30	et	et	PROPN
dti-1314	19	31	al	al	PROPN
dti-1314	19	32	.	.	PROPN
dti-1314	19	33	2000	2000	NUM
dti-1314	19	34	;	;	PUNCT
dti-1314	19	35	sridhar	sridhar	VERB
dti-1314	19	36	et	et	PROPN
dti-1314	19	37	al	al	PROPN
dti-1314	19	38	.	.	PROPN
dti-1314	19	39	2005	2005	NUM
dti-1314	19	40	)	)	PUNCT
dti-1314	19	41	,	,	PUNCT
dti-1314	19	42	however	however	ADV
dti-1314	19	43	,	,	PUNCT
dti-1314	19	44	the	the	DET
dti-1314	19	45	fi	fi	NOUN
dti-1314	19	46	rst	rst	ADJ
dti-1314	19	47	generation	generation	NOUN
dti-1314	19	48	of	of	ADP
dti-1314	19	49	raf	raf	PROPN
dti-1314	19	50	inhibitors	inhibitor	NOUN
dti-1314	19	51	such	such	ADJ
dti-1314	19	52	as	as	ADP
dti-1314	19	53	sorafenib	sorafenib	NOUN
dti-1314	19	54	has	have	AUX
dti-1314	19	55	not	not	PART
dti-1314	19	56	shown	show	VERB
dti-1314	19	57	signifi	signifi	NOUN
dti-1314	19	58	ca	can	AUX
dti-1314	19	59	nt	not	PART
dti-1314	19	60	antitumor	antitumor	VERB
dti-1314	19	61	activity	activity	NOUN
dti-1314	19	62	in	in	ADP
dti-1314	19	63	malignant	malignant	ADJ
dti-1314	19	64	melanoma	melanoma	NOUN
dti-1314	19	65	.	.	PUNCT
dti-1314	20	1	thus	thus	ADV
dti-1314	20	2	,	,	PUNCT
dti-1314	20	3	new	new	ADJ
dti-1314	20	4	effective	effective	ADJ
dti-1314	20	5	agents	agent	NOUN
dti-1314	20	6	are	be	AUX
dti-1314	20	7	needed	need	VERB
dti-1314	20	8	for	for	ADP
dti-1314	20	9	the	the	DET
dti-1314	20	10	treatment	treatment	NOUN
dti-1314	20	11	of	of	ADP
dti-1314	20	12	this	this	DET
dti-1314	20	13	disease	disease	NOUN
dti-1314	20	14	.	.	PUNCT
dti-1314	21	1	we	we	PRON
dti-1314	21	2	and	and	CCONJ
dti-1314	21	3	others	other	NOUN
dti-1314	21	4	have	have	AUX
dti-1314	21	5	shown	show	VERB
dti-1314	21	6	that	that	SCONJ
dti-1314	21	7	melanoma	melanoma	NOUN
dti-1314	21	8	cell	cell	NOUN
dti-1314	21	9	lines	line	NOUN
dti-1314	21	10	do	do	AUX
dti-1314	21	11	not	not	PART
dti-1314	21	12	express	express	VERB
dti-1314	21	13	argininosuccinate	argininosuccinate	NOUN
dti-1314	21	14	synthetase	synthetase	NOUN
dti-1314	21	15	(	(	PUNCT
dti-1314	21	16	ass	ass	PROPN
dti-1314	21	17	)	)	PUNCT
dti-1314	21	18	(	(	PUNCT
dti-1314	21	19	ensor	ensor	PROPN
dti-1314	21	20	et	et	PROPN
dti-1314	21	21	al	al	PROPN
dti-1314	21	22	.	.	PROPN
dti-1314	21	23	2002	2002	NUM
dti-1314	21	24	;	;	PUNCT
dti-1314	21	25	feun	feun	VERB
dti-1314	21	26	and	and	CCONJ
dti-1314	21	27	savaraj	savaraj	ADJ
dti-1314	21	28	,	,	PUNCT
dti-1314	21	29	2006	2006	NUM
dti-1314	21	30	;	;	PUNCT
dti-1314	21	31	scott	scott	PROPN
dti-1314	21	32	et	et	PROPN
dti-1314	21	33	al	al	PROPN
dti-1314	21	34	.	.	PROPN
dti-1314	21	35	2000	2000	NUM
dti-1314	21	36	;	;	PUNCT
dti-1314	21	37	shen	shen	PROPN
dti-1314	21	38	et	et	PROPN
dti-1314	21	39	al	al	PROPN
dti-1314	21	40	.	.	PROPN
dti-1314	21	41	2006	2006	NUM
dti-1314	21	42	;	;	PUNCT
dti-1314	21	43	wheatley	wheatley	PROPN
dti-1314	21	44	,	,	PUNCT
dti-1314	21	45	2005	2005	NUM
dti-1314	21	46	;	;	PUNCT
dti-1314	21	47	wheatley	wheatley	PROPN
dti-1314	21	48	and	and	CCONJ
dti-1314	21	49	campbell	campbell	PROPN
dti-1314	21	50	,	,	PUNCT
dti-1314	21	51	2002	2002	NUM
dti-1314	21	52	;	;	PUNCT
dti-1314	21	53	wheatley	wheatley	PROPN
dti-1314	21	54	and	and	CCONJ
dti-1314	21	55	campbell	campbell	PROPN
dti-1314	21	56	,	,	PUNCT
dti-1314	21	57	2003	2003	NUM
dti-1314	21	58	)	)	PUNCT
dti-1314	21	59	a	a	DET
dti-1314	21	60	key	key	ADJ
dti-1314	21	61	enzyme	enzyme	NOUN
dti-1314	21	62	which	which	PRON
dti-1314	21	63	converts	convert	VERB
dti-1314	21	64	citrulline	citrulline	NOUN
dti-1314	21	65	to	to	PART
dti-1314	21	66	argininosuccinate	argininosuccinate	VERB
dti-1314	21	67	.	.	PUNCT
dti-1314	22	1	argininosuccinate	argininosuccinate	NOUN
dti-1314	22	2	is	be	AUX
dti-1314	22	3	then	then	ADV
dti-1314	22	4	converted	convert	VERB
dti-1314	22	5	to	to	ADP
dti-1314	22	6	arginine	arginine	NOUN
dti-1314	22	7	by	by	ADP
dti-1314	22	8	argininosuccinate	argininosuccinate	NOUN
dti-1314	22	9	lyase	lyase	NOUN
dti-1314	22	10	.	.	PUNCT
dti-1314	23	1	thus	thus	ADV
dti-1314	23	2	,	,	PUNCT
dti-1314	23	3	melanoma	melanoma	NOUN
dti-1314	23	4	cells	cell	NOUN
dti-1314	23	5	are	be	AUX
dti-1314	23	6	particularly	particularly	ADV
dti-1314	23	7	vulnerable	vulnerable	ADJ
dti-1314	23	8	to	to	ADP
dti-1314	23	9	arginine	arginine	NOUN
dti-1314	23	10	depletion	depletion	NOUN
dti-1314	23	11	while	while	SCONJ
dti-1314	23	12	normal	normal	ADJ
dti-1314	23	13	cells	cell	NOUN
dti-1314	23	14	are	be	AUX
dti-1314	23	15	able	able	ADJ
dti-1314	23	16	to	to	PART
dti-1314	23	17	survive	survive	VERB
dti-1314	23	18	.	.	PUNCT
dti-1314	24	1	in	in	ADP
dti-1314	24	2	fact	fact	NOUN
dti-1314	24	3	,	,	PUNCT
dti-1314	24	4	exposure	exposure	NOUN
dti-1314	24	5	of	of	ADP
dti-1314	24	6	melanoma	melanoma	NOUN
dti-1314	24	7	cells	cell	NOUN
dti-1314	24	8	to	to	PART
dti-1314	24	9	arginine	arginine	VERB
dti-1314	24	10	deiminase(adi	deiminase(adi	PROPN
dti-1314	24	11	)	)	PUNCT
dti-1314	24	12	,	,	PUNCT
dti-1314	24	13	an	an	DET
dti-1314	24	14	enzyme	enzyme	NOUN
dti-1314	24	15	which	which	PRON
dti-1314	24	16	catalyzes	catalyze	VERB
dti-1314	24	17	the	the	DET
dti-1314	24	18	hydrolysis	hydrolysis	NOUN
dti-1314	24	19	of	of	ADP
dti-1314	24	20	arginine	arginine	NOUN
dti-1314	24	21	to	to	PART
dti-1314	24	22	citrulline	citrulline	NOUN
dti-1314	24	23	results	result	NOUN
dti-1314	24	24	in	in	ADP
dti-1314	24	25	cell	cell	NOUN
dti-1314	24	26	death	death	NOUN
dti-1314	24	27	(	(	PUNCT
dti-1314	24	28	ensor	ensor	PROPN
dti-1314	24	29	et	et	PROPN
dti-1314	24	30	al	al	PROPN
dti-1314	24	31	.	.	PROPN
dti-1314	24	32	2002	2002	NUM
dti-1314	24	33	;	;	PUNCT
dti-1314	24	34	shen	shen	PROPN
dti-1314	24	35	and	and	CCONJ
dti-1314	24	36	shen	shen	PROPN
dti-1314	24	37	,	,	PUNCT
dti-1314	24	38	2006	2006	NUM
dti-1314	24	39	;	;	PUNCT
dti-1314	24	40	sugimura	sugimura	NOUN
dti-1314	24	41	et	et	PROPN
dti-1314	24	42	al	al	PROPN
dti-1314	24	43	.	.	PROPN
dti-1314	24	44	1992	1992	NUM
dti-1314	24	45	;	;	PUNCT
dti-1314	24	46	takaku	takaku	NOUN
dti-1314	24	47	et	et	PROPN
dti-1314	24	48	al	al	PROPN
dti-1314	24	49	.	.	PROPN
dti-1314	24	50	1995	1995	NUM
dti-1314	24	51	;	;	PUNCT
dti-1314	24	52	takaku	takaku	NOUN
dti-1314	24	53	et	et	PROPN
dti-1314	24	54	al	al	PROPN
dti-1314	24	55	.	.	PROPN
dti-1314	24	56	1993	1993	NUM
dti-1314	24	57	)	)	PUNCT
dti-1314	24	58	.	.	PUNCT
dti-1314	25	1	this	this	DET
dti-1314	25	2	laboratory	laboratory	NOUN
dti-1314	25	3	fi	fi	NOUN
dti-1314	25	4	nding	nding	NOUN
dti-1314	25	5	has	have	AUX
dti-1314	25	6	been	be	AUX
dti-1314	25	7	developed	develop	VERB
dti-1314	25	8	into	into	ADP
dti-1314	25	9	clinical	clinical	ADJ
dti-1314	25	10	trial	trial	NOUN
dti-1314	25	11	,	,	PUNCT
dti-1314	25	12	and	and	CCONJ
dti-1314	25	13	antitumor	antitumor	PROPN
dti-1314	25	14	activity	activity	NOUN
dti-1314	25	15	has	have	AUX
dti-1314	25	16	been	be	AUX
dti-1314	25	17	documented	document	VERB
dti-1314	25	18	in	in	ADP
dti-1314	25	19	melanoma	melanoma	NOUN
dti-1314	25	20	patients	patient	NOUN
dti-1314	25	21	(	(	PUNCT
dti-1314	25	22	ascierto	ascierto	PROPN
dti-1314	25	23	et	et	PROPN
dti-1314	25	24	al	al	PROPN
dti-1314	25	25	.	.	PROPN
dti-1314	25	26	2005	2005	NUM
dti-1314	25	27	;	;	PUNCT
dti-1314	25	28	feun	feun	VERB
dti-1314	25	29	and	and	CCONJ
dti-1314	25	30	savaraj	savaraj	ADJ
dti-1314	25	31	,	,	PUNCT
dti-1314	25	32	2006	2006	NUM
dti-1314	25	33	)	)	PUNCT
dti-1314	25	34	.	.	PUNCT
dti-1314	26	1	however	however	ADV
dti-1314	26	2	,	,	PUNCT
dti-1314	26	3	not	not	PART
dti-1314	26	4	all	all	DET
dti-1314	26	5	patients	patient	NOUN
dti-1314	26	6	responded	respond	VERB
dti-1314	26	7	to	to	ADP
dti-1314	26	8	treatment	treatment	NOUN
dti-1314	26	9	and	and	CCONJ
dti-1314	26	10	the	the	DET
dti-1314	26	11	duration	duration	NOUN
dti-1314	26	12	of	of	ADP
dti-1314	26	13	response	response	NOUN
dti-1314	26	14	varied	varied	ADJ
dti-1314	26	15	.	.	PUNCT
dti-1314	27	1	in	in	ADP
dti-1314	27	2	this	this	DET
dti-1314	27	3	communication	communication	NOUN
dti-1314	27	4	we	we	PRON
dti-1314	27	5	explore	explore	VERB
dti-1314	27	6	the	the	DET
dti-1314	27	7	role	role	NOUN
dti-1314	27	8	of	of	ADP
dti-1314	27	9	ass	ass	NOUN
dti-1314	27	10	gene	gene	NOUN
dti-1314	27	11	expression	expression	NOUN
dti-1314	27	12	in	in	ADP
dti-1314	27	13	adi	adi	PROPN
dti-1314	27	14	response	response	NOUN
dti-1314	27	15	/	/	SYM
dti-1314	27	16	resistance	resistance	NOUN
dti-1314	27	17	using	use	VERB
dti-1314	27	18	4	4	NUM
dti-1314	27	19	melanoma	melanoma	NOUN
dti-1314	27	20	cell	cell	NOUN
dti-1314	27	21	lines	line	NOUN
dti-1314	27	22	as	as	ADP
dti-1314	27	23	models	model	NOUN
dti-1314	27	24	.	.	PUNCT
dti-1314	28	1	correspondence	correspondence	NOUN
dti-1314	28	2	:	:	PUNCT
dti-1314	29	1	nirmal	nirmal	PROPN
dti-1314	29	2	savaraj	savaraj	PROPN
dti-1314	29	3	,	,	PUNCT
dti-1314	29	4	va	va	PROPN
dti-1314	29	5	medical	medical	ADJ
dti-1314	29	6	center	center	NOUN
dti-1314	29	7	,	,	PUNCT
dti-1314	29	8	hematology	hematology	NOUN
dti-1314	29	9	-	-	PUNCT
dti-1314	29	10	oncology	oncology	NOUN
dti-1314	29	11	,	,	PUNCT
dti-1314	29	12	1201	1201	NUM
dti-1314	29	13	nw	nw	PROPN
dti-1314	29	14	16th	16th	PROPN
dti-1314	29	15	street	street	PROPN
dti-1314	29	16	,	,	PUNCT
dti-1314	29	17	miami	miami	PROPN
dti-1314	29	18	,	,	PUNCT
dti-1314	29	19	florida	florida	PROPN
dti-1314	29	20	33125	33125	NUM
dti-1314	29	21	.	.	PUNCT
dti-1314	30	1	tel	tel	ADP
dti-1314	30	2	:	:	PUNCT
dti-1314	30	3	305	305	NUM
dti-1314	30	4	-	-	SYM
dti-1314	30	5	575	575	NUM
dti-1314	30	6	-	-	PUNCT
dti-1314	30	7	3143	3143	NUM
dti-1314	30	8	;	;	PUNCT
dti-1314	30	9	email	email	NOUN
dti-1314	30	10	:	:	PUNCT
dti-1314	30	11	nsavaraj@med.miami.edu	nsavaraj@med.miami.edu	NOUN
dti-1314	30	12	please	please	INTJ
dti-1314	30	13	note	note	VERB
dti-1314	30	14	that	that	SCONJ
dti-1314	30	15	this	this	DET
dti-1314	30	16	article	article	NOUN
dti-1314	30	17	may	may	AUX
dti-1314	30	18	not	not	PART
dti-1314	30	19	be	be	AUX
dti-1314	30	20	used	use	VERB
dti-1314	30	21	for	for	ADP
dti-1314	30	22	commercial	commercial	ADJ
dti-1314	30	23	purposes	purpose	NOUN
dti-1314	30	24	.	.	PUNCT
dti-1314	31	1	for	for	ADP
dti-1314	31	2	further	further	ADJ
dti-1314	31	3	information	information	NOUN
dti-1314	31	4	please	please	INTJ
dti-1314	31	5	refer	refer	VERB
dti-1314	31	6	to	to	ADP
dti-1314	31	7	the	the	DET
dti-1314	31	8	copyright	copyright	NOUN
dti-1314	31	9	statement	statement	NOUN
dti-1314	31	10	at	at	ADP
dti-1314	31	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1314	31	12	120	120	NUM
dti-1314	31	13	savaraj	savaraj	VERB
dti-1314	31	14	et	et	PROPN
dti-1314	31	15	al	al	PROPN
dti-1314	31	16	drug	drug	PROPN
dti-1314	31	17	target	target	NOUN
dti-1314	31	18	insights	insight	NOUN
dti-1314	31	19	2007	2007	NUM
dti-1314	31	20	:	:	SYM
dti-1314	31	21	2	2	NUM
dti-1314	31	22	material	material	NOUN
dti-1314	31	23	and	and	CCONJ
dti-1314	31	24	methods	method	NOUN
dti-1314	31	25	cell	cell	NOUN
dti-1314	31	26	lines	line	NOUN
dti-1314	31	27	four	four	NUM
dti-1314	31	28	human	human	ADJ
dti-1314	31	29	melanoma	melanoma	NOUN
dti-1314	31	30	cell	cell	NOUN
dti-1314	31	31	lines	line	NOUN
dti-1314	31	32	were	be	AUX
dti-1314	31	33	used	use	VERB
dti-1314	31	34	:	:	PUNCT
dti-1314	31	35	a375	a375	PROPN
dti-1314	31	36	,	,	PUNCT
dti-1314	31	37	sk	sk	NOUN
dti-1314	31	38	-	-	PUNCT
dti-1314	31	39	mel-2	mel-2	NOUN
dti-1314	31	40	,	,	PUNCT
dti-1314	31	41	a2058	a2058	NUM
dti-1314	31	42	and	and	CCONJ
dti-1314	31	43	mel-1220	mel-1220	NOUN
dti-1314	31	44	.	.	PUNCT
dti-1314	32	1	the	the	DET
dti-1314	32	2	fi	fi	NOUN
dti-1314	32	3	rst	rst	PROPN
dti-1314	32	4	three	three	NUM
dti-1314	32	5	cell	cell	NOUN
dti-1314	32	6	lines	line	NOUN
dti-1314	32	7	(	(	PUNCT
dti-1314	32	8	a375	a375	PROPN
dti-1314	32	9	,	,	PUNCT
dti-1314	32	10	sk	sk	NOUN
dti-1314	32	11	-	-	PUNCT
dti-1314	32	12	mel-2	mel-2	NUM
dti-1314	32	13	and	and	CCONJ
dti-1314	32	14	a2058	a2058	NUM
dti-1314	32	15	)	)	PUNCT
dti-1314	32	16	were	be	AUX
dti-1314	32	17	from	from	ADP
dti-1314	32	18	atcc	atcc	NOUN
dti-1314	32	19	,	,	PUNCT
dti-1314	32	20	and	and	CCONJ
dti-1314	32	21	mel-1220	mel-1220	NOUN
dti-1314	32	22	was	be	AUX
dti-1314	32	23	established	establish	VERB
dti-1314	32	24	in	in	ADP
dti-1314	32	25	our	our	PRON
dti-1314	32	26	laboratory	laboratory	NOUN
dti-1314	32	27	from	from	ADP
dti-1314	32	28	a	a	DET
dti-1314	32	29	subcutaneous	subcutaneous	ADJ
dti-1314	32	30	biopsy	biopsy	NOUN
dti-1314	32	31	of	of	ADP
dti-1314	32	32	a	a	DET
dti-1314	32	33	melanoma	melanoma	NOUN
dti-1314	32	34	patient	patient	NOUN
dti-1314	32	35	.	.	PUNCT
dti-1314	33	1	this	this	DET
dti-1314	33	2	cell	cell	NOUN
dti-1314	33	3	line	line	NOUN
dti-1314	33	4	produces	produce	VERB
dti-1314	33	5	melanin	melanin	NOUN
dti-1314	33	6	pigment	pigment	NOUN
dti-1314	33	7	and	and	CCONJ
dti-1314	33	8	is	be	AUX
dti-1314	33	9	positive	positive	ADJ
dti-1314	33	10	for	for	ADP
dti-1314	33	11	s-100	s-100	NUM
dti-1314	33	12	.	.	PUNCT
dti-1314	34	1	a	a	DET
dti-1314	34	2	telomerase	telomerase	NOUN
dti-1314	34	3	immortalized	immortalize	VERB
dti-1314	34	4	normal	normal	ADJ
dti-1314	34	5	foreskin	foreskin	ADJ
dti-1314	34	6	fi	fi	NOUN
dti-1314	34	7	broblast	broblast	ADJ
dti-1314	34	8	cell	cell	NOUN
dti-1314	34	9	line	line	NOUN
dti-1314	34	10	(	(	PUNCT
dti-1314	34	11	bj-1	bj-1	ADV
dti-1314	34	12	)	)	PUNCT
dti-1314	34	13	was	be	AUX
dti-1314	34	14	purchased	purchase	VERB
dti-1314	34	15	from	from	ADP
dti-1314	34	16	clonetech	clonetech	NOUN
dti-1314	34	17	to	to	PART
dti-1314	34	18	be	be	AUX
dti-1314	34	19	used	use	VERB
dti-1314	34	20	as	as	ADP
dti-1314	34	21	normal	normal	ADJ
dti-1314	34	22	control	control	NOUN
dti-1314	34	23	.	.	PUNCT
dti-1314	35	1	nsclcs	nsclcs	NOUN
dti-1314	35	2	was	be	AUX
dti-1314	35	3	derived	derive	VERB
dti-1314	35	4	from	from	ADP
dti-1314	35	5	metastatic	metastatic	ADJ
dti-1314	35	6	adenocarcinoma	adenocarcinoma	NOUN
dti-1314	35	7	to	to	ADP
dti-1314	35	8	the	the	DET
dti-1314	35	9	brain	brain	NOUN
dti-1314	35	10	from	from	ADP
dti-1314	35	11	primary	primary	ADJ
dti-1314	35	12	lung	lung	NOUN
dti-1314	35	13	cancer	cancer	NOUN
dti-1314	35	14	.	.	PUNCT
dti-1314	36	1	this	this	DET
dti-1314	36	2	cell	cell	NOUN
dti-1314	36	3	line	line	NOUN
dti-1314	36	4	grows	grow	VERB
dti-1314	36	5	in	in	ADP
dti-1314	36	6	monlayer	monlayer	NOUN
dti-1314	36	7	and	and	CCONJ
dti-1314	36	8	was	be	AUX
dti-1314	36	9	positive	positive	ADJ
dti-1314	36	10	for	for	ADP
dti-1314	36	11	keratin	keratin	NOUN
dti-1314	36	12	and	and	CCONJ
dti-1314	36	13	epithelial	epithelial	ADJ
dti-1314	36	14	membrane	membrane	NOUN
dti-1314	36	15	antigen	antigen	ADV
dti-1314	36	16	.	.	PUNCT
dti-1314	37	1	all	all	DET
dti-1314	37	2	cells	cell	NOUN
dti-1314	37	3	were	be	AUX
dti-1314	37	4	cultured	cultured	ADJ
dti-1314	37	5	in	in	ADP
dti-1314	37	6	mem	mem	ADJ
dti-1314	37	7	with	with	ADP
dti-1314	37	8	10	10	NUM
dti-1314	37	9	%	%	NOUN
dti-1314	37	10	fcs	fcs	NOUN
dti-1314	37	11	and	and	CCONJ
dti-1314	37	12	penicillin	penicillin	PROPN
dti-1314	37	13	/	/	SYM
dti-1314	37	14	streptomycin	streptomycin	PROPN
dti-1314	37	15	.	.	PUNCT
dti-1314	38	1	cells	cell	NOUN
dti-1314	38	2	were	be	AUX
dti-1314	38	3	checked	check	VERB
dti-1314	38	4	for	for	ADP
dti-1314	38	5	mycoplasma	mycoplasma	NOUN
dti-1314	38	6	every	every	DET
dti-1314	38	7	month	month	NOUN
dti-1314	38	8	using	use	VERB
dti-1314	38	9	mycoalert	mycoalert	NOUN
dti-1314	38	10	mycoplasma	mycoplasma	NOUN
dti-1314	38	11	detection	detection	NOUN
dti-1314	38	12	kit	kit	NOUN
dti-1314	38	13	purchased	purchase	VERB
dti-1314	38	14	from	from	ADP
dti-1314	38	15	cambrex	cambrex	PROPN
dti-1314	38	16	.	.	PUNCT
dti-1314	39	1	reagent	reagent	ADJ
dti-1314	39	2	adi	adi	PROPN
dti-1314	39	3	-	-	PUNCT
dti-1314	39	4	peg20	peg20	PROPN
dti-1314	39	5	was	be	AUX
dti-1314	39	6	supplied	supply	VERB
dti-1314	39	7	by	by	ADP
dti-1314	39	8	polaris	polaris	PROPN
dti-1314	39	9	inc	inc	PROPN
dti-1314	39	10	.	.	PROPN
dti-1314	39	11	larg	larg	NOUN
dti-1314	39	12	-	-	PUNCT
dti-1314	39	13	free	free	ADJ
dti-1314	39	14	medium	medium	NOUN
dti-1314	39	15	was	be	AUX
dti-1314	39	16	purchased	purchase	VERB
dti-1314	39	17	from	from	ADP
dti-1314	39	18	invitrogen	invitrogen	PROPN
dti-1314	39	19	.	.	PUNCT
dti-1314	40	1	ass	ass	NOUN
dti-1314	40	2	antibody	antibody	NOUN
dti-1314	40	3	was	be	AUX
dti-1314	40	4	purchased	purchase	VERB
dti-1314	40	5	from	from	ADP
dti-1314	40	6	bd	bd	PROPN
dti-1314	40	7	bioscience	bioscience	PROPN
dti-1314	40	8	.	.	PUNCT
dti-1314	41	1	ass	ass	NOUN
dti-1314	41	2	antibody	antibody	NOUN
dti-1314	41	3	was	be	AUX
dti-1314	41	4	purchased	purchase	VERB
dti-1314	41	5	from	from	ADP
dti-1314	41	6	bd	bd	PROPN
dti-1314	41	7	-	-	NOUN
dti-1314	41	8	biosciences	bioscience	NOUN
dti-1314	41	9	.	.	PUNCT
dti-1314	42	1	parp	parp	ADJ
dti-1314	42	2	antibody	antibody	NOUN
dti-1314	42	3	was	be	AUX
dti-1314	42	4	purchased	purchase	VERB
dti-1314	42	5	from	from	ADP
dti-1314	42	6	cell	cell	NOUN
dti-1314	42	7	signaling	signal	VERB
dti-1314	42	8	and	and	CCONJ
dti-1314	42	9	actin	actin	NOUN
dti-1314	42	10	antibody	antibody	NOUN
dti-1314	42	11	was	be	AUX
dti-1314	42	12	purchased	purchase	VERB
dti-1314	42	13	from	from	ADP
dti-1314	42	14	sigma	sigma	PROPN
dti-1314	42	15	.	.	PUNCT
dti-1314	43	1	growth	growth	NOUN
dti-1314	43	2	inhibitory	inhibitory	ADJ
dti-1314	43	3	effect	effect	NOUN
dti-1314	43	4	0.6	0.6	NUM
dti-1314	43	5	×	×	NOUN
dti-1314	43	6	105	105	NUM
dti-1314	43	7	cells	cell	NOUN
dti-1314	43	8	were	be	AUX
dti-1314	43	9	seeded	seed	VERB
dti-1314	43	10	onto	onto	ADP
dti-1314	43	11	24	24	NUM
dti-1314	43	12	-	-	PUNCT
dti-1314	43	13	well	well	NOUN
dti-1314	43	14	plates	plate	NOUN
dti-1314	43	15	and	and	CCONJ
dti-1314	43	16	allowed	allow	VERB
dti-1314	43	17	6	6	NUM
dti-1314	43	18	hr	hr	NOUN
dti-1314	43	19	.	.	PUNCT
dti-1314	44	1	for	for	ADP
dti-1314	44	2	attachment	attachment	NOUN
dti-1314	44	3	.	.	PUNCT
dti-1314	45	1	various	various	ADJ
dti-1314	45	2	concentrations	concentration	NOUN
dti-1314	45	3	of	of	ADP
dti-1314	45	4	adi	adi	PROPN
dti-1314	45	5	were	be	AUX
dti-1314	45	6	added	add	VERB
dti-1314	45	7	to	to	ADP
dti-1314	45	8	each	each	DET
dti-1314	45	9	well	well	ADV
dti-1314	45	10	.	.	PUNCT
dti-1314	46	1	each	each	DET
dti-1314	46	2	concentration	concentration	NOUN
dti-1314	46	3	was	be	AUX
dti-1314	46	4	performed	perform	VERB
dti-1314	46	5	in	in	ADP
dti-1314	46	6	duplicate	duplicate	NOUN
dti-1314	46	7	.	.	PUNCT
dti-1314	47	1	after	after	ADP
dti-1314	47	2	72	72	NUM
dti-1314	47	3	hr	hr	NOUN
dti-1314	47	4	.	.	PUNCT
dti-1314	47	5	exposure	exposure	NOUN
dti-1314	47	6	,	,	PUNCT
dti-1314	47	7	cells	cell	NOUN
dti-1314	47	8	were	be	AUX
dti-1314	47	9	counted	count	VERB
dti-1314	47	10	in	in	ADP
dti-1314	47	11	the	the	DET
dti-1314	47	12	presence	presence	NOUN
dti-1314	47	13	of	of	ADP
dti-1314	47	14	0.2	0.2	NUM
dti-1314	47	15	%	%	NOUN
dti-1314	47	16	trypan	trypan	NOUN
dti-1314	47	17	blue	blue	NOUN
dti-1314	47	18	.	.	PUNCT
dti-1314	48	1	the	the	DET
dti-1314	48	2	growth	growth	NOUN
dti-1314	48	3	inhibitory	inhibitory	ADJ
dti-1314	48	4	effect	effect	NOUN
dti-1314	48	5	(	(	PUNCT
dti-1314	48	6	id50	id50	PROPN
dti-1314	48	7	)	)	PUNCT
dti-1314	48	8	was	be	AUX
dti-1314	48	9	determined	determine	VERB
dti-1314	48	10	by	by	ADP
dti-1314	48	11	plotting	plot	VERB
dti-1314	48	12	the	the	DET
dti-1314	48	13	number	number	NOUN
dti-1314	48	14	of	of	ADP
dti-1314	48	15	viable	viable	ADJ
dti-1314	48	16	cells	cell	NOUN
dti-1314	48	17	as	as	ADP
dti-1314	48	18	a	a	DET
dti-1314	48	19	percentage	percentage	NOUN
dti-1314	48	20	of	of	ADP
dti-1314	48	21	control	control	NOUN
dti-1314	48	22	against	against	ADP
dti-1314	48	23	the	the	DET
dti-1314	48	24	compound	compound	NOUN
dti-1314	48	25	concentration	concentration	NOUN
dti-1314	48	26	.	.	PUNCT
dti-1314	49	1	detection	detection	NOUN
dti-1314	49	2	of	of	ADP
dti-1314	49	3	apoptosis	apoptosis	NOUN
dti-1314	49	4	cells	cell	NOUN
dti-1314	49	5	(	(	PUNCT
dti-1314	49	6	1	1	NUM
dti-1314	49	7	×	×	NOUN
dti-1314	49	8	104	104	NUM
dti-1314	49	9	)	)	PUNCT
dti-1314	49	10	were	be	AUX
dti-1314	49	11	seeded	seed	VERB
dti-1314	49	12	onto	onto	ADP
dti-1314	49	13	lab	lab	NOUN
dti-1314	49	14	-	-	PUNCT
dti-1314	49	15	tek	tek	PROPN
dti-1314	49	16	chamber	chamber	NOUN
dti-1314	49	17	slides	slide	NOUN
dti-1314	49	18	(	(	PUNCT
dti-1314	49	19	nalge	nalge	PROPN
dti-1314	49	20	nunc	nunc	PROPN
dti-1314	49	21	international	international	PROPN
dti-1314	49	22	)	)	PUNCT
dti-1314	49	23	and	and	CCONJ
dti-1314	49	24	then	then	ADV
dti-1314	49	25	exposed	expose	VERB
dti-1314	49	26	to	to	ADP
dti-1314	49	27	adi	adi	NOUN
dti-1314	49	28	-	-	PUNCT
dti-1314	49	29	peg20	peg20	NOUN
dti-1314	49	30	at	at	ADP
dti-1314	49	31	0.1	0.1	NUM
dti-1314	49	32	ug	ug	ADP
dti-1314	49	33	/	/	SYM
dti-1314	49	34	ml	ml	NOUN
dti-1314	49	35	for	for	ADP
dti-1314	49	36	72	72	NUM
dti-1314	49	37	hrs	hrs	NOUN
dti-1314	49	38	.	.	PUNCT
dti-1314	50	1	the	the	DET
dti-1314	50	2	apoptotic	apoptotic	ADJ
dti-1314	50	3	cells	cell	NOUN
dti-1314	50	4	were	be	AUX
dti-1314	50	5	detected	detect	VERB
dti-1314	50	6	by	by	ADP
dti-1314	50	7	an	an	DET
dti-1314	50	8	in	in	ADP
dti-1314	50	9	situ	situ	ADJ
dti-1314	50	10	endlabeling	endlabeling	NOUN
dti-1314	50	11	assay	assay	NOUN
dti-1314	50	12	using	use	VERB
dti-1314	50	13	a	a	DET
dti-1314	50	14	kit	kit	NOUN
dti-1314	50	15	from	from	ADP
dti-1314	50	16	oncor	oncor	PROPN
dti-1314	50	17	.	.	PUNCT
dti-1314	51	1	briefl	briefl	PROPN
dti-1314	51	2	y	y	PROPN
dti-1314	51	3	,	,	PUNCT
dti-1314	51	4	cells	cell	NOUN
dti-1314	51	5	were	be	AUX
dti-1314	51	6	fi	fi	NOUN
dti-1314	51	7	xed	xe	VERB
dti-1314	51	8	in	in	ADP
dti-1314	51	9	4	4	NUM
dti-1314	51	10	%	%	NOUN
dti-1314	51	11	neutral	neutral	ADJ
dti-1314	51	12	buffered	buffer	VERB
dti-1314	51	13	formalin	formalin	NOUN
dti-1314	51	14	,	,	PUNCT
dti-1314	51	15	treated	treat	VERB
dti-1314	51	16	with	with	ADP
dti-1314	51	17	2	2	NUM
dti-1314	51	18	%	%	NOUN
dti-1314	51	19	hydrogen	hydrogen	NOUN
dti-1314	51	20	peroxide	peroxide	NOUN
dti-1314	51	21	,	,	PUNCT
dti-1314	51	22	and	and	CCONJ
dti-1314	51	23	incubated	incubate	VERB
dti-1314	51	24	with	with	ADP
dti-1314	51	25	terminal	terminal	ADJ
dti-1314	51	26	deoxynucleotide	deoxynucleotide	NOUN
dti-1314	51	27	transferase	transferase	NOUN
dti-1314	51	28	enzyme	enzyme	NOUN
dti-1314	51	29	and	and	CCONJ
dti-1314	51	30	digoxigenin-11	digoxigenin-11	NOUN
dti-1314	51	31	-	-	NOUN
dti-1314	51	32	dutp	dutp	NOUN
dti-1314	51	33	under	under	ADP
dti-1314	51	34	a	a	DET
dti-1314	51	35	plastic	plastic	NOUN
dti-1314	51	36	coverslip	coverslip	NOUN
dti-1314	51	37	for	for	ADP
dti-1314	51	38	1	1	NUM
dti-1314	51	39	hr	hr	NOUN
dti-1314	51	40	.	.	PUNCT
dti-1314	52	1	anti	anti	ADJ
dti-1314	52	2	-	-	ADJ
dti-1314	52	3	digoxigenin	digoxigenin	ADJ
dti-1314	52	4	peroxidase	peroxidase	NOUN
dti-1314	52	5	was	be	AUX
dti-1314	52	6	applied	apply	VERB
dti-1314	52	7	to	to	ADP
dti-1314	52	8	the	the	DET
dti-1314	52	9	slide	slide	NOUN
dti-1314	52	10	,	,	PUNCT
dti-1314	52	11	followed	follow	VERB
dti-1314	52	12	by	by	ADP
dti-1314	52	13	the	the	DET
dti-1314	52	14	chromogenic	chromogenic	ADJ
dti-1314	52	15	substrate	substrate	NOUN
dti-1314	52	16	diaminobenzidine	diaminobenzidine	NOUN
dti-1314	52	17	and	and	CCONJ
dti-1314	52	18	counterstained	counterstaine	VERB
dti-1314	52	19	with	with	ADP
dti-1314	52	20	hematoxylin	hematoxylin	PROPN
dti-1314	52	21	.	.	PUNCT
dti-1314	53	1	cells	cell	NOUN
dti-1314	53	2	that	that	PRON
dti-1314	53	3	underwent	underwent	ADJ
dti-1314	53	4	apoptosis	apoptosis	NOUN
dti-1314	53	5	showed	show	VERB
dti-1314	53	6	dark	dark	ADJ
dti-1314	53	7	brown	brown	ADJ
dti-1314	53	8	staining	stain	VERB
dti-1314	53	9	in	in	ADP
dti-1314	53	10	the	the	DET
dti-1314	53	11	nuclei	nucleus	NOUN
dti-1314	53	12	.	.	PUNCT
dti-1314	54	1	we	we	PRON
dti-1314	54	2	have	have	AUX
dti-1314	54	3	also	also	ADV
dti-1314	54	4	used	use	VERB
dti-1314	54	5	poly	poly	ADJ
dti-1314	54	6	adp	adp	PROPN
dti-1314	54	7	-	-	PUNCT
dti-1314	54	8	ribose	ribose	ADJ
dti-1314	54	9	polymerase	polymerase	NOUN
dti-1314	54	10	cleavage	cleavage	NOUN
dti-1314	54	11	assay	assay	VERB
dti-1314	54	12	to	to	PART
dti-1314	54	13	detect	detect	VERB
dti-1314	54	14	apoptosis	apoptosis	NOUN
dti-1314	54	15	.	.	PUNCT
dti-1314	55	1	during	during	ADP
dti-1314	55	2	apoptosis	apoptosis	NOUN
dti-1314	55	3	ice	ice	NOUN
dti-1314	55	4	family	family	NOUN
dti-1314	55	5	such	such	ADJ
dti-1314	55	6	as	as	ADP
dti-1314	55	7	caspase-3	caspase-3	NUM
dti-1314	55	8	and	and	CCONJ
dti-1314	55	9	caspase-7	caspase-7	NUM
dti-1314	55	10	cleave	cleave	NOUN
dti-1314	55	11	parp	parp	NOUN
dti-1314	55	12	to	to	PART
dti-1314	55	13	yield	yield	VERB
dti-1314	55	14	85	85	NUM
dti-1314	55	15	and	and	CCONJ
dti-1314	55	16	25	25	NUM
dti-1314	55	17	kda	kda	NOUN
dti-1314	55	18	fragments	fragment	NOUN
dti-1314	55	19	.	.	PUNCT
dti-1314	56	1	briefl	briefl	PROPN
dti-1314	56	2	y	y	PROPN
dti-1314	56	3	,	,	PUNCT
dti-1314	56	4	cells	cell	NOUN
dti-1314	56	5	were	be	AUX
dti-1314	56	6	treated	treat	VERB
dti-1314	56	7	with	with	ADP
dti-1314	56	8	adi	adi	NOUN
dti-1314	56	9	-	-	PUNCT
dti-1314	56	10	peg20	peg20	PROPN
dti-1314	56	11	for	for	ADP
dti-1314	56	12	72	72	NUM
dti-1314	56	13	hrs	hrs	NOUN
dti-1314	56	14	,	,	PUNCT
dti-1314	56	15	nuclear	nuclear	ADJ
dti-1314	56	16	protein	protein	NOUN
dti-1314	56	17	was	be	AUX
dti-1314	56	18	obtained	obtain	VERB
dti-1314	56	19	and	and	CCONJ
dti-1314	56	20	immunoblot	immunoblot	NOUN
dti-1314	56	21	was	be	AUX
dti-1314	56	22	performed	perform	VERB
dti-1314	56	23	using	use	VERB
dti-1314	56	24	parp	parp	ADJ
dti-1314	56	25	rabbit	rabbit	NOUN
dti-1314	56	26	polyclonal	polyclonal	ADJ
dti-1314	56	27	antibody	antibody	NOUN
dti-1314	56	28	purchased	purchase	VERB
dti-1314	56	29	from	from	ADP
dti-1314	56	30	cell	cell	NOUN
dti-1314	56	31	signaling	signal	VERB
dti-1314	56	32	.	.	PUNCT
dti-1314	57	1	analysis	analysis	NOUN
dti-1314	57	2	of	of	ADP
dti-1314	57	3	arginine	arginine	NOUN
dti-1314	57	4	and	and	CCONJ
dti-1314	57	5	citrulline	citrulline	NOUN
dti-1314	57	6	by	by	ADP
dti-1314	57	7	hplc	hplc	NOUN
dti-1314	57	8	arginine	arginine	NOUN
dti-1314	57	9	and	and	CCONJ
dti-1314	57	10	citrulline	citrulline	NOUN
dti-1314	57	11	analysis	analysis	NOUN
dti-1314	57	12	was	be	AUX
dti-1314	57	13	performed	perform	VERB
dti-1314	57	14	by	by	ADP
dti-1314	57	15	cation	cation	NOUN
dti-1314	57	16	exchange	exchange	NOUN
dti-1314	57	17	hewlett	hewlett	PROPN
dti-1314	57	18	packard	packard	PROPN
dti-1314	57	19	1100	1100	NUM
dti-1314	57	20	series	series	PROPN
dti-1314	57	21	hplc	hplc	PROPN
dti-1314	57	22	with	with	ADP
dti-1314	57	23	a	a	DET
dti-1314	57	24	post	post	ADJ
dti-1314	57	25	-	-	ADJ
dti-1314	57	26	column	column	NOUN
dti-1314	57	27	derivitization(11	derivitization(11	NOUN
dti-1314	57	28	)	)	PUNCT
dti-1314	57	29	.	.	PUNCT
dti-1314	58	1	this	this	DET
dti-1314	58	2	instrument	instrument	NOUN
dti-1314	58	3	utilizes	utilize	VERB
dti-1314	58	4	a	a	DET
dti-1314	58	5	cation	cation	NOUN
dti-1314	58	6	exchange	exchange	NOUN
dti-1314	58	7	column	column	NOUN
dti-1314	58	8	and	and	CCONJ
dti-1314	58	9	a	a	DET
dti-1314	58	10	guard	guard	NOUN
dti-1314	58	11	column	column	NOUN
dti-1314	58	12	.	.	PUNCT
dti-1314	59	1	the	the	DET
dti-1314	59	2	temperature	temperature	NOUN
dti-1314	59	3	was	be	AUX
dti-1314	59	4	set	set	VERB
dti-1314	59	5	at	at	ADP
dti-1314	59	6	34	34	NUM
dti-1314	59	7	°	°	NOUN
dti-1314	59	8	c	c	NOUN
dti-1314	59	9	and	and	CCONJ
dti-1314	59	10	the	the	DET
dti-1314	59	11	reactor	reactor	NOUN
dti-1314	59	12	temperature	temperature	NOUN
dti-1314	59	13	was	be	AUX
dti-1314	59	14	set	set	VERB
dti-1314	59	15	at	at	ADP
dti-1314	59	16	39	39	NUM
dti-1314	59	17	°	°	NOUN
dti-1314	59	18	c	c	NOUN
dti-1314	59	19	.	.	PUNCT
dti-1314	60	1	amino	amino	NOUN
dti-1314	60	2	acid	acid	NOUN
dti-1314	60	3	standards	standard	NOUN
dti-1314	60	4	arginine	arginine	NOUN
dti-1314	60	5	and	and	CCONJ
dti-1314	60	6	citrulline	citrulline	NOUN
dti-1314	60	7	were	be	AUX
dti-1314	60	8	prepared	prepare	VERB
dti-1314	60	9	in	in	ADP
dti-1314	60	10	li220	li220	ADJ
dti-1314	60	11	diluent	diluent	NOUN
dti-1314	60	12	(	(	PUNCT
dti-1314	60	13	all	all	DET
dti-1314	60	14	mobile	mobile	ADJ
dti-1314	60	15	phase	phase	NOUN
dti-1314	60	16	reagents	reagent	NOUN
dti-1314	60	17	were	be	AUX
dti-1314	60	18	obtained	obtain	VERB
dti-1314	60	19	as	as	ADP
dti-1314	60	20	pre	pre	ADJ
dti-1314	60	21	-	-	ADJ
dti-1314	60	22	mixed	mixed	ADJ
dti-1314	60	23	preparations	preparation	NOUN
dti-1314	60	24	from	from	ADP
dti-1314	60	25	pickering	pickere	VERB
dti-1314	60	26	laboratories	laboratory	NOUN
dti-1314	60	27	)	)	PUNCT
dti-1314	60	28	.	.	PUNCT
dti-1314	61	1	the	the	DET
dti-1314	61	2	mobile	mobile	ADJ
dti-1314	61	3	phase	phase	NOUN
dti-1314	61	4	reagents	reagent	NOUN
dti-1314	61	5	were	be	AUX
dti-1314	61	6	pump	pump	VERB
dti-1314	61	7	a	a	DET
dti-1314	61	8	li280	li280	PROPN
dti-1314	61	9	,	,	PUNCT
dti-1314	61	10	pump	pump	VERB
dti-1314	61	11	b	b	PROPN
dti-1314	61	12	li750	li750	PROPN
dti-1314	61	13	,	,	PUNCT
dti-1314	61	14	pump	pump	NOUN
dti-1314	61	15	c	c	PROPN
dti-1314	61	16	rg003	rg003	PROPN
dti-1314	61	17	.	.	PUNCT
dti-1314	62	1	the	the	DET
dti-1314	62	2	initial	initial	ADJ
dti-1314	62	3	conditions	condition	NOUN
dti-1314	62	4	were	be	AUX
dti-1314	62	5	100	100	NUM
dti-1314	62	6	%	%	NOUN
dti-1314	62	7	a	a	PRON
dti-1314	62	8	for	for	ADP
dti-1314	62	9	12	12	NUM
dti-1314	62	10	min	min	NOUN
dti-1314	62	11	.	.	PROPN
dti-1314	62	12	,	,	PUNCT
dti-1314	62	13	followed	follow	VERB
dti-1314	62	14	by	by	ADP
dti-1314	62	15	a	a	DET
dti-1314	62	16	linear	linear	ADJ
dti-1314	62	17	gradient	gradient	NOUN
dti-1314	62	18	of	of	ADP
dti-1314	62	19	015	015	NUM
dti-1314	62	20	%	%	NOUN
dti-1314	62	21	b	b	NOUN
dti-1314	62	22	over	over	ADP
dti-1314	62	23	the	the	DET
dti-1314	62	24	next	next	ADJ
dti-1314	62	25	16	16	NUM
dti-1314	62	26	min	min	NOUN
dti-1314	62	27	.	.	PUNCT
dti-1314	63	1	the	the	DET
dti-1314	63	2	mobile	mobile	ADJ
dti-1314	63	3	phase	phase	NOUN
dti-1314	63	4	was	be	AUX
dti-1314	63	5	then	then	ADV
dti-1314	63	6	switched	switch	VERB
dti-1314	63	7	to	to	ADP
dti-1314	63	8	92	92	NUM
dti-1314	63	9	%	%	NOUN
dti-1314	63	10	b	b	NOUN
dti-1314	63	11	and	and	CCONJ
dti-1314	63	12	8	8	NUM
dti-1314	63	13	%	%	NOUN
dti-1314	63	14	c	c	NOUN
dti-1314	63	15	and	and	CCONJ
dti-1314	63	16	an	an	DET
dti-1314	63	17	isocratic	isocratic	ADJ
dti-1314	63	18	gradient	gradient	NOUN
dti-1314	63	19	was	be	AUX
dti-1314	63	20	run	run	VERB
dti-1314	63	21	for	for	ADP
dti-1314	63	22	an	an	DET
dti-1314	63	23	additional	additional	ADJ
dti-1314	63	24	37	37	NUM
dti-1314	63	25	min	min	NOUN
dti-1314	63	26	.	.	PUNCT
dti-1314	64	1	a	a	DET
dti-1314	64	2	constant	constant	ADJ
dti-1314	64	3	fl	fl	NOUN
dti-1314	64	4	ow	ow	INTJ
dti-1314	64	5	rate	rate	NOUN
dti-1314	64	6	of	of	ADP
dti-1314	64	7	0.3	0.3	NUM
dti-1314	64	8	ml	ml	NOUN
dti-1314	64	9	/	/	SYM
dti-1314	64	10	minute	minute	NOUN
dti-1314	64	11	was	be	AUX
dti-1314	64	12	used	use	VERB
dti-1314	64	13	.	.	PUNCT
dti-1314	65	1	ass	ass	NOUN
dti-1314	65	2	expression	expression	NOUN
dti-1314	65	3	detected	detect	VERB
dti-1314	65	4	by	by	ADP
dti-1314	65	5	reverse	reverse	ADJ
dti-1314	65	6	transcriptase	transcriptase	NOUN
dti-1314	65	7	polymerase	polymerase	NOUN
dti-1314	65	8	chain	chain	NOUN
dti-1314	65	9	reaction	reaction	NOUN
dti-1314	65	10	total	total	NOUN
dti-1314	65	11	rna	rna	PROPN
dti-1314	65	12	was	be	AUX
dti-1314	65	13	extracted	extract	VERB
dti-1314	65	14	using	use	VERB
dti-1314	65	15	the	the	DET
dti-1314	65	16	kit	kit	NOUN
dti-1314	65	17	from	from	ADP
dti-1314	65	18	invitrogen	invitrogen	PROPN
dti-1314	65	19	.	.	PUNCT
dti-1314	66	1	first	first	ADJ
dti-1314	66	2	-	-	PUNCT
dti-1314	66	3	strand	strand	NOUN
dti-1314	66	4	cdna	cdna	PROPN
dti-1314	66	5	was	be	AUX
dti-1314	66	6	generated	generate	VERB
dti-1314	66	7	from	from	ADP
dti-1314	66	8	0.2ug	0.2ug	PROPN
dti-1314	66	9	of	of	ADP
dti-1314	66	10	total	total	ADJ
dti-1314	66	11	rna	rna	NOUN
dti-1314	66	12	using	use	VERB
dti-1314	66	13	mlv	mlv	ADJ
dti-1314	66	14	reverse	reverse	NOUN
dti-1314	66	15	-	-	PUNCT
dti-1314	66	16	transcription	transcription	NOUN
dti-1314	66	17	.	.	PUNCT
dti-1314	67	1	the	the	DET
dti-1314	67	2	amplifi	amplifi	NOUN
dti-1314	67	3	cation	cation	NOUN
dti-1314	67	4	was	be	AUX
dti-1314	67	5	carried	carry	VERB
dti-1314	67	6	out	out	ADP
dti-1314	67	7	using	use	VERB
dti-1314	67	8	the	the	DET
dti-1314	67	9	following	follow	VERB
dti-1314	67	10	primers	primer	NOUN
dti-1314	67	11	:	:	PUNCT
dti-1314	67	12	forward	forward	NOUN
dti-1314	67	13	primer	primer	NOUN
dti-1314	67	14	:	:	PUNCT
dti-1314	67	15	ggccaaaaaggtgttcattg	ggccaaaaaggtgttcattg	NOUN
dti-1314	67	16	(	(	PUNCT
dti-1314	67	17	nt	not	PART
dti-1314	67	18	:	:	PUNCT
dti-1314	67	19	240–259	240–259	NUM
dti-1314	67	20	)	)	PUNCT
dti-1314	67	21	;	;	PUNCT
dti-1314	67	22	reverse	reverse	NOUN
dti-1314	67	23	primer	primer	NOUN
dti-1314	67	24	:	:	PUNCT
dti-1314	67	25	attccaatgaagcggttctc	attccaatgaagcggttctc	NOUN
dti-1314	67	26	(	(	PUNCT
dti-1314	67	27	nt	not	PART
dti-1314	67	28	:	:	PUNCT
dti-1314	67	29	883–902	883–902	NUM
dti-1314	67	30	)	)	PUNCT
dti-1314	67	31	and	and	CCONJ
dti-1314	67	32	set	set	VERB
dti-1314	67	33	as	as	SCONJ
dti-1314	67	34	follows	follow	VERB
dti-1314	67	35	:	:	PUNCT
dti-1314	67	36	denature	denature	NOUN
dti-1314	67	37	:	:	PUNCT
dti-1314	67	38	45	45	NUM
dti-1314	67	39	sec	sec	PROPN
dti-1314	67	40	.	.	PUNCT
dti-1314	68	1	at	at	ADP
dti-1314	68	2	94	94	NUM
dti-1314	68	3	°	°	NOUN
dti-1314	68	4	c	c	NOUN
dti-1314	68	5	,	,	PUNCT
dti-1314	68	6	annealing	anneal	VERB
dti-1314	68	7	45	45	NUM
dti-1314	68	8	second	second	NOUN
dti-1314	68	9	at	at	ADP
dti-1314	68	10	60	60	NUM
dti-1314	68	11	°	°	ADP
dti-1314	68	12	c	c	NOUN
dti-1314	68	13	and	and	CCONJ
dti-1314	68	14	extension	extension	NOUN
dti-1314	68	15	1	1	NUM
dti-1314	68	16	min	min	NOUN
dti-1314	68	17	.	.	PROPN
dti-1314	68	18	at	at	ADP
dti-1314	68	19	72	72	NUM
dti-1314	68	20	°	°	ADP
dti-1314	68	21	c	c	NOUN
dti-1314	68	22	for	for	ADP
dti-1314	68	23	a	a	DET
dti-1314	68	24	total	total	NOUN
dti-1314	68	25	of	of	ADP
dti-1314	68	26	30	30	NUM
dti-1314	68	27	cycles	cycle	NOUN
dti-1314	68	28	.	.	PUNCT
dti-1314	69	1	gapdh	gapdh	NOUN
dti-1314	69	2	was	be	AUX
dti-1314	69	3	used	use	VERB
dti-1314	69	4	as	as	ADP
dti-1314	69	5	control	control	NOUN
dti-1314	69	6	.	.	PUNCT
dti-1314	70	1	the	the	DET
dti-1314	70	2	primers	primer	NOUN
dti-1314	70	3	for	for	ADP
dti-1314	70	4	gapdh	gapdh	NOUN
dti-1314	70	5	were	be	AUX
dti-1314	70	6	as	as	SCONJ
dti-1314	70	7	follows	follow	VERB
dti-1314	70	8	:	:	PUNCT
dti-1314	70	9	121	121	NUM
dti-1314	70	10	argininosuccinate	argininosuccinate	NOUN
dti-1314	70	11	synthetase	synthetase	NOUN
dti-1314	70	12	in	in	ADP
dti-1314	70	13	melanoma	melanoma	NOUN
dti-1314	70	14	drug	drug	NOUN
dti-1314	70	15	target	target	NOUN
dti-1314	70	16	insights	insight	NOUN
dti-1314	70	17	2007	2007	NUM
dti-1314	70	18	:	:	PUNCT
dti-1314	70	19	2	2	NUM
dti-1314	70	20	forward	forward	NOUN
dti-1314	70	21	primer	primer	NOUN
dti-1314	70	22	:	:	PUNCT
dti-1314	70	23	gaaggtgaaggtcggagtc	gaaggtgaaggtcggagtc	ADJ
dti-1314	70	24	;	;	PUNCT
dti-1314	70	25	reverse	reverse	NOUN
dti-1314	70	26	primer	primer	NOUN
dti-1314	70	27	:	:	PUNCT
dti-1314	70	28	caaagttgtcatggatgacc	caaagttgtcatggatgacc	ADJ
dti-1314	70	29	.	.	PUNCT
dti-1314	71	1	southernblot	southernblot	ADJ
dti-1314	71	2	analysis	analysis	NOUN
dti-1314	71	3	of	of	ADP
dti-1314	71	4	ass	ass	NOUN
dti-1314	71	5	gene	gene	NOUN
dti-1314	71	6	10	10	NUM
dti-1314	71	7	ug	ug	ADP
dti-1314	71	8	of	of	ADP
dti-1314	71	9	nuclear	nuclear	ADJ
dti-1314	71	10	dna	dna	PROPN
dti-1314	71	11	were	be	AUX
dti-1314	71	12	digested	digest	VERB
dti-1314	71	13	with	with	ADP
dti-1314	71	14	ecori	ecori	NOUN
dti-1314	71	15	restriction	restriction	NOUN
dti-1314	71	16	enzyme	enzyme	NOUN
dti-1314	71	17	and	and	CCONJ
dti-1314	71	18	electrophoresed	electrophorese	VERB
dti-1314	71	19	using	use	VERB
dti-1314	71	20	0.8	0.8	NUM
dti-1314	71	21	%	%	NOUN
dti-1314	71	22	agarose	agarose	NOUN
dti-1314	71	23	gels	gel	NOUN
dti-1314	71	24	at	at	ADP
dti-1314	71	25	3	3	NUM
dti-1314	71	26	cm	cm	NOUN
dti-1314	71	27	/	/	SYM
dti-1314	71	28	v	v	NOUN
dti-1314	71	29	for	for	ADP
dti-1314	71	30	10–16	10–16	NUM
dti-1314	71	31	hrs	hrs	NOUN
dti-1314	71	32	in	in	ADP
dti-1314	71	33	tae	tae	NOUN
dti-1314	71	34	buffer	buffer	NOUN
dti-1314	71	35	(	(	PUNCT
dti-1314	71	36	40	40	NUM
dti-1314	71	37	mm	mm	NOUN
dti-1314	71	38	tris	tris	NOUN
dti-1314	71	39	-	-	PUNCT
dti-1314	71	40	acetate	acetate	NOUN
dti-1314	71	41	,	,	PUNCT
dti-1314	71	42	1	1	NUM
dti-1314	71	43	mm	mm	NUM
dti-1314	71	44	edta	edta	NOUN
dti-1314	71	45	,	,	PUNCT
dti-1314	71	46	ph8.0	ph8.0	NUM
dti-1314	71	47	)	)	PUNCT
dti-1314	71	48	.	.	PUNCT
dti-1314	72	1	the	the	DET
dti-1314	72	2	nuclear	nuclear	ADJ
dti-1314	72	3	dna	dna	PROPN
dti-1314	72	4	was	be	AUX
dti-1314	72	5	transferred	transfer	VERB
dti-1314	72	6	onto	onto	ADP
dti-1314	72	7	a	a	DET
dti-1314	72	8	nylon	nylon	NOUN
dti-1314	72	9	fi	fi	NOUN
dti-1314	72	10	lter	lter	NOUN
dti-1314	72	11	(	(	PUNCT
dti-1314	72	12	hybond	hybond	NOUN
dti-1314	72	13	-	-	PUNCT
dti-1314	72	14	n	n	CCONJ
dti-1314	72	15	;	;	PUNCT
dti-1314	72	16	amersham	amersham	PROPN
dti-1314	72	17	)	)	PUNCT
dti-1314	72	18	and	and	CCONJ
dti-1314	72	19	hybridized	hybridize	VERB
dti-1314	72	20	with	with	ADP
dti-1314	72	21	32p	32p	ADJ
dti-1314	72	22	-	-	ADJ
dti-1314	72	23	dctp	dctp	ADJ
dti-1314	72	24	ass	ass	NOUN
dti-1314	72	25	probe	probe	NOUN
dti-1314	72	26	overnight	overnight	ADV
dti-1314	72	27	,	,	PUNCT
dti-1314	72	28	washed	wash	VERB
dti-1314	72	29	,	,	PUNCT
dti-1314	72	30	and	and	CCONJ
dti-1314	72	31	autoradiography	autoradiography	NOUN
dti-1314	72	32	was	be	AUX
dti-1314	72	33	performed	perform	VERB
dti-1314	72	34	.	.	PUNCT
dti-1314	73	1	ass	ass	NOUN
dti-1314	73	2	probe	probe	NOUN
dti-1314	73	3	was	be	AUX
dti-1314	73	4	generated	generate	VERB
dti-1314	73	5	from	from	ADP
dti-1314	73	6	bj-1	bj-1	ADV
dti-1314	73	7	cell	cell	NOUN
dti-1314	73	8	line	line	NOUN
dti-1314	73	9	.	.	PUNCT
dti-1314	74	1	briefl	briefl	NOUN
dti-1314	74	2	y	y	PROPN
dti-1314	74	3	,	,	PUNCT
dti-1314	74	4	the	the	DET
dti-1314	74	5	ass	ass	NOUN
dti-1314	74	6	pcr	pcr	NOUN
dti-1314	74	7	product	product	NOUN
dti-1314	74	8	was	be	AUX
dti-1314	74	9	obtained	obtain	VERB
dti-1314	74	10	using	use	VERB
dti-1314	74	11	the	the	DET
dti-1314	74	12	primers	primer	NOUN
dti-1314	74	13	mentioned	mention	VERB
dti-1314	74	14	above	above	ADV
dti-1314	74	15	,	,	PUNCT
dti-1314	74	16	then	then	ADV
dti-1314	74	17	eluted	elute	VERB
dti-1314	74	18	from	from	ADP
dti-1314	74	19	the	the	DET
dti-1314	74	20	agorose	agorose	ADJ
dti-1314	74	21	gel	gel	NOUN
dti-1314	74	22	using	use	VERB
dti-1314	74	23	the	the	DET
dti-1314	74	24	kit	kit	NOUN
dti-1314	74	25	from	from	ADP
dti-1314	74	26	qiagen	qiagen	NOUN
dti-1314	74	27	and	and	CCONJ
dti-1314	74	28	labeled	label	VERB
dti-1314	74	29	by	by	ADP
dti-1314	74	30	32p	32p	NOUN
dti-1314	74	31	-	-	ADJ
dti-1314	74	32	dctp	dctp	NOUN
dti-1314	74	33	using	use	VERB
dti-1314	74	34	random	random	ADJ
dti-1314	74	35	oligolabeling	oligolabeling	NOUN
dti-1314	74	36	technique	technique	NOUN
dti-1314	74	37	.	.	PUNCT
dti-1314	75	1	northernblot	northernblot	ADJ
dti-1314	75	2	analysis	analysis	NOUN
dti-1314	75	3	of	of	ADP
dti-1314	75	4	ass	ass	NOUN
dti-1314	75	5	gene	gene	NOUN
dti-1314	75	6	total	total	NOUN
dti-1314	75	7	rna	rna	PROPN
dti-1314	75	8	was	be	AUX
dti-1314	75	9	extracted	extract	VERB
dti-1314	75	10	using	use	VERB
dti-1314	75	11	the	the	DET
dti-1314	75	12	kit	kit	NOUN
dti-1314	75	13	from	from	ADP
dti-1314	75	14	invitrogen	invitrogen	PROPN
dti-1314	75	15	.	.	PUNCT
dti-1314	76	1	10	10	NUM
dti-1314	76	2	ug	ug	ADP
dti-1314	76	3	total	total	PROPN
dti-1314	76	4	rna	rna	PROPN
dti-1314	76	5	was	be	AUX
dti-1314	76	6	separated	separate	VERB
dti-1314	76	7	in	in	ADP
dti-1314	76	8	1	1	NUM
dti-1314	76	9	%	%	NOUN
dti-1314	76	10	agarose	agarose	NOUN
dti-1314	76	11	gel	gel	NOUN
dti-1314	76	12	in	in	ADP
dti-1314	76	13	mops	mop	NOUN
dti-1314	76	14	-formaldehyde	-formaldehyde	PROPN
dti-1314	76	15	buffer	buffer	NOUN
dti-1314	76	16	,	,	PUNCT
dti-1314	76	17	transferred	transfer	VERB
dti-1314	76	18	to	to	ADP
dti-1314	76	19	a	a	DET
dti-1314	76	20	nylon	nylon	NOUN
dti-1314	76	21	membrane	membrane	NOUN
dti-1314	76	22	(	(	PUNCT
dti-1314	76	23	hybond	hybond	NOUN
dti-1314	76	24	-	-	PUNCT
dti-1314	76	25	n	n	CCONJ
dti-1314	76	26	;	;	PUNCT
dti-1314	76	27	amersham	amersham	PROPN
dti-1314	76	28	)	)	PUNCT
dti-1314	76	29	and	and	CCONJ
dti-1314	76	30	hybridized	hybridize	VERB
dti-1314	76	31	with	with	ADP
dti-1314	76	32	32p	32p	NOUN
dti-1314	76	33	-	-	ADJ
dti-1314	76	34	dctp	dctp	NOUN
dti-1314	76	35	labeled	label	VERB
dti-1314	76	36	ass	ass	NOUN
dti-1314	76	37	probe	probe	NOUN
dti-1314	76	38	.	.	PUNCT
dti-1314	77	1	autoradiography	autoradiography	NOUN
dti-1314	77	2	was	be	AUX
dti-1314	77	3	carried	carry	VERB
dti-1314	77	4	out	out	ADP
dti-1314	77	5	.	.	PUNCT
dti-1314	78	1	westernblot	westernblot	NOUN
dti-1314	78	2	analysis	analysis	NOUN
dti-1314	78	3	of	of	ADP
dti-1314	78	4	ass	ass	NOUN
dti-1314	78	5	cells	cell	NOUN
dti-1314	78	6	were	be	AUX
dti-1314	78	7	lysed	lyse	VERB
dti-1314	78	8	with	with	ADP
dti-1314	78	9	ripa	ripa	ADJ
dti-1314	78	10	buffer	buffer	NOUN
dti-1314	78	11	(	(	PUNCT
dti-1314	78	12	10	10	NUM
dti-1314	78	13	mmtris	mmtris	VERB
dti-1314	78	14	ph7.4	ph7.4	PROPN
dti-1314	78	15	100	100	NUM
dti-1314	78	16	mm	mm	NOUN
dti-1314	78	17	nacl	nacl	NOUN
dti-1314	78	18	,	,	PUNCT
dti-1314	78	19	1	1	NUM
dti-1314	78	20	mm	mm	NUM
dti-1314	78	21	edta	edta	NOUN
dti-1314	78	22	,	,	PUNCT
dti-1314	78	23	20	20	NUM
dti-1314	78	24	mm	mm	PROPN
dti-1314	78	25	na4p2o7	na4p2o7	PROPN
dti-1314	78	26	,	,	PUNCT
dti-1314	78	27	2	2	NUM
dti-1314	78	28	mm	mm	NOUN
dti-1314	78	29	na3vo4	na3vo4	NOUN
dti-1314	78	30	,	,	PUNCT
dti-1314	78	31	1	1	NUM
dti-1314	78	32	%	%	NOUN
dti-1314	78	33	np-40	np-40	PRON
dti-1314	78	34	,	,	PUNCT
dti-1314	78	35	0.5	0.5	NUM
dti-1314	78	36	%	%	NOUN
dti-1314	78	37	deoxycholate	deoxycholate	NOUN
dti-1314	78	38	,	,	PUNCT
dti-1314	78	39	1	1	NUM
dti-1314	78	40	mm	mm	NOUN
dti-1314	78	41	pmsf	pmsf	NOUN
dti-1314	78	42	)	)	PUNCT
dti-1314	78	43	and	and	CCONJ
dti-1314	78	44	protease	protease	NOUN
dti-1314	78	45	inhibitor	inhibitor	NOUN
dti-1314	78	46	cocktail	cocktail	NOUN
dti-1314	78	47	from	from	ADP
dti-1314	78	48	sigma	sigma	PROPN
dti-1314	78	49	,	,	PUNCT
dti-1314	78	50	passed	pass	VERB
dti-1314	78	51	several	several	ADJ
dti-1314	78	52	times	time	NOUN
dti-1314	78	53	through	through	ADP
dti-1314	78	54	a	a	DET
dti-1314	78	55	23	23	NUM
dti-1314	78	56	g	g	NOUN
dti-1314	78	57	needle	needle	NOUN
dti-1314	78	58	,	,	PUNCT
dti-1314	78	59	and	and	CCONJ
dti-1314	78	60	centrifuged	centrifuge	VERB
dti-1314	78	61	.	.	PUNCT
dti-1314	79	1	the	the	DET
dti-1314	79	2	total	total	ADJ
dti-1314	79	3	protein	protein	NOUN
dti-1314	79	4	was	be	AUX
dti-1314	79	5	separated	separate	VERB
dti-1314	79	6	on	on	ADP
dti-1314	79	7	12	12	NUM
dti-1314	79	8	%	%	NOUN
dti-1314	79	9	sds	sds	NOUN
dti-1314	79	10	-	-	PUNCT
dti-1314	79	11	page	page	NOUN
dti-1314	79	12	,	,	PUNCT
dti-1314	79	13	transferred	transfer	VERB
dti-1314	79	14	onto	onto	ADP
dti-1314	79	15	membrane	membrane	NOUN
dti-1314	79	16	and	and	CCONJ
dti-1314	79	17	immunoblot	immunoblot	NOUN
dti-1314	79	18	with	with	ADP
dti-1314	79	19	a	a	DET
dti-1314	79	20	specifi	specifi	PROPN
dti-1314	79	21	c	c	NOUN
dti-1314	79	22	antibody	antibody	NOUN
dti-1314	79	23	and	and	CCONJ
dti-1314	79	24	detected	detect	VERB
dti-1314	79	25	by	by	ADP
dti-1314	79	26	chemiluminescence	chemiluminescence	NOUN
dti-1314	79	27	.	.	PUNCT
dti-1314	80	1	construction	construction	NOUN
dti-1314	80	2	of	of	ADP
dti-1314	80	3	human	human	ADJ
dti-1314	80	4	argininosuccinate	argininosuccinate	NOUN
dti-1314	80	5	synthetase	synthetase	NOUN
dti-1314	80	6	expression	expression	NOUN
dti-1314	80	7	vector	vector	NOUN
dti-1314	80	8	to	to	PART
dti-1314	80	9	construct	construct	VERB
dti-1314	80	10	pcdna3	pcdna3	NOUN
dti-1314	80	11	-	-	PUNCT
dti-1314	80	12	ass	ass	NOUN
dti-1314	80	13	,	,	PUNCT
dti-1314	80	14	we	we	PRON
dti-1314	80	15	amplified	amplify	VERB
dti-1314	80	16	the	the	DET
dti-1314	80	17	human	human	ADJ
dti-1314	80	18	argininosuccinate	argininosuccinate	NOUN
dti-1314	80	19	synthetase	synthetase	NOUN
dti-1314	80	20	mrna	mrna	PROPN
dti-1314	80	21	sequence	sequence	NOUN
dti-1314	80	22	from	from	ADP
dti-1314	80	23	79	79	NUM
dti-1314	80	24	to	to	ADP
dti-1314	80	25	1314	1314	NUM
dti-1314	80	26	nt	not	PART
dti-1314	80	27	(	(	PUNCT
dti-1314	80	28	using	use	VERB
dti-1314	80	29	genbank	genbank	NOUN
dti-1314	80	30	accession	accession	NOUN
dti-1314	80	31	number	number	NOUN
dti-1314	80	32	x01630	x01630	PROPN
dti-1314	80	33	as	as	ADP
dti-1314	80	34	the	the	DET
dti-1314	80	35	reference	reference	NOUN
dti-1314	80	36	)	)	PUNCT
dti-1314	80	37	by	by	ADP
dti-1314	80	38	pcr	pcr	PROPN
dti-1314	80	39	with	with	ADP
dti-1314	80	40	primer	primer	NOUN
dti-1314	80	41	pairs	pair	NOUN
dti-1314	80	42	containing	contain	VERB
dti-1314	80	43	sequences	sequence	NOUN
dti-1314	80	44	5’gcggccgc	5’gcggccgc	NUM
dti-1314	80	45	tccagcaaaggc	tccagcaaaggc	NOUN
dti-1314	80	46	tccgtgg	tccgtgg	NOUN
dti-1314	80	47	(	(	PUNCT
dti-1314	80	48	sense	sense	NOUN
dti-1314	80	49	;	;	PUNCT
dti-1314	80	50	underscore	underscore	NOUN
dti-1314	80	51	sequence	sequence	NOUN
dti-1314	80	52	contains	contain	VERB
dti-1314	80	53	the	the	DET
dti-1314	80	54	not	not	PART
dti-1314	80	55	i	i	PRON
dti-1314	80	56	site	site	NOUN
dti-1314	80	57	)	)	PUNCT
dti-1314	80	58	and	and	CCONJ
dti-1314	80	59	5’-gcggccgctatttggcagtgaccttgc	5’-gcggccgctatttggcagtgaccttgc	NUM
dti-1314	80	60	(	(	PUNCT
dti-1314	80	61	antisense	antisense	NOUN
dti-1314	80	62	;	;	PUNCT
dti-1314	80	63	underscore	underscore	NOUN
dti-1314	80	64	sequence	sequence	NOUN
dti-1314	80	65	contains	contain	VERB
dti-1314	80	66	not	not	PART
dti-1314	80	67	i	i	PRON
dti-1314	80	68	site	site	NOUN
dti-1314	80	69	)	)	PUNCT
dti-1314	80	70	using	use	VERB
dti-1314	80	71	human	human	ADJ
dti-1314	80	72	pancrease	pancrease	NOUN
dti-1314	80	73	cdna	cdna	PROPN
dti-1314	80	74	(	(	PUNCT
dti-1314	80	75	clonetech	clonetech	PROPN
dti-1314	80	76	,	,	PUNCT
dti-1314	80	77	mountain	mountain	NOUN
dti-1314	80	78	view	view	NOUN
dti-1314	80	79	,	,	PUNCT
dti-1314	80	80	ca	ca	NOUN
dti-1314	80	81	)	)	PUNCT
dti-1314	80	82	as	as	ADP
dti-1314	80	83	the	the	DET
dti-1314	80	84	template	template	NOUN
dti-1314	80	85	.	.	PUNCT
dti-1314	81	1	the	the	DET
dti-1314	81	2	pcr	pcr	ADJ
dti-1314	81	3	product	product	NOUN
dti-1314	81	4	was	be	AUX
dti-1314	81	5	cloned	clone	VERB
dti-1314	81	6	into	into	ADP
dti-1314	81	7	pcr	pcr	PROPN
dti-1314	81	8	®	®	PROPN
dti-1314	81	9	ii	ii	PROPN
dti-1314	81	10	-	-	ADJ
dti-1314	81	11	topo	topo	PROPN
dti-1314	81	12	vector	vector	NOUN
dti-1314	81	13	(	(	PUNCT
dti-1314	81	14	invitrogen	invitrogen	PROPN
dti-1314	81	15	)	)	PUNCT
dti-1314	81	16	.	.	PUNCT
dti-1314	82	1	the	the	DET
dti-1314	82	2	noti	noti	PROPN
dti-1314	82	3	fragment	fragment	PROPN
dti-1314	82	4	containing	contain	VERB
dti-1314	82	5	the	the	DET
dti-1314	82	6	respective	respective	ADJ
dti-1314	82	7	cdna	cdna	PROPN
dti-1314	82	8	was	be	AUX
dti-1314	82	9	then	then	ADV
dti-1314	82	10	transferred	transfer	VERB
dti-1314	82	11	into	into	ADP
dti-1314	82	12	the	the	DET
dti-1314	82	13	noti	noti	PROPN
dti-1314	82	14	site	site	NOUN
dti-1314	82	15	of	of	ADP
dti-1314	82	16	cin	cin	PROPN
dti-1314	82	17	-	-	PUNCT
dti-1314	82	18	ha	ha	INTJ
dti-1314	82	19	-	-	PUNCT
dti-1314	82	20	pcdna3	pcdna3	NOUN
dti-1314	82	21	vector	vector	NOUN
dti-1314	82	22	,	,	PUNCT
dti-1314	82	23	which	which	PRON
dti-1314	82	24	contains	contain	VERB
dti-1314	82	25	a	a	DET
dti-1314	82	26	hemagglutinin	hemagglutinin	ADJ
dti-1314	82	27	tag	tag	NOUN
dti-1314	82	28	,	,	PUNCT
dti-1314	82	29	enhancer	enhancer	NOUN
dti-1314	82	30	cin	cin	NOUN
dti-1314	82	31	sequence	sequence	NOUN
dti-1314	82	32	for	for	ADP
dti-1314	82	33	expression	expression	NOUN
dti-1314	82	34	,	,	PUNCT
dti-1314	82	35	and	and	CCONJ
dti-1314	82	36	a	a	DET
dti-1314	82	37	neomycin	neomycin	NOUN
dti-1314	82	38	resistance	resistance	NOUN
dti-1314	82	39	marker	marker	NOUN
dti-1314	82	40	for	for	ADP
dti-1314	82	41	transfection	transfection	NOUN
dti-1314	82	42	selection	selection	NOUN
dti-1314	82	43	.	.	PUNCT
dti-1314	83	1	transfection	transfection	NOUN
dti-1314	83	2	of	of	ADP
dti-1314	83	3	ass	ass	NOUN
dti-1314	83	4	gene	gene	NOUN
dti-1314	83	5	.	.	PUNCT
dti-1314	84	1	ass	ass	PROPN
dti-1314	84	2	cdna	cdna	PROPN
dti-1314	84	3	was	be	AUX
dti-1314	84	4	introduced	introduce	VERB
dti-1314	84	5	into	into	ADP
dti-1314	84	6	a375	a375	PROPN
dti-1314	84	7	and	and	CCONJ
dti-1314	84	8	a2058	a2058	NUM
dti-1314	84	9	cell	cell	NOUN
dti-1314	84	10	line	line	NOUN
dti-1314	84	11	using	use	VERB
dti-1314	84	12	lipofectamine	lipofectamine	NOUN
dti-1314	84	13	from	from	ADP
dti-1314	84	14	invitrogen	invitrogen	PROPN
dti-1314	84	15	and	and	CCONJ
dti-1314	84	16	selected	select	VERB
dti-1314	84	17	with	with	ADP
dti-1314	84	18	g-418	g-418	PROPN
dti-1314	84	19	.	.	PUNCT
dti-1314	85	1	these	these	DET
dti-1314	85	2	transfectants	transfectant	NOUN
dti-1314	85	3	were	be	AUX
dti-1314	85	4	then	then	ADV
dti-1314	85	5	tested	test	VERB
dti-1314	85	6	for	for	ADP
dti-1314	85	7	their	their	PRON
dti-1314	85	8	sensitivity	sensitivity	NOUN
dti-1314	85	9	to	to	ADP
dti-1314	85	10	adi	adi	NOUN
dti-1314	85	11	-	-	PUNCT
dti-1314	85	12	peg20	peg20	PROPN
dti-1314	85	13	.	.	PUNCT
dti-1314	86	1	results	result	VERB
dti-1314	86	2	growth	growth	VERB
dti-1314	86	3	inhibitory	inhibitory	ADJ
dti-1314	86	4	effect	effect	NOUN
dti-1314	86	5	of	of	ADP
dti-1314	86	6	adi	adi	NOUN
dti-1314	86	7	-	-	PUNCT
dti-1314	86	8	peg20	peg20	NOUN
dti-1314	86	9	the	the	DET
dti-1314	86	10	growth	growth	NOUN
dti-1314	86	11	inhibitory	inhibitory	ADJ
dti-1314	86	12	effect	effect	NOUN
dti-1314	86	13	as	as	ADV
dti-1314	86	14	well	well	ADV
dti-1314	86	15	as	as	ADP
dti-1314	86	16	the	the	DET
dti-1314	86	17	arginine	arginine	NOUN
dti-1314	86	18	and	and	CCONJ
dti-1314	86	19	citrulline	citrulline	NOUN
dti-1314	86	20	concentrations	concentration	NOUN
dti-1314	86	21	in	in	ADP
dti-1314	86	22	the	the	DET
dti-1314	86	23	media	medium	NOUN
dti-1314	86	24	are	be	AUX
dti-1314	86	25	shown	show	VERB
dti-1314	86	26	in	in	ADP
dti-1314	86	27	table	table	NOUN
dti-1314	86	28	i.	i.	NOUN
dti-1314	86	29	the	the	DET
dti-1314	86	30	id50	id50	PROPN
dti-1314	86	31	ranged	range	VERB
dti-1314	86	32	from	from	ADP
dti-1314	86	33	0.05	0.05	NUM
dti-1314	86	34	–	–	PUNCT
dti-1314	86	35	0.08	0.08	NUM
dti-1314	86	36	ug	ug	ADP
dti-1314	86	37	/	/	SYM
dti-1314	86	38	ml	ml	PROPN
dti-1314	86	39	.	.	PUNCT
dti-1314	87	1	however	however	ADV
dti-1314	87	2	,	,	PUNCT
dti-1314	87	3	there	there	PRON
dti-1314	87	4	are	be	VERB
dti-1314	87	5	no	no	DET
dti-1314	87	6	viable	viable	ADJ
dti-1314	87	7	cells	cell	NOUN
dti-1314	87	8	in	in	ADP
dti-1314	87	9	all	all	DET
dti-1314	87	10	three	three	NUM
dti-1314	87	11	cell	cell	NOUN
dti-1314	87	12	lines	line	NOUN
dti-1314	87	13	(	(	PUNCT
dti-1314	87	14	a375	a375	PROPN
dti-1314	87	15	,	,	PUNCT
dti-1314	87	16	sk	sk	NOUN
dti-1314	87	17	-	-	PUNCT
dti-1314	87	18	mel-2	mel-2	NUM
dti-1314	87	19	and	and	CCONJ
dti-1314	87	20	mel-1220	mel-1220	ADJ
dti-1314	87	21	)	)	PUNCT
dti-1314	87	22	after	after	ADP
dti-1314	87	23	exposure	exposure	NOUN
dti-1314	87	24	to	to	ADP
dti-1314	87	25	adi	adi	NOUN
dti-1314	87	26	-	-	PUNCT
dti-1314	87	27	peg20	peg20	PROPN
dti-1314	87	28	for	for	ADP
dti-1314	87	29	seven	seven	NUM
dti-1314	87	30	days	day	NOUN
dti-1314	87	31	,	,	PUNCT
dti-1314	87	32	whereas	whereas	SCONJ
dti-1314	87	33	in	in	ADP
dti-1314	87	34	a2058	a2058	PROPN
dti-1314	87	35	there	there	PRON
dti-1314	87	36	is	be	VERB
dti-1314	87	37	2–3	2–3	NUM
dti-1314	87	38	%	%	NOUN
dti-1314	87	39	viable	viable	ADJ
dti-1314	87	40	cell	cell	NOUN
dti-1314	87	41	left	leave	VERB
dti-1314	87	42	.	.	PUNCT
dti-1314	88	1	from	from	ADP
dti-1314	88	2	the	the	DET
dti-1314	88	3	id50	id50	PROPN
dti-1314	88	4	results	result	NOUN
dti-1314	88	5	,	,	PUNCT
dti-1314	88	6	it	it	PRON
dti-1314	88	7	appears	appear	VERB
dti-1314	88	8	that	that	SCONJ
dti-1314	88	9	in	in	ADP
dti-1314	88	10	sk	sk	NOUN
dti-1314	88	11	-	-	PUNCT
dti-1314	88	12	mel-2	mel-2	NUM
dti-1314	88	13	and	and	CCONJ
dti-1314	88	14	a2058	a2058	NUM
dti-1314	88	15	cell	cell	NOUN
dti-1314	88	16	lines	line	NOUN
dti-1314	88	17	require	require	VERB
dti-1314	88	18	more	more	ADJ
dti-1314	88	19	adi	adi	NOUN
dti-1314	88	20	-	-	PUNCT
dti-1314	88	21	peg20	peg20	NOUN
dti-1314	88	22	to	to	PART
dti-1314	88	23	deplete	deplete	VERB
dti-1314	88	24	arginine	arginine	NOUN
dti-1314	88	25	in	in	ADP
dti-1314	88	26	the	the	DET
dti-1314	88	27	media	medium	NOUN
dti-1314	88	28	.	.	PUNCT
dti-1314	89	1	at	at	ADP
dti-1314	89	2	72	72	NUM
dti-1314	89	3	hr	hr	NOUN
dti-1314	89	4	.	.	PUNCT
dti-1314	90	1	there	there	PRON
dti-1314	90	2	is	be	VERB
dti-1314	90	3	still	still	ADV
dti-1314	90	4	arginine	arginine	NOUN
dti-1314	90	5	remaining	remain	VERB
dti-1314	90	6	in	in	ADP
dti-1314	90	7	the	the	DET
dti-1314	90	8	media	medium	NOUN
dti-1314	90	9	(	(	PUNCT
dti-1314	90	10	12.8	12.8	NUM
dti-1314	90	11	um	um	INTJ
dti-1314	90	12	for	for	ADP
dti-1314	90	13	skmel-2	skmel-2	PROPN
dti-1314	90	14	and	and	CCONJ
dti-1314	90	15	23.5	23.5	NUM
dti-1314	90	16	um	um	INTJ
dti-1314	90	17	for	for	ADP
dti-1314	90	18	a2058	a2058	NOUN
dti-1314	90	19	)	)	PUNCT
dti-1314	90	20	whereas	whereas	SCONJ
dti-1314	90	21	in	in	ADP
dti-1314	90	22	a375	a375	PROPN
dti-1314	90	23	and	and	CCONJ
dti-1314	90	24	mel-1220	mel-1220	VERB
dti-1314	90	25	there	there	PRON
dti-1314	90	26	is	be	VERB
dti-1314	90	27	no	no	DET
dti-1314	90	28	detectable	detectable	ADJ
dti-1314	90	29	arginine	arginine	NOUN
dti-1314	90	30	level	level	NOUN
dti-1314	90	31	in	in	ADP
dti-1314	90	32	the	the	DET
dti-1314	90	33	media	medium	NOUN
dti-1314	90	34	.	.	PUNCT
dti-1314	91	1	these	these	DET
dti-1314	91	2	fi	fi	NOUN
dti-1314	91	3	ndings	nding	NOUN
dti-1314	91	4	may	may	AUX
dti-1314	91	5	be	be	AUX
dti-1314	91	6	related	relate	VERB
dti-1314	91	7	to	to	ADP
dti-1314	91	8	the	the	DET
dti-1314	91	9	capability	capability	NOUN
dti-1314	91	10	of	of	ADP
dti-1314	91	11	the	the	DET
dti-1314	91	12	intracellular	intracellular	ADJ
dti-1314	91	13	machinery	machinery	NOUN
dti-1314	91	14	to	to	PART
dti-1314	91	15	maintain	maintain	VERB
dti-1314	91	16	ass	ass	NOUN
dti-1314	91	17	actin	actin	NOUN
dti-1314	91	18	a3	a3	NOUN
dti-1314	91	19	75	75	NUM
dti-1314	91	20	s	s	NOUN
dti-1314	91	21	km	km	PROPN
dti-1314	91	22	el	el	PROPN
dti-1314	91	23	-2	-2	PROPN
dti-1314	91	24	a2	a2	PROPN
dti-1314	91	25	05	05	NUM
dti-1314	91	26	8	8	NUM
dti-1314	91	27	m	m	NOUN
dti-1314	91	28	el	el	PROPN
dti-1314	91	29	-1	-1	PROPN
dti-1314	91	30	22	22	NUM
dti-1314	91	31	0	0	NUM
dti-1314	91	32	bj	bj	NOUN
dti-1314	91	33	-1	-1	PRON
dti-1314	91	34	n	n	CCONJ
dti-1314	91	35	sc	sc	PROPN
dti-1314	91	36	lc	lc	PROPN
dti-1314	91	37	s	s	PART
dti-1314	91	38	figure	figure	NOUN
dti-1314	91	39	1	1	NUM
dti-1314	91	40	.	.	PUNCT
dti-1314	92	1	immunoblot	immunoblot	NOUN
dti-1314	92	2	of	of	ADP
dti-1314	92	3	ass	ass	NOUN
dti-1314	92	4	protein	protein	NOUN
dti-1314	92	5	using	use	VERB
dti-1314	92	6	commercially	commercially	ADV
dti-1314	92	7	available	available	ADJ
dti-1314	92	8	monoclonal	monoclonal	NOUN
dti-1314	92	9	antibody	antibody	NOUN
dti-1314	92	10	(	(	PUNCT
dti-1314	92	11	bd	bd	NOUN
dti-1314	92	12	-	-	NOUN
dti-1314	92	13	bioscience	bioscience	NOUN
dti-1314	92	14	)	)	PUNCT
dti-1314	92	15	.	.	PUNCT
dti-1314	93	1	all	all	DET
dti-1314	93	2	four	four	NUM
dti-1314	93	3	melanoma	melanoma	NOUN
dti-1314	93	4	cell	cell	NOUN
dti-1314	93	5	lines	line	NOUN
dti-1314	93	6	(	(	PUNCT
dti-1314	93	7	a375	a375	PROPN
dti-1314	93	8	,	,	PUNCT
dti-1314	93	9	sk	sk	PROPN
dti-1314	93	10	-	-	PUNCT
dti-1314	93	11	mel2	mel2	NOUN
dti-1314	93	12	,	,	PUNCT
dti-1314	93	13	a2058	a2058	NUM
dti-1314	93	14	and	and	CCONJ
dti-1314	93	15	mel-1220	mel-1220	ADJ
dti-1314	93	16	)	)	PUNCT
dti-1314	93	17	do	do	AUX
dti-1314	93	18	not	not	PART
dti-1314	93	19	express	express	VERB
dti-1314	93	20	ass	ass	NOUN
dti-1314	93	21	protein	protein	NOUN
dti-1314	93	22	whereas	whereas	SCONJ
dti-1314	93	23	nsclcs	nsclcs	NOUN
dti-1314	93	24	and	and	CCONJ
dti-1314	93	25	bj-1	bj-1	ADV
dti-1314	93	26	possess	possess	VERB
dti-1314	93	27	high	high	ADJ
dti-1314	93	28	levels	level	NOUN
dti-1314	93	29	of	of	ADP
dti-1314	93	30	ass	ass	NOUN
dti-1314	93	31	protein	protein	NOUN
dti-1314	93	32	.	.	PUNCT
dti-1314	94	1	actin	actin	PROPN
dti-1314	94	2	was	be	AUX
dti-1314	94	3	used	use	VERB
dti-1314	94	4	as	as	ADP
dti-1314	94	5	control	control	NOUN
dti-1314	94	6	.	.	PUNCT
dti-1314	95	1	122	122	NUM
dti-1314	95	2	savaraj	savaraj	VERB
dti-1314	95	3	et	et	PROPN
dti-1314	95	4	al	al	PROPN
dti-1314	95	5	drug	drug	PROPN
dti-1314	95	6	target	target	NOUN
dti-1314	95	7	insights	insight	NOUN
dti-1314	95	8	2007	2007	NUM
dti-1314	95	9	:	:	SYM
dti-1314	95	10	2	2	NUM
dti-1314	95	11	arginine	arginine	NOUN
dti-1314	95	12	either	either	CCONJ
dti-1314	95	13	by	by	ADP
dti-1314	95	14	degradation	degradation	NOUN
dti-1314	95	15	of	of	ADP
dti-1314	95	16	certain	certain	ADJ
dti-1314	95	17	unessential	unessential	ADJ
dti-1314	95	18	proteins	protein	NOUN
dti-1314	95	19	or	or	CCONJ
dti-1314	95	20	turning	turn	VERB
dti-1314	95	21	on	on	ADP
dti-1314	95	22	ass	ass	NOUN
dti-1314	95	23	or	or	CCONJ
dti-1314	95	24	other	other	ADJ
dti-1314	95	25	unknown	unknown	ADJ
dti-1314	95	26	mechanisms	mechanism	NOUN
dti-1314	95	27	.	.	PUNCT
dti-1314	96	1	all	all	DET
dti-1314	96	2	these	these	DET
dti-1314	96	3	4	4	NUM
dti-1314	96	4	melanoma	melanoma	NOUN
dti-1314	96	5	cell	cell	NOUN
dti-1314	96	6	lines	line	NOUN
dti-1314	96	7	do	do	AUX
dti-1314	96	8	not	not	PART
dti-1314	96	9	express	express	VERB
dti-1314	96	10	ass	ass	NOUN
dti-1314	96	11	protein	protein	NOUN
dti-1314	96	12	(	(	PUNCT
dti-1314	96	13	as	as	SCONJ
dti-1314	96	14	detected	detect	VERB
dti-1314	96	15	by	by	ADP
dti-1314	96	16	westernblot	westernblot	NOUN
dti-1314	96	17	,	,	PUNCT
dti-1314	96	18	fig.1	fig.1	PROPN
dti-1314	96	19	)	)	PUNCT
dti-1314	96	20	and	and	CCONJ
dti-1314	96	21	neither	neither	CCONJ
dti-1314	96	22	at	at	ADP
dti-1314	96	23	the	the	DET
dti-1314	96	24	transcriptional	transcriptional	ADJ
dti-1314	96	25	levels	level	NOUN
dti-1314	96	26	as	as	SCONJ
dti-1314	96	27	detected	detect	VERB
dti-1314	96	28	by	by	ADP
dti-1314	96	29	northernblot	northernblot	ADJ
dti-1314	96	30	analysis	analysis	NOUN
dti-1314	96	31	.	.	PUNCT
dti-1314	97	1	this	this	DET
dti-1314	97	2	data	datum	NOUN
dti-1314	97	3	also	also	ADV
dti-1314	97	4	correspond	correspond	VERB
dti-1314	97	5	to	to	ADP
dti-1314	97	6	what	what	PRON
dti-1314	97	7	has	have	AUX
dti-1314	97	8	been	be	AUX
dti-1314	97	9	reported	report	VERB
dti-1314	97	10	in	in	ADP
dti-1314	97	11	the	the	DET
dti-1314	97	12	literature	literature	NOUN
dti-1314	97	13	(	(	PUNCT
dti-1314	97	14	dillon	dillon	PROPN
dti-1314	97	15	et	et	PROPN
dti-1314	97	16	al	al	PROPN
dti-1314	97	17	.	.	PROPN
dti-1314	97	18	2004	2004	NUM
dti-1314	97	19	;	;	PUNCT
dti-1314	97	20	ensor	ensor	PROPN
dti-1314	97	21	et	et	PROPN
dti-1314	97	22	al	al	PROPN
dti-1314	97	23	.	.	PROPN
dti-1314	97	24	2002	2002	NUM
dti-1314	97	25	)	)	PUNCT
dti-1314	97	26	.	.	PUNCT
dti-1314	98	1	however	however	ADV
dti-1314	98	2	,	,	PUNCT
dti-1314	98	3	the	the	DET
dti-1314	98	4	ass	ass	NOUN
dti-1314	98	5	dna	dna	NOUN
dti-1314	98	6	can	can	AUX
dti-1314	98	7	be	be	AUX
dti-1314	98	8	detected	detect	VERB
dti-1314	98	9	readily	readily	ADV
dti-1314	98	10	by	by	ADP
dti-1314	98	11	southernblot	southernblot	ADJ
dti-1314	98	12	analysis	analysis	NOUN
dti-1314	98	13	(	(	PUNCT
dti-1314	98	14	fig	fig	NOUN
dti-1314	98	15	.	.	PUNCT
dti-1314	99	1	2	2	NUM
dti-1314	99	2	)	)	PUNCT
dti-1314	99	3	.	.	PUNCT
dti-1314	100	1	thus	thus	ADV
dti-1314	100	2	,	,	PUNCT
dti-1314	100	3	lack	lack	NOUN
dti-1314	100	4	of	of	ADP
dti-1314	100	5	ass	ass	NOUN
dti-1314	100	6	expression	expression	NOUN
dti-1314	100	7	is	be	AUX
dti-1314	100	8	not	not	PART
dti-1314	100	9	from	from	ADP
dti-1314	100	10	gene	gene	NOUN
dti-1314	100	11	deletion	deletion	NOUN
dti-1314	100	12	.	.	PUNCT
dti-1314	101	1	in	in	ADP
dti-1314	101	2	contrast	contrast	NOUN
dti-1314	101	3	,	,	PUNCT
dti-1314	101	4	degradation	degradation	NOUN
dti-1314	101	5	of	of	ADP
dti-1314	101	6	arginine	arginine	NOUN
dti-1314	101	7	by	by	ADP
dti-1314	101	8	adi	adi	PROPN
dti-1314	101	9	-	-	PUNCT
dti-1314	101	10	peg20	peg20	PROPN
dti-1314	101	11	did	do	AUX
dti-1314	101	12	not	not	PART
dti-1314	101	13	have	have	VERB
dti-1314	101	14	growth	growth	NOUN
dti-1314	101	15	inhibitory	inhibitory	ADJ
dti-1314	101	16	effect	effect	NOUN
dti-1314	101	17	on	on	ADP
dti-1314	101	18	normal	normal	ADJ
dti-1314	101	19	fi	fi	NOUN
dti-1314	101	20	broblast	broblast	ADJ
dti-1314	101	21	bj-1	bj-1	NOUN
dti-1314	101	22	and	and	CCONJ
dti-1314	101	23	nsclcs	nsclcs	NOUN
dti-1314	101	24	cell	cell	NOUN
dti-1314	101	25	line	line	NOUN
dti-1314	101	26	(	(	PUNCT
dti-1314	101	27	table	table	NOUN
dti-1314	101	28	1	1	NUM
dti-1314	101	29	)	)	PUNCT
dti-1314	101	30	.	.	PUNCT
dti-1314	102	1	these	these	DET
dti-1314	102	2	two	two	NUM
dti-1314	102	3	cell	cell	NOUN
dti-1314	102	4	lines	line	NOUN
dti-1314	102	5	possess	possess	VERB
dti-1314	102	6	high	high	ADJ
dti-1314	102	7	levels	level	NOUN
dti-1314	102	8	of	of	ADP
dti-1314	102	9	ass	ass	NOUN
dti-1314	102	10	and	and	CCONJ
dti-1314	102	11	hence	hence	ADV
dti-1314	102	12	are	be	AUX
dti-1314	102	13	able	able	ADJ
dti-1314	102	14	to	to	PART
dti-1314	102	15	synthesize	synthesize	VERB
dti-1314	102	16	arginine	arginine	NOUN
dti-1314	102	17	from	from	ADP
dti-1314	102	18	citrulline	citrulline	NOUN
dti-1314	102	19	.	.	PUNCT
dti-1314	103	1	these	these	DET
dti-1314	103	2	two	two	NUM
dti-1314	103	3	cell	cell	NOUN
dti-1314	103	4	lines	line	NOUN
dti-1314	103	5	also	also	ADV
dti-1314	103	6	have	have	VERB
dti-1314	103	7	arginine	arginine	NOUN
dti-1314	103	8	in	in	ADP
dti-1314	103	9	the	the	DET
dti-1314	103	10	media	medium	NOUN
dti-1314	103	11	at	at	ADP
dti-1314	103	12	0.05	0.05	NUM
dti-1314	103	13	ug	ug	ADP
dti-1314	103	14	/	/	SYM
dti-1314	103	15	ml	ml	PROPN
dti-1314	103	16	of	of	ADP
dti-1314	103	17	adi	adi	NOUN
dti-1314	103	18	-	-	PUNCT
dti-1314	103	19	peg20	peg20	PROPN
dti-1314	103	20	.	.	PUNCT
dti-1314	104	1	at	at	ADP
dti-1314	104	2	this	this	DET
dti-1314	104	3	concentration	concentration	NOUN
dti-1314	104	4	there	there	PRON
dti-1314	104	5	is	be	VERB
dti-1314	104	6	no	no	DET
dti-1314	104	7	arginine	arginine	NOUN
dti-1314	104	8	in	in	ADP
dti-1314	104	9	the	the	DET
dti-1314	104	10	media	medium	NOUN
dti-1314	104	11	when	when	SCONJ
dti-1314	104	12	emem	emem	ADJ
dti-1314	104	13	media	medium	NOUN
dti-1314	104	14	was	be	AUX
dti-1314	104	15	incubated	incubate	VERB
dti-1314	104	16	with	with	ADP
dti-1314	104	17	adi	adi	NOUN
dti-1314	104	18	-	-	PUNCT
dti-1314	104	19	peg20	peg20	PROPN
dti-1314	104	20	alone	alone	ADJ
dti-1314	104	21	with	with	ADP
dti-1314	104	22	no	no	DET
dti-1314	104	23	cells	cell	NOUN
dti-1314	104	24	for	for	ADP
dti-1314	104	25	3	3	NUM
dti-1314	104	26	days	day	NOUN
dti-1314	104	27	.	.	PUNCT
dti-1314	105	1	adi	adi	PROPN
dti-1314	105	2	induces	induce	VERB
dti-1314	105	3	apoptosis	apoptosis	NOUN
dti-1314	105	4	in	in	ADP
dti-1314	105	5	melanoma	melanoma	NOUN
dti-1314	105	6	cell	cell	NOUN
dti-1314	105	7	line	line	NOUN
dti-1314	105	8	we	we	PRON
dti-1314	105	9	have	have	AUX
dti-1314	105	10	exposed	expose	VERB
dti-1314	105	11	melanoma	melanoma	NOUN
dti-1314	105	12	cells	cell	NOUN
dti-1314	105	13	to	to	PART
dti-1314	105	14	arginine	arginine	VERB
dti-1314	105	15	free	free	ADJ
dti-1314	105	16	emem	emem	ADJ
dti-1314	105	17	media	medium	NOUN
dti-1314	105	18	with	with	ADP
dti-1314	105	19	citrulline	citrulline	NOUN
dti-1314	105	20	and	and	CCONJ
dti-1314	105	21	nh4cl	nh4cl	NOUN
dti-1314	105	22	supplement	supplement	NOUN
dti-1314	105	23	or	or	CCONJ
dti-1314	105	24	adi	adi	NOUN
dti-1314	105	25	at	at	ADP
dti-1314	105	26	0.05	0.05	NUM
dti-1314	105	27	ug	ug	ADP
dti-1314	105	28	/	/	SYM
dti-1314	105	29	ml	ml	NOUN
dti-1314	105	30	for	for	ADP
dti-1314	105	31	3	3	NUM
dti-1314	105	32	days	day	NOUN
dti-1314	105	33	and	and	CCONJ
dti-1314	105	34	assay	assay	VERB
dti-1314	105	35	for	for	ADP
dti-1314	105	36	apoptosis	apoptosis	NOUN
dti-1314	105	37	.	.	PUNCT
dti-1314	106	1	the	the	DET
dti-1314	106	2	results	result	NOUN
dti-1314	106	3	are	be	AUX
dti-1314	106	4	shown	show	VERB
dti-1314	106	5	in	in	ADP
dti-1314	106	6	figure	figure	NOUN
dti-1314	106	7	3a	3a	PROPN
dti-1314	106	8	&	&	CCONJ
dti-1314	106	9	3b	3b	NUM
dti-1314	106	10	.	.	PUNCT
dti-1314	107	1	all	all	DET
dti-1314	107	2	melanoma	melanoma	NOUN
dti-1314	107	3	cell	cell	NOUN
dti-1314	107	4	lines	line	NOUN
dti-1314	107	5	undergo	undergo	VERB
dti-1314	107	6	apoptosis	apoptosis	NOUN
dti-1314	107	7	by	by	ADP
dti-1314	107	8	both	both	DET
dti-1314	107	9	parp	parp	ADJ
dti-1314	107	10	assay	assay	NOUN
dti-1314	107	11	and	and	CCONJ
dti-1314	107	12	in	in	ADP
dti-1314	107	13	situ	situ	ADJ
dti-1314	107	14	end	end	NOUN
dti-1314	107	15	labeling	labeling	NOUN
dti-1314	107	16	assay	assay	VERB
dti-1314	107	17	whereas	whereas	SCONJ
dti-1314	107	18	bj-1	bj-1	ADV
dti-1314	107	19	and	and	CCONJ
dti-1314	107	20	nsclcs	nsclcs	NOUN
dti-1314	107	21	cells	cell	NOUN
dti-1314	107	22	do	do	AUX
dti-1314	107	23	not	not	PART
dti-1314	107	24	undergo	undergo	VERB
dti-1314	107	25	apoptosis	apoptosis	NOUN
dti-1314	107	26	(	(	PUNCT
dti-1314	107	27	data	datum	NOUN
dti-1314	107	28	not	not	PART
dti-1314	107	29	shown	show	VERB
dti-1314	107	30	)	)	PUNCT
dti-1314	107	31	.	.	PUNCT
dti-1314	108	1	arginine	arginine	NOUN
dti-1314	108	2	deprivation	deprivation	NOUN
dti-1314	108	3	induces	induce	VERB
dti-1314	108	4	melanoma	melanoma	NOUN
dti-1314	108	5	ass	ass	NOUN
dti-1314	108	6	gene	gene	NOUN
dti-1314	108	7	expression	expression	NOUN
dti-1314	108	8	it	it	PRON
dti-1314	108	9	has	have	AUX
dti-1314	108	10	been	be	AUX
dti-1314	108	11	shown	show	VERB
dti-1314	108	12	that	that	SCONJ
dti-1314	108	13	arginine	arginine	NOUN
dti-1314	108	14	levels	level	NOUN
dti-1314	108	15	can	can	AUX
dti-1314	108	16	regulate	regulate	VERB
dti-1314	108	17	ass	ass	NOUN
dti-1314	108	18	expression	expression	NOUN
dti-1314	108	19	in	in	ADP
dti-1314	108	20	lymphoblastoma	lymphoblastoma	ADJ
dti-1314	108	21	cells	cell	NOUN
dti-1314	108	22	and	and	CCONJ
dti-1314	108	23	epithelial	epithelial	ADJ
dti-1314	108	24	cells	cell	NOUN
dti-1314	108	25	(	(	PUNCT
dti-1314	108	26	jackson	jackson	PROPN
dti-1314	108	27	et	et	PROPN
dti-1314	108	28	al	al	PROPN
dti-1314	108	29	.	.	PROPN
dti-1314	108	30	1996	1996	NUM
dti-1314	108	31	;	;	PUNCT
dti-1314	108	32	philip	philip	PROPN
dti-1314	108	33	et	et	PROPN
dti-1314	108	34	al	al	PROPN
dti-1314	108	35	.	.	PROPN
dti-1314	108	36	2003	2003	NUM
dti-1314	108	37	)	)	PUNCT
dti-1314	108	38	.	.	PUNCT
dti-1314	109	1	however	however	ADV
dti-1314	109	2	,	,	PUNCT
dti-1314	109	3	whether	whether	SCONJ
dti-1314	109	4	this	this	DET
dti-1314	109	5	phenomenon	phenomenon	NOUN
dti-1314	109	6	occurs	occur	VERB
dti-1314	109	7	in	in	ADP
dti-1314	109	8	melanoma	melanoma	NOUN
dti-1314	109	9	cells	cell	NOUN
dti-1314	109	10	which	which	PRON
dti-1314	109	11	lack	lack	VERB
dti-1314	109	12	ass	ass	NOUN
dti-1314	109	13	expression	expression	NOUN
dti-1314	109	14	is	be	AUX
dti-1314	109	15	not	not	PART
dti-1314	109	16	known	know	VERB
dti-1314	109	17	.	.	PUNCT
dti-1314	110	1	we	we	PRON
dti-1314	110	2	have	have	AUX
dti-1314	110	3	studied	study	VERB
dti-1314	110	4	this	this	DET
dti-1314	110	5	possibility	possibility	NOUN
dti-1314	110	6	by	by	ADP
dti-1314	110	7	exposing	expose	VERB
dti-1314	110	8	four	four	NUM
dti-1314	110	9	melanoma	melanoma	NOUN
dti-1314	110	10	cell	cell	NOUN
dti-1314	110	11	lines	line	NOUN
dti-1314	110	12	(	(	PUNCT
dti-1314	110	13	a375	a375	PROPN
dti-1314	110	14	,	,	PUNCT
dti-1314	110	15	sk	sk	NOUN
dti-1314	110	16	-	-	PUNCT
dti-1314	110	17	mel-2	mel-2	NOUN
dti-1314	110	18	,	,	PUNCT
dti-1314	110	19	a2058	a2058	NUM
dti-1314	110	20	and	and	CCONJ
dti-1314	110	21	mel-1220	mel-1220	VERB
dti-1314	110	22	)	)	PUNCT
dti-1314	110	23	to	to	ADP
dti-1314	110	24	adi	adi	NOUN
dti-1314	110	25	-	-	PUNCT
dti-1314	110	26	peg20	peg20	PROPN
dti-1314	110	27	for	for	ADP
dti-1314	110	28	3	3	NUM
dti-1314	110	29	days	day	NOUN
dti-1314	110	30	and	and	CCONJ
dti-1314	110	31	assay	assay	VERB
dti-1314	110	32	for	for	ADP
dti-1314	110	33	ass	ass	NOUN
dti-1314	110	34	expression	expression	NOUN
dti-1314	110	35	.	.	PUNCT
dti-1314	111	1	the	the	DET
dti-1314	111	2	results	result	NOUN
dti-1314	111	3	are	be	AUX
dti-1314	111	4	shown	show	VERB
dti-1314	111	5	in	in	ADP
dti-1314	111	6	figure	figure	NOUN
dti-1314	111	7	4	4	NUM
dti-1314	111	8	.	.	PUNCT
dti-1314	112	1	it	it	PRON
dti-1314	112	2	is	be	AUX
dti-1314	112	3	of	of	ADP
dti-1314	112	4	interest	interest	NOUN
dti-1314	112	5	that	that	SCONJ
dti-1314	112	6	despite	despite	SCONJ
dti-1314	112	7	the	the	DET
dti-1314	112	8	similar	similar	ADJ
dti-1314	112	9	levels	level	NOUN
dti-1314	112	10	of	of	ADP
dti-1314	112	11	arginine	arginine	NOUN
dti-1314	112	12	deprivation	deprivation	NOUN
dti-1314	112	13	,	,	PUNCT
dti-1314	112	14	the	the	DET
dti-1314	112	15	levels	level	NOUN
dti-1314	112	16	of	of	ADP
dti-1314	112	17	ass	ass	NOUN
dti-1314	112	18	expression	expression	NOUN
dti-1314	112	19	as	as	SCONJ
dti-1314	112	20	detected	detect	VERB
dti-1314	112	21	by	by	ADP
dti-1314	112	22	westernblot	westernblot	NOUN
dti-1314	112	23	are	be	AUX
dti-1314	112	24	different	different	ADJ
dti-1314	112	25	.	.	PUNCT
dti-1314	113	1	a2058	a2058	PROPN
dti-1314	113	2	has	have	VERB
dti-1314	113	3	more	more	ADJ
dti-1314	113	4	ass	ass	NOUN
dti-1314	113	5	expression	expression	NOUN
dti-1314	113	6	(	(	PUNCT
dti-1314	113	7	2.76	2.76	NUM
dti-1314	113	8	fold	fold	NOUN
dti-1314	113	9	)	)	PUNCT
dti-1314	113	10	followed	follow	VERB
dti-1314	113	11	by	by	ADP
dti-1314	113	12	sk	sk	NOUN
dti-1314	113	13	-	-	PUNCT
dti-1314	113	14	mel-2	mel-2	PUNCT
dti-1314	113	15	(	(	PUNCT
dti-1314	113	16	2.03	2.03	NUM
dti-1314	113	17	)	)	PUNCT
dti-1314	113	18	and	and	CCONJ
dti-1314	113	19	a375(1.52	a375(1.52	ADJ
dti-1314	113	20	)	)	PUNCT
dti-1314	113	21	while	while	SCONJ
dti-1314	113	22	mel-1220	mel-1220	NOUN
dti-1314	113	23	is	be	AUX
dti-1314	113	24	unable	unable	ADJ
dti-1314	113	25	to	to	PART
dti-1314	113	26	turn	turn	VERB
dti-1314	113	27	on	on	ADP
dti-1314	113	28	ass	ass	NOUN
dti-1314	113	29	gene	gene	NOUN
dti-1314	113	30	.	.	PUNCT
dti-1314	114	1	to	to	PART
dti-1314	114	2	further	far	ADV
dti-1314	114	3	confi	confi	VERB
dti-1314	114	4	rm	rm	PROPN
dti-1314	114	5	this	this	DET
dti-1314	114	6	fi	fi	NOUN
dti-1314	114	7	nding	nde	VERB
dti-1314	114	8	we	we	PRON
dti-1314	114	9	have	have	AUX
dti-1314	114	10	cultured	culture	VERB
dti-1314	114	11	all	all	DET
dti-1314	114	12	four	four	NUM
dti-1314	114	13	cell	cell	NOUN
dti-1314	114	14	lines	line	NOUN
dti-1314	114	15	in	in	ADP
dti-1314	114	16	the	the	DET
dti-1314	114	17	arginine	arginine	NOUN
dti-1314	114	18	free	free	ADJ
dti-1314	114	19	media	medium	NOUN
dti-1314	114	20	with	with	ADP
dti-1314	114	21	or	or	CCONJ
dti-1314	114	22	without	without	ADP
dti-1314	114	23	citrulline	citrulline	NOUN
dti-1314	114	24	(	(	PUNCT
dti-1314	114	25	0.4	0.4	NUM
dti-1314	114	26	um	um	INTJ
dti-1314	114	27	)	)	PUNCT
dti-1314	114	28	and	and	CCONJ
dti-1314	114	29	nh4cl	nh4cl	NUM
dti-1314	114	30	(	(	PUNCT
dti-1314	114	31	0.4	0.4	NUM
dti-1314	114	32	um	um	INTJ
dti-1314	114	33	)	)	PUNCT
dti-1314	114	34	for	for	ADP
dti-1314	114	35	72	72	NUM
dti-1314	114	36	hr	hr	NOUN
dti-1314	114	37	.	.	PUNCT
dti-1314	115	1	as	as	ADV
dti-1314	115	2	well	well	ADV
dti-1314	115	3	as	as	ADP
dti-1314	115	4	using	use	VERB
dti-1314	115	5	mem	mem	ADJ
dti-1314	115	6	media	medium	NOUN
dti-1314	115	7	which	which	PRON
dti-1314	115	8	has	have	AUX
dti-1314	115	9	been	be	AUX
dti-1314	115	10	incubated	incubate	VERB
dti-1314	115	11	with	with	ADP
dti-1314	115	12	0.05	0.05	NUM
dti-1314	115	13	ug	ug	ADP
dti-1314	115	14	of	of	ADP
dti-1314	115	15	adi	adi	NOUN
dti-1314	115	16	-	-	PUNCT
dti-1314	115	17	peg20	peg20	PROPN
dti-1314	115	18	for	for	ADP
dti-1314	115	19	72	72	NUM
dti-1314	115	20	hr	hr	NOUN
dti-1314	115	21	.	.	PUNCT
dti-1314	116	1	to	to	ADP
dti-1314	116	2	deplete	deplete	NOUN
dti-1314	116	3	arginine	arginine	NOUN
dti-1314	116	4	.	.	PUNCT
dti-1314	117	1	at	at	ADP
dti-1314	117	2	24	24	NUM
dti-1314	117	3	,	,	PUNCT
dti-1314	117	4	48	48	NUM
dti-1314	117	5	and	and	CCONJ
dti-1314	117	6	72	72	NUM
dti-1314	117	7	hr	hr	NOUN
dti-1314	117	8	.	.	PROPN
dti-1314	117	9	,	,	PUNCT
dti-1314	117	10	cells	cell	NOUN
dti-1314	117	11	were	be	AUX
dti-1314	117	12	harvested	harvest	VERB
dti-1314	117	13	and	and	CCONJ
dti-1314	117	14	assayed	assayed	ADJ
dti-1314	117	15	for	for	ADP
dti-1314	117	16	ass	ass	NOUN
dti-1314	117	17	expression	expression	NOUN
dti-1314	117	18	.	.	PUNCT
dti-1314	118	1	after	after	SCONJ
dti-1314	118	2	72	72	NUM
dti-1314	118	3	hrs	hrs	NOUN
dti-1314	118	4	cells	cell	NOUN
dti-1314	118	5	were	be	AUX
dti-1314	118	6	placed	place	VERB
dti-1314	118	7	on	on	ADP
dti-1314	118	8	normal	normal	ADJ
dti-1314	118	9	emem	emem	ADJ
dti-1314	118	10	media	medium	NOUN
dti-1314	118	11	.	.	PUNCT
dti-1314	119	1	at	at	ADP
dti-1314	119	2	24	24	NUM
dti-1314	119	3	,	,	PUNCT
dti-1314	119	4	48	48	NUM
dti-1314	119	5	and	and	CCONJ
dti-1314	119	6	72	72	NUM
dti-1314	119	7	hrs	hrs	NOUN
dti-1314	119	8	after	after	ADP
dti-1314	119	9	being	be	AUX
dti-1314	119	10	in	in	ADP
dti-1314	119	11	normal	normal	ADJ
dti-1314	119	12	media	medium	NOUN
dti-1314	119	13	cells	cell	NOUN
dti-1314	119	14	were	be	AUX
dti-1314	119	15	harvested	harvest	VERB
dti-1314	119	16	table	table	NOUN
dti-1314	119	17	i.	i.	NOUN
dti-1314	119	18	growth	growth	NOUN
dti-1314	119	19	inhibitory	inhibitory	ADJ
dti-1314	119	20	effect	effect	NOUN
dti-1314	119	21	of	of	ADP
dti-1314	119	22	adi	adi	NOUN
dti-1314	119	23	-	-	PUNCT
dti-1314	119	24	peg20	peg20	PROPN
dti-1314	119	25	.	.	PUNCT
dti-1314	120	1	cell	cell	NOUN
dti-1314	120	2	lines	line	NOUN
dti-1314	120	3	id50(ug	id50(ug	NOUN
dti-1314	120	4	/	/	SYM
dti-1314	120	5	ml	ml	NOUN
dti-1314	120	6	)	)	PUNCT
dti-1314	120	7	arginine	arginine	NOUN
dti-1314	120	8	um	um	INTJ
dti-1314	120	9	citrulline	citrulline	NOUN
dti-1314	120	10	um	um	INTJ
dti-1314	120	11	(	(	PUNCT
dti-1314	120	12	72	72	NUM
dti-1314	120	13	h	h	NOUN
dti-1314	120	14	)	)	PUNCT
dti-1314	120	15	(	(	PUNCT
dti-1314	120	16	72	72	NUM
dti-1314	120	17	h	h	NOUN
dti-1314	120	18	)	)	PUNCT
dti-1314	120	19	a2058	a2058	NUM
dti-1314	120	20	0.088	0.088	NUM
dti-1314	120	21	±	±	NUM
dti-1314	120	22	0.008	0.008	NUM
dti-1314	120	23	23.5	23.5	NUM
dti-1314	120	24	367.5	367.5	NUM
dti-1314	120	25	a375	a375	PROPN
dti-1314	120	26	0.055	0.055	NUM
dti-1314	120	27	±	±	NOUN
dti-1314	120	28	0.001	0.001	NUM
dti-1314	120	29	nd	nd	NUM
dti-1314	120	30	317.5	317.5	NUM
dti-1314	120	31	sk	sk	NOUN
dti-1314	120	32	-	-	PUNCT
dti-1314	120	33	mel-2	mel-2	NUM
dti-1314	120	34	0.07	0.07	NUM
dti-1314	120	35	±	±	NUM
dti-1314	120	36	0.008	0.008	NUM
dti-1314	120	37	12.8	12.8	NUM
dti-1314	120	38	329.2	329.2	NUM
dti-1314	120	39	mel-1220	mel-1220	NOUN
dti-1314	120	40	0.09	0.09	NUM
dti-1314	120	41	±	±	NUM
dti-1314	120	42	0.005	0.005	NUM
dti-1314	120	43	0	0	NUM
dti-1314	120	44	3	3	NUM
dti-1314	120	45	bj-1	bj-1	ADV
dti-1314	120	46	>	>	X
dti-1314	120	47	1	1	NUM
dti-1314	120	48	1.6	1.6	NUM
dti-1314	120	49	404	404	NUM
dti-1314	120	50	nsclcs	nsclcs	NOUN
dti-1314	120	51	*	*	PUNCT
dti-1314	120	52	>	>	PROPN
dti-1314	120	53	1	1	NUM
dti-1314	120	54	20.27	20.27	NUM
dti-1314	120	55	603	603	NUM
dti-1314	120	56	*	*	PUNCT
dti-1314	120	57	rpmi	rpmi	NOUN
dti-1314	120	58	media	medium	NOUN
dti-1314	120	59	(	(	PUNCT
dti-1314	120	60	base	base	NOUN
dti-1314	120	61	line	line	NOUN
dti-1314	120	62	arginine	arginine	NOUN
dti-1314	120	63	:	:	PUNCT
dti-1314	120	64	971um	971um	NOUN
dti-1314	120	65	)	)	PUNCT
dti-1314	120	66	emem	emem	ADJ
dti-1314	120	67	media	medium	NOUN
dti-1314	120	68	(	(	PUNCT
dti-1314	120	69	base	base	NOUN
dti-1314	120	70	line	line	NOUN
dti-1314	120	71	arginine	arginine	NOUN
dti-1314	120	72	:	:	PUNCT
dti-1314	120	73	400um	400um	PROPN
dti-1314	120	74	)	)	PUNCT
dti-1314	120	75	a3	a3	VERB
dti-1314	120	76	75	75	NUM
dti-1314	120	77	s	s	NOUN
dti-1314	120	78	km	km	PROPN
dti-1314	120	79	el	el	PROPN
dti-1314	120	80	-2	-2	PROPN
dti-1314	120	81	a2	a2	PROPN
dti-1314	120	82	05	05	NUM
dti-1314	121	1	8	8	NUM
dti-1314	121	2	m	m	NOUN
dti-1314	121	3	el	el	PROPN
dti-1314	121	4	-1	-1	PROPN
dti-1314	122	1	22	22	NUM
dti-1314	122	2	0	0	NUM
dti-1314	122	3	b	b	NOUN
dti-1314	122	4	j1	j1	PROPN
dti-1314	122	5	ass	ass	NOUN
dti-1314	122	6	actin	actin	NOUN
dti-1314	122	7	figure	figure	NOUN
dti-1314	122	8	2	2	NUM
dti-1314	122	9	.	.	PUNCT
dti-1314	122	10	southernblot	southernblot	ADJ
dti-1314	122	11	analysis	analysis	NOUN
dti-1314	122	12	of	of	ADP
dti-1314	122	13	ass	ass	NOUN
dti-1314	122	14	in	in	ADP
dti-1314	122	15	4	4	NUM
dti-1314	122	16	melanoma	melanoma	NOUN
dti-1314	122	17	cell	cell	NOUN
dti-1314	122	18	lines	line	NOUN
dti-1314	122	19	and	and	CCONJ
dti-1314	122	20	bj-1	bj-1	ADV
dti-1314	122	21	cell	cell	NOUN
dti-1314	122	22	lines	line	NOUN
dti-1314	122	23	.	.	PUNCT
dti-1314	123	1	all	all	DET
dti-1314	123	2	fi	fi	NOUN
dti-1314	123	3	ve	ve	NOUN
dti-1314	123	4	cell	cell	NOUN
dti-1314	123	5	lines	line	NOUN
dti-1314	123	6	show	show	VERB
dti-1314	123	7	similar	similar	ADJ
dti-1314	123	8	levels	level	NOUN
dti-1314	123	9	of	of	ADP
dti-1314	123	10	ass	ass	PROPN
dti-1314	123	11	dna	dna	NOUN
dti-1314	123	12	.	.	PUNCT
dti-1314	124	1	123	123	NUM
dti-1314	124	2	argininosuccinate	argininosuccinate	NOUN
dti-1314	124	3	synthetase	synthetase	NOUN
dti-1314	124	4	in	in	ADP
dti-1314	124	5	melanoma	melanoma	NOUN
dti-1314	124	6	drug	drug	NOUN
dti-1314	124	7	target	target	NOUN
dti-1314	124	8	insights	insight	NOUN
dti-1314	124	9	2007	2007	NUM
dti-1314	124	10	:	:	SYM
dti-1314	124	11	2	2	NUM
dti-1314	124	12	and	and	CCONJ
dti-1314	124	13	assayed	assayed	ADJ
dti-1314	124	14	for	for	ADP
dti-1314	124	15	ass	ass	NOUN
dti-1314	124	16	expression	expression	NOUN
dti-1314	124	17	.	.	PUNCT
dti-1314	125	1	the	the	DET
dti-1314	125	2	results	result	NOUN
dti-1314	125	3	are	be	AUX
dti-1314	125	4	shown	show	VERB
dti-1314	125	5	in	in	ADP
dti-1314	125	6	figure	figure	NOUN
dti-1314	125	7	5	5	NUM
dti-1314	125	8	.	.	PUNCT
dti-1314	126	1	the	the	DET
dti-1314	126	2	three	three	NUM
dti-1314	126	3	type	type	NOUN
dti-1314	126	4	of	of	ADP
dti-1314	126	5	media	medium	NOUN
dti-1314	126	6	yield	yield	VERB
dti-1314	126	7	similar	similar	ADJ
dti-1314	126	8	results	result	NOUN
dti-1314	126	9	.	.	PUNCT
dti-1314	127	1	similar	similar	ADJ
dti-1314	127	2	to	to	ADP
dti-1314	127	3	data	datum	NOUN
dti-1314	127	4	in	in	ADP
dti-1314	127	5	figure	figure	NOUN
dti-1314	127	6	4	4	NUM
dti-1314	127	7	,	,	PUNCT
dti-1314	127	8	a2058	a2058	PROPN
dti-1314	127	9	appears	appear	VERB
dti-1314	127	10	to	to	PART
dti-1314	127	11	have	have	VERB
dti-1314	127	12	highest	high	ADJ
dti-1314	127	13	ass	ass	NOUN
dti-1314	127	14	levels	level	NOUN
dti-1314	127	15	in	in	ADP
dti-1314	127	16	arginine	arginine	NOUN
dti-1314	127	17	free	free	ADJ
dti-1314	127	18	media	medium	NOUN
dti-1314	127	19	followed	follow	VERB
dti-1314	127	20	by	by	ADP
dti-1314	127	21	sk	sk	NOUN
dti-1314	127	22	-	-	PUNCT
dti-1314	127	23	mel-2	mel-2	PUNCT
dti-1314	127	24	and	and	CCONJ
dti-1314	127	25	a375	a375	PROPN
dti-1314	127	26	,	,	PUNCT
dti-1314	127	27	while	while	SCONJ
dti-1314	127	28	mel	mel	PROPN
dti-1314	127	29	1220	1220	NUM
dti-1314	127	30	has	have	VERB
dti-1314	127	31	no	no	DET
dti-1314	127	32	effect	effect	NOUN
dti-1314	127	33	(	(	PUNCT
dti-1314	127	34	data	datum	NOUN
dti-1314	127	35	not	not	PART
dti-1314	127	36	shown	show	VERB
dti-1314	127	37	)	)	PUNCT
dti-1314	127	38	.	.	PUNCT
dti-1314	128	1	thus	thus	ADV
dti-1314	128	2	,	,	PUNCT
dti-1314	128	3	our	our	PRON
dti-1314	128	4	results	result	NOUN
dti-1314	128	5	indicate	indicate	VERB
dti-1314	128	6	that	that	SCONJ
dti-1314	128	7	the	the	DET
dti-1314	128	8	levels	level	NOUN
dti-1314	128	9	of	of	ADP
dti-1314	128	10	arginine	arginine	NOUN
dti-1314	128	11	in	in	ADP
dti-1314	128	12	the	the	DET
dti-1314	128	13	media	medium	NOUN
dti-1314	128	14	regulate	regulate	VERB
dti-1314	128	15	ass	ass	NOUN
dti-1314	128	16	protein	protein	NOUN
dti-1314	128	17	levels	level	NOUN
dti-1314	128	18	,	,	PUNCT
dti-1314	128	19	and	and	CCONJ
dti-1314	128	20	that	that	SCONJ
dti-1314	128	21	the	the	DET
dti-1314	128	22	amount	amount	NOUN
dti-1314	128	23	of	of	ADP
dti-1314	128	24	citrulline	citrulline	NOUN
dti-1314	128	25	did	do	AUX
dti-1314	128	26	not	not	PART
dti-1314	128	27	have	have	VERB
dti-1314	128	28	any	any	DET
dti-1314	128	29	effect	effect	NOUN
dti-1314	128	30	.	.	PUNCT
dti-1314	129	1	interestingly	interestingly	ADV
dti-1314	129	2	,	,	PUNCT
dti-1314	129	3	ass	ass	NOUN
dti-1314	129	4	gene	gene	NOUN
dti-1314	129	5	expression	expression	NOUN
dti-1314	129	6	can	can	AUX
dti-1314	129	7	not	not	PART
dti-1314	129	8	be	be	AUX
dti-1314	129	9	detected	detect	VERB
dti-1314	129	10	by	by	ADP
dti-1314	129	11	northernblot	northernblot	ADJ
dti-1314	129	12	analysis	analysis	NOUN
dti-1314	129	13	(	(	PUNCT
dti-1314	129	14	fig	fig	NOUN
dti-1314	129	15	.	.	PUNCT
dti-1314	130	1	8)	8)	NUM
dti-1314	130	2	,	,	PUNCT
dti-1314	130	3	but	but	CCONJ
dti-1314	130	4	may	may	AUX
dti-1314	130	5	be	be	AUX
dti-1314	130	6	slightly	slightly	ADV
dti-1314	130	7	increased	increase	VERB
dti-1314	130	8	by	by	ADP
dti-1314	130	9	rt	rt	PROPN
dti-1314	130	10	-	-	PUNCT
dti-1314	130	11	pcr	pcr	PROPN
dti-1314	130	12	(	(	PUNCT
dti-1314	130	13	data	datum	NOUN
dti-1314	130	14	not	not	PART
dti-1314	130	15	shown	show	VERB
dti-1314	130	16	)	)	PUNCT
dti-1314	130	17	.	.	PUNCT
dti-1314	131	1	thus	thus	ADV
dti-1314	131	2	,	,	PUNCT
dti-1314	131	3	it	it	PRON
dti-1314	131	4	appears	appear	VERB
dti-1314	131	5	that	that	SCONJ
dti-1314	131	6	increased	increase	VERB
dti-1314	131	7	translation	translation	NOUN
dti-1314	131	8	of	of	ADP
dti-1314	131	9	ass	ass	NOUN
dti-1314	131	10	proceeds	proceed	VERB
dti-1314	131	11	transcription	transcription	NOUN
dti-1314	131	12	.	.	PUNCT
dti-1314	132	1	arginine	arginine	NOUN
dti-1314	132	2	deprivation	deprivation	NOUN
dti-1314	132	3	does	do	AUX
dti-1314	132	4	not	not	PART
dti-1314	132	5	induce	induce	VERB
dti-1314	132	6	ass	ass	NOUN
dti-1314	132	7	expression	expression	NOUN
dti-1314	132	8	in	in	ADP
dti-1314	132	9	nsclc	nsclc	NOUN
dti-1314	132	10	we	we	PRON
dti-1314	132	11	further	far	ADV
dti-1314	132	12	investigated	investigate	VERB
dti-1314	132	13	whether	whether	SCONJ
dti-1314	132	14	arginine	arginine	NOUN
dti-1314	132	15	deprivation	deprivation	NOUN
dti-1314	132	16	also	also	ADV
dti-1314	132	17	induced	induce	VERB
dti-1314	132	18	ass	ass	NOUN
dti-1314	132	19	expression	expression	NOUN
dti-1314	132	20	in	in	ADP
dti-1314	132	21	tumor	tumor	NOUN
dti-1314	132	22	cell	cell	NOUN
dti-1314	132	23	lines	line	NOUN
dti-1314	132	24	which	which	PRON
dti-1314	132	25	constitutively	constitutively	ADV
dti-1314	132	26	express	express	VERB
dti-1314	132	27	ass	ass	NOUN
dti-1314	132	28	.	.	PUNCT
dti-1314	133	1	we	we	PRON
dti-1314	133	2	have	have	AUX
dti-1314	133	3	chosen	choose	VERB
dti-1314	133	4	nsclcs	nsclcs	NOUN
dti-1314	133	5	which	which	PRON
dti-1314	133	6	was	be	AUX
dti-1314	133	7	established	establish	VERB
dti-1314	133	8	from	from	ADP
dti-1314	133	9	metastatic	metastatic	ADJ
dti-1314	133	10	adenocarcinoma	adenocarcinoma	NOUN
dti-1314	133	11	of	of	ADP
dti-1314	133	12	the	the	DET
dti-1314	133	13	lung	lung	NOUN
dti-1314	133	14	to	to	ADP
dti-1314	133	15	the	the	DET
dti-1314	133	16	brain	brain	NOUN
dti-1314	133	17	.	.	PUNCT
dti-1314	134	1	this	this	DET
dti-1314	134	2	cell	cell	NOUN
dti-1314	134	3	line	line	NOUN
dti-1314	134	4	expresses	express	VERB
dti-1314	134	5	ass	ass	NOUN
dti-1314	134	6	and	and	CCONJ
dti-1314	134	7	is	be	AUX
dti-1314	134	8	not	not	PART
dti-1314	134	9	sensitive	sensitive	ADJ
dti-1314	134	10	to	to	ADP
dti-1314	134	11	adi	adi	NOUN
dti-1314	134	12	-	-	PUNCT
dti-1314	134	13	peg20	peg20	NOUN
dti-1314	134	14	.	.	PUNCT
dti-1314	135	1	cells	cell	NOUN
dti-1314	135	2	were	be	AUX
dti-1314	135	3	seeded	seed	VERB
dti-1314	135	4	in	in	ADP
dti-1314	135	5	arginine	arginine	NOUN
dti-1314	135	6	free	free	ADJ
dti-1314	135	7	media	medium	NOUN
dti-1314	135	8	with	with	ADP
dti-1314	135	9	citrulline	citrulline	NOUN
dti-1314	135	10	supplement	supplement	NOUN
dti-1314	135	11	or	or	CCONJ
dti-1314	135	12	adi	adi	NOUN
dti-1314	135	13	-	-	PUNCT
dti-1314	135	14	peg20	peg20	PROPN
dti-1314	135	15	treated	treat	VERB
dti-1314	135	16	media	medium	NOUN
dti-1314	135	17	to	to	PART
dti-1314	135	18	degrade	degrade	VERB
dti-1314	135	19	all	all	DET
dti-1314	135	20	arginine	arginine	NOUN
dti-1314	135	21	for	for	ADP
dti-1314	135	22	3	3	NUM
dti-1314	135	23	day	day	NOUN
dti-1314	135	24	and	and	CCONJ
dti-1314	135	25	assay	assay	VERB
dti-1314	135	26	for	for	ADP
dti-1314	135	27	ass	ass	NOUN
dti-1314	135	28	expression	expression	NOUN
dti-1314	135	29	by	by	ADP
dti-1314	135	30	westernblot	westernblot	NOUN
dti-1314	135	31	.	.	PUNCT
dti-1314	136	1	the	the	DET
dti-1314	136	2	results	result	NOUN
dti-1314	136	3	are	be	AUX
dti-1314	136	4	shown	show	VERB
dti-1314	136	5	in	in	ADP
dti-1314	136	6	figure	figure	NOUN
dti-1314	136	7	6	6	NUM
dti-1314	136	8	.	.	PUNCT
dti-1314	137	1	ass	ass	NOUN
dti-1314	137	2	expression	expression	NOUN
dti-1314	137	3	is	be	AUX
dti-1314	137	4	similar	similar	ADJ
dti-1314	137	5	in	in	ADP
dti-1314	137	6	normal	normal	ADJ
dti-1314	137	7	media	medium	NOUN
dti-1314	137	8	or	or	CCONJ
dti-1314	137	9	arginine	arginine	NOUN
dti-1314	137	10	depleted	depleted	ADJ
dti-1314	137	11	media	medium	NOUN
dti-1314	137	12	.	.	PUNCT
dti-1314	138	1	thus	thus	ADV
dti-1314	138	2	,	,	PUNCT
dti-1314	138	3	it	it	PRON
dti-1314	138	4	appears	appear	VERB
dti-1314	138	5	that	that	SCONJ
dti-1314	138	6	arginine	arginine	NOUN
dti-1314	138	7	deprivation	deprivation	NOUN
dti-1314	138	8	does	do	AUX
dti-1314	138	9	not	not	PART
dti-1314	138	10	have	have	VERB
dti-1314	138	11	effect	effect	NOUN
dti-1314	138	12	on	on	ADP
dti-1314	138	13	ass	ass	NOUN
dti-1314	138	14	expression	expression	NOUN
dti-1314	138	15	in	in	ADP
dti-1314	138	16	tumor	tumor	NOUN
dti-1314	138	17	cell	cell	NOUN
dti-1314	138	18	lines	line	NOUN
dti-1314	138	19	which	which	PRON
dti-1314	138	20	constitutively	constitutively	ADV
dti-1314	138	21	express	express	VERB
dti-1314	138	22	high	high	ADJ
dti-1314	138	23	levels	level	NOUN
dti-1314	138	24	of	of	ADP
dti-1314	138	25	ass	ass	NOUN
dti-1314	138	26	.	.	PUNCT
dti-1314	139	1	ass	ass	NOUN
dti-1314	139	2	gene	gene	NOUN
dti-1314	139	3	transfection	transfection	NOUN
dti-1314	139	4	results	result	VERB
dti-1314	139	5	in	in	ADP
dti-1314	139	6	resistance	resistance	NOUN
dti-1314	139	7	to	to	ADP
dti-1314	139	8	adi	adi	PROPN
dti-1314	139	9	we	we	PRON
dti-1314	139	10	have	have	AUX
dti-1314	139	11	transfected	transfecte	VERB
dti-1314	139	12	ass	ass	NOUN
dti-1314	139	13	cdna	cdna	PROPN
dti-1314	139	14	into	into	ADP
dti-1314	139	15	a375	a375	PROPN
dti-1314	139	16	,	,	PUNCT
dti-1314	139	17	and	and	CCONJ
dti-1314	139	18	a2058	a2058	NUM
dti-1314	139	19	,	,	PUNCT
dti-1314	139	20	and	and	CCONJ
dti-1314	139	21	then	then	ADV
dti-1314	139	22	assay	assay	VERB
dti-1314	139	23	for	for	ADP
dti-1314	139	24	growth	growth	NOUN
dti-1314	139	25	inhibitory	inhibitory	ADJ
dti-1314	139	26	effect	effect	NOUN
dti-1314	139	27	of	of	ADP
dti-1314	139	28	adi	adi	NOUN
dti-1314	139	29	-	-	PUNCT
dti-1314	139	30	peg20	peg20	NOUN
dti-1314	139	31	.	.	PUNCT
dti-1314	140	1	we	we	PRON
dti-1314	140	2	are	be	AUX
dti-1314	140	3	able	able	ADJ
dti-1314	140	4	to	to	PART
dti-1314	140	5	obtain	obtain	VERB
dti-1314	140	6	only	only	ADV
dti-1314	140	7	2	2	NUM
dti-1314	140	8	fold	fold	NOUN
dti-1314	140	9	increase	increase	NOUN
dti-1314	140	10	in	in	ADP
dti-1314	140	11	ass	ass	NOUN
dti-1314	140	12	expression	expression	NOUN
dti-1314	140	13	as	as	SCONJ
dti-1314	140	14	shown	show	VERB
dti-1314	140	15	by	by	ADP
dti-1314	140	16	rt	rt	PROPN
dti-1314	140	17	-	-	PUNCT
dti-1314	140	18	pcr	pcr	PROPN
dti-1314	140	19	and	and	CCONJ
dti-1314	140	20	westernblot	westernblot	NOUN
dti-1314	140	21	(	(	PUNCT
dti-1314	140	22	fig	fig	NOUN
dti-1314	140	23	.	.	PUNCT
dti-1314	141	1	7a	7a	NUM
dti-1314	141	2	&	&	CCONJ
dti-1314	141	3	7b	7b	NUM
dti-1314	141	4	)	)	PUNCT
dti-1314	141	5	.	.	PUNCT
dti-1314	142	1	the	the	DET
dti-1314	142	2	id50	id50	PROPN
dti-1314	142	3	of	of	ADP
dti-1314	142	4	these	these	DET
dti-1314	142	5	a	a	DET
dti-1314	142	6	b	b	NOUN
dti-1314	142	7	figure	figure	NOUN
dti-1314	142	8	3a	3a	NUM
dti-1314	142	9	.	.	PUNCT
dti-1314	143	1	in	in	ADP
dti-1314	143	2	situ	situ	ADJ
dti-1314	143	3	end	end	NOUN
dti-1314	143	4	labeling	labeling	NOUN
dti-1314	143	5	apoptosis	apoptosis	NOUN
dti-1314	143	6	assay	assay	NOUN
dti-1314	143	7	in	in	ADP
dti-1314	143	8	a375	a375	PROPN
dti-1314	143	9	cell	cell	NOUN
dti-1314	143	10	line	line	NOUN
dti-1314	143	11	.	.	PUNCT
dti-1314	144	1	a	a	DET
dti-1314	144	2	:	:	PUNCT
dti-1314	144	3	control	control	NOUN
dti-1314	144	4	.	.	PUNCT
dti-1314	145	1	b	b	X
dti-1314	145	2	:	:	PUNCT
dti-1314	145	3	after	after	ADP
dti-1314	145	4	exposure	exposure	NOUN
dti-1314	145	5	to	to	ADP
dti-1314	145	6	0.08	0.08	NUM
dti-1314	145	7	ug	ug	ADP
dti-1314	145	8	/	/	SYM
dti-1314	145	9	ml	ml	NOUN
dti-1314	145	10	for	for	ADP
dti-1314	145	11	72	72	NUM
dti-1314	145	12	hr	hr	NOUN
dti-1314	145	13	.	.	PUNCT
dti-1314	145	14	treated	treat	VERB
dti-1314	145	15	cells	cell	NOUN
dti-1314	145	16	undergo	undergo	VERB
dti-1314	145	17	apopotosis	apopotosis	NOUN
dti-1314	145	18	shown	show	VERB
dti-1314	145	19	brown	brown	ADJ
dti-1314	145	20	staining	stain	VERB
dti-1314	145	21	in	in	ADP
dti-1314	145	22	the	the	DET
dti-1314	145	23	nuclei	nucleus	NOUN
dti-1314	145	24	.	.	PUNCT
dti-1314	146	1	116kd	116kd	PROPN
dti-1314	146	2	89kd	89kd	ADJ
dti-1314	146	3	actin	actin	NOUN
dti-1314	146	4	+	+	X
dti-1314	147	1	+	+	PUNCT
dti-1314	147	2	+	+	CCONJ
dti-1314	147	3	+	+	ADJ
dti-1314	147	4	adi	adi	PROPN
dti-1314	147	5	a375	a375	PROPN
dti-1314	147	6	sk	sk	PROPN
dti-1314	147	7	-	-	PUNCT
dti-1314	147	8	mel-2	mel-2	ADJ
dti-1314	147	9	a2058	a2058	PROPN
dti-1314	147	10	mel-1220	mel-1220	ADJ
dti-1314	147	11	parp	parp	ADJ
dti-1314	147	12	figure	figure	NOUN
dti-1314	147	13	3b	3b	NUM
dti-1314	147	14	.	.	PUNCT
dti-1314	148	1	apoptosis	apoptosis	NOUN
dti-1314	148	2	as	as	SCONJ
dti-1314	148	3	detected	detect	VERB
dti-1314	148	4	by	by	ADP
dti-1314	148	5	parp	parp	ADJ
dti-1314	148	6	cleavage	cleavage	NOUN
dti-1314	148	7	in	in	ADP
dti-1314	148	8	4	4	NUM
dti-1314	148	9	melanoma	melanoma	NOUN
dti-1314	148	10	cell	cell	NOUN
dti-1314	148	11	lines	line	NOUN
dti-1314	148	12	(	(	PUNCT
dti-1314	148	13	a375	a375	PROPN
dti-1314	148	14	,	,	PUNCT
dti-1314	148	15	sk	sk	NOUN
dti-1314	148	16	-	-	PUNCT
dti-1314	148	17	mel-2	mel-2	NOUN
dti-1314	148	18	,	,	PUNCT
dti-1314	148	19	a2058	a2058	NUM
dti-1314	148	20	and	and	CCONJ
dti-1314	148	21	mel-1220	mel-1220	ADJ
dti-1314	148	22	)	)	PUNCT
dti-1314	148	23	.	.	PUNCT
dti-1314	149	1	untreated	untreated	ADJ
dti-1314	149	2	cell	cell	NOUN
dti-1314	149	3	showed	show	VERB
dti-1314	149	4	uncleaved	uncleaved	ADJ
dti-1314	149	5	parp	parp	NOUN
dti-1314	149	6	at	at	ADP
dti-1314	149	7	116	116	NUM
dti-1314	149	8	kd	kd	PROPN
dti-1314	149	9	whereas	whereas	SCONJ
dti-1314	149	10	treated	treat	VERB
dti-1314	149	11	cells	cell	NOUN
dti-1314	149	12	showed	show	VERB
dti-1314	149	13	cleaved	cleaved	ADJ
dti-1314	149	14	parp	parp	NOUN
dti-1314	149	15	seen	see	VERB
dti-1314	149	16	at	at	ADP
dti-1314	149	17	89	89	NUM
dti-1314	149	18	kd	kd	PROPN
dti-1314	149	19	.	.	PROPN
dti-1314	149	20	124	124	NUM
dti-1314	149	21	savaraj	savaraj	VERB
dti-1314	149	22	et	et	PROPN
dti-1314	149	23	al	al	PROPN
dti-1314	149	24	drug	drug	PROPN
dti-1314	149	25	target	target	NOUN
dti-1314	149	26	insights	insight	NOUN
dti-1314	149	27	2007	2007	NUM
dti-1314	149	28	:	:	PUNCT
dti-1314	149	29	2	2	NUM
dti-1314	149	30	generation	generation	NOUN
dti-1314	149	31	of	of	ADP
dti-1314	149	32	adi	adi	NOUN
dti-1314	149	33	-	-	PUNCT
dti-1314	149	34	peg20	peg20	ADJ
dti-1314	149	35	resistant	resistant	ADJ
dti-1314	149	36	cell	cell	NOUN
dti-1314	149	37	line	line	NOUN
dti-1314	149	38	since	since	SCONJ
dti-1314	149	39	we	we	PRON
dti-1314	149	40	were	be	AUX
dti-1314	149	41	unable	unable	ADJ
dti-1314	149	42	to	to	PART
dti-1314	149	43	generate	generate	VERB
dti-1314	149	44	a	a	DET
dti-1314	149	45	stable	stable	ADJ
dti-1314	149	46	ass	ass	NOUN
dti-1314	149	47	transfected	transfecte	VERB
dti-1314	149	48	cell	cell	NOUN
dti-1314	149	49	line	line	NOUN
dti-1314	149	50	with	with	ADP
dti-1314	149	51	high	high	ADJ
dti-1314	149	52	levels	level	NOUN
dti-1314	149	53	of	of	ADP
dti-1314	149	54	ass	ass	NOUN
dti-1314	149	55	expression	expression	NOUN
dti-1314	149	56	,	,	PUNCT
dti-1314	149	57	we	we	PRON
dti-1314	149	58	have	have	AUX
dti-1314	149	59	exposed	expose	VERB
dti-1314	149	60	a2058	a2058	NUM
dti-1314	149	61	cell	cell	NOUN
dti-1314	149	62	lines	line	NOUN
dti-1314	149	63	to	to	ADP
dti-1314	149	64	adi	adi	NOUN
dti-1314	149	65	-	-	PUNCT
dti-1314	149	66	peg20	peg20	PROPN
dti-1314	149	67	at	at	ADP
dti-1314	149	68	0.05	0.05	NUM
dti-1314	149	69	ug	ug	ADP
dti-1314	149	70	/	/	SYM
dti-1314	149	71	ml	ml	X
dti-1314	149	72	for	for	ADP
dti-1314	149	73	5	5	NUM
dti-1314	149	74	days	day	NOUN
dti-1314	149	75	with	with	ADP
dti-1314	149	76	2	2	NUM
dti-1314	149	77	days	day	NOUN
dti-1314	149	78	off	off	ADP
dti-1314	149	79	×	×	NOUN
dti-1314	149	80	6	6	NUM
dti-1314	149	81	weeks	week	NOUN
dti-1314	149	82	.	.	PUNCT
dti-1314	150	1	we	we	PRON
dti-1314	150	2	were	be	AUX
dti-1314	150	3	able	able	ADJ
dti-1314	150	4	to	to	PART
dti-1314	150	5	establish	establish	VERB
dti-1314	150	6	a2058r	a2058r	PROPN
dti-1314	150	7	with	with	ADP
dti-1314	150	8	high	high	ADJ
dti-1314	150	9	levels	level	NOUN
dti-1314	150	10	of	of	ADP
dti-1314	150	11	ass	ass	NOUN
dti-1314	150	12	expression	expression	NOUN
dti-1314	150	13	by	by	ADP
dti-1314	150	14	northernblot	northernblot	NOUN
dti-1314	150	15	(	(	PUNCT
dti-1314	150	16	fig	fig	NOUN
dti-1314	150	17	.	.	PUNCT
dti-1314	151	1	8a	8a	NUM
dti-1314	151	2	)	)	PUNCT
dti-1314	151	3	and	and	CCONJ
dti-1314	151	4	by	by	ADP
dti-1314	151	5	westernblot	westernblot	NOUN
dti-1314	151	6	analysis	analysis	NOUN
dti-1314	151	7	(	(	PUNCT
dti-1314	151	8	fig	fig	NOUN
dti-1314	151	9	.	.	PUNCT
dti-1314	152	1	8b	8b	NUM
dti-1314	152	2	)	)	PUNCT
dti-1314	152	3	.	.	PUNCT
dti-1314	153	1	this	this	DET
dti-1314	153	2	cell	cell	NOUN
dti-1314	153	3	line	line	NOUN
dti-1314	153	4	is	be	AUX
dti-1314	153	5	resistant	resistant	ADJ
dti-1314	153	6	to	to	ADP
dti-1314	153	7	adi	adi	NOUN
dti-1314	153	8	-	-	PUNCT
dti-1314	153	9	peg20	peg20	NOUN
dti-1314	153	10	with	with	ADP
dti-1314	153	11	id50	id50	PROPN
dti-1314	153	12	>	>	PROPN
dti-1314	153	13	1	1	NUM
dti-1314	153	14	ug	ug	ADP
dti-1314	153	15	/	/	SYM
dti-1314	153	16	ml	ml	NOUN
dti-1314	153	17	.	.	PUNCT
dti-1314	154	1	interestingly	interestingly	ADV
dti-1314	154	2	,	,	PUNCT
dti-1314	154	3	the	the	DET
dti-1314	154	4	levels	level	NOUN
dti-1314	154	5	of	of	ADP
dti-1314	154	6	ass	ass	NOUN
dti-1314	154	7	protein	protein	NOUN
dti-1314	154	8	also	also	ADV
dti-1314	154	9	are	be	AUX
dti-1314	154	10	not	not	PART
dti-1314	154	11	affected	affect	VERB
dti-1314	154	12	by	by	ADP
dti-1314	154	13	arginine	arginine	NOUN
dti-1314	154	14	deprivation	deprivation	NOUN
dti-1314	154	15	(	(	PUNCT
dti-1314	154	16	data	datum	NOUN
dti-1314	154	17	not	not	PART
dti-1314	154	18	shown	show	VERB
dti-1314	154	19	)	)	PUNCT
dti-1314	154	20	.	.	PUNCT
dti-1314	155	1	discussion	discussion	NOUN
dti-1314	155	2	it	it	PRON
dti-1314	155	3	has	have	AUX
dti-1314	155	4	been	be	AUX
dti-1314	155	5	reported	report	VERB
dti-1314	155	6	that	that	SCONJ
dti-1314	155	7	melanoma	melanoma	NOUN
dti-1314	155	8	cell	cell	NOUN
dti-1314	155	9	lines	line	NOUN
dti-1314	155	10	as	as	ADV
dti-1314	155	11	well	well	ADV
dti-1314	155	12	as	as	ADP
dti-1314	155	13	tumor	tumor	NOUN
dti-1314	155	14	samples	sample	NOUN
dti-1314	155	15	do	do	AUX
dti-1314	155	16	not	not	PART
dti-1314	155	17	express	express	VERB
dti-1314	155	18	ass	ass	NOUN
dti-1314	155	19	and	and	CCONJ
dti-1314	155	20	thus	thus	ADV
dti-1314	155	21	are	be	AUX
dti-1314	155	22	auxotrophic	auxotrophic	ADJ
dti-1314	155	23	for	for	ADP
dti-1314	155	24	arginine	arginine	NOUN
dti-1314	155	25	.	.	PUNCT
dti-1314	156	1	arginine	arginine	NOUN
dti-1314	156	2	deprivation	deprivation	NOUN
dti-1314	156	3	using	use	VERB
dti-1314	156	4	arginine	arginine	NOUN
dti-1314	156	5	deiminase	deiminase	NOUN
dti-1314	156	6	or	or	CCONJ
dti-1314	156	7	arginase	arginase	NOUN
dti-1314	156	8	has	have	VERB
dti-1314	156	9	ass	ass	PROPN
dti-1314	156	10	actin	actin	NOUN
dti-1314	156	11	ass	ass	NOUN
dti-1314	156	12	actin	actin	NOUN
dti-1314	156	13	ass	ass	NOUN
dti-1314	156	14	actin	actin	NOUN
dti-1314	156	15	a375	a375	PROPN
dti-1314	156	16	sk	sk	PROPN
dti-1314	156	17	-	-	PUNCT
dti-1314	156	18	mel-2	mel-2	NUM
dti-1314	156	19	a2058	a2058	NUM
dti-1314	156	20	1	1	NUM
dti-1314	156	21	2	2	NUM
dti-1314	156	22	3	3	NUM
dti-1314	156	23	4	4	NUM
dti-1314	156	24	5	5	NUM
dti-1314	156	25	6	6	NUM
dti-1314	156	26	7	7	NUM
dti-1314	156	27	figure	figure	NOUN
dti-1314	156	28	5	5	NUM
dti-1314	156	29	.	.	PUNCT
dti-1314	156	30	immunoblot	immunoblot	NOUN
dti-1314	156	31	of	of	ADP
dti-1314	156	32	ass	ass	NOUN
dti-1314	156	33	protein	protein	NOUN
dti-1314	156	34	in	in	ADP
dti-1314	156	35	3	3	NUM
dti-1314	156	36	melanoma	melanoma	NOUN
dti-1314	156	37	cell	cell	NOUN
dti-1314	156	38	lines	line	NOUN
dti-1314	156	39	(	(	PUNCT
dti-1314	156	40	a375	a375	PROPN
dti-1314	156	41	,	,	PUNCT
dti-1314	156	42	sk	sk	NOUN
dti-1314	156	43	-	-	PUNCT
dti-1314	156	44	mel-2	mel-2	NOUN
dti-1314	156	45	,	,	PUNCT
dti-1314	156	46	a2058	a2058	NUM
dti-1314	156	47	)	)	PUNCT
dti-1314	156	48	before	before	ADP
dti-1314	156	49	and	and	CCONJ
dti-1314	156	50	after	after	ADP
dti-1314	156	51	exposure	exposure	NOUN
dti-1314	156	52	arginine	arginine	NOUN
dti-1314	156	53	free	free	ADJ
dti-1314	156	54	media	medium	NOUN
dti-1314	156	55	supplemented	supplement	VERB
dti-1314	156	56	with	with	ADP
dti-1314	156	57	citrulline	citrulline	NOUN
dti-1314	156	58	and	and	CCONJ
dti-1314	156	59	nh4cl	nh4cl	PROPN
dti-1314	156	60	for	for	ADP
dti-1314	156	61	24	24	NUM
dti-1314	156	62	,	,	PUNCT
dti-1314	156	63	48	48	NUM
dti-1314	156	64	and	and	CCONJ
dti-1314	156	65	72	72	NUM
dti-1314	156	66	hrs	hrs	NOUN
dti-1314	156	67	.	.	PUNCT
dti-1314	157	1	afterward	afterward	ADV
dti-1314	157	2	,	,	PUNCT
dti-1314	157	3	cells	cell	NOUN
dti-1314	157	4	were	be	AUX
dti-1314	157	5	washed	wash	VERB
dti-1314	157	6	,	,	PUNCT
dti-1314	157	7	and	and	CCONJ
dti-1314	157	8	replenished	replenish	VERB
dti-1314	157	9	with	with	ADP
dti-1314	157	10	normal	normal	ADJ
dti-1314	157	11	emem	emem	ADJ
dti-1314	157	12	media	medium	NOUN
dti-1314	157	13	for	for	ADP
dti-1314	157	14	24	24	NUM
dti-1314	157	15	,	,	PUNCT
dti-1314	157	16	48	48	NUM
dti-1314	157	17	and	and	CCONJ
dti-1314	157	18	72hrs	72hrs	ADJ
dti-1314	157	19	.	.	PUNCT
dti-1314	158	1	lane	lane	PROPN
dti-1314	158	2	1	1	NUM
dti-1314	158	3	:	:	PUNCT
dti-1314	158	4	control	control	NOUN
dti-1314	158	5	.	.	PUNCT
dti-1314	159	1	lane	lane	NOUN
dti-1314	159	2	2	2	NUM
dti-1314	159	3	:	:	SYM
dti-1314	159	4	24	24	NUM
dti-1314	159	5	hrs	hrs	NOUN
dti-1314	159	6	on	on	ADP
dti-1314	159	7	arginine	arginine	NOUN
dti-1314	159	8	free	free	ADJ
dti-1314	159	9	media	medium	NOUN
dti-1314	159	10	lane	lane	NOUN
dti-1314	159	11	3	3	NUM
dti-1314	159	12	:	:	SYM
dti-1314	159	13	48hrs	48hrs	NOUN
dti-1314	159	14	on	on	ADP
dti-1314	159	15	arginine	arginine	NOUN
dti-1314	159	16	free	free	ADJ
dti-1314	159	17	media	medium	NOUN
dti-1314	159	18	lane	lane	NOUN
dti-1314	159	19	4	4	NUM
dti-1314	159	20	:	:	SYM
dti-1314	159	21	72	72	NUM
dti-1314	159	22	hrs	hrs	NOUN
dti-1314	159	23	in	in	ADP
dti-1314	159	24	arginine	arginine	NOUN
dti-1314	159	25	free	free	ADJ
dti-1314	159	26	media	medium	NOUN
dti-1314	159	27	lane	lane	NOUN
dti-1314	159	28	5	5	NUM
dti-1314	159	29	:	:	PUNCT
dti-1314	159	30	removal	removal	NOUN
dti-1314	159	31	of	of	ADP
dti-1314	159	32	arginine	arginine	NOUN
dti-1314	159	33	free	free	ADJ
dti-1314	159	34	media	medium	NOUN
dti-1314	159	35	and	and	CCONJ
dti-1314	159	36	changed	change	VERB
dti-1314	159	37	to	to	ADP
dti-1314	159	38	normal	normal	ADJ
dti-1314	159	39	emem	emem	ADJ
dti-1314	159	40	media	medium	NOUN
dti-1314	159	41	for	for	ADP
dti-1314	159	42	24	24	NUM
dti-1314	159	43	hrs	hrs	NOUN
dti-1314	159	44	.	.	PUNCT
dti-1314	160	1	lane	lane	NOUN
dti-1314	160	2	6	6	NUM
dti-1314	160	3	:	:	SYM
dti-1314	160	4	48	48	NUM
dti-1314	160	5	hrs	hrs	NOUN
dti-1314	160	6	in	in	ADP
dti-1314	160	7	normal	normal	ADJ
dti-1314	160	8	media	medium	NOUN
dti-1314	160	9	.	.	PUNCT
dti-1314	161	1	lane	lane	NOUN
dti-1314	161	2	7	7	NUM
dti-1314	161	3	:	:	SYM
dti-1314	161	4	72	72	NUM
dti-1314	161	5	hrs	hrs	NOUN
dti-1314	161	6	in	in	ADP
dti-1314	161	7	normal	normal	ADJ
dti-1314	161	8	media	medium	NOUN
dti-1314	161	9	.	.	PUNCT
dti-1314	162	1	similar	similar	ADJ
dti-1314	162	2	results	result	NOUN
dti-1314	162	3	were	be	AUX
dti-1314	162	4	obtained	obtain	VERB
dti-1314	162	5	with	with	ADP
dti-1314	162	6	arginine	arginine	NOUN
dti-1314	162	7	free	free	ADJ
dti-1314	162	8	media	medium	NOUN
dti-1314	162	9	with	with	ADP
dti-1314	162	10	no	no	DET
dti-1314	162	11	citrulline	citrulline	NOUN
dti-1314	162	12	supplement	supplement	NOUN
dti-1314	162	13	and	and	CCONJ
dti-1314	162	14	adi	adi	NOUN
dti-1314	162	15	-	-	PUNCT
dti-1314	162	16	peg20	peg20	PROPN
dti-1314	162	17	treated	treat	VERB
dti-1314	162	18	media	medium	NOUN
dti-1314	162	19	.	.	PUNCT
dti-1314	163	1	ass	ass	NOUN
dti-1314	163	2	actin	actin	NOUN
dti-1314	163	3	1	1	NUM
dti-1314	163	4	2	2	NUM
dti-1314	163	5	3	3	NUM
dti-1314	163	6	nsclcs	nsclcs	NOUN
dti-1314	163	7	figure	figure	NOUN
dti-1314	163	8	6	6	NUM
dti-1314	163	9	.	.	PUNCT
dti-1314	163	10	immunoblot	immunoblot	NOUN
dti-1314	163	11	of	of	ADP
dti-1314	163	12	ass	ass	NOUN
dti-1314	163	13	in	in	ADP
dti-1314	163	14	nsclcs	nsclcs	NOUN
dti-1314	163	15	:	:	PUNCT
dti-1314	163	16	lane	lane	NOUN
dti-1314	163	17	1	1	NUM
dti-1314	163	18	:	:	PUNCT
dti-1314	163	19	control	control	NOUN
dti-1314	163	20	(	(	PUNCT
dti-1314	163	21	normal	normal	ADJ
dti-1314	163	22	media	medium	NOUN
dti-1314	163	23	)	)	PUNCT
dti-1314	163	24	.	.	PUNCT
dti-1314	164	1	lane	lane	NOUN
dti-1314	164	2	2	2	NUM
dti-1314	164	3	:	:	PUNCT
dti-1314	164	4	adi	adi	NOUN
dti-1314	164	5	-	-	PUNCT
dti-1314	164	6	peg20	peg20	PROPN
dti-1314	164	7	treated	treat	VERB
dti-1314	164	8	media	medium	NOUN
dti-1314	164	9	for	for	ADP
dti-1314	164	10	72	72	NUM
dti-1314	164	11	hr	hr	NOUN
dti-1314	164	12	.	.	PUNCT
dti-1314	165	1	lane	lane	PROPN
dti-1314	165	2	3	3	NUM
dti-1314	165	3	:	:	PUNCT
dti-1314	165	4	after	after	ADP
dti-1314	165	5	exposure	exposure	NOUN
dti-1314	165	6	to	to	AUX
dti-1314	165	7	arginine	arginine	VERB
dti-1314	165	8	free	free	ADJ
dti-1314	165	9	media	medium	NOUN
dti-1314	165	10	with	with	ADP
dti-1314	165	11	citrulline	citrulline	NOUN
dti-1314	165	12	and	and	CCONJ
dti-1314	165	13	nh4cl	nh4cl	NOUN
dti-1314	165	14	supplement	supplement	NOUN
dti-1314	165	15	for	for	ADP
dti-1314	165	16	72	72	NUM
dti-1314	165	17	hrs	hrs	NOUN
dti-1314	165	18	.	.	PUNCT
dti-1314	166	1	transfectants	transfectant	NOUN
dti-1314	166	2	were	be	AUX
dti-1314	166	3	0.1	0.1	NUM
dti-1314	166	4	±	±	NUM
dti-1314	166	5	0.05	0.05	NUM
dti-1314	166	6	ug	ug	ADP
dti-1314	166	7	/	/	SYM
dti-1314	166	8	ml	ml	NOUN
dti-1314	166	9	for	for	ADP
dti-1314	166	10	a375	a375	PROPN
dti-1314	166	11	,	,	PUNCT
dti-1314	166	12	and	and	CCONJ
dti-1314	166	13	0.2	0.2	NUM
dti-1314	166	14	±	±	NUM
dti-1314	166	15	0.05	0.05	NUM
dti-1314	166	16	ug	ug	ADP
dti-1314	166	17	/	/	SYM
dti-1314	166	18	ml	ml	NOUN
dti-1314	166	19	for	for	ADP
dti-1314	166	20	a2058	a2058	PROPN
dti-1314	166	21	,	,	PUNCT
dti-1314	166	22	respectively	respectively	ADV
dti-1314	166	23	.	.	PUNCT
dti-1314	167	1	although	although	SCONJ
dti-1314	167	2	we	we	PRON
dti-1314	167	3	are	be	AUX
dti-1314	167	4	unable	unable	ADJ
dti-1314	167	5	to	to	PART
dti-1314	167	6	yield	yield	VERB
dti-1314	167	7	high	high	ADJ
dti-1314	167	8	levels	level	NOUN
dti-1314	167	9	of	of	ADP
dti-1314	167	10	ass	ass	NOUN
dti-1314	167	11	expression	expression	NOUN
dti-1314	167	12	in	in	ADP
dti-1314	167	13	these	these	DET
dti-1314	167	14	transfectants	transfectant	NOUN
dti-1314	167	15	,	,	PUNCT
dti-1314	167	16	this	this	DET
dti-1314	167	17	modest	modest	ADJ
dti-1314	167	18	increase	increase	NOUN
dti-1314	167	19	in	in	ADP
dti-1314	167	20	ass	ass	NOUN
dti-1314	167	21	expression	expression	NOUN
dti-1314	167	22	does	do	AUX
dti-1314	167	23	affect	affect	VERB
dti-1314	167	24	slightly	slightly	ADV
dti-1314	167	25	the	the	DET
dti-1314	167	26	id50	id50	PROPN
dti-1314	167	27	of	of	ADP
dti-1314	167	28	adi	adi	PROPN
dti-1314	167	29	-	-	PUNCT
dti-1314	167	30	peg20	peg20	PROPN
dti-1314	167	31	with	with	ADP
dti-1314	167	32	2	2	NUM
dti-1314	167	33	fold	fold	ADJ
dti-1314	167	34	increase	increase	NOUN
dti-1314	167	35	.	.	PUNCT
dti-1314	168	1	a375	a375	PROPN
dti-1314	168	2	sk	sk	PROPN
dti-1314	168	3	-	-	PUNCT
dti-1314	168	4	mel-2	mel-2	ADJ
dti-1314	168	5	a2058	a2058	PROPN
dti-1314	168	6	mel-1220	mel-1220	NOUN
dti-1314	168	7	ass	ass	NOUN
dti-1314	168	8	actin	actin	NOUN
dti-1314	168	9	+	+	X
dti-1314	168	10	+	+	PUNCT
dti-1314	168	11	+	+	CCONJ
dti-1314	168	12	+	+	ADJ
dti-1314	168	13	adi	adi	NOUN
dti-1314	168	14	ratio	ratio	NOUN
dti-1314	168	15	of	of	ADP
dti-1314	168	16	ass	ass	NOUN
dti-1314	168	17	1.52	1.52	NUM
dti-1314	168	18	2.03	2.03	NUM
dti-1314	168	19	2.76	2.76	NUM
dti-1314	168	20	1	1	NUM
dti-1314	168	21	figure	figure	NOUN
dti-1314	168	22	4	4	NUM
dti-1314	168	23	.	.	PUNCT
dti-1314	168	24	immunoblot	immunoblot	NOUN
dti-1314	168	25	of	of	ADP
dti-1314	168	26	ass	ass	NOUN
dti-1314	168	27	protein	protein	NOUN
dti-1314	168	28	in	in	ADP
dti-1314	168	29	4	4	NUM
dti-1314	168	30	melanoma	melanoma	NOUN
dti-1314	168	31	cell	cell	NOUN
dti-1314	168	32	lines	line	NOUN
dti-1314	168	33	(	(	PUNCT
dti-1314	168	34	a375	a375	PROPN
dti-1314	168	35	,	,	PUNCT
dti-1314	168	36	sk	sk	NOUN
dti-1314	168	37	-	-	PUNCT
dti-1314	168	38	mel-2	mel-2	NOUN
dti-1314	168	39	,	,	PUNCT
dti-1314	168	40	a2058	a2058	NUM
dti-1314	168	41	and	and	CCONJ
dti-1314	168	42	mel-1220	mel-1220	ADJ
dti-1314	168	43	)	)	PUNCT
dti-1314	168	44	before	before	ADP
dti-1314	168	45	and	and	CCONJ
dti-1314	168	46	after	after	ADP
dti-1314	168	47	exposure	exposure	NOUN
dti-1314	168	48	to	to	ADP
dti-1314	168	49	adi	adi	NOUN
dti-1314	168	50	-	-	PUNCT
dti-1314	168	51	peg20	peg20	NOUN
dti-1314	168	52	for	for	ADP
dti-1314	168	53	3	3	NUM
dti-1314	168	54	days	day	NOUN
dti-1314	168	55	.	.	PUNCT
dti-1314	169	1	the	the	DET
dti-1314	169	2	ratio	ratio	NOUN
dti-1314	169	3	of	of	ADP
dti-1314	169	4	ass	ass	NOUN
dti-1314	169	5	depicts	depict	VERB
dti-1314	169	6	the	the	DET
dti-1314	169	7	intensity	intensity	NOUN
dti-1314	169	8	of	of	ADP
dti-1314	169	9	ass	ass	NOUN
dti-1314	169	10	expression	expression	NOUN
dti-1314	169	11	by	by	ADP
dti-1314	169	12	densitometer	densitometer	NOUN
dti-1314	169	13	after	after	ADP
dti-1314	169	14	exposure	exposure	NOUN
dti-1314	169	15	to	to	ADP
dti-1314	169	16	adi	adi	PROPN
dti-1314	169	17	versus	versus	ADP
dti-1314	169	18	control	control	PROPN
dti-1314	169	19	background	background	NOUN
dti-1314	169	20	.	.	PUNCT
dti-1314	170	1	a2058	a2058	PROPN
dti-1314	170	2	exhibited	exhibit	VERB
dti-1314	170	3	the	the	DET
dti-1314	170	4	highest	high	ADJ
dti-1314	170	5	level	level	NOUN
dti-1314	170	6	of	of	ADP
dti-1314	170	7	expression	expression	NOUN
dti-1314	170	8	whereas	whereas	SCONJ
dti-1314	170	9	mel-1220	mel-1220	NOUN
dti-1314	170	10	did	do	AUX
dti-1314	170	11	not	not	PART
dti-1314	170	12	express	express	VERB
dti-1314	170	13	ass	ass	NOUN
dti-1314	170	14	after	after	ADP
dti-1314	170	15	exposure	exposure	NOUN
dti-1314	170	16	to	to	ADP
dti-1314	170	17	adi	adi	PROPN
dti-1314	170	18	-	-	PUNCT
dti-1314	170	19	peg20	peg20	PROPN
dti-1314	170	20	.	.	PUNCT
dti-1314	171	1	125	125	NUM
dti-1314	171	2	argininosuccinate	argininosuccinate	NOUN
dti-1314	171	3	synthetase	synthetase	NOUN
dti-1314	171	4	in	in	ADP
dti-1314	171	5	melanoma	melanoma	NOUN
dti-1314	171	6	drug	drug	NOUN
dti-1314	171	7	target	target	NOUN
dti-1314	171	8	insights	insight	NOUN
dti-1314	171	9	2007	2007	NUM
dti-1314	171	10	:	:	PUNCT
dti-1314	171	11	2	2	NUM
dti-1314	171	12	been	be	AUX
dti-1314	171	13	shown	show	VERB
dti-1314	171	14	by	by	ADP
dti-1314	171	15	several	several	ADJ
dti-1314	171	16	investigators	investigator	NOUN
dti-1314	171	17	to	to	PART
dti-1314	171	18	have	have	VERB
dti-1314	171	19	antitumor	antitumor	NOUN
dti-1314	171	20	activity	activity	NOUN
dti-1314	171	21	in	in	ADP
dti-1314	171	22	melanoma	melanoma	NOUN
dti-1314	171	23	cell	cell	NOUN
dti-1314	171	24	lines	line	NOUN
dti-1314	171	25	as	as	ADV
dti-1314	171	26	well	well	ADV
dti-1314	171	27	as	as	ADP
dti-1314	171	28	in	in	ADP
dti-1314	171	29	other	other	ADJ
dti-1314	171	30	tumor	tumor	NOUN
dti-1314	171	31	cell	cell	NOUN
dti-1314	171	32	lines	line	NOUN
dti-1314	171	33	which	which	PRON
dti-1314	171	34	lack	lack	VERB
dti-1314	171	35	ass	ass	NOUN
dti-1314	171	36	in	in	ADP
dti-1314	171	37	vitro	vitro	X
dti-1314	171	38	(	(	PUNCT
dti-1314	171	39	dillon	dillon	PROPN
dti-1314	171	40	et	et	PROPN
dti-1314	171	41	al	al	PROPN
dti-1314	171	42	.	.	PROPN
dti-1314	171	43	2004	2004	NUM
dti-1314	171	44	;	;	PUNCT
dti-1314	171	45	ensor	ensor	PROPN
dti-1314	171	46	et	et	PROPN
dti-1314	171	47	al	al	PROPN
dti-1314	171	48	.	.	PROPN
dti-1314	171	49	2002	2002	NUM
dti-1314	171	50	;	;	PUNCT
dti-1314	171	51	gong	gong	PROPN
dti-1314	171	52	et	et	PROPN
dti-1314	171	53	al	al	PROPN
dti-1314	171	54	.	.	PROPN
dti-1314	171	55	2000	2000	NUM
dti-1314	171	56	;	;	PUNCT
dti-1314	171	57	miyazaki	miyazaki	PROPN
dti-1314	171	58	et	et	PROPN
dti-1314	171	59	al	al	PROPN
dti-1314	171	60	.	.	PROPN
dti-1314	171	61	1990	1990	NUM
dti-1314	171	62	;	;	PUNCT
dti-1314	171	63	noh	noh	PROPN
dti-1314	171	64	et	et	PROPN
dti-1314	171	65	al	al	PROPN
dti-1314	171	66	.	.	PROPN
dti-1314	171	67	2004	2004	NUM
dti-1314	171	68	;	;	PUNCT
dti-1314	171	69	shen	shen	PROPN
dti-1314	171	70	et	et	PROPN
dti-1314	171	71	al	al	PROPN
dti-1314	171	72	.	.	PROPN
dti-1314	171	73	2006	2006	NUM
dti-1314	171	74	;	;	PUNCT
dti-1314	171	75	sugimura	sugimura	NOUN
dti-1314	171	76	et	et	PROPN
dti-1314	171	77	al	al	PROPN
dti-1314	171	78	.	.	PROPN
dti-1314	171	79	1992	1992	NUM
dti-1314	171	80	;	;	PUNCT
dti-1314	171	81	szlosarek	szlosarek	PROPN
dti-1314	171	82	et	et	PROPN
dti-1314	171	83	al	al	PROPN
dti-1314	171	84	.	.	PROPN
dti-1314	171	85	2006	2006	NUM
dti-1314	171	86	;	;	PUNCT
dti-1314	171	87	takaku	takaku	NOUN
dti-1314	171	88	et	et	PROPN
dti-1314	171	89	al	al	PROPN
dti-1314	171	90	.	.	PROPN
dti-1314	171	91	1995	1995	NUM
dti-1314	171	92	;	;	PUNCT
dti-1314	171	93	takaku	takaku	NOUN
dti-1314	171	94	et	et	PROPN
dti-1314	171	95	al	al	PROPN
dti-1314	171	96	.	.	PROPN
dti-1314	171	97	1993	1993	NUM
dti-1314	171	98	;	;	PUNCT
dti-1314	171	99	yoon	yoon	PROPN
dti-1314	171	100	et	et	PROPN
dti-1314	171	101	al	al	PROPN
dti-1314	171	102	.	.	PROPN
dti-1314	171	103	2007	2007	NUM
dti-1314	171	104	)	)	PUNCT
dti-1314	171	105	.	.	PUNCT
dti-1314	172	1	correlation	correlation	NOUN
dti-1314	172	2	of	of	ADP
dti-1314	172	3	antiproliferative	antiproliferative	ADJ
dti-1314	172	4	effect	effect	NOUN
dti-1314	172	5	of	of	ADP
dti-1314	172	6	adi	adi	NOUN
dti-1314	172	7	-	-	PUNCT
dti-1314	172	8	peg20	peg20	PROPN
dti-1314	172	9	with	with	ADP
dti-1314	172	10	endogenous	endogenous	ADJ
dti-1314	172	11	ass	ass	NOUN
dti-1314	172	12	levels	level	NOUN
dti-1314	172	13	also	also	ADV
dti-1314	172	14	has	have	AUX
dti-1314	172	15	been	be	AUX
dti-1314	172	16	reported	report	VERB
dti-1314	172	17	(	(	PUNCT
dti-1314	172	18	ensor	ensor	PROPN
dti-1314	172	19	et	et	PROPN
dti-1314	172	20	al	al	PROPN
dti-1314	172	21	.	.	PROPN
dti-1314	172	22	2002	2002	NUM
dti-1314	172	23	;	;	PUNCT
dti-1314	172	24	shen	shen	PROPN
dti-1314	172	25	et	et	PROPN
dti-1314	172	26	al	al	PROPN
dti-1314	172	27	.	.	PROPN
dti-1314	172	28	2003	2003	NUM
dti-1314	172	29	)	)	PUNCT
dti-1314	172	30	.	.	PUNCT
dti-1314	173	1	however	however	ADV
dti-1314	173	2	,	,	PUNCT
dti-1314	173	3	these	these	DET
dti-1314	173	4	enzymes	enzyme	NOUN
dti-1314	173	5	have	have	VERB
dti-1314	173	6	a	a	DET
dti-1314	173	7	short	short	ADJ
dti-1314	173	8	half	half	ADJ
dti-1314	173	9	life	life	NOUN
dti-1314	173	10	and	and	CCONJ
dti-1314	173	11	high	high	ADJ
dti-1314	173	12	antigenicity	antigenicity	NOUN
dti-1314	173	13	which	which	PRON
dti-1314	173	14	makes	make	VERB
dti-1314	173	15	them	they	PRON
dti-1314	173	16	not	not	PART
dti-1314	173	17	suitable	suitable	ADJ
dti-1314	173	18	for	for	ADP
dti-1314	173	19	in	in	ADP
dti-1314	173	20	vivo	vivo	NOUN
dti-1314	173	21	use	use	NOUN
dti-1314	173	22	.	.	PUNCT
dti-1314	174	1	to	to	PART
dti-1314	174	2	overcome	overcome	VERB
dti-1314	174	3	this	this	DET
dti-1314	174	4	problem	problem	NOUN
dti-1314	174	5	,	,	PUNCT
dti-1314	174	6	a	a	DET
dti-1314	174	7	pegylated	pegylated	ADJ
dti-1314	174	8	form	form	NOUN
dti-1314	174	9	of	of	ADP
dti-1314	174	10	adi	adi	PROPN
dti-1314	174	11	(	(	PUNCT
dti-1314	174	12	adi	adi	NOUN
dti-1314	174	13	-	-	PUNCT
dti-1314	174	14	peg20	peg20	PROPN
dti-1314	174	15	)	)	PUNCT
dti-1314	174	16	was	be	AUX
dti-1314	174	17	developed	develop	VERB
dti-1314	174	18	by	by	ADP
dti-1314	174	19	polaris	polaris	PROPN
dti-1314	174	20	inc	inc	PROPN
dti-1314	174	21	.	.	PROPN
dti-1314	174	22	and	and	CCONJ
dti-1314	174	23	has	have	AUX
dti-1314	174	24	been	be	AUX
dti-1314	174	25	shown	show	VERB
dti-1314	174	26	to	to	PART
dti-1314	174	27	increase	increase	VERB
dti-1314	174	28	the	the	DET
dti-1314	174	29	half	half	ADJ
dti-1314	174	30	life	life	NOUN
dti-1314	174	31	as	as	ADV
dti-1314	174	32	well	well	ADV
dti-1314	174	33	as	as	ADP
dti-1314	174	34	decrease	decrease	VERB
dti-1314	174	35	the	the	DET
dti-1314	174	36	antigenicity	antigenicity	NOUN
dti-1314	174	37	(	(	PUNCT
dti-1314	174	38	izzo	izzo	PROPN
dti-1314	174	39	et	et	PROPN
dti-1314	174	40	al	al	PROPN
dti-1314	174	41	.	.	PROPN
dti-1314	174	42	2004	2004	NUM
dti-1314	174	43	)	)	PUNCT
dti-1314	174	44	.	.	PUNCT
dti-1314	175	1	this	this	DET
dti-1314	175	2	compound	compound	NOUN
dti-1314	175	3	has	have	AUX
dti-1314	175	4	been	be	AUX
dti-1314	175	5	shown	show	VERB
dti-1314	175	6	to	to	PART
dti-1314	175	7	have	have	VERB
dti-1314	175	8	antitumor	antitumor	NOUN
dti-1314	175	9	activity	activity	NOUN
dti-1314	175	10	in	in	ADP
dti-1314	175	11	vivo	vivo	NOUN
dti-1314	175	12	(	(	PUNCT
dti-1314	175	13	ensor	ensor	PROPN
dti-1314	175	14	et	et	PROPN
dti-1314	175	15	al	al	PROPN
dti-1314	175	16	.	.	PROPN
dti-1314	175	17	2002	2002	NUM
dti-1314	175	18	)	)	PUNCT
dti-1314	175	19	.	.	PUNCT
dti-1314	176	1	clinical	clinical	ADJ
dti-1314	176	2	trials	trial	NOUN
dti-1314	176	3	also	also	ADV
dti-1314	176	4	look	look	VERB
dti-1314	176	5	promising	promise	VERB
dti-1314	176	6	with	with	ADP
dti-1314	176	7	antitumor	antitumor	PROPN
dti-1314	176	8	responses	response	NOUN
dti-1314	176	9	seen	see	VERB
dti-1314	176	10	in	in	ADP
dti-1314	176	11	a	a	DET
dti-1314	176	12	number	number	NOUN
dti-1314	176	13	of	of	ADP
dti-1314	176	14	melanoma	melanoma	NOUN
dti-1314	176	15	patients	patient	NOUN
dti-1314	176	16	(	(	PUNCT
dti-1314	176	17	ascierto	ascierto	PROPN
dti-1314	176	18	et	et	PROPN
dti-1314	176	19	al	al	PROPN
dti-1314	176	20	.	.	PROPN
dti-1314	176	21	2005	2005	NUM
dti-1314	176	22	;	;	PUNCT
dti-1314	176	23	feun	feun	VERB
dti-1314	176	24	and	and	CCONJ
dti-1314	176	25	savaraj	savaraj	ADJ
dti-1314	176	26	,	,	PUNCT
dti-1314	176	27	2006	2006	NUM
dti-1314	176	28	)	)	PUNCT
dti-1314	176	29	.	.	PUNCT
dti-1314	177	1	however	however	ADV
dti-1314	177	2	,	,	PUNCT
dti-1314	177	3	not	not	PART
dti-1314	177	4	all	all	DET
dti-1314	177	5	patients	patient	NOUN
dti-1314	177	6	respond	respond	VERB
dti-1314	177	7	to	to	ADP
dti-1314	177	8	adi	adi	NOUN
dti-1314	177	9	-	-	PUNCT
dti-1314	177	10	peg20	peg20	PROPN
dti-1314	177	11	and	and	CCONJ
dti-1314	177	12	resistance	resistance	NOUN
dti-1314	177	13	to	to	ADP
dti-1314	177	14	this	this	DET
dti-1314	177	15	compound	compound	NOUN
dti-1314	177	16	does	do	AUX
dti-1314	177	17	occur	occur	VERB
dti-1314	177	18	after	after	ADP
dti-1314	177	19	treatment	treatment	NOUN
dti-1314	177	20	.	.	PUNCT
dti-1314	178	1	our	our	PRON
dti-1314	178	2	limited	limited	ADJ
dti-1314	178	3	clinical	clinical	ADJ
dti-1314	178	4	data	datum	NOUN
dti-1314	178	5	suggest	suggest	VERB
dti-1314	178	6	that	that	SCONJ
dti-1314	178	7	ass	ass	NOUN
dti-1314	178	8	expression	expression	NOUN
dti-1314	178	9	occurs	occur	VERB
dti-1314	178	10	in	in	ADP
dti-1314	178	11	patients	patient	NOUN
dti-1314	178	12	who	who	PRON
dti-1314	178	13	develop	develop	VERB
dti-1314	178	14	resistance	resistance	NOUN
dti-1314	178	15	to	to	ADP
dti-1314	178	16	adi	adi	NOUN
dti-1314	178	17	-	-	PUNCT
dti-1314	178	18	peg20	peg20	PROPN
dti-1314	178	19	(	(	PUNCT
dti-1314	178	20	feun	feun	VERB
dti-1314	178	21	and	and	CCONJ
dti-1314	178	22	savaraj	savaraj	ADJ
dti-1314	178	23	,	,	PUNCT
dti-1314	178	24	2006	2006	NUM
dti-1314	178	25	)	)	PUNCT
dti-1314	178	26	.	.	PUNCT
dti-1314	179	1	thus	thus	ADV
dti-1314	179	2	,	,	PUNCT
dti-1314	179	3	it	it	PRON
dti-1314	179	4	appears	appear	VERB
dti-1314	179	5	that	that	SCONJ
dti-1314	179	6	exposure	exposure	NOUN
dti-1314	179	7	to	to	ADP
dti-1314	179	8	adi	adi	NOUN
dti-1314	179	9	-	-	PUNCT
dti-1314	179	10	peg20	peg20	NOUN
dti-1314	179	11	which	which	PRON
dti-1314	179	12	results	result	VERB
dti-1314	179	13	in	in	ADP
dti-1314	179	14	continuous	continuous	ADJ
dti-1314	179	15	arginine	arginine	NOUN
dti-1314	179	16	depletion	depletion	NOUN
dti-1314	179	17	in	in	ADP
dti-1314	179	18	the	the	DET
dti-1314	179	19	serum	serum	NOUN
dti-1314	179	20	results	result	NOUN
dti-1314	179	21	in	in	ADP
dti-1314	179	22	ass	ass	NOUN
dti-1314	179	23	expression	expression	NOUN
dti-1314	179	24	and	and	CCONJ
dti-1314	179	25	hence	hence	ADV
dti-1314	179	26	drug	drug	NOUN
dti-1314	179	27	resistance	resistance	NOUN
dti-1314	179	28	.	.	PUNCT
dti-1314	180	1	in	in	ADP
dti-1314	180	2	this	this	DET
dti-1314	180	3	communication	communication	NOUN
dti-1314	180	4	,	,	PUNCT
dti-1314	180	5	we	we	PRON
dti-1314	180	6	have	have	AUX
dti-1314	180	7	shown	show	VERB
dti-1314	180	8	that	that	DET
dti-1314	180	9	exposure	exposure	NOUN
dti-1314	180	10	of	of	ADP
dti-1314	180	11	melanoma	melanoma	NOUN
dti-1314	180	12	cells	cell	NOUN
dti-1314	180	13	to	to	ADP
dti-1314	180	14	adi	adi	NOUN
dti-1314	180	15	-	-	PUNCT
dti-1314	180	16	peg20	peg20	PROPN
dti-1314	180	17	or	or	CCONJ
dti-1314	180	18	arginine	arginine	NOUN
dti-1314	180	19	free	free	ADJ
dti-1314	180	20	media	medium	NOUN
dti-1314	180	21	can	can	AUX
dti-1314	180	22	result	result	VERB
dti-1314	180	23	in	in	ADP
dti-1314	180	24	ass	ass	NOUN
dti-1314	180	25	protein	protein	NOUN
dti-1314	180	26	production	production	NOUN
dti-1314	180	27	which	which	PRON
dti-1314	180	28	again	again	ADV
dti-1314	180	29	become	become	VERB
dti-1314	180	30	negligible	negligible	ADJ
dti-1314	180	31	when	when	SCONJ
dti-1314	180	32	cells	cell	NOUN
dti-1314	180	33	were	be	AUX
dti-1314	180	34	exposed	expose	VERB
dti-1314	180	35	to	to	ADP
dti-1314	180	36	normal	normal	ADJ
dti-1314	180	37	media	medium	NOUN
dti-1314	180	38	.	.	PUNCT
dti-1314	181	1	interestingly	interestingly	ADV
dti-1314	181	2	,	,	PUNCT
dti-1314	181	3	the	the	DET
dti-1314	181	4	levels	level	NOUN
dti-1314	181	5	of	of	ADP
dti-1314	181	6	ass	ass	NOUN
dti-1314	181	7	protein	protein	NOUN
dti-1314	181	8	being	be	AUX
dti-1314	181	9	induced	induce	VERB
dti-1314	181	10	while	while	SCONJ
dti-1314	181	11	cells	cell	NOUN
dti-1314	181	12	are	be	AUX
dti-1314	181	13	deprived	deprive	VERB
dti-1314	181	14	with	with	ADP
dti-1314	181	15	arginine	arginine	NOUN
dti-1314	181	16	vary	vary	VERB
dti-1314	181	17	among	among	ADP
dti-1314	181	18	the	the	DET
dti-1314	181	19	4	4	NUM
dti-1314	181	20	melanoma	melanoma	NOUN
dti-1314	181	21	cell	cell	NOUN
dti-1314	181	22	lines	line	NOUN
dti-1314	181	23	.	.	PUNCT
dti-1314	182	1	a2058	a2058	PROPN
dti-1314	182	2	has	have	VERB
dti-1314	182	3	the	the	DET
dti-1314	182	4	highest	high	ADJ
dti-1314	182	5	of	of	ADP
dti-1314	182	6	ass	ass	NOUN
dti-1314	182	7	protein	protein	NOUN
dti-1314	182	8	followed	follow	VERB
dti-1314	182	9	by	by	ADP
dti-1314	182	10	sk	sk	NOUN
dti-1314	182	11	-	-	PUNCT
dti-1314	182	12	mel-2	mel-2	PUNCT
dti-1314	182	13	and	and	CCONJ
dti-1314	182	14	a375	a375	PROPN
dti-1314	182	15	.	.	PUNCT
dti-1314	183	1	one	one	NUM
dti-1314	183	2	melanoma	melanoma	NOUN
dti-1314	183	3	cell	cell	NOUN
dti-1314	183	4	line	line	NOUN
dti-1314	183	5	(	(	PUNCT
dti-1314	183	6	mel	mel	NOUN
dti-1314	183	7	-1220	-1220	PROPN
dti-1314	183	8	)	)	PUNCT
dti-1314	183	9	can	can	AUX
dti-1314	183	10	not	not	PART
dti-1314	183	11	produce	produce	VERB
dti-1314	183	12	ass	ass	NOUN
dti-1314	183	13	protein	protein	NOUN
dti-1314	183	14	despite	despite	SCONJ
dti-1314	183	15	being	be	AUX
dti-1314	183	16	cultured	cultured	ADJ
dti-1314	183	17	in	in	ADP
dti-1314	183	18	the	the	DET
dti-1314	183	19	arginine	arginine	NOUN
dti-1314	183	20	depleted	deplete	VERB
dti-1314	183	21	media	medium	NOUN
dti-1314	183	22	.	.	PUNCT
dti-1314	184	1	interestingly	interestingly	ADV
dti-1314	184	2	,	,	PUNCT
dti-1314	184	3	a2058	a2058	PROPN
dti-1314	184	4	can	can	AUX
dti-1314	184	5	be	be	AUX
dti-1314	184	6	selected	select	VERB
dti-1314	184	7	to	to	PART
dti-1314	184	8	become	become	VERB
dti-1314	184	9	resistant	resistant	ADJ
dti-1314	184	10	to	to	ADP
dti-1314	184	11	adi	adi	NOUN
dti-1314	184	12	-	-	PUNCT
dti-1314	184	13	peg20	peg20	PROPN
dti-1314	184	14	rather	rather	ADV
dti-1314	184	15	rapidly	rapidly	ADV
dti-1314	184	16	in	in	ADP
dti-1314	184	17	6	6	NUM
dti-1314	184	18	weeks	week	NOUN
dti-1314	184	19	.	.	PUNCT
dti-1314	185	1	the	the	DET
dti-1314	185	2	primary	primary	ADJ
dti-1314	185	3	mechanism	mechanism	NOUN
dti-1314	185	4	of	of	ADP
dti-1314	185	5	resistance	resistance	NOUN
dti-1314	185	6	involves	involve	VERB
dti-1314	185	7	increase	increase	NOUN
dti-1314	185	8	in	in	ADP
dti-1314	185	9	ass	ass	NOUN
dti-1314	185	10	protein	protein	NOUN
dti-1314	185	11	production	production	NOUN
dti-1314	185	12	followed	follow	VERB
dti-1314	185	13	by	by	ADP
dti-1314	185	14	ass	ass	NOUN
dti-1314	185	15	transcription	transcription	NOUN
dti-1314	185	16	as	as	SCONJ
dti-1314	185	17	detected	detect	VERB
dti-1314	185	18	by	by	ADP
dti-1314	185	19	northernblot	northernblot	ADJ
dti-1314	185	20	analysis	analysis	NOUN
dti-1314	185	21	.	.	PUNCT
dti-1314	186	1	the	the	DET
dti-1314	186	2	resistance	resistance	NOUN
dti-1314	186	3	also	also	ADV
dti-1314	186	4	is	be	AUX
dti-1314	186	5	irreversible	irreversible	ADJ
dti-1314	186	6	despite	despite	SCONJ
dti-1314	186	7	replacement	replacement	NOUN
dti-1314	186	8	with	with	ADP
dti-1314	186	9	normal	normal	ADJ
dti-1314	186	10	emem	emem	ADJ
dti-1314	186	11	media	medium	NOUN
dti-1314	186	12	.	.	PUNCT
dti-1314	187	1	on	on	ADP
dti-1314	187	2	the	the	DET
dti-1314	187	3	other	other	ADJ
dti-1314	187	4	hand	hand	NOUN
dti-1314	187	5	,	,	PUNCT
dti-1314	187	6	mel-1220	mel-1220	NOUN
dti-1314	187	7	can	can	AUX
dti-1314	187	8	not	not	PART
dti-1314	187	9	be	be	AUX
dti-1314	187	10	made	make	VERB
dti-1314	187	11	resistant	resistant	ADJ
dti-1314	187	12	to	to	ADP
dti-1314	187	13	adipeg20	adipeg20	PROPN
dti-1314	187	14	.	.	PUNCT
dti-1314	188	1	these	these	DET
dti-1314	188	2	fi	fi	NOUN
dti-1314	188	3	ndings	nding	NOUN
dti-1314	188	4	may	may	AUX
dti-1314	188	5	mirror	mirror	VERB
dti-1314	188	6	what	what	PRON
dti-1314	188	7	we	we	PRON
dti-1314	188	8	have	have	AUX
dti-1314	188	9	found	find	VERB
dti-1314	188	10	in	in	ADP
dti-1314	188	11	melanoma	melanoma	NOUN
dti-1314	188	12	patients	patient	NOUN
dti-1314	188	13	.	.	PUNCT
dti-1314	189	1	this	this	PRON
dti-1314	189	2	is	be	AUX
dti-1314	189	3	the	the	DET
dti-1314	189	4	fi	fi	NOUN
dti-1314	189	5	rst	rst	NOUN
dti-1314	189	6	report	report	NOUN
dti-1314	189	7	which	which	PRON
dti-1314	189	8	demonstrated	demonstrate	VERB
dti-1314	189	9	that	that	SCONJ
dti-1314	189	10	extracellular	extracellular	ADJ
dti-1314	189	11	arginine	arginine	NOUN
dti-1314	189	12	does	do	AUX
dti-1314	189	13	control	control	VERB
dti-1314	189	14	ass	ass	NOUN
dti-1314	189	15	protein	protein	NOUN
dti-1314	189	16	in	in	ADP
dti-1314	189	17	certain	certain	ADJ
dti-1314	189	18	melanoma	melanoma	NOUN
dti-1314	189	19	cells	cell	NOUN
dti-1314	189	20	.	.	PUNCT
dti-1314	190	1	the	the	DET
dti-1314	190	2	underlying	underlie	VERB
dti-1314	190	3	mechanism(s	mechanism(s	NOUN
dti-1314	190	4	)	)	PUNCT
dti-1314	190	5	on	on	ADP
dti-1314	190	6	how	how	SCONJ
dti-1314	190	7	arginine	arginine	NOUN
dti-1314	190	8	controls	control	VERB
dti-1314	190	9	ass	ass	NOUN
dti-1314	190	10	translation	translation	NOUN
dti-1314	190	11	/	/	SYM
dti-1314	190	12	transcription	transcription	NOUN
dti-1314	190	13	in	in	ADP
dti-1314	190	14	melanoma	melanoma	NOUN
dti-1314	190	15	are	be	AUX
dti-1314	190	16	not	not	PART
dti-1314	190	17	known	know	VERB
dti-1314	190	18	.	.	PUNCT
dti-1314	191	1	it	it	PRON
dti-1314	191	2	is	be	AUX
dti-1314	191	3	possible	possible	ADJ
dti-1314	191	4	that	that	SCONJ
dti-1314	191	5	when	when	SCONJ
dti-1314	191	6	the	the	DET
dti-1314	191	7	arginine	arginine	NOUN
dti-1314	191	8	levels	level	NOUN
dti-1314	191	9	is	be	AUX
dti-1314	191	10	low	low	ADJ
dti-1314	191	11	,	,	PUNCT
dti-1314	191	12	the	the	DET
dti-1314	191	13	cells	cell	NOUN
dti-1314	191	14	will	will	AUX
dti-1314	191	15	attempt	attempt	VERB
dti-1314	191	16	to	to	PART
dti-1314	191	17	increase	increase	VERB
dti-1314	191	18	the	the	DET
dti-1314	191	19	translation	translation	NOUN
dti-1314	191	20	of	of	ADP
dti-1314	191	21	ass	ass	NOUN
dti-1314	191	22	in	in	ADP
dti-1314	191	23	order	order	NOUN
dti-1314	191	24	to	to	PART
dti-1314	191	25	synthesize	synthesize	VERB
dti-1314	191	26	arginine	arginine	NOUN
dti-1314	191	27	from	from	ADP
dti-1314	191	28	citrulline	citrulline	NOUN
dti-1314	191	29	.	.	PUNCT
dti-1314	192	1	we	we	PRON
dti-1314	192	2	are	be	AUX
dti-1314	192	3	m	m	PROPN
dti-1314	192	4	ar	ar	NOUN
dti-1314	192	5	ke	ke	PROPN
dti-1314	192	6	r	r	PROPN
dti-1314	192	7	a3	a3	NOUN
dti-1314	192	8	75	75	NUM
dti-1314	192	9	-2	-2	NOUN
dti-1314	192	10	a3	a3	PROPN
dti-1314	192	11	75	75	NUM
dti-1314	192	12	-3	-3	PUNCT
dti-1314	192	13	a3	a3	NOUN
dti-1314	192	14	75	75	NUM
dti-1314	192	15	-4	-4	PUNCT
dti-1314	192	16	a	a	DET
dti-1314	192	17	37	37	NUM
dti-1314	192	18	5	5	NUM
dti-1314	192	19	a	a	DET
dti-1314	192	20	20	20	NUM
dti-1314	192	21	58	58	NUM
dti-1314	192	22	-5	-5	NOUN
dti-1314	192	23	a	a	DET
dti-1314	192	24	20	20	NUM
dti-1314	192	25	58	58	NUM
dti-1314	193	1	-6	-6	NOUN
dti-1314	193	2	a	a	DET
dti-1314	193	3	20	20	NUM
dti-1314	193	4	58	58	NUM
dti-1314	193	5	ass	ass	NOUN
dti-1314	193	6	gapdh	gapdh	NOUN
dti-1314	193	7	ass	ass	NOUN
dti-1314	193	8	actin	actin	NOUN
dti-1314	193	9	1	1	NUM
dti-1314	193	10	2	2	NUM
dti-1314	193	11	3	3	NUM
dti-1314	193	12	4	4	NUM
dti-1314	193	13	figure	figure	NOUN
dti-1314	193	14	7b	7b	NUM
dti-1314	193	15	.	.	PUNCT
dti-1314	194	1	immunoblot	immunoblot	PROPN
dti-1314	194	2	of	of	ADP
dti-1314	194	3	ass	ass	NOUN
dti-1314	194	4	in	in	ADP
dti-1314	194	5	control	control	NOUN
dti-1314	194	6	and	and	CCONJ
dti-1314	194	7	transfected	transfecte	VERB
dti-1314	194	8	cells	cell	NOUN
dti-1314	194	9	.	.	PUNCT
dti-1314	195	1	lane	lane	NOUN
dti-1314	195	2	1	1	NUM
dti-1314	195	3	:	:	PUNCT
dti-1314	195	4	a-375	a-375	PROPN
dti-1314	195	5	.	.	PUNCT
dti-1314	196	1	lane	lane	NOUN
dti-1314	196	2	2	2	NUM
dti-1314	196	3	:	:	PUNCT
dti-1314	196	4	a375	a375	PROPN
dti-1314	196	5	-	-	SYM
dti-1314	196	6	3	3	NUM
dti-1314	196	7	.	.	X
dti-1314	196	8	lane	lane	NOUN
dti-1314	196	9	3	3	NUM
dti-1314	196	10	:	:	PUNCT
dti-1314	196	11	a2058	a2058	PROPN
dti-1314	196	12	.	.	PROPN
dti-1314	196	13	lane	lane	NOUN
dti-1314	196	14	4	4	NUM
dti-1314	196	15	:	:	PUNCT
dti-1314	196	16	a2058	a2058	NOUN
dti-1314	196	17	-	-	SYM
dti-1314	196	18	6	6	NUM
dti-1314	196	19	(	(	PUNCT
dti-1314	196	20	a375	a375	PROPN
dti-1314	196	21	-	-	SYM
dti-1314	196	22	3	3	NUM
dti-1314	196	23	and	and	CCONJ
dti-1314	196	24	a2058	a2058	NOUN
dti-1314	196	25	-	-	SYM
dti-1314	196	26	6	6	NUM
dti-1314	196	27	transfected	transfecte	VERB
dti-1314	196	28	with	with	ADP
dti-1314	196	29	ass	ass	NOUN
dti-1314	196	30	)	)	PUNCT
dti-1314	196	31	.	.	PUNCT
dti-1314	197	1	figure	figure	NOUN
dti-1314	197	2	7a	7a	NUM
dti-1314	197	3	.	.	PUNCT
dti-1314	198	1	rt	rt	NOUN
dti-1314	198	2	-	-	PUNCT
dti-1314	198	3	pcr	pcr	PROPN
dti-1314	198	4	of	of	ADP
dti-1314	198	5	ass	ass	NOUN
dti-1314	198	6	in	in	ADP
dti-1314	198	7	a375	a375	PROPN
dti-1314	198	8	and	and	CCONJ
dti-1314	198	9	a2058	a2058	PROPN
dti-1314	198	10	and	and	CCONJ
dti-1314	198	11	their	their	PRON
dti-1314	198	12	ass	ass	NOUN
dti-1314	198	13	transfected	transfecte	VERB
dti-1314	198	14	clones	clone	NOUN
dti-1314	198	15	a375	a375	PROPN
dti-1314	198	16	-	-	SYM
dti-1314	198	17	2	2	NUM
dti-1314	198	18	,	,	PUNCT
dti-1314	198	19	a375	a375	PROPN
dti-1314	198	20	-	-	SYM
dti-1314	198	21	3	3	NUM
dti-1314	198	22	,	,	PUNCT
dti-1314	198	23	a375	a375	PROPN
dti-1314	198	24	-	-	PUNCT
dti-1314	198	25	4	4	NUM
dti-1314	198	26	.	.	NUM
dti-1314	198	27	and	and	CCONJ
dti-1314	198	28	a2058	a2058	NOUN
dti-1314	198	29	-	-	PUNCT
dti-1314	198	30	5,a2058	5,a2058	NUM
dti-1314	198	31	-	-	SYM
dti-1314	198	32	6	6	NUM
dti-1314	198	33	,	,	PUNCT
dti-1314	198	34	respectively	respectively	ADV
dti-1314	198	35	.	.	PUNCT
dti-1314	199	1	a375	a375	PROPN
dti-1314	199	2	-	-	SYM
dti-1314	199	3	3	3	NUM
dti-1314	199	4	,	,	PUNCT
dti-1314	199	5	and	and	CCONJ
dti-1314	199	6	a2058	a2058	NOUN
dti-1314	199	7	-	-	SYM
dti-1314	199	8	6	6	NUM
dti-1314	199	9	possess	possess	NOUN
dti-1314	199	10	high	high	ADJ
dti-1314	199	11	levels	level	NOUN
dti-1314	199	12	of	of	ADP
dti-1314	199	13	expression	expression	NOUN
dti-1314	199	14	and	and	CCONJ
dti-1314	199	15	were	be	AUX
dti-1314	199	16	selected	select	VERB
dti-1314	199	17	to	to	PART
dti-1314	199	18	study	study	VERB
dti-1314	199	19	the	the	DET
dti-1314	199	20	growth	growth	NOUN
dti-1314	199	21	inhibitory	inhibitory	ADJ
dti-1314	199	22	effect	effect	NOUN
dti-1314	199	23	of	of	ADP
dti-1314	199	24	adi	adi	NOUN
dti-1314	199	25	-	-	PUNCT
dti-1314	199	26	peg20	peg20	NOUN
dti-1314	199	27	.	.	PUNCT
dti-1314	200	1	126	126	NUM
dti-1314	200	2	savaraj	savaraj	VERB
dti-1314	200	3	et	et	PROPN
dti-1314	200	4	al	al	PROPN
dti-1314	200	5	drug	drug	PROPN
dti-1314	200	6	target	target	NOUN
dti-1314	200	7	insights	insight	NOUN
dti-1314	200	8	2007	2007	NUM
dti-1314	200	9	:	:	PUNCT
dti-1314	200	10	2	2	NUM
dti-1314	200	11	currently	currently	ADV
dti-1314	200	12	investigating	investigate	VERB
dti-1314	200	13	both	both	PRON
dti-1314	200	14	transcription	transcription	NOUN
dti-1314	200	15	and	and	CCONJ
dti-1314	200	16	translation	translation	NOUN
dti-1314	200	17	control	control	NOUN
dti-1314	200	18	of	of	ADP
dti-1314	200	19	ass	ass	NOUN
dti-1314	200	20	in	in	ADP
dti-1314	200	21	both	both	CCONJ
dti-1314	200	22	normal	normal	ADJ
dti-1314	200	23	and	and	CCONJ
dti-1314	200	24	arginine	arginine	VERB
dti-1314	200	25	free	free	ADJ
dti-1314	200	26	media	medium	NOUN
dti-1314	200	27	.	.	PUNCT
dti-1314	201	1	interestingly	interestingly	ADV
dti-1314	201	2	,	,	PUNCT
dti-1314	201	3	the	the	DET
dti-1314	201	4	levels	level	NOUN
dti-1314	201	5	of	of	ADP
dti-1314	201	6	induction	induction	NOUN
dti-1314	201	7	are	be	AUX
dti-1314	201	8	different	different	ADJ
dti-1314	201	9	among	among	ADP
dti-1314	201	10	the	the	DET
dti-1314	201	11	melanoma	melanoma	NOUN
dti-1314	201	12	cell	cell	NOUN
dti-1314	201	13	lines	line	NOUN
dti-1314	201	14	tested	test	VERB
dti-1314	201	15	.	.	PUNCT
dti-1314	202	1	it	it	PRON
dti-1314	202	2	appears	appear	VERB
dti-1314	202	3	that	that	SCONJ
dti-1314	202	4	the	the	DET
dti-1314	202	5	cell	cell	NOUN
dti-1314	202	6	line	line	NOUN
dti-1314	202	7	which	which	PRON
dti-1314	202	8	has	have	VERB
dti-1314	202	9	high	high	ADJ
dti-1314	202	10	levels	level	NOUN
dti-1314	202	11	of	of	ADP
dti-1314	202	12	induction	induction	NOUN
dti-1314	202	13	is	be	AUX
dti-1314	202	14	capable	capable	ADJ
dti-1314	202	15	of	of	ADP
dti-1314	202	16	becoming	become	VERB
dti-1314	202	17	resistant	resistant	ADJ
dti-1314	202	18	to	to	ADP
dti-1314	202	19	adi	adi	PROPN
dti-1314	202	20	-eg20	-eg20	PROPN
dti-1314	202	21	in	in	ADP
dti-1314	202	22	a	a	DET
dti-1314	202	23	short	short	ADJ
dti-1314	202	24	period	period	NOUN
dti-1314	202	25	of	of	ADP
dti-1314	202	26	time	time	NOUN
dti-1314	202	27	(	(	PUNCT
dti-1314	202	28	within	within	ADP
dti-1314	202	29	6	6	NUM
dti-1314	202	30	weeks	week	NOUN
dti-1314	202	31	)	)	PUNCT
dti-1314	202	32	.	.	PUNCT
dti-1314	203	1	on	on	ADP
dti-1314	203	2	the	the	DET
dti-1314	203	3	other	other	ADJ
dti-1314	203	4	hand	hand	NOUN
dti-1314	203	5	,	,	PUNCT
dti-1314	203	6	the	the	DET
dti-1314	203	7	cell	cell	NOUN
dti-1314	203	8	line	line	NOUN
dti-1314	203	9	which	which	PRON
dti-1314	203	10	has	have	VERB
dti-1314	203	11	no	no	DET
dti-1314	203	12	induction	induction	NOUN
dti-1314	203	13	of	of	ADP
dti-1314	203	14	ass	ass	NOUN
dti-1314	203	15	(	(	PUNCT
dti-1314	203	16	mel-1220	mel-1220	NOUN
dti-1314	203	17	)	)	PUNCT
dti-1314	203	18	is	be	AUX
dti-1314	203	19	not	not	PART
dti-1314	203	20	capable	capable	ADJ
dti-1314	203	21	of	of	ADP
dti-1314	203	22	turning	turn	VERB
dti-1314	203	23	on	on	ADP
dti-1314	203	24	ass	ass	NOUN
dti-1314	203	25	gene	gene	NOUN
dti-1314	203	26	transcription	transcription	NOUN
dti-1314	203	27	and	and	CCONJ
dti-1314	203	28	becoming	become	VERB
dti-1314	203	29	resistant	resistant	ADJ
dti-1314	203	30	to	to	ADP
dti-1314	203	31	adi	adi	NOUN
dti-1314	203	32	-	-	PUNCT
dti-1314	203	33	peg20	peg20	NOUN
dti-1314	203	34	.	.	PUNCT
dti-1314	204	1	whether	whether	SCONJ
dti-1314	204	2	these	these	DET
dti-1314	204	3	fi	fi	NOUN
dti-1314	204	4	ndings	nding	NOUN
dti-1314	204	5	occur	occur	VERB
dti-1314	204	6	in	in	ADP
dti-1314	204	7	patients	patient	NOUN
dti-1314	204	8	’	'	PUNCT
dti-1314	204	9	tumor	tumor	NOUN
dti-1314	204	10	samples	sample	NOUN
dti-1314	204	11	is	be	AUX
dti-1314	204	12	not	not	PART
dti-1314	204	13	known	know	VERB
dti-1314	204	14	.	.	PUNCT
dti-1314	205	1	however	however	ADV
dti-1314	205	2	,	,	PUNCT
dti-1314	205	3	we	we	PRON
dti-1314	205	4	have	have	AUX
dti-1314	205	5	observed	observe	VERB
dti-1314	205	6	a	a	DET
dti-1314	205	7	melanoma	melanoma	NOUN
dti-1314	205	8	patient	patient	NOUN
dti-1314	205	9	who	who	PRON
dti-1314	205	10	was	be	AUX
dti-1314	205	11	ass(-	ass(-	VERB
dti-1314	205	12	)	)	PUNCT
dti-1314	205	13	prior	prior	ADV
dti-1314	205	14	to	to	ADP
dti-1314	205	15	treatment	treatment	NOUN
dti-1314	205	16	and	and	CCONJ
dti-1314	205	17	become	become	VERB
dti-1314	205	18	ass	ass	NOUN
dti-1314	205	19	positive	positive	ADJ
dti-1314	205	20	at	at	ADP
dti-1314	205	21	the	the	DET
dti-1314	205	22	time	time	NOUN
dti-1314	205	23	of	of	ADP
dti-1314	205	24	treatment	treatment	NOUN
dti-1314	205	25	failure	failure	NOUN
dti-1314	205	26	which	which	PRON
dti-1314	205	27	suggest	suggest	VERB
dti-1314	205	28	that	that	SCONJ
dti-1314	205	29	arginine	arginine	NOUN
dti-1314	205	30	deprivation	deprivation	NOUN
dti-1314	205	31	can	can	AUX
dti-1314	205	32	result	result	VERB
dti-1314	205	33	in	in	ADP
dti-1314	205	34	ass	ass	NOUN
dti-1314	205	35	expression	expression	NOUN
dti-1314	205	36	.	.	PUNCT
dti-1314	206	1	as	as	ADP
dti-1314	206	2	mention	mention	VERB
dti-1314	206	3	earlier	early	ADV
dti-1314	206	4	,	,	PUNCT
dti-1314	206	5	the	the	DET
dti-1314	206	6	mechanism	mechanism	NOUN
dti-1314	206	7	by	by	ADP
dti-1314	206	8	which	which	PRON
dti-1314	206	9	arginine	arginine	NOUN
dti-1314	206	10	in	in	ADP
dti-1314	206	11	the	the	DET
dti-1314	206	12	media	medium	NOUN
dti-1314	206	13	control	control	NOUN
dti-1314	206	14	ass	ass	NOUN
dti-1314	206	15	expression	expression	NOUN
dti-1314	206	16	is	be	AUX
dti-1314	206	17	not	not	PART
dti-1314	206	18	known	know	VERB
dti-1314	206	19	,	,	PUNCT
dti-1314	206	20	we	we	PRON
dti-1314	206	21	are	be	AUX
dti-1314	206	22	currently	currently	ADV
dti-1314	206	23	investigating	investigate	VERB
dti-1314	206	24	how	how	SCONJ
dti-1314	206	25	ass	ass	NOUN
dti-1314	206	26	gene	gene	NOUN
dti-1314	206	27	transcription	transcription	NOUN
dti-1314	206	28	is	be	AUX
dti-1314	206	29	regulated	regulate	VERB
dti-1314	206	30	in	in	ADP
dti-1314	206	31	the	the	DET
dti-1314	206	32	presence	presence	NOUN
dti-1314	206	33	and	and	CCONJ
dti-1314	206	34	absence	absence	NOUN
dti-1314	206	35	of	of	ADP
dti-1314	206	36	arginine	arginine	NOUN
dti-1314	206	37	.	.	PUNCT
dti-1314	207	1	ass	ass	NOUN
dti-1314	207	2	cdna	cdna	PROPN
dti-1314	207	3	has	have	AUX
dti-1314	207	4	been	be	AUX
dti-1314	207	5	cloned	clone	VERB
dti-1314	207	6	in	in	ADP
dti-1314	207	7	1981	1981	NUM
dti-1314	207	8	(	(	PUNCT
dti-1314	207	9	su	su	PROPN
dti-1314	207	10	et	et	PROPN
dti-1314	207	11	al	al	PROPN
dti-1314	207	12	.	.	PROPN
dti-1314	207	13	1981	1981	NUM
dti-1314	207	14	)	)	PUNCT
dti-1314	207	15	.	.	PUNCT
dti-1314	208	1	the	the	DET
dti-1314	208	2	kinetic	kinetic	ADJ
dti-1314	208	3	properties	property	NOUN
dti-1314	208	4	of	of	ADP
dti-1314	208	5	ass	ass	NOUN
dti-1314	208	6	enzyme	enzyme	NOUN
dti-1314	208	7	has	have	AUX
dti-1314	208	8	been	be	AUX
dti-1314	208	9	extensively	extensively	ADV
dti-1314	208	10	studied	study	VERB
dti-1314	208	11	and	and	CCONJ
dti-1314	208	12	the	the	DET
dti-1314	208	13	crystal	crystal	NOUN
dti-1314	208	14	structure	structure	NOUN
dti-1314	208	15	in	in	ADP
dti-1314	208	16	bacteria	bacteria	NOUN
dti-1314	208	17	has	have	AUX
dti-1314	208	18	been	be	AUX
dti-1314	208	19	identifi	identifi	PROPN
dti-1314	208	20	ed	ed	PROPN
dti-1314	208	21	(	(	PUNCT
dti-1314	208	22	husson	husson	NOUN
dti-1314	208	23	et	et	PROPN
dti-1314	208	24	al	al	PROPN
dti-1314	208	25	.	.	PROPN
dti-1314	208	26	2003	2003	NUM
dti-1314	208	27	;	;	PUNCT
dti-1314	208	28	ratner	ratner	PROPN
dti-1314	208	29	,	,	PUNCT
dti-1314	208	30	1973	1973	NUM
dti-1314	208	31	)	)	PUNCT
dti-1314	208	32	.	.	PUNCT
dti-1314	209	1	the	the	DET
dti-1314	209	2	transcriptional	transcriptional	ADJ
dti-1314	209	3	and	and	CCONJ
dti-1314	209	4	translational	translational	ADJ
dti-1314	209	5	control	control	NOUN
dti-1314	209	6	of	of	ADP
dti-1314	209	7	ass	ass	NOUN
dti-1314	209	8	gene	gene	NOUN
dti-1314	209	9	are	be	AUX
dti-1314	209	10	not	not	PART
dti-1314	209	11	well	well	ADV
dti-1314	209	12	understood	understand	VERB
dti-1314	209	13	and	and	CCONJ
dti-1314	209	14	appear	appear	VERB
dti-1314	209	15	to	to	PART
dti-1314	209	16	be	be	AUX
dti-1314	209	17	tissue	tissue	NOUN
dti-1314	209	18	specifi	specifi	X
dti-1314	209	19	c	c	PROPN
dti-1314	209	20	(	(	PUNCT
dti-1314	209	21	husson	husson	NOUN
dti-1314	209	22	et	et	PROPN
dti-1314	209	23	al	al	PROPN
dti-1314	209	24	.	.	PROPN
dti-1314	209	25	2003	2003	NUM
dti-1314	209	26	)	)	PUNCT
dti-1314	209	27	.	.	PUNCT
dti-1314	210	1	several	several	ADJ
dti-1314	210	2	hormones	hormone	NOUN
dti-1314	210	3	such	such	ADJ
dti-1314	210	4	as	as	ADP
dti-1314	210	5	glucocorticoids	glucocorticoid	NOUN
dti-1314	210	6	,	,	PUNCT
dti-1314	210	7	glucagons	glucagon	NOUN
dti-1314	210	8	,	,	PUNCT
dti-1314	210	9	insulin	insulin	NOUN
dti-1314	210	10	and	and	CCONJ
dti-1314	210	11	fatty	fatty	NOUN
dti-1314	210	12	acid	acid	NOUN
dti-1314	210	13	have	have	AUX
dti-1314	210	14	been	be	AUX
dti-1314	210	15	shown	show	VERB
dti-1314	210	16	to	to	PART
dti-1314	210	17	positively	positively	ADV
dti-1314	210	18	or	or	CCONJ
dti-1314	210	19	negatively	negatively	ADV
dti-1314	210	20	infl	infl	PROPN
dti-1314	210	21	uence	uence	NOUN
dti-1314	210	22	ass	ass	NOUN
dti-1314	210	23	expression	expression	NOUN
dti-1314	210	24	(	(	PUNCT
dti-1314	210	25	husson	husson	NOUN
dti-1314	210	26	et	et	PROPN
dti-1314	210	27	al	al	PROPN
dti-1314	210	28	.	.	PROPN
dti-1314	210	29	1975	1975	NUM
dti-1314	210	30	;	;	PUNCT
dti-1314	210	31	husson	husson	NOUN
dti-1314	210	32	et	et	PROPN
dti-1314	210	33	al	al	PROPN
dti-1314	210	34	.	.	PROPN
dti-1314	210	35	1986	1986	NUM
dti-1314	210	36	;	;	PUNCT
dti-1314	210	37	husson	husson	NOUN
dti-1314	210	38	and	and	CCONJ
dti-1314	210	39	vaillant	vaillant	NOUN
dti-1314	210	40	,	,	PUNCT
dti-1314	210	41	1979	1979	NUM
dti-1314	210	42	;	;	PUNCT
dti-1314	210	43	husson	husson	NOUN
dti-1314	210	44	and	and	CCONJ
dti-1314	210	45	vaillant	vaillant	NOUN
dti-1314	210	46	,	,	PUNCT
dti-1314	210	47	1982	1982	NUM
dti-1314	210	48	;	;	PUNCT
dti-1314	210	49	lin	lin	PROPN
dti-1314	210	50	et	et	PROPN
dti-1314	210	51	al	al	PROPN
dti-1314	210	52	.	.	PROPN
dti-1314	210	53	1982	1982	NUM
dti-1314	210	54	)	)	PUNCT
dti-1314	210	55	.	.	PUNCT
dti-1314	211	1	our	our	PRON
dti-1314	211	2	preliminary	preliminary	ADJ
dti-1314	211	3	data	datum	NOUN
dti-1314	211	4	does	do	AUX
dti-1314	211	5	not	not	PART
dti-1314	211	6	indicate	indicate	VERB
dti-1314	211	7	that	that	SCONJ
dti-1314	211	8	these	these	DET
dti-1314	211	9	hormones	hormone	NOUN
dti-1314	211	10	infl	infl	PROPN
dti-1314	211	11	uence	uence	NOUN
dti-1314	211	12	ass	ass	NOUN
dti-1314	211	13	expression	expression	NOUN
dti-1314	211	14	in	in	ADP
dti-1314	211	15	melanoma	melanoma	NOUN
dti-1314	211	16	cells	cell	NOUN
dti-1314	211	17	.	.	PUNCT
dti-1314	212	1	however	however	ADV
dti-1314	212	2	,	,	PUNCT
dti-1314	212	3	arginine	arginine	NOUN
dti-1314	212	4	in	in	ADP
dti-1314	212	5	the	the	DET
dti-1314	212	6	media	medium	NOUN
dti-1314	212	7	can	can	AUX
dti-1314	212	8	mediate	mediate	VERB
dti-1314	212	9	ass	ass	NOUN
dti-1314	212	10	expression	expression	NOUN
dti-1314	212	11	in	in	ADP
dti-1314	212	12	certain	certain	ADJ
dti-1314	212	13	melanoma	melanoma	NOUN
dti-1314	212	14	cells	cell	NOUN
dti-1314	212	15	.	.	PUNCT
dti-1314	213	1	in	in	ADP
dti-1314	213	2	contrast	contrast	NOUN
dti-1314	213	3	,	,	PUNCT
dti-1314	213	4	arginine	arginine	NOUN
dti-1314	213	5	in	in	ADP
dti-1314	213	6	the	the	DET
dti-1314	213	7	media	medium	NOUN
dti-1314	213	8	has	have	VERB
dti-1314	213	9	no	no	DET
dti-1314	213	10	effect	effect	NOUN
dti-1314	213	11	in	in	ADP
dti-1314	213	12	a2058r	a2058r	PROPN
dti-1314	213	13	(	(	PUNCT
dti-1314	213	14	selected	select	VERB
dti-1314	213	15	by	by	ADP
dti-1314	213	16	adi	adi	PROPN
dti-1314	213	17	-	-	PUNCT
dti-1314	213	18	peg20	peg20	PROPN
dti-1314	213	19	)	)	PUNCT
dti-1314	213	20	or	or	CCONJ
dti-1314	213	21	nsclcs	nsclcs	NOUN
dti-1314	213	22	,	,	PUNCT
dti-1314	213	23	both	both	PRON
dti-1314	213	24	have	have	VERB
dti-1314	213	25	high	high	ADJ
dti-1314	213	26	levels	level	NOUN
dti-1314	213	27	of	of	ADP
dti-1314	213	28	ass	ass	NOUN
dti-1314	213	29	expression	expression	NOUN
dti-1314	213	30	.	.	PUNCT
dti-1314	214	1	this	this	DET
dti-1314	214	2	fi	fi	NOUN
dti-1314	214	3	nding	nde	VERB
dti-1314	214	4	is	be	AUX
dti-1314	214	5	similar	similar	ADJ
dti-1314	214	6	to	to	ADP
dti-1314	214	7	the	the	DET
dti-1314	214	8	previous	previous	ADJ
dti-1314	214	9	report	report	NOUN
dti-1314	214	10	(	(	PUNCT
dti-1314	214	11	boyce	boyce	PROPN
dti-1314	214	12	et	et	PROPN
dti-1314	214	13	al	al	PROPN
dti-1314	214	14	.	.	PROPN
dti-1314	214	15	1986	1986	NUM
dti-1314	214	16	)	)	PUNCT
dti-1314	214	17	which	which	PRON
dti-1314	214	18	showed	show	VERB
dti-1314	214	19	that	that	PRON
dti-1314	214	20	arginine	arginine	NOUN
dti-1314	214	21	mediated	mediate	VERB
dti-1314	214	22	ass	ass	NOUN
dti-1314	214	23	repression	repression	NOUN
dti-1314	214	24	does	do	AUX
dti-1314	214	25	not	not	PART
dti-1314	214	26	occur	occur	VERB
dti-1314	214	27	in	in	ADP
dti-1314	214	28	canavanine	canavanine	NOUN
dti-1314	214	29	(	(	PUNCT
dti-1314	214	30	arginine	arginine	NOUN
dti-1314	214	31	analog	analog	NOUN
dti-1314	214	32	)	)	PUNCT
dti-1314	214	33	resistant	resistant	ADJ
dti-1314	214	34	variant	variant	NOUN
dti-1314	214	35	of	of	ADP
dti-1314	214	36	rpmi	rpmi	NOUN
dti-1314	214	37	2650	2650	NUM
dti-1314	214	38	cells	cell	NOUN
dti-1314	214	39	which	which	PRON
dti-1314	214	40	has	have	VERB
dti-1314	214	41	high	high	ADJ
dti-1314	214	42	levels	level	NOUN
dti-1314	214	43	of	of	ADP
dti-1314	214	44	ass	ass	NOUN
dti-1314	214	45	expression	expression	NOUN
dti-1314	214	46	.	.	PUNCT
dti-1314	215	1	ass	ass	NOUN
dti-1314	215	2	actin	actin	NOUN
dti-1314	215	3	a	a	DET
dti-1314	215	4	37	37	NUM
dti-1314	215	5	5	5	NUM
dti-1314	215	6	a	a	DET
dti-1314	215	7	37	37	NUM
dti-1314	215	8	5	5	NUM
dti-1314	215	9	+	+	CCONJ
dti-1314	216	1	a	a	PRON
dti-1314	216	2	d	d	X
dti-1314	217	1	i	i	PRON
dti-1314	217	2	s	s	VERB
dti-1314	217	3	km	km	PROPN
dti-1314	218	1	el	el	PROPN
dti-1314	218	2	-2	-2	PROPN
dti-1314	218	3	s	s	PROPN
dti-1314	219	1	km	km	PROPN
dti-1314	219	2	el	el	PROPN
dti-1314	219	3	-2	-2	INTJ
dti-1314	220	1	+	+	NOUN
dti-1314	220	2	a	a	X
dti-1314	220	3	d	d	NOUN
dti-1314	220	4	i	i	PRON
dti-1314	220	5	m	m	VERB
dti-1314	220	6	el	el	PROPN
dti-1314	220	7	-1	-1	PROPN
dti-1314	221	1	22	22	NUM
dti-1314	221	2	0	0	NUM
dti-1314	221	3	m	m	VERB
dti-1314	222	1	el	el	NOUN
dti-1314	222	2	-1	-1	PROPN
dti-1314	222	3	22	22	NUM
dti-1314	222	4	0	0	NUM
dti-1314	222	5	+	+	NUM
dti-1314	222	6	ad	ad	NOUN
dti-1314	222	7	i	i	NOUN
dti-1314	222	8	a2	a2	VERB
dti-1314	222	9	05	05	NUM
dti-1314	222	10	8	8	NUM
dti-1314	222	11	a	a	DET
dti-1314	222	12	20	20	NUM
dti-1314	222	13	58	58	NUM
dti-1314	223	1	+	+	NOUN
dti-1314	223	2	a	a	PRON
dti-1314	223	3	d	d	X
dti-1314	223	4	i	i	PROPN
dti-1314	223	5	a2	a2	PROPN
dti-1314	223	6	05	05	NUM
dti-1314	223	7	8r	8r	PROPN
dti-1314	223	8	b	b	PROPN
dti-1314	223	9	j1	j1	PROPN
dti-1314	223	10	b	b	PROPN
dti-1314	223	11	j1	j1	PROPN
dti-1314	223	12	+	+	CCONJ
dti-1314	223	13	a	a	PROPN
dti-1314	223	14	d	d	NOUN
dti-1314	223	15	i	i	PRON
dti-1314	223	16	figure	figure	VERB
dti-1314	223	17	8a	8a	NUM
dti-1314	223	18	.	.	PUNCT
dti-1314	224	1	northernblot	northernblot	ADJ
dti-1314	224	2	analysis	analysis	NOUN
dti-1314	224	3	of	of	ADP
dti-1314	224	4	ass	ass	NOUN
dti-1314	224	5	in	in	ADP
dti-1314	224	6	a	a	DET
dti-1314	224	7	panel	panel	NOUN
dti-1314	224	8	of	of	ADP
dti-1314	224	9	melanoma	melanoma	NOUN
dti-1314	224	10	cell	cell	NOUN
dti-1314	224	11	line	line	NOUN
dti-1314	224	12	and	and	CCONJ
dti-1314	224	13	bj-1	bj-1	ADV
dti-1314	224	14	cells	cell	NOUN
dti-1314	224	15	.	.	PUNCT
dti-1314	225	1	lane	lane	NOUN
dti-1314	225	2	1	1	NUM
dti-1314	225	3	:	:	PUNCT
dti-1314	225	4	a375	a375	PROPN
dti-1314	225	5	.	.	PUNCT
dti-1314	225	6	lane	lane	NOUN
dti-1314	225	7	2	2	NUM
dti-1314	225	8	:	:	PUNCT
dti-1314	225	9	a375	a375	PROPN
dti-1314	225	10	after	after	ADP
dti-1314	225	11	exposure	exposure	NOUN
dti-1314	225	12	to	to	ADP
dti-1314	225	13	adi	adi	NOUN
dti-1314	225	14	-	-	PUNCT
dti-1314	225	15	peg20	peg20	PROPN
dti-1314	225	16	for	for	ADP
dti-1314	225	17	72hrs	72hrs	PROPN
dti-1314	225	18	.	.	PUNCT
dti-1314	226	1	lane	lane	PROPN
dti-1314	226	2	3	3	NUM
dti-1314	226	3	:	:	PUNCT
dti-1314	226	4	sk	sk	NOUN
dti-1314	226	5	-	-	PUNCT
dti-1314	226	6	mel-2	mel-2	PUNCT
dti-1314	226	7	lane	lane	NOUN
dti-1314	226	8	4	4	NUM
dti-1314	226	9	:	:	PUNCT
dti-1314	226	10	sk	sk	NOUN
dti-1314	226	11	-	-	PUNCT
dti-1314	226	12	mel-2	mel-2	PUNCT
dti-1314	226	13	after	after	ADP
dti-1314	226	14	exposure	exposure	NOUN
dti-1314	226	15	to	to	ADP
dti-1314	226	16	adi	adi	NOUN
dti-1314	226	17	-	-	PUNCT
dti-1314	226	18	peg20	peg20	PROPN
dti-1314	226	19	for	for	ADP
dti-1314	226	20	72	72	NUM
dti-1314	226	21	hrs	hrs	NOUN
dti-1314	226	22	.	.	PUNCT
dti-1314	227	1	lane	lane	NOUN
dti-1314	227	2	5	5	NUM
dti-1314	227	3	:	:	PUNCT
dti-1314	227	4	mel-1220	mel-1220	NOUN
dti-1314	227	5	.	.	PUNCT
dti-1314	228	1	lane	lane	PROPN
dti-1314	228	2	6	6	NUM
dti-1314	228	3	:	:	PUNCT
dti-1314	228	4	mel-1220	mel-1220	NOUN
dti-1314	228	5	after	after	ADP
dti-1314	228	6	exposure	exposure	NOUN
dti-1314	228	7	to	to	ADP
dti-1314	228	8	adi	adi	NOUN
dti-1314	228	9	-	-	PUNCT
dti-1314	228	10	peg20	peg20	PROPN
dti-1314	228	11	for	for	ADP
dti-1314	228	12	72	72	NUM
dti-1314	228	13	hrs	hrs	NOUN
dti-1314	228	14	.	.	PUNCT
dti-1314	229	1	lane	lane	NOUN
dti-1314	229	2	7	7	NUM
dti-1314	229	3	:	:	PUNCT
dti-1314	229	4	a2058	a2058	PROPN
dti-1314	229	5	.	.	NOUN
dti-1314	229	6	lane	lane	NOUN
dti-1314	229	7	8	8	NUM
dti-1314	229	8	:	:	PUNCT
dti-1314	229	9	a2058	a2058	ADP
dti-1314	229	10	after	after	ADP
dti-1314	229	11	exposure	exposure	NOUN
dti-1314	229	12	to	to	ADP
dti-1314	229	13	adi	adi	NOUN
dti-1314	229	14	-	-	PUNCT
dti-1314	229	15	peg20	peg20	PROPN
dti-1314	229	16	for	for	ADP
dti-1314	229	17	72	72	NUM
dti-1314	229	18	hrs	hrs	NOUN
dti-1314	229	19	.	.	PUNCT
dti-1314	230	1	lane	lane	NOUN
dti-1314	230	2	9	9	NUM
dti-1314	230	3	:	:	PUNCT
dti-1314	230	4	a2058r	a2058r	ADJ
dti-1314	230	5	.	.	PROPN
dti-1314	230	6	lane	lane	PROPN
dti-1314	230	7	10	10	NUM
dti-1314	230	8	:	:	PUNCT
dti-1314	230	9	bj-1	bj-1	NOUN
dti-1314	230	10	.	.	PUNCT
dti-1314	231	1	lane	lane	PROPN
dti-1314	231	2	11	11	NUM
dti-1314	231	3	:	:	PUNCT
dti-1314	231	4	bj-1	bj-1	ADV
dti-1314	231	5	after	after	ADP
dti-1314	231	6	exposure	exposure	NOUN
dti-1314	231	7	to	to	ADP
dti-1314	231	8	adi	adi	NOUN
dti-1314	231	9	-	-	PUNCT
dti-1314	231	10	peg20	peg20	PROPN
dti-1314	231	11	for	for	ADP
dti-1314	231	12	72	72	NUM
dti-1314	231	13	hrs	hrs	NOUN
dti-1314	231	14	.	.	PUNCT
dti-1314	232	1	note	note	NOUN
dti-1314	232	2	:	:	PUNCT
dti-1314	232	3	only	only	ADV
dti-1314	232	4	a2058r	a2058r	PROPN
dti-1314	232	5	and	and	CCONJ
dti-1314	232	6	bj-1	bj-1	ADV
dti-1314	232	7	possess	possess	VERB
dti-1314	232	8	1.9	1.9	NUM
dti-1314	232	9	kb	kb	PROPN
dti-1314	232	10	ass	ass	NOUN
dti-1314	232	11	mrna	mrna	NOUN
dti-1314	232	12	and	and	CCONJ
dti-1314	232	13	there	there	PRON
dti-1314	232	14	is	be	VERB
dti-1314	232	15	no	no	DET
dti-1314	232	16	differences	difference	NOUN
dti-1314	232	17	in	in	ADP
dti-1314	232	18	ass	ass	PROPN
dti-1314	232	19	mrna	mrna	NOUN
dti-1314	232	20	in	in	ADP
dti-1314	232	21	bj-1	bj-1	PRON
dti-1314	232	22	cells	cell	NOUN
dti-1314	232	23	after	after	ADP
dti-1314	232	24	exposure	exposure	NOUN
dti-1314	232	25	to	to	ADP
dti-1314	232	26	adi	adi	PROPN
dti-1314	232	27	-	-	PUNCT
dti-1314	232	28	peg20	peg20	NOUN
dti-1314	232	29	.	.	PUNCT
dti-1314	233	1	1	1	NUM
dti-1314	233	2	2	2	NUM
dti-1314	233	3	3	3	NUM
dti-1314	233	4	4	4	NUM
dti-1314	233	5	5	5	NUM
dti-1314	233	6	ass	ass	NOUN
dti-1314	233	7	actin	actin	NOUN
dti-1314	233	8	figure	figure	NOUN
dti-1314	233	9	8b	8b	NUM
dti-1314	233	10	.	.	PUNCT
dti-1314	234	1	immunoblot	immunoblot	NOUN
dti-1314	234	2	of	of	ADP
dti-1314	234	3	ass	ass	PROPN
dti-1314	234	4	.	.	PUNCT
dti-1314	235	1	lane	lane	PROPN
dti-1314	235	2	1	1	NUM
dti-1314	235	3	:	:	PUNCT
dti-1314	235	4	a2058	a2058	PROPN
dti-1314	235	5	.	.	PROPN
dti-1314	235	6	lane	lane	NOUN
dti-1314	235	7	2	2	NUM
dti-1314	235	8	:	:	PUNCT
dti-1314	235	9	a2058	a2058	NUM
dti-1314	235	10	in	in	ADP
dti-1314	235	11	arginine	arginine	NOUN
dti-1314	235	12	free	free	ADJ
dti-1314	235	13	media	medium	NOUN
dti-1314	235	14	with	with	ADP
dti-1314	235	15	out	out	ADP
dti-1314	235	16	citrulline	citrulline	NOUN
dti-1314	235	17	and	and	CCONJ
dti-1314	235	18	nh4cl2	nh4cl2	PROPN
dti-1314	235	19	.	.	PUNCT
dti-1314	236	1	lane	lane	PROPN
dti-1314	236	2	3	3	NUM
dti-1314	236	3	:	:	PUNCT
dti-1314	236	4	a2058	a2058	NUM
dti-1314	236	5	in	in	ADP
dti-1314	236	6	arginine	arginine	NOUN
dti-1314	236	7	free	free	ADJ
dti-1314	236	8	media	medium	NOUN
dti-1314	236	9	supplemented	supplement	VERB
dti-1314	236	10	with	with	ADP
dti-1314	236	11	citrulline	citrulline	NOUN
dti-1314	236	12	and	and	CCONJ
dti-1314	236	13	nh4cl	nh4cl	PROPN
dti-1314	236	14	.	.	PUNCT
dti-1314	237	1	lane	lane	PROPN
dti-1314	237	2	4	4	NUM
dti-1314	237	3	:	:	PUNCT
dti-1314	237	4	a2058r	a2058r	PROPN
dti-1314	237	5	.	.	PROPN
dti-1314	237	6	lane	lane	PROPN
dti-1314	237	7	5	5	NUM
dti-1314	237	8	:	:	PUNCT
dti-1314	237	9	bj-1	bj-1	ADV
dti-1314	237	10	cells	cell	NOUN
dti-1314	237	11	.	.	PUNCT
dti-1314	238	1	ass	ass	NOUN
dti-1314	238	2	protein	protein	NOUN
dti-1314	238	3	in	in	ADP
dti-1314	238	4	a2058r	a2058r	PROPN
dti-1314	238	5	is	be	AUX
dti-1314	238	6	only	only	ADV
dti-1314	238	7	slightly	slightly	ADV
dti-1314	238	8	less	less	ADJ
dti-1314	238	9	than	than	ADP
dti-1314	238	10	bj-1	bj-1	VERB
dti-1314	238	11	.	.	PUNCT
dti-1314	239	1	127	127	NUM
dti-1314	239	2	argininosuccinate	argininosuccinate	NOUN
dti-1314	239	3	synthetase	synthetase	NOUN
dti-1314	239	4	in	in	ADP
dti-1314	239	5	melanoma	melanoma	NOUN
dti-1314	239	6	drug	drug	NOUN
dti-1314	239	7	target	target	NOUN
dti-1314	239	8	insights	insight	NOUN
dti-1314	239	9	2007	2007	NUM
dti-1314	239	10	:	:	PUNCT
dti-1314	239	11	2	2	NUM
dti-1314	239	12	nevertheless	nevertheless	ADV
dti-1314	239	13	,	,	PUNCT
dti-1314	239	14	the	the	DET
dti-1314	239	15	key	key	ADJ
dti-1314	239	16	question	question	NOUN
dti-1314	239	17	remains	remain	VERB
dti-1314	239	18	what	what	PRON
dti-1314	239	19	are	be	AUX
dti-1314	239	20	the	the	DET
dti-1314	239	21	factors	factor	NOUN
dti-1314	239	22	which	which	PRON
dti-1314	239	23	govern	govern	VERB
dti-1314	239	24	ass	ass	NOUN
dti-1314	239	25	expression	expression	NOUN
dti-1314	239	26	in	in	ADP
dti-1314	239	27	melanoma	melanoma	NOUN
dti-1314	239	28	cells	cell	NOUN
dti-1314	239	29	.	.	PUNCT
dti-1314	240	1	if	if	SCONJ
dti-1314	240	2	these	these	DET
dti-1314	240	3	factors	factor	NOUN
dti-1314	240	4	can	can	AUX
dti-1314	240	5	be	be	AUX
dti-1314	240	6	identifi	identifi	PROPN
dti-1314	240	7	ed	ed	NOUN
dti-1314	240	8	,	,	PUNCT
dti-1314	240	9	one	one	PRON
dti-1314	240	10	can	can	AUX
dti-1314	240	11	attempt	attempt	VERB
dti-1314	240	12	to	to	PART
dti-1314	240	13	repress	repress	VERB
dti-1314	240	14	the	the	DET
dti-1314	240	15	ass	ass	NOUN
dti-1314	240	16	expression	expression	NOUN
dti-1314	240	17	and	and	CCONJ
dti-1314	240	18	hence	hence	ADV
dti-1314	240	19	evade	evade	VERB
dti-1314	240	20	adi	adi	NOUN
dti-1314	240	21	-	-	PUNCT
dti-1314	240	22	peg20	peg20	PROPN
dti-1314	240	23	resistance	resistance	NOUN
dti-1314	240	24	.	.	PUNCT
dti-1314	241	1	it	it	PRON
dti-1314	241	2	is	be	AUX
dti-1314	241	3	not	not	PART
dti-1314	241	4	yet	yet	ADV
dti-1314	241	5	clear	clear	ADJ
dti-1314	241	6	why	why	SCONJ
dti-1314	241	7	transfection	transfection	NOUN
dti-1314	241	8	with	with	ADP
dti-1314	241	9	ass	ass	PROPN
dti-1314	241	10	cdna	cdna	PROPN
dti-1314	241	11	in	in	ADP
dti-1314	241	12	melanoma	melanoma	NOUN
dti-1314	241	13	cells	cell	NOUN
dti-1314	241	14	did	do	AUX
dti-1314	241	15	not	not	PART
dti-1314	241	16	yield	yield	VERB
dti-1314	241	17	high	high	ADJ
dti-1314	241	18	levels	level	NOUN
dti-1314	241	19	of	of	ADP
dti-1314	241	20	ass	ass	NOUN
dti-1314	241	21	expression	expression	NOUN
dti-1314	241	22	and	and	CCONJ
dti-1314	241	23	we	we	PRON
dti-1314	241	24	are	be	AUX
dti-1314	241	25	unable	unable	ADJ
dti-1314	241	26	to	to	PART
dti-1314	241	27	generate	generate	VERB
dti-1314	241	28	stable	stable	ADJ
dti-1314	241	29	transfected	transfecte	VERB
dti-1314	241	30	cell	cell	NOUN
dti-1314	241	31	line(s	line(s	NOUN
dti-1314	241	32	)	)	PUNCT
dti-1314	241	33	.	.	PUNCT
dti-1314	242	1	it	it	PRON
dti-1314	242	2	is	be	AUX
dti-1314	242	3	conceivable	conceivable	ADJ
dti-1314	242	4	that	that	SCONJ
dti-1314	242	5	certain	certain	ADJ
dti-1314	242	6	factors	factor	NOUN
dti-1314	242	7	in	in	ADP
dti-1314	242	8	melanoma	melanoma	NOUN
dti-1314	242	9	cells	cell	NOUN
dti-1314	242	10	prevent	prevent	VERB
dti-1314	242	11	this	this	DET
dti-1314	242	12	cdna	cdna	PROPN
dti-1314	242	13	to	to	PART
dti-1314	242	14	express	express	VERB
dti-1314	242	15	at	at	ADP
dti-1314	242	16	high	high	ADJ
dti-1314	242	17	levels	level	NOUN
dti-1314	242	18	and/or	and/or	CCONJ
dti-1314	242	19	arginine	arginine	VERB
dti-1314	242	20	in	in	ADP
dti-1314	242	21	the	the	DET
dti-1314	242	22	media	medium	NOUN
dti-1314	242	23	may	may	AUX
dti-1314	242	24	also	also	ADV
dti-1314	242	25	play	play	VERB
dti-1314	242	26	a	a	DET
dti-1314	242	27	role	role	NOUN
dti-1314	242	28	in	in	ADP
dti-1314	242	29	repressing	repress	VERB
dti-1314	242	30	the	the	DET
dti-1314	242	31	expression	expression	NOUN
dti-1314	242	32	of	of	ADP
dti-1314	242	33	transfected	transfecte	VERB
dti-1314	242	34	ass	ass	NOUN
dti-1314	242	35	.	.	PUNCT
dti-1314	243	1	we	we	PRON
dti-1314	243	2	are	be	AUX
dti-1314	243	3	currently	currently	ADV
dti-1314	243	4	investigating	investigate	VERB
dti-1314	243	5	these	these	DET
dti-1314	243	6	possibilities	possibility	NOUN
dti-1314	243	7	.	.	PUNCT
dti-1314	244	1	acknowledgment	acknowledgment	NOUN
dti-1314	244	2	this	this	DET
dti-1314	244	3	work	work	NOUN
dti-1314	244	4	was	be	AUX
dti-1314	244	5	supported	support	VERB
dti-1314	244	6	by	by	ADP
dti-1314	244	7	a	a	DET
dti-1314	244	8	grant	grant	NOUN
dti-1314	244	9	(	(	PUNCT
dti-1314	244	10	r01ca	r01ca	PROPN
dti-1314	244	11	109578	109578	NUM
dti-1314	244	12	)	)	PUNCT
dti-1314	244	13	from	from	ADP
dti-1314	244	14	nih	nih	PROPN
dti-1314	244	15	and	and	CCONJ
dti-1314	244	16	a	a	DET
dti-1314	244	17	research	research	NOUN
dti-1314	244	18	grant	grant	NOUN
dti-1314	244	19	from	from	ADP
dti-1314	244	20	va	va	PROPN
dti-1314	244	21	.	.	PUNCT
dti-1314	245	1	we	we	PRON
dti-1314	245	2	would	would	AUX
dti-1314	245	3	like	like	VERB
dti-1314	245	4	to	to	PART
dti-1314	245	5	thank	thank	VERB
dti-1314	245	6	polaris	polaris	PROPN
dti-1314	245	7	inc	inc	PROPN
dti-1314	245	8	.	.	PROPN
dti-1314	245	9	for	for	ADP
dti-1314	245	10	providing	provide	VERB
dti-1314	245	11	adi	adi	PROPN
dti-1314	245	12	-	-	PUNCT
dti-1314	245	13	peg20	peg20	PROPN
dti-1314	245	14	and	and	CCONJ
dti-1314	245	15	analysis	analysis	NOUN
dti-1314	245	16	of	of	ADP
dti-1314	245	17	arginine	arginine	NOUN
dti-1314	245	18	and	and	CCONJ
dti-1314	245	19	citrulline	citrulline	NOUN
dti-1314	245	20	.	.	PUNCT
dti-1314	246	1	references	reference	NOUN
dti-1314	246	2	alsina	alsina	PROPN
dti-1314	246	3	,	,	PUNCT
dti-1314	246	4	j.	j.	PROPN
dti-1314	246	5	,	,	PUNCT
dti-1314	246	6	gorsk	gorsk	PROPN
dti-1314	246	7	,	,	PUNCT
dti-1314	246	8	d.h	d.h	PROPN
dti-1314	246	9	.	.	PROPN
dti-1314	246	10	,	,	PUNCT
dti-1314	246	11	germino	germino	PROPN
dti-1314	246	12	,	,	PUNCT
dti-1314	246	13	f.j	f.j	PROPN
dti-1314	246	14	.	.	PROPN
dti-1314	246	15	et	et	PROPN
dti-1314	246	16	al	al	PROPN
dti-1314	246	17	.	.	PROPN
dti-1314	246	18	2003	2003	NUM
dti-1314	246	19	.	.	PUNCT
dti-1314	247	1	detection	detection	NOUN
dti-1314	247	2	of	of	ADP
dti-1314	247	3	mutations	mutation	NOUN
dti-1314	247	4	in	in	ADP
dti-1314	247	5	the	the	DET
dti-1314	247	6	mitogen	mitogen	NOUN
dti-1314	247	7	-	-	PUNCT
dti-1314	247	8	activated	activate	VERB
dti-1314	247	9	protein	protein	NOUN
dti-1314	247	10	kinase	kinase	NOUN
dti-1314	247	11	pathway	pathway	NOUN
dti-1314	247	12	in	in	ADP
dti-1314	247	13	human	human	ADJ
dti-1314	247	14	melanoma	melanoma	NOUN
dti-1314	247	15	.	.	PUNCT
dti-1314	248	1	clin	clin	PROPN
dti-1314	248	2	.	.	PUNCT
dti-1314	249	1	cancer	cancer	NOUN
dti-1314	249	2	res	re	NOUN
dti-1314	249	3	.	.	PROPN
dti-1314	249	4	,	,	PUNCT
dti-1314	249	5	9:6419–25	9:6419–25	NUM
dti-1314	249	6	.	.	PUNCT
dti-1314	250	1	ascierto	ascierto	PROPN
dti-1314	250	2	,	,	PUNCT
dti-1314	250	3	p.a	p.a	PROPN
dti-1314	250	4	.	.	PROPN
dti-1314	250	5	,	,	PUNCT
dti-1314	250	6	scala	scala	PROPN
dti-1314	250	7	,	,	PUNCT
dti-1314	250	8	s.	s.	PROPN
dti-1314	250	9	,	,	PUNCT
dti-1314	250	10	castello	castello	PROPN
dti-1314	250	11	,	,	PUNCT
dti-1314	250	12	g.	g.	PROPN
dti-1314	250	13	et	et	PROPN
dti-1314	250	14	al	al	PROPN
dti-1314	250	15	.	.	PROPN
dti-1314	250	16	2005	2005	NUM
dti-1314	250	17	.	.	PUNCT
dti-1314	251	1	pegylated	pegylate	VERB
dti-1314	251	2	arginine	arginine	NOUN
dti-1314	251	3	deiminase	deiminase	VERB
dti-1314	251	4	treatment	treatment	NOUN
dti-1314	251	5	of	of	ADP
dti-1314	251	6	patients	patient	NOUN
dti-1314	251	7	with	with	ADP
dti-1314	251	8	metastatic	metastatic	ADJ
dti-1314	251	9	melanoma	melanoma	NOUN
dti-1314	251	10	:	:	PUNCT
dti-1314	251	11	results	result	NOUN
dti-1314	251	12	from	from	ADP
dti-1314	251	13	phase	phase	NOUN
dti-1314	251	14	i	i	PRON
dti-1314	251	15	and	and	CCONJ
dti-1314	251	16	ii	ii	PROPN
dti-1314	251	17	studies	study	NOUN
dti-1314	251	18	.	.	PUNCT
dti-1314	252	1	j.	j.	PROPN
dti-1314	252	2	clin	clin	PROPN
dti-1314	252	3	.	.	PUNCT
dti-1314	253	1	oncol	oncol	PROPN
dti-1314	253	2	.	.	PUNCT
dti-1314	253	3	,	,	PUNCT
dti-1314	253	4	23:7660–8	23:7660–8	X
dti-1314	253	5	.	.	PUNCT
dti-1314	254	1	boyce	boyce	PROPN
dti-1314	254	2	,	,	PUNCT
dti-1314	254	3	f.m	f.m	PROPN
dti-1314	254	4	.	.	PROPN
dti-1314	254	5	,	,	PUNCT
dti-1314	254	6	anderson	anderson	PROPN
dti-1314	254	7	,	,	PUNCT
dti-1314	254	8	g.m	g.m	PROPN
dti-1314	254	9	.	.	PROPN
dti-1314	254	10	,	,	PUNCT
dti-1314	254	11	rusk	rusk	PROPN
dti-1314	254	12	,	,	PUNCT
dti-1314	254	13	c.d	c.d	PROPN
dti-1314	254	14	.	.	PROPN
dti-1314	254	15	et	et	PROPN
dti-1314	254	16	al	al	PROPN
dti-1314	254	17	.	.	PROPN
dti-1314	254	18	1986	1986	NUM
dti-1314	254	19	.	.	PUNCT
dti-1314	255	1	human	human	ADJ
dti-1314	255	2	argininosuccinate	argininosuccinate	NOUN
dti-1314	255	3	synthetase	synthetase	NOUN
dti-1314	255	4	minigenes	minigene	NOUN
dti-1314	255	5	are	be	AUX
dti-1314	255	6	subject	subject	ADJ
dti-1314	255	7	to	to	ADP
dti-1314	255	8	arginine	arginine	NOUN
dti-1314	255	9	-	-	PUNCT
dti-1314	255	10	mediated	mediate	VERB
dti-1314	255	11	repression	repression	NOUN
dti-1314	255	12	but	but	CCONJ
dti-1314	255	13	not	not	PART
dti-1314	255	14	to	to	PART
dti-1314	255	15	trans	trans	VERB
dti-1314	255	16	induction	induction	NOUN
dti-1314	255	17	.	.	PUNCT
dti-1314	256	1	mol	mol	PROPN
dti-1314	256	2	.	.	PROPN
dti-1314	256	3	cell	cell	NOUN
dti-1314	256	4	.	.	PUNCT
dti-1314	257	1	biol	biol	PROPN
dti-1314	257	2	.	.	PUNCT
dti-1314	257	3	,	,	PUNCT
dti-1314	257	4	6:1244–52	6:1244–52	PROPN
dti-1314	257	5	.	.	PUNCT
dti-1314	258	1	brinckerhoff	brinckerhoff	PROPN
dti-1314	258	2	,	,	PUNCT
dti-1314	258	3	l.h	l.h	PROPN
dti-1314	258	4	.	.	PROPN
dti-1314	258	5	,	,	PUNCT
dti-1314	258	6	thompson	thompson	PROPN
dti-1314	258	7	,	,	PUNCT
dti-1314	258	8	l.w	l.w	PROPN
dti-1314	258	9	.	.	PROPN
dti-1314	258	10	and	and	CCONJ
dti-1314	258	11	slingluff	slingluff	PROPN
dti-1314	258	12	,	,	PUNCT
dti-1314	258	13	c.l	c.l	PROPN
dti-1314	258	14	.	.	PROPN
dti-1314	258	15	jr	jr	PROPN
dti-1314	258	16	.	.	PROPN
dti-1314	258	17	2000	2000	NUM
dti-1314	258	18	.	.	PUNCT
dti-1314	259	1	melanoma	melanoma	NOUN
dti-1314	259	2	vaccines	vaccine	NOUN
dti-1314	259	3	.	.	PUNCT
dti-1314	260	1	curr	curr	PROPN
dti-1314	260	2	.	.	PUNCT
dti-1314	261	1	opin	opin	NOUN
dti-1314	261	2	.	.	PUNCT
dti-1314	262	1	oncol	oncol	PROPN
dti-1314	262	2	.	.	PUNCT
dti-1314	262	3	,	,	PUNCT
dti-1314	262	4	12:163–73	12:163–73	PROPN
dti-1314	262	5	.	.	PUNCT
dti-1314	263	1	devita	devita	PROPN
dti-1314	263	2	,	,	PUNCT
dti-1314	263	3	v.t	v.t	PROPN
dti-1314	263	4	.	.	PROPN
dti-1314	263	5	,	,	PUNCT
dti-1314	263	6	hellman	hellman	PROPN
dti-1314	263	7	,	,	PUNCT
dti-1314	263	8	s.	s.	PROPN
dti-1314	263	9	and	and	CCONJ
dti-1314	263	10	rosenberg	rosenberg	PROPN
dti-1314	263	11	,	,	PUNCT
dti-1314	263	12	s.a	s.a	PROPN
dti-1314	263	13	.	.	PROPN
dti-1314	263	14	2001	2001	NUM
dti-1314	263	15	.	.	PUNCT
dti-1314	264	1	cancer	cancer	NOUN
dti-1314	264	2	,	,	PUNCT
dti-1314	264	3	principles	principle	NOUN
dti-1314	264	4	and	and	CCONJ
dti-1314	264	5	practice	practice	NOUN
dti-1314	264	6	of	of	ADP
dti-1314	264	7	oncology	oncology	NOUN
dti-1314	264	8	.	.	PUNCT
dti-1314	265	1	philadelphia	philadelphia	PROPN
dti-1314	265	2	:	:	PUNCT
dti-1314	266	1	lippincott	lippincott	PROPN
dti-1314	266	2	,	,	PUNCT
dti-1314	266	3	williams	williams	PROPN
dti-1314	266	4	&	&	CCONJ
dti-1314	266	5	wilkins	wilkins	PROPN
dti-1314	266	6	.	.	PUNCT
dti-1314	267	1	dillon	dillon	PROPN
dti-1314	267	2	,	,	PUNCT
dti-1314	267	3	b.j	b.j	PROPN
dti-1314	267	4	.	.	PROPN
dti-1314	267	5	,	,	PUNCT
dti-1314	267	6	prieto	prieto	PROPN
dti-1314	267	7	,	,	PUNCT
dti-1314	267	8	v.g	v.g	PROPN
dti-1314	267	9	.	.	PROPN
dti-1314	267	10	,	,	PUNCT
dti-1314	267	11	curley	curley	PROPN
dti-1314	267	12	,	,	PUNCT
dti-1314	267	13	s.a	s.a	PROPN
dti-1314	267	14	.	.	PROPN
dti-1314	267	15	et	et	PROPN
dti-1314	267	16	al	al	PROPN
dti-1314	267	17	.	.	PROPN
dti-1314	267	18	2004	2004	NUM
dti-1314	267	19	.	.	PUNCT
dti-1314	268	1	incidence	incidence	NOUN
dti-1314	268	2	and	and	CCONJ
dti-1314	268	3	distribution	distribution	NOUN
dti-1314	268	4	of	of	ADP
dti-1314	268	5	argininosuccinate	argininosuccinate	ADJ
dti-1314	268	6	synthetase	synthetase	NOUN
dti-1314	268	7	defi	defi	NOUN
dti-1314	268	8	ciency	ciency	NOUN
dti-1314	268	9	in	in	ADP
dti-1314	268	10	human	human	ADJ
dti-1314	268	11	cancers	cancer	NOUN
dti-1314	268	12	:	:	PUNCT
dti-1314	268	13	a	a	DET
dti-1314	268	14	method	method	NOUN
dti-1314	268	15	for	for	ADP
dti-1314	268	16	identifying	identify	VERB
dti-1314	268	17	cancers	cancer	NOUN
dti-1314	268	18	sensitive	sensitive	ADJ
dti-1314	268	19	to	to	ADP
dti-1314	268	20	arginine	arginine	NOUN
dti-1314	268	21	deprivation	deprivation	NOUN
dti-1314	268	22	.	.	PUNCT
dti-1314	269	1	cancer	cancer	NOUN
dti-1314	269	2	,	,	PUNCT
dti-1314	269	3	100:826–33	100:826–33	PROPN
dti-1314	269	4	ensor	ensor	PROPN
dti-1314	269	5	,	,	PUNCT
dti-1314	269	6	c.m	c.m	PROPN
dti-1314	269	7	.	.	PROPN
dti-1314	269	8	,	,	PUNCT
dti-1314	269	9	holtsberg	holtsberg	PROPN
dti-1314	269	10	,	,	PUNCT
dti-1314	269	11	f.w	f.w	PROPN
dti-1314	269	12	.	.	PROPN
dti-1314	269	13	,	,	PUNCT
dti-1314	269	14	bomalaski	bomalaski	PROPN
dti-1314	269	15	,	,	PUNCT
dti-1314	269	16	j.s	j.s	PROPN
dti-1314	269	17	.	.	PROPN
dti-1314	269	18	et	et	PROPN
dti-1314	269	19	al	al	PROPN
dti-1314	269	20	.	.	PROPN
dti-1314	269	21	2002	2002	NUM
dti-1314	269	22	.	.	PUNCT
dti-1314	270	1	pegylated	pegylate	VERB
dti-1314	270	2	arginine	arginine	NOUN
dti-1314	270	3	deiminase	deiminase	NOUN
dti-1314	270	4	(	(	PUNCT
dti-1314	270	5	adi	adi	NOUN
dti-1314	270	6	ss	ss	PROPN
dti-1314	270	7	peg20,000	peg20,000	PROPN
dti-1314	270	8	mw	mw	X
dti-1314	270	9	)	)	PUNCT
dti-1314	270	10	inhibits	inhibit	VERB
dti-1314	270	11	human	human	ADJ
dti-1314	270	12	melanomas	melanoma	NOUN
dti-1314	270	13	and	and	CCONJ
dti-1314	270	14	hepatocellular	hepatocellular	ADJ
dti-1314	270	15	carcinomas	carcinoma	NOUN
dti-1314	270	16	in	in	ADP
dti-1314	270	17	vitro	vitro	X
dti-1314	270	18	and	and	CCONJ
dti-1314	270	19	in	in	ADP
dti-1314	270	20	vivo	vivo	NOUN
dti-1314	270	21	.	.	PUNCT
dti-1314	271	1	cancer	cancer	NOUN
dti-1314	271	2	res	re	NOUN
dti-1314	271	3	.	.	PROPN
dti-1314	271	4	,	,	PUNCT
dti-1314	271	5	62:5443–50	62:5443–50	NUM
dti-1314	271	6	.	.	PUNCT
dti-1314	272	1	feun	feun	PROPN
dti-1314	272	2	,	,	PUNCT
dti-1314	272	3	l.	l.	PROPN
dti-1314	272	4	and	and	CCONJ
dti-1314	272	5	savaraj	savaraj	VERB
dti-1314	272	6	,	,	PUNCT
dti-1314	272	7	n.	n.	PROPN
dti-1314	272	8	2006	2006	NUM
dti-1314	272	9	.	.	PUNCT
dti-1314	273	1	pegylated	pegylate	VERB
dti-1314	273	2	arginine	arginine	NOUN
dti-1314	273	3	deiminase	deiminase	PROPN
dti-1314	273	4	:	:	PUNCT
dti-1314	273	5	a	a	DET
dti-1314	273	6	novel	novel	ADJ
dti-1314	273	7	anticancer	anticancer	NOUN
dti-1314	273	8	enzyme	enzyme	NOUN
dti-1314	273	9	agent	agent	NOUN
dti-1314	273	10	.	.	PUNCT
dti-1314	274	1	expert	expert	NOUN
dti-1314	274	2	.	.	PUNCT
dti-1314	275	1	opin	opin	NOUN
dti-1314	275	2	.	.	PUNCT
dti-1314	276	1	investig	investig	PROPN
dti-1314	276	2	.	.	PUNCT
dti-1314	277	1	drugs	drug	NOUN
dti-1314	277	2	,	,	PUNCT
dti-1314	277	3	15:815–22	15:815–22	PROPN
dti-1314	277	4	.	.	PUNCT
dti-1314	278	1	gong	gong	PROPN
dti-1314	278	2	,	,	PUNCT
dti-1314	278	3	h.	h.	PROPN
dti-1314	278	4	,	,	PUNCT
dti-1314	278	5	zolzer	zolzer	NOUN
dti-1314	278	6	,	,	PUNCT
dti-1314	278	7	f.	f.	PROPN
dti-1314	278	8	,	,	PUNCT
dti-1314	278	9	von	von	PROPN
dti-1314	278	10	,	,	PUNCT
dti-1314	278	11	recklinghausen	recklinghausen	PROPN
dti-1314	278	12	,	,	PUNCT
dti-1314	278	13	g.	g.	PROPN
dti-1314	278	14	et	et	PROPN
dti-1314	278	15	al	al	PROPN
dti-1314	278	16	.	.	PROPN
dti-1314	278	17	2000	2000	NUM
dti-1314	278	18	.	.	PUNCT
dti-1314	279	1	arginine	arginine	PROPN
dti-1314	279	2	deiminase	deiminase	VERB
dti-1314	279	3	inhibits	inhibit	VERB
dti-1314	279	4	proliferation	proliferation	NOUN
dti-1314	279	5	of	of	ADP
dti-1314	279	6	human	human	ADJ
dti-1314	279	7	leukemia	leukemia	NOUN
dti-1314	279	8	cells	cell	NOUN
dti-1314	279	9	more	more	ADV
dti-1314	279	10	potently	potently	ADV
dti-1314	279	11	than	than	ADP
dti-1314	279	12	asparaginase	asparaginase	ADV
dti-1314	279	13	by	by	ADP
dti-1314	279	14	inducing	induce	VERB
dti-1314	279	15	cell	cell	NOUN
dti-1314	279	16	cycle	cycle	NOUN
dti-1314	279	17	arrest	arrest	NOUN
dti-1314	279	18	and	and	CCONJ
dti-1314	279	19	apoptosis	apoptosis	NOUN
dti-1314	279	20	.	.	PUNCT
dti-1314	280	1	leukemia	leukemia	NOUN
dti-1314	280	2	,	,	PUNCT
dti-1314	280	3	14:826–9	14:826–9	NUM
dti-1314	280	4	.	.	PUNCT
dti-1314	281	1	hoefl	hoefl	PROPN
dti-1314	281	2	ich	ich	PROPN
dti-1314	281	3	,	,	PUNCT
dti-1314	281	4	k.p	k.p	PROPN
dti-1314	281	5	.	.	PROPN
dti-1314	281	6	,	,	PUNCT
dti-1314	281	7	gray	gray	PROPN
dti-1314	281	8	,	,	PUNCT
dti-1314	281	9	d.c	d.c	PROPN
dti-1314	281	10	.	.	PROPN
dti-1314	281	11	,	,	PUNCT
dti-1314	281	12	eby	eby	PROPN
dti-1314	281	13	,	,	PUNCT
dti-1314	281	14	m.t	m.t	PROPN
dti-1314	281	15	.	.	PROPN
dti-1314	281	16	et	et	PROPN
dti-1314	281	17	al	al	PROPN
dti-1314	281	18	.	.	PROPN
dti-1314	281	19	2006	2006	NUM
dti-1314	281	20	.	.	PUNCT
dti-1314	282	1	oncogenic	oncogenic	ADJ
dti-1314	282	2	braf	braf	NOUN
dti-1314	282	3	is	be	AUX
dti-1314	282	4	required	require	VERB
dti-1314	282	5	for	for	ADP
dti-1314	282	6	tumor	tumor	NOUN
dti-1314	282	7	growth	growth	NOUN
dti-1314	282	8	and	and	CCONJ
dti-1314	282	9	maintenance	maintenance	NOUN
dti-1314	282	10	in	in	ADP
dti-1314	282	11	melanoma	melanoma	NOUN
dti-1314	282	12	models	model	NOUN
dti-1314	282	13	.	.	PUNCT
dti-1314	283	1	cancer	cancer	NOUN
dti-1314	283	2	res	re	NOUN
dti-1314	283	3	.	.	PUNCT
dti-1314	283	4	,	,	PUNCT
dti-1314	283	5	66:999–1006	66:999–1006	NOUN
dti-1314	283	6	.	.	PUNCT
dti-1314	284	1	husson	husson	PROPN
dti-1314	284	2	,	,	PUNCT
dti-1314	284	3	a.	a.	NOUN
dti-1314	284	4	,	,	PUNCT
dti-1314	284	5	gautier	gautier	NOUN
dti-1314	284	6	,	,	PUNCT
dti-1314	284	7	c.	c.	PROPN
dti-1314	284	8	and	and	CCONJ
dti-1314	284	9	vaillant	vaillant	PROPN
dti-1314	284	10	r.	r.	PROPN
dti-1314	284	11	1975	1975	NUM
dti-1314	284	12	.	.	PUNCT
dti-1314	285	1	[	[	X
dti-1314	285	2	control	control	NOUN
dti-1314	285	3	activities	activity	NOUN
dti-1314	285	4	and	and	CCONJ
dti-1314	285	5	regulation	regulation	NOUN
dti-1314	285	6	by	by	ADP
dti-1314	285	7	the	the	DET
dti-1314	285	8	glucocorticoids	glucocorticoid	NOUN
dti-1314	285	9	of	of	ADP
dti-1314	285	10	three	three	NUM
dti-1314	285	11	urea	urea	ADJ
dti-1314	285	12	-	-	PUNCT
dti-1314	285	13	cycle	cycle	NOUN
dti-1314	285	14	enzymes	enzyme	NOUN
dti-1314	285	15	in	in	ADP
dti-1314	285	16	rat	rat	NOUN
dti-1314	285	17	foetal	foetal	ADJ
dti-1314	285	18	liver	liver	NOUN
dti-1314	285	19	:	:	PUNCT
dti-1314	285	20	argininosuccinate	argininosuccinate	NOUN
dti-1314	285	21	synthetase	synthetase	NOUN
dti-1314	285	22	,	,	PUNCT
dti-1314	285	23	argininosuccinase	argininosuccinase	NOUN
dti-1314	285	24	and	and	CCONJ
dti-1314	285	25	arginase	arginase	PROPN
dti-1314	285	26	(	(	PUNCT
dti-1314	285	27	author	author	PROPN
dti-1314	285	28	’s	’s	PART
dti-1314	285	29	transl	transl	PROPN
dti-1314	285	30	)	)	PUNCT
dti-1314	285	31	]	]	PUNCT
dti-1314	285	32	.	.	PUNCT
dti-1314	286	1	experientia	experientia	PROPN
dti-1314	286	2	,	,	PUNCT
dti-1314	286	3	31:1403–5	31:1403–5	NUM
dti-1314	286	4	.	.	PUNCT
dti-1314	287	1	husson	husson	PROPN
dti-1314	287	2	,	,	PUNCT
dti-1314	287	3	a.	a.	NOUN
dti-1314	287	4	and	and	CCONJ
dti-1314	287	5	vaillant	vaillant	PROPN
dti-1314	287	6	,	,	PUNCT
dti-1314	287	7	r.	r.	PROPN
dti-1314	287	8	1979	1979	NUM
dti-1314	287	9	.	.	PUNCT
dti-1314	288	1	hormonal	hormonal	ADJ
dti-1314	288	2	regulation	regulation	NOUN
dti-1314	288	3	of	of	ADP
dti-1314	288	4	three	three	NUM
dti-1314	288	5	urea	urea	NOUN
dti-1314	288	6	cycle	cycle	NOUN
dti-1314	288	7	enzymes	enzyme	NOUN
dti-1314	288	8	in	in	ADP
dti-1314	288	9	rat	rat	NOUN
dti-1314	288	10	fetal	fetal	ADJ
dti-1314	288	11	liver	liver	NOUN
dti-1314	288	12	.	.	PUNCT
dti-1314	289	1	biol	biol	PROPN
dti-1314	289	2	.	.	PUNCT
dti-1314	290	1	neonate	neonate	PROPN
dti-1314	290	2	.	.	PUNCT
dti-1314	290	3	,	,	PUNCT
dti-1314	291	1	35:74–81	35:74–81	NUM
dti-1314	291	2	.	.	PUNCT
dti-1314	292	1	husson	husson	PROPN
dti-1314	292	2	,	,	PUNCT
dti-1314	292	3	a.	a.	NOUN
dti-1314	292	4	and	and	CCONJ
dti-1314	292	5	vaillant	vaillant	PROPN
dti-1314	292	6	,	,	PUNCT
dti-1314	292	7	r.	r.	PROPN
dti-1314	292	8	1982	1982	NUM
dti-1314	292	9	.	.	PUNCT
dti-1314	293	1	effects	effect	NOUN
dti-1314	293	2	of	of	ADP
dti-1314	293	3	glucocorticosteroids	glucocorticosteroid	NOUN
dti-1314	293	4	and	and	CCONJ
dti-1314	293	5	glucagon	glucagon	NOUN
dti-1314	293	6	on	on	ADP
dti-1314	293	7	argininosuccinate	argininosuccinate	NOUN
dti-1314	293	8	synthetase	synthetase	NOUN
dti-1314	293	9	,	,	PUNCT
dti-1314	293	10	argninosuccinase	argninosuccinase	ADJ
dti-1314	293	11	,	,	PUNCT
dti-1314	293	12	and	and	CCONJ
dti-1314	293	13	arginase	arginase	NOUN
dti-1314	293	14	in	in	ADP
dti-1314	293	15	fetal	fetal	ADJ
dti-1314	293	16	rat	rat	NOUN
dti-1314	293	17	liver	liver	NOUN
dti-1314	293	18	.	.	PUNCT
dti-1314	294	1	endocrinology	endocrinology	NOUN
dti-1314	294	2	,	,	PUNCT
dti-1314	294	3	110:227–32	110:227–32	NUM
dti-1314	294	4	.	.	PUNCT
dti-1314	295	1	husson	husson	PROPN
dti-1314	295	2	,	,	PUNCT
dti-1314	295	3	a.	a.	NOUN
dti-1314	295	4	,	,	PUNCT
dti-1314	295	5	guechairi	guechairi	PROPN
dti-1314	295	6	,	,	PUNCT
dti-1314	295	7	m.	m.	NOUN
dti-1314	295	8	,	,	PUNCT
dti-1314	295	9	fairand	fairand	ADV
dti-1314	295	10	,	,	PUNCT
dti-1314	295	11	a.	a.	NOUN
dti-1314	295	12	et	et	PROPN
dti-1314	295	13	al	al	PROPN
dti-1314	295	14	.	.	PROPN
dti-1314	295	15	1986	1986	NUM
dti-1314	295	16	.	.	PUNCT
dti-1314	296	1	effects	effect	NOUN
dti-1314	296	2	of	of	ADP
dti-1314	296	3	pancreatic	pancreatic	ADJ
dti-1314	296	4	hormones	hormone	NOUN
dti-1314	296	5	and	and	CCONJ
dti-1314	296	6	glucocorticosteroids	glucocorticosteroid	NOUN
dti-1314	296	7	on	on	ADP
dti-1314	296	8	argininosuccinate	argininosuccinate	NOUN
dti-1314	296	9	synthetase	synthetase	NOUN
dti-1314	296	10	and	and	CCONJ
dti-1314	296	11	argininosuccinase	argininosuccinase	NOUN
dti-1314	296	12	activities	activity	NOUN
dti-1314	296	13	of	of	ADP
dti-1314	296	14	rat	rat	NOUN
dti-1314	296	15	liver	liver	NOUN
dti-1314	296	16	during	during	ADP
dti-1314	296	17	the	the	DET
dti-1314	296	18	perinatal	perinatal	ADJ
dti-1314	296	19	period	period	NOUN
dti-1314	296	20	:	:	PUNCT
dti-1314	296	21	in	in	ADP
dti-1314	296	22	vivo	vivo	NOUN
dti-1314	296	23	and	and	CCONJ
dti-1314	296	24	in	in	ADP
dti-1314	296	25	vitro	vitro	X
dti-1314	296	26	studies	study	NOUN
dti-1314	296	27	.	.	PUNCT
dti-1314	297	1	endocrinology	endocrinology	NOUN
dti-1314	297	2	,	,	PUNCT
dti-1314	297	3	119:1171–7	119:1171–7	NUM
dti-1314	297	4	.	.	PUNCT
dti-1314	298	1	husson	husson	PROPN
dti-1314	298	2	,	,	PUNCT
dti-1314	298	3	a.	a.	NOUN
dti-1314	298	4	,	,	PUNCT
dti-1314	298	5	brasse	brasse	NOUN
dti-1314	298	6	-	-	PUNCT
dti-1314	298	7	lagnel	lagnel	PROPN
dti-1314	298	8	,	,	PUNCT
dti-1314	298	9	c.	c.	NOUN
dti-1314	298	10	,	,	PUNCT
dti-1314	298	11	fairand	fairand	ADV
dti-1314	298	12	,	,	PUNCT
dti-1314	298	13	a.	a.	PROPN
dti-1314	298	14	et	et	PROPN
dti-1314	298	15	al	al	PROPN
dti-1314	298	16	.	.	PROPN
dti-1314	298	17	2003	2003	NUM
dti-1314	298	18	.	.	PUNCT
dti-1314	299	1	argininosuccinate	argininosuccinate	NOUN
dti-1314	299	2	synthetase	synthetase	NOUN
dti-1314	299	3	from	from	ADP
dti-1314	299	4	the	the	DET
dti-1314	299	5	urea	urea	NOUN
dti-1314	299	6	cycle	cycle	NOUN
dti-1314	299	7	to	to	ADP
dti-1314	299	8	the	the	DET
dti-1314	299	9	citrulline	citrulline	NOUN
dti-1314	299	10	-	-	PUNCT
dti-1314	299	11	no	no	NOUN
dti-1314	299	12	cycle	cycle	NOUN
dti-1314	299	13	.	.	PUNCT
dti-1314	300	1	eur	eur	PROPN
dti-1314	300	2	.	.	PUNCT
dti-1314	301	1	j.	j.	PROPN
dti-1314	301	2	biochem	biochem	PROPN
dti-1314	301	3	.	.	PUNCT
dti-1314	301	4	,	,	PUNCT
dti-1314	302	1	270:1887–99	270:1887–99	NUM
dti-1314	302	2	.	.	PUNCT
dti-1314	303	1	izzo	izzo	PROPN
dti-1314	303	2	,	,	PUNCT
dti-1314	303	3	f.	f.	PROPN
dti-1314	303	4	,	,	PUNCT
dti-1314	303	5	marra	marra	PROPN
dti-1314	303	6	,	,	PUNCT
dti-1314	303	7	p.	p.	PROPN
dti-1314	303	8	,	,	PUNCT
dti-1314	303	9	beneduce	beneduce	NOUN
dti-1314	303	10	,	,	PUNCT
dti-1314	303	11	g.	g.	PROPN
dti-1314	303	12	et	et	PROPN
dti-1314	303	13	al	al	PROPN
dti-1314	303	14	.	.	PROPN
dti-1314	303	15	2004	2004	NUM
dti-1314	303	16	.	.	PUNCT
dti-1314	304	1	pegylated	pegylate	VERB
dti-1314	304	2	arginine	arginine	NOUN
dti-1314	304	3	deiminase	deiminase	VERB
dti-1314	304	4	treatment	treatment	NOUN
dti-1314	304	5	of	of	ADP
dti-1314	304	6	patients	patient	NOUN
dti-1314	304	7	with	with	ADP
dti-1314	304	8	unresectable	unresectable	ADJ
dti-1314	304	9	hepatocellular	hepatocellular	ADJ
dti-1314	304	10	carcinoma	carcinoma	NOUN
dti-1314	304	11	:	:	PUNCT
dti-1314	304	12	results	result	NOUN
dti-1314	304	13	from	from	ADP
dti-1314	304	14	phase	phase	NOUN
dti-1314	304	15	i	i	PROPN
dti-1314	304	16	/	/	SYM
dti-1314	304	17	ii	ii	PROPN
dti-1314	304	18	studies	study	NOUN
dti-1314	304	19	.	.	PUNCT
dti-1314	305	1	j.	j.	PROPN
dti-1314	305	2	clin	clin	PROPN
dti-1314	305	3	.	.	PUNCT
dti-1314	306	1	oncol	oncol	PROPN
dti-1314	306	2	.	.	PUNCT
dti-1314	306	3	,	,	PUNCT
dti-1314	306	4	22:1815–22	22:1815–22	NUM
dti-1314	306	5	.	.	PUNCT
dti-1314	307	1	jackson	jackson	PROPN
dti-1314	307	2	,	,	PUNCT
dti-1314	307	3	m.j	m.j	PROPN
dti-1314	307	4	.	.	PROPN
dti-1314	307	5	,	,	PUNCT
dti-1314	307	6	zielke	zielke	PROPN
dti-1314	307	7	,	,	PUNCT
dti-1314	307	8	h.r	h.r	PROPN
dti-1314	307	9	.	.	PROPN
dti-1314	307	10	and	and	CCONJ
dti-1314	307	11	zielke	zielke	ADV
dti-1314	307	12	,	,	PUNCT
dti-1314	307	13	c.l	c.l	PROPN
dti-1314	307	14	.	.	PROPN
dti-1314	307	15	1996	1996	NUM
dti-1314	307	16	.	.	PUNCT
dti-1314	308	1	induction	induction	NOUN
dti-1314	308	2	of	of	ADP
dti-1314	308	3	astrocyte	astrocyte	NOUN
dti-1314	308	4	argininosuccinate	argininosuccinate	NOUN
dti-1314	308	5	synthetase	synthetase	NOUN
dti-1314	308	6	and	and	CCONJ
dti-1314	308	7	argininosuccinate	argininosuccinate	NOUN
dti-1314	308	8	lyase	lyase	NOUN
dti-1314	308	9	by	by	ADP
dti-1314	308	10	dibutyryl	dibutyryl	NOUN
dti-1314	308	11	cyclic	cyclic	PROPN
dti-1314	308	12	amp	amp	NOUN
dti-1314	308	13	and	and	CCONJ
dti-1314	308	14	dexamethasone	dexamethasone	NOUN
dti-1314	308	15	.	.	PUNCT
dti-1314	309	1	neurochem	neurochem	PROPN
dti-1314	309	2	.	.	PUNCT
dti-1314	310	1	res	re	NOUN
dti-1314	310	2	.	.	PROPN
dti-1314	310	3	,	,	PUNCT
dti-1314	310	4	21:1161–5	21:1161–5	NUM
dti-1314	310	5	.	.	PUNCT
dti-1314	311	1	keilholz	keilholz	PROPN
dti-1314	311	2	,	,	PUNCT
dti-1314	311	3	u.	u.	PROPN
dti-1314	311	4	and	and	CCONJ
dti-1314	311	5	gore	gore	PROPN
dti-1314	311	6	,	,	PUNCT
dti-1314	311	7	m.e	m.e	PROPN
dti-1314	311	8	.	.	PROPN
dti-1314	311	9	2002	2002	NUM
dti-1314	311	10	.	.	PUNCT
dti-1314	312	1	biochemotherapy	biochemotherapy	PROPN
dti-1314	312	2	for	for	ADP
dti-1314	312	3	advanced	advanced	ADJ
dti-1314	312	4	melanoma	melanoma	NOUN
dti-1314	312	5	.	.	PUNCT
dti-1314	313	1	semin	semin	PROPN
dti-1314	313	2	.	.	PUNCT
dti-1314	314	1	oncol	oncol	PROPN
dti-1314	314	2	.	.	PUNCT
dti-1314	314	3	,	,	PUNCT
dti-1314	314	4	29:456–61	29:456–61	NUM
dti-1314	314	5	.	.	PUNCT
dti-1314	315	1	lin	lin	PROPN
dti-1314	315	2	,	,	PUNCT
dti-1314	315	3	r.c	r.c	PROPN
dti-1314	315	4	.	.	PROPN
dti-1314	315	5	,	,	PUNCT
dti-1314	315	6	snodgrass	snodgrass	PROPN
dti-1314	315	7	,	,	PUNCT
dti-1314	315	8	p.j	p.j	PROPN
dti-1314	315	9	.	.	PROPN
dti-1314	315	10	and	and	CCONJ
dti-1314	315	11	rabier	rabier	NOUN
dti-1314	315	12	,	,	PUNCT
dti-1314	315	13	d.	d.	PROPN
dti-1314	315	14	1982	1982	NUM
dti-1314	315	15	.	.	PUNCT
dti-1314	316	1	induction	induction	NOUN
dti-1314	316	2	of	of	ADP
dti-1314	316	3	urea	urea	NOUN
dti-1314	316	4	cycle	cycle	NOUN
dti-1314	316	5	enzymes	enzyme	NOUN
dti-1314	316	6	by	by	ADP
dti-1314	316	7	glucagon	glucagon	NOUN
dti-1314	316	8	and	and	CCONJ
dti-1314	316	9	dexamethasone	dexamethasone	NOUN
dti-1314	316	10	in	in	ADP
dti-1314	316	11	monolayer	monolayer	NOUN
dti-1314	316	12	cultures	culture	NOUN
dti-1314	316	13	of	of	ADP
dti-1314	316	14	adult	adult	NOUN
dti-1314	316	15	rat	rat	NOUN
dti-1314	316	16	hepatocytes	hepatocyte	NOUN
dti-1314	316	17	.	.	PUNCT
dti-1314	317	1	j.	j.	PROPN
dti-1314	317	2	biol	biol	PROPN
dti-1314	317	3	.	.	PUNCT
dti-1314	318	1	chem	chem	PROPN
dti-1314	318	2	.	.	PUNCT
dti-1314	318	3	,	,	PUNCT
dti-1314	318	4	257:5061–7	257:5061–7	PROPN
dti-1314	318	5	.	.	PUNCT
dti-1314	319	1	miyazaki	miyazaki	PROPN
dti-1314	319	2	,	,	PUNCT
dti-1314	319	3	k.	k.	PROPN
dti-1314	319	4	,	,	PUNCT
dti-1314	319	5	takaku	takaku	PROPN
dti-1314	319	6	,	,	PUNCT
dti-1314	319	7	h.	h.	PROPN
dti-1314	319	8	,	,	PUNCT
dti-1314	319	9	umeda	umeda	PROPN
dti-1314	319	10	,	,	PUNCT
dti-1314	319	11	m.	m.	NOUN
dti-1314	319	12	et	et	PROPN
dti-1314	319	13	al	al	PROPN
dti-1314	319	14	.	.	PROPN
dti-1314	319	15	1990	1990	NUM
dti-1314	319	16	.	.	PUNCT
dti-1314	320	1	potent	potent	ADJ
dti-1314	320	2	growth	growth	NOUN
dti-1314	320	3	inhibition	inhibition	NOUN
dti-1314	320	4	of	of	ADP
dti-1314	320	5	human	human	ADJ
dti-1314	320	6	tumor	tumor	NOUN
dti-1314	320	7	cells	cell	NOUN
dti-1314	320	8	in	in	ADP
dti-1314	320	9	culture	culture	NOUN
dti-1314	320	10	by	by	ADP
dti-1314	320	11	arginine	arginine	NOUN
dti-1314	320	12	deiminase	deiminase	VERB
dti-1314	320	13	purifi	purifi	PROPN
dti-1314	320	14	ed	ed	NOUN
dti-1314	320	15	from	from	ADP
dti-1314	320	16	a	a	DET
dti-1314	320	17	culture	culture	NOUN
dti-1314	320	18	medium	medium	NOUN
dti-1314	320	19	of	of	ADP
dti-1314	320	20	a	a	DET
dti-1314	320	21	mycoplasma	mycoplasma	NOUN
dti-1314	320	22	-	-	PUNCT
dti-1314	320	23	infected	infect	VERB
dti-1314	320	24	cell	cell	NOUN
dti-1314	320	25	line	line	NOUN
dti-1314	320	26	.	.	PUNCT
dti-1314	321	1	cancer	cancer	NOUN
dti-1314	321	2	res	re	NOUN
dti-1314	321	3	.	.	PUNCT
dti-1314	321	4	,	,	PUNCT
dti-1314	321	5	50:4522–7	50:4522–7	X
dti-1314	321	6	.	.	PUNCT
dti-1314	322	1	noh	noh	PROPN
dti-1314	322	2	,	,	PUNCT
dti-1314	322	3	e.j	e.j	PROPN
dti-1314	322	4	.	.	PROPN
dti-1314	322	5	,	,	PUNCT
dti-1314	322	6	kang	kang	PROPN
dti-1314	322	7	,	,	PUNCT
dti-1314	322	8	s.w	s.w	PROPN
dti-1314	322	9	.	.	PROPN
dti-1314	322	10	,	,	PUNCT
dti-1314	322	11	shin	shin	PROPN
dti-1314	322	12	,	,	PUNCT
dti-1314	322	13	y.j	y.j	PROPN
dti-1314	322	14	.	.	PROPN
dti-1314	322	15	et	et	PROPN
dti-1314	323	1	al	al	PROPN
dti-1314	323	2	.	.	PROPN
dti-1314	323	3	2004	2004	NUM
dti-1314	323	4	.	.	PUNCT
dti-1314	324	1	arginine	arginine	NOUN
dti-1314	324	2	deiminase	deiminase	NOUN
dti-1314	324	3	enhances	enhance	VERB
dti-1314	324	4	dexamethasone	dexamethasone	NOUN
dti-1314	324	5	-	-	PUNCT
dti-1314	324	6	induced	induce	VERB
dti-1314	324	7	cytotoxicity	cytotoxicity	NOUN
dti-1314	324	8	in	in	ADP
dti-1314	324	9	human	human	PROPN
dti-1314	324	10	t	t	PROPN
dti-1314	324	11	-	-	PUNCT
dti-1314	324	12	lymphoblastic	lymphoblastic	ADJ
dti-1314	324	13	leukemia	leukemia	NOUN
dti-1314	324	14	ccrf	ccrf	NOUN
dti-1314	324	15	-	-	PUNCT
dti-1314	324	16	cem	cem	NOUN
dti-1314	324	17	cells	cell	NOUN
dti-1314	324	18	.	.	PUNCT
dti-1314	325	1	int	int	NOUN
dti-1314	325	2	.	.	PUNCT
dti-1314	326	1	j.	j.	PROPN
dti-1314	326	2	cancer	cancer	PROPN
dti-1314	326	3	,	,	PUNCT
dti-1314	326	4	112:502–8	112:502–8	NUM
dti-1314	326	5	.	.	PUNCT
dti-1314	327	1	philip	philip	PROPN
dti-1314	327	2	,	,	PUNCT
dti-1314	327	3	r.	r.	PROPN
dti-1314	327	4	,	,	PUNCT
dti-1314	327	5	campbell	campbell	PROPN
dti-1314	327	6	,	,	PUNCT
dti-1314	327	7	e.	e.	PROPN
dti-1314	327	8	and	and	CCONJ
dti-1314	327	9	wheatley	wheatley	PROPN
dti-1314	327	10	,	,	PUNCT
dti-1314	327	11	d.n	d.n	PROPN
dti-1314	327	12	.	.	PROPN
dti-1314	327	13	2003	2003	NUM
dti-1314	327	14	.	.	PUNCT
dti-1314	327	15	arginine	arginine	NOUN
dti-1314	327	16	deprivation	deprivation	NOUN
dti-1314	327	17	,	,	PUNCT
dti-1314	327	18	growth	growth	NOUN
dti-1314	327	19	inhibition	inhibition	NOUN
dti-1314	327	20	and	and	CCONJ
dti-1314	327	21	tumour	tumour	NOUN
dti-1314	327	22	cell	cell	NOUN
dti-1314	327	23	death	death	NOUN
dti-1314	327	24	:	:	PUNCT
dti-1314	327	25	2	2	X
dti-1314	327	26	.	.	X
dti-1314	327	27	enzymatic	enzymatic	ADJ
dti-1314	327	28	degradation	degradation	NOUN
dti-1314	327	29	of	of	ADP
dti-1314	327	30	arginine	arginine	NOUN
dti-1314	327	31	in	in	ADP
dti-1314	327	32	normal	normal	ADJ
dti-1314	327	33	and	and	CCONJ
dti-1314	327	34	malignant	malignant	ADJ
dti-1314	327	35	cell	cell	NOUN
dti-1314	327	36	cultures	culture	NOUN
dti-1314	327	37	.	.	PUNCT
dti-1314	328	1	br	br	X
dti-1314	328	2	.	.	PUNCT
dti-1314	329	1	j.	j.	PROPN
dti-1314	329	2	cancer	cancer	PROPN
dti-1314	329	3	,	,	PUNCT
dti-1314	329	4	88:613–23	88:613–23	ADV
dti-1314	329	5	.	.	PUNCT
dti-1314	330	1	punt	punt	NOUN
dti-1314	330	2	,	,	PUNCT
dti-1314	330	3	c.j	c.j	PROPN
dti-1314	330	4	.	.	PROPN
dti-1314	330	5	,	,	PUNCT
dti-1314	330	6	suciu	suciu	PROPN
dti-1314	330	7	,	,	PUNCT
dti-1314	330	8	s.	s.	PROPN
dti-1314	330	9	,	,	PUNCT
dti-1314	330	10	gore	gore	PROPN
dti-1314	330	11	,	,	PUNCT
dti-1314	330	12	m.a	m.a	PROPN
dti-1314	330	13	.	.	PROPN
dti-1314	330	14	et	et	PROPN
dti-1314	330	15	al	al	PROPN
dti-1314	330	16	.	.	PROPN
dti-1314	330	17	2006	2006	NUM
dti-1314	330	18	.	.	PUNCT
dti-1314	331	1	chemoimmunotherapy	chemoimmunotherapy	NOUN
dti-1314	331	2	with	with	ADP
dti-1314	331	3	dacarbazine	dacarbazine	NOUN
dti-1314	331	4	,	,	PUNCT
dti-1314	331	5	cisplatin	cisplatin	NOUN
dti-1314	331	6	,	,	PUNCT
dti-1314	331	7	interferon	interferon	ADJ
dti-1314	331	8	-	-	PUNCT
dti-1314	331	9	alpha2b	alpha2b	NOUN
dti-1314	331	10	and	and	CCONJ
dti-1314	331	11	interleukin-2	interleukin-2	NOUN
dti-1314	331	12	versus	versus	ADP
dti-1314	331	13	two	two	NUM
dti-1314	331	14	cycles	cycle	NOUN
dti-1314	331	15	of	of	ADP
dti-1314	331	16	dacarbazine	dacarbazine	NOUN
dti-1314	331	17	followed	follow	VERB
dti-1314	331	18	by	by	ADP
dti-1314	331	19	chemoimmunotherapy	chemoimmunotherapy	NOUN
dti-1314	331	20	in	in	ADP
dti-1314	331	21	patients	patient	NOUN
dti-1314	331	22	with	with	ADP
dti-1314	331	23	metastatic	metastatic	ADJ
dti-1314	331	24	melanoma	melanoma	NOUN
dti-1314	331	25	:	:	PUNCT
dti-1314	331	26	a	a	DET
dti-1314	331	27	randomised	randomised	ADJ
dti-1314	331	28	phase	phase	NOUN
dti-1314	331	29	ii	ii	NOUN
dti-1314	331	30	study	study	NOUN
dti-1314	331	31	of	of	ADP
dti-1314	331	32	the	the	DET
dti-1314	331	33	european	european	PROPN
dti-1314	331	34	organization	organization	PROPN
dti-1314	331	35	for	for	ADP
dti-1314	331	36	research	research	NOUN
dti-1314	331	37	and	and	CCONJ
dti-1314	331	38	treatment	treatment	NOUN
dti-1314	331	39	of	of	ADP
dti-1314	331	40	cancer	cancer	NOUN
dti-1314	331	41	melanoma	melanoma	PROPN
dti-1314	331	42	group	group	NOUN
dti-1314	331	43	.	.	PUNCT
dti-1314	332	1	eur	eur	PROPN
dti-1314	332	2	.	.	PUNCT
dti-1314	333	1	j.	j.	PROPN
dti-1314	333	2	cancer	cancer	PROPN
dti-1314	333	3	,	,	PUNCT
dti-1314	333	4	42:2991–5	42:2991–5	NUM
dti-1314	333	5	.	.	PUNCT
dti-1314	334	1	ratner	ratner	PROPN
dti-1314	334	2	,	,	PUNCT
dti-1314	334	3	s.	s.	PROPN
dti-1314	334	4	1973	1973	NUM
dti-1314	334	5	.	.	PUNCT
dti-1314	335	1	enzymes	enzyme	NOUN
dti-1314	335	2	of	of	ADP
dti-1314	335	3	arginine	arginine	NOUN
dti-1314	335	4	and	and	CCONJ
dti-1314	335	5	urea	urea	NOUN
dti-1314	335	6	synthesis	synthesis	NOUN
dti-1314	335	7	.	.	PUNCT
dti-1314	336	1	adv	adv	PROPN
dti-1314	336	2	enzymol	enzymol	PROPN
dti-1314	336	3	relat	relat	PROPN
dti-1314	336	4	areas	areas	PROPN
dti-1314	336	5	mol	mol	PROPN
dti-1314	336	6	.	.	PUNCT
dti-1314	336	7	biol	biol	PROPN
dti-1314	336	8	.	.	PUNCT
dti-1314	336	9	,	,	PUNCT
dti-1314	336	10	39:1–90	39:1–90	X
dti-1314	336	11	.	.	PUNCT
dti-1314	337	1	riker	riker	PROPN
dti-1314	337	2	,	,	PUNCT
dti-1314	337	3	a.i	a.i	PROPN
dti-1314	337	4	.	.	PROPN
dti-1314	337	5	,	,	PUNCT
dti-1314	337	6	radfar	radfar	ADV
dti-1314	337	7	,	,	PUNCT
dti-1314	337	8	s.	s.	PROPN
dti-1314	337	9	,	,	PUNCT
dti-1314	337	10	liu	liu	PROPN
dti-1314	337	11	,	,	PUNCT
dti-1314	337	12	s.	s.	PROPN
dti-1314	337	13	et	et	PROPN
dti-1314	337	14	al	al	PROPN
dti-1314	337	15	.	.	PROPN
dti-1314	337	16	2007	2007	NUM
dti-1314	337	17	.	.	PUNCT
dti-1314	338	1	immunotherapy	immunotherapy	NOUN
dti-1314	338	2	of	of	ADP
dti-1314	338	3	melanoma	melanoma	NOUN
dti-1314	338	4	:	:	PUNCT
dti-1314	338	5	a	a	DET
dti-1314	338	6	critical	critical	ADJ
dti-1314	338	7	review	review	NOUN
dti-1314	338	8	of	of	ADP
dti-1314	338	9	current	current	ADJ
dti-1314	338	10	concepts	concept	NOUN
dti-1314	338	11	and	and	CCONJ
dti-1314	338	12	future	future	ADJ
dti-1314	338	13	strategies	strategy	NOUN
dti-1314	338	14	.	.	PUNCT
dti-1314	339	1	expert	expert	NOUN
dti-1314	339	2	.	.	PUNCT
dti-1314	340	1	opin	opin	NOUN
dti-1314	340	2	.	.	PUNCT
dti-1314	341	1	biol	biol	PROPN
dti-1314	341	2	.	.	PUNCT
dti-1314	342	1	ther	ther	PROPN
dti-1314	342	2	.	.	PUNCT
dti-1314	343	1	,	,	PUNCT
dti-1314	343	2	7:345–58	7:345–58	X
dti-1314	343	3	.	.	PUNCT
dti-1314	344	1	sasse	sasse	PROPN
dti-1314	344	2	,	,	PUNCT
dti-1314	344	3	a.	a.	NOUN
dti-1314	344	4	,	,	PUNCT
dti-1314	344	5	sasse	sasse	PROPN
dti-1314	344	6	,	,	PUNCT
dti-1314	344	7	e.	e.	PROPN
dti-1314	344	8	,	,	PUNCT
dti-1314	344	9	clark	clark	PROPN
dti-1314	344	10	,	,	PUNCT
dti-1314	344	11	l.	l.	PROPN
dti-1314	344	12	et	et	PROPN
dti-1314	344	13	al	al	PROPN
dti-1314	344	14	.	.	PROPN
dti-1314	344	15	2007	2007	NUM
dti-1314	344	16	.	.	PUNCT
dti-1314	345	1	chemoimmunotherapy	chemoimmunotherapy	NOUN
dti-1314	345	2	versus	versus	ADP
dti-1314	345	3	chemotherapy	chemotherapy	NOUN
dti-1314	345	4	for	for	ADP
dti-1314	345	5	metastatic	metastatic	ADJ
dti-1314	345	6	malignant	malignant	ADJ
dti-1314	345	7	melanoma	melanoma	NOUN
dti-1314	345	8	.	.	PUNCT
dti-1314	346	1	cochrane	cochrane	NOUN
dti-1314	346	2	database	database	PROPN
dti-1314	346	3	syst	syst	PROPN
dti-1314	346	4	.	.	PUNCT
dti-1314	347	1	rev	rev	PROPN
dti-1314	347	2	.	.	PROPN
dti-1314	347	3	,	,	PUNCT
dti-1314	347	4	cd005413	cd005413	PROPN
dti-1314	347	5	.	.	PUNCT
dti-1314	348	1	scott	scott	PROPN
dti-1314	348	2	,	,	PUNCT
dti-1314	348	3	l.	l.	PROPN
dti-1314	348	4	,	,	PUNCT
dti-1314	348	5	lamb	lamb	PROPN
dti-1314	348	6	,	,	PUNCT
dti-1314	348	7	j.	j.	PROPN
dti-1314	348	8	,	,	PUNCT
dti-1314	348	9	smith	smith	PROPN
dti-1314	348	10	,	,	PUNCT
dti-1314	348	11	s.	s.	PROPN
dti-1314	348	12	et	et	PROPN
dti-1314	348	13	al	al	PROPN
dti-1314	348	14	.	.	PROPN
dti-1314	348	15	2000	2000	NUM
dti-1314	348	16	.	.	PUNCT
dti-1314	349	1	single	single	ADJ
dti-1314	349	2	amino	amino	NOUN
dti-1314	349	3	acid	acid	NOUN
dti-1314	349	4	(	(	PUNCT
dti-1314	349	5	arginine	arginine	NOUN
dti-1314	349	6	)	)	PUNCT
dti-1314	349	7	deprivation	deprivation	NOUN
dti-1314	349	8	:	:	PUNCT
dti-1314	349	9	rapid	rapid	ADJ
dti-1314	349	10	and	and	CCONJ
dti-1314	349	11	selective	selective	ADJ
dti-1314	349	12	death	death	NOUN
dti-1314	349	13	of	of	ADP
dti-1314	349	14	cultured	cultured	ADJ
dti-1314	349	15	transformed	transform	VERB
dti-1314	349	16	and	and	CCONJ
dti-1314	349	17	malignant	malignant	ADJ
dti-1314	349	18	cells	cell	NOUN
dti-1314	349	19	.	.	PUNCT
dti-1314	350	1	br	br	PROPN
dti-1314	350	2	.	.	PUNCT
dti-1314	351	1	j.	j.	PROPN
dti-1314	351	2	cancer	cancer	PROPN
dti-1314	351	3	,	,	PUNCT
dti-1314	351	4	83:800–10	83:800–10	NOUN
dti-1314	351	5	.	.	PUNCT
dti-1314	352	1	shen	shen	PROPN
dti-1314	352	2	,	,	PUNCT
dti-1314	352	3	l.j	l.j	PROPN
dti-1314	352	4	.	.	PROPN
dti-1314	352	5	,	,	PUNCT
dti-1314	352	6	lin	lin	PROPN
dti-1314	352	7	,	,	PUNCT
dti-1314	352	8	w.c	w.c	PROPN
dti-1314	352	9	.	.	PROPN
dti-1314	352	10	,	,	PUNCT
dti-1314	352	11	beloussow	beloussow	NOUN
dti-1314	352	12	,	,	PUNCT
dti-1314	352	13	k.	k.	PROPN
dti-1314	352	14	et	et	PROPN
dti-1314	352	15	al	al	PROPN
dti-1314	352	16	.	.	PROPN
dti-1314	352	17	2003	2003	NUM
dti-1314	352	18	.	.	PUNCT
dti-1314	353	1	resistance	resistance	NOUN
dti-1314	353	2	to	to	ADP
dti-1314	353	3	the	the	DET
dti-1314	353	4	antiproliferative	antiproliferative	ADJ
dti-1314	353	5	activity	activity	NOUN
dti-1314	353	6	of	of	ADP
dti-1314	353	7	recombinant	recombinant	ADJ
dti-1314	353	8	arginine	arginine	NOUN
dti-1314	353	9	deiminase	deiminase	NOUN
dti-1314	353	10	in	in	ADP
dti-1314	353	11	cell	cell	NOUN
dti-1314	353	12	culture	culture	NOUN
dti-1314	353	13	correlates	correlate	VERB
dti-1314	353	14	with	with	ADP
dti-1314	353	15	the	the	DET
dti-1314	353	16	endogenous	endogenous	ADJ
dti-1314	353	17	enzyme	enzyme	NOUN
dti-1314	353	18	,	,	PUNCT
dti-1314	353	19	argininosuccinate	argininosuccinate	ADJ
dti-1314	353	20	synthetase	synthetase	NOUN
dti-1314	353	21	.	.	PUNCT
dti-1314	354	1	cancer	cancer	PROPN
dti-1314	354	2	lett	lett	PROPN
dti-1314	354	3	.	.	PROPN
dti-1314	354	4	,	,	PUNCT
dti-1314	354	5	191:165–70	191:165–70	PROPN
dti-1314	354	6	.	.	PUNCT
dti-1314	355	1	shen	shen	PROPN
dti-1314	355	2	,	,	PUNCT
dti-1314	355	3	l.j	l.j	PROPN
dti-1314	355	4	.	.	PROPN
dti-1314	355	5	,	,	PUNCT
dti-1314	355	6	beloussow	beloussow	PROPN
dti-1314	355	7	,	,	PUNCT
dti-1314	355	8	k.	k.	PROPN
dti-1314	355	9	and	and	CCONJ
dti-1314	355	10	shen	shen	PROPN
dti-1314	355	11	,	,	PUNCT
dti-1314	355	12	w.c	w.c	PROPN
dti-1314	355	13	.	.	PROPN
dti-1314	355	14	2006	2006	NUM
dti-1314	355	15	.	.	PUNCT
dti-1314	356	1	modulation	modulation	NOUN
dti-1314	356	2	of	of	ADP
dti-1314	356	3	arginine	arginine	NOUN
dti-1314	356	4	metabolic	metabolic	NOUN
dti-1314	356	5	pathways	pathway	NOUN
dti-1314	356	6	as	as	ADP
dti-1314	356	7	the	the	DET
dti-1314	356	8	potential	potential	ADJ
dti-1314	356	9	anti	anti	ADJ
dti-1314	356	10	-	-	ADJ
dti-1314	356	11	tumor	tumor	ADJ
dti-1314	356	12	mechanism	mechanism	NOUN
dti-1314	356	13	of	of	ADP
dti-1314	356	14	recombinant	recombinant	ADJ
dti-1314	356	15	arginine	arginine	NOUN
dti-1314	356	16	deiminase	deiminase	NOUN
dti-1314	356	17	.	.	PUNCT
dti-1314	357	1	cancer	cancer	PROPN
dti-1314	357	2	lett	lett	PROPN
dti-1314	357	3	.	.	PROPN
dti-1314	357	4	,	,	PUNCT
dti-1314	357	5	231:30–5	231:30–5	X
dti-1314	357	6	.	.	PUNCT
dti-1314	357	7	shen	shen	PROPN
dti-1314	357	8	,	,	PUNCT
dti-1314	357	9	l.j	l.j	PROPN
dti-1314	357	10	.	.	PROPN
dti-1314	357	11	and	and	CCONJ
dti-1314	357	12	shen	shen	PROPN
dti-1314	357	13	,	,	PUNCT
dti-1314	357	14	w.c	w.c	PROPN
dti-1314	357	15	.	.	PROPN
dti-1314	357	16	2006	2006	NUM
dti-1314	357	17	.	.	PUNCT
dti-1314	358	1	drug	drug	NOUN
dti-1314	358	2	evaluation	evaluation	NOUN
dti-1314	358	3	:	:	PUNCT
dti-1314	358	4	adi	adi	PROPN
dti-1314	358	5	-	-	PUNCT
dti-1314	358	6	peg-20	peg-20	PROPN
dti-1314	358	7	—	—	PUNCT
dti-1314	358	8	a	a	DET
dti-1314	358	9	pegylated	pegylate	VERB
dti-1314	358	10	arginine	arginine	NOUN
dti-1314	358	11	deiminase	deiminase	NOUN
dti-1314	358	12	for	for	ADP
dti-1314	358	13	arginine	arginine	NOUN
dti-1314	358	14	-	-	PUNCT
dti-1314	358	15	auxotrophic	auxotrophic	ADJ
dti-1314	358	16	cancers	cancer	NOUN
dti-1314	358	17	.	.	PUNCT
dti-1314	359	1	curr	curr	PROPN
dti-1314	359	2	opin	opin	PROPN
dti-1314	359	3	mol	mol	ADP
dti-1314	359	4	ther	ther	ADV
dti-1314	359	5	,	,	PUNCT
dti-1314	359	6	8:240–8	8:240–8	NUM
dti-1314	359	7	sridhar	sridhar	NOUN
dti-1314	359	8	ss	ss	PROPN
dti-1314	359	9	,	,	PUNCT
dti-1314	359	10	hedley	hedley	PROPN
dti-1314	359	11	d	d	PROPN
dti-1314	359	12	and	and	CCONJ
dti-1314	359	13	siu	siu	NOUN
dti-1314	359	14	ll	ll	NOUN
dti-1314	359	15	.	.	PUNCT
dti-1314	360	1	2005	2005	NUM
dti-1314	360	2	.	.	PUNCT
dti-1314	361	1	raf	raf	PROPN
dti-1314	361	2	kinase	kinase	PROPN
dti-1314	361	3	as	as	ADP
dti-1314	361	4	a	a	DET
dti-1314	361	5	target	target	NOUN
dti-1314	361	6	for	for	ADP
dti-1314	361	7	anticancer	anticancer	NOUN
dti-1314	361	8	therapeutics	therapeutic	NOUN
dti-1314	361	9	.	.	PUNCT
dti-1314	362	1	mol	mol	PROPN
dti-1314	362	2	.	.	PUNCT
dti-1314	363	1	cancer	cancer	NOUN
dti-1314	363	2	ther	ther	PROPN
dti-1314	363	3	.	.	PUNCT
dti-1314	363	4	,	,	PUNCT
dti-1314	364	1	4:677–85	4:677–85	PROPN
dti-1314	364	2	.	.	PUNCT
dti-1314	365	1	su	su	PROPN
dti-1314	365	2	,	,	PUNCT
dti-1314	365	3	t.s	t.s	PROPN
dti-1314	365	4	.	.	PROPN
dti-1314	365	5	,	,	PUNCT
dti-1314	365	6	bock	bock	NOUN
dti-1314	365	7	,	,	PUNCT
dti-1314	365	8	h.g	h.g	PROPN
dti-1314	365	9	.	.	PROPN
dti-1314	365	10	,	,	PUNCT
dti-1314	365	11	o’brien	o’brien	PROPN
dti-1314	365	12	,	,	PUNCT
dti-1314	365	13	w.e	w.e	PROPN
dti-1314	365	14	.	.	PROPN
dti-1314	365	15	et	et	PROPN
dti-1314	365	16	al	al	PROPN
dti-1314	365	17	.	.	PROPN
dti-1314	365	18	1981	1981	NUM
dti-1314	365	19	.	.	PUNCT
dti-1314	366	1	cloning	cloning	NOUN
dti-1314	366	2	of	of	ADP
dti-1314	366	3	cdna	cdna	PROPN
dti-1314	366	4	for	for	ADP
dti-1314	366	5	argininosuccinate	argininosuccinate	NOUN
dti-1314	366	6	synthetase	synthetase	NOUN
dti-1314	366	7	mrna	mrna	NOUN
dti-1314	366	8	and	and	CCONJ
dti-1314	366	9	study	study	NOUN
dti-1314	366	10	of	of	ADP
dti-1314	366	11	enzyme	enzyme	NOUN
dti-1314	366	12	over	over	ADP
dti-1314	366	13	production	production	NOUN
dti-1314	366	14	in	in	ADP
dti-1314	366	15	a	a	DET
dti-1314	366	16	human	human	ADJ
dti-1314	366	17	cell	cell	NOUN
dti-1314	366	18	line	line	NOUN
dti-1314	366	19	.	.	PUNCT
dti-1314	367	1	j.	j.	PROPN
dti-1314	367	2	biol	biol	PROPN
dti-1314	367	3	.	.	PUNCT
dti-1314	368	1	chem	chem	PROPN
dti-1314	368	2	.	.	PUNCT
dti-1314	368	3	,	,	PUNCT
dti-1314	369	1	256:11826–31	256:11826–31	PROPN
dti-1314	369	2	.	.	PUNCT
dti-1314	369	3	sugimura	sugimura	PROPN
dti-1314	369	4	,	,	PUNCT
dti-1314	369	5	k.	k.	PROPN
dti-1314	369	6	,	,	PUNCT
dti-1314	369	7	ohno	ohno	PROPN
dti-1314	369	8	,	,	PUNCT
dti-1314	369	9	t.	t.	PROPN
dti-1314	369	10	,	,	PUNCT
dti-1314	369	11	kusuyama	kusuyama	NOUN
dti-1314	369	12	,	,	PUNCT
dti-1314	369	13	t.	t.	PROPN
dti-1314	369	14	et	et	PROPN
dti-1314	369	15	al	al	PROPN
dti-1314	369	16	.	.	PROPN
dti-1314	369	17	1992	1992	NUM
dti-1314	369	18	.	.	PUNCT
dti-1314	370	1	high	high	ADJ
dti-1314	370	2	sensitivity	sensitivity	NOUN
dti-1314	370	3	of	of	ADP
dti-1314	370	4	human	human	ADJ
dti-1314	370	5	melanoma	melanoma	NOUN
dti-1314	370	6	cell	cell	NOUN
dti-1314	370	7	lines	line	NOUN
dti-1314	370	8	to	to	ADP
dti-1314	370	9	the	the	DET
dti-1314	370	10	growth	growth	NOUN
dti-1314	370	11	inhibitory	inhibitory	ADJ
dti-1314	370	12	activity	activity	NOUN
dti-1314	370	13	of	of	ADP
dti-1314	370	14	mycoplasmal	mycoplasmal	ADJ
dti-1314	370	15	arginine	arginine	NOUN
dti-1314	370	16	deiminase	deiminase	VERB
dti-1314	370	17	in	in	ADP
dti-1314	370	18	vitro	vitro	VERB
dti-1314	370	19	.	.	PUNCT
dti-1314	371	1	melanoma	melanoma	NOUN
dti-1314	371	2	.	.	PUNCT
dti-1314	372	1	res	re	NOUN
dti-1314	372	2	.	.	PROPN
dti-1314	372	3	,	,	PUNCT
dti-1314	372	4	2:191–6	2:191–6	NUM
dti-1314	372	5	szlosarek	szlosarek	NOUN
dti-1314	372	6	,	,	PUNCT
dti-1314	372	7	p.w	p.w	PROPN
dti-1314	372	8	.	.	PROPN
dti-1314	372	9	,	,	PUNCT
dti-1314	372	10	klabatsa	klabatsa	PROPN
dti-1314	372	11	,	,	PUNCT
dti-1314	372	12	a.	a.	NOUN
dti-1314	372	13	,	,	PUNCT
dti-1314	372	14	pallaska	pallaska	NOUN
dti-1314	372	15	,	,	PUNCT
dti-1314	372	16	a.	a.	PROPN
dti-1314	372	17	et	et	PROPN
dti-1314	372	18	al	al	PROPN
dti-1314	372	19	.	.	PROPN
dti-1314	372	20	2006	2006	NUM
dti-1314	372	21	.	.	PUNCT
dti-1314	373	1	in	in	ADP
dti-1314	373	2	vivo	vivo	ADJ
dti-1314	373	3	loss	loss	NOUN
dti-1314	373	4	of	of	ADP
dti-1314	373	5	expression	expression	NOUN
dti-1314	373	6	of	of	ADP
dti-1314	373	7	argininosuccinate	argininosuccinate	ADJ
dti-1314	373	8	synthetase	synthetase	NOUN
dti-1314	373	9	in	in	ADP
dti-1314	373	10	malignant	malignant	ADJ
dti-1314	373	11	pleural	pleural	ADJ
dti-1314	373	12	mesothelioma	mesothelioma	NOUN
dti-1314	373	13	is	be	AUX
dti-1314	373	14	a	a	DET
dti-1314	373	15	biomarker	biomarker	NOUN
dti-1314	373	16	for	for	ADP
dti-1314	373	17	susceptibility	susceptibility	NOUN
dti-1314	373	18	to	to	PART
dti-1314	373	19	arginine	arginine	VERB
dti-1314	373	20	depletion	depletion	NOUN
dti-1314	373	21	.	.	PUNCT
dti-1314	374	1	clin	clin	PROPN
dti-1314	374	2	.	.	PUNCT
dti-1314	375	1	cancer	cancer	NOUN
dti-1314	375	2	res	re	NOUN
dti-1314	375	3	.	.	PUNCT
dti-1314	375	4	,	,	PUNCT
dti-1314	375	5	12:7126–31	12:7126–31	PROPN
dti-1314	375	6	.	.	PROPN
dti-1314	375	7	128	128	NUM
dti-1314	375	8	savaraj	savaraj	VERB
dti-1314	375	9	et	et	PROPN
dti-1314	375	10	al	al	PROPN
dti-1314	375	11	drug	drug	PROPN
dti-1314	375	12	target	target	NOUN
dti-1314	375	13	insights	insight	NOUN
dti-1314	375	14	2007	2007	NUM
dti-1314	375	15	:	:	SYM
dti-1314	375	16	2	2	NUM
dti-1314	375	17	takaku	takaku	NOUN
dti-1314	375	18	,	,	PUNCT
dti-1314	375	19	h.	h.	PROPN
dti-1314	375	20	,	,	PUNCT
dti-1314	375	21	misawa	misawa	PROPN
dti-1314	375	22	,	,	PUNCT
dti-1314	375	23	s.	s.	PROPN
dti-1314	375	24	,	,	PUNCT
dti-1314	375	25	hayashi	hayashi	PROPN
dti-1314	375	26	,	,	PUNCT
dti-1314	375	27	h.	h.	PROPN
dti-1314	375	28	et	et	PROPN
dti-1314	375	29	al	al	PROPN
dti-1314	375	30	.	.	PROPN
dti-1314	375	31	1993	1993	NUM
dti-1314	375	32	.	.	PUNCT
dti-1314	376	1	chemical	chemical	PROPN
dti-1314	376	2	modifi	modifi	PROPN
dti-1314	376	3	cation	cation	NOUN
dti-1314	376	4	by	by	ADP
dti-1314	376	5	polyethylene	polyethylene	NOUN
dti-1314	376	6	glycol	glycol	NOUN
dti-1314	376	7	of	of	ADP
dti-1314	376	8	the	the	DET
dti-1314	376	9	anti	anti	ADJ
dti-1314	376	10	-	-	ADJ
dti-1314	376	11	tumor	tumor	ADJ
dti-1314	376	12	enzyme	enzyme	NOUN
dti-1314	376	13	arginine	arginine	NOUN
dti-1314	376	14	deiminase	deiminase	VERB
dti-1314	376	15	from	from	ADP
dti-1314	376	16	mycoplasma	mycoplasma	PROPN
dti-1314	376	17	arginini	arginini	PROPN
dti-1314	376	18	.	.	PUNCT
dti-1314	377	1	jpn	jpn	PROPN
dti-1314	377	2	.	.	PUNCT
dti-1314	378	1	j.	j.	PROPN
dti-1314	378	2	cancer	cancer	PROPN
dti-1314	378	3	res	re	NOUN
dti-1314	378	4	.	.	PROPN
dti-1314	378	5	,	,	PUNCT
dti-1314	378	6	84:1195–200	84:1195–200	PROPN
dti-1314	378	7	.	.	PUNCT
dti-1314	378	8	takaku	takaku	PROPN
dti-1314	378	9	,	,	PUNCT
dti-1314	378	10	h.	h.	PROPN
dti-1314	378	11	,	,	PUNCT
dti-1314	378	12	matsumoto	matsumoto	PROPN
dti-1314	378	13	,	,	PUNCT
dti-1314	378	14	m.	m.	NOUN
dti-1314	378	15	,	,	PUNCT
dti-1314	378	16	misawa	misawa	PROPN
dti-1314	378	17	,	,	PUNCT
dti-1314	378	18	s.	s.	PROPN
dti-1314	378	19	et	et	PROPN
dti-1314	378	20	al	al	PROPN
dti-1314	378	21	.	.	PROPN
dti-1314	378	22	1995	1995	NUM
dti-1314	378	23	.	.	PUNCT
dti-1314	379	1	anti	anti	ADJ
dti-1314	379	2	-	-	ADJ
dti-1314	379	3	tumor	tumor	ADJ
dti-1314	379	4	activity	activity	NOUN
dti-1314	379	5	of	of	ADP
dti-1314	379	6	arginine	arginine	NOUN
dti-1314	379	7	deiminase	deiminase	VERB
dti-1314	379	8	from	from	ADP
dti-1314	379	9	mycoplasma	mycoplasma	NOUN
dti-1314	379	10	argini	argini	NOUN
dti-1314	379	11	and	and	CCONJ
dti-1314	379	12	its	its	PRON
dti-1314	379	13	growth	growth	NOUN
dti-1314	379	14	-	-	PUNCT
dti-1314	379	15	inhibitory	inhibitory	ADJ
dti-1314	379	16	mechanism	mechanism	NOUN
dti-1314	379	17	.	.	PUNCT
dti-1314	380	1	jpn	jpn	PROPN
dti-1314	380	2	.	.	PUNCT
dti-1314	381	1	j.	j.	PROPN
dti-1314	381	2	cancer	cancer	PROPN
dti-1314	381	3	res	res	PROPN
dti-1314	381	4	.	.	PROPN
dti-1314	381	5	,	,	PUNCT
dti-1314	381	6	86:840–6	86:840–6	NUM
dti-1314	381	7	.	.	PUNCT
dti-1314	381	8	wheatley	wheatley	PROPN
dti-1314	381	9	,	,	PUNCT
dti-1314	381	10	d.n	d.n	PROPN
dti-1314	381	11	.	.	PROPN
dti-1314	381	12	and	and	CCONJ
dti-1314	381	13	campbell	campbell	PROPN
dti-1314	381	14	,	,	PUNCT
dti-1314	381	15	e.	e.	PROPN
dti-1314	381	16	2002	2002	NUM
dti-1314	381	17	.	.	PUNCT
dti-1314	382	1	arginine	arginine	PROPN
dti-1314	382	2	catabolism	catabolism	NOUN
dti-1314	382	3	,	,	PUNCT
dti-1314	382	4	liver	liver	NOUN
dti-1314	382	5	extracts	extract	NOUN
dti-1314	382	6	and	and	CCONJ
dti-1314	382	7	cancer	cancer	NOUN
dti-1314	382	8	.	.	PUNCT
dti-1314	383	1	pathol	pathol	NOUN
dti-1314	383	2	.	.	PUNCT
dti-1314	384	1	oncol	oncol	ADJ
dti-1314	384	2	.	.	PUNCT
dti-1314	385	1	res	re	NOUN
dti-1314	385	2	.	.	PROPN
dti-1314	385	3	,	,	PUNCT
dti-1314	385	4	8:18–25	8:18–25	NUM
dti-1314	385	5	.	.	PUNCT
dti-1314	386	1	wheatley	wheatley	PROPN
dti-1314	386	2	,	,	PUNCT
dti-1314	386	3	d.n	d.n	PROPN
dti-1314	386	4	.	.	PROPN
dti-1314	386	5	and	and	CCONJ
dti-1314	386	6	campbell	campbell	PROPN
dti-1314	386	7	,	,	PUNCT
dti-1314	386	8	e.	e.	PROPN
dti-1314	386	9	2003	2003	NUM
dti-1314	386	10	.	.	PUNCT
dti-1314	387	1	arginine	arginine	NOUN
dti-1314	387	2	deprivation	deprivation	NOUN
dti-1314	387	3	,	,	PUNCT
dti-1314	387	4	growth	growth	NOUN
dti-1314	387	5	inhibition	inhibition	NOUN
dti-1314	387	6	and	and	CCONJ
dti-1314	387	7	tumour	tumour	NOUN
dti-1314	387	8	cell	cell	NOUN
dti-1314	387	9	death	death	NOUN
dti-1314	387	10	:	:	PUNCT
dti-1314	387	11	3	3	X
dti-1314	387	12	.	.	X
dti-1314	387	13	defi	defi	PROPN
dti-1314	387	14	cient	cient	PROPN
dti-1314	387	15	utilization	utilization	NOUN
dti-1314	387	16	of	of	ADP
dti-1314	387	17	citrulline	citrulline	NOUN
dti-1314	387	18	by	by	ADP
dti-1314	387	19	malignant	malignant	ADJ
dti-1314	387	20	cells	cell	NOUN
dti-1314	387	21	.	.	PUNCT
dti-1314	388	1	br	br	PROPN
dti-1314	388	2	.	.	PUNCT
dti-1314	389	1	j.	j.	PROPN
dti-1314	389	2	cancer	cancer	PROPN
dti-1314	389	3	,	,	PUNCT
dti-1314	389	4	89:573–6	89:573–6	NUM
dti-1314	389	5	.	.	PUNCT
dti-1314	390	1	wheatley	wheatley	PROPN
dti-1314	390	2	,	,	PUNCT
dti-1314	390	3	d.n	d.n	PROPN
dti-1314	390	4	.	.	PROPN
dti-1314	390	5	2005	2005	NUM
dti-1314	390	6	.	.	PUNCT
dti-1314	391	1	arginine	arginine	NOUN
dti-1314	391	2	deprivation	deprivation	NOUN
dti-1314	391	3	and	and	CCONJ
dti-1314	391	4	metabolomics	metabolomic	NOUN
dti-1314	391	5	:	:	PUNCT
dti-1314	391	6	important	important	ADJ
dti-1314	391	7	aspects	aspect	NOUN
dti-1314	391	8	of	of	ADP
dti-1314	391	9	intermediary	intermediary	ADJ
dti-1314	391	10	metabolism	metabolism	NOUN
dti-1314	391	11	in	in	ADP
dti-1314	391	12	relation	relation	NOUN
dti-1314	391	13	to	to	ADP
dti-1314	391	14	the	the	DET
dti-1314	391	15	differential	differential	ADJ
dti-1314	391	16	sensitivity	sensitivity	NOUN
dti-1314	391	17	of	of	ADP
dti-1314	391	18	normal	normal	ADJ
dti-1314	391	19	and	and	CCONJ
dti-1314	391	20	tumour	tumour	NOUN
dti-1314	391	21	cells	cell	NOUN
dti-1314	391	22	.	.	PUNCT
dti-1314	392	1	semin	semin	PROPN
dti-1314	392	2	.	.	PUNCT
dti-1314	393	1	cancer	cancer	NOUN
dti-1314	393	2	biol	biol	PROPN
dti-1314	393	3	.	.	PUNCT
dti-1314	393	4	,	,	PUNCT
dti-1314	393	5	15:247–53	15:247–53	ADJ
dti-1314	393	6	.	.	PUNCT
dti-1314	394	1	yoon	yoon	PROPN
dti-1314	394	2	,	,	PUNCT
dti-1314	394	3	c.y	c.y	PROPN
dti-1314	394	4	.	.	PROPN
dti-1314	394	5	,	,	PUNCT
dti-1314	394	6	shim	shim	NOUN
dti-1314	394	7	,	,	PUNCT
dti-1314	394	8	y.j	y.j	PROPN
dti-1314	394	9	.	.	PROPN
dti-1314	394	10	,	,	PUNCT
dti-1314	394	11	kim	kim	PROPN
dti-1314	394	12	,	,	PUNCT
dti-1314	394	13	e.h	e.h	PROPN
dti-1314	394	14	.	.	PROPN
dti-1314	394	15	et	et	PROPN
dti-1314	394	16	al	al	PROPN
dti-1314	394	17	.	.	PROPN
dti-1314	394	18	2007	2007	NUM
dti-1314	394	19	.	.	PUNCT
dti-1314	395	1	renal	renal	ADJ
dti-1314	395	2	cell	cell	NOUN
dti-1314	395	3	carcinoma	carcinoma	NOUN
dti-1314	395	4	does	do	AUX
dti-1314	395	5	not	not	PART
dti-1314	395	6	express	express	VERB
dti-1314	395	7	argininosuccinate	argininosuccinate	NOUN
dti-1314	395	8	synthetase	synthetase	NOUN
dti-1314	395	9	and	and	CCONJ
dti-1314	395	10	is	be	AUX
dti-1314	395	11	highly	highly	ADV
dti-1314	395	12	sensitive	sensitive	ADJ
dti-1314	395	13	to	to	PART
dti-1314	395	14	arginine	arginine	VERB
dti-1314	395	15	deprivation	deprivation	NOUN
dti-1314	395	16	via	via	ADP
dti-1314	395	17	arginine	arginine	NOUN
dti-1314	395	18	deiminase	deiminase	PROPN
dti-1314	395	19	.	.	PUNCT
dti-1314	396	1	int	int	PROPN
dti-1314	396	2	.	.	PUNCT
dti-1314	397	1	j.	j.	PROPN
dti-1314	397	2	cancer	cancer	PROPN
dti-1314	397	3	,	,	PUNCT
dti-1314	397	4	120:897–905	120:897–905	NUM
dti-1314	397	5	.	.	PUNCT
dti-1314	398	1	<	<	X
dti-1314	398	2	<	<	X
dti-1314	398	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1314	398	4	false	false	ADJ
dti-1314	398	5	/allowtransparency	/allowtransparency	NOUN
dti-1314	398	6	false	false	ADJ
dti-1314	398	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1314	398	8	true	true	ADJ
dti-1314	398	9	/autorotatepages	/autorotatepage	NOUN
dti-1314	398	10	/none	/none	PUNCT
dti-1314	398	11	/binding	/binding	PUNCT
dti-1314	398	12	/left	/left	ADJ
dti-1314	399	1	/calgrayprofile	/calgrayprofile	VERB
dti-1314	399	2	(	(	PUNCT
dti-1314	399	3	dot	dot	NOUN
dti-1314	399	4	gain	gain	NOUN
dti-1314	399	5	20	20	NUM
dti-1314	399	6	%	%	NOUN
dti-1314	399	7	)	)	PUNCT
dti-1314	399	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1314	400	1	(	(	PUNCT
dti-1314	400	2	srgb	srgb	PROPN
dti-1314	400	3	iec61966	iec61966	NOUN
dti-1314	400	4	-	-	PUNCT
dti-1314	400	5	2.1	2.1	NUM
dti-1314	400	6	)	)	PUNCT
dti-1314	400	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1314	401	1	(	(	PUNCT
dti-1314	401	2	u.s	u.s	PROPN
dti-1314	401	3	.	.	PROPN
dti-1314	401	4	web	web	NOUN
dti-1314	401	5	coated	coat	VERB
dti-1314	401	6	\050swop\051	\050swop\051	ADJ
dti-1314	401	7	v2	v2	NOUN
dti-1314	401	8	)	)	PUNCT
dti-1314	401	9	/srgbprofile	/srgbprofile	PUNCT
dti-1314	401	10	(	(	PUNCT
dti-1314	401	11	srgb	srgb	PROPN
dti-1314	401	12	iec61966	iec61966	NOUN
dti-1314	401	13	-	-	PUNCT
dti-1314	401	14	2.1	2.1	NUM
dti-1314	401	15	)	)	PUNCT
dti-1314	401	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1314	402	1	/error	/error	INTJ
dti-1314	402	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1314	403	1	1.4	1.4	NUM
dti-1314	403	2	/compressobjects	/compressobject	NOUN
dti-1314	403	3	/tags	/tag	VERB
dti-1314	403	4	/compresspages	/compresspage	NOUN
dti-1314	403	5	true	true	ADJ
dti-1314	403	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1314	403	7	true	true	ADJ
dti-1314	403	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1314	403	9	true	true	ADJ
dti-1314	403	10	/createjdffile	/createjdffile	ADJ
dti-1314	403	11	false	false	ADJ
dti-1314	403	12	/createjobticket	/createjobticket	NOUN
dti-1314	403	13	false	false	ADJ
dti-1314	403	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1314	403	15	/default	/default	PUNCT
dti-1314	403	16	/detectblends	/detectblend	NOUN
dti-1314	403	17	true	true	ADJ
dti-1314	403	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1314	403	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1314	403	20	/dothumbnails	/dothumbnail	VERB
dti-1314	403	21	false	false	ADJ
dti-1314	403	22	/embedallfonts	/embedallfont	NOUN
dti-1314	403	23	true	true	ADJ
dti-1314	403	24	/embedjoboptions	/embedjoboption	NOUN
dti-1314	403	25	true	true	ADJ
dti-1314	403	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1314	403	27	0	0	NUM
dti-1314	403	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1314	403	29	false	false	ADJ
dti-1314	403	30	/endpage	/endpage	NOUN
dti-1314	403	31	-1	-1	NOUN
dti-1314	403	32	/imagememory	/imagememory	NUM
dti-1314	404	1	1048576	1048576	NUM
dti-1314	404	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1314	404	3	false	false	ADJ
dti-1314	404	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1314	404	5	100	100	NUM
dti-1314	404	6	/optimize	/optimize	NOUN
dti-1314	404	7	true	true	ADJ
dti-1314	404	8	/opm	/opm	NOUN
dti-1314	404	9	1	1	NUM
dti-1314	404	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1314	404	11	true	true	ADJ
dti-1314	404	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1314	404	13	true	true	ADJ
dti-1314	404	14	/preservecopypage	/preservecopypage	NOUN
dti-1314	404	15	true	true	ADJ
dti-1314	404	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1314	404	17	true	true	ADJ
dti-1314	404	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1314	404	19	false	false	ADJ
dti-1314	404	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1314	404	21	false	false	ADJ
dti-1314	404	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1314	404	23	true	true	ADJ
dti-1314	404	24	/startpage	/startpage	NOUN
dti-1314	404	25	1	1	NUM
dti-1314	404	26	/subsetfonts	/subsetfont	NOUN
dti-1314	404	27	true	true	ADJ
dti-1314	404	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1314	404	29	/apply	/apply	PUNCT
dti-1314	404	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1314	405	1	/preserve	/preserve	NOUN
dti-1314	405	2	/useprologue	/useprologue	NOUN
dti-1314	405	3	false	false	ADJ
dti-1314	405	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1314	405	5	(	(	PUNCT
dti-1314	405	6	)	)	PUNCT
dti-1314	405	7	/alwaysembed	/alwaysembe	VERB
dti-1314	405	8	[	[	PUNCT
dti-1314	405	9	true	true	ADJ
dti-1314	405	10	]	]	PUNCT
dti-1314	405	11	/neverembed	/neverembed	PUNCT
dti-1314	406	1	[	[	PUNCT
dti-1314	406	2	true	true	ADJ
dti-1314	406	3	]	]	PUNCT
dti-1314	406	4	/antialiascolorimages	/antialiascolorimages	X
dti-1314	406	5	false	false	ADJ
dti-1314	406	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1314	406	7	true	true	ADJ
dti-1314	406	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1314	406	9	/bicubic	/bicubic	NOUN
dti-1314	406	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1314	406	11	300	300	NUM
dti-1314	406	12	/colorimagedepth	/colorimagedepth	PRON
dti-1314	407	1	-1	-1	INTJ
dti-1314	407	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1314	407	3	1.50000	1.50000	NUM
dti-1314	407	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1314	407	5	true	true	ADJ
dti-1314	407	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1314	407	7	/dctencode	/dctencode	PUNCT
dti-1314	407	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1314	407	9	true	true	ADJ
dti-1314	407	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1314	407	11	/jpeg	/jpeg	PUNCT
dti-1314	407	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1314	408	1	<	<	X
dti-1314	408	2	<	<	X
dti-1314	408	3	/qfactor	/qfactor	NOUN
dti-1314	408	4	0.15	0.15	NUM
dti-1314	408	5	/hsamples	/hsample	NOUN
dti-1314	409	1	[	[	X
dti-1314	409	2	1	1	NUM
dti-1314	409	3	1	1	NUM
dti-1314	409	4	1	1	NUM
dti-1314	409	5	1	1	NUM
dti-1314	409	6	]	]	PUNCT
dti-1314	409	7	/vsamples	/vsample	NOUN
dti-1314	410	1	[	[	X
dti-1314	410	2	1	1	NUM
dti-1314	410	3	1	1	NUM
dti-1314	410	4	1	1	NUM
dti-1314	410	5	1	1	NUM
dti-1314	410	6	]	]	PUNCT
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dti-1314	434	3	>	>	X
dti-1314	434	4	/nld	/nld	PUNCT
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dti-1314	435	3	>	>	X
dti-1314	435	4	/esp	/esp	PUNCT
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dti-1314	436	3	>	>	X
dti-1314	436	4	/suo	/suo	PUNCT
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dti-1314	437	3	>	>	X
dti-1314	437	4	/ita	/ita	PUNCT
dti-1314	438	1	<	<	X
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dti-1314	438	3	>	>	X
dti-1314	438	4	/nor	/nor	X
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dti-1314	438	7	>	>	X
dti-1314	438	8	/sve	/sve	NOUN
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dti-1314	439	3	>	>	X
dti-1314	439	4	/enu	/enu	PROPN
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dti-1314	439	7	>	>	X
dti-1314	439	8	>	>	X
dti-1314	439	9	>	>	X
dti-1314	439	10	>	>	X
dti-1314	439	11	>	>	X
dti-1314	439	12	setdistillerparams	setdistillerparam	NOUN
dti-1314	440	1	<	<	X
dti-1314	440	2	<	<	X
dti-1314	440	3	/hwresolution	/hwresolution	NOUN
dti-1314	441	1	[	[	X
dti-1314	441	2	2400	2400	NUM
dti-1314	441	3	2400	2400	NUM
dti-1314	441	4	]	]	PUNCT
dti-1314	441	5	/pagesize	/pagesize	X
dti-1314	442	1	[	[	X
dti-1314	442	2	612.000	612.000	NUM
dti-1314	442	3	792.000	792.000	NUM
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dti-1314	442	5	>	>	PUNCT
dti-1314	442	6	>	>	X
dti-1314	442	7	setpagedevice	setpagedevice	PROPN