id	sid	tid	token	lemma	pos
dti-1318	1	1	tachedjian	tachedjian	PROPN
dti-1318	1	2	et	et	PROPN
dti-1318	1	3	al.indd	al.indd	X
dti-1318	1	4	drug	drug	NOUN
dti-1318	1	5	target	target	NOUN
dti-1318	1	6	insights	insight	NOUN
dti-1318	1	7	2007	2007	NUM
dti-1318	1	8	:	:	PUNCT
dti-1318	1	9	2	2	NUM
dti-1318	1	10	159–182	159–182	NUM
dti-1318	1	11	159	159	NUM
dti-1318	1	12	review	review	NOUN
dti-1318	1	13	correspondence	correspondence	NOUN
dti-1318	1	14	:	:	PUNCT
dti-1318	1	15	gilda	gilda	PROPN
dti-1318	1	16	tachedjian	tachedjian	PROPN
dti-1318	1	17	,	,	PUNCT
dti-1318	1	18	ph.d	ph.d	PROPN
dti-1318	1	19	.	.	PROPN
dti-1318	1	20	,	,	PUNCT
dti-1318	1	21	molecular	molecular	ADJ
dti-1318	1	22	interactions	interaction	NOUN
dti-1318	1	23	group	group	NOUN
dti-1318	1	24	,	,	PUNCT
dti-1318	1	25	the	the	DET
dti-1318	1	26	macfarlane	macfarlane	PROPN
dti-1318	1	27	burnet	burnet	PROPN
dti-1318	1	28	institute	institute	PROPN
dti-1318	1	29	for	for	ADP
dti-1318	1	30	medical	medical	ADJ
dti-1318	1	31	research	research	NOUN
dti-1318	1	32	and	and	CCONJ
dti-1318	1	33	public	public	ADJ
dti-1318	1	34	health	health	NOUN
dti-1318	1	35	,	,	PUNCT
dti-1318	1	36	gpo	gpo	NOUN
dti-1318	1	37	box	box	PROPN
dti-1318	1	38	2284	2284	NUM
dti-1318	1	39	,	,	PUNCT
dti-1318	1	40	melbourne	melbourne	PROPN
dti-1318	1	41	,	,	PUNCT
dti-1318	1	42	victoria	victoria	PROPN
dti-1318	1	43	,	,	PUNCT
dti-1318	1	44	3001	3001	NUM
dti-1318	1	45	,	,	PUNCT
dti-1318	1	46	australia	australia	PROPN
dti-1318	1	47	.	.	PUNCT
dti-1318	2	1	tel	tel	ADP
dti-1318	2	2	:	:	PUNCT
dti-1318	2	3	61	61	NUM
dti-1318	2	4	3	3	NUM
dti-1318	2	5	9282	9282	NUM
dti-1318	2	6	2256	2256	NUM
dti-1318	2	7	;	;	PUNCT
dti-1318	2	8	fax	fax	NOUN
dti-1318	2	9	:	:	PUNCT
dti-1318	2	10	61	61	NUM
dti-1318	2	11	3	3	NUM
dti-1318	2	12	9282	9282	NUM
dti-1318	2	13	2100	2100	NUM
dti-1318	2	14	;	;	PUNCT
dti-1318	2	15	email	email	NOUN
dti-1318	2	16	:	:	PUNCT
dti-1318	2	17	gildat@burnet.edu.au	gildat@burnet.edu.au	PROPN
dti-1318	2	18	please	please	INTJ
dti-1318	2	19	note	note	VERB
dti-1318	2	20	that	that	SCONJ
dti-1318	2	21	this	this	DET
dti-1318	2	22	article	article	NOUN
dti-1318	2	23	may	may	AUX
dti-1318	2	24	not	not	PART
dti-1318	2	25	be	be	AUX
dti-1318	2	26	used	use	VERB
dti-1318	2	27	for	for	ADP
dti-1318	2	28	commercial	commercial	ADJ
dti-1318	2	29	purposes	purpose	NOUN
dti-1318	2	30	.	.	PUNCT
dti-1318	3	1	for	for	ADP
dti-1318	3	2	further	further	ADJ
dti-1318	3	3	information	information	NOUN
dti-1318	3	4	please	please	INTJ
dti-1318	3	5	refer	refer	VERB
dti-1318	3	6	to	to	ADP
dti-1318	3	7	the	the	DET
dti-1318	3	8	copyright	copyright	NOUN
dti-1318	3	9	statement	statement	NOUN
dti-1318	3	10	at	at	ADP
dti-1318	3	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1318	3	12	targeting	target	VERB
dti-1318	3	13	human	human	ADJ
dti-1318	3	14	immunodefi	immunodefi	PROPN
dti-1318	3	15	ciency	ciency	NOUN
dti-1318	3	16	virus	virus	NOUN
dti-1318	3	17	type	type	NOUN
dti-1318	3	18	1	1	NUM
dti-1318	3	19	assembly	assembly	NOUN
dti-1318	3	20	,	,	PUNCT
dti-1318	3	21	maturation	maturation	NOUN
dti-1318	3	22	and	and	CCONJ
dti-1318	3	23	budding	bud	VERB
dti-1318	3	24	johanna	johanna	PROPN
dti-1318	3	25	wapling1,2	wapling1,2	PROPN
dti-1318	3	26	,	,	PUNCT
dti-1318	3	27	seema	seema	PROPN
dti-1318	3	28	srivastava1	srivastava1	PROPN
dti-1318	3	29	,	,	PUNCT
dti-1318	3	30	miranda	miranda	PROPN
dti-1318	3	31	shehu	shehu	PROPN
dti-1318	3	32	-	-	PUNCT
dti-1318	3	33	xhilaga3,4	xhilaga3,4	PROPN
dti-1318	3	34	and	and	CCONJ
dti-1318	3	35	gilda	gilda	PROPN
dti-1318	3	36	tachedjian1,2,3	tachedjian1,2,3	PROPN
dti-1318	3	37	1molecular	1molecular	NUM
dti-1318	3	38	interactions	interaction	NOUN
dti-1318	3	39	group	group	NOUN
dti-1318	3	40	,	,	PUNCT
dti-1318	3	41	macfarlane	macfarlane	PROPN
dti-1318	3	42	burnet	burnet	PROPN
dti-1318	3	43	institute	institute	PROPN
dti-1318	3	44	for	for	ADP
dti-1318	3	45	medical	medical	ADJ
dti-1318	3	46	research	research	NOUN
dti-1318	3	47	and	and	CCONJ
dti-1318	3	48	public	public	ADJ
dti-1318	3	49	health	health	NOUN
dti-1318	3	50	,	,	PUNCT
dti-1318	3	51	melbourne	melbourne	PROPN
dti-1318	3	52	,	,	PUNCT
dti-1318	3	53	victoria	victoria	PROPN
dti-1318	3	54	,	,	PUNCT
dti-1318	3	55	3004	3004	NUM
dti-1318	3	56	,	,	PUNCT
dti-1318	3	57	australia	australia	PROPN
dti-1318	3	58	.	.	PUNCT
dti-1318	4	1	2department	2department	NUM
dti-1318	4	2	of	of	ADP
dti-1318	4	3	microbiology	microbiology	NOUN
dti-1318	4	4	,	,	PUNCT
dti-1318	4	5	monash	monash	PROPN
dti-1318	4	6	university	university	PROPN
dti-1318	4	7	,	,	PUNCT
dti-1318	4	8	clayton	clayton	PROPN
dti-1318	4	9	,	,	PUNCT
dti-1318	4	10	victoria	victoria	PROPN
dti-1318	4	11	3168	3168	NUM
dti-1318	4	12	,	,	PUNCT
dti-1318	4	13	australia	australia	PROPN
dti-1318	4	14	.	.	PUNCT
dti-1318	5	1	3department	3department	NUM
dti-1318	5	2	of	of	ADP
dti-1318	5	3	medicine	medicine	NOUN
dti-1318	5	4	,	,	PUNCT
dti-1318	5	5	monash	monash	PROPN
dti-1318	5	6	university	university	PROPN
dti-1318	5	7	,	,	PUNCT
dti-1318	5	8	prahran	prahran	PROPN
dti-1318	5	9	,	,	PUNCT
dti-1318	5	10	victoria	victoria	PROPN
dti-1318	5	11	3181	3181	NUM
dti-1318	5	12	,	,	PUNCT
dti-1318	5	13	australia	australia	PROPN
dti-1318	5	14	.	.	PUNCT
dti-1318	6	1	4infectious	4infectious	NUM
dti-1318	6	2	diseases	disease	NOUN
dti-1318	6	3	unit	unit	NOUN
dti-1318	6	4	,	,	PUNCT
dti-1318	6	5	alfred	alfred	PROPN
dti-1318	6	6	hospital	hospital	PROPN
dti-1318	6	7	,	,	PUNCT
dti-1318	6	8	prahran	prahran	PROPN
dti-1318	6	9	,	,	PUNCT
dti-1318	6	10	victoria	victoria	PROPN
dti-1318	6	11	3181	3181	NUM
dti-1318	6	12	,	,	PUNCT
dti-1318	6	13	australia	australia	PROPN
dti-1318	6	14	.	.	PUNCT
dti-1318	7	1	abstract	abstract	ADJ
dti-1318	7	2	:	:	PUNCT
dti-1318	7	3	the	the	DET
dti-1318	7	4	targets	target	NOUN
dti-1318	7	5	for	for	ADP
dti-1318	7	6	licensed	licensed	ADJ
dti-1318	7	7	drugs	drug	NOUN
dti-1318	7	8	used	use	VERB
dti-1318	7	9	for	for	ADP
dti-1318	7	10	the	the	DET
dti-1318	7	11	treatment	treatment	NOUN
dti-1318	7	12	of	of	ADP
dti-1318	7	13	human	human	ADJ
dti-1318	7	14	immunodefi	immunodefi	PROPN
dti-1318	7	15	ciency	ciency	NOUN
dti-1318	7	16	virus	virus	NOUN
dti-1318	7	17	type	type	NOUN
dti-1318	7	18	1	1	NUM
dti-1318	7	19	(	(	PUNCT
dti-1318	7	20	hiv-1	hiv-1	X
dti-1318	7	21	)	)	PUNCT
dti-1318	7	22	are	be	AUX
dti-1318	7	23	confi	confi	ADJ
dti-1318	7	24	ned	ned	ADJ
dti-1318	7	25	to	to	ADP
dti-1318	7	26	the	the	DET
dti-1318	7	27	viral	viral	ADJ
dti-1318	7	28	reverse	reverse	ADJ
dti-1318	7	29	transcriptase	transcriptase	NOUN
dti-1318	7	30	(	(	PUNCT
dti-1318	7	31	rt	rt	NOUN
dti-1318	7	32	)	)	PUNCT
dti-1318	7	33	,	,	PUNCT
dti-1318	7	34	protease	protease	NOUN
dti-1318	7	35	(	(	PUNCT
dti-1318	7	36	pr	pr	NOUN
dti-1318	7	37	)	)	PUNCT
dti-1318	7	38	,	,	PUNCT
dti-1318	7	39	and	and	CCONJ
dti-1318	7	40	the	the	DET
dti-1318	7	41	gp41	gp41	PROPN
dti-1318	7	42	transmembrane	transmembrane	NOUN
dti-1318	7	43	protein	protein	NOUN
dti-1318	7	44	(	(	PUNCT
dti-1318	7	45	tm	tm	NOUN
dti-1318	7	46	)	)	PUNCT
dti-1318	7	47	.	.	PUNCT
dti-1318	8	1	while	while	SCONJ
dti-1318	8	2	currently	currently	ADV
dti-1318	8	3	approved	approve	VERB
dti-1318	8	4	drugs	drug	NOUN
dti-1318	8	5	are	be	AUX
dti-1318	8	6	effective	effective	ADJ
dti-1318	8	7	in	in	ADP
dti-1318	8	8	controlling	control	VERB
dti-1318	8	9	hiv-1	hiv-1	NOUN
dti-1318	8	10	infections	infection	NOUN
dti-1318	8	11	,	,	PUNCT
dti-1318	8	12	new	new	ADJ
dti-1318	8	13	drug	drug	NOUN
dti-1318	8	14	targets	target	NOUN
dti-1318	8	15	and	and	CCONJ
dti-1318	8	16	agents	agent	NOUN
dti-1318	8	17	are	be	AUX
dti-1318	8	18	needed	need	VERB
dti-1318	8	19	due	due	ADP
dti-1318	8	20	to	to	ADP
dti-1318	8	21	the	the	DET
dti-1318	8	22	eventual	eventual	ADJ
dti-1318	8	23	emergence	emergence	NOUN
dti-1318	8	24	of	of	ADP
dti-1318	8	25	drug	drug	NOUN
dti-1318	8	26	resistant	resistant	ADJ
dti-1318	8	27	strains	strain	NOUN
dti-1318	8	28	and	and	CCONJ
dti-1318	8	29	drug	drug	NOUN
dti-1318	8	30	toxicity	toxicity	NOUN
dti-1318	8	31	.	.	PUNCT
dti-1318	9	1	our	our	PRON
dti-1318	9	2	increased	increase	VERB
dti-1318	9	3	understanding	understanding	NOUN
dti-1318	9	4	of	of	ADP
dti-1318	9	5	the	the	DET
dti-1318	9	6	virus	virus	NOUN
dti-1318	9	7	life	life	NOUN
dti-1318	9	8	-	-	PUNCT
dti-1318	9	9	cycle	cycle	NOUN
dti-1318	9	10	and	and	CCONJ
dti-1318	9	11	how	how	SCONJ
dti-1318	9	12	the	the	DET
dti-1318	9	13	virus	virus	NOUN
dti-1318	9	14	interacts	interact	VERB
dti-1318	9	15	with	with	ADP
dti-1318	9	16	the	the	DET
dti-1318	9	17	host	host	NOUN
dti-1318	9	18	cell	cell	NOUN
dti-1318	9	19	has	have	AUX
dti-1318	9	20	unveiled	unveil	VERB
dti-1318	9	21	novel	novel	ADJ
dti-1318	9	22	mechanisms	mechanism	NOUN
dti-1318	9	23	for	for	ADP
dti-1318	9	24	blocking	block	VERB
dti-1318	9	25	hiv-1	hiv-1	X
dti-1318	9	26	replication	replication	NOUN
dti-1318	9	27	.	.	PUNCT
dti-1318	10	1	this	this	DET
dti-1318	10	2	review	review	NOUN
dti-1318	10	3	focuses	focus	VERB
dti-1318	10	4	on	on	ADP
dti-1318	10	5	inhibitors	inhibitor	NOUN
dti-1318	10	6	that	that	PRON
dti-1318	10	7	target	target	VERB
dti-1318	10	8	the	the	DET
dti-1318	10	9	late	late	ADJ
dti-1318	10	10	stages	stage	NOUN
dti-1318	10	11	of	of	ADP
dti-1318	10	12	virus	virus	NOUN
dti-1318	10	13	replication	replication	NOUN
dti-1318	10	14	including	include	VERB
dti-1318	10	15	the	the	DET
dti-1318	10	16	synthesis	synthesis	NOUN
dti-1318	10	17	and	and	CCONJ
dti-1318	10	18	traffi	traffi	NOUN
dti-1318	10	19	cking	cke	VERB
dti-1318	10	20	of	of	ADP
dti-1318	10	21	the	the	DET
dti-1318	10	22	viral	viral	ADJ
dti-1318	10	23	polyproteins	polyprotein	NOUN
dti-1318	10	24	,	,	PUNCT
dti-1318	10	25	viral	viral	ADJ
dti-1318	10	26	assembly	assembly	NOUN
dti-1318	10	27	,	,	PUNCT
dti-1318	10	28	maturation	maturation	NOUN
dti-1318	10	29	and	and	CCONJ
dti-1318	10	30	budding	budding	NOUN
dti-1318	10	31	.	.	PUNCT
dti-1318	11	1	novel	novel	ADJ
dti-1318	11	2	approaches	approach	NOUN
dti-1318	11	3	to	to	ADP
dti-1318	11	4	blocking	block	VERB
dti-1318	11	5	the	the	DET
dti-1318	11	6	oligomerization	oligomerization	NOUN
dti-1318	11	7	of	of	ADP
dti-1318	11	8	viral	viral	ADJ
dti-1318	11	9	enzymes	enzyme	NOUN
dti-1318	11	10	and	and	CCONJ
dti-1318	11	11	the	the	DET
dti-1318	11	12	interactions	interaction	NOUN
dti-1318	11	13	between	between	ADP
dti-1318	11	14	viral	viral	ADJ
dti-1318	11	15	proteins	protein	NOUN
dti-1318	11	16	and	and	CCONJ
dti-1318	11	17	host	host	NOUN
dti-1318	11	18	cell	cell	NOUN
dti-1318	11	19	factors	factor	NOUN
dti-1318	11	20	,	,	PUNCT
dti-1318	11	21	including	include	VERB
dti-1318	11	22	their	their	PRON
dti-1318	11	23	feasibility	feasibility	NOUN
dti-1318	11	24	as	as	ADP
dti-1318	11	25	drug	drug	NOUN
dti-1318	11	26	targets	target	NOUN
dti-1318	11	27	,	,	PUNCT
dti-1318	11	28	are	be	AUX
dti-1318	11	29	discussed	discuss	VERB
dti-1318	11	30	.	.	PUNCT
dti-1318	12	1	keywords	keyword	NOUN
dti-1318	12	2	:	:	PUNCT
dti-1318	12	3	hiv-1	hiv-1	X
dti-1318	12	4	,	,	PUNCT
dti-1318	12	5	antiretroviral	antiretroviral	ADJ
dti-1318	12	6	drugs	drug	NOUN
dti-1318	12	7	,	,	PUNCT
dti-1318	12	8	drug	drug	NOUN
dti-1318	12	9	targets	target	NOUN
dti-1318	12	10	,	,	PUNCT
dti-1318	12	11	assembly	assembly	NOUN
dti-1318	12	12	,	,	PUNCT
dti-1318	12	13	maturation	maturation	NOUN
dti-1318	12	14	,	,	PUNCT
dti-1318	12	15	budding	budding	NOUN
dti-1318	12	16	,	,	PUNCT
dti-1318	12	17	protease	protease	NOUN
dti-1318	12	18	dimerization	dimerization	NOUN
dti-1318	12	19	,	,	PUNCT
dti-1318	12	20	reverse	reverse	VERB
dti-1318	12	21	transcriptase	transcriptase	NOUN
dti-1318	12	22	dimerization	dimerization	NOUN
dti-1318	12	23	.	.	PUNCT
dti-1318	13	1	introduction	introduction	NOUN
dti-1318	13	2	hiv-1	hiv-1	PUNCT
dti-1318	13	3	is	be	AUX
dti-1318	13	4	a	a	DET
dti-1318	13	5	major	major	ADJ
dti-1318	13	6	public	public	ADJ
dti-1318	13	7	health	health	NOUN
dti-1318	13	8	problem	problem	NOUN
dti-1318	13	9	affecting	affect	VERB
dti-1318	13	10	an	an	DET
dti-1318	13	11	estimated	estimate	VERB
dti-1318	13	12	40	40	NUM
dti-1318	13	13	million	million	NUM
dti-1318	13	14	individuals	individual	NOUN
dti-1318	13	15	worldwide	worldwide	ADV
dti-1318	13	16	(	(	PUNCT
dti-1318	13	17	www	www	NOUN
dti-1318	13	18	.	.	PUNCT
dti-1318	13	19	unaids.org	unaids.org	X
dti-1318	13	20	)	)	PUNCT
dti-1318	13	21	.	.	PUNCT
dti-1318	14	1	although	although	SCONJ
dti-1318	14	2	it	it	PRON
dti-1318	14	3	has	have	AUX
dti-1318	14	4	been	be	AUX
dti-1318	14	5	over	over	ADP
dti-1318	14	6	20	20	NUM
dti-1318	14	7	years	year	NOUN
dti-1318	14	8	since	since	SCONJ
dti-1318	14	9	hiv-1	hiv-1	X
dti-1318	14	10	was	be	AUX
dti-1318	14	11	identifi	identifi	NOUN
dti-1318	14	12	ed	ed	NOUN
dti-1318	14	13	as	as	ADP
dti-1318	14	14	the	the	DET
dti-1318	14	15	etiologic	etiologic	ADJ
dti-1318	14	16	cause	cause	NOUN
dti-1318	14	17	of	of	ADP
dti-1318	14	18	acquired	acquire	VERB
dti-1318	14	19	immune	immune	ADJ
dti-1318	14	20	defi	defi	NOUN
dti-1318	14	21	ciency	ciency	NOUN
dti-1318	14	22	syndrome	syndrome	NOUN
dti-1318	14	23	(	(	PUNCT
dti-1318	14	24	aids	aids	PROPN
dti-1318	14	25	)	)	PUNCT
dti-1318	14	26	an	an	DET
dti-1318	14	27	effective	effective	ADJ
dti-1318	14	28	vaccine	vaccine	NOUN
dti-1318	14	29	is	be	AUX
dti-1318	14	30	not	not	PART
dti-1318	14	31	available	available	ADJ
dti-1318	14	32	.	.	PUNCT
dti-1318	15	1	thus	thus	ADV
dti-1318	15	2	,	,	PUNCT
dti-1318	15	3	apart	apart	ADV
dti-1318	15	4	from	from	ADP
dti-1318	15	5	public	public	ADJ
dti-1318	15	6	health	health	NOUN
dti-1318	15	7	measures	measure	NOUN
dti-1318	15	8	that	that	PRON
dti-1318	15	9	aim	aim	VERB
dti-1318	15	10	at	at	ADP
dti-1318	15	11	hiv-1	hiv-1	ADJ
dti-1318	15	12	prevention	prevention	NOUN
dti-1318	15	13	,	,	PUNCT
dti-1318	15	14	the	the	DET
dti-1318	15	15	only	only	ADJ
dti-1318	15	16	effective	effective	ADJ
dti-1318	15	17	strategy	strategy	NOUN
dti-1318	15	18	for	for	ADP
dti-1318	15	19	controlling	control	VERB
dti-1318	15	20	hiv-1	hiv-1	X
dti-1318	15	21	infections	infection	NOUN
dti-1318	15	22	and	and	CCONJ
dti-1318	15	23	lowering	lower	VERB
dti-1318	15	24	hiv-1	hiv-1	PUNCT
dti-1318	15	25	transmission	transmission	NOUN
dti-1318	15	26	is	be	AUX
dti-1318	15	27	the	the	DET
dti-1318	15	28	use	use	NOUN
dti-1318	15	29	of	of	ADP
dti-1318	15	30	antiretroviral	antiretroviral	ADJ
dti-1318	15	31	drugs	drug	NOUN
dti-1318	15	32	either	either	CCONJ
dti-1318	15	33	for	for	ADP
dti-1318	15	34	the	the	DET
dti-1318	15	35	treatment	treatment	NOUN
dti-1318	15	36	or	or	CCONJ
dti-1318	15	37	prevention	prevention	NOUN
dti-1318	15	38	of	of	ADP
dti-1318	15	39	infections	infection	NOUN
dti-1318	15	40	.	.	PUNCT
dti-1318	16	1	current	current	ADJ
dti-1318	16	2	antiretroviral	antiretroviral	ADJ
dti-1318	16	3	drugs	drug	NOUN
dti-1318	16	4	belong	belong	VERB
dti-1318	16	5	to	to	ADP
dti-1318	16	6	four	four	NUM
dti-1318	16	7	classes	class	NOUN
dti-1318	16	8	,	,	PUNCT
dti-1318	16	9	the	the	DET
dti-1318	16	10	nucleoside	nucleoside	NOUN
dti-1318	16	11	/	/	SYM
dti-1318	16	12	nucleotide	nucleotide	NOUN
dti-1318	16	13	reverse	reverse	NOUN
dti-1318	16	14	transcriptase	transcriptase	NOUN
dti-1318	16	15	inhibitors	inhibitor	NOUN
dti-1318	16	16	(	(	PUNCT
dti-1318	16	17	nrtis	nrtis	PROPN
dti-1318	16	18	)	)	PUNCT
dti-1318	16	19	,	,	PUNCT
dti-1318	16	20	nonnucleoside	nonnucleoside	ADV
dti-1318	16	21	reverse	reverse	ADJ
dti-1318	16	22	transcriptase	transcriptase	NOUN
dti-1318	16	23	inhibitors	inhibitor	NOUN
dti-1318	16	24	(	(	PUNCT
dti-1318	16	25	nnrtis	nnrtis	ADJ
dti-1318	16	26	)	)	PUNCT
dti-1318	16	27	,	,	PUNCT
dti-1318	16	28	protease	protease	NOUN
dti-1318	16	29	(	(	PUNCT
dti-1318	16	30	pr	pr	NOUN
dti-1318	16	31	)	)	PUNCT
dti-1318	16	32	inhibitors	inhibitor	NOUN
dti-1318	16	33	(	(	PUNCT
dti-1318	16	34	pi	pi	NOUN
dti-1318	16	35	)	)	PUNCT
dti-1318	16	36	and	and	CCONJ
dti-1318	16	37	fusion	fusion	NOUN
dti-1318	16	38	inhibitors	inhibitor	NOUN
dti-1318	16	39	(	(	PUNCT
dti-1318	16	40	vivet	vivet	NOUN
dti-1318	16	41	-	-	PUNCT
dti-1318	16	42	boudou	boudou	NOUN
dti-1318	16	43	et	et	PROPN
dti-1318	16	44	al	al	PROPN
dti-1318	16	45	.	.	PROPN
dti-1318	16	46	2006	2006	NUM
dti-1318	16	47	;	;	PUNCT
dti-1318	16	48	de	de	X
dti-1318	16	49	clercq	clercq	NOUN
dti-1318	16	50	,	,	PUNCT
dti-1318	16	51	1998	1998	NUM
dti-1318	16	52	;	;	PUNCT
dti-1318	16	53	abdel	abdel	PROPN
dti-1318	16	54	-	-	PUNCT
dti-1318	16	55	rahman	rahman	PROPN
dti-1318	16	56	et	et	PROPN
dti-1318	16	57	al	al	PROPN
dti-1318	16	58	.	.	PROPN
dti-1318	16	59	2002	2002	NUM
dti-1318	16	60	;	;	PUNCT
dti-1318	16	61	manfredi	manfredi	PROPN
dti-1318	16	62	and	and	CCONJ
dti-1318	16	63	sabbatani	sabbatani	PROPN
dti-1318	16	64	,	,	PUNCT
dti-1318	16	65	2006	2006	NUM
dti-1318	16	66	)	)	PUNCT
dti-1318	16	67	.	.	PUNCT
dti-1318	17	1	nrtis	nrtis	PROPN
dti-1318	17	2	and	and	CCONJ
dti-1318	17	3	nnrtis	nnrtis	PROPN
dti-1318	17	4	are	be	AUX
dti-1318	17	5	respectively	respectively	ADV
dti-1318	17	6	,	,	PUNCT
dti-1318	17	7	competitive	competitive	ADJ
dti-1318	17	8	and	and	CCONJ
dti-1318	17	9	allosteric	allosteric	ADJ
dti-1318	17	10	inhibitors	inhibitor	NOUN
dti-1318	17	11	of	of	ADP
dti-1318	17	12	the	the	DET
dti-1318	17	13	hiv-1	hiv-1	X
dti-1318	17	14	reverse	reverse	ADJ
dti-1318	17	15	transcriptase	transcriptase	NOUN
dti-1318	17	16	(	(	PUNCT
dti-1318	17	17	rt	rt	NOUN
dti-1318	17	18	)	)	PUNCT
dti-1318	17	19	and	and	CCONJ
dti-1318	17	20	act	act	VERB
dti-1318	17	21	early	early	ADV
dti-1318	17	22	in	in	ADP
dti-1318	17	23	the	the	DET
dti-1318	17	24	viral	viral	ADJ
dti-1318	17	25	life	life	NOUN
dti-1318	17	26	-	-	PUNCT
dti-1318	17	27	cycle	cycle	NOUN
dti-1318	17	28	by	by	ADP
dti-1318	17	29	blocking	block	VERB
dti-1318	17	30	the	the	DET
dti-1318	17	31	conversion	conversion	NOUN
dti-1318	17	32	of	of	ADP
dti-1318	17	33	the	the	DET
dti-1318	17	34	viral	viral	ADJ
dti-1318	17	35	rna	rna	NOUN
dti-1318	17	36	genome	genome	NOUN
dti-1318	17	37	into	into	ADP
dti-1318	17	38	a	a	DET
dti-1318	17	39	double	double	ADJ
dti-1318	17	40	stranded	strand	VERB
dti-1318	17	41	proviral	proviral	ADJ
dti-1318	17	42	dna	dna	NOUN
dti-1318	17	43	precursor	precursor	NOUN
dti-1318	17	44	(	(	PUNCT
dti-1318	17	45	shehu	shehu	NOUN
dti-1318	17	46	-	-	PUNCT
dti-1318	17	47	xhilaga	xhilaga	NOUN
dti-1318	17	48	et	et	PROPN
dti-1318	17	49	al	al	PROPN
dti-1318	17	50	.	.	PROPN
dti-1318	17	51	2005	2005	NUM
dti-1318	17	52	)	)	PUNCT
dti-1318	17	53	.	.	PUNCT
dti-1318	18	1	fuzeon	fuzeon	NOUN
dti-1318	18	2	(	(	PUNCT
dti-1318	18	3	enfuvirtide	enfuvirtide	ADJ
dti-1318	18	4	or	or	CCONJ
dti-1318	18	5	t20	t20	VERB
dti-1318	18	6	)	)	PUNCT
dti-1318	18	7	is	be	AUX
dti-1318	18	8	a	a	DET
dti-1318	18	9	peptide	peptide	NOUN
dti-1318	18	10	that	that	PRON
dti-1318	18	11	also	also	ADV
dti-1318	18	12	acts	act	VERB
dti-1318	18	13	early	early	ADV
dti-1318	18	14	in	in	ADP
dti-1318	18	15	the	the	DET
dti-1318	18	16	virus	virus	NOUN
dti-1318	18	17	life	life	NOUN
dti-1318	18	18	-	-	PUNCT
dti-1318	18	19	cycle	cycle	NOUN
dti-1318	18	20	by	by	ADP
dti-1318	18	21	preventing	prevent	VERB
dti-1318	18	22	viral	viral	ADJ
dti-1318	18	23	entry	entry	NOUN
dti-1318	18	24	through	through	ADP
dti-1318	18	25	interaction	interaction	NOUN
dti-1318	18	26	with	with	ADP
dti-1318	18	27	the	the	DET
dti-1318	18	28	gp41	gp41	PROPN
dti-1318	18	29	transmembrane	transmembrane	NOUN
dti-1318	18	30	protein	protein	NOUN
dti-1318	18	31	(	(	PUNCT
dti-1318	18	32	shehu	shehu	NOUN
dti-1318	18	33	-	-	PUNCT
dti-1318	18	34	xhilaga	xhilaga	NOUN
dti-1318	18	35	et	et	PROPN
dti-1318	18	36	al	al	PROPN
dti-1318	18	37	.	.	PROPN
dti-1318	18	38	2005	2005	NUM
dti-1318	18	39	)	)	PUNCT
dti-1318	18	40	.	.	PUNCT
dti-1318	19	1	in	in	ADP
dti-1318	19	2	contrast	contrast	NOUN
dti-1318	19	3	,	,	PUNCT
dti-1318	19	4	pis	pis	AUX
dti-1318	19	5	inhibit	inhibit	VERB
dti-1318	19	6	the	the	DET
dti-1318	19	7	late	late	ADJ
dti-1318	19	8	stage	stage	NOUN
dti-1318	19	9	of	of	ADP
dti-1318	19	10	virus	virus	NOUN
dti-1318	19	11	replication	replication	NOUN
dti-1318	19	12	by	by	ADP
dti-1318	19	13	blocking	block	VERB
dti-1318	19	14	the	the	DET
dti-1318	19	15	specifi	specifi	PROPN
dti-1318	19	16	c	c	PROPN
dti-1318	19	17	cleavage	cleavage	NOUN
dti-1318	19	18	of	of	ADP
dti-1318	19	19	gag	gag	NOUN
dti-1318	19	20	and	and	CCONJ
dti-1318	19	21	gag	gag	NOUN
dti-1318	19	22	-	-	PUNCT
dti-1318	19	23	pol	pol	NOUN
dti-1318	19	24	polyproteins	polyprotein	NOUN
dti-1318	19	25	to	to	PART
dti-1318	19	26	mature	mature	VERB
dti-1318	19	27	structural	structural	ADJ
dti-1318	19	28	proteins	protein	NOUN
dti-1318	19	29	and	and	CCONJ
dti-1318	19	30	enzymes	enzyme	NOUN
dti-1318	19	31	(	(	PUNCT
dti-1318	19	32	shehu	shehu	NOUN
dti-1318	19	33	-	-	PUNCT
dti-1318	19	34	xhilaga	xhilaga	NOUN
dti-1318	19	35	et	et	PROPN
dti-1318	19	36	al	al	PROPN
dti-1318	19	37	.	.	PROPN
dti-1318	19	38	2005	2005	NUM
dti-1318	19	39	)	)	PUNCT
dti-1318	19	40	.	.	PUNCT
dti-1318	20	1	early	early	ADJ
dti-1318	20	2	antiretroviral	antiretroviral	ADJ
dti-1318	20	3	regimens	regimen	NOUN
dti-1318	20	4	consisted	consist	VERB
dti-1318	20	5	of	of	ADP
dti-1318	20	6	one	one	NUM
dti-1318	20	7	or	or	CCONJ
dti-1318	20	8	two	two	NUM
dti-1318	20	9	rtis	rtis	NOUN
dti-1318	20	10	,	,	PUNCT
dti-1318	20	11	which	which	PRON
dti-1318	20	12	were	be	AUX
dti-1318	20	13	delivered	deliver	VERB
dti-1318	20	14	as	as	ADP
dti-1318	20	15	sequential	sequential	ADJ
dti-1318	20	16	monotherapy	monotherapy	NOUN
dti-1318	20	17	and	and	CCONJ
dti-1318	20	18	led	lead	VERB
dti-1318	20	19	to	to	ADP
dti-1318	20	20	treatment	treatment	NOUN
dti-1318	20	21	failure	failure	NOUN
dti-1318	20	22	(	(	PUNCT
dti-1318	20	23	piacenti	piacenti	NOUN
dti-1318	20	24	,	,	PUNCT
dti-1318	20	25	2006	2006	NUM
dti-1318	20	26	)	)	PUNCT
dti-1318	20	27	.	.	PUNCT
dti-1318	21	1	the	the	DET
dti-1318	21	2	advent	advent	NOUN
dti-1318	21	3	of	of	ADP
dti-1318	21	4	combination	combination	NOUN
dti-1318	21	5	therapy	therapy	NOUN
dti-1318	21	6	,	,	PUNCT
dti-1318	21	7	or	or	CCONJ
dti-1318	21	8	highly	highly	ADV
dti-1318	21	9	active	active	ADJ
dti-1318	21	10	antiretroviral	antiretroviral	ADJ
dti-1318	21	11	therapy	therapy	NOUN
dti-1318	21	12	(	(	PUNCT
dti-1318	21	13	haart	haart	PROPN
dti-1318	21	14	)	)	PUNCT
dti-1318	21	15	since	since	SCONJ
dti-1318	21	16	1996	1996	NUM
dti-1318	21	17	has	have	AUX
dti-1318	21	18	been	be	AUX
dti-1318	21	19	responsible	responsible	ADJ
dti-1318	21	20	for	for	ADP
dti-1318	21	21	a	a	DET
dti-1318	21	22	dramatic	dramatic	ADJ
dti-1318	21	23	decrease	decrease	NOUN
dti-1318	21	24	in	in	ADP
dti-1318	21	25	aids	aids	PROPN
dti-1318	21	26	mortality	mortality	NOUN
dti-1318	21	27	(	(	PUNCT
dti-1318	21	28	palella	palella	NOUN
dti-1318	21	29	et	et	PROPN
dti-1318	21	30	al	al	PROPN
dti-1318	21	31	.	.	PROPN
dti-1318	21	32	1998	1998	NUM
dti-1318	21	33	)	)	PUNCT
dti-1318	21	34	.	.	PUNCT
dti-1318	22	1	current	current	ADJ
dti-1318	22	2	haart	haart	PROPN
dti-1318	22	3	regimens	regimen	NOUN
dti-1318	22	4	generally	generally	ADV
dti-1318	22	5	comprise	comprise	VERB
dti-1318	22	6	three	three	NUM
dti-1318	22	7	antiretroviral	antiretroviral	ADJ
dti-1318	22	8	drugs	drug	NOUN
dti-1318	22	9	,	,	PUNCT
dti-1318	22	10	usually	usually	ADV
dti-1318	22	11	two	two	NUM
dti-1318	22	12	nrtis	nrtis	NOUN
dti-1318	22	13	and	and	CCONJ
dti-1318	22	14	either	either	CCONJ
dti-1318	22	15	a	a	DET
dti-1318	22	16	pi	pi	NOUN
dti-1318	22	17	or	or	CCONJ
dti-1318	22	18	an	an	DET
dti-1318	22	19	nnrti	nnrti	NOUN
dti-1318	22	20	(	(	PUNCT
dti-1318	22	21	yeni	yeni	PROPN
dti-1318	22	22	et	et	PROPN
dti-1318	22	23	al	al	PROPN
dti-1318	22	24	.	.	PROPN
dti-1318	22	25	2002	2002	NUM
dti-1318	22	26	)	)	PUNCT
dti-1318	22	27	.	.	PUNCT
dti-1318	23	1	while	while	SCONJ
dti-1318	23	2	an	an	DET
dti-1318	23	3	armoury	armoury	NOUN
dti-1318	23	4	of	of	ADP
dti-1318	23	5	agents	agent	NOUN
dti-1318	23	6	is	be	AUX
dti-1318	23	7	available	available	ADJ
dti-1318	23	8	for	for	ADP
dti-1318	23	9	the	the	DET
dti-1318	23	10	treatment	treatment	NOUN
dti-1318	23	11	of	of	ADP
dti-1318	23	12	hiv-1	hiv-1	ADJ
dti-1318	23	13	patients	patient	NOUN
dti-1318	23	14	,	,	PUNCT
dti-1318	23	15	new	new	ADJ
dti-1318	23	16	drugs	drug	NOUN
dti-1318	23	17	and	and	CCONJ
dti-1318	23	18	drug	drug	NOUN
dti-1318	23	19	targets	target	NOUN
dti-1318	23	20	need	need	VERB
dti-1318	23	21	to	to	PART
dti-1318	23	22	be	be	AUX
dti-1318	23	23	identifi	identifi	PROPN
dti-1318	23	24	ed	ed	NOUN
dti-1318	23	25	due	due	ADP
dti-1318	23	26	to	to	ADP
dti-1318	23	27	drug	drug	NOUN
dti-1318	23	28	toxicity	toxicity	NOUN
dti-1318	23	29	and	and	CCONJ
dti-1318	23	30	the	the	DET
dti-1318	23	31	eventual	eventual	ADJ
dti-1318	23	32	emergence	emergence	NOUN
dti-1318	23	33	of	of	ADP
dti-1318	23	34	drug	drug	NOUN
dti-1318	23	35	resistant	resistant	ADJ
dti-1318	23	36	strains	strain	NOUN
dti-1318	23	37	to	to	ADP
dti-1318	23	38	current	current	ADJ
dti-1318	23	39	antiretroviral	antiretroviral	ADJ
dti-1318	23	40	inhibitors	inhibitor	NOUN
dti-1318	23	41	(	(	PUNCT
dti-1318	23	42	clavel	clavel	ADJ
dti-1318	23	43	and	and	CCONJ
dti-1318	23	44	hance	hance	PROPN
dti-1318	23	45	,	,	PUNCT
dti-1318	23	46	2004	2004	NUM
dti-1318	23	47	)	)	PUNCT
dti-1318	23	48	.	.	PUNCT
dti-1318	24	1	moreover	moreover	ADV
dti-1318	24	2	,	,	PUNCT
dti-1318	24	3	resistance	resistance	NOUN
dti-1318	24	4	to	to	ADP
dti-1318	24	5	one	one	NUM
dti-1318	24	6	drug	drug	NOUN
dti-1318	24	7	normally	normally	ADV
dti-1318	24	8	results	result	VERB
dti-1318	24	9	160	160	NUM
dti-1318	24	10	wapling	waple	VERB
dti-1318	24	11	et	et	PROPN
dti-1318	24	12	al	al	PROPN
dti-1318	24	13	drug	drug	PROPN
dti-1318	24	14	target	target	NOUN
dti-1318	24	15	insights	insight	NOUN
dti-1318	24	16	2007	2007	NUM
dti-1318	24	17	:	:	SYM
dti-1318	24	18	2	2	NUM
dti-1318	24	19	in	in	ADP
dti-1318	24	20	cross	cross	NOUN
dti-1318	24	21	-	-	NOUN
dti-1318	24	22	resistance	resistance	NOUN
dti-1318	24	23	to	to	ADP
dti-1318	24	24	inhibitors	inhibitor	NOUN
dti-1318	24	25	of	of	ADP
dti-1318	24	26	the	the	DET
dti-1318	24	27	same	same	ADJ
dti-1318	24	28	class	class	NOUN
dti-1318	24	29	,	,	PUNCT
dti-1318	24	30	rendering	render	VERB
dti-1318	24	31	a	a	DET
dti-1318	24	32	large	large	ADJ
dti-1318	24	33	number	number	NOUN
dti-1318	24	34	of	of	ADP
dti-1318	24	35	agents	agent	NOUN
dti-1318	24	36	to	to	ADP
dti-1318	24	37	limited	limit	VERB
dti-1318	24	38	clinical	clinical	ADJ
dti-1318	24	39	use	use	NOUN
dti-1318	24	40	(	(	PUNCT
dti-1318	24	41	clavel	clavel	ADJ
dti-1318	24	42	and	and	CCONJ
dti-1318	24	43	hance	hance	PROPN
dti-1318	24	44	,	,	PUNCT
dti-1318	24	45	2004	2004	NUM
dti-1318	24	46	)	)	PUNCT
dti-1318	24	47	.	.	PUNCT
dti-1318	25	1	therefore	therefore	ADV
dti-1318	25	2	,	,	PUNCT
dti-1318	25	3	the	the	DET
dti-1318	25	4	development	development	NOUN
dti-1318	25	5	or	or	CCONJ
dti-1318	25	6	availability	availability	NOUN
dti-1318	25	7	of	of	ADP
dti-1318	25	8	new	new	ADJ
dti-1318	25	9	drugs	drug	NOUN
dti-1318	25	10	such	such	ADJ
dti-1318	25	11	as	as	ADP
dti-1318	25	12	fuzeon	fuzeon	NOUN
dti-1318	25	13	,	,	PUNCT
dti-1318	25	14	the	the	DET
dti-1318	25	15	hiv-1	hiv-1	X
dti-1318	25	16	integrase	integrase	NOUN
dti-1318	25	17	inhibitor	inhibitor	NOUN
dti-1318	25	18	raltegravir	raltegravir	PROPN
dti-1318	25	19	(	(	PUNCT
dti-1318	25	20	mk-0518	mk-0518	PROPN
dti-1318	25	21	)	)	PUNCT
dti-1318	25	22	(	(	PUNCT
dti-1318	25	23	grinsztejn	grinsztejn	NOUN
dti-1318	25	24	et	et	PROPN
dti-1318	25	25	al	al	PROPN
dti-1318	25	26	.	.	PROPN
dti-1318	25	27	2007	2007	NUM
dti-1318	25	28	)	)	PUNCT
dti-1318	25	29	and	and	CCONJ
dti-1318	25	30	the	the	DET
dti-1318	25	31	ccr5	ccr5	NOUN
dti-1318	25	32	antagonist	antagonist	NOUN
dti-1318	25	33	maraviroc	maraviroc	NOUN
dti-1318	25	34	(	(	PUNCT
dti-1318	25	35	stephenson	stephenson	NOUN
dti-1318	25	36	,	,	PUNCT
dti-1318	25	37	2007	2007	NUM
dti-1318	25	38	)	)	PUNCT
dti-1318	25	39	that	that	PRON
dti-1318	25	40	remain	remain	VERB
dti-1318	25	41	active	active	ADJ
dti-1318	25	42	against	against	ADP
dti-1318	25	43	drug	drug	NOUN
dti-1318	25	44	resistant	resistant	ADJ
dti-1318	25	45	virus	virus	NOUN
dti-1318	25	46	is	be	AUX
dti-1318	25	47	essential	essential	ADJ
dti-1318	25	48	for	for	ADP
dti-1318	25	49	the	the	DET
dti-1318	25	50	continuing	continue	VERB
dti-1318	25	51	success	success	NOUN
dti-1318	25	52	of	of	ADP
dti-1318	25	53	haart	haart	PROPN
dti-1318	25	54	(	(	PUNCT
dti-1318	25	55	yeni	yeni	PROPN
dti-1318	25	56	,	,	PUNCT
dti-1318	25	57	2006	2006	NUM
dti-1318	25	58	)	)	PUNCT
dti-1318	25	59	.	.	PUNCT
dti-1318	26	1	the	the	DET
dti-1318	26	2	increased	increase	VERB
dti-1318	26	3	understanding	understanding	NOUN
dti-1318	26	4	of	of	ADP
dti-1318	26	5	how	how	SCONJ
dti-1318	26	6	hiv-1	hiv-1	DET
dti-1318	26	7	reproduces	reproduce	NOUN
dti-1318	26	8	and	and	CCONJ
dti-1318	26	9	interacts	interact	VERB
dti-1318	26	10	with	with	ADP
dti-1318	26	11	the	the	DET
dti-1318	26	12	host	host	NOUN
dti-1318	26	13	cell	cell	NOUN
dti-1318	26	14	machinery	machinery	NOUN
dti-1318	26	15	has	have	AUX
dti-1318	26	16	resulted	result	VERB
dti-1318	26	17	in	in	ADP
dti-1318	26	18	the	the	DET
dti-1318	26	19	identifi	identifi	NOUN
dti-1318	26	20	cation	cation	NOUN
dti-1318	26	21	of	of	ADP
dti-1318	26	22	potential	potential	ADJ
dti-1318	26	23	drug	drug	NOUN
dti-1318	26	24	targets	target	NOUN
dti-1318	26	25	,	,	PUNCT
dti-1318	26	26	which	which	PRON
dti-1318	26	27	can	can	AUX
dti-1318	26	28	be	be	AUX
dti-1318	26	29	exploited	exploit	VERB
dti-1318	26	30	for	for	ADP
dti-1318	26	31	the	the	DET
dti-1318	26	32	development	development	NOUN
dti-1318	26	33	of	of	ADP
dti-1318	26	34	new	new	ADJ
dti-1318	26	35	classes	class	NOUN
dti-1318	26	36	of	of	ADP
dti-1318	26	37	inhibitors	inhibitor	NOUN
dti-1318	26	38	.	.	PUNCT
dti-1318	27	1	here	here	ADV
dti-1318	27	2	we	we	PRON
dti-1318	27	3	describe	describe	VERB
dti-1318	27	4	strategies	strategy	NOUN
dti-1318	27	5	and	and	CCONJ
dti-1318	27	6	agents	agent	NOUN
dti-1318	27	7	that	that	PRON
dti-1318	27	8	block	block	VERB
dti-1318	27	9	the	the	DET
dti-1318	27	10	late	late	ADJ
dti-1318	27	11	stages	stage	NOUN
dti-1318	27	12	of	of	ADP
dti-1318	27	13	hiv-1	hiv-1	X
dti-1318	27	14	replication	replication	NOUN
dti-1318	27	15	including	include	VERB
dti-1318	27	16	the	the	DET
dti-1318	27	17	synthesis	synthesis	NOUN
dti-1318	27	18	and	and	CCONJ
dti-1318	27	19	traffi	traffi	NOUN
dti-1318	27	20	cking	cke	VERB
dti-1318	27	21	of	of	ADP
dti-1318	27	22	viral	viral	ADJ
dti-1318	27	23	polyproteins	polyprotein	NOUN
dti-1318	27	24	,	,	PUNCT
dti-1318	27	25	viral	viral	ADJ
dti-1318	27	26	assembly	assembly	NOUN
dti-1318	27	27	,	,	PUNCT
dti-1318	27	28	maturation	maturation	NOUN
dti-1318	27	29	and	and	CCONJ
dti-1318	27	30	budding	budding	NOUN
dti-1318	27	31	.	.	PUNCT
dti-1318	28	1	novel	novel	ADJ
dti-1318	28	2	approaches	approach	NOUN
dti-1318	28	3	to	to	ADP
dti-1318	28	4	blocking	block	VERB
dti-1318	28	5	the	the	DET
dti-1318	28	6	oligomerization	oligomerization	NOUN
dti-1318	28	7	of	of	ADP
dti-1318	28	8	viral	viral	ADJ
dti-1318	28	9	enzymes	enzyme	NOUN
dti-1318	28	10	and	and	CCONJ
dti-1318	28	11	the	the	DET
dti-1318	28	12	interactions	interaction	NOUN
dti-1318	28	13	between	between	ADP
dti-1318	28	14	viral	viral	ADJ
dti-1318	28	15	proteins	protein	NOUN
dti-1318	28	16	and	and	CCONJ
dti-1318	28	17	host	host	NOUN
dti-1318	28	18	cell	cell	NOUN
dti-1318	28	19	factors	factor	NOUN
dti-1318	28	20	are	be	AUX
dti-1318	28	21	discussed	discuss	VERB
dti-1318	28	22	including	include	VERB
dti-1318	28	23	their	their	PRON
dti-1318	28	24	feasibility	feasibility	NOUN
dti-1318	28	25	as	as	ADP
dti-1318	28	26	drug	drug	NOUN
dti-1318	28	27	targets	target	NOUN
dti-1318	28	28	.	.	PUNCT
dti-1318	29	1	while	while	SCONJ
dti-1318	29	2	peptidomimetic	peptidomimetic	ADJ
dti-1318	29	3	pis	pis	NOUN
dti-1318	29	4	act	act	NOUN
dti-1318	29	5	at	at	ADP
dti-1318	29	6	the	the	DET
dti-1318	29	7	late	late	ADJ
dti-1318	29	8	stage	stage	NOUN
dti-1318	29	9	of	of	ADP
dti-1318	29	10	hiv-1	hiv-1	X
dti-1318	29	11	replication	replication	NOUN
dti-1318	29	12	to	to	PART
dti-1318	29	13	block	block	VERB
dti-1318	29	14	viral	viral	ADJ
dti-1318	29	15	maturation	maturation	NOUN
dti-1318	29	16	,	,	PUNCT
dti-1318	29	17	this	this	DET
dti-1318	29	18	review	review	NOUN
dti-1318	29	19	will	will	AUX
dti-1318	29	20	deal	deal	VERB
dti-1318	29	21	with	with	ADP
dti-1318	29	22	agents	agent	NOUN
dti-1318	29	23	that	that	PRON
dti-1318	29	24	inhibit	inhibit	VERB
dti-1318	29	25	hiv-1	hiv-1	PUNCT
dti-1318	29	26	pr	pr	NOUN
dti-1318	29	27	by	by	ADP
dti-1318	29	28	novel	novel	ADJ
dti-1318	29	29	mechanisms	mechanism	NOUN
dti-1318	29	30	that	that	PRON
dti-1318	29	31	are	be	AUX
dti-1318	29	32	distinct	distinct	ADJ
dti-1318	29	33	to	to	ADP
dti-1318	29	34	these	these	DET
dti-1318	29	35	transition	transition	NOUN
dti-1318	29	36	state	state	NOUN
dti-1318	29	37	mimetics	mimetic	NOUN
dti-1318	29	38	that	that	PRON
dti-1318	29	39	are	be	AUX
dti-1318	29	40	competitive	competitive	ADJ
dti-1318	29	41	inhibitors	inhibitor	NOUN
dti-1318	29	42	of	of	ADP
dti-1318	29	43	the	the	DET
dti-1318	29	44	hiv-1	hiv-1	ADJ
dti-1318	29	45	pr	pr	NOUN
dti-1318	29	46	.	.	PUNCT
dti-1318	30	1	late	late	ADJ
dti-1318	30	2	stages	stage	NOUN
dti-1318	30	3	of	of	ADP
dti-1318	30	4	the	the	DET
dti-1318	30	5	hiv-1	hiv-1	X
dti-1318	30	6	life	life	NOUN
dti-1318	30	7	cycle	cycle	NOUN
dti-1318	30	8	following	follow	VERB
dti-1318	30	9	virus	virus	NOUN
dti-1318	30	10	attachment	attachment	NOUN
dti-1318	30	11	,	,	PUNCT
dti-1318	30	12	fusion	fusion	NOUN
dti-1318	30	13	and	and	CCONJ
dti-1318	30	14	uncoating	uncoate	VERB
dti-1318	30	15	the	the	DET
dti-1318	30	16	single	single	ADJ
dti-1318	30	17	stranded	strand	VERB
dti-1318	30	18	positive	positive	ADJ
dti-1318	30	19	sense	sense	NOUN
dti-1318	30	20	rna	rna	NOUN
dti-1318	30	21	genome	genome	NOUN
dti-1318	30	22	of	of	ADP
dti-1318	30	23	hiv-1	hiv-1	PUNCT
dti-1318	30	24	is	be	AUX
dti-1318	30	25	reverse	reverse	ADJ
dti-1318	30	26	transcribed	transcribe	VERB
dti-1318	30	27	by	by	ADP
dti-1318	30	28	the	the	DET
dti-1318	30	29	viral	viral	ADJ
dti-1318	30	30	rt	rt	NOUN
dti-1318	30	31	into	into	ADP
dti-1318	30	32	a	a	DET
dti-1318	30	33	proviral	proviral	ADJ
dti-1318	30	34	dna	dna	NOUN
dti-1318	30	35	precursor	precursor	NOUN
dti-1318	30	36	in	in	ADP
dti-1318	30	37	a	a	DET
dti-1318	30	38	reverse	reverse	ADJ
dti-1318	30	39	transcription	transcription	NOUN
dti-1318	30	40	complex	complex	NOUN
dti-1318	30	41	(	(	PUNCT
dti-1318	30	42	rtc	rtc	PROPN
dti-1318	30	43	)	)	PUNCT
dti-1318	30	44	containing	contain	VERB
dti-1318	30	45	viral	viral	ADJ
dti-1318	30	46	and	and	CCONJ
dti-1318	30	47	possibly	possibly	ADV
dti-1318	30	48	host	host	NOUN
dti-1318	30	49	cell	cell	NOUN
dti-1318	30	50	factors	factor	NOUN
dti-1318	30	51	(	(	PUNCT
dti-1318	30	52	fig	fig	NOUN
dti-1318	30	53	.	.	PUNCT
dti-1318	31	1	1	1	NUM
dti-1318	31	2	)	)	PUNCT
dti-1318	31	3	.	.	PUNCT
dti-1318	32	1	the	the	DET
dti-1318	32	2	rtc	rtc	PROPN
dti-1318	32	3	matures	mature	NOUN
dti-1318	32	4	into	into	ADP
dti-1318	32	5	a	a	DET
dti-1318	32	6	preintegration	preintegration	NOUN
dti-1318	32	7	complex	complex	NOUN
dti-1318	32	8	(	(	PUNCT
dti-1318	32	9	pic	pic	NOUN
dti-1318	32	10	)	)	PUNCT
dti-1318	32	11	and	and	CCONJ
dti-1318	32	12	traffi	traffi	PROPN
dti-1318	32	13	cs	cs	PROPN
dti-1318	32	14	to	to	ADP
dti-1318	32	15	the	the	DET
dti-1318	32	16	nucleus	nucleus	NOUN
dti-1318	32	17	where	where	SCONJ
dti-1318	32	18	the	the	DET
dti-1318	32	19	viral	viral	ADJ
dti-1318	32	20	cdna	cdna	PROPN
dti-1318	32	21	is	be	AUX
dti-1318	32	22	inserted	insert	VERB
dti-1318	32	23	into	into	ADP
dti-1318	32	24	the	the	DET
dti-1318	32	25	host	host	NOUN
dti-1318	32	26	cell	cell	NOUN
dti-1318	32	27	chromosome	chromosome	NOUN
dti-1318	32	28	by	by	ADP
dti-1318	32	29	the	the	DET
dti-1318	32	30	hiv-1	hiv-1	ADJ
dti-1318	32	31	integrase	integrase	NOUN
dti-1318	32	32	(	(	PUNCT
dti-1318	32	33	in	in	ADP
dti-1318	32	34	)	)	PUNCT
dti-1318	32	35	(	(	PUNCT
dti-1318	32	36	telesnitsky	telesnitsky	NOUN
dti-1318	32	37	a.	a.	PROPN
dti-1318	32	38	and	and	CCONJ
dti-1318	32	39	goff	goff	PROPN
dti-1318	32	40	,	,	PUNCT
dti-1318	32	41	1997	1997	NUM
dti-1318	32	42	)	)	PUNCT
dti-1318	32	43	.	.	PUNCT
dti-1318	33	1	the	the	DET
dti-1318	33	2	processes	process	NOUN
dti-1318	33	3	from	from	ADP
dti-1318	33	4	entry	entry	NOUN
dti-1318	33	5	up	up	ADP
dti-1318	33	6	to	to	ADP
dti-1318	33	7	and	and	CCONJ
dti-1318	33	8	including	include	VERB
dti-1318	33	9	integration	integration	NOUN
dti-1318	33	10	are	be	AUX
dti-1318	33	11	defi	defi	NOUN
dti-1318	33	12	ned	ned	NOUN
dti-1318	33	13	as	as	ADP
dti-1318	33	14	the	the	DET
dti-1318	33	15	early	early	ADJ
dti-1318	33	16	steps	step	NOUN
dti-1318	33	17	in	in	ADP
dti-1318	33	18	the	the	DET
dti-1318	33	19	viral	viral	ADJ
dti-1318	33	20	life	life	NOUN
dti-1318	33	21	cycle	cycle	NOUN
dti-1318	33	22	.	.	PUNCT
dti-1318	34	1	the	the	DET
dti-1318	34	2	late	late	ADJ
dti-1318	34	3	stage	stage	NOUN
dti-1318	34	4	of	of	ADP
dti-1318	34	5	virus	virus	NOUN
dti-1318	34	6	replication	replication	NOUN
dti-1318	34	7	begins	begin	VERB
dti-1318	34	8	with	with	ADP
dti-1318	34	9	transcription	transcription	NOUN
dti-1318	34	10	of	of	ADP
dti-1318	34	11	the	the	DET
dti-1318	34	12	viral	viral	ADJ
dti-1318	34	13	mrnas	mrna	NOUN
dti-1318	34	14	from	from	ADP
dti-1318	34	15	the	the	DET
dti-1318	34	16	integrated	integrate	VERB
dti-1318	34	17	provirus	provirus	NOUN
dti-1318	34	18	(	(	PUNCT
dti-1318	34	19	fig.1	fig.1	PROPN
dti-1318	34	20	)	)	PUNCT
dti-1318	34	21	.	.	PUNCT
dti-1318	35	1	singly	singly	ADV
dti-1318	35	2	and	and	CCONJ
dti-1318	35	3	multiply	multiply	ADV
dti-1318	35	4	spliced	splice	VERB
dti-1318	35	5	mrnas	mrna	NOUN
dti-1318	35	6	encode	encode	VERB
dti-1318	35	7	the	the	DET
dti-1318	35	8	hiv-1	hiv-1	X
dti-1318	35	9	envelope	envelope	NOUN
dti-1318	35	10	proteins	protein	NOUN
dti-1318	35	11	and	and	CCONJ
dti-1318	35	12	regulatory	regulatory	ADJ
dti-1318	35	13	/	/	SYM
dti-1318	35	14	accessory	accessory	ADJ
dti-1318	35	15	proteins	protein	NOUN
dti-1318	35	16	,	,	PUNCT
dti-1318	35	17	respectively	respectively	ADV
dti-1318	35	18	(	(	PUNCT
dti-1318	35	19	rabson	rabson	NOUN
dti-1318	35	20	and	and	CCONJ
dti-1318	35	21	graves	grave	NOUN
dti-1318	35	22	,	,	PUNCT
dti-1318	35	23	1997	1997	NUM
dti-1318	35	24	)	)	PUNCT
dti-1318	35	25	.	.	PUNCT
dti-1318	36	1	pr55gag	pr55gag	NOUN
dti-1318	36	2	(	(	PUNCT
dti-1318	36	3	gag	gag	NOUN
dti-1318	36	4	)	)	PUNCT
dti-1318	36	5	and	and	CCONJ
dti-1318	36	6	pr160gag	pr160gag	NOUN
dti-1318	36	7	-	-	PUNCT
dti-1318	36	8	pol	pol	NOUN
dti-1318	36	9	(	(	PUNCT
dti-1318	36	10	gag	gag	NOUN
dti-1318	36	11	-	-	PUNCT
dti-1318	36	12	pol	pol	NOUN
dti-1318	36	13	)	)	PUNCT
dti-1318	36	14	polyproteins	polyprotein	NOUN
dti-1318	36	15	are	be	AUX
dti-1318	36	16	translated	translate	VERB
dti-1318	36	17	from	from	ADP
dti-1318	36	18	unspliced	unspliced	ADJ
dti-1318	36	19	mrnas	mrna	NOUN
dti-1318	36	20	(	(	PUNCT
dti-1318	36	21	swanstrom	swanstrom	NOUN
dti-1318	36	22	,	,	PUNCT
dti-1318	36	23	1997	1997	NUM
dti-1318	36	24	)	)	PUNCT
dti-1318	36	25	.	.	PUNCT
dti-1318	37	1	formation	formation	NOUN
dti-1318	37	2	of	of	ADP
dti-1318	37	3	two	two	NUM
dti-1318	37	4	types	type	NOUN
dti-1318	37	5	of	of	ADP
dti-1318	37	6	polyproteins	polyprotein	NOUN
dti-1318	37	7	from	from	ADP
dti-1318	37	8	the	the	DET
dti-1318	37	9	same	same	ADJ
dti-1318	37	10	unspliced	unspliced	ADJ
dti-1318	37	11	mrna	mrna	PROPN
dti-1318	37	12	is	be	AUX
dti-1318	37	13	mediated	mediate	VERB
dti-1318	37	14	by	by	ADP
dti-1318	37	15	a	a	DET
dti-1318	37	16	ribosomal	ribosomal	ADJ
dti-1318	37	17	frameshifting	frameshifte	VERB
dti-1318	37	18	mechanism	mechanism	NOUN
dti-1318	37	19	that	that	PRON
dti-1318	37	20	brings	bring	VERB
dti-1318	37	21	the	the	DET
dti-1318	37	22	pol	pol	NOUN
dti-1318	37	23	sequence	sequence	NOUN
dti-1318	37	24	in	in	ADP
dti-1318	37	25	the	the	DET
dti-1318	37	26	same	same	ADJ
dti-1318	37	27	reading	reading	NOUN
dti-1318	37	28	frame	frame	NOUN
dti-1318	37	29	as	as	ADP
dti-1318	37	30	gag	gag	NOUN
dti-1318	37	31	.	.	PUNCT
dti-1318	38	1	perturbation	perturbation	NOUN
dti-1318	38	2	of	of	ADP
dti-1318	38	3	ribosomal	ribosomal	NOUN
dti-1318	38	4	frameshifting	frameshifting	NOUN
dti-1318	38	5	leads	lead	VERB
dti-1318	38	6	to	to	ADP
dti-1318	38	7	changes	change	NOUN
dti-1318	38	8	in	in	ADP
dti-1318	38	9	the	the	DET
dti-1318	38	10	gag	gag	NOUN
dti-1318	38	11	and	and	CCONJ
dti-1318	38	12	gag	gag	NOUN
dti-1318	38	13	-	-	PUNCT
dti-1318	38	14	pol	pol	NOUN
dti-1318	38	15	ratio	ratio	NOUN
dti-1318	38	16	that	that	PRON
dti-1318	38	17	is	be	AUX
dti-1318	38	18	detrimental	detrimental	ADJ
dti-1318	38	19	to	to	ADP
dti-1318	38	20	virus	virus	NOUN
dti-1318	38	21	assembly	assembly	NOUN
dti-1318	38	22	,	,	PUNCT
dti-1318	38	23	morphogenesis	morphogenesis	NOUN
dti-1318	38	24	and	and	CCONJ
dti-1318	38	25	release	release	NOUN
dti-1318	38	26	(	(	PUNCT
dti-1318	38	27	swanstrom	swanstrom	NOUN
dti-1318	38	28	,	,	PUNCT
dti-1318	38	29	1997	1997	NUM
dti-1318	38	30	)	)	PUNCT
dti-1318	38	31	.	.	PUNCT
dti-1318	39	1	gag	gag	NOUN
dti-1318	39	2	encodes	encode	VERB
dti-1318	39	3	the	the	DET
dti-1318	39	4	viral	viral	ADJ
dti-1318	39	5	structural	structural	ADJ
dti-1318	39	6	proteins	protein	NOUN
dti-1318	39	7	matrix	matrix	NOUN
dti-1318	39	8	(	(	PUNCT
dti-1318	39	9	ma	ma	PROPN
dti-1318	39	10	)	)	PUNCT
dti-1318	39	11	,	,	PUNCT
dti-1318	39	12	capsid	capsid	PROPN
dti-1318	39	13	(	(	PUNCT
dti-1318	39	14	ca	ca	NOUN
dti-1318	39	15	)	)	PUNCT
dti-1318	39	16	,	,	PUNCT
dti-1318	39	17	nucleocapsid	nucleocapsid	NOUN
dti-1318	39	18	(	(	PUNCT
dti-1318	39	19	nc	nc	PROPN
dti-1318	39	20	)	)	PUNCT
dti-1318	39	21	,	,	PUNCT
dti-1318	39	22	p6	p6	PROPN
dti-1318	39	23	and	and	CCONJ
dti-1318	39	24	two	two	NUM
dti-1318	39	25	spacer	spacer	NOUN
dti-1318	39	26	peptides	peptide	NOUN
dti-1318	39	27	,	,	PUNCT
dti-1318	39	28	p1	p1	NOUN
dti-1318	39	29	and	and	CCONJ
dti-1318	39	30	p2	p2	NOUN
dti-1318	39	31	.	.	PUNCT
dti-1318	40	1	gag	gag	NOUN
dti-1318	40	2	-	-	PUNCT
dti-1318	40	3	pol	pol	NOUN
dti-1318	40	4	also	also	ADV
dti-1318	40	5	encodes	encode	VERB
dti-1318	40	6	ma	ma	PROPN
dti-1318	40	7	,	,	PUNCT
dti-1318	40	8	ca	ca	NOUN
dti-1318	40	9	and	and	CCONJ
dti-1318	40	10	nc	nc	VERB
dti-1318	40	11	in	in	ADP
dti-1318	40	12	addition	addition	NOUN
dti-1318	40	13	to	to	ADP
dti-1318	40	14	the	the	DET
dti-1318	40	15	three	three	NUM
dti-1318	40	16	viral	viral	ADJ
dti-1318	40	17	enzymes	enzyme	NOUN
dti-1318	40	18	,	,	PUNCT
dti-1318	40	19	pr	pr	NOUN
dti-1318	40	20	,	,	PUNCT
dti-1318	40	21	rt	rt	PROPN
dti-1318	40	22	and	and	CCONJ
dti-1318	40	23	in	in	ADP
dti-1318	40	24	.	.	PUNCT
dti-1318	41	1	after	after	SCONJ
dti-1318	41	2	translation	translation	NOUN
dti-1318	41	3	,	,	PUNCT
dti-1318	41	4	gag	gag	NOUN
dti-1318	41	5	and	and	CCONJ
dti-1318	41	6	gag	gag	NOUN
dti-1318	41	7	-	-	PUNCT
dti-1318	41	8	pol	pol	NOUN
dti-1318	41	9	are	be	AUX
dti-1318	41	10	targeted	target	VERB
dti-1318	41	11	to	to	ADP
dti-1318	41	12	the	the	DET
dti-1318	41	13	host	host	NOUN
dti-1318	41	14	cell	cell	NOUN
dti-1318	41	15	plasma	plasma	NOUN
dti-1318	41	16	membrane	membrane	NOUN
dti-1318	41	17	,	,	PUNCT
dti-1318	41	18	a	a	DET
dti-1318	41	19	process	process	NOUN
dti-1318	41	20	that	that	PRON
dti-1318	41	21	is	be	AUX
dti-1318	41	22	dependent	dependent	ADJ
dti-1318	41	23	on	on	ADP
dti-1318	41	24	the	the	DET
dti-1318	41	25	myristoylation	myristoylation	NOUN
dti-1318	41	26	of	of	ADP
dti-1318	41	27	the	the	DET
dti-1318	41	28	n	n	NOUN
dti-1318	41	29	-	-	PUNCT
dti-1318	41	30	terminus	terminus	NOUN
dti-1318	41	31	of	of	ADP
dti-1318	41	32	gag	gag	NOUN
dti-1318	41	33	(	(	PUNCT
dti-1318	41	34	fig	fig	NOUN
dti-1318	41	35	.	.	NOUN
dti-1318	42	1	1	1	NUM
dti-1318	42	2	)	)	PUNCT
dti-1318	42	3	(	(	PUNCT
dti-1318	42	4	swanstrom	swanstrom	NOUN
dti-1318	42	5	,	,	PUNCT
dti-1318	42	6	1997	1997	NUM
dti-1318	42	7	)	)	PUNCT
dti-1318	42	8	.	.	PUNCT
dti-1318	43	1	inhibition	inhibition	NOUN
dti-1318	43	2	of	of	ADP
dti-1318	43	3	myristoylation	myristoylation	NOUN
dti-1318	43	4	disrupts	disrupt	VERB
dti-1318	43	5	the	the	DET
dti-1318	43	6	proper	proper	ADJ
dti-1318	43	7	targeting	targeting	NOUN
dti-1318	43	8	of	of	ADP
dti-1318	43	9	gag	gag	NOUN
dti-1318	43	10	and	and	CCONJ
dti-1318	43	11	gag	gag	NOUN
dti-1318	43	12	-	-	PUNCT
dti-1318	43	13	pol	pol	NOUN
dti-1318	43	14	to	to	ADP
dti-1318	43	15	the	the	DET
dti-1318	43	16	plasma	plasma	NOUN
dti-1318	43	17	membrane	membrane	NOUN
dti-1318	43	18	(	(	PUNCT
dti-1318	43	19	swanstrom	swanstrom	NOUN
dti-1318	43	20	,	,	PUNCT
dti-1318	43	21	1997	1997	NUM
dti-1318	43	22	)	)	PUNCT
dti-1318	43	23	.	.	PUNCT
dti-1318	44	1	gag	gag	NOUN
dti-1318	44	2	-	-	PUNCT
dti-1318	44	3	gag	gag	NOUN
dti-1318	44	4	,	,	PUNCT
dti-1318	44	5	gag	gag	NOUN
dti-1318	44	6	/	/	SYM
dti-1318	44	7	gag	gag	NOUN
dti-1318	44	8	-	-	PUNCT
dti-1318	44	9	pol	pol	NOUN
dti-1318	44	10	and	and	CCONJ
dti-1318	44	11	gag	gag	NOUN
dti-1318	44	12	-	-	PUNCT
dti-1318	44	13	rna	rna	NOUN
dti-1318	44	14	interactions	interaction	NOUN
dti-1318	44	15	are	be	AUX
dti-1318	44	16	also	also	ADV
dti-1318	44	17	essential	essential	ADJ
dti-1318	44	18	for	for	ADP
dti-1318	44	19	the	the	DET
dti-1318	44	20	proper	proper	ADJ
dti-1318	44	21	assembly	assembly	NOUN
dti-1318	44	22	and	and	CCONJ
dti-1318	44	23	maturation	maturation	NOUN
dti-1318	44	24	of	of	ADP
dti-1318	44	25	infectious	infectious	ADJ
dti-1318	44	26	virions	virion	NOUN
dti-1318	44	27	.	.	PUNCT
dti-1318	45	1	gag	gag	NOUN
dti-1318	45	2	and	and	CCONJ
dti-1318	45	3	gag	gag	NOUN
dti-1318	45	4	-	-	PUNCT
dti-1318	45	5	pol	pol	NOUN
dti-1318	45	6	assemble	assemble	NOUN
dti-1318	45	7	at	at	ADP
dti-1318	45	8	the	the	DET
dti-1318	45	9	plasma	plasma	NOUN
dti-1318	45	10	membrane	membrane	NOUN
dti-1318	45	11	along	along	ADP
dti-1318	45	12	with	with	ADP
dti-1318	45	13	viral	viral	ADJ
dti-1318	45	14	envelope	envelope	NOUN
dti-1318	45	15	glycoproteins	glycoprotein	NOUN
dti-1318	45	16	gp120	gp120	PROPN
dti-1318	45	17	and	and	CCONJ
dti-1318	45	18	gp41	gp41	PROPN
dti-1318	45	19	to	to	PART
dti-1318	45	20	form	form	VERB
dti-1318	45	21	immature	immature	ADJ
dti-1318	45	22	viral	viral	ADJ
dti-1318	45	23	particles	particle	NOUN
dti-1318	45	24	(	(	PUNCT
dti-1318	45	25	fig	fig	NOUN
dti-1318	45	26	.	.	NOUN
dti-1318	46	1	1	1	NUM
dti-1318	46	2	)	)	PUNCT
dti-1318	46	3	.	.	PUNCT
dti-1318	47	1	gag	gag	NOUN
dti-1318	47	2	is	be	AUX
dti-1318	47	3	necessary	necessary	ADJ
dti-1318	47	4	and	and	CCONJ
dti-1318	47	5	suffi	suffi	NOUN
dti-1318	47	6	cient	cient	NOUN
dti-1318	47	7	for	for	ADP
dti-1318	47	8	virus	virus	NOUN
dti-1318	47	9	particle	particle	NOUN
dti-1318	47	10	formation	formation	NOUN
dti-1318	47	11	(	(	PUNCT
dti-1318	47	12	freed	free	VERB
dti-1318	47	13	,	,	PUNCT
dti-1318	47	14	1998	1998	NUM
dti-1318	47	15	;	;	PUNCT
dti-1318	47	16	swanstrom	swanstrom	NOUN
dti-1318	47	17	,	,	PUNCT
dti-1318	47	18	1997	1997	NUM
dti-1318	47	19	)	)	PUNCT
dti-1318	47	20	.	.	PUNCT
dti-1318	48	1	the	the	DET
dti-1318	48	2	viral	viral	ADJ
dti-1318	48	3	genomic	genomic	NOUN
dti-1318	48	4	rna	rna	NOUN
dti-1318	48	5	is	be	AUX
dti-1318	48	6	also	also	ADV
dti-1318	48	7	packaged	package	VERB
dti-1318	48	8	into	into	ADP
dti-1318	48	9	virions	virion	NOUN
dti-1318	48	10	through	through	ADP
dti-1318	48	11	interactions	interaction	NOUN
dti-1318	48	12	with	with	ADP
dti-1318	48	13	the	the	DET
dti-1318	48	14	nc	nc	PROPN
dti-1318	48	15	of	of	ADP
dti-1318	48	16	gag	gag	PROPN
dti-1318	48	17	and	and	CCONJ
dti-1318	48	18	a	a	DET
dti-1318	48	19	psi	psi	NOUN
dti-1318	48	20	packaging	packaging	NOUN
dti-1318	48	21	signal	signal	NOUN
dti-1318	48	22	in	in	ADP
dti-1318	48	23	the	the	DET
dti-1318	48	24	genome	genome	NOUN
dti-1318	48	25	(	(	PUNCT
dti-1318	48	26	swanstrom	swanstrom	NOUN
dti-1318	48	27	,	,	PUNCT
dti-1318	48	28	1997	1997	NUM
dti-1318	48	29	)	)	PUNCT
dti-1318	48	30	.	.	PUNCT
dti-1318	49	1	as	as	SCONJ
dti-1318	49	2	the	the	DET
dti-1318	49	3	newly	newly	ADV
dti-1318	49	4	assembled	assemble	VERB
dti-1318	49	5	virions	virion	NOUN
dti-1318	49	6	bud	bud	ADJ
dti-1318	49	7	from	from	ADP
dti-1318	49	8	the	the	DET
dti-1318	49	9	cell	cell	NOUN
dti-1318	49	10	it	it	PRON
dti-1318	49	11	is	be	AUX
dti-1318	49	12	believed	believe	VERB
dti-1318	49	13	that	that	SCONJ
dti-1318	49	14	gag	gag	NOUN
dti-1318	49	15	-	-	PUNCT
dti-1318	49	16	pol	pol	NOUN
dti-1318	49	17	polyproteins	polyprotein	NOUN
dti-1318	49	18	oligomerize	oligomerize	VERB
dti-1318	49	19	in	in	ADP
dti-1318	49	20	order	order	NOUN
dti-1318	49	21	to	to	PART
dti-1318	49	22	activate	activate	VERB
dti-1318	49	23	the	the	DET
dti-1318	49	24	hiv-1	hiv-1	ADJ
dti-1318	49	25	pr	pr	NOUN
dti-1318	49	26	by	by	ADP
dti-1318	49	27	forming	form	VERB
dti-1318	49	28	an	an	DET
dti-1318	49	29	active	active	ADJ
dti-1318	49	30	pr	pr	NOUN
dti-1318	49	31	homodimer	homodimer	NOUN
dti-1318	49	32	.	.	PUNCT
dti-1318	50	1	this	this	DET
dti-1318	50	2	results	result	VERB
dti-1318	50	3	in	in	ADP
dti-1318	50	4	the	the	DET
dti-1318	50	5	sequential	sequential	ADJ
dti-1318	50	6	cleavage	cleavage	NOUN
dti-1318	50	7	of	of	ADP
dti-1318	50	8	gag	gag	NOUN
dti-1318	50	9	and	and	CCONJ
dti-1318	50	10	gag	gag	NOUN
dti-1318	50	11	-	-	PUNCT
dti-1318	50	12	pol	pol	NOUN
dti-1318	50	13	into	into	ADP
dti-1318	50	14	the	the	DET
dti-1318	50	15	mature	mature	ADJ
dti-1318	50	16	structural	structural	ADJ
dti-1318	50	17	proteins	protein	NOUN
dti-1318	50	18	and	and	CCONJ
dti-1318	50	19	enzymes	enzyme	NOUN
dti-1318	50	20	(	(	PUNCT
dti-1318	50	21	kaplan	kaplan	PROPN
dti-1318	50	22	et	et	PROPN
dti-1318	50	23	al	al	PROPN
dti-1318	50	24	.	.	PROPN
dti-1318	50	25	1994	1994	NUM
dti-1318	50	26	;	;	PUNCT
dti-1318	50	27	pettit	pettit	PROPN
dti-1318	50	28	et	et	PROPN
dti-1318	50	29	al	al	PROPN
dti-1318	50	30	.	.	PROPN
dti-1318	50	31	1998	1998	NUM
dti-1318	50	32	)	)	PUNCT
dti-1318	50	33	.	.	PUNCT
dti-1318	51	1	agents	agent	NOUN
dti-1318	51	2	that	that	PRON
dti-1318	51	3	bind	bind	VERB
dti-1318	51	4	to	to	ADP
dti-1318	51	5	domains	domain	NOUN
dti-1318	51	6	in	in	ADP
dti-1318	51	7	gag	gag	NOUN
dti-1318	51	8	or	or	CCONJ
dti-1318	51	9	gag	gag	NOUN
dti-1318	51	10	-	-	PUNCT
dti-1318	51	11	pol	pol	NOUN
dti-1318	51	12	and	and	CCONJ
dti-1318	51	13	modulate	modulate	VERB
dti-1318	51	14	their	their	PRON
dti-1318	51	15	oligomerization	oligomerization	NOUN
dti-1318	51	16	are	be	AUX
dti-1318	51	17	likely	likely	ADJ
dti-1318	51	18	to	to	PART
dti-1318	51	19	have	have	VERB
dti-1318	51	20	a	a	DET
dti-1318	51	21	negative	negative	ADJ
dti-1318	51	22	effect	effect	NOUN
dti-1318	51	23	on	on	ADP
dti-1318	51	24	virus	virus	NOUN
dti-1318	51	25	assembly	assembly	NOUN
dti-1318	51	26	,	,	PUNCT
dti-1318	51	27	maturation	maturation	NOUN
dti-1318	51	28	and	and	CCONJ
dti-1318	51	29	budding	bud	VERB
dti-1318	51	30	(	(	PUNCT
dti-1318	51	31	fig	fig	NOUN
dti-1318	51	32	.	.	PUNCT
dti-1318	51	33	1	1	NUM
dti-1318	51	34	)	)	PUNCT
dti-1318	51	35	.	.	PUNCT
dti-1318	52	1	agents	agent	NOUN
dti-1318	52	2	that	that	PRON
dti-1318	52	3	interfere	interfere	VERB
dti-1318	52	4	with	with	ADP
dti-1318	52	5	hiv-1	hiv-1	X
dti-1318	52	6	pr	pr	NOUN
dti-1318	52	7	mediated	mediate	VERB
dti-1318	52	8	cleavage	cleavage	NOUN
dti-1318	52	9	of	of	ADP
dti-1318	52	10	gag	gag	NOUN
dti-1318	52	11	and	and	CCONJ
dti-1318	52	12	gag	gag	NOUN
dti-1318	52	13	-	-	PUNCT
dti-1318	52	14	pol	pol	NOUN
dti-1318	52	15	result	result	NOUN
dti-1318	52	16	in	in	ADP
dti-1318	52	17	the	the	DET
dti-1318	52	18	production	production	NOUN
dti-1318	52	19	of	of	ADP
dti-1318	52	20	immature	immature	ADJ
dti-1318	52	21	viral	viral	ADJ
dti-1318	52	22	particles	particle	NOUN
dti-1318	52	23	that	that	PRON
dti-1318	52	24	are	be	AUX
dti-1318	52	25	non	non	ADJ
dti-1318	52	26	-	-	ADJ
dti-1318	52	27	infectious	infectious	ADJ
dti-1318	52	28	(	(	PUNCT
dti-1318	52	29	kohl	kohl	NOUN
dti-1318	52	30	et	et	PROPN
dti-1318	52	31	al	al	PROPN
dti-1318	52	32	.	.	PROPN
dti-1318	52	33	1988	1988	NUM
dti-1318	52	34	)	)	PUNCT
dti-1318	52	35	.	.	PUNCT
dti-1318	53	1	virus	virus	NOUN
dti-1318	53	2	particle	particle	NOUN
dti-1318	53	3	budding	budding	NOUN
dti-1318	53	4	and	and	CCONJ
dti-1318	53	5	egress	egress	NOUN
dti-1318	53	6	is	be	AUX
dti-1318	53	7	mediated	mediate	VERB
dti-1318	53	8	by	by	ADP
dti-1318	53	9	interactions	interaction	NOUN
dti-1318	53	10	of	of	ADP
dti-1318	53	11	viral	viral	ADJ
dti-1318	53	12	proteins	protein	NOUN
dti-1318	53	13	such	such	ADJ
dti-1318	53	14	as	as	ADP
dti-1318	53	15	the	the	DET
dti-1318	53	16	p6	p6	ADJ
dti-1318	53	17	late	late	ADJ
dti-1318	53	18	domain	domain	NOUN
dti-1318	53	19	with	with	ADP
dti-1318	53	20	components	component	NOUN
dti-1318	53	21	of	of	ADP
dti-1318	53	22	the	the	DET
dti-1318	53	23	endosomal	endosomal	ADJ
dti-1318	53	24	sorting	sort	VERB
dti-1318	53	25	machinery	machinery	NOUN
dti-1318	53	26	.	.	PUNCT
dti-1318	54	1	ion	ion	NOUN
dti-1318	54	2	channels	channel	NOUN
dti-1318	54	3	formed	form	VERB
dti-1318	54	4	by	by	ADP
dti-1318	54	5	viral	viral	ADJ
dti-1318	54	6	protein	protein	NOUN
dti-1318	54	7	u	u	NOUN
dti-1318	54	8	(	(	PUNCT
dti-1318	54	9	vpu	vpu	NOUN
dti-1318	54	10	)	)	PUNCT
dti-1318	54	11	also	also	ADV
dti-1318	54	12	facilitate	facilitate	VERB
dti-1318	54	13	viral	viral	ADJ
dti-1318	54	14	particle	particle	NOUN
dti-1318	54	15	egress	egress	NOUN
dti-1318	54	16	from	from	ADP
dti-1318	54	17	the	the	DET
dti-1318	54	18	host	host	NOUN
dti-1318	54	19	cell	cell	NOUN
dti-1318	54	20	.	.	PUNCT
dti-1318	55	1	below	below	SCONJ
dti-1318	55	2	we	we	PRON
dti-1318	55	3	describe	describe	VERB
dti-1318	55	4	in	in	ADP
dti-1318	55	5	more	more	ADJ
dti-1318	55	6	detail	detail	NOUN
dti-1318	55	7	the	the	DET
dti-1318	55	8	161	161	NUM
dti-1318	55	9	targeting	target	VERB
dti-1318	55	10	the	the	DET
dti-1318	55	11	late	late	ADJ
dti-1318	55	12	stages	stage	NOUN
dti-1318	55	13	of	of	ADP
dti-1318	55	14	hiv-1	hiv-1	X
dti-1318	55	15	replication	replication	NOUN
dti-1318	55	16	drug	drug	NOUN
dti-1318	55	17	target	target	NOUN
dti-1318	55	18	insights	insight	NOUN
dti-1318	55	19	2007	2007	NUM
dti-1318	55	20	:	:	PUNCT
dti-1318	55	21	2	2	NUM
dti-1318	55	22	specifi	specifi	X
dti-1318	55	23	c	c	NOUN
dti-1318	55	24	processes	process	NOUN
dti-1318	55	25	required	require	VERB
dti-1318	55	26	for	for	ADP
dti-1318	55	27	viral	viral	ADJ
dti-1318	55	28	assembly	assembly	NOUN
dti-1318	55	29	,	,	PUNCT
dti-1318	55	30	maturation	maturation	NOUN
dti-1318	55	31	and	and	CCONJ
dti-1318	55	32	budding	bud	VERB
dti-1318	55	33	and	and	CCONJ
dti-1318	55	34	agents	agent	NOUN
dti-1318	55	35	that	that	PRON
dti-1318	55	36	have	have	AUX
dti-1318	55	37	been	be	AUX
dti-1318	55	38	described	describe	VERB
dti-1318	55	39	that	that	SCONJ
dti-1318	55	40	block	block	VERB
dti-1318	55	41	these	these	DET
dti-1318	55	42	steps	step	NOUN
dti-1318	55	43	.	.	PUNCT
dti-1318	56	1	inhibitors	inhibitor	NOUN
dti-1318	56	2	of	of	ADP
dti-1318	56	3	gag	gag	NOUN
dti-1318	56	4	and	and	CCONJ
dti-1318	56	5	gag	gag	NOUN
dti-1318	56	6	-	-	PUNCT
dti-1318	56	7	pol	pol	NOUN
dti-1318	56	8	expression	expression	NOUN
dti-1318	56	9	:	:	PUNCT
dti-1318	56	10	targeting	target	VERB
dti-1318	56	11	ribosomal	ribosomal	ADJ
dti-1318	56	12	frameshifting	frameshifting	NOUN
dti-1318	56	13	hiv-1	hiv-1	X
dti-1318	56	14	gag	gag	NOUN
dti-1318	56	15	and	and	CCONJ
dti-1318	56	16	gag	gag	NOUN
dti-1318	56	17	-	-	PUNCT
dti-1318	56	18	pol	pol	NOUN
dti-1318	56	19	polyproteins	polyprotein	NOUN
dti-1318	56	20	are	be	AUX
dti-1318	56	21	encoded	encode	VERB
dti-1318	56	22	by	by	ADP
dti-1318	56	23	overlapping	overlap	VERB
dti-1318	56	24	open	open	ADJ
dti-1318	56	25	reading	reading	NOUN
dti-1318	56	26	frames	frame	NOUN
dti-1318	56	27	on	on	ADP
dti-1318	56	28	the	the	DET
dti-1318	56	29	same	same	ADJ
dti-1318	56	30	unspliced	unspliced	ADJ
dti-1318	56	31	mrna	mrna	PROPN
dti-1318	56	32	.	.	PUNCT
dti-1318	57	1	during	during	ADP
dti-1318	57	2	translation	translation	NOUN
dti-1318	57	3	gag	gag	NOUN
dti-1318	57	4	-	-	PUNCT
dti-1318	57	5	pol	pol	NOUN
dti-1318	57	6	is	be	AUX
dti-1318	57	7	synthesized	synthesize	VERB
dti-1318	57	8	by	by	ADP
dti-1318	57	9	a	a	DET
dti-1318	57	10	-1	-1	ADV
dti-1318	57	11	ribosomal	ribosomal	ADJ
dti-1318	57	12	frameshifting	frameshifte	VERB
dti-1318	57	13	mechanism	mechanism	NOUN
dti-1318	57	14	that	that	PRON
dti-1318	57	15	occurs	occur	VERB
dti-1318	57	16	at	at	ADP
dti-1318	57	17	a	a	DET
dti-1318	57	18	frequency	frequency	NOUN
dti-1318	57	19	of	of	ADP
dti-1318	57	20	5	5	NUM
dti-1318	57	21	to	to	PART
dti-1318	57	22	10	10	NUM
dti-1318	57	23	%	%	NOUN
dti-1318	57	24	of	of	ADP
dti-1318	57	25	gag	gag	NOUN
dti-1318	57	26	translation	translation	NOUN
dti-1318	57	27	events	event	NOUN
dti-1318	57	28	(	(	PUNCT
dti-1318	57	29	jacks	jack	NOUN
dti-1318	57	30	et	et	PROPN
dti-1318	57	31	al	al	PROPN
dti-1318	57	32	.	.	PROPN
dti-1318	57	33	1988b	1988b	NUM
dti-1318	57	34	)	)	PUNCT
dti-1318	57	35	.	.	PUNCT
dti-1318	58	1	similar	similar	ADJ
dti-1318	58	2	frameshifting	frameshifte	VERB
dti-1318	58	3	mechanisms	mechanism	NOUN
dti-1318	58	4	are	be	AUX
dti-1318	58	5	also	also	ADV
dti-1318	58	6	used	use	VERB
dti-1318	58	7	by	by	ADP
dti-1318	58	8	other	other	ADJ
dti-1318	58	9	retroviruses	retrovirus	NOUN
dti-1318	58	10	including	include	VERB
dti-1318	58	11	rous	rous	ADJ
dti-1318	58	12	sarcoma	sarcoma	NOUN
dti-1318	58	13	virus	virus	NOUN
dti-1318	58	14	and	and	CCONJ
dti-1318	58	15	mouse	mouse	PROPN
dti-1318	58	16	mammary	mammary	ADJ
dti-1318	58	17	tumor	tumor	NOUN
dti-1318	58	18	virus	virus	NOUN
dti-1318	58	19	in	in	ADP
dti-1318	58	20	order	order	NOUN
dti-1318	58	21	to	to	PART
dti-1318	58	22	regulate	regulate	VERB
dti-1318	58	23	expression	expression	NOUN
dti-1318	58	24	of	of	ADP
dti-1318	58	25	gag	gag	NOUN
dti-1318	58	26	-	-	PUNCT
dti-1318	58	27	pol	pol	NOUN
dti-1318	58	28	(	(	PUNCT
dti-1318	58	29	jacks	jack	NOUN
dti-1318	58	30	and	and	CCONJ
dti-1318	58	31	varmus	varmus	NOUN
dti-1318	58	32	,	,	PUNCT
dti-1318	58	33	1985	1985	NUM
dti-1318	58	34	;	;	PUNCT
dti-1318	58	35	jacks	jack	NOUN
dti-1318	58	36	et	et	PROPN
dti-1318	58	37	al	al	PROPN
dti-1318	58	38	.	.	PROPN
dti-1318	58	39	1987	1987	NUM
dti-1318	58	40	;	;	PUNCT
dti-1318	58	41	jacks	jack	NOUN
dti-1318	58	42	et	et	PROPN
dti-1318	58	43	al	al	PROPN
dti-1318	58	44	.	.	PROPN
dti-1318	58	45	1988a	1988a	NUM
dti-1318	58	46	)	)	PUNCT
dti-1318	58	47	.	.	PUNCT
dti-1318	59	1	the	the	DET
dti-1318	59	2	hiv-1	hiv-1	X
dti-1318	59	3	frameshift	frameshift	NOUN
dti-1318	59	4	site	site	NOUN
dti-1318	59	5	is	be	AUX
dti-1318	59	6	a	a	DET
dti-1318	59	7	heptanucleotide	heptanucleotide	ADJ
dti-1318	59	8	au	au	ADJ
dti-1318	59	9	-	-	ADJ
dti-1318	59	10	rich	rich	ADJ
dti-1318	59	11	sequence	sequence	NOUN
dti-1318	59	12	(	(	PUNCT
dti-1318	59	13	uuuuuua	uuuuuua	NOUN
dti-1318	59	14	)	)	PUNCT
dti-1318	59	15	found	find	VERB
dti-1318	59	16	at	at	ADP
dti-1318	59	17	the	the	DET
dti-1318	59	18	3′	3′	NUM
dti-1318	59	19	end	end	NOUN
dti-1318	59	20	of	of	ADP
dti-1318	59	21	the	the	DET
dti-1318	59	22	nc	nc	PROPN
dti-1318	59	23	coding	code	VERB
dti-1318	59	24	sequence	sequence	NOUN
dti-1318	59	25	and	and	CCONJ
dti-1318	59	26	is	be	AUX
dti-1318	59	27	conserved	conserve	VERB
dti-1318	59	28	amongst	amongst	ADP
dti-1318	59	29	hiv-1	hiv-1	X
dti-1318	59	30	isolates	isolate	NOUN
dti-1318	59	31	.	.	PUNCT
dti-1318	60	1	this	this	DET
dti-1318	60	2	slippery	slippery	ADJ
dti-1318	60	3	sequence	sequence	NOUN
dti-1318	60	4	and	and	CCONJ
dti-1318	60	5	a	a	DET
dti-1318	60	6	downstream	downstream	ADJ
dti-1318	60	7	rna	rna	NOUN
dti-1318	60	8	stem	stem	NOUN
dti-1318	60	9	loop	loop	NOUN
dti-1318	60	10	structure	structure	NOUN
dti-1318	60	11	stall	stall	VERB
dti-1318	60	12	the	the	DET
dti-1318	60	13	ribosome	ribosome	NOUN
dti-1318	60	14	during	during	ADP
dti-1318	60	15	the	the	DET
dti-1318	60	16	synthesis	synthesis	NOUN
dti-1318	60	17	of	of	ADP
dti-1318	60	18	gag	gag	NOUN
dti-1318	60	19	,	,	PUNCT
dti-1318	60	20	allowing	allow	VERB
dti-1318	60	21	the	the	DET
dti-1318	60	22	ribosome	ribosome	NOUN
dti-1318	60	23	to	to	PART
dti-1318	60	24	slip	slip	VERB
dti-1318	60	25	figure	figure	NOUN
dti-1318	60	26	1	1	NUM
dti-1318	60	27	.	.	PUNCT
dti-1318	60	28	overview	overview	NOUN
dti-1318	60	29	of	of	ADP
dti-1318	60	30	the	the	DET
dti-1318	60	31	hiv-1	hiv-1	ADJ
dti-1318	60	32	life	life	NOUN
dti-1318	60	33	-	-	PUNCT
dti-1318	60	34	cycle	cycle	NOUN
dti-1318	60	35	.	.	PUNCT
dti-1318	61	1	early	early	ADJ
dti-1318	61	2	events	event	NOUN
dti-1318	61	3	in	in	ADP
dti-1318	61	4	virus	virus	NOUN
dti-1318	61	5	replication	replication	NOUN
dti-1318	61	6	include	include	VERB
dti-1318	61	7	attachment	attachment	NOUN
dti-1318	61	8	,	,	PUNCT
dti-1318	61	9	fusion	fusion	NOUN
dti-1318	61	10	and	and	CCONJ
dti-1318	61	11	uncoating	uncoating	NOUN
dti-1318	61	12	of	of	ADP
dti-1318	61	13	the	the	DET
dti-1318	61	14	virus	virus	NOUN
dti-1318	61	15	followed	follow	VERB
dti-1318	61	16	by	by	ADP
dti-1318	61	17	reverse	reverse	ADJ
dti-1318	61	18	transcription	transcription	NOUN
dti-1318	61	19	in	in	ADP
dti-1318	61	20	the	the	DET
dti-1318	61	21	cytoplasm	cytoplasm	NOUN
dti-1318	61	22	of	of	ADP
dti-1318	61	23	the	the	DET
dti-1318	61	24	cell	cell	NOUN
dti-1318	61	25	,	,	PUNCT
dti-1318	61	26	nuclear	nuclear	ADJ
dti-1318	61	27	import	import	NOUN
dti-1318	61	28	of	of	ADP
dti-1318	61	29	the	the	DET
dti-1318	61	30	preintegration	preintegration	NOUN
dti-1318	61	31	complex	complex	NOUN
dti-1318	61	32	and	and	CCONJ
dti-1318	61	33	integration	integration	NOUN
dti-1318	61	34	of	of	ADP
dti-1318	61	35	the	the	DET
dti-1318	61	36	proviral	proviral	ADJ
dti-1318	61	37	dna	dna	PROPN
dti-1318	61	38	precursor	precursor	NOUN
dti-1318	61	39	into	into	ADP
dti-1318	61	40	the	the	DET
dti-1318	61	41	host	host	NOUN
dti-1318	61	42	cell	cell	NOUN
dti-1318	61	43	chromosome	chromosome	NOUN
dti-1318	61	44	.	.	PUNCT
dti-1318	62	1	late	late	ADJ
dti-1318	62	2	events	event	NOUN
dti-1318	62	3	begin	begin	VERB
dti-1318	62	4	with	with	ADP
dti-1318	62	5	transcription	transcription	NOUN
dti-1318	62	6	of	of	ADP
dti-1318	62	7	unspliced	unspliced	ADJ
dti-1318	62	8	and	and	CCONJ
dti-1318	62	9	spliced	spliced	ADJ
dti-1318	62	10	rna	rna	NOUN
dti-1318	62	11	from	from	ADP
dti-1318	62	12	the	the	DET
dti-1318	62	13	provirus	provirus	NOUN
dti-1318	62	14	and	and	CCONJ
dti-1318	62	15	export	export	NOUN
dti-1318	62	16	of	of	ADP
dti-1318	62	17	the	the	DET
dti-1318	62	18	mrnas	mrna	NOUN
dti-1318	62	19	to	to	ADP
dti-1318	62	20	the	the	DET
dti-1318	62	21	cytoplasm	cytoplasm	NOUN
dti-1318	62	22	,	,	PUNCT
dti-1318	62	23	resulting	result	VERB
dti-1318	62	24	in	in	ADP
dti-1318	62	25	the	the	DET
dti-1318	62	26	translation	translation	NOUN
dti-1318	62	27	of	of	ADP
dti-1318	62	28	gag	gag	NOUN
dti-1318	62	29	,	,	PUNCT
dti-1318	62	30	gag	gag	NOUN
dti-1318	62	31	-	-	PUNCT
dti-1318	62	32	pol	pol	NOUN
dti-1318	62	33	,	,	PUNCT
dti-1318	62	34	env	env	NOUN
dti-1318	62	35	and	and	CCONJ
dti-1318	62	36	the	the	DET
dti-1318	62	37	accessory	accessory	NOUN
dti-1318	62	38	and	and	CCONJ
dti-1318	62	39	regulatory	regulatory	ADJ
dti-1318	62	40	proteins	protein	NOUN
dti-1318	62	41	of	of	ADP
dti-1318	62	42	hiv-1	hiv-1	X
dti-1318	62	43	.	.	PUNCT
dti-1318	63	1	regulation	regulation	NOUN
dti-1318	63	2	of	of	ADP
dti-1318	63	3	gag	gag	NOUN
dti-1318	63	4	-	-	PUNCT
dti-1318	63	5	pol	pol	NOUN
dti-1318	63	6	synthesis	synthesis	NOUN
dti-1318	63	7	is	be	AUX
dti-1318	63	8	mediated	mediate	VERB
dti-1318	63	9	by	by	ADP
dti-1318	63	10	a	a	DET
dti-1318	63	11	ribosomal	ribosomal	ADJ
dti-1318	63	12	frameshifting	frameshifte	VERB
dti-1318	63	13	mechanism	mechanism	NOUN
dti-1318	63	14	from	from	ADP
dti-1318	63	15	unspliced	unspliced	ADJ
dti-1318	63	16	mrna	mrna	PROPN
dti-1318	63	17	that	that	PRON
dti-1318	63	18	also	also	ADV
dti-1318	63	19	expresses	express	VERB
dti-1318	63	20	gag	gag	NOUN
dti-1318	63	21	.	.	PUNCT
dti-1318	64	1	myristoylation	myristoylation	NOUN
dti-1318	64	2	of	of	ADP
dti-1318	64	3	gag	gag	NOUN
dti-1318	64	4	is	be	AUX
dti-1318	64	5	necessary	necessary	ADJ
dti-1318	64	6	for	for	ADP
dti-1318	64	7	traffi	traffi	PROPN
dti-1318	64	8	cking	cke	VERB
dti-1318	64	9	of	of	ADP
dti-1318	64	10	gag	gag	NOUN
dti-1318	64	11	and	and	CCONJ
dti-1318	64	12	gag	gag	NOUN
dti-1318	64	13	-	-	PUNCT
dti-1318	64	14	pol	pol	NOUN
dti-1318	64	15	to	to	ADP
dti-1318	64	16	the	the	DET
dti-1318	64	17	site	site	NOUN
dti-1318	64	18	of	of	ADP
dti-1318	64	19	viral	viral	ADJ
dti-1318	64	20	assembly	assembly	NOUN
dti-1318	64	21	.	.	PUNCT
dti-1318	65	1	assembly	assembly	NOUN
dti-1318	65	2	is	be	AUX
dti-1318	65	3	driven	drive	VERB
dti-1318	65	4	by	by	ADP
dti-1318	65	5	interactions	interaction	NOUN
dti-1318	65	6	between	between	ADP
dti-1318	65	7	gag	gag	NOUN
dti-1318	65	8	-	-	PUNCT
dti-1318	65	9	gag	gag	NOUN
dti-1318	65	10	,	,	PUNCT
dti-1318	65	11	gag	gag	NOUN
dti-1318	65	12	/	/	SYM
dti-1318	65	13	gag	gag	NOUN
dti-1318	65	14	-	-	PUNCT
dti-1318	65	15	pol	pol	NOUN
dti-1318	65	16	,	,	PUNCT
dti-1318	65	17	gag	gag	NOUN
dti-1318	65	18	-	-	PUNCT
dti-1318	65	19	rna	rna	NOUN
dti-1318	65	20	.	.	PUNCT
dti-1318	66	1	viral	viral	ADJ
dti-1318	66	2	budding	budding	NOUN
dti-1318	66	3	and	and	CCONJ
dti-1318	66	4	egress	egress	NOUN
dti-1318	66	5	involves	involve	VERB
dti-1318	66	6	host	host	NOUN
dti-1318	66	7	cell	cell	NOUN
dti-1318	66	8	factors	factor	NOUN
dti-1318	66	9	.	.	PUNCT
dti-1318	67	1	during	during	ADP
dti-1318	67	2	or	or	CCONJ
dti-1318	67	3	shortly	shortly	ADV
dti-1318	67	4	after	after	ADP
dti-1318	67	5	budding	bud	VERB
dti-1318	67	6	the	the	DET
dti-1318	67	7	hiv-1	hiv-1	ADJ
dti-1318	67	8	pr	pr	NOUN
dti-1318	67	9	cleaves	cleave	VERB
dti-1318	67	10	the	the	DET
dti-1318	67	11	gag	gag	NOUN
dti-1318	67	12	and	and	CCONJ
dti-1318	67	13	gag	gag	NOUN
dti-1318	67	14	-	-	PUNCT
dti-1318	67	15	pol	pol	NOUN
dti-1318	67	16	polyproteins	polyprotein	NOUN
dti-1318	67	17	resulting	result	VERB
dti-1318	67	18	in	in	ADP
dti-1318	67	19	a	a	DET
dti-1318	67	20	mature	mature	ADJ
dti-1318	67	21	and	and	CCONJ
dti-1318	67	22	infectious	infectious	ADJ
dti-1318	67	23	viral	viral	ADJ
dti-1318	67	24	particle	particle	NOUN
dti-1318	67	25	.	.	PUNCT
dti-1318	68	1	late	late	ADJ
dti-1318	68	2	event	event	NOUN
dti-1318	68	3	targets	target	VERB
dti-1318	68	4	frameshifting	frameshifte	VERB
dti-1318	68	5	myristoylation	myristoylation	NOUN
dti-1318	68	6	&	&	CCONJ
dti-1318	68	7	trafficking	traffic	VERB
dti-1318	68	8	assembly	assembly	NOUN
dti-1318	68	9	budding	budding	PROPN
dti-1318	68	10	&	&	CCONJ
dti-1318	68	11	egress	egress	PROPN
dti-1318	68	12	maturation	maturation	NOUN
dti-1318	68	13	early	early	ADJ
dti-1318	68	14	events	event	NOUN
dti-1318	68	15	late	late	ADJ
dti-1318	68	16	events	event	NOUN
dti-1318	68	17	recognition	recognition	NOUN
dti-1318	68	18	&	&	CCONJ
dti-1318	68	19	attachment	attachment	NOUN
dti-1318	68	20	fusion	fusion	NOUN
dti-1318	68	21	uncoating	uncoating	NOUN
dti-1318	68	22	&	&	CCONJ
dti-1318	68	23	reverse	reverse	ADJ
dti-1318	68	24	transcription	transcription	NOUN
dti-1318	68	25	nuclear	nuclear	ADJ
dti-1318	68	26	import	import	PROPN
dti-1318	68	27	mrna	mrna	PROPN
dti-1318	68	28	export	export	PROPN
dti-1318	68	29	translation	translation	PROPN
dti-1318	68	30	myristoylation	myristoylation	PROPN
dti-1318	68	31	&	&	CCONJ
dti-1318	68	32	trafficking	traffic	VERB
dti-1318	68	33	maturation	maturation	NOUN
dti-1318	68	34	integration	integration	NOUN
dti-1318	68	35	transcription	transcription	NOUN
dti-1318	68	36	&	&	CCONJ
dti-1318	68	37	splicing	splicing	NOUN
dti-1318	68	38	assembly	assembly	NOUN
dti-1318	68	39	budding	budding	PROPN
dti-1318	68	40	&	&	CCONJ
dti-1318	68	41	egress	egress	PROPN
dti-1318	68	42	rtcpic	rtcpic	NOUN
dti-1318	68	43	gag	gag	NOUN
dti-1318	68	44	/	/	SYM
dti-1318	68	45	gag	gag	NOUN
dti-1318	68	46	-	-	PUNCT
dti-1318	68	47	pol	pol	NOUN
dti-1318	68	48	ratio	ratio	NOUN
dti-1318	68	49	myristoylation	myristoylation	PROPN
dti-1318	68	50	gag	gag	NOUN
dti-1318	68	51	/	/	SYM
dti-1318	68	52	gag	gag	NOUN
dti-1318	68	53	interactions	interaction	NOUN
dti-1318	68	54	gag	gag	NOUN
dti-1318	68	55	/	/	SYM
dti-1318	68	56	gag	gag	NOUN
dti-1318	68	57	-	-	PUNCT
dti-1318	68	58	pol	pol	NOUN
dti-1318	68	59	interactions	interaction	NOUN
dti-1318	68	60	gag	gag	NOUN
dti-1318	68	61	/	/	SYM
dti-1318	68	62	rna	rna	NOUN
dti-1318	68	63	interactions	interaction	NOUN
dti-1318	68	64	vpu	vpu	ADP
dti-1318	68	65	p6	p6	VERB
dti-1318	68	66	ptat	ptat	NOUN
dti-1318	68	67	motif	motif	NOUN
dti-1318	68	68	pr	pr	NOUN
dti-1318	68	69	dimerization	dimerization	NOUN
dti-1318	68	70	rt	rt	NOUN
dti-1318	68	71	dimerization	dimerization	NOUN
dti-1318	68	72	in	in	ADP
dti-1318	68	73	dimerization	dimerization	NOUN
dti-1318	68	74	gag	gag	NOUN
dti-1318	68	75	cleavage	cleavage	NOUN
dti-1318	68	76	162	162	NUM
dti-1318	68	77	wapling	waple	VERB
dti-1318	68	78	et	et	PROPN
dti-1318	68	79	al	al	PROPN
dti-1318	68	80	drug	drug	PROPN
dti-1318	68	81	target	target	NOUN
dti-1318	68	82	insights	insight	NOUN
dti-1318	68	83	2007	2007	NUM
dti-1318	68	84	:	:	PUNCT
dti-1318	68	85	2	2	NUM
dti-1318	68	86	back	back	ADV
dti-1318	68	87	one	one	NUM
dti-1318	68	88	nucleotide	nucleotide	NOUN
dti-1318	68	89	and	and	CCONJ
dti-1318	68	90	enable	enable	VERB
dti-1318	68	91	synthesis	synthesis	NOUN
dti-1318	68	92	of	of	ADP
dti-1318	68	93	the	the	DET
dti-1318	68	94	gag	gag	NOUN
dti-1318	68	95	-	-	PUNCT
dti-1318	68	96	pol	pol	NOUN
dti-1318	68	97	fusion	fusion	NOUN
dti-1318	68	98	protein	protein	NOUN
dti-1318	68	99	(	(	PUNCT
dti-1318	68	100	jacks	jack	NOUN
dti-1318	68	101	et	et	PROPN
dti-1318	68	102	al	al	PROPN
dti-1318	68	103	.	.	PROPN
dti-1318	68	104	1988b	1988b	NUM
dti-1318	68	105	)	)	PUNCT
dti-1318	68	106	.	.	PUNCT
dti-1318	69	1	this	this	DET
dti-1318	69	2	sequence	sequence	NOUN
dti-1318	69	3	,	,	PUNCT
dti-1318	69	4	the	the	DET
dti-1318	69	5	stem	stem	NOUN
dti-1318	69	6	-	-	PUNCT
dti-1318	69	7	loop	loop	NOUN
dti-1318	69	8	structure	structure	NOUN
dti-1318	69	9	and	and	CCONJ
dti-1318	69	10	its	its	PRON
dti-1318	69	11	stability	stability	NOUN
dti-1318	69	12	and	and	CCONJ
dti-1318	69	13	adjacent	adjacent	ADJ
dti-1318	69	14	interacting	interact	VERB
dti-1318	69	15	sequences	sequence	NOUN
dti-1318	69	16	are	be	AUX
dti-1318	69	17	believed	believe	VERB
dti-1318	69	18	to	to	PART
dti-1318	69	19	be	be	AUX
dti-1318	69	20	the	the	DET
dti-1318	69	21	key	key	ADJ
dti-1318	69	22	components	component	NOUN
dti-1318	69	23	of	of	ADP
dti-1318	69	24	the	the	DET
dti-1318	69	25	frameshifting	frameshifte	VERB
dti-1318	69	26	signal	signal	NOUN
dti-1318	69	27	(	(	PUNCT
dti-1318	69	28	jacks	jack	NOUN
dti-1318	69	29	et	et	PROPN
dti-1318	69	30	al	al	PROPN
dti-1318	69	31	.	.	PROPN
dti-1318	69	32	1988b	1988b	NUM
dti-1318	69	33	;	;	PUNCT
dti-1318	69	34	kollmus	kollmus	PROPN
dti-1318	69	35	et	et	PROPN
dti-1318	69	36	al	al	PROPN
dti-1318	69	37	.	.	PROPN
dti-1318	69	38	1994	1994	NUM
dti-1318	69	39	;	;	PUNCT
dti-1318	69	40	hill	hill	PROPN
dti-1318	69	41	et	et	PROPN
dti-1318	69	42	al	al	PROPN
dti-1318	69	43	.	.	PROPN
dti-1318	69	44	2005	2005	NUM
dti-1318	69	45	)	)	PUNCT
dti-1318	69	46	.	.	PUNCT
dti-1318	70	1	details	detail	NOUN
dti-1318	70	2	of	of	ADP
dti-1318	70	3	a	a	DET
dti-1318	70	4	recently	recently	ADV
dti-1318	70	5	reported	report	VERB
dti-1318	70	6	nmr	nmr	NOUN
dti-1318	70	7	structure	structure	NOUN
dti-1318	70	8	and	and	CCONJ
dti-1318	70	9	an	an	DET
dti-1318	70	10	analysis	analysis	NOUN
dti-1318	70	11	of	of	ADP
dti-1318	70	12	current	current	ADJ
dti-1318	70	13	hiv-1	hiv-1	X
dti-1318	70	14	frameshifting	frameshifte	VERB
dti-1318	70	15	models	model	NOUN
dti-1318	70	16	have	have	AUX
dti-1318	70	17	recently	recently	ADV
dti-1318	70	18	been	be	AUX
dti-1318	70	19	reviewed	review	VERB
dti-1318	70	20	(	(	PUNCT
dti-1318	70	21	brierley	brierley	NOUN
dti-1318	70	22	and	and	CCONJ
dti-1318	70	23	dos	dos	PROPN
dti-1318	70	24	ramos	ramos	PROPN
dti-1318	70	25	,	,	PUNCT
dti-1318	70	26	2006	2006	NUM
dti-1318	70	27	)	)	PUNCT
dti-1318	70	28	.	.	PUNCT
dti-1318	71	1	studies	study	NOUN
dti-1318	71	2	demonstrate	demonstrate	VERB
dti-1318	71	3	that	that	SCONJ
dti-1318	71	4	perturbation	perturbation	NOUN
dti-1318	71	5	of	of	ADP
dti-1318	71	6	the	the	DET
dti-1318	71	7	gag	gag	NOUN
dti-1318	71	8	/	/	SYM
dti-1318	71	9	gag	gag	NOUN
dti-1318	71	10	-	-	PUNCT
dti-1318	71	11	pol	pol	NOUN
dti-1318	71	12	ratio	ratio	NOUN
dti-1318	71	13	result	result	NOUN
dti-1318	71	14	in	in	ADP
dti-1318	71	15	major	major	ADJ
dti-1318	71	16	defects	defect	NOUN
dti-1318	71	17	in	in	ADP
dti-1318	71	18	virus	virus	NOUN
dti-1318	71	19	replication	replication	NOUN
dti-1318	71	20	,	,	PUNCT
dti-1318	71	21	suggesting	suggest	VERB
dti-1318	71	22	that	that	SCONJ
dti-1318	71	23	interfering	interfere	VERB
dti-1318	71	24	with	with	ADP
dti-1318	71	25	ribosomal	ribosomal	NOUN
dti-1318	71	26	frameshifting	frameshifting	NOUN
dti-1318	71	27	represents	represent	VERB
dti-1318	71	28	a	a	DET
dti-1318	71	29	viable	viable	ADJ
dti-1318	71	30	drug	drug	NOUN
dti-1318	71	31	target	target	NOUN
dti-1318	71	32	.	.	PUNCT
dti-1318	72	1	alteration	alteration	NOUN
dti-1318	72	2	of	of	ADP
dti-1318	72	3	the	the	DET
dti-1318	72	4	gag	gag	NOUN
dti-1318	72	5	/	/	SYM
dti-1318	72	6	gag	gag	NOUN
dti-1318	72	7	-	-	PUNCT
dti-1318	72	8	pol	pol	NOUN
dti-1318	72	9	ratio	ratio	NOUN
dti-1318	72	10	,	,	PUNCT
dti-1318	72	11	by	by	ADP
dti-1318	72	12	engineering	engineer	VERB
dti-1318	72	13	vectors	vector	NOUN
dti-1318	72	14	with	with	ADP
dti-1318	72	15	gag	gag	NOUN
dti-1318	72	16	and	and	CCONJ
dti-1318	72	17	pol	pol	NOUN
dti-1318	72	18	genes	gene	NOUN
dti-1318	72	19	in	in	ADP
dti-1318	72	20	the	the	DET
dti-1318	72	21	same	same	ADJ
dti-1318	72	22	open	open	ADJ
dti-1318	72	23	reading	reading	NOUN
dti-1318	72	24	frame	frame	NOUN
dti-1318	72	25	,	,	PUNCT
dti-1318	72	26	results	result	NOUN
dti-1318	72	27	in	in	ADP
dti-1318	72	28	major	major	ADJ
dti-1318	72	29	defects	defect	NOUN
dti-1318	72	30	in	in	ADP
dti-1318	72	31	assembly	assembly	NOUN
dti-1318	72	32	and	and	CCONJ
dti-1318	72	33	budding	bud	VERB
dti-1318	72	34	(	(	PUNCT
dti-1318	72	35	karacostas	karacosta	NOUN
dti-1318	72	36	et	et	PROPN
dti-1318	72	37	al	al	PROPN
dti-1318	72	38	.	.	PROPN
dti-1318	72	39	1993	1993	NUM
dti-1318	72	40	;	;	PUNCT
dti-1318	72	41	park	park	NOUN
dti-1318	72	42	and	and	CCONJ
dti-1318	72	43	morrow	morrow	NOUN
dti-1318	72	44	,	,	PUNCT
dti-1318	72	45	1991	1991	NUM
dti-1318	72	46	)	)	PUNCT
dti-1318	72	47	.	.	PUNCT
dti-1318	73	1	the	the	DET
dti-1318	73	2	block	block	NOUN
dti-1318	73	3	in	in	ADP
dti-1318	73	4	virus	virus	NOUN
dti-1318	73	5	assembly	assembly	NOUN
dti-1318	73	6	is	be	AUX
dti-1318	73	7	partially	partially	ADV
dti-1318	73	8	overcome	overcome	VERB
dti-1318	73	9	by	by	ADP
dti-1318	73	10	inhibition	inhibition	NOUN
dti-1318	73	11	of	of	ADP
dti-1318	73	12	the	the	DET
dti-1318	73	13	hiv-1	hiv-1	ADJ
dti-1318	73	14	pr	pr	NOUN
dti-1318	73	15	,	,	PUNCT
dti-1318	73	16	suggesting	suggest	VERB
dti-1318	73	17	that	that	SCONJ
dti-1318	73	18	increased	increase	VERB
dti-1318	73	19	hiv-1	hiv-1	PUNCT
dti-1318	73	20	pr	pr	NOUN
dti-1318	73	21	activity	activity	NOUN
dti-1318	73	22	is	be	AUX
dti-1318	73	23	responsible	responsible	ADJ
dti-1318	73	24	for	for	ADP
dti-1318	73	25	the	the	DET
dti-1318	73	26	defect	defect	NOUN
dti-1318	73	27	(	(	PUNCT
dti-1318	73	28	karacostas	karacosta	NOUN
dti-1318	73	29	et	et	PROPN
dti-1318	73	30	al	al	PROPN
dti-1318	73	31	.	.	PROPN
dti-1318	73	32	1993	1993	NUM
dti-1318	73	33	)	)	PUNCT
dti-1318	73	34	.	.	PUNCT
dti-1318	74	1	a	a	DET
dti-1318	74	2	later	later	ADJ
dti-1318	74	3	study	study	NOUN
dti-1318	74	4	,	,	PUNCT
dti-1318	74	5	in	in	ADP
dti-1318	74	6	which	which	PRON
dti-1318	74	7	the	the	DET
dti-1318	74	8	impact	impact	NOUN
dti-1318	74	9	of	of	ADP
dti-1318	74	10	decreasing	decrease	VERB
dti-1318	74	11	the	the	DET
dti-1318	74	12	ratio	ratio	NOUN
dti-1318	74	13	of	of	ADP
dti-1318	74	14	gag	gag	NOUN
dti-1318	74	15	/	/	SYM
dti-1318	74	16	gag	gag	NOUN
dti-1318	74	17	-	-	PUNCT
dti-1318	74	18	pol	pol	NOUN
dti-1318	74	19	on	on	ADP
dti-1318	74	20	virion	virion	NOUN
dti-1318	74	21	production	production	NOUN
dti-1318	74	22	was	be	AUX
dti-1318	74	23	determined	determine	VERB
dti-1318	74	24	by	by	ADP
dti-1318	74	25	co	co	NOUN
dti-1318	74	26	-	-	NOUN
dti-1318	74	27	transfection	transfection	NOUN
dti-1318	74	28	of	of	ADP
dti-1318	74	29	plasmids	plasmid	NOUN
dti-1318	74	30	expressing	express	VERB
dti-1318	74	31	gag	gag	NOUN
dti-1318	74	32	and	and	CCONJ
dti-1318	74	33	gag	gag	NOUN
dti-1318	74	34	-	-	PUNCT
dti-1318	74	35	pol	pol	NOUN
dti-1318	74	36	alone	alone	ADV
dti-1318	74	37	demonstrate	demonstrate	VERB
dti-1318	74	38	that	that	SCONJ
dti-1318	74	39	the	the	DET
dti-1318	74	40	maintenance	maintenance	NOUN
dti-1318	74	41	of	of	ADP
dti-1318	74	42	this	this	DET
dti-1318	74	43	ratio	ratio	NOUN
dti-1318	74	44	is	be	AUX
dti-1318	74	45	not	not	PART
dti-1318	74	46	only	only	ADV
dti-1318	74	47	important	important	ADJ
dti-1318	74	48	for	for	ADP
dti-1318	74	49	hiv-1	hiv-1	VERB
dti-1318	74	50	replication	replication	NOUN
dti-1318	74	51	but	but	CCONJ
dti-1318	74	52	also	also	ADV
dti-1318	74	53	for	for	ADP
dti-1318	74	54	virion	virion	NOUN
dti-1318	74	55	rna	rna	NOUN
dti-1318	74	56	dimer	dimer	NOUN
dti-1318	74	57	formation	formation	NOUN
dti-1318	74	58	and	and	CCONJ
dti-1318	74	59	stability	stability	NOUN
dti-1318	74	60	(	(	PUNCT
dti-1318	74	61	shehu	shehu	NOUN
dti-1318	74	62	-	-	PUNCT
dti-1318	74	63	xhilaga	xhilaga	NOUN
dti-1318	74	64	et	et	PROPN
dti-1318	74	65	al	al	PROPN
dti-1318	74	66	.	.	PROPN
dti-1318	74	67	2001a	2001a	NUM
dti-1318	74	68	)	)	PUNCT
dti-1318	74	69	.	.	PUNCT
dti-1318	75	1	furthermore	furthermore	ADV
dti-1318	75	2	,	,	PUNCT
dti-1318	75	3	a	a	DET
dti-1318	75	4	decrease	decrease	NOUN
dti-1318	75	5	in	in	ADP
dti-1318	75	6	gag	gag	NOUN
dti-1318	75	7	-	-	PUNCT
dti-1318	75	8	pol	pol	NOUN
dti-1318	75	9	translation	translation	NOUN
dti-1318	75	10	results	result	VERB
dti-1318	75	11	in	in	ADP
dti-1318	75	12	major	major	ADJ
dti-1318	75	13	defects	defect	NOUN
dti-1318	75	14	in	in	ADP
dti-1318	75	15	virus	virus	NOUN
dti-1318	75	16	maturation	maturation	NOUN
dti-1318	75	17	and	and	CCONJ
dti-1318	75	18	hiv-1	hiv-1	PUNCT
dti-1318	75	19	infectivity	infectivity	NOUN
dti-1318	75	20	(	(	PUNCT
dti-1318	75	21	dulude	dulude	NOUN
dti-1318	75	22	et	et	PROPN
dti-1318	75	23	al	al	PROPN
dti-1318	75	24	.	.	PROPN
dti-1318	75	25	2006	2006	NUM
dti-1318	75	26	)	)	PUNCT
dti-1318	75	27	.	.	PUNCT
dti-1318	76	1	the	the	DET
dti-1318	76	2	small	small	ADJ
dti-1318	76	3	molecule	molecule	NOUN
dti-1318	76	4	,	,	PUNCT
dti-1318	76	5	1,4bis-[n-(3	1,4bis-[n-(3	NUM
dti-1318	76	6	-	-	PUNCT
dti-1318	76	7	n	n	CCONJ
dti-1318	76	8	,	,	PUNCT
dti-1318	76	9	n	n	CCONJ
dti-1318	76	10	-	-	PUNCT
dti-1318	76	11	dimethylpropyl)amidino]benzene	dimethylpropyl)amidino]benzene	ADJ
dti-1318	76	12	tetrahydrochloride	tetrahydrochloride	NOUN
dti-1318	76	13	(	(	PUNCT
dti-1318	76	14	rg501	rg501	NOUN
dti-1318	76	15	,	,	PUNCT
dti-1318	76	16	table	table	NOUN
dti-1318	76	17	1	1	NUM
dti-1318	76	18	)	)	PUNCT
dti-1318	76	19	,	,	PUNCT
dti-1318	76	20	is	be	AUX
dti-1318	76	21	thought	think	VERB
dti-1318	76	22	to	to	PART
dti-1318	76	23	enhance	enhance	VERB
dti-1318	76	24	ribosomal	ribosomal	NOUN
dti-1318	76	25	frameshifting	frameshifting	NOUN
dti-1318	76	26	of	of	ADP
dti-1318	76	27	hiv-1	hiv-1	PUNCT
dti-1318	76	28	by	by	ADP
dti-1318	76	29	binding	bind	VERB
dti-1318	76	30	to	to	ADP
dti-1318	76	31	the	the	DET
dti-1318	76	32	rna	rna	NOUN
dti-1318	76	33	stem	stem	NOUN
dti-1318	76	34	loop	loop	NOUN
dti-1318	76	35	structure	structure	NOUN
dti-1318	76	36	of	of	ADP
dti-1318	76	37	the	the	DET
dti-1318	76	38	ribosomal	ribosomal	NOUN
dti-1318	76	39	frameshifting	frameshifting	NOUN
dti-1318	76	40	signal	signal	NOUN
dti-1318	76	41	resulting	result	VERB
dti-1318	76	42	in	in	ADP
dti-1318	76	43	increased	increase	VERB
dti-1318	76	44	ribosomal	ribosomal	NOUN
dti-1318	76	45	pausing	pausing	NOUN
dti-1318	76	46	(	(	PUNCT
dti-1318	76	47	hung	hung	NOUN
dti-1318	76	48	et	et	PROPN
dti-1318	76	49	al	al	PROPN
dti-1318	76	50	.	.	PROPN
dti-1318	76	51	1998	1998	NUM
dti-1318	76	52	)	)	PUNCT
dti-1318	76	53	.	.	PUNCT
dti-1318	77	1	the	the	DET
dti-1318	77	2	imbalance	imbalance	NOUN
dti-1318	77	3	in	in	ADP
dti-1318	77	4	the	the	DET
dti-1318	77	5	resulting	result	VERB
dti-1318	77	6	gag	gag	NOUN
dti-1318	77	7	/	/	SYM
dti-1318	77	8	gag	gag	NOUN
dti-1318	77	9	-	-	PUNCT
dti-1318	77	10	pol	pol	NOUN
dti-1318	77	11	ratio	ratio	NOUN
dti-1318	77	12	is	be	AUX
dti-1318	77	13	associated	associate	VERB
dti-1318	77	14	with	with	ADP
dti-1318	77	15	inhibition	inhibition	NOUN
dti-1318	77	16	of	of	ADP
dti-1318	77	17	acute	acute	ADJ
dti-1318	77	18	and	and	CCONJ
dti-1318	77	19	chronic	chronic	ADJ
dti-1318	77	20	hiv-1	hiv-1	PART
dti-1318	77	21	infection	infection	NOUN
dti-1318	77	22	in	in	ADP
dti-1318	77	23	ccrf	ccrf	NOUN
dti-1318	77	24	-	-	PUNCT
dti-1318	77	25	cem	cem	NOUN
dti-1318	77	26	cells	cell	NOUN
dti-1318	77	27	and	and	CCONJ
dti-1318	77	28	peripheral	peripheral	ADJ
dti-1318	77	29	blood	blood	NOUN
dti-1318	77	30	mononuclear	mononuclear	ADJ
dti-1318	77	31	cells	cell	NOUN
dti-1318	77	32	.	.	PUNCT
dti-1318	78	1	targeting	target	VERB
dti-1318	78	2	gag	gag	NOUN
dti-1318	78	3	and	and	CCONJ
dti-1318	78	4	gag	gag	NOUN
dti-1318	78	5	-	-	PUNCT
dti-1318	78	6	pol	pol	NOUN
dti-1318	78	7	traffi	traffi	NOUN
dti-1318	78	8	cking	cke	VERB
dti-1318	78	9	during	during	ADP
dti-1318	78	10	the	the	DET
dti-1318	78	11	late	late	ADJ
dti-1318	78	12	phase	phase	NOUN
dti-1318	78	13	of	of	ADP
dti-1318	78	14	the	the	DET
dti-1318	78	15	viral	viral	ADJ
dti-1318	78	16	life	life	NOUN
dti-1318	78	17	cycle	cycle	NOUN
dti-1318	78	18	,	,	PUNCT
dti-1318	78	19	gag	gag	NOUN
dti-1318	78	20	polyproteins	polyprotein	NOUN
dti-1318	78	21	are	be	AUX
dti-1318	78	22	targeted	target	VERB
dti-1318	78	23	to	to	ADP
dti-1318	78	24	the	the	DET
dti-1318	78	25	plasma	plasma	NOUN
dti-1318	78	26	membrane	membrane	NOUN
dti-1318	78	27	,	,	PUNCT
dti-1318	78	28	where	where	SCONJ
dti-1318	78	29	they	they	PRON
dti-1318	78	30	are	be	AUX
dti-1318	78	31	believed	believe	VERB
dti-1318	78	32	to	to	PART
dti-1318	78	33	colocalise	colocalise	VERB
dti-1318	78	34	to	to	ADP
dti-1318	78	35	lipid	lipid	NOUN
dti-1318	78	36	raft	raft	NOUN
dti-1318	78	37	microdomains	microdomain	NOUN
dti-1318	78	38	for	for	ADP
dti-1318	78	39	assembly	assembly	NOUN
dti-1318	78	40	into	into	ADP
dti-1318	78	41	immature	immature	ADJ
dti-1318	78	42	virions	virion	NOUN
dti-1318	78	43	(	(	PUNCT
dti-1318	78	44	morikawa	morikawa	NOUN
dti-1318	78	45	et	et	PROPN
dti-1318	78	46	al	al	PROPN
dti-1318	78	47	.	.	PROPN
dti-1318	78	48	1996	1996	NUM
dti-1318	78	49	;	;	PUNCT
dti-1318	79	1	bryant	bryant	PROPN
dti-1318	79	2	and	and	CCONJ
dti-1318	79	3	ratner	ratner	PROPN
dti-1318	79	4	,	,	PUNCT
dti-1318	79	5	1990	1990	NUM
dti-1318	79	6	;	;	PUNCT
dti-1318	79	7	bouamr	bouamr	NOUN
dti-1318	79	8	et	et	PROPN
dti-1318	79	9	al	al	PROPN
dti-1318	79	10	.	.	PROPN
dti-1318	79	11	2003	2003	NUM
dti-1318	79	12	;	;	PUNCT
dti-1318	79	13	ding	de	VERB
dti-1318	79	14	et	et	PROPN
dti-1318	79	15	al	al	PROPN
dti-1318	79	16	.	.	PROPN
dti-1318	79	17	2003	2003	NUM
dti-1318	79	18	;	;	PUNCT
dti-1318	79	19	holm	holm	PROPN
dti-1318	79	20	et	et	PROPN
dti-1318	79	21	al	al	PROPN
dti-1318	79	22	.	.	PROPN
dti-1318	79	23	2003	2003	NUM
dti-1318	79	24	;	;	PUNCT
dti-1318	79	25	tang	tang	PROPN
dti-1318	79	26	et	et	PROPN
dti-1318	79	27	al	al	PROPN
dti-1318	79	28	.	.	PROPN
dti-1318	79	29	2004	2004	NUM
dti-1318	79	30	)	)	PUNCT
dti-1318	79	31	.	.	PUNCT
dti-1318	80	1	membrane	membrane	NOUN
dti-1318	80	2	targeting	targeting	NOUN
dti-1318	80	3	of	of	ADP
dti-1318	80	4	gag	gag	NOUN
dti-1318	80	5	is	be	AUX
dti-1318	80	6	mediated	mediate	VERB
dti-1318	80	7	by	by	ADP
dti-1318	80	8	the	the	DET
dti-1318	80	9	n	n	CCONJ
dti-1318	80	10	-	-	PUNCT
dti-1318	80	11	terminal	terminal	ADJ
dti-1318	80	12	myristoyl	myristoyl	PROPN
dti-1318	80	13	group	group	NOUN
dti-1318	80	14	in	in	ADP
dti-1318	80	15	concert	concert	NOUN
dti-1318	80	16	with	with	ADP
dti-1318	80	17	conserved	conserve	VERB
dti-1318	80	18	basic	basic	ADJ
dti-1318	80	19	amino	amino	NOUN
dti-1318	80	20	acids	acid	NOUN
dti-1318	80	21	at	at	ADP
dti-1318	80	22	the	the	DET
dti-1318	80	23	n	n	NOUN
dti-1318	80	24	-	-	PUNCT
dti-1318	80	25	terminus	terminus	NOUN
dti-1318	80	26	of	of	ADP
dti-1318	80	27	the	the	DET
dti-1318	80	28	ma	ma	PROPN
dti-1318	80	29	domain	domain	NOUN
dti-1318	80	30	of	of	ADP
dti-1318	80	31	gag	gag	PROPN
dti-1318	80	32	(	(	PUNCT
dti-1318	80	33	bryant	bryant	PROPN
dti-1318	80	34	and	and	CCONJ
dti-1318	80	35	ratner	ratner	PROPN
dti-1318	80	36	,	,	PUNCT
dti-1318	80	37	1990	1990	NUM
dti-1318	80	38	;	;	PUNCT
dti-1318	80	39	facke	facke	NOUN
dti-1318	80	40	et	et	PROPN
dti-1318	80	41	al	al	PROPN
dti-1318	80	42	.	.	PROPN
dti-1318	80	43	1993	1993	NUM
dti-1318	80	44	;	;	PUNCT
dti-1318	80	45	ono	ono	PROPN
dti-1318	80	46	and	and	CCONJ
dti-1318	80	47	freed	free	VERB
dti-1318	80	48	,	,	PUNCT
dti-1318	80	49	1999	1999	NUM
dti-1318	80	50	;	;	PUNCT
dti-1318	80	51	ono	ono	PROPN
dti-1318	80	52	et	et	PROPN
dti-1318	80	53	al	al	PROPN
dti-1318	80	54	.	.	PROPN
dti-1318	80	55	2000	2000	NUM
dti-1318	80	56	)	)	PUNCT
dti-1318	80	57	.	.	PUNCT
dti-1318	81	1	myristic	myristic	ADJ
dti-1318	81	2	acid	acid	PROPN
dti-1318	81	3	is	be	AUX
dti-1318	81	4	a	a	DET
dti-1318	81	5	saturated	saturate	VERB
dti-1318	81	6	14	14	NUM
dti-1318	81	7	-	-	PUNCT
dti-1318	81	8	carbon	carbon	NOUN
dti-1318	81	9	fatty	fatty	NOUN
dti-1318	81	10	acid	acid	NOUN
dti-1318	81	11	,	,	PUNCT
dti-1318	81	12	post	post	NOUN
dti-1318	81	13	transationally	transationally	ADV
dti-1318	81	14	attached	attach	VERB
dti-1318	81	15	to	to	ADP
dti-1318	81	16	the	the	DET
dti-1318	81	17	n	n	CCONJ
dti-1318	81	18	-	-	PUNCT
dti-1318	81	19	terminal	terminal	ADJ
dti-1318	81	20	glycine	glycine	NOUN
dti-1318	81	21	of	of	ADP
dti-1318	81	22	both	both	DET
dti-1318	81	23	gag	gag	NOUN
dti-1318	81	24	and	and	CCONJ
dti-1318	81	25	gag	gag	NOUN
dti-1318	81	26	-	-	PUNCT
dti-1318	81	27	pol	pol	NOUN
dti-1318	81	28	(	(	PUNCT
dti-1318	81	29	veronese	veronese	PROPN
dti-1318	81	30	et	et	PROPN
dti-1318	81	31	al	al	PROPN
dti-1318	81	32	.	.	PROPN
dti-1318	81	33	1988	1988	NUM
dti-1318	81	34	)	)	PUNCT
dti-1318	81	35	.	.	PUNCT
dti-1318	82	1	myristoylation	myristoylation	NOUN
dti-1318	82	2	of	of	ADP
dti-1318	82	3	gag	gag	NOUN
dti-1318	82	4	but	but	CCONJ
dti-1318	82	5	not	not	PART
dti-1318	82	6	gag	gag	NOUN
dti-1318	82	7	-	-	PUNCT
dti-1318	82	8	pol	pol	NOUN
dti-1318	82	9	is	be	AUX
dti-1318	82	10	critical	critical	ADJ
dti-1318	82	11	for	for	ADP
dti-1318	82	12	targeting	target	VERB
dti-1318	82	13	these	these	DET
dti-1318	82	14	polyproteins	polyprotein	NOUN
dti-1318	82	15	to	to	ADP
dti-1318	82	16	the	the	DET
dti-1318	82	17	plasma	plasma	NOUN
dti-1318	82	18	membrane	membrane	NOUN
dti-1318	82	19	(	(	PUNCT
dti-1318	82	20	park	park	NOUN
dti-1318	82	21	and	and	CCONJ
dti-1318	82	22	morrow	morrow	NOUN
dti-1318	82	23	,	,	PUNCT
dti-1318	82	24	1992	1992	NUM
dti-1318	82	25	;	;	PUNCT
dti-1318	82	26	smith	smith	PROPN
dti-1318	82	27	et	et	PROPN
dti-1318	82	28	al	al	PROPN
dti-1318	82	29	.	.	PROPN
dti-1318	82	30	1993	1993	NUM
dti-1318	82	31	)	)	PUNCT
dti-1318	82	32	.	.	PUNCT
dti-1318	83	1	mutations	mutation	NOUN
dti-1318	83	2	that	that	PRON
dti-1318	83	3	interfere	interfere	VERB
dti-1318	83	4	with	with	ADP
dti-1318	83	5	gag	gag	NOUN
dti-1318	83	6	myristoylation	myristoylation	NOUN
dti-1318	83	7	inhibit	inhibit	VERB
dti-1318	83	8	viral	viral	ADJ
dti-1318	83	9	budding	budding	NOUN
dti-1318	83	10	and	and	CCONJ
dti-1318	83	11	misdirect	misdirect	VERB
dti-1318	83	12	virion	virion	NOUN
dti-1318	83	13	assembly	assembly	NOUN
dti-1318	83	14	to	to	ADP
dti-1318	83	15	the	the	DET
dti-1318	83	16	cytosolic	cytosolic	ADJ
dti-1318	83	17	fraction	fraction	NOUN
dti-1318	83	18	(	(	PUNCT
dti-1318	83	19	gottlinger	gottlinger	NOUN
dti-1318	83	20	et	et	PROPN
dti-1318	83	21	al	al	PROPN
dti-1318	83	22	.	.	PROPN
dti-1318	83	23	1989	1989	NUM
dti-1318	83	24	;	;	PUNCT
dti-1318	83	25	bryant	bryant	PROPN
dti-1318	83	26	and	and	CCONJ
dti-1318	83	27	ratner	ratner	PROPN
dti-1318	83	28	,	,	PUNCT
dti-1318	83	29	1990	1990	NUM
dti-1318	83	30	)	)	PUNCT
dti-1318	83	31	.	.	PUNCT
dti-1318	84	1	however	however	ADV
dti-1318	84	2	,	,	PUNCT
dti-1318	84	3	complete	complete	ADJ
dti-1318	84	4	inhibition	inhibition	NOUN
dti-1318	84	5	of	of	ADP
dti-1318	84	6	gag	gag	NOUN
dti-1318	84	7	myristoylation	myristoylation	NOUN
dti-1318	84	8	is	be	AUX
dti-1318	84	9	necessary	necessary	ADJ
dti-1318	84	10	to	to	PART
dti-1318	84	11	block	block	VERB
dti-1318	84	12	hiv-1	hiv-1	ADV
dti-1318	84	13	budding	bud	VERB
dti-1318	84	14	(	(	PUNCT
dti-1318	84	15	morikawa	morikawa	NOUN
dti-1318	84	16	et	et	PROPN
dti-1318	84	17	al	al	PROPN
dti-1318	84	18	.	.	PROPN
dti-1318	84	19	1996	1996	NUM
dti-1318	84	20	)	)	PUNCT
dti-1318	84	21	.	.	PUNCT
dti-1318	85	1	myristoylation	myristoylation	NOUN
dti-1318	85	2	is	be	AUX
dti-1318	85	3	a	a	DET
dti-1318	85	4	two	two	NUM
dti-1318	85	5	-	-	PUNCT
dti-1318	85	6	step	step	NOUN
dti-1318	85	7	process	process	NOUN
dti-1318	85	8	involving	involve	VERB
dti-1318	85	9	activation	activation	NOUN
dti-1318	85	10	of	of	ADP
dti-1318	85	11	myristate	myristate	NOUN
dti-1318	85	12	to	to	ADP
dti-1318	85	13	myristoyl	myristoyl	VERB
dti-1318	85	14	-	-	PUNCT
dti-1318	85	15	coa	coa	NOUN
dti-1318	85	16	by	by	ADP
dti-1318	85	17	acylcoa	acylcoa	NOUN
dti-1318	85	18	synthetase	synthetase	NOUN
dti-1318	85	19	and	and	CCONJ
dti-1318	85	20	transfer	transfer	NOUN
dti-1318	85	21	of	of	ADP
dti-1318	85	22	the	the	DET
dti-1318	85	23	myristoyl	myristoyl	PROPN
dti-1318	85	24	moiety	moiety	NOUN
dti-1318	85	25	from	from	ADP
dti-1318	85	26	the	the	DET
dti-1318	85	27	myristoyl	myristoyl	ADJ
dti-1318	85	28	-	-	PUNCT
dti-1318	85	29	coa	coa	NOUN
dti-1318	85	30	substrate	substrate	NOUN
dti-1318	85	31	to	to	ADP
dti-1318	85	32	the	the	DET
dti-1318	85	33	n	n	CCONJ
dti-1318	85	34	-	-	PUNCT
dti-1318	85	35	terminal	terminal	ADJ
dti-1318	85	36	glycine	glycine	NOUN
dti-1318	85	37	of	of	ADP
dti-1318	85	38	gag	gag	NOUN
dti-1318	85	39	by	by	ADP
dti-1318	85	40	the	the	DET
dti-1318	85	41	enzyme	enzyme	NOUN
dti-1318	85	42	n	n	NOUN
dti-1318	85	43	-	-	PUNCT
dti-1318	85	44	myristoyltransferase	myristoyltransferase	NOUN
dti-1318	85	45	(	(	PUNCT
dti-1318	85	46	nmt	nmt	NOUN
dti-1318	85	47	)	)	PUNCT
dti-1318	85	48	(	(	PUNCT
dti-1318	85	49	morikawa	morikawa	NOUN
dti-1318	85	50	et	et	PROPN
dti-1318	85	51	al	al	PROPN
dti-1318	85	52	.	.	PROPN
dti-1318	85	53	1996	1996	NUM
dti-1318	85	54	;	;	PUNCT
dti-1318	85	55	veronese	veronese	PROPN
dti-1318	85	56	et	et	PROPN
dti-1318	85	57	al	al	PROPN
dti-1318	85	58	.	.	PROPN
dti-1318	85	59	1988	1988	NUM
dti-1318	85	60	)	)	PUNCT
dti-1318	85	61	.	.	PUNCT
dti-1318	86	1	this	this	DET
dti-1318	86	2	pathway	pathway	NOUN
dti-1318	86	3	has	have	AUX
dti-1318	86	4	been	be	AUX
dti-1318	86	5	utilized	utilize	VERB
dti-1318	86	6	to	to	PART
dti-1318	86	7	deliver	deliver	VERB
dti-1318	86	8	alternate	alternate	ADJ
dti-1318	86	9	myristoylation	myristoylation	NOUN
dti-1318	86	10	substrates	substrate	NOUN
dti-1318	86	11	that	that	PRON
dti-1318	86	12	perturb	perturb	VERB
dti-1318	86	13	viral	viral	ADJ
dti-1318	86	14	assembly	assembly	NOUN
dti-1318	86	15	.	.	PUNCT
dti-1318	87	1	the	the	DET
dti-1318	87	2	myristic	myristic	ADJ
dti-1318	87	3	acid	acid	NOUN
dti-1318	87	4	analogue	analogue	NOUN
dti-1318	87	5	12	12	NUM
dti-1318	87	6	-	-	PUNCT
dti-1318	87	7	azidododecanoic	azidododecanoic	NOUN
dti-1318	87	8	acid	acid	NOUN
dti-1318	87	9	is	be	AUX
dti-1318	87	10	a	a	DET
dti-1318	87	11	potent	potent	ADJ
dti-1318	87	12	inhibitor	inhibitor	NOUN
dti-1318	87	13	of	of	ADP
dti-1318	87	14	hiv-1	hiv-1	X
dti-1318	87	15	production	production	NOUN
dti-1318	87	16	in	in	ADP
dti-1318	87	17	acute	acute	ADJ
dti-1318	87	18	and	and	CCONJ
dti-1318	87	19	chronically	chronically	ADV
dti-1318	87	20	infected	infect	VERB
dti-1318	87	21	t	t	PROPN
dti-1318	87	22	-	-	PUNCT
dti-1318	87	23	cell	cell	NOUN
dti-1318	87	24	lines	line	NOUN
dti-1318	87	25	,	,	PUNCT
dti-1318	87	26	exhibiting	exhibit	VERB
dti-1318	87	27	a	a	DET
dti-1318	87	28	maximum	maximum	ADJ
dti-1318	87	29	inhibitory	inhibitory	ADJ
dti-1318	87	30	effect	effect	NOUN
dti-1318	87	31	between	between	ADP
dti-1318	87	32	10–50	10–50	NUM
dti-1318	87	33	µm	µm	ADP
dti-1318	87	34	at	at	ADP
dti-1318	87	35	noncytotoxic	noncytotoxic	ADJ
dti-1318	87	36	concentrations	concentration	NOUN
dti-1318	87	37	,	,	PUNCT
dti-1318	87	38	however	however	ADV
dti-1318	87	39	the	the	DET
dti-1318	87	40	mechanism	mechanism	NOUN
dti-1318	87	41	of	of	ADP
dti-1318	87	42	action	action	NOUN
dti-1318	87	43	is	be	AUX
dti-1318	87	44	not	not	PART
dti-1318	87	45	defi	defi	NOUN
dti-1318	87	46	ned	ned	PROPN
dti-1318	87	47	(	(	PUNCT
dti-1318	87	48	devadas	devadas	X
dti-1318	87	49	et	et	PROPN
dti-1318	87	50	al	al	PROPN
dti-1318	87	51	.	.	PROPN
dti-1318	87	52	1992	1992	NUM
dti-1318	87	53	)	)	PUNCT
dti-1318	87	54	.	.	PUNCT
dti-1318	88	1	another	another	DET
dti-1318	88	2	analogue	analogue	NOUN
dti-1318	88	3	,	,	PUNCT
dti-1318	88	4	4	4	NUM
dti-1318	88	5	-	-	PUNCT
dti-1318	88	6	oxatetra	oxatetra	ADV
dti-1318	88	7	-	-	ADJ
dti-1318	88	8	decanoic	decanoic	ADJ
dti-1318	88	9	acid	acid	NOUN
dti-1318	88	10	,	,	PUNCT
dti-1318	88	11	reduces	reduce	VERB
dti-1318	88	12	hiv-1	hiv-1	PART
dti-1318	88	13	replication	replication	NOUN
dti-1318	88	14	in	in	ADP
dti-1318	88	15	a	a	DET
dti-1318	88	16	t	t	NOUN
dti-1318	88	17	-	-	PUNCT
dti-1318	88	18	cell	cell	NOUN
dti-1318	88	19	line	line	NOUN
dti-1318	88	20	at	at	ADP
dti-1318	88	21	18	18	NUM
dti-1318	88	22	µm	µm	NOUN
dti-1318	88	23	(	(	PUNCT
dti-1318	88	24	langner	langner	NOUN
dti-1318	88	25	et	et	PROPN
dti-1318	88	26	al	al	PROPN
dti-1318	88	27	.	.	PROPN
dti-1318	88	28	1992	1992	NUM
dti-1318	88	29	)	)	PUNCT
dti-1318	88	30	.	.	PUNCT
dti-1318	89	1	heteroatom	heteroatom	NOUN
dti-1318	89	2	-	-	PUNCT
dti-1318	89	3	substituted	substitute	VERB
dti-1318	89	4	analogs	analog	NOUN
dti-1318	89	5	of	of	ADP
dti-1318	89	6	myristic	myristic	ADJ
dti-1318	89	7	acid	acid	NOUN
dti-1318	89	8	such	such	ADJ
dti-1318	89	9	as	as	ADP
dti-1318	89	10	12	12	NUM
dti-1318	89	11	-	-	PUNCT
dti-1318	89	12	methoxydodecanoate	methoxydodecanoate	NOUN
dti-1318	89	13	(	(	PUNCT
dti-1318	89	14	13	13	NUM
dti-1318	89	15	-	-	PUNCT
dti-1318	89	16	oxamyristate	oxamyristate	NOUN
dti-1318	89	17	or	or	CCONJ
dti-1318	89	18	13	13	NUM
dti-1318	89	19	-	-	PUNCT
dti-1318	89	20	oxamyr	oxamyr	NOUN
dti-1318	89	21	)	)	PUNCT
dti-1318	89	22	,	,	PUNCT
dti-1318	89	23	5	5	NUM
dti-1318	89	24	-	-	PUNCT
dti-1318	89	25	octyloxypentanoate	octyloxypentanoate	ADJ
dti-1318	89	26	(	(	PUNCT
dti-1318	89	27	6	6	NUM
dti-1318	89	28	-	-	PUNCT
dti-1318	89	29	oxamyristate	oxamyristate	NOUN
dti-1318	89	30	or	or	CCONJ
dti-1318	89	31	6	6	NUM
dti-1318	89	32	-	-	PUNCT
dti-1318	89	33	oxamyr	oxamyr	NOUN
dti-1318	89	34	)	)	PUNCT
dti-1318	89	35	,	,	PUNCT
dti-1318	89	36	11	11	NUM
dti-1318	89	37	-	-	PUNCT
dti-1318	89	38	ethylthioundecanoic	ethylthioundecanoic	ADJ
dti-1318	89	39	acid	acid	NOUN
dti-1318	89	40	and	and	CCONJ
dti-1318	89	41	12	12	NUM
dti-1318	89	42	-	-	PUNCT
dti-1318	89	43	thioethyldodecanoic	thioethyldodecanoic	NOUN
dti-1318	89	44	acid	acid	NOUN
dti-1318	89	45	act	act	NOUN
dti-1318	89	46	as	as	ADP
dti-1318	89	47	alternate	alternate	ADJ
dti-1318	89	48	substrates	substrate	NOUN
dti-1318	89	49	for	for	ADP
dti-1318	89	50	gag	gag	NOUN
dti-1318	89	51	myristoylation	myristoylation	NOUN
dti-1318	89	52	(	(	PUNCT
dti-1318	89	53	bryant	bryant	PROPN
dti-1318	89	54	et	et	PROPN
dti-1318	89	55	al	al	PROPN
dti-1318	89	56	.	.	PROPN
dti-1318	89	57	1989	1989	NUM
dti-1318	89	58	;	;	PUNCT
dti-1318	89	59	bryant	bryant	PROPN
dti-1318	89	60	et	et	PROPN
dti-1318	89	61	al	al	PROPN
dti-1318	89	62	.	.	PROPN
dti-1318	89	63	1991	1991	NUM
dti-1318	89	64	;	;	PUNCT
dti-1318	89	65	parang	parang	PROPN
dti-1318	89	66	et	et	PROPN
dti-1318	89	67	al	al	PROPN
dti-1318	89	68	.	.	PROPN
dti-1318	89	69	1997	1997	NUM
dti-1318	89	70	)	)	PUNCT
dti-1318	90	1	and	and	CCONJ
dti-1318	90	2	can	can	AUX
dti-1318	90	3	prevent	prevent	VERB
dti-1318	90	4	membrane	membrane	NOUN
dti-1318	90	5	binding	binding	NOUN
dti-1318	90	6	of	of	ADP
dti-1318	90	7	the	the	DET
dti-1318	90	8	modifi	modifi	PROPN
dti-1318	90	9	ed	ed	PROPN
dti-1318	90	10	gag	gag	NOUN
dti-1318	90	11	proteins	protein	NOUN
dti-1318	90	12	(	(	PUNCT
dti-1318	90	13	bryant	bryant	PROPN
dti-1318	90	14	et	et	PROPN
dti-1318	90	15	al	al	PROPN
dti-1318	90	16	.	.	PROPN
dti-1318	90	17	1989	1989	NUM
dti-1318	90	18	;	;	PUNCT
dti-1318	90	19	bryant	bryant	PROPN
dti-1318	90	20	et	et	PROPN
dti-1318	90	21	al	al	PROPN
dti-1318	90	22	.	.	PROPN
dti-1318	90	23	1991	1991	NUM
dti-1318	90	24	)	)	PUNCT
dti-1318	90	25	.	.	PUNCT
dti-1318	91	1	of	of	ADP
dti-1318	91	2	the	the	DET
dti-1318	91	3	heteroatom	heteroatom	NOUN
dti-1318	91	4	substituted	substitute	VERB
dti-1318	91	5	analogs	analog	NOUN
dti-1318	91	6	,	,	PUNCT
dti-1318	91	7	13	13	NUM
dti-1318	91	8	-	-	PUNCT
dti-1318	91	9	oxamyr	oxamyr	NOUN
dti-1318	91	10	is	be	AUX
dti-1318	91	11	the	the	DET
dti-1318	91	12	most	most	ADV
dti-1318	91	13	potent	potent	ADJ
dti-1318	91	14	inhibitor	inhibitor	NOUN
dti-1318	91	15	.	.	PUNCT
dti-1318	92	1	13	13	NUM
dti-1318	92	2	-	-	PUNCT
dti-1318	92	3	oxamyr	oxamyr	NOUN
dti-1318	92	4	is	be	AUX
dti-1318	92	5	added	add	VERB
dti-1318	92	6	to	to	PART
dti-1318	92	7	gag	gag	VERB
dti-1318	92	8	with	with	ADP
dti-1318	92	9	an	an	DET
dti-1318	92	10	effi	effi	PROPN
dti-1318	92	11	cacy	cacy	NOUN
dti-1318	92	12	similar	similar	ADJ
dti-1318	92	13	to	to	ADP
dti-1318	92	14	that	that	PRON
dti-1318	92	15	of	of	ADP
dti-1318	92	16	myristate	myristate	NOUN
dti-1318	92	17	and	and	CCONJ
dti-1318	92	18	alters	alter	VERB
dti-1318	92	19	viral	viral	ADJ
dti-1318	92	20	polyprotein	polyprotein	ADJ
dti-1318	92	21	processing	processing	NOUN
dti-1318	92	22	,	,	PUNCT
dti-1318	92	23	which	which	PRON
dti-1318	92	24	is	be	AUX
dti-1318	92	25	suggested	suggest	VERB
dti-1318	92	26	to	to	PART
dti-1318	92	27	be	be	AUX
dti-1318	92	28	a	a	DET
dti-1318	92	29	consequence	consequence	NOUN
dti-1318	92	30	of	of	ADP
dti-1318	92	31	inhibiting	inhibit	VERB
dti-1318	92	32	gag	gag	NOUN
dti-1318	92	33	and	and	CCONJ
dti-1318	92	34	163	163	NUM
dti-1318	92	35	targeting	target	VERB
dti-1318	92	36	the	the	DET
dti-1318	92	37	late	late	ADJ
dti-1318	92	38	stages	stage	NOUN
dti-1318	92	39	of	of	ADP
dti-1318	92	40	hiv-1	hiv-1	X
dti-1318	92	41	replication	replication	NOUN
dti-1318	92	42	drug	drug	NOUN
dti-1318	92	43	target	target	NOUN
dti-1318	92	44	insights	insight	NOUN
dti-1318	92	45	2007	2007	NUM
dti-1318	92	46	:	:	PUNCT
dti-1318	92	47	2	2	NUM
dti-1318	92	48	table	table	NOUN
dti-1318	92	49	1	1	NUM
dti-1318	92	50	.	.	PUNCT
dti-1318	93	1	inhibitors	inhibitor	NOUN
dti-1318	93	2	of	of	ADP
dti-1318	93	3	the	the	DET
dti-1318	93	4	late	late	ADJ
dti-1318	93	5	stages	stage	NOUN
dti-1318	93	6	of	of	ADP
dti-1318	93	7	hiv-1	hiv-1	X
dti-1318	93	8	replication	replication	NOUN
dti-1318	93	9	.	.	PUNCT
dti-1318	94	1	inhibitor	inhibitor	NOUN
dti-1318	94	2	description	description	NOUN
dti-1318	94	3	reference	reference	NOUN
dti-1318	94	4	ribosomal	ribosomal	NOUN
dti-1318	94	5	frameshifting	frameshifte	VERB
dti-1318	94	6	1,4	1,4	NUM
dti-1318	94	7	-	-	PUNCT
dti-1318	94	8	bis-[n-(3	bis-[n-(3	NUM
dti-1318	94	9	-	-	PUNCT
dti-1318	94	10	n	n	CCONJ
dti-1318	94	11	,	,	PUNCT
dti-1318	94	12	n	n	DET
dti-1318	94	13	small	small	ADJ
dti-1318	94	14	molecule	molecule	NOUN
dti-1318	94	15	(	(	PUNCT
dti-1318	94	16	hung	hung	NOUN
dti-1318	94	17	et	et	PROPN
dti-1318	94	18	al	al	PROPN
dti-1318	94	19	.	.	PROPN
dti-1318	94	20	1998	1998	NUM
dti-1318	94	21	)	)	PUNCT
dti-1318	94	22	.	.	PUNCT
dti-1318	95	1	dimethylpropyl)amidino]benzene	dimethylpropyl)amidino]benzene	ADJ
dti-1318	95	2	tetrahydrochloride	tetrahydrochloride	NOUN
dti-1318	95	3	(	(	PUNCT
dti-1318	95	4	rg501	rg501	PROPN
dti-1318	95	5	)	)	PUNCT
dti-1318	95	6	myristoylation	myristoylation	NOUN
dti-1318	95	7	and	and	CCONJ
dti-1318	95	8	traffi	traffi	NOUN
dti-1318	95	9	cking	cke	VERB
dti-1318	95	10	12	12	NUM
dti-1318	95	11	-	-	PUNCT
dti-1318	95	12	azidododecanoic	azidododecanoic	NOUN
dti-1318	95	13	acid	acid	NOUN
dti-1318	95	14	myristic	myristic	ADJ
dti-1318	95	15	acid	acid	NOUN
dti-1318	95	16	analogue	analogue	NOUN
dti-1318	95	17	(	(	PUNCT
dti-1318	95	18	devadas	devadas	PROPN
dti-1318	95	19	et	et	PROPN
dti-1318	95	20	al	al	PROPN
dti-1318	95	21	.	.	PROPN
dti-1318	95	22	1992	1992	NUM
dti-1318	95	23	)	)	PUNCT
dti-1318	95	24	4	4	NUM
dti-1318	95	25	-	-	PUNCT
dti-1318	95	26	oxatetra	oxatetra	ADV
dti-1318	95	27	-	-	ADJ
dti-1318	95	28	decanoic	decanoic	ADJ
dti-1318	95	29	acid	acid	NOUN
dti-1318	95	30	(	(	PUNCT
dti-1318	95	31	langner	langner	NOUN
dti-1318	95	32	et	et	PROPN
dti-1318	95	33	al	al	PROPN
dti-1318	95	34	.	.	PROPN
dti-1318	95	35	1992	1992	NUM
dti-1318	95	36	)	)	PUNCT
dti-1318	95	37	12	12	NUM
dti-1318	95	38	-	-	PUNCT
dti-1318	95	39	methoxydodecanoate	methoxydodecanoate	NOUN
dti-1318	95	40	heteroatom	heteroatom	NOUN
dti-1318	95	41	-	-	PUNCT
dti-1318	95	42	substituted	substitute	VERB
dti-1318	95	43	(	(	PUNCT
dti-1318	95	44	bryant	bryant	PROPN
dti-1318	95	45	et	et	PROPN
dti-1318	95	46	al	al	PROPN
dti-1318	95	47	.	.	PROPN
dti-1318	95	48	1989	1989	NUM
dti-1318	95	49	)	)	PUNCT
dti-1318	95	50	5	5	NUM
dti-1318	95	51	-	-	PUNCT
dti-1318	95	52	ocytl	ocytl	NOUN
dti-1318	95	53	-	-	PUNCT
dti-1318	95	54	oxypentanoate	oxypentanoate	NOUN
dti-1318	95	55	myristic	myristic	ADJ
dti-1318	95	56	acid	acid	NOUN
dti-1318	95	57	analogues	analogue	NOUN
dti-1318	95	58	(	(	PUNCT
dti-1318	95	59	bryant	bryant	PROPN
dti-1318	95	60	et	et	PROPN
dti-1318	95	61	al	al	PROPN
dti-1318	95	62	.	.	PROPN
dti-1318	95	63	1991	1991	NUM
dti-1318	95	64	)	)	PUNCT
dti-1318	95	65	11	11	NUM
dti-1318	95	66	-	-	PUNCT
dti-1318	95	67	ethylthioundecanoic	ethylthioundecanoic	ADJ
dti-1318	95	68	acid	acid	NOUN
dti-1318	95	69	(	(	PUNCT
dti-1318	95	70	parang	parang	PROPN
dti-1318	95	71	et	et	PROPN
dti-1318	95	72	al	al	PROPN
dti-1318	95	73	.	.	PROPN
dti-1318	95	74	1997	1997	NUM
dti-1318	95	75	)	)	PUNCT
dti-1318	95	76	12	12	NUM
dti-1318	95	77	-	-	PUNCT
dti-1318	95	78	thioethyldodecanoic	thioethyldodecanoic	NOUN
dti-1318	95	79	acid	acid	NOUN
dti-1318	95	80	5	5	NUM
dti-1318	95	81	-	-	PUNCT
dti-1318	95	82	cis	cis	NOUN
dti-1318	95	83	-	-	PUNCT
dti-1318	95	84	tetradecenoic	tetradecenoic	ADJ
dti-1318	95	85	acid	acid	NOUN
dti-1318	95	86	unsaturated	unsaturate	VERB
dti-1318	95	87	14	14	NUM
dti-1318	95	88	-	-	PUNCT
dti-1318	95	89	carbon	carbon	NOUN
dti-1318	95	90	(	(	PUNCT
dti-1318	95	91	lindwasser	lindwasser	ADJ
dti-1318	95	92	and	and	CCONJ
dti-1318	95	93	resh	resh	NOUN
dti-1318	95	94	,	,	PUNCT
dti-1318	95	95	2002	2002	NUM
dti-1318	95	96	)	)	PUNCT
dti-1318	95	97	.	.	PUNCT
dti-1318	96	1	(	(	PUNCT
dti-1318	96	2	physeteric	physeteric	ADJ
dti-1318	96	3	acid	acid	NOUN
dti-1318	96	4	)	)	PUNCT
dti-1318	96	5	fatty	fatty	NOUN
dti-1318	96	6	acids	acids	ADJ
dti-1318	96	7	5	5	NUM
dti-1318	96	8	-	-	PUNCT
dti-1318	96	9	cis,8	cis,8	NOUN
dti-1318	96	10	-	-	PUNCT
dti-1318	96	11	cis	cis	NOUN
dti-1318	96	12	-	-	PUNCT
dti-1318	96	13	tetradecenoic	tetradecenoic	ADJ
dti-1318	96	14	acid	acid	NOUN
dti-1318	96	15	(	(	PUNCT
dti-1318	96	16	goshuyic	goshuyic	ADJ
dti-1318	96	17	acid	acid	NOUN
dti-1318	96	18	)	)	PUNCT
dti-1318	96	19	assembly	assembly	NOUN
dti-1318	96	20	—	—	PUNCT
dti-1318	96	21	gag	gag	NOUN
dti-1318	96	22	/	/	SYM
dti-1318	96	23	gag	gag	NOUN
dti-1318	96	24	interactions	interaction	NOUN
dti-1318	96	25	cap-1	cap-1	PRON
dti-1318	96	26	small	small	ADJ
dti-1318	96	27	molecule	molecule	NOUN
dti-1318	96	28	(	(	PUNCT
dti-1318	96	29	tang	tang	NOUN
dti-1318	96	30	et	et	PROPN
dti-1318	96	31	al	al	PROPN
dti-1318	96	32	.	.	PROPN
dti-1318	96	33	2003	2003	NUM
dti-1318	96	34	)	)	PUNCT
dti-1318	96	35	paatleemmta	paatleemmta	NOUN
dti-1318	96	36	ca	can	AUX
dti-1318	96	37	derived	derive	VERB
dti-1318	96	38	peptide	peptide	NOUN
dti-1318	96	39	(	(	PUNCT
dti-1318	96	40	niedrig	niedrig	PROPN
dti-1318	96	41	et	et	PROPN
dti-1318	96	42	al	al	PROPN
dti-1318	96	43	.	.	PROPN
dti-1318	96	44	1994	1994	NUM
dti-1318	96	45	)	)	PUNCT
dti-1318	96	46	.	.	PUNCT
dti-1318	97	1	gpg	gpg	AUX
dti-1318	97	2	-	-	PUNCT
dti-1318	97	3	nh2	nh2	NOUN
dti-1318	97	4	ca	can	AUX
dti-1318	97	5	derived	derive	VERB
dti-1318	97	6	tripeptide	tripeptide	NOUN
dti-1318	97	7	amide	amide	NOUN
dti-1318	97	8	(	(	PUNCT
dti-1318	97	9	hoglund	hoglund	NOUN
dti-1318	97	10	et	et	PROPN
dti-1318	97	11	al	al	PROPN
dti-1318	97	12	.	.	PROPN
dti-1318	97	13	2002	2002	NUM
dti-1318	97	14	)	)	PUNCT
dti-1318	98	1	cai	cai	PROPN
dti-1318	98	2	peptide	peptide	NOUN
dti-1318	98	3	(	(	PUNCT
dti-1318	98	4	sticht	sticht	PROPN
dti-1318	98	5	et	et	PROPN
dti-1318	98	6	al	al	PROPN
dti-1318	98	7	.	.	PROPN
dti-1318	98	8	2005	2005	NUM
dti-1318	98	9	)	)	PUNCT
dti-1318	98	10	(	(	PUNCT
dti-1318	98	11	ternois	ternois	NOUN
dti-1318	98	12	et	et	PROPN
dti-1318	98	13	al	al	PROPN
dti-1318	98	14	.	.	PROPN
dti-1318	98	15	2005	2005	NUM
dti-1318	98	16	)	)	PUNCT
dti-1318	98	17	maturation	maturation	NOUN
dti-1318	98	18	—	—	PUNCT
dti-1318	98	19	gag	gag	NOUN
dti-1318	98	20	processing	processing	NOUN
dti-1318	98	21	3	3	NUM
dti-1318	98	22	-	-	ADJ
dti-1318	98	23	0-(3′-3′-dimethylsuccinyl)-betulinic	0-(3′-3′-dimethylsuccinyl)-betulinic	ADJ
dti-1318	98	24	small	small	ADJ
dti-1318	98	25	molecule	molecule	NOUN
dti-1318	98	26	(	(	PUNCT
dti-1318	98	27	li	li	PROPN
dti-1318	98	28	et	et	PROPN
dti-1318	98	29	al	al	PROPN
dti-1318	98	30	.	.	PROPN
dti-1318	98	31	2003	2003	NUM
dti-1318	98	32	)	)	PUNCT
dti-1318	98	33	acid	acid	NOUN
dti-1318	98	34	(	(	PUNCT
dti-1318	98	35	zhou	zhou	PROPN
dti-1318	98	36	et	et	PROPN
dti-1318	98	37	al	al	PROPN
dti-1318	98	38	.	.	PROPN
dti-1318	98	39	2004	2004	NUM
dti-1318	98	40	)	)	PUNCT
dti-1318	98	41	(	(	PUNCT
dti-1318	98	42	pa-457	pa-457	PROPN
dti-1318	98	43	/	/	SYM
dti-1318	98	44	bevirimat	bevirimat	NOUN
dti-1318	98	45	)	)	PUNCT
dti-1318	98	46	(	(	PUNCT
dti-1318	98	47	sakalian	sakalian	NOUN
dti-1318	98	48	et	et	PROPN
dti-1318	98	49	al	al	PROPN
dti-1318	98	50	.	.	PROPN
dti-1318	98	51	2006	2006	NUM
dti-1318	98	52	)	)	PUNCT
dti-1318	98	53	electrophilic	electrophilic	ADJ
dti-1318	98	54	disulfi	disulfi	NOUN
dti-1318	98	55	de	de	X
dti-1318	98	56	-	-	ADJ
dti-1318	98	57	substituted	substitute	VERB
dti-1318	98	58	nc	nc	PROPN
dti-1318	98	59	zn	zn	PROPN
dti-1318	98	60	fi	fi	NOUN
dti-1318	98	61	nger	nger	ADJ
dti-1318	98	62	inhibitor	inhibitor	NOUN
dti-1318	98	63	(	(	PUNCT
dti-1318	98	64	rice	rice	NOUN
dti-1318	98	65	et	et	PROPN
dti-1318	98	66	al	al	PROPN
dti-1318	98	67	.	.	PROPN
dti-1318	98	68	1995	1995	NUM
dti-1318	98	69	)	)	PUNCT
dti-1318	98	70	benzamides	benzamide	NOUN
dti-1318	98	71	(	(	PUNCT
dti-1318	98	72	dibas	dibas	PROPN
dti-1318	98	73	)	)	PUNCT
dti-1318	98	74	(	(	PUNCT
dti-1318	98	75	turpin	turpin	NOUN
dti-1318	98	76	et	et	PROPN
dti-1318	98	77	al	al	PROPN
dti-1318	98	78	.	.	PROPN
dti-1318	98	79	1996	1996	NUM
dti-1318	98	80	)	)	PUNCT
dti-1318	99	1	1,2	1,2	NUM
dti-1318	99	2	-	-	PUNCT
dti-1318	99	3	dithiane-4,5	dithiane-4,5	VERB
dti-1318	99	4	-	-	PUNCT
dti-1318	99	5	diol,1,1	diol,1,1	NOUN
dti-1318	99	6	-	-	PUNCT
dti-1318	99	7	dioxide	dioxide	NOUN
dti-1318	99	8	nc	nc	PROPN
dti-1318	99	9	zn	zn	PROPN
dti-1318	99	10	fi	fi	NOUN
dti-1318	99	11	nger	nger	ADJ
dti-1318	99	12	inhibitor	inhibitor	NOUN
dti-1318	99	13	(	(	PUNCT
dti-1318	99	14	rice	rice	NOUN
dti-1318	99	15	et	et	PROPN
dti-1318	99	16	al	al	PROPN
dti-1318	99	17	.	.	PROPN
dti-1318	99	18	1997	1997	NUM
dti-1318	99	19	)	)	PUNCT
dti-1318	99	20	(	(	PUNCT
dti-1318	99	21	nsc	nsc	PROPN
dti-1318	99	22	624151	624151	NUM
dti-1318	99	23	)	)	PUNCT
dti-1318	99	24	s	s	X
dti-1318	99	25	-	-	PUNCT
dti-1318	99	26	acyl	acyl	ADJ
dti-1318	99	27	2	2	NUM
dti-1318	99	28	-	-	PUNCT
dti-1318	99	29	mercaptobenzamide	mercaptobenzamide	NOUN
dti-1318	99	30	thioester	thioester	NOUN
dti-1318	99	31	nc	nc	PROPN
dti-1318	99	32	zn	zn	PROPN
dti-1318	99	33	fi	fi	NOUN
dti-1318	99	34	nger	nger	ADJ
dti-1318	99	35	inhibitor	inhibitor	NOUN
dti-1318	99	36	(	(	PUNCT
dti-1318	99	37	schito	schito	VERB
dti-1318	99	38	et	et	PROPN
dti-1318	99	39	al	al	PROPN
dti-1318	99	40	.	.	PROPN
dti-1318	99	41	2006	2006	NUM
dti-1318	99	42	)	)	PUNCT
dti-1318	99	43	.	.	PUNCT
dti-1318	100	1	(	(	PUNCT
dti-1318	100	2	samt	samt	PROPN
dti-1318	100	3	)	)	PUNCT
dti-1318	100	4	maturation	maturation	NOUN
dti-1318	100	5	—	—	PUNCT
dti-1318	100	6	pr	pr	NOUN
dti-1318	100	7	dimerisation	dimerisation	NOUN
dti-1318	100	8	ac	ac	PROPN
dti-1318	100	9	-	-	PROPN
dti-1318	100	10	tlnf	tlnf	PROPN
dti-1318	100	11	-	-	PROPN
dti-1318	101	1	oh	oh	INTJ
dti-1318	101	2	pr	pr	NOUN
dti-1318	101	3	c	c	NOUN
dti-1318	101	4	-	-	PUNCT
dti-1318	101	5	terminal	terminal	ADJ
dti-1318	101	6	tetrapeptide	tetrapeptide	ADV
dti-1318	101	7	(	(	PUNCT
dti-1318	101	8	zhang	zhang	PROPN
dti-1318	101	9	et	et	PROPN
dti-1318	101	10	al	al	PROPN
dti-1318	101	11	.	.	PROPN
dti-1318	101	12	1991	1991	NUM
dti-1318	101	13	)	)	PUNCT
dti-1318	101	14	pal	pal	ADJ
dti-1318	101	15	-	-	PUNCT
dti-1318	101	16	ydl	ydl	ADJ
dti-1318	101	17	-	-	PUNCT
dti-1318	101	18	oh	oh	NOUN
dti-1318	101	19	modifi	modifi	NOUN
dti-1318	101	20	ed	ed	PROPN
dti-1318	101	21	pr	pr	PRON
dti-1318	102	1	c	c	NOUN
dti-1318	102	2	-	-	PUNCT
dti-1318	102	3	terminal	terminal	ADJ
dti-1318	102	4	(	(	PUNCT
dti-1318	102	5	schramm	schramm	PROPN
dti-1318	102	6	et	et	PROPN
dti-1318	102	7	al	al	PROPN
dti-1318	102	8	.	.	PROPN
dti-1318	102	9	1999	1999	NUM
dti-1318	102	10	)	)	PUNCT
dti-1318	102	11	pal	pal	ADJ
dti-1318	102	12	-	-	PUNCT
dti-1318	102	13	yd-(biphenylalaine)-oh	yd-(biphenylalaine)-oh	PROPN
dti-1318	102	14	lipopeptides	lipopeptides	PROPN
dti-1318	102	15	pal	pal	ADJ
dti-1318	102	16	-	-	PUNCT
dti-1318	102	17	ydt	ydt	ADJ
dti-1318	102	18	-	-	PUNCT
dti-1318	102	19	oh	oh	PROPN
dti-1318	102	20	apam(2)-yd	apam(2)-yd	NOUN
dti-1318	102	21	-	-	PUNCT
dti-1318	102	22	thyroxine	thyroxine	NOUN
dti-1318	102	23	-	-	PUNCT
dti-1318	102	24	oh	oh	INTJ
dti-1318	102	25	(	(	PUNCT
dti-1318	102	26	dumond	dumond	NOUN
dti-1318	102	27	et	et	PROPN
dti-1318	102	28	al	al	PROPN
dti-1318	102	29	.	.	PROPN
dti-1318	102	30	2003	2003	NUM
dti-1318	102	31	)	)	PUNCT
dti-1318	102	32	pqitl(ggg)ctlnf	pqitl(ggg)ctlnf	NOUN
dti-1318	102	33	glycine	glycine	NOUN
dti-1318	102	34	linked	link	VERB
dti-1318	102	35	pr	pr	NOUN
dti-1318	102	36	interface	interface	NOUN
dti-1318	102	37	(	(	PUNCT
dti-1318	102	38	babe	babe	NOUN
dti-1318	102	39	et	et	PROPN
dti-1318	102	40	al	al	PROPN
dti-1318	102	41	.	.	PROPN
dti-1318	102	42	1992	1992	NUM
dti-1318	102	43	)	)	PUNCT
dti-1318	102	44	tetra	tetra	NOUN
dti-1318	102	45	-	-	PUNCT
dti-1318	102	46	peptides	peptide	NOUN
dti-1318	102	47	ho	ho	ADJ
dti-1318	102	48	-	-	PUNCT
dti-1318	102	49	fnlts	fnlt	NOUN
dti-1318	102	50	-	-	PUNCT
dti-1318	102	51	nh-(ch2)n	nh-(ch2)n	VERB
dti-1318	102	52	-	-	PUNCT
dti-1318	102	53	n	n	CCONJ
dti-1318	102	54	-	-	PUNCT
dti-1318	102	55	pqitlw	pqitlw	NOUN
dti-1318	102	56	-	-	PUNCT
dti-1318	102	57	oh	oh	NOUN
dti-1318	102	58	alkyl	alkyl	NOUN
dti-1318	102	59	linked	link	VERB
dti-1318	102	60	pr	pr	NOUN
dti-1318	102	61	interface	interface	NOUN
dti-1318	102	62	(	(	PUNCT
dti-1318	102	63	zutshi	zutshi	PROPN
dti-1318	102	64	et	et	PROPN
dti-1318	102	65	al	al	PROPN
dti-1318	102	66	.	.	PROPN
dti-1318	102	67	1997	1997	NUM
dti-1318	102	68	)	)	PUNCT
dti-1318	103	1	peptides	peptide	NOUN
dti-1318	103	2	(	(	PUNCT
dti-1318	103	3	ulysse	ulysse	NOUN
dti-1318	103	4	and	and	CCONJ
dti-1318	103	5	chmielewski	chmielewski	ADJ
dti-1318	103	6	,	,	PUNCT
dti-1318	103	7	1998	1998	NUM
dti-1318	103	8	)	)	PUNCT
dti-1318	103	9	(	(	PUNCT
dti-1318	103	10	zutshi	zutshi	NOUN
dti-1318	103	11	and	and	CCONJ
dti-1318	103	12	chmielewski	chmielewski	ADJ
dti-1318	103	13	,	,	PUNCT
dti-1318	103	14	2000	2000	NUM
dti-1318	103	15	)	)	PUNCT
dti-1318	103	16	(	(	PUNCT
dti-1318	103	17	continued	continue	VERB
dti-1318	103	18	)	)	PUNCT
dti-1318	103	19	164	164	NUM
dti-1318	103	20	wapling	waple	VERB
dti-1318	103	21	et	et	PROPN
dti-1318	103	22	al	al	PROPN
dti-1318	103	23	drug	drug	PROPN
dti-1318	103	24	target	target	NOUN
dti-1318	103	25	insights	insight	NOUN
dti-1318	103	26	2007	2007	NUM
dti-1318	103	27	:	:	PUNCT
dti-1318	103	28	2	2	NUM
dti-1318	103	29	molecular	molecular	ADJ
dti-1318	103	30	tongs	tong	NOUN
dti-1318	103	31	scaffold	scaffold	NOUN
dti-1318	103	32	constrained	constrain	VERB
dti-1318	103	33	pr	pr	NOUN
dti-1318	103	34	(	(	PUNCT
dti-1318	103	35	bouras	boura	NOUN
dti-1318	103	36	et	et	PROPN
dti-1318	103	37	al	al	PROPN
dti-1318	103	38	.	.	PROPN
dti-1318	103	39	1999	1999	NUM
dti-1318	103	40	)	)	PUNCT
dti-1318	103	41	interface	interface	NOUN
dti-1318	103	42	peptides	peptide	NOUN
dti-1318	103	43	(	(	PUNCT
dti-1318	103	44	breccia	breccia	NOUN
dti-1318	103	45	et	et	PROPN
dti-1318	103	46	al	al	PROPN
dti-1318	103	47	.	.	PROPN
dti-1318	103	48	2003	2003	NUM
dti-1318	103	49	)	)	PUNCT
dti-1318	104	1	(	(	PUNCT
dti-1318	104	2	merabet	merabet	NOUN
dti-1318	104	3	et	et	PROPN
dti-1318	104	4	al	al	PROPN
dti-1318	104	5	.	.	PROPN
dti-1318	104	6	2004	2004	NUM
dti-1318	104	7	)	)	PUNCT
dti-1318	105	1	(	(	PUNCT
dti-1318	105	2	hwang	hwang	PROPN
dti-1318	105	3	and	and	CCONJ
dti-1318	105	4	chmielewski	chmielewski	ADJ
dti-1318	105	5	,	,	PUNCT
dti-1318	105	6	2005	2005	NUM
dti-1318	105	7	)	)	PUNCT
dti-1318	105	8	(	(	PUNCT
dti-1318	105	9	bannwarth	bannwarth	NOUN
dti-1318	105	10	et	et	PROPN
dti-1318	105	11	al	al	PROPN
dti-1318	105	12	.	.	PROPN
dti-1318	105	13	2006	2006	NUM
dti-1318	105	14	)	)	PUNCT
dti-1318	105	15	β	β	X
dti-1318	105	16	-	-	ADJ
dti-1318	105	17	sheet	sheet	NOUN
dti-1318	105	18	peptide	peptide	NOUN
dti-1318	105	19	/	/	SYM
dti-1318	105	20	peptidomimetic	peptidomimetic	NOUN
dti-1318	105	21	pr	pr	NOUN
dti-1318	105	22	interface	interface	NOUN
dti-1318	105	23	derived	derive	VERB
dti-1318	105	24	(	(	PUNCT
dti-1318	105	25	song	song	NOUN
dti-1318	105	26	et	et	PROPN
dti-1318	105	27	al	al	PROPN
dti-1318	105	28	.	.	PROPN
dti-1318	105	29	2001	2001	NUM
dti-1318	105	30	)	)	PUNCT
dti-1318	105	31	peptidomimetics	peptidomimetic	NOUN
dti-1318	105	32	pqitl	pqitl	NOUN
dti-1318	105	33	-	-	PUNCT
dti-1318	105	34	rkkrrqrrrppqv	rkkrrqrrrppqv	NOUN
dti-1318	105	35	-	-	PUNCT
dti-1318	105	36	sfnfpr	sfnfpr	NOUN
dti-1318	105	37	c	c	NOUN
dti-1318	105	38	-	-	PUNCT
dti-1318	105	39	terminal	terminal	ADJ
dti-1318	105	40	fusion	fusion	NOUN
dti-1318	105	41	(	(	PUNCT
dti-1318	105	42	davis	davis	PROPN
dti-1318	105	43	et	et	PROPN
dti-1318	105	44	al	al	PROPN
dti-1318	105	45	.	.	PROPN
dti-1318	105	46	2006	2006	NUM
dti-1318	105	47	)	)	PUNCT
dti-1318	105	48	c	c	X
dti-1318	105	49	/	/	SYM
dti-1318	105	50	atln	atln	ADJ
dti-1318	105	51	(	(	PUNCT
dti-1318	105	52	p27	p27	NOUN
dti-1318	105	53	/	/	SYM
dti-1318	105	54	p27a	p27a	NOUN
dti-1318	105	55	)	)	PUNCT
dti-1318	105	56	peptide	peptide	ADJ
dti-1318	105	57	bocfψ[ch2nh]fef	bocfψ[ch2nh]fef	PROPN
dti-1318	105	58	-	-	PUNCT
dti-1318	105	59	nh	nh	PROPN
dti-1318	105	60	-	-	PUNCT
dti-1318	105	61	ch2	ch2	NOUN
dti-1318	105	62	-	-	PUNCT
dti-1318	105	63	colinked	colinke	VERB
dti-1318	105	64	pr	pr	NOUN
dti-1318	105	65	c	c	NOUN
dti-1318	105	66	-	-	PUNCT
dti-1318	105	67	terminal	terminal	ADJ
dti-1318	105	68	(	(	PUNCT
dti-1318	105	69	uhlikova	uhlikova	PROPN
dti-1318	105	70	et	et	PROPN
dti-1318	105	71	al	al	PROPN
dti-1318	105	72	.	.	PROPN
dti-1318	105	73	1996	1996	NUM
dti-1318	105	74	)	)	PUNCT
dti-1318	105	75	tlnf	tlnf	PROPN
dti-1318	105	76	-	-	PROPN
dti-1318	105	77	oh	oh	INTJ
dti-1318	105	78	tetrapeptide	tetrapeptide	ADJ
dti-1318	105	79	—	—	PUNCT
dti-1318	105	80	active	active	ADJ
dti-1318	105	81	site	site	NOUN
dti-1318	105	82	(	(	PUNCT
dti-1318	105	83	skalova	skalova	VERB
dti-1318	105	84	et	et	PROPN
dti-1318	105	85	al	al	PROPN
dti-1318	105	86	.	.	PROPN
dti-1318	105	87	2003	2003	NUM
dti-1318	105	88	)	)	PUNCT
dti-1318	105	89	inhibitor	inhibitor	NOUN
dti-1318	105	90	pentaester	pentaester	NOUN
dti-1318	105	91	13e	13e	PUNCT
dti-1318	105	92	didemnaketal	didemnaketal	VERB
dti-1318	105	93	a	a	DET
dti-1318	105	94	analogue	analogue	NOUN
dti-1318	105	95	(	(	PUNCT
dti-1318	105	96	fan	fan	NOUN
dti-1318	105	97	et	et	PROPN
dti-1318	105	98	al	al	PROPN
dti-1318	105	99	.	.	PROPN
dti-1318	105	100	1998	1998	NUM
dti-1318	105	101	)	)	PUNCT
dti-1318	105	102	ursolic	ursolic	ADJ
dti-1318	105	103	acid	acid	NOUN
dti-1318	105	104	triterpene	triterpene	NOUN
dti-1318	105	105	(	(	PUNCT
dti-1318	105	106	quere	quere	X
dti-1318	105	107	et	et	PROPN
dti-1318	105	108	al	al	PROPN
dti-1318	105	109	.	.	PROPN
dti-1318	105	110	1996	1996	NUM
dti-1318	105	111	)	)	PUNCT
dti-1318	105	112	nhgrnlltqi	nhgrnlltqi	NOUN
dti-1318	105	113	(	(	PUNCT
dti-1318	105	114	s8	s8	PROPN
dti-1318	105	115	)	)	PUNCT
dti-1318	105	116	pr	pr	NOUN
dti-1318	105	117	les	les	PROPN
dti-1318	105	118	peptide	peptide	NOUN
dti-1318	105	119	(	(	PUNCT
dti-1318	105	120	broglia	broglia	PROPN
dti-1318	105	121	et	et	PROPN
dti-1318	105	122	al	al	PROPN
dti-1318	105	123	.	.	PROPN
dti-1318	105	124	2005	2005	NUM
dti-1318	105	125	)	)	PUNCT
dti-1318	105	126	(	(	PUNCT
dti-1318	105	127	broglia	broglia	PROPN
dti-1318	105	128	et	et	PROPN
dti-1318	105	129	al	al	PROPN
dti-1318	105	130	.	.	PROPN
dti-1318	105	131	2006	2006	NUM
dti-1318	105	132	)	)	PUNCT
dti-1318	105	133	ivqvdaeg	ivqvdaeg	NOUN
dti-1318	105	134	(	(	PUNCT
dti-1318	105	135	p51	p51	PROPN
dti-1318	105	136	)	)	PUNCT
dti-1318	105	137	random	random	ADJ
dti-1318	105	138	peptide	peptide	NOUN
dti-1318	105	139	(	(	PUNCT
dti-1318	105	140	park	park	NOUN
dti-1318	105	141	and	and	CCONJ
dti-1318	105	142	raines	raine	NOUN
dti-1318	105	143	,	,	PUNCT
dti-1318	105	144	2000	2000	NUM
dti-1318	105	145	)	)	PUNCT
dti-1318	105	146	.	.	PUNCT
dti-1318	106	1	vpr-(spacer)-tlnf	vpr-(spacer)-tlnf	PROPN
dti-1318	106	2	-	-	PUNCT
dti-1318	106	3	oh	oh	NOUN
dti-1318	106	4	vpr	vpr	NOUN
dti-1318	106	5	,	,	PUNCT
dti-1318	106	6	pr	pr	ADP
dti-1318	106	7	c	c	NOUN
dti-1318	106	8	-	-	PUNCT
dti-1318	106	9	terminal	terminal	ADJ
dti-1318	106	10	fusion	fusion	NOUN
dti-1318	106	11	peptide	peptide	NOUN
dti-1318	106	12	(	(	PUNCT
dti-1318	106	13	cartas	carta	NOUN
dti-1318	106	14	et	et	PROPN
dti-1318	106	15	al	al	PROPN
dti-1318	106	16	.	.	PROPN
dti-1318	106	17	2001	2001	NUM
dti-1318	106	18	)	)	PUNCT
dti-1318	106	19	.	.	PUNCT
dti-1318	107	1	maturation	maturation	NOUN
dti-1318	107	2	—	—	PUNCT
dti-1318	107	3	rt	rt	NUM
dti-1318	107	4	dimerisation	dimerisation	NOUN
dti-1318	108	1	[	[	X
dti-1318	108	2	2′,5′-bis	2′,5′-bis	ADJ
dti-1318	108	3	-	-	ADJ
dti-1318	108	4	o-(tert	o-(tert	ADJ
dti-1318	108	5	-	-	PUNCT
dti-1318	108	6	butyldimethylsilyl)-βsmall	butyldimethylsilyl)-βsmall	NOUN
dti-1318	108	7	molecule	molecule	NOUN
dti-1318	108	8	(	(	PUNCT
dti-1318	108	9	sluis	sluis	NOUN
dti-1318	108	10	-	-	PUNCT
dti-1318	108	11	cremer	cremer	NOUN
dti-1318	108	12	et	et	PROPN
dti-1318	108	13	al	al	PROPN
dti-1318	108	14	.	.	PROPN
dti-1318	108	15	2000	2000	NUM
dti-1318	108	16	)	)	PUNCT
dti-1318	108	17	d	d	X
dti-1318	108	18	-	-	PUNCT
dti-1318	108	19	ribofuranosyl]-3′-spiro-5″-(4″-amino	ribofuranosyl]-3′-spiro-5″-(4″-amino	NOUN
dti-1318	108	20	(	(	PUNCT
dti-1318	108	21	rodriguez	rodriguez	NOUN
dti-1318	108	22	-	-	PUNCT
dti-1318	108	23	barrios	barrio	NOUN
dti-1318	108	24	et	et	PROPN
dti-1318	108	25	al	al	PROPN
dti-1318	108	26	.	.	PROPN
dti-1318	108	27	1′,2″-oxathiole-2″,2″-dioxide	1′,2″-oxathiole-2″,2″-dioxide	NUM
dti-1318	108	28	)	)	PUNCT
dti-1318	108	29	2001	2001	NUM
dti-1318	108	30	)	)	PUNCT
dti-1318	108	31	thymine	thymine	NOUN
dti-1318	108	32	(	(	PUNCT
dti-1318	108	33	tsao	tsao	PROPN
dti-1318	108	34	-	-	PUNCT
dti-1318	108	35	t	t	PROPN
dti-1318	108	36	)	)	PUNCT
dti-1318	108	37	n-(4	n-(4	ADV
dti-1318	108	38	-	-	PUNCT
dti-1318	108	39	tert	tert	NOUN
dti-1318	108	40	-	-	PUNCT
dti-1318	108	41	butylbenzoyl)-2	butylbenzoyl)-2	NOUN
dti-1318	108	42	-	-	PUNCT
dti-1318	108	43	hydroxy-1small	hydroxy-1small	NOUN
dti-1318	108	44	molecule	molecule	NOUN
dti-1318	108	45	(	(	PUNCT
dti-1318	108	46	arion	arion	PROPN
dti-1318	108	47	et	et	PROPN
dti-1318	108	48	al	al	PROPN
dti-1318	108	49	.	.	PROPN
dti-1318	108	50	2002	2002	NUM
dti-1318	108	51	)	)	PUNCT
dti-1318	108	52	naphthaldehyde	naphthaldehyde	NOUN
dti-1318	108	53	hydrazone	hydrazone	NOUN
dti-1318	108	54	)	)	PUNCT
dti-1318	108	55	(	(	PUNCT
dti-1318	108	56	bbnh	bbnh	NOUN
dti-1318	108	57	)	)	PUNCT
dti-1318	108	58	(	(	PUNCT
dti-1318	108	59	sluis	sluis	NOUN
dti-1318	108	60	-	-	PUNCT
dti-1318	108	61	cremer	cremer	NOUN
dti-1318	108	62	and	and	CCONJ
dti-1318	108	63	tachedjian	tachedjian	NOUN
dti-1318	108	64	,	,	PUNCT
dti-1318	108	65	2002	2002	NUM
dti-1318	108	66	)	)	PUNCT
dti-1318	108	67	(	(	PUNCT
dti-1318	108	68	himmel	himmel	X
dti-1318	108	69	et	et	PROPN
dti-1318	108	70	al	al	PROPN
dti-1318	108	71	.	.	PROPN
dti-1318	108	72	)	)	PUNCT
dti-1318	109	1	ketwetwwte	ketwetwwte	PROPN
dti-1318	109	2	(	(	PUNCT
dti-1318	109	3	pep-7	pep-7	NOUN
dti-1318	109	4	)	)	PUNCT
dti-1318	109	5	rt	rt	NOUN
dti-1318	109	6	connection	connection	NOUN
dti-1318	109	7	subdomain	subdomain	NOUN
dti-1318	109	8	peptide	peptide	NOUN
dti-1318	109	9	(	(	PUNCT
dti-1318	109	10	morris	morris	PROPN
dti-1318	109	11	et	et	PROPN
dti-1318	109	12	al	al	PROPN
dti-1318	109	13	.	.	PROPN
dti-1318	109	14	1999	1999	NUM
dti-1318	109	15	)	)	PUNCT
dti-1318	109	16	(	(	PUNCT
dti-1318	109	17	depollier	depollier	NOUN
dti-1318	109	18	et	et	PROPN
dti-1318	109	19	al	al	PROPN
dti-1318	109	20	.	.	PROPN
dti-1318	109	21	2005	2005	NUM
dti-1318	109	22	)	)	PUNCT
dti-1318	109	23	tlmalelkgklllaglapsaflplsfp	tlmalelkgklllaglapsaflplsfp	ADV
dti-1318	109	24	designed	design	VERB
dti-1318	109	25	peptide	peptide	NOUN
dti-1318	109	26	targeting	target	VERB
dti-1318	109	27	(	(	PUNCT
dti-1318	109	28	campbell	campbell	PROPN
dti-1318	109	29	et	et	PROPN
dti-1318	109	30	al	al	PROPN
dti-1318	109	31	.	.	PROPN
dti-1318	109	32	2002	2002	NUM
dti-1318	109	33	)	)	PUNCT
dti-1318	109	34	egl	egl	NOUN
dti-1318	109	35	(	(	PUNCT
dti-1318	109	36	tlma2993	tlma2993	PROPN
dti-1318	109	37	)	)	PUNCT
dti-1318	109	38	rt	rt	PROPN
dti-1318	109	39	connection	connection	NOUN
dti-1318	109	40	subdomain	subdomain	NOUN
dti-1318	109	41	(	(	PUNCT
dti-1318	109	42	hosokawa	hosokawa	NOUN
dti-1318	109	43	et	et	PROPN
dti-1318	109	44	al	al	PROPN
dti-1318	109	45	.	.	PROPN
dti-1318	109	46	2004	2004	NUM
dti-1318	109	47	)	)	PUNCT
dti-1318	109	48	maturation	maturation	NOUN
dti-1318	109	49	—	—	PUNCT
dti-1318	109	50	in	in	ADP
dti-1318	109	51	dimerisation	dimerisation	NOUN
dti-1318	109	52	ini	ini	PROPN
dti-1318	109	53	1	1	NUM
dti-1318	109	54	host	host	NOUN
dti-1318	109	55	cell	cell	NOUN
dti-1318	109	56	factor	factor	NOUN
dti-1318	109	57	(	(	PUNCT
dti-1318	109	58	yung	yung	NOUN
dti-1318	109	59	et	et	PROPN
dti-1318	109	60	al	al	PROPN
dti-1318	109	61	.	.	PROPN
dti-1318	109	62	2001	2001	NUM
dti-1318	109	63	)	)	PUNCT
dti-1318	109	64	(	(	PUNCT
dti-1318	109	65	sorin	sorin	NOUN
dti-1318	109	66	et	et	PROPN
dti-1318	109	67	al	al	PROPN
dti-1318	109	68	.	.	PROPN
dti-1318	109	69	2006	2006	NUM
dti-1318	109	70	)	)	PUNCT
dti-1318	109	71	(	(	PUNCT
dti-1318	109	72	ariumi	ariumi	NOUN
dti-1318	109	73	et	et	PROPN
dti-1318	109	74	al	al	PROPN
dti-1318	109	75	.	.	PROPN
dti-1318	109	76	2006	2006	NUM
dti-1318	109	77	)	)	PUNCT
dti-1318	109	78	(	(	PUNCT
dti-1318	109	79	kalpana	kalpana	PROPN
dti-1318	109	80	et	et	PROPN
dti-1318	109	81	al	al	PROPN
dti-1318	109	82	.	.	PROPN
dti-1318	109	83	1994	1994	NUM
dti-1318	109	84	)	)	PUNCT
dti-1318	109	85	budding	bud	VERB
dti-1318	109	86	and	and	CCONJ
dti-1318	109	87	egress	egress	NOUN
dti-1318	109	88	5-(n	5-(n	NUM
dti-1318	109	89	,	,	PUNCT
dti-1318	109	90	n	n	CCONJ
dti-1318	109	91	-	-	PUNCT
dti-1318	109	92	hexamethylene)amiloride	hexamethylene)amiloride	PROPN
dti-1318	109	93	(	(	PUNCT
dti-1318	109	94	hma	hma	NOUN
dti-1318	109	95	)	)	PUNCT
dti-1318	109	96	amiloride	amiloride	ADJ
dti-1318	109	97	analogue	analogue	NOUN
dti-1318	109	98	(	(	PUNCT
dti-1318	109	99	ewart	ewart	NOUN
dti-1318	109	100	et	et	PROPN
dti-1318	109	101	al	al	PROPN
dti-1318	109	102	.	.	PROPN
dti-1318	109	103	2002	2002	NUM
dti-1318	109	104	)	)	PUNCT
dti-1318	109	105	5-(n	5-(n	NUM
dti-1318	109	106	,	,	PUNCT
dti-1318	109	107	n	n	CCONJ
dti-1318	109	108	-	-	PUNCT
dti-1318	109	109	dimethyl)amiloride	dimethyl)amiloride	NOUN
dti-1318	109	110	(	(	PUNCT
dti-1318	109	111	dma	dma	PROPN
dti-1318	109	112	)	)	PUNCT
dti-1318	109	113	(	(	PUNCT
dti-1318	109	114	ewart	ewart	NOUN
dti-1318	109	115	et	et	PROPN
dti-1318	109	116	al	al	PROPN
dti-1318	109	117	.	.	PROPN
dti-1318	109	118	2004	2004	NUM
dti-1318	109	119	)	)	PUNCT
dti-1318	109	120	vpu	vpu	ADP
dti-1318	109	121	binding	bind	VERB
dti-1318	109	122	protein	protein	NOUN
dti-1318	109	123	(	(	PUNCT
dti-1318	109	124	ubp	ubp	NOUN
dti-1318	109	125	)	)	PUNCT
dti-1318	109	126	host	host	NOUN
dti-1318	109	127	cell	cell	NOUN
dti-1318	109	128	factor	factor	NOUN
dti-1318	109	129	(	(	PUNCT
dti-1318	109	130	callahan	callahan	PROPN
dti-1318	109	131	et	et	PROPN
dti-1318	109	132	al	al	PROPN
dti-1318	109	133	.	.	PROPN
dti-1318	109	134	1998	1998	NUM
dti-1318	109	135	)	)	PUNCT
dti-1318	109	136	(	(	PUNCT
dti-1318	109	137	handley	handley	PROPN
dti-1318	109	138	et	et	PROPN
dti-1318	109	139	al	al	PROPN
dti-1318	109	140	.	.	PROPN
dti-1318	109	141	2001	2001	NUM
dti-1318	109	142	)	)	PUNCT
dti-1318	110	1	(	(	PUNCT
dti-1318	110	2	harila	harila	NOUN
dti-1318	110	3	et	et	PROPN
dti-1318	110	4	al	al	PROPN
dti-1318	110	5	.	.	PROPN
dti-1318	110	6	2006	2006	NUM
dti-1318	110	7	)	)	PUNCT
dti-1318	110	8	(	(	PUNCT
dti-1318	110	9	neil	neil	PROPN
dti-1318	110	10	et	et	PROPN
dti-1318	110	11	al	al	PROPN
dti-1318	110	12	.	.	PROPN
dti-1318	110	13	2006	2006	NUM
dti-1318	110	14	)	)	PUNCT
dti-1318	111	1	tsg101	tsg101	NOUN
dti-1318	111	2	host	host	NOUN
dti-1318	111	3	cell	cell	NOUN
dti-1318	111	4	factor	factor	NOUN
dti-1318	111	5	(	(	PUNCT
dti-1318	111	6	garrus	garrus	PROPN
dti-1318	111	7	et	et	PROPN
dti-1318	111	8	al	al	PROPN
dti-1318	111	9	.	.	PROPN
dti-1318	111	10	2001	2001	NUM
dti-1318	111	11	)	)	PUNCT
dti-1318	112	1	(	(	PUNCT
dti-1318	112	2	demirov	demirov	VERB
dti-1318	112	3	et	et	PROPN
dti-1318	112	4	al	al	PROPN
dti-1318	112	5	.	.	PROPN
dti-1318	112	6	2002	2002	NUM
dti-1318	112	7	)	)	PUNCT
dti-1318	112	8	(	(	PUNCT
dti-1318	112	9	goila	goila	NOUN
dti-1318	112	10	-	-	PUNCT
dti-1318	112	11	gaur	gaur	NOUN
dti-1318	112	12	et	et	PROPN
dti-1318	112	13	al	al	PROPN
dti-1318	112	14	.	.	PROPN
dti-1318	112	15	2003	2003	NUM
dti-1318	112	16	)	)	PUNCT
dti-1318	112	17	zlll	zlll	ADV
dti-1318	112	18	/	/	SYM
dti-1318	112	19	mg-132	mg-132	NOUN
dti-1318	112	20	lactocystin	lactocystin	ADJ
dti-1318	112	21	proteosome	proteosome	NOUN
dti-1318	112	22	inhibitor	inhibitor	NOUN
dti-1318	112	23	(	(	PUNCT
dti-1318	112	24	schubert	schubert	PROPN
dti-1318	112	25	et	et	PROPN
dti-1318	112	26	al	al	PROPN
dti-1318	112	27	.	.	PROPN
dti-1318	112	28	2000	2000	NUM
dti-1318	112	29	)	)	PUNCT
dti-1318	112	30	(	(	PUNCT
dti-1318	112	31	ott	ott	PROPN
dti-1318	112	32	et	et	PROPN
dti-1318	112	33	al	al	PROPN
dti-1318	112	34	.	.	PROPN
dti-1318	112	35	2003	2003	NUM
dti-1318	112	36	)	)	PUNCT
dti-1318	112	37	abbreviations	abbreviation	NOUN
dti-1318	112	38	:	:	PUNCT
dti-1318	112	39	ac	ac	ADJ
dti-1318	112	40	:	:	PUNCT
dti-1318	112	41	acetylation	acetylation	NOUN
dti-1318	112	42	;	;	PUNCT
dti-1318	112	43	pam	pam	NOUN
dti-1318	112	44	:	:	PUNCT
dti-1318	112	45	palmitoyl	palmitoyl	ADJ
dti-1318	112	46	;	;	PUNCT
dti-1318	112	47	apam	apam	VERB
dti-1318	112	48	:	:	PUNCT
dti-1318	112	49	2	2	NUM
dti-1318	112	50	-	-	PUNCT
dti-1318	112	51	aminopalmitic	aminopalmitic	ADJ
dti-1318	112	52	acid	acid	NOUN
dti-1318	112	53	table	table	NOUN
dti-1318	112	54	1	1	NUM
dti-1318	112	55	.	.	PUNCT
dti-1318	112	56	(	(	PUNCT
dti-1318	112	57	continued	continued	ADJ
dti-1318	112	58	)	)	PUNCT
dti-1318	112	59	inhibitor	inhibitor	NOUN
dti-1318	112	60	description	description	NOUN
dti-1318	112	61	reference	reference	NOUN
dti-1318	112	62	165	165	NUM
dti-1318	112	63	targeting	target	VERB
dti-1318	112	64	the	the	DET
dti-1318	112	65	late	late	ADJ
dti-1318	112	66	stages	stage	NOUN
dti-1318	112	67	of	of	ADP
dti-1318	112	68	hiv-1	hiv-1	X
dti-1318	112	69	replication	replication	NOUN
dti-1318	112	70	drug	drug	NOUN
dti-1318	112	71	target	target	NOUN
dti-1318	112	72	insights	insight	NOUN
dti-1318	112	73	2007	2007	NUM
dti-1318	112	74	:	:	PUNCT
dti-1318	112	75	2	2	NUM
dti-1318	112	76	gag	gag	NOUN
dti-1318	112	77	-	-	PUNCT
dti-1318	112	78	pol	pol	NOUN
dti-1318	112	79	traffi	traffi	NOUN
dti-1318	112	80	cking	cking	ADJ
dti-1318	112	81	(	(	PUNCT
dti-1318	112	82	bryant	bryant	PROPN
dti-1318	112	83	et	et	PROPN
dti-1318	112	84	al	al	PROPN
dti-1318	112	85	.	.	PROPN
dti-1318	112	86	1991	1991	NUM
dti-1318	112	87	)	)	PUNCT
dti-1318	112	88	.	.	PUNCT
dti-1318	113	1	in	in	ADP
dti-1318	113	2	an	an	DET
dti-1318	113	3	acutely	acutely	ADV
dti-1318	113	4	infected	infect	VERB
dti-1318	113	5	t	t	PROPN
dti-1318	113	6	-	-	PUNCT
dti-1318	113	7	cell	cell	NOUN
dti-1318	113	8	line	line	NOUN
dti-1318	113	9	13	13	NUM
dti-1318	113	10	-	-	PUNCT
dti-1318	113	11	oxamyr	oxamyr	NOUN
dti-1318	113	12	reduces	reduce	VERB
dti-1318	113	13	hiv-1	hiv-1	PART
dti-1318	113	14	replication	replication	NOUN
dti-1318	113	15	in	in	ADP
dti-1318	113	16	the	the	DET
dti-1318	113	17	40–80	40–80	PROPN
dti-1318	113	18	µm	µm	NUM
dti-1318	113	19	range	range	NOUN
dti-1318	113	20	(	(	PUNCT
dti-1318	113	21	bryant	bryant	PROPN
dti-1318	113	22	et	et	PROPN
dti-1318	113	23	al	al	PROPN
dti-1318	113	24	.	.	PROPN
dti-1318	113	25	1989	1989	NUM
dti-1318	113	26	)	)	PUNCT
dti-1318	113	27	.	.	PUNCT
dti-1318	114	1	13	13	NUM
dti-1318	114	2	-	-	PUNCT
dti-1318	114	3	oxamyr	oxamyr	NOUN
dti-1318	114	4	also	also	ADV
dti-1318	114	5	inhibits	inhibit	VERB
dti-1318	114	6	viral	viral	ADJ
dti-1318	114	7	production	production	NOUN
dti-1318	114	8	in	in	ADP
dti-1318	114	9	chronically	chronically	ADV
dti-1318	114	10	infected	infect	VERB
dti-1318	114	11	h9	h9	NOUN
dti-1318	114	12	/	/	SYM
dti-1318	114	13	iiib	iiib	NOUN
dti-1318	114	14	cells	cell	NOUN
dti-1318	114	15	,	,	PUNCT
dti-1318	114	16	which	which	PRON
dti-1318	114	17	is	be	AUX
dti-1318	114	18	consistent	consistent	ADJ
dti-1318	114	19	for	for	ADP
dti-1318	114	20	an	an	DET
dti-1318	114	21	inhibitor	inhibitor	NOUN
dti-1318	114	22	that	that	PRON
dti-1318	114	23	targets	target	VERB
dti-1318	114	24	the	the	DET
dti-1318	114	25	late	late	ADJ
dti-1318	114	26	stage	stage	NOUN
dti-1318	114	27	of	of	ADP
dti-1318	114	28	hiv-1	hiv-1	X
dti-1318	114	29	replication	replication	NOUN
dti-1318	114	30	(	(	PUNCT
dti-1318	114	31	bryant	bryant	PROPN
dti-1318	114	32	et	et	PROPN
dti-1318	114	33	al	al	PROPN
dti-1318	114	34	.	.	PROPN
dti-1318	114	35	1991	1991	NUM
dti-1318	114	36	)	)	PUNCT
dti-1318	114	37	.	.	PUNCT
dti-1318	115	1	13	13	NUM
dti-1318	115	2	-	-	PUNCT
dti-1318	115	3	oxamyr	oxamyr	NOUN
dti-1318	115	4	exhibits	exhibit	VERB
dti-1318	115	5	a	a	DET
dti-1318	115	6	synergistic	synergistic	ADJ
dti-1318	115	7	antihiv-1	antihiv-1	NUM
dti-1318	115	8	effect	effect	NOUN
dti-1318	115	9	with	with	ADP
dti-1318	115	10	azt	azt	PROPN
dti-1318	115	11	suggesting	suggest	VERB
dti-1318	115	12	its	its	PRON
dti-1318	115	13	potential	potential	NOUN
dti-1318	115	14	for	for	ADP
dti-1318	115	15	use	use	NOUN
dti-1318	115	16	in	in	ADP
dti-1318	115	17	combination	combination	NOUN
dti-1318	115	18	therapy	therapy	NOUN
dti-1318	115	19	(	(	PUNCT
dti-1318	115	20	bryant	bryant	PROPN
dti-1318	115	21	et	et	PROPN
dti-1318	115	22	al	al	PROPN
dti-1318	115	23	.	.	PROPN
dti-1318	115	24	1991	1991	NUM
dti-1318	115	25	)	)	PUNCT
dti-1318	115	26	.	.	PUNCT
dti-1318	116	1	the	the	DET
dti-1318	116	2	therapeutic	therapeutic	PROPN
dti-1318	116	3	effi	effi	PROPN
dti-1318	116	4	cacy	cacy	NOUN
dti-1318	116	5	of	of	ADP
dti-1318	116	6	13	13	NUM
dti-1318	116	7	-	-	PUNCT
dti-1318	116	8	oxamyr	oxamyr	NOUN
dti-1318	116	9	can	can	AUX
dti-1318	116	10	be	be	AUX
dti-1318	116	11	further	far	ADV
dti-1318	116	12	enhanced	enhance	VERB
dti-1318	116	13	by	by	ADP
dti-1318	116	14	conjugation	conjugation	NOUN
dti-1318	116	15	with	with	ADP
dti-1318	116	16	glycerophospholipid	glycerophospholipid	NOUN
dti-1318	116	17	l-∝-phosphatidylethanolamine	l-∝-phosphatidylethanolamine	PROPN
dti-1318	116	18	(	(	PUNCT
dti-1318	116	19	pidgeon	pidgeon	NOUN
dti-1318	116	20	et	et	PROPN
dti-1318	116	21	al	al	PROPN
dti-1318	116	22	.	.	PROPN
dti-1318	116	23	1993	1993	NUM
dti-1318	116	24	)	)	PUNCT
dti-1318	116	25	.	.	PUNCT
dti-1318	117	1	the	the	DET
dti-1318	117	2	selectivity	selectivity	NOUN
dti-1318	117	3	of	of	ADP
dti-1318	117	4	these	these	DET
dti-1318	117	5	heteroatom	heteroatom	NOUN
dti-1318	117	6	analogs	analog	NOUN
dti-1318	117	7	for	for	ADP
dti-1318	117	8	the	the	DET
dti-1318	117	9	target	target	NOUN
dti-1318	117	10	protein	protein	NOUN
dti-1318	117	11	is	be	AUX
dti-1318	117	12	dependent	dependent	ADJ
dti-1318	117	13	on	on	ADP
dti-1318	117	14	the	the	DET
dti-1318	117	15	position	position	NOUN
dti-1318	117	16	of	of	ADP
dti-1318	117	17	the	the	DET
dti-1318	117	18	substituted	substitute	VERB
dti-1318	117	19	heteroatom	heteroatom	NOUN
dti-1318	117	20	,	,	PUNCT
dti-1318	117	21	thus	thus	ADV
dti-1318	117	22	they	they	PRON
dti-1318	117	23	can	can	AUX
dti-1318	117	24	be	be	AUX
dti-1318	117	25	exploited	exploit	VERB
dti-1318	117	26	as	as	ADP
dti-1318	117	27	a	a	DET
dti-1318	117	28	therapeutic	therapeutic	ADJ
dti-1318	117	29	antiretroviral	antiretroviral	ADJ
dti-1318	117	30	strategy	strategy	NOUN
dti-1318	117	31	.	.	PUNCT
dti-1318	118	1	nevertheless	nevertheless	ADV
dti-1318	118	2	,	,	PUNCT
dti-1318	118	3	heteroatom	heteroatom	NOUN
dti-1318	118	4	-	-	PUNCT
dti-1318	118	5	substituted	substitute	VERB
dti-1318	118	6	myristic	myristic	ADJ
dti-1318	118	7	acid	acid	NOUN
dti-1318	118	8	analogs	analog	NOUN
dti-1318	118	9	are	be	AUX
dti-1318	118	10	still	still	ADV
dti-1318	118	11	expected	expect	VERB
dti-1318	118	12	to	to	PART
dti-1318	118	13	adversely	adversely	ADV
dti-1318	118	14	affect	affect	VERB
dti-1318	118	15	a	a	DET
dti-1318	118	16	substantial	substantial	ADJ
dti-1318	118	17	range	range	NOUN
dti-1318	118	18	of	of	ADP
dti-1318	118	19	cellular	cellular	ADJ
dti-1318	118	20	processes	process	NOUN
dti-1318	118	21	that	that	PRON
dti-1318	118	22	depend	depend	VERB
dti-1318	118	23	on	on	ADP
dti-1318	118	24	protein	protein	NOUN
dti-1318	118	25	n	n	NOUN
dti-1318	118	26	-	-	PUNCT
dti-1318	118	27	myristoylation	myristoylation	NOUN
dti-1318	118	28	(	(	PUNCT
dti-1318	118	29	lindwasser	lindwasser	ADJ
dti-1318	118	30	and	and	CCONJ
dti-1318	118	31	resh	resh	NOUN
dti-1318	118	32	,	,	PUNCT
dti-1318	118	33	2002	2002	NUM
dti-1318	118	34	)	)	PUNCT
dti-1318	118	35	.	.	PUNCT
dti-1318	119	1	an	an	DET
dti-1318	119	2	alternative	alternative	ADJ
dti-1318	119	3	strategy	strategy	NOUN
dti-1318	119	4	for	for	ADP
dti-1318	119	5	targeting	target	VERB
dti-1318	119	6	gag	gag	NOUN
dti-1318	119	7	myristoylation	myristoylation	NOUN
dti-1318	119	8	is	be	AUX
dti-1318	119	9	the	the	DET
dti-1318	119	10	exogenous	exogenous	ADJ
dti-1318	119	11	treatment	treatment	NOUN
dti-1318	119	12	of	of	ADP
dti-1318	119	13	cells	cell	NOUN
dti-1318	119	14	with	with	ADP
dti-1318	119	15	unsaturated	unsaturated	ADJ
dti-1318	119	16	14	14	NUM
dti-1318	119	17	-	-	PUNCT
dti-1318	119	18	carbon	carbon	NOUN
dti-1318	119	19	fatty	fatty	NOUN
dti-1318	119	20	acids	acid	NOUN
dti-1318	119	21	including	include	VERB
dti-1318	119	22	5	5	NUM
dti-1318	119	23	-	-	PUNCT
dti-1318	119	24	cistetradecenoic	cistetradecenoic	ADJ
dti-1318	119	25	acid	acid	NOUN
dti-1318	119	26	(	(	PUNCT
dti-1318	119	27	14:1n-9	14:1n-9	PROPN
dti-1318	119	28	,	,	PUNCT
dti-1318	119	29	physeteric	physeteric	ADJ
dti-1318	119	30	acid	acid	NOUN
dti-1318	119	31	)	)	PUNCT
dti-1318	119	32	and	and	CCONJ
dti-1318	119	33	5	5	NUM
dti-1318	119	34	-	-	PUNCT
dti-1318	119	35	cis,8	cis,8	NOUN
dti-1318	119	36	-	-	PUNCT
dti-1318	119	37	cis	cis	NOUN
dti-1318	119	38	-	-	ADJ
dti-1318	119	39	tetradecadienoic	tetradecadienoic	ADJ
dti-1318	119	40	acid	acid	NOUN
dti-1318	119	41	(	(	PUNCT
dti-1318	119	42	14:2n-6	14:2n-6	PROPN
dti-1318	119	43	,	,	PUNCT
dti-1318	119	44	goshuyic	goshuyic	ADJ
dti-1318	119	45	acid	acid	NOUN
dti-1318	119	46	)	)	PUNCT
dti-1318	119	47	(	(	PUNCT
dti-1318	119	48	lindwasser	lindwasser	NOUN
dti-1318	119	49	and	and	CCONJ
dti-1318	119	50	resh	resh	NOUN
dti-1318	119	51	,	,	PUNCT
dti-1318	119	52	2002	2002	NUM
dti-1318	119	53	)	)	PUNCT
dti-1318	119	54	.	.	PUNCT
dti-1318	120	1	as	as	SCONJ
dti-1318	120	2	lipid	lipid	NOUN
dti-1318	120	3	rafts	raft	NOUN
dti-1318	120	4	have	have	VERB
dti-1318	120	5	preference	preference	NOUN
dti-1318	120	6	for	for	ADP
dti-1318	120	7	saturated	saturate	VERB
dti-1318	120	8	fatty	fatty	NOUN
dti-1318	120	9	acids	acid	NOUN
dti-1318	120	10	,	,	PUNCT
dti-1318	120	11	treatment	treatment	NOUN
dti-1318	120	12	with	with	ADP
dti-1318	120	13	unsaturated	unsaturate	VERB
dti-1318	120	14	analogs	analog	NOUN
dti-1318	120	15	interferes	interfere	VERB
dti-1318	120	16	with	with	ADP
dti-1318	120	17	membrane	membrane	NOUN
dti-1318	120	18	targeting	targeting	NOUN
dti-1318	120	19	of	of	ADP
dti-1318	120	20	gag	gag	NOUN
dti-1318	120	21	and	and	CCONJ
dti-1318	120	22	consequentially	consequentially	ADV
dti-1318	120	23	viral	viral	ADJ
dti-1318	120	24	assembly	assembly	NOUN
dti-1318	120	25	and	and	CCONJ
dti-1318	120	26	production	production	NOUN
dti-1318	120	27	(	(	PUNCT
dti-1318	120	28	lindwasser	lindwasser	ADJ
dti-1318	120	29	and	and	CCONJ
dti-1318	120	30	resh	resh	NOUN
dti-1318	120	31	,	,	PUNCT
dti-1318	120	32	2002	2002	NUM
dti-1318	120	33	)	)	PUNCT
dti-1318	120	34	.	.	PUNCT
dti-1318	121	1	these	these	DET
dti-1318	121	2	inhibitors	inhibitor	NOUN
dti-1318	121	3	also	also	ADV
dti-1318	121	4	interfere	interfere	VERB
dti-1318	121	5	with	with	ADP
dti-1318	121	6	certain	certain	ADJ
dti-1318	121	7	srckinase	srckinase	NOUN
dti-1318	121	8	mediated	mediate	VERB
dti-1318	121	9	cellular	cellular	ADJ
dti-1318	121	10	pathways	pathway	NOUN
dti-1318	121	11	,	,	PUNCT
dti-1318	121	12	although	although	SCONJ
dti-1318	121	13	they	they	PRON
dti-1318	121	14	appear	appear	VERB
dti-1318	121	15	to	to	PART
dti-1318	121	16	have	have	VERB
dti-1318	121	17	no	no	DET
dti-1318	121	18	effect	effect	NOUN
dti-1318	121	19	on	on	ADP
dti-1318	121	20	cell	cell	NOUN
dti-1318	121	21	proliferation	proliferation	NOUN
dti-1318	121	22	(	(	PUNCT
dti-1318	121	23	campbell	campbell	PROPN
dti-1318	121	24	and	and	CCONJ
dti-1318	121	25	vogt	vogt	PROPN
dti-1318	121	26	,	,	PUNCT
dti-1318	121	27	1995	1995	NUM
dti-1318	121	28	)	)	PUNCT
dti-1318	121	29	.	.	PUNCT
dti-1318	122	1	it	it	PRON
dti-1318	122	2	is	be	AUX
dti-1318	122	3	suggested	suggest	VERB
dti-1318	122	4	that	that	SCONJ
dti-1318	122	5	direct	direct	ADJ
dti-1318	122	6	dietary	dietary	ADJ
dti-1318	122	7	intake	intake	NOUN
dti-1318	122	8	of	of	ADP
dti-1318	122	9	physeteric	physeteric	ADJ
dti-1318	122	10	acid	acid	PROPN
dti-1318	122	11	and	and	CCONJ
dti-1318	122	12	goshuyic	goshuyic	PROPN
dti-1318	122	13	acid	acid	PROPN
dti-1318	122	14	could	could	AUX
dti-1318	122	15	be	be	AUX
dti-1318	122	16	a	a	DET
dti-1318	122	17	useful	useful	ADJ
dti-1318	122	18	therapeutic	therapeutic	ADJ
dti-1318	122	19	strategy	strategy	NOUN
dti-1318	122	20	for	for	ADP
dti-1318	122	21	the	the	DET
dti-1318	122	22	treatment	treatment	NOUN
dti-1318	122	23	of	of	ADP
dti-1318	122	24	hiv-1	hiv-1	X
dti-1318	122	25	infections	infection	NOUN
dti-1318	122	26	.	.	PUNCT
dti-1318	123	1	however	however	ADV
dti-1318	123	2	,	,	PUNCT
dti-1318	123	3	the	the	DET
dti-1318	123	4	effect	effect	NOUN
dti-1318	123	5	of	of	ADP
dti-1318	123	6	long	long	ADJ
dti-1318	123	7	term	term	NOUN
dti-1318	123	8	intake	intake	NOUN
dti-1318	123	9	of	of	ADP
dti-1318	123	10	these	these	DET
dti-1318	123	11	unsaturated	unsaturate	VERB
dti-1318	123	12	fatty	fatty	NOUN
dti-1318	123	13	acids	acid	NOUN
dti-1318	123	14	and	and	CCONJ
dti-1318	123	15	their	their	PRON
dti-1318	123	16	effect	effect	NOUN
dti-1318	123	17	on	on	ADP
dti-1318	123	18	n	n	ADV
dti-1318	123	19	-	-	PUNCT
dti-1318	123	20	myristoylated	myristoylate	VERB
dti-1318	123	21	signaling	signal	VERB
dti-1318	123	22	proteins	protein	NOUN
dti-1318	123	23	such	such	ADJ
dti-1318	123	24	as	as	ADP
dti-1318	123	25	src	src	NOUN
dti-1318	123	26	,	,	PUNCT
dti-1318	123	27	g	g	NOUN
dti-1318	123	28	-	-	PUNCT
dti-1318	123	29	proteins	protein	NOUN
dti-1318	123	30	,	,	PUNCT
dti-1318	123	31	arf	arf	NOUN
dti-1318	123	32	and	and	CCONJ
dti-1318	123	33	heterogeneously	heterogeneously	ADV
dti-1318	123	34	n	n	CCONJ
dti-1318	123	35	-	-	PUNCT
dti-1318	123	36	acylated	acylate	VERB
dti-1318	123	37	retinal	retinal	ADJ
dti-1318	123	38	proteins	protein	NOUN
dti-1318	123	39	needs	need	VERB
dti-1318	123	40	to	to	PART
dti-1318	123	41	be	be	AUX
dti-1318	123	42	assessed	assess	VERB
dti-1318	123	43	(	(	PUNCT
dti-1318	123	44	lindwasser	lindwasser	ADJ
dti-1318	123	45	and	and	CCONJ
dti-1318	123	46	resh	resh	NOUN
dti-1318	123	47	,	,	PUNCT
dti-1318	123	48	2002	2002	NUM
dti-1318	123	49	)	)	PUNCT
dti-1318	123	50	.	.	PUNCT
dti-1318	124	1	recent	recent	ADJ
dti-1318	124	2	studies	study	NOUN
dti-1318	124	3	also	also	ADV
dti-1318	124	4	indicate	indicate	VERB
dti-1318	124	5	a	a	DET
dti-1318	124	6	role	role	NOUN
dti-1318	124	7	for	for	ADP
dti-1318	124	8	phosphatidylinositide	phosphatidylinositide	ADJ
dti-1318	124	9	4,5	4,5	NUM
dti-1318	124	10	-	-	PUNCT
dti-1318	124	11	bisphosphate	bisphosphate	NOUN
dti-1318	124	12	[	[	X
dti-1318	124	13	pi(4,5)p2	pi(4,5)p2	X
dti-1318	124	14	]	]	PUNCT
dti-1318	124	15	in	in	ADP
dti-1318	124	16	regulating	regulate	VERB
dti-1318	124	17	gag	gag	NOUN
dti-1318	124	18	localization	localization	NOUN
dti-1318	124	19	(	(	PUNCT
dti-1318	124	20	ono	ono	PROPN
dti-1318	124	21	et	et	PROPN
dti-1318	124	22	al	al	PROPN
dti-1318	124	23	.	.	PROPN
dti-1318	124	24	2004	2004	NUM
dti-1318	124	25	)	)	PUNCT
dti-1318	124	26	.	.	PUNCT
dti-1318	125	1	in	in	ADP
dti-1318	125	2	hiv-1	hiv-1	PRON
dti-1318	125	3	,	,	PUNCT
dti-1318	125	4	binding	bind	VERB
dti-1318	125	5	of	of	ADP
dti-1318	125	6	pi(4,5)p2	pi(4,5)p2	NOUN
dti-1318	125	7	to	to	ADP
dti-1318	125	8	the	the	DET
dti-1318	125	9	ma	ma	PROPN
dti-1318	125	10	domain	domain	NOUN
dti-1318	125	11	in	in	ADP
dti-1318	125	12	gag	gag	NOUN
dti-1318	125	13	activates	activate	VERB
dti-1318	125	14	the	the	DET
dti-1318	125	15	“	"	PUNCT
dti-1318	125	16	myristyol	myristyol	NOUN
dti-1318	125	17	switch	switch	VERB
dti-1318	125	18	”	"	PUNCT
dti-1318	125	19	and	and	CCONJ
dti-1318	125	20	also	also	ADV
dti-1318	125	21	acts	act	VERB
dti-1318	125	22	as	as	ADP
dti-1318	125	23	the	the	DET
dti-1318	125	24	point	point	NOUN
dti-1318	125	25	of	of	ADP
dti-1318	125	26	membrane	membrane	NOUN
dti-1318	125	27	attachment	attachment	NOUN
dti-1318	125	28	(	(	PUNCT
dti-1318	125	29	saad	saad	PROPN
dti-1318	125	30	et	et	PROPN
dti-1318	125	31	al	al	PROPN
dti-1318	125	32	.	.	PROPN
dti-1318	125	33	2006	2006	NUM
dti-1318	125	34	)	)	PUNCT
dti-1318	125	35	.	.	PUNCT
dti-1318	126	1	the	the	DET
dti-1318	126	2	binding	bind	VERB
dti-1318	126	3	site	site	NOUN
dti-1318	126	4	of	of	ADP
dti-1318	126	5	pi(4,5)p2	pi(4,5)p2	PROPN
dti-1318	126	6	on	on	ADP
dti-1318	126	7	ma	ma	PROPN
dti-1318	126	8	is	be	AUX
dti-1318	126	9	highly	highly	ADV
dti-1318	126	10	conserved	conserve	VERB
dti-1318	126	11	amongst	amongst	ADP
dti-1318	126	12	hiv-1	hiv-1	X
dti-1318	126	13	strains	strain	NOUN
dti-1318	126	14	and	and	CCONJ
dti-1318	126	15	therefore	therefore	ADV
dti-1318	126	16	represents	represent	VERB
dti-1318	126	17	an	an	DET
dti-1318	126	18	attractive	attractive	ADJ
dti-1318	126	19	antiviral	antiviral	ADJ
dti-1318	126	20	target	target	NOUN
dti-1318	126	21	(	(	PUNCT
dti-1318	126	22	shkriabai	shkriabai	NOUN
dti-1318	126	23	et	et	PROPN
dti-1318	126	24	al	al	PROPN
dti-1318	126	25	.	.	PROPN
dti-1318	126	26	2006	2006	NUM
dti-1318	126	27	;	;	PUNCT
dti-1318	126	28	saad	saad	PROPN
dti-1318	126	29	et	et	PROPN
dti-1318	126	30	al	al	PROPN
dti-1318	126	31	.	.	PROPN
dti-1318	126	32	2006	2006	NUM
dti-1318	126	33	)	)	PUNCT
dti-1318	126	34	.	.	PUNCT
dti-1318	127	1	targeting	target	VERB
dti-1318	127	2	hiv-1	hiv-1	PUNCT
dti-1318	127	3	ca	can	AUX
dti-1318	127	4	ca	can	AUX
dti-1318	127	5	plays	play	VERB
dti-1318	127	6	an	an	DET
dti-1318	127	7	important	important	ADJ
dti-1318	127	8	role	role	NOUN
dti-1318	127	9	in	in	ADP
dti-1318	127	10	the	the	DET
dti-1318	127	11	hiv-1	hiv-1	ADJ
dti-1318	127	12	life	life	NOUN
dti-1318	127	13	-	-	PUNCT
dti-1318	127	14	cycle	cycle	NOUN
dti-1318	127	15	by	by	ADP
dti-1318	127	16	promoting	promote	VERB
dti-1318	127	17	gag	gag	NOUN
dti-1318	127	18	-	-	PUNCT
dti-1318	127	19	gag	gag	NOUN
dti-1318	127	20	interactions	interaction	NOUN
dti-1318	127	21	during	during	ADP
dti-1318	127	22	virion	virion	NOUN
dti-1318	127	23	maturation	maturation	NOUN
dti-1318	127	24	.	.	PUNCT
dti-1318	128	1	the	the	DET
dti-1318	128	2	nand	nand	NOUN
dti-1318	128	3	c	c	X
dti-1318	128	4	-	-	PUNCT
dti-1318	128	5	terminal	terminal	ADJ
dti-1318	128	6	domains	domain	NOUN
dti-1318	128	7	of	of	ADP
dti-1318	128	8	this	this	DET
dti-1318	128	9	protein	protein	NOUN
dti-1318	128	10	serve	serve	VERB
dti-1318	128	11	distinct	distinct	ADJ
dti-1318	128	12	functions	function	NOUN
dti-1318	128	13	.	.	PUNCT
dti-1318	129	1	as	as	SCONJ
dti-1318	129	2	shown	show	VERB
dti-1318	129	3	by	by	ADP
dti-1318	129	4	mutational	mutational	ADJ
dti-1318	129	5	analysis	analysis	NOUN
dti-1318	129	6	,	,	PUNCT
dti-1318	129	7	the	the	DET
dti-1318	129	8	n	n	PRON
dti-1318	129	9	terminal	terminal	ADJ
dti-1318	129	10	domain	domain	NOUN
dti-1318	129	11	of	of	ADP
dti-1318	129	12	ca	ca	NOUN
dti-1318	129	13	(	(	PUNCT
dti-1318	129	14	n	n	CCONJ
dti-1318	129	15	-	-	PUNCT
dti-1318	129	16	ca	ca	NOUN
dti-1318	129	17	)	)	PUNCT
dti-1318	129	18	,	,	PUNCT
dti-1318	129	19	otherwise	otherwise	ADV
dti-1318	129	20	known	know	VERB
dti-1318	129	21	as	as	ADP
dti-1318	129	22	the	the	DET
dti-1318	129	23	ntd	ntd	NOUN
dti-1318	129	24	,	,	PUNCT
dti-1318	129	25	is	be	AUX
dti-1318	129	26	responsible	responsible	ADJ
dti-1318	129	27	for	for	ADP
dti-1318	129	28	maintaining	maintain	VERB
dti-1318	129	29	the	the	DET
dti-1318	129	30	proper	proper	ADJ
dti-1318	129	31	conformation	conformation	NOUN
dti-1318	129	32	of	of	ADP
dti-1318	129	33	ca	ca	NOUN
dti-1318	129	34	during	during	ADP
dti-1318	129	35	the	the	DET
dti-1318	129	36	assembly	assembly	NOUN
dti-1318	129	37	process	process	NOUN
dti-1318	129	38	(	(	PUNCT
dti-1318	129	39	worthylake	worthylake	VERB
dti-1318	129	40	et	et	PROPN
dti-1318	129	41	al	al	PROPN
dti-1318	129	42	.	.	PROPN
dti-1318	129	43	1999	1999	NUM
dti-1318	129	44	;	;	PUNCT
dti-1318	129	45	li	li	PROPN
dti-1318	129	46	et	et	PROPN
dti-1318	129	47	al	al	PROPN
dti-1318	129	48	.	.	PROPN
dti-1318	129	49	2000	2000	NUM
dti-1318	129	50	)	)	PUNCT
dti-1318	129	51	.	.	PUNCT
dti-1318	130	1	the	the	DET
dti-1318	130	2	c	c	NOUN
dti-1318	130	3	-	-	PUNCT
dti-1318	130	4	terminal	terminal	ADJ
dti-1318	130	5	domain	domain	NOUN
dti-1318	130	6	of	of	ADP
dti-1318	130	7	ca	ca	NOUN
dti-1318	130	8	(	(	PUNCT
dti-1318	130	9	c	c	X
dti-1318	130	10	-	-	PUNCT
dti-1318	130	11	ca	ca	NOUN
dti-1318	130	12	)	)	PUNCT
dti-1318	130	13	or	or	CCONJ
dti-1318	130	14	the	the	DET
dti-1318	130	15	ctd	ctd	NOUN
dti-1318	130	16	,	,	PUNCT
dti-1318	130	17	is	be	AUX
dti-1318	130	18	critical	critical	ADJ
dti-1318	130	19	for	for	ADP
dti-1318	130	20	gag	gag	NOUN
dti-1318	130	21	-	-	PUNCT
dti-1318	130	22	gag	gag	NOUN
dti-1318	130	23	interactions	interaction	NOUN
dti-1318	130	24	during	during	ADP
dti-1318	130	25	assembly	assembly	NOUN
dti-1318	130	26	and	and	CCONJ
dti-1318	130	27	maturation	maturation	NOUN
dti-1318	130	28	(	(	PUNCT
dti-1318	130	29	gamble	gamble	VERB
dti-1318	130	30	et	et	PROPN
dti-1318	130	31	al	al	PROPN
dti-1318	130	32	.	.	PROPN
dti-1318	130	33	1996	1996	NUM
dti-1318	130	34	;	;	PUNCT
dti-1318	130	35	gamble	gamble	NOUN
dti-1318	130	36	et	et	PROPN
dti-1318	130	37	al	al	PROPN
dti-1318	130	38	.	.	PROPN
dti-1318	130	39	1997	1997	NUM
dti-1318	130	40	)	)	PUNCT
dti-1318	130	41	and	and	CCONJ
dti-1318	130	42	described	describe	VERB
dti-1318	130	43	mutations	mutation	NOUN
dti-1318	130	44	in	in	ADP
dti-1318	130	45	this	this	DET
dti-1318	130	46	region	region	NOUN
dti-1318	130	47	have	have	VERB
dti-1318	130	48	major	major	ADJ
dti-1318	130	49	consequences	consequence	NOUN
dti-1318	130	50	on	on	ADP
dti-1318	130	51	virion	virion	NOUN
dti-1318	130	52	maturation	maturation	NOUN
dti-1318	130	53	and	and	CCONJ
dti-1318	130	54	infectivity	infectivity	NOUN
dti-1318	130	55	(	(	PUNCT
dti-1318	130	56	von	von	PROPN
dti-1318	130	57	schwedler	schwedler	NOUN
dti-1318	130	58	et	et	PROPN
dti-1318	130	59	al	al	PROPN
dti-1318	130	60	.	.	PROPN
dti-1318	130	61	2003	2003	NUM
dti-1318	130	62	;	;	PUNCT
dti-1318	130	63	ganser	ganser	NOUN
dti-1318	130	64	-	-	PUNCT
dti-1318	130	65	pornillos	pornillos	NOUN
dti-1318	130	66	et	et	PROPN
dti-1318	130	67	al	al	PROPN
dti-1318	130	68	.	.	PROPN
dti-1318	130	69	2004	2004	NUM
dti-1318	130	70	)	)	PUNCT
dti-1318	130	71	.	.	PUNCT
dti-1318	131	1	the	the	DET
dti-1318	131	2	nmr	nmr	NOUN
dti-1318	131	3	structure	structure	NOUN
dti-1318	131	4	of	of	ADP
dti-1318	131	5	ca	can	AUX
dti-1318	131	6	has	have	AUX
dti-1318	131	7	demonstrated	demonstrate	VERB
dti-1318	131	8	that	that	SCONJ
dti-1318	131	9	the	the	DET
dti-1318	131	10	protein	protein	NOUN
dti-1318	131	11	consists	consist	VERB
dti-1318	131	12	mainly	mainly	ADV
dti-1318	131	13	of	of	ADP
dti-1318	131	14	seven	seven	NUM
dti-1318	131	15	α	α	NOUN
dti-1318	131	16	-	-	PUNCT
dti-1318	131	17	helices	helix	NOUN
dti-1318	131	18	,	,	PUNCT
dti-1318	131	19	two	two	NUM
dti-1318	131	20	β	β	NOUN
dti-1318	131	21	-	-	NOUN
dti-1318	131	22	hairpins	hairpin	NOUN
dti-1318	131	23	and	and	CCONJ
dti-1318	131	24	a	a	DET
dti-1318	131	25	loop	loop	NOUN
dti-1318	131	26	structure	structure	NOUN
dti-1318	131	27	(	(	PUNCT
dti-1318	131	28	momany	momany	NOUN
dti-1318	131	29	et	et	PROPN
dti-1318	131	30	al	al	PROPN
dti-1318	131	31	.	.	PROPN
dti-1318	131	32	1996	1996	NUM
dti-1318	131	33	;	;	PUNCT
dti-1318	131	34	gitti	gitti	PROPN
dti-1318	131	35	et	et	PROPN
dti-1318	131	36	al	al	PROPN
dti-1318	131	37	.	.	PROPN
dti-1318	131	38	1996	1996	NUM
dti-1318	131	39	)	)	PUNCT
dti-1318	131	40	.	.	PUNCT
dti-1318	132	1	five	five	NUM
dti-1318	132	2	of	of	ADP
dti-1318	132	3	the	the	DET
dti-1318	132	4	α	α	NOUN
dti-1318	132	5	-	-	PUNCT
dti-1318	132	6	helices	helix	NOUN
dti-1318	132	7	form	form	VERB
dti-1318	132	8	a	a	DET
dti-1318	132	9	coiled	coil	VERB
dti-1318	132	10	-	-	PUNCT
dti-1318	132	11	coiled	coil	VERB
dti-1318	132	12	structure	structure	NOUN
dti-1318	132	13	while	while	SCONJ
dti-1318	132	14	one	one	NUM
dti-1318	132	15	of	of	ADP
dti-1318	132	16	the	the	DET
dti-1318	132	17	β	β	NOUN
dti-1318	132	18	-	-	NOUN
dti-1318	132	19	hairpins	hairpin	NOUN
dti-1318	132	20	is	be	AUX
dti-1318	132	21	located	locate	VERB
dti-1318	132	22	on	on	ADP
dti-1318	132	23	the	the	DET
dti-1318	132	24	surface	surface	NOUN
dti-1318	132	25	of	of	ADP
dti-1318	132	26	the	the	DET
dti-1318	132	27	n	n	CCONJ
dti-1318	132	28	-	-	PUNCT
dti-1318	132	29	terminal	terminal	ADJ
dti-1318	132	30	domain	domain	NOUN
dti-1318	132	31	of	of	ADP
dti-1318	132	32	the	the	DET
dti-1318	132	33	protein	protein	NOUN
dti-1318	132	34	(	(	PUNCT
dti-1318	132	35	momany	momany	NOUN
dti-1318	132	36	et	et	PROPN
dti-1318	132	37	al	al	PROPN
dti-1318	132	38	.	.	PROPN
dti-1318	132	39	1996	1996	NUM
dti-1318	132	40	)	)	PUNCT
dti-1318	132	41	.	.	PUNCT
dti-1318	133	1	the	the	DET
dti-1318	133	2	second	second	ADJ
dti-1318	133	3	β	β	X
dti-1318	133	4	-	-	NOUN
dti-1318	133	5	hairpin	hairpin	NOUN
dti-1318	133	6	is	be	AUX
dti-1318	133	7	predicted	predict	VERB
dti-1318	133	8	to	to	PART
dti-1318	133	9	be	be	AUX
dti-1318	133	10	formed	form	VERB
dti-1318	133	11	after	after	ADP
dti-1318	133	12	cleavage	cleavage	NOUN
dti-1318	133	13	by	by	ADP
dti-1318	133	14	the	the	DET
dti-1318	133	15	hiv-1	hiv-1	ADJ
dti-1318	133	16	pr	pr	X
dti-1318	133	17	(	(	PUNCT
dti-1318	133	18	tang	tang	NOUN
dti-1318	133	19	et	et	PROPN
dti-1318	133	20	al	al	PROPN
dti-1318	133	21	.	.	PROPN
dti-1318	133	22	2002	2002	NUM
dti-1318	133	23	)	)	PUNCT
dti-1318	133	24	.	.	PUNCT
dti-1318	134	1	cleavage	cleavage	NOUN
dti-1318	134	2	of	of	ADP
dti-1318	134	3	ca	ca	NOUN
dti-1318	134	4	from	from	ADP
dti-1318	134	5	its	its	PRON
dti-1318	134	6	neighbouring	neighbouring	ADJ
dti-1318	134	7	proteins	protein	NOUN
dti-1318	134	8	is	be	AUX
dti-1318	134	9	necessary	necessary	ADJ
dti-1318	134	10	for	for	ADP
dti-1318	134	11	core	core	NOUN
dti-1318	134	12	condensation	condensation	NOUN
dti-1318	134	13	and	and	CCONJ
dti-1318	134	14	conical	conical	PROPN
dti-1318	134	15	capsid	capsid	PROPN
dti-1318	134	16	shell	shell	NOUN
dti-1318	134	17	formation	formation	NOUN
dti-1318	134	18	(	(	PUNCT
dti-1318	134	19	vogt	vogt	PROPN
dti-1318	134	20	,	,	PUNCT
dti-1318	134	21	1996	1996	NUM
dti-1318	134	22	;	;	PUNCT
dti-1318	134	23	wiegers	wieger	NOUN
dti-1318	134	24	et	et	PROPN
dti-1318	134	25	al	al	PROPN
dti-1318	134	26	.	.	PROPN
dti-1318	134	27	1998	1998	NUM
dti-1318	134	28	)	)	PUNCT
dti-1318	134	29	.	.	PUNCT
dti-1318	135	1	compounds	compound	VERB
dti-1318	135	2	that	that	PRON
dti-1318	135	3	bind	bind	VERB
dti-1318	135	4	to	to	ADP
dti-1318	135	5	these	these	DET
dti-1318	135	6	regions	region	NOUN
dti-1318	135	7	would	would	AUX
dti-1318	135	8	be	be	AUX
dti-1318	135	9	expected	expect	VERB
dti-1318	135	10	to	to	PART
dti-1318	135	11	disrupt	disrupt	VERB
dti-1318	135	12	proper	proper	ADJ
dti-1318	135	13	ca	can	AUX
dti-1318	135	14	shell	shell	VERB
dti-1318	135	15	formation	formation	NOUN
dti-1318	135	16	and	and	CCONJ
dti-1318	135	17	virion	virion	NOUN
dti-1318	135	18	infectivity	infectivity	NOUN
dti-1318	135	19	making	make	VERB
dti-1318	135	20	ca	can	AUX
dti-1318	135	21	an	an	DET
dti-1318	135	22	important	important	ADJ
dti-1318	135	23	and	and	CCONJ
dti-1318	135	24	attractive	attractive	ADJ
dti-1318	135	25	target	target	NOUN
dti-1318	135	26	for	for	ADP
dti-1318	135	27	the	the	DET
dti-1318	135	28	development	development	NOUN
dti-1318	135	29	of	of	ADP
dti-1318	135	30	antiretroviral	antiretroviral	ADJ
dti-1318	135	31	agents	agent	NOUN
dti-1318	135	32	.	.	PUNCT
dti-1318	136	1	a	a	DET
dti-1318	136	2	proof	proof	NOUN
dti-1318	136	3	of	of	ADP
dti-1318	136	4	concept	concept	NOUN
dti-1318	136	5	study	study	NOUN
dti-1318	136	6	,	,	PUNCT
dti-1318	136	7	demonstrating	demonstrate	VERB
dti-1318	136	8	the	the	DET
dti-1318	136	9	potential	potential	NOUN
dti-1318	136	10	of	of	ADP
dti-1318	136	11	inhibiting	inhibit	VERB
dti-1318	136	12	ca	ca	NOUN
dti-1318	136	13	-	-	PUNCT
dti-1318	136	14	ca	ca	NOUN
dti-1318	136	15	interactions	interaction	NOUN
dti-1318	136	16	as	as	ADP
dti-1318	136	17	an	an	DET
dti-1318	136	18	antiretroviral	antiretroviral	ADJ
dti-1318	136	19	target	target	NOUN
dti-1318	136	20	has	have	AUX
dti-1318	136	21	been	be	AUX
dti-1318	136	22	published	publish	VERB
dti-1318	136	23	(	(	PUNCT
dti-1318	136	24	tang	tang	X
dti-1318	136	25	et	et	PROPN
dti-1318	136	26	al	al	PROPN
dti-1318	136	27	.	.	PROPN
dti-1318	136	28	2003	2003	NUM
dti-1318	136	29	)	)	PUNCT
dti-1318	136	30	.	.	PUNCT
dti-1318	137	1	computational	computational	ADJ
dti-1318	137	2	high	high	ADJ
dti-1318	137	3	throughput	throughput	NOUN
dti-1318	137	4	screening	screening	NOUN
dti-1318	137	5	of	of	ADP
dti-1318	137	6	a	a	DET
dti-1318	137	7	small	small	ADJ
dti-1318	137	8	molecule	molecule	NOUN
dti-1318	137	9	library	library	NOUN
dti-1318	137	10	and	and	CCONJ
dti-1318	137	11	nmr	nmr	NOUN
dti-1318	137	12	analysis	analysis	NOUN
dti-1318	137	13	for	for	ADP
dti-1318	137	14	binding	bind	VERB
dti-1318	137	15	specifi	specifi	PROPN
dti-1318	137	16	city	city	PROPN
dti-1318	137	17	resulted	result	VERB
dti-1318	137	18	in	in	ADP
dti-1318	137	19	the	the	DET
dti-1318	137	20	identifi	identifi	NOUN
dti-1318	137	21	cation	cation	NOUN
dti-1318	137	22	of	of	ADP
dti-1318	137	23	cap-1	cap-1	PUNCT
dti-1318	137	24	and	and	CCONJ
dti-1318	137	25	cap-2	cap-2	PUNCT
dti-1318	137	26	which	which	PRON
dti-1318	137	27	bind	bind	VERB
dti-1318	137	28	to	to	ADP
dti-1318	137	29	an	an	DET
dti-1318	137	30	apical	apical	ADJ
dti-1318	137	31	site	site	NOUN
dti-1318	137	32	on	on	ADP
dti-1318	137	33	the	the	DET
dti-1318	137	34	ntd	ntd	NOUN
dti-1318	137	35	of	of	ADP
dti-1318	137	36	both	both	CCONJ
dti-1318	137	37	immature	immature	ADJ
dti-1318	137	38	and	and	CCONJ
dti-1318	137	39	mature	mature	ADJ
dti-1318	137	40	ca	ca	NOUN
dti-1318	137	41	(	(	PUNCT
dti-1318	137	42	tang	tang	X
dti-1318	137	43	et	et	PROPN
dti-1318	137	44	al	al	PROPN
dti-1318	137	45	.	.	PROPN
dti-1318	137	46	2003	2003	NUM
dti-1318	137	47	)	)	PUNCT
dti-1318	137	48	.	.	PUNCT
dti-1318	138	1	while	while	SCONJ
dti-1318	138	2	cap-2	cap-2	NUM
dti-1318	138	3	,	,	PUNCT
dti-1318	138	4	is	be	AUX
dti-1318	138	5	toxic	toxic	ADJ
dti-1318	138	6	to	to	ADP
dti-1318	138	7	u1	u1	NOUN
dti-1318	138	8	cells	cell	NOUN
dti-1318	138	9	,	,	PUNCT
dti-1318	138	10	cap-1	cap-1	PUNCT
dti-1318	138	11	reduces	reduce	VERB
dti-1318	138	12	viral	viral	ADJ
dti-1318	138	13	infectivity	infectivity	NOUN
dti-1318	138	14	by	by	ADP
dti-1318	138	15	95	95	NUM
dti-1318	138	16	%	%	NOUN
dti-1318	138	17	at	at	ADP
dti-1318	138	18	100	100	NUM
dti-1318	138	19	µm	µm	NOUN
dti-1318	138	20	.	.	PUNCT
dti-1318	139	1	the	the	DET
dti-1318	139	2	released	release	VERB
dti-1318	139	3	virions	virion	NOUN
dti-1318	139	4	lack	lack	VERB
dti-1318	139	5	cone	cone	NOUN
dti-1318	139	6	shaped	shape	VERB
dti-1318	139	7	cores	core	NOUN
dti-1318	139	8	and	and	CCONJ
dti-1318	139	9	resemble	resemble	VERB
dti-1318	139	10	viral	viral	ADJ
dti-1318	139	11	particles	particle	NOUN
dti-1318	139	12	that	that	PRON
dti-1318	139	13	have	have	AUX
dti-1318	139	14	been	be	AUX
dti-1318	139	15	observed	observe	VERB
dti-1318	139	16	in	in	ADP
dti-1318	139	17	hiv-1	hiv-1	VERB
dti-1318	139	18	expressing	express	VERB
dti-1318	139	19	mutations	mutation	NOUN
dti-1318	139	20	that	that	PRON
dti-1318	139	21	disrupt	disrupt	VERB
dti-1318	139	22	ca	ca	NOUN
dti-1318	139	23	-	-	PUNCT
dti-1318	139	24	ca	ca	NOUN
dti-1318	139	25	interactions	interaction	NOUN
dti-1318	139	26	(	(	PUNCT
dti-1318	139	27	dorfman	dorfman	PROPN
dti-1318	139	28	et	et	PROPN
dti-1318	139	29	al	al	PROPN
dti-1318	139	30	.	.	PROPN
dti-1318	139	31	1994	1994	NUM
dti-1318	139	32	;	;	PUNCT
dti-1318	139	33	reicin	reicin	NOUN
dti-1318	139	34	et	et	PROPN
dti-1318	139	35	al	al	PROPN
dti-1318	139	36	.	.	PROPN
dti-1318	139	37	1996	1996	NUM
dti-1318	139	38	;	;	PUNCT
dti-1318	139	39	von	von	PROPN
dti-1318	139	40	schwedler	schwedler	NOUN
dti-1318	139	41	et	et	PROPN
dti-1318	139	42	al	al	PROPN
dti-1318	139	43	.	.	PROPN
dti-1318	139	44	2003	2003	NUM
dti-1318	139	45	;	;	PUNCT
dti-1318	139	46	166	166	NUM
dti-1318	139	47	wapling	waple	VERB
dti-1318	139	48	et	et	PROPN
dti-1318	139	49	al	al	PROPN
dti-1318	139	50	drug	drug	PROPN
dti-1318	139	51	target	target	NOUN
dti-1318	139	52	insights	insight	NOUN
dti-1318	139	53	2007	2007	NUM
dti-1318	139	54	:	:	PUNCT
dti-1318	139	55	2	2	NUM
dti-1318	139	56	lanman	lanman	NOUN
dti-1318	139	57	et	et	PROPN
dti-1318	139	58	al	al	PROPN
dti-1318	139	59	.	.	PROPN
dti-1318	139	60	2003	2003	NUM
dti-1318	139	61	)	)	PUNCT
dti-1318	139	62	.	.	PUNCT
dti-1318	140	1	despite	despite	SCONJ
dti-1318	140	2	aberrant	aberrant	ADJ
dti-1318	140	3	viral	viral	ADJ
dti-1318	140	4	morphology	morphology	NOUN
dti-1318	140	5	cap-1	cap-1	PUNCT
dti-1318	140	6	does	do	AUX
dti-1318	140	7	not	not	PART
dti-1318	140	8	affect	affect	VERB
dti-1318	140	9	viral	viral	ADJ
dti-1318	140	10	particle	particle	NOUN
dti-1318	140	11	release	release	NOUN
dti-1318	140	12	or	or	CCONJ
dti-1318	140	13	proteolytic	proteolytic	ADJ
dti-1318	140	14	processing	processing	NOUN
dti-1318	140	15	(	(	PUNCT
dti-1318	140	16	tang	tang	X
dti-1318	140	17	et	et	PROPN
dti-1318	140	18	al	al	PROPN
dti-1318	140	19	.	.	PROPN
dti-1318	140	20	2003	2003	NUM
dti-1318	140	21	)	)	PUNCT
dti-1318	140	22	.	.	PUNCT
dti-1318	140	23	cap-1	cap-1	PUNCT
dti-1318	140	24	and	and	CCONJ
dti-1318	140	25	cap-2	cap-2	PRON
dti-1318	140	26	bind	bind	VERB
dti-1318	140	27	to	to	ADP
dti-1318	140	28	a	a	DET
dti-1318	140	29	common	common	ADJ
dti-1318	140	30	site	site	NOUN
dti-1318	140	31	within	within	ADP
dti-1318	140	32	the	the	PRON
dti-1318	140	33	ntd	ntd	NOUN
dti-1318	140	34	thus	thus	ADV
dti-1318	140	35	preventing	prevent	VERB
dti-1318	140	36	ca	can	AUX
dti-1318	140	37	-	-	PUNCT
dti-1318	140	38	ca	ca	NOUN
dti-1318	140	39	interactions	interaction	NOUN
dti-1318	140	40	and	and	CCONJ
dti-1318	140	41	proper	proper	ADJ
dti-1318	140	42	gag	gag	NOUN
dti-1318	140	43	assembly	assembly	NOUN
dti-1318	140	44	.	.	PUNCT
dti-1318	141	1	peptides	peptide	NOUN
dti-1318	141	2	derived	derive	VERB
dti-1318	141	3	from	from	ADP
dti-1318	141	4	hiv-1	hiv-1	PUNCT
dti-1318	141	5	ca	can	AUX
dti-1318	141	6	have	have	AUX
dti-1318	141	7	also	also	ADV
dti-1318	141	8	been	be	AUX
dti-1318	141	9	described	describe	VERB
dti-1318	141	10	to	to	PART
dti-1318	141	11	affect	affect	VERB
dti-1318	141	12	viral	viral	ADJ
dti-1318	141	13	morphogenesis	morphogenesis	NOUN
dti-1318	141	14	by	by	ADP
dti-1318	141	15	interfering	interfere	VERB
dti-1318	141	16	with	with	ADP
dti-1318	141	17	capsid	capsid	ADJ
dti-1318	141	18	formation	formation	NOUN
dti-1318	141	19	(	(	PUNCT
dti-1318	141	20	niedrig	niedrig	NOUN
dti-1318	141	21	et	et	PROPN
dti-1318	141	22	al	al	PROPN
dti-1318	141	23	.	.	PROPN
dti-1318	141	24	1994	1994	NUM
dti-1318	141	25	)	)	PUNCT
dti-1318	141	26	.	.	PUNCT
dti-1318	142	1	the	the	DET
dti-1318	142	2	synthetic	synthetic	ADJ
dti-1318	142	3	peptide	peptide	NOUN
dti-1318	142	4	,	,	PUNCT
dti-1318	142	5	paatleemmta	paatleemmta	NOUN
dti-1318	142	6	,	,	PUNCT
dti-1318	142	7	inhibits	inhibit	VERB
dti-1318	142	8	hiv-1	hiv-1	ADJ
dti-1318	142	9	replication	replication	NOUN
dti-1318	142	10	in	in	ADP
dti-1318	142	11	cell	cell	NOUN
dti-1318	142	12	culture	culture	NOUN
dti-1318	142	13	assays	assay	NOUN
dti-1318	142	14	at	at	ADP
dti-1318	142	15	20–200	20–200	PROPN
dti-1318	142	16	µg	µg	ADV
dti-1318	142	17	/	/	SYM
dti-1318	142	18	ml	ml	NOUN
dti-1318	142	19	and	and	CCONJ
dti-1318	142	20	results	result	NOUN
dti-1318	142	21	in	in	ADP
dti-1318	142	22	the	the	DET
dti-1318	142	23	production	production	NOUN
dti-1318	142	24	of	of	ADP
dti-1318	142	25	immature	immature	ADJ
dti-1318	142	26	and	and	CCONJ
dti-1318	142	27	aberrant	aberrant	ADJ
dti-1318	142	28	viral	viral	ADJ
dti-1318	142	29	particles	particle	NOUN
dti-1318	142	30	(	(	PUNCT
dti-1318	142	31	niedrig	niedrig	NOUN
dti-1318	142	32	et	et	PROPN
dti-1318	142	33	al	al	PROPN
dti-1318	142	34	.	.	PROPN
dti-1318	142	35	1994	1994	NUM
dti-1318	142	36	)	)	PUNCT
dti-1318	142	37	.	.	PUNCT
dti-1318	143	1	tripeptide	tripeptide	ADJ
dti-1318	143	2	amides	amide	NOUN
dti-1318	143	3	derived	derive	VERB
dti-1318	143	4	from	from	ADP
dti-1318	143	5	the	the	DET
dti-1318	143	6	carboxyl	carboxyl	NOUN
dti-1318	143	7	terminus	terminus	NOUN
dti-1318	143	8	of	of	ADP
dti-1318	143	9	ca	can	AUX
dti-1318	143	10	inhibit	inhibit	VERB
dti-1318	143	11	hiv-1	hiv-1	ADJ
dti-1318	143	12	replication	replication	NOUN
dti-1318	143	13	,	,	PUNCT
dti-1318	143	14	with	with	ADP
dti-1318	143	15	the	the	DET
dti-1318	143	16	three	three	NUM
dti-1318	143	17	most	most	ADV
dti-1318	143	18	potent	potent	ADJ
dti-1318	143	19	peptides	peptide	NOUN
dti-1318	143	20	interacting	interact	VERB
dti-1318	143	21	with	with	ADP
dti-1318	143	22	ca	ca	NOUN
dti-1318	143	23	as	as	SCONJ
dti-1318	143	24	demonstrated	demonstrate	VERB
dti-1318	143	25	by	by	ADP
dti-1318	143	26	capillary	capillary	ADJ
dti-1318	143	27	electrophoresis	electrophoresis	NOUN
dti-1318	143	28	analysis	analysis	NOUN
dti-1318	143	29	(	(	PUNCT
dti-1318	143	30	hoglund	hoglund	NOUN
dti-1318	143	31	et	et	PROPN
dti-1318	143	32	al	al	PROPN
dti-1318	143	33	.	.	PROPN
dti-1318	143	34	2002	2002	NUM
dti-1318	143	35	)	)	PUNCT
dti-1318	143	36	.	.	PUNCT
dti-1318	144	1	glycyl	glycyl	NOUN
dti-1318	144	2	-	-	PUNCT
dti-1318	144	3	prolyl	prolyl	VERB
dti-1318	144	4	-	-	PUNCT
dti-1318	144	5	glycine	glycine	NOUN
dti-1318	144	6	-	-	PUNCT
dti-1318	144	7	amide	amide	NOUN
dti-1318	144	8	(	(	PUNCT
dti-1318	144	9	gpg	gpg	NOUN
dti-1318	144	10	-	-	PUNCT
dti-1318	144	11	nh2	nh2	NOUN
dti-1318	144	12	)	)	PUNCT
dti-1318	144	13	interferes	interfere	VERB
dti-1318	144	14	with	with	ADP
dti-1318	144	15	the	the	DET
dti-1318	144	16	formation	formation	NOUN
dti-1318	144	17	of	of	ADP
dti-1318	144	18	hiv-1	hiv-1	X
dti-1318	144	19	particles	particle	NOUN
dti-1318	144	20	with	with	ADP
dti-1318	144	21	a	a	DET
dti-1318	144	22	normal	normal	ADJ
dti-1318	144	23	conical	conical	NOUN
dti-1318	144	24	core	core	NOUN
dti-1318	144	25	structure	structure	NOUN
dti-1318	144	26	(	(	PUNCT
dti-1318	144	27	hoglund	hoglund	NOUN
dti-1318	144	28	et	et	PROPN
dti-1318	144	29	al	al	PROPN
dti-1318	144	30	.	.	PROPN
dti-1318	144	31	2002	2002	NUM
dti-1318	144	32	)	)	PUNCT
dti-1318	144	33	.	.	PUNCT
dti-1318	145	1	g	g	NOUN
dti-1318	145	2	-	-	PUNCT
dti-1318	145	3	nh2	nh2	NOUN
dti-1318	145	4	is	be	AUX
dti-1318	145	5	an	an	DET
dti-1318	145	6	active	active	ADJ
dti-1318	145	7	metabolite	metabolite	NOUN
dti-1318	145	8	of	of	ADP
dti-1318	145	9	gpg	gpg	NOUN
dti-1318	145	10	-	-	NOUN
dti-1318	145	11	nh2	nh2	NOUN
dti-1318	145	12	indicating	indicate	VERB
dti-1318	145	13	that	that	SCONJ
dti-1318	145	14	the	the	DET
dti-1318	145	15	latter	latter	ADJ
dti-1318	145	16	acts	act	VERB
dti-1318	145	17	as	as	ADP
dti-1318	145	18	a	a	DET
dti-1318	145	19	pro	pro	ADJ
dti-1318	145	20	-	-	ADJ
dti-1318	145	21	drug	drug	ADJ
dti-1318	145	22	(	(	PUNCT
dti-1318	145	23	andersson	andersson	PROPN
dti-1318	145	24	et	et	PROPN
dti-1318	145	25	al	al	PROPN
dti-1318	145	26	.	.	PROPN
dti-1318	145	27	2005	2005	NUM
dti-1318	145	28	)	)	PUNCT
dti-1318	145	29	.	.	PUNCT
dti-1318	146	1	however	however	ADV
dti-1318	146	2	,	,	PUNCT
dti-1318	146	3	the	the	DET
dti-1318	146	4	development	development	NOUN
dti-1318	146	5	of	of	ADP
dti-1318	146	6	hiv-1	hiv-1	X
dti-1318	146	7	resistance	resistance	NOUN
dti-1318	146	8	to	to	ADP
dti-1318	146	9	either	either	CCONJ
dti-1318	146	10	g	g	NOUN
dti-1318	146	11	-	-	PUNCT
dti-1318	146	12	nh2	nh2	NOUN
dti-1318	146	13	or	or	CCONJ
dti-1318	146	14	gpg	gpg	PROPN
dti-1318	146	15	-	-	PUNCT
dti-1318	146	16	nh2	nh2	NOUN
dti-1318	146	17	has	have	AUX
dti-1318	146	18	been	be	AUX
dti-1318	146	19	elusive	elusive	ADJ
dti-1318	146	20	suggesting	suggest	VERB
dti-1318	146	21	that	that	SCONJ
dti-1318	146	22	the	the	DET
dti-1318	146	23	peptides	peptide	NOUN
dti-1318	146	24	mediate	mediate	VERB
dti-1318	146	25	their	their	PRON
dti-1318	146	26	effects	effect	NOUN
dti-1318	146	27	through	through	ADP
dti-1318	146	28	a	a	DET
dti-1318	146	29	host	host	NOUN
dti-1318	146	30	cell	cell	NOUN
dti-1318	146	31	or	or	CCONJ
dti-1318	146	32	other	other	ADJ
dti-1318	146	33	factor	factor	NOUN
dti-1318	146	34	(	(	PUNCT
dti-1318	146	35	andersson	andersson	PROPN
dti-1318	146	36	et	et	PROPN
dti-1318	146	37	al	al	PROPN
dti-1318	146	38	.	.	PROPN
dti-1318	146	39	2004	2004	NUM
dti-1318	146	40	)	)	PUNCT
dti-1318	146	41	.	.	PUNCT
dti-1318	147	1	cai	cai	PROPN
dti-1318	147	2	,	,	PUNCT
dti-1318	147	3	a	a	DET
dti-1318	147	4	small	small	ADJ
dti-1318	147	5	peptide	peptide	NOUN
dti-1318	147	6	selected	select	VERB
dti-1318	147	7	by	by	ADP
dti-1318	147	8	phage	phage	NOUN
dti-1318	147	9	display	display	NOUN
dti-1318	147	10	screening	screening	NOUN
dti-1318	147	11	,	,	PUNCT
dti-1318	147	12	acts	act	VERB
dti-1318	147	13	as	as	ADP
dti-1318	147	14	an	an	DET
dti-1318	147	15	inhibitor	inhibitor	NOUN
dti-1318	147	16	of	of	ADP
dti-1318	147	17	the	the	DET
dti-1318	147	18	assembly	assembly	NOUN
dti-1318	147	19	of	of	ADP
dti-1318	147	20	immature	immature	ADJ
dti-1318	147	21	gag	gag	NOUN
dti-1318	147	22	in	in	ADP
dti-1318	147	23	vitro	vitro	X
dti-1318	147	24	(	(	PUNCT
dti-1318	147	25	sticht	sticht	PROPN
dti-1318	147	26	et	et	PROPN
dti-1318	147	27	al	al	PROPN
dti-1318	147	28	.	.	PROPN
dti-1318	147	29	2005	2005	NUM
dti-1318	147	30	;	;	PUNCT
dti-1318	147	31	ternois	ternois	NOUN
dti-1318	147	32	et	et	PROPN
dti-1318	147	33	al	al	PROPN
dti-1318	147	34	.	.	PROPN
dti-1318	147	35	2005	2005	NUM
dti-1318	147	36	)	)	PUNCT
dti-1318	147	37	.	.	PUNCT
dti-1318	148	1	cai	cai	PROPN
dti-1318	148	2	binds	bind	VERB
dti-1318	148	3	to	to	ADP
dti-1318	148	4	the	the	DET
dti-1318	148	5	c	c	NOUN
dti-1318	148	6	-	-	PUNCT
dti-1318	148	7	terminus	terminus	NOUN
dti-1318	148	8	of	of	ADP
dti-1318	148	9	ca	ca	NOUN
dti-1318	148	10	(	(	PUNCT
dti-1318	148	11	kd	kd	X
dti-1318	148	12	~	~	PUNCT
dti-1318	148	13	800	800	NUM
dti-1318	148	14	µm	µm	NOUN
dti-1318	148	15	)	)	PUNCT
dti-1318	148	16	,	,	PUNCT
dti-1318	148	17	thus	thus	ADV
dti-1318	148	18	preventing	prevent	VERB
dti-1318	148	19	the	the	DET
dti-1318	148	20	necessary	necessary	ADJ
dti-1318	148	21	conformational	conformational	ADJ
dti-1318	148	22	changes	change	NOUN
dti-1318	148	23	in	in	ADP
dti-1318	148	24	ca	ca	NOUN
dti-1318	148	25	that	that	PRON
dti-1318	148	26	lead	lead	VERB
dti-1318	148	27	to	to	ADP
dti-1318	148	28	the	the	DET
dti-1318	148	29	formation	formation	NOUN
dti-1318	148	30	of	of	ADP
dti-1318	148	31	mature	mature	ADJ
dti-1318	148	32	cores	core	NOUN
dti-1318	148	33	(	(	PUNCT
dti-1318	148	34	sticht	sticht	PROPN
dti-1318	148	35	et	et	PROPN
dti-1318	148	36	al	al	PROPN
dti-1318	148	37	.	.	PROPN
dti-1318	148	38	2005	2005	NUM
dti-1318	148	39	)	)	PUNCT
dti-1318	148	40	.	.	PUNCT
dti-1318	149	1	the	the	DET
dti-1318	149	2	structure	structure	NOUN
dti-1318	149	3	of	of	ADP
dti-1318	149	4	cai	cai	PROPN
dti-1318	149	5	complexed	complexe	VERB
dti-1318	149	6	with	with	ADP
dti-1318	149	7	ca	ca	NOUN
dti-1318	149	8	has	have	AUX
dti-1318	149	9	revealed	reveal	VERB
dti-1318	149	10	that	that	SCONJ
dti-1318	149	11	the	the	DET
dti-1318	149	12	cai	cai	PROPN
dti-1318	149	13	binding	bind	VERB
dti-1318	149	14	region	region	NOUN
dti-1318	149	15	is	be	AUX
dti-1318	149	16	a	a	DET
dti-1318	149	17	highly	highly	ADV
dti-1318	149	18	conserved	conserve	VERB
dti-1318	149	19	hydrophobic	hydrophobic	NOUN
dti-1318	149	20	pocket	pocket	NOUN
dti-1318	149	21	within	within	ADP
dti-1318	149	22	the	the	DET
dti-1318	149	23	c	c	NOUN
dti-1318	149	24	terminus	terminus	NOUN
dti-1318	149	25	of	of	ADP
dti-1318	149	26	ca	ca	NOUN
dti-1318	149	27	where	where	SCONJ
dti-1318	149	28	the	the	DET
dti-1318	149	29	peptide	peptide	NOUN
dti-1318	149	30	forms	form	VERB
dti-1318	149	31	an	an	DET
dti-1318	149	32	extra	extra	ADJ
dti-1318	149	33	α	α	NOUN
dti-1318	149	34	-	-	NOUN
dti-1318	149	35	helix	helix	NOUN
dti-1318	149	36	,	,	PUNCT
dti-1318	149	37	which	which	PRON
dti-1318	149	38	binds	bind	VERB
dti-1318	149	39	to	to	ADP
dti-1318	149	40	the	the	DET
dti-1318	149	41	four	four	NUM
dti-1318	149	42	α	α	NOUN
dti-1318	149	43	-	-	PUNCT
dti-1318	149	44	helices	helix	NOUN
dti-1318	149	45	of	of	ADP
dti-1318	149	46	ca	ca	NOUN
dti-1318	149	47	(	(	PUNCT
dti-1318	149	48	ternois	ternois	VERB
dti-1318	149	49	et	et	PROPN
dti-1318	149	50	al	al	PROPN
dti-1318	149	51	.	.	PROPN
dti-1318	149	52	2005	2005	NUM
dti-1318	149	53	)	)	PUNCT
dti-1318	149	54	.	.	PUNCT
dti-1318	150	1	the	the	DET
dti-1318	150	2	resulting	result	VERB
dti-1318	150	3	proteinpeptide	proteinpeptide	NOUN
dti-1318	150	4	complex	complex	NOUN
dti-1318	150	5	is	be	AUX
dti-1318	150	6	therefore	therefore	ADV
dti-1318	150	7	a	a	DET
dti-1318	150	8	fi	fi	NOUN
dti-1318	150	9	ve	ve	NOUN
dti-1318	150	10	α	α	VERB
dti-1318	150	11	-	-	PUNCT
dti-1318	150	12	helix	helix	ADJ
dti-1318	150	13	bundle	bundle	NOUN
dti-1318	150	14	with	with	ADP
dti-1318	150	15	reduced	reduced	ADJ
dti-1318	150	16	ca	ca	NOUN
dti-1318	150	17	-	-	PUNCT
dti-1318	150	18	ca	ca	NOUN
dti-1318	150	19	dimerization	dimerization	NOUN
dti-1318	150	20	contacts	contact	NOUN
dti-1318	150	21	that	that	PRON
dti-1318	150	22	destabilizes	destabilize	VERB
dti-1318	150	23	the	the	DET
dti-1318	150	24	dimer	dimer	NOUN
dti-1318	150	25	interface	interface	NOUN
dti-1318	150	26	.	.	PUNCT
dti-1318	151	1	binding	bind	VERB
dti-1318	151	2	of	of	ADP
dti-1318	151	3	cai	cai	PROPN
dti-1318	151	4	to	to	ADP
dti-1318	151	5	the	the	DET
dti-1318	151	6	c	c	NOUN
dti-1318	151	7	-	-	PUNCT
dti-1318	151	8	ca	can	AUX
dti-1318	151	9	not	not	PART
dti-1318	151	10	only	only	ADV
dti-1318	151	11	affects	affect	VERB
dti-1318	151	12	the	the	DET
dti-1318	151	13	assembly	assembly	NOUN
dti-1318	151	14	of	of	ADP
dti-1318	151	15	the	the	DET
dti-1318	151	16	immature	immature	ADJ
dti-1318	151	17	capsid	capsid	ADJ
dti-1318	151	18	particles	particle	NOUN
dti-1318	151	19	but	but	CCONJ
dti-1318	151	20	also	also	ADV
dti-1318	151	21	reduces	reduce	VERB
dti-1318	151	22	the	the	DET
dti-1318	151	23	amount	amount	NOUN
dti-1318	151	24	of	of	ADP
dti-1318	151	25	correctly	correctly	ADV
dti-1318	151	26	assembled	assemble	VERB
dti-1318	151	27	mature	mature	ADJ
dti-1318	151	28	capsids	capsid	NOUN
dti-1318	151	29	in	in	ADP
dti-1318	151	30	vitro	vitro	X
dti-1318	151	31	,	,	PUNCT
dti-1318	151	32	thus	thus	ADV
dti-1318	151	33	acting	act	VERB
dti-1318	151	34	as	as	ADP
dti-1318	151	35	a	a	DET
dti-1318	151	36	promising	promising	ADJ
dti-1318	151	37	two	two	NUM
dti-1318	151	38	-	-	PUNCT
dti-1318	151	39	step	step	NOUN
dti-1318	151	40	inhibitor	inhibitor	NOUN
dti-1318	151	41	(	(	PUNCT
dti-1318	151	42	sticht	sticht	PROPN
dti-1318	151	43	et	et	PROPN
dti-1318	151	44	al	al	PROPN
dti-1318	151	45	.	.	PROPN
dti-1318	151	46	2005	2005	NUM
dti-1318	151	47	)	)	PUNCT
dti-1318	151	48	.	.	PUNCT
dti-1318	152	1	the	the	DET
dti-1318	152	2	c	c	NOUN
dti-1318	152	3	-	-	PUNCT
dti-1318	152	4	terminal	terminal	ADJ
dti-1318	152	5	domain	domain	NOUN
dti-1318	152	6	of	of	ADP
dti-1318	152	7	gag	gag	NOUN
dti-1318	152	8	in	in	ADP
dti-1318	152	9	the	the	DET
dti-1318	152	10	context	context	NOUN
dti-1318	152	11	of	of	ADP
dti-1318	152	12	gag	gag	NOUN
dti-1318	152	13	-	-	PUNCT
dti-1318	152	14	pol	pol	NOUN
dti-1318	152	15	is	be	AUX
dti-1318	152	16	essential	essential	ADJ
dti-1318	152	17	for	for	ADP
dti-1318	152	18	its	its	PRON
dti-1318	152	19	interaction	interaction	NOUN
dti-1318	152	20	with	with	ADP
dti-1318	152	21	gag	gag	NOUN
dti-1318	152	22	and	and	CCONJ
dti-1318	152	23	its	its	PRON
dti-1318	152	24	incorporation	incorporation	NOUN
dti-1318	152	25	into	into	ADP
dti-1318	152	26	the	the	DET
dti-1318	152	27	virion	virion	NOUN
dti-1318	152	28	(	(	PUNCT
dti-1318	152	29	srinivasakumar	srinivasakumar	PROPN
dti-1318	152	30	et	et	PROPN
dti-1318	152	31	al	al	PROPN
dti-1318	152	32	.	.	PROPN
dti-1318	152	33	1995	1995	NUM
dti-1318	152	34	;	;	PUNCT
dti-1318	153	1	chiu	chiu	PROPN
dti-1318	153	2	et	et	PROPN
dti-1318	153	3	al	al	PROPN
dti-1318	153	4	.	.	PROPN
dti-1318	153	5	2002	2002	NUM
dti-1318	153	6	;	;	PUNCT
dti-1318	153	7	chien	chien	PROPN
dti-1318	153	8	et	et	PROPN
dti-1318	153	9	al	al	PROPN
dti-1318	153	10	.	.	PROPN
dti-1318	153	11	2006	2006	NUM
dti-1318	153	12	)	)	PUNCT
dti-1318	153	13	.	.	PUNCT
dti-1318	154	1	this	this	DET
dti-1318	154	2	sequence	sequence	NOUN
dti-1318	154	3	includes	include	VERB
dti-1318	154	4	a	a	DET
dti-1318	154	5	highly	highly	ADV
dti-1318	154	6	conserved	conserve	VERB
dti-1318	154	7	“	"	PUNCT
dti-1318	154	8	major	major	ADJ
dti-1318	154	9	homology	homology	NOUN
dti-1318	154	10	region	region	NOUN
dti-1318	154	11	”	"	PUNCT
dti-1318	154	12	(	(	PUNCT
dti-1318	154	13	mhr	mhr	PROPN
dti-1318	154	14	)	)	PUNCT
dti-1318	154	15	in	in	ADP
dti-1318	154	16	the	the	DET
dti-1318	154	17	ca	ca	NOUN
dti-1318	154	18	domain	domain	NOUN
dti-1318	154	19	of	of	ADP
dti-1318	154	20	gag	gag	NOUN
dti-1318	154	21	and	and	CCONJ
dti-1318	154	22	the	the	DET
dti-1318	154	23	adjacent	adjacent	ADJ
dti-1318	154	24	ca	ca	NOUN
dti-1318	154	25	-	-	PUNCT
dti-1318	154	26	sp1	sp1	NOUN
dti-1318	154	27	(	(	PUNCT
dti-1318	154	28	srinivasakumar	srinivasakumar	PROPN
dti-1318	154	29	et	et	PROPN
dti-1318	154	30	al	al	PROPN
dti-1318	154	31	.	.	PROPN
dti-1318	154	32	1995	1995	NUM
dti-1318	154	33	;	;	PUNCT
dti-1318	154	34	chien	chien	PROPN
dti-1318	154	35	et	et	PROPN
dti-1318	154	36	al	al	PROPN
dti-1318	154	37	.	.	PROPN
dti-1318	154	38	2006	2006	NUM
dti-1318	154	39	)	)	PUNCT
dti-1318	154	40	.	.	PUNCT
dti-1318	155	1	these	these	DET
dti-1318	155	2	sequences	sequence	NOUN
dti-1318	155	3	are	be	AUX
dti-1318	155	4	also	also	ADV
dti-1318	155	5	critical	critical	ADJ
dti-1318	155	6	for	for	ADP
dti-1318	155	7	hiv-1	hiv-1	VERB
dti-1318	155	8	gag	gag	NOUN
dti-1318	155	9	assembly	assembly	NOUN
dti-1318	155	10	as	as	SCONJ
dti-1318	155	11	they	they	PRON
dti-1318	155	12	drive	drive	VERB
dti-1318	155	13	gag	gag	NOUN
dti-1318	155	14	oligomerization	oligomerization	NOUN
dti-1318	155	15	.	.	PUNCT
dti-1318	156	1	however	however	ADV
dti-1318	156	2	,	,	PUNCT
dti-1318	156	3	the	the	DET
dti-1318	156	4	magnitude	magnitude	NOUN
dti-1318	156	5	of	of	ADP
dti-1318	156	6	the	the	DET
dti-1318	156	7	virion	virion	NOUN
dti-1318	156	8	incorporation	incorporation	NOUN
dti-1318	156	9	defect	defect	NOUN
dti-1318	156	10	of	of	ADP
dti-1318	156	11	gag	gag	NOUN
dti-1318	156	12	-	-	PUNCT
dti-1318	156	13	pol	pol	NOUN
dti-1318	156	14	mhr	mhr	PROPN
dti-1318	156	15	deletion	deletion	NOUN
dti-1318	156	16	mutants	mutant	NOUN
dti-1318	156	17	varies	vary	VERB
dti-1318	156	18	between	between	ADP
dti-1318	156	19	different	different	ADJ
dti-1318	156	20	studies	study	NOUN
dti-1318	156	21	making	make	VERB
dti-1318	156	22	the	the	DET
dti-1318	156	23	value	value	NOUN
dti-1318	156	24	of	of	ADP
dti-1318	156	25	targeting	target	VERB
dti-1318	156	26	this	this	DET
dti-1318	156	27	region	region	NOUN
dti-1318	156	28	of	of	ADP
dti-1318	156	29	gag	gag	NOUN
dti-1318	156	30	-	-	PUNCT
dti-1318	156	31	pol	pol	NOUN
dti-1318	156	32	unclear	unclear	ADJ
dti-1318	156	33	with	with	ADP
dti-1318	156	34	respect	respect	NOUN
dti-1318	156	35	to	to	ADP
dti-1318	156	36	inhibition	inhibition	NOUN
dti-1318	156	37	of	of	ADP
dti-1318	156	38	the	the	DET
dti-1318	156	39	late	late	ADJ
dti-1318	156	40	stages	stage	NOUN
dti-1318	156	41	of	of	ADP
dti-1318	156	42	hiv-1	hiv-1	X
dti-1318	156	43	replication	replication	NOUN
dti-1318	156	44	(	(	PUNCT
dti-1318	156	45	mammano	mammano	NOUN
dti-1318	156	46	et	et	PROPN
dti-1318	156	47	al	al	PROPN
dti-1318	156	48	.	.	PROPN
dti-1318	156	49	1994	1994	NUM
dti-1318	156	50	;	;	PUNCT
dti-1318	156	51	srinivasakumar	srinivasakumar	PROPN
dti-1318	156	52	et	et	PROPN
dti-1318	156	53	al	al	PROPN
dti-1318	156	54	.	.	PROPN
dti-1318	156	55	1995	1995	NUM
dti-1318	156	56	;	;	PUNCT
dti-1318	156	57	chiu	chiu	PROPN
dti-1318	156	58	et	et	PROPN
dti-1318	156	59	al	al	PROPN
dti-1318	156	60	.	.	PROPN
dti-1318	156	61	2002	2002	NUM
dti-1318	156	62	;	;	PUNCT
dti-1318	156	63	chien	chien	PROPN
dti-1318	156	64	et	et	PROPN
dti-1318	156	65	al	al	PROPN
dti-1318	156	66	.	.	PROPN
dti-1318	156	67	2006	2006	NUM
dti-1318	156	68	)	)	PUNCT
dti-1318	156	69	.	.	PUNCT
dti-1318	157	1	sequences	sequence	NOUN
dti-1318	157	2	involved	involve	VERB
dti-1318	157	3	in	in	ADP
dti-1318	157	4	gag	gag	NOUN
dti-1318	157	5	and	and	CCONJ
dti-1318	157	6	gag	gag	NOUN
dti-1318	157	7	-	-	PUNCT
dti-1318	157	8	pol	pol	NOUN
dti-1318	157	9	interactions	interaction	NOUN
dti-1318	157	10	are	be	AUX
dti-1318	157	11	assumed	assume	VERB
dti-1318	157	12	to	to	PART
dti-1318	157	13	be	be	AUX
dti-1318	157	14	similar	similar	ADJ
dti-1318	157	15	to	to	ADP
dti-1318	157	16	those	those	PRON
dti-1318	157	17	involved	involve	VERB
dti-1318	157	18	in	in	ADP
dti-1318	157	19	gag	gag	NOUN
dti-1318	157	20	-	-	PUNCT
dti-1318	157	21	gag	gag	NOUN
dti-1318	157	22	interactions	interaction	NOUN
dti-1318	157	23	.	.	PUNCT
dti-1318	158	1	however	however	ADV
dti-1318	158	2	,	,	PUNCT
dti-1318	158	3	virions	virion	NOUN
dti-1318	158	4	generated	generate	VERB
dti-1318	158	5	in	in	ADP
dti-1318	158	6	the	the	DET
dti-1318	158	7	presence	presence	NOUN
dti-1318	158	8	of	of	ADP
dti-1318	158	9	cap-1	cap-1	VERB
dti-1318	158	10	are	be	AUX
dti-1318	158	11	unlikely	unlikely	ADJ
dti-1318	158	12	to	to	PART
dti-1318	158	13	affect	affect	VERB
dti-1318	158	14	gag	gag	NOUN
dti-1318	158	15	/	/	SYM
dti-1318	158	16	gag	gag	NOUN
dti-1318	158	17	-	-	PUNCT
dti-1318	158	18	pol	pol	NOUN
dti-1318	158	19	interactions	interaction	NOUN
dti-1318	158	20	as	as	ADP
dti-1318	158	21	defects	defect	NOUN
dti-1318	158	22	in	in	ADP
dti-1318	158	23	proteolytic	proteolytic	ADJ
dti-1318	158	24	processing	processing	NOUN
dti-1318	158	25	in	in	ADP
dti-1318	158	26	the	the	DET
dti-1318	158	27	virus	virus	NOUN
dti-1318	158	28	or	or	CCONJ
dti-1318	158	29	virion	virion	NOUN
dti-1318	158	30	associated	associate	VERB
dti-1318	158	31	rt	rt	PROPN
dti-1318	158	32	activity	activity	NOUN
dti-1318	158	33	were	be	AUX
dti-1318	158	34	not	not	PART
dti-1318	158	35	observed	observe	VERB
dti-1318	158	36	(	(	PUNCT
dti-1318	158	37	tang	tang	X
dti-1318	158	38	et	et	PROPN
dti-1318	158	39	al	al	PROPN
dti-1318	158	40	.	.	PROPN
dti-1318	158	41	2003	2003	NUM
dti-1318	158	42	)	)	PUNCT
dti-1318	158	43	.	.	PUNCT
dti-1318	159	1	the	the	DET
dti-1318	159	2	proline	proline	NOUN
dti-1318	159	3	rich	rich	ADJ
dti-1318	159	4	region	region	NOUN
dti-1318	159	5	of	of	ADP
dti-1318	159	6	p6	p6	PROPN
dti-1318	159	7	has	have	AUX
dti-1318	159	8	also	also	ADV
dti-1318	159	9	been	be	AUX
dti-1318	159	10	implicated	implicate	VERB
dti-1318	159	11	in	in	ADP
dti-1318	159	12	the	the	DET
dti-1318	159	13	packaging	packaging	NOUN
dti-1318	159	14	of	of	ADP
dti-1318	159	15	cleaved	cleaved	ADJ
dti-1318	159	16	pol	pol	NOUN
dti-1318	159	17	proteins	protein	NOUN
dti-1318	159	18	into	into	ADP
dti-1318	159	19	virions	virion	NOUN
dti-1318	159	20	,	,	PUNCT
dti-1318	159	21	which	which	PRON
dti-1318	159	22	is	be	AUX
dti-1318	159	23	suggested	suggest	VERB
dti-1318	159	24	to	to	PART
dti-1318	159	25	be	be	AUX
dti-1318	159	26	mediated	mediate	VERB
dti-1318	159	27	by	by	ADP
dti-1318	159	28	host	host	NOUN
dti-1318	159	29	cell	cell	NOUN
dti-1318	159	30	proteins	protein	NOUN
dti-1318	159	31	(	(	PUNCT
dti-1318	159	32	dettenhofer	dettenhofer	NOUN
dti-1318	159	33	and	and	CCONJ
dti-1318	159	34	yu	yu	PROPN
dti-1318	159	35	,	,	PUNCT
dti-1318	159	36	1999	1999	NUM
dti-1318	159	37	;	;	PUNCT
dti-1318	159	38	cen	cen	PROPN
dti-1318	159	39	et	et	PROPN
dti-1318	159	40	al	al	PROPN
dti-1318	159	41	.	.	PROPN
dti-1318	159	42	2004	2004	NUM
dti-1318	159	43	)	)	PUNCT
dti-1318	159	44	.	.	PUNCT
dti-1318	160	1	identifying	identify	VERB
dti-1318	160	2	the	the	DET
dti-1318	160	3	host	host	NOUN
dti-1318	160	4	cell	cell	NOUN
dti-1318	160	5	factor	factor	NOUN
dti-1318	160	6	implicated	implicate	VERB
dti-1318	160	7	in	in	ADP
dti-1318	160	8	the	the	DET
dti-1318	160	9	virion	virion	NOUN
dti-1318	160	10	incorporation	incorporation	NOUN
dti-1318	160	11	of	of	ADP
dti-1318	160	12	cleaved	cleaved	ADJ
dti-1318	160	13	pol	pol	NOUN
dti-1318	160	14	will	will	AUX
dti-1318	160	15	be	be	AUX
dti-1318	160	16	necessary	necessary	ADJ
dti-1318	160	17	for	for	ADP
dti-1318	160	18	establishing	establish	VERB
dti-1318	160	19	this	this	DET
dti-1318	160	20	process	process	NOUN
dti-1318	160	21	as	as	ADP
dti-1318	160	22	a	a	DET
dti-1318	160	23	viable	viable	ADJ
dti-1318	160	24	drug	drug	NOUN
dti-1318	160	25	target	target	NOUN
dti-1318	160	26	.	.	PUNCT
dti-1318	161	1	targeting	target	VERB
dti-1318	161	2	hiv-1	hiv-1	X
dti-1318	161	3	nc	nc	VERB
dti-1318	161	4	the	the	PRON
dti-1318	161	5	hiv-1	hiv-1	X
dti-1318	161	6	nc	nc	PROPN
dti-1318	161	7	(	(	PUNCT
dti-1318	161	8	ncp7	ncp7	PROPN
dti-1318	161	9	)	)	PUNCT
dti-1318	161	10	contains	contain	VERB
dti-1318	161	11	two	two	NUM
dti-1318	161	12	highly	highly	ADV
dti-1318	161	13	conserved	conserve	VERB
dti-1318	161	14	zinc	zinc	NOUN
dti-1318	161	15	fi	fi	NOUN
dti-1318	161	16	nger	nger	ADJ
dti-1318	161	17	motifs	motifs	NOUN
dti-1318	161	18	c	c	NOUN
dti-1318	161	19	-	-	PUNCT
dti-1318	161	20	x2	x2	ADJ
dti-1318	161	21	-	-	PUNCT
dti-1318	161	22	c	c	NOUN
dti-1318	161	23	-	-	PUNCT
dti-1318	161	24	x4	x4	VERB
dti-1318	161	25	-	-	PROPN
dti-1318	161	26	h	h	NOUN
dti-1318	161	27	-	-	PUNCT
dti-1318	161	28	x4	x4	PROPN
dti-1318	161	29	-	-	PROPN
dti-1318	161	30	c	c	PROPN
dti-1318	161	31	(	(	PUNCT
dti-1318	161	32	x	x	X
dti-1318	161	33	,	,	PUNCT
dti-1318	161	34	any	any	DET
dti-1318	161	35	amino	amino	NOUN
dti-1318	161	36	acid	acid	NOUN
dti-1318	161	37	)	)	PUNCT
dti-1318	161	38	.	.	PUNCT
dti-1318	162	1	the	the	DET
dti-1318	162	2	zinc	zinc	NOUN
dti-1318	162	3	fi	fi	NOUN
dti-1318	162	4	ngers	nger	NOUN
dti-1318	162	5	of	of	ADP
dti-1318	162	6	nc	nc	PROPN
dti-1318	162	7	are	be	AUX
dti-1318	162	8	critical	critical	ADJ
dti-1318	162	9	in	in	ADP
dti-1318	162	10	the	the	DET
dti-1318	162	11	early	early	ADJ
dti-1318	162	12	and	and	CCONJ
dti-1318	162	13	late	late	ADJ
dti-1318	162	14	stages	stage	NOUN
dti-1318	162	15	of	of	ADP
dti-1318	162	16	hiv-1	hiv-1	X
dti-1318	162	17	replication	replication	NOUN
dti-1318	162	18	with	with	ADP
dti-1318	162	19	mutations	mutation	NOUN
dti-1318	162	20	in	in	ADP
dti-1318	162	21	the	the	DET
dti-1318	162	22	zinc	zinc	NOUN
dti-1318	162	23	chelating	chelating	NOUN
dti-1318	162	24	amino	amino	ADJ
dti-1318	162	25	acids	acid	NOUN
dti-1318	162	26	resulting	result	VERB
dti-1318	162	27	in	in	ADP
dti-1318	162	28	formation	formation	NOUN
dti-1318	162	29	of	of	ADP
dti-1318	162	30	noninfectious	noninfectious	ADJ
dti-1318	162	31	virus	virus	NOUN
dti-1318	162	32	(	(	PUNCT
dti-1318	162	33	aldovini	aldovini	PROPN
dti-1318	162	34	and	and	CCONJ
dti-1318	162	35	young	young	ADJ
dti-1318	162	36	,	,	PUNCT
dti-1318	162	37	1990	1990	NUM
dti-1318	162	38	)	)	PUNCT
dti-1318	162	39	.	.	PUNCT
dti-1318	163	1	the	the	DET
dti-1318	163	2	zinc	zinc	NOUN
dti-1318	163	3	fi	fi	NOUN
dti-1318	163	4	ngers	nger	NOUN
dti-1318	163	5	of	of	ADP
dti-1318	163	6	ncp7	ncp7	PROPN
dti-1318	163	7	are	be	AUX
dti-1318	163	8	required	require	VERB
dti-1318	163	9	for	for	ADP
dti-1318	163	10	initiation	initiation	NOUN
dti-1318	163	11	,	,	PUNCT
dti-1318	163	12	elongation	elongation	NOUN
dti-1318	163	13	and	and	CCONJ
dti-1318	163	14	effi	effi	PROPN
dti-1318	163	15	cient	cient	NOUN
dti-1318	163	16	template	template	NOUN
dti-1318	163	17	switching	switch	VERB
dti-1318	163	18	during	during	ADP
dti-1318	163	19	reverse	reverse	ADJ
dti-1318	163	20	transcription	transcription	NOUN
dti-1318	163	21	(	(	PUNCT
dti-1318	163	22	rodriguezrodriguez	rodriguezrodriguez	NOUN
dti-1318	163	23	et	et	PROPN
dti-1318	163	24	al	al	PROPN
dti-1318	163	25	.	.	PROPN
dti-1318	163	26	1995	1995	NUM
dti-1318	163	27	;	;	PUNCT
dti-1318	164	1	tanchou	tanchou	NOUN
dti-1318	164	2	et	et	PROPN
dti-1318	164	3	al	al	PROPN
dti-1318	164	4	.	.	PROPN
dti-1318	164	5	1995	1995	NUM
dti-1318	164	6	)	)	PUNCT
dti-1318	164	7	.	.	PUNCT
dti-1318	165	1	ncp7	ncp7	PROPN
dti-1318	165	2	is	be	AUX
dti-1318	165	3	also	also	ADV
dti-1318	165	4	involved	involve	VERB
dti-1318	165	5	in	in	ADP
dti-1318	165	6	hiv-1	hiv-1	PUNCT
dti-1318	165	7	genomic	genomic	ADJ
dti-1318	165	8	rna	rna	NOUN
dti-1318	165	9	dimerization	dimerization	NOUN
dti-1318	165	10	,	,	PUNCT
dti-1318	165	11	in	in	ADP
dti-1318	165	12	cleavage	cleavage	NOUN
dti-1318	165	13	activity	activity	NOUN
dti-1318	165	14	and	and	CCONJ
dti-1318	165	15	coats	coat	VERB
dti-1318	165	16	the	the	DET
dti-1318	165	17	viral	viral	ADJ
dti-1318	165	18	rna	rna	NOUN
dti-1318	165	19	genome	genome	NOUN
dti-1318	165	20	protecting	protect	VERB
dti-1318	165	21	it	it	PRON
dti-1318	165	22	from	from	ADP
dti-1318	165	23	nucleases	nuclease	NOUN
dti-1318	165	24	(	(	PUNCT
dti-1318	165	25	lapadat	lapadat	ADJ
dti-1318	165	26	-	-	PUNCT
dti-1318	165	27	tapolsky	tapolsky	NOUN
dti-1318	165	28	et	et	PROPN
dti-1318	165	29	al	al	PROPN
dti-1318	165	30	.	.	PROPN
dti-1318	165	31	1993	1993	NUM
dti-1318	165	32	)	)	PUNCT
dti-1318	165	33	.	.	PUNCT
dti-1318	166	1	given	give	VERB
dti-1318	166	2	the	the	DET
dti-1318	166	3	critical	critical	ADJ
dti-1318	166	4	role	role	NOUN
dti-1318	166	5	of	of	ADP
dti-1318	166	6	ncp7	ncp7	PROPN
dti-1318	166	7	zinc	zinc	NOUN
dti-1318	166	8	fi	fi	NOUN
dti-1318	166	9	ngers	nger	NOUN
dti-1318	166	10	in	in	ADP
dti-1318	166	11	hiv-1	hiv-1	X
dti-1318	166	12	replication	replication	NOUN
dti-1318	166	13	it	it	PRON
dti-1318	166	14	is	be	AUX
dti-1318	166	15	not	not	PART
dti-1318	166	16	surprising	surprising	ADJ
dti-1318	166	17	that	that	SCONJ
dti-1318	166	18	agents	agent	NOUN
dti-1318	166	19	that	that	PRON
dti-1318	166	20	covalently	covalently	ADV
dti-1318	166	21	modify	modify	VERB
dti-1318	166	22	the	the	DET
dti-1318	166	23	zinc	zinc	NOUN
dti-1318	166	24	chelating	chelating	NOUN
dti-1318	166	25	residues	residue	NOUN
dti-1318	166	26	of	of	ADP
dti-1318	166	27	ncp7	ncp7	PROPN
dti-1318	166	28	have	have	AUX
dti-1318	166	29	been	be	AUX
dti-1318	166	30	described	describe	VERB
dti-1318	166	31	as	as	ADP
dti-1318	166	32	inhibitors	inhibitor	NOUN
dti-1318	166	33	of	of	ADP
dti-1318	166	34	hiv-1	hiv-1	X
dti-1318	166	35	replication	replication	NOUN
dti-1318	166	36	(	(	PUNCT
dti-1318	166	37	rice	rice	NOUN
dti-1318	166	38	et	et	PROPN
dti-1318	166	39	al	al	PROPN
dti-1318	166	40	.	.	PROPN
dti-1318	166	41	1995	1995	NUM
dti-1318	166	42	)	)	PUNCT
dti-1318	166	43	.	.	PUNCT
dti-1318	167	1	the	the	DET
dti-1318	167	2	electrophilic	electrophilic	ADJ
dti-1318	167	3	167	167	NUM
dti-1318	167	4	targeting	target	VERB
dti-1318	167	5	the	the	DET
dti-1318	167	6	late	late	ADJ
dti-1318	167	7	stages	stage	NOUN
dti-1318	167	8	of	of	ADP
dti-1318	167	9	hiv-1	hiv-1	X
dti-1318	167	10	replication	replication	NOUN
dti-1318	167	11	drug	drug	NOUN
dti-1318	167	12	target	target	NOUN
dti-1318	167	13	insights	insight	NOUN
dti-1318	167	14	2007	2007	NUM
dti-1318	167	15	:	:	PUNCT
dti-1318	167	16	2	2	NUM
dti-1318	167	17	disulfi	disulfi	ADJ
dti-1318	167	18	de	de	ADJ
dti-1318	167	19	-	-	ADJ
dti-1318	167	20	substituted	substitute	VERB
dti-1318	167	21	benzamides	benzamide	NOUN
dti-1318	167	22	(	(	PUNCT
dti-1318	167	23	dibas	dibas	PROPN
dti-1318	167	24	)	)	PUNCT
dti-1318	167	25	inactivate	inactivate	NOUN
dti-1318	167	26	cell	cell	NOUN
dti-1318	167	27	free	free	ADJ
dti-1318	167	28	virus	virus	NOUN
dti-1318	167	29	and	and	CCONJ
dti-1318	167	30	inhibit	inhibit	VERB
dti-1318	167	31	the	the	DET
dti-1318	167	32	early	early	ADJ
dti-1318	167	33	and	and	CCONJ
dti-1318	167	34	late	late	ADJ
dti-1318	167	35	stages	stage	NOUN
dti-1318	167	36	of	of	ADP
dti-1318	167	37	hiv-1	hiv-1	X
dti-1318	167	38	replication	replication	NOUN
dti-1318	167	39	by	by	ADP
dti-1318	167	40	interfering	interfere	VERB
dti-1318	167	41	with	with	ADP
dti-1318	167	42	reverse	reverse	ADJ
dti-1318	167	43	transcription	transcription	NOUN
dti-1318	167	44	and	and	CCONJ
dti-1318	167	45	viral	viral	ADJ
dti-1318	167	46	particle	particle	NOUN
dti-1318	167	47	maturation	maturation	NOUN
dti-1318	167	48	(	(	PUNCT
dti-1318	167	49	rice	rice	NOUN
dti-1318	167	50	et	et	PROPN
dti-1318	167	51	al	al	PROPN
dti-1318	167	52	.	.	PROPN
dti-1318	167	53	1995	1995	NUM
dti-1318	167	54	;	;	PUNCT
dti-1318	167	55	turpin	turpin	NOUN
dti-1318	167	56	et	et	PROPN
dti-1318	167	57	al	al	PROPN
dti-1318	167	58	.	.	PROPN
dti-1318	167	59	1996	1996	NUM
dti-1318	167	60	)	)	PUNCT
dti-1318	167	61	.	.	PUNCT
dti-1318	168	1	in	in	ADP
dti-1318	168	2	the	the	DET
dti-1318	168	3	u1	u1	NOUN
dti-1318	168	4	cell	cell	NOUN
dti-1318	168	5	line	line	NOUN
dti-1318	168	6	treatment	treatment	NOUN
dti-1318	168	7	with	with	ADP
dti-1318	168	8	dibas	dibas	NOUN
dti-1318	168	9	results	result	NOUN
dti-1318	168	10	in	in	ADP
dti-1318	168	11	the	the	DET
dti-1318	168	12	inhibition	inhibition	NOUN
dti-1318	168	13	of	of	ADP
dti-1318	168	14	virus	virus	NOUN
dti-1318	168	15	particle	particle	NOUN
dti-1318	168	16	release	release	NOUN
dti-1318	168	17	,	,	PUNCT
dti-1318	168	18	processing	processing	NOUN
dti-1318	168	19	of	of	ADP
dti-1318	168	20	gag	gag	NOUN
dti-1318	168	21	,	,	PUNCT
dti-1318	168	22	and	and	CCONJ
dti-1318	168	23	the	the	DET
dti-1318	168	24	production	production	NOUN
dti-1318	168	25	of	of	ADP
dti-1318	168	26	virions	virion	NOUN
dti-1318	168	27	with	with	ADP
dti-1318	168	28	reduced	reduced	ADJ
dti-1318	168	29	infectivity	infectivity	NOUN
dti-1318	168	30	(	(	PUNCT
dti-1318	168	31	turpin	turpin	NOUN
dti-1318	168	32	et	et	PROPN
dti-1318	168	33	al	al	PROPN
dti-1318	168	34	.	.	PROPN
dti-1318	168	35	1996	1996	NUM
dti-1318	168	36	)	)	PUNCT
dti-1318	168	37	.	.	PUNCT
dti-1318	169	1	the	the	DET
dti-1318	169	2	defect	defect	NOUN
dti-1318	169	3	in	in	ADP
dti-1318	169	4	viral	viral	ADJ
dti-1318	169	5	particle	particle	NOUN
dti-1318	169	6	release	release	NOUN
dti-1318	169	7	and	and	CCONJ
dti-1318	169	8	maturation	maturation	NOUN
dti-1318	169	9	was	be	AUX
dti-1318	169	10	attributed	attribute	VERB
dti-1318	169	11	to	to	ADP
dti-1318	169	12	the	the	DET
dti-1318	169	13	formation	formation	NOUN
dti-1318	169	14	of	of	ADP
dti-1318	169	15	intermolecular	intermolecular	ADJ
dti-1318	169	16	cross	cross	NOUN
dti-1318	169	17	-	-	NOUN
dti-1318	169	18	linkages	linkage	NOUN
dti-1318	169	19	between	between	ADP
dti-1318	169	20	the	the	DET
dti-1318	169	21	zinc	zinc	NOUN
dti-1318	169	22	fi	fi	NOUN
dti-1318	169	23	ngers	nger	NOUN
dti-1318	169	24	of	of	ADP
dti-1318	169	25	adjacent	adjacent	ADJ
dti-1318	169	26	gag	gag	NOUN
dti-1318	169	27	molecules	molecule	NOUN
dti-1318	169	28	,	,	PUNCT
dti-1318	169	29	thereby	thereby	ADV
dti-1318	169	30	preventing	prevent	VERB
dti-1318	169	31	effi	effi	PROPN
dti-1318	169	32	cient	cient	NOUN
dti-1318	169	33	cleavage	cleavage	NOUN
dti-1318	169	34	by	by	ADP
dti-1318	169	35	the	the	DET
dti-1318	169	36	hiv-1	hiv-1	ADJ
dti-1318	169	37	pr	pr	NOUN
dti-1318	169	38	(	(	PUNCT
dti-1318	169	39	turpin	turpin	PROPN
dti-1318	169	40	et	et	PROPN
dti-1318	169	41	al	al	PROPN
dti-1318	169	42	.	.	PROPN
dti-1318	169	43	1996	1996	NUM
dti-1318	169	44	)	)	PUNCT
dti-1318	169	45	.	.	PUNCT
dti-1318	170	1	the	the	DET
dti-1318	170	2	non	non	ADJ
dti-1318	170	3	-	-	ADJ
dti-1318	170	4	dissociable	dissociable	ADJ
dti-1318	170	5	tethered	tethered	ADJ
dti-1318	170	6	dithiane	dithiane	NOUN
dti-1318	170	7	compound	compound	NOUN
dti-1318	170	8	1,2	1,2	NUM
dti-1318	170	9	-	-	PUNCT
dti-1318	170	10	dithiane-4,5	dithiane-4,5	VERB
dti-1318	170	11	-	-	PUNCT
dti-1318	170	12	diol,1,1	diol,1,1	NOUN
dti-1318	170	13	-	-	PUNCT
dti-1318	170	14	dioxide	dioxide	NOUN
dti-1318	170	15	,	,	PUNCT
dti-1318	170	16	(	(	PUNCT
dti-1318	170	17	nsc	nsc	PROPN
dti-1318	170	18	624151	624151	NUM
dti-1318	170	19	)	)	PUNCT
dti-1318	170	20	also	also	ADV
dti-1318	170	21	mediates	mediate	VERB
dti-1318	170	22	similar	similar	ADJ
dti-1318	170	23	defects	defect	NOUN
dti-1318	170	24	in	in	ADP
dti-1318	170	25	gag	gag	NOUN
dti-1318	170	26	processing	processing	NOUN
dti-1318	170	27	(	(	PUNCT
dti-1318	170	28	rice	rice	NOUN
dti-1318	170	29	et	et	PROPN
dti-1318	170	30	al	al	PROPN
dti-1318	170	31	.	.	PROPN
dti-1318	170	32	1997	1997	NUM
dti-1318	170	33	)	)	PUNCT
dti-1318	170	34	.	.	PUNCT
dti-1318	171	1	although	although	SCONJ
dti-1318	171	2	cellular	cellular	ADJ
dti-1318	171	3	proteins	protein	NOUN
dti-1318	171	4	also	also	ADV
dti-1318	171	5	contain	contain	VERB
dti-1318	171	6	zinc	zinc	NOUN
dti-1318	171	7	fingers	finger	NOUN
dti-1318	171	8	,	,	PUNCT
dti-1318	171	9	these	these	DET
dti-1318	171	10	inhibitors	inhibitor	NOUN
dti-1318	171	11	appear	appear	VERB
dti-1318	171	12	to	to	PART
dti-1318	171	13	preferentially	preferentially	ADV
dti-1318	171	14	target	target	VERB
dti-1318	171	15	retroviral	retroviral	ADJ
dti-1318	171	16	zinc	zinc	NOUN
dti-1318	171	17	fingers	finger	NOUN
dti-1318	171	18	.	.	PUNCT
dti-1318	172	1	this	this	PRON
dti-1318	172	2	may	may	AUX
dti-1318	172	3	be	be	AUX
dti-1318	172	4	explained	explain	VERB
dti-1318	172	5	by	by	ADP
dti-1318	172	6	the	the	DET
dti-1318	172	7	inaccessibility	inaccessibility	NOUN
dti-1318	172	8	of	of	ADP
dti-1318	172	9	these	these	DET
dti-1318	172	10	inhibitors	inhibitor	NOUN
dti-1318	172	11	to	to	ADP
dti-1318	172	12	the	the	DET
dti-1318	172	13	appropriate	appropriate	ADJ
dti-1318	172	14	cellular	cellular	ADJ
dti-1318	172	15	compartments	compartment	NOUN
dti-1318	172	16	where	where	SCONJ
dti-1318	172	17	zinc	zinc	NOUN
dti-1318	172	18	finger	finger	NOUN
dti-1318	172	19	containing	contain	VERB
dti-1318	172	20	cellular	cellular	ADJ
dti-1318	172	21	proteins	protein	NOUN
dti-1318	172	22	are	be	AUX
dti-1318	172	23	located	locate	VERB
dti-1318	172	24	.	.	PUNCT
dti-1318	173	1	the	the	DET
dti-1318	173	2	in	in	ADP
dti-1318	173	3	vivo	vivo	ADJ
dti-1318	173	4	anti	anti	ADJ
dti-1318	173	5	-	-	ADJ
dti-1318	173	6	hiv-1	hiv-1	ADJ
dti-1318	173	7	activity	activity	NOUN
dti-1318	173	8	of	of	ADP
dti-1318	173	9	zinc	zinc	NOUN
dti-1318	173	10	finger	finger	NOUN
dti-1318	173	11	inhibitors	inhibitor	NOUN
dti-1318	173	12	has	have	AUX
dti-1318	173	13	been	be	AUX
dti-1318	173	14	demonstrated	demonstrate	VERB
dti-1318	173	15	in	in	ADP
dti-1318	173	16	a	a	DET
dti-1318	173	17	transgenic	transgenic	NOUN
dti-1318	173	18	murine	murine	ADJ
dti-1318	173	19	model	model	NOUN
dti-1318	173	20	where	where	SCONJ
dti-1318	173	21	infectious	infectious	ADJ
dti-1318	173	22	hiv-1	hiv-1	X
dti-1318	173	23	is	be	AUX
dti-1318	173	24	induced	induce	VERB
dti-1318	173	25	from	from	ADP
dti-1318	173	26	an	an	DET
dti-1318	173	27	integrated	integrate	VERB
dti-1318	173	28	provirus	provirus	NOUN
dti-1318	173	29	(	(	PUNCT
dti-1318	173	30	schito	schito	PROPN
dti-1318	173	31	et	et	PROPN
dti-1318	173	32	al	al	PROPN
dti-1318	173	33	.	.	PROPN
dti-1318	173	34	2003	2003	NUM
dti-1318	173	35	)	)	PUNCT
dti-1318	173	36	.	.	PUNCT
dti-1318	174	1	a	a	DET
dti-1318	174	2	recent	recent	ADJ
dti-1318	174	3	study	study	NOUN
dti-1318	174	4	in	in	ADP
dti-1318	174	5	a	a	DET
dti-1318	174	6	nonhuman	nonhuman	ADJ
dti-1318	174	7	primate	primate	NOUN
dti-1318	174	8	model	model	NOUN
dti-1318	174	9	demonstrated	demonstrate	VERB
dti-1318	174	10	a	a	DET
dti-1318	174	11	reduction	reduction	NOUN
dti-1318	174	12	in	in	ADP
dti-1318	174	13	the	the	DET
dti-1318	174	14	levels	level	NOUN
dti-1318	174	15	of	of	ADP
dti-1318	174	16	siv/	siv/	ADJ
dti-1318	174	17	deltab670	deltab670	NOUN
dti-1318	174	18	in	in	ADP
dti-1318	174	19	peripheral	peripheral	ADJ
dti-1318	174	20	blood	blood	NOUN
dti-1318	174	21	mononuclear	mononuclear	ADJ
dti-1318	174	22	cells	cell	NOUN
dti-1318	174	23	during	during	ADP
dti-1318	174	24	therapy	therapy	NOUN
dti-1318	174	25	with	with	ADP
dti-1318	174	26	the	the	DET
dti-1318	174	27	zinc	zinc	NOUN
dti-1318	174	28	finger	finger	NOUN
dti-1318	174	29	inhibitor	inhibitor	NOUN
dti-1318	174	30	,	,	PUNCT
dti-1318	174	31	s	s	NOUN
dti-1318	174	32	-	-	PUNCT
dti-1318	174	33	acyl	acyl	ADJ
dti-1318	174	34	2	2	NUM
dti-1318	174	35	-	-	PUNCT
dti-1318	174	36	mercaptobenzamide	mercaptobenzamide	NOUN
dti-1318	174	37	thioester	thioester	NOUN
dti-1318	174	38	(	(	PUNCT
dti-1318	174	39	samt	samt	PROPN
dti-1318	174	40	)	)	PUNCT
dti-1318	174	41	,	,	PUNCT
dti-1318	174	42	although	although	SCONJ
dti-1318	174	43	there	there	PRON
dti-1318	174	44	was	be	VERB
dti-1318	174	45	no	no	DET
dti-1318	174	46	effect	effect	NOUN
dti-1318	174	47	on	on	ADP
dti-1318	174	48	viral	viral	ADJ
dti-1318	174	49	load	load	NOUN
dti-1318	174	50	(	(	PUNCT
dti-1318	174	51	schito	schito	VERB
dti-1318	174	52	et	et	PROPN
dti-1318	174	53	al	al	PROPN
dti-1318	174	54	.	.	PROPN
dti-1318	174	55	2006	2006	NUM
dti-1318	174	56	)	)	PUNCT
dti-1318	174	57	.	.	PUNCT
dti-1318	175	1	further	further	ADJ
dti-1318	175	2	studies	study	NOUN
dti-1318	175	3	are	be	AUX
dti-1318	175	4	in	in	ADP
dti-1318	175	5	progress	progress	NOUN
dti-1318	175	6	to	to	PART
dti-1318	175	7	optimise	optimise	VERB
dti-1318	175	8	the	the	DET
dti-1318	175	9	bioavailability	bioavailability	NOUN
dti-1318	175	10	and	and	CCONJ
dti-1318	175	11	pharmacokinetics	pharmacokinetic	NOUN
dti-1318	175	12	of	of	ADP
dti-1318	175	13	this	this	DET
dti-1318	175	14	promising	promising	ADJ
dti-1318	175	15	inhibitor	inhibitor	NOUN
dti-1318	175	16	.	.	PUNCT
dti-1318	176	1	targeting	target	VERB
dti-1318	176	2	hiv-1	hiv-1	X
dti-1318	176	3	pr	pr	NOUN
dti-1318	176	4	much	much	ADJ
dti-1318	176	5	of	of	ADP
dti-1318	176	6	our	our	PRON
dti-1318	176	7	understanding	understanding	NOUN
dti-1318	176	8	of	of	ADP
dti-1318	176	9	how	how	SCONJ
dti-1318	176	10	the	the	DET
dti-1318	176	11	pr	pr	NOUN
dti-1318	176	12	domain	domain	NOUN
dti-1318	176	13	in	in	ADP
dti-1318	176	14	gag	gag	NOUN
dti-1318	176	15	-	-	PUNCT
dti-1318	176	16	pol	pol	NOUN
dti-1318	176	17	is	be	AUX
dti-1318	176	18	activated	activate	VERB
dti-1318	176	19	and	and	CCONJ
dti-1318	176	20	the	the	DET
dti-1318	176	21	processing	processing	NOUN
dti-1318	176	22	cascade	cascade	NOUN
dti-1318	176	23	of	of	ADP
dti-1318	176	24	gag	gag	NOUN
dti-1318	176	25	and	and	CCONJ
dti-1318	176	26	gag	gag	NOUN
dti-1318	176	27	-	-	PUNCT
dti-1318	176	28	pol	pol	NOUN
dti-1318	176	29	are	be	AUX
dti-1318	176	30	due	due	ADJ
dti-1318	176	31	to	to	ADP
dti-1318	176	32	the	the	DET
dti-1318	176	33	contributions	contribution	NOUN
dti-1318	176	34	of	of	ADP
dti-1318	176	35	kaplan	kaplan	PROPN
dti-1318	176	36	and	and	CCONJ
dti-1318	176	37	colleagues	colleague	NOUN
dti-1318	176	38	(	(	PUNCT
dti-1318	176	39	kaplan	kaplan	PROPN
dti-1318	176	40	et	et	PROPN
dti-1318	176	41	al	al	PROPN
dti-1318	176	42	.	.	PROPN
dti-1318	176	43	1994	1994	NUM
dti-1318	176	44	;	;	PUNCT
dti-1318	176	45	pettit	pettit	PROPN
dti-1318	176	46	et	et	PROPN
dti-1318	176	47	al	al	PROPN
dti-1318	176	48	.	.	PROPN
dti-1318	176	49	2005	2005	NUM
dti-1318	176	50	)	)	PUNCT
dti-1318	176	51	.	.	PUNCT
dti-1318	177	1	strict	strict	ADJ
dti-1318	177	2	regulation	regulation	NOUN
dti-1318	177	3	of	of	ADP
dti-1318	177	4	pr	pr	NOUN
dti-1318	177	5	function	function	NOUN
dti-1318	177	6	is	be	AUX
dti-1318	177	7	critical	critical	ADJ
dti-1318	177	8	for	for	ADP
dti-1318	177	9	effi	effi	PROPN
dti-1318	177	10	cient	cient	NOUN
dti-1318	177	11	production	production	NOUN
dti-1318	177	12	of	of	ADP
dti-1318	177	13	mature	mature	ADJ
dti-1318	177	14	viral	viral	ADJ
dti-1318	177	15	particles	particle	NOUN
dti-1318	177	16	.	.	PUNCT
dti-1318	178	1	premature	premature	ADJ
dti-1318	178	2	activation	activation	NOUN
dti-1318	178	3	,	,	PUNCT
dti-1318	178	4	partial	partial	ADJ
dti-1318	178	5	inhibition	inhibition	NOUN
dti-1318	178	6	,	,	PUNCT
dti-1318	178	7	or	or	CCONJ
dti-1318	178	8	over	over	ADP
dti-1318	178	9	-	-	PUNCT
dti-1318	178	10	expression	expression	NOUN
dti-1318	178	11	of	of	ADP
dti-1318	178	12	hiv-1	hiv-1	X
dti-1318	178	13	pr	pr	NOUN
dti-1318	178	14	leads	lead	VERB
dti-1318	178	15	to	to	ADP
dti-1318	178	16	major	major	ADJ
dti-1318	178	17	defects	defect	NOUN
dti-1318	178	18	in	in	ADP
dti-1318	178	19	viral	viral	ADJ
dti-1318	178	20	assembly	assembly	NOUN
dti-1318	178	21	and	and	CCONJ
dti-1318	178	22	the	the	DET
dti-1318	178	23	production	production	NOUN
dti-1318	178	24	of	of	ADP
dti-1318	178	25	non	non	ADJ
dti-1318	178	26	-	-	ADJ
dti-1318	178	27	infectious	infectious	ADJ
dti-1318	178	28	viral	viral	ADJ
dti-1318	178	29	particles	particle	NOUN
dti-1318	178	30	(	(	PUNCT
dti-1318	178	31	krausslich	krausslich	PROPN
dti-1318	178	32	,	,	PUNCT
dti-1318	178	33	1991	1991	NUM
dti-1318	178	34	;	;	PUNCT
dti-1318	178	35	kaplan	kaplan	PROPN
dti-1318	178	36	et	et	PROPN
dti-1318	178	37	al	al	PROPN
dti-1318	178	38	.	.	PROPN
dti-1318	178	39	1993	1993	NUM
dti-1318	178	40	;	;	PUNCT
dti-1318	178	41	karacostas	karacosta	NOUN
dti-1318	178	42	et	et	PROPN
dti-1318	178	43	al	al	PROPN
dti-1318	178	44	.	.	PROPN
dti-1318	178	45	1993	1993	NUM
dti-1318	178	46	)	)	PUNCT
dti-1318	178	47	.	.	PUNCT
dti-1318	179	1	hence	hence	ADV
dti-1318	179	2	novel	novel	ADJ
dti-1318	179	3	inhibitors	inhibitor	NOUN
dti-1318	179	4	designed	design	VERB
dti-1318	179	5	to	to	PART
dti-1318	179	6	prevent	prevent	VERB
dti-1318	179	7	or	or	CCONJ
dti-1318	179	8	perturb	perturb	VERB
dti-1318	179	9	pr	pr	NOUN
dti-1318	179	10	dimerization	dimerization	NOUN
dti-1318	179	11	could	could	AUX
dti-1318	179	12	potentially	potentially	ADV
dti-1318	179	13	inhibit	inhibit	VERB
dti-1318	179	14	the	the	DET
dti-1318	179	15	mature	mature	ADJ
dti-1318	179	16	pr	pr	NOUN
dti-1318	179	17	homodimer	homodimer	NOUN
dti-1318	179	18	and	and	CCONJ
dti-1318	179	19	the	the	DET
dti-1318	179	20	immature	immature	ADJ
dti-1318	179	21	gag	gag	NOUN
dti-1318	179	22	-	-	PUNCT
dti-1318	179	23	pol	pol	NOUN
dti-1318	179	24	embedded	embed	VERB
dti-1318	179	25	pr	pr	NOUN
dti-1318	179	26	.	.	PUNCT
dti-1318	180	1	targeting	target	VERB
dti-1318	180	2	the	the	DET
dti-1318	180	3	pr	pr	NOUN
dti-1318	180	4	dimer	dimer	NOUN
dti-1318	180	5	interface	interface	NOUN
dti-1318	180	6	with	with	ADP
dti-1318	180	7	interface	interface	NOUN
dti-1318	180	8	peptides	peptide	NOUN
dti-1318	180	9	hiv-1	hiv-1	X
dti-1318	180	10	pr	pr	NOUN
dti-1318	180	11	is	be	AUX
dti-1318	180	12	a	a	DET
dti-1318	180	13	homodimeric	homodimeric	ADJ
dti-1318	180	14	aspartyl	aspartyl	NOUN
dti-1318	180	15	protease	protease	NOUN
dti-1318	180	16	formed	form	VERB
dti-1318	180	17	by	by	ADP
dti-1318	180	18	the	the	DET
dti-1318	180	19	symmetrical	symmetrical	ADJ
dti-1318	180	20	association	association	NOUN
dti-1318	180	21	of	of	ADP
dti-1318	180	22	two	two	NUM
dti-1318	180	23	99	99	NUM
dti-1318	180	24	amino	amino	NOUN
dti-1318	180	25	acid	acid	NOUN
dti-1318	180	26	subunits	subunit	NOUN
dti-1318	180	27	.	.	PUNCT
dti-1318	181	1	the	the	DET
dti-1318	181	2	crystal	crystal	NOUN
dti-1318	181	3	structure	structure	NOUN
dti-1318	181	4	reveals	reveal	VERB
dti-1318	181	5	a	a	DET
dti-1318	181	6	compact	compact	ADJ
dti-1318	181	7	,	,	PUNCT
dti-1318	181	8	predominantly	predominantly	ADV
dti-1318	181	9	β	β	X
dti-1318	181	10	-	-	ADJ
dti-1318	181	11	strand	strand	ADJ
dti-1318	181	12	structure	structure	NOUN
dti-1318	181	13	with	with	ADP
dti-1318	181	14	a	a	DET
dti-1318	181	15	short	short	ADJ
dti-1318	181	16	α	α	VERB
dti-1318	181	17	-	-	PUNCT
dti-1318	181	18	helix	helix	ADJ
dti-1318	181	19	region	region	NOUN
dti-1318	181	20	near	near	ADP
dti-1318	181	21	the	the	DET
dti-1318	181	22	c	c	PROPN
dti-1318	181	23	terminus	terminus	NOUN
dti-1318	181	24	(	(	PUNCT
dti-1318	181	25	wlodawer	wlodawer	NOUN
dti-1318	181	26	et	et	PROPN
dti-1318	181	27	al	al	PROPN
dti-1318	181	28	.	.	PROPN
dti-1318	181	29	1989	1989	NUM
dti-1318	181	30	)	)	PUNCT
dti-1318	181	31	.	.	PUNCT
dti-1318	182	1	dimerization	dimerization	NOUN
dti-1318	182	2	of	of	ADP
dti-1318	182	3	the	the	DET
dti-1318	182	4	pr	pr	NOUN
dti-1318	182	5	monomers	monomer	NOUN
dti-1318	182	6	generates	generate	VERB
dti-1318	182	7	both	both	CCONJ
dti-1318	182	8	the	the	DET
dti-1318	182	9	substrate	substrate	NOUN
dti-1318	182	10	-	-	PUNCT
dti-1318	182	11	binding	bind	VERB
dti-1318	182	12	pocket	pocket	NOUN
dti-1318	182	13	and	and	CCONJ
dti-1318	182	14	the	the	DET
dti-1318	182	15	catalytic	catalytic	ADJ
dti-1318	182	16	centre	centre	NOUN
dti-1318	182	17	and	and	CCONJ
dti-1318	182	18	is	be	AUX
dti-1318	182	19	essential	essential	ADJ
dti-1318	182	20	for	for	ADP
dti-1318	182	21	pr	pr	NOUN
dti-1318	182	22	activity	activity	NOUN
dti-1318	182	23	(	(	PUNCT
dti-1318	182	24	cheng	cheng	PROPN
dti-1318	182	25	et	et	PROPN
dti-1318	182	26	al	al	PROPN
dti-1318	182	27	.	.	PROPN
dti-1318	182	28	1990	1990	NUM
dti-1318	182	29	)	)	PUNCT
dti-1318	182	30	.	.	PUNCT
dti-1318	183	1	the	the	DET
dti-1318	183	2	pr	pr	NOUN
dti-1318	183	3	dimer	dimer	NOUN
dti-1318	183	4	has	have	VERB
dti-1318	183	5	a	a	DET
dti-1318	183	6	dissociation	dissociation	NOUN
dti-1318	183	7	constant	constant	ADJ
dti-1318	183	8	of	of	ADP
dti-1318	183	9	50	50	NUM
dti-1318	183	10	nm	nm	NOUN
dti-1318	183	11	and	and	CCONJ
dti-1318	183	12	gibbs	gibbs	PROPN
dti-1318	183	13	free	free	ADJ
dti-1318	183	14	energy	energy	NOUN
dti-1318	183	15	of	of	ADP
dti-1318	183	16	dimer	dimer	ADJ
dti-1318	183	17	stabilisation	stabilisation	NOUN
dti-1318	183	18	of	of	ADP
dti-1318	183	19	10	10	NUM
dti-1318	183	20	kcal	kcal	NOUN
dti-1318	183	21	/	/	SYM
dti-1318	183	22	mol	mol	PROPN
dti-1318	183	23	(	(	PUNCT
dti-1318	183	24	25	25	NUM
dti-1318	183	25	oc	oc	NOUN
dti-1318	183	26	,	,	PUNCT
dti-1318	183	27	ph	ph	X
dti-1318	183	28	3.4	3.4	NUM
dti-1318	183	29	)	)	PUNCT
dti-1318	183	30	.	.	PUNCT
dti-1318	184	1	nearly	nearly	ADV
dti-1318	184	2	75	75	NUM
dti-1318	184	3	%	%	NOUN
dti-1318	184	4	of	of	ADP
dti-1318	184	5	the	the	DET
dti-1318	184	6	binding	bind	VERB
dti-1318	184	7	energy	energy	NOUN
dti-1318	184	8	is	be	AUX
dti-1318	184	9	contributed	contribute	VERB
dti-1318	184	10	by	by	ADP
dti-1318	184	11	the	the	DET
dti-1318	184	12	four	four	NUM
dti-1318	184	13	-	-	PUNCT
dti-1318	184	14	stranded	strand	VERB
dti-1318	184	15	β	β	NOUN
dti-1318	184	16	-	-	NOUN
dti-1318	184	17	sheet	sheet	NOUN
dti-1318	184	18	formed	form	VERB
dti-1318	184	19	by	by	ADP
dti-1318	184	20	the	the	DET
dti-1318	184	21	nand	nand	NOUN
dti-1318	184	22	c	c	NOUN
dti-1318	184	23	-	-	PUNCT
dti-1318	184	24	termini	termini	NOUN
dti-1318	184	25	(	(	PUNCT
dti-1318	184	26	todd	todd	PROPN
dti-1318	184	27	et	et	PROPN
dti-1318	184	28	al	al	PROPN
dti-1318	184	29	.	.	PROPN
dti-1318	185	1	1998).the	1998).the	NUM
dti-1318	185	2	four	four	NUM
dti-1318	185	3	-	-	PUNCT
dti-1318	185	4	stranded	strand	VERB
dti-1318	185	5	β	β	NOUN
dti-1318	185	6	-	-	NOUN
dti-1318	185	7	sheet	sheet	NOUN
dti-1318	185	8	comprising	comprise	VERB
dti-1318	185	9	the	the	DET
dti-1318	185	10	nand	nand	NOUN
dti-1318	185	11	c	c	NOUN
dti-1318	185	12	-	-	PUNCT
dti-1318	185	13	termini	termini	NOUN
dti-1318	185	14	from	from	ADP
dti-1318	185	15	each	each	DET
dti-1318	185	16	pr	pr	NOUN
dti-1318	185	17	monomer	monomer	NOUN
dti-1318	185	18	represents	represent	VERB
dti-1318	185	19	an	an	DET
dti-1318	185	20	attractive	attractive	ADJ
dti-1318	185	21	drug	drug	NOUN
dti-1318	185	22	target	target	NOUN
dti-1318	185	23	for	for	ADP
dti-1318	185	24	the	the	DET
dti-1318	185	25	following	follow	VERB
dti-1318	185	26	reasons	reason	NOUN
dti-1318	185	27	:	:	PUNCT
dti-1318	186	1	1	1	X
dti-1318	186	2	.	.	X
dti-1318	186	3	it	it	PRON
dti-1318	186	4	is	be	AUX
dti-1318	186	5	the	the	DET
dti-1318	186	6	major	major	ADJ
dti-1318	186	7	stabilising	stabilise	VERB
dti-1318	186	8	region	region	NOUN
dti-1318	186	9	of	of	ADP
dti-1318	186	10	the	the	DET
dti-1318	186	11	active	active	ADJ
dti-1318	186	12	dimer	dimer	NOUN
dti-1318	186	13	,	,	PUNCT
dti-1318	186	14	2	2	X
dti-1318	186	15	.	.	PUNCT
dti-1318	187	1	the	the	DET
dti-1318	187	2	region	region	NOUN
dti-1318	187	3	is	be	AUX
dti-1318	187	4	relatively	relatively	ADV
dti-1318	187	5	free	free	ADJ
dti-1318	187	6	of	of	ADP
dti-1318	187	7	known	known	ADJ
dti-1318	187	8	pr	pr	NOUN
dti-1318	187	9	resistance	resistance	NOUN
dti-1318	187	10	mutations	mutation	NOUN
dti-1318	187	11	,	,	PUNCT
dti-1318	187	12	3	3	X
dti-1318	187	13	.	.	PUNCT
dti-1318	188	1	the	the	DET
dti-1318	188	2	sequence	sequence	NOUN
dti-1318	188	3	is	be	AUX
dti-1318	188	4	highly	highly	ADV
dti-1318	188	5	conserved	conserved	ADJ
dti-1318	188	6	in	in	ADP
dti-1318	188	7	most	most	ADJ
dti-1318	188	8	hiv-1	hiv-1	NUM
dti-1318	188	9	and	and	CCONJ
dti-1318	188	10	hiv-2	hiv-2	NUM
dti-1318	188	11	isolates	isolate	NOUN
dti-1318	188	12	and	and	CCONJ
dti-1318	188	13	4	4	NUM
dti-1318	188	14	.	.	X
dti-1318	189	1	it	it	PRON
dti-1318	189	2	provides	provide	VERB
dti-1318	189	3	a	a	DET
dti-1318	189	4	unique	unique	ADJ
dti-1318	189	5	target	target	NOUN
dti-1318	189	6	minimising	minimise	VERB
dti-1318	189	7	potential	potential	ADJ
dti-1318	189	8	toxicity	toxicity	NOUN
dti-1318	189	9	issues	issue	NOUN
dti-1318	189	10	for	for	ADP
dti-1318	189	11	eukaryotic	eukaryotic	ADJ
dti-1318	189	12	aspartyl	aspartyl	NOUN
dti-1318	189	13	proteases	protease	NOUN
dti-1318	189	14	(	(	PUNCT
dti-1318	189	15	gustchina	gustchina	NOUN
dti-1318	189	16	and	and	CCONJ
dti-1318	189	17	weber	weber	PROPN
dti-1318	189	18	,	,	PUNCT
dti-1318	189	19	1991	1991	NUM
dti-1318	189	20	)	)	PUNCT
dti-1318	189	21	.	.	PUNCT
dti-1318	190	1	a	a	DET
dti-1318	190	2	standard	standard	ADJ
dti-1318	190	3	methodology	methodology	NOUN
dti-1318	190	4	for	for	ADP
dti-1318	190	5	analysing	analyse	VERB
dti-1318	190	6	potential	potential	ADJ
dti-1318	190	7	pr	pr	NOUN
dti-1318	190	8	inhibitors	inhibitor	NOUN
dti-1318	190	9	that	that	PRON
dti-1318	190	10	prevent	prevent	VERB
dti-1318	190	11	pr	pr	NOUN
dti-1318	190	12	dimerization	dimerization	NOUN
dti-1318	190	13	(	(	PUNCT
dti-1318	190	14	dissociative	dissociative	ADJ
dti-1318	190	15	inhibition	inhibition	NOUN
dti-1318	190	16	)	)	PUNCT
dti-1318	190	17	or	or	CCONJ
dti-1318	190	18	target	target	VERB
dti-1318	190	19	and	and	CCONJ
dti-1318	190	20	bind	bind	VERB
dti-1318	190	21	to	to	ADP
dti-1318	190	22	the	the	DET
dti-1318	190	23	pr	pr	NOUN
dti-1318	190	24	active	active	ADJ
dti-1318	190	25	site	site	NOUN
dti-1318	190	26	(	(	PUNCT
dti-1318	190	27	competitive	competitive	ADJ
dti-1318	190	28	inhibition	inhibition	NOUN
dti-1318	190	29	)	)	PUNCT
dti-1318	190	30	has	have	AUX
dti-1318	190	31	been	be	AUX
dti-1318	190	32	described	describe	VERB
dti-1318	190	33	(	(	PUNCT
dti-1318	190	34	zhang	zhang	PROPN
dti-1318	190	35	et	et	PROPN
dti-1318	190	36	al	al	PROPN
dti-1318	190	37	.	.	PROPN
dti-1318	190	38	1991	1991	NUM
dti-1318	190	39	)	)	PUNCT
dti-1318	190	40	.	.	PUNCT
dti-1318	191	1	an	an	DET
dti-1318	191	2	example	example	NOUN
dti-1318	191	3	of	of	ADP
dti-1318	191	4	a	a	DET
dti-1318	191	5	dissociative	dissociative	ADJ
dti-1318	191	6	inhibitor	inhibitor	NOUN
dti-1318	191	7	is	be	AUX
dti-1318	191	8	the	the	DET
dti-1318	191	9	c	c	NOUN
dti-1318	191	10	-	-	PUNCT
dti-1318	191	11	terminal	terminal	ADJ
dti-1318	191	12	tetrapeptide	tetrapeptide	NOUN
dti-1318	191	13	,	,	PUNCT
dti-1318	191	14	ac	ac	PROPN
dti-1318	191	15	-	-	PUNCT
dti-1318	191	16	t	t	PROPN
dti-1318	191	17	-	-	PUNCT
dti-1318	191	18	l	l	NOUN
dti-1318	191	19	-	-	PUNCT
dti-1318	191	20	n	n	CCONJ
dti-1318	191	21	-	-	PUNCT
dti-1318	191	22	f	f	NOUN
dti-1318	191	23	,	,	PUNCT
dti-1318	191	24	which	which	PRON
dti-1318	191	25	exhibits	exhibit	VERB
dti-1318	191	26	activity	activity	NOUN
dti-1318	191	27	in	in	ADP
dti-1318	191	28	the	the	DET
dti-1318	191	29	micromolar	micromolar	ADJ
dti-1318	191	30	range	range	NOUN
dti-1318	191	31	(	(	PUNCT
dti-1318	191	32	ki	ki	PROPN
dti-1318	191	33	45	45	NUM
dti-1318	191	34	µm	µm	NOUN
dti-1318	191	35	)	)	PUNCT
dti-1318	191	36	(	(	PUNCT
dti-1318	191	37	zhang	zhang	PROPN
dti-1318	191	38	et	et	PROPN
dti-1318	191	39	al	al	PROPN
dti-1318	191	40	.	.	PROPN
dti-1318	191	41	1991	1991	NUM
dti-1318	191	42	)	)	PUNCT
dti-1318	191	43	.	.	PUNCT
dti-1318	192	1	other	other	ADJ
dti-1318	192	2	studies	study	NOUN
dti-1318	192	3	have	have	AUX
dti-1318	192	4	also	also	ADV
dti-1318	192	5	shown	show	VERB
dti-1318	192	6	the	the	DET
dti-1318	192	7	capacity	capacity	NOUN
dti-1318	192	8	of	of	ADP
dti-1318	192	9	nand	nand	NOUN
dti-1318	192	10	c	c	NOUN
dti-1318	192	11	-	-	PUNCT
dti-1318	192	12	terminal	terminal	ADJ
dti-1318	192	13	peptides	peptide	NOUN
dti-1318	192	14	,	,	PUNCT
dti-1318	192	15	or	or	CCONJ
dti-1318	192	16	‘	'	PUNCT
dti-1318	192	17	interface	interface	NOUN
dti-1318	192	18	’	'	PUNCT
dti-1318	192	19	peptides	peptide	NOUN
dti-1318	192	20	,	,	PUNCT
dti-1318	192	21	to	to	PART
dti-1318	192	22	bind	bind	VERB
dti-1318	192	23	to	to	ADP
dti-1318	192	24	pr	pr	NOUN
dti-1318	192	25	monomers	monomer	NOUN
dti-1318	192	26	and	and	CCONJ
dti-1318	192	27	thus	thus	ADV
dti-1318	192	28	prevent	prevent	VERB
dti-1318	192	29	pr	pr	NOUN
dti-1318	192	30	dimerization	dimerization	NOUN
dti-1318	192	31	and	and	CCONJ
dti-1318	192	32	activity	activity	NOUN
dti-1318	192	33	(	(	PUNCT
dti-1318	192	34	babe	babe	NOUN
dti-1318	192	35	et	et	PROPN
dti-1318	192	36	al	al	PROPN
dti-1318	192	37	.	.	PROPN
dti-1318	192	38	1991	1991	NUM
dti-1318	192	39	;	;	PUNCT
dti-1318	192	40	franciskovich	franciskovich	NOUN
dti-1318	192	41	et	et	PROPN
dti-1318	192	42	al	al	PROPN
dti-1318	192	43	.	.	PROPN
dti-1318	192	44	1993	1993	NUM
dti-1318	192	45	;	;	PUNCT
dti-1318	192	46	schramm	schramm	PROPN
dti-1318	192	47	et	et	PROPN
dti-1318	192	48	al	al	PROPN
dti-1318	192	49	.	.	PROPN
dti-1318	192	50	1991	1991	NUM
dti-1318	192	51	;	;	PUNCT
dti-1318	192	52	schramm	schramm	PROPN
dti-1318	192	53	et	et	PROPN
dti-1318	192	54	al	al	PROPN
dti-1318	192	55	.	.	PROPN
dti-1318	192	56	1996	1996	NUM
dti-1318	192	57	)	)	PUNCT
dti-1318	192	58	.	.	PUNCT
dti-1318	193	1	the	the	DET
dti-1318	193	2	identifi	identifi	PROPN
dti-1318	193	3	cation	cation	NOUN
dti-1318	193	4	of	of	ADP
dti-1318	193	5	these	these	DET
dti-1318	193	6	lead	lead	ADJ
dti-1318	193	7	peptides	peptide	NOUN
dti-1318	193	8	provides	provide	VERB
dti-1318	193	9	proof	proof	NOUN
dti-1318	193	10	of	of	ADP
dti-1318	193	11	concept	concept	NOUN
dti-1318	193	12	that	that	SCONJ
dti-1318	193	13	targeting	target	VERB
dti-1318	193	14	the	the	DET
dti-1318	193	15	pr	pr	NOUN
dti-1318	193	16	β	β	ADJ
dti-1318	193	17	-	-	ADJ
dti-1318	193	18	sheet	sheet	NOUN
dti-1318	193	19	region	region	NOUN
dti-1318	193	20	constitutes	constitute	VERB
dti-1318	193	21	a	a	DET
dti-1318	193	22	viable	viable	ADJ
dti-1318	193	23	strategy	strategy	NOUN
dti-1318	193	24	for	for	ADP
dti-1318	193	25	the	the	DET
dti-1318	193	26	development	development	NOUN
dti-1318	193	27	of	of	ADP
dti-1318	193	28	novel	novel	ADJ
dti-1318	193	29	inhibitors	inhibitor	NOUN
dti-1318	193	30	of	of	ADP
dti-1318	193	31	hiv-1	hiv-1	X
dti-1318	193	32	pr	pr	NOUN
dti-1318	193	33	.	.	PUNCT
dti-1318	194	1	the	the	DET
dti-1318	194	2	potency	potency	NOUN
dti-1318	194	3	of	of	ADP
dti-1318	194	4	c	c	NOUN
dti-1318	194	5	-	-	PUNCT
dti-1318	194	6	terminal	terminal	ADJ
dti-1318	194	7	tetrapeptides	tetrapeptide	NOUN
dti-1318	194	8	are	be	AUX
dti-1318	194	9	increased	increase	VERB
dti-1318	194	10	by	by	ADP
dti-1318	194	11	truncation	truncation	NOUN
dti-1318	194	12	to	to	ADP
dti-1318	194	13	a	a	DET
dti-1318	194	14	core	core	NOUN
dti-1318	194	15	tripeptide	tripeptide	NOUN
dti-1318	194	16	,	,	PUNCT
dti-1318	194	17	amino	amino	NOUN
dti-1318	194	18	acid	acid	NOUN
dti-1318	194	19	modifi	modifi	PROPN
dti-1318	194	20	cation	cation	NOUN
dti-1318	194	21	,	,	PUNCT
dti-1318	194	22	and	and	CCONJ
dti-1318	194	23	the	the	DET
dti-1318	194	24	addition	addition	NOUN
dti-1318	194	25	of	of	ADP
dti-1318	194	26	a	a	DET
dti-1318	194	27	linear	linear	ADJ
dti-1318	194	28	hydrophobic	hydrophobic	NOUN
dti-1318	194	29	moiety	moiety	NOUN
dti-1318	194	30	such	such	ADJ
dti-1318	194	31	as	as	ADP
dti-1318	194	32	palmitoyl	palmitoyl	NOUN
dti-1318	194	33	to	to	ADP
dti-1318	194	34	the	the	DET
dti-1318	194	35	amino	amino	NOUN
dti-1318	194	36	168	168	NUM
dti-1318	194	37	wapling	waple	VERB
dti-1318	194	38	et	et	PROPN
dti-1318	194	39	al	al	PROPN
dti-1318	194	40	drug	drug	PROPN
dti-1318	194	41	target	target	NOUN
dti-1318	194	42	insights	insight	NOUN
dti-1318	194	43	2007	2007	NUM
dti-1318	194	44	:	:	PUNCT
dti-1318	194	45	2	2	NUM
dti-1318	194	46	hiv-1	hiv-1	X
dti-1318	194	47	pr	pr	NOUN
dti-1318	194	48	monmer	monmer	NOUN
dti-1318	194	49	n	n	CCONJ
dti-1318	194	50	-	-	PUNCT
dti-1318	194	51	terminal	terminal	ADJ
dti-1318	194	52	c	c	NOUN
dti-1318	194	53	-	-	PUNCT
dti-1318	194	54	terminal	terminal	ADJ
dti-1318	194	55	peptide	peptide	NOUN
dti-1318	194	56	peptide	peptide	NOUN
dti-1318	194	57	scaffold	scaffold	NOUN
dti-1318	194	58	‘	'	PUNCT
dti-1318	194	59	molecular	molecular	ADJ
dti-1318	194	60	tong	tong	ADJ
dti-1318	194	61	’	'	PUNCT
dti-1318	194	62	terminus	terminus	NOUN
dti-1318	194	63	of	of	ADP
dti-1318	194	64	the	the	DET
dti-1318	194	65	peptide	peptide	NOUN
dti-1318	194	66	.	.	PUNCT
dti-1318	195	1	the	the	DET
dti-1318	195	2	lipid	lipid	NOUN
dti-1318	195	3	moiety	moiety	NOUN
dti-1318	195	4	is	be	AUX
dti-1318	195	5	thought	think	VERB
dti-1318	195	6	to	to	PART
dti-1318	195	7	increase	increase	VERB
dti-1318	195	8	the	the	DET
dti-1318	195	9	dissociative	dissociative	ADJ
dti-1318	195	10	activity	activity	NOUN
dti-1318	195	11	of	of	ADP
dti-1318	195	12	the	the	DET
dti-1318	195	13	peptides	peptide	NOUN
dti-1318	195	14	by	by	ADP
dti-1318	195	15	directing	direct	VERB
dti-1318	195	16	it	it	PRON
dti-1318	195	17	to	to	ADP
dti-1318	195	18	the	the	DET
dti-1318	195	19	hydrophobic	hydrophobic	NOUN
dti-1318	195	20	pr	pr	NOUN
dti-1318	195	21	interface	interface	NOUN
dti-1318	195	22	(	(	PUNCT
dti-1318	195	23	schramm	schramm	PROPN
dti-1318	195	24	et	et	PROPN
dti-1318	195	25	al	al	PROPN
dti-1318	195	26	.	.	PROPN
dti-1318	195	27	1999	1999	NUM
dti-1318	195	28	)	)	PUNCT
dti-1318	195	29	.	.	PUNCT
dti-1318	196	1	however	however	ADV
dti-1318	196	2	,	,	PUNCT
dti-1318	196	3	despite	despite	SCONJ
dti-1318	196	4	their	their	PRON
dti-1318	196	5	capacity	capacity	NOUN
dti-1318	196	6	to	to	PART
dti-1318	196	7	inhibit	inhibit	VERB
dti-1318	196	8	pr	pr	NOUN
dti-1318	196	9	activity	activity	NOUN
dti-1318	196	10	at	at	ADP
dti-1318	196	11	low	low	ADJ
dti-1318	196	12	nanomolar	nanomolar	ADJ
dti-1318	196	13	concentrations	concentration	NOUN
dti-1318	196	14	,	,	PUNCT
dti-1318	196	15	these	these	DET
dti-1318	196	16	lipopeptides	lipopeptide	NOUN
dti-1318	196	17	are	be	AUX
dti-1318	196	18	poorly	poorly	ADV
dti-1318	196	19	soluble	soluble	ADJ
dti-1318	196	20	and	and	CCONJ
dti-1318	196	21	susceptible	susceptible	ADJ
dti-1318	196	22	to	to	ADP
dti-1318	196	23	protein	protein	NOUN
dti-1318	196	24	degradation	degradation	NOUN
dti-1318	196	25	.	.	PUNCT
dti-1318	197	1	further	further	PROPN
dti-1318	197	2	modifi	modifi	PROPN
dti-1318	197	3	cations	cation	NOUN
dti-1318	197	4	have	have	AUX
dti-1318	197	5	been	be	AUX
dti-1318	197	6	made	make	VERB
dti-1318	197	7	to	to	ADP
dti-1318	197	8	the	the	DET
dti-1318	197	9	lipopeptides	lipopeptide	NOUN
dti-1318	197	10	by	by	ADP
dti-1318	197	11	making	make	VERB
dti-1318	197	12	them	they	PRON
dti-1318	197	13	less	less	ADV
dti-1318	197	14	peptide	peptide	NOUN
dti-1318	197	15	-	-	PUNCT
dti-1318	197	16	like	like	ADJ
dti-1318	197	17	(	(	PUNCT
dti-1318	197	18	cafl	cafl	NOUN
dti-1318	197	19	isch	isch	X
dti-1318	197	20	et	et	PROPN
dti-1318	197	21	al	al	PROPN
dti-1318	197	22	.	.	PROPN
dti-1318	197	23	2000	2000	NUM
dti-1318	197	24	)	)	PUNCT
dti-1318	197	25	and	and	CCONJ
dti-1318	197	26	by	by	ADP
dti-1318	197	27	modifying	modify	VERB
dti-1318	197	28	the	the	DET
dti-1318	197	29	lipid	lipid	ADJ
dti-1318	197	30	moiety	moiety	NOUN
dti-1318	197	31	to	to	PART
dti-1318	197	32	increase	increase	VERB
dti-1318	197	33	their	their	PRON
dti-1318	197	34	solubility	solubility	NOUN
dti-1318	197	35	while	while	SCONJ
dti-1318	197	36	retaining	retain	VERB
dti-1318	197	37	potency	potency	NOUN
dti-1318	197	38	(	(	PUNCT
dti-1318	197	39	dumond	dumond	NOUN
dti-1318	197	40	et	et	PROPN
dti-1318	197	41	al	al	PROPN
dti-1318	197	42	.	.	PROPN
dti-1318	197	43	2003	2003	NUM
dti-1318	197	44	)	)	PUNCT
dti-1318	197	45	.	.	PUNCT
dti-1318	198	1	cross	cross	ADJ
dti-1318	198	2	-	-	ADJ
dti-1318	198	3	linking	link	VERB
dti-1318	198	4	interfacial	interfacial	ADJ
dti-1318	198	5	peptides	peptide	NOUN
dti-1318	198	6	represent	represent	VERB
dti-1318	198	7	another	another	DET
dti-1318	198	8	strategy	strategy	NOUN
dti-1318	198	9	,	,	PUNCT
dti-1318	198	10	with	with	ADP
dti-1318	198	11	the	the	DET
dti-1318	198	12	aim	aim	NOUN
dti-1318	198	13	to	to	PART
dti-1318	198	14	increase	increase	VERB
dti-1318	198	15	the	the	DET
dti-1318	198	16	affi	affi	ADJ
dti-1318	198	17	nity	nity	NOUN
dti-1318	198	18	of	of	ADP
dti-1318	198	19	the	the	DET
dti-1318	198	20	peptides	peptide	NOUN
dti-1318	198	21	by	by	ADP
dti-1318	198	22	presenting	present	VERB
dti-1318	198	23	them	they	PRON
dti-1318	198	24	in	in	ADP
dti-1318	198	25	a	a	DET
dti-1318	198	26	conformation	conformation	NOUN
dti-1318	198	27	similar	similar	ADJ
dti-1318	198	28	to	to	ADP
dti-1318	198	29	a	a	DET
dti-1318	198	30	pr	pr	NOUN
dti-1318	198	31	monomer	monomer	NOUN
dti-1318	198	32	.	.	PUNCT
dti-1318	199	1	the	the	DET
dti-1318	199	2	fi	fi	NOUN
dti-1318	199	3	rst	rst	PROPN
dti-1318	199	4	interface	interface	NOUN
dti-1318	199	5	tetrapeptides	tetrapeptide	NOUN
dti-1318	199	6	tethered	tether	VERB
dti-1318	199	7	with	with	ADP
dti-1318	199	8	a	a	DET
dti-1318	199	9	glycine	glycine	NOUN
dti-1318	199	10	linker	linker	NOUN
dti-1318	199	11	display	display	VERB
dti-1318	199	12	greater	great	ADJ
dti-1318	199	13	potency	potency	NOUN
dti-1318	199	14	(	(	PUNCT
dti-1318	199	15	pf1	pf1	NOUN
dti-1318	199	16	,	,	PUNCT
dti-1318	199	17	ic50=	ic50=	PROPN
dti-1318	199	18	40	40	NUM
dti-1318	199	19	µm	µm	NOUN
dti-1318	199	20	)	)	PUNCT
dti-1318	199	21	compared	compare	VERB
dti-1318	199	22	to	to	ADP
dti-1318	199	23	free	free	ADJ
dti-1318	199	24	tetrapeptides	tetrapeptide	NOUN
dti-1318	199	25	(	(	PUNCT
dti-1318	199	26	ic50	ic50	PROPN
dti-1318	199	27	≥	≥	NUM
dti-1318	199	28	150	150	NUM
dti-1318	199	29	µm	µm	NOUN
dti-1318	199	30	)	)	PUNCT
dti-1318	199	31	(	(	PUNCT
dti-1318	199	32	babe	babe	NOUN
dti-1318	199	33	et	et	PROPN
dti-1318	199	34	al	al	PROPN
dti-1318	199	35	.	.	PROPN
dti-1318	199	36	1992	1992	NUM
dti-1318	199	37	)	)	PUNCT
dti-1318	199	38	.	.	PUNCT
dti-1318	200	1	this	this	DET
dti-1318	200	2	approach	approach	NOUN
dti-1318	200	3	has	have	AUX
dti-1318	200	4	evolved	evolve	VERB
dti-1318	200	5	to	to	ADP
dti-1318	200	6	linking	link	VERB
dti-1318	200	7	peptides	peptide	NOUN
dti-1318	200	8	with	with	ADP
dti-1318	200	9	fl	fl	ADP
dti-1318	200	10	exible	exible	ADJ
dti-1318	200	11	alkyl	alkyl	NOUN
dti-1318	200	12	tethers	tether	NOUN
dti-1318	200	13	(	(	PUNCT
dti-1318	200	14	zutshi	zutshi	ADJ
dti-1318	200	15	and	and	CCONJ
dti-1318	200	16	chmielewski	chmielewski	ADJ
dti-1318	200	17	,	,	PUNCT
dti-1318	200	18	2000	2000	NUM
dti-1318	200	19	)	)	PUNCT
dti-1318	200	20	and	and	CCONJ
dti-1318	200	21	semirigid	semirigid	ADJ
dti-1318	200	22	alkyl	alkyl	NOUN
dti-1318	200	23	based	base	VERB
dti-1318	200	24	tethers	tether	NOUN
dti-1318	200	25	(	(	PUNCT
dti-1318	200	26	ulysse	ulysse	NOUN
dti-1318	200	27	and	and	CCONJ
dti-1318	200	28	chmielewski	chmielewski	ADJ
dti-1318	200	29	,	,	PUNCT
dti-1318	200	30	1998	1998	NUM
dti-1318	200	31	)	)	PUNCT
dti-1318	200	32	,	,	PUNCT
dti-1318	200	33	which	which	PRON
dti-1318	200	34	increase	increase	VERB
dti-1318	200	35	the	the	DET
dti-1318	200	36	distance	distance	NOUN
dti-1318	200	37	between	between	ADP
dti-1318	200	38	the	the	DET
dti-1318	200	39	peptides	peptide	NOUN
dti-1318	200	40	to	to	PART
dti-1318	200	41	approximate	approximate	VERB
dti-1318	200	42	that	that	PRON
dti-1318	200	43	of	of	ADP
dti-1318	200	44	the	the	DET
dti-1318	200	45	pr	pr	NOUN
dti-1318	200	46	termini	termini	NOUN
dti-1318	200	47	in	in	ADP
dti-1318	200	48	the	the	DET
dti-1318	200	49	dimer	dimer	NOUN
dti-1318	200	50	(	(	PUNCT
dti-1318	200	51	~10	~10	NOUN
dti-1318	200	52	å	å	X
dti-1318	200	53	)	)	PUNCT
dti-1318	200	54	.	.	PUNCT
dti-1318	201	1	the	the	DET
dti-1318	201	2	conformational	conformational	ADJ
dti-1318	201	3	freedom	freedom	NOUN
dti-1318	201	4	of	of	ADP
dti-1318	201	5	these	these	DET
dti-1318	201	6	linked	link	VERB
dti-1318	201	7	peptides	peptide	NOUN
dti-1318	201	8	was	be	AUX
dti-1318	201	9	addressed	address	VERB
dti-1318	201	10	by	by	ADP
dti-1318	201	11	the	the	DET
dti-1318	201	12	use	use	NOUN
dti-1318	201	13	of	of	ADP
dti-1318	201	14	pyridinediol	pyridinediol	NOUN
dti-1318	201	15	and	and	CCONJ
dti-1318	201	16	naphthalene	naphthalene	NOUN
dti-1318	201	17	based	base	VERB
dti-1318	201	18	molecularly	molecularly	ADV
dti-1318	201	19	constrained	constrain	VERB
dti-1318	201	20	scaffolds	scaffold	NOUN
dti-1318	201	21	(	(	PUNCT
dti-1318	201	22	bouras	boura	NOUN
dti-1318	201	23	et	et	PROPN
dti-1318	201	24	al	al	PROPN
dti-1318	201	25	.	.	PROPN
dti-1318	201	26	1999	1999	NUM
dti-1318	201	27	;	;	PUNCT
dti-1318	201	28	song	song	NOUN
dti-1318	201	29	et	et	PROPN
dti-1318	201	30	al	al	PROPN
dti-1318	201	31	.	.	PROPN
dti-1318	201	32	2001	2001	NUM
dti-1318	201	33	;	;	PUNCT
dti-1318	201	34	merabet	merabet	PROPN
dti-1318	201	35	et	et	PROPN
dti-1318	201	36	al	al	PROPN
dti-1318	201	37	.	.	PROPN
dti-1318	201	38	2004	2004	NUM
dti-1318	201	39	;	;	PUNCT
dti-1318	201	40	bannwarth	bannwarth	NOUN
dti-1318	201	41	et	et	PROPN
dti-1318	201	42	al	al	PROPN
dti-1318	201	43	.	.	PROPN
dti-1318	201	44	2006	2006	NUM
dti-1318	201	45	)	)	PUNCT
dti-1318	201	46	.	.	PUNCT
dti-1318	202	1	known	know	VERB
dti-1318	202	2	as	as	ADP
dti-1318	202	3	‘	'	PUNCT
dti-1318	202	4	molecular	molecular	ADJ
dti-1318	202	5	tongs	tong	NOUN
dti-1318	202	6	’	'	PUNCT
dti-1318	202	7	,	,	PUNCT
dti-1318	202	8	these	these	DET
dti-1318	202	9	compounds	compound	NOUN
dti-1318	202	10	are	be	AUX
dti-1318	202	11	designed	design	VERB
dti-1318	202	12	to	to	PART
dti-1318	202	13	position	position	VERB
dti-1318	202	14	the	the	DET
dti-1318	202	15	interface	interface	NOUN
dti-1318	202	16	peptides	peptide	NOUN
dti-1318	202	17	to	to	PART
dti-1318	202	18	clamp	clamp	VERB
dti-1318	202	19	the	the	DET
dti-1318	202	20	termini	termini	NOUN
dti-1318	202	21	of	of	ADP
dti-1318	202	22	a	a	DET
dti-1318	202	23	pr	pr	NOUN
dti-1318	202	24	monomer	monomer	NOUN
dti-1318	202	25	(	(	PUNCT
dti-1318	202	26	fig	fig	NOUN
dti-1318	202	27	.	.	PUNCT
dti-1318	203	1	2	2	NUM
dti-1318	203	2	)	)	PUNCT
dti-1318	203	3	.	.	PUNCT
dti-1318	204	1	these	these	DET
dti-1318	204	2	studies	study	NOUN
dti-1318	204	3	have	have	AUX
dti-1318	204	4	culminated	culminate	VERB
dti-1318	204	5	in	in	ADP
dti-1318	204	6	a	a	DET
dti-1318	204	7	set	set	NOUN
dti-1318	204	8	of	of	ADP
dti-1318	204	9	optimised	optimise	VERB
dti-1318	204	10	tongs	tong	NOUN
dti-1318	204	11	with	with	ADP
dti-1318	204	12	symmetrical	symmetrical	ADJ
dti-1318	204	13	peptidomimetic	peptidomimetic	ADJ
dti-1318	204	14	sequences	sequence	NOUN
dti-1318	204	15	based	base	VERB
dti-1318	204	16	on	on	ADP
dti-1318	204	17	an	an	DET
dti-1318	204	18	optimised	optimise	VERB
dti-1318	204	19	pr	pr	NOUN
dti-1318	204	20	c	c	NOUN
dti-1318	204	21	-	-	PUNCT
dti-1318	204	22	terminal	terminal	ADJ
dti-1318	204	23	sequence	sequence	NOUN
dti-1318	204	24	.	.	PUNCT
dti-1318	205	1	the	the	DET
dti-1318	205	2	tongs	tong	NOUN
dti-1318	205	3	inhibit	inhibit	VERB
dti-1318	205	4	the	the	DET
dti-1318	205	5	activity	activity	NOUN
dti-1318	205	6	of	of	ADP
dti-1318	205	7	hiv-1	hiv-1	X
dti-1318	205	8	pr	pr	NOUN
dti-1318	205	9	that	that	PRON
dti-1318	205	10	are	be	AUX
dti-1318	205	11	either	either	CCONJ
dti-1318	205	12	sensitive	sensitive	ADJ
dti-1318	205	13	or	or	CCONJ
dti-1318	205	14	resistant	resistant	ADJ
dti-1318	205	15	to	to	PART
dti-1318	205	16	pis	pis	VERB
dti-1318	205	17	with	with	ADP
dti-1318	205	18	ki	ki	PROPN
dti-1318	205	19	values	value	NOUN
dti-1318	205	20	from	from	ADP
dti-1318	205	21	0.4–4.8	0.4–4.8	NOUN
dti-1318	205	22	µm	µm	NOUN
dti-1318	205	23	in	in	ADP
dti-1318	205	24	cell	cell	NOUN
dti-1318	205	25	free	free	ADJ
dti-1318	205	26	assays	assay	NOUN
dti-1318	205	27	(	(	PUNCT
dti-1318	205	28	bannwarth	bannwarth	NOUN
dti-1318	205	29	et	et	PROPN
dti-1318	205	30	al	al	PROPN
dti-1318	205	31	.	.	PROPN
dti-1318	205	32	2006	2006	NUM
dti-1318	205	33	)	)	PUNCT
dti-1318	205	34	.	.	PUNCT
dti-1318	206	1	other	other	ADJ
dti-1318	206	2	variations	variation	NOUN
dti-1318	206	3	on	on	ADP
dti-1318	206	4	the	the	DET
dti-1318	206	5	theme	theme	NOUN
dti-1318	206	6	of	of	ADP
dti-1318	206	7	interface	interface	NOUN
dti-1318	206	8	peptides	peptide	NOUN
dti-1318	206	9	include	include	VERB
dti-1318	206	10	combining	combine	VERB
dti-1318	206	11	the	the	DET
dti-1318	206	12	advantages	advantage	NOUN
dti-1318	206	13	of	of	ADP
dti-1318	206	14	lipopeptides	lipopeptide	NOUN
dti-1318	206	15	and	and	CCONJ
dti-1318	206	16	molecular	molecular	ADJ
dti-1318	206	17	tongs	tong	NOUN
dti-1318	206	18	.	.	PUNCT
dti-1318	207	1	interface	interface	NOUN
dti-1318	207	2	peptides	peptide	NOUN
dti-1318	207	3	have	have	AUX
dti-1318	207	4	been	be	AUX
dti-1318	207	5	linked	link	VERB
dti-1318	207	6	to	to	ADP
dti-1318	207	7	lipophilic	lipophilic	ADJ
dti-1318	207	8	groups	group	NOUN
dti-1318	207	9	by	by	ADP
dti-1318	207	10	a	a	DET
dti-1318	207	11	rigid	rigid	ADJ
dti-1318	207	12	bicyclic	bicyclic	NOUN
dti-1318	207	13	guanidinium	guanidinium	NOUN
dti-1318	207	14	scaffold	scaffold	NOUN
dti-1318	207	15	(	(	PUNCT
dti-1318	207	16	breccia	breccia	PROPN
dti-1318	207	17	et	et	PROPN
dti-1318	207	18	al	al	PROPN
dti-1318	207	19	.	.	PROPN
dti-1318	207	20	2003	2003	NUM
dti-1318	207	21	)	)	PUNCT
dti-1318	207	22	.	.	PUNCT
dti-1318	208	1	the	the	DET
dti-1318	208	2	most	most	ADV
dti-1318	208	3	potent	potent	ADJ
dti-1318	208	4	compound	compound	NOUN
dti-1318	208	5	demonstrates	demonstrate	VERB
dti-1318	208	6	pr	pr	VERB
dti-1318	208	7	inhibitory	inhibitory	ADJ
dti-1318	208	8	activity	activity	NOUN
dti-1318	208	9	similar	similar	ADJ
dti-1318	208	10	to	to	ADP
dti-1318	208	11	tethered	tethered	ADJ
dti-1318	208	12	peptides	peptide	NOUN
dti-1318	208	13	and	and	CCONJ
dti-1318	208	14	molecular	molecular	ADJ
dti-1318	208	15	tongs	tong	NOUN
dti-1318	208	16	.	.	PUNCT
dti-1318	209	1	cross	cross	ADJ
dti-1318	209	2	-	-	ADJ
dti-1318	209	3	linked	link	VERB
dti-1318	209	4	interfacial	interfacial	ADJ
dti-1318	209	5	peptides	peptide	NOUN
dti-1318	209	6	have	have	AUX
dti-1318	209	7	been	be	AUX
dti-1318	209	8	designed	design	VERB
dti-1318	209	9	to	to	PART
dti-1318	209	10	irreversibly	irreversibly	ADV
dti-1318	209	11	inhibit	inhibit	VERB
dti-1318	209	12	hiv-1	hiv-1	PUNCT
dti-1318	209	13	pr	pr	NOUN
dti-1318	209	14	by	by	ADP
dti-1318	209	15	formation	formation	NOUN
dti-1318	209	16	of	of	ADP
dti-1318	209	17	a	a	DET
dti-1318	209	18	disulfi	disulfi	NOUN
dti-1318	209	19	de	de	X
dti-1318	209	20	bond	bond	NOUN
dti-1318	209	21	between	between	ADP
dti-1318	209	22	the	the	DET
dti-1318	209	23	peptide	peptide	NOUN
dti-1318	209	24	and	and	CCONJ
dti-1318	209	25	the	the	DET
dti-1318	209	26	conserved	conserve	VERB
dti-1318	209	27	pr	pr	NOUN
dti-1318	209	28	residues	residue	NOUN
dti-1318	209	29	c-95	c-95	NOUN
dti-1318	209	30	and	and	CCONJ
dti-1318	209	31	c-67	c-67	X
dti-1318	209	32	,	,	PUNCT
dti-1318	209	33	and	and	CCONJ
dti-1318	209	34	demonstrate	demonstrate	VERB
dti-1318	209	35	a	a	DET
dti-1318	209	36	ki	ki	PROPN
dti-1318	209	37	in	in	ADP
dti-1318	209	38	the	the	DET
dti-1318	209	39	low	low	ADJ
dti-1318	209	40	micromolar	micromolar	ADJ
dti-1318	209	41	range	range	NOUN
dti-1318	209	42	(	(	PUNCT
dti-1318	209	43	zutshi	zutshi	NOUN
dti-1318	209	44	and	and	CCONJ
dti-1318	209	45	chmielewski	chmielewski	ADJ
dti-1318	209	46	,	,	PUNCT
dti-1318	209	47	2000	2000	NUM
dti-1318	209	48	)	)	PUNCT
dti-1318	209	49	.	.	PUNCT
dti-1318	210	1	the	the	DET
dti-1318	210	2	c	c	NOUN
dti-1318	210	3	-	-	PUNCT
dti-1318	210	4	terminal	terminal	ADJ
dti-1318	210	5	tetrapeptide	tetrapeptide	NOUN
dti-1318	210	6	has	have	AUX
dti-1318	210	7	also	also	ADV
dti-1318	210	8	been	be	AUX
dti-1318	210	9	tethered	tether	VERB
dti-1318	210	10	to	to	ADP
dti-1318	210	11	a	a	DET
dti-1318	210	12	peptidic	peptidic	ADJ
dti-1318	210	13	pr	pr	NOUN
dti-1318	210	14	active	active	ADJ
dti-1318	210	15	site	site	NOUN
dti-1318	210	16	inhibitor	inhibitor	NOUN
dti-1318	210	17	,	,	PUNCT
dti-1318	210	18	combining	combine	VERB
dti-1318	210	19	both	both	CCONJ
dti-1318	210	20	dissociative	dissociative	ADJ
dti-1318	210	21	and	and	CCONJ
dti-1318	210	22	competitive	competitive	ADJ
dti-1318	210	23	methods	method	NOUN
dti-1318	210	24	of	of	ADP
dti-1318	210	25	inhibition	inhibition	NOUN
dti-1318	210	26	in	in	ADP
dti-1318	210	27	one	one	NUM
dti-1318	210	28	molecule	molecule	NOUN
dti-1318	210	29	(	(	PUNCT
dti-1318	210	30	uhlikova	uhlikova	PROPN
dti-1318	210	31	et	et	PROPN
dti-1318	210	32	al	al	PROPN
dti-1318	210	33	.	.	PROPN
dti-1318	210	34	1996	1996	NUM
dti-1318	210	35	)	)	PUNCT
dti-1318	210	36	.	.	PUNCT
dti-1318	211	1	random	random	ADJ
dti-1318	211	2	peptides	peptide	NOUN
dti-1318	211	3	that	that	PRON
dti-1318	211	4	are	be	AUX
dti-1318	211	5	dissociative	dissociative	ADJ
dti-1318	211	6	inhibitors	inhibitor	NOUN
dti-1318	211	7	of	of	ADP
dti-1318	211	8	hiv-1	hiv-1	X
dti-1318	211	9	pr	pr	NOUN
dti-1318	211	10	have	have	AUX
dti-1318	211	11	been	be	AUX
dti-1318	211	12	described	describe	VERB
dti-1318	211	13	.	.	PUNCT
dti-1318	212	1	the	the	DET
dti-1318	212	2	bacteriophage	bacteriophage	NOUN
dti-1318	212	3	lambda	lambda	NOUN
dti-1318	212	4	repressor	repressor	NOUN
dti-1318	212	5	protein	protein	NOUN
dti-1318	212	6	was	be	AUX
dti-1318	212	7	utilised	utilise	VERB
dti-1318	212	8	to	to	PART
dti-1318	212	9	develop	develop	VERB
dti-1318	212	10	a	a	DET
dti-1318	212	11	powerful	powerful	ADJ
dti-1318	212	12	two	two	NUM
dti-1318	212	13	-	-	PUNCT
dti-1318	212	14	hybrid	hybrid	ADJ
dti-1318	212	15	pr	pr	NOUN
dti-1318	212	16	dimerization	dimerization	NOUN
dti-1318	212	17	assay	assay	VERB
dti-1318	212	18	.	.	PUNCT
dti-1318	213	1	from	from	ADP
dti-1318	213	2	a	a	DET
dti-1318	213	3	library	library	NOUN
dti-1318	213	4	of	of	ADP
dti-1318	213	5	5	5	NUM
dti-1318	213	6	×	×	NOUN
dti-1318	213	7	108	108	NUM
dti-1318	213	8	random	random	ADJ
dti-1318	213	9	peptides	peptide	NOUN
dti-1318	213	10	,	,	PUNCT
dti-1318	213	11	300	300	NUM
dti-1318	213	12	were	be	AUX
dti-1318	213	13	identifi	identifi	PROPN
dti-1318	213	14	ed	ed	NOUN
dti-1318	213	15	as	as	ADP
dti-1318	213	16	potential	potential	ADJ
dti-1318	213	17	pr	pr	NOUN
dti-1318	213	18	dimerization	dimerization	NOUN
dti-1318	213	19	inhibitors	inhibitor	NOUN
dti-1318	213	20	.	.	PUNCT
dti-1318	214	1	the	the	DET
dti-1318	214	2	most	most	ADV
dti-1318	214	3	potent	potent	ADJ
dti-1318	214	4	peptide	peptide	NOUN
dti-1318	214	5	identifi	identifi	PROPN
dti-1318	214	6	ed	ed	NOUN
dti-1318	214	7	,	,	PUNCT
dti-1318	214	8	p52	p52	NOUN
dti-1318	214	9	,	,	PUNCT
dti-1318	214	10	was	be	AUX
dti-1318	214	11	a	a	DET
dti-1318	214	12	pure	pure	ADJ
dti-1318	214	13	dissociative	dissociative	ADJ
dti-1318	214	14	inhibitor	inhibitor	NOUN
dti-1318	214	15	with	with	ADP
dti-1318	214	16	low	low	ADJ
dti-1318	214	17	ki	ki	PROPN
dti-1318	214	18	of	of	ADP
dti-1318	214	19	780	780	NUM
dti-1318	214	20	nm	nm	NOUN
dti-1318	214	21	(	(	PUNCT
dti-1318	214	22	park	park	NOUN
dti-1318	214	23	and	and	CCONJ
dti-1318	214	24	raines	raine	NOUN
dti-1318	214	25	,	,	PUNCT
dti-1318	214	26	2000	2000	NUM
dti-1318	214	27	)	)	PUNCT
dti-1318	214	28	.	.	PUNCT
dti-1318	215	1	ultimately	ultimately	ADV
dti-1318	215	2	,	,	PUNCT
dti-1318	215	3	one	one	NUM
dti-1318	215	4	of	of	ADP
dti-1318	215	5	the	the	DET
dti-1318	215	6	major	major	ADJ
dti-1318	215	7	hurdles	hurdle	NOUN
dti-1318	215	8	in	in	ADP
dti-1318	215	9	developing	develop	VERB
dti-1318	215	10	peptidic	peptidic	ADJ
dti-1318	215	11	inhibitors	inhibitor	NOUN
dti-1318	215	12	is	be	AUX
dti-1318	215	13	to	to	PART
dti-1318	215	14	obtain	obtain	VERB
dti-1318	215	15	a	a	DET
dti-1318	215	16	biologically	biologically	ADV
dti-1318	215	17	stable	stable	ADJ
dti-1318	215	18	compound	compound	NOUN
dti-1318	215	19	that	that	PRON
dti-1318	215	20	can	can	AUX
dti-1318	215	21	be	be	AUX
dti-1318	215	22	delivered	deliver	VERB
dti-1318	215	23	inside	inside	ADP
dti-1318	215	24	the	the	DET
dti-1318	215	25	cell	cell	NOUN
dti-1318	215	26	.	.	PUNCT
dti-1318	216	1	one	one	NUM
dti-1318	216	2	mechanism	mechanism	NOUN
dti-1318	216	3	to	to	PART
dti-1318	216	4	achieve	achieve	VERB
dti-1318	216	5	this	this	PRON
dti-1318	216	6	is	be	AUX
dti-1318	216	7	to	to	PART
dti-1318	216	8	fuse	fuse	VERB
dti-1318	216	9	the	the	DET
dti-1318	216	10	peptide	peptide	NOUN
dti-1318	216	11	to	to	ADP
dti-1318	216	12	amino	amino	NOUN
dti-1318	216	13	acid	acid	NOUN
dti-1318	216	14	sequences	sequence	NOUN
dti-1318	216	15	that	that	PRON
dti-1318	216	16	promote	promote	VERB
dti-1318	216	17	either	either	DET
dti-1318	216	18	encapsidation	encapsidation	NOUN
dti-1318	216	19	into	into	ADP
dti-1318	216	20	viral	viral	ADJ
dti-1318	216	21	particles	particle	NOUN
dti-1318	216	22	or	or	CCONJ
dti-1318	216	23	entry	entry	NOUN
dti-1318	216	24	into	into	ADP
dti-1318	216	25	the	the	DET
dti-1318	216	26	host	host	NOUN
dti-1318	216	27	cell	cell	NOUN
dti-1318	216	28	.	.	PUNCT
dti-1318	217	1	virus	virus	NOUN
dti-1318	217	2	protein	protein	NOUN
dti-1318	217	3	r	r	NOUN
dti-1318	217	4	(	(	PUNCT
dti-1318	217	5	vpr	vpr	NOUN
dti-1318	217	6	)	)	PUNCT
dti-1318	217	7	is	be	AUX
dti-1318	217	8	a	a	DET
dti-1318	217	9	hiv-1	hiv-1	X
dti-1318	217	10	accessory	accessory	ADJ
dti-1318	217	11	protein	protein	NOUN
dti-1318	217	12	packaged	package	VERB
dti-1318	217	13	into	into	ADP
dti-1318	217	14	virions	virion	NOUN
dti-1318	217	15	by	by	ADP
dti-1318	217	16	its	its	PRON
dti-1318	217	17	trans	trans	PROPN
dti-1318	217	18	association	association	NOUN
dti-1318	217	19	with	with	ADP
dti-1318	217	20	the	the	DET
dti-1318	217	21	gag	gag	NOUN
dti-1318	217	22	p6	p6	NOUN
dti-1318	217	23	motif	motif	NOUN
dti-1318	217	24	.	.	PUNCT
dti-1318	218	1	both	both	DET
dti-1318	218	2	viral	viral	ADJ
dti-1318	218	3	and	and	CCONJ
dti-1318	218	4	cellular	cellular	ADJ
dti-1318	218	5	proteins	protein	NOUN
dti-1318	218	6	have	have	AUX
dti-1318	218	7	been	be	AUX
dti-1318	218	8	successfully	successfully	ADV
dti-1318	218	9	delivered	deliver	VERB
dti-1318	218	10	into	into	ADP
dti-1318	218	11	viral	viral	ADJ
dti-1318	218	12	particles	particle	NOUN
dti-1318	218	13	as	as	ADP
dti-1318	218	14	vpr	vpr	NOUN
dti-1318	218	15	fusion	fusion	NOUN
dti-1318	218	16	proteins	protein	NOUN
dti-1318	218	17	(	(	PUNCT
dti-1318	218	18	wu	wu	PROPN
dti-1318	218	19	et	et	PROPN
dti-1318	218	20	al	al	PROPN
dti-1318	218	21	.	.	PROPN
dti-1318	218	22	1997	1997	NUM
dti-1318	218	23	)	)	PUNCT
dti-1318	218	24	.	.	PUNCT
dti-1318	219	1	inhibition	inhibition	NOUN
dti-1318	219	2	of	of	ADP
dti-1318	219	3	hiv-1	hiv-1	X
dti-1318	219	4	replication	replication	NOUN
dti-1318	219	5	has	have	AUX
dti-1318	219	6	been	be	AUX
dti-1318	219	7	reported	report	VERB
dti-1318	219	8	by	by	ADP
dti-1318	219	9	the	the	DET
dti-1318	219	10	fusion	fusion	NOUN
dti-1318	219	11	of	of	ADP
dti-1318	219	12	vpr	vpr	NOUN
dti-1318	219	13	to	to	ADP
dti-1318	219	14	viral	viral	ADJ
dti-1318	219	15	pr	pr	NOUN
dti-1318	219	16	recognition	recognition	NOUN
dti-1318	219	17	sequences	sequence	NOUN
dti-1318	219	18	(	(	PUNCT
dti-1318	219	19	serio	serio	PROPN
dti-1318	219	20	et	et	PROPN
dti-1318	219	21	al	al	PROPN
dti-1318	219	22	.	.	PROPN
dti-1318	219	23	2000	2000	NUM
dti-1318	219	24	)	)	PUNCT
dti-1318	219	25	.	.	PUNCT
dti-1318	220	1	expression	expression	NOUN
dti-1318	220	2	of	of	ADP
dti-1318	220	3	the	the	DET
dti-1318	220	4	pr	pr	NOUN
dti-1318	220	5	c	c	NOUN
dti-1318	220	6	-	-	PUNCT
dti-1318	220	7	terminal	terminal	ADJ
dti-1318	220	8	tetrapeptide	tetrapeptide	ADV
dti-1318	220	9	as	as	ADP
dti-1318	220	10	a	a	DET
dti-1318	220	11	vpr	vpr	NOUN
dti-1318	220	12	fusion	fusion	NOUN
dti-1318	221	1	[	[	X
dti-1318	221	2	vpr-(spacer)-t	vpr-(spacer)-t	PROPN
dti-1318	221	3	-	-	PUNCT
dti-1318	221	4	l	l	NOUN
dti-1318	221	5	-	-	PUNCT
dti-1318	221	6	n	n	CCONJ
dti-1318	221	7	-	-	PUNCT
dti-1318	221	8	f	f	NOUN
dti-1318	221	9	-	-	PUNCT
dti-1318	221	10	oh	oh	NOUN
dti-1318	221	11	]	]	PUNCT
dti-1318	221	12	attenuates	attenuate	VERB
dti-1318	221	13	hiv-1	hiv-1	X
dti-1318	221	14	replication	replication	NOUN
dti-1318	221	15	in	in	ADP
dti-1318	221	16	chronically	chronically	ADV
dti-1318	221	17	infected	infect	VERB
dti-1318	221	18	cells	cell	NOUN
dti-1318	221	19	and	and	CCONJ
dti-1318	221	20	in	in	ADP
dti-1318	221	21	single	single	ADJ
dti-1318	221	22	-	-	PUNCT
dti-1318	221	23	round	round	NOUN
dti-1318	221	24	replication	replication	NOUN
dti-1318	221	25	assays	assay	NOUN
dti-1318	221	26	(	(	PUNCT
dti-1318	221	27	cartas	carta	NOUN
dti-1318	221	28	et	et	PROPN
dti-1318	221	29	al	al	PROPN
dti-1318	221	30	.	.	PROPN
dti-1318	221	31	2001	2001	NUM
dti-1318	221	32	)	)	PUNCT
dti-1318	221	33	.	.	PUNCT
dti-1318	222	1	most	most	ADV
dti-1318	222	2	recently	recently	ADV
dti-1318	222	3	,	,	PUNCT
dti-1318	222	4	inhibition	inhibition	NOUN
dti-1318	222	5	of	of	ADP
dti-1318	222	6	hiv-1	hiv-1	X
dti-1318	222	7	replication	replication	NOUN
dti-1318	222	8	has	have	AUX
dti-1318	222	9	been	be	AUX
dti-1318	222	10	demonstrated	demonstrate	VERB
dti-1318	222	11	by	by	ADP
dti-1318	222	12	delivering	deliver	VERB
dti-1318	222	13	pr	pr	NOUN
dti-1318	222	14	interface	interface	NOUN
dti-1318	222	15	peptides	peptide	NOUN
dti-1318	222	16	as	as	ADP
dti-1318	222	17	a	a	DET
dti-1318	222	18	fusion	fusion	NOUN
dti-1318	222	19	peptide	peptide	NOUN
dti-1318	222	20	utilising	utilise	VERB
dti-1318	222	21	the	the	DET
dti-1318	222	22	hiv-1	hiv-1	ADJ
dti-1318	222	23	tat	tat	ADJ
dti-1318	222	24	derived	derive	VERB
dti-1318	222	25	cell	cell	NOUN
dti-1318	222	26	permeable	permeable	ADJ
dti-1318	222	27	protein	protein	NOUN
dti-1318	222	28	transduction	transduction	NOUN
dti-1318	222	29	domain	domain	NOUN
dti-1318	222	30	figure	figure	NOUN
dti-1318	222	31	2	2	NUM
dti-1318	222	32	.	.	PUNCT
dti-1318	223	1	a	a	DET
dti-1318	223	2	molecular	molecular	ADJ
dti-1318	223	3	tong	tong	NOUN
dti-1318	223	4	bound	bind	VERB
dti-1318	223	5	to	to	ADP
dti-1318	223	6	the	the	DET
dti-1318	223	7	c	c	NOUN
dti-1318	223	8	-	-	PUNCT
dti-1318	223	9	terminus	terminus	NOUN
dti-1318	223	10	of	of	ADP
dti-1318	223	11	the	the	DET
dti-1318	223	12	hiv-1	hiv-1	X
dti-1318	223	13	pr	pr	NOUN
dti-1318	223	14	monomer	monomer	NOUN
dti-1318	223	15	.	.	PUNCT
dti-1318	224	1	169	169	NUM
dti-1318	224	2	targeting	target	VERB
dti-1318	224	3	the	the	DET
dti-1318	224	4	late	late	ADJ
dti-1318	224	5	stages	stage	NOUN
dti-1318	224	6	of	of	ADP
dti-1318	224	7	hiv-1	hiv-1	X
dti-1318	224	8	replication	replication	NOUN
dti-1318	224	9	drug	drug	NOUN
dti-1318	224	10	target	target	NOUN
dti-1318	224	11	insights	insight	NOUN
dti-1318	224	12	2007	2007	NUM
dti-1318	224	13	:	:	SYM
dti-1318	224	14	2	2	NUM
dti-1318	224	15	(	(	PUNCT
dti-1318	224	16	davis	davis	PROPN
dti-1318	224	17	et	et	PROPN
dti-1318	224	18	al	al	PROPN
dti-1318	224	19	.	.	PROPN
dti-1318	224	20	2006	2006	NUM
dti-1318	224	21	)	)	PUNCT
dti-1318	224	22	.	.	PUNCT
dti-1318	225	1	peptides	peptide	NOUN
dti-1318	225	2	p27	p27	PROPN
dti-1318	225	3	/	/	SYM
dti-1318	225	4	a	a	PRON
dti-1318	225	5	are	be	AUX
dti-1318	225	6	pr	pr	NOUN
dti-1318	225	7	dimerization	dimerization	NOUN
dti-1318	225	8	inhibitors	inhibitor	NOUN
dti-1318	225	9	that	that	PRON
dti-1318	225	10	inhibit	inhibit	VERB
dti-1318	225	11	the	the	DET
dti-1318	225	12	activity	activity	NOUN
dti-1318	225	13	of	of	ADP
dti-1318	225	14	wild	wild	ADJ
dti-1318	225	15	-	-	PUNCT
dti-1318	225	16	type	type	NOUN
dti-1318	225	17	and	and	CCONJ
dti-1318	225	18	drug	drug	NOUN
dti-1318	225	19	resistant	resistant	ADJ
dti-1318	225	20	pr	pr	NOUN
dti-1318	225	21	in	in	ADP
dti-1318	225	22	cell	cell	NOUN
dti-1318	225	23	free	free	ADJ
dti-1318	225	24	assays	assay	NOUN
dti-1318	225	25	with	with	ADP
dti-1318	225	26	ic50	ic50	PROPN
dti-1318	225	27	values	value	NOUN
dti-1318	225	28	in	in	ADP
dti-1318	225	29	the	the	DET
dti-1318	225	30	0.28–0.58	0.28–0.58	NUM
dti-1318	225	31	µm	µm	ADP
dti-1318	225	32	range	range	NOUN
dti-1318	225	33	.	.	PUNCT
dti-1318	226	1	these	these	DET
dti-1318	226	2	peptides	peptide	NOUN
dti-1318	226	3	are	be	AUX
dti-1318	226	4	successfully	successfully	ADV
dti-1318	226	5	delivered	deliver	VERB
dti-1318	226	6	into	into	ADP
dti-1318	226	7	chronically	chronically	ADV
dti-1318	226	8	hiv-1	hiv-1	PUNCT
dti-1318	226	9	infected	infect	VERB
dti-1318	226	10	cells	cell	NOUN
dti-1318	226	11	and	and	CCONJ
dti-1318	226	12	reduce	reduce	VERB
dti-1318	226	13	viral	viral	ADJ
dti-1318	226	14	particle	particle	NOUN
dti-1318	226	15	production	production	NOUN
dti-1318	226	16	.	.	PUNCT
dti-1318	227	1	this	this	PRON
dti-1318	227	2	was	be	AUX
dti-1318	227	3	observed	observe	VERB
dti-1318	227	4	by	by	ADP
dti-1318	227	5	a	a	DET
dti-1318	227	6	reduction	reduction	NOUN
dti-1318	227	7	in	in	ADP
dti-1318	227	8	p24	p24	NOUN
dti-1318	227	9	,	,	PUNCT
dti-1318	227	10	rather	rather	ADV
dti-1318	227	11	than	than	ADP
dti-1318	227	12	inhibition	inhibition	NOUN
dti-1318	227	13	of	of	ADP
dti-1318	227	14	gag	gag	NOUN
dti-1318	227	15	processing	processing	NOUN
dti-1318	227	16	which	which	PRON
dti-1318	227	17	suggests	suggest	VERB
dti-1318	227	18	that	that	SCONJ
dti-1318	227	19	the	the	DET
dti-1318	227	20	peptide	peptide	NOUN
dti-1318	227	21	may	may	AUX
dti-1318	227	22	interact	interact	VERB
dti-1318	227	23	with	with	ADP
dti-1318	227	24	the	the	DET
dti-1318	227	25	gag	gag	NOUN
dti-1318	227	26	-	-	PUNCT
dti-1318	227	27	pol	pol	NOUN
dti-1318	227	28	embedded	embed	VERB
dti-1318	227	29	pr	pr	NOUN
dti-1318	227	30	and	and	CCONJ
dti-1318	227	31	disrupt	disrupt	VERB
dti-1318	227	32	the	the	DET
dti-1318	227	33	ordered	order	VERB
dti-1318	227	34	processing	processing	NOUN
dti-1318	227	35	of	of	ADP
dti-1318	227	36	gag	gag	NOUN
dti-1318	227	37	-	-	PUNCT
dti-1318	227	38	pol	pol	NOUN
dti-1318	227	39	leading	lead	VERB
dti-1318	227	40	a	a	DET
dti-1318	227	41	decrease	decrease	NOUN
dti-1318	227	42	in	in	ADP
dti-1318	227	43	viral	viral	ADJ
dti-1318	227	44	particle	particle	NOUN
dti-1318	227	45	production	production	NOUN
dti-1318	227	46	(	(	PUNCT
dti-1318	227	47	davis	davis	PROPN
dti-1318	227	48	et	et	PROPN
dti-1318	227	49	al	al	PROPN
dti-1318	227	50	.	.	PROPN
dti-1318	227	51	2006	2006	NUM
dti-1318	227	52	)	)	PUNCT
dti-1318	227	53	.	.	PUNCT
dti-1318	228	1	pr	pr	AUX
dti-1318	228	2	folding	fold	VERB
dti-1318	228	3	inhibitors	inhibitor	NOUN
dti-1318	228	4	local	local	ADJ
dti-1318	228	5	elementary	elementary	ADJ
dti-1318	228	6	structures	structure	NOUN
dti-1318	228	7	(	(	PUNCT
dti-1318	228	8	les	le	NOUN
dti-1318	228	9	)	)	PUNCT
dti-1318	228	10	are	be	AUX
dti-1318	228	11	comprised	comprise	VERB
dti-1318	228	12	of	of	ADP
dti-1318	228	13	strongly	strongly	ADV
dti-1318	228	14	interacting	interact	VERB
dti-1318	228	15	,	,	PUNCT
dti-1318	228	16	highly	highly	ADV
dti-1318	228	17	conserved	conserved	ADJ
dti-1318	228	18	amino	amino	ADJ
dti-1318	228	19	acids	acid	NOUN
dti-1318	228	20	that	that	PRON
dti-1318	228	21	are	be	AUX
dti-1318	228	22	usually	usually	ADV
dti-1318	228	23	hydrophobic	hydrophobic	ADJ
dti-1318	228	24	.	.	PUNCT
dti-1318	229	1	these	these	DET
dti-1318	229	2	amino	amino	ADJ
dti-1318	229	3	acids	acid	NOUN
dti-1318	229	4	are	be	AUX
dti-1318	229	5	suggested	suggest	VERB
dti-1318	229	6	to	to	PART
dti-1318	229	7	direct	direct	VERB
dti-1318	229	8	the	the	DET
dti-1318	229	9	folding	folding	NOUN
dti-1318	229	10	of	of	ADP
dti-1318	229	11	a	a	DET
dti-1318	229	12	protein	protein	NOUN
dti-1318	229	13	into	into	ADP
dti-1318	229	14	its	its	PRON
dti-1318	229	15	native	native	ADJ
dti-1318	229	16	conformation	conformation	NOUN
dti-1318	229	17	.	.	PUNCT
dti-1318	230	1	short	short	ADJ
dti-1318	230	2	peptides	peptide	NOUN
dti-1318	230	3	corresponding	correspond	VERB
dti-1318	230	4	to	to	ADP
dti-1318	230	5	or	or	CCONJ
dti-1318	230	6	mimicking	mimic	VERB
dti-1318	230	7	the	the	DET
dti-1318	230	8	les	le	NOUN
dti-1318	230	9	are	be	AUX
dti-1318	230	10	hypothesised	hypothesise	VERB
dti-1318	230	11	to	to	PART
dti-1318	230	12	act	act	VERB
dti-1318	230	13	as	as	ADP
dti-1318	230	14	folding	fold	VERB
dti-1318	230	15	inhibitors	inhibitor	NOUN
dti-1318	230	16	,	,	PUNCT
dti-1318	230	17	preventing	prevent	VERB
dti-1318	230	18	the	the	DET
dti-1318	230	19	protein	protein	NOUN
dti-1318	230	20	achieving	achieve	VERB
dti-1318	230	21	its	its	PRON
dti-1318	230	22	native	native	ADJ
dti-1318	230	23	conformation	conformation	NOUN
dti-1318	230	24	(	(	PUNCT
dti-1318	230	25	broglia	broglia	PROPN
dti-1318	230	26	et	et	PROPN
dti-1318	230	27	al	al	PROPN
dti-1318	230	28	.	.	PROPN
dti-1318	230	29	2005	2005	NUM
dti-1318	230	30	)	)	PUNCT
dti-1318	230	31	.	.	PUNCT
dti-1318	231	1	a	a	DET
dti-1318	231	2	peptide	peptide	NOUN
dti-1318	231	3	has	have	AUX
dti-1318	231	4	been	be	AUX
dti-1318	231	5	identifi	identifi	PROPN
dti-1318	231	6	ed	ed	NOUN
dti-1318	231	7	from	from	ADP
dti-1318	231	8	a	a	DET
dti-1318	231	9	les	les	NOUN
dti-1318	231	10	in	in	ADP
dti-1318	231	11	the	the	DET
dti-1318	231	12	hiv-1	hiv-1	X
dti-1318	231	13	pr	pr	NOUN
dti-1318	231	14	(	(	PUNCT
dti-1318	231	15	peptide	peptide	NOUN
dti-1318	231	16	s8	s8	NOUN
dti-1318	231	17	,	,	PUNCT
dti-1318	231	18	amino	amino	NOUN
dti-1318	231	19	acids	acid	NOUN
dti-1318	231	20	83–93	83–93	NUM
dti-1318	231	21	)	)	PUNCT
dti-1318	231	22	that	that	PRON
dti-1318	231	23	inhibits	inhibit	VERB
dti-1318	231	24	pr	pr	NOUN
dti-1318	231	25	activity	activity	NOUN
dti-1318	231	26	with	with	ADP
dti-1318	231	27	a	a	DET
dti-1318	231	28	ki	ki	PROPN
dti-1318	231	29	of	of	ADP
dti-1318	231	30	2.58	2.58	NUM
dti-1318	231	31	µm	µm	NOUN
dti-1318	231	32	and	and	CCONJ
dti-1318	231	33	results	result	NOUN
dti-1318	231	34	in	in	ADP
dti-1318	231	35	disorganisation	disorganisation	NOUN
dti-1318	231	36	of	of	ADP
dti-1318	231	37	the	the	DET
dti-1318	231	38	pr	pr	ADJ
dti-1318	231	39	secondary	secondary	ADJ
dti-1318	231	40	structure	structure	NOUN
dti-1318	231	41	by	by	ADP
dti-1318	231	42	reducing	reduce	VERB
dti-1318	231	43	the	the	DET
dti-1318	231	44	β	β	NOUN
dti-1318	231	45	-	-	ADJ
dti-1318	231	46	sheet	sheet	NOUN
dti-1318	231	47	content	content	NOUN
dti-1318	231	48	from	from	ADP
dti-1318	231	49	30	30	NUM
dti-1318	231	50	%	%	NOUN
dti-1318	231	51	to	to	PART
dti-1318	231	52	14	14	NUM
dti-1318	231	53	%	%	NOUN
dti-1318	231	54	(	(	PUNCT
dti-1318	231	55	broglia	broglia	PROPN
dti-1318	231	56	et	et	PROPN
dti-1318	231	57	al	al	PROPN
dti-1318	231	58	.	.	PROPN
dti-1318	231	59	2005	2005	NUM
dti-1318	231	60	;	;	PUNCT
dti-1318	231	61	broglia	broglia	PROPN
dti-1318	231	62	et	et	PROPN
dti-1318	231	63	al	al	PROPN
dti-1318	231	64	.	.	PROPN
dti-1318	231	65	2006	2006	NUM
dti-1318	231	66	)	)	PUNCT
dti-1318	231	67	.	.	PUNCT
dti-1318	232	1	current	current	ADJ
dti-1318	232	2	efforts	effort	NOUN
dti-1318	232	3	are	be	AUX
dti-1318	232	4	directed	direct	VERB
dti-1318	232	5	towards	towards	ADP
dti-1318	232	6	developing	develop	VERB
dti-1318	232	7	a	a	DET
dti-1318	232	8	shorter	shorter	ADV
dti-1318	232	9	less	less	ADV
dti-1318	232	10	hydrophobic	hydrophobic	NOUN
dti-1318	232	11	peptide	peptide	NOUN
dti-1318	232	12	or	or	CCONJ
dti-1318	232	13	mimetic	mimetic	ADJ
dti-1318	232	14	based	base	VERB
dti-1318	232	15	on	on	ADP
dti-1318	232	16	the	the	DET
dti-1318	232	17	s8	s8	PROPN
dti-1318	232	18	lead	lead	NOUN
dti-1318	232	19	peptide	peptide	NOUN
dti-1318	232	20	.	.	PUNCT
dti-1318	233	1	catalytically	catalytically	ADV
dti-1318	233	2	inactive	inactive	ADJ
dti-1318	233	3	pr	pr	NOUN
dti-1318	233	4	subunits	subunit	NOUN
dti-1318	233	5	as	as	ADP
dti-1318	233	6	dominant	dominant	ADJ
dti-1318	233	7	negative	negative	ADJ
dti-1318	233	8	inhibitors	inhibitor	NOUN
dti-1318	233	9	of	of	ADP
dti-1318	233	10	pr	pr	NOUN
dti-1318	233	11	activity	activity	NOUN
dti-1318	233	12	catalytically	catalytically	ADV
dti-1318	233	13	inactive	inactive	ADJ
dti-1318	233	14	pr	pr	NOUN
dti-1318	233	15	monomers	monomer	NOUN
dti-1318	233	16	act	act	VERB
dti-1318	233	17	in	in	ADP
dti-1318	233	18	a	a	DET
dti-1318	233	19	dominant	dominant	ADJ
dti-1318	233	20	negative	negative	ADJ
dti-1318	233	21	fashion	fashion	NOUN
dti-1318	233	22	to	to	PART
dti-1318	233	23	inhibit	inhibit	VERB
dti-1318	233	24	wild	wild	ADJ
dti-1318	233	25	-	-	PUNCT
dti-1318	233	26	type	type	NOUN
dti-1318	233	27	hiv-1	hiv-1	PUNCT
dti-1318	233	28	pr	pr	NOUN
dti-1318	233	29	by	by	ADP
dti-1318	233	30	forming	form	VERB
dti-1318	233	31	inactive	inactive	ADJ
dti-1318	233	32	heterodimers	heterodimer	NOUN
dti-1318	233	33	in	in	ADP
dti-1318	233	34	recombinant	recombinant	ADJ
dti-1318	233	35	protein	protein	NOUN
dti-1318	233	36	assays	assay	NOUN
dti-1318	233	37	(	(	PUNCT
dti-1318	233	38	babe	babe	NOUN
dti-1318	233	39	and	and	CCONJ
dti-1318	233	40	craik	craik	NOUN
dti-1318	233	41	,	,	PUNCT
dti-1318	233	42	1991	1991	NUM
dti-1318	233	43	)	)	PUNCT
dti-1318	233	44	.	.	PUNCT
dti-1318	234	1	when	when	SCONJ
dti-1318	234	2	virus	virus	NOUN
dti-1318	234	3	expressing	express	VERB
dti-1318	234	4	a	a	DET
dti-1318	234	5	pr	pr	NOUN
dti-1318	234	6	active	active	ADJ
dti-1318	234	7	site	site	NOUN
dti-1318	234	8	mutation	mutation	NOUN
dti-1318	234	9	is	be	AUX
dti-1318	234	10	co	co	VERB
dti-1318	234	11	-	-	VERB
dti-1318	234	12	transfected	transfecte	VERB
dti-1318	234	13	with	with	ADP
dti-1318	234	14	wild	wild	ADJ
dti-1318	234	15	-	-	PUNCT
dti-1318	234	16	type	type	NOUN
dti-1318	234	17	hiv-1	hiv-1	NOUN
dti-1318	234	18	,	,	PUNCT
dti-1318	234	19	both	both	PRON
dti-1318	234	20	viral	viral	ADJ
dti-1318	234	21	replication	replication	NOUN
dti-1318	234	22	and	and	CCONJ
dti-1318	234	23	virus	virus	NOUN
dti-1318	234	24	infectivity	infectivity	NOUN
dti-1318	234	25	are	be	AUX
dti-1318	234	26	reduced	reduce	VERB
dti-1318	234	27	(	(	PUNCT
dti-1318	234	28	babe	babe	NOUN
dti-1318	234	29	et	et	PROPN
dti-1318	234	30	al	al	PROPN
dti-1318	234	31	.	.	PROPN
dti-1318	234	32	1995	1995	NUM
dti-1318	234	33	)	)	PUNCT
dti-1318	234	34	.	.	PUNCT
dti-1318	235	1	computer	computer	NOUN
dti-1318	235	2	modelling	modelling	NOUN
dti-1318	235	3	has	have	AUX
dti-1318	235	4	been	be	AUX
dti-1318	235	5	used	use	VERB
dti-1318	235	6	to	to	PART
dti-1318	235	7	successfully	successfully	ADV
dti-1318	235	8	design	design	VERB
dti-1318	235	9	an	an	DET
dti-1318	235	10	optimised	optimise	VERB
dti-1318	235	11	dominant	dominant	ADJ
dti-1318	235	12	-	-	PUNCT
dti-1318	235	13	negative	negative	ADJ
dti-1318	235	14	pr	pr	NOUN
dti-1318	235	15	expressing	express	VERB
dti-1318	235	16	d25k	d25k	NOUN
dti-1318	235	17	,	,	PUNCT
dti-1318	235	18	g49w	g49w	NOUN
dti-1318	235	19	and	and	CCONJ
dti-1318	235	20	i50w	i50w	NOUN
dti-1318	235	21	(	(	PUNCT
dti-1318	235	22	kww	kww	PROPN
dti-1318	235	23	)	)	PUNCT
dti-1318	236	1	(	(	PUNCT
dti-1318	236	2	mcphee	mcphee	NOUN
dti-1318	236	3	et	et	PROPN
dti-1318	236	4	al	al	PROPN
dti-1318	236	5	.	.	PROPN
dti-1318	236	6	1996	1996	NUM
dti-1318	236	7	)	)	PUNCT
dti-1318	236	8	,	,	PUNCT
dti-1318	236	9	which	which	PRON
dti-1318	236	10	also	also	ADV
dti-1318	236	11	reduces	reduce	VERB
dti-1318	236	12	viral	viral	ADJ
dti-1318	236	13	replication	replication	NOUN
dti-1318	236	14	and	and	CCONJ
dti-1318	236	15	infectivity	infectivity	NOUN
dti-1318	236	16	(	(	PUNCT
dti-1318	236	17	junker	junker	NOUN
dti-1318	236	18	et	et	PROPN
dti-1318	236	19	al	al	PROPN
dti-1318	236	20	.	.	PROPN
dti-1318	236	21	1996	1996	NUM
dti-1318	236	22	)	)	PUNCT
dti-1318	236	23	.	.	PUNCT
dti-1318	237	1	biochemical	biochemical	ADJ
dti-1318	237	2	studies	study	NOUN
dti-1318	237	3	on	on	ADP
dti-1318	237	4	recombinant	recombinant	ADJ
dti-1318	237	5	dominant	dominant	ADJ
dti-1318	237	6	negative	negative	ADJ
dti-1318	237	7	prs	prs	NOUN
dti-1318	237	8	confi	confi	PROPN
dti-1318	237	9	rm	rm	PROPN
dti-1318	237	10	that	that	SCONJ
dti-1318	237	11	the	the	DET
dti-1318	237	12	mechanism	mechanism	NOUN
dti-1318	237	13	of	of	ADP
dti-1318	237	14	action	action	NOUN
dti-1318	237	15	is	be	AUX
dti-1318	237	16	by	by	ADP
dti-1318	237	17	formation	formation	NOUN
dti-1318	237	18	of	of	ADP
dti-1318	237	19	inactive	inactive	ADJ
dti-1318	237	20	heterodimers	heterodimer	NOUN
dti-1318	237	21	(	(	PUNCT
dti-1318	237	22	rozzelle	rozzelle	NOUN
dti-1318	237	23	et	et	PROPN
dti-1318	237	24	al	al	PROPN
dti-1318	237	25	.	.	PROPN
dti-1318	237	26	2000	2000	NUM
dti-1318	237	27	)	)	PUNCT
dti-1318	237	28	.	.	PUNCT
dti-1318	238	1	interestingly	interestingly	ADV
dti-1318	238	2	,	,	PUNCT
dti-1318	238	3	the	the	DET
dti-1318	238	4	mutant	mutant	ADJ
dti-1318	238	5	prs	prs	NOUN
dti-1318	238	6	can	can	AUX
dti-1318	238	7	not	not	PART
dti-1318	238	8	homodimerize	homodimerize	VERB
dti-1318	238	9	and	and	CCONJ
dti-1318	238	10	they	they	PRON
dti-1318	238	11	fold	fold	VERB
dti-1318	238	12	only	only	ADV
dti-1318	238	13	when	when	SCONJ
dti-1318	238	14	expressed	express	VERB
dti-1318	238	15	with	with	ADP
dti-1318	238	16	wild	wild	ADJ
dti-1318	238	17	-	-	PUNCT
dti-1318	238	18	type	type	NOUN
dti-1318	238	19	pr	pr	NOUN
dti-1318	238	20	.	.	PUNCT
dti-1318	239	1	pr	pr	NOUN
dti-1318	239	2	heterodimers	heterodimer	NOUN
dti-1318	239	3	are	be	AUX
dti-1318	239	4	also	also	ADV
dti-1318	239	5	more	more	ADV
dti-1318	239	6	stable	stable	ADJ
dti-1318	239	7	that	that	SCONJ
dti-1318	239	8	the	the	DET
dti-1318	239	9	wild	wild	ADJ
dti-1318	239	10	-	-	PUNCT
dti-1318	239	11	type	type	NOUN
dti-1318	239	12	homodimer	homodimer	NOUN
dti-1318	239	13	(	(	PUNCT
dti-1318	239	14	rozzelle	rozzelle	NOUN
dti-1318	239	15	et	et	PROPN
dti-1318	239	16	al	al	PROPN
dti-1318	239	17	.	.	PROPN
dti-1318	239	18	2000	2000	NUM
dti-1318	239	19	)	)	PUNCT
dti-1318	239	20	.	.	PUNCT
dti-1318	240	1	hence	hence	ADV
dti-1318	240	2	inactive	inactive	ADJ
dti-1318	240	3	pr	pr	NOUN
dti-1318	240	4	heterodimers	heterodimer	NOUN
dti-1318	240	5	form	form	VERB
dti-1318	240	6	the	the	DET
dti-1318	240	7	dominant	dominant	ADJ
dti-1318	240	8	species	specie	NOUN
dti-1318	240	9	.	.	PUNCT
dti-1318	241	1	such	such	DET
dti-1318	241	2	a	a	DET
dti-1318	241	3	dominant	dominant	ADJ
dti-1318	241	4	negative	negative	ADJ
dti-1318	241	5	strategy	strategy	NOUN
dti-1318	241	6	for	for	ADP
dti-1318	241	7	the	the	DET
dti-1318	241	8	inhibition	inhibition	NOUN
dti-1318	241	9	of	of	ADP
dti-1318	241	10	hiv-1	hiv-1	PUNCT
dti-1318	241	11	pr	pr	NOUN
dti-1318	241	12	would	would	AUX
dti-1318	241	13	require	require	VERB
dti-1318	241	14	in	in	ADP
dti-1318	241	15	vivo	vivo	ADJ
dti-1318	241	16	delivery	delivery	NOUN
dti-1318	241	17	by	by	ADP
dti-1318	241	18	a	a	DET
dti-1318	241	19	genetherapy	genetherapy	NOUN
dti-1318	241	20	system	system	NOUN
dti-1318	241	21	,	,	PUNCT
dti-1318	241	22	the	the	DET
dti-1318	241	23	therapeutic	therapeutic	ADJ
dti-1318	241	24	use	use	NOUN
dti-1318	241	25	of	of	ADP
dti-1318	241	26	which	which	PRON
dti-1318	241	27	is	be	AUX
dti-1318	241	28	unlikely	unlikely	ADJ
dti-1318	241	29	in	in	ADP
dti-1318	241	30	the	the	DET
dti-1318	241	31	near	near	ADJ
dti-1318	241	32	future	future	NOUN
dti-1318	241	33	.	.	PUNCT
dti-1318	242	1	non	non	ADJ
dti-1318	242	2	-	-	ADJ
dti-1318	242	3	peptide	peptide	ADJ
dti-1318	242	4	inhibitors	inhibitor	NOUN
dti-1318	242	5	of	of	ADP
dti-1318	242	6	hiv-1	hiv-1	PUNCT
dti-1318	242	7	pr	pr	VERB
dti-1318	242	8	a	a	DET
dti-1318	242	9	screen	screen	NOUN
dti-1318	242	10	of	of	ADP
dti-1318	242	11	a	a	DET
dti-1318	242	12	crude	crude	ADJ
dti-1318	242	13	extract	extract	NOUN
dti-1318	242	14	from	from	ADP
dti-1318	242	15	the	the	DET
dti-1318	242	16	marine	marine	ADJ
dti-1318	242	17	organism	organism	NOUN
dti-1318	242	18	magenta	magenta	NOUN
dti-1318	242	19	ascidian	ascidian	PROPN
dti-1318	242	20	didemnum	didemnum	PROPN
dti-1318	242	21	identifi	identifi	PROPN
dti-1318	242	22	ed	ed	PROPN
dti-1318	242	23	two	two	NUM
dti-1318	242	24	didemnaketals	didemnaketal	NOUN
dti-1318	242	25	,	,	PUNCT
dti-1318	242	26	a	a	DET
dti-1318	242	27	(	(	PUNCT
dti-1318	242	28	a	a	DET
dti-1318	242	29	bicyclic	bicyclic	NOUN
dti-1318	242	30	ketal	ketal	NOUN
dti-1318	242	31	)	)	PUNCT
dti-1318	242	32	and	and	CCONJ
dti-1318	242	33	b	b	X
dti-1318	242	34	(	(	PUNCT
dti-1318	242	35	a	a	DET
dti-1318	242	36	linear	linear	ADJ
dti-1318	242	37	heptaprenoid	heptaprenoid	NOUN
dti-1318	242	38	)	)	PUNCT
dti-1318	242	39	,	,	PUNCT
dti-1318	242	40	that	that	PRON
dti-1318	242	41	inhibit	inhibit	VERB
dti-1318	242	42	hiv-1	hiv-1	X
dti-1318	242	43	pr	pr	NOUN
dti-1318	242	44	activity	activity	NOUN
dti-1318	242	45	with	with	ADP
dti-1318	242	46	ic50	ic50	PROPN
dti-1318	242	47	values	value	NOUN
dti-1318	242	48	of	of	ADP
dti-1318	242	49	2	2	NUM
dti-1318	242	50	µm	µm	NOUN
dti-1318	242	51	and	and	CCONJ
dti-1318	242	52	10	10	NUM
dti-1318	242	53	µm	µm	NOUN
dti-1318	242	54	,	,	PUNCT
dti-1318	242	55	respectively	respectively	ADV
dti-1318	242	56	(	(	PUNCT
dti-1318	242	57	potts	potts	PROPN
dti-1318	242	58	et	et	PROPN
dti-1318	242	59	al	al	PROPN
dti-1318	242	60	.	.	PROPN
dti-1318	242	61	1991	1991	NUM
dti-1318	242	62	)	)	PUNCT
dti-1318	242	63	.	.	PUNCT
dti-1318	243	1	these	these	DET
dti-1318	243	2	compounds	compound	NOUN
dti-1318	243	3	are	be	AUX
dti-1318	243	4	unsuitable	unsuitable	ADJ
dti-1318	243	5	drug	drug	NOUN
dti-1318	243	6	candidates	candidate	NOUN
dti-1318	243	7	,	,	PUNCT
dti-1318	243	8	but	but	CCONJ
dti-1318	243	9	have	have	AUX
dti-1318	243	10	given	give	VERB
dti-1318	243	11	rise	rise	NOUN
dti-1318	243	12	to	to	ADP
dti-1318	243	13	a	a	DET
dti-1318	243	14	novel	novel	ADJ
dti-1318	243	15	class	class	NOUN
dti-1318	243	16	of	of	ADP
dti-1318	243	17	pentaesters	pentaester	NOUN
dti-1318	243	18	,	,	PUNCT
dti-1318	243	19	the	the	DET
dti-1318	243	20	most	most	ADV
dti-1318	243	21	potent	potent	NOUN
dti-1318	243	22	of	of	ADP
dti-1318	243	23	which	which	PRON
dti-1318	243	24	is	be	AUX
dti-1318	243	25	a	a	DET
dti-1318	243	26	dissociative	dissociative	ADJ
dti-1318	243	27	inhibitor	inhibitor	NOUN
dti-1318	243	28	of	of	ADP
dti-1318	243	29	pr	pr	NOUN
dti-1318	243	30	with	with	ADP
dti-1318	243	31	a	a	DET
dti-1318	243	32	ki	ki	PROPN
dti-1318	243	33	of	of	ADP
dti-1318	243	34	2.1	2.1	NUM
dti-1318	243	35	µm	µm	NOUN
dti-1318	243	36	(	(	PUNCT
dti-1318	243	37	fan	fan	PROPN
dti-1318	243	38	et	et	PROPN
dti-1318	243	39	al	al	PROPN
dti-1318	243	40	.	.	PROPN
dti-1318	243	41	1998	1998	NUM
dti-1318	243	42	)	)	PUNCT
dti-1318	243	43	.	.	PUNCT
dti-1318	244	1	a	a	DET
dti-1318	244	2	novel	novel	ADJ
dti-1318	244	3	class	class	NOUN
dti-1318	244	4	of	of	ADP
dti-1318	244	5	pr	pr	NOUN
dti-1318	244	6	dimerization	dimerization	NOUN
dti-1318	244	7	inhibitors	inhibitor	NOUN
dti-1318	244	8	were	be	AUX
dti-1318	244	9	identifi	identifi	PROPN
dti-1318	244	10	ed	ed	NOUN
dti-1318	244	11	by	by	ADP
dti-1318	244	12	searching	search	VERB
dti-1318	244	13	the	the	DET
dti-1318	244	14	cambridge	cambridge	PROPN
dti-1318	244	15	structural	structural	ADJ
dti-1318	244	16	database	database	NOUN
dti-1318	244	17	for	for	ADP
dti-1318	244	18	pharmacophores	pharmacophore	NOUN
dti-1318	244	19	that	that	PRON
dti-1318	244	20	mimic	mimic	VERB
dti-1318	244	21	the	the	DET
dti-1318	244	22	action	action	NOUN
dti-1318	244	23	of	of	ADP
dti-1318	244	24	previously	previously	ADV
dti-1318	244	25	identified	identify	VERB
dti-1318	244	26	inhibitory	inhibitory	ADJ
dti-1318	244	27	interface	interface	NOUN
dti-1318	244	28	peptides	peptide	NOUN
dti-1318	244	29	(	(	PUNCT
dti-1318	244	30	quere	quere	X
dti-1318	244	31	et	et	PROPN
dti-1318	244	32	al	al	PROPN
dti-1318	244	33	.	.	PROPN
dti-1318	244	34	1996	1996	NUM
dti-1318	244	35	)	)	PUNCT
dti-1318	244	36	.	.	PUNCT
dti-1318	245	1	several	several	ADJ
dti-1318	245	2	triterpene	triterpene	ADJ
dti-1318	245	3	structures	structure	NOUN
dti-1318	245	4	were	be	AUX
dti-1318	245	5	identifi	identifi	NOUN
dti-1318	245	6	ed	ed	NOUN
dti-1318	245	7	,	,	PUNCT
dti-1318	245	8	of	of	ADP
dti-1318	245	9	which	which	PRON
dti-1318	245	10	ursolic	ursolic	ADJ
dti-1318	245	11	acid	acid	NOUN
dti-1318	245	12	acts	act	VERB
dti-1318	245	13	as	as	ADP
dti-1318	245	14	a	a	DET
dti-1318	245	15	dissociative	dissociative	ADJ
dti-1318	245	16	inhibitor	inhibitor	NOUN
dti-1318	245	17	of	of	ADP
dti-1318	245	18	pr	pr	NOUN
dti-1318	245	19	with	with	ADP
dti-1318	245	20	an	an	DET
dti-1318	245	21	ic50	ic50	PROPN
dti-1318	245	22	of	of	ADP
dti-1318	245	23	2	2	NUM
dti-1318	245	24	µm	µm	NOUN
dti-1318	245	25	.	.	PUNCT
dti-1318	246	1	it	it	PRON
dti-1318	246	2	has	have	AUX
dti-1318	246	3	been	be	AUX
dti-1318	246	4	suggested	suggest	VERB
dti-1318	246	5	that	that	SCONJ
dti-1318	246	6	triterpene	triterpene	NOUN
dti-1318	246	7	could	could	AUX
dti-1318	246	8	provide	provide	VERB
dti-1318	246	9	another	another	DET
dti-1318	246	10	basic	basic	ADJ
dti-1318	246	11	scaffold	scaffold	NOUN
dti-1318	246	12	for	for	ADP
dti-1318	246	13	building	build	VERB
dti-1318	246	14	more	more	ADV
dti-1318	246	15	effective	effective	ADJ
dti-1318	246	16	peptidomimetics	peptidomimetic	NOUN
dti-1318	246	17	.	.	PUNCT
dti-1318	247	1	interestingly	interestingly	ADV
dti-1318	247	2	,	,	PUNCT
dti-1318	247	3	another	another	DET
dti-1318	247	4	member	member	NOUN
dti-1318	247	5	of	of	ADP
dti-1318	247	6	the	the	DET
dti-1318	247	7	triterpene	triterpene	PROPN
dti-1318	247	8	family	family	NOUN
dti-1318	247	9	,	,	PUNCT
dti-1318	247	10	pa-457	pa-457	PROPN
dti-1318	247	11	,	,	PUNCT
dti-1318	247	12	acts	act	VERB
dti-1318	247	13	as	as	ADP
dti-1318	247	14	a	a	DET
dti-1318	247	15	novel	novel	ADJ
dti-1318	247	16	inhibitor	inhibitor	NOUN
dti-1318	247	17	of	of	ADP
dti-1318	247	18	hiv-1	hiv-1	X
dti-1318	247	19	maturation	maturation	NOUN
dti-1318	247	20	which	which	PRON
dti-1318	247	21	is	be	AUX
dti-1318	247	22	discussed	discuss	VERB
dti-1318	247	23	later	later	ADV
dti-1318	247	24	in	in	ADP
dti-1318	247	25	this	this	DET
dti-1318	247	26	review	review	NOUN
dti-1318	247	27	.	.	PUNCT
dti-1318	248	1	a	a	DET
dti-1318	248	2	β	β	ADJ
dti-1318	248	3	-	-	ADJ
dti-1318	248	4	sheet	sheet	ADJ
dti-1318	248	5	mimetic	mimetic	NOUN
dti-1318	248	6	was	be	AUX
dti-1318	248	7	tested	test	VERB
dti-1318	248	8	for	for	ADP
dti-1318	248	9	its	its	PRON
dti-1318	248	10	ability	ability	NOUN
dti-1318	248	11	to	to	PART
dti-1318	248	12	inhibit	inhibit	VERB
dti-1318	248	13	pr	pr	NOUN
dti-1318	248	14	homodimerization	homodimerization	NOUN
dti-1318	248	15	by	by	ADP
dti-1318	248	16	perturbation	perturbation	NOUN
dti-1318	248	17	of	of	ADP
dti-1318	248	18	β	β	ADJ
dti-1318	248	19	-	-	ADJ
dti-1318	248	20	sheet	sheet	NOUN
dti-1318	248	21	formation	formation	NOUN
dti-1318	248	22	(	(	PUNCT
dti-1318	248	23	song	song	NOUN
dti-1318	248	24	et	et	PROPN
dti-1318	248	25	al	al	PROPN
dti-1318	248	26	.	.	PROPN
dti-1318	248	27	2001	2001	NUM
dti-1318	248	28	)	)	PUNCT
dti-1318	248	29	.	.	PUNCT
dti-1318	249	1	the	the	DET
dti-1318	249	2	β	β	ADJ
dti-1318	249	3	-	-	ADJ
dti-1318	249	4	sheet	sheet	ADJ
dti-1318	249	5	mimetic	mimetic	NOUN
dti-1318	249	6	had	have	VERB
dti-1318	249	7	a	a	DET
dti-1318	249	8	relatively	relatively	ADV
dti-1318	249	9	high	high	ADJ
dti-1318	249	10	ic50	ic50	PROPN
dti-1318	249	11	of	of	ADP
dti-1318	249	12	30	30	NUM
dti-1318	249	13	µm	µm	NOUN
dti-1318	249	14	and	and	CCONJ
dti-1318	249	15	the	the	DET
dti-1318	249	16	method	method	NOUN
dti-1318	249	17	of	of	ADP
dti-1318	249	18	inhibition	inhibition	NOUN
dti-1318	249	19	appears	appear	VERB
dti-1318	249	20	to	to	PART
dti-1318	249	21	be	be	AUX
dti-1318	249	22	complex	complex	ADJ
dti-1318	249	23	,	,	PUNCT
dti-1318	249	24	however	however	ADV
dti-1318	249	25	the	the	DET
dti-1318	249	26	structure	structure	NOUN
dti-1318	249	27	provides	provide	VERB
dti-1318	249	28	a	a	DET
dti-1318	249	29	non	non	ADJ
dti-1318	249	30	-	-	ADJ
dti-1318	249	31	peptidic	peptidic	ADJ
dti-1318	249	32	lead	lead	NOUN
dti-1318	249	33	compound	compound	NOUN
dti-1318	249	34	for	for	ADP
dti-1318	249	35	pr	pr	NOUN
dti-1318	249	36	inhibitors	inhibitor	NOUN
dti-1318	249	37	.	.	PUNCT
dti-1318	250	1	targeting	target	VERB
dti-1318	250	2	gag	gag	NOUN
dti-1318	250	3	processing	process	VERB
dti-1318	250	4	the	the	DET
dti-1318	250	5	rate	rate	NOUN
dti-1318	250	6	and	and	CCONJ
dti-1318	250	7	the	the	DET
dti-1318	250	8	specifi	specifi	PROPN
dti-1318	250	9	city	city	PROPN
dti-1318	250	10	of	of	ADP
dti-1318	250	11	gag	gag	NOUN
dti-1318	250	12	cleavage	cleavage	NOUN
dti-1318	250	13	by	by	ADP
dti-1318	250	14	the	the	DET
dti-1318	250	15	hiv-1	hiv-1	X
dti-1318	250	16	pr	pr	NOUN
dti-1318	250	17	is	be	AUX
dti-1318	250	18	dependent	dependent	ADJ
dti-1318	250	19	on	on	ADP
dti-1318	250	20	the	the	DET
dti-1318	250	21	amino	amino	NOUN
dti-1318	250	22	acid	acid	NOUN
dti-1318	250	23	composition	composition	NOUN
dti-1318	250	24	of	of	ADP
dti-1318	250	25	the	the	DET
dti-1318	250	26	different	different	ADJ
dti-1318	250	27	cleavage	cleavage	NOUN
dti-1318	250	28	sites	site	NOUN
dti-1318	250	29	recognized	recognize	VERB
dti-1318	250	30	by	by	ADP
dti-1318	250	31	the	the	DET
dti-1318	250	32	viral	viral	ADJ
dti-1318	250	33	pr	pr	NOUN
dti-1318	250	34	(	(	PUNCT
dti-1318	250	35	swanstrom	swanstrom	NOUN
dti-1318	250	36	,	,	PUNCT
dti-1318	250	37	1997	1997	NUM
dti-1318	250	38	)	)	PUNCT
dti-1318	250	39	.	.	PUNCT
dti-1318	251	1	based	base	VERB
dti-1318	251	2	on	on	ADP
dti-1318	251	3	the	the	DET
dti-1318	251	4	order	order	NOUN
dti-1318	251	5	of	of	ADP
dti-1318	251	6	proteolysis	proteolysis	NOUN
dti-1318	251	7	by	by	ADP
dti-1318	251	8	hiv-1	hiv-1	PUNCT
dti-1318	251	9	pr	pr	NOUN
dti-1318	251	10	,	,	PUNCT
dti-1318	251	11	these	these	DET
dti-1318	251	12	sites	site	NOUN
dti-1318	251	13	are	be	AUX
dti-1318	251	14	classified	classify	VERB
dti-1318	251	15	as	as	ADP
dti-1318	251	16	primary	primary	ADJ
dti-1318	251	17	(	(	PUNCT
dti-1318	251	18	p2	p2	PROPN
dti-1318	251	19	/	/	SYM
dti-1318	251	20	nc	nc	PROPN
dti-1318	251	21	)	)	PUNCT
dti-1318	251	22	,	,	PUNCT
dti-1318	251	23	secondary	secondary	ADJ
dti-1318	251	24	(	(	PUNCT
dti-1318	251	25	ma	ma	PROPN
dti-1318	251	26	/	/	SYM
dti-1318	251	27	ca	ca	PROPN
dti-1318	251	28	and	and	CCONJ
dti-1318	251	29	p1	p1	PROPN
dti-1318	251	30	/	/	SYM
dti-1318	251	31	p6	p6	PROPN
dti-1318	251	32	)	)	PUNCT
dti-1318	251	33	or	or	CCONJ
dti-1318	251	34	tertiary	tertiary	ADJ
dti-1318	251	35	(	(	PUNCT
dti-1318	251	36	ca	ca	NOUN
dti-1318	251	37	/	/	SYM
dti-1318	251	38	p2	p2	PROPN
dti-1318	251	39	170	170	NUM
dti-1318	251	40	wapling	waple	VERB
dti-1318	251	41	et	et	PROPN
dti-1318	251	42	al	al	PROPN
dti-1318	251	43	drug	drug	PROPN
dti-1318	251	44	target	target	NOUN
dti-1318	251	45	insights	insight	NOUN
dti-1318	251	46	2007	2007	NUM
dti-1318	251	47	:	:	SYM
dti-1318	251	48	2	2	NUM
dti-1318	251	49	or	or	CCONJ
dti-1318	251	50	ca	ca	NOUN
dti-1318	251	51	/	/	PUNCT
dti-1318	251	52	sp2	sp2	NOUN
dti-1318	251	53	)	)	PUNCT
dti-1318	251	54	cleavage	cleavage	NOUN
dti-1318	251	55	sites	site	NOUN
dti-1318	251	56	.	.	PUNCT
dti-1318	252	1	the	the	DET
dti-1318	252	2	lack	lack	NOUN
dti-1318	252	3	of	of	ADP
dti-1318	252	4	processing	processing	NOUN
dti-1318	252	5	of	of	ADP
dti-1318	252	6	any	any	PRON
dti-1318	252	7	of	of	ADP
dti-1318	252	8	these	these	DET
dti-1318	252	9	sites	site	NOUN
dti-1318	252	10	by	by	ADP
dti-1318	252	11	pr	pr	NOUN
dti-1318	252	12	results	result	NOUN
dti-1318	252	13	in	in	ADP
dti-1318	252	14	the	the	DET
dti-1318	252	15	formation	formation	NOUN
dti-1318	252	16	of	of	ADP
dti-1318	252	17	aberrant	aberrant	ADJ
dti-1318	252	18	particles	particle	NOUN
dti-1318	252	19	(	(	PUNCT
dti-1318	252	20	swanstrom	swanstrom	NOUN
dti-1318	252	21	,	,	PUNCT
dti-1318	252	22	1997	1997	NUM
dti-1318	252	23	)	)	PUNCT
dti-1318	252	24	.	.	PUNCT
dti-1318	253	1	in	in	ADP
dti-1318	253	2	particular	particular	ADJ
dti-1318	253	3	,	,	PUNCT
dti-1318	253	4	inhibition	inhibition	NOUN
dti-1318	253	5	of	of	ADP
dti-1318	253	6	cleavage	cleavage	NOUN
dti-1318	253	7	at	at	ADP
dti-1318	253	8	the	the	DET
dti-1318	253	9	ca	ca	NOUN
dti-1318	253	10	/	/	SYM
dti-1318	253	11	p2	p2	PROPN
dti-1318	253	12	site	site	NOUN
dti-1318	253	13	has	have	VERB
dti-1318	253	14	severe	severe	ADJ
dti-1318	253	15	consequences	consequence	NOUN
dti-1318	253	16	for	for	ADP
dti-1318	253	17	core	core	ADJ
dti-1318	253	18	formation	formation	NOUN
dti-1318	253	19	,	,	PUNCT
dti-1318	253	20	stability	stability	NOUN
dti-1318	253	21	and	and	CCONJ
dti-1318	253	22	virion	virion	NOUN
dti-1318	253	23	infectivity	infectivity	NOUN
dti-1318	253	24	(	(	PUNCT
dti-1318	253	25	pettit	pettit	PROPN
dti-1318	253	26	et	et	PROPN
dti-1318	253	27	al	al	PROPN
dti-1318	253	28	.	.	PROPN
dti-1318	253	29	1994	1994	NUM
dti-1318	253	30	;	;	PUNCT
dti-1318	253	31	wiegers	wieger	NOUN
dti-1318	253	32	et	et	PROPN
dti-1318	253	33	al	al	PROPN
dti-1318	253	34	.	.	PROPN
dti-1318	253	35	1998	1998	NUM
dti-1318	253	36	;	;	PUNCT
dti-1318	253	37	pettit	pettit	PROPN
dti-1318	253	38	et	et	PROPN
dti-1318	253	39	al	al	PROPN
dti-1318	253	40	.	.	PROPN
dti-1318	253	41	1998	1998	NUM
dti-1318	253	42	;	;	PUNCT
dti-1318	253	43	shehuxhilaga	shehuxhilaga	NOUN
dti-1318	253	44	et	et	PROPN
dti-1318	253	45	al	al	PROPN
dti-1318	253	46	.	.	PROPN
dti-1318	253	47	2001b	2001b	NUM
dti-1318	253	48	)	)	PUNCT
dti-1318	253	49	.	.	PUNCT
dti-1318	254	1	the	the	DET
dti-1318	254	2	α	α	NOUN
dti-1318	254	3	-	-	ADJ
dti-1318	254	4	helical	helical	ADJ
dti-1318	254	5	structure	structure	NOUN
dti-1318	254	6	that	that	PRON
dti-1318	254	7	stretches	stretch	VERB
dti-1318	254	8	between	between	ADP
dti-1318	254	9	the	the	DET
dti-1318	254	10	c	c	NOUN
dti-1318	254	11	-	-	PUNCT
dti-1318	254	12	terminus	terminus	NOUN
dti-1318	254	13	of	of	ADP
dti-1318	254	14	ca	ca	NOUN
dti-1318	254	15	and	and	CCONJ
dti-1318	254	16	the	the	DET
dti-1318	254	17	n	n	CCONJ
dti-1318	254	18	-	-	PUNCT
dti-1318	254	19	terminus	terminus	NOUN
dti-1318	254	20	of	of	ADP
dti-1318	254	21	sp1	sp1	NOUN
dti-1318	254	22	is	be	AUX
dti-1318	254	23	critical	critical	ADJ
dti-1318	254	24	for	for	ADP
dti-1318	254	25	virion	virion	NOUN
dti-1318	254	26	assembly	assembly	NOUN
dti-1318	254	27	and	and	CCONJ
dti-1318	254	28	p2	p2	PROPN
dti-1318	254	29	function	function	NOUN
dti-1318	254	30	(	(	PUNCT
dti-1318	254	31	accola	accola	PROPN
dti-1318	254	32	et	et	PROPN
dti-1318	254	33	al	al	PROPN
dti-1318	254	34	.	.	PROPN
dti-1318	254	35	1998	1998	NUM
dti-1318	254	36	)	)	PUNCT
dti-1318	254	37	.	.	PUNCT
dti-1318	255	1	clearly	clearly	ADV
dti-1318	255	2	,	,	PUNCT
dti-1318	255	3	these	these	DET
dti-1318	255	4	pr	pr	NOUN
dti-1318	255	5	cleavage	cleavage	NOUN
dti-1318	255	6	sites	site	NOUN
dti-1318	255	7	are	be	AUX
dti-1318	255	8	potential	potential	ADJ
dti-1318	255	9	targets	target	NOUN
dti-1318	255	10	for	for	ADP
dti-1318	255	11	antiretroviral	antiretroviral	ADJ
dti-1318	255	12	drug	drug	NOUN
dti-1318	255	13	design	design	NOUN
dti-1318	255	14	.	.	PUNCT
dti-1318	256	1	in	in	ADP
dti-1318	256	2	this	this	DET
dti-1318	256	3	regard	regard	NOUN
dti-1318	256	4	,	,	PUNCT
dti-1318	256	5	a	a	DET
dti-1318	256	6	compound	compound	NOUN
dti-1318	256	7	that	that	PRON
dti-1318	256	8	interferes	interfere	VERB
dti-1318	256	9	with	with	ADP
dti-1318	256	10	viral	viral	ADJ
dti-1318	256	11	maturation	maturation	NOUN
dti-1318	256	12	by	by	ADP
dti-1318	256	13	blocking	block	VERB
dti-1318	256	14	ca	ca	NOUN
dti-1318	256	15	/	/	SYM
dti-1318	256	16	p2	p2	PROPN
dti-1318	256	17	cleavage	cleavage	NOUN
dti-1318	256	18	has	have	AUX
dti-1318	256	19	been	be	AUX
dti-1318	256	20	identifi	identifi	PROPN
dti-1318	256	21	ed	ed	NOUN
dti-1318	256	22	.	.	PROPN
dti-1318	257	1	3	3	NUM
dti-1318	257	2	-	-	PUNCT
dti-1318	257	3	o-(3′,3′-dimethysuccinyl	o-(3′,3′-dimethysuccinyl	ADJ
dti-1318	257	4	)	)	PUNCT
dti-1318	257	5	betulinic	betulinic	ADJ
dti-1318	257	6	acid	acid	NOUN
dti-1318	257	7	(	(	PUNCT
dti-1318	257	8	pa-457	pa-457	PROPN
dti-1318	257	9	or	or	CCONJ
dti-1318	257	10	bevirimat	bevirimat	NOUN
dti-1318	257	11	)	)	PUNCT
dti-1318	257	12	potently	potently	ADV
dti-1318	257	13	inhibits	inhibit	VERB
dti-1318	257	14	hiv-1	hiv-1	ADJ
dti-1318	257	15	maturation	maturation	NOUN
dti-1318	257	16	and	and	CCONJ
dti-1318	257	17	infectivity	infectivity	NOUN
dti-1318	257	18	(	(	PUNCT
dti-1318	257	19	li	li	PROPN
dti-1318	257	20	et	et	PROPN
dti-1318	257	21	al	al	PROPN
dti-1318	257	22	.	.	PROPN
dti-1318	257	23	2003	2003	NUM
dti-1318	257	24	;	;	PUNCT
dti-1318	257	25	zhou	zhou	PROPN
dti-1318	257	26	et	et	PROPN
dti-1318	257	27	al	al	PROPN
dti-1318	257	28	.	.	PROPN
dti-1318	257	29	2004	2004	NUM
dti-1318	257	30	)	)	PUNCT
dti-1318	257	31	.	.	PUNCT
dti-1318	258	1	pa-457	pa-457	PROPN
dti-1318	258	2	specifi	specifi	PROPN
dti-1318	258	3	cally	cally	ADV
dti-1318	258	4	blocks	block	VERB
dti-1318	258	5	the	the	DET
dti-1318	258	6	cleavage	cleavage	NOUN
dti-1318	258	7	of	of	ADP
dti-1318	258	8	ca	ca	NOUN
dti-1318	258	9	/	/	SYM
dti-1318	258	10	p2	p2	PROPN
dti-1318	258	11	in	in	ADP
dti-1318	258	12	cell	cell	NOUN
dti-1318	258	13	based	base	VERB
dti-1318	258	14	(	(	PUNCT
dti-1318	258	15	li	li	PROPN
dti-1318	258	16	et	et	PROPN
dti-1318	258	17	al	al	PROPN
dti-1318	258	18	.	.	PROPN
dti-1318	258	19	2003	2003	NUM
dti-1318	258	20	)	)	PUNCT
dti-1318	258	21	and	and	CCONJ
dti-1318	258	22	in	in	ADP
dti-1318	258	23	cell	cell	NOUN
dti-1318	258	24	free	free	ADJ
dti-1318	258	25	assays	assay	NOUN
dti-1318	258	26	(	(	PUNCT
dti-1318	258	27	zhou	zhou	X
dti-1318	258	28	et	et	PROPN
dti-1318	258	29	al	al	PROPN
dti-1318	258	30	.	.	PROPN
dti-1318	258	31	2005	2005	NUM
dti-1318	258	32	;	;	PUNCT
dti-1318	258	33	sakalian	sakalian	NOUN
dti-1318	258	34	et	et	PROPN
dti-1318	258	35	al	al	PROPN
dti-1318	258	36	.	.	PROPN
dti-1318	258	37	2006	2006	NUM
dti-1318	258	38	)	)	PUNCT
dti-1318	258	39	,	,	PUNCT
dti-1318	258	40	thus	thus	ADV
dti-1318	258	41	inhibiting	inhibit	VERB
dti-1318	258	42	core	core	NOUN
dti-1318	258	43	condensation	condensation	NOUN
dti-1318	258	44	and	and	CCONJ
dti-1318	258	45	virion	virion	NOUN
dti-1318	258	46	maturation	maturation	NOUN
dti-1318	258	47	.	.	PUNCT
dti-1318	259	1	inhibition	inhibition	NOUN
dti-1318	259	2	of	of	ADP
dti-1318	259	3	gag	gag	NOUN
dti-1318	259	4	processing	processing	NOUN
dti-1318	259	5	at	at	ADP
dti-1318	259	6	the	the	DET
dti-1318	259	7	ca	ca	NOUN
dti-1318	259	8	/	/	SYM
dti-1318	259	9	p2	p2	PROPN
dti-1318	259	10	junction	junction	NOUN
dti-1318	259	11	results	result	NOUN
dti-1318	259	12	in	in	ADP
dti-1318	259	13	the	the	DET
dti-1318	259	14	generation	generation	NOUN
dti-1318	259	15	of	of	ADP
dti-1318	259	16	the	the	DET
dti-1318	259	17	uncleaved	uncleave	VERB
dti-1318	259	18	p25	p25	NOUN
dti-1318	259	19	product	product	NOUN
dti-1318	259	20	in	in	ADP
dti-1318	259	21	transfected	transfecte	VERB
dti-1318	259	22	cells	cell	NOUN
dti-1318	259	23	at	at	ADP
dti-1318	259	24	0.1	0.1	NUM
dti-1318	259	25	µg	µg	NOUN
dti-1318	259	26	/	/	SYM
dti-1318	259	27	ml	ml	NOUN
dti-1318	259	28	of	of	ADP
dti-1318	259	29	pa-457	pa-457	PROPN
dti-1318	259	30	(	(	PUNCT
dti-1318	259	31	li	li	PROPN
dti-1318	259	32	et	et	PROPN
dti-1318	259	33	al	al	PROPN
dti-1318	259	34	.	.	PROPN
dti-1318	259	35	2003	2003	NUM
dti-1318	259	36	)	)	PUNCT
dti-1318	259	37	.	.	PUNCT
dti-1318	260	1	consistent	consistent	ADJ
dti-1318	260	2	with	with	ADP
dti-1318	260	3	the	the	DET
dti-1318	260	4	proposed	propose	VERB
dti-1318	260	5	mechanism	mechanism	NOUN
dti-1318	260	6	,	,	PUNCT
dti-1318	260	7	pa-457	pa-457	PROPN
dti-1318	260	8	resistant	resistant	ADJ
dti-1318	260	9	hiv-1	hiv-1	PUNCT
dti-1318	260	10	selected	select	VERB
dti-1318	260	11	in	in	ADP
dti-1318	260	12	long	long	ADJ
dti-1318	260	13	term	term	NOUN
dti-1318	260	14	cultures	culture	NOUN
dti-1318	260	15	in	in	ADP
dti-1318	260	16	the	the	DET
dti-1318	260	17	presence	presence	NOUN
dti-1318	260	18	of	of	ADP
dti-1318	260	19	betulinic	betulinic	ADJ
dti-1318	260	20	acid	acid	NOUN
dti-1318	260	21	contain	contain	NOUN
dti-1318	260	22	mutations	mutation	NOUN
dti-1318	260	23	in	in	ADP
dti-1318	260	24	the	the	DET
dti-1318	260	25	regions	region	NOUN
dti-1318	260	26	that	that	PRON
dti-1318	260	27	fl	fl	PROPN
dti-1318	260	28	ank	ank	PROPN
dti-1318	260	29	the	the	DET
dti-1318	260	30	p	p	PROPN
dti-1318	260	31	-	-	PUNCT
dti-1318	260	32	p	p	NOUN
dti-1318	260	33	’	'	PUNCT
dti-1318	260	34	scissile	scissile	NOUN
dti-1318	260	35	bond	bond	NOUN
dti-1318	260	36	(	(	PUNCT
dti-1318	260	37	adamson	adamson	PROPN
dti-1318	260	38	et	et	PROPN
dti-1318	260	39	al	al	PROPN
dti-1318	260	40	.	.	PROPN
dti-1318	260	41	2006	2006	NUM
dti-1318	260	42	;	;	PUNCT
dti-1318	260	43	zhou	zhou	PROPN
dti-1318	260	44	et	et	PROPN
dti-1318	260	45	al	al	PROPN
dti-1318	260	46	.	.	PROPN
dti-1318	260	47	2006	2006	NUM
dti-1318	260	48	)	)	PUNCT
dti-1318	260	49	.	.	PUNCT
dti-1318	261	1	these	these	DET
dti-1318	261	2	mutated	mutate	VERB
dti-1318	261	3	sites	site	NOUN
dti-1318	261	4	in	in	ADP
dti-1318	261	5	gag	gag	NOUN
dti-1318	261	6	are	be	AUX
dti-1318	261	7	recognized	recognize	VERB
dti-1318	261	8	by	by	ADP
dti-1318	261	9	the	the	DET
dti-1318	261	10	viral	viral	ADJ
dti-1318	261	11	pr	pr	NOUN
dti-1318	261	12	during	during	ADP
dti-1318	261	13	proteolysis	proteolysis	NOUN
dti-1318	261	14	.	.	PUNCT
dti-1318	262	1	in	in	ADP
dti-1318	262	2	addition	addition	NOUN
dti-1318	262	3	,	,	PUNCT
dti-1318	262	4	other	other	ADJ
dti-1318	262	5	single	single	ADJ
dti-1318	262	6	amino	amino	NOUN
dti-1318	262	7	acid	acid	NOUN
dti-1318	262	8	substitutions	substitution	NOUN
dti-1318	262	9	have	have	AUX
dti-1318	262	10	been	be	AUX
dti-1318	262	11	identifi	identifi	PROPN
dti-1318	262	12	ed	ed	NOUN
dti-1318	262	13	that	that	PRON
dti-1318	262	14	confer	confer	VERB
dti-1318	262	15	resistance	resistance	NOUN
dti-1318	262	16	to	to	ADP
dti-1318	262	17	pa-457	pa-457	PROPN
dti-1318	262	18	and	and	CCONJ
dti-1318	262	19	are	be	AUX
dti-1318	262	20	exclusively	exclusively	ADV
dti-1318	262	21	located	locate	VERB
dti-1318	262	22	either	either	CCONJ
dti-1318	262	23	at	at	ADP
dti-1318	262	24	the	the	DET
dti-1318	262	25	c	c	PROPN
dti-1318	262	26	terminus	terminus	NOUN
dti-1318	262	27	of	of	ADP
dti-1318	262	28	ca	ca	NOUN
dti-1318	262	29	or	or	CCONJ
dti-1318	262	30	within	within	ADP
dti-1318	262	31	the	the	DET
dti-1318	262	32	fi	fi	NOUN
dti-1318	262	33	rst	rst	PROPN
dti-1318	262	34	three	three	NUM
dti-1318	262	35	amino	amino	ADJ
dti-1318	262	36	acids	acid	NOUN
dti-1318	262	37	of	of	ADP
dti-1318	262	38	the	the	DET
dti-1318	262	39	p2	p2	PROPN
dti-1318	262	40	spacer	spacer	NOUN
dti-1318	262	41	peptide	peptide	NOUN
dti-1318	262	42	(	(	PUNCT
dti-1318	262	43	adamson	adamson	PROPN
dti-1318	262	44	et	et	PROPN
dti-1318	262	45	al	al	PROPN
dti-1318	262	46	.	.	PROPN
dti-1318	262	47	2006	2006	NUM
dti-1318	262	48	)	)	PUNCT
dti-1318	262	49	.	.	PUNCT
dti-1318	263	1	interestingly	interestingly	ADV
dti-1318	263	2	,	,	PUNCT
dti-1318	263	3	they	they	PRON
dti-1318	263	4	all	all	PRON
dti-1318	263	5	conferred	confer	VERB
dti-1318	263	6	resistance	resistance	NOUN
dti-1318	263	7	independently	independently	ADV
dti-1318	263	8	and	and	CCONJ
dti-1318	263	9	were	be	AUX
dti-1318	263	10	located	locate	VERB
dti-1318	263	11	within	within	ADP
dti-1318	263	12	the	the	DET
dti-1318	263	13	boundaries	boundary	NOUN
dti-1318	263	14	of	of	ADP
dti-1318	263	15	the	the	DET
dti-1318	263	16	ca	ca	NOUN
dti-1318	263	17	/	/	SYM
dti-1318	263	18	p2	p2	PROPN
dti-1318	263	19	proteins	protein	NOUN
dti-1318	263	20	,	,	PUNCT
dti-1318	263	21	a	a	DET
dti-1318	263	22	region	region	NOUN
dti-1318	263	23	well	well	ADV
dti-1318	263	24	known	know	VERB
dti-1318	263	25	to	to	PART
dti-1318	263	26	promote	promote	VERB
dti-1318	263	27	gag	gag	NOUN
dti-1318	263	28	multimerization	multimerization	NOUN
dti-1318	263	29	(	(	PUNCT
dti-1318	263	30	adamson	adamson	PROPN
dti-1318	263	31	et	et	PROPN
dti-1318	263	32	al	al	PROPN
dti-1318	263	33	.	.	PROPN
dti-1318	263	34	2006	2006	NUM
dti-1318	263	35	)	)	PUNCT
dti-1318	263	36	.	.	PUNCT
dti-1318	264	1	these	these	DET
dti-1318	264	2	data	datum	NOUN
dti-1318	264	3	suggest	suggest	VERB
dti-1318	264	4	that	that	SCONJ
dti-1318	264	5	there	there	PRON
dti-1318	264	6	is	be	VERB
dti-1318	264	7	more	more	ADJ
dti-1318	264	8	than	than	ADP
dti-1318	264	9	one	one	NUM
dti-1318	264	10	mechanism	mechanism	NOUN
dti-1318	264	11	by	by	ADP
dti-1318	264	12	which	which	PRON
dti-1318	264	13	these	these	DET
dti-1318	264	14	mutants	mutant	NOUN
dti-1318	264	15	have	have	AUX
dti-1318	264	16	acquired	acquire	VERB
dti-1318	264	17	resistance	resistance	NOUN
dti-1318	264	18	to	to	ADP
dti-1318	264	19	pa-457	pa-457	PROPN
dti-1318	264	20	.	.	PUNCT
dti-1318	265	1	pa-457	pa-457	PROPN
dti-1318	265	2	has	have	AUX
dti-1318	265	3	successfully	successfully	ADV
dti-1318	265	4	undergone	undergo	VERB
dti-1318	265	5	phase	phase	NOUN
dti-1318	265	6	1	1	NUM
dti-1318	265	7	and	and	CCONJ
dti-1318	265	8	2	2	NUM
dti-1318	265	9	clinical	clinical	ADJ
dti-1318	265	10	trials	trial	NOUN
dti-1318	265	11	and	and	CCONJ
dti-1318	265	12	is	be	AUX
dti-1318	265	13	currently	currently	ADV
dti-1318	265	14	in	in	ADP
dti-1318	265	15	a	a	DET
dti-1318	265	16	phase	phase	NOUN
dti-1318	265	17	2b	2b	NUM
dti-1318	265	18	trial	trial	NOUN
dti-1318	265	19	to	to	PART
dti-1318	265	20	test	test	VERB
dti-1318	265	21	the	the	DET
dti-1318	265	22	effi	effi	PROPN
dti-1318	265	23	cacy	cacy	NOUN
dti-1318	265	24	of	of	ADP
dti-1318	265	25	different	different	ADJ
dti-1318	265	26	doses	dose	NOUN
dti-1318	265	27	of	of	ADP
dti-1318	265	28	pa-457	pa-457	PROPN
dti-1318	265	29	in	in	ADP
dti-1318	265	30	combination	combination	NOUN
dti-1318	265	31	with	with	ADP
dti-1318	265	32	approved	approve	VERB
dti-1318	265	33	hiv-1	hiv-1	X
dti-1318	265	34	inhibitors	inhibitor	NOUN
dti-1318	265	35	as	as	ADP
dti-1318	265	36	part	part	NOUN
dti-1318	265	37	of	of	ADP
dti-1318	265	38	an	an	DET
dti-1318	265	39	optimised	optimise	VERB
dti-1318	265	40	regimen	regimen	NOUN
dti-1318	265	41	in	in	ADP
dti-1318	265	42	patients	patient	NOUN
dti-1318	265	43	failing	fail	VERB
dti-1318	265	44	therapy	therapy	NOUN
dti-1318	265	45	due	due	ADP
dti-1318	265	46	to	to	ADP
dti-1318	265	47	the	the	DET
dti-1318	265	48	emergence	emergence	NOUN
dti-1318	265	49	of	of	ADP
dti-1318	265	50	drug	drug	NOUN
dti-1318	265	51	resistant	resistant	ADJ
dti-1318	265	52	virus	virus	NOUN
dti-1318	265	53	.	.	PUNCT
dti-1318	266	1	targeting	target	VERB
dti-1318	266	2	the	the	DET
dti-1318	266	3	rt	rt	PROPN
dti-1318	266	4	domain	domain	NOUN
dti-1318	266	5	in	in	ADP
dti-1318	266	6	gag	gag	NOUN
dti-1318	266	7	-	-	PUNCT
dti-1318	266	8	pol	pol	NOUN
dti-1318	266	9	like	like	ADP
dti-1318	266	10	other	other	ADJ
dti-1318	266	11	hiv-1	hiv-1	X
dti-1318	266	12	enzymes	enzyme	NOUN
dti-1318	266	13	,	,	PUNCT
dti-1318	266	14	rt	rt	PROPN
dti-1318	266	15	subunits	subunit	NOUN
dti-1318	266	16	must	must	AUX
dti-1318	266	17	oligomerize	oligomerize	VERB
dti-1318	266	18	to	to	PART
dti-1318	266	19	form	form	VERB
dti-1318	266	20	an	an	DET
dti-1318	266	21	active	active	ADJ
dti-1318	266	22	enzyme	enzyme	NOUN
dti-1318	266	23	.	.	PUNCT
dti-1318	267	1	the	the	DET
dti-1318	267	2	biologically	biologically	ADV
dti-1318	267	3	relevant	relevant	ADJ
dti-1318	267	4	form	form	NOUN
dti-1318	267	5	that	that	PRON
dti-1318	267	6	is	be	AUX
dti-1318	267	7	present	present	ADJ
dti-1318	267	8	in	in	ADP
dti-1318	267	9	the	the	DET
dti-1318	267	10	virion	virion	NOUN
dti-1318	267	11	is	be	AUX
dti-1318	267	12	an	an	DET
dti-1318	267	13	asymmetric	asymmetric	ADJ
dti-1318	267	14	heterodimer	heterodimer	NOUN
dti-1318	267	15	comprised	comprise	VERB
dti-1318	267	16	of	of	ADP
dti-1318	267	17	the	the	DET
dti-1318	267	18	p66	p66	NOUN
dti-1318	267	19	(	(	PUNCT
dti-1318	267	20	66	66	NUM
dti-1318	267	21	kda	kda	NOUN
dti-1318	267	22	)	)	PUNCT
dti-1318	267	23	and	and	CCONJ
dti-1318	267	24	the	the	DET
dti-1318	267	25	p51	p51	PROPN
dti-1318	267	26	(	(	PUNCT
dti-1318	267	27	51	51	NUM
dti-1318	267	28	kda	kda	NOUN
dti-1318	267	29	)	)	PUNCT
dti-1318	267	30	subunits	subunit	NOUN
dti-1318	267	31	(	(	PUNCT
dti-1318	267	32	jacobo	jacobo	PROPN
dti-1318	267	33	-	-	PUNCT
dti-1318	267	34	molina	molina	PROPN
dti-1318	267	35	et	et	PROPN
dti-1318	267	36	al	al	PROPN
dti-1318	267	37	.	.	PROPN
dti-1318	267	38	1993	1993	NUM
dti-1318	267	39	;	;	PUNCT
dti-1318	267	40	kohlstaedt	kohlstaedt	PROPN
dti-1318	267	41	et	et	PROPN
dti-1318	267	42	al	al	PROPN
dti-1318	267	43	.	.	PROPN
dti-1318	267	44	1992	1992	NUM
dti-1318	267	45	)	)	PUNCT
dti-1318	267	46	.	.	PUNCT
dti-1318	268	1	the	the	DET
dti-1318	268	2	rt	rt	PROPN
dti-1318	268	3	heterodimer	heterodimer	NOUN
dti-1318	268	4	is	be	AUX
dti-1318	268	5	extremely	extremely	ADV
dti-1318	268	6	stable	stable	ADJ
dti-1318	268	7	and	and	CCONJ
dti-1318	268	8	has	have	VERB
dti-1318	268	9	an	an	DET
dti-1318	268	10	extensive	extensive	ADJ
dti-1318	268	11	protein	protein	NOUN
dti-1318	268	12	surface	surface	NOUN
dti-1318	268	13	area	area	NOUN
dti-1318	268	14	(	(	PUNCT
dti-1318	268	15	4800	4800	NUM
dti-1318	268	16	å2	å2	PROPN
dti-1318	268	17	)	)	PUNCT
dti-1318	268	18	that	that	PRON
dti-1318	268	19	is	be	AUX
dti-1318	268	20	buried	bury	VERB
dti-1318	268	21	upon	upon	SCONJ
dti-1318	268	22	subunit	subunit	NOUN
dti-1318	268	23	dimerization	dimerization	NOUN
dti-1318	268	24	.	.	PUNCT
dti-1318	269	1	thermodynamic	thermodynamic	ADJ
dti-1318	269	2	measurements	measurement	NOUN
dti-1318	269	3	of	of	ADP
dti-1318	269	4	the	the	DET
dti-1318	269	5	association	association	NOUN
dti-1318	269	6	between	between	ADP
dti-1318	269	7	the	the	DET
dti-1318	269	8	p66	p66	NOUN
dti-1318	269	9	and	and	CCONJ
dti-1318	269	10	p51	p51	PROPN
dti-1318	269	11	rt	rt	PROPN
dti-1318	269	12	subunits	subunit	NOUN
dti-1318	269	13	have	have	AUX
dti-1318	269	14	estimated	estimate	VERB
dti-1318	269	15	gibbs	gibbs	PROPN
dti-1318	269	16	free	free	ADJ
dti-1318	269	17	energy	energy	NOUN
dti-1318	269	18	of	of	ADP
dti-1318	269	19	dimer	dimer	ADJ
dti-1318	269	20	stabilization	stabilization	NOUN
dti-1318	269	21	of	of	ADP
dti-1318	269	22	approximately	approximately	ADV
dti-1318	269	23	10–12	10–12	NUM
dti-1318	269	24	kcal	kcal	NOUN
dti-1318	269	25	/	/	SYM
dti-1318	269	26	mol–1	mol–1	NOUN
dti-1318	269	27	,	,	PUNCT
dti-1318	269	28	corresponding	correspond	VERB
dti-1318	269	29	to	to	ADP
dti-1318	269	30	a	a	DET
dti-1318	269	31	dissociation	dissociation	NOUN
dti-1318	269	32	constant	constant	ADJ
dti-1318	269	33	of	of	ADP
dti-1318	269	34	approximately	approximately	ADV
dti-1318	269	35	3	3	NUM
dti-1318	269	36	×	×	NOUN
dti-1318	269	37	10–7	10–7	NUM
dti-1318	269	38	m	m	NOUN
dti-1318	269	39	(	(	PUNCT
dti-1318	269	40	venezia	venezia	PROPN
dti-1318	269	41	et	et	PROPN
dti-1318	269	42	al	al	PROPN
dti-1318	269	43	.	.	PROPN
dti-1318	269	44	2006	2006	NUM
dti-1318	269	45	)	)	PUNCT
dti-1318	269	46	.	.	PUNCT
dti-1318	270	1	for	for	ADP
dti-1318	270	2	an	an	DET
dti-1318	270	3	extensive	extensive	ADJ
dti-1318	270	4	review	review	NOUN
dti-1318	270	5	on	on	ADP
dti-1318	270	6	hiv-1	hiv-1	X
dti-1318	270	7	rt	rt	PROPN
dti-1318	270	8	dimerization	dimerization	NOUN
dti-1318	270	9	see	see	VERB
dti-1318	270	10	srivastava	srivastava	PROPN
dti-1318	270	11	et	et	PROPN
dti-1318	270	12	al	al	PROPN
dti-1318	270	13	.	.	PROPN
dti-1318	270	14	2006	2006	NUM
dti-1318	270	15	.	.	PUNCT
dti-1318	271	1	regions	region	NOUN
dti-1318	271	2	both	both	CCONJ
dti-1318	271	3	upstream	upstream	ADJ
dti-1318	271	4	and	and	CCONJ
dti-1318	271	5	downstream	downstream	ADJ
dti-1318	271	6	of	of	ADP
dti-1318	271	7	the	the	DET
dti-1318	271	8	pr	pr	NOUN
dti-1318	271	9	region	region	NOUN
dti-1318	271	10	in	in	ADP
dti-1318	271	11	gag	gag	NOUN
dti-1318	271	12	-	-	PUNCT
dti-1318	271	13	pol	pol	NOUN
dti-1318	271	14	have	have	AUX
dti-1318	271	15	been	be	AUX
dti-1318	271	16	investigated	investigate	VERB
dti-1318	271	17	for	for	ADP
dti-1318	271	18	effects	effect	NOUN
dti-1318	271	19	on	on	ADP
dti-1318	271	20	pr	pr	NOUN
dti-1318	271	21	activation	activation	NOUN
dti-1318	271	22	(	(	PUNCT
dti-1318	271	23	bukovsky	bukovsky	NOUN
dti-1318	271	24	and	and	CCONJ
dti-1318	271	25	gottlinger	gottlinger	NOUN
dti-1318	271	26	,	,	PUNCT
dti-1318	271	27	1996	1996	NUM
dti-1318	271	28	;	;	PUNCT
dti-1318	271	29	partin	partin	PROPN
dti-1318	271	30	et	et	PROPN
dti-1318	271	31	al	al	PROPN
dti-1318	271	32	.	.	PROPN
dti-1318	271	33	1991	1991	NUM
dti-1318	271	34	;	;	PUNCT
dti-1318	271	35	louis	louis	PROPN
dti-1318	271	36	et	et	PROPN
dti-1318	271	37	al	al	PROPN
dti-1318	271	38	.	.	PROPN
dti-1318	271	39	1999	1999	NUM
dti-1318	271	40	)	)	PUNCT
dti-1318	271	41	.	.	PUNCT
dti-1318	272	1	large	large	ADJ
dti-1318	272	2	deletions	deletion	NOUN
dti-1318	272	3	within	within	ADP
dti-1318	272	4	or	or	CCONJ
dti-1318	272	5	c	c	NOUN
dti-1318	272	6	-	-	PUNCT
dti-1318	272	7	terminal	terminal	ADJ
dti-1318	272	8	truncations	truncation	NOUN
dti-1318	272	9	of	of	ADP
dti-1318	272	10	rt	rt	PROPN
dti-1318	272	11	in	in	ADP
dti-1318	272	12	the	the	DET
dti-1318	272	13	context	context	NOUN
dti-1318	272	14	of	of	ADP
dti-1318	272	15	gag	gag	NOUN
dti-1318	272	16	-	-	PUNCT
dti-1318	272	17	pol	pol	NOUN
dti-1318	272	18	result	result	NOUN
dti-1318	272	19	in	in	ADP
dti-1318	272	20	an	an	DET
dti-1318	272	21	increase	increase	NOUN
dti-1318	272	22	in	in	ADP
dti-1318	272	23	virion	virion	NOUN
dti-1318	272	24	associated	associate	VERB
dti-1318	272	25	gag	gag	NOUN
dti-1318	272	26	processing	processing	NOUN
dti-1318	272	27	intermediates	intermediate	NOUN
dti-1318	272	28	,	,	PUNCT
dti-1318	272	29	suggesting	suggest	VERB
dti-1318	272	30	a	a	DET
dti-1318	272	31	defect	defect	NOUN
dti-1318	272	32	in	in	ADP
dti-1318	272	33	pr	pr	NOUN
dti-1318	272	34	activity	activity	NOUN
dti-1318	272	35	(	(	PUNCT
dti-1318	272	36	cherry	cherry	NOUN
dti-1318	272	37	et	et	PROPN
dti-1318	272	38	al	al	PROPN
dti-1318	272	39	.	.	PROPN
dti-1318	272	40	1998	1998	NUM
dti-1318	272	41	;	;	PUNCT
dti-1318	272	42	liao	liao	PROPN
dti-1318	272	43	and	and	CCONJ
dti-1318	272	44	wang	wang	PROPN
dti-1318	272	45	,	,	PUNCT
dti-1318	272	46	2004	2004	NUM
dti-1318	272	47	;	;	PUNCT
dti-1318	272	48	quillent	quillent	NOUN
dti-1318	272	49	et	et	PROPN
dti-1318	272	50	al	al	PROPN
dti-1318	272	51	.	.	PROPN
dti-1318	272	52	1996	1996	NUM
dti-1318	272	53	)	)	PUNCT
dti-1318	272	54	.	.	PUNCT
dti-1318	273	1	these	these	DET
dti-1318	273	2	studies	study	NOUN
dti-1318	273	3	suggest	suggest	VERB
dti-1318	273	4	that	that	SCONJ
dti-1318	273	5	modulating	modulate	VERB
dti-1318	273	6	rt	rt	NOUN
dti-1318	273	7	dimerization	dimerization	NOUN
dti-1318	273	8	in	in	ADP
dti-1318	273	9	the	the	DET
dti-1318	273	10	context	context	NOUN
dti-1318	273	11	of	of	ADP
dti-1318	273	12	gag	gag	NOUN
dti-1318	273	13	-	-	PUNCT
dti-1318	273	14	pol	pol	NOUN
dti-1318	273	15	may	may	AUX
dti-1318	273	16	have	have	VERB
dti-1318	273	17	a	a	DET
dti-1318	273	18	negative	negative	ADJ
dti-1318	273	19	impact	impact	NOUN
dti-1318	273	20	on	on	ADP
dti-1318	273	21	pr	pr	NOUN
dti-1318	273	22	activation	activation	NOUN
dti-1318	273	23	and	and	CCONJ
dti-1318	273	24	hiv-1	hiv-1	X
dti-1318	273	25	maturation	maturation	NOUN
dti-1318	273	26	.	.	PUNCT
dti-1318	274	1	the	the	DET
dti-1318	274	2	importance	importance	NOUN
dti-1318	274	3	of	of	ADP
dti-1318	274	4	the	the	DET
dti-1318	274	5	rt	rt	PROPN
dti-1318	274	6	region	region	NOUN
dti-1318	274	7	in	in	ADP
dti-1318	274	8	gag	gag	NOUN
dti-1318	274	9	-	-	PUNCT
dti-1318	274	10	pol	pol	NOUN
dti-1318	274	11	for	for	ADP
dti-1318	274	12	both	both	PRON
dti-1318	274	13	rt	rt	NOUN
dti-1318	274	14	maturation	maturation	NOUN
dti-1318	274	15	and	and	CCONJ
dti-1318	274	16	viral	viral	ADJ
dti-1318	274	17	particle	particle	NOUN
dti-1318	274	18	production	production	NOUN
dti-1318	274	19	has	have	AUX
dti-1318	274	20	been	be	AUX
dti-1318	274	21	demonstrated	demonstrate	VERB
dti-1318	274	22	by	by	ADP
dti-1318	274	23	the	the	DET
dti-1318	274	24	study	study	NOUN
dti-1318	274	25	of	of	ADP
dti-1318	274	26	rt	rt	PROPN
dti-1318	274	27	point	point	NOUN
dti-1318	274	28	mutations	mutation	NOUN
dti-1318	274	29	that	that	PRON
dti-1318	274	30	prevent	prevent	VERB
dti-1318	274	31	rt	rt	PROPN
dti-1318	274	32	heterodimerization	heterodimerization	NOUN
dti-1318	274	33	and	and	CCONJ
dti-1318	274	34	p66	p66	NOUN
dti-1318	274	35	homodimerization	homodimerization	NOUN
dti-1318	274	36	.	.	PUNCT
dti-1318	275	1	mutations	mutation	NOUN
dti-1318	275	2	at	at	ADP
dti-1318	275	3	w401	w401	PROPN
dti-1318	275	4	,	,	PUNCT
dti-1318	275	5	a	a	DET
dti-1318	275	6	component	component	NOUN
dti-1318	275	7	of	of	ADP
dti-1318	275	8	the	the	DET
dti-1318	275	9	highly	highly	ADV
dti-1318	275	10	conserved	conserved	ADJ
dti-1318	275	11	tryptophan	tryptophan	NOUN
dti-1318	275	12	repeat	repeat	NOUN
dti-1318	275	13	motif	motif	NOUN
dti-1318	275	14	in	in	ADP
dti-1318	275	15	the	the	DET
dti-1318	275	16	connection	connection	NOUN
dti-1318	275	17	subdomain	subdomain	NOUN
dti-1318	275	18	,	,	PUNCT
dti-1318	275	19	blocks	block	VERB
dti-1318	275	20	rt	rt	NOUN
dti-1318	275	21	dimerization	dimerization	NOUN
dti-1318	275	22	in	in	ADP
dti-1318	275	23	vitro	vitro	X
dti-1318	275	24	(	(	PUNCT
dti-1318	275	25	tachedjian	tachedjian	NOUN
dti-1318	275	26	et	et	PROPN
dti-1318	275	27	al	al	PROPN
dti-1318	275	28	.	.	PROPN
dti-1318	275	29	2003	2003	NUM
dti-1318	275	30	;	;	PUNCT
dti-1318	275	31	tachedjian	tachedjian	NOUN
dti-1318	275	32	et	et	PROPN
dti-1318	275	33	al	al	PROPN
dti-1318	275	34	.	.	PROPN
dti-1318	275	35	2005b	2005b	NUM
dti-1318	275	36	)	)	PUNCT
dti-1318	275	37	.	.	PUNCT
dti-1318	276	1	when	when	SCONJ
dti-1318	276	2	expressed	express	VERB
dti-1318	276	3	in	in	ADP
dti-1318	276	4	hiv-1	hiv-1	X
dti-1318	276	5	it	it	PRON
dti-1318	276	6	manifests	manifest	VERB
dti-1318	276	7	as	as	ADP
dti-1318	276	8	defects	defect	NOUN
dti-1318	276	9	in	in	ADP
dti-1318	276	10	reverse	reverse	ADJ
dti-1318	276	11	transcription	transcription	NOUN
dti-1318	276	12	,	,	PUNCT
dti-1318	276	13	aberrant	aberrant	ADJ
dti-1318	276	14	processing	processing	NOUN
dti-1318	276	15	of	of	ADP
dti-1318	276	16	rt	rt	PROPN
dti-1318	276	17	,	,	PUNCT
dti-1318	276	18	and	and	CCONJ
dti-1318	276	19	low	low	ADJ
dti-1318	276	20	levels	level	NOUN
dti-1318	276	21	of	of	ADP
dti-1318	276	22	infectivity	infectivity	NOUN
dti-1318	276	23	(	(	PUNCT
dti-1318	276	24	wapling	waple	VERB
dti-1318	276	25	et	et	PROPN
dti-1318	276	26	al	al	PROPN
dti-1318	276	27	.	.	PROPN
dti-1318	276	28	2005	2005	NUM
dti-1318	276	29	)	)	PUNCT
dti-1318	276	30	.	.	PUNCT
dti-1318	277	1	the	the	DET
dti-1318	277	2	l234a	l234a	PROPN
dti-1318	277	3	mutation	mutation	NOUN
dti-1318	277	4	,	,	PUNCT
dti-1318	277	5	located	locate	VERB
dti-1318	277	6	in	in	ADP
dti-1318	277	7	the	the	DET
dti-1318	277	8	rt	rt	PROPN
dti-1318	277	9	primer	primer	PROPN
dti-1318	277	10	grip	grip	PROPN
dti-1318	277	11	region	region	NOUN
dti-1318	277	12	,	,	PUNCT
dti-1318	277	13	prevents	prevent	VERB
dti-1318	277	14	rt	rt	NOUN
dti-1318	277	15	dimerization	dimerization	NOUN
dti-1318	277	16	and	and	CCONJ
dti-1318	277	17	decreases	decrease	VERB
dti-1318	277	18	gag	gag	NOUN
dti-1318	277	19	-	-	PUNCT
dti-1318	277	20	pol	pol	NOUN
dti-1318	277	21	stability	stability	NOUN
dti-1318	277	22	(	(	PUNCT
dti-1318	277	23	tachedjian	tachedjian	NOUN
dti-1318	277	24	et	et	PROPN
dti-1318	277	25	al	al	PROPN
dti-1318	277	26	.	.	PROPN
dti-1318	277	27	2000	2000	NUM
dti-1318	277	28	;	;	PUNCT
dti-1318	277	29	yu	yu	PROPN
dti-1318	277	30	et	et	PROPN
dti-1318	277	31	al	al	PROPN
dti-1318	277	32	.	.	PROPN
dti-1318	277	33	1998	1998	NUM
dti-1318	277	34	)	)	PUNCT
dti-1318	277	35	.	.	PUNCT
dti-1318	278	1	this	this	DET
dti-1318	278	2	mutation	mutation	NOUN
dti-1318	278	3	reduces	reduce	VERB
dti-1318	278	4	pr	pr	NOUN
dti-1318	278	5	incorporation	incorporation	NOUN
dti-1318	278	6	into	into	ADP
dti-1318	278	7	virions	virion	NOUN
dti-1318	278	8	,	,	PUNCT
dti-1318	278	9	increases	increase	VERB
dti-1318	278	10	the	the	DET
dti-1318	278	11	accumulation	accumulation	NOUN
dti-1318	278	12	of	of	ADP
dti-1318	278	13	gag	gag	NOUN
dti-1318	278	14	processing	processing	NOUN
dti-1318	278	15	intermediates	intermediate	NOUN
dti-1318	278	16	,	,	PUNCT
dti-1318	278	17	and	and	CCONJ
dti-1318	278	18	results	result	NOUN
dti-1318	278	19	in	in	ADP
dti-1318	278	20	the	the	DET
dti-1318	278	21	production	production	NOUN
dti-1318	278	22	of	of	ADP
dti-1318	278	23	non	non	ADJ
dti-1318	278	24	-	-	ADJ
dti-1318	278	25	infectious	infectious	ADJ
dti-1318	278	26	virus	virus	NOUN
dti-1318	278	27	particles	particle	NOUN
dti-1318	278	28	(	(	PUNCT
dti-1318	278	29	tachedjian	tachedjian	NOUN
dti-1318	278	30	et	et	PROPN
dti-1318	278	31	al	al	PROPN
dti-1318	278	32	.	.	PROPN
dti-1318	278	33	2000	2000	NUM
dti-1318	278	34	;	;	PUNCT
dti-1318	278	35	yu	yu	PROPN
dti-1318	278	36	et	et	PROPN
dti-1318	278	37	al	al	PROPN
dti-1318	278	38	.	.	PROPN
dti-1318	278	39	1998	1998	NUM
dti-1318	278	40	)	)	PUNCT
dti-1318	278	41	.	.	PUNCT
dti-1318	279	1	these	these	DET
dti-1318	279	2	examples	example	NOUN
dti-1318	279	3	demonstrate	demonstrate	VERB
dti-1318	279	4	the	the	DET
dti-1318	279	5	potential	potential	NOUN
dti-1318	279	6	for	for	ADP
dti-1318	279	7	171	171	NUM
dti-1318	279	8	targeting	target	VERB
dti-1318	279	9	the	the	DET
dti-1318	279	10	late	late	ADJ
dti-1318	279	11	stages	stage	NOUN
dti-1318	279	12	of	of	ADP
dti-1318	279	13	hiv-1	hiv-1	X
dti-1318	279	14	replication	replication	NOUN
dti-1318	279	15	drug	drug	NOUN
dti-1318	279	16	target	target	NOUN
dti-1318	279	17	insights	insight	NOUN
dti-1318	279	18	2007	2007	NUM
dti-1318	279	19	:	:	PUNCT
dti-1318	279	20	2	2	NUM
dti-1318	279	21	targeting	target	VERB
dti-1318	279	22	the	the	DET
dti-1318	279	23	gag	gag	NOUN
dti-1318	279	24	-	-	PUNCT
dti-1318	279	25	pol	pol	NOUN
dti-1318	279	26	embedded	embed	VERB
dti-1318	279	27	rt	rt	PROPN
dti-1318	279	28	for	for	ADP
dti-1318	279	29	blocking	block	VERB
dti-1318	279	30	hiv-1	hiv-1	X
dti-1318	279	31	maturation	maturation	NOUN
dti-1318	279	32	.	.	PUNCT
dti-1318	280	1	inhibitors	inhibitor	NOUN
dti-1318	280	2	that	that	PRON
dti-1318	280	3	modulate	modulate	VERB
dti-1318	280	4	hiv-1	hiv-1	PUNCT
dti-1318	280	5	rt	rt	PROPN
dti-1318	280	6	subunit	subunit	NOUN
dti-1318	280	7	interaction	interaction	NOUN
dti-1318	280	8	apart	apart	ADV
dti-1318	280	9	from	from	ADP
dti-1318	280	10	classical	classical	ADJ
dti-1318	280	11	nnrtis	nnrtis	NOUN
dti-1318	280	12	,	,	PUNCT
dti-1318	280	13	there	there	PRON
dti-1318	280	14	exists	exist	VERB
dti-1318	280	15	a	a	DET
dti-1318	280	16	class	class	NOUN
dti-1318	280	17	of	of	ADP
dti-1318	280	18	unconventional	unconventional	ADJ
dti-1318	280	19	nnrtis	nnrtis	NOUN
dti-1318	280	20	that	that	PRON
dti-1318	280	21	bind	bind	VERB
dti-1318	280	22	to	to	ADP
dti-1318	280	23	hiv-1	hiv-1	X
dti-1318	280	24	rt	rt	PROPN
dti-1318	280	25	and	and	CCONJ
dti-1318	280	26	inhibit	inhibit	VERB
dti-1318	280	27	enzyme	enzyme	NOUN
dti-1318	280	28	activity	activity	NOUN
dti-1318	280	29	by	by	ADP
dti-1318	280	30	decreasing	decrease	VERB
dti-1318	280	31	the	the	DET
dti-1318	280	32	overall	overall	ADJ
dti-1318	280	33	stability	stability	NOUN
dti-1318	280	34	of	of	ADP
dti-1318	280	35	the	the	DET
dti-1318	280	36	heterodimer	heterodimer	NOUN
dti-1318	280	37	without	without	ADP
dti-1318	280	38	dissociating	dissociate	VERB
dti-1318	280	39	the	the	DET
dti-1318	280	40	complex	complex	ADJ
dti-1318	280	41	(	(	PUNCT
dti-1318	280	42	sluis	sluis	NOUN
dti-1318	280	43	-	-	PUNCT
dti-1318	280	44	cremer	cremer	NOUN
dti-1318	280	45	et	et	PROPN
dti-1318	280	46	al	al	PROPN
dti-1318	280	47	.	.	PROPN
dti-1318	280	48	2000	2000	NUM
dti-1318	280	49	;	;	PUNCT
dti-1318	280	50	sluis	sluis	NOUN
dti-1318	280	51	-	-	PUNCT
dti-1318	280	52	cremer	cremer	NOUN
dti-1318	280	53	and	and	CCONJ
dti-1318	280	54	tachedjian	tachedjian	NOUN
dti-1318	280	55	,	,	PUNCT
dti-1318	280	56	2002	2002	NUM
dti-1318	280	57	;	;	PUNCT
dti-1318	280	58	sluis	sluis	NOUN
dti-1318	280	59	-	-	PUNCT
dti-1318	280	60	cremer	cremer	NOUN
dti-1318	280	61	et	et	PROPN
dti-1318	280	62	al	al	PROPN
dti-1318	280	63	.	.	PROPN
dti-1318	280	64	2006	2006	NUM
dti-1318	280	65	;	;	PUNCT
dti-1318	280	66	camarasa	camarasa	VERB
dti-1318	280	67	et	et	PROPN
dti-1318	280	68	al	al	PROPN
dti-1318	280	69	.	.	PROPN
dti-1318	280	70	2006	2006	NUM
dti-1318	280	71	)	)	PUNCT
dti-1318	280	72	.	.	PUNCT
dti-1318	281	1	the	the	DET
dti-1318	281	2	tsao	tsao	PROPN
dti-1318	281	3	-	-	PUNCT
dti-1318	281	4	t	t	NOUN
dti-1318	281	5	derivatives	derivative	NOUN
dti-1318	281	6	(	(	PUNCT
dti-1318	281	7	[	[	X
dti-1318	281	8	2′,5′-bis	2′,5′-bis	ADJ
dti-1318	281	9	-	-	ADJ
dti-1318	281	10	o(tert	o(tert	ADJ
dti-1318	281	11	-	-	PUNCT
dti-1318	281	12	butyldimethylsilyl)-β	butyldimethylsilyl)-β	NOUN
dti-1318	281	13	-	-	PUNCT
dti-1318	281	14	d	d	NOUN
dti-1318	281	15	-	-	PUNCT
dti-1318	281	16	ribofuranosyl]-3′spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide	ribofuranosyl]-3′spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide	NOUN
dti-1318	281	17	)	)	PUNCT
dti-1318	281	18	thymine	thymine	NOUN
dti-1318	281	19	)	)	PUNCT
dti-1318	281	20	destabilise	destabilise	VERB
dti-1318	281	21	both	both	DET
dti-1318	281	22	rt	rt	PROPN
dti-1318	281	23	heterodimers	heterodimer	NOUN
dti-1318	281	24	and	and	CCONJ
dti-1318	281	25	p66	p66	NOUN
dti-1318	281	26	homodimers	homodimer	NOUN
dti-1318	281	27	by	by	ADP
dti-1318	281	28	inducing	induce	VERB
dti-1318	281	29	changes	change	NOUN
dti-1318	281	30	at	at	ADP
dti-1318	281	31	the	the	DET
dti-1318	281	32	rt	rt	PROPN
dti-1318	281	33	dimer	dimer	PROPN
dti-1318	281	34	interface	interface	PROPN
dti-1318	281	35	(	(	PUNCT
dti-1318	281	36	sluis	sluis	NOUN
dti-1318	281	37	-	-	PUNCT
dti-1318	281	38	cremer	cremer	NOUN
dti-1318	281	39	et	et	PROPN
dti-1318	281	40	al	al	PROPN
dti-1318	281	41	.	.	PROPN
dti-1318	281	42	2000	2000	NUM
dti-1318	281	43	;	;	PUNCT
dti-1318	281	44	rodriguezbarrios	rodriguezbarrio	VERB
dti-1318	281	45	et	et	PROPN
dti-1318	281	46	al	al	PROPN
dti-1318	281	47	.	.	PROPN
dti-1318	281	48	2001	2001	NUM
dti-1318	281	49	)	)	PUNCT
dti-1318	281	50	.	.	PUNCT
dti-1318	282	1	the	the	DET
dti-1318	282	2	putative	putative	ADJ
dti-1318	282	3	binding	bind	VERB
dti-1318	282	4	site	site	NOUN
dti-1318	282	5	is	be	AUX
dti-1318	282	6	at	at	ADP
dti-1318	282	7	the	the	DET
dti-1318	282	8	rt	rt	PROPN
dti-1318	282	9	dimer	dimer	PROPN
dti-1318	282	10	interface	interface	NOUN
dti-1318	282	11	and	and	CCONJ
dti-1318	282	12	overlaps	overlap	NOUN
dti-1318	282	13	in	in	ADP
dti-1318	282	14	part	part	NOUN
dti-1318	282	15	with	with	ADP
dti-1318	282	16	the	the	DET
dti-1318	282	17	nnrti	nnrti	NOUN
dti-1318	282	18	binding	bind	VERB
dti-1318	282	19	pocket	pocket	NOUN
dti-1318	282	20	(	(	PUNCT
dti-1318	282	21	rodriguez	rodriguez	NOUN
dti-1318	282	22	-	-	PUNCT
dti-1318	282	23	barrios	barrio	NOUN
dti-1318	282	24	et	et	PROPN
dti-1318	282	25	al	al	PROPN
dti-1318	282	26	.	.	PROPN
dti-1318	282	27	2001	2001	NUM
dti-1318	282	28	)	)	PUNCT
dti-1318	282	29	.	.	PUNCT
dti-1318	283	1	resistance	resistance	NOUN
dti-1318	283	2	mutations	mutation	NOUN
dti-1318	283	3	to	to	ADP
dti-1318	283	4	the	the	DET
dti-1318	283	5	tsao	tsao	PROPN
dti-1318	283	6	drugs	drug	NOUN
dti-1318	283	7	are	be	AUX
dti-1318	283	8	readily	readily	ADV
dti-1318	283	9	generated	generate	VERB
dti-1318	283	10	in	in	ADP
dti-1318	283	11	cell	cell	NOUN
dti-1318	283	12	culture	culture	NOUN
dti-1318	283	13	indicating	indicate	VERB
dti-1318	283	14	that	that	SCONJ
dti-1318	283	15	these	these	DET
dti-1318	283	16	drugs	drug	NOUN
dti-1318	283	17	are	be	AUX
dti-1318	283	18	specific	specific	ADJ
dti-1318	283	19	inhibitors	inhibitor	NOUN
dti-1318	283	20	of	of	ADP
dti-1318	283	21	the	the	DET
dti-1318	283	22	hiv-1	hiv-1	ADJ
dti-1318	283	23	rt	rt	PROPN
dti-1318	283	24	(	(	PUNCT
dti-1318	283	25	balzarini	balzarini	PROPN
dti-1318	283	26	et	et	PROPN
dti-1318	283	27	al	al	PROPN
dti-1318	283	28	.	.	PROPN
dti-1318	283	29	1993	1993	NUM
dti-1318	283	30	)	)	PUNCT
dti-1318	283	31	.	.	PUNCT
dti-1318	284	1	while	while	SCONJ
dti-1318	284	2	tsao	tsao	PROPN
dti-1318	284	3	represent	represent	VERB
dti-1318	284	4	the	the	DET
dti-1318	284	5	fi	fi	NOUN
dti-1318	284	6	rst	rst	ADJ
dti-1318	284	7	class	class	NOUN
dti-1318	284	8	of	of	ADP
dti-1318	284	9	small	small	ADJ
dti-1318	284	10	molecules	molecule	NOUN
dti-1318	284	11	that	that	PRON
dti-1318	284	12	destabilize	destabilize	VERB
dti-1318	284	13	the	the	DET
dti-1318	284	14	rt	rt	PROPN
dti-1318	284	15	heterodimer	heterodimer	NOUN
dti-1318	284	16	,	,	PUNCT
dti-1318	284	17	preclinical	preclinical	ADJ
dti-1318	284	18	studies	study	NOUN
dti-1318	284	19	demonstrate	demonstrate	VERB
dti-1318	284	20	that	that	SCONJ
dti-1318	284	21	the	the	DET
dti-1318	284	22	pharmacological	pharmacological	ADJ
dti-1318	284	23	profile	profile	NOUN
dti-1318	284	24	of	of	ADP
dti-1318	284	25	tsao	tsao	NOUN
dti-1318	284	26	inhibitors	inhibitor	NOUN
dti-1318	284	27	is	be	AUX
dti-1318	284	28	unfavourable	unfavourable	ADJ
dti-1318	284	29	for	for	ADP
dti-1318	284	30	further	further	ADJ
dti-1318	284	31	clinical	clinical	ADJ
dti-1318	284	32	development	development	NOUN
dti-1318	284	33	(	(	PUNCT
dti-1318	284	34	camarasa	camarasa	NOUN
dti-1318	284	35	et	et	PROPN
dti-1318	284	36	al	al	PROPN
dti-1318	284	37	.	.	PROPN
dti-1318	284	38	2006	2006	NUM
dti-1318	284	39	)	)	PUNCT
dti-1318	284	40	.	.	PUNCT
dti-1318	285	1	the	the	DET
dti-1318	285	2	n	n	CCONJ
dti-1318	285	3	-	-	PUNCT
dti-1318	285	4	acylhydrazone	acylhydrazone	NOUN
dti-1318	285	5	derivative	derivative	NOUN
dti-1318	285	6	n-(4	n-(4	NOUN
dti-1318	285	7	-	-	PUNCT
dti-1318	285	8	tertbutylbenzoyl)-2	tertbutylbenzoyl)-2	NOUN
dti-1318	285	9	-	-	PUNCT
dti-1318	285	10	hydroxy-1	hydroxy-1	NOUN
dti-1318	285	11	-	-	PUNCT
dti-1318	285	12	naphthaldehyde	naphthaldehyde	NOUN
dti-1318	285	13	hydrazone	hydrazone	NOUN
dti-1318	285	14	(	(	PUNCT
dti-1318	285	15	bbnh	bbnh	NOUN
dti-1318	285	16	)	)	PUNCT
dti-1318	285	17	binds	bind	VERB
dti-1318	285	18	to	to	ADP
dti-1318	285	19	both	both	CCONJ
dti-1318	285	20	the	the	DET
dti-1318	285	21	dna	dna	PROPN
dti-1318	285	22	polymerase	polymerase	NOUN
dti-1318	285	23	and	and	CCONJ
dti-1318	285	24	rnase	rnase	PROPN
dti-1318	285	25	h	h	PROPN
dti-1318	285	26	domains	domain	NOUN
dti-1318	285	27	of	of	ADP
dti-1318	285	28	rt	rt	PROPN
dti-1318	285	29	and	and	CCONJ
dti-1318	285	30	inhibits	inhibit	VERB
dti-1318	285	31	both	both	DET
dti-1318	285	32	enzymatic	enzymatic	ADJ
dti-1318	285	33	activities	activity	NOUN
dti-1318	285	34	of	of	ADP
dti-1318	285	35	the	the	DET
dti-1318	285	36	rt	rt	PROPN
dti-1318	285	37	(	(	PUNCT
dti-1318	285	38	arion	arion	PROPN
dti-1318	285	39	et	et	PROPN
dti-1318	285	40	al	al	PROPN
dti-1318	285	41	.	.	PROPN
dti-1318	285	42	2002	2002	NUM
dti-1318	285	43	)	)	PUNCT
dti-1318	285	44	.	.	PUNCT
dti-1318	286	1	similar	similar	ADJ
dti-1318	286	2	to	to	ADP
dti-1318	286	3	tsao	tsao	PROPN
dti-1318	286	4	,	,	PUNCT
dti-1318	286	5	bbnh	bbnh	ADJ
dti-1318	286	6	prevents	prevent	VERB
dti-1318	286	7	rt	rt	NOUN
dti-1318	286	8	activity	activity	NOUN
dti-1318	286	9	through	through	ADP
dti-1318	286	10	destabilizing	destabilizing	ADJ
dti-1318	286	11	,	,	PUNCT
dti-1318	286	12	but	but	CCONJ
dti-1318	286	13	not	not	PART
dti-1318	286	14	dissociating	dissociate	VERB
dti-1318	286	15	the	the	DET
dti-1318	286	16	subunits	subunit	NOUN
dti-1318	286	17	.	.	PUNCT
dti-1318	287	1	bbnh	bbnh	ADJ
dti-1318	287	2	derivatives	derivative	NOUN
dti-1318	287	3	that	that	PRON
dti-1318	287	4	bind	bind	VERB
dti-1318	287	5	to	to	ADP
dti-1318	287	6	the	the	DET
dti-1318	287	7	dna	dna	PROPN
dti-1318	287	8	polymerase	polymerase	NOUN
dti-1318	287	9	domain	domain	NOUN
dti-1318	287	10	alone	alone	ADV
dti-1318	287	11	are	be	AUX
dti-1318	287	12	suffi	suffi	NOUN
dti-1318	287	13	cient	cient	NOUN
dti-1318	287	14	to	to	PART
dti-1318	287	15	induce	induce	VERB
dti-1318	287	16	dimer	dimer	NOUN
dti-1318	287	17	destabilization	destabilization	NOUN
dti-1318	287	18	(	(	PUNCT
dti-1318	287	19	sluis	sluis	NOUN
dti-1318	287	20	-	-	PUNCT
dti-1318	287	21	cremer	cremer	NOUN
dti-1318	287	22	and	and	CCONJ
dti-1318	287	23	tachedjian	tachedjian	NOUN
dti-1318	287	24	,	,	PUNCT
dti-1318	287	25	2002	2002	NUM
dti-1318	287	26	)	)	PUNCT
dti-1318	287	27	.	.	PUNCT
dti-1318	288	1	the	the	DET
dti-1318	288	2	recently	recently	ADV
dti-1318	288	3	resolved	resolve	VERB
dti-1318	288	4	structure	structure	NOUN
dti-1318	288	5	of	of	ADP
dti-1318	288	6	hiv-1	hiv-1	X
dti-1318	288	7	rt	rt	PROPN
dti-1318	288	8	bound	bind	VERB
dti-1318	288	9	to	to	ADP
dti-1318	288	10	a	a	DET
dti-1318	288	11	bbnh	bbnh	ADJ
dti-1318	288	12	derivative	derivative	NOUN
dti-1318	288	13	has	have	AUX
dti-1318	288	14	confi	confi	VERB
dti-1318	288	15	rmed	rme	VERB
dti-1318	288	16	that	that	SCONJ
dti-1318	288	17	the	the	DET
dti-1318	288	18	binding	bind	VERB
dti-1318	288	19	site	site	NOUN
dti-1318	288	20	is	be	AUX
dti-1318	288	21	in	in	ADP
dti-1318	288	22	close	close	ADJ
dti-1318	288	23	proximity	proximity	NOUN
dti-1318	288	24	to	to	ADP
dti-1318	288	25	,	,	PUNCT
dti-1318	288	26	but	but	CCONJ
dti-1318	288	27	distinct	distinct	ADJ
dti-1318	288	28	from	from	ADP
dti-1318	288	29	both	both	CCONJ
dti-1318	288	30	the	the	DET
dti-1318	288	31	polymerase	polymerase	NOUN
dti-1318	288	32	active	active	ADJ
dti-1318	288	33	site	site	NOUN
dti-1318	288	34	and	and	CCONJ
dti-1318	288	35	nnibp	nnibp	NOUN
dti-1318	288	36	.	.	PUNCT
dti-1318	289	1	it	it	PRON
dti-1318	289	2	is	be	AUX
dti-1318	289	3	thought	think	VERB
dti-1318	289	4	that	that	SCONJ
dti-1318	289	5	bbnh	bbnh	NOUN
dti-1318	289	6	destabilizes	destabilize	VERB
dti-1318	289	7	the	the	DET
dti-1318	289	8	rt	rt	PROPN
dti-1318	289	9	heterodimer	heterodimer	NOUN
dti-1318	289	10	by	by	ADP
dti-1318	289	11	inducing	induce	VERB
dti-1318	289	12	changes	change	NOUN
dti-1318	289	13	in	in	ADP
dti-1318	289	14	the	the	DET
dti-1318	289	15	primer	primer	NOUN
dti-1318	289	16	-	-	PUNCT
dti-1318	289	17	grip	grip	NOUN
dti-1318	289	18	motif	motif	NOUN
dti-1318	289	19	,	,	PUNCT
dti-1318	289	20	which	which	PRON
dti-1318	289	21	is	be	AUX
dti-1318	289	22	an	an	DET
dti-1318	289	23	important	important	ADJ
dti-1318	289	24	region	region	NOUN
dti-1318	289	25	for	for	ADP
dti-1318	289	26	rt	rt	PROPN
dti-1318	289	27	dimer	dimer	PROPN
dti-1318	289	28	stability	stability	NOUN
dti-1318	289	29	(	(	PUNCT
dti-1318	289	30	himmel	himmel	X
dti-1318	289	31	et	et	PROPN
dti-1318	289	32	al	al	PROPN
dti-1318	289	33	.	.	PROPN
dti-1318	289	34	2006	2006	NUM
dti-1318	289	35	;	;	PUNCT
dti-1318	289	36	srivastava	srivastava	PROPN
dti-1318	289	37	et	et	PROPN
dti-1318	289	38	al	al	PROPN
dti-1318	289	39	.	.	PROPN
dti-1318	289	40	2006	2006	NUM
dti-1318	289	41	)	)	PUNCT
dti-1318	289	42	.	.	PUNCT
dti-1318	290	1	by	by	ADP
dti-1318	290	2	targeting	target	VERB
dti-1318	290	3	the	the	DET
dti-1318	290	4	rt	rt	PROPN
dti-1318	290	5	dimerization	dimerization	NOUN
dti-1318	290	6	interface	interface	NOUN
dti-1318	290	7	,	,	PUNCT
dti-1318	290	8	it	it	PRON
dti-1318	290	9	is	be	AUX
dti-1318	290	10	possible	possible	ADJ
dti-1318	290	11	that	that	SCONJ
dti-1318	290	12	unconventional	unconventional	ADJ
dti-1318	290	13	nnrtis	nnrtis	NOUN
dti-1318	290	14	may	may	AUX
dti-1318	290	15	have	have	VERB
dti-1318	290	16	an	an	DET
dti-1318	290	17	affect	affect	NOUN
dti-1318	290	18	on	on	ADP
dti-1318	290	19	the	the	DET
dti-1318	290	20	late	late	ADJ
dti-1318	290	21	stage	stage	NOUN
dti-1318	290	22	of	of	ADP
dti-1318	290	23	virus	virus	NOUN
dti-1318	290	24	replication	replication	NOUN
dti-1318	290	25	.	.	PUNCT
dti-1318	291	1	in	in	ADP
dti-1318	291	2	particular	particular	ADJ
dti-1318	291	3	,	,	PUNCT
dti-1318	291	4	the	the	DET
dti-1318	291	5	tsao	tsao	PROPN
dti-1318	291	6	drugs	drug	NOUN
dti-1318	291	7	that	that	PRON
dti-1318	291	8	destabilize	destabilize	VERB
dti-1318	291	9	the	the	DET
dti-1318	291	10	p66	p66	NOUN
dti-1318	291	11	homodimer	homodimer	NOUN
dti-1318	291	12	,	,	PUNCT
dti-1318	291	13	may	may	AUX
dti-1318	291	14	also	also	ADV
dti-1318	291	15	perturb	perturb	VERB
dti-1318	291	16	the	the	DET
dti-1318	291	17	process	process	NOUN
dti-1318	291	18	of	of	ADP
dti-1318	291	19	rt	rt	PROPN
dti-1318	291	20	maturation	maturation	NOUN
dti-1318	291	21	to	to	ADP
dti-1318	291	22	the	the	DET
dti-1318	291	23	heterodimer	heterodimer	NOUN
dti-1318	291	24	,	,	PUNCT
dti-1318	291	25	and	and	CCONJ
dti-1318	291	26	arguably	arguably	ADV
dti-1318	291	27	even	even	ADV
dti-1318	291	28	target	target	VERB
dti-1318	291	29	the	the	DET
dti-1318	291	30	rt	rt	PROPN
dti-1318	291	31	domain	domain	NOUN
dti-1318	291	32	in	in	ADP
dti-1318	291	33	gag	gag	NOUN
dti-1318	291	34	-	-	PUNCT
dti-1318	291	35	pol	pol	NOUN
dti-1318	291	36	and	and	CCONJ
dti-1318	291	37	interfere	interfere	VERB
dti-1318	291	38	with	with	ADP
dti-1318	291	39	pr	pr	NOUN
dti-1318	291	40	activation	activation	NOUN
dti-1318	291	41	.	.	PUNCT
dti-1318	292	1	however	however	ADV
dti-1318	292	2	,	,	PUNCT
dti-1318	292	3	these	these	DET
dti-1318	292	4	possible	possible	ADJ
dti-1318	292	5	effects	effect	NOUN
dti-1318	292	6	have	have	AUX
dti-1318	292	7	not	not	PART
dti-1318	292	8	been	be	AUX
dti-1318	292	9	described	describe	VERB
dti-1318	292	10	.	.	PUNCT
dti-1318	293	1	further	further	ADJ
dti-1318	293	2	elucidation	elucidation	NOUN
dti-1318	293	3	of	of	ADP
dti-1318	293	4	the	the	DET
dti-1318	293	5	impact	impact	NOUN
dti-1318	293	6	of	of	ADP
dti-1318	293	7	nonclassical	nonclassical	ADJ
dti-1318	293	8	nnrtis	nnrtis	NOUN
dti-1318	293	9	on	on	ADP
dti-1318	293	10	rt	rt	PROPN
dti-1318	293	11	maturation	maturation	NOUN
dti-1318	293	12	,	,	PUNCT
dti-1318	293	13	and	and	CCONJ
dti-1318	293	14	the	the	DET
dti-1318	293	15	mechanism	mechanism	NOUN
dti-1318	293	16	of	of	ADP
dti-1318	293	17	destabilization	destabilization	NOUN
dti-1318	293	18	would	would	AUX
dti-1318	293	19	be	be	AUX
dti-1318	293	20	advantageous	advantageous	ADJ
dti-1318	293	21	for	for	ADP
dti-1318	293	22	designing	design	VERB
dti-1318	293	23	more	more	ADV
dti-1318	293	24	potent	potent	ADJ
dti-1318	293	25	inhibitors	inhibitor	NOUN
dti-1318	293	26	of	of	ADP
dti-1318	293	27	both	both	CCONJ
dti-1318	293	28	rt	rt	PROPN
dti-1318	293	29	function	function	NOUN
dti-1318	293	30	and	and	CCONJ
dti-1318	293	31	rt	rt	PROPN
dti-1318	293	32	maturation	maturation	NOUN
dti-1318	293	33	.	.	PUNCT
dti-1318	294	1	classical	classical	ADJ
dti-1318	294	2	nnrtis	nnrtis	PROPN
dti-1318	294	3	as	as	SCONJ
dti-1318	294	4	rt	rt	PROPN
dti-1318	294	5	inhibitors	inhibitor	NOUN
dti-1318	294	6	acting	act	VERB
dti-1318	294	7	at	at	ADP
dti-1318	294	8	the	the	DET
dti-1318	294	9	late	late	ADJ
dti-1318	294	10	stage	stage	NOUN
dti-1318	294	11	of	of	ADP
dti-1318	294	12	viral	viral	ADJ
dti-1318	294	13	replication	replication	NOUN
dti-1318	294	14	interestingly	interestingly	ADV
dti-1318	294	15	,	,	PUNCT
dti-1318	294	16	several	several	ADJ
dti-1318	294	17	classical	classical	ADJ
dti-1318	294	18	nnrtis	nnrtis	NOUN
dti-1318	294	19	have	have	AUX
dti-1318	294	20	been	be	AUX
dti-1318	294	21	shown	show	VERB
dti-1318	294	22	to	to	PART
dti-1318	294	23	confer	confer	VERB
dti-1318	294	24	a	a	DET
dti-1318	294	25	concentration	concentration	NOUN
dti-1318	294	26	dependant	dependant	ADJ
dti-1318	294	27	increase	increase	NOUN
dti-1318	294	28	in	in	ADP
dti-1318	294	29	rt	rt	PROPN
dti-1318	294	30	heterodimer	heterodimer	PROPN
dti-1318	294	31	formation	formation	PROPN
dti-1318	294	32	,	,	PUNCT
dti-1318	294	33	corresponding	correspond	VERB
dti-1318	294	34	with	with	ADP
dti-1318	294	35	a	a	DET
dti-1318	294	36	loss	loss	NOUN
dti-1318	294	37	of	of	ADP
dti-1318	294	38	rt	rt	PROPN
dti-1318	294	39	polymerase	polymerase	NOUN
dti-1318	294	40	function	function	NOUN
dti-1318	294	41	(	(	PUNCT
dti-1318	294	42	tachedjian	tachedjian	NOUN
dti-1318	294	43	et	et	PROPN
dti-1318	294	44	al	al	PROPN
dti-1318	294	45	.	.	PROPN
dti-1318	294	46	2001	2001	NUM
dti-1318	294	47	;	;	PUNCT
dti-1318	294	48	venezia	venezia	PROPN
dti-1318	294	49	et	et	PROPN
dti-1318	294	50	al	al	PROPN
dti-1318	294	51	.	.	PROPN
dti-1318	294	52	2006	2006	NUM
dti-1318	294	53	)	)	PUNCT
dti-1318	294	54	.	.	PUNCT
dti-1318	295	1	efavirenz	efavirenz	NOUN
dti-1318	295	2	(	(	PUNCT
dti-1318	295	3	efv	efv	ADJ
dti-1318	295	4	)	)	PUNCT
dti-1318	295	5	is	be	AUX
dti-1318	295	6	a	a	DET
dti-1318	295	7	strong	strong	ADJ
dti-1318	295	8	enhancer	enhancer	NOUN
dti-1318	295	9	of	of	ADP
dti-1318	295	10	rt	rt	PROPN
dti-1318	295	11	dimerization	dimerization	NOUN
dti-1318	295	12	,	,	PUNCT
dti-1318	295	13	and	and	CCONJ
dti-1318	295	14	also	also	ADV
dti-1318	295	15	enhances	enhance	VERB
dti-1318	295	16	the	the	DET
dti-1318	295	17	formation	formation	NOUN
dti-1318	295	18	of	of	ADP
dti-1318	295	19	p66	p66	NOUN
dti-1318	295	20	and	and	CCONJ
dti-1318	295	21	p51	p51	PROPN
dti-1318	295	22	homodimers	homodimer	NOUN
dti-1318	295	23	(	(	PUNCT
dti-1318	295	24	tachedjian	tachedjian	NOUN
dti-1318	295	25	et	et	PROPN
dti-1318	295	26	al	al	PROPN
dti-1318	295	27	.	.	PROPN
dti-1318	295	28	2005a	2005a	NUM
dti-1318	295	29	)	)	PUNCT
dti-1318	295	30	.	.	PUNCT
dti-1318	296	1	the	the	DET
dti-1318	296	2	exact	exact	ADJ
dti-1318	296	3	mechanism	mechanism	NOUN
dti-1318	296	4	for	for	ADP
dti-1318	296	5	increasing	increase	VERB
dti-1318	296	6	rt	rt	PROPN
dti-1318	296	7	subunit	subunit	NOUN
dti-1318	296	8	interactions	interaction	NOUN
dti-1318	296	9	is	be	AUX
dti-1318	296	10	unknown	unknown	ADJ
dti-1318	296	11	but	but	CCONJ
dti-1318	296	12	it	it	PRON
dti-1318	296	13	is	be	AUX
dti-1318	296	14	suspected	suspect	VERB
dti-1318	296	15	that	that	SCONJ
dti-1318	296	16	the	the	DET
dti-1318	296	17	binding	binding	NOUN
dti-1318	296	18	of	of	ADP
dti-1318	296	19	efv	efv	NOUN
dti-1318	296	20	to	to	ADP
dti-1318	296	21	the	the	DET
dti-1318	296	22	rt	rt	PROPN
dti-1318	296	23	mediates	mediate	NOUN
dti-1318	296	24	conformational	conformational	ADJ
dti-1318	296	25	changes	change	NOUN
dti-1318	296	26	in	in	ADP
dti-1318	296	27	the	the	DET
dti-1318	296	28	p66	p66	NOUN
dti-1318	296	29	subunit	subunit	NOUN
dti-1318	296	30	that	that	PRON
dti-1318	296	31	promotes	promote	VERB
dti-1318	296	32	interaction	interaction	NOUN
dti-1318	296	33	with	with	ADP
dti-1318	296	34	p51	p51	PROPN
dti-1318	296	35	(	(	PUNCT
dti-1318	296	36	tachedjian	tachedjian	NOUN
dti-1318	296	37	et	et	PROPN
dti-1318	296	38	al	al	PROPN
dti-1318	296	39	.	.	PROPN
dti-1318	296	40	2001	2001	NUM
dti-1318	296	41	)	)	PUNCT
dti-1318	296	42	.	.	PUNCT
dti-1318	297	1	efv	efv	PROPN
dti-1318	297	2	has	have	AUX
dti-1318	297	3	also	also	ADV
dti-1318	297	4	demonstrated	demonstrate	VERB
dti-1318	297	5	the	the	DET
dti-1318	297	6	capacity	capacity	NOUN
dti-1318	297	7	to	to	PART
dti-1318	297	8	enhance	enhance	VERB
dti-1318	297	9	the	the	DET
dti-1318	297	10	homodimerization	homodimerization	NOUN
dti-1318	297	11	of	of	ADP
dti-1318	297	12	p66	p66	NOUN
dti-1318	297	13	in	in	ADP
dti-1318	297	14	vitro	vitro	NOUN
dti-1318	297	15	,	,	PUNCT
dti-1318	297	16	and	and	CCONJ
dti-1318	297	17	a	a	DET
dti-1318	297	18	90kda	90kda	NOUN
dti-1318	297	19	model	model	NOUN
dti-1318	297	20	pol	pol	NOUN
dti-1318	297	21	protein	protein	NOUN
dti-1318	297	22	in	in	ADP
dti-1318	297	23	an	an	DET
dti-1318	297	24	inducible	inducible	ADJ
dti-1318	297	25	bacterial	bacterial	ADJ
dti-1318	297	26	expression	expression	NOUN
dti-1318	297	27	system	system	NOUN
dti-1318	297	28	(	(	PUNCT
dti-1318	297	29	sluis	sluis	NOUN
dti-1318	297	30	-	-	PUNCT
dti-1318	297	31	cremer	cremer	NOUN
dti-1318	297	32	et	et	PROPN
dti-1318	297	33	al	al	PROPN
dti-1318	297	34	.	.	PROPN
dti-1318	297	35	2004	2004	NUM
dti-1318	297	36	;	;	PUNCT
dti-1318	297	37	tachedjian	tachedjian	NOUN
dti-1318	297	38	et	et	PROPN
dti-1318	297	39	al	al	PROPN
dti-1318	297	40	.	.	PROPN
dti-1318	297	41	2005a	2005a	NUM
dti-1318	297	42	)	)	PUNCT
dti-1318	297	43	.	.	PUNCT
dti-1318	298	1	it	it	PRON
dti-1318	298	2	has	have	AUX
dti-1318	298	3	recently	recently	ADV
dti-1318	298	4	been	be	AUX
dti-1318	298	5	demonstrated	demonstrate	VERB
dti-1318	298	6	that	that	SCONJ
dti-1318	298	7	nnrtis	nnrtis	NOUN
dti-1318	298	8	enhance	enhance	VERB
dti-1318	298	9	gag	gag	NOUN
dti-1318	298	10	-	-	PUNCT
dti-1318	298	11	pol	pol	NOUN
dti-1318	298	12	dimerization	dimerization	NOUN
dti-1318	298	13	,	,	PUNCT
dti-1318	298	14	resulting	result	VERB
dti-1318	298	15	in	in	ADP
dti-1318	298	16	premature	premature	ADJ
dti-1318	298	17	pr	pr	NOUN
dti-1318	298	18	activation	activation	NOUN
dti-1318	298	19	and	and	CCONJ
dti-1318	298	20	a	a	DET
dti-1318	298	21	decrease	decrease	NOUN
dti-1318	298	22	in	in	ADP
dti-1318	298	23	viral	viral	ADJ
dti-1318	298	24	particle	particle	NOUN
dti-1318	298	25	release	release	NOUN
dti-1318	298	26	(	(	PUNCT
dti-1318	298	27	figueiredo	figueiredo	PROPN
dti-1318	298	28	et	et	PROPN
dti-1318	298	29	al	al	PROPN
dti-1318	298	30	.	.	PROPN
dti-1318	298	31	2006	2006	NUM
dti-1318	298	32	)	)	PUNCT
dti-1318	298	33	.	.	PUNCT
dti-1318	299	1	in	in	ADP
dti-1318	299	2	hiv-1	hiv-1	PUNCT
dti-1318	299	3	transfected	transfecte	VERB
dti-1318	299	4	cells	cell	NOUN
dti-1318	299	5	,	,	PUNCT
dti-1318	299	6	efv	efv	ADJ
dti-1318	299	7	,	,	PUNCT
dti-1318	299	8	tmc120	tmc120	ADJ
dti-1318	299	9	and	and	CCONJ
dti-1318	299	10	tmc125	tmc125	PROPN
dti-1318	299	11	increased	increase	VERB
dti-1318	299	12	gag	gag	NOUN
dti-1318	299	13	and	and	CCONJ
dti-1318	299	14	gag	gag	NOUN
dti-1318	299	15	-	-	PUNCT
dti-1318	299	16	pol	pol	NOUN
dti-1318	299	17	processing	processing	NOUN
dti-1318	299	18	,	,	PUNCT
dti-1318	299	19	and	and	CCONJ
dti-1318	299	20	caused	cause	VERB
dti-1318	299	21	up	up	ADP
dti-1318	299	22	to	to	PART
dti-1318	299	23	45	45	NUM
dti-1318	299	24	%	%	NOUN
dti-1318	299	25	decrease	decrease	NOUN
dti-1318	299	26	in	in	ADP
dti-1318	299	27	viral	viral	ADJ
dti-1318	299	28	particle	particle	NOUN
dti-1318	299	29	production	production	NOUN
dti-1318	299	30	.	.	PUNCT
dti-1318	300	1	similar	similar	ADJ
dti-1318	300	2	effects	effect	NOUN
dti-1318	300	3	were	be	AUX
dti-1318	300	4	not	not	PART
dti-1318	300	5	observed	observe	VERB
dti-1318	300	6	for	for	ADP
dti-1318	300	7	nnrtis	nnrtis	NOUN
dti-1318	300	8	that	that	PRON
dti-1318	300	9	do	do	AUX
dti-1318	300	10	not	not	PART
dti-1318	300	11	signifi	signifi	VERB
dti-1318	300	12	cantly	cantly	ADV
dti-1318	300	13	enhance	enhance	VERB
dti-1318	300	14	p66	p66	NOUN
dti-1318	300	15	homodimerization	homodimerization	NOUN
dti-1318	300	16	and	and	CCONJ
dti-1318	300	17	nrtis	nrtis	PROPN
dti-1318	300	18	(	(	PUNCT
dti-1318	300	19	figueiredo	figueiredo	PROPN
dti-1318	300	20	et	et	PROPN
dti-1318	300	21	al	al	PROPN
dti-1318	300	22	.	.	PROPN
dti-1318	300	23	2006	2006	NUM
dti-1318	300	24	)	)	PUNCT
dti-1318	300	25	.	.	PUNCT
dti-1318	301	1	hence	hence	ADV
dti-1318	301	2	,	,	PUNCT
dti-1318	301	3	nnrtis	nnrtis	NOUN
dti-1318	301	4	that	that	PRON
dti-1318	301	5	are	be	AUX
dti-1318	301	6	potent	potent	ADJ
dti-1318	301	7	enhancers	enhancer	NOUN
dti-1318	301	8	of	of	ADP
dti-1318	301	9	rt	rt	NOUN
dti-1318	301	10	dimerization	dimerization	NOUN
dti-1318	301	11	also	also	ADV
dti-1318	301	12	affect	affect	VERB
dti-1318	301	13	the	the	DET
dti-1318	301	14	late	late	ADJ
dti-1318	301	15	stage	stage	NOUN
dti-1318	301	16	of	of	ADP
dti-1318	301	17	viral	viral	ADJ
dti-1318	301	18	replication	replication	NOUN
dti-1318	301	19	,	,	PUNCT
dti-1318	301	20	which	which	PRON
dti-1318	301	21	represents	represent	VERB
dti-1318	301	22	a	a	DET
dti-1318	301	23	novel	novel	ADJ
dti-1318	301	24	inhibitory	inhibitory	ADJ
dti-1318	301	25	mechanism	mechanism	NOUN
dti-1318	301	26	for	for	ADP
dti-1318	301	27	these	these	DET
dti-1318	301	28	drugs	drug	NOUN
dti-1318	301	29	.	.	PUNCT
dti-1318	302	1	however	however	ADV
dti-1318	302	2	,	,	PUNCT
dti-1318	302	3	the	the	DET
dti-1318	302	4	concentrations	concentration	NOUN
dti-1318	302	5	required	require	VERB
dti-1318	302	6	to	to	PART
dti-1318	302	7	mediate	mediate	VERB
dti-1318	302	8	this	this	DET
dti-1318	302	9	effect	effect	NOUN
dti-1318	302	10	are	be	AUX
dti-1318	302	11	two	two	NUM
dti-1318	302	12	to	to	PART
dti-1318	302	13	three	three	NUM
dti-1318	302	14	orders	order	NOUN
dti-1318	302	15	of	of	ADP
dti-1318	302	16	magnitude	magnitude	NOUN
dti-1318	302	17	higher	high	ADJ
dti-1318	302	18	then	then	ADV
dti-1318	302	19	concentrations	concentration	NOUN
dti-1318	302	20	that	that	PRON
dti-1318	302	21	block	block	VERB
dti-1318	302	22	rt	rt	PROPN
dti-1318	302	23	function	function	NOUN
dti-1318	302	24	.	.	PUNCT
dti-1318	303	1	this	this	PRON
dti-1318	303	2	is	be	AUX
dti-1318	303	3	likely	likely	ADJ
dti-1318	303	4	due	due	ADJ
dti-1318	303	5	to	to	ADP
dti-1318	303	6	reduced	reduce	VERB
dti-1318	303	7	binding	bind	VERB
dti-1318	303	8	affi	affi	ADJ
dti-1318	303	9	nity	nity	NOUN
dti-1318	303	10	of	of	ADP
dti-1318	303	11	the	the	DET
dti-1318	303	12	nnrtis	nnrtis	NOUN
dti-1318	303	13	to	to	ADP
dti-1318	303	14	the	the	DET
dti-1318	303	15	proposed	propose	VERB
dti-1318	303	16	target	target	NOUN
dti-1318	303	17	which	which	PRON
dti-1318	303	18	is	be	AUX
dti-1318	303	19	the	the	DET
dti-1318	303	20	rt	rt	PROPN
dti-1318	303	21	domain	domain	NOUN
dti-1318	303	22	of	of	ADP
dti-1318	303	23	gag	gag	NOUN
dti-1318	303	24	-	-	PUNCT
dti-1318	303	25	pol	pol	NOUN
dti-1318	303	26	.	.	PUNCT
dti-1318	304	1	strategies	strategy	NOUN
dti-1318	304	2	to	to	PART
dti-1318	304	3	identify	identify	VERB
dti-1318	304	4	drugs	drug	NOUN
dti-1318	304	5	that	that	PRON
dti-1318	304	6	are	be	AUX
dti-1318	304	7	more	more	ADV
dti-1318	304	8	potent	potent	ADJ
dti-1318	304	9	172	172	NUM
dti-1318	304	10	wapling	waple	VERB
dti-1318	304	11	et	et	PROPN
dti-1318	304	12	al	al	PROPN
dti-1318	304	13	drug	drug	PROPN
dti-1318	304	14	target	target	NOUN
dti-1318	304	15	insights	insight	NOUN
dti-1318	304	16	2007	2007	NUM
dti-1318	304	17	:	:	PUNCT
dti-1318	304	18	2	2	NUM
dti-1318	304	19	inhibitors	inhibitor	NOUN
dti-1318	304	20	of	of	ADP
dti-1318	304	21	this	this	DET
dti-1318	304	22	late	late	ADJ
dti-1318	304	23	stage	stage	NOUN
dti-1318	304	24	in	in	ADP
dti-1318	304	25	the	the	DET
dti-1318	304	26	viral	viral	ADJ
dti-1318	304	27	life	life	NOUN
dti-1318	304	28	-	-	PUNCT
dti-1318	304	29	cycle	cycle	NOUN
dti-1318	304	30	could	could	AUX
dti-1318	304	31	be	be	AUX
dti-1318	304	32	identifi	identifi	PROPN
dti-1318	304	33	ed	ed	NOUN
dti-1318	304	34	by	by	ADP
dti-1318	304	35	screening	screen	VERB
dti-1318	304	36	for	for	ADP
dti-1318	304	37	molecules	molecule	NOUN
dti-1318	304	38	that	that	PRON
dti-1318	304	39	enhance	enhance	VERB
dti-1318	304	40	gag	gag	NOUN
dti-1318	304	41	-	-	PUNCT
dti-1318	304	42	pol	pol	NOUN
dti-1318	304	43	dimerization	dimerization	NOUN
dti-1318	304	44	.	.	PUNCT
dti-1318	305	1	such	such	DET
dti-1318	305	2	a	a	DET
dti-1318	305	3	screen	screen	NOUN
dti-1318	305	4	could	could	AUX
dti-1318	305	5	be	be	AUX
dti-1318	305	6	enhanced	enhance	VERB
dti-1318	305	7	by	by	ADP
dti-1318	305	8	incorporating	incorporate	VERB
dti-1318	305	9	mutations	mutation	NOUN
dti-1318	305	10	in	in	ADP
dti-1318	305	11	the	the	DET
dti-1318	305	12	rt	rt	PROPN
dti-1318	305	13	that	that	PRON
dti-1318	305	14	are	be	AUX
dti-1318	305	15	known	know	VERB
dti-1318	305	16	to	to	PART
dti-1318	305	17	confer	confer	VERB
dti-1318	305	18	decreased	decrease	VERB
dti-1318	305	19	susceptibility	susceptibility	NOUN
dti-1318	305	20	to	to	ADP
dti-1318	305	21	current	current	ADJ
dti-1318	305	22	nnrtis	nnrtis	NOUN
dti-1318	305	23	in	in	ADP
dti-1318	305	24	order	order	NOUN
dti-1318	305	25	to	to	PART
dti-1318	305	26	select	select	VERB
dti-1318	305	27	for	for	ADP
dti-1318	305	28	drugs	drug	NOUN
dti-1318	305	29	that	that	PRON
dti-1318	305	30	have	have	VERB
dti-1318	305	31	the	the	DET
dti-1318	305	32	potential	potential	NOUN
dti-1318	305	33	to	to	PART
dti-1318	305	34	block	block	VERB
dti-1318	305	35	nnrti	nnrti	NOUN
dti-1318	305	36	resistant	resistant	ADJ
dti-1318	305	37	strains	strain	NOUN
dti-1318	305	38	of	of	ADP
dti-1318	305	39	hiv-1	hiv-1	X
dti-1318	305	40	.	.	PUNCT
dti-1318	305	41	peptide	peptide	NOUN
dti-1318	305	42	based	base	VERB
dti-1318	305	43	inhibitors	inhibitor	NOUN
dti-1318	305	44	of	of	ADP
dti-1318	305	45	rt	rt	PROPN
dti-1318	305	46	dimerization	dimerization	NOUN
dti-1318	305	47	two	two	NUM
dti-1318	305	48	strategies	strategy	NOUN
dti-1318	305	49	have	have	AUX
dti-1318	305	50	been	be	AUX
dti-1318	305	51	utilised	utilise	VERB
dti-1318	305	52	to	to	PART
dti-1318	305	53	generate	generate	VERB
dti-1318	305	54	peptides	peptide	NOUN
dti-1318	305	55	designed	design	VERB
dti-1318	305	56	to	to	PART
dti-1318	305	57	target	target	VERB
dti-1318	305	58	the	the	DET
dti-1318	305	59	rt	rt	PROPN
dti-1318	305	60	dimer	dimer	PROPN
dti-1318	305	61	interface	interface	NOUN
dti-1318	305	62	in	in	ADP
dti-1318	305	63	order	order	NOUN
dti-1318	305	64	to	to	PART
dti-1318	305	65	block	block	VERB
dti-1318	305	66	hiv-1	hiv-1	X
dti-1318	305	67	rt	rt	PROPN
dti-1318	305	68	function	function	NOUN
dti-1318	305	69	,	,	PUNCT
dti-1318	305	70	including	include	VERB
dti-1318	305	71	peptides	peptide	NOUN
dti-1318	305	72	corresponding	correspond	VERB
dti-1318	305	73	to	to	ADP
dti-1318	305	74	regions	region	NOUN
dti-1318	305	75	that	that	PRON
dti-1318	305	76	are	be	AUX
dti-1318	305	77	known	know	VERB
dti-1318	305	78	to	to	PART
dti-1318	305	79	have	have	VERB
dti-1318	305	80	an	an	DET
dti-1318	305	81	important	important	ADJ
dti-1318	305	82	role	role	NOUN
dti-1318	305	83	in	in	ADP
dti-1318	305	84	rt	rt	PROPN
dti-1318	305	85	dimerization	dimerization	NOUN
dti-1318	305	86	(	(	PUNCT
dti-1318	305	87	debyser	debyser	NOUN
dti-1318	305	88	and	and	CCONJ
dti-1318	305	89	de	de	X
dti-1318	305	90	clercq	clercq	NOUN
dti-1318	305	91	,	,	PUNCT
dti-1318	305	92	1996	1996	NUM
dti-1318	305	93	;	;	PUNCT
dti-1318	305	94	depollier	depollier	NOUN
dti-1318	305	95	et	et	PROPN
dti-1318	305	96	al	al	PROPN
dti-1318	305	97	.	.	PROPN
dti-1318	305	98	2005	2005	NUM
dti-1318	305	99	;	;	PUNCT
dti-1318	305	100	divita	divita	PROPN
dti-1318	305	101	et	et	PROPN
dti-1318	305	102	al	al	PROPN
dti-1318	305	103	.	.	PROPN
dti-1318	305	104	1994	1994	NUM
dti-1318	305	105	;	;	PUNCT
dti-1318	305	106	morris	morris	PROPN
dti-1318	305	107	et	et	PROPN
dti-1318	305	108	al	al	PROPN
dti-1318	305	109	.	.	PROPN
dti-1318	305	110	1999b	1999b	NUM
dti-1318	305	111	;	;	PUNCT
dti-1318	305	112	morris	morris	PROPN
dti-1318	305	113	et	et	PROPN
dti-1318	305	114	al	al	PROPN
dti-1318	305	115	.	.	PROPN
dti-1318	305	116	1999a	1999a	NUM
dti-1318	305	117	)	)	PUNCT
dti-1318	305	118	.	.	PUNCT
dti-1318	306	1	the	the	DET
dti-1318	306	2	most	most	ADV
dti-1318	306	3	successful	successful	ADJ
dti-1318	306	4	of	of	ADP
dti-1318	306	5	these	these	DET
dti-1318	306	6	peptides	peptide	NOUN
dti-1318	306	7	,	,	PUNCT
dti-1318	306	8	pep-7	pep-7	ADV
dti-1318	306	9	,	,	PUNCT
dti-1318	306	10	corresponds	correspond	VERB
dti-1318	306	11	to	to	ADP
dti-1318	306	12	rt	rt	PROPN
dti-1318	306	13	residues	residue	NOUN
dti-1318	306	14	395–404	395–404	NUM
dti-1318	306	15	,	,	PUNCT
dti-1318	306	16	derived	derive	VERB
dti-1318	306	17	from	from	ADP
dti-1318	306	18	the	the	DET
dti-1318	306	19	highly	highly	ADV
dti-1318	306	20	conserved	conserved	ADJ
dti-1318	306	21	tryptophan	tryptophan	NOUN
dti-1318	306	22	repeat	repeat	NOUN
dti-1318	306	23	motif	motif	NOUN
dti-1318	306	24	(	(	PUNCT
dti-1318	306	25	w398	w398	PROPN
dti-1318	306	26	–	–	PUNCT
dti-1318	306	27	w414	w414	NUM
dti-1318	306	28	)	)	PUNCT
dti-1318	306	29	(	(	PUNCT
dti-1318	306	30	depollier	depollier	NOUN
dti-1318	306	31	et	et	PROPN
dti-1318	306	32	al	al	PROPN
dti-1318	306	33	.	.	PROPN
dti-1318	306	34	2005	2005	NUM
dti-1318	306	35	)	)	PUNCT
dti-1318	306	36	.	.	PUNCT
dti-1318	307	1	pep-7	pep-7	PUNCT
dti-1318	307	2	interacts	interact	VERB
dti-1318	307	3	with	with	ADP
dti-1318	307	4	p51	p51	PROPN
dti-1318	307	5	,	,	PUNCT
dti-1318	307	6	and	and	CCONJ
dti-1318	307	7	destablizes	destablize	VERB
dti-1318	307	8	both	both	CCONJ
dti-1318	307	9	the	the	DET
dti-1318	307	10	rt	rt	PROPN
dti-1318	307	11	heterodimer	heterodimer	NOUN
dti-1318	307	12	and	and	CCONJ
dti-1318	307	13	the	the	DET
dti-1318	307	14	p66	p66	NOUN
dti-1318	307	15	homodimer	homodimer	NOUN
dti-1318	307	16	.	.	PUNCT
dti-1318	307	17	similar	similar	ADJ
dti-1318	307	18	to	to	ADP
dti-1318	307	19	unconventional	unconventional	ADJ
dti-1318	307	20	nnrtis	nnrtis	NOUN
dti-1318	307	21	,	,	PUNCT
dti-1318	307	22	pep-7	pep-7	PUNCT
dti-1318	307	23	is	be	AUX
dti-1318	307	24	unable	unable	ADJ
dti-1318	307	25	to	to	PART
dti-1318	307	26	induce	induce	VERB
dti-1318	307	27	rt	rt	PROPN
dti-1318	307	28	dissociation	dissociation	NOUN
dti-1318	307	29	(	(	PUNCT
dti-1318	307	30	depollier	depollier	NOUN
dti-1318	307	31	et	et	PROPN
dti-1318	307	32	al	al	PROPN
dti-1318	307	33	.	.	PROPN
dti-1318	307	34	2005	2005	NUM
dti-1318	307	35	)	)	PUNCT
dti-1318	307	36	.	.	PUNCT
dti-1318	308	1	pep-7	pep-7	ADV
dti-1318	308	2	based	base	VERB
dti-1318	308	3	peptides	peptide	NOUN
dti-1318	308	4	are	be	AUX
dti-1318	308	5	potent	potent	ADJ
dti-1318	308	6	suppressors	suppressor	NOUN
dti-1318	308	7	of	of	ADP
dti-1318	308	8	hiv-1	hiv-1	X
dti-1318	308	9	replication	replication	NOUN
dti-1318	308	10	at	at	ADP
dti-1318	308	11	noncytotoxic	noncytotoxic	ADJ
dti-1318	308	12	concentrations	concentration	NOUN
dti-1318	308	13	(	(	PUNCT
dti-1318	308	14	morris	morris	PROPN
dti-1318	308	15	et	et	PROPN
dti-1318	308	16	al	al	PROPN
dti-1318	308	17	.	.	PROPN
dti-1318	308	18	1999b	1999b	NUM
dti-1318	308	19	)	)	PUNCT
dti-1318	308	20	.	.	PUNCT
dti-1318	309	1	the	the	DET
dti-1318	309	2	method	method	NOUN
dti-1318	309	3	of	of	ADP
dti-1318	309	4	inhibition	inhibition	NOUN
dti-1318	309	5	in	in	ADP
dti-1318	309	6	hiv-1	hiv-1	PUNCT
dti-1318	309	7	infected	infected	ADJ
dti-1318	309	8	cells	cell	NOUN
dti-1318	309	9	has	have	AUX
dti-1318	309	10	not	not	PART
dti-1318	309	11	been	be	AUX
dti-1318	309	12	elucidated	elucidate	VERB
dti-1318	309	13	.	.	PUNCT
dti-1318	310	1	however	however	ADV
dti-1318	310	2	,	,	PUNCT
dti-1318	310	3	given	give	VERB
dti-1318	310	4	that	that	PRON
dti-1318	310	5	pep-7	pep-7	PUNCT
dti-1318	310	6	can	can	AUX
dti-1318	310	7	not	not	PART
dti-1318	310	8	induce	induce	VERB
dti-1318	310	9	rt	rt	NOUN
dti-1318	310	10	subunit	subunit	NOUN
dti-1318	310	11	dissociation	dissociation	NOUN
dti-1318	310	12	,	,	PUNCT
dti-1318	310	13	it	it	PRON
dti-1318	310	14	has	have	AUX
dti-1318	310	15	been	be	AUX
dti-1318	310	16	suggested	suggest	VERB
dti-1318	310	17	that	that	SCONJ
dti-1318	310	18	it	it	PRON
dti-1318	310	19	acts	act	VERB
dti-1318	310	20	at	at	ADP
dti-1318	310	21	the	the	DET
dti-1318	310	22	late	late	ADJ
dti-1318	310	23	stage	stage	NOUN
dti-1318	310	24	of	of	ADP
dti-1318	310	25	virus	virus	NOUN
dti-1318	310	26	replication	replication	NOUN
dti-1318	310	27	by	by	ADP
dti-1318	310	28	preventing	prevent	VERB
dti-1318	310	29	the	the	DET
dti-1318	310	30	formation	formation	NOUN
dti-1318	310	31	of	of	ADP
dti-1318	310	32	an	an	DET
dti-1318	310	33	active	active	ADJ
dti-1318	310	34	rt	rt	PROPN
dti-1318	310	35	heterodimer	heterodimer	NOUN
dti-1318	310	36	(	(	PUNCT
dti-1318	310	37	morris	morris	PROPN
dti-1318	310	38	et	et	PROPN
dti-1318	310	39	al	al	PROPN
dti-1318	310	40	.	.	PROPN
dti-1318	310	41	1999b	1999b	NUM
dti-1318	310	42	)	)	PUNCT
dti-1318	310	43	.	.	PUNCT
dti-1318	311	1	rational	rational	ADJ
dti-1318	311	2	strategies	strategy	NOUN
dti-1318	311	3	utilising	utilise	VERB
dti-1318	311	4	the	the	DET
dti-1318	311	5	available	available	ADJ
dti-1318	311	6	rt	rt	PROPN
dti-1318	311	7	structures	structure	NOUN
dti-1318	311	8	to	to	PART
dti-1318	311	9	direct	direct	VERB
dti-1318	311	10	the	the	DET
dti-1318	311	11	design	design	NOUN
dti-1318	311	12	and	and	CCONJ
dti-1318	311	13	manufacture	manufacture	NOUN
dti-1318	311	14	of	of	ADP
dti-1318	311	15	mimetic	mimetic	ADJ
dti-1318	311	16	peptides	peptide	NOUN
dti-1318	311	17	targeting	target	VERB
dti-1318	311	18	subunit	subunit	NOUN
dti-1318	311	19	interaction	interaction	NOUN
dti-1318	311	20	is	be	AUX
dti-1318	311	21	a	a	DET
dti-1318	311	22	recent	recent	ADJ
dti-1318	311	23	development	development	NOUN
dti-1318	311	24	(	(	PUNCT
dti-1318	311	25	campbell	campbell	PROPN
dti-1318	311	26	et	et	PROPN
dti-1318	311	27	al	al	PROPN
dti-1318	311	28	.	.	PROPN
dti-1318	311	29	2002	2002	NUM
dti-1318	311	30	;	;	PUNCT
dti-1318	311	31	hosokawa	hosokawa	PROPN
dti-1318	311	32	et	et	PROPN
dti-1318	311	33	al	al	PROPN
dti-1318	311	34	.	.	PROPN
dti-1318	311	35	2004	2004	NUM
dti-1318	311	36	)	)	PUNCT
dti-1318	311	37	.	.	PUNCT
dti-1318	312	1	these	these	DET
dti-1318	312	2	studies	study	NOUN
dti-1318	312	3	have	have	AUX
dti-1318	312	4	led	lead	VERB
dti-1318	312	5	to	to	ADP
dti-1318	312	6	the	the	DET
dti-1318	312	7	synthesis	synthesis	NOUN
dti-1318	312	8	of	of	ADP
dti-1318	312	9	a	a	DET
dti-1318	312	10	peptide	peptide	NOUN
dti-1318	312	11	,	,	PUNCT
dti-1318	312	12	tlma2993	tlma2993	PROPN
dti-1318	312	13	,	,	PUNCT
dti-1318	312	14	which	which	PRON
dti-1318	312	15	also	also	ADV
dti-1318	312	16	targets	target	VERB
dti-1318	312	17	the	the	DET
dti-1318	312	18	rt	rt	PROPN
dti-1318	312	19	connection	connection	NOUN
dti-1318	312	20	subdomain	subdomain	NOUN
dti-1318	312	21	.	.	PUNCT
dti-1318	313	1	tlma2993	tlma2993	PROPN
dti-1318	313	2	inhibits	inhibit	VERB
dti-1318	313	3	rt	rt	NOUN
dti-1318	313	4	activity	activity	NOUN
dti-1318	313	5	at	at	ADP
dti-1318	313	6	micromolar	micromolar	ADJ
dti-1318	313	7	concentrations	concentration	NOUN
dti-1318	313	8	(	(	PUNCT
dti-1318	313	9	campbell	campbell	PROPN
dti-1318	313	10	et	et	PROPN
dti-1318	313	11	al	al	PROPN
dti-1318	313	12	.	.	PROPN
dti-1318	313	13	2002	2002	NUM
dti-1318	313	14	)	)	PUNCT
dti-1318	313	15	.	.	PUNCT
dti-1318	314	1	cells	cell	NOUN
dti-1318	314	2	stably	stably	ADV
dti-1318	314	3	transfected	transfecte	VERB
dti-1318	314	4	with	with	ADP
dti-1318	314	5	this	this	DET
dti-1318	314	6	peptide	peptide	NOUN
dti-1318	314	7	are	be	AUX
dti-1318	314	8	protected	protect	VERB
dti-1318	314	9	from	from	ADP
dti-1318	314	10	hiv-1	hiv-1	ADJ
dti-1318	314	11	infection	infection	NOUN
dti-1318	314	12	in	in	ADP
dti-1318	314	13	a	a	DET
dti-1318	314	14	concentration	concentration	NOUN
dti-1318	314	15	dependant	dependant	ADJ
dti-1318	314	16	manner	manner	NOUN
dti-1318	314	17	due	due	ADP
dti-1318	314	18	to	to	ADP
dti-1318	314	19	inhibition	inhibition	NOUN
dti-1318	314	20	of	of	ADP
dti-1318	314	21	reverse	reverse	ADJ
dti-1318	314	22	transcription	transcription	NOUN
dti-1318	314	23	,	,	PUNCT
dti-1318	314	24	as	as	SCONJ
dti-1318	314	25	observed	observe	VERB
dti-1318	314	26	by	by	ADP
dti-1318	314	27	a	a	DET
dti-1318	314	28	decrease	decrease	NOUN
dti-1318	314	29	in	in	ADP
dti-1318	314	30	hiv-1	hiv-1	PUNCT
dti-1318	314	31	dna	dna	PROPN
dti-1318	314	32	(	(	PUNCT
dti-1318	314	33	hosokawa	hosokawa	NOUN
dti-1318	314	34	et	et	PROPN
dti-1318	314	35	al	al	PROPN
dti-1318	314	36	.	.	PROPN
dti-1318	314	37	2004	2004	NUM
dti-1318	314	38	)	)	PUNCT
dti-1318	314	39	.	.	PUNCT
dti-1318	315	1	targeting	target	VERB
dti-1318	315	2	the	the	PRON
dti-1318	315	3	in	in	ADP
dti-1318	315	4	domain	domain	NOUN
dti-1318	315	5	in	in	ADP
dti-1318	315	6	gag	gag	NOUN
dti-1318	315	7	-	-	PUNCT
dti-1318	315	8	pol	pol	NOUN
dti-1318	315	9	in	in	ADP
dti-1318	315	10	catalyses	catalysis	NOUN
dti-1318	315	11	the	the	DET
dti-1318	315	12	insertion	insertion	NOUN
dti-1318	315	13	of	of	ADP
dti-1318	315	14	viral	viral	ADJ
dti-1318	315	15	dna	dna	NOUN
dti-1318	315	16	into	into	ADP
dti-1318	315	17	the	the	DET
dti-1318	315	18	host	host	NOUN
dti-1318	315	19	chromosome	chromosome	NOUN
dti-1318	315	20	and	and	CCONJ
dti-1318	315	21	thus	thus	ADV
dti-1318	315	22	inhibits	inhibit	VERB
dti-1318	315	23	an	an	DET
dti-1318	315	24	early	early	ADJ
dti-1318	315	25	crucial	crucial	ADJ
dti-1318	315	26	step	step	NOUN
dti-1318	315	27	in	in	ADP
dti-1318	315	28	the	the	DET
dti-1318	315	29	virus	virus	NOUN
dti-1318	315	30	life	life	NOUN
dti-1318	315	31	cycle	cycle	NOUN
dti-1318	315	32	.	.	PUNCT
dti-1318	316	1	in	in	ADP
dti-1318	316	2	is	be	AUX
dti-1318	316	3	also	also	ADV
dti-1318	316	4	implicated	implicate	VERB
dti-1318	316	5	in	in	ADP
dti-1318	316	6	reverse	reverse	ADJ
dti-1318	316	7	transcription	transcription	NOUN
dti-1318	316	8	,	,	PUNCT
dti-1318	316	9	nuclear	nuclear	ADJ
dti-1318	316	10	import	import	NOUN
dti-1318	316	11	of	of	ADP
dti-1318	316	12	the	the	DET
dti-1318	316	13	pre	pre	ADJ
dti-1318	316	14	-	-	ADJ
dti-1318	316	15	integration	integration	NOUN
dti-1318	316	16	complex	complex	ADJ
dti-1318	316	17	,	,	PUNCT
dti-1318	316	18	viral	viral	ADJ
dti-1318	316	19	assembly	assembly	NOUN
dti-1318	316	20	and	and	CCONJ
dti-1318	316	21	budding	bud	VERB
dti-1318	316	22	(	(	PUNCT
dti-1318	316	23	engelman	engelman	NOUN
dti-1318	316	24	et	et	PROPN
dti-1318	316	25	al	al	PROPN
dti-1318	316	26	.	.	PROPN
dti-1318	316	27	1995	1995	NUM
dti-1318	316	28	;	;	PUNCT
dti-1318	316	29	hehl	hehl	VERB
dti-1318	316	30	et	et	PROPN
dti-1318	316	31	al	al	PROPN
dti-1318	316	32	.	.	PROPN
dti-1318	316	33	2004	2004	NUM
dti-1318	316	34	)	)	PUNCT
dti-1318	316	35	.	.	PUNCT
dti-1318	317	1	despite	despite	SCONJ
dti-1318	317	2	the	the	DET
dti-1318	317	3	numerous	numerous	ADJ
dti-1318	317	4	roles	role	NOUN
dti-1318	317	5	of	of	ADP
dti-1318	317	6	in	in	ADP
dti-1318	317	7	in	in	ADP
dti-1318	317	8	hiv-1	hiv-1	X
dti-1318	317	9	replication	replication	NOUN
dti-1318	317	10	,	,	PUNCT
dti-1318	317	11	new	new	ADJ
dti-1318	317	12	approaches	approach	NOUN
dti-1318	317	13	for	for	ADP
dti-1318	317	14	inhibiting	inhibit	VERB
dti-1318	317	15	viral	viral	ADJ
dti-1318	317	16	replication	replication	NOUN
dti-1318	317	17	have	have	AUX
dti-1318	317	18	focused	focus	VERB
dti-1318	317	19	on	on	ADP
dti-1318	317	20	targeting	target	VERB
dti-1318	317	21	the	the	DET
dti-1318	317	22	catalytic	catalytic	ADJ
dti-1318	317	23	activity	activity	NOUN
dti-1318	317	24	of	of	ADP
dti-1318	317	25	in	in	ADP
dti-1318	317	26	that	that	PRON
dti-1318	317	27	is	be	AUX
dti-1318	317	28	required	require	VERB
dti-1318	317	29	for	for	ADP
dti-1318	317	30	proviral	proviral	ADJ
dti-1318	317	31	dna	dna	PROPN
dti-1318	317	32	integration	integration	NOUN
dti-1318	317	33	.	.	PUNCT
dti-1318	318	1	two	two	NUM
dti-1318	318	2	in	in	ADP
dti-1318	318	3	inhibitors	inhibitor	NOUN
dti-1318	318	4	,	,	PUNCT
dti-1318	318	5	mk-0518	mk-0518	NOUN
dti-1318	318	6	and	and	CCONJ
dti-1318	318	7	gs-9137	gs-9137	PROPN
dti-1318	318	8	(	(	PUNCT
dti-1318	318	9	jtk-303	jtk-303	NOUN
dti-1318	318	10	)	)	PUNCT
dti-1318	318	11	have	have	AUX
dti-1318	318	12	entered	enter	VERB
dti-1318	318	13	clinical	clinical	ADJ
dti-1318	318	14	trials	trial	NOUN
dti-1318	318	15	(	(	PUNCT
dti-1318	318	16	cotelle	cotelle	NOUN
dti-1318	318	17	,	,	PUNCT
dti-1318	318	18	2006	2006	NUM
dti-1318	318	19	;	;	PUNCT
dti-1318	318	20	makhija	makhija	NOUN
dti-1318	318	21	,	,	PUNCT
dti-1318	318	22	2006	2006	NUM
dti-1318	318	23	)	)	PUNCT
dti-1318	318	24	and	and	CCONJ
dti-1318	318	25	have	have	AUX
dti-1318	318	26	shown	show	VERB
dti-1318	318	27	effi	effi	PROPN
dti-1318	318	28	cacy	cacy	NOUN
dti-1318	318	29	in	in	ADP
dti-1318	318	30	phase	phase	NOUN
dti-1318	318	31	iii	iii	NUM
dti-1318	318	32	clinical	clinical	ADJ
dti-1318	318	33	trials	trial	NOUN
dti-1318	318	34	(	(	PUNCT
dti-1318	318	35	stephenson	stephenson	NOUN
dti-1318	318	36	,	,	PUNCT
dti-1318	318	37	2007	2007	NUM
dti-1318	318	38	)	)	PUNCT
dti-1318	318	39	.	.	PUNCT
dti-1318	319	1	since	since	SCONJ
dti-1318	319	2	in	in	ADV
dti-1318	319	3	is	be	AUX
dti-1318	319	4	expressed	express	VERB
dti-1318	319	5	as	as	ADP
dti-1318	319	6	part	part	NOUN
dti-1318	319	7	of	of	ADP
dti-1318	319	8	gag	gag	NOUN
dti-1318	319	9	-	-	PUNCT
dti-1318	319	10	pol	pol	NOUN
dti-1318	319	11	,	,	PUNCT
dti-1318	319	12	agents	agent	NOUN
dti-1318	319	13	that	that	PRON
dti-1318	319	14	bind	bind	VERB
dti-1318	319	15	to	to	ADP
dti-1318	319	16	the	the	PRON
dti-1318	319	17	in	in	ADP
dti-1318	319	18	domain	domain	NOUN
dti-1318	319	19	in	in	ADP
dti-1318	319	20	this	this	DET
dti-1318	319	21	polyprotein	polyprotein	NOUN
dti-1318	319	22	are	be	AUX
dti-1318	319	23	likely	likely	ADJ
dti-1318	319	24	to	to	PART
dti-1318	319	25	impact	impact	VERB
dti-1318	319	26	on	on	ADP
dti-1318	319	27	the	the	DET
dti-1318	319	28	late	late	ADJ
dti-1318	319	29	stages	stage	NOUN
dti-1318	319	30	of	of	ADP
dti-1318	319	31	replication	replication	NOUN
dti-1318	319	32	.	.	PUNCT
dti-1318	320	1	consistent	consistent	ADJ
dti-1318	320	2	with	with	ADP
dti-1318	320	3	this	this	DET
dti-1318	320	4	notion	notion	NOUN
dti-1318	320	5	,	,	PUNCT
dti-1318	320	6	mutations	mutation	NOUN
dti-1318	320	7	in	in	ADV
dti-1318	320	8	in	in	ADP
dti-1318	320	9	have	have	AUX
dti-1318	320	10	been	be	AUX
dti-1318	320	11	reported	report	VERB
dti-1318	320	12	to	to	PART
dti-1318	320	13	effect	effect	VERB
dti-1318	320	14	virion	virion	NOUN
dti-1318	320	15	formation	formation	NOUN
dti-1318	320	16	(	(	PUNCT
dti-1318	320	17	shin	shin	NOUN
dti-1318	320	18	et	et	PROPN
dti-1318	320	19	al	al	PROPN
dti-1318	320	20	.	.	PROPN
dti-1318	320	21	1994	1994	NUM
dti-1318	320	22	)	)	PUNCT
dti-1318	320	23	.	.	PUNCT
dti-1318	321	1	truncations	truncation	NOUN
dti-1318	321	2	of	of	ADP
dti-1318	321	3	in	in	ADP
dti-1318	321	4	at	at	ADP
dti-1318	321	5	the	the	DET
dti-1318	321	6	c	c	NOUN
dti-1318	321	7	-	-	PUNCT
dti-1318	321	8	terminus	terminus	NOUN
dti-1318	321	9	of	of	ADP
dti-1318	321	10	gag	gag	NOUN
dti-1318	321	11	-	-	PUNCT
dti-1318	321	12	pol	pol	NOUN
dti-1318	321	13	result	result	NOUN
dti-1318	321	14	in	in	ADP
dti-1318	321	15	aberrant	aberrant	ADJ
dti-1318	321	16	virion	virion	NOUN
dti-1318	321	17	core	core	NOUN
dti-1318	321	18	structures	structure	NOUN
dti-1318	321	19	,	,	PUNCT
dti-1318	321	20	with	with	ADP
dti-1318	321	21	a	a	DET
dti-1318	321	22	reduction	reduction	NOUN
dti-1318	321	23	in	in	ADP
dti-1318	321	24	the	the	DET
dti-1318	321	25	overall	overall	ADJ
dti-1318	321	26	levels	level	NOUN
dti-1318	321	27	of	of	ADP
dti-1318	321	28	cell	cell	NOUN
dti-1318	321	29	-	-	PUNCT
dti-1318	321	30	associated	associate	VERB
dti-1318	321	31	viral	viral	ADJ
dti-1318	321	32	gag	gag	NOUN
dti-1318	321	33	,	,	PUNCT
dti-1318	321	34	suggesting	suggest	VERB
dti-1318	321	35	a	a	DET
dti-1318	321	36	defect	defect	NOUN
dti-1318	321	37	in	in	ADP
dti-1318	321	38	gag	gag	NOUN
dti-1318	321	39	-	-	PUNCT
dti-1318	321	40	pol	pol	NOUN
dti-1318	321	41	processing	processing	NOUN
dti-1318	321	42	(	(	PUNCT
dti-1318	321	43	engelman	engelman	PROPN
dti-1318	321	44	et	et	PROPN
dti-1318	321	45	al	al	PROPN
dti-1318	321	46	.	.	PROPN
dti-1318	321	47	1995	1995	NUM
dti-1318	321	48	;	;	PUNCT
dti-1318	321	49	bukovsky	bukovsky	NOUN
dti-1318	321	50	and	and	CCONJ
dti-1318	321	51	gottlinger	gottlinger	NOUN
dti-1318	321	52	,	,	PUNCT
dti-1318	321	53	1996	1996	NUM
dti-1318	321	54	)	)	PUNCT
dti-1318	321	55	.	.	PUNCT
dti-1318	322	1	in	in	ADP
dti-1318	322	2	requires	require	VERB
dti-1318	322	3	oligomerization	oligomerization	NOUN
dti-1318	322	4	for	for	ADP
dti-1318	322	5	activity	activity	NOUN
dti-1318	322	6	.	.	PUNCT
dti-1318	323	1	therefore	therefore	ADV
dti-1318	323	2	,	,	PUNCT
dti-1318	323	3	inhibitors	inhibitor	NOUN
dti-1318	323	4	of	of	ADP
dti-1318	323	5	in	in	ADP
dti-1318	323	6	function	function	NOUN
dti-1318	323	7	that	that	PRON
dti-1318	323	8	mediate	mediate	VERB
dti-1318	323	9	their	their	PRON
dti-1318	323	10	effects	effect	NOUN
dti-1318	323	11	through	through	ADP
dti-1318	323	12	negating	negating	NOUN
dti-1318	323	13	in	in	ADP
dti-1318	323	14	subunit	subunit	NOUN
dti-1318	323	15	interactions	interaction	NOUN
dti-1318	323	16	are	be	AUX
dti-1318	323	17	also	also	ADV
dti-1318	323	18	likely	likely	ADJ
dti-1318	323	19	to	to	PART
dti-1318	323	20	interfere	interfere	VERB
dti-1318	323	21	with	with	ADP
dti-1318	323	22	viral	viral	ADJ
dti-1318	323	23	assembly	assembly	NOUN
dti-1318	323	24	.	.	PUNCT
dti-1318	324	1	this	this	PRON
dti-1318	324	2	would	would	AUX
dti-1318	324	3	be	be	AUX
dti-1318	324	4	manifested	manifest	VERB
dti-1318	324	5	by	by	ADP
dti-1318	324	6	interfering	interfere	VERB
dti-1318	324	7	with	with	ADP
dti-1318	324	8	gag	gag	NOUN
dti-1318	324	9	-	-	PUNCT
dti-1318	324	10	pol	pol	NOUN
dti-1318	324	11	/	/	SYM
dti-1318	324	12	gag	gag	NOUN
dti-1318	324	13	-	-	PUNCT
dti-1318	324	14	pol	pol	NOUN
dti-1318	324	15	interactions	interaction	NOUN
dti-1318	324	16	leading	lead	VERB
dti-1318	324	17	to	to	ADP
dti-1318	324	18	subsequent	subsequent	ADJ
dti-1318	324	19	effects	effect	NOUN
dti-1318	324	20	on	on	ADP
dti-1318	324	21	hiv-1	hiv-1	X
dti-1318	324	22	pr	pr	NOUN
dti-1318	324	23	activation	activation	NOUN
dti-1318	324	24	(	(	PUNCT
dti-1318	324	25	muriaux	muriaux	NOUN
dti-1318	324	26	et	et	PROPN
dti-1318	324	27	al	al	PROPN
dti-1318	324	28	.	.	PROPN
dti-1318	324	29	2004	2004	NUM
dti-1318	324	30	)	)	PUNCT
dti-1318	324	31	.	.	PUNCT
dti-1318	325	1	in	in	ADP
dti-1318	325	2	this	this	DET
dti-1318	325	3	regard	regard	NOUN
dti-1318	325	4	peptide	peptide	NOUN
dti-1318	325	5	inhibitors	inhibitor	NOUN
dti-1318	325	6	of	of	ADP
dti-1318	325	7	in	in	ADP
dti-1318	325	8	dimerization	dimerization	NOUN
dti-1318	325	9	have	have	AUX
dti-1318	325	10	been	be	AUX
dti-1318	325	11	reported	report	VERB
dti-1318	325	12	,	,	PUNCT
dti-1318	325	13	however	however	ADV
dti-1318	325	14	their	their	PRON
dti-1318	325	15	effects	effect	NOUN
dti-1318	325	16	on	on	ADP
dti-1318	325	17	the	the	DET
dti-1318	325	18	late	late	ADJ
dti-1318	325	19	stages	stage	NOUN
dti-1318	325	20	of	of	ADP
dti-1318	325	21	the	the	DET
dti-1318	325	22	virus	virus	NOUN
dti-1318	325	23	life	life	NOUN
dti-1318	325	24	-	-	PUNCT
dti-1318	325	25	cycle	cycle	NOUN
dti-1318	325	26	remains	remain	VERB
dti-1318	325	27	to	to	PART
dti-1318	325	28	be	be	AUX
dti-1318	325	29	determined	determine	VERB
dti-1318	325	30	(	(	PUNCT
dti-1318	325	31	maroun	maroun	INTJ
dti-1318	325	32	et	et	PROPN
dti-1318	325	33	al	al	PROPN
dti-1318	325	34	.	.	PROPN
dti-1318	325	35	2001	2001	NUM
dti-1318	325	36	;	;	PUNCT
dti-1318	325	37	zhao	zhao	PROPN
dti-1318	325	38	et	et	PROPN
dti-1318	325	39	al	al	PROPN
dti-1318	325	40	.	.	PROPN
dti-1318	325	41	2003	2003	NUM
dti-1318	325	42	)	)	PUNCT
dti-1318	325	43	.	.	PUNCT
dti-1318	326	1	certain	certain	ADJ
dti-1318	326	2	host	host	NOUN
dti-1318	326	3	cell	cell	NOUN
dti-1318	326	4	factors	factor	NOUN
dti-1318	326	5	are	be	AUX
dti-1318	326	6	incorporated	incorporate	VERB
dti-1318	326	7	into	into	ADP
dti-1318	326	8	the	the	DET
dti-1318	326	9	virion	virion	NOUN
dti-1318	326	10	by	by	ADP
dti-1318	326	11	interaction	interaction	NOUN
dti-1318	326	12	with	with	ADP
dti-1318	326	13	the	the	PRON
dti-1318	326	14	in	in	ADP
dti-1318	326	15	domain	domain	NOUN
dti-1318	326	16	of	of	ADP
dti-1318	326	17	gag	gag	NOUN
dti-1318	326	18	-	-	PUNCT
dti-1318	326	19	pol	pol	NOUN
dti-1318	326	20	.	.	PUNCT
dti-1318	327	1	a	a	DET
dti-1318	327	2	cellular	cellular	ADJ
dti-1318	327	3	factor	factor	NOUN
dti-1318	327	4	that	that	PRON
dti-1318	327	5	has	have	AUX
dti-1318	327	6	been	be	AUX
dti-1318	327	7	implicated	implicate	VERB
dti-1318	327	8	in	in	ADP
dti-1318	327	9	affecting	affect	VERB
dti-1318	327	10	the	the	DET
dti-1318	327	11	late	late	ADJ
dti-1318	327	12	stage	stage	NOUN
dti-1318	327	13	of	of	ADP
dti-1318	327	14	the	the	DET
dti-1318	327	15	virus	virus	NOUN
dti-1318	327	16	life	life	NOUN
dti-1318	327	17	cycle	cycle	NOUN
dti-1318	327	18	is	be	AUX
dti-1318	327	19	integrase	integrase	NOUN
dti-1318	327	20	interactor	interactor	NOUN
dti-1318	327	21	1	1	NUM
dti-1318	327	22	(	(	PUNCT
dti-1318	327	23	ini1	ini1	PROPN
dti-1318	327	24	)	)	PUNCT
dti-1318	327	25	.	.	PUNCT
dti-1318	328	1	ini1	ini1	PROPN
dti-1318	328	2	was	be	AUX
dti-1318	328	3	identifi	identifi	PROPN
dti-1318	328	4	ed	ed	NOUN
dti-1318	328	5	in	in	ADP
dti-1318	328	6	a	a	DET
dti-1318	328	7	yeast	yeast	NOUN
dti-1318	328	8	two	two	NUM
dti-1318	328	9	-	-	PUNCT
dti-1318	328	10	hybrid	hybrid	NOUN
dti-1318	328	11	screen	screen	NOUN
dti-1318	328	12	for	for	ADP
dti-1318	328	13	host	host	NOUN
dti-1318	328	14	cell	cell	NOUN
dti-1318	328	15	proteins	protein	NOUN
dti-1318	328	16	interacting	interact	VERB
dti-1318	328	17	with	with	ADP
dti-1318	328	18	hiv-1	hiv-1	PUNCT
dti-1318	328	19	in	in	ADP
dti-1318	328	20	(	(	PUNCT
dti-1318	328	21	yung	yung	NOUN
dti-1318	328	22	et	et	PROPN
dti-1318	328	23	al	al	PROPN
dti-1318	328	24	.	.	PUNCT
dti-1318	329	1	2001;yung	2001;yung	NUM
dti-1318	329	2	et	et	PROPN
dti-1318	329	3	al	al	PROPN
dti-1318	329	4	.	.	PROPN
dti-1318	329	5	2004	2004	NUM
dti-1318	329	6	;	;	PUNCT
dti-1318	329	7	kalpana	kalpana	PROPN
dti-1318	329	8	et	et	PROPN
dti-1318	329	9	al	al	PROPN
dti-1318	329	10	.	.	PROPN
dti-1318	329	11	1994	1994	NUM
dti-1318	329	12	)	)	PUNCT
dti-1318	329	13	.	.	PUNCT
dti-1318	330	1	ini1	ini1	PROPN
dti-1318	330	2	mutants	mutant	NOUN
dti-1318	330	3	that	that	PRON
dti-1318	330	4	abrogate	abrogate	VERB
dti-1318	330	5	interaction	interaction	NOUN
dti-1318	330	6	with	with	ADP
dti-1318	330	7	in	in	ADP
dti-1318	330	8	or	or	CCONJ
dti-1318	330	9	cells	cell	NOUN
dti-1318	330	10	defi	defi	NOUN
dti-1318	330	11	cient	cient	PROPN
dti-1318	330	12	in	in	ADP
dti-1318	330	13	ini1	ini1	PROPN
dti-1318	330	14	exhibit	exhibit	VERB
dti-1318	330	15	a	a	DET
dti-1318	330	16	substantial	substantial	ADJ
dti-1318	330	17	reduction	reduction	NOUN
dti-1318	330	18	in	in	ADP
dti-1318	330	19	viral	viral	ADJ
dti-1318	330	20	production	production	NOUN
dti-1318	330	21	(	(	PUNCT
dti-1318	330	22	yung	yung	NOUN
dti-1318	330	23	et	et	PROPN
dti-1318	330	24	al	al	PROPN
dti-1318	330	25	.	.	PROPN
dti-1318	330	26	2001	2001	NUM
dti-1318	330	27	)	)	PUNCT
dti-1318	330	28	.	.	PUNCT
dti-1318	331	1	ini1	ini1	PROPN
dti-1318	331	2	affects	affect	VERB
dti-1318	331	3	several	several	ADJ
dti-1318	331	4	steps	step	NOUN
dti-1318	331	5	during	during	ADP
dti-1318	331	6	hiv-1	hiv-1	VERB
dti-1318	331	7	replication	replication	NOUN
dti-1318	331	8	(	(	PUNCT
dti-1318	331	9	ariumi	ariumi	NOUN
dti-1318	331	10	et	et	PROPN
dti-1318	331	11	al	al	PROPN
dti-1318	331	12	.	.	PROPN
dti-1318	331	13	2006	2006	NUM
dti-1318	331	14	;	;	PUNCT
dti-1318	331	15	sorin	sorin	PROPN
dti-1318	331	16	et	et	PROPN
dti-1318	331	17	al	al	PROPN
dti-1318	331	18	.	.	PROPN
dti-1318	331	19	2006	2006	NUM
dti-1318	331	20	;	;	PUNCT
dti-1318	331	21	yung	yung	PROPN
dti-1318	331	22	et	et	PROPN
dti-1318	331	23	al	al	PROPN
dti-1318	331	24	.	.	PROPN
dti-1318	331	25	2001	2001	NUM
dti-1318	331	26	)	)	PUNCT
dti-1318	331	27	and	and	CCONJ
dti-1318	331	28	is	be	AUX
dti-1318	331	29	also	also	ADV
dti-1318	331	30	packaged	package	VERB
dti-1318	331	31	into	into	ADP
dti-1318	331	32	hiv-1	hiv-1	PUNCT
dti-1318	331	33	particles	particle	NOUN
dti-1318	331	34	(	(	PUNCT
dti-1318	331	35	kalpana	kalpana	PROPN
dti-1318	331	36	et	et	PROPN
dti-1318	331	37	al	al	PROPN
dti-1318	331	38	.	.	PROPN
dti-1318	331	39	1994	1994	NUM
dti-1318	331	40	)	)	PUNCT
dti-1318	331	41	.	.	PUNCT
dti-1318	332	1	a	a	DET
dti-1318	332	2	110amino	110amino	PROPN
dti-1318	332	3	-	-	PUNCT
dti-1318	332	4	acid	acid	NOUN
dti-1318	332	5	fragment	fragment	NOUN
dti-1318	332	6	of	of	ADP
dti-1318	332	7	ini1	ini1	PROPN
dti-1318	332	8	(	(	PUNCT
dti-1318	332	9	s6	s6	PROPN
dti-1318	332	10	)	)	PUNCT
dti-1318	332	11	with	with	ADP
dti-1318	332	12	a	a	DET
dti-1318	332	13	minimal	minimal	ADJ
dti-1318	332	14	in	in	ADP
dti-1318	332	15	-	-	PUNCT
dti-1318	332	16	interaction	interaction	NOUN
dti-1318	332	17	domain	domain	NOUN
dti-1318	332	18	inhibits	inhibit	VERB
dti-1318	332	19	viral	viral	ADJ
dti-1318	332	20	production	production	NOUN
dti-1318	332	21	(	(	PUNCT
dti-1318	332	22	yung	yung	NOUN
dti-1318	332	23	et	et	PROPN
dti-1318	332	24	al	al	PROPN
dti-1318	332	25	.	.	PROPN
dti-1318	332	26	2001	2001	NUM
dti-1318	332	27	;	;	PUNCT
dti-1318	332	28	yung	yung	PROPN
dti-1318	332	29	et	et	PROPN
dti-1318	332	30	al	al	PROPN
dti-1318	332	31	.	.	PROPN
dti-1318	332	32	2004	2004	NUM
dti-1318	332	33	)	)	PUNCT
dti-1318	332	34	.	.	PUNCT
dti-1318	333	1	the	the	DET
dti-1318	333	2	inhibitory	inhibitory	ADJ
dti-1318	333	3	effect	effect	NOUN
dti-1318	333	4	of	of	ADP
dti-1318	333	5	s6	s6	PROPN
dti-1318	333	6	on	on	ADP
dti-1318	333	7	hiv-1	hiv-1	X
dti-1318	333	8	production	production	NOUN
dti-1318	333	9	is	be	AUX
dti-1318	333	10	mediated	mediate	VERB
dti-1318	333	11	by	by	ADP
dti-1318	333	12	173	173	NUM
dti-1318	333	13	targeting	target	VERB
dti-1318	333	14	the	the	DET
dti-1318	333	15	late	late	ADJ
dti-1318	333	16	stages	stage	NOUN
dti-1318	333	17	of	of	ADP
dti-1318	333	18	hiv-1	hiv-1	X
dti-1318	333	19	replication	replication	NOUN
dti-1318	333	20	drug	drug	NOUN
dti-1318	333	21	target	target	NOUN
dti-1318	333	22	insights	insight	NOUN
dti-1318	333	23	2007	2007	NUM
dti-1318	333	24	:	:	PUNCT
dti-1318	333	25	2	2	NUM
dti-1318	333	26	binding	binding	NOUN
dti-1318	333	27	of	of	ADP
dti-1318	333	28	the	the	DET
dti-1318	333	29	ectopically	ectopically	ADV
dti-1318	333	30	expressed	express	VERB
dti-1318	333	31	s6	s6	PROPN
dti-1318	333	32	to	to	ADP
dti-1318	333	33	the	the	DET
dti-1318	333	34	gag	gag	NOUN
dti-1318	333	35	-	-	PUNCT
dti-1318	333	36	pol	pol	NOUN
dti-1318	333	37	embedded	embed	VERB
dti-1318	333	38	in	in	ADP
dti-1318	333	39	.	.	PUNCT
dti-1318	334	1	furthermore	furthermore	ADV
dti-1318	334	2	,	,	PUNCT
dti-1318	334	3	stable	stable	ADJ
dti-1318	334	4	expression	expression	NOUN
dti-1318	334	5	of	of	ADP
dti-1318	334	6	a	a	DET
dti-1318	334	7	transdominant	transdominant	ADJ
dti-1318	334	8	s6	s6	PROPN
dti-1318	334	9	mutant	mutant	NOUN
dti-1318	334	10	inhibits	inhibit	VERB
dti-1318	334	11	infection	infection	NOUN
dti-1318	334	12	in	in	ADP
dti-1318	334	13	t	t	PROPN
dti-1318	334	14	-	-	PUNCT
dti-1318	334	15	cells	cell	NOUN
dti-1318	334	16	.	.	PUNCT
dti-1318	335	1	s6	s6	PROPN
dti-1318	335	2	represents	represent	VERB
dti-1318	335	3	a	a	DET
dti-1318	335	4	potential	potential	ADJ
dti-1318	335	5	lead	lead	NOUN
dti-1318	335	6	for	for	ADP
dti-1318	335	7	the	the	DET
dti-1318	335	8	development	development	NOUN
dti-1318	335	9	of	of	ADP
dti-1318	335	10	inhibitors	inhibitor	NOUN
dti-1318	335	11	of	of	ADP
dti-1318	335	12	the	the	DET
dti-1318	335	13	late	late	ADJ
dti-1318	335	14	stage	stage	NOUN
dti-1318	335	15	of	of	ADP
dti-1318	335	16	hiv-1	hiv-1	X
dti-1318	335	17	replication	replication	NOUN
dti-1318	335	18	(	(	PUNCT
dti-1318	335	19	yung	yung	NOUN
dti-1318	335	20	et	et	PROPN
dti-1318	335	21	al	al	PROPN
dti-1318	335	22	.	.	PROPN
dti-1318	335	23	2001	2001	NUM
dti-1318	335	24	)	)	PUNCT
dti-1318	335	25	.	.	PUNCT
dti-1318	336	1	proteosome	proteosome	VERB
dti-1318	336	2	inhibitors	inhibitor	NOUN
dti-1318	336	3	intracellular	intracellular	ADJ
dti-1318	336	4	degradation	degradation	NOUN
dti-1318	336	5	of	of	ADP
dti-1318	336	6	misfolded	misfolded	NOUN
dti-1318	336	7	,	,	PUNCT
dti-1318	336	8	damaged	damaged	ADJ
dti-1318	336	9	or	or	CCONJ
dti-1318	336	10	unwanted	unwanted	ADJ
dti-1318	336	11	proteins	protein	NOUN
dti-1318	336	12	is	be	AUX
dti-1318	336	13	mediated	mediate	VERB
dti-1318	336	14	by	by	ADP
dti-1318	336	15	the	the	DET
dti-1318	336	16	proteosome	proteosome	NOUN
dti-1318	336	17	,	,	PUNCT
dti-1318	336	18	which	which	PRON
dti-1318	336	19	is	be	AUX
dti-1318	336	20	a	a	DET
dti-1318	336	21	multisubunit	multisubunit	NOUN
dti-1318	336	22	proteolytic	proteolytic	ADJ
dti-1318	336	23	complex	complex	NOUN
dti-1318	336	24	of	of	ADP
dti-1318	336	25	26s	26	NOUN
dti-1318	336	26	(	(	PUNCT
dti-1318	336	27	schubert	schubert	PROPN
dti-1318	336	28	et	et	PROPN
dti-1318	336	29	al	al	PROPN
dti-1318	336	30	.	.	PROPN
dti-1318	336	31	2000	2000	NUM
dti-1318	336	32	)	)	PUNCT
dti-1318	336	33	.	.	PUNCT
dti-1318	337	1	proteins	protein	NOUN
dti-1318	337	2	are	be	AUX
dti-1318	337	3	tagged	tag	VERB
dti-1318	337	4	for	for	ADP
dti-1318	337	5	proteolytic	proteolytic	ADJ
dti-1318	337	6	destruction	destruction	NOUN
dti-1318	337	7	by	by	ADP
dti-1318	337	8	the	the	DET
dti-1318	337	9	covalent	covalent	ADJ
dti-1318	337	10	attachment	attachment	NOUN
dti-1318	337	11	of	of	ADP
dti-1318	337	12	a	a	DET
dti-1318	337	13	chain	chain	NOUN
dti-1318	337	14	of	of	ADP
dti-1318	337	15	ubiquitin	ubiquitin	ADJ
dti-1318	337	16	polypeptides	polypeptide	NOUN
dti-1318	337	17	on	on	ADP
dti-1318	337	18	lysine	lysine	NOUN
dti-1318	337	19	residues	residue	NOUN
dti-1318	337	20	of	of	ADP
dti-1318	337	21	the	the	DET
dti-1318	337	22	protein	protein	NOUN
dti-1318	337	23	(	(	PUNCT
dti-1318	337	24	schubert	schubert	PROPN
dti-1318	337	25	et	et	PROPN
dti-1318	337	26	al	al	PROPN
dti-1318	337	27	.	.	PROPN
dti-1318	337	28	2000	2000	NUM
dti-1318	337	29	)	)	PUNCT
dti-1318	337	30	.	.	PUNCT
dti-1318	338	1	proteosome	proteosome	ADJ
dti-1318	338	2	inhibitors	inhibitor	NOUN
dti-1318	338	3	inhibit	inhibit	VERB
dti-1318	338	4	the	the	DET
dti-1318	338	5	late	late	ADJ
dti-1318	338	6	stages	stage	NOUN
dti-1318	338	7	of	of	ADP
dti-1318	338	8	the	the	DET
dti-1318	338	9	hiv-1	hiv-1	ADJ
dti-1318	338	10	life	life	NOUN
dti-1318	338	11	-	-	PUNCT
dti-1318	338	12	cycle	cycle	NOUN
dti-1318	338	13	by	by	ADP
dti-1318	338	14	interfering	interfere	VERB
dti-1318	338	15	with	with	ADP
dti-1318	338	16	viral	viral	ADJ
dti-1318	338	17	particle	particle	NOUN
dti-1318	338	18	release	release	NOUN
dti-1318	338	19	and	and	CCONJ
dti-1318	338	20	maturation	maturation	NOUN
dti-1318	338	21	(	(	PUNCT
dti-1318	338	22	schubert	schubert	PROPN
dti-1318	338	23	et	et	PROPN
dti-1318	338	24	al	al	PROPN
dti-1318	338	25	.	.	PROPN
dti-1318	338	26	2000	2000	NUM
dti-1318	338	27	)	)	PUNCT
dti-1318	338	28	.	.	PUNCT
dti-1318	339	1	decreased	decrease	VERB
dti-1318	339	2	budding	bud	VERB
dti-1318	339	3	has	have	AUX
dti-1318	339	4	also	also	ADV
dti-1318	339	5	been	be	AUX
dti-1318	339	6	demonstrated	demonstrate	VERB
dti-1318	339	7	for	for	ADP
dti-1318	339	8	retroviruses	retrovirus	NOUN
dti-1318	339	9	expressing	express	VERB
dti-1318	339	10	the	the	DET
dti-1318	339	11	pppyor	pppyor	NOUN
dti-1318	339	12	ptap	ptap	NOUN
dti-1318	339	13	containing	contain	VERB
dti-1318	339	14	late	late	ADJ
dti-1318	339	15	domains	domain	NOUN
dti-1318	339	16	but	but	CCONJ
dti-1318	339	17	not	not	PART
dti-1318	339	18	those	those	PRON
dti-1318	339	19	that	that	PRON
dti-1318	339	20	use	use	VERB
dti-1318	339	21	the	the	DET
dti-1318	339	22	ypdl	ypdl	NOUN
dti-1318	339	23	type	type	NOUN
dti-1318	339	24	late	late	ADJ
dti-1318	339	25	domain	domain	NOUN
dti-1318	339	26	(	(	PUNCT
dti-1318	339	27	schubert	schubert	PROPN
dti-1318	339	28	et	et	PROPN
dti-1318	339	29	al	al	PROPN
dti-1318	339	30	.	.	PROPN
dti-1318	339	31	2000	2000	NUM
dti-1318	339	32	;	;	PUNCT
dti-1318	339	33	ott	ott	PROPN
dti-1318	339	34	et	et	PROPN
dti-1318	339	35	al	al	PROPN
dti-1318	339	36	.	.	PROPN
dti-1318	339	37	2003	2003	NUM
dti-1318	339	38	)	)	PUNCT
dti-1318	339	39	.	.	PUNCT
dti-1318	340	1	the	the	DET
dti-1318	340	2	effect	effect	NOUN
dti-1318	340	3	is	be	AUX
dti-1318	340	4	not	not	PART
dti-1318	340	5	dependent	dependent	ADJ
dti-1318	340	6	on	on	ADP
dti-1318	340	7	the	the	DET
dti-1318	340	8	viral	viral	ADJ
dti-1318	340	9	particle	particle	NOUN
dti-1318	340	10	assembly	assembly	NOUN
dti-1318	340	11	site	site	NOUN
dti-1318	340	12	(	(	PUNCT
dti-1318	340	13	i.e.	i.e.	X
dti-1318	340	14	cytoplasm	cytoplasm	ADJ
dti-1318	340	15	or	or	CCONJ
dti-1318	340	16	plasma	plasma	NOUN
dti-1318	340	17	membrane	membrane	NOUN
dti-1318	340	18	)	)	PUNCT
dti-1318	340	19	or	or	CCONJ
dti-1318	340	20	on	on	ADP
dti-1318	340	21	monoubiquitination	monoubiquitination	NOUN
dti-1318	340	22	of	of	ADP
dti-1318	340	23	gag	gag	NOUN
dti-1318	340	24	(	(	PUNCT
dti-1318	340	25	ott	ott	PROPN
dti-1318	340	26	et	et	PROPN
dti-1318	340	27	al	al	PROPN
dti-1318	340	28	.	.	PROPN
dti-1318	340	29	2003	2003	NUM
dti-1318	340	30	)	)	PUNCT
dti-1318	340	31	.	.	PUNCT
dti-1318	341	1	in	in	ADP
dti-1318	341	2	addition	addition	NOUN
dti-1318	341	3	to	to	ADP
dti-1318	341	4	a	a	DET
dti-1318	341	5	decrease	decrease	NOUN
dti-1318	341	6	in	in	ADP
dti-1318	341	7	viral	viral	ADJ
dti-1318	341	8	particle	particle	NOUN
dti-1318	341	9	release	release	NOUN
dti-1318	341	10	(	(	PUNCT
dti-1318	341	11	4	4	NUM
dti-1318	341	12	-	-	NOUN
dti-1318	341	13	fold	fold	ADJ
dti-1318	341	14	)	)	PUNCT
dti-1318	341	15	,	,	PUNCT
dti-1318	341	16	virions	virion	NOUN
dti-1318	341	17	released	release	VERB
dti-1318	341	18	from	from	ADP
dti-1318	341	19	cells	cell	NOUN
dti-1318	341	20	treated	treat	VERB
dti-1318	341	21	with	with	ADP
dti-1318	341	22	proteosome	proteosome	ADJ
dti-1318	341	23	inhibitors	inhibitor	NOUN
dti-1318	341	24	have	have	VERB
dti-1318	341	25	approximately	approximately	ADV
dti-1318	341	26	a	a	DET
dti-1318	341	27	10	10	NUM
dti-1318	341	28	-	-	ADJ
dti-1318	341	29	fold	fold	ADJ
dti-1318	341	30	decrease	decrease	NOUN
dti-1318	341	31	in	in	ADP
dti-1318	341	32	infectivity	infectivity	NOUN
dti-1318	341	33	(	(	PUNCT
dti-1318	341	34	schubert	schubert	PROPN
dti-1318	341	35	et	et	PROPN
dti-1318	341	36	al	al	PROPN
dti-1318	341	37	.	.	PROPN
dti-1318	341	38	2000	2000	NUM
dti-1318	341	39	)	)	PUNCT
dti-1318	341	40	.	.	PUNCT
dti-1318	342	1	the	the	DET
dti-1318	342	2	impact	impact	NOUN
dti-1318	342	3	of	of	ADP
dti-1318	342	4	proteosome	proteosome	ADJ
dti-1318	342	5	inhibitors	inhibitor	NOUN
dti-1318	342	6	is	be	AUX
dti-1318	342	7	dependent	dependent	ADJ
dti-1318	342	8	on	on	ADP
dti-1318	342	9	an	an	DET
dti-1318	342	10	active	active	ADJ
dti-1318	342	11	hiv-1	hiv-1	X
dti-1318	342	12	pr	pr	NOUN
dti-1318	342	13	and	and	CCONJ
dti-1318	342	14	the	the	DET
dti-1318	342	15	presence	presence	NOUN
dti-1318	342	16	of	of	ADP
dti-1318	342	17	the	the	DET
dti-1318	342	18	p6	p6	ADJ
dti-1318	342	19	late	late	ADJ
dti-1318	342	20	domain	domain	NOUN
dti-1318	342	21	but	but	CCONJ
dti-1318	342	22	is	be	AUX
dti-1318	342	23	independent	independent	ADJ
dti-1318	342	24	of	of	ADP
dti-1318	342	25	vpu	vpu	NOUN
dti-1318	342	26	function	function	NOUN
dti-1318	342	27	.	.	PUNCT
dti-1318	343	1	inhibition	inhibition	NOUN
dti-1318	343	2	of	of	ADP
dti-1318	343	3	hiv-1	hiv-1	X
dti-1318	343	4	maturation	maturation	NOUN
dti-1318	343	5	and	and	CCONJ
dti-1318	343	6	budding	budding	NOUN
dti-1318	343	7	is	be	AUX
dti-1318	343	8	observed	observe	VERB
dti-1318	343	9	with	with	ADP
dti-1318	343	10	reversible	reversible	ADJ
dti-1318	343	11	(	(	PUNCT
dti-1318	343	12	zlll	zlll	ADV
dti-1318	343	13	also	also	ADV
dti-1318	343	14	known	know	VERB
dti-1318	343	15	as	as	ADP
dti-1318	343	16	mg-132	mg-132	PROPN
dti-1318	343	17	)	)	PUNCT
dti-1318	343	18	and	and	CCONJ
dti-1318	343	19	irreversible	irreversible	ADJ
dti-1318	343	20	(	(	PUNCT
dti-1318	343	21	lactocystin	lactocystin	NOUN
dti-1318	343	22	)	)	PUNCT
dti-1318	343	23	proteosome	proteosome	ADJ
dti-1318	343	24	inhibitors	inhibitor	NOUN
dti-1318	343	25	(	(	PUNCT
dti-1318	343	26	schubert	schubert	PROPN
dti-1318	343	27	et	et	PROPN
dti-1318	343	28	al	al	PROPN
dti-1318	343	29	.	.	PROPN
dti-1318	343	30	2000	2000	NUM
dti-1318	343	31	)	)	PUNCT
dti-1318	343	32	.	.	PUNCT
dti-1318	344	1	proteosome	proteosome	ADJ
dti-1318	344	2	inhibitors	inhibitor	NOUN
dti-1318	344	3	also	also	ADV
dti-1318	344	4	interfere	interfere	VERB
dti-1318	344	5	with	with	ADP
dti-1318	344	6	the	the	DET
dti-1318	344	7	activity	activity	NOUN
dti-1318	344	8	of	of	ADP
dti-1318	344	9	the	the	DET
dti-1318	344	10	hiv-1	hiv-1	X
dti-1318	344	11	viral	viral	ADJ
dti-1318	344	12	infectivity	infectivity	NOUN
dti-1318	344	13	factor	factor	NOUN
dti-1318	344	14	(	(	PUNCT
dti-1318	344	15	vif	vif	NOUN
dti-1318	344	16	)	)	PUNCT
dti-1318	344	17	on	on	ADP
dti-1318	344	18	the	the	DET
dti-1318	344	19	antiviral	antiviral	ADJ
dti-1318	344	20	function	function	NOUN
dti-1318	344	21	of	of	ADP
dti-1318	344	22	apolipoprotein	apolipoprotein	ADJ
dti-1318	344	23	b	b	PROPN
dti-1318	344	24	mrnaediting	mrnaedite	VERB
dti-1318	344	25	enzyme	enzyme	NOUN
dti-1318	344	26	catalytic	catalytic	ADJ
dti-1318	344	27	polypeptide	polypeptide	ADJ
dti-1318	344	28	-	-	PUNCT
dti-1318	344	29	like	like	ADJ
dti-1318	344	30	3	3	NUM
dti-1318	344	31	g	g	NOUN
dti-1318	344	32	(	(	PUNCT
dti-1318	344	33	apobec3	apobec3	ADP
dti-1318	344	34	g	g	NOUN
dti-1318	344	35	)	)	PUNCT
dti-1318	344	36	in	in	ADP
dti-1318	344	37	virus	virus	NOUN
dti-1318	344	38	producing	produce	VERB
dti-1318	344	39	cells	cell	NOUN
dti-1318	344	40	(	(	PUNCT
dti-1318	344	41	stopak	stopak	NOUN
dti-1318	344	42	et	et	PROPN
dti-1318	344	43	al	al	PROPN
dti-1318	344	44	.	.	PROPN
dti-1318	344	45	2003	2003	NUM
dti-1318	344	46	;	;	PUNCT
dti-1318	344	47	sheehy	sheehy	PROPN
dti-1318	344	48	et	et	PROPN
dti-1318	344	49	al	al	PROPN
dti-1318	344	50	.	.	PROPN
dti-1318	344	51	2003	2003	NUM
dti-1318	344	52	;	;	PUNCT
dti-1318	344	53	mehle	mehle	VERB
dti-1318	344	54	et	et	PROPN
dti-1318	344	55	al	al	PROPN
dti-1318	344	56	.	.	PROPN
dti-1318	344	57	2004	2004	NUM
dti-1318	344	58	;	;	PUNCT
dti-1318	344	59	yu	yu	PROPN
dti-1318	344	60	et	et	PROPN
dti-1318	344	61	al	al	PROPN
dti-1318	344	62	.	.	PROPN
dti-1318	344	63	2003	2003	NUM
dti-1318	344	64	)	)	PUNCT
dti-1318	344	65	.	.	PUNCT
dti-1318	345	1	wild	wild	ADJ
dti-1318	345	2	-	-	PUNCT
dti-1318	345	3	type	type	NOUN
dti-1318	345	4	viruses	virus	NOUN
dti-1318	345	5	expressing	express	VERB
dti-1318	345	6	vif	vif	NOUN
dti-1318	345	7	are	be	AUX
dti-1318	345	8	able	able	ADJ
dti-1318	345	9	to	to	PART
dti-1318	345	10	prevent	prevent	VERB
dti-1318	345	11	incorporation	incorporation	NOUN
dti-1318	345	12	of	of	ADP
dti-1318	345	13	apobec3	apobec3	ADJ
dti-1318	345	14	g	g	NOUN
dti-1318	345	15	into	into	ADP
dti-1318	345	16	the	the	DET
dti-1318	345	17	virion	virion	NOUN
dti-1318	345	18	by	by	ADP
dti-1318	345	19	promoting	promote	VERB
dti-1318	345	20	its	its	PRON
dti-1318	345	21	degradation	degradation	NOUN
dti-1318	345	22	in	in	ADP
dti-1318	345	23	the	the	DET
dti-1318	345	24	cytoplasm	cytoplasm	NOUN
dti-1318	345	25	of	of	ADP
dti-1318	345	26	the	the	DET
dti-1318	345	27	producer	producer	NOUN
dti-1318	345	28	cell	cell	NOUN
dti-1318	345	29	.	.	PUNCT
dti-1318	346	1	inhibition	inhibition	NOUN
dti-1318	346	2	of	of	ADP
dti-1318	346	3	apobec3	apobec3	ADP
dti-1318	346	4	g	g	NOUN
dti-1318	346	5	incorporation	incorporation	NOUN
dti-1318	346	6	in	in	ADP
dti-1318	346	7	the	the	DET
dti-1318	346	8	virus	virus	NOUN
dti-1318	346	9	prevents	prevent	VERB
dti-1318	346	10	hypermutation	hypermutation	NOUN
dti-1318	346	11	in	in	ADP
dti-1318	346	12	newly	newly	ADV
dti-1318	346	13	synthesized	synthesize	VERB
dti-1318	346	14	viral	viral	ADJ
dti-1318	346	15	dna	dna	NOUN
dti-1318	346	16	following	follow	VERB
dti-1318	346	17	infection	infection	NOUN
dti-1318	346	18	of	of	ADP
dti-1318	346	19	target	target	NOUN
dti-1318	346	20	cells	cell	NOUN
dti-1318	346	21	due	due	ADJ
dti-1318	346	22	to	to	ADP
dti-1318	346	23	c	c	PROPN
dti-1318	346	24	to	to	ADP
dti-1318	346	25	u	u	PROPN
dti-1318	346	26	modifi	modifi	NOUN
dti-1318	346	27	cations	cation	NOUN
dti-1318	346	28	during	during	ADP
dti-1318	346	29	minus	minus	CCONJ
dti-1318	346	30	stand	stand	VERB
dti-1318	346	31	dna	dna	PROPN
dti-1318	346	32	synthesis	synthesis	NOUN
dti-1318	346	33	mediated	mediate	VERB
dti-1318	346	34	by	by	ADP
dti-1318	346	35	apobec3	apobec3	PROPN
dti-1318	346	36	g.	g.	PROPN
dti-1318	346	37	proteosome	proteosome	PROPN
dti-1318	346	38	inhibitors	inhibitor	NOUN
dti-1318	346	39	interfere	interfere	VERB
dti-1318	346	40	with	with	ADP
dti-1318	346	41	vif	vif	PROPN
dti-1318	346	42	dependent	dependent	ADJ
dti-1318	346	43	degradation	degradation	NOUN
dti-1318	346	44	of	of	ADP
dti-1318	346	45	apobec3	apobec3	ADP
dti-1318	346	46	g	g	NOUN
dti-1318	346	47	suggesting	suggest	VERB
dti-1318	346	48	that	that	SCONJ
dti-1318	346	49	these	these	DET
dti-1318	346	50	inhibitors	inhibitor	NOUN
dti-1318	346	51	can	can	AUX
dti-1318	346	52	impede	impede	VERB
dti-1318	346	53	the	the	DET
dti-1318	346	54	mechanisms	mechanism	NOUN
dti-1318	346	55	used	use	VERB
dti-1318	346	56	by	by	ADP
dti-1318	346	57	the	the	DET
dti-1318	346	58	virus	virus	NOUN
dti-1318	346	59	to	to	PART
dti-1318	346	60	evade	evade	VERB
dti-1318	346	61	the	the	DET
dti-1318	346	62	innate	innate	ADJ
dti-1318	346	63	defences	defence	NOUN
dti-1318	346	64	of	of	ADP
dti-1318	346	65	the	the	DET
dti-1318	346	66	host	host	NOUN
dti-1318	346	67	cell	cell	NOUN
dti-1318	346	68	(	(	PUNCT
dti-1318	346	69	stopak	stopak	NOUN
dti-1318	346	70	et	et	PROPN
dti-1318	346	71	al	al	PROPN
dti-1318	346	72	.	.	PROPN
dti-1318	346	73	2003	2003	NUM
dti-1318	346	74	;	;	PUNCT
dti-1318	346	75	sheehy	sheehy	PROPN
dti-1318	346	76	et	et	PROPN
dti-1318	346	77	al	al	PROPN
dti-1318	346	78	.	.	PROPN
dti-1318	346	79	2003	2003	NUM
dti-1318	346	80	;	;	PUNCT
dti-1318	346	81	mehle	mehle	VERB
dti-1318	346	82	et	et	PROPN
dti-1318	346	83	al	al	PROPN
dti-1318	346	84	.	.	PROPN
dti-1318	346	85	2004	2004	NUM
dti-1318	346	86	;	;	PUNCT
dti-1318	346	87	yu	yu	PROPN
dti-1318	346	88	et	et	PROPN
dti-1318	346	89	al	al	PROPN
dti-1318	346	90	.	.	PROPN
dti-1318	346	91	2003	2003	NUM
dti-1318	346	92	)	)	PUNCT
dti-1318	346	93	.	.	PUNCT
dti-1318	347	1	targeting	target	VERB
dti-1318	347	2	an	an	DET
dti-1318	347	3	essential	essential	ADJ
dti-1318	347	4	cellular	cellular	ADJ
dti-1318	347	5	process	process	NOUN
dti-1318	347	6	like	like	ADP
dti-1318	347	7	the	the	DET
dti-1318	347	8	proteosome	proteosome	NOUN
dti-1318	347	9	is	be	AUX
dti-1318	347	10	anticipated	anticipate	VERB
dti-1318	347	11	to	to	PART
dti-1318	347	12	be	be	AUX
dti-1318	347	13	cytotoxic	cytotoxic	ADJ
dti-1318	347	14	and	and	CCONJ
dti-1318	347	15	not	not	PART
dti-1318	347	16	well	well	ADV
dti-1318	347	17	tolerated	tolerate	VERB
dti-1318	347	18	in	in	ADP
dti-1318	347	19	vivo	vivo	NOUN
dti-1318	347	20	.	.	PUNCT
dti-1318	348	1	nevertheless	nevertheless	ADV
dti-1318	348	2	,	,	PUNCT
dti-1318	348	3	the	the	DET
dti-1318	348	4	highly	highly	ADV
dti-1318	348	5	specifi	specifi	X
dti-1318	348	6	c	c	PROPN
dti-1318	348	7	proteosome	proteosome	PROPN
dti-1318	348	8	inhibitor	inhibitor	NOUN
dti-1318	348	9	epoxomicin	epoxomicin	NOUN
dti-1318	348	10	,	,	PUNCT
dti-1318	348	11	which	which	PRON
dti-1318	348	12	also	also	ADV
dti-1318	348	13	inhibits	inhibit	VERB
dti-1318	348	14	hiv-1	hiv-1	ADJ
dti-1318	348	15	maturation	maturation	NOUN
dti-1318	348	16	,	,	PUNCT
dti-1318	348	17	is	be	AUX
dti-1318	348	18	well	well	ADV
dti-1318	348	19	tolerated	tolerate	VERB
dti-1318	348	20	in	in	ADP
dti-1318	348	21	mice	mouse	NOUN
dti-1318	348	22	(	(	PUNCT
dti-1318	348	23	meng	meng	PROPN
dti-1318	348	24	et	et	PROPN
dti-1318	348	25	al	al	PROPN
dti-1318	348	26	.	.	PROPN
dti-1318	348	27	1999	1999	NUM
dti-1318	348	28	)	)	PUNCT
dti-1318	348	29	.	.	PUNCT
dti-1318	349	1	the	the	DET
dti-1318	349	2	proteosome	proteosome	ADJ
dti-1318	349	3	inhibitor	inhibitor	NOUN
dti-1318	349	4	,	,	PUNCT
dti-1318	349	5	ps-341	ps-341	PROPN
dti-1318	349	6	,	,	PUNCT
dti-1318	349	7	is	be	AUX
dti-1318	349	8	approved	approve	VERB
dti-1318	349	9	as	as	ADP
dti-1318	349	10	a	a	DET
dti-1318	349	11	last	last	ADJ
dti-1318	349	12	resort	resort	NOUN
dti-1318	349	13	treatment	treatment	NOUN
dti-1318	349	14	of	of	ADP
dti-1318	349	15	multiple	multiple	ADJ
dti-1318	349	16	myelomas	myeloma	NOUN
dti-1318	349	17	and	and	CCONJ
dti-1318	349	18	is	be	AUX
dti-1318	349	19	associated	associate	VERB
dti-1318	349	20	with	with	ADP
dti-1318	349	21	adverse	adverse	ADJ
dti-1318	349	22	effects	effect	NOUN
dti-1318	349	23	(	(	PUNCT
dti-1318	349	24	kane	kane	PROPN
dti-1318	349	25	et	et	PROPN
dti-1318	349	26	al	al	PROPN
dti-1318	349	27	.	.	PROPN
dti-1318	349	28	2006	2006	NUM
dti-1318	349	29	)	)	PUNCT
dti-1318	349	30	.	.	PUNCT
dti-1318	350	1	the	the	DET
dti-1318	350	2	use	use	NOUN
dti-1318	350	3	of	of	ADP
dti-1318	350	4	proteosome	proteosome	ADJ
dti-1318	350	5	inhibitors	inhibitor	NOUN
dti-1318	350	6	in	in	ADP
dti-1318	350	7	hiv-1	hiv-1	PUNCT
dti-1318	350	8	infected	infect	VERB
dti-1318	350	9	individuals	individual	NOUN
dti-1318	350	10	needs	need	VERB
dti-1318	350	11	to	to	PART
dti-1318	350	12	be	be	AUX
dti-1318	350	13	considered	consider	VERB
dti-1318	350	14	in	in	ADP
dti-1318	350	15	the	the	DET
dti-1318	350	16	context	context	NOUN
dti-1318	350	17	of	of	ADP
dti-1318	350	18	the	the	DET
dti-1318	350	19	potential	potential	ADJ
dti-1318	350	20	risk	risk	NOUN
dti-1318	350	21	benefi	benefi	PROPN
dti-1318	350	22	t	t	PROPN
dti-1318	350	23	and	and	CCONJ
dti-1318	350	24	the	the	DET
dti-1318	350	25	net	net	ADJ
dti-1318	350	26	effect	effect	NOUN
dti-1318	350	27	on	on	ADP
dti-1318	350	28	inhibition	inhibition	NOUN
dti-1318	350	29	of	of	ADP
dti-1318	350	30	hiv-1	hiv-1	X
dti-1318	350	31	replication	replication	NOUN
dti-1318	350	32	as	as	ADP
dti-1318	350	33	proteosome	proteosome	ADJ
dti-1318	350	34	inhibitors	inhibitor	NOUN
dti-1318	350	35	also	also	ADV
dti-1318	350	36	enhance	enhance	VERB
dti-1318	350	37	the	the	DET
dti-1318	350	38	early	early	ADJ
dti-1318	350	39	step	step	NOUN
dti-1318	350	40	of	of	ADP
dti-1318	350	41	the	the	DET
dti-1318	350	42	virus	virus	NOUN
dti-1318	350	43	life	life	NOUN
dti-1318	350	44	-	-	PUNCT
dti-1318	350	45	cycle	cycle	NOUN
dti-1318	350	46	by	by	ADP
dti-1318	350	47	preventing	prevent	VERB
dti-1318	350	48	degradation	degradation	NOUN
dti-1318	350	49	of	of	ADP
dti-1318	350	50	the	the	DET
dti-1318	350	51	reverse	reverse	ADJ
dti-1318	350	52	transcription	transcription	NOUN
dti-1318	350	53	complex	complex	NOUN
dti-1318	350	54	mediated	mediate	VERB
dti-1318	350	55	by	by	ADP
dti-1318	350	56	trim5α	trim5α	PROPN
dti-1318	350	57	(	(	PUNCT
dti-1318	350	58	schwartz	schwartz	PROPN
dti-1318	350	59	et	et	PROPN
dti-1318	350	60	al	al	PROPN
dti-1318	350	61	.	.	PROPN
dti-1318	350	62	1998	1998	NUM
dti-1318	350	63	;	;	PUNCT
dti-1318	350	64	wu	wu	PROPN
dti-1318	350	65	et	et	PROPN
dti-1318	350	66	al	al	PROPN
dti-1318	350	67	.	.	PROPN
dti-1318	350	68	2006	2006	NUM
dti-1318	350	69	;	;	PUNCT
dti-1318	350	70	wei	wei	PROPN
dti-1318	350	71	et	et	PROPN
dti-1318	350	72	al	al	PROPN
dti-1318	350	73	.	.	PROPN
dti-1318	350	74	2005	2005	NUM
dti-1318	350	75	)	)	PUNCT
dti-1318	350	76	.	.	PUNCT
dti-1318	351	1	targeting	target	VERB
dti-1318	351	2	hiv-1	hiv-1	X
dti-1318	351	3	egress	egress	NOUN
dti-1318	351	4	mediated	mediate	VERB
dti-1318	351	5	by	by	ADP
dti-1318	351	6	vpu	vpu	ADP
dti-1318	351	7	the	the	DET
dti-1318	351	8	hiv-1	hiv-1	X
dti-1318	351	9	accessory	accessory	ADJ
dti-1318	351	10	protein	protein	NOUN
dti-1318	351	11	,	,	PUNCT
dti-1318	351	12	vpu	vpu	NOUN
dti-1318	351	13	is	be	AUX
dti-1318	351	14	a	a	DET
dti-1318	351	15	16	16	NUM
dti-1318	351	16	kda	kda	NOUN
dti-1318	351	17	type	type	NOUN
dti-1318	351	18	1	1	NUM
dti-1318	351	19	integral	integral	ADJ
dti-1318	351	20	membrane	membrane	NOUN
dti-1318	351	21	protein	protein	NOUN
dti-1318	351	22	that	that	PRON
dti-1318	351	23	is	be	AUX
dti-1318	351	24	indispensable	indispensable	ADJ
dti-1318	351	25	for	for	ADP
dti-1318	351	26	viral	viral	ADJ
dti-1318	351	27	pathogenesis	pathogenesis	NOUN
dti-1318	351	28	(	(	PUNCT
dti-1318	351	29	li	li	PROPN
dti-1318	351	30	et	et	PROPN
dti-1318	351	31	al	al	PROPN
dti-1318	351	32	.	.	PROPN
dti-1318	351	33	2005	2005	NUM
dti-1318	351	34	)	)	PUNCT
dti-1318	351	35	.	.	PUNCT
dti-1318	352	1	vpu	vpu	PROPN
dti-1318	352	2	plays	play	VERB
dti-1318	352	3	two	two	NUM
dti-1318	352	4	distinctive	distinctive	ADJ
dti-1318	352	5	roles	role	NOUN
dti-1318	352	6	in	in	ADP
dti-1318	352	7	the	the	DET
dti-1318	352	8	viral	viral	ADJ
dti-1318	352	9	life	life	NOUN
dti-1318	352	10	-	-	PUNCT
dti-1318	352	11	cycle	cycle	NOUN
dti-1318	352	12	that	that	PRON
dti-1318	352	13	include	include	VERB
dti-1318	352	14	down	down	ADP
dti-1318	352	15	regulating	regulate	VERB
dti-1318	352	16	host	host	NOUN
dti-1318	352	17	cell	cell	NOUN
dti-1318	352	18	cd4	cd4	NOUN
dti-1318	352	19	receptors	receptor	NOUN
dti-1318	352	20	(	(	PUNCT
dti-1318	352	21	willey	willey	PROPN
dti-1318	352	22	et	et	PROPN
dti-1318	352	23	al	al	PROPN
dti-1318	352	24	.	.	PROPN
dti-1318	352	25	1992	1992	NUM
dti-1318	352	26	)	)	PUNCT
dti-1318	352	27	and	and	CCONJ
dti-1318	352	28	enhancing	enhance	VERB
dti-1318	352	29	viral	viral	ADJ
dti-1318	352	30	particle	particle	NOUN
dti-1318	352	31	release	release	NOUN
dti-1318	352	32	from	from	ADP
dti-1318	352	33	the	the	DET
dti-1318	352	34	cell	cell	NOUN
dti-1318	352	35	surface	surface	NOUN
dti-1318	352	36	,	,	PUNCT
dti-1318	352	37	the	the	DET
dti-1318	352	38	latter	latter	ADJ
dti-1318	352	39	associated	associate	VERB
dti-1318	352	40	with	with	ADP
dti-1318	352	41	its	its	PRON
dti-1318	352	42	ion	ion	NOUN
dti-1318	352	43	channel	channel	NOUN
dti-1318	352	44	forming	form	VERB
dti-1318	352	45	properties	property	NOUN
dti-1318	352	46	(	(	PUNCT
dti-1318	352	47	schubert	schubert	PROPN
dti-1318	352	48	et	et	PROPN
dti-1318	352	49	al	al	PROPN
dti-1318	352	50	.	.	PROPN
dti-1318	352	51	1996a	1996a	NUM
dti-1318	352	52	)	)	PUNCT
dti-1318	352	53	.	.	PUNCT
dti-1318	353	1	vpu	vpu	NOUN
dti-1318	353	2	is	be	AUX
dti-1318	353	3	unique	unique	ADJ
dti-1318	353	4	to	to	ADP
dti-1318	353	5	hiv-1	hiv-1	X
dti-1318	353	6	/	/	SYM
dti-1318	353	7	sivcpz	sivcpz	NOUN
dti-1318	353	8	viruses	virus	NOUN
dti-1318	353	9	(	(	PUNCT
dti-1318	353	10	binette	binette	NOUN
dti-1318	353	11	and	and	CCONJ
dti-1318	353	12	cohen	cohen	PROPN
dti-1318	353	13	,	,	PUNCT
dti-1318	353	14	2004	2004	NUM
dti-1318	353	15	)	)	PUNCT
dti-1318	353	16	.	.	PUNCT
dti-1318	354	1	interestingly	interestingly	ADV
dti-1318	354	2	the	the	DET
dti-1318	354	3	two	two	NUM
dti-1318	354	4	closely	closely	ADV
dti-1318	354	5	related	relate	VERB
dti-1318	354	6	retroviruses	retrovirus	NOUN
dti-1318	354	7	hiv-2	hiv-2	NUM
dti-1318	354	8	and	and	CCONJ
dti-1318	354	9	siv	siv	PROPN
dti-1318	354	10	,	,	PUNCT
dti-1318	354	11	which	which	PRON
dti-1318	354	12	lack	lack	VERB
dti-1318	354	13	vpu	vpu	NOUN
dti-1318	354	14	,	,	PUNCT
dti-1318	354	15	are	be	AUX
dti-1318	354	16	less	less	ADV
dti-1318	354	17	pathogenic	pathogenic	ADJ
dti-1318	354	18	(	(	PUNCT
dti-1318	354	19	bour	bour	NOUN
dti-1318	354	20	and	and	CCONJ
dti-1318	354	21	strebel	strebel	NOUN
dti-1318	354	22	,	,	PUNCT
dti-1318	354	23	2003	2003	NUM
dti-1318	354	24	)	)	PUNCT
dti-1318	354	25	.	.	PUNCT
dti-1318	355	1	the	the	DET
dti-1318	355	2	role	role	NOUN
dti-1318	355	3	of	of	ADP
dti-1318	355	4	vpu	vpu	NOUN
dti-1318	355	5	in	in	ADP
dti-1318	355	6	the	the	DET
dti-1318	355	7	viral	viral	ADJ
dti-1318	355	8	budding	budding	NOUN
dti-1318	355	9	process	process	NOUN
dti-1318	355	10	is	be	AUX
dti-1318	355	11	coupled	couple	VERB
dti-1318	355	12	to	to	ADP
dti-1318	355	13	its	its	PRON
dti-1318	355	14	ion	ion	NOUN
dti-1318	355	15	channel	channel	NOUN
dti-1318	355	16	forming	form	VERB
dti-1318	355	17	properties	property	NOUN
dti-1318	355	18	,	,	PUNCT
dti-1318	355	19	which	which	PRON
dti-1318	355	20	is	be	AUX
dti-1318	355	21	predicted	predict	VERB
dti-1318	355	22	to	to	PART
dti-1318	355	23	be	be	AUX
dti-1318	355	24	a	a	DET
dti-1318	355	25	pentameric	pentameric	ADJ
dti-1318	355	26	structure	structure	NOUN
dti-1318	355	27	composed	compose	VERB
dti-1318	355	28	of	of	ADP
dti-1318	355	29	fi	fi	NOUN
dti-1318	355	30	ve	ve	NOUN
dti-1318	355	31	transmembrane	transmembrane	NOUN
dti-1318	355	32	domains	domain	NOUN
dti-1318	355	33	(	(	PUNCT
dti-1318	355	34	grice	grice	PROPN
dti-1318	355	35	et	et	PROPN
dti-1318	355	36	al	al	PROPN
dti-1318	355	37	.	.	PROPN
dti-1318	355	38	1997	1997	NUM
dti-1318	355	39	)	)	PUNCT
dti-1318	355	40	.	.	PUNCT
dti-1318	356	1	the	the	DET
dti-1318	356	2	vpu	vpu	PROPN
dti-1318	356	3	ion	ion	NOUN
dti-1318	356	4	channel	channel	NOUN
dti-1318	356	5	is	be	AUX
dti-1318	356	6	thought	think	VERB
dti-1318	356	7	to	to	PART
dti-1318	356	8	function	function	VERB
dti-1318	356	9	by	by	ADP
dti-1318	356	10	altering	alter	VERB
dti-1318	356	11	the	the	DET
dti-1318	356	12	electric	electric	ADJ
dti-1318	356	13	potential	potential	NOUN
dti-1318	356	14	at	at	ADP
dti-1318	356	15	the	the	DET
dti-1318	356	16	plasma	plasma	NOUN
dti-1318	356	17	membrane	membrane	NOUN
dti-1318	356	18	or	or	CCONJ
dti-1318	356	19	alternatively	alternatively	ADV
dti-1318	356	20	by	by	ADP
dti-1318	356	21	overcoming	overcome	VERB
dti-1318	356	22	host	host	NOUN
dti-1318	356	23	restriction	restriction	NOUN
dti-1318	356	24	factors	factor	NOUN
dti-1318	356	25	for	for	ADP
dti-1318	356	26	viral	viral	ADJ
dti-1318	356	27	release	release	NOUN
dti-1318	356	28	(	(	PUNCT
dti-1318	356	29	neil	neil	PROPN
dti-1318	356	30	et	et	PROPN
dti-1318	356	31	al	al	PROPN
dti-1318	356	32	.	.	PROPN
dti-1318	356	33	2006	2006	NUM
dti-1318	356	34	)	)	PUNCT
dti-1318	356	35	.	.	PUNCT
dti-1318	357	1	the	the	DET
dti-1318	357	2	hiv-1	hiv-1	NUM
dti-1318	357	3	vpu	vpu	NOUN
dti-1318	357	4	is	be	AUX
dti-1318	357	5	a	a	DET
dti-1318	357	6	member	member	NOUN
dti-1318	357	7	of	of	ADP
dti-1318	357	8	viral	viral	ADJ
dti-1318	357	9	ion	ion	NOUN
dti-1318	357	10	channel	channel	NOUN
dti-1318	357	11	proteins	protein	NOUN
dti-1318	357	12	called	call	VERB
dti-1318	357	13	viroporins	viroporin	NOUN
dti-1318	357	14	and	and	CCONJ
dti-1318	357	15	is	be	AUX
dti-1318	357	16	structurally	structurally	ADV
dti-1318	357	17	similar	similar	ADJ
dti-1318	357	18	to	to	ADP
dti-1318	357	19	the	the	DET
dti-1318	357	20	m2	m2	PROPN
dti-1318	357	21	ion	ion	NOUN
dti-1318	357	22	channel	channel	NOUN
dti-1318	357	23	protein	protein	NOUN
dti-1318	357	24	of	of	ADP
dti-1318	357	25	infl	infl	PROPN
dti-1318	357	26	uenza	uenza	PROPN
dti-1318	357	27	(	(	PUNCT
dti-1318	357	28	gonzalez	gonzalez	PROPN
dti-1318	357	29	and	and	CCONJ
dti-1318	357	30	carrasco	carrasco	PROPN
dti-1318	357	31	,	,	PUNCT
dti-1318	357	32	2003	2003	NUM
dti-1318	357	33	;	;	PUNCT
dti-1318	357	34	hout	hout	PROPN
dti-1318	357	35	et	et	PROPN
dti-1318	357	36	al	al	PROPN
dti-1318	357	37	.	.	PROPN
dti-1318	357	38	2006	2006	NUM
dti-1318	357	39	)	)	PUNCT
dti-1318	357	40	.	.	PUNCT
dti-1318	358	1	an	an	DET
dti-1318	358	2	interesting	interesting	ADJ
dti-1318	358	3	feature	feature	NOUN
dti-1318	358	4	of	of	ADP
dti-1318	358	5	vpu	vpu	NOUN
dti-1318	358	6	is	be	AUX
dti-1318	358	7	its	its	PRON
dti-1318	358	8	role	role	NOUN
dti-1318	358	9	in	in	ADP
dti-1318	358	10	174	174	NUM
dti-1318	358	11	wapling	waple	VERB
dti-1318	358	12	et	et	PROPN
dti-1318	358	13	al	al	PROPN
dti-1318	358	14	drug	drug	PROPN
dti-1318	358	15	target	target	NOUN
dti-1318	358	16	insights	insight	NOUN
dti-1318	358	17	2007	2007	NUM
dti-1318	358	18	:	:	PUNCT
dti-1318	358	19	2	2	NUM
dti-1318	358	20	viral	viral	ADJ
dti-1318	358	21	particle	particle	NOUN
dti-1318	358	22	release	release	NOUN
dti-1318	358	23	from	from	ADP
dti-1318	358	24	nondividing	nondivide	VERB
dti-1318	358	25	cells	cell	NOUN
dti-1318	358	26	such	such	ADJ
dti-1318	358	27	as	as	ADP
dti-1318	358	28	macrophages	macrophage	NOUN
dti-1318	358	29	(	(	PUNCT
dti-1318	358	30	deora	deora	PROPN
dti-1318	358	31	and	and	CCONJ
dti-1318	358	32	ratner	ratner	PROPN
dti-1318	358	33	,	,	PUNCT
dti-1318	358	34	2001	2001	NUM
dti-1318	358	35	)	)	PUNCT
dti-1318	358	36	.	.	PUNCT
dti-1318	359	1	in	in	ADP
dti-1318	359	2	this	this	DET
dti-1318	359	3	regard	regard	NOUN
dti-1318	359	4	the	the	DET
dti-1318	359	5	rate	rate	NOUN
dti-1318	359	6	of	of	ADP
dti-1318	359	7	host	host	NOUN
dti-1318	359	8	cell	cell	NOUN
dti-1318	359	9	proliferation	proliferation	NOUN
dti-1318	359	10	is	be	AUX
dti-1318	359	11	a	a	DET
dti-1318	359	12	determining	determine	VERB
dti-1318	359	13	factor	factor	NOUN
dti-1318	359	14	for	for	ADP
dti-1318	359	15	vpu	vpu	NOUN
dti-1318	359	16	mediated	mediate	VERB
dti-1318	359	17	viral	viral	ADJ
dti-1318	359	18	particle	particle	NOUN
dti-1318	359	19	release	release	NOUN
dti-1318	359	20	(	(	PUNCT
dti-1318	359	21	deora	deora	PROPN
dti-1318	359	22	and	and	CCONJ
dti-1318	359	23	ratner	ratner	PROPN
dti-1318	359	24	,	,	PUNCT
dti-1318	359	25	2001	2001	NUM
dti-1318	359	26	)	)	PUNCT
dti-1318	359	27	.	.	PUNCT
dti-1318	360	1	analogues	analogue	NOUN
dti-1318	360	2	of	of	ADP
dti-1318	360	3	amiloride	amiloride	NOUN
dti-1318	360	4	(	(	PUNCT
dti-1318	360	5	a	a	DET
dti-1318	360	6	sodium	sodium	NOUN
dti-1318	360	7	channel	channel	NOUN
dti-1318	360	8	blocker	blocker	NOUN
dti-1318	360	9	)	)	PUNCT
dti-1318	360	10	inhibit	inhibit	NOUN
dti-1318	360	11	vpu	vpu	ADP
dti-1318	360	12	ion	ion	NOUN
dti-1318	360	13	channel	channel	NOUN
dti-1318	360	14	activity	activity	NOUN
dti-1318	360	15	.	.	PUNCT
dti-1318	361	1	the	the	DET
dti-1318	361	2	amiloride	amiloride	ADJ
dti-1318	361	3	analogues	analogue	NOUN
dti-1318	361	4	,	,	PUNCT
dti-1318	361	5	5-(n	5-(n	NUM
dti-1318	361	6	,	,	PUNCT
dti-1318	361	7	n	n	CCONJ
dti-1318	361	8	-	-	PUNCT
dti-1318	361	9	hexamethylene	hexamethylene	NOUN
dti-1318	361	10	)	)	PUNCT
dti-1318	361	11	amiloride	amiloride	NOUN
dti-1318	361	12	(	(	PUNCT
dti-1318	361	13	hma	hma	NOUN
dti-1318	361	14	)	)	PUNCT
dti-1318	361	15	and	and	CCONJ
dti-1318	361	16	5-(n	5-(n	NUM
dti-1318	361	17	,	,	PUNCT
dti-1318	361	18	n	n	CCONJ
dti-1318	361	19	-	-	PUNCT
dti-1318	361	20	dimethyl)amiloride	dimethyl)amiloride	NOUN
dti-1318	361	21	(	(	PUNCT
dti-1318	361	22	dma	dma	NOUN
dti-1318	361	23	)	)	PUNCT
dti-1318	361	24	inhibit	inhibit	NOUN
dti-1318	361	25	vpu	vpu	NOUN
dti-1318	361	26	mediated	mediate	VERB
dti-1318	361	27	virus	virus	NOUN
dti-1318	361	28	budding	budding	NOUN
dti-1318	361	29	and	and	CCONJ
dti-1318	361	30	viral	viral	ADJ
dti-1318	361	31	replication	replication	NOUN
dti-1318	361	32	in	in	ADP
dti-1318	361	33	macrophages	macrophage	NOUN
dti-1318	361	34	(	(	PUNCT
dti-1318	361	35	ewart	ewart	NOUN
dti-1318	361	36	et	et	PROPN
dti-1318	361	37	al	al	PROPN
dti-1318	361	38	.	.	PROPN
dti-1318	361	39	2002	2002	NUM
dti-1318	361	40	;	;	PUNCT
dti-1318	361	41	ewart	ewart	PROPN
dti-1318	361	42	et	et	PROPN
dti-1318	361	43	al	al	PROPN
dti-1318	361	44	.	.	PROPN
dti-1318	361	45	2004	2004	NUM
dti-1318	361	46	)	)	PUNCT
dti-1318	361	47	.	.	PUNCT
dti-1318	362	1	the	the	DET
dti-1318	362	2	inhibitory	inhibitory	ADJ
dti-1318	362	3	effects	effect	NOUN
dti-1318	362	4	are	be	AUX
dti-1318	362	5	observed	observe	VERB
dti-1318	362	6	in	in	ADP
dti-1318	362	7	the	the	DET
dti-1318	362	8	absence	absence	NOUN
dti-1318	362	9	of	of	ADP
dti-1318	362	10	cytotoxicity	cytotoxicity	NOUN
dti-1318	362	11	.	.	PUNCT
dti-1318	363	1	both	both	DET
dti-1318	363	2	analogs	analog	NOUN
dti-1318	363	3	exhibit	exhibit	VERB
dti-1318	363	4	strong	strong	ADJ
dti-1318	363	5	inhibition	inhibition	NOUN
dti-1318	363	6	of	of	ADP
dti-1318	363	7	hiv-1	hiv-1	X
dti-1318	363	8	replication	replication	NOUN
dti-1318	363	9	as	as	SCONJ
dti-1318	363	10	measured	measure	VERB
dti-1318	363	11	by	by	ADP
dti-1318	363	12	viral	viral	ADJ
dti-1318	363	13	p24	p24	NOUN
dti-1318	363	14	levels	level	NOUN
dti-1318	363	15	in	in	ADP
dti-1318	363	16	culture	culture	NOUN
dti-1318	363	17	supernatants	supernatant	NOUN
dti-1318	363	18	(	(	PUNCT
dti-1318	363	19	ewart	ewart	NOUN
dti-1318	363	20	et	et	PROPN
dti-1318	363	21	al	al	PROPN
dti-1318	363	22	.	.	PROPN
dti-1318	363	23	2004	2004	NUM
dti-1318	363	24	)	)	PUNCT
dti-1318	363	25	.	.	PUNCT
dti-1318	364	1	hma	hma	NOUN
dti-1318	364	2	at	at	ADP
dti-1318	364	3	4	4	NUM
dti-1318	364	4	µm	µm	NOUN
dti-1318	364	5	suppresses	suppress	VERB
dti-1318	364	6	viral	viral	ADJ
dti-1318	364	7	p24	p24	NOUN
dti-1318	364	8	in	in	ADP
dti-1318	364	9	culture	culture	NOUN
dti-1318	364	10	supernatants	supernatant	NOUN
dti-1318	364	11	to	to	ADP
dti-1318	364	12	undetectable	undetectable	ADJ
dti-1318	364	13	levels	level	NOUN
dti-1318	364	14	for	for	ADP
dti-1318	364	15	more	more	ADJ
dti-1318	364	16	than	than	ADP
dti-1318	364	17	10	10	NUM
dti-1318	364	18	days	day	NOUN
dti-1318	364	19	in	in	ADP
dti-1318	364	20	culture	culture	NOUN
dti-1318	364	21	(	(	PUNCT
dti-1318	364	22	ewart	ewart	PROPN
dti-1318	364	23	et	et	PROPN
dti-1318	364	24	al	al	PROPN
dti-1318	364	25	.	.	PROPN
dti-1318	364	26	2004	2004	NUM
dti-1318	364	27	)	)	PUNCT
dti-1318	364	28	.	.	PUNCT
dti-1318	365	1	while	while	SCONJ
dti-1318	365	2	amiloride	amiloride	ADJ
dti-1318	365	3	analogues	analogue	NOUN
dti-1318	365	4	demonstrate	demonstrate	VERB
dti-1318	365	5	activity	activity	NOUN
dti-1318	365	6	in	in	ADP
dti-1318	365	7	macrophages	macrophage	NOUN
dti-1318	365	8	,	,	PUNCT
dti-1318	365	9	they	they	PRON
dti-1318	365	10	fail	fail	VERB
dti-1318	365	11	to	to	PART
dti-1318	365	12	inhibit	inhibit	VERB
dti-1318	365	13	hiv-1	hiv-1	X
dti-1318	365	14	replication	replication	NOUN
dti-1318	365	15	in	in	ADP
dti-1318	365	16	t	t	PROPN
dti-1318	365	17	-	-	PUNCT
dti-1318	365	18	cells	cell	NOUN
dti-1318	365	19	(	(	PUNCT
dti-1318	365	20	ewart	ewart	NOUN
dti-1318	365	21	et	et	PROPN
dti-1318	365	22	al	al	PROPN
dti-1318	365	23	.	.	PROPN
dti-1318	365	24	2002	2002	NUM
dti-1318	365	25	)	)	PUNCT
dti-1318	365	26	.	.	PUNCT
dti-1318	366	1	nevertheless	nevertheless	ADV
dti-1318	366	2	,	,	PUNCT
dti-1318	366	3	vpu	vpu	ADP
dti-1318	366	4	ion	ion	NOUN
dti-1318	366	5	channel	channel	NOUN
dti-1318	366	6	inhibitors	inhibitor	NOUN
dti-1318	366	7	have	have	VERB
dti-1318	366	8	the	the	DET
dti-1318	366	9	potential	potential	NOUN
dti-1318	366	10	for	for	ADP
dti-1318	366	11	use	use	NOUN
dti-1318	366	12	in	in	ADP
dti-1318	366	13	combination	combination	NOUN
dti-1318	366	14	therapy	therapy	NOUN
dti-1318	366	15	,	,	PUNCT
dti-1318	366	16	targeting	target	VERB
dti-1318	366	17	viral	viral	ADJ
dti-1318	366	18	reservoirs	reservoir	NOUN
dti-1318	366	19	and	and	CCONJ
dti-1318	366	20	drug	drug	NOUN
dti-1318	366	21	-	-	PUNCT
dti-1318	366	22	resistant	resistant	ADJ
dti-1318	366	23	variants	variant	NOUN
dti-1318	366	24	.	.	PUNCT
dti-1318	367	1	an	an	DET
dti-1318	367	2	amiloride	amiloride	ADJ
dti-1318	367	3	derivative	derivative	NOUN
dti-1318	367	4	,	,	PUNCT
dti-1318	367	5	bit225	bit225	PROPN
dti-1318	367	6	,	,	PUNCT
dti-1318	367	7	is	be	AUX
dti-1318	367	8	currently	currently	ADV
dti-1318	367	9	being	be	AUX
dti-1318	367	10	pursued	pursue	VERB
dti-1318	367	11	for	for	ADP
dti-1318	367	12	drug	drug	NOUN
dti-1318	367	13	development	development	NOUN
dti-1318	367	14	(	(	PUNCT
dti-1318	367	15	biotron	biotron	PROPN
dti-1318	367	16	limited	limited	ADJ
dti-1318	367	17	,	,	PUNCT
dti-1318	367	18	sydney	sydney	PROPN
dti-1318	367	19	,	,	PUNCT
dti-1318	367	20	nsw	nsw	PROPN
dti-1318	367	21	,	,	PUNCT
dti-1318	367	22	australia	australia	PROPN
dti-1318	367	23	)	)	PUNCT
dti-1318	367	24	.	.	PUNCT
dti-1318	368	1	bit225	bit225	PROPN
dti-1318	368	2	represents	represent	VERB
dti-1318	368	3	a	a	DET
dti-1318	368	4	promising	promising	ADJ
dti-1318	368	5	antiretroviral	antiretroviral	ADJ
dti-1318	368	6	therapeutic	therapeutic	ADJ
dti-1318	368	7	although	although	SCONJ
dti-1318	368	8	the	the	DET
dti-1318	368	9	evaluation	evaluation	NOUN
dti-1318	368	10	of	of	ADP
dti-1318	368	11	its	its	PRON
dti-1318	368	12	in	in	ADP
dti-1318	368	13	vivo	vivo	NOUN
dti-1318	368	14	effi	effi	PROPN
dti-1318	368	15	cacy	cacy	NOUN
dti-1318	368	16	will	will	AUX
dti-1318	368	17	present	present	VERB
dti-1318	368	18	a	a	DET
dti-1318	368	19	challenge	challenge	NOUN
dti-1318	368	20	since	since	SCONJ
dti-1318	368	21	inhibition	inhibition	NOUN
dti-1318	368	22	of	of	ADP
dti-1318	368	23	hiv-1	hiv-1	X
dti-1318	368	24	replication	replication	NOUN
dti-1318	368	25	appears	appear	VERB
dti-1318	368	26	to	to	PART
dti-1318	368	27	be	be	AUX
dti-1318	368	28	restricted	restrict	VERB
dti-1318	368	29	to	to	ADP
dti-1318	368	30	nonproliferating	nonproliferate	VERB
dti-1318	368	31	cells	cell	NOUN
dti-1318	368	32	.	.	PUNCT
dti-1318	369	1	recent	recent	ADJ
dti-1318	369	2	studies	study	NOUN
dti-1318	369	3	also	also	ADV
dti-1318	369	4	suggest	suggest	VERB
dti-1318	369	5	that	that	SCONJ
dti-1318	369	6	rimantadine	rimantadine	NOUN
dti-1318	369	7	,	,	PUNCT
dti-1318	369	8	an	an	DET
dti-1318	369	9	ion	ion	NOUN
dti-1318	369	10	channel	channel	NOUN
dti-1318	369	11	blocker	blocker	NOUN
dti-1318	369	12	of	of	ADP
dti-1318	369	13	infl	infl	PROPN
dti-1318	369	14	uenza	uenza	PROPN
dti-1318	369	15	a	a	DET
dti-1318	369	16	viruses	virus	NOUN
dti-1318	369	17	,	,	PUNCT
dti-1318	369	18	can	can	AUX
dti-1318	369	19	be	be	AUX
dti-1318	369	20	a	a	DET
dti-1318	369	21	useful	useful	ADJ
dti-1318	369	22	lead	lead	NOUN
dti-1318	369	23	compound	compound	NOUN
dti-1318	369	24	for	for	ADP
dti-1318	369	25	designing	design	VERB
dti-1318	369	26	vpu	vpu	NOUN
dti-1318	369	27	inhibitors	inhibitor	NOUN
dti-1318	369	28	.	.	PUNCT
dti-1318	370	1	rimantadine	rimantadine	NOUN
dti-1318	370	2	and	and	CCONJ
dti-1318	370	3	amantadine	amantadine	NOUN
dti-1318	370	4	belong	belong	VERB
dti-1318	370	5	to	to	ADP
dti-1318	370	6	class	class	NOUN
dti-1318	370	7	of	of	ADP
dti-1318	370	8	polycyclic	polycyclic	NOUN
dti-1318	370	9	amines	amine	NOUN
dti-1318	370	10	that	that	PRON
dti-1318	370	11	are	be	AUX
dti-1318	370	12	active	active	ADJ
dti-1318	370	13	against	against	ADP
dti-1318	370	14	the	the	DET
dti-1318	370	15	m2	m2	PROPN
dti-1318	370	16	ion	ion	NOUN
dti-1318	370	17	channel	channel	NOUN
dti-1318	370	18	of	of	ADP
dti-1318	370	19	infl	infl	PROPN
dti-1318	370	20	uenza	uenza	PROPN
dti-1318	370	21	a	a	PRON
dti-1318	370	22	but	but	CCONJ
dti-1318	370	23	not	not	PART
dti-1318	370	24	against	against	ADP
dti-1318	370	25	hiv-1	hiv-1	PUNCT
dti-1318	370	26	vpu	vpu	NOUN
dti-1318	370	27	(	(	PUNCT
dti-1318	370	28	hout	hout	PROPN
dti-1318	370	29	et	et	PROPN
dti-1318	370	30	al	al	PROPN
dti-1318	370	31	.	.	PROPN
dti-1318	370	32	2006	2006	NUM
dti-1318	370	33	)	)	PUNCT
dti-1318	370	34	.	.	PUNCT
dti-1318	371	1	studies	study	NOUN
dti-1318	371	2	indicate	indicate	VERB
dti-1318	371	3	that	that	SCONJ
dti-1318	371	4	mutating	mutate	VERB
dti-1318	371	5	histidine	histidine	NOUN
dti-1318	371	6	at	at	ADP
dti-1318	371	7	residue	residue	NOUN
dti-1318	371	8	19	19	NUM
dti-1318	371	9	to	to	ADP
dti-1318	371	10	alanine	alanine	NOUN
dti-1318	371	11	results	result	NOUN
dti-1318	371	12	in	in	ADP
dti-1318	371	13	a	a	DET
dti-1318	371	14	rimantadine	rimantadine	NOUN
dti-1318	371	15	sensitive	sensitive	ADJ
dti-1318	371	16	vpu	vpu	NOUN
dti-1318	371	17	ion	ion	NOUN
dti-1318	371	18	channel	channel	NOUN
dti-1318	371	19	demonstrating	demonstrate	VERB
dti-1318	371	20	the	the	DET
dti-1318	371	21	potential	potential	NOUN
dti-1318	371	22	of	of	ADP
dti-1318	371	23	this	this	DET
dti-1318	371	24	class	class	NOUN
dti-1318	371	25	of	of	ADP
dti-1318	371	26	inhibitor	inhibitor	NOUN
dti-1318	371	27	as	as	ADP
dti-1318	371	28	hiv-1	hiv-1	VERB
dti-1318	371	29	ion	ion	NOUN
dti-1318	371	30	channel	channel	NOUN
dti-1318	371	31	blockers	blocker	NOUN
dti-1318	371	32	(	(	PUNCT
dti-1318	371	33	hout	hout	PROPN
dti-1318	371	34	et	et	PROPN
dti-1318	371	35	al	al	PROPN
dti-1318	371	36	.	.	PROPN
dti-1318	371	37	2006	2006	NUM
dti-1318	371	38	)	)	PUNCT
dti-1318	371	39	.	.	PUNCT
dti-1318	372	1	vpu	vpu	NOUN
dti-1318	372	2	is	be	AUX
dti-1318	372	3	also	also	ADV
dti-1318	372	4	implicated	implicate	VERB
dti-1318	372	5	to	to	PART
dti-1318	372	6	interact	interact	VERB
dti-1318	372	7	with	with	ADP
dti-1318	372	8	certain	certain	ADJ
dti-1318	372	9	host	host	NOUN
dti-1318	372	10	cell	cell	NOUN
dti-1318	372	11	restriction	restriction	NOUN
dti-1318	372	12	factors	factor	NOUN
dti-1318	372	13	that	that	PRON
dti-1318	372	14	interfere	interfere	VERB
dti-1318	372	15	with	with	ADP
dti-1318	372	16	viral	viral	ADJ
dti-1318	372	17	particle	particle	NOUN
dti-1318	372	18	egress	egress	NOUN
dti-1318	372	19	.	.	PUNCT
dti-1318	373	1	the	the	DET
dti-1318	373	2	host	host	NOUN
dti-1318	373	3	cell	cell	NOUN
dti-1318	373	4	protein	protein	NOUN
dti-1318	373	5	,	,	PUNCT
dti-1318	373	6	vpu	vpu	NOUN
dti-1318	373	7	-	-	PUNCT
dti-1318	373	8	binding	bind	VERB
dti-1318	373	9	protein	protein	NOUN
dti-1318	373	10	(	(	PUNCT
dti-1318	373	11	ubp	ubp	NOUN
dti-1318	373	12	)	)	PUNCT
dti-1318	373	13	,	,	PUNCT
dti-1318	373	14	is	be	AUX
dti-1318	373	15	suggested	suggest	VERB
dti-1318	373	16	to	to	PART
dti-1318	373	17	be	be	AUX
dti-1318	373	18	a	a	DET
dti-1318	373	19	negative	negative	ADJ
dti-1318	373	20	factor	factor	NOUN
dti-1318	373	21	for	for	ADP
dti-1318	373	22	virus	virus	NOUN
dti-1318	373	23	assembly	assembly	NOUN
dti-1318	373	24	(	(	PUNCT
dti-1318	373	25	callahan	callahan	PROPN
dti-1318	373	26	et	et	PROPN
dti-1318	373	27	al	al	PROPN
dti-1318	373	28	.	.	PROPN
dti-1318	373	29	1998	1998	NUM
dti-1318	373	30	;	;	PUNCT
dti-1318	373	31	bour	bour	NOUN
dti-1318	373	32	and	and	CCONJ
dti-1318	373	33	strebel	strebel	NOUN
dti-1318	373	34	,	,	PUNCT
dti-1318	373	35	2003	2003	NUM
dti-1318	373	36	)	)	PUNCT
dti-1318	373	37	.	.	PUNCT
dti-1318	374	1	ubp	ubp	PROPN
dti-1318	374	2	is	be	AUX
dti-1318	374	3	a	a	DET
dti-1318	374	4	34	34	NUM
dti-1318	374	5	-	-	PUNCT
dti-1318	374	6	kda	kda	NOUN
dti-1318	374	7	protein	protein	NOUN
dti-1318	374	8	that	that	PRON
dti-1318	374	9	exhibits	exhibit	VERB
dti-1318	374	10	competitive	competitive	ADJ
dti-1318	374	11	binding	binding	NOUN
dti-1318	374	12	with	with	ADP
dti-1318	374	13	vpu	vpu	NOUN
dti-1318	374	14	and	and	CCONJ
dti-1318	374	15	gag	gag	PROPN
dti-1318	374	16	(	(	PUNCT
dti-1318	374	17	callahan	callahan	PROPN
dti-1318	374	18	et	et	PROPN
dti-1318	374	19	al	al	PROPN
dti-1318	374	20	.	.	PROPN
dti-1318	374	21	1998	1998	NUM
dti-1318	374	22	;	;	PUNCT
dti-1318	374	23	handley	handley	PROPN
dti-1318	374	24	et	et	PROPN
dti-1318	374	25	al	al	PROPN
dti-1318	374	26	.	.	PROPN
dti-1318	374	27	2001	2001	NUM
dti-1318	374	28	)	)	PUNCT
dti-1318	374	29	.	.	PUNCT
dti-1318	375	1	overexpression	overexpression	NOUN
dti-1318	375	2	of	of	ADP
dti-1318	375	3	ubp	ubp	NOUN
dti-1318	375	4	has	have	AUX
dti-1318	375	5	been	be	AUX
dti-1318	375	6	reported	report	VERB
dti-1318	375	7	to	to	PART
dti-1318	375	8	significantly	significantly	ADV
dti-1318	375	9	suppress	suppress	VERB
dti-1318	375	10	viral	viral	ADJ
dti-1318	375	11	particle	particle	NOUN
dti-1318	375	12	release	release	NOUN
dti-1318	375	13	suggesting	suggest	VERB
dti-1318	375	14	that	that	SCONJ
dti-1318	375	15	ubp	ubp	NOUN
dti-1318	375	16	is	be	AUX
dti-1318	375	17	a	a	DET
dti-1318	375	18	negative	negative	ADJ
dti-1318	375	19	factor	factor	NOUN
dti-1318	375	20	that	that	PRON
dti-1318	375	21	requires	require	VERB
dti-1318	375	22	displacement	displacement	NOUN
dti-1318	375	23	by	by	ADP
dti-1318	375	24	gag	gag	NOUN
dti-1318	375	25	or	or	CCONJ
dti-1318	375	26	vpu	vpu	NOUN
dti-1318	375	27	(	(	PUNCT
dti-1318	375	28	callahan	callahan	PROPN
dti-1318	375	29	et	et	PROPN
dti-1318	375	30	al	al	PROPN
dti-1318	375	31	.	.	PROPN
dti-1318	375	32	1998	1998	NUM
dti-1318	375	33	)	)	PUNCT
dti-1318	375	34	.	.	PUNCT
dti-1318	376	1	it	it	PRON
dti-1318	376	2	is	be	AUX
dti-1318	376	3	suggested	suggest	VERB
dti-1318	376	4	that	that	SCONJ
dti-1318	376	5	vpu	vpu	NOUN
dti-1318	376	6	mediates	mediate	VERB
dti-1318	376	7	its	its	PRON
dti-1318	376	8	effect	effect	NOUN
dti-1318	376	9	on	on	ADP
dti-1318	376	10	viral	viral	ADJ
dti-1318	376	11	egress	egress	NOUN
dti-1318	376	12	by	by	ADP
dti-1318	376	13	facilitating	facilitate	VERB
dti-1318	376	14	membrane	membrane	NOUN
dti-1318	376	15	targeting	targeting	NOUN
dti-1318	376	16	of	of	ADP
dti-1318	376	17	gag	gag	NOUN
dti-1318	376	18	precursors	precursor	NOUN
dti-1318	376	19	(	(	PUNCT
dti-1318	376	20	handley	handley	PROPN
dti-1318	376	21	et	et	PROPN
dti-1318	376	22	al	al	PROPN
dti-1318	376	23	.	.	PROPN
dti-1318	376	24	2001	2001	NUM
dti-1318	376	25	;	;	PUNCT
dti-1318	377	1	harila	harila	NOUN
dti-1318	377	2	et	et	PROPN
dti-1318	377	3	al	al	PROPN
dti-1318	377	4	.	.	PROPN
dti-1318	377	5	2006	2006	NUM
dti-1318	377	6	;	;	PUNCT
dti-1318	377	7	neil	neil	PROPN
dti-1318	377	8	et	et	PROPN
dti-1318	377	9	al	al	PROPN
dti-1318	377	10	.	.	PROPN
dti-1318	377	11	2006	2006	NUM
dti-1318	377	12	)	)	PUNCT
dti-1318	377	13	.	.	PUNCT
dti-1318	378	1	supporting	support	VERB
dti-1318	378	2	this	this	DET
dti-1318	378	3	notion	notion	NOUN
dti-1318	378	4	,	,	PUNCT
dti-1318	378	5	vpu	vpu	NOUN
dti-1318	378	6	-	-	PUNCT
dti-1318	378	7	defective	defective	ADJ
dti-1318	378	8	particles	particle	NOUN
dti-1318	378	9	appear	appear	VERB
dti-1318	378	10	in	in	ADP
dti-1318	378	11	internal	internal	ADJ
dti-1318	378	12	membrane	membrane	NOUN
dti-1318	378	13	-	-	PUNCT
dti-1318	378	14	bound	bind	VERB
dti-1318	378	15	compartments	compartment	NOUN
dti-1318	378	16	suggesting	suggest	VERB
dti-1318	378	17	a	a	DET
dti-1318	378	18	gag	gag	NOUN
dti-1318	378	19	targeting	target	VERB
dti-1318	378	20	defect	defect	NOUN
dti-1318	378	21	(	(	PUNCT
dti-1318	378	22	klimkait	klimkait	NOUN
dti-1318	378	23	et	et	PROPN
dti-1318	378	24	al	al	PROPN
dti-1318	378	25	.	.	PROPN
dti-1318	378	26	1990	1990	NUM
dti-1318	378	27	)	)	PUNCT
dti-1318	378	28	.	.	PUNCT
dti-1318	379	1	another	another	DET
dti-1318	379	2	host	host	NOUN
dti-1318	379	3	cell	cell	NOUN
dti-1318	379	4	restriction	restriction	NOUN
dti-1318	379	5	factor	factor	NOUN
dti-1318	379	6	implicated	implicate	VERB
dti-1318	379	7	in	in	ADP
dti-1318	379	8	viral	viral	ADJ
dti-1318	379	9	release	release	NOUN
dti-1318	379	10	is	be	AUX
dti-1318	379	11	an	an	DET
dti-1318	379	12	acid	acid	NOUN
dti-1318	379	13	-	-	PUNCT
dti-1318	379	14	sensitive	sensitive	ADJ
dti-1318	379	15	potassium	potassium	NOUN
dti-1318	379	16	channel	channel	NOUN
dti-1318	379	17	-	-	PUNCT
dti-1318	379	18	forming	form	VERB
dti-1318	379	19	protein	protein	NOUN
dti-1318	379	20	,	,	PUNCT
dti-1318	379	21	task-1	task-1	VERB
dti-1318	379	22	,	,	PUNCT
dti-1318	379	23	which	which	PRON
dti-1318	379	24	is	be	AUX
dti-1318	379	25	down	down	ADV
dti-1318	379	26	regulated	regulate	VERB
dti-1318	379	27	during	during	ADP
dti-1318	379	28	viral	viral	ADJ
dti-1318	379	29	infection	infection	NOUN
dti-1318	379	30	(	(	PUNCT
dti-1318	379	31	hsu	hsu	PROPN
dti-1318	379	32	et	et	PROPN
dti-1318	379	33	al	al	PROPN
dti-1318	379	34	.	.	PROPN
dti-1318	379	35	2004	2004	NUM
dti-1318	379	36	)	)	PUNCT
dti-1318	379	37	.	.	PUNCT
dti-1318	380	1	due	due	ADP
dti-1318	380	2	to	to	ADP
dti-1318	380	3	the	the	DET
dti-1318	380	4	structural	structural	ADJ
dti-1318	380	5	homology	homology	NOUN
dti-1318	380	6	of	of	ADP
dti-1318	380	7	task-1	task-1	NUM
dti-1318	380	8	and	and	CCONJ
dti-1318	380	9	hiv-1	hiv-1	PUNCT
dti-1318	380	10	vpu	vpu	NOUN
dti-1318	380	11	,	,	PUNCT
dti-1318	380	12	task-1	task-1	NUM
dti-1318	380	13	has	have	AUX
dti-1318	380	14	been	be	AUX
dti-1318	380	15	suggested	suggest	VERB
dti-1318	380	16	to	to	PART
dti-1318	380	17	form	form	VERB
dti-1318	380	18	hetero	hetero	NOUN
dti-1318	380	19	-	-	PUNCT
dti-1318	380	20	oligomers	oligomer	NOUN
dti-1318	380	21	with	with	ADP
dti-1318	380	22	vpu	vpu	ADP
dti-1318	380	23	which	which	PRON
dti-1318	380	24	interferes	interfere	VERB
dti-1318	380	25	with	with	ADP
dti-1318	380	26	both	both	PRON
dti-1318	380	27	task-1	task-1	NUM
dti-1318	380	28	mediated	mediate	VERB
dti-1318	380	29	conductance	conductance	NOUN
dti-1318	380	30	and	and	CCONJ
dti-1318	380	31	vpu	vpu	ADP
dti-1318	380	32	ion	ion	NOUN
dti-1318	380	33	channel	channel	NOUN
dti-1318	380	34	function	function	NOUN
dti-1318	380	35	(	(	PUNCT
dti-1318	380	36	hsu	hsu	PROPN
dti-1318	380	37	et	et	PROPN
dti-1318	380	38	al	al	PROPN
dti-1318	380	39	.	.	PROPN
dti-1318	380	40	2004	2004	NUM
dti-1318	380	41	)	)	PUNCT
dti-1318	380	42	.	.	PUNCT
dti-1318	381	1	further	further	ADJ
dti-1318	381	2	delineation	delineation	NOUN
dti-1318	381	3	of	of	ADP
dti-1318	381	4	the	the	PRON
dti-1318	381	5	how	how	SCONJ
dti-1318	381	6	these	these	DET
dti-1318	381	7	host	host	NOUN
dti-1318	381	8	cell	cell	NOUN
dti-1318	381	9	factors	factor	NOUN
dti-1318	381	10	interact	interact	VERB
dti-1318	381	11	with	with	ADP
dti-1318	381	12	vpu	vpu	NOUN
dti-1318	381	13	is	be	AUX
dti-1318	381	14	required	require	VERB
dti-1318	381	15	in	in	ADP
dti-1318	381	16	order	order	NOUN
dti-1318	381	17	to	to	PART
dti-1318	381	18	design	design	VERB
dti-1318	381	19	small	small	ADJ
dti-1318	381	20	molecule	molecule	NOUN
dti-1318	381	21	inhibitors	inhibitor	NOUN
dti-1318	381	22	that	that	PRON
dti-1318	381	23	inhibit	inhibit	VERB
dti-1318	381	24	viral	viral	ADJ
dti-1318	381	25	particle	particle	NOUN
dti-1318	381	26	release	release	NOUN
dti-1318	381	27	.	.	PUNCT
dti-1318	382	1	targeting	target	VERB
dti-1318	382	2	hiv-1	hiv-1	X
dti-1318	382	3	egress	egress	NOUN
dti-1318	382	4	mediated	mediate	VERB
dti-1318	382	5	by	by	ADP
dti-1318	382	6	the	the	DET
dti-1318	382	7	p6	p6	ADJ
dti-1318	382	8	late	late	ADJ
dti-1318	382	9	domain	domain	NOUN
dti-1318	382	10	in	in	ADP
dti-1318	382	11	the	the	DET
dti-1318	382	12	recent	recent	ADJ
dti-1318	382	13	years	year	NOUN
dti-1318	382	14	,	,	PUNCT
dti-1318	382	15	major	major	ADJ
dti-1318	382	16	advances	advance	NOUN
dti-1318	382	17	have	have	AUX
dti-1318	382	18	been	be	AUX
dti-1318	382	19	made	make	VERB
dti-1318	382	20	in	in	ADP
dti-1318	382	21	our	our	PRON
dti-1318	382	22	understanding	understanding	NOUN
dti-1318	382	23	of	of	ADP
dti-1318	382	24	how	how	SCONJ
dti-1318	382	25	hiv-1	hiv-1	ADJ
dti-1318	382	26	and	and	CCONJ
dti-1318	382	27	other	other	ADJ
dti-1318	382	28	retroviruses	retrovirus	NOUN
dti-1318	382	29	are	be	AUX
dti-1318	382	30	released	release	VERB
dti-1318	382	31	from	from	ADP
dti-1318	382	32	infected	infected	ADJ
dti-1318	382	33	cells	cell	NOUN
dti-1318	382	34	.	.	PUNCT
dti-1318	383	1	in	in	ADP
dti-1318	383	2	the	the	DET
dti-1318	383	3	early	early	ADJ
dti-1318	383	4	1990s	1990	NOUN
dti-1318	383	5	it	it	PRON
dti-1318	383	6	was	be	AUX
dti-1318	383	7	reported	report	VERB
dti-1318	383	8	that	that	SCONJ
dti-1318	383	9	mutations	mutation	NOUN
dti-1318	383	10	in	in	ADP
dti-1318	383	11	the	the	DET
dti-1318	383	12	p6	p6	ADJ
dti-1318	383	13	late	late	ADJ
dti-1318	383	14	domain	domain	NOUN
dti-1318	383	15	inhibit	inhibit	VERB
dti-1318	383	16	virion	virion	NOUN
dti-1318	383	17	particle	particle	NOUN
dti-1318	383	18	release	release	NOUN
dti-1318	383	19	(	(	PUNCT
dti-1318	383	20	gottlinger	gottlinger	NOUN
dti-1318	383	21	et	et	PROPN
dti-1318	383	22	al	al	PROPN
dti-1318	383	23	.	.	PROPN
dti-1318	383	24	1991	1991	NUM
dti-1318	383	25	)	)	PUNCT
dti-1318	383	26	.	.	PUNCT
dti-1318	384	1	moreover	moreover	ADV
dti-1318	384	2	,	,	PUNCT
dti-1318	384	3	a	a	DET
dti-1318	384	4	ptap	ptap	NOUN
dti-1318	384	5	sequence	sequence	NOUN
dti-1318	384	6	,	,	PUNCT
dti-1318	384	7	encompassing	encompass	VERB
dti-1318	384	8	amino	amino	ADJ
dti-1318	384	9	acids	acid	NOUN
dti-1318	384	10	7	7	NUM
dti-1318	384	11	to	to	PART
dti-1318	384	12	10	10	NUM
dti-1318	384	13	of	of	ADP
dti-1318	384	14	p6	p6	PROPN
dti-1318	384	15	,	,	PUNCT
dti-1318	384	16	is	be	AUX
dti-1318	384	17	critical	critical	ADJ
dti-1318	384	18	for	for	ADP
dti-1318	384	19	virus	virus	NOUN
dti-1318	384	20	particle	particle	NOUN
dti-1318	384	21	production	production	NOUN
dti-1318	384	22	(	(	PUNCT
dti-1318	384	23	huang	huang	PROPN
dti-1318	384	24	et	et	PROPN
dti-1318	384	25	al	al	PROPN
dti-1318	384	26	.	.	PROPN
dti-1318	384	27	1995	1995	NUM
dti-1318	384	28	)	)	PUNCT
dti-1318	384	29	.	.	PUNCT
dti-1318	385	1	the	the	DET
dti-1318	385	2	ptap	ptap	NOUN
dti-1318	385	3	motif	motif	NOUN
dti-1318	385	4	binds	bind	VERB
dti-1318	385	5	specifi	specifi	PROPN
dti-1318	385	6	cally	cally	ADV
dti-1318	385	7	to	to	ADP
dti-1318	385	8	the	the	DET
dti-1318	385	9	host	host	NOUN
dti-1318	385	10	cell	cell	NOUN
dti-1318	385	11	protein	protein	NOUN
dti-1318	385	12	,	,	PUNCT
dti-1318	385	13	tumor	tumor	NOUN
dti-1318	385	14	suppressor	suppressor	NOUN
dti-1318	385	15	gene	gene	NOUN
dti-1318	385	16	101	101	NUM
dti-1318	385	17	(	(	PUNCT
dti-1318	385	18	tsg101	tsg101	PROPN
dti-1318	385	19	)	)	PUNCT
dti-1318	385	20	,	,	PUNCT
dti-1318	385	21	resulting	result	VERB
dti-1318	385	22	in	in	ADP
dti-1318	385	23	the	the	DET
dti-1318	385	24	recruitment	recruitment	NOUN
dti-1318	385	25	of	of	ADP
dti-1318	385	26	components	component	NOUN
dti-1318	385	27	of	of	ADP
dti-1318	385	28	the	the	DET
dti-1318	385	29	endosomal	endosomal	ADJ
dti-1318	385	30	sorting	sort	VERB
dti-1318	385	31	complex	complex	NOUN
dti-1318	385	32	required	require	VERB
dti-1318	385	33	for	for	ADP
dti-1318	385	34	transport	transport	NOUN
dti-1318	385	35	-	-	PUNCT
dti-1318	385	36	i	i	PRON
dti-1318	385	37	(	(	PUNCT
dti-1318	385	38	escrt	escrt	NUM
dti-1318	385	39	-	-	PUNCT
dti-1318	385	40	i	i	NOUN
dti-1318	385	41	)	)	PUNCT
dti-1318	386	1	(	(	PUNCT
dti-1318	386	2	verplank	verplank	NOUN
dti-1318	386	3	et	et	PROPN
dti-1318	386	4	al	al	PROPN
dti-1318	386	5	.	.	PROPN
dti-1318	386	6	2001	2001	NUM
dti-1318	386	7	;	;	PUNCT
dti-1318	386	8	martin	martin	PROPN
dti-1318	386	9	-	-	PUNCT
dti-1318	386	10	serrano	serrano	PROPN
dti-1318	386	11	et	et	PROPN
dti-1318	386	12	al	al	PROPN
dti-1318	386	13	.	.	PROPN
dti-1318	386	14	2001	2001	NUM
dti-1318	386	15	;	;	PUNCT
dti-1318	386	16	garrus	garrus	PROPN
dti-1318	386	17	et	et	PROPN
dti-1318	386	18	al	al	PROPN
dti-1318	386	19	.	.	PROPN
dti-1318	386	20	2001	2001	NUM
dti-1318	386	21	;	;	PUNCT
dti-1318	386	22	demirov	demirov	VERB
dti-1318	386	23	et	et	PROPN
dti-1318	386	24	al	al	PROPN
dti-1318	386	25	.	.	PROPN
dti-1318	386	26	2002	2002	NUM
dti-1318	386	27	)	)	PUNCT
dti-1318	386	28	.	.	PUNCT
dti-1318	387	1	deletion	deletion	NOUN
dti-1318	387	2	of	of	ADP
dti-1318	387	3	the	the	DET
dti-1318	387	4	ptap	ptap	NOUN
dti-1318	387	5	motif	motif	NOUN
dti-1318	387	6	results	result	NOUN
dti-1318	387	7	in	in	ADP
dti-1318	387	8	approximately	approximately	ADV
dti-1318	387	9	80	80	NUM
dti-1318	387	10	%	%	NOUN
dti-1318	387	11	reduction	reduction	NOUN
dti-1318	387	12	in	in	ADP
dti-1318	387	13	hiv-1	hiv-1	X
dti-1318	387	14	particle	particle	NOUN
dti-1318	387	15	release	release	NOUN
dti-1318	387	16	.	.	PUNCT
dti-1318	388	1	similarly	similarly	ADV
dti-1318	388	2	,	,	PUNCT
dti-1318	388	3	overexpression	overexpression	NOUN
dti-1318	388	4	and	and	CCONJ
dti-1318	388	5	silencing	silencing	NOUN
dti-1318	388	6	of	of	ADP
dti-1318	388	7	tsg101	tsg101	PROPN
dti-1318	388	8	abolish	abolish	VERB
dti-1318	388	9	viral	viral	ADJ
dti-1318	388	10	egress	egress	NOUN
dti-1318	388	11	(	(	PUNCT
dti-1318	388	12	garrus	garrus	PROPN
dti-1318	388	13	et	et	PROPN
dti-1318	388	14	al	al	PROPN
dti-1318	388	15	.	.	PROPN
dti-1318	388	16	2001	2001	NUM
dti-1318	388	17	;	;	PUNCT
dti-1318	388	18	demirov	demirov	VERB
dti-1318	388	19	et	et	PROPN
dti-1318	388	20	al	al	PROPN
dti-1318	388	21	.	.	PROPN
dti-1318	388	22	2002	2002	NUM
dti-1318	388	23	;	;	PUNCT
dti-1318	388	24	goila	goila	NOUN
dti-1318	388	25	-	-	PUNCT
dti-1318	388	26	gaur	gaur	NOUN
dti-1318	388	27	et	et	PROPN
dti-1318	388	28	al	al	PROPN
dti-1318	388	29	.	.	PROPN
dti-1318	388	30	2003	2003	NUM
dti-1318	388	31	)	)	PUNCT
dti-1318	388	32	.	.	PUNCT
dti-1318	389	1	nmr	nmr	NOUN
dti-1318	389	2	structure	structure	NOUN
dti-1318	389	3	analysis	analysis	NOUN
dti-1318	389	4	of	of	ADP
dti-1318	389	5	a	a	DET
dti-1318	389	6	14	14	NUM
dti-1318	389	7	amino	amino	NOUN
dti-1318	389	8	acid	acid	NOUN
dti-1318	389	9	peptide	peptide	NOUN
dti-1318	389	10	derived	derive	VERB
dti-1318	389	11	from	from	ADP
dti-1318	389	12	p6	p6	PROPN
dti-1318	389	13	encompassing	encompass	VERB
dti-1318	389	14	the	the	DET
dti-1318	389	15	ptap	ptap	NOUN
dti-1318	389	16	motif	motif	NOUN
dti-1318	389	17	complexed	complexe	VERB
dti-1318	389	18	with	with	ADP
dti-1318	389	19	the	the	DET
dti-1318	389	20	uev	uev	PROPN
dti-1318	389	21	domain	domain	NOUN
dti-1318	389	22	of	of	ADP
dti-1318	389	23	tsg101	tsg101	PROPN
dti-1318	389	24	has	have	AUX
dti-1318	389	25	revealed	reveal	VERB
dti-1318	389	26	that	that	SCONJ
dti-1318	389	27	the	the	DET
dti-1318	389	28	ptap	ptap	NOUN
dti-1318	389	29	motif	motif	NOUN
dti-1318	389	30	binds	bind	VERB
dti-1318	389	31	to	to	ADP
dti-1318	389	32	a	a	DET
dti-1318	389	33	groove	groove	NOUN
dti-1318	389	34	in	in	ADP
dti-1318	389	35	tsg101	tsg101	PROPN
dti-1318	389	36	.	.	PUNCT
dti-1318	390	1	this	this	DET
dti-1318	390	2	binding	binding	NOUN
dti-1318	390	3	creates	create	VERB
dti-1318	390	4	two	two	NUM
dti-1318	390	5	main	main	ADJ
dti-1318	390	6	pockets	pocket	NOUN
dti-1318	390	7	:	:	PUNCT
dti-1318	390	8	the	the	DET
dti-1318	390	9	“	"	PUNCT
dti-1318	390	10	a	a	PROPN
dti-1318	390	11	-	-	PUNCT
dti-1318	390	12	p	p	NOUN
dti-1318	390	13	”	"	PUNCT
dti-1318	390	14	pocket	pocket	NOUN
dti-1318	390	15	through	through	ADP
dti-1318	390	16	contact	contact	NOUN
dti-1318	390	17	of	of	ADP
dti-1318	390	18	amino	amino	ADJ
dti-1318	390	19	acids	acid	NOUN
dti-1318	390	20	7–10	7–10	PROPN
dti-1318	390	21	and	and	CCONJ
dti-1318	390	22	the	the	DET
dti-1318	390	23	“	"	PUNCT
dti-1318	390	24	p	p	NOUN
dti-1318	390	25	”	"	PUNCT
dti-1318	390	26	pocket	pocket	NOUN
dti-1318	390	27	through	through	ADP
dti-1318	390	28	the	the	DET
dti-1318	390	29	binding	binding	NOUN
dti-1318	390	30	of	of	ADP
dti-1318	390	31	amino	amino	ADJ
dti-1318	390	32	acids	acid	NOUN
dti-1318	390	33	9–10	9–10	NOUN
dti-1318	390	34	of	of	ADP
dti-1318	390	35	the	the	DET
dti-1318	390	36	peptide	peptide	NOUN
dti-1318	390	37	(	(	PUNCT
dti-1318	390	38	pornillos	pornillos	PROPN
dti-1318	390	39	et	et	PROPN
dti-1318	390	40	al	al	PROPN
dti-1318	390	41	.	.	PROPN
dti-1318	390	42	175	175	NUM
dti-1318	390	43	targeting	target	VERB
dti-1318	390	44	the	the	DET
dti-1318	390	45	late	late	ADJ
dti-1318	390	46	stages	stage	NOUN
dti-1318	390	47	of	of	ADP
dti-1318	390	48	hiv-1	hiv-1	X
dti-1318	390	49	replication	replication	NOUN
dti-1318	390	50	drug	drug	NOUN
dti-1318	390	51	target	target	NOUN
dti-1318	390	52	insights	insight	NOUN
dti-1318	390	53	2007	2007	NUM
dti-1318	390	54	:	:	SYM
dti-1318	390	55	2	2	NUM
dti-1318	390	56	2002a	2002a	NUM
dti-1318	390	57	;	;	PUNCT
dti-1318	390	58	pornillos	pornillo	NOUN
dti-1318	390	59	et	et	PROPN
dti-1318	390	60	al	al	PROPN
dti-1318	390	61	.	.	PROPN
dti-1318	390	62	2002b	2002b	NUM
dti-1318	390	63	)	)	PUNCT
dti-1318	390	64	.	.	PUNCT
dti-1318	391	1	interruption	interruption	NOUN
dti-1318	391	2	of	of	ADP
dti-1318	391	3	this	this	DET
dti-1318	391	4	viral	viral	ADJ
dti-1318	391	5	host	host	NOUN
dti-1318	391	6	protein	protein	NOUN
dti-1318	391	7	-	-	PUNCT
dti-1318	391	8	protein	protein	NOUN
dti-1318	391	9	interaction	interaction	NOUN
dti-1318	391	10	with	with	ADP
dti-1318	391	11	compounds	compound	NOUN
dti-1318	391	12	that	that	PRON
dti-1318	391	13	bind	bind	VERB
dti-1318	391	14	to	to	ADP
dti-1318	391	15	this	this	DET
dti-1318	391	16	pocket	pocket	NOUN
dti-1318	391	17	in	in	ADP
dti-1318	391	18	tsg101	tsg101	PROPN
dti-1318	391	19	and	and	CCONJ
dti-1318	391	20	compete	compete	VERB
dti-1318	391	21	with	with	ADP
dti-1318	391	22	gag	gag	NOUN
dti-1318	391	23	would	would	AUX
dti-1318	391	24	potentially	potentially	ADV
dti-1318	391	25	inhibit	inhibit	VERB
dti-1318	391	26	viral	viral	ADJ
dti-1318	391	27	particle	particle	NOUN
dti-1318	391	28	release	release	NOUN
dti-1318	391	29	and	and	CCONJ
dti-1318	391	30	the	the	DET
dti-1318	391	31	rate	rate	NOUN
dti-1318	391	32	of	of	ADP
dti-1318	391	33	cell	cell	NOUN
dti-1318	391	34	-	-	PUNCT
dti-1318	391	35	cell	cell	NOUN
dti-1318	391	36	hiv-1	hiv-1	PUNCT
dti-1318	391	37	transmission	transmission	NOUN
dti-1318	391	38	(	(	PUNCT
dti-1318	391	39	bieniasz	bieniasz	PROPN
dti-1318	391	40	,	,	PUNCT
dti-1318	391	41	2006	2006	NUM
dti-1318	391	42	)	)	PUNCT
dti-1318	391	43	.	.	PUNCT
dti-1318	392	1	so	so	ADV
dti-1318	392	2	far	far	ADV
dti-1318	392	3	there	there	PRON
dti-1318	392	4	has	have	AUX
dti-1318	392	5	been	be	AUX
dti-1318	392	6	one	one	NUM
dti-1318	392	7	report	report	NOUN
dti-1318	392	8	that	that	PRON
dti-1318	392	9	describes	describe	VERB
dti-1318	392	10	the	the	DET
dti-1318	392	11	synthesis	synthesis	NOUN
dti-1318	392	12	and	and	CCONJ
dti-1318	392	13	selection	selection	NOUN
dti-1318	392	14	of	of	ADP
dti-1318	392	15	small	small	ADJ
dti-1318	392	16	molecules	molecule	NOUN
dti-1318	392	17	with	with	ADP
dti-1318	392	18	up	up	ADP
dti-1318	392	19	to	to	PART
dti-1318	392	20	fi	fi	NOUN
dti-1318	392	21	ve	ve	AUX
dti-1318	392	22	fold	fold	VERB
dti-1318	392	23	better	well	ADJ
dti-1318	392	24	binding	bind	VERB
dti-1318	392	25	capacity	capacity	NOUN
dti-1318	392	26	than	than	ADP
dti-1318	392	27	a	a	DET
dti-1318	392	28	peptide	peptide	NOUN
dti-1318	392	29	that	that	PRON
dti-1318	392	30	contains	contain	VERB
dti-1318	392	31	the	the	DET
dti-1318	392	32	sequence	sequence	NOUN
dti-1318	392	33	of	of	ADP
dti-1318	392	34	the	the	DET
dti-1318	392	35	wild	wild	ADJ
dti-1318	392	36	type	type	NOUN
dti-1318	392	37	ptap	ptap	NOUN
dti-1318	392	38	motif	motif	NOUN
dti-1318	392	39	in	in	ADP
dti-1318	392	40	the	the	DET
dti-1318	392	41	l	l	NOUN
dti-1318	392	42	domain	domain	NOUN
dti-1318	392	43	of	of	ADP
dti-1318	392	44	hiv-1	hiv-1	PUNCT
dti-1318	392	45	(	(	PUNCT
dti-1318	392	46	liu	liu	PROPN
dti-1318	392	47	et	et	PROPN
dti-1318	392	48	al	al	PROPN
dti-1318	392	49	.	.	PROPN
dti-1318	392	50	2006	2006	NUM
dti-1318	392	51	)	)	PUNCT
dti-1318	392	52	.	.	PUNCT
dti-1318	393	1	in	in	ADP
dti-1318	393	2	this	this	DET
dti-1318	393	3	study	study	NOUN
dti-1318	393	4	,	,	PUNCT
dti-1318	393	5	the	the	DET
dti-1318	393	6	authors	author	NOUN
dti-1318	393	7	describe	describe	VERB
dti-1318	393	8	an	an	DET
dti-1318	393	9	approach	approach	NOUN
dti-1318	393	10	previously	previously	ADV
dti-1318	393	11	employed	employ	VERB
dti-1318	393	12	to	to	PART
dti-1318	393	13	obtain	obtain	VERB
dti-1318	393	14	peptoids	peptoid	NOUN
dti-1318	393	15	in	in	ADP
dti-1318	393	16	which	which	PRON
dti-1318	393	17	a	a	DET
dti-1318	393	18	key	key	ADJ
dti-1318	393	19	proline	proline	NOUN
dti-1318	393	20	residue	residue	NOUN
dti-1318	393	21	is	be	AUX
dti-1318	393	22	substituted	substitute	VERB
dti-1318	393	23	with	with	ADP
dti-1318	393	24	glycine	glycine	NOUN
dti-1318	393	25	at	at	ADP
dti-1318	393	26	the	the	DET
dti-1318	393	27	n	n	CCONJ
dti-1318	393	28	-	-	PUNCT
dti-1318	393	29	terminus	terminus	NOUN
dti-1318	393	30	of	of	ADP
dti-1318	393	31	the	the	DET
dti-1318	393	32	parent	parent	NOUN
dti-1318	393	33	pro	pro	ADJ
dti-1318	393	34	-	-	ADJ
dti-1318	393	35	rich	rich	ADJ
dti-1318	393	36	sequence	sequence	NOUN
dti-1318	393	37	in	in	ADP
dti-1318	393	38	order	order	NOUN
dti-1318	393	39	to	to	PART
dti-1318	393	40	improve	improve	VERB
dti-1318	393	41	binding	bind	VERB
dti-1318	393	42	specifi	specifi	PROPN
dti-1318	393	43	city	city	PROPN
dti-1318	393	44	to	to	PART
dti-1318	393	45	src	src	VERB
dti-1318	393	46	homology	homology	NOUN
dti-1318	393	47	3	3	NUM
dti-1318	393	48	(	(	PUNCT
dti-1318	393	49	sh3	sh3	NOUN
dti-1318	393	50	)	)	PUNCT
dti-1318	393	51	domains	domain	NOUN
dti-1318	393	52	(	(	PUNCT
dti-1318	393	53	nguyen	nguyen	NOUN
dti-1318	393	54	et	et	PROPN
dti-1318	393	55	al	al	PROPN
dti-1318	393	56	.	.	PROPN
dti-1318	393	57	2000	2000	NUM
dti-1318	393	58	)	)	PUNCT
dti-1318	393	59	.	.	PUNCT
dti-1318	394	1	similarly	similarly	ADV
dti-1318	394	2	,	,	PUNCT
dti-1318	394	3	the	the	DET
dti-1318	394	4	proline	proline	NOUN
dti-1318	394	5	rich	rich	ADJ
dti-1318	394	6	ptap	ptap	NOUN
dti-1318	394	7	domain	domain	NOUN
dti-1318	394	8	in	in	ADP
dti-1318	394	9	p6	p6	PROPN
dti-1318	394	10	was	be	AUX
dti-1318	394	11	considered	consider	VERB
dti-1318	394	12	a	a	DET
dti-1318	394	13	good	good	ADJ
dti-1318	394	14	candidate	candidate	NOUN
dti-1318	394	15	for	for	ADP
dti-1318	394	16	the	the	DET
dti-1318	394	17	n	n	ADV
dti-1318	394	18	-	-	PUNCT
dti-1318	394	19	substituted	substitute	VERB
dti-1318	394	20	glycine	glycine	NOUN
dti-1318	394	21	residue	residue	NOUN
dti-1318	394	22	approach	approach	NOUN
dti-1318	394	23	.	.	PUNCT
dti-1318	395	1	in	in	ADP
dti-1318	395	2	this	this	DET
dti-1318	395	3	study	study	NOUN
dti-1318	395	4	,	,	PUNCT
dti-1318	395	5	the	the	DET
dti-1318	395	6	tsg101	tsg101	PROPN
dti-1318	395	7	binding	bind	VERB
dti-1318	395	8	affi	affi	PROPN
dti-1318	395	9	nity	nity	NOUN
dti-1318	395	10	(	(	PUNCT
dti-1318	395	11	kd	kd	PROPN
dti-1318	395	12	)	)	PUNCT
dti-1318	395	13	of	of	ADP
dti-1318	395	14	the	the	DET
dti-1318	395	15	9	9	NUM
dti-1318	395	16	-	-	PUNCT
dti-1318	395	17	mer	mer	NOUN
dti-1318	395	18	wild	wild	ADJ
dti-1318	395	19	-	-	PUNCT
dti-1318	395	20	type	type	NOUN
dti-1318	395	21	ptap	ptap	NOUN
dti-1318	395	22	containing	contain	VERB
dti-1318	395	23	peptide	peptide	NOUN
dti-1318	395	24	was	be	AUX
dti-1318	395	25	50	50	NUM
dti-1318	395	26	µm	µm	NOUN
dti-1318	395	27	(	(	PUNCT
dti-1318	395	28	liu	liu	PROPN
dti-1318	395	29	et	et	PROPN
dti-1318	395	30	al	al	PROPN
dti-1318	395	31	.	.	PROPN
dti-1318	395	32	2006	2006	NUM
dti-1318	395	33	)	)	PUNCT
dti-1318	395	34	.	.	PUNCT
dti-1318	396	1	binding	bind	VERB
dti-1318	396	2	constants	constant	NOUN
dti-1318	396	3	for	for	ADP
dti-1318	396	4	the	the	DET
dti-1318	396	5	highest	high	ADJ
dti-1318	396	6	affi	affi	ADJ
dti-1318	396	7	nity	nity	NOUN
dti-1318	396	8	peptoidhydrazones	peptoidhydrazone	NOUN
dti-1318	396	9	(	(	PUNCT
dti-1318	396	10	designated	designate	VERB
dti-1318	396	11	11q	11q	NOUN
dti-1318	396	12	and	and	CCONJ
dti-1318	396	13	11p	11p	NUM
dti-1318	396	14	)	)	PUNCT
dti-1318	396	15	were	be	AUX
dti-1318	396	16	17.5	17.5	NUM
dti-1318	396	17	and	and	CCONJ
dti-1318	396	18	9.8	9.8	NUM
dti-1318	396	19	µm	µm	NOUN
dti-1318	396	20	,	,	PUNCT
dti-1318	396	21	respectively	respectively	ADV
dti-1318	396	22	.	.	PUNCT
dti-1318	397	1	the	the	DET
dti-1318	397	2	highest	high	ADJ
dti-1318	397	3	affi	affi	ADJ
dti-1318	397	4	nity	nity	NOUN
dti-1318	397	5	peptoid	peptoid	ADJ
dti-1318	397	6	hydrazone	hydrazone	NOUN
dti-1318	397	7	was	be	AUX
dti-1318	397	8	found	find	VERB
dti-1318	397	9	to	to	PART
dti-1318	397	10	be	be	AUX
dti-1318	397	11	the	the	DET
dti-1318	397	12	n	n	CCONJ
dti-1318	397	13	-	-	PUNCT
dti-1318	397	14	butyl	butyl	NOUN
dti-1318	397	15	-	-	PUNCT
dti-1318	397	16	containing	contain	VERB
dti-1318	397	17	11p	11p	NOUN
dti-1318	397	18	peptide	peptide	NOUN
dti-1318	397	19	,	,	PUNCT
dti-1318	397	20	with	with	ADP
dti-1318	397	21	a	a	DET
dti-1318	397	22	fi	fi	NOUN
dti-1318	397	23	ve	ve	NOUN
dti-1318	397	24	-	-	ADJ
dti-1318	397	25	fold	fold	ADJ
dti-1318	397	26	increase	increase	NOUN
dti-1318	397	27	in	in	ADP
dti-1318	397	28	binding	bind	VERB
dti-1318	397	29	affi	affi	ADJ
dti-1318	397	30	nity	nity	NOUN
dti-1318	397	31	compared	compare	VERB
dti-1318	397	32	to	to	ADP
dti-1318	397	33	the	the	DET
dti-1318	397	34	wild	wild	ADJ
dti-1318	397	35	-	-	PUNCT
dti-1318	397	36	type	type	NOUN
dti-1318	397	37	9	9	NUM
dti-1318	397	38	-	-	PUNCT
dti-1318	397	39	mer	mer	NOUN
dti-1318	397	40	ptap	ptap	NOUN
dti-1318	397	41	peptide	peptide	NOUN
dti-1318	397	42	.	.	PUNCT
dti-1318	398	1	the	the	DET
dti-1318	398	2	capacity	capacity	NOUN
dti-1318	398	3	of	of	ADP
dti-1318	398	4	these	these	DET
dti-1318	398	5	peptides	peptide	NOUN
dti-1318	398	6	to	to	PART
dti-1318	398	7	compete	compete	VERB
dti-1318	398	8	with	with	ADP
dti-1318	398	9	hiv-1	hiv-1	PUNCT
dti-1318	398	10	gag	gag	NOUN
dti-1318	398	11	for	for	ADP
dti-1318	398	12	tsg101	tsg101	PROPN
dti-1318	398	13	binding	bind	VERB
dti-1318	398	14	and	and	CCONJ
dti-1318	398	15	their	their	PRON
dti-1318	398	16	effect	effect	NOUN
dti-1318	398	17	on	on	ADP
dti-1318	398	18	hiv-1	hiv-1	X
dti-1318	398	19	egress	egress	NOUN
dti-1318	398	20	in	in	ADP
dti-1318	398	21	vitro	vitro	X
dti-1318	398	22	and	and	CCONJ
dti-1318	398	23	in	in	ADP
dti-1318	398	24	vivo	vivo	NOUN
dti-1318	398	25	remains	remain	VERB
dti-1318	398	26	to	to	PART
dti-1318	398	27	be	be	AUX
dti-1318	398	28	determined	determine	VERB
dti-1318	398	29	.	.	PUNCT
dti-1318	399	1	although	although	SCONJ
dti-1318	399	2	disruption	disruption	NOUN
dti-1318	399	3	of	of	ADP
dti-1318	399	4	viral	viral	ADJ
dti-1318	399	5	-	-	PUNCT
dti-1318	399	6	host	host	NOUN
dti-1318	399	7	cell	cell	NOUN
dti-1318	399	8	interactions	interaction	NOUN
dti-1318	399	9	is	be	AUX
dti-1318	399	10	a	a	DET
dti-1318	399	11	very	very	ADV
dti-1318	399	12	attractive	attractive	ADJ
dti-1318	399	13	approach	approach	NOUN
dti-1318	399	14	to	to	PART
dti-1318	399	15	abolish	abolish	VERB
dti-1318	399	16	virion	virion	NOUN
dti-1318	399	17	release	release	NOUN
dti-1318	399	18	and	and	CCONJ
dti-1318	399	19	infectivity	infectivity	NOUN
dti-1318	399	20	,	,	PUNCT
dti-1318	399	21	interfering	interfere	VERB
dti-1318	399	22	with	with	ADP
dti-1318	399	23	the	the	DET
dti-1318	399	24	host	host	NOUN
dti-1318	399	25	cell	cell	NOUN
dti-1318	399	26	machinery	machinery	NOUN
dti-1318	399	27	could	could	AUX
dti-1318	399	28	have	have	VERB
dti-1318	399	29	major	major	ADJ
dti-1318	399	30	consequences	consequence	NOUN
dti-1318	399	31	for	for	ADP
dti-1318	399	32	the	the	DET
dti-1318	399	33	host	host	NOUN
dti-1318	399	34	(	(	PUNCT
dti-1318	399	35	bieniasz	bieniasz	PROPN
dti-1318	399	36	,	,	PUNCT
dti-1318	399	37	2006	2006	NUM
dti-1318	399	38	)	)	PUNCT
dti-1318	399	39	.	.	PUNCT
dti-1318	400	1	tsg101	tsg101	PROPN
dti-1318	400	2	is	be	AUX
dti-1318	400	3	a	a	DET
dti-1318	400	4	multifunctional	multifunctional	ADJ
dti-1318	400	5	protein	protein	NOUN
dti-1318	400	6	and	and	CCONJ
dti-1318	400	7	plays	play	VERB
dti-1318	400	8	a	a	DET
dti-1318	400	9	critical	critical	ADJ
dti-1318	400	10	role	role	NOUN
dti-1318	400	11	in	in	ADP
dti-1318	400	12	cell	cell	NOUN
dti-1318	400	13	proliferation	proliferation	NOUN
dti-1318	400	14	as	as	SCONJ
dti-1318	400	15	shown	show	VERB
dti-1318	400	16	by	by	ADP
dti-1318	400	17	studies	study	NOUN
dti-1318	400	18	conducted	conduct	VERB
dti-1318	400	19	in	in	ADP
dti-1318	400	20	tsg101	tsg101	PROPN
dti-1318	400	21	defi	defi	NOUN
dti-1318	400	22	cient	cient	NOUN
dti-1318	400	23	mice	mouse	NOUN
dti-1318	400	24	(	(	PUNCT
dti-1318	400	25	ruland	ruland	NOUN
dti-1318	400	26	et	et	PROPN
dti-1318	400	27	al	al	PROPN
dti-1318	400	28	.	.	PROPN
dti-1318	400	29	2001	2001	NUM
dti-1318	400	30	)	)	PUNCT
dti-1318	400	31	.	.	PUNCT
dti-1318	401	1	tsg101	tsg101	PROPN
dti-1318	401	2	is	be	AUX
dti-1318	401	3	involved	involve	VERB
dti-1318	401	4	in	in	ADP
dti-1318	401	5	cellular	cellular	ADJ
dti-1318	401	6	transcription	transcription	NOUN
dti-1318	401	7	and	and	CCONJ
dti-1318	401	8	plays	play	VERB
dti-1318	401	9	a	a	DET
dti-1318	401	10	central	central	ADJ
dti-1318	401	11	role	role	NOUN
dti-1318	401	12	in	in	ADP
dti-1318	401	13	endosomal	endosomal	ADJ
dti-1318	401	14	sorting	sorting	NOUN
dti-1318	401	15	of	of	ADP
dti-1318	401	16	cargo	cargo	NOUN
dti-1318	401	17	protein	protein	NOUN
dti-1318	401	18	that	that	PRON
dti-1318	401	19	is	be	AUX
dti-1318	401	20	destined	destine	VERB
dti-1318	401	21	for	for	ADP
dti-1318	401	22	degradation	degradation	NOUN
dti-1318	401	23	by	by	ADP
dti-1318	401	24	the	the	DET
dti-1318	401	25	proteasome	proteasome	NOUN
dti-1318	401	26	.	.	PUNCT
dti-1318	402	1	tsg101	tsg101	PROPN
dti-1318	402	2	is	be	AUX
dti-1318	402	3	recruited	recruit	VERB
dti-1318	402	4	to	to	ADP
dti-1318	402	5	the	the	DET
dti-1318	402	6	endosomal	endosomal	ADJ
dti-1318	402	7	sorting	sort	VERB
dti-1318	402	8	pathway	pathway	NOUN
dti-1318	402	9	by	by	ADP
dti-1318	402	10	a	a	DET
dti-1318	402	11	specifi	specifi	PROPN
dti-1318	402	12	c	c	NOUN
dti-1318	402	13	interaction	interaction	NOUN
dti-1318	402	14	with	with	ADP
dti-1318	402	15	the	the	DET
dti-1318	402	16	host	host	NOUN
dti-1318	402	17	cell	cell	NOUN
dti-1318	402	18	protein	protein	NOUN
dti-1318	402	19	,	,	PUNCT
dti-1318	402	20	hepatocyte	hepatocyte	NOUN
dti-1318	402	21	growth	growth	NOUN
dti-1318	402	22	factor	factor	NOUN
dti-1318	402	23	-	-	PUNCT
dti-1318	402	24	regulated	regulate	VERB
dti-1318	402	25	tyrosine	tyrosine	NOUN
dti-1318	402	26	kinase	kinase	NOUN
dti-1318	402	27	substrate	substrate	NOUN
dti-1318	402	28	(	(	PUNCT
dti-1318	402	29	hrs	hrs	NOUN
dti-1318	402	30	)	)	PUNCT
dti-1318	402	31	,	,	PUNCT
dti-1318	402	32	which	which	PRON
dti-1318	402	33	binds	bind	VERB
dti-1318	402	34	to	to	ADP
dti-1318	402	35	tsg101	tsg101	PROPN
dti-1318	402	36	through	through	ADP
dti-1318	402	37	a	a	DET
dti-1318	402	38	psap	psap	PROPN
dti-1318	402	39	motif	motif	NOUN
dti-1318	402	40	(	(	PUNCT
dti-1318	402	41	lu	lu	NOUN
dti-1318	402	42	et	et	PROPN
dti-1318	402	43	al	al	PROPN
dti-1318	402	44	.	.	PROPN
dti-1318	402	45	2003	2003	NUM
dti-1318	402	46	)	)	PUNCT
dti-1318	402	47	.	.	PUNCT
dti-1318	403	1	disruption	disruption	NOUN
dti-1318	403	2	of	of	ADP
dti-1318	403	3	this	this	DET
dti-1318	403	4	interaction	interaction	NOUN
dti-1318	403	5	inhibits	inhibit	VERB
dti-1318	403	6	delivery	delivery	NOUN
dti-1318	403	7	of	of	ADP
dti-1318	403	8	epidermal	epidermal	ADJ
dti-1318	403	9	growth	growth	NOUN
dti-1318	403	10	factor	factor	NOUN
dti-1318	403	11	receptor	receptor	NOUN
dti-1318	403	12	(	(	PUNCT
dti-1318	403	13	egfr	egfr	X
dti-1318	403	14	)	)	PUNCT
dti-1318	403	15	to	to	ADP
dti-1318	403	16	the	the	DET
dti-1318	403	17	late	late	ADJ
dti-1318	403	18	endosomes	endosome	NOUN
dti-1318	403	19	.	.	PUNCT
dti-1318	404	1	in	in	ADP
dti-1318	404	2	recruiting	recruit	VERB
dti-1318	404	3	tsg101	tsg101	PROPN
dti-1318	404	4	,	,	PUNCT
dti-1318	404	5	it	it	PRON
dti-1318	404	6	is	be	AUX
dti-1318	404	7	believed	believe	VERB
dti-1318	404	8	that	that	SCONJ
dti-1318	404	9	hiv-1	hiv-1	PUNCT
dti-1318	404	10	mimics	mimic	VERB
dti-1318	404	11	hrs	hrs	NOUN
dti-1318	404	12	in	in	ADP
dti-1318	404	13	order	order	NOUN
dti-1318	404	14	to	to	PART
dti-1318	404	15	enter	enter	VERB
dti-1318	404	16	the	the	DET
dti-1318	404	17	endosomal	endosomal	ADJ
dti-1318	404	18	sorting	sort	VERB
dti-1318	404	19	pathway	pathway	NOUN
dti-1318	404	20	and	and	CCONJ
dti-1318	404	21	negotiate	negotiate	VERB
dti-1318	404	22	its	its	PRON
dti-1318	404	23	release	release	NOUN
dti-1318	404	24	from	from	ADP
dti-1318	404	25	the	the	DET
dti-1318	404	26	infected	infected	ADJ
dti-1318	404	27	cell	cell	NOUN
dti-1318	404	28	(	(	PUNCT
dti-1318	404	29	pornillos	pornillos	PROPN
dti-1318	404	30	et	et	PROPN
dti-1318	404	31	al	al	PROPN
dti-1318	404	32	.	.	PROPN
dti-1318	404	33	2003	2003	NUM
dti-1318	404	34	)	)	PUNCT
dti-1318	404	35	.	.	PUNCT
dti-1318	405	1	thus	thus	ADV
dti-1318	405	2	,	,	PUNCT
dti-1318	405	3	targeting	target	VERB
dti-1318	405	4	tsg101	tsg101	PROPN
dti-1318	405	5	would	would	AUX
dti-1318	405	6	result	result	VERB
dti-1318	405	7	in	in	ADP
dti-1318	405	8	the	the	DET
dti-1318	405	9	accumulation	accumulation	NOUN
dti-1318	405	10	of	of	ADP
dti-1318	405	11	proteins	protein	NOUN
dti-1318	405	12	at	at	ADP
dti-1318	405	13	the	the	DET
dti-1318	405	14	plasma	plasma	NOUN
dti-1318	405	15	membrane	membrane	NOUN
dti-1318	405	16	and	and	CCONJ
dti-1318	405	17	the	the	DET
dti-1318	405	18	disruption	disruption	NOUN
dti-1318	405	19	of	of	ADP
dti-1318	405	20	protein	protein	NOUN
dti-1318	405	21	sorting	sort	VERB
dti-1318	405	22	within	within	ADP
dti-1318	405	23	the	the	DET
dti-1318	405	24	infected	infected	ADJ
dti-1318	405	25	cell	cell	NOUN
dti-1318	405	26	.	.	PUNCT
dti-1318	406	1	specifi	specifi	PROPN
dti-1318	406	2	c	c	PROPN
dti-1318	406	3	inhibition	inhibition	NOUN
dti-1318	406	4	of	of	ADP
dti-1318	406	5	hiv-1	hiv-1	PUNCT
dti-1318	406	6	budding	bud	VERB
dti-1318	406	7	by	by	ADP
dti-1318	406	8	targeting	target	VERB
dti-1318	406	9	the	the	DET
dti-1318	406	10	late	late	ADJ
dti-1318	406	11	domain	domain	NOUN
dti-1318	406	12	binding	bind	VERB
dti-1318	406	13	site	site	NOUN
dti-1318	406	14	on	on	ADP
dti-1318	406	15	tsg101	tsg101	PROPN
dti-1318	406	16	will	will	AUX
dti-1318	406	17	require	require	VERB
dti-1318	406	18	preferential	preferential	ADJ
dti-1318	406	19	inhibition	inhibition	NOUN
dti-1318	406	20	of	of	ADP
dti-1318	406	21	p6	p6	ADJ
dti-1318	406	22	binding	bind	VERB
dti-1318	406	23	compared	compare	VERB
dti-1318	406	24	to	to	ADP
dti-1318	406	25	hrs	hrs	NUM
dti-1318	406	26	.	.	PUNCT
dti-1318	407	1	conclusion	conclusion	NOUN
dti-1318	407	2	considerable	considerable	ADJ
dti-1318	407	3	progress	progress	NOUN
dti-1318	407	4	has	have	AUX
dti-1318	407	5	been	be	AUX
dti-1318	407	6	made	make	VERB
dti-1318	407	7	in	in	ADP
dti-1318	407	8	understanding	understand	VERB
dti-1318	407	9	the	the	DET
dti-1318	407	10	late	late	ADJ
dti-1318	407	11	steps	step	NOUN
dti-1318	407	12	of	of	ADP
dti-1318	407	13	the	the	DET
dti-1318	407	14	viral	viral	ADJ
dti-1318	407	15	life	life	NOUN
dti-1318	407	16	-	-	PUNCT
dti-1318	407	17	cycle	cycle	NOUN
dti-1318	407	18	leading	lead	VERB
dti-1318	407	19	to	to	ADP
dti-1318	407	20	the	the	DET
dti-1318	407	21	production	production	NOUN
dti-1318	407	22	of	of	ADP
dti-1318	407	23	infectious	infectious	ADJ
dti-1318	407	24	viral	viral	ADJ
dti-1318	407	25	particles	particle	NOUN
dti-1318	407	26	.	.	PUNCT
dti-1318	408	1	many	many	ADJ
dti-1318	408	2	of	of	ADP
dti-1318	408	3	these	these	DET
dti-1318	408	4	processes	process	NOUN
dti-1318	408	5	rely	rely	VERB
dti-1318	408	6	on	on	ADP
dti-1318	408	7	protein	protein	NOUN
dti-1318	408	8	:	:	PUNCT
dti-1318	408	9	protein	protein	NOUN
dti-1318	408	10	interactions	interaction	NOUN
dti-1318	408	11	either	either	CCONJ
dti-1318	408	12	between	between	ADP
dti-1318	408	13	viral	viral	ADJ
dti-1318	408	14	proteins	protein	NOUN
dti-1318	408	15	or	or	CCONJ
dti-1318	408	16	viral	viral	ADJ
dti-1318	408	17	proteins	protein	NOUN
dti-1318	408	18	and	and	CCONJ
dti-1318	408	19	host	host	NOUN
dti-1318	408	20	cell	cell	NOUN
dti-1318	408	21	factors	factor	NOUN
dti-1318	408	22	.	.	PUNCT
dti-1318	409	1	the	the	DET
dti-1318	409	2	interactions	interaction	NOUN
dti-1318	409	3	between	between	ADP
dti-1318	409	4	the	the	DET
dti-1318	409	5	host	host	NOUN
dti-1318	409	6	and	and	CCONJ
dti-1318	409	7	viral	viral	ADJ
dti-1318	409	8	proteins	protein	NOUN
dti-1318	409	9	have	have	VERB
dti-1318	409	10	either	either	CCONJ
dti-1318	409	11	a	a	DET
dti-1318	409	12	role	role	NOUN
dti-1318	409	13	in	in	ADP
dti-1318	409	14	facilitating	facilitate	VERB
dti-1318	409	15	virus	virus	NOUN
dti-1318	409	16	replication	replication	NOUN
dti-1318	409	17	,	,	PUNCT
dti-1318	409	18	as	as	SCONJ
dti-1318	409	19	is	be	AUX
dti-1318	409	20	observed	observe	VERB
dti-1318	409	21	for	for	ADP
dti-1318	409	22	the	the	DET
dti-1318	409	23	viral	viral	ADJ
dti-1318	409	24	p6	p6	NOUN
dti-1318	409	25	and	and	CCONJ
dti-1318	409	26	tsg101	tsg101	PROPN
dti-1318	409	27	,	,	PUNCT
dti-1318	409	28	or	or	CCONJ
dti-1318	409	29	are	be	AUX
dti-1318	409	30	necessary	necessary	ADJ
dti-1318	409	31	to	to	PART
dti-1318	409	32	overcome	overcome	VERB
dti-1318	409	33	negative	negative	ADJ
dti-1318	409	34	effects	effect	NOUN
dti-1318	409	35	of	of	ADP
dti-1318	409	36	the	the	DET
dti-1318	409	37	host	host	NOUN
dti-1318	409	38	on	on	ADP
dti-1318	409	39	virus	virus	NOUN
dti-1318	409	40	replication	replication	NOUN
dti-1318	409	41	,	,	PUNCT
dti-1318	409	42	as	as	SCONJ
dti-1318	409	43	mediated	mediate	VERB
dti-1318	409	44	by	by	ADP
dti-1318	409	45	vif	vif	PROPN
dti-1318	409	46	.	.	PROPN
dti-1318	409	47	hiv-1	hiv-1	PUNCT
dti-1318	409	48	also	also	ADV
dti-1318	409	49	relies	rely	VERB
dti-1318	409	50	on	on	ADP
dti-1318	409	51	posttranslational	posttranslational	ADJ
dti-1318	409	52	modifi	modifi	NOUN
dti-1318	409	53	cations	cation	NOUN
dti-1318	409	54	mediated	mediate	VERB
dti-1318	409	55	by	by	ADP
dti-1318	409	56	the	the	DET
dti-1318	409	57	host	host	NOUN
dti-1318	409	58	cell	cell	NOUN
dti-1318	409	59	machinery	machinery	NOUN
dti-1318	409	60	in	in	ADP
dti-1318	409	61	order	order	NOUN
dti-1318	409	62	for	for	ADP
dti-1318	409	63	viral	viral	ADJ
dti-1318	409	64	polyproteins	polyprotein	NOUN
dti-1318	409	65	to	to	PART
dti-1318	409	66	be	be	AUX
dti-1318	409	67	traffi	traffi	NOUN
dti-1318	409	68	cked	cke	VERB
dti-1318	409	69	to	to	ADP
dti-1318	409	70	the	the	DET
dti-1318	409	71	appropriate	appropriate	ADJ
dti-1318	409	72	compartment	compartment	NOUN
dti-1318	409	73	of	of	ADP
dti-1318	409	74	the	the	DET
dti-1318	409	75	cell	cell	NOUN
dti-1318	409	76	for	for	ADP
dti-1318	409	77	viral	viral	ADJ
dti-1318	409	78	assembly	assembly	NOUN
dti-1318	409	79	and	and	CCONJ
dti-1318	409	80	budding	budding	NOUN
dti-1318	409	81	.	.	PUNCT
dti-1318	410	1	arguably	arguably	ADV
dti-1318	410	2	,	,	PUNCT
dti-1318	410	3	one	one	NUM
dti-1318	410	4	of	of	ADP
dti-1318	410	5	the	the	DET
dti-1318	410	6	most	most	ADV
dti-1318	410	7	effective	effective	ADJ
dti-1318	410	8	drugs	drug	NOUN
dti-1318	410	9	used	use	VERB
dti-1318	410	10	to	to	PART
dti-1318	410	11	treat	treat	VERB
dti-1318	410	12	hiv-1	hiv-1	X
dti-1318	410	13	infected	infect	VERB
dti-1318	410	14	individuals	individual	NOUN
dti-1318	410	15	are	be	AUX
dti-1318	410	16	the	the	DET
dti-1318	410	17	hiv-1	hiv-1	X
dti-1318	410	18	pr	pr	NOUN
dti-1318	410	19	inhibitors	inhibitor	NOUN
dti-1318	410	20	that	that	PRON
dti-1318	410	21	block	block	VERB
dti-1318	410	22	viral	viral	ADJ
dti-1318	410	23	maturation	maturation	NOUN
dti-1318	410	24	.	.	PUNCT
dti-1318	411	1	this	this	PRON
dti-1318	411	2	underscores	underscore	VERB
dti-1318	411	3	the	the	DET
dti-1318	411	4	effectiveness	effectiveness	NOUN
dti-1318	411	5	of	of	ADP
dti-1318	411	6	targeting	target	VERB
dti-1318	411	7	the	the	DET
dti-1318	411	8	late	late	ADJ
dti-1318	411	9	stage	stage	NOUN
dti-1318	411	10	of	of	ADP
dti-1318	411	11	virus	virus	NOUN
dti-1318	411	12	replication	replication	NOUN
dti-1318	411	13	.	.	PUNCT
dti-1318	412	1	nevertheless	nevertheless	ADV
dti-1318	412	2	,	,	PUNCT
dti-1318	412	3	while	while	SCONJ
dti-1318	412	4	some	some	PRON
dti-1318	412	5	of	of	ADP
dti-1318	412	6	the	the	DET
dti-1318	412	7	strategies	strategy	NOUN
dti-1318	412	8	described	describe	VERB
dti-1318	412	9	in	in	ADP
dti-1318	412	10	this	this	DET
dti-1318	412	11	review	review	NOUN
dti-1318	412	12	inhibit	inhibit	VERB
dti-1318	412	13	virus	virus	NOUN
dti-1318	412	14	replication	replication	NOUN
dti-1318	412	15	in	in	ADP
dti-1318	412	16	cell	cell	NOUN
dti-1318	412	17	culture	culture	NOUN
dti-1318	412	18	assays	assay	NOUN
dti-1318	412	19	,	,	PUNCT
dti-1318	412	20	they	they	PRON
dti-1318	412	21	require	require	VERB
dti-1318	412	22	improvements	improvement	NOUN
dti-1318	412	23	in	in	ADP
dti-1318	412	24	potency	potency	NOUN
dti-1318	412	25	,	,	PUNCT
dti-1318	412	26	specifi	specifi	PROPN
dti-1318	412	27	city	city	PROPN
dti-1318	412	28	and	and	CCONJ
dti-1318	412	29	delivery	delivery	NOUN
dti-1318	412	30	before	before	ADP
dti-1318	412	31	being	be	AUX
dti-1318	412	32	viable	viable	ADJ
dti-1318	412	33	for	for	ADP
dti-1318	412	34	use	use	NOUN
dti-1318	412	35	in	in	ADP
dti-1318	412	36	the	the	DET
dti-1318	412	37	clinic	clinic	NOUN
dti-1318	412	38	.	.	PUNCT
dti-1318	413	1	acknowledgements	acknowledgement	NOUN
dti-1318	413	2	j.w	j.w	PROPN
dti-1318	413	3	.	.	PROPN
dti-1318	413	4	is	be	AUX
dti-1318	413	5	supported	support	VERB
dti-1318	413	6	by	by	ADP
dti-1318	413	7	an	an	DET
dti-1318	413	8	australian	australian	ADJ
dti-1318	413	9	postgraduate	postgraduate	NOUN
dti-1318	413	10	award	award	NOUN
dti-1318	413	11	,	,	PUNCT
dti-1318	413	12	s.s	s.s	PROPN
dti-1318	413	13	.	.	PROPN
dti-1318	413	14	and	and	CCONJ
dti-1318	413	15	m.	m.	NOUN
dti-1318	413	16	s	s	NOUN
dti-1318	413	17	-	-	PUNCT
dti-1318	413	18	x	x	NOUN
dti-1318	413	19	are	be	AUX
dti-1318	413	20	supported	support	VERB
dti-1318	413	21	by	by	ADP
dti-1318	413	22	funding	funding	NOUN
dti-1318	413	23	from	from	ADP
dti-1318	413	24	the	the	DET
dti-1318	413	25	australian	australian	ADJ
dti-1318	413	26	centre	centre	NOUN
dti-1318	413	27	for	for	ADP
dti-1318	413	28	hiv	hiv	PROPN
dti-1318	413	29	and	and	CCONJ
dti-1318	413	30	hepatitis	hepatitis	NOUN
dti-1318	413	31	virology	virology	NOUN
dti-1318	413	32	research	research	NOUN
dti-1318	413	33	and	and	CCONJ
dti-1318	413	34	g.t	g.t	PROPN
dti-1318	413	35	.	.	PROPN
dti-1318	413	36	is	be	AUX
dti-1318	413	37	supported	support	VERB
dti-1318	413	38	by	by	ADP
dti-1318	413	39	funding	funding	NOUN
dti-1318	413	40	from	from	ADP
dti-1318	413	41	nhmrc	nhmrc	PROPN
dti-1318	413	42	r.d	r.d	PROPN
dti-1318	413	43	.	.	PROPN
dti-1318	413	44	wright	wright	PROPN
dti-1318	413	45	biomedical	biomedical	PROPN
dti-1318	413	46	career	career	NOUN
dti-1318	413	47	development	development	NOUN
dti-1318	413	48	grant	grant	VERB
dti-1318	413	49	235102	235102	NUM
dti-1318	413	50	and	and	CCONJ
dti-1318	413	51	nhmrc	nhmrc	NOUN
dti-1318	413	52	project	project	NOUN
dti-1318	413	53	grant	grant	NOUN
dti-1318	413	54	381703	381703	NUM
dti-1318	413	55	.	.	PUNCT
dti-1318	414	1	johanna	johanna	PROPN
dti-1318	414	2	wapling	wapling	PROPN
dti-1318	414	3	and	and	CCONJ
dti-1318	414	4	seema	seema	PROPN
dti-1318	414	5	srivastava	srivastava	PROPN
dti-1318	414	6	made	make	VERB
dti-1318	414	7	equal	equal	ADJ
dti-1318	414	8	contribution	contribution	NOUN
dti-1318	414	9	to	to	ADP
dti-1318	414	10	the	the	DET
dti-1318	414	11	review	review	NOUN
dti-1318	414	12	.	.	PUNCT
dti-1318	415	1	references	reference	NOUN
dti-1318	415	2	abdel	abdel	PROPN
dti-1318	415	3	-	-	PUNCT
dti-1318	415	4	rahman	rahman	PROPN
dti-1318	415	5	,	,	PUNCT
dti-1318	415	6	h.m	h.m	PROPN
dti-1318	415	7	.	.	PROPN
dti-1318	415	8	,	,	PUNCT
dti-1318	415	9	al	al	PROPN
dti-1318	415	10	-	-	PUNCT
dti-1318	415	11	karamany	karamany	PROPN
dti-1318	415	12	,	,	PUNCT
dti-1318	415	13	g.s	g.s	PROPN
dti-1318	415	14	.	.	PROPN
dti-1318	415	15	,	,	PUNCT
dti-1318	415	16	el	el	PROPN
dti-1318	415	17	-	-	PROPN
dti-1318	415	18	koussi	koussi	PROPN
dti-1318	415	19	,	,	PUNCT
dti-1318	415	20	n.a	n.a	PROPN
dti-1318	415	21	.	.	PROPN
dti-1318	415	22	,	,	PUNCT
dti-1318	415	23	youssef	youssef	PROPN
dti-1318	415	24	,	,	PUNCT
dti-1318	415	25	a.f	a.f	PROPN
dti-1318	415	26	.	.	PROPN
dti-1318	415	27	and	and	CCONJ
dti-1318	415	28	kiso	kiso	PROPN
dti-1318	415	29	,	,	PUNCT
dti-1318	415	30	y.	y.	PROPN
dti-1318	415	31	2002	2002	NUM
dti-1318	415	32	.	.	PUNCT
dti-1318	416	1	hiv	hiv	PROPN
dti-1318	416	2	protease	protease	NOUN
dti-1318	416	3	inhibitors	inhibitor	NOUN
dti-1318	416	4	:	:	PUNCT
dti-1318	416	5	peptidomimetic	peptidomimetic	ADJ
dti-1318	416	6	drugs	drug	NOUN
dti-1318	416	7	and	and	CCONJ
dti-1318	416	8	future	future	ADJ
dti-1318	416	9	perspectives	perspective	NOUN
dti-1318	416	10	.	.	PUNCT
dti-1318	417	1	curr	curr	AUX
dti-1318	417	2	.	.	PUNCT
dti-1318	417	3	med	med	PROPN
dti-1318	417	4	.	.	PROPN
dti-1318	417	5	chem	chem	PROPN
dti-1318	417	6	.	.	PUNCT
dti-1318	417	7	,	,	PUNCT
dti-1318	418	1	9:1905–1922	9:1905–1922	NUM
dti-1318	418	2	.	.	PUNCT
dti-1318	419	1	accola	accola	PROPN
dti-1318	419	2	,	,	PUNCT
dti-1318	419	3	m.a	m.a	PROPN
dti-1318	419	4	.	.	PROPN
dti-1318	419	5	,	,	PUNCT
dti-1318	419	6	hoglund	hoglund	PROPN
dti-1318	419	7	,	,	PUNCT
dti-1318	419	8	s.	s.	PROPN
dti-1318	419	9	and	and	CCONJ
dti-1318	419	10	gottlinger	gottlinger	PROPN
dti-1318	419	11	,	,	PUNCT
dti-1318	419	12	h.g	h.g	PROPN
dti-1318	419	13	.	.	PROPN
dti-1318	419	14	1998	1998	NUM
dti-1318	419	15	.	.	PUNCT
dti-1318	420	1	a	a	DET
dti-1318	420	2	putative	putative	ADJ
dti-1318	420	3	alphahelical	alphahelical	ADJ
dti-1318	420	4	structure	structure	NOUN
dti-1318	420	5	which	which	PRON
dti-1318	420	6	overlaps	overlap	VERB
dti-1318	420	7	the	the	DET
dti-1318	420	8	capsid	capsid	NOUN
dti-1318	420	9	-	-	PUNCT
dti-1318	420	10	p2	p2	NOUN
dti-1318	420	11	boundary	boundary	NOUN
dti-1318	420	12	in	in	ADP
dti-1318	420	13	the	the	DET
dti-1318	420	14	human	human	ADJ
dti-1318	420	15	immunodefi	immunodefi	PROPN
dti-1318	420	16	ciency	ciency	NOUN
dti-1318	420	17	virus	virus	NOUN
dti-1318	420	18	type	type	NOUN
dti-1318	420	19	1	1	NUM
dti-1318	420	20	gag	gag	NOUN
dti-1318	420	21	precursor	precursor	NOUN
dti-1318	420	22	is	be	AUX
dti-1318	420	23	crucial	crucial	ADJ
dti-1318	420	24	for	for	ADP
dti-1318	420	25	viral	viral	ADJ
dti-1318	420	26	particle	particle	NOUN
dti-1318	420	27	assembly	assembly	NOUN
dti-1318	420	28	.	.	PUNCT
dti-1318	421	1	j.	j.	PROPN
dti-1318	421	2	virol	virol	PROPN
dti-1318	421	3	.	.	PUNCT
dti-1318	421	4	,	,	PUNCT
dti-1318	421	5	72:2072–2078	72:2072–2078	X
dti-1318	421	6	.	.	NOUN
dti-1318	421	7	176	176	NUM
dti-1318	421	8	wapling	waple	VERB
dti-1318	421	9	et	et	PROPN
dti-1318	421	10	al	al	PROPN
dti-1318	421	11	drug	drug	PROPN
dti-1318	421	12	target	target	NOUN
dti-1318	421	13	insights	insight	NOUN
dti-1318	421	14	2007	2007	NUM
dti-1318	421	15	:	:	PUNCT
dti-1318	421	16	2	2	NUM
dti-1318	421	17	adamson	adamson	PROPN
dti-1318	421	18	,	,	PUNCT
dti-1318	421	19	c.s	c.s	PROPN
dti-1318	421	20	.	.	PROPN
dti-1318	421	21	,	,	PUNCT
dti-1318	421	22	ablan	ablan	PROPN
dti-1318	421	23	,	,	PUNCT
dti-1318	421	24	s.d	s.d	PROPN
dti-1318	421	25	.	.	PROPN
dti-1318	421	26	,	,	PUNCT
dti-1318	421	27	boeras	boeras	PROPN
dti-1318	421	28	,	,	PUNCT
dti-1318	421	29	i.	i.	NOUN
dti-1318	421	30	,	,	PUNCT
dti-1318	421	31	goila	goila	ADJ
dti-1318	421	32	-	-	PUNCT
dti-1318	421	33	gaur	gaur	NOUN
dti-1318	421	34	,	,	PUNCT
dti-1318	421	35	r.	r.	PROPN
dti-1318	421	36	,	,	PUNCT
dti-1318	421	37	soheilian	soheilian	PROPN
dti-1318	421	38	,	,	PUNCT
dti-1318	421	39	f.	f.	PROPN
dti-1318	421	40	,	,	PUNCT
dti-1318	421	41	nagashima	nagashima	PROPN
dti-1318	421	42	,	,	PUNCT
dti-1318	421	43	k.	k.	PROPN
dti-1318	421	44	,	,	PUNCT
dti-1318	421	45	li	li	PROPN
dti-1318	421	46	,	,	PUNCT
dti-1318	421	47	f.	f.	PROPN
dti-1318	421	48	,	,	PUNCT
dti-1318	421	49	salzwedel	salzwedel	PROPN
dti-1318	421	50	,	,	PUNCT
dti-1318	421	51	k.	k.	PROPN
dti-1318	421	52	,	,	PUNCT
dti-1318	421	53	sakalian	sakalian	NOUN
dti-1318	421	54	,	,	PUNCT
dti-1318	421	55	m.	m.	NOUN
dti-1318	421	56	,	,	PUNCT
dti-1318	421	57	wild	wild	PROPN
dti-1318	421	58	,	,	PUNCT
dti-1318	421	59	c.t	c.t	PROPN
dti-1318	421	60	.	.	PROPN
dti-1318	421	61	and	and	CCONJ
dti-1318	421	62	freed	free	VERB
dti-1318	421	63	,	,	PUNCT
dti-1318	421	64	e.o	e.o	PROPN
dti-1318	421	65	.	.	PROPN
dti-1318	421	66	2006	2006	NUM
dti-1318	421	67	.	.	PUNCT
dti-1318	422	1	in	in	ADP
dti-1318	422	2	vitro	vitro	X
dti-1318	422	3	resistance	resistance	NOUN
dti-1318	422	4	to	to	ADP
dti-1318	422	5	the	the	DET
dti-1318	422	6	human	human	ADJ
dti-1318	422	7	immunodefi	immunodefi	PROPN
dti-1318	422	8	ciency	ciency	NOUN
dti-1318	422	9	virus	virus	NOUN
dti-1318	422	10	type	type	NOUN
dti-1318	422	11	1	1	NUM
dti-1318	422	12	maturation	maturation	NOUN
dti-1318	422	13	inhibitor	inhibitor	NOUN
dti-1318	422	14	pa-457	pa-457	PROPN
dti-1318	422	15	(	(	PUNCT
dti-1318	422	16	bevirimat	bevirimat	NOUN
dti-1318	422	17	)	)	PUNCT
dti-1318	422	18	.	.	PUNCT
dti-1318	423	1	j.	j.	PROPN
dti-1318	423	2	virol	virol	PROPN
dti-1318	423	3	.	.	PUNCT
dti-1318	423	4	,	,	PUNCT
dti-1318	423	5	80:10957–10971	80:10957–10971	NUM
dti-1318	423	6	.	.	PUNCT
dti-1318	424	1	aldovini	aldovini	PROPN
dti-1318	424	2	,	,	PUNCT
dti-1318	424	3	a.	a.	NOUN
dti-1318	424	4	and	and	CCONJ
dti-1318	424	5	young	young	ADJ
dti-1318	424	6	,	,	PUNCT
dti-1318	424	7	r.a	r.a	PROPN
dti-1318	424	8	.	.	PROPN
dti-1318	424	9	1990	1990	NUM
dti-1318	424	10	.	.	PUNCT
dti-1318	425	1	mutations	mutation	NOUN
dti-1318	425	2	of	of	ADP
dti-1318	425	3	rna	rna	NOUN
dti-1318	425	4	and	and	CCONJ
dti-1318	425	5	protein	protein	NOUN
dti-1318	425	6	sequences	sequence	NOUN
dti-1318	425	7	involved	involve	VERB
dti-1318	425	8	in	in	ADP
dti-1318	425	9	human	human	ADJ
dti-1318	425	10	immunodeficiency	immunodeficiency	NOUN
dti-1318	425	11	virus	virus	NOUN
dti-1318	425	12	type	type	NOUN
dti-1318	425	13	1	1	NUM
dti-1318	425	14	packaging	packaging	NOUN
dti-1318	425	15	result	result	NOUN
dti-1318	425	16	in	in	ADP
dti-1318	425	17	production	production	NOUN
dti-1318	425	18	of	of	ADP
dti-1318	425	19	noninfectious	noninfectious	ADJ
dti-1318	425	20	virus	virus	NOUN
dti-1318	425	21	.	.	PUNCT
dti-1318	426	1	j.	j.	PROPN
dti-1318	426	2	virol	virol	PROPN
dti-1318	426	3	.	.	PUNCT
dti-1318	426	4	,	,	PUNCT
dti-1318	426	5	64:1920–1926	64:1920–1926	NUM
dti-1318	426	6	.	.	PUNCT
dti-1318	426	7	andersson	andersson	PROPN
dti-1318	426	8	,	,	PUNCT
dti-1318	426	9	e.	e.	PROPN
dti-1318	426	10	,	,	PUNCT
dti-1318	426	11	horal	horal	NOUN
dti-1318	426	12	,	,	PUNCT
dti-1318	426	13	p.	p.	NOUN
dti-1318	426	14	,	,	PUNCT
dti-1318	426	15	jejcic	jejcic	NOUN
dti-1318	426	16	,	,	PUNCT
dti-1318	426	17	a.	a.	NOUN
dti-1318	426	18	,	,	PUNCT
dti-1318	426	19	hoglund	hoglund	PROPN
dti-1318	426	20	,	,	PUNCT
dti-1318	426	21	s.	s.	PROPN
dti-1318	426	22	,	,	PUNCT
dti-1318	426	23	balzarini	balzarini	PROPN
dti-1318	426	24	,	,	PUNCT
dti-1318	426	25	j.	j.	PROPN
dti-1318	426	26	,	,	PUNCT
dti-1318	426	27	vahlne	vahlne	PROPN
dti-1318	426	28	,	,	PUNCT
dti-1318	426	29	a.	a.	NOUN
dti-1318	426	30	and	and	CCONJ
dti-1318	426	31	svennerholm	svennerholm	PROPN
dti-1318	426	32	,	,	PUNCT
dti-1318	426	33	b.	b.	PROPN
dti-1318	426	34	2005	2005	NUM
dti-1318	426	35	.	.	PUNCT
dti-1318	427	1	glycine	glycine	NOUN
dti-1318	427	2	-	-	PUNCT
dti-1318	427	3	amide	amide	NOUN
dti-1318	427	4	is	be	AUX
dti-1318	427	5	an	an	DET
dti-1318	427	6	active	active	ADJ
dti-1318	427	7	metabolite	metabolite	NOUN
dti-1318	427	8	of	of	ADP
dti-1318	427	9	the	the	DET
dti-1318	427	10	antiretroviral	antiretroviral	ADJ
dti-1318	427	11	tripeptide	tripeptide	NOUN
dti-1318	427	12	glycyl	glycyl	NOUN
dti-1318	427	13	-	-	PUNCT
dti-1318	427	14	prolyl	prolyl	VERB
dti-1318	427	15	-	-	PUNCT
dti-1318	427	16	glycine	glycine	NOUN
dti-1318	427	17	-	-	PUNCT
dti-1318	427	18	amide	amide	NOUN
dti-1318	427	19	.	.	PUNCT
dti-1318	428	1	antimicrob	antimicrob	PROPN
dti-1318	428	2	.	.	PUNCT
dti-1318	429	1	agents	agents	PROPN
dti-1318	429	2	chemother	chemother	PROPN
dti-1318	429	3	.	.	PUNCT
dti-1318	429	4	,	,	PUNCT
dti-1318	429	5	49:40–44	49:40–44	PROPN
dti-1318	429	6	.	.	PUNCT
dti-1318	429	7	andersson	andersson	PROPN
dti-1318	429	8	,	,	PUNCT
dti-1318	429	9	e.	e.	PROPN
dti-1318	429	10	,	,	PUNCT
dti-1318	429	11	horal	horal	NOUN
dti-1318	429	12	,	,	PUNCT
dti-1318	429	13	p.	p.	NOUN
dti-1318	429	14	,	,	PUNCT
dti-1318	429	15	vahlne	vahlne	PROPN
dti-1318	429	16	,	,	PUNCT
dti-1318	429	17	a.	a.	NOUN
dti-1318	429	18	and	and	CCONJ
dti-1318	429	19	svennerholm	svennerholm	PROPN
dti-1318	429	20	,	,	PUNCT
dti-1318	429	21	b.	b.	PROPN
dti-1318	429	22	2004	2004	NUM
dti-1318	429	23	.	.	PUNCT
dti-1318	430	1	no	no	DET
dti-1318	430	2	crossresistance	crossresistance	NOUN
dti-1318	430	3	or	or	CCONJ
dti-1318	430	4	selection	selection	NOUN
dti-1318	430	5	of	of	ADP
dti-1318	430	6	hiv-1	hiv-1	PUNCT
dti-1318	430	7	resistant	resistant	ADJ
dti-1318	430	8	mutants	mutant	NOUN
dti-1318	430	9	in	in	ADP
dti-1318	430	10	vitro	vitro	X
dti-1318	430	11	to	to	ADP
dti-1318	430	12	the	the	DET
dti-1318	430	13	antiretroviral	antiretroviral	ADJ
dti-1318	430	14	tripeptide	tripeptide	ADP
dti-1318	430	15	glycyl	glycyl	NOUN
dti-1318	430	16	-	-	PUNCT
dti-1318	430	17	prolyl	prolyl	VERB
dti-1318	430	18	-	-	PUNCT
dti-1318	430	19	glycine	glycine	NOUN
dti-1318	430	20	-	-	PUNCT
dti-1318	430	21	amide	amide	NOUN
dti-1318	430	22	.	.	PUNCT
dti-1318	431	1	antiviral	antiviral	ADJ
dti-1318	431	2	res	re	NOUN
dti-1318	431	3	.	.	PUNCT
dti-1318	431	4	,	,	PUNCT
dti-1318	432	1	61:119–124	61:119–124	PROPN
dti-1318	432	2	.	.	PUNCT
dti-1318	433	1	arion	arion	PROPN
dti-1318	433	2	,	,	PUNCT
dti-1318	433	3	d.	d.	PROPN
dti-1318	433	4	,	,	PUNCT
dti-1318	433	5	sluis	sluis	NOUN
dti-1318	433	6	-	-	PUNCT
dti-1318	433	7	cremer	cremer	NOUN
dti-1318	433	8	,	,	PUNCT
dti-1318	433	9	n.	n.	NOUN
dti-1318	433	10	,	,	PUNCT
dti-1318	433	11	min	min	PROPN
dti-1318	433	12	,	,	PUNCT
dti-1318	433	13	k.l	k.l	PROPN
dti-1318	433	14	.	.	PROPN
dti-1318	433	15	,	,	PUNCT
dti-1318	433	16	abram	abram	PROPN
dti-1318	433	17	,	,	PUNCT
dti-1318	433	18	m.e	m.e	PROPN
dti-1318	433	19	.	.	PROPN
dti-1318	433	20	,	,	PUNCT
dti-1318	433	21	fletcher	fletcher	PROPN
dti-1318	433	22	,	,	PUNCT
dti-1318	433	23	r.s	r.s	PROPN
dti-1318	433	24	.	.	PROPN
dti-1318	433	25	and	and	CCONJ
dti-1318	433	26	parniak	parniak	PROPN
dti-1318	433	27	,	,	PUNCT
dti-1318	433	28	m.a	m.a	PROPN
dti-1318	433	29	.	.	PROPN
dti-1318	433	30	2002	2002	NUM
dti-1318	433	31	.	.	PUNCT
dti-1318	434	1	mutational	mutational	ADJ
dti-1318	434	2	analysis	analysis	NOUN
dti-1318	434	3	of	of	ADP
dti-1318	434	4	tyr-501	tyr-501	NOUN
dti-1318	434	5	of	of	ADP
dti-1318	434	6	hiv-1	hiv-1	X
dti-1318	434	7	reverse	reverse	ADJ
dti-1318	434	8	transcriptase	transcriptase	NOUN
dti-1318	434	9	.	.	PUNCT
dti-1318	435	1	effects	effect	NOUN
dti-1318	435	2	on	on	ADP
dti-1318	435	3	ribonuclease	ribonuclease	NOUN
dti-1318	435	4	h	h	NOUN
dti-1318	435	5	activity	activity	NOUN
dti-1318	435	6	and	and	CCONJ
dti-1318	435	7	inhibition	inhibition	NOUN
dti-1318	435	8	of	of	ADP
dti-1318	435	9	this	this	DET
dti-1318	435	10	activity	activity	NOUN
dti-1318	435	11	by	by	ADP
dti-1318	435	12	n	n	NOUN
dti-1318	435	13	-	-	PUNCT
dti-1318	435	14	acylhydrazones	acylhydrazone	NOUN
dti-1318	435	15	.	.	PUNCT
dti-1318	436	1	j.	j.	PROPN
dti-1318	436	2	biol	biol	PROPN
dti-1318	436	3	.	.	PUNCT
dti-1318	437	1	chem	chem	PROPN
dti-1318	437	2	.	.	PUNCT
dti-1318	438	1	,	,	PUNCT
dti-1318	438	2	277:1370–1374	277:1370–1374	X
dti-1318	438	3	.	.	PUNCT
dti-1318	439	1	ariumi	ariumi	PROPN
dti-1318	439	2	,	,	PUNCT
dti-1318	439	3	y.	y.	PROPN
dti-1318	439	4	,	,	PUNCT
dti-1318	439	5	serhan	serhan	PROPN
dti-1318	439	6	,	,	PUNCT
dti-1318	439	7	f.	f.	PROPN
dti-1318	439	8	,	,	PUNCT
dti-1318	439	9	turelli	turelli	NOUN
dti-1318	439	10	,	,	PUNCT
dti-1318	439	11	p.	p.	NOUN
dti-1318	439	12	,	,	PUNCT
dti-1318	439	13	telenti	telenti	NOUN
dti-1318	439	14	,	,	PUNCT
dti-1318	439	15	a.	a.	NOUN
dti-1318	439	16	and	and	CCONJ
dti-1318	439	17	trono	trono	PROPN
dti-1318	439	18	,	,	PUNCT
dti-1318	439	19	d.	d.	PROPN
dti-1318	439	20	2006	2006	NUM
dti-1318	439	21	.	.	PUNCT
dti-1318	440	1	the	the	DET
dti-1318	440	2	integrase	integrase	NOUN
dti-1318	440	3	interactor	interactor	NOUN
dti-1318	440	4	1	1	NUM
dti-1318	440	5	(	(	PUNCT
dti-1318	440	6	ini1	ini1	PROPN
dti-1318	440	7	)	)	PUNCT
dti-1318	440	8	proteins	protein	NOUN
dti-1318	440	9	facilitate	facilitate	NOUN
dti-1318	440	10	tat	tat	NOUN
dti-1318	440	11	-	-	PUNCT
dti-1318	440	12	mediated	mediate	VERB
dti-1318	440	13	human	human	ADJ
dti-1318	440	14	immunodefi	immunodefi	NOUN
dti-1318	440	15	ciency	ciency	NOUN
dti-1318	440	16	virus	virus	NOUN
dti-1318	440	17	type	type	NOUN
dti-1318	440	18	1	1	NUM
dti-1318	440	19	transcription	transcription	NOUN
dti-1318	440	20	.	.	PUNCT
dti-1318	441	1	retrovirology	retrovirology	NOUN
dti-1318	441	2	,	,	PUNCT
dti-1318	441	3	3:47	3:47	NUM
dti-1318	441	4	.	.	PUNCT
dti-1318	442	1	babe	babe	NOUN
dti-1318	442	2	,	,	PUNCT
dti-1318	442	3	l.m	l.m	PROPN
dti-1318	442	4	.	.	PROPN
dti-1318	442	5	and	and	CCONJ
dti-1318	442	6	craik	craik	NOUN
dti-1318	442	7	,	,	PUNCT
dti-1318	442	8	c.s	c.s	PROPN
dti-1318	442	9	.	.	PROPN
dti-1318	442	10	1991	1991	NUM
dti-1318	442	11	.	.	PUNCT
dti-1318	443	1	time	time	NOUN
dti-1318	443	2	dependent	dependent	ADJ
dti-1318	443	3	heterodimer	heterodimer	NOUN
dti-1318	443	4	formation	formation	NOUN
dti-1318	443	5	leads	lead	VERB
dti-1318	443	6	to	to	ADP
dti-1318	443	7	inhibition	inhibition	NOUN
dti-1318	443	8	of	of	ADP
dti-1318	443	9	hiv	hiv	PROPN
dti-1318	443	10	protease	protease	NOUN
dti-1318	443	11	activity	activity	NOUN
dti-1318	443	12	.	.	PUNCT
dti-1318	444	1	adv	adv	PROPN
dti-1318	444	2	.	.	PUNCT
dti-1318	445	1	exp	exp	PROPN
dti-1318	445	2	.	.	PROPN
dti-1318	445	3	med	med	PROPN
dti-1318	445	4	.	.	PUNCT
dti-1318	446	1	biol	biol	PROPN
dti-1318	446	2	.	.	PUNCT
dti-1318	446	3	,	,	PUNCT
dti-1318	446	4	306:543–547	306:543–547	NUM
dti-1318	446	5	.	.	PUNCT
dti-1318	447	1	babe	babe	NOUN
dti-1318	447	2	,	,	PUNCT
dti-1318	447	3	l.m	l.m	PROPN
dti-1318	447	4	.	.	PROPN
dti-1318	447	5	,	,	PUNCT
dti-1318	447	6	pichuantes	pichuantes	PROPN
dti-1318	447	7	,	,	PUNCT
dti-1318	447	8	s.	s.	PROPN
dti-1318	447	9	and	and	CCONJ
dti-1318	447	10	craik	craik	PROPN
dti-1318	447	11	,	,	PUNCT
dti-1318	447	12	c.s	c.s	PROPN
dti-1318	447	13	.	.	PROPN
dti-1318	447	14	1991	1991	NUM
dti-1318	447	15	.	.	PUNCT
dti-1318	448	1	inhibition	inhibition	NOUN
dti-1318	448	2	of	of	ADP
dti-1318	448	3	hiv	hiv	NOUN
dti-1318	448	4	protease	protease	NOUN
dti-1318	448	5	activity	activity	NOUN
dti-1318	448	6	by	by	ADP
dti-1318	448	7	heterodimer	heterodimer	NOUN
dti-1318	448	8	formation	formation	NOUN
dti-1318	448	9	.	.	PUNCT
dti-1318	449	1	biochemistry	biochemistry	NOUN
dti-1318	449	2	,	,	PUNCT
dti-1318	449	3	30:106–111	30:106–111	PROPN
dti-1318	449	4	.	.	PUNCT
dti-1318	450	1	babe	babe	NOUN
dti-1318	450	2	,	,	PUNCT
dti-1318	450	3	l.m	l.m	PROPN
dti-1318	450	4	.	.	PROPN
dti-1318	450	5	,	,	PUNCT
dti-1318	450	6	rose	rise	VERB
dti-1318	450	7	,	,	PUNCT
dti-1318	450	8	j.	j.	PROPN
dti-1318	450	9	and	and	CCONJ
dti-1318	450	10	craik	craik	PROPN
dti-1318	450	11	,	,	PUNCT
dti-1318	450	12	c.s	c.s	PROPN
dti-1318	450	13	.	.	PROPN
dti-1318	450	14	1992	1992	NUM
dti-1318	450	15	.	.	PUNCT
dti-1318	451	1	synthetic	synthetic	ADJ
dti-1318	451	2	“	"	PUNCT
dti-1318	451	3	interface	interface	NOUN
dti-1318	451	4	”	"	PUNCT
dti-1318	451	5	peptides	peptide	NOUN
dti-1318	451	6	alter	alter	VERB
dti-1318	451	7	dimeric	dimeric	ADJ
dti-1318	451	8	assembly	assembly	NOUN
dti-1318	451	9	of	of	ADP
dti-1318	451	10	the	the	DET
dti-1318	451	11	hiv	hiv	PROPN
dti-1318	451	12	1	1	NUM
dti-1318	451	13	and	and	CCONJ
dti-1318	451	14	2	2	NUM
dti-1318	451	15	proteases	protease	NOUN
dti-1318	451	16	.	.	PUNCT
dti-1318	452	1	protein	protein	NOUN
dti-1318	452	2	sci	sci	PROPN
dti-1318	452	3	.	.	PROPN
dti-1318	452	4	,	,	PUNCT
dti-1318	453	1	1:1244–1253	1:1244–1253	NUM
dti-1318	453	2	.	.	PUNCT
dti-1318	454	1	babe	babe	NOUN
dti-1318	454	2	,	,	PUNCT
dti-1318	454	3	l.m	l.m	PROPN
dti-1318	454	4	.	.	PROPN
dti-1318	454	5	,	,	PUNCT
dti-1318	454	6	rose	rise	VERB
dti-1318	454	7	,	,	PUNCT
dti-1318	454	8	j.	j.	PROPN
dti-1318	454	9	and	and	CCONJ
dti-1318	454	10	craik	craik	PROPN
dti-1318	454	11	,	,	PUNCT
dti-1318	454	12	c.s	c.s	PROPN
dti-1318	454	13	.	.	PROPN
dti-1318	454	14	1995	1995	NUM
dti-1318	454	15	.	.	PUNCT
dti-1318	455	1	trans	trans	ADJ
dti-1318	455	2	-	-	ADJ
dti-1318	455	3	dominant	dominant	ADJ
dti-1318	455	4	inhibitory	inhibitory	ADJ
dti-1318	455	5	human	human	ADJ
dti-1318	455	6	immunodefi	immunodefi	PROPN
dti-1318	455	7	ciency	ciency	NOUN
dti-1318	455	8	virus	virus	NOUN
dti-1318	455	9	type	type	NOUN
dti-1318	455	10	1	1	NUM
dti-1318	455	11	protease	protease	NOUN
dti-1318	455	12	monomers	monomer	NOUN
dti-1318	455	13	prevent	prevent	VERB
dti-1318	455	14	protease	protease	NOUN
dti-1318	455	15	activation	activation	NOUN
dti-1318	455	16	and	and	CCONJ
dti-1318	455	17	virion	virion	NOUN
dti-1318	455	18	maturation	maturation	NOUN
dti-1318	455	19	.	.	PUNCT
dti-1318	456	1	proc	proc	PROPN
dti-1318	456	2	.	.	PUNCT
dti-1318	457	1	natl	natl	PROPN
dti-1318	457	2	.	.	PUNCT
dti-1318	458	1	acad	acad	PROPN
dti-1318	458	2	.	.	PUNCT
dti-1318	459	1	sci	sci	PROPN
dti-1318	459	2	.	.	PUNCT
dti-1318	459	3	u.s.a	u.s.a	PROPN
dti-1318	459	4	.	.	PROPN
dti-1318	459	5	,	,	PUNCT
dti-1318	459	6	92:10069–10073	92:10069–10073	X
dti-1318	459	7	.	.	PUNCT
dti-1318	459	8	balzarini	balzarini	PROPN
dti-1318	459	9	,	,	PUNCT
dti-1318	459	10	j.	j.	PROPN
dti-1318	459	11	,	,	PUNCT
dti-1318	459	12	karlsson	karlsson	PROPN
dti-1318	459	13	,	,	PUNCT
dti-1318	459	14	a.	a.	PROPN
dti-1318	459	15	,	,	PUNCT
dti-1318	459	16	vandamme	vandamme	PROPN
dti-1318	459	17	,	,	PUNCT
dti-1318	459	18	a.m.	a.m.	ADV
dti-1318	459	19	,	,	PUNCT
dti-1318	459	20	perez	perez	PROPN
dti-1318	459	21	-	-	PUNCT
dti-1318	459	22	perez	perez	PROPN
dti-1318	459	23	,	,	PUNCT
dti-1318	459	24	m.j	m.j	PROPN
dti-1318	459	25	.	.	PROPN
dti-1318	459	26	,	,	PUNCT
dti-1318	459	27	zhang	zhang	PROPN
dti-1318	459	28	,	,	PUNCT
dti-1318	459	29	h.	h.	PROPN
dti-1318	459	30	,	,	PUNCT
dti-1318	459	31	vrang	vrang	PROPN
dti-1318	459	32	,	,	PUNCT
dti-1318	459	33	l.	l.	PROPN
dti-1318	459	34	,	,	PUNCT
dti-1318	459	35	oberg	oberg	PROPN
dti-1318	459	36	,	,	PUNCT
dti-1318	459	37	b.	b.	PROPN
dti-1318	459	38	,	,	PUNCT
dti-1318	459	39	backbro	backbro	NOUN
dti-1318	459	40	,	,	PUNCT
dti-1318	459	41	k.	k.	PROPN
dti-1318	459	42	,	,	PUNCT
dti-1318	459	43	unge	unge	PROPN
dti-1318	459	44	,	,	PUNCT
dti-1318	459	45	t.	t.	PROPN
dti-1318	459	46	,	,	PUNCT
dti-1318	459	47	san	san	PROPN
dti-1318	459	48	-	-	PUNCT
dti-1318	459	49	felix	felix	PROPN
dti-1318	459	50	,	,	PUNCT
dti-1318	459	51	a.	a.	PROPN
dti-1318	459	52	et	et	PROPN
dti-1318	459	53	al	al	PROPN
dti-1318	459	54	.	.	PROPN
dti-1318	459	55	1993	1993	NUM
dti-1318	459	56	.	.	PUNCT
dti-1318	460	1	human	human	ADJ
dti-1318	460	2	immunodefi	immunodefi	PROPN
dti-1318	460	3	ciency	ciency	NOUN
dti-1318	460	4	virus	virus	NOUN
dti-1318	460	5	type	type	NOUN
dti-1318	460	6	1	1	NUM
dti-1318	460	7	(	(	PUNCT
dti-1318	460	8	hiv-1	hiv-1	X
dti-1318	460	9	)	)	PUNCT
dti-1318	460	10	strains	strain	NOUN
dti-1318	460	11	selected	select	VERB
dti-1318	460	12	for	for	ADP
dti-1318	460	13	resistance	resistance	NOUN
dti-1318	460	14	against	against	ADP
dti-1318	460	15	the	the	DET
dti-1318	460	16	hiv-1	hiv-1	ADV
dti-1318	460	17	-	-	PUNCT
dti-1318	460	18	specific	specific	ADJ
dti-1318	460	19	[	[	X
dti-1318	460	20	2′,5′-bis	2′,5′-bis	NUM
dti-1318	460	21	-	-	NOUN
dti-1318	460	22	o-(tertbutyldimethylsilyl)-3′-spiro-5″-(4″-amino-1″,2″-oxathiole2″,2″-dioxide)]-beta	o-(tertbutyldimethylsilyl)-3′-spiro-5″-(4″-amino-1″,2″-oxathiole2″,2″-dioxide)]-beta	NUM
dti-1318	460	23	-	-	PUNCT
dti-1318	460	24	d	d	NOUN
dti-1318	460	25	-	-	PUNCT
dti-1318	460	26	pentofurano	pentofurano	ADJ
dti-1318	460	27	syl	syl	PROPN
dti-1318	460	28	(	(	PUNCT
dti-1318	460	29	tsao	tsao	NOUN
dti-1318	460	30	)	)	PUNCT
dti-1318	460	31	nucleoside	nucleoside	NOUN
dti-1318	460	32	analogues	analogue	NOUN
dti-1318	460	33	retain	retain	VERB
dti-1318	460	34	sensitivity	sensitivity	NOUN
dti-1318	460	35	to	to	ADP
dti-1318	460	36	hiv-1	hiv-1	NOUN
dti-1318	460	37	-	-	PUNCT
dti-1318	460	38	specifi	specifi	NOUN
dti-1318	460	39	c	c	PROPN
dti-1318	460	40	nonnucleoside	nonnucleoside	ADJ
dti-1318	460	41	inhibitors	inhibitor	NOUN
dti-1318	460	42	.	.	PUNCT
dti-1318	461	1	proc	proc	NOUN
dti-1318	461	2	.	.	PUNCT
dti-1318	462	1	natl	natl	PROPN
dti-1318	462	2	.	.	PUNCT
dti-1318	463	1	acad	acad	PROPN
dti-1318	463	2	.	.	PUNCT
dti-1318	464	1	sci	sci	PROPN
dti-1318	464	2	.	.	PUNCT
dti-1318	464	3	u.s.a	u.s.a	PROPN
dti-1318	464	4	.	.	PROPN
dti-1318	464	5	,	,	PUNCT
dti-1318	464	6	90:6952–6956	90:6952–6956	NUM
dti-1318	464	7	.	.	PUNCT
dti-1318	464	8	bannwarth	bannwarth	PROPN
dti-1318	464	9	,	,	PUNCT
dti-1318	464	10	l.	l.	PROPN
dti-1318	464	11	,	,	PUNCT
dti-1318	464	12	kessler	kessler	PROPN
dti-1318	464	13	,	,	PUNCT
dti-1318	464	14	a.	a.	PROPN
dti-1318	464	15	,	,	PUNCT
dti-1318	464	16	pethe	pethe	PROPN
dti-1318	464	17	,	,	PUNCT
dti-1318	464	18	s.	s.	PROPN
dti-1318	464	19	,	,	PUNCT
dti-1318	464	20	collinet	collinet	PROPN
dti-1318	464	21	,	,	PUNCT
dti-1318	464	22	b.	b.	PROPN
dti-1318	464	23	,	,	PUNCT
dti-1318	464	24	merabet	merabet	NOUN
dti-1318	464	25	,	,	PUNCT
dti-1318	464	26	n.	n.	NOUN
dti-1318	464	27	,	,	PUNCT
dti-1318	464	28	boggetto	boggetto	PROPN
dti-1318	464	29	,	,	PUNCT
dti-1318	464	30	n.	n.	NOUN
dti-1318	464	31	,	,	PUNCT
dti-1318	464	32	sicsic	sicsic	ADJ
dti-1318	464	33	,	,	PUNCT
dti-1318	464	34	s.	s.	PROPN
dti-1318	464	35	,	,	PUNCT
dti-1318	464	36	reboud	reboud	NOUN
dti-1318	464	37	-	-	PUNCT
dti-1318	464	38	ravaux	ravaux	NOUN
dti-1318	464	39	,	,	PUNCT
dti-1318	464	40	m.	m.	NOUN
dti-1318	464	41	and	and	CCONJ
dti-1318	464	42	ongeri	ongeri	NOUN
dti-1318	464	43	,	,	PUNCT
dti-1318	464	44	s.	s.	PROPN
dti-1318	464	45	2006	2006	NUM
dti-1318	464	46	.	.	PUNCT
dti-1318	465	1	molecular	molecular	ADJ
dti-1318	465	2	tongs	tong	NOUN
dti-1318	465	3	containing	contain	VERB
dti-1318	465	4	amino	amino	NOUN
dti-1318	465	5	acid	acid	NOUN
dti-1318	465	6	mimetic	mimetic	ADJ
dti-1318	465	7	fragments	fragment	NOUN
dti-1318	465	8	:	:	PUNCT
dti-1318	465	9	new	new	ADJ
dti-1318	465	10	inhibitors	inhibitor	NOUN
dti-1318	465	11	of	of	ADP
dti-1318	465	12	wildtype	wildtype	NOUN
dti-1318	465	13	and	and	CCONJ
dti-1318	465	14	mutated	mutate	VERB
dti-1318	465	15	hiv-1	hiv-1	X
dti-1318	465	16	protease	protease	NOUN
dti-1318	465	17	dimerization	dimerization	NOUN
dti-1318	465	18	.	.	PUNCT
dti-1318	466	1	j.	j.	PROPN
dti-1318	466	2	med	med	PROPN
dti-1318	466	3	.	.	PROPN
dti-1318	466	4	chem	chem	PROPN
dti-1318	466	5	.	.	PUNCT
dti-1318	466	6	,	,	PUNCT
dti-1318	466	7	49:4657–4664	49:4657–4664	NUM
dti-1318	466	8	.	.	PUNCT
dti-1318	467	1	bieniasz	bieniasz	PROPN
dti-1318	467	2	,	,	PUNCT
dti-1318	467	3	p.d	p.d	PROPN
dti-1318	467	4	.	.	PROPN
dti-1318	467	5	2006	2006	NUM
dti-1318	467	6	.	.	PUNCT
dti-1318	468	1	late	late	ADJ
dti-1318	468	2	budding	bud	VERB
dti-1318	468	3	domains	domain	NOUN
dti-1318	468	4	and	and	CCONJ
dti-1318	468	5	host	host	NOUN
dti-1318	468	6	proteins	protein	NOUN
dti-1318	468	7	in	in	ADP
dti-1318	468	8	enveloped	envelop	VERB
dti-1318	468	9	virus	virus	NOUN
dti-1318	468	10	release	release	NOUN
dti-1318	468	11	.	.	PUNCT
dti-1318	469	1	virology	virology	NOUN
dti-1318	469	2	,	,	PUNCT
dti-1318	469	3	344:55–63	344:55–63	NUM
dti-1318	469	4	.	.	PUNCT
dti-1318	469	5	binette	binette	PROPN
dti-1318	469	6	,	,	PUNCT
dti-1318	469	7	j.	j.	PROPN
dti-1318	469	8	and	and	CCONJ
dti-1318	469	9	cohen	cohen	PROPN
dti-1318	469	10	,	,	PUNCT
dti-1318	469	11	e.a	e.a	PROPN
dti-1318	469	12	.	.	PROPN
dti-1318	469	13	2004	2004	NUM
dti-1318	469	14	.	.	PUNCT
dti-1318	470	1	recent	recent	ADJ
dti-1318	470	2	advances	advance	NOUN
dti-1318	470	3	in	in	ADP
dti-1318	470	4	the	the	DET
dti-1318	470	5	understanding	understanding	NOUN
dti-1318	470	6	of	of	ADP
dti-1318	470	7	hiv-1	hiv-1	PUNCT
dti-1318	470	8	vpu	vpu	NOUN
dti-1318	470	9	accessory	accessory	ADJ
dti-1318	470	10	protein	protein	NOUN
dti-1318	470	11	functions	function	NOUN
dti-1318	470	12	.	.	PUNCT
dti-1318	471	1	curr	curr	PROPN
dti-1318	471	2	.	.	PUNCT
dti-1318	471	3	drug	drug	PROPN
dti-1318	471	4	.	.	PUNCT
dti-1318	472	1	targets	target	NOUN
dti-1318	472	2	immune	immune	ADJ
dti-1318	472	3	endocr	endocr	PROPN
dti-1318	472	4	.	.	PUNCT
dti-1318	473	1	metabol	metabol	PROPN
dti-1318	473	2	.	.	PUNCT
dti-1318	474	1	disord	disord	PROPN
dti-1318	474	2	.	.	PUNCT
dti-1318	474	3	,	,	PUNCT
dti-1318	474	4	4:297–307	4:297–307	NOUN
dti-1318	474	5	.	.	PUNCT
dti-1318	475	1	bouamr	bouamr	PROPN
dti-1318	475	2	,	,	PUNCT
dti-1318	475	3	f.	f.	PROPN
dti-1318	475	4	,	,	PUNCT
dti-1318	475	5	scarlata	scarlata	PROPN
dti-1318	475	6	,	,	PUNCT
dti-1318	475	7	s.	s.	PROPN
dti-1318	475	8	and	and	CCONJ
dti-1318	475	9	carter	carter	PROPN
dti-1318	475	10	,	,	PUNCT
dti-1318	475	11	c.	c.	PROPN
dti-1318	475	12	2003	2003	NUM
dti-1318	475	13	.	.	PUNCT
dti-1318	476	1	role	role	NOUN
dti-1318	476	2	of	of	ADP
dti-1318	476	3	myristylation	myristylation	NOUN
dti-1318	476	4	in	in	ADP
dti-1318	476	5	hiv-1	hiv-1	X
dti-1318	476	6	gag	gag	NOUN
dti-1318	476	7	assembly	assembly	NOUN
dti-1318	476	8	.	.	PUNCT
dti-1318	477	1	biochemistry	biochemistry	NOUN
dti-1318	477	2	,	,	PUNCT
dti-1318	477	3	42:6408–6417	42:6408–6417	NUM
dti-1318	477	4	.	.	PUNCT
dti-1318	477	5	bour	bour	PROPN
dti-1318	477	6	,	,	PUNCT
dti-1318	477	7	s.	s.	PROPN
dti-1318	477	8	and	and	CCONJ
dti-1318	477	9	strebel	strebel	PROPN
dti-1318	477	10	,	,	PUNCT
dti-1318	477	11	k.	k.	PROPN
dti-1318	477	12	2003	2003	NUM
dti-1318	477	13	.	.	PUNCT
dti-1318	478	1	the	the	DET
dti-1318	478	2	hiv-1	hiv-1	X
dti-1318	478	3	vpu	vpu	NOUN
dti-1318	478	4	protein	protein	NOUN
dti-1318	478	5	:	:	PUNCT
dti-1318	478	6	a	a	DET
dti-1318	478	7	multifunctional	multifunctional	ADJ
dti-1318	478	8	enhancer	enhancer	NOUN
dti-1318	478	9	of	of	ADP
dti-1318	478	10	viral	viral	ADJ
dti-1318	478	11	particle	particle	NOUN
dti-1318	478	12	release	release	NOUN
dti-1318	478	13	.	.	PUNCT
dti-1318	479	1	microbes	microbe	NOUN
dti-1318	479	2	infect	infect	VERB
dti-1318	479	3	.	.	PUNCT
dti-1318	479	4	,	,	PUNCT
dti-1318	479	5	5:1029–1039	5:1029–1039	NUM
dti-1318	479	6	.	.	PUNCT
dti-1318	480	1	bouras	boura	NOUN
dti-1318	480	2	,	,	PUNCT
dti-1318	480	3	a.	a.	NOUN
dti-1318	480	4	,	,	PUNCT
dti-1318	480	5	boggetto	boggetto	NOUN
dti-1318	480	6	,	,	PUNCT
dti-1318	480	7	n.	n.	PROPN
dti-1318	480	8	,	,	PUNCT
dti-1318	480	9	benatalah	benatalah	PROPN
dti-1318	480	10	,	,	PUNCT
dti-1318	480	11	z.	z.	PROPN
dti-1318	480	12	,	,	PUNCT
dti-1318	480	13	de	de	X
dti-1318	480	14	rosny	rosny	VERB
dti-1318	480	15	,	,	PUNCT
dti-1318	480	16	e.	e.	PROPN
dti-1318	480	17	,	,	PUNCT
dti-1318	480	18	sicsic	sicsic	ADJ
dti-1318	480	19	,	,	PUNCT
dti-1318	480	20	s.	s.	PROPN
dti-1318	480	21	and	and	CCONJ
dti-1318	480	22	reboudravaux	reboudravaux	PROPN
dti-1318	480	23	,	,	PUNCT
dti-1318	480	24	m.	m.	NOUN
dti-1318	480	25	1999	1999	NUM
dti-1318	480	26	.	.	PUNCT
dti-1318	481	1	design	design	NOUN
dti-1318	481	2	,	,	PUNCT
dti-1318	481	3	synthesis	synthesis	NOUN
dti-1318	481	4	,	,	PUNCT
dti-1318	481	5	and	and	CCONJ
dti-1318	481	6	evaluation	evaluation	NOUN
dti-1318	481	7	of	of	ADP
dti-1318	481	8	conformationally	conformationally	ADV
dti-1318	481	9	constrained	constrain	VERB
dti-1318	481	10	tongs	tong	NOUN
dti-1318	481	11	,	,	PUNCT
dti-1318	481	12	new	new	ADJ
dti-1318	481	13	inhibitors	inhibitor	NOUN
dti-1318	481	14	of	of	ADP
dti-1318	481	15	hiv-1	hiv-1	X
dti-1318	481	16	protease	protease	NOUN
dti-1318	481	17	dimerization	dimerization	NOUN
dti-1318	481	18	.	.	PUNCT
dti-1318	482	1	j.	j.	PROPN
dti-1318	482	2	med	med	PROPN
dti-1318	482	3	.	.	PROPN
dti-1318	482	4	chem	chem	PROPN
dti-1318	482	5	.	.	PUNCT
dti-1318	482	6	,	,	PUNCT
dti-1318	482	7	42:957–962	42:957–962	PROPN
dti-1318	482	8	.	.	PUNCT
dti-1318	483	1	breccia	breccia	PROPN
dti-1318	483	2	,	,	PUNCT
dti-1318	483	3	p.	p.	PROPN
dti-1318	483	4	,	,	PUNCT
dti-1318	483	5	boggetto	boggetto	PROPN
dti-1318	483	6	,	,	PUNCT
dti-1318	483	7	n.	n.	NOUN
dti-1318	483	8	,	,	PUNCT
dti-1318	483	9	perez	perez	PROPN
dti-1318	483	10	-	-	PUNCT
dti-1318	483	11	fernandez	fernandez	PROPN
dti-1318	483	12	,	,	PUNCT
dti-1318	483	13	r.	r.	PROPN
dti-1318	483	14	,	,	PUNCT
dti-1318	483	15	van	van	PROPN
dti-1318	483	16	gool	gool	PROPN
dti-1318	483	17	,	,	PUNCT
dti-1318	483	18	m.	m.	NOUN
dti-1318	483	19	,	,	PUNCT
dti-1318	483	20	takahashi	takahashi	PROPN
dti-1318	483	21	,	,	PUNCT
dti-1318	483	22	m.	m.	NOUN
dti-1318	483	23	,	,	PUNCT
dti-1318	483	24	rene	rene	PROPN
dti-1318	483	25	,	,	PUNCT
dti-1318	483	26	l.	l.	PROPN
dti-1318	483	27	,	,	PUNCT
dti-1318	483	28	prados	prado	NOUN
dti-1318	483	29	,	,	PUNCT
dti-1318	483	30	p.	p.	NOUN
dti-1318	483	31	,	,	PUNCT
dti-1318	483	32	badet	badet	PROPN
dti-1318	483	33	,	,	PUNCT
dti-1318	483	34	b.	b.	PROPN
dti-1318	483	35	,	,	PUNCT
dti-1318	483	36	reboud	reboud	PROPN
dti-1318	483	37	-	-	PUNCT
dti-1318	483	38	ravaux	ravaux	NOUN
dti-1318	483	39	,	,	PUNCT
dti-1318	483	40	m.	m.	NOUN
dti-1318	483	41	and	and	CCONJ
dti-1318	483	42	de	de	PROPN
dti-1318	483	43	mendoza	mendoza	PROPN
dti-1318	483	44	,	,	PUNCT
dti-1318	483	45	j.	j.	PROPN
dti-1318	483	46	2003	2003	NUM
dti-1318	483	47	.	.	PUNCT
dti-1318	484	1	dimerization	dimerization	NOUN
dti-1318	484	2	inhibitors	inhibitor	NOUN
dti-1318	484	3	of	of	ADP
dti-1318	484	4	hiv-1	hiv-1	X
dti-1318	484	5	protease	protease	NOUN
dti-1318	484	6	based	base	VERB
dti-1318	484	7	on	on	ADP
dti-1318	484	8	a	a	DET
dti-1318	484	9	bicyclic	bicyclic	NOUN
dti-1318	484	10	guanidinium	guanidinium	NOUN
dti-1318	484	11	subunit	subunit	NOUN
dti-1318	484	12	.	.	PUNCT
dti-1318	485	1	j.	j.	PROPN
dti-1318	485	2	med	med	PROPN
dti-1318	485	3	.	.	PROPN
dti-1318	485	4	chem	chem	PROPN
dti-1318	485	5	.	.	PUNCT
dti-1318	485	6	,	,	PUNCT
dti-1318	485	7	46:5196–5207	46:5196–5207	PROPN
dti-1318	485	8	.	.	PUNCT
dti-1318	485	9	brierley	brierley	PROPN
dti-1318	485	10	,	,	PUNCT
dti-1318	485	11	i.	i.	PROPN
dti-1318	485	12	and	and	CCONJ
dti-1318	485	13	dos	dos	PROPN
dti-1318	485	14	ramos	ramos	PROPN
dti-1318	485	15	,	,	PUNCT
dti-1318	485	16	f.j	f.j	PROPN
dti-1318	485	17	.	.	PROPN
dti-1318	485	18	2006	2006	NUM
dti-1318	485	19	.	.	PUNCT
dti-1318	486	1	programmed	program	VERB
dti-1318	486	2	ribosomal	ribosomal	NOUN
dti-1318	486	3	frameshifting	frameshifting	NOUN
dti-1318	486	4	in	in	ADP
dti-1318	486	5	hiv-1	hiv-1	PUNCT
dti-1318	486	6	and	and	CCONJ
dti-1318	486	7	the	the	DET
dti-1318	486	8	sars	sars	PROPN
dti-1318	486	9	-	-	PUNCT
dti-1318	486	10	cov	cov	PROPN
dti-1318	486	11	.	.	PUNCT
dti-1318	487	1	virus	virus	NOUN
dti-1318	487	2	res	re	NOUN
dti-1318	487	3	.	.	PROPN
dti-1318	487	4	,	,	PUNCT
dti-1318	487	5	119:29–42	119:29–42	NUM
dti-1318	487	6	.	.	PROPN
dti-1318	487	7	broglia	broglia	PROPN
dti-1318	487	8	,	,	PUNCT
dti-1318	487	9	r.a	r.a	PROPN
dti-1318	487	10	.	.	PROPN
dti-1318	487	11	,	,	PUNCT
dti-1318	487	12	provasi	provasi	PROPN
dti-1318	487	13	,	,	PUNCT
dti-1318	487	14	d.	d.	PROPN
dti-1318	487	15	,	,	PUNCT
dti-1318	487	16	vasile	vasile	NOUN
dti-1318	487	17	,	,	PUNCT
dti-1318	487	18	f.	f.	PROPN
dti-1318	487	19	,	,	PUNCT
dti-1318	487	20	ottolina	ottolina	PROPN
dti-1318	487	21	,	,	PUNCT
dti-1318	487	22	g.	g.	PROPN
dti-1318	487	23	,	,	PUNCT
dti-1318	487	24	longhi	longhi	PROPN
dti-1318	487	25	,	,	PUNCT
dti-1318	487	26	r.	r.	PROPN
dti-1318	487	27	and	and	CCONJ
dti-1318	487	28	tiana	tiana	PROPN
dti-1318	487	29	,	,	PUNCT
dti-1318	487	30	g.	g.	PROPN
dti-1318	487	31	2006	2006	NUM
dti-1318	487	32	.	.	PUNCT
dti-1318	488	1	a	a	DET
dti-1318	488	2	folding	fold	VERB
dti-1318	488	3	inhibitor	inhibitor	NOUN
dti-1318	488	4	of	of	ADP
dti-1318	488	5	the	the	DET
dti-1318	488	6	hiv-1	hiv-1	ADJ
dti-1318	488	7	protease	protease	NOUN
dti-1318	488	8	.	.	PUNCT
dti-1318	489	1	proteins	protein	NOUN
dti-1318	489	2	,	,	PUNCT
dti-1318	489	3	62:928–933	62:928–933	PROPN
dti-1318	489	4	.	.	PUNCT
dti-1318	490	1	broglia	broglia	PROPN
dti-1318	490	2	,	,	PUNCT
dti-1318	490	3	r.a	r.a	PROPN
dti-1318	490	4	.	.	PROPN
dti-1318	490	5	,	,	PUNCT
dti-1318	490	6	tiana	tiana	PROPN
dti-1318	490	7	,	,	PUNCT
dti-1318	490	8	g.	g.	PROPN
dti-1318	490	9	,	,	PUNCT
dti-1318	490	10	sutto	sutto	PROPN
dti-1318	490	11	,	,	PUNCT
dti-1318	490	12	l.	l.	PROPN
dti-1318	490	13	,	,	PUNCT
dti-1318	490	14	provasi	provasi	PROPN
dti-1318	490	15	,	,	PUNCT
dti-1318	490	16	d.	d.	PROPN
dti-1318	490	17	and	and	CCONJ
dti-1318	490	18	simona	simona	PROPN
dti-1318	490	19	,	,	PUNCT
dti-1318	490	20	f.	f.	PROPN
dti-1318	490	21	2005	2005	NUM
dti-1318	490	22	.	.	PUNCT
dti-1318	491	1	design	design	NOUN
dti-1318	491	2	of	of	ADP
dti-1318	491	3	hiv-1	hiv-1	X
dti-1318	491	4	-	-	PUNCT
dti-1318	491	5	pr	pr	NOUN
dti-1318	491	6	inhibitors	inhibitor	NOUN
dti-1318	491	7	that	that	PRON
dti-1318	491	8	do	do	AUX
dti-1318	491	9	not	not	PART
dti-1318	491	10	create	create	VERB
dti-1318	491	11	resistance	resistance	NOUN
dti-1318	491	12	:	:	PUNCT
dti-1318	491	13	blocking	block	VERB
dti-1318	491	14	the	the	DET
dti-1318	491	15	folding	folding	NOUN
dti-1318	491	16	of	of	ADP
dti-1318	491	17	single	single	ADJ
dti-1318	491	18	monomers	monomer	NOUN
dti-1318	491	19	.	.	PUNCT
dti-1318	492	1	protein	protein	NOUN
dti-1318	492	2	sci	sci	PROPN
dti-1318	492	3	.	.	PROPN
dti-1318	492	4	,	,	PUNCT
dti-1318	492	5	14:2668–2681	14:2668–2681	NUM
dti-1318	492	6	.	.	PUNCT
dti-1318	493	1	bryant	bryant	PROPN
dti-1318	493	2	,	,	PUNCT
dti-1318	493	3	m.	m.	NOUN
dti-1318	493	4	ratner	ratner	PROPN
dti-1318	493	5	,	,	PUNCT
dti-1318	493	6	l.	l.	PROPN
dti-1318	493	7	1990	1990	NUM
dti-1318	493	8	.	.	PUNCT
dti-1318	494	1	myristoylation	myristoylation	NOUN
dti-1318	494	2	-	-	PUNCT
dti-1318	494	3	dependent	dependent	ADJ
dti-1318	494	4	replication	replication	NOUN
dti-1318	494	5	and	and	CCONJ
dti-1318	494	6	assembly	assembly	NOUN
dti-1318	494	7	of	of	ADP
dti-1318	494	8	human	human	ADJ
dti-1318	494	9	immunodefi	immunodefi	PROPN
dti-1318	494	10	ciency	ciency	NOUN
dti-1318	494	11	virus	virus	NOUN
dti-1318	494	12	1	1	NUM
dti-1318	494	13	.	.	PUNCT
dti-1318	494	14	proc	proc	PROPN
dti-1318	494	15	.	.	PUNCT
dti-1318	495	1	natl	natl	PROPN
dti-1318	495	2	.	.	PUNCT
dti-1318	496	1	acad	acad	PROPN
dti-1318	496	2	.	.	PUNCT
dti-1318	497	1	sci	sci	PROPN
dti-1318	497	2	.	.	PROPN
dti-1318	497	3	u.s.a	u.s.a	PROPN
dti-1318	497	4	,	,	PUNCT
dti-1318	497	5	87:523–527	87:523–527	PROPN
dti-1318	497	6	.	.	PUNCT
dti-1318	498	1	bryant	bryant	PROPN
dti-1318	498	2	,	,	PUNCT
dti-1318	498	3	m.l	m.l	PROPN
dti-1318	498	4	.	.	PROPN
dti-1318	498	5	,	,	PUNCT
dti-1318	498	6	heuckeroth	heuckeroth	PROPN
dti-1318	498	7	,	,	PUNCT
dti-1318	498	8	r.o	r.o	PROPN
dti-1318	498	9	.	.	PROPN
dti-1318	498	10	,	,	PUNCT
dti-1318	498	11	kimata	kimata	PROPN
dti-1318	498	12	,	,	PUNCT
dti-1318	498	13	j.t	j.t	PROPN
dti-1318	498	14	.	.	PROPN
dti-1318	498	15	,	,	PUNCT
dti-1318	498	16	ratner	ratner	PROPN
dti-1318	498	17	,	,	PUNCT
dti-1318	498	18	l.	l.	PROPN
dti-1318	498	19	and	and	CCONJ
dti-1318	498	20	gordon	gordon	PROPN
dti-1318	498	21	,	,	PUNCT
dti-1318	498	22	j.i	j.i	PROPN
dti-1318	498	23	.	.	PROPN
dti-1318	498	24	1989	1989	NUM
dti-1318	498	25	.	.	PUNCT
dti-1318	499	1	replication	replication	NOUN
dti-1318	499	2	of	of	ADP
dti-1318	499	3	human	human	ADJ
dti-1318	499	4	immunodefi	immunodefi	PROPN
dti-1318	499	5	ciency	ciency	NOUN
dti-1318	499	6	virus	virus	NOUN
dti-1318	499	7	1	1	NUM
dti-1318	499	8	and	and	CCONJ
dti-1318	499	9	moloney	moloney	PROPN
dti-1318	499	10	murine	murine	PROPN
dti-1318	499	11	leukemia	leukemia	PROPN
dti-1318	499	12	virus	virus	NOUN
dti-1318	499	13	is	be	AUX
dti-1318	499	14	inhibited	inhibit	VERB
dti-1318	499	15	by	by	ADP
dti-1318	499	16	different	different	ADJ
dti-1318	499	17	heteroatom	heteroatom	NOUN
dti-1318	499	18	-	-	PUNCT
dti-1318	499	19	containing	contain	VERB
dti-1318	499	20	analogs	analog	NOUN
dti-1318	499	21	of	of	ADP
dti-1318	499	22	myristic	myristic	ADJ
dti-1318	499	23	acid	acid	NOUN
dti-1318	499	24	.	.	PUNCT
dti-1318	500	1	proc	proc	PROPN
dti-1318	500	2	.	.	PUNCT
dti-1318	501	1	natl	natl	PROPN
dti-1318	501	2	.	.	PUNCT
dti-1318	502	1	acad	acad	PROPN
dti-1318	502	2	sci	sci	PROPN
dti-1318	502	3	.	.	PROPN
dti-1318	502	4	u.s.a	u.s.a	PROPN
dti-1318	502	5	.	.	PROPN
dti-1318	502	6	,	,	PUNCT
dti-1318	502	7	86:8655	86:8655	NUM
dti-1318	502	8	–	–	PUNCT
dti-1318	502	9	8659	8659	NUM
dti-1318	502	10	.	.	PUNCT
dti-1318	503	1	bryant	bryant	PROPN
dti-1318	503	2	,	,	PUNCT
dti-1318	503	3	m.l	m.l	PROPN
dti-1318	503	4	.	.	PROPN
dti-1318	503	5	,	,	PUNCT
dti-1318	503	6	ratner	ratner	PROPN
dti-1318	503	7	,	,	PUNCT
dti-1318	503	8	l.	l.	PROPN
dti-1318	503	9	,	,	PUNCT
dti-1318	503	10	duronio	duronio	NOUN
dti-1318	503	11	,	,	PUNCT
dti-1318	503	12	r.j	r.j	PROPN
dti-1318	503	13	.	.	PROPN
dti-1318	503	14	,	,	PUNCT
dti-1318	503	15	kishore	kishore	PROPN
dti-1318	503	16	,	,	PUNCT
dti-1318	503	17	n.s	n.s	PROPN
dti-1318	503	18	.	.	PROPN
dti-1318	503	19	,	,	PUNCT
dti-1318	503	20	devadas	devadas	PROPN
dti-1318	503	21	,	,	PUNCT
dti-1318	503	22	b.	b.	PROPN
dti-1318	503	23	,	,	PUNCT
dti-1318	503	24	adams	adams	PROPN
dti-1318	503	25	,	,	PUNCT
dti-1318	503	26	s.p	s.p	PROPN
dti-1318	503	27	.	.	PROPN
dti-1318	503	28	and	and	CCONJ
dti-1318	503	29	gordon	gordon	PROPN
dti-1318	503	30	,	,	PUNCT
dti-1318	503	31	j.i	j.i	PROPN
dti-1318	503	32	.	.	PROPN
dti-1318	503	33	1991	1991	NUM
dti-1318	503	34	.	.	PUNCT
dti-1318	504	1	incorporation	incorporation	NOUN
dti-1318	504	2	of	of	ADP
dti-1318	504	3	12	12	NUM
dti-1318	504	4	-	-	PUNCT
dti-1318	504	5	methoxydodecanoate	methoxydodecanoate	NOUN
dti-1318	504	6	into	into	ADP
dti-1318	504	7	the	the	DET
dti-1318	504	8	human	human	ADJ
dti-1318	504	9	immunodefi	immunodefi	PROPN
dti-1318	504	10	ciency	ciency	NOUN
dti-1318	504	11	virus	virus	NOUN
dti-1318	504	12	1	1	NUM
dti-1318	504	13	gag	gag	NOUN
dti-1318	504	14	polyprotein	polyprotein	ADJ
dti-1318	504	15	precursor	precursor	NOUN
dti-1318	504	16	inhibits	inhibit	VERB
dti-1318	504	17	its	its	PRON
dti-1318	504	18	proteolytic	proteolytic	ADJ
dti-1318	504	19	processing	processing	NOUN
dti-1318	504	20	and	and	CCONJ
dti-1318	504	21	virus	virus	NOUN
dti-1318	504	22	production	production	NOUN
dti-1318	504	23	in	in	ADP
dti-1318	504	24	a	a	DET
dti-1318	504	25	chronically	chronically	ADV
dti-1318	504	26	infected	infect	VERB
dti-1318	504	27	human	human	ADJ
dti-1318	504	28	lymphoid	lymphoid	NOUN
dti-1318	504	29	cell	cell	NOUN
dti-1318	504	30	line	line	NOUN
dti-1318	504	31	.	.	PUNCT
dti-1318	505	1	proc	proc	PROPN
dti-1318	505	2	.	.	PUNCT
dti-1318	506	1	natl	natl	PROPN
dti-1318	506	2	.	.	PUNCT
dti-1318	507	1	acad	acad	PROPN
dti-1318	507	2	.	.	PUNCT
dti-1318	508	1	sci	sci	PROPN
dti-1318	508	2	.	.	PUNCT
dti-1318	508	3	u.s.a	u.s.a	PROPN
dti-1318	508	4	.	.	PROPN
dti-1318	508	5	,	,	PUNCT
dti-1318	508	6	88:2055–2059	88:2055–2059	PROPN
dti-1318	508	7	.	.	PUNCT
dti-1318	508	8	bukovsky	bukovsky	PROPN
dti-1318	508	9	,	,	PUNCT
dti-1318	508	10	a.	a.	NOUN
dti-1318	508	11	and	and	CCONJ
dti-1318	508	12	gottlinger	gottlinger	PROPN
dti-1318	508	13	,	,	PUNCT
dti-1318	508	14	h.	h.	PROPN
dti-1318	508	15	1996	1996	NUM
dti-1318	508	16	.	.	PUNCT
dti-1318	509	1	lack	lack	NOUN
dti-1318	509	2	of	of	ADP
dti-1318	509	3	integrase	integrase	NOUN
dti-1318	509	4	can	can	AUX
dti-1318	509	5	markedly	markedly	ADV
dti-1318	509	6	affect	affect	VERB
dti-1318	509	7	human	human	ADJ
dti-1318	509	8	immunodefi	immunodefi	PROPN
dti-1318	509	9	ciency	ciency	NOUN
dti-1318	509	10	virus	virus	NOUN
dti-1318	509	11	type	type	NOUN
dti-1318	509	12	1	1	NUM
dti-1318	509	13	particle	particle	NOUN
dti-1318	509	14	production	production	NOUN
dti-1318	509	15	in	in	ADP
dti-1318	509	16	the	the	DET
dti-1318	509	17	presence	presence	NOUN
dti-1318	509	18	of	of	ADP
dti-1318	509	19	an	an	DET
dti-1318	509	20	active	active	ADJ
dti-1318	509	21	viral	viral	ADJ
dti-1318	509	22	protease	protease	NOUN
dti-1318	509	23	.	.	PUNCT
dti-1318	510	1	j.	j.	PROPN
dti-1318	510	2	virol	virol	PROPN
dti-1318	510	3	.	.	PUNCT
dti-1318	510	4	,	,	PUNCT
dti-1318	510	5	70:6820–6825	70:6820–6825	X
dti-1318	510	6	.	.	PUNCT
dti-1318	511	1	cafl	cafl	NOUN
dti-1318	511	2	isch	isch	PROPN
dti-1318	511	3	,	,	PUNCT
dti-1318	511	4	a.	a.	NOUN
dti-1318	511	5	,	,	PUNCT
dti-1318	511	6	schramm	schramm	PROPN
dti-1318	511	7	,	,	PUNCT
dti-1318	511	8	h.j	h.j	PROPN
dti-1318	511	9	.	.	PROPN
dti-1318	511	10	and	and	CCONJ
dti-1318	511	11	karplus	karplus	PROPN
dti-1318	511	12	,	,	PUNCT
dti-1318	511	13	m.	m.	NOUN
dti-1318	511	14	2000	2000	NUM
dti-1318	511	15	.	.	PUNCT
dti-1318	512	1	design	design	NOUN
dti-1318	512	2	of	of	ADP
dti-1318	512	3	dimerization	dimerization	NOUN
dti-1318	512	4	inhibitors	inhibitor	NOUN
dti-1318	512	5	of	of	ADP
dti-1318	512	6	hiv-1	hiv-1	X
dti-1318	512	7	aspartic	aspartic	ADJ
dti-1318	512	8	proteinase	proteinase	NOUN
dti-1318	512	9	:	:	PUNCT
dti-1318	512	10	a	a	DET
dti-1318	512	11	computer	computer	NOUN
dti-1318	512	12	-	-	PUNCT
dti-1318	512	13	based	base	VERB
dti-1318	512	14	combinatorial	combinatorial	ADJ
dti-1318	512	15	approach	approach	NOUN
dti-1318	512	16	.	.	PUNCT
dti-1318	513	1	j.	j.	PROPN
dti-1318	513	2	comput	comput	PROPN
dti-1318	513	3	.	.	PUNCT
dti-1318	513	4	aided	aid	VERB
dti-1318	513	5	mol	mol	PROPN
dti-1318	513	6	.	.	PUNCT
dti-1318	514	1	des	des	PROPN
dti-1318	514	2	.	.	PROPN
dti-1318	514	3	,	,	PUNCT
dti-1318	514	4	14:161–179	14:161–179	PROPN
dti-1318	514	5	.	.	PUNCT
dti-1318	515	1	callahan	callahan	PROPN
dti-1318	515	2	,	,	PUNCT
dti-1318	515	3	m.a	m.a	PROPN
dti-1318	515	4	.	.	PROPN
dti-1318	515	5	,	,	PUNCT
dti-1318	515	6	handley	handley	PROPN
dti-1318	515	7	,	,	PUNCT
dti-1318	515	8	m.a	m.a	PROPN
dti-1318	515	9	.	.	PROPN
dti-1318	515	10	,	,	PUNCT
dti-1318	515	11	lee	lee	PROPN
dti-1318	515	12	,	,	PUNCT
dti-1318	515	13	y.h	y.h	PROPN
dti-1318	515	14	.	.	PROPN
dti-1318	515	15	,	,	PUNCT
dti-1318	515	16	talbot	talbot	PROPN
dti-1318	515	17	,	,	PUNCT
dti-1318	515	18	k.j	k.j	PROPN
dti-1318	515	19	.	.	PROPN
dti-1318	515	20	,	,	PUNCT
dti-1318	515	21	harper	harper	PROPN
dti-1318	515	22	,	,	PUNCT
dti-1318	515	23	j.w	j.w	PROPN
dti-1318	515	24	.	.	PROPN
dti-1318	515	25	and	and	CCONJ
dti-1318	515	26	panganiban	panganiban	PROPN
dti-1318	515	27	,	,	PUNCT
dti-1318	515	28	a.t	a.t	PROPN
dti-1318	515	29	.	.	PROPN
dti-1318	515	30	1998	1998	NUM
dti-1318	515	31	.	.	PUNCT
dti-1318	516	1	functional	functional	ADJ
dti-1318	516	2	interaction	interaction	NOUN
dti-1318	516	3	of	of	ADP
dti-1318	516	4	human	human	ADJ
dti-1318	516	5	immunodefi	immunodefi	PROPN
dti-1318	516	6	ciency	ciency	NOUN
dti-1318	516	7	virus	virus	NOUN
dti-1318	516	8	type	type	NOUN
dti-1318	516	9	1	1	NUM
dti-1318	516	10	vpu	vpu	NOUN
dti-1318	516	11	and	and	CCONJ
dti-1318	516	12	gag	gag	VERB
dti-1318	516	13	with	with	ADP
dti-1318	516	14	a	a	DET
dti-1318	516	15	novel	novel	ADJ
dti-1318	516	16	member	member	NOUN
dti-1318	516	17	of	of	ADP
dti-1318	516	18	the	the	DET
dti-1318	516	19	tetratricopeptide	tetratricopeptide	ADJ
dti-1318	516	20	repeat	repeat	NOUN
dti-1318	516	21	protein	protein	NOUN
dti-1318	516	22	family	family	NOUN
dti-1318	516	23	.	.	PUNCT
dti-1318	517	1	j.	j.	PROPN
dti-1318	517	2	virol	virol	PROPN
dti-1318	517	3	.	.	PUNCT
dti-1318	517	4	,	,	PUNCT
dti-1318	517	5	72:5189–5197	72:5189–5197	X
dti-1318	517	6	.	.	PUNCT
dti-1318	518	1	camarasa	camarasa	PROPN
dti-1318	518	2	,	,	PUNCT
dti-1318	518	3	m.j	m.j	PROPN
dti-1318	518	4	.	.	PROPN
dti-1318	518	5	,	,	PUNCT
dti-1318	518	6	velazquez	velazquez	PROPN
dti-1318	518	7	,	,	PUNCT
dti-1318	518	8	s.	s.	PROPN
dti-1318	518	9	,	,	PUNCT
dti-1318	518	10	san	san	PROPN
dti-1318	518	11	-	-	PUNCT
dti-1318	518	12	felix	felix	PROPN
dti-1318	518	13	,	,	PUNCT
dti-1318	518	14	a.	a.	NOUN
dti-1318	518	15	,	,	PUNCT
dti-1318	518	16	perez	perez	PROPN
dti-1318	518	17	-	-	PUNCT
dti-1318	518	18	perez	perez	PROPN
dti-1318	518	19	,	,	PUNCT
dti-1318	518	20	m.j	m.j	PROPN
dti-1318	518	21	.	.	PROPN
dti-1318	518	22	,	,	PUNCT
dti-1318	518	23	bonache	bonache	PROPN
dti-1318	518	24	,	,	PUNCT
dti-1318	518	25	m.c	m.c	PROPN
dti-1318	518	26	.	.	PROPN
dti-1318	518	27	and	and	CCONJ
dti-1318	518	28	de	de	ADP
dti-1318	518	29	castro	castro	PROPN
dti-1318	518	30	,	,	PUNCT
dti-1318	518	31	s.	s.	PROPN
dti-1318	518	32	2006	2006	NUM
dti-1318	518	33	.	.	PUNCT
dti-1318	519	1	tsao	tsao	PROPN
dti-1318	519	2	derivatives	derivative	NOUN
dti-1318	519	3	,	,	PUNCT
dti-1318	519	4	inhibitors	inhibitor	NOUN
dti-1318	519	5	of	of	ADP
dti-1318	519	6	hiv-1	hiv-1	X
dti-1318	519	7	reverse	reverse	ADJ
dti-1318	519	8	transcriptase	transcriptase	NOUN
dti-1318	519	9	dimerization	dimerization	NOUN
dti-1318	519	10	:	:	PUNCT
dti-1318	519	11	recent	recent	ADJ
dti-1318	519	12	progress	progress	NOUN
dti-1318	519	13	.	.	PUNCT
dti-1318	520	1	curr	curr	PROPN
dti-1318	520	2	.	.	PUNCT
dti-1318	521	1	pharm	pharm	PROPN
dti-1318	521	2	.	.	PUNCT
dti-1318	522	1	des	des	PROPN
dti-1318	522	2	.	.	PROPN
dti-1318	522	3	,	,	PUNCT
dti-1318	522	4	12:1895–1907	12:1895–1907	PROPN
dti-1318	522	5	.	.	PUNCT
dti-1318	523	1	campbell	campbell	PROPN
dti-1318	523	2	,	,	PUNCT
dti-1318	523	3	s.	s.	PROPN
dti-1318	523	4	and	and	CCONJ
dti-1318	523	5	vogt	vogt	PROPN
dti-1318	523	6	,	,	PUNCT
dti-1318	523	7	v.m	v.m	PROPN
dti-1318	523	8	.	.	PROPN
dti-1318	523	9	1995	1995	NUM
dti-1318	523	10	.	.	PUNCT
dti-1318	524	1	self	self	NOUN
dti-1318	524	2	-	-	PUNCT
dti-1318	524	3	assembly	assembly	NOUN
dti-1318	524	4	in	in	ADP
dti-1318	524	5	vitro	vitro	X
dti-1318	524	6	of	of	ADP
dti-1318	524	7	purifi	purifi	ADJ
dti-1318	524	8	ed	ed	PROPN
dti-1318	524	9	ca	ca	PROPN
dti-1318	524	10	-	-	PUNCT
dti-1318	524	11	nc	nc	NOUN
dti-1318	524	12	proteins	protein	NOUN
dti-1318	524	13	from	from	ADP
dti-1318	524	14	rous	rous	ADJ
dti-1318	524	15	sarcoma	sarcoma	NOUN
dti-1318	524	16	virus	virus	NOUN
dti-1318	524	17	and	and	CCONJ
dti-1318	524	18	human	human	ADJ
dti-1318	524	19	immunodefi	immunodefi	PROPN
dti-1318	524	20	ciency	ciency	NOUN
dti-1318	524	21	virus	virus	NOUN
dti-1318	524	22	type	type	NOUN
dti-1318	524	23	1	1	NUM
dti-1318	524	24	.	.	PUNCT
dti-1318	524	25	j.	j.	PROPN
dti-1318	524	26	virol	virol	PROPN
dti-1318	524	27	.	.	PUNCT
dti-1318	524	28	,	,	PUNCT
dti-1318	525	1	69:6487–6497	69:6487–6497	PROPN
dti-1318	525	2	.	.	PUNCT
dti-1318	526	1	campbell	campbell	PROPN
dti-1318	526	2	,	,	PUNCT
dti-1318	526	3	w.	w.	PROPN
dti-1318	526	4	,	,	PUNCT
dti-1318	526	5	kleiman	kleiman	PROPN
dti-1318	526	6	,	,	PUNCT
dti-1318	526	7	l.	l.	PROPN
dti-1318	526	8	,	,	PUNCT
dti-1318	526	9	barany	barany	PROPN
dti-1318	526	10	,	,	PUNCT
dti-1318	526	11	l.	l.	PROPN
dti-1318	526	12	,	,	PUNCT
dti-1318	526	13	li	li	PROPN
dti-1318	526	14	,	,	PUNCT
dti-1318	526	15	z.	z.	PROPN
dti-1318	526	16	,	,	PUNCT
dti-1318	526	17	khorchid	khorchid	PROPN
dti-1318	526	18	,	,	PUNCT
dti-1318	526	19	a.	a.	PROPN
dti-1318	526	20	,	,	PUNCT
dti-1318	526	21	fujita	fujita	PROPN
dti-1318	526	22	,	,	PUNCT
dti-1318	526	23	e.	e.	PROPN
dti-1318	526	24	,	,	PUNCT
dti-1318	526	25	okada	okada	PROPN
dti-1318	526	26	,	,	PUNCT
dti-1318	526	27	n.	n.	NOUN
dti-1318	526	28	and	and	CCONJ
dti-1318	526	29	okada	okada	PROPN
dti-1318	526	30	,	,	PUNCT
dti-1318	526	31	h.	h.	PROPN
dti-1318	526	32	2002	2002	NUM
dti-1318	526	33	.	.	PUNCT
dti-1318	527	1	a	a	DET
dti-1318	527	2	novel	novel	ADJ
dti-1318	527	3	genetic	genetic	ADJ
dti-1318	527	4	algorithm	algorithm	NOUN
dti-1318	527	5	for	for	ADP
dti-1318	527	6	designing	design	VERB
dti-1318	527	7	mimetic	mimetic	ADJ
dti-1318	527	8	peptides	peptide	NOUN
dti-1318	527	9	that	that	PRON
dti-1318	527	10	interfere	interfere	VERB
dti-1318	527	11	with	with	ADP
dti-1318	527	12	the	the	DET
dti-1318	527	13	function	function	NOUN
dti-1318	527	14	of	of	ADP
dti-1318	527	15	a	a	DET
dti-1318	527	16	target	target	NOUN
dti-1318	527	17	molecule	molecule	NOUN
dti-1318	527	18	.	.	PUNCT
dti-1318	528	1	microbiol	microbiol	PROPN
dti-1318	528	2	.	.	PUNCT
dti-1318	529	1	immunol	immunol	PROPN
dti-1318	529	2	.	.	PUNCT
dti-1318	529	3	,	,	PUNCT
dti-1318	530	1	46:211–215	46:211–215	X
dti-1318	530	2	.	.	PUNCT
dti-1318	531	1	cartas	carta	NOUN
dti-1318	531	2	,	,	PUNCT
dti-1318	531	3	m.	m.	NOUN
dti-1318	531	4	,	,	PUNCT
dti-1318	531	5	singh	singh	PROPN
dti-1318	531	6	,	,	PUNCT
dti-1318	531	7	s.p	s.p	PROPN
dti-1318	531	8	.	.	PROPN
dti-1318	531	9	,	,	PUNCT
dti-1318	531	10	serio	serio	PROPN
dti-1318	531	11	,	,	PUNCT
dti-1318	531	12	d.	d.	PROPN
dti-1318	531	13	,	,	PUNCT
dti-1318	531	14	rizvi	rizvi	PROPN
dti-1318	531	15	,	,	PUNCT
dti-1318	531	16	t.a	t.a	PROPN
dti-1318	531	17	.	.	PROPN
dti-1318	531	18	,	,	PUNCT
dti-1318	531	19	kalyanaraman	kalyanaraman	PROPN
dti-1318	531	20	,	,	PUNCT
dti-1318	531	21	v.s.	v.s.	ADJ
dti-1318	531	22	,	,	PUNCT
dti-1318	531	23	goldsmith	goldsmith	PROPN
dti-1318	531	24	,	,	PUNCT
dti-1318	531	25	c.s	c.s	PROPN
dti-1318	531	26	.	.	PROPN
dti-1318	531	27	,	,	PUNCT
dti-1318	531	28	zaki	zaki	PROPN
dti-1318	531	29	,	,	PUNCT
dti-1318	531	30	s.r	s.r	PROPN
dti-1318	531	31	.	.	PROPN
dti-1318	531	32	,	,	PUNCT
dti-1318	531	33	weber	weber	PROPN
dti-1318	531	34	,	,	PUNCT
dti-1318	531	35	i.t	i.t	PROPN
dti-1318	531	36	.	.	PROPN
dti-1318	531	37	and	and	CCONJ
dti-1318	531	38	srinivasan	srinivasan	NOUN
dti-1318	531	39	,	,	PUNCT
dti-1318	531	40	a.	a.	NOUN
dti-1318	531	41	2001	2001	NUM
dti-1318	531	42	.	.	PUNCT
dti-1318	532	1	intravirion	intravirion	NOUN
dti-1318	532	2	display	display	NOUN
dti-1318	532	3	of	of	ADP
dti-1318	532	4	a	a	DET
dti-1318	532	5	peptide	peptide	NOUN
dti-1318	532	6	corresponding	correspond	VERB
dti-1318	532	7	to	to	ADP
dti-1318	532	8	the	the	DET
dti-1318	532	9	dimer	dimer	ADJ
dti-1318	532	10	structure	structure	NOUN
dti-1318	532	11	of	of	ADP
dti-1318	532	12	protease	protease	NOUN
dti-1318	532	13	attenuates	attenuate	NOUN
dti-1318	532	14	hiv-1	hiv-1	PART
dti-1318	532	15	replication	replication	NOUN
dti-1318	532	16	.	.	PUNCT
dti-1318	533	1	dna	dna	PROPN
dti-1318	533	2	cell	cell	NOUN
dti-1318	533	3	biol	biol	PROPN
dti-1318	533	4	.	.	PUNCT
dti-1318	533	5	,	,	PUNCT
dti-1318	533	6	20:797–805	20:797–805	PROPN
dti-1318	533	7	.	.	PUNCT
dti-1318	534	1	cen	cen	PROPN
dti-1318	534	2	,	,	PUNCT
dti-1318	534	3	s.	s.	PROPN
dti-1318	534	4	,	,	PUNCT
dti-1318	534	5	niu	niu	PROPN
dti-1318	534	6	,	,	PUNCT
dti-1318	534	7	m.	m.	NOUN
dti-1318	534	8	,	,	PUNCT
dti-1318	534	9	saadatmand	saadatmand	PROPN
dti-1318	534	10	,	,	PUNCT
dti-1318	534	11	j.	j.	PROPN
dti-1318	534	12	,	,	PUNCT
dti-1318	534	13	guo	guo	PROPN
dti-1318	534	14	,	,	PUNCT
dti-1318	534	15	f.	f.	PROPN
dti-1318	534	16	,	,	PUNCT
dti-1318	534	17	huang	huang	PROPN
dti-1318	534	18	,	,	PUNCT
dti-1318	534	19	y.	y.	PROPN
dti-1318	534	20	,	,	PUNCT
dti-1318	534	21	nabel	nabel	NOUN
dti-1318	534	22	,	,	PUNCT
dti-1318	534	23	g.j	g.j	PROPN
dti-1318	534	24	.	.	PROPN
dti-1318	534	25	and	and	CCONJ
dti-1318	534	26	kleiman	kleiman	PROPN
dti-1318	534	27	,	,	PUNCT
dti-1318	534	28	l.	l.	PROPN
dti-1318	534	29	2004	2004	NUM
dti-1318	534	30	.	.	PUNCT
dti-1318	535	1	incorporation	incorporation	NOUN
dti-1318	535	2	of	of	ADP
dti-1318	535	3	pol	pol	NOUN
dti-1318	535	4	into	into	ADP
dti-1318	535	5	human	human	ADJ
dti-1318	535	6	immunodefi	immunodefi	PROPN
dti-1318	535	7	ciency	ciency	NOUN
dti-1318	535	8	virus	virus	NOUN
dti-1318	535	9	type	type	NOUN
dti-1318	535	10	1	1	NUM
dti-1318	535	11	gag	gag	NOUN
dti-1318	535	12	virus	virus	NOUN
dti-1318	535	13	-	-	PUNCT
dti-1318	535	14	like	like	ADJ
dti-1318	535	15	particles	particle	NOUN
dti-1318	535	16	occurs	occur	VERB
dti-1318	535	17	independently	independently	ADV
dti-1318	535	18	of	of	ADP
dti-1318	535	19	the	the	DET
dti-1318	535	20	upstream	upstream	ADJ
dti-1318	535	21	gag	gag	NOUN
dti-1318	535	22	domain	domain	NOUN
dti-1318	535	23	in	in	ADP
dti-1318	535	24	gag	gag	NOUN
dti-1318	535	25	-	-	PUNCT
dti-1318	535	26	pol	pol	NOUN
dti-1318	535	27	.	.	PUNCT
dti-1318	536	1	j.	j.	PROPN
dti-1318	536	2	virol	virol	PROPN
dti-1318	536	3	.	.	PUNCT
dti-1318	536	4	,	,	PUNCT
dti-1318	536	5	78:1042–1049	78:1042–1049	X
dti-1318	536	6	.	.	PUNCT
dti-1318	537	1	cheng	cheng	PROPN
dti-1318	537	2	,	,	PUNCT
dti-1318	537	3	y.s	y.s	PROPN
dti-1318	537	4	.	.	PROPN
dti-1318	537	5	,	,	PUNCT
dti-1318	537	6	yin	yin	PROPN
dti-1318	537	7	,	,	PUNCT
dti-1318	537	8	f.h	f.h	PROPN
dti-1318	537	9	.	.	PROPN
dti-1318	537	10	,	,	PUNCT
dti-1318	537	11	foundling	foundling	NOUN
dti-1318	537	12	,	,	PUNCT
dti-1318	537	13	s.	s.	PROPN
dti-1318	537	14	,	,	PUNCT
dti-1318	537	15	blomstrom	blomstrom	PROPN
dti-1318	537	16	,	,	PUNCT
dti-1318	537	17	d.	d.	PROPN
dti-1318	537	18	and	and	CCONJ
dti-1318	537	19	kettner	kettner	PROPN
dti-1318	537	20	,	,	PUNCT
dti-1318	537	21	c.a	c.a	PROPN
dti-1318	537	22	.	.	PROPN
dti-1318	537	23	1990	1990	NUM
dti-1318	537	24	.	.	PUNCT
dti-1318	538	1	stability	stability	NOUN
dti-1318	538	2	and	and	CCONJ
dti-1318	538	3	activity	activity	NOUN
dti-1318	538	4	of	of	ADP
dti-1318	538	5	human	human	ADJ
dti-1318	538	6	immunodefi	immunodefi	PROPN
dti-1318	538	7	ciency	ciency	NOUN
dti-1318	538	8	virus	virus	NOUN
dti-1318	538	9	protease	protease	NOUN
dti-1318	538	10	:	:	PUNCT
dti-1318	538	11	comparison	comparison	NOUN
dti-1318	538	12	of	of	ADP
dti-1318	538	13	the	the	DET
dti-1318	538	14	natural	natural	ADJ
dti-1318	538	15	dimer	dimer	NOUN
dti-1318	538	16	with	with	ADP
dti-1318	538	17	a	a	DET
dti-1318	538	18	homologous	homologous	ADJ
dti-1318	538	19	,	,	PUNCT
dti-1318	538	20	singlechain	singlechain	ADJ
dti-1318	538	21	tethered	tethered	ADJ
dti-1318	538	22	dimer	dimer	NOUN
dti-1318	538	23	.	.	PUNCT
dti-1318	539	1	proc	proc	NOUN
dti-1318	539	2	.	.	PUNCT
dti-1318	540	1	natl	natl	PROPN
dti-1318	540	2	.	.	PUNCT
dti-1318	541	1	acad	acad	PROPN
dti-1318	541	2	.	.	PUNCT
dti-1318	542	1	sci	sci	PROPN
dti-1318	542	2	.	.	PUNCT
dti-1318	542	3	u.s.a	u.s.a	PROPN
dti-1318	542	4	.	.	PROPN
dti-1318	542	5	,	,	PUNCT
dti-1318	542	6	87:9660–9664	87:9660–9664	NUM
dti-1318	542	7	.	.	PUNCT
dti-1318	543	1	cherry	cherry	PROPN
dti-1318	543	2	,	,	PUNCT
dti-1318	543	3	e.	e.	PROPN
dti-1318	543	4	,	,	PUNCT
dti-1318	543	5	liang	liang	PROPN
dti-1318	543	6	,	,	PUNCT
dti-1318	543	7	c.	c.	PROPN
dti-1318	543	8	,	,	PUNCT
dti-1318	543	9	rong	rong	PROPN
dti-1318	543	10	,	,	PUNCT
dti-1318	543	11	l.	l.	PROPN
dti-1318	543	12	,	,	PUNCT
dti-1318	543	13	quan	quan	PROPN
dti-1318	543	14	,	,	PUNCT
dti-1318	543	15	y.	y.	PROPN
dti-1318	543	16	,	,	PUNCT
dti-1318	543	17	inouye	inouye	PROPN
dti-1318	543	18	,	,	PUNCT
dti-1318	543	19	p.	p.	PROPN
dti-1318	543	20	,	,	PUNCT
dti-1318	543	21	li	li	PROPN
dti-1318	543	22	,	,	PUNCT
dti-1318	543	23	x.	x.	PROPN
dti-1318	543	24	,	,	PUNCT
dti-1318	543	25	morin	morin	PROPN
dti-1318	543	26	,	,	PUNCT
dti-1318	543	27	n.	n.	NOUN
dti-1318	543	28	,	,	PUNCT
dti-1318	543	29	kotler	kotler	NOUN
dti-1318	543	30	,	,	PUNCT
dti-1318	543	31	m.	m.	NOUN
dti-1318	543	32	and	and	CCONJ
dti-1318	543	33	wainberg	wainberg	PROPN
dti-1318	543	34	,	,	PUNCT
dti-1318	543	35	m.a	m.a	PROPN
dti-1318	543	36	.	.	PROPN
dti-1318	543	37	1998	1998	NUM
dti-1318	543	38	.	.	PUNCT
dti-1318	544	1	characterization	characterization	NOUN
dti-1318	544	2	of	of	ADP
dti-1318	544	3	human	human	ADJ
dti-1318	544	4	immunodefi	immunodefi	PROPN
dti-1318	544	5	ciency	ciency	NOUN
dti-1318	544	6	virus	virus	NOUN
dti-1318	544	7	type-1	type-1	PROPN
dti-1318	544	8	(	(	PUNCT
dti-1318	544	9	hiv-1	hiv-1	NUM
dti-1318	544	10	)	)	PUNCT
dti-1318	544	11	particles	particle	NOUN
dti-1318	544	12	that	that	PRON
dti-1318	544	13	express	express	VERB
dti-1318	544	14	protease	protease	NOUN
dti-1318	544	15	-	-	PUNCT
dti-1318	544	16	reverse	reverse	NOUN
dti-1318	544	17	transcriptase	transcriptase	NOUN
dti-1318	544	18	fusion	fusion	NOUN
dti-1318	544	19	proteins	protein	NOUN
dti-1318	544	20	.	.	PUNCT
dti-1318	545	1	j.	j.	PROPN
dti-1318	545	2	mol	mol	PROPN
dti-1318	545	3	.	.	PUNCT
dti-1318	546	1	biol	biol	PROPN
dti-1318	546	2	.	.	PUNCT
dti-1318	546	3	,	,	PUNCT
dti-1318	546	4	284	284	NUM
dti-1318	546	5	:	:	PUNCT
dti-1318	546	6	43–56	43–56	NUM
dti-1318	546	7	.	.	PUNCT
dti-1318	547	1	chien	chien	PROPN
dti-1318	547	2	,	,	PUNCT
dti-1318	547	3	a.i	a.i	PROPN
dti-1318	547	4	.	.	PROPN
dti-1318	547	5	,	,	PUNCT
dti-1318	547	6	liao	liao	PROPN
dti-1318	547	7	,	,	PUNCT
dti-1318	547	8	w.h	w.h	PROPN
dti-1318	547	9	.	.	PROPN
dti-1318	547	10	,	,	PUNCT
dti-1318	547	11	yang	yang	PROPN
dti-1318	547	12	,	,	PUNCT
dti-1318	547	13	d.m	d.m	PROPN
dti-1318	547	14	.	.	PROPN
dti-1318	547	15	and	and	CCONJ
dti-1318	547	16	wang	wang	PROPN
dti-1318	547	17	,	,	PUNCT
dti-1318	547	18	c.t	c.t	PROPN
dti-1318	547	19	.	.	PROPN
dti-1318	547	20	2006	2006	NUM
dti-1318	547	21	.	.	PUNCT
dti-1318	548	1	a	a	DET
dti-1318	548	2	domain	domain	NOUN
dti-1318	548	3	directly	directly	ADV
dti-1318	548	4	c	c	NOUN
dti-1318	548	5	-	-	PUNCT
dti-1318	548	6	terminal	terminal	ADJ
dti-1318	548	7	to	to	ADP
dti-1318	548	8	the	the	DET
dti-1318	548	9	major	major	ADJ
dti-1318	548	10	homology	homology	NOUN
dti-1318	548	11	region	region	NOUN
dti-1318	548	12	of	of	ADP
dti-1318	548	13	human	human	ADJ
dti-1318	548	14	immunodefi	immunodefi	PROPN
dti-1318	548	15	ciency	ciency	NOUN
dti-1318	548	16	t	t	PROPN
dti-1318	548	17	-	-	PUNCT
dti-1318	548	18	ype	ype	NOUN
dti-1318	548	19	1	1	NUM
dti-1318	548	20	capsid	capsid	NOUN
dti-1318	548	21	protein	protein	NOUN
dti-1318	548	22	plays	play	VERB
dti-1318	548	23	a	a	DET
dti-1318	548	24	crucial	crucial	ADJ
dti-1318	548	25	role	role	NOUN
dti-1318	548	26	in	in	ADP
dti-1318	548	27	directing	direct	VERB
dti-1318	548	28	both	both	DET
dti-1318	548	29	virus	virus	NOUN
dti-1318	548	30	assembly	assembly	NOUN
dti-1318	548	31	and	and	CCONJ
dti-1318	548	32	incorporation	incorporation	NOUN
dti-1318	548	33	of	of	ADP
dti-1318	548	34	gag	gag	NOUN
dti-1318	548	35	-	-	PUNCT
dti-1318	548	36	pol	pol	NOUN
dti-1318	548	37	.	.	PUNCT
dti-1318	549	1	virology	virology	NOUN
dti-1318	549	2	,	,	PUNCT
dti-1318	549	3	348:84–95	348:84–95	NUM
dti-1318	549	4	.	.	PUNCT
dti-1318	550	1	chiu	chiu	PROPN
dti-1318	550	2	,	,	PUNCT
dti-1318	550	3	h.c	h.c	PROPN
dti-1318	550	4	.	.	PROPN
dti-1318	550	5	,	,	PUNCT
dti-1318	550	6	yao	yao	PROPN
dti-1318	550	7	,	,	PUNCT
dti-1318	550	8	s.y	s.y	PROPN
dti-1318	550	9	.	.	PROPN
dti-1318	550	10	and	and	CCONJ
dti-1318	550	11	wang	wang	PROPN
dti-1318	550	12	,	,	PUNCT
dti-1318	550	13	c.t	c.t	PROPN
dti-1318	550	14	.	.	PROPN
dti-1318	550	15	2002	2002	NUM
dti-1318	550	16	.	.	PUNCT
dti-1318	551	1	coding	code	VERB
dti-1318	551	2	sequences	sequence	NOUN
dti-1318	551	3	upstream	upstream	NOUN
dti-1318	551	4	of	of	ADP
dti-1318	551	5	the	the	DET
dti-1318	551	6	human	human	ADJ
dti-1318	551	7	immunodefi	immunodefi	PROPN
dti-1318	551	8	ciency	ciency	NOUN
dti-1318	551	9	virus	virus	NOUN
dti-1318	551	10	type	type	NOUN
dti-1318	551	11	1	1	NUM
dti-1318	551	12	reverse	reverse	NOUN
dti-1318	551	13	transcriptase	transcriptase	NOUN
dti-1318	551	14	domain	domain	NOUN
dti-1318	551	15	in	in	ADP
dti-1318	551	16	gag	gag	NOUN
dti-1318	551	17	-	-	PUNCT
dti-1318	551	18	pol	pol	NOUN
dti-1318	551	19	are	be	AUX
dti-1318	551	20	not	not	PART
dti-1318	551	21	essential	essential	ADJ
dti-1318	551	22	for	for	ADP
dti-1318	551	23	incorporation	incorporation	NOUN
dti-1318	551	24	of	of	ADP
dti-1318	551	25	the	the	DET
dti-1318	551	26	pr160(gag	pr160(gag	ADJ
dti-1318	551	27	-	-	PUNCT
dti-1318	551	28	pol	pol	NOUN
dti-1318	551	29	)	)	PUNCT
dti-1318	551	30	into	into	ADP
dti-1318	551	31	virus	virus	NOUN
dti-1318	551	32	particles	particle	NOUN
dti-1318	551	33	.	.	PUNCT
dti-1318	552	1	j.	j.	PROPN
dti-1318	552	2	virol	virol	PROPN
dti-1318	552	3	.	.	PUNCT
dti-1318	552	4	,	,	PUNCT
dti-1318	553	1	76:3221–3231	76:3221–3231	X
dti-1318	553	2	.	.	PUNCT
dti-1318	553	3	clavel	clavel	PROPN
dti-1318	553	4	,	,	PUNCT
dti-1318	553	5	f.	f.	PROPN
dti-1318	553	6	and	and	CCONJ
dti-1318	553	7	hance	hance	PROPN
dti-1318	553	8	,	,	PUNCT
dti-1318	553	9	a.j	a.j	PROPN
dti-1318	553	10	.	.	PROPN
dti-1318	553	11	2004	2004	NUM
dti-1318	553	12	.	.	PUNCT
dti-1318	554	1	hiv	hiv	PROPN
dti-1318	554	2	drug	drug	PROPN
dti-1318	554	3	resistance	resistance	NOUN
dti-1318	554	4	.	.	PUNCT
dti-1318	555	1	n.	n.	PROPN
dti-1318	555	2	engl	engl	PROPN
dti-1318	555	3	.	.	PUNCT
dti-1318	556	1	j.	j.	PROPN
dti-1318	556	2	med	med	PROPN
dti-1318	556	3	.	.	PROPN
dti-1318	556	4	,	,	PUNCT
dti-1318	556	5	350	350	NUM
dti-1318	556	6	:	:	SYM
dti-1318	556	7	1023–1035	1023–1035	NUM
dti-1318	556	8	.	.	PUNCT
dti-1318	557	1	177	177	NUM
dti-1318	557	2	targeting	target	VERB
dti-1318	557	3	the	the	DET
dti-1318	557	4	late	late	ADJ
dti-1318	557	5	stages	stage	NOUN
dti-1318	557	6	of	of	ADP
dti-1318	557	7	hiv-1	hiv-1	X
dti-1318	557	8	replication	replication	NOUN
dti-1318	557	9	drug	drug	NOUN
dti-1318	557	10	target	target	NOUN
dti-1318	557	11	insights	insight	NOUN
dti-1318	557	12	2007	2007	NUM
dti-1318	557	13	:	:	PUNCT
dti-1318	557	14	2	2	NUM
dti-1318	557	15	cotelle	cotelle	NOUN
dti-1318	557	16	,	,	PUNCT
dti-1318	557	17	p.	p.	NOUN
dti-1318	557	18	2006	2006	NUM
dti-1318	557	19	.	.	PUNCT
dti-1318	558	1	patented	patent	VERB
dti-1318	558	2	hiv-1	hiv-1	X
dti-1318	558	3	integrase	integrase	NOUN
dti-1318	558	4	inhibitors	inhibitor	NOUN
dti-1318	558	5	(	(	PUNCT
dti-1318	558	6	1998–2005	1998–2005	NUM
dti-1318	558	7	)	)	PUNCT
dti-1318	558	8	.	.	PUNCT
dti-1318	559	1	recent	recent	ADJ
dti-1318	559	2	patents	patent	NOUN
dti-1318	559	3	on	on	ADP
dti-1318	559	4	anti	anti	ADJ
dti-1318	559	5	-	-	ADJ
dti-1318	559	6	infective	infective	ADJ
dti-1318	559	7	drug	drug	NOUN
dti-1318	559	8	discovery	discovery	NOUN
dti-1318	559	9	,	,	PUNCT
dti-1318	559	10	1:1–15	1:1–15	NUM
dti-1318	559	11	.	.	PUNCT
dti-1318	560	1	davis	davis	PROPN
dti-1318	560	2	,	,	PUNCT
dti-1318	560	3	d.a	d.a	PROPN
dti-1318	560	4	.	.	PROPN
dti-1318	560	5	,	,	PUNCT
dti-1318	560	6	brown	brown	PROPN
dti-1318	560	7	,	,	PUNCT
dti-1318	560	8	c.a	c.a	PROPN
dti-1318	560	9	.	.	PROPN
dti-1318	560	10	,	,	PUNCT
dti-1318	560	11	singer	singer	NOUN
dti-1318	560	12	,	,	PUNCT
dti-1318	560	13	k.e	k.e	PROPN
dti-1318	560	14	.	.	PROPN
dti-1318	560	15	,	,	PUNCT
dti-1318	560	16	wang	wang	PROPN
dti-1318	560	17	,	,	PUNCT
dti-1318	560	18	v.	v.	PROPN
dti-1318	560	19	,	,	PUNCT
dti-1318	560	20	kaufman	kaufman	PROPN
dti-1318	560	21	,	,	PUNCT
dti-1318	560	22	j.	j.	PROPN
dti-1318	560	23	,	,	PUNCT
dti-1318	560	24	stahl	stahl	PROPN
dti-1318	560	25	,	,	PUNCT
dti-1318	560	26	s.j	s.j	PROPN
dti-1318	560	27	.	.	PROPN
dti-1318	560	28	,	,	PUNCT
dti-1318	560	29	wingfi	wingfi	PROPN
dti-1318	560	30	eld	eld	PROPN
dti-1318	560	31	,	,	PUNCT
dti-1318	560	32	p.	p.	PROPN
dti-1318	560	33	,	,	PUNCT
dti-1318	560	34	maeda	maeda	PROPN
dti-1318	560	35	,	,	PUNCT
dti-1318	560	36	k.	k.	PROPN
dti-1318	560	37	,	,	PUNCT
dti-1318	560	38	harada	harada	PROPN
dti-1318	560	39	,	,	PUNCT
dti-1318	560	40	s.	s.	PROPN
dti-1318	560	41	,	,	PUNCT
dti-1318	560	42	yoshimura	yoshimura	PROPN
dti-1318	560	43	,	,	PUNCT
dti-1318	560	44	k.	k.	PROPN
dti-1318	560	45	,	,	PUNCT
dti-1318	560	46	et	et	PROPN
dti-1318	560	47	al	al	PROPN
dti-1318	560	48	.	.	PROPN
dti-1318	560	49	2006	2006	NUM
dti-1318	560	50	.	.	PUNCT
dti-1318	561	1	inhibition	inhibition	NOUN
dti-1318	561	2	of	of	ADP
dti-1318	561	3	hiv-1	hiv-1	X
dti-1318	561	4	replication	replication	NOUN
dti-1318	561	5	by	by	ADP
dti-1318	561	6	a	a	DET
dti-1318	561	7	peptide	peptide	ADJ
dti-1318	561	8	dimerization	dimerization	NOUN
dti-1318	561	9	inhibitor	inhibitor	NOUN
dti-1318	561	10	of	of	ADP
dti-1318	561	11	hiv-1	hiv-1	X
dti-1318	561	12	protease	protease	NOUN
dti-1318	561	13	.	.	PUNCT
dti-1318	562	1	antiviral	antiviral	ADJ
dti-1318	562	2	res	re	NOUN
dti-1318	562	3	.	.	PROPN
dti-1318	562	4	,	,	PUNCT
dti-1318	562	5	72:89–99	72:89–99	NUM
dti-1318	562	6	.	.	PUNCT
dti-1318	563	1	de	de	X
dti-1318	563	2	clercq	clercq	PROPN
dti-1318	563	3	,	,	PUNCT
dti-1318	563	4	e.	e.	PROPN
dti-1318	563	5	1998	1998	NUM
dti-1318	563	6	.	.	PUNCT
dti-1318	564	1	the	the	DET
dti-1318	564	2	role	role	NOUN
dti-1318	564	3	of	of	ADP
dti-1318	564	4	non	non	ADJ
dti-1318	564	5	-	-	ADJ
dti-1318	564	6	nucleoside	nucleoside	ADJ
dti-1318	564	7	reverse	reverse	ADJ
dti-1318	564	8	transcriptase	transcriptase	NOUN
dti-1318	564	9	inhibitors	inhibitor	NOUN
dti-1318	564	10	(	(	PUNCT
dti-1318	564	11	nnrtis	nnrtis	ADJ
dti-1318	564	12	)	)	PUNCT
dti-1318	564	13	in	in	ADP
dti-1318	564	14	the	the	DET
dti-1318	564	15	therapy	therapy	NOUN
dti-1318	564	16	of	of	ADP
dti-1318	564	17	hiv-1	hiv-1	X
dti-1318	564	18	infection	infection	NOUN
dti-1318	564	19	.	.	PUNCT
dti-1318	565	1	antiviral	antiviral	ADJ
dti-1318	565	2	res	re	NOUN
dti-1318	565	3	.	.	PUNCT
dti-1318	565	4	,	,	PUNCT
dti-1318	565	5	38:153–179	38:153–179	PROPN
dti-1318	565	6	.	.	PUNCT
dti-1318	566	1	debyser	debyser	PROPN
dti-1318	566	2	,	,	PUNCT
dti-1318	566	3	z.	z.	PROPN
dti-1318	566	4	and	and	CCONJ
dti-1318	566	5	de	de	PROPN
dti-1318	566	6	clercq	clercq	PROPN
dti-1318	566	7	,	,	PUNCT
dti-1318	566	8	e.	e.	PROPN
dti-1318	566	9	1996	1996	NUM
dti-1318	566	10	.	.	PUNCT
dti-1318	567	1	chemical	chemical	NOUN
dti-1318	567	2	crosslinking	crosslinking	NOUN
dti-1318	567	3	of	of	ADP
dti-1318	567	4	the	the	DET
dti-1318	567	5	subunits	subunit	NOUN
dti-1318	567	6	of	of	ADP
dti-1318	567	7	hiv-1	hiv-1	X
dti-1318	567	8	reverse	reverse	ADJ
dti-1318	567	9	transcriptase	transcriptase	NOUN
dti-1318	567	10	.	.	PUNCT
dti-1318	568	1	protein	protein	NOUN
dti-1318	568	2	sci	sci	PROPN
dti-1318	568	3	.	.	PROPN
dti-1318	568	4	,	,	PUNCT
dti-1318	568	5	5:278–286	5:278–286	PROPN
dti-1318	568	6	.	.	PUNCT
dti-1318	569	1	demirov	demirov	PROPN
dti-1318	569	2	,	,	PUNCT
dti-1318	569	3	d.g	d.g	PROPN
dti-1318	569	4	.	.	PROPN
dti-1318	569	5	,	,	PUNCT
dti-1318	569	6	ono	ono	PROPN
dti-1318	569	7	,	,	PUNCT
dti-1318	569	8	a.	a.	PROPN
dti-1318	569	9	,	,	PUNCT
dti-1318	569	10	orenstein	orenstein	PROPN
dti-1318	569	11	,	,	PUNCT
dti-1318	569	12	j.m	j.m	PROPN
dti-1318	569	13	.	.	PROPN
dti-1318	569	14	and	and	CCONJ
dti-1318	569	15	freed	free	VERB
dti-1318	569	16	,	,	PUNCT
dti-1318	569	17	e.o	e.o	PROPN
dti-1318	569	18	.	.	PROPN
dti-1318	569	19	2002	2002	NUM
dti-1318	569	20	.	.	PUNCT
dti-1318	570	1	overexpression	overexpression	NOUN
dti-1318	570	2	of	of	ADP
dti-1318	570	3	the	the	DET
dti-1318	570	4	n	n	CCONJ
dti-1318	570	5	-	-	PUNCT
dti-1318	570	6	terminal	terminal	ADJ
dti-1318	570	7	domain	domain	NOUN
dti-1318	570	8	of	of	ADP
dti-1318	570	9	tsg101	tsg101	PROPN
dti-1318	570	10	inhibits	inhibit	VERB
dti-1318	570	11	hiv-1	hiv-1	ADJ
dti-1318	570	12	budding	bud	VERB
dti-1318	570	13	by	by	ADP
dti-1318	570	14	blocking	block	VERB
dti-1318	570	15	late	late	ADJ
dti-1318	570	16	domain	domain	NOUN
dti-1318	570	17	function	function	NOUN
dti-1318	570	18	.	.	PUNCT
dti-1318	571	1	proc	proc	PROPN
dti-1318	571	2	.	.	PUNCT
dti-1318	572	1	natl	natl	PROPN
dti-1318	572	2	.	.	PUNCT
dti-1318	573	1	acad	acad	PROPN
dti-1318	573	2	.	.	PUNCT
dti-1318	574	1	sci	sci	PROPN
dti-1318	574	2	.	.	PUNCT
dti-1318	574	3	u.s.a	u.s.a	PROPN
dti-1318	574	4	.	.	PROPN
dti-1318	574	5	,	,	PUNCT
dti-1318	574	6	99	99	NUM
dti-1318	574	7	:	:	PUNCT
dti-1318	575	1	955–960	955–960	NUM
dti-1318	575	2	.	.	PUNCT
dti-1318	576	1	deora	deora	PROPN
dti-1318	576	2	,	,	PUNCT
dti-1318	576	3	a.	a.	NOUN
dti-1318	576	4	and	and	CCONJ
dti-1318	576	5	ratner	ratner	PROPN
dti-1318	576	6	,	,	PUNCT
dti-1318	576	7	l.	l.	PROPN
dti-1318	576	8	2001	2001	NUM
dti-1318	576	9	.	.	PUNCT
dti-1318	577	1	viral	viral	ADJ
dti-1318	577	2	protein	protein	NOUN
dti-1318	577	3	u	u	NOUN
dti-1318	577	4	(	(	PUNCT
dti-1318	577	5	vpu)-mediated	vpu)-mediate	VERB
dti-1318	577	6	enhancement	enhancement	NOUN
dti-1318	577	7	of	of	ADP
dti-1318	577	8	human	human	ADJ
dti-1318	577	9	immunodefi	immunodefi	PROPN
dti-1318	577	10	ciency	ciency	NOUN
dti-1318	577	11	virus	virus	NOUN
dti-1318	577	12	type	type	NOUN
dti-1318	577	13	1	1	NUM
dti-1318	577	14	particle	particle	NOUN
dti-1318	577	15	release	release	NOUN
dti-1318	577	16	depends	depend	VERB
dti-1318	577	17	on	on	ADP
dti-1318	577	18	the	the	DET
dti-1318	577	19	rate	rate	NOUN
dti-1318	577	20	of	of	ADP
dti-1318	577	21	cellular	cellular	ADJ
dti-1318	577	22	proliferation	proliferation	NOUN
dti-1318	577	23	.	.	PUNCT
dti-1318	578	1	j.	j.	PROPN
dti-1318	578	2	virol	virol	PROPN
dti-1318	578	3	.	.	PUNCT
dti-1318	578	4	,	,	PUNCT
dti-1318	579	1	75:6714–6718	75:6714–6718	NUM
dti-1318	579	2	.	.	PUNCT
dti-1318	580	1	depollier	depollier	NOUN
dti-1318	580	2	,	,	PUNCT
dti-1318	580	3	j.	j.	PROPN
dti-1318	580	4	,	,	PUNCT
dti-1318	580	5	hourdou	hourdou	PROPN
dti-1318	580	6	,	,	PUNCT
dti-1318	580	7	m.l	m.l	PROPN
dti-1318	580	8	.	.	PROPN
dti-1318	580	9	,	,	PUNCT
dti-1318	580	10	aldrian	aldrian	PROPN
dti-1318	580	11	-	-	PUNCT
dti-1318	580	12	herrada	herrada	PROPN
dti-1318	580	13	,	,	PUNCT
dti-1318	580	14	g.	g.	PROPN
dti-1318	580	15	,	,	PUNCT
dti-1318	580	16	rothwell	rothwell	PROPN
dti-1318	580	17	,	,	PUNCT
dti-1318	580	18	p.	p.	NOUN
dti-1318	580	19	,	,	PUNCT
dti-1318	580	20	restle	restle	NOUN
dti-1318	580	21	,	,	PUNCT
dti-1318	580	22	t.	t.	NOUN
dti-1318	580	23	and	and	CCONJ
dti-1318	580	24	divita	divita	PROPN
dti-1318	580	25	,	,	PUNCT
dti-1318	580	26	g.	g.	PROPN
dti-1318	580	27	2005	2005	NUM
dti-1318	580	28	.	.	PUNCT
dti-1318	581	1	insight	insight	NOUN
dti-1318	581	2	into	into	ADP
dti-1318	581	3	the	the	DET
dti-1318	581	4	mechanism	mechanism	NOUN
dti-1318	581	5	of	of	ADP
dti-1318	581	6	a	a	DET
dti-1318	581	7	peptide	peptide	ADJ
dti-1318	581	8	inhibitor	inhibitor	NOUN
dti-1318	581	9	of	of	ADP
dti-1318	581	10	hiv	hiv	PROPN
dti-1318	581	11	reverse	reverse	VERB
dti-1318	581	12	transcriptase	transcriptase	NOUN
dti-1318	581	13	dimerization	dimerization	NOUN
dti-1318	581	14	.	.	PUNCT
dti-1318	582	1	biochemistry	biochemistry	NOUN
dti-1318	582	2	,	,	PUNCT
dti-1318	582	3	44	44	NUM
dti-1318	582	4	:	:	SYM
dti-1318	582	5	1909–1918	1909–1918	NUM
dti-1318	582	6	.	.	PUNCT
dti-1318	582	7	dettenhofer	dettenhofer	PROPN
dti-1318	582	8	,	,	PUNCT
dti-1318	582	9	m.	m.	NOUN
dti-1318	582	10	and	and	CCONJ
dti-1318	582	11	yu	yu	PROPN
dti-1318	582	12	,	,	PUNCT
dti-1318	582	13	x.f	x.f	PROPN
dti-1318	582	14	.	.	PROPN
dti-1318	582	15	1999	1999	NUM
dti-1318	582	16	.	.	PUNCT
dti-1318	583	1	proline	proline	NOUN
dti-1318	583	2	residues	residue	NOUN
dti-1318	583	3	in	in	ADP
dti-1318	583	4	human	human	ADJ
dti-1318	583	5	immunodefi	immunodefi	PROPN
dti-1318	583	6	ciency	ciency	NOUN
dti-1318	583	7	virus	virus	NOUN
dti-1318	583	8	type	type	NOUN
dti-1318	583	9	1	1	NUM
dti-1318	583	10	p6(gag	p6(gag	NUM
dti-1318	583	11	)	)	PUNCT
dti-1318	583	12	exert	exert	VERB
dti-1318	583	13	a	a	DET
dti-1318	583	14	cell	cell	NOUN
dti-1318	583	15	type	type	NOUN
dti-1318	583	16	-	-	PUNCT
dti-1318	583	17	dependent	dependent	ADJ
dti-1318	583	18	effect	effect	NOUN
dti-1318	583	19	on	on	ADP
dti-1318	583	20	viral	viral	ADJ
dti-1318	583	21	replication	replication	NOUN
dti-1318	583	22	and	and	CCONJ
dti-1318	583	23	virion	virion	NOUN
dti-1318	583	24	incorporation	incorporation	NOUN
dti-1318	583	25	of	of	ADP
dti-1318	583	26	pol	pol	NOUN
dti-1318	583	27	proteins	protein	NOUN
dti-1318	583	28	.	.	PUNCT
dti-1318	584	1	j.	j.	PROPN
dti-1318	584	2	virol	virol	PROPN
dti-1318	584	3	.	.	PUNCT
dti-1318	584	4	,	,	PUNCT
dti-1318	585	1	73:4696–4704	73:4696–4704	X
dti-1318	585	2	.	.	PUNCT
dti-1318	585	3	devadas	devadas	PROPN
dti-1318	585	4	,	,	PUNCT
dti-1318	585	5	b.	b.	PROPN
dti-1318	585	6	,	,	PUNCT
dti-1318	585	7	lu	lu	PROPN
dti-1318	585	8	,	,	PUNCT
dti-1318	585	9	t.	t.	PROPN
dti-1318	585	10	,	,	PUNCT
dti-1318	585	11	katoh	katoh	PROPN
dti-1318	585	12	,	,	PUNCT
dti-1318	585	13	a.	a.	PROPN
dti-1318	585	14	,	,	PUNCT
dti-1318	585	15	kishore	kishore	PROPN
dti-1318	585	16	,	,	PUNCT
dti-1318	585	17	n.s	n.s	PROPN
dti-1318	585	18	.	.	PROPN
dti-1318	585	19	,	,	PUNCT
dti-1318	585	20	wade	wade	PROPN
dti-1318	585	21	,	,	PUNCT
dti-1318	585	22	a.c	a.c	PROPN
dti-1318	585	23	.	.	PROPN
dti-1318	585	24	,	,	PUNCT
dti-1318	585	25	mehta	mehta	PROPN
dti-1318	585	26	,	,	PUNCT
dti-1318	585	27	p.p	p.p	PROPN
dti-1318	585	28	.	.	PROPN
dti-1318	585	29	,	,	PUNCT
dti-1318	585	30	rudnick	rudnick	NOUN
dti-1318	585	31	,	,	PUNCT
dti-1318	585	32	d.a	d.a	PROPN
dti-1318	585	33	.	.	PROPN
dti-1318	585	34	,	,	PUNCT
dti-1318	585	35	bryant	bryant	PROPN
dti-1318	585	36	,	,	PUNCT
dti-1318	585	37	m.l	m.l	PROPN
dti-1318	585	38	.	.	PROPN
dti-1318	585	39	,	,	PUNCT
dti-1318	585	40	adams	adams	PROPN
dti-1318	585	41	,	,	PUNCT
dti-1318	585	42	s.p	s.p	PROPN
dti-1318	585	43	.	.	PROPN
dti-1318	585	44	,	,	PUNCT
dti-1318	585	45	li	li	PROPN
dti-1318	585	46	,	,	PUNCT
dti-1318	585	47	q.	q.	PROPN
dti-1318	585	48	et	et	PROPN
dti-1318	585	49	al	al	PROPN
dti-1318	585	50	.	.	PROPN
dti-1318	585	51	1992	1992	NUM
dti-1318	585	52	.	.	PUNCT
dti-1318	586	1	substrate	substrate	NOUN
dti-1318	586	2	specifi	specifi	PROPN
dti-1318	586	3	city	city	PROPN
dti-1318	586	4	of	of	ADP
dti-1318	586	5	saccharomyces	saccharomyce	NOUN
dti-1318	586	6	cerevisiae	cerevisiae	VERB
dti-1318	586	7	myristoyl	myristoyl	NOUN
dti-1318	586	8	-	-	PUNCT
dti-1318	586	9	coa	coa	NOUN
dti-1318	586	10	:	:	PUNCT
dti-1318	586	11	protein	protein	NOUN
dti-1318	586	12	n	n	CCONJ
dti-1318	586	13	-	-	PUNCT
dti-1318	586	14	myristoyltransferase	myristoyltransferase	NOUN
dti-1318	586	15	.	.	PUNCT
dti-1318	587	1	analysis	analysis	NOUN
dti-1318	587	2	of	of	ADP
dti-1318	587	3	fatty	fatty	NOUN
dti-1318	587	4	acid	acid	NOUN
dti-1318	587	5	analogs	analog	NOUN
dti-1318	587	6	containing	contain	VERB
dti-1318	587	7	carbonyl	carbonyl	NOUN
dti-1318	587	8	groups	group	NOUN
dti-1318	587	9	,	,	PUNCT
dti-1318	587	10	nitrogen	nitrogen	NOUN
dti-1318	587	11	heteroatoms	heteroatom	NOUN
dti-1318	587	12	,	,	PUNCT
dti-1318	587	13	and	and	CCONJ
dti-1318	587	14	nitrogen	nitrogen	NOUN
dti-1318	587	15	heterocycles	heterocycle	NOUN
dti-1318	587	16	in	in	ADP
dti-1318	587	17	an	an	DET
dti-1318	587	18	in	in	ADP
dti-1318	587	19	vitro	vitro	X
dti-1318	587	20	enzyme	enzyme	NOUN
dti-1318	587	21	assay	assay	NOUN
dti-1318	587	22	and	and	CCONJ
dti-1318	587	23	subsequent	subsequent	ADJ
dti-1318	587	24	identifi	identifi	PROPN
dti-1318	587	25	cation	cation	NOUN
dti-1318	587	26	of	of	ADP
dti-1318	587	27	inhibitors	inhibitor	NOUN
dti-1318	587	28	of	of	ADP
dti-1318	587	29	human	human	ADJ
dti-1318	587	30	immunodefi	immunodefi	PROPN
dti-1318	587	31	ciency	ciency	NOUN
dti-1318	587	32	virus	virus	NOUN
dti-1318	587	33	i	i	PRON
dti-1318	587	34	replication	replication	NOUN
dti-1318	587	35	.	.	PUNCT
dti-1318	588	1	j.	j.	PROPN
dti-1318	588	2	biol	biol	PROPN
dti-1318	588	3	.	.	PUNCT
dti-1318	589	1	chem	chem	PROPN
dti-1318	589	2	.	.	PUNCT
dti-1318	589	3	,	,	PUNCT
dti-1318	589	4	267	267	NUM
dti-1318	589	5	:	:	PUNCT
dti-1318	589	6	7224–7239	7224–7239	NUM
dti-1318	589	7	.	.	PUNCT
dti-1318	590	1	ding	ding	PROPN
dti-1318	590	2	,	,	PUNCT
dti-1318	590	3	l.	l.	PROPN
dti-1318	590	4	,	,	PUNCT
dti-1318	590	5	derdowski	derdowski	PROPN
dti-1318	590	6	,	,	PUNCT
dti-1318	590	7	a.	a.	PROPN
dti-1318	590	8	,	,	PUNCT
dti-1318	590	9	wang	wang	PROPN
dti-1318	590	10	,	,	PUNCT
dti-1318	590	11	j.j	j.j	PROPN
dti-1318	590	12	.	.	PROPN
dti-1318	590	13	and	and	CCONJ
dti-1318	590	14	spearman	spearman	NOUN
dti-1318	590	15	,	,	PUNCT
dti-1318	590	16	p.	p.	NOUN
dti-1318	590	17	2003	2003	NUM
dti-1318	590	18	.	.	PUNCT
dti-1318	591	1	independent	independent	ADJ
dti-1318	591	2	segregation	segregation	NOUN
dti-1318	591	3	of	of	ADP
dti-1318	591	4	human	human	ADJ
dti-1318	591	5	immunodefi	immunodefi	PROPN
dti-1318	591	6	ciency	ciency	NOUN
dti-1318	591	7	virus	virus	NOUN
dti-1318	591	8	type	type	NOUN
dti-1318	591	9	1	1	NUM
dti-1318	591	10	gag	gag	NOUN
dti-1318	591	11	protein	protein	NOUN
dti-1318	591	12	complexes	complex	NOUN
dti-1318	591	13	and	and	CCONJ
dti-1318	591	14	lipid	lipid	NOUN
dti-1318	591	15	rafts	raft	NOUN
dti-1318	591	16	.	.	PUNCT
dti-1318	592	1	j.	j.	PROPN
dti-1318	592	2	virol	virol	PROPN
dti-1318	592	3	.	.	PUNCT
dti-1318	592	4	,	,	PUNCT
dti-1318	593	1	77:1916–1926	77:1916–1926	X
dti-1318	593	2	.	.	PUNCT
dti-1318	594	1	divita	divita	PROPN
dti-1318	594	2	,	,	PUNCT
dti-1318	594	3	g.	g.	PROPN
dti-1318	594	4	,	,	PUNCT
dti-1318	594	5	restle	restle	NOUN
dti-1318	594	6	,	,	PUNCT
dti-1318	594	7	t.	t.	PROPN
dti-1318	594	8	,	,	PUNCT
dti-1318	594	9	goody	goody	NOUN
dti-1318	594	10	,	,	PUNCT
dti-1318	594	11	r.s	r.s	PROPN
dti-1318	594	12	.	.	PROPN
dti-1318	594	13	,	,	PUNCT
dti-1318	594	14	chermann	chermann	PROPN
dti-1318	594	15	,	,	PUNCT
dti-1318	594	16	j.c	j.c	PROPN
dti-1318	594	17	.	.	PROPN
dti-1318	594	18	and	and	CCONJ
dti-1318	594	19	baillon	baillon	PROPN
dti-1318	594	20	,	,	PUNCT
dti-1318	594	21	j.g	j.g	PROPN
dti-1318	594	22	.	.	PROPN
dti-1318	594	23	1994	1994	NUM
dti-1318	594	24	.	.	PUNCT
dti-1318	595	1	inhibition	inhibition	NOUN
dti-1318	595	2	of	of	ADP
dti-1318	595	3	human	human	ADJ
dti-1318	595	4	immunodefi	immunodefi	PROPN
dti-1318	595	5	ciency	ciency	NOUN
dti-1318	595	6	virus	virus	NOUN
dti-1318	595	7	type	type	NOUN
dti-1318	595	8	1	1	NUM
dti-1318	595	9	reverse	reverse	NOUN
dti-1318	595	10	transcriptase	transcriptase	NOUN
dti-1318	595	11	dimerization	dimerization	NOUN
dti-1318	595	12	using	use	VERB
dti-1318	595	13	synthetic	synthetic	ADJ
dti-1318	595	14	peptides	peptide	NOUN
dti-1318	595	15	derived	derive	VERB
dti-1318	595	16	from	from	ADP
dti-1318	595	17	the	the	DET
dti-1318	595	18	connection	connection	NOUN
dti-1318	595	19	domain	domain	NOUN
dti-1318	595	20	.	.	PUNCT
dti-1318	596	1	j.	j.	PROPN
dti-1318	596	2	biol	biol	PROPN
dti-1318	596	3	.	.	PUNCT
dti-1318	597	1	chem	chem	PROPN
dti-1318	597	2	.	.	PUNCT
dti-1318	597	3	,	,	PUNCT
dti-1318	598	1	269:13080–13083	269:13080–13083	X
dti-1318	598	2	.	.	PUNCT
dti-1318	599	1	dorfman	dorfman	PROPN
dti-1318	599	2	,	,	PUNCT
dti-1318	599	3	t.	t.	PROPN
dti-1318	599	4	,	,	PUNCT
dti-1318	599	5	bukovsky	bukovsky	NOUN
dti-1318	599	6	,	,	PUNCT
dti-1318	599	7	a.	a.	NOUN
dti-1318	599	8	,	,	PUNCT
dti-1318	599	9	ohagen	ohagen	PROPN
dti-1318	599	10	,	,	PUNCT
dti-1318	599	11	a.	a.	NOUN
dti-1318	599	12	,	,	PUNCT
dti-1318	599	13	hoglund	hoglund	PROPN
dti-1318	599	14	,	,	PUNCT
dti-1318	599	15	s.	s.	PROPN
dti-1318	599	16	and	and	CCONJ
dti-1318	599	17	gottlinger	gottlinger	PROPN
dti-1318	599	18	,	,	PUNCT
dti-1318	599	19	h.g	h.g	PROPN
dti-1318	599	20	.	.	PROPN
dti-1318	599	21	1994	1994	NUM
dti-1318	599	22	.	.	PUNCT
dti-1318	600	1	functional	functional	ADJ
dti-1318	600	2	domains	domain	NOUN
dti-1318	600	3	of	of	ADP
dti-1318	600	4	the	the	DET
dti-1318	600	5	capsid	capsid	ADJ
dti-1318	600	6	protein	protein	NOUN
dti-1318	600	7	of	of	ADP
dti-1318	600	8	human	human	ADJ
dti-1318	600	9	immunodefi	immunodefi	PROPN
dti-1318	600	10	ciency	ciency	NOUN
dti-1318	600	11	virus	virus	NOUN
dti-1318	600	12	type	type	NOUN
dti-1318	600	13	1	1	NUM
dti-1318	600	14	.	.	PUNCT
dti-1318	600	15	j.	j.	PROPN
dti-1318	600	16	virol	virol	PROPN
dti-1318	600	17	.	.	PUNCT
dti-1318	600	18	,	,	PUNCT
dti-1318	601	1	68:8180–8187	68:8180–8187	NOUN
dti-1318	601	2	.	.	PUNCT
dti-1318	602	1	dulude	dulude	PROPN
dti-1318	602	2	,	,	PUNCT
dti-1318	602	3	d.	d.	PROPN
dti-1318	602	4	,	,	PUNCT
dti-1318	602	5	berchiche	berchiche	PROPN
dti-1318	602	6	,	,	PUNCT
dti-1318	602	7	y.a	y.a	PROPN
dti-1318	602	8	.	.	PROPN
dti-1318	602	9	,	,	PUNCT
dti-1318	602	10	gendron	gendron	PROPN
dti-1318	602	11	,	,	PUNCT
dti-1318	602	12	k.	k.	PROPN
dti-1318	602	13	,	,	PUNCT
dti-1318	602	14	brakier	brakier	PROPN
dti-1318	602	15	-	-	PUNCT
dti-1318	602	16	gingras	gingras	PROPN
dti-1318	602	17	,	,	PUNCT
dti-1318	602	18	l.	l.	PROPN
dti-1318	602	19	and	and	CCONJ
dti-1318	602	20	heveker	heveker	PROPN
dti-1318	602	21	,	,	PUNCT
dti-1318	602	22	n.	n.	NOUN
dti-1318	602	23	2006	2006	NUM
dti-1318	602	24	.	.	PUNCT
dti-1318	603	1	decreasing	decrease	VERB
dti-1318	603	2	the	the	DET
dti-1318	603	3	frameshift	frameshift	NOUN
dti-1318	603	4	effi	effi	PROPN
dti-1318	603	5	ciency	ciency	NOUN
dti-1318	603	6	translates	translate	VERB
dti-1318	603	7	into	into	ADP
dti-1318	603	8	an	an	DET
dti-1318	603	9	equivalent	equivalent	ADJ
dti-1318	603	10	reduction	reduction	NOUN
dti-1318	603	11	of	of	ADP
dti-1318	603	12	the	the	DET
dti-1318	603	13	replication	replication	NOUN
dti-1318	603	14	of	of	ADP
dti-1318	603	15	the	the	DET
dti-1318	603	16	human	human	ADJ
dti-1318	603	17	immunodefi	immunodefi	PROPN
dti-1318	603	18	ciency	ciency	NOUN
dti-1318	603	19	virus	virus	NOUN
dti-1318	603	20	type	type	NOUN
dti-1318	603	21	1	1	NUM
dti-1318	603	22	.	.	PUNCT
dti-1318	603	23	virology	virology	NOUN
dti-1318	603	24	,	,	PUNCT
dti-1318	603	25	345:127–136	345:127–136	NUM
dti-1318	603	26	.	.	PUNCT
dti-1318	604	1	dumond	dumond	PROPN
dti-1318	604	2	,	,	PUNCT
dti-1318	604	3	j.	j.	PROPN
dti-1318	604	4	,	,	PUNCT
dti-1318	604	5	boggetto	boggetto	PROPN
dti-1318	604	6	,	,	PUNCT
dti-1318	604	7	n.	n.	NOUN
dti-1318	604	8	,	,	PUNCT
dti-1318	604	9	schramm	schramm	PROPN
dti-1318	604	10	,	,	PUNCT
dti-1318	604	11	h.j	h.j	PROPN
dti-1318	604	12	.	.	PROPN
dti-1318	604	13	,	,	PUNCT
dti-1318	604	14	schramm	schramm	PROPN
dti-1318	604	15	,	,	PUNCT
dti-1318	604	16	w.	w.	PROPN
dti-1318	604	17	,	,	PUNCT
dti-1318	604	18	takahashi	takahashi	PROPN
dti-1318	604	19	,	,	PUNCT
dti-1318	604	20	m.	m.	NOUN
dti-1318	604	21	and	and	CCONJ
dti-1318	604	22	reboud	reboud	NOUN
dti-1318	604	23	-	-	PUNCT
dti-1318	604	24	ravaux	ravaux	NOUN
dti-1318	604	25	,	,	PUNCT
dti-1318	604	26	m.	m.	NOUN
dti-1318	604	27	2003	2003	NUM
dti-1318	604	28	.	.	PUNCT
dti-1318	605	1	thyroxine	thyroxine	NOUN
dti-1318	605	2	-	-	PUNCT
dti-1318	605	3	derivatives	derivative	NOUN
dti-1318	605	4	of	of	ADP
dti-1318	605	5	lipopeptides	lipopeptide	NOUN
dti-1318	605	6	:	:	PUNCT
dti-1318	605	7	bifunctional	bifunctional	ADJ
dti-1318	605	8	dimerization	dimerization	NOUN
dti-1318	605	9	inhibitors	inhibitor	NOUN
dti-1318	605	10	of	of	ADP
dti-1318	605	11	human	human	ADJ
dti-1318	605	12	immunodefi	immunodefi	NOUN
dti-1318	605	13	ciency	ciency	NOUN
dti-1318	605	14	virus-1	virus-1	NOUN
dti-1318	605	15	protease	protease	NOUN
dti-1318	605	16	.	.	PUNCT
dti-1318	606	1	biochem	biochem	PROPN
dti-1318	606	2	.	.	PUNCT
dti-1318	607	1	pharmacol	pharmacol	PROPN
dti-1318	607	2	.	.	PROPN
dti-1318	607	3	,	,	PUNCT
dti-1318	607	4	65:1097–1102	65:1097–1102	NUM
dti-1318	607	5	.	.	PUNCT
dti-1318	608	1	engelman	engelman	PROPN
dti-1318	608	2	,	,	PUNCT
dti-1318	608	3	a.	a.	PROPN
dti-1318	608	4	,	,	PUNCT
dti-1318	608	5	englund	englund	PROPN
dti-1318	608	6	,	,	PUNCT
dti-1318	608	7	g.	g.	PROPN
dti-1318	608	8	,	,	PUNCT
dti-1318	608	9	orenstein	orenstein	PROPN
dti-1318	608	10	,	,	PUNCT
dti-1318	608	11	j.m	j.m	PROPN
dti-1318	608	12	.	.	PROPN
dti-1318	608	13	,	,	PUNCT
dti-1318	608	14	martin	martin	PROPN
dti-1318	608	15	,	,	PUNCT
dti-1318	608	16	m.a	m.a	PROPN
dti-1318	608	17	.	.	PROPN
dti-1318	608	18	and	and	CCONJ
dti-1318	608	19	craigie	craigie	PROPN
dti-1318	608	20	,	,	PUNCT
dti-1318	608	21	r.	r.	PROPN
dti-1318	608	22	1995	1995	NUM
dti-1318	608	23	.	.	PUNCT
dti-1318	609	1	multiple	multiple	ADJ
dti-1318	609	2	effects	effect	NOUN
dti-1318	609	3	of	of	ADP
dti-1318	609	4	mutations	mutation	NOUN
dti-1318	609	5	in	in	ADP
dti-1318	609	6	human	human	ADJ
dti-1318	609	7	immunodefi	immunodefi	PROPN
dti-1318	609	8	ciency	ciency	NOUN
dti-1318	609	9	virus	virus	NOUN
dti-1318	609	10	type	type	NOUN
dti-1318	609	11	1	1	NUM
dti-1318	609	12	integrase	integrase	NOUN
dti-1318	609	13	on	on	ADP
dti-1318	609	14	viral	viral	ADJ
dti-1318	609	15	replication	replication	NOUN
dti-1318	609	16	.	.	PUNCT
dti-1318	610	1	j.	j.	PROPN
dti-1318	610	2	virol	virol	PROPN
dti-1318	610	3	.	.	PUNCT
dti-1318	610	4	,	,	PUNCT
dti-1318	611	1	69:2729–2736	69:2729–2736	X
dti-1318	611	2	.	.	PUNCT
dti-1318	612	1	ewart	ewart	PROPN
dti-1318	612	2	,	,	PUNCT
dti-1318	612	3	g.d	g.d	PROPN
dti-1318	612	4	.	.	PROPN
dti-1318	612	5	,	,	PUNCT
dti-1318	612	6	mills	mill	NOUN
dti-1318	612	7	,	,	PUNCT
dti-1318	612	8	k.	k.	PROPN
dti-1318	612	9	,	,	PUNCT
dti-1318	612	10	cox	cox	PROPN
dti-1318	612	11	,	,	PUNCT
dti-1318	612	12	g.b	g.b	PROPN
dti-1318	612	13	.	.	PROPN
dti-1318	612	14	and	and	CCONJ
dti-1318	612	15	gage	gage	NOUN
dti-1318	612	16	,	,	PUNCT
dti-1318	612	17	p.w	p.w	PROPN
dti-1318	612	18	.	.	PROPN
dti-1318	612	19	2002	2002	NUM
dti-1318	612	20	.	.	PUNCT
dti-1318	613	1	amiloride	amiloride	ADJ
dti-1318	613	2	derivatives	derivative	NOUN
dti-1318	613	3	block	block	NOUN
dti-1318	613	4	ion	ion	NOUN
dti-1318	613	5	channel	channel	NOUN
dti-1318	613	6	activity	activity	NOUN
dti-1318	613	7	and	and	CCONJ
dti-1318	613	8	enhancement	enhancement	NOUN
dti-1318	613	9	of	of	ADP
dti-1318	613	10	virus	virus	NOUN
dti-1318	613	11	-	-	PUNCT
dti-1318	613	12	like	like	ADJ
dti-1318	613	13	particle	particle	NOUN
dti-1318	613	14	budding	budding	NOUN
dti-1318	613	15	caused	cause	VERB
dti-1318	613	16	by	by	ADP
dti-1318	613	17	hiv-1	hiv-1	X
dti-1318	613	18	protein	protein	NOUN
dti-1318	613	19	vpu	vpu	NOUN
dti-1318	613	20	.	.	PUNCT
dti-1318	614	1	eur	eur	PROPN
dti-1318	614	2	.	.	PUNCT
dti-1318	615	1	biophys	biophy	NOUN
dti-1318	615	2	.	.	PUNCT
dti-1318	616	1	j.	j.	PROPN
dti-1318	616	2	,	,	PUNCT
dti-1318	616	3	31	31	NUM
dti-1318	616	4	:	:	PUNCT
dti-1318	616	5	26–35	26–35	NUM
dti-1318	616	6	.	.	PUNCT
dti-1318	617	1	ewart	ewart	PROPN
dti-1318	617	2	,	,	PUNCT
dti-1318	617	3	g.d	g.d	PROPN
dti-1318	617	4	.	.	PROPN
dti-1318	617	5	,	,	PUNCT
dti-1318	617	6	nasr	nasr	PROPN
dti-1318	617	7	,	,	PUNCT
dti-1318	617	8	n.	n.	NOUN
dti-1318	617	9	,	,	PUNCT
dti-1318	617	10	naif	naif	NOUN
dti-1318	617	11	,	,	PUNCT
dti-1318	617	12	h.	h.	PROPN
dti-1318	617	13	,	,	PUNCT
dti-1318	617	14	cox	cox	PROPN
dti-1318	617	15	,	,	PUNCT
dti-1318	617	16	g.b	g.b	PROPN
dti-1318	617	17	.	.	PROPN
dti-1318	617	18	,	,	PUNCT
dti-1318	617	19	cunningham	cunningham	PROPN
dti-1318	617	20	,	,	PUNCT
dti-1318	617	21	a.l	a.l	PROPN
dti-1318	617	22	.	.	PROPN
dti-1318	617	23	and	and	CCONJ
dti-1318	617	24	gage	gage	NOUN
dti-1318	617	25	,	,	PUNCT
dti-1318	617	26	p.w	p.w	NOUN
dti-1318	617	27	.	.	PROPN
dti-1318	617	28	2004	2004	NUM
dti-1318	617	29	.	.	PUNCT
dti-1318	618	1	potential	potential	ADJ
dti-1318	618	2	new	new	ADJ
dti-1318	618	3	anti	anti	ADJ
dti-1318	618	4	-	-	ADJ
dti-1318	618	5	human	human	ADJ
dti-1318	618	6	immunodefi	immunodefi	ADJ
dti-1318	618	7	ciency	ciency	NOUN
dti-1318	618	8	virus	virus	NOUN
dti-1318	618	9	type	type	NOUN
dti-1318	618	10	1	1	NUM
dti-1318	618	11	compounds	compound	NOUN
dti-1318	618	12	depress	depress	VERB
dti-1318	618	13	virus	virus	NOUN
dti-1318	618	14	replication	replication	NOUN
dti-1318	618	15	in	in	ADP
dti-1318	618	16	cultured	cultured	ADJ
dti-1318	618	17	human	human	ADJ
dti-1318	618	18	macrophages	macrophage	NOUN
dti-1318	618	19	.	.	PUNCT
dti-1318	619	1	antimicrob	antimicrob	ADJ
dti-1318	619	2	.	.	PUNCT
dti-1318	620	1	agents	agents	PROPN
dti-1318	620	2	chemother	chemother	PROPN
dti-1318	620	3	.	.	PUNCT
dti-1318	620	4	,	,	PUNCT
dti-1318	620	5	48:2325–2330	48:2325–2330	PROPN
dti-1318	620	6	.	.	PUNCT
dti-1318	620	7	facke	facke	ADJ
dti-1318	620	8	,	,	PUNCT
dti-1318	620	9	m.	m.	NOUN
dti-1318	620	10	,	,	PUNCT
dti-1318	620	11	janetzko	janetzko	NOUN
dti-1318	620	12	,	,	PUNCT
dti-1318	620	13	a.	a.	NOUN
dti-1318	620	14	,	,	PUNCT
dti-1318	620	15	shoeman	shoeman	NOUN
dti-1318	620	16	,	,	PUNCT
dti-1318	620	17	r.l	r.l	PROPN
dti-1318	620	18	.	.	PROPN
dti-1318	620	19	and	and	CCONJ
dti-1318	620	20	krausslich	krausslich	PROPN
dti-1318	620	21	,	,	PUNCT
dti-1318	620	22	h.g	h.g	PROPN
dti-1318	620	23	.	.	PROPN
dti-1318	620	24	1993	1993	NUM
dti-1318	620	25	.	.	PUNCT
dti-1318	621	1	a	a	DET
dti-1318	621	2	large	large	ADJ
dti-1318	621	3	deletion	deletion	NOUN
dti-1318	621	4	in	in	ADP
dti-1318	621	5	the	the	DET
dti-1318	621	6	matrix	matrix	NOUN
dti-1318	621	7	domain	domain	NOUN
dti-1318	621	8	of	of	ADP
dti-1318	621	9	the	the	DET
dti-1318	621	10	human	human	ADJ
dti-1318	621	11	immunodefi	immunodefi	PROPN
dti-1318	621	12	ciency	ciency	NOUN
dti-1318	621	13	virus	virus	NOUN
dti-1318	621	14	gag	gag	NOUN
dti-1318	621	15	gene	gene	NOUN
dti-1318	621	16	redirects	redirect	VERB
dti-1318	621	17	virus	virus	NOUN
dti-1318	621	18	particle	particle	NOUN
dti-1318	621	19	assembly	assembly	NOUN
dti-1318	621	20	from	from	ADP
dti-1318	621	21	the	the	DET
dti-1318	621	22	plasma	plasma	NOUN
dti-1318	621	23	membrane	membrane	NOUN
dti-1318	621	24	to	to	ADP
dti-1318	621	25	the	the	DET
dti-1318	621	26	endoplasmic	endoplasmic	ADJ
dti-1318	621	27	reticulum	reticulum	NOUN
dti-1318	621	28	.	.	PUNCT
dti-1318	622	1	j.	j.	PROPN
dti-1318	622	2	virol	virol	PROPN
dti-1318	622	3	.	.	PUNCT
dti-1318	622	4	,	,	PUNCT
dti-1318	623	1	67:4972–4980	67:4972–4980	PROPN
dti-1318	623	2	.	.	PUNCT
dti-1318	624	1	fan	fan	PROPN
dti-1318	624	2	,	,	PUNCT
dti-1318	624	3	x.	x.	PROPN
dti-1318	624	4	,	,	PUNCT
dti-1318	624	5	flentke	flentke	PROPN
dti-1318	624	6	,	,	PUNCT
dti-1318	624	7	g.f	g.f	PROPN
dti-1318	624	8	.	.	PROPN
dti-1318	624	9	and	and	CCONJ
dti-1318	624	10	rich	rich	ADJ
dti-1318	624	11	,	,	PUNCT
dti-1318	624	12	d.h	d.h	PROPN
dti-1318	624	13	.	.	PROPN
dti-1318	624	14	1998	1998	NUM
dti-1318	624	15	.	.	PUNCT
dti-1318	625	1	inhibition	inhibition	NOUN
dti-1318	625	2	of	of	ADP
dti-1318	625	3	hiv-1	hiv-1	X
dti-1318	625	4	protease	protease	NOUN
dti-1318	625	5	by	by	ADP
dti-1318	625	6	a	a	DET
dti-1318	625	7	subunit	subunit	NOUN
dti-1318	625	8	of	of	ADP
dti-1318	625	9	didemnaketal	didemnaketal	ADJ
dti-1318	625	10	a.	a.	NOUN
dti-1318	625	11	journal	journal	PROPN
dti-1318	625	12	of	of	ADP
dti-1318	625	13	the	the	DET
dti-1318	625	14	american	american	PROPN
dti-1318	625	15	chemical	chemical	PROPN
dti-1318	625	16	society	society	PROPN
dti-1318	625	17	,	,	PUNCT
dti-1318	625	18	120:8893–8894	120:8893–8894	PROPN
dti-1318	625	19	.	.	PUNCT
dti-1318	625	20	figueiredo	figueiredo	PROPN
dti-1318	625	21	,	,	PUNCT
dti-1318	625	22	a.	a.	PROPN
dti-1318	625	23	,	,	PUNCT
dti-1318	625	24	moore	moore	PROPN
dti-1318	625	25	,	,	PUNCT
dti-1318	625	26	k.l	k.l	PROPN
dti-1318	625	27	.	.	PROPN
dti-1318	625	28	,	,	PUNCT
dti-1318	625	29	mak	mak	PROPN
dti-1318	625	30	,	,	PUNCT
dti-1318	625	31	j.	j.	PROPN
dti-1318	625	32	,	,	PUNCT
dti-1318	625	33	sluis	sluis	NOUN
dti-1318	625	34	-	-	PUNCT
dti-1318	625	35	cremer	cremer	NOUN
dti-1318	625	36	,	,	PUNCT
dti-1318	625	37	n.	n.	NOUN
dti-1318	625	38	,	,	PUNCT
dti-1318	625	39	de	de	PROPN
dti-1318	625	40	bethune	bethune	PROPN
dti-1318	625	41	,	,	PUNCT
dti-1318	625	42	m.p	m.p	PROPN
dti-1318	625	43	.	.	PROPN
dti-1318	625	44	and	and	CCONJ
dti-1318	625	45	tachedjian	tachedjian	NOUN
dti-1318	625	46	,	,	PUNCT
dti-1318	625	47	g.	g.	PROPN
dti-1318	625	48	2006	2006	NUM
dti-1318	625	49	.	.	PUNCT
dti-1318	626	1	potent	potent	ADJ
dti-1318	626	2	nonnucleoside	nonnucleoside	ADJ
dti-1318	626	3	reverse	reverse	ADJ
dti-1318	626	4	transcriptase	transcriptase	NOUN
dti-1318	626	5	inhibitors	inhibitor	NOUN
dti-1318	626	6	target	target	VERB
dti-1318	626	7	hiv-1	hiv-1	X
dti-1318	626	8	gag	gag	NOUN
dti-1318	626	9	-	-	PUNCT
dti-1318	626	10	pol	pol	NOUN
dti-1318	626	11	.	.	PUNCT
dti-1318	627	1	plos	plos	PROPN
dti-1318	627	2	pathog	pathog	PROPN
dti-1318	627	3	.	.	PUNCT
dti-1318	627	4	,	,	PUNCT
dti-1318	627	5	2	2	NUM
dti-1318	627	6	:	:	PUNCT
dti-1318	627	7	e119	e119	PROPN
dti-1318	627	8	.	.	NOUN
dti-1318	627	9	franciskovich	franciskovich	PROPN
dti-1318	627	10	,	,	PUNCT
dti-1318	627	11	j.	j.	PROPN
dti-1318	627	12	,	,	PUNCT
dti-1318	627	13	houseman	houseman	NOUN
dti-1318	627	14	,	,	PUNCT
dti-1318	627	15	k.	k.	PROPN
dti-1318	627	16	,	,	PUNCT
dti-1318	627	17	meuller	meuller	NOUN
dti-1318	627	18	,	,	PUNCT
dti-1318	627	19	r.	r.	PROPN
dti-1318	627	20	and	and	CCONJ
dti-1318	627	21	chmielewski	chmielewski	PROPN
dti-1318	627	22	,	,	PUNCT
dti-1318	627	23	j.	j.	PROPN
dti-1318	627	24	1993	1993	NUM
dti-1318	627	25	.	.	PUNCT
dti-1318	628	1	a	a	DET
dti-1318	628	2	systematic	systematic	ADJ
dti-1318	628	3	evaluation	evaluation	NOUN
dti-1318	628	4	of	of	ADP
dti-1318	628	5	the	the	DET
dti-1318	628	6	inhibition	inhibition	NOUN
dti-1318	628	7	of	of	ADP
dti-1318	628	8	hiv-1	hiv-1	PUNCT
dti-1318	628	9	protease	protease	NOUN
dti-1318	628	10	by	by	ADP
dti-1318	628	11	its	its	PRON
dti-1318	628	12	cand	cand	NOUN
dti-1318	628	13	n	n	CCONJ
dti-1318	628	14	-	-	PUNCT
dti-1318	628	15	terminal	terminal	ADJ
dti-1318	628	16	peptides	peptide	NOUN
dti-1318	628	17	.	.	PUNCT
dti-1318	629	1	bioorg	bioorg	PROPN
dti-1318	629	2	.	.	PUNCT
dti-1318	630	1	med	med	PROPN
dti-1318	630	2	.	.	PROPN
dti-1318	630	3	chem	chem	PROPN
dti-1318	630	4	.	.	PUNCT
dti-1318	631	1	lett	lett	PROPN
dti-1318	631	2	.	.	PROPN
dti-1318	631	3	,	,	PUNCT
dti-1318	631	4	765–768	765–768	NUM
dti-1318	631	5	.	.	PUNCT
dti-1318	632	1	freed	free	VERB
dti-1318	632	2	,	,	PUNCT
dti-1318	632	3	e.o	e.o	PROPN
dti-1318	632	4	.	.	PROPN
dti-1318	632	5	1998	1998	NUM
dti-1318	632	6	.	.	PUNCT
dti-1318	633	1	hiv-1	hiv-1	X
dti-1318	633	2	gag	gag	NOUN
dti-1318	633	3	proteins	protein	NOUN
dti-1318	633	4	:	:	PUNCT
dti-1318	633	5	diverse	diverse	ADJ
dti-1318	633	6	functions	function	NOUN
dti-1318	633	7	in	in	ADP
dti-1318	633	8	the	the	DET
dti-1318	633	9	virus	virus	NOUN
dti-1318	633	10	life	life	NOUN
dti-1318	633	11	cycle	cycle	NOUN
dti-1318	633	12	.	.	PUNCT
dti-1318	634	1	virology	virology	NOUN
dti-1318	634	2	,	,	PUNCT
dti-1318	634	3	251:1–15	251:1–15	NUM
dti-1318	634	4	.	.	PUNCT
dti-1318	635	1	gamble	gamble	NOUN
dti-1318	635	2	,	,	PUNCT
dti-1318	635	3	t.r	t.r	PROPN
dti-1318	635	4	.	.	PROPN
dti-1318	635	5	,	,	PUNCT
dti-1318	635	6	vajdos	vajdos	PROPN
dti-1318	635	7	,	,	PUNCT
dti-1318	635	8	f.f	f.f	PROPN
dti-1318	635	9	.	.	PROPN
dti-1318	635	10	,	,	PUNCT
dti-1318	635	11	yoo	yoo	PROPN
dti-1318	635	12	,	,	PUNCT
dti-1318	635	13	s.	s.	PROPN
dti-1318	635	14	,	,	PUNCT
dti-1318	635	15	worthylake	worthylake	NOUN
dti-1318	635	16	,	,	PUNCT
dti-1318	635	17	d.k	d.k	PROPN
dti-1318	635	18	.	.	PROPN
dti-1318	635	19	,	,	PUNCT
dti-1318	635	20	houseweart	houseweart	PROPN
dti-1318	635	21	,	,	PUNCT
dti-1318	635	22	m.	m.	NOUN
dti-1318	635	23	,	,	PUNCT
dti-1318	635	24	sundquist	sundquist	PROPN
dti-1318	635	25	,	,	PUNCT
dti-1318	635	26	w.i	w.i	PROPN
dti-1318	635	27	.	.	PROPN
dti-1318	635	28	and	and	CCONJ
dti-1318	635	29	hill	hill	PROPN
dti-1318	635	30	,	,	PUNCT
dti-1318	635	31	c.p	c.p	PROPN
dti-1318	635	32	.	.	PROPN
dti-1318	635	33	1996	1996	NUM
dti-1318	635	34	.	.	PUNCT
dti-1318	636	1	crystal	crystal	NOUN
dti-1318	636	2	structure	structure	NOUN
dti-1318	636	3	of	of	ADP
dti-1318	636	4	human	human	PROPN
dti-1318	636	5	cyclophilin	cyclophilin	PROPN
dti-1318	636	6	a	a	DET
dti-1318	636	7	bound	bind	VERB
dti-1318	636	8	to	to	ADP
dti-1318	636	9	the	the	DET
dti-1318	636	10	amino	amino	NOUN
dti-1318	636	11	-	-	PUNCT
dti-1318	636	12	terminal	terminal	ADJ
dti-1318	636	13	domain	domain	NOUN
dti-1318	636	14	of	of	ADP
dti-1318	636	15	hiv-1	hiv-1	X
dti-1318	636	16	capsid	capsid	ADJ
dti-1318	636	17	.	.	PUNCT
dti-1318	637	1	cell	cell	NOUN
dti-1318	637	2	,	,	PUNCT
dti-1318	637	3	87:1285–1294	87:1285–1294	NUM
dti-1318	637	4	.	.	PUNCT
dti-1318	638	1	gamble	gamble	NOUN
dti-1318	638	2	,	,	PUNCT
dti-1318	638	3	t.r	t.r	PROPN
dti-1318	638	4	.	.	PROPN
dti-1318	638	5	,	,	PUNCT
dti-1318	638	6	yoo	yoo	PROPN
dti-1318	638	7	,	,	PUNCT
dti-1318	638	8	s.	s.	PROPN
dti-1318	638	9	,	,	PUNCT
dti-1318	638	10	vajdos	vajdo	NOUN
dti-1318	638	11	,	,	PUNCT
dti-1318	638	12	f.f	f.f	PROPN
dti-1318	638	13	.	.	PROPN
dti-1318	638	14	,	,	PUNCT
dti-1318	638	15	von	von	PROPN
dti-1318	638	16	schwedler	schwedler	PROPN
dti-1318	638	17	,	,	PUNCT
dti-1318	638	18	u.k	u.k	PROPN
dti-1318	638	19	.	.	PROPN
dti-1318	638	20	,	,	PUNCT
dti-1318	638	21	worthylake	worthylake	NOUN
dti-1318	638	22	,	,	PUNCT
dti-1318	638	23	d.k	d.k	PROPN
dti-1318	638	24	.	.	PROPN
dti-1318	638	25	,	,	PUNCT
dti-1318	638	26	wang	wang	PROPN
dti-1318	638	27	,	,	PUNCT
dti-1318	638	28	h.	h.	PROPN
dti-1318	638	29	,	,	PUNCT
dti-1318	638	30	mccutcheon	mccutcheon	PROPN
dti-1318	638	31	,	,	PUNCT
dti-1318	638	32	j.p	j.p	PROPN
dti-1318	638	33	.	.	PROPN
dti-1318	638	34	,	,	PUNCT
dti-1318	638	35	sundquist	sundquist	PROPN
dti-1318	638	36	,	,	PUNCT
dti-1318	638	37	w.i	w.i	PROPN
dti-1318	638	38	.	.	PROPN
dti-1318	638	39	and	and	CCONJ
dti-1318	638	40	hill	hill	PROPN
dti-1318	638	41	,	,	PUNCT
dti-1318	638	42	c.p	c.p	PROPN
dti-1318	638	43	.	.	PROPN
dti-1318	638	44	1997	1997	NUM
dti-1318	638	45	.	.	PUNCT
dti-1318	639	1	structure	structure	NOUN
dti-1318	639	2	of	of	ADP
dti-1318	639	3	the	the	DET
dti-1318	639	4	carboxyl	carboxyl	NOUN
dti-1318	639	5	-	-	PUNCT
dti-1318	639	6	terminal	terminal	ADJ
dti-1318	639	7	dimerization	dimerization	NOUN
dti-1318	639	8	domain	domain	NOUN
dti-1318	639	9	of	of	ADP
dti-1318	639	10	the	the	DET
dti-1318	639	11	hiv1	hiv1	PROPN
dti-1318	639	12	capsid	capsid	PROPN
dti-1318	639	13	protein	protein	NOUN
dti-1318	639	14	.	.	PUNCT
dti-1318	640	1	science	science	NOUN
dti-1318	640	2	,	,	PUNCT
dti-1318	640	3	278:849–853	278:849–853	NUM
dti-1318	640	4	.	.	PUNCT
dti-1318	641	1	ganser	ganser	ADJ
dti-1318	641	2	-	-	PUNCT
dti-1318	641	3	pornillos	pornillos	ADJ
dti-1318	641	4	,	,	PUNCT
dti-1318	641	5	b.k	b.k	PROPN
dti-1318	641	6	.	.	PROPN
dti-1318	641	7	,	,	PUNCT
dti-1318	641	8	von	von	PROPN
dti-1318	641	9	schwedler	schwedler	PROPN
dti-1318	641	10	,	,	PUNCT
dti-1318	641	11	u.k	u.k	PROPN
dti-1318	641	12	.	.	PROPN
dti-1318	641	13	,	,	PUNCT
dti-1318	641	14	stray	stray	VERB
dti-1318	641	15	,	,	PUNCT
dti-1318	641	16	k.m	k.m	PROPN
dti-1318	641	17	.	.	PROPN
dti-1318	641	18	,	,	PUNCT
dti-1318	641	19	aiken	aiken	PROPN
dti-1318	641	20	,	,	PUNCT
dti-1318	641	21	c.	c.	PROPN
dti-1318	641	22	and	and	CCONJ
dti-1318	641	23	sundquist	sundquist	PROPN
dti-1318	641	24	,	,	PUNCT
dti-1318	641	25	w.i	w.i	PROPN
dti-1318	641	26	.	.	PROPN
dti-1318	641	27	2004	2004	NUM
dti-1318	641	28	.	.	PUNCT
dti-1318	642	1	assembly	assembly	NOUN
dti-1318	642	2	properties	property	NOUN
dti-1318	642	3	of	of	ADP
dti-1318	642	4	the	the	DET
dti-1318	642	5	human	human	ADJ
dti-1318	642	6	immunodefi	immunodefi	PROPN
dti-1318	642	7	ciency	ciency	NOUN
dti-1318	642	8	virus	virus	NOUN
dti-1318	642	9	type	type	NOUN
dti-1318	642	10	1	1	NUM
dti-1318	642	11	ca	ca	NOUN
dti-1318	642	12	protein	protein	NOUN
dti-1318	642	13	.	.	PUNCT
dti-1318	643	1	j.	j.	PROPN
dti-1318	643	2	virol	virol	PROPN
dti-1318	643	3	.	.	PUNCT
dti-1318	643	4	,	,	PUNCT
dti-1318	643	5	78:2545–2552	78:2545–2552	X
dti-1318	643	6	.	.	PUNCT
dti-1318	644	1	garrus	garrus	PROPN
dti-1318	644	2	,	,	PUNCT
dti-1318	644	3	j.e	j.e	PROPN
dti-1318	644	4	.	.	PROPN
dti-1318	644	5	,	,	PUNCT
dti-1318	644	6	von	von	PROPN
dti-1318	644	7	schwedler	schwedler	PROPN
dti-1318	644	8	,	,	PUNCT
dti-1318	644	9	u.k	u.k	PROPN
dti-1318	644	10	.	.	PROPN
dti-1318	644	11	,	,	PUNCT
dti-1318	644	12	pornillos	pornillo	NOUN
dti-1318	644	13	,	,	PUNCT
dti-1318	644	14	o.w	o.w	PROPN
dti-1318	644	15	.	.	PROPN
dti-1318	644	16	,	,	PUNCT
dti-1318	644	17	morham	morham	PROPN
dti-1318	644	18	,	,	PUNCT
dti-1318	644	19	s.g	s.g	PROPN
dti-1318	644	20	.	.	PROPN
dti-1318	644	21	,	,	PUNCT
dti-1318	644	22	zavitz	zavitz	PROPN
dti-1318	644	23	,	,	PUNCT
dti-1318	644	24	k.h	k.h	PROPN
dti-1318	644	25	.	.	PROPN
dti-1318	644	26	,	,	PUNCT
dti-1318	644	27	wang	wang	PROPN
dti-1318	644	28	,	,	PUNCT
dti-1318	644	29	h.e	h.e	PROPN
dti-1318	644	30	.	.	PROPN
dti-1318	644	31	,	,	PUNCT
dti-1318	644	32	wettstein	wettstein	PROPN
dti-1318	644	33	,	,	PUNCT
dti-1318	644	34	d.a	d.a	PROPN
dti-1318	644	35	.	.	PROPN
dti-1318	644	36	,	,	PUNCT
dti-1318	644	37	stray	stray	NOUN
dti-1318	644	38	,	,	PUNCT
dti-1318	644	39	k.m	k.m	PROPN
dti-1318	644	40	.	.	PROPN
dti-1318	644	41	,	,	PUNCT
dti-1318	644	42	cote	cote	PROPN
dti-1318	644	43	,	,	PUNCT
dti-1318	644	44	m.	m.	NOUN
dti-1318	644	45	,	,	PUNCT
dti-1318	644	46	rich	rich	ADJ
dti-1318	644	47	,	,	PUNCT
dti-1318	644	48	r.l	r.l	PROPN
dti-1318	644	49	.	.	PROPN
dti-1318	644	50	,	,	PUNCT
dti-1318	644	51	myszka	myszka	PROPN
dti-1318	644	52	,	,	PUNCT
dti-1318	644	53	d.g	d.g	PROPN
dti-1318	644	54	.	.	PROPN
dti-1318	644	55	and	and	CCONJ
dti-1318	644	56	sundquist	sundquist	PROPN
dti-1318	644	57	,	,	PUNCT
dti-1318	644	58	w.i	w.i	PROPN
dti-1318	644	59	.	.	PROPN
dti-1318	644	60	2001	2001	NUM
dti-1318	644	61	.	.	PUNCT
dti-1318	645	1	tsg101	tsg101	NOUN
dti-1318	645	2	and	and	CCONJ
dti-1318	645	3	the	the	DET
dti-1318	645	4	vacuolar	vacuolar	ADJ
dti-1318	645	5	protein	protein	NOUN
dti-1318	645	6	sorting	sort	VERB
dti-1318	645	7	pathway	pathway	NOUN
dti-1318	645	8	are	be	AUX
dti-1318	645	9	essential	essential	ADJ
dti-1318	645	10	for	for	ADP
dti-1318	645	11	hiv-1	hiv-1	VERB
dti-1318	645	12	budding	budding	NOUN
dti-1318	645	13	.	.	PUNCT
dti-1318	646	1	cell	cell	NOUN
dti-1318	646	2	,	,	PUNCT
dti-1318	646	3	107	107	NUM
dti-1318	646	4	:	:	SYM
dti-1318	646	5	55–65	55–65	NUM
dti-1318	646	6	.	.	PUNCT
dti-1318	647	1	gitti	gitti	PROPN
dti-1318	647	2	,	,	PUNCT
dti-1318	647	3	r.k	r.k	PROPN
dti-1318	647	4	.	.	PROPN
dti-1318	647	5	,	,	PUNCT
dti-1318	647	6	lee	lee	PROPN
dti-1318	647	7	,	,	PUNCT
dti-1318	647	8	b.m	b.m	PROPN
dti-1318	647	9	.	.	PROPN
dti-1318	647	10	,	,	PUNCT
dti-1318	647	11	walker	walker	PROPN
dti-1318	647	12	,	,	PUNCT
dti-1318	647	13	j.	j.	PROPN
dti-1318	647	14	,	,	PUNCT
dti-1318	647	15	summers	summer	NOUN
dti-1318	647	16	,	,	PUNCT
dti-1318	647	17	m.f	m.f	PROPN
dti-1318	647	18	.	.	PROPN
dti-1318	647	19	,	,	PUNCT
dti-1318	647	20	yoo	yoo	PROPN
dti-1318	647	21	,	,	PUNCT
dti-1318	647	22	s.	s.	PROPN
dti-1318	647	23	and	and	CCONJ
dti-1318	647	24	sundquist	sundquist	PROPN
dti-1318	647	25	,	,	PUNCT
dti-1318	647	26	w.i	w.i	PROPN
dti-1318	647	27	.	.	PROPN
dti-1318	647	28	1996	1996	NUM
dti-1318	647	29	.	.	PUNCT
dti-1318	648	1	structure	structure	NOUN
dti-1318	648	2	of	of	ADP
dti-1318	648	3	the	the	DET
dti-1318	648	4	amino	amino	NOUN
dti-1318	648	5	-	-	PUNCT
dti-1318	648	6	terminal	terminal	ADJ
dti-1318	648	7	core	core	NOUN
dti-1318	648	8	domain	domain	NOUN
dti-1318	648	9	of	of	ADP
dti-1318	648	10	the	the	DET
dti-1318	648	11	hiv1	hiv1	PROPN
dti-1318	648	12	capsid	capsid	PROPN
dti-1318	648	13	protein	protein	NOUN
dti-1318	648	14	.	.	PUNCT
dti-1318	649	1	science	science	NOUN
dti-1318	649	2	,	,	PUNCT
dti-1318	649	3	273:231–235	273:231–235	NUM
dti-1318	649	4	.	.	PUNCT
dti-1318	650	1	goila	goila	ADJ
dti-1318	650	2	-	-	PUNCT
dti-1318	650	3	gaur	gaur	NOUN
dti-1318	650	4	,	,	PUNCT
dti-1318	650	5	r.	r.	PROPN
dti-1318	650	6	,	,	PUNCT
dti-1318	650	7	demirov	demirov	PROPN
dti-1318	650	8	,	,	PUNCT
dti-1318	650	9	d.g	d.g	PROPN
dti-1318	650	10	.	.	PROPN
dti-1318	650	11	,	,	PUNCT
dti-1318	650	12	orenstein	orenstein	PROPN
dti-1318	650	13	,	,	PUNCT
dti-1318	650	14	j.m	j.m	PROPN
dti-1318	650	15	.	.	PROPN
dti-1318	650	16	,	,	PUNCT
dti-1318	650	17	ono	ono	PROPN
dti-1318	650	18	,	,	PUNCT
dti-1318	650	19	a.	a.	NOUN
dti-1318	650	20	and	and	CCONJ
dti-1318	650	21	freed	free	VERB
dti-1318	650	22	,	,	PUNCT
dti-1318	650	23	e.o	e.o	PROPN
dti-1318	650	24	.	.	PROPN
dti-1318	650	25	2003	2003	NUM
dti-1318	650	26	.	.	PUNCT
dti-1318	651	1	defects	defect	NOUN
dti-1318	651	2	in	in	ADP
dti-1318	651	3	human	human	ADJ
dti-1318	651	4	immunodefi	immunodefi	PROPN
dti-1318	651	5	ciency	ciency	NOUN
dti-1318	651	6	virus	virus	NOUN
dti-1318	651	7	budding	bud	VERB
dti-1318	651	8	and	and	CCONJ
dti-1318	651	9	endosomal	endosomal	ADJ
dti-1318	651	10	sorting	sorting	NOUN
dti-1318	651	11	induced	induce	VERB
dti-1318	651	12	by	by	ADP
dti-1318	651	13	tsg101	tsg101	PROPN
dti-1318	651	14	overexpression	overexpression	NOUN
dti-1318	651	15	.	.	PUNCT
dti-1318	652	1	j.	j.	PROPN
dti-1318	652	2	virol	virol	PROPN
dti-1318	652	3	.	.	PUNCT
dti-1318	652	4	,	,	PUNCT
dti-1318	652	5	77	77	NUM
dti-1318	652	6	:	:	PUNCT
dti-1318	652	7	6507–6519	6507–6519	NUM
dti-1318	652	8	.	.	PUNCT
dti-1318	653	1	gonzalez	gonzalez	PROPN
dti-1318	653	2	,	,	PUNCT
dti-1318	653	3	m.e	m.e	PROPN
dti-1318	653	4	.	.	PROPN
dti-1318	653	5	and	and	CCONJ
dti-1318	653	6	carrasco	carrasco	PROPN
dti-1318	653	7	,	,	PUNCT
dti-1318	653	8	l.	l.	PROPN
dti-1318	653	9	2003	2003	NUM
dti-1318	653	10	.	.	PUNCT
dti-1318	654	1	viroporins	viroporin	NOUN
dti-1318	654	2	.	.	PUNCT
dti-1318	655	1	febs	febs	PROPN
dti-1318	655	2	lett	lett	PROPN
dti-1318	655	3	.	.	PROPN
dti-1318	655	4	,	,	PUNCT
dti-1318	655	5	552:28–34	552:28–34	X
dti-1318	655	6	.	.	PUNCT
dti-1318	655	7	gottlinger	gottlinger	PROPN
dti-1318	655	8	,	,	PUNCT
dti-1318	655	9	h.g	h.g	PROPN
dti-1318	655	10	.	.	PROPN
dti-1318	655	11	,	,	PUNCT
dti-1318	655	12	dorfman	dorfman	PROPN
dti-1318	655	13	,	,	PUNCT
dti-1318	655	14	t.	t.	PROPN
dti-1318	655	15	,	,	PUNCT
dti-1318	655	16	sodroski	sodroski	ADJ
dti-1318	655	17	,	,	PUNCT
dti-1318	655	18	j.g	j.g	PROPN
dti-1318	655	19	.	.	PROPN
dti-1318	655	20	and	and	CCONJ
dti-1318	655	21	haseltine	haseltine	PROPN
dti-1318	655	22	,	,	PUNCT
dti-1318	655	23	w.a	w.a	PROPN
dti-1318	655	24	.	.	PROPN
dti-1318	655	25	1991	1991	NUM
dti-1318	655	26	.	.	PUNCT
dti-1318	656	1	effect	effect	NOUN
dti-1318	656	2	of	of	ADP
dti-1318	656	3	mutations	mutation	NOUN
dti-1318	656	4	affecting	affect	VERB
dti-1318	656	5	the	the	DET
dti-1318	656	6	p6	p6	ADJ
dti-1318	656	7	gag	gag	NOUN
dti-1318	656	8	protein	protein	NOUN
dti-1318	656	9	on	on	ADP
dti-1318	656	10	human	human	ADJ
dti-1318	656	11	immunodefi	immunodefi	PROPN
dti-1318	656	12	ciency	ciency	NOUN
dti-1318	656	13	virus	virus	NOUN
dti-1318	656	14	particle	particle	NOUN
dti-1318	656	15	release	release	NOUN
dti-1318	656	16	.	.	PUNCT
dti-1318	657	1	proc	proc	PROPN
dti-1318	657	2	.	.	PUNCT
dti-1318	658	1	natl	natl	PROPN
dti-1318	658	2	.	.	PUNCT
dti-1318	659	1	acad	acad	PROPN
dti-1318	659	2	.	.	PUNCT
dti-1318	660	1	sci	sci	PROPN
dti-1318	660	2	.	.	PUNCT
dti-1318	660	3	u.s.a	u.s.a	PROPN
dti-1318	660	4	.	.	PROPN
dti-1318	660	5	,	,	PUNCT
dti-1318	660	6	88	88	NUM
dti-1318	660	7	:	:	SYM
dti-1318	660	8	3195–3199	3195–3199	NUM
dti-1318	660	9	.	.	PUNCT
dti-1318	661	1	gottlinger	gottlinger	PROPN
dti-1318	661	2	,	,	PUNCT
dti-1318	661	3	h.g	h.g	PROPN
dti-1318	661	4	.	.	PROPN
dti-1318	661	5	,	,	PUNCT
dti-1318	661	6	sodroski	sodroski	PROPN
dti-1318	661	7	,	,	PUNCT
dti-1318	661	8	j.g	j.g	PROPN
dti-1318	661	9	.	.	PROPN
dti-1318	661	10	and	and	CCONJ
dti-1318	661	11	haseltine	haseltine	PROPN
dti-1318	661	12	,	,	PUNCT
dti-1318	661	13	w.a	w.a	PROPN
dti-1318	661	14	.	.	PROPN
dti-1318	661	15	1989	1989	NUM
dti-1318	661	16	.	.	PUNCT
dti-1318	662	1	role	role	NOUN
dti-1318	662	2	of	of	ADP
dti-1318	662	3	capsid	capsid	ADJ
dti-1318	662	4	precursor	precursor	NOUN
dti-1318	662	5	processing	processing	NOUN
dti-1318	662	6	and	and	CCONJ
dti-1318	662	7	myristoylation	myristoylation	NOUN
dti-1318	662	8	in	in	ADP
dti-1318	662	9	morphogenesis	morphogenesis	NOUN
dti-1318	662	10	and	and	CCONJ
dti-1318	662	11	infectivity	infectivity	NOUN
dti-1318	662	12	of	of	ADP
dti-1318	662	13	human	human	ADJ
dti-1318	662	14	immunodefi	immunodefi	PROPN
dti-1318	662	15	ciency	ciency	NOUN
dti-1318	662	16	virus	virus	NOUN
dti-1318	662	17	type	type	NOUN
dti-1318	662	18	1	1	NUM
dti-1318	662	19	.	.	PUNCT
dti-1318	662	20	proc	proc	PROPN
dti-1318	662	21	.	.	PUNCT
dti-1318	663	1	natl	natl	PROPN
dti-1318	663	2	.	.	PUNCT
dti-1318	664	1	acad	acad	PROPN
dti-1318	664	2	.	.	PUNCT
dti-1318	665	1	sci	sci	PROPN
dti-1318	665	2	.	.	PUNCT
dti-1318	665	3	u.s.a	u.s.a	PROPN
dti-1318	665	4	.	.	PROPN
dti-1318	665	5	,	,	PUNCT
dti-1318	665	6	86:5781–5785	86:5781–5785	NUM
dti-1318	665	7	.	.	PUNCT
dti-1318	666	1	grice	grice	PROPN
dti-1318	666	2	,	,	PUNCT
dti-1318	666	3	a.l	a.l	PROPN
dti-1318	666	4	.	.	PROPN
dti-1318	666	5	,	,	PUNCT
dti-1318	666	6	kerr	kerr	PROPN
dti-1318	666	7	,	,	PUNCT
dti-1318	666	8	i.d	i.d	PROPN
dti-1318	666	9	.	.	PROPN
dti-1318	666	10	and	and	CCONJ
dti-1318	666	11	sansom	sansom	PROPN
dti-1318	666	12	,	,	PUNCT
dti-1318	666	13	m.s	m.s	PROPN
dti-1318	666	14	.	.	PROPN
dti-1318	666	15	1997	1997	NUM
dti-1318	666	16	.	.	PUNCT
dti-1318	667	1	ion	ion	NOUN
dti-1318	667	2	channels	channel	NOUN
dti-1318	667	3	formed	form	VERB
dti-1318	667	4	by	by	ADP
dti-1318	667	5	hiv-1	hiv-1	PUNCT
dti-1318	667	6	vpu	vpu	NOUN
dti-1318	667	7	:	:	PUNCT
dti-1318	667	8	a	a	DET
dti-1318	667	9	modelling	modelling	NOUN
dti-1318	667	10	and	and	CCONJ
dti-1318	667	11	simulation	simulation	NOUN
dti-1318	667	12	study	study	PROPN
dti-1318	667	13	.	.	PUNCT
dti-1318	668	1	febs	febs	PROPN
dti-1318	668	2	lett	lett	PROPN
dti-1318	668	3	.	.	PUNCT
dti-1318	668	4	,	,	PUNCT
dti-1318	668	5	405	405	NUM
dti-1318	668	6	:	:	PUNCT
dti-1318	668	7	299–304	299–304	NUM
dti-1318	668	8	.	.	PUNCT
dti-1318	669	1	grinsztejn	grinsztejn	PROPN
dti-1318	669	2	,	,	PUNCT
dti-1318	669	3	b.	b.	PROPN
dti-1318	669	4	,	,	PUNCT
dti-1318	669	5	nguyen	nguyen	PROPN
dti-1318	669	6	,	,	PUNCT
dti-1318	669	7	b.y	b.y	PROPN
dti-1318	669	8	.	.	PROPN
dti-1318	669	9	,	,	PUNCT
dti-1318	669	10	katlama	katlama	PROPN
dti-1318	669	11	,	,	PUNCT
dti-1318	669	12	c.	c.	PROPN
dti-1318	669	13	,	,	PUNCT
dti-1318	669	14	gatell	gatell	PROPN
dti-1318	669	15	,	,	PUNCT
dti-1318	669	16	j.m	j.m	PROPN
dti-1318	669	17	.	.	PROPN
dti-1318	669	18	,	,	PUNCT
dti-1318	669	19	lazzarin	lazzarin	PROPN
dti-1318	669	20	,	,	PUNCT
dti-1318	669	21	a.	a.	NOUN
dti-1318	669	22	,	,	PUNCT
dti-1318	669	23	vittecoq	vittecoq	NOUN
dti-1318	669	24	,	,	PUNCT
dti-1318	669	25	d.	d.	PROPN
dti-1318	669	26	,	,	PUNCT
dti-1318	669	27	gonzalez	gonzalez	PROPN
dti-1318	669	28	,	,	PUNCT
dti-1318	669	29	c.j	c.j	PROPN
dti-1318	669	30	.	.	PROPN
dti-1318	669	31	,	,	PUNCT
dti-1318	669	32	chen	chen	PROPN
dti-1318	669	33	,	,	PUNCT
dti-1318	669	34	j.	j.	PROPN
dti-1318	669	35	,	,	PUNCT
dti-1318	669	36	harvey	harvey	PROPN
dti-1318	669	37	,	,	PUNCT
dti-1318	669	38	c.m	c.m	PROPN
dti-1318	669	39	.	.	PROPN
dti-1318	669	40	and	and	CCONJ
dti-1318	669	41	isaacs	isaacs	PROPN
dti-1318	669	42	,	,	PUNCT
dti-1318	669	43	r.d	r.d	PROPN
dti-1318	669	44	.	.	PROPN
dti-1318	669	45	2007	2007	NUM
dti-1318	669	46	.	.	PUNCT
dti-1318	670	1	safety	safety	NOUN
dti-1318	670	2	and	and	CCONJ
dti-1318	670	3	effi	effi	PROPN
dti-1318	670	4	cacy	cacy	NOUN
dti-1318	670	5	of	of	ADP
dti-1318	670	6	the	the	DET
dti-1318	670	7	hiv-1	hiv-1	X
dti-1318	670	8	integrase	integrase	NOUN
dti-1318	670	9	inhibitor	inhibitor	NOUN
dti-1318	670	10	raltegravir	raltegravir	PROPN
dti-1318	670	11	(	(	PUNCT
dti-1318	670	12	mk-0518	mk-0518	NOUN
dti-1318	670	13	)	)	PUNCT
dti-1318	670	14	in	in	ADP
dti-1318	670	15	treatment	treatment	NOUN
dti-1318	670	16	-	-	PUNCT
dti-1318	670	17	experienced	experience	VERB
dti-1318	670	18	patients	patient	NOUN
dti-1318	670	19	with	with	ADP
dti-1318	670	20	multidrug	multidrug	NOUN
dti-1318	670	21	-	-	PUNCT
dti-1318	670	22	resistant	resistant	ADJ
dti-1318	670	23	virus	virus	NOUN
dti-1318	670	24	:	:	PUNCT
dti-1318	670	25	a	a	DET
dti-1318	670	26	phase	phase	NOUN
dti-1318	670	27	ii	ii	NOUN
dti-1318	670	28	randomised	randomise	VERB
dti-1318	670	29	controlled	control	VERB
dti-1318	670	30	trial	trial	NOUN
dti-1318	670	31	.	.	PUNCT
dti-1318	671	1	lancet	lancet	PROPN
dti-1318	671	2	,	,	PUNCT
dti-1318	671	3	369:1261–1269	369:1261–1269	NUM
dti-1318	671	4	.	.	PUNCT
dti-1318	671	5	gustchina	gustchina	PROPN
dti-1318	671	6	,	,	PUNCT
dti-1318	671	7	a.	a.	NOUN
dti-1318	671	8	and	and	CCONJ
dti-1318	671	9	weber	weber	PROPN
dti-1318	671	10	,	,	PUNCT
dti-1318	671	11	i.t	i.t	PROPN
dti-1318	671	12	.	.	PROPN
dti-1318	671	13	1991	1991	NUM
dti-1318	671	14	.	.	PUNCT
dti-1318	672	1	comparative	comparative	ADJ
dti-1318	672	2	analysis	analysis	NOUN
dti-1318	672	3	of	of	ADP
dti-1318	672	4	the	the	DET
dti-1318	672	5	sequences	sequence	NOUN
dti-1318	672	6	and	and	CCONJ
dti-1318	672	7	structures	structure	NOUN
dti-1318	672	8	of	of	ADP
dti-1318	672	9	hiv-1	hiv-1	X
dti-1318	672	10	and	and	CCONJ
dti-1318	672	11	hiv-2	hiv-2	PUNCT
dti-1318	672	12	proteases	protease	NOUN
dti-1318	672	13	.	.	PUNCT
dti-1318	673	1	proteins	protein	NOUN
dti-1318	673	2	,	,	PUNCT
dti-1318	673	3	10:325	10:325	NUM
dti-1318	673	4	–	–	PUNCT
dti-1318	673	5	339	339	NUM
dti-1318	673	6	.	.	PUNCT
dti-1318	674	1	handley	handley	PROPN
dti-1318	674	2	,	,	PUNCT
dti-1318	674	3	m.a	m.a	PROPN
dti-1318	674	4	.	.	PROPN
dti-1318	674	5	,	,	PUNCT
dti-1318	674	6	paddock	paddock	NOUN
dti-1318	674	7	,	,	PUNCT
dti-1318	674	8	s.	s.	PROPN
dti-1318	674	9	,	,	PUNCT
dti-1318	674	10	dall	dall	PROPN
dti-1318	674	11	,	,	PUNCT
dti-1318	674	12	a.	a.	NOUN
dti-1318	674	13	and	and	CCONJ
dti-1318	674	14	panganiban	panganiban	PROPN
dti-1318	674	15	,	,	PUNCT
dti-1318	674	16	a.t	a.t	PROPN
dti-1318	674	17	.	.	PROPN
dti-1318	674	18	2001	2001	NUM
dti-1318	674	19	.	.	PUNCT
dti-1318	675	1	association	association	NOUN
dti-1318	675	2	of	of	ADP
dti-1318	675	3	vpu	vpu	NOUN
dti-1318	675	4	-	-	PUNCT
dti-1318	675	5	binding	bind	VERB
dti-1318	675	6	protein	protein	NOUN
dti-1318	675	7	with	with	ADP
dti-1318	675	8	microtubules	microtubule	NOUN
dti-1318	675	9	and	and	CCONJ
dti-1318	675	10	vpu	vpu	NOUN
dti-1318	675	11	-	-	PUNCT
dti-1318	675	12	dependent	dependent	ADJ
dti-1318	675	13	redistribution	redistribution	NOUN
dti-1318	675	14	of	of	ADP
dti-1318	675	15	hiv-1	hiv-1	X
dti-1318	675	16	gag	gag	NOUN
dti-1318	675	17	protein	protein	NOUN
dti-1318	675	18	.	.	PUNCT
dti-1318	676	1	virology	virology	NOUN
dti-1318	676	2	,	,	PUNCT
dti-1318	676	3	291:198–207	291:198–207	NUM
dti-1318	676	4	.	.	PUNCT
dti-1318	677	1	harila	harila	PROPN
dti-1318	677	2	,	,	PUNCT
dti-1318	677	3	k.	k.	PROPN
dti-1318	677	4	,	,	PUNCT
dti-1318	677	5	prior	prior	ADV
dti-1318	677	6	,	,	PUNCT
dti-1318	677	7	i.	i.	NOUN
dti-1318	677	8	,	,	PUNCT
dti-1318	677	9	sjoberg	sjoberg	PROPN
dti-1318	677	10	,	,	PUNCT
dti-1318	677	11	m.	m.	NOUN
dti-1318	677	12	,	,	PUNCT
dti-1318	677	13	salminen	salminen	NOUN
dti-1318	677	14	,	,	PUNCT
dti-1318	677	15	a.	a.	NOUN
dti-1318	677	16	,	,	PUNCT
dti-1318	677	17	hinkula	hinkula	PROPN
dti-1318	677	18	,	,	PUNCT
dti-1318	677	19	j.	j.	PROPN
dti-1318	677	20	and	and	CCONJ
dti-1318	677	21	suomalainen	suomalainen	PROPN
dti-1318	677	22	,	,	PUNCT
dti-1318	677	23	m.	m.	NOUN
dti-1318	677	24	2006	2006	NUM
dti-1318	677	25	.	.	PUNCT
dti-1318	678	1	vpu	vpu	NOUN
dti-1318	678	2	and	and	CCONJ
dti-1318	678	3	tsg101	tsg101	PROPN
dti-1318	678	4	regulate	regulate	VERB
dti-1318	678	5	intracellular	intracellular	ADJ
dti-1318	678	6	targeting	targeting	NOUN
dti-1318	678	7	of	of	ADP
dti-1318	678	8	the	the	DET
dti-1318	678	9	human	human	ADJ
dti-1318	678	10	immunodefi	immunodefi	PROPN
dti-1318	678	11	ciency	ciency	NOUN
dti-1318	678	12	virus	virus	NOUN
dti-1318	678	13	type	type	NOUN
dti-1318	678	14	1	1	NUM
dti-1318	678	15	core	core	NOUN
dti-1318	678	16	protein	protein	NOUN
dti-1318	678	17	precursor	precursor	NOUN
dti-1318	678	18	pr55gag	pr55gag	NOUN
dti-1318	678	19	.	.	PUNCT
dti-1318	679	1	j.	j.	PROPN
dti-1318	679	2	virol	virol	PROPN
dti-1318	679	3	.	.	PUNCT
dti-1318	679	4	,	,	PUNCT
dti-1318	679	5	80:3765–3772	80:3765–3772	PROPN
dti-1318	679	6	.	.	PUNCT
dti-1318	679	7	hehl	hehl	NOUN
dti-1318	679	8	,	,	PUNCT
dti-1318	679	9	e.a	e.a	PROPN
dti-1318	679	10	.	.	PROPN
dti-1318	679	11	,	,	PUNCT
dti-1318	679	12	joshi	joshi	PROPN
dti-1318	679	13	,	,	PUNCT
dti-1318	679	14	p.	p.	PROPN
dti-1318	679	15	,	,	PUNCT
dti-1318	679	16	kalpana	kalpana	PROPN
dti-1318	679	17	,	,	PUNCT
dti-1318	679	18	g.v	g.v	PROPN
dti-1318	679	19	.	.	PROPN
dti-1318	679	20	and	and	CCONJ
dti-1318	679	21	prasad	prasad	PROPN
dti-1318	679	22	,	,	PUNCT
dti-1318	679	23	v.r	v.r	PROPN
dti-1318	679	24	.	.	NOUN
dti-1318	679	25	2004	2004	NUM
dti-1318	679	26	.	.	PUNCT
dti-1318	680	1	interaction	interaction	NOUN
dti-1318	680	2	between	between	ADP
dti-1318	680	3	human	human	ADJ
dti-1318	680	4	immunodefi	immunodefi	PROPN
dti-1318	680	5	ciency	ciency	NOUN
dti-1318	680	6	virus	virus	NOUN
dti-1318	680	7	type	type	NOUN
dti-1318	680	8	1	1	NUM
dti-1318	680	9	reverse	reverse	NOUN
dti-1318	680	10	transcriptase	transcriptase	NOUN
dti-1318	680	11	and	and	CCONJ
dti-1318	680	12	integrase	integrase	VERB
dti-1318	680	13	proteins	protein	NOUN
dti-1318	680	14	.	.	PUNCT
dti-1318	681	1	j.	j.	PROPN
dti-1318	681	2	virol	virol	PROPN
dti-1318	681	3	.	.	PUNCT
dti-1318	681	4	,	,	PUNCT
dti-1318	681	5	78:5056–5067	78:5056–5067	X
dti-1318	681	6	.	.	PUNCT
dti-1318	681	7	hill	hill	PROPN
dti-1318	681	8	,	,	PUNCT
dti-1318	681	9	m.	m.	NOUN
dti-1318	681	10	,	,	PUNCT
dti-1318	681	11	tachedjian	tachedjian	NOUN
dti-1318	681	12	,	,	PUNCT
dti-1318	681	13	g.	g.	PROPN
dti-1318	681	14	and	and	CCONJ
dti-1318	681	15	mak	mak	PROPN
dti-1318	681	16	,	,	PUNCT
dti-1318	681	17	j.	j.	PROPN
dti-1318	681	18	2005	2005	NUM
dti-1318	681	19	.	.	PUNCT
dti-1318	682	1	the	the	DET
dti-1318	682	2	packaging	packaging	NOUN
dti-1318	682	3	and	and	CCONJ
dti-1318	682	4	maturation	maturation	NOUN
dti-1318	682	5	of	of	ADP
dti-1318	682	6	the	the	DET
dti-1318	682	7	hiv-1	hiv-1	X
dti-1318	682	8	pol	pol	NOUN
dti-1318	682	9	proteins	protein	NOUN
dti-1318	682	10	.	.	PUNCT
dti-1318	683	1	curr	curr	PROPN
dti-1318	683	2	.	.	PUNCT
dti-1318	684	1	hiv	hiv	PROPN
dti-1318	684	2	.	.	PUNCT
dti-1318	685	1	res	re	NOUN
dti-1318	685	2	.	.	PROPN
dti-1318	685	3	,	,	PUNCT
dti-1318	685	4	3:73–85	3:73–85	NUM
dti-1318	685	5	.	.	PUNCT
dti-1318	686	1	178	178	NUM
dti-1318	686	2	wapling	waple	VERB
dti-1318	686	3	et	et	PROPN
dti-1318	686	4	al	al	PROPN
dti-1318	686	5	drug	drug	PROPN
dti-1318	686	6	target	target	NOUN
dti-1318	686	7	insights	insight	NOUN
dti-1318	686	8	2007	2007	NUM
dti-1318	686	9	:	:	PUNCT
dti-1318	686	10	2	2	NUM
dti-1318	686	11	himmel	himmel	X
dti-1318	686	12	,	,	PUNCT
dti-1318	686	13	d.m	d.m	PROPN
dti-1318	686	14	.	.	PROPN
dti-1318	686	15	,	,	PUNCT
dti-1318	686	16	sarafi	sarafi	PROPN
dti-1318	686	17	anos	anos	PROPN
dti-1318	686	18	,	,	PUNCT
dti-1318	686	19	s.g	s.g	PROPN
dti-1318	686	20	.	.	PROPN
dti-1318	686	21	,	,	PUNCT
dti-1318	686	22	dharmasena	dharmasena	PROPN
dti-1318	686	23	,	,	PUNCT
dti-1318	686	24	s.	s.	PROPN
dti-1318	686	25	,	,	PUNCT
dti-1318	686	26	hossain	hossain	PROPN
dti-1318	686	27	,	,	PUNCT
dti-1318	686	28	m.m	m.m	PROPN
dti-1318	686	29	.	.	PROPN
dti-1318	686	30	,	,	PUNCT
dti-1318	686	31	mccoysimandle	mccoysimandle	PROPN
dti-1318	686	32	,	,	PUNCT
dti-1318	686	33	k.	k.	PROPN
dti-1318	686	34	,	,	PUNCT
dti-1318	686	35	ilina	ilina	PROPN
dti-1318	686	36	,	,	PUNCT
dti-1318	686	37	t.	t.	PROPN
dti-1318	686	38	,	,	PUNCT
dti-1318	686	39	clark	clark	PROPN
dti-1318	686	40	,	,	PUNCT
dti-1318	686	41	a.d	a.d	PROPN
dti-1318	686	42	.	.	PROPN
dti-1318	686	43	,	,	PUNCT
dti-1318	686	44	jr	jr	PROPN
dti-1318	686	45	.	.	PROPN
dti-1318	686	46	,	,	PUNCT
dti-1318	686	47	knight	knight	PROPN
dti-1318	686	48	,	,	PUNCT
dti-1318	686	49	j.l	j.l	PROPN
dti-1318	686	50	.	.	PROPN
dti-1318	686	51	,	,	PUNCT
dti-1318	686	52	julias	julias	PROPN
dti-1318	686	53	,	,	PUNCT
dti-1318	686	54	j.g	j.g	PROPN
dti-1318	686	55	.	.	PROPN
dti-1318	686	56	,	,	PUNCT
dti-1318	686	57	clark	clark	PROPN
dti-1318	686	58	,	,	PUNCT
dti-1318	686	59	p.k	p.k	PROPN
dti-1318	686	60	.	.	PROPN
dti-1318	686	61	et	et	PROPN
dti-1318	686	62	al	al	PROPN
dti-1318	686	63	.	.	PROPN
dti-1318	686	64	2006	2006	NUM
dti-1318	686	65	.	.	PUNCT
dti-1318	687	1	hiv-1	hiv-1	X
dti-1318	687	2	reverse	reverse	ADJ
dti-1318	687	3	transcriptase	transcriptase	NOUN
dti-1318	687	4	structure	structure	NOUN
dti-1318	687	5	with	with	ADP
dti-1318	687	6	rnase	rnase	PROPN
dti-1318	687	7	h	h	PROPN
dti-1318	687	8	inhibitor	inhibitor	PROPN
dti-1318	687	9	dihydroxy	dihydroxy	PROPN
dti-1318	687	10	benzoyl	benzoyl	PROPN
dti-1318	687	11	naphthyl	naphthyl	PROPN
dti-1318	687	12	hydrazone	hydrazone	NOUN
dti-1318	687	13	bound	bind	VERB
dti-1318	687	14	at	at	ADP
dti-1318	687	15	a	a	DET
dti-1318	687	16	novel	novel	ADJ
dti-1318	687	17	site	site	NOUN
dti-1318	687	18	.	.	PUNCT
dti-1318	688	1	acs	acs	PROPN
dti-1318	688	2	chem	chem	PROPN
dti-1318	688	3	.	.	PUNCT
dti-1318	689	1	biol	biol	PROPN
dti-1318	689	2	.	.	PUNCT
dti-1318	689	3	,	,	PUNCT
dti-1318	689	4	1:702–712	1:702–712	NOUN
dti-1318	689	5	.	.	PUNCT
dti-1318	690	1	hoglund	hoglund	PROPN
dti-1318	690	2	,	,	PUNCT
dti-1318	690	3	s.	s.	PROPN
dti-1318	690	4	,	,	PUNCT
dti-1318	690	5	su	su	PROPN
dti-1318	690	6	,	,	PUNCT
dti-1318	690	7	j.	j.	PROPN
dti-1318	690	8	,	,	PUNCT
dti-1318	690	9	reneby	reneby	PROPN
dti-1318	690	10	,	,	PUNCT
dti-1318	690	11	s.s	s.s	PROPN
dti-1318	690	12	.	.	PROPN
dti-1318	690	13	,	,	PUNCT
dti-1318	690	14	vegvari	vegvari	PROPN
dti-1318	690	15	,	,	PUNCT
dti-1318	690	16	a.	a.	NOUN
dti-1318	690	17	,	,	PUNCT
dti-1318	690	18	hjerten	hjerten	PROPN
dti-1318	690	19	,	,	PUNCT
dti-1318	690	20	s.	s.	PROPN
dti-1318	690	21	,	,	PUNCT
dti-1318	690	22	sintorn	sintorn	VERB
dti-1318	690	23	,	,	PUNCT
dti-1318	690	24	i.m	i.m	PROPN
dti-1318	690	25	.	.	PROPN
dti-1318	690	26	,	,	PUNCT
dti-1318	690	27	foster	foster	PROPN
dti-1318	690	28	,	,	PUNCT
dti-1318	690	29	h.	h.	PROPN
dti-1318	690	30	,	,	PUNCT
dti-1318	690	31	wu	wu	PROPN
dti-1318	690	32	,	,	PUNCT
dti-1318	690	33	y.p	y.p	PROPN
dti-1318	690	34	.	.	PROPN
dti-1318	690	35	,	,	PUNCT
dti-1318	690	36	nystrom	nystrom	PROPN
dti-1318	690	37	,	,	PUNCT
dti-1318	690	38	i.	i.	PROPN
dti-1318	690	39	and	and	CCONJ
dti-1318	690	40	vahlne	vahlne	PROPN
dti-1318	690	41	,	,	PUNCT
dti-1318	690	42	a.	a.	NOUN
dti-1318	690	43	2002	2002	NUM
dti-1318	690	44	.	.	PUNCT
dti-1318	691	1	tripeptide	tripeptide	ADP
dti-1318	691	2	interference	interference	NOUN
dti-1318	691	3	with	with	ADP
dti-1318	691	4	human	human	ADJ
dti-1318	691	5	immunodefi	immunodefi	PROPN
dti-1318	691	6	ciency	ciency	NOUN
dti-1318	691	7	virus	virus	NOUN
dti-1318	691	8	type	type	NOUN
dti-1318	691	9	1	1	NUM
dti-1318	691	10	morphogenesis	morphogenesis	NOUN
dti-1318	691	11	.	.	PUNCT
dti-1318	692	1	antimicrob	antimicrob	PROPN
dti-1318	692	2	agents	agents	PROPN
dti-1318	692	3	chemother	chemother	PROPN
dti-1318	692	4	.	.	PUNCT
dti-1318	692	5	,	,	PUNCT
dti-1318	692	6	46:3597–3605	46:3597–3605	PROPN
dti-1318	692	7	.	.	PUNCT
dti-1318	693	1	holm	holm	PROPN
dti-1318	693	2	,	,	PUNCT
dti-1318	693	3	k.	k.	PROPN
dti-1318	693	4	,	,	PUNCT
dti-1318	693	5	weclewicz	weclewicz	NOUN
dti-1318	693	6	,	,	PUNCT
dti-1318	693	7	k.	k.	PROPN
dti-1318	693	8	,	,	PUNCT
dti-1318	693	9	hewson	hewson	PROPN
dti-1318	693	10	,	,	PUNCT
dti-1318	693	11	r.	r.	PROPN
dti-1318	693	12	and	and	CCONJ
dti-1318	693	13	suomalainen	suomalainen	PROPN
dti-1318	693	14	,	,	PUNCT
dti-1318	693	15	m.	m.	NOUN
dti-1318	693	16	2003	2003	NUM
dti-1318	693	17	.	.	PUNCT
dti-1318	694	1	human	human	ADJ
dti-1318	694	2	immunodefi	immunodefi	PROPN
dti-1318	694	3	ciency	ciency	NOUN
dti-1318	694	4	virus	virus	NOUN
dti-1318	694	5	type	type	NOUN
dti-1318	694	6	1	1	NUM
dti-1318	694	7	assembly	assembly	NOUN
dti-1318	694	8	and	and	CCONJ
dti-1318	694	9	lipid	lipid	NOUN
dti-1318	694	10	rafts	raft	NOUN
dti-1318	694	11	:	:	PUNCT
dti-1318	694	12	pr55(gag	pr55(gag	X
dti-1318	694	13	)	)	PUNCT
dti-1318	694	14	associates	associate	NOUN
dti-1318	694	15	with	with	ADP
dti-1318	694	16	membrane	membrane	NOUN
dti-1318	694	17	domains	domain	NOUN
dti-1318	694	18	that	that	PRON
dti-1318	694	19	are	be	AUX
dti-1318	694	20	largely	largely	ADV
dti-1318	694	21	resistant	resistant	ADJ
dti-1318	694	22	to	to	ADP
dti-1318	694	23	brij98	brij98	NOUN
dti-1318	694	24	but	but	CCONJ
dti-1318	694	25	sensitive	sensitive	ADJ
dti-1318	694	26	to	to	ADP
dti-1318	694	27	triton	triton	PROPN
dti-1318	694	28	x-100	x-100	PROPN
dti-1318	694	29	.	.	PUNCT
dti-1318	695	1	j.	j.	PROPN
dti-1318	695	2	virol	virol	PROPN
dti-1318	695	3	.	.	PUNCT
dti-1318	695	4	,	,	PUNCT
dti-1318	695	5	77:4805–4817	77:4805–4817	PROPN
dti-1318	695	6	.	.	PUNCT
dti-1318	695	7	hosokawa	hosokawa	PROPN
dti-1318	695	8	,	,	PUNCT
dti-1318	695	9	m.	m.	NOUN
dti-1318	695	10	,	,	PUNCT
dti-1318	695	11	imai	imai	PROPN
dti-1318	695	12	,	,	PUNCT
dti-1318	695	13	m.	m.	NOUN
dti-1318	695	14	,	,	PUNCT
dti-1318	695	15	okada	okada	PROPN
dti-1318	695	16	,	,	PUNCT
dti-1318	695	17	h.	h.	PROPN
dti-1318	695	18	and	and	CCONJ
dti-1318	695	19	okada	okada	PROPN
dti-1318	695	20	,	,	PUNCT
dti-1318	695	21	n.	n.	PROPN
dti-1318	695	22	2004	2004	NUM
dti-1318	695	23	.	.	PUNCT
dti-1318	696	1	inhibition	inhibition	NOUN
dti-1318	696	2	of	of	ADP
dti-1318	696	3	hiv-1	hiv-1	ADJ
dti-1318	696	4	infection	infection	NOUN
dti-1318	696	5	in	in	ADP
dti-1318	696	6	cells	cell	NOUN
dti-1318	696	7	expressing	express	VERB
dti-1318	696	8	an	an	DET
dti-1318	696	9	artifi	artifi	ADJ
dti-1318	696	10	cial	cial	ADJ
dti-1318	696	11	complementary	complementary	ADJ
dti-1318	696	12	peptide	peptide	NOUN
dti-1318	696	13	.	.	PUNCT
dti-1318	697	1	biochem	biochem	PROPN
dti-1318	697	2	.	.	PUNCT
dti-1318	698	1	biophys	biophy	NOUN
dti-1318	698	2	.	.	PUNCT
dti-1318	699	1	res	re	NOUN
dti-1318	699	2	.	.	PUNCT
dti-1318	700	1	commun	commun	PROPN
dti-1318	700	2	.	.	PROPN
dti-1318	700	3	,	,	PUNCT
dti-1318	700	4	324:236–240	324:236–240	NUM
dti-1318	700	5	.	.	PUNCT
dti-1318	701	1	hout	hout	PROPN
dti-1318	701	2	,	,	PUNCT
dti-1318	701	3	d.r	d.r	PROPN
dti-1318	701	4	.	.	PROPN
dti-1318	701	5	,	,	PUNCT
dti-1318	701	6	gomez	gomez	PROPN
dti-1318	701	7	,	,	PUNCT
dti-1318	701	8	l.m	l.m	PROPN
dti-1318	701	9	.	.	PROPN
dti-1318	701	10	,	,	PUNCT
dti-1318	701	11	pacyniak	pacyniak	PROPN
dti-1318	701	12	,	,	PUNCT
dti-1318	701	13	e.	e.	PROPN
dti-1318	701	14	,	,	PUNCT
dti-1318	701	15	miller	miller	PROPN
dti-1318	701	16	,	,	PUNCT
dti-1318	701	17	j.m	j.m	PROPN
dti-1318	701	18	.	.	PROPN
dti-1318	701	19	,	,	PUNCT
dti-1318	701	20	hill	hill	PROPN
dti-1318	701	21	,	,	PUNCT
dti-1318	701	22	m.s	m.s	PROPN
dti-1318	701	23	.	.	PROPN
dti-1318	701	24	and	and	CCONJ
dti-1318	701	25	stephens	stephens	PROPN
dti-1318	701	26	,	,	PUNCT
dti-1318	701	27	e.b	e.b	PROPN
dti-1318	701	28	.	.	PROPN
dti-1318	701	29	2006	2006	NUM
dti-1318	701	30	.	.	PUNCT
dti-1318	702	1	a	a	DET
dti-1318	702	2	single	single	ADJ
dti-1318	702	3	amino	amino	NOUN
dti-1318	702	4	acid	acid	NOUN
dti-1318	702	5	substitution	substitution	NOUN
dti-1318	702	6	within	within	ADP
dti-1318	702	7	the	the	DET
dti-1318	702	8	transmembrane	transmembrane	ADJ
dti-1318	702	9	domain	domain	NOUN
dti-1318	702	10	of	of	ADP
dti-1318	702	11	the	the	DET
dti-1318	702	12	human	human	ADJ
dti-1318	702	13	immunodefi	immunodefi	PROPN
dti-1318	702	14	ciency	ciency	NOUN
dti-1318	702	15	virus	virus	NOUN
dti-1318	702	16	type	type	NOUN
dti-1318	702	17	1	1	NUM
dti-1318	702	18	vpu	vpu	NOUN
dti-1318	702	19	protein	protein	NOUN
dti-1318	702	20	renders	render	VERB
dti-1318	702	21	simian	simian	ADJ
dti-1318	702	22	-	-	PUNCT
dti-1318	702	23	human	human	ADJ
dti-1318	702	24	immunodefi	immunodefi	PROPN
dti-1318	702	25	ciency	ciency	NOUN
dti-1318	702	26	virus	virus	NOUN
dti-1318	702	27	(	(	PUNCT
dti-1318	702	28	shiv(ku-1bmc33	shiv(ku-1bmc33	NOUN
dti-1318	702	29	)	)	PUNCT
dti-1318	702	30	)	)	PUNCT
dti-1318	702	31	susceptible	susceptible	ADJ
dti-1318	702	32	to	to	ADP
dti-1318	702	33	rimantadine	rimantadine	NOUN
dti-1318	702	34	.	.	PUNCT
dti-1318	703	1	virology	virology	NOUN
dti-1318	703	2	,	,	PUNCT
dti-1318	703	3	348:449–461	348:449–461	NUM
dti-1318	703	4	.	.	PUNCT
dti-1318	704	1	hsu	hsu	PROPN
dti-1318	704	2	,	,	PUNCT
dti-1318	704	3	k.	k.	PROPN
dti-1318	704	4	,	,	PUNCT
dti-1318	704	5	seharaseyon	seharaseyon	PROPN
dti-1318	704	6	,	,	PUNCT
dti-1318	704	7	j.	j.	PROPN
dti-1318	704	8	,	,	PUNCT
dti-1318	704	9	dong	dong	PROPN
dti-1318	704	10	,	,	PUNCT
dti-1318	704	11	p.	p.	PROPN
dti-1318	704	12	,	,	PUNCT
dti-1318	704	13	bour	bour	PROPN
dti-1318	704	14	,	,	PUNCT
dti-1318	704	15	s.	s.	PROPN
dti-1318	704	16	and	and	CCONJ
dti-1318	704	17	marban	marban	PROPN
dti-1318	704	18	,	,	PUNCT
dti-1318	704	19	e.	e.	PROPN
dti-1318	704	20	2004	2004	PROPN
dti-1318	704	21	.	.	PUNCT
dti-1318	705	1	mutual	mutual	ADJ
dti-1318	705	2	functional	functional	ADJ
dti-1318	705	3	destruction	destruction	NOUN
dti-1318	705	4	of	of	ADP
dti-1318	705	5	hiv-1	hiv-1	X
dti-1318	705	6	vpu	vpu	NOUN
dti-1318	705	7	and	and	CCONJ
dti-1318	705	8	host	host	NOUN
dti-1318	705	9	task-1	task-1	NUM
dti-1318	705	10	channel	channel	NOUN
dti-1318	705	11	.	.	PUNCT
dti-1318	706	1	mol	mol	PROPN
dti-1318	706	2	.	.	PROPN
dti-1318	706	3	cell	cell	NOUN
dti-1318	706	4	,	,	PUNCT
dti-1318	706	5	14:259–267	14:259–267	NUM
dti-1318	706	6	.	.	PUNCT
dti-1318	707	1	huang	huang	PROPN
dti-1318	707	2	,	,	PUNCT
dti-1318	707	3	m.	m.	NOUN
dti-1318	707	4	,	,	PUNCT
dti-1318	707	5	orenstein	orenstein	ADJ
dti-1318	707	6	,	,	PUNCT
dti-1318	707	7	j.m	j.m	PROPN
dti-1318	707	8	.	.	PROPN
dti-1318	707	9	,	,	PUNCT
dti-1318	707	10	martin	martin	PROPN
dti-1318	707	11	,	,	PUNCT
dti-1318	707	12	m.a	m.a	PROPN
dti-1318	707	13	.	.	PROPN
dti-1318	707	14	and	and	CCONJ
dti-1318	707	15	freed	free	VERB
dti-1318	707	16	,	,	PUNCT
dti-1318	707	17	e.o	e.o	PROPN
dti-1318	707	18	.	.	PROPN
dti-1318	707	19	1995	1995	NUM
dti-1318	707	20	.	.	PUNCT
dti-1318	708	1	p6gag	p6gag	ADV
dti-1318	708	2	is	be	AUX
dti-1318	708	3	required	require	VERB
dti-1318	708	4	for	for	ADP
dti-1318	708	5	particle	particle	NOUN
dti-1318	708	6	production	production	NOUN
dti-1318	708	7	from	from	ADP
dti-1318	708	8	full	full	ADJ
dti-1318	708	9	-	-	PUNCT
dti-1318	708	10	length	length	NOUN
dti-1318	708	11	human	human	ADJ
dti-1318	708	12	immunodefi	immunodefi	PROPN
dti-1318	708	13	ciency	ciency	NOUN
dti-1318	708	14	virus	virus	NOUN
dti-1318	708	15	type	type	NOUN
dti-1318	708	16	1	1	NUM
dti-1318	708	17	molecular	molecular	ADJ
dti-1318	708	18	clones	clone	NOUN
dti-1318	708	19	expressing	express	VERB
dti-1318	708	20	protease	protease	NOUN
dti-1318	708	21	.	.	PUNCT
dti-1318	709	1	j.	j.	PROPN
dti-1318	709	2	virol	virol	PROPN
dti-1318	709	3	.	.	PUNCT
dti-1318	709	4	,	,	PUNCT
dti-1318	710	1	69:6810–6818	69:6810–6818	PROPN
dti-1318	710	2	.	.	PUNCT
dti-1318	711	1	hung	hung	PROPN
dti-1318	711	2	,	,	PUNCT
dti-1318	711	3	m.	m.	NOUN
dti-1318	711	4	,	,	PUNCT
dti-1318	711	5	patel	patel	PROPN
dti-1318	711	6	,	,	PUNCT
dti-1318	711	7	p.	p.	PROPN
dti-1318	711	8	,	,	PUNCT
dti-1318	711	9	davis	davis	PROPN
dti-1318	711	10	,	,	PUNCT
dti-1318	711	11	s.	s.	PROPN
dti-1318	711	12	and	and	CCONJ
dti-1318	711	13	green	green	PROPN
dti-1318	711	14	,	,	PUNCT
dti-1318	711	15	s.r	s.r	PROPN
dti-1318	711	16	.	.	PROPN
dti-1318	711	17	1998	1998	NUM
dti-1318	711	18	.	.	PUNCT
dti-1318	712	1	importance	importance	NOUN
dti-1318	712	2	of	of	ADP
dti-1318	712	3	ribosomal	ribosomal	NOUN
dti-1318	712	4	frameshifting	frameshifting	NOUN
dti-1318	712	5	for	for	ADP
dti-1318	712	6	human	human	ADJ
dti-1318	712	7	immunodefi	immunodefi	PROPN
dti-1318	712	8	ciency	ciency	NOUN
dti-1318	712	9	virus	virus	NOUN
dti-1318	712	10	type	type	NOUN
dti-1318	712	11	1	1	NUM
dti-1318	712	12	particle	particle	NOUN
dti-1318	712	13	assembly	assembly	NOUN
dti-1318	712	14	and	and	CCONJ
dti-1318	712	15	replication	replication	NOUN
dti-1318	712	16	.	.	PUNCT
dti-1318	713	1	j.	j.	PROPN
dti-1318	713	2	virol	virol	PROPN
dti-1318	713	3	.	.	PUNCT
dti-1318	713	4	,	,	PUNCT
dti-1318	714	1	72:4819–4824	72:4819–4824	X
dti-1318	714	2	.	.	PUNCT
dti-1318	715	1	jacks	jack	NOUN
dti-1318	715	2	,	,	PUNCT
dti-1318	715	3	t.	t.	PROPN
dti-1318	715	4	,	,	PUNCT
dti-1318	715	5	madhani	madhani	PROPN
dti-1318	715	6	,	,	PUNCT
dti-1318	715	7	h.d	h.d	PROPN
dti-1318	715	8	.	.	PROPN
dti-1318	715	9	,	,	PUNCT
dti-1318	715	10	masiarz	masiarz	PROPN
dti-1318	715	11	,	,	PUNCT
dti-1318	715	12	f.r	f.r	PROPN
dti-1318	715	13	.	.	PROPN
dti-1318	715	14	and	and	CCONJ
dti-1318	715	15	varmus	varmus	PROPN
dti-1318	715	16	,	,	PUNCT
dti-1318	715	17	h.e	h.e	PROPN
dti-1318	715	18	.	.	PROPN
dti-1318	715	19	1988a	1988a	NUM
dti-1318	715	20	.	.	PUNCT
dti-1318	716	1	signals	signal	NOUN
dti-1318	716	2	for	for	ADP
dti-1318	716	3	ribosomal	ribosomal	NOUN
dti-1318	716	4	frameshifting	frameshifting	NOUN
dti-1318	716	5	in	in	ADP
dti-1318	716	6	the	the	DET
dti-1318	716	7	rous	rous	ADJ
dti-1318	716	8	sarcoma	sarcoma	NOUN
dti-1318	716	9	virus	virus	NOUN
dti-1318	716	10	gag	gag	NOUN
dti-1318	716	11	-	-	PUNCT
dti-1318	716	12	pol	pol	NOUN
dti-1318	716	13	region	region	NOUN
dti-1318	716	14	.	.	PUNCT
dti-1318	717	1	cell	cell	NOUN
dti-1318	717	2	,	,	PUNCT
dti-1318	717	3	55:447–458	55:447–458	PROPN
dti-1318	717	4	.	.	PUNCT
dti-1318	717	5	jacks	jack	NOUN
dti-1318	717	6	,	,	PUNCT
dti-1318	717	7	t.	t.	PROPN
dti-1318	717	8	,	,	PUNCT
dti-1318	717	9	power	power	NOUN
dti-1318	717	10	,	,	PUNCT
dti-1318	717	11	m.d	m.d	PROPN
dti-1318	717	12	.	.	PROPN
dti-1318	717	13	,	,	PUNCT
dti-1318	717	14	masiarz	masiarz	PROPN
dti-1318	717	15	,	,	PUNCT
dti-1318	717	16	f.r	f.r	PROPN
dti-1318	717	17	.	.	PROPN
dti-1318	717	18	,	,	PUNCT
dti-1318	717	19	luciw	luciw	NOUN
dti-1318	717	20	,	,	PUNCT
dti-1318	717	21	p.a	p.a	PROPN
dti-1318	717	22	.	.	PROPN
dti-1318	717	23	,	,	PUNCT
dti-1318	717	24	barr	barr	PROPN
dti-1318	717	25	,	,	PUNCT
dti-1318	717	26	p.j	p.j	PROPN
dti-1318	717	27	.	.	PROPN
dti-1318	717	28	and	and	CCONJ
dti-1318	717	29	varmus	varmus	PROPN
dti-1318	717	30	,	,	PUNCT
dti-1318	717	31	h.e	h.e	PROPN
dti-1318	717	32	.	.	PROPN
dti-1318	717	33	1988b	1988b	NUM
dti-1318	717	34	.	.	PUNCT
dti-1318	718	1	characterization	characterization	NOUN
dti-1318	718	2	of	of	ADP
dti-1318	718	3	ribosomal	ribosomal	NOUN
dti-1318	718	4	frameshifting	frameshifting	NOUN
dti-1318	718	5	in	in	ADP
dti-1318	718	6	hiv-1	hiv-1	PUNCT
dti-1318	718	7	gag	gag	NOUN
dti-1318	718	8	-	-	PUNCT
dti-1318	718	9	pol	pol	NOUN
dti-1318	718	10	expression	expression	NOUN
dti-1318	718	11	.	.	PUNCT
dti-1318	719	1	nature	nature	NOUN
dti-1318	719	2	,	,	PUNCT
dti-1318	719	3	331:280–283	331:280–283	NUM
dti-1318	719	4	.	.	PUNCT
dti-1318	720	1	jacks	jack	NOUN
dti-1318	720	2	,	,	PUNCT
dti-1318	720	3	t.	t.	PROPN
dti-1318	720	4	,	,	PUNCT
dti-1318	720	5	townsley	townsley	PROPN
dti-1318	720	6	,	,	PUNCT
dti-1318	720	7	k.	k.	PROPN
dti-1318	720	8	,	,	PUNCT
dti-1318	720	9	varmus	varmus	NOUN
dti-1318	720	10	,	,	PUNCT
dti-1318	720	11	and	and	CCONJ
dti-1318	720	12	h.e	h.e	PROPN
dti-1318	720	13	.	.	PROPN
dti-1318	720	14	majors	major	NOUN
dti-1318	720	15	,	,	PUNCT
dti-1318	720	16	j.	j.	PROPN
dti-1318	720	17	1987	1987	NUM
dti-1318	720	18	.	.	PUNCT
dti-1318	721	1	two	two	NUM
dti-1318	721	2	effi	effi	PROPN
dti-1318	721	3	cient	cient	PROPN
dti-1318	721	4	ribosomal	ribosomal	NOUN
dti-1318	721	5	frameshifting	frameshifte	VERB
dti-1318	721	6	events	event	NOUN
dti-1318	721	7	are	be	AUX
dti-1318	721	8	required	require	VERB
dti-1318	721	9	for	for	ADP
dti-1318	721	10	synthesis	synthesis	NOUN
dti-1318	721	11	of	of	ADP
dti-1318	721	12	mouse	mouse	NOUN
dti-1318	721	13	mammary	mammary	ADJ
dti-1318	721	14	tumor	tumor	NOUN
dti-1318	721	15	virus	virus	NOUN
dti-1318	721	16	gag	gag	NOUN
dti-1318	721	17	-	-	PUNCT
dti-1318	721	18	related	relate	VERB
dti-1318	721	19	polyproteins	polyprotein	NOUN
dti-1318	721	20	.	.	PUNCT
dti-1318	722	1	proc	proc	PROPN
dti-1318	722	2	.	.	PUNCT
dti-1318	723	1	natl	natl	PROPN
dti-1318	723	2	.	.	PUNCT
dti-1318	724	1	acad	acad	PROPN
dti-1318	724	2	.	.	PUNCT
dti-1318	725	1	sci	sci	PROPN
dti-1318	725	2	.	.	PUNCT
dti-1318	725	3	u.s.a	u.s.a	PROPN
dti-1318	725	4	.	.	PROPN
dti-1318	725	5	,	,	PUNCT
dti-1318	725	6	84:4298–4302	84:4298–4302	PROPN
dti-1318	725	7	.	.	PUNCT
dti-1318	725	8	jacks	jack	NOUN
dti-1318	725	9	,	,	PUNCT
dti-1318	725	10	t.	t.	NOUN
dti-1318	725	11	and	and	CCONJ
dti-1318	725	12	varmus	varmus	PROPN
dti-1318	725	13	,	,	PUNCT
dti-1318	725	14	h.e	h.e	PROPN
dti-1318	725	15	.	.	PROPN
dti-1318	725	16	1985	1985	NUM
dti-1318	725	17	.	.	PUNCT
dti-1318	726	1	expression	expression	NOUN
dti-1318	726	2	of	of	ADP
dti-1318	726	3	the	the	DET
dti-1318	726	4	rous	rous	ADJ
dti-1318	726	5	sarcoma	sarcoma	NOUN
dti-1318	726	6	virus	virus	NOUN
dti-1318	726	7	pol	pol	PROPN
dti-1318	726	8	gene	gene	NOUN
dti-1318	726	9	by	by	ADP
dti-1318	726	10	ribosomal	ribosomal	NOUN
dti-1318	726	11	frameshifting	frameshifting	NOUN
dti-1318	726	12	.	.	PUNCT
dti-1318	727	1	science	science	NOUN
dti-1318	727	2	,	,	PUNCT
dti-1318	727	3	230:1237–1242	230:1237–1242	PROPN
dti-1318	727	4	.	.	PUNCT
dti-1318	728	1	jacobo	jacobo	PROPN
dti-1318	728	2	-	-	PUNCT
dti-1318	728	3	molina	molina	PROPN
dti-1318	728	4	,	,	PUNCT
dti-1318	728	5	a.	a.	NOUN
dti-1318	728	6	,	,	PUNCT
dti-1318	728	7	ding	ding	NOUN
dti-1318	728	8	,	,	PUNCT
dti-1318	728	9	j.	j.	PROPN
dti-1318	728	10	,	,	PUNCT
dti-1318	728	11	nanni	nanni	PROPN
dti-1318	728	12	,	,	PUNCT
dti-1318	728	13	r.g	r.g	PROPN
dti-1318	728	14	.	.	PROPN
dti-1318	728	15	,	,	PUNCT
dti-1318	728	16	clark	clark	PROPN
dti-1318	728	17	,	,	PUNCT
dti-1318	728	18	a.d	a.d	PROPN
dti-1318	728	19	.	.	PROPN
dti-1318	728	20	,	,	PUNCT
dti-1318	728	21	jr	jr	PROPN
dti-1318	728	22	.	.	PROPN
dti-1318	728	23	,	,	PUNCT
dti-1318	728	24	lu	lu	PROPN
dti-1318	728	25	,	,	PUNCT
dti-1318	728	26	x.	x.	NOUN
dti-1318	728	27	,	,	PUNCT
dti-1318	728	28	tantillo	tantillo	PROPN
dti-1318	728	29	,	,	PUNCT
dti-1318	728	30	c.	c.	PROPN
dti-1318	728	31	,	,	PUNCT
dti-1318	728	32	williams	williams	PROPN
dti-1318	728	33	,	,	PUNCT
dti-1318	728	34	r.l	r.l	PROPN
dti-1318	728	35	.	.	PROPN
dti-1318	728	36	,	,	PUNCT
dti-1318	728	37	kamer	kamer	PROPN
dti-1318	728	38	,	,	PUNCT
dti-1318	728	39	g.	g.	PROPN
dti-1318	728	40	,	,	PUNCT
dti-1318	728	41	ferris	ferris	PROPN
dti-1318	728	42	,	,	PUNCT
dti-1318	728	43	a.l	a.l	PROPN
dti-1318	728	44	.	.	PROPN
dti-1318	728	45	,	,	PUNCT
dti-1318	728	46	clark	clark	PROPN
dti-1318	728	47	,	,	PUNCT
dti-1318	728	48	p.	p.	NOUN
dti-1318	728	49	et	et	NOUN
dti-1318	729	1	al	al	PROPN
dti-1318	729	2	.	.	PROPN
dti-1318	729	3	1993	1993	NUM
dti-1318	729	4	.	.	PUNCT
dti-1318	730	1	crystal	crystal	NOUN
dti-1318	730	2	structure	structure	NOUN
dti-1318	730	3	of	of	ADP
dti-1318	730	4	human	human	ADJ
dti-1318	730	5	immunodefi	immunodefi	PROPN
dti-1318	730	6	ciency	ciency	NOUN
dti-1318	730	7	virus	virus	NOUN
dti-1318	730	8	type	type	NOUN
dti-1318	730	9	1	1	NUM
dti-1318	730	10	reverse	reverse	NOUN
dti-1318	730	11	transcriptase	transcriptase	NOUN
dti-1318	730	12	complexed	complexe	VERB
dti-1318	730	13	with	with	ADP
dti-1318	730	14	double	double	ADV
dti-1318	730	15	-	-	PUNCT
dti-1318	730	16	stranded	strand	VERB
dti-1318	730	17	dna	dna	NOUN
dti-1318	730	18	at	at	ADP
dti-1318	730	19	3.0	3.0	NUM
dti-1318	730	20	a	a	DET
dti-1318	730	21	resolution	resolution	NOUN
dti-1318	730	22	shows	show	VERB
dti-1318	730	23	bent	bent	ADJ
dti-1318	730	24	dna	dna	PROPN
dti-1318	730	25	.	.	PUNCT
dti-1318	731	1	proc	proc	PROPN
dti-1318	731	2	.	.	PUNCT
dti-1318	732	1	natl	natl	PROPN
dti-1318	732	2	.	.	PUNCT
dti-1318	733	1	acad	acad	PROPN
dti-1318	733	2	.	.	PUNCT
dti-1318	734	1	sci	sci	PROPN
dti-1318	734	2	.	.	PUNCT
dti-1318	734	3	u.s.a	u.s.a	PROPN
dti-1318	734	4	.	.	PROPN
dti-1318	734	5	,	,	PUNCT
dti-1318	734	6	90:6320–6324	90:6320–6324	NUM
dti-1318	734	7	.	.	PUNCT
dti-1318	735	1	junker	junker	PROPN
dti-1318	735	2	,	,	PUNCT
dti-1318	735	3	u.	u.	PROPN
dti-1318	735	4	,	,	PUNCT
dti-1318	735	5	escaich	escaich	PROPN
dti-1318	735	6	,	,	PUNCT
dti-1318	735	7	s.	s.	PROPN
dti-1318	735	8	,	,	PUNCT
dti-1318	735	9	plavec	plavec	PROPN
dti-1318	735	10	,	,	PUNCT
dti-1318	735	11	i.	i.	PROPN
dti-1318	735	12	,	,	PUNCT
dti-1318	735	13	baker	baker	PROPN
dti-1318	735	14	,	,	PUNCT
dti-1318	735	15	j.	j.	PROPN
dti-1318	735	16	,	,	PUNCT
dti-1318	735	17	mcphee	mcphee	PROPN
dti-1318	735	18	,	,	PUNCT
dti-1318	735	19	f.	f.	PROPN
dti-1318	735	20	,	,	PUNCT
dti-1318	735	21	rose	rise	VERB
dti-1318	735	22	,	,	PUNCT
dti-1318	735	23	j.r	j.r	PROPN
dti-1318	735	24	.	.	PROPN
dti-1318	735	25	,	,	PUNCT
dti-1318	735	26	craik	craik	PROPN
dti-1318	735	27	,	,	PUNCT
dti-1318	735	28	c.s	c.s	PROPN
dti-1318	735	29	.	.	PROPN
dti-1318	735	30	and	and	CCONJ
dti-1318	735	31	bohnlein	bohnlein	PROPN
dti-1318	735	32	,	,	PUNCT
dti-1318	735	33	e.	e.	PROPN
dti-1318	735	34	1996	1996	NUM
dti-1318	735	35	.	.	PUNCT
dti-1318	736	1	intracellular	intracellular	ADJ
dti-1318	736	2	expression	expression	NOUN
dti-1318	736	3	of	of	ADP
dti-1318	736	4	human	human	ADJ
dti-1318	736	5	immunodefi	immunodefi	PROPN
dti-1318	736	6	ciency	ciency	NOUN
dti-1318	736	7	virus	virus	NOUN
dti-1318	736	8	type	type	NOUN
dti-1318	736	9	1	1	NUM
dti-1318	736	10	(	(	PUNCT
dti-1318	736	11	hiv-1	hiv-1	NOUN
dti-1318	736	12	)	)	PUNCT
dti-1318	736	13	protease	protease	NOUN
dti-1318	736	14	variants	variant	NOUN
dti-1318	736	15	inhibits	inhibit	VERB
dti-1318	736	16	replication	replication	NOUN
dti-1318	736	17	of	of	ADP
dti-1318	736	18	wild	wild	ADJ
dti-1318	736	19	-	-	PUNCT
dti-1318	736	20	type	type	NOUN
dti-1318	736	21	and	and	CCONJ
dti-1318	736	22	protease	protease	NOUN
dti-1318	736	23	inhibitor	inhibitor	NOUN
dti-1318	736	24	-	-	PUNCT
dti-1318	736	25	resistant	resistant	ADJ
dti-1318	736	26	hiv-1	hiv-1	X
dti-1318	736	27	strains	strain	NOUN
dti-1318	736	28	in	in	ADP
dti-1318	736	29	human	human	PROPN
dti-1318	736	30	t	t	PROPN
dti-1318	736	31	-	-	PUNCT
dti-1318	736	32	cell	cell	NOUN
dti-1318	736	33	lines	line	NOUN
dti-1318	736	34	.	.	PUNCT
dti-1318	737	1	j.	j.	PROPN
dti-1318	737	2	virol	virol	PROPN
dti-1318	737	3	.	.	PUNCT
dti-1318	737	4	,	,	PUNCT
dti-1318	737	5	70:7765–7772	70:7765–7772	X
dti-1318	737	6	.	.	PUNCT
dti-1318	738	1	kalpana	kalpana	PROPN
dti-1318	738	2	,	,	PUNCT
dti-1318	738	3	g.v	g.v	PROPN
dti-1318	738	4	.	.	PROPN
dti-1318	738	5	,	,	PUNCT
dti-1318	738	6	marmon	marmon	PROPN
dti-1318	738	7	,	,	PUNCT
dti-1318	738	8	s.	s.	PROPN
dti-1318	738	9	,	,	PUNCT
dti-1318	738	10	wang	wang	PROPN
dti-1318	738	11	,	,	PUNCT
dti-1318	738	12	w.	w.	PROPN
dti-1318	738	13	,	,	PUNCT
dti-1318	738	14	crabtree	crabtree	PROPN
dti-1318	738	15	,	,	PUNCT
dti-1318	738	16	g.r	g.r	PROPN
dti-1318	738	17	.	.	PROPN
dti-1318	738	18	and	and	CCONJ
dti-1318	738	19	goff	goff	PROPN
dti-1318	738	20	,	,	PUNCT
dti-1318	738	21	s.p	s.p	PROPN
dti-1318	738	22	.	.	PROPN
dti-1318	738	23	1994	1994	NUM
dti-1318	738	24	.	.	PUNCT
dti-1318	739	1	binding	bind	VERB
dti-1318	739	2	and	and	CCONJ
dti-1318	739	3	stimulation	stimulation	NOUN
dti-1318	739	4	of	of	ADP
dti-1318	739	5	hiv-1	hiv-1	X
dti-1318	739	6	integrase	integrase	NOUN
dti-1318	739	7	by	by	ADP
dti-1318	739	8	a	a	DET
dti-1318	739	9	human	human	ADJ
dti-1318	739	10	homolog	homolog	NOUN
dti-1318	739	11	of	of	ADP
dti-1318	739	12	yeast	yeast	NOUN
dti-1318	739	13	transcription	transcription	NOUN
dti-1318	739	14	factor	factor	NOUN
dti-1318	739	15	snf5	snf5	PROPN
dti-1318	739	16	.	.	PUNCT
dti-1318	740	1	science	science	NOUN
dti-1318	740	2	,	,	PUNCT
dti-1318	740	3	266:2002–2006	266:2002–2006	NUM
dti-1318	740	4	.	.	PUNCT
dti-1318	741	1	kane	kane	PROPN
dti-1318	741	2	,	,	PUNCT
dti-1318	741	3	r.c	r.c	PROPN
dti-1318	741	4	.	.	PROPN
dti-1318	741	5	,	,	PUNCT
dti-1318	741	6	farrell	farrell	PROPN
dti-1318	741	7	,	,	PUNCT
dti-1318	741	8	a.t	a.t	PROPN
dti-1318	741	9	.	.	PROPN
dti-1318	741	10	,	,	PUNCT
dti-1318	741	11	sridhara	sridhara	PROPN
dti-1318	741	12	,	,	PUNCT
dti-1318	741	13	r.	r.	PROPN
dti-1318	741	14	and	and	CCONJ
dti-1318	741	15	pazdur	pazdur	PROPN
dti-1318	741	16	,	,	PUNCT
dti-1318	741	17	r.	r.	PROPN
dti-1318	741	18	2006	2006	NUM
dti-1318	741	19	.	.	PUNCT
dti-1318	742	1	united	united	PROPN
dti-1318	742	2	states	states	PROPN
dti-1318	742	3	food	food	PROPN
dti-1318	742	4	and	and	CCONJ
dti-1318	742	5	drug	drug	PROPN
dti-1318	742	6	administration	administration	PROPN
dti-1318	742	7	approval	approval	NOUN
dti-1318	742	8	summary	summary	NOUN
dti-1318	742	9	:	:	PUNCT
dti-1318	742	10	bortezomib	bortezomib	NOUN
dti-1318	742	11	for	for	ADP
dti-1318	742	12	the	the	DET
dti-1318	742	13	treatment	treatment	NOUN
dti-1318	742	14	of	of	ADP
dti-1318	742	15	progressive	progressive	ADJ
dti-1318	742	16	multiple	multiple	ADJ
dti-1318	742	17	myeloma	myeloma	NOUN
dti-1318	742	18	after	after	ADP
dti-1318	742	19	one	one	NUM
dti-1318	742	20	prior	prior	ADJ
dti-1318	742	21	therapy	therapy	NOUN
dti-1318	742	22	.	.	PUNCT
dti-1318	743	1	clin	clin	PROPN
dti-1318	743	2	.	.	PUNCT
dti-1318	744	1	cancer	cancer	NOUN
dti-1318	744	2	res	re	NOUN
dti-1318	744	3	.	.	PROPN
dti-1318	744	4	,	,	PUNCT
dti-1318	744	5	12:2955–2960	12:2955–2960	NUM
dti-1318	744	6	.	.	PUNCT
dti-1318	745	1	kaplan	kaplan	PROPN
dti-1318	745	2	,	,	PUNCT
dti-1318	745	3	a.h	a.h	PROPN
dti-1318	745	4	.	.	PROPN
dti-1318	745	5	,	,	PUNCT
dti-1318	745	6	manchester	manchester	PROPN
dti-1318	745	7	,	,	PUNCT
dti-1318	745	8	m.	m.	NOUN
dti-1318	745	9	and	and	CCONJ
dti-1318	745	10	swanstrom	swanstrom	NOUN
dti-1318	745	11	,	,	PUNCT
dti-1318	745	12	r.	r.	PROPN
dti-1318	745	13	1994	1994	NUM
dti-1318	745	14	.	.	PUNCT
dti-1318	746	1	the	the	DET
dti-1318	746	2	activity	activity	NOUN
dti-1318	746	3	of	of	ADP
dti-1318	746	4	the	the	DET
dti-1318	746	5	protease	protease	NOUN
dti-1318	746	6	of	of	ADP
dti-1318	746	7	human	human	ADJ
dti-1318	746	8	immunodefi	immunodefi	PROPN
dti-1318	746	9	ciency	ciency	NOUN
dti-1318	746	10	virus	virus	NOUN
dti-1318	746	11	type	type	NOUN
dti-1318	746	12	1	1	NUM
dti-1318	746	13	is	be	AUX
dti-1318	746	14	initiated	initiate	VERB
dti-1318	746	15	at	at	ADP
dti-1318	746	16	the	the	DET
dti-1318	746	17	membrane	membrane	NOUN
dti-1318	746	18	of	of	ADP
dti-1318	746	19	infected	infected	ADJ
dti-1318	746	20	cells	cell	NOUN
dti-1318	746	21	before	before	ADP
dti-1318	746	22	the	the	DET
dti-1318	746	23	release	release	NOUN
dti-1318	746	24	of	of	ADP
dti-1318	746	25	viral	viral	ADJ
dti-1318	746	26	proteins	protein	NOUN
dti-1318	746	27	and	and	CCONJ
dti-1318	746	28	is	be	AUX
dti-1318	746	29	required	require	VERB
dti-1318	746	30	for	for	ADP
dti-1318	746	31	release	release	NOUN
dti-1318	746	32	to	to	PART
dti-1318	746	33	occur	occur	VERB
dti-1318	746	34	with	with	ADP
dti-1318	746	35	maximum	maximum	ADJ
dti-1318	746	36	effi	effi	PROPN
dti-1318	746	37	ciency	ciency	NOUN
dti-1318	746	38	.	.	PUNCT
dti-1318	747	1	j.	j.	PROPN
dti-1318	747	2	virol	virol	PROPN
dti-1318	747	3	.	.	PUNCT
dti-1318	747	4	,	,	PUNCT
dti-1318	747	5	68:6782–6786	68:6782–6786	PROPN
dti-1318	747	6	.	.	PUNCT
dti-1318	748	1	kaplan	kaplan	PROPN
dti-1318	748	2	,	,	PUNCT
dti-1318	748	3	a.h	a.h	PROPN
dti-1318	748	4	.	.	PROPN
dti-1318	748	5	,	,	PUNCT
dti-1318	748	6	zack	zack	PROPN
dti-1318	748	7	,	,	PUNCT
dti-1318	748	8	j.a	j.a	PROPN
dti-1318	748	9	.	.	PROPN
dti-1318	748	10	,	,	PUNCT
dti-1318	748	11	knigge	knigge	NOUN
dti-1318	748	12	,	,	PUNCT
dti-1318	748	13	m.	m.	NOUN
dti-1318	748	14	,	,	PUNCT
dti-1318	748	15	paul	paul	PROPN
dti-1318	748	16	,	,	PUNCT
dti-1318	748	17	d.a	d.a	PROPN
dti-1318	748	18	.	.	PROPN
dti-1318	748	19	,	,	PUNCT
dti-1318	748	20	kempf	kempf	PROPN
dti-1318	748	21	,	,	PUNCT
dti-1318	748	22	d.j	d.j	PROPN
dti-1318	748	23	.	.	PROPN
dti-1318	748	24	,	,	PUNCT
dti-1318	748	25	norbeck	norbeck	PROPN
dti-1318	748	26	,	,	PUNCT
dti-1318	748	27	d.w	d.w	PROPN
dti-1318	748	28	.	.	PROPN
dti-1318	748	29	and	and	CCONJ
dti-1318	748	30	swanstrom	swanstrom	PROPN
dti-1318	748	31	,	,	PUNCT
dti-1318	748	32	r.	r.	PROPN
dti-1318	748	33	1993	1993	NUM
dti-1318	748	34	.	.	PUNCT
dti-1318	749	1	partial	partial	ADJ
dti-1318	749	2	inhibition	inhibition	NOUN
dti-1318	749	3	of	of	ADP
dti-1318	749	4	the	the	DET
dti-1318	749	5	human	human	ADJ
dti-1318	749	6	immunodefi	immunodefi	PROPN
dti-1318	749	7	ciency	ciency	NOUN
dti-1318	749	8	virus	virus	NOUN
dti-1318	749	9	type	type	NOUN
dti-1318	749	10	1	1	NUM
dti-1318	749	11	protease	protease	NOUN
dti-1318	749	12	results	result	NOUN
dti-1318	749	13	in	in	ADP
dti-1318	749	14	aberrant	aberrant	ADJ
dti-1318	749	15	virus	virus	NOUN
dti-1318	749	16	assembly	assembly	NOUN
dti-1318	749	17	and	and	CCONJ
dti-1318	749	18	the	the	DET
dti-1318	749	19	formation	formation	NOUN
dti-1318	749	20	of	of	ADP
dti-1318	749	21	noninfectious	noninfectious	ADJ
dti-1318	749	22	particles	particle	NOUN
dti-1318	749	23	.	.	PUNCT
dti-1318	750	1	j.	j.	PROPN
dti-1318	750	2	virol	virol	PROPN
dti-1318	750	3	.	.	PUNCT
dti-1318	750	4	,	,	PUNCT
dti-1318	750	5	67	67	NUM
dti-1318	750	6	:	:	SYM
dti-1318	750	7	4050–4055	4050–4055	NUM
dti-1318	750	8	.	.	PUNCT
dti-1318	751	1	karacostas	karacostas	PROPN
dti-1318	751	2	,	,	PUNCT
dti-1318	751	3	v.	v.	ADV
dti-1318	751	4	,	,	PUNCT
dti-1318	751	5	wolffe	wolffe	NOUN
dti-1318	751	6	,	,	PUNCT
dti-1318	751	7	e.j	e.j	PROPN
dti-1318	751	8	.	.	PROPN
dti-1318	751	9	,	,	PUNCT
dti-1318	751	10	nagashima	nagashima	PROPN
dti-1318	751	11	,	,	PUNCT
dti-1318	751	12	k.	k.	PROPN
dti-1318	751	13	,	,	PUNCT
dti-1318	751	14	gonda	gonda	PROPN
dti-1318	751	15	,	,	PUNCT
dti-1318	751	16	m.a	m.a	PROPN
dti-1318	751	17	.	.	PROPN
dti-1318	751	18	and	and	CCONJ
dti-1318	751	19	moss	moss	PROPN
dti-1318	751	20	,	,	PUNCT
dti-1318	751	21	b.	b.	PROPN
dti-1318	751	22	1993	1993	NUM
dti-1318	751	23	.	.	PUNCT
dti-1318	752	1	overexpression	overexpression	NOUN
dti-1318	752	2	of	of	ADP
dti-1318	752	3	the	the	DET
dti-1318	752	4	hiv-1	hiv-1	ADJ
dti-1318	752	5	gag	gag	NOUN
dti-1318	752	6	-	-	PUNCT
dti-1318	752	7	pol	pol	NOUN
dti-1318	752	8	polyprotein	polyprotein	NOUN
dti-1318	752	9	results	result	NOUN
dti-1318	752	10	in	in	ADP
dti-1318	752	11	intracellular	intracellular	ADJ
dti-1318	752	12	activation	activation	NOUN
dti-1318	752	13	of	of	ADP
dti-1318	752	14	hiv-1	hiv-1	X
dti-1318	752	15	protease	protease	NOUN
dti-1318	752	16	and	and	CCONJ
dti-1318	752	17	inhibition	inhibition	NOUN
dti-1318	752	18	of	of	ADP
dti-1318	752	19	assembly	assembly	NOUN
dti-1318	752	20	and	and	CCONJ
dti-1318	752	21	budding	budding	NOUN
dti-1318	752	22	of	of	ADP
dti-1318	752	23	virus	virus	NOUN
dti-1318	752	24	-	-	PUNCT
dti-1318	752	25	like	like	ADJ
dti-1318	752	26	particles	particle	NOUN
dti-1318	752	27	.	.	PUNCT
dti-1318	753	1	virology	virology	NOUN
dti-1318	753	2	,	,	PUNCT
dti-1318	753	3	193:661–671	193:661–671	NUM
dti-1318	753	4	.	.	PUNCT
dti-1318	754	1	klimkait	klimkait	PROPN
dti-1318	754	2	,	,	PUNCT
dti-1318	754	3	t.	t.	PROPN
dti-1318	754	4	,	,	PUNCT
dti-1318	754	5	strebel	strebel	NOUN
dti-1318	754	6	,	,	PUNCT
dti-1318	754	7	k.	k.	PROPN
dti-1318	754	8	,	,	PUNCT
dti-1318	754	9	hoggan	hoggan	PROPN
dti-1318	754	10	,	,	PUNCT
dti-1318	754	11	m.d	m.d	PROPN
dti-1318	754	12	.	.	PROPN
dti-1318	754	13	,	,	PUNCT
dti-1318	754	14	martin	martin	PROPN
dti-1318	754	15	,	,	PUNCT
dti-1318	754	16	m.a	m.a	PROPN
dti-1318	754	17	.	.	PROPN
dti-1318	754	18	and	and	CCONJ
dti-1318	754	19	orenstein	orenstein	ADJ
dti-1318	754	20	,	,	PUNCT
dti-1318	754	21	j.m	j.m	PROPN
dti-1318	754	22	.	.	PROPN
dti-1318	754	23	1990	1990	NUM
dti-1318	754	24	.	.	PUNCT
dti-1318	755	1	the	the	DET
dti-1318	755	2	human	human	ADJ
dti-1318	755	3	immunodefi	immunodefi	PROPN
dti-1318	755	4	ciency	ciency	NOUN
dti-1318	755	5	virus	virus	NOUN
dti-1318	755	6	type	type	NOUN
dti-1318	755	7	1	1	NUM
dti-1318	755	8	-	-	PUNCT
dti-1318	755	9	specifi	specifi	NOUN
dti-1318	755	10	c	c	NOUN
dti-1318	755	11	protein	protein	NOUN
dti-1318	755	12	vpu	vpu	NOUN
dti-1318	755	13	is	be	AUX
dti-1318	755	14	required	require	VERB
dti-1318	755	15	for	for	ADP
dti-1318	755	16	effi	effi	PROPN
dti-1318	755	17	cient	cient	PROPN
dti-1318	755	18	virus	virus	NOUN
dti-1318	755	19	maturation	maturation	NOUN
dti-1318	755	20	and	and	CCONJ
dti-1318	755	21	release	release	NOUN
dti-1318	755	22	.	.	PUNCT
dti-1318	756	1	j.	j.	PROPN
dti-1318	756	2	virol	virol	PROPN
dti-1318	756	3	.	.	PUNCT
dti-1318	756	4	,	,	PUNCT
dti-1318	756	5	64:621–629	64:621–629	NUM
dti-1318	756	6	.	.	PUNCT
dti-1318	756	7	kohl	kohl	PROPN
dti-1318	756	8	,	,	PUNCT
dti-1318	756	9	n.e	n.e	PROPN
dti-1318	756	10	.	.	PROPN
dti-1318	756	11	,	,	PUNCT
dti-1318	756	12	emini	emini	PROPN
dti-1318	756	13	,	,	PUNCT
dti-1318	756	14	e.a	e.a	PROPN
dti-1318	756	15	.	.	PROPN
dti-1318	756	16	,	,	PUNCT
dti-1318	756	17	schleif	schleif	PROPN
dti-1318	756	18	,	,	PUNCT
dti-1318	756	19	w.a	w.a	PROPN
dti-1318	756	20	.	.	PROPN
dti-1318	756	21	,	,	PUNCT
dti-1318	756	22	davis	davis	PROPN
dti-1318	756	23	,	,	PUNCT
dti-1318	756	24	l.j	l.j	PROPN
dti-1318	756	25	.	.	PROPN
dti-1318	756	26	,	,	PUNCT
dti-1318	756	27	heimbach	heimbach	PROPN
dti-1318	756	28	,	,	PUNCT
dti-1318	756	29	j.c	j.c	PROPN
dti-1318	756	30	.	.	PROPN
dti-1318	756	31	,	,	PUNCT
dti-1318	756	32	dixon	dixon	PROPN
dti-1318	756	33	,	,	PUNCT
dti-1318	756	34	r.a	r.a	PROPN
dti-1318	756	35	.	.	PROPN
dti-1318	756	36	,	,	PUNCT
dti-1318	756	37	scolnick	scolnick	PROPN
dti-1318	756	38	,	,	PUNCT
dti-1318	756	39	e.m	e.m	PROPN
dti-1318	756	40	.	.	PROPN
dti-1318	756	41	and	and	CCONJ
dti-1318	756	42	sigal	sigal	ADJ
dti-1318	756	43	,	,	PUNCT
dti-1318	756	44	i.s	i.s	PROPN
dti-1318	756	45	.	.	PROPN
dti-1318	756	46	1988	1988	NUM
dti-1318	756	47	.	.	PUNCT
dti-1318	757	1	active	active	ADJ
dti-1318	757	2	human	human	ADJ
dti-1318	757	3	immunodefi	immunodefi	PROPN
dti-1318	757	4	ciency	ciency	NOUN
dti-1318	757	5	virus	virus	NOUN
dti-1318	757	6	protease	protease	NOUN
dti-1318	757	7	is	be	AUX
dti-1318	757	8	required	require	VERB
dti-1318	757	9	for	for	ADP
dti-1318	757	10	viral	viral	ADJ
dti-1318	757	11	infectivity	infectivity	NOUN
dti-1318	757	12	.	.	PUNCT
dti-1318	758	1	proc	proc	NOUN
dti-1318	758	2	.	.	PUNCT
dti-1318	759	1	natl	natl	PROPN
dti-1318	759	2	.	.	PUNCT
dti-1318	760	1	acad	acad	PROPN
dti-1318	760	2	.	.	PUNCT
dti-1318	761	1	sci	sci	PROPN
dti-1318	761	2	.	.	PUNCT
dti-1318	761	3	u.s.a	u.s.a	PROPN
dti-1318	761	4	.	.	PROPN
dti-1318	761	5	,	,	PUNCT
dti-1318	761	6	85:4686–4690	85:4686–4690	NUM
dti-1318	761	7	.	.	PUNCT
dti-1318	761	8	kohlstaedt	kohlstaedt	PROPN
dti-1318	761	9	,	,	PUNCT
dti-1318	761	10	l.a	l.a	PROPN
dti-1318	761	11	.	.	PROPN
dti-1318	761	12	,	,	PUNCT
dti-1318	761	13	wang	wang	PROPN
dti-1318	761	14	,	,	PUNCT
dti-1318	761	15	j.	j.	PROPN
dti-1318	761	16	,	,	PUNCT
dti-1318	761	17	friedman	friedman	PROPN
dti-1318	761	18	,	,	PUNCT
dti-1318	761	19	j.m	j.m	PROPN
dti-1318	761	20	.	.	PROPN
dti-1318	761	21	,	,	PUNCT
dti-1318	761	22	rice	rice	PROPN
dti-1318	761	23	,	,	PUNCT
dti-1318	761	24	p.a	p.a	PROPN
dti-1318	761	25	.	.	PROPN
dti-1318	761	26	and	and	CCONJ
dti-1318	761	27	steitz	steitz	PROPN
dti-1318	761	28	,	,	PUNCT
dti-1318	761	29	t.a	t.a	PROPN
dti-1318	761	30	.	.	PROPN
dti-1318	761	31	1992	1992	NUM
dti-1318	761	32	.	.	PUNCT
dti-1318	762	1	crystal	crystal	NOUN
dti-1318	762	2	structure	structure	NOUN
dti-1318	762	3	at	at	ADP
dti-1318	762	4	3.5	3.5	NUM
dti-1318	762	5	a	a	DET
dti-1318	762	6	resolution	resolution	NOUN
dti-1318	762	7	of	of	ADP
dti-1318	762	8	hiv-1	hiv-1	X
dti-1318	762	9	reverse	reverse	ADJ
dti-1318	762	10	transcriptase	transcriptase	NOUN
dti-1318	762	11	complexed	complexe	VERB
dti-1318	762	12	with	with	ADP
dti-1318	762	13	an	an	DET
dti-1318	762	14	inhibitor	inhibitor	NOUN
dti-1318	762	15	.	.	PUNCT
dti-1318	763	1	science	science	NOUN
dti-1318	763	2	,	,	PUNCT
dti-1318	763	3	256:1783–1790	256:1783–1790	NUM
dti-1318	763	4	.	.	PUNCT
dti-1318	763	5	kollmus	kollmus	PROPN
dti-1318	763	6	,	,	PUNCT
dti-1318	763	7	h.	h.	PROPN
dti-1318	763	8	,	,	PUNCT
dti-1318	763	9	honigman	honigman	PROPN
dti-1318	763	10	,	,	PUNCT
dti-1318	763	11	a.	a.	NOUN
dti-1318	763	12	,	,	PUNCT
dti-1318	763	13	panet	panet	NOUN
dti-1318	763	14	,	,	PUNCT
dti-1318	763	15	a.	a.	NOUN
dti-1318	763	16	and	and	CCONJ
dti-1318	763	17	hauser	hauser	PROPN
dti-1318	763	18	,	,	PUNCT
dti-1318	763	19	h.	h.	PROPN
dti-1318	763	20	1994	1994	NUM
dti-1318	763	21	.	.	PUNCT
dti-1318	764	1	the	the	DET
dti-1318	764	2	sequences	sequence	NOUN
dti-1318	764	3	of	of	ADP
dti-1318	764	4	and	and	CCONJ
dti-1318	764	5	distance	distance	NOUN
dti-1318	764	6	between	between	ADP
dti-1318	764	7	two	two	NUM
dti-1318	764	8	cis	cis	NOUN
dti-1318	764	9	-	-	PUNCT
dti-1318	764	10	acting	act	VERB
dti-1318	764	11	signals	signal	NOUN
dti-1318	764	12	determine	determine	VERB
dti-1318	764	13	the	the	DET
dti-1318	764	14	effi	effi	PROPN
dti-1318	764	15	ciency	ciency	NOUN
dti-1318	764	16	of	of	ADP
dti-1318	764	17	ribosomal	ribosomal	NOUN
dti-1318	764	18	frameshifting	frameshifting	NOUN
dti-1318	764	19	in	in	ADP
dti-1318	764	20	human	human	ADJ
dti-1318	764	21	immunodefi	immunodefi	PROPN
dti-1318	764	22	ciency	ciency	NOUN
dti-1318	764	23	virus	virus	NOUN
dti-1318	764	24	type	type	NOUN
dti-1318	764	25	1	1	NUM
dti-1318	764	26	and	and	CCONJ
dti-1318	764	27	human	human	PROPN
dti-1318	764	28	t	t	PROPN
dti-1318	764	29	-	-	PUNCT
dti-1318	764	30	cell	cell	NOUN
dti-1318	764	31	leukemia	leukemia	NOUN
dti-1318	764	32	virus	virus	NOUN
dti-1318	764	33	type	type	NOUN
dti-1318	764	34	ii	ii	PROPN
dti-1318	764	35	in	in	ADP
dti-1318	764	36	vivo	vivo	NOUN
dti-1318	764	37	.	.	PUNCT
dti-1318	765	1	j.	j.	PROPN
dti-1318	765	2	virol	virol	PROPN
dti-1318	765	3	.	.	PUNCT
dti-1318	765	4	,	,	PUNCT
dti-1318	765	5	68:6087–6091	68:6087–6091	X
dti-1318	765	6	.	.	PUNCT
dti-1318	766	1	krausslich	krausslich	PROPN
dti-1318	766	2	,	,	PUNCT
dti-1318	766	3	h.g	h.g	PROPN
dti-1318	766	4	.	.	PROPN
dti-1318	766	5	1991	1991	NUM
dti-1318	766	6	.	.	PUNCT
dti-1318	767	1	human	human	ADJ
dti-1318	767	2	immunodefi	immunodefi	PROPN
dti-1318	767	3	ciency	ciency	NOUN
dti-1318	767	4	virus	virus	NOUN
dti-1318	767	5	proteinase	proteinase	NOUN
dti-1318	767	6	dimer	dimer	NOUN
dti-1318	767	7	as	as	ADP
dti-1318	767	8	component	component	NOUN
dti-1318	767	9	of	of	ADP
dti-1318	767	10	the	the	DET
dti-1318	767	11	viral	viral	ADJ
dti-1318	767	12	polyprotein	polyprotein	NOUN
dti-1318	767	13	prevents	prevent	VERB
dti-1318	767	14	particle	particle	NOUN
dti-1318	767	15	assembly	assembly	NOUN
dti-1318	767	16	and	and	CCONJ
dti-1318	767	17	viral	viral	ADJ
dti-1318	767	18	infectivity	infectivity	NOUN
dti-1318	767	19	.	.	PUNCT
dti-1318	768	1	proc	proc	NOUN
dti-1318	768	2	.	.	PUNCT
dti-1318	769	1	natl	natl	PROPN
dti-1318	769	2	.	.	PUNCT
dti-1318	770	1	acad	acad	PROPN
dti-1318	770	2	.	.	PUNCT
dti-1318	771	1	sci	sci	PROPN
dti-1318	771	2	.	.	PUNCT
dti-1318	771	3	u.s.a	u.s.a	AUX
dti-1318	771	4	.	.	PROPN
dti-1318	771	5	,	,	PUNCT
dti-1318	771	6	88:3213–3217	88:3213–3217	NUM
dti-1318	771	7	.	.	PUNCT
dti-1318	771	8	langner	langner	PROPN
dti-1318	771	9	,	,	PUNCT
dti-1318	771	10	c.a	c.a	PROPN
dti-1318	771	11	.	.	PROPN
dti-1318	771	12	,	,	PUNCT
dti-1318	771	13	lodge	lodge	PROPN
dti-1318	771	14	,	,	PUNCT
dti-1318	771	15	j.k	j.k	PROPN
dti-1318	771	16	.	.	PROPN
dti-1318	771	17	,	,	PUNCT
dti-1318	771	18	travis	travis	PROPN
dti-1318	771	19	,	,	PUNCT
dti-1318	771	20	s.j	s.j	PROPN
dti-1318	771	21	.	.	PROPN
dti-1318	771	22	,	,	PUNCT
dti-1318	771	23	caldwell	caldwell	PROPN
dti-1318	771	24	,	,	PUNCT
dti-1318	771	25	j.e	j.e	PROPN
dti-1318	771	26	.	.	PROPN
dti-1318	771	27	,	,	PUNCT
dti-1318	771	28	lu	lu	PROPN
dti-1318	771	29	,	,	PUNCT
dti-1318	771	30	t.	t.	PROPN
dti-1318	771	31	,	,	PUNCT
dti-1318	771	32	li	li	PROPN
dti-1318	771	33	,	,	PUNCT
dti-1318	771	34	q.	q.	PROPN
dti-1318	771	35	,	,	PUNCT
dti-1318	771	36	bryant	bryant	PROPN
dti-1318	771	37	,	,	PUNCT
dti-1318	771	38	m.l	m.l	PROPN
dti-1318	771	39	.	.	PROPN
dti-1318	771	40	,	,	PUNCT
dti-1318	771	41	devadas	devadas	PROPN
dti-1318	771	42	,	,	PUNCT
dti-1318	771	43	b.	b.	PROPN
dti-1318	771	44	,	,	PUNCT
dti-1318	771	45	gokel	gokel	PROPN
dti-1318	771	46	,	,	PUNCT
dti-1318	771	47	g.w	g.w	PROPN
dti-1318	771	48	.	.	PROPN
dti-1318	771	49	,	,	PUNCT
dti-1318	771	50	kobayashi	kobayashi	PROPN
dti-1318	771	51	,	,	PUNCT
dti-1318	771	52	g.s	g.s	PROPN
dti-1318	771	53	.	.	PROPN
dti-1318	771	54	et	et	PROPN
dti-1318	771	55	al	al	PROPN
dti-1318	771	56	.	.	PROPN
dti-1318	771	57	1992	1992	NUM
dti-1318	771	58	.	.	PUNCT
dti-1318	772	1	4	4	NUM
dti-1318	772	2	-	-	PUNCT
dti-1318	772	3	oxatetradecanoic	oxatetradecanoic	ADJ
dti-1318	772	4	acid	acid	NOUN
dti-1318	772	5	is	be	AUX
dti-1318	772	6	fungicidal	fungicidal	NOUN
dti-1318	772	7	for	for	ADP
dti-1318	772	8	cryptococcus	cryptococcus	PROPN
dti-1318	772	9	neoformans	neoforman	NOUN
dti-1318	772	10	and	and	CCONJ
dti-1318	772	11	inhibits	inhibit	VERB
dti-1318	772	12	replication	replication	NOUN
dti-1318	772	13	of	of	ADP
dti-1318	772	14	human	human	ADJ
dti-1318	772	15	immunodefi	immunodefi	PROPN
dti-1318	772	16	ciency	ciency	PROPN
dti-1318	772	17	virus	virus	PROPN
dti-1318	772	18	i.	i.	PROPN
dti-1318	772	19	j.	j.	PROPN
dti-1318	772	20	biol	biol	PROPN
dti-1318	772	21	.	.	PUNCT
dti-1318	773	1	chem	chem	PROPN
dti-1318	773	2	.	.	PUNCT
dti-1318	773	3	,	,	PUNCT
dti-1318	774	1	267:17159–17169	267:17159–17169	NUM
dti-1318	774	2	.	.	PUNCT
dti-1318	774	3	lanman	lanman	PROPN
dti-1318	774	4	,	,	PUNCT
dti-1318	774	5	j.	j.	PROPN
dti-1318	774	6	,	,	PUNCT
dti-1318	774	7	lam	lam	PROPN
dti-1318	774	8	,	,	PUNCT
dti-1318	774	9	t.t	t.t	PROPN
dti-1318	774	10	.	.	PROPN
dti-1318	774	11	,	,	PUNCT
dti-1318	774	12	barnes	barnes	PROPN
dti-1318	774	13	,	,	PUNCT
dti-1318	774	14	s.	s.	PROPN
dti-1318	774	15	,	,	PUNCT
dti-1318	774	16	sakalian	sakalian	NOUN
dti-1318	774	17	,	,	PUNCT
dti-1318	774	18	m.	m.	NOUN
dti-1318	774	19	,	,	PUNCT
dti-1318	774	20	emmett	emmett	PROPN
dti-1318	774	21	,	,	PUNCT
dti-1318	774	22	m.r	m.r	PROPN
dti-1318	774	23	.	.	PROPN
dti-1318	774	24	,	,	PUNCT
dti-1318	774	25	marshall	marshall	PROPN
dti-1318	774	26	,	,	PUNCT
dti-1318	774	27	a.g	a.g	PROPN
dti-1318	774	28	.	.	PROPN
dti-1318	774	29	and	and	CCONJ
dti-1318	774	30	prevelige	prevelige	PROPN
dti-1318	774	31	,	,	PUNCT
dti-1318	774	32	p.e	p.e	PROPN
dti-1318	774	33	.	.	PROPN
dti-1318	774	34	,	,	PUNCT
dti-1318	774	35	jr	jr	PROPN
dti-1318	774	36	.	.	PROPN
dti-1318	774	37	2003	2003	NUM
dti-1318	774	38	.	.	PUNCT
dti-1318	775	1	identifi	identifi	PROPN
dti-1318	775	2	cation	cation	NOUN
dti-1318	775	3	of	of	ADP
dti-1318	775	4	novel	novel	ADJ
dti-1318	775	5	interactions	interaction	NOUN
dti-1318	775	6	in	in	ADP
dti-1318	775	7	hiv-1	hiv-1	PUNCT
dti-1318	775	8	capsid	capsid	ADJ
dti-1318	775	9	protein	protein	NOUN
dti-1318	775	10	assembly	assembly	NOUN
dti-1318	775	11	by	by	ADP
dti-1318	775	12	high	high	ADJ
dti-1318	775	13	-	-	PUNCT
dti-1318	775	14	resolution	resolution	NOUN
dti-1318	775	15	mass	mass	NOUN
dti-1318	775	16	spectrometry	spectrometry	NOUN
dti-1318	775	17	.	.	PUNCT
dti-1318	776	1	j.	j.	PROPN
dti-1318	776	2	mol	mol	PROPN
dti-1318	776	3	.	.	PUNCT
dti-1318	777	1	biol	biol	PROPN
dti-1318	777	2	.	.	PUNCT
dti-1318	777	3	,	,	PUNCT
dti-1318	777	4	325:759–772	325:759–772	NUM
dti-1318	777	5	.	.	PUNCT
dti-1318	778	1	lapadat	lapadat	ADJ
dti-1318	778	2	-	-	PUNCT
dti-1318	778	3	tapolsky	tapolsky	ADJ
dti-1318	778	4	,	,	PUNCT
dti-1318	778	5	m.	m.	NOUN
dti-1318	778	6	,	,	PUNCT
dti-1318	778	7	de	de	X
dti-1318	778	8	rocquigny	rocquigny	PROPN
dti-1318	778	9	,	,	PUNCT
dti-1318	778	10	h.	h.	PROPN
dti-1318	778	11	,	,	PUNCT
dti-1318	778	12	van	van	PROPN
dti-1318	778	13	gent	gent	PROPN
dti-1318	778	14	,	,	PUNCT
dti-1318	778	15	d.	d.	PROPN
dti-1318	778	16	,	,	PUNCT
dti-1318	778	17	roques	roque	NOUN
dti-1318	778	18	,	,	PUNCT
dti-1318	778	19	b.	b.	PROPN
dti-1318	778	20	,	,	PUNCT
dti-1318	778	21	plasterk	plasterk	PROPN
dti-1318	778	22	,	,	PUNCT
dti-1318	778	23	r.	r.	PROPN
dti-1318	778	24	and	and	CCONJ
dti-1318	778	25	darlix	darlix	ADJ
dti-1318	778	26	,	,	PUNCT
dti-1318	778	27	j.l	j.l	PROPN
dti-1318	778	28	.	.	PROPN
dti-1318	778	29	1993	1993	NUM
dti-1318	778	30	.	.	PUNCT
dti-1318	779	1	interactions	interaction	NOUN
dti-1318	779	2	between	between	ADP
dti-1318	779	3	hiv-1	hiv-1	X
dti-1318	779	4	nucleocapsid	nucleocapsid	ADJ
dti-1318	779	5	protein	protein	NOUN
dti-1318	779	6	and	and	CCONJ
dti-1318	779	7	viral	viral	ADJ
dti-1318	779	8	dna	dna	NOUN
dti-1318	779	9	may	may	AUX
dti-1318	779	10	have	have	VERB
dti-1318	779	11	important	important	ADJ
dti-1318	779	12	functions	function	NOUN
dti-1318	779	13	in	in	ADP
dti-1318	779	14	the	the	DET
dti-1318	779	15	viral	viral	ADJ
dti-1318	779	16	life	life	NOUN
dti-1318	779	17	cycle	cycle	NOUN
dti-1318	779	18	.	.	PUNCT
dti-1318	780	1	nucleic	nucleic	ADJ
dti-1318	780	2	acids	acid	NOUN
dti-1318	780	3	res	re	NOUN
dti-1318	780	4	.	.	PUNCT
dti-1318	780	5	,	,	PUNCT
dti-1318	780	6	21:831–839	21:831–839	PROPN
dti-1318	780	7	.	.	PUNCT
dti-1318	781	1	li	li	PROPN
dti-1318	781	2	,	,	PUNCT
dti-1318	781	3	f.	f.	PROPN
dti-1318	781	4	,	,	PUNCT
dti-1318	781	5	goila	goila	ADJ
dti-1318	781	6	-	-	PUNCT
dti-1318	781	7	gaur	gaur	NOUN
dti-1318	781	8	,	,	PUNCT
dti-1318	781	9	r.	r.	PROPN
dti-1318	781	10	,	,	PUNCT
dti-1318	781	11	salzwedel	salzwedel	PROPN
dti-1318	781	12	,	,	PUNCT
dti-1318	781	13	k.	k.	PROPN
dti-1318	781	14	,	,	PUNCT
dti-1318	781	15	kilgore	kilgore	PROPN
dti-1318	781	16	,	,	PUNCT
dti-1318	781	17	n.r	n.r	PROPN
dti-1318	781	18	.	.	PROPN
dti-1318	781	19	,	,	PUNCT
dti-1318	781	20	reddick	reddick	PROPN
dti-1318	781	21	,	,	PUNCT
dti-1318	781	22	m.	m.	NOUN
dti-1318	781	23	,	,	PUNCT
dti-1318	781	24	matallana	matallana	PROPN
dti-1318	781	25	,	,	PUNCT
dti-1318	781	26	c.	c.	PROPN
dti-1318	781	27	,	,	PUNCT
dti-1318	781	28	castillo	castillo	PROPN
dti-1318	781	29	,	,	PUNCT
dti-1318	781	30	a.	a.	NOUN
dti-1318	781	31	,	,	PUNCT
dti-1318	781	32	zoumplis	zoumplis	PROPN
dti-1318	781	33	,	,	PUNCT
dti-1318	781	34	d.	d.	PROPN
dti-1318	781	35	,	,	PUNCT
dti-1318	781	36	martin	martin	PROPN
dti-1318	781	37	,	,	PUNCT
dti-1318	781	38	d.e	d.e	PROPN
dti-1318	781	39	.	.	PROPN
dti-1318	781	40	,	,	PUNCT
dti-1318	781	41	orenstein	orenstein	PROPN
dti-1318	781	42	,	,	PUNCT
dti-1318	781	43	j.m	j.m	PROPN
dti-1318	781	44	.	.	PROPN
dti-1318	781	45	,	,	PUNCT
dti-1318	781	46	allaway	allaway	PROPN
dti-1318	781	47	,	,	PUNCT
dti-1318	781	48	g.p	g.p	PROPN
dti-1318	781	49	.	.	PROPN
dti-1318	781	50	,	,	PUNCT
dti-1318	781	51	freed	free	VERB
dti-1318	781	52	,	,	PUNCT
dti-1318	781	53	e.o	e.o	PROPN
dti-1318	781	54	.	.	PROPN
dti-1318	781	55	and	and	CCONJ
dti-1318	781	56	wild	wild	PROPN
dti-1318	781	57	,	,	PUNCT
dti-1318	781	58	c.t	c.t	PROPN
dti-1318	781	59	.	.	PROPN
dti-1318	781	60	2003	2003	NUM
dti-1318	781	61	.	.	PUNCT
dti-1318	782	1	pa-457	pa-457	PROPN
dti-1318	782	2	:	:	PUNCT
dti-1318	782	3	a	a	DET
dti-1318	782	4	potent	potent	ADJ
dti-1318	782	5	hiv	hiv	PROPN
dti-1318	782	6	inhibitor	inhibitor	NOUN
dti-1318	782	7	that	that	PRON
dti-1318	782	8	disrupts	disrupt	VERB
dti-1318	782	9	core	core	NOUN
dti-1318	782	10	condensation	condensation	NOUN
dti-1318	782	11	by	by	ADP
dti-1318	782	12	targeting	target	VERB
dti-1318	782	13	a	a	DET
dti-1318	782	14	late	late	ADJ
dti-1318	782	15	step	step	NOUN
dti-1318	782	16	in	in	ADP
dti-1318	782	17	gag	gag	NOUN
dti-1318	782	18	processing	processing	NOUN
dti-1318	782	19	.	.	PUNCT
dti-1318	783	1	proc	proc	PROPN
dti-1318	783	2	.	.	PUNCT
dti-1318	784	1	natl	natl	PROPN
dti-1318	784	2	.	.	PUNCT
dti-1318	785	1	acad	acad	PROPN
dti-1318	785	2	.	.	PUNCT
dti-1318	786	1	sci	sci	PROPN
dti-1318	786	2	.	.	PUNCT
dti-1318	786	3	u.s.a	u.s.a	PROPN
dti-1318	786	4	.	.	PROPN
dti-1318	786	5	,	,	PUNCT
dti-1318	786	6	100:13555–13560	100:13555–13560	PROPN
dti-1318	786	7	.	.	PUNCT
dti-1318	787	1	li	li	PROPN
dti-1318	787	2	,	,	PUNCT
dti-1318	787	3	l.	l.	PROPN
dti-1318	787	4	,	,	PUNCT
dti-1318	787	5	li	li	PROPN
dti-1318	787	6	,	,	PUNCT
dti-1318	787	7	h.s	h.s	PROPN
dti-1318	787	8	.	.	PROPN
dti-1318	787	9	,	,	PUNCT
dti-1318	787	10	pauza	pauza	PROPN
dti-1318	787	11	,	,	PUNCT
dti-1318	787	12	c.d	c.d	PROPN
dti-1318	787	13	.	.	PROPN
dti-1318	787	14	,	,	PUNCT
dti-1318	787	15	bukrinsky	bukrinsky	NOUN
dti-1318	787	16	,	,	PUNCT
dti-1318	787	17	m.	m.	NOUN
dti-1318	787	18	and	and	CCONJ
dti-1318	787	19	zhao	zhao	PROPN
dti-1318	787	20	,	,	PUNCT
dti-1318	787	21	r.y	r.y	PROPN
dti-1318	787	22	.	.	PROPN
dti-1318	787	23	2005	2005	NUM
dti-1318	787	24	.	.	PUNCT
dti-1318	788	1	roles	role	NOUN
dti-1318	788	2	of	of	ADP
dti-1318	788	3	hiv-1	hiv-1	ADJ
dti-1318	788	4	auxiliary	auxiliary	ADJ
dti-1318	788	5	proteins	protein	NOUN
dti-1318	788	6	in	in	ADP
dti-1318	788	7	viral	viral	ADJ
dti-1318	788	8	pathogenesis	pathogenesis	NOUN
dti-1318	788	9	and	and	CCONJ
dti-1318	788	10	host	host	NOUN
dti-1318	788	11	-	-	PUNCT
dti-1318	788	12	pathogen	pathogen	NOUN
dti-1318	788	13	interactions	interaction	NOUN
dti-1318	788	14	.	.	PUNCT
dti-1318	789	1	cell	cell	NOUN
dti-1318	789	2	res	re	NOUN
dti-1318	789	3	.	.	PUNCT
dti-1318	789	4	,	,	PUNCT
dti-1318	789	5	15:923–934	15:923–934	NUM
dti-1318	789	6	.	.	PUNCT
dti-1318	790	1	li	li	PROPN
dti-1318	790	2	,	,	PUNCT
dti-1318	790	3	s.	s.	PROPN
dti-1318	790	4	,	,	PUNCT
dti-1318	790	5	hill	hill	PROPN
dti-1318	790	6	,	,	PUNCT
dti-1318	790	7	c.p	c.p	PROPN
dti-1318	790	8	.	.	PROPN
dti-1318	790	9	,	,	PUNCT
dti-1318	790	10	sundquist	sundquist	PROPN
dti-1318	790	11	,	,	PUNCT
dti-1318	790	12	w.i	w.i	PROPN
dti-1318	790	13	.	.	PROPN
dti-1318	790	14	and	and	CCONJ
dti-1318	790	15	finch	finch	PROPN
dti-1318	790	16	,	,	PUNCT
dti-1318	790	17	j.t	j.t	PROPN
dti-1318	790	18	.	.	PROPN
dti-1318	790	19	2000	2000	NUM
dti-1318	790	20	.	.	PUNCT
dti-1318	791	1	image	image	NOUN
dti-1318	791	2	reconstructions	reconstruction	NOUN
dti-1318	791	3	of	of	ADP
dti-1318	791	4	helical	helical	ADJ
dti-1318	791	5	assemblies	assembly	NOUN
dti-1318	791	6	of	of	ADP
dti-1318	791	7	the	the	DET
dti-1318	791	8	hiv-1	hiv-1	X
dti-1318	791	9	ca	ca	NOUN
dti-1318	791	10	protein	protein	NOUN
dti-1318	791	11	.	.	PUNCT
dti-1318	792	1	nature	nature	NOUN
dti-1318	792	2	,	,	PUNCT
dti-1318	792	3	407:409–413	407:409–413	NUM
dti-1318	792	4	.	.	PUNCT
dti-1318	793	1	liao	liao	PROPN
dti-1318	793	2	,	,	PUNCT
dti-1318	793	3	w.h	w.h	PROPN
dti-1318	793	4	.	.	PROPN
dti-1318	793	5	and	and	CCONJ
dti-1318	793	6	wang	wang	PROPN
dti-1318	793	7	,	,	PUNCT
dti-1318	793	8	c.t	c.t	PROPN
dti-1318	793	9	.	.	PROPN
dti-1318	793	10	2004	2004	NUM
dti-1318	793	11	.	.	PUNCT
dti-1318	794	1	characterization	characterization	NOUN
dti-1318	794	2	of	of	ADP
dti-1318	794	3	human	human	ADJ
dti-1318	794	4	immunodefi	immunodefi	PROPN
dti-1318	794	5	ciency	ciency	NOUN
dti-1318	794	6	virus	virus	NOUN
dti-1318	794	7	type	type	NOUN
dti-1318	794	8	1	1	NUM
dti-1318	794	9	pr160	pr160	PROPN
dti-1318	794	10	gag	gag	NOUN
dti-1318	794	11	-	-	PUNCT
dti-1318	794	12	pol	pol	NOUN
dti-1318	794	13	mutants	mutant	NOUN
dti-1318	794	14	with	with	ADP
dti-1318	794	15	truncations	truncation	NOUN
dti-1318	794	16	downstream	downstream	ADV
dti-1318	794	17	of	of	ADP
dti-1318	794	18	the	the	DET
dti-1318	794	19	protease	protease	NOUN
dti-1318	794	20	domain	domain	NOUN
dti-1318	794	21	.	.	PUNCT
dti-1318	795	1	virology	virology	NOUN
dti-1318	795	2	,	,	PUNCT
dti-1318	795	3	329:180–188	329:180–188	NUM
dti-1318	795	4	.	.	PUNCT
dti-1318	796	1	lindwasser	lindwasser	PROPN
dti-1318	796	2	,	,	PUNCT
dti-1318	796	3	o.w	o.w	PROPN
dti-1318	796	4	.	.	PROPN
dti-1318	796	5	and	and	CCONJ
dti-1318	796	6	resh	resh	PROPN
dti-1318	796	7	,	,	PUNCT
dti-1318	796	8	m.d	m.d	PROPN
dti-1318	796	9	.	.	PROPN
dti-1318	796	10	2002	2002	NUM
dti-1318	796	11	.	.	PUNCT
dti-1318	797	1	myristoylation	myristoylation	NOUN
dti-1318	797	2	as	as	ADP
dti-1318	797	3	a	a	DET
dti-1318	797	4	target	target	NOUN
dti-1318	797	5	for	for	ADP
dti-1318	797	6	inhibiting	inhibit	VERB
dti-1318	797	7	hiv	hiv	PROPN
dti-1318	797	8	assembly	assembly	NOUN
dti-1318	797	9	:	:	PUNCT
dti-1318	797	10	unsaturated	unsaturated	ADJ
dti-1318	797	11	fatty	fatty	NOUN
dti-1318	797	12	acids	acid	NOUN
dti-1318	797	13	block	block	VERB
dti-1318	797	14	viral	viral	ADJ
dti-1318	797	15	budding	budding	NOUN
dti-1318	797	16	.	.	PUNCT
dti-1318	798	1	proc	proc	NOUN
dti-1318	798	2	.	.	PUNCT
dti-1318	799	1	natl	natl	PROPN
dti-1318	799	2	.	.	PUNCT
dti-1318	800	1	acad	acad	PROPN
dti-1318	800	2	.	.	PUNCT
dti-1318	801	1	sci	sci	PROPN
dti-1318	801	2	.	.	PUNCT
dti-1318	801	3	u.s.a	u.s.a	PROPN
dti-1318	801	4	.	.	PROPN
dti-1318	801	5	,	,	PUNCT
dti-1318	801	6	99:13037–13042	99:13037–13042	NUM
dti-1318	801	7	.	.	PUNCT
dti-1318	802	1	liu	liu	PROPN
dti-1318	802	2	,	,	PUNCT
dti-1318	802	3	f.	f.	PROPN
dti-1318	802	4	,	,	PUNCT
dti-1318	802	5	stephen	stephen	PROPN
dti-1318	802	6	,	,	PUNCT
dti-1318	802	7	a.g	a.g	PROPN
dti-1318	802	8	.	.	PROPN
dti-1318	802	9	,	,	PUNCT
dti-1318	802	10	adamson	adamson	PROPN
dti-1318	802	11	,	,	PUNCT
dti-1318	802	12	c.s	c.s	PROPN
dti-1318	802	13	.	.	PROPN
dti-1318	802	14	,	,	PUNCT
dti-1318	802	15	gousset	gousset	VERB
dti-1318	802	16	,	,	PUNCT
dti-1318	802	17	k.	k.	PROPN
dti-1318	802	18	,	,	PUNCT
dti-1318	802	19	aman	aman	PROPN
dti-1318	802	20	,	,	PUNCT
dti-1318	802	21	m.j	m.j	PROPN
dti-1318	802	22	.	.	PROPN
dti-1318	802	23	,	,	PUNCT
dti-1318	802	24	freed	free	VERB
dti-1318	802	25	,	,	PUNCT
dti-1318	802	26	e.o	e.o	PROPN
dti-1318	802	27	.	.	PROPN
dti-1318	802	28	,	,	PUNCT
dti-1318	802	29	fisher	fisher	PROPN
dti-1318	802	30	,	,	PUNCT
dti-1318	802	31	r.j	r.j	PROPN
dti-1318	802	32	.	.	PROPN
dti-1318	802	33	and	and	CCONJ
dti-1318	802	34	burke	burke	PROPN
dti-1318	802	35	,	,	PUNCT
dti-1318	802	36	t.r	t.r	PROPN
dti-1318	802	37	.	.	PROPN
dti-1318	802	38	,	,	PUNCT
dti-1318	802	39	jr	jr	PROPN
dti-1318	802	40	.	.	PROPN
dti-1318	802	41	2006	2006	NUM
dti-1318	802	42	.	.	PUNCT
dti-1318	803	1	hydrazoneand	hydrazoneand	PROPN
dti-1318	803	2	hydrazidecontaining	hydrazidecontaining	PROPN
dti-1318	803	3	n	n	CCONJ
dti-1318	803	4	-	-	PUNCT
dti-1318	803	5	substituted	substitute	VERB
dti-1318	803	6	glycines	glycine	NOUN
dti-1318	803	7	as	as	ADP
dti-1318	803	8	peptoid	peptoid	ADJ
dti-1318	803	9	surrogates	surrogate	NOUN
dti-1318	803	10	for	for	ADP
dti-1318	803	11	expedited	expedite	VERB
dti-1318	803	12	library	library	ADJ
dti-1318	803	13	synthesis	synthesis	NOUN
dti-1318	803	14	:	:	PUNCT
dti-1318	803	15	application	application	NOUN
dti-1318	803	16	to	to	ADP
dti-1318	803	17	the	the	DET
dti-1318	803	18	preparation	preparation	NOUN
dti-1318	803	19	of	of	ADP
dti-1318	803	20	tsg101	tsg101	PROPN
dti-1318	803	21	-	-	PUNCT
dti-1318	803	22	directed	direct	VERB
dti-1318	803	23	hiv-1	hiv-1	ADJ
dti-1318	803	24	budding	bud	VERB
dti-1318	803	25	antagonists	antagonist	NOUN
dti-1318	803	26	.	.	PUNCT
dti-1318	804	1	org	org	PROPN
dti-1318	804	2	.	.	PUNCT
dti-1318	805	1	lett	lett	PROPN
dti-1318	805	2	.	.	PROPN
dti-1318	805	3	,	,	PUNCT
dti-1318	805	4	8:5165–5168	8:5165–5168	NUM
dti-1318	805	5	.	.	PUNCT
dti-1318	805	6	louis	louis	PROPN
dti-1318	805	7	,	,	PUNCT
dti-1318	805	8	j.m	j.m	PROPN
dti-1318	805	9	.	.	PROPN
dti-1318	805	10	,	,	PUNCT
dti-1318	805	11	clore	clore	PROPN
dti-1318	805	12	,	,	PUNCT
dti-1318	805	13	g.m	g.m	PROPN
dti-1318	805	14	.	.	PROPN
dti-1318	805	15	and	and	CCONJ
dti-1318	805	16	gronenborn	gronenborn	VERB
dti-1318	805	17	,	,	PUNCT
dti-1318	805	18	a.m.	a.m.	NOUN
dti-1318	805	19	1999	1999	NUM
dti-1318	805	20	.	.	PUNCT
dti-1318	806	1	autoprocessing	autoprocesse	VERB
dti-1318	806	2	of	of	ADP
dti-1318	806	3	hiv-1	hiv-1	X
dti-1318	806	4	protease	protease	NOUN
dti-1318	806	5	is	be	AUX
dti-1318	806	6	tightly	tightly	ADV
dti-1318	806	7	coupled	couple	VERB
dti-1318	806	8	to	to	ADP
dti-1318	806	9	protein	protein	NOUN
dti-1318	806	10	folding	folding	NOUN
dti-1318	806	11	.	.	PUNCT
dti-1318	807	1	nat	nat	NOUN
dti-1318	807	2	.	.	PUNCT
dti-1318	807	3	struct	struct	NOUN
dti-1318	807	4	.	.	PUNCT
dti-1318	808	1	biol	biol	PROPN
dti-1318	808	2	.	.	PUNCT
dti-1318	808	3	,	,	PUNCT
dti-1318	808	4	6:868–875	6:868–875	PROPN
dti-1318	808	5	.	.	PUNCT
dti-1318	809	1	lu	lu	PROPN
dti-1318	809	2	,	,	PUNCT
dti-1318	809	3	q.	q.	PROPN
dti-1318	809	4	,	,	PUNCT
dti-1318	809	5	hope	hope	PROPN
dti-1318	809	6	,	,	PUNCT
dti-1318	809	7	l.w	l.w	PROPN
dti-1318	809	8	.	.	PROPN
dti-1318	809	9	,	,	PUNCT
dti-1318	809	10	brasch	brasch	PROPN
dti-1318	809	11	,	,	PUNCT
dti-1318	809	12	m.	m.	NOUN
dti-1318	809	13	,	,	PUNCT
dti-1318	809	14	reinhard	reinhard	PROPN
dti-1318	809	15	,	,	PUNCT
dti-1318	809	16	c.	c.	PROPN
dti-1318	809	17	and	and	CCONJ
dti-1318	809	18	cohen	cohen	PROPN
dti-1318	809	19	,	,	PUNCT
dti-1318	809	20	s.n	s.n	PROPN
dti-1318	809	21	.	.	PROPN
dti-1318	809	22	2003	2003	NUM
dti-1318	809	23	.	.	PUNCT
dti-1318	810	1	tsg101	tsg101	NOUN
dti-1318	810	2	interaction	interaction	NOUN
dti-1318	810	3	with	with	ADP
dti-1318	810	4	hrs	hrs	NOUN
dti-1318	810	5	mediates	mediate	NOUN
dti-1318	810	6	endosomal	endosomal	ADJ
dti-1318	810	7	traffi	traffi	PROPN
dti-1318	810	8	cking	cke	VERB
dti-1318	810	9	and	and	CCONJ
dti-1318	810	10	receptor	receptor	VERB
dti-1318	810	11	down	down	ADP
dti-1318	810	12	-	-	PUNCT
dti-1318	810	13	regulation	regulation	NOUN
dti-1318	810	14	.	.	PUNCT
dti-1318	811	1	proc	proc	PROPN
dti-1318	811	2	.	.	PUNCT
dti-1318	812	1	natl	natl	PROPN
dti-1318	812	2	.	.	PUNCT
dti-1318	813	1	acad	acad	PROPN
dti-1318	813	2	.	.	PUNCT
dti-1318	814	1	sci	sci	PROPN
dti-1318	814	2	.	.	PROPN
dti-1318	814	3	u.s.a	u.s.a	PROPN
dti-1318	814	4	,	,	PUNCT
dti-1318	814	5	100:7626–7631	100:7626–7631	NUM
dti-1318	814	6	.	.	PUNCT
dti-1318	814	7	makhija	makhija	NOUN
dti-1318	814	8	,	,	PUNCT
dti-1318	814	9	m.t	m.t	PROPN
dti-1318	814	10	.	.	PROPN
dti-1318	814	11	2006	2006	NUM
dti-1318	814	12	.	.	PUNCT
dti-1318	815	1	designing	design	VERB
dti-1318	815	2	hiv	hiv	PROPN
dti-1318	815	3	integrase	integrase	VERB
dti-1318	815	4	inhibitors	inhibitor	NOUN
dti-1318	815	5	--	--	PUNCT
dti-1318	815	6	shooting	shoot	VERB
dti-1318	815	7	the	the	DET
dti-1318	815	8	last	last	ADJ
dti-1318	815	9	arrow	arrow	NOUN
dti-1318	815	10	.	.	PUNCT
dti-1318	816	1	curr	curr	AUX
dti-1318	816	2	.	.	PUNCT
dti-1318	816	3	med	med	PROPN
dti-1318	816	4	.	.	PROPN
dti-1318	816	5	chem	chem	PROPN
dti-1318	816	6	.	.	PUNCT
dti-1318	816	7	,	,	PUNCT
dti-1318	817	1	13:2429–2441	13:2429–2441	NUM
dti-1318	817	2	.	.	PUNCT
dti-1318	818	1	mammano	mammano	PROPN
dti-1318	818	2	,	,	PUNCT
dti-1318	818	3	f.	f.	PROPN
dti-1318	818	4	,	,	PUNCT
dti-1318	818	5	ohagen	ohagen	PROPN
dti-1318	818	6	,	,	PUNCT
dti-1318	818	7	a.	a.	NOUN
dti-1318	818	8	,	,	PUNCT
dti-1318	818	9	hoglund	hoglund	PROPN
dti-1318	818	10	,	,	PUNCT
dti-1318	818	11	s.	s.	PROPN
dti-1318	818	12	and	and	CCONJ
dti-1318	818	13	gottlinger	gottlinger	PROPN
dti-1318	818	14	,	,	PUNCT
dti-1318	818	15	h.g	h.g	PROPN
dti-1318	818	16	.	.	PROPN
dti-1318	818	17	1994	1994	NUM
dti-1318	818	18	.	.	PUNCT
dti-1318	819	1	role	role	NOUN
dti-1318	819	2	of	of	ADP
dti-1318	819	3	the	the	DET
dti-1318	819	4	major	major	ADJ
dti-1318	819	5	homology	homology	NOUN
dti-1318	819	6	region	region	NOUN
dti-1318	819	7	of	of	ADP
dti-1318	819	8	human	human	ADJ
dti-1318	819	9	immunodefi	immunodefi	PROPN
dti-1318	819	10	ciency	ciency	NOUN
dti-1318	819	11	virus	virus	NOUN
dti-1318	819	12	type	type	NOUN
dti-1318	819	13	1	1	NUM
dti-1318	819	14	in	in	ADP
dti-1318	819	15	virion	virion	NOUN
dti-1318	819	16	morphogenesis	morphogenesis	NOUN
dti-1318	819	17	.	.	PUNCT
dti-1318	820	1	j.	j.	PROPN
dti-1318	820	2	virol	virol	PROPN
dti-1318	820	3	.	.	PUNCT
dti-1318	820	4	,	,	PUNCT
dti-1318	820	5	68:4927–4936	68:4927–4936	NUM
dti-1318	820	6	.	.	NOUN
dti-1318	820	7	179	179	NUM
dti-1318	820	8	targeting	target	VERB
dti-1318	820	9	the	the	DET
dti-1318	820	10	late	late	ADJ
dti-1318	820	11	stages	stage	NOUN
dti-1318	820	12	of	of	ADP
dti-1318	820	13	hiv-1	hiv-1	X
dti-1318	820	14	replication	replication	NOUN
dti-1318	820	15	drug	drug	NOUN
dti-1318	820	16	target	target	NOUN
dti-1318	820	17	insights	insight	NOUN
dti-1318	820	18	2007	2007	NUM
dti-1318	820	19	:	:	PUNCT
dti-1318	820	20	2	2	NUM
dti-1318	820	21	manfredi	manfredi	PROPN
dti-1318	820	22	,	,	PUNCT
dti-1318	820	23	r.	r.	PROPN
dti-1318	820	24	and	and	CCONJ
dti-1318	820	25	sabbatani	sabbatani	PROPN
dti-1318	820	26	,	,	PUNCT
dti-1318	820	27	s.	s.	PROPN
dti-1318	820	28	2006	2006	NUM
dti-1318	820	29	.	.	PUNCT
dti-1318	821	1	a	a	DET
dti-1318	821	2	novel	novel	ADJ
dti-1318	821	3	antiretroviral	antiretroviral	ADJ
dti-1318	821	4	class	class	NOUN
dti-1318	821	5	(	(	PUNCT
dti-1318	821	6	fusion	fusion	NOUN
dti-1318	821	7	inhibitors	inhibitor	NOUN
dti-1318	821	8	)	)	PUNCT
dti-1318	821	9	in	in	ADP
dti-1318	821	10	the	the	DET
dti-1318	821	11	management	management	NOUN
dti-1318	821	12	of	of	ADP
dti-1318	821	13	hiv	hiv	PROPN
dti-1318	821	14	infection	infection	NOUN
dti-1318	821	15	.	.	PUNCT
dti-1318	822	1	present	present	ADJ
dti-1318	822	2	features	feature	NOUN
dti-1318	822	3	and	and	CCONJ
dti-1318	822	4	future	future	ADJ
dti-1318	822	5	perspectives	perspective	NOUN
dti-1318	822	6	of	of	ADP
dti-1318	822	7	enfuvirtide	enfuvirtide	ADJ
dti-1318	822	8	(	(	PUNCT
dti-1318	822	9	t-20	t-20	PROPN
dti-1318	822	10	)	)	PUNCT
dti-1318	822	11	.	.	PUNCT
dti-1318	823	1	curr	curr	AUX
dti-1318	823	2	.	.	PUNCT
dti-1318	823	3	med	med	PROPN
dti-1318	823	4	.	.	PROPN
dti-1318	823	5	chem	chem	PROPN
dti-1318	823	6	.	.	PUNCT
dti-1318	823	7	,	,	PUNCT
dti-1318	823	8	13	13	NUM
dti-1318	823	9	:	:	PUNCT
dti-1318	823	10	2369–2384	2369–2384	NUM
dti-1318	823	11	.	.	PUNCT
dti-1318	824	1	maroun	maroun	PROPN
dti-1318	824	2	,	,	PUNCT
dti-1318	824	3	r.g	r.g	PROPN
dti-1318	824	4	.	.	PROPN
dti-1318	824	5	,	,	PUNCT
dti-1318	824	6	gayet	gayet	PROPN
dti-1318	824	7	,	,	PUNCT
dti-1318	824	8	s.	s.	PROPN
dti-1318	824	9	,	,	PUNCT
dti-1318	824	10	benleulmi	benleulmi	PROPN
dti-1318	824	11	,	,	PUNCT
dti-1318	824	12	m.s	m.s	PROPN
dti-1318	824	13	.	.	PROPN
dti-1318	824	14	,	,	PUNCT
dti-1318	824	15	porumb	porumb	PROPN
dti-1318	824	16	,	,	PUNCT
dti-1318	824	17	h.	h.	PROPN
dti-1318	824	18	,	,	PUNCT
dti-1318	824	19	zargarian	zargarian	PROPN
dti-1318	824	20	,	,	PUNCT
dti-1318	824	21	l.	l.	PROPN
dti-1318	824	22	,	,	PUNCT
dti-1318	824	23	merad	merad	PROPN
dti-1318	824	24	,	,	PUNCT
dti-1318	824	25	h.	h.	PROPN
dti-1318	824	26	,	,	PUNCT
dti-1318	824	27	leh	leh	PROPN
dti-1318	824	28	,	,	PUNCT
dti-1318	824	29	h.	h.	PROPN
dti-1318	824	30	,	,	PUNCT
dti-1318	824	31	mouscadet	mouscadet	PROPN
dti-1318	824	32	,	,	PUNCT
dti-1318	824	33	j.f	j.f	PROPN
dti-1318	824	34	.	.	PROPN
dti-1318	824	35	,	,	PUNCT
dti-1318	824	36	troalen	troalen	PROPN
dti-1318	824	37	,	,	PUNCT
dti-1318	824	38	f.	f.	PROPN
dti-1318	824	39	and	and	CCONJ
dti-1318	824	40	fermandjian	fermandjian	NOUN
dti-1318	824	41	,	,	PUNCT
dti-1318	824	42	s.	s.	PROPN
dti-1318	824	43	2001	2001	NUM
dti-1318	824	44	.	.	PUNCT
dti-1318	825	1	peptide	peptide	ADJ
dti-1318	825	2	inhibitors	inhibitor	NOUN
dti-1318	825	3	of	of	ADP
dti-1318	825	4	hiv-1	hiv-1	X
dti-1318	825	5	integrase	integrase	NOUN
dti-1318	825	6	dissociate	dissociate	VERB
dti-1318	825	7	the	the	DET
dti-1318	825	8	enzyme	enzyme	NOUN
dti-1318	825	9	oligomers	oligomer	NOUN
dti-1318	825	10	.	.	PUNCT
dti-1318	826	1	biochemistry	biochemistry	NOUN
dti-1318	826	2	,	,	PUNCT
dti-1318	826	3	40:13840–13848	40:13840–13848	NUM
dti-1318	826	4	.	.	PUNCT
dti-1318	827	1	martin	martin	PROPN
dti-1318	827	2	-	-	PUNCT
dti-1318	827	3	serrano	serrano	PROPN
dti-1318	827	4	,	,	PUNCT
dti-1318	827	5	j.	j.	PROPN
dti-1318	827	6	,	,	PUNCT
dti-1318	827	7	zang	zang	PROPN
dti-1318	827	8	,	,	PUNCT
dti-1318	827	9	t.	t.	PROPN
dti-1318	827	10	and	and	CCONJ
dti-1318	827	11	bieniasz	bieniasz	PROPN
dti-1318	827	12	,	,	PUNCT
dti-1318	827	13	p.d	p.d	PROPN
dti-1318	827	14	.	.	PROPN
dti-1318	827	15	2001	2001	NUM
dti-1318	827	16	.	.	PUNCT
dti-1318	827	17	hiv-1	hiv-1	PUNCT
dti-1318	827	18	and	and	CCONJ
dti-1318	827	19	ebola	ebola	PROPN
dti-1318	827	20	virus	virus	NOUN
dti-1318	827	21	encode	encode	ADJ
dti-1318	827	22	small	small	ADJ
dti-1318	827	23	peptide	peptide	NOUN
dti-1318	827	24	motifs	motif	NOUN
dti-1318	827	25	that	that	PRON
dti-1318	827	26	recruit	recruit	VERB
dti-1318	827	27	tsg101	tsg101	PROPN
dti-1318	827	28	to	to	ADP
dti-1318	827	29	sites	site	NOUN
dti-1318	827	30	of	of	ADP
dti-1318	827	31	particle	particle	NOUN
dti-1318	827	32	assembly	assembly	NOUN
dti-1318	827	33	to	to	PART
dti-1318	827	34	facilitate	facilitate	VERB
dti-1318	827	35	egress	egress	NOUN
dti-1318	827	36	.	.	PUNCT
dti-1318	828	1	nat	nat	PROPN
dti-1318	828	2	.	.	PUNCT
dti-1318	829	1	med	med	PROPN
dti-1318	829	2	.	.	PROPN
dti-1318	829	3	,	,	PUNCT
dti-1318	830	1	7:1313–1319	7:1313–1319	PROPN
dti-1318	830	2	.	.	PUNCT
dti-1318	830	3	mcphee	mcphee	PROPN
dti-1318	830	4	,	,	PUNCT
dti-1318	830	5	f.	f.	PROPN
dti-1318	830	6	,	,	PUNCT
dti-1318	830	7	good	good	ADJ
dti-1318	830	8	,	,	PUNCT
dti-1318	830	9	a.c	a.c	PROPN
dti-1318	830	10	.	.	PROPN
dti-1318	830	11	,	,	PUNCT
dti-1318	830	12	kuntz	kuntz	PROPN
dti-1318	830	13	,	,	PUNCT
dti-1318	830	14	i.d	i.d	PROPN
dti-1318	830	15	.	.	PROPN
dti-1318	830	16	and	and	CCONJ
dti-1318	830	17	craik	craik	NOUN
dti-1318	830	18	,	,	PUNCT
dti-1318	830	19	c.s	c.s	PROPN
dti-1318	830	20	.	.	PROPN
dti-1318	830	21	1996	1996	NUM
dti-1318	830	22	.	.	PUNCT
dti-1318	831	1	engineering	engineer	VERB
dti-1318	831	2	human	human	ADJ
dti-1318	831	3	immunodefi	immunodefi	PROPN
dti-1318	831	4	ciency	ciency	NOUN
dti-1318	831	5	virus	virus	NOUN
dti-1318	831	6	1	1	NUM
dti-1318	831	7	protease	protease	NOUN
dti-1318	831	8	heterodimers	heterodimer	NOUN
dti-1318	831	9	as	as	ADP
dti-1318	831	10	macromolecular	macromolecular	ADJ
dti-1318	831	11	inhibitors	inhibitor	NOUN
dti-1318	831	12	of	of	ADP
dti-1318	831	13	viral	viral	ADJ
dti-1318	831	14	maturation	maturation	NOUN
dti-1318	831	15	.	.	PUNCT
dti-1318	832	1	proc	proc	PROPN
dti-1318	832	2	.	.	PUNCT
dti-1318	833	1	natl	natl	PROPN
dti-1318	833	2	.	.	PUNCT
dti-1318	834	1	acad	acad	PROPN
dti-1318	834	2	.	.	PUNCT
dti-1318	835	1	sci	sci	PROPN
dti-1318	835	2	.	.	PUNCT
dti-1318	835	3	u.s.a	u.s.a	PROPN
dti-1318	835	4	.	.	PROPN
dti-1318	835	5	,	,	PUNCT
dti-1318	836	1	93:11477–11481	93:11477–11481	NUM
dti-1318	836	2	.	.	PUNCT
dti-1318	837	1	mehle	mehle	PROPN
dti-1318	837	2	,	,	PUNCT
dti-1318	837	3	a.	a.	NOUN
dti-1318	837	4	,	,	PUNCT
dti-1318	837	5	strack	strack	NOUN
dti-1318	837	6	,	,	PUNCT
dti-1318	837	7	b.	b.	PROPN
dti-1318	837	8	,	,	PUNCT
dti-1318	837	9	ancuta	ancuta	ADV
dti-1318	837	10	,	,	PUNCT
dti-1318	837	11	p.	p.	PROPN
dti-1318	837	12	,	,	PUNCT
dti-1318	837	13	zhang	zhang	PROPN
dti-1318	837	14	,	,	PUNCT
dti-1318	837	15	c.	c.	PROPN
dti-1318	837	16	,	,	PUNCT
dti-1318	837	17	mcpike	mcpike	PROPN
dti-1318	837	18	,	,	PUNCT
dti-1318	837	19	m.	m.	NOUN
dti-1318	837	20	and	and	CCONJ
dti-1318	837	21	gabuzda	gabuzda	NOUN
dti-1318	837	22	,	,	PUNCT
dti-1318	837	23	d.	d.	PROPN
dti-1318	837	24	2004	2004	NUM
dti-1318	837	25	.	.	PUNCT
dti-1318	838	1	vif	vif	NOUN
dti-1318	838	2	overcomes	overcome	VERB
dti-1318	838	3	the	the	DET
dti-1318	838	4	innate	innate	ADJ
dti-1318	838	5	antiviral	antiviral	ADJ
dti-1318	838	6	activity	activity	NOUN
dti-1318	838	7	of	of	ADP
dti-1318	838	8	apobec3	apobec3	PROPN
dti-1318	838	9	g	g	NOUN
dti-1318	838	10	by	by	ADP
dti-1318	838	11	promoting	promote	VERB
dti-1318	838	12	its	its	PRON
dti-1318	838	13	degradation	degradation	NOUN
dti-1318	838	14	in	in	ADP
dti-1318	838	15	the	the	DET
dti-1318	838	16	ubiquitin	ubiquitin	ADJ
dti-1318	838	17	-	-	PUNCT
dti-1318	838	18	proteasome	proteasome	NOUN
dti-1318	838	19	pathway	pathway	NOUN
dti-1318	838	20	.	.	PUNCT
dti-1318	839	1	j.	j.	PROPN
dti-1318	839	2	biol	biol	PROPN
dti-1318	839	3	.	.	PUNCT
dti-1318	840	1	chem	chem	PROPN
dti-1318	840	2	.	.	PUNCT
dti-1318	840	3	,	,	PUNCT
dti-1318	841	1	279:7792–7798	279:7792–7798	X
dti-1318	841	2	.	.	PUNCT
dti-1318	842	1	meng	meng	PROPN
dti-1318	842	2	,	,	PUNCT
dti-1318	842	3	l.	l.	PROPN
dti-1318	842	4	,	,	PUNCT
dti-1318	842	5	mohan	mohan	PROPN
dti-1318	842	6	,	,	PUNCT
dti-1318	842	7	r.	r.	PROPN
dti-1318	842	8	,	,	PUNCT
dti-1318	842	9	kwok	kwok	PROPN
dti-1318	842	10	,	,	PUNCT
dti-1318	842	11	b.h	b.h	PROPN
dti-1318	842	12	.	.	PROPN
dti-1318	842	13	,	,	PUNCT
dti-1318	842	14	elofsson	elofsson	PROPN
dti-1318	842	15	,	,	PUNCT
dti-1318	842	16	m.	m.	NOUN
dti-1318	842	17	,	,	PUNCT
dti-1318	842	18	sin	sin	NOUN
dti-1318	842	19	,	,	PUNCT
dti-1318	842	20	n.	n.	NOUN
dti-1318	842	21	and	and	CCONJ
dti-1318	842	22	crews	crew	NOUN
dti-1318	842	23	,	,	PUNCT
dti-1318	842	24	c.m	c.m	PROPN
dti-1318	842	25	.	.	PROPN
dti-1318	842	26	1999	1999	NUM
dti-1318	842	27	.	.	PUNCT
dti-1318	843	1	epoxomicin	epoxomicin	PROPN
dti-1318	843	2	,	,	PUNCT
dti-1318	843	3	a	a	DET
dti-1318	843	4	potent	potent	ADJ
dti-1318	843	5	and	and	CCONJ
dti-1318	843	6	selective	selective	ADJ
dti-1318	843	7	proteasome	proteasome	NOUN
dti-1318	843	8	inhibitor	inhibitor	NOUN
dti-1318	843	9	,	,	PUNCT
dti-1318	843	10	exhibits	exhibit	VERB
dti-1318	843	11	in	in	ADP
dti-1318	843	12	vivo	vivo	ADJ
dti-1318	843	13	antiinfl	antiinfl	NOUN
dti-1318	843	14	ammatory	ammatory	NOUN
dti-1318	843	15	activity	activity	NOUN
dti-1318	843	16	.	.	PUNCT
dti-1318	844	1	proc	proc	PROPN
dti-1318	844	2	.	.	PUNCT
dti-1318	845	1	natl	natl	PROPN
dti-1318	845	2	.	.	PUNCT
dti-1318	846	1	acad	acad	PROPN
dti-1318	846	2	.	.	PUNCT
dti-1318	847	1	sci	sci	PROPN
dti-1318	847	2	.	.	PUNCT
dti-1318	847	3	u.s.a	u.s.a	PROPN
dti-1318	847	4	.	.	PROPN
dti-1318	847	5	,	,	PUNCT
dti-1318	847	6	96:10403–10408	96:10403–10408	X
dti-1318	847	7	.	.	PUNCT
dti-1318	848	1	merabet	merabet	PROPN
dti-1318	848	2	,	,	PUNCT
dti-1318	848	3	n.	n.	NOUN
dti-1318	848	4	,	,	PUNCT
dti-1318	848	5	dumond	dumond	PROPN
dti-1318	848	6	,	,	PUNCT
dti-1318	848	7	j.	j.	PROPN
dti-1318	848	8	,	,	PUNCT
dti-1318	848	9	collinet	collinet	PROPN
dti-1318	848	10	,	,	PUNCT
dti-1318	848	11	b.	b.	PROPN
dti-1318	848	12	,	,	PUNCT
dti-1318	848	13	van	van	PROPN
dti-1318	848	14	baelinghem	baelinghem	PROPN
dti-1318	848	15	,	,	PUNCT
dti-1318	848	16	l.	l.	PROPN
dti-1318	848	17	,	,	PUNCT
dti-1318	848	18	boggetto	boggetto	PROPN
dti-1318	848	19	,	,	PUNCT
dti-1318	848	20	n.	n.	NOUN
dti-1318	848	21	,	,	PUNCT
dti-1318	848	22	ongeri	ongeri	NOUN
dti-1318	848	23	,	,	PUNCT
dti-1318	848	24	s.	s.	PROPN
dti-1318	848	25	,	,	PUNCT
dti-1318	848	26	ressad	ressad	PROPN
dti-1318	848	27	,	,	PUNCT
dti-1318	848	28	f.	f.	PROPN
dti-1318	848	29	,	,	PUNCT
dti-1318	848	30	reboud	reboud	PROPN
dti-1318	848	31	-	-	PUNCT
dti-1318	848	32	ravaux	ravaux	NOUN
dti-1318	848	33	,	,	PUNCT
dti-1318	848	34	m.	m.	NOUN
dti-1318	848	35	and	and	CCONJ
dti-1318	848	36	sicsic	sicsic	ADJ
dti-1318	848	37	,	,	PUNCT
dti-1318	848	38	s.	s.	PROPN
dti-1318	848	39	2004	2004	NUM
dti-1318	848	40	.	.	PUNCT
dti-1318	849	1	new	new	ADJ
dti-1318	849	2	constrained	constrain	VERB
dti-1318	849	3	“	"	PUNCT
dti-1318	849	4	molecular	molecular	ADJ
dti-1318	849	5	tongs	tong	NOUN
dti-1318	849	6	”	"	PUNCT
dti-1318	849	7	designed	design	VERB
dti-1318	849	8	to	to	PART
dti-1318	849	9	dissociate	dissociate	VERB
dti-1318	849	10	hiv-1	hiv-1	X
dti-1318	849	11	protease	protease	NOUN
dti-1318	849	12	dimer	dimer	NOUN
dti-1318	849	13	.	.	PUNCT
dti-1318	850	1	j.	j.	PROPN
dti-1318	850	2	med	med	PROPN
dti-1318	850	3	.	.	PROPN
dti-1318	850	4	chem	chem	PROPN
dti-1318	850	5	.	.	PUNCT
dti-1318	850	6	,	,	PUNCT
dti-1318	850	7	47:6392–6400	47:6392–6400	NUM
dti-1318	850	8	.	.	PUNCT
dti-1318	851	1	momany	momany	PROPN
dti-1318	851	2	,	,	PUNCT
dti-1318	851	3	c.	c.	PROPN
dti-1318	851	4	,	,	PUNCT
dti-1318	851	5	kovari	kovari	PROPN
dti-1318	851	6	,	,	PUNCT
dti-1318	851	7	l.c	l.c	PROPN
dti-1318	851	8	.	.	PROPN
dti-1318	851	9	,	,	PUNCT
dti-1318	851	10	prongay	prongay	PROPN
dti-1318	851	11	,	,	PUNCT
dti-1318	851	12	a.j	a.j	PROPN
dti-1318	851	13	.	.	PROPN
dti-1318	851	14	,	,	PUNCT
dti-1318	851	15	keller	keller	PROPN
dti-1318	851	16	,	,	PUNCT
dti-1318	851	17	w.	w.	PROPN
dti-1318	851	18	,	,	PUNCT
dti-1318	851	19	gitti	gitti	PROPN
dti-1318	851	20	,	,	PUNCT
dti-1318	851	21	r.k	r.k	PROPN
dti-1318	851	22	.	.	PROPN
dti-1318	851	23	,	,	PUNCT
dti-1318	851	24	lee	lee	PROPN
dti-1318	851	25	,	,	PUNCT
dti-1318	851	26	b.m	b.m	PROPN
dti-1318	851	27	.	.	PROPN
dti-1318	851	28	,	,	PUNCT
dti-1318	851	29	gorbalenya	gorbalenya	PROPN
dti-1318	851	30	,	,	PUNCT
dti-1318	851	31	a.e	a.e	PROPN
dti-1318	851	32	.	.	PROPN
dti-1318	851	33	,	,	PUNCT
dti-1318	851	34	tong	tong	PROPN
dti-1318	851	35	,	,	PUNCT
dti-1318	851	36	l.	l.	PROPN
dti-1318	851	37	,	,	PUNCT
dti-1318	851	38	mcclure	mcclure	PROPN
dti-1318	851	39	,	,	PUNCT
dti-1318	851	40	j.	j.	PROPN
dti-1318	851	41	,	,	PUNCT
dti-1318	851	42	ehrlich	ehrlich	PROPN
dti-1318	851	43	,	,	PUNCT
dti-1318	851	44	l.s	l.s	PROPN
dti-1318	851	45	.	.	PROPN
dti-1318	851	46	,	,	PUNCT
dti-1318	851	47	summers	summer	NOUN
dti-1318	851	48	,	,	PUNCT
dti-1318	851	49	m.f	m.f	PROPN
dti-1318	851	50	.	.	PROPN
dti-1318	851	51	,	,	PUNCT
dti-1318	851	52	carter	carter	PROPN
dti-1318	851	53	,	,	PUNCT
dti-1318	851	54	c.	c.	PROPN
dti-1318	851	55	and	and	CCONJ
dti-1318	851	56	rossmann	rossmann	PROPN
dti-1318	851	57	,	,	PUNCT
dti-1318	851	58	m.g	m.g	PROPN
dti-1318	851	59	.	.	PROPN
dti-1318	851	60	1996	1996	NUM
dti-1318	851	61	.	.	PUNCT
dti-1318	852	1	crystal	crystal	NOUN
dti-1318	852	2	structure	structure	NOUN
dti-1318	852	3	of	of	ADP
dti-1318	852	4	dimeric	dimeric	ADJ
dti-1318	852	5	hiv-1	hiv-1	PUNCT
dti-1318	852	6	capsid	capsid	ADJ
dti-1318	852	7	protein	protein	NOUN
dti-1318	852	8	.	.	PUNCT
dti-1318	853	1	nat	nat	PROPN
dti-1318	853	2	.	.	PUNCT
dti-1318	853	3	struct	struct	NOUN
dti-1318	853	4	.	.	PUNCT
dti-1318	854	1	biol	biol	PROPN
dti-1318	854	2	.	.	PUNCT
dti-1318	854	3	,	,	PUNCT
dti-1318	854	4	3:763–770	3:763–770	PROPN
dti-1318	854	5	.	.	PUNCT
dti-1318	855	1	morikawa	morikawa	NOUN
dti-1318	855	2	,	,	PUNCT
dti-1318	855	3	y.	y.	PROPN
dti-1318	855	4	,	,	PUNCT
dti-1318	855	5	hinata	hinata	PROPN
dti-1318	855	6	,	,	PUNCT
dti-1318	855	7	s.	s.	PROPN
dti-1318	855	8	,	,	PUNCT
dti-1318	855	9	tomoda	tomoda	PROPN
dti-1318	855	10	,	,	PUNCT
dti-1318	855	11	h.	h.	PROPN
dti-1318	855	12	,	,	PUNCT
dti-1318	855	13	goto	goto	NOUN
dti-1318	855	14	,	,	PUNCT
dti-1318	855	15	t.	t.	PROPN
dti-1318	855	16	,	,	PUNCT
dti-1318	855	17	nakai	nakai	PROPN
dti-1318	855	18	,	,	PUNCT
dti-1318	855	19	m.	m.	NOUN
dti-1318	855	20	,	,	PUNCT
dti-1318	855	21	aizawa	aizawa	PROPN
dti-1318	855	22	,	,	PUNCT
dti-1318	855	23	c.	c.	PROPN
dti-1318	855	24	,	,	PUNCT
dti-1318	855	25	tanaka	tanaka	PROPN
dti-1318	855	26	,	,	PUNCT
dti-1318	855	27	h.	h.	PROPN
dti-1318	855	28	and	and	CCONJ
dti-1318	855	29	omura	omura	PROPN
dti-1318	855	30	,	,	PUNCT
dti-1318	855	31	s.	s.	PROPN
dti-1318	855	32	1996	1996	NUM
dti-1318	855	33	.	.	PUNCT
dti-1318	856	1	complete	complete	ADJ
dti-1318	856	2	inhibition	inhibition	NOUN
dti-1318	856	3	of	of	ADP
dti-1318	856	4	human	human	ADJ
dti-1318	856	5	immunodefi	immunodefi	PROPN
dti-1318	856	6	ciency	ciency	NOUN
dti-1318	856	7	virus	virus	NOUN
dti-1318	856	8	gag	gag	NOUN
dti-1318	856	9	myristoylation	myristoylation	NOUN
dti-1318	856	10	is	be	AUX
dti-1318	856	11	necessary	necessary	ADJ
dti-1318	856	12	for	for	ADP
dti-1318	856	13	inhibition	inhibition	NOUN
dti-1318	856	14	of	of	ADP
dti-1318	856	15	particle	particle	NOUN
dti-1318	856	16	budding	budding	NOUN
dti-1318	856	17	.	.	PUNCT
dti-1318	857	1	j.	j.	PROPN
dti-1318	857	2	biol	biol	PROPN
dti-1318	857	3	.	.	PUNCT
dti-1318	858	1	chem	chem	PROPN
dti-1318	858	2	.	.	PUNCT
dti-1318	858	3	,	,	PUNCT
dti-1318	858	4	271:2868–2873	271:2868–2873	PROPN
dti-1318	858	5	.	.	PUNCT
dti-1318	859	1	morris	morris	PROPN
dti-1318	859	2	,	,	PUNCT
dti-1318	859	3	m.c	m.c	PROPN
dti-1318	859	4	.	.	PROPN
dti-1318	859	5	,	,	PUNCT
dti-1318	859	6	berducou	berducou	NOUN
dti-1318	859	7	,	,	PUNCT
dti-1318	859	8	c.	c.	PROPN
dti-1318	859	9	,	,	PUNCT
dti-1318	859	10	mery	mery	PROPN
dti-1318	859	11	,	,	PUNCT
dti-1318	859	12	j.	j.	PROPN
dti-1318	859	13	,	,	PUNCT
dti-1318	859	14	heitz	heitz	PROPN
dti-1318	859	15	,	,	PUNCT
dti-1318	859	16	f.	f.	PROPN
dti-1318	859	17	and	and	CCONJ
dti-1318	859	18	divita	divita	PROPN
dti-1318	859	19	,	,	PUNCT
dti-1318	859	20	g.	g.	PROPN
dti-1318	859	21	1999a	1999a	NUM
dti-1318	859	22	.	.	PUNCT
dti-1318	860	1	the	the	DET
dti-1318	860	2	thumb	thumb	NOUN
dti-1318	860	3	domain	domain	NOUN
dti-1318	860	4	of	of	ADP
dti-1318	860	5	the	the	DET
dti-1318	860	6	p51	p51	NOUN
dti-1318	860	7	-	-	PUNCT
dti-1318	860	8	subunit	subunit	NOUN
dti-1318	860	9	is	be	AUX
dti-1318	860	10	essential	essential	ADJ
dti-1318	860	11	for	for	ADP
dti-1318	860	12	activation	activation	NOUN
dti-1318	860	13	of	of	ADP
dti-1318	860	14	hiv	hiv	PROPN
dti-1318	860	15	reverse	reverse	NOUN
dti-1318	860	16	transcriptase	transcriptase	VERB
dti-1318	860	17	.	.	PUNCT
dti-1318	861	1	biochemistry	biochemistry	NOUN
dti-1318	861	2	,	,	PUNCT
dti-1318	861	3	38:15097–15103	38:15097–15103	X
dti-1318	861	4	.	.	PUNCT
dti-1318	861	5	morris	morris	PROPN
dti-1318	861	6	,	,	PUNCT
dti-1318	861	7	m.c	m.c	PROPN
dti-1318	861	8	.	.	PROPN
dti-1318	861	9	,	,	PUNCT
dti-1318	861	10	robert	robert	PROPN
dti-1318	861	11	-	-	PUNCT
dti-1318	861	12	hebmann	hebmann	PROPN
dti-1318	861	13	,	,	PUNCT
dti-1318	861	14	v.	v.	PROPN
dti-1318	861	15	,	,	PUNCT
dti-1318	861	16	chaloin	chaloin	PROPN
dti-1318	861	17	,	,	PUNCT
dti-1318	861	18	l.	l.	PROPN
dti-1318	861	19	,	,	PUNCT
dti-1318	861	20	mery	mery	PROPN
dti-1318	861	21	,	,	PUNCT
dti-1318	861	22	j.	j.	PROPN
dti-1318	861	23	,	,	PUNCT
dti-1318	861	24	heitz	heitz	PROPN
dti-1318	861	25	,	,	PUNCT
dti-1318	861	26	f.	f.	PROPN
dti-1318	861	27	,	,	PUNCT
dti-1318	861	28	devaux	devaux	PROPN
dti-1318	861	29	,	,	PUNCT
dti-1318	861	30	c.	c.	NOUN
dti-1318	861	31	,	,	PUNCT
dti-1318	861	32	goody	goody	NOUN
dti-1318	861	33	,	,	PUNCT
dti-1318	861	34	r.s	r.s	PROPN
dti-1318	861	35	.	.	PROPN
dti-1318	861	36	and	and	CCONJ
dti-1318	861	37	divita	divita	PROPN
dti-1318	861	38	,	,	PUNCT
dti-1318	861	39	g.	g.	PROPN
dti-1318	861	40	1999b	1999b	NUM
dti-1318	861	41	.	.	PUNCT
dti-1318	862	1	a	a	DET
dti-1318	862	2	new	new	ADJ
dti-1318	862	3	potent	potent	NOUN
dti-1318	862	4	hiv-1	hiv-1	X
dti-1318	862	5	reverse	reverse	ADJ
dti-1318	862	6	transcriptase	transcriptase	NOUN
dti-1318	862	7	inhibitor	inhibitor	NOUN
dti-1318	862	8	.	.	PUNCT
dti-1318	863	1	a	a	DET
dti-1318	863	2	synthetic	synthetic	ADJ
dti-1318	863	3	peptide	peptide	NOUN
dti-1318	863	4	derived	derive	VERB
dti-1318	863	5	from	from	ADP
dti-1318	863	6	the	the	DET
dti-1318	863	7	interface	interface	NOUN
dti-1318	863	8	subunit	subunit	NOUN
dti-1318	863	9	domains	domain	NOUN
dti-1318	863	10	.	.	PUNCT
dti-1318	864	1	j.	j.	PROPN
dti-1318	864	2	biol	biol	PROPN
dti-1318	864	3	.	.	PUNCT
dti-1318	865	1	chem	chem	PROPN
dti-1318	865	2	.	.	PUNCT
dti-1318	865	3	,	,	PUNCT
dti-1318	866	1	274:24941–24946	274:24941–24946	NUM
dti-1318	866	2	.	.	PUNCT
dti-1318	867	1	muriaux	muriaux	PROPN
dti-1318	867	2	,	,	PUNCT
dti-1318	867	3	d.	d.	PROPN
dti-1318	867	4	,	,	PUNCT
dti-1318	867	5	darlix	darlix	ADJ
dti-1318	867	6	,	,	PUNCT
dti-1318	867	7	j.l	j.l	PROPN
dti-1318	867	8	.	.	PROPN
dti-1318	867	9	and	and	CCONJ
dti-1318	867	10	cimarelli	cimarelli	PROPN
dti-1318	867	11	,	,	PUNCT
dti-1318	867	12	a.	a.	NOUN
dti-1318	867	13	2004	2004	NUM
dti-1318	867	14	.	.	PUNCT
dti-1318	868	1	targeting	target	VERB
dti-1318	868	2	the	the	DET
dti-1318	868	3	assembly	assembly	NOUN
dti-1318	868	4	of	of	ADP
dti-1318	868	5	the	the	DET
dti-1318	868	6	human	human	ADJ
dti-1318	868	7	immunodefi	immunodefi	PROPN
dti-1318	868	8	ciency	ciency	NOUN
dti-1318	868	9	virus	virus	NOUN
dti-1318	868	10	type	type	NOUN
dti-1318	868	11	i.	i.	PROPN
dti-1318	868	12	curr	curr	PROPN
dti-1318	868	13	.	.	PUNCT
dti-1318	869	1	pharm	pharm	PROPN
dti-1318	869	2	.	.	PUNCT
dti-1318	870	1	des	des	PROPN
dti-1318	870	2	.	.	PROPN
dti-1318	870	3	,	,	PUNCT
dti-1318	870	4	10:3725–3739	10:3725–3739	PROPN
dti-1318	870	5	.	.	PUNCT
dti-1318	871	1	neil	neil	PROPN
dti-1318	871	2	,	,	PUNCT
dti-1318	871	3	s.j	s.j	PROPN
dti-1318	871	4	.	.	PROPN
dti-1318	871	5	,	,	PUNCT
dti-1318	871	6	eastman	eastman	PROPN
dti-1318	871	7	,	,	PUNCT
dti-1318	871	8	s.w	s.w	PROPN
dti-1318	871	9	.	.	PROPN
dti-1318	871	10	,	,	PUNCT
dti-1318	871	11	jouvenet	jouvenet	NOUN
dti-1318	871	12	,	,	PUNCT
dti-1318	871	13	n.	n.	NOUN
dti-1318	871	14	and	and	CCONJ
dti-1318	871	15	bieniasz	bieniasz	PROPN
dti-1318	871	16	,	,	PUNCT
dti-1318	871	17	p.d	p.d	PROPN
dti-1318	871	18	.	.	PROPN
dti-1318	871	19	2006	2006	NUM
dti-1318	871	20	.	.	PUNCT
dti-1318	871	21	hiv-1	hiv-1	X
dti-1318	871	22	vpu	vpu	NOUN
dti-1318	871	23	promotes	promote	VERB
dti-1318	871	24	release	release	NOUN
dti-1318	871	25	and	and	CCONJ
dti-1318	871	26	prevents	prevent	VERB
dti-1318	871	27	endocytosis	endocytosis	NOUN
dti-1318	871	28	of	of	ADP
dti-1318	871	29	nascent	nascent	ADJ
dti-1318	871	30	retrovirus	retrovirus	NOUN
dti-1318	871	31	particles	particle	NOUN
dti-1318	871	32	from	from	ADP
dti-1318	871	33	the	the	DET
dti-1318	871	34	plasma	plasma	NOUN
dti-1318	871	35	membrane	membrane	NOUN
dti-1318	871	36	.	.	PUNCT
dti-1318	872	1	plos	plos	PROPN
dti-1318	872	2	pathog	pathog	PROPN
dti-1318	872	3	.	.	PUNCT
dti-1318	872	4	,	,	PUNCT
dti-1318	872	5	2	2	NUM
dti-1318	872	6	:	:	SYM
dti-1318	872	7	e39	e39	NOUN
dti-1318	872	8	.	.	PUNCT
dti-1318	873	1	nguyen	nguyen	PROPN
dti-1318	873	2	,	,	PUNCT
dti-1318	873	3	j.t	j.t	PROPN
dti-1318	873	4	.	.	PROPN
dti-1318	873	5	,	,	PUNCT
dti-1318	873	6	porter	porter	NOUN
dti-1318	873	7	,	,	PUNCT
dti-1318	873	8	m.	m.	NOUN
dti-1318	873	9	,	,	PUNCT
dti-1318	873	10	amoui	amoui	PROPN
dti-1318	873	11	,	,	PUNCT
dti-1318	873	12	m.	m.	NOUN
dti-1318	873	13	,	,	PUNCT
dti-1318	873	14	miller	miller	PROPN
dti-1318	873	15	,	,	PUNCT
dti-1318	873	16	w.t	w.t	PROPN
dti-1318	873	17	.	.	PROPN
dti-1318	873	18	,	,	PUNCT
dti-1318	873	19	zuckermann	zuckermann	PROPN
dti-1318	873	20	,	,	PUNCT
dti-1318	873	21	r.n	r.n	PROPN
dti-1318	873	22	.	.	PROPN
dti-1318	873	23	and	and	CCONJ
dti-1318	873	24	lim	lim	PROPN
dti-1318	873	25	,	,	PUNCT
dti-1318	873	26	w.a	w.a	PROPN
dti-1318	873	27	.	.	PROPN
dti-1318	873	28	2000	2000	NUM
dti-1318	873	29	.	.	PUNCT
dti-1318	874	1	improving	improve	VERB
dti-1318	874	2	sh3	sh3	NOUN
dti-1318	874	3	domain	domain	NOUN
dti-1318	874	4	ligand	ligand	NOUN
dti-1318	874	5	selectivity	selectivity	NOUN
dti-1318	874	6	using	use	VERB
dti-1318	874	7	a	a	DET
dti-1318	874	8	non	non	ADJ
dti-1318	874	9	-	-	ADJ
dti-1318	874	10	natural	natural	ADJ
dti-1318	874	11	scaffold	scaffold	NOUN
dti-1318	874	12	.	.	PUNCT
dti-1318	875	1	chem	chem	NOUN
dti-1318	875	2	.	.	PUNCT
dti-1318	876	1	biol	biol	PROPN
dti-1318	876	2	.	.	PUNCT
dti-1318	876	3	,	,	PUNCT
dti-1318	876	4	7:463–473	7:463–473	NOUN
dti-1318	876	5	.	.	PUNCT
dti-1318	877	1	niedrig	niedrig	PROPN
dti-1318	877	2	,	,	PUNCT
dti-1318	877	3	m.	m.	NOUN
dti-1318	877	4	,	,	PUNCT
dti-1318	877	5	gelderblom	gelderblom	NOUN
dti-1318	877	6	,	,	PUNCT
dti-1318	877	7	h.r	h.r	PROPN
dti-1318	877	8	.	.	PROPN
dti-1318	877	9	,	,	PUNCT
dti-1318	877	10	pauli	pauli	PROPN
dti-1318	877	11	,	,	PUNCT
dti-1318	877	12	g.	g.	PROPN
dti-1318	877	13	,	,	PUNCT
dti-1318	877	14	marz	marz	PROPN
dti-1318	877	15	,	,	PUNCT
dti-1318	877	16	j.	j.	PROPN
dti-1318	877	17	,	,	PUNCT
dti-1318	877	18	bickhard	bickhard	PROPN
dti-1318	877	19	,	,	PUNCT
dti-1318	877	20	h.	h.	PROPN
dti-1318	877	21	,	,	PUNCT
dti-1318	877	22	wolf	wolf	PROPN
dti-1318	877	23	,	,	PUNCT
dti-1318	877	24	h.	h.	PROPN
dti-1318	877	25	and	and	CCONJ
dti-1318	877	26	modrow	modrow	PROPN
dti-1318	877	27	,	,	PUNCT
dti-1318	877	28	s.	s.	PROPN
dti-1318	877	29	1994	1994	NUM
dti-1318	877	30	.	.	PUNCT
dti-1318	878	1	inhibition	inhibition	NOUN
dti-1318	878	2	of	of	ADP
dti-1318	878	3	infectious	infectious	ADJ
dti-1318	878	4	human	human	ADJ
dti-1318	878	5	immunodefi	immunodefi	NOUN
dti-1318	878	6	ciency	ciency	NOUN
dti-1318	878	7	virus	virus	NOUN
dti-1318	878	8	type	type	NOUN
dti-1318	878	9	1	1	NUM
dti-1318	878	10	particle	particle	NOUN
dti-1318	878	11	formation	formation	NOUN
dti-1318	878	12	by	by	ADP
dti-1318	878	13	gag	gag	NOUN
dti-1318	878	14	protein	protein	NOUN
dti-1318	878	15	-	-	PUNCT
dti-1318	878	16	derived	derive	VERB
dti-1318	878	17	peptides	peptide	NOUN
dti-1318	878	18	.	.	PUNCT
dti-1318	879	1	j.	j.	PROPN
dti-1318	879	2	gen	gen	PROPN
dti-1318	879	3	.	.	PROPN
dti-1318	879	4	virol	virol	PROPN
dti-1318	879	5	.	.	PUNCT
dti-1318	879	6	,	,	PUNCT
dti-1318	879	7	75:1469–1474	75:1469–1474	PROPN
dti-1318	879	8	.	.	PUNCT
dti-1318	879	9	ono	ono	PROPN
dti-1318	879	10	,	,	PUNCT
dti-1318	879	11	a.	a.	PROPN
dti-1318	879	12	,	,	PUNCT
dti-1318	879	13	ablan	ablan	PROPN
dti-1318	879	14	,	,	PUNCT
dti-1318	879	15	s.d	s.d	PROPN
dti-1318	879	16	.	.	PROPN
dti-1318	879	17	,	,	PUNCT
dti-1318	879	18	lockett	lockett	PROPN
dti-1318	879	19	,	,	PUNCT
dti-1318	879	20	s.j	s.j	PROPN
dti-1318	879	21	.	.	PROPN
dti-1318	879	22	,	,	PUNCT
dti-1318	879	23	nagashima	nagashima	PROPN
dti-1318	879	24	,	,	PUNCT
dti-1318	879	25	k.	k.	PROPN
dti-1318	879	26	and	and	CCONJ
dti-1318	879	27	freed	free	VERB
dti-1318	879	28	,	,	PUNCT
dti-1318	879	29	e.o	e.o	PROPN
dti-1318	879	30	.	.	PROPN
dti-1318	879	31	2004	2004	NUM
dti-1318	879	32	.	.	PUNCT
dti-1318	880	1	phosphatidylinositol	phosphatidylinositol	NOUN
dti-1318	880	2	(	(	PUNCT
dti-1318	880	3	4,5	4,5	NUM
dti-1318	880	4	)	)	PUNCT
dti-1318	880	5	bisphosphate	bisphosphate	NOUN
dti-1318	880	6	regulates	regulate	VERB
dti-1318	880	7	hiv-1	hiv-1	VERB
dti-1318	880	8	gag	gag	NOUN
dti-1318	880	9	targeting	target	VERB
dti-1318	880	10	to	to	ADP
dti-1318	880	11	the	the	DET
dti-1318	880	12	plasma	plasma	NOUN
dti-1318	880	13	membrane	membrane	NOUN
dti-1318	880	14	.	.	PUNCT
dti-1318	881	1	proc	proc	NOUN
dti-1318	881	2	.	.	PUNCT
dti-1318	882	1	natl	natl	PROPN
dti-1318	882	2	.	.	PUNCT
dti-1318	883	1	acad	acad	PROPN
dti-1318	883	2	.	.	PUNCT
dti-1318	884	1	sci	sci	PROPN
dti-1318	884	2	.	.	PUNCT
dti-1318	884	3	u.s.a	u.s.a	PROPN
dti-1318	884	4	.	.	PROPN
dti-1318	884	5	,	,	PUNCT
dti-1318	884	6	101:14889–14894	101:14889–14894	PROPN
dti-1318	884	7	.	.	PROPN
dti-1318	884	8	ono	ono	PROPN
dti-1318	884	9	,	,	PUNCT
dti-1318	884	10	a.	a.	NOUN
dti-1318	884	11	and	and	CCONJ
dti-1318	884	12	freed	free	VERB
dti-1318	884	13	,	,	PUNCT
dti-1318	884	14	e.o	e.o	PROPN
dti-1318	884	15	.	.	PROPN
dti-1318	884	16	1999	1999	NUM
dti-1318	884	17	.	.	PUNCT
dti-1318	885	1	binding	bind	VERB
dti-1318	885	2	of	of	ADP
dti-1318	885	3	human	human	ADJ
dti-1318	885	4	immunodefi	immunodefi	PROPN
dti-1318	885	5	ciency	ciency	NOUN
dti-1318	885	6	virus	virus	NOUN
dti-1318	885	7	type	type	NOUN
dti-1318	885	8	1	1	NUM
dti-1318	885	9	gag	gag	NOUN
dti-1318	885	10	to	to	ADP
dti-1318	885	11	membrane	membrane	NOUN
dti-1318	885	12	:	:	PUNCT
dti-1318	885	13	role	role	NOUN
dti-1318	885	14	of	of	ADP
dti-1318	885	15	the	the	DET
dti-1318	885	16	matrix	matrix	NOUN
dti-1318	885	17	amino	amino	NOUN
dti-1318	885	18	terminus	terminus	NOUN
dti-1318	885	19	.	.	PUNCT
dti-1318	886	1	j.	j.	PROPN
dti-1318	886	2	virol	virol	PROPN
dti-1318	886	3	.	.	PUNCT
dti-1318	886	4	,	,	PUNCT
dti-1318	887	1	73:4136–4144	73:4136–4144	X
dti-1318	887	2	.	.	PUNCT
dti-1318	887	3	ono	ono	PROPN
dti-1318	887	4	,	,	PUNCT
dti-1318	887	5	a.	a.	PROPN
dti-1318	887	6	,	,	PUNCT
dti-1318	887	7	orenstein	orenstein	PROPN
dti-1318	887	8	,	,	PUNCT
dti-1318	887	9	j.m	j.m	PROPN
dti-1318	887	10	.	.	PROPN
dti-1318	887	11	and	and	CCONJ
dti-1318	887	12	freed	free	VERB
dti-1318	887	13	,	,	PUNCT
dti-1318	887	14	e.o	e.o	PROPN
dti-1318	887	15	.	.	PROPN
dti-1318	887	16	2000	2000	NUM
dti-1318	887	17	.	.	PUNCT
dti-1318	888	1	role	role	NOUN
dti-1318	888	2	of	of	ADP
dti-1318	888	3	the	the	DET
dti-1318	888	4	gag	gag	NOUN
dti-1318	888	5	matrix	matrix	NOUN
dti-1318	888	6	domain	domain	NOUN
dti-1318	888	7	in	in	ADP
dti-1318	888	8	targeting	target	VERB
dti-1318	888	9	human	human	ADJ
dti-1318	888	10	immunodefi	immunodefi	PROPN
dti-1318	888	11	ciency	ciency	NOUN
dti-1318	888	12	virus	virus	NOUN
dti-1318	888	13	type	type	NOUN
dti-1318	888	14	1	1	NUM
dti-1318	888	15	assembly	assembly	NOUN
dti-1318	888	16	.	.	PUNCT
dti-1318	889	1	j.	j.	PROPN
dti-1318	889	2	virol	virol	PROPN
dti-1318	889	3	.	.	PUNCT
dti-1318	889	4	,	,	PUNCT
dti-1318	889	5	74:2855–2866	74:2855–2866	PROPN
dti-1318	889	6	.	.	PUNCT
dti-1318	889	7	ott	ott	PROPN
dti-1318	889	8	,	,	PUNCT
dti-1318	889	9	d.e	d.e	PROPN
dti-1318	889	10	.	.	PROPN
dti-1318	889	11	,	,	PUNCT
dti-1318	889	12	coren	coren	PROPN
dti-1318	889	13	,	,	PUNCT
dti-1318	889	14	l.v	l.v	PROPN
dti-1318	889	15	.	.	PROPN
dti-1318	889	16	,	,	PUNCT
dti-1318	889	17	sowder	sowder	NOUN
dti-1318	889	18	,	,	PUNCT
dti-1318	889	19	r.c	r.c	PROPN
dti-1318	889	20	.	.	PROPN
dti-1318	889	21	,	,	PUNCT
dti-1318	889	22	adams	adams	PROPN
dti-1318	889	23	,	,	PUNCT
dti-1318	889	24	j.	j.	PROPN
dti-1318	889	25	and	and	CCONJ
dti-1318	889	26	schubert	schubert	PROPN
dti-1318	889	27	,	,	PUNCT
dti-1318	889	28	u.	u.	PROPN
dti-1318	889	29	2003	2003	NUM
dti-1318	889	30	.	.	PUNCT
dti-1318	890	1	retroviruses	retrovirus	NOUN
dti-1318	890	2	have	have	VERB
dti-1318	890	3	differing	differ	VERB
dti-1318	890	4	requirements	requirement	NOUN
dti-1318	890	5	for	for	ADP
dti-1318	890	6	proteasome	proteasome	NOUN
dti-1318	890	7	function	function	NOUN
dti-1318	890	8	in	in	ADP
dti-1318	890	9	the	the	DET
dti-1318	890	10	budding	bud	VERB
dti-1318	890	11	process	process	NOUN
dti-1318	890	12	.	.	PUNCT
dti-1318	891	1	j.	j.	PROPN
dti-1318	891	2	virol	virol	PROPN
dti-1318	891	3	.	.	PUNCT
dti-1318	891	4	,	,	PUNCT
dti-1318	891	5	77:3384–3393	77:3384–3393	NUM
dti-1318	891	6	.	.	PUNCT
dti-1318	891	7	palella	palella	NOUN
dti-1318	891	8	,	,	PUNCT
dti-1318	891	9	f.j	f.j	PROPN
dti-1318	891	10	.	.	PROPN
dti-1318	891	11	,	,	PUNCT
dti-1318	891	12	jr	jr	PROPN
dti-1318	891	13	.	.	PROPN
dti-1318	891	14	,	,	PUNCT
dti-1318	891	15	delaney	delaney	PROPN
dti-1318	891	16	,	,	PUNCT
dti-1318	891	17	k.m	k.m	PROPN
dti-1318	891	18	.	.	PROPN
dti-1318	891	19	,	,	PUNCT
dti-1318	891	20	moorman	moorman	PROPN
dti-1318	891	21	,	,	PUNCT
dti-1318	891	22	a.c	a.c	PROPN
dti-1318	891	23	.	.	PROPN
dti-1318	891	24	,	,	PUNCT
dti-1318	891	25	loveless	loveless	ADJ
dti-1318	891	26	,	,	PUNCT
dti-1318	891	27	m.o	m.o	PROPN
dti-1318	891	28	.	.	PROPN
dti-1318	891	29	,	,	PUNCT
dti-1318	891	30	fuhrer	fuhrer	PROPN
dti-1318	891	31	,	,	PUNCT
dti-1318	891	32	j.	j.	PROPN
dti-1318	891	33	,	,	PUNCT
dti-1318	891	34	satten	satten	PROPN
dti-1318	891	35	,	,	PUNCT
dti-1318	891	36	g.a	g.a	PROPN
dti-1318	891	37	.	.	PROPN
dti-1318	891	38	,	,	PUNCT
dti-1318	891	39	aschman	aschman	PROPN
dti-1318	891	40	,	,	PUNCT
dti-1318	891	41	d.j	d.j	PROPN
dti-1318	891	42	.	.	PROPN
dti-1318	891	43	and	and	CCONJ
dti-1318	891	44	holmberg	holmberg	PROPN
dti-1318	891	45	,	,	PUNCT
dti-1318	891	46	s.d	s.d	PROPN
dti-1318	891	47	.	.	PROPN
dti-1318	891	48	1998	1998	NUM
dti-1318	891	49	.	.	PUNCT
dti-1318	892	1	declining	decline	VERB
dti-1318	892	2	morbidity	morbidity	NOUN
dti-1318	892	3	and	and	CCONJ
dti-1318	892	4	mortality	mortality	NOUN
dti-1318	892	5	among	among	ADP
dti-1318	892	6	patients	patient	NOUN
dti-1318	892	7	with	with	ADP
dti-1318	892	8	advanced	advanced	ADJ
dti-1318	892	9	human	human	ADJ
dti-1318	892	10	immunodefi	immunodefi	NOUN
dti-1318	892	11	ciency	ciency	NOUN
dti-1318	892	12	virus	virus	NOUN
dti-1318	892	13	infection	infection	NOUN
dti-1318	892	14	.	.	PUNCT
dti-1318	893	1	hiv	hiv	PROPN
dti-1318	893	2	outpatient	outpatient	NOUN
dti-1318	893	3	study	study	NOUN
dti-1318	893	4	investigators	investigator	NOUN
dti-1318	893	5	.	.	PUNCT
dti-1318	894	1	n.	n.	PROPN
dti-1318	894	2	engl	engl	PROPN
dti-1318	894	3	.	.	PUNCT
dti-1318	895	1	j.	j.	PROPN
dti-1318	895	2	med	med	PROPN
dti-1318	895	3	.	.	PROPN
dti-1318	895	4	,	,	PUNCT
dti-1318	895	5	338:853–860	338:853–860	NUM
dti-1318	895	6	.	.	PUNCT
dti-1318	896	1	parang	parang	PROPN
dti-1318	896	2	,	,	PUNCT
dti-1318	896	3	k.	k.	PROPN
dti-1318	896	4	,	,	PUNCT
dti-1318	896	5	wiebe	wiebe	PROPN
dti-1318	896	6	,	,	PUNCT
dti-1318	896	7	l.i	l.i	PROPN
dti-1318	896	8	.	.	PROPN
dti-1318	896	9	,	,	PUNCT
dti-1318	896	10	knaus	knaus	PROPN
dti-1318	896	11	,	,	PUNCT
dti-1318	896	12	e.e	e.e	PROPN
dti-1318	896	13	.	.	PROPN
dti-1318	896	14	,	,	PUNCT
dti-1318	896	15	huang	huang	PROPN
dti-1318	896	16	,	,	PUNCT
dti-1318	896	17	j.s	j.s	PROPN
dti-1318	896	18	.	.	PROPN
dti-1318	896	19	,	,	PUNCT
dti-1318	896	20	tyrrell	tyrrell	PROPN
dti-1318	896	21	,	,	PUNCT
dti-1318	896	22	d.l	d.l	PROPN
dti-1318	896	23	.	.	PROPN
dti-1318	896	24	and	and	CCONJ
dti-1318	896	25	csizmadia	csizmadia	PROPN
dti-1318	896	26	,	,	PUNCT
dti-1318	896	27	f.	f.	PROPN
dti-1318	896	28	1997	1997	NUM
dti-1318	896	29	.	.	PUNCT
dti-1318	897	1	in	in	ADP
dti-1318	897	2	vitro	vitro	X
dti-1318	897	3	antiviral	antiviral	ADJ
dti-1318	897	4	activities	activity	NOUN
dti-1318	897	5	of	of	ADP
dti-1318	897	6	myristic	myristic	ADJ
dti-1318	897	7	acid	acid	NOUN
dti-1318	897	8	analogs	analog	NOUN
dti-1318	897	9	against	against	ADP
dti-1318	897	10	human	human	ADJ
dti-1318	897	11	immunodefi	immunodefi	PROPN
dti-1318	897	12	ciency	ciency	NOUN
dti-1318	897	13	and	and	CCONJ
dti-1318	897	14	hepatitis	hepatitis	NOUN
dti-1318	897	15	b	b	PROPN
dti-1318	897	16	viruses	virus	NOUN
dti-1318	897	17	.	.	PUNCT
dti-1318	898	1	antiviral	antiviral	ADJ
dti-1318	898	2	res	re	NOUN
dti-1318	898	3	.	.	PUNCT
dti-1318	898	4	,	,	PUNCT
dti-1318	898	5	34:75–90	34:75–90	NUM
dti-1318	898	6	.	.	PUNCT
dti-1318	899	1	park	park	PROPN
dti-1318	899	2	,	,	PUNCT
dti-1318	899	3	j.	j.	PROPN
dti-1318	899	4	and	and	CCONJ
dti-1318	899	5	morrow	morrow	PROPN
dti-1318	899	6	,	,	PUNCT
dti-1318	899	7	c.d	c.d	PROPN
dti-1318	899	8	.	.	PROPN
dti-1318	899	9	1991	1991	NUM
dti-1318	899	10	.	.	PUNCT
dti-1318	900	1	overexpression	overexpression	NOUN
dti-1318	900	2	of	of	ADP
dti-1318	900	3	the	the	DET
dti-1318	900	4	gag	gag	NOUN
dti-1318	900	5	-	-	PUNCT
dti-1318	900	6	pol	pol	NOUN
dti-1318	900	7	precursor	precursor	NOUN
dti-1318	900	8	from	from	ADP
dti-1318	900	9	human	human	ADJ
dti-1318	900	10	immunodefi	immunodefi	PROPN
dti-1318	900	11	ciency	ciency	NOUN
dti-1318	900	12	virus	virus	NOUN
dti-1318	900	13	type	type	NOUN
dti-1318	900	14	1	1	NUM
dti-1318	900	15	proviral	proviral	NOUN
dti-1318	900	16	genomes	genome	NOUN
dti-1318	900	17	results	result	NOUN
dti-1318	900	18	in	in	ADP
dti-1318	900	19	effi	effi	PROPN
dti-1318	900	20	cient	cient	NOUN
dti-1318	900	21	proteolytic	proteolytic	ADJ
dti-1318	900	22	processing	processing	NOUN
dti-1318	900	23	in	in	ADP
dti-1318	900	24	the	the	DET
dti-1318	900	25	absence	absence	NOUN
dti-1318	900	26	of	of	ADP
dti-1318	900	27	virion	virion	NOUN
dti-1318	900	28	production	production	NOUN
dti-1318	900	29	.	.	PUNCT
dti-1318	901	1	j.	j.	PROPN
dti-1318	901	2	virol	virol	PROPN
dti-1318	901	3	.	.	PUNCT
dti-1318	901	4	,	,	PUNCT
dti-1318	901	5	65:5111–5117	65:5111–5117	NUM
dti-1318	901	6	.	.	PUNCT
dti-1318	901	7	park	park	PROPN
dti-1318	901	8	,	,	PUNCT
dti-1318	901	9	j.	j.	PROPN
dti-1318	901	10	and	and	CCONJ
dti-1318	901	11	morrow	morrow	PROPN
dti-1318	901	12	,	,	PUNCT
dti-1318	901	13	c.d	c.d	PROPN
dti-1318	901	14	.	.	PROPN
dti-1318	901	15	1992	1992	NUM
dti-1318	901	16	.	.	PUNCT
dti-1318	902	1	the	the	DET
dti-1318	902	2	nonmyristylated	nonmyristylated	ADJ
dti-1318	902	3	pr160gag	pr160gag	ADJ
dti-1318	902	4	-	-	PUNCT
dti-1318	902	5	pol	pol	NOUN
dti-1318	902	6	polyprotein	polyprotein	NOUN
dti-1318	902	7	of	of	ADP
dti-1318	902	8	human	human	ADJ
dti-1318	902	9	immunodefi	immunodefi	PROPN
dti-1318	902	10	ciency	ciency	NOUN
dti-1318	902	11	virus	virus	NOUN
dti-1318	902	12	type	type	NOUN
dti-1318	902	13	1	1	NUM
dti-1318	902	14	interacts	interact	VERB
dti-1318	902	15	with	with	ADP
dti-1318	902	16	pr55gag	pr55gag	NUM
dti-1318	902	17	and	and	CCONJ
dti-1318	902	18	is	be	AUX
dti-1318	902	19	incorporated	incorporate	VERB
dti-1318	902	20	into	into	ADP
dti-1318	902	21	virus	virus	NOUN
dti-1318	902	22	like	like	ADP
dti-1318	902	23	particles	particle	NOUN
dti-1318	902	24	.	.	PUNCT
dti-1318	903	1	j.	j.	PROPN
dti-1318	903	2	virol	virol	PROPN
dti-1318	903	3	.	.	PUNCT
dti-1318	903	4	,	,	PUNCT
dti-1318	903	5	66	66	NUM
dti-1318	903	6	:	:	PUNCT
dti-1318	903	7	6304–6313	6304–6313	NUM
dti-1318	903	8	.	.	PUNCT
dti-1318	903	9	park	park	PROPN
dti-1318	903	10	,	,	PUNCT
dti-1318	903	11	s.h	s.h	PROPN
dti-1318	903	12	.	.	PROPN
dti-1318	903	13	and	and	CCONJ
dti-1318	903	14	raines	raines	PROPN
dti-1318	903	15	,	,	PUNCT
dti-1318	903	16	r.t	r.t	PROPN
dti-1318	903	17	.	.	PROPN
dti-1318	903	18	2000	2000	NUM
dti-1318	903	19	.	.	PUNCT
dti-1318	904	1	genetic	genetic	ADJ
dti-1318	904	2	selection	selection	NOUN
dti-1318	904	3	for	for	ADP
dti-1318	904	4	dissociative	dissociative	ADJ
dti-1318	904	5	inhibitors	inhibitor	NOUN
dti-1318	904	6	of	of	ADP
dti-1318	904	7	designated	designate	VERB
dti-1318	904	8	protein	protein	NOUN
dti-1318	904	9	-	-	PUNCT
dti-1318	904	10	protein	protein	NOUN
dti-1318	904	11	interactions	interaction	NOUN
dti-1318	904	12	.	.	PUNCT
dti-1318	905	1	nat	nat	NOUN
dti-1318	905	2	.	.	PUNCT
dti-1318	906	1	biotechnol	biotechnol	PROPN
dti-1318	906	2	.	.	PUNCT
dti-1318	906	3	,	,	PUNCT
dti-1318	907	1	18:847–851	18:847–851	X
dti-1318	907	2	.	.	PUNCT
dti-1318	908	1	partin	partin	PROPN
dti-1318	908	2	,	,	PUNCT
dti-1318	908	3	k.	k.	PROPN
dti-1318	908	4	,	,	PUNCT
dti-1318	908	5	zybarth	zybarth	PROPN
dti-1318	908	6	,	,	PUNCT
dti-1318	908	7	g.	g.	PROPN
dti-1318	908	8	,	,	PUNCT
dti-1318	908	9	ehrlich	ehrlich	PROPN
dti-1318	908	10	,	,	PUNCT
dti-1318	908	11	l.	l.	PROPN
dti-1318	908	12	,	,	PUNCT
dti-1318	908	13	decrombrugghe	decrombrugghe	NOUN
dti-1318	908	14	,	,	PUNCT
dti-1318	908	15	m.	m.	NOUN
dti-1318	908	16	,	,	PUNCT
dti-1318	908	17	wimmer	wimmer	PROPN
dti-1318	908	18	,	,	PUNCT
dti-1318	908	19	e.	e.	PROPN
dti-1318	908	20	and	and	CCONJ
dti-1318	908	21	carter	carter	PROPN
dti-1318	908	22	,	,	PUNCT
dti-1318	908	23	c.	c.	PROPN
dti-1318	908	24	1991	1991	NUM
dti-1318	908	25	.	.	PUNCT
dti-1318	909	1	deletion	deletion	NOUN
dti-1318	909	2	of	of	ADP
dti-1318	909	3	sequences	sequence	NOUN
dti-1318	909	4	upstream	upstream	NOUN
dti-1318	909	5	of	of	ADP
dti-1318	909	6	the	the	DET
dti-1318	909	7	proteinase	proteinase	NOUN
dti-1318	909	8	improves	improve	VERB
dti-1318	909	9	the	the	DET
dti-1318	909	10	proteolytic	proteolytic	ADJ
dti-1318	909	11	processing	processing	NOUN
dti-1318	909	12	of	of	ADP
dti-1318	909	13	human	human	ADJ
dti-1318	909	14	immunodefi	immunodefi	PROPN
dti-1318	909	15	ciency	ciency	NOUN
dti-1318	909	16	virus	virus	NOUN
dti-1318	909	17	type	type	NOUN
dti-1318	909	18	1	1	NUM
dti-1318	909	19	.	.	PUNCT
dti-1318	909	20	proc	proc	PROPN
dti-1318	909	21	.	.	PUNCT
dti-1318	910	1	natl	natl	PROPN
dti-1318	910	2	.	.	PUNCT
dti-1318	911	1	acad	acad	PROPN
dti-1318	911	2	.	.	PUNCT
dti-1318	912	1	sci	sci	PROPN
dti-1318	912	2	.	.	PUNCT
dti-1318	912	3	u.s.a	u.s.a	PROPN
dti-1318	912	4	.	.	PROPN
dti-1318	912	5	,	,	PUNCT
dti-1318	912	6	88:4776–4780	88:4776–4780	NUM
dti-1318	912	7	.	.	PUNCT
dti-1318	913	1	pettit	pettit	PROPN
dti-1318	913	2	,	,	PUNCT
dti-1318	913	3	s.c	s.c	PROPN
dti-1318	913	4	.	.	PROPN
dti-1318	913	5	,	,	PUNCT
dti-1318	913	6	lindquist	lindquist	PROPN
dti-1318	913	7	,	,	PUNCT
dti-1318	913	8	j.n	j.n	PROPN
dti-1318	913	9	.	.	PROPN
dti-1318	913	10	,	,	PUNCT
dti-1318	913	11	kaplan	kaplan	PROPN
dti-1318	913	12	,	,	PUNCT
dti-1318	913	13	a.h	a.h	PROPN
dti-1318	913	14	.	.	PROPN
dti-1318	913	15	and	and	CCONJ
dti-1318	913	16	swanstrom	swanstrom	PROPN
dti-1318	913	17	,	,	PUNCT
dti-1318	913	18	r.	r.	PROPN
dti-1318	913	19	2005	2005	NUM
dti-1318	913	20	.	.	PUNCT
dti-1318	914	1	processing	process	VERB
dti-1318	914	2	sites	site	NOUN
dti-1318	914	3	in	in	ADP
dti-1318	914	4	the	the	DET
dti-1318	914	5	human	human	ADJ
dti-1318	914	6	immunodefi	immunodefi	PROPN
dti-1318	914	7	ciency	ciency	NOUN
dti-1318	914	8	virus	virus	NOUN
dti-1318	914	9	type	type	NOUN
dti-1318	914	10	1	1	NUM
dti-1318	914	11	(	(	PUNCT
dti-1318	914	12	hiv-1	hiv-1	NOUN
dti-1318	914	13	)	)	PUNCT
dti-1318	914	14	gag	gag	NOUN
dti-1318	914	15	-	-	PUNCT
dti-1318	914	16	pro	pro	ADJ
dti-1318	914	17	-	-	ADJ
dti-1318	914	18	pol	pol	ADJ
dti-1318	914	19	precursor	precursor	NOUN
dti-1318	914	20	are	be	AUX
dti-1318	914	21	cleaved	cleave	VERB
dti-1318	914	22	by	by	ADP
dti-1318	914	23	the	the	DET
dti-1318	914	24	viral	viral	ADJ
dti-1318	914	25	protease	protease	NOUN
dti-1318	914	26	at	at	ADP
dti-1318	914	27	different	different	ADJ
dti-1318	914	28	rates	rate	NOUN
dti-1318	914	29	.	.	PUNCT
dti-1318	915	1	retrovirology	retrovirology	NOUN
dti-1318	915	2	,	,	PUNCT
dti-1318	915	3	2:66	2:66	NUM
dti-1318	915	4	.	.	PUNCT
dti-1318	916	1	pettit	pettit	PROPN
dti-1318	916	2	,	,	PUNCT
dti-1318	916	3	s.c	s.c	PROPN
dti-1318	916	4	.	.	PROPN
dti-1318	916	5	,	,	PUNCT
dti-1318	916	6	moody	moody	PROPN
dti-1318	916	7	,	,	PUNCT
dti-1318	916	8	m.d	m.d	PROPN
dti-1318	916	9	.	.	PROPN
dti-1318	916	10	,	,	PUNCT
dti-1318	916	11	wehbie	wehbie	PROPN
dti-1318	916	12	,	,	PUNCT
dti-1318	916	13	r.s	r.s	PROPN
dti-1318	916	14	.	.	PROPN
dti-1318	916	15	,	,	PUNCT
dti-1318	916	16	kaplan	kaplan	PROPN
dti-1318	916	17	,	,	PUNCT
dti-1318	916	18	a.h	a.h	PROPN
dti-1318	916	19	.	.	PROPN
dti-1318	916	20	,	,	PUNCT
dti-1318	916	21	nantermet	nantermet	ADJ
dti-1318	916	22	,	,	PUNCT
dti-1318	916	23	p.v	p.v	PROPN
dti-1318	916	24	.	.	PROPN
dti-1318	916	25	,	,	PUNCT
dti-1318	916	26	klein	klein	PROPN
dti-1318	916	27	,	,	PUNCT
dti-1318	916	28	c.a	c.a	PROPN
dti-1318	916	29	.	.	PROPN
dti-1318	916	30	and	and	CCONJ
dti-1318	916	31	swanstrom	swanstrom	PROPN
dti-1318	916	32	,	,	PUNCT
dti-1318	916	33	r.	r.	PROPN
dti-1318	916	34	1994	1994	NUM
dti-1318	916	35	.	.	PUNCT
dti-1318	917	1	the	the	DET
dti-1318	917	2	p2	p2	PROPN
dti-1318	917	3	domain	domain	NOUN
dti-1318	917	4	of	of	ADP
dti-1318	917	5	human	human	ADJ
dti-1318	917	6	immunodefi	immunodefi	PROPN
dti-1318	917	7	ciency	ciency	NOUN
dti-1318	917	8	virus	virus	NOUN
dti-1318	917	9	type	type	NOUN
dti-1318	917	10	1	1	NUM
dti-1318	917	11	gag	gag	NOUN
dti-1318	917	12	regulates	regulate	VERB
dti-1318	917	13	sequential	sequential	ADJ
dti-1318	917	14	proteolytic	proteolytic	ADJ
dti-1318	917	15	processing	processing	NOUN
dti-1318	917	16	and	and	CCONJ
dti-1318	917	17	is	be	AUX
dti-1318	917	18	required	require	VERB
dti-1318	917	19	to	to	PART
dti-1318	917	20	produce	produce	VERB
dti-1318	917	21	fully	fully	ADV
dti-1318	917	22	infectious	infectious	ADJ
dti-1318	917	23	virions	virion	NOUN
dti-1318	917	24	.	.	PUNCT
dti-1318	918	1	j.	j.	PROPN
dti-1318	918	2	virol	virol	PROPN
dti-1318	918	3	.	.	PUNCT
dti-1318	918	4	,	,	PUNCT
dti-1318	918	5	68:8017–8027	68:8017–8027	NUM
dti-1318	918	6	.	.	PUNCT
dti-1318	919	1	pettit	pettit	PROPN
dti-1318	919	2	,	,	PUNCT
dti-1318	919	3	s.c	s.c	PROPN
dti-1318	919	4	.	.	PROPN
dti-1318	919	5	,	,	PUNCT
dti-1318	919	6	sheng	sheng	PROPN
dti-1318	919	7	,	,	PUNCT
dti-1318	919	8	n.	n.	NOUN
dti-1318	919	9	,	,	PUNCT
dti-1318	919	10	tritch	tritch	NOUN
dti-1318	919	11	,	,	PUNCT
dti-1318	919	12	r.	r.	PROPN
dti-1318	919	13	,	,	PUNCT
dti-1318	919	14	erickson	erickson	PROPN
dti-1318	919	15	-	-	PUNCT
dti-1318	919	16	viitanen	viitanen	PROPN
dti-1318	919	17	,	,	PUNCT
dti-1318	919	18	s.	s.	PROPN
dti-1318	919	19	and	and	CCONJ
dti-1318	919	20	swanstrom	swanstrom	PROPN
dti-1318	919	21	,	,	PUNCT
dti-1318	919	22	r.	r.	PROPN
dti-1318	919	23	1998	1998	NUM
dti-1318	919	24	.	.	PUNCT
dti-1318	920	1	the	the	DET
dti-1318	920	2	regulation	regulation	NOUN
dti-1318	920	3	of	of	ADP
dti-1318	920	4	sequential	sequential	ADJ
dti-1318	920	5	processing	processing	NOUN
dti-1318	920	6	of	of	ADP
dti-1318	920	7	hiv-1	hiv-1	X
dti-1318	920	8	gag	gag	NOUN
dti-1318	920	9	by	by	ADP
dti-1318	920	10	the	the	DET
dti-1318	920	11	viral	viral	ADJ
dti-1318	920	12	protease	protease	NOUN
dti-1318	920	13	.	.	PUNCT
dti-1318	921	1	adv	adv	PROPN
dti-1318	921	2	.	.	PUNCT
dti-1318	922	1	exp	exp	PROPN
dti-1318	922	2	.	.	PROPN
dti-1318	922	3	med	med	PROPN
dti-1318	922	4	.	.	PUNCT
dti-1318	923	1	biol	biol	PROPN
dti-1318	923	2	.	.	PUNCT
dti-1318	923	3	,	,	PUNCT
dti-1318	923	4	436:15–25	436:15–25	X
dti-1318	923	5	.	.	PUNCT
dti-1318	924	1	piacenti	piacenti	PROPN
dti-1318	924	2	,	,	PUNCT
dti-1318	924	3	f.j	f.j	PROPN
dti-1318	924	4	.	.	PROPN
dti-1318	924	5	2006	2006	NUM
dti-1318	924	6	.	.	PUNCT
dti-1318	925	1	an	an	DET
dti-1318	925	2	update	update	NOUN
dti-1318	925	3	and	and	CCONJ
dti-1318	925	4	review	review	NOUN
dti-1318	925	5	of	of	ADP
dti-1318	925	6	antiretroviral	antiretroviral	ADJ
dti-1318	925	7	therapy	therapy	NOUN
dti-1318	925	8	.	.	PUNCT
dti-1318	926	1	pharmacotherapy	pharmacotherapy	NOUN
dti-1318	926	2	,	,	PUNCT
dti-1318	926	3	26:1111–1133	26:1111–1133	PROPN
dti-1318	926	4	.	.	PUNCT
dti-1318	926	5	pidgeon	pidgeon	PROPN
dti-1318	926	6	,	,	PUNCT
dti-1318	926	7	c.	c.	PROPN
dti-1318	926	8	,	,	PUNCT
dti-1318	926	9	markovich	markovich	PROPN
dti-1318	926	10	,	,	PUNCT
dti-1318	926	11	r.j	r.j	PROPN
dti-1318	926	12	.	.	PROPN
dti-1318	926	13	,	,	PUNCT
dti-1318	926	14	liu	liu	PROPN
dti-1318	926	15	,	,	PUNCT
dti-1318	926	16	m.d	m.d	PROPN
dti-1318	926	17	.	.	PROPN
dti-1318	926	18	,	,	PUNCT
dti-1318	926	19	holzer	holzer	PROPN
dti-1318	926	20	,	,	PUNCT
dti-1318	926	21	t.j	t.j	PROPN
dti-1318	926	22	.	.	PROPN
dti-1318	926	23	,	,	PUNCT
dti-1318	926	24	novak	novak	PROPN
dti-1318	926	25	,	,	PUNCT
dti-1318	926	26	r.m	r.m	PROPN
dti-1318	926	27	.	.	PROPN
dti-1318	926	28	and	and	CCONJ
dti-1318	926	29	keyer	keyer	PROPN
dti-1318	926	30	,	,	PUNCT
dti-1318	926	31	k.a	k.a	PROPN
dti-1318	926	32	.	.	PROPN
dti-1318	926	33	1993	1993	NUM
dti-1318	926	34	.	.	PUNCT
dti-1318	927	1	antiviral	antiviral	ADJ
dti-1318	927	2	phospholipids	phospholipid	NOUN
dti-1318	927	3	.	.	PUNCT
dti-1318	928	1	anti	anti	ADJ
dti-1318	928	2	-	-	ADJ
dti-1318	928	3	hiv	hiv	ADJ
dti-1318	928	4	drugs	drug	NOUN
dti-1318	928	5	conjugated	conjugate	VERB
dti-1318	928	6	to	to	ADP
dti-1318	928	7	the	the	DET
dti-1318	928	8	glycerobackbone	glycerobackbone	NOUN
dti-1318	928	9	of	of	ADP
dti-1318	928	10	phospholipids	phospholipid	NOUN
dti-1318	928	11	.	.	PUNCT
dti-1318	929	1	j.	j.	PROPN
dti-1318	929	2	biol	biol	PROPN
dti-1318	929	3	.	.	PUNCT
dti-1318	930	1	chem	chem	PROPN
dti-1318	930	2	.	.	PUNCT
dti-1318	930	3	,	,	PUNCT
dti-1318	931	1	268	268	NUM
dti-1318	931	2	:	:	SYM
dti-1318	931	3	7773–7778	7773–7778	NUM
dti-1318	931	4	.	.	PUNCT
dti-1318	932	1	pornillos	pornillo	NOUN
dti-1318	932	2	,	,	PUNCT
dti-1318	932	3	o.	o.	PROPN
dti-1318	932	4	,	,	PUNCT
dti-1318	932	5	alam	alam	PROPN
dti-1318	932	6	,	,	PUNCT
dti-1318	932	7	s.l	s.l	PROPN
dti-1318	932	8	.	.	PROPN
dti-1318	932	9	,	,	PUNCT
dti-1318	932	10	davis	davis	PROPN
dti-1318	932	11	,	,	PUNCT
dti-1318	932	12	d.r	d.r	PROPN
dti-1318	932	13	.	.	PROPN
dti-1318	932	14	and	and	CCONJ
dti-1318	932	15	sundquist	sundquist	PROPN
dti-1318	932	16	,	,	PUNCT
dti-1318	932	17	w.i	w.i	PROPN
dti-1318	932	18	.	.	PROPN
dti-1318	932	19	2002a	2002a	NOUN
dti-1318	932	20	.	.	PUNCT
dti-1318	933	1	structure	structure	NOUN
dti-1318	933	2	of	of	ADP
dti-1318	933	3	the	the	DET
dti-1318	933	4	tsg101	tsg101	PROPN
dti-1318	933	5	uev	uev	NOUN
dti-1318	933	6	domain	domain	NOUN
dti-1318	933	7	in	in	ADP
dti-1318	933	8	complex	complex	NOUN
dti-1318	933	9	with	with	ADP
dti-1318	933	10	the	the	DET
dti-1318	933	11	ptap	ptap	ADJ
dti-1318	933	12	motif	motif	NOUN
dti-1318	933	13	of	of	ADP
dti-1318	933	14	the	the	DET
dti-1318	933	15	hiv-1	hiv-1	X
dti-1318	933	16	p6	p6	ADJ
dti-1318	933	17	protein	protein	NOUN
dti-1318	933	18	.	.	PUNCT
dti-1318	934	1	nat	nat	PROPN
dti-1318	934	2	.	.	PUNCT
dti-1318	934	3	struct	struct	NOUN
dti-1318	934	4	.	.	PUNCT
dti-1318	935	1	biol	biol	PROPN
dti-1318	935	2	.	.	PUNCT
dti-1318	935	3	,	,	PUNCT
dti-1318	935	4	9:812–817	9:812–817	NOUN
dti-1318	935	5	.	.	PUNCT
dti-1318	936	1	pornillos	pornillo	NOUN
dti-1318	936	2	,	,	PUNCT
dti-1318	936	3	o.	o.	PROPN
dti-1318	936	4	,	,	PUNCT
dti-1318	936	5	alam	alam	PROPN
dti-1318	936	6	,	,	PUNCT
dti-1318	936	7	s.l	s.l	PROPN
dti-1318	936	8	.	.	PROPN
dti-1318	936	9	,	,	PUNCT
dti-1318	936	10	rich	rich	ADJ
dti-1318	936	11	,	,	PUNCT
dti-1318	936	12	r.l	r.l	PROPN
dti-1318	936	13	.	.	PROPN
dti-1318	936	14	,	,	PUNCT
dti-1318	936	15	myszka	myszka	PROPN
dti-1318	936	16	,	,	PUNCT
dti-1318	936	17	d.g	d.g	PROPN
dti-1318	936	18	.	.	PROPN
dti-1318	936	19	,	,	PUNCT
dti-1318	936	20	davis	davis	PROPN
dti-1318	936	21	,	,	PUNCT
dti-1318	936	22	d.r	d.r	PROPN
dti-1318	936	23	.	.	PROPN
dti-1318	936	24	and	and	CCONJ
dti-1318	936	25	sundquist	sundquist	PROPN
dti-1318	936	26	,	,	PUNCT
dti-1318	936	27	w.i	w.i	PROPN
dti-1318	936	28	.	.	PROPN
dti-1318	936	29	2002b	2002b	NUM
dti-1318	936	30	.	.	PUNCT
dti-1318	937	1	structure	structure	NOUN
dti-1318	937	2	and	and	CCONJ
dti-1318	937	3	functional	functional	ADJ
dti-1318	937	4	interactions	interaction	NOUN
dti-1318	937	5	of	of	ADP
dti-1318	937	6	the	the	DET
dti-1318	937	7	tsg101	tsg101	PROPN
dti-1318	937	8	uev	uev	NOUN
dti-1318	937	9	domain	domain	NOUN
dti-1318	937	10	.	.	PUNCT
dti-1318	938	1	embo	embo	PROPN
dti-1318	938	2	j.	j.	PROPN
dti-1318	938	3	,	,	PUNCT
dti-1318	938	4	21:2397–2406	21:2397–2406	PROPN
dti-1318	938	5	.	.	PUNCT
dti-1318	938	6	pornillos	pornillo	NOUN
dti-1318	938	7	,	,	PUNCT
dti-1318	938	8	o.	o.	PROPN
dti-1318	938	9	,	,	PUNCT
dti-1318	938	10	higginson	higginson	PROPN
dti-1318	938	11	,	,	PUNCT
dti-1318	938	12	d.s	d.s	PROPN
dti-1318	938	13	.	.	PROPN
dti-1318	938	14	,	,	PUNCT
dti-1318	938	15	stray	stray	VERB
dti-1318	938	16	,	,	PUNCT
dti-1318	938	17	k.m	k.m	PROPN
dti-1318	938	18	.	.	PROPN
dti-1318	938	19	,	,	PUNCT
dti-1318	938	20	fisher	fisher	PROPN
dti-1318	938	21	,	,	PUNCT
dti-1318	938	22	r.d	r.d	PROPN
dti-1318	938	23	.	.	PROPN
dti-1318	938	24	,	,	PUNCT
dti-1318	938	25	garrus	garrus	PROPN
dti-1318	938	26	,	,	PUNCT
dti-1318	938	27	j.e	j.e	PROPN
dti-1318	938	28	.	.	PROPN
dti-1318	938	29	,	,	PUNCT
dti-1318	938	30	payne	payne	PROPN
dti-1318	938	31	,	,	PUNCT
dti-1318	938	32	m.	m.	NOUN
dti-1318	938	33	,	,	PUNCT
dti-1318	938	34	he	he	PRON
dti-1318	938	35	,	,	PUNCT
dti-1318	938	36	g.p	g.p	PROPN
dti-1318	938	37	.	.	PROPN
dti-1318	938	38	,	,	PUNCT
dti-1318	938	39	wang	wang	PROPN
dti-1318	938	40	,	,	PUNCT
dti-1318	938	41	h.e	h.e	PROPN
dti-1318	938	42	.	.	PROPN
dti-1318	938	43	,	,	PUNCT
dti-1318	938	44	morham	morham	PROPN
dti-1318	938	45	,	,	PUNCT
dti-1318	938	46	s.g	s.g	PROPN
dti-1318	938	47	.	.	PROPN
dti-1318	938	48	and	and	CCONJ
dti-1318	938	49	sundquist	sundquist	PROPN
dti-1318	938	50	,	,	PUNCT
dti-1318	938	51	w.i	w.i	PROPN
dti-1318	938	52	.	.	PROPN
dti-1318	938	53	2003	2003	NUM
dti-1318	938	54	.	.	PUNCT
dti-1318	939	1	hiv	hiv	PROPN
dti-1318	939	2	gag	gag	PROPN
dti-1318	939	3	mimics	mimic	VERB
dti-1318	939	4	the	the	DET
dti-1318	939	5	tsg101	tsg101	PROPN
dti-1318	939	6	-	-	PUNCT
dti-1318	939	7	recruiting	recruit	VERB
dti-1318	939	8	activity	activity	NOUN
dti-1318	939	9	of	of	ADP
dti-1318	939	10	the	the	DET
dti-1318	939	11	human	human	ADJ
dti-1318	939	12	hrs	hrs	NOUN
dti-1318	939	13	protein	protein	NOUN
dti-1318	939	14	.	.	PUNCT
dti-1318	940	1	j.	j.	PROPN
dti-1318	940	2	cell	cell	PROPN
dti-1318	940	3	biol	biol	PROPN
dti-1318	940	4	.	.	PUNCT
dti-1318	940	5	,	,	PUNCT
dti-1318	940	6	162:425–434	162:425–434	NUM
dti-1318	940	7	.	.	PUNCT
dti-1318	941	1	potts	potts	PROPN
dti-1318	941	2	,	,	PUNCT
dti-1318	941	3	b.c.m	b.c.m	PROPN
dti-1318	941	4	.	.	PROPN
dti-1318	941	5	,	,	PUNCT
dti-1318	941	6	faulkner	faulkner	PROPN
dti-1318	941	7	,	,	PUNCT
dti-1318	941	8	d.j	d.j	PROPN
dti-1318	941	9	.	.	PROPN
dti-1318	941	10	,	,	PUNCT
dti-1318	941	11	chan	chan	PROPN
dti-1318	941	12	,	,	PUNCT
dti-1318	941	13	j.a	j.a	PROPN
dti-1318	941	14	.	.	PROPN
dti-1318	941	15	,	,	PUNCT
dti-1318	941	16	simolike	simolike	NOUN
dti-1318	941	17	,	,	PUNCT
dti-1318	941	18	g.c	g.c	PROPN
dti-1318	941	19	.	.	PROPN
dti-1318	941	20	,	,	PUNCT
dti-1318	941	21	offen	offen	PROPN
dti-1318	941	22	,	,	PUNCT
dti-1318	941	23	p.	p.	NOUN
dti-1318	941	24	,	,	PUNCT
dti-1318	941	25	hemling	hemling	NOUN
dti-1318	941	26	,	,	PUNCT
dti-1318	941	27	m.e	m.e	PROPN
dti-1318	941	28	.	.	PROPN
dti-1318	941	29	and	and	CCONJ
dti-1318	941	30	francis	francis	PROPN
dti-1318	941	31	,	,	PUNCT
dti-1318	941	32	t.e	t.e	PROPN
dti-1318	941	33	.	.	PROPN
dti-1318	941	34	1991	1991	NUM
dti-1318	941	35	.	.	PUNCT
dti-1318	942	1	didemnaketal	didemnaketal	ADJ
dti-1318	942	2	a	a	PRON
dti-1318	942	3	and	and	CCONJ
dti-1318	942	4	b	b	NOUN
dti-1318	942	5	,	,	PUNCT
dti-1318	942	6	hiv-1	hiv-1	X
dti-1318	942	7	protease	protease	NOUN
dti-1318	942	8	inhibitors	inhibitor	NOUN
dti-1318	942	9	from	from	ADP
dti-1318	942	10	the	the	DET
dti-1318	942	11	accidian	accidian	PROPN
dti-1318	942	12	didemnum	didemnum	PROPN
dti-1318	942	13	sp	sp	PROPN
dti-1318	942	14	.	.	PROPN
dti-1318	942	15	journal	journal	PROPN
dti-1318	942	16	of	of	ADP
dti-1318	942	17	the	the	DET
dti-1318	942	18	american	american	PROPN
dti-1318	942	19	chemical	chemical	PROPN
dti-1318	942	20	society	society	PROPN
dti-1318	942	21	,	,	PUNCT
dti-1318	942	22	113:6321–6322	113:6321–6322	PROPN
dti-1318	942	23	.	.	PUNCT
dti-1318	943	1	quere	quere	PROPN
dti-1318	943	2	,	,	PUNCT
dti-1318	943	3	l.	l.	PROPN
dti-1318	943	4	,	,	PUNCT
dti-1318	943	5	wenger	wenger	PROPN
dti-1318	943	6	,	,	PUNCT
dti-1318	943	7	t.	t.	PROPN
dti-1318	943	8	and	and	CCONJ
dti-1318	943	9	schramm	schramm	PROPN
dti-1318	943	10	,	,	PUNCT
dti-1318	943	11	h.j	h.j	PROPN
dti-1318	943	12	.	.	PROPN
dti-1318	943	13	1996	1996	NUM
dti-1318	943	14	.	.	PUNCT
dti-1318	944	1	triterpenes	triterpene	NOUN
dti-1318	944	2	as	as	ADP
dti-1318	944	3	potential	potential	ADJ
dti-1318	944	4	dimerization	dimerization	NOUN
dti-1318	944	5	inhibitors	inhibitor	NOUN
dti-1318	944	6	of	of	ADP
dti-1318	944	7	hiv-1	hiv-1	X
dti-1318	944	8	protease	protease	NOUN
dti-1318	944	9	.	.	PUNCT
dti-1318	945	1	biochem	biochem	PROPN
dti-1318	945	2	.	.	PUNCT
dti-1318	946	1	biophys	biophy	NOUN
dti-1318	946	2	.	.	PUNCT
dti-1318	947	1	res	re	NOUN
dti-1318	947	2	.	.	PUNCT
dti-1318	948	1	commun	commun	PROPN
dti-1318	948	2	.	.	PROPN
dti-1318	948	3	,	,	PUNCT
dti-1318	949	1	227:484–488	227:484–488	NUM
dti-1318	949	2	.	.	PUNCT
dti-1318	950	1	quillent	quillent	PROPN
dti-1318	950	2	,	,	PUNCT
dti-1318	950	3	c.	c.	PROPN
dti-1318	950	4	,	,	PUNCT
dti-1318	950	5	borman	borman	NOUN
dti-1318	950	6	,	,	PUNCT
dti-1318	950	7	a.m.	a.m.	ADV
dti-1318	950	8	,	,	PUNCT
dti-1318	950	9	paulous	paulous	ADJ
dti-1318	950	10	,	,	PUNCT
dti-1318	950	11	s.	s.	PROPN
dti-1318	950	12	,	,	PUNCT
dti-1318	950	13	dauguet	dauguet	PROPN
dti-1318	950	14	,	,	PUNCT
dti-1318	950	15	c.	c.	PROPN
dti-1318	950	16	and	and	CCONJ
dti-1318	950	17	clavel	clavel	PROPN
dti-1318	950	18	,	,	PUNCT
dti-1318	950	19	f.	f.	PROPN
dti-1318	950	20	1996	1996	NUM
dti-1318	950	21	.	.	PUNCT
dti-1318	951	1	extensive	extensive	ADJ
dti-1318	951	2	regions	region	NOUN
dti-1318	951	3	of	of	ADP
dti-1318	951	4	pol	pol	NOUN
dti-1318	951	5	are	be	AUX
dti-1318	951	6	required	require	VERB
dti-1318	951	7	for	for	ADP
dti-1318	951	8	effi	effi	PROPN
dti-1318	951	9	cient	cient	PROPN
dti-1318	951	10	human	human	PROPN
dti-1318	951	11	immunodefi	immunodefi	PROPN
dti-1318	951	12	ciency	ciency	NOUN
dti-1318	951	13	virus	virus	NOUN
dti-1318	951	14	polyprotein	polyprotein	ADJ
dti-1318	951	15	processing	processing	NOUN
dti-1318	951	16	and	and	CCONJ
dti-1318	951	17	particle	particle	NOUN
dti-1318	951	18	maturation	maturation	NOUN
dti-1318	951	19	.	.	PUNCT
dti-1318	952	1	virology	virology	NOUN
dti-1318	952	2	,	,	PUNCT
dti-1318	952	3	219:29–36	219:29–36	NUM
dti-1318	952	4	.	.	PUNCT
dti-1318	953	1	rabson	rabson	PROPN
dti-1318	953	2	,	,	PUNCT
dti-1318	953	3	a.b	a.b	PROPN
dti-1318	953	4	.	.	PROPN
dti-1318	953	5	and	and	CCONJ
dti-1318	953	6	graves	grave	NOUN
dti-1318	953	7	,	,	PUNCT
dti-1318	953	8	b.j	b.j	PROPN
dti-1318	953	9	.	.	PROPN
dti-1318	953	10	1997	1997	NUM
dti-1318	953	11	.	.	PUNCT
dti-1318	954	1	synthesis	synthesis	NOUN
dti-1318	954	2	and	and	CCONJ
dti-1318	954	3	processing	processing	NOUN
dti-1318	954	4	of	of	ADP
dti-1318	954	5	viral	viral	ADJ
dti-1318	954	6	rna	rna	NOUN
dti-1318	954	7	.	.	PUNCT
dti-1318	955	1	in	in	ADP
dti-1318	955	2	coffi	coffi	PROPN
dti-1318	955	3	n	n	CCONJ
dti-1318	955	4	,	,	PUNCT
dti-1318	955	5	j.m	j.m	PROPN
dti-1318	955	6	.	.	PROPN
dti-1318	955	7	,	,	PUNCT
dti-1318	955	8	hughes	hughes	PROPN
dti-1318	955	9	,	,	PUNCT
dti-1318	955	10	s.	s.	PROPN
dti-1318	955	11	h.	h.	PROPN
dti-1318	955	12	&	&	CCONJ
dti-1318	955	13	varmus	varmus	PROPN
dti-1318	955	14	,	,	PUNCT
dti-1318	955	15	h.e	h.e	PROPN
dti-1318	956	1	.	.	PROPN
dti-1318	956	2	ed	ed	NOUN
dti-1318	956	3	.	.	PUNCT
dti-1318	957	1	retroviruses	retrovirus	NOUN
dti-1318	957	2	.	.	PUNCT
dti-1318	958	1	new	new	PROPN
dti-1318	958	2	york	york	PROPN
dti-1318	958	3	,	,	PUNCT
dti-1318	958	4	cold	cold	ADJ
dti-1318	958	5	spring	spring	NOUN
dti-1318	958	6	harbor	harbor	NOUN
dti-1318	958	7	laboratory	laboratory	PROPN
dti-1318	958	8	press	press	PROPN
dti-1318	958	9	.	.	PUNCT
dti-1318	959	1	reicin	reicin	PROPN
dti-1318	959	2	,	,	PUNCT
dti-1318	959	3	a.s	a.s	PROPN
dti-1318	959	4	.	.	PROPN
dti-1318	959	5	,	,	PUNCT
dti-1318	959	6	ohagen	ohagen	PROPN
dti-1318	959	7	,	,	PUNCT
dti-1318	959	8	a.	a.	PROPN
dti-1318	959	9	,	,	PUNCT
dti-1318	959	10	yin	yin	PROPN
dti-1318	959	11	,	,	PUNCT
dti-1318	959	12	l.	l.	PROPN
dti-1318	959	13	,	,	PUNCT
dti-1318	959	14	hoglund	hoglund	PROPN
dti-1318	959	15	,	,	PUNCT
dti-1318	959	16	s.	s.	PROPN
dti-1318	959	17	and	and	CCONJ
dti-1318	959	18	goff	goff	PROPN
dti-1318	959	19	,	,	PUNCT
dti-1318	959	20	s.p	s.p	PROPN
dti-1318	959	21	.	.	PROPN
dti-1318	959	22	1996	1996	NUM
dti-1318	959	23	.	.	PUNCT
dti-1318	960	1	the	the	DET
dti-1318	960	2	role	role	NOUN
dti-1318	960	3	of	of	ADP
dti-1318	960	4	gag	gag	NOUN
dti-1318	960	5	in	in	ADP
dti-1318	960	6	human	human	ADJ
dti-1318	960	7	immunodefi	immunodefi	PROPN
dti-1318	960	8	ciency	ciency	NOUN
dti-1318	960	9	virus	virus	NOUN
dti-1318	960	10	type	type	NOUN
dti-1318	960	11	1	1	NUM
dti-1318	960	12	virion	virion	NOUN
dti-1318	960	13	morphogenesis	morphogenesis	NOUN
dti-1318	960	14	and	and	CCONJ
dti-1318	960	15	early	early	ADJ
dti-1318	960	16	steps	step	NOUN
dti-1318	960	17	of	of	ADP
dti-1318	960	18	the	the	DET
dti-1318	960	19	viral	viral	ADJ
dti-1318	960	20	life	life	NOUN
dti-1318	960	21	cycle	cycle	NOUN
dti-1318	960	22	.	.	PUNCT
dti-1318	961	1	j.	j.	PROPN
dti-1318	961	2	virol	virol	PROPN
dti-1318	961	3	.	.	PUNCT
dti-1318	961	4	,	,	PUNCT
dti-1318	962	1	70:8645–8652	70:8645–8652	PROPN
dti-1318	962	2	.	.	PUNCT
dti-1318	963	1	180	180	NUM
dti-1318	963	2	wapling	waple	VERB
dti-1318	963	3	et	et	PROPN
dti-1318	963	4	al	al	PROPN
dti-1318	963	5	drug	drug	PROPN
dti-1318	963	6	target	target	NOUN
dti-1318	963	7	insights	insight	NOUN
dti-1318	963	8	2007	2007	NUM
dti-1318	963	9	:	:	PUNCT
dti-1318	963	10	2	2	NUM
dti-1318	963	11	rice	rice	NOUN
dti-1318	963	12	,	,	PUNCT
dti-1318	963	13	w.g	w.g	PROPN
dti-1318	963	14	.	.	PROPN
dti-1318	963	15	,	,	PUNCT
dti-1318	963	16	baker	baker	PROPN
dti-1318	963	17	,	,	PUNCT
dti-1318	963	18	d.c	d.c	PROPN
dti-1318	963	19	.	.	PROPN
dti-1318	963	20	,	,	PUNCT
dti-1318	963	21	schaeffer	schaeffer	PROPN
dti-1318	963	22	,	,	PUNCT
dti-1318	963	23	c.a	c.a	PROPN
dti-1318	963	24	.	.	PROPN
dti-1318	963	25	,	,	PUNCT
dti-1318	963	26	graham	graham	PROPN
dti-1318	963	27	,	,	PUNCT
dti-1318	963	28	l.	l.	PROPN
dti-1318	963	29	,	,	PUNCT
dti-1318	963	30	bu	bu	PROPN
dti-1318	963	31	,	,	PUNCT
dti-1318	963	32	m.	m.	NOUN
dti-1318	963	33	,	,	PUNCT
dti-1318	963	34	terpening	terpening	NOUN
dti-1318	963	35	,	,	PUNCT
dti-1318	963	36	s.	s.	PROPN
dti-1318	963	37	,	,	PUNCT
dti-1318	963	38	clanton	clanton	PROPN
dti-1318	963	39	,	,	PUNCT
dti-1318	963	40	d.	d.	PROPN
dti-1318	963	41	,	,	PUNCT
dti-1318	963	42	schultz	schultz	PROPN
dti-1318	963	43	,	,	PUNCT
dti-1318	963	44	r.	r.	PROPN
dti-1318	963	45	,	,	PUNCT
dti-1318	963	46	bader	bader	PROPN
dti-1318	963	47	,	,	PUNCT
dti-1318	963	48	j.p	j.p	PROPN
dti-1318	963	49	.	.	PROPN
dti-1318	963	50	,	,	PUNCT
dti-1318	963	51	buckheit	buckheit	PROPN
dti-1318	963	52	,	,	PUNCT
dti-1318	963	53	r.w	r.w	PROPN
dti-1318	963	54	.	.	PROPN
dti-1318	963	55	,	,	PUNCT
dti-1318	963	56	jr	jr	PROPN
dti-1318	963	57	.	.	PROPN
dti-1318	963	58	,	,	PUNCT
dti-1318	963	59	field	field	NOUN
dti-1318	963	60	,	,	PUNCT
dti-1318	963	61	l.	l.	PROPN
dti-1318	963	62	,	,	PUNCT
dti-1318	963	63	singh	singh	PROPN
dti-1318	963	64	,	,	PUNCT
dti-1318	963	65	p.k	p.k	PROPN
dti-1318	963	66	.	.	PROPN
dti-1318	963	67	and	and	CCONJ
dti-1318	963	68	turpin	turpin	PROPN
dti-1318	963	69	,	,	PUNCT
dti-1318	963	70	j.a	j.a	PROPN
dti-1318	963	71	.	.	PROPN
dti-1318	963	72	1997	1997	NUM
dti-1318	963	73	.	.	PUNCT
dti-1318	964	1	inhibition	inhibition	NOUN
dti-1318	964	2	of	of	ADP
dti-1318	964	3	multiple	multiple	ADJ
dti-1318	964	4	phases	phase	NOUN
dti-1318	964	5	of	of	ADP
dti-1318	964	6	human	human	ADJ
dti-1318	964	7	immunodefi	immunodefi	PROPN
dti-1318	964	8	ciency	ciency	NOUN
dti-1318	964	9	virus	virus	NOUN
dti-1318	964	10	type	type	NOUN
dti-1318	964	11	1	1	NUM
dti-1318	964	12	replication	replication	NOUN
dti-1318	964	13	by	by	ADP
dti-1318	964	14	a	a	DET
dti-1318	964	15	dithiane	dithiane	NOUN
dti-1318	964	16	compound	compound	NOUN
dti-1318	964	17	that	that	PRON
dti-1318	964	18	attacks	attack	VERB
dti-1318	964	19	the	the	DET
dti-1318	964	20	conserved	conserved	ADJ
dti-1318	964	21	zinc	zinc	NOUN
dti-1318	964	22	fingers	finger	NOUN
dti-1318	964	23	of	of	ADP
dti-1318	964	24	retroviral	retroviral	ADJ
dti-1318	964	25	nucleocapsid	nucleocapsid	ADJ
dti-1318	964	26	proteins	protein	NOUN
dti-1318	964	27	.	.	PUNCT
dti-1318	965	1	antimicrob	antimicrob	PROPN
dti-1318	965	2	.	.	PUNCT
dti-1318	966	1	agents	agents	PROPN
dti-1318	966	2	chemother	chemother	PROPN
dti-1318	966	3	.	.	PUNCT
dti-1318	966	4	,	,	PUNCT
dti-1318	966	5	41:419–426	41:419–426	PROPN
dti-1318	966	6	.	.	PUNCT
dti-1318	967	1	rice	rice	PROPN
dti-1318	967	2	,	,	PUNCT
dti-1318	967	3	w.g	w.g	PROPN
dti-1318	967	4	.	.	PROPN
dti-1318	967	5	,	,	PUNCT
dti-1318	967	6	supko	supko	VERB
dti-1318	967	7	,	,	PUNCT
dti-1318	967	8	j.g	j.g	PROPN
dti-1318	967	9	.	.	PROPN
dti-1318	967	10	,	,	PUNCT
dti-1318	967	11	malspeis	malspeis	PROPN
dti-1318	967	12	,	,	PUNCT
dti-1318	967	13	l.	l.	PROPN
dti-1318	967	14	,	,	PUNCT
dti-1318	967	15	buckheit	buckheit	PROPN
dti-1318	967	16	,	,	PUNCT
dti-1318	967	17	r.w	r.w	PROPN
dti-1318	967	18	.	.	PROPN
dti-1318	967	19	,	,	PUNCT
dti-1318	967	20	jr	jr	PROPN
dti-1318	967	21	.	.	PROPN
dti-1318	967	22	,	,	PUNCT
dti-1318	967	23	clanton	clanton	PROPN
dti-1318	967	24	,	,	PUNCT
dti-1318	967	25	d.	d.	PROPN
dti-1318	967	26	,	,	PUNCT
dti-1318	967	27	bu	bu	PROPN
dti-1318	967	28	,	,	PUNCT
dti-1318	967	29	m.	m.	NOUN
dti-1318	967	30	,	,	PUNCT
dti-1318	967	31	graham	graham	PROPN
dti-1318	967	32	,	,	PUNCT
dti-1318	967	33	l.	l.	PROPN
dti-1318	967	34	,	,	PUNCT
dti-1318	967	35	schaeffer	schaeffer	PROPN
dti-1318	967	36	,	,	PUNCT
dti-1318	967	37	c.a	c.a	PROPN
dti-1318	967	38	.	.	PROPN
dti-1318	967	39	,	,	PUNCT
dti-1318	967	40	turpin	turpin	PROPN
dti-1318	967	41	,	,	PUNCT
dti-1318	967	42	j.a	j.a	PROPN
dti-1318	967	43	.	.	PROPN
dti-1318	967	44	,	,	PUNCT
dti-1318	967	45	domagala	domagala	PROPN
dti-1318	967	46	,	,	PUNCT
dti-1318	967	47	j.	j.	PROPN
dti-1318	967	48	,	,	PUNCT
dti-1318	967	49	gogliotti	gogliotti	PROPN
dti-1318	967	50	,	,	PUNCT
dti-1318	967	51	r.	r.	PROPN
dti-1318	967	52	,	,	PUNCT
dti-1318	967	53	bader	bader	PROPN
dti-1318	967	54	,	,	PUNCT
dti-1318	967	55	j.p	j.p	PROPN
dti-1318	967	56	.	.	PROPN
dti-1318	967	57	,	,	PUNCT
dti-1318	967	58	halliday	halliday	PROPN
dti-1318	967	59	,	,	PUNCT
dti-1318	967	60	s.m	s.m	PROPN
dti-1318	967	61	.	.	PROPN
dti-1318	967	62	,	,	PUNCT
dti-1318	967	63	coren	coren	PROPN
dti-1318	967	64	,	,	PUNCT
dti-1318	967	65	l.	l.	PROPN
dti-1318	967	66	,	,	PUNCT
dti-1318	967	67	sowder	sowder	NOUN
dti-1318	967	68	,	,	PUNCT
dti-1318	967	69	r.c	r.c	PROPN
dti-1318	967	70	.	.	PROPN
dti-1318	967	71	,	,	PUNCT
dti-1318	967	72	arthur	arthur	PROPN
dti-1318	967	73	,	,	PUNCT
dti-1318	967	74	l.o	l.o	PROPN
dti-1318	967	75	.	.	PROPN
dti-1318	967	76	and	and	CCONJ
dti-1318	967	77	henderson	henderson	PROPN
dti-1318	967	78	,	,	PUNCT
dti-1318	967	79	l.e	l.e	PROPN
dti-1318	967	80	.	.	PROPN
dti-1318	967	81	1995	1995	NUM
dti-1318	967	82	.	.	PUNCT
dti-1318	968	1	inhibitors	inhibitor	NOUN
dti-1318	968	2	of	of	ADP
dti-1318	968	3	hiv	hiv	PROPN
dti-1318	968	4	nucleocapsid	nucleocapsid	ADJ
dti-1318	968	5	protein	protein	NOUN
dti-1318	968	6	zinc	zinc	NOUN
dti-1318	968	7	fingers	finger	NOUN
dti-1318	968	8	as	as	ADP
dti-1318	968	9	candidates	candidate	NOUN
dti-1318	968	10	for	for	ADP
dti-1318	968	11	the	the	DET
dti-1318	968	12	treatment	treatment	NOUN
dti-1318	968	13	of	of	ADP
dti-1318	968	14	aids	aids	PROPN
dti-1318	968	15	.	.	PUNCT
dti-1318	969	1	science	science	NOUN
dti-1318	969	2	,	,	PUNCT
dti-1318	969	3	270:1194–1197	270:1194–1197	PRON
dti-1318	969	4	.	.	PUNCT
dti-1318	970	1	rodriguez	rodriguez	NOUN
dti-1318	970	2	-	-	PUNCT
dti-1318	970	3	barrios	barrios	PROPN
dti-1318	970	4	,	,	PUNCT
dti-1318	970	5	f.	f.	PROPN
dti-1318	970	6	,	,	PUNCT
dti-1318	970	7	perez	perez	PROPN
dti-1318	970	8	,	,	PUNCT
dti-1318	970	9	c.	c.	PROPN
dti-1318	970	10	,	,	PUNCT
dti-1318	970	11	lobaton	lobaton	PROPN
dti-1318	970	12	,	,	PUNCT
dti-1318	970	13	e.	e.	PROPN
dti-1318	970	14	,	,	PUNCT
dti-1318	970	15	velazquez	velazquez	PROPN
dti-1318	970	16	,	,	PUNCT
dti-1318	970	17	s.	s.	PROPN
dti-1318	970	18	,	,	PUNCT
dti-1318	970	19	chamorro	chamorro	PROPN
dti-1318	970	20	,	,	PUNCT
dti-1318	970	21	c.	c.	PROPN
dti-1318	970	22	,	,	PUNCT
dti-1318	970	23	san	san	PROPN
dti-1318	970	24	-	-	PUNCT
dti-1318	970	25	felix	felix	PROPN
dti-1318	970	26	,	,	PUNCT
dti-1318	970	27	a.	a.	NOUN
dti-1318	970	28	,	,	PUNCT
dti-1318	970	29	perez	perez	PROPN
dti-1318	970	30	-	-	PUNCT
dti-1318	970	31	perez	perez	PROPN
dti-1318	970	32	,	,	PUNCT
dti-1318	970	33	m.j	m.j	PROPN
dti-1318	970	34	.	.	PROPN
dti-1318	970	35	,	,	PUNCT
dti-1318	970	36	camarasa	camarasa	PROPN
dti-1318	970	37	,	,	PUNCT
dti-1318	970	38	m.j	m.j	PROPN
dti-1318	970	39	.	.	PROPN
dti-1318	970	40	,	,	PUNCT
dti-1318	970	41	pelemans	peleman	NOUN
dti-1318	970	42	,	,	PUNCT
dti-1318	970	43	h.	h.	PROPN
dti-1318	970	44	,	,	PUNCT
dti-1318	970	45	balzarini	balzarini	PROPN
dti-1318	970	46	,	,	PUNCT
dti-1318	970	47	j.	j.	PROPN
dti-1318	970	48	and	and	CCONJ
dti-1318	970	49	gago	gago	PROPN
dti-1318	970	50	,	,	PUNCT
dti-1318	970	51	f.	f.	PROPN
dti-1318	970	52	2001	2001	NUM
dti-1318	970	53	.	.	PUNCT
dti-1318	971	1	identifi	identifi	PROPN
dti-1318	971	2	cation	cation	NOUN
dti-1318	971	3	of	of	ADP
dti-1318	971	4	a	a	DET
dti-1318	971	5	putative	putative	ADJ
dti-1318	971	6	binding	bind	VERB
dti-1318	971	7	site	site	NOUN
dti-1318	971	8	for	for	ADP
dti-1318	971	9	[	[	X
dti-1318	971	10	2′,5′-bis	2′,5′-bis	ADJ
dti-1318	971	11	-	-	ADJ
dti-1318	971	12	o-(tert	o-(tert	PROPN
dti-1318	971	13	-	-	PUNCT
dti-1318	971	14	butyldimethylsilyl)-beta	butyldimethylsilyl)-beta	PROPN
dti-1318	971	15	-	-	PUNCT
dti-1318	971	16	d	d	NOUN
dti-1318	971	17	-	-	PUNCT
dti-1318	971	18	ribofuranosyl]3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide)thymine	ribofuranosyl]3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide)thymine	PROPN
dti-1318	971	19	(	(	PUNCT
dti-1318	971	20	tsao	tsao	NOUN
dti-1318	971	21	)	)	PUNCT
dti-1318	971	22	derivatives	derivative	NOUN
dti-1318	971	23	at	at	ADP
dti-1318	971	24	the	the	DET
dti-1318	971	25	p51	p51	PROPN
dti-1318	971	26	-	-	PUNCT
dti-1318	971	27	p66	p66	NOUN
dti-1318	971	28	interface	interface	NOUN
dti-1318	971	29	of	of	ADP
dti-1318	971	30	hiv-1	hiv-1	X
dti-1318	971	31	reverse	reverse	ADJ
dti-1318	971	32	transcriptase	transcriptase	NOUN
dti-1318	971	33	.	.	PUNCT
dti-1318	972	1	j.	j.	PROPN
dti-1318	972	2	med	med	PROPN
dti-1318	972	3	.	.	PROPN
dti-1318	972	4	chem	chem	PROPN
dti-1318	972	5	.	.	PUNCT
dti-1318	972	6	,	,	PUNCT
dti-1318	972	7	44:1853–1865	44:1853–1865	NUM
dti-1318	972	8	.	.	PUNCT
dti-1318	973	1	rodriguez	rodriguez	NOUN
dti-1318	973	2	-	-	PUNCT
dti-1318	973	3	rodriguez	rodriguez	PROPN
dti-1318	973	4	,	,	PUNCT
dti-1318	973	5	l.	l.	PROPN
dti-1318	973	6	,	,	PUNCT
dti-1318	973	7	tsuchihashi	tsuchihashi	PROPN
dti-1318	973	8	,	,	PUNCT
dti-1318	973	9	z.	z.	PROPN
dti-1318	973	10	,	,	PUNCT
dti-1318	973	11	fuentes	fuentes	PROPN
dti-1318	973	12	,	,	PUNCT
dti-1318	973	13	g.m	g.m	PROPN
dti-1318	973	14	.	.	PROPN
dti-1318	973	15	,	,	PUNCT
dti-1318	973	16	bambara	bambara	PROPN
dti-1318	973	17	,	,	PUNCT
dti-1318	973	18	r.a	r.a	PROPN
dti-1318	973	19	.	.	PROPN
dti-1318	973	20	and	and	CCONJ
dti-1318	973	21	fay	fay	PROPN
dti-1318	973	22	,	,	PUNCT
dti-1318	973	23	p.j	p.j	PROPN
dti-1318	973	24	.	.	PROPN
dti-1318	973	25	1995	1995	NUM
dti-1318	973	26	.	.	PUNCT
dti-1318	974	1	infl	infl	PROPN
dti-1318	974	2	uence	uence	PROPN
dti-1318	974	3	of	of	ADP
dti-1318	974	4	human	human	ADJ
dti-1318	974	5	immunodefi	immunodefi	PROPN
dti-1318	974	6	ciency	ciency	NOUN
dti-1318	974	7	virus	virus	NOUN
dti-1318	974	8	nucleocapsid	nucleocapsid	ADJ
dti-1318	974	9	protein	protein	NOUN
dti-1318	974	10	on	on	ADP
dti-1318	974	11	synthesis	synthesis	NOUN
dti-1318	974	12	and	and	CCONJ
dti-1318	974	13	strand	strand	NOUN
dti-1318	974	14	transfer	transfer	NOUN
dti-1318	974	15	by	by	ADP
dti-1318	974	16	the	the	DET
dti-1318	974	17	reverse	reverse	ADJ
dti-1318	974	18	transcriptase	transcriptase	NOUN
dti-1318	974	19	in	in	ADP
dti-1318	974	20	vitro	vitro	X
dti-1318	974	21	.	.	PUNCT
dti-1318	975	1	j.	j.	PROPN
dti-1318	975	2	biol	biol	PROPN
dti-1318	975	3	.	.	PUNCT
dti-1318	976	1	chem	chem	PROPN
dti-1318	976	2	.	.	PUNCT
dti-1318	976	3	,	,	PUNCT
dti-1318	976	4	270:15005–15011	270:15005–15011	NUM
dti-1318	976	5	.	.	PUNCT
dti-1318	977	1	rozzelle	rozzelle	NOUN
dti-1318	977	2	,	,	PUNCT
dti-1318	977	3	j.e	j.e	PROPN
dti-1318	977	4	.	.	PROPN
dti-1318	977	5	,	,	PUNCT
dti-1318	977	6	dauber	dauber	PROPN
dti-1318	977	7	,	,	PUNCT
dti-1318	977	8	d.s	d.s	PROPN
dti-1318	977	9	.	.	PROPN
dti-1318	977	10	,	,	PUNCT
dti-1318	977	11	todd	todd	PROPN
dti-1318	977	12	,	,	PUNCT
dti-1318	977	13	s.	s.	PROPN
dti-1318	977	14	,	,	PUNCT
dti-1318	977	15	kelley	kelley	PROPN
dti-1318	977	16	,	,	PUNCT
dti-1318	977	17	r.	r.	PROPN
dti-1318	977	18	and	and	CCONJ
dti-1318	977	19	craik	craik	NOUN
dti-1318	977	20	,	,	PUNCT
dti-1318	977	21	c.s	c.s	PROPN
dti-1318	977	22	.	.	PROPN
dti-1318	977	23	2000	2000	NUM
dti-1318	977	24	.	.	PUNCT
dti-1318	978	1	macromolecular	macromolecular	ADJ
dti-1318	978	2	inhibitors	inhibitor	NOUN
dti-1318	978	3	of	of	ADP
dti-1318	978	4	hiv-1	hiv-1	X
dti-1318	978	5	protease	protease	NOUN
dti-1318	978	6	.	.	PUNCT
dti-1318	979	1	characterization	characterization	NOUN
dti-1318	979	2	of	of	ADP
dti-1318	979	3	designed	design	VERB
dti-1318	979	4	heterodimers	heterodimer	NOUN
dti-1318	979	5	.	.	PUNCT
dti-1318	980	1	j.	j.	PROPN
dti-1318	980	2	biol	biol	PROPN
dti-1318	980	3	.	.	PUNCT
dti-1318	981	1	chem	chem	PROPN
dti-1318	981	2	.	.	PUNCT
dti-1318	982	1	,	,	PUNCT
dti-1318	982	2	275:7080–7086	275:7080–7086	NUM
dti-1318	982	3	.	.	PUNCT
dti-1318	983	1	ruland	ruland	PROPN
dti-1318	983	2	,	,	PUNCT
dti-1318	983	3	j.	j.	PROPN
dti-1318	983	4	,	,	PUNCT
dti-1318	983	5	sirard	sirard	PROPN
dti-1318	983	6	,	,	PUNCT
dti-1318	983	7	c.	c.	PROPN
dti-1318	983	8	,	,	PUNCT
dti-1318	983	9	elia	elia	PROPN
dti-1318	983	10	,	,	PUNCT
dti-1318	983	11	a.	a.	PROPN
dti-1318	983	12	,	,	PUNCT
dti-1318	983	13	macpherson	macpherson	PROPN
dti-1318	983	14	,	,	PUNCT
dti-1318	983	15	d.	d.	PROPN
dti-1318	983	16	,	,	PUNCT
dti-1318	983	17	wakeham	wakeham	PROPN
dti-1318	983	18	,	,	PUNCT
dti-1318	983	19	a.	a.	PROPN
dti-1318	983	20	,	,	PUNCT
dti-1318	983	21	li	li	PROPN
dti-1318	983	22	,	,	PUNCT
dti-1318	983	23	l.	l.	PROPN
dti-1318	983	24	,	,	PUNCT
dti-1318	983	25	de	de	PROPN
dti-1318	983	26	la	la	X
dti-1318	983	27	pompa	pompa	PROPN
dti-1318	983	28	,	,	PUNCT
dti-1318	983	29	j.l	j.l	PROPN
dti-1318	983	30	.	.	PROPN
dti-1318	983	31	,	,	PUNCT
dti-1318	983	32	cohen	cohen	PROPN
dti-1318	983	33	,	,	PUNCT
dti-1318	983	34	s.n	s.n	PROPN
dti-1318	983	35	.	.	PROPN
dti-1318	983	36	and	and	CCONJ
dti-1318	983	37	mak	mak	PROPN
dti-1318	983	38	,	,	PUNCT
dti-1318	983	39	t.w	t.w	PROPN
dti-1318	983	40	.	.	PROPN
dti-1318	983	41	2001	2001	NUM
dti-1318	983	42	.	.	PUNCT
dti-1318	984	1	p53	p53	NOUN
dti-1318	984	2	accumulation	accumulation	NOUN
dti-1318	984	3	,	,	PUNCT
dti-1318	984	4	defective	defective	ADJ
dti-1318	984	5	cell	cell	NOUN
dti-1318	984	6	proliferation	proliferation	NOUN
dti-1318	984	7	,	,	PUNCT
dti-1318	984	8	and	and	CCONJ
dti-1318	984	9	early	early	ADJ
dti-1318	984	10	embryonic	embryonic	ADJ
dti-1318	984	11	lethality	lethality	NOUN
dti-1318	984	12	in	in	ADP
dti-1318	984	13	mice	mouse	NOUN
dti-1318	984	14	lacking	lack	VERB
dti-1318	984	15	tsg101	tsg101	PROPN
dti-1318	984	16	.	.	PUNCT
dti-1318	985	1	proc	proc	PROPN
dti-1318	985	2	.	.	PUNCT
dti-1318	986	1	natl	natl	PROPN
dti-1318	986	2	.	.	PUNCT
dti-1318	987	1	acad	acad	PROPN
dti-1318	987	2	.	.	PUNCT
dti-1318	988	1	sci	sci	PROPN
dti-1318	988	2	.	.	PUNCT
dti-1318	988	3	u.s.a	u.s.a	PROPN
dti-1318	988	4	.	.	PROPN
dti-1318	988	5	,	,	PUNCT
dti-1318	988	6	98:1859–1864	98:1859–1864	NUM
dti-1318	988	7	.	.	PUNCT
dti-1318	989	1	saad	saad	PROPN
dti-1318	989	2	,	,	PUNCT
dti-1318	989	3	j.s	j.s	PROPN
dti-1318	989	4	.	.	PROPN
dti-1318	989	5	,	,	PUNCT
dti-1318	989	6	miller	miller	PROPN
dti-1318	989	7	,	,	PUNCT
dti-1318	989	8	j.	j.	PROPN
dti-1318	989	9	,	,	PUNCT
dti-1318	989	10	tai	tai	PROPN
dti-1318	989	11	,	,	PUNCT
dti-1318	989	12	j.	j.	PROPN
dti-1318	989	13	,	,	PUNCT
dti-1318	989	14	kim	kim	PROPN
dti-1318	989	15	,	,	PUNCT
dti-1318	989	16	a.	a.	PROPN
dti-1318	989	17	,	,	PUNCT
dti-1318	989	18	ghanam	ghanam	PROPN
dti-1318	989	19	,	,	PUNCT
dti-1318	989	20	r.h	r.h	PROPN
dti-1318	989	21	.	.	PROPN
dti-1318	989	22	and	and	CCONJ
dti-1318	989	23	summers	summer	NOUN
dti-1318	989	24	,	,	PUNCT
dti-1318	989	25	m.f	m.f	PROPN
dti-1318	989	26	.	.	PROPN
dti-1318	989	27	2006	2006	NUM
dti-1318	989	28	.	.	PUNCT
dti-1318	990	1	structural	structural	ADJ
dti-1318	990	2	basis	basis	NOUN
dti-1318	990	3	for	for	ADP
dti-1318	990	4	targeting	target	VERB
dti-1318	990	5	hiv-1	hiv-1	X
dti-1318	990	6	gag	gag	NOUN
dti-1318	990	7	proteins	protein	NOUN
dti-1318	990	8	to	to	ADP
dti-1318	990	9	the	the	DET
dti-1318	990	10	plasma	plasma	NOUN
dti-1318	990	11	membrane	membrane	NOUN
dti-1318	990	12	for	for	ADP
dti-1318	990	13	virus	virus	NOUN
dti-1318	990	14	assembly	assembly	NOUN
dti-1318	990	15	.	.	PUNCT
dti-1318	991	1	proc	proc	PROPN
dti-1318	991	2	.	.	PUNCT
dti-1318	992	1	natl	natl	PROPN
dti-1318	992	2	.	.	PUNCT
dti-1318	993	1	acad	acad	PROPN
dti-1318	993	2	.	.	PUNCT
dti-1318	994	1	sci	sci	PROPN
dti-1318	994	2	.	.	PUNCT
dti-1318	994	3	u.s.a	u.s.a	PROPN
dti-1318	994	4	.	.	PROPN
dti-1318	994	5	,	,	PUNCT
dti-1318	994	6	103:11364–11369	103:11364–11369	PROPN
dti-1318	994	7	.	.	PUNCT
dti-1318	994	8	sakalian	sakalian	PROPN
dti-1318	994	9	,	,	PUNCT
dti-1318	994	10	m.	m.	NOUN
dti-1318	994	11	,	,	PUNCT
dti-1318	994	12	mcmurtrey	mcmurtrey	PROPN
dti-1318	994	13	,	,	PUNCT
dti-1318	994	14	c.p	c.p	PROPN
dti-1318	994	15	.	.	PROPN
dti-1318	994	16	,	,	PUNCT
dti-1318	994	17	deeg	deeg	PROPN
dti-1318	994	18	,	,	PUNCT
dti-1318	994	19	f.j	f.j	PROPN
dti-1318	994	20	.	.	PROPN
dti-1318	994	21	,	,	PUNCT
dti-1318	994	22	maloy	maloy	PROPN
dti-1318	994	23	,	,	PUNCT
dti-1318	994	24	c.w	c.w	PROPN
dti-1318	994	25	.	.	PROPN
dti-1318	994	26	,	,	PUNCT
dti-1318	994	27	li	li	PROPN
dti-1318	994	28	,	,	PUNCT
dti-1318	994	29	f.	f.	PROPN
dti-1318	994	30	,	,	PUNCT
dti-1318	994	31	wild	wild	PROPN
dti-1318	994	32	,	,	PUNCT
dti-1318	994	33	c.t	c.t	PROPN
dti-1318	994	34	.	.	PROPN
dti-1318	994	35	and	and	CCONJ
dti-1318	994	36	salzwedel	salzwedel	PROPN
dti-1318	994	37	,	,	PUNCT
dti-1318	994	38	k.	k.	PROPN
dti-1318	994	39	2006	2006	NUM
dti-1318	994	40	.	.	PUNCT
dti-1318	995	1	3	3	NUM
dti-1318	995	2	-	-	PUNCT
dti-1318	995	3	o-(3′,3′-dimethysuccinyl	o-(3′,3′-dimethysuccinyl	ADJ
dti-1318	995	4	)	)	PUNCT
dti-1318	995	5	betulinic	betulinic	ADJ
dti-1318	995	6	acid	acid	PROPN
dti-1318	995	7	inhibits	inhibit	VERB
dti-1318	995	8	maturation	maturation	NOUN
dti-1318	995	9	of	of	ADP
dti-1318	995	10	the	the	DET
dti-1318	995	11	human	human	ADJ
dti-1318	995	12	immunodefi	immunodefi	PROPN
dti-1318	995	13	ciency	ciency	NOUN
dti-1318	995	14	virus	virus	NOUN
dti-1318	995	15	type	type	NOUN
dti-1318	995	16	1	1	NUM
dti-1318	995	17	gag	gag	NOUN
dti-1318	995	18	precursor	precursor	NOUN
dti-1318	995	19	assembled	assemble	VERB
dti-1318	995	20	in	in	ADP
dti-1318	995	21	vitro	vitro	X
dti-1318	995	22	.	.	PUNCT
dti-1318	996	1	j.	j.	PROPN
dti-1318	996	2	virol	virol	PROPN
dti-1318	996	3	.	.	PUNCT
dti-1318	996	4	,	,	PUNCT
dti-1318	996	5	80:5716–5722	80:5716–5722	PROPN
dti-1318	996	6	.	.	PUNCT
dti-1318	996	7	schito	schito	PROPN
dti-1318	996	8	,	,	PUNCT
dti-1318	996	9	m.l	m.l	PROPN
dti-1318	996	10	.	.	PROPN
dti-1318	996	11	,	,	PUNCT
dti-1318	996	12	goel	goel	PROPN
dti-1318	996	13	,	,	PUNCT
dti-1318	996	14	a.	a.	NOUN
dti-1318	996	15	,	,	PUNCT
dti-1318	996	16	song	song	NOUN
dti-1318	996	17	,	,	PUNCT
dti-1318	996	18	y.	y.	PROPN
dti-1318	996	19	,	,	PUNCT
dti-1318	996	20	inman	inman	PROPN
dti-1318	996	21	,	,	PUNCT
dti-1318	996	22	j.k	j.k	PROPN
dti-1318	996	23	.	.	PROPN
dti-1318	996	24	,	,	PUNCT
dti-1318	996	25	fattah	fattah	PROPN
dti-1318	996	26	,	,	PUNCT
dti-1318	996	27	r.j	r.j	PROPN
dti-1318	996	28	.	.	PROPN
dti-1318	996	29	,	,	PUNCT
dti-1318	996	30	rice	rice	PROPN
dti-1318	996	31	,	,	PUNCT
dti-1318	996	32	w.g	w.g	PROPN
dti-1318	996	33	.	.	PROPN
dti-1318	996	34	,	,	PUNCT
dti-1318	996	35	turpin	turpin	PROPN
dti-1318	996	36	,	,	PUNCT
dti-1318	996	37	j.a	j.a	PROPN
dti-1318	996	38	.	.	PROPN
dti-1318	996	39	,	,	PUNCT
dti-1318	996	40	sher	sher	PROPN
dti-1318	996	41	,	,	PUNCT
dti-1318	996	42	a.	a.	NOUN
dti-1318	996	43	and	and	CCONJ
dti-1318	996	44	appella	appella	PROPN
dti-1318	996	45	,	,	PUNCT
dti-1318	996	46	e.	e.	PROPN
dti-1318	996	47	2003	2003	NUM
dti-1318	996	48	.	.	PUNCT
dti-1318	997	1	in	in	ADP
dti-1318	997	2	vivo	vivo	ADJ
dti-1318	997	3	antiviral	antiviral	ADJ
dti-1318	997	4	activity	activity	NOUN
dti-1318	997	5	of	of	ADP
dti-1318	997	6	novel	novel	ADJ
dti-1318	997	7	human	human	ADJ
dti-1318	997	8	immunodefi	immunodefi	PROPN
dti-1318	997	9	ciency	ciency	NOUN
dti-1318	997	10	virus	virus	NOUN
dti-1318	997	11	type	type	NOUN
dti-1318	997	12	1	1	NUM
dti-1318	997	13	nucleocapsid	nucleocapsid	ADJ
dti-1318	997	14	p7	p7	ADJ
dti-1318	997	15	zinc	zinc	NOUN
dti-1318	997	16	fi	fi	NOUN
dti-1318	997	17	nger	nger	ADJ
dti-1318	997	18	inhibitors	inhibitor	NOUN
dti-1318	997	19	in	in	ADP
dti-1318	997	20	a	a	DET
dti-1318	997	21	transgenic	transgenic	NOUN
dti-1318	997	22	murine	murine	ADJ
dti-1318	997	23	model	model	NOUN
dti-1318	997	24	.	.	PUNCT
dti-1318	998	1	aids	aids	PROPN
dti-1318	998	2	res	re	NOUN
dti-1318	998	3	.	.	PUNCT
dti-1318	999	1	hum	hum	PROPN
dti-1318	999	2	.	.	PUNCT
dti-1318	1000	1	retroviruses	retrovirus	NOUN
dti-1318	1000	2	,	,	PUNCT
dti-1318	1000	3	19:91–101	19:91–101	NUM
dti-1318	1000	4	.	.	PUNCT
dti-1318	1001	1	schito	schito	PROPN
dti-1318	1001	2	,	,	PUNCT
dti-1318	1001	3	m.l	m.l	PROPN
dti-1318	1001	4	.	.	PROPN
dti-1318	1001	5	,	,	PUNCT
dti-1318	1001	6	soloff	soloff	PROPN
dti-1318	1001	7	,	,	PUNCT
dti-1318	1001	8	a.c	a.c	PROPN
dti-1318	1001	9	.	.	PROPN
dti-1318	1001	10	,	,	PUNCT
dti-1318	1001	11	slovitz	slovitz	PROPN
dti-1318	1001	12	,	,	PUNCT
dti-1318	1001	13	d.	d.	PROPN
dti-1318	1001	14	,	,	PUNCT
dti-1318	1001	15	trichel	trichel	PROPN
dti-1318	1001	16	,	,	PUNCT
dti-1318	1001	17	a.	a.	NOUN
dti-1318	1001	18	,	,	PUNCT
dti-1318	1001	19	inman	inman	PROPN
dti-1318	1001	20	,	,	PUNCT
dti-1318	1001	21	j.k	j.k	PROPN
dti-1318	1001	22	.	.	PROPN
dti-1318	1001	23	,	,	PUNCT
dti-1318	1001	24	appella	appella	PROPN
dti-1318	1001	25	,	,	PUNCT
dti-1318	1001	26	e.	e.	PROPN
dti-1318	1001	27	,	,	PUNCT
dti-1318	1001	28	turpin	turpin	PROPN
dti-1318	1001	29	,	,	PUNCT
dti-1318	1001	30	j.a	j.a	PROPN
dti-1318	1001	31	.	.	PROPN
dti-1318	1001	32	and	and	CCONJ
dti-1318	1001	33	barratt	barratt	PROPN
dti-1318	1001	34	-	-	PUNCT
dti-1318	1001	35	boyes	boyes	PROPN
dti-1318	1001	36	,	,	PUNCT
dti-1318	1001	37	s.m	s.m	PROPN
dti-1318	1001	38	.	.	PROPN
dti-1318	1001	39	2006	2006	NUM
dti-1318	1001	40	.	.	PUNCT
dti-1318	1002	1	preclinical	preclinical	ADJ
dti-1318	1002	2	evaluation	evaluation	NOUN
dti-1318	1002	3	of	of	ADP
dti-1318	1002	4	a	a	DET
dti-1318	1002	5	zinc	zinc	NOUN
dti-1318	1002	6	fi	fi	NOUN
dti-1318	1002	7	nger	nger	ADJ
dti-1318	1002	8	inhibitor	inhibitor	NOUN
dti-1318	1002	9	targeting	target	VERB
dti-1318	1002	10	lentivirus	lentivirus	NOUN
dti-1318	1002	11	nucleocapsid	nucleocapsid	ADJ
dti-1318	1002	12	protein	protein	NOUN
dti-1318	1002	13	in	in	ADP
dti-1318	1002	14	siv	siv	NOUN
dti-1318	1002	15	-	-	PUNCT
dti-1318	1002	16	infected	infect	VERB
dti-1318	1002	17	monkeys	monkey	NOUN
dti-1318	1002	18	.	.	PUNCT
dti-1318	1003	1	curr	curr	PROPN
dti-1318	1003	2	.	.	PUNCT
dti-1318	1004	1	hiv	hiv	PROPN
dti-1318	1004	2	res	res	PROPN
dti-1318	1004	3	.	.	PROPN
dti-1318	1004	4	,	,	PUNCT
dti-1318	1004	5	4:379–386	4:379–386	NUM
dti-1318	1004	6	.	.	PUNCT
dti-1318	1005	1	schramm	schramm	PROPN
dti-1318	1005	2	,	,	PUNCT
dti-1318	1005	3	h.j	h.j	PROPN
dti-1318	1005	4	.	.	PROPN
dti-1318	1005	5	,	,	PUNCT
dti-1318	1005	6	boetzel	boetzel	PROPN
dti-1318	1005	7	,	,	PUNCT
dti-1318	1005	8	j.	j.	PROPN
dti-1318	1005	9	,	,	PUNCT
dti-1318	1005	10	buttner	buttner	PROPN
dti-1318	1005	11	,	,	PUNCT
dti-1318	1005	12	j.	j.	PROPN
dti-1318	1005	13	,	,	PUNCT
dti-1318	1005	14	fritsche	fritsche	PROPN
dti-1318	1005	15	,	,	PUNCT
dti-1318	1005	16	e.	e.	PROPN
dti-1318	1005	17	,	,	PUNCT
dti-1318	1005	18	gohring	gohring	PROPN
dti-1318	1005	19	,	,	PUNCT
dti-1318	1005	20	w.	w.	PROPN
dti-1318	1005	21	,	,	PUNCT
dti-1318	1005	22	jaeger	jaeger	PROPN
dti-1318	1005	23	,	,	PUNCT
dti-1318	1005	24	e.	e.	PROPN
dti-1318	1005	25	,	,	PUNCT
dti-1318	1005	26	konig	konig	PROPN
dti-1318	1005	27	,	,	PUNCT
dti-1318	1005	28	s.	s.	PROPN
dti-1318	1005	29	,	,	PUNCT
dti-1318	1005	30	thumfart	thumfart	NOUN
dti-1318	1005	31	,	,	PUNCT
dti-1318	1005	32	o.	o.	PROPN
dti-1318	1005	33	,	,	PUNCT
dti-1318	1005	34	wenger	wenger	PROPN
dti-1318	1005	35	,	,	PUNCT
dti-1318	1005	36	t.	t.	PROPN
dti-1318	1005	37	,	,	PUNCT
dti-1318	1005	38	nagel	nagel	PROPN
dti-1318	1005	39	,	,	PUNCT
dti-1318	1005	40	n.e	n.e	PROPN
dti-1318	1005	41	.	.	PROPN
dti-1318	1005	42	and	and	CCONJ
dti-1318	1005	43	schramm	schramm	PROPN
dti-1318	1005	44	,	,	PUNCT
dti-1318	1005	45	w.	w.	PROPN
dti-1318	1005	46	1996	1996	NUM
dti-1318	1005	47	.	.	PUNCT
dti-1318	1006	1	the	the	DET
dti-1318	1006	2	inhibition	inhibition	NOUN
dti-1318	1006	3	of	of	ADP
dti-1318	1006	4	human	human	ADJ
dti-1318	1006	5	immunodefi	immunodefi	NOUN
dti-1318	1006	6	ciency	ciency	NOUN
dti-1318	1006	7	virus	virus	NOUN
dti-1318	1006	8	proteases	protease	NOUN
dti-1318	1006	9	by	by	ADP
dti-1318	1006	10	‘	'	PUNCT
dti-1318	1006	11	interface	interface	NOUN
dti-1318	1006	12	peptides	peptide	NOUN
dti-1318	1006	13	’	'	PUNCT
dti-1318	1006	14	.	.	PUNCT
dti-1318	1007	1	antiviral	antiviral	ADJ
dti-1318	1007	2	res	re	NOUN
dti-1318	1007	3	.	.	PUNCT
dti-1318	1007	4	,	,	PUNCT
dti-1318	1007	5	30	30	NUM
dti-1318	1007	6	:	:	SYM
dti-1318	1007	7	155	155	NUM
dti-1318	1007	8	-	-	SYM
dti-1318	1007	9	170	170	NUM
dti-1318	1007	10	.	.	PUNCT
dti-1318	1008	1	schramm	schramm	PROPN
dti-1318	1008	2	,	,	PUNCT
dti-1318	1008	3	h.j	h.j	PROPN
dti-1318	1008	4	.	.	PROPN
dti-1318	1008	5	,	,	PUNCT
dti-1318	1008	6	de	de	X
dti-1318	1008	7	rosny	rosny	ADJ
dti-1318	1008	8	,	,	PUNCT
dti-1318	1008	9	e.	e.	PROPN
dti-1318	1008	10	,	,	PUNCT
dti-1318	1008	11	reboud	reboud	PROPN
dti-1318	1008	12	-	-	PUNCT
dti-1318	1008	13	ravaux	ravaux	NOUN
dti-1318	1008	14	,	,	PUNCT
dti-1318	1008	15	m.	m.	NOUN
dti-1318	1008	16	,	,	PUNCT
dti-1318	1008	17	buttner	buttner	PROPN
dti-1318	1008	18	,	,	PUNCT
dti-1318	1008	19	j.	j.	PROPN
dti-1318	1008	20	,	,	PUNCT
dti-1318	1008	21	dick	dick	PROPN
dti-1318	1008	22	,	,	PUNCT
dti-1318	1008	23	a.	a.	NOUN
dti-1318	1008	24	and	and	CCONJ
dti-1318	1008	25	schramm	schramm	PROPN
dti-1318	1008	26	,	,	PUNCT
dti-1318	1008	27	w.	w.	PROPN
dti-1318	1008	28	1999	1999	NUM
dti-1318	1008	29	.	.	PUNCT
dti-1318	1009	1	lipopeptides	lipopeptide	NOUN
dti-1318	1009	2	as	as	ADP
dti-1318	1009	3	dimerization	dimerization	NOUN
dti-1318	1009	4	inhibitors	inhibitor	NOUN
dti-1318	1009	5	of	of	ADP
dti-1318	1009	6	hiv-1	hiv-1	X
dti-1318	1009	7	protease	protease	NOUN
dti-1318	1009	8	.	.	PUNCT
dti-1318	1010	1	biol	biol	PROPN
dti-1318	1010	2	.	.	PUNCT
dti-1318	1011	1	chem	chem	PROPN
dti-1318	1011	2	.	.	PUNCT
dti-1318	1011	3	,	,	PUNCT
dti-1318	1011	4	380:593–596	380:593–596	NUM
dti-1318	1011	5	.	.	PUNCT
dti-1318	1012	1	schramm	schramm	PROPN
dti-1318	1012	2	,	,	PUNCT
dti-1318	1012	3	h.j	h.j	PROPN
dti-1318	1012	4	.	.	PROPN
dti-1318	1012	5	,	,	PUNCT
dti-1318	1012	6	nakashima	nakashima	PROPN
dti-1318	1012	7	,	,	PUNCT
dti-1318	1012	8	h.	h.	PROPN
dti-1318	1012	9	,	,	PUNCT
dti-1318	1012	10	schramm	schramm	PROPN
dti-1318	1012	11	,	,	PUNCT
dti-1318	1012	12	w.	w.	PROPN
dti-1318	1012	13	,	,	PUNCT
dti-1318	1012	14	wakayama	wakayama	NOUN
dti-1318	1012	15	,	,	PUNCT
dti-1318	1012	16	h.	h.	PROPN
dti-1318	1012	17	and	and	CCONJ
dti-1318	1012	18	yamamoto	yamamoto	PROPN
dti-1318	1012	19	,	,	PUNCT
dti-1318	1012	20	n.	n.	PROPN
dti-1318	1012	21	1991	1991	NUM
dti-1318	1012	22	.	.	PUNCT
dti-1318	1013	1	hiv-1	hiv-1	ADJ
dti-1318	1013	2	reproduction	reproduction	NOUN
dti-1318	1013	3	is	be	AUX
dti-1318	1013	4	inhibited	inhibit	VERB
dti-1318	1013	5	by	by	ADP
dti-1318	1013	6	peptides	peptide	NOUN
dti-1318	1013	7	derived	derive	VERB
dti-1318	1013	8	from	from	ADP
dti-1318	1013	9	the	the	DET
dti-1318	1013	10	nand	nand	NOUN
dti-1318	1013	11	c	c	NOUN
dti-1318	1013	12	-	-	PUNCT
dti-1318	1013	13	termini	termini	NOUN
dti-1318	1013	14	of	of	ADP
dti-1318	1013	15	hiv-1	hiv-1	X
dti-1318	1013	16	protease	protease	NOUN
dti-1318	1013	17	.	.	PUNCT
dti-1318	1014	1	biochem	biochem	PROPN
dti-1318	1014	2	.	.	PUNCT
dti-1318	1015	1	biophys	biophy	NOUN
dti-1318	1015	2	.	.	PUNCT
dti-1318	1016	1	res	re	NOUN
dti-1318	1016	2	.	.	PUNCT
dti-1318	1017	1	commun	commun	PROPN
dti-1318	1017	2	.	.	PROPN
dti-1318	1017	3	,	,	PUNCT
dti-1318	1017	4	179:847–851	179:847–851	NUM
dti-1318	1017	5	.	.	PUNCT
dti-1318	1018	1	schubert	schubert	PROPN
dti-1318	1018	2	,	,	PUNCT
dti-1318	1018	3	u.	u.	PROPN
dti-1318	1018	4	,	,	PUNCT
dti-1318	1018	5	ferrer	ferrer	PROPN
dti-1318	1018	6	-	-	PROPN
dti-1318	1018	7	montiel	montiel	PROPN
dti-1318	1018	8	,	,	PUNCT
dti-1318	1018	9	a.v	a.v	PROPN
dti-1318	1018	10	.	.	PROPN
dti-1318	1018	11	,	,	PUNCT
dti-1318	1018	12	oblatt	oblatt	ADJ
dti-1318	1018	13	-	-	PUNCT
dti-1318	1018	14	montal	montal	ADJ
dti-1318	1018	15	,	,	PUNCT
dti-1318	1018	16	m.	m.	NOUN
dti-1318	1018	17	,	,	PUNCT
dti-1318	1018	18	henklein	henklein	PROPN
dti-1318	1018	19	,	,	PUNCT
dti-1318	1018	20	p.	p.	NOUN
dti-1318	1018	21	,	,	PUNCT
dti-1318	1018	22	strebel	strebel	NOUN
dti-1318	1018	23	,	,	PUNCT
dti-1318	1018	24	k.	k.	PROPN
dti-1318	1018	25	and	and	CCONJ
dti-1318	1018	26	montal	montal	PROPN
dti-1318	1018	27	,	,	PUNCT
dti-1318	1018	28	m.	m.	NOUN
dti-1318	1018	29	1996a	1996a	NUM
dti-1318	1018	30	.	.	PUNCT
dti-1318	1019	1	identifi	identifi	PROPN
dti-1318	1019	2	cation	cation	NOUN
dti-1318	1019	3	of	of	ADP
dti-1318	1019	4	an	an	DET
dti-1318	1019	5	ion	ion	NOUN
dti-1318	1019	6	channel	channel	NOUN
dti-1318	1019	7	activity	activity	NOUN
dti-1318	1019	8	of	of	ADP
dti-1318	1019	9	the	the	DET
dti-1318	1019	10	vpu	vpu	NOUN
dti-1318	1019	11	transmembrane	transmembrane	ADJ
dti-1318	1019	12	domain	domain	NOUN
dti-1318	1019	13	and	and	CCONJ
dti-1318	1019	14	its	its	PRON
dti-1318	1019	15	involvement	involvement	NOUN
dti-1318	1019	16	in	in	ADP
dti-1318	1019	17	the	the	DET
dti-1318	1019	18	regulation	regulation	NOUN
dti-1318	1019	19	of	of	ADP
dti-1318	1019	20	virus	virus	NOUN
dti-1318	1019	21	release	release	NOUN
dti-1318	1019	22	from	from	ADP
dti-1318	1019	23	hiv-1	hiv-1	ADV
dti-1318	1019	24	-	-	PUNCT
dti-1318	1019	25	infected	infect	VERB
dti-1318	1019	26	cells	cell	NOUN
dti-1318	1019	27	.	.	PUNCT
dti-1318	1020	1	febs	febs	PROPN
dti-1318	1020	2	lett	lett	PROPN
dti-1318	1020	3	,	,	PUNCT
dti-1318	1020	4	398:12–18	398:12–18	NUM
dti-1318	1020	5	.	.	PUNCT
dti-1318	1020	6	schubert	schubert	PROPN
dti-1318	1020	7	,	,	PUNCT
dti-1318	1020	8	u.	u.	PROPN
dti-1318	1020	9	,	,	PUNCT
dti-1318	1020	10	ott	ott	PROPN
dti-1318	1020	11	,	,	PUNCT
dti-1318	1020	12	d.e	d.e	PROPN
dti-1318	1020	13	.	.	PROPN
dti-1318	1020	14	,	,	PUNCT
dti-1318	1020	15	chertova	chertova	PROPN
dti-1318	1020	16	,	,	PUNCT
dti-1318	1020	17	e.n	e.n	PROPN
dti-1318	1020	18	.	.	PROPN
dti-1318	1020	19	,	,	PUNCT
dti-1318	1020	20	welker	welker	PROPN
dti-1318	1020	21	,	,	PUNCT
dti-1318	1020	22	r.	r.	PROPN
dti-1318	1020	23	,	,	PUNCT
dti-1318	1020	24	tessmer	tessmer	NOUN
dti-1318	1020	25	,	,	PUNCT
dti-1318	1020	26	u.	u.	PROPN
dti-1318	1020	27	,	,	PUNCT
dti-1318	1020	28	princiotta	princiotta	NOUN
dti-1318	1020	29	,	,	PUNCT
dti-1318	1020	30	m.f	m.f	PROPN
dti-1318	1020	31	.	.	PROPN
dti-1318	1020	32	,	,	PUNCT
dti-1318	1020	33	bennink	bennink	NOUN
dti-1318	1020	34	,	,	PUNCT
dti-1318	1020	35	j.r	j.r	PROPN
dti-1318	1020	36	.	.	PROPN
dti-1318	1020	37	,	,	PUNCT
dti-1318	1020	38	krausslich	krausslich	PROPN
dti-1318	1020	39	,	,	PUNCT
dti-1318	1020	40	h.g	h.g	X
dti-1318	1020	41	.	.	PROPN
dti-1318	1020	42	and	and	CCONJ
dti-1318	1020	43	yewdell	yewdell	PROPN
dti-1318	1020	44	,	,	PUNCT
dti-1318	1020	45	j.w	j.w	PROPN
dti-1318	1020	46	.	.	PROPN
dti-1318	1020	47	2000	2000	NUM
dti-1318	1020	48	.	.	PUNCT
dti-1318	1021	1	proteasome	proteasome	NOUN
dti-1318	1021	2	inhibition	inhibition	NOUN
dti-1318	1021	3	interferes	interfere	VERB
dti-1318	1021	4	with	with	ADP
dti-1318	1021	5	gag	gag	NOUN
dti-1318	1021	6	polyprotein	polyprotein	ADJ
dti-1318	1021	7	processing	processing	NOUN
dti-1318	1021	8	,	,	PUNCT
dti-1318	1021	9	release	release	NOUN
dti-1318	1021	10	,	,	PUNCT
dti-1318	1021	11	and	and	CCONJ
dti-1318	1021	12	maturation	maturation	NOUN
dti-1318	1021	13	of	of	ADP
dti-1318	1021	14	hiv-1	hiv-1	ADJ
dti-1318	1021	15	and	and	CCONJ
dti-1318	1021	16	hiv-2	hiv-2	ADV
dti-1318	1021	17	.	.	PUNCT
dti-1318	1022	1	proc	proc	NOUN
dti-1318	1022	2	.	.	PUNCT
dti-1318	1023	1	natl	natl	PROPN
dti-1318	1023	2	.	.	PUNCT
dti-1318	1024	1	acad	acad	PROPN
dti-1318	1024	2	.	.	PUNCT
dti-1318	1025	1	sci	sci	PROPN
dti-1318	1025	2	.	.	PUNCT
dti-1318	1025	3	u.s.a	u.s.a	PROPN
dti-1318	1025	4	.	.	PROPN
dti-1318	1025	5	,	,	PUNCT
dti-1318	1025	6	97:13057–13062	97:13057–13062	NUM
dti-1318	1025	7	.	.	PUNCT
dti-1318	1025	8	schwartz	schwartz	PROPN
dti-1318	1025	9	,	,	PUNCT
dti-1318	1025	10	o.	o.	PROPN
dti-1318	1025	11	,	,	PUNCT
dti-1318	1025	12	marechal	marechal	PROPN
dti-1318	1025	13	,	,	PUNCT
dti-1318	1025	14	v.	v.	PROPN
dti-1318	1025	15	,	,	PUNCT
dti-1318	1025	16	friguet	friguet	PROPN
dti-1318	1025	17	,	,	PUNCT
dti-1318	1025	18	b.	b.	PROPN
dti-1318	1025	19	,	,	PUNCT
dti-1318	1025	20	arenzana	arenzana	NOUN
dti-1318	1025	21	-	-	PUNCT
dti-1318	1025	22	seisdedos	seisdedos	PROPN
dti-1318	1025	23	,	,	PUNCT
dti-1318	1025	24	f.	f.	PROPN
dti-1318	1025	25	and	and	CCONJ
dti-1318	1025	26	heard	hear	VERB
dti-1318	1025	27	,	,	PUNCT
dti-1318	1025	28	j.m	j.m	PROPN
dti-1318	1025	29	.	.	PROPN
dti-1318	1025	30	1998	1998	NUM
dti-1318	1025	31	.	.	PUNCT
dti-1318	1026	1	antiviral	antiviral	ADJ
dti-1318	1026	2	activity	activity	NOUN
dti-1318	1026	3	of	of	ADP
dti-1318	1026	4	the	the	DET
dti-1318	1026	5	proteasome	proteasome	NOUN
dti-1318	1026	6	on	on	ADP
dti-1318	1026	7	incoming	incoming	ADJ
dti-1318	1026	8	human	human	ADJ
dti-1318	1026	9	immunodefi	immunodefi	PROPN
dti-1318	1026	10	ciency	ciency	NOUN
dti-1318	1026	11	virus	virus	NOUN
dti-1318	1026	12	type	type	NOUN
dti-1318	1026	13	1	1	NUM
dti-1318	1026	14	.	.	PUNCT
dti-1318	1026	15	j.	j.	PROPN
dti-1318	1026	16	virol	virol	PROPN
dti-1318	1026	17	.	.	PUNCT
dti-1318	1026	18	,	,	PUNCT
dti-1318	1026	19	72	72	NUM
dti-1318	1026	20	:	:	PUNCT
dti-1318	1026	21	3845–3850	3845–3850	NUM
dti-1318	1026	22	.	.	PUNCT
dti-1318	1027	1	serio	serio	PROPN
dti-1318	1027	2	,	,	PUNCT
dti-1318	1027	3	d.	d.	PROPN
dti-1318	1027	4	,	,	PUNCT
dti-1318	1027	5	singh	singh	PROPN
dti-1318	1027	6	,	,	PUNCT
dti-1318	1027	7	s.p	s.p	PROPN
dti-1318	1027	8	.	.	PROPN
dti-1318	1027	9	,	,	PUNCT
dti-1318	1027	10	cartas	carta	NOUN
dti-1318	1027	11	,	,	PUNCT
dti-1318	1027	12	m.a	m.a	PROPN
dti-1318	1027	13	.	.	PROPN
dti-1318	1027	14	,	,	PUNCT
dti-1318	1027	15	weber	weber	PROPN
dti-1318	1027	16	,	,	PUNCT
dti-1318	1027	17	i.t	i.t	PROPN
dti-1318	1027	18	.	.	PROPN
dti-1318	1027	19	,	,	PUNCT
dti-1318	1027	20	harrison	harrison	PROPN
dti-1318	1027	21	,	,	PUNCT
dti-1318	1027	22	r.w	r.w	PROPN
dti-1318	1027	23	.	.	PROPN
dti-1318	1027	24	,	,	PUNCT
dti-1318	1027	25	louis	louis	PROPN
dti-1318	1027	26	,	,	PUNCT
dti-1318	1027	27	j.m	j.m	PROPN
dti-1318	1027	28	.	.	PROPN
dti-1318	1027	29	and	and	CCONJ
dti-1318	1027	30	srinivasan	srinivasan	NOUN
dti-1318	1027	31	,	,	PUNCT
dti-1318	1027	32	a.	a.	NOUN
dti-1318	1027	33	2000	2000	NUM
dti-1318	1027	34	.	.	PUNCT
dti-1318	1028	1	antiviral	antiviral	ADJ
dti-1318	1028	2	agent	agent	NOUN
dti-1318	1028	3	based	base	VERB
dti-1318	1028	4	on	on	ADP
dti-1318	1028	5	the	the	DET
dti-1318	1028	6	non	non	ADJ
dti-1318	1028	7	-	-	ADJ
dti-1318	1028	8	structural	structural	ADJ
dti-1318	1028	9	protein	protein	NOUN
dti-1318	1028	10	targeting	target	VERB
dti-1318	1028	11	the	the	DET
dti-1318	1028	12	maturation	maturation	NOUN
dti-1318	1028	13	process	process	NOUN
dti-1318	1028	14	of	of	ADP
dti-1318	1028	15	hiv-1	hiv-1	ADJ
dti-1318	1028	16	:	:	PUNCT
dti-1318	1028	17	expression	expression	NOUN
dti-1318	1028	18	and	and	CCONJ
dti-1318	1028	19	susceptibility	susceptibility	NOUN
dti-1318	1028	20	of	of	ADP
dti-1318	1028	21	chimeric	chimeric	ADJ
dti-1318	1028	22	vpr	vpr	NOUN
dti-1318	1028	23	as	as	ADP
dti-1318	1028	24	a	a	DET
dti-1318	1028	25	substrate	substrate	NOUN
dti-1318	1028	26	for	for	ADP
dti-1318	1028	27	cleavage	cleavage	NOUN
dti-1318	1028	28	by	by	ADP
dti-1318	1028	29	hiv-1	hiv-1	NOUN
dti-1318	1028	30	protease	protease	NOUN
dti-1318	1028	31	.	.	PUNCT
dti-1318	1029	1	protein	protein	NOUN
dti-1318	1029	2	.	.	PUNCT
dti-1318	1030	1	eng	eng	PROPN
dti-1318	1030	2	.	.	PROPN
dti-1318	1030	3	,	,	PUNCT
dti-1318	1030	4	13:431–436	13:431–436	NUM
dti-1318	1030	5	.	.	PUNCT
dti-1318	1031	1	sheehy	sheehy	PROPN
dti-1318	1031	2	,	,	PUNCT
dti-1318	1031	3	a.m.	a.m.	ADV
dti-1318	1031	4	,	,	PUNCT
dti-1318	1031	5	gaddis	gaddis	PROPN
dti-1318	1031	6	,	,	PUNCT
dti-1318	1031	7	n.c	n.c	PROPN
dti-1318	1031	8	.	.	PROPN
dti-1318	1031	9	and	and	CCONJ
dti-1318	1031	10	malim	malim	PROPN
dti-1318	1031	11	,	,	PUNCT
dti-1318	1031	12	m.h	m.h	PROPN
dti-1318	1031	13	.	.	PROPN
dti-1318	1031	14	2003	2003	NUM
dti-1318	1031	15	.	.	PUNCT
dti-1318	1032	1	the	the	DET
dti-1318	1032	2	antiretroviral	antiretroviral	ADJ
dti-1318	1032	3	enzyme	enzyme	NOUN
dti-1318	1032	4	apobec3	apobec3	ADP
dti-1318	1032	5	g	g	NOUN
dti-1318	1032	6	is	be	AUX
dti-1318	1032	7	degraded	degrade	VERB
dti-1318	1032	8	by	by	ADP
dti-1318	1032	9	the	the	DET
dti-1318	1032	10	proteasome	proteasome	NOUN
dti-1318	1032	11	in	in	ADP
dti-1318	1032	12	response	response	NOUN
dti-1318	1032	13	to	to	ADP
dti-1318	1032	14	hiv-1	hiv-1	X
dti-1318	1032	15	vif	vif	PROPN
dti-1318	1032	16	.	.	PUNCT
dti-1318	1033	1	nat	nat	PROPN
dti-1318	1033	2	.	.	PUNCT
dti-1318	1034	1	med	med	PROPN
dti-1318	1034	2	.	.	PROPN
dti-1318	1034	3	,	,	PUNCT
dti-1318	1034	4	9:1404–1407	9:1404–1407	X
dti-1318	1034	5	.	.	PUNCT
dti-1318	1034	6	shehu	shehu	PROPN
dti-1318	1034	7	-	-	PUNCT
dti-1318	1034	8	xhilaga	xhilaga	PROPN
dti-1318	1034	9	,	,	PUNCT
dti-1318	1034	10	m.	m.	NOUN
dti-1318	1034	11	,	,	PUNCT
dti-1318	1034	12	crowe	crowe	PROPN
dti-1318	1034	13	,	,	PUNCT
dti-1318	1034	14	s.m	s.m	PROPN
dti-1318	1034	15	.	.	PROPN
dti-1318	1034	16	and	and	CCONJ
dti-1318	1034	17	mak	mak	PROPN
dti-1318	1034	18	,	,	PUNCT
dti-1318	1034	19	j.	j.	PROPN
dti-1318	1034	20	2001a	2001a	PROPN
dti-1318	1034	21	.	.	PUNCT
dti-1318	1035	1	maintenance	maintenance	NOUN
dti-1318	1035	2	of	of	ADP
dti-1318	1035	3	the	the	DET
dti-1318	1035	4	gag	gag	NOUN
dti-1318	1035	5	/	/	SYM
dti-1318	1035	6	gag	gag	NOUN
dti-1318	1035	7	-	-	PUNCT
dti-1318	1035	8	pol	pol	NOUN
dti-1318	1035	9	ratio	ratio	NOUN
dti-1318	1035	10	is	be	AUX
dti-1318	1035	11	important	important	ADJ
dti-1318	1035	12	for	for	ADP
dti-1318	1035	13	human	human	ADJ
dti-1318	1035	14	immunodefi	immunodefi	PROPN
dti-1318	1035	15	ciency	ciency	NOUN
dti-1318	1035	16	virus	virus	NOUN
dti-1318	1035	17	type	type	NOUN
dti-1318	1035	18	1	1	NUM
dti-1318	1035	19	rna	rna	NOUN
dti-1318	1035	20	dimerization	dimerization	NOUN
dti-1318	1035	21	and	and	CCONJ
dti-1318	1035	22	viral	viral	ADJ
dti-1318	1035	23	infectivity	infectivity	NOUN
dti-1318	1035	24	.	.	PUNCT
dti-1318	1036	1	j.	j.	PROPN
dti-1318	1036	2	virol	virol	PROPN
dti-1318	1036	3	.	.	PUNCT
dti-1318	1036	4	,	,	PUNCT
dti-1318	1036	5	75:1834–1841	75:1834–1841	NUM
dti-1318	1036	6	.	.	PUNCT
dti-1318	1036	7	shehu	shehu	PROPN
dti-1318	1036	8	-	-	PUNCT
dti-1318	1036	9	xhilaga	xhilaga	PROPN
dti-1318	1036	10	,	,	PUNCT
dti-1318	1036	11	m.	m.	NOUN
dti-1318	1036	12	,	,	PUNCT
dti-1318	1036	13	kraeusslich	kraeusslich	PROPN
dti-1318	1036	14	,	,	PUNCT
dti-1318	1036	15	h.g	h.g	PROPN
dti-1318	1036	16	.	.	PROPN
dti-1318	1036	17	,	,	PUNCT
dti-1318	1036	18	pettit	pettit	PROPN
dti-1318	1036	19	,	,	PUNCT
dti-1318	1036	20	s.	s.	PROPN
dti-1318	1036	21	,	,	PUNCT
dti-1318	1036	22	swanstrom	swanstrom	PROPN
dti-1318	1036	23	,	,	PUNCT
dti-1318	1036	24	r.	r.	PROPN
dti-1318	1036	25	,	,	PUNCT
dti-1318	1036	26	lee	lee	PROPN
dti-1318	1036	27	,	,	PUNCT
dti-1318	1036	28	j.y	j.y	PROPN
dti-1318	1036	29	.	.	PROPN
dti-1318	1036	30	,	,	PUNCT
dti-1318	1036	31	marshall	marshall	PROPN
dti-1318	1036	32	,	,	PUNCT
dti-1318	1036	33	j.a	j.a	PROPN
dti-1318	1036	34	.	.	PROPN
dti-1318	1036	35	,	,	PUNCT
dti-1318	1036	36	crowe	crowe	PROPN
dti-1318	1036	37	,	,	PUNCT
dti-1318	1036	38	s.m	s.m	PROPN
dti-1318	1036	39	.	.	PROPN
dti-1318	1036	40	and	and	CCONJ
dti-1318	1036	41	mak	mak	PROPN
dti-1318	1036	42	,	,	PUNCT
dti-1318	1036	43	j.	j.	PROPN
dti-1318	1036	44	2001b	2001b	NUM
dti-1318	1036	45	.	.	PUNCT
dti-1318	1037	1	proteolytic	proteolytic	ADJ
dti-1318	1037	2	processing	processing	NOUN
dti-1318	1037	3	of	of	ADP
dti-1318	1037	4	the	the	DET
dti-1318	1037	5	p2	p2	NOUN
dti-1318	1037	6	/	/	SYM
dti-1318	1037	7	nucleocapsid	nucleocapsid	ADJ
dti-1318	1037	8	cleavage	cleavage	NOUN
dti-1318	1037	9	site	site	NOUN
dti-1318	1037	10	is	be	AUX
dti-1318	1037	11	critical	critical	ADJ
dti-1318	1037	12	for	for	ADP
dti-1318	1037	13	human	human	ADJ
dti-1318	1037	14	immunodefi	immunodefi	PROPN
dti-1318	1037	15	ciency	ciency	NOUN
dti-1318	1037	16	virus	virus	NOUN
dti-1318	1037	17	type	type	NOUN
dti-1318	1037	18	1	1	NUM
dti-1318	1037	19	rna	rna	NOUN
dti-1318	1037	20	dimer	dimer	NOUN
dti-1318	1037	21	maturation	maturation	NOUN
dti-1318	1037	22	.	.	PUNCT
dti-1318	1038	1	j.	j.	PROPN
dti-1318	1038	2	virol	virol	PROPN
dti-1318	1038	3	.	.	PUNCT
dti-1318	1038	4	,	,	PUNCT
dti-1318	1038	5	75	75	NUM
dti-1318	1038	6	:	:	PUNCT
dti-1318	1038	7	9156–9164	9156–9164	NOUN
dti-1318	1038	8	.	.	PUNCT
dti-1318	1039	1	shehu	shehu	NOUN
dti-1318	1039	2	-	-	PUNCT
dti-1318	1039	3	xhilaga	xhilaga	PROPN
dti-1318	1039	4	,	,	PUNCT
dti-1318	1039	5	m.	m.	NOUN
dti-1318	1039	6	,	,	PUNCT
dti-1318	1039	7	tachedjian	tachedjian	NOUN
dti-1318	1039	8	,	,	PUNCT
dti-1318	1039	9	g.	g.	PROPN
dti-1318	1039	10	,	,	PUNCT
dti-1318	1039	11	crowe	crowe	PROPN
dti-1318	1039	12	,	,	PUNCT
dti-1318	1039	13	s.m	s.m	PROPN
dti-1318	1039	14	.	.	PROPN
dti-1318	1039	15	and	and	CCONJ
dti-1318	1039	16	kedzierska	kedzierska	PROPN
dti-1318	1039	17	,	,	PUNCT
dti-1318	1039	18	k.	k.	PROPN
dti-1318	1039	19	2005	2005	NUM
dti-1318	1039	20	.	.	PUNCT
dti-1318	1040	1	antiretroviral	antiretroviral	ADJ
dti-1318	1040	2	compounds	compound	NOUN
dti-1318	1040	3	:	:	PUNCT
dti-1318	1040	4	mechanisms	mechanism	VERB
dti-1318	1040	5	underlying	underlying	ADJ
dti-1318	1040	6	failure	failure	NOUN
dti-1318	1040	7	of	of	ADP
dti-1318	1040	8	haart	haart	PROPN
dti-1318	1040	9	to	to	PART
dti-1318	1040	10	eradicate	eradicate	VERB
dti-1318	1040	11	hiv-1	hiv-1	NOUN
dti-1318	1040	12	.	.	PUNCT
dti-1318	1041	1	curr	curr	AUX
dti-1318	1041	2	.	.	PUNCT
dti-1318	1041	3	med	med	PROPN
dti-1318	1041	4	.	.	PROPN
dti-1318	1041	5	chem	chem	PROPN
dti-1318	1041	6	.	.	PUNCT
dti-1318	1041	7	,	,	PUNCT
dti-1318	1041	8	12:1705–1719	12:1705–1719	PROPN
dti-1318	1041	9	.	.	PUNCT
dti-1318	1042	1	shin	shin	PROPN
dti-1318	1042	2	,	,	PUNCT
dti-1318	1042	3	c.g	c.g	PROPN
dti-1318	1042	4	.	.	PROPN
dti-1318	1042	5	,	,	PUNCT
dti-1318	1042	6	taddeo	taddeo	PROPN
dti-1318	1042	7	,	,	PUNCT
dti-1318	1042	8	b.	b.	PROPN
dti-1318	1042	9	,	,	PUNCT
dti-1318	1042	10	haseltine	haseltine	PROPN
dti-1318	1042	11	,	,	PUNCT
dti-1318	1042	12	w.a	w.a	PROPN
dti-1318	1042	13	.	.	PROPN
dti-1318	1042	14	and	and	CCONJ
dti-1318	1042	15	farnet	farnet	PROPN
dti-1318	1042	16	,	,	PUNCT
dti-1318	1042	17	c.m	c.m	PROPN
dti-1318	1042	18	.	.	PROPN
dti-1318	1042	19	1994	1994	NUM
dti-1318	1042	20	.	.	PUNCT
dti-1318	1043	1	genetic	genetic	ADJ
dti-1318	1043	2	analysis	analysis	NOUN
dti-1318	1043	3	of	of	ADP
dti-1318	1043	4	the	the	DET
dti-1318	1043	5	human	human	ADJ
dti-1318	1043	6	immunodefi	immunodefi	PROPN
dti-1318	1043	7	ciency	ciency	NOUN
dti-1318	1043	8	virus	virus	NOUN
dti-1318	1043	9	type	type	NOUN
dti-1318	1043	10	1	1	NUM
dti-1318	1043	11	integrase	integrase	NOUN
dti-1318	1043	12	protein	protein	NOUN
dti-1318	1043	13	.	.	PUNCT
dti-1318	1044	1	j.	j.	PROPN
dti-1318	1044	2	virol	virol	PROPN
dti-1318	1044	3	.	.	PUNCT
dti-1318	1044	4	,	,	PUNCT
dti-1318	1044	5	68:1633–1642	68:1633–1642	NUM
dti-1318	1044	6	.	.	PUNCT
dti-1318	1045	1	shkriabai	shkriabai	PROPN
dti-1318	1045	2	,	,	PUNCT
dti-1318	1045	3	n.	n.	NOUN
dti-1318	1045	4	,	,	PUNCT
dti-1318	1045	5	datta	datta	PROPN
dti-1318	1045	6	,	,	PUNCT
dti-1318	1045	7	s.a	s.a	PROPN
dti-1318	1045	8	.	.	PROPN
dti-1318	1045	9	,	,	PUNCT
dti-1318	1045	10	zhao	zhao	PROPN
dti-1318	1045	11	,	,	PUNCT
dti-1318	1045	12	z.	z.	PROPN
dti-1318	1045	13	,	,	PUNCT
dti-1318	1045	14	hess	hess	PROPN
dti-1318	1045	15	,	,	PUNCT
dti-1318	1045	16	s.	s.	PROPN
dti-1318	1045	17	,	,	PUNCT
dti-1318	1045	18	rein	rein	NOUN
dti-1318	1045	19	,	,	PUNCT
dti-1318	1045	20	and	and	CCONJ
dti-1318	1045	21	a.	a.	NOUN
dti-1318	1045	22	kvaratskhelia	kvaratskhelia	PROPN
dti-1318	1045	23	,	,	PUNCT
dti-1318	1045	24	m.	m.	NOUN
dti-1318	1045	25	2006	2006	NUM
dti-1318	1045	26	.	.	PUNCT
dti-1318	1046	1	interactions	interaction	NOUN
dti-1318	1046	2	of	of	ADP
dti-1318	1046	3	hiv-1	hiv-1	X
dti-1318	1046	4	gag	gag	NOUN
dti-1318	1046	5	with	with	ADP
dti-1318	1046	6	assembly	assembly	NOUN
dti-1318	1046	7	cofactors	cofactor	NOUN
dti-1318	1046	8	.	.	PUNCT
dti-1318	1047	1	biochemistry	biochemistry	NOUN
dti-1318	1047	2	,	,	PUNCT
dti-1318	1047	3	45:4077–4083	45:4077–4083	PROPN
dti-1318	1047	4	.	.	PUNCT
dti-1318	1047	5	sluis	sluis	NOUN
dti-1318	1047	6	-	-	PUNCT
dti-1318	1047	7	cremer	cremer	NOUN
dti-1318	1047	8	,	,	PUNCT
dti-1318	1047	9	n.	n.	NOUN
dti-1318	1047	10	,	,	PUNCT
dti-1318	1047	11	arion	arion	NOUN
dti-1318	1047	12	,	,	PUNCT
dti-1318	1047	13	d.	d.	PROPN
dti-1318	1047	14	,	,	PUNCT
dti-1318	1047	15	abram	abram	PROPN
dti-1318	1047	16	,	,	PUNCT
dti-1318	1047	17	m.e	m.e	PROPN
dti-1318	1047	18	.	.	PROPN
dti-1318	1047	19	and	and	CCONJ
dti-1318	1047	20	parniak	parniak	PROPN
dti-1318	1047	21	,	,	PUNCT
dti-1318	1047	22	m.a	m.a	PROPN
dti-1318	1047	23	.	.	PROPN
dti-1318	1047	24	2004	2004	NUM
dti-1318	1047	25	.	.	PUNCT
dti-1318	1048	1	proteolytic	proteolytic	ADJ
dti-1318	1048	2	processing	processing	NOUN
dti-1318	1048	3	of	of	ADP
dti-1318	1048	4	an	an	DET
dti-1318	1048	5	hiv-1	hiv-1	ADJ
dti-1318	1048	6	pol	pol	NOUN
dti-1318	1048	7	polyprotein	polyprotein	ADJ
dti-1318	1048	8	precursor	precursor	NOUN
dti-1318	1048	9	:	:	PUNCT
dti-1318	1048	10	insights	insight	NOUN
dti-1318	1048	11	into	into	ADP
dti-1318	1048	12	the	the	DET
dti-1318	1048	13	mechanism	mechanism	NOUN
dti-1318	1048	14	of	of	ADP
dti-1318	1048	15	reverse	reverse	ADJ
dti-1318	1048	16	transcriptase	transcriptase	NOUN
dti-1318	1048	17	p66	p66	PROPN
dti-1318	1048	18	/	/	SYM
dti-1318	1048	19	p51	p51	PROPN
dti-1318	1048	20	heterodimer	heterodimer	PROPN
dti-1318	1048	21	formation	formation	PROPN
dti-1318	1048	22	.	.	PUNCT
dti-1318	1049	1	int	int	NOUN
dti-1318	1049	2	.	.	PUNCT
dti-1318	1050	1	j.	j.	PROPN
dti-1318	1050	2	biochem	biochem	PROPN
dti-1318	1050	3	.	.	PUNCT
dti-1318	1051	1	cell	cell	NOUN
dti-1318	1051	2	.	.	PUNCT
dti-1318	1052	1	biol	biol	PROPN
dti-1318	1052	2	.	.	PUNCT
dti-1318	1052	3	,	,	PUNCT
dti-1318	1052	4	36:1836–1847	36:1836–1847	PROPN
dti-1318	1052	5	.	.	PUNCT
dti-1318	1052	6	sluis	sluis	NOUN
dti-1318	1052	7	-	-	PUNCT
dti-1318	1052	8	cremer	cremer	NOUN
dti-1318	1052	9	,	,	PUNCT
dti-1318	1052	10	n.	n.	NOUN
dti-1318	1052	11	,	,	PUNCT
dti-1318	1052	12	dmitrienko	dmitrienko	PROPN
dti-1318	1052	13	,	,	PUNCT
dti-1318	1052	14	g.i	g.i	PROPN
dti-1318	1052	15	.	.	PROPN
dti-1318	1052	16	,	,	PUNCT
dti-1318	1052	17	balzarini	balzarini	PROPN
dti-1318	1052	18	,	,	PUNCT
dti-1318	1052	19	j.	j.	PROPN
dti-1318	1052	20	,	,	PUNCT
dti-1318	1052	21	camarasa	camarasa	PROPN
dti-1318	1052	22	,	,	PUNCT
dti-1318	1052	23	m.j	m.j	PROPN
dti-1318	1052	24	.	.	PROPN
dti-1318	1052	25	and	and	CCONJ
dti-1318	1052	26	parniak	parniak	PROPN
dti-1318	1052	27	,	,	PUNCT
dti-1318	1052	28	m.a	m.a	PROPN
dti-1318	1052	29	.	.	PROPN
dti-1318	1052	30	2000	2000	NUM
dti-1318	1052	31	.	.	PUNCT
dti-1318	1053	1	human	human	ADJ
dti-1318	1053	2	immunodefi	immunodefi	PROPN
dti-1318	1053	3	ciency	ciency	NOUN
dti-1318	1053	4	virus	virus	NOUN
dti-1318	1053	5	type	type	NOUN
dti-1318	1053	6	1	1	NUM
dti-1318	1053	7	reverse	reverse	NOUN
dti-1318	1053	8	transcriptase	transcriptase	NOUN
dti-1318	1053	9	dimer	dimer	NOUN
dti-1318	1053	10	destabilization	destabilization	NOUN
dti-1318	1053	11	by	by	ADP
dti-1318	1053	12	1-[spiro[4″-amino-2″,2″-dioxo-1″,2″	1-[spiro[4″-amino-2″,2″-dioxo-1″,2″	NUM
dti-1318	1053	13	oxathiole-5″,3′-[2′	oxathiole-5″,3′-[2′	PROPN
dti-1318	1053	14	,	,	PUNCT
dti-1318	1053	15	5′-bis	5′-bis	PROPN
dti-1318	1053	16	-	-	PUNCT
dti-1318	1053	17	o-(tert	o-(tert	PROPN
dti-1318	1053	18	-	-	PUNCT
dti-1318	1053	19	butyldimethylsilyl)-beta	butyldimethylsilyl)-beta	PROPN
dti-1318	1053	20	-	-	ADJ
dti-1318	1053	21	d	d	NOUN
dti-1318	1053	22	-	-	PUNCT
dti-1318	1053	23	ribofuranosyl]]]-3	ribofuranosyl]]]-3	VERB
dti-1318	1053	24	-	-	PUNCT
dti-1318	1053	25	ethylthy	ethylthy	ADJ
dti-1318	1053	26	mine	mine	NOUN
dti-1318	1053	27	.	.	PUNCT
dti-1318	1054	1	biochemistry	biochemistry	NOUN
dti-1318	1054	2	,	,	PUNCT
dti-1318	1054	3	39:1427–1433	39:1427–1433	NUM
dti-1318	1054	4	.	.	PUNCT
dti-1318	1054	5	-cremer	-cremer	PROPN
dti-1318	1054	6	,	,	PUNCT
dti-1318	1054	7	n.	n.	NOUN
dti-1318	1054	8	,	,	PUNCT
dti-1318	1054	9	hamamouch	hamamouch	NOUN
dti-1318	1054	10	,	,	PUNCT
dti-1318	1054	11	n.	n.	NOUN
dti-1318	1054	12	,	,	PUNCT
dti-1318	1054	13	san	san	PROPN
dti-1318	1054	14	felix	felix	PROPN
dti-1318	1054	15	,	,	PUNCT
dti-1318	1054	16	a.	a.	PROPN
dti-1318	1054	17	,	,	PUNCT
dti-1318	1054	18	velazquez	velazquez	PROPN
dti-1318	1054	19	,	,	PUNCT
dti-1318	1054	20	s.	s.	PROPN
dti-1318	1054	21	,	,	PUNCT
dti-1318	1054	22	balzarini	balzarini	PROPN
dti-1318	1054	23	,	,	PUNCT
dti-1318	1054	24	j.	j.	PROPN
dti-1318	1054	25	and	and	CCONJ
dti-1318	1054	26	camarasa	camarasa	PROPN
dti-1318	1054	27	,	,	PUNCT
dti-1318	1054	28	m.j	m.j	PROPN
dti-1318	1054	29	.	.	PROPN
dti-1318	1054	30	2006	2006	NUM
dti-1318	1054	31	.	.	PUNCT
dti-1318	1055	1	structure	structure	NOUN
dti-1318	1055	2	-	-	PUNCT
dti-1318	1055	3	activity	activity	NOUN
dti-1318	1055	4	relationships	relationship	NOUN
dti-1318	1055	5	of	of	ADP
dti-1318	1055	6	[	[	PUNCT
dti-1318	1055	7	2′,5′bis	2′,5′bis	NUM
dti-1318	1055	8	-	-	PUNCT
dti-1318	1055	9	o-(tert	o-(tert	PROPN
dti-1318	1055	10	-	-	PUNCT
dti-1318	1055	11	butyldimethylsilyl)-beta	butyldimethylsilyl)-beta	PROPN
dti-1318	1055	12	-	-	PUNCT
dti-1318	1055	13	d	d	NOUN
dti-1318	1055	14	-	-	PUNCT
dti-1318	1055	15	ribofuranosyl]3′-spiro-5″(4″-amino-1″,2″-oxathiole-2″,2″-dioxide)thymine	ribofuranosyl]3′-spiro-5″(4″-amino-1″,2″-oxathiole-2″,2″-dioxide)thymine	ADJ
dti-1318	1055	16	derivatives	derivative	NOUN
dti-1318	1055	17	as	as	ADP
dti-1318	1055	18	inhibitors	inhibitor	NOUN
dti-1318	1055	19	of	of	ADP
dti-1318	1055	20	hiv-1	hiv-1	X
dti-1318	1055	21	reverse	reverse	ADJ
dti-1318	1055	22	transcriptase	transcriptase	NOUN
dti-1318	1055	23	dimerization	dimerization	NOUN
dti-1318	1055	24	.	.	PUNCT
dti-1318	1056	1	j.	j.	PROPN
dti-1318	1056	2	med	med	PROPN
dti-1318	1056	3	.	.	PROPN
dti-1318	1056	4	chem	chem	PROPN
dti-1318	1056	5	.	.	PUNCT
dti-1318	1056	6	,	,	PUNCT
dti-1318	1056	7	49:4834–4841	49:4834–4841	PROPN
dti-1318	1056	8	.	.	PUNCT
dti-1318	1057	1	sluis	sluis	NOUN
dti-1318	1057	2	-	-	PUNCT
dti-1318	1057	3	cremer	cremer	NOUN
dti-1318	1057	4	,	,	PUNCT
dti-1318	1057	5	n.	n.	NOUN
dti-1318	1057	6	and	and	CCONJ
dti-1318	1057	7	tachedjian	tachedjian	NOUN
dti-1318	1057	8	,	,	PUNCT
dti-1318	1057	9	g.	g.	PROPN
dti-1318	1057	10	2002	2002	NUM
dti-1318	1057	11	.	.	PUNCT
dti-1318	1058	1	modulation	modulation	NOUN
dti-1318	1058	2	of	of	ADP
dti-1318	1058	3	the	the	DET
dti-1318	1058	4	oligomeric	oligomeric	ADJ
dti-1318	1058	5	structures	structure	NOUN
dti-1318	1058	6	of	of	ADP
dti-1318	1058	7	hiv-1	hiv-1	ADJ
dti-1318	1058	8	retroviral	retroviral	ADJ
dti-1318	1058	9	enzymes	enzyme	NOUN
dti-1318	1058	10	by	by	ADP
dti-1318	1058	11	synthetic	synthetic	ADJ
dti-1318	1058	12	peptides	peptide	NOUN
dti-1318	1058	13	and	and	CCONJ
dti-1318	1058	14	small	small	ADJ
dti-1318	1058	15	molecules	molecule	NOUN
dti-1318	1058	16	.	.	PUNCT
dti-1318	1059	1	eur	eur	PROPN
dti-1318	1059	2	.	.	PUNCT
dti-1318	1060	1	j.	j.	PROPN
dti-1318	1060	2	biochem	biochem	PROPN
dti-1318	1060	3	.	.	PUNCT
dti-1318	1060	4	,	,	PUNCT
dti-1318	1061	1	269:5103–5111	269:5103–5111	NUM
dti-1318	1061	2	.	.	PUNCT
dti-1318	1062	1	smith	smith	PROPN
dti-1318	1062	2	,	,	PUNCT
dti-1318	1062	3	a.j	a.j	PROPN
dti-1318	1062	4	.	.	PROPN
dti-1318	1062	5	,	,	PUNCT
dti-1318	1062	6	srinivasakumar	srinivasakumar	PROPN
dti-1318	1062	7	,	,	PUNCT
dti-1318	1062	8	n.	n.	NOUN
dti-1318	1062	9	,	,	PUNCT
dti-1318	1062	10	hammarskjold	hammarskjold	NOUN
dti-1318	1062	11	,	,	PUNCT
dti-1318	1062	12	m.l	m.l	PROPN
dti-1318	1062	13	.	.	PROPN
dti-1318	1062	14	and	and	CCONJ
dti-1318	1062	15	rekosh	rekosh	PROPN
dti-1318	1062	16	,	,	PUNCT
dti-1318	1062	17	d.	d.	PROPN
dti-1318	1062	18	1993	1993	NUM
dti-1318	1062	19	.	.	PUNCT
dti-1318	1063	1	requirements	requirement	NOUN
dti-1318	1063	2	for	for	ADP
dti-1318	1063	3	incorporation	incorporation	NOUN
dti-1318	1063	4	of	of	ADP
dti-1318	1063	5	pr160gag	pr160gag	NOUN
dti-1318	1063	6	-	-	PUNCT
dti-1318	1063	7	pol	pol	NOUN
dti-1318	1063	8	from	from	ADP
dti-1318	1063	9	human	human	ADJ
dti-1318	1063	10	immunodefi	immunodefi	PROPN
dti-1318	1063	11	ciency	ciency	NOUN
dti-1318	1063	12	virus	virus	NOUN
dti-1318	1063	13	type	type	NOUN
dti-1318	1063	14	1	1	NUM
dti-1318	1063	15	into	into	ADP
dti-1318	1063	16	virus	virus	NOUN
dti-1318	1063	17	-	-	PUNCT
dti-1318	1063	18	like	like	ADJ
dti-1318	1063	19	particles	particle	NOUN
dti-1318	1063	20	.	.	PUNCT
dti-1318	1064	1	j.	j.	PROPN
dti-1318	1064	2	virol	virol	PROPN
dti-1318	1064	3	.	.	PUNCT
dti-1318	1064	4	,	,	PUNCT
dti-1318	1064	5	67	67	NUM
dti-1318	1064	6	:	:	SYM
dti-1318	1064	7	2266–2275	2266–2275	NUM
dti-1318	1064	8	.	.	PUNCT
dti-1318	1064	9	song	song	NOUN
dti-1318	1064	10	,	,	PUNCT
dti-1318	1064	11	m.	m.	NOUN
dti-1318	1064	12	,	,	PUNCT
dti-1318	1064	13	rajesh	rajesh	PROPN
dti-1318	1064	14	,	,	PUNCT
dti-1318	1064	15	s.	s.	PROPN
dti-1318	1064	16	,	,	PUNCT
dti-1318	1064	17	hayashi	hayashi	PROPN
dti-1318	1064	18	,	,	PUNCT
dti-1318	1064	19	y.	y.	PROPN
dti-1318	1064	20	and	and	CCONJ
dti-1318	1064	21	kiso	kiso	PROPN
dti-1318	1064	22	,	,	PUNCT
dti-1318	1064	23	y.	y.	PROPN
dti-1318	1064	24	2001	2001	NUM
dti-1318	1064	25	.	.	PUNCT
dti-1318	1065	1	design	design	NOUN
dti-1318	1065	2	and	and	CCONJ
dti-1318	1065	3	synthesis	synthesis	NOUN
dti-1318	1065	4	of	of	ADP
dti-1318	1065	5	new	new	ADJ
dti-1318	1065	6	inhibitors	inhibitor	NOUN
dti-1318	1065	7	of	of	ADP
dti-1318	1065	8	hiv-1	hiv-1	X
dti-1318	1065	9	protease	protease	NOUN
dti-1318	1065	10	dimerization	dimerization	NOUN
dti-1318	1065	11	with	with	ADP
dti-1318	1065	12	conformationally	conformationally	ADV
dti-1318	1065	13	constrained	constrain	VERB
dti-1318	1065	14	templates	template	NOUN
dti-1318	1065	15	.	.	PUNCT
dti-1318	1066	1	bioorg	bioorg	PROPN
dti-1318	1066	2	.	.	PUNCT
dti-1318	1067	1	med	med	PROPN
dti-1318	1067	2	.	.	PROPN
dti-1318	1067	3	chem	chem	PROPN
dti-1318	1067	4	.	.	PUNCT
dti-1318	1068	1	lett	lett	PROPN
dti-1318	1068	2	.	.	PROPN
dti-1318	1068	3	,	,	PUNCT
dti-1318	1068	4	11:2465	11:2465	NUM
dti-1318	1068	5	–	–	PUNCT
dti-1318	1068	6	2468	2468	NUM
dti-1318	1068	7	.	.	PUNCT
dti-1318	1069	1	sorin	sorin	NOUN
dti-1318	1069	2	,	,	PUNCT
dti-1318	1069	3	m.	m.	NOUN
dti-1318	1069	4	,	,	PUNCT
dti-1318	1069	5	yung	yung	PROPN
dti-1318	1069	6	,	,	PUNCT
dti-1318	1069	7	e.	e.	PROPN
dti-1318	1069	8	,	,	PUNCT
dti-1318	1069	9	wu	wu	PROPN
dti-1318	1069	10	,	,	PUNCT
dti-1318	1069	11	x.	x.	NOUN
dti-1318	1069	12	and	and	CCONJ
dti-1318	1069	13	kalpana	kalpana	PROPN
dti-1318	1069	14	,	,	PUNCT
dti-1318	1069	15	g.v	g.v	PROPN
dti-1318	1069	16	.	.	PROPN
dti-1318	1069	17	2006	2006	NUM
dti-1318	1069	18	.	.	PUNCT
dti-1318	1070	1	hiv-1	hiv-1	X
dti-1318	1070	2	replication	replication	NOUN
dti-1318	1070	3	in	in	ADP
dti-1318	1070	4	cell	cell	NOUN
dti-1318	1070	5	lines	line	NOUN
dti-1318	1070	6	harboring	harbor	VERB
dti-1318	1070	7	ini1	ini1	PROPN
dti-1318	1070	8	/	/	SYM
dti-1318	1070	9	hsnf5	hsnf5	NOUN
dti-1318	1070	10	mutations	mutation	NOUN
dti-1318	1070	11	.	.	PUNCT
dti-1318	1071	1	retrovirology	retrovirology	NOUN
dti-1318	1071	2	,	,	PUNCT
dti-1318	1071	3	3:56	3:56	NUM
dti-1318	1071	4	.	.	PUNCT
dti-1318	1072	1	srinivasakumar	srinivasakumar	PROPN
dti-1318	1072	2	,	,	PUNCT
dti-1318	1072	3	n.	n.	NOUN
dti-1318	1072	4	,	,	PUNCT
dti-1318	1072	5	hammarskjold	hammarskjold	NOUN
dti-1318	1072	6	,	,	PUNCT
dti-1318	1072	7	m.l	m.l	PROPN
dti-1318	1072	8	.	.	PROPN
dti-1318	1072	9	and	and	CCONJ
dti-1318	1072	10	rekosh	rekosh	PROPN
dti-1318	1072	11	,	,	PUNCT
dti-1318	1072	12	d.	d.	PROPN
dti-1318	1072	13	1995	1995	NUM
dti-1318	1072	14	.	.	PUNCT
dti-1318	1073	1	characterization	characterization	NOUN
dti-1318	1073	2	of	of	ADP
dti-1318	1073	3	deletion	deletion	NOUN
dti-1318	1073	4	mutations	mutation	NOUN
dti-1318	1073	5	in	in	ADP
dti-1318	1073	6	the	the	DET
dti-1318	1073	7	capsid	capsid	ADJ
dti-1318	1073	8	region	region	NOUN
dti-1318	1073	9	of	of	ADP
dti-1318	1073	10	human	human	ADJ
dti-1318	1073	11	immunodefi	immunodefi	PROPN
dti-1318	1073	12	ciency	ciency	NOUN
dti-1318	1073	13	virus	virus	NOUN
dti-1318	1073	14	type	type	NOUN
dti-1318	1073	15	1	1	NUM
dti-1318	1073	16	that	that	PRON
dti-1318	1073	17	affect	affect	VERB
dti-1318	1073	18	particle	particle	NOUN
dti-1318	1073	19	formation	formation	NOUN
dti-1318	1073	20	and	and	CCONJ
dti-1318	1073	21	gag	gag	NOUN
dti-1318	1073	22	-	-	PUNCT
dti-1318	1073	23	pol	pol	NOUN
dti-1318	1073	24	precursor	precursor	NOUN
dti-1318	1073	25	incorporation	incorporation	NOUN
dti-1318	1073	26	.	.	PUNCT
dti-1318	1074	1	j.	j.	PROPN
dti-1318	1074	2	virol	virol	PROPN
dti-1318	1074	3	.	.	PUNCT
dti-1318	1074	4	,	,	PUNCT
dti-1318	1075	1	69:6106–6114	69:6106–6114	NUM
dti-1318	1075	2	.	.	PUNCT
dti-1318	1076	1	srivastava	srivastava	PROPN
dti-1318	1076	2	,	,	PUNCT
dti-1318	1076	3	s.	s.	PROPN
dti-1318	1076	4	,	,	PUNCT
dti-1318	1076	5	sluis	sluis	NOUN
dti-1318	1076	6	-	-	PUNCT
dti-1318	1076	7	cremer	cremer	NOUN
dti-1318	1076	8	,	,	PUNCT
dti-1318	1076	9	n.	n.	NOUN
dti-1318	1076	10	and	and	CCONJ
dti-1318	1076	11	tachedjian	tachedjian	NOUN
dti-1318	1076	12	,	,	PUNCT
dti-1318	1076	13	g.	g.	PROPN
dti-1318	1076	14	2006	2006	NUM
dti-1318	1076	15	.	.	PUNCT
dti-1318	1077	1	dimerization	dimerization	NOUN
dti-1318	1077	2	of	of	ADP
dti-1318	1077	3	human	human	ADJ
dti-1318	1077	4	immunodefi	immunodefi	PROPN
dti-1318	1077	5	ciency	ciency	NOUN
dti-1318	1077	6	virus	virus	NOUN
dti-1318	1077	7	type	type	NOUN
dti-1318	1077	8	1	1	NUM
dti-1318	1077	9	reverse	reverse	NOUN
dti-1318	1077	10	transcriptase	transcriptase	NOUN
dti-1318	1077	11	as	as	ADP
dti-1318	1077	12	an	an	DET
dti-1318	1077	13	antiviral	antiviral	ADJ
dti-1318	1077	14	target	target	NOUN
dti-1318	1077	15	.	.	PUNCT
dti-1318	1078	1	curr	curr	PROPN
dti-1318	1078	2	.	.	PUNCT
dti-1318	1079	1	pharm	pharm	PROPN
dti-1318	1079	2	.	.	PUNCT
dti-1318	1080	1	des	des	PROPN
dti-1318	1080	2	.	.	PROPN
dti-1318	1080	3	,	,	PUNCT
dti-1318	1080	4	12:1879–1894	12:1879–1894	NUM
dti-1318	1080	5	.	.	PUNCT
dti-1318	1081	1	stephenson	stephenson	PROPN
dti-1318	1081	2	,	,	PUNCT
dti-1318	1081	3	j.	j.	PROPN
dti-1318	1081	4	2007	2007	NUM
dti-1318	1081	5	.	.	PUNCT
dti-1318	1082	1	researchers	researcher	NOUN
dti-1318	1082	2	buoyed	buoy	VERB
dti-1318	1082	3	by	by	ADP
dti-1318	1082	4	novel	novel	NOUN
dti-1318	1082	5	hiv	hiv	PROPN
dti-1318	1082	6	drugs	drug	NOUN
dti-1318	1082	7	:	:	PUNCT
dti-1318	1082	8	will	will	AUX
dti-1318	1082	9	expand	expand	VERB
dti-1318	1082	10	drug	drug	NOUN
dti-1318	1082	11	arsenal	arsenal	ADJ
dti-1318	1082	12	against	against	ADP
dti-1318	1082	13	resistant	resistant	ADJ
dti-1318	1082	14	virus	virus	NOUN
dti-1318	1082	15	.	.	PUNCT
dti-1318	1083	1	jama	jama	PROPN
dti-1318	1083	2	,	,	PUNCT
dti-1318	1083	3	297:1535–1536	297:1535–1536	NUM
dti-1318	1083	4	.	.	PUNCT
dti-1318	1084	1	sticht	sticht	PROPN
dti-1318	1084	2	,	,	PUNCT
dti-1318	1084	3	j.	j.	PROPN
dti-1318	1084	4	,	,	PUNCT
dti-1318	1084	5	humbert	humbert	PROPN
dti-1318	1084	6	,	,	PUNCT
dti-1318	1084	7	m.	m.	NOUN
dti-1318	1084	8	,	,	PUNCT
dti-1318	1084	9	findlow	findlow	PROPN
dti-1318	1084	10	,	,	PUNCT
dti-1318	1084	11	s.	s.	PROPN
dti-1318	1084	12	,	,	PUNCT
dti-1318	1084	13	bodem	bodem	PROPN
dti-1318	1084	14	,	,	PUNCT
dti-1318	1084	15	j.	j.	PROPN
dti-1318	1084	16	,	,	PUNCT
dti-1318	1084	17	muller	muller	PROPN
dti-1318	1084	18	,	,	PUNCT
dti-1318	1084	19	b.	b.	PROPN
dti-1318	1084	20	,	,	PUNCT
dti-1318	1084	21	dietrich	dietrich	PROPN
dti-1318	1084	22	,	,	PUNCT
dti-1318	1084	23	u.	u.	PROPN
dti-1318	1084	24	,	,	PUNCT
dti-1318	1084	25	werner	werner	PROPN
dti-1318	1084	26	,	,	PUNCT
dti-1318	1084	27	j.	j.	PROPN
dti-1318	1084	28	and	and	CCONJ
dti-1318	1084	29	krausslich	krausslich	PROPN
dti-1318	1084	30	,	,	PUNCT
dti-1318	1084	31	h.g	h.g	PROPN
dti-1318	1084	32	.	.	PROPN
dti-1318	1084	33	2005	2005	NUM
dti-1318	1084	34	.	.	PUNCT
dti-1318	1085	1	a	a	DET
dti-1318	1085	2	peptide	peptide	ADJ
dti-1318	1085	3	inhibitor	inhibitor	NOUN
dti-1318	1085	4	of	of	ADP
dti-1318	1085	5	hiv-1	hiv-1	ADJ
dti-1318	1085	6	assembly	assembly	NOUN
dti-1318	1085	7	in	in	ADP
dti-1318	1085	8	vitro	vitro	X
dti-1318	1085	9	.	.	PUNCT
dti-1318	1086	1	nat	nat	PROPN
dti-1318	1086	2	.	.	PUNCT
dti-1318	1086	3	struct	struct	NOUN
dti-1318	1086	4	.	.	PUNCT
dti-1318	1087	1	mol	mol	PROPN
dti-1318	1087	2	.	.	PUNCT
dti-1318	1088	1	biol	biol	PROPN
dti-1318	1088	2	.	.	PUNCT
dti-1318	1088	3	,	,	PUNCT
dti-1318	1089	1	12:671–677	12:671–677	NUM
dti-1318	1089	2	.	.	PUNCT
dti-1318	1090	1	181	181	NUM
dti-1318	1090	2	targeting	target	VERB
dti-1318	1090	3	the	the	DET
dti-1318	1090	4	late	late	ADJ
dti-1318	1090	5	stages	stage	NOUN
dti-1318	1090	6	of	of	ADP
dti-1318	1090	7	hiv-1	hiv-1	X
dti-1318	1090	8	replication	replication	NOUN
dti-1318	1090	9	drug	drug	NOUN
dti-1318	1090	10	target	target	NOUN
dti-1318	1090	11	insights	insight	NOUN
dti-1318	1090	12	2007	2007	NUM
dti-1318	1090	13	:	:	PUNCT
dti-1318	1090	14	2	2	NUM
dti-1318	1090	15	stopak	stopak	NOUN
dti-1318	1090	16	,	,	PUNCT
dti-1318	1090	17	k.	k.	PROPN
dti-1318	1090	18	,	,	PUNCT
dti-1318	1090	19	de	de	X
dti-1318	1090	20	noronha	noronha	NOUN
dti-1318	1090	21	,	,	PUNCT
dti-1318	1090	22	c.	c.	NOUN
dti-1318	1090	23	,	,	PUNCT
dti-1318	1090	24	yonemoto	yonemoto	NOUN
dti-1318	1090	25	,	,	PUNCT
dti-1318	1090	26	w.	w.	PROPN
dti-1318	1090	27	and	and	CCONJ
dti-1318	1090	28	greene	greene	PROPN
dti-1318	1090	29	,	,	PUNCT
dti-1318	1090	30	w.c	w.c	PROPN
dti-1318	1090	31	.	.	PROPN
dti-1318	1090	32	2003	2003	NUM
dti-1318	1090	33	.	.	PUNCT
dti-1318	1091	1	hiv-1	hiv-1	X
dti-1318	1091	2	vif	vif	NOUN
dti-1318	1091	3	blocks	block	VERB
dti-1318	1091	4	the	the	DET
dti-1318	1091	5	antiviral	antiviral	ADJ
dti-1318	1091	6	activity	activity	NOUN
dti-1318	1091	7	of	of	ADP
dti-1318	1091	8	apobec3	apobec3	NOUN
dti-1318	1091	9	g	g	NOUN
dti-1318	1091	10	by	by	ADP
dti-1318	1091	11	impairing	impair	VERB
dti-1318	1091	12	both	both	CCONJ
dti-1318	1091	13	its	its	PRON
dti-1318	1091	14	translation	translation	NOUN
dti-1318	1091	15	and	and	CCONJ
dti-1318	1091	16	intracellular	intracellular	ADJ
dti-1318	1091	17	stability	stability	NOUN
dti-1318	1091	18	.	.	PUNCT
dti-1318	1092	1	mol	mol	PROPN
dti-1318	1092	2	.	.	PROPN
dti-1318	1092	3	cell	cell	NOUN
dti-1318	1092	4	.	.	PUNCT
dti-1318	1093	1	,	,	PUNCT
dti-1318	1093	2	12:591–601	12:591–601	NUM
dti-1318	1093	3	.	.	PUNCT
dti-1318	1094	1	swanstrom	swanstrom	PROPN
dti-1318	1094	2	,	,	PUNCT
dti-1318	1094	3	r.	r.	PROPN
dti-1318	1094	4	,	,	PUNCT
dti-1318	1094	5	and	and	CCONJ
dti-1318	1094	6	j.w	j.w	PROPN
dti-1318	1094	7	.	.	PROPN
dti-1318	1094	8	wills	will	NOUN
dti-1318	1094	9	.	.	PUNCT
dti-1318	1095	1	1997	1997	NUM
dti-1318	1095	2	.	.	PUNCT
dti-1318	1096	1	synthesis	synthesis	NOUN
dti-1318	1096	2	,	,	PUNCT
dti-1318	1096	3	assembly	assembly	NOUN
dti-1318	1096	4	,	,	PUNCT
dti-1318	1096	5	and	and	CCONJ
dti-1318	1096	6	processing	processing	NOUN
dti-1318	1096	7	of	of	ADP
dti-1318	1096	8	viral	viral	ADJ
dti-1318	1096	9	proteins	protein	NOUN
dti-1318	1096	10	.	.	PUNCT
dti-1318	1097	1	in	in	ADP
dti-1318	1097	2	coffi	coffi	PROPN
dti-1318	1097	3	n	n	CCONJ
dti-1318	1097	4	,	,	PUNCT
dti-1318	1097	5	j.	j.	PROPN
dti-1318	1097	6	m.	m.	PROPN
dti-1318	1097	7	,	,	PUNCT
dti-1318	1097	8	hughes	hughes	PROPN
dti-1318	1097	9	,	,	PUNCT
dti-1318	1097	10	s.	s.	PROPN
dti-1318	1097	11	h.	h.	PROPN
dti-1318	1097	12	and	and	CCONJ
dti-1318	1097	13	varmus	varmus	PROPN
dti-1318	1097	14	h.	h.	PROPN
dti-1318	1097	15	e.	e.	PROPN
dti-1318	1097	16	(	(	PUNCT
dti-1318	1097	17	ed	ed	NOUN
dti-1318	1097	18	.	.	PUNCT
dti-1318	1097	19	)	)	PUNCT
dti-1318	1097	20	,	,	PUNCT
dti-1318	1097	21	retroviruses	retrovirus	NOUN
dti-1318	1097	22	.	.	PUNCT
dti-1318	1098	1	cold	cold	ADJ
dti-1318	1098	2	spring	spring	NOUN
dti-1318	1098	3	harbor	harbor	PROPN
dti-1318	1098	4	laboratory	laboratory	PROPN
dti-1318	1098	5	press	press	PROPN
dti-1318	1098	6	,	,	PUNCT
dti-1318	1098	7	cold	cold	ADJ
dti-1318	1098	8	spring	spring	NOUN
dti-1318	1098	9	harbor	harbor	NOUN
dti-1318	1098	10	,	,	PUNCT
dti-1318	1098	11	n.y	n.y	PROPN
dti-1318	1098	12	.	.	PROPN
dti-1318	1098	13	,	,	PUNCT
dti-1318	1098	14	p.	p.	PROPN
dti-1318	1098	15	263–334	263–334	NUM
dti-1318	1098	16	.	.	PUNCT
dti-1318	1099	1	tachedjian	tachedjian	NOUN
dti-1318	1099	2	,	,	PUNCT
dti-1318	1099	3	g.	g.	PROPN
dti-1318	1099	4	,	,	PUNCT
dti-1318	1099	5	aronson	aronson	PROPN
dti-1318	1099	6	,	,	PUNCT
dti-1318	1099	7	h.e	h.e	PROPN
dti-1318	1099	8	.	.	PROPN
dti-1318	1099	9	,	,	PUNCT
dti-1318	1099	10	de	de	PROPN
dti-1318	1099	11	los	los	PROPN
dti-1318	1099	12	santos	santos	PROPN
dti-1318	1099	13	,	,	PUNCT
dti-1318	1099	14	m.	m.	NOUN
dti-1318	1099	15	,	,	PUNCT
dti-1318	1099	16	seehra	seehra	PROPN
dti-1318	1099	17	,	,	PUNCT
dti-1318	1099	18	j.	j.	PROPN
dti-1318	1099	19	,	,	PUNCT
dti-1318	1099	20	mccoy	mccoy	PROPN
dti-1318	1099	21	,	,	PUNCT
dti-1318	1099	22	j.m	j.m	PROPN
dti-1318	1099	23	.	.	PROPN
dti-1318	1099	24	and	and	CCONJ
dti-1318	1099	25	goff	goff	PROPN
dti-1318	1099	26	,	,	PUNCT
dti-1318	1099	27	s.p	s.p	PROPN
dti-1318	1099	28	.	.	PROPN
dti-1318	1099	29	2003	2003	NUM
dti-1318	1099	30	.	.	PUNCT
dti-1318	1100	1	role	role	NOUN
dti-1318	1100	2	of	of	ADP
dti-1318	1100	3	residues	residue	NOUN
dti-1318	1100	4	in	in	ADP
dti-1318	1100	5	the	the	DET
dti-1318	1100	6	tryptophan	tryptophan	NOUN
dti-1318	1100	7	repeat	repeat	NOUN
dti-1318	1100	8	motif	motif	NOUN
dti-1318	1100	9	for	for	ADP
dti-1318	1100	10	hiv-1	hiv-1	PUNCT
dti-1318	1100	11	reverse	reverse	VERB
dti-1318	1100	12	transcriptase	transcriptase	NOUN
dti-1318	1100	13	dimerization	dimerization	NOUN
dti-1318	1100	14	.	.	PUNCT
dti-1318	1101	1	j.	j.	PROPN
dti-1318	1101	2	mol	mol	PROPN
dti-1318	1101	3	.	.	PUNCT
dti-1318	1102	1	biol	biol	PROPN
dti-1318	1102	2	.	.	PUNCT
dti-1318	1102	3	,	,	PUNCT
dti-1318	1103	1	326:381	326:381	NUM
dti-1318	1103	2	–	–	PUNCT
dti-1318	1103	3	396	396	NUM
dti-1318	1103	4	.	.	PUNCT
dti-1318	1104	1	tachedjian	tachedjian	NOUN
dti-1318	1104	2	,	,	PUNCT
dti-1318	1104	3	g.	g.	PROPN
dti-1318	1104	4	,	,	PUNCT
dti-1318	1104	5	aronson	aronson	PROPN
dti-1318	1104	6	,	,	PUNCT
dti-1318	1104	7	h.e	h.e	PROPN
dti-1318	1104	8	.	.	PROPN
dti-1318	1104	9	and	and	CCONJ
dti-1318	1104	10	goff	goff	PROPN
dti-1318	1104	11	,	,	PUNCT
dti-1318	1104	12	s.p	s.p	PROPN
dti-1318	1104	13	.	.	PROPN
dti-1318	1104	14	2000	2000	NUM
dti-1318	1104	15	.	.	PUNCT
dti-1318	1105	1	analysis	analysis	NOUN
dti-1318	1105	2	of	of	ADP
dti-1318	1105	3	mutations	mutation	NOUN
dti-1318	1105	4	and	and	CCONJ
dti-1318	1105	5	suppressors	suppressor	NOUN
dti-1318	1105	6	affecting	affect	VERB
dti-1318	1105	7	interactions	interaction	NOUN
dti-1318	1105	8	between	between	ADP
dti-1318	1105	9	the	the	DET
dti-1318	1105	10	subunits	subunit	NOUN
dti-1318	1105	11	of	of	ADP
dti-1318	1105	12	the	the	DET
dti-1318	1105	13	hiv	hiv	PROPN
dti-1318	1105	14	type	type	NOUN
dti-1318	1105	15	1	1	NUM
dti-1318	1105	16	reverse	reverse	NOUN
dti-1318	1105	17	transcriptase	transcriptase	NOUN
dti-1318	1105	18	.	.	PUNCT
dti-1318	1106	1	proc	proc	NOUN
dti-1318	1106	2	.	.	PUNCT
dti-1318	1107	1	natl	natl	PROPN
dti-1318	1107	2	.	.	PUNCT
dti-1318	1108	1	acad	acad	PROPN
dti-1318	1108	2	.	.	PUNCT
dti-1318	1109	1	sci	sci	PROPN
dti-1318	1109	2	.	.	PUNCT
dti-1318	1109	3	u.s.a	u.s.a	PROPN
dti-1318	1109	4	.	.	PROPN
dti-1318	1109	5	,	,	PUNCT
dti-1318	1109	6	97	97	NUM
dti-1318	1109	7	:	:	PUNCT
dti-1318	1109	8	6334–6339	6334–6339	NUM
dti-1318	1109	9	.	.	PUNCT
dti-1318	1110	1	tachedjian	tachedjian	NOUN
dti-1318	1110	2	,	,	PUNCT
dti-1318	1110	3	g.	g.	PROPN
dti-1318	1110	4	,	,	PUNCT
dti-1318	1110	5	moore	moore	PROPN
dti-1318	1110	6	,	,	PUNCT
dti-1318	1110	7	k.l	k.l	PROPN
dti-1318	1110	8	.	.	PROPN
dti-1318	1110	9	,	,	PUNCT
dti-1318	1110	10	goff	goff	PROPN
dti-1318	1110	11	,	,	PUNCT
dti-1318	1110	12	s.p	s.p	PROPN
dti-1318	1110	13	.	.	PROPN
dti-1318	1110	14	and	and	CCONJ
dti-1318	1110	15	sluis	sluis	NOUN
dti-1318	1110	16	-	-	PUNCT
dti-1318	1110	17	cremer	cremer	NOUN
dti-1318	1110	18	,	,	PUNCT
dti-1318	1110	19	n.	n.	PROPN
dti-1318	1110	20	2005a	2005a	NUM
dti-1318	1110	21	.	.	PUNCT
dti-1318	1111	1	efavirenz	efavirenz	PROPN
dti-1318	1111	2	enhances	enhance	VERB
dti-1318	1111	3	the	the	DET
dti-1318	1111	4	proteolytic	proteolytic	ADJ
dti-1318	1111	5	processing	processing	NOUN
dti-1318	1111	6	of	of	ADP
dti-1318	1111	7	an	an	DET
dti-1318	1111	8	hiv-1	hiv-1	ADJ
dti-1318	1111	9	pol	pol	NOUN
dti-1318	1111	10	polyprotein	polyprotein	ADJ
dti-1318	1111	11	precursor	precursor	NOUN
dti-1318	1111	12	and	and	CCONJ
dti-1318	1111	13	reverse	reverse	VERB
dti-1318	1111	14	transcriptase	transcriptase	NOUN
dti-1318	1111	15	homodimer	homodimer	NOUN
dti-1318	1111	16	formation	formation	NOUN
dti-1318	1111	17	.	.	PUNCT
dti-1318	1112	1	febs	febs	PROPN
dti-1318	1112	2	lett	lett	PROPN
dti-1318	1112	3	.	.	PROPN
dti-1318	1112	4	,	,	PUNCT
dti-1318	1112	5	579:379–384	579:379–384	NUM
dti-1318	1112	6	.	.	PUNCT
dti-1318	1113	1	tachedjian	tachedjian	NOUN
dti-1318	1113	2	,	,	PUNCT
dti-1318	1113	3	g.	g.	PROPN
dti-1318	1113	4	,	,	PUNCT
dti-1318	1113	5	orlova	orlova	PROPN
dti-1318	1113	6	,	,	PUNCT
dti-1318	1113	7	m.	m.	NOUN
dti-1318	1113	8	,	,	PUNCT
dti-1318	1113	9	sarafi	sarafi	PROPN
dti-1318	1113	10	anos	anos	PROPN
dti-1318	1113	11	,	,	PUNCT
dti-1318	1113	12	s.g	s.g	PROPN
dti-1318	1113	13	.	.	PROPN
dti-1318	1113	14	,	,	PUNCT
dti-1318	1113	15	arnold	arnold	PROPN
dti-1318	1113	16	,	,	PUNCT
dti-1318	1113	17	e.	e.	PROPN
dti-1318	1113	18	and	and	CCONJ
dti-1318	1113	19	goff	goff	PROPN
dti-1318	1113	20	,	,	PUNCT
dti-1318	1113	21	s.p	s.p	PROPN
dti-1318	1113	22	.	.	PROPN
dti-1318	1113	23	2001	2001	NUM
dti-1318	1113	24	.	.	PUNCT
dti-1318	1114	1	nonnucleoside	nonnucleoside	ADV
dti-1318	1114	2	reverse	reverse	ADJ
dti-1318	1114	3	transcriptase	transcriptase	NOUN
dti-1318	1114	4	inhibitors	inhibitor	NOUN
dti-1318	1114	5	are	be	AUX
dti-1318	1114	6	chemical	chemical	ADJ
dti-1318	1114	7	enhancers	enhancer	NOUN
dti-1318	1114	8	of	of	ADP
dti-1318	1114	9	dimerization	dimerization	NOUN
dti-1318	1114	10	of	of	ADP
dti-1318	1114	11	the	the	DET
dti-1318	1114	12	hiv	hiv	PROPN
dti-1318	1114	13	type	type	NOUN
dti-1318	1114	14	1	1	NUM
dti-1318	1114	15	reverse	reverse	NOUN
dti-1318	1114	16	transcriptase	transcriptase	NOUN
dti-1318	1114	17	.	.	PUNCT
dti-1318	1115	1	proc	proc	NOUN
dti-1318	1115	2	.	.	PUNCT
dti-1318	1116	1	natl	natl	PROPN
dti-1318	1116	2	.	.	PUNCT
dti-1318	1117	1	acad	acad	PROPN
dti-1318	1117	2	.	.	PUNCT
dti-1318	1118	1	sci	sci	PROPN
dti-1318	1118	2	.	.	PUNCT
dti-1318	1118	3	u.s.a	u.s.a	PROPN
dti-1318	1118	4	.	.	PROPN
dti-1318	1118	5	,	,	PUNCT
dti-1318	1118	6	98:7188–7193	98:7188–7193	NUM
dti-1318	1118	7	.	.	PUNCT
dti-1318	1119	1	tachedjian	tachedjian	NOUN
dti-1318	1119	2	,	,	PUNCT
dti-1318	1119	3	g.	g.	PROPN
dti-1318	1119	4	,	,	PUNCT
dti-1318	1119	5	radzio	radzio	PROPN
dti-1318	1119	6	,	,	PUNCT
dti-1318	1119	7	j.	j.	PROPN
dti-1318	1119	8	and	and	CCONJ
dti-1318	1119	9	sluis	sluis	NOUN
dti-1318	1119	10	-	-	PUNCT
dti-1318	1119	11	cremer	cremer	NOUN
dti-1318	1119	12	,	,	PUNCT
dti-1318	1119	13	n.	n.	PROPN
dti-1318	1119	14	2005b	2005b	NUM
dti-1318	1119	15	.	.	PUNCT
dti-1318	1120	1	relationship	relationship	NOUN
dti-1318	1120	2	between	between	ADP
dti-1318	1120	3	enzyme	enzyme	NOUN
dti-1318	1120	4	activity	activity	NOUN
dti-1318	1120	5	and	and	CCONJ
dti-1318	1120	6	dimeric	dimeric	ADJ
dti-1318	1120	7	structure	structure	NOUN
dti-1318	1120	8	of	of	ADP
dti-1318	1120	9	recombinant	recombinant	ADJ
dti-1318	1120	10	hiv-1	hiv-1	X
dti-1318	1120	11	reverse	reverse	ADJ
dti-1318	1120	12	transcriptase	transcriptase	NOUN
dti-1318	1120	13	.	.	PUNCT
dti-1318	1121	1	proteins	protein	NOUN
dti-1318	1121	2	,	,	PUNCT
dti-1318	1121	3	60:5–13	60:5–13	NOUN
dti-1318	1121	4	.	.	PUNCT
dti-1318	1122	1	tanchou	tanchou	NOUN
dti-1318	1122	2	,	,	PUNCT
dti-1318	1122	3	v.	v.	ADV
dti-1318	1122	4	,	,	PUNCT
dti-1318	1122	5	gabus	gabus	NOUN
dti-1318	1122	6	,	,	PUNCT
dti-1318	1122	7	c.	c.	PROPN
dti-1318	1122	8	,	,	PUNCT
dti-1318	1122	9	rogemond	rogemond	NOUN
dti-1318	1122	10	,	,	PUNCT
dti-1318	1122	11	v.	v.	NOUN
dti-1318	1122	12	and	and	CCONJ
dti-1318	1122	13	darlix	darlix	ADJ
dti-1318	1122	14	,	,	PUNCT
dti-1318	1122	15	j.l	j.l	PROPN
dti-1318	1122	16	.	.	PROPN
dti-1318	1122	17	1995	1995	NUM
dti-1318	1122	18	.	.	PUNCT
dti-1318	1123	1	formation	formation	NOUN
dti-1318	1123	2	of	of	ADP
dti-1318	1123	3	stable	stable	ADJ
dti-1318	1123	4	and	and	CCONJ
dti-1318	1123	5	functional	functional	ADJ
dti-1318	1123	6	hiv-1	hiv-1	X
dti-1318	1123	7	nucleoprotein	nucleoprotein	NOUN
dti-1318	1123	8	complexes	complex	NOUN
dti-1318	1123	9	in	in	ADP
dti-1318	1123	10	vitro	vitro	X
dti-1318	1123	11	.	.	PUNCT
dti-1318	1124	1	j.	j.	PROPN
dti-1318	1124	2	mol	mol	PROPN
dti-1318	1124	3	.	.	PUNCT
dti-1318	1125	1	biol	biol	PROPN
dti-1318	1125	2	.	.	PUNCT
dti-1318	1125	3	,	,	PUNCT
dti-1318	1125	4	252:563–571	252:563–571	NUM
dti-1318	1125	5	.	.	PUNCT
dti-1318	1125	6	tang	tang	PROPN
dti-1318	1125	7	,	,	PUNCT
dti-1318	1125	8	c.	c.	NOUN
dti-1318	1125	9	,	,	PUNCT
dti-1318	1125	10	loeliger	loeliger	NOUN
dti-1318	1125	11	,	,	PUNCT
dti-1318	1125	12	e.	e.	PROPN
dti-1318	1125	13	,	,	PUNCT
dti-1318	1125	14	kinde	kinde	PROPN
dti-1318	1125	15	,	,	PUNCT
dti-1318	1125	16	i.	i.	PROPN
dti-1318	1125	17	,	,	PUNCT
dti-1318	1125	18	kyere	kyere	PROPN
dti-1318	1125	19	,	,	PUNCT
dti-1318	1125	20	s.	s.	PROPN
dti-1318	1125	21	,	,	PUNCT
dti-1318	1125	22	mayo	mayo	NOUN
dti-1318	1125	23	,	,	PUNCT
dti-1318	1125	24	k.	k.	PROPN
dti-1318	1125	25	,	,	PUNCT
dti-1318	1125	26	barklis	barklis	PROPN
dti-1318	1125	27	,	,	PUNCT
dti-1318	1125	28	e.	e.	PROPN
dti-1318	1125	29	,	,	PUNCT
dti-1318	1125	30	sun	sun	PROPN
dti-1318	1125	31	,	,	PUNCT
dti-1318	1125	32	y.	y.	PROPN
dti-1318	1125	33	,	,	PUNCT
dti-1318	1125	34	huang	huang	PROPN
dti-1318	1125	35	,	,	PUNCT
dti-1318	1125	36	m.	m.	NOUN
dti-1318	1125	37	and	and	CCONJ
dti-1318	1125	38	summers	summer	NOUN
dti-1318	1125	39	,	,	PUNCT
dti-1318	1125	40	m.f	m.f	PROPN
dti-1318	1125	41	.	.	PROPN
dti-1318	1125	42	2003	2003	NUM
dti-1318	1125	43	.	.	PUNCT
dti-1318	1126	1	antiviral	antiviral	ADJ
dti-1318	1126	2	inhibition	inhibition	NOUN
dti-1318	1126	3	of	of	ADP
dti-1318	1126	4	the	the	DET
dti-1318	1126	5	hiv-1	hiv-1	X
dti-1318	1126	6	capsid	capsid	ADJ
dti-1318	1126	7	protein	protein	NOUN
dti-1318	1126	8	.	.	PUNCT
dti-1318	1127	1	j.	j.	PROPN
dti-1318	1127	2	mol	mol	PROPN
dti-1318	1127	3	.	.	PUNCT
dti-1318	1128	1	biol	biol	PROPN
dti-1318	1128	2	.	.	PUNCT
dti-1318	1128	3	,	,	PUNCT
dti-1318	1128	4	327:1013–1020	327:1013–1020	X
dti-1318	1128	5	.	.	X
dti-1318	1128	6	tang	tang	PROPN
dti-1318	1128	7	,	,	PUNCT
dti-1318	1128	8	c.	c.	NOUN
dti-1318	1128	9	,	,	PUNCT
dti-1318	1128	10	loeliger	loeliger	PROPN
dti-1318	1128	11	,	,	PUNCT
dti-1318	1128	12	e.	e.	PROPN
dti-1318	1128	13	,	,	PUNCT
dti-1318	1128	14	luncsford	luncsford	PROPN
dti-1318	1128	15	,	,	PUNCT
dti-1318	1128	16	p.	p.	PROPN
dti-1318	1128	17	,	,	PUNCT
dti-1318	1128	18	kinde	kinde	PROPN
dti-1318	1128	19	,	,	PUNCT
dti-1318	1128	20	i.	i.	PROPN
dti-1318	1128	21	,	,	PUNCT
dti-1318	1128	22	beckett	beckett	PROPN
dti-1318	1128	23	,	,	PUNCT
dti-1318	1128	24	d.	d.	PROPN
dti-1318	1128	25	and	and	CCONJ
dti-1318	1128	26	summers	summer	NOUN
dti-1318	1128	27	,	,	PUNCT
dti-1318	1128	28	m.f	m.f	PROPN
dti-1318	1128	29	.	.	PROPN
dti-1318	1128	30	2004	2004	NUM
dti-1318	1128	31	.	.	PUNCT
dti-1318	1129	1	entropic	entropic	ADJ
dti-1318	1129	2	switch	switch	NOUN
dti-1318	1129	3	regulates	regulate	VERB
dti-1318	1129	4	myristate	myristate	ADJ
dti-1318	1129	5	exposure	exposure	NOUN
dti-1318	1129	6	in	in	ADP
dti-1318	1129	7	the	the	DET
dti-1318	1129	8	hiv-1	hiv-1	X
dti-1318	1129	9	matrix	matrix	NOUN
dti-1318	1129	10	protein	protein	NOUN
dti-1318	1129	11	.	.	PUNCT
dti-1318	1130	1	proc	proc	PROPN
dti-1318	1130	2	.	.	PUNCT
dti-1318	1131	1	natl	natl	PROPN
dti-1318	1131	2	.	.	PUNCT
dti-1318	1132	1	acad	acad	PROPN
dti-1318	1132	2	.	.	PUNCT
dti-1318	1133	1	sci	sci	PROPN
dti-1318	1133	2	.	.	PUNCT
dti-1318	1133	3	u.s.a	u.s.a	PROPN
dti-1318	1133	4	.	.	PROPN
dti-1318	1133	5	,	,	PUNCT
dti-1318	1133	6	101:517–522	101:517–522	NUM
dti-1318	1133	7	.	.	PUNCT
dti-1318	1133	8	tang	tang	PROPN
dti-1318	1133	9	,	,	PUNCT
dti-1318	1133	10	c.	c.	PROPN
dti-1318	1133	11	,	,	PUNCT
dti-1318	1133	12	ndassa	ndassa	NOUN
dti-1318	1133	13	,	,	PUNCT
dti-1318	1133	14	y.	y.	PROPN
dti-1318	1133	15	and	and	CCONJ
dti-1318	1133	16	summers	summer	NOUN
dti-1318	1133	17	,	,	PUNCT
dti-1318	1133	18	m.f	m.f	PROPN
dti-1318	1133	19	.	.	PROPN
dti-1318	1133	20	2002	2002	NUM
dti-1318	1133	21	.	.	PUNCT
dti-1318	1134	1	structure	structure	NOUN
dti-1318	1134	2	of	of	ADP
dti-1318	1134	3	the	the	DET
dti-1318	1134	4	n	n	CCONJ
dti-1318	1134	5	-	-	PUNCT
dti-1318	1134	6	terminal	terminal	ADJ
dti-1318	1134	7	283	283	NUM
dti-1318	1134	8	-	-	PUNCT
dti-1318	1134	9	residue	residue	NOUN
dti-1318	1134	10	fragment	fragment	NOUN
dti-1318	1134	11	of	of	ADP
dti-1318	1134	12	the	the	DET
dti-1318	1134	13	immature	immature	ADJ
dti-1318	1134	14	hiv-1	hiv-1	X
dti-1318	1134	15	gag	gag	NOUN
dti-1318	1134	16	polyprotein	polyprotein	NOUN
dti-1318	1134	17	.	.	PUNCT
dti-1318	1135	1	nat	nat	PROPN
dti-1318	1135	2	.	.	PUNCT
dti-1318	1135	3	struct	struct	NOUN
dti-1318	1135	4	.	.	PUNCT
dti-1318	1136	1	biol	biol	PROPN
dti-1318	1136	2	.	.	PUNCT
dti-1318	1136	3	,	,	PUNCT
dti-1318	1137	1	9:537–543	9:537–543	PROPN
dti-1318	1137	2	.	.	PUNCT
dti-1318	1137	3	telesnitsky	telesnitsky	PROPN
dti-1318	1137	4	a.	a.	PROPN
dti-1318	1137	5	and	and	CCONJ
dti-1318	1137	6	goff	goff	PROPN
dti-1318	1137	7	,	,	PUNCT
dti-1318	1137	8	s.	s.	PROPN
dti-1318	1137	9	1997	1997	NUM
dti-1318	1137	10	.	.	PUNCT
dti-1318	1138	1	reverse	reverse	VERB
dti-1318	1138	2	transcriptase	transcriptase	NOUN
dti-1318	1138	3	and	and	CCONJ
dti-1318	1138	4	the	the	DET
dti-1318	1138	5	generation	generation	NOUN
dti-1318	1138	6	of	of	ADP
dti-1318	1138	7	retroviral	retroviral	ADJ
dti-1318	1138	8	dna	dna	NOUN
dti-1318	1138	9	.	.	PUNCT
dti-1318	1139	1	in	in	ADP
dti-1318	1139	2	coffi	coffi	PROPN
dti-1318	1139	3	n	n	CCONJ
dti-1318	1139	4	,	,	PUNCT
dti-1318	1139	5	j.m	j.m	PROPN
dti-1318	1139	6	.	.	PROPN
dti-1318	1139	7	,	,	PUNCT
dti-1318	1139	8	hughes	hughes	PROPN
dti-1318	1139	9	,	,	PUNCT
dti-1318	1139	10	s.	s.	PROPN
dti-1318	1139	11	h.	h.	PROPN
dti-1318	1139	12	and	and	CCONJ
dti-1318	1139	13	varmus	varmus	PROPN
dti-1318	1139	14	,	,	PUNCT
dti-1318	1139	15	h.e	h.e	PROPN
dti-1318	1139	16	.	.	PROPN
dti-1318	1139	17	(	(	PUNCT
dti-1318	1139	18	ed	ed	NOUN
dti-1318	1139	19	.	.	PUNCT
dti-1318	1139	20	)	)	PUNCT
dti-1318	1139	21	,	,	PUNCT
dti-1318	1139	22	retroviruses	retrovirus	NOUN
dti-1318	1139	23	.	.	PUNCT
dti-1318	1140	1	cold	cold	ADJ
dti-1318	1140	2	spring	spring	NOUN
dti-1318	1140	3	harbor	harbor	PROPN
dti-1318	1140	4	laboratory	laboratory	PROPN
dti-1318	1140	5	press	press	PROPN
dti-1318	1140	6	,	,	PUNCT
dti-1318	1140	7	new	new	PROPN
dti-1318	1140	8	york	york	PROPN
dti-1318	1140	9	.	.	PUNCT
dti-1318	1141	1	ternois	ternois	PROPN
dti-1318	1141	2	,	,	PUNCT
dti-1318	1141	3	f.	f.	PROPN
dti-1318	1141	4	,	,	PUNCT
dti-1318	1141	5	sticht	sticht	PROPN
dti-1318	1141	6	,	,	PUNCT
dti-1318	1141	7	j.	j.	PROPN
dti-1318	1141	8	,	,	PUNCT
dti-1318	1141	9	duquerroy	duquerroy	PROPN
dti-1318	1141	10	,	,	PUNCT
dti-1318	1141	11	s.	s.	PROPN
dti-1318	1141	12	,	,	PUNCT
dti-1318	1141	13	krausslich	krausslich	PROPN
dti-1318	1141	14	,	,	PUNCT
dti-1318	1141	15	h.g	h.g	X
dti-1318	1141	16	.	.	PROPN
dti-1318	1141	17	and	and	CCONJ
dti-1318	1141	18	rey	rey	PROPN
dti-1318	1141	19	,	,	PUNCT
dti-1318	1141	20	f.a	f.a	PROPN
dti-1318	1141	21	.	.	PROPN
dti-1318	1141	22	2005	2005	NUM
dti-1318	1141	23	.	.	PUNCT
dti-1318	1142	1	the	the	DET
dti-1318	1142	2	hiv-1	hiv-1	X
dti-1318	1142	3	capsid	capsid	ADJ
dti-1318	1142	4	protein	protein	NOUN
dti-1318	1142	5	c	c	NOUN
dti-1318	1142	6	-	-	PUNCT
dti-1318	1142	7	terminal	terminal	ADJ
dti-1318	1142	8	domain	domain	NOUN
dti-1318	1142	9	in	in	ADP
dti-1318	1142	10	complex	complex	NOUN
dti-1318	1142	11	with	with	ADP
dti-1318	1142	12	a	a	DET
dti-1318	1142	13	virus	virus	NOUN
dti-1318	1142	14	assembly	assembly	NOUN
dti-1318	1142	15	inhibitor	inhibitor	NOUN
dti-1318	1142	16	.	.	PUNCT
dti-1318	1143	1	nat	nat	PROPN
dti-1318	1143	2	.	.	PUNCT
dti-1318	1143	3	struct	struct	NOUN
dti-1318	1143	4	.	.	PUNCT
dti-1318	1144	1	mol	mol	PROPN
dti-1318	1144	2	.	.	PUNCT
dti-1318	1145	1	biol	biol	PROPN
dti-1318	1145	2	.	.	PUNCT
dti-1318	1145	3	,	,	PUNCT
dti-1318	1146	1	12:678–682	12:678–682	NUM
dti-1318	1146	2	.	.	PUNCT
dti-1318	1147	1	todd	todd	PROPN
dti-1318	1147	2	,	,	PUNCT
dti-1318	1147	3	m.j	m.j	PROPN
dti-1318	1147	4	.	.	PROPN
dti-1318	1147	5	,	,	PUNCT
dti-1318	1147	6	semo	semo	PROPN
dti-1318	1147	7	,	,	PUNCT
dti-1318	1147	8	n.	n.	NOUN
dti-1318	1147	9	and	and	CCONJ
dti-1318	1147	10	freire	freire	PROPN
dti-1318	1147	11	,	,	PUNCT
dti-1318	1147	12	e.	e.	PROPN
dti-1318	1147	13	1998	1998	NUM
dti-1318	1147	14	.	.	PUNCT
dti-1318	1148	1	the	the	DET
dti-1318	1148	2	structural	structural	ADJ
dti-1318	1148	3	stability	stability	NOUN
dti-1318	1148	4	of	of	ADP
dti-1318	1148	5	the	the	DET
dti-1318	1148	6	hiv-1	hiv-1	ADJ
dti-1318	1148	7	protease	protease	NOUN
dti-1318	1148	8	.	.	PUNCT
dti-1318	1149	1	j.	j.	PROPN
dti-1318	1149	2	mol	mol	PROPN
dti-1318	1149	3	.	.	PUNCT
dti-1318	1150	1	biol	biol	PROPN
dti-1318	1150	2	.	.	PUNCT
dti-1318	1150	3	,	,	PUNCT
dti-1318	1150	4	283:475–488	283:475–488	NUM
dti-1318	1150	5	.	.	PUNCT
dti-1318	1151	1	turpin	turpin	NOUN
dti-1318	1151	2	,	,	PUNCT
dti-1318	1151	3	j.a	j.a	PROPN
dti-1318	1151	4	.	.	PROPN
dti-1318	1151	5	,	,	PUNCT
dti-1318	1151	6	terpening	terpening	NOUN
dti-1318	1151	7	,	,	PUNCT
dti-1318	1151	8	s.j	s.j	PROPN
dti-1318	1151	9	.	.	PROPN
dti-1318	1151	10	,	,	PUNCT
dti-1318	1151	11	schaeffer	schaeffer	PROPN
dti-1318	1151	12	,	,	PUNCT
dti-1318	1151	13	c.a	c.a	PROPN
dti-1318	1151	14	.	.	PROPN
dti-1318	1151	15	,	,	PUNCT
dti-1318	1151	16	yu	yu	PROPN
dti-1318	1151	17	,	,	PUNCT
dti-1318	1151	18	g.	g.	PROPN
dti-1318	1151	19	,	,	PUNCT
dti-1318	1151	20	glover	glover	PROPN
dti-1318	1151	21	,	,	PUNCT
dti-1318	1151	22	c.j	c.j	PROPN
dti-1318	1151	23	.	.	PROPN
dti-1318	1151	24	,	,	PUNCT
dti-1318	1151	25	felsted	felste	VERB
dti-1318	1151	26	,	,	PUNCT
dti-1318	1151	27	r.l	r.l	PROPN
dti-1318	1151	28	.	.	PROPN
dti-1318	1151	29	,	,	PUNCT
dti-1318	1151	30	sausville	sausville	PROPN
dti-1318	1151	31	,	,	PUNCT
dti-1318	1151	32	e.a	e.a	PROPN
dti-1318	1151	33	.	.	PROPN
dti-1318	1151	34	and	and	CCONJ
dti-1318	1151	35	rice	rice	PROPN
dti-1318	1151	36	,	,	PUNCT
dti-1318	1151	37	w.g	w.g	PROPN
dti-1318	1151	38	.	.	PROPN
dti-1318	1151	39	1996	1996	NUM
dti-1318	1151	40	.	.	PUNCT
dti-1318	1152	1	inhibitors	inhibitor	NOUN
dti-1318	1152	2	of	of	ADP
dti-1318	1152	3	human	human	ADJ
dti-1318	1152	4	immunodefi	immunodefi	PROPN
dti-1318	1152	5	ciency	ciency	NOUN
dti-1318	1152	6	virus	virus	NOUN
dti-1318	1152	7	type	type	NOUN
dti-1318	1152	8	1	1	NUM
dti-1318	1152	9	zinc	zinc	NOUN
dti-1318	1152	10	fi	fi	NOUN
dti-1318	1152	11	ngers	nger	NOUN
dti-1318	1152	12	prevent	prevent	VERB
dti-1318	1152	13	normal	normal	ADJ
dti-1318	1152	14	processing	processing	NOUN
dti-1318	1152	15	of	of	ADP
dti-1318	1152	16	gag	gag	NOUN
dti-1318	1152	17	precursors	precursor	NOUN
dti-1318	1152	18	and	and	CCONJ
dti-1318	1152	19	result	result	VERB
dti-1318	1152	20	in	in	ADP
dti-1318	1152	21	the	the	DET
dti-1318	1152	22	release	release	NOUN
dti-1318	1152	23	of	of	ADP
dti-1318	1152	24	noninfectious	noninfectious	ADJ
dti-1318	1152	25	virus	virus	NOUN
dti-1318	1152	26	particles	particle	NOUN
dti-1318	1152	27	.	.	PUNCT
dti-1318	1153	1	j.	j.	PROPN
dti-1318	1153	2	virol	virol	PROPN
dti-1318	1153	3	.	.	PUNCT
dti-1318	1153	4	,	,	PUNCT
dti-1318	1154	1	70:6180–6189	70:6180–6189	X
dti-1318	1154	2	.	.	PUNCT
dti-1318	1155	1	uhlikova	uhlikova	PROPN
dti-1318	1155	2	,	,	PUNCT
dti-1318	1155	3	t.	t.	PROPN
dti-1318	1155	4	,	,	PUNCT
dti-1318	1155	5	konvalinka	konvalinka	PROPN
dti-1318	1155	6	,	,	PUNCT
dti-1318	1155	7	j.	j.	PROPN
dti-1318	1155	8	,	,	PUNCT
dti-1318	1155	9	pichova	pichova	PROPN
dti-1318	1155	10	,	,	PUNCT
dti-1318	1155	11	i.	i.	PROPN
dti-1318	1155	12	,	,	PUNCT
dti-1318	1155	13	soucek	soucek	NOUN
dti-1318	1155	14	,	,	PUNCT
dti-1318	1155	15	m.	m.	NOUN
dti-1318	1155	16	,	,	PUNCT
dti-1318	1155	17	krausslich	krausslich	PROPN
dti-1318	1155	18	,	,	PUNCT
dti-1318	1155	19	h.g	h.g	X
dti-1318	1155	20	.	.	PROPN
dti-1318	1155	21	and	and	CCONJ
dti-1318	1155	22	vondrasek	vondrasek	PROPN
dti-1318	1155	23	,	,	PUNCT
dti-1318	1155	24	j.	j.	PROPN
dti-1318	1155	25	1996	1996	NUM
dti-1318	1155	26	.	.	PUNCT
dti-1318	1156	1	a	a	DET
dti-1318	1156	2	modular	modular	ADJ
dti-1318	1156	3	approach	approach	NOUN
dti-1318	1156	4	to	to	ADP
dti-1318	1156	5	hiv-1	hiv-1	PUNCT
dti-1318	1156	6	proteinase	proteinase	NOUN
dti-1318	1156	7	inhibitor	inhibitor	NOUN
dti-1318	1156	8	design	design	NOUN
dti-1318	1156	9	.	.	PUNCT
dti-1318	1157	1	biochem	biochem	PROPN
dti-1318	1157	2	.	.	PUNCT
dti-1318	1158	1	biophys	biophy	NOUN
dti-1318	1158	2	.	.	PUNCT
dti-1318	1159	1	res	re	NOUN
dti-1318	1159	2	.	.	PUNCT
dti-1318	1160	1	commun	commun	PROPN
dti-1318	1160	2	.	.	PROPN
dti-1318	1160	3	,	,	PUNCT
dti-1318	1161	1	222:38–43	222:38–43	X
dti-1318	1161	2	.	.	PUNCT
dti-1318	1161	3	ulysse	ulysse	PROPN
dti-1318	1161	4	,	,	PUNCT
dti-1318	1161	5	l.g	l.g	PROPN
dti-1318	1161	6	.	.	PROPN
dti-1318	1161	7	and	and	CCONJ
dti-1318	1161	8	chmielewski	chmielewski	PROPN
dti-1318	1161	9	,	,	PUNCT
dti-1318	1161	10	j.	j.	PROPN
dti-1318	1161	11	1998	1998	NUM
dti-1318	1161	12	.	.	PUNCT
dti-1318	1162	1	restricting	restrict	VERB
dti-1318	1162	2	the	the	DET
dti-1318	1162	3	fl	fl	PROPN
dti-1318	1162	4	exibility	exibility	NOUN
dti-1318	1162	5	of	of	ADP
dti-1318	1162	6	crosslinked	crosslinke	VERB
dti-1318	1162	7	,	,	PUNCT
dti-1318	1162	8	interfacial	interfacial	ADJ
dti-1318	1162	9	peptide	peptide	NOUN
dti-1318	1162	10	inhibitors	inhibitor	NOUN
dti-1318	1162	11	of	of	ADP
dti-1318	1162	12	hiv-1	hiv-1	X
dti-1318	1162	13	protease	protease	NOUN
dti-1318	1162	14	.	.	PUNCT
dti-1318	1163	1	bioorg	bioorg	PROPN
dti-1318	1163	2	.	.	PUNCT
dti-1318	1164	1	med	med	PROPN
dti-1318	1164	2	.	.	PROPN
dti-1318	1164	3	chem	chem	PROPN
dti-1318	1164	4	.	.	PUNCT
dti-1318	1165	1	lett	lett	PROPN
dti-1318	1165	2	.	.	PROPN
dti-1318	1165	3	,	,	PUNCT
dti-1318	1165	4	8:3281–3286	8:3281–3286	NUM
dti-1318	1165	5	.	.	PUNCT
dti-1318	1166	1	venezia	venezia	PROPN
dti-1318	1166	2	,	,	PUNCT
dti-1318	1166	3	c.f	c.f	PROPN
dti-1318	1166	4	.	.	PROPN
dti-1318	1166	5	,	,	PUNCT
dti-1318	1166	6	howard	howard	PROPN
dti-1318	1166	7	,	,	PUNCT
dti-1318	1166	8	k.j	k.j	PROPN
dti-1318	1166	9	.	.	PROPN
dti-1318	1166	10	,	,	PUNCT
dti-1318	1166	11	ignatov	ignatov	PROPN
dti-1318	1166	12	,	,	PUNCT
dti-1318	1166	13	m.e	m.e	PROPN
dti-1318	1166	14	.	.	PROPN
dti-1318	1166	15	,	,	PUNCT
dti-1318	1166	16	holladay	holladay	PROPN
dti-1318	1166	17	,	,	PUNCT
dti-1318	1166	18	l.a	l.a	PROPN
dti-1318	1166	19	.	.	PROPN
dti-1318	1166	20	and	and	CCONJ
dti-1318	1166	21	barkley	barkley	PROPN
dti-1318	1166	22	,	,	PUNCT
dti-1318	1166	23	m.d	m.d	PROPN
dti-1318	1166	24	.	.	PROPN
dti-1318	1166	25	2006	2006	NUM
dti-1318	1166	26	.	.	PUNCT
dti-1318	1167	1	effects	effect	NOUN
dti-1318	1167	2	of	of	ADP
dti-1318	1167	3	efavirenz	efavirenz	NOUN
dti-1318	1167	4	binding	bind	VERB
dti-1318	1167	5	on	on	ADP
dti-1318	1167	6	the	the	DET
dti-1318	1167	7	subunit	subunit	NOUN
dti-1318	1167	8	equilibria	equilibrium	NOUN
dti-1318	1167	9	of	of	ADP
dti-1318	1167	10	hiv-1	hiv-1	X
dti-1318	1167	11	reverse	reverse	ADJ
dti-1318	1167	12	transcriptase	transcriptase	NOUN
dti-1318	1167	13	.	.	PUNCT
dti-1318	1168	1	biochemistry	biochemistry	NOUN
dti-1318	1168	2	,	,	PUNCT
dti-1318	1168	3	45:2779–2789	45:2779–2789	NUM
dti-1318	1168	4	.	.	PUNCT
dti-1318	1169	1	veronese	veronese	PROPN
dti-1318	1169	2	,	,	PUNCT
dti-1318	1169	3	f.d	f.d	PROPN
dti-1318	1169	4	.	.	PROPN
dti-1318	1169	5	,	,	PUNCT
dti-1318	1169	6	copeland	copeland	PROPN
dti-1318	1169	7	,	,	PUNCT
dti-1318	1169	8	t.d	t.d	PROPN
dti-1318	1169	9	.	.	PROPN
dti-1318	1169	10	,	,	PUNCT
dti-1318	1169	11	oroszlan	oroszlan	PROPN
dti-1318	1169	12	,	,	PUNCT
dti-1318	1169	13	s.	s.	PROPN
dti-1318	1169	14	,	,	PUNCT
dti-1318	1169	15	gallo	gallo	PROPN
dti-1318	1169	16	,	,	PUNCT
dti-1318	1169	17	r.c	r.c	PROPN
dti-1318	1169	18	.	.	PROPN
dti-1318	1169	19	and	and	CCONJ
dti-1318	1169	20	sarngadharan	sarngadharan	PROPN
dti-1318	1169	21	,	,	PUNCT
dti-1318	1169	22	m.g	m.g	PROPN
dti-1318	1169	23	.	.	PROPN
dti-1318	1169	24	1988	1988	NUM
dti-1318	1169	25	.	.	PUNCT
dti-1318	1170	1	biochemical	biochemical	ADJ
dti-1318	1170	2	and	and	CCONJ
dti-1318	1170	3	immunological	immunological	ADJ
dti-1318	1170	4	analysis	analysis	NOUN
dti-1318	1170	5	of	of	ADP
dti-1318	1170	6	human	human	ADJ
dti-1318	1170	7	immunodefi	immunodefi	PROPN
dti-1318	1170	8	ciency	ciency	NOUN
dti-1318	1170	9	virus	virus	NOUN
dti-1318	1170	10	gag	gag	NOUN
dti-1318	1170	11	gene	gene	NOUN
dti-1318	1170	12	products	product	NOUN
dti-1318	1170	13	p17	p17	NOUN
dti-1318	1170	14	and	and	CCONJ
dti-1318	1170	15	p24	p24	NOUN
dti-1318	1170	16	.	.	PUNCT
dti-1318	1171	1	j.	j.	PROPN
dti-1318	1171	2	virol	virol	PROPN
dti-1318	1171	3	.	.	PUNCT
dti-1318	1171	4	,	,	PUNCT
dti-1318	1171	5	62	62	NUM
dti-1318	1171	6	:	:	PUNCT
dti-1318	1171	7	795–801	795–801	NUM
dti-1318	1171	8	.	.	PUNCT
dti-1318	1172	1	verplank	verplank	PROPN
dti-1318	1172	2	,	,	PUNCT
dti-1318	1172	3	l.	l.	PROPN
dti-1318	1172	4	,	,	PUNCT
dti-1318	1172	5	bouamr	bouamr	NOUN
dti-1318	1172	6	,	,	PUNCT
dti-1318	1172	7	f.	f.	PROPN
dti-1318	1172	8	,	,	PUNCT
dti-1318	1172	9	lagrassa	lagrassa	PROPN
dti-1318	1172	10	,	,	PUNCT
dti-1318	1172	11	t.j	t.j	PROPN
dti-1318	1172	12	.	.	PROPN
dti-1318	1172	13	,	,	PUNCT
dti-1318	1172	14	agresta	agresta	PROPN
dti-1318	1172	15	,	,	PUNCT
dti-1318	1172	16	b.	b.	PROPN
dti-1318	1172	17	,	,	PUNCT
dti-1318	1172	18	kikonyogo	kikonyogo	PROPN
dti-1318	1172	19	,	,	PUNCT
dti-1318	1172	20	a.	a.	NOUN
dti-1318	1172	21	,	,	PUNCT
dti-1318	1172	22	leis	leis	NOUN
dti-1318	1172	23	,	,	PUNCT
dti-1318	1172	24	j.	j.	PROPN
dti-1318	1172	25	and	and	CCONJ
dti-1318	1172	26	carter	carter	PROPN
dti-1318	1172	27	,	,	PUNCT
dti-1318	1172	28	c.a	c.a	PROPN
dti-1318	1172	29	.	.	PROPN
dti-1318	1172	30	2001	2001	NUM
dti-1318	1172	31	.	.	PUNCT
dti-1318	1173	1	tsg101	tsg101	PROPN
dti-1318	1173	2	,	,	PUNCT
dti-1318	1173	3	a	a	DET
dti-1318	1173	4	homologue	homologue	NOUN
dti-1318	1173	5	of	of	ADP
dti-1318	1173	6	ubiquitin	ubiquitin	NOUN
dti-1318	1173	7	-	-	PUNCT
dti-1318	1173	8	conjugating	conjugate	VERB
dti-1318	1173	9	(	(	PUNCT
dti-1318	1173	10	e2	e2	PROPN
dti-1318	1173	11	)	)	PUNCT
dti-1318	1173	12	enzymes	enzyme	NOUN
dti-1318	1173	13	,	,	PUNCT
dti-1318	1173	14	binds	bind	VERB
dti-1318	1173	15	the	the	DET
dti-1318	1173	16	l	l	NOUN
dti-1318	1173	17	domain	domain	NOUN
dti-1318	1173	18	in	in	ADP
dti-1318	1173	19	hiv	hiv	PROPN
dti-1318	1173	20	type	type	NOUN
dti-1318	1173	21	1	1	NUM
dti-1318	1173	22	pr55(gag	pr55(gag	NOUN
dti-1318	1173	23	)	)	PUNCT
dti-1318	1173	24	.	.	PUNCT
dti-1318	1174	1	proc	proc	PROPN
dti-1318	1174	2	.	.	PUNCT
dti-1318	1175	1	natl	natl	PROPN
dti-1318	1175	2	.	.	PUNCT
dti-1318	1176	1	acad	acad	PROPN
dti-1318	1176	2	.	.	PUNCT
dti-1318	1177	1	sci	sci	PROPN
dti-1318	1177	2	.	.	PROPN
dti-1318	1177	3	,	,	PUNCT
dti-1318	1177	4	u.s.a	u.s.a	PROPN
dti-1318	1177	5	.	.	PROPN
dti-1318	1177	6	,	,	PUNCT
dti-1318	1177	7	98	98	NUM
dti-1318	1177	8	:	:	PUNCT
dti-1318	1177	9	7724–7729	7724–7729	NUM
dti-1318	1177	10	.	.	PUNCT
dti-1318	1178	1	vivet	vivet	NOUN
dti-1318	1178	2	-	-	PUNCT
dti-1318	1178	3	boudou	boudou	NOUN
dti-1318	1178	4	,	,	PUNCT
dti-1318	1178	5	v.	v.	ADV
dti-1318	1178	6	,	,	PUNCT
dti-1318	1178	7	didierjean	didierjean	PROPN
dti-1318	1178	8	,	,	PUNCT
dti-1318	1178	9	j.	j.	PROPN
dti-1318	1178	10	,	,	PUNCT
dti-1318	1178	11	isel	isel	PROPN
dti-1318	1178	12	,	,	PUNCT
dti-1318	1178	13	c.	c.	NOUN
dti-1318	1178	14	and	and	CCONJ
dti-1318	1178	15	marquet	marquet	PROPN
dti-1318	1178	16	,	,	PUNCT
dti-1318	1178	17	r.	r.	PROPN
dti-1318	1178	18	2006	2006	NUM
dti-1318	1178	19	.	.	PUNCT
dti-1318	1179	1	nucleoside	nucleoside	VERB
dti-1318	1179	2	and	and	CCONJ
dti-1318	1179	3	nucleotide	nucleotide	ADJ
dti-1318	1179	4	inhibitors	inhibitor	NOUN
dti-1318	1179	5	of	of	ADP
dti-1318	1179	6	hiv-1	hiv-1	X
dti-1318	1179	7	replication	replication	NOUN
dti-1318	1179	8	.	.	PUNCT
dti-1318	1180	1	cell	cell	NOUN
dti-1318	1180	2	.	.	PUNCT
dti-1318	1181	1	mol	mol	PROPN
dti-1318	1181	2	.	.	PROPN
dti-1318	1181	3	life	life	NOUN
dti-1318	1181	4	.	.	PUNCT
dti-1318	1182	1	sci	sci	PROPN
dti-1318	1182	2	.	.	PROPN
dti-1318	1182	3	,	,	PUNCT
dti-1318	1183	1	63:163–186	63:163–186	PROPN
dti-1318	1183	2	.	.	PUNCT
dti-1318	1184	1	vogt	vogt	PROPN
dti-1318	1184	2	,	,	PUNCT
dti-1318	1184	3	v.m	v.m	PROPN
dti-1318	1184	4	.	.	PROPN
dti-1318	1184	5	1996	1996	NUM
dti-1318	1184	6	.	.	PUNCT
dti-1318	1185	1	proteolytic	proteolytic	ADJ
dti-1318	1185	2	processing	processing	NOUN
dti-1318	1185	3	and	and	CCONJ
dti-1318	1185	4	particle	particle	NOUN
dti-1318	1185	5	maturation	maturation	NOUN
dti-1318	1185	6	.	.	PUNCT
dti-1318	1186	1	curr	curr	PROPN
dti-1318	1186	2	.	.	PUNCT
dti-1318	1186	3	top	top	PROPN
dti-1318	1186	4	.	.	PUNCT
dti-1318	1187	1	microbiol	microbiol	PROPN
dti-1318	1187	2	.	.	PUNCT
dti-1318	1188	1	immunol	immunol	PROPN
dti-1318	1188	2	.	.	PUNCT
dti-1318	1188	3	,	,	PUNCT
dti-1318	1188	4	214:95–131	214:95–131	NUM
dti-1318	1188	5	.	.	PUNCT
dti-1318	1188	6	von	von	PROPN
dti-1318	1188	7	schwedler	schwedler	PROPN
dti-1318	1188	8	,	,	PUNCT
dti-1318	1188	9	u.k	u.k	PROPN
dti-1318	1188	10	.	.	PROPN
dti-1318	1188	11	,	,	PUNCT
dti-1318	1188	12	stray	stray	VERB
dti-1318	1188	13	,	,	PUNCT
dti-1318	1188	14	k.m	k.m	PROPN
dti-1318	1188	15	.	.	PROPN
dti-1318	1188	16	,	,	PUNCT
dti-1318	1188	17	garrus	garrus	PROPN
dti-1318	1188	18	,	,	PUNCT
dti-1318	1188	19	j.e	j.e	PROPN
dti-1318	1188	20	.	.	PROPN
dti-1318	1188	21	and	and	CCONJ
dti-1318	1188	22	sundquist	sundquist	PROPN
dti-1318	1188	23	,	,	PUNCT
dti-1318	1188	24	w.i	w.i	PROPN
dti-1318	1188	25	.	.	PROPN
dti-1318	1188	26	2003	2003	NUM
dti-1318	1188	27	.	.	PUNCT
dti-1318	1189	1	functional	functional	ADJ
dti-1318	1189	2	surfaces	surface	NOUN
dti-1318	1189	3	of	of	ADP
dti-1318	1189	4	the	the	DET
dti-1318	1189	5	human	human	ADJ
dti-1318	1189	6	immunodefi	immunodefi	PROPN
dti-1318	1189	7	ciency	ciency	NOUN
dti-1318	1189	8	virus	virus	NOUN
dti-1318	1189	9	type	type	NOUN
dti-1318	1189	10	1	1	NUM
dti-1318	1189	11	capsid	capsid	NOUN
dti-1318	1189	12	protein	protein	NOUN
dti-1318	1189	13	.	.	PUNCT
dti-1318	1190	1	j.	j.	PROPN
dti-1318	1190	2	virol	virol	PROPN
dti-1318	1190	3	.	.	PUNCT
dti-1318	1190	4	,	,	PUNCT
dti-1318	1190	5	77:5439–5450	77:5439–5450	NOUN
dti-1318	1190	6	.	.	PUNCT
dti-1318	1191	1	wapling	waple	VERB
dti-1318	1191	2	,	,	PUNCT
dti-1318	1191	3	j.	j.	PROPN
dti-1318	1191	4	,	,	PUNCT
dti-1318	1191	5	moore	moore	PROPN
dti-1318	1191	6	,	,	PUNCT
dti-1318	1191	7	k.l	k.l	PROPN
dti-1318	1191	8	.	.	PROPN
dti-1318	1191	9	,	,	PUNCT
dti-1318	1191	10	sonza	sonza	PROPN
dti-1318	1191	11	,	,	PUNCT
dti-1318	1191	12	s.	s.	PROPN
dti-1318	1191	13	,	,	PUNCT
dti-1318	1191	14	mak	mak	PROPN
dti-1318	1191	15	,	,	PUNCT
dti-1318	1191	16	j.	j.	PROPN
dti-1318	1191	17	and	and	CCONJ
dti-1318	1191	18	tachedjian	tachedjian	PROPN
dti-1318	1191	19	,	,	PUNCT
dti-1318	1191	20	g.	g.	PROPN
dti-1318	1191	21	2005	2005	NUM
dti-1318	1191	22	.	.	PUNCT
dti-1318	1192	1	mutations	mutation	NOUN
dti-1318	1192	2	that	that	PRON
dti-1318	1192	3	abrogate	abrogate	VERB
dti-1318	1192	4	human	human	ADJ
dti-1318	1192	5	immunodefi	immunodefi	PROPN
dti-1318	1192	6	ciency	ciency	NOUN
dti-1318	1192	7	virus	virus	NOUN
dti-1318	1192	8	type	type	NOUN
dti-1318	1192	9	1	1	NUM
dti-1318	1192	10	reverse	reverse	NOUN
dti-1318	1192	11	transcriptase	transcriptase	NOUN
dti-1318	1192	12	dimerization	dimerization	NOUN
dti-1318	1192	13	affect	affect	VERB
dti-1318	1192	14	maturation	maturation	NOUN
dti-1318	1192	15	of	of	ADP
dti-1318	1192	16	the	the	DET
dti-1318	1192	17	reverse	reverse	ADJ
dti-1318	1192	18	transcriptase	transcriptase	NOUN
dti-1318	1192	19	heterodimer	heterodimer	NOUN
dti-1318	1192	20	.	.	PUNCT
dti-1318	1193	1	j.	j.	PROPN
dti-1318	1193	2	virol	virol	PROPN
dti-1318	1193	3	.	.	PUNCT
dti-1318	1193	4	,	,	PUNCT
dti-1318	1193	5	79:10247–10257	79:10247–10257	PROPN
dti-1318	1193	6	.	.	PUNCT
dti-1318	1194	1	wei	wei	PROPN
dti-1318	1194	2	,	,	PUNCT
dti-1318	1194	3	b.l	b.l	PROPN
dti-1318	1194	4	.	.	PROPN
dti-1318	1194	5	,	,	PUNCT
dti-1318	1194	6	denton	denton	PROPN
dti-1318	1194	7	,	,	PUNCT
dti-1318	1194	8	p.w	p.w	PROPN
dti-1318	1194	9	.	.	PROPN
dti-1318	1194	10	,	,	PUNCT
dti-1318	1194	11	o’neill	o’neill	PROPN
dti-1318	1194	12	,	,	PUNCT
dti-1318	1194	13	e.	e.	PROPN
dti-1318	1194	14	,	,	PUNCT
dti-1318	1194	15	luo	luo	PROPN
dti-1318	1194	16	,	,	PUNCT
dti-1318	1194	17	t.	t.	PROPN
dti-1318	1194	18	,	,	PUNCT
dti-1318	1194	19	foster	foster	PROPN
dti-1318	1194	20	,	,	PUNCT
dti-1318	1194	21	j.l	j.l	PROPN
dti-1318	1194	22	.	.	PROPN
dti-1318	1194	23	and	and	CCONJ
dti-1318	1194	24	garcia	garcia	PROPN
dti-1318	1194	25	,	,	PUNCT
dti-1318	1194	26	j.v	j.v	PROPN
dti-1318	1194	27	.	.	PROPN
dti-1318	1194	28	2005	2005	NUM
dti-1318	1194	29	.	.	PUNCT
dti-1318	1195	1	inhibition	inhibition	NOUN
dti-1318	1195	2	of	of	ADP
dti-1318	1195	3	lysosome	lysosome	NOUN
dti-1318	1195	4	and	and	CCONJ
dti-1318	1195	5	proteasome	proteasome	NOUN
dti-1318	1195	6	function	function	NOUN
dti-1318	1195	7	enhances	enhance	VERB
dti-1318	1195	8	human	human	ADJ
dti-1318	1195	9	immunodeficiency	immunodeficiency	NOUN
dti-1318	1195	10	virus	virus	NOUN
dti-1318	1195	11	type	type	NOUN
dti-1318	1195	12	1	1	NUM
dti-1318	1195	13	infection	infection	NOUN
dti-1318	1195	14	.	.	PUNCT
dti-1318	1196	1	j.	j.	PROPN
dti-1318	1196	2	virol	virol	PROPN
dti-1318	1196	3	.	.	PUNCT
dti-1318	1196	4	,	,	PUNCT
dti-1318	1196	5	79	79	NUM
dti-1318	1196	6	:	:	PUNCT
dti-1318	1196	7	5705–5712	5705–5712	NOUN
dti-1318	1196	8	.	.	PUNCT
dti-1318	1197	1	wiegers	wieger	NOUN
dti-1318	1197	2	,	,	PUNCT
dti-1318	1197	3	k.	k.	PROPN
dti-1318	1197	4	,	,	PUNCT
dti-1318	1197	5	rutter	rutter	PROPN
dti-1318	1197	6	,	,	PUNCT
dti-1318	1197	7	g.	g.	PROPN
dti-1318	1197	8	,	,	PUNCT
dti-1318	1197	9	kottler	kottler	PROPN
dti-1318	1197	10	,	,	PUNCT
dti-1318	1197	11	h.	h.	PROPN
dti-1318	1197	12	,	,	PUNCT
dti-1318	1197	13	tessmer	tessmer	NOUN
dti-1318	1197	14	,	,	PUNCT
dti-1318	1197	15	u.	u.	PROPN
dti-1318	1197	16	,	,	PUNCT
dti-1318	1197	17	hohenberg	hohenberg	PROPN
dti-1318	1197	18	,	,	PUNCT
dti-1318	1197	19	h.	h.	PROPN
dti-1318	1197	20	and	and	CCONJ
dti-1318	1197	21	krausslich	krausslich	PROPN
dti-1318	1197	22	,	,	PUNCT
dti-1318	1197	23	h.g	h.g	PROPN
dti-1318	1197	24	.	.	PROPN
dti-1318	1197	25	1998	1998	NUM
dti-1318	1197	26	.	.	PUNCT
dti-1318	1198	1	sequential	sequential	ADJ
dti-1318	1198	2	steps	step	NOUN
dti-1318	1198	3	in	in	ADP
dti-1318	1198	4	human	human	ADJ
dti-1318	1198	5	immunodefi	immunodefi	PROPN
dti-1318	1198	6	ciency	ciency	NOUN
dti-1318	1198	7	virus	virus	NOUN
dti-1318	1198	8	particle	particle	NOUN
dti-1318	1198	9	maturation	maturation	NOUN
dti-1318	1198	10	revealed	reveal	VERB
dti-1318	1198	11	by	by	ADP
dti-1318	1198	12	alterations	alteration	NOUN
dti-1318	1198	13	of	of	ADP
dti-1318	1198	14	individual	individual	ADJ
dti-1318	1198	15	gag	gag	NOUN
dti-1318	1198	16	polyprotein	polyprotein	ADJ
dti-1318	1198	17	cleavage	cleavage	NOUN
dti-1318	1198	18	sites	site	NOUN
dti-1318	1198	19	.	.	PUNCT
dti-1318	1199	1	j.	j.	PROPN
dti-1318	1199	2	virol	virol	PROPN
dti-1318	1199	3	.	.	PUNCT
dti-1318	1199	4	,	,	PUNCT
dti-1318	1199	5	72:2846–2854	72:2846–2854	X
dti-1318	1199	6	.	.	PUNCT
dti-1318	1200	1	willey	willey	PROPN
dti-1318	1200	2	,	,	PUNCT
dti-1318	1200	3	r.l	r.l	PROPN
dti-1318	1200	4	.	.	PROPN
dti-1318	1200	5	,	,	PUNCT
dti-1318	1200	6	maldarelli	maldarelli	PROPN
dti-1318	1200	7	,	,	PUNCT
dti-1318	1200	8	f.	f.	PROPN
dti-1318	1200	9	,	,	PUNCT
dti-1318	1200	10	martin	martin	PROPN
dti-1318	1200	11	,	,	PUNCT
dti-1318	1200	12	m.a	m.a	PROPN
dti-1318	1200	13	.	.	PROPN
dti-1318	1200	14	and	and	CCONJ
dti-1318	1200	15	strebel	strebel	NOUN
dti-1318	1200	16	,	,	PUNCT
dti-1318	1200	17	k.	k.	PROPN
dti-1318	1200	18	1992	1992	NUM
dti-1318	1200	19	.	.	PUNCT
dti-1318	1201	1	human	human	ADJ
dti-1318	1201	2	immunodefi	immunodefi	PROPN
dti-1318	1201	3	ciency	ciency	NOUN
dti-1318	1201	4	virus	virus	NOUN
dti-1318	1201	5	type	type	NOUN
dti-1318	1201	6	1	1	NUM
dti-1318	1201	7	vpu	vpu	NOUN
dti-1318	1201	8	protein	protein	NOUN
dti-1318	1201	9	induces	induce	VERB
dti-1318	1201	10	rapid	rapid	ADJ
dti-1318	1201	11	degradation	degradation	NOUN
dti-1318	1201	12	of	of	ADP
dti-1318	1201	13	cd4	cd4	PROPN
dti-1318	1201	14	.	.	PUNCT
dti-1318	1202	1	j.	j.	PROPN
dti-1318	1202	2	virol	virol	PROPN
dti-1318	1202	3	,	,	PUNCT
dti-1318	1202	4	66:7193–7200	66:7193–7200	NUM
dti-1318	1202	5	.	.	PUNCT
dti-1318	1203	1	wlodawer	wlodawer	NOUN
dti-1318	1203	2	,	,	PUNCT
dti-1318	1203	3	a.	a.	NOUN
dti-1318	1203	4	,	,	PUNCT
dti-1318	1203	5	miller	miller	PROPN
dti-1318	1203	6	,	,	PUNCT
dti-1318	1203	7	m.	m.	NOUN
dti-1318	1203	8	,	,	PUNCT
dti-1318	1203	9	jaskolski	jaskolski	ADJ
dti-1318	1203	10	,	,	PUNCT
dti-1318	1203	11	m.	m.	NOUN
dti-1318	1203	12	,	,	PUNCT
dti-1318	1203	13	sathyanarayana	sathyanarayana	PROPN
dti-1318	1203	14	,	,	PUNCT
dti-1318	1203	15	b.k	b.k	PROPN
dti-1318	1203	16	.	.	PROPN
dti-1318	1203	17	,	,	PUNCT
dti-1318	1203	18	baldwin	baldwin	PROPN
dti-1318	1203	19	,	,	PUNCT
dti-1318	1203	20	e.	e.	PROPN
dti-1318	1203	21	,	,	PUNCT
dti-1318	1203	22	weber	weber	PROPN
dti-1318	1203	23	,	,	PUNCT
dti-1318	1203	24	i.t	i.t	PROPN
dti-1318	1203	25	.	.	PROPN
dti-1318	1203	26	,	,	PUNCT
dti-1318	1203	27	selk	selk	PROPN
dti-1318	1203	28	,	,	PUNCT
dti-1318	1203	29	l.m	l.m	PROPN
dti-1318	1203	30	.	.	PROPN
dti-1318	1203	31	,	,	PUNCT
dti-1318	1203	32	clawson	clawson	PROPN
dti-1318	1203	33	,	,	PUNCT
dti-1318	1203	34	l.	l.	PROPN
dti-1318	1203	35	,	,	PUNCT
dti-1318	1203	36	schneider	schneider	PROPN
dti-1318	1203	37	,	,	PUNCT
dti-1318	1203	38	j.	j.	PROPN
dti-1318	1203	39	and	and	CCONJ
dti-1318	1203	40	kent	kent	PROPN
dti-1318	1203	41	,	,	PUNCT
dti-1318	1203	42	s.b	s.b	PROPN
dti-1318	1203	43	.	.	PROPN
dti-1318	1203	44	1989	1989	NUM
dti-1318	1203	45	.	.	PUNCT
dti-1318	1204	1	conserved	conserve	VERB
dti-1318	1204	2	folding	fold	VERB
dti-1318	1204	3	in	in	ADP
dti-1318	1204	4	retroviral	retroviral	ADJ
dti-1318	1204	5	proteases	protease	NOUN
dti-1318	1204	6	:	:	PUNCT
dti-1318	1204	7	crystal	crystal	NOUN
dti-1318	1204	8	structure	structure	NOUN
dti-1318	1204	9	of	of	ADP
dti-1318	1204	10	a	a	DET
dti-1318	1204	11	synthetic	synthetic	ADJ
dti-1318	1204	12	hiv-1	hiv-1	ADJ
dti-1318	1204	13	protease	protease	NOUN
dti-1318	1204	14	.	.	PUNCT
dti-1318	1205	1	science	science	NOUN
dti-1318	1205	2	,	,	PUNCT
dti-1318	1205	3	245:616–621	245:616–621	NUM
dti-1318	1205	4	.	.	PUNCT
dti-1318	1206	1	worthylake	worthylake	NOUN
dti-1318	1206	2	,	,	PUNCT
dti-1318	1206	3	d.k	d.k	PROPN
dti-1318	1206	4	.	.	PROPN
dti-1318	1206	5	,	,	PUNCT
dti-1318	1206	6	wang	wang	PROPN
dti-1318	1206	7	,	,	PUNCT
dti-1318	1206	8	h.	h.	PROPN
dti-1318	1206	9	,	,	PUNCT
dti-1318	1206	10	yoo	yoo	PROPN
dti-1318	1206	11	,	,	PUNCT
dti-1318	1206	12	s.	s.	PROPN
dti-1318	1206	13	,	,	PUNCT
dti-1318	1206	14	sundquist	sundquist	PROPN
dti-1318	1206	15	,	,	PUNCT
dti-1318	1206	16	w.i	w.i	PROPN
dti-1318	1206	17	.	.	PROPN
dti-1318	1206	18	and	and	CCONJ
dti-1318	1206	19	hill	hill	PROPN
dti-1318	1206	20	,	,	PUNCT
dti-1318	1206	21	c.p	c.p	PROPN
dti-1318	1206	22	.	.	PROPN
dti-1318	1206	23	1999	1999	NUM
dti-1318	1206	24	.	.	PUNCT
dti-1318	1207	1	structures	structure	NOUN
dti-1318	1207	2	of	of	ADP
dti-1318	1207	3	the	the	DET
dti-1318	1207	4	hiv-1	hiv-1	X
dti-1318	1207	5	capsid	capsid	ADJ
dti-1318	1207	6	protein	protein	NOUN
dti-1318	1207	7	dimerization	dimerization	NOUN
dti-1318	1207	8	domain	domain	NOUN
dti-1318	1207	9	at	at	ADP
dti-1318	1207	10	2.6	2.6	NUM
dti-1318	1207	11	a	a	DET
dti-1318	1207	12	resolution	resolution	NOUN
dti-1318	1207	13	.	.	PUNCT
dti-1318	1208	1	acta	acta	PROPN
dti-1318	1208	2	.	.	PUNCT
dti-1318	1209	1	crystallogr	crystallogr	PROPN
dti-1318	1209	2	.	.	PUNCT
dti-1318	1210	1	d.	d.	PROPN
dti-1318	1210	2	biol	biol	PROPN
dti-1318	1210	3	.	.	PUNCT
dti-1318	1211	1	crystallogr	crystallogr	PROPN
dti-1318	1211	2	.	.	PUNCT
dti-1318	1211	3	,	,	PUNCT
dti-1318	1211	4	55:85–92	55:85–92	NUM
dti-1318	1211	5	.	.	PUNCT
dti-1318	1212	1	wu	wu	PROPN
dti-1318	1212	2	,	,	PUNCT
dti-1318	1212	3	x.	x.	PROPN
dti-1318	1212	4	,	,	PUNCT
dti-1318	1212	5	anderson	anderson	PROPN
dti-1318	1212	6	,	,	PUNCT
dti-1318	1212	7	j.l	j.l	PROPN
dti-1318	1212	8	.	.	PROPN
dti-1318	1212	9	,	,	PUNCT
dti-1318	1212	10	campbell	campbell	PROPN
dti-1318	1212	11	,	,	PUNCT
dti-1318	1212	12	e.m	e.m	PROPN
dti-1318	1212	13	.	.	PROPN
dti-1318	1212	14	,	,	PUNCT
dti-1318	1212	15	joseph	joseph	PROPN
dti-1318	1212	16	,	,	PUNCT
dti-1318	1212	17	a.m.	a.m.	PROPN
dti-1318	1212	18	and	and	CCONJ
dti-1318	1212	19	hope	hope	PROPN
dti-1318	1212	20	,	,	PUNCT
dti-1318	1212	21	t.j	t.j	PROPN
dti-1318	1212	22	.	.	PROPN
dti-1318	1212	23	2006	2006	NUM
dti-1318	1212	24	.	.	PUNCT
dti-1318	1213	1	proteasome	proteasome	NOUN
dti-1318	1213	2	inhibitors	inhibitor	NOUN
dti-1318	1213	3	uncouple	uncouple	ADJ
dti-1318	1213	4	rhesus	rhesus	VERB
dti-1318	1213	5	trim5alpha	trim5alpha	PRON
dti-1318	1213	6	restriction	restriction	NOUN
dti-1318	1213	7	of	of	ADP
dti-1318	1213	8	hiv-1	hiv-1	X
dti-1318	1213	9	reverse	reverse	ADJ
dti-1318	1213	10	transcription	transcription	NOUN
dti-1318	1213	11	and	and	CCONJ
dti-1318	1213	12	infection	infection	NOUN
dti-1318	1213	13	.	.	PUNCT
dti-1318	1214	1	proc	proc	PROPN
dti-1318	1214	2	.	.	PUNCT
dti-1318	1215	1	natl	natl	PROPN
dti-1318	1215	2	.	.	PUNCT
dti-1318	1216	1	acad	acad	PROPN
dti-1318	1216	2	.	.	PUNCT
dti-1318	1217	1	sci	sci	PROPN
dti-1318	1217	2	.	.	PUNCT
dti-1318	1217	3	u.s.a	u.s.a	PROPN
dti-1318	1217	4	.	.	PROPN
dti-1318	1217	5	,	,	PUNCT
dti-1318	1217	6	103:7465–7470	103:7465–7470	PROPN
dti-1318	1217	7	.	.	PUNCT
dti-1318	1218	1	wu	wu	PROPN
dti-1318	1218	2	,	,	PUNCT
dti-1318	1218	3	x.	x.	PROPN
dti-1318	1218	4	,	,	PUNCT
dti-1318	1218	5	liu	liu	PROPN
dti-1318	1218	6	,	,	PUNCT
dti-1318	1218	7	h.	h.	PROPN
dti-1318	1218	8	,	,	PUNCT
dti-1318	1218	9	xiao	xiao	PROPN
dti-1318	1218	10	,	,	PUNCT
dti-1318	1218	11	h.	h.	PROPN
dti-1318	1218	12	,	,	PUNCT
dti-1318	1218	13	conway	conway	PROPN
dti-1318	1218	14	,	,	PUNCT
dti-1318	1218	15	j.a	j.a	PROPN
dti-1318	1218	16	.	.	PROPN
dti-1318	1218	17	,	,	PUNCT
dti-1318	1218	18	hunter	hunter	NOUN
dti-1318	1218	19	,	,	PUNCT
dti-1318	1218	20	e.	e.	PROPN
dti-1318	1218	21	and	and	CCONJ
dti-1318	1218	22	kappes	kappes	PROPN
dti-1318	1218	23	,	,	PUNCT
dti-1318	1218	24	j.c	j.c	PROPN
dti-1318	1218	25	.	.	PROPN
dti-1318	1218	26	1997	1997	NUM
dti-1318	1218	27	.	.	PUNCT
dti-1318	1219	1	functional	functional	ADJ
dti-1318	1219	2	rt	rt	PROPN
dti-1318	1219	3	and	and	CCONJ
dti-1318	1219	4	in	in	SCONJ
dti-1318	1219	5	incorporated	incorporate	VERB
dti-1318	1219	6	into	into	ADP
dti-1318	1219	7	hiv-1	hiv-1	X
dti-1318	1219	8	particles	particle	NOUN
dti-1318	1219	9	independently	independently	ADV
dti-1318	1219	10	of	of	ADP
dti-1318	1219	11	the	the	DET
dti-1318	1219	12	gag	gag	NOUN
dti-1318	1219	13	/	/	SYM
dti-1318	1219	14	pol	pol	NOUN
dti-1318	1219	15	precursor	precursor	NOUN
dti-1318	1219	16	protein	protein	NOUN
dti-1318	1219	17	.	.	PUNCT
dti-1318	1220	1	embo	embo	PROPN
dti-1318	1220	2	j.	j.	PROPN
dti-1318	1220	3	,	,	PUNCT
dti-1318	1220	4	16:5113–5122	16:5113–5122	NUM
dti-1318	1220	5	.	.	PUNCT
dti-1318	1220	6	yeni	yeni	PROPN
dti-1318	1220	7	,	,	PUNCT
dti-1318	1220	8	p.	p.	NOUN
dti-1318	1220	9	2006	2006	NUM
dti-1318	1220	10	.	.	PUNCT
dti-1318	1221	1	update	update	NOUN
dti-1318	1221	2	on	on	ADP
dti-1318	1221	3	haart	haart	PROPN
dti-1318	1221	4	in	in	ADP
dti-1318	1221	5	hiv	hiv	PROPN
dti-1318	1221	6	.	.	PUNCT
dti-1318	1222	1	j.	j.	PROPN
dti-1318	1222	2	hepatol	hepatol	PROPN
dti-1318	1222	3	.	.	PUNCT
dti-1318	1222	4	,	,	PUNCT
dti-1318	1222	5	44	44	NUM
dti-1318	1222	6	:	:	PUNCT
dti-1318	1222	7	s100–103	s100–103	PROPN
dti-1318	1222	8	.	.	PROPN
dti-1318	1222	9	yeni	yeni	PROPN
dti-1318	1222	10	,	,	PUNCT
dti-1318	1222	11	p.g	p.g	PROPN
dti-1318	1222	12	.	.	PROPN
dti-1318	1222	13	,	,	PUNCT
dti-1318	1222	14	hammer	hammer	NOUN
dti-1318	1222	15	,	,	PUNCT
dti-1318	1222	16	s.m	s.m	PROPN
dti-1318	1222	17	.	.	PROPN
dti-1318	1222	18	,	,	PUNCT
dti-1318	1222	19	carpenter	carpenter	PROPN
dti-1318	1222	20	,	,	PUNCT
dti-1318	1222	21	c.c	c.c	PROPN
dti-1318	1222	22	.	.	PROPN
dti-1318	1222	23	,	,	PUNCT
dti-1318	1222	24	cooper	cooper	PROPN
dti-1318	1222	25	,	,	PUNCT
dti-1318	1222	26	d.a	d.a	PROPN
dti-1318	1222	27	.	.	PROPN
dti-1318	1222	28	,	,	PUNCT
dti-1318	1222	29	fischl	fischl	NOUN
dti-1318	1222	30	,	,	PUNCT
dti-1318	1222	31	m.a	m.a	PROPN
dti-1318	1222	32	.	.	PROPN
dti-1318	1222	33	,	,	PUNCT
dti-1318	1222	34	gatell	gatell	PROPN
dti-1318	1222	35	,	,	PUNCT
dti-1318	1222	36	j.m	j.m	PROPN
dti-1318	1222	37	.	.	PROPN
dti-1318	1222	38	,	,	PUNCT
dti-1318	1222	39	gazzard	gazzard	NOUN
dti-1318	1222	40	,	,	PUNCT
dti-1318	1222	41	b.g	b.g	PROPN
dti-1318	1222	42	.	.	PROPN
dti-1318	1222	43	,	,	PUNCT
dti-1318	1222	44	hirsch	hirsch	PROPN
dti-1318	1222	45	,	,	PUNCT
dti-1318	1222	46	m.s	m.s	PROPN
dti-1318	1222	47	.	.	PROPN
dti-1318	1222	48	,	,	PUNCT
dti-1318	1222	49	jacobsen	jacobsen	PROPN
dti-1318	1222	50	,	,	PUNCT
dti-1318	1222	51	d.m	d.m	PROPN
dti-1318	1222	52	.	.	PROPN
dti-1318	1222	53	,	,	PUNCT
dti-1318	1222	54	katzenstein	katzenstein	PROPN
dti-1318	1222	55	,	,	PUNCT
dti-1318	1222	56	d.a	d.a	PROPN
dti-1318	1222	57	.	.	PROPN
dti-1318	1222	58	,	,	PUNCT
dti-1318	1222	59	et	et	PROPN
dti-1318	1222	60	al	al	PROPN
dti-1318	1222	61	.	.	PROPN
dti-1318	1222	62	2002	2002	NUM
dti-1318	1222	63	.	.	PUNCT
dti-1318	1223	1	antiretroviral	antiretroviral	ADJ
dti-1318	1223	2	treatment	treatment	NOUN
dti-1318	1223	3	for	for	ADP
dti-1318	1223	4	adult	adult	NOUN
dti-1318	1223	5	hiv	hiv	PROPN
dti-1318	1223	6	infection	infection	NOUN
dti-1318	1223	7	in	in	ADP
dti-1318	1223	8	2002	2002	NUM
dti-1318	1223	9	:	:	PUNCT
dti-1318	1223	10	updated	update	VERB
dti-1318	1223	11	recommendations	recommendation	NOUN
dti-1318	1223	12	of	of	ADP
dti-1318	1223	13	the	the	DET
dti-1318	1223	14	international	international	ADJ
dti-1318	1223	15	aids	aids	PROPN
dti-1318	1223	16	society	society	PROPN
dti-1318	1223	17	-	-	PUNCT
dti-1318	1223	18	usa	usa	PROPN
dti-1318	1223	19	panel	panel	NOUN
dti-1318	1223	20	.	.	PUNCT
dti-1318	1224	1	jama	jama	PROPN
dti-1318	1224	2	,	,	PUNCT
dti-1318	1224	3	288:222–235	288:222–235	NUM
dti-1318	1224	4	.	.	PUNCT
dti-1318	1225	1	yu	yu	PROPN
dti-1318	1225	2	,	,	PUNCT
dti-1318	1225	3	q.	q.	PROPN
dti-1318	1225	4	,	,	PUNCT
dti-1318	1225	5	ottmann	ottmann	NOUN
dti-1318	1225	6	,	,	PUNCT
dti-1318	1225	7	m.	m.	NOUN
dti-1318	1225	8	,	,	PUNCT
dti-1318	1225	9	pechoux	pechoux	NOUN
dti-1318	1225	10	,	,	PUNCT
dti-1318	1225	11	c.	c.	PROPN
dti-1318	1225	12	,	,	PUNCT
dti-1318	1225	13	le	le	PROPN
dti-1318	1225	14	grice	grice	PROPN
dti-1318	1225	15	,	,	PUNCT
dti-1318	1225	16	s.	s.	PROPN
dti-1318	1225	17	and	and	CCONJ
dti-1318	1225	18	darlix	darlix	PROPN
dti-1318	1225	19	,	,	PUNCT
dti-1318	1225	20	j.l	j.l	PROPN
dti-1318	1225	21	.	.	PROPN
dti-1318	1225	22	1998	1998	NUM
dti-1318	1225	23	.	.	PUNCT
dti-1318	1226	1	mutations	mutation	NOUN
dti-1318	1226	2	in	in	ADP
dti-1318	1226	3	the	the	DET
dti-1318	1226	4	primer	primer	NOUN
dti-1318	1226	5	grip	grip	NOUN
dti-1318	1226	6	of	of	ADP
dti-1318	1226	7	human	human	ADJ
dti-1318	1226	8	immunodefi	immunodefi	PROPN
dti-1318	1226	9	ciency	ciency	NOUN
dti-1318	1226	10	virus	virus	NOUN
dti-1318	1226	11	type	type	NOUN
dti-1318	1226	12	1	1	NUM
dti-1318	1226	13	reverse	reverse	NOUN
dti-1318	1226	14	transcriptase	transcriptase	NOUN
dti-1318	1226	15	impair	impair	NOUN
dti-1318	1226	16	proviral	proviral	ADJ
dti-1318	1226	17	dna	dna	PROPN
dti-1318	1226	18	synthesis	synthesis	NOUN
dti-1318	1226	19	and	and	CCONJ
dti-1318	1226	20	virion	virion	NOUN
dti-1318	1226	21	maturation	maturation	NOUN
dti-1318	1226	22	.	.	PUNCT
dti-1318	1227	1	j.	j.	PROPN
dti-1318	1227	2	virol	virol	PROPN
dti-1318	1227	3	.	.	PUNCT
dti-1318	1227	4	,	,	PUNCT
dti-1318	1227	5	72:7676–7680	72:7676–7680	X
dti-1318	1227	6	.	.	PUNCT
dti-1318	1227	7	yu	yu	PROPN
dti-1318	1227	8	,	,	PUNCT
dti-1318	1227	9	x.	x.	PROPN
dti-1318	1227	10	,	,	PUNCT
dti-1318	1227	11	yu	yu	PROPN
dti-1318	1227	12	,	,	PUNCT
dti-1318	1227	13	y.	y.	PROPN
dti-1318	1227	14	,	,	PUNCT
dti-1318	1227	15	liu	liu	PROPN
dti-1318	1227	16	,	,	PUNCT
dti-1318	1227	17	b.	b.	PROPN
dti-1318	1227	18	,	,	PUNCT
dti-1318	1227	19	luo	luo	PROPN
dti-1318	1227	20	,	,	PUNCT
dti-1318	1227	21	k.	k.	PROPN
dti-1318	1227	22	,	,	PUNCT
dti-1318	1227	23	kong	kong	PROPN
dti-1318	1227	24	,	,	PUNCT
dti-1318	1227	25	w.	w.	PROPN
dti-1318	1227	26	,	,	PUNCT
dti-1318	1227	27	mao	mao	PROPN
dti-1318	1227	28	,	,	PUNCT
dti-1318	1227	29	p.	p.	PROPN
dti-1318	1227	30	and	and	CCONJ
dti-1318	1227	31	yu	yu	PROPN
dti-1318	1227	32	,	,	PUNCT
dti-1318	1227	33	x.f	x.f	PROPN
dti-1318	1227	34	.	.	PROPN
dti-1318	1227	35	2003	2003	NUM
dti-1318	1227	36	.	.	PUNCT
dti-1318	1228	1	induction	induction	NOUN
dti-1318	1228	2	of	of	ADP
dti-1318	1228	3	apobec3	apobec3	PROPN
dti-1318	1228	4	g	g	PROPN
dti-1318	1228	5	ubiquitination	ubiquitination	NOUN
dti-1318	1228	6	and	and	CCONJ
dti-1318	1228	7	degradation	degradation	NOUN
dti-1318	1228	8	by	by	ADP
dti-1318	1228	9	an	an	DET
dti-1318	1228	10	hiv-1	hiv-1	PUNCT
dti-1318	1228	11	vif	vif	PROPN
dti-1318	1228	12	-	-	PROPN
dti-1318	1228	13	cul5	cul5	PROPN
dti-1318	1228	14	-	-	PUNCT
dti-1318	1228	15	scf	scf	PROPN
dti-1318	1228	16	complex	complex	NOUN
dti-1318	1228	17	.	.	PUNCT
dti-1318	1229	1	science	science	NOUN
dti-1318	1229	2	,	,	PUNCT
dti-1318	1229	3	302:1056–1060	302:1056–1060	NOUN
dti-1318	1229	4	.	.	PUNCT
dti-1318	1230	1	yung	yung	PROPN
dti-1318	1230	2	,	,	PUNCT
dti-1318	1230	3	e.	e.	PROPN
dti-1318	1230	4	,	,	PUNCT
dti-1318	1230	5	sorin	sorin	NOUN
dti-1318	1230	6	,	,	PUNCT
dti-1318	1230	7	m.	m.	NOUN
dti-1318	1230	8	,	,	PUNCT
dti-1318	1230	9	pal	pal	NOUN
dti-1318	1230	10	,	,	PUNCT
dti-1318	1230	11	a.	a.	NOUN
dti-1318	1230	12	,	,	PUNCT
dti-1318	1230	13	craig	craig	PROPN
dti-1318	1230	14	,	,	PUNCT
dti-1318	1230	15	e.	e.	PROPN
dti-1318	1230	16	,	,	PUNCT
dti-1318	1230	17	morozov	morozov	PROPN
dti-1318	1230	18	,	,	PUNCT
dti-1318	1230	19	a.	a.	NOUN
dti-1318	1230	20	,	,	PUNCT
dti-1318	1230	21	delattre	delattre	NOUN
dti-1318	1230	22	,	,	PUNCT
dti-1318	1230	23	o.	o.	PROPN
dti-1318	1230	24	,	,	PUNCT
dti-1318	1230	25	kappes	kappes	PROPN
dti-1318	1230	26	,	,	PUNCT
dti-1318	1230	27	j.	j.	PROPN
dti-1318	1230	28	,	,	PUNCT
dti-1318	1230	29	ott	ott	PROPN
dti-1318	1230	30	,	,	PUNCT
dti-1318	1230	31	d.	d.	PROPN
dti-1318	1230	32	and	and	CCONJ
dti-1318	1230	33	kalpana	kalpana	PROPN
dti-1318	1230	34	,	,	PUNCT
dti-1318	1230	35	g.v	g.v	PROPN
dti-1318	1230	36	.	.	PROPN
dti-1318	1230	37	2001	2001	NUM
dti-1318	1230	38	.	.	PUNCT
dti-1318	1231	1	inhibition	inhibition	NOUN
dti-1318	1231	2	of	of	ADP
dti-1318	1231	3	hiv-1	hiv-1	X
dti-1318	1231	4	virion	virion	NOUN
dti-1318	1231	5	production	production	NOUN
dti-1318	1231	6	by	by	ADP
dti-1318	1231	7	a	a	DET
dti-1318	1231	8	transdominant	transdominant	ADJ
dti-1318	1231	9	mutant	mutant	NOUN
dti-1318	1231	10	of	of	ADP
dti-1318	1231	11	integrase	integrase	NOUN
dti-1318	1231	12	interactor	interactor	NOUN
dti-1318	1231	13	1	1	NUM
dti-1318	1231	14	.	.	PUNCT
dti-1318	1232	1	nat	nat	PROPN
dti-1318	1232	2	.	.	PUNCT
dti-1318	1233	1	med	med	PROPN
dti-1318	1233	2	.	.	PROPN
dti-1318	1233	3	,	,	PUNCT
dti-1318	1233	4	7:920–926	7:920–926	PROPN
dti-1318	1233	5	.	.	PUNCT
dti-1318	1234	1	yung	yung	PROPN
dti-1318	1234	2	,	,	PUNCT
dti-1318	1234	3	e.	e.	PROPN
dti-1318	1234	4	,	,	PUNCT
dti-1318	1234	5	sorin	sorin	NOUN
dti-1318	1234	6	,	,	PUNCT
dti-1318	1234	7	m.	m.	NOUN
dti-1318	1234	8	,	,	PUNCT
dti-1318	1234	9	wang	wang	PROPN
dti-1318	1234	10	,	,	PUNCT
dti-1318	1234	11	e.j	e.j	PROPN
dti-1318	1234	12	.	.	PROPN
dti-1318	1234	13	,	,	PUNCT
dti-1318	1234	14	perumal	perumal	PROPN
dti-1318	1234	15	,	,	PUNCT
dti-1318	1234	16	s.	s.	PROPN
dti-1318	1234	17	,	,	PUNCT
dti-1318	1234	18	ott	ott	PROPN
dti-1318	1234	19	,	,	PUNCT
dti-1318	1234	20	d.	d.	PROPN
dti-1318	1234	21	and	and	CCONJ
dti-1318	1234	22	kalpana	kalpana	PROPN
dti-1318	1234	23	,	,	PUNCT
dti-1318	1234	24	g.v	g.v	PROPN
dti-1318	1234	25	.	.	PROPN
dti-1318	1234	26	2004	2004	NUM
dti-1318	1234	27	.	.	PUNCT
dti-1318	1235	1	specifi	specifi	PROPN
dti-1318	1235	2	city	city	PROPN
dti-1318	1235	3	of	of	ADP
dti-1318	1235	4	interaction	interaction	NOUN
dti-1318	1235	5	of	of	ADP
dti-1318	1235	6	ini1	ini1	PROPN
dti-1318	1235	7	/	/	SYM
dti-1318	1235	8	hsnf5	hsnf5	NOUN
dti-1318	1235	9	with	with	ADP
dti-1318	1235	10	retroviral	retroviral	ADJ
dti-1318	1235	11	integrases	integrase	NOUN
dti-1318	1235	12	and	and	CCONJ
dti-1318	1235	13	its	its	PRON
dti-1318	1235	14	functional	functional	ADJ
dti-1318	1235	15	signifi	signifi	NOUN
dti-1318	1235	16	cance	cance	NOUN
dti-1318	1235	17	.	.	PUNCT
dti-1318	1236	1	j.	j.	PROPN
dti-1318	1236	2	virol	virol	PROPN
dti-1318	1236	3	.	.	PUNCT
dti-1318	1236	4	,	,	PUNCT
dti-1318	1237	1	78:2222–2231	78:2222–2231	X
dti-1318	1237	2	.	.	PUNCT
dti-1318	1238	1	zhang	zhang	PROPN
dti-1318	1238	2	,	,	PUNCT
dti-1318	1238	3	z.y	z.y	PROPN
dti-1318	1238	4	.	.	PROPN
dti-1318	1238	5	,	,	PUNCT
dti-1318	1238	6	poorman	poorman	PROPN
dti-1318	1238	7	,	,	PUNCT
dti-1318	1238	8	r.a	r.a	PROPN
dti-1318	1238	9	.	.	PROPN
dti-1318	1238	10	,	,	PUNCT
dti-1318	1238	11	maggiora	maggiora	PROPN
dti-1318	1238	12	,	,	PUNCT
dti-1318	1238	13	l.l	l.l	PROPN
dti-1318	1238	14	.	.	PROPN
dti-1318	1238	15	,	,	PUNCT
dti-1318	1238	16	heinrikson	heinrikson	PROPN
dti-1318	1238	17	,	,	PUNCT
dti-1318	1238	18	r.l	r.l	PROPN
dti-1318	1238	19	.	.	PROPN
dti-1318	1238	20	and	and	CCONJ
dti-1318	1238	21	kezdy	kezdy	PROPN
dti-1318	1238	22	,	,	PUNCT
dti-1318	1238	23	f.j	f.j	PROPN
dti-1318	1238	24	.	.	PROPN
dti-1318	1238	25	1991	1991	NUM
dti-1318	1238	26	.	.	PUNCT
dti-1318	1239	1	dissociative	dissociative	ADJ
dti-1318	1239	2	inhibition	inhibition	NOUN
dti-1318	1239	3	of	of	ADP
dti-1318	1239	4	dimeric	dimeric	ADJ
dti-1318	1239	5	enzymes	enzyme	NOUN
dti-1318	1239	6	.	.	PUNCT
dti-1318	1240	1	kinetic	kinetic	ADJ
dti-1318	1240	2	characterization	characterization	NOUN
dti-1318	1240	3	of	of	ADP
dti-1318	1240	4	the	the	DET
dti-1318	1240	5	inhibition	inhibition	NOUN
dti-1318	1240	6	of	of	ADP
dti-1318	1240	7	hiv-1	hiv-1	PUNCT
dti-1318	1240	8	protease	protease	NOUN
dti-1318	1240	9	by	by	ADP
dti-1318	1240	10	its	its	PRON
dti-1318	1240	11	cooh	cooh	NOUN
dti-1318	1240	12	-	-	PUNCT
dti-1318	1240	13	terminal	terminal	NOUN
dti-1318	1240	14	tetrapeptide	tetrapeptide	NOUN
dti-1318	1240	15	.	.	PUNCT
dti-1318	1241	1	j.	j.	PROPN
dti-1318	1241	2	biol	biol	PROPN
dti-1318	1241	3	.	.	PUNCT
dti-1318	1242	1	chem	chem	PROPN
dti-1318	1242	2	.	.	PUNCT
dti-1318	1242	3	,	,	PUNCT
dti-1318	1243	1	266:15591–15594	266:15591–15594	NUM
dti-1318	1243	2	.	.	PUNCT
dti-1318	1244	1	zhao	zhao	PROPN
dti-1318	1244	2	,	,	PUNCT
dti-1318	1244	3	l.	l.	PROPN
dti-1318	1244	4	,	,	PUNCT
dti-1318	1244	5	o’reilly	o’reilly	ADV
dti-1318	1244	6	,	,	PUNCT
dti-1318	1244	7	m.k	m.k	PROPN
dti-1318	1244	8	.	.	PROPN
dti-1318	1244	9	,	,	PUNCT
dti-1318	1244	10	shultz	shultz	PROPN
dti-1318	1244	11	,	,	PUNCT
dti-1318	1244	12	m.d	m.d	PROPN
dti-1318	1244	13	.	.	PROPN
dti-1318	1244	14	and	and	CCONJ
dti-1318	1244	15	chmielewski	chmielewski	PROPN
dti-1318	1244	16	,	,	PUNCT
dti-1318	1244	17	j.	j.	PROPN
dti-1318	1244	18	2003	2003	NUM
dti-1318	1244	19	.	.	PUNCT
dti-1318	1245	1	interfacial	interfacial	ADJ
dti-1318	1245	2	peptide	peptide	NOUN
dti-1318	1245	3	inhibitors	inhibitor	NOUN
dti-1318	1245	4	of	of	ADP
dti-1318	1245	5	hiv-1	hiv-1	X
dti-1318	1245	6	integrase	integrase	NOUN
dti-1318	1245	7	activity	activity	NOUN
dti-1318	1245	8	and	and	CCONJ
dti-1318	1245	9	dimerization	dimerization	NOUN
dti-1318	1245	10	.	.	PUNCT
dti-1318	1246	1	bioorg	bioorg	PROPN
dti-1318	1246	2	.	.	PUNCT
dti-1318	1247	1	med	med	PROPN
dti-1318	1247	2	.	.	PROPN
dti-1318	1247	3	chem	chem	PROPN
dti-1318	1247	4	.	.	PUNCT
dti-1318	1248	1	lett	lett	PROPN
dti-1318	1248	2	.	.	PROPN
dti-1318	1248	3	,	,	PUNCT
dti-1318	1248	4	13:1175	13:1175	PROPN
dti-1318	1248	5	-	-	SYM
dti-1318	1248	6	1177	1177	NUM
dti-1318	1248	7	.	.	PUNCT
dti-1318	1249	1	zhou	zhou	PROPN
dti-1318	1249	2	,	,	PUNCT
dti-1318	1249	3	j.	j.	PROPN
dti-1318	1249	4	,	,	PUNCT
dti-1318	1249	5	chen	chen	PROPN
dti-1318	1249	6	,	,	PUNCT
dti-1318	1249	7	c.h	c.h	PROPN
dti-1318	1249	8	.	.	PROPN
dti-1318	1249	9	and	and	CCONJ
dti-1318	1249	10	aiken	aiken	PROPN
dti-1318	1249	11	,	,	PUNCT
dti-1318	1249	12	c.	c.	PROPN
dti-1318	1249	13	2004	2004	NUM
dti-1318	1249	14	.	.	PUNCT
dti-1318	1250	1	the	the	DET
dti-1318	1250	2	sequence	sequence	NOUN
dti-1318	1250	3	of	of	ADP
dti-1318	1250	4	the	the	DET
dti-1318	1250	5	ca	ca	NOUN
dti-1318	1250	6	-	-	PUNCT
dti-1318	1250	7	sp1	sp1	NOUN
dti-1318	1250	8	junction	junction	NOUN
dti-1318	1250	9	accounts	account	VERB
dti-1318	1250	10	for	for	ADP
dti-1318	1250	11	the	the	DET
dti-1318	1250	12	differential	differential	ADJ
dti-1318	1250	13	sensitivity	sensitivity	NOUN
dti-1318	1250	14	of	of	ADP
dti-1318	1250	15	hiv-1	hiv-1	PUNCT
dti-1318	1250	16	and	and	CCONJ
dti-1318	1250	17	siv	siv	PROPN
dti-1318	1250	18	to	to	ADP
dti-1318	1250	19	the	the	DET
dti-1318	1250	20	small	small	ADJ
dti-1318	1250	21	molecule	molecule	NOUN
dti-1318	1250	22	maturation	maturation	NOUN
dti-1318	1250	23	inhibitor	inhibitor	NOUN
dti-1318	1250	24	3	3	NUM
dti-1318	1250	25	-	-	PUNCT
dti-1318	1250	26	o-{3′,3′-dimethylsuccinyl}-betulinic	o-{3′,3′-dimethylsuccinyl}-betulinic	ADJ
dti-1318	1250	27	acid	acid	NOUN
dti-1318	1250	28	.	.	PUNCT
dti-1318	1251	1	retrovirology	retrovirology	NOUN
dti-1318	1251	2	,	,	PUNCT
dti-1318	1251	3	1:15	1:15	NUM
dti-1318	1251	4	.	.	PUNCT
dti-1318	1251	5	182	182	NUM
dti-1318	1251	6	wapling	waple	VERB
dti-1318	1251	7	et	et	PROPN
dti-1318	1251	8	al	al	PROPN
dti-1318	1251	9	drug	drug	PROPN
dti-1318	1251	10	target	target	NOUN
dti-1318	1251	11	insights	insight	NOUN
dti-1318	1251	12	2007	2007	NUM
dti-1318	1251	13	:	:	PUNCT
dti-1318	1251	14	2	2	NUM
dti-1318	1251	15	zhou	zhou	PROPN
dti-1318	1251	16	,	,	PUNCT
dti-1318	1251	17	j.	j.	PROPN
dti-1318	1251	18	,	,	PUNCT
dti-1318	1251	19	chen	chen	PROPN
dti-1318	1251	20	,	,	PUNCT
dti-1318	1251	21	c.h	c.h	PROPN
dti-1318	1251	22	.	.	PROPN
dti-1318	1251	23	and	and	CCONJ
dti-1318	1251	24	aiken	aiken	PROPN
dti-1318	1251	25	,	,	PUNCT
dti-1318	1251	26	c.	c.	PROPN
dti-1318	1251	27	2006	2006	NUM
dti-1318	1251	28	.	.	PUNCT
dti-1318	1252	1	hiv-1	hiv-1	X
dti-1318	1252	2	resistance	resistance	NOUN
dti-1318	1252	3	to	to	ADP
dti-1318	1252	4	the	the	DET
dti-1318	1252	5	small	small	ADJ
dti-1318	1252	6	molecule	molecule	NOUN
dti-1318	1252	7	maturation	maturation	NOUN
dti-1318	1252	8	inhibitor	inhibitor	NOUN
dti-1318	1252	9	3	3	NUM
dti-1318	1252	10	-	-	PUNCT
dti-1318	1252	11	o-{3′,3′-dimethylsuccinyl}-betulinic	o-{3′,3′-dimethylsuccinyl}-betulinic	ADJ
dti-1318	1252	12	acid	acid	NOUN
dti-1318	1252	13	is	be	AUX
dti-1318	1252	14	conferred	confer	VERB
dti-1318	1252	15	by	by	ADP
dti-1318	1252	16	a	a	DET
dti-1318	1252	17	variety	variety	NOUN
dti-1318	1252	18	of	of	ADP
dti-1318	1252	19	single	single	ADJ
dti-1318	1252	20	amino	amino	NOUN
dti-1318	1252	21	acid	acid	NOUN
dti-1318	1252	22	substitutions	substitution	NOUN
dti-1318	1252	23	at	at	ADP
dti-1318	1252	24	the	the	DET
dti-1318	1252	25	ca	ca	NOUN
dti-1318	1252	26	-	-	PUNCT
dti-1318	1252	27	sp1	sp1	NOUN
dti-1318	1252	28	cleavage	cleavage	NOUN
dti-1318	1252	29	site	site	NOUN
dti-1318	1252	30	in	in	ADP
dti-1318	1252	31	gag	gag	NOUN
dti-1318	1252	32	.	.	PUNCT
dti-1318	1253	1	j.	j.	PROPN
dti-1318	1253	2	virol	virol	PROPN
dti-1318	1253	3	.	.	PUNCT
dti-1318	1253	4	,	,	PUNCT
dti-1318	1253	5	80:12095–12101	80:12095–12101	NUM
dti-1318	1253	6	.	.	PUNCT
dti-1318	1254	1	zhou	zhou	PROPN
dti-1318	1254	2	,	,	PUNCT
dti-1318	1254	3	j.	j.	PROPN
dti-1318	1254	4	,	,	PUNCT
dti-1318	1254	5	huang	huang	PROPN
dti-1318	1254	6	,	,	PUNCT
dti-1318	1254	7	l.	l.	PROPN
dti-1318	1254	8	,	,	PUNCT
dti-1318	1254	9	hachey	hachey	PROPN
dti-1318	1254	10	,	,	PUNCT
dti-1318	1254	11	d.l	d.l	PROPN
dti-1318	1254	12	.	.	PROPN
dti-1318	1254	13	,	,	PUNCT
dti-1318	1254	14	chen	chen	PROPN
dti-1318	1254	15	,	,	PUNCT
dti-1318	1254	16	c.h	c.h	PROPN
dti-1318	1254	17	.	.	PROPN
dti-1318	1254	18	and	and	CCONJ
dti-1318	1254	19	aiken	aiken	PROPN
dti-1318	1254	20	,	,	PUNCT
dti-1318	1254	21	c.	c.	PROPN
dti-1318	1254	22	2005	2005	NUM
dti-1318	1254	23	.	.	PUNCT
dti-1318	1255	1	inhibition	inhibition	NOUN
dti-1318	1255	2	of	of	ADP
dti-1318	1255	3	hiv-1	hiv-1	X
dti-1318	1255	4	maturation	maturation	NOUN
dti-1318	1255	5	via	via	ADP
dti-1318	1255	6	drug	drug	NOUN
dti-1318	1255	7	association	association	NOUN
dti-1318	1255	8	with	with	ADP
dti-1318	1255	9	the	the	DET
dti-1318	1255	10	viral	viral	ADJ
dti-1318	1255	11	gag	gag	NOUN
dti-1318	1255	12	protein	protein	NOUN
dti-1318	1255	13	in	in	ADP
dti-1318	1255	14	immature	immature	ADJ
dti-1318	1255	15	hiv-1	hiv-1	X
dti-1318	1255	16	particles	particle	NOUN
dti-1318	1255	17	.	.	PUNCT
dti-1318	1256	1	j.	j.	PROPN
dti-1318	1256	2	biol	biol	PROPN
dti-1318	1256	3	.	.	PUNCT
dti-1318	1257	1	chem	chem	PROPN
dti-1318	1257	2	.	.	PUNCT
dti-1318	1257	3	,	,	PUNCT
dti-1318	1257	4	280:42149	280:42149	NUM
dti-1318	1257	5	–	–	PUNCT
dti-1318	1257	6	42155	42155	NUM
dti-1318	1257	7	.	.	PUNCT
dti-1318	1258	1	zutshi	zutshi	PROPN
dti-1318	1258	2	,	,	PUNCT
dti-1318	1258	3	r.	r.	PROPN
dti-1318	1258	4	and	and	CCONJ
dti-1318	1258	5	chmielewski	chmielewski	PROPN
dti-1318	1258	6	,	,	PUNCT
dti-1318	1258	7	j.	j.	PROPN
dti-1318	1258	8	2000	2000	NUM
dti-1318	1258	9	.	.	PUNCT
dti-1318	1259	1	targeting	target	VERB
dti-1318	1259	2	the	the	DET
dti-1318	1259	3	dimerization	dimerization	NOUN
dti-1318	1259	4	interface	interface	NOUN
dti-1318	1259	5	for	for	ADP
dti-1318	1259	6	irreversible	irreversible	ADJ
dti-1318	1259	7	inhibition	inhibition	NOUN
dti-1318	1259	8	of	of	ADP
dti-1318	1259	9	hiv-1	hiv-1	ADJ
dti-1318	1259	10	protease	protease	NOUN
dti-1318	1259	11	.	.	PUNCT
dti-1318	1260	1	bioorg	bioorg	PROPN
dti-1318	1260	2	.	.	PUNCT
dti-1318	1261	1	med	med	PROPN
dti-1318	1261	2	.	.	PROPN
dti-1318	1261	3	chem	chem	PROPN
dti-1318	1261	4	.	.	PUNCT
dti-1318	1262	1	lett	lett	PROPN
dti-1318	1262	2	.	.	PROPN
dti-1318	1262	3	,	,	PUNCT
dti-1318	1263	1	10:1901–1903	10:1901–1903	NUM
dti-1318	1263	2	.	.	PUNCT
dti-1318	1264	1	<	<	X
dti-1318	1264	2	<	<	X
dti-1318	1264	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1318	1264	4	false	false	ADJ
dti-1318	1264	5	/allowtransparency	/allowtransparency	NOUN
dti-1318	1264	6	false	false	ADJ
dti-1318	1264	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1318	1264	8	true	true	ADJ
dti-1318	1264	9	/autorotatepages	/autorotatepage	NOUN
dti-1318	1264	10	/none	/none	PUNCT
dti-1318	1264	11	/binding	/binding	PUNCT
dti-1318	1264	12	/left	/left	ADJ
dti-1318	1265	1	/calgrayprofile	/calgrayprofile	VERB
dti-1318	1265	2	(	(	PUNCT
dti-1318	1265	3	dot	dot	NOUN
dti-1318	1265	4	gain	gain	NOUN
dti-1318	1265	5	20	20	NUM
dti-1318	1265	6	%	%	NOUN
dti-1318	1265	7	)	)	PUNCT
dti-1318	1265	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1318	1266	1	(	(	PUNCT
dti-1318	1266	2	srgb	srgb	PROPN
dti-1318	1266	3	iec61966	iec61966	NOUN
dti-1318	1266	4	-	-	PUNCT
dti-1318	1266	5	2.1	2.1	NUM
dti-1318	1266	6	)	)	PUNCT
dti-1318	1266	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1318	1267	1	(	(	PUNCT
dti-1318	1267	2	u.s	u.s	PROPN
dti-1318	1267	3	.	.	PROPN
dti-1318	1267	4	web	web	NOUN
dti-1318	1267	5	coated	coat	VERB
dti-1318	1267	6	\050swop\051	\050swop\051	ADJ
dti-1318	1267	7	v2	v2	NOUN
dti-1318	1267	8	)	)	PUNCT
dti-1318	1267	9	/srgbprofile	/srgbprofile	PUNCT
dti-1318	1267	10	(	(	PUNCT
dti-1318	1267	11	srgb	srgb	PROPN
dti-1318	1267	12	iec61966	iec61966	NOUN
dti-1318	1267	13	-	-	PUNCT
dti-1318	1267	14	2.1	2.1	NUM
dti-1318	1267	15	)	)	PUNCT
dti-1318	1267	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1318	1268	1	/error	/error	INTJ
dti-1318	1268	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1318	1269	1	1.4	1.4	NUM
dti-1318	1269	2	/compressobjects	/compressobject	NOUN
dti-1318	1269	3	/tags	/tag	VERB
dti-1318	1269	4	/compresspages	/compresspage	NOUN
dti-1318	1269	5	true	true	ADJ
dti-1318	1269	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1318	1269	7	true	true	ADJ
dti-1318	1269	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1318	1269	9	true	true	ADJ
dti-1318	1269	10	/createjdffile	/createjdffile	ADJ
dti-1318	1269	11	false	false	ADJ
dti-1318	1269	12	/createjobticket	/createjobticket	NOUN
dti-1318	1269	13	false	false	ADJ
dti-1318	1269	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1318	1269	15	/default	/default	PUNCT
dti-1318	1269	16	/detectblends	/detectblend	NOUN
dti-1318	1269	17	true	true	ADJ
dti-1318	1269	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1318	1269	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1318	1269	20	/dothumbnails	/dothumbnail	VERB
dti-1318	1269	21	false	false	ADJ
dti-1318	1269	22	/embedallfonts	/embedallfont	NOUN
dti-1318	1269	23	true	true	ADJ
dti-1318	1269	24	/embedjoboptions	/embedjoboption	NOUN
dti-1318	1269	25	true	true	ADJ
dti-1318	1269	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1318	1269	27	0	0	NUM
dti-1318	1269	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1318	1269	29	false	false	ADJ
dti-1318	1269	30	/endpage	/endpage	NOUN
dti-1318	1269	31	-1	-1	NOUN
dti-1318	1269	32	/imagememory	/imagememory	NUM
dti-1318	1270	1	1048576	1048576	NUM
dti-1318	1270	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1318	1270	3	false	false	ADJ
dti-1318	1270	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1318	1270	5	100	100	NUM
dti-1318	1270	6	/optimize	/optimize	NOUN
dti-1318	1270	7	true	true	ADJ
dti-1318	1270	8	/opm	/opm	NOUN
dti-1318	1270	9	1	1	NUM
dti-1318	1270	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1318	1270	11	true	true	ADJ
dti-1318	1270	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1318	1270	13	true	true	ADJ
dti-1318	1270	14	/preservecopypage	/preservecopypage	NOUN
dti-1318	1270	15	true	true	ADJ
dti-1318	1270	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1318	1270	17	true	true	ADJ
dti-1318	1270	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1318	1270	19	false	false	ADJ
dti-1318	1270	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1318	1270	21	false	false	ADJ
dti-1318	1270	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1318	1270	23	true	true	ADJ
dti-1318	1270	24	/startpage	/startpage	NOUN
dti-1318	1270	25	1	1	NUM
dti-1318	1270	26	/subsetfonts	/subsetfont	NOUN
dti-1318	1270	27	true	true	ADJ
dti-1318	1270	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1318	1270	29	/apply	/apply	PUNCT
dti-1318	1270	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1318	1271	1	/preserve	/preserve	NOUN
dti-1318	1271	2	/useprologue	/useprologue	NOUN
dti-1318	1271	3	false	false	ADJ
dti-1318	1271	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1318	1271	5	(	(	PUNCT
dti-1318	1271	6	)	)	PUNCT
dti-1318	1271	7	/alwaysembed	/alwaysembe	VERB
dti-1318	1271	8	[	[	PUNCT
dti-1318	1271	9	true	true	ADJ
dti-1318	1271	10	]	]	PUNCT
dti-1318	1271	11	/neverembed	/neverembed	PUNCT
dti-1318	1272	1	[	[	PUNCT
dti-1318	1272	2	true	true	ADJ
dti-1318	1272	3	]	]	PUNCT
dti-1318	1272	4	/antialiascolorimages	/antialiascolorimages	X
dti-1318	1272	5	false	false	ADJ
dti-1318	1272	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1318	1272	7	true	true	ADJ
dti-1318	1272	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1318	1272	9	/bicubic	/bicubic	NOUN
dti-1318	1272	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1318	1272	11	300	300	NUM
dti-1318	1272	12	/colorimagedepth	/colorimagedepth	PRON
dti-1318	1273	1	-1	-1	INTJ
dti-1318	1273	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1318	1273	3	1.50000	1.50000	NUM
dti-1318	1273	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1318	1273	5	true	true	ADJ
dti-1318	1273	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1318	1273	7	/dctencode	/dctencode	PUNCT
dti-1318	1273	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1318	1273	9	true	true	ADJ
dti-1318	1273	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1318	1273	11	/jpeg	/jpeg	PUNCT
dti-1318	1273	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1318	1274	1	<	<	X
dti-1318	1274	2	<	<	X
dti-1318	1274	3	/qfactor	/qfactor	NOUN
dti-1318	1274	4	0.15	0.15	NUM
dti-1318	1274	5	/hsamples	/hsample	NOUN
dti-1318	1275	1	[	[	X
dti-1318	1275	2	1	1	NUM
dti-1318	1275	3	1	1	NUM
dti-1318	1275	4	1	1	NUM
dti-1318	1275	5	1	1	NUM
dti-1318	1275	6	]	]	PUNCT
dti-1318	1275	7	/vsamples	/vsample	NOUN
dti-1318	1276	1	[	[	X
dti-1318	1276	2	1	1	NUM
dti-1318	1276	3	1	1	NUM
dti-1318	1276	4	1	1	NUM
dti-1318	1276	5	1	1	NUM
dti-1318	1276	6	]	]	PUNCT
dti-1318	1276	7	>	>	PUNCT
dti-1318	1276	8	>	>	X
dti-1318	1276	9	/colorimagedict	/colorimagedict	PUNCT
dti-1318	1277	1	<	<	X
dti-1318	1277	2	<	<	X
dti-1318	1277	3	/qfactor	/qfactor	NOUN
dti-1318	1277	4	0.15	0.15	NUM
dti-1318	1277	5	/hsamples	/hsample	NOUN
dti-1318	1278	1	[	[	X
dti-1318	1278	2	1	1	NUM
dti-1318	1278	3	1	1	NUM
dti-1318	1278	4	1	1	NUM
dti-1318	1278	5	1	1	NUM
dti-1318	1278	6	]	]	PUNCT
dti-1318	1278	7	/vsamples	/vsample	NOUN
dti-1318	1279	1	[	[	X
dti-1318	1279	2	1	1	NUM
dti-1318	1279	3	1	1	NUM
dti-1318	1279	4	1	1	NUM
dti-1318	1279	5	1	1	NUM
dti-1318	1279	6	]	]	PUNCT
dti-1318	1279	7	>	>	PUNCT
dti-1318	1279	8	>	>	X
dti-1318	1279	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1318	1280	1	<	<	X
dti-1318	1280	2	<	<	X
dti-1318	1280	3	/tilewidth	/tilewidth	PUNCT
dti-1318	1280	4	256	256	NUM
dti-1318	1280	5	/tileheight	/tileheight	NUM
dti-1318	1280	6	256	256	NUM
dti-1318	1280	7	/quality	/quality	NOUN
dti-1318	1280	8	30	30	NUM
dti-1318	1280	9	>	>	PUNCT
dti-1318	1280	10	>	>	X
dti-1318	1280	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1318	1280	12	<	<	X
dti-1318	1280	13	<	<	X
dti-1318	1280	14	/tilewidth	/tilewidth	PUNCT
dti-1318	1280	15	256	256	NUM
dti-1318	1280	16	/tileheight	/tileheight	NUM
dti-1318	1280	17	256	256	NUM
dti-1318	1280	18	/quality	/quality	NOUN
dti-1318	1280	19	30	30	NUM
dti-1318	1280	20	>	>	PUNCT
dti-1318	1280	21	>	>	X
dti-1318	1280	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1318	1280	23	false	false	ADJ
dti-1318	1280	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1318	1281	1	true	true	ADJ
dti-1318	1281	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1318	1281	3	/bicubic	/bicubic	NOUN
dti-1318	1281	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1318	1281	5	300	300	NUM
dti-1318	1281	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1318	1281	7	-1	-1	PUNCT
dti-1318	1281	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1318	1282	1	1.50000	1.50000	NUM
dti-1318	1282	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1318	1282	3	true	true	ADJ
dti-1318	1282	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1318	1282	5	/dctencode	/dctencode	PUNCT
dti-1318	1283	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1318	1283	2	true	true	ADJ
dti-1318	1283	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1318	1283	4	/jpeg	/jpeg	PUNCT
dti-1318	1283	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1318	1284	1	<	<	X
dti-1318	1284	2	<	<	X
dti-1318	1284	3	/qfactor	/qfactor	NOUN
dti-1318	1284	4	0.15	0.15	NUM
dti-1318	1284	5	/hsamples	/hsample	NOUN
dti-1318	1285	1	[	[	X
dti-1318	1285	2	1	1	NUM
dti-1318	1285	3	1	1	NUM
dti-1318	1285	4	1	1	NUM
dti-1318	1285	5	1	1	NUM
dti-1318	1285	6	]	]	PUNCT
dti-1318	1285	7	/vsamples	/vsample	NOUN
dti-1318	1286	1	[	[	X
dti-1318	1286	2	1	1	NUM
dti-1318	1286	3	1	1	NUM
dti-1318	1286	4	1	1	NUM
dti-1318	1286	5	1	1	NUM
dti-1318	1286	6	]	]	PUNCT
dti-1318	1286	7	>	>	PUNCT
dti-1318	1286	8	>	>	X
dti-1318	1286	9	/grayimagedict	/grayimagedict	PUNCT
dti-1318	1287	1	<	<	X
dti-1318	1287	2	<	<	X
dti-1318	1287	3	/qfactor	/qfactor	NOUN
dti-1318	1287	4	0.15	0.15	NUM
dti-1318	1287	5	/hsamples	/hsample	NOUN
dti-1318	1288	1	[	[	X
dti-1318	1288	2	1	1	NUM
dti-1318	1288	3	1	1	NUM
dti-1318	1288	4	1	1	NUM
dti-1318	1288	5	1	1	NUM
dti-1318	1288	6	]	]	PUNCT
dti-1318	1288	7	/vsamples	/vsample	NOUN
dti-1318	1289	1	[	[	X
dti-1318	1289	2	1	1	NUM
dti-1318	1289	3	1	1	NUM
dti-1318	1289	4	1	1	NUM
dti-1318	1289	5	1	1	NUM
dti-1318	1289	6	]	]	PUNCT
dti-1318	1289	7	>	>	X
dti-1318	1289	8	>	>	X
dti-1318	1289	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1318	1290	1	<	<	X
dti-1318	1290	2	<	<	X
dti-1318	1290	3	/tilewidth	/tilewidth	PUNCT
dti-1318	1290	4	256	256	NUM
dti-1318	1290	5	/tileheight	/tileheight	NUM
dti-1318	1290	6	256	256	NUM
dti-1318	1290	7	/quality	/quality	NOUN
dti-1318	1290	8	30	30	NUM
dti-1318	1290	9	>	>	PUNCT
dti-1318	1290	10	>	>	X
dti-1318	1290	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1318	1290	12	<	<	X
dti-1318	1290	13	<	<	X
dti-1318	1290	14	/tilewidth	/tilewidth	PUNCT
dti-1318	1290	15	256	256	NUM
dti-1318	1290	16	/tileheight	/tileheight	NUM
dti-1318	1290	17	256	256	NUM
dti-1318	1290	18	/quality	/quality	NOUN
dti-1318	1290	19	30	30	NUM
dti-1318	1290	20	>	>	PUNCT
dti-1318	1290	21	>	>	X
dti-1318	1290	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1318	1290	23	false	false	ADJ
dti-1318	1290	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1318	1290	25	true	true	ADJ
dti-1318	1290	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1318	1290	27	/bicubic	/bicubic	NOUN
dti-1318	1290	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1318	1290	29	1200	1200	NUM
dti-1318	1290	30	/monoimagedepth	/monoimagedepth	PRON
dti-1318	1290	31	-1	-1	PUNCT
dti-1318	1290	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1318	1290	33	1.50000	1.50000	NUM
dti-1318	1290	34	/encodemonoimages	/encodemonoimage	NOUN
dti-1318	1290	35	true	true	ADJ
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dti-1318	1304	8	/sve	/sve	NOUN
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dti-1318	1305	4	/enu	/enu	PROPN
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dti-1318	1305	12	setdistillerparams	setdistillerparam	NOUN
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dti-1318	1306	3	/hwresolution	/hwresolution	NOUN
dti-1318	1307	1	[	[	X
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dti-1318	1308	7	setpagedevice	setpagedevice	PROPN