id	sid	tid	token	lemma	pos
dti-1319	1	1	ulrich	ulrich	PROPN
dti-1319	1	2	et	et	PROPN
dti-1319	1	3	al.indd	al.indd	NOUN
dti-1319	1	4	drug	drug	NOUN
dti-1319	1	5	target	target	NOUN
dti-1319	1	6	insights	insight	VERB
dti-1319	1	7	2007:2	2007:2	NUM
dti-1319	1	8	183–196	183–196	NUM
dti-1319	1	9	183	183	NUM
dti-1319	1	10	review	review	NOUN
dti-1319	1	11	correspondence	correspondence	NOUN
dti-1319	1	12	:	:	PUNCT
dti-1319	1	13	henning	henning	PROPN
dti-1319	1	14	ulrich	ulrich	PROPN
dti-1319	1	15	,	,	PUNCT
dti-1319	1	16	departamento	departamento	PROPN
dti-1319	1	17	de	de	PROPN
dti-1319	1	18	bioquímica	bioquímica	PROPN
dti-1319	1	19	,	,	PUNCT
dti-1319	1	20	instituto	instituto	PROPN
dti-1319	1	21	de	de	PROPN
dti-1319	1	22	química	química	PROPN
dti-1319	1	23	,	,	PUNCT
dti-1319	1	24	universidade	universidade	PROPN
dti-1319	1	25	de	de	PROPN
dti-1319	1	26	são	são	PROPN
dti-1319	1	27	paulo	paulo	PROPN
dti-1319	1	28	,	,	PUNCT
dti-1319	1	29	av	av	PROPN
dti-1319	1	30	.	.	PROPN
dti-1319	1	31	prof	prof	PROPN
dti-1319	1	32	.	.	PUNCT
dti-1319	2	1	lineu	lineu	PROPN
dti-1319	2	2	prestes	preste	VERB
dti-1319	2	3	748	748	NUM
dti-1319	2	4	,	,	PUNCT
dti-1319	2	5	05508	05508	NUM
dti-1319	2	6	-	-	SYM
dti-1319	2	7	900	900	NUM
dti-1319	2	8	,	,	PUNCT
dti-1319	2	9	são	são	NOUN
dti-1319	2	10	paulo	paulo	PROPN
dti-1319	2	11	,	,	PUNCT
dti-1319	2	12	sp	sp	NOUN
dti-1319	2	13	,	,	PUNCT
dti-1319	2	14	brazil	brazil	PROPN
dti-1319	2	15	.	.	PUNCT
dti-1319	3	1	tel	tel	ADP
dti-1319	3	2	:	:	PUNCT
dti-1319	3	3	+	+	NUM
dti-1319	3	4	55	55	NUM
dti-1319	3	5	-	-	SYM
dti-1319	3	6	11	11	NUM
dti-1319	3	7	-	-	PUNCT
dti-1319	3	8	3091	3091	NUM
dti-1319	3	9	-	-	SYM
dti-1319	3	10	3810	3810	NUM
dti-1319	3	11	,	,	PUNCT
dti-1319	3	12	ext	ext	NOUN
dti-1319	3	13	.	.	PROPN
dti-1319	3	14	223	223	NUM
dti-1319	3	15	;	;	PUNCT
dti-1319	3	16	email	email	NOUN
dti-1319	3	17	:	:	PUNCT
dti-1319	3	18	henning@iq.usp.br	henning@iq.usp.br	VERB
dti-1319	3	19	please	please	INTJ
dti-1319	3	20	note	note	VERB
dti-1319	3	21	that	that	SCONJ
dti-1319	3	22	this	this	DET
dti-1319	3	23	article	article	NOUN
dti-1319	3	24	may	may	AUX
dti-1319	3	25	not	not	PART
dti-1319	3	26	be	be	AUX
dti-1319	3	27	used	use	VERB
dti-1319	3	28	for	for	ADP
dti-1319	3	29	commercial	commercial	ADJ
dti-1319	3	30	purposes	purpose	NOUN
dti-1319	3	31	.	.	PUNCT
dti-1319	4	1	for	for	ADP
dti-1319	4	2	further	further	ADJ
dti-1319	4	3	information	information	NOUN
dti-1319	4	4	please	please	INTJ
dti-1319	4	5	refer	refer	VERB
dti-1319	4	6	to	to	ADP
dti-1319	4	7	the	the	DET
dti-1319	4	8	copyright	copyright	NOUN
dti-1319	4	9	statement	statement	NOUN
dti-1319	4	10	at	at	ADP
dti-1319	4	11	http://www.la-press.com/copyright.htm	http://www.la-press.com/copyright.htm	PROPN
dti-1319	4	12	delivery	delivery	NOUN
dti-1319	4	13	systems	system	NOUN
dti-1319	4	14	for	for	ADP
dti-1319	4	15	in	in	ADP
dti-1319	4	16	vivo	vivo	ADJ
dti-1319	4	17	use	use	NOUN
dti-1319	4	18	of	of	ADP
dti-1319	4	19	nucleic	nucleic	ADJ
dti-1319	4	20	acid	acid	NOUN
dti-1319	4	21	drugs	drug	NOUN
dti-1319	4	22	resende	resende	NOUN
dti-1319	4	23	r.r1,4	r.r1,4	ADV
dti-1319	4	24	,	,	PUNCT
dti-1319	4	25	torres	torre	VERB
dti-1319	4	26	h.a.m2	h.a.m2	PROPN
dti-1319	4	27	,	,	PUNCT
dti-1319	4	28	yuahasi	yuahasi	PROPN
dti-1319	4	29	k.k3	k.k3	PROPN
dti-1319	4	30	,	,	PUNCT
dti-1319	4	31	majumder	majumder	NOUN
dti-1319	4	32	p1	p1	PROPN
dti-1319	4	33	and	and	CCONJ
dti-1319	4	34	ulrich	ulrich	PROPN
dti-1319	4	35	h1	h1	PROPN
dti-1319	4	36	1departamento	1departamento	NUM
dti-1319	4	37	de	de	X
dti-1319	4	38	bioquímica	bioquímica	PROPN
dti-1319	4	39	,	,	PUNCT
dti-1319	4	40	instituto	instituto	PROPN
dti-1319	4	41	de	de	PROPN
dti-1319	4	42	química	química	PROPN
dti-1319	4	43	,	,	PUNCT
dti-1319	4	44	universidade	universidade	PROPN
dti-1319	4	45	de	de	PROPN
dti-1319	4	46	são	são	PROPN
dti-1319	4	47	paulo	paulo	PROPN
dti-1319	4	48	,	,	PUNCT
dti-1319	4	49	são	são	PROPN
dti-1319	4	50	paulo	paulo	PROPN
dti-1319	4	51	05508	05508	NUM
dti-1319	4	52	-	-	SYM
dti-1319	4	53	900	900	NUM
dti-1319	4	54	,	,	PUNCT
dti-1319	4	55	sp	sp	NOUN
dti-1319	4	56	,	,	PUNCT
dti-1319	4	57	brazil	brazil	PROPN
dti-1319	4	58	.	.	PUNCT
dti-1319	5	1	2departamento	2departamento	NUM
dti-1319	5	2	de	de	X
dti-1319	5	3	biofísica	biofísica	PROPN
dti-1319	5	4	,	,	PUNCT
dti-1319	5	5	universidade	universidade	PROPN
dti-1319	5	6	federal	federal	PROPN
dti-1319	5	7	de	de	PROPN
dti-1319	5	8	são	são	PROPN
dti-1319	5	9	paulo	paulo	PROPN
dti-1319	5	10	,	,	PUNCT
dti-1319	5	11	são	são	PROPN
dti-1319	5	12	paulo	paulo	PROPN
dti-1319	5	13	04023	04023	NUM
dti-1319	5	14	-	-	SYM
dti-1319	5	15	062	062	NUM
dti-1319	5	16	,	,	PUNCT
dti-1319	5	17	sp	sp	NOUN
dti-1319	5	18	,	,	PUNCT
dti-1319	5	19	brazil	brazil	PROPN
dti-1319	5	20	.	.	PUNCT
dti-1319	6	1	3departamento	3departamento	NUM
dti-1319	6	2	de	de	PROPN
dti-1319	6	3	neurologia	neurologia	PROPN
dti-1319	6	4	e	e	PROPN
dti-1319	6	5	neurocirurgia	neurocirurgia	PROPN
dti-1319	6	6	,	,	PUNCT
dti-1319	6	7	universidade	universidade	PROPN
dti-1319	6	8	federal	federal	PROPN
dti-1319	6	9	de	de	PROPN
dti-1319	6	10	são	são	PROPN
dti-1319	6	11	paulo	paulo	PROPN
dti-1319	6	12	,	,	PUNCT
dti-1319	6	13	são	são	PROPN
dti-1319	6	14	paulo	paulo	PROPN
dti-1319	6	15	,	,	PUNCT
dti-1319	6	16	sp	sp	NOUN
dti-1319	6	17	,	,	PUNCT
dti-1319	6	18	brazil	brazil	PROPN
dti-1319	6	19	.	.	PUNCT
dti-1319	7	1	present	present	ADJ
dti-1319	7	2	address	address	NOUN
dti-1319	7	3	4departamento	4departamento	NUM
dti-1319	7	4	de	de	X
dti-1319	7	5	fisiologia	fisiologia	PROPN
dti-1319	7	6	e	e	PROPN
dti-1319	7	7	biofísica	biofísica	PROPN
dti-1319	7	8	,	,	PUNCT
dti-1319	7	9	instituto	instituto	PROPN
dti-1319	7	10	de	de	PROPN
dti-1319	7	11	ciências	ciências	PROPN
dti-1319	7	12	biomédicas	biomédicas	PROPN
dti-1319	7	13	,	,	PUNCT
dti-1319	7	14	universidade	universidade	PROPN
dti-1319	7	15	de	de	PROPN
dti-1319	7	16	são	são	PROPN
dti-1319	7	17	paulo	paulo	PROPN
dti-1319	7	18	,	,	PUNCT
dti-1319	7	19	05508	05508	NUM
dti-1319	7	20	-	-	SYM
dti-1319	7	21	900	900	NUM
dti-1319	7	22	são	são	NOUN
dti-1319	7	23	paulo	paulo	NOUN
dti-1319	7	24	,	,	PUNCT
dti-1319	7	25	sp	sp	NOUN
dti-1319	7	26	,	,	PUNCT
dti-1319	7	27	brazil	brazil	PROPN
dti-1319	7	28	.	.	PUNCT
dti-1319	8	1	abstract	abstract	ADJ
dti-1319	8	2	:	:	PUNCT
dti-1319	8	3	the	the	DET
dti-1319	8	4	notorious	notorious	ADJ
dti-1319	8	5	biotechnological	biotechnological	ADJ
dti-1319	8	6	advance	advance	NOUN
dti-1319	8	7	of	of	ADP
dti-1319	8	8	the	the	DET
dti-1319	8	9	last	last	ADJ
dti-1319	8	10	few	few	ADJ
dti-1319	8	11	decades	decade	NOUN
dti-1319	8	12	has	have	AUX
dti-1319	8	13	allowed	allow	VERB
dti-1319	8	14	the	the	DET
dti-1319	8	15	development	development	NOUN
dti-1319	8	16	of	of	ADP
dti-1319	8	17	experimental	experimental	ADJ
dti-1319	8	18	methods	method	NOUN
dti-1319	8	19	for	for	ADP
dti-1319	8	20	understanding	understand	VERB
dti-1319	8	21	molecular	molecular	ADJ
dti-1319	8	22	mechanisms	mechanism	NOUN
dti-1319	8	23	of	of	ADP
dti-1319	8	24	genes	gene	NOUN
dti-1319	8	25	and	and	CCONJ
dti-1319	8	26	new	new	ADJ
dti-1319	8	27	therapeutic	therapeutic	ADJ
dti-1319	8	28	approaches	approach	NOUN
dti-1319	8	29	.	.	PUNCT
dti-1319	9	1	gene	gene	NOUN
dti-1319	9	2	therapy	therapy	NOUN
dti-1319	9	3	is	be	AUX
dti-1319	9	4	maturing	mature	VERB
dti-1319	9	5	into	into	ADP
dti-1319	9	6	a	a	DET
dti-1319	9	7	viable	viable	ADJ
dti-1319	9	8	,	,	PUNCT
dti-1319	9	9	practical	practical	ADJ
dti-1319	9	10	method	method	NOUN
dti-1319	9	11	with	with	ADP
dti-1319	9	12	the	the	DET
dti-1319	9	13	potential	potential	NOUN
dti-1319	9	14	to	to	PART
dti-1319	9	15	cure	cure	VERB
dti-1319	9	16	a	a	DET
dti-1319	9	17	variety	variety	NOUN
dti-1319	9	18	of	of	ADP
dti-1319	9	19	human	human	ADJ
dti-1319	9	20	illnesses	illness	NOUN
dti-1319	9	21	.	.	PUNCT
dti-1319	10	1	some	some	DET
dti-1319	10	2	nucleic	nucleic	ADJ
dti-1319	10	3	-	-	PUNCT
dti-1319	10	4	acid	acid	NOUN
dti-1319	10	5	-	-	PUNCT
dti-1319	10	6	based	base	VERB
dti-1319	10	7	drugs	drug	NOUN
dti-1319	10	8	are	be	AUX
dti-1319	10	9	now	now	ADV
dti-1319	10	10	available	available	ADJ
dti-1319	10	11	for	for	ADP
dti-1319	10	12	controlling	control	VERB
dti-1319	10	13	the	the	DET
dti-1319	10	14	progression	progression	NOUN
dti-1319	10	15	of	of	ADP
dti-1319	10	16	genetic	genetic	ADJ
dti-1319	10	17	diseases	disease	NOUN
dti-1319	10	18	by	by	ADP
dti-1319	10	19	inhibiting	inhibit	VERB
dti-1319	10	20	gene	gene	NOUN
dti-1319	10	21	expression	expression	NOUN
dti-1319	10	22	or	or	CCONJ
dti-1319	10	23	the	the	DET
dti-1319	10	24	activity	activity	NOUN
dti-1319	10	25	of	of	ADP
dti-1319	10	26	their	their	PRON
dti-1319	10	27	gene	gene	NOUN
dti-1319	10	28	products	product	NOUN
dti-1319	10	29	.	.	PUNCT
dti-1319	11	1	new	new	ADJ
dti-1319	11	2	therapeutic	therapeutic	ADJ
dti-1319	11	3	strategies	strategy	NOUN
dti-1319	11	4	employ	employ	VERB
dti-1319	11	5	a	a	DET
dti-1319	11	6	wide	wide	ADJ
dti-1319	11	7	range	range	NOUN
dti-1319	11	8	of	of	ADP
dti-1319	11	9	molecular	molecular	ADJ
dti-1319	11	10	tools	tool	NOUN
dti-1319	11	11	such	such	ADJ
dti-1319	11	12	as	as	ADP
dti-1319	11	13	bacterial	bacterial	ADJ
dti-1319	11	14	plasmids	plasmid	NOUN
dti-1319	11	15	containing	contain	VERB
dti-1319	11	16	transgenic	transgenic	NOUN
dti-1319	11	17	inserts	insert	NOUN
dti-1319	11	18	,	,	PUNCT
dti-1319	11	19	rna	rna	NOUN
dti-1319	11	20	interference	interference	NOUN
dti-1319	11	21	and	and	CCONJ
dti-1319	11	22	aptamers	aptamer	NOUN
dti-1319	11	23	.	.	PUNCT
dti-1319	12	1	a	a	DET
dti-1319	12	2	nucleic	nucleic	ADJ
dti-1319	12	3	-	-	PUNCT
dti-1319	12	4	acid	acid	NOUN
dti-1319	12	5	based	base	VERB
dti-1319	12	6	constitution	constitution	NOUN
dti-1319	12	7	confers	confer	VERB
dti-1319	12	8	a	a	DET
dti-1319	12	9	lower	low	ADJ
dti-1319	12	10	immunogenic	immunogenic	ADJ
dti-1319	12	11	potential	potential	NOUN
dti-1319	12	12	and	and	CCONJ
dti-1319	12	13	as	as	ADP
dti-1319	12	14	result	result	NOUN
dti-1319	12	15	of	of	ADP
dti-1319	12	16	the	the	DET
dti-1319	12	17	high	high	ADJ
dti-1319	12	18	stringency	stringency	NOUN
dti-1319	12	19	selection	selection	NOUN
dti-1319	12	20	of	of	ADP
dti-1319	12	21	large	large	ADJ
dti-1319	12	22	molecular	molecular	ADJ
dti-1319	12	23	variety	variety	NOUN
dti-1319	12	24	,	,	PUNCT
dti-1319	12	25	these	these	DET
dti-1319	12	26	drugs	drug	NOUN
dti-1319	12	27	have	have	VERB
dti-1319	12	28	high	high	ADJ
dti-1319	12	29	affi	affi	PROPN
dti-1319	12	30	nity	nity	NOUN
dti-1319	12	31	and	and	CCONJ
dti-1319	12	32	selectivity	selectivity	NOUN
dti-1319	12	33	for	for	ADP
dti-1319	12	34	their	their	PRON
dti-1319	12	35	targets	target	NOUN
dti-1319	12	36	.	.	PUNCT
dti-1319	13	1	however	however	ADV
dti-1319	13	2	,	,	PUNCT
dti-1319	13	3	nucleic	nucleic	ADJ
dti-1319	13	4	acids	acid	NOUN
dti-1319	13	5	have	have	VERB
dti-1319	13	6	poor	poor	ADJ
dti-1319	13	7	biostability	biostability	NOUN
dti-1319	13	8	thus	thus	ADV
dti-1319	13	9	requiring	require	VERB
dti-1319	13	10	chemical	chemical	NOUN
dti-1319	13	11	modifi	modifi	NOUN
dti-1319	13	12	cations	cation	NOUN
dti-1319	13	13	and	and	CCONJ
dti-1319	13	14	delivery	delivery	NOUN
dti-1319	13	15	systems	system	NOUN
dti-1319	13	16	to	to	PART
dti-1319	13	17	maintain	maintain	VERB
dti-1319	13	18	their	their	PRON
dti-1319	13	19	activity	activity	NOUN
dti-1319	13	20	and	and	CCONJ
dti-1319	13	21	ease	ease	VERB
dti-1319	13	22	their	their	PRON
dti-1319	13	23	cellular	cellular	ADJ
dti-1319	13	24	internalization	internalization	NOUN
dti-1319	13	25	.	.	PUNCT
dti-1319	14	1	this	this	DET
dti-1319	14	2	review	review	NOUN
dti-1319	14	3	discusses	discuss	VERB
dti-1319	14	4	some	some	PRON
dti-1319	14	5	of	of	ADP
dti-1319	14	6	the	the	DET
dti-1319	14	7	mechanisms	mechanism	NOUN
dti-1319	14	8	of	of	ADP
dti-1319	14	9	action	action	NOUN
dti-1319	14	10	and	and	CCONJ
dti-1319	14	11	the	the	DET
dti-1319	14	12	application	application	NOUN
dti-1319	14	13	of	of	ADP
dti-1319	14	14	therapies	therapy	NOUN
dti-1319	14	15	based	base	VERB
dti-1319	14	16	on	on	ADP
dti-1319	14	17	nucleic	nucleic	ADJ
dti-1319	14	18	acids	acid	NOUN
dti-1319	14	19	such	such	ADJ
dti-1319	14	20	as	as	ADP
dti-1319	14	21	aptamers	aptamer	NOUN
dti-1319	14	22	and	and	CCONJ
dti-1319	14	23	rna	rna	NOUN
dti-1319	14	24	interference	interference	NOUN
dti-1319	14	25	as	as	ADV
dti-1319	14	26	well	well	ADV
dti-1319	14	27	as	as	ADP
dti-1319	14	28	platforms	platform	NOUN
dti-1319	14	29	for	for	ADP
dti-1319	14	30	cellular	cellular	ADJ
dti-1319	14	31	uptake	uptake	NOUN
dti-1319	14	32	and	and	CCONJ
dti-1319	14	33	intracellular	intracellular	ADJ
dti-1319	14	34	delivery	delivery	NOUN
dti-1319	14	35	of	of	ADP
dti-1319	14	36	therapeutic	therapeutic	ADJ
dti-1319	14	37	oligonucleotides	oligonucleotide	NOUN
dti-1319	14	38	and	and	CCONJ
dti-1319	14	39	their	their	PRON
dti-1319	14	40	trade	trade	NOUN
dti-1319	14	41	-	-	PUNCT
dti-1319	14	42	offs	off	NOUN
dti-1319	14	43	.	.	PUNCT
dti-1319	15	1	keywords	keyword	NOUN
dti-1319	15	2	:	:	PUNCT
dti-1319	15	3	aptamers	aptamer	NOUN
dti-1319	15	4	,	,	PUNCT
dti-1319	15	5	rna	rna	NOUN
dti-1319	15	6	interference	interference	NOUN
dti-1319	15	7	(	(	PUNCT
dti-1319	15	8	rnai	rnai	PROPN
dti-1319	15	9	)	)	PUNCT
dti-1319	15	10	,	,	PUNCT
dti-1319	15	11	drug	drug	NOUN
dti-1319	15	12	delivery	delivery	NOUN
dti-1319	15	13	systems	system	NOUN
dti-1319	15	14	,	,	PUNCT
dti-1319	15	15	nucleic	nucleic	ADJ
dti-1319	15	16	-	-	PUNCT
dti-1319	15	17	acid	acid	NOUN
dti-1319	15	18	-	-	PUNCT
dti-1319	15	19	based	base	VERB
dti-1319	15	20	drugs	drug	NOUN
dti-1319	15	21	.	.	PUNCT
dti-1319	16	1	introduction	introduction	NOUN
dti-1319	16	2	the	the	DET
dti-1319	16	3	discovery	discovery	NOUN
dti-1319	16	4	of	of	ADP
dti-1319	16	5	the	the	DET
dti-1319	16	6	dna	dna	PROPN
dti-1319	16	7	molecule	molecule	NOUN
dti-1319	16	8	was	be	AUX
dti-1319	16	9	one	one	NUM
dti-1319	16	10	of	of	ADP
dti-1319	16	11	the	the	DET
dti-1319	16	12	most	most	ADV
dti-1319	16	13	important	important	ADJ
dti-1319	16	14	achievements	achievement	NOUN
dti-1319	16	15	in	in	ADP
dti-1319	16	16	the	the	DET
dti-1319	16	17	understanding	understanding	NOUN
dti-1319	16	18	of	of	ADP
dti-1319	16	19	the	the	DET
dti-1319	16	20	fundamental	fundamental	ADJ
dti-1319	16	21	basis	basis	NOUN
dti-1319	16	22	of	of	ADP
dti-1319	16	23	life	life	NOUN
dti-1319	16	24	and	and	CCONJ
dti-1319	16	25	now	now	ADV
dti-1319	16	26	its	its	PRON
dti-1319	16	27	untapped	untapped	ADJ
dti-1319	16	28	therapeutic	therapeutic	ADJ
dti-1319	16	29	potential	potential	NOUN
dti-1319	16	30	is	be	AUX
dti-1319	16	31	being	be	AUX
dti-1319	16	32	revealed	reveal	VERB
dti-1319	16	33	.	.	PUNCT
dti-1319	17	1	therapies	therapy	NOUN
dti-1319	17	2	based	base	VERB
dti-1319	17	3	on	on	ADP
dti-1319	17	4	nucleic	nucleic	ADJ
dti-1319	17	5	acids	acid	NOUN
dti-1319	17	6	(	(	PUNCT
dti-1319	17	7	nas	nas	PROPN
dti-1319	17	8	)	)	PUNCT
dti-1319	17	9	including	include	VERB
dti-1319	17	10	plasmids	plasmid	NOUN
dti-1319	17	11	containing	contain	VERB
dti-1319	17	12	transgenes	transgene	NOUN
dti-1319	17	13	used	use	VERB
dti-1319	17	14	in	in	ADP
dti-1319	17	15	gene	gene	NOUN
dti-1319	17	16	therapy	therapy	NOUN
dti-1319	17	17	,	,	PUNCT
dti-1319	17	18	antisense	antisense	NOUN
dti-1319	17	19	and	and	CCONJ
dti-1319	17	20	antigene	antigene	ADJ
dti-1319	17	21	oligonucleotides	oligonucleotide	NOUN
dti-1319	17	22	,	,	PUNCT
dti-1319	17	23	ribozymes	ribozyme	NOUN
dti-1319	17	24	,	,	PUNCT
dti-1319	17	25	dnazymes	dnazyme	NOUN
dti-1319	17	26	,	,	PUNCT
dti-1319	17	27	dna	dna	NOUN
dti-1319	17	28	and	and	CCONJ
dti-1319	17	29	rna	rna	NOUN
dti-1319	17	30	aptamers	aptamer	NOUN
dti-1319	17	31	and	and	CCONJ
dti-1319	17	32	small	small	ADJ
dti-1319	17	33	interfering	interfering	NOUN
dti-1319	17	34	rnas	rna	NOUN
dti-1319	17	35	,	,	PUNCT
dti-1319	17	36	have	have	AUX
dti-1319	17	37	been	be	AUX
dti-1319	17	38	developed	develop	VERB
dti-1319	17	39	over	over	ADP
dti-1319	17	40	the	the	DET
dti-1319	17	41	past	past	ADJ
dti-1319	17	42	couple	couple	NOUN
dti-1319	17	43	of	of	ADP
dti-1319	17	44	decades	decade	NOUN
dti-1319	17	45	(	(	PUNCT
dti-1319	17	46	crooke	crooke	NOUN
dti-1319	17	47	,	,	PUNCT
dti-1319	17	48	1998	1998	NUM
dti-1319	17	49	;	;	PUNCT
dti-1319	17	50	stull	stull	NOUN
dti-1319	17	51	and	and	CCONJ
dti-1319	17	52	szoka	szoka	VERB
dti-1319	17	53	,	,	PUNCT
dti-1319	17	54	1995	1995	NUM
dti-1319	17	55	;	;	PUNCT
dti-1319	17	56	patil	patil	PROPN
dti-1319	17	57	et	et	PROPN
dti-1319	17	58	al	al	PROPN
dti-1319	17	59	.	.	PROPN
dti-1319	17	60	2005	2005	NUM
dti-1319	17	61	;	;	PUNCT
dti-1319	17	62	ulrich	ulrich	PROPN
dti-1319	17	63	et	et	PROPN
dti-1319	17	64	al	al	PROPN
dti-1319	17	65	.	.	PROPN
dti-1319	17	66	2006	2006	NUM
dti-1319	17	67	)	)	PUNCT
dti-1319	17	68	.	.	PUNCT
dti-1319	18	1	although	although	SCONJ
dti-1319	18	2	most	most	ADJ
dti-1319	18	3	na	na	NOUN
dti-1319	18	4	-	-	PUNCT
dti-1319	18	5	based	base	VERB
dti-1319	18	6	drugs	drug	NOUN
dti-1319	18	7	are	be	AUX
dti-1319	18	8	in	in	ADP
dti-1319	18	9	the	the	DET
dti-1319	18	10	early	early	ADJ
dti-1319	18	11	stages	stage	NOUN
dti-1319	18	12	of	of	ADP
dti-1319	18	13	clinical	clinical	ADJ
dti-1319	18	14	trials	trial	NOUN
dti-1319	18	15	,	,	PUNCT
dti-1319	18	16	this	this	DET
dti-1319	18	17	molecule	molecule	NOUN
dti-1319	18	18	class	class	NOUN
dti-1319	18	19	has	have	AUX
dti-1319	18	20	emerged	emerge	VERB
dti-1319	18	21	during	during	ADP
dti-1319	18	22	recent	recent	ADJ
dti-1319	18	23	years	year	NOUN
dti-1319	18	24	as	as	ADP
dti-1319	18	25	promising	promise	VERB
dti-1319	18	26	drug	drug	NOUN
dti-1319	18	27	candidates	candidate	NOUN
dti-1319	18	28	able	able	ADJ
dti-1319	18	29	to	to	PART
dti-1319	18	30	act	act	VERB
dti-1319	18	31	in	in	ADP
dti-1319	18	32	a	a	DET
dti-1319	18	33	large	large	ADJ
dti-1319	18	34	range	range	NOUN
dti-1319	18	35	of	of	ADP
dti-1319	18	36	diseases	disease	NOUN
dti-1319	18	37	including	include	VERB
dti-1319	18	38	aids	aids	PROPN
dti-1319	18	39	,	,	PUNCT
dti-1319	18	40	cancer	cancer	NOUN
dti-1319	18	41	and	and	CCONJ
dti-1319	18	42	neurological	neurological	ADJ
dti-1319	18	43	and	and	CCONJ
dti-1319	18	44	cardiovascular	cardiovascular	ADJ
dti-1319	18	45	disorders	disorder	NOUN
dti-1319	18	46	(	(	PUNCT
dti-1319	18	47	stull	stull	NOUN
dti-1319	18	48	and	and	CCONJ
dti-1319	18	49	szoka	szoka	VERB
dti-1319	18	50	,	,	PUNCT
dti-1319	18	51	1995	1995	NUM
dti-1319	18	52	;	;	PUNCT
dti-1319	18	53	patil	patil	PROPN
dti-1319	18	54	et	et	PROPN
dti-1319	18	55	al	al	PROPN
dti-1319	18	56	.	.	PROPN
dti-1319	18	57	2005	2005	NUM
dti-1319	18	58	;	;	PUNCT
dti-1319	18	59	ulrich	ulrich	PROPN
dti-1319	18	60	et	et	PROPN
dti-1319	18	61	al	al	PROPN
dti-1319	18	62	.	.	PROPN
dti-1319	18	63	2006	2006	NUM
dti-1319	18	64	)	)	PUNCT
dti-1319	18	65	.	.	PUNCT
dti-1319	19	1	the	the	DET
dti-1319	19	2	sequencing	sequencing	NOUN
dti-1319	19	3	of	of	ADP
dti-1319	19	4	the	the	DET
dti-1319	19	5	human	human	ADJ
dti-1319	19	6	genome	genome	NOUN
dti-1319	19	7	and	and	CCONJ
dti-1319	19	8	the	the	DET
dti-1319	19	9	transcriptome	transcriptome	NOUN
dti-1319	19	10	and	and	CCONJ
dti-1319	19	11	proteome	proteome	ADJ
dti-1319	19	12	projects	project	NOUN
dti-1319	19	13	are	be	AUX
dti-1319	19	14	providing	provide	VERB
dti-1319	19	15	additional	additional	ADJ
dti-1319	19	16	platforms	platform	NOUN
dti-1319	19	17	for	for	ADP
dti-1319	19	18	the	the	DET
dti-1319	19	19	advancement	advancement	NOUN
dti-1319	19	20	of	of	ADP
dti-1319	19	21	nabased	nabased	ADJ
dti-1319	19	22	therapies	therapy	NOUN
dti-1319	19	23	by	by	ADP
dti-1319	19	24	supplying	supply	VERB
dti-1319	19	25	new	new	ADJ
dti-1319	19	26	targets	target	NOUN
dti-1319	19	27	for	for	ADP
dti-1319	19	28	the	the	DET
dti-1319	19	29	design	design	NOUN
dti-1319	19	30	,	,	PUNCT
dti-1319	19	31	screening	screening	NOUN
dti-1319	19	32	and	and	CCONJ
dti-1319	19	33	selection	selection	NOUN
dti-1319	19	34	of	of	ADP
dti-1319	19	35	drugs	drug	NOUN
dti-1319	19	36	.	.	PUNCT
dti-1319	20	1	one	one	NUM
dti-1319	20	2	of	of	ADP
dti-1319	20	3	the	the	DET
dti-1319	20	4	most	most	ADV
dti-1319	20	5	signifi	signifi	NOUN
dti-1319	20	6	ca	can	AUX
dti-1319	20	7	nt	not	PART
dti-1319	20	8	advantages	advantage	NOUN
dti-1319	20	9	of	of	ADP
dti-1319	20	10	na	na	NOUN
dti-1319	20	11	-	-	PUNCT
dti-1319	20	12	based	base	VERB
dti-1319	20	13	drugs	drug	NOUN
dti-1319	20	14	over	over	ADP
dti-1319	20	15	conventional	conventional	ADJ
dti-1319	20	16	pharmaceutical	pharmaceutical	ADJ
dti-1319	20	17	drugs	drug	NOUN
dti-1319	20	18	is	be	AUX
dti-1319	20	19	its	its	PRON
dti-1319	20	20	high	high	ADJ
dti-1319	20	21	selectivity	selectivity	NOUN
dti-1319	20	22	towards	towards	ADP
dti-1319	20	23	its	its	PRON
dti-1319	20	24	molecular	molecular	ADJ
dti-1319	20	25	targets	target	NOUN
dti-1319	20	26	resulting	result	VERB
dti-1319	20	27	in	in	ADP
dti-1319	20	28	very	very	ADV
dti-1319	20	29	specifi	specifi	PROPN
dti-1319	20	30	c	c	PROPN
dti-1319	20	31	physiological	physiological	ADJ
dti-1319	20	32	action	action	NOUN
dti-1319	20	33	.	.	PUNCT
dti-1319	21	1	these	these	DET
dti-1319	21	2	drugs	drug	NOUN
dti-1319	21	3	can	can	AUX
dti-1319	21	4	be	be	AUX
dti-1319	21	5	used	use	VERB
dti-1319	21	6	to	to	PART
dti-1319	21	7	investigate	investigate	VERB
dti-1319	21	8	the	the	DET
dti-1319	21	9	genetic	genetic	ADJ
dti-1319	21	10	disease	disease	NOUN
dti-1319	21	11	condition	condition	NOUN
dti-1319	21	12	or	or	CCONJ
dti-1319	21	13	used	use	VERB
dti-1319	21	14	in	in	ADP
dti-1319	21	15	prophylactic	prophylactic	ADJ
dti-1319	21	16	measures	measure	NOUN
dti-1319	21	17	,	,	PUNCT
dti-1319	21	18	thereby	thereby	ADV
dti-1319	21	19	preventing	prevent	VERB
dti-1319	21	20	disease	disease	NOUN
dti-1319	21	21	progression	progression	NOUN
dti-1319	21	22	and/or	and/or	CCONJ
dti-1319	21	23	complications	complication	NOUN
dti-1319	21	24	in	in	ADP
dti-1319	21	25	its	its	PRON
dti-1319	21	26	early	early	ADJ
dti-1319	21	27	stages	stage	NOUN
dti-1319	21	28	.	.	PUNCT
dti-1319	22	1	for	for	ADP
dti-1319	22	2	instance	instance	NOUN
dti-1319	22	3	,	,	PUNCT
dti-1319	22	4	gene	gene	NOUN
dti-1319	22	5	therapy	therapy	NOUN
dti-1319	22	6	usually	usually	ADV
dti-1319	22	7	involves	involve	VERB
dti-1319	22	8	the	the	DET
dti-1319	22	9	correction	correction	NOUN
dti-1319	22	10	of	of	ADP
dti-1319	22	11	a	a	DET
dti-1319	22	12	malfunctioning	malfunction	VERB
dti-1319	22	13	gene	gene	NOUN
dti-1319	22	14	by	by	ADP
dti-1319	22	15	the	the	DET
dti-1319	22	16	introduction	introduction	NOUN
dti-1319	22	17	and	and	CCONJ
dti-1319	22	18	expression	expression	NOUN
dti-1319	22	19	of	of	ADP
dti-1319	22	20	its	its	PRON
dti-1319	22	21	correct	correct	ADJ
dti-1319	22	22	copy	copy	NOUN
dti-1319	22	23	,	,	PUNCT
dti-1319	22	24	thus	thus	ADV
dti-1319	22	25	resulting	result	VERB
dti-1319	22	26	in	in	ADP
dti-1319	22	27	a	a	DET
dti-1319	22	28	corrected	correct	VERB
dti-1319	22	29	protein	protein	NOUN
dti-1319	22	30	product	product	NOUN
dti-1319	22	31	.	.	PUNCT
dti-1319	23	1	similarly	similarly	ADV
dti-1319	23	2	,	,	PUNCT
dti-1319	23	3	na	na	NOUN
dti-1319	23	4	-	-	PUNCT
dti-1319	23	5	based	base	VERB
dti-1319	23	6	drugs	drug	NOUN
dti-1319	23	7	involved	involve	VERB
dti-1319	23	8	in	in	ADP
dti-1319	23	9	gene	gene	NOUN
dti-1319	23	10	ablation	ablation	NOUN
dti-1319	23	11	turn	turn	VERB
dti-1319	23	12	off	off	ADP
dti-1319	23	13	only	only	ADV
dti-1319	23	14	selected	select	VERB
dti-1319	23	15	genes	gene	NOUN
dti-1319	23	16	,	,	PUNCT
dti-1319	23	17	guaranteeing	guarantee	VERB
dti-1319	23	18	specifi	specifi	PROPN
dti-1319	23	19	c	c	PROPN
dti-1319	23	20	control	control	NOUN
dti-1319	23	21	of	of	ADP
dti-1319	23	22	the	the	DET
dti-1319	23	23	disease	disease	NOUN
dti-1319	23	24	state	state	NOUN
dti-1319	23	25	.	.	PUNCT
dti-1319	24	1	thus	thus	ADV
dti-1319	24	2	,	,	PUNCT
dti-1319	24	3	at	at	ADP
dti-1319	24	4	least	least	ADJ
dti-1319	24	5	theoretically	theoretically	ADV
dti-1319	24	6	,	,	PUNCT
dti-1319	24	7	the	the	DET
dti-1319	24	8	use	use	NOUN
dti-1319	24	9	of	of	ADP
dti-1319	24	10	na	na	NOUN
dti-1319	24	11	-	-	PUNCT
dti-1319	24	12	based	base	VERB
dti-1319	24	13	therapies	therapy	NOUN
dti-1319	24	14	can	can	AUX
dti-1319	24	15	result	result	VERB
dti-1319	24	16	in	in	ADP
dti-1319	24	17	null	null	ADJ
dti-1319	24	18	or	or	CCONJ
dti-1319	24	19	minimal	minimal	ADJ
dti-1319	24	20	collateral	collateral	ADJ
dti-1319	24	21	effects	effect	NOUN
dti-1319	24	22	when	when	SCONJ
dti-1319	24	23	compared	compare	VERB
dti-1319	24	24	to	to	ADP
dti-1319	24	25	conventional	conventional	ADJ
dti-1319	24	26	,	,	PUNCT
dti-1319	24	27	often	often	ADV
dti-1319	24	28	less	less	ADV
dti-1319	24	29	specifi	specifi	PROPN
dti-1319	24	30	c	c	NOUN
dti-1319	24	31	,	,	PUNCT
dti-1319	24	32	pharmaceutical	pharmaceutical	ADJ
dti-1319	24	33	drugs	drug	NOUN
dti-1319	24	34	.	.	PUNCT
dti-1319	25	1	however	however	ADV
dti-1319	25	2	,	,	PUNCT
dti-1319	25	3	the	the	DET
dti-1319	25	4	effects	effect	NOUN
dti-1319	25	5	of	of	ADP
dti-1319	25	6	na	na	ADP
dti-1319	25	7	drugs	drug	NOUN
dti-1319	25	8	on	on	ADP
dti-1319	25	9	human	human	ADJ
dti-1319	25	10	exposition	exposition	NOUN
dti-1319	25	11	must	must	AUX
dti-1319	25	12	be	be	AUX
dti-1319	25	13	completely	completely	ADV
dti-1319	25	14	understood	understand	VERB
dti-1319	25	15	,	,	PUNCT
dti-1319	25	16	with	with	ADP
dti-1319	25	17	emphasis	emphasis	NOUN
dti-1319	25	18	to	to	ADP
dti-1319	25	19	unforeseen	unforeseen	ADJ
dti-1319	25	20	long	long	ADJ
dti-1319	25	21	-	-	PUNCT
dti-1319	25	22	term	term	NOUN
dti-1319	25	23	effects	effect	NOUN
dti-1319	25	24	.	.	PUNCT
dti-1319	26	1	there	there	PRON
dti-1319	26	2	is	be	VERB
dti-1319	26	3	yet	yet	ADV
dti-1319	26	4	little	little	ADJ
dti-1319	26	5	knowledge	knowledge	NOUN
dti-1319	26	6	about	about	ADP
dti-1319	26	7	pharmacokinetics	pharmacokinetic	NOUN
dti-1319	26	8	of	of	ADP
dti-1319	26	9	na	na	NOUN
dti-1319	26	10	-	-	PUNCT
dti-1319	26	11	based	base	VERB
dti-1319	26	12	drugs	drug	NOUN
dti-1319	26	13	.	.	PUNCT
dti-1319	27	1	the	the	DET
dti-1319	27	2	greatest	great	ADJ
dti-1319	27	3	challenge	challenge	NOUN
dti-1319	27	4	facing	face	VERB
dti-1319	27	5	the	the	DET
dti-1319	27	6	therapeutic	therapeutic	ADJ
dti-1319	27	7	utility	utility	NOUN
dti-1319	27	8	of	of	ADP
dti-1319	27	9	nas	nas	NOUN
dti-1319	27	10	is	be	AUX
dti-1319	27	11	to	to	PART
dti-1319	27	12	overcome	overcome	VERB
dti-1319	27	13	the	the	DET
dti-1319	27	14	low	low	ADJ
dti-1319	27	15	cellular	cellular	ADJ
dti-1319	27	16	absorption	absorption	NOUN
dti-1319	27	17	inherent	inherent	ADJ
dti-1319	27	18	to	to	ADP
dti-1319	27	19	their	their	PRON
dti-1319	27	20	highly	highly	ADV
dti-1319	27	21	polar	polar	ADJ
dti-1319	27	22	molecular	molecular	ADJ
dti-1319	27	23	structure	structure	NOUN
dti-1319	27	24	.	.	PUNCT
dti-1319	28	1	the	the	DET
dti-1319	28	2	innate	innate	ADJ
dti-1319	28	3	ability	ability	NOUN
dti-1319	28	4	of	of	ADP
dti-1319	28	5	these	these	DET
dti-1319	28	6	drugs	drug	NOUN
dti-1319	28	7	to	to	PART
dti-1319	28	8	cross	cross	VERB
dti-1319	28	9	membranes	membrane	NOUN
dti-1319	28	10	is	be	AUX
dti-1319	28	11	minimal	minimal	ADJ
dti-1319	28	12	in	in	ADP
dti-1319	28	13	normal	normal	ADJ
dti-1319	28	14	circumstances	circumstance	NOUN
dti-1319	28	15	.	.	PUNCT
dti-1319	29	1	in	in	ADP
dti-1319	29	2	addition	addition	NOUN
dti-1319	29	3	,	,	PUNCT
dti-1319	29	4	their	their	PRON
dti-1319	29	5	low	low	ADJ
dti-1319	29	6	biostability	biostability	NOUN
dti-1319	29	7	184	184	NUM
dti-1319	29	8	ulrich	ulrich	PROPN
dti-1319	29	9	et	et	PROPN
dti-1319	29	10	al	al	PROPN
dti-1319	29	11	drug	drug	PROPN
dti-1319	29	12	target	target	NOUN
dti-1319	29	13	insights	insight	VERB
dti-1319	29	14	2007:2	2007:2	NUM
dti-1319	29	15	results	result	NOUN
dti-1319	29	16	in	in	ADP
dti-1319	29	17	unpredictable	unpredictable	ADJ
dti-1319	29	18	pharmacokinetics	pharmacokinetic	NOUN
dti-1319	29	19	.	.	PUNCT
dti-1319	30	1	na	na	NOUN
dti-1319	30	2	molecules	molecule	NOUN
dti-1319	30	3	that	that	PRON
dti-1319	30	4	happen	happen	VERB
dti-1319	30	5	to	to	PART
dti-1319	30	6	enter	enter	VERB
dti-1319	30	7	the	the	DET
dti-1319	30	8	cell	cell	NOUN
dti-1319	30	9	are	be	AUX
dti-1319	30	10	subsequently	subsequently	ADV
dti-1319	30	11	subjected	subject	VERB
dti-1319	30	12	to	to	ADP
dti-1319	30	13	intracellular	intracellular	ADJ
dti-1319	30	14	degradation	degradation	NOUN
dti-1319	30	15	by	by	ADP
dti-1319	30	16	nucleases	nuclease	NOUN
dti-1319	30	17	effectively	effectively	ADV
dti-1319	30	18	narrowing	narrow	VERB
dti-1319	30	19	the	the	DET
dti-1319	30	20	drug	drug	NOUN
dti-1319	30	21	’s	’s	PART
dti-1319	30	22	activity	activity	NOUN
dti-1319	30	23	time	time	NOUN
dti-1319	30	24	-	-	PUNCT
dti-1319	30	25	span	span	NOUN
dti-1319	30	26	.	.	PUNCT
dti-1319	31	1	the	the	DET
dti-1319	31	2	fi	fi	NOUN
dti-1319	31	3	rst	rst	ADJ
dti-1319	31	4	na	na	NOUN
dti-1319	31	5	-	-	PUNCT
dti-1319	31	6	drug	drug	NOUN
dti-1319	31	7	approved	approve	VERB
dti-1319	31	8	in	in	ADP
dti-1319	31	9	november	november	PROPN
dti-1319	31	10	1998	1998	NUM
dti-1319	31	11	by	by	ADP
dti-1319	31	12	the	the	DET
dti-1319	31	13	fda	fda	PROPN
dti-1319	31	14	was	be	AUX
dti-1319	31	15	denominated	denominate	VERB
dti-1319	31	16	vitravene	vitravene	ADJ
dti-1319	31	17	®	®	NOUN
dti-1319	31	18	,	,	PUNCT
dti-1319	31	19	an	an	DET
dti-1319	31	20	oligonucleotide	oligonucleotide	NOUN
dti-1319	31	21	discovered	discover	VERB
dti-1319	31	22	by	by	ADP
dti-1319	31	23	isis	isis	NOUN
dti-1319	31	24	®	®	NOUN
dti-1319	31	25	as	as	ADP
dti-1319	31	26	antisense	antisense	NOUN
dti-1319	31	27	drug	drug	NOUN
dti-1319	31	28	for	for	ADP
dti-1319	31	29	the	the	DET
dti-1319	31	30	treatment	treatment	NOUN
dti-1319	31	31	of	of	ADP
dti-1319	31	32	cytomegalovirus	cytomegalovirus	NOUN
dti-1319	31	33	retinitis	retinitis	ADJ
dti-1319	31	34	in	in	ADP
dti-1319	31	35	aids	aids	NOUN
dti-1319	31	36	patients	patient	NOUN
dti-1319	31	37	(	(	PUNCT
dti-1319	31	38	perry	perry	NOUN
dti-1319	31	39	and	and	CCONJ
dti-1319	31	40	balfour	balfour	PROPN
dti-1319	31	41	,	,	PUNCT
dti-1319	31	42	1999	1999	NUM
dti-1319	31	43	)	)	PUNCT
dti-1319	31	44	.	.	PUNCT
dti-1319	32	1	vitravene	vitravene	PROPN
dti-1319	32	2	®	®	NOUN
dti-1319	32	3	was	be	AUX
dti-1319	32	4	marketed	market	VERB
dti-1319	32	5	by	by	ADP
dti-1319	32	6	novartis	novartis	NOUN
dti-1319	32	7	ophthalmics	ophthalmic	NOUN
dti-1319	32	8	®	®	NOUN
dti-1319	32	9	and	and	CCONJ
dti-1319	32	10	revealed	reveal	VERB
dti-1319	32	11	to	to	PART
dti-1319	32	12	be	be	AUX
dti-1319	32	13	a	a	DET
dti-1319	32	14	powerful	powerful	ADJ
dti-1319	32	15	aids	aid	NOUN
dti-1319	32	16	medication	medication	NOUN
dti-1319	32	17	.	.	PUNCT
dti-1319	33	1	in	in	ADP
dti-1319	33	2	preclinical	preclinical	ADJ
dti-1319	33	3	studies	study	NOUN
dti-1319	33	4	,	,	PUNCT
dti-1319	33	5	antisense	antisense	NOUN
dti-1319	33	6	inhibition	inhibition	NOUN
dti-1319	33	7	of	of	ADP
dti-1319	33	8	c	c	NOUN
dti-1319	33	9	-	-	PUNCT
dti-1319	33	10	raf	raf	PROPN
dti-1319	33	11	kinase	kinase	NOUN
dti-1319	33	12	was	be	AUX
dti-1319	33	13	associated	associate	VERB
dti-1319	33	14	with	with	ADP
dti-1319	33	15	a	a	DET
dti-1319	33	16	reduction	reduction	NOUN
dti-1319	33	17	in	in	ADP
dti-1319	33	18	the	the	DET
dti-1319	33	19	formation	formation	NOUN
dti-1319	33	20	of	of	ADP
dti-1319	33	21	new	new	ADJ
dti-1319	33	22	blood	blood	NOUN
dti-1319	33	23	vessels	vessel	NOUN
dti-1319	33	24	in	in	ADP
dti-1319	33	25	the	the	DET
dti-1319	33	26	eye	eye	NOUN
dti-1319	33	27	involved	involve	VERB
dti-1319	33	28	in	in	ADP
dti-1319	33	29	both	both	PRON
dti-1319	33	30	,	,	PUNCT
dti-1319	33	31	age	age	NOUN
dti-1319	33	32	-	-	PUNCT
dti-1319	33	33	related	relate	VERB
dti-1319	33	34	macular	macular	ADJ
dti-1319	33	35	degeneration	degeneration	NOUN
dti-1319	33	36	(	(	PUNCT
dti-1319	33	37	amd	amd	ADJ
dti-1319	33	38	)	)	PUNCT
dti-1319	33	39	and	and	CCONJ
dti-1319	33	40	diabetic	diabetic	ADJ
dti-1319	33	41	retinopathy	retinopathy	ADJ
dti-1319	33	42	(	(	PUNCT
dti-1319	33	43	danis	danis	NOUN
dti-1319	33	44	et	et	PROPN
dti-1319	33	45	al	al	PROPN
dti-1319	33	46	.	.	PROPN
dti-1319	33	47	2003	2003	NUM
dti-1319	33	48	)	)	PUNCT
dti-1319	33	49	.	.	PUNCT
dti-1319	34	1	the	the	DET
dti-1319	34	2	approval	approval	NOUN
dti-1319	34	3	of	of	ADP
dti-1319	34	4	this	this	DET
dti-1319	34	5	fi	fi	NOUN
dti-1319	34	6	rst	rst	ADJ
dti-1319	34	7	nucleic	nucleic	ADJ
dti-1319	34	8	-	-	PUNCT
dti-1319	34	9	acid	acid	NOUN
dti-1319	34	10	based	base	VERB
dti-1319	34	11	drug	drug	NOUN
dti-1319	34	12	serves	serve	VERB
dti-1319	34	13	as	as	ADP
dti-1319	34	14	an	an	DET
dti-1319	34	15	encouragement	encouragement	NOUN
dti-1319	34	16	for	for	SCONJ
dti-1319	34	17	scientists	scientist	NOUN
dti-1319	34	18	to	to	PART
dti-1319	34	19	further	far	ADV
dti-1319	34	20	use	use	VERB
dti-1319	34	21	selex	selex	PROPN
dti-1319	34	22	systematic	systematic	ADJ
dti-1319	34	23	evolution	evolution	NOUN
dti-1319	34	24	of	of	ADP
dti-1319	34	25	ligands	ligand	NOUN
dti-1319	34	26	by	by	ADP
dti-1319	34	27	exponential	exponential	ADJ
dti-1319	34	28	enrichment	enrichment	NOUN
dti-1319	34	29	and	and	CCONJ
dti-1319	34	30	rna	rna	NOUN
dti-1319	34	31	interference	interference	NOUN
dti-1319	34	32	(	(	PUNCT
dti-1319	34	33	rnai	rnai	NOUN
dti-1319	34	34	)	)	PUNCT
dti-1319	34	35	approaches	approach	NOUN
dti-1319	34	36	for	for	ADP
dti-1319	34	37	drug	drug	NOUN
dti-1319	34	38	development	development	NOUN
dti-1319	34	39	(	(	PUNCT
dti-1319	34	40	see	see	VERB
dti-1319	34	41	fig.1a	fig.1a	NOUN
dti-1319	34	42	for	for	ADP
dti-1319	34	43	a	a	DET
dti-1319	34	44	scheme	scheme	NOUN
dti-1319	34	45	of	of	ADP
dti-1319	34	46	oligonucleotide	oligonucleotide	ADJ
dti-1319	34	47	action	action	NOUN
dti-1319	34	48	on	on	ADP
dti-1319	34	49	gene	gene	NOUN
dti-1319	34	50	expression	expression	NOUN
dti-1319	34	51	and	and	CCONJ
dti-1319	34	52	protein	protein	NOUN
dti-1319	34	53	acivity	acivity	NOUN
dti-1319	34	54	)	)	PUNCT
dti-1319	34	55	.	.	PUNCT
dti-1319	35	1	nucleic	nucleic	ADJ
dti-1319	35	2	-	-	PUNCT
dti-1319	35	3	acid	acid	NOUN
dti-1319	35	4	based	base	VERB
dti-1319	35	5	therapies	therapy	NOUN
dti-1319	35	6	mechanisms	mechanism	NOUN
dti-1319	35	7	of	of	ADP
dti-1319	35	8	action	action	NOUN
dti-1319	35	9	small	small	ADJ
dti-1319	35	10	interfering	interfere	VERB
dti-1319	35	11	rnas	rna	NOUN
dti-1319	35	12	artifi	artifi	PROPN
dti-1319	35	13	cial	cial	ADJ
dti-1319	35	14	modulation	modulation	NOUN
dti-1319	35	15	of	of	ADP
dti-1319	35	16	gene	gene	NOUN
dti-1319	35	17	expression	expression	NOUN
dti-1319	35	18	is	be	AUX
dti-1319	35	19	mainly	mainly	ADV
dti-1319	35	20	based	base	VERB
dti-1319	35	21	on	on	ADP
dti-1319	35	22	the	the	DET
dti-1319	35	23	inhibition	inhibition	NOUN
dti-1319	35	24	of	of	ADP
dti-1319	35	25	gene	gene	NOUN
dti-1319	35	26	transcription	transcription	NOUN
dti-1319	35	27	or	or	CCONJ
dti-1319	35	28	mrna	mrna	PROPN
dti-1319	35	29	degradation	degradation	NOUN
dti-1319	35	30	.	.	PUNCT
dti-1319	36	1	the	the	DET
dti-1319	36	2	phenomenon	phenomenon	NOUN
dti-1319	36	3	of	of	ADP
dti-1319	36	4	rnai	rnai	PROPN
dti-1319	36	5	was	be	AUX
dti-1319	36	6	first	first	ADV
dti-1319	36	7	observed	observe	VERB
dti-1319	36	8	in	in	ADP
dti-1319	36	9	the	the	DET
dti-1319	36	10	nematode	nematode	NOUN
dti-1319	36	11	worm	worm	NOUN
dti-1319	36	12	caenorhabditis	caenorhabditis	PROPN
dti-1319	36	13	elegans	elegan	NOUN
dti-1319	36	14	in	in	ADP
dti-1319	36	15	response	response	NOUN
dti-1319	36	16	to	to	ADP
dti-1319	36	17	a	a	DET
dti-1319	36	18	doublestranded	doublestranded	ADJ
dti-1319	36	19	rna	rna	NOUN
dti-1319	36	20	(	(	PUNCT
dti-1319	36	21	dsrna	dsrna	NOUN
dti-1319	36	22	)	)	PUNCT
dti-1319	36	23	treatment	treatment	NOUN
dti-1319	36	24	which	which	PRON
dti-1319	36	25	resulted	result	VERB
dti-1319	36	26	in	in	ADP
dti-1319	36	27	sequence	sequence	NOUN
dti-1319	36	28	-	-	PUNCT
dti-1319	36	29	specifi	specifi	PROPN
dti-1319	36	30	c	c	PROPN
dti-1319	36	31	gene	gene	NOUN
dti-1319	36	32	silencing	silence	VERB
dti-1319	36	33	(	(	PUNCT
dti-1319	36	34	fire	fire	NOUN
dti-1319	36	35	et	et	PROPN
dti-1319	36	36	al	al	PROPN
dti-1319	36	37	.	.	PROPN
dti-1319	36	38	1998	1998	NUM
dti-1319	36	39	)	)	PUNCT
dti-1319	36	40	.	.	PUNCT
dti-1319	37	1	later	later	ADV
dti-1319	37	2	,	,	PUNCT
dti-1319	37	3	the	the	DET
dti-1319	37	4	same	same	ADJ
dti-1319	37	5	phenomenon	phenomenon	NOUN
dti-1319	37	6	was	be	AUX
dti-1319	37	7	observed	observe	VERB
dti-1319	37	8	in	in	ADP
dti-1319	37	9	a	a	DET
dti-1319	37	10	large	large	ADJ
dti-1319	37	11	variety	variety	NOUN
dti-1319	37	12	of	of	ADP
dti-1319	37	13	biological	biological	ADJ
dti-1319	37	14	systems	system	NOUN
dti-1319	37	15	including	include	VERB
dti-1319	37	16	several	several	ADJ
dti-1319	37	17	invertebrates	invertebrate	NOUN
dti-1319	37	18	and	and	CCONJ
dti-1319	37	19	,	,	PUNCT
dti-1319	37	20	more	more	ADV
dti-1319	37	21	recently	recently	ADV
dti-1319	37	22	,	,	PUNCT
dti-1319	37	23	also	also	ADV
dti-1319	37	24	vertebrates	vertebrate	VERB
dti-1319	37	25	such	such	ADJ
dti-1319	37	26	as	as	ADP
dti-1319	37	27	xenopus	xenopus	PROPN
dti-1319	37	28	and	and	CCONJ
dti-1319	37	29	mice	mouse	NOUN
dti-1319	37	30	(	(	PUNCT
dti-1319	37	31	nakano	nakano	NOUN
dti-1319	37	32	et	et	PROPN
dti-1319	37	33	al	al	PROPN
dti-1319	37	34	.	.	PROPN
dti-1319	37	35	2000	2000	NUM
dti-1319	37	36	;	;	PUNCT
dti-1319	37	37	wianny	wianny	NOUN
dti-1319	37	38	and	and	CCONJ
dti-1319	37	39	zernicka	zernicka	PROPN
dti-1319	37	40	-	-	PUNCT
dti-1319	37	41	goetz	goetz	PROPN
dti-1319	37	42	,	,	PUNCT
dti-1319	37	43	2000	2000	NUM
dti-1319	37	44	)	)	PUNCT
dti-1319	37	45	.	.	PUNCT
dti-1319	38	1	for	for	ADP
dti-1319	38	2	induction	induction	NOUN
dti-1319	38	3	of	of	ADP
dti-1319	38	4	rnai	rnai	PROPN
dti-1319	38	5	,	,	PUNCT
dti-1319	38	6	small	small	ADJ
dti-1319	38	7	double	double	ADJ
dti-1319	38	8	stranded	strand	VERB
dti-1319	38	9	rnas	rna	NOUN
dti-1319	38	10	(	(	PUNCT
dti-1319	38	11	termed	term	VERB
dti-1319	38	12	small	small	ADJ
dti-1319	38	13	interfering	interfere	VERB
dti-1319	38	14	rnas	rna	NOUN
dti-1319	38	15	–	–	PUNCT
dti-1319	38	16	sirnas	sirna	NOUN
dti-1319	38	17	)	)	PUNCT
dti-1319	38	18	are	be	AUX
dti-1319	38	19	produced	produce	VERB
dti-1319	38	20	by	by	ADP
dti-1319	38	21	the	the	DET
dti-1319	38	22	cleavage	cleavage	NOUN
dti-1319	38	23	of	of	ADP
dti-1319	38	24	long	long	ADJ
dti-1319	38	25	dsrnas	dsrna	NOUN
dti-1319	38	26	(	(	PUNCT
dti-1319	38	27	tuschl	tuschl	NOUN
dti-1319	38	28	et	et	PROPN
dti-1319	38	29	al	al	PROPN
dti-1319	38	30	.	.	PROPN
dti-1319	38	31	1999	1999	NUM
dti-1319	38	32	;	;	PUNCT
dti-1319	39	1	zamore	zamore	X
dti-1319	39	2	et	et	PROPN
dti-1319	39	3	al	al	PROPN
dti-1319	39	4	.	.	PROPN
dti-1319	39	5	2000	2000	NUM
dti-1319	39	6	;	;	PUNCT
dti-1319	39	7	hamilton	hamilton	PROPN
dti-1319	39	8	and	and	CCONJ
dti-1319	39	9	baulcombe	baulcombe	PROPN
dti-1319	39	10	,	,	PUNCT
dti-1319	39	11	1999	1999	NUM
dti-1319	39	12	;	;	PUNCT
dti-1319	39	13	hammond	hammond	PROPN
dti-1319	39	14	et	et	PROPN
dti-1319	39	15	al	al	PROPN
dti-1319	39	16	.	.	PROPN
dti-1319	39	17	2000	2000	NUM
dti-1319	39	18	)	)	PUNCT
dti-1319	39	19	.	.	PUNCT
dti-1319	40	1	the	the	DET
dti-1319	40	2	cytoplasmic	cytoplasmic	ADJ
dti-1319	40	3	,	,	PUNCT
dti-1319	40	4	highly	highly	ADV
dti-1319	40	5	conserved	conserved	ADJ
dti-1319	40	6	dicer	dicer	NOUN
dti-1319	40	7	protein	protein	NOUN
dti-1319	40	8	,	,	PUNCT
dti-1319	40	9	member	member	NOUN
dti-1319	40	10	of	of	ADP
dti-1319	40	11	the	the	DET
dti-1319	40	12	family	family	NOUN
dti-1319	40	13	of	of	ADP
dti-1319	40	14	rnase	rnase	PROPN
dti-1319	40	15	iii	iii	PROPN
dti-1319	40	16	–	–	PUNCT
dti-1319	40	17	like	like	ADJ
dti-1319	40	18	enzymes	enzyme	NOUN
dti-1319	40	19	,	,	PUNCT
dti-1319	40	20	forms	form	VERB
dti-1319	40	21	a	a	DET
dti-1319	40	22	characteristical	characteristical	ADJ
dti-1319	40	23	21–23	21–23	ADJ
dti-1319	40	24	-	-	PUNCT
dti-1319	40	25	nucleotide	nucleotide	ADJ
dti-1319	40	26	long	long	ADJ
dti-1319	40	27	dsrna	dsrna	NOUN
dti-1319	40	28	duplex	duplex	NOUN
dti-1319	40	29	with	with	ADP
dti-1319	40	30	symmetric	symmetric	PROPN
dti-1319	40	31	twoto	twoto	PROPN
dti-1319	40	32	threenucleotide	threenucleotide	NOUN
dti-1319	40	33	3	3	NUM
dti-1319	40	34	'	'	PART
dti-1319	40	35	overhangs	overhang	NOUN
dti-1319	40	36	(	(	PUNCT
dti-1319	40	37	bernstein	bernstein	PROPN
dti-1319	40	38	et	et	PROPN
dti-1319	40	39	al	al	PROPN
dti-1319	40	40	.	.	PROPN
dti-1319	40	41	2001	2001	NUM
dti-1319	40	42	;	;	PUNCT
dti-1319	40	43	elbashir	elbashir	VERB
dti-1319	40	44	et	et	PROPN
dti-1319	40	45	al	al	PROPN
dti-1319	40	46	.	.	PROPN
dti-1319	40	47	2001a	2001a	NUM
dti-1319	40	48	)	)	PUNCT
dti-1319	40	49	.	.	PUNCT
dti-1319	41	1	the	the	DET
dti-1319	41	2	duplex	duplex	NOUN
dti-1319	41	3	small	small	ADV
dti-1319	41	4	-	-	PUNCT
dti-1319	41	5	interfering	interfere	VERB
dti-1319	41	6	(	(	PUNCT
dti-1319	41	7	si)-rnas	si)-rnas	NOUN
dti-1319	41	8	(	(	PUNCT
dti-1319	41	9	products	product	NOUN
dti-1319	41	10	of	of	ADP
dti-1319	41	11	the	the	DET
dti-1319	41	12	long	long	ADJ
dti-1319	41	13	dsrna	dsrna	PROPN
dti-1319	41	14	cleavage	cleavage	NOUN
dti-1319	41	15	)	)	PUNCT
dti-1319	41	16	are	be	AUX
dti-1319	41	17	integrated	integrate	VERB
dti-1319	41	18	into	into	ADP
dti-1319	41	19	the	the	DET
dti-1319	41	20	risc	risc	PROPN
dti-1319	41	21	complex	complex	NOUN
dti-1319	41	22	(	(	PUNCT
dti-1319	41	23	rnainduced	rnainduced	ADJ
dti-1319	41	24	silencing	silence	VERB
dti-1319	41	25	complex	complex	NOUN
dti-1319	41	26	)	)	PUNCT
dti-1319	41	27	.	.	PUNCT
dti-1319	42	1	the	the	DET
dti-1319	42	2	complex	complex	NOUN
dti-1319	42	3	becomes	becomes	AUX
dti-1319	42	4	activated	activate	VERB
dti-1319	42	5	by	by	ADP
dti-1319	42	6	the	the	DET
dti-1319	42	7	unwinding	unwinding	NOUN
dti-1319	42	8	of	of	ADP
dti-1319	42	9	the	the	DET
dti-1319	42	10	duplex	duplex	NOUN
dti-1319	42	11	upon	upon	SCONJ
dti-1319	42	12	the	the	DET
dti-1319	42	13	loss	loss	NOUN
dti-1319	42	14	of	of	ADP
dti-1319	42	15	one	one	NUM
dti-1319	42	16	strand	strand	NOUN
dti-1319	42	17	of	of	ADP
dti-1319	42	18	the	the	DET
dti-1319	42	19	si	si	ADJ
dti-1319	42	20	-	-	ADJ
dti-1319	42	21	rna	rna	NOUN
dti-1319	42	22	duplex	duplex	NOUN
dti-1319	42	23	by	by	ADP
dti-1319	42	24	an	an	DET
dti-1319	42	25	rna	rna	NOUN
dti-1319	42	26	helicase	helicase	NOUN
dti-1319	42	27	activity	activity	NOUN
dti-1319	42	28	.	.	PUNCT
dti-1319	43	1	depending	depend	VERB
dti-1319	43	2	on	on	ADP
dti-1319	43	3	several	several	ADJ
dti-1319	43	4	target	target	NOUN
dti-1319	43	5	and	and	CCONJ
dti-1319	43	6	si	si	ADJ
dti-1319	43	7	-	-	ADJ
dti-1319	43	8	rna	rna	NOUN
dti-1319	43	9	properties	property	NOUN
dti-1319	43	10	that	that	PRON
dti-1319	43	11	are	be	AUX
dti-1319	43	12	not	not	PART
dti-1319	43	13	entirely	entirely	ADV
dti-1319	43	14	understood	understand	VERB
dti-1319	43	15	,	,	PUNCT
dti-1319	43	16	risc	risc	PROPN
dti-1319	43	17	can	can	AUX
dti-1319	43	18	either	either	CCONJ
dti-1319	43	19	specifi	specifi	VERB
dti-1319	43	20	cally	cally	ADV
dti-1319	43	21	cleave	cleave	VERB
dti-1319	43	22	and	and	CCONJ
dti-1319	43	23	degrade	degrade	VERB
dti-1319	43	24	target	target	NOUN
dti-1319	43	25	mrna	mrna	NOUN
dti-1319	43	26	(	(	PUNCT
dti-1319	43	27	yekta	yekta	NOUN
dti-1319	43	28	et	et	PROPN
dti-1319	43	29	al	al	PROPN
dti-1319	43	30	.	.	PROPN
dti-1319	43	31	2004	2004	NUM
dti-1319	43	32	;	;	PUNCT
dti-1319	43	33	meister	meister	PROPN
dti-1319	43	34	et	et	PROPN
dti-1319	43	35	al	al	PROPN
dti-1319	43	36	.	.	PROPN
dti-1319	43	37	2004	2004	NUM
dti-1319	43	38	;	;	PUNCT
dti-1319	43	39	zamore	zamore	PART
dti-1319	43	40	et	et	PROPN
dti-1319	43	41	al	al	PROPN
dti-1319	43	42	.	.	PROPN
dti-1319	43	43	2000	2000	NUM
dti-1319	43	44	;	;	PUNCT
dti-1319	43	45	bagga	bagga	PROPN
dti-1319	43	46	et	et	PROPN
dti-1319	43	47	al	al	PROPN
dti-1319	43	48	.	.	PROPN
dti-1319	43	49	2005	2005	NUM
dti-1319	43	50	;	;	PUNCT
dti-1319	43	51	giraldez	giraldez	NOUN
dti-1319	43	52	et	et	PROPN
dti-1319	43	53	al	al	PROPN
dti-1319	43	54	.	.	PROPN
dti-1319	43	55	2005	2005	NUM
dti-1319	43	56	;	;	PUNCT
dti-1319	43	57	wu	wu	PROPN
dti-1319	43	58	et	et	PROPN
dti-1319	43	59	al	al	PROPN
dti-1319	43	60	.	.	PROPN
dti-1319	43	61	2006	2006	NUM
dti-1319	43	62	)	)	PUNCT
dti-1319	43	63	or	or	CCONJ
dti-1319	43	64	inhibit	inhibit	VERB
dti-1319	43	65	its	its	PRON
dti-1319	43	66	translation	translation	NOUN
dti-1319	43	67	without	without	ADP
dti-1319	43	68	initiating	initiate	VERB
dti-1319	43	69	its	its	PRON
dti-1319	43	70	sequence	sequence	NOUN
dti-1319	43	71	-	-	PUNCT
dti-1319	43	72	specifi	specifi	PROPN
dti-1319	43	73	c	c	PROPN
dti-1319	43	74	mrna	mrna	PROPN
dti-1319	43	75	degradation	degradation	NOUN
dti-1319	43	76	process	process	NOUN
dti-1319	43	77	(	(	PUNCT
dti-1319	43	78	olsen	olsen	NOUN
dti-1319	43	79	and	and	CCONJ
dti-1319	43	80	ambros	ambros	PROPN
dti-1319	43	81	,	,	PUNCT
dti-1319	43	82	1999	1999	NUM
dti-1319	43	83	;	;	PUNCT
dti-1319	43	84	reinhart	reinhart	PROPN
dti-1319	43	85	et	et	PROPN
dti-1319	43	86	al	al	PROPN
dti-1319	43	87	.	.	PROPN
dti-1319	43	88	2000	2000	NUM
dti-1319	43	89	;	;	PUNCT
dti-1319	43	90	wightman	wightman	NOUN
dti-1319	43	91	et	et	PROPN
dti-1319	43	92	al	al	PROPN
dti-1319	43	93	.	.	PROPN
dti-1319	43	94	1993	1993	NUM
dti-1319	43	95	)	)	PUNCT
dti-1319	43	96	.	.	PUNCT
dti-1319	44	1	the	the	DET
dti-1319	44	2	target	target	NOUN
dti-1319	44	3	mrna	mrna	NOUN
dti-1319	44	4	is	be	AUX
dti-1319	44	5	cleaved	cleave	VERB
dti-1319	44	6	by	by	ADP
dti-1319	44	7	the	the	DET
dti-1319	44	8	risc	risc	PROPN
dti-1319	44	9	complex	complex	NOUN
dti-1319	44	10	at	at	ADP
dti-1319	44	11	the	the	DET
dti-1319	44	12	middle	middle	NOUN
dti-1319	44	13	of	of	ADP
dti-1319	44	14	the	the	DET
dti-1319	44	15	complementary	complementary	ADJ
dti-1319	44	16	region	region	NOUN
dti-1319	44	17	,	,	PUNCT
dti-1319	44	18	ten	ten	NUM
dti-1319	44	19	nucleotides	nucleotide	NOUN
dti-1319	44	20	upstream	upstream	ADJ
dti-1319	44	21	of	of	ADP
dti-1319	44	22	the	the	DET
dti-1319	44	23	nucleotide	nucleotide	NOUN
dti-1319	44	24	paired	pair	VERB
dti-1319	44	25	with	with	ADP
dti-1319	44	26	the	the	DET
dti-1319	44	27	5	5	NUM
dti-1319	44	28	'	'	PART
dti-1319	44	29	end	end	NOUN
dti-1319	44	30	of	of	ADP
dti-1319	44	31	the	the	DET
dti-1319	44	32	guide	guide	NOUN
dti-1319	44	33	sirna	sirna	PROPN
dti-1319	44	34	(	(	PUNCT
dti-1319	44	35	elbashir	elbashir	VERB
dti-1319	44	36	et	et	PROPN
dti-1319	44	37	al	al	PROPN
dti-1319	44	38	.	.	PROPN
dti-1319	44	39	2001b	2001b	NUM
dti-1319	44	40	)	)	PUNCT
dti-1319	44	41	.	.	PUNCT
dti-1319	45	1	the	the	DET
dti-1319	45	2	cleavage	cleavage	NOUN
dti-1319	45	3	reaction	reaction	NOUN
dti-1319	45	4	guided	guide	VERB
dti-1319	45	5	by	by	ADP
dti-1319	45	6	risc	risc	PROPN
dti-1319	45	7	does	do	AUX
dti-1319	45	8	not	not	PART
dti-1319	45	9	require	require	VERB
dti-1319	45	10	atp	atp	PROPN
dti-1319	45	11	(	(	PUNCT
dti-1319	45	12	nykänen	nykänen	NOUN
dti-1319	45	13	et	et	PROPN
dti-1319	45	14	al	al	PROPN
dti-1319	45	15	.	.	PROPN
dti-1319	45	16	2001	2001	NUM
dti-1319	45	17	;	;	PUNCT
dti-1319	45	18	hutvágner	hutvágner	PROPN
dti-1319	45	19	and	and	CCONJ
dti-1319	45	20	zamore	zamore	ADJ
dti-1319	45	21	,	,	PUNCT
dti-1319	45	22	2002	2002	NUM
dti-1319	45	23	)	)	PUNCT
dti-1319	45	24	.	.	PUNCT
dti-1319	46	1	however	however	ADV
dti-1319	46	2	,	,	PUNCT
dti-1319	46	3	multiple	multiple	ADJ
dti-1319	46	4	rounds	round	NOUN
dti-1319	46	5	of	of	ADP
dti-1319	46	6	mrna	mrna	PROPN
dti-1319	46	7	cleavage	cleavage	NOUN
dti-1319	46	8	,	,	PUNCT
dti-1319	46	9	which	which	PRON
dti-1319	46	10	requires	require	VERB
dti-1319	46	11	the	the	DET
dti-1319	46	12	release	release	NOUN
dti-1319	46	13	of	of	ADP
dti-1319	46	14	cleaved	cleaved	ADJ
dti-1319	46	15	mrna	mrna	PROPN
dti-1319	46	16	products	product	NOUN
dti-1319	46	17	,	,	PUNCT
dti-1319	46	18	are	be	AUX
dti-1319	46	19	more	more	ADJ
dti-1319	46	20	effi	effi	PROPN
dti-1319	46	21	cient	cient	NOUN
dti-1319	46	22	in	in	ADP
dti-1319	46	23	the	the	DET
dti-1319	46	24	presence	presence	NOUN
dti-1319	46	25	of	of	ADP
dti-1319	46	26	atp	atp	PROPN
dti-1319	46	27	(	(	PUNCT
dti-1319	46	28	hutvágner	hutvágner	PROPN
dti-1319	46	29	and	and	CCONJ
dti-1319	46	30	zamore	zamore	ADJ
dti-1319	46	31	,	,	PUNCT
dti-1319	46	32	2002	2002	NUM
dti-1319	46	33	)	)	PUNCT
dti-1319	46	34	.	.	PUNCT
dti-1319	47	1	when	when	SCONJ
dti-1319	47	2	the	the	DET
dti-1319	47	3	dsrna	dsrna	NOUN
dti-1319	47	4	is	be	AUX
dti-1319	47	5	of	of	ADP
dti-1319	47	6	endogenous	endogenous	ADJ
dti-1319	47	7	origin	origin	NOUN
dti-1319	47	8	,	,	PUNCT
dti-1319	47	9	the	the	DET
dti-1319	47	10	dicer	dicer	NOUN
dti-1319	47	11	cleavage	cleavage	NOUN
dti-1319	47	12	products	product	NOUN
dti-1319	47	13	are	be	AUX
dti-1319	47	14	named	name	VERB
dti-1319	47	15	micro	micro	ADJ
dti-1319	47	16	rna	rna	PROPN
dti-1319	47	17	(	(	PUNCT
dti-1319	47	18	mirna	mirna	PROPN
dti-1319	47	19	)	)	PUNCT
dti-1319	47	20	.	.	PUNCT
dti-1319	48	1	the	the	DET
dti-1319	48	2	mirna	mirna	NOUN
dti-1319	48	3	-	-	PUNCT
dti-1319	48	4	guided	guide	VERB
dti-1319	48	5	mechanism	mechanism	NOUN
dti-1319	48	6	of	of	ADP
dti-1319	48	7	translational	translational	ADJ
dti-1319	48	8	regulation	regulation	NOUN
dti-1319	48	9	is	be	AUX
dti-1319	48	10	not	not	PART
dti-1319	48	11	as	as	ADV
dti-1319	48	12	well	well	ADV
dti-1319	48	13	understood	understand	VERB
dti-1319	48	14	.	.	PUNCT
dti-1319	49	1	studies	study	NOUN
dti-1319	49	2	of	of	ADP
dti-1319	49	3	mutant	mutant	NOUN
dti-1319	49	4	or	or	CCONJ
dti-1319	49	5	transgenic	transgenic	NOUN
dti-1319	49	6	c.	c.	NOUN
dti-1319	49	7	elegans	elegan	NOUN
dti-1319	49	8	,	,	PUNCT
dti-1319	49	9	showed	show	VERB
dti-1319	49	10	that	that	SCONJ
dti-1319	49	11	mirnas	mirna	NOUN
dti-1319	49	12	inhibited	inhibited	ADJ
dti-1319	49	13	target	target	NOUN
dti-1319	49	14	-	-	PUNCT
dti-1319	49	15	protein	protein	NOUN
dti-1319	49	16	synthesis	synthesis	NOUN
dti-1319	49	17	without	without	ADP
dti-1319	49	18	affecting	affect	VERB
dti-1319	49	19	mrna	mrna	PROPN
dti-1319	49	20	levels	level	NOUN
dti-1319	49	21	(	(	PUNCT
dti-1319	49	22	bartel	bartel	NOUN
dti-1319	49	23	,	,	PUNCT
dti-1319	49	24	2004	2004	NUM
dti-1319	49	25	)	)	PUNCT
dti-1319	49	26	.	.	PUNCT
dti-1319	50	1	the	the	DET
dti-1319	50	2	target	target	PROPN
dti-1319	50	3	mrna	mrna	PROPN
dti-1319	50	4	contains	contain	VERB
dti-1319	50	5	three	three	NUM
dti-1319	50	6	-	-	PUNCT
dti-1319	50	7	prime	prime	ADJ
dti-1319	50	8	untranslated	untranslated	ADJ
dti-1319	50	9	regions	region	NOUN
dti-1319	50	10	with	with	ADP
dti-1319	50	11	several	several	ADJ
dti-1319	50	12	binding	bind	VERB
dti-1319	50	13	sites	site	NOUN
dti-1319	50	14	for	for	ADP
dti-1319	50	15	the	the	DET
dti-1319	50	16	mirna	mirna	NOUN
dti-1319	50	17	,	,	PUNCT
dti-1319	50	18	and	and	CCONJ
dti-1319	50	19	both	both	CCONJ
dti-1319	50	20	the	the	DET
dti-1319	50	21	target	target	NOUN
dti-1319	50	22	and	and	CCONJ
dti-1319	50	23	the	the	DET
dti-1319	50	24	mirna	mirna	NOUN
dti-1319	50	25	were	be	AUX
dti-1319	50	26	found	find	VERB
dti-1319	50	27	to	to	PART
dti-1319	50	28	be	be	AUX
dti-1319	50	29	associated	associate	VERB
dti-1319	50	30	with	with	ADP
dti-1319	50	31	polyribosomes	polyribosome	NOUN
dti-1319	50	32	.	.	PUNCT
dti-1319	51	1	this	this	PRON
dti-1319	51	2	suggested	suggest	VERB
dti-1319	51	3	that	that	SCONJ
dti-1319	51	4	mirnas	mirna	NOUN
dti-1319	51	5	block	block	NOUN
dti-1319	51	6	translation	translation	NOUN
dti-1319	51	7	elongation	elongation	NOUN
dti-1319	51	8	or	or	CCONJ
dti-1319	51	9	termination	termination	NOUN
dti-1319	51	10	rather	rather	ADV
dti-1319	51	11	than	than	ADP
dti-1319	51	12	translational	translational	ADJ
dti-1319	51	13	initiation	initiation	NOUN
dti-1319	51	14	(	(	PUNCT
dti-1319	51	15	olsen	olsen	NOUN
dti-1319	51	16	and	and	CCONJ
dti-1319	51	17	ambros	ambros	PROPN
dti-1319	51	18	,	,	PUNCT
dti-1319	51	19	1999	1999	NUM
dti-1319	51	20	;	;	PUNCT
dti-1319	51	21	seggerson	seggerson	PROPN
dti-1319	51	22	et	et	PROPN
dti-1319	51	23	al	al	PROPN
dti-1319	51	24	.	.	PROPN
dti-1319	51	25	2002	2002	NUM
dti-1319	51	26	)	)	PUNCT
dti-1319	51	27	.	.	PUNCT
dti-1319	52	1	by	by	ADP
dti-1319	52	2	using	use	VERB
dti-1319	52	3	protein	protein	NOUN
dti-1319	52	4	mutants	mutant	NOUN
dti-1319	52	5	various	various	ADJ
dti-1319	52	6	genes	gene	NOUN
dti-1319	52	7	involved	involve	VERB
dti-1319	52	8	in	in	ADP
dti-1319	52	9	the	the	DET
dti-1319	52	10	rnai	rnai	NOUN
dti-1319	52	11	process	process	NOUN
dti-1319	52	12	were	be	AUX
dti-1319	52	13	identifi	identifi	PROPN
dti-1319	52	14	ed	ed	NOUN
dti-1319	52	15	,	,	PUNCT
dti-1319	52	16	including	include	VERB
dti-1319	52	17	some	some	DET
dti-1319	52	18	highly	highly	ADV
dti-1319	52	19	homologous	homologous	ADJ
dti-1319	52	20	helicases	helicase	NOUN
dti-1319	52	21	and	and	CCONJ
dti-1319	52	22	other	other	ADJ
dti-1319	52	23	enzymes	enzyme	NOUN
dti-1319	52	24	involved	involve	VERB
dti-1319	52	25	in	in	ADP
dti-1319	52	26	the	the	DET
dti-1319	52	27	transposition	transposition	NOUN
dti-1319	52	28	of	of	ADP
dti-1319	52	29	mobile	mobile	ADJ
dti-1319	52	30	elements	element	NOUN
dti-1319	52	31	,	,	PUNCT
dti-1319	52	32	such	such	ADJ
dti-1319	52	33	as	as	ADP
dti-1319	52	34	rnase	rnase	PROPN
dti-1319	52	35	d	d	PROPN
dti-1319	52	36	(	(	PUNCT
dti-1319	52	37	bertrand	bertrand	PROPN
dti-1319	52	38	et	et	PROPN
dti-1319	52	39	al	al	PROPN
dti-1319	52	40	.	.	PROPN
dti-1319	52	41	2002	2002	NUM
dti-1319	52	42	;	;	PUNCT
dti-1319	52	43	mcmanus	mcmanus	PROPN
dti-1319	52	44	and	and	CCONJ
dti-1319	52	45	sharp	sharp	ADJ
dti-1319	52	46	,	,	PUNCT
dti-1319	52	47	2002	2002	NUM
dti-1319	52	48	;	;	PUNCT
dti-1319	52	49	scherr	scherr	PROPN
dti-1319	52	50	et	et	PROPN
dti-1319	52	51	al	al	PROPN
dti-1319	52	52	.	.	PROPN
dti-1319	52	53	2003	2003	NUM
dti-1319	52	54	)	)	PUNCT
dti-1319	52	55	.	.	PUNCT
dti-1319	53	1	results	result	NOUN
dti-1319	53	2	like	like	SCONJ
dti-1319	53	3	these	these	PRON
dti-1319	53	4	corroborate	corroborate	VERB
dti-1319	53	5	the	the	DET
dti-1319	53	6	currently	currently	ADV
dti-1319	53	7	accepted	accept	VERB
dti-1319	53	8	hypothesis	hypothesis	NOUN
dti-1319	53	9	that	that	SCONJ
dti-1319	53	10	the	the	DET
dti-1319	53	11	response	response	NOUN
dti-1319	53	12	to	to	ADP
dti-1319	53	13	dsrnas	dsrnas	PROPN
dti-1319	53	14	plays	play	VERB
dti-1319	53	15	a	a	DET
dti-1319	53	16	defensive	defensive	ADJ
dti-1319	53	17	physiologic	physiologic	ADJ
dti-1319	53	18	role	role	NOUN
dti-1319	53	19	against	against	ADP
dti-1319	53	20	deleterious	deleterious	ADJ
dti-1319	53	21	rnas	rna	NOUN
dti-1319	53	22	such	such	ADJ
dti-1319	53	23	as	as	ADP
dti-1319	53	24	virus	virus	NOUN
dti-1319	53	25	transcripts	transcript	NOUN
dti-1319	53	26	.	.	PUNCT
dti-1319	54	1	therefore	therefore	ADV
dti-1319	54	2	mirnas	mirna	NOUN
dti-1319	54	3	are	be	AUX
dti-1319	54	4	essential	essential	ADJ
dti-1319	54	5	for	for	ADP
dti-1319	54	6	the	the	DET
dti-1319	54	7	maintenance	maintenance	NOUN
dti-1319	54	8	of	of	ADP
dti-1319	54	9	genome	genome	NOUN
dti-1319	54	10	integrity	integrity	NOUN
dti-1319	54	11	in	in	ADP
dti-1319	54	12	a	a	DET
dti-1319	54	13	large	large	ADJ
dti-1319	54	14	range	range	NOUN
dti-1319	54	15	of	of	ADP
dti-1319	54	16	biological	biological	ADJ
dti-1319	54	17	185	185	NUM
dti-1319	54	18	delivery	delivery	NOUN
dti-1319	54	19	systems	system	NOUN
dti-1319	54	20	of	of	ADP
dti-1319	54	21	nucleic	nucleic	ADJ
dti-1319	54	22	acids	acid	NOUN
dti-1319	54	23	drugs	drug	NOUN
dti-1319	54	24	drug	drug	NOUN
dti-1319	54	25	target	target	NOUN
dti-1319	54	26	insights	insight	NOUN
dti-1319	54	27	2007:2	2007:2	NUM
dti-1319	54	28	figure	figure	NOUN
dti-1319	54	29	1	1	NUM
dti-1319	54	30	.	.	PUNCT
dti-1319	55	1	nucleic	nucleic	ADJ
dti-1319	55	2	-	-	PUNCT
dti-1319	55	3	acid	acid	ADJ
dti-1319	55	4	based	base	VERB
dti-1319	55	5	therapies	therapy	NOUN
dti-1319	55	6	.	.	PUNCT
dti-1319	56	1	(	(	PUNCT
dti-1319	56	2	a	a	X
dti-1319	56	3	)	)	PUNCT
dti-1319	56	4	actions	action	NOUN
dti-1319	56	5	of	of	ADP
dti-1319	56	6	antisense	antisense	NOUN
dti-1319	56	7	oligonucleotides	oligonucleotide	NOUN
dti-1319	56	8	,	,	PUNCT
dti-1319	56	9	small	small	ADJ
dti-1319	56	10	interfering	interfering	NOUN
dti-1319	56	11	rnas	rna	NOUN
dti-1319	56	12	,	,	PUNCT
dti-1319	56	13	aptamers	aptamer	NOUN
dti-1319	56	14	and	and	CCONJ
dti-1319	56	15	intramers	intramer	NOUN
dti-1319	56	16	(	(	PUNCT
dti-1319	56	17	intracellularly	intracellularly	ADV
dti-1319	56	18	acting	act	VERB
dti-1319	56	19	aptamers	aptamer	NOUN
dti-1319	56	20	)	)	PUNCT
dti-1319	56	21	on	on	ADP
dti-1319	56	22	target	target	NOUN
dti-1319	56	23	cells	cell	NOUN
dti-1319	56	24	.	.	PUNCT
dti-1319	57	1	the	the	DET
dti-1319	57	2	antisense	antisense	NOUN
dti-1319	57	3	technology	technology	NOUN
dti-1319	57	4	is	be	AUX
dti-1319	57	5	based	base	VERB
dti-1319	57	6	on	on	ADP
dti-1319	57	7	the	the	DET
dti-1319	57	8	introduction	introduction	NOUN
dti-1319	57	9	of	of	ADP
dti-1319	57	10	a	a	DET
dti-1319	57	11	complementary	complementary	ADJ
dti-1319	57	12	oligonucleotide	oligonucleotide	NOUN
dti-1319	57	13	sequence	sequence	NOUN
dti-1319	57	14	to	to	ADP
dti-1319	57	15	the	the	DET
dti-1319	57	16	target	target	NOUN
dti-1319	57	17	mrna	mrna	PROPN
dti-1319	57	18	resulting	result	VERB
dti-1319	57	19	in	in	ADP
dti-1319	57	20	rnase	rnase	PROPN
dti-1319	57	21	h	h	NOUN
dti-1319	57	22	activation	activation	NOUN
dti-1319	57	23	and	and	CCONJ
dti-1319	57	24	target	target	VERB
dti-1319	57	25	rna	rna	NOUN
dti-1319	57	26	degradation	degradation	NOUN
dti-1319	57	27	.	.	PUNCT
dti-1319	58	1	for	for	ADP
dti-1319	58	2	rna	rna	NOUN
dti-1319	58	3	interference	interference	NOUN
dti-1319	58	4	process	process	NOUN
dti-1319	58	5	21–23	21–23	PROPN
dti-1319	58	6	nucleotide	nucleotide	NOUN
dti-1319	58	7	-	-	PUNCT
dti-1319	58	8	long	long	ADJ
dti-1319	58	9	sirnas	sirna	NOUN
dti-1319	58	10	induced	induce	VERB
dti-1319	58	11	into	into	ADP
dti-1319	58	12	the	the	DET
dti-1319	58	13	cell	cell	NOUN
dti-1319	58	14	activate	activate	VERB
dti-1319	58	15	the	the	DET
dti-1319	58	16	risc	risc	PROPN
dti-1319	58	17	complex	complex	NOUN
dti-1319	58	18	leading	lead	VERB
dti-1319	58	19	to	to	ADP
dti-1319	58	20	degradation	degradation	NOUN
dti-1319	58	21	of	of	ADP
dti-1319	58	22	target	target	NOUN
dti-1319	58	23	mrna	mrna	PROPN
dti-1319	58	24	.	.	PUNCT
dti-1319	59	1	rna	rna	PROPN
dti-1319	59	2	or	or	CCONJ
dti-1319	59	3	dna	dna	PROPN
dti-1319	59	4	aptamers	aptamer	NOUN
dti-1319	59	5	target	target	VERB
dti-1319	59	6	and	and	CCONJ
dti-1319	59	7	inhibit	inhibit	VERB
dti-1319	59	8	the	the	DET
dti-1319	59	9	products	product	NOUN
dti-1319	59	10	of	of	ADP
dti-1319	59	11	gene	gene	NOUN
dti-1319	59	12	expression	expression	NOUN
dti-1319	59	13	such	such	ADJ
dti-1319	59	14	as	as	ADP
dti-1319	59	15	intracellular	intracellular	ADJ
dti-1319	59	16	or	or	CCONJ
dti-1319	59	17	extracellular	extracellular	ADJ
dti-1319	59	18	protein	protein	NOUN
dti-1319	59	19	.	.	PUNCT
dti-1319	60	1	(	(	PUNCT
dti-1319	60	2	b	b	X
dti-1319	60	3	)	)	PUNCT
dti-1319	60	4	conventional	conventional	ADJ
dti-1319	60	5	delivery	delivery	NOUN
dti-1319	60	6	of	of	ADP
dti-1319	60	7	sirna	sirna	PROPN
dti-1319	60	8	to	to	PART
dti-1319	60	9	target	target	VERB
dti-1319	60	10	cells	cell	NOUN
dti-1319	60	11	by	by	ADP
dti-1319	60	12	transfection	transfection	NOUN
dti-1319	60	13	.	.	PUNCT
dti-1319	61	1	therapeutic	therapeutic	ADJ
dti-1319	61	2	applications	application	NOUN
dti-1319	61	3	are	be	AUX
dti-1319	61	4	hindered	hinder	VERB
dti-1319	61	5	due	due	ADP
dti-1319	61	6	to	to	ADP
dti-1319	61	7	poor	poor	ADJ
dti-1319	61	8	cellular	cellular	ADJ
dti-1319	61	9	uptake	uptake	NOUN
dti-1319	61	10	and	and	CCONJ
dti-1319	61	11	absence	absence	NOUN
dti-1319	61	12	of	of	ADP
dti-1319	61	13	a	a	DET
dti-1319	61	14	mechanism	mechanism	NOUN
dti-1319	61	15	to	to	PART
dti-1319	61	16	deliver	deliver	VERB
dti-1319	61	17	sirnas	sirnas	PROPN
dti-1319	61	18	specifi	specifi	PROPN
dti-1319	61	19	cally	cally	ADV
dti-1319	61	20	to	to	PART
dti-1319	61	21	target	target	VERB
dti-1319	61	22	cells	cell	NOUN
dti-1319	61	23	.	.	PUNCT
dti-1319	62	1	(	(	PUNCT
dti-1319	62	2	c	c	X
dti-1319	62	3	)	)	PUNCT
dti-1319	62	4	aptamer	aptamer	NOUN
dti-1319	62	5	-	-	PUNCT
dti-1319	62	6	directed	direct	VERB
dti-1319	62	7	sirna	sirna	PROPN
dti-1319	62	8	delivery	delivery	NOUN
dti-1319	62	9	to	to	PART
dti-1319	62	10	target	target	VERB
dti-1319	62	11	cells	cell	NOUN
dti-1319	62	12	.	.	PUNCT
dti-1319	63	1	the	the	PRON
dti-1319	63	2	si	si	PROPN
dti-1319	63	3	-	-	PUNCT
dti-1319	63	4	rna	rna	NOUN
dti-1319	63	5	is	be	AUX
dti-1319	63	6	coupled	couple	VERB
dti-1319	63	7	to	to	ADP
dti-1319	63	8	an	an	DET
dti-1319	63	9	aptamer	aptamer	NOUN
dti-1319	63	10	which	which	PRON
dti-1319	63	11	specifically	specifically	ADV
dti-1319	63	12	binds	bind	VERB
dti-1319	63	13	a	a	DET
dti-1319	63	14	surface	surface	NOUN
dti-1319	63	15	epitope	epitope	NOUN
dti-1319	63	16	on	on	ADP
dti-1319	63	17	target	target	NOUN
dti-1319	63	18	cells	cell	NOUN
dti-1319	63	19	(	(	PUNCT
dti-1319	63	20	i.e.	i.e.	X
dti-1319	63	21	prostate	prostate	NOUN
dti-1319	63	22	-	-	PUNCT
dti-1319	63	23	specifi	specifi	PROPN
dti-1319	63	24	c	c	PROPN
dti-1319	63	25	membrane	membrane	NOUN
dti-1319	63	26	antigen	antigen	ADV
dti-1319	63	27	)	)	PUNCT
dti-1319	63	28	,	,	PUNCT
dti-1319	63	29	thereby	thereby	ADV
dti-1319	63	30	possibiliting	possibilite	VERB
dti-1319	63	31	the	the	DET
dti-1319	63	32	specific	specific	ADJ
dti-1319	63	33	down	down	ADJ
dti-1319	63	34	-	-	PUNCT
dti-1319	63	35	regulation	regulation	NOUN
dti-1319	63	36	of	of	ADP
dti-1319	63	37	gene	gene	NOUN
dti-1319	63	38	expression	expression	NOUN
dti-1319	63	39	in	in	ADP
dti-1319	63	40	cancer	cancer	NOUN
dti-1319	63	41	cells	cell	NOUN
dti-1319	63	42	.	.	PUNCT
dti-1319	64	1	following	follow	VERB
dti-1319	64	2	binding	bind	VERB
dti-1319	64	3	of	of	ADP
dti-1319	64	4	the	the	DET
dti-1319	64	5	sirna	sirna	PROPN
dti-1319	64	6	-	-	PUNCT
dti-1319	64	7	aptamer	aptamer	PROPN
dti-1319	64	8	chimera	chimera	NOUN
dti-1319	64	9	to	to	ADP
dti-1319	64	10	its	its	PRON
dti-1319	64	11	cell	cell	NOUN
dti-1319	64	12	-	-	PUNCT
dti-1319	64	13	surface	surface	NOUN
dti-1319	64	14	receptor	receptor	NOUN
dti-1319	64	15	,	,	PUNCT
dti-1319	64	16	the	the	DET
dti-1319	64	17	receptor	receptor	NOUN
dti-1319	64	18	-	-	PUNCT
dti-1319	64	19	oligonucleotide	oligonucleotide	NOUN
dti-1319	64	20	complex	complex	NOUN
dti-1319	64	21	is	be	AUX
dti-1319	64	22	internalized	internalize	VERB
dti-1319	64	23	followed	follow	VERB
dti-1319	64	24	by	by	ADP
dti-1319	64	25	induction	induction	NOUN
dti-1319	64	26	of	of	ADP
dti-1319	64	27	rna	rna	NOUN
dti-1319	64	28	interference	interference	NOUN
dti-1319	64	29	.	.	PUNCT
dti-1319	65	1	186	186	NUM
dti-1319	65	2	ulrich	ulrich	PROPN
dti-1319	65	3	et	et	PROPN
dti-1319	65	4	al	al	PROPN
dti-1319	65	5	drug	drug	PROPN
dti-1319	65	6	target	target	NOUN
dti-1319	65	7	insights	insight	VERB
dti-1319	65	8	2007:2	2007:2	NUM
dti-1319	65	9	systems	system	NOUN
dti-1319	65	10	(	(	PUNCT
dti-1319	65	11	hutvágner	hutvágner	NOUN
dti-1319	65	12	and	and	CCONJ
dti-1319	65	13	zamore	zamore	NOUN
dti-1319	65	14	,	,	PUNCT
dti-1319	65	15	2005	2005	NUM
dti-1319	65	16	)	)	PUNCT
dti-1319	65	17	.	.	PUNCT
dti-1319	66	1	the	the	DET
dti-1319	66	2	interference	interference	NOUN
dti-1319	66	3	effect	effect	NOUN
dti-1319	66	4	of	of	ADP
dti-1319	66	5	dsrna	dsrna	NOUN
dti-1319	66	6	is	be	AUX
dti-1319	66	7	non	non	ADJ
dti-1319	66	8	-	-	ADJ
dti-1319	66	9	stoichiometric	stoichiometric	ADJ
dti-1319	66	10	in	in	ADP
dti-1319	66	11	relation	relation	NOUN
dti-1319	66	12	to	to	ADP
dti-1319	66	13	homologous	homologous	ADJ
dti-1319	66	14	mrna	mrna	PROPN
dti-1319	66	15	,	,	PUNCT
dti-1319	66	16	since	since	SCONJ
dti-1319	66	17	very	very	ADV
dti-1319	66	18	low	low	ADJ
dti-1319	66	19	amounts	amount	NOUN
dti-1319	66	20	of	of	ADP
dti-1319	66	21	dsrna	dsrna	NOUN
dti-1319	66	22	cause	cause	VERB
dti-1319	66	23	strong	strong	ADJ
dti-1319	66	24	interference	interference	NOUN
dti-1319	66	25	.	.	PUNCT
dti-1319	67	1	this	this	PRON
dti-1319	67	2	suggests	suggest	VERB
dti-1319	67	3	that	that	SCONJ
dti-1319	67	4	the	the	DET
dti-1319	67	5	rnai	rnai	PROPN
dti-1319	67	6	effect	effect	NOUN
dti-1319	67	7	involves	involve	VERB
dti-1319	67	8	a	a	DET
dti-1319	67	9	catalytic	catalytic	ADJ
dti-1319	67	10	stage	stage	NOUN
dti-1319	67	11	and	and	CCONJ
dti-1319	67	12	can	can	AUX
dti-1319	67	13	not	not	PART
dti-1319	67	14	be	be	AUX
dti-1319	67	15	based	base	VERB
dti-1319	67	16	on	on	ADP
dti-1319	67	17	the	the	DET
dti-1319	67	18	titration	titration	NOUN
dti-1319	67	19	of	of	ADP
dti-1319	67	20	endogenous	endogenous	ADJ
dti-1319	67	21	mrna	mrna	NOUN
dti-1319	67	22	(	(	PUNCT
dti-1319	67	23	sverdlov	sverdlov	PROPN
dti-1319	67	24	,	,	PUNCT
dti-1319	67	25	2001	2001	NUM
dti-1319	67	26	)	)	PUNCT
dti-1319	67	27	.	.	PUNCT
dti-1319	68	1	therapeutical	therapeutical	ADJ
dti-1319	68	2	applications	application	NOUN
dti-1319	68	3	of	of	ADP
dti-1319	68	4	rnai	rnai	PROPN
dti-1319	68	5	currently	currently	ADV
dti-1319	68	6	,	,	PUNCT
dti-1319	68	7	sirna	sirna	PROPN
dti-1319	68	8	drugs	drug	NOUN
dti-1319	68	9	are	be	AUX
dti-1319	68	10	being	be	AUX
dti-1319	68	11	developed	develop	VERB
dti-1319	68	12	in	in	ADP
dti-1319	68	13	order	order	NOUN
dti-1319	68	14	to	to	PART
dti-1319	68	15	inhibit	inhibit	VERB
dti-1319	68	16	cell	cell	NOUN
dti-1319	68	17	infection	infection	NOUN
dti-1319	68	18	by	by	ADP
dti-1319	68	19	hiv	hiv	PROPN
dti-1319	68	20	(	(	PUNCT
dti-1319	68	21	martinez	martinez	PROPN
dti-1319	68	22	et	et	PROPN
dti-1319	68	23	al	al	PROPN
dti-1319	68	24	.	.	PROPN
dti-1319	68	25	2002	2002	NUM
dti-1319	68	26	)	)	PUNCT
dti-1319	68	27	and	and	CCONJ
dti-1319	68	28	infl	infl	PROPN
dti-1319	68	29	uenza	uenza	PROPN
dti-1319	68	30	viruses	virus	NOUN
dti-1319	68	31	(	(	PUNCT
dti-1319	68	32	ge	ge	PROPN
dti-1319	68	33	et	et	PROPN
dti-1319	68	34	al	al	PROPN
dti-1319	68	35	.	.	PROPN
dti-1319	68	36	2003	2003	NUM
dti-1319	68	37	)	)	PUNCT
dti-1319	68	38	and	and	CCONJ
dti-1319	68	39	to	to	PART
dti-1319	68	40	treat	treat	VERB
dti-1319	68	41	autoimmune	autoimmune	ADJ
dti-1319	68	42	hepatitis	hepatitis	PROPN
dti-1319	68	43	(	(	PUNCT
dti-1319	68	44	song	song	NOUN
dti-1319	68	45	et	et	PROPN
dti-1319	68	46	al	al	PROPN
dti-1319	68	47	.	.	PROPN
dti-1319	68	48	2003	2003	NUM
dti-1319	68	49	)	)	PUNCT
dti-1319	68	50	(	(	PUNCT
dti-1319	68	51	fig	fig	NOUN
dti-1319	68	52	.	.	PUNCT
dti-1319	68	53	1b	1b	NUM
dti-1319	68	54	)	)	PUNCT
dti-1319	68	55	.	.	PUNCT
dti-1319	69	1	rnai	rnai	PROPN
dti-1319	69	2	has	have	AUX
dti-1319	69	3	also	also	ADV
dti-1319	69	4	been	be	AUX
dti-1319	69	5	used	use	VERB
dti-1319	69	6	as	as	ADP
dti-1319	69	7	a	a	DET
dti-1319	69	8	tool	tool	NOUN
dti-1319	69	9	to	to	PART
dti-1319	69	10	study	study	VERB
dti-1319	69	11	signaling	signal	VERB
dti-1319	69	12	pathways	pathway	NOUN
dti-1319	69	13	involved	involve	VERB
dti-1319	69	14	in	in	ADP
dti-1319	69	15	neurogenesis	neurogenesis	NOUN
dti-1319	69	16	and	and	CCONJ
dti-1319	69	17	neurodegeneration	neurodegeneration	NOUN
dti-1319	69	18	(	(	PUNCT
dti-1319	69	19	miller	miller	PROPN
dti-1319	69	20	et	et	PROPN
dti-1319	69	21	al	al	PROPN
dti-1319	69	22	.	.	PROPN
dti-1319	69	23	2005	2005	NUM
dti-1319	69	24	)	)	PUNCT
dti-1319	69	25	.	.	PUNCT
dti-1319	70	1	as	as	ADP
dti-1319	70	2	an	an	DET
dti-1319	70	3	example	example	NOUN
dti-1319	70	4	,	,	PUNCT
dti-1319	70	5	the	the	DET
dti-1319	70	6	function	function	NOUN
dti-1319	70	7	of	of	ADP
dti-1319	70	8	vascular	vascular	ADJ
dti-1319	70	9	endothelial	endothelial	ADJ
dti-1319	70	10	growth	growth	NOUN
dti-1319	70	11	factor	factor	NOUN
dti-1319	70	12	(	(	PUNCT
dti-1319	70	13	vegf	vegf	PROPN
dti-1319	70	14	)	)	PUNCT
dti-1319	70	15	in	in	ADP
dti-1319	70	16	directing	direct	VERB
dti-1319	70	17	neurogenesis	neurogenesis	NOUN
dti-1319	70	18	was	be	AUX
dti-1319	70	19	verifi	verifi	PROPN
dti-1319	70	20	ed	ed	PROPN
dti-1319	70	21	via	via	ADP
dti-1319	70	22	rnai	rnai	PROPN
dti-1319	70	23	(	(	PUNCT
dti-1319	70	24	cao	cao	PROPN
dti-1319	70	25	et	et	PROPN
dti-1319	70	26	al	al	PROPN
dti-1319	70	27	.	.	PROPN
dti-1319	70	28	2004	2004	NUM
dti-1319	70	29	)	)	PUNCT
dti-1319	70	30	.	.	PUNCT
dti-1319	71	1	another	another	DET
dti-1319	71	2	approach	approach	NOUN
dti-1319	71	3	uses	use	VERB
dti-1319	71	4	adenoviral	adenoviral	NOUN
dti-1319	71	5	,	,	PUNCT
dti-1319	71	6	lentiviral	lentiviral	ADJ
dti-1319	71	7	and	and	CCONJ
dti-1319	71	8	aav	aav	NOUN
dti-1319	71	9	(	(	PUNCT
dti-1319	71	10	adeno	adeno	NOUN
dti-1319	71	11	-	-	PUNCT
dti-1319	71	12	associated	associate	VERB
dti-1319	71	13	viral	viral	ADJ
dti-1319	71	14	)	)	PUNCT
dti-1319	71	15	delivery	delivery	NOUN
dti-1319	71	16	systems	system	NOUN
dti-1319	71	17	(	(	PUNCT
dti-1319	71	18	chen	chen	PROPN
dti-1319	71	19	et	et	PROPN
dti-1319	71	20	al	al	PROPN
dti-1319	71	21	.	.	PROPN
dti-1319	71	22	2006	2006	NUM
dti-1319	71	23	)	)	PUNCT
dti-1319	71	24	to	to	PART
dti-1319	71	25	treat	treat	VERB
dti-1319	71	26	spinocebellar	spinocebellar	ADJ
dti-1319	71	27	ataxia	ataxia	NOUN
dti-1319	71	28	(	(	PUNCT
dti-1319	71	29	xia	xia	PROPN
dti-1319	71	30	et	et	PROPN
dti-1319	71	31	al	al	PROPN
dti-1319	71	32	.	.	PROPN
dti-1319	71	33	2004	2004	NUM
dti-1319	71	34	)	)	PUNCT
dti-1319	71	35	,	,	PUNCT
dti-1319	71	36	amyotrophic	amyotrophic	ADJ
dti-1319	71	37	lateral	lateral	ADJ
dti-1319	71	38	sclerosis	sclerosis	NOUN
dti-1319	71	39	(	(	PUNCT
dti-1319	71	40	als	als	NOUN
dti-1319	71	41	)	)	PUNCT
dti-1319	71	42	(	(	PUNCT
dti-1319	71	43	ralph	ralph	PROPN
dti-1319	71	44	et	et	PROPN
dti-1319	71	45	al	al	PROPN
dti-1319	71	46	.	.	PROPN
dti-1319	71	47	2005	2005	NUM
dti-1319	71	48	;	;	PUNCT
dti-1319	71	49	raoul	raoul	PROPN
dti-1319	71	50	et	et	PROPN
dti-1319	71	51	al	al	PROPN
dti-1319	71	52	.	.	PROPN
dti-1319	71	53	2005	2005	NUM
dti-1319	71	54	)	)	PUNCT
dti-1319	71	55	,	,	PUNCT
dti-1319	71	56	huntington´s	huntington´s	PROPN
dti-1319	71	57	(	(	PUNCT
dti-1319	71	58	harper	harper	NOUN
dti-1319	71	59	et	et	PROPN
dti-1319	71	60	al	al	PROPN
dti-1319	71	61	.	.	PROPN
dti-1319	71	62	2005	2005	NUM
dti-1319	71	63	;	;	PUNCT
dti-1319	71	64	rodriguez	rodriguez	NOUN
dti-1319	71	65	-	-	PUNCT
dti-1319	71	66	lebron	lebron	PROPN
dti-1319	71	67	et	et	PROPN
dti-1319	71	68	al	al	PROPN
dti-1319	71	69	.	.	PROPN
dti-1319	71	70	2006	2006	NUM
dti-1319	71	71	)	)	PUNCT
dti-1319	71	72	and	and	CCONJ
dti-1319	71	73	alzheimer	alzheimer	PROPN
dti-1319	71	74	’s	’s	PART
dti-1319	71	75	disease	disease	NOUN
dti-1319	71	76	(	(	PUNCT
dti-1319	71	77	singer	singer	NOUN
dti-1319	71	78	et	et	NOUN
dti-1319	71	79	al	al	PROPN
dti-1319	71	80	.	.	PROPN
dti-1319	71	81	2005	2005	NUM
dti-1319	71	82	)	)	PUNCT
dti-1319	71	83	.	.	PUNCT
dti-1319	72	1	when	when	SCONJ
dti-1319	72	2	compared	compare	VERB
dti-1319	72	3	to	to	ADP
dti-1319	72	4	other	other	ADJ
dti-1319	72	5	gene	gene	NOUN
dti-1319	72	6	ablation	ablation	NOUN
dti-1319	72	7	tools	tool	NOUN
dti-1319	72	8	such	such	ADJ
dti-1319	72	9	as	as	ADP
dti-1319	72	10	antinsense	antinsense	NOUN
dti-1319	72	11	oligonucleotides	oligonucleotide	NOUN
dti-1319	72	12	,	,	PUNCT
dti-1319	72	13	sirnas	sirna	NOUN
dti-1319	72	14	are	be	AUX
dti-1319	72	15	notably	notably	ADV
dti-1319	72	16	superior	superior	ADJ
dti-1319	72	17	due	due	ADP
dti-1319	72	18	to	to	ADP
dti-1319	72	19	their	their	PRON
dti-1319	72	20	higher	high	ADJ
dti-1319	72	21	degree	degree	NOUN
dti-1319	72	22	of	of	ADP
dti-1319	72	23	mrna	mrna	PROPN
dti-1319	72	24	degradation	degradation	NOUN
dti-1319	72	25	and	and	CCONJ
dti-1319	72	26	low	low	ADJ
dti-1319	72	27	potential	potential	NOUN
dti-1319	72	28	of	of	ADP
dti-1319	72	29	inducting	induct	VERB
dti-1319	72	30	immune	immune	ADJ
dti-1319	72	31	responses	response	NOUN
dti-1319	72	32	(	(	PUNCT
dti-1319	72	33	bertrand	bertrand	PROPN
dti-1319	72	34	et	et	PROPN
dti-1319	72	35	al	al	PROPN
dti-1319	72	36	.	.	PROPN
dti-1319	72	37	2002	2002	NUM
dti-1319	72	38	)	)	PUNCT
dti-1319	72	39	.	.	PUNCT
dti-1319	73	1	since	since	SCONJ
dti-1319	73	2	sirnas	sirnas	PROPN
dti-1319	73	3	molecules	molecule	NOUN
dti-1319	73	4	are	be	AUX
dti-1319	73	5	not	not	PART
dti-1319	73	6	integrated	integrate	VERB
dti-1319	73	7	in	in	ADP
dti-1319	73	8	the	the	DET
dti-1319	73	9	genome	genome	NOUN
dti-1319	73	10	as	as	SCONJ
dti-1319	73	11	plasmids	plasmid	NOUN
dti-1319	73	12	potentially	potentially	ADV
dti-1319	73	13	are	be	AUX
dti-1319	73	14	,	,	PUNCT
dti-1319	73	15	they	they	PRON
dti-1319	73	16	cause	cause	VERB
dti-1319	73	17	collateral	collateral	ADJ
dti-1319	73	18	effects	effect	NOUN
dti-1319	73	19	and	and	CCONJ
dti-1319	73	20	thus	thus	ADV
dti-1319	73	21	are	be	AUX
dti-1319	73	22	much	much	ADV
dti-1319	73	23	more	more	ADV
dti-1319	73	24	therapeutically	therapeutically	ADV
dti-1319	73	25	advantageous	advantageous	ADJ
dti-1319	73	26	.	.	PUNCT
dti-1319	74	1	small	small	ADJ
dti-1319	74	2	-	-	PUNCT
dti-1319	74	3	interfering	interfere	VERB
dti-1319	74	4	rnas	rna	NOUN
dti-1319	74	5	do	do	AUX
dti-1319	74	6	not	not	PART
dti-1319	74	7	need	need	VERB
dti-1319	74	8	to	to	PART
dti-1319	74	9	be	be	AUX
dti-1319	74	10	transferred	transfer	VERB
dti-1319	74	11	into	into	ADP
dti-1319	74	12	the	the	DET
dti-1319	74	13	nucleus	nucleus	NOUN
dti-1319	74	14	in	in	ADP
dti-1319	74	15	order	order	NOUN
dti-1319	74	16	to	to	PART
dti-1319	74	17	present	present	ADJ
dti-1319	74	18	activity	activity	NOUN
dti-1319	74	19	,	,	PUNCT
dti-1319	74	20	requiring	require	VERB
dti-1319	74	21	less	less	ADV
dti-1319	74	22	sophisticated	sophisticated	ADJ
dti-1319	74	23	delivery	delivery	NOUN
dti-1319	74	24	systems	system	NOUN
dti-1319	74	25	.	.	PUNCT
dti-1319	75	1	in	in	ADP
dti-1319	75	2	addition	addition	NOUN
dti-1319	75	3	,	,	PUNCT
dti-1319	75	4	due	due	ADP
dti-1319	75	5	to	to	ADP
dti-1319	75	6	their	their	PRON
dti-1319	75	7	relative	relative	ADJ
dti-1319	75	8	small	small	ADJ
dti-1319	75	9	size	size	NOUN
dti-1319	75	10	,	,	PUNCT
dti-1319	75	11	the	the	DET
dti-1319	75	12	delivery	delivery	NOUN
dti-1319	75	13	of	of	ADP
dti-1319	75	14	a	a	DET
dti-1319	75	15	cocktail	cocktail	NOUN
dti-1319	75	16	of	of	ADP
dti-1319	75	17	sirnas	sirna	NOUN
dti-1319	75	18	targeting	target	VERB
dti-1319	75	19	the	the	DET
dti-1319	75	20	expression	expression	NOUN
dti-1319	75	21	of	of	ADP
dti-1319	75	22	multiple	multiple	ADJ
dti-1319	75	23	disease	disease	NOUN
dti-1319	75	24	causing	cause	VERB
dti-1319	75	25	genes	gene	NOUN
dti-1319	75	26	at	at	ADP
dti-1319	75	27	the	the	DET
dti-1319	75	28	same	same	ADJ
dti-1319	75	29	time	time	NOUN
dti-1319	75	30	should	should	AUX
dti-1319	75	31	be	be	AUX
dti-1319	75	32	feasible	feasible	ADJ
dti-1319	75	33	.	.	PUNCT
dti-1319	76	1	vegf	vegf	PROPN
dti-1319	76	2	gene	gene	NOUN
dti-1319	76	3	expression	expression	NOUN
dti-1319	76	4	was	be	AUX
dti-1319	76	5	the	the	DET
dti-1319	76	6	fi	fi	NOUN
dti-1319	76	7	rst	rst	NOUN
dti-1319	76	8	target	target	NOUN
dti-1319	76	9	for	for	ADP
dti-1319	76	10	clinical	clinical	ADJ
dti-1319	76	11	trials	trial	NOUN
dti-1319	76	12	using	use	VERB
dti-1319	76	13	sirna	sirna	PROPN
dti-1319	76	14	in	in	ADP
dti-1319	76	15	the	the	DET
dti-1319	76	16	treatment	treatment	NOUN
dti-1319	76	17	of	of	ADP
dti-1319	76	18	age	age	NOUN
dti-1319	76	19	-	-	PUNCT
dti-1319	76	20	related	relate	VERB
dti-1319	76	21	macular	macular	ADJ
dti-1319	76	22	degeneration	degeneration	NOUN
dti-1319	76	23	(	(	PUNCT
dti-1319	76	24	amd	amd	PROPN
dti-1319	76	25	)	)	PUNCT
dti-1319	76	26	.	.	PUNCT
dti-1319	77	1	rnai	rnai	PROPN
dti-1319	77	2	is	be	AUX
dti-1319	77	3	also	also	ADV
dti-1319	77	4	being	be	AUX
dti-1319	77	5	used	use	VERB
dti-1319	77	6	to	to	PART
dti-1319	77	7	combat	combat	VERB
dti-1319	77	8	infection	infection	NOUN
dti-1319	77	9	by	by	ADP
dti-1319	77	10	the	the	DET
dti-1319	77	11	respiratory	respiratory	ADJ
dti-1319	77	12	syncytial	syncytial	ADJ
dti-1319	77	13	virus	virus	NOUN
dti-1319	77	14	(	(	PUNCT
dti-1319	77	15	rsv	rsv	PROPN
dti-1319	77	16	)	)	PUNCT
dti-1319	77	17	genome	genome	NOUN
dti-1319	77	18	.	.	PUNCT
dti-1319	78	1	the	the	DET
dti-1319	78	2	vehicle	vehicle	NOUN
dti-1319	78	3	used	use	VERB
dti-1319	78	4	in	in	ADP
dti-1319	78	5	both	both	DET
dti-1319	78	6	cases	case	NOUN
dti-1319	78	7	was	be	AUX
dti-1319	78	8	a	a	DET
dti-1319	78	9	saline	saline	ADJ
dti-1319	78	10	formulation	formulation	NOUN
dti-1319	78	11	.	.	PUNCT
dti-1319	79	1	the	the	DET
dti-1319	79	2	success	success	NOUN
dti-1319	79	3	of	of	ADP
dti-1319	79	4	these	these	DET
dti-1319	79	5	trials	trial	NOUN
dti-1319	79	6	may	may	AUX
dti-1319	79	7	be	be	AUX
dti-1319	79	8	due	due	ADJ
dti-1319	79	9	to	to	ADP
dti-1319	79	10	the	the	DET
dti-1319	79	11	direct	direct	ADJ
dti-1319	79	12	administration	administration	NOUN
dti-1319	79	13	of	of	ADP
dti-1319	79	14	sirnas	sirnas	PROPN
dti-1319	79	15	at	at	ADP
dti-1319	79	16	the	the	DET
dti-1319	79	17	diseased	diseased	ADJ
dti-1319	79	18	organs	organ	NOUN
dti-1319	79	19	.	.	PUNCT
dti-1319	80	1	the	the	DET
dti-1319	80	2	advantage	advantage	NOUN
dti-1319	80	3	of	of	ADP
dti-1319	80	4	the	the	DET
dti-1319	80	5	direct	direct	ADJ
dti-1319	80	6	administration	administration	NOUN
dti-1319	80	7	is	be	AUX
dti-1319	80	8	the	the	DET
dti-1319	80	9	high	high	ADJ
dti-1319	80	10	concentrations	concentration	NOUN
dti-1319	80	11	of	of	ADP
dti-1319	80	12	the	the	DET
dti-1319	80	13	sirna	sirna	PROPN
dti-1319	80	14	available	available	ADJ
dti-1319	80	15	at	at	ADP
dti-1319	80	16	the	the	DET
dti-1319	80	17	target	target	NOUN
dti-1319	80	18	side	side	NOUN
dti-1319	80	19	.	.	PUNCT
dti-1319	81	1	a	a	DET
dti-1319	81	2	sirna	sirna	PROPN
dti-1319	81	3	-	-	PUNCT
dti-1319	81	4	based	base	VERB
dti-1319	81	5	drug	drug	NOUN
dti-1319	81	6	denominated	denominate	VERB
dti-1319	81	7	cand6	cand6	NOUN
dti-1319	81	8	which	which	PRON
dti-1319	81	9	also	also	ADV
dti-1319	81	10	suppresses	suppress	VERB
dti-1319	81	11	vegf	vegf	PROPN
dti-1319	81	12	gene	gene	NOUN
dti-1319	81	13	expression	expression	NOUN
dti-1319	81	14	is	be	AUX
dti-1319	81	15	currently	currently	ADV
dti-1319	81	16	being	be	AUX
dti-1319	81	17	tested	test	VERB
dti-1319	81	18	in	in	ADP
dti-1319	81	19	a	a	DET
dti-1319	81	20	phase	phase	NOUN
dti-1319	81	21	2	2	NUM
dti-1319	81	22	trial	trial	NOUN
dti-1319	81	23	with	with	ADP
dti-1319	81	24	patients	patient	NOUN
dti-1319	81	25	suffering	suffer	VERB
dti-1319	81	26	from	from	ADP
dti-1319	81	27	amd	amd	PROPN
dti-1319	81	28	.	.	PUNCT
dti-1319	82	1	moreover	moreover	ADV
dti-1319	82	2	,	,	PUNCT
dti-1319	82	3	early	early	ADV
dti-1319	82	4	in	in	ADP
dti-1319	82	5	2006	2006	NUM
dti-1319	82	6	,	,	PUNCT
dti-1319	82	7	cand5	cand5	PROPN
dti-1319	82	8	was	be	AUX
dti-1319	82	9	also	also	ADV
dti-1319	82	10	tested	test	VERB
dti-1319	82	11	in	in	ADP
dti-1319	82	12	phase	phase	NOUN
dti-1319	82	13	2	2	NUM
dti-1319	82	14	clinical	clinical	ADJ
dti-1319	82	15	trials	trial	NOUN
dti-1319	82	16	for	for	ADP
dti-1319	82	17	the	the	DET
dti-1319	82	18	treatment	treatment	NOUN
dti-1319	82	19	of	of	ADP
dti-1319	82	20	diabetic	diabetic	ADJ
dti-1319	82	21	macular	macular	ADJ
dti-1319	82	22	edema	edema	NOUN
dti-1319	82	23	(	(	PUNCT
dti-1319	82	24	http://www.acuitypharma.com/	http://www.acuitypharma.com/	NOUN
dti-1319	82	25	)	)	PUNCT
dti-1319	82	26	.	.	PUNCT
dti-1319	83	1	the	the	DET
dti-1319	83	2	sirna	sirna	PROPN
dti-1319	83	3	aln	aln	PROPN
dti-1319	83	4	-	-	PUNCT
dti-1319	83	5	rsv01	rsv01	NOUN
dti-1319	83	6	developed	develop	VERB
dti-1319	83	7	by	by	ADP
dti-1319	83	8	alnylam	alnylam	PROPN
dti-1319	83	9	pharmaceuticals	pharmaceuticals	PROPN
dti-1319	83	10	,	,	PUNCT
dti-1319	83	11	inc	inc	PROPN
dti-1319	83	12	.	.	PROPN
dti-1319	83	13	,	,	PUNCT
dti-1319	83	14	for	for	ADP
dti-1319	83	15	treatment	treatment	NOUN
dti-1319	83	16	of	of	ADP
dti-1319	83	17	rsv	rsv	PROPN
dti-1319	83	18	infection	infection	NOUN
dti-1319	83	19	has	have	AUX
dti-1319	83	20	completed	complete	VERB
dti-1319	83	21	two	two	NUM
dti-1319	83	22	phase	phase	NOUN
dti-1319	83	23	1	1	NUM
dti-1319	83	24	trials	trial	NOUN
dti-1319	83	25	and	and	CCONJ
dti-1319	83	26	now	now	ADV
dti-1319	83	27	appears	appear	VERB
dti-1319	83	28	to	to	PART
dti-1319	83	29	be	be	AUX
dti-1319	83	30	appropriate	appropriate	ADJ
dti-1319	83	31	for	for	ADP
dti-1319	83	32	tests	test	NOUN
dti-1319	83	33	in	in	ADP
dti-1319	83	34	humans	human	NOUN
dti-1319	83	35	.	.	PUNCT
dti-1319	84	1	other	other	ADJ
dti-1319	84	2	sirnas	sirna	NOUN
dti-1319	84	3	targeting	target	VERB
dti-1319	84	4	influenza	influenza	NOUN
dti-1319	84	5	and	and	CCONJ
dti-1319	84	6	hepatitis	hepatitis	NOUN
dti-1319	84	7	c	c	PROPN
dti-1319	84	8	viruses	virus	NOUN
dti-1319	84	9	(	(	PUNCT
dti-1319	84	10	protiva	protiva	NOUN
dti-1319	84	11	biotherapeutics	biotherapeutic	NOUN
dti-1319	84	12	)	)	PUNCT
dti-1319	84	13	are	be	AUX
dti-1319	84	14	expected	expect	VERB
dti-1319	84	15	to	to	PART
dti-1319	84	16	be	be	AUX
dti-1319	84	17	available	available	ADJ
dti-1319	84	18	for	for	ADP
dti-1319	84	19	clinical	clinical	ADJ
dti-1319	84	20	use	use	NOUN
dti-1319	84	21	within	within	ADP
dti-1319	84	22	the	the	DET
dti-1319	84	23	coming	come	VERB
dti-1319	84	24	year	year	NOUN
dti-1319	84	25	(	(	PUNCT
dti-1319	84	26	protiva	protiva	NOUN
dti-1319	84	27	biotherapeutics	biotherapeutic	NOUN
dti-1319	84	28	)	)	PUNCT
dti-1319	84	29	.	.	PUNCT
dti-1319	85	1	stability	stability	NOUN
dti-1319	85	2	of	of	ADP
dti-1319	85	3	sirna	sirna	PROPN
dti-1319	85	4	in	in	ADP
dti-1319	85	5	plasma	plasma	PROPN
dti-1319	85	6	sirna	sirna	PROPN
dti-1319	85	7	molecules	molecule	NOUN
dti-1319	85	8	are	be	AUX
dti-1319	85	9	unstable	unstable	ADJ
dti-1319	85	10	in	in	ADP
dti-1319	85	11	serum	serum	NOUN
dti-1319	85	12	as	as	ADP
dti-1319	85	13	a	a	DET
dti-1319	85	14	result	result	NOUN
dti-1319	85	15	of	of	ADP
dti-1319	85	16	degradation	degradation	NOUN
dti-1319	85	17	by	by	ADP
dti-1319	85	18	serum	serum	NOUN
dti-1319	85	19	nucleases	nuclease	NOUN
dti-1319	85	20	and	and	CCONJ
dti-1319	85	21	thus	thus	ADV
dti-1319	85	22	have	have	VERB
dti-1319	85	23	very	very	ADV
dti-1319	85	24	short	short	ADJ
dti-1319	85	25	half	half	ADJ
dti-1319	85	26	-	-	PUNCT
dti-1319	85	27	lives	life	NOUN
dti-1319	85	28	in	in	ADP
dti-1319	85	29	vivo	vivo	NOUN
dti-1319	85	30	(	(	PUNCT
dti-1319	85	31	soutschek	soutschek	PROPN
dti-1319	85	32	et	et	PROPN
dti-1319	85	33	al	al	PROPN
dti-1319	85	34	.	.	PROPN
dti-1319	85	35	2004	2004	NUM
dti-1319	85	36	)	)	PUNCT
dti-1319	85	37	.	.	PUNCT
dti-1319	86	1	stability	stability	NOUN
dti-1319	86	2	against	against	ADP
dti-1319	86	3	nuclease	nuclease	NOUN
dti-1319	86	4	degradation	degradation	NOUN
dti-1319	86	5	can	can	AUX
dti-1319	86	6	be	be	AUX
dti-1319	86	7	achieved	achieve	VERB
dti-1319	86	8	by	by	ADP
dti-1319	86	9	introducing	introduce	VERB
dti-1319	86	10	a	a	DET
dti-1319	86	11	phosphorothioate	phosphorothioate	NOUN
dti-1319	86	12	(	(	PUNCT
dti-1319	86	13	p	p	NOUN
dti-1319	86	14	=	=	SYM
dti-1319	86	15	s	s	NOUN
dti-1319	86	16	)	)	PUNCT
dti-1319	86	17	backbone	backbone	NOUN
dti-1319	86	18	linkage	linkage	NOUN
dti-1319	86	19	at	at	ADP
dti-1319	86	20	the	the	DET
dti-1319	86	21	3′	3′	NUM
dti-1319	86	22	end	end	NOUN
dti-1319	86	23	for	for	ADP
dti-1319	86	24	exonuclease	exonuclease	NOUN
dti-1319	86	25	resistance	resistance	NOUN
dti-1319	86	26	and	and	CCONJ
dti-1319	86	27	2′	2′	NUM
dti-1319	86	28	�	�	PROPN
dti-1319	86	29	modifi	modifi	NOUN
dti-1319	86	30	cations	cation	NOUN
dti-1319	86	31	(	(	PUNCT
dti-1319	86	32	2′-ome	2′-ome	NUM
dti-1319	86	33	,	,	PUNCT
dti-1319	86	34	2′-f	2′-f	NOUN
dti-1319	86	35	or	or	CCONJ
dti-1319	86	36	related	relate	VERB
dti-1319	86	37	)	)	PUNCT
dti-1319	86	38	for	for	ADP
dti-1319	86	39	endonuclease	endonuclease	NOUN
dti-1319	86	40	resistance	resistance	NOUN
dti-1319	86	41	(	(	PUNCT
dti-1319	86	42	vornlocher	vornlocher	NOUN
dti-1319	86	43	et	et	PROPN
dti-1319	86	44	al	al	PROPN
dti-1319	86	45	.	.	PROPN
dti-1319	86	46	2005	2005	NUM
dti-1319	86	47	;	;	PUNCT
dti-1319	86	48	li	li	PROPN
dti-1319	86	49	et	et	PROPN
dti-1319	86	50	al	al	PROPN
dti-1319	86	51	.	.	PROPN
dti-1319	86	52	2005	2005	NUM
dti-1319	86	53	;	;	PUNCT
dti-1319	86	54	choung	choung	NOUN
dti-1319	86	55	et	et	PROPN
dti-1319	86	56	al	al	PROPN
dti-1319	86	57	.	.	PROPN
dti-1319	86	58	2006	2006	NUM
dti-1319	86	59	)	)	PUNCT
dti-1319	86	60	.	.	PUNCT
dti-1319	87	1	moreover	moreover	ADV
dti-1319	87	2	,	,	PUNCT
dti-1319	87	3	sirna	sirna	PROPN
dti-1319	87	4	molecules	molecule	NOUN
dti-1319	87	5	consisting	consist	VERB
dti-1319	87	6	entirely	entirely	ADV
dti-1319	87	7	of	of	ADP
dti-1319	87	8	2′-o	2′-o	NUM
dti-1319	87	9	-	-	PUNCT
dti-1319	87	10	methyl	methyl	NOUN
dti-1319	87	11	and	and	CCONJ
dti-1319	87	12	2′-fl	2′-fl	NUM
dti-1319	87	13	uoro	uoro	NOUN
dti-1319	87	14	-	-	PUNCT
dti-1319	87	15	modifi	modifi	NOUN
dti-1319	87	16	ed	ed	PROPN
dti-1319	87	17	nucleotides	nucleotide	NOUN
dti-1319	87	18	demonstrated	demonstrate	VERB
dti-1319	87	19	enhanced	enhanced	ADJ
dti-1319	87	20	plasma	plasma	NOUN
dti-1319	87	21	stability	stability	NOUN
dti-1319	87	22	and	and	CCONJ
dti-1319	87	23	increased	increase	VERB
dti-1319	87	24	in	in	ADP
dti-1319	87	25	vitro	vitro	X
dti-1319	87	26	potency	potency	NOUN
dti-1319	87	27	.	.	PUNCT
dti-1319	88	1	duplexes	duplex	NOUN
dti-1319	88	2	containing	contain	VERB
dti-1319	88	3	the	the	DET
dti-1319	88	4	4′-thioribose	4′-thioribose	NUM
dti-1319	88	5	modifi	modifi	NOUN
dti-1319	88	6	cation	cation	NOUN
dti-1319	88	7	present	present	NOUN
dti-1319	88	8	increased	increase	VERB
dti-1319	88	9	thermal	thermal	ADJ
dti-1319	88	10	stability	stability	NOUN
dti-1319	88	11	and	and	CCONJ
dti-1319	88	12	are	be	AUX
dti-1319	88	13	600	600	NUM
dti-1319	88	14	fold	fold	NOUN
dti-1319	88	15	more	more	ADV
dti-1319	88	16	resistant	resistant	ADJ
dti-1319	88	17	to	to	ADP
dti-1319	88	18	degradation	degradation	NOUN
dti-1319	88	19	in	in	ADP
dti-1319	88	20	plasma	plasma	NOUN
dti-1319	88	21	than	than	ADP
dti-1319	88	22	natural	natural	ADJ
dti-1319	88	23	rna	rna	NOUN
dti-1319	88	24	duplexes	duplex	NOUN
dti-1319	88	25	are	be	AUX
dti-1319	88	26	(	(	PUNCT
dti-1319	88	27	hoshika	hoshika	X
dti-1319	88	28	et	et	PROPN
dti-1319	88	29	al	al	PROPN
dti-1319	88	30	.	.	PROPN
dti-1319	88	31	2004	2004	NUM
dti-1319	88	32	)	)	PUNCT
dti-1319	88	33	.	.	PUNCT
dti-1319	89	1	substantial	substantial	ADJ
dti-1319	89	2	improvements	improvement	NOUN
dti-1319	89	3	in	in	ADP
dti-1319	89	4	sirna	sirna	PROPN
dti-1319	89	5	activity	activity	NOUN
dti-1319	89	6	and	and	CCONJ
dti-1319	89	7	plasma	plasma	NOUN
dti-1319	89	8	stability	stability	NOUN
dti-1319	89	9	have	have	AUX
dti-1319	89	10	also	also	ADV
dti-1319	89	11	been	be	AUX
dti-1319	89	12	achieved	achieve	VERB
dti-1319	89	13	by	by	ADP
dti-1319	89	14	judicious	judicious	ADJ
dti-1319	89	15	combination	combination	NOUN
dti-1319	89	16	of	of	ADP
dti-1319	89	17	4′-thioribose	4′-thioribose	NUM
dti-1319	89	18	with	with	ADP
dti-1319	89	19	2′-o	2′-o	NUM
dti-1319	89	20	-	-	PUNCT
dti-1319	89	21	me	i	PRON
dti-1319	89	22	and	and	CCONJ
dti-1319	89	23	2′-o	2′-o	NUM
dti-1319	89	24	-	-	PUNCT
dti-1319	89	25	methoxyethyl	methoxyethyl	NOUN
dti-1319	89	26	modifi	modifi	NOUN
dti-1319	89	27	cations	cation	NOUN
dti-1319	89	28	(	(	PUNCT
dti-1319	89	29	dande	dande	NOUN
dti-1319	89	30	et	et	PROPN
dti-1319	89	31	al	al	PROPN
dti-1319	89	32	.	.	PROPN
dti-1319	89	33	2006	2006	NUM
dti-1319	89	34	)	)	PUNCT
dti-1319	89	35	.	.	PUNCT
dti-1319	90	1	aptamers	aptamer	NOUN
dti-1319	90	2	aptamers	aptamer	NOUN
dti-1319	90	3	are	be	AUX
dti-1319	90	4	oligonucleotides	oligonucleotide	NOUN
dti-1319	90	5	identifi	identifi	PROPN
dti-1319	90	6	ed	ed	NOUN
dti-1319	90	7	by	by	ADP
dti-1319	90	8	an	an	DET
dti-1319	90	9	in	in	ADP
dti-1319	90	10	vitro	vitro	X
dti-1319	90	11	selection	selection	NOUN
dti-1319	90	12	process	process	NOUN
dti-1319	90	13	as	as	ADP
dti-1319	90	14	high	high	ADJ
dti-1319	90	15	-	-	PUNCT
dti-1319	90	16	affi	affi	NOUN
dti-1319	90	17	nity	nity	NOUN
dti-1319	90	18	binders	binder	NOUN
dti-1319	90	19	to	to	ADP
dti-1319	90	20	a	a	DET
dti-1319	90	21	given	give	VERB
dti-1319	90	22	target	target	NOUN
dti-1319	90	23	molecule	molecule	NOUN
dti-1319	90	24	.	.	PUNCT
dti-1319	91	1	for	for	ADP
dti-1319	91	2	this	this	DET
dti-1319	91	3	purpose	purpose	NOUN
dti-1319	91	4	,	,	PUNCT
dti-1319	91	5	a	a	DET
dti-1319	91	6	dna	dna	PROPN
dti-1319	91	7	library	library	NOUN
dti-1319	91	8	is	be	AUX
dti-1319	91	9	synthesized	synthesize	VERB
dti-1319	91	10	containing	contain	VERB
dti-1319	91	11	an	an	DET
dti-1319	91	12	inner	inner	ADJ
dti-1319	91	13	randomized	randomized	ADJ
dti-1319	91	14	sequence	sequence	NOUN
dti-1319	91	15	of	of	ADP
dti-1319	91	16	typically	typically	ADV
dti-1319	91	17	20–100	20–100	NUM
dti-1319	91	18	nucleotides	nucleotide	NOUN
dti-1319	91	19	fl	fl	NOUN
dti-1319	91	20	anked	anke	VERB
dti-1319	91	21	by	by	ADP
dti-1319	91	22	two	two	NUM
dti-1319	91	23	outer	outer	ADJ
dti-1319	91	24	constant	constant	ADJ
dti-1319	91	25	regions	region	NOUN
dti-1319	91	26	of	of	ADP
dti-1319	91	27	20–40	20–40	NUM
dti-1319	91	28	nucleotides	nucleotide	NOUN
dti-1319	91	29	.	.	PUNCT
dti-1319	92	1	a	a	DET
dti-1319	92	2	t7	t7	PROPN
dti-1319	92	3	promoter	promoter	NOUN
dti-1319	92	4	site	site	NOUN
dti-1319	92	5	is	be	AUX
dti-1319	92	6	incorporated	incorporate	VERB
dti-1319	92	7	in	in	ADP
dti-1319	92	8	one	one	NUM
dti-1319	92	9	of	of	ADP
dti-1319	92	10	the	the	DET
dti-1319	92	11	constant	constant	ADJ
dti-1319	92	12	sequences	sequence	NOUN
dti-1319	92	13	,	,	PUNCT
dti-1319	92	14	if	if	SCONJ
dti-1319	92	15	a	a	DET
dti-1319	92	16	rna	rna	NOUN
dti-1319	92	17	aptamer	aptamer	NOUN
dti-1319	92	18	is	be	AUX
dti-1319	92	19	to	to	PART
dti-1319	92	20	be	be	AUX
dti-1319	92	21	selected	select	VERB
dti-1319	92	22	.	.	PUNCT
dti-1319	93	1	the	the	DET
dti-1319	93	2	chemically	chemically	ADV
dti-1319	93	3	synthesized	synthesize	VERB
dti-1319	93	4	dna	dna	NOUN
dti-1319	93	5	pool	pool	NOUN
dti-1319	93	6	is	be	AUX
dti-1319	93	7	amplified	amplify	VERB
dti-1319	93	8	by	by	ADP
dti-1319	93	9	pcr	pcr	PROPN
dti-1319	93	10	in	in	ADP
dti-1319	93	11	the	the	DET
dti-1319	93	12	presence	presence	NOUN
dti-1319	93	13	of	of	ADP
dti-1319	93	14	senseand	senseand	ADJ
dti-1319	93	15	anti	anti	ADJ
dti-1319	93	16	-	-	ADJ
dti-1319	93	17	sense	sense	ADJ
dti-1319	93	18	-	-	PUNCT
dti-1319	93	19	primers	primer	NOUN
dti-1319	93	20	.	.	PUNCT
dti-1319	94	1	the	the	DET
dti-1319	94	2	dna	dna	PROPN
dti-1319	94	3	template	template	NOUN
dti-1319	94	4	can	can	AUX
dti-1319	94	5	now	now	ADV
dti-1319	94	6	either	either	CCONJ
dti-1319	94	7	be	be	AUX
dti-1319	94	8	transcribed	transcribe	VERB
dti-1319	94	9	in	in	ADP
dti-1319	94	10	vitro	vitro	X
dti-1319	94	11	to	to	ADP
dti-1319	94	12	the	the	DET
dti-1319	94	13	rna	rna	NOUN
dti-1319	94	14	187	187	NUM
dti-1319	94	15	delivery	delivery	NOUN
dti-1319	94	16	systems	system	NOUN
dti-1319	94	17	of	of	ADP
dti-1319	94	18	nucleic	nucleic	ADJ
dti-1319	94	19	acids	acid	NOUN
dti-1319	94	20	drugs	drug	NOUN
dti-1319	94	21	drug	drug	NOUN
dti-1319	94	22	target	target	NOUN
dti-1319	94	23	insights	insight	VERB
dti-1319	94	24	2007:2	2007:2	NUM
dti-1319	94	25	pool	pool	NOUN
dti-1319	94	26	or	or	CCONJ
dti-1319	94	27	be	be	AUX
dti-1319	94	28	denatured	denature	VERB
dti-1319	94	29	to	to	PART
dti-1319	94	30	originate	originate	VERB
dti-1319	94	31	a	a	DET
dti-1319	94	32	single	single	ADJ
dti-1319	94	33	-	-	PUNCT
dti-1319	94	34	stranded	strand	VERB
dti-1319	94	35	(	(	PUNCT
dti-1319	94	36	ss	ss	NOUN
dti-1319	94	37	)	)	PUNCT
dti-1319	94	38	dna	dna	PROPN
dti-1319	94	39	pool	pool	NOUN
dti-1319	94	40	to	to	PART
dti-1319	94	41	be	be	AUX
dti-1319	94	42	used	use	VERB
dti-1319	94	43	in	in	ADP
dti-1319	94	44	the	the	DET
dti-1319	94	45	in	in	ADV
dti-1319	94	46	vitro	vitro	X
dti-1319	94	47	selection	selection	NOUN
dti-1319	94	48	process	process	NOUN
dti-1319	94	49	.	.	PUNCT
dti-1319	95	1	in	in	ADP
dti-1319	95	2	many	many	ADJ
dti-1319	95	3	cases	case	NOUN
dti-1319	95	4	2′-f	2′-f	NOUN
dti-1319	95	5	-	-	PUNCT
dti-1319	95	6	modifi	modifi	NOUN
dti-1319	95	7	ed	ed	PROPN
dti-1319	95	8	pyrimidines	pyrimidine	NOUN
dti-1319	95	9	are	be	AUX
dti-1319	95	10	employed	employ	VERB
dti-1319	95	11	in	in	ADP
dti-1319	95	12	the	the	DET
dti-1319	95	13	in	in	ADV
dti-1319	95	14	vitro	vitro	X
dti-1319	95	15	transcription	transcription	NOUN
dti-1319	95	16	reaction	reaction	NOUN
dti-1319	95	17	to	to	PART
dti-1319	95	18	improve	improve	VERB
dti-1319	95	19	nuclease	nuclease	NOUN
dti-1319	95	20	-	-	PUNCT
dti-1319	95	21	resistance	resistance	NOUN
dti-1319	95	22	of	of	ADP
dti-1319	95	23	generated	generate	VERB
dti-1319	95	24	rna	rna	NOUN
dti-1319	95	25	molecules	molecule	NOUN
dti-1319	95	26	(	(	PUNCT
dti-1319	95	27	reviewed	review	VERB
dti-1319	95	28	by	by	ADP
dti-1319	95	29	ulrich	ulrich	PROPN
dti-1319	95	30	et	et	PROPN
dti-1319	95	31	al	al	PROPN
dti-1319	95	32	.	.	PROPN
dti-1319	95	33	2004	2004	NUM
dti-1319	95	34	)	)	PUNCT
dti-1319	95	35	.	.	PUNCT
dti-1319	96	1	reiterative	reiterative	ADJ
dti-1319	96	2	cycles	cycle	NOUN
dti-1319	96	3	of	of	ADP
dti-1319	96	4	in	in	ADP
dti-1319	96	5	vitro	vitro	X
dti-1319	96	6	selection	selection	NOUN
dti-1319	96	7	,	,	PUNCT
dti-1319	96	8	also	also	ADV
dti-1319	96	9	denominated	denominate	VERB
dti-1319	96	10	as	as	ADP
dti-1319	96	11	systematic	systematic	ADJ
dti-1319	96	12	evolution	evolution	NOUN
dti-1319	96	13	of	of	ADP
dti-1319	96	14	ligands	ligand	NOUN
dti-1319	96	15	by	by	ADP
dti-1319	96	16	exponential	exponential	ADJ
dti-1319	96	17	enrichment	enrichment	NOUN
dti-1319	96	18	(	(	PUNCT
dti-1319	96	19	selex	selex	NOUN
dti-1319	96	20	)	)	PUNCT
dti-1319	96	21	,	,	PUNCT
dti-1319	96	22	are	be	AUX
dti-1319	96	23	carried	carry	VERB
dti-1319	96	24	out	out	ADP
dti-1319	96	25	by	by	ADP
dti-1319	96	26	incubating	incubate	VERB
dti-1319	96	27	the	the	DET
dti-1319	96	28	target	target	NOUN
dti-1319	96	29	protein	protein	NOUN
dti-1319	96	30	or	or	CCONJ
dti-1319	96	31	another	another	DET
dti-1319	96	32	molecule	molecule	NOUN
dti-1319	96	33	of	of	ADP
dti-1319	96	34	biological	biological	ADJ
dti-1319	96	35	importance	importance	NOUN
dti-1319	96	36	with	with	ADP
dti-1319	96	37	the	the	DET
dti-1319	96	38	combinatorial	combinatorial	ADJ
dti-1319	96	39	dna	dna	NOUN
dti-1319	96	40	or	or	CCONJ
dti-1319	96	41	rna	rna	NOUN
dti-1319	96	42	pool	pool	NOUN
dti-1319	96	43	,	,	PUNCT
dti-1319	96	44	followed	follow	VERB
dti-1319	96	45	by	by	ADP
dti-1319	96	46	elution	elution	NOUN
dti-1319	96	47	and	and	CCONJ
dti-1319	96	48	amplifi	amplifi	NOUN
dti-1319	96	49	cation	cation	NOUN
dti-1319	96	50	of	of	ADP
dti-1319	96	51	target	target	NOUN
dti-1319	96	52	binders	binder	NOUN
dti-1319	96	53	by	by	ADP
dti-1319	96	54	rt	rt	PROPN
dti-1319	96	55	-	-	PUNCT
dti-1319	96	56	pcr	pcr	ADJ
dti-1319	96	57	or	or	CCONJ
dti-1319	96	58	pcr	pcr	ADJ
dti-1319	96	59	techniques	technique	NOUN
dti-1319	96	60	.	.	PUNCT
dti-1319	97	1	selection	selection	NOUN
dti-1319	97	2	stringency	stringency	NOUN
dti-1319	97	3	is	be	AUX
dti-1319	97	4	increased	increase	VERB
dti-1319	97	5	with	with	ADP
dti-1319	97	6	the	the	DET
dti-1319	97	7	numbers	number	NOUN
dti-1319	97	8	of	of	ADP
dti-1319	97	9	selex	selex	PROPN
dti-1319	97	10	cycles	cycle	NOUN
dti-1319	97	11	.	.	PUNCT
dti-1319	98	1	increased	increase	VERB
dti-1319	98	2	stringency	stringency	NOUN
dti-1319	98	3	can	can	AUX
dti-1319	98	4	be	be	AUX
dti-1319	98	5	achieved	achieve	VERB
dti-1319	98	6	by	by	ADP
dti-1319	98	7	augmenting	augment	VERB
dti-1319	98	8	the	the	DET
dti-1319	98	9	number	number	NOUN
dti-1319	98	10	of	of	ADP
dti-1319	98	11	dna	dna	NOUN
dti-1319	98	12	or	or	CCONJ
dti-1319	98	13	rna	rna	NOUN
dti-1319	98	14	molecules	molecule	NOUN
dti-1319	98	15	relative	relative	ADJ
dti-1319	98	16	to	to	ADP
dti-1319	98	17	possible	possible	ADJ
dti-1319	98	18	target	target	NOUN
dti-1319	98	19	binding	bind	VERB
dti-1319	98	20	sites	site	NOUN
dti-1319	98	21	as	as	ADV
dti-1319	98	22	well	well	ADV
dti-1319	98	23	as	as	ADP
dti-1319	98	24	by	by	ADP
dti-1319	98	25	extensive	extensive	ADJ
dti-1319	98	26	washing	washing	NOUN
dti-1319	98	27	for	for	ADP
dti-1319	98	28	removal	removal	NOUN
dti-1319	98	29	of	of	ADP
dti-1319	98	30	low	low	ADJ
dti-1319	98	31	-	-	PUNCT
dti-1319	98	32	affi	affi	NOUN
dti-1319	98	33	nity	nity	NOUN
dti-1319	98	34	binders	binder	NOUN
dti-1319	98	35	.	.	PUNCT
dti-1319	99	1	these	these	DET
dti-1319	99	2	procedures	procedure	NOUN
dti-1319	99	3	ensure	ensure	VERB
dti-1319	99	4	that	that	SCONJ
dti-1319	99	5	the	the	DET
dti-1319	99	6	original	original	ADJ
dti-1319	99	7	random	random	ADJ
dti-1319	99	8	pool	pool	NOUN
dti-1319	99	9	containing	contain	VERB
dti-1319	99	10	1013–1015	1013–1015	NUM
dti-1319	99	11	different	different	ADJ
dti-1319	99	12	sequences	sequence	NOUN
dti-1319	99	13	becomes	becomes	AUX
dti-1319	99	14	narrowed	narrow	VERB
dti-1319	99	15	down	down	ADP
dti-1319	99	16	to	to	ADP
dti-1319	99	17	a	a	DET
dti-1319	99	18	more	more	ADV
dti-1319	99	19	homogenous	homogenous	ADJ
dti-1319	99	20	population	population	NOUN
dti-1319	99	21	of	of	ADP
dti-1319	99	22	high	high	ADJ
dti-1319	99	23	-	-	PUNCT
dti-1319	99	24	affi	affi	NOUN
dti-1319	99	25	nity	nity	NOUN
dti-1319	99	26	target	target	NOUN
dti-1319	99	27	binders	binder	NOUN
dti-1319	99	28	.	.	PUNCT
dti-1319	100	1	when	when	SCONJ
dti-1319	100	2	the	the	DET
dti-1319	100	3	binding	bind	VERB
dti-1319	100	4	affi	affi	ADJ
dti-1319	100	5	nity	nity	NOUN
dti-1319	100	6	of	of	ADP
dti-1319	100	7	a	a	DET
dti-1319	100	8	selected	select	VERB
dti-1319	100	9	rna	rna	NOUN
dti-1319	100	10	or	or	CCONJ
dti-1319	100	11	dna	dna	PROPN
dti-1319	100	12	library	library	NOUN
dti-1319	100	13	to	to	ADP
dti-1319	100	14	its	its	PRON
dti-1319	100	15	target	target	NOUN
dti-1319	100	16	can	can	AUX
dti-1319	100	17	not	not	PART
dti-1319	100	18	be	be	AUX
dti-1319	100	19	any	any	ADV
dti-1319	100	20	longer	long	ADV
dti-1319	100	21	improved	improve	VERB
dti-1319	100	22	by	by	ADP
dti-1319	100	23	subsequent	subsequent	ADJ
dti-1319	100	24	selex	selex	PROPN
dti-1319	100	25	cycles	cycle	NOUN
dti-1319	100	26	,	,	PUNCT
dti-1319	100	27	this	this	DET
dti-1319	100	28	fi	fi	NOUN
dti-1319	100	29	nal	nal	ADJ
dti-1319	100	30	pool	pool	NOUN
dti-1319	100	31	is	be	AUX
dti-1319	100	32	sequenced	sequence	VERB
dti-1319	100	33	for	for	ADP
dti-1319	100	34	identifi	identifi	NOUN
dti-1319	100	35	cation	cation	NOUN
dti-1319	100	36	of	of	ADP
dti-1319	100	37	aptamers	aptamer	NOUN
dti-1319	100	38	.	.	PUNCT
dti-1319	101	1	at	at	ADP
dti-1319	101	2	this	this	DET
dti-1319	101	3	stage	stage	NOUN
dti-1319	101	4	one	one	PRON
dti-1319	101	5	expects	expect	VERB
dti-1319	101	6	that	that	SCONJ
dti-1319	101	7	similar	similar	ADJ
dti-1319	101	8	sequence	sequence	NOUN
dti-1319	101	9	motifs	motif	NOUN
dti-1319	101	10	have	have	AUX
dti-1319	101	11	been	be	AUX
dti-1319	101	12	preserved	preserve	VERB
dti-1319	101	13	in	in	ADP
dti-1319	101	14	aptamers	aptamer	NOUN
dti-1319	101	15	with	with	ADP
dti-1319	101	16	binding	bind	VERB
dti-1319	101	17	affi	affi	PROPN
dti-1319	101	18	nity	nity	NOUN
dti-1319	101	19	to	to	ADP
dti-1319	101	20	their	their	PRON
dti-1319	101	21	targets	target	NOUN
dti-1319	101	22	and	and	CCONJ
dti-1319	101	23	that	that	SCONJ
dti-1319	101	24	in	in	ADP
dti-1319	101	25	most	most	ADJ
dti-1319	101	26	cases	case	NOUN
dti-1319	101	27	these	these	DET
dti-1319	101	28	consensus	consensus	NOUN
dti-1319	101	29	sequences	sequence	NOUN
dti-1319	101	30	fall	fall	VERB
dti-1319	101	31	into	into	ADP
dti-1319	101	32	conserved	conserve	VERB
dti-1319	101	33	stem	stem	NOUN
dti-1319	101	34	-	-	PUNCT
dti-1319	101	35	loop	loop	NOUN
dti-1319	101	36	motifs	motif	NOUN
dti-1319	101	37	.	.	PUNCT
dti-1319	102	1	these	these	DET
dti-1319	102	2	rna	rna	NOUN
dti-1319	102	3	or	or	CCONJ
dti-1319	102	4	dna	dna	NOUN
dti-1319	102	5	molecules	molecule	NOUN
dti-1319	102	6	with	with	ADP
dti-1319	102	7	unique	unique	ADJ
dti-1319	102	8	binding	binding	ADJ
dti-1319	102	9	characteristics	characteristic	NOUN
dti-1319	102	10	,	,	PUNCT
dti-1319	102	11	also	also	ADV
dti-1319	102	12	denominated	denominate	VERB
dti-1319	102	13	as	as	ADP
dti-1319	102	14	aptamers	aptamer	NOUN
dti-1319	102	15	(	(	PUNCT
dti-1319	102	16	from	from	ADP
dti-1319	102	17	latin	latin	ADJ
dti-1319	102	18	aptus	aptus	NOUN
dti-1319	102	19	=	=	PUNCT
dti-1319	102	20	to	to	ADP
dti-1319	102	21	fi	fi	NOUN
dti-1319	102	22	t	t	PROPN
dti-1319	102	23	)	)	PUNCT
dti-1319	102	24	can	can	AUX
dti-1319	102	25	be	be	AUX
dti-1319	102	26	used	use	VERB
dti-1319	102	27	for	for	ADP
dti-1319	102	28	basic	basic	ADJ
dti-1319	102	29	research	research	NOUN
dti-1319	102	30	,	,	PUNCT
dti-1319	102	31	clinical	clinical	ADJ
dti-1319	102	32	and	and	CCONJ
dti-1319	102	33	diagnostic	diagnostic	ADJ
dti-1319	102	34	purposes	purpose	NOUN
dti-1319	102	35	.	.	PUNCT
dti-1319	103	1	basic	basic	ADJ
dti-1319	103	2	research	research	NOUN
dti-1319	103	3	purposes	purpose	NOUN
dti-1319	103	4	include	include	VERB
dti-1319	103	5	the	the	DET
dti-1319	103	6	characterization	characterization	NOUN
dti-1319	103	7	of	of	ADP
dti-1319	103	8	aptamer	aptamer	NOUN
dti-1319	103	9	-	-	PUNCT
dti-1319	103	10	target	target	NOUN
dti-1319	103	11	protein	protein	NOUN
dti-1319	103	12	interaction	interaction	NOUN
dti-1319	103	13	in	in	ADP
dti-1319	103	14	its	its	PRON
dti-1319	103	15	cellular	cellular	ADJ
dti-1319	103	16	context	context	NOUN
dti-1319	103	17	(	(	PUNCT
dti-1319	103	18	ulrich	ulrich	PROPN
dti-1319	103	19	et	et	PROPN
dti-1319	103	20	al	al	PROPN
dti-1319	103	21	.	.	PROPN
dti-1319	103	22	1998	1998	NUM
dti-1319	103	23	,	,	PUNCT
dti-1319	103	24	2002	2002	NUM
dti-1319	103	25	)	)	PUNCT
dti-1319	103	26	,	,	PUNCT
dti-1319	103	27	the	the	DET
dti-1319	103	28	study	study	NOUN
dti-1319	103	29	of	of	ADP
dti-1319	103	30	the	the	DET
dti-1319	103	31	mechanism	mechanism	NOUN
dti-1319	103	32	of	of	ADP
dti-1319	103	33	protein	protein	NOUN
dti-1319	103	34	activation	activation	NOUN
dti-1319	103	35	and	and	CCONJ
dti-1319	103	36	inactivation	inactivation	NOUN
dti-1319	103	37	(	(	PUNCT
dti-1319	103	38	hess	hess	NOUN
dti-1319	103	39	et	et	PROPN
dti-1319	103	40	al	al	PROPN
dti-1319	103	41	.	.	PROPN
dti-1319	103	42	2000	2000	NUM
dti-1319	103	43	)	)	PUNCT
dti-1319	103	44	,	,	PUNCT
dti-1319	103	45	the	the	DET
dti-1319	103	46	mapping	mapping	NOUN
dti-1319	103	47	of	of	ADP
dti-1319	103	48	binding	bind	VERB
dti-1319	103	49	sites	site	NOUN
dti-1319	103	50	(	(	PUNCT
dti-1319	103	51	shi	shi	PROPN
dti-1319	103	52	et	et	PROPN
dti-1319	103	53	al	al	PROPN
dti-1319	103	54	.	.	PROPN
dti-1319	103	55	2007	2007	NUM
dti-1319	103	56	)	)	PUNCT
dti-1319	103	57	,	,	PUNCT
dti-1319	103	58	the	the	DET
dti-1319	103	59	dissection	dissection	NOUN
dti-1319	103	60	of	of	ADP
dti-1319	103	61	intracellular	intracellular	ADJ
dti-1319	103	62	signaling	signal	VERB
dti-1319	103	63	pathways	pathway	NOUN
dti-1319	103	64	(	(	PUNCT
dti-1319	103	65	famulok	famulok	NOUN
dti-1319	103	66	et	et	PROPN
dti-1319	103	67	al	al	PROPN
dti-1319	103	68	.	.	PROPN
dti-1319	103	69	2001	2001	NUM
dti-1319	103	70	)	)	PUNCT
dti-1319	103	71	as	as	ADV
dti-1319	103	72	well	well	ADV
dti-1319	103	73	as	as	ADP
dti-1319	103	74	the	the	DET
dti-1319	103	75	inhibition	inhibition	NOUN
dti-1319	103	76	of	of	ADP
dti-1319	103	77	intracellular	intracellular	ADJ
dti-1319	103	78	virus	virus	NOUN
dti-1319	103	79	replication	replication	NOUN
dti-1319	103	80	(	(	PUNCT
dti-1319	103	81	toulmé	toulmé	ADV
dti-1319	103	82	et	et	PROPN
dti-1319	103	83	al	al	PROPN
dti-1319	103	84	.	.	PROPN
dti-1319	103	85	2003	2003	NUM
dti-1319	103	86	)	)	PUNCT
dti-1319	103	87	.	.	PUNCT
dti-1319	104	1	an	an	DET
dti-1319	104	2	example	example	NOUN
dti-1319	104	3	for	for	ADP
dti-1319	104	4	an	an	DET
dti-1319	104	5	intracellular	intracellular	ADJ
dti-1319	104	6	acting	act	VERB
dti-1319	104	7	aptamer	aptamer	NOUN
dti-1319	104	8	(	(	PUNCT
dti-1319	104	9	intramer	intramer	PROPN
dti-1319	104	10	)	)	PUNCT
dti-1319	104	11	is	be	AUX
dti-1319	104	12	an	an	DET
dti-1319	104	13	rna	rna	NOUN
dti-1319	104	14	molecule	molecule	NOUN
dti-1319	104	15	selected	select	VERB
dti-1319	104	16	as	as	ADP
dti-1319	104	17	highaffi	highaffi	PROPN
dti-1319	104	18	nity	nity	NOUN
dti-1319	104	19	ligand	ligand	NOUN
dti-1319	104	20	of	of	ADP
dti-1319	104	21	the	the	DET
dti-1319	104	22	b52	b52	PROPN
dti-1319	104	23	protein	protein	NOUN
dti-1319	104	24	.	.	PUNCT
dti-1319	105	1	the	the	DET
dti-1319	105	2	protein	protein	NOUN
dti-1319	105	3	b52	b52	NOUN
dti-1319	105	4	is	be	AUX
dti-1319	105	5	expressed	express	VERB
dti-1319	105	6	during	during	ADP
dti-1319	105	7	drosophila	drosophila	NOUN
dti-1319	105	8	development	development	NOUN
dti-1319	105	9	and	and	CCONJ
dti-1319	105	10	acts	act	NOUN
dti-1319	105	11	there	there	ADV
dti-1319	105	12	in	in	ADP
dti-1319	105	13	the	the	DET
dti-1319	105	14	gene	gene	NOUN
dti-1319	105	15	-	-	PUNCT
dti-1319	105	16	splicing	splicing	NOUN
dti-1319	105	17	process	process	NOUN
dti-1319	105	18	.	.	PUNCT
dti-1319	106	1	as	as	SCONJ
dti-1319	106	2	the	the	DET
dti-1319	106	3	exact	exact	ADJ
dti-1319	106	4	function	function	NOUN
dti-1319	106	5	of	of	ADP
dti-1319	106	6	this	this	DET
dti-1319	106	7	protein	protein	NOUN
dti-1319	106	8	was	be	AUX
dti-1319	106	9	not	not	PART
dti-1319	106	10	fully	fully	ADV
dti-1319	106	11	understood	understand	VERB
dti-1319	106	12	,	,	PUNCT
dti-1319	106	13	an	an	DET
dti-1319	106	14	anti	anti	ADJ
dti-1319	106	15	-	-	ADJ
dti-1319	106	16	b52	b52	ADJ
dti-1319	106	17	intramer	intramer	NOUN
dti-1319	106	18	was	be	AUX
dti-1319	106	19	developed	develop	VERB
dti-1319	106	20	and	and	CCONJ
dti-1319	106	21	expressed	express	VERB
dti-1319	106	22	as	as	ADP
dti-1319	106	23	a	a	DET
dti-1319	106	24	pentameric	pentameric	ADJ
dti-1319	106	25	structure	structure	NOUN
dti-1319	106	26	in	in	ADP
dti-1319	106	27	developing	develop	VERB
dti-1319	106	28	drosophila	drosophila	NOUN
dti-1319	106	29	cells	cell	NOUN
dti-1319	106	30	.	.	PUNCT
dti-1319	107	1	the	the	DET
dti-1319	107	2	observed	observe	VERB
dti-1319	107	3	drastic	drastic	ADJ
dti-1319	107	4	reduction	reduction	NOUN
dti-1319	107	5	of	of	ADP
dti-1319	107	6	drosophila	drosophila	NOUN
dti-1319	107	7	survival	survival	NOUN
dti-1319	107	8	in	in	ADP
dti-1319	107	9	the	the	DET
dti-1319	107	10	presence	presence	NOUN
dti-1319	107	11	of	of	ADP
dti-1319	107	12	the	the	DET
dti-1319	107	13	aptamer	aptamer	NOUN
dti-1319	107	14	indicated	indicate	VERB
dti-1319	107	15	crucial	crucial	ADJ
dti-1319	107	16	functions	function	NOUN
dti-1319	107	17	of	of	ADP
dti-1319	107	18	the	the	DET
dti-1319	107	19	b52	b52	NOUN
dti-1319	107	20	protein	protein	NOUN
dti-1319	107	21	(	(	PUNCT
dti-1319	107	22	shi	shi	PROPN
dti-1319	107	23	et	et	PROPN
dti-1319	107	24	al	al	PROPN
dti-1319	107	25	.	.	PROPN
dti-1319	107	26	1999	1999	NUM
dti-1319	107	27	)	)	PUNCT
dti-1319	107	28	.	.	PUNCT
dti-1319	108	1	another	another	DET
dti-1319	108	2	approach	approach	NOUN
dti-1319	108	3	in	in	ADP
dti-1319	108	4	therapeutics	therapeutic	NOUN
dti-1319	108	5	makes	make	VERB
dti-1319	108	6	use	use	NOUN
dti-1319	108	7	of	of	ADP
dti-1319	108	8	an	an	DET
dti-1319	108	9	aptamer	aptamer	NOUN
dti-1319	108	10	that	that	PRON
dti-1319	108	11	binds	bind	VERB
dti-1319	108	12	the	the	DET
dti-1319	108	13	intracellular	intracellular	ADJ
dti-1319	108	14	domain	domain	NOUN
dti-1319	108	15	of	of	ADP
dti-1319	108	16	the	the	DET
dti-1319	108	17	β−2	β−2	PROPN
dti-1319	108	18	integrin	integrin	NOUN
dti-1319	108	19	lymphocyte	lymphocyte	ADJ
dti-1319	108	20	function	function	NOUN
dti-1319	108	21	-	-	PUNCT
dti-1319	108	22	associated	associate	VERB
dti-1319	108	23	antigen-1	antigen-1	X
dti-1319	108	24	(	(	PUNCT
dti-1319	108	25	lfa-1	lfa-1	NUM
dti-1319	108	26	)	)	PUNCT
dti-1319	108	27	.	.	PUNCT
dti-1319	109	1	this	this	DET
dti-1319	109	2	portion	portion	NOUN
dti-1319	109	3	mediates	mediate	VERB
dti-1319	109	4	cell	cell	NOUN
dti-1319	109	5	adhesion	adhesion	NOUN
dti-1319	109	6	by	by	ADP
dti-1319	109	7	binding	bind	VERB
dti-1319	109	8	to	to	ADP
dti-1319	109	9	the	the	DET
dti-1319	109	10	intercellular	intercellular	ADJ
dti-1319	109	11	adhesion	adhesion	NOUN
dti-1319	109	12	molecule-1	molecule-1	PROPN
dti-1319	109	13	(	(	PUNCT
dti-1319	109	14	icam-1	icam-1	NOUN
dti-1319	109	15	)	)	PUNCT
dti-1319	109	16	.	.	PUNCT
dti-1319	110	1	the	the	DET
dti-1319	110	2	specifi	specifi	PROPN
dti-1319	110	3	c	c	PROPN
dti-1319	110	4	blockage	blockage	NOUN
dti-1319	110	5	of	of	ADP
dti-1319	110	6	signaling	signal	VERB
dti-1319	110	7	pathways	pathway	NOUN
dti-1319	110	8	in	in	ADP
dti-1319	110	9	vivo	vivo	NOUN
dti-1319	110	10	by	by	ADP
dti-1319	110	11	intramers	intramer	NOUN
dti-1319	110	12	could	could	AUX
dti-1319	110	13	potentially	potentially	ADV
dti-1319	110	14	be	be	AUX
dti-1319	110	15	applied	apply	VERB
dti-1319	110	16	to	to	ADP
dti-1319	110	17	any	any	DET
dti-1319	110	18	signal	signal	NOUN
dti-1319	110	19	-	-	PUNCT
dti-1319	110	20	transduction	transduction	NOUN
dti-1319	110	21	cascade	cascade	NOUN
dti-1319	110	22	(	(	PUNCT
dti-1319	110	23	blind	blind	ADJ
dti-1319	110	24	et	et	PROPN
dti-1319	110	25	al	al	PROPN
dti-1319	110	26	.	.	PROPN
dti-1319	110	27	1999	1999	NUM
dti-1319	110	28	)	)	PUNCT
dti-1319	110	29	.	.	PUNCT
dti-1319	111	1	the	the	DET
dti-1319	111	2	intramer	intramer	NOUN
dti-1319	111	3	against	against	ADP
dti-1319	111	4	the	the	DET
dti-1319	111	5	rev	rev	ADJ
dti-1319	111	6	protein	protein	NOUN
dti-1319	111	7	,	,	PUNCT
dti-1319	111	8	which	which	PRON
dti-1319	111	9	is	be	AUX
dti-1319	111	10	involved	involve	VERB
dti-1319	111	11	in	in	ADP
dti-1319	111	12	the	the	DET
dti-1319	111	13	cycle	cycle	NOUN
dti-1319	111	14	of	of	ADP
dti-1319	111	15	replication	replication	NOUN
dti-1319	111	16	of	of	ADP
dti-1319	111	17	hiv	hiv	PROPN
dti-1319	111	18	resulted	result	VERB
dti-1319	111	19	in	in	ADP
dti-1319	111	20	inhibition	inhibition	NOUN
dti-1319	111	21	of	of	ADP
dti-1319	111	22	the	the	DET
dti-1319	111	23	virus	virus	NOUN
dti-1319	111	24	replication	replication	NOUN
dti-1319	111	25	in	in	ADP
dti-1319	111	26	cell	cell	NOUN
dti-1319	111	27	culture	culture	NOUN
dti-1319	111	28	(	(	PUNCT
dti-1319	111	29	good	good	NOUN
dti-1319	111	30	et	et	PROPN
dti-1319	111	31	al	al	PROPN
dti-1319	111	32	.	.	PROPN
dti-1319	111	33	1997	1997	NUM
dti-1319	111	34	)	)	PUNCT
dti-1319	111	35	,	,	PUNCT
dti-1319	111	36	and	and	CCONJ
dti-1319	111	37	in	in	ADP
dti-1319	111	38	human	human	ADJ
dti-1319	111	39	lymphocyte	lymphocyte	ADJ
dti-1319	111	40	cells	cell	NOUN
dti-1319	111	41	(	(	PUNCT
dti-1319	111	42	chaloin	chaloin	NOUN
dti-1319	111	43	et	et	PROPN
dti-1319	111	44	al	al	PROPN
dti-1319	111	45	.	.	PROPN
dti-1319	111	46	2002	2002	NUM
dti-1319	111	47	)	)	PUNCT
dti-1319	111	48	.	.	PUNCT
dti-1319	112	1	these	these	DET
dti-1319	112	2	results	result	NOUN
dti-1319	112	3	indicate	indicate	VERB
dti-1319	112	4	that	that	SCONJ
dti-1319	112	5	intramers	intramer	NOUN
dti-1319	112	6	may	may	AUX
dti-1319	112	7	be	be	AUX
dti-1319	112	8	an	an	DET
dti-1319	112	9	alternative	alternative	NOUN
dti-1319	112	10	to	to	ADP
dti-1319	112	11	rnai	rnai	NOUN
dti-1319	112	12	by	by	ADP
dti-1319	112	13	specifi	specifi	PROPN
dti-1319	112	14	cally	cally	ADV
dti-1319	112	15	suppressing	suppress	VERB
dti-1319	112	16	the	the	DET
dti-1319	112	17	activity	activity	NOUN
dti-1319	112	18	of	of	ADP
dti-1319	112	19	gene	gene	NOUN
dti-1319	112	20	products	product	NOUN
dti-1319	112	21	instead	instead	ADV
dti-1319	112	22	of	of	ADP
dti-1319	112	23	inducing	induce	VERB
dti-1319	112	24	degradation	degradation	NOUN
dti-1319	112	25	of	of	ADP
dti-1319	112	26	mrnas	mrna	NOUN
dti-1319	112	27	coding	code	VERB
dti-1319	112	28	for	for	ADP
dti-1319	112	29	these	these	DET
dti-1319	112	30	proteins	protein	NOUN
dti-1319	112	31	.	.	PUNCT
dti-1319	113	1	the	the	DET
dti-1319	113	2	ability	ability	NOUN
dti-1319	113	3	to	to	PART
dti-1319	113	4	modulate	modulate	VERB
dti-1319	113	5	intramer	intramer	ADJ
dti-1319	113	6	activity	activity	NOUN
dti-1319	113	7	would	would	AUX
dti-1319	113	8	drastically	drastically	ADV
dti-1319	113	9	increase	increase	VERB
dti-1319	113	10	the	the	DET
dti-1319	113	11	effi	effi	PROPN
dti-1319	113	12	ciency	ciency	NOUN
dti-1319	113	13	of	of	ADP
dti-1319	113	14	regulation	regulation	NOUN
dti-1319	113	15	of	of	ADP
dti-1319	113	16	intracellular	intracellular	NOUN
dti-1319	113	17	signaling	signal	VERB
dti-1319	113	18	by	by	ADP
dti-1319	113	19	oligonucleotides	oligonucleotide	NOUN
dti-1319	113	20	.	.	PUNCT
dti-1319	114	1	the	the	DET
dti-1319	114	2	activity	activity	NOUN
dti-1319	114	3	of	of	ADP
dti-1319	114	4	these	these	DET
dti-1319	114	5	aptamers	aptamer	NOUN
dti-1319	114	6	could	could	AUX
dti-1319	114	7	be	be	AUX
dti-1319	114	8	put	put	VERB
dti-1319	114	9	under	under	ADP
dti-1319	114	10	the	the	DET
dti-1319	114	11	allosteric	allosteric	ADJ
dti-1319	114	12	control	control	NOUN
dti-1319	114	13	of	of	ADP
dti-1319	114	14	a	a	DET
dti-1319	114	15	second	second	ADJ
dti-1319	114	16	molecule	molecule	NOUN
dti-1319	114	17	(	(	PUNCT
dti-1319	114	18	tang	tang	NOUN
dti-1319	114	19	and	and	CCONJ
dti-1319	114	20	breaker	breaker	NOUN
dti-1319	114	21	,	,	PUNCT
dti-1319	114	22	1997	1997	NUM
dti-1319	114	23	)	)	PUNCT
dti-1319	114	24	or	or	CCONJ
dti-1319	114	25	their	their	PRON
dti-1319	114	26	expression	expression	NOUN
dti-1319	114	27	could	could	AUX
dti-1319	114	28	be	be	AUX
dti-1319	114	29	allosterically	allosterically	ADV
dti-1319	114	30	regulated	regulate	VERB
dti-1319	114	31	.	.	PUNCT
dti-1319	115	1	the	the	DET
dti-1319	115	2	sequence	sequence	NOUN
dti-1319	115	3	coding	code	VERB
dti-1319	115	4	for	for	ADP
dti-1319	115	5	the	the	DET
dti-1319	115	6	intramer	intramer	NOUN
dti-1319	115	7	can	can	AUX
dti-1319	115	8	be	be	AUX
dti-1319	115	9	introduced	introduce	VERB
dti-1319	115	10	in	in	ADP
dti-1319	115	11	the	the	DET
dti-1319	115	12	5′-promoter	5′-promoter	NUM
dti-1319	115	13	position	position	NOUN
dti-1319	115	14	and	and	CCONJ
dti-1319	115	15	work	work	NOUN
dti-1319	115	16	as	as	ADP
dti-1319	115	17	an	an	DET
dti-1319	115	18	inductive	inductive	ADJ
dti-1319	115	19	promoter	promoter	NOUN
dti-1319	115	20	.	.	PUNCT
dti-1319	116	1	some	some	DET
dti-1319	116	2	intramers	intramer	NOUN
dti-1319	116	3	were	be	AUX
dti-1319	116	4	developed	develop	VERB
dti-1319	116	5	against	against	ADP
dti-1319	116	6	kanamicin	kanamicin	PROPN
dti-1319	116	7	and	and	CCONJ
dti-1319	116	8	tobramicin	tobramicin	NOUN
dti-1319	116	9	and	and	CCONJ
dti-1319	116	10	expressed	express	VERB
dti-1319	116	11	in	in	ADP
dti-1319	116	12	the	the	DET
dti-1319	116	13	position	position	NOUN
dti-1319	116	14	of	of	ADP
dti-1319	116	15	the	the	DET
dti-1319	116	16	5′-gene	5′-gene	NUM
dti-1319	116	17	promoter	promoter	NOUN
dti-1319	116	18	.	.	PUNCT
dti-1319	117	1	the	the	DET
dti-1319	117	2	addition	addition	NOUN
dti-1319	117	3	of	of	ADP
dti-1319	117	4	those	those	DET
dti-1319	117	5	antibiotics	antibiotic	NOUN
dti-1319	117	6	to	to	ADP
dti-1319	117	7	the	the	DET
dti-1319	117	8	cell	cell	NOUN
dti-1319	117	9	system	system	NOUN
dti-1319	117	10	resulted	result	VERB
dti-1319	117	11	in	in	ADP
dti-1319	117	12	the	the	DET
dti-1319	117	13	shut	shut	NOUN
dti-1319	117	14	down	down	ADP
dti-1319	117	15	of	of	ADP
dti-1319	117	16	the	the	DET
dti-1319	117	17	5′-gene	5′-gene	ADJ
dti-1319	117	18	transcription	transcription	NOUN
dti-1319	117	19	(	(	PUNCT
dti-1319	117	20	werstuck	werstuck	NOUN
dti-1319	117	21	and	and	CCONJ
dti-1319	117	22	green	green	ADJ
dti-1319	117	23	,	,	PUNCT
dti-1319	117	24	1998	1998	NUM
dti-1319	117	25	)	)	PUNCT
dti-1319	117	26	.	.	PUNCT
dti-1319	118	1	the	the	DET
dti-1319	118	2	high	high	PROPN
dti-1319	118	3	specifi	specifi	PROPN
dti-1319	118	4	city	city	PROPN
dti-1319	118	5	of	of	ADP
dti-1319	118	6	aptamers	aptamer	NOUN
dti-1319	118	7	in	in	ADP
dti-1319	118	8	acting	act	VERB
dti-1319	118	9	just	just	ADV
dti-1319	118	10	on	on	ADP
dti-1319	118	11	an	an	DET
dti-1319	118	12	isotype	isotype	NOUN
dti-1319	118	13	or	or	CCONJ
dti-1319	118	14	a	a	DET
dti-1319	118	15	splice	splice	NOUN
dti-1319	118	16	-	-	PUNCT
dti-1319	118	17	variant	variant	NOUN
dti-1319	118	18	of	of	ADP
dti-1319	118	19	a	a	DET
dti-1319	118	20	target	target	NOUN
dti-1319	118	21	protein	protein	NOUN
dti-1319	118	22	makes	make	VERB
dti-1319	118	23	them	they	PRON
dti-1319	118	24	excellent	excellent	ADJ
dti-1319	118	25	drug	drug	NOUN
dti-1319	118	26	candidates	candidate	NOUN
dti-1319	118	27	.	.	PUNCT
dti-1319	119	1	in	in	ADP
dti-1319	119	2	this	this	DET
dti-1319	119	3	regard	regard	NOUN
dti-1319	119	4	,	,	PUNCT
dti-1319	119	5	theis	theis	NOUN
dti-1319	119	6	and	and	CCONJ
dti-1319	119	7	colleagues	colleague	NOUN
dti-1319	119	8	identifi	identifi	PROPN
dti-1319	119	9	ed	ed	NOUN
dti-1319	119	10	intramers	intramer	NOUN
dti-1319	119	11	which	which	PRON
dti-1319	119	12	bind	bind	VERB
dti-1319	119	13	and	and	CCONJ
dti-1319	119	14	switch	switch	VERB
dti-1319	119	15	off	off	ADP
dti-1319	119	16	the	the	DET
dti-1319	119	17	cytohesin-2	cytohesin-2	NUM
dti-1319	119	18	guanine	guanine	NOUN
dti-1319	119	19	nucleotide	nucleotide	NOUN
dti-1319	119	20	exchanger	exchanger	NOUN
dti-1319	119	21	but	but	CCONJ
dti-1319	119	22	do	do	AUX
dti-1319	119	23	not	not	PART
dti-1319	119	24	affect	affect	VERB
dti-1319	119	25	the	the	DET
dti-1319	119	26	homologous	homologous	ADJ
dti-1319	119	27	protein	protein	NOUN
dti-1319	119	28	cytohesin-1	cytohesin-1	PROPN
dti-1319	119	29	that	that	PRON
dti-1319	119	30	has	have	VERB
dti-1319	119	31	a	a	DET
dti-1319	119	32	different	different	ADJ
dti-1319	119	33	function	function	NOUN
dti-1319	119	34	.	.	PUNCT
dti-1319	120	1	this	this	DET
dti-1319	120	2	effect	effect	NOUN
dti-1319	120	3	was	be	AUX
dti-1319	120	4	observed	observe	VERB
dti-1319	120	5	following	follow	VERB
dti-1319	120	6	six	six	NUM
dti-1319	120	7	hours	hour	NOUN
dti-1319	120	8	of	of	ADP
dti-1319	120	9	hela	hela	ADJ
dti-1319	120	10	cell	cell	NOUN
dti-1319	120	11	transfection	transfection	NOUN
dti-1319	120	12	with	with	ADP
dti-1319	120	13	the	the	DET
dti-1319	120	14	aptamer	aptamer	NOUN
dti-1319	120	15	construct	construct	NOUN
dti-1319	120	16	(	(	PUNCT
dti-1319	120	17	theis	theis	PROPN
dti-1319	120	18	et	et	PROPN
dti-1319	120	19	al	al	PROPN
dti-1319	120	20	.	.	PROPN
dti-1319	120	21	2004	2004	NUM
dti-1319	120	22	)	)	PUNCT
dti-1319	120	23	.	.	PUNCT
dti-1319	121	1	these	these	DET
dti-1319	121	2	properties	property	NOUN
dti-1319	121	3	of	of	ADP
dti-1319	121	4	intramers	intramer	NOUN
dti-1319	121	5	make	make	VERB
dti-1319	121	6	them	they	PRON
dti-1319	121	7	promising	promise	VERB
dti-1319	121	8	tools	tool	NOUN
dti-1319	121	9	for	for	ADP
dti-1319	121	10	development	development	NOUN
dti-1319	121	11	of	of	ADP
dti-1319	121	12	therapeutics	therapeutic	NOUN
dti-1319	121	13	with	with	ADP
dti-1319	121	14	applications	application	NOUN
dti-1319	121	15	in	in	ADP
dti-1319	121	16	vaccine	vaccine	NOUN
dti-1319	121	17	development	development	NOUN
dti-1319	121	18	,	,	PUNCT
dti-1319	121	19	blockage	blockage	NOUN
dti-1319	121	20	of	of	ADP
dti-1319	121	21	intracellular	intracellular	ADJ
dti-1319	121	22	transduction	transduction	NOUN
dti-1319	121	23	pathways	pathway	NOUN
dti-1319	121	24	,	,	PUNCT
dti-1319	121	25	in	in	ADP
dti-1319	121	26	viral	viral	ADJ
dti-1319	121	27	infection	infection	NOUN
dti-1319	121	28	control	control	NOUN
dti-1319	121	29	and	and	CCONJ
dti-1319	121	30	timedependent	timedependent	NOUN
dti-1319	121	31	gene	gene	NOUN
dti-1319	121	32	knockdown	knockdown	NOUN
dti-1319	121	33	of	of	ADP
dti-1319	121	34	protein	protein	NOUN
dti-1319	121	35	activity	activity	NOUN
dti-1319	121	36	.	.	PUNCT
dti-1319	122	1	the	the	DET
dti-1319	122	2	suppression	suppression	NOUN
dti-1319	122	3	of	of	ADP
dti-1319	122	4	target	target	NOUN
dti-1319	122	5	protein	protein	NOUN
dti-1319	122	6	activity	activity	NOUN
dti-1319	122	7	at	at	ADP
dti-1319	122	8	desired	desire	VERB
dti-1319	122	9	time	time	NOUN
dti-1319	122	10	points	point	NOUN
dti-1319	122	11	followed	follow	VERB
dti-1319	122	12	by	by	ADP
dti-1319	122	13	aptamer	aptamer	NOUN
dti-1319	122	14	inactivation	inactivation	NOUN
dti-1319	122	15	may	may	AUX
dti-1319	122	16	gain	gain	VERB
dti-1319	122	17	importance	importance	NOUN
dti-1319	122	18	in	in	ADP
dti-1319	122	19	the	the	DET
dti-1319	122	20	control	control	NOUN
dti-1319	122	21	of	of	ADP
dti-1319	122	22	important	important	ADJ
dti-1319	122	23	188	188	NUM
dti-1319	122	24	ulrich	ulrich	PROPN
dti-1319	122	25	et	et	PROPN
dti-1319	122	26	al	al	PROPN
dti-1319	122	27	drug	drug	PROPN
dti-1319	122	28	target	target	NOUN
dti-1319	122	29	insights	insight	VERB
dti-1319	122	30	2007:2	2007:2	NUM
dti-1319	122	31	physiological	physiological	ADJ
dti-1319	122	32	functions	function	NOUN
dti-1319	122	33	such	such	ADJ
dti-1319	122	34	as	as	ADP
dti-1319	122	35	blood	blood	NOUN
dti-1319	122	36	coagulation	coagulation	NOUN
dti-1319	122	37	(	(	PUNCT
dti-1319	122	38	rusconi	rusconi	PROPN
dti-1319	122	39	et	et	PROPN
dti-1319	122	40	al	al	PROPN
dti-1319	122	41	.	.	PROPN
dti-1319	122	42	2004	2004	NUM
dti-1319	122	43	)	)	PUNCT
dti-1319	122	44	.	.	PUNCT
dti-1319	123	1	inhibition	inhibition	NOUN
dti-1319	123	2	of	of	ADP
dti-1319	123	3	coagulation	coagulation	NOUN
dti-1319	123	4	is	be	AUX
dti-1319	123	5	for	for	ADP
dti-1319	123	6	instance	instance	NOUN
dti-1319	123	7	desirable	desirable	ADJ
dti-1319	123	8	in	in	ADP
dti-1319	123	9	a	a	DET
dti-1319	123	10	pathological	pathological	ADJ
dti-1319	123	11	condition	condition	NOUN
dti-1319	123	12	of	of	ADP
dti-1319	123	13	high	high	ADJ
dti-1319	123	14	blood	blood	NOUN
dti-1319	123	15	pressure	pressure	NOUN
dti-1319	123	16	,	,	PUNCT
dti-1319	123	17	but	but	CCONJ
dti-1319	123	18	must	must	AUX
dti-1319	123	19	be	be	AUX
dti-1319	123	20	immediately	immediately	ADV
dti-1319	123	21	reversed	reverse	VERB
dti-1319	123	22	in	in	ADP
dti-1319	123	23	case	case	NOUN
dti-1319	123	24	of	of	ADP
dti-1319	123	25	hemorrhage	hemorrhage	NOUN
dti-1319	123	26	.	.	PUNCT
dti-1319	124	1	moreover	moreover	ADV
dti-1319	124	2	,	,	PUNCT
dti-1319	124	3	aptamers	aptamer	NOUN
dti-1319	124	4	are	be	AUX
dti-1319	124	5	very	very	ADV
dti-1319	124	6	potent	potent	ADJ
dti-1319	124	7	inhibitors	inhibitor	NOUN
dti-1319	124	8	of	of	ADP
dti-1319	124	9	extracellular	extracellular	ADJ
dti-1319	124	10	protein	protein	NOUN
dti-1319	124	11	activity	activity	NOUN
dti-1319	124	12	,	,	PUNCT
dti-1319	124	13	for	for	ADP
dti-1319	124	14	instance	instance	NOUN
dti-1319	124	15	by	by	ADP
dti-1319	124	16	blocking	block	VERB
dti-1319	124	17	growth	growth	NOUN
dti-1319	124	18	factor	factor	NOUN
dti-1319	124	19	-	-	PUNCT
dti-1319	124	20	receptor	receptor	NOUN
dti-1319	124	21	binding	binding	NOUN
dti-1319	124	22	.	.	PUNCT
dti-1319	125	1	an	an	DET
dti-1319	125	2	anti	anti	ADJ
dti-1319	125	3	-	-	ADJ
dti-1319	125	4	vegf165	vegf165	ADJ
dti-1319	125	5	aptamer	aptamer	NOUN
dti-1319	125	6	was	be	AUX
dti-1319	125	7	developed	develop	VERB
dti-1319	125	8	that	that	PRON
dti-1319	125	9	blocks	block	VERB
dti-1319	125	10	pathological	pathological	ADJ
dti-1319	125	11	vegf165	vegf165	PROPN
dti-1319	125	12	-	-	PUNCT
dti-1319	125	13	receptor	receptor	NOUN
dti-1319	125	14	binding	binding	NOUN
dti-1319	125	15	,	,	PUNCT
dti-1319	125	16	thereby	thereby	ADV
dti-1319	125	17	leaving	leave	VERB
dti-1319	125	18	other	other	ADJ
dti-1319	125	19	vital	vital	ADJ
dti-1319	125	20	vegf	vegf	NOUN
dti-1319	125	21	isoform	isoform	NOUN
dti-1319	125	22	action	action	NOUN
dti-1319	125	23	unaffected	unaffected	ADJ
dti-1319	125	24	.	.	PUNCT
dti-1319	126	1	an	an	DET
dti-1319	126	2	antivegf165	antivegf165	PROPN
dti-1319	126	3	aptamer	aptamer	NOUN
dti-1319	126	4	formulation	formulation	NOUN
dti-1319	126	5	has	have	AUX
dti-1319	126	6	been	be	AUX
dti-1319	126	7	recently	recently	ADV
dti-1319	126	8	approved	approve	VERB
dti-1319	126	9	for	for	ADP
dti-1319	126	10	therapeutic	therapeutic	ADJ
dti-1319	126	11	use	use	NOUN
dti-1319	126	12	by	by	ADP
dti-1319	126	13	the	the	DET
dti-1319	126	14	fda	fda	PROPN
dti-1319	126	15	and	and	CCONJ
dti-1319	126	16	trade	trade	NOUN
dti-1319	126	17	-	-	PUNCT
dti-1319	126	18	named	name	VERB
dti-1319	126	19	as	as	ADP
dti-1319	126	20	macugen	macugen	PROPN
dti-1319	126	21	(	(	PUNCT
dti-1319	126	22	reviewed	review	VERB
dti-1319	126	23	by	by	ADP
dti-1319	126	24	ulrich	ulrich	PROPN
dti-1319	126	25	et	et	PROPN
dti-1319	126	26	al	al	PROPN
dti-1319	126	27	.	.	PROPN
dti-1319	126	28	2006	2006	NUM
dti-1319	126	29	;	;	PUNCT
dti-1319	126	30	vavvas	vavvas	NOUN
dti-1319	126	31	and	and	CCONJ
dti-1319	126	32	d’amico	d’amico	PROPN
dti-1319	126	33	,	,	PUNCT
dti-1319	126	34	2006	2006	NUM
dti-1319	126	35	;	;	PUNCT
dti-1319	126	36	ng	ng	PROPN
dti-1319	126	37	et	et	PROPN
dti-1319	126	38	al	al	PROPN
dti-1319	126	39	.	.	PROPN
dti-1319	126	40	2006	2006	NUM
dti-1319	126	41	)	)	PUNCT
dti-1319	126	42	.	.	PUNCT
dti-1319	127	1	another	another	DET
dti-1319	127	2	promising	promising	ADJ
dti-1319	127	3	aptamer	aptamer	NOUN
dti-1319	127	4	tested	test	VERB
dti-1319	127	5	in	in	ADP
dti-1319	127	6	clinical	clinical	ADJ
dti-1319	127	7	trials	trial	NOUN
dti-1319	127	8	has	have	AUX
dti-1319	127	9	been	be	AUX
dti-1319	127	10	denominated	denominate	VERB
dti-1319	127	11	reg1	reg1	NOUN
dti-1319	127	12	(	(	PUNCT
dti-1319	127	13	regado	regado	NOUN
dti-1319	127	14	biosciences	bioscience	NOUN
dti-1319	127	15	)	)	PUNCT
dti-1319	127	16	.	.	PUNCT
dti-1319	128	1	this	this	DET
dti-1319	128	2	therapeutic	therapeutic	ADJ
dti-1319	128	3	aptamer	aptamer	NOUN
dti-1319	128	4	targets	target	NOUN
dti-1319	128	5	factor	factor	NOUN
dti-1319	128	6	ixa	ixa	NOUN
dti-1319	128	7	(	(	PUNCT
dti-1319	128	8	drug	drug	NOUN
dti-1319	128	9	,	,	PUNCT
dti-1319	128	10	rb006	rb006	NOUN
dti-1319	128	11	)	)	PUNCT
dti-1319	128	12	with	with	ADP
dti-1319	128	13	anti	anti	ADJ
dti-1319	128	14	-	-	ADJ
dti-1319	128	15	coagulation	coagulation	ADJ
dti-1319	128	16	activity	activity	NOUN
dti-1319	128	17	.	.	PUNCT
dti-1319	129	1	the	the	DET
dti-1319	129	2	aptamer	aptamer	NOUN
dti-1319	129	3	and	and	CCONJ
dti-1319	129	4	its	its	PRON
dti-1319	129	5	complementary	complementary	ADJ
dti-1319	129	6	oligonucleotide	oligonucleotide	NOUN
dti-1319	129	7	antidote	antidote	NOUN
dti-1319	129	8	(	(	PUNCT
dti-1319	129	9	rb007	rb007	PROPN
dti-1319	129	10	)	)	PUNCT
dti-1319	129	11	were	be	AUX
dti-1319	129	12	tested	test	VERB
dti-1319	129	13	in	in	ADP
dti-1319	129	14	healthy	healthy	ADJ
dti-1319	129	15	volunteers	volunteer	NOUN
dti-1319	129	16	in	in	ADP
dti-1319	129	17	a	a	DET
dti-1319	129	18	phase	phase	NOUN
dti-1319	129	19	1a	1a	X
dti-1319	129	20	pharmacodynamic	pharmacodynamic	ADJ
dti-1319	129	21	evaluation	evaluation	NOUN
dti-1319	129	22	(	(	PUNCT
dti-1319	129	23	dyke	dyke	NOUN
dti-1319	129	24	et	et	PROPN
dti-1319	129	25	al	al	PROPN
dti-1319	129	26	.	.	PROPN
dti-1319	129	27	2006	2006	NUM
dti-1319	129	28	)	)	PUNCT
dti-1319	129	29	.	.	PUNCT
dti-1319	130	1	there	there	PRON
dti-1319	130	2	was	be	VERB
dti-1319	130	3	not	not	PART
dti-1319	130	4	any	any	DET
dti-1319	130	5	signifi	signifi	NOUN
dti-1319	130	6	ca	can	AUX
dti-1319	130	7	nt	not	PART
dti-1319	130	8	bleeding	bleed	VERB
dti-1319	130	9	occurrence	occurrence	NOUN
dti-1319	130	10	associated	associate	VERB
dti-1319	130	11	with	with	ADP
dti-1319	130	12	rb006	rb006	ADJ
dti-1319	130	13	treatment	treatment	NOUN
dti-1319	130	14	,	,	PUNCT
dti-1319	130	15	and	and	CCONJ
dti-1319	130	16	both	both	DET
dti-1319	130	17	aptamer	aptamer	NOUN
dti-1319	130	18	drug	drug	NOUN
dti-1319	130	19	and	and	CCONJ
dti-1319	130	20	antidote	antidote	NOUN
dti-1319	130	21	were	be	AUX
dti-1319	130	22	well	well	ADV
dti-1319	130	23	tolerated	tolerate	VERB
dti-1319	130	24	.	.	PUNCT
dti-1319	131	1	the	the	DET
dti-1319	131	2	overall	overall	ADJ
dti-1319	131	3	results	result	NOUN
dti-1319	131	4	of	of	ADP
dti-1319	131	5	the	the	DET
dti-1319	131	6	pharmacokinetics	pharmacokinetic	NOUN
dti-1319	131	7	of	of	ADP
dti-1319	131	8	the	the	DET
dti-1319	131	9	two	two	NUM
dti-1319	131	10	compounds	compound	NOUN
dti-1319	131	11	in	in	ADP
dti-1319	131	12	healthy	healthy	ADJ
dti-1319	131	13	volunteers	volunteer	NOUN
dti-1319	131	14	indicated	indicate	VERB
dti-1319	131	15	their	their	PRON
dti-1319	131	16	safe	safe	ADJ
dti-1319	131	17	use	use	NOUN
dti-1319	131	18	in	in	ADP
dti-1319	131	19	humans	human	NOUN
dti-1319	131	20	encouraging	encourage	VERB
dti-1319	131	21	further	further	ADJ
dti-1319	131	22	studies	study	NOUN
dti-1319	131	23	(	(	PUNCT
dti-1319	131	24	dyke	dyke	PROPN
dti-1319	131	25	et	et	PROPN
dti-1319	131	26	al	al	PROPN
dti-1319	131	27	.	.	PROPN
dti-1319	131	28	2006	2006	NUM
dti-1319	131	29	)	)	PUNCT
dti-1319	131	30	.	.	PUNCT
dti-1319	132	1	in	in	ADP
dti-1319	132	2	addition	addition	NOUN
dti-1319	132	3	to	to	ADP
dti-1319	132	4	their	their	PRON
dti-1319	132	5	possible	possible	ADJ
dti-1319	132	6	therapeutic	therapeutic	ADJ
dti-1319	132	7	relevance	relevance	NOUN
dti-1319	132	8	,	,	PUNCT
dti-1319	132	9	aptamers	aptamer	NOUN
dti-1319	132	10	may	may	AUX
dti-1319	132	11	be	be	AUX
dti-1319	132	12	used	use	VERB
dti-1319	132	13	in	in	ADP
dti-1319	132	14	diagnostic	diagnostic	ADJ
dti-1319	132	15	applications	application	NOUN
dti-1319	132	16	,	,	PUNCT
dti-1319	132	17	such	such	ADJ
dti-1319	132	18	as	as	ADP
dti-1319	132	19	differentiating	differentiate	VERB
dti-1319	132	20	between	between	ADP
dti-1319	132	21	normal	normal	ADJ
dti-1319	132	22	and	and	CCONJ
dti-1319	132	23	tumoral	tumoral	ADJ
dti-1319	132	24	vasculature	vasculature	NOUN
dti-1319	132	25	(	(	PUNCT
dti-1319	132	26	blank	blank	NOUN
dti-1319	132	27	et	et	PROPN
dti-1319	132	28	al	al	PROPN
dti-1319	132	29	.	.	PROPN
dti-1319	132	30	2001	2001	NUM
dti-1319	132	31	)	)	PUNCT
dti-1319	132	32	,	,	PUNCT
dti-1319	132	33	the	the	DET
dti-1319	132	34	pathogenic	pathogenic	ADJ
dti-1319	132	35	form	form	NOUN
dti-1319	132	36	of	of	ADP
dti-1319	132	37	the	the	DET
dti-1319	132	38	prion	prion	NOUN
dti-1319	132	39	protein	protein	NOUN
dti-1319	132	40	from	from	ADP
dti-1319	132	41	its	its	PRON
dti-1319	132	42	normal	normal	ADJ
dti-1319	132	43	conformation	conformation	NOUN
dti-1319	132	44	(	(	PUNCT
dti-1319	132	45	rhie	rhie	NOUN
dti-1319	132	46	et	et	PROPN
dti-1319	132	47	al	al	PROPN
dti-1319	132	48	.	.	PROPN
dti-1319	132	49	2003	2003	NUM
dti-1319	132	50	)	)	PUNCT
dti-1319	132	51	,	,	PUNCT
dti-1319	132	52	as	as	ADV
dti-1319	132	53	well	well	ADV
dti-1319	132	54	as	as	ADP
dti-1319	132	55	identifying	identify	VERB
dti-1319	132	56	possible	possible	ADJ
dti-1319	132	57	biohazards	biohazard	NOUN
dti-1319	132	58	,	,	PUNCT
dti-1319	132	59	such	such	ADJ
dti-1319	132	60	as	as	ADP
dti-1319	132	61	anthrax	anthrax	NOUN
dti-1319	132	62	spores	spore	NOUN
dti-1319	132	63	(	(	PUNCT
dti-1319	132	64	bruno	bruno	PROPN
dti-1319	132	65	and	and	CCONJ
dti-1319	132	66	kiel	kiel	PROPN
dti-1319	132	67	,	,	PUNCT
dti-1319	132	68	1999	1999	NUM
dti-1319	132	69	)	)	PUNCT
dti-1319	132	70	.	.	PUNCT
dti-1319	133	1	the	the	DET
dti-1319	133	2	possible	possible	ADJ
dti-1319	133	3	pharmaceutical	pharmaceutical	ADJ
dti-1319	133	4	and	and	CCONJ
dti-1319	133	5	therapeutic	therapeutic	ADJ
dti-1319	133	6	importance	importance	NOUN
dti-1319	133	7	of	of	ADP
dti-1319	133	8	aptamers	aptamer	NOUN
dti-1319	133	9	is	be	AUX
dti-1319	133	10	mainly	mainly	ADV
dti-1319	133	11	related	relate	VERB
dti-1319	133	12	to	to	ADP
dti-1319	133	13	the	the	DET
dti-1319	133	14	following	following	ADJ
dti-1319	133	15	characteristics	characteristic	NOUN
dti-1319	133	16	:	:	PUNCT
dti-1319	133	17	(	(	PUNCT
dti-1319	133	18	i	i	NOUN
dti-1319	133	19	)	)	PUNCT
dti-1319	133	20	their	their	PRON
dti-1319	133	21	affi	affi	ADJ
dti-1319	133	22	nity	nity	NOUN
dti-1319	133	23	for	for	ADP
dti-1319	133	24	their	their	PRON
dti-1319	133	25	targets	target	NOUN
dti-1319	133	26	with	with	ADP
dti-1319	133	27	dissociation	dissociation	NOUN
dti-1319	133	28	constants	constant	NOUN
dti-1319	133	29	in	in	ADP
dti-1319	133	30	the	the	DET
dti-1319	133	31	nanoto	nanoto	ADJ
dti-1319	133	32	picomolar	picomolar	ADJ
dti-1319	133	33	range	range	NOUN
dti-1319	133	34	,	,	PUNCT
dti-1319	133	35	similar	similar	ADJ
dti-1319	133	36	to	to	ADP
dti-1319	133	37	those	those	PRON
dti-1319	133	38	found	find	VERB
dti-1319	133	39	on	on	ADP
dti-1319	133	40	monoclonal	monoclonal	NOUN
dti-1319	133	41	antibody	antibody	NOUN
dti-1319	133	42	-	-	PUNCT
dti-1319	133	43	antigen	antigen	NOUN
dti-1319	133	44	complexes	complex	NOUN
dti-1319	133	45	.	.	PUNCT
dti-1319	134	1	high	high	ADJ
dti-1319	134	2	-	-	PUNCT
dti-1319	134	3	affi	affi	PROPN
dti-1319	134	4	nity	nity	NOUN
dti-1319	134	5	aptamer	aptamer	NOUN
dti-1319	134	6	-	-	PUNCT
dti-1319	134	7	protein	protein	NOUN
dti-1319	134	8	interactions	interaction	NOUN
dti-1319	134	9	result	result	VERB
dti-1319	134	10	from	from	ADP
dti-1319	134	11	specifi	specifi	PROPN
dti-1319	134	12	c	c	PROPN
dti-1319	134	13	hydrogen	hydrogen	NOUN
dti-1319	134	14	-	-	PUNCT
dti-1319	134	15	bond	bond	NOUN
dti-1319	134	16	formation	formation	NOUN
dti-1319	134	17	between	between	ADP
dti-1319	134	18	bases	basis	NOUN
dti-1319	134	19	and	and	CCONJ
dti-1319	134	20	amino	amino	ADJ
dti-1319	134	21	acids	acid	NOUN
dti-1319	134	22	of	of	ADP
dti-1319	134	23	the	the	DET
dti-1319	134	24	target	target	NOUN
dti-1319	134	25	proteins	protein	NOUN
dti-1319	134	26	in	in	ADP
dti-1319	134	27	addition	addition	NOUN
dti-1319	134	28	to	to	ADP
dti-1319	134	29	interactions	interaction	NOUN
dti-1319	134	30	between	between	ADP
dti-1319	134	31	oligonucleotide	oligonucleotide	NOUN
dti-1319	134	32	backbones	backbone	NOUN
dti-1319	134	33	and	and	CCONJ
dti-1319	134	34	protein	protein	NOUN
dti-1319	134	35	secondary	secondary	ADJ
dti-1319	134	36	and	and	CCONJ
dti-1319	134	37	tertiary	tertiary	ADJ
dti-1319	134	38	structures	structure	NOUN
dti-1319	134	39	.	.	PUNCT
dti-1319	135	1	(	(	PUNCT
dti-1319	135	2	ii	ii	NOUN
dti-1319	135	3	)	)	PUNCT
dti-1319	135	4	aptamers	aptamer	NOUN
dti-1319	135	5	can	can	AUX
dti-1319	135	6	be	be	AUX
dti-1319	135	7	chemically	chemically	ADV
dti-1319	135	8	modified	modify	VERB
dti-1319	135	9	to	to	PART
dti-1319	135	10	acquire	acquire	VERB
dti-1319	135	11	more	more	ADJ
dti-1319	135	12	stability	stability	NOUN
dti-1319	135	13	for	for	ADP
dti-1319	135	14	in	in	ADP
dti-1319	135	15	vivo	vivo	ADJ
dti-1319	135	16	applicatons	applicaton	NOUN
dti-1319	135	17	,	,	PUNCT
dti-1319	135	18	resulting	result	VERB
dti-1319	135	19	in	in	ADP
dti-1319	135	20	an	an	DET
dti-1319	135	21	increase	increase	NOUN
dti-1319	135	22	of	of	ADP
dti-1319	135	23	their	their	PRON
dti-1319	135	24	halflife	halflife	NOUN
dti-1319	135	25	time	time	NOUN
dti-1319	135	26	from	from	ADP
dti-1319	135	27	a	a	DET
dti-1319	135	28	couple	couple	NOUN
dti-1319	135	29	of	of	ADP
dti-1319	135	30	seconds	second	NOUN
dti-1319	135	31	to	to	ADP
dti-1319	135	32	days	day	NOUN
dti-1319	135	33	(	(	PUNCT
dti-1319	135	34	ulrich	ulrich	PROPN
dti-1319	135	35	et	et	PROPN
dti-1319	135	36	al	al	PROPN
dti-1319	135	37	.	.	PROPN
dti-1319	135	38	2004	2004	NUM
dti-1319	135	39	)	)	PUNCT
dti-1319	135	40	.	.	PUNCT
dti-1319	136	1	these	these	DET
dti-1319	136	2	modifi	modifi	NOUN
dti-1319	136	3	cations	cation	NOUN
dti-1319	136	4	in	in	ADP
dti-1319	136	5	oligonucleotide	oligonucleotide	NOUN
dti-1319	136	6	structure	structure	NOUN
dti-1319	136	7	can	can	AUX
dti-1319	136	8	be	be	AUX
dti-1319	136	9	done	do	VERB
dti-1319	136	10	prior	prior	ADV
dti-1319	136	11	or	or	CCONJ
dti-1319	136	12	following	follow	VERB
dti-1319	136	13	the	the	DET
dti-1319	136	14	selex	selex	PROPN
dti-1319	136	15	process	process	NOUN
dti-1319	136	16	.	.	PUNCT
dti-1319	137	1	(	(	PUNCT
dti-1319	137	2	iii	iii	X
dti-1319	137	3	)	)	PUNCT
dti-1319	137	4	identifi	identifi	PROPN
dti-1319	137	5	ed	ed	PROPN
dti-1319	137	6	aptamer	aptamer	PROPN
dti-1319	137	7	sequences	sequence	NOUN
dti-1319	137	8	can	can	AUX
dti-1319	137	9	be	be	AUX
dti-1319	137	10	truncated	truncate	VERB
dti-1319	137	11	to	to	ADP
dti-1319	137	12	their	their	PRON
dti-1319	137	13	minimal	minimal	ADJ
dti-1319	137	14	sequences	sequence	NOUN
dti-1319	137	15	,	,	PUNCT
dti-1319	137	16	represented	represent	VERB
dti-1319	137	17	by	by	ADP
dti-1319	137	18	a	a	DET
dti-1319	137	19	single	single	ADJ
dti-1319	137	20	loop	loop	NOUN
dti-1319	137	21	structure	structure	NOUN
dti-1319	137	22	which	which	PRON
dti-1319	137	23	is	be	AUX
dti-1319	137	24	suffi	suffi	NOUN
dti-1319	137	25	cient	cient	NOUN
dti-1319	137	26	for	for	ADP
dti-1319	137	27	binding	binding	ADJ
dti-1319	137	28	and	and	CCONJ
dti-1319	137	29	biological	biological	ADJ
dti-1319	137	30	activity	activity	NOUN
dti-1319	137	31	.	.	PUNCT
dti-1319	138	1	(	(	PUNCT
dti-1319	138	2	iv	iv	X
dti-1319	138	3	)	)	PUNCT
dti-1319	138	4	aptamers	aptamer	NOUN
dti-1319	138	5	can	can	AUX
dti-1319	138	6	be	be	AUX
dti-1319	138	7	easily	easily	ADV
dti-1319	138	8	enzymatically	enzymatically	ADV
dti-1319	138	9	reproduced	reproduce	VERB
dti-1319	138	10	or	or	CCONJ
dti-1319	138	11	produced	produce	VERB
dti-1319	138	12	in	in	ADP
dti-1319	138	13	a	a	DET
dti-1319	138	14	large	large	ADJ
dti-1319	138	15	scale	scale	NOUN
dti-1319	138	16	by	by	ADP
dti-1319	138	17	chemical	chemical	ADJ
dti-1319	138	18	synthesis	synthesis	NOUN
dti-1319	138	19	(	(	PUNCT
dti-1319	138	20	reviewed	review	VERB
dti-1319	138	21	by	by	ADP
dti-1319	138	22	ulrich	ulrich	PROPN
dti-1319	138	23	et	et	PROPN
dti-1319	138	24	al	al	PROPN
dti-1319	138	25	.	.	PROPN
dti-1319	138	26	2006	2006	NUM
dti-1319	138	27	)	)	PUNCT
dti-1319	138	28	.	.	PUNCT
dti-1319	139	1	vehicles	vehicle	NOUN
dti-1319	139	2	for	for	ADP
dti-1319	139	3	oligonucleotide	oligonucleotide	ADJ
dti-1319	139	4	delivery	delivery	NOUN
dti-1319	139	5	the	the	DET
dti-1319	139	6	combination	combination	NOUN
dti-1319	139	7	of	of	ADP
dti-1319	139	8	target	target	NOUN
dti-1319	139	9	-	-	PUNCT
dti-1319	139	10	specifi	specifi	NOUN
dti-1319	139	11	c	c	PROPN
dti-1319	139	12	drug	drug	NOUN
dti-1319	139	13	delivery	delivery	NOUN
dti-1319	139	14	and	and	CCONJ
dti-1319	139	15	its	its	PRON
dti-1319	139	16	controlled	control	VERB
dti-1319	139	17	release	release	NOUN
dti-1319	139	18	(	(	PUNCT
dti-1319	139	19	langer	langer	NOUN
dti-1319	139	20	,	,	PUNCT
dti-1319	139	21	1998	1998	NUM
dti-1319	139	22	)	)	PUNCT
dti-1319	139	23	is	be	AUX
dti-1319	139	24	an	an	DET
dti-1319	139	25	important	important	ADJ
dti-1319	139	26	goal	goal	NOUN
dti-1319	139	27	in	in	ADP
dti-1319	139	28	the	the	DET
dti-1319	139	29	search	search	NOUN
dti-1319	139	30	for	for	ADP
dti-1319	139	31	more	more	ADJ
dti-1319	139	32	effi	effi	PROPN
dti-1319	139	33	cient	cient	NOUN
dti-1319	139	34	and	and	CCONJ
dti-1319	139	35	less	less	ADV
dti-1319	139	36	hazardous	hazardous	ADJ
dti-1319	139	37	treatment	treatment	NOUN
dti-1319	139	38	of	of	ADP
dti-1319	139	39	tumoral	tumoral	ADJ
dti-1319	139	40	diseases	disease	NOUN
dti-1319	139	41	.	.	PUNCT
dti-1319	140	1	it	it	PRON
dti-1319	140	2	is	be	AUX
dti-1319	140	3	desirable	desirable	ADJ
dti-1319	140	4	that	that	SCONJ
dti-1319	140	5	the	the	DET
dti-1319	140	6	cytotoxic	cytotoxic	ADJ
dti-1319	140	7	drug	drug	NOUN
dti-1319	140	8	dosage	dosage	NOUN
dti-1319	140	9	is	be	AUX
dti-1319	140	10	delivered	deliver	VERB
dti-1319	140	11	to	to	PART
dti-1319	140	12	target	target	VERB
dti-1319	140	13	cells	cell	NOUN
dti-1319	140	14	for	for	ADP
dti-1319	140	15	a	a	DET
dti-1319	140	16	long	long	ADJ
dti-1319	140	17	time	time	NOUN
dti-1319	140	18	span	span	NOUN
dti-1319	140	19	,	,	PUNCT
dti-1319	140	20	thereby	thereby	ADV
dti-1319	140	21	sparing	spare	VERB
dti-1319	140	22	the	the	DET
dti-1319	140	23	healthy	healthy	ADJ
dti-1319	140	24	cells	cell	NOUN
dti-1319	140	25	of	of	ADP
dti-1319	140	26	the	the	DET
dti-1319	140	27	surrounding	surround	VERB
dti-1319	140	28	tissue	tissue	NOUN
dti-1319	140	29	.	.	PUNCT
dti-1319	141	1	in	in	ADP
dti-1319	141	2	order	order	NOUN
dti-1319	141	3	to	to	PART
dti-1319	141	4	attain	attain	VERB
dti-1319	141	5	this	this	DET
dti-1319	141	6	objective	objective	NOUN
dti-1319	141	7	,	,	PUNCT
dti-1319	141	8	it	it	PRON
dti-1319	141	9	is	be	AUX
dti-1319	141	10	critical	critical	ADJ
dti-1319	141	11	to	to	PART
dti-1319	141	12	develop	develop	VERB
dti-1319	141	13	specialized	specialized	ADJ
dti-1319	141	14	vessels	vessel	NOUN
dti-1319	141	15	which	which	PRON
dti-1319	141	16	encapsulate	encapsulate	VERB
dti-1319	141	17	the	the	DET
dti-1319	141	18	chemotherapeutical	chemotherapeutical	ADJ
dti-1319	141	19	drugs	drug	NOUN
dti-1319	141	20	for	for	ADP
dti-1319	141	21	its	its	PRON
dti-1319	141	22	controlled	control	VERB
dti-1319	141	23	release	release	NOUN
dti-1319	141	24	and	and	CCONJ
dti-1319	141	25	that	that	SCONJ
dti-1319	141	26	such	such	ADJ
dti-1319	141	27	vessels	vessel	NOUN
dti-1319	141	28	are	be	AUX
dti-1319	141	29	directed	direct	VERB
dti-1319	141	30	to	to	ADP
dti-1319	141	31	cancer	cancer	NOUN
dti-1319	141	32	cells	cell	NOUN
dti-1319	141	33	(	(	PUNCT
dti-1319	141	34	i.e.	i.e.	X
dti-1319	141	35	by	by	ADP
dti-1319	141	36	presenting	present	VERB
dti-1319	141	37	appropriate	appropriate	ADJ
dti-1319	141	38	ligands	ligand	NOUN
dti-1319	141	39	which	which	PRON
dti-1319	141	40	recognize	recognize	VERB
dti-1319	141	41	specifi	specifi	PROPN
dti-1319	141	42	c	c	PROPN
dti-1319	141	43	cancer	cancer	NOUN
dti-1319	141	44	-	-	PUNCT
dti-1319	141	45	cell	cell	NOUN
dti-1319	141	46	antigens	antigen	NOUN
dti-1319	141	47	)	)	PUNCT
dti-1319	141	48	.	.	PUNCT
dti-1319	142	1	a	a	DET
dti-1319	142	2	wide	wide	ADJ
dti-1319	142	3	variety	variety	NOUN
dti-1319	142	4	of	of	ADP
dti-1319	142	5	address	address	NOUN
dti-1319	142	6	-	-	PUNCT
dti-1319	142	7	molecules	molecule	NOUN
dti-1319	142	8	have	have	AUX
dti-1319	142	9	been	be	AUX
dti-1319	142	10	investigated	investigate	VERB
dti-1319	142	11	for	for	ADP
dti-1319	142	12	their	their	PRON
dti-1319	142	13	effi	effi	PROPN
dti-1319	142	14	ciency	ciency	NOUN
dti-1319	142	15	to	to	PART
dti-1319	142	16	deliver	deliver	VERB
dti-1319	142	17	oligonucleotides	oligonucleotide	NOUN
dti-1319	142	18	to	to	ADP
dti-1319	142	19	cancer	cancer	NOUN
dti-1319	142	20	cells	cell	NOUN
dti-1319	142	21	.	.	PUNCT
dti-1319	143	1	humanized	humanize	VERB
dti-1319	143	2	antibodies	antibody	NOUN
dti-1319	143	3	and	and	CCONJ
dti-1319	143	4	single	single	ADJ
dti-1319	143	5	chain	chain	NOUN
dti-1319	143	6	variable	variable	NOUN
dti-1319	143	7	fragments	fragment	NOUN
dti-1319	143	8	generated	generate	VERB
dti-1319	143	9	by	by	ADP
dti-1319	143	10	murine	murine	ADJ
dti-1319	143	11	hybridomas	hybridoma	NOUN
dti-1319	143	12	or	or	CCONJ
dti-1319	143	13	phage	phage	NOUN
dti-1319	143	14	displayed	display	VERB
dti-1319	143	15	,	,	PUNCT
dti-1319	143	16	minibodies	minibodie	NOUN
dti-1319	143	17	and	and	CCONJ
dti-1319	143	18	peptides	peptide	NOUN
dti-1319	143	19	were	be	AUX
dti-1319	143	20	among	among	ADP
dti-1319	143	21	the	the	DET
dti-1319	143	22	tested	test	VERB
dti-1319	143	23	delivery	delivery	NOUN
dti-1319	143	24	vehicles	vehicle	NOUN
dti-1319	143	25	(	(	PUNCT
dti-1319	143	26	reviewed	review	VERB
dti-1319	143	27	by	by	ADP
dti-1319	143	28	weiner	weiner	NOUN
dti-1319	143	29	and	and	CCONJ
dti-1319	143	30	adams	adam	NOUN
dti-1319	143	31	,	,	PUNCT
dti-1319	143	32	2000	2000	NUM
dti-1319	143	33	)	)	PUNCT
dti-1319	143	34	.	.	PUNCT
dti-1319	144	1	for	for	ADP
dti-1319	144	2	the	the	DET
dti-1319	144	3	development	development	NOUN
dti-1319	144	4	of	of	ADP
dti-1319	144	5	vehicles	vehicle	NOUN
dti-1319	144	6	,	,	PUNCT
dti-1319	144	7	some	some	DET
dti-1319	144	8	pre	pre	NOUN
dti-1319	144	9	-	-	NOUN
dti-1319	144	10	requisites	requisite	NOUN
dti-1319	144	11	must	must	AUX
dti-1319	144	12	be	be	AUX
dti-1319	144	13	satisfi	satisfi	ADJ
dti-1319	144	14	ed	ed	NOUN
dti-1319	144	15	in	in	ADP
dti-1319	144	16	order	order	NOUN
dti-1319	144	17	to	to	PART
dti-1319	144	18	improve	improve	VERB
dti-1319	144	19	their	their	PRON
dti-1319	144	20	chances	chance	NOUN
dti-1319	144	21	of	of	ADP
dti-1319	144	22	passing	pass	VERB
dti-1319	144	23	functional	functional	ADJ
dti-1319	144	24	and	and	CCONJ
dti-1319	144	25	clinical	clinical	ADJ
dti-1319	144	26	trials	trial	NOUN
dti-1319	144	27	.	.	PUNCT
dti-1319	145	1	the	the	DET
dti-1319	145	2	drug	drug	NOUN
dti-1319	145	3	encapsulating	encapsulate	VERB
dti-1319	145	4	particle	particle	NOUN
dti-1319	145	5	-	-	PUNCT
dti-1319	145	6	system	system	NOUN
dti-1319	145	7	must	must	AUX
dti-1319	145	8	be	be	AUX
dti-1319	145	9	composed	compose	VERB
dti-1319	145	10	of	of	ADP
dti-1319	145	11	biocompatible	biocompatible	ADJ
dti-1319	145	12	,	,	PUNCT
dti-1319	145	13	biodegradable	biodegradable	ADJ
dti-1319	145	14	polymers	polymer	NOUN
dti-1319	145	15	approved	approve	VERB
dti-1319	145	16	for	for	ADP
dti-1319	145	17	clinical	clinical	ADJ
dti-1319	145	18	use	use	NOUN
dti-1319	145	19	by	by	ADP
dti-1319	145	20	the	the	DET
dti-1319	145	21	drug	drug	NOUN
dti-1319	145	22	regulating	regulating	NOUN
dti-1319	145	23	agencies	agency	NOUN
dti-1319	145	24	.	.	PUNCT
dti-1319	146	1	moreover	moreover	ADV
dti-1319	146	2	,	,	PUNCT
dti-1319	146	3	the	the	DET
dti-1319	146	4	vessel	vessel	NOUN
dti-1319	146	5	particles	particle	NOUN
dti-1319	146	6	must	must	AUX
dti-1319	146	7	effi	effi	PROPN
dti-1319	146	8	ciently	ciently	ADV
dti-1319	146	9	bind	bind	VERB
dti-1319	146	10	the	the	DET
dti-1319	146	11	negative	negative	ADJ
dti-1319	146	12	charges	charge	NOUN
dti-1319	146	13	of	of	ADP
dti-1319	146	14	na	na	INTJ
dti-1319	146	15	chains	chain	NOUN
dti-1319	146	16	while	while	SCONJ
dti-1319	146	17	minimally	minimally	ADV
dti-1319	146	18	adverse	adverse	ADJ
dti-1319	146	19	-	-	PUNCT
dti-1319	146	20	effecting	effect	VERB
dti-1319	146	21	their	their	PRON
dti-1319	146	22	tridimensional	tridimensional	ADJ
dti-1319	146	23	folding	folding	NOUN
dti-1319	146	24	and	and	CCONJ
dti-1319	146	25	thus	thus	ADV
dti-1319	146	26	their	their	PRON
dti-1319	146	27	binding	bind	VERB
dti-1319	146	28	properties	property	NOUN
dti-1319	146	29	.	.	PUNCT
dti-1319	147	1	the	the	DET
dti-1319	147	2	delivery	delivery	NOUN
dti-1319	147	3	vessels	vessel	NOUN
dti-1319	147	4	must	must	AUX
dti-1319	147	5	yet	yet	ADV
dti-1319	147	6	effi	effi	PROPN
dti-1319	147	7	ciently	ciently	ADV
dti-1319	147	8	and	and	CCONJ
dti-1319	147	9	selectively	selectively	ADV
dti-1319	147	10	bind	bind	VERB
dti-1319	147	11	to	to	ADP
dti-1319	147	12	target	target	NOUN
dti-1319	147	13	cells	cell	NOUN
dti-1319	147	14	,	,	PUNCT
dti-1319	147	15	as	as	ADV
dti-1319	147	16	well	well	ADV
dti-1319	147	17	as	as	ADP
dti-1319	147	18	have	have	VERB
dti-1319	147	19	a	a	DET
dti-1319	147	20	long	long	ADJ
dti-1319	147	21	half	half	ADJ
dti-1319	147	22	-	-	PUNCT
dti-1319	147	23	life	life	NOUN
dti-1319	147	24	in	in	ADP
dti-1319	147	25	circulation	circulation	NOUN
dti-1319	147	26	in	in	ADP
dti-1319	147	27	order	order	NOUN
dti-1319	147	28	to	to	PART
dti-1319	147	29	reach	reach	VERB
dti-1319	147	30	the	the	DET
dti-1319	147	31	target	target	NOUN
dti-1319	147	32	before	before	ADP
dti-1319	147	33	being	be	AUX
dti-1319	147	34	degraded	degrade	VERB
dti-1319	147	35	and	and	CCONJ
dti-1319	147	36	releasing	release	VERB
dti-1319	147	37	their	their	PRON
dti-1319	147	38	contents	content	NOUN
dti-1319	147	39	.	.	PUNCT
dti-1319	148	1	vehicles	vehicle	NOUN
dti-1319	148	2	may	may	AUX
dti-1319	148	3	be	be	AUX
dti-1319	148	4	classifi	classifi	ADJ
dti-1319	148	5	ed	ed	NOUN
dti-1319	148	6	as	as	SCONJ
dti-1319	148	7	such	such	ADJ
dti-1319	148	8	(	(	PUNCT
dti-1319	148	9	i	i	NOUN
dti-1319	148	10	)	)	PUNCT
dti-1319	148	11	improving	improve	VERB
dti-1319	148	12	oligonucleotide	oligonucleotide	ADJ
dti-1319	148	13	pharmacokinetics	pharmacokinetic	NOUN
dti-1319	148	14	by	by	ADP
dti-1319	148	15	attaching	attach	VERB
dti-1319	148	16	a	a	DET
dti-1319	148	17	high	high	ADJ
dti-1319	148	18	-	-	PUNCT
dti-1319	148	19	molecular	molecular	ADJ
dti-1319	148	20	weight	weight	NOUN
dti-1319	148	21	lipophilic	lipophilic	ADJ
dti-1319	148	22	molecule	molecule	NOUN
dti-1319	148	23	to	to	ADP
dti-1319	148	24	an	an	DET
dti-1319	148	25	aptamer	aptamer	NOUN
dti-1319	148	26	in	in	ADP
dti-1319	148	27	order	order	NOUN
dti-1319	148	28	to	to	PART
dti-1319	148	29	augment	augment	VERB
dti-1319	148	30	the	the	DET
dti-1319	148	31	half	half	ADJ
dti-1319	148	32	-	-	PUNCT
dti-1319	148	33	life	life	NOUN
dti-1319	148	34	of	of	ADP
dti-1319	148	35	a	a	DET
dti-1319	148	36	therapeutic	therapeutic	ADJ
dti-1319	148	37	oligonucleotide	oligonucleotide	NOUN
dti-1319	148	38	in	in	ADP
dti-1319	148	39	the	the	DET
dti-1319	148	40	plasma	plasma	NOUN
dti-1319	148	41	,	,	PUNCT
dti-1319	148	42	and	and	CCONJ
dti-1319	148	43	as	as	ADP
dti-1319	148	44	189	189	NUM
dti-1319	148	45	delivery	delivery	NOUN
dti-1319	148	46	systems	system	NOUN
dti-1319	148	47	of	of	ADP
dti-1319	148	48	nucleic	nucleic	ADJ
dti-1319	148	49	acids	acid	NOUN
dti-1319	148	50	drugs	drug	NOUN
dti-1319	148	51	drug	drug	NOUN
dti-1319	148	52	target	target	NOUN
dti-1319	148	53	insights	insight	NOUN
dti-1319	148	54	2007:2	2007:2	NUM
dti-1319	148	55	such	such	ADJ
dti-1319	148	56	(	(	PUNCT
dti-1319	148	57	ii	ii	NOUN
dti-1319	148	58	)	)	PUNCT
dti-1319	148	59	permitting	permit	VERB
dti-1319	148	60	the	the	DET
dti-1319	148	61	immobilized	immobilized	ADJ
dti-1319	148	62	oligonucleotide	oligonucleotide	NOUN
dti-1319	148	63	to	to	PART
dti-1319	148	64	pass	pass	VERB
dti-1319	148	65	physiological	physiological	ADJ
dti-1319	148	66	barriers	barrier	NOUN
dti-1319	148	67	such	such	ADJ
dti-1319	148	68	as	as	ADP
dti-1319	148	69	the	the	DET
dti-1319	148	70	brainblood	brainblood	NOUN
dti-1319	148	71	barrier	barrier	NOUN
dti-1319	148	72	or	or	CCONJ
dti-1319	148	73	plasma	plasma	NOUN
dti-1319	148	74	membranes	membrane	NOUN
dti-1319	148	75	to	to	PART
dti-1319	148	76	be	be	AUX
dti-1319	148	77	delivered	deliver	VERB
dti-1319	148	78	into	into	ADP
dti-1319	148	79	cells	cell	NOUN
dti-1319	148	80	.	.	PUNCT
dti-1319	149	1	in	in	ADP
dti-1319	149	2	addition	addition	NOUN
dti-1319	149	3	to	to	ADP
dti-1319	149	4	their	their	PRON
dti-1319	149	5	ability	ability	NOUN
dti-1319	149	6	to	to	PART
dti-1319	149	7	act	act	VERB
dti-1319	149	8	as	as	ADP
dti-1319	149	9	therapeutic	therapeutic	ADJ
dti-1319	149	10	drugs	drug	NOUN
dti-1319	149	11	by	by	ADP
dti-1319	149	12	themselves	themselves	PRON
dti-1319	149	13	,	,	PUNCT
dti-1319	149	14	aptamers	aptamer	NOUN
dti-1319	149	15	can	can	AUX
dti-1319	149	16	also	also	ADV
dti-1319	149	17	be	be	AUX
dti-1319	149	18	used	use	VERB
dti-1319	149	19	as	as	ADP
dti-1319	149	20	vehicles	vehicle	NOUN
dti-1319	149	21	themselves	themselves	PRON
dti-1319	149	22	to	to	PART
dti-1319	149	23	deliver	deliver	VERB
dti-1319	149	24	another	another	DET
dti-1319	149	25	oligonucleotides	oligonucleotide	NOUN
dti-1319	149	26	to	to	PART
dti-1319	149	27	specifi	specifi	PROPN
dti-1319	149	28	c	c	PROPN
dti-1319	149	29	target	target	NOUN
dti-1319	149	30	cells	cell	NOUN
dti-1319	149	31	(	(	PUNCT
dti-1319	149	32	farokhzad	farokhzad	ADV
dti-1319	149	33	et	et	PROPN
dti-1319	149	34	al	al	PROPN
dti-1319	149	35	.	.	PROPN
dti-1319	149	36	2006	2006	NUM
dti-1319	149	37	)	)	PUNCT
dti-1319	149	38	.	.	PUNCT
dti-1319	150	1	applications	application	NOUN
dti-1319	150	2	for	for	ADP
dti-1319	150	3	oligonucleotidedirected	oligonucleotidedirecte	VERB
dti-1319	150	4	drug	drug	NOUN
dti-1319	150	5	delivery	delivery	NOUN
dti-1319	150	6	prostate	prostate	NOUN
dti-1319	150	7	-	-	PUNCT
dti-1319	150	8	specifi	specifi	PROPN
dti-1319	150	9	c	c	PROPN
dti-1319	150	10	membrane	membrane	NOUN
dti-1319	150	11	antigen	antigen	NOUN
dti-1319	150	12	(	(	PUNCT
dti-1319	150	13	psma	psma	PROPN
dti-1319	150	14	)	)	PUNCT
dti-1319	150	15	is	be	AUX
dti-1319	150	16	a	a	DET
dti-1319	150	17	type-2	type-2	NUM
dti-1319	150	18	integral	integral	ADJ
dti-1319	150	19	membrane	membrane	NOUN
dti-1319	150	20	glycoprotein	glycoprotein	NOUN
dti-1319	150	21	,	,	PUNCT
dti-1319	150	22	expressed	express	VERB
dti-1319	150	23	at	at	ADP
dti-1319	150	24	the	the	DET
dti-1319	150	25	prostate	prostate	NOUN
dti-1319	150	26	carcinoma	carcinoma	NOUN
dti-1319	150	27	surface	surface	NOUN
dti-1319	150	28	and	and	CCONJ
dti-1319	150	29	on	on	ADP
dti-1319	150	30	new	new	ADJ
dti-1319	150	31	vessels	vessel	NOUN
dti-1319	150	32	formed	form	VERB
dti-1319	150	33	by	by	ADP
dti-1319	150	34	various	various	ADJ
dti-1319	150	35	other	other	ADJ
dti-1319	150	36	solid	solid	ADJ
dti-1319	150	37	tumors	tumor	NOUN
dti-1319	150	38	.	.	PUNCT
dti-1319	151	1	this	this	DET
dti-1319	151	2	antigen	antigen	NOUN
dti-1319	151	3	is	be	AUX
dti-1319	151	4	highly	highly	ADV
dti-1319	151	5	expressed	express	VERB
dti-1319	151	6	in	in	ADP
dti-1319	151	7	every	every	DET
dti-1319	151	8	stage	stage	NOUN
dti-1319	151	9	of	of	ADP
dti-1319	151	10	prostate	prostate	NOUN
dti-1319	151	11	cancer	cancer	NOUN
dti-1319	151	12	development	development	NOUN
dti-1319	151	13	(	(	PUNCT
dti-1319	151	14	rajasekaran	rajasekaran	NOUN
dti-1319	151	15	et	et	PROPN
dti-1319	151	16	al	al	PROPN
dti-1319	151	17	.	.	PROPN
dti-1319	151	18	2005	2005	NUM
dti-1319	151	19	)	)	PUNCT
dti-1319	152	1	and	and	CCONJ
dti-1319	152	2	,	,	PUNCT
dti-1319	152	3	therefore	therefore	ADV
dti-1319	152	4	,	,	PUNCT
dti-1319	152	5	is	be	AUX
dti-1319	152	6	a	a	DET
dti-1319	152	7	strong	strong	ADJ
dti-1319	152	8	molecular	molecular	ADJ
dti-1319	152	9	target	target	NOUN
dti-1319	152	10	candidate	candidate	NOUN
dti-1319	152	11	for	for	ADP
dti-1319	152	12	immunotherapy	immunotherapy	NOUN
dti-1319	152	13	and	and	CCONJ
dti-1319	152	14	prostate	prostate	NOUN
dti-1319	152	15	-	-	PUNCT
dti-1319	152	16	cancer	cancer	NOUN
dti-1319	152	17	imaging	imaging	NOUN
dti-1319	152	18	.	.	PUNCT
dti-1319	153	1	previous	previous	ADJ
dti-1319	153	2	efforts	effort	NOUN
dti-1319	153	3	to	to	PART
dti-1319	153	4	selectively	selectively	ADV
dti-1319	153	5	destroy	destroy	VERB
dti-1319	153	6	cancer	cancer	NOUN
dti-1319	153	7	cells	cell	NOUN
dti-1319	153	8	generally	generally	ADV
dti-1319	153	9	have	have	AUX
dti-1319	153	10	made	make	VERB
dti-1319	153	11	use	use	NOUN
dti-1319	153	12	of	of	ADP
dti-1319	153	13	antibodies	antibody	NOUN
dti-1319	153	14	to	to	PART
dti-1319	153	15	deliver	deliver	VERB
dti-1319	153	16	cytotoxic	cytotoxic	ADJ
dti-1319	153	17	packages	package	NOUN
dti-1319	153	18	(	(	PUNCT
dti-1319	153	19	wu	wu	PROPN
dti-1319	153	20	and	and	CCONJ
dti-1319	153	21	senter	senter	NOUN
dti-1319	153	22	,	,	PUNCT
dti-1319	153	23	2005	2005	NUM
dti-1319	153	24	)	)	PUNCT
dti-1319	153	25	.	.	PUNCT
dti-1319	154	1	however	however	ADV
dti-1319	154	2	,	,	PUNCT
dti-1319	154	3	aptamers	aptamer	NOUN
dti-1319	154	4	developed	develop	VERB
dti-1319	154	5	against	against	ADP
dti-1319	154	6	psma	psma	NOUN
dti-1319	154	7	as	as	ADP
dti-1319	154	8	protein	protein	NOUN
dti-1319	154	9	or	or	CCONJ
dti-1319	154	10	another	another	DET
dti-1319	154	11	molecule	molecule	NOUN
dti-1319	154	12	of	of	ADP
dti-1319	154	13	biological	biological	ADJ
dti-1319	154	14	importance	importance	NOUN
dti-1319	154	15	potent	potent	NOUN
dti-1319	154	16	target	target	NOUN
dti-1319	154	17	binders	binder	NOUN
dti-1319	154	18	can	can	AUX
dti-1319	154	19	be	be	AUX
dti-1319	154	20	used	use	VERB
dti-1319	154	21	instead	instead	ADV
dti-1319	154	22	of	of	ADP
dti-1319	154	23	antibodies	antibody	NOUN
dti-1319	154	24	to	to	PART
dti-1319	154	25	deliver	deliver	VERB
dti-1319	154	26	cytotoxic	cytotoxic	ADJ
dti-1319	154	27	agents	agent	NOUN
dti-1319	154	28	to	to	ADP
dti-1319	154	29	cancer	cancer	NOUN
dti-1319	154	30	cells	cell	NOUN
dti-1319	154	31	(	(	PUNCT
dti-1319	154	32	farokhzad	farokhzad	ADV
dti-1319	154	33	et	et	PROPN
dti-1319	154	34	al	al	PROPN
dti-1319	154	35	.	.	PROPN
dti-1319	154	36	2006	2006	NUM
dti-1319	154	37	)	)	PUNCT
dti-1319	154	38	.	.	PUNCT
dti-1319	155	1	gelonin	gelonin	PROPN
dti-1319	155	2	(	(	PUNCT
dti-1319	155	3	gel	gel	NOUN
dti-1319	155	4	)	)	PUNCT
dti-1319	155	5	is	be	AUX
dti-1319	155	6	a	a	DET
dti-1319	155	7	protein	protein	NOUN
dti-1319	155	8	toxin	toxin	NOUN
dti-1319	155	9	with	with	ADP
dti-1319	155	10	n	n	CCONJ
dti-1319	155	11	-	-	PUNCT
dti-1319	155	12	glycosidase	glycosidase	NOUN
dti-1319	155	13	activity	activity	NOUN
dti-1319	155	14	promoting	promote	VERB
dti-1319	155	15	cell	cell	NOUN
dti-1319	155	16	death	death	NOUN
dti-1319	155	17	by	by	ADP
dti-1319	155	18	cleavage	cleavage	NOUN
dti-1319	155	19	of	of	ADP
dti-1319	155	20	a	a	DET
dti-1319	155	21	specific	specific	ADJ
dti-1319	155	22	glycosidic	glycosidic	ADJ
dti-1319	155	23	bond	bond	NOUN
dti-1319	155	24	of	of	ADP
dti-1319	155	25	rrna	rrna	NOUN
dti-1319	155	26	thereby	thereby	ADV
dti-1319	155	27	promoting	promote	VERB
dti-1319	155	28	inhibition	inhibition	NOUN
dti-1319	155	29	of	of	ADP
dti-1319	155	30	protein	protein	NOUN
dti-1319	155	31	synthesis	synthesis	NOUN
dti-1319	155	32	and	and	CCONJ
dti-1319	155	33	resulting	result	VERB
dti-1319	155	34	in	in	ADP
dti-1319	155	35	elimination	elimination	NOUN
dti-1319	155	36	of	of	ADP
dti-1319	155	37	target	target	NOUN
dti-1319	155	38	cells	cell	NOUN
dti-1319	155	39	.	.	PUNCT
dti-1319	156	1	however	however	ADV
dti-1319	156	2	,	,	PUNCT
dti-1319	156	3	gelonin	gelonin	PROPN
dti-1319	156	4	does	do	AUX
dti-1319	156	5	not	not	PART
dti-1319	156	6	contain	contain	VERB
dti-1319	156	7	a	a	DET
dti-1319	156	8	translocation	translocation	NOUN
dti-1319	156	9	domain	domain	NOUN
dti-1319	156	10	such	such	ADJ
dti-1319	156	11	as	as	ADP
dti-1319	156	12	those	those	PRON
dti-1319	156	13	of	of	ADP
dti-1319	156	14	many	many	ADJ
dti-1319	156	15	other	other	ADJ
dti-1319	156	16	ribosomal	ribosomal	NOUN
dti-1319	156	17	toxins	toxin	NOUN
dti-1319	156	18	do	do	AUX
dti-1319	156	19	,	,	PUNCT
dti-1319	156	20	and	and	CCONJ
dti-1319	156	21	is	be	AUX
dti-1319	156	22	not	not	PART
dti-1319	156	23	incorporated	incorporate	VERB
dti-1319	156	24	into	into	ADP
dti-1319	156	25	cells	cell	NOUN
dti-1319	156	26	at	at	ADP
dti-1319	156	27	considerable	considerable	ADJ
dti-1319	156	28	quantities	quantity	NOUN
dti-1319	156	29	(	(	PUNCT
dti-1319	156	30	rosenblum	rosenblum	PROPN
dti-1319	156	31	et	et	PROPN
dti-1319	156	32	al	al	PROPN
dti-1319	156	33	.	.	PROPN
dti-1319	156	34	1999	1999	NUM
dti-1319	156	35	)	)	PUNCT
dti-1319	156	36	.	.	PUNCT
dti-1319	157	1	in	in	ADP
dti-1319	157	2	order	order	NOUN
dti-1319	157	3	to	to	PART
dti-1319	157	4	further	far	ADV
dti-1319	157	5	improve	improve	VERB
dti-1319	157	6	its	its	PRON
dti-1319	157	7	cytotoxicity	cytotoxicity	NOUN
dti-1319	157	8	,	,	PUNCT
dti-1319	157	9	a	a	DET
dti-1319	157	10	recombinant	recombinant	ADJ
dti-1319	157	11	gel	gel	NOUN
dti-1319	157	12	(	(	PUNCT
dti-1319	157	13	rgel	rgel	NOUN
dti-1319	157	14	)	)	PUNCT
dti-1319	157	15	was	be	AUX
dti-1319	157	16	developed	develop	VERB
dti-1319	157	17	.	.	PUNCT
dti-1319	158	1	although	although	SCONJ
dti-1319	158	2	this	this	DET
dti-1319	158	3	recombinant	recombinant	ADJ
dti-1319	158	4	variant	variant	NOUN
dti-1319	158	5	provoked	provoke	VERB
dti-1319	158	6	some	some	DET
dti-1319	158	7	toxicity	toxicity	NOUN
dti-1319	158	8	on	on	ADP
dti-1319	158	9	target	target	NOUN
dti-1319	158	10	cells	cell	NOUN
dti-1319	158	11	,	,	PUNCT
dti-1319	158	12	membrane	membrane	NOUN
dti-1319	158	13	-	-	PUNCT
dti-1319	158	14	permeability	permeability	NOUN
dti-1319	158	15	was	be	AUX
dti-1319	158	16	not	not	PART
dti-1319	158	17	signifi	signifi	NOUN
dti-1319	158	18	cantly	cantly	ADV
dti-1319	158	19	improved	improve	VERB
dti-1319	158	20	(	(	PUNCT
dti-1319	158	21	rosenblum	rosenblum	PROPN
dti-1319	158	22	et	et	PROPN
dti-1319	158	23	al	al	PROPN
dti-1319	158	24	.	.	PROPN
dti-1319	158	25	1999	1999	NUM
dti-1319	158	26	)	)	PUNCT
dti-1319	158	27	.	.	PUNCT
dti-1319	159	1	this	this	DET
dti-1319	159	2	problem	problem	NOUN
dti-1319	159	3	was	be	AUX
dti-1319	159	4	solved	solve	VERB
dti-1319	159	5	by	by	ADP
dti-1319	159	6	chemical	chemical	ADJ
dti-1319	159	7	conjugation	conjugation	NOUN
dti-1319	159	8	of	of	ADP
dti-1319	159	9	rgel	rgel	NOUN
dti-1319	159	10	or	or	CCONJ
dti-1319	159	11	its	its	PRON
dti-1319	159	12	genetic	genetic	ADJ
dti-1319	159	13	fusion	fusion	NOUN
dti-1319	159	14	with	with	ADP
dti-1319	159	15	the	the	DET
dti-1319	159	16	delivery	delivery	NOUN
dti-1319	159	17	package	package	NOUN
dti-1319	159	18	’s	’s	PART
dti-1319	159	19	recognition	recognition	NOUN
dti-1319	159	20	molecules	molecule	NOUN
dti-1319	159	21	and	and	CCONJ
dti-1319	159	22	by	by	ADP
dti-1319	159	23	addition	addition	NOUN
dti-1319	159	24	of	of	ADP
dti-1319	159	25	cysteine	cysteine	NOUN
dti-1319	159	26	residues	residue	NOUN
dti-1319	159	27	to	to	PART
dti-1319	159	28	form	form	VERB
dti-1319	159	29	antibody	antibody	NOUN
dti-1319	159	30	immunoconjugates	immunoconjugate	VERB
dti-1319	159	31	(	(	PUNCT
dti-1319	159	32	rosenblum	rosenblum	PROPN
dti-1319	159	33	et	et	PROPN
dti-1319	159	34	al	al	PROPN
dti-1319	159	35	.	.	PROPN
dti-1319	159	36	2003	2003	NUM
dti-1319	159	37	;	;	PUNCT
dti-1319	159	38	better	well	ADJ
dti-1319	159	39	et	et	PROPN
dti-1319	159	40	al	al	PROPN
dti-1319	159	41	.	.	PROPN
dti-1319	159	42	1994	1994	NUM
dti-1319	159	43	)	)	PUNCT
dti-1319	159	44	.	.	PUNCT
dti-1319	160	1	for	for	ADP
dti-1319	160	2	instance	instance	NOUN
dti-1319	160	3	,	,	PUNCT
dti-1319	160	4	the	the	DET
dti-1319	160	5	cytokine	cytokine	NOUN
dti-1319	160	6	vegf	vegf	PROPN
dti-1319	160	7	was	be	AUX
dti-1319	160	8	coupled	couple	VERB
dti-1319	160	9	to	to	ADP
dti-1319	160	10	gelonin	gelonin	PROPN
dti-1319	160	11	and	and	CCONJ
dti-1319	160	12	the	the	DET
dti-1319	160	13	resulting	result	VERB
dti-1319	160	14	conjugate	conjugate	ADJ
dti-1319	160	15	specifi	specifi	PROPN
dti-1319	160	16	cally	cally	ADV
dti-1319	160	17	killed	kill	VERB
dti-1319	160	18	cancer	cancer	NOUN
dti-1319	160	19	cells	cell	NOUN
dti-1319	160	20	overexpressing	overexpresse	VERB
dti-1319	160	21	the	the	DET
dti-1319	160	22	vegf	vegf	NOUN
dti-1319	160	23	receptor	receptor	NOUN
dti-1319	160	24	flt-1	flt-1	PUNCT
dti-1319	160	25	(	(	PUNCT
dti-1319	160	26	veenendaal	veenendaal	NOUN
dti-1319	160	27	et	et	PROPN
dti-1319	160	28	al	al	PROPN
dti-1319	160	29	.	.	PROPN
dti-1319	160	30	2002	2002	NUM
dti-1319	160	31	)	)	PUNCT
dti-1319	160	32	.	.	PUNCT
dti-1319	161	1	a	a	DET
dti-1319	161	2	selective	selective	ADJ
dti-1319	161	3	drug	drug	NOUN
dti-1319	161	4	that	that	PRON
dti-1319	161	5	can	can	AUX
dti-1319	161	6	home	home	VERB
dti-1319	161	7	in	in	ADP
dti-1319	161	8	a	a	DET
dti-1319	161	9	specifi	specifi	PROPN
dti-1319	161	10	c	c	PROPN
dti-1319	161	11	target	target	NOUN
dti-1319	161	12	cell	cell	NOUN
dti-1319	161	13	or	or	CCONJ
dti-1319	161	14	tissue	tissue	NOUN
dti-1319	161	15	as	as	SCONJ
dti-1319	161	16	therapeutical	therapeutical	ADJ
dti-1319	161	17	nanoparticle	nanoparticle	NOUN
dti-1319	161	18	is	be	AUX
dti-1319	161	19	the	the	DET
dti-1319	161	20	most	most	ADV
dti-1319	161	21	desirable	desirable	ADJ
dti-1319	161	22	aim	aim	NOUN
dti-1319	161	23	of	of	ADP
dti-1319	161	24	any	any	DET
dti-1319	161	25	delivery	delivery	NOUN
dti-1319	161	26	system	system	NOUN
dti-1319	161	27	.	.	PUNCT
dti-1319	162	1	previously	previously	ADV
dti-1319	162	2	selected	select	VERB
dti-1319	162	3	rna	rna	NOUN
dti-1319	162	4	aptamers	aptamer	NOUN
dti-1319	162	5	specifi	specifi	VERB
dti-1319	162	6	cally	cally	ADV
dti-1319	162	7	binding	bind	VERB
dti-1319	162	8	to	to	ADP
dti-1319	162	9	psma	psma	PROPN
dti-1319	162	10	were	be	AUX
dti-1319	162	11	used	use	VERB
dti-1319	162	12	to	to	PART
dti-1319	162	13	escort	escort	VERB
dti-1319	162	14	gel	gel	NOUN
dti-1319	162	15	to	to	ADP
dti-1319	162	16	tumoral	tumoral	ADJ
dti-1319	162	17	cells	cell	NOUN
dti-1319	162	18	expressing	express	VERB
dti-1319	162	19	psma	psma	NOUN
dti-1319	162	20	at	at	ADP
dti-1319	162	21	their	their	PRON
dti-1319	162	22	surface	surface	NOUN
dti-1319	162	23	.	.	PUNCT
dti-1319	163	1	the	the	DET
dti-1319	163	2	conjugated	conjugated	ADJ
dti-1319	163	3	toxin	toxin	NOUN
dti-1319	163	4	destroyed	destroy	VERB
dti-1319	163	5	prostate	prostate	NOUN
dti-1319	163	6	cancer	cancer	NOUN
dti-1319	163	7	cells	cell	NOUN
dti-1319	163	8	with	with	ADP
dti-1319	163	9	an	an	DET
dti-1319	163	10	ic50	ic50	PROPN
dti-1319	163	11	value	value	NOUN
dti-1319	163	12	of	of	ADP
dti-1319	163	13	27	27	NUM
dti-1319	163	14	nm	nm	NOUN
dti-1319	163	15	,	,	PUNCT
dti-1319	163	16	presenting	present	VERB
dti-1319	163	17	an	an	DET
dti-1319	163	18	increase	increase	NOUN
dti-1319	163	19	in	in	ADP
dti-1319	163	20	toxicity	toxicity	NOUN
dti-1319	163	21	of	of	ADP
dti-1319	163	22	more	more	ADJ
dti-1319	163	23	than	than	ADP
dti-1319	163	24	600	600	NUM
dti-1319	163	25	times	time	NOUN
dti-1319	163	26	in	in	ADP
dti-1319	163	27	comparison	comparison	NOUN
dti-1319	163	28	to	to	ADP
dti-1319	163	29	cells	cell	NOUN
dti-1319	163	30	which	which	PRON
dti-1319	163	31	do	do	AUX
dti-1319	163	32	not	not	PART
dti-1319	163	33	express	express	VERB
dti-1319	163	34	psma	psma	NOUN
dti-1319	163	35	(	(	PUNCT
dti-1319	163	36	chu	chu	PROPN
dti-1319	163	37	et	et	PROPN
dti-1319	163	38	al	al	PROPN
dti-1319	163	39	.	.	PROPN
dti-1319	163	40	2006	2006	NUM
dti-1319	163	41	)	)	PUNCT
dti-1319	163	42	.	.	PUNCT
dti-1319	164	1	the	the	DET
dti-1319	164	2	extracellular	extracellular	ADJ
dti-1319	164	3	domain	domain	NOUN
dti-1319	164	4	of	of	ADP
dti-1319	164	5	psma	psma	NOUN
dti-1319	164	6	can	can	AUX
dti-1319	164	7	now	now	ADV
dti-1319	164	8	be	be	AUX
dti-1319	164	9	recognized	recognize	VERB
dti-1319	164	10	by	by	ADP
dti-1319	164	11	a	a	DET
dti-1319	164	12	biocompatible	biocompatible	ADJ
dti-1319	164	13	and	and	CCONJ
dti-1319	164	14	biodegradable	biodegradable	ADJ
dti-1319	164	15	polymeric	polymeric	ADJ
dti-1319	164	16	nanoparticle	nanoparticle	NOUN
dti-1319	164	17	encapsulated	encapsulate	VERB
dti-1319	164	18	with	with	ADP
dti-1319	164	19	a	a	DET
dti-1319	164	20	docetaxel	docetaxel	NOUN
dti-1319	164	21	(	(	PUNCT
dti-1319	164	22	dtxl	dtxl	NOUN
dti-1319	164	23	)	)	PUNCT
dti-1319	164	24	surface	surface	NOUN
dti-1319	164	25	functionalized	functionalize	VERB
dti-1319	164	26	with	with	ADP
dti-1319	164	27	a	a	DET
dti-1319	164	28	stable	stable	ADJ
dti-1319	164	29	,	,	PUNCT
dti-1319	164	30	nuclease	nuclease	NOUN
dti-1319	164	31	-	-	PUNCT
dti-1319	164	32	resistant	resistant	ADJ
dti-1319	164	33	rna	rna	NOUN
dti-1319	164	34	aptamer	aptamer	NOUN
dti-1319	164	35	containing	contain	VERB
dti-1319	164	36	2′-f	2′-f	NOUN
dti-1319	164	37	-	-	PUNCT
dti-1319	164	38	modified	modify	VERB
dti-1319	164	39	pyrimidine	pyrimidine	NOUN
dti-1319	164	40	bases	basis	NOUN
dti-1319	164	41	(	(	PUNCT
dti-1319	164	42	farokhzad	farokhzad	ADV
dti-1319	164	43	et	et	PROPN
dti-1319	164	44	al	al	PROPN
dti-1319	164	45	.	.	PROPN
dti-1319	164	46	2006	2006	NUM
dti-1319	164	47	)	)	PUNCT
dti-1319	164	48	.	.	PUNCT
dti-1319	165	1	these	these	DET
dti-1319	165	2	aptamernanoparticle	aptamernanoparticle	NOUN
dti-1319	165	3	bioconjugates	bioconjugate	VERB
dti-1319	165	4	(	(	PUNCT
dti-1319	165	5	dtxl	dtxl	NOUN
dti-1319	165	6	-	-	PUNCT
dti-1319	165	7	np	np	NOUN
dti-1319	165	8	-	-	PUNCT
dti-1319	165	9	apt	apt	ADJ
dti-1319	165	10	)	)	PUNCT
dti-1319	165	11	bound	bind	VERB
dti-1319	165	12	to	to	PART
dti-1319	165	13	psma	psma	VERB
dti-1319	165	14	proteins	protein	NOUN
dti-1319	165	15	expressed	express	VERB
dti-1319	165	16	at	at	ADP
dti-1319	165	17	the	the	DET
dti-1319	165	18	surface	surface	NOUN
dti-1319	165	19	of	of	ADP
dti-1319	165	20	prostate	prostate	NOUN
dti-1319	165	21	epithelial	epithelial	ADJ
dti-1319	165	22	cells	cell	NOUN
dti-1319	165	23	lncap	lncap	NOUN
dti-1319	165	24	were	be	AUX
dti-1319	165	25	easily	easily	ADV
dti-1319	165	26	incorporated	incorporate	VERB
dti-1319	165	27	by	by	ADP
dti-1319	165	28	cancer	cancer	NOUN
dti-1319	165	29	cells	cell	NOUN
dti-1319	165	30	with	with	ADP
dti-1319	165	31	cytotoxic	cytotoxic	ADJ
dti-1319	165	32	effects	effect	NOUN
dti-1319	165	33	in	in	ADP
dti-1319	165	34	vitro	vitro	X
dti-1319	165	35	.	.	PUNCT
dti-1319	166	1	encouragingly	encouragingly	ADV
dti-1319	166	2	,	,	PUNCT
dti-1319	166	3	dtxl	dtxl	NOUN
dti-1319	166	4	-	-	PUNCT
dti-1319	166	5	np	np	ADV
dti-1319	166	6	-	-	PUNCT
dti-1319	166	7	apt	apt	ADJ
dti-1319	166	8	bioconjugates	bioconjugate	NOUN
dti-1319	166	9	also	also	ADV
dti-1319	166	10	presented	present	VERB
dti-1319	166	11	remarkable	remarkable	ADJ
dti-1319	166	12	effi	effi	PROPN
dti-1319	166	13	cacy	cacy	NOUN
dti-1319	166	14	and	and	CCONJ
dti-1319	166	15	reduced	reduce	VERB
dti-1319	166	16	side	side	NOUN
dti-1319	166	17	effects	effect	NOUN
dti-1319	166	18	in	in	ADP
dti-1319	166	19	vivo	vivo	NOUN
dti-1319	166	20	.	.	PUNCT
dti-1319	167	1	these	these	DET
dti-1319	167	2	observations	observation	NOUN
dti-1319	167	3	strongly	strongly	ADV
dti-1319	167	4	indicate	indicate	VERB
dti-1319	167	5	a	a	DET
dti-1319	167	6	potential	potential	ADJ
dti-1319	167	7	therapeutic	therapeutic	ADJ
dti-1319	167	8	application	application	NOUN
dti-1319	167	9	of	of	ADP
dti-1319	167	10	aptamer	aptamer	NOUN
dti-1319	167	11	-	-	PUNCT
dti-1319	167	12	nanoparticle	nanoparticle	NOUN
dti-1319	167	13	bioconjugates	bioconjugate	VERB
dti-1319	167	14	to	to	PART
dti-1319	167	15	specifi	specifi	VERB
dti-1319	167	16	cally	cally	ADV
dti-1319	167	17	target	target	VERB
dti-1319	167	18	and	and	CCONJ
dti-1319	167	19	destroy	destroy	VERB
dti-1319	167	20	cancer	cancer	NOUN
dti-1319	167	21	cells	cell	NOUN
dti-1319	167	22	.	.	PUNCT
dti-1319	168	1	another	another	DET
dti-1319	168	2	approach	approach	NOUN
dti-1319	168	3	with	with	ADP
dti-1319	168	4	possible	possible	ADJ
dti-1319	168	5	therapeutic	therapeutic	ADJ
dti-1319	168	6	applications	application	NOUN
dti-1319	168	7	makes	make	VERB
dti-1319	168	8	use	use	NOUN
dti-1319	168	9	of	of	ADP
dti-1319	168	10	packaging	packaging	NOUN
dti-1319	168	11	rna	rna	NOUN
dti-1319	168	12	(	(	PUNCT
dti-1319	168	13	prna	prna	PROPN
dti-1319	168	14	)	)	PUNCT
dti-1319	168	15	as	as	ADP
dti-1319	168	16	part	part	NOUN
dti-1319	168	17	of	of	ADP
dti-1319	168	18	the	the	DET
dti-1319	168	19	dna	dna	ADJ
dti-1319	168	20	-	-	PUNCT
dti-1319	168	21	packaging	packaging	NOUN
dti-1319	168	22	machinery	machinery	NOUN
dti-1319	168	23	of	of	ADP
dti-1319	168	24	the	the	DET
dti-1319	168	25	bacteriophage	bacteriophage	NOUN
dti-1319	168	26	phi29	phi29	NOUN
dti-1319	168	27	.	.	PUNCT
dti-1319	169	1	this	this	DET
dti-1319	169	2	prna	prna	NOUN
dti-1319	169	3	was	be	AUX
dti-1319	169	4	genetically	genetically	ADV
dti-1319	169	5	engineered	engineer	VERB
dti-1319	169	6	to	to	PART
dti-1319	169	7	originate	originate	VERB
dti-1319	169	8	chimeric	chimeric	ADJ
dti-1319	169	9	rna	rna	NOUN
dti-1319	169	10	that	that	PRON
dti-1319	169	11	forms	form	VERB
dti-1319	169	12	dimers	dimer	NOUN
dti-1319	169	13	via	via	ADP
dti-1319	169	14	interlocking	interlock	VERB
dti-1319	169	15	rightand	rightand	NOUN
dti-1319	169	16	left	left	ADJ
dti-1319	169	17	-	-	PUNCT
dti-1319	169	18	handed	hand	VERB
dti-1319	169	19	loops	loop	NOUN
dti-1319	169	20	(	(	PUNCT
dti-1319	169	21	guo	guo	PROPN
dti-1319	169	22	et	et	PROPN
dti-1319	169	23	al	al	PROPN
dti-1319	169	24	.	.	PROPN
dti-1319	169	25	2005	2005	NUM
dti-1319	169	26	)	)	PUNCT
dti-1319	169	27	.	.	PUNCT
dti-1319	170	1	fusing	fuse	VERB
dti-1319	170	2	prna	prna	NOUN
dti-1319	170	3	with	with	ADP
dti-1319	170	4	either	either	CCONJ
dti-1319	170	5	receptor	receptor	NOUN
dti-1319	170	6	-	-	PUNCT
dti-1319	170	7	binding	bind	VERB
dti-1319	170	8	rna	rna	NOUN
dti-1319	170	9	aptamers	aptamer	NOUN
dti-1319	170	10	,	,	PUNCT
dti-1319	170	11	folate	folate	NOUN
dti-1319	170	12	,	,	PUNCT
dti-1319	170	13	small	small	ADJ
dti-1319	170	14	interfering	interfere	VERB
dti-1319	170	15	rna	rna	NOUN
dti-1319	170	16	(	(	PUNCT
dti-1319	170	17	sirna	sirna	PROPN
dti-1319	170	18	)	)	PUNCT
dti-1319	170	19	,	,	PUNCT
dti-1319	170	20	ribozyme	ribozyme	NOUN
dti-1319	170	21	,	,	PUNCT
dti-1319	170	22	or	or	CCONJ
dti-1319	170	23	another	another	DET
dti-1319	170	24	chemical	chemical	NOUN
dti-1319	170	25	group	group	NOUN
dti-1319	170	26	did	do	AUX
dti-1319	170	27	not	not	PART
dti-1319	170	28	disturb	disturb	VERB
dti-1319	170	29	dimer	dimer	NOUN
dti-1319	170	30	formation	formation	NOUN
dti-1319	170	31	or	or	CCONJ
dti-1319	170	32	interfere	interfere	VERB
dti-1319	170	33	with	with	ADP
dti-1319	170	34	the	the	DET
dti-1319	170	35	function	function	NOUN
dti-1319	170	36	of	of	ADP
dti-1319	170	37	the	the	DET
dti-1319	170	38	inserted	insert	VERB
dti-1319	170	39	moieties	moiety	NOUN
dti-1319	170	40	.	.	PUNCT
dti-1319	171	1	incubation	incubation	NOUN
dti-1319	171	2	of	of	ADP
dti-1319	171	3	cancer	cancer	NOUN
dti-1319	171	4	cells	cell	NOUN
dti-1319	171	5	with	with	ADP
dti-1319	171	6	the	the	DET
dti-1319	171	7	prna	prna	NOUN
dti-1319	171	8	dimer	dimer	NOUN
dti-1319	171	9	with	with	ADP
dti-1319	171	10	one	one	NUM
dti-1319	171	11	subunit	subunit	NOUN
dti-1319	171	12	harboring	harbor	VERB
dti-1319	171	13	the	the	DET
dti-1319	171	14	receptor	receptor	NOUN
dti-1319	171	15	-	-	PUNCT
dti-1319	171	16	binding	bind	VERB
dti-1319	171	17	moiety	moiety	NOUN
dti-1319	171	18	and	and	CCONJ
dti-1319	171	19	the	the	DET
dti-1319	171	20	other	other	ADJ
dti-1319	171	21	containining	containine	VERB
dti-1319	171	22	the	the	DET
dti-1319	171	23	gene	gene	NOUN
dti-1319	171	24	expression	expression	NOUN
dti-1319	171	25	-	-	PUNCT
dti-1319	171	26	silencing	silence	VERB
dti-1319	171	27	molecule	molecule	NOUN
dti-1319	171	28	resulted	result	VERB
dti-1319	171	29	in	in	ADP
dti-1319	171	30	targetcell	targetcell	ADJ
dti-1319	171	31	recognition	recognition	NOUN
dti-1319	171	32	,	,	PUNCT
dti-1319	171	33	uptake	uptake	ADJ
dti-1319	171	34	into	into	ADP
dti-1319	171	35	these	these	DET
dti-1319	171	36	cells	cell	NOUN
dti-1319	171	37	and	and	CCONJ
dti-1319	171	38	subsequent	subsequent	ADJ
dti-1319	171	39	silencing	silencing	NOUN
dti-1319	171	40	of	of	ADP
dti-1319	171	41	anti	anti	ADJ
dti-1319	171	42	-	-	ADJ
dti-1319	171	43	apoptotic	apoptotic	ADJ
dti-1319	171	44	gene	gene	NOUN
dti-1319	171	45	expression	expression	NOUN
dti-1319	171	46	.	.	PUNCT
dti-1319	172	1	the	the	DET
dti-1319	172	2	chimeric	chimeric	ADJ
dti-1319	172	3	prna	prna	PROPN
dti-1319	172	4	complex	complex	NOUN
dti-1319	172	5	was	be	AUX
dti-1319	172	6	found	find	VERB
dti-1319	172	7	to	to	PART
dti-1319	172	8	be	be	AUX
dti-1319	172	9	processed	process	VERB
dti-1319	172	10	into	into	ADP
dti-1319	172	11	functional	functional	ADJ
dti-1319	172	12	double	double	ADJ
dti-1319	172	13	-	-	PUNCT
dti-1319	172	14	stranded	strand	VERB
dti-1319	172	15	sirna	sirna	NOUN
dti-1319	172	16	by	by	ADP
dti-1319	172	17	the	the	DET
dti-1319	172	18	rna	rna	PROPN
dti-1319	172	19	-	-	PUNCT
dti-1319	172	20	specifi	specifi	PROPN
dti-1319	172	21	c	c	PROPN
dti-1319	172	22	endonuclease	endonuclease	NOUN
dti-1319	172	23	dicer	dicer	NOUN
dti-1319	172	24	.	.	PUNCT
dti-1319	173	1	animal	animal	NOUN
dti-1319	173	2	trials	trial	NOUN
dti-1319	173	3	confi	confi	VERB
dti-1319	173	4	rmed	rme	VERB
dti-1319	173	5	the	the	DET
dti-1319	173	6	suppression	suppression	NOUN
dti-1319	173	7	of	of	ADP
dti-1319	173	8	tumorigenicity	tumorigenicity	NOUN
dti-1319	173	9	of	of	ADP
dti-1319	173	10	cancer	cancer	NOUN
dti-1319	173	11	cells	cell	NOUN
dti-1319	173	12	by	by	ADP
dti-1319	173	13	ex	ex	PRON
dti-1319	173	14	vivo	vivo	NOUN
dti-1319	173	15	delivery	delivery	NOUN
dti-1319	173	16	(	(	PUNCT
dti-1319	173	17	guo	guo	PROPN
dti-1319	173	18	et	et	PROPN
dti-1319	173	19	al	al	PROPN
dti-1319	173	20	.	.	PROPN
dti-1319	173	21	2005	2005	NUM
dti-1319	173	22	;	;	PUNCT
dti-1319	173	23	khaled	khaled	PROPN
dti-1319	173	24	et	et	PROPN
dti-1319	173	25	al	al	PROPN
dti-1319	173	26	.	.	PROPN
dti-1319	173	27	2005	2005	NUM
dti-1319	173	28	)	)	PUNCT
dti-1319	173	29	.	.	PUNCT
dti-1319	174	1	these	these	DET
dti-1319	174	2	small	small	ADJ
dti-1319	174	3	-	-	PUNCT
dti-1319	174	4	size	size	NOUN
dti-1319	174	5	rna	rna	NOUN
dti-1319	174	6	nanoparticles	nanoparticle	NOUN
dti-1319	174	7	will	will	AUX
dti-1319	174	8	allow	allow	VERB
dti-1319	174	9	repeated	repeat	VERB
dti-1319	174	10	long	long	ADJ
dti-1319	174	11	-	-	PUNCT
dti-1319	174	12	term	term	NOUN
dti-1319	174	13	administration	administration	NOUN
dti-1319	174	14	and	and	CCONJ
dti-1319	174	15	avoid	avoid	VERB
dti-1319	174	16	the	the	DET
dti-1319	174	17	problems	problem	NOUN
dti-1319	174	18	of	of	ADP
dti-1319	174	19	short	short	ADJ
dti-1319	174	20	retention	retention	NOUN
dti-1319	174	21	time	time	NOUN
dti-1319	174	22	of	of	ADP
dti-1319	174	23	small	small	ADJ
dti-1319	174	24	molecules	molecule	NOUN
dti-1319	174	25	and	and	CCONJ
dti-1319	174	26	will	will	AUX
dti-1319	174	27	also	also	ADV
dti-1319	174	28	190	190	NUM
dti-1319	174	29	ulrich	ulrich	PROPN
dti-1319	174	30	et	et	PROPN
dti-1319	174	31	al	al	PROPN
dti-1319	174	32	drug	drug	PROPN
dti-1319	174	33	target	target	NOUN
dti-1319	174	34	insights	insight	NOUN
dti-1319	174	35	2007:2	2007:2	NUM
dti-1319	174	36	avoid	avoid	VERB
dti-1319	174	37	the	the	DET
dti-1319	174	38	delivery	delivery	NOUN
dti-1319	174	39	problems	problem	NOUN
dti-1319	174	40	of	of	ADP
dti-1319	174	41	particles	particle	NOUN
dti-1319	174	42	larger	large	ADJ
dti-1319	174	43	than	than	ADP
dti-1319	174	44	100	100	NUM
dti-1319	174	45	nm	nm	NOUN
dti-1319	174	46	.	.	PUNCT
dti-1319	175	1	farokhzad	farokhzad	PROPN
dti-1319	175	2	and	and	CCONJ
dti-1319	175	3	collaborators	collaborator	NOUN
dti-1319	175	4	(	(	PUNCT
dti-1319	175	5	2004	2004	NUM
dti-1319	175	6	)	)	PUNCT
dti-1319	175	7	synthesized	synthesize	VERB
dti-1319	175	8	a	a	DET
dti-1319	175	9	polylactic	polylactic	ADJ
dti-1319	175	10	acid	acid	NOUN
dti-1319	175	11	(	(	PUNCT
dti-1319	175	12	pla)-block	pla)-block	NOUN
dti-1319	175	13	-	-	PUNCT
dti-1319	175	14	polyethylene	polyethylene	NOUN
dti-1319	175	15	glycol	glycol	NOUN
dti-1319	175	16	(	(	PUNCT
dti-1319	175	17	peg	peg	NOUN
dti-1319	175	18	)	)	PUNCT
dti-1319	175	19	copolymer	copolymer	NOUN
dti-1319	175	20	with	with	ADP
dti-1319	175	21	a	a	DET
dti-1319	175	22	carboxilic	carboxilic	ADJ
dti-1319	175	23	terminal	terminal	ADJ
dti-1319	175	24	functional	functional	ADJ
dti-1319	175	25	group	group	NOUN
dti-1319	175	26	(	(	PUNCT
dti-1319	175	27	pla	pla	NOUN
dti-1319	175	28	-	-	PUNCT
dti-1319	175	29	peg	peg	NOUN
dti-1319	175	30	-	-	PUNCT
dti-1319	175	31	cooh	cooh	NOUN
dti-1319	175	32	)	)	PUNCT
dti-1319	175	33	,	,	PUNCT
dti-1319	175	34	and	and	CCONJ
dti-1319	175	35	encapsulated	encapsulate	VERB
dti-1319	175	36	rhodamine	rhodamine	NOUN
dti-1319	175	37	-	-	PUNCT
dti-1319	175	38	labeled	label	VERB
dti-1319	175	39	dextran	dextran	NOUN
dti-1319	175	40	inside	inside	ADP
dti-1319	175	41	pla	pla	NOUN
dti-1319	175	42	-	-	PUNCT
dti-1319	175	43	peg	peg	NOUN
dti-1319	175	44	-	-	PUNCT
dti-1319	175	45	cooh	cooh	NOUN
dti-1319	175	46	nanoparticles	nanoparticle	NOUN
dti-1319	175	47	.	.	PUNCT
dti-1319	176	1	these	these	DET
dti-1319	176	2	nanoparticles	nanoparticle	NOUN
dti-1319	176	3	have	have	AUX
dti-1319	176	4	negatively	negatively	ADV
dti-1319	176	5	charged	charge	VERB
dti-1319	176	6	carboxilic	carboxilic	ADJ
dti-1319	176	7	groups	group	NOUN
dti-1319	176	8	on	on	ADP
dti-1319	176	9	their	their	PRON
dti-1319	176	10	surfaces	surface	NOUN
dti-1319	176	11	,	,	PUNCT
dti-1319	176	12	which	which	PRON
dti-1319	176	13	minimize	minimize	VERB
dti-1319	176	14	unspecifi	unspecifi	NOUN
dti-1319	176	15	c	c	NOUN
dti-1319	176	16	interactions	interaction	NOUN
dti-1319	176	17	with	with	ADP
dti-1319	176	18	negatively	negatively	ADV
dti-1319	176	19	charged	charge	VERB
dti-1319	176	20	nas	nas	NOUN
dti-1319	176	21	and	and	CCONJ
dti-1319	176	22	,	,	PUNCT
dti-1319	176	23	for	for	ADP
dti-1319	176	24	instance	instance	NOUN
dti-1319	176	25	,	,	PUNCT
dti-1319	176	26	can	can	AUX
dti-1319	176	27	be	be	AUX
dti-1319	176	28	conjugated	conjugate	VERB
dti-1319	176	29	with	with	ADP
dti-1319	176	30	aminomodifi	aminomodifi	NOUN
dti-1319	176	31	ed	ed	PROPN
dti-1319	176	32	nas	nas	PROPN
dti-1319	176	33	.	.	PUNCT
dti-1319	177	1	clinical	clinical	ADJ
dti-1319	177	2	trials	trial	NOUN
dti-1319	177	3	revealed	reveal	VERB
dti-1319	177	4	that	that	SCONJ
dti-1319	177	5	the	the	DET
dti-1319	177	6	presence	presence	NOUN
dti-1319	177	7	of	of	ADP
dti-1319	177	8	anti	anti	ADJ
dti-1319	177	9	-	-	ADJ
dti-1319	177	10	psma	psma	ADJ
dti-1319	177	11	aptamers	aptamer	NOUN
dti-1319	177	12	at	at	ADP
dti-1319	177	13	target	target	NOUN
dti-1319	177	14	cells	cell	NOUN
dti-1319	177	15	is	be	AUX
dti-1319	177	16	increased	increase	VERB
dti-1319	177	17	77	77	NUM
dti-1319	177	18	-	-	NOUN
dti-1319	177	19	fold	fold	ADJ
dti-1319	177	20	when	when	SCONJ
dti-1319	177	21	it	it	PRON
dti-1319	177	22	is	be	AUX
dti-1319	177	23	bioconjugated	bioconjugate	VERB
dti-1319	177	24	to	to	ADP
dti-1319	177	25	a	a	DET
dti-1319	177	26	nanoparticle	nanoparticle	NOUN
dti-1319	177	27	(	(	PUNCT
dti-1319	177	28	farokhzad	farokhzad	ADV
dti-1319	177	29	et	et	PROPN
dti-1319	177	30	al	al	PROPN
dti-1319	177	31	.	.	PROPN
dti-1319	177	32	2004	2004	NUM
dti-1319	177	33	)	)	PUNCT
dti-1319	177	34	.	.	PUNCT
dti-1319	178	1	the	the	DET
dti-1319	178	2	incubation	incubation	NOUN
dti-1319	178	3	of	of	ADP
dti-1319	178	4	protein	protein	NOUN
dti-1319	178	5	-	-	PUNCT
dti-1319	178	6	free	free	ADJ
dti-1319	178	7	nanoscale	nanoscale	NOUN
dti-1319	178	8	particles	particle	NOUN
dti-1319	178	9	containing	contain	VERB
dti-1319	178	10	a	a	DET
dti-1319	178	11	receptor	receptor	NOUN
dti-1319	178	12	-	-	PUNCT
dti-1319	178	13	binding	bind	VERB
dti-1319	178	14	aptamer	aptamer	NOUN
dti-1319	178	15	or	or	CCONJ
dti-1319	178	16	other	other	ADJ
dti-1319	178	17	ligands	ligand	NOUN
dti-1319	178	18	may	may	AUX
dti-1319	178	19	result	result	VERB
dti-1319	178	20	in	in	ADP
dti-1319	178	21	the	the	DET
dti-1319	178	22	binding	bind	VERB
dti-1319	178	23	and	and	CCONJ
dti-1319	178	24	internalization	internalization	NOUN
dti-1319	178	25	of	of	ADP
dti-1319	178	26	the	the	DET
dti-1319	178	27	trivalent	trivalent	NOUN
dti-1319	178	28	therapeutic	therapeutic	ADJ
dti-1319	178	29	particles	particle	NOUN
dti-1319	178	30	(	(	PUNCT
dti-1319	178	31	dtxl	dtxl	NOUN
dti-1319	178	32	-	-	PUNCT
dti-1319	178	33	np	np	ADV
dti-1319	178	34	-	-	PUNCT
dti-1319	178	35	apt	apt	ADJ
dti-1319	178	36	or	or	CCONJ
dti-1319	178	37	pla	pla	NOUN
dti-1319	178	38	-	-	PUNCT
dti-1319	178	39	peg	peg	NOUN
dti-1319	178	40	-	-	PUNCT
dti-1319	178	41	cooh	cooh	NOUN
dti-1319	178	42	-	-	PUNCT
dti-1319	178	43	apt	apt	ADJ
dti-1319	178	44	)	)	PUNCT
dti-1319	178	45	subsequently	subsequently	ADV
dti-1319	178	46	modulating	modulate	VERB
dti-1319	178	47	prostate	prostate	NOUN
dti-1319	178	48	cancer	cancer	NOUN
dti-1319	178	49	cell	cell	NOUN
dti-1319	178	50	apoptosis	apoptosis	NOUN
dti-1319	178	51	.	.	PUNCT
dti-1319	179	1	these	these	DET
dti-1319	179	2	bioconjugates	bioconjugate	NOUN
dti-1319	179	3	were	be	AUX
dti-1319	179	4	based	base	VERB
dti-1319	179	5	on	on	ADP
dti-1319	179	6	materials	material	NOUN
dti-1319	179	7	which	which	PRON
dti-1319	179	8	had	have	AUX
dti-1319	179	9	been	be	AUX
dti-1319	179	10	priorly	priorly	ADV
dti-1319	179	11	approved	approve	VERB
dti-1319	179	12	for	for	ADP
dti-1319	179	13	clinical	clinical	ADJ
dti-1319	179	14	use	use	NOUN
dti-1319	179	15	by	by	ADP
dti-1319	179	16	the	the	DET
dti-1319	179	17	fda	fda	PROPN
dti-1319	179	18	.	.	PUNCT
dti-1319	180	1	since	since	SCONJ
dti-1319	180	2	these	these	DET
dti-1319	180	3	molecules	molecule	NOUN
dti-1319	180	4	are	be	AUX
dti-1319	180	5	small	small	ADJ
dti-1319	180	6	,	,	PUNCT
dti-1319	180	7	relatively	relatively	ADV
dti-1319	180	8	stable	stable	ADJ
dti-1319	180	9	,	,	PUNCT
dti-1319	180	10	non	non	ADJ
dti-1319	180	11	-	-	ADJ
dti-1319	180	12	immunogenic	immunogenic	ADJ
dti-1319	180	13	and	and	CCONJ
dti-1319	180	14	easy	easy	ADJ
dti-1319	180	15	to	to	PART
dti-1319	180	16	synthesize	synthesize	VERB
dti-1319	180	17	,	,	PUNCT
dti-1319	180	18	the	the	DET
dti-1319	180	19	translation	translation	NOUN
dti-1319	180	20	of	of	ADP
dti-1319	180	21	these	these	DET
dti-1319	180	22	bioconjugates	bioconjugate	NOUN
dti-1319	180	23	into	into	ADP
dti-1319	180	24	clinical	clinical	ADJ
dti-1319	180	25	practice	practice	NOUN
dti-1319	180	26	is	be	AUX
dti-1319	180	27	facilitated	facilitate	VERB
dti-1319	180	28	.	.	PUNCT
dti-1319	181	1	therefore	therefore	ADV
dti-1319	181	2	,	,	PUNCT
dti-1319	181	3	therapeutic	therapeutic	ADJ
dti-1319	181	4	and	and	CCONJ
dti-1319	181	5	diagnostic	diagnostic	ADJ
dti-1319	181	6	nanoparticle	nanoparticle	NOUN
dti-1319	181	7	-	-	PUNCT
dti-1319	181	8	aptamer	aptamer	NOUN
dti-1319	181	9	bioconjugates	bioconjugate	NOUN
dti-1319	181	10	will	will	AUX
dti-1319	181	11	be	be	AUX
dti-1319	181	12	shortly	shortly	ADV
dti-1319	181	13	developed	develop	VERB
dti-1319	181	14	for	for	ADP
dti-1319	181	15	other	other	ADJ
dti-1319	181	16	important	important	ADJ
dti-1319	181	17	human	human	ADJ
dti-1319	181	18	diseases	disease	NOUN
dti-1319	181	19	.	.	PUNCT
dti-1319	182	1	in	in	ADP
dti-1319	182	2	this	this	DET
dti-1319	182	3	regard	regard	NOUN
dti-1319	182	4	,	,	PUNCT
dti-1319	182	5	rna	rna	NOUN
dti-1319	182	6	molecules	molecule	NOUN
dti-1319	182	7	might	might	AUX
dti-1319	182	8	be	be	AUX
dti-1319	182	9	used	use	VERB
dti-1319	182	10	as	as	ADP
dti-1319	182	11	building	build	VERB
dti-1319	182	12	blocks	block	NOUN
dti-1319	182	13	in	in	ADP
dti-1319	182	14	many	many	ADJ
dti-1319	182	15	associations	association	NOUN
dti-1319	182	16	in	in	ADP
dti-1319	182	17	nanotechnology	nanotechnology	NOUN
dti-1319	182	18	.	.	PUNCT
dti-1319	183	1	the	the	DET
dti-1319	183	2	delivery	delivery	NOUN
dti-1319	183	3	of	of	ADP
dti-1319	183	4	macromolecules	macromolecule	NOUN
dti-1319	183	5	(	(	PUNCT
dti-1319	183	6	including	include	VERB
dti-1319	183	7	globular	globular	ADJ
dti-1319	183	8	proteins	protein	NOUN
dti-1319	183	9	and	and	CCONJ
dti-1319	183	10	aptamers	aptamer	NOUN
dti-1319	183	11	)	)	PUNCT
dti-1319	183	12	to	to	ADP
dti-1319	183	13	the	the	DET
dti-1319	183	14	sclera	sclera	NOUN
dti-1319	183	15	as	as	ADP
dti-1319	183	16	therapeutics	therapeutic	NOUN
dti-1319	183	17	in	in	ADP
dti-1319	183	18	eye	eye	NOUN
dti-1319	183	19	disease	disease	NOUN
dti-1319	183	20	has	have	AUX
dti-1319	183	21	been	be	AUX
dti-1319	183	22	described	describe	VERB
dti-1319	183	23	in	in	ADP
dti-1319	183	24	recent	recent	ADJ
dti-1319	183	25	studies	study	NOUN
dti-1319	183	26	(	(	PUNCT
dti-1319	183	27	ambati	ambati	PROPN
dti-1319	183	28	et	et	PROPN
dti-1319	183	29	al	al	PROPN
dti-1319	183	30	.	.	PROPN
dti-1319	183	31	2000a	2000a	NOUN
dti-1319	183	32	;	;	PUNCT
dti-1319	183	33	ambati	ambati	PROPN
dti-1319	183	34	et	et	PROPN
dti-1319	183	35	al	al	PROPN
dti-1319	183	36	.	.	PROPN
dti-1319	183	37	2000b	2000b	NUM
dti-1319	183	38	)	)	PUNCT
dti-1319	183	39	.	.	PUNCT
dti-1319	184	1	the	the	DET
dti-1319	184	2	transport	transport	NOUN
dti-1319	184	3	and	and	CCONJ
dti-1319	184	4	potential	potential	ADJ
dti-1319	184	5	diffusion	diffusion	NOUN
dti-1319	184	6	of	of	ADP
dti-1319	184	7	molecules	molecule	NOUN
dti-1319	184	8	to	to	ADP
dti-1319	184	9	the	the	DET
dti-1319	184	10	sclera	sclera	NOUN
dti-1319	184	11	takes	take	VERB
dti-1319	184	12	place	place	NOUN
dti-1319	184	13	through	through	ADP
dti-1319	184	14	an	an	DET
dti-1319	184	15	extensive	extensive	ADJ
dti-1319	184	16	surface	surface	NOUN
dti-1319	184	17	area	area	NOUN
dti-1319	184	18	containing	contain	VERB
dti-1319	184	19	a	a	DET
dti-1319	184	20	high	high	ADJ
dti-1319	184	21	percentage	percentage	NOUN
dti-1319	184	22	of	of	ADP
dti-1319	184	23	water	water	NOUN
dti-1319	184	24	.	.	PUNCT
dti-1319	185	1	water	water	NOUN
dti-1319	185	2	is	be	AUX
dti-1319	185	3	the	the	DET
dti-1319	185	4	main	main	ADJ
dti-1319	185	5	constituent	constituent	NOUN
dti-1319	185	6	of	of	ADP
dti-1319	185	7	the	the	DET
dti-1319	185	8	extracellular	extracellular	ADJ
dti-1319	185	9	matrix	matrix	NOUN
dti-1319	185	10	containing	contain	VERB
dti-1319	185	11	few	few	ADJ
dti-1319	185	12	cells	cell	NOUN
dti-1319	185	13	and	and	CCONJ
dti-1319	185	14	unchanging	unchanging	ADJ
dti-1319	185	15	permeability	permeability	NOUN
dti-1319	185	16	during	during	ADP
dti-1319	185	17	aging	age	VERB
dti-1319	185	18	(	(	PUNCT
dti-1319	185	19	olsen	olsen	NOUN
dti-1319	185	20	et	et	PROPN
dti-1319	185	21	al	al	PROPN
dti-1319	185	22	.	.	PROPN
dti-1319	185	23	1998	1998	NUM
dti-1319	185	24	;	;	PUNCT
dti-1319	185	25	olsen	olsen	NOUN
dti-1319	185	26	et	et	PROPN
dti-1319	185	27	al	al	PROPN
dti-1319	185	28	.	.	PROPN
dti-1319	185	29	1995	1995	NUM
dti-1319	185	30	;	;	PUNCT
dti-1319	185	31	boubriak	boubriak	PROPN
dti-1319	185	32	et	et	PROPN
dti-1319	185	33	al	al	PROPN
dti-1319	185	34	.	.	PROPN
dti-1319	185	35	2000	2000	NUM
dti-1319	185	36	)	)	PUNCT
dti-1319	185	37	.	.	PUNCT
dti-1319	186	1	the	the	DET
dti-1319	186	2	use	use	NOUN
dti-1319	186	3	of	of	ADP
dti-1319	186	4	this	this	DET
dti-1319	186	5	route	route	NOUN
dti-1319	186	6	of	of	ADP
dti-1319	186	7	administration	administration	NOUN
dti-1319	186	8	could	could	AUX
dti-1319	186	9	avoid	avoid	VERB
dti-1319	186	10	problems	problem	NOUN
dti-1319	186	11	and	and	CCONJ
dti-1319	186	12	limitations	limitation	NOUN
dti-1319	186	13	of	of	ADP
dti-1319	186	14	other	other	ADJ
dti-1319	186	15	delivery	delivery	NOUN
dti-1319	186	16	approaches	approach	NOUN
dti-1319	186	17	in	in	ADP
dti-1319	186	18	the	the	DET
dti-1319	186	19	treatment	treatment	NOUN
dti-1319	186	20	of	of	ADP
dti-1319	186	21	viral	viral	ADJ
dti-1319	186	22	and	and	CCONJ
dti-1319	186	23	systemic	systemic	ADJ
dti-1319	186	24	diseases	disease	NOUN
dti-1319	186	25	(	(	PUNCT
dti-1319	186	26	kamei	kamei	PROPN
dti-1319	186	27	et	et	PROPN
dti-1319	186	28	al	al	PROPN
dti-1319	186	29	.	.	PROPN
dti-1319	186	30	1999	1999	NUM
dti-1319	186	31	;	;	PUNCT
dti-1319	186	32	dayle	dayle	PROPN
dti-1319	186	33	,	,	PUNCT
dti-1319	186	34	2001	2001	NUM
dti-1319	186	35	;	;	PUNCT
dti-1319	186	36	lang	lang	PROPN
dti-1319	186	37	,	,	PUNCT
dti-1319	186	38	1995	1995	NUM
dti-1319	186	39	)	)	PUNCT
dti-1319	186	40	.	.	PUNCT
dti-1319	187	1	since	since	SCONJ
dti-1319	187	2	some	some	DET
dti-1319	187	3	transscleral	transscleral	ADJ
dti-1319	187	4	delivery	delivery	NOUN
dti-1319	187	5	systems	system	NOUN
dti-1319	187	6	may	may	AUX
dti-1319	187	7	be	be	AUX
dti-1319	187	8	destructive	destructive	ADJ
dti-1319	187	9	(	(	PUNCT
dti-1319	187	10	i.e.	i.e.	X
dti-1319	187	11	iontophoresis	iontophoresis	NOUN
dti-1319	187	12	)	)	PUNCT
dti-1319	187	13	occasionally	occasionally	ADV
dti-1319	187	14	provoking	provoke	VERB
dti-1319	187	15	retinal	retinal	ADJ
dti-1319	187	16	necrosis	necrosis	NOUN
dti-1319	187	17	and	and	CCONJ
dti-1319	187	18	gliosis	gliosis	NOUN
dti-1319	187	19	(	(	PUNCT
dti-1319	187	20	lam	lam	PROPN
dti-1319	187	21	et	et	PROPN
dti-1319	187	22	al	al	PROPN
dti-1319	187	23	.	.	PROPN
dti-1319	187	24	1991	1991	NUM
dti-1319	187	25	)	)	PUNCT
dti-1319	187	26	,	,	PUNCT
dti-1319	187	27	the	the	DET
dti-1319	187	28	ideal	ideal	ADJ
dti-1319	187	29	approach	approach	NOUN
dti-1319	187	30	would	would	AUX
dti-1319	187	31	be	be	AUX
dti-1319	187	32	to	to	PART
dti-1319	187	33	develop	develop	VERB
dti-1319	187	34	biodegradable	biodegradable	ADJ
dti-1319	187	35	polimeric	polimeric	ADJ
dti-1319	187	36	particles	particle	NOUN
dti-1319	187	37	with	with	ADP
dti-1319	187	38	prolonged	prolonged	ADJ
dti-1319	187	39	delivery	delivery	NOUN
dti-1319	187	40	capacity	capacity	NOUN
dti-1319	187	41	.	.	PUNCT
dti-1319	188	1	lenghtened	lenghtene	VERB
dti-1319	188	2	protein	protein	NOUN
dti-1319	188	3	and	and	CCONJ
dti-1319	188	4	na	na	PART
dti-1319	188	5	release	release	VERB
dti-1319	188	6	time	time	NOUN
dti-1319	188	7	-	-	PUNCT
dti-1319	188	8	spans	span	NOUN
dti-1319	188	9	would	would	AUX
dti-1319	188	10	allow	allow	VERB
dti-1319	188	11	more	more	ADJ
dti-1319	188	12	effi	effi	PROPN
dti-1319	188	13	cient	cient	NOUN
dti-1319	188	14	addressing	address	VERB
dti-1319	188	15	of	of	ADP
dti-1319	188	16	drugs	drug	NOUN
dti-1319	188	17	to	to	PART
dti-1319	188	18	specifi	specifi	PROPN
dti-1319	188	19	c	c	PROPN
dti-1319	188	20	target	target	NOUN
dti-1319	188	21	tissues	tissue	NOUN
dti-1319	188	22	(	(	PUNCT
dti-1319	188	23	carrasquillo	carrasquillo	VERB
dti-1319	188	24	et	et	PROPN
dti-1319	188	25	al	al	PROPN
dti-1319	188	26	.	.	PROPN
dti-1319	188	27	1999	1999	NUM
dti-1319	188	28	;	;	PUNCT
dti-1319	188	29	carrasquillo	carrasquillo	VERB
dti-1319	188	30	et	et	PROPN
dti-1319	188	31	al	al	PROPN
dti-1319	188	32	.	.	PROPN
dti-1319	188	33	2001a	2001a	NUM
dti-1319	188	34	;	;	PUNCT
dti-1319	188	35	carrasquillo	carrasquillo	PROPN
dti-1319	188	36	et	et	PROPN
dti-1319	188	37	al	al	PROPN
dti-1319	188	38	.	.	PROPN
dti-1319	188	39	2001b	2001b	NUM
dti-1319	188	40	)	)	PUNCT
dti-1319	188	41	.	.	PUNCT
dti-1319	189	1	frazza	frazza	PROPN
dti-1319	189	2	and	and	CCONJ
dti-1319	189	3	schmitt	schmitt	PROPN
dti-1319	189	4	(	(	PUNCT
dti-1319	189	5	1971	1971	NUM
dti-1319	189	6	)	)	PUNCT
dti-1319	189	7	developed	develop	VERB
dti-1319	189	8	a	a	DET
dti-1319	189	9	poly	poly	ADJ
dti-1319	189	10	(	(	PUNCT
dti-1319	189	11	lactic	lactic	NOUN
dti-1319	189	12	-	-	PUNCT
dti-1319	189	13	co	co	NOUN
dti-1319	189	14	-	-	NOUN
dti-1319	189	15	glycolic	glycolic	ADJ
dti-1319	189	16	)	)	PUNCT
dti-1319	189	17	acid	acid	NOUN
dti-1319	189	18	(	(	PUNCT
dti-1319	189	19	plga	plga	NOUN
dti-1319	189	20	)	)	PUNCT
dti-1319	189	21	polymer	polymer	NOUN
dti-1319	189	22	,	,	PUNCT
dti-1319	189	23	which	which	PRON
dti-1319	189	24	since	since	SCONJ
dti-1319	189	25	then	then	ADV
dti-1319	189	26	has	have	AUX
dti-1319	189	27	been	be	AUX
dti-1319	189	28	widely	widely	ADV
dti-1319	189	29	used	use	VERB
dti-1319	189	30	in	in	ADP
dti-1319	189	31	clinical	clinical	ADJ
dti-1319	189	32	procedures	procedure	NOUN
dti-1319	189	33	as	as	ADP
dti-1319	189	34	suture	suture	NOUN
dti-1319	189	35	for	for	ADP
dti-1319	189	36	tissue	tissue	NOUN
dti-1319	189	37	engineering	engineering	NOUN
dti-1319	189	38	(	(	PUNCT
dti-1319	189	39	hasirci	hasirci	NOUN
dti-1319	189	40	et	et	PROPN
dti-1319	189	41	al	al	PROPN
dti-1319	189	42	.	.	PROPN
dti-1319	189	43	2001	2001	NUM
dti-1319	189	44	;	;	PUNCT
dti-1319	189	45	ma	ma	PROPN
dti-1319	189	46	and	and	CCONJ
dti-1319	189	47	choi	choi	NOUN
dti-1319	189	48	,	,	PUNCT
dti-1319	189	49	2001	2001	NUM
dti-1319	189	50	)	)	PUNCT
dti-1319	189	51	.	.	PUNCT
dti-1319	190	1	plga	plga	NOUN
dti-1319	190	2	may	may	AUX
dti-1319	190	3	be	be	AUX
dti-1319	190	4	locally	locally	ADV
dti-1319	190	5	applied	apply	VERB
dti-1319	190	6	,	,	PUNCT
dti-1319	190	7	allowing	allow	VERB
dti-1319	190	8	intralesional	intralesional	ADJ
dti-1319	190	9	administration	administration	NOUN
dti-1319	190	10	of	of	ADP
dti-1319	190	11	drugs	drug	NOUN
dti-1319	190	12	while	while	SCONJ
dti-1319	190	13	minimizing	minimize	VERB
dti-1319	190	14	adverse	adverse	ADJ
dti-1319	190	15	systemic	systemic	ADJ
dti-1319	190	16	effects	effect	NOUN
dti-1319	190	17	.	.	PUNCT
dti-1319	191	1	the	the	DET
dti-1319	191	2	possibility	possibility	NOUN
dti-1319	191	3	of	of	ADP
dti-1319	191	4	local	local	ADJ
dti-1319	191	5	application	application	NOUN
dti-1319	191	6	of	of	ADP
dti-1319	191	7	plga	plga	NOUN
dti-1319	191	8	constitutes	constitute	VERB
dti-1319	191	9	an	an	DET
dti-1319	191	10	important	important	ADJ
dti-1319	191	11	pharmacological	pharmacological	ADJ
dti-1319	191	12	advantage	advantage	NOUN
dti-1319	191	13	(	(	PUNCT
dti-1319	191	14	mallery	mallery	NOUN
dti-1319	191	15	et	et	PROPN
dti-1319	191	16	al	al	PROPN
dti-1319	191	17	.	.	PROPN
dti-1319	191	18	2000	2000	NUM
dti-1319	191	19	;	;	PUNCT
dti-1319	191	20	moritera	moritera	NOUN
dti-1319	191	21	et	et	PROPN
dti-1319	191	22	al	al	PROPN
dti-1319	191	23	.	.	PROPN
dti-1319	191	24	1991	1991	NUM
dti-1319	191	25	)	)	PUNCT
dti-1319	191	26	.	.	PUNCT
dti-1319	192	1	the	the	DET
dti-1319	192	2	employment	employment	NOUN
dti-1319	192	3	of	of	ADP
dti-1319	192	4	plga	plga	NOUN
dti-1319	192	5	as	as	ADP
dti-1319	192	6	a	a	DET
dti-1319	192	7	drug	drug	NOUN
dti-1319	192	8	delivery	delivery	NOUN
dti-1319	192	9	system	system	NOUN
dti-1319	192	10	for	for	ADP
dti-1319	192	11	the	the	DET
dti-1319	192	12	therapy	therapy	NOUN
dti-1319	192	13	of	of	ADP
dti-1319	192	14	ocular	ocular	ADJ
dti-1319	192	15	diseases	disease	NOUN
dti-1319	192	16	did	do	AUX
dti-1319	192	17	not	not	PART
dti-1319	192	18	reveal	reveal	VERB
dti-1319	192	19	any	any	DET
dti-1319	192	20	signs	sign	NOUN
dti-1319	192	21	of	of	ADP
dti-1319	192	22	ocular	ocular	ADJ
dti-1319	192	23	toxicity	toxicity	NOUN
dti-1319	192	24	or	or	CCONJ
dti-1319	192	25	infl	infl	NOUN
dti-1319	192	26	ammatory	ammatory	NOUN
dti-1319	192	27	processes	process	NOUN
dti-1319	192	28	even	even	ADV
dti-1319	192	29	during	during	ADP
dti-1319	192	30	long	long	ADJ
dti-1319	192	31	treatment	treatment	NOUN
dti-1319	192	32	periods	period	NOUN
dti-1319	192	33	(	(	PUNCT
dti-1319	192	34	moritera	moritera	NOUN
dti-1319	192	35	et	et	PROPN
dti-1319	192	36	al	al	PROPN
dti-1319	192	37	.	.	PROPN
dti-1319	192	38	1991	1991	NUM
dti-1319	192	39	;	;	PUNCT
dti-1319	192	40	giordano	giordano	PROPN
dti-1319	192	41	et	et	PROPN
dti-1319	192	42	al	al	PROPN
dti-1319	192	43	.	.	PROPN
dti-1319	192	44	1995	1995	NUM
dti-1319	192	45	)	)	PUNCT
dti-1319	192	46	.	.	PUNCT
dti-1319	193	1	however	however	ADV
dti-1319	193	2	,	,	PUNCT
dti-1319	193	3	adverse	adverse	ADJ
dti-1319	193	4	side	side	NOUN
dti-1319	193	5	effects	effect	NOUN
dti-1319	193	6	resulted	result	VERB
dti-1319	193	7	from	from	ADP
dti-1319	193	8	the	the	DET
dti-1319	193	9	sclerotomy	sclerotomy	NOUN
dti-1319	193	10	as	as	ADP
dti-1319	193	11	result	result	NOUN
dti-1319	193	12	of	of	ADP
dti-1319	193	13	the	the	DET
dti-1319	193	14	delivery	delivery	NOUN
dti-1319	193	15	procedure	procedure	NOUN
dti-1319	193	16	of	of	ADP
dti-1319	193	17	small	small	ADJ
dti-1319	193	18	encapsulated	encapsulate	VERB
dti-1319	193	19	synthetic	synthetic	ADJ
dti-1319	193	20	drugs	drug	NOUN
dti-1319	193	21	.	.	PUNCT
dti-1319	194	1	carrasquillo	carrasquillo	VERB
dti-1319	194	2	et	et	PROPN
dti-1319	194	3	al	al	PROPN
dti-1319	194	4	.	.	PROPN
dti-1319	195	1	(	(	PUNCT
dti-1319	195	2	2003	2003	NUM
dti-1319	195	3	)	)	PUNCT
dti-1319	195	4	developed	develop	VERB
dti-1319	195	5	a	a	DET
dti-1319	195	6	drug	drug	NOUN
dti-1319	195	7	delivery	delivery	NOUN
dti-1319	195	8	system	system	NOUN
dti-1319	195	9	that	that	PRON
dti-1319	195	10	continuously	continuously	ADV
dti-1319	195	11	releases	release	VERB
dti-1319	195	12	the	the	DET
dti-1319	195	13	eye001	eye001	PROPN
dti-1319	195	14	anti	anti	ADJ
dti-1319	195	15	-	-	ADJ
dti-1319	195	16	vegf	vegf	ADJ
dti-1319	195	17	aptamer	aptamer	NOUN
dti-1319	195	18	(	(	PUNCT
dti-1319	195	19	macugen	macugen	PROPN
dti-1319	195	20	)	)	PUNCT
dti-1319	195	21	in	in	ADP
dti-1319	195	22	a	a	DET
dti-1319	195	23	controlled	control	VERB
dti-1319	195	24	fashion	fashion	NOUN
dti-1319	195	25	during	during	ADP
dti-1319	195	26	signifi	signifi	NOUN
dti-1319	195	27	ca	can	AUX
dti-1319	195	28	nt	not	PART
dti-1319	195	29	time	time	VERB
dti-1319	195	30	spans	span	NOUN
dti-1319	195	31	when	when	SCONJ
dti-1319	195	32	it	it	PRON
dti-1319	195	33	is	be	AUX
dti-1319	195	34	locally	locally	ADV
dti-1319	195	35	administered	administer	VERB
dti-1319	195	36	at	at	ADP
dti-1319	195	37	the	the	DET
dti-1319	195	38	external	external	ADJ
dti-1319	195	39	area	area	NOUN
dti-1319	195	40	of	of	ADP
dti-1319	195	41	the	the	DET
dti-1319	195	42	sclera	sclera	NOUN
dti-1319	195	43	.	.	PUNCT
dti-1319	196	1	the	the	DET
dti-1319	196	2	use	use	NOUN
dti-1319	196	3	of	of	ADP
dti-1319	196	4	the	the	DET
dti-1319	196	5	proposed	propose	VERB
dti-1319	196	6	delivery	delivery	NOUN
dti-1319	196	7	system	system	NOUN
dti-1319	196	8	for	for	ADP
dti-1319	196	9	the	the	DET
dti-1319	196	10	release	release	NOUN
dti-1319	196	11	of	of	ADP
dti-1319	196	12	macugen	macugen	PROPN
dti-1319	196	13	illustrates	illustrate	VERB
dti-1319	196	14	a	a	DET
dti-1319	196	15	promissing	promisse	VERB
dti-1319	196	16	alternative	alternative	NOUN
dti-1319	196	17	for	for	ADP
dti-1319	196	18	the	the	DET
dti-1319	196	19	tansscleral	tansscleral	ADJ
dti-1319	196	20	delivery	delivery	NOUN
dti-1319	196	21	of	of	ADP
dti-1319	196	22	drugs	drug	NOUN
dti-1319	196	23	for	for	ADP
dti-1319	196	24	the	the	DET
dti-1319	196	25	treatment	treatment	NOUN
dti-1319	196	26	of	of	ADP
dti-1319	196	27	ocular	ocular	ADJ
dti-1319	196	28	and	and	CCONJ
dti-1319	196	29	choroidal	choroidal	ADJ
dti-1319	196	30	illnesses	illness	NOUN
dti-1319	196	31	.	.	PUNCT
dti-1319	197	1	another	another	DET
dti-1319	197	2	way	way	NOUN
dti-1319	197	3	to	to	PART
dti-1319	197	4	successfully	successfully	ADV
dti-1319	197	5	home	home	NOUN
dti-1319	197	6	aptamers	aptamer	NOUN
dti-1319	197	7	at	at	ADP
dti-1319	197	8	their	their	PRON
dti-1319	197	9	subcellular	subcellular	ADJ
dti-1319	197	10	targets	target	NOUN
dti-1319	197	11	is	be	AUX
dti-1319	197	12	to	to	PART
dti-1319	197	13	express	express	VERB
dti-1319	197	14	them	they	PRON
dti-1319	197	15	in	in	ADP
dti-1319	197	16	the	the	DET
dti-1319	197	17	cells	cell	NOUN
dti-1319	197	18	of	of	ADP
dti-1319	197	19	interest	interest	NOUN
dti-1319	197	20	.	.	PUNCT
dti-1319	198	1	in	in	ADP
dti-1319	198	2	this	this	DET
dti-1319	198	3	case	case	NOUN
dti-1319	198	4	the	the	DET
dti-1319	198	5	expressed	express	VERB
dti-1319	198	6	drugs	drug	NOUN
dti-1319	198	7	would	would	AUX
dti-1319	198	8	be	be	AUX
dti-1319	198	9	useful	useful	ADJ
dti-1319	198	10	for	for	ADP
dti-1319	198	11	both	both	CCONJ
dti-1319	198	12	the	the	DET
dti-1319	198	13	treatment	treatment	NOUN
dti-1319	198	14	of	of	ADP
dti-1319	198	15	hereditary	hereditary	ADJ
dti-1319	198	16	diseases	disease	NOUN
dti-1319	198	17	as	as	ADV
dti-1319	198	18	well	well	ADV
dti-1319	198	19	as	as	ADP
dti-1319	198	20	of	of	ADP
dti-1319	198	21	viral	viral	ADJ
dti-1319	198	22	diseases	disease	NOUN
dti-1319	198	23	such	such	ADJ
dti-1319	198	24	as	as	ADP
dti-1319	198	25	aids	aid	NOUN
dti-1319	198	26	.	.	PUNCT
dti-1319	199	1	the	the	DET
dti-1319	199	2	tar	tar	NOUN
dti-1319	199	3	region	region	NOUN
dti-1319	199	4	of	of	ADP
dti-1319	199	5	the	the	DET
dti-1319	199	6	rna	rna	NOUN
dti-1319	199	7	genome	genome	NOUN
dti-1319	199	8	of	of	ADP
dti-1319	199	9	hiv-1	hiv-1	PUNCT
dti-1319	199	10	is	be	AUX
dti-1319	199	11	an	an	DET
dti-1319	199	12	attractive	attractive	ADJ
dti-1319	199	13	target	target	NOUN
dti-1319	199	14	for	for	ADP
dti-1319	199	15	inhibitory	inhibitory	ADJ
dti-1319	199	16	nabased	nabased	ADJ
dti-1319	199	17	drugs	drug	NOUN
dti-1319	199	18	.	.	PUNCT
dti-1319	200	1	tar	tar	NOUN
dti-1319	200	2	is	be	AUX
dti-1319	200	3	a	a	DET
dti-1319	200	4	57	57	NUM
dti-1319	200	5	nucleotide	nucleotide	ADJ
dti-1319	200	6	regulatory	regulatory	ADJ
dti-1319	200	7	element	element	NOUN
dti-1319	200	8	present	present	ADJ
dti-1319	200	9	at	at	ADP
dti-1319	200	10	the	the	DET
dti-1319	200	11	5′	5′	NUM
dti-1319	200	12	end	end	NOUN
dti-1319	200	13	of	of	ADP
dti-1319	200	14	every	every	DET
dti-1319	200	15	viral	viral	ADJ
dti-1319	200	16	rna	rna	NOUN
dti-1319	200	17	particle	particle	NOUN
dti-1319	200	18	.	.	PUNCT
dti-1319	201	1	it	it	PRON
dti-1319	201	2	exerts	exert	VERB
dti-1319	201	3	a	a	DET
dti-1319	201	4	crucial	crucial	ADJ
dti-1319	201	5	role	role	NOUN
dti-1319	201	6	on	on	ADP
dti-1319	201	7	viral	viral	ADJ
dti-1319	201	8	transcription	transcription	NOUN
dti-1319	201	9	,	,	PUNCT
dti-1319	201	10	as	as	SCONJ
dti-1319	201	11	it	it	PRON
dti-1319	201	12	is	be	AUX
dti-1319	201	13	recognized	recognize	VERB
dti-1319	201	14	by	by	ADP
dti-1319	201	15	the	the	DET
dti-1319	201	16	ternary	ternary	ADJ
dti-1319	201	17	complex	complex	NOUN
dti-1319	201	18	composed	compose	VERB
dti-1319	201	19	of	of	ADP
dti-1319	201	20	the	the	DET
dti-1319	201	21	tat	tat	ADJ
dti-1319	201	22	viral	viral	ADJ
dti-1319	201	23	protein	protein	NOUN
dti-1319	201	24	(	(	PUNCT
dti-1319	201	25	trans	trans	NOUN
dti-1319	201	26	-	-	NOUN
dti-1319	201	27	activator	activator	NOUN
dti-1319	201	28	of	of	ADP
dti-1319	201	29	transcription	transcription	NOUN
dti-1319	201	30	)	)	PUNCT
dti-1319	201	31	and	and	CCONJ
dti-1319	201	32	of	of	ADP
dti-1319	201	33	two	two	NUM
dti-1319	201	34	cellular	cellular	ADJ
dti-1319	201	35	proteins	protein	NOUN
dti-1319	201	36	named	name	VERB
dti-1319	201	37	cyclin	cyclin	PROPN
dti-1319	201	38	t1	t1	NOUN
dti-1319	201	39	and	and	CCONJ
dti-1319	201	40	cdk9	cdk9	PROPN
dti-1319	201	41	(	(	PUNCT
dti-1319	201	42	herrmann	herrmann	PROPN
dti-1319	201	43	and	and	CCONJ
dti-1319	201	44	mancini	mancini	PROPN
dti-1319	201	45	,	,	PUNCT
dti-1319	201	46	2001	2001	NUM
dti-1319	201	47	;	;	PUNCT
dti-1319	202	1	richter	richter	PROPN
dti-1319	202	2	et	et	PROPN
dti-1319	202	3	al	al	PROPN
dti-1319	202	4	.	.	PROPN
dti-1319	202	5	2002).cdk9	2002).cdk9	NUM
dti-1319	202	6	when	when	SCONJ
dti-1319	202	7	associated	associate	VERB
dti-1319	202	8	to	to	ADP
dti-1319	202	9	tat	tat	NOUN
dti-1319	202	10	,	,	PUNCT
dti-1319	202	11	hyperphosphorilates	hyperphosphorilate	VERB
dti-1319	202	12	the	the	DET
dti-1319	202	13	carboxy	carboxy	ADJ
dti-1319	202	14	-	-	PUNCT
dti-1319	202	15	terminal	terminal	NOUN
dti-1319	202	16	of	of	ADP
dti-1319	202	17	rna	rna	PROPN
dti-1319	202	18	polymerase	polymerase	NOUN
dti-1319	202	19	ii	ii	PROPN
dti-1319	202	20	and	and	CCONJ
dti-1319	202	21	subsequently	subsequently	ADV
dti-1319	202	22	activates	activate	VERB
dti-1319	202	23	the	the	DET
dti-1319	202	24	transcription	transcription	NOUN
dti-1319	202	25	machinery	machinery	NOUN
dti-1319	202	26	triggering	trigger	VERB
dti-1319	202	27	the	the	DET
dti-1319	202	28	effi	effi	PROPN
dti-1319	202	29	cient	cient	NOUN
dti-1319	202	30	synthesis	synthesis	NOUN
dti-1319	202	31	of	of	ADP
dti-1319	202	32	the	the	DET
dti-1319	202	33	entire	entire	ADJ
dti-1319	202	34	viral	viral	ADJ
dti-1319	202	35	rna	rna	NOUN
dti-1319	202	36	.	.	PUNCT
dti-1319	203	1	a	a	DET
dti-1319	203	2	na	na	ADV
dti-1319	203	3	-	-	PUNCT
dti-1319	203	4	based	base	VERB
dti-1319	203	5	drug	drug	NOUN
dti-1319	203	6	strongly	strongly	ADV
dti-1319	203	7	interacting	interact	VERB
dti-1319	203	8	with	with	ADP
dti-1319	203	9	tar	tar	NOUN
dti-1319	203	10	competes	compete	NOUN
dti-1319	203	11	with	with	ADP
dti-1319	203	12	the	the	DET
dti-1319	203	13	formation	formation	NOUN
dti-1319	203	14	of	of	ADP
dti-1319	203	15	the	the	DET
dti-1319	203	16	191	191	NUM
dti-1319	203	17	delivery	delivery	NOUN
dti-1319	203	18	systems	system	NOUN
dti-1319	203	19	of	of	ADP
dti-1319	203	20	nucleic	nucleic	ADJ
dti-1319	203	21	acids	acid	NOUN
dti-1319	203	22	drugs	drug	NOUN
dti-1319	203	23	drug	drug	NOUN
dti-1319	203	24	target	target	NOUN
dti-1319	203	25	insights	insight	VERB
dti-1319	203	26	2007:2	2007:2	NUM
dti-1319	203	27	transcription	transcription	NOUN
dti-1319	203	28	complex	complex	ADJ
dti-1319	203	29	and	and	CCONJ
dti-1319	203	30	consequently	consequently	ADV
dti-1319	203	31	inhibits	inhibit	VERB
dti-1319	203	32	the	the	DET
dti-1319	203	33	trans	tran	NOUN
dti-1319	203	34	-	-	NOUN
dti-1319	203	35	activation	activation	NOUN
dti-1319	203	36	of	of	ADP
dti-1319	203	37	the	the	DET
dti-1319	203	38	transcription	transcription	NOUN
dti-1319	203	39	apparatus	apparatus	NOUN
dti-1319	203	40	.	.	PUNCT
dti-1319	204	1	thus	thus	ADV
dti-1319	204	2	,	,	PUNCT
dti-1319	204	3	hiv-1	hiv-1	X
dti-1319	204	4	replication	replication	NOUN
dti-1319	204	5	is	be	AUX
dti-1319	204	6	compromised	compromise	VERB
dti-1319	204	7	.	.	PUNCT
dti-1319	205	1	moreover	moreover	ADV
dti-1319	205	2	,	,	PUNCT
dti-1319	205	3	since	since	SCONJ
dti-1319	205	4	the	the	DET
dti-1319	205	5	tar	tar	NOUN
dti-1319	205	6	element	element	NOUN
dti-1319	205	7	is	be	AUX
dti-1319	205	8	located	locate	VERB
dti-1319	205	9	in	in	ADP
dti-1319	205	10	close	close	ADJ
dti-1319	205	11	proximity	proximity	NOUN
dti-1319	205	12	to	to	ADP
dti-1319	205	13	the	the	DET
dti-1319	205	14	5′	5′	NUM
dti-1319	205	15	end	end	NOUN
dti-1319	205	16	of	of	ADP
dti-1319	205	17	the	the	DET
dti-1319	205	18	mature	mature	ADJ
dti-1319	205	19	mrna	mrna	NOUN
dti-1319	205	20	,	,	PUNCT
dti-1319	205	21	a	a	DET
dti-1319	205	22	tar	tar	NOUN
dti-1319	205	23	binder	binder	NOUN
dti-1319	205	24	could	could	AUX
dti-1319	205	25	interfere	interfere	VERB
dti-1319	205	26	with	with	ADP
dti-1319	205	27	the	the	DET
dti-1319	205	28	ribosomal	ribosomal	NOUN
dti-1319	205	29	machinery	machinery	NOUN
dti-1319	205	30	as	as	ADV
dti-1319	205	31	well	well	ADV
dti-1319	205	32	.	.	PUNCT
dti-1319	206	1	nas	nas	PROPN
dti-1319	206	2	,	,	PUNCT
dti-1319	206	3	including	include	VERB
dti-1319	206	4	antisense	antisense	NOUN
dti-1319	206	5	oligonuvleotides	oligonuvleotide	NOUN
dti-1319	206	6	,	,	PUNCT
dti-1319	206	7	sirna	sirna	PROPN
dti-1319	206	8	and	and	CCONJ
dti-1319	206	9	aptamers	aptamer	NOUN
dti-1319	206	10	were	be	AUX
dti-1319	206	11	employed	employ	VERB
dti-1319	206	12	in	in	ADP
dti-1319	206	13	many	many	ADJ
dti-1319	206	14	studies	study	NOUN
dti-1319	206	15	for	for	ADP
dti-1319	206	16	targeting	target	VERB
dti-1319	206	17	the	the	DET
dti-1319	206	18	tar	tar	NOUN
dti-1319	206	19	element	element	NOUN
dti-1319	206	20	(	(	PUNCT
dti-1319	206	21	turner	turner	PROPN
dti-1319	206	22	et	et	PROPN
dti-1319	206	23	al	al	PROPN
dti-1319	206	24	.	.	PROPN
dti-1319	206	25	2005	2005	NUM
dti-1319	206	26	;	;	PUNCT
dti-1319	206	27	yoshinari	yoshinari	PROPN
dti-1319	206	28	et	et	PROPN
dti-1319	206	29	al	al	PROPN
dti-1319	206	30	.	.	PROPN
dti-1319	206	31	2004	2004	NUM
dti-1319	206	32	;	;	PUNCT
dti-1319	206	33	ducongé	ducongé	ADJ
dti-1319	206	34	and	and	CCONJ
dti-1319	206	35	toulmé	toulmé	ADJ
dti-1319	206	36	,	,	PUNCT
dti-1319	206	37	1999	1999	NUM
dti-1319	206	38	)	)	PUNCT
dti-1319	206	39	.	.	PUNCT
dti-1319	207	1	the	the	DET
dti-1319	207	2	anti	anti	ADJ
dti-1319	207	3	-	-	ADJ
dti-1319	207	4	tar	tar	ADJ
dti-1319	207	5	rna	rna	NOUN
dti-1319	207	6	aptamer	aptamer	NOUN
dti-1319	207	7	(	(	PUNCT
dti-1319	207	8	ducongé	ducongé	ADJ
dti-1319	207	9	and	and	CCONJ
dti-1319	207	10	toulmé	toulmé	ADJ
dti-1319	207	11	,	,	PUNCT
dti-1319	207	12	1999	1999	NUM
dti-1319	207	13	)	)	PUNCT
dti-1319	207	14	was	be	AUX
dti-1319	207	15	optimized	optimize	VERB
dti-1319	207	16	by	by	ADP
dti-1319	207	17	chemical	chemical	PROPN
dti-1319	207	18	modifi	modifi	PROPN
dti-1319	207	19	cations	cation	NOUN
dti-1319	207	20	towards	towards	ADP
dti-1319	207	21	improved	improve	VERB
dti-1319	207	22	stability	stability	NOUN
dti-1319	207	23	regarding	regard	VERB
dti-1319	207	24	nuclease	nuclease	NOUN
dti-1319	207	25	resistance	resistance	NOUN
dti-1319	207	26	and	and	CCONJ
dti-1319	207	27	decreased	decrease	VERB
dti-1319	207	28	trans	tran	NOUN
dti-1319	207	29	-	-	NOUN
dti-1319	207	30	activation	activation	NOUN
dti-1319	207	31	of	of	ADP
dti-1319	207	32	transcription	transcription	NOUN
dti-1319	207	33	in	in	ADP
dti-1319	207	34	cell	cell	NOUN
dti-1319	207	35	nuclei	nucleus	NOUN
dti-1319	207	36	extract	extract	VERB
dti-1319	207	37	assays	assay	NOUN
dti-1319	207	38	(	(	PUNCT
dti-1319	207	39	darfeuille	darfeuille	NOUN
dti-1319	207	40	et	et	PROPN
dti-1319	207	41	al	al	PROPN
dti-1319	207	42	.	.	PROPN
dti-1319	207	43	2002a	2002a	NUM
dti-1319	207	44	;	;	PUNCT
dti-1319	207	45	darfeuille	darfeuille	NOUN
dti-1319	207	46	et	et	PROPN
dti-1319	207	47	al	al	PROPN
dti-1319	207	48	.	.	PROPN
dti-1319	207	49	2002b	2002b	NUM
dti-1319	207	50	;	;	PUNCT
dti-1319	207	51	darfeuille	darfeuille	NOUN
dti-1319	207	52	et	et	PROPN
dti-1319	207	53	al	al	PROPN
dti-1319	207	54	.	.	PROPN
dti-1319	207	55	2004	2004	NUM
dti-1319	207	56	;	;	PUNCT
dti-1319	207	57	kolb	kolb	PROPN
dti-1319	207	58	et	et	PROPN
dti-1319	207	59	al	al	PROPN
dti-1319	207	60	.	.	PROPN
dti-1319	207	61	2005	2005	NUM
dti-1319	207	62	;	;	PUNCT
dti-1319	207	63	toulmé	toulmé	PROPN
dti-1319	207	64	et	et	PROPN
dti-1319	207	65	al	al	PROPN
dti-1319	207	66	.	.	PROPN
dti-1319	207	67	2001	2001	NUM
dti-1319	207	68	)	)	PUNCT
dti-1319	207	69	.	.	PUNCT
dti-1319	208	1	other	other	ADJ
dti-1319	208	2	aptamers	aptamer	NOUN
dti-1319	208	3	were	be	AUX
dti-1319	208	4	also	also	ADV
dti-1319	208	5	developed	develop	VERB
dti-1319	208	6	interfering	interfere	VERB
dti-1319	208	7	with	with	ADP
dti-1319	208	8	hiv-1	hiv-1	ADJ
dti-1319	208	9	gene	gene	NOUN
dti-1319	208	10	expression	expression	NOUN
dti-1319	208	11	,	,	PUNCT
dti-1319	208	12	such	such	ADJ
dti-1319	208	13	as	as	ADP
dti-1319	208	14	the	the	DET
dti-1319	208	15	anti	anti	ADJ
dti-1319	208	16	-	-	ADJ
dti-1319	208	17	hiv	hiv	ADJ
dti-1319	208	18	rev	rev	ADJ
dti-1319	208	19	-	-	ADJ
dti-1319	208	20	binding	binding	ADJ
dti-1319	208	21	aptamer	aptamer	NOUN
dti-1319	208	22	(	(	PUNCT
dti-1319	208	23	rbeapt	rbeapt	PROPN
dti-1319	208	24	)	)	PUNCT
dti-1319	208	25	(	(	PUNCT
dti-1319	208	26	konopka	konopka	VERB
dti-1319	208	27	et	et	PROPN
dti-1319	208	28	al	al	PROPN
dti-1319	208	29	.	.	PROPN
dti-1319	208	30	1998	1998	NUM
dti-1319	208	31	)	)	PUNCT
dti-1319	208	32	.	.	PUNCT
dti-1319	209	1	konopka	konopka	PROPN
dti-1319	209	2	and	and	CCONJ
dti-1319	209	3	collaborators	collaborator	NOUN
dti-1319	209	4	used	use	VERB
dti-1319	209	5	cationic	cationic	ADJ
dti-1319	209	6	liposomes	liposome	NOUN
dti-1319	209	7	as	as	ADP
dti-1319	209	8	delivery	delivery	NOUN
dti-1319	209	9	vessels	vessel	NOUN
dti-1319	209	10	carrying	carry	VERB
dti-1319	209	11	the	the	DET
dti-1319	209	12	association	association	NOUN
dti-1319	209	13	of	of	ADP
dti-1319	209	14	rbeapt	rbeapt	NOUN
dti-1319	209	15	and	and	CCONJ
dti-1319	209	16	a	a	DET
dti-1319	209	17	ribozyme	ribozyme	NOUN
dti-1319	209	18	that	that	PRON
dti-1319	209	19	acts	act	VERB
dti-1319	209	20	against	against	ADP
dti-1319	209	21	the	the	DET
dti-1319	209	22	hiv-1	hiv-1	X
dti-1319	209	23	env	env	NOUN
dti-1319	209	24	gene	gene	NOUN
dti-1319	209	25	inhibiting	inhibit	VERB
dti-1319	209	26	viral	viral	ADJ
dti-1319	209	27	production	production	NOUN
dti-1319	209	28	(	(	PUNCT
dti-1319	209	29	konopka	konopka	VERB
dti-1319	209	30	et	et	PROPN
dti-1319	209	31	al	al	PROPN
dti-1319	209	32	.	.	PROPN
dti-1319	209	33	1998	1998	NUM
dti-1319	209	34	)	)	PUNCT
dti-1319	209	35	.	.	PUNCT
dti-1319	210	1	these	these	DET
dti-1319	210	2	data	datum	NOUN
dti-1319	210	3	provide	provide	VERB
dti-1319	210	4	strong	strong	ADJ
dti-1319	210	5	evidence	evidence	NOUN
dti-1319	210	6	for	for	ADP
dti-1319	210	7	the	the	DET
dti-1319	210	8	therapeutical	therapeutical	ADJ
dti-1319	210	9	potential	potential	NOUN
dti-1319	210	10	of	of	ADP
dti-1319	210	11	na	na	INTJ
dti-1319	210	12	ligands	ligand	NOUN
dti-1319	210	13	as	as	ADP
dti-1319	210	14	anti	anti	ADJ
dti-1319	210	15	-	-	ADJ
dti-1319	210	16	hiv	hiv	ADJ
dti-1319	210	17	agents	agent	NOUN
dti-1319	210	18	when	when	SCONJ
dti-1319	210	19	their	their	PRON
dti-1319	210	20	intracellular	intracellular	ADJ
dti-1319	210	21	delivery	delivery	NOUN
dti-1319	210	22	is	be	AUX
dti-1319	210	23	effi	effi	PROPN
dti-1319	210	24	cient	cient	NOUN
dti-1319	210	25	.	.	PUNCT
dti-1319	211	1	delivery	delivery	NOUN
dti-1319	211	2	systems	system	NOUN
dti-1319	211	3	for	for	ADP
dti-1319	211	4	sirna	sirna	PROPN
dti-1319	211	5	conjugation	conjugation	NOUN
dti-1319	211	6	of	of	ADP
dti-1319	211	7	na	na	NOUN
dti-1319	211	8	terminals	terminal	NOUN
dti-1319	211	9	with	with	ADP
dti-1319	211	10	lipophilic	lipophilic	ADJ
dti-1319	211	11	molecules	molecule	NOUN
dti-1319	211	12	has	have	AUX
dti-1319	211	13	been	be	AUX
dti-1319	211	14	reported	report	VERB
dti-1319	211	15	to	to	PART
dti-1319	211	16	improve	improve	VERB
dti-1319	211	17	or	or	CCONJ
dti-1319	211	18	direct	direct	ADJ
dti-1319	211	19	cellular	cellular	ADJ
dti-1319	211	20	uptake	uptake	NOUN
dti-1319	211	21	.	.	PUNCT
dti-1319	212	1	for	for	ADP
dti-1319	212	2	example	example	NOUN
dti-1319	212	3	,	,	PUNCT
dti-1319	212	4	sirnas	sirna	NOUN
dti-1319	212	5	conjugated	conjugate	VERB
dti-1319	212	6	with	with	ADP
dti-1319	212	7	cholesterol	cholesterol	NOUN
dti-1319	212	8	improved	improve	VERB
dti-1319	212	9	in	in	ADP
dti-1319	212	10	vitro	vitro	X
dti-1319	212	11	and	and	CCONJ
dti-1319	212	12	in	in	ADP
dti-1319	212	13	vivo	vivo	ADJ
dti-1319	212	14	permeation	permeation	NOUN
dti-1319	212	15	of	of	ADP
dti-1319	212	16	liver	liver	NOUN
dti-1319	212	17	cells	cell	NOUN
dti-1319	212	18	(	(	PUNCT
dti-1319	212	19	lorenz	lorenz	PROPN
dti-1319	212	20	et	et	PROPN
dti-1319	212	21	al	al	PROPN
dti-1319	212	22	.	.	PROPN
dti-1319	212	23	2004	2004	NUM
dti-1319	212	24	)	)	PUNCT
dti-1319	212	25	.	.	PUNCT
dti-1319	213	1	a	a	DET
dti-1319	213	2	number	number	NOUN
dti-1319	213	3	of	of	ADP
dti-1319	213	4	approaches	approach	NOUN
dti-1319	213	5	—	—	PUNCT
dti-1319	213	6	including	include	VERB
dti-1319	213	7	lipid	lipid	NOUN
dti-1319	213	8	-	-	PUNCT
dti-1319	213	9	based	base	VERB
dti-1319	213	10	formulation	formulation	NOUN
dti-1319	213	11	,	,	PUNCT
dti-1319	213	12	transmessenger	transmessenger	NOUN
dti-1319	213	13	(	(	PUNCT
dti-1319	213	14	niu	niu	PROPN
dti-1319	213	15	et	et	PROPN
dti-1319	213	16	al	al	PROPN
dti-1319	213	17	.	.	PROPN
dti-1319	213	18	2006	2006	NUM
dti-1319	213	19	)	)	PUNCT
dti-1319	213	20	and	and	CCONJ
dti-1319	213	21	complexation	complexation	NOUN
dti-1319	213	22	with	with	ADP
dti-1319	213	23	polyethylenimine	polyethylenimine	NOUN
dti-1319	213	24	(	(	PUNCT
dti-1319	213	25	grzelinski	grzelinski	INTJ
dti-1319	213	26	et	et	PROPN
dti-1319	213	27	al	al	PROPN
dti-1319	213	28	.	.	PROPN
dti-1319	213	29	2006	2006	NUM
dti-1319	213	30	)	)	PUNCT
dti-1319	213	31	,	,	PUNCT
dti-1319	213	32	cholesterol	cholesterol	NOUN
dti-1319	213	33	-	-	PUNCT
dti-1319	213	34	oligoarginine	oligoarginine	NOUN
dti-1319	213	35	(	(	PUNCT
dti-1319	213	36	kim	kim	PROPN
dti-1319	213	37	et	et	PROPN
dti-1319	213	38	al	al	PROPN
dti-1319	213	39	.	.	PROPN
dti-1319	213	40	2006	2006	NUM
dti-1319	213	41	)	)	PUNCT
dti-1319	213	42	,	,	PUNCT
dti-1319	213	43	a	a	DET
dti-1319	213	44	protamine	protamine	ADJ
dti-1319	213	45	-	-	PUNCT
dti-1319	213	46	fab	fab	NOUN
dti-1319	213	47	fusion	fusion	NOUN
dti-1319	213	48	protein	protein	NOUN
dti-1319	213	49	(	(	PUNCT
dti-1319	213	50	song	song	NOUN
dti-1319	213	51	et	et	PROPN
dti-1319	213	52	al	al	PROPN
dti-1319	213	53	.	.	PROPN
dti-1319	213	54	2005	2005	NUM
dti-1319	213	55	)	)	PUNCT
dti-1319	213	56	and	and	CCONJ
dti-1319	213	57	atelocollagen	atelocollagen	PROPN
dti-1319	213	58	(	(	PUNCT
dti-1319	213	59	takei	takei	PROPN
dti-1319	213	60	et	et	PROPN
dti-1319	213	61	al	al	PROPN
dti-1319	213	62	.	.	PROPN
dti-1319	213	63	2004	2004	NUM
dti-1319	213	64	;	;	PUNCT
dti-1319	213	65	minakuchi	minakuchi	PROPN
dti-1319	213	66	et	et	PROPN
dti-1319	213	67	al	al	PROPN
dti-1319	213	68	.	.	PROPN
dti-1319	214	1	2004)—have	2004)—have	PRON
dti-1319	214	2	been	be	AUX
dti-1319	214	3	shown	show	VERB
dti-1319	214	4	to	to	PART
dti-1319	214	5	facilitate	facilitate	VERB
dti-1319	214	6	delivery	delivery	NOUN
dti-1319	214	7	into	into	ADP
dti-1319	214	8	tumor	tumor	NOUN
dti-1319	214	9	cells	cell	NOUN
dti-1319	214	10	.	.	PUNCT
dti-1319	215	1	aptamer	aptamer	PROPN
dti-1319	215	2	-	-	PUNCT
dti-1319	215	3	sirna	sirna	PROPN
dti-1319	215	4	chimeric	chimeric	ADJ
dti-1319	215	5	rnas	rna	NOUN
dti-1319	215	6	have	have	AUX
dti-1319	215	7	also	also	ADV
dti-1319	215	8	been	be	AUX
dti-1319	215	9	successfully	successfully	ADV
dti-1319	215	10	used	use	VERB
dti-1319	215	11	to	to	PART
dti-1319	215	12	facilitate	facilitate	VERB
dti-1319	215	13	sirna	sirna	PROPN
dti-1319	215	14	delivery	delivery	NOUN
dti-1319	215	15	in	in	ADP
dti-1319	215	16	vivo	vivo	NOUN
dti-1319	215	17	(	(	PUNCT
dti-1319	215	18	mcnamara	mcnamara	PROPN
dti-1319	215	19	et	et	PROPN
dti-1319	215	20	al	al	PROPN
dti-1319	215	21	.	.	PROPN
dti-1319	215	22	2006	2006	NUM
dti-1319	215	23	;	;	PUNCT
dti-1319	215	24	chu	chu	PROPN
dti-1319	215	25	et	et	PROPN
dti-1319	215	26	al	al	PROPN
dti-1319	215	27	.	.	PROPN
dti-1319	215	28	2006	2006	NUM
dti-1319	215	29	)	)	PUNCT
dti-1319	216	1	(	(	PUNCT
dti-1319	216	2	fig.1	fig.1	PROPN
dti-1319	216	3	c	c	NOUN
dti-1319	216	4	)	)	PUNCT
dti-1319	216	5	.	.	PUNCT
dti-1319	217	1	in	in	ADP
dti-1319	217	2	2004	2004	NUM
dti-1319	217	3	,	,	PUNCT
dti-1319	217	4	soutschek	soutschek	NOUN
dti-1319	217	5	and	and	CCONJ
dti-1319	217	6	coworkers	coworker	NOUN
dti-1319	217	7	demonstrated	demonstrate	VERB
dti-1319	217	8	effective	effective	ADJ
dti-1319	217	9	silencing	silencing	NOUN
dti-1319	217	10	of	of	ADP
dti-1319	217	11	gene	gene	NOUN
dti-1319	217	12	expression	expression	NOUN
dti-1319	217	13	of	of	ADP
dti-1319	217	14	apolipoprotein	apolipoprotein	ADJ
dti-1319	217	15	apob	apob	PROPN
dti-1319	217	16	by	by	ADP
dti-1319	217	17	intravenous	intravenous	ADJ
dti-1319	217	18	administration	administration	NOUN
dti-1319	217	19	of	of	ADP
dti-1319	217	20	chemically	chemically	ADV
dti-1319	217	21	modifi	modifi	PROPN
dti-1319	217	22	ed	ed	PROPN
dti-1319	217	23	sirna	sirna	PROPN
dti-1319	217	24	which	which	PRON
dti-1319	217	25	resulted	result	VERB
dti-1319	217	26	in	in	ADP
dti-1319	217	27	silencing	silence	VERB
dti-1319	217	28	of	of	ADP
dti-1319	217	29	the	the	DET
dti-1319	217	30	apob	apob	PROPN
dti-1319	217	31	mrna	mrna	PROPN
dti-1319	217	32	in	in	ADP
dti-1319	217	33	liver	liver	NOUN
dti-1319	217	34	and	and	CCONJ
dti-1319	217	35	jejunum	jejunum	ADJ
dti-1319	217	36	,	,	PUNCT
dti-1319	217	37	decreased	decrease	VERB
dti-1319	217	38	plasma	plasma	NOUN
dti-1319	217	39	levels	level	NOUN
dti-1319	217	40	of	of	ADP
dti-1319	217	41	apob	apob	ADJ
dti-1319	217	42	protein	protein	NOUN
dti-1319	217	43	,	,	PUNCT
dti-1319	217	44	and	and	CCONJ
dti-1319	217	45	reduced	reduce	VERB
dti-1319	217	46	total	total	ADJ
dti-1319	217	47	cholesterol	cholesterol	NOUN
dti-1319	217	48	concentration	concentration	NOUN
dti-1319	217	49	in	in	ADP
dti-1319	217	50	mice	mouse	NOUN
dti-1319	217	51	(	(	PUNCT
dti-1319	217	52	soutschek	soutschek	NOUN
dti-1319	217	53	et	et	PROPN
dti-1319	217	54	al	al	PROPN
dti-1319	217	55	.	.	PROPN
dti-1319	217	56	2004	2004	NUM
dti-1319	217	57	)	)	PUNCT
dti-1319	217	58	.	.	PUNCT
dti-1319	218	1	judge	judge	PROPN
dti-1319	218	2	et	et	PROPN
dti-1319	218	3	al	al	PROPN
dti-1319	218	4	(	(	PUNCT
dti-1319	218	5	2005	2005	NUM
dti-1319	218	6	)	)	PUNCT
dti-1319	218	7	made	make	VERB
dti-1319	218	8	use	use	NOUN
dti-1319	218	9	of	of	ADP
dti-1319	218	10	sirna	sirna	PROPN
dti-1319	218	11	duplexes	duplex	NOUN
dti-1319	218	12	formulated	formulate	VERB
dti-1319	218	13	in	in	ADP
dti-1319	218	14	stable	stable	ADJ
dti-1319	218	15	na	na	ADP
dti-1319	218	16	lipid	lipid	NOUN
dti-1319	218	17	particles	particle	NOUN
dti-1319	218	18	(	(	PUNCT
dti-1319	218	19	snalps	snalp	NOUN
dti-1319	218	20	)	)	PUNCT
dti-1319	218	21	to	to	PART
dti-1319	218	22	attain	attain	VERB
dti-1319	218	23	gene	gene	NOUN
dti-1319	218	24	silencing	silencing	NOUN
dti-1319	218	25	of	of	ADP
dti-1319	218	26	apob	apob	PROPN
dti-1319	218	27	in	in	ADP
dti-1319	218	28	mice	mouse	NOUN
dti-1319	218	29	(	(	PUNCT
dti-1319	218	30	zimmermann	zimmermann	PROPN
dti-1319	218	31	et	et	PROPN
dti-1319	218	32	al	al	PROPN
dti-1319	218	33	.	.	PROPN
dti-1319	218	34	2006	2006	NUM
dti-1319	218	35	)	)	PUNCT
dti-1319	218	36	.	.	PUNCT
dti-1319	219	1	moreover	moreover	ADV
dti-1319	219	2	,	,	PUNCT
dti-1319	219	3	the	the	DET
dti-1319	219	4	general	general	ADJ
dti-1319	219	5	applicability	applicability	NOUN
dti-1319	219	6	of	of	ADP
dti-1319	219	7	snalp	snalp	PROPN
dti-1319	219	8	formulations	formulation	NOUN
dti-1319	219	9	for	for	ADP
dti-1319	219	10	hepatic	hepatic	ADJ
dti-1319	219	11	delivery	delivery	NOUN
dti-1319	219	12	of	of	ADP
dti-1319	219	13	sirna	sirna	PROPN
dti-1319	219	14	has	have	AUX
dti-1319	219	15	been	be	AUX
dti-1319	219	16	demonstrated	demonstrate	VERB
dti-1319	219	17	in	in	ADP
dti-1319	219	18	animal	animal	NOUN
dti-1319	219	19	models	model	NOUN
dti-1319	219	20	of	of	ADP
dti-1319	219	21	hbv	hbv	NOUN
dti-1319	219	22	and	and	CCONJ
dti-1319	219	23	ebola	ebola	PROPN
dti-1319	219	24	virus	virus	NOUN
dti-1319	219	25	infection	infection	NOUN
dti-1319	219	26	(	(	PUNCT
dti-1319	219	27	morrissey	morrissey	PROPN
dti-1319	219	28	et	et	PROPN
dti-1319	219	29	al	al	PROPN
dti-1319	219	30	.	.	PROPN
dti-1319	219	31	2005	2005	NUM
dti-1319	219	32	;	;	PUNCT
dti-1319	219	33	geisbert	geisbert	PROPN
dti-1319	219	34	et	et	PROPN
dti-1319	219	35	al	al	PROPN
dti-1319	219	36	.	.	PROPN
dti-1319	219	37	2006	2006	NUM
dti-1319	219	38	)	)	PUNCT
dti-1319	219	39	.	.	PUNCT
dti-1319	220	1	in	in	ADP
dti-1319	220	2	oncology	oncology	NOUN
dti-1319	220	3	,	,	PUNCT
dti-1319	220	4	direct	direct	ADJ
dti-1319	220	5	delivery	delivery	NOUN
dti-1319	220	6	of	of	ADP
dti-1319	220	7	sirnas	sirna	NOUN
dti-1319	220	8	and	and	CCONJ
dti-1319	220	9	viral	viral	ADJ
dti-1319	220	10	delivery	delivery	NOUN
dti-1319	220	11	of	of	ADP
dti-1319	220	12	small	small	ADJ
dti-1319	220	13	hairpin	hairpin	NOUN
dti-1319	220	14	(	(	PUNCT
dti-1319	220	15	sh)-rnas	sh)-rna	NOUN
dti-1319	220	16	to	to	ADP
dti-1319	220	17	tumors	tumor	NOUN
dti-1319	220	18	have	have	AUX
dti-1319	220	19	been	be	AUX
dti-1319	220	20	shown	show	VERB
dti-1319	220	21	to	to	PART
dti-1319	220	22	successfully	successfully	ADV
dti-1319	220	23	inhibit	inhibit	VERB
dti-1319	220	24	xenograft	xenograft	NOUN
dti-1319	220	25	growth	growth	NOUN
dti-1319	220	26	in	in	ADP
dti-1319	220	27	mouse	mouse	NOUN
dti-1319	220	28	models	model	NOUN
dti-1319	220	29	.	.	PUNCT
dti-1319	221	1	combination	combination	NOUN
dti-1319	221	2	of	of	ADP
dti-1319	221	3	sirna	sirna	PROPN
dti-1319	221	4	and	and	CCONJ
dti-1319	221	5	aptamers	aptamer	NOUN
dti-1319	221	6	in	in	ADP
dti-1319	221	7	therapeutics	therapeutic	NOUN
dti-1319	221	8	technologies	technology	NOUN
dti-1319	221	9	that	that	PRON
dti-1319	221	10	mediate	mediate	VERB
dti-1319	221	11	targeted	targeted	ADJ
dti-1319	221	12	delivery	delivery	NOUN
dti-1319	221	13	of	of	ADP
dti-1319	221	14	sirnas	sirna	NOUN
dti-1319	221	15	are	be	AUX
dti-1319	221	16	needed	need	VERB
dti-1319	221	17	to	to	PART
dti-1319	221	18	improve	improve	VERB
dti-1319	221	19	their	their	PRON
dti-1319	221	20	therapeutic	therapeutic	ADJ
dti-1319	221	21	effi	effi	PROPN
dti-1319	221	22	cacy	cacy	NOUN
dti-1319	221	23	and	and	CCONJ
dti-1319	221	24	safety	safety	NOUN
dti-1319	221	25	for	for	ADP
dti-1319	221	26	use	use	NOUN
dti-1319	221	27	in	in	ADP
dti-1319	221	28	humans	human	NOUN
dti-1319	221	29	.	.	PUNCT
dti-1319	222	1	lupold	lupold	INTJ
dti-1319	222	2	et	et	PROPN
dti-1319	222	3	al	al	PROPN
dti-1319	222	4	.	.	PROPN
dti-1319	223	1	(	(	PUNCT
dti-1319	223	2	2002	2002	NUM
dti-1319	223	3	)	)	PUNCT
dti-1319	223	4	identifi	identifi	PROPN
dti-1319	223	5	ed	ed	PROPN
dti-1319	223	6	two	two	NUM
dti-1319	223	7	aptamers	aptamer	NOUN
dti-1319	223	8	that	that	PRON
dti-1319	223	9	bind	bind	VERB
dti-1319	223	10	with	with	ADP
dti-1319	223	11	low	low	ADJ
dti-1319	223	12	nanomolar	nanomolar	ADJ
dti-1319	223	13	affinity	affinity	NOUN
dti-1319	223	14	to	to	ADP
dti-1319	223	15	the	the	DET
dti-1319	223	16	extracellular	extracellular	ADJ
dti-1319	223	17	portion	portion	NOUN
dti-1319	223	18	of	of	ADP
dti-1319	223	19	psma	psma	NOUN
dti-1319	223	20	.	.	PUNCT
dti-1319	224	1	the	the	DET
dti-1319	224	2	two	two	NUM
dti-1319	224	3	aptamers	aptamer	NOUN
dti-1319	224	4	,	,	PUNCT
dti-1319	224	5	denominated	denominate	VERB
dti-1319	224	6	as	as	ADP
dti-1319	224	7	xpsm	xpsm	NOUN
dti-1319	224	8	-	-	PUNCT
dti-1319	224	9	a9	a9	PROPN
dti-1319	224	10	and	and	CCONJ
dti-1319	224	11	xpsm	xpsm	NOUN
dti-1319	224	12	-	-	PUNCT
dti-1319	224	13	a10	a10	PROPN
dti-1319	224	14	,	,	PUNCT
dti-1319	224	15	did	do	AUX
dti-1319	224	16	not	not	PART
dti-1319	224	17	share	share	VERB
dti-1319	224	18	any	any	DET
dti-1319	224	19	consensus	consensus	NOUN
dti-1319	224	20	sequences	sequence	NOUN
dti-1319	224	21	and	and	CCONJ
dti-1319	224	22	bound	bind	VERB
dti-1319	224	23	to	to	ADP
dti-1319	224	24	different	different	ADJ
dti-1319	224	25	sites	site	NOUN
dti-1319	224	26	of	of	ADP
dti-1319	224	27	psma	psma	NOUN
dti-1319	224	28	.	.	PUNCT
dti-1319	225	1	distinct	distinct	ADJ
dti-1319	225	2	modes	mode	NOUN
dti-1319	225	3	of	of	ADP
dti-1319	225	4	inhibition	inhibition	NOUN
dti-1319	225	5	suggested	suggest	VERB
dti-1319	225	6	that	that	SCONJ
dti-1319	225	7	each	each	DET
dti-1319	225	8	aptamer	aptamer	NOUN
dti-1319	225	9	identifi	identifi	VERB
dti-1319	225	10	es	es	ADP
dti-1319	225	11	a	a	DET
dti-1319	225	12	unique	unique	ADJ
dti-1319	225	13	extracellular	extracellular	ADJ
dti-1319	225	14	epitope	epitope	NOUN
dti-1319	225	15	of	of	ADP
dti-1319	225	16	recombinant	recombinant	ADJ
dti-1319	225	17	psma	psma	NOUN
dti-1319	225	18	(	(	PUNCT
dti-1319	225	19	xpsm	xpsm	PROPN
dti-1319	225	20	)	)	PUNCT
dti-1319	225	21	.	.	PUNCT
dti-1319	226	1	these	these	DET
dti-1319	226	2	aptamers	aptamer	NOUN
dti-1319	226	3	were	be	AUX
dti-1319	226	4	the	the	DET
dti-1319	226	5	fi	fi	NOUN
dti-1319	226	6	rst	rst	NOUN
dti-1319	226	7	recognizing	recognize	VERB
dti-1319	226	8	specifi	specifi	PROPN
dti-1319	226	9	c	c	PROPN
dti-1319	226	10	prostate	prostate	NOUN
dti-1319	226	11	cancer	cancer	NOUN
dti-1319	226	12	markers	marker	NOUN
dti-1319	226	13	.	.	PUNCT
dti-1319	227	1	chu	chu	PROPN
dti-1319	227	2	et	et	PROPN
dti-1319	227	3	al	al	PROPN
dti-1319	227	4	.	.	PROPN
dti-1319	227	5	(	(	PUNCT
dti-1319	227	6	2006	2006	NUM
dti-1319	227	7	)	)	PUNCT
dti-1319	227	8	coupled	couple	VERB
dti-1319	227	9	sirnas	sirna	NOUN
dti-1319	227	10	interfering	interfere	VERB
dti-1319	227	11	with	with	ADP
dti-1319	227	12	laminin	laminin	NOUN
dti-1319	227	13	and	and	CCONJ
dti-1319	227	14	gapdh	gapdh	NOUN
dti-1319	227	15	gene	gene	NOUN
dti-1319	227	16	expression	expression	NOUN
dti-1319	227	17	by	by	ADP
dti-1319	227	18	a	a	DET
dti-1319	227	19	modular	modular	ADJ
dti-1319	227	20	streptavidin	streptavidin	NOUN
dti-1319	227	21	bridge	bridge	NOUN
dti-1319	227	22	to	to	ADP
dti-1319	227	23	the	the	DET
dti-1319	227	24	aptamer	aptamer	NOUN
dti-1319	227	25	a9	a9	NOUN
dti-1319	227	26	which	which	PRON
dti-1319	227	27	binds	bind	VERB
dti-1319	227	28	to	to	ADP
dti-1319	227	29	prostate	prostate	NOUN
dti-1319	227	30	-	-	PUNCT
dti-1319	227	31	cancer	cancer	NOUN
dti-1319	227	32	cells	cell	NOUN
dti-1319	227	33	.	.	PUNCT
dti-1319	228	1	comparison	comparison	NOUN
dti-1319	228	2	of	of	ADP
dti-1319	228	3	oligofectamine	oligofectamine	NOUN
dti-1319	228	4	(	(	PUNCT
dti-1319	228	5	invitrogen	invitrogen	PROPN
dti-1319	228	6	)	)	PUNCT
dti-1319	228	7	and	and	CCONJ
dti-1319	228	8	aptamer	aptamer	NOUN
dti-1319	228	9	-	-	PUNCT
dti-1319	228	10	mediated	mediate	VERB
dti-1319	228	11	sirna	sirna	PROPN
dti-1319	228	12	transfection	transfection	NOUN
dti-1319	228	13	resulted	result	VERB
dti-1319	228	14	in	in	ADP
dti-1319	228	15	similar	similar	ADJ
dti-1319	228	16	inhibition	inhibition	NOUN
dti-1319	228	17	of	of	ADP
dti-1319	228	18	target	target	NOUN
dti-1319	228	19	-	-	PUNCT
dti-1319	228	20	protein	protein	NOUN
dti-1319	228	21	expression	expression	NOUN
dti-1319	228	22	as	as	SCONJ
dti-1319	228	23	evaluated	evaluate	VERB
dti-1319	228	24	by	by	ADP
dti-1319	228	25	real	real	ADJ
dti-1319	228	26	-	-	PUNCT
dti-1319	228	27	time	time	NOUN
dti-1319	228	28	pcr	pcr	ADJ
dti-1319	228	29	experiments	experiment	NOUN
dti-1319	228	30	.	.	PUNCT
dti-1319	229	1	psma	psma	NOUN
dti-1319	229	2	endocytosis	endocytosis	NOUN
dti-1319	229	3	in	in	ADP
dti-1319	229	4	lncap	lncap	NOUN
dti-1319	229	5	cells	cell	NOUN
dti-1319	229	6	is	be	AUX
dti-1319	229	7	thought	think	VERB
dti-1319	229	8	to	to	PART
dti-1319	229	9	predominantly	predominantly	ADV
dti-1319	229	10	proceed	proceed	VERB
dti-1319	229	11	via	via	ADP
dti-1319	229	12	clathrin	clathrin	NOUN
dti-1319	229	13	-	-	PUNCT
dti-1319	229	14	coated	coat	VERB
dti-1319	229	15	pits	pit	NOUN
dti-1319	229	16	.	.	PUNCT
dti-1319	230	1	the	the	DET
dti-1319	230	2	rate	rate	NOUN
dti-1319	230	3	of	of	ADP
dti-1319	230	4	internalization	internalization	NOUN
dti-1319	230	5	has	have	AUX
dti-1319	230	6	been	be	AUX
dti-1319	230	7	previously	previously	ADV
dti-1319	230	8	measured	measure	VERB
dti-1319	230	9	using	use	VERB
dti-1319	230	10	antibodies	antibody	NOUN
dti-1319	230	11	directed	direct	VERB
dti-1319	230	12	against	against	ADP
dti-1319	230	13	psma	psma	NOUN
dti-1319	230	14	and	and	CCONJ
dti-1319	230	15	also	also	ADV
dti-1319	230	16	in	in	ADP
dti-1319	230	17	the	the	DET
dti-1319	230	18	presence	presence	NOUN
dti-1319	230	19	of	of	ADP
dti-1319	230	20	the	the	DET
dti-1319	230	21	anti	anti	ADJ
dti-1319	230	22	-	-	ADJ
dti-1319	230	23	psma	psma	ADJ
dti-1319	230	24	aptamer	aptamer	NOUN
dti-1319	230	25	a10	a10	PROPN
dti-1319	230	26	.	.	PUNCT
dti-1319	231	1	internalization	internalization	NOUN
dti-1319	231	2	was	be	AUX
dti-1319	231	3	shown	show	VERB
dti-1319	231	4	to	to	PART
dti-1319	231	5	take	take	VERB
dti-1319	231	6	place	place	NOUN
dti-1319	231	7	for	for	ADP
dti-1319	231	8	both	both	DET
dti-1319	231	9	types	type	NOUN
dti-1319	231	10	of	of	ADP
dti-1319	231	11	targeting	target	VERB
dti-1319	231	12	agents	agent	NOUN
dti-1319	231	13	within	within	ADP
dti-1319	231	14	hours	hour	NOUN
dti-1319	231	15	of	of	ADP
dti-1319	231	16	binding	bind	VERB
dti-1319	231	17	(	(	PUNCT
dti-1319	231	18	farokhzad	farokhzad	PROPN
dti-1319	231	19	et	et	PROPN
dti-1319	231	20	al	al	PROPN
dti-1319	231	21	.	.	PROPN
dti-1319	231	22	2004	2004	NUM
dti-1319	231	23	)	)	PUNCT
dti-1319	231	24	.	.	PUNCT
dti-1319	232	1	inhibition	inhibition	NOUN
dti-1319	232	2	of	of	ADP
dti-1319	232	3	target	target	NOUN
dti-1319	232	4	-	-	PUNCT
dti-1319	232	5	gene	gene	NOUN
dti-1319	232	6	expression	expression	NOUN
dti-1319	232	7	was	be	AUX
dti-1319	232	8	detected	detect	VERB
dti-1319	232	9	after	after	ADP
dti-1319	232	10	72	72	NUM
dti-1319	232	11	h	h	NOUN
dti-1319	232	12	of	of	ADP
dti-1319	232	13	sirnaaptamer	sirnaaptamer	PROPN
dti-1319	232	14	transfection	transfection	PROPN
dti-1319	232	15	.	.	PUNCT
dti-1319	233	1	mcnamara	mcnamara	PROPN
dti-1319	233	2	et	et	PROPN
dti-1319	233	3	al	al	PROPN
dti-1319	233	4	.	.	PROPN
dti-1319	233	5	(	(	PUNCT
dti-1319	233	6	2006	2006	NUM
dti-1319	233	7	)	)	PUNCT
dti-1319	233	8	generated	generate	VERB
dti-1319	233	9	a	a	DET
dti-1319	233	10	chimera	chimera	NOUN
dti-1319	233	11	of	of	ADP
dti-1319	233	12	a10	a10	NOUN
dti-1319	233	13	and	and	CCONJ
dti-1319	233	14	a	a	DET
dti-1319	233	15	sirna	sirna	PROPN
dti-1319	233	16	construct	construct	VERB
dti-1319	233	17	targeting	target	VERB
dti-1319	233	18	polo	polo	NOUN
dti-1319	233	19	-	-	PUNCT
dti-1319	233	20	like	like	ADP
dti-1319	233	21	192	192	NUM
dti-1319	233	22	ulrich	ulrich	PROPN
dti-1319	233	23	et	et	PROPN
dti-1319	233	24	al	al	PROPN
dti-1319	233	25	drug	drug	PROPN
dti-1319	233	26	target	target	NOUN
dti-1319	233	27	insights	insight	NOUN
dti-1319	233	28	2007:2	2007:2	NUM
dti-1319	233	29	kinase	kinase	NOUN
dti-1319	233	30	1	1	NUM
dti-1319	233	31	(	(	PUNCT
dti-1319	233	32	plk1	plk1	PROPN
dti-1319	233	33	)	)	PUNCT
dti-1319	233	34	and	and	CCONJ
dti-1319	233	35	bcl2	bcl2	PROPN
dti-1319	233	36	(	(	PUNCT
dti-1319	233	37	yano	yano	PROPN
dti-1319	233	38	et	et	PROPN
dti-1319	233	39	al	al	PROPN
dti-1319	233	40	.	.	PROPN
dti-1319	233	41	2004	2004	NUM
dti-1319	233	42	;	;	PUNCT
dti-1319	233	43	reagan	reagan	PROPN
dti-1319	233	44	-	-	PUNCT
dti-1319	233	45	shaw	shaw	PROPN
dti-1319	233	46	and	and	CCONJ
dti-1319	233	47	ahmad	ahmad	PROPN
dti-1319	233	48	,	,	PUNCT
dti-1319	233	49	2005	2005	NUM
dti-1319	233	50	)	)	PUNCT
dti-1319	233	51	as	as	SCONJ
dti-1319	233	52	two	two	NUM
dti-1319	233	53	survival	survival	NOUN
dti-1319	233	54	genes	gene	NOUN
dti-1319	233	55	overexpressed	overexpresse	VERB
dti-1319	233	56	in	in	ADP
dti-1319	233	57	most	most	ADJ
dti-1319	233	58	human	human	ADJ
dti-1319	233	59	tumors	tumor	NOUN
dti-1319	233	60	(	(	PUNCT
dti-1319	233	61	takai	takai	PROPN
dti-1319	233	62	et	et	PROPN
dti-1319	233	63	al	al	PROPN
dti-1319	233	64	.	.	PROPN
dti-1319	233	65	2004	2004	NUM
dti-1319	233	66	;	;	PUNCT
dti-1319	233	67	eckerdt	eckerdt	NOUN
dti-1319	233	68	et	et	PROPN
dti-1319	233	69	al	al	PROPN
dti-1319	233	70	.	.	PROPN
dti-1319	233	71	2005	2005	NUM
dti-1319	233	72	;	;	PUNCT
dti-1319	233	73	cory	cory	PROPN
dti-1319	233	74	and	and	CCONJ
dti-1319	233	75	adams	adam	NOUN
dti-1319	233	76	,	,	PUNCT
dti-1319	233	77	2005	2005	NUM
dti-1319	233	78	)	)	PUNCT
dti-1319	233	79	.	.	PUNCT
dti-1319	234	1	since	since	SCONJ
dti-1319	234	2	dicer	dicer	NOUN
dti-1319	234	3	also	also	ADV
dti-1319	234	4	acts	act	VERB
dti-1319	234	5	on	on	ADP
dti-1319	234	6	chimeric	chimeric	ADJ
dti-1319	234	7	rnas	rna	NOUN
dti-1319	234	8	,	,	PUNCT
dti-1319	234	9	aptamer	aptamer	NOUN
dti-1319	234	10	-	-	PUNCT
dti-1319	234	11	sirnas	sirna	NOUN
dti-1319	234	12	are	be	AUX
dti-1319	234	13	directed	direct	VERB
dti-1319	234	14	into	into	ADP
dti-1319	234	15	the	the	DET
dti-1319	234	16	rnai	rnai	PROPN
dti-1319	234	17	pathway	pathway	NOUN
dti-1319	234	18	and	and	CCONJ
dti-1319	234	19	silence	silence	VERB
dti-1319	234	20	their	their	PRON
dti-1319	234	21	cognate	cognate	NOUN
dti-1319	234	22	mrnas	mrna	NOUN
dti-1319	234	23	.	.	PUNCT
dti-1319	235	1	aptamer	aptamer	PROPN
dti-1319	235	2	-	-	PUNCT
dti-1319	235	3	sirna	sirna	PROPN
dti-1319	235	4	chimera	chimera	NOUN
dti-1319	235	5	–	–	PUNCT
dti-1319	235	6	mediated	mediate	VERB
dti-1319	235	7	gene	gene	NOUN
dti-1319	235	8	silencing	silence	VERB
dti-1319	235	9	is	be	AUX
dti-1319	235	10	dependent	dependent	ADJ
dti-1319	235	11	on	on	ADP
dti-1319	235	12	dicer	dicer	NOUN
dti-1319	235	13	activation	activation	NOUN
dti-1319	235	14	and	and	CCONJ
dti-1319	235	15	occurs	occur	VERB
dti-1319	235	16	via	via	ADP
dti-1319	235	17	the	the	DET
dti-1319	235	18	rnai	rnai	PROPN
dti-1319	235	19	pathway	pathway	NOUN
dti-1319	235	20	.	.	PUNCT
dti-1319	236	1	however	however	ADV
dti-1319	236	2	,	,	PUNCT
dti-1319	236	3	inhibition	inhibition	NOUN
dti-1319	236	4	of	of	ADP
dti-1319	236	5	dicer	dicer	NOUN
dti-1319	236	6	activation	activation	NOUN
dti-1319	236	7	had	have	VERB
dti-1319	236	8	no	no	DET
dti-1319	236	9	effect	effect	NOUN
dti-1319	236	10	on	on	ADP
dti-1319	236	11	transfected	transfecte	VERB
dti-1319	236	12	plk1	plk1	NOUN
dti-1319	236	13	sirnamediated	sirnamediate	VERB
dti-1319	236	14	silencing	silencing	NOUN
dti-1319	236	15	,	,	PUNCT
dti-1319	236	16	as	as	SCONJ
dti-1319	236	17	21to	21to	ADJ
dti-1319	236	18	23	23	NUM
dti-1319	236	19	-	-	PUNCT
dti-1319	236	20	nucleotide	nucleotide	NOUN
dti-1319	236	21	containing	contain	VERB
dti-1319	236	22	sirnas	sirna	NOUN
dti-1319	236	23	have	have	AUX
dti-1319	236	24	been	be	AUX
dti-1319	236	25	shown	show	VERB
dti-1319	236	26	to	to	PART
dti-1319	236	27	bypass	bypass	VERB
dti-1319	236	28	the	the	DET
dti-1319	236	29	dicer	dicer	NOUN
dti-1319	236	30	step	step	NOUN
dti-1319	236	31	(	(	PUNCT
dti-1319	236	32	murchison	murchison	PROPN
dti-1319	236	33	et	et	PROPN
dti-1319	236	34	al	al	PROPN
dti-1319	236	35	.	.	PROPN
dti-1319	236	36	2005	2005	NUM
dti-1319	236	37	)	)	PUNCT
dti-1319	236	38	.	.	PUNCT
dti-1319	237	1	the	the	DET
dti-1319	237	2	chimera	chimera	NOUN
dti-1319	237	3	a10	a10	PROPN
dti-1319	237	4	-	-	PUNCT
dti-1319	237	5	sirna	sirna	PROPN
dti-1319	237	6	specifi	specifi	PROPN
dti-1319	237	7	cally	cally	ADV
dti-1319	237	8	bound	bind	VERB
dti-1319	237	9	to	to	PART
dti-1319	237	10	psma	psma	VERB
dti-1319	237	11	on	on	ADP
dti-1319	237	12	the	the	DET
dti-1319	237	13	surface	surface	NOUN
dti-1319	237	14	of	of	ADP
dti-1319	237	15	lncap	lncap	NOUN
dti-1319	237	16	cells	cell	NOUN
dti-1319	237	17	but	but	CCONJ
dti-1319	237	18	did	do	AUX
dti-1319	237	19	not	not	PART
dti-1319	237	20	interact	interact	VERB
dti-1319	237	21	with	with	ADP
dti-1319	237	22	pc-3	pc-3	NOUN
dti-1319	237	23	prostate	prostate	NOUN
dti-1319	237	24	cancer	cancer	NOUN
dti-1319	237	25	cells	cell	NOUN
dti-1319	237	26	which	which	PRON
dti-1319	237	27	do	do	AUX
dti-1319	237	28	not	not	PART
dti-1319	237	29	express	express	VERB
dti-1319	237	30	psma	psma	NOUN
dti-1319	237	31	(	(	PUNCT
dti-1319	237	32	see	see	VERB
dti-1319	237	33	scheme	scheme	NOUN
dti-1319	237	34	in	in	ADP
dti-1319	237	35	fig.1c	fig.1c	PROPN
dti-1319	237	36	)	)	PUNCT
dti-1319	237	37	.	.	PUNCT
dti-1319	238	1	the	the	DET
dti-1319	238	2	combination	combination	NOUN
dti-1319	238	3	of	of	ADP
dti-1319	238	4	shrna	shrna	NOUN
dti-1319	238	5	and	and	CCONJ
dti-1319	238	6	aptamer	aptamer	NOUN
dti-1319	238	7	for	for	ADP
dti-1319	238	8	specifi	specifi	PROPN
dti-1319	238	9	c	c	PROPN
dti-1319	238	10	gene	gene	NOUN
dti-1319	238	11	expression	expression	NOUN
dti-1319	238	12	control	control	NOUN
dti-1319	238	13	in	in	ADP
dti-1319	238	14	target	target	NOUN
dti-1319	238	15	cells	cell	NOUN
dti-1319	238	16	was	be	AUX
dti-1319	238	17	accomplished	accomplish	VERB
dti-1319	238	18	by	by	ADP
dti-1319	238	19	an	an	DET
dti-1319	238	20	et	et	NOUN
dti-1319	238	21	al	al	PROPN
dti-1319	238	22	(	(	PUNCT
dti-1319	238	23	2006	2006	NUM
dti-1319	238	24	)	)	PUNCT
dti-1319	238	25	.	.	PUNCT
dti-1319	239	1	this	this	DET
dti-1319	239	2	research	research	NOUN
dti-1319	239	3	group	group	NOUN
dti-1319	239	4	constructed	construct	VERB
dti-1319	239	5	a	a	DET
dti-1319	239	6	vector	vector	NOUN
dti-1319	239	7	containing	contain	VERB
dti-1319	239	8	the	the	DET
dti-1319	239	9	theophyllinebinding	theophyllinebinde	VERB
dti-1319	239	10	aptamer	aptamer	NOUN
dti-1319	239	11	(	(	PUNCT
dti-1319	239	12	jenison	jenison	PROPN
dti-1319	239	13	et	et	PROPN
dti-1319	239	14	al	al	PROPN
dti-1319	239	15	.	.	PROPN
dti-1319	239	16	1994	1994	NUM
dti-1319	239	17	;	;	PUNCT
dti-1319	239	18	zimmermann	zimmermann	PROPN
dti-1319	239	19	et	et	PROPN
dti-1319	239	20	al	al	PROPN
dti-1319	239	21	.	.	PROPN
dti-1319	239	22	1997	1997	NUM
dti-1319	239	23	)	)	PUNCT
dti-1319	239	24	and	and	CCONJ
dti-1319	239	25	the	the	DET
dti-1319	239	26	loop	loop	NOUN
dti-1319	239	27	region	region	NOUN
dti-1319	239	28	of	of	ADP
dti-1319	239	29	the	the	DET
dti-1319	239	30	shrna	shrna	NOUN
dti-1319	239	31	targeting	target	VERB
dti-1319	239	32	the	the	DET
dti-1319	239	33	enhanced	enhanced	ADJ
dti-1319	239	34	green	green	ADJ
dti-1319	239	35	fl	fl	ADP
dti-1319	239	36	uorescent	uorescent	ADJ
dti-1319	239	37	protein	protein	NOUN
dti-1319	239	38	(	(	PUNCT
dti-1319	239	39	egfp	egfp	NOUN
dti-1319	239	40	)	)	PUNCT
dti-1319	239	41	under	under	ADP
dti-1319	239	42	u6	u6	ADJ
dti-1319	239	43	promoter	promoter	NOUN
dti-1319	239	44	expression	expression	NOUN
dti-1319	239	45	.	.	PUNCT
dti-1319	240	1	when	when	SCONJ
dti-1319	240	2	this	this	DET
dti-1319	240	3	construct	construct	NOUN
dti-1319	240	4	was	be	AUX
dti-1319	240	5	co	co	VERB
dti-1319	240	6	-	-	VERB
dti-1319	240	7	transfected	transfecte	VERB
dti-1319	240	8	with	with	ADP
dti-1319	240	9	a	a	DET
dti-1319	240	10	construct	construct	NOUN
dti-1319	240	11	coding	code	VERB
dti-1319	240	12	for	for	ADP
dti-1319	240	13	egfp	egfp	NOUN
dti-1319	240	14	expression	expression	NOUN
dti-1319	240	15	(	(	PUNCT
dti-1319	240	16	pegfp	pegfp	NOUN
dti-1319	240	17	-	-	PUNCT
dti-1319	240	18	n1	n1	NOUN
dti-1319	240	19	)	)	PUNCT
dti-1319	240	20	into	into	ADP
dti-1319	240	21	hek	hek	PROPN
dti-1319	240	22	cells	cell	NOUN
dti-1319	240	23	,	,	PUNCT
dti-1319	240	24	shrna	shrna	NOUN
dti-1319	240	25	-	-	PUNCT
dti-1319	240	26	induced	induce	VERB
dti-1319	240	27	egfp	egfp	NOUN
dti-1319	240	28	gene	gene	NOUN
dti-1319	240	29	expression	expression	NOUN
dti-1319	240	30	silencing	silence	VERB
dti-1319	240	31	was	be	AUX
dti-1319	240	32	dose	dose	VERB
dti-1319	240	33	-	-	PUNCT
dti-1319	240	34	dependently	dependently	ADV
dti-1319	240	35	inhibited	inhibit	VERB
dti-1319	240	36	by	by	ADP
dti-1319	240	37	increasing	increase	VERB
dti-1319	240	38	concentrations	concentration	NOUN
dti-1319	240	39	of	of	ADP
dti-1319	240	40	theophylline	theophylline	NOUN
dti-1319	240	41	,	,	PUNCT
dti-1319	240	42	as	as	SCONJ
dti-1319	240	43	aptamer	aptamer	NOUN
dti-1319	240	44	-	-	PUNCT
dti-1319	240	45	bound	bind	VERB
dti-1319	240	46	theophylline	theophylline	NOUN
dti-1319	240	47	interfered	interfere	VERB
dti-1319	240	48	with	with	ADP
dti-1319	240	49	the	the	DET
dti-1319	240	50	dicer	dicer	NOUN
dti-1319	240	51	-	-	PUNCT
dti-1319	240	52	cleavage	cleavage	NOUN
dti-1319	240	53	site	site	NOUN
dti-1319	240	54	.	.	PUNCT
dti-1319	241	1	this	this	DET
dti-1319	241	2	study	study	NOUN
dti-1319	241	3	proved	prove	VERB
dti-1319	241	4	the	the	DET
dti-1319	241	5	feasibility	feasibility	NOUN
dti-1319	241	6	of	of	ADP
dti-1319	241	7	modulation	modulation	NOUN
dti-1319	241	8	of	of	ADP
dti-1319	241	9	gene	gene	NOUN
dti-1319	241	10	expression	expression	NOUN
dti-1319	241	11	under	under	ADP
dti-1319	241	12	the	the	DET
dti-1319	241	13	control	control	NOUN
dti-1319	241	14	of	of	ADP
dti-1319	241	15	intracellular	intracellular	ADJ
dti-1319	241	16	proteins	protein	NOUN
dti-1319	241	17	or	or	CCONJ
dti-1319	241	18	cell	cell	NOUN
dti-1319	241	19	metabolites	metabolite	NOUN
dti-1319	241	20	(	(	PUNCT
dti-1319	241	21	an	an	DET
dti-1319	241	22	et	et	PROPN
dti-1319	241	23	al	al	PROPN
dti-1319	241	24	.	.	PROPN
dti-1319	241	25	2006	2006	NUM
dti-1319	241	26	)	)	PUNCT
dti-1319	241	27	.	.	PUNCT
dti-1319	242	1	recent	recent	ADJ
dti-1319	242	2	clinical	clinical	ADJ
dti-1319	242	3	developments	development	NOUN
dti-1319	242	4	one	one	NUM
dti-1319	242	5	of	of	ADP
dti-1319	242	6	the	the	DET
dti-1319	242	7	fastest	fast	ADJ
dti-1319	242	8	approvals	approval	NOUN
dti-1319	242	9	ever	ever	ADV
dti-1319	242	10	obtained	obtain	VERB
dti-1319	242	11	for	for	ADP
dti-1319	242	12	a	a	DET
dti-1319	242	13	drug	drug	NOUN
dti-1319	242	14	by	by	ADP
dti-1319	242	15	the	the	DET
dti-1319	242	16	fda	fda	PROPN
dti-1319	242	17	was	be	AUX
dti-1319	242	18	for	for	ADP
dti-1319	242	19	imatinib	imatinib	NOUN
dti-1319	242	20	(	(	PUNCT
dti-1319	242	21	imatinib	imatinib	NOUN
dti-1319	242	22	mesylate	mesylate	VERB
dti-1319	242	23	[	[	X
dti-1319	242	24	gleevec	gleevec	X
dti-1319	242	25	]	]	X
dti-1319	242	26	,	,	PUNCT
dti-1319	242	27	from	from	ADP
dti-1319	242	28	novartis	novartis	PROPN
dti-1319	242	29	)	)	PUNCT
dti-1319	242	30	for	for	ADP
dti-1319	242	31	the	the	DET
dti-1319	242	32	treatment	treatment	NOUN
dti-1319	242	33	of	of	ADP
dti-1319	242	34	chronic	chronic	ADJ
dti-1319	242	35	myelogenous	myelogenous	ADJ
dti-1319	242	36	leukemia	leukemia	NOUN
dti-1319	242	37	(	(	PUNCT
dti-1319	242	38	cml	cml	PROPN
dti-1319	242	39	)	)	PUNCT
dti-1319	242	40	.	.	PUNCT
dti-1319	243	1	although	although	SCONJ
dti-1319	243	2	the	the	DET
dti-1319	243	3	incidence	incidence	NOUN
dti-1319	243	4	of	of	ADP
dti-1319	243	5	cml	cml	PROPN
dti-1319	243	6	is	be	AUX
dti-1319	243	7	low	low	ADJ
dti-1319	243	8	,	,	PUNCT
dti-1319	243	9	the	the	DET
dti-1319	243	10	rate	rate	NOUN
dti-1319	243	11	of	of	ADP
dti-1319	243	12	cure	cure	NOUN
dti-1319	243	13	with	with	ADP
dti-1319	243	14	conventional	conventional	ADJ
dti-1319	243	15	treatment	treatment	NOUN
dti-1319	243	16	is	be	AUX
dti-1319	243	17	poor	poor	ADJ
dti-1319	243	18	.	.	PUNCT
dti-1319	244	1	gleevec	gleevec	PROPN
dti-1319	244	2	is	be	AUX
dti-1319	244	3	a	a	DET
dti-1319	244	4	tyrosine	tyrosine	NOUN
dti-1319	244	5	kinase	kinase	NOUN
dti-1319	244	6	inhibitor	inhibitor	NOUN
dti-1319	244	7	and	and	CCONJ
dti-1319	244	8	affects	affect	VERB
dti-1319	244	9	only	only	ADV
dti-1319	244	10	the	the	DET
dti-1319	244	11	leukemic	leukemic	ADJ
dti-1319	244	12	cells	cell	NOUN
dti-1319	244	13	that	that	PRON
dti-1319	244	14	are	be	AUX
dti-1319	244	15	caused	cause	VERB
dti-1319	244	16	by	by	ADP
dti-1319	244	17	fusion	fusion	NOUN
dti-1319	244	18	of	of	ADP
dti-1319	244	19	two	two	NUM
dti-1319	244	20	genes	gene	NOUN
dti-1319	244	21	,	,	PUNCT
dti-1319	244	22	bcr	bcr	PROPN
dti-1319	244	23	and	and	CCONJ
dti-1319	244	24	abl	abl	PROPN
dti-1319	244	25	,	,	PUNCT
dti-1319	244	26	a	a	DET
dti-1319	244	27	chromosomal	chromosomal	ADJ
dti-1319	244	28	shuffling	shuffling	NOUN
dti-1319	244	29	between	between	ADP
dti-1319	244	30	chromosomes	chromosome	NOUN
dti-1319	244	31	9	9	NUM
dti-1319	244	32	and	and	CCONJ
dti-1319	244	33	22	22	NUM
dti-1319	244	34	.	.	PUNCT
dti-1319	245	1	although	although	SCONJ
dti-1319	245	2	expensive	expensive	ADJ
dti-1319	245	3	,	,	PUNCT
dti-1319	245	4	gleevec	gleevec	PROPN
dti-1319	245	5	,	,	PUNCT
dti-1319	245	6	an	an	DET
dti-1319	245	7	oral	oral	ADJ
dti-1319	245	8	drug	drug	NOUN
dti-1319	245	9	,	,	PUNCT
dti-1319	245	10	led	lead	VERB
dti-1319	245	11	to	to	ADP
dti-1319	245	12	remission	remission	NOUN
dti-1319	245	13	in	in	ADP
dti-1319	245	14	90	90	NUM
dti-1319	245	15	%	%	NOUN
dti-1319	245	16	to	to	PART
dti-1319	245	17	95	95	NUM
dti-1319	245	18	%	%	NOUN
dti-1319	245	19	of	of	ADP
dti-1319	245	20	cml	cml	PROPN
dti-1319	245	21	-	-	PUNCT
dti-1319	245	22	relapsed	relapse	VERB
dti-1319	245	23	patients	patient	NOUN
dti-1319	245	24	.	.	PUNCT
dti-1319	246	1	however	however	ADV
dti-1319	246	2	,	,	PUNCT
dti-1319	246	3	it	it	PRON
dti-1319	246	4	has	have	AUX
dti-1319	246	5	not	not	PART
dti-1319	246	6	worked	work	VERB
dti-1319	246	7	well	well	ADV
dti-1319	246	8	in	in	ADP
dti-1319	246	9	blast	blast	NOUN
dti-1319	246	10	crisis	crisis	NOUN
dti-1319	246	11	.	.	PUNCT
dti-1319	247	1	current	current	ADJ
dti-1319	247	2	activities	activity	NOUN
dti-1319	247	3	of	of	ADP
dti-1319	247	4	the	the	DET
dti-1319	247	5	cytrx	cytrx	NOUN
dti-1319	247	6	corporation	corporation	NOUN
dti-1319	247	7	are	be	AUX
dti-1319	247	8	concentrated	concentrate	VERB
dti-1319	247	9	in	in	ADP
dti-1319	247	10	the	the	DET
dti-1319	247	11	development	development	NOUN
dti-1319	247	12	of	of	ADP
dti-1319	247	13	small	small	ADJ
dti-1319	247	14	molecule	molecule	NOUN
dti-1319	247	15	drugs	drug	NOUN
dti-1319	247	16	,	,	PUNCT
dti-1319	247	17	rnai	rnai	PROPN
dti-1319	247	18	drug	drug	PROPN
dti-1319	247	19	discovery	discovery	PROPN
dti-1319	247	20	and	and	CCONJ
dti-1319	247	21	dna	dna	NOUN
dti-1319	247	22	vaccines	vaccine	NOUN
dti-1319	247	23	and	and	CCONJ
dti-1319	247	24	a	a	DET
dti-1319	247	25	delivery	delivery	NOUN
dti-1319	247	26	technology	technology	NOUN
dti-1319	247	27	with	with	ADP
dti-1319	247	28	multiple	multiple	ADJ
dti-1319	247	29	applications	application	NOUN
dti-1319	247	30	in	in	ADP
dti-1319	247	31	the	the	DET
dti-1319	247	32	area	area	NOUN
dti-1319	247	33	of	of	ADP
dti-1319	247	34	dna	dna	PROPN
dti-1319	247	35	vaccine	vaccine	NOUN
dti-1319	247	36	and	and	CCONJ
dti-1319	247	37	gene	gene	NOUN
dti-1319	247	38	therapy	therapy	NOUN
dti-1319	247	39	.	.	PUNCT
dti-1319	248	1	its	its	PRON
dti-1319	248	2	proprietary	proprietary	ADJ
dti-1319	248	3	poloxamer	poloxamer	NOUN
dti-1319	248	4	compound	compound	PROPN
dti-1319	248	5	,	,	PUNCT
dti-1319	248	6	tranzfect	tranzfect	NOUN
dti-1319	248	7	,	,	PUNCT
dti-1319	248	8	has	have	AUX
dti-1319	248	9	revealed	reveal	VERB
dti-1319	248	10	good	good	ADJ
dti-1319	248	11	results	result	NOUN
dti-1319	248	12	regarding	regard	VERB
dti-1319	248	13	its	its	PRON
dti-1319	248	14	transfection	transfection	NOUN
dti-1319	248	15	ability	ability	NOUN
dti-1319	248	16	,	,	PUNCT
dti-1319	248	17	immunoadjuvant	immunoadjuvant	ADJ
dti-1319	248	18	activity	activity	NOUN
dti-1319	248	19	and	and	CCONJ
dti-1319	248	20	toxicity	toxicity	NOUN
dti-1319	248	21	profi	profi	PROPN
dti-1319	248	22	le	le	PROPN
dti-1319	248	23	as	as	ADP
dti-1319	248	24	prerequisites	prerequisite	NOUN
dti-1319	248	25	for	for	ADP
dti-1319	248	26	dna	dna	NOUN
dti-1319	248	27	-	-	PUNCT
dti-1319	248	28	based	base	VERB
dti-1319	248	29	vaccines	vaccine	NOUN
dti-1319	248	30	.	.	PUNCT
dti-1319	249	1	this	this	DET
dti-1319	249	2	company	company	NOUN
dti-1319	249	3	also	also	ADV
dti-1319	249	4	participates	participate	VERB
dti-1319	249	5	in	in	ADP
dti-1319	249	6	the	the	DET
dti-1319	249	7	development	development	NOUN
dti-1319	249	8	of	of	ADP
dti-1319	249	9	gene	gene	NOUN
dti-1319	249	10	-	-	PUNCT
dti-1319	249	11	silencing	silence	VERB
dti-1319	249	12	technologies	technology	NOUN
dti-1319	249	13	for	for	ADP
dti-1319	249	14	treatment	treatment	NOUN
dti-1319	249	15	of	of	ADP
dti-1319	249	16	amyotrophic	amyotrophic	ADJ
dti-1319	249	17	lateral	lateral	ADJ
dti-1319	249	18	sclerosis	sclerosis	NOUN
dti-1319	249	19	,	,	PUNCT
dti-1319	249	20	type	type	NOUN
dti-1319	249	21	ii	ii	NOUN
dti-1319	249	22	diabetes	diabetes	NOUN
dti-1319	249	23	,	,	PUNCT
dti-1319	249	24	cmv	cmv	PROPN
dti-1319	249	25	retinitis	retinitis	NOUN
dti-1319	249	26	,	,	PUNCT
dti-1319	249	27	obesity	obesity	NOUN
dti-1319	249	28	,	,	PUNCT
dti-1319	249	29	and	and	CCONJ
dti-1319	249	30	cancer	cancer	NOUN
dti-1319	249	31	.	.	PUNCT
dti-1319	250	1	targeting	target	VERB
dti-1319	250	2	of	of	ADP
dti-1319	250	3	the	the	DET
dti-1319	250	4	epidermal	epidermal	ADJ
dti-1319	250	5	growth	growth	NOUN
dti-1319	250	6	factor	factor	NOUN
dti-1319	250	7	(	(	PUNCT
dti-1319	250	8	egf	egf	NOUN
dti-1319	250	9	)	)	PUNCT
dti-1319	250	10	receptor	receptor	NOUN
dti-1319	250	11	by	by	ADP
dti-1319	250	12	pegylated	pegylated	ADJ
dti-1319	250	13	immunoliposomes	immunoliposome	NOUN
dti-1319	250	14	carrying	carry	VERB
dti-1319	250	15	a	a	DET
dti-1319	250	16	plasmid	plasmid	NOUN
dti-1319	250	17	coding	coding	NOUN
dti-1319	250	18	for	for	ADP
dti-1319	250	19	the	the	DET
dti-1319	250	20	shrna	shrna	NOUN
dti-1319	250	21	prolonged	prolong	VERB
dti-1319	250	22	the	the	DET
dti-1319	250	23	survival	survival	NOUN
dti-1319	250	24	of	of	ADP
dti-1319	250	25	mice	mouse	NOUN
dti-1319	250	26	with	with	ADP
dti-1319	250	27	intracranial	intracranial	ADJ
dti-1319	250	28	human	human	ADJ
dti-1319	250	29	brain	brain	NOUN
dti-1319	250	30	cancer	cancer	NOUN
dti-1319	250	31	(	(	PUNCT
dti-1319	250	32	zhang	zhang	PROPN
dti-1319	250	33	et	et	PROPN
dti-1319	250	34	al	al	PROPN
dti-1319	250	35	.	.	PROPN
dti-1319	250	36	2004	2004	NUM
dti-1319	250	37	)	)	PUNCT
dti-1319	250	38	.	.	PUNCT
dti-1319	251	1	the	the	DET
dti-1319	251	2	observation	observation	NOUN
dti-1319	251	3	that	that	PRON
dti-1319	251	4	encapsulated	encapsulate	VERB
dti-1319	251	5	oligonucleotides	oligonucleotide	NOUN
dti-1319	251	6	readily	readily	ADV
dti-1319	251	7	passed	pass	VERB
dti-1319	251	8	the	the	DET
dti-1319	251	9	blood	blood	NOUN
dti-1319	251	10	-	-	PUNCT
dti-1319	251	11	brain	brain	NOUN
dti-1319	251	12	barrier	barrier	NOUN
dti-1319	251	13	,	,	PUNCT
dti-1319	251	14	encourages	encourage	VERB
dti-1319	251	15	the	the	DET
dti-1319	251	16	development	development	NOUN
dti-1319	251	17	of	of	ADP
dti-1319	251	18	na	na	NOUN
dti-1319	251	19	-	-	PUNCT
dti-1319	251	20	based	base	VERB
dti-1319	251	21	therapies	therapy	NOUN
dti-1319	251	22	for	for	ADP
dti-1319	251	23	neurodegenerative	neurodegenerative	ADJ
dti-1319	251	24	diseases	disease	NOUN
dti-1319	251	25	(	(	PUNCT
dti-1319	251	26	reviewed	review	VERB
dti-1319	251	27	by	by	ADP
dti-1319	251	28	sa	sa	PROPN
dti-1319	251	29	,	,	PUNCT
dti-1319	251	30	2004	2004	NUM
dti-1319	251	31	)	)	PUNCT
dti-1319	251	32	.	.	PUNCT
dti-1319	252	1	conclusions	conclusion	NOUN
dti-1319	252	2	in	in	ADP
dti-1319	252	3	the	the	DET
dti-1319	252	4	nanotechnology	nanotechnology	PROPN
dti-1319	252	5	fi	fi	PROPN
dti-1319	252	6	eld	eld	PROPN
dti-1319	252	7	,	,	PUNCT
dti-1319	252	8	aptamers	aptamer	NOUN
dti-1319	252	9	have	have	VERB
dti-1319	252	10	the	the	DET
dti-1319	252	11	potential	potential	NOUN
dti-1319	252	12	to	to	PART
dti-1319	252	13	act	act	VERB
dti-1319	252	14	as	as	ADP
dti-1319	252	15	targeting	target	VERB
dti-1319	252	16	molecules	molecule	NOUN
dti-1319	252	17	by	by	ADP
dti-1319	252	18	directing	direct	VERB
dti-1319	252	19	the	the	DET
dti-1319	252	20	delivery	delivery	NOUN
dti-1319	252	21	of	of	ADP
dti-1319	252	22	nanoparticles	nanoparticle	NOUN
dti-1319	252	23	to	to	ADP
dti-1319	252	24	antigens	antigen	NOUN
dti-1319	252	25	present	present	ADJ
dti-1319	252	26	on	on	ADP
dti-1319	252	27	the	the	DET
dti-1319	252	28	surface	surface	NOUN
dti-1319	252	29	of	of	ADP
dti-1319	252	30	target	target	NOUN
dti-1319	252	31	cells	cell	NOUN
dti-1319	252	32	.	.	PUNCT
dti-1319	253	1	in	in	ADP
dti-1319	253	2	general	general	ADJ
dti-1319	253	3	terms	term	NOUN
dti-1319	253	4	,	,	PUNCT
dti-1319	253	5	therapeutic	therapeutic	ADJ
dti-1319	253	6	nanoparticles	nanoparticle	NOUN
dti-1319	253	7	are	be	AUX
dti-1319	253	8	components	component	NOUN
dti-1319	253	9	of	of	ADP
dti-1319	253	10	specialized	specialized	ADJ
dti-1319	253	11	delivery	delivery	NOUN
dti-1319	253	12	vehicles	vehicle	NOUN
dti-1319	253	13	of	of	ADP
dti-1319	253	14	an	an	DET
dti-1319	253	15	encapsulated	encapsulate	VERB
dti-1319	253	16	drug	drug	NOUN
dti-1319	253	17	.	.	PUNCT
dti-1319	254	1	drug	drug	NOUN
dti-1319	254	2	release	release	NOUN
dti-1319	254	3	should	should	AUX
dti-1319	254	4	occur	occur	VERB
dti-1319	254	5	in	in	ADP
dti-1319	254	6	a	a	DET
dti-1319	254	7	regulated	regulate	VERB
dti-1319	254	8	and	and	CCONJ
dti-1319	254	9	defi	defi	NOUN
dti-1319	254	10	ned	ned	PROPN
dti-1319	254	11	manner	manner	NOUN
dti-1319	254	12	.	.	PUNCT
dti-1319	255	1	depending	depend	VERB
dti-1319	255	2	on	on	ADP
dti-1319	255	3	the	the	DET
dti-1319	255	4	therapeutic	therapeutic	ADJ
dti-1319	255	5	demand	demand	NOUN
dti-1319	255	6	,	,	PUNCT
dti-1319	255	7	such	such	ADJ
dti-1319	255	8	devices	device	NOUN
dti-1319	255	9	are	be	AUX
dti-1319	255	10	designed	design	VERB
dti-1319	255	11	to	to	PART
dti-1319	255	12	ensure	ensure	VERB
dti-1319	255	13	continuous	continuous	ADJ
dti-1319	255	14	or	or	CCONJ
dti-1319	255	15	immediate	immediate	ADJ
dti-1319	255	16	drug	drug	NOUN
dti-1319	255	17	release	release	NOUN
dti-1319	255	18	.	.	PUNCT
dti-1319	256	1	the	the	DET
dti-1319	256	2	combination	combination	NOUN
dti-1319	256	3	of	of	ADP
dti-1319	256	4	targeted	target	VERB
dti-1319	256	5	delivery	delivery	NOUN
dti-1319	256	6	and	and	CCONJ
dti-1319	256	7	controlled	control	VERB
dti-1319	256	8	release	release	NOUN
dti-1319	256	9	of	of	ADP
dti-1319	256	10	drugs	drug	NOUN
dti-1319	256	11	at	at	ADP
dti-1319	256	12	affected	affect	VERB
dti-1319	256	13	tissue	tissue	NOUN
dti-1319	256	14	sites	site	NOUN
dti-1319	256	15	will	will	AUX
dti-1319	256	16	lead	lead	VERB
dti-1319	256	17	to	to	ADP
dti-1319	256	18	the	the	DET
dti-1319	256	19	development	development	NOUN
dti-1319	256	20	of	of	ADP
dti-1319	256	21	“	"	PUNCT
dti-1319	256	22	smart	smart	ADJ
dti-1319	256	23	therapeutics	therapeutic	NOUN
dti-1319	256	24	”	"	PUNCT
dti-1319	256	25	,	,	PUNCT
dti-1319	256	26	which	which	PRON
dti-1319	256	27	are	be	AUX
dti-1319	256	28	more	more	ADV
dti-1319	256	29	effective	effective	ADJ
dti-1319	256	30	and	and	CCONJ
dti-1319	256	31	will	will	AUX
dti-1319	256	32	have	have	VERB
dti-1319	256	33	less	less	ADV
dti-1319	256	34	undesired	undesired	ADJ
dti-1319	256	35	side	side	NOUN
dti-1319	256	36	effects	effect	NOUN
dti-1319	256	37	than	than	ADP
dti-1319	256	38	drugs	drug	NOUN
dti-1319	256	39	available	available	ADJ
dti-1319	256	40	today	today	NOUN
dti-1319	256	41	.	.	PUNCT
dti-1319	257	1	several	several	ADJ
dti-1319	257	2	studies	study	NOUN
dti-1319	257	3	have	have	AUX
dti-1319	257	4	shown	show	VERB
dti-1319	257	5	that	that	SCONJ
dti-1319	257	6	nanoparticles	nanoparticle	NOUN
dti-1319	257	7	can	can	AUX
dti-1319	257	8	be	be	AUX
dti-1319	257	9	attached	attach	VERB
dti-1319	257	10	to	to	PART
dti-1319	257	11	nas	nas	VERB
dti-1319	257	12	in	in	ADP
dti-1319	257	13	a	a	DET
dti-1319	257	14	way	way	NOUN
dti-1319	257	15	that	that	SCONJ
dti-1319	257	16	na	na	NOUN
dti-1319	257	17	-	-	ADJ
dti-1319	257	18	binding	bind	VERB
dti-1319	257	19	properties	property	NOUN
dti-1319	257	20	to	to	ADP
dti-1319	257	21	their	their	PRON
dti-1319	257	22	targets	target	NOUN
dti-1319	257	23	are	be	AUX
dti-1319	257	24	preserved	preserve	VERB
dti-1319	257	25	,	,	PUNCT
dti-1319	257	26	thus	thus	ADV
dti-1319	257	27	reducing	reduce	VERB
dti-1319	257	28	their	their	PRON
dti-1319	257	29	potentially	potentially	ADV
dti-1319	257	30	associated	associate	VERB
dti-1319	257	31	deleterious	deleterious	ADJ
dti-1319	257	32	side	side	NOUN
dti-1319	257	33	effects	effect	NOUN
dti-1319	257	34	.	.	PUNCT
dti-1319	258	1	these	these	DET
dti-1319	258	2	new	new	ADJ
dti-1319	258	3	approaches	approach	NOUN
dti-1319	258	4	can	can	AUX
dti-1319	258	5	supplement	supplement	VERB
dti-1319	258	6	the	the	DET
dti-1319	258	7	conventional	conventional	ADJ
dti-1319	258	8	chemotherapy	chemotherapy	NOUN
dti-1319	258	9	and	and	CCONJ
dti-1319	258	10	radiotherapy	radiotherapy	NOUN
dti-1319	258	11	in	in	ADP
dti-1319	258	12	cancer	cancer	NOUN
dti-1319	258	13	treatment	treatment	NOUN
dti-1319	258	14	,	,	PUNCT
dti-1319	258	15	prevent	prevent	VERB
dti-1319	258	16	drug	drug	NOUN
dti-1319	258	17	resistance	resistance	NOUN
dti-1319	258	18	and	and	CCONJ
dti-1319	258	19	damage	damage	NOUN
dti-1319	258	20	to	to	ADP
dti-1319	258	21	normal	normal	ADJ
dti-1319	258	22	tissues	tissue	NOUN
dti-1319	258	23	.	.	PUNCT
dti-1319	259	1	in	in	ADP
dti-1319	259	2	view	view	NOUN
dti-1319	259	3	of	of	ADP
dti-1319	259	4	the	the	DET
dti-1319	259	5	impact	impact	NOUN
dti-1319	259	6	of	of	ADP
dti-1319	259	7	the	the	DET
dti-1319	259	8	genomic	genomic	ADJ
dti-1319	259	9	revolution	revolution	NOUN
dti-1319	259	10	on	on	ADP
dti-1319	259	11	improving	improve	VERB
dti-1319	259	12	medicines	medicine	NOUN
dti-1319	259	13	and	and	CCONJ
dti-1319	259	14	healthcare	healthcare	NOUN
dti-1319	259	15	,	,	PUNCT
dti-1319	259	16	state	state	NOUN
dti-1319	259	17	-	-	PUNCT
dti-1319	259	18	of	of	ADP
dti-1319	259	19	-	-	PUNCT
dti-1319	259	20	theart	theart	NOUN
dti-1319	259	21	na	na	ADP
dti-1319	259	22	carriers	carrier	NOUN
dti-1319	259	23	together	together	ADV
dti-1319	259	24	with	with	ADP
dti-1319	259	25	highly	highly	ADV
dti-1319	259	26	specifi	specifi	PROPN
dti-1319	259	27	c	c	PROPN
dti-1319	259	28	oligonucleotide	oligonucleotide	NOUN
dti-1319	259	29	drugs	drug	NOUN
dti-1319	259	30	may	may	AUX
dti-1319	259	31	help	help	VERB
dti-1319	259	32	in	in	ADP
dti-1319	259	33	reducing	reduce	VERB
dti-1319	259	34	the	the	DET
dti-1319	259	35	side	side	NOUN
dti-1319	259	36	effects	effect	NOUN
dti-1319	259	37	of	of	ADP
dti-1319	259	38	drugs	drug	NOUN
dti-1319	259	39	during	during	ADP
dti-1319	259	40	therapy	therapy	NOUN
dti-1319	259	41	.	.	PUNCT
dti-1319	260	1	193	193	NUM
dti-1319	260	2	delivery	delivery	NOUN
dti-1319	260	3	systems	system	NOUN
dti-1319	260	4	of	of	ADP
dti-1319	260	5	nucleic	nucleic	ADJ
dti-1319	260	6	acids	acid	NOUN
dti-1319	260	7	drugs	drug	NOUN
dti-1319	260	8	drug	drug	NOUN
dti-1319	260	9	target	target	NOUN
dti-1319	260	10	insights	insight	VERB
dti-1319	260	11	2007:2	2007:2	NUM
dti-1319	260	12	acknowledgments	acknowledgment	NOUN
dti-1319	260	13	h.u	h.u	VERB
dti-1319	260	14	.	.	PUNCT
dti-1319	260	15	is	be	AUX
dti-1319	260	16	grateful	grateful	ADJ
dti-1319	260	17	for	for	ADP
dti-1319	260	18	grant	grant	NOUN
dti-1319	260	19	support	support	NOUN
dti-1319	260	20	from	from	ADP
dti-1319	260	21	fapesp	fapesp	ADJ
dti-1319	260	22	(	(	PUNCT
dti-1319	260	23	fundação	fundação	NOUN
dti-1319	260	24	de	de	X
dti-1319	260	25	amparo	amparo	PROPN
dti-1319	260	26	à	à	X
dti-1319	260	27	pesquisa	pesquisa	PROPN
dti-1319	260	28	do	do	AUX
dti-1319	260	29	estado	estado	PROPN
dti-1319	260	30	de	de	PROPN
dti-1319	260	31	são	são	PROPN
dti-1319	260	32	paulo	paulo	PROPN
dti-1319	260	33	)	)	PUNCT
dti-1319	260	34	and	and	CCONJ
dti-1319	260	35	cnpq	cnpq	NOUN
dti-1319	260	36	(	(	PUNCT
dti-1319	260	37	conselho	conselho	ADP
dti-1319	260	38	nacional	nacional	PROPN
dti-1319	260	39	de	de	X
dti-1319	260	40	desenvolvimento	desenvolvimento	PROPN
dti-1319	260	41	científico	científico	PROPN
dti-1319	260	42	e	e	PROPN
dti-1319	260	43	tecnologico	tecnologico	PROPN
dti-1319	260	44	)	)	PUNCT
dti-1319	260	45	,	,	PUNCT
dti-1319	260	46	brazil	brazil	PROPN
dti-1319	260	47	.	.	PUNCT
dti-1319	261	1	r.r.r	r.r.r	NOUN
dti-1319	261	2	.	.	PUNCT
dti-1319	262	1	ph.d	ph.d	PROPN
dti-1319	262	2	.	.	PUNCT
dti-1319	263	1	thesis	thesis	NOUN
dti-1319	263	2	was	be	AUX
dti-1319	263	3	supported	support	VERB
dti-1319	263	4	by	by	ADP
dti-1319	263	5	coordenação	coordenação	PROPN
dti-1319	263	6	de	de	PROPN
dti-1319	263	7	aperfeiçoamento	aperfeiçoamento	PROPN
dti-1319	263	8	de	de	X
dti-1319	263	9	pessoal	pessoal	PROPN
dti-1319	263	10	de	de	PROPN
dti-1319	263	11	nível	nível	PROPN
dti-1319	263	12	superior	superior	ADJ
dti-1319	263	13	(	(	PUNCT
dti-1319	263	14	capes	cape	NOUN
dti-1319	263	15	)	)	PUNCT
dti-1319	263	16	,	,	PUNCT
dti-1319	263	17	brazil	brazil	PROPN
dti-1319	263	18	,	,	PUNCT
dti-1319	263	19	and	and	CCONJ
dti-1319	263	20	his	his	PRON
dti-1319	263	21	post	post	ADJ
dti-1319	263	22	-	-	ADJ
dti-1319	263	23	doctoral	doctoral	ADJ
dti-1319	263	24	research	research	NOUN
dti-1319	263	25	is	be	AUX
dti-1319	263	26	currently	currently	ADV
dti-1319	263	27	supported	support	VERB
dti-1319	263	28	by	by	ADP
dti-1319	263	29	fapesp	fapesp	NOUN
dti-1319	263	30	.	.	PUNCT
dti-1319	264	1	h.a.t	h.a.t	PROPN
dti-1319	264	2	.	.	PROPN
dti-1319	264	3	is	be	AUX
dti-1319	264	4	supported	support	VERB
dti-1319	264	5	by	by	ADP
dti-1319	264	6	a	a	DET
dti-1319	264	7	fellowship	fellowship	NOUN
dti-1319	264	8	from	from	ADP
dti-1319	264	9	capes	cape	NOUN
dti-1319	264	10	.	.	PUNCT
dti-1319	265	1	k.k.y	k.k.y	PROPN
dti-1319	265	2	.	.	PROPN
dti-1319	265	3	’s	’s	PART
dti-1319	265	4	and	and	CCONJ
dti-1319	265	5	p.m.	p.m.	NOUN
dti-1319	265	6	’s	’s	PART
dti-1319	265	7	ph.d.theses	ph.d.these	NOUN
dti-1319	265	8	are	be	AUX
dti-1319	265	9	or	or	CCONJ
dti-1319	265	10	were	be	AUX
dti-1319	265	11	supported	support	VERB
dti-1319	265	12	by	by	ADP
dti-1319	265	13	fellowships	fellowship	NOUN
dti-1319	265	14	from	from	ADP
dti-1319	265	15	fapesp	fapesp	NOUN
dti-1319	265	16	.	.	PUNCT
dti-1319	266	1	references	reference	NOUN
dti-1319	266	2	ambati	ambati	PROPN
dti-1319	266	3	,	,	PUNCT
dti-1319	266	4	j.	j.	PROPN
dti-1319	266	5	,	,	PUNCT
dti-1319	266	6	canakis	canakis	PROPN
dti-1319	266	7	,	,	PUNCT
dti-1319	266	8	c.s	c.s	PROPN
dti-1319	266	9	.	.	PROPN
dti-1319	266	10	,	,	PUNCT
dti-1319	266	11	miller	miller	PROPN
dti-1319	266	12	,	,	PUNCT
dti-1319	266	13	j.w	j.w	PROPN
dti-1319	266	14	.	.	PROPN
dti-1319	266	15	,	,	PUNCT
dti-1319	266	16	et	et	PROPN
dti-1319	266	17	al	al	PROPN
dti-1319	266	18	.	.	PROPN
dti-1319	266	19	2000a	2000a	NOUN
dti-1319	266	20	.	.	PUNCT
dti-1319	267	1	diffusion	diffusion	NOUN
dti-1319	267	2	of	of	ADP
dti-1319	267	3	high	high	ADJ
dti-1319	267	4	molecular	molecular	ADJ
dti-1319	267	5	weight	weight	NOUN
dti-1319	267	6	compounds	compound	VERB
dti-1319	267	7	through	through	ADP
dti-1319	267	8	sclera	sclera	NOUN
dti-1319	267	9	.	.	PUNCT
dti-1319	268	1	invest	invest	VERB
dti-1319	268	2	ophthalmol	ophthalmol	PROPN
dti-1319	268	3	.	.	PUNCT
dti-1319	269	1	vis	vis	X
dti-1319	269	2	.	.	PUNCT
dti-1319	270	1	sci	sci	PROPN
dti-1319	270	2	.	.	PROPN
dti-1319	270	3	,	,	PUNCT
dti-1319	270	4	41:1181–5	41:1181–5	NUM
dti-1319	270	5	.	.	PUNCT
dti-1319	271	1	ambati	ambati	PROPN
dti-1319	271	2	,	,	PUNCT
dti-1319	271	3	j.	j.	PROPN
dti-1319	271	4	,	,	PUNCT
dti-1319	271	5	gragoudas	gragoudas	PROPN
dti-1319	271	6	,	,	PUNCT
dti-1319	271	7	e.s	e.s	PROPN
dti-1319	271	8	.	.	PROPN
dti-1319	271	9	,	,	PUNCT
dti-1319	271	10	miller	miller	PROPN
dti-1319	271	11	,	,	PUNCT
dti-1319	271	12	j.w	j.w	PROPN
dti-1319	271	13	.	.	PROPN
dti-1319	271	14	,	,	PUNCT
dti-1319	271	15	et	et	PROPN
dti-1319	271	16	al	al	PROPN
dti-1319	271	17	.	.	PROPN
dti-1319	271	18	2000b	2000b	NUM
dti-1319	271	19	.	.	PUNCT
dti-1319	272	1	transscleral	transscleral	ADJ
dti-1319	272	2	delivery	delivery	NOUN
dti-1319	272	3	of	of	ADP
dti-1319	272	4	bioactive	bioactive	ADJ
dti-1319	272	5	protein	protein	NOUN
dti-1319	272	6	to	to	ADP
dti-1319	272	7	the	the	DET
dti-1319	272	8	choroid	choroid	NOUN
dti-1319	272	9	and	and	CCONJ
dti-1319	272	10	retina	retina	VERB
dti-1319	272	11	.	.	PUNCT
dti-1319	273	1	invest	invest	VERB
dti-1319	273	2	ophthalmol	ophthalmol	PROPN
dti-1319	273	3	vis	vis	X
dti-1319	273	4	.	.	PUNCT
dti-1319	274	1	sci	sci	PROPN
dti-1319	274	2	.	.	PROPN
dti-1319	274	3	,	,	PUNCT
dti-1319	274	4	41:1186–91	41:1186–91	X
dti-1319	274	5	.	.	PUNCT
dti-1319	275	1	an	an	DET
dti-1319	275	2	,	,	PUNCT
dti-1319	275	3	c.i	c.i	PROPN
dti-1319	275	4	.	.	PROPN
dti-1319	275	5	,	,	PUNCT
dti-1319	275	6	trinh	trinh	PROPN
dti-1319	275	7	,	,	PUNCT
dti-1319	275	8	v.b	v.b	PROPN
dti-1319	275	9	.	.	PROPN
dti-1319	275	10	and	and	CCONJ
dti-1319	275	11	yokobayashi	yokobayashi	NUM
dti-1319	275	12	,	,	PUNCT
dti-1319	275	13	y.	y.	PROPN
dti-1319	275	14	2006	2006	NUM
dti-1319	275	15	.	.	PUNCT
dti-1319	276	1	artifi	artifi	PROPN
dti-1319	276	2	cial	cial	ADJ
dti-1319	276	3	control	control	NOUN
dti-1319	276	4	of	of	ADP
dti-1319	276	5	gene	gene	NOUN
dti-1319	276	6	expression	expression	NOUN
dti-1319	276	7	in	in	ADP
dti-1319	276	8	mammalian	mammalian	ADJ
dti-1319	276	9	cells	cell	NOUN
dti-1319	276	10	by	by	ADP
dti-1319	276	11	modulating	modulate	VERB
dti-1319	276	12	rna	rna	NOUN
dti-1319	276	13	interference	interference	NOUN
dti-1319	276	14	through	through	ADP
dti-1319	276	15	aptamer	aptamer	NOUN
dti-1319	276	16	-	-	PUNCT
dti-1319	276	17	small	small	ADJ
dti-1319	276	18	molecule	molecule	NOUN
dti-1319	276	19	interaction	interaction	NOUN
dti-1319	276	20	.	.	PUNCT
dti-1319	277	1	rna	rna	PROPN
dti-1319	277	2	,	,	PUNCT
dti-1319	277	3	12:710–6	12:710–6	NUM
dti-1319	277	4	.	.	PUNCT
dti-1319	278	1	bagga	bagga	PROPN
dti-1319	278	2	,	,	PUNCT
dti-1319	278	3	s.	s.	PROPN
dti-1319	278	4	,	,	PUNCT
dti-1319	278	5	bracht	bracht	PROPN
dti-1319	278	6	,	,	PUNCT
dti-1319	278	7	j.	j.	PROPN
dti-1319	278	8	,	,	PUNCT
dti-1319	278	9	hunter	hunter	NOUN
dti-1319	278	10	,	,	PUNCT
dti-1319	278	11	s.	s.	PROPN
dti-1319	278	12	,	,	PUNCT
dti-1319	278	13	et	et	PROPN
dti-1319	278	14	al	al	PROPN
dti-1319	278	15	.	.	PROPN
dti-1319	278	16	2005	2005	NUM
dti-1319	278	17	.	.	PUNCT
dti-1319	279	1	regulation	regulation	NOUN
dti-1319	279	2	by	by	ADP
dti-1319	279	3	let-7	let-7	PUNCT
dti-1319	279	4	and	and	CCONJ
dti-1319	279	5	lin-4	lin-4	DET
dti-1319	279	6	mirnas	mirna	NOUN
dti-1319	279	7	results	result	NOUN
dti-1319	279	8	in	in	ADP
dti-1319	279	9	target	target	NOUN
dti-1319	279	10	mrna	mrna	NOUN
dti-1319	279	11	degradation	degradation	NOUN
dti-1319	279	12	.	.	PUNCT
dti-1319	280	1	cell	cell	NOUN
dti-1319	280	2	,	,	PUNCT
dti-1319	280	3	122:553–63	122:553–63	NUM
dti-1319	280	4	.	.	PUNCT
dti-1319	281	1	bartel	bartel	PROPN
dti-1319	281	2	,	,	PUNCT
dti-1319	281	3	d.p	d.p	PROPN
dti-1319	281	4	.	.	PROPN
dti-1319	281	5	2004	2004	NUM
dti-1319	281	6	.	.	PUNCT
dti-1319	282	1	micrornas	microrna	NOUN
dti-1319	282	2	:	:	PUNCT
dti-1319	282	3	genomics	genomic	NOUN
dti-1319	282	4	,	,	PUNCT
dti-1319	282	5	biogenesis	biogenesis	NOUN
dti-1319	282	6	,	,	PUNCT
dti-1319	282	7	mechanism	mechanism	NOUN
dti-1319	282	8	,	,	PUNCT
dti-1319	282	9	and	and	CCONJ
dti-1319	282	10	function	function	NOUN
dti-1319	282	11	.	.	PUNCT
dti-1319	283	1	cell	cell	NOUN
dti-1319	283	2	,	,	PUNCT
dti-1319	283	3	116:281−97	116:281−97	PROPN
dti-1319	283	4	.	.	PUNCT
dti-1319	283	5	bernstein	bernstein	PROPN
dti-1319	283	6	,	,	PUNCT
dti-1319	283	7	e.	e.	PROPN
dti-1319	283	8	,	,	PUNCT
dti-1319	283	9	caudy	caudy	PROPN
dti-1319	283	10	,	,	PUNCT
dti-1319	283	11	a.a	a.a	PROPN
dti-1319	283	12	.	.	PROPN
dti-1319	283	13	,	,	PUNCT
dti-1319	283	14	hammond	hammond	PROPN
dti-1319	283	15	,	,	PUNCT
dti-1319	283	16	s.m	s.m	PROPN
dti-1319	283	17	.	.	PROPN
dti-1319	283	18	,	,	PUNCT
dti-1319	283	19	et	et	PROPN
dti-1319	283	20	al	al	PROPN
dti-1319	283	21	.	.	PROPN
dti-1319	283	22	2001	2001	NUM
dti-1319	283	23	.	.	PUNCT
dti-1319	284	1	role	role	NOUN
dti-1319	284	2	for	for	ADP
dti-1319	284	3	a	a	DET
dti-1319	284	4	bidentate	bidentate	NOUN
dti-1319	284	5	ribonuclease	ribonuclease	NOUN
dti-1319	284	6	in	in	ADP
dti-1319	284	7	the	the	DET
dti-1319	284	8	initiation	initiation	NOUN
dti-1319	284	9	step	step	NOUN
dti-1319	284	10	of	of	ADP
dti-1319	284	11	rna	rna	NOUN
dti-1319	284	12	interference	interference	NOUN
dti-1319	284	13	.	.	PUNCT
dti-1319	285	1	nature	nature	NOUN
dti-1319	285	2	,	,	PUNCT
dti-1319	285	3	409:363–6	409:363–6	NUM
dti-1319	285	4	.	.	PUNCT
dti-1319	286	1	bertrand	bertrand	PROPN
dti-1319	286	2	,	,	PUNCT
dti-1319	286	3	j.r	j.r	PROPN
dti-1319	286	4	.	.	PROPN
dti-1319	286	5	,	,	PUNCT
dti-1319	286	6	pottier	pottier	NOUN
dti-1319	286	7	,	,	PUNCT
dti-1319	286	8	m.	m.	NOUN
dti-1319	286	9	,	,	PUNCT
dti-1319	286	10	vekris	vekris	NOUN
dti-1319	286	11	,	,	PUNCT
dti-1319	286	12	a.	a.	NOUN
dti-1319	286	13	,	,	PUNCT
dti-1319	286	14	et	et	PROPN
dti-1319	286	15	al	al	PROPN
dti-1319	286	16	.	.	PROPN
dti-1319	286	17	2002	2002	NUM
dti-1319	286	18	.	.	PUNCT
dti-1319	287	1	comparison	comparison	NOUN
dti-1319	287	2	of	of	ADP
dti-1319	287	3	antisense	antisense	NOUN
dti-1319	287	4	oligonucleotides	oligonucleotide	NOUN
dti-1319	287	5	and	and	CCONJ
dti-1319	287	6	sirnas	sirna	NOUN
dti-1319	287	7	in	in	ADP
dti-1319	287	8	cell	cell	NOUN
dti-1319	287	9	culture	culture	NOUN
dti-1319	287	10	and	and	CCONJ
dti-1319	287	11	in	in	ADP
dti-1319	287	12	vivo	vivo	NOUN
dti-1319	287	13	.	.	PUNCT
dti-1319	288	1	biochem	biochem	PROPN
dti-1319	288	2	.	.	PUNCT
dti-1319	289	1	biophys	biophy	NOUN
dti-1319	289	2	.	.	PUNCT
dti-1319	290	1	res	re	NOUN
dti-1319	290	2	.	.	PUNCT
dti-1319	291	1	commun	commun	PROPN
dti-1319	291	2	.	.	PROPN
dti-1319	291	3	,	,	PUNCT
dti-1319	291	4	296:1000–4	296:1000–4	NUM
dti-1319	291	5	.	.	PUNCT
dti-1319	292	1	better	well	ADJ
dti-1319	292	2	,	,	PUNCT
dti-1319	292	3	m.	m.	NOUN
dti-1319	292	4	,	,	PUNCT
dti-1319	292	5	bernhard	bernhard	PROPN
dti-1319	292	6	,	,	PUNCT
dti-1319	292	7	s.l	s.l	PROPN
dti-1319	292	8	.	.	PROPN
dti-1319	292	9	,	,	PUNCT
dti-1319	292	10	fishwild	fishwild	PROPN
dti-1319	292	11	,	,	PUNCT
dti-1319	292	12	d.m	d.m	PROPN
dti-1319	292	13	.	.	PROPN
dti-1319	292	14	,	,	PUNCT
dti-1319	292	15	et	et	PROPN
dti-1319	292	16	al	al	PROPN
dti-1319	292	17	.	.	PROPN
dti-1319	292	18	1994	1994	NUM
dti-1319	292	19	.	.	PUNCT
dti-1319	293	1	gelonin	gelonin	PROPN
dti-1319	293	2	analogs	analog	NOUN
dti-1319	293	3	with	with	ADP
dti-1319	293	4	engineered	engineer	VERB
dti-1319	293	5	cysteine	cysteine	NOUN
dti-1319	293	6	residues	residue	NOUN
dti-1319	293	7	form	form	NOUN
dti-1319	293	8	antibody	antibody	NOUN
dti-1319	293	9	immunoconjugates	immunoconjugate	VERB
dti-1319	293	10	with	with	ADP
dti-1319	293	11	unique	unique	ADJ
dti-1319	293	12	properties	property	NOUN
dti-1319	293	13	.	.	PUNCT
dti-1319	294	1	j.	j.	PROPN
dti-1319	294	2	biol	biol	PROPN
dti-1319	294	3	.	.	PUNCT
dti-1319	295	1	chem	chem	PROPN
dti-1319	295	2	.	.	PUNCT
dti-1319	295	3	,	,	PUNCT
dti-1319	296	1	269:9644–50	269:9644–50	X
dti-1319	296	2	.	.	PUNCT
dti-1319	297	1	blank	blank	PROPN
dti-1319	297	2	,	,	PUNCT
dti-1319	297	3	m.	m.	NOUN
dti-1319	297	4	,	,	PUNCT
dti-1319	297	5	weinschenk	weinschenk	NOUN
dti-1319	297	6	,	,	PUNCT
dti-1319	297	7	t.	t.	PROPN
dti-1319	297	8	,	,	PUNCT
dti-1319	297	9	priemer	priemer	NOUN
dti-1319	297	10	,	,	PUNCT
dti-1319	297	11	m.	m.	NOUN
dti-1319	297	12	,	,	PUNCT
dti-1319	297	13	et	et	PROPN
dti-1319	297	14	al	al	PROPN
dti-1319	297	15	.	.	PROPN
dti-1319	297	16	2001	2001	NUM
dti-1319	297	17	.	.	PUNCT
dti-1319	298	1	systematic	systematic	ADJ
dti-1319	298	2	evolution	evolution	NOUN
dti-1319	298	3	of	of	ADP
dti-1319	298	4	a	a	DET
dti-1319	298	5	dna	dna	NOUN
dti-1319	298	6	aptamer	aptamer	NOUN
dti-1319	298	7	binding	bind	VERB
dti-1319	298	8	to	to	ADP
dti-1319	298	9	rat	rat	NOUN
dti-1319	298	10	brain	brain	NOUN
dti-1319	298	11	tumor	tumor	NOUN
dti-1319	298	12	microvessels	microvessel	NOUN
dti-1319	298	13	.	.	PUNCT
dti-1319	299	1	selective	selective	ADJ
dti-1319	299	2	targeting	targeting	NOUN
dti-1319	299	3	of	of	ADP
dti-1319	299	4	endothelial	endothelial	ADJ
dti-1319	299	5	regulatory	regulatory	ADJ
dti-1319	299	6	protein	protein	NOUN
dti-1319	299	7	pigpen	pigpen	NOUN
dti-1319	299	8	.	.	PUNCT
dti-1319	300	1	j.	j.	PROPN
dti-1319	300	2	biol	biol	PROPN
dti-1319	300	3	.	.	PUNCT
dti-1319	301	1	chem	chem	PROPN
dti-1319	301	2	.	.	PUNCT
dti-1319	301	3	,	,	PUNCT
dti-1319	301	4	276:16464–8	276:16464–8	NUM
dti-1319	301	5	.	.	PUNCT
dti-1319	302	1	blind	blind	ADJ
dti-1319	302	2	,	,	PUNCT
dti-1319	302	3	m.	m.	NOUN
dti-1319	302	4	,	,	PUNCT
dti-1319	302	5	kolanus	kolanus	PROPN
dti-1319	302	6	,	,	PUNCT
dti-1319	302	7	w.	w.	PROPN
dti-1319	302	8	and	and	CCONJ
dti-1319	302	9	famulok	famulok	PROPN
dti-1319	302	10	,	,	PUNCT
dti-1319	302	11	m.	m.	NOUN
dti-1319	302	12	1999	1999	NUM
dti-1319	302	13	.	.	PUNCT
dti-1319	303	1	cytoplasmic	cytoplasmic	ADJ
dti-1319	303	2	rna	rna	NOUN
dti-1319	303	3	modulators	modulator	NOUN
dti-1319	303	4	of	of	ADP
dti-1319	303	5	an	an	DET
dti-1319	303	6	inside	inside	NOUN
dti-1319	303	7	-	-	PUNCT
dti-1319	303	8	out	out	ADP
dti-1319	303	9	signal	signal	NOUN
dti-1319	303	10	-	-	PUNCT
dti-1319	303	11	transduction	transduction	NOUN
dti-1319	303	12	cascade	cascade	NOUN
dti-1319	303	13	.	.	PUNCT
dti-1319	304	1	proc	proc	PROPN
dti-1319	304	2	.	.	PUNCT
dti-1319	305	1	natl	natl	PROPN
dti-1319	305	2	.	.	PUNCT
dti-1319	306	1	acad	acad	PROPN
dti-1319	306	2	.	.	PUNCT
dti-1319	307	1	sci	sci	PROPN
dti-1319	307	2	.	.	PUNCT
dti-1319	307	3	u.s.a	u.s.a	PROPN
dti-1319	307	4	.	.	PROPN
dti-1319	307	5	,	,	PUNCT
dti-1319	307	6	96:3606–10	96:3606–10	NUM
dti-1319	307	7	.	.	PUNCT
dti-1319	308	1	boubriak	boubriak	PROPN
dti-1319	308	2	,	,	PUNCT
dti-1319	308	3	o.a	o.a	PROPN
dti-1319	308	4	.	.	PROPN
dti-1319	308	5	,	,	PUNCT
dti-1319	308	6	urban	urban	ADJ
dti-1319	308	7	,	,	PUNCT
dti-1319	308	8	j.p.g	j.p.g	PROPN
dti-1319	308	9	.	.	PROPN
dti-1319	308	10	,	,	PUNCT
dti-1319	308	11	akhtar	akhtar	PROPN
dti-1319	308	12	,	,	PUNCT
dti-1319	308	13	k.m	k.m	PROPN
dti-1319	308	14	.	.	PROPN
dti-1319	308	15	,	,	PUNCT
dti-1319	308	16	et	et	PROPN
dti-1319	308	17	al	al	PROPN
dti-1319	308	18	.	.	PROPN
dti-1319	308	19	2000	2000	NUM
dti-1319	308	20	.	.	PUNCT
dti-1319	309	1	the	the	DET
dti-1319	309	2	effect	effect	NOUN
dti-1319	309	3	of	of	ADP
dti-1319	309	4	hydration	hydration	NOUN
dti-1319	309	5	and	and	CCONJ
dti-1319	309	6	matrix	matrix	NOUN
dti-1319	309	7	composition	composition	NOUN
dti-1319	309	8	on	on	ADP
dti-1319	309	9	solute	solute	ADJ
dti-1319	309	10	diffusion	diffusion	NOUN
dti-1319	309	11	in	in	ADP
dti-1319	309	12	rabbit	rabbit	NOUN
dti-1319	309	13	sclera	sclera	NOUN
dti-1319	309	14	.	.	PUNCT
dti-1319	310	1	exp	exp	NOUN
dti-1319	310	2	.	.	PUNCT
dti-1319	310	3	eye	eye	NOUN
dti-1319	310	4	res	re	NOUN
dti-1319	310	5	.	.	PUNCT
dti-1319	310	6	,	,	PUNCT
dti-1319	310	7	71:503–14	71:503–14	PROPN
dti-1319	310	8	.	.	PUNCT
dti-1319	311	1	bruno	bruno	PROPN
dti-1319	311	2	,	,	PUNCT
dti-1319	311	3	j.g	j.g	PROPN
dti-1319	311	4	.	.	PROPN
dti-1319	311	5	and	and	CCONJ
dti-1319	311	6	kiel	kiel	PROPN
dti-1319	311	7	,	,	PUNCT
dti-1319	311	8	j.l	j.l	PROPN
dti-1319	311	9	.	.	PROPN
dti-1319	311	10	1999	1999	NUM
dti-1319	311	11	.	.	PUNCT
dti-1319	312	1	in	in	ADP
dti-1319	312	2	vitro	vitro	X
dti-1319	312	3	selection	selection	NOUN
dti-1319	312	4	of	of	ADP
dti-1319	312	5	dna	dna	PROPN
dti-1319	312	6	aptamers	aptamer	NOUN
dti-1319	312	7	to	to	ADP
dti-1319	312	8	anthrax	anthrax	NOUN
dti-1319	312	9	spores	spore	NOUN
dti-1319	312	10	with	with	ADP
dti-1319	312	11	electrochemiluminescence	electrochemiluminescence	NOUN
dti-1319	312	12	detection	detection	NOUN
dti-1319	312	13	.	.	PUNCT
dti-1319	313	1	biosens	biosen	NOUN
dti-1319	313	2	.	.	PUNCT
dti-1319	314	1	bioelectron	bioelectron	PROPN
dti-1319	314	2	.	.	PROPN
dti-1319	314	3	,	,	PUNCT
dti-1319	314	4	14:457–64	14:457–64	NUM
dti-1319	314	5	.	.	PUNCT
dti-1319	315	1	cao	cao	PROPN
dti-1319	315	2	,	,	PUNCT
dti-1319	315	3	l.	l.	PROPN
dti-1319	315	4	,	,	PUNCT
dti-1319	315	5	jiao	jiao	PROPN
dti-1319	315	6	,	,	PUNCT
dti-1319	315	7	x.	x.	PROPN
dti-1319	315	8	,	,	PUNCT
dti-1319	315	9	zuzga	zuzga	PROPN
dti-1319	315	10	,	,	PUNCT
dti-1319	315	11	d.s	d.s	PROPN
dti-1319	315	12	.	.	PROPN
dti-1319	315	13	,	,	PUNCT
dti-1319	315	14	et	et	PROPN
dti-1319	315	15	al	al	PROPN
dti-1319	315	16	.	.	PROPN
dti-1319	315	17	2004	2004	NUM
dti-1319	315	18	.	.	PUNCT
dti-1319	316	1	vegf	vegf	NOUN
dti-1319	316	2	links	link	NOUN
dti-1319	316	3	hippocampal	hippocampal	VERB
dti-1319	316	4	activity	activity	NOUN
dti-1319	316	5	with	with	ADP
dti-1319	316	6	neurogenesis	neurogenesis	NOUN
dti-1319	316	7	,	,	PUNCT
dti-1319	316	8	learning	learning	NOUN
dti-1319	316	9	and	and	CCONJ
dti-1319	316	10	memory	memory	NOUN
dti-1319	316	11	.	.	PUNCT
dti-1319	317	1	nat	nat	PROPN
dti-1319	317	2	.	.	PUNCT
dti-1319	318	1	genet	genet	PROPN
dti-1319	318	2	.	.	PUNCT
dti-1319	318	3	,	,	PUNCT
dti-1319	318	4	36:827–35	36:827–35	VERB
dti-1319	318	5	.	.	PUNCT
dti-1319	319	1	carrasquillo	carrasquillo	PROPN
dti-1319	319	2	,	,	PUNCT
dti-1319	319	3	k.g	k.g	PROPN
dti-1319	319	4	.	.	PROPN
dti-1319	319	5	,	,	PUNCT
dti-1319	319	6	carro	carro	PROPN
dti-1319	319	7	,	,	PUNCT
dti-1319	319	8	j.c	j.c	PROPN
dti-1319	319	9	.	.	PROPN
dti-1319	319	10	,	,	PUNCT
dti-1319	319	11	alejandro	alejandro	PROPN
dti-1319	319	12	,	,	PUNCT
dti-1319	319	13	a.	a.	PROPN
dti-1319	319	14	,	,	PUNCT
dti-1319	319	15	et	et	PROPN
dti-1319	319	16	al	al	PROPN
dti-1319	319	17	.	.	PROPN
dti-1319	319	18	2001a	2001a	NOUN
dti-1319	319	19	.	.	PUNCT
dti-1319	320	1	reduction	reduction	NOUN
dti-1319	320	2	of	of	ADP
dti-1319	320	3	structural	structural	ADJ
dti-1319	320	4	perturbations	perturbation	NOUN
dti-1319	320	5	in	in	ADP
dti-1319	320	6	bovine	bovine	NOUN
dti-1319	320	7	serum	serum	NOUN
dti-1319	320	8	albumin	albumin	NOUN
dti-1319	320	9	by	by	ADP
dti-1319	320	10	non	non	ADJ
dti-1319	320	11	-	-	ADJ
dti-1319	320	12	aqueous	aqueous	ADJ
dti-1319	320	13	microencapsulation	microencapsulation	NOUN
dti-1319	320	14	.	.	PUNCT
dti-1319	321	1	j	j	PROPN
dti-1319	321	2	pharm	pharm	PROPN
dti-1319	321	3	.	.	PUNCT
dti-1319	322	1	pharmacol	pharmacol	PROPN
dti-1319	322	2	.	.	PROPN
dti-1319	322	3	,	,	PUNCT
dti-1319	322	4	53:115–20	53:115–20	NUM
dti-1319	322	5	.	.	PUNCT
dti-1319	323	1	carrasquillo	carrasquillo	PROPN
dti-1319	323	2	,	,	PUNCT
dti-1319	323	3	k.g	k.g	PROPN
dti-1319	323	4	.	.	PROPN
dti-1319	323	5	,	,	PUNCT
dti-1319	323	6	costantino	costantino	PROPN
dti-1319	323	7	,	,	PUNCT
dti-1319	323	8	h.r	h.r	PROPN
dti-1319	323	9	.	.	PROPN
dti-1319	323	10	,	,	PUNCT
dti-1319	323	11	cordero	cordero	PROPN
dti-1319	323	12	,	,	PUNCT
dti-1319	323	13	r.a	r.a	PROPN
dti-1319	323	14	.	.	PROPN
dti-1319	323	15	,	,	PUNCT
dti-1319	323	16	et	et	PROPN
dti-1319	323	17	al	al	PROPN
dti-1319	323	18	.	.	PROPN
dti-1319	323	19	1999	1999	NUM
dti-1319	323	20	.	.	PUNCT
dti-1319	324	1	on	on	ADP
dti-1319	324	2	the	the	DET
dti-1319	324	3	structural	structural	ADJ
dti-1319	324	4	preservation	preservation	NOUN
dti-1319	324	5	of	of	ADP
dti-1319	324	6	recombinant	recombinant	ADJ
dti-1319	324	7	human	human	ADJ
dti-1319	324	8	growth	growth	NOUN
dti-1319	324	9	hormone	hormone	NOUN
dti-1319	324	10	in	in	ADP
dti-1319	324	11	a	a	DET
dti-1319	324	12	dried	dry	VERB
dti-1319	324	13	fi	fi	NOUN
dti-1319	324	14	lm	lm	INTJ
dti-1319	324	15	of	of	ADP
dti-1319	324	16	a	a	DET
dti-1319	324	17	synthetic	synthetic	ADJ
dti-1319	324	18	biodegradable	biodegradable	ADJ
dti-1319	324	19	polymer	polymer	NOUN
dti-1319	324	20	.	.	PUNCT
dti-1319	325	1	j	j	PROPN
dti-1319	325	2	pharm	pharm	PROPN
dti-1319	325	3	.	.	PUNCT
dti-1319	326	1	sci	sci	PROPN
dti-1319	326	2	.	.	PROPN
dti-1319	326	3	,	,	PUNCT
dti-1319	326	4	88:166–73	88:166–73	ADV
dti-1319	326	5	.	.	PUNCT
dti-1319	327	1	carrasquillo	carrasquillo	PROPN
dti-1319	327	2	,	,	PUNCT
dti-1319	327	3	k.g	k.g	PROPN
dti-1319	327	4	.	.	PROPN
dti-1319	327	5	,	,	PUNCT
dti-1319	327	6	ricker	ricker	PROPN
dti-1319	327	7	,	,	PUNCT
dti-1319	327	8	j.a	j.a	PROPN
dti-1319	327	9	.	.	PROPN
dti-1319	327	10	,	,	PUNCT
dti-1319	327	11	rigas	rigas	PROPN
dti-1319	327	12	,	,	PUNCT
dti-1319	327	13	i.k	i.k	PROPN
dti-1319	327	14	.	.	PROPN
dti-1319	327	15	,	,	PUNCT
dti-1319	327	16	et	et	PROPN
dti-1319	327	17	al	al	PROPN
dti-1319	327	18	.	.	PROPN
dti-1319	327	19	2003	2003	NUM
dti-1319	327	20	.	.	PUNCT
dti-1319	328	1	controlled	control	VERB
dti-1319	328	2	delivery	delivery	NOUN
dti-1319	328	3	of	of	ADP
dti-1319	328	4	the	the	DET
dti-1319	328	5	anti	anti	ADJ
dti-1319	328	6	-	-	ADJ
dti-1319	328	7	vegf	vegf	ADJ
dti-1319	328	8	aptamer	aptamer	NOUN
dti-1319	328	9	eye001	eye001	PROPN
dti-1319	328	10	with	with	ADP
dti-1319	328	11	poly(lactic	poly(lactic	PROPN
dti-1319	328	12	-	-	PUNCT
dti-1319	328	13	co	co	NOUN
dti-1319	328	14	-	-	ADJ
dti-1319	328	15	glycolic)acid	glycolic)acid	ADJ
dti-1319	328	16	microspheres	microsphere	NOUN
dti-1319	328	17	.	.	PUNCT
dti-1319	329	1	invest	invest	VERB
dti-1319	329	2	ophthalmol	ophthalmol	PROPN
dti-1319	329	3	vis	vis	X
dti-1319	329	4	.	.	PUNCT
dti-1319	330	1	sci	sci	PROPN
dti-1319	330	2	.	.	PROPN
dti-1319	330	3	,	,	PUNCT
dti-1319	330	4	44:290–9	44:290–9	NUM
dti-1319	330	5	.	.	PUNCT
dti-1319	331	1	carrasquillo	carrasquillo	PROPN
dti-1319	331	2	,	,	PUNCT
dti-1319	331	3	k.g	k.g	PROPN
dti-1319	331	4	.	.	PROPN
dti-1319	331	5	,	,	PUNCT
dti-1319	331	6	stanley	stanley	PROPN
dti-1319	331	7	,	,	PUNCT
dti-1319	331	8	a.m.	a.m.	ADV
dti-1319	331	9	,	,	PUNCT
dti-1319	331	10	aponte	aponte	PROPN
dti-1319	331	11	,	,	PUNCT
dti-1319	331	12	j.c	j.c	PROPN
dti-1319	331	13	.	.	PROPN
dti-1319	331	14	,	,	PUNCT
dti-1319	331	15	et	et	PROPN
dti-1319	331	16	al	al	PROPN
dti-1319	331	17	.	.	PROPN
dti-1319	331	18	2001b	2001b	NUM
dti-1319	331	19	.	.	PUNCT
dti-1319	332	1	non	non	ADJ
dti-1319	332	2	-	-	ADJ
dti-1319	332	3	aqueous	aqueous	ADJ
dti-1319	332	4	encapsulation	encapsulation	NOUN
dti-1319	332	5	of	of	ADP
dti-1319	332	6	excipient	excipient	NOUN
dti-1319	332	7	-	-	PUNCT
dti-1319	332	8	stabilized	stabilize	VERB
dti-1319	332	9	spray	spray	NOUN
dti-1319	332	10	freeze	freeze	NOUN
dti-1319	332	11	-	-	PUNCT
dti-1319	332	12	dried	dry	VERB
dti-1319	332	13	bsa	bsa	NOUN
dti-1319	332	14	into	into	ADP
dti-1319	332	15	poly	poly	ADJ
dti-1319	332	16	(	(	PUNCT
dti-1319	332	17	lactide	lactide	ADV
dti-1319	332	18	-	-	PUNCT
dti-1319	332	19	co	co	NOUN
dti-1319	332	20	-	-	ADJ
dti-1319	332	21	glycolide	glycolide	ADJ
dti-1319	332	22	)	)	PUNCT
dti-1319	332	23	microspheres	microsphere	VERB
dti-1319	332	24	results	result	NOUN
dti-1319	332	25	in	in	ADP
dti-1319	332	26	release	release	NOUN
dti-1319	332	27	of	of	ADP
dti-1319	332	28	native	native	ADJ
dti-1319	332	29	protein	protein	NOUN
dti-1319	332	30	.	.	PUNCT
dti-1319	333	1	j.	j.	PROPN
dti-1319	333	2	control	control	PROPN
dti-1319	333	3	release	release	PROPN
dti-1319	333	4	,	,	PUNCT
dti-1319	333	5	76:199–208	76:199–208	PROPN
dti-1319	333	6	.	.	PUNCT
dti-1319	333	7	chaloin	chaloin	PROPN
dti-1319	333	8	,	,	PUNCT
dti-1319	333	9	l.	l.	PROPN
dti-1319	333	10	,	,	PUNCT
dti-1319	333	11	lehmann	lehmann	PROPN
dti-1319	333	12	,	,	PUNCT
dti-1319	333	13	m.j	m.j	PROPN
dti-1319	333	14	.	.	PROPN
dti-1319	333	15	,	,	PUNCT
dti-1319	333	16	sczakiel	sczakiel	PROPN
dti-1319	333	17	,	,	PUNCT
dti-1319	333	18	g.	g.	PROPN
dti-1319	333	19	,	,	PUNCT
dti-1319	333	20	et	et	PROPN
dti-1319	333	21	al	al	PROPN
dti-1319	333	22	.	.	PROPN
dti-1319	333	23	2002	2002	NUM
dti-1319	333	24	.	.	PUNCT
dti-1319	334	1	endogenous	endogenous	ADJ
dti-1319	334	2	expression	expression	NOUN
dti-1319	334	3	of	of	ADP
dti-1319	334	4	a	a	DET
dti-1319	334	5	high	high	ADJ
dti-1319	334	6	-	-	PUNCT
dti-1319	334	7	affi	affi	NOUN
dti-1319	334	8	nity	nity	NOUN
dti-1319	334	9	pseudoknot	pseudoknot	ADV
dti-1319	334	10	rna	rna	PROPN
dti-1319	334	11	aptamer	aptamer	NOUN
dti-1319	334	12	suppresses	suppress	VERB
dti-1319	334	13	replication	replication	NOUN
dti-1319	334	14	of	of	ADP
dti-1319	334	15	hiv-1	hiv-1	X
dti-1319	334	16	.	.	PUNCT
dti-1319	335	1	nucleic	nucleic	ADJ
dti-1319	335	2	acids	acid	NOUN
dti-1319	335	3	res	re	NOUN
dti-1319	335	4	.	.	PUNCT
dti-1319	335	5	,	,	PUNCT
dti-1319	335	6	30:4001–8	30:4001–8	NUM
dti-1319	335	7	.	.	PUNCT
dti-1319	336	1	chen	chen	PROPN
dti-1319	336	2	,	,	PUNCT
dti-1319	336	3	y.	y.	PROPN
dti-1319	336	4	,	,	PUNCT
dti-1319	336	5	chen	chen	PROPN
dti-1319	336	6	,	,	PUNCT
dti-1319	336	7	h.	h.	PROPN
dti-1319	336	8	,	,	PUNCT
dti-1319	336	9	hoffmann	hoffmann	PROPN
dti-1319	336	10	,	,	PUNCT
dti-1319	336	11	a.	a.	PROPN
dti-1319	336	12	,	,	PUNCT
dti-1319	336	13	et	et	PROPN
dti-1319	336	14	al	al	PROPN
dti-1319	336	15	.	.	PROPN
dti-1319	336	16	2006	2006	NUM
dti-1319	336	17	adenovirus	adenovirus	NOUN
dti-1319	336	18	-	-	PUNCT
dti-1319	336	19	mediated	mediate	VERB
dti-1319	336	20	smallinterference	smallinterference	NOUN
dti-1319	336	21	rna	rna	NOUN
dti-1319	336	22	for	for	ADP
dti-1319	336	23	in	in	ADP
dti-1319	336	24	vivo	vivo	ADJ
dti-1319	336	25	silencing	silencing	NOUN
dti-1319	336	26	of	of	ADP
dti-1319	336	27	angiotensin	angiotensin	NOUN
dti-1319	336	28	at1a	at1a	DET
dti-1319	336	29	receptors	receptor	NOUN
dti-1319	336	30	in	in	ADP
dti-1319	336	31	mouse	mouse	NOUN
dti-1319	336	32	brain	brain	NOUN
dti-1319	336	33	.	.	PUNCT
dti-1319	337	1	hypertension	hypertension	NOUN
dti-1319	337	2	,	,	PUNCT
dti-1319	337	3	47	47	NUM
dti-1319	337	4	,	,	PUNCT
dti-1319	337	5	230–37	230–37	PROPN
dti-1319	337	6	.	.	PUNCT
dti-1319	338	1	choung	choung	PROPN
dti-1319	338	2	,	,	PUNCT
dti-1319	338	3	s.	s.	PROPN
dti-1319	338	4	,	,	PUNCT
dti-1319	338	5	kim	kim	PROPN
dti-1319	338	6	,	,	PUNCT
dti-1319	338	7	y.j	y.j	PROPN
dti-1319	338	8	.	.	PROPN
dti-1319	338	9	,	,	PUNCT
dti-1319	338	10	kim	kim	PROPN
dti-1319	338	11	,	,	PUNCT
dti-1319	338	12	s.	s.	PROPN
dti-1319	338	13	,	,	PUNCT
dti-1319	338	14	et	et	PROPN
dti-1319	338	15	al	al	PROPN
dti-1319	338	16	.	.	PROPN
dti-1319	338	17	2006	2006	NUM
dti-1319	338	18	.	.	PUNCT
dti-1319	339	1	chemical	chemical	PROPN
dti-1319	339	2	modifi	modifi	PROPN
dti-1319	339	3	cation	cation	NOUN
dti-1319	339	4	of	of	ADP
dti-1319	339	5	sirnas	sirna	NOUN
dti-1319	339	6	to	to	PART
dti-1319	339	7	improve	improve	VERB
dti-1319	339	8	serum	serum	NOUN
dti-1319	339	9	stability	stability	NOUN
dti-1319	339	10	without	without	ADP
dti-1319	339	11	loss	loss	NOUN
dti-1319	339	12	of	of	ADP
dti-1319	339	13	effi	effi	PROPN
dti-1319	339	14	cacy	cacy	PROPN
dti-1319	339	15	.	.	PUNCT
dti-1319	340	1	biochem	biochem	PROPN
dti-1319	340	2	.	.	PUNCT
dti-1319	341	1	biophys	biophy	NOUN
dti-1319	341	2	.	.	PUNCT
dti-1319	342	1	res	re	NOUN
dti-1319	342	2	.	.	PUNCT
dti-1319	343	1	commun	commun	PROPN
dti-1319	343	2	.	.	PROPN
dti-1319	343	3	,	,	PUNCT
dti-1319	343	4	342:919–27	342:919–27	NUM
dti-1319	343	5	.	.	PUNCT
dti-1319	344	1	chu	chu	PROPN
dti-1319	344	2	,	,	PUNCT
dti-1319	344	3	t.c	t.c	PROPN
dti-1319	344	4	.	.	PROPN
dti-1319	344	5	,	,	PUNCT
dti-1319	344	6	marks	marks	PROPN
dti-1319	344	7	,	,	PUNCT
dti-1319	344	8	j.w	j.w	PROPN
dti-1319	344	9	.	.	PROPN
dti-1319	344	10	,	,	PUNCT
dti-1319	344	11	3rd	3rd	NOUN
dti-1319	344	12	,	,	PUNCT
dti-1319	344	13	lavery	lavery	PROPN
dti-1319	344	14	,	,	PUNCT
dti-1319	344	15	l.a	l.a	PROPN
dti-1319	344	16	.	.	PROPN
dti-1319	344	17	,	,	PUNCT
dti-1319	344	18	et	et	PROPN
dti-1319	344	19	al	al	PROPN
dti-1319	344	20	.	.	PROPN
dti-1319	344	21	2006	2006	NUM
dti-1319	344	22	.	.	PUNCT
dti-1319	345	1	aptamer	aptamer	NOUN
dti-1319	345	2	:	:	PUNCT
dti-1319	345	3	toxin	toxin	NOUN
dti-1319	345	4	conjugates	conjugate	NOUN
dti-1319	345	5	that	that	PRON
dti-1319	345	6	specifi	specifi	VERB
dti-1319	345	7	cally	cally	ADV
dti-1319	345	8	target	target	VERB
dti-1319	345	9	prostate	prostate	NOUN
dti-1319	345	10	tumor	tumor	NOUN
dti-1319	345	11	cells	cell	NOUN
dti-1319	345	12	.	.	PUNCT
dti-1319	346	1	cancer	cancer	NOUN
dti-1319	346	2	res	re	NOUN
dti-1319	346	3	.	.	PROPN
dti-1319	346	4	,	,	PUNCT
dti-1319	346	5	66:5989–92	66:5989–92	NUM
dti-1319	346	6	.	.	PUNCT
dti-1319	347	1	cory	cory	PROPN
dti-1319	347	2	,	,	PUNCT
dti-1319	347	3	s.	s.	PROPN
dti-1319	347	4	and	and	CCONJ
dti-1319	347	5	adams	adams	PROPN
dti-1319	347	6	,	,	PUNCT
dti-1319	347	7	j.m	j.m	PROPN
dti-1319	347	8	.	.	PROPN
dti-1319	347	9	2005	2005	NUM
dti-1319	347	10	.	.	PUNCT
dti-1319	348	1	killing	kill	VERB
dti-1319	348	2	cancer	cancer	NOUN
dti-1319	348	3	cells	cell	NOUN
dti-1319	348	4	by	by	ADP
dti-1319	348	5	fl	fl	X
dti-1319	348	6	ipping	ippe	VERB
dti-1319	348	7	the	the	DET
dti-1319	348	8	bcl2	bcl2	PROPN
dti-1319	348	9	/	/	SYM
dti-1319	348	10	bax	bax	PROPN
dti-1319	348	11	switch	switch	NOUN
dti-1319	348	12	.	.	PUNCT
dti-1319	349	1	cancer	cancer	NOUN
dti-1319	349	2	cell	cell	NOUN
dti-1319	349	3	,	,	PUNCT
dti-1319	349	4	8:5–6	8:5–6	NUM
dti-1319	349	5	.	.	PUNCT
dti-1319	350	1	crooke	crooke	PROPN
dti-1319	350	2	,	,	PUNCT
dti-1319	350	3	s.t	s.t	PROPN
dti-1319	350	4	.	.	PROPN
dti-1319	350	5	1998	1998	NUM
dti-1319	350	6	.	.	PUNCT
dti-1319	351	1	an	an	DET
dti-1319	351	2	overview	overview	NOUN
dti-1319	351	3	of	of	ADP
dti-1319	351	4	progress	progress	NOUN
dti-1319	351	5	in	in	ADP
dti-1319	351	6	antisense	antisense	NOUN
dti-1319	351	7	therapeutics	therapeutic	NOUN
dti-1319	351	8	.	.	PUNCT
dti-1319	352	1	antisense	antisense	NOUN
dti-1319	352	2	nucleic	nucleic	ADJ
dti-1319	352	3	acid	acid	NOUN
dti-1319	352	4	.	.	PUNCT
dti-1319	353	1	drug	drug	PROPN
dti-1319	353	2	dev	dev	PROPN
dti-1319	353	3	.	.	PROPN
dti-1319	353	4	,	,	PUNCT
dti-1319	353	5	8:115–22	8:115–22	PROPN
dti-1319	353	6	.	.	PUNCT
dti-1319	354	1	dande	dande	NOUN
dti-1319	354	2	,	,	PUNCT
dti-1319	354	3	p.	p.	NOUN
dti-1319	354	4	,	,	PUNCT
dti-1319	354	5	prakash	prakash	PROPN
dti-1319	354	6	,	,	PUNCT
dti-1319	354	7	t.p	t.p	PROPN
dti-1319	354	8	.	.	PROPN
dti-1319	354	9	,	,	PUNCT
dti-1319	354	10	sioufi	sioufi	NOUN
dti-1319	354	11	,	,	PUNCT
dti-1319	354	12	n.	n.	PROPN
dti-1319	354	13	,	,	PUNCT
dti-1319	354	14	et	et	PROPN
dti-1319	354	15	al	al	PROPN
dti-1319	354	16	.	.	PROPN
dti-1319	354	17	2006	2006	NUM
dti-1319	354	18	.	.	PUNCT
dti-1319	355	1	improving	improve	VERB
dti-1319	355	2	rna	rna	NOUN
dti-1319	355	3	interference	interference	NOUN
dti-1319	355	4	in	in	ADP
dti-1319	355	5	mammalian	mammalian	ADJ
dti-1319	355	6	cells	cell	NOUN
dti-1319	355	7	by	by	ADP
dti-1319	355	8	4’-thio	4’-thio	NUM
dti-1319	355	9	-	-	PUNCT
dti-1319	355	10	modifi	modifi	NOUN
dti-1319	355	11	ed	ed	PROPN
dti-1319	355	12	small	small	ADJ
dti-1319	355	13	interfering	interfere	VERB
dti-1319	355	14	rna	rna	PROPN
dti-1319	355	15	(	(	PUNCT
dti-1319	355	16	sirna	sirna	PROPN
dti-1319	355	17	):	):	PUNCT
dti-1319	355	18	effect	effect	NOUN
dti-1319	355	19	on	on	ADP
dti-1319	355	20	sirna	sirna	PROPN
dti-1319	355	21	activity	activity	NOUN
dti-1319	355	22	and	and	CCONJ
dti-1319	355	23	nuclease	nuclease	NOUN
dti-1319	355	24	stability	stability	NOUN
dti-1319	355	25	when	when	SCONJ
dti-1319	355	26	used	use	VERB
dti-1319	355	27	in	in	ADP
dti-1319	355	28	combination	combination	NOUN
dti-1319	355	29	with	with	ADP
dti-1319	355	30	2’-o	2’-o	NOUN
dti-1319	355	31	-	-	ADJ
dti-1319	355	32	alkyl	alkyl	ADJ
dti-1319	355	33	modifications	modification	NOUN
dti-1319	355	34	.	.	PUNCT
dti-1319	356	1	j.	j.	PROPN
dti-1319	356	2	med	med	PROPN
dti-1319	356	3	.	.	PROPN
dti-1319	356	4	chem	chem	PROPN
dti-1319	356	5	.	.	PUNCT
dti-1319	356	6	,	,	PUNCT
dti-1319	356	7	49:1624–34	49:1624–34	X
dti-1319	356	8	.	.	PUNCT
dti-1319	356	9	danis	danis	PROPN
dti-1319	356	10	,	,	PUNCT
dti-1319	356	11	m.	m.	NOUN
dti-1319	356	12	2003	2003	NUM
dti-1319	356	13	.	.	PUNCT
dti-1319	357	1	therapeutic	therapeutic	ADJ
dti-1319	357	2	advances	advance	NOUN
dti-1319	357	3	against	against	ADP
dti-1319	357	4	malaria	malaria	NOUN
dti-1319	357	5	in	in	ADP
dti-1319	357	6	2003	2003	NUM
dti-1319	357	7	.	.	PUNCT
dti-1319	358	1	med	med	PROPN
dti-1319	358	2	.	.	PUNCT
dti-1319	358	3	trop	trop	PROPN
dti-1319	358	4	.	.	PROPN
dti-1319	358	5	,	,	PUNCT
dti-1319	358	6	63:267–70	63:267–70	NOUN
dti-1319	358	7	.	.	PUNCT
dti-1319	359	1	darfeuille	darfeuille	PROPN
dti-1319	359	2	,	,	PUNCT
dti-1319	359	3	f.	f.	PROPN
dti-1319	359	4	,	,	PUNCT
dti-1319	359	5	arzumanov	arzumanov	NOUN
dti-1319	359	6	,	,	PUNCT
dti-1319	359	7	a.	a.	NOUN
dti-1319	359	8	,	,	PUNCT
dti-1319	359	9	gait	gait	PROPN
dti-1319	359	10	,	,	PUNCT
dti-1319	359	11	m.j	m.j	PROPN
dti-1319	359	12	.	.	PROPN
dti-1319	359	13	,	,	PUNCT
dti-1319	359	14	et	et	PROPN
dti-1319	359	15	al	al	PROPN
dti-1319	359	16	.	.	PROPN
dti-1319	359	17	2002a	2002a	NOUN
dti-1319	359	18	.	.	PUNCT
dti-1319	360	1	2′-o	2′-o	NUM
dti-1319	360	2	-	-	PUNCT
dti-1319	360	3	methyl	methyl	NOUN
dti-1319	360	4	-	-	PUNCT
dti-1319	360	5	rna	rna	NOUN
dti-1319	360	6	hairpins	hairpin	NOUN
dti-1319	360	7	generate	generate	VERB
dti-1319	360	8	loop	loop	NOUN
dti-1319	360	9	-	-	PUNCT
dti-1319	360	10	loop	loop	NOUN
dti-1319	360	11	complexes	complex	NOUN
dti-1319	360	12	and	and	CCONJ
dti-1319	360	13	selectively	selectively	ADV
dti-1319	360	14	inhibit	inhibit	VERB
dti-1319	360	15	hiv-1	hiv-1	PUNCT
dti-1319	360	16	tat	tat	ADJ
dti-1319	360	17	-	-	PUNCT
dti-1319	360	18	mediated	mediate	VERB
dti-1319	360	19	transcription	transcription	NOUN
dti-1319	360	20	.	.	PUNCT
dti-1319	361	1	biochemistry	biochemistry	NOUN
dti-1319	361	2	,	,	PUNCT
dti-1319	361	3	41:12186–92	41:12186–92	X
dti-1319	361	4	.	.	PUNCT
dti-1319	362	1	darfeuille	darfeuille	PROPN
dti-1319	362	2	,	,	PUNCT
dti-1319	362	3	f.	f.	PROPN
dti-1319	362	4	,	,	PUNCT
dti-1319	362	5	arzumanov	arzumanov	NOUN
dti-1319	362	6	,	,	PUNCT
dti-1319	362	7	a.	a.	NOUN
dti-1319	362	8	,	,	PUNCT
dti-1319	362	9	gryaznov	gryaznov	PROPN
dti-1319	362	10	,	,	PUNCT
dti-1319	362	11	s.	s.	PROPN
dti-1319	362	12	,	,	PUNCT
dti-1319	362	13	et	et	PROPN
dti-1319	362	14	al	al	PROPN
dti-1319	362	15	.	.	PROPN
dti-1319	362	16	2002b	2002b	NUM
dti-1319	362	17	.	.	PUNCT
dti-1319	363	1	loop	loop	NOUN
dti-1319	363	2	-	-	PUNCT
dti-1319	363	3	loop	loop	NOUN
dti-1319	363	4	interaction	interaction	NOUN
dti-1319	363	5	of	of	ADP
dti-1319	363	6	hiv-1	hiv-1	X
dti-1319	363	7	tar	tar	NOUN
dti-1319	363	8	rna	rna	NOUN
dti-1319	363	9	with	with	ADP
dti-1319	363	10	n3′-->p5′	n3′-->p5′	NOUN
dti-1319	363	11	deoxyphosphoramidate	deoxyphosphoramidate	PROPN
dti-1319	363	12	aptamers	aptamer	NOUN
dti-1319	363	13	inhibits	inhibit	VERB
dti-1319	363	14	in	in	ADP
dti-1319	363	15	vitro	vitro	X
dti-1319	363	16	tat	tat	ADJ
dti-1319	363	17	-	-	PUNCT
dti-1319	363	18	mediated	mediate	VERB
dti-1319	363	19	transcription	transcription	NOUN
dti-1319	363	20	.	.	PUNCT
dti-1319	364	1	proc	proc	PROPN
dti-1319	364	2	.	.	PUNCT
dti-1319	365	1	natl	natl	PROPN
dti-1319	365	2	.	.	PUNCT
dti-1319	366	1	acad	acad	PROPN
dti-1319	366	2	.	.	PUNCT
dti-1319	367	1	sci	sci	PROPN
dti-1319	367	2	.	.	PUNCT
dti-1319	367	3	u.s.a	u.s.a	PROPN
dti-1319	367	4	.	.	PROPN
dti-1319	367	5	,	,	PUNCT
dti-1319	367	6	99:9709–14	99:9709–14	X
dti-1319	368	1	.	.	PUNCT
dti-1319	368	2	darfeuille	darfeuille	PROPN
dti-1319	368	3	,	,	PUNCT
dti-1319	368	4	f.	f.	PROPN
dti-1319	368	5	,	,	PUNCT
dti-1319	368	6	hansen	hansen	PROPN
dti-1319	368	7	,	,	PUNCT
dti-1319	368	8	j.b	j.b	PROPN
dti-1319	368	9	.	.	PROPN
dti-1319	368	10	,	,	PUNCT
dti-1319	368	11	orum	orum	PROPN
dti-1319	368	12	,	,	PUNCT
dti-1319	368	13	h.	h.	PROPN
dti-1319	368	14	,	,	PUNCT
dti-1319	368	15	et	et	PROPN
dti-1319	368	16	al	al	PROPN
dti-1319	368	17	.	.	PROPN
dti-1319	368	18	2004	2004	NUM
dti-1319	368	19	.	.	PUNCT
dti-1319	369	1	lna	lna	PROPN
dti-1319	369	2	/	/	SYM
dti-1319	369	3	dna	dna	PROPN
dti-1319	369	4	chimeric	chimeric	ADJ
dti-1319	369	5	oligomers	oligomer	NOUN
dti-1319	369	6	mimic	mimic	VERB
dti-1319	369	7	rna	rna	NOUN
dti-1319	369	8	aptamers	aptamer	NOUN
dti-1319	369	9	targeted	target	VERB
dti-1319	369	10	to	to	ADP
dti-1319	369	11	the	the	DET
dti-1319	369	12	tar	tar	NOUN
dti-1319	369	13	rna	rna	NOUN
dti-1319	369	14	element	element	NOUN
dti-1319	369	15	of	of	ADP
dti-1319	369	16	hiv-1	hiv-1	X
dti-1319	369	17	.	.	PUNCT
dti-1319	370	1	nucleic	nucleic	ADJ
dti-1319	370	2	acids	acid	NOUN
dti-1319	370	3	res	re	NOUN
dti-1319	370	4	.	.	PUNCT
dti-1319	370	5	,	,	PUNCT
dti-1319	370	6	32:3101–7	32:3101–7	X
dti-1319	370	7	.	.	PUNCT
dti-1319	371	1	dayle	dayle	PROPN
dti-1319	371	2	,	,	PUNCT
dti-1319	371	3	h.	h.	PROPN
dti-1319	371	4	2001	2001	NUM
dti-1319	371	5	.	.	PUNCT
dti-1319	372	1	transscleral	transscleral	ADJ
dti-1319	372	2	drug	drug	NOUN
dti-1319	372	3	delivery	delivery	NOUN
dti-1319	372	4	for	for	ADP
dti-1319	372	5	posterior	posterior	ADJ
dti-1319	372	6	segment	segment	NOUN
dti-1319	372	7	disease	disease	NOUN
dti-1319	372	8	.	.	PUNCT
dti-1319	373	1	adv	adv	PROPN
dti-1319	373	2	.	.	PUNCT
dti-1319	373	3	drug	drug	PROPN
dti-1319	373	4	deliv	deliv	PROPN
dti-1319	373	5	.	.	PUNCT
dti-1319	374	1	rev	rev	PROPN
dti-1319	374	2	.	.	PROPN
dti-1319	374	3	,	,	PUNCT
dti-1319	374	4	52:37–48	52:37–48	NUM
dti-1319	374	5	.	.	PUNCT
dti-1319	375	1	ducongé	ducongé	PROPN
dti-1319	375	2	,	,	PUNCT
dti-1319	375	3	f.	f.	PROPN
dti-1319	375	4	and	and	CCONJ
dti-1319	375	5	toulmé	toulmé	ADJ
dti-1319	375	6	,	,	PUNCT
dti-1319	375	7	j.j	j.j	PROPN
dti-1319	375	8	.	.	PROPN
dti-1319	375	9	1999	1999	NUM
dti-1319	375	10	.	.	PUNCT
dti-1319	376	1	in	in	ADP
dti-1319	376	2	vitro	vitro	X
dti-1319	376	3	selection	selection	NOUN
dti-1319	376	4	identifi	identifi	NOUN
dti-1319	376	5	es	es	ADP
dti-1319	376	6	key	key	ADJ
dti-1319	376	7	determinants	determinant	NOUN
dti-1319	376	8	for	for	ADP
dti-1319	376	9	loop	loop	NOUN
dti-1319	376	10	-	-	PUNCT
dti-1319	376	11	loop	loop	NOUN
dti-1319	376	12	interactions	interaction	NOUN
dti-1319	376	13	:	:	PUNCT
dti-1319	376	14	rna	rna	NOUN
dti-1319	376	15	aptamers	aptamer	NOUN
dti-1319	376	16	selective	selective	ADJ
dti-1319	376	17	for	for	ADP
dti-1319	376	18	the	the	DET
dti-1319	376	19	tar	tar	NOUN
dti-1319	376	20	rna	rna	NOUN
dti-1319	376	21	element	element	NOUN
dti-1319	376	22	of	of	ADP
dti-1319	376	23	hiv-1	hiv-1	X
dti-1319	376	24	.	.	PUNCT
dti-1319	377	1	rna	rna	PROPN
dti-1319	377	2	,	,	PUNCT
dti-1319	377	3	5:1605–14	5:1605–14	PROPN
dti-1319	377	4	.	.	PUNCT
dti-1319	378	1	dyke	dyke	PROPN
dti-1319	378	2	,	,	PUNCT
dti-1319	378	3	c.k	c.k	PROPN
dti-1319	378	4	.	.	PROPN
dti-1319	378	5	,	,	PUNCT
dti-1319	378	6	steinhubl	steinhubl	PROPN
dti-1319	378	7	,	,	PUNCT
dti-1319	378	8	s.r	s.r	PROPN
dti-1319	378	9	.	.	PROPN
dti-1319	378	10	,	,	PUNCT
dti-1319	378	11	kleiman	kleiman	PROPN
dti-1319	378	12	,	,	PUNCT
dti-1319	378	13	n.s	n.s	PROPN
dti-1319	378	14	.	.	PROPN
dti-1319	378	15	,	,	PUNCT
dti-1319	378	16	et	et	PROPN
dti-1319	378	17	al	al	PROPN
dti-1319	378	18	.	.	PROPN
dti-1319	378	19	2006	2006	NUM
dti-1319	378	20	.	.	PUNCT
dti-1319	379	1	first	first	ADJ
dti-1319	379	2	-	-	PUNCT
dti-1319	379	3	in	in	ADP
dti-1319	379	4	-	-	PUNCT
dti-1319	379	5	human	human	ADJ
dti-1319	379	6	experience	experience	NOUN
dti-1319	379	7	of	of	ADP
dti-1319	379	8	an	an	DET
dti-1319	379	9	antidote	antidote	NOUN
dti-1319	379	10	-	-	PUNCT
dti-1319	379	11	controlled	control	VERB
dti-1319	379	12	anticoagulant	anticoagulant	NOUN
dti-1319	379	13	using	use	VERB
dti-1319	379	14	rna	rna	NOUN
dti-1319	379	15	aptamer	aptamer	NOUN
dti-1319	379	16	technology	technology	NOUN
dti-1319	379	17	:	:	PUNCT
dti-1319	379	18	a	a	DET
dti-1319	379	19	phase	phase	NOUN
dti-1319	379	20	1a	1a	VERB
dti-1319	379	21	pharmacodynamic	pharmacodynamic	ADJ
dti-1319	379	22	evaluation	evaluation	NOUN
dti-1319	379	23	of	of	ADP
dti-1319	379	24	a	a	DET
dti-1319	379	25	drug	drug	NOUN
dti-1319	379	26	-	-	PUNCT
dti-1319	379	27	antidote	antidote	NOUN
dti-1319	379	28	pair	pair	NOUN
dti-1319	379	29	for	for	ADP
dti-1319	379	30	the	the	DET
dti-1319	379	31	controlled	control	VERB
dti-1319	379	32	regulation	regulation	NOUN
dti-1319	379	33	of	of	ADP
dti-1319	379	34	factor	factor	NOUN
dti-1319	379	35	ixa	ixa	NOUN
dti-1319	379	36	activity	activity	NOUN
dti-1319	379	37	.	.	PUNCT
dti-1319	380	1	circulation	circulation	NOUN
dti-1319	380	2	,	,	PUNCT
dti-1319	380	3	114:2490–7	114:2490–7	NUM
dti-1319	380	4	.	.	PUNCT
dti-1319	381	1	eckerdt	eckerdt	PROPN
dti-1319	381	2	,	,	PUNCT
dti-1319	381	3	f.	f.	PROPN
dti-1319	381	4	,	,	PUNCT
dti-1319	381	5	yuan	yuan	PROPN
dti-1319	381	6	,	,	PUNCT
dti-1319	381	7	j.	j.	PROPN
dti-1319	381	8	and	and	CCONJ
dti-1319	381	9	strebhardt	strebhardt	PROPN
dti-1319	381	10	,	,	PUNCT
dti-1319	381	11	k.	k.	PROPN
dti-1319	381	12	2005	2005	NUM
dti-1319	381	13	.	.	PUNCT
dti-1319	382	1	polo	polo	NOUN
dti-1319	382	2	-	-	PUNCT
dti-1319	382	3	like	like	ADJ
dti-1319	382	4	kinases	kinase	NOUN
dti-1319	382	5	and	and	CCONJ
dti-1319	382	6	oncogenesis	oncogenesis	NOUN
dti-1319	382	7	.	.	PUNCT
dti-1319	383	1	oncogene	oncogene	NOUN
dti-1319	383	2	,	,	PUNCT
dti-1319	383	3	24:267–76	24:267–76	NOUN
dti-1319	383	4	.	.	PUNCT
dti-1319	384	1	elbashir	elbashir	PROPN
dti-1319	384	2	,	,	PUNCT
dti-1319	384	3	s.m	s.m	PROPN
dti-1319	384	4	.	.	PROPN
dti-1319	384	5	,	,	PUNCT
dti-1319	384	6	lendeckel	lendeckel	PROPN
dti-1319	384	7	,	,	PUNCT
dti-1319	384	8	w.	w.	PROPN
dti-1319	384	9	and	and	CCONJ
dti-1319	384	10	tuschl	tuschl	NOUN
dti-1319	384	11	,	,	PUNCT
dti-1319	384	12	t.	t.	NOUN
dti-1319	384	13	2001a	2001a	NOUN
dti-1319	384	14	.	.	PUNCT
dti-1319	385	1	rna	rna	NOUN
dti-1319	385	2	interference	interference	NOUN
dti-1319	385	3	is	be	AUX
dti-1319	385	4	mediated	mediate	VERB
dti-1319	385	5	by	by	ADP
dti-1319	385	6	21	21	NUM
dti-1319	385	7	and	and	CCONJ
dti-1319	385	8	22	22	NUM
dti-1319	385	9	nt	not	PART
dti-1319	385	10	rnas	rna	NOUN
dti-1319	385	11	.	.	PUNCT
dti-1319	386	1	genes	gene	NOUN
dti-1319	386	2	.	.	PUNCT
dti-1319	387	1	dev	dev	PROPN
dti-1319	387	2	.	.	PROPN
dti-1319	387	3	,	,	PUNCT
dti-1319	387	4	15:188−200	15:188−200	X
dti-1319	387	5	.	.	X
dti-1319	387	6	elbashir	elbashir	PROPN
dti-1319	387	7	,	,	PUNCT
dti-1319	387	8	s.m	s.m	PROPN
dti-1319	387	9	.	.	PROPN
dti-1319	387	10	,	,	PUNCT
dti-1319	387	11	martinez	martinez	PROPN
dti-1319	387	12	,	,	PUNCT
dti-1319	387	13	j.	j.	PROPN
dti-1319	387	14	,	,	PUNCT
dti-1319	387	15	patkaniowska	patkaniowska	PROPN
dti-1319	387	16	,	,	PUNCT
dti-1319	387	17	a.	a.	NOUN
dti-1319	387	18	,	,	PUNCT
dti-1319	387	19	et	et	PROPN
dti-1319	387	20	al	al	PROPN
dti-1319	387	21	.	.	PROPN
dti-1319	387	22	2001b	2001b	NUM
dti-1319	387	23	.	.	PUNCT
dti-1319	388	1	functional	functional	ADJ
dti-1319	388	2	anatomy	anatomy	NOUN
dti-1319	388	3	of	of	ADP
dti-1319	388	4	sirnas	sirna	NOUN
dti-1319	388	5	for	for	ADP
dti-1319	388	6	mediating	mediate	VERB
dti-1319	388	7	effi	effi	PROPN
dti-1319	388	8	cient	cient	PROPN
dti-1319	388	9	rnai	rnai	PROPN
dti-1319	388	10	in	in	ADP
dti-1319	388	11	drosophila	drosophila	NOUN
dti-1319	388	12	melanogaster	melanogaster	NOUN
dti-1319	388	13	embryo	embryo	NOUN
dti-1319	388	14	lysate	lysate	NOUN
dti-1319	388	15	.	.	PUNCT
dti-1319	389	1	embo	embo	PROPN
dti-1319	389	2	j	j	PROPN
dti-1319	389	3	,	,	PUNCT
dti-1319	389	4	20:6877–88	20:6877–88	NUM
dti-1319	389	5	.	.	PUNCT
dti-1319	390	1	famulok	famulok	PROPN
dti-1319	390	2	,	,	PUNCT
dti-1319	390	3	m.	m.	NOUN
dti-1319	390	4	,	,	PUNCT
dti-1319	390	5	blind	blind	ADJ
dti-1319	390	6	,	,	PUNCT
dti-1319	390	7	m.	m.	NOUN
dti-1319	390	8	and	and	CCONJ
dti-1319	390	9	mayer	mayer	PROPN
dti-1319	390	10	,	,	PUNCT
dti-1319	390	11	g.	g.	PROPN
dti-1319	390	12	2001	2001	NUM
dti-1319	390	13	.	.	PUNCT
dti-1319	391	1	intramers	intramer	NOUN
dti-1319	391	2	as	as	ADP
dti-1319	391	3	promising	promise	VERB
dti-1319	391	4	new	new	ADJ
dti-1319	391	5	tools	tool	NOUN
dti-1319	391	6	in	in	ADP
dti-1319	391	7	functional	functional	ADJ
dti-1319	391	8	proteomics	proteomic	NOUN
dti-1319	391	9	.	.	PUNCT
dti-1319	392	1	chem	chem	NOUN
dti-1319	392	2	.	.	PUNCT
dti-1319	393	1	biol	biol	PROPN
dti-1319	393	2	.	.	PUNCT
dti-1319	393	3	,	,	PUNCT
dti-1319	393	4	8	8	NUM
dti-1319	393	5	:	:	SYM
dti-1319	393	6	931–9	931–9	NOUN
dti-1319	393	7	.	.	PUNCT
dti-1319	394	1	farokhzad	farokhzad	PROPN
dti-1319	394	2	,	,	PUNCT
dti-1319	394	3	o.c	o.c	PROPN
dti-1319	394	4	.	.	PROPN
dti-1319	394	5	,	,	PUNCT
dti-1319	394	6	cheng	cheng	PROPN
dti-1319	394	7	,	,	PUNCT
dti-1319	394	8	j.	j.	PROPN
dti-1319	394	9	,	,	PUNCT
dti-1319	394	10	teply	teply	ADV
dti-1319	394	11	,	,	PUNCT
dti-1319	394	12	b.a	b.a	PROPN
dti-1319	394	13	.	.	PROPN
dti-1319	394	14	,	,	PUNCT
dti-1319	394	15	et	et	PROPN
dti-1319	394	16	al	al	PROPN
dti-1319	394	17	.	.	PROPN
dti-1319	394	18	2006	2006	NUM
dti-1319	394	19	.	.	PUNCT
dti-1319	395	1	targeted	target	VERB
dti-1319	395	2	nanoparticleaptamer	nanoparticleaptamer	NOUN
dti-1319	395	3	bioconjugates	bioconjugate	NOUN
dti-1319	395	4	for	for	ADP
dti-1319	395	5	cancer	cancer	NOUN
dti-1319	395	6	chemotherapy	chemotherapy	NOUN
dti-1319	395	7	in	in	ADP
dti-1319	395	8	vivo	vivo	NOUN
dti-1319	395	9	.	.	PUNCT
dti-1319	396	1	proc	proc	PROPN
dti-1319	396	2	.	.	PUNCT
dti-1319	397	1	natl	natl	PROPN
dti-1319	397	2	.	.	PUNCT
dti-1319	398	1	acad	acad	PROPN
dti-1319	398	2	.	.	PUNCT
dti-1319	399	1	sci	sci	PROPN
dti-1319	399	2	.	.	PUNCT
dti-1319	399	3	u.s.a	u.s.a	PROPN
dti-1319	399	4	.	.	PROPN
dti-1319	399	5	,	,	PUNCT
dti-1319	399	6	103:6315–20	103:6315–20	NUM
dti-1319	399	7	.	.	PUNCT
dti-1319	400	1	farokhzad	farokhzad	PROPN
dti-1319	400	2	,	,	PUNCT
dti-1319	400	3	o.c	o.c	PROPN
dti-1319	400	4	.	.	PROPN
dti-1319	400	5	,	,	PUNCT
dti-1319	400	6	jon	jon	PROPN
dti-1319	400	7	,	,	PUNCT
dti-1319	400	8	s.	s.	PROPN
dti-1319	400	9	,	,	PUNCT
dti-1319	400	10	khademhosseini	khademhosseini	PROPN
dti-1319	400	11	,	,	PUNCT
dti-1319	400	12	a.	a.	NOUN
dti-1319	400	13	,	,	PUNCT
dti-1319	400	14	et	et	PROPN
dti-1319	400	15	al	al	PROPN
dti-1319	400	16	.	.	PROPN
dti-1319	400	17	2004	2004	NUM
dti-1319	400	18	.	.	PUNCT
dti-1319	401	1	nanoparticleaptamer	nanoparticleaptamer	NOUN
dti-1319	401	2	bioconjugates	bioconjugate	VERB
dti-1319	401	3	:	:	PUNCT
dti-1319	401	4	a	a	DET
dti-1319	401	5	new	new	ADJ
dti-1319	401	6	approach	approach	NOUN
dti-1319	401	7	for	for	ADP
dti-1319	401	8	targeting	target	VERB
dti-1319	401	9	prostate	prostate	NOUN
dti-1319	401	10	cancer	cancer	NOUN
dti-1319	401	11	cells	cell	NOUN
dti-1319	401	12	.	.	PUNCT
dti-1319	402	1	cancer	cancer	NOUN
dti-1319	402	2	res	re	NOUN
dti-1319	402	3	.	.	PUNCT
dti-1319	402	4	,	,	PUNCT
dti-1319	402	5	64:7668–72	64:7668–72	NUM
dti-1319	402	6	.	.	PUNCT
dti-1319	402	7	fire	fire	NOUN
dti-1319	402	8	,	,	PUNCT
dti-1319	402	9	a.	a.	PROPN
dti-1319	402	10	,	,	PUNCT
dti-1319	402	11	xu	xu	PROPN
dti-1319	402	12	,	,	PUNCT
dti-1319	402	13	s.	s.	PROPN
dti-1319	402	14	,	,	PUNCT
dti-1319	402	15	montgomery	montgomery	PROPN
dti-1319	402	16	,	,	PUNCT
dti-1319	402	17	m.k	m.k	PROPN
dti-1319	402	18	.	.	PROPN
dti-1319	402	19	,	,	PUNCT
dti-1319	402	20	et	et	PROPN
dti-1319	402	21	al	al	PROPN
dti-1319	402	22	.	.	PROPN
dti-1319	402	23	1998	1998	NUM
dti-1319	402	24	.	.	PUNCT
dti-1319	403	1	potent	potent	NOUN
dti-1319	403	2	and	and	CCONJ
dti-1319	403	3	specifi	specifi	PROPN
dti-1319	403	4	c	c	PROPN
dti-1319	403	5	genetic	genetic	ADJ
dti-1319	403	6	interference	interference	NOUN
dti-1319	403	7	by	by	ADP
dti-1319	403	8	double	double	ADJ
dti-1319	403	9	-	-	PUNCT
dti-1319	403	10	stranded	strand	VERB
dti-1319	403	11	rna	rna	NOUN
dti-1319	403	12	in	in	ADP
dti-1319	403	13	caenorhabditis	caenorhabditis	PROPN
dti-1319	403	14	elegans	elegans	PROPN
dti-1319	403	15	.	.	PUNCT
dti-1319	404	1	nature	nature	NOUN
dti-1319	404	2	,	,	PUNCT
dti-1319	404	3	391:806–11	391:806–11	PROPN
dti-1319	404	4	.	.	PUNCT
dti-1319	404	5	frazza	frazza	PROPN
dti-1319	404	6	,	,	PUNCT
dti-1319	404	7	e.j	e.j	PROPN
dti-1319	404	8	.	.	PROPN
dti-1319	404	9	and	and	CCONJ
dti-1319	404	10	schmitt	schmitt	PROPN
dti-1319	404	11	,	,	PUNCT
dti-1319	404	12	e.e	e.e	PROPN
dti-1319	404	13	.	.	PROPN
dti-1319	404	14	1971	1971	NUM
dti-1319	404	15	.	.	PUNCT
dti-1319	405	1	a	a	DET
dti-1319	405	2	new	new	ADJ
dti-1319	405	3	absorbable	absorbable	ADJ
dti-1319	405	4	suture	suture	NOUN
dti-1319	405	5	.	.	PUNCT
dti-1319	406	1	j	j	PROPN
dti-1319	406	2	biomed	biome	VERB
dti-1319	406	3	.	.	PUNCT
dti-1319	407	1	mater	mater	NOUN
dti-1319	407	2	res	re	NOUN
dti-1319	407	3	.	.	PUNCT
dti-1319	407	4	symp	symp	PROPN
dti-1319	407	5	.	.	PUNCT
dti-1319	407	6	,	,	PUNCT
dti-1319	408	1	1:43–58	1:43–58	NUM
dti-1319	408	2	.	.	PUNCT
dti-1319	409	1	194	194	NUM
dti-1319	409	2	ulrich	ulrich	PROPN
dti-1319	409	3	et	et	PROPN
dti-1319	409	4	al	al	PROPN
dti-1319	409	5	drug	drug	PROPN
dti-1319	409	6	target	target	NOUN
dti-1319	409	7	insights	insight	NOUN
dti-1319	409	8	2007:2	2007:2	NUM
dti-1319	409	9	ge	ge	PROPN
dti-1319	409	10	,	,	PUNCT
dti-1319	409	11	q.	q.	PROPN
dti-1319	409	12	,	,	PUNCT
dti-1319	409	13	mcmanus	mcmanus	PROPN
dti-1319	409	14	,	,	PUNCT
dti-1319	409	15	m.t	m.t	PROPN
dti-1319	409	16	.	.	PROPN
dti-1319	409	17	,	,	PUNCT
dti-1319	409	18	nguyen	nguyen	NOUN
dti-1319	409	19	,	,	PUNCT
dti-1319	409	20	t.	t.	PROPN
dti-1319	409	21	,	,	PUNCT
dti-1319	409	22	et	et	PROPN
dti-1319	409	23	al	al	PROPN
dti-1319	409	24	.	.	PROPN
dti-1319	409	25	2003	2003	NUM
dti-1319	409	26	.	.	PUNCT
dti-1319	410	1	rna	rna	NOUN
dti-1319	410	2	interference	interference	NOUN
dti-1319	410	3	of	of	ADP
dti-1319	410	4	infl	infl	PROPN
dti-1319	410	5	uenza	uenza	PROPN
dti-1319	410	6	virus	virus	NOUN
dti-1319	410	7	production	production	NOUN
dti-1319	410	8	by	by	ADP
dti-1319	410	9	directly	directly	ADV
dti-1319	410	10	targeting	target	VERB
dti-1319	410	11	mrna	mrna	NOUN
dti-1319	410	12	for	for	ADP
dti-1319	410	13	degradation	degradation	NOUN
dti-1319	410	14	and	and	CCONJ
dti-1319	410	15	indirectly	indirectly	ADV
dti-1319	410	16	inhibiting	inhibit	VERB
dti-1319	410	17	all	all	DET
dti-1319	410	18	viral	viral	ADJ
dti-1319	410	19	rna	rna	NOUN
dti-1319	410	20	transcription	transcription	NOUN
dti-1319	410	21	.	.	PUNCT
dti-1319	411	1	proc	proc	PROPN
dti-1319	411	2	.	.	PUNCT
dti-1319	412	1	natl	natl	PROPN
dti-1319	412	2	.	.	PUNCT
dti-1319	413	1	acad	acad	PROPN
dti-1319	413	2	.	.	PUNCT
dti-1319	414	1	sci	sci	PROPN
dti-1319	414	2	.	.	PUNCT
dti-1319	414	3	u.s.a	u.s.a	PROPN
dti-1319	414	4	.	.	PROPN
dti-1319	414	5	,	,	PUNCT
dti-1319	414	6	100:2718–23	100:2718–23	PROPN
dti-1319	414	7	.	.	PUNCT
dti-1319	415	1	geisbert	geisbert	PROPN
dti-1319	415	2	,	,	PUNCT
dti-1319	415	3	t.w	t.w	PROPN
dti-1319	415	4	.	.	PROPN
dti-1319	415	5	,	,	PUNCT
dti-1319	415	6	hensley	hensley	PROPN
dti-1319	415	7	,	,	PUNCT
dti-1319	415	8	l.e	l.e	PROPN
dti-1319	415	9	.	.	PROPN
dti-1319	415	10	,	,	PUNCT
dti-1319	415	11	kagan	kagan	PROPN
dti-1319	415	12	,	,	PUNCT
dti-1319	415	13	e.	e.	PROPN
dti-1319	415	14	,	,	PUNCT
dti-1319	415	15	et	et	PROPN
dti-1319	415	16	al	al	PROPN
dti-1319	415	17	.	.	PROPN
dti-1319	415	18	2006	2006	NUM
dti-1319	415	19	.	.	PUNCT
dti-1319	416	1	postexposure	postexposure	NOUN
dti-1319	416	2	protection	protection	NOUN
dti-1319	416	3	of	of	ADP
dti-1319	416	4	guinea	guinea	NOUN
dti-1319	416	5	pigs	pig	NOUN
dti-1319	416	6	against	against	ADP
dti-1319	416	7	a	a	DET
dti-1319	416	8	lethal	lethal	ADJ
dti-1319	416	9	ebola	ebola	NOUN
dti-1319	416	10	virus	virus	NOUN
dti-1319	416	11	challenge	challenge	NOUN
dti-1319	416	12	is	be	AUX
dti-1319	416	13	conferred	confer	VERB
dti-1319	416	14	by	by	ADP
dti-1319	416	15	rna	rna	NOUN
dti-1319	416	16	interference	interference	NOUN
dti-1319	416	17	.	.	PUNCT
dti-1319	417	1	j.	j.	PROPN
dti-1319	417	2	infect	infect	PROPN
dti-1319	417	3	dis	dis	PROPN
dti-1319	417	4	.	.	PROPN
dti-1319	417	5	,	,	PUNCT
dti-1319	417	6	193:1650–7	193:1650–7	NUM
dti-1319	417	7	.	.	PUNCT
dti-1319	418	1	giordano	giordano	PROPN
dti-1319	418	2	,	,	PUNCT
dti-1319	418	3	g.g	g.g	PROPN
dti-1319	418	4	.	.	PROPN
dti-1319	418	5	,	,	PUNCT
dti-1319	418	6	chevez	chevez	NOUN
dti-1319	418	7	-	-	PUNCT
dti-1319	418	8	barrios	barrio	NOUN
dti-1319	418	9	,	,	PUNCT
dti-1319	418	10	p.	p.	NOUN
dti-1319	418	11	,	,	PUNCT
dti-1319	418	12	refojo	refojo	PROPN
dti-1319	418	13	,	,	PUNCT
dti-1319	418	14	m.f	m.f	PROPN
dti-1319	418	15	.	.	PROPN
dti-1319	418	16	,	,	PUNCT
dti-1319	418	17	et	et	PROPN
dti-1319	418	18	al	al	PROPN
dti-1319	418	19	.	.	PROPN
dti-1319	418	20	1995	1995	NUM
dti-1319	418	21	.	.	PUNCT
dti-1319	419	1	biodegradation	biodegradation	NOUN
dti-1319	419	2	and	and	CCONJ
dti-1319	419	3	tissue	tissue	NOUN
dti-1319	419	4	reaction	reaction	NOUN
dti-1319	419	5	to	to	PART
dti-1319	419	6	intravitreous	intravitreous	VERB
dti-1319	419	7	biodegradable	biodegradable	ADJ
dti-1319	419	8	poly(dl	poly(dl	NOUN
dti-1319	419	9	-	-	PUNCT
dti-1319	419	10	lactic	lactic	ADJ
dti-1319	419	11	-	-	PUNCT
dti-1319	419	12	coglycolic)acid	coglycolic)acid	NOUN
dti-1319	419	13	microspheres	microsphere	NOUN
dti-1319	419	14	.	.	PUNCT
dti-1319	420	1	curr	curr	PROPN
dti-1319	420	2	.	.	PUNCT
dti-1319	421	1	eye	eye	NOUN
dti-1319	421	2	res	re	NOUN
dti-1319	421	3	.	.	PUNCT
dti-1319	421	4	,	,	PUNCT
dti-1319	421	5	14:761–8	14:761–8	NUM
dti-1319	421	6	.	.	PUNCT
dti-1319	421	7	giraldez	giraldez	PROPN
dti-1319	421	8	,	,	PUNCT
dti-1319	421	9	a.j	a.j	PROPN
dti-1319	421	10	.	.	PROPN
dti-1319	421	11	,	,	PUNCT
dti-1319	421	12	cinalli	cinalli	PROPN
dti-1319	421	13	,	,	PUNCT
dti-1319	421	14	r.m	r.m	PROPN
dti-1319	421	15	.	.	PROPN
dti-1319	421	16	,	,	PUNCT
dti-1319	421	17	glasner	glasner	NOUN
dti-1319	421	18	,	,	PUNCT
dti-1319	421	19	m.e	m.e	PROPN
dti-1319	421	20	.	.	PROPN
dti-1319	421	21	,	,	PUNCT
dti-1319	421	22	et	et	PROPN
dti-1319	421	23	al	al	PROPN
dti-1319	421	24	.	.	PROPN
dti-1319	421	25	2005	2005	NUM
dti-1319	421	26	.	.	PUNCT
dti-1319	422	1	micrornas	microrna	NOUN
dti-1319	422	2	regulate	regulate	VERB
dti-1319	422	3	brain	brain	NOUN
dti-1319	422	4	morphogenesis	morphogenesis	NOUN
dti-1319	422	5	in	in	ADP
dti-1319	422	6	zebrafi	zebrafi	PROPN
dti-1319	422	7	sh	sh	PROPN
dti-1319	422	8	.	.	PROPN
dti-1319	422	9	science	science	PROPN
dti-1319	422	10	,	,	PUNCT
dti-1319	422	11	308:833–8	308:833–8	NUM
dti-1319	422	12	.	.	PUNCT
dti-1319	423	1	good	good	ADJ
dti-1319	423	2	,	,	PUNCT
dti-1319	423	3	p.d	p.d	PROPN
dti-1319	423	4	.	.	PROPN
dti-1319	423	5	,	,	PUNCT
dti-1319	423	6	krikos	krikos	PROPN
dti-1319	423	7	,	,	PUNCT
dti-1319	423	8	a.j	a.j	PROPN
dti-1319	423	9	.	.	PROPN
dti-1319	423	10	,	,	PUNCT
dti-1319	423	11	li	li	PROPN
dti-1319	423	12	,	,	PUNCT
dti-1319	423	13	s.x	s.x	PROPN
dti-1319	423	14	.	.	PROPN
dti-1319	423	15	,	,	PUNCT
dti-1319	423	16	et	et	PROPN
dti-1319	423	17	al	al	PROPN
dti-1319	423	18	.	.	PROPN
dti-1319	423	19	1997	1997	NUM
dti-1319	423	20	.	.	PUNCT
dti-1319	424	1	expression	expression	NOUN
dti-1319	424	2	of	of	ADP
dti-1319	424	3	small	small	ADJ
dti-1319	424	4	,	,	PUNCT
dti-1319	424	5	therapeutic	therapeutic	ADJ
dti-1319	424	6	rnas	rna	NOUN
dti-1319	424	7	in	in	ADP
dti-1319	424	8	human	human	ADJ
dti-1319	424	9	cell	cell	NOUN
dti-1319	424	10	nuclei	nucleus	NOUN
dti-1319	424	11	.	.	PUNCT
dti-1319	425	1	gene	gene	NOUN
dti-1319	425	2	.	.	PUNCT
dti-1319	426	1	ther	ther	PROPN
dti-1319	426	2	.	.	PUNCT
dti-1319	426	3	,	,	PUNCT
dti-1319	426	4	4:45–54	4:45–54	NUM
dti-1319	426	5	.	.	NOUN
dti-1319	426	6	grzelinski	grzelinski	ADJ
dti-1319	426	7	,	,	PUNCT
dti-1319	426	8	m.	m.	NOUN
dti-1319	426	9	,	,	PUNCT
dti-1319	426	10	urban	urban	ADJ
dti-1319	426	11	-	-	PUNCT
dti-1319	426	12	klein	klein	PROPN
dti-1319	426	13	,	,	PUNCT
dti-1319	426	14	b.	b.	PROPN
dti-1319	426	15	,	,	PUNCT
dti-1319	426	16	martens	martens	PROPN
dti-1319	426	17	,	,	PUNCT
dti-1319	426	18	t.	t.	PROPN
dti-1319	426	19	,	,	PUNCT
dti-1319	426	20	et	et	PROPN
dti-1319	426	21	al	al	PROPN
dti-1319	426	22	.	.	PROPN
dti-1319	426	23	2006	2006	NUM
dti-1319	426	24	.	.	PUNCT
dti-1319	427	1	rna	rna	NOUN
dti-1319	427	2	interferencemediated	interferencemediate	VERB
dti-1319	427	3	gene	gene	NOUN
dti-1319	427	4	silencing	silence	VERB
dti-1319	427	5	of	of	ADP
dti-1319	427	6	pleiotrophin	pleiotrophin	NOUN
dti-1319	427	7	through	through	ADP
dti-1319	427	8	polyethyleniminecomplexed	polyethyleniminecomplexe	VERB
dti-1319	427	9	small	small	ADJ
dti-1319	427	10	interfering	interfere	VERB
dti-1319	427	11	rnas	rna	NOUN
dti-1319	427	12	in	in	ADP
dti-1319	427	13	vivo	vivo	NOUN
dti-1319	427	14	exerts	exert	VERB
dti-1319	427	15	antitumoral	antitumoral	ADJ
dti-1319	427	16	effects	effect	NOUN
dti-1319	427	17	in	in	ADP
dti-1319	427	18	glioblastoma	glioblastoma	NOUN
dti-1319	427	19	xenografts	xenograft	NOUN
dti-1319	427	20	.	.	PUNCT
dti-1319	428	1	hum	hum	ADJ
dti-1319	428	2	.	.	PUNCT
dti-1319	429	1	gene	gene	NOUN
dti-1319	429	2	.	.	PUNCT
dti-1319	430	1	ther	ther	PROPN
dti-1319	430	2	.	.	PUNCT
dti-1319	430	3	,	,	PUNCT
dti-1319	430	4	17:751–66	17:751–66	PROPN
dti-1319	430	5	.	.	PUNCT
dti-1319	431	1	guo	guo	PROPN
dti-1319	431	2	,	,	PUNCT
dti-1319	431	3	s.	s.	PROPN
dti-1319	431	4	,	,	PUNCT
dti-1319	431	5	tschammer	tschammer	NOUN
dti-1319	431	6	,	,	PUNCT
dti-1319	431	7	n.	n.	PROPN
dti-1319	431	8	,	,	PUNCT
dti-1319	431	9	mohammed	mohammed	PROPN
dti-1319	431	10	,	,	PUNCT
dti-1319	431	11	s.	s.	PROPN
dti-1319	431	12	,	,	PUNCT
dti-1319	431	13	et	et	PROPN
dti-1319	431	14	al	al	PROPN
dti-1319	431	15	.	.	PROPN
dti-1319	431	16	2005	2005	NUM
dti-1319	431	17	.	.	PUNCT
dti-1319	432	1	specifi	specifi	PROPN
dti-1319	432	2	c	c	PROPN
dti-1319	432	3	delivery	delivery	NOUN
dti-1319	432	4	of	of	ADP
dti-1319	432	5	therapeutic	therapeutic	ADJ
dti-1319	432	6	rnas	rna	NOUN
dti-1319	432	7	to	to	ADP
dti-1319	432	8	cancer	cancer	NOUN
dti-1319	432	9	cells	cell	NOUN
dti-1319	432	10	via	via	ADP
dti-1319	432	11	the	the	DET
dti-1319	432	12	dimerization	dimerization	NOUN
dti-1319	432	13	mechanism	mechanism	NOUN
dti-1319	432	14	of	of	ADP
dti-1319	432	15	phi29	phi29	ADJ
dti-1319	432	16	motor	motor	PROPN
dti-1319	432	17	prna	prna	PROPN
dti-1319	432	18	.	.	PUNCT
dti-1319	433	1	hum	hum	PROPN
dti-1319	433	2	.	.	PUNCT
dti-1319	434	1	gene	gene	NOUN
dti-1319	434	2	.	.	PUNCT
dti-1319	435	1	ther	ther	PROPN
dti-1319	435	2	.	.	PUNCT
dti-1319	435	3	,	,	PUNCT
dti-1319	436	1	16:1097–109	16:1097–109	NUM
dti-1319	436	2	.	.	PUNCT
dti-1319	437	1	hamilton	hamilton	PROPN
dti-1319	437	2	,	,	PUNCT
dti-1319	437	3	a.j	a.j	PROPN
dti-1319	437	4	.	.	PROPN
dti-1319	437	5	and	and	CCONJ
dti-1319	437	6	baulcombe	baulcombe	PROPN
dti-1319	437	7	,	,	PUNCT
dti-1319	437	8	d.c	d.c	PROPN
dti-1319	437	9	.	.	PROPN
dti-1319	437	10	1999	1999	NUM
dti-1319	437	11	.	.	PUNCT
dti-1319	438	1	a	a	DET
dti-1319	438	2	species	species	NOUN
dti-1319	438	3	of	of	ADP
dti-1319	438	4	small	small	ADJ
dti-1319	438	5	antisense	antisense	NOUN
dti-1319	438	6	rna	rna	NOUN
dti-1319	438	7	in	in	ADP
dti-1319	438	8	posttranscriptional	posttranscriptional	ADJ
dti-1319	438	9	gene	gene	NOUN
dti-1319	438	10	silencing	silence	VERB
dti-1319	438	11	in	in	ADP
dti-1319	438	12	plants	plant	NOUN
dti-1319	438	13	.	.	PUNCT
dti-1319	439	1	science	science	NOUN
dti-1319	439	2	,	,	PUNCT
dti-1319	439	3	286:950–2	286:950–2	NUM
dti-1319	439	4	.	.	PUNCT
dti-1319	440	1	hammond	hammond	PROPN
dti-1319	440	2	,	,	PUNCT
dti-1319	440	3	s.m	s.m	PROPN
dti-1319	440	4	.	.	PROPN
dti-1319	440	5	,	,	PUNCT
dti-1319	440	6	bernstein	bernstein	PROPN
dti-1319	440	7	,	,	PUNCT
dti-1319	440	8	e.	e.	PROPN
dti-1319	440	9	,	,	PUNCT
dti-1319	440	10	beach	beach	PROPN
dti-1319	440	11	,	,	PUNCT
dti-1319	440	12	d.	d.	PROPN
dti-1319	440	13	,	,	PUNCT
dti-1319	440	14	et	et	PROPN
dti-1319	440	15	al	al	PROPN
dti-1319	440	16	.	.	PROPN
dti-1319	440	17	2000	2000	NUM
dti-1319	440	18	.	.	PUNCT
dti-1319	441	1	an	an	DET
dti-1319	441	2	rna	rna	NOUN
dti-1319	441	3	-	-	PUNCT
dti-1319	441	4	directed	direct	VERB
dti-1319	441	5	nuclease	nuclease	NOUN
dti-1319	441	6	mediates	mediate	NOUN
dti-1319	441	7	post	post	ADJ
dti-1319	441	8	-	-	ADJ
dti-1319	441	9	transcriptional	transcriptional	ADJ
dti-1319	441	10	gene	gene	NOUN
dti-1319	441	11	silencing	silence	VERB
dti-1319	441	12	in	in	ADP
dti-1319	441	13	drosophila	drosophila	NOUN
dti-1319	441	14	cells	cell	NOUN
dti-1319	441	15	.	.	PUNCT
dti-1319	442	1	nature	nature	NOUN
dti-1319	442	2	,	,	PUNCT
dti-1319	442	3	404:293–6	404:293–6	NUM
dti-1319	442	4	.	.	PUNCT
dti-1319	443	1	harper	harper	PROPN
dti-1319	443	2	,	,	PUNCT
dti-1319	443	3	s.q	s.q	PROPN
dti-1319	443	4	.	.	PROPN
dti-1319	443	5	,	,	PUNCT
dti-1319	443	6	staber	staber	PROPN
dti-1319	443	7	,	,	PUNCT
dti-1319	443	8	p.d	p.d	PROPN
dti-1319	443	9	.	.	PROPN
dti-1319	443	10	,	,	PUNCT
dti-1319	443	11	he	he	PRON
dti-1319	443	12	,	,	PUNCT
dti-1319	443	13	x.	x.	PROPN
dti-1319	443	14	,	,	PUNCT
dti-1319	443	15	et	et	PROPN
dti-1319	443	16	al	al	PROPN
dti-1319	443	17	.	.	PROPN
dti-1319	443	18	2005	2005	NUM
dti-1319	443	19	.	.	PUNCT
dti-1319	444	1	rna	rna	NOUN
dti-1319	444	2	interference	interference	NOUN
dti-1319	444	3	improves	improve	VERB
dti-1319	444	4	motor	motor	NOUN
dti-1319	444	5	and	and	CCONJ
dti-1319	444	6	neuropathological	neuropathological	ADJ
dti-1319	444	7	abnormalities	abnormality	NOUN
dti-1319	444	8	in	in	ADP
dti-1319	444	9	a	a	DET
dti-1319	444	10	huntington	huntington	PROPN
dti-1319	444	11	’s	’s	PART
dti-1319	444	12	disease	disease	PROPN
dti-1319	444	13	mouse	mouse	PROPN
dti-1319	444	14	model	model	NOUN
dti-1319	444	15	.	.	PUNCT
dti-1319	445	1	proc	proc	NOUN
dti-1319	445	2	.	.	PUNCT
dti-1319	446	1	nat.l	nat.l	PROPN
dti-1319	446	2	acad	acad	PROPN
dti-1319	446	3	.	.	PUNCT
dti-1319	447	1	sci	sci	PROPN
dti-1319	447	2	.	.	PUNCT
dti-1319	447	3	u.s.a	u.s.a	PROPN
dti-1319	447	4	.	.	PROPN
dti-1319	447	5	,	,	PUNCT
dti-1319	447	6	102:5820–5	102:5820–5	X
dti-1319	447	7	.	.	PUNCT
dti-1319	448	1	hasirci	hasirci	PROPN
dti-1319	448	2	,	,	PUNCT
dti-1319	448	3	v.	v.	PROPN
dti-1319	448	4	,	,	PUNCT
dti-1319	448	5	berthiaume	berthiaume	PROPN
dti-1319	448	6	,	,	PUNCT
dti-1319	448	7	f.	f.	PROPN
dti-1319	448	8	,	,	PUNCT
dti-1319	448	9	bondre	bondre	PROPN
dti-1319	448	10	,	,	PUNCT
dti-1319	448	11	s.p	s.p	PROPN
dti-1319	448	12	.	.	PROPN
dti-1319	448	13	,	,	PUNCT
dti-1319	448	14	et	et	PROPN
dti-1319	448	15	al	al	PROPN
dti-1319	448	16	.	.	PROPN
dti-1319	448	17	2001	2001	NUM
dti-1319	448	18	.	.	PUNCT
dti-1319	449	1	expression	expression	NOUN
dti-1319	449	2	of	of	ADP
dti-1319	449	3	liverspecifi	liverspecifi	NOUN
dti-1319	449	4	c	c	NOUN
dti-1319	449	5	functions	function	NOUN
dti-1319	449	6	by	by	ADP
dti-1319	449	7	rat	rat	NOUN
dti-1319	449	8	hepatocytes	hepatocyte	NOUN
dti-1319	449	9	seeded	seed	VERB
dti-1319	449	10	in	in	ADP
dti-1319	449	11	treated	treat	VERB
dti-1319	449	12	poly(lactic	poly(lactic	ADJ
dti-1319	449	13	-	-	PUNCT
dti-1319	449	14	coglycolic	coglycolic	NOUN
dti-1319	449	15	)	)	PUNCT
dti-1319	449	16	acid	acid	ADJ
dti-1319	449	17	biodegradable	biodegradable	ADJ
dti-1319	449	18	foams	foam	NOUN
dti-1319	449	19	.	.	PUNCT
dti-1319	450	1	tissue	tissue	NOUN
dti-1319	450	2	eng	eng	PROPN
dti-1319	450	3	.	.	PROPN
dti-1319	450	4	,	,	PUNCT
dti-1319	451	1	7:385–94	7:385–94	PROPN
dti-1319	451	2	.	.	PUNCT
dti-1319	451	3	herrmann	herrmann	PROPN
dti-1319	451	4	,	,	PUNCT
dti-1319	451	5	c.h	c.h	PROPN
dti-1319	451	6	.	.	PROPN
dti-1319	451	7	and	and	CCONJ
dti-1319	451	8	mancini	mancini	PROPN
dti-1319	451	9	,	,	PUNCT
dti-1319	451	10	m.a	m.a	PROPN
dti-1319	451	11	.	.	PROPN
dti-1319	451	12	2001	2001	NUM
dti-1319	451	13	.	.	PUNCT
dti-1319	452	1	the	the	DET
dti-1319	452	2	cdk9	cdk9	PROPN
dti-1319	452	3	and	and	CCONJ
dti-1319	452	4	cyclin	cyclin	PROPN
dti-1319	452	5	t	t	PROPN
dti-1319	452	6	subunits	subunit	NOUN
dti-1319	452	7	of	of	ADP
dti-1319	452	8	tak	tak	NOUN
dti-1319	452	9	/	/	SYM
dti-1319	452	10	p	p	NOUN
dti-1319	452	11	-	-	PUNCT
dti-1319	452	12	tefb	tefb	NOUN
dti-1319	452	13	localize	localize	NOUN
dti-1319	452	14	to	to	ADP
dti-1319	452	15	splicing	splicing	NOUN
dti-1319	452	16	factor	factor	NOUN
dti-1319	452	17	-	-	PUNCT
dti-1319	452	18	rich	rich	ADJ
dti-1319	452	19	nuclear	nuclear	ADJ
dti-1319	452	20	speckle	speckle	NOUN
dti-1319	452	21	regions	region	NOUN
dti-1319	452	22	.	.	PUNCT
dti-1319	453	1	j.	j.	PROPN
dti-1319	453	2	cell	cell	PROPN
dti-1319	453	3	sci	sci	PROPN
dti-1319	453	4	.	.	PROPN
dti-1319	453	5	,	,	PUNCT
dti-1319	454	1	114:1491–503	114:1491–503	NUM
dti-1319	454	2	.	.	PUNCT
dti-1319	455	1	hess	hess	PROPN
dti-1319	455	2	,	,	PUNCT
dti-1319	455	3	g.p	g.p	PROPN
dti-1319	455	4	.	.	PROPN
dti-1319	455	5	,	,	PUNCT
dti-1319	455	6	ulrich	ulrich	PROPN
dti-1319	455	7	,	,	PUNCT
dti-1319	455	8	h.	h.	PROPN
dti-1319	455	9	,	,	PUNCT
dti-1319	455	10	breitinger	breitinger	PROPN
dti-1319	455	11	,	,	PUNCT
dti-1319	455	12	h.g	h.g	PROPN
dti-1319	455	13	.	.	PROPN
dti-1319	455	14	,	,	PUNCT
dti-1319	455	15	et	et	PROPN
dti-1319	455	16	al	al	PROPN
dti-1319	455	17	.	.	PROPN
dti-1319	455	18	2000	2000	NUM
dti-1319	455	19	.	.	PUNCT
dti-1319	456	1	mechanism	mechanism	NOUN
dti-1319	456	2	-	-	PUNCT
dti-1319	456	3	based	base	VERB
dti-1319	456	4	discovery	discovery	NOUN
dti-1319	456	5	of	of	ADP
dti-1319	456	6	ligands	ligand	NOUN
dti-1319	456	7	that	that	PRON
dti-1319	456	8	counteract	counteract	VERB
dti-1319	456	9	inhibition	inhibition	NOUN
dti-1319	456	10	of	of	ADP
dti-1319	456	11	the	the	DET
dti-1319	456	12	nicotinic	nicotinic	ADJ
dti-1319	456	13	acetylcholine	acetylcholine	NOUN
dti-1319	456	14	receptor	receptor	NOUN
dti-1319	456	15	by	by	ADP
dti-1319	456	16	cocaine	cocaine	NOUN
dti-1319	456	17	and	and	CCONJ
dti-1319	456	18	mk-801	mk-801	PROPN
dti-1319	456	19	.	.	PUNCT
dti-1319	456	20	proc	proc	PROPN
dti-1319	456	21	.	.	PUNCT
dti-1319	457	1	natl	natl	PROPN
dti-1319	457	2	.	.	PUNCT
dti-1319	458	1	acad	acad	PROPN
dti-1319	458	2	.	.	PUNCT
dti-1319	459	1	sci	sci	PROPN
dti-1319	459	2	.	.	PUNCT
dti-1319	459	3	u.s.a	u.s.a	PROPN
dti-1319	459	4	.	.	PROPN
dti-1319	459	5	,	,	PUNCT
dti-1319	459	6	97:13895–900	97:13895–900	PROPN
dti-1319	459	7	.	.	PUNCT
dti-1319	459	8	hoshika	hoshika	PROPN
dti-1319	459	9	,	,	PUNCT
dti-1319	459	10	s.	s.	PROPN
dti-1319	459	11	,	,	PUNCT
dti-1319	459	12	minakawa	minakawa	PROPN
dti-1319	459	13	,	,	PUNCT
dti-1319	459	14	n.	n.	PROPN
dti-1319	459	15	and	and	CCONJ
dti-1319	459	16	matsuda	matsuda	PROPN
dti-1319	459	17	,	,	PUNCT
dti-1319	459	18	a.	a.	NOUN
dti-1319	459	19	2004	2004	NUM
dti-1319	459	20	.	.	PUNCT
dti-1319	460	1	synthesis	synthesis	NOUN
dti-1319	460	2	and	and	CCONJ
dti-1319	460	3	physical	physical	ADJ
dti-1319	460	4	and	and	CCONJ
dti-1319	460	5	physiologicalproperties	physiologicalpropertie	NOUN
dti-1319	460	6	of	of	ADP
dti-1319	460	7	4’-thiorna	4’-thiorna	NUM
dti-1319	460	8	:	:	PUNCT
dti-1319	460	9	application	application	NOUN
dti-1319	460	10	to	to	ADP
dti-1319	460	11	postmodifi	postmodifi	NOUN
dti-1319	460	12	cation	cation	NOUN
dti-1319	460	13	of	of	ADP
dti-1319	460	14	rna	rna	NOUN
dti-1319	460	15	aptamer	aptamer	NOUN
dti-1319	460	16	toward	toward	ADP
dti-1319	460	17	nf	nf	NOUN
dti-1319	460	18	-	-	PUNCT
dti-1319	460	19	κb	κb	NOUN
dti-1319	460	20	.	.	PUNCT
dti-1319	461	1	nucleic	nucleic	ADJ
dti-1319	461	2	.	.	PUNCT
dti-1319	462	1	acids	acid	NOUN
dti-1319	462	2	.	.	PUNCT
dti-1319	463	1	res	re	NOUN
dti-1319	463	2	.	.	PROPN
dti-1319	463	3	,	,	PUNCT
dti-1319	463	4	32:3815–3825	32:3815–3825	PROPN
dti-1319	463	5	.	.	PUNCT
dti-1319	463	6	hutvágner	hutvágner	PROPN
dti-1319	463	7	,	,	PUNCT
dti-1319	463	8	g.	g.	PROPN
dti-1319	463	9	and	and	CCONJ
dti-1319	463	10	zamore	zamore	PROPN
dti-1319	463	11	,	,	PUNCT
dti-1319	463	12	p.d	p.d	PROPN
dti-1319	463	13	.	.	PROPN
dti-1319	463	14	2002	2002	NUM
dti-1319	463	15	.	.	PUNCT
dti-1319	464	1	a	a	DET
dti-1319	464	2	microrna	microrna	PROPN
dti-1319	464	3	in	in	ADP
dti-1319	464	4	a	a	DET
dti-1319	464	5	multiple	multiple	ADJ
dti-1319	464	6	-	-	PUNCT
dti-1319	464	7	turnover	turnover	NOUN
dti-1319	464	8	rnai	rnai	NOUN
dti-1319	464	9	enzyme	enzyme	NOUN
dti-1319	464	10	complex	complex	NOUN
dti-1319	464	11	.	.	PUNCT
dti-1319	465	1	science	science	NOUN
dti-1319	465	2	,	,	PUNCT
dti-1319	465	3	297:2056−60	297:2056−60	NUM
dti-1319	465	4	.	.	PUNCT
dti-1319	465	5	hutvágner	hutvágner	PROPN
dti-1319	465	6	,	,	PUNCT
dti-1319	465	7	g.	g.	PROPN
dti-1319	465	8	and	and	CCONJ
dti-1319	465	9	zamore	zamore	PROPN
dti-1319	465	10	,	,	PUNCT
dti-1319	465	11	p.d	p.d	PROPN
dti-1319	465	12	.	.	PROPN
dti-1319	465	13	2005	2005	NUM
dti-1319	465	14	.	.	PUNCT
dti-1319	466	1	rnai	rnai	PROPN
dti-1319	466	2	:	:	PUNCT
dti-1319	466	3	nature	nature	NOUN
dti-1319	466	4	abhors	abhor	VERB
dti-1319	466	5	a	a	DET
dti-1319	466	6	double	double	ADJ
dti-1319	466	7	-	-	PUNCT
dti-1319	466	8	strand	strand	NOUN
dti-1319	466	9	.	.	PUNCT
dti-1319	467	1	curr	curr	PROPN
dti-1319	467	2	.	.	PUNCT
dti-1319	468	1	opin	opin	NOUN
dti-1319	468	2	.	.	PUNCT
dti-1319	469	1	genet	genet	NOUN
dti-1319	469	2	.	.	PUNCT
dti-1319	470	1	dev	dev	PROPN
dti-1319	470	2	.	.	PROPN
dti-1319	470	3	,	,	PUNCT
dti-1319	470	4	12:225–32	12:225–32	PROPN
dti-1319	470	5	.	.	PUNCT
dti-1319	471	1	jenison	jenison	PROPN
dti-1319	471	2	,	,	PUNCT
dti-1319	471	3	r.d	r.d	PROPN
dti-1319	471	4	.	.	PROPN
dti-1319	471	5	,	,	PUNCT
dti-1319	471	6	gill	gill	PROPN
dti-1319	471	7	,	,	PUNCT
dti-1319	471	8	s.c	s.c	PROPN
dti-1319	471	9	.	.	PROPN
dti-1319	471	10	,	,	PUNCT
dti-1319	471	11	pardi	pardi	PROPN
dti-1319	471	12	,	,	PUNCT
dti-1319	471	13	a.	a.	PROPN
dti-1319	471	14	,	,	PUNCT
dti-1319	471	15	et	et	PROPN
dti-1319	471	16	al	al	PROPN
dti-1319	471	17	.	.	PROPN
dti-1319	471	18	1994	1994	NUM
dti-1319	471	19	.	.	PUNCT
dti-1319	472	1	high	high	ADJ
dti-1319	472	2	-	-	PUNCT
dti-1319	472	3	resolution	resolution	NOUN
dti-1319	472	4	molecular	molecular	ADJ
dti-1319	472	5	discrimination	discrimination	NOUN
dti-1319	472	6	by	by	ADP
dti-1319	472	7	rna	rna	PROPN
dti-1319	472	8	.	.	PUNCT
dti-1319	473	1	science	science	NOUN
dti-1319	473	2	,	,	PUNCT
dti-1319	473	3	263:1425–9	263:1425–9	NUM
dti-1319	473	4	.	.	PUNCT
dti-1319	474	1	judge	judge	PROPN
dti-1319	474	2	,	,	PUNCT
dti-1319	474	3	a.d	a.d	PROPN
dti-1319	474	4	.	.	PROPN
dti-1319	474	5	,	,	PUNCT
dti-1319	474	6	sood	sood	PROPN
dti-1319	474	7	,	,	PUNCT
dti-1319	474	8	v.	v.	PROPN
dti-1319	474	9	,	,	PUNCT
dti-1319	474	10	shaw	shaw	PROPN
dti-1319	474	11	,	,	PUNCT
dti-1319	474	12	j.r	j.r	PROPN
dti-1319	474	13	.	.	PROPN
dti-1319	474	14	,	,	PUNCT
dti-1319	474	15	et	et	PROPN
dti-1319	474	16	al	al	PROPN
dti-1319	474	17	.	.	PROPN
dti-1319	474	18	2005	2005	NUM
dti-1319	474	19	.	.	PUNCT
dti-1319	475	1	sequence	sequence	NOUN
dti-1319	475	2	-	-	PUNCT
dti-1319	475	3	dependent	dependent	ADJ
dti-1319	475	4	stimulation	stimulation	NOUN
dti-1319	475	5	of	of	ADP
dti-1319	475	6	the	the	DET
dti-1319	475	7	mammalian	mammalian	ADJ
dti-1319	475	8	innate	innate	ADJ
dti-1319	475	9	immune	immune	ADJ
dti-1319	475	10	response	response	NOUN
dti-1319	475	11	by	by	ADP
dti-1319	475	12	synthetic	synthetic	ADJ
dti-1319	475	13	sirna	sirna	PROPN
dti-1319	475	14	.	.	PUNCT
dti-1319	476	1	nat	nat	PROPN
dti-1319	476	2	.	.	PUNCT
dti-1319	477	1	biotechnol	biotechnol	PROPN
dti-1319	477	2	.	.	PUNCT
dti-1319	477	3	,	,	PUNCT
dti-1319	477	4	23:457–62	23:457–62	PROPN
dti-1319	477	5	.	.	PUNCT
dti-1319	478	1	kamei	kamei	PROPN
dti-1319	478	2	,	,	PUNCT
dti-1319	478	3	m.	m.	NOUN
dti-1319	478	4	,	,	PUNCT
dti-1319	478	5	misono	misono	PROPN
dti-1319	478	6	,	,	PUNCT
dti-1319	478	7	k.	k.	PROPN
dti-1319	478	8	and	and	CCONJ
dti-1319	478	9	lewis	lewis	PROPN
dti-1319	478	10	,	,	PUNCT
dti-1319	478	11	h.	h.	PROPN
dti-1319	478	12	1999	1999	NUM
dti-1319	478	13	.	.	PUNCT
dti-1319	479	1	a	a	DET
dti-1319	479	2	study	study	NOUN
dti-1319	479	3	of	of	ADP
dti-1319	479	4	the	the	DET
dti-1319	479	5	ability	ability	NOUN
dti-1319	479	6	of	of	ADP
dti-1319	479	7	tissue	tissue	NOUN
dti-1319	479	8	plasminogen	plasminogen	NOUN
dti-1319	479	9	activator	activator	NOUN
dti-1319	479	10	to	to	PART
dti-1319	479	11	diffuse	diffuse	VERB
dti-1319	479	12	into	into	ADP
dti-1319	479	13	the	the	DET
dti-1319	479	14	subretinal	subretinal	ADJ
dti-1319	479	15	space	space	NOUN
dti-1319	479	16	after	after	ADP
dti-1319	479	17	intravitreal	intravitreal	ADJ
dti-1319	479	18	injection	injection	NOUN
dti-1319	479	19	in	in	ADP
dti-1319	479	20	rabbits	rabbit	NOUN
dti-1319	479	21	.	.	PUNCT
dti-1319	480	1	am	be	AUX
dti-1319	480	2	.	.	PUNCT
dti-1319	481	1	j.	j.	PROPN
dti-1319	481	2	ophthalmol	ophthalmol	PROPN
dti-1319	481	3	.	.	PROPN
dti-1319	481	4	,	,	PUNCT
dti-1319	481	5	128:739–46	128:739–46	NUM
dti-1319	481	6	.	.	PUNCT
dti-1319	482	1	khaled	khaled	PROPN
dti-1319	482	2	,	,	PUNCT
dti-1319	482	3	a.	a.	PROPN
dti-1319	482	4	,	,	PUNCT
dti-1319	482	5	guo	guo	PROPN
dti-1319	482	6	,	,	PUNCT
dti-1319	482	7	s.	s.	PROPN
dti-1319	482	8	,	,	PUNCT
dti-1319	482	9	li	li	PROPN
dti-1319	482	10	,	,	PUNCT
dti-1319	482	11	f.	f.	PROPN
dti-1319	482	12	and	and	CCONJ
dti-1319	482	13	guo	guo	PROPN
dti-1319	482	14	,	,	PUNCT
dti-1319	482	15	p.	p.	NOUN
dti-1319	482	16	2005	2005	NUM
dti-1319	482	17	.	.	PUNCT
dti-1319	483	1	controllable	controllable	ADJ
dti-1319	483	2	self	self	NOUN
dti-1319	483	3	-	-	PUNCT
dti-1319	483	4	assembly	assembly	NOUN
dti-1319	483	5	of	of	ADP
dti-1319	483	6	nanoparticles	nanoparticle	NOUN
dti-1319	483	7	for	for	ADP
dti-1319	483	8	specifi	specifi	PROPN
dti-1319	483	9	c	c	PROPN
dti-1319	483	10	delivery	delivery	NOUN
dti-1319	483	11	of	of	ADP
dti-1319	483	12	multiple	multiple	ADJ
dti-1319	483	13	therapeutic	therapeutic	ADJ
dti-1319	483	14	molecules	molecule	NOUN
dti-1319	483	15	to	to	ADP
dti-1319	483	16	cancer	cancer	NOUN
dti-1319	483	17	cells	cell	NOUN
dti-1319	483	18	using	use	VERB
dti-1319	483	19	rna	rna	NOUN
dti-1319	483	20	nanotechnology	nanotechnology	NOUN
dti-1319	483	21	.	.	PUNCT
dti-1319	484	1	nano	nano	PROPN
dti-1319	484	2	.	.	PUNCT
dti-1319	485	1	lett	lett	PROPN
dti-1319	485	2	.	.	PROPN
dti-1319	485	3	,	,	PUNCT
dti-1319	485	4	5:1797–808	5:1797–808	PROPN
dti-1319	485	5	.	.	PUNCT
dti-1319	486	1	kim	kim	PROPN
dti-1319	486	2	,	,	PUNCT
dti-1319	486	3	w.j	w.j	PROPN
dti-1319	486	4	.	.	PROPN
dti-1319	486	5	,	,	PUNCT
dti-1319	486	6	christensen	christensen	PROPN
dti-1319	486	7	,	,	PUNCT
dti-1319	486	8	l.v	l.v	PROPN
dti-1319	486	9	.	.	PROPN
dti-1319	486	10	,	,	PUNCT
dti-1319	486	11	jo	jo	PROPN
dti-1319	486	12	,	,	PUNCT
dti-1319	486	13	s.	s.	PROPN
dti-1319	486	14	,	,	PUNCT
dti-1319	486	15	et	et	PROPN
dti-1319	486	16	al	al	PROPN
dti-1319	486	17	.	.	PROPN
dti-1319	486	18	2006	2006	NUM
dti-1319	486	19	.	.	PUNCT
dti-1319	487	1	cholesteryl	cholesteryl	PROPN
dti-1319	487	2	oligoarginine	oligoarginine	ADJ
dti-1319	487	3	delivering	deliver	VERB
dti-1319	487	4	vascular	vascular	ADJ
dti-1319	487	5	endothelial	endothelial	ADJ
dti-1319	487	6	growth	growth	NOUN
dti-1319	487	7	factor	factor	NOUN
dti-1319	487	8	sirna	sirna	PROPN
dti-1319	487	9	effectively	effectively	ADV
dti-1319	487	10	inhibits	inhibit	VERB
dti-1319	487	11	tumor	tumor	NOUN
dti-1319	487	12	growth	growth	NOUN
dti-1319	487	13	in	in	ADP
dti-1319	487	14	colon	colon	NOUN
dti-1319	487	15	adenocarcinoma	adenocarcinoma	NOUN
dti-1319	487	16	.	.	PUNCT
dti-1319	488	1	mol	mol	PROPN
dti-1319	488	2	.	.	PROPN
dti-1319	489	1	ther	ther	PROPN
dti-1319	489	2	.	.	PUNCT
dti-1319	489	3	,	,	PUNCT
dti-1319	489	4	14:343–50	14:343–50	NUM
dti-1319	489	5	.	.	PUNCT
dti-1319	490	1	kolb	kolb	PROPN
dti-1319	490	2	,	,	PUNCT
dti-1319	490	3	g.	g.	PROPN
dti-1319	490	4	,	,	PUNCT
dti-1319	490	5	reigadas	reigada	NOUN
dti-1319	490	6	,	,	PUNCT
dti-1319	490	7	s.	s.	PROPN
dti-1319	490	8	,	,	PUNCT
dti-1319	490	9	boiziau	boiziau	PROPN
dti-1319	490	10	,	,	PUNCT
dti-1319	490	11	c.	c.	PROPN
dti-1319	490	12	,	,	PUNCT
dti-1319	490	13	et	et	PROPN
dti-1319	490	14	al	al	PROPN
dti-1319	490	15	.	.	PROPN
dti-1319	490	16	2005	2005	NUM
dti-1319	490	17	.	.	PUNCT
dti-1319	491	1	hexitol	hexitol	ADJ
dti-1319	491	2	nucleic	nucleic	ADJ
dti-1319	491	3	acidcontaining	acidcontaine	VERB
dti-1319	491	4	aptamers	aptamer	NOUN
dti-1319	491	5	are	be	AUX
dti-1319	491	6	effi	effi	PROPN
dti-1319	491	7	cient	cient	NOUN
dti-1319	491	8	ligands	ligand	NOUN
dti-1319	491	9	of	of	ADP
dti-1319	491	10	hiv-1	hiv-1	X
dti-1319	491	11	tar	tar	NOUN
dti-1319	491	12	rna	rna	NOUN
dti-1319	491	13	.	.	PUNCT
dti-1319	492	1	biochemistry	biochemistry	NOUN
dti-1319	492	2	,	,	PUNCT
dti-1319	492	3	44:2926–33	44:2926–33	NOUN
dti-1319	492	4	.	.	PUNCT
dti-1319	493	1	konopka	konopka	PROPN
dti-1319	493	2	,	,	PUNCT
dti-1319	493	3	k.	k.	PROPN
dti-1319	493	4	,	,	PUNCT
dti-1319	493	5	duzgunes	duzgune	NOUN
dti-1319	493	6	,	,	PUNCT
dti-1319	493	7	n.	n.	NOUN
dti-1319	493	8	,	,	PUNCT
dti-1319	493	9	rossi	rossi	PROPN
dti-1319	493	10	,	,	PUNCT
dti-1319	493	11	j.	j.	PROPN
dti-1319	493	12	,	,	PUNCT
dti-1319	493	13	et	et	PROPN
dti-1319	493	14	al	al	PROPN
dti-1319	493	15	.	.	PROPN
dti-1319	493	16	1998	1998	NUM
dti-1319	493	17	.	.	PUNCT
dti-1319	494	1	receptor	receptor	NOUN
dti-1319	494	2	ligand	ligand	NOUN
dti-1319	494	3	-	-	PUNCT
dti-1319	494	4	facilitated	facilitate	VERB
dti-1319	494	5	cationic	cationic	ADJ
dti-1319	494	6	liposome	liposome	NOUN
dti-1319	494	7	delivery	delivery	NOUN
dti-1319	494	8	of	of	ADP
dti-1319	494	9	anti	anti	ADJ
dti-1319	494	10	-	-	ADJ
dti-1319	494	11	hiv-1	hiv-1	X
dti-1319	494	12	rev	rev	ADJ
dti-1319	494	13	-	-	ADJ
dti-1319	494	14	binding	binding	ADJ
dti-1319	494	15	aptamer	aptamer	NOUN
dti-1319	494	16	and	and	CCONJ
dti-1319	494	17	ribozyme	ribozyme	PROPN
dti-1319	494	18	dnas	dna	NOUN
dti-1319	494	19	.	.	PUNCT
dti-1319	495	1	j.	j.	PROPN
dti-1319	495	2	drug	drug	PROPN
dti-1319	495	3	target	target	PROPN
dti-1319	495	4	,	,	PUNCT
dti-1319	495	5	5:247–59	5:247–59	PROPN
dti-1319	495	6	.	.	PUNCT
dti-1319	496	1	lam	lam	PROPN
dti-1319	496	2	,	,	PUNCT
dti-1319	496	3	t.t	t.t	PROPN
dti-1319	496	4	.	.	PROPN
dti-1319	496	5	,	,	PUNCT
dti-1319	496	6	fu	fu	PROPN
dti-1319	496	7	,	,	PUNCT
dti-1319	496	8	j.	j.	PROPN
dti-1319	496	9	,	,	PUNCT
dti-1319	496	10	tso	tso	PROPN
dti-1319	496	11	,	,	PUNCT
dti-1319	496	12	m.o	m.o	PROPN
dti-1319	496	13	.	.	PROPN
dti-1319	496	14	,	,	PUNCT
dti-1319	496	15	et	et	PROPN
dti-1319	496	16	al	al	PROPN
dti-1319	496	17	.	.	PROPN
dti-1319	496	18	1991	1991	NUM
dti-1319	496	19	.	.	PUNCT
dti-1319	497	1	a	a	DET
dti-1319	497	2	histopathologic	histopathologic	ADJ
dti-1319	497	3	study	study	NOUN
dti-1319	497	4	of	of	ADP
dti-1319	497	5	retinal	retinal	ADJ
dti-1319	497	6	lesions	lesion	NOUN
dti-1319	497	7	infl	infl	PROPN
dti-1319	497	8	icted	icte	VERB
dti-1319	497	9	by	by	ADP
dti-1319	497	10	transscleral	transscleral	ADJ
dti-1319	497	11	iontophoresis	iontophoresis	NOUN
dti-1319	497	12	.	.	PUNCT
dti-1319	498	1	graefes	graefe	NOUN
dti-1319	498	2	arch	arch	NOUN
dti-1319	498	3	.	.	PUNCT
dti-1319	499	1	clin	clin	PROPN
dti-1319	499	2	.	.	PUNCT
dti-1319	500	1	exp	exp	PROPN
dti-1319	500	2	.	.	PUNCT
dti-1319	500	3	ophthalmol	ophthalmol	PROPN
dti-1319	500	4	,	,	PUNCT
dti-1319	500	5	229:389–94	229:389–94	NUM
dti-1319	500	6	.	.	PUNCT
dti-1319	501	1	lang	lang	PROPN
dti-1319	501	2	,	,	PUNCT
dti-1319	501	3	j.c	j.c	PROPN
dti-1319	501	4	.	.	PROPN
dti-1319	501	5	1995	1995	NUM
dti-1319	501	6	.	.	PUNCT
dti-1319	502	1	ocular	ocular	ADJ
dti-1319	502	2	drug	drug	NOUN
dti-1319	502	3	delivery	delivery	NOUN
dti-1319	502	4	:	:	PUNCT
dti-1319	502	5	conventional	conventional	ADJ
dti-1319	502	6	ocular	ocular	ADJ
dti-1319	502	7	formulations	formulation	NOUN
dti-1319	502	8	.	.	PUNCT
dti-1319	503	1	adv	adv	PROPN
dti-1319	503	2	.	.	PUNCT
dti-1319	503	3	drug	drug	PROPN
dti-1319	503	4	deliv	deliv	PROPN
dti-1319	503	5	.	.	PUNCT
dti-1319	504	1	rev	rev	PROPN
dti-1319	504	2	.	.	PROPN
dti-1319	504	3	,	,	PUNCT
dti-1319	504	4	16:39–43	16:39–43	NUM
dti-1319	504	5	.	.	PUNCT
dti-1319	505	1	langer	langer	PROPN
dti-1319	505	2	,	,	PUNCT
dti-1319	505	3	r.	r.	PROPN
dti-1319	505	4	1998	1998	NUM
dti-1319	505	5	.	.	PUNCT
dti-1319	506	1	drug	drug	NOUN
dti-1319	506	2	delivery	delivery	NOUN
dti-1319	506	3	and	and	CCONJ
dti-1319	506	4	targeting	targeting	NOUN
dti-1319	506	5	.	.	PUNCT
dti-1319	507	1	nature	nature	NOUN
dti-1319	507	2	,	,	PUNCT
dti-1319	507	3	392:5–10	392:5–10	X
dti-1319	507	4	.	.	PUNCT
dti-1319	508	1	li	li	PROPN
dti-1319	508	2	,	,	PUNCT
dti-1319	508	3	b.j	b.j	PROPN
dti-1319	508	4	.	.	PROPN
dti-1319	508	5	,	,	PUNCT
dti-1319	508	6	tang	tang	PROPN
dti-1319	508	7	,	,	PUNCT
dti-1319	508	8	q.	q.	PROPN
dti-1319	508	9	,	,	PUNCT
dti-1319	508	10	cheng	cheng	PROPN
dti-1319	508	11	,	,	PUNCT
dti-1319	508	12	d.	d.	PROPN
dti-1319	508	13	,	,	PUNCT
dti-1319	508	14	et	et	PROPN
dti-1319	508	15	al	al	PROPN
dti-1319	508	16	.	.	PROPN
dti-1319	508	17	2005	2005	NUM
dti-1319	508	18	.	.	PUNCT
dti-1319	509	1	using	use	VERB
dti-1319	509	2	sirna	sirna	PROPN
dti-1319	509	3	in	in	ADP
dti-1319	509	4	prophylactic	prophylactic	ADJ
dti-1319	509	5	and	and	CCONJ
dti-1319	509	6	therapeutic	therapeutic	ADJ
dti-1319	509	7	regimens	regimen	NOUN
dti-1319	509	8	against	against	ADP
dti-1319	509	9	sars	sars	PROPN
dti-1319	509	10	coronavirus	coronavirus	PROPN
dti-1319	509	11	in	in	ADP
dti-1319	509	12	rhesus	rhesus	NOUN
dti-1319	509	13	macaque	macaque	NOUN
dti-1319	509	14	.	.	PUNCT
dti-1319	510	1	nat	nat	PROPN
dti-1319	510	2	.	.	PUNCT
dti-1319	511	1	med	med	PROPN
dti-1319	511	2	.	.	PROPN
dti-1319	511	3	,	,	PUNCT
dti-1319	511	4	11:944–51	11:944–51	NUM
dti-1319	511	5	.	.	PUNCT
dti-1319	512	1	lorenz	lorenz	PROPN
dti-1319	512	2	,	,	PUNCT
dti-1319	512	3	c.	c.	PROPN
dti-1319	512	4	,	,	PUNCT
dti-1319	512	5	hadwiger	hadwiger	PROPN
dti-1319	512	6	,	,	PUNCT
dti-1319	512	7	p.	p.	PROPN
dti-1319	512	8	,	,	PUNCT
dti-1319	512	9	john	john	PROPN
dti-1319	512	10	,	,	PUNCT
dti-1319	512	11	m.	m.	NOUN
dti-1319	512	12	,	,	PUNCT
dti-1319	512	13	et	et	PROPN
dti-1319	512	14	al	al	PROPN
dti-1319	512	15	.	.	PROPN
dti-1319	512	16	2004	2004	NUM
dti-1319	512	17	.	.	PUNCT
dti-1319	513	1	steroid	steroid	NOUN
dti-1319	513	2	and	and	CCONJ
dti-1319	513	3	lipid	lipid	NOUN
dti-1319	513	4	conjugates	conjugate	NOUN
dti-1319	513	5	of	of	ADP
dti-1319	513	6	sirnas	sirna	NOUN
dti-1319	513	7	to	to	PART
dti-1319	513	8	enhance	enhance	VERB
dti-1319	513	9	cellular	cellular	ADJ
dti-1319	513	10	uptake	uptake	NOUN
dti-1319	513	11	and	and	CCONJ
dti-1319	513	12	gene	gene	NOUN
dti-1319	513	13	silencing	silence	VERB
dti-1319	513	14	in	in	ADP
dti-1319	513	15	liver	liver	NOUN
dti-1319	513	16	cells	cell	NOUN
dti-1319	513	17	.	.	PUNCT
dti-1319	514	1	bioorg	bioorg	PROPN
dti-1319	514	2	.	.	PUNCT
dti-1319	515	1	med	med	PROPN
dti-1319	515	2	.	.	PROPN
dti-1319	515	3	chem	chem	PROPN
dti-1319	515	4	.	.	PUNCT
dti-1319	516	1	lett	lett	PROPN
dti-1319	516	2	.	.	PROPN
dti-1319	516	3	,	,	PUNCT
dti-1319	516	4	14:4975–7	14:4975–7	NUM
dti-1319	516	5	.	.	PUNCT
dti-1319	517	1	lupold	lupold	PROPN
dti-1319	517	2	,	,	PUNCT
dti-1319	517	3	s.e	s.e	PROPN
dti-1319	517	4	.	.	PROPN
dti-1319	517	5	,	,	PUNCT
dti-1319	517	6	hicke	hicke	PROPN
dti-1319	517	7	,	,	PUNCT
dti-1319	517	8	b.j	b.j	PROPN
dti-1319	517	9	.	.	PROPN
dti-1319	517	10	,	,	PUNCT
dti-1319	517	11	lin	lin	PROPN
dti-1319	517	12	,	,	PUNCT
dti-1319	517	13	y.	y.	PROPN
dti-1319	517	14	,	,	PUNCT
dti-1319	517	15	et	et	PROPN
dti-1319	517	16	al	al	PROPN
dti-1319	517	17	.	.	PROPN
dti-1319	517	18	2002	2002	NUM
dti-1319	517	19	.	.	PUNCT
dti-1319	518	1	identifi	identifi	PROPN
dti-1319	518	2	cation	cation	NOUN
dti-1319	518	3	and	and	CCONJ
dti-1319	518	4	characterization	characterization	NOUN
dti-1319	518	5	of	of	ADP
dti-1319	518	6	nuclease	nuclease	NOUN
dti-1319	518	7	-	-	PUNCT
dti-1319	518	8	stabilized	stabilize	VERB
dti-1319	518	9	rna	rna	NOUN
dti-1319	518	10	molecules	molecule	NOUN
dti-1319	518	11	that	that	PRON
dti-1319	518	12	bind	bind	VERB
dti-1319	518	13	human	human	ADJ
dti-1319	518	14	prostate	prostate	NOUN
dti-1319	518	15	cancer	cancer	NOUN
dti-1319	518	16	cells	cell	NOUN
dti-1319	518	17	via	via	ADP
dti-1319	518	18	the	the	DET
dti-1319	518	19	prostate	prostate	NOUN
dti-1319	518	20	-	-	PUNCT
dti-1319	518	21	specifi	specifi	PROPN
dti-1319	518	22	c	c	PROPN
dti-1319	518	23	membrane	membrane	NOUN
dti-1319	518	24	antigen	antigen	ADV
dti-1319	518	25	.	.	PUNCT
dti-1319	519	1	cancer	cancer	NOUN
dti-1319	519	2	res	re	NOUN
dti-1319	519	3	.	.	PROPN
dti-1319	519	4	,	,	PUNCT
dti-1319	519	5	62:4029–33	62:4029–33	PROPN
dti-1319	519	6	.	.	PUNCT
dti-1319	520	1	ma	ma	PROPN
dti-1319	520	2	,	,	PUNCT
dti-1319	520	3	p.x	p.x	PROPN
dti-1319	520	4	.	.	PROPN
dti-1319	520	5	and	and	CCONJ
dti-1319	520	6	choi	choi	PROPN
dti-1319	520	7	,	,	PUNCT
dti-1319	520	8	j.w	j.w	PROPN
dti-1319	520	9	.	.	PROPN
dti-1319	520	10	2001	2001	NUM
dti-1319	520	11	.	.	PUNCT
dti-1319	521	1	biodegradable	biodegradable	ADJ
dti-1319	521	2	polymer	polymer	NOUN
dti-1319	521	3	scaffolds	scaffold	NOUN
dti-1319	521	4	with	with	ADP
dti-1319	521	5	welldefi	welldefi	PROPN
dti-1319	521	6	ned	ne	VERB
dti-1319	521	7	interconnected	interconnect	VERB
dti-1319	521	8	spherical	spherical	ADJ
dti-1319	521	9	pore	pore	ADJ
dti-1319	521	10	network	network	NOUN
dti-1319	521	11	.	.	PUNCT
dti-1319	522	1	tissue	tissue	NOUN
dti-1319	522	2	eng	eng	PROPN
dti-1319	522	3	.	.	PROPN
dti-1319	522	4	,	,	PUNCT
dti-1319	522	5	7:23–33	7:23–33	PROPN
dti-1319	522	6	.	.	PUNCT
dti-1319	523	1	mallery	mallery	PROPN
dti-1319	523	2	,	,	PUNCT
dti-1319	523	3	s.r	s.r	PROPN
dti-1319	523	4	.	.	PROPN
dti-1319	523	5	,	,	PUNCT
dti-1319	523	6	kang	kang	PROPN
dti-1319	523	7	,	,	PUNCT
dti-1319	523	8	p.p	p.p	PROPN
dti-1319	523	9	.	.	PROPN
dti-1319	523	10	,	,	PUNCT
dti-1319	523	11	ness	ness	PROPN
dti-1319	523	12	,	,	PUNCT
dti-1319	523	13	g.m	g.m	PROPN
dti-1319	523	14	.	.	PROPN
dti-1319	523	15	,	,	PUNCT
dti-1319	523	16	et	et	PROPN
dti-1319	523	17	al	al	PROPN
dti-1319	523	18	.	.	PROPN
dti-1319	523	19	2000	2000	NUM
dti-1319	523	20	.	.	PUNCT
dti-1319	524	1	controlled	control	VERB
dti-1319	524	2	-	-	PUNCT
dti-1319	524	3	release	release	NOUN
dti-1319	524	4	of	of	ADP
dti-1319	524	5	doxorubicin	doxorubicin	PROPN
dti-1319	524	6	from	from	ADP
dti-1319	524	7	poly(lactic	poly(lactic	PROPN
dti-1319	524	8	-	-	PUNCT
dti-1319	524	9	co	co	NOUN
dti-1319	524	10	-	-	NOUN
dti-1319	524	11	glycolic	glycolic	NOUN
dti-1319	524	12	)	)	PUNCT
dti-1319	524	13	microspheres	microsphere	NOUN
dti-1319	524	14	signifi	signifi	NOUN
dti-1319	524	15	cantly	cantly	ADV
dti-1319	524	16	enhances	enhance	VERB
dti-1319	524	17	cytotoxicity	cytotoxicity	NOUN
dti-1319	524	18	against	against	ADP
dti-1319	524	19	cultured	cultured	ADJ
dti-1319	524	20	aids	aid	NOUN
dti-1319	524	21	-	-	PUNCT
dti-1319	524	22	related	relate	VERB
dti-1319	524	23	kaposi	kaposi	PROPN
dti-1319	524	24	’s	’s	PART
dti-1319	524	25	sarcoma	sarcoma	NOUN
dti-1319	524	26	cells	cell	NOUN
dti-1319	524	27	.	.	PUNCT
dti-1319	525	1	anticancer	anticancer	NOUN
dti-1319	525	2	res	re	NOUN
dti-1319	525	3	.	.	PROPN
dti-1319	525	4	,	,	PUNCT
dti-1319	525	5	20:2817–25	20:2817–25	NUM
dti-1319	525	6	.	.	PUNCT
dti-1319	526	1	martinez	martinez	PROPN
dti-1319	526	2	,	,	PUNCT
dti-1319	526	3	m.a	m.a	PROPN
dti-1319	526	4	.	.	PROPN
dti-1319	526	5	,	,	PUNCT
dti-1319	526	6	gutierrez	gutierrez	PROPN
dti-1319	526	7	,	,	PUNCT
dti-1319	526	8	a.	a.	PROPN
dti-1319	526	9	,	,	PUNCT
dti-1319	526	10	armand	armand	NOUN
dti-1319	526	11	-	-	PUNCT
dti-1319	526	12	ugon	ugon	PROPN
dti-1319	526	13	,	,	PUNCT
dti-1319	526	14	m.	m.	NOUN
dti-1319	526	15	,	,	PUNCT
dti-1319	526	16	et	et	PROPN
dti-1319	526	17	al	al	PROPN
dti-1319	526	18	.	.	PROPN
dti-1319	526	19	2002	2002	NUM
dti-1319	526	20	.	.	PUNCT
dti-1319	527	1	suppression	suppression	NOUN
dti-1319	527	2	of	of	ADP
dti-1319	527	3	chemokine	chemokine	ADJ
dti-1319	527	4	receptor	receptor	NOUN
dti-1319	527	5	expression	expression	NOUN
dti-1319	527	6	by	by	ADP
dti-1319	527	7	rna	rna	NOUN
dti-1319	527	8	interference	interference	NOUN
dti-1319	527	9	allows	allow	VERB
dti-1319	527	10	for	for	ADP
dti-1319	527	11	inhibition	inhibition	NOUN
dti-1319	527	12	of	of	ADP
dti-1319	527	13	hiv-1	hiv-1	ADJ
dti-1319	527	14	replication	replication	NOUN
dti-1319	527	15	.	.	PUNCT
dti-1319	528	1	aids	aids	PROPN
dti-1319	528	2	,	,	PUNCT
dti-1319	528	3	16:2385–90	16:2385–90	NUM
dti-1319	528	4	.	.	PUNCT
dti-1319	529	1	mcmanus	mcmanus	PROPN
dti-1319	529	2	,	,	PUNCT
dti-1319	529	3	m.t	m.t	PROPN
dti-1319	529	4	.	.	PROPN
dti-1319	529	5	and	and	CCONJ
dti-1319	529	6	sharp	sharp	ADJ
dti-1319	529	7	,	,	PUNCT
dti-1319	529	8	p.a	p.a	PROPN
dti-1319	529	9	.	.	PROPN
dti-1319	529	10	2002	2002	NUM
dti-1319	529	11	.	.	PUNCT
dti-1319	530	1	gene	gene	NOUN
dti-1319	530	2	silencing	silence	VERB
dti-1319	530	3	in	in	ADP
dti-1319	530	4	mammals	mammal	NOUN
dti-1319	530	5	by	by	ADP
dti-1319	530	6	small	small	ADJ
dti-1319	530	7	interfering	interfere	VERB
dti-1319	530	8	rnas	rna	NOUN
dti-1319	530	9	.	.	PUNCT
dti-1319	531	1	nat	nat	PROPN
dti-1319	531	2	.	.	PUNCT
dti-1319	532	1	rev	rev	PROPN
dti-1319	532	2	.	.	PROPN
dti-1319	532	3	genet	genet	PROPN
dti-1319	532	4	.	.	PUNCT
dti-1319	532	5	,	,	PUNCT
dti-1319	533	1	3:737–47	3:737–47	X
dti-1319	533	2	.	.	PUNCT
dti-1319	533	3	mcnamara	mcnamara	PROPN
dti-1319	533	4	,	,	PUNCT
dti-1319	533	5	j.o	j.o	PROPN
dti-1319	533	6	.	.	PROPN
dti-1319	533	7	,	,	PUNCT
dti-1319	533	8	2nd	2nd	PROPN
dti-1319	533	9	,	,	PUNCT
dti-1319	533	10	andrechek	andrechek	PROPN
dti-1319	533	11	,	,	PUNCT
dti-1319	533	12	e.r	e.r	PROPN
dti-1319	533	13	.	.	PROPN
dti-1319	533	14	,	,	PUNCT
dti-1319	533	15	wang	wang	PROPN
dti-1319	533	16	,	,	PUNCT
dti-1319	533	17	y.	y.	PROPN
dti-1319	533	18	,	,	PUNCT
dti-1319	533	19	et	et	PROPN
dti-1319	533	20	al	al	PROPN
dti-1319	533	21	.	.	PROPN
dti-1319	533	22	2006	2006	NUM
dti-1319	533	23	.	.	PUNCT
dti-1319	534	1	cell	cell	NOUN
dti-1319	534	2	typespecifi	typespecifi	NOUN
dti-1319	534	3	c	c	NOUN
dti-1319	534	4	delivery	delivery	NOUN
dti-1319	534	5	of	of	ADP
dti-1319	534	6	sirnas	sirna	NOUN
dti-1319	534	7	with	with	ADP
dti-1319	534	8	aptamer	aptamer	PROPN
dti-1319	534	9	-	-	PUNCT
dti-1319	534	10	sirna	sirna	PROPN
dti-1319	534	11	chimeras	chimeras	PROPN
dti-1319	534	12	.	.	PUNCT
dti-1319	535	1	nat	nat	PROPN
dti-1319	535	2	.	.	PUNCT
dti-1319	536	1	biotechnol	biotechnol	PROPN
dti-1319	536	2	.	.	PUNCT
dti-1319	536	3	,	,	PUNCT
dti-1319	536	4	24:1005–15	24:1005–15	NUM
dti-1319	536	5	.	.	PUNCT
dti-1319	537	1	meister	meister	PROPN
dti-1319	537	2	,	,	PUNCT
dti-1319	537	3	g.	g.	PROPN
dti-1319	537	4	,	,	PUNCT
dti-1319	537	5	landthaler	landthaler	NOUN
dti-1319	537	6	,	,	PUNCT
dti-1319	537	7	m.	m.	NOUN
dti-1319	537	8	,	,	PUNCT
dti-1319	537	9	patkaniowska	patkaniowska	ADJ
dti-1319	537	10	,	,	PUNCT
dti-1319	537	11	a.	a.	NOUN
dti-1319	537	12	,	,	PUNCT
dti-1319	537	13	et	et	PROPN
dti-1319	537	14	al	al	PROPN
dti-1319	537	15	.	.	PROPN
dti-1319	537	16	2004	2004	NUM
dti-1319	537	17	.	.	PUNCT
dti-1319	538	1	human	human	ADJ
dti-1319	538	2	argonaute2	argonaute2	PROPN
dti-1319	538	3	mediates	mediates	PROPN
dti-1319	538	4	rna	rna	NOUN
dti-1319	538	5	cleavage	cleavage	NOUN
dti-1319	538	6	tarfeted	tarfete	VERB
dti-1319	538	7	by	by	ADP
dti-1319	538	8	mirnas	mirna	NOUN
dti-1319	538	9	and	and	CCONJ
dti-1319	538	10	sirnas	sirna	NOUN
dti-1319	538	11	.	.	PUNCT
dti-1319	539	1	mol	mol	PROPN
dti-1319	539	2	.	.	PROPN
dti-1319	539	3	cell	cell	NOUN
dti-1319	539	4	,	,	PUNCT
dti-1319	539	5	15:185–97	15:185–97	NUM
dti-1319	539	6	.	.	PUNCT
dti-1319	540	1	miller	miller	PROPN
dti-1319	540	2	,	,	PUNCT
dti-1319	540	3	v.m	v.m	PROPN
dti-1319	540	4	.	.	PROPN
dti-1319	540	5	,	,	PUNCT
dti-1319	540	6	paulson	paulson	PROPN
dti-1319	540	7	,	,	PUNCT
dti-1319	540	8	h.l	h.l	PROPN
dti-1319	540	9	.	.	PROPN
dti-1319	540	10	and	and	CCONJ
dti-1319	540	11	gonzalez	gonzalez	PROPN
dti-1319	540	12	-	-	PUNCT
dti-1319	540	13	alegre	alegre	PROPN
dti-1319	540	14	,	,	PUNCT
dti-1319	540	15	p.	p.	NOUN
dti-1319	540	16	2005	2005	NUM
dti-1319	540	17	.	.	PUNCT
dti-1319	541	1	rna	rna	NOUN
dti-1319	541	2	interference	interference	NOUN
dti-1319	541	3	in	in	ADP
dti-1319	541	4	neuroscience	neuroscience	NOUN
dti-1319	541	5	:	:	PUNCT
dti-1319	541	6	progress	progress	NOUN
dti-1319	541	7	and	and	CCONJ
dti-1319	541	8	challenges	challenge	NOUN
dti-1319	541	9	.	.	PUNCT
dti-1319	542	1	cell	cell	NOUN
dti-1319	542	2	mol	mol	PROPN
dti-1319	542	3	.	.	PUNCT
dti-1319	543	1	neurobiol	neurobiol	PROPN
dti-1319	543	2	.	.	PUNCT
dti-1319	543	3	,	,	PUNCT
dti-1319	543	4	25:1195–207	25:1195–207	PROPN
dti-1319	543	5	.	.	PUNCT
dti-1319	544	1	minakuchi	minakuchi	PROPN
dti-1319	544	2	,	,	PUNCT
dti-1319	544	3	y.	y.	PROPN
dti-1319	544	4	,	,	PUNCT
dti-1319	544	5	takeshita	takeshita	PROPN
dti-1319	544	6	,	,	PUNCT
dti-1319	544	7	f.	f.	PROPN
dti-1319	544	8	,	,	PUNCT
dti-1319	544	9	kosaka	kosaka	PROPN
dti-1319	544	10	,	,	PUNCT
dti-1319	544	11	n.	n.	PROPN
dti-1319	544	12	,	,	PUNCT
dti-1319	544	13	et	et	PROPN
dti-1319	544	14	al	al	PROPN
dti-1319	544	15	.	.	PROPN
dti-1319	544	16	2004	2004	NUM
dti-1319	544	17	.	.	PUNCT
dti-1319	545	1	atelocollagen	atelocollagen	ADV
dti-1319	545	2	-	-	PUNCT
dti-1319	545	3	mediated	mediate	VERB
dti-1319	545	4	synthetic	synthetic	ADJ
dti-1319	545	5	small	small	ADJ
dti-1319	545	6	interfering	interfere	VERB
dti-1319	545	7	rna	rna	NOUN
dti-1319	545	8	delivery	delivery	NOUN
dti-1319	545	9	for	for	ADP
dti-1319	545	10	effective	effective	ADJ
dti-1319	545	11	gene	gene	NOUN
dti-1319	545	12	silencing	silence	VERB
dti-1319	545	13	in	in	ADP
dti-1319	545	14	vitro	vitro	X
dti-1319	545	15	and	and	CCONJ
dti-1319	545	16	in	in	ADP
dti-1319	545	17	vivo	vivo	NOUN
dti-1319	545	18	.	.	PUNCT
dti-1319	546	1	nucleic	nucleic	ADJ
dti-1319	546	2	acids	acid	NOUN
dti-1319	546	3	res	re	NOUN
dti-1319	546	4	.	.	PUNCT
dti-1319	546	5	,	,	PUNCT
dti-1319	546	6	32	32	NUM
dti-1319	546	7	:	:	PUNCT
dti-1319	546	8	e109	e109	PROPN
dti-1319	546	9	.	.	PUNCT
dti-1319	547	1	moritera	moritera	NOUN
dti-1319	547	2	,	,	PUNCT
dti-1319	547	3	t.	t.	PROPN
dti-1319	547	4	,	,	PUNCT
dti-1319	547	5	ogura	ogura	PROPN
dti-1319	547	6	,	,	PUNCT
dti-1319	547	7	y.	y.	PROPN
dti-1319	547	8	,	,	PUNCT
dti-1319	547	9	honda	honda	NOUN
dti-1319	547	10	,	,	PUNCT
dti-1319	547	11	y.	y.	PROPN
dti-1319	547	12	,	,	PUNCT
dti-1319	547	13	et	et	PROPN
dti-1319	547	14	al	al	PROPN
dti-1319	547	15	.	.	PROPN
dti-1319	547	16	1991	1991	NUM
dti-1319	547	17	.	.	PUNCT
dti-1319	548	1	microspheres	microsphere	NOUN
dti-1319	548	2	of	of	ADP
dti-1319	548	3	biodegradable	biodegradable	ADJ
dti-1319	548	4	polymers	polymer	NOUN
dti-1319	548	5	as	as	ADP
dti-1319	548	6	a	a	DET
dti-1319	548	7	drug	drug	NOUN
dti-1319	548	8	-	-	PUNCT
dti-1319	548	9	delivery	delivery	NOUN
dti-1319	548	10	system	system	NOUN
dti-1319	548	11	in	in	ADP
dti-1319	548	12	the	the	DET
dti-1319	548	13	vitreous	vitreous	ADJ
dti-1319	548	14	.	.	PUNCT
dti-1319	549	1	invest	invest	VERB
dti-1319	549	2	ophthalmol	ophthalmol	NOUN
dti-1319	549	3	.	.	PUNCT
dti-1319	550	1	vis	vis	X
dti-1319	550	2	.	.	PUNCT
dti-1319	551	1	sci	sci	PROPN
dti-1319	551	2	.	.	PROPN
dti-1319	551	3	,	,	PUNCT
dti-1319	551	4	32:1785–90	32:1785–90	NUM
dti-1319	551	5	.	.	PUNCT
dti-1319	552	1	morrissey	morrissey	PROPN
dti-1319	552	2	,	,	PUNCT
dti-1319	552	3	d.v	d.v	PROPN
dti-1319	552	4	.	.	PROPN
dti-1319	552	5	,	,	PUNCT
dti-1319	552	6	lockridge	lockridge	PROPN
dti-1319	552	7	,	,	PUNCT
dti-1319	552	8	j.a	j.a	PROPN
dti-1319	552	9	.	.	PROPN
dti-1319	552	10	,	,	PUNCT
dti-1319	552	11	shaw	shaw	PROPN
dti-1319	552	12	,	,	PUNCT
dti-1319	552	13	l.	l.	PROPN
dti-1319	552	14	,	,	PUNCT
dti-1319	552	15	et	et	PROPN
dti-1319	552	16	al	al	PROPN
dti-1319	552	17	.	.	PROPN
dti-1319	552	18	2005	2005	NUM
dti-1319	552	19	.	.	PUNCT
dti-1319	553	1	potent	potent	NOUN
dti-1319	553	2	and	and	CCONJ
dti-1319	553	3	persistent	persistent	ADJ
dti-1319	553	4	in	in	ADP
dti-1319	553	5	vivo	vivo	ADJ
dti-1319	553	6	anti	anti	ADJ
dti-1319	553	7	-	-	ADJ
dti-1319	553	8	hbv	hbv	ADJ
dti-1319	553	9	activity	activity	NOUN
dti-1319	553	10	of	of	ADP
dti-1319	553	11	chemically	chemically	ADV
dti-1319	553	12	modifi	modifi	PROPN
dti-1319	553	13	ed	ed	PROPN
dti-1319	553	14	sirnas	sirnas	PROPN
dti-1319	553	15	.	.	PUNCT
dti-1319	554	1	nat	nat	PROPN
dti-1319	554	2	.	.	PUNCT
dti-1319	555	1	biotechnol	biotechnol	PROPN
dti-1319	555	2	.	.	PUNCT
dti-1319	556	1	,	,	PUNCT
dti-1319	556	2	23:1002–7	23:1002–7	X
dti-1319	556	3	.	.	PUNCT
dti-1319	557	1	murchison	murchison	PROPN
dti-1319	557	2	,	,	PUNCT
dti-1319	557	3	e.p	e.p	PROPN
dti-1319	557	4	.	.	PROPN
dti-1319	557	5	,	,	PUNCT
dti-1319	557	6	partridge	partridge	PROPN
dti-1319	557	7	,	,	PUNCT
dti-1319	557	8	j.f	j.f	PROPN
dti-1319	557	9	.	.	PROPN
dti-1319	557	10	,	,	PUNCT
dti-1319	557	11	tam	tam	PROPN
dti-1319	557	12	,	,	PUNCT
dti-1319	557	13	o.h	o.h	PROPN
dti-1319	557	14	.	.	PROPN
dti-1319	557	15	,	,	PUNCT
dti-1319	557	16	et	et	PROPN
dti-1319	557	17	al	al	PROPN
dti-1319	557	18	.	.	PROPN
dti-1319	557	19	2005	2005	NUM
dti-1319	557	20	.	.	PUNCT
dti-1319	558	1	characterization	characterization	NOUN
dti-1319	558	2	of	of	ADP
dti-1319	558	3	dicer	dicer	NOUN
dti-1319	558	4	-	-	PUNCT
dti-1319	558	5	defi	defi	NOUN
dti-1319	558	6	cient	cient	NOUN
dti-1319	558	7	murine	murine	ADJ
dti-1319	558	8	embryonic	embryonic	ADJ
dti-1319	558	9	stem	stem	NOUN
dti-1319	558	10	cells	cell	NOUN
dti-1319	558	11	.	.	PUNCT
dti-1319	559	1	proc	proc	NOUN
dti-1319	559	2	.	.	PUNCT
dti-1319	560	1	natl	natl	PROPN
dti-1319	560	2	.	.	PUNCT
dti-1319	561	1	acad	acad	PROPN
dti-1319	561	2	.	.	PUNCT
dti-1319	562	1	sci	sci	PROPN
dti-1319	562	2	.	.	PUNCT
dti-1319	562	3	u.s.a	u.s.a	PROPN
dti-1319	562	4	.	.	PROPN
dti-1319	562	5	,	,	PUNCT
dti-1319	562	6	102:12135–40	102:12135–40	NUM
dti-1319	562	7	.	.	PUNCT
dti-1319	563	1	nakano	nakano	PROPN
dti-1319	563	2	,	,	PUNCT
dti-1319	563	3	h.	h.	PROPN
dti-1319	563	4	,	,	PUNCT
dti-1319	563	5	amemiya	amemiya	PROPN
dti-1319	563	6	,	,	PUNCT
dti-1319	563	7	s.	s.	PROPN
dti-1319	563	8	,	,	PUNCT
dti-1319	563	9	shiokawa	shiokawa	PROPN
dti-1319	563	10	,	,	PUNCT
dti-1319	563	11	k.	k.	PROPN
dti-1319	563	12	,	,	PUNCT
dti-1319	563	13	et	et	PROPN
dti-1319	563	14	al	al	PROPN
dti-1319	563	15	.	.	PROPN
dti-1319	563	16	2000	2000	NUM
dti-1319	563	17	.	.	PUNCT
dti-1319	564	1	rna	rna	NOUN
dti-1319	564	2	interference	interference	NOUN
dti-1319	564	3	for	for	ADP
dti-1319	564	4	the	the	DET
dti-1319	564	5	organizer	organizer	NOUN
dti-1319	564	6	-	-	PUNCT
dti-1319	564	7	specifi	specifi	PROPN
dti-1319	564	8	c	c	PROPN
dti-1319	564	9	gene	gene	NOUN
dti-1319	564	10	xlim-1	xlim-1	NUM
dti-1319	564	11	in	in	ADP
dti-1319	564	12	xenopus	xenopus	PROPN
dti-1319	564	13	embryos	embryos	PROPN
dti-1319	564	14	.	.	PUNCT
dti-1319	565	1	biochem	biochem	PROPN
dti-1319	565	2	.	.	PUNCT
dti-1319	566	1	biophys	biophy	NOUN
dti-1319	566	2	.	.	PUNCT
dti-1319	567	1	res	re	NOUN
dti-1319	567	2	.	.	PUNCT
dti-1319	568	1	commun	commun	PROPN
dti-1319	568	2	.	.	PROPN
dti-1319	569	1	,	,	PUNCT
dti-1319	569	2	274:434–9	274:434–9	PROPN
dti-1319	569	3	.	.	PUNCT
dti-1319	570	1	ng	ng	PROPN
dti-1319	570	2	,	,	PUNCT
dti-1319	570	3	e.w	e.w	PROPN
dti-1319	570	4	.	.	PROPN
dti-1319	570	5	,	,	PUNCT
dti-1319	570	6	shima	shima	PROPN
dti-1319	570	7	,	,	PUNCT
dti-1319	570	8	d.t	d.t	PROPN
dti-1319	570	9	.	.	PROPN
dti-1319	570	10	,	,	PUNCT
dti-1319	570	11	calias	calia	NOUN
dti-1319	570	12	,	,	PUNCT
dti-1319	570	13	p.	p.	PROPN
dti-1319	570	14	,	,	PUNCT
dti-1319	570	15	et	et	PROPN
dti-1319	570	16	al	al	PROPN
dti-1319	570	17	.	.	PROPN
dti-1319	570	18	2006	2006	NUM
dti-1319	570	19	.	.	PUNCT
dti-1319	571	1	pegaptanib	pegaptanib	NOUN
dti-1319	571	2	,	,	PUNCT
dti-1319	571	3	a	a	DET
dti-1319	571	4	targeted	target	VERB
dti-1319	571	5	antivegf	antivegf	ADJ
dti-1319	571	6	aptamer	aptamer	NOUN
dti-1319	571	7	for	for	ADP
dti-1319	571	8	ocular	ocular	ADJ
dti-1319	571	9	vascular	vascular	ADJ
dti-1319	571	10	disease	disease	NOUN
dti-1319	571	11	.	.	PUNCT
dti-1319	572	1	nat	nat	PROPN
dti-1319	572	2	.	.	PUNCT
dti-1319	573	1	rev	rev	PROPN
dti-1319	573	2	.	.	PROPN
dti-1319	573	3	drug	drug	PROPN
dti-1319	573	4	.	.	PUNCT
dti-1319	574	1	discov	discov	PROPN
dti-1319	574	2	.	.	PUNCT
dti-1319	574	3	,	,	PUNCT
dti-1319	575	1	5:123–32	5:123–32	PROPN
dti-1319	575	2	.	.	PUNCT
dti-1319	575	3	niu	niu	PROPN
dti-1319	575	4	,	,	PUNCT
dti-1319	575	5	x.y	x.y	PROPN
dti-1319	575	6	.	.	PROPN
dti-1319	575	7	,	,	PUNCT
dti-1319	575	8	peng	peng	PROPN
dti-1319	575	9	,	,	PUNCT
dti-1319	575	10	z.l	z.l	PROPN
dti-1319	575	11	.	.	PROPN
dti-1319	575	12	,	,	PUNCT
dti-1319	575	13	duan	duan	PROPN
dti-1319	575	14	,	,	PUNCT
dti-1319	575	15	w.q	w.q	PROPN
dti-1319	575	16	.	.	PROPN
dti-1319	575	17	,	,	PUNCT
dti-1319	575	18	et	et	PROPN
dti-1319	575	19	al	al	PROPN
dti-1319	575	20	.	.	PROPN
dti-1319	575	21	2006	2006	NUM
dti-1319	575	22	.	.	PUNCT
dti-1319	576	1	inhibition	inhibition	NOUN
dti-1319	576	2	of	of	ADP
dti-1319	576	3	hpv	hpv	ADJ
dti-1319	576	4	16	16	NUM
dti-1319	576	5	e6	e6	PROPN
dti-1319	576	6	oncogene	oncogene	NOUN
dti-1319	576	7	expression	expression	NOUN
dti-1319	576	8	by	by	ADP
dti-1319	576	9	rna	rna	NOUN
dti-1319	576	10	interference	interference	NOUN
dti-1319	576	11	in	in	ADP
dti-1319	576	12	vitro	vitro	X
dti-1319	576	13	and	and	CCONJ
dti-1319	576	14	in	in	ADP
dti-1319	576	15	vivo	vivo	NOUN
dti-1319	576	16	.	.	PUNCT
dti-1319	577	1	int	int	NOUN
dti-1319	577	2	.	.	PUNCT
dti-1319	578	1	j.	j.	PROPN
dti-1319	578	2	gynecol	gynecol	PROPN
dti-1319	578	3	.	.	PUNCT
dti-1319	579	1	cancer	cancer	NOUN
dti-1319	579	2	,	,	PUNCT
dti-1319	579	3	16	16	NUM
dti-1319	579	4	,	,	PUNCT
dti-1319	579	5	743–51	743–51	PROPN
dti-1319	579	6	.	.	PUNCT
dti-1319	580	1	nykänen	nykänen	NOUN
dti-1319	580	2	,	,	PUNCT
dti-1319	580	3	a.	a.	NOUN
dti-1319	580	4	,	,	PUNCT
dti-1319	580	5	haley	haley	NOUN
dti-1319	580	6	,	,	PUNCT
dti-1319	580	7	b.	b.	PROPN
dti-1319	580	8	and	and	CCONJ
dti-1319	580	9	zamore	zamore	PROPN
dti-1319	580	10	,	,	PUNCT
dti-1319	580	11	p.d	p.d	PROPN
dti-1319	580	12	.	.	PROPN
dti-1319	580	13	2001	2001	NUM
dti-1319	580	14	.	.	PUNCT
dti-1319	581	1	atp	atp	NOUN
dti-1319	581	2	requirements	requirement	NOUN
dti-1319	581	3	and	and	CCONJ
dti-1319	581	4	small	small	ADJ
dti-1319	581	5	interfering	interfere	VERB
dti-1319	581	6	rna	rna	NOUN
dti-1319	581	7	structure	structure	NOUN
dti-1319	581	8	in	in	ADP
dti-1319	581	9	the	the	DET
dti-1319	581	10	rna	rna	NOUN
dti-1319	581	11	interference	interference	NOUN
dti-1319	581	12	pathway	pathway	NOUN
dti-1319	581	13	.	.	PUNCT
dti-1319	582	1	cell	cell	NOUN
dti-1319	582	2	,	,	PUNCT
dti-1319	582	3	107:309–21	107:309–21	PROPN
dti-1319	582	4	.	.	PUNCT
dti-1319	582	5	olsen	olsen	PROPN
dti-1319	582	6	,	,	PUNCT
dti-1319	582	7	p.h	p.h	PROPN
dti-1319	582	8	.	.	PROPN
dti-1319	582	9	and	and	CCONJ
dti-1319	582	10	ambros	ambros	PROPN
dti-1319	582	11	,	,	PUNCT
dti-1319	582	12	v.	v.	ADP
dti-1319	582	13	1999	1999	NUM
dti-1319	582	14	.	.	PUNCT
dti-1319	583	1	the	the	DET
dti-1319	583	2	lin-4	lin-4	ADJ
dti-1319	583	3	regulatory	regulatory	ADJ
dti-1319	583	4	rna	rna	NOUN
dti-1319	583	5	controls	control	VERB
dti-1319	583	6	developmental	developmental	ADJ
dti-1319	583	7	timing	timing	NOUN
dti-1319	583	8	in	in	ADP
dti-1319	583	9	caenorhabditis	caenorhabditis	ADJ
dti-1319	583	10	elegans	elegan	NOUN
dti-1319	583	11	by	by	ADP
dti-1319	583	12	blocking	block	VERB
dti-1319	583	13	lin-14	lin-14	PART
dti-1319	583	14	protein	protein	NOUN
dti-1319	583	15	synthesis	synthesis	NOUN
dti-1319	583	16	after	after	ADP
dti-1319	583	17	the	the	DET
dti-1319	583	18	initiation	initiation	NOUN
dti-1319	583	19	of	of	ADP
dti-1319	583	20	translation	translation	NOUN
dti-1319	583	21	.	.	PUNCT
dti-1319	584	1	dev	dev	PROPN
dti-1319	584	2	.	.	PUNCT
dti-1319	585	1	biol	biol	PROPN
dti-1319	585	2	.	.	PUNCT
dti-1319	585	3	,	,	PUNCT
dti-1319	585	4	216:671–80	216:671–80	NUM
dti-1319	585	5	.	.	PUNCT
dti-1319	585	6	195	195	NUM
dti-1319	585	7	delivery	delivery	NOUN
dti-1319	585	8	systems	system	NOUN
dti-1319	585	9	of	of	ADP
dti-1319	585	10	nucleic	nucleic	ADJ
dti-1319	585	11	acids	acid	NOUN
dti-1319	585	12	drugs	drug	NOUN
dti-1319	585	13	drug	drug	NOUN
dti-1319	585	14	target	target	NOUN
dti-1319	585	15	insights	insight	VERB
dti-1319	585	16	2007:2	2007:2	NUM
dti-1319	585	17	olsen	olsen	NOUN
dti-1319	585	18	,	,	PUNCT
dti-1319	585	19	t.w	t.w	PROPN
dti-1319	585	20	.	.	PROPN
dti-1319	585	21	,	,	PUNCT
dti-1319	585	22	edelhauser	edelhauser	PROPN
dti-1319	585	23	,	,	PUNCT
dti-1319	585	24	h.f	h.f	PROPN
dti-1319	585	25	.	.	PROPN
dti-1319	585	26	,	,	PUNCT
dti-1319	585	27	lim	lim	PROPN
dti-1319	585	28	,	,	PUNCT
dti-1319	585	29	j.i	j.i	PROPN
dti-1319	585	30	.	.	PROPN
dti-1319	585	31	,	,	PUNCT
dti-1319	585	32	et	et	PROPN
dti-1319	585	33	al	al	PROPN
dti-1319	585	34	.	.	PROPN
dti-1319	585	35	1995	1995	NUM
dti-1319	585	36	.	.	PUNCT
dti-1319	586	1	human	human	ADJ
dti-1319	586	2	scleral	scleral	ADJ
dti-1319	586	3	permeability	permeability	NOUN
dti-1319	586	4	.	.	PUNCT
dti-1319	587	1	invest	invest	VERB
dti-1319	587	2	ophthalmol	ophthalmol	PROPN
dti-1319	587	3	.	.	PUNCT
dti-1319	588	1	vis	vis	X
dti-1319	588	2	.	.	PUNCT
dti-1319	589	1	sci	sci	PROPN
dti-1319	589	2	.	.	PROPN
dti-1319	589	3	,	,	PUNCT
dti-1319	589	4	36:1893–903	36:1893–903	PROPN
dti-1319	589	5	.	.	PUNCT
dti-1319	589	6	olsen	olsen	PROPN
dti-1319	589	7	,	,	PUNCT
dti-1319	589	8	t.w	t.w	PROPN
dti-1319	589	9	.	.	PROPN
dti-1319	589	10	,	,	PUNCT
dti-1319	589	11	aaberg	aaberg	PROPN
dti-1319	589	12	,	,	PUNCT
dti-1319	589	13	s.y	s.y	PROPN
dti-1319	589	14	.	.	PROPN
dti-1319	589	15	,	,	PUNCT
dti-1319	589	16	geroski	geroski	PROPN
dti-1319	589	17	,	,	PUNCT
dti-1319	589	18	d.h	d.h	PROPN
dti-1319	589	19	.	.	PROPN
dti-1319	589	20	,	,	PUNCT
dti-1319	589	21	et	et	PROPN
dti-1319	589	22	al	al	PROPN
dti-1319	589	23	.	.	PROPN
dti-1319	589	24	1998	1998	NUM
dti-1319	589	25	.	.	PUNCT
dti-1319	590	1	human	human	ADJ
dti-1319	590	2	sclera	sclera	NOUN
dti-1319	590	3	:	:	PUNCT
dti-1319	590	4	thickness	thickness	NOUN
dti-1319	590	5	and	and	CCONJ
dti-1319	590	6	surface	surface	NOUN
dti-1319	590	7	area	area	NOUN
dti-1319	590	8	.	.	PUNCT
dti-1319	591	1	am	be	AUX
dti-1319	591	2	.	.	PUNCT
dti-1319	592	1	j.	j.	PROPN
dti-1319	592	2	ophthalmol	ophthalmol	PROPN
dti-1319	592	3	.	.	PUNCT
dti-1319	592	4	,	,	PUNCT
dti-1319	593	1	125:237–41	125:237–41	NUM
dti-1319	593	2	.	.	PUNCT
dti-1319	594	1	patil	patil	PROPN
dti-1319	594	2	,	,	PUNCT
dti-1319	594	3	s.d	s.d	PROPN
dti-1319	594	4	.	.	PROPN
dti-1319	594	5	,	,	PUNCT
dti-1319	594	6	rhodes	rhodes	PROPN
dti-1319	594	7	,	,	PUNCT
dti-1319	594	8	d.g	d.g	PROPN
dti-1319	594	9	.	.	PROPN
dti-1319	594	10	and	and	CCONJ
dti-1319	594	11	burgess	burgess	PROPN
dti-1319	594	12	,	,	PUNCT
dti-1319	594	13	d.j	d.j	PROPN
dti-1319	594	14	.	.	PROPN
dti-1319	594	15	2005	2005	NUM
dti-1319	594	16	.	.	PUNCT
dti-1319	595	1	dna	dna	NOUN
dti-1319	595	2	-	-	PUNCT
dti-1319	595	3	based	base	VERB
dti-1319	595	4	therapeutics	therapeutic	NOUN
dti-1319	595	5	and	and	CCONJ
dti-1319	595	6	dna	dna	PROPN
dti-1319	595	7	delivery	delivery	NOUN
dti-1319	595	8	systems	system	NOUN
dti-1319	595	9	:	:	PUNCT
dti-1319	595	10	a	a	DET
dti-1319	595	11	comprehensive	comprehensive	ADJ
dti-1319	595	12	review	review	NOUN
dti-1319	595	13	.	.	PUNCT
dti-1319	596	1	aaps	aaps	PROPN
dti-1319	596	2	j	j	PROPN
dti-1319	596	3	,	,	PUNCT
dti-1319	596	4	7	7	NUM
dti-1319	596	5	:	:	PUNCT
dti-1319	596	6	e61–77	e61–77	PROPN
dti-1319	596	7	.	.	PUNCT
dti-1319	597	1	perry	perry	PROPN
dti-1319	597	2	,	,	PUNCT
dti-1319	597	3	c.m	c.m	PROPN
dti-1319	597	4	.	.	PROPN
dti-1319	597	5	,	,	PUNCT
dti-1319	597	6	balfour	balfour	PROPN
dti-1319	597	7	,	,	PUNCT
dti-1319	597	8	j.a	j.a	PROPN
dti-1319	597	9	.	.	PROPN
dti-1319	597	10	,	,	PUNCT
dti-1319	597	11	fomivirsen	fomivirsen	PROPN
dti-1319	597	12	.	.	PUNCT
dti-1319	597	13	1999	1999	NUM
dti-1319	597	14	.	.	PUNCT
dti-1319	598	1	drugs	drug	NOUN
dti-1319	598	2	,	,	PUNCT
dti-1319	598	3	57:375–80	57:375–80	PROPN
dti-1319	598	4	.	.	PUNCT
dti-1319	598	5	rajasekaran	rajasekaran	PROPN
dti-1319	598	6	,	,	PUNCT
dti-1319	598	7	a.k	a.k	PROPN
dti-1319	598	8	.	.	PROPN
dti-1319	598	9	,	,	PUNCT
dti-1319	598	10	anilkumar	anilkumar	PROPN
dti-1319	598	11	,	,	PUNCT
dti-1319	598	12	g.	g.	PROPN
dti-1319	598	13	and	and	CCONJ
dti-1319	598	14	christiansen	christiansen	PROPN
dti-1319	598	15	,	,	PUNCT
dti-1319	598	16	j.j	j.j	PROPN
dti-1319	598	17	.	.	PROPN
dti-1319	598	18	2005	2005	NUM
dti-1319	598	19	.	.	PUNCT
dti-1319	598	20	is	be	AUX
dti-1319	598	21	prostatespecifi	prostatespecifi	PROPN
dti-1319	598	22	c	c	NOUN
dti-1319	598	23	membrane	membrane	NOUN
dti-1319	598	24	antigen	antigen	ADP
dti-1319	598	25	a	a	DET
dti-1319	598	26	multifunctional	multifunctional	ADJ
dti-1319	598	27	protein	protein	NOUN
dti-1319	598	28	?	?	PUNCT
dti-1319	599	1	am	be	AUX
dti-1319	599	2	.	.	PUNCT
dti-1319	600	1	j.	j.	PROPN
dti-1319	600	2	physiol	physiol	PROPN
dti-1319	600	3	.	.	PUNCT
dti-1319	601	1	cell	cell	NOUN
dti-1319	601	2	physiol	physiol	PROPN
dti-1319	601	3	.	.	PUNCT
dti-1319	602	1	,	,	PUNCT
dti-1319	602	2	288	288	NUM
dti-1319	602	3	:	:	PUNCT
dti-1319	602	4	c975–81	c975–81	PROPN
dti-1319	602	5	.	.	PUNCT
dti-1319	603	1	ralph	ralph	PROPN
dti-1319	603	2	,	,	PUNCT
dti-1319	603	3	g.s	g.s	PROPN
dti-1319	603	4	.	.	PROPN
dti-1319	603	5	,	,	PUNCT
dti-1319	603	6	radcliffe	radcliffe	PROPN
dti-1319	603	7	,	,	PUNCT
dti-1319	603	8	p.a	p.a	PROPN
dti-1319	603	9	.	.	PROPN
dti-1319	603	10	,	,	PUNCT
dti-1319	603	11	day	day	PROPN
dti-1319	603	12	,	,	PUNCT
dti-1319	603	13	d.m	d.m	PROPN
dti-1319	603	14	.	.	PROPN
dti-1319	603	15	,	,	PUNCT
dti-1319	603	16	et	et	PROPN
dti-1319	603	17	al	al	PROPN
dti-1319	603	18	.	.	PROPN
dti-1319	603	19	2005	2005	NUM
dti-1319	603	20	.	.	PUNCT
dti-1319	604	1	silencing	silence	VERB
dti-1319	604	2	mutant	mutant	ADJ
dti-1319	604	3	sod1	sod1	NOUN
dti-1319	604	4	using	use	VERB
dti-1319	604	5	rnai	rnai	NOUN
dti-1319	604	6	protects	protect	NOUN
dti-1319	604	7	against	against	ADP
dti-1319	604	8	neurodegeneration	neurodegeneration	NOUN
dti-1319	604	9	and	and	CCONJ
dti-1319	604	10	extends	extend	VERB
dti-1319	604	11	survival	survival	NOUN
dti-1319	604	12	in	in	ADP
dti-1319	604	13	an	an	DET
dti-1319	604	14	als	als	NOUN
dti-1319	604	15	model	model	NOUN
dti-1319	604	16	.	.	PUNCT
dti-1319	605	1	nat	nat	PROPN
dti-1319	605	2	.	.	PUNCT
dti-1319	606	1	med	med	PROPN
dti-1319	606	2	.	.	PROPN
dti-1319	606	3	,	,	PUNCT
dti-1319	607	1	11:429–33	11:429–33	PROPN
dti-1319	607	2	.	.	PUNCT
dti-1319	608	1	raoul	raoul	PROPN
dti-1319	608	2	,	,	PUNCT
dti-1319	608	3	c.	c.	PROPN
dti-1319	608	4	,	,	PUNCT
dti-1319	608	5	abbas	abbas	NOUN
dti-1319	608	6	-	-	PUNCT
dti-1319	608	7	terki	terki	NOUN
dti-1319	608	8	,	,	PUNCT
dti-1319	608	9	t.	t.	PROPN
dti-1319	608	10	,	,	PUNCT
dti-1319	608	11	bensadoun	bensadoun	PROPN
dti-1319	608	12	,	,	PUNCT
dti-1319	608	13	j.c	j.c	PROPN
dti-1319	608	14	.	.	PROPN
dti-1319	608	15	,	,	PUNCT
dti-1319	608	16	et	et	PROPN
dti-1319	608	17	al	al	PROPN
dti-1319	608	18	.	.	PROPN
dti-1319	608	19	2005	2005	NUM
dti-1319	608	20	.	.	PUNCT
dti-1319	609	1	lentiviral	lentiviral	ADJ
dti-1319	609	2	-	-	PUNCT
dti-1319	609	3	mediated	mediate	VERB
dti-1319	609	4	silencing	silencing	NOUN
dti-1319	609	5	of	of	ADP
dti-1319	609	6	sod1	sod1	NOUN
dti-1319	609	7	through	through	ADP
dti-1319	609	8	rna	rna	NOUN
dti-1319	609	9	interference	interference	NOUN
dti-1319	609	10	retards	retard	NOUN
dti-1319	609	11	disease	disease	NOUN
dti-1319	609	12	onset	onset	VERB
dti-1319	609	13	and	and	CCONJ
dti-1319	609	14	progression	progression	NOUN
dti-1319	609	15	in	in	ADP
dti-1319	609	16	a	a	DET
dti-1319	609	17	mouse	mouse	NOUN
dti-1319	609	18	model	model	NOUN
dti-1319	609	19	of	of	ADP
dti-1319	609	20	als	al	NOUN
dti-1319	609	21	.	.	PUNCT
dti-1319	610	1	nat	nat	PROPN
dti-1319	610	2	.	.	PUNCT
dti-1319	611	1	med	med	PROPN
dti-1319	611	2	.	.	PROPN
dti-1319	611	3	,	,	PUNCT
dti-1319	611	4	11:423–8	11:423–8	NUM
dti-1319	611	5	.	.	PUNCT
dti-1319	612	1	reagan	reagan	PROPN
dti-1319	612	2	-	-	PUNCT
dti-1319	612	3	shaw	shaw	PROPN
dti-1319	612	4	,	,	PUNCT
dti-1319	612	5	s.	s.	PROPN
dti-1319	612	6	and	and	CCONJ
dti-1319	612	7	ahmad	ahmad	PROPN
dti-1319	612	8	,	,	PUNCT
dti-1319	612	9	n.	n.	NOUN
dti-1319	612	10	2005	2005	NUM
dti-1319	612	11	.	.	PUNCT
dti-1319	613	1	silencing	silence	VERB
dti-1319	613	2	of	of	ADP
dti-1319	613	3	polo	polo	NOUN
dti-1319	613	4	-	-	PUNCT
dti-1319	613	5	like	like	ADJ
dti-1319	613	6	kinase	kinase	NOUN
dti-1319	613	7	(	(	PUNCT
dti-1319	613	8	plk	plk	PROPN
dti-1319	613	9	)	)	PUNCT
dti-1319	613	10	1	1	NUM
dti-1319	613	11	via	via	ADP
dti-1319	613	12	sirna	sirna	PROPN
dti-1319	613	13	causes	cause	VERB
dti-1319	613	14	induction	induction	NOUN
dti-1319	613	15	of	of	ADP
dti-1319	613	16	apoptosis	apoptosis	NOUN
dti-1319	613	17	and	and	CCONJ
dti-1319	613	18	impairment	impairment	NOUN
dti-1319	613	19	of	of	ADP
dti-1319	613	20	mitosis	mitosis	NOUN
dti-1319	613	21	machinery	machinery	NOUN
dti-1319	613	22	in	in	ADP
dti-1319	613	23	human	human	ADJ
dti-1319	613	24	prostate	prostate	NOUN
dti-1319	613	25	cancer	cancer	NOUN
dti-1319	613	26	cells	cell	NOUN
dti-1319	613	27	:	:	PUNCT
dti-1319	613	28	implications	implication	NOUN
dti-1319	613	29	for	for	ADP
dti-1319	613	30	the	the	DET
dti-1319	613	31	treatment	treatment	NOUN
dti-1319	613	32	of	of	ADP
dti-1319	613	33	prostate	prostate	NOUN
dti-1319	613	34	cancer	cancer	NOUN
dti-1319	613	35	.	.	PUNCT
dti-1319	614	1	faseb	faseb	PROPN
dti-1319	614	2	j	j	PROPN
dti-1319	614	3	,	,	PUNCT
dti-1319	614	4	19:611–3	19:611–3	NUM
dti-1319	614	5	.	.	PUNCT
dti-1319	615	1	reinhart	reinhart	PROPN
dti-1319	615	2	,	,	PUNCT
dti-1319	615	3	b.j	b.j	PROPN
dti-1319	615	4	.	.	PROPN
dti-1319	615	5	,	,	PUNCT
dti-1319	615	6	slack	slack	VERB
dti-1319	615	7	,	,	PUNCT
dti-1319	615	8	f.j	f.j	PROPN
dti-1319	615	9	.	.	PROPN
dti-1319	615	10	,	,	PUNCT
dti-1319	615	11	basson	basson	PROPN
dti-1319	615	12	,	,	PUNCT
dti-1319	615	13	m.	m.	NOUN
dti-1319	615	14	,	,	PUNCT
dti-1319	615	15	et	et	PROPN
dti-1319	615	16	al	al	PROPN
dti-1319	615	17	.	.	PROPN
dti-1319	615	18	2000	2000	NUM
dti-1319	615	19	.	.	PUNCT
dti-1319	616	1	the	the	DET
dti-1319	616	2	21	21	NUM
dti-1319	616	3	-	-	PUNCT
dti-1319	616	4	nucleotide	nucleotide	NOUN
dti-1319	616	5	let-7	let-7	PUNCT
dti-1319	616	6	rna	rna	NOUN
dti-1319	616	7	regulates	regulate	VERB
dti-1319	616	8	developmental	developmental	ADJ
dti-1319	616	9	timing	timing	NOUN
dti-1319	616	10	in	in	ADP
dti-1319	616	11	caenorhabditis	caenorhabditis	ADJ
dti-1319	616	12	elegans	elegan	NOUN
dti-1319	616	13	.	.	PUNCT
dti-1319	617	1	nature	nature	NOUN
dti-1319	617	2	,	,	PUNCT
dti-1319	617	3	403:901–6	403:901–6	NUM
dti-1319	617	4	.	.	PUNCT
dti-1319	618	1	rhie	rhie	PROPN
dti-1319	618	2	,	,	PUNCT
dti-1319	618	3	a.	a.	PROPN
dti-1319	618	4	,	,	PUNCT
dti-1319	618	5	kirby	kirby	PROPN
dti-1319	618	6	,	,	PUNCT
dti-1319	618	7	l.	l.	PROPN
dti-1319	618	8	,	,	PUNCT
dti-1319	618	9	sayer	sayer	PROPN
dti-1319	618	10	,	,	PUNCT
dti-1319	618	11	n.	n.	PROPN
dti-1319	618	12	,	,	PUNCT
dti-1319	618	13	et	et	PROPN
dti-1319	618	14	al	al	PROPN
dti-1319	618	15	.	.	PROPN
dti-1319	618	16	2003	2003	NUM
dti-1319	618	17	.	.	PUNCT
dti-1319	619	1	characterization	characterization	NOUN
dti-1319	619	2	of	of	ADP
dti-1319	619	3	2’-fl	2’-fl	PROPN
dti-1319	619	4	uororna	uororna	NOUN
dti-1319	619	5	aptamers	aptamer	NOUN
dti-1319	619	6	that	that	PRON
dti-1319	619	7	bind	bind	VERB
dti-1319	619	8	preferentially	preferentially	ADV
dti-1319	619	9	to	to	ADP
dti-1319	619	10	disease	disease	NOUN
dti-1319	619	11	-	-	PUNCT
dti-1319	619	12	associated	associate	VERB
dti-1319	619	13	conformations	conformation	NOUN
dti-1319	619	14	of	of	ADP
dti-1319	619	15	prion	prion	NOUN
dti-1319	619	16	protein	protein	NOUN
dti-1319	619	17	and	and	CCONJ
dti-1319	619	18	inhibit	inhibit	VERB
dti-1319	619	19	conversion	conversion	NOUN
dti-1319	619	20	.	.	PUNCT
dti-1319	620	1	j.	j.	PROPN
dti-1319	620	2	biol	biol	PROPN
dti-1319	620	3	.	.	PUNCT
dti-1319	621	1	chem	chem	PROPN
dti-1319	621	2	.	.	PUNCT
dti-1319	621	3	,	,	PUNCT
dti-1319	622	1	278:39697–705	278:39697–705	NUM
dti-1319	622	2	.	.	PUNCT
dti-1319	623	1	richter	richter	PROPN
dti-1319	623	2	,	,	PUNCT
dti-1319	623	3	s.	s.	PROPN
dti-1319	623	4	,	,	PUNCT
dti-1319	623	5	cao	cao	PROPN
dti-1319	623	6	,	,	PUNCT
dti-1319	623	7	h.	h.	PROPN
dti-1319	623	8	and	and	CCONJ
dti-1319	623	9	rana	rana	PROPN
dti-1319	623	10	,	,	PUNCT
dti-1319	623	11	t.m	t.m	PROPN
dti-1319	623	12	.	.	PROPN
dti-1319	623	13	2002	2002	NUM
dti-1319	623	14	.	.	PUNCT
dti-1319	624	1	specific	specific	ADJ
dti-1319	624	2	hiv-1	hiv-1	X
dti-1319	624	3	tar	tar	NOUN
dti-1319	624	4	rna	rna	NOUN
dti-1319	624	5	loop	loop	NOUN
dti-1319	624	6	sequence	sequence	NOUN
dti-1319	624	7	and	and	CCONJ
dti-1319	624	8	functional	functional	ADJ
dti-1319	624	9	groups	group	NOUN
dti-1319	624	10	are	be	AUX
dti-1319	624	11	required	require	VERB
dti-1319	624	12	for	for	ADP
dti-1319	624	13	human	human	PROPN
dti-1319	624	14	cyclin	cyclin	PROPN
dti-1319	624	15	t1	t1	PROPN
dti-1319	624	16	-	-	PUNCT
dti-1319	624	17	tat	tat	ADJ
dti-1319	624	18	-	-	PUNCT
dti-1319	624	19	tar	tar	NOUN
dti-1319	624	20	ternary	ternary	ADJ
dti-1319	624	21	complex	complex	ADJ
dti-1319	624	22	formation	formation	NOUN
dti-1319	624	23	.	.	PUNCT
dti-1319	625	1	biochemistry	biochemistry	NOUN
dti-1319	625	2	,	,	PUNCT
dti-1319	625	3	41:6391–7	41:6391–7	NUM
dti-1319	625	4	.	.	PUNCT
dti-1319	626	1	rodriguez	rodriguez	NOUN
dti-1319	626	2	-	-	PUNCT
dti-1319	626	3	lebron	lebron	PROPN
dti-1319	626	4	,	,	PUNCT
dti-1319	626	5	e.	e.	PROPN
dti-1319	626	6	and	and	CCONJ
dti-1319	626	7	paulson	paulson	PROPN
dti-1319	626	8	,	,	PUNCT
dti-1319	626	9	h.l	h.l	PROPN
dti-1319	626	10	.	.	PROPN
dti-1319	626	11	2006	2006	NUM
dti-1319	626	12	.	.	PUNCT
dti-1319	627	1	allele	allele	PROPN
dti-1319	627	2	-	-	PUNCT
dti-1319	627	3	specifi	specifi	PROPN
dti-1319	627	4	c	c	PROPN
dti-1319	627	5	rna	rna	NOUN
dti-1319	627	6	interference	interference	NOUN
dti-1319	627	7	for	for	ADP
dti-1319	627	8	neurological	neurological	ADJ
dti-1319	627	9	disease	disease	NOUN
dti-1319	627	10	.	.	PUNCT
dti-1319	628	1	gene	gene	NOUN
dti-1319	628	2	.	.	PUNCT
dti-1319	629	1	ther	ther	PROPN
dti-1319	629	2	.	.	PUNCT
dti-1319	629	3	,	,	PUNCT
dti-1319	630	1	13:576–81	13:576–81	PROPN
dti-1319	630	2	.	.	PUNCT
dti-1319	631	1	rosenblum	rosenblum	PROPN
dti-1319	631	2	,	,	PUNCT
dti-1319	631	3	m.g	m.g	PROPN
dti-1319	631	4	.	.	PROPN
dti-1319	631	5	,	,	PUNCT
dti-1319	631	6	cheung	cheung	PROPN
dti-1319	631	7	,	,	PUNCT
dti-1319	631	8	l.h	l.h	PROPN
dti-1319	631	9	.	.	PROPN
dti-1319	631	10	,	,	PUNCT
dti-1319	631	11	liu	liu	PROPN
dti-1319	631	12	,	,	PUNCT
dti-1319	631	13	y.	y.	PROPN
dti-1319	631	14	,	,	PUNCT
dti-1319	631	15	et	et	PROPN
dti-1319	631	16	al	al	PROPN
dti-1319	631	17	.	.	PROPN
dti-1319	631	18	2003	2003	NUM
dti-1319	631	19	.	.	PUNCT
dti-1319	632	1	design	design	NOUN
dti-1319	632	2	,	,	PUNCT
dti-1319	632	3	expression	expression	NOUN
dti-1319	632	4	,	,	PUNCT
dti-1319	632	5	purifi	purifi	ADJ
dti-1319	632	6	cation	cation	NOUN
dti-1319	632	7	,	,	PUNCT
dti-1319	632	8	and	and	CCONJ
dti-1319	632	9	characterization	characterization	NOUN
dti-1319	632	10	,	,	PUNCT
dti-1319	632	11	in	in	ADP
dti-1319	632	12	vitro	vitro	X
dti-1319	632	13	and	and	CCONJ
dti-1319	632	14	in	in	ADP
dti-1319	632	15	vivo	vivo	NOUN
dti-1319	632	16	,	,	PUNCT
dti-1319	632	17	of	of	ADP
dti-1319	632	18	an	an	DET
dti-1319	632	19	antimelanoma	antimelanoma	ADJ
dti-1319	632	20	single	single	ADJ
dti-1319	632	21	-	-	PUNCT
dti-1319	632	22	chain	chain	NOUN
dti-1319	632	23	fv	fv	NOUN
dti-1319	632	24	antibody	antibody	NOUN
dti-1319	632	25	fused	fuse	VERB
dti-1319	632	26	to	to	ADP
dti-1319	632	27	the	the	DET
dti-1319	632	28	toxin	toxin	NOUN
dti-1319	632	29	gelonin	gelonin	NOUN
dti-1319	632	30	.	.	PUNCT
dti-1319	633	1	cancer	cancer	NOUN
dti-1319	633	2	res	re	NOUN
dti-1319	633	3	.	.	PROPN
dti-1319	633	4	,	,	PUNCT
dti-1319	633	5	63:3995–4002	63:3995–4002	PROPN
dti-1319	633	6	.	.	PUNCT
dti-1319	633	7	rosenblum	rosenblum	PROPN
dti-1319	633	8	,	,	PUNCT
dti-1319	633	9	m.g	m.g	PROPN
dti-1319	633	10	.	.	PROPN
dti-1319	633	11	,	,	PUNCT
dti-1319	633	12	marks	marks	PROPN
dti-1319	633	13	,	,	PUNCT
dti-1319	633	14	j.w	j.w	PROPN
dti-1319	633	15	.	.	PROPN
dti-1319	633	16	and	and	CCONJ
dti-1319	633	17	cheung	cheung	PROPN
dti-1319	633	18	,	,	PUNCT
dti-1319	633	19	l.h	l.h	PROPN
dti-1319	633	20	.	.	PROPN
dti-1319	633	21	1999	1999	NUM
dti-1319	633	22	.	.	PUNCT
dti-1319	634	1	comparative	comparative	ADJ
dti-1319	634	2	cytotoxicity	cytotoxicity	NOUN
dti-1319	634	3	and	and	CCONJ
dti-1319	634	4	pharmacokinetics	pharmacokinetic	NOUN
dti-1319	634	5	of	of	ADP
dti-1319	634	6	antimelanoma	antimelanoma	NOUN
dti-1319	634	7	immunotoxins	immunotoxin	NOUN
dti-1319	634	8	containing	contain	VERB
dti-1319	634	9	either	either	CCONJ
dti-1319	634	10	natural	natural	ADJ
dti-1319	634	11	or	or	CCONJ
dti-1319	634	12	recombinant	recombinant	ADJ
dti-1319	634	13	gelonin	gelonin	NOUN
dti-1319	634	14	.	.	PUNCT
dti-1319	635	1	cancer	cancer	NOUN
dti-1319	635	2	chemother	chemother	PROPN
dti-1319	635	3	.	.	PUNCT
dti-1319	636	1	pharmacol	pharmacol	PROPN
dti-1319	636	2	.	.	PROPN
dti-1319	636	3	,	,	PUNCT
dti-1319	636	4	44:343–8	44:343–8	NUM
dti-1319	636	5	.	.	PUNCT
dti-1319	637	1	rusconi	rusconi	PROPN
dti-1319	637	2	,	,	PUNCT
dti-1319	637	3	c.p	c.p	PROPN
dti-1319	637	4	.	.	PROPN
dti-1319	637	5	,	,	PUNCT
dti-1319	637	6	roberts	roberts	PROPN
dti-1319	637	7	,	,	PUNCT
dti-1319	637	8	j.d	j.d	PROPN
dti-1319	637	9	.	.	PROPN
dti-1319	637	10	,	,	PUNCT
dti-1319	637	11	nimjee	nimjee	PROPN
dti-1319	637	12	,	,	PUNCT
dti-1319	637	13	s.m	s.m	PROPN
dti-1319	637	14	.	.	PROPN
dti-1319	637	15	,	,	PUNCT
dti-1319	637	16	et	et	PROPN
dti-1319	637	17	al	al	PROPN
dti-1319	637	18	.	.	PROPN
dti-1319	637	19	2004	2004	NUM
dti-1319	637	20	.	.	PUNCT
dti-1319	638	1	antidote	antidote	NOUN
dti-1319	638	2	-	-	PUNCT
dti-1319	638	3	mediated	mediate	VERB
dti-1319	638	4	control	control	NOUN
dti-1319	638	5	of	of	ADP
dti-1319	638	6	an	an	DET
dti-1319	638	7	anticoagulant	anticoagulant	ADJ
dti-1319	638	8	aptamer	aptamer	NOUN
dti-1319	638	9	in	in	ADP
dti-1319	638	10	vivo	vivo	NOUN
dti-1319	638	11	.	.	PUNCT
dti-1319	639	1	nat	nat	PROPN
dti-1319	639	2	.	.	PUNCT
dti-1319	640	1	biotechnol	biotechnol	PROPN
dti-1319	640	2	.	.	PUNCT
dti-1319	640	3	,	,	PUNCT
dti-1319	640	4	22:1423–8	22:1423–8	NUM
dti-1319	640	5	.	.	PUNCT
dti-1319	641	1	sa	sa	NOUN
dti-1319	641	2	,	,	PUNCT
dti-1319	641	3	d.w.y	d.w.y	NOUN
dti-1319	641	4	.	.	PUNCT
dti-1319	641	5	2004	2004	NUM
dti-1319	641	6	.	.	PUNCT
dti-1319	642	1	therapeutic	therapeutic	ADJ
dti-1319	642	2	potential	potential	NOUN
dti-1319	642	3	of	of	ADP
dti-1319	642	4	rna	rna	NOUN
dti-1319	642	5	interference	interference	NOUN
dti-1319	642	6	for	for	ADP
dti-1319	642	7	neurological	neurological	ADJ
dti-1319	642	8	disorders	disorder	NOUN
dti-1319	642	9	.	.	PUNCT
dti-1319	643	1	life	life	NOUN
dti-1319	643	2	sci	sci	PROPN
dti-1319	643	3	.	.	PROPN
dti-1319	643	4	,	,	PUNCT
dti-1319	643	5	79:1773–80	79:1773–80	PROPN
dti-1319	643	6	.	.	PUNCT
dti-1319	643	7	scherr	scherr	PROPN
dti-1319	643	8	,	,	PUNCT
dti-1319	643	9	m.	m.	NOUN
dti-1319	643	10	,	,	PUNCT
dti-1319	643	11	morgan	morgan	PROPN
dti-1319	643	12	,	,	PUNCT
dti-1319	643	13	m.a	m.a	PROPN
dti-1319	643	14	.	.	PROPN
dti-1319	643	15	and	and	CCONJ
dti-1319	643	16	eder	eder	NOUN
dti-1319	643	17	,	,	PUNCT
dti-1319	643	18	m.	m.	NOUN
dti-1319	643	19	2003	2003	NUM
dti-1319	643	20	.	.	PUNCT
dti-1319	644	1	gene	gene	NOUN
dti-1319	644	2	silencing	silence	VERB
dti-1319	644	3	mediated	mediate	VERB
dti-1319	644	4	by	by	ADP
dti-1319	644	5	small	small	ADJ
dti-1319	644	6	interfering	interfere	VERB
dti-1319	644	7	rnas	rna	NOUN
dti-1319	644	8	in	in	ADP
dti-1319	644	9	mammalian	mammalian	ADJ
dti-1319	644	10	cells	cell	NOUN
dti-1319	644	11	.	.	PUNCT
dti-1319	645	1	curr	curr	AUX
dti-1319	645	2	.	.	PUNCT
dti-1319	645	3	med	med	PROPN
dti-1319	645	4	.	.	PROPN
dti-1319	645	5	chem	chem	PROPN
dti-1319	645	6	.	.	PUNCT
dti-1319	645	7	,	,	PUNCT
dti-1319	645	8	10:245–56	10:245–56	NUM
dti-1319	645	9	.	.	PUNCT
dti-1319	646	1	seggerson	seggerson	PROPN
dti-1319	646	2	,	,	PUNCT
dti-1319	646	3	k.	k.	PROPN
dti-1319	646	4	,	,	PUNCT
dti-1319	646	5	tang	tang	PROPN
dti-1319	646	6	,	,	PUNCT
dti-1319	646	7	l.	l.	PROPN
dti-1319	646	8	and	and	CCONJ
dti-1319	646	9	moss	moss	NOUN
dti-1319	646	10	,	,	PUNCT
dti-1319	646	11	e.g.	e.g.	ADV
dti-1319	646	12	2002	2002	NUM
dti-1319	646	13	.	.	PUNCT
dti-1319	647	1	two	two	NUM
dti-1319	647	2	genetic	genetic	ADJ
dti-1319	647	3	circuits	circuit	NOUN
dti-1319	647	4	repress	repress	VERB
dti-1319	647	5	the	the	DET
dti-1319	647	6	caenorhabditis	caenorhabditis	NOUN
dti-1319	647	7	elegans	elegan	NOUN
dti-1319	647	8	heterochronic	heterochronic	ADJ
dti-1319	647	9	gene	gene	NOUN
dti-1319	647	10	lin-28	lin-28	PROPN
dti-1319	647	11	after	after	ADP
dti-1319	647	12	translation	translation	NOUN
dti-1319	647	13	initiation	initiation	NOUN
dti-1319	647	14	.	.	PUNCT
dti-1319	648	1	dev	dev	PROPN
dti-1319	648	2	.	.	PUNCT
dti-1319	649	1	biol	biol	PROPN
dti-1319	649	2	.	.	PUNCT
dti-1319	649	3	,	,	PUNCT
dti-1319	649	4	243:215−25	243:215−25	PROPN
dti-1319	649	5	.	.	PUNCT
dti-1319	650	1	shi	shi	PROPN
dti-1319	650	2	,	,	PUNCT
dti-1319	650	3	h.	h.	PROPN
dti-1319	650	4	,	,	PUNCT
dti-1319	650	5	fan	fan	PROPN
dti-1319	650	6	,	,	PUNCT
dti-1319	650	7	x.	x.	PROPN
dti-1319	650	8	,	,	PUNCT
dti-1319	650	9	sevilimedu	sevilimedu	ADV
dti-1319	650	10	,	,	PUNCT
dti-1319	650	11	a.	a.	NOUN
dti-1319	650	12	and	and	CCONJ
dti-1319	650	13	lis	lis	PROPN
dti-1319	650	14	,	,	PUNCT
dti-1319	650	15	j.t	j.t	PROPN
dti-1319	650	16	.	.	PROPN
dti-1319	650	17	2007	2007	NUM
dti-1319	650	18	.	.	PUNCT
dti-1319	651	1	rna	rna	NOUN
dti-1319	651	2	aptamers	aptamer	NOUN
dti-1319	651	3	directed	direct	VERB
dti-1319	651	4	to	to	PART
dti-1319	651	5	discrete	discrete	VERB
dti-1319	651	6	functional	functional	ADJ
dti-1319	651	7	sites	site	NOUN
dti-1319	651	8	on	on	ADP
dti-1319	651	9	a	a	DET
dti-1319	651	10	single	single	ADJ
dti-1319	651	11	protein	protein	NOUN
dti-1319	651	12	structural	structural	ADJ
dti-1319	651	13	domain	domain	NOUN
dti-1319	651	14	.	.	PUNCT
dti-1319	652	1	proc	proc	PROPN
dti-1319	652	2	.	.	PUNCT
dti-1319	653	1	natl	natl	PROPN
dti-1319	653	2	.	.	PUNCT
dti-1319	654	1	acad	acad	PROPN
dti-1319	654	2	.	.	PUNCT
dti-1319	655	1	sci	sci	PROPN
dti-1319	655	2	.	.	PUNCT
dti-1319	655	3	u.s.a	u.s.a	PROPN
dti-1319	655	4	.	.	PUNCT
dti-1319	655	5	104:3742–6	104:3742–6	PROPN
dti-1319	655	6	.	.	PUNCT
dti-1319	656	1	shi	shi	PROPN
dti-1319	656	2	,	,	PUNCT
dti-1319	656	3	h.	h.	PROPN
dti-1319	656	4	,	,	PUNCT
dti-1319	656	5	hoffman	hoffman	PROPN
dti-1319	656	6	,	,	PUNCT
dti-1319	656	7	b.e	b.e	PROPN
dti-1319	656	8	.	.	PROPN
dti-1319	656	9	and	and	CCONJ
dti-1319	656	10	lis	lis	PROPN
dti-1319	656	11	,	,	PUNCT
dti-1319	656	12	j.t	j.t	PROPN
dti-1319	656	13	.	.	PROPN
dti-1319	656	14	1999	1999	NUM
dti-1319	656	15	.	.	PUNCT
dti-1319	657	1	rna	rna	NOUN
dti-1319	657	2	aptamers	aptamer	NOUN
dti-1319	657	3	as	as	ADP
dti-1319	657	4	effective	effective	ADJ
dti-1319	657	5	protein	protein	NOUN
dti-1319	657	6	antagonists	antagonist	NOUN
dti-1319	657	7	in	in	ADP
dti-1319	657	8	a	a	DET
dti-1319	657	9	multicellular	multicellular	ADJ
dti-1319	657	10	organism	organism	NOUN
dti-1319	657	11	.	.	PUNCT
dti-1319	658	1	proc	proc	NOUN
dti-1319	658	2	.	.	PUNCT
dti-1319	659	1	natl	natl	PROPN
dti-1319	659	2	.	.	PUNCT
dti-1319	660	1	acad	acad	PROPN
dti-1319	660	2	.	.	PUNCT
dti-1319	661	1	sci	sci	PROPN
dti-1319	661	2	.	.	PUNCT
dti-1319	661	3	u.s.a	u.s.a	PROPN
dti-1319	661	4	.	.	PROPN
dti-1319	661	5	,	,	PUNCT
dti-1319	661	6	96:10033–8	96:10033–8	NUM
dti-1319	661	7	.	.	PUNCT
dti-1319	662	1	singer	singer	NOUN
dti-1319	662	2	,	,	PUNCT
dti-1319	662	3	o.	o.	PROPN
dti-1319	662	4	,	,	PUNCT
dti-1319	662	5	marr	marr	PROPN
dti-1319	662	6	,	,	PUNCT
dti-1319	662	7	r.a	r.a	PROPN
dti-1319	662	8	.	.	PROPN
dti-1319	662	9	,	,	PUNCT
dti-1319	662	10	rockenstein	rockenstein	PROPN
dti-1319	662	11	,	,	PUNCT
dti-1319	662	12	e.	e.	PROPN
dti-1319	662	13	,	,	PUNCT
dti-1319	662	14	et	et	PROPN
dti-1319	662	15	al	al	PROPN
dti-1319	662	16	.	.	PROPN
dti-1319	662	17	2005	2005	NUM
dti-1319	662	18	.	.	PUNCT
dti-1319	663	1	targeting	target	VERB
dti-1319	663	2	bace1	bace1	NOUN
dti-1319	663	3	with	with	ADP
dti-1319	663	4	sirnas	sirna	NOUN
dti-1319	663	5	ameliorates	ameliorate	VERB
dti-1319	663	6	alzheimer	alzheimer	PROPN
dti-1319	663	7	disease	disease	PROPN
dti-1319	663	8	neuropathology	neuropathology	NOUN
dti-1319	663	9	in	in	ADP
dti-1319	663	10	a	a	DET
dti-1319	663	11	transgenic	transgenic	NOUN
dti-1319	663	12	model	model	NOUN
dti-1319	663	13	.	.	PUNCT
dti-1319	664	1	nat	nat	PROPN
dti-1319	664	2	.	.	PUNCT
dti-1319	665	1	neurosci	neurosci	PROPN
dti-1319	665	2	.	.	PUNCT
dti-1319	665	3	,	,	PUNCT
dti-1319	665	4	8:1343–9	8:1343–9	PROPN
dti-1319	665	5	.	.	PUNCT
dti-1319	666	1	song	song	PROPN
dti-1319	666	2	,	,	PUNCT
dti-1319	666	3	e.	e.	PROPN
dti-1319	666	4	,	,	PUNCT
dti-1319	666	5	lee	lee	PROPN
dti-1319	666	6	,	,	PUNCT
dti-1319	666	7	s.k	s.k	PROPN
dti-1319	666	8	.	.	PROPN
dti-1319	666	9	,	,	PUNCT
dti-1319	666	10	wang	wang	PROPN
dti-1319	666	11	,	,	PUNCT
dti-1319	666	12	j.	j.	PROPN
dti-1319	666	13	,	,	PUNCT
dti-1319	666	14	et	et	PROPN
dti-1319	666	15	al	al	PROPN
dti-1319	666	16	.	.	PROPN
dti-1319	666	17	2003	2003	NUM
dti-1319	666	18	.	.	PUNCT
dti-1319	667	1	rna	rna	NOUN
dti-1319	667	2	interference	interference	NOUN
dti-1319	667	3	targeting	target	VERB
dti-1319	667	4	fas	fas	NOUN
dti-1319	667	5	protects	protect	VERB
dti-1319	667	6	mice	mouse	NOUN
dti-1319	667	7	from	from	ADP
dti-1319	667	8	fulminant	fulminant	ADJ
dti-1319	667	9	hepatitis	hepatitis	NOUN
dti-1319	667	10	.	.	PUNCT
dti-1319	668	1	nat	nat	PROPN
dti-1319	668	2	.	.	PUNCT
dti-1319	669	1	med	med	PROPN
dti-1319	669	2	.	.	PROPN
dti-1319	669	3	,	,	PUNCT
dti-1319	670	1	9:347–51	9:347–51	X
dti-1319	670	2	.	.	PUNCT
dti-1319	670	3	song	song	PROPN
dti-1319	670	4	,	,	PUNCT
dti-1319	670	5	e.	e.	PROPN
dti-1319	670	6	,	,	PUNCT
dti-1319	670	7	zhu	zhu	PROPN
dti-1319	670	8	,	,	PUNCT
dti-1319	670	9	p.	p.	PROPN
dti-1319	670	10	,	,	PUNCT
dti-1319	670	11	lee	lee	PROPN
dti-1319	670	12	,	,	PUNCT
dti-1319	670	13	s.k	s.k	PROPN
dti-1319	670	14	.	.	PROPN
dti-1319	670	15	,	,	PUNCT
dti-1319	670	16	et	et	PROPN
dti-1319	670	17	al	al	PROPN
dti-1319	670	18	.	.	PROPN
dti-1319	670	19	2005	2005	NUM
dti-1319	670	20	.	.	PUNCT
dti-1319	671	1	antibody	antibody	NOUN
dti-1319	671	2	mediated	mediate	VERB
dti-1319	671	3	in	in	ADP
dti-1319	671	4	vivo	vivo	ADJ
dti-1319	671	5	delivery	delivery	NOUN
dti-1319	671	6	of	of	ADP
dti-1319	671	7	small	small	ADJ
dti-1319	671	8	interfering	interfere	VERB
dti-1319	671	9	rnas	rna	NOUN
dti-1319	671	10	via	via	ADP
dti-1319	671	11	cell	cell	NOUN
dti-1319	671	12	-	-	PUNCT
dti-1319	671	13	surface	surface	NOUN
dti-1319	671	14	receptors	receptor	NOUN
dti-1319	671	15	.	.	PUNCT
dti-1319	672	1	nat	nat	NOUN
dti-1319	672	2	.	.	PUNCT
dti-1319	673	1	biotechnol	biotechnol	PROPN
dti-1319	673	2	.	.	PUNCT
dti-1319	673	3	,	,	PUNCT
dti-1319	674	1	3:709–17	3:709–17	PROPN
dti-1319	674	2	.	.	PUNCT
dti-1319	674	3	soutschek	soutschek	PROPN
dti-1319	674	4	,	,	PUNCT
dti-1319	674	5	j.	j.	PROPN
dti-1319	674	6	,	,	PUNCT
dti-1319	674	7	akinc	akinc	PROPN
dti-1319	674	8	,	,	PUNCT
dti-1319	674	9	a.	a.	NOUN
dti-1319	674	10	,	,	PUNCT
dti-1319	674	11	bramlage	bramlage	NOUN
dti-1319	674	12	,	,	PUNCT
dti-1319	674	13	b.	b.	PROPN
dti-1319	674	14	,	,	PUNCT
dti-1319	674	15	et	et	PROPN
dti-1319	674	16	al	al	PROPN
dti-1319	674	17	.	.	PROPN
dti-1319	674	18	2004	2004	NUM
dti-1319	674	19	.	.	PUNCT
dti-1319	675	1	therapeutic	therapeutic	ADJ
dti-1319	675	2	silencing	silencing	NOUN
dti-1319	675	3	of	of	ADP
dti-1319	675	4	an	an	DET
dti-1319	675	5	endogenous	endogenous	ADJ
dti-1319	675	6	gene	gene	NOUN
dti-1319	675	7	by	by	ADP
dti-1319	675	8	systemic	systemic	ADJ
dti-1319	675	9	administration	administration	NOUN
dti-1319	675	10	of	of	ADP
dti-1319	675	11	modifi	modifi	PROPN
dti-1319	675	12	ed	ed	PROPN
dti-1319	675	13	sirnas	sirnas	PROPN
dti-1319	675	14	.	.	PUNCT
dti-1319	676	1	nature	nature	NOUN
dti-1319	676	2	,	,	PUNCT
dti-1319	676	3	11;432:173–8	11;432:173–8	NUM
dti-1319	676	4	.	.	PUNCT
dti-1319	677	1	stull	stull	PROPN
dti-1319	677	2	,	,	PUNCT
dti-1319	677	3	r.a	r.a	PROPN
dti-1319	677	4	.	.	PROPN
dti-1319	677	5	,	,	PUNCT
dti-1319	677	6	szoka	szoka	VERB
dti-1319	677	7	fc	fc	PROPN
dti-1319	677	8	jr	jr	PROPN
dti-1319	677	9	.	.	PROPN
dti-1319	677	10	1995	1995	NUM
dti-1319	677	11	.	.	PUNCT
dti-1319	678	1	antigene	antigene	PROPN
dti-1319	678	2	,	,	PUNCT
dti-1319	678	3	ribozyme	ribozyme	NOUN
dti-1319	678	4	and	and	CCONJ
dti-1319	678	5	aptamer	aptamer	NOUN
dti-1319	678	6	nucleic	nucleic	ADJ
dti-1319	678	7	acid	acid	NOUN
dti-1319	678	8	drugs	drug	NOUN
dti-1319	678	9	:	:	PUNCT
dti-1319	678	10	progress	progress	NOUN
dti-1319	678	11	and	and	CCONJ
dti-1319	678	12	prospects	prospect	NOUN
dti-1319	678	13	.	.	PUNCT
dti-1319	679	1	pharm	pharm	NOUN
dti-1319	679	2	.	.	PUNCT
dti-1319	680	1	res	re	NOUN
dti-1319	680	2	.	.	PROPN
dti-1319	680	3	,	,	PUNCT
dti-1319	681	1	12:465–83	12:465–83	PROPN
dti-1319	681	2	.	.	PUNCT
dti-1319	681	3	sverdlov	sverdlov	PROPN
dti-1319	681	4	,	,	PUNCT
dti-1319	681	5	e.d	e.d	PROPN
dti-1319	681	6	.	.	PROPN
dti-1319	681	7	2001	2001	NUM
dti-1319	681	8	.	.	PUNCT
dti-1319	682	1	rna	rna	NOUN
dti-1319	682	2	interferencea	interferencea	NOUN
dti-1319	682	3	novel	novel	NOUN
dti-1319	682	4	mechanism	mechanism	NOUN
dti-1319	682	5	of	of	ADP
dti-1319	682	6	regulation	regulation	NOUN
dti-1319	682	7	of	of	ADP
dti-1319	682	8	gene	gene	NOUN
dti-1319	682	9	expression	expression	NOUN
dti-1319	682	10	and	and	CCONJ
dti-1319	682	11	a	a	DET
dti-1319	682	12	novel	novel	ADJ
dti-1319	682	13	method	method	NOUN
dti-1319	682	14	of	of	ADP
dti-1319	682	15	study	study	NOUN
dti-1319	682	16	of	of	ADP
dti-1319	682	17	their	their	PRON
dti-1319	682	18	functions	function	NOUN
dti-1319	682	19	.	.	PUNCT
dti-1319	683	1	russian	russian	ADJ
dti-1319	683	2	journal	journal	PROPN
dti-1319	683	3	of	of	ADP
dti-1319	683	4	bioorganic	bioorganic	ADJ
dti-1319	683	5	chemistry	chemistry	NOUN
dti-1319	683	6	,	,	PUNCT
dti-1319	683	7	27:209–12	27:209–12	NOUN
dti-1319	683	8	.	.	PUNCT
dti-1319	684	1	takai	takai	PROPN
dti-1319	684	2	,	,	PUNCT
dti-1319	684	3	n.	n.	PROPN
dti-1319	684	4	,	,	PUNCT
dti-1319	684	5	ueda	ueda	PROPN
dti-1319	684	6	,	,	PUNCT
dti-1319	684	7	t.	t.	PROPN
dti-1319	684	8	,	,	PUNCT
dti-1319	684	9	nishida	nishida	PROPN
dti-1319	684	10	,	,	PUNCT
dti-1319	684	11	m.	m.	NOUN
dti-1319	684	12	,	,	PUNCT
dti-1319	684	13	et	et	PROPN
dti-1319	684	14	al	al	PROPN
dti-1319	684	15	.	.	PROPN
dti-1319	684	16	2004	2004	NUM
dti-1319	684	17	.	.	PUNCT
dti-1319	685	1	the	the	DET
dti-1319	685	2	relationship	relationship	NOUN
dti-1319	685	3	between	between	ADP
dti-1319	685	4	oncogene	oncogene	NOUN
dti-1319	685	5	expression	expression	NOUN
dti-1319	685	6	and	and	CCONJ
dti-1319	685	7	clinical	clinical	ADJ
dti-1319	685	8	outcome	outcome	NOUN
dti-1319	685	9	in	in	ADP
dti-1319	685	10	endometrial	endometrial	ADJ
dti-1319	685	11	carcinoma	carcinoma	NOUN
dti-1319	685	12	.	.	PUNCT
dti-1319	686	1	curr	curr	PROPN
dti-1319	686	2	.	.	PUNCT
dti-1319	686	3	cancer	cancer	NOUN
dti-1319	686	4	drug	drug	NOUN
dti-1319	686	5	targets	target	NOUN
dti-1319	686	6	,	,	PUNCT
dti-1319	686	7	4:511–20	4:511–20	PROPN
dti-1319	686	8	.	.	PUNCT
dti-1319	686	9	takei	takei	PROPN
dti-1319	686	10	,	,	PUNCT
dti-1319	686	11	y.	y.	PROPN
dti-1319	686	12	,	,	PUNCT
dti-1319	686	13	kadomatsu	kadomatsu	NOUN
dti-1319	686	14	,	,	PUNCT
dti-1319	686	15	k.	k.	PROPN
dti-1319	686	16	,	,	PUNCT
dti-1319	686	17	yuzawa	yuzawa	PROPN
dti-1319	686	18	,	,	PUNCT
dti-1319	686	19	y.	y.	PROPN
dti-1319	686	20	,	,	PUNCT
dti-1319	686	21	et	et	PROPN
dti-1319	686	22	al	al	PROPN
dti-1319	686	23	.	.	PROPN
dti-1319	686	24	2004	2004	NUM
dti-1319	686	25	.	.	PUNCT
dti-1319	687	1	a	a	DET
dti-1319	687	2	small	small	ADJ
dti-1319	687	3	interfering	interfere	VERB
dti-1319	687	4	rna	rna	NOUN
dti-1319	687	5	targeting	target	VERB
dti-1319	687	6	vascular	vascular	ADJ
dti-1319	687	7	endothelial	endothelial	ADJ
dti-1319	687	8	growth	growth	NOUN
dti-1319	687	9	factor	factor	NOUN
dti-1319	687	10	as	as	ADP
dti-1319	687	11	cancer	cancer	NOUN
dti-1319	687	12	therapeutics	therapeutic	NOUN
dti-1319	687	13	.	.	PUNCT
dti-1319	688	1	cancer	cancer	NOUN
dti-1319	688	2	res	re	NOUN
dti-1319	688	3	.	.	PROPN
dti-1319	688	4	,	,	PUNCT
dti-1319	688	5	64:3365–70	64:3365–70	NUM
dti-1319	688	6	.	.	PUNCT
dti-1319	688	7	tang	tang	PROPN
dti-1319	688	8	,	,	PUNCT
dti-1319	688	9	j.	j.	PROPN
dti-1319	688	10	,	,	PUNCT
dti-1319	688	11	breaker	breaker	PROPN
dti-1319	688	12	,	,	PUNCT
dti-1319	688	13	r.r	r.r	PROPN
dti-1319	688	14	.	.	PROPN
dti-1319	688	15	1997	1997	NUM
dti-1319	688	16	.	.	PUNCT
dti-1319	689	1	rational	rational	ADJ
dti-1319	689	2	design	design	NOUN
dti-1319	689	3	of	of	ADP
dti-1319	689	4	allosteric	allosteric	ADJ
dti-1319	689	5	ribozymes	ribozyme	NOUN
dti-1319	689	6	.	.	PUNCT
dti-1319	690	1	chem	chem	NOUN
dti-1319	690	2	.	.	PUNCT
dti-1319	691	1	biol	biol	PROPN
dti-1319	691	2	.	.	PUNCT
dti-1319	691	3	,	,	PUNCT
dti-1319	691	4	4:453–9	4:453–9	NUM
dti-1319	692	1	.	.	PUNCT
dti-1319	692	2	theis	theis	PROPN
dti-1319	692	3	,	,	PUNCT
dti-1319	692	4	m.g	m.g	PROPN
dti-1319	692	5	.	.	PROPN
dti-1319	692	6	,	,	PUNCT
dti-1319	692	7	knorre	knorre	PROPN
dti-1319	692	8	,	,	PUNCT
dti-1319	692	9	a.	a.	PROPN
dti-1319	692	10	,	,	PUNCT
dti-1319	692	11	kellersch	kellersch	PROPN
dti-1319	692	12	,	,	PUNCT
dti-1319	692	13	b.	b.	PROPN
dti-1319	692	14	,	,	PUNCT
dti-1319	692	15	et	et	PROPN
dti-1319	692	16	al	al	PROPN
dti-1319	692	17	.	.	PROPN
dti-1319	692	18	2004	2004	NUM
dti-1319	692	19	.	.	PUNCT
dti-1319	693	1	discriminatory	discriminatory	ADJ
dti-1319	693	2	aptamer	aptamer	NOUN
dti-1319	693	3	reveals	reveal	VERB
dti-1319	693	4	serum	serum	NOUN
dti-1319	693	5	response	response	NOUN
dti-1319	693	6	element	element	NOUN
dti-1319	693	7	transcription	transcription	NOUN
dti-1319	693	8	regulated	regulate	VERB
dti-1319	693	9	by	by	ADP
dti-1319	693	10	cytohesin-2	cytohesin-2	X
dti-1319	693	11	.	.	PUNCT
dti-1319	693	12	proc	proc	PROPN
dti-1319	693	13	.	.	PUNCT
dti-1319	694	1	natl	natl	PROPN
dti-1319	694	2	.	.	PUNCT
dti-1319	695	1	acad	acad	PROPN
dti-1319	695	2	.	.	PUNCT
dti-1319	696	1	sci	sci	PROPN
dti-1319	696	2	.	.	PUNCT
dti-1319	696	3	u.s.a	u.s.a	PROPN
dti-1319	696	4	.	.	PROPN
dti-1319	696	5	,	,	PUNCT
dti-1319	696	6	101:11221–6	101:11221–6	NUM
dti-1319	696	7	.	.	PUNCT
dti-1319	697	1	toulmé	toulmé	PROPN
dti-1319	697	2	jj	jj	PROPN
dti-1319	697	3	,	,	PUNCT
dti-1319	697	4	darfeuille	darfeuille	PROPN
dti-1319	697	5	,	,	PUNCT
dti-1319	697	6	f.	f.	PROPN
dti-1319	697	7	,	,	PUNCT
dti-1319	697	8	kolb	kolb	PROPN
dti-1319	697	9	,	,	PUNCT
dti-1319	697	10	g.	g.	PROPN
dti-1319	697	11	,	,	PUNCT
dti-1319	697	12	et	et	PROPN
dti-1319	697	13	al	al	PROPN
dti-1319	697	14	.	.	PROPN
dti-1319	697	15	2003	2003	NUM
dti-1319	697	16	.	.	PUNCT
dti-1319	698	1	modulating	modulate	VERB
dti-1319	698	2	viral	viral	ADJ
dti-1319	698	3	gene	gene	NOUN
dti-1319	698	4	expression	expression	NOUN
dti-1319	698	5	by	by	ADP
dti-1319	698	6	aptamers	aptamer	NOUN
dti-1319	698	7	to	to	ADP
dti-1319	698	8	rna	rna	NOUN
dti-1319	698	9	structures	structure	NOUN
dti-1319	698	10	.	.	PUNCT
dti-1319	699	1	biol	biol	PROPN
dti-1319	699	2	.	.	PUNCT
dti-1319	700	1	cell	cell	NOUN
dti-1319	700	2	,	,	PUNCT
dti-1319	700	3	95	95	NUM
dti-1319	700	4	:	:	PUNCT
dti-1319	700	5	229–38	229–38	NOUN
dti-1319	700	6	.	.	PUNCT
dti-1319	701	1	toulmé	toulmé	PROPN
dti-1319	701	2	jj	jj	PROPN
dti-1319	701	3	,	,	PUNCT
dti-1319	701	4	di	di	X
dti-1319	701	5	primo	primo	PROPN
dti-1319	701	6	,	,	PUNCT
dti-1319	701	7	c.	c.	PROPN
dti-1319	701	8	,	,	PUNCT
dti-1319	701	9	moreau	moreau	PROPN
dti-1319	701	10	,	,	PUNCT
dti-1319	701	11	s.	s.	PROPN
dti-1319	701	12	2001	2001	NUM
dti-1319	701	13	.	.	PUNCT
dti-1319	702	1	modulation	modulation	NOUN
dti-1319	702	2	of	of	ADP
dti-1319	702	3	rna	rna	NOUN
dti-1319	702	4	function	function	NOUN
dti-1319	702	5	by	by	ADP
dti-1319	702	6	oligonucleotides	oligonucleotide	NOUN
dti-1319	702	7	recognizing	recognize	VERB
dti-1319	702	8	rna	rna	NOUN
dti-1319	702	9	structure	structure	NOUN
dti-1319	702	10	.	.	PUNCT
dti-1319	703	1	prog	prog	NOUN
dti-1319	703	2	.	.	PUNCT
dti-1319	704	1	nucleic	nucleic	ADJ
dti-1319	704	2	acid	acid	NOUN
dti-1319	704	3	res	re	NOUN
dti-1319	704	4	.	.	PUNCT
dti-1319	705	1	mol	mol	PROPN
dti-1319	705	2	.	.	PUNCT
dti-1319	706	1	biol	biol	PROPN
dti-1319	706	2	.	.	PUNCT
dti-1319	706	3	,	,	PUNCT
dti-1319	706	4	69:1–46	69:1–46	NUM
dti-1319	706	5	.	.	PUNCT
dti-1319	707	1	turner	turner	PROPN
dti-1319	707	2	,	,	PUNCT
dti-1319	707	3	j.j	j.j	PROPN
dti-1319	707	4	.	.	PROPN
dti-1319	707	5	,	,	PUNCT
dti-1319	707	6	ivanova	ivanova	PROPN
dti-1319	707	7	,	,	PUNCT
dti-1319	707	8	g.d	g.d	PROPN
dti-1319	707	9	.	.	PROPN
dti-1319	707	10	,	,	PUNCT
dti-1319	707	11	verbeure	verbeure	NOUN
dti-1319	707	12	,	,	PUNCT
dti-1319	707	13	b.	b.	PROPN
dti-1319	707	14	,	,	PUNCT
dti-1319	707	15	et	et	PROPN
dti-1319	707	16	al	al	PROPN
dti-1319	707	17	.	.	PROPN
dti-1319	707	18	2005	2005	NUM
dti-1319	707	19	.	.	PUNCT
dti-1319	708	1	cell	cell	NOUN
dti-1319	708	2	-	-	PUNCT
dti-1319	708	3	penetrating	penetrate	VERB
dti-1319	708	4	peptide	peptide	NOUN
dti-1319	708	5	conjugates	conjugate	NOUN
dti-1319	708	6	of	of	ADP
dti-1319	708	7	peptide	peptide	ADJ
dti-1319	708	8	nucleic	nucleic	ADJ
dti-1319	708	9	acids	acid	NOUN
dti-1319	708	10	(	(	PUNCT
dti-1319	708	11	pna	pna	NOUN
dti-1319	708	12	)	)	PUNCT
dti-1319	708	13	as	as	ADP
dti-1319	708	14	inhibitors	inhibitor	NOUN
dti-1319	708	15	of	of	ADP
dti-1319	708	16	hiv-1	hiv-1	PUNCT
dti-1319	708	17	tatdependent	tatdependent	ADJ
dti-1319	708	18	trans	trans	NOUN
dti-1319	708	19	-	-	NOUN
dti-1319	708	20	activation	activation	NOUN
dti-1319	708	21	in	in	ADP
dti-1319	708	22	cells	cell	NOUN
dti-1319	708	23	.	.	PUNCT
dti-1319	709	1	nucleic	nucleic	ADJ
dti-1319	709	2	acids	acid	NOUN
dti-1319	709	3	res	re	NOUN
dti-1319	709	4	.	.	PUNCT
dti-1319	709	5	,	,	PUNCT
dti-1319	709	6	33:6837–49	33:6837–49	NUM
dti-1319	709	7	.	.	PUNCT
dti-1319	710	1	tuschl	tuschl	NOUN
dti-1319	710	2	,	,	PUNCT
dti-1319	710	3	t.	t.	PROPN
dti-1319	710	4	,	,	PUNCT
dti-1319	710	5	zamore	zamore	PROPN
dti-1319	710	6	,	,	PUNCT
dti-1319	710	7	p.d	p.d	PROPN
dti-1319	710	8	.	.	PROPN
dti-1319	710	9	,	,	PUNCT
dti-1319	710	10	lehmann	lehmann	PROPN
dti-1319	710	11	,	,	PUNCT
dti-1319	710	12	r.	r.	PROPN
dti-1319	710	13	,	,	PUNCT
dti-1319	710	14	et	et	PROPN
dti-1319	710	15	al	al	PROPN
dti-1319	710	16	.	.	PROPN
dti-1319	710	17	1999	1999	NUM
dti-1319	710	18	.	.	PUNCT
dti-1319	711	1	targeted	target	VERB
dti-1319	711	2	mrna	mrna	PROPN
dti-1319	711	3	degradation	degradation	NOUN
dti-1319	711	4	by	by	ADP
dti-1319	711	5	double	double	ADJ
dti-1319	711	6	-	-	PUNCT
dti-1319	711	7	stranded	strand	VERB
dti-1319	711	8	rna	rna	NOUN
dti-1319	711	9	in	in	ADP
dti-1319	711	10	vitro	vitro	X
dti-1319	711	11	.	.	PUNCT
dti-1319	712	1	genes	gene	NOUN
dti-1319	712	2	dev	dev	PROPN
dti-1319	712	3	.	.	PROPN
dti-1319	712	4	,	,	PUNCT
dti-1319	712	5	13:3191–7	13:3191–7	X
dti-1319	712	6	.	.	PUNCT
dti-1319	713	1	ulrich	ulrich	PROPN
dti-1319	713	2	,	,	PUNCT
dti-1319	713	3	h.	h.	PROPN
dti-1319	713	4	,	,	PUNCT
dti-1319	713	5	ippolito	ippolito	PROPN
dti-1319	713	6	,	,	PUNCT
dti-1319	713	7	j.e	j.e	PROPN
dti-1319	713	8	.	.	PROPN
dti-1319	713	9	,	,	PUNCT
dti-1319	713	10	pagan	pagan	PROPN
dti-1319	713	11	,	,	PUNCT
dti-1319	713	12	o.r	o.r	PROPN
dti-1319	713	13	.	.	PROPN
dti-1319	713	14	,	,	PUNCT
dti-1319	713	15	et	et	PROPN
dti-1319	713	16	al	al	PROPN
dti-1319	713	17	.	.	PROPN
dti-1319	713	18	1998	1998	NUM
dti-1319	713	19	.	.	PUNCT
dti-1319	714	1	in	in	ADP
dti-1319	714	2	vitro	vitro	X
dti-1319	714	3	selection	selection	NOUN
dti-1319	714	4	of	of	ADP
dti-1319	714	5	rna	rna	NOUN
dti-1319	714	6	molecules	molecule	NOUN
dti-1319	714	7	that	that	PRON
dti-1319	714	8	displace	displace	VERB
dti-1319	714	9	cocaine	cocaine	NOUN
dti-1319	714	10	from	from	ADP
dti-1319	714	11	the	the	DET
dti-1319	714	12	membrane	membrane	NOUN
dti-1319	714	13	-	-	PUNCT
dti-1319	714	14	bound	bind	VERB
dti-1319	714	15	nicotinic	nicotinic	ADJ
dti-1319	714	16	acetylcholine	acetylcholine	NOUN
dti-1319	714	17	receptor	receptor	NOUN
dti-1319	714	18	.	.	PUNCT
dti-1319	715	1	proc	proc	NOUN
dti-1319	715	2	.	.	PUNCT
dti-1319	716	1	natl	natl	PROPN
dti-1319	716	2	.	.	PUNCT
dti-1319	717	1	acad	acad	PROPN
dti-1319	717	2	.	.	PUNCT
dti-1319	718	1	sci	sci	PROPN
dti-1319	718	2	.	.	PUNCT
dti-1319	718	3	u.s.a	u.s.a	PROPN
dti-1319	718	4	.	.	PROPN
dti-1319	718	5	,	,	PUNCT
dti-1319	718	6	95:14051–6	95:14051–6	NUM
dti-1319	718	7	.	.	PUNCT
dti-1319	719	1	ulrich	ulrich	PROPN
dti-1319	719	2	,	,	PUNCT
dti-1319	719	3	h.	h.	PROPN
dti-1319	719	4	,	,	PUNCT
dti-1319	719	5	magdesian	magdesian	PROPN
dti-1319	719	6	,	,	PUNCT
dti-1319	719	7	m.h	m.h	PROPN
dti-1319	719	8	.	.	PROPN
dti-1319	719	9	,	,	PUNCT
dti-1319	719	10	alves	alves	PROPN
dti-1319	719	11	,	,	PUNCT
dti-1319	719	12	m.j	m.j	PROPN
dti-1319	719	13	.	.	PROPN
dti-1319	719	14	and	and	CCONJ
dti-1319	719	15	colli	colli	PROPN
dti-1319	719	16	,	,	PUNCT
dti-1319	719	17	w.	w.	PROPN
dti-1319	719	18	2002	2002	NUM
dti-1319	719	19	.	.	PUNCT
dti-1319	720	1	in	in	ADP
dti-1319	720	2	vitro	vitro	X
dti-1319	720	3	selection	selection	NOUN
dti-1319	720	4	of	of	ADP
dti-1319	720	5	rna	rna	NOUN
dti-1319	720	6	aptamers	aptamer	NOUN
dti-1319	720	7	that	that	PRON
dti-1319	720	8	bind	bind	VERB
dti-1319	720	9	to	to	ADP
dti-1319	720	10	cell	cell	NOUN
dti-1319	720	11	adhesion	adhesion	NOUN
dti-1319	720	12	receptors	receptor	NOUN
dti-1319	720	13	of	of	ADP
dti-1319	720	14	trypanosoma	trypanosoma	PROPN
dti-1319	720	15	cruzi	cruzi	PROPN
dti-1319	720	16	and	and	CCONJ
dti-1319	720	17	inhibit	inhibit	VERB
dti-1319	720	18	cell	cell	NOUN
dti-1319	720	19	invasion	invasion	NOUN
dti-1319	720	20	.	.	PUNCT
dti-1319	721	1	j.	j.	PROPN
dti-1319	721	2	biol	biol	PROPN
dti-1319	721	3	.	.	PUNCT
dti-1319	722	1	chem	chem	PROPN
dti-1319	722	2	.	.	PUNCT
dti-1319	722	3	,	,	PUNCT
dti-1319	723	1	277:20756–62	277:20756–62	NUM
dti-1319	723	2	.	.	PUNCT
dti-1319	723	3	ulrich	ulrich	PROPN
dti-1319	723	4	,	,	PUNCT
dti-1319	723	5	h.	h.	PROPN
dti-1319	723	6	,	,	PUNCT
dti-1319	723	7	martins	martin	NOUN
dti-1319	723	8	,	,	PUNCT
dti-1319	723	9	a.h.b	a.h.b	NOUN
dti-1319	723	10	.	.	PUNCT
dti-1319	723	11	and	and	CCONJ
dti-1319	723	12	pesquero	pesquero	NOUN
dti-1319	723	13	,	,	PUNCT
dti-1319	723	14	j.b	j.b	PROPN
dti-1319	723	15	.	.	PROPN
dti-1319	723	16	2004	2004	NUM
dti-1319	723	17	.	.	PUNCT
dti-1319	724	1	rna	rna	NOUN
dti-1319	724	2	and	and	CCONJ
dti-1319	724	3	dna	dna	PROPN
dti-1319	724	4	aptamers	aptamer	NOUN
dti-1319	724	5	in	in	ADP
dti-1319	724	6	cytomics	cytomic	NOUN
dti-1319	724	7	analysis	analysis	NOUN
dti-1319	724	8	.	.	PUNCT
dti-1319	725	1	cytometry	cytometry	NOUN
dti-1319	725	2	,	,	PUNCT
dti-1319	725	3	59a:220–31	59a:220–31	NUM
dti-1319	725	4	.	.	PUNCT
dti-1319	726	1	ulrich	ulrich	PROPN
dti-1319	726	2	,	,	PUNCT
dti-1319	726	3	h.	h.	PROPN
dti-1319	726	4	,	,	PUNCT
dti-1319	726	5	trujillo	trujillo	PROPN
dti-1319	726	6	,	,	PUNCT
dti-1319	726	7	c.a	c.a	PROPN
dti-1319	726	8	.	.	PROPN
dti-1319	726	9	,	,	PUNCT
dti-1319	726	10	nery	nery	PROPN
dti-1319	726	11	,	,	PUNCT
dti-1319	726	12	a.a	a.a	PROPN
dti-1319	726	13	.	.	PROPN
dti-1319	726	14	,	,	PUNCT
dti-1319	726	15	et	et	PROPN
dti-1319	726	16	al	al	PROPN
dti-1319	726	17	.	.	PROPN
dti-1319	726	18	2006	2006	NUM
dti-1319	726	19	.	.	PUNCT
dti-1319	727	1	dna	dna	PROPN
dti-1319	727	2	and	and	CCONJ
dti-1319	727	3	rna	rna	NOUN
dti-1319	727	4	aptamers	aptamer	NOUN
dti-1319	727	5	:	:	PUNCT
dti-1319	727	6	from	from	ADP
dti-1319	727	7	tools	tool	NOUN
dti-1319	727	8	for	for	ADP
dti-1319	727	9	basic	basic	ADJ
dti-1319	727	10	research	research	NOUN
dti-1319	727	11	towards	towards	ADP
dti-1319	727	12	therapeutic	therapeutic	ADJ
dti-1319	727	13	applications	application	NOUN
dti-1319	727	14	.	.	PUNCT
dti-1319	728	1	comb	comb	NOUN
dti-1319	728	2	.	.	PUNCT
dti-1319	729	1	chem	chem	NOUN
dti-1319	729	2	.	.	PUNCT
dti-1319	730	1	high	high	ADJ
dti-1319	730	2	throughput	throughput	NOUN
dti-1319	730	3	screen	screen	NOUN
dti-1319	730	4	,	,	PUNCT
dti-1319	730	5	9:619–32	9:619–32	PROPN
dti-1319	730	6	.	.	PUNCT
dti-1319	731	1	vavvas	vavvas	PROPN
dti-1319	731	2	,	,	PUNCT
dti-1319	731	3	d.	d.	PROPN
dti-1319	731	4	and	and	CCONJ
dti-1319	731	5	d’amico	d’amico	PROPN
dti-1319	731	6	,	,	PUNCT
dti-1319	731	7	d.j	d.j	PROPN
dti-1319	731	8	.	.	PROPN
dti-1319	731	9	2006	2006	NUM
dti-1319	731	10	.	.	PUNCT
dti-1319	732	1	pegaptanib	pegaptanib	NOUN
dti-1319	732	2	(	(	PUNCT
dti-1319	732	3	macugen	macugen	PROPN
dti-1319	732	4	):	):	PUNCT
dti-1319	732	5	treating	treat	VERB
dti-1319	732	6	neovascular	neovascular	PROPN
dti-1319	732	7	age	age	NOUN
dti-1319	732	8	-	-	PUNCT
dti-1319	732	9	related	relate	VERB
dti-1319	732	10	macular	macular	ADJ
dti-1319	732	11	degeneration	degeneration	NOUN
dti-1319	732	12	and	and	CCONJ
dti-1319	732	13	current	current	ADJ
dti-1319	732	14	role	role	NOUN
dti-1319	732	15	in	in	ADP
dti-1319	732	16	clinical	clinical	ADJ
dti-1319	732	17	practice	practice	NOUN
dti-1319	732	18	.	.	PUNCT
dti-1319	733	1	ophthalmol	ophthalmol	PROPN
dti-1319	733	2	clin	clin	PROPN
dti-1319	733	3	.	.	PUNCT
dti-1319	734	1	north	north	PROPN
dti-1319	734	2	am	am	PROPN
dti-1319	734	3	.	.	PUNCT
dti-1319	734	4	,	,	PUNCT
dti-1319	734	5	19:353–60	19:353–60	NOUN
dti-1319	734	6	.	.	PUNCT
dti-1319	735	1	veenendaal	veenendaal	PROPN
dti-1319	735	2	,	,	PUNCT
dti-1319	735	3	l.m	l.m	PROPN
dti-1319	735	4	.	.	PROPN
dti-1319	735	5	,	,	PUNCT
dti-1319	735	6	jin	jin	PROPN
dti-1319	735	7	,	,	PUNCT
dti-1319	735	8	h.	h.	PROPN
dti-1319	735	9	,	,	PUNCT
dti-1319	735	10	ran	run	VERB
dti-1319	735	11	,	,	PUNCT
dti-1319	735	12	s.	s.	PROPN
dti-1319	735	13	,	,	PUNCT
dti-1319	735	14	et	et	PROPN
dti-1319	735	15	al	al	PROPN
dti-1319	735	16	.	.	PROPN
dti-1319	735	17	2002	2002	NUM
dti-1319	735	18	.	.	PUNCT
dti-1319	736	1	in	in	ADP
dti-1319	736	2	vitro	vitro	X
dti-1319	736	3	and	and	CCONJ
dti-1319	736	4	in	in	ADP
dti-1319	736	5	vivo	vivo	ADJ
dti-1319	736	6	studies	study	NOUN
dti-1319	736	7	of	of	ADP
dti-1319	736	8	a	a	DET
dti-1319	736	9	vegf121	vegf121	PROPN
dti-1319	736	10	/	/	SYM
dti-1319	736	11	rgelonin	rgelonin	NOUN
dti-1319	736	12	chimeric	chimeric	ADJ
dti-1319	736	13	fusion	fusion	NOUN
dti-1319	736	14	toxin	toxin	NOUN
dti-1319	736	15	targeting	target	VERB
dti-1319	736	16	the	the	DET
dti-1319	736	17	neovasculature	neovasculature	NOUN
dti-1319	736	18	of	of	ADP
dti-1319	736	19	solid	solid	ADJ
dti-1319	736	20	tumors	tumor	NOUN
dti-1319	736	21	.	.	PUNCT
dti-1319	737	1	proc	proc	NOUN
dti-1319	737	2	.	.	PUNCT
dti-1319	738	1	natl	natl	PROPN
dti-1319	738	2	.	.	PUNCT
dti-1319	739	1	acad	acad	PROPN
dti-1319	739	2	.	.	PUNCT
dti-1319	740	1	sci	sci	PROPN
dti-1319	740	2	.	.	PUNCT
dti-1319	740	3	u.s.a	u.s.a	PROPN
dti-1319	740	4	.	.	PROPN
dti-1319	740	5	,	,	PUNCT
dti-1319	740	6	99:7866–71	99:7866–71	NUM
dti-1319	740	7	.	.	PUNCT
dti-1319	741	1	vornlocher	vornlocher	PROPN
dti-1319	741	2	,	,	PUNCT
dti-1319	741	3	h.p	h.p	PROPN
dti-1319	741	4	.	.	PROPN
dti-1319	741	5	,	,	PUNCT
dti-1319	741	6	zimmermann	zimmermann	PROPN
dti-1319	741	7	,	,	PUNCT
dti-1319	741	8	t.s	t.s	PROPN
dti-1319	741	9	.	.	PROPN
dti-1319	741	10	,	,	PUNCT
dti-1319	741	11	manoharan	manoharan	NOUN
dti-1319	741	12	,	,	PUNCT
dti-1319	741	13	m.	m.	NOUN
dti-1319	741	14	,	,	PUNCT
dti-1319	741	15	et	et	NOUN
dti-1319	741	16	al.2005	al.2005	NOUN
dti-1319	741	17	a.	a.	NOUN
dti-1319	741	18	nuclease	nuclease	NOUN
dti-1319	741	19	-	-	PUNCT
dti-1319	741	20	resistant	resistant	ADJ
dti-1319	741	21	double	double	ADJ
dti-1319	741	22	-	-	PUNCT
dti-1319	741	23	stranded	strand	VERB
dti-1319	741	24	rna	rna	NOUN
dti-1319	741	25	for	for	ADP
dti-1319	741	26	rna	rna	NOUN
dti-1319	741	27	interference	interference	NOUN
dti-1319	741	28	.	.	PUNCT
dti-1319	742	1	patent	patent	NOUN
dti-1319	742	2	cooperation	cooperation	PROPN
dti-1319	742	3	treaty	treaty	NOUN
dti-1319	742	4	international	international	PROPN
dti-1319	742	5	application	application	NOUN
dti-1319	742	6	wo2005115481	wo2005115481	PROPN
dti-1319	742	7	.	.	PUNCT
dti-1319	743	1	weiner	weiner	NOUN
dti-1319	743	2	,	,	PUNCT
dti-1319	743	3	l.m	l.m	PROPN
dti-1319	743	4	.	.	PROPN
dti-1319	743	5	and	and	CCONJ
dti-1319	743	6	adams	adams	PROPN
dti-1319	743	7	,	,	PUNCT
dti-1319	743	8	g.p	g.p	PROPN
dti-1319	743	9	.	.	PROPN
dti-1319	743	10	2000	2000	NUM
dti-1319	743	11	.	.	PUNCT
dti-1319	744	1	new	new	ADJ
dti-1319	744	2	approaches	approach	NOUN
dti-1319	744	3	to	to	ADP
dti-1319	744	4	antibody	antibody	NOUN
dti-1319	744	5	therapy	therapy	NOUN
dti-1319	744	6	.	.	PUNCT
dti-1319	745	1	oncogene	oncogene	NOUN
dti-1319	745	2	,	,	PUNCT
dti-1319	745	3	19:6144–51	19:6144–51	NUM
dti-1319	745	4	.	.	PUNCT
dti-1319	745	5	werstuck	werstuck	PROPN
dti-1319	745	6	,	,	PUNCT
dti-1319	745	7	g.	g.	PROPN
dti-1319	745	8	and	and	CCONJ
dti-1319	745	9	green	green	PROPN
dti-1319	745	10	,	,	PUNCT
dti-1319	745	11	m.r	m.r	PROPN
dti-1319	745	12	.	.	PROPN
dti-1319	745	13	1998	1998	NUM
dti-1319	745	14	.	.	PUNCT
dti-1319	746	1	controlling	control	VERB
dti-1319	746	2	gene	gene	NOUN
dti-1319	746	3	expression	expression	NOUN
dti-1319	746	4	in	in	ADP
dti-1319	746	5	living	living	NOUN
dti-1319	746	6	cells	cell	NOUN
dti-1319	746	7	through	through	ADP
dti-1319	746	8	small	small	ADJ
dti-1319	746	9	molecule	molecule	NOUN
dti-1319	746	10	-	-	PUNCT
dti-1319	746	11	rna	rna	NOUN
dti-1319	746	12	interactions	interaction	NOUN
dti-1319	746	13	.	.	PUNCT
dti-1319	747	1	science	science	NOUN
dti-1319	747	2	,	,	PUNCT
dti-1319	747	3	282:296–8	282:296–8	NUM
dti-1319	747	4	.	.	PUNCT
dti-1319	747	5	wianny	wianny	PROPN
dti-1319	747	6	,	,	PUNCT
dti-1319	747	7	f.	f.	PROPN
dti-1319	747	8	and	and	CCONJ
dti-1319	747	9	zernicka	zernicka	PROPN
dti-1319	747	10	-	-	PUNCT
dti-1319	747	11	goetz	goetz	PROPN
dti-1319	747	12	,	,	PUNCT
dti-1319	747	13	m.	m.	NOUN
dti-1319	747	14	2000	2000	NUM
dti-1319	747	15	.	.	PUNCT
dti-1319	748	1	specifi	specifi	PROPN
dti-1319	748	2	c	c	PROPN
dti-1319	748	3	interference	interference	NOUN
dti-1319	748	4	with	with	ADP
dti-1319	748	5	gene	gene	NOUN
dti-1319	748	6	function	function	NOUN
dti-1319	748	7	by	by	ADP
dti-1319	748	8	double	double	ADJ
dti-1319	748	9	-	-	PUNCT
dti-1319	748	10	stranded	strand	VERB
dti-1319	748	11	rna	rna	NOUN
dti-1319	748	12	in	in	ADP
dti-1319	748	13	early	early	ADJ
dti-1319	748	14	mouse	mouse	NOUN
dti-1319	748	15	development	development	NOUN
dti-1319	748	16	.	.	PUNCT
dti-1319	749	1	nat	nat	PROPN
dti-1319	749	2	.	.	PUNCT
dti-1319	750	1	cell	cell	PROPN
dti-1319	750	2	biol	biol	PROPN
dti-1319	750	3	.	.	PUNCT
dti-1319	750	4	,	,	PUNCT
dti-1319	750	5	2:70–5	2:70–5	NUM
dti-1319	750	6	.	.	PUNCT
dti-1319	751	1	wightman	wightman	PROPN
dti-1319	751	2	,	,	PUNCT
dti-1319	751	3	b.	b.	PROPN
dti-1319	751	4	,	,	PUNCT
dti-1319	751	5	ha	ha	INTJ
dti-1319	751	6	,	,	PUNCT
dti-1319	751	7	i.	i.	NOUN
dti-1319	751	8	and	and	CCONJ
dti-1319	751	9	ruykun	ruykun	NOUN
dti-1319	751	10	,	,	PUNCT
dti-1319	751	11	g.	g.	PROPN
dti-1319	751	12	1993	1993	NUM
dti-1319	751	13	.	.	PUNCT
dti-1319	752	1	posttranscriptional	posttranscriptional	ADJ
dti-1319	752	2	regulation	regulation	NOUN
dti-1319	752	3	of	of	ADP
dti-1319	752	4	the	the	DET
dti-1319	752	5	heterochronic	heterochronic	ADJ
dti-1319	752	6	gene	gene	NOUN
dti-1319	752	7	lin-14	lin-14	NUM
dti-1319	752	8	mediates	mediate	VERB
dti-1319	752	9	temporal	temporal	ADJ
dti-1319	752	10	pattern	pattern	NOUN
dti-1319	752	11	formation	formation	NOUN
dti-1319	752	12	in	in	ADP
dti-1319	752	13	c.	c.	PROPN
dti-1319	752	14	elegans	elegans	PROPN
dti-1319	752	15	.	.	PUNCT
dti-1319	753	1	cell	cell	NOUN
dti-1319	753	2	,	,	PUNCT
dti-1319	753	3	75:855–62	75:855–62	PROPN
dti-1319	753	4	.	.	PUNCT
dti-1319	754	1	wu	wu	PROPN
dti-1319	754	2	,	,	PUNCT
dti-1319	754	3	a.m.	a.m.	NOUN
dti-1319	754	4	and	and	CCONJ
dti-1319	754	5	senter	senter	PROPN
dti-1319	754	6	,	,	PUNCT
dti-1319	754	7	p.d	p.d	PROPN
dti-1319	754	8	.	.	PROPN
dti-1319	754	9	2005	2005	NUM
dti-1319	754	10	.	.	PUNCT
dti-1319	755	1	arming	arm	VERB
dti-1319	755	2	antibodies	antibodie	VERB
dti-1319	755	3	:	:	PUNCT
dti-1319	755	4	prospects	prospect	NOUN
dti-1319	755	5	and	and	CCONJ
dti-1319	755	6	challenges	challenge	NOUN
dti-1319	755	7	for	for	ADP
dti-1319	755	8	immunoconjugates	immunoconjugate	NOUN
dti-1319	755	9	.	.	PUNCT
dti-1319	756	1	nat	nat	PROPN
dti-1319	756	2	.	.	PUNCT
dti-1319	757	1	biotechnol	biotechnol	PROPN
dti-1319	757	2	.	.	PUNCT
dti-1319	757	3	,	,	PUNCT
dti-1319	757	4	23:1137–46	23:1137–46	NUM
dti-1319	757	5	.	.	PUNCT
dti-1319	758	1	wu	wu	PROPN
dti-1319	758	2	,	,	PUNCT
dti-1319	758	3	l.	l.	PROPN
dti-1319	758	4	,	,	PUNCT
dti-1319	758	5	fan	fan	PROPN
dti-1319	758	6	,	,	PUNCT
dti-1319	758	7	j.	j.	PROPN
dti-1319	758	8	and	and	CCONJ
dti-1319	758	9	belasco	belasco	PROPN
dti-1319	758	10	,	,	PUNCT
dti-1319	758	11	j.g	j.g	PROPN
dti-1319	758	12	.	.	PROPN
dti-1319	758	13	2006	2006	NUM
dti-1319	758	14	.	.	PUNCT
dti-1319	759	1	micrornas	microrna	NOUN
dti-1319	759	2	direct	direct	ADJ
dti-1319	759	3	rapid	rapid	ADJ
dti-1319	759	4	deadenylation	deadenylation	NOUN
dti-1319	759	5	of	of	ADP
dti-1319	759	6	mrna	mrna	PROPN
dti-1319	759	7	.	.	PUNCT
dti-1319	760	1	proc	proc	PROPN
dti-1319	760	2	.	.	PUNCT
dti-1319	761	1	natl	natl	PROPN
dti-1319	761	2	.	.	PUNCT
dti-1319	762	1	acad	acad	PROPN
dti-1319	762	2	.	.	PUNCT
dti-1319	763	1	sci	sci	PROPN
dti-1319	763	2	.	.	PUNCT
dti-1319	763	3	u.s.a	u.s.a	PROPN
dti-1319	763	4	.	.	PROPN
dti-1319	763	5	,	,	PUNCT
dti-1319	763	6	103:4034–9	103:4034–9	PROPN
dti-1319	763	7	.	.	PUNCT
dti-1319	764	1	xia	xia	PROPN
dti-1319	764	2	,	,	PUNCT
dti-1319	764	3	h.	h.	PROPN
dti-1319	764	4	,	,	PUNCT
dti-1319	764	5	mao	mao	PROPN
dti-1319	764	6	,	,	PUNCT
dti-1319	764	7	q.	q.	PROPN
dti-1319	764	8	,	,	PUNCT
dti-1319	764	9	eliason	eliason	PROPN
dti-1319	764	10	,	,	PUNCT
dti-1319	764	11	s.l	s.l	PROPN
dti-1319	764	12	.	.	PROPN
dti-1319	764	13	,	,	PUNCT
dti-1319	764	14	et	et	PROPN
dti-1319	764	15	al	al	PROPN
dti-1319	764	16	.	.	PROPN
dti-1319	764	17	2004	2004	NUM
dti-1319	764	18	.	.	PUNCT
dti-1319	765	1	rnai	rnai	PROPN
dti-1319	765	2	suppresses	suppress	VERB
dti-1319	765	3	polyglutamineinduced	polyglutamineinduce	VERB
dti-1319	765	4	neurodegeneration	neurodegeneration	NOUN
dti-1319	765	5	in	in	ADP
dti-1319	765	6	a	a	DET
dti-1319	765	7	model	model	NOUN
dti-1319	765	8	of	of	ADP
dti-1319	765	9	spinocerebellar	spinocerebellar	ADJ
dti-1319	765	10	ataxia	ataxia	NOUN
dti-1319	765	11	.	.	PUNCT
dti-1319	766	1	nat	nat	PROPN
dti-1319	766	2	.	.	PUNCT
dti-1319	767	1	med	med	PROPN
dti-1319	767	2	.	.	PROPN
dti-1319	767	3	,	,	PUNCT
dti-1319	767	4	10:816–20	10:816–20	NUM
dti-1319	767	5	.	.	PUNCT
dti-1319	768	1	196	196	NUM
dti-1319	768	2	ulrich	ulrich	PROPN
dti-1319	768	3	et	et	PROPN
dti-1319	768	4	al	al	PROPN
dti-1319	768	5	drug	drug	PROPN
dti-1319	768	6	target	target	NOUN
dti-1319	768	7	insights	insight	NOUN
dti-1319	768	8	2007:2	2007:2	NUM
dti-1319	768	9	yano	yano	PROPN
dti-1319	768	10	,	,	PUNCT
dti-1319	768	11	j.	j.	PROPN
dti-1319	768	12	,	,	PUNCT
dti-1319	768	13	hirabayashi	hirabayashi	PROPN
dti-1319	768	14	,	,	PUNCT
dti-1319	768	15	k.	k.	PROPN
dti-1319	768	16	,	,	PUNCT
dti-1319	768	17	nakagawa	nakagawa	PROPN
dti-1319	768	18	,	,	PUNCT
dti-1319	768	19	s.	s.	PROPN
dti-1319	768	20	,	,	PUNCT
dti-1319	768	21	et	et	PROPN
dti-1319	768	22	al	al	PROPN
dti-1319	768	23	.	.	PROPN
dti-1319	768	24	2004	2004	NUM
dti-1319	768	25	.	.	PUNCT
dti-1319	769	1	antitumor	antitumor	NOUN
dti-1319	769	2	activity	activity	NOUN
dti-1319	769	3	of	of	ADP
dti-1319	769	4	small	small	ADJ
dti-1319	769	5	interfering	interfere	VERB
dti-1319	769	6	rna	rna	NOUN
dti-1319	769	7	/	/	SYM
dti-1319	769	8	cationic	cationic	ADJ
dti-1319	769	9	liposome	liposome	NOUN
dti-1319	769	10	complex	complex	NOUN
dti-1319	769	11	in	in	ADP
dti-1319	769	12	mouse	mouse	NOUN
dti-1319	769	13	models	model	NOUN
dti-1319	769	14	of	of	ADP
dti-1319	769	15	cancer	cancer	NOUN
dti-1319	769	16	.	.	PUNCT
dti-1319	770	1	clin	clin	PROPN
dti-1319	770	2	.	.	PUNCT
dti-1319	771	1	cancer	cancer	NOUN
dti-1319	771	2	res	re	NOUN
dti-1319	771	3	.	.	PUNCT
dti-1319	771	4	,	,	PUNCT
dti-1319	771	5	10:7721–6	10:7721–6	NUM
dti-1319	771	6	.	.	PUNCT
dti-1319	772	1	yekta	yekta	NOUN
dti-1319	772	2	,	,	PUNCT
dti-1319	772	3	s.	s.	PROPN
dti-1319	772	4	,	,	PUNCT
dti-1319	772	5	shih	shih	PROPN
dti-1319	772	6	,	,	PUNCT
dti-1319	772	7	i.h	i.h	PROPN
dti-1319	772	8	.	.	PROPN
dti-1319	772	9	and	and	CCONJ
dti-1319	772	10	bartel	bartel	PROPN
dti-1319	772	11	,	,	PUNCT
dti-1319	772	12	d.p	d.p	PROPN
dti-1319	772	13	.	.	PROPN
dti-1319	772	14	2004	2004	NUM
dti-1319	772	15	.	.	PUNCT
dti-1319	773	1	microrna	microrna	PROPN
dti-1319	773	2	-	-	PUNCT
dti-1319	773	3	directed	direct	VERB
dti-1319	773	4	cleavage	cleavage	NOUN
dti-1319	773	5	of	of	ADP
dti-1319	773	6	hoxb8	hoxb8	PROPN
dti-1319	773	7	mrna	mrna	PROPN
dti-1319	773	8	.	.	PUNCT
dti-1319	774	1	science	science	PROPN
dti-1319	774	2	,	,	PUNCT
dti-1319	774	3	304:594–6	304:594–6	PROPN
dti-1319	774	4	.	.	PUNCT
dti-1319	775	1	yoshinari	yoshinari	PROPN
dti-1319	775	2	,	,	PUNCT
dti-1319	775	3	k.	k.	PROPN
dti-1319	775	4	,	,	PUNCT
dti-1319	775	5	miyagishi	miyagishi	PROPN
dti-1319	775	6	,	,	PUNCT
dti-1319	775	7	m.	m.	NOUN
dti-1319	775	8	and	and	CCONJ
dti-1319	775	9	taira	taira	PROPN
dti-1319	775	10	,	,	PUNCT
dti-1319	775	11	k.	k.	PROPN
dti-1319	775	12	2004	2004	NUM
dti-1319	775	13	.	.	PUNCT
dti-1319	776	1	effects	effect	NOUN
dti-1319	776	2	on	on	ADP
dti-1319	776	3	rnai	rnai	PROPN
dti-1319	776	4	of	of	ADP
dti-1319	776	5	the	the	DET
dti-1319	776	6	tight	tight	ADJ
dti-1319	776	7	structure	structure	NOUN
dti-1319	776	8	,	,	PUNCT
dti-1319	776	9	sequence	sequence	NOUN
dti-1319	776	10	and	and	CCONJ
dti-1319	776	11	position	position	NOUN
dti-1319	776	12	of	of	ADP
dti-1319	776	13	the	the	DET
dti-1319	776	14	targeted	target	VERB
dti-1319	776	15	region	region	NOUN
dti-1319	776	16	.	.	PUNCT
dti-1319	777	1	nucleic	nucleic	ADJ
dti-1319	777	2	acids	acid	NOUN
dti-1319	777	3	res	re	NOUN
dti-1319	777	4	.	.	PUNCT
dti-1319	777	5	,	,	PUNCT
dti-1319	777	6	32:691–9	32:691–9	NUM
dti-1319	777	7	.	.	PUNCT
dti-1319	778	1	zamore	zamore	PROPN
dti-1319	778	2	,	,	PUNCT
dti-1319	778	3	p.d	p.d	PROPN
dti-1319	778	4	.	.	PROPN
dti-1319	778	5	,	,	PUNCT
dti-1319	778	6	tuschl	tuschl	NOUN
dti-1319	778	7	,	,	PUNCT
dti-1319	778	8	t.	t.	PROPN
dti-1319	778	9	,	,	PUNCT
dti-1319	778	10	sharp	sharp	ADJ
dti-1319	778	11	,	,	PUNCT
dti-1319	778	12	p.a	p.a	PROPN
dti-1319	778	13	.	.	PROPN
dti-1319	778	14	,	,	PUNCT
dti-1319	778	15	et	et	PROPN
dti-1319	778	16	al	al	PROPN
dti-1319	778	17	.	.	PROPN
dti-1319	778	18	2000	2000	NUM
dti-1319	778	19	.	.	PUNCT
dti-1319	779	1	rnai	rnai	PROPN
dti-1319	779	2	:	:	PUNCT
dti-1319	779	3	double	double	ADJ
dti-1319	779	4	-	-	PUNCT
dti-1319	779	5	stranded	strand	VERB
dti-1319	779	6	rna	rna	NOUN
dti-1319	779	7	directs	direct	VERB
dti-1319	779	8	the	the	DET
dti-1319	779	9	atp	atp	NOUN
dti-1319	779	10	-	-	PUNCT
dti-1319	779	11	dependent	dependent	ADJ
dti-1319	779	12	cleavage	cleavage	NOUN
dti-1319	779	13	of	of	ADP
dti-1319	779	14	mrna	mrna	PROPN
dti-1319	779	15	at	at	ADP
dti-1319	779	16	21	21	NUM
dti-1319	779	17	to	to	PART
dti-1319	779	18	23	23	NUM
dti-1319	779	19	nucleotide	nucleotide	NOUN
dti-1319	779	20	intervals	interval	NOUN
dti-1319	779	21	.	.	PUNCT
dti-1319	780	1	cell	cell	NOUN
dti-1319	780	2	,	,	PUNCT
dti-1319	780	3	101:25–33	101:25–33	NUM
dti-1319	780	4	.	.	PUNCT
dti-1319	781	1	zhang	zhang	PROPN
dti-1319	781	2	,	,	PUNCT
dti-1319	781	3	y.	y.	PROPN
dti-1319	781	4	,	,	PUNCT
dti-1319	781	5	zhang	zhang	PROPN
dti-1319	781	6	,	,	PUNCT
dti-1319	781	7	y.f	y.f	PROPN
dti-1319	781	8	.	.	PROPN
dti-1319	781	9	,	,	PUNCT
dti-1319	781	10	bryant	bryant	PROPN
dti-1319	781	11	j	j	PROPN
dti-1319	781	12	et	et	PROPN
dti-1319	781	13	al	al	PROPN
dti-1319	781	14	.	.	PROPN
dti-1319	781	15	2004	2004	NUM
dti-1319	781	16	.	.	PUNCT
dti-1319	782	1	intravenous	intravenous	ADJ
dti-1319	782	2	rna	rna	NOUN
dti-1319	782	3	interference	interference	NOUN
dti-1319	782	4	gene	gene	NOUN
dti-1319	782	5	therapy	therapy	NOUN
dti-1319	782	6	targeting	target	VERB
dti-1319	782	7	the	the	DET
dti-1319	782	8	human	human	ADJ
dti-1319	782	9	epidermal	epidermal	ADJ
dti-1319	782	10	growth	growth	NOUN
dti-1319	782	11	factor	factor	NOUN
dti-1319	782	12	receptor	receptor	NOUN
dti-1319	782	13	prolongs	prolong	VERB
dti-1319	782	14	survival	survival	NOUN
dti-1319	782	15	in	in	ADP
dti-1319	782	16	intracranial	intracranial	ADJ
dti-1319	782	17	brain	brain	NOUN
dti-1319	782	18	cancer	cancer	NOUN
dti-1319	782	19	.	.	PUNCT
dti-1319	783	1	clin	clin	PROPN
dti-1319	783	2	.	.	PUNCT
dti-1319	784	1	cancer	cancer	NOUN
dti-1319	784	2	.	.	PUNCT
dti-1319	785	1	res	re	NOUN
dti-1319	785	2	.	.	PROPN
dti-1319	785	3	,	,	PUNCT
dti-1319	785	4	10:3667–77	10:3667–77	NUM
dti-1319	785	5	.	.	PUNCT
dti-1319	786	1	zimmermann	zimmermann	PROPN
dti-1319	786	2	,	,	PUNCT
dti-1319	786	3	g.r	g.r	PROPN
dti-1319	786	4	.	.	PROPN
dti-1319	786	5	,	,	PUNCT
dti-1319	786	6	jenison	jenison	PROPN
dti-1319	786	7	,	,	PUNCT
dti-1319	786	8	r.d	r.d	PROPN
dti-1319	786	9	.	.	PROPN
dti-1319	786	10	,	,	PUNCT
dti-1319	786	11	wick	wick	PROPN
dti-1319	786	12	,	,	PUNCT
dti-1319	786	13	c.l	c.l	PROPN
dti-1319	786	14	.	.	PROPN
dti-1319	786	15	,	,	PUNCT
dti-1319	786	16	et	et	PROPN
dti-1319	786	17	al	al	PROPN
dti-1319	786	18	.	.	PROPN
dti-1319	786	19	1997	1997	NUM
dti-1319	786	20	.	.	PUNCT
dti-1319	787	1	interlocking	interlock	VERB
dti-1319	787	2	structural	structural	ADJ
dti-1319	787	3	motifs	motif	NOUN
dti-1319	787	4	mediate	mediate	VERB
dti-1319	787	5	molecular	molecular	ADJ
dti-1319	787	6	discrimination	discrimination	NOUN
dti-1319	787	7	by	by	ADP
dti-1319	787	8	a	a	DET
dti-1319	787	9	theophyllinebinding	theophyllinebinde	VERB
dti-1319	787	10	rna	rna	NOUN
dti-1319	787	11	.	.	PUNCT
dti-1319	788	1	nat	nat	PROPN
dti-1319	788	2	.	.	PUNCT
dti-1319	788	3	struct	struct	NOUN
dti-1319	788	4	.	.	PUNCT
dti-1319	789	1	biol	biol	PROPN
dti-1319	789	2	.	.	PUNCT
dti-1319	789	3	,	,	PUNCT
dti-1319	789	4	4:644–9	4:644–9	X
dti-1319	789	5	.	.	PUNCT
dti-1319	790	1	zimmermann	zimmermann	PROPN
dti-1319	790	2	,	,	PUNCT
dti-1319	790	3	t.s	t.s	PROPN
dti-1319	790	4	.	.	PROPN
dti-1319	790	5	,	,	PUNCT
dti-1319	790	6	lee	lee	PROPN
dti-1319	790	7	,	,	PUNCT
dti-1319	790	8	a.c	a.c	PROPN
dti-1319	790	9	.	.	PROPN
dti-1319	790	10	,	,	PUNCT
dti-1319	790	11	akinc	akinc	PROPN
dti-1319	790	12	,	,	PUNCT
dti-1319	790	13	a.	a.	PROPN
dti-1319	790	14	,	,	PUNCT
dti-1319	790	15	et	et	PROPN
dti-1319	790	16	al	al	PROPN
dti-1319	790	17	.	.	PROPN
dti-1319	790	18	2006	2006	NUM
dti-1319	790	19	.	.	PUNCT
dti-1319	791	1	rnai	rnai	NOUN
dti-1319	791	2	-	-	PUNCT
dti-1319	791	3	mediated	mediate	VERB
dti-1319	791	4	gene	gene	NOUN
dti-1319	791	5	silencing	silence	VERB
dti-1319	791	6	in	in	ADP
dti-1319	791	7	non	non	ADJ
dti-1319	791	8	-	-	ADJ
dti-1319	791	9	human	human	ADJ
dti-1319	791	10	primates	primate	NOUN
dti-1319	791	11	.	.	PUNCT
dti-1319	792	1	nature	nature	NOUN
dti-1319	792	2	,	,	PUNCT
dti-1319	792	3	441:111–4	441:111–4	NOUN
dti-1319	792	4	.	.	PUNCT
dti-1319	793	1	<	<	X
dti-1319	793	2	<	<	X
dti-1319	793	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1319	793	4	false	false	ADJ
dti-1319	793	5	/allowtransparency	/allowtransparency	NOUN
dti-1319	793	6	false	false	ADJ
dti-1319	793	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1319	793	8	true	true	ADJ
dti-1319	793	9	/autorotatepages	/autorotatepage	NOUN
dti-1319	793	10	/none	/none	PUNCT
dti-1319	793	11	/binding	/binding	PUNCT
dti-1319	793	12	/left	/left	ADJ
dti-1319	794	1	/calgrayprofile	/calgrayprofile	VERB
dti-1319	794	2	(	(	PUNCT
dti-1319	794	3	dot	dot	NOUN
dti-1319	794	4	gain	gain	NOUN
dti-1319	794	5	20	20	NUM
dti-1319	794	6	%	%	NOUN
dti-1319	794	7	)	)	PUNCT
dti-1319	794	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1319	795	1	(	(	PUNCT
dti-1319	795	2	srgb	srgb	PROPN
dti-1319	795	3	iec61966	iec61966	NOUN
dti-1319	795	4	-	-	PUNCT
dti-1319	795	5	2.1	2.1	NUM
dti-1319	795	6	)	)	PUNCT
dti-1319	795	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1319	796	1	(	(	PUNCT
dti-1319	796	2	u.s	u.s	PROPN
dti-1319	796	3	.	.	PROPN
dti-1319	796	4	web	web	NOUN
dti-1319	796	5	coated	coat	VERB
dti-1319	796	6	\050swop\051	\050swop\051	ADJ
dti-1319	796	7	v2	v2	NOUN
dti-1319	796	8	)	)	PUNCT
dti-1319	796	9	/srgbprofile	/srgbprofile	PUNCT
dti-1319	796	10	(	(	PUNCT
dti-1319	796	11	srgb	srgb	PROPN
dti-1319	796	12	iec61966	iec61966	NOUN
dti-1319	796	13	-	-	PUNCT
dti-1319	796	14	2.1	2.1	NUM
dti-1319	796	15	)	)	PUNCT
dti-1319	796	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1319	797	1	/error	/error	INTJ
dti-1319	797	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1319	798	1	1.4	1.4	NUM
dti-1319	798	2	/compressobjects	/compressobject	NOUN
dti-1319	798	3	/tags	/tag	VERB
dti-1319	798	4	/compresspages	/compresspage	NOUN
dti-1319	798	5	true	true	ADJ
dti-1319	798	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1319	798	7	true	true	ADJ
dti-1319	798	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1319	798	9	true	true	ADJ
dti-1319	798	10	/createjdffile	/createjdffile	ADJ
dti-1319	798	11	false	false	ADJ
dti-1319	798	12	/createjobticket	/createjobticket	NOUN
dti-1319	798	13	false	false	ADJ
dti-1319	798	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1319	798	15	/default	/default	PUNCT
dti-1319	798	16	/detectblends	/detectblend	NOUN
dti-1319	798	17	true	true	ADJ
dti-1319	798	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1319	798	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1319	798	20	/dothumbnails	/dothumbnail	VERB
dti-1319	798	21	false	false	ADJ
dti-1319	798	22	/embedallfonts	/embedallfont	NOUN
dti-1319	798	23	true	true	ADJ
dti-1319	798	24	/embedjoboptions	/embedjoboption	NOUN
dti-1319	798	25	true	true	ADJ
dti-1319	798	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1319	798	27	0	0	NUM
dti-1319	798	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1319	798	29	false	false	ADJ
dti-1319	798	30	/endpage	/endpage	NOUN
dti-1319	798	31	-1	-1	NOUN
dti-1319	798	32	/imagememory	/imagememory	NUM
dti-1319	799	1	1048576	1048576	NUM
dti-1319	799	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1319	799	3	false	false	ADJ
dti-1319	799	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1319	799	5	100	100	NUM
dti-1319	799	6	/optimize	/optimize	NOUN
dti-1319	799	7	true	true	ADJ
dti-1319	799	8	/opm	/opm	NOUN
dti-1319	799	9	1	1	NUM
dti-1319	799	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1319	799	11	true	true	ADJ
dti-1319	799	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1319	799	13	true	true	ADJ
dti-1319	799	14	/preservecopypage	/preservecopypage	NOUN
dti-1319	799	15	true	true	ADJ
dti-1319	799	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1319	799	17	true	true	ADJ
dti-1319	799	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1319	799	19	false	false	ADJ
dti-1319	799	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1319	799	21	false	false	ADJ
dti-1319	799	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1319	799	23	true	true	ADJ
dti-1319	799	24	/startpage	/startpage	NOUN
dti-1319	799	25	1	1	NUM
dti-1319	799	26	/subsetfonts	/subsetfont	NOUN
dti-1319	799	27	true	true	ADJ
dti-1319	799	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1319	799	29	/apply	/apply	PUNCT
dti-1319	799	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1319	800	1	/preserve	/preserve	NOUN
dti-1319	800	2	/useprologue	/useprologue	NOUN
dti-1319	800	3	false	false	ADJ
dti-1319	800	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1319	800	5	(	(	PUNCT
dti-1319	800	6	)	)	PUNCT
dti-1319	800	7	/alwaysembed	/alwaysembe	VERB
dti-1319	800	8	[	[	PUNCT
dti-1319	800	9	true	true	ADJ
dti-1319	800	10	]	]	PUNCT
dti-1319	800	11	/neverembed	/neverembed	PUNCT
dti-1319	801	1	[	[	PUNCT
dti-1319	801	2	true	true	ADJ
dti-1319	801	3	]	]	PUNCT
dti-1319	801	4	/antialiascolorimages	/antialiascolorimages	X
dti-1319	801	5	false	false	ADJ
dti-1319	801	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1319	801	7	true	true	ADJ
dti-1319	801	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
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dti-1319	828	3	/dan	/dan	PUNCT
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dti-1319	830	3	>	>	X
dti-1319	830	4	/esp	/esp	PUNCT
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dti-1319	831	3	>	>	X
dti-1319	831	4	/suo	/suo	PUNCT
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dti-1319	832	3	>	>	X
dti-1319	832	4	/ita	/ita	PUNCT
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dti-1319	833	3	>	>	X
dti-1319	833	4	/nor	/nor	X
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dti-1319	833	7	>	>	X
dti-1319	833	8	/sve	/sve	NOUN
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dti-1319	834	3	>	>	X
dti-1319	834	4	/enu	/enu	PROPN
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dti-1319	834	11	>	>	X
dti-1319	834	12	setdistillerparams	setdistillerparam	NOUN
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dti-1319	835	3	/hwresolution	/hwresolution	NOUN
dti-1319	836	1	[	[	X
dti-1319	836	2	2400	2400	NUM
dti-1319	836	3	2400	2400	NUM
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dti-1319	837	1	[	[	X
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dti-1319	837	6	>	>	X
dti-1319	837	7	setpagedevice	setpagedevice	PROPN