id	sid	tid	token	lemma	pos
dti-1325	1	1	chiang	chiang	PROPN
dti-1325	1	2	et	et	PROPN
dti-1325	1	3	al.indd	al.indd	PROPN
dti-1325	1	4	drug	drug	NOUN
dti-1325	1	5	target	target	NOUN
dti-1325	1	6	insights	insight	NOUN
dti-1325	1	7	2008:3	2008:3	NUM
dti-1325	1	8	67–76	67–76	NUM
dti-1325	1	9	67	67	NUM
dti-1325	1	10	original	original	ADJ
dti-1325	1	11	research	research	NOUN
dti-1325	1	12	correspondence	correspondence	NOUN
dti-1325	1	13	:	:	PUNCT
dti-1325	1	14	thomas	thomas	PROPN
dti-1325	1	15	m.	m.	PROPN
dti-1325	1	16	chiang	chiang	PROPN
dti-1325	1	17	,	,	PUNCT
dti-1325	1	18	research	research	NOUN
dti-1325	1	19	service	service	NOUN
dti-1325	1	20	(	(	PUNCT
dti-1325	1	21	151	151	NUM
dti-1325	1	22	)	)	PUNCT
dti-1325	1	23	,	,	PUNCT
dti-1325	1	24	veterans	veterans	PROPN
dti-1325	1	25	affairs	affairs	PROPN
dti-1325	1	26	medical	medical	ADJ
dti-1325	1	27	center	center	NOUN
dti-1325	1	28	,	,	PUNCT
dti-1325	1	29	1030	1030	NUM
dti-1325	1	30	jefferson	jefferson	PROPN
dti-1325	1	31	avenue	avenue	PROPN
dti-1325	1	32	,	,	PUNCT
dti-1325	1	33	memphis	memphis	PROPN
dti-1325	1	34	,	,	PUNCT
dti-1325	1	35	tn	tn	PROPN
dti-1325	1	36	38104	38104	NUM
dti-1325	1	37	,	,	PUNCT
dti-1325	1	38	u.s.a	u.s.a	PROPN
dti-1325	1	39	.	.	PUNCT
dti-1325	2	1	tel	tel	NOUN
dti-1325	2	2	:	:	PUNCT
dti-1325	2	3	901	901	NUM
dti-1325	2	4	-	-	SYM
dti-1325	2	5	523	523	NUM
dti-1325	2	6	-	-	PUNCT
dti-1325	2	7	8990	8990	NUM
dti-1325	2	8	×	×	NOUN
dti-1325	2	9	7608	7608	NUM
dti-1325	2	10	;	;	PUNCT
dti-1325	2	11	fax	fax	NOUN
dti-1325	2	12	:	:	PUNCT
dti-1325	2	13	901	901	NUM
dti-1325	2	14	-	-	PUNCT
dti-1325	2	15	577	577	NUM
dti-1325	2	16	-	-	PUNCT
dti-1325	2	17	7273	7273	NUM
dti-1325	2	18	;	;	PUNCT
dti-1325	2	19	email:tchiang@utmem.edu	email:tchiang@utmem.edu	ADJ
dti-1325	2	20	copyright	copyright	NOUN
dti-1325	2	21	in	in	ADP
dti-1325	2	22	this	this	DET
dti-1325	2	23	article	article	NOUN
dti-1325	2	24	,	,	PUNCT
dti-1325	2	25	its	its	PRON
dti-1325	2	26	metadata	metadata	NOUN
dti-1325	2	27	,	,	PUNCT
dti-1325	2	28	and	and	CCONJ
dti-1325	2	29	any	any	DET
dti-1325	2	30	supplementary	supplementary	ADJ
dti-1325	2	31	data	datum	NOUN
dti-1325	2	32	is	be	AUX
dti-1325	2	33	held	hold	VERB
dti-1325	2	34	by	by	ADP
dti-1325	2	35	its	its	PRON
dti-1325	2	36	author	author	NOUN
dti-1325	2	37	or	or	CCONJ
dti-1325	2	38	authors	author	NOUN
dti-1325	2	39	.	.	PUNCT
dti-1325	3	1	it	it	PRON
dti-1325	3	2	is	be	AUX
dti-1325	3	3	published	publish	VERB
dti-1325	3	4	under	under	ADP
dti-1325	3	5	the	the	DET
dti-1325	3	6	creative	creative	ADJ
dti-1325	3	7	commons	common	NOUN
dti-1325	3	8	attribution	attribution	NOUN
dti-1325	3	9	by	by	ADP
dti-1325	3	10	licence	licence	NOUN
dti-1325	3	11	.	.	PUNCT
dti-1325	4	1	for	for	SCONJ
dti-1325	4	2	further	further	ADJ
dti-1325	4	3	information	information	NOUN
dti-1325	4	4	go	go	VERB
dti-1325	4	5	to	to	ADP
dti-1325	4	6	:	:	PUNCT
dti-1325	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	AUX
dti-1325	4	8	the	the	DET
dti-1325	4	9	beta3	beta3	PROPN
dti-1325	4	10	499–513	499–513	NUM
dti-1325	4	11	peptide	peptide	NOUN
dti-1325	4	12	region	region	NOUN
dti-1325	4	13	is	be	AUX
dti-1325	4	14	required	require	VERB
dti-1325	4	15	for	for	ADP
dti-1325	4	16	alphaiib/	alphaiib/	NUM
dti-1325	4	17	beta3	beta3	NOUN
dti-1325	4	18	active	active	ADJ
dti-1325	4	19	complex	complex	ADJ
dti-1325	4	20	formation	formation	NOUN
dti-1325	4	21	and	and	CCONJ
dti-1325	4	22	fibrinogen	fibrinogen	NOUN
dti-1325	4	23	binding	bind	VERB
dti-1325	4	24	virginia	virginia	PROPN
dti-1325	4	25	woo	woo	PROPN
dti-1325	4	26	-	-	PUNCT
dti-1325	4	27	rasberry1	rasberry1	PROPN
dti-1325	4	28	and	and	CCONJ
dti-1325	4	29	thomas	thomas	PROPN
dti-1325	4	30	m.	m.	PROPN
dti-1325	4	31	chiang1,2,3	chiang1,2,3	PROPN
dti-1325	4	32	1veterans	1veterans	NUM
dti-1325	4	33	affairs	affair	NOUN
dti-1325	4	34	medical	medical	ADJ
dti-1325	4	35	center	center	NOUN
dti-1325	4	36	and	and	CCONJ
dti-1325	4	37	2departments	2departments	NUM
dti-1325	4	38	of	of	ADP
dti-1325	4	39	medicine	medicine	NOUN
dti-1325	4	40	and	and	CCONJ
dti-1325	4	41	3molecular	3molecular	NUM
dti-1325	4	42	sciences	science	NOUN
dti-1325	4	43	,	,	PUNCT
dti-1325	4	44	university	university	PROPN
dti-1325	4	45	of	of	ADP
dti-1325	4	46	tennessee	tennessee	PROPN
dti-1325	4	47	health	health	PROPN
dti-1325	4	48	science	science	PROPN
dti-1325	4	49	center	center	PROPN
dti-1325	4	50	,	,	PUNCT
dti-1325	4	51	memphis	memphis	PROPN
dti-1325	4	52	,	,	PUNCT
dti-1325	4	53	tn	tn	PROPN
dti-1325	4	54	38163	38163	NUM
dti-1325	4	55	,	,	PUNCT
dti-1325	4	56	u.s.a	u.s.a	X
dti-1325	4	57	.	.	PUNCT
dti-1325	5	1	abstract	abstract	ADJ
dti-1325	5	2	background	background	NOUN
dti-1325	5	3	:	:	PUNCT
dti-1325	5	4	alphaiib	alphaiib	PROPN
dti-1325	5	5	/	/	SYM
dti-1325	5	6	beta3	beta3	NOUN
dti-1325	5	7	(	(	PUNCT
dti-1325	5	8	αiib	αiib	ADJ
dti-1325	5	9	/	/	SYM
dti-1325	5	10	β3	β3	ADJ
dti-1325	5	11	)	)	PUNCT
dti-1325	5	12	complex	complex	NOUN
dti-1325	5	13	is	be	AUX
dti-1325	5	14	an	an	DET
dti-1325	5	15	important	important	ADJ
dti-1325	5	16	integrin	integrin	NOUN
dti-1325	5	17	that	that	PRON
dti-1325	5	18	is	be	AUX
dti-1325	5	19	involved	involve	VERB
dti-1325	5	20	in	in	ADP
dti-1325	5	21	the	the	DET
dti-1325	5	22	fi	fi	NOUN
dti-1325	5	23	nal	nal	ADJ
dti-1325	5	24	step	step	NOUN
dti-1325	5	25	of	of	ADP
dti-1325	5	26	platelet	platelet	NOUN
dti-1325	5	27	aggregation	aggregation	NOUN
dti-1325	5	28	.	.	PUNCT
dti-1325	6	1	peptides	peptide	NOUN
dti-1325	6	2	derived	derive	VERB
dti-1325	6	3	from	from	ADP
dti-1325	6	4	either	either	CCONJ
dti-1325	6	5	αiib	αiib	ADJ
dti-1325	6	6	or	or	CCONJ
dti-1325	6	7	β3	β3	ADJ
dti-1325	6	8	have	have	AUX
dti-1325	6	9	demonstrated	demonstrate	VERB
dti-1325	6	10	to	to	PART
dti-1325	6	11	have	have	VERB
dti-1325	6	12	an	an	DET
dti-1325	6	13	effect	effect	NOUN
dti-1325	6	14	on	on	ADP
dti-1325	6	15	the	the	DET
dti-1325	6	16	activation	activation	NOUN
dti-1325	6	17	of	of	ADP
dti-1325	6	18	the	the	DET
dti-1325	6	19	complex	complex	NOUN
dti-1325	6	20	and	and	CCONJ
dti-1325	6	21	its	its	PRON
dti-1325	6	22	ability	ability	NOUN
dti-1325	6	23	to	to	PART
dti-1325	6	24	bind	bind	VERB
dti-1325	6	25	fi	fi	NOUN
dti-1325	6	26	brinogen	brinogen	PROPN
dti-1325	6	27	.	.	PUNCT
dti-1325	7	1	we	we	PRON
dti-1325	7	2	have	have	AUX
dti-1325	7	3	previously	previously	ADV
dti-1325	7	4	defi	defi	VERB
dti-1325	7	5	ned	ned	NOUN
dti-1325	7	6	a	a	DET
dti-1325	7	7	peptide	peptide	NOUN
dti-1325	7	8	from	from	ADP
dti-1325	7	9	β3	β3	PROPN
dti-1325	7	10	,	,	PUNCT
dti-1325	7	11	which	which	PRON
dti-1325	7	12	inhibits	inhibit	VERB
dti-1325	7	13	agonists	agonist	NOUN
dti-1325	7	14	-	-	PUNCT
dti-1325	7	15	induced	induce	VERB
dti-1325	7	16	platelet	platelet	NOUN
dti-1325	7	17	aggregation	aggregation	NOUN
dti-1325	7	18	.	.	PUNCT
dti-1325	8	1	methods	method	NOUN
dti-1325	8	2	:	:	PUNCT
dti-1325	8	3	we	we	PRON
dti-1325	8	4	used	use	VERB
dti-1325	8	5	standard	standard	ADJ
dti-1325	8	6	methodologies	methodology	NOUN
dti-1325	8	7	for	for	ADP
dti-1325	8	8	construction	construction	NOUN
dti-1325	8	9	of	of	ADP
dti-1325	8	10	clones	clone	NOUN
dti-1325	8	11	and	and	CCONJ
dti-1325	8	12	expression	expression	NOUN
dti-1325	8	13	of	of	ADP
dti-1325	8	14	cdnas	cdna	NOUN
dti-1325	8	15	,	,	PUNCT
dti-1325	8	16	establishment	establishment	NOUN
dti-1325	8	17	of	of	ADP
dti-1325	8	18	stable	stable	ADJ
dti-1325	8	19	cell	cell	NOUN
dti-1325	8	20	lines	line	NOUN
dti-1325	8	21	that	that	PRON
dti-1325	8	22	contained	contain	VERB
dti-1325	8	23	these	these	DET
dti-1325	8	24	cdnas	cdna	NOUN
dti-1325	8	25	.	.	PUNCT
dti-1325	9	1	expression	expression	NOUN
dti-1325	9	2	of	of	ADP
dti-1325	9	3	proteins	protein	NOUN
dti-1325	9	4	was	be	AUX
dti-1325	9	5	detected	detect	VERB
dti-1325	9	6	with	with	ADP
dti-1325	9	7	immunoblots	immunoblot	NOUN
dti-1325	9	8	.	.	PUNCT
dti-1325	10	1	flow	flow	NOUN
dti-1325	10	2	cytometric	cytometric	ADJ
dti-1325	10	3	analyses	analysis	NOUN
dti-1325	10	4	were	be	AUX
dti-1325	10	5	used	use	VERB
dti-1325	10	6	to	to	PART
dti-1325	10	7	verify	verify	VERB
dti-1325	10	8	the	the	DET
dti-1325	10	9	presence	presence	NOUN
dti-1325	10	10	of	of	ADP
dti-1325	10	11	the	the	DET
dti-1325	10	12	active	active	ADJ
dti-1325	10	13	and	and	CCONJ
dti-1325	10	14	inactive	inactive	ADJ
dti-1325	10	15	complexes	complex	NOUN
dti-1325	10	16	with	with	ADP
dti-1325	10	17	different	different	ADJ
dti-1325	10	18	antibodies	antibody	NOUN
dti-1325	10	19	.	.	PUNCT
dti-1325	11	1	in	in	ADP
dti-1325	11	2	addition	addition	NOUN
dti-1325	11	3	,	,	PUNCT
dti-1325	11	4	a	a	DET
dti-1325	11	5	fi	fi	NOUN
dti-1325	11	6	brinogenbinding	brinogenbinde	VERB
dti-1325	11	7	assay	assay	NOUN
dti-1325	11	8	was	be	AUX
dti-1325	11	9	used	use	VERB
dti-1325	11	10	to	to	PART
dti-1325	11	11	determine	determine	VERB
dti-1325	11	12	the	the	DET
dti-1325	11	13	inhibition	inhibition	NOUN
dti-1325	11	14	of	of	ADP
dti-1325	11	15	the	the	DET
dti-1325	11	16	active	active	ADJ
dti-1325	11	17	complex	complex	NOUN
dti-1325	11	18	by	by	ADP
dti-1325	11	19	the	the	DET
dti-1325	11	20	peptide	peptide	NOUN
dti-1325	11	21	.	.	PUNCT
dti-1325	12	1	results	result	NOUN
dti-1325	12	2	and	and	CCONJ
dti-1325	12	3	discussion	discussion	NOUN
dti-1325	12	4	:	:	PUNCT
dti-1325	12	5	a	a	DET
dti-1325	12	6	stable	stable	ADJ
dti-1325	12	7	cell	cell	NOUN
dti-1325	12	8	line	line	NOUN
dti-1325	12	9	of	of	ADP
dti-1325	12	10	the	the	DET
dti-1325	12	11	co	co	ADJ
dti-1325	12	12	-	-	ADJ
dti-1325	12	13	transfected	transfecte	VERB
dti-1325	12	14	cdnas	cdna	NOUN
dti-1325	12	15	of	of	ADP
dti-1325	12	16	αiib	αiib	NOUN
dti-1325	12	17	,	,	PUNCT
dti-1325	12	18	β3	β3	VERB
dti-1325	12	19	wild	wild	ADJ
dti-1325	12	20	type	type	NOUN
dti-1325	12	21	and	and	CCONJ
dti-1325	12	22	mutants	mutant	NOUN
dti-1325	12	23	of	of	ADP
dti-1325	12	24	β3	β3	ADJ
dti-1325	12	25	(	(	PUNCT
dti-1325	12	26	scrambled	scramble	VERB
dti-1325	12	27	sequence	sequence	NOUN
dti-1325	12	28	of	of	ADP
dti-1325	12	29	the	the	DET
dti-1325	12	30	peptide	peptide	NOUN
dti-1325	12	31	region	region	NOUN
dti-1325	12	32	,	,	PUNCT
dti-1325	12	33	replacement	replacement	NOUN
dti-1325	12	34	of	of	ADP
dti-1325	12	35	c499a	c499a	PROPN
dti-1325	12	36	and	and	CCONJ
dti-1325	12	37	c512a	c512a	PROPN
dti-1325	12	38	)	)	PUNCT
dti-1325	12	39	,	,	PUNCT
dti-1325	12	40	expressing	express	VERB
dti-1325	12	41	the	the	DET
dti-1325	12	42	inactive	inactive	ADJ
dti-1325	12	43	complex	complex	NOUN
dti-1325	12	44	on	on	ADP
dti-1325	12	45	cho	cho	NOUN
dti-1325	12	46	cells	cell	NOUN
dti-1325	12	47	,	,	PUNCT
dti-1325	12	48	has	have	AUX
dti-1325	12	49	allowed	allow	VERB
dti-1325	12	50	us	we	PRON
dti-1325	12	51	to	to	PART
dti-1325	12	52	examine	examine	VERB
dti-1325	12	53	the	the	DET
dti-1325	12	54	important	important	ADJ
dti-1325	12	55	role	role	NOUN
dti-1325	12	56	of	of	ADP
dti-1325	12	57	the	the	DET
dti-1325	12	58	peptide	peptide	NOUN
dti-1325	12	59	sequence	sequence	NOUN
dti-1325	12	60	and	and	CCONJ
dti-1325	12	61	the	the	DET
dti-1325	12	62	cysteine	cysteine	NOUN
dti-1325	12	63	residues	residue	NOUN
dti-1325	12	64	within	within	ADP
dti-1325	12	65	the	the	DET
dti-1325	12	66	peptide	peptide	NOUN
dti-1325	12	67	.	.	PUNCT
dti-1325	13	1	the	the	DET
dti-1325	13	2	peptide	peptide	NOUN
dti-1325	13	3	inhibits	inhibit	VERB
dti-1325	13	4	the	the	DET
dti-1325	13	5	active	active	ADJ
dti-1325	13	6	complex	complex	ADJ
dti-1325	13	7	formation	formation	NOUN
dti-1325	13	8	and	and	CCONJ
dti-1325	13	9	thereby	thereby	ADV
dti-1325	13	10	inhibits	inhibit	VERB
dti-1325	13	11	the	the	DET
dti-1325	13	12	binding	binding	NOUN
dti-1325	13	13	of	of	ADP
dti-1325	13	14	fitc	fitc	NOUN
dti-1325	13	15	-	-	PUNCT
dti-1325	13	16	pac-1	pac-1	NOUN
dti-1325	13	17	in	in	ADP
dti-1325	13	18	a	a	DET
dti-1325	13	19	dose	dose	ADJ
dti-1325	13	20	dependent	dependent	ADJ
dti-1325	13	21	manner	manner	NOUN
dti-1325	13	22	by	by	ADP
dti-1325	13	23	fl	fl	NUM
dti-1325	13	24	ow	ow	PROPN
dti-1325	13	25	cytometric	cytometric	ADJ
dti-1325	13	26	analyses	analysis	NOUN
dti-1325	13	27	,	,	PUNCT
dti-1325	13	28	as	as	ADV
dti-1325	13	29	well	well	ADV
dti-1325	13	30	as	as	ADP
dti-1325	13	31	binding	bind	VERB
dti-1325	13	32	of	of	ADP
dti-1325	13	33	[	[	X
dti-1325	13	34	3h]-fi	3h]-fi	NUM
dti-1325	13	35	brinogen	brinogen	NOUN
dti-1325	13	36	.	.	PUNCT
dti-1325	14	1	in	in	ADP
dti-1325	14	2	addition	addition	NOUN
dti-1325	14	3	,	,	PUNCT
dti-1325	14	4	creation	creation	NOUN
dti-1325	14	5	of	of	ADP
dti-1325	14	6	a	a	DET
dti-1325	14	7	second	second	ADJ
dti-1325	14	8	stable	stable	ADJ
dti-1325	14	9	cell	cell	NOUN
dti-1325	14	10	line	line	NOUN
dti-1325	14	11	containing	contain	VERB
dti-1325	14	12	wild	wild	ADJ
dti-1325	14	13	type	type	NOUN
dti-1325	14	14	αiib	αiib	NOUN
dti-1325	14	15	and	and	CCONJ
dti-1325	14	16	the	the	DET
dti-1325	14	17	mutated	mutate	VERB
dti-1325	14	18	region	region	NOUN
dti-1325	14	19	of	of	ADP
dti-1325	14	20	β3	β3	PROPN
dti-1325	14	21	(	(	PUNCT
dti-1325	14	22	residues	residue	NOUN
dti-1325	14	23	499–513	499–513	NUM
dti-1325	14	24	)	)	PUNCT
dti-1325	14	25	shows	show	VERB
dti-1325	14	26	that	that	SCONJ
dti-1325	14	27	the	the	DET
dti-1325	14	28	binding	binding	NOUN
dti-1325	14	29	of	of	ADP
dti-1325	14	30	fitc	fitc	NOUN
dti-1325	14	31	-	-	PUNCT
dti-1325	14	32	pac-1	pac-1	NOUN
dti-1325	14	33	and	and	CCONJ
dti-1325	14	34	[	[	X
dti-1325	14	35	3h]-fi	3h]-fi	NUM
dti-1325	14	36	brinogen	brinogen	NOUN
dti-1325	14	37	on	on	ADP
dti-1325	14	38	the	the	DET
dti-1325	14	39	mutant	mutant	ADJ
dti-1325	14	40	activated	activate	VERB
dti-1325	14	41	complex	complex	NOUN
dti-1325	14	42	was	be	AUX
dti-1325	14	43	much	much	ADV
dti-1325	14	44	lower	low	ADJ
dti-1325	14	45	than	than	ADP
dti-1325	14	46	the	the	DET
dti-1325	14	47	wild	wild	ADJ
dti-1325	14	48	type	type	NOUN
dti-1325	14	49	activated	activate	VERB
dti-1325	14	50	complex	complex	NOUN
dti-1325	14	51	.	.	PUNCT
dti-1325	15	1	our	our	PRON
dti-1325	15	2	results	result	NOUN
dti-1325	15	3	indicate	indicate	VERB
dti-1325	15	4	that	that	SCONJ
dti-1325	15	5	the	the	DET
dti-1325	15	6	region	region	NOUN
dti-1325	15	7	499–513	499–513	PROPN
dti-1325	15	8	in	in	ADP
dti-1325	15	9	β3	β3	PROPN
dti-1325	15	10	is	be	AUX
dti-1325	15	11	one	one	NUM
dti-1325	15	12	of	of	ADP
dti-1325	15	13	the	the	DET
dti-1325	15	14	important	important	ADJ
dti-1325	15	15	sites	site	NOUN
dti-1325	15	16	for	for	ADP
dti-1325	15	17	αiib	αiib	ADJ
dti-1325	15	18	/	/	SYM
dti-1325	15	19	β3	β3	ADJ
dti-1325	15	20	active	active	ADJ
dti-1325	15	21	complex	complex	ADJ
dti-1325	15	22	formation	formation	NOUN
dti-1325	15	23	and	and	CCONJ
dti-1325	15	24	the	the	DET
dti-1325	15	25	cysteines	cysteine	NOUN
dti-1325	15	26	play	play	VERB
dti-1325	15	27	an	an	DET
dti-1325	15	28	important	important	ADJ
dti-1325	15	29	role	role	NOUN
dti-1325	15	30	in	in	ADP
dti-1325	15	31	the	the	DET
dti-1325	15	32	process	process	NOUN
dti-1325	15	33	.	.	PUNCT
dti-1325	16	1	keywords	keyword	NOUN
dti-1325	16	2	:	:	PUNCT
dti-1325	16	3	α2ß3	α2ß3	PUNCT
dti-1325	16	4	integrin	integrin	NOUN
dti-1325	16	5	,	,	PUNCT
dti-1325	16	6	fl	fl	INTJ
dti-1325	16	7	ow	ow	PROPN
dti-1325	16	8	cytometry	cytometry	PROPN
dti-1325	16	9	,	,	PUNCT
dti-1325	16	10	disulphide	disulphide	ADV
dti-1325	16	11	bond	bond	NOUN
dti-1325	16	12	,	,	PUNCT
dti-1325	16	13	fi	fi	NOUN
dti-1325	16	14	brinogen	brinogen	PROPN
dti-1325	16	15	,	,	PUNCT
dti-1325	16	16	integrin	integrin	NOUN
dti-1325	16	17	activation	activation	NOUN
dti-1325	16	18	,	,	PUNCT
dti-1325	16	19	mutagenesis	mutagenesis	NOUN
dti-1325	16	20	introduction	introduction	NOUN
dti-1325	16	21	alphaiibbeta3	alphaiibbeta3	NOUN
dti-1325	16	22	(	(	PUNCT
dti-1325	16	23	αiib	αiib	NOUN
dti-1325	16	24	/	/	SYM
dti-1325	16	25	β3	β3	ADJ
dti-1325	16	26	)	)	PUNCT
dti-1325	16	27	complex	complex	NOUN
dti-1325	16	28	plays	play	VERB
dti-1325	16	29	an	an	DET
dti-1325	16	30	important	important	ADJ
dti-1325	16	31	role	role	NOUN
dti-1325	16	32	in	in	ADP
dti-1325	16	33	platelet	platelet	NOUN
dti-1325	16	34	aggregation	aggregation	NOUN
dti-1325	16	35	.	.	PUNCT
dti-1325	17	1	the	the	DET
dti-1325	17	2	αiib	αiib	ADJ
dti-1325	17	3	/	/	SYM
dti-1325	17	4	β3	β3	ADJ
dti-1325	17	5	complex	complex	ADJ
dti-1325	17	6	exists	exist	VERB
dti-1325	17	7	in	in	ADP
dti-1325	17	8	the	the	DET
dti-1325	17	9	inactive	inactive	ADJ
dti-1325	17	10	and	and	CCONJ
dti-1325	17	11	active	active	ADJ
dti-1325	17	12	conformational	conformational	ADJ
dti-1325	17	13	states	state	NOUN
dti-1325	17	14	.	.	PUNCT
dti-1325	18	1	the	the	DET
dti-1325	18	2	activated	activate	VERB
dti-1325	18	3	complex	complex	NOUN
dti-1325	18	4	serves	serve	VERB
dti-1325	18	5	as	as	ADP
dti-1325	18	6	ligand	ligand	NOUN
dti-1325	18	7	-	-	PUNCT
dti-1325	18	8	binding	bind	VERB
dti-1325	18	9	sites	site	NOUN
dti-1325	18	10	(	(	PUNCT
dti-1325	18	11	luo	luo	PROPN
dti-1325	18	12	et	et	PROPN
dti-1325	18	13	al	al	PROPN
dti-1325	18	14	.	.	PROPN
dti-1325	18	15	2004	2004	NUM
dti-1325	18	16	;	;	PUNCT
dti-1325	18	17	schwartz	schwartz	PROPN
dti-1325	18	18	et	et	PROPN
dti-1325	18	19	al	al	PROPN
dti-1325	18	20	.	.	PROPN
dti-1325	18	21	1995	1995	NUM
dti-1325	18	22	)	)	PUNCT
dti-1325	18	23	for	for	ADP
dti-1325	18	24	four	four	NUM
dti-1325	18	25	macromolecules	macromolecule	NOUN
dti-1325	18	26	(	(	PUNCT
dti-1325	18	27	fi	fi	NOUN
dti-1325	18	28	brinogen	brinogen	PROPN
dti-1325	18	29	,	,	PUNCT
dti-1325	18	30	von	von	PROPN
dti-1325	18	31	willebrand	willebrand	NOUN
dti-1325	18	32	factor	factor	NOUN
dti-1325	18	33	,	,	PUNCT
dti-1325	18	34	fi	fi	NOUN
dti-1325	18	35	bronectin	bronectin	NOUN
dti-1325	18	36	and	and	CCONJ
dti-1325	18	37	vitronectin	vitronectin	NOUN
dti-1325	18	38	)	)	PUNCT
dti-1325	18	39	.	.	PUNCT
dti-1325	19	1	the	the	DET
dti-1325	19	2	binding	binding	NOUN
dti-1325	19	3	of	of	ADP
dti-1325	19	4	fi	fi	NOUN
dti-1325	19	5	brinogen	brinogen	NOUN
dti-1325	19	6	to	to	ADP
dti-1325	19	7	the	the	DET
dti-1325	19	8	activated	activate	VERB
dti-1325	19	9	αiib	αiib	ADJ
dti-1325	19	10	/	/	SYM
dti-1325	19	11	β3	β3	ADJ
dti-1325	19	12	complex	complex	ADJ
dti-1325	19	13	mediates	mediate	NOUN
dti-1325	19	14	the	the	DET
dti-1325	19	15	fi	fi	NOUN
dti-1325	19	16	nal	nal	ADJ
dti-1325	19	17	step	step	NOUN
dti-1325	19	18	of	of	ADP
dti-1325	19	19	platelet	platelet	NOUN
dti-1325	19	20	aggregation	aggregation	NOUN
dti-1325	19	21	.	.	PUNCT
dti-1325	20	1	in	in	ADP
dti-1325	20	2	damaged	damage	VERB
dti-1325	20	3	vessel	vessel	NOUN
dti-1325	20	4	walls	wall	NOUN
dti-1325	20	5	,	,	PUNCT
dti-1325	20	6	αiib	αiib	ADJ
dti-1325	20	7	/	/	SYM
dti-1325	20	8	β3	β3	PROPN
dti-1325	20	9	undergoes	undergo	VERB
dti-1325	20	10	a	a	DET
dti-1325	20	11	conformational	conformational	ADJ
dti-1325	20	12	change	change	NOUN
dti-1325	20	13	from	from	ADP
dti-1325	20	14	an	an	DET
dti-1325	20	15	inactive	inactive	NOUN
dti-1325	20	16	to	to	ADP
dti-1325	20	17	an	an	DET
dti-1325	20	18	active	active	ADJ
dti-1325	20	19	state	state	NOUN
dti-1325	20	20	that	that	PRON
dti-1325	20	21	is	be	AUX
dti-1325	20	22	able	able	ADJ
dti-1325	20	23	to	to	PART
dti-1325	20	24	initiate	initiate	VERB
dti-1325	20	25	thrombi	thrombi	NOUN
dti-1325	20	26	formation	formation	NOUN
dti-1325	20	27	.	.	PUNCT
dti-1325	21	1	many	many	ADJ
dti-1325	21	2	studies	study	NOUN
dti-1325	21	3	have	have	AUX
dti-1325	21	4	proposed	propose	VERB
dti-1325	21	5	that	that	SCONJ
dti-1325	21	6	the	the	DET
dti-1325	21	7	interaction	interaction	NOUN
dti-1325	21	8	between	between	ADP
dti-1325	21	9	αiib	αiib	NOUN
dti-1325	21	10	and	and	CCONJ
dti-1325	21	11	β3	β3	AUX
dti-1325	21	12	reside	reside	VERB
dti-1325	21	13	in	in	ADP
dti-1325	21	14	several	several	ADJ
dti-1325	21	15	regions	region	NOUN
dti-1325	21	16	(	(	PUNCT
dti-1325	21	17	filizola	filizola	PROPN
dti-1325	21	18	et	et	PROPN
dti-1325	21	19	al	al	PROPN
dti-1325	21	20	.	.	PROPN
dti-1325	21	21	2004	2004	NUM
dti-1325	21	22	;	;	PUNCT
dti-1325	21	23	feuston	feuston	NOUN
dti-1325	21	24	,	,	PUNCT
dti-1325	21	25	2003	2003	NUM
dti-1325	21	26	and	and	CCONJ
dti-1325	21	27	d’souza	d’souza	PROPN
dti-1325	21	28	et	et	PROPN
dti-1325	21	29	al	al	PROPN
dti-1325	21	30	.	.	PROPN
dti-1325	21	31	1994	1994	NUM
dti-1325	21	32	)	)	PUNCT
dti-1325	21	33	.	.	PUNCT
dti-1325	22	1	there	there	PRON
dti-1325	22	2	are	be	VERB
dti-1325	22	3	two	two	NUM
dti-1325	22	4	discrete	discrete	ADJ
dti-1325	22	5	peptides	peptide	NOUN
dti-1325	22	6	defi	defi	NOUN
dti-1325	22	7	ned	ne	VERB
dti-1325	22	8	from	from	ADP
dti-1325	22	9	β3	β3	NOUN
dti-1325	22	10	with	with	ADP
dti-1325	22	11	amino	amino	NOUN
dti-1325	22	12	acid	acid	NOUN
dti-1325	22	13	residues	residue	NOUN
dti-1325	22	14	of	of	ADP
dti-1325	22	15	211–222	211–222	NUM
dti-1325	22	16	and	and	CCONJ
dti-1325	22	17	217–230	217–230	NUM
dti-1325	22	18	,	,	PUNCT
dti-1325	22	19	which	which	PRON
dti-1325	22	20	have	have	AUX
dti-1325	22	21	been	be	AUX
dti-1325	22	22	reported	report	VERB
dti-1325	22	23	to	to	PART
dti-1325	22	24	inhibit	inhibit	VERB
dti-1325	22	25	fi	fi	NOUN
dti-1325	22	26	brinogen	brinogen	NOUN
dti-1325	22	27	binding	bind	VERB
dti-1325	22	28	and	and	CCONJ
dti-1325	22	29	affect	affect	VERB
dti-1325	22	30	platelet	platelet	NOUN
dti-1325	22	31	aggregation	aggregation	NOUN
dti-1325	22	32	(	(	PUNCT
dti-1325	22	33	charo	charo	PROPN
dti-1325	22	34	et	et	PROPN
dti-1325	22	35	al	al	PROPN
dti-1325	22	36	.	.	PROPN
dti-1325	22	37	1991	1991	NUM
dti-1325	22	38	and	and	CCONJ
dti-1325	22	39	steiner	steiner	PROPN
dti-1325	22	40	et	et	PROPN
dti-1325	22	41	al	al	PROPN
dti-1325	22	42	.	.	PROPN
dti-1325	22	43	1993	1993	NUM
dti-1325	22	44	)	)	PUNCT
dti-1325	22	45	.	.	PUNCT
dti-1325	23	1	in	in	ADP
dti-1325	23	2	addition	addition	NOUN
dti-1325	23	3	,	,	PUNCT
dti-1325	23	4	two	two	NUM
dti-1325	23	5	complex	complex	ADJ
dti-1325	23	6	forming	form	VERB
dti-1325	23	7	sequences	sequence	NOUN
dti-1325	23	8	of	of	ADP
dti-1325	23	9	αiib	αiib	NOUN
dti-1325	23	10	and	and	CCONJ
dti-1325	23	11	β3	β3	ADJ
dti-1325	23	12	(	(	PUNCT
dti-1325	23	13	αiib	αiib	NOUN
dti-1325	23	14	:	:	PUNCT
dti-1325	23	15	94–314	94–314	NUM
dti-1325	23	16	and	and	CCONJ
dti-1325	23	17	ß3	ß3	NOUN
dti-1325	23	18	:	:	PUNCT
dti-1325	23	19	118–131	118–131	NUM
dti-1325	23	20	,	,	PUNCT
dti-1325	23	21	and	and	CCONJ
dti-1325	23	22	αiib	αiib	NOUN
dti-1325	23	23	:	:	PUNCT
dti-1325	23	24	e117	e117	NUM
dti-1325	23	25	and	and	CCONJ
dti-1325	23	26	β3	β3	ADJ
dti-1325	23	27	:	:	PUNCT
dti-1325	23	28	r214	r214	NUM
dti-1325	23	29	)	)	PUNCT
dti-1325	23	30	,	,	PUNCT
dti-1325	23	31	which	which	PRON
dti-1325	23	32	correlate	correlate	VERB
dti-1325	23	33	with	with	ADP
dti-1325	23	34	both	both	CCONJ
dti-1325	23	35	ligand	ligand	ADJ
dti-1325	23	36	and	and	CCONJ
dti-1325	23	37	cation	cation	NOUN
dti-1325	23	38	binding	bind	VERB
dti-1325	23	39	within	within	ADP
dti-1325	23	40	the	the	DET
dti-1325	23	41	αiib	αiib	ADJ
dti-1325	23	42	/	/	SYM
dti-1325	23	43	β3	β3	NOUN
dti-1325	23	44	complex	complex	NOUN
dti-1325	23	45	,	,	PUNCT
dti-1325	23	46	have	have	AUX
dti-1325	23	47	been	be	AUX
dti-1325	23	48	identifi	identifi	PROPN
dti-1325	23	49	ed	ed	PROPN
dti-1325	23	50	(	(	PUNCT
dti-1325	23	51	feuston	feuston	NOUN
dti-1325	23	52	,	,	PUNCT
dti-1325	23	53	2003	2003	NUM
dti-1325	23	54	;	;	PUNCT
dti-1325	23	55	d’souza	d’souza	PROPN
dti-1325	23	56	et	et	PROPN
dti-1325	23	57	al	al	PROPN
dti-1325	23	58	.	.	PROPN
dti-1325	23	59	1994	1994	NUM
dti-1325	23	60	;	;	PUNCT
dti-1325	23	61	d’souza	d’souza	PROPN
dti-1325	23	62	et	et	PROPN
dti-1325	23	63	al	al	PROPN
dti-1325	23	64	.	.	PROPN
dti-1325	23	65	1991	1991	NUM
dti-1325	23	66	and	and	CCONJ
dti-1325	23	67	charo	charo	PROPN
dti-1325	23	68	et	et	PROPN
dti-1325	23	69	al	al	PROPN
dti-1325	23	70	.	.	PROPN
dti-1325	23	71	1991	1991	NUM
dti-1325	23	72	)	)	PUNCT
dti-1325	23	73	.	.	PUNCT
dti-1325	24	1	other	other	ADJ
dti-1325	24	2	investigators	investigator	NOUN
dti-1325	24	3	(	(	PUNCT
dti-1325	24	4	kashiwagi	kashiwagi	PROPN
dti-1325	24	5	et	et	PROPN
dti-1325	24	6	al	al	PROPN
dti-1325	24	7	.	.	PROPN
dti-1325	24	8	1999	1999	NUM
dti-1325	24	9	;	;	PUNCT
dti-1325	24	10	sun	sun	PROPN
dti-1325	24	11	et	et	PROPN
dti-1325	24	12	al	al	PROPN
dti-1325	24	13	.	.	PROPN
dti-1325	24	14	2002	2002	NUM
dti-1325	24	15	;	;	PUNCT
dti-1325	24	16	beglova	beglova	PROPN
dti-1325	24	17	et	et	PROPN
dti-1325	24	18	al	al	PROPN
dti-1325	24	19	.	.	PROPN
dti-1325	24	20	2002	2002	NUM
dti-1325	24	21	and	and	CCONJ
dti-1325	24	22	butta	butta	NOUN
dti-1325	24	23	et	et	PROPN
dti-1325	24	24	al	al	PROPN
dti-1325	24	25	.	.	PROPN
dti-1325	24	26	2003	2003	NUM
dti-1325	24	27	)	)	PUNCT
dti-1325	24	28	have	have	AUX
dti-1325	24	29	addressed	address	VERB
dti-1325	24	30	the	the	DET
dti-1325	24	31	important	important	ADJ
dti-1325	24	32	function	function	NOUN
dti-1325	24	33	of	of	ADP
dti-1325	24	34	cysteine	cysteine	NOUN
dti-1325	24	35	residues	residue	NOUN
dti-1325	24	36	in	in	ADP
dti-1325	24	37	β3	β3	ADJ
dti-1325	24	38	.	.	PUNCT
dti-1325	25	1	the	the	DET
dti-1325	25	2	consensus	consensus	NOUN
dti-1325	25	3	is	be	AUX
dti-1325	25	4	that	that	SCONJ
dti-1325	25	5	cysteine	cysteine	NOUN
dti-1325	25	6	residues	residue	NOUN
dti-1325	25	7	play	play	VERB
dti-1325	25	8	an	an	DET
dti-1325	25	9	important	important	ADJ
dti-1325	25	10	role	role	NOUN
dti-1325	25	11	in	in	ADP
dti-1325	25	12	the	the	DET
dti-1325	25	13	formation	formation	NOUN
dti-1325	25	14	of	of	ADP
dti-1325	25	15	the	the	DET
dti-1325	25	16	active	active	ADJ
dti-1325	25	17	complex	complex	NOUN
dti-1325	25	18	.	.	PUNCT
dti-1325	26	1	wang	wang	PROPN
dti-1325	26	2	et	et	PROPN
dti-1325	26	3	al	al	PROPN
dti-1325	26	4	.	.	PROPN
dti-1325	26	5	(	(	PUNCT
dti-1325	26	6	1997	1997	NUM
dti-1325	26	7	)	)	PUNCT
dti-1325	26	8	have	have	AUX
dti-1325	26	9	found	find	VERB
dti-1325	26	10	that	that	SCONJ
dti-1325	26	11	disruption	disruption	NOUN
dti-1325	26	12	of	of	ADP
dti-1325	26	13	the	the	DET
dti-1325	26	14	disulfi	disulfi	PROPN
dti-1325	26	15	de	de	X
dti-1325	26	16	bond	bond	NOUN
dti-1325	26	17	between	between	ADP
dti-1325	26	18	cys	cys	PROPN
dti-1325	26	19	406	406	NUM
dti-1325	26	20	and	and	CCONJ
dti-1325	26	21	cys	cys	PROPN
dti-1325	26	22	665	665	NUM
dti-1325	26	23	of	of	ADP
dti-1325	26	24	β3	β3	ADJ
dti-1325	26	25	did	do	AUX
dti-1325	26	26	not	not	PART
dti-1325	26	27	affect	affect	VERB
dti-1325	26	28	αiib	αiib	ADJ
dti-1325	26	29	/	/	SYM
dti-1325	26	30	β3	β3	ADJ
dti-1325	26	31	ligand	ligand	NOUN
dti-1325	26	32	binding	binding	NOUN
dti-1325	26	33	.	.	PUNCT
dti-1325	27	1	however	however	ADV
dti-1325	27	2	,	,	PUNCT
dti-1325	27	3	in	in	ADP
dti-1325	27	4	some	some	DET
dti-1325	27	5	cases	case	NOUN
dti-1325	27	6	,	,	PUNCT
dti-1325	27	7	disruption	disruption	NOUN
dti-1325	27	8	of	of	ADP
dti-1325	27	9	certain	certain	ADJ
dti-1325	27	10	disulfi	disulfi	NOUN
dti-1325	27	11	de	de	X
dti-1325	27	12	bonds	bond	NOUN
dti-1325	27	13	resulted	result	VERB
dti-1325	27	14	in	in	ADP
dti-1325	27	15	the	the	DET
dti-1325	27	16	formation	formation	NOUN
dti-1325	27	17	of	of	ADP
dti-1325	27	18	an	an	DET
dti-1325	27	19	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1325	27	20	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1325	27	21	68	68	NUM
dti-1325	27	22	woo	woo	NOUN
dti-1325	27	23	-	-	PUNCT
dti-1325	27	24	rasberry	rasberry	NOUN
dti-1325	27	25	and	and	CCONJ
dti-1325	27	26	chiang	chiang	PROPN
dti-1325	27	27	drug	drug	PROPN
dti-1325	27	28	target	target	NOUN
dti-1325	27	29	insights	insight	VERB
dti-1325	27	30	2008:3	2008:3	NUM
dti-1325	27	31	active	active	ADJ
dti-1325	27	32	complex	complex	NOUN
dti-1325	27	33	.	.	PUNCT
dti-1325	27	34	kashiwagi	kashiwagi	PROPN
dti-1325	27	35	et	et	PROPN
dti-1325	27	36	al	al	PROPN
dti-1325	27	37	.	.	PROPN
dti-1325	28	1	(	(	PUNCT
dti-1325	28	2	1999	1999	NUM
dti-1325	28	3	)	)	PUNCT
dti-1325	28	4	created	create	VERB
dti-1325	28	5	a	a	DET
dti-1325	28	6	single	single	ADJ
dti-1325	28	7	amino	amino	NOUN
dti-1325	28	8	acid	acid	NOUN
dti-1325	28	9	mutation	mutation	NOUN
dti-1325	28	10	in	in	ADP
dti-1325	28	11	the	the	DET
dti-1325	28	12	extracellular	extracellular	ADJ
dti-1325	28	13	cysteine	cysteine	NOUN
dti-1325	28	14	-	-	PUNCT
dti-1325	28	15	rich	rich	ADJ
dti-1325	28	16	repeat	repeat	NOUN
dti-1325	28	17	region	region	NOUN
dti-1325	28	18	of	of	ADP
dti-1325	28	19	the	the	DET
dti-1325	28	20	β3	β3	ADJ
dti-1325	28	21	subunit	subunit	NOUN
dti-1325	28	22	(	(	PUNCT
dti-1325	28	23	t562n	t562n	NUM
dti-1325	28	24	)	)	PUNCT
dti-1325	28	25	,	,	PUNCT
dti-1325	28	26	and	and	CCONJ
dti-1325	28	27	activated	activate	VERB
dti-1325	28	28	αiib	αiib	NOUN
dti-1325	28	29	/	/	SYM
dti-1325	28	30	β3	β3	ADJ
dti-1325	28	31	.	.	PUNCT
dti-1325	29	1	although	although	SCONJ
dti-1325	29	2	,	,	PUNCT
dti-1325	29	3	many	many	ADJ
dti-1325	29	4	laboratories	laboratory	NOUN
dti-1325	29	5	have	have	AUX
dti-1325	29	6	studied	study	VERB
dti-1325	29	7	the	the	DET
dti-1325	29	8	extracellular	extracellular	ADJ
dti-1325	29	9	,	,	PUNCT
dti-1325	29	10	transmembrane	transmembrane	NOUN
dti-1325	29	11	,	,	PUNCT
dti-1325	29	12	cytoplasmic	cytoplasmic	ADJ
dti-1325	29	13	regions	region	NOUN
dti-1325	29	14	and	and	CCONJ
dti-1325	29	15	carboxylterminal	carboxylterminal	ADJ
dti-1325	29	16	of	of	ADP
dti-1325	29	17	β3	β3	ADJ
dti-1325	29	18	in	in	ADP
dti-1325	29	19	relation	relation	NOUN
dti-1325	29	20	to	to	ADP
dti-1325	29	21	the	the	DET
dti-1325	29	22	formation	formation	NOUN
dti-1325	29	23	of	of	ADP
dti-1325	29	24	the	the	DET
dti-1325	29	25	functional	functional	ADJ
dti-1325	29	26	complex	complex	NOUN
dti-1325	29	27	,	,	PUNCT
dti-1325	29	28	the	the	DET
dti-1325	29	29	exact	exact	ADJ
dti-1325	29	30	site	site	NOUN
dti-1325	29	31	remains	remain	VERB
dti-1325	29	32	to	to	PART
dti-1325	29	33	be	be	AUX
dti-1325	29	34	determined	determine	VERB
dti-1325	29	35	.	.	PUNCT
dti-1325	30	1	previously	previously	ADV
dti-1325	30	2	,	,	PUNCT
dti-1325	30	3	we	we	PRON
dti-1325	30	4	have	have	AUX
dti-1325	30	5	reported	report	VERB
dti-1325	30	6	that	that	SCONJ
dti-1325	30	7	a	a	DET
dti-1325	30	8	platelet	platelet	NOUN
dti-1325	30	9	90	90	NUM
dti-1325	30	10	-	-	PUNCT
dti-1325	30	11	kda	kda	NOUN
dti-1325	30	12	glycoprotein	glycoprotein	NOUN
dti-1325	30	13	(	(	PUNCT
dti-1325	30	14	gp	gp	NOUN
dti-1325	30	15	90	90	NUM
dti-1325	30	16	)	)	PUNCT
dti-1325	30	17	is	be	AUX
dti-1325	30	18	involved	involve	VERB
dti-1325	30	19	in	in	ADP
dti-1325	30	20	collagen-	collagen-	INTJ
dti-1325	30	21	,	,	PUNCT
dti-1325	30	22	epinephrine-	epinephrine-	X
dti-1325	30	23	,	,	PUNCT
dti-1325	30	24	and	and	CCONJ
dti-1325	30	25	thrombin	thrombin	NOUN
dti-1325	30	26	-	-	PUNCT
dti-1325	30	27	platelet	platelet	NOUN
dti-1325	30	28	interaction	interaction	NOUN
dti-1325	30	29	(	(	PUNCT
dti-1325	30	30	chiang	chiang	PROPN
dti-1325	30	31	et	et	PROPN
dti-1325	30	32	al	al	PROPN
dti-1325	30	33	.	.	PROPN
dti-1325	30	34	1989	1989	NUM
dti-1325	30	35	)	)	PUNCT
dti-1325	30	36	.	.	PUNCT
dti-1325	31	1	we	we	PRON
dti-1325	31	2	have	have	AUX
dti-1325	31	3	identified	identify	VERB
dti-1325	31	4	the	the	DET
dti-1325	31	5	protein	protein	NOUN
dti-1325	31	6	as	as	SCONJ
dti-1325	31	7	β3	β3	ADJ
dti-1325	31	8	by	by	ADP
dti-1325	31	9	using	use	VERB
dti-1325	31	10	twodimensional	twodimensional	ADJ
dti-1325	31	11	gel	gel	NOUN
dti-1325	31	12	(	(	PUNCT
dti-1325	31	13	2d	2d	NOUN
dti-1325	31	14	gel	gel	NOUN
dti-1325	31	15	)	)	PUNCT
dti-1325	31	16	electrophoresis	electrophoresis	NOUN
dti-1325	31	17	,	,	PUNCT
dti-1325	31	18	immunblotted	immunblotte	VERB
dti-1325	31	19	with	with	ADP
dti-1325	31	20	anti-90	anti-90	NOUN
dti-1325	31	21	-	-	PUNCT
dti-1325	31	22	kda	kda	NOUN
dti-1325	31	23	and	and	CCONJ
dti-1325	31	24	anti	anti	ADJ
dti-1325	31	25	-	-	ADJ
dti-1325	31	26	β3	β3	ADJ
dti-1325	31	27	antibodies	antibody	NOUN
dti-1325	31	28	,	,	PUNCT
dti-1325	31	29	and	and	CCONJ
dti-1325	31	30	matrix	matrix	NOUN
dti-1325	31	31	assisted	assist	VERB
dti-1325	31	32	laser	laser	NOUN
dti-1325	31	33	desorption/	desorption/	NUM
dti-1325	31	34	ionization	ionization	NOUN
dti-1325	31	35	-	-	PUNCT
dti-1325	31	36	time	time	NOUN
dti-1325	31	37	of	of	ADP
dti-1325	31	38	flight	flight	NOUN
dti-1325	31	39	(	(	PUNCT
dti-1325	31	40	maldi	maldi	NOUN
dti-1325	31	41	-	-	PUNCT
dti-1325	31	42	tof	tof	PROPN
dti-1325	31	43	)	)	PUNCT
dti-1325	31	44	.	.	PUNCT
dti-1325	32	1	searches	search	NOUN
dti-1325	32	2	of	of	ADP
dti-1325	32	3	the	the	DET
dti-1325	32	4	swiss	swiss	ADJ
dti-1325	32	5	-	-	PUNCT
dti-1325	32	6	prot	prot	NOUN
dti-1325	32	7	database	database	NOUN
dti-1325	32	8	for	for	ADP
dti-1325	32	9	the	the	DET
dti-1325	32	10	identity	identity	NOUN
dti-1325	32	11	with	with	ADP
dti-1325	32	12	the	the	DET
dti-1325	32	13	mass	mass	ADJ
dti-1325	32	14	spectra	spectra	NOUN
dti-1325	32	15	of	of	ADP
dti-1325	32	16	the	the	DET
dti-1325	32	17	trypsinized	trypsinize	VERB
dti-1325	32	18	fragments	fragment	NOUN
dti-1325	32	19	,	,	PUNCT
dti-1325	32	20	isoelectric	isoelectric	ADJ
dti-1325	32	21	point	point	NOUN
dti-1325	32	22	,	,	PUNCT
dti-1325	32	23	and	and	CCONJ
dti-1325	32	24	molecular	molecular	ADJ
dti-1325	32	25	weight	weight	NOUN
dti-1325	32	26	resulted	result	VERB
dti-1325	32	27	in	in	ADP
dti-1325	32	28	a	a	DET
dti-1325	32	29	match	match	NOUN
dti-1325	32	30	with	with	ADP
dti-1325	32	31	human	human	ADJ
dti-1325	32	32	platelet	platelet	NOUN
dti-1325	32	33	β3	β3	PROPN
dti-1325	32	34	.	.	PUNCT
dti-1325	33	1	recently	recently	ADV
dti-1325	33	2	,	,	PUNCT
dti-1325	33	3	we	we	PRON
dti-1325	33	4	have	have	VERB
dti-1325	33	5	defi	defi	NOUN
dti-1325	33	6	ned	ned	DET
dti-1325	33	7	a	a	DET
dti-1325	33	8	region	region	NOUN
dti-1325	33	9	of	of	ADP
dti-1325	33	10	β3	β3	PROPN
dti-1325	33	11	(	(	PUNCT
dti-1325	33	12	residues	residue	NOUN
dti-1325	33	13	499–513	499–513	NUM
dti-1325	33	14	,	,	PUNCT
dti-1325	33	15	named	name	VERB
dti-1325	33	16	p4	p4	ADJ
dti-1325	33	17	)	)	PUNCT
dti-1325	33	18	,	,	PUNCT
dti-1325	33	19	which	which	PRON
dti-1325	33	20	inhibits	inhibit	VERB
dti-1325	33	21	antagonists	antagonist	NOUN
dti-1325	33	22	-	-	PUNCT
dti-1325	33	23	induced	induce	VERB
dti-1325	33	24	platelet	platelet	NOUN
dti-1325	33	25	activation	activation	NOUN
dti-1325	33	26	by	by	ADP
dti-1325	33	27	inhibiting	inhibit	VERB
dti-1325	33	28	fitc	fitc	NOUN
dti-1325	33	29	-	-	PUNCT
dti-1325	33	30	pac-1	pac-1	NOUN
dti-1325	33	31	binding	binding	NOUN
dti-1325	33	32	.	.	PUNCT
dti-1325	34	1	a	a	DET
dti-1325	34	2	chemically	chemically	ADV
dti-1325	34	3	synthesized	synthesize	VERB
dti-1325	34	4	peptide	peptide	NOUN
dti-1325	34	5	also	also	ADV
dti-1325	34	6	inhibits	inhibit	VERB
dti-1325	34	7	adp-	adp-	NOUN
dti-1325	34	8	,	,	PUNCT
dti-1325	34	9	type	type	VERB
dti-1325	34	10	i	i	PRON
dti-1325	34	11	collagenand	collagenand	VERB
dti-1325	34	12	type	type	NOUN
dti-1325	34	13	iii	iii	NUM
dti-1325	34	14	collagen	collagen	NOUN
dti-1325	34	15	-	-	PUNCT
dti-1325	34	16	induced	induce	VERB
dti-1325	34	17	platelet	platelet	NOUN
dti-1325	34	18	aggregation	aggregation	NOUN
dti-1325	34	19	in	in	ADP
dti-1325	34	20	a	a	DET
dti-1325	34	21	dose	dose	NOUN
dti-1325	34	22	-	-	PUNCT
dti-1325	34	23	dependent	dependent	ADJ
dti-1325	34	24	manner	manner	NOUN
dti-1325	34	25	through	through	ADP
dti-1325	34	26	the	the	DET
dti-1325	34	27	inhibition	inhibition	NOUN
dti-1325	34	28	of	of	ADP
dti-1325	34	29	αiib	αiib	ADJ
dti-1325	34	30	/	/	SYM
dti-1325	34	31	β3	β3	ADJ
dti-1325	34	32	complex	complex	ADJ
dti-1325	34	33	formation	formation	NOUN
dti-1325	34	34	(	(	PUNCT
dti-1325	34	35	chiang	chiang	PROPN
dti-1325	34	36	et	et	PROPN
dti-1325	34	37	al	al	PROPN
dti-1325	34	38	.	.	PROPN
dti-1325	34	39	2005	2005	NUM
dti-1325	34	40	)	)	PUNCT
dti-1325	34	41	.	.	PUNCT
dti-1325	35	1	in	in	ADP
dti-1325	35	2	the	the	DET
dti-1325	35	3	present	present	ADJ
dti-1325	35	4	study	study	NOUN
dti-1325	35	5	,	,	PUNCT
dti-1325	35	6	we	we	PRON
dti-1325	35	7	have	have	AUX
dti-1325	35	8	constructed	construct	VERB
dti-1325	35	9	three	three	NUM
dti-1325	35	10	mutant	mutant	ADJ
dti-1325	35	11	cdnas	cdna	NOUN
dti-1325	35	12	of	of	ADP
dti-1325	35	13	β3	β3	ADJ
dti-1325	35	14	by	by	ADP
dti-1325	35	15	scrambling	scramble	VERB
dti-1325	35	16	the	the	DET
dti-1325	35	17	amino	amino	NOUN
dti-1325	35	18	acid	acid	NOUN
dti-1325	35	19	residues	residue	NOUN
dti-1325	35	20	and	and	CCONJ
dti-1325	35	21	the	the	DET
dti-1325	35	22	other	other	ADJ
dti-1325	35	23	two	two	NUM
dti-1325	35	24	by	by	ADP
dti-1325	35	25	substituting	substitute	VERB
dti-1325	35	26	the	the	DET
dti-1325	35	27	cysteine	cysteine	NOUN
dti-1325	35	28	residues	residue	NOUN
dti-1325	35	29	with	with	ADP
dti-1325	35	30	alanine	alanine	NOUN
dti-1325	35	31	(	(	PUNCT
dti-1325	35	32	c499a	c499a	NOUN
dti-1325	35	33	and	and	CCONJ
dti-1325	35	34	c512a	c512a	PROPN
dti-1325	35	35	)	)	PUNCT
dti-1325	35	36	of	of	ADP
dti-1325	35	37	the	the	DET
dti-1325	35	38	p4	p4	ADJ
dti-1325	35	39	peptide	peptide	NOUN
dti-1325	35	40	region	region	NOUN
dti-1325	35	41	and	and	CCONJ
dti-1325	35	42	expressing	express	VERB
dti-1325	35	43	them	they	PRON
dti-1325	35	44	with	with	ADP
dti-1325	35	45	wild	wild	ADJ
dti-1325	35	46	type	type	NOUN
dti-1325	35	47	αiib	αiib	NOUN
dti-1325	35	48	,	,	PUNCT
dti-1325	35	49	as	as	ADV
dti-1325	35	50	well	well	ADV
dti-1325	35	51	as	as	ADP
dti-1325	35	52	expressing	express	VERB
dti-1325	35	53	αiib	αiib	ADJ
dti-1325	35	54	/	/	SYM
dti-1325	35	55	β3	β3	ADJ
dti-1325	35	56	-	-	PUNCT
dti-1325	35	57	wild	wild	ADJ
dti-1325	35	58	type	type	NOUN
dti-1325	35	59	in	in	ADP
dti-1325	35	60	chinese	chinese	ADJ
dti-1325	35	61	hamster	hamster	NOUN
dti-1325	35	62	ovary	ovary	ADJ
dti-1325	35	63	cells	cell	NOUN
dti-1325	35	64	(	(	PUNCT
dti-1325	35	65	cho	cho	NOUN
dti-1325	35	66	)	)	PUNCT
dti-1325	35	67	.	.	PUNCT
dti-1325	36	1	we	we	PRON
dti-1325	36	2	examined	examine	VERB
dti-1325	36	3	the	the	DET
dti-1325	36	4	binding	bind	VERB
dti-1325	36	5	ability	ability	NOUN
dti-1325	36	6	of	of	ADP
dti-1325	36	7	the	the	DET
dti-1325	36	8	mutant	mutant	NOUN
dti-1325	36	9	compared	compare	VERB
dti-1325	36	10	with	with	ADP
dti-1325	36	11	wild	wild	ADJ
dti-1325	36	12	type	type	NOUN
dti-1325	36	13	to	to	ADP
dti-1325	36	14	fitc	fitc	NOUN
dti-1325	36	15	-	-	PUNCT
dti-1325	36	16	pac-1	pac-1	NOUN
dti-1325	36	17	and	and	CCONJ
dti-1325	36	18	[	[	X
dti-1325	36	19	3h]-fi	3h]-fi	NUM
dti-1325	36	20	brinogen	brinogen	NOUN
dti-1325	36	21	.	.	PUNCT
dti-1325	37	1	results	result	NOUN
dti-1325	37	2	show	show	VERB
dti-1325	37	3	that	that	SCONJ
dti-1325	37	4	co	co	NOUN
dti-1325	37	5	-	-	NOUN
dti-1325	37	6	transfection	transfection	NOUN
dti-1325	37	7	with	with	ADP
dti-1325	37	8	the	the	DET
dti-1325	37	9	mutated	mutate	VERB
dti-1325	37	10	cdnas	cdna	NOUN
dti-1325	37	11	expresses	express	VERB
dti-1325	37	12	an	an	DET
dti-1325	37	13	inactive	inactive	ADJ
dti-1325	37	14	complex	complex	NOUN
dti-1325	37	15	and	and	CCONJ
dti-1325	37	16	binds	bind	VERB
dti-1325	37	17	less	less	ADJ
dti-1325	37	18	fitc	fitc	NOUN
dti-1325	37	19	-	-	PUNCT
dti-1325	37	20	pac-1	pac-1	NOUN
dti-1325	37	21	as	as	ADP
dti-1325	37	22	compared	compare	VERB
dti-1325	37	23	to	to	ADP
dti-1325	37	24	wild	wild	ADJ
dti-1325	37	25	type	type	NOUN
dti-1325	37	26	.	.	PUNCT
dti-1325	38	1	in	in	ADP
dti-1325	38	2	addition	addition	NOUN
dti-1325	38	3	,	,	PUNCT
dti-1325	38	4	a	a	DET
dti-1325	38	5	chemically	chemically	ADV
dti-1325	38	6	synthesized	synthesize	VERB
dti-1325	38	7	peptide	peptide	NOUN
dti-1325	38	8	(	(	PUNCT
dti-1325	38	9	of	of	ADP
dti-1325	38	10	the	the	DET
dti-1325	38	11	defi	defi	PROPN
dti-1325	38	12	ned	ned	PROPN
dti-1325	38	13	region	region	PROPN
dti-1325	38	14	)	)	PUNCT
dti-1325	38	15	inhibited	inhibit	VERB
dti-1325	38	16	the	the	DET
dti-1325	38	17	binding	binding	NOUN
dti-1325	38	18	of	of	ADP
dti-1325	38	19	fitc	fitc	NOUN
dti-1325	38	20	-	-	PUNCT
dti-1325	38	21	pac-1	pac-1	NOUN
dti-1325	38	22	as	as	ADV
dti-1325	38	23	well	well	ADV
dti-1325	38	24	as	as	ADP
dti-1325	38	25	inhibiting	inhibit	VERB
dti-1325	38	26	the	the	DET
dti-1325	38	27	binding	binding	NOUN
dti-1325	38	28	of	of	ADP
dti-1325	38	29	[	[	X
dti-1325	38	30	3h]-fibrinogen	3h]-fibrinogen	NUM
dti-1325	38	31	onto	onto	ADP
dti-1325	38	32	mn2	mn2	ADJ
dti-1325	38	33	+	+	CCONJ
dti-1325	38	34	-activated	-activated	ADJ
dti-1325	38	35	wild	wild	ADJ
dti-1325	38	36	type	type	NOUN
dti-1325	38	37	αiib	αiib	NOUN
dti-1325	38	38	/	/	SYM
dti-1325	38	39	β3	β3	PROPN
dti-1325	38	40	expressed	express	VERB
dti-1325	38	41	in	in	ADP
dti-1325	38	42	cho	cho	NOUN
dti-1325	38	43	cells	cell	NOUN
dti-1325	38	44	.	.	PUNCT
dti-1325	39	1	these	these	DET
dti-1325	39	2	results	result	NOUN
dti-1325	39	3	suggest	suggest	VERB
dti-1325	39	4	that	that	SCONJ
dti-1325	39	5	the	the	DET
dti-1325	39	6	p4	p4	ADJ
dti-1325	39	7	peptide	peptide	NOUN
dti-1325	39	8	of	of	ADP
dti-1325	39	9	β3	β3	ADJ
dti-1325	39	10	and	and	CCONJ
dti-1325	39	11	its	its	PRON
dti-1325	39	12	cysteine	cysteine	NOUN
dti-1325	39	13	residues	residue	NOUN
dti-1325	39	14	play	play	VERB
dti-1325	39	15	an	an	DET
dti-1325	39	16	important	important	ADJ
dti-1325	39	17	role	role	NOUN
dti-1325	39	18	in	in	ADP
dti-1325	39	19	the	the	DET
dti-1325	39	20	formation	formation	NOUN
dti-1325	39	21	of	of	ADP
dti-1325	39	22	the	the	DET
dti-1325	39	23	active	active	ADJ
dti-1325	39	24	complex	complex	NOUN
dti-1325	39	25	of	of	ADP
dti-1325	39	26	αiib	αiib	NOUN
dti-1325	39	27	/	/	SYM
dti-1325	39	28	β3	β3	ADJ
dti-1325	39	29	.	.	PUNCT
dti-1325	39	30	material	material	NOUN
dti-1325	39	31	and	and	CCONJ
dti-1325	39	32	methods	method	NOUN
dti-1325	39	33	reagents	reagent	NOUN
dti-1325	39	34	monoclonal	monoclonal	ADJ
dti-1325	39	35	anti	anti	ADJ
dti-1325	39	36	-	-	ADJ
dti-1325	39	37	β3	β3	ADJ
dti-1325	39	38	was	be	AUX
dti-1325	39	39	purchased	purchase	VERB
dti-1325	39	40	from	from	ADP
dti-1325	39	41	r&d	r&d	NOUN
dti-1325	39	42	systems	system	NOUN
dti-1325	39	43	,	,	PUNCT
dti-1325	39	44	inc	inc	PROPN
dti-1325	39	45	.	.	PROPN
dti-1325	39	46	(	(	PUNCT
dti-1325	39	47	minneapolis	minneapolis	PROPN
dti-1325	39	48	,	,	PUNCT
dti-1325	39	49	mn	mn	PROPN
dti-1325	39	50	)	)	PUNCT
dti-1325	39	51	and	and	CCONJ
dti-1325	39	52	monoclonal	monoclonal	ADJ
dti-1325	39	53	anti	anti	ADJ
dti-1325	39	54	-	-	ADJ
dti-1325	39	55	αiib	αiib	ADJ
dti-1325	39	56	(	(	PUNCT
dti-1325	39	57	clone	clone	NOUN
dti-1325	39	58	sz22	sz22	PROPN
dti-1325	39	59	)	)	PUNCT
dti-1325	39	60	was	be	AUX
dti-1325	39	61	purchased	purchase	VERB
dti-1325	39	62	from	from	ADP
dti-1325	39	63	beckman	beckman	PROPN
dti-1325	39	64	coulter	coulter	PROPN
dti-1325	39	65	(	(	PUNCT
dti-1325	39	66	fullerton	fullerton	PROPN
dti-1325	39	67	,	,	PUNCT
dti-1325	39	68	ca	ca	NOUN
dti-1325	39	69	)	)	PUNCT
dti-1325	39	70	.	.	PUNCT
dti-1325	40	1	the	the	DET
dti-1325	40	2	monoclonal	monoclonal	NOUN
dti-1325	40	3	antibody	antibody	NOUN
dti-1325	40	4	,	,	PUNCT
dti-1325	40	5	which	which	PRON
dti-1325	40	6	recognizes	recognize	VERB
dti-1325	40	7	the	the	DET
dti-1325	40	8	inactive	inactive	ADJ
dti-1325	40	9	complex	complex	NOUN
dti-1325	40	10	of	of	ADP
dti-1325	40	11	αiib	αiib	NOUN
dti-1325	40	12	/	/	SYM
dti-1325	40	13	β3	β3	PROPN
dti-1325	40	14	,	,	PUNCT
dti-1325	40	15	ap2	ap2	PROPN
dti-1325	40	16	,	,	PUNCT
dti-1325	40	17	was	be	AUX
dti-1325	40	18	purchased	purchase	VERB
dti-1325	40	19	from	from	ADP
dti-1325	40	20	gti	gti	NOUN
dti-1325	40	21	diagnostics	diagnostic	NOUN
dti-1325	40	22	(	(	PUNCT
dti-1325	40	23	waukesha	waukesha	PROPN
dti-1325	40	24	,	,	PUNCT
dti-1325	40	25	wi	wi	PROPN
dti-1325	40	26	)	)	PUNCT
dti-1325	40	27	.	.	PUNCT
dti-1325	41	1	the	the	DET
dti-1325	41	2	chinese	chinese	ADJ
dti-1325	41	3	hamster	hamster	PROPN
dti-1325	41	4	ovary	ovary	NOUN
dti-1325	41	5	(	(	PUNCT
dti-1325	41	6	chok1	chok1	NOUN
dti-1325	41	7	)	)	PUNCT
dti-1325	41	8	cell	cell	NOUN
dti-1325	41	9	line	line	NOUN
dti-1325	41	10	was	be	AUX
dti-1325	41	11	purchased	purchase	VERB
dti-1325	41	12	from	from	ADP
dti-1325	41	13	america	america	PROPN
dti-1325	41	14	type	type	PROPN
dti-1325	41	15	culture	culture	NOUN
dti-1325	41	16	collection	collection	NOUN
dti-1325	41	17	(	(	PUNCT
dti-1325	41	18	atcc	atcc	NOUN
dti-1325	41	19	)	)	PUNCT
dti-1325	41	20	(	(	PUNCT
dti-1325	41	21	manassas	manassas	PROPN
dti-1325	41	22	,	,	PUNCT
dti-1325	41	23	va	va	NOUN
dti-1325	41	24	)	)	PUNCT
dti-1325	41	25	.	.	PUNCT
dti-1325	42	1	the	the	DET
dti-1325	42	2	transfection	transfection	NOUN
dti-1325	42	3	reagent	reagent	NOUN
dti-1325	42	4	,	,	PUNCT
dti-1325	42	5	lipofectamine	lipofectamine	NOUN
dti-1325	42	6	2000	2000	NUM
dti-1325	42	7	and	and	CCONJ
dti-1325	42	8	fluorescent	fluorescent	ADJ
dti-1325	42	9	dye	dye	NOUN
dti-1325	42	10	alexa	alexa	NOUN
dti-1325	42	11	fluor	fluor	NOUN
dti-1325	42	12	647	647	NUM
dti-1325	42	13	were	be	AUX
dti-1325	42	14	from	from	ADP
dti-1325	42	15	invitrogen	invitrogen	PROPN
dti-1325	42	16	(	(	PUNCT
dti-1325	42	17	carlsbad	carlsbad	PROPN
dti-1325	42	18	,	,	PUNCT
dti-1325	42	19	ca	ca	NOUN
dti-1325	42	20	)	)	PUNCT
dti-1325	42	21	.	.	PUNCT
dti-1325	43	1	all	all	DET
dti-1325	43	2	other	other	ADJ
dti-1325	43	3	chemicals	chemical	NOUN
dti-1325	43	4	were	be	AUX
dti-1325	43	5	from	from	ADP
dti-1325	43	6	sigma	sigma	PROPN
dti-1325	43	7	chemical	chemical	PROPN
dti-1325	43	8	co.	co.	PROPN
dti-1325	43	9	(	(	PUNCT
dti-1325	43	10	st	st	PROPN
dti-1325	43	11	.	.	PROPN
dti-1325	43	12	louis	louis	PROPN
dti-1325	43	13	,	,	PUNCT
dti-1325	43	14	mo	mo	PROPN
dti-1325	43	15	)	)	PUNCT
dti-1325	43	16	,	,	PUNCT
dti-1325	43	17	fisher	fisher	PROPN
dti-1325	43	18	scientifi	scientifi	PROPN
dti-1325	43	19	c	c	PROPN
dti-1325	43	20	(	(	PUNCT
dti-1325	43	21	st	st	PROPN
dti-1325	43	22	.	.	PROPN
dti-1325	43	23	louis	louis	PROPN
dti-1325	43	24	,	,	PUNCT
dti-1325	43	25	mo	mo	PROPN
dti-1325	43	26	)	)	PUNCT
dti-1325	43	27	,	,	PUNCT
dti-1325	43	28	bio	bio	PROPN
dti-1325	43	29	-	-	PROPN
dti-1325	43	30	rad	rad	PROPN
dti-1325	43	31	(	(	PUNCT
dti-1325	43	32	hercules	hercules	PROPN
dti-1325	43	33	,	,	PUNCT
dti-1325	43	34	ca	ca	NOUN
dti-1325	43	35	)	)	PUNCT
dti-1325	43	36	,	,	PUNCT
dti-1325	43	37	and	and	CCONJ
dti-1325	43	38	pierce	pierce	PROPN
dti-1325	43	39	(	(	PUNCT
dti-1325	43	40	rockford	rockford	PROPN
dti-1325	43	41	,	,	PUNCT
dti-1325	43	42	il	il	PROPN
dti-1325	43	43	)	)	PUNCT
dti-1325	43	44	.	.	PUNCT
dti-1325	44	1	gp	gp	PROPN
dti-1325	44	2	iib	iib	PROPN
dti-1325	44	3	cdna	cdna	PROPN
dti-1325	44	4	construct	construct	VERB
dti-1325	44	5	is	be	AUX
dti-1325	44	6	a	a	DET
dti-1325	44	7	gift	gift	NOUN
dti-1325	44	8	from	from	ADP
dti-1325	44	9	dr	dr	PROPN
dti-1325	44	10	.	.	PROPN
dti-1325	44	11	peter	peter	PROPN
dti-1325	44	12	newman	newman	PROPN
dti-1325	44	13	(	(	PUNCT
dti-1325	44	14	the	the	DET
dti-1325	44	15	blood	blood	NOUN
dti-1325	44	16	center	center	NOUN
dti-1325	44	17	of	of	ADP
dti-1325	44	18	southeastern	southeastern	PROPN
dti-1325	44	19	wisconsin	wisconsin	PROPN
dti-1325	44	20	,	,	PUNCT
dti-1325	44	21	inc	inc	PROPN
dti-1325	44	22	.	.	PROPN
dti-1325	44	23	milwaukee	milwaukee	PROPN
dti-1325	44	24	,	,	PUNCT
dti-1325	44	25	wi	wi	PROPN
dti-1325	44	26	)	)	PUNCT
dti-1325	44	27	.	.	PUNCT
dti-1325	45	1	preparation	preparation	NOUN
dti-1325	45	2	of	of	ADP
dti-1325	45	3	platelet	platelet	ADJ
dti-1325	45	4	-	-	PUNCT
dti-1325	45	5	rich	rich	ADJ
dti-1325	45	6	plasma	plasma	NOUN
dti-1325	45	7	(	(	PUNCT
dti-1325	45	8	prp	prp	NOUN
dti-1325	45	9	)	)	PUNCT
dti-1325	45	10	human	human	ADJ
dti-1325	45	11	blood	blood	NOUN
dti-1325	45	12	(	(	PUNCT
dti-1325	45	13	9	9	NUM
dti-1325	45	14	parts	part	NOUN
dti-1325	45	15	)	)	PUNCT
dti-1325	45	16	from	from	ADP
dti-1325	45	17	normal	normal	ADJ
dti-1325	45	18	volunteers	volunteer	NOUN
dti-1325	45	19	,	,	PUNCT
dti-1325	45	20	were	be	AUX
dti-1325	45	21	collected	collect	VERB
dti-1325	45	22	following	follow	VERB
dti-1325	45	23	an	an	DET
dti-1325	45	24	overnight	overnight	ADJ
dti-1325	45	25	fast	fast	ADV
dti-1325	45	26	,	,	PUNCT
dti-1325	45	27	in	in	ADP
dti-1325	45	28	polypropylene	polypropylene	NOUN
dti-1325	45	29	tubes	tube	NOUN
dti-1325	45	30	containing	contain	VERB
dti-1325	45	31	1	1	NUM
dti-1325	45	32	part	part	NOUN
dti-1325	45	33	3.8	3.8	NUM
dti-1325	45	34	%	%	NOUN
dti-1325	45	35	sodium	sodium	NOUN
dti-1325	45	36	citrate	citrate	NOUN
dti-1325	45	37	.	.	PUNCT
dti-1325	46	1	prp	prp	PROPN
dti-1325	46	2	was	be	AUX
dti-1325	46	3	prepared	prepare	VERB
dti-1325	46	4	by	by	ADP
dti-1325	46	5	centrifuging	centrifuge	VERB
dti-1325	46	6	the	the	DET
dti-1325	46	7	citrated	citrate	VERB
dti-1325	46	8	blood	blood	NOUN
dti-1325	46	9	at	at	ADP
dti-1325	46	10	room	room	NOUN
dti-1325	46	11	temperature	temperature	NOUN
dti-1325	46	12	for	for	ADP
dti-1325	46	13	10	10	NUM
dti-1325	46	14	minutes	minute	NOUN
dti-1325	46	15	at	at	ADP
dti-1325	46	16	226	226	NUM
dti-1325	46	17	×	×	NOUN
dti-1325	46	18	g	g	PROPN
dti-1325	46	19	(	(	PUNCT
dti-1325	46	20	chiang	chiang	PROPN
dti-1325	46	21	et	et	PROPN
dti-1325	46	22	al	al	PROPN
dti-1325	46	23	.	.	PROPN
dti-1325	46	24	1976	1976	NUM
dti-1325	46	25	)	)	PUNCT
dti-1325	46	26	.	.	PUNCT
dti-1325	47	1	whole	whole	ADJ
dti-1325	47	2	blood	blood	NOUN
dti-1325	47	3	and	and	CCONJ
dti-1325	47	4	prp	prp	PROPN
dti-1325	47	5	were	be	AUX
dti-1325	47	6	exposed	expose	VERB
dti-1325	47	7	to	to	ADP
dti-1325	47	8	plastic	plastic	ADJ
dti-1325	47	9	surfaces	surface	NOUN
dti-1325	47	10	or	or	CCONJ
dti-1325	47	11	siliconized	siliconize	VERB
dti-1325	47	12	vessels	vessel	NOUN
dti-1325	47	13	only	only	ADV
dti-1325	47	14	.	.	PUNCT
dti-1325	48	1	platelet	platelet	NOUN
dti-1325	48	2	counts	count	NOUN
dti-1325	48	3	of	of	ADP
dti-1325	48	4	the	the	DET
dti-1325	48	5	prp	prp	NOUN
dti-1325	48	6	ranged	range	VERB
dti-1325	48	7	from	from	ADP
dti-1325	48	8	200,000	200,000	NUM
dti-1325	48	9	to	to	PART
dti-1325	48	10	300,000	300,000	NUM
dti-1325	48	11	per	per	ADP
dti-1325	48	12	mm3	mm3	PROPN
dti-1325	48	13	.	.	PUNCT
dti-1325	49	1	the	the	DET
dti-1325	49	2	washed	washed	NOUN
dti-1325	49	3	platelets	platelet	VERB
dti-1325	49	4	for	for	ADP
dti-1325	49	5	binding	bind	VERB
dti-1325	49	6	assays	assay	NOUN
dti-1325	49	7	were	be	AUX
dti-1325	49	8	prepared	prepare	VERB
dti-1325	49	9	by	by	ADP
dti-1325	49	10	gently	gently	ADV
dti-1325	49	11	mixing	mix	VERB
dti-1325	49	12	equal	equal	ADJ
dti-1325	49	13	volumes	volume	NOUN
dti-1325	49	14	of	of	ADP
dti-1325	49	15	prp	prp	PROPN
dti-1325	49	16	and	and	CCONJ
dti-1325	49	17	20	20	NUM
dti-1325	49	18	mm	mm	NOUN
dti-1325	49	19	tris	tris	NOUN
dti-1325	49	20	-	-	PUNCT
dti-1325	49	21	hcl-130	hcl-130	NOUN
dti-1325	49	22	mm	mm	PROPN
dti-1325	49	23	nacl-1	nacl-1	NUM
dti-1325	49	24	mm	mm	PROPN
dti-1325	49	25	edta	edta	NOUN
dti-1325	49	26	,	,	PUNCT
dti-1325	49	27	ph	ph	X
dti-1325	49	28	7.4	7.4	NUM
dti-1325	49	29	(	(	PUNCT
dti-1325	49	30	tris	tris	NOUN
dti-1325	49	31	-	-	PUNCT
dti-1325	49	32	edta	edta	NOUN
dti-1325	49	33	)	)	PUNCT
dti-1325	49	34	,	,	PUNCT
dti-1325	49	35	centrifuged	centrifuge	VERB
dti-1325	49	36	at	at	ADP
dti-1325	49	37	1,000	1,000	NUM
dti-1325	49	38	×	×	NOUN
dti-1325	49	39	g	g	NOUN
dti-1325	49	40	for	for	ADP
dti-1325	49	41	5	5	NUM
dti-1325	49	42	min	min	NOUN
dti-1325	49	43	,	,	PUNCT
dti-1325	49	44	washed	wash	VERB
dti-1325	49	45	once	once	ADV
dti-1325	49	46	with	with	ADP
dti-1325	49	47	tris	tris	NOUN
dti-1325	49	48	-	-	PUNCT
dti-1325	49	49	edta	edta	NOUN
dti-1325	49	50	and	and	CCONJ
dti-1325	49	51	then	then	ADV
dti-1325	49	52	resuspended	resuspend	VERB
dti-1325	49	53	in	in	ADP
dti-1325	49	54	the	the	DET
dti-1325	49	55	tyrode	tyrode	NOUN
dti-1325	49	56	’s	’s	PART
dti-1325	49	57	buffer	buffer	NOUN
dti-1325	49	58	.	.	PUNCT
dti-1325	50	1	binding	bind	VERB
dti-1325	50	2	of	of	ADP
dti-1325	50	3	[	[	X
dti-1325	50	4	3h]-fi	3h]-fi	NUM
dti-1325	50	5	brinogen	brinogen	NOUN
dti-1325	50	6	to	to	PART
dti-1325	50	7	washed	wash	VERB
dti-1325	50	8	human	human	ADJ
dti-1325	50	9	platelets	platelet	NOUN
dti-1325	50	10	fibrinogen	fibrinogen	NOUN
dti-1325	50	11	was	be	AUX
dti-1325	50	12	labeled	label	VERB
dti-1325	50	13	with	with	ADP
dti-1325	50	14	[	[	NOUN
dti-1325	50	15	3h]-formaldehyde	3h]-formaldehyde	NUM
dti-1325	50	16	as	as	SCONJ
dti-1325	50	17	described	describe	VERB
dti-1325	50	18	by	by	ADP
dti-1325	50	19	others	other	NOUN
dti-1325	50	20	(	(	PUNCT
dti-1325	50	21	whitnack	whitnack	NOUN
dti-1325	50	22	et	et	PROPN
dti-1325	50	23	al	al	PROPN
dti-1325	50	24	.	.	PROPN
dti-1325	50	25	1985	1985	NUM
dti-1325	50	26	;	;	PUNCT
dti-1325	50	27	rice	rice	NOUN
dti-1325	50	28	et	et	PROPN
dti-1325	50	29	al	al	PROPN
dti-1325	50	30	.	.	PROPN
dti-1325	50	31	1971	1971	NUM
dti-1325	50	32	and	and	CCONJ
dti-1325	50	33	grinnell	grinnell	PROPN
dti-1325	50	34	,	,	PUNCT
dti-1325	50	35	1980	1980	NUM
dti-1325	50	36	)	)	PUNCT
dti-1325	50	37	.	.	PUNCT
dti-1325	51	1	briefl	briefl	PROPN
dti-1325	51	2	y	y	PROPN
dti-1325	51	3	,	,	PUNCT
dti-1325	51	4	human	human	ADJ
dti-1325	51	5	fibrinogen	fibrinogen	NOUN
dti-1325	51	6	was	be	AUX
dti-1325	51	7	dissolved	dissolve	VERB
dti-1325	51	8	in	in	ADP
dti-1325	51	9	pbs	pbs	PROPN
dti-1325	51	10	at	at	ADP
dti-1325	51	11	a	a	DET
dti-1325	51	12	concentration	concentration	NOUN
dti-1325	51	13	of	of	ADP
dti-1325	51	14	3.4	3.4	NUM
dti-1325	51	15	mg	mg	NOUN
dti-1325	51	16	of	of	ADP
dti-1325	51	17	clottable	clottable	ADJ
dti-1325	51	18	protein	protein	NOUN
dti-1325	51	19	per	per	ADP
dti-1325	51	20	ml	ml	X
dti-1325	51	21	(	(	PUNCT
dti-1325	51	22	10	10	NUM
dti-1325	51	23	µm	µm	NOUN
dti-1325	51	24	)	)	PUNCT
dti-1325	51	25	,	,	PUNCT
dti-1325	51	26	dialyzed	dialyze	VERB
dti-1325	51	27	against	against	ADP
dti-1325	51	28	pbs	pbs	PROPN
dti-1325	51	29	to	to	PART
dti-1325	51	30	remove	remove	VERB
dti-1325	51	31	salts	salt	NOUN
dti-1325	51	32	,	,	PUNCT
dti-1325	51	33	and	and	CCONJ
dti-1325	51	34	stored	store	VERB
dti-1325	51	35	at	at	ADP
dti-1325	51	36	–	–	PUNCT
dti-1325	51	37	20	20	NUM
dti-1325	51	38	°	°	NOUN
dti-1325	51	39	c	c	NOUN
dti-1325	51	40	.	.	PUNCT
dti-1325	52	1	fibrinogen	fibrinogen	PROPN
dti-1325	52	2	was	be	AUX
dti-1325	52	3	dissolved	dissolve	VERB
dti-1325	52	4	in	in	ADP
dti-1325	52	5	0.2	0.2	NUM
dti-1325	52	6	m	m	NOUN
dti-1325	52	7	sodium	sodium	NOUN
dti-1325	52	8	borate	borate	NOUN
dti-1325	52	9	(	(	PUNCT
dti-1325	52	10	ph	ph	NOUN
dti-1325	52	11	7.4	7.4	NUM
dti-1325	52	12	)	)	PUNCT
dti-1325	52	13	at	at	ADP
dti-1325	52	14	a	a	DET
dti-1325	52	15	concentration	concentration	NOUN
dti-1325	52	16	of	of	ADP
dti-1325	52	17	10	10	NUM
dti-1325	52	18	µm	µm	NUM
dti-1325	52	19	and	and	CCONJ
dti-1325	52	20	dialyzed	dialyze	VERB
dti-1325	52	21	against	against	ADP
dti-1325	52	22	the	the	DET
dti-1325	52	23	69	69	NUM
dti-1325	52	24	the	the	DET
dti-1325	52	25	beta3	beta3	X
dti-1325	52	26	499–513	499–513	NUM
dti-1325	52	27	peptide	peptide	NOUN
dti-1325	52	28	region	region	NOUN
dti-1325	52	29	is	be	AUX
dti-1325	52	30	required	require	VERB
dti-1325	52	31	for	for	ADP
dti-1325	52	32	alphaiib	alphaiib	ADJ
dti-1325	52	33	/	/	SYM
dti-1325	52	34	beta3	beta3	NOUN
dti-1325	52	35	active	active	ADJ
dti-1325	52	36	complex	complex	ADJ
dti-1325	52	37	drug	drug	NOUN
dti-1325	52	38	target	target	NOUN
dti-1325	52	39	insights	insight	NOUN
dti-1325	52	40	2008:3	2008:3	NUM
dti-1325	52	41	same	same	ADJ
dti-1325	52	42	buffer	buffer	NOUN
dti-1325	52	43	.	.	PUNCT
dti-1325	53	1	the	the	DET
dti-1325	53	2	fi	fi	NOUN
dti-1325	53	3	brinogen	brinogen	PROPN
dti-1325	53	4	was	be	AUX
dti-1325	53	5	then	then	ADV
dti-1325	53	6	subjected	subject	VERB
dti-1325	53	7	to	to	ADP
dti-1325	53	8	reductive	reductive	ADJ
dti-1325	53	9	n	n	CCONJ
dti-1325	53	10	-	-	PUNCT
dti-1325	53	11	methylation	methylation	NOUN
dti-1325	53	12	at	at	ADP
dti-1325	53	13	4	4	NUM
dti-1325	53	14	°	°	ADP
dti-1325	53	15	c	c	NOUN
dti-1325	53	16	with	with	ADP
dti-1325	53	17	0.1	0.1	NUM
dti-1325	53	18	volume	volume	NOUN
dti-1325	53	19	of	of	ADP
dti-1325	53	20	a	a	DET
dti-1325	53	21	1	1	NUM
dti-1325	53	22	%	%	NOUN
dti-1325	53	23	aqueous	aqueous	ADJ
dti-1325	53	24	solution	solution	NOUN
dti-1325	53	25	of	of	ADP
dti-1325	53	26	[	[	X
dti-1325	53	27	3h]-formaldehyde	3h]-formaldehyde	NUM
dti-1325	53	28	,	,	PUNCT
dti-1325	53	29	followed	follow	VERB
dti-1325	53	30	by	by	ADP
dti-1325	53	31	0.3	0.3	NUM
dti-1325	53	32	volume	volume	NOUN
dti-1325	53	33	of	of	ADP
dti-1325	53	34	sodium	sodium	NOUN
dti-1325	53	35	borohydride	borohydride	NOUN
dti-1325	53	36	.	.	PUNCT
dti-1325	54	1	the	the	DET
dti-1325	54	2	labeled	label	VERB
dti-1325	54	3	fibrinogen	fibrinogen	NOUN
dti-1325	54	4	was	be	AUX
dti-1325	54	5	dialyzed	dialyze	VERB
dti-1325	54	6	against	against	ADP
dti-1325	54	7	pbs	pbs	PROPN
dti-1325	54	8	,	,	PUNCT
dti-1325	54	9	assessed	assess	VERB
dti-1325	54	10	for	for	ADP
dti-1325	54	11	amount	amount	NOUN
dti-1325	54	12	of	of	ADP
dti-1325	54	13	bound	bind	VERB
dti-1325	54	14	radiolabel	radiolabel	NOUN
dti-1325	54	15	,	,	PUNCT
dti-1325	54	16	assayed	assayed	ADJ
dti-1325	54	17	for	for	ADP
dti-1325	54	18	binding	bind	VERB
dti-1325	54	19	capacity	capacity	NOUN
dti-1325	54	20	and	and	CCONJ
dti-1325	54	21	fi	fi	NOUN
dti-1325	54	22	nally	nally	ADV
dti-1325	54	23	,	,	PUNCT
dti-1325	54	24	stored	store	VERB
dti-1325	54	25	at	at	ADP
dti-1325	54	26	−20	−20	PROPN
dti-1325	54	27	°	°	PROPN
dti-1325	54	28	c	c	NOUN
dti-1325	54	29	.	.	PUNCT
dti-1325	55	1	the	the	DET
dti-1325	55	2	binding	bind	VERB
dti-1325	55	3	mixture	mixture	NOUN
dti-1325	55	4	consisted	consist	VERB
dti-1325	55	5	of	of	ADP
dti-1325	55	6	washed	wash	VERB
dti-1325	55	7	human	human	ADJ
dti-1325	55	8	platelets	platelet	NOUN
dti-1325	55	9	(	(	PUNCT
dti-1325	55	10	108	108	NUM
dti-1325	55	11	)	)	PUNCT
dti-1325	55	12	in	in	ADP
dti-1325	55	13	tyrode	tyrode	NOUN
dti-1325	55	14	’s	’s	PART
dti-1325	55	15	buffer	buffer	NOUN
dti-1325	55	16	(	(	PUNCT
dti-1325	55	17	5	5	NUM
dti-1325	55	18	mm	mm	PROPN
dti-1325	55	19	hepes	hepe	NOUN
dti-1325	55	20	,	,	PUNCT
dti-1325	55	21	2	2	NUM
dti-1325	55	22	mm	mm	NOUN
dti-1325	55	23	mgcl2	mgcl2	PROPN
dti-1325	55	24	,	,	PUNCT
dti-1325	55	25	0.3	0.3	NUM
dti-1325	55	26	mm	mm	PROPN
dti-1325	55	27	nah2po4	nah2po4	PROPN
dti-1325	55	28	,	,	PUNCT
dti-1325	55	29	3	3	NUM
dti-1325	55	30	mm	mm	NOUN
dti-1325	55	31	kcl	kcl	PROPN
dti-1325	55	32	,	,	PUNCT
dti-1325	55	33	12	12	NUM
dti-1325	55	34	mm	mm	NUM
dti-1325	55	35	nahco3	nahco3	NOUN
dti-1325	55	36	,	,	PUNCT
dti-1325	55	37	0.1	0.1	NUM
dti-1325	55	38	%	%	NOUN
dti-1325	55	39	glucose	glucose	NOUN
dti-1325	55	40	,	,	PUNCT
dti-1325	55	41	0.1	0.1	NUM
dti-1325	55	42	%	%	NOUN
dti-1325	55	43	bsa	bsa	NOUN
dti-1325	55	44	,	,	PUNCT
dti-1325	55	45	and	and	CCONJ
dti-1325	55	46	1	1	NUM
dti-1325	55	47	mm	mm	NOUN
dti-1325	55	48	cacl2	cacl2	NOUN
dti-1325	55	49	,	,	PUNCT
dti-1325	55	50	ph	ph	NOUN
dti-1325	55	51	7.0	7.0	NUM
dti-1325	55	52	)	)	PUNCT
dti-1325	55	53	.	.	PUNCT
dti-1325	56	1	various	various	ADJ
dti-1325	56	2	amounts	amount	NOUN
dti-1325	56	3	of	of	ADP
dti-1325	56	4	p4	p4	ADJ
dti-1325	56	5	and	and	CCONJ
dti-1325	56	6	scrambled	scramble	VERB
dti-1325	56	7	p4s	p4s	NOUN
dti-1325	56	8	peptides	peptide	NOUN
dti-1325	56	9	(	(	PUNCT
dti-1325	56	10	0–80	0–80	NOUN
dti-1325	56	11	µm	µm	NOUN
dti-1325	56	12	)	)	PUNCT
dti-1325	56	13	were	be	AUX
dti-1325	56	14	used	use	VERB
dti-1325	56	15	to	to	PART
dti-1325	56	16	determine	determine	VERB
dti-1325	56	17	the	the	DET
dti-1325	56	18	dose	dose	NOUN
dti-1325	56	19	response	response	NOUN
dti-1325	56	20	of	of	ADP
dti-1325	56	21	inhibition	inhibition	NOUN
dti-1325	56	22	of	of	ADP
dti-1325	56	23	binding	bind	VERB
dti-1325	56	24	by	by	ADP
dti-1325	56	25	fi	fi	NOUN
dti-1325	56	26	brinogen	brinogen	NOUN
dti-1325	56	27	for	for	ADP
dti-1325	56	28	30	30	NUM
dti-1325	56	29	minutes	minute	NOUN
dti-1325	56	30	at	at	ADP
dti-1325	56	31	room	room	NOUN
dti-1325	56	32	temperature	temperature	NOUN
dti-1325	56	33	.	.	PUNCT
dti-1325	57	1	initiation	initiation	NOUN
dti-1325	57	2	of	of	ADP
dti-1325	57	3	the	the	DET
dti-1325	57	4	assay	assay	NOUN
dti-1325	57	5	began	begin	VERB
dti-1325	57	6	with	with	ADP
dti-1325	57	7	the	the	DET
dti-1325	57	8	addition	addition	NOUN
dti-1325	57	9	of	of	ADP
dti-1325	57	10	adp	adp	PROPN
dti-1325	57	11	(	(	PUNCT
dti-1325	57	12	final	final	ADJ
dti-1325	57	13	concentration	concentration	NOUN
dti-1325	57	14	of	of	ADP
dti-1325	57	15	0.5	0.5	NUM
dti-1325	57	16	µm	µm	NOUN
dti-1325	57	17	)	)	PUNCT
dti-1325	57	18	,	,	PUNCT
dti-1325	57	19	incubated	incubate	VERB
dti-1325	57	20	at	at	ADP
dti-1325	57	21	room	room	NOUN
dti-1325	57	22	temperature	temperature	NOUN
dti-1325	57	23	for	for	ADP
dti-1325	57	24	5	5	NUM
dti-1325	57	25	minutes	minute	NOUN
dti-1325	57	26	,	,	PUNCT
dti-1325	57	27	followed	follow	VERB
dti-1325	57	28	by	by	ADP
dti-1325	57	29	adding	add	VERB
dti-1325	57	30	[	[	X
dti-1325	57	31	3h]-fi	3h]-fi	NUM
dti-1325	57	32	brinogen	brinogen	NOUN
dti-1325	57	33	with	with	ADP
dti-1325	57	34	further	further	ADJ
dti-1325	57	35	incubation	incubation	NOUN
dti-1325	57	36	at	at	ADP
dti-1325	57	37	room	room	NOUN
dti-1325	57	38	temperature	temperature	NOUN
dti-1325	57	39	for	for	ADP
dti-1325	57	40	an	an	DET
dti-1325	57	41	hour	hour	NOUN
dti-1325	57	42	.	.	PUNCT
dti-1325	58	1	then	then	ADV
dti-1325	58	2	unbound	unbound	NOUN
dti-1325	59	1	[	[	X
dti-1325	59	2	3h]-fi	3h]-fi	NUM
dti-1325	59	3	brinogen	brinogen	NOUN
dti-1325	59	4	was	be	AUX
dti-1325	59	5	removed	remove	VERB
dti-1325	59	6	by	by	ADP
dti-1325	59	7	washing	wash	VERB
dti-1325	59	8	with	with	ADP
dti-1325	59	9	tyrode	tyrode	NOUN
dti-1325	59	10	’s	’s	PART
dti-1325	59	11	buffer	buffer	NOUN
dti-1325	59	12	three	three	NUM
dti-1325	59	13	times	time	NOUN
dti-1325	59	14	,	,	PUNCT
dti-1325	59	15	the	the	DET
dti-1325	59	16	pellet	pellet	NOUN
dti-1325	59	17	was	be	AUX
dti-1325	59	18	then	then	ADV
dti-1325	59	19	suspended	suspend	VERB
dti-1325	59	20	in	in	ADP
dti-1325	59	21	the	the	DET
dti-1325	59	22	same	same	ADJ
dti-1325	59	23	buffer	buffer	NOUN
dti-1325	59	24	and	and	CCONJ
dti-1325	59	25	transferred	transfer	VERB
dti-1325	59	26	to	to	ADP
dti-1325	59	27	scintillation	scintillation	NOUN
dti-1325	59	28	vials	vial	NOUN
dti-1325	59	29	containing	contain	VERB
dti-1325	59	30	7.5	7.5	NUM
dti-1325	59	31	ml	ml	NOUN
dti-1325	59	32	of	of	ADP
dti-1325	59	33	scintillation	scintillation	NOUN
dti-1325	59	34	solution	solution	NOUN
dti-1325	59	35	(	(	PUNCT
dti-1325	59	36	scintiverse	scintiverse	PROPN
dti-1325	59	37	bd	bd	PROPN
dti-1325	59	38	,	,	PUNCT
dti-1325	59	39	fisher	fisher	PROPN
dti-1325	59	40	scientifi	scientifi	PROPN
dti-1325	59	41	c	c	PROPN
dti-1325	59	42	,	,	PUNCT
dti-1325	59	43	pittsburgh	pittsburgh	PROPN
dti-1325	59	44	,	,	PUNCT
dti-1325	59	45	pa	pa	PROPN
dti-1325	59	46	)	)	PUNCT
dti-1325	59	47	.	.	PUNCT
dti-1325	60	1	radioactivity	radioactivity	NOUN
dti-1325	60	2	was	be	AUX
dti-1325	60	3	assessed	assess	VERB
dti-1325	60	4	with	with	ADP
dti-1325	60	5	a	a	DET
dti-1325	60	6	packard	packard	ADJ
dti-1325	60	7	liquid	liquid	ADJ
dti-1325	60	8	scintillation	scintillation	NOUN
dti-1325	60	9	analyzer	analyzer	NOUN
dti-1325	60	10	(	(	PUNCT
dti-1325	60	11	perkin	perkin	PROPN
dti-1325	60	12	elmer	elmer	PROPN
dti-1325	60	13	life	life	PROPN
dti-1325	60	14	and	and	CCONJ
dti-1325	60	15	analytical	analytical	ADJ
dti-1325	60	16	sci	sci	PROPN
dti-1325	60	17	.	.	PROPN
dti-1325	60	18	,	,	PUNCT
dti-1325	60	19	inc	inc	PROPN
dti-1325	60	20	.	.	PROPN
dti-1325	60	21	,	,	PUNCT
dti-1325	60	22	boston	boston	PROPN
dti-1325	60	23	,	,	PUNCT
dti-1325	60	24	ma	ma	PROPN
dti-1325	60	25	)	)	PUNCT
dti-1325	60	26	.	.	PUNCT
dti-1325	61	1	construction	construction	NOUN
dti-1325	61	2	and	and	CCONJ
dti-1325	61	3	expression	expression	NOUN
dti-1325	61	4	of	of	ADP
dti-1325	61	5	wild	wild	ADJ
dti-1325	61	6	type	type	NOUN
dti-1325	61	7	and	and	CCONJ
dti-1325	61	8	mutant	mutant	NOUN
dti-1325	61	9	β3	β3	ADJ
dti-1325	61	10	cdnas	cdna	NOUN
dti-1325	61	11	construction	construction	NOUN
dti-1325	61	12	of	of	ADP
dti-1325	61	13	a	a	DET
dti-1325	61	14	plasmid	plasmid	NOUN
dti-1325	61	15	encoding	encoding	NOUN
dti-1325	61	16	for	for	ADP
dti-1325	61	17	the	the	DET
dti-1325	61	18	fulllength	fulllength	NOUN
dti-1325	61	19	cdna	cdna	PROPN
dti-1325	61	20	of	of	ADP
dti-1325	61	21	platelet	platelet	NOUN
dti-1325	61	22	β3	β3	PROPN
dti-1325	61	23	were	be	AUX
dti-1325	61	24	from	from	ADP
dti-1325	61	25	several	several	ADJ
dti-1325	61	26	cdna	cdna	PROPN
dti-1325	61	27	fragments	fragment	NOUN
dti-1325	61	28	deposited	deposit	VERB
dti-1325	61	29	at	at	ADP
dti-1325	61	30	atcc	atcc	NOUN
dti-1325	61	31	and	and	CCONJ
dti-1325	61	32	subcloned	subclone	VERB
dti-1325	61	33	into	into	ADP
dti-1325	61	34	the	the	DET
dti-1325	61	35	vectors	vector	NOUN
dti-1325	61	36	pet-24a	pet-24a	NOUN
dti-1325	61	37	and	and	CCONJ
dti-1325	61	38	pcdna3.1	pcdna3.1	PROPN
dti-1325	61	39	.	.	PUNCT
dti-1325	62	1	the	the	DET
dti-1325	62	2	β3	β3	ADJ
dti-1325	62	3	-	-	PUNCT
dti-1325	62	4	mut	mut	PROPN
dti-1325	62	5	cdna	cdna	PROPN
dti-1325	62	6	is	be	AUX
dti-1325	62	7	a	a	DET
dti-1325	62	8	scrambling	scrambling	NOUN
dti-1325	62	9	of	of	ADP
dti-1325	62	10	the	the	DET
dti-1325	62	11	peptide	peptide	ADJ
dti-1325	62	12	sequence	sequence	NOUN
dti-1325	62	13	from	from	ADP
dti-1325	62	14	499–513	499–513	NUM
dti-1325	62	15	(	(	PUNCT
dti-1325	62	16	473–487	473–487	NUM
dti-1325	62	17	according	accord	VERB
dti-1325	62	18	to	to	ADP
dti-1325	62	19	numbering	number	VERB
dti-1325	62	20	by	by	ADP
dti-1325	62	21	kamata	kamata	PROPN
dti-1325	62	22	et	et	PROPN
dti-1325	62	23	al	al	PROPN
dti-1325	62	24	.	.	PROPN
dti-1325	62	25	2001	2001	NUM
dti-1325	62	26	)	)	PUNCT
dti-1325	62	27	of	of	ADP
dti-1325	62	28	β3	β3	ADJ
dti-1325	62	29	by	by	ADP
dti-1325	62	30	pcr	pcr	PROPN
dti-1325	62	31	.	.	PUNCT
dti-1325	63	1	the	the	DET
dti-1325	63	2	two	two	NUM
dti-1325	63	3	sets	set	NOUN
dti-1325	63	4	of	of	ADP
dti-1325	63	5	primers	primer	NOUN
dti-1325	63	6	used	use	VERB
dti-1325	63	7	were	be	AUX
dti-1325	63	8	,	,	PUNCT
dti-1325	63	9	forward	forward	ADV
dti-1325	63	10	primer	primer	NOUN
dti-1325	63	11	:	:	PUNCT
dti-1325	63	12	5’-acagatcttgcgagtattccgagcagtgcccccgggagggtcagcc-3	5’-acagatcttgcgagtattccgagcagtgcccccgggagggtcagcc-3	NUM
dti-1325	63	13	and	and	CCONJ
dti-1325	63	14	reverse	reverse	ADJ
dti-1325	63	15	primer	primer	NOUN
dti-1325	63	16	:	:	PUNCT
dti-1325	63	17	5’caagatctgtcgctaggctgctcgtcctcacactgggatcccagc-3	5’caagatctgtcgctaggctgctcgtcctcacactgggatcccagc-3	PROPN
dti-1325	63	18	’	'	PUNCT
dti-1325	63	19	.	.	PUNCT
dti-1325	64	1	the	the	DET
dti-1325	64	2	following	follow	VERB
dti-1325	64	3	primers	primer	NOUN
dti-1325	64	4	were	be	AUX
dti-1325	64	5	used	use	VERB
dti-1325	64	6	to	to	PART
dti-1325	64	7	construct	construct	VERB
dti-1325	64	8	the	the	DET
dti-1325	64	9	cdna	cdna	PROPN
dti-1325	64	10	with	with	ADP
dti-1325	64	11	c499a	c499a	NOUN
dti-1325	64	12	using	use	VERB
dti-1325	64	13	forward	forward	ADV
dti-1325	64	14	primer	primer	NOUN
dti-1325	64	15	:	:	PUNCT
dti-1325	64	16	5’-ggatcccagtgtgaggcctcagag-3	5’-ggatcccagtgtgaggcctcagag-3	NUM
dti-1325	64	17	’	'	PUNCT
dti-1325	64	18	and	and	CCONJ
dti-1325	64	19	reverse	reverse	ADJ
dti-1325	64	20	primer	primer	NOUN
dti-1325	64	21	:	:	PUNCT
dti-1325	64	22	5’-ctctgaggcctcacactgggatcc-3	5’-ctctgaggcctcacactgggatcc-3	NUM
dti-1325	64	23	’	'	PUNCT
dti-1325	64	24	and	and	CCONJ
dti-1325	64	25	the	the	DET
dti-1325	64	26	second	second	ADJ
dti-1325	64	27	cdna	cdna	PROPN
dti-1325	64	28	with	with	ADP
dti-1325	64	29	c512a	c512a	PROPN
dti-1325	64	30	using	use	VERB
dti-1325	64	31	forward	forward	ADV
dti-1325	64	32	primer	primer	NOUN
dti-1325	64	33	:	:	PUNCT
dti-1325	64	34	5’-gcaggacgaggccagcccccgg-3	5’-gcaggacgaggccagcccccgg-3	NUM
dti-1325	64	35	’	'	PUNCT
dti-1325	64	36	and	and	CCONJ
dti-1325	64	37	reverse	reverse	ADJ
dti-1325	64	38	primer	primer	NOUN
dti-1325	64	39	:	:	PUNCT
dti-1325	64	40	5’-cgggggctggcctcgtcctgc-3	5’-cgggggctggcctcgtcctgc-3	NUM
dti-1325	64	41	’	'	PUNCT
dti-1325	64	42	.	.	PUNCT
dti-1325	65	1	the	the	DET
dti-1325	65	2	template	template	NOUN
dti-1325	65	3	used	use	VERB
dti-1325	65	4	for	for	ADP
dti-1325	65	5	all	all	DET
dti-1325	65	6	pcr	pcr	ADJ
dti-1325	65	7	reactions	reaction	NOUN
dti-1325	65	8	was	be	AUX
dti-1325	65	9	β3	β3	ADJ
dti-1325	65	10	-	-	PUNCT
dti-1325	65	11	wild	wild	ADJ
dti-1325	65	12	type	type	NOUN
dti-1325	65	13	in	in	ADP
dti-1325	65	14	pcdna3.1	pcdna3.1	PROPN
dti-1325	65	15	.	.	PUNCT
dti-1325	66	1	all	all	PRON
dti-1325	66	2	of	of	ADP
dti-1325	66	3	the	the	DET
dti-1325	66	4	fi	fi	NOUN
dti-1325	66	5	nal	nal	ADJ
dti-1325	66	6	pcr	pcr	ADJ
dti-1325	66	7	products	product	NOUN
dti-1325	66	8	carrying	carry	VERB
dti-1325	66	9	the	the	DET
dti-1325	66	10	desired	desire	VERB
dti-1325	66	11	mutations	mutation	NOUN
dti-1325	66	12	in	in	ADP
dti-1325	66	13	the	the	DET
dti-1325	66	14	full	full	ADJ
dti-1325	66	15	-	-	PUNCT
dti-1325	66	16	length	length	NOUN
dti-1325	66	17	cdna	cdna	PROPN
dti-1325	66	18	were	be	AUX
dti-1325	66	19	treated	treat	VERB
dti-1325	66	20	with	with	ADP
dti-1325	66	21	dpn	dpn	PROPN
dti-1325	66	22	i	i	PROPN
dti-1325	66	23	,	,	PUNCT
dti-1325	66	24	purifi	purifi	PROPN
dti-1325	66	25	ed	ed	NOUN
dti-1325	66	26	,	,	PUNCT
dti-1325	66	27	transformed	transform	VERB
dti-1325	66	28	into	into	ADP
dti-1325	66	29	dh5α	dh5α	PROPN
dti-1325	66	30	,	,	PUNCT
dti-1325	66	31	selectively	selectively	ADV
dti-1325	66	32	screened	screen	VERB
dti-1325	66	33	,	,	PUNCT
dti-1325	66	34	and	and	CCONJ
dti-1325	66	35	sequence	sequence	NOUN
dti-1325	66	36	verified	verify	VERB
dti-1325	66	37	before	before	ADP
dti-1325	66	38	proceeding	proceed	VERB
dti-1325	66	39	with	with	ADP
dti-1325	66	40	expression	expression	NOUN
dti-1325	66	41	.	.	PUNCT
dti-1325	67	1	peptides	peptide	NOUN
dti-1325	67	2	for	for	ADP
dti-1325	67	3	inhibition	inhibition	NOUN
dti-1325	67	4	studies	study	NOUN
dti-1325	67	5	the	the	DET
dti-1325	67	6	first	first	ADJ
dti-1325	67	7	chemically	chemically	ADV
dti-1325	67	8	synthesized	synthesize	VERB
dti-1325	67	9	peptide	peptide	NOUN
dti-1325	67	10	is	be	AUX
dti-1325	67	11	c(acm)seedyrp	c(acm)seedyrp	PROPN
dti-1325	67	12	sqqdec(acm)s	sqqdec(acm)s	PROPN
dti-1325	67	13	,	,	PUNCT
dti-1325	67	14	which	which	PRON
dti-1325	67	15	we	we	PRON
dti-1325	67	16	referred	refer	VERB
dti-1325	67	17	to	to	ADP
dti-1325	67	18	as	as	ADP
dti-1325	67	19	p4	p4	ADJ
dti-1325	67	20	.	.	PUNCT
dti-1325	68	1	the	the	DET
dti-1325	68	2	second	second	ADJ
dti-1325	68	3	chemically	chemically	ADV
dti-1325	68	4	synthesized	synthesize	VERB
dti-1325	68	5	peptide	peptide	NOUN
dti-1325	68	6	is	be	AUX
dti-1325	68	7	the	the	DET
dti-1325	68	8	scrambled	scramble	VERB
dti-1325	68	9	version	version	NOUN
dti-1325	68	10	of	of	ADP
dti-1325	68	11	p4	p4	ADJ
dti-1325	68	12	,	,	PUNCT
dti-1325	68	13	sdc	sdc	NOUN
dti-1325	68	14	(	(	PUNCT
dti-1325	68	15	acm)eypeseqrsqdc(acm	acm)eypeseqrsqdc(acm	PROPN
dti-1325	68	16	)	)	PUNCT
dti-1325	68	17	,	,	PUNCT
dti-1325	68	18	which	which	PRON
dti-1325	68	19	served	serve	VERB
dti-1325	68	20	as	as	ADP
dti-1325	68	21	a	a	DET
dti-1325	68	22	control	control	NOUN
dti-1325	68	23	and	and	CCONJ
dti-1325	68	24	is	be	AUX
dti-1325	68	25	referred	refer	VERB
dti-1325	68	26	to	to	ADP
dti-1325	68	27	as	as	ADP
dti-1325	68	28	p4s	p4s	PROPN
dti-1325	68	29	.	.	PROPN
dti-1325	68	30	establishment	establishment	NOUN
dti-1325	68	31	of	of	ADP
dti-1325	68	32	stable	stable	ADJ
dti-1325	68	33	cell	cell	NOUN
dti-1325	68	34	lines	line	NOUN
dti-1325	68	35	for	for	ADP
dti-1325	68	36	eukaryotic	eukaryotic	ADJ
dti-1325	68	37	expression	expression	NOUN
dti-1325	68	38	in	in	ADP
dti-1325	68	39	cho	cho	NOUN
dti-1325	68	40	cells	cell	NOUN
dti-1325	68	41	and	and	CCONJ
dti-1325	68	42	immunoblot	immunoblot	NOUN
dti-1325	68	43	analyses	analyse	VERB
dti-1325	68	44	wild	wild	ADJ
dti-1325	68	45	type	type	NOUN
dti-1325	68	46	β3	β3	NOUN
dti-1325	68	47	or	or	CCONJ
dti-1325	68	48	mutant	mutant	ADJ
dti-1325	68	49	β3	β3	PROPN
dti-1325	68	50	(	(	PUNCT
dti-1325	68	51	β3	β3	ADJ
dti-1325	68	52	-	-	PUNCT
dti-1325	68	53	mut	mut	NOUN
dti-1325	68	54	)	)	PUNCT
dti-1325	68	55	(	(	PUNCT
dti-1325	68	56	4	4	NUM
dti-1325	68	57	µg	µg	VERB
dti-1325	68	58	of	of	ADP
dti-1325	68	59	each	each	DET
dti-1325	68	60	construct	construct	NOUN
dti-1325	68	61	)	)	PUNCT
dti-1325	68	62	and	and	CCONJ
dti-1325	68	63	wild	wild	ADJ
dti-1325	68	64	type	type	NOUN
dti-1325	68	65	αiib	αiib	NOUN
dti-1325	68	66	(	(	PUNCT
dti-1325	68	67	4	4	NUM
dti-1325	68	68	µg	µg	PRON
dti-1325	68	69	)	)	PUNCT
dti-1325	68	70	were	be	AUX
dti-1325	68	71	cotransfected	cotransfecte	VERB
dti-1325	68	72	into	into	ADP
dti-1325	68	73	cho	cho	NOUN
dti-1325	68	74	cell	cell	NOUN
dti-1325	68	75	using	use	VERB
dti-1325	68	76	lipofectamine	lipofectamine	NOUN
dti-1325	68	77	2000	2000	NUM
dti-1325	68	78	according	accord	VERB
dti-1325	68	79	to	to	ADP
dti-1325	68	80	the	the	DET
dti-1325	68	81	manufacturer	manufacturer	NOUN
dti-1325	68	82	’s	’s	PART
dti-1325	68	83	specifi	specifi	PROPN
dti-1325	68	84	cations	cation	NOUN
dti-1325	68	85	.	.	PUNCT
dti-1325	69	1	cells	cell	NOUN
dti-1325	69	2	were	be	AUX
dti-1325	69	3	incubated	incubate	VERB
dti-1325	69	4	37	37	NUM
dti-1325	69	5	°	°	ADP
dti-1325	69	6	c	c	NOUN
dti-1325	69	7	for	for	ADP
dti-1325	69	8	48	48	NUM
dti-1325	69	9	hours	hour	NOUN
dti-1325	69	10	following	follow	VERB
dti-1325	69	11	transfection	transfection	NOUN
dti-1325	69	12	,	,	PUNCT
dti-1325	69	13	allowing	allow	VERB
dti-1325	69	14	for	for	ADP
dti-1325	69	15	transgene	transgene	ADJ
dti-1325	69	16	expression	expression	NOUN
dti-1325	69	17	in	in	ADP
dti-1325	69	18	selective	selective	ADJ
dti-1325	69	19	media	medium	NOUN
dti-1325	69	20	containing	contain	VERB
dti-1325	69	21	700	700	NUM
dti-1325	69	22	µg	µg	NOUN
dti-1325	69	23	/	/	SYM
dti-1325	69	24	ml	ml	NOUN
dti-1325	69	25	of	of	ADP
dti-1325	69	26	geneticin	geneticin	PRON
dti-1325	69	27	for	for	ADP
dti-1325	69	28	two	two	NUM
dti-1325	69	29	weeks	week	NOUN
dti-1325	69	30	.	.	PUNCT
dti-1325	70	1	selected	select	VERB
dti-1325	70	2	single	single	ADJ
dti-1325	70	3	colonies	colony	NOUN
dti-1325	70	4	were	be	AUX
dti-1325	70	5	expanded	expand	VERB
dti-1325	70	6	to	to	ADP
dti-1325	70	7	24	24	NUM
dti-1325	70	8	-	-	PUNCT
dti-1325	70	9	well	well	NOUN
dti-1325	70	10	plates	plate	NOUN
dti-1325	70	11	and	and	CCONJ
dti-1325	70	12	the	the	DET
dti-1325	70	13	selected	select	VERB
dti-1325	70	14	integrant	integrant	NOUN
dti-1325	70	15	was	be	AUX
dti-1325	70	16	screened	screen	VERB
dti-1325	70	17	by	by	ADP
dti-1325	70	18	fl	fl	PRON
dti-1325	70	19	ow	ow	INTJ
dti-1325	70	20	cytometry	cytometry	PROPN
dti-1325	70	21	in	in	ADP
dti-1325	70	22	a	a	DET
dti-1325	70	23	bd	bd	PROPN
dti-1325	70	24	facs	facs	PROPN
dti-1325	70	25	calibur	calibur	PROPN
dti-1325	70	26	using	use	VERB
dti-1325	70	27	the	the	DET
dti-1325	70	28	ap2	ap2	NOUN
dti-1325	70	29	antibody	antibody	NOUN
dti-1325	70	30	conjugated	conjugate	VERB
dti-1325	70	31	to	to	ADP
dti-1325	70	32	the	the	DET
dti-1325	70	33	fl	fl	PROPN
dti-1325	70	34	uorescent	uorescent	ADJ
dti-1325	70	35	dye	dye	NOUN
dti-1325	70	36	(	(	PUNCT
dti-1325	70	37	alexa	alexa	NOUN
dti-1325	70	38	fluor	fluor	NOUN
dti-1325	70	39	647	647	NUM
dti-1325	70	40	)	)	PUNCT
dti-1325	70	41	.	.	PUNCT
dti-1325	71	1	following	follow	VERB
dti-1325	71	2	selection	selection	NOUN
dti-1325	71	3	,	,	PUNCT
dti-1325	71	4	the	the	DET
dti-1325	71	5	cells	cell	NOUN
dti-1325	71	6	are	be	AUX
dti-1325	71	7	maintained	maintain	VERB
dti-1325	71	8	in	in	ADP
dti-1325	71	9	selective	selective	ADJ
dti-1325	71	10	medium	medium	NOUN
dti-1325	71	11	with	with	ADP
dti-1325	71	12	700	700	NUM
dti-1325	71	13	µg	µg	NOUN
dti-1325	71	14	/	/	SYM
dti-1325	71	15	ml	ml	NOUN
dti-1325	71	16	of	of	ADP
dti-1325	71	17	geneticin	geneticin	PROPN
dti-1325	71	18	.	.	PUNCT
dti-1325	72	1	immunoblot	immunoblot	VERB
dti-1325	72	2	analysis	analysis	NOUN
dti-1325	72	3	with	with	ADP
dti-1325	72	4	both	both	PRON
dti-1325	72	5	,	,	PUNCT
dti-1325	72	6	αiib	αiib	ADJ
dti-1325	72	7	and	and	CCONJ
dti-1325	72	8	β3	β3	VERB
dti-1325	72	9	antibodies	antibody	NOUN
dti-1325	72	10	also	also	ADV
dti-1325	72	11	verifi	verifi	PROPN
dti-1325	72	12	ed	ed	PROPN
dti-1325	72	13	the	the	DET
dti-1325	72	14	successful	successful	ADJ
dti-1325	72	15	co	co	NOUN
dti-1325	72	16	-	-	NOUN
dti-1325	72	17	transfections	transfection	NOUN
dti-1325	72	18	.	.	PUNCT
dti-1325	73	1	flow	flow	VERB
dti-1325	73	2	cytometry	cytometry	ADJ
dti-1325	73	3	analysis	analysis	NOUN
dti-1325	73	4	of	of	ADP
dti-1325	73	5	activated	activate	VERB
dti-1325	73	6	of	of	ADP
dti-1325	73	7	αiib	αiib	ADJ
dti-1325	73	8	/	/	SYM
dti-1325	73	9	β3	β3	ADJ
dti-1325	73	10	complex	complex	ADJ
dti-1325	73	11	stable	stable	ADJ
dti-1325	73	12	cells	cell	NOUN
dti-1325	73	13	(	(	PUNCT
dti-1325	73	14	wild	wild	ADJ
dti-1325	73	15	type	type	NOUN
dti-1325	73	16	αiib	αiib	NOUN
dti-1325	73	17	/	/	SYM
dti-1325	73	18	β3	β3	ADJ
dti-1325	73	19	and	and	CCONJ
dti-1325	73	20	αiib	αiib	ADJ
dti-1325	73	21	/	/	SYM
dti-1325	73	22	β3	β3	ADJ
dti-1325	73	23	-	-	PUNCT
dti-1325	73	24	mut	mut	NOUN
dti-1325	73	25	)	)	PUNCT
dti-1325	73	26	were	be	AUX
dti-1325	73	27	harvested	harvest	VERB
dti-1325	73	28	with	with	ADP
dti-1325	73	29	0.5	0.5	NUM
dti-1325	73	30	mm	mm	NUM
dti-1325	73	31	edta	edta	PROPN
dti-1325	73	32	/	/	SYM
dti-1325	73	33	pbs	pbs	PROPN
dti-1325	73	34	ph	ph	PROPN
dti-1325	73	35	7.4	7.4	NUM
dti-1325	73	36	,	,	PUNCT
dti-1325	73	37	washed	wash	VERB
dti-1325	73	38	twice	twice	ADV
dti-1325	73	39	with	with	ADP
dti-1325	73	40	50	50	NUM
dti-1325	73	41	mm	mm	NUM
dti-1325	74	1	hepes/1	hepes/1	NUM
dti-1325	74	2	%	%	NOUN
dti-1325	74	3	glucose/2	glucose/2	PROPN
dti-1325	74	4	mm	mm	PROPN
dti-1325	74	5	ca2+/2	ca2+/2	PROPN
dti-1325	74	6	mm	mm	PROPN
dti-1325	74	7	mg2	mg2	PROPN
dti-1325	74	8	+	+	PROPN
dti-1325	74	9	ph	ph	ADJ
dti-1325	74	10	7.4	7.4	NUM
dti-1325	74	11	(	(	PUNCT
dti-1325	74	12	hepes	hepe	NOUN
dti-1325	74	13	buffer	buffer	VERB
dti-1325	74	14	i	i	PRON
dti-1325	74	15	)	)	PUNCT
dti-1325	75	1	and	and	CCONJ
dti-1325	75	2	resuspended	resuspend	VERB
dti-1325	75	3	in	in	ADP
dti-1325	75	4	50	50	NUM
dti-1325	75	5	mm	mm	NUM
dti-1325	76	1	hepes/1	hepes/1	NUM
dti-1325	77	1	%	%	NOUN
dti-1325	77	2	glucose/	glucose/	NOUN
dti-1325	77	3	1	1	NUM
dti-1325	77	4	mm	mm	PROPN
dti-1325	77	5	ca2+/1	ca2+/1	PROPN
dti-1325	77	6	mm	mm	PROPN
dti-1325	77	7	mg2	mg2	PROPN
dti-1325	77	8	+	+	PROPN
dti-1325	77	9	ph	ph	ADJ
dti-1325	77	10	7.4	7.4	NUM
dti-1325	77	11	.	.	PUNCT
dti-1325	78	1	(	(	PUNCT
dti-1325	78	2	hepes	hepe	NOUN
dti-1325	78	3	buffer	buffer	PROPN
dti-1325	78	4	ii	ii	PROPN
dti-1325	78	5	)	)	PUNCT
dti-1325	78	6	.	.	PUNCT
dti-1325	79	1	activation	activation	NOUN
dti-1325	79	2	of	of	ADP
dti-1325	79	3	the	the	DET
dti-1325	79	4	washed	wash	VERB
dti-1325	79	5	cells	cell	NOUN
dti-1325	79	6	(	(	PUNCT
dti-1325	79	7	1	1	NUM
dti-1325	79	8	×	×	NOUN
dti-1325	79	9	106	106	NUM
dti-1325	79	10	/	/	SYM
dti-1325	79	11	ml	ml	NOUN
dti-1325	79	12	)	)	PUNCT
dti-1325	79	13	were	be	AUX
dti-1325	79	14	initiated	initiate	VERB
dti-1325	79	15	by	by	ADP
dti-1325	79	16	the	the	DET
dti-1325	79	17	addition	addition	NOUN
dti-1325	79	18	of	of	ADP
dti-1325	79	19	2	2	NUM
dti-1325	79	20	mm	mm	NOUN
dti-1325	79	21	mn2	mn2	VERB
dti-1325	79	22	+	+	X
dti-1325	79	23	for	for	ADP
dti-1325	79	24	45	45	NUM
dti-1325	79	25	minutes	minute	NOUN
dti-1325	79	26	(	(	PUNCT
dti-1325	79	27	litvinov	litvinov	PROPN
dti-1325	79	28	et	et	PROPN
dti-1325	79	29	al	al	PROPN
dti-1325	79	30	.	.	PROPN
dti-1325	79	31	2004	2004	NUM
dti-1325	79	32	)	)	PUNCT
dti-1325	79	33	,	,	PUNCT
dti-1325	79	34	then	then	ADV
dti-1325	79	35	incubated	incubate	VERB
dti-1325	79	36	with	with	ADP
dti-1325	79	37	fitc	fitc	NOUN
dti-1325	79	38	-	-	PUNCT
dti-1325	79	39	pac-1	pac-1	NOUN
dti-1325	79	40	for	for	ADP
dti-1325	79	41	an	an	DET
dti-1325	79	42	additional	additional	ADJ
dti-1325	79	43	60	60	NUM
dti-1325	79	44	minutes	minute	NOUN
dti-1325	79	45	at	at	ADP
dti-1325	79	46	70	70	NUM
dti-1325	79	47	woo	woo	NOUN
dti-1325	79	48	-	-	PUNCT
dti-1325	79	49	rasberry	rasberry	NOUN
dti-1325	79	50	and	and	CCONJ
dti-1325	79	51	chiang	chiang	PROPN
dti-1325	79	52	drug	drug	PROPN
dti-1325	79	53	target	target	NOUN
dti-1325	79	54	insights	insight	NOUN
dti-1325	79	55	2008:3	2008:3	NUM
dti-1325	79	56	room	room	NOUN
dti-1325	79	57	temperature	temperature	NOUN
dti-1325	79	58	.	.	PUNCT
dti-1325	80	1	following	follow	VERB
dti-1325	80	2	three	three	NUM
dti-1325	80	3	washes	wash	NOUN
dti-1325	80	4	with	with	ADP
dti-1325	80	5	hepes	hepe	NOUN
dti-1325	80	6	buffer	buffer	PROPN
dti-1325	80	7	ii	ii	PROPN
dti-1325	80	8	,	,	PUNCT
dti-1325	80	9	the	the	DET
dti-1325	80	10	cells	cell	NOUN
dti-1325	80	11	were	be	AUX
dti-1325	80	12	resuspended	resuspend	VERB
dti-1325	80	13	in	in	ADP
dti-1325	80	14	the	the	DET
dti-1325	80	15	same	same	ADJ
dti-1325	80	16	buffer	buffer	NOUN
dti-1325	80	17	and	and	CCONJ
dti-1325	80	18	the	the	DET
dti-1325	80	19	amount	amount	NOUN
dti-1325	80	20	of	of	ADP
dti-1325	80	21	fitc	fitc	NOUN
dti-1325	80	22	-	-	PUNCT
dti-1325	80	23	pac-1	pac-1	NOUN
dti-1325	80	24	binding	bind	VERB
dti-1325	80	25	was	be	AUX
dti-1325	80	26	analyzed	analyze	VERB
dti-1325	80	27	by	by	ADP
dti-1325	80	28	fl	fl	INTJ
dti-1325	80	29	ow	ow	PROPN
dti-1325	80	30	cytometry	cytometry	PROPN
dti-1325	80	31	.	.	PUNCT
dti-1325	81	1	inhibition	inhibition	NOUN
dti-1325	81	2	of	of	ADP
dti-1325	81	3	αiib	αiib	ADJ
dti-1325	81	4	/	/	SYM
dti-1325	81	5	β3	β3	ADJ
dti-1325	81	6	active	active	ADJ
dti-1325	81	7	complex	complex	NOUN
dti-1325	81	8	by	by	ADP
dti-1325	81	9	peptides	peptide	NOUN
dti-1325	81	10	the	the	DET
dti-1325	81	11	chemically	chemically	ADV
dti-1325	81	12	synthesized	synthesize	VERB
dti-1325	81	13	peptides	peptide	NOUN
dti-1325	81	14	,	,	PUNCT
dti-1325	81	15	p4	p4	ADJ
dti-1325	81	16	and	and	CCONJ
dti-1325	81	17	p4s	p4s	PROPN
dti-1325	81	18	,	,	PUNCT
dti-1325	81	19	were	be	AUX
dti-1325	81	20	used	use	VERB
dti-1325	81	21	to	to	PART
dti-1325	81	22	determine	determine	VERB
dti-1325	81	23	whether	whether	SCONJ
dti-1325	81	24	they	they	PRON
dti-1325	81	25	could	could	AUX
dti-1325	81	26	inhibit	inhibit	VERB
dti-1325	81	27	the	the	DET
dti-1325	81	28	activation	activation	NOUN
dti-1325	81	29	of	of	ADP
dti-1325	81	30	the	the	DET
dti-1325	81	31	wild	wild	ADJ
dti-1325	81	32	type	type	NOUN
dti-1325	81	33	αiib	αiib	ADJ
dti-1325	81	34	/	/	SYM
dti-1325	81	35	β3	β3	NOUN
dti-1325	81	36	complex	complex	NOUN
dti-1325	81	37	.	.	PUNCT
dti-1325	82	1	again	again	ADV
dti-1325	82	2	,	,	PUNCT
dti-1325	82	3	cells	cell	NOUN
dti-1325	82	4	were	be	AUX
dti-1325	82	5	prepared	prepare	VERB
dti-1325	82	6	as	as	SCONJ
dti-1325	82	7	previously	previously	ADV
dti-1325	82	8	stated	state	VERB
dti-1325	82	9	,	,	PUNCT
dti-1325	82	10	incubated	incubate	VERB
dti-1325	82	11	with	with	ADP
dti-1325	82	12	varying	vary	VERB
dti-1325	82	13	amounts	amount	NOUN
dti-1325	82	14	of	of	ADP
dti-1325	82	15	peptide	peptide	NOUN
dti-1325	82	16	,	,	PUNCT
dti-1325	82	17	(	(	PUNCT
dti-1325	82	18	either	either	CCONJ
dti-1325	82	19	p4	p4	ADJ
dti-1325	82	20	or	or	CCONJ
dti-1325	82	21	p4s	p4s	PROPN
dti-1325	82	22	,	,	PUNCT
dti-1325	82	23	0–80	0–80	PROPN
dti-1325	82	24	µm	µm	NOUN
dti-1325	82	25	)	)	PUNCT
dti-1325	82	26	and	and	CCONJ
dti-1325	82	27	2	2	NUM
dti-1325	82	28	mm	mm	NOUN
dti-1325	82	29	mn2	mn2	VERB
dti-1325	82	30	+	+	X
dti-1325	82	31	for	for	ADP
dti-1325	82	32	45	45	NUM
dti-1325	82	33	minutes	minute	NOUN
dti-1325	82	34	,	,	PUNCT
dti-1325	82	35	followed	follow	VERB
dti-1325	82	36	by	by	ADP
dti-1325	82	37	incubation	incubation	NOUN
dti-1325	82	38	with	with	ADP
dti-1325	82	39	fitc	fitc	NOUN
dti-1325	82	40	-	-	PUNCT
dti-1325	82	41	pac-1	pac-1	NOUN
dti-1325	82	42	for	for	ADP
dti-1325	82	43	an	an	DET
dti-1325	82	44	additional	additional	ADJ
dti-1325	82	45	60	60	NUM
dti-1325	82	46	minutes	minute	NOUN
dti-1325	82	47	at	at	ADP
dti-1325	82	48	room	room	NOUN
dti-1325	82	49	temperature	temperature	NOUN
dti-1325	82	50	.	.	PUNCT
dti-1325	83	1	following	follow	VERB
dti-1325	83	2	immunostaining	immunostaine	VERB
dti-1325	83	3	,	,	PUNCT
dti-1325	83	4	all	all	DET
dti-1325	83	5	cells	cell	NOUN
dti-1325	83	6	were	be	AUX
dti-1325	83	7	washed	wash	VERB
dti-1325	83	8	three	three	NUM
dti-1325	83	9	times	time	NOUN
dti-1325	83	10	in	in	ADP
dti-1325	83	11	hepes	hepe	NOUN
dti-1325	83	12	buffer	buffer	PROPN
dti-1325	83	13	ii	ii	PROPN
dti-1325	83	14	,	,	PUNCT
dti-1325	83	15	resuspended	resuspend	VERB
dti-1325	83	16	in	in	ADP
dti-1325	83	17	the	the	DET
dti-1325	83	18	same	same	ADJ
dti-1325	83	19	buffer	buffer	NOUN
dti-1325	83	20	and	and	CCONJ
dti-1325	83	21	binding	binding	NOUN
dti-1325	83	22	was	be	AUX
dti-1325	83	23	analyzed	analyze	VERB
dti-1325	83	24	by	by	ADP
dti-1325	83	25	fl	fl	INTJ
dti-1325	83	26	ow	ow	PROPN
dti-1325	83	27	cytometry	cytometry	PROPN
dti-1325	83	28	.	.	PUNCT
dti-1325	84	1	binding	bind	VERB
dti-1325	84	2	of	of	ADP
dti-1325	84	3	[	[	X
dti-1325	84	4	3h]-fi	3h]-fi	NUM
dti-1325	84	5	brinogen	brinogen	NOUN
dti-1325	84	6	to	to	PART
dti-1325	84	7	stable	stable	VERB
dti-1325	84	8	co	co	VERB
dti-1325	84	9	-	-	ADJ
dti-1325	84	10	transfected	transfecte	VERB
dti-1325	84	11	cho	cho	NOUN
dti-1325	84	12	cells	cell	NOUN
dti-1325	84	13	binding	bind	VERB
dti-1325	84	14	mixture	mixture	NOUN
dti-1325	84	15	consisted	consist	VERB
dti-1325	84	16	of	of	ADP
dti-1325	84	17	co	co	ADJ
dti-1325	84	18	-	-	ADJ
dti-1325	84	19	transfected	transfecte	VERB
dti-1325	84	20	cho	cho	NOUN
dti-1325	84	21	cells	cell	NOUN
dti-1325	84	22	(	(	PUNCT
dti-1325	84	23	either	either	CCONJ
dti-1325	84	24	wild	wild	ADJ
dti-1325	84	25	type	type	NOUN
dti-1325	84	26	or	or	CCONJ
dti-1325	84	27	mutant	mutant	NOUN
dti-1325	84	28	,	,	PUNCT
dti-1325	84	29	5	5	NUM
dti-1325	84	30	×	×	NOUN
dti-1325	84	31	106	106	NUM
dti-1325	84	32	)	)	PUNCT
dti-1325	84	33	in	in	ADP
dti-1325	84	34	tyrode	tyrode	NOUN
dti-1325	84	35	’s	’s	PART
dti-1325	84	36	buffer	buffer	NOUN
dti-1325	84	37	.	.	PUNCT
dti-1325	85	1	the	the	DET
dti-1325	85	2	assay	assay	NOUN
dti-1325	85	3	was	be	AUX
dti-1325	85	4	initiated	initiate	VERB
dti-1325	85	5	by	by	ADP
dti-1325	85	6	adding	add	VERB
dti-1325	85	7	mn2	mn2	VERB
dti-1325	85	8	+	+	PROPN
dti-1325	85	9	to	to	ADP
dti-1325	85	10	fi	fi	NOUN
dti-1325	85	11	nal	nal	ADJ
dti-1325	85	12	a	a	DET
dti-1325	85	13	concentration	concentration	NOUN
dti-1325	85	14	of	of	ADP
dti-1325	85	15	2	2	NUM
dti-1325	85	16	mm	mm	NOUN
dti-1325	85	17	,	,	PUNCT
dti-1325	85	18	incubated	incubate	VERB
dti-1325	85	19	at	at	ADP
dti-1325	85	20	room	room	NOUN
dti-1325	85	21	temperature	temperature	NOUN
dti-1325	85	22	for	for	ADP
dti-1325	85	23	45	45	NUM
dti-1325	85	24	minutes	minute	NOUN
dti-1325	85	25	,	,	PUNCT
dti-1325	85	26	then	then	ADV
dti-1325	85	27	added	add	VERB
dti-1325	85	28	of	of	ADP
dti-1325	85	29	p4	p4	ADJ
dti-1325	85	30	or	or	CCONJ
dti-1325	85	31	p4s	p4s	PROPN
dti-1325	85	32	,	,	PUNCT
dti-1325	85	33	followed	follow	VERB
dti-1325	85	34	by	by	ADP
dti-1325	85	35	the	the	DET
dti-1325	85	36	addition	addition	NOUN
dti-1325	85	37	of	of	ADP
dti-1325	85	38	[	[	X
dti-1325	85	39	3h]fi	3h]fi	PROPN
dti-1325	85	40	brinogen	brinogen	NOUN
dti-1325	85	41	and	and	CCONJ
dti-1325	85	42	incubated	incubate	VERB
dti-1325	85	43	at	at	ADP
dti-1325	85	44	room	room	NOUN
dti-1325	85	45	temperature	temperature	NOUN
dti-1325	85	46	for	for	ADP
dti-1325	85	47	an	an	DET
dti-1325	85	48	additional	additional	ADJ
dti-1325	85	49	hour	hour	NOUN
dti-1325	85	50	.	.	PUNCT
dti-1325	86	1	following	follow	VERB
dti-1325	86	2	incubation	incubation	NOUN
dti-1325	86	3	,	,	PUNCT
dti-1325	86	4	the	the	DET
dti-1325	86	5	bound	bind	VERB
dti-1325	86	6	and	and	CCONJ
dti-1325	86	7	unbound	unbound	NOUN
dti-1325	86	8	[	[	X
dti-1325	86	9	3h]-fi	3h]-fi	NUM
dti-1325	86	10	brinogen	brinogen	NOUN
dti-1325	86	11	,	,	PUNCT
dti-1325	86	12	were	be	AUX
dti-1325	86	13	separated	separate	VERB
dti-1325	86	14	by	by	ADP
dti-1325	86	15	washing	wash	VERB
dti-1325	86	16	with	with	ADP
dti-1325	86	17	tyrode	tyrode	NOUN
dti-1325	86	18	’s	’s	PART
dti-1325	86	19	buffer	buffer	NOUN
dti-1325	86	20	three	three	NUM
dti-1325	86	21	times	time	NOUN
dti-1325	86	22	,	,	PUNCT
dti-1325	86	23	resuspended	resuspend	VERB
dti-1325	86	24	in	in	ADP
dti-1325	86	25	the	the	DET
dti-1325	86	26	same	same	ADJ
dti-1325	86	27	buffer	buffer	NOUN
dti-1325	86	28	and	and	CCONJ
dti-1325	86	29	transferred	transfer	VERB
dti-1325	86	30	to	to	ADP
dti-1325	86	31	scintillation	scintillation	NOUN
dti-1325	86	32	vials	vial	NOUN
dti-1325	86	33	containing	contain	VERB
dti-1325	86	34	7.5	7.5	NUM
dti-1325	86	35	ml	ml	NOUN
dti-1325	86	36	of	of	ADP
dti-1325	86	37	scintillation	scintillation	NOUN
dti-1325	86	38	solution	solution	NOUN
dti-1325	86	39	.	.	PUNCT
dti-1325	87	1	radioactivity	radioactivity	NOUN
dti-1325	87	2	was	be	AUX
dti-1325	87	3	determined	determine	VERB
dti-1325	87	4	with	with	ADP
dti-1325	87	5	a	a	DET
dti-1325	87	6	packard	packard	ADJ
dti-1325	87	7	tri	tri	ADJ
dti-1325	87	8	-	-	ADJ
dti-1325	87	9	carb	carb	ADJ
dti-1325	87	10	2000ca	2000ca	ADJ
dti-1325	87	11	liquid	liquid	ADJ
dti-1325	87	12	scintillation	scintillation	NOUN
dti-1325	87	13	analyzer	analyzer	NOUN
dti-1325	87	14	(	(	PUNCT
dti-1325	87	15	perkin	perkin	PROPN
dti-1325	87	16	elmer	elmer	PROPN
dti-1325	87	17	life	life	PROPN
dti-1325	87	18	and	and	CCONJ
dti-1325	87	19	analytical	analytical	ADJ
dti-1325	87	20	sci	sci	PROPN
dti-1325	87	21	.	.	PROPN
dti-1325	87	22	,	,	PUNCT
dti-1325	87	23	inc	inc	PROPN
dti-1325	87	24	.	.	PROPN
dti-1325	87	25	,	,	PUNCT
dti-1325	87	26	boston	boston	PROPN
dti-1325	87	27	,	,	PUNCT
dti-1325	87	28	ma	ma	PROPN
dti-1325	87	29	)	)	PUNCT
dti-1325	87	30	.	.	PUNCT
dti-1325	88	1	the	the	DET
dti-1325	88	2	effect	effect	NOUN
dti-1325	88	3	of	of	ADP
dti-1325	88	4	peptides	peptide	NOUN
dti-1325	88	5	,	,	PUNCT
dti-1325	88	6	p4	p4	ADJ
dti-1325	88	7	and	and	CCONJ
dti-1325	88	8	p4s	p4s	PROPN
dti-1325	88	9	,	,	PUNCT
dti-1325	88	10	on	on	ADP
dti-1325	88	11	[	[	X
dti-1325	88	12	3h]-fi	3h]-fi	NUM
dti-1325	88	13	brinogen	brinogen	NOUN
dti-1325	88	14	binding	binding	NOUN
dti-1325	88	15	followed	follow	VERB
dti-1325	88	16	the	the	DET
dti-1325	88	17	same	same	ADJ
dti-1325	88	18	binding	bind	VERB
dti-1325	88	19	assays	assay	NOUN
dti-1325	88	20	as	as	SCONJ
dti-1325	88	21	previously	previously	ADV
dti-1325	88	22	stated	state	VERB
dti-1325	88	23	,	,	PUNCT
dti-1325	88	24	with	with	ADP
dti-1325	88	25	the	the	DET
dti-1325	88	26	exception	exception	NOUN
dti-1325	88	27	that	that	SCONJ
dti-1325	88	28	varying	vary	VERB
dti-1325	88	29	amounts	amount	NOUN
dti-1325	88	30	of	of	ADP
dti-1325	88	31	each	each	DET
dti-1325	88	32	peptide	peptide	NOUN
dti-1325	88	33	are	be	AUX
dti-1325	88	34	incubated	incubate	VERB
dti-1325	88	35	with	with	ADP
dti-1325	88	36	the	the	DET
dti-1325	88	37	mn2	mn2	NOUN
dti-1325	88	38	+	+	NOUN
dti-1325	88	39	.	.	NOUN
dti-1325	88	40	results	result	NOUN
dti-1325	88	41	binding	bind	VERB
dti-1325	88	42	of	of	ADP
dti-1325	88	43	[	[	X
dti-1325	88	44	3h]-fi	3h]-fi	NUM
dti-1325	88	45	brinogen	brinogen	NOUN
dti-1325	88	46	on	on	SCONJ
dti-1325	88	47	washed	wash	VERB
dti-1325	88	48	human	human	ADJ
dti-1325	88	49	platelets	platelet	NOUN
dti-1325	88	50	we	we	PRON
dti-1325	88	51	have	have	AUX
dti-1325	88	52	established	establish	VERB
dti-1325	88	53	the	the	DET
dti-1325	88	54	optimum	optimum	ADJ
dti-1325	88	55	binding	bind	VERB
dti-1325	88	56	conditions	condition	NOUN
dti-1325	88	57	[	[	X
dti-1325	88	58	(	(	PUNCT
dti-1325	88	59	time	time	NOUN
dti-1325	88	60	(	(	PUNCT
dti-1325	88	61	one	one	NUM
dti-1325	88	62	hour	hour	NOUN
dti-1325	88	63	)	)	PUNCT
dti-1325	88	64	,	,	PUNCT
dti-1325	88	65	room	room	NOUN
dti-1325	88	66	temperature	temperature	NOUN
dti-1325	88	67	,	,	PUNCT
dti-1325	88	68	number	number	NOUN
dti-1325	88	69	of	of	ADP
dti-1325	88	70	platelets	platelet	NOUN
dti-1325	88	71	(	(	PUNCT
dti-1325	88	72	108	108	NUM
dti-1325	88	73	)	)	PUNCT
dti-1325	88	74	or	or	CCONJ
dti-1325	88	75	co	co	VERB
dti-1325	88	76	-	-	ADJ
dti-1325	88	77	transfected	transfecte	VERB
dti-1325	88	78	cho	cho	NOUN
dti-1325	88	79	cells	cell	NOUN
dti-1325	88	80	(	(	PUNCT
dti-1325	88	81	5	5	NUM
dti-1325	88	82	×	×	NOUN
dti-1325	88	83	106	106	NUM
dti-1325	88	84	)	)	PUNCT
dti-1325	88	85	,	,	PUNCT
dti-1325	88	86	and	and	CCONJ
dti-1325	88	87	concentration	concentration	NOUN
dti-1325	88	88	of	of	ADP
dti-1325	88	89	fi	fi	NOUN
dti-1325	88	90	brinogen	brinogen	NOUN
dti-1325	88	91	(	(	PUNCT
dti-1325	88	92	0.5	0.5	NUM
dti-1325	88	93	µm	µm	NOUN
dti-1325	88	94	)	)	PUNCT
dti-1325	88	95	]	]	PUNCT
dti-1325	88	96	for	for	ADP
dti-1325	88	97	the	the	DET
dti-1325	88	98	binding	bind	VERB
dti-1325	88	99	assay	assay	NOUN
dti-1325	88	100	(	(	PUNCT
dti-1325	88	101	data	datum	NOUN
dti-1325	88	102	not	not	PART
dti-1325	88	103	shown	show	VERB
dti-1325	88	104	)	)	PUNCT
dti-1325	88	105	.	.	PUNCT
dti-1325	89	1	using	use	VERB
dti-1325	89	2	the	the	DET
dti-1325	89	3	established	establish	VERB
dti-1325	89	4	conditions	condition	NOUN
dti-1325	89	5	,	,	PUNCT
dti-1325	89	6	we	we	PRON
dti-1325	89	7	tested	test	VERB
dti-1325	89	8	the	the	DET
dti-1325	89	9	effects	effect	NOUN
dti-1325	89	10	of	of	ADP
dti-1325	89	11	p4	p4	ADJ
dti-1325	89	12	and	and	CCONJ
dti-1325	89	13	p4s	p4s	NOUN
dti-1325	89	14	peptide	peptide	NOUN
dti-1325	89	15	on	on	ADP
dti-1325	89	16	the	the	DET
dti-1325	89	17	binding	binding	NOUN
dti-1325	89	18	of	of	ADP
dti-1325	89	19	[	[	X
dti-1325	89	20	3h]-fi	3h]-fi	NUM
dti-1325	89	21	brinogen	brinogen	NOUN
dti-1325	89	22	on	on	ADP
dti-1325	89	23	washed	wash	VERB
dti-1325	89	24	human	human	ADJ
dti-1325	89	25	platelets	platelet	NOUN
dti-1325	89	26	.	.	PUNCT
dti-1325	90	1	the	the	DET
dti-1325	90	2	amount	amount	NOUN
dti-1325	90	3	of	of	ADP
dti-1325	90	4	[	[	X
dti-1325	90	5	3h]fi	3h]fi	PROPN
dti-1325	90	6	brinogen	brinogen	NOUN
dti-1325	90	7	binding	bind	VERB
dti-1325	90	8	to	to	ADP
dti-1325	90	9	the	the	DET
dti-1325	90	10	platelets	platelet	NOUN
dti-1325	90	11	was	be	AUX
dti-1325	90	12	reduced	reduce	VERB
dti-1325	90	13	by	by	ADP
dti-1325	90	14	p4	p4	ADJ
dti-1325	90	15	(	(	PUNCT
dti-1325	90	16	fig	fig	NOUN
dti-1325	90	17	.	.	PUNCT
dti-1325	91	1	1	1	NUM
dti-1325	91	2	,	,	PUNCT
dti-1325	91	3	line	line	NOUN
dti-1325	91	4	with	with	ADP
dti-1325	91	5	diamonds	diamond	NOUN
dti-1325	91	6	)	)	PUNCT
dti-1325	91	7	.	.	PUNCT
dti-1325	92	1	the	the	DET
dti-1325	92	2	percent	percent	NOUN
dti-1325	92	3	inhibition	inhibition	NOUN
dti-1325	92	4	by	by	ADP
dti-1325	92	5	p4	p4	ADJ
dti-1325	92	6	is	be	AUX
dti-1325	92	7	dose	dose	NOUN
dti-1325	92	8	-	-	PUNCT
dti-1325	92	9	dependent	dependent	ADJ
dti-1325	92	10	.	.	PUNCT
dti-1325	93	1	treatment	treatment	NOUN
dti-1325	93	2	with	with	ADP
dti-1325	93	3	p4s	p4s	PROPN
dti-1325	93	4	did	do	AUX
dti-1325	93	5	not	not	PART
dti-1325	93	6	signifi	signifi	AUX
dti-1325	93	7	cantly	cantly	ADV
dti-1325	93	8	reduce	reduce	VERB
dti-1325	93	9	fi	fi	NOUN
dti-1325	93	10	brinogen	brinogen	NOUN
dti-1325	93	11	binding	bind	VERB
dti-1325	93	12	(	(	PUNCT
dti-1325	93	13	fig	fig	NOUN
dti-1325	93	14	.	.	PUNCT
dti-1325	94	1	1	1	NUM
dti-1325	94	2	,	,	PUNCT
dti-1325	94	3	line	line	NOUN
dti-1325	94	4	with	with	ADP
dti-1325	94	5	fi	fi	NOUN
dti-1325	94	6	lled	lle	VERB
dti-1325	94	7	squares	square	NOUN
dti-1325	94	8	)	)	PUNCT
dti-1325	94	9	.	.	PUNCT
dti-1325	95	1	in	in	ADP
dti-1325	95	2	addition	addition	NOUN
dti-1325	95	3	,	,	PUNCT
dti-1325	95	4	the	the	DET
dti-1325	95	5	p4	p4	ADJ
dti-1325	95	6	peptide	peptide	NOUN
dti-1325	95	7	could	could	AUX
dti-1325	95	8	not	not	PART
dti-1325	95	9	inhibit	inhibit	VERB
dti-1325	95	10	the	the	DET
dti-1325	95	11	binding	binding	NOUN
dti-1325	95	12	of	of	ADP
dti-1325	95	13	fi	fi	NOUN
dti-1325	95	14	brinogen	brinogen	NOUN
dti-1325	95	15	to	to	PART
dti-1325	95	16	platelets	platelet	NOUN
dti-1325	95	17	without	without	ADP
dti-1325	95	18	the	the	DET
dti-1325	95	19	addition	addition	NOUN
dti-1325	95	20	of	of	ADP
dti-1325	95	21	suboptimal	suboptimal	ADJ
dti-1325	95	22	concentrations	concentration	NOUN
dti-1325	95	23	of	of	ADP
dti-1325	95	24	adp	adp	PROPN
dti-1325	95	25	(	(	PUNCT
dti-1325	95	26	data	datum	NOUN
dti-1325	95	27	not	not	PART
dti-1325	95	28	shown	show	VERB
dti-1325	95	29	)	)	PUNCT
dti-1325	95	30	.	.	PUNCT
dti-1325	96	1	these	these	DET
dti-1325	96	2	results	result	NOUN
dti-1325	96	3	suggest	suggest	VERB
dti-1325	96	4	that	that	SCONJ
dti-1325	96	5	the	the	DET
dti-1325	96	6	peptide	peptide	NOUN
dti-1325	96	7	probably	probably	ADV
dti-1325	96	8	binds	bind	VERB
dti-1325	96	9	on	on	ADP
dti-1325	96	10	gp	gp	NOUN
dti-1325	96	11	iib	iib	PROPN
dti-1325	96	12	to	to	PART
dti-1325	96	13	inhibit	inhibit	VERB
dti-1325	96	14	the	the	DET
dti-1325	96	15	αiib	αiib	ADJ
dti-1325	96	16	/	/	SYM
dti-1325	96	17	β3	β3	ADJ
dti-1325	96	18	active	active	ADJ
dti-1325	96	19	complex	complex	ADJ
dti-1325	96	20	formation	formation	NOUN
dti-1325	96	21	rather	rather	ADV
dti-1325	96	22	than	than	ADP
dti-1325	96	23	directly	directly	ADV
dti-1325	96	24	affecting	affect	VERB
dti-1325	96	25	the	the	DET
dti-1325	96	26	fi	fi	NOUN
dti-1325	96	27	brinogen	brinogen	NOUN
dti-1325	96	28	binding	bind	VERB
dti-1325	96	29	to	to	ADP
dti-1325	96	30	the	the	DET
dti-1325	96	31	activated	activated	ADJ
dti-1325	96	32	complex	complex	NOUN
dti-1325	96	33	.	.	PUNCT
dti-1325	97	1	in	in	ADP
dti-1325	97	2	order	order	NOUN
dti-1325	97	3	to	to	PART
dti-1325	97	4	study	study	VERB
dti-1325	97	5	the	the	DET
dti-1325	97	6	effects	effect	NOUN
dti-1325	97	7	of	of	ADP
dti-1325	97	8	p4	p4	ADJ
dti-1325	97	9	(	(	PUNCT
dti-1325	97	10	wild	wild	ADJ
dti-1325	97	11	type	type	NOUN
dti-1325	97	12	β3	β3	PROPN
dti-1325	97	13	)	)	PUNCT
dti-1325	97	14	on	on	ADP
dti-1325	97	15	the	the	DET
dti-1325	97	16	formation	formation	NOUN
dti-1325	97	17	of	of	ADP
dti-1325	97	18	active	active	ADJ
dti-1325	97	19	αiib	αiib	NOUN
dti-1325	97	20	/	/	SYM
dti-1325	97	21	β3	β3	ADJ
dti-1325	97	22	,	,	PUNCT
dti-1325	97	23	we	we	PRON
dti-1325	97	24	have	have	AUX
dti-1325	97	25	engineered	engineer	VERB
dti-1325	97	26	a	a	DET
dti-1325	97	27	construct	construct	NOUN
dti-1325	97	28	containing	contain	VERB
dti-1325	97	29	the	the	DET
dti-1325	97	30	scrambled	scramble	VERB
dti-1325	97	31	sequence	sequence	NOUN
dti-1325	97	32	of	of	ADP
dti-1325	97	33	the	the	DET
dti-1325	97	34	active	active	ADJ
dti-1325	97	35	peptide	peptide	NOUN
dti-1325	97	36	(	(	PUNCT
dti-1325	97	37	p4s	p4s	PROPN
dti-1325	97	38	)	)	PUNCT
dti-1325	97	39	in	in	ADP
dti-1325	97	40	β3	β3	ADJ
dti-1325	97	41	cdna	cdna	PROPN
dti-1325	97	42	.	.	PUNCT
dti-1325	98	1	it	it	PRON
dti-1325	98	2	served	serve	VERB
dti-1325	98	3	as	as	ADP
dti-1325	98	4	a	a	DET
dti-1325	98	5	control	control	NOUN
dti-1325	98	6	(	(	PUNCT
dti-1325	98	7	named	name	VERB
dti-1325	98	8	as	as	ADP
dti-1325	98	9	β	β	NOUN
dti-1325	98	10	-	-	NOUN
dti-1325	98	11	mut	mut	NOUN
dti-1325	98	12	)	)	PUNCT
dti-1325	98	13	in	in	ADP
dti-1325	98	14	cotransfection	cotransfection	NOUN
dti-1325	98	15	with	with	ADP
dti-1325	98	16	wild	wild	ADJ
dti-1325	98	17	type	type	NOUN
dti-1325	98	18	αiib	αiib	PROPN
dti-1325	98	19	cdna	cdna	PROPN
dti-1325	98	20	into	into	ADP
dti-1325	98	21	cho	cho	NOUN
dti-1325	98	22	cells	cell	NOUN
dti-1325	98	23	and	and	CCONJ
dti-1325	98	24	proved	prove	VERB
dti-1325	98	25	that	that	SCONJ
dti-1325	98	26	the	the	DET
dti-1325	98	27	p4	p4	ADJ
dti-1325	98	28	peptide	peptide	NOUN
dti-1325	98	29	is	be	AUX
dti-1325	98	30	an	an	DET
dti-1325	98	31	inhibitor	inhibitor	NOUN
dti-1325	98	32	of	of	ADP
dti-1325	98	33	αiib	αiib	ADJ
dti-1325	98	34	/	/	SYM
dti-1325	98	35	β3	β3	ADJ
dti-1325	98	36	active	active	ADJ
dti-1325	98	37	complex	complex	ADJ
dti-1325	98	38	formation	formation	NOUN
dti-1325	98	39	.	.	PUNCT
dti-1325	99	1	recombinant	recombinant	ADJ
dti-1325	99	2	proteins	protein	NOUN
dti-1325	99	3	of	of	ADP
dti-1325	99	4	αiib	αiib	NOUN
dti-1325	99	5	,	,	PUNCT
dti-1325	99	6	β3	β3	ADJ
dti-1325	99	7	,	,	PUNCT
dti-1325	99	8	and	and	CCONJ
dti-1325	99	9	β3	β3	ADJ
dti-1325	99	10	-	-	PUNCT
dti-1325	99	11	mut	mut	NOUN
dti-1325	99	12	expressed	express	VERB
dti-1325	99	13	in	in	ADP
dti-1325	99	14	cho	cho	PROPN
dti-1325	99	15	cells	cell	NOUN
dti-1325	99	16	expressions	expression	NOUN
dti-1325	99	17	of	of	ADP
dti-1325	99	18	co	co	ADJ
dti-1325	99	19	-	-	ADJ
dti-1325	99	20	transfected	transfecte	VERB
dti-1325	99	21	proteins	protein	NOUN
dti-1325	99	22	,	,	PUNCT
dti-1325	99	23	αiib	αiib	NOUN
dti-1325	99	24	with	with	ADP
dti-1325	99	25	wild	wild	ADJ
dti-1325	99	26	type	type	NOUN
dti-1325	99	27	-	-	PUNCT
dti-1325	99	28	β3	β3	ADJ
dti-1325	99	29	or	or	CCONJ
dti-1325	99	30	β3	β3	ADJ
dti-1325	99	31	-	-	PUNCT
dti-1325	99	32	mut	mut	NOUN
dti-1325	99	33	were	be	AUX
dti-1325	99	34	examined	examine	VERB
dti-1325	99	35	by	by	ADP
dti-1325	99	36	immunoblot	immunoblot	NOUN
dti-1325	99	37	analyses	analysis	NOUN
dti-1325	99	38	.	.	PUNCT
dti-1325	100	1	figure	figure	NOUN
dti-1325	100	2	2	2	NUM
dti-1325	100	3	shows	show	VERB
dti-1325	100	4	that	that	SCONJ
dti-1325	100	5	both	both	DET
dti-1325	100	6	wild	wild	ADJ
dti-1325	100	7	type	type	NOUN
dti-1325	100	8	αiib	αiib	ADJ
dti-1325	100	9	and	and	CCONJ
dti-1325	100	10	wild	wild	ADJ
dti-1325	100	11	type	type	NOUN
dti-1325	100	12	β3	β3	ADJ
dti-1325	100	13	proteins	protein	NOUN
dti-1325	100	14	and	and	CCONJ
dti-1325	100	15	wild	wild	ADJ
dti-1325	100	16	type	type	NOUN
dti-1325	100	17	αiib	αiib	ADJ
dti-1325	100	18	and	and	CCONJ
dti-1325	100	19	β3	β3	ADJ
dti-1325	100	20	-	-	PUNCT
dti-1325	100	21	mut	mut	NOUN
dti-1325	100	22	were	be	AUX
dti-1325	100	23	detected	detect	VERB
dti-1325	100	24	in	in	ADP
dti-1325	100	25	co	co	VERB
dti-1325	100	26	-	-	ADJ
dti-1325	100	27	transfected	transfecte	VERB
dti-1325	100	28	cho	cho	NOUN
dti-1325	100	29	cell	cell	NOUN
dti-1325	100	30	lysates	lysate	NOUN
dti-1325	100	31	.	.	PUNCT
dti-1325	101	1	panels	panel	NOUN
dti-1325	101	2	a	a	PRON
dti-1325	101	3	and	and	CCONJ
dti-1325	101	4	b	b	NOUN
dti-1325	101	5	shows	show	VERB
dti-1325	101	6	a	a	DET
dti-1325	101	7	set	set	NOUN
dti-1325	101	8	of	of	ADP
dti-1325	101	9	immunoblots	immunoblot	NOUN
dti-1325	101	10	of	of	ADP
dti-1325	101	11	co	co	ADJ
dti-1325	101	12	-	-	ADJ
dti-1325	101	13	transfected	transfecte	VERB
dti-1325	101	14	cho	cho	NOUN
dti-1325	101	15	cells	cell	NOUN
dti-1325	101	16	(	(	PUNCT
dti-1325	101	17	lane	lane	NOUN
dti-1325	101	18	1	1	NUM
dti-1325	101	19	:	:	PUNCT
dti-1325	101	20	mock	mock	ADJ
dti-1325	101	21	,	,	PUNCT
dti-1325	101	22	lane	lane	NOUN
dti-1325	101	23	2	2	NUM
dti-1325	101	24	:	:	PUNCT
dti-1325	101	25	αiib	αiib	ADJ
dti-1325	101	26	/	/	SYM
dti-1325	101	27	β3	β3	ADJ
dti-1325	101	28	wild	wild	ADJ
dti-1325	101	29	type	type	NOUN
dti-1325	101	30	,	,	PUNCT
dti-1325	101	31	and	and	CCONJ
dti-1325	101	32	lane	lane	NOUN
dti-1325	101	33	3	3	NUM
dti-1325	101	34	:	:	PUNCT
dti-1325	101	35	αiib	αiib	ADJ
dti-1325	101	36	/	/	SYM
dti-1325	101	37	β3	β3	ADJ
dti-1325	101	38	-	-	PUNCT
dti-1325	101	39	mut	mut	NOUN
dti-1325	101	40	)	)	PUNCT
dti-1325	101	41	.	.	PUNCT
dti-1325	102	1	the	the	DET
dti-1325	102	2	αiib	αiib	ADJ
dti-1325	102	3	antibody	antibody	NOUN
dti-1325	102	4	recognized	recognize	VERB
dti-1325	102	5	αiib	αiib	PROPN
dti-1325	102	6	expressed	express	VERB
dti-1325	102	7	in	in	ADP
dti-1325	102	8	cho	cho	PROPN
dti-1325	102	9	cells	cell	NOUN
dti-1325	102	10	expressing	express	VERB
dti-1325	102	11	wild	wild	ADJ
dti-1325	102	12	type	type	NOUN
dti-1325	102	13	αiib	αiib	NOUN
dti-1325	102	14	/	/	SYM
dti-1325	102	15	β3	β3	ADJ
dti-1325	102	16	(	(	PUNCT
dti-1325	102	17	lane	lane	NOUN
dti-1325	102	18	2	2	NUM
dti-1325	102	19	)	)	PUNCT
dti-1325	102	20	and	and	CCONJ
dti-1325	102	21	αiib	αiib	ADJ
dti-1325	102	22	/	/	SYM
dti-1325	102	23	β3	β3	ADJ
dti-1325	102	24	-	-	PUNCT
dti-1325	102	25	mut	mut	NOUN
dti-1325	102	26	(	(	PUNCT
dti-1325	102	27	lane	lane	NOUN
dti-1325	102	28	3	3	NUM
dti-1325	102	29	)	)	PUNCT
dti-1325	102	30	as	as	SCONJ
dti-1325	102	31	shown	show	VERB
dti-1325	102	32	in	in	ADP
dti-1325	102	33	panel	panel	NOUN
dti-1325	102	34	a	a	DET
dti-1325	102	35	(	(	PUNCT
dti-1325	102	36	arrow	arrow	NOUN
dti-1325	102	37	)	)	PUNCT
dti-1325	102	38	.	.	PUNCT
dti-1325	103	1	in	in	ADP
dti-1325	103	2	addition	addition	NOUN
dti-1325	103	3	,	,	PUNCT
dti-1325	103	4	the	the	DET
dti-1325	103	5	β3	β3	ADJ
dti-1325	103	6	antibody	antibody	NOUN
dti-1325	103	7	recognized	recognize	VERB
dti-1325	103	8	β3	β3	ADJ
dti-1325	103	9	proteins	protein	NOUN
dti-1325	103	10	expressed	express	VERB
dti-1325	103	11	in	in	ADP
dti-1325	103	12	the	the	DET
dti-1325	103	13	wild	wild	ADJ
dti-1325	103	14	type	type	NOUN
dti-1325	103	15	αiib	αiib	NOUN
dti-1325	103	16	/	/	SYM
dti-1325	103	17	β3	β3	ADJ
dti-1325	103	18	(	(	PUNCT
dti-1325	103	19	lane	lane	NOUN
dti-1325	103	20	2	2	NUM
dti-1325	103	21	)	)	PUNCT
dti-1325	103	22	and	and	CCONJ
dti-1325	103	23	less	less	ADJ
dti-1325	103	24	in	in	ADP
dti-1325	103	25	αiib	αiib	ADJ
dti-1325	103	26	/	/	SYM
dti-1325	103	27	β3	β3	ADJ
dti-1325	103	28	-	-	PUNCT
dti-1325	103	29	mut	mut	NOUN
dti-1325	103	30	(	(	PUNCT
dti-1325	103	31	lane	lane	NOUN
dti-1325	103	32	3	3	NUM
dti-1325	103	33	)	)	PUNCT
dti-1325	103	34	as	as	SCONJ
dti-1325	103	35	shown	show	VERB
dti-1325	103	36	in	in	ADP
dti-1325	103	37	panel	panel	NOUN
dti-1325	103	38	b	b	PROPN
dti-1325	103	39	(	(	PUNCT
dti-1325	103	40	arrow	arrow	NOUN
dti-1325	103	41	)	)	PUNCT
dti-1325	103	42	.	.	PUNCT
dti-1325	104	1	we	we	PRON
dti-1325	104	2	have	have	AUX
dti-1325	104	3	then	then	ADV
dti-1325	104	4	used	use	VERB
dti-1325	104	5	fl	fl	PROPN
dti-1325	104	6	ow	ow	INTJ
dti-1325	104	7	cytometry	cytometry	NOUN
dti-1325	104	8	to	to	PART
dti-1325	104	9	study	study	VERB
dti-1325	104	10	the	the	DET
dti-1325	104	11	αiib	αiib	ADJ
dti-1325	104	12	/	/	SYM
dti-1325	104	13	β3	β3	ADJ
dti-1325	104	14	expression	expression	NOUN
dti-1325	104	15	in	in	ADP
dti-1325	104	16	co	co	VERB
dti-1325	104	17	-	-	ADJ
dti-1325	104	18	transfected	transfecte	VERB
dti-1325	104	19	cho	cho	NOUN
dti-1325	104	20	cells	cell	NOUN
dti-1325	104	21	.	.	PUNCT
dti-1325	105	1	figure	figure	NOUN
dti-1325	105	2	3	3	NUM
dti-1325	105	3	,	,	PUNCT
dti-1325	105	4	panel	panel	NOUN
dti-1325	105	5	a	a	PRON
dti-1325	105	6	showed	show	VERB
dti-1325	105	7	the	the	DET
dti-1325	105	8	presence	presence	NOUN
dti-1325	105	9	of	of	ADP
dti-1325	105	10	an	an	DET
dti-1325	105	11	inactive	inactive	ADJ
dti-1325	105	12	complex	complex	NOUN
dti-1325	105	13	,	,	PUNCT
dti-1325	105	14	identifi	identifi	PROPN
dti-1325	105	15	ed	ed	NOUN
dti-1325	105	16	by	by	ADP
dti-1325	105	17	the	the	DET
dti-1325	105	18	ap2	ap2	NOUN
dti-1325	105	19	antibody	antibody	NOUN
dti-1325	105	20	in	in	ADP
dti-1325	105	21	both	both	PRON
dti-1325	105	22	αiib	αiib	ADJ
dti-1325	105	23	/	/	SYM
dti-1325	105	24	β3	β3	ADJ
dti-1325	105	25	(	(	PUNCT
dti-1325	105	26	line	line	NOUN
dti-1325	105	27	2	2	NUM
dti-1325	105	28	)	)	PUNCT
dti-1325	105	29	and	and	CCONJ
dti-1325	105	30	αiib	αiib	ADJ
dti-1325	105	31	/	/	SYM
dti-1325	105	32	β3	β3	ADJ
dti-1325	105	33	-	-	PUNCT
dti-1325	105	34	mut	mut	NOUN
dti-1325	105	35	(	(	PUNCT
dti-1325	105	36	line	line	NOUN
dti-1325	105	37	3	3	NUM
dti-1325	105	38	)	)	PUNCT
dti-1325	105	39	.	.	PUNCT
dti-1325	106	1	the	the	DET
dti-1325	106	2	binding	bind	VERB
dti-1325	106	3	capacity	capacity	NOUN
dti-1325	106	4	of	of	ADP
dti-1325	106	5	ap2	ap2	PROPN
dti-1325	106	6	(	(	PUNCT
dti-1325	106	7	calculated	calculate	VERB
dti-1325	106	8	as	as	ADP
dti-1325	106	9	percentage	percentage	NOUN
dti-1325	106	10	gated	gate	VERB
dti-1325	106	11	subset	subset	NOUN
dti-1325	106	12	)	)	PUNCT
dti-1325	106	13	was	be	AUX
dti-1325	106	14	similar	similar	ADJ
dti-1325	106	15	between	between	ADP
dti-1325	106	16	71	71	NUM
dti-1325	106	17	the	the	DET
dti-1325	106	18	beta3	beta3	NOUN
dti-1325	106	19	499–513	499–513	NUM
dti-1325	106	20	peptide	peptide	NOUN
dti-1325	106	21	region	region	NOUN
dti-1325	106	22	is	be	AUX
dti-1325	106	23	required	require	VERB
dti-1325	106	24	for	for	ADP
dti-1325	106	25	alphaiib	alphaiib	ADJ
dti-1325	106	26	/	/	SYM
dti-1325	106	27	beta3	beta3	NOUN
dti-1325	106	28	active	active	ADJ
dti-1325	106	29	complex	complex	ADJ
dti-1325	106	30	drug	drug	NOUN
dti-1325	106	31	target	target	NOUN
dti-1325	106	32	insights	insight	NOUN
dti-1325	106	33	2008:3	2008:3	NUM
dti-1325	106	34	wild	wild	ADJ
dti-1325	106	35	type	type	NOUN
dti-1325	106	36	β3	β3	NOUN
dti-1325	106	37	and	and	CCONJ
dti-1325	106	38	β3	β3	ADJ
dti-1325	106	39	-	-	PUNCT
dti-1325	106	40	mut	mut	NOUN
dti-1325	106	41	.	.	PUNCT
dti-1325	107	1	the	the	DET
dti-1325	107	2	mutation	mutation	NOUN
dti-1325	107	3	made	make	VERB
dti-1325	107	4	in	in	ADP
dti-1325	107	5	β3	β3	ADJ
dti-1325	107	6	did	do	AUX
dti-1325	107	7	not	not	PART
dti-1325	107	8	interrupt	interrupt	VERB
dti-1325	107	9	the	the	DET
dti-1325	107	10	ability	ability	NOUN
dti-1325	107	11	for	for	SCONJ
dti-1325	107	12	the	the	DET
dti-1325	107	13	protein	protein	NOUN
dti-1325	107	14	to	to	PART
dti-1325	107	15	be	be	AUX
dti-1325	107	16	expressed	express	VERB
dti-1325	107	17	,	,	PUNCT
dti-1325	107	18	as	as	ADV
dti-1325	107	19	well	well	ADV
dti-1325	107	20	as	as	ADP
dti-1325	107	21	being	be	AUX
dti-1325	107	22	transported	transport	VERB
dti-1325	107	23	to	to	ADP
dti-1325	107	24	the	the	DET
dti-1325	107	25	cell	cell	NOUN
dti-1325	107	26	surface	surface	NOUN
dti-1325	107	27	and	and	CCONJ
dti-1325	107	28	forming	form	VERB
dti-1325	107	29	the	the	DET
dti-1325	107	30	complex	complex	NOUN
dti-1325	107	31	.	.	PUNCT
dti-1325	108	1	panel	panel	NOUN
dti-1325	108	2	b	b	PROPN
dti-1325	108	3	showed	show	VERB
dti-1325	108	4	that	that	SCONJ
dti-1325	108	5	in	in	ADP
dti-1325	108	6	the	the	DET
dti-1325	108	7	absence	absence	NOUN
dti-1325	108	8	of	of	ADP
dti-1325	108	9	mn2	mn2	NOUN
dti-1325	108	10	+	+	PROPN
dti-1325	108	11	,	,	PUNCT
dti-1325	108	12	the	the	DET
dti-1325	108	13	fitcpac-1	fitcpac-1	NUM
dti-1325	108	14	binding	bind	VERB
dti-1325	108	15	level	level	NOUN
dti-1325	108	16	(	(	PUNCT
dti-1325	108	17	calculated	calculate	VERB
dti-1325	108	18	as	as	ADP
dti-1325	108	19	percentage	percentage	NOUN
dti-1325	108	20	gated	gate	VERB
dti-1325	108	21	subset	subset	NOUN
dti-1325	108	22	)	)	PUNCT
dti-1325	108	23	was	be	AUX
dti-1325	108	24	also	also	ADV
dti-1325	108	25	similar	similar	ADJ
dti-1325	108	26	in	in	ADP
dti-1325	108	27	both	both	CCONJ
dti-1325	108	28	wild	wild	ADJ
dti-1325	108	29	type	type	NOUN
dti-1325	108	30	(	(	PUNCT
dti-1325	108	31	line	line	NOUN
dti-1325	108	32	2	2	NUM
dti-1325	108	33	)	)	PUNCT
dti-1325	108	34	and	and	CCONJ
dti-1325	108	35	αiib	αiib	ADJ
dti-1325	108	36	/	/	SYM
dti-1325	108	37	β3	β3	ADJ
dti-1325	108	38	-	-	PUNCT
dti-1325	108	39	mut	mut	NOUN
dti-1325	108	40	expressed	express	VERB
dti-1325	108	41	complexes	complex	NOUN
dti-1325	108	42	(	(	PUNCT
dti-1325	108	43	line	line	NOUN
dti-1325	108	44	3	3	NUM
dti-1325	108	45	)	)	PUNCT
dti-1325	108	46	.	.	PUNCT
dti-1325	109	1	however	however	ADV
dti-1325	109	2	,	,	PUNCT
dti-1325	109	3	in	in	ADP
dti-1325	109	4	panel	panel	NOUN
dti-1325	109	5	c	c	NOUN
dti-1325	109	6	,	,	PUNCT
dti-1325	109	7	following	follow	VERB
dti-1325	109	8	incubation	incubation	NOUN
dti-1325	109	9	with	with	ADP
dti-1325	109	10	2	2	NUM
dti-1325	109	11	mm	mm	NOUN
dti-1325	109	12	mn2	mn2	VERB
dti-1325	109	13	+	+	PROPN
dti-1325	109	14	,	,	PUNCT
dti-1325	109	15	the	the	DET
dti-1325	109	16	ability	ability	NOUN
dti-1325	109	17	to	to	PART
dti-1325	109	18	bind	bind	VERB
dti-1325	109	19	fitcpac-1	fitcpac-1	NOUN
dti-1325	109	20	increased	increase	VERB
dti-1325	109	21	in	in	ADP
dti-1325	109	22	the	the	DET
dti-1325	109	23	αiib	αiib	ADJ
dti-1325	109	24	/	/	SYM
dti-1325	109	25	β3	β3	ADJ
dti-1325	109	26	wild	wild	ADJ
dti-1325	109	27	type	type	NOUN
dti-1325	109	28	expressed	express	VERB
dti-1325	109	29	complex	complex	ADJ
dti-1325	109	30	(	(	PUNCT
dti-1325	109	31	line	line	NOUN
dti-1325	109	32	2	2	NUM
dti-1325	109	33	)	)	PUNCT
dti-1325	109	34	but	but	CCONJ
dti-1325	109	35	not	not	PART
dti-1325	109	36	the	the	DET
dti-1325	109	37	αiib	αiib	NOUN
dti-1325	109	38	/	/	SYM
dti-1325	109	39	β3mut	β3mut	PROPN
dti-1325	109	40	expressed	express	VERB
dti-1325	109	41	complex	complex	ADJ
dti-1325	109	42	(	(	PUNCT
dti-1325	109	43	line	line	NOUN
dti-1325	109	44	3	3	NUM
dti-1325	109	45	)	)	PUNCT
dti-1325	109	46	.	.	PUNCT
dti-1325	110	1	in	in	ADP
dti-1325	110	2	addition	addition	NOUN
dti-1325	110	3	to	to	ADP
dti-1325	110	4	the	the	DET
dti-1325	110	5	wild	wild	ADJ
dti-1325	110	6	type	type	NOUN
dti-1325	110	7	β3	β3	NOUN
dti-1325	110	8	and	and	CCONJ
dti-1325	110	9	β3	β3	ADJ
dti-1325	110	10	-	-	PUNCT
dti-1325	110	11	mut	mut	NOUN
dti-1325	110	12	,	,	PUNCT
dti-1325	110	13	we	we	PRON
dti-1325	110	14	have	have	AUX
dti-1325	110	15	constructed	construct	VERB
dti-1325	110	16	two	two	NUM
dti-1325	110	17	other	other	ADJ
dti-1325	110	18	mutants	mutant	NOUN
dti-1325	110	19	to	to	PART
dti-1325	110	20	examine	examine	VERB
dti-1325	110	21	the	the	DET
dti-1325	110	22	role	role	NOUN
dti-1325	110	23	of	of	ADP
dti-1325	110	24	the	the	DET
dti-1325	110	25	cysteine	cysteine	NOUN
dti-1325	110	26	residues	residue	NOUN
dti-1325	110	27	within	within	ADP
dti-1325	110	28	the	the	DET
dti-1325	110	29	peptide	peptide	NOUN
dti-1325	110	30	.	.	PUNCT
dti-1325	111	1	we	we	PRON
dti-1325	111	2	have	have	AUX
dti-1325	111	3	performed	perform	VERB
dti-1325	111	4	replacement	replacement	NOUN
dti-1325	111	5	of	of	ADP
dti-1325	111	6	cystine	cystine	NOUN
dti-1325	111	7	residues	residue	NOUN
dti-1325	111	8	(	(	PUNCT
dti-1325	111	9	499	499	NUM
dti-1325	111	10	and	and	CCONJ
dti-1325	111	11	512	512	NUM
dti-1325	111	12	)	)	PUNCT
dti-1325	111	13	one	one	NUM
dti-1325	111	14	at	at	ADP
dti-1325	111	15	a	a	DET
dti-1325	111	16	time	time	NOUN
dti-1325	111	17	with	with	ADP
dti-1325	111	18	alanine	alanine	NOUN
dti-1325	111	19	.	.	PUNCT
dti-1325	112	1	table	table	NOUN
dti-1325	112	2	1	1	NUM
dti-1325	112	3	shows	show	NOUN
dti-1325	112	4	following	follow	VERB
dti-1325	112	5	mn2	mn2	VERB
dti-1325	112	6	+	+	CCONJ
dti-1325	112	7	treatment	treatment	NOUN
dti-1325	112	8	,	,	PUNCT
dti-1325	112	9	the	the	DET
dti-1325	112	10	wild	wild	ADJ
dti-1325	112	11	type	type	NOUN
dti-1325	112	12	αiib	αiib	NOUN
dti-1325	112	13	/	/	SYM
dti-1325	112	14	β3	β3	PROPN
dti-1325	112	15	had	have	VERB
dti-1325	112	16	a	a	DET
dti-1325	112	17	higher	high	ADJ
dti-1325	112	18	percentage	percentage	NOUN
dti-1325	112	19	(	(	PUNCT
dti-1325	112	20	92	92	NUM
dti-1325	112	21	%	%	NOUN
dti-1325	112	22	)	)	PUNCT
dti-1325	112	23	of	of	ADP
dti-1325	112	24	pac-1	pac-1	VERB
dti-1325	112	25	binding	bind	VERB
dti-1325	112	26	,	,	PUNCT
dti-1325	112	27	compared	compare	VERB
dti-1325	112	28	to	to	ADP
dti-1325	112	29	a	a	DET
dti-1325	112	30	lower	low	ADJ
dti-1325	112	31	percentage	percentage	NOUN
dti-1325	112	32	with	with	ADP
dti-1325	112	33	the	the	DET
dti-1325	112	34	αiib	αiib	ADJ
dti-1325	112	35	/	/	SYM
dti-1325	112	36	β3	β3	ADJ
dti-1325	112	37	-	-	PUNCT
dti-1325	112	38	mut	mut	NOUN
dti-1325	112	39	(	(	PUNCT
dti-1325	112	40	61	61	NUM
dti-1325	112	41	%	%	NOUN
dti-1325	112	42	)	)	PUNCT
dti-1325	112	43	.	.	PUNCT
dti-1325	113	1	replacement	replacement	NOUN
dti-1325	113	2	of	of	ADP
dti-1325	113	3	either	either	PRON
dti-1325	113	4	499	499	NUM
dti-1325	113	5	(	(	PUNCT
dti-1325	113	6	89	89	NUM
dti-1325	113	7	%	%	NOUN
dti-1325	113	8	)	)	PUNCT
dti-1325	113	9	or	or	CCONJ
dti-1325	113	10	512	512	NUM
dti-1325	113	11	(	(	PUNCT
dti-1325	113	12	91	91	NUM
dti-1325	113	13	%	%	NOUN
dti-1325	113	14	)	)	PUNCT
dti-1325	113	15	with	with	ADP
dti-1325	113	16	ala	ala	PROPN
dti-1325	113	17	,	,	PUNCT
dti-1325	113	18	the	the	DET
dti-1325	113	19	binding	binding	NOUN
dti-1325	113	20	of	of	ADP
dti-1325	113	21	pac-1	pac-1	NOUN
dti-1325	113	22	did	do	AUX
dti-1325	113	23	not	not	PART
dti-1325	113	24	change	change	VERB
dti-1325	113	25	signifi	signifi	NOUN
dti-1325	113	26	cantly	cantly	ADV
dti-1325	113	27	compared	compare	VERB
dti-1325	113	28	to	to	ADP
dti-1325	113	29	wild	wild	ADJ
dti-1325	113	30	type	type	NOUN
dti-1325	113	31	.	.	PUNCT
dti-1325	114	1	the	the	DET
dti-1325	114	2	binding	binding	NOUN
dti-1325	114	3	of	of	ADP
dti-1325	114	4	pac-1	pac-1	NUM
dti-1325	114	5	by	by	ADP
dti-1325	114	6	gp	gp	NOUN
dti-1325	114	7	iib	iib	PROPN
dti-1325	114	8	/	/	SYM
dti-1325	114	9	iiia	iiia	NOUN
dti-1325	114	10	-	-	PUNCT
dti-1325	114	11	c499a	c499a	NOUN
dti-1325	114	12	(	(	PUNCT
dti-1325	114	13	89	89	NUM
dti-1325	114	14	%	%	NOUN
dti-1325	114	15	)	)	PUNCT
dti-1325	114	16	or	or	CCONJ
dti-1325	114	17	gp	gp	NOUN
dti-1325	114	18	iib	iib	PROPN
dti-1325	114	19	/	/	SYM
dti-1325	114	20	iiia	iiia	PROPN
dti-1325	114	21	-	-	PUNCT
dti-1325	114	22	c512a	c512a	PROPN
dti-1325	114	23	(	(	PUNCT
dti-1325	114	24	91	91	NUM
dti-1325	114	25	%	%	NOUN
dti-1325	114	26	)	)	PUNCT
dti-1325	114	27	did	do	AUX
dti-1325	114	28	not	not	PART
dti-1325	114	29	change	change	VERB
dti-1325	114	30	signifi	signifi	NOUN
dti-1325	114	31	cantly	cantly	ADV
dti-1325	114	32	compared	compare	VERB
dti-1325	114	33	to	to	ADP
dti-1325	114	34	wild	wild	ADJ
dti-1325	114	35	type	type	NOUN
dti-1325	114	36	.	.	PUNCT
dti-1325	115	1	however	however	ADV
dti-1325	115	2	,	,	PUNCT
dti-1325	115	3	these	these	DET
dti-1325	115	4	results	result	NOUN
dti-1325	115	5	do	do	AUX
dti-1325	115	6	indicate	indicate	VERB
dti-1325	115	7	that	that	PRON
dti-1325	115	8	mn2	mn2	VERB
dti-1325	115	9	+	+	CCONJ
dti-1325	115	10	could	could	AUX
dti-1325	115	11	not	not	PART
dti-1325	115	12	fully	fully	ADV
dti-1325	115	13	activate	activate	VERB
dti-1325	115	14	αiib	αiib	ADJ
dti-1325	115	15	/	/	SYM
dti-1325	115	16	β3	β3	ADJ
dti-1325	115	17	-	-	PUNCT
dti-1325	115	18	mutants	mutant	NOUN
dti-1325	115	19	resulting	result	VERB
dti-1325	115	20	in	in	ADP
dti-1325	115	21	fewer	few	ADJ
dti-1325	115	22	numbers	number	NOUN
dti-1325	115	23	of	of	ADP
dti-1325	115	24	the	the	DET
dti-1325	115	25	formation	formation	NOUN
dti-1325	115	26	of	of	ADP
dti-1325	115	27	the	the	DET
dti-1325	115	28	active	active	ADJ
dti-1325	115	29	complex	complex	NOUN
dti-1325	115	30	and	and	CCONJ
dti-1325	115	31	thus	thus	ADV
dti-1325	115	32	less	less	ADV
dti-1325	115	33	binding	binding	NOUN
dti-1325	115	34	of	of	ADP
dti-1325	115	35	fitc	fitc	NOUN
dti-1325	115	36	-	-	PUNCT
dti-1325	115	37	pac-1	pac-1	NOUN
dti-1325	115	38	.	.	PUNCT
dti-1325	116	1	we	we	PRON
dti-1325	116	2	have	have	AUX
dti-1325	116	3	assayed	assay	VERB
dti-1325	116	4	and	and	CCONJ
dti-1325	116	5	analyzed	analyze	VERB
dti-1325	116	6	the	the	DET
dti-1325	116	7	effect	effect	NOUN
dti-1325	116	8	of	of	ADP
dti-1325	116	9	both	both	CCONJ
dti-1325	116	10	the	the	DET
dti-1325	116	11	p4	p4	ADJ
dti-1325	116	12	and	and	CCONJ
dti-1325	116	13	p4s	p4s	NOUN
dti-1325	116	14	peptides	peptide	NOUN
dti-1325	116	15	to	to	ADP
dti-1325	116	16	the	the	DET
dti-1325	116	17	mn2	mn2	ADJ
dti-1325	116	18	+	+	ADJ
dti-1325	116	19	-activated	-activated	ADJ
dti-1325	116	20	αiib	αiib	ADJ
dti-1325	116	21	/	/	SYM
dti-1325	116	22	β3	β3	ADJ
dti-1325	116	23	complex	complex	NOUN
dti-1325	116	24	by	by	ADP
dti-1325	116	25	measuring	measure	VERB
dti-1325	116	26	the	the	DET
dti-1325	116	27	binding	binding	NOUN
dti-1325	116	28	of	of	ADP
dti-1325	116	29	fitc	fitc	NOUN
dti-1325	116	30	-	-	PUNCT
dti-1325	116	31	pac-1	pac-1	NOUN
dti-1325	116	32	.	.	PUNCT
dti-1325	117	1	figure	figure	NOUN
dti-1325	117	2	4	4	NUM
dti-1325	117	3	shows	show	VERB
dti-1325	117	4	the	the	DET
dti-1325	117	5	effects	effect	NOUN
dti-1325	117	6	of	of	ADP
dti-1325	117	7	the	the	DET
dti-1325	117	8	addition	addition	NOUN
dti-1325	117	9	of	of	ADP
dti-1325	117	10	the	the	DET
dti-1325	117	11	p4	p4	ADJ
dti-1325	117	12	peptide	peptide	NOUN
dti-1325	117	13	.	.	PUNCT
dti-1325	118	1	panel	panel	NOUN
dti-1325	118	2	a	a	DET
dti-1325	118	3	shows	show	VERB
dti-1325	118	4	the	the	DET
dti-1325	118	5	control	control	NOUN
dti-1325	118	6	cho	cho	PROPN
dti-1325	118	7	cells	cell	NOUN
dti-1325	118	8	while	while	SCONJ
dti-1325	118	9	panel	panel	NOUN
dti-1325	118	10	b	b	PROPN
dti-1325	118	11	represents	represent	VERB
dti-1325	118	12	the	the	DET
dti-1325	118	13	fitcpac-1	fitcpac-1	NOUN
dti-1325	118	14	bound	bind	VERB
dti-1325	118	15	to	to	PART
dti-1325	118	16	mn2	mn2	VERB
dti-1325	118	17	+	+	VERB
dti-1325	118	18	-activated	-activate	VERB
dti-1325	118	19	αiib	αiib	ADJ
dti-1325	118	20	/	/	SYM
dti-1325	118	21	β3	β3	NOUN
dti-1325	118	22	complex	complex	NOUN
dti-1325	118	23	.	.	PUNCT
dti-1325	119	1	when	when	SCONJ
dti-1325	119	2	cells	cell	NOUN
dti-1325	119	3	are	be	AUX
dti-1325	119	4	pre	pre	ADJ
dti-1325	119	5	-	-	VERB
dti-1325	119	6	incubated	incubate	VERB
dti-1325	119	7	with	with	ADP
dti-1325	119	8	p4	p4	ADJ
dti-1325	119	9	and	and	CCONJ
dti-1325	119	10	mn2	mn2	VERB
dti-1325	119	11	+	+	PROPN
dti-1325	119	12	,	,	PUNCT
dti-1325	119	13	the	the	DET
dti-1325	119	14	binding	binding	NOUN
dti-1325	119	15	of	of	ADP
dti-1325	119	16	fitc	fitc	NOUN
dti-1325	119	17	-	-	PUNCT
dti-1325	119	18	pac-1	pac-1	NOUN
dti-1325	119	19	is	be	AUX
dti-1325	119	20	inhibited	inhibit	VERB
dti-1325	119	21	in	in	ADP
dti-1325	119	22	a	a	DET
dti-1325	119	23	dosedependent	dosedependent	NOUN
dti-1325	119	24	manner	manner	NOUN
dti-1325	119	25	.	.	PUNCT
dti-1325	120	1	the	the	DET
dti-1325	120	2	percentage	percentage	NOUN
dti-1325	120	3	of	of	ADP
dti-1325	120	4	inhibition	inhibition	NOUN
dti-1325	120	5	is	be	AUX
dti-1325	120	6	figure	figure	NOUN
dti-1325	120	7	1	1	NUM
dti-1325	120	8	.	.	PUNCT
dti-1325	120	9	inhibition	inhibition	NOUN
dti-1325	120	10	of	of	ADP
dti-1325	120	11	[	[	X
dti-1325	120	12	3h]-fibrinogen	3h]-fibrinogen	NUM
dti-1325	120	13	binding	bind	VERB
dti-1325	120	14	to	to	ADP
dti-1325	120	15	human	human	ADJ
dti-1325	120	16	platelets	platelet	NOUN
dti-1325	120	17	by	by	ADP
dti-1325	120	18	p4	p4	ADJ
dti-1325	120	19	and	and	CCONJ
dti-1325	120	20	scrambled	scramble	VERB
dti-1325	120	21	p4	p4	ADJ
dti-1325	120	22	(	(	PUNCT
dti-1325	120	23	p4s	p4s	NOUN
dti-1325	120	24	)	)	PUNCT
dti-1325	120	25	peptides	peptide	NOUN
dti-1325	120	26	.	.	PUNCT
dti-1325	121	1	binding	bind	VERB
dti-1325	121	2	assay	assay	NOUN
dti-1325	121	3	of	of	ADP
dti-1325	121	4	[	[	X
dti-1325	121	5	3h]-fi	3h]-fi	NUM
dti-1325	121	6	brinogen	brinogen	NOUN
dti-1325	121	7	to	to	ADP
dti-1325	121	8	human	human	ADJ
dti-1325	121	9	platelets	platelet	NOUN
dti-1325	121	10	in	in	ADP
dti-1325	121	11	the	the	DET
dti-1325	121	12	presence	presence	NOUN
dti-1325	121	13	of	of	ADP
dti-1325	121	14	various	various	ADJ
dti-1325	121	15	amounts	amount	NOUN
dti-1325	121	16	of	of	ADP
dti-1325	121	17	p4	p4	ADJ
dti-1325	121	18	(	(	PUNCT
dti-1325	121	19	line	line	NOUN
dti-1325	121	20	with	with	ADP
dti-1325	121	21	fi	fi	NOUN
dti-1325	121	22	lled	lle	VERB
dti-1325	121	23	diamonds	diamond	NOUN
dti-1325	121	24	)	)	PUNCT
dti-1325	121	25	and	and	CCONJ
dti-1325	121	26	scrambled	scramble	VERB
dti-1325	121	27	p4	p4	ADJ
dti-1325	121	28	peptides	peptide	NOUN
dti-1325	121	29	(	(	PUNCT
dti-1325	121	30	line	line	NOUN
dti-1325	121	31	with	with	ADP
dti-1325	121	32	closed	closed	ADJ
dti-1325	121	33	squares	square	NOUN
dti-1325	121	34	)	)	PUNCT
dti-1325	121	35	0–80	0–80	PROPN
dti-1325	121	36	µm	µm	NOUN
dti-1325	121	37	for	for	ADP
dti-1325	121	38	30	30	NUM
dti-1325	121	39	minutes	minute	NOUN
dti-1325	121	40	at	at	ADP
dti-1325	121	41	room	room	NOUN
dti-1325	121	42	temperature	temperature	NOUN
dti-1325	121	43	and	and	CCONJ
dti-1325	121	44	assessed	assess	VERB
dti-1325	121	45	for	for	ADP
dti-1325	121	46	radioactivity	radioactivity	NOUN
dti-1325	121	47	.	.	PUNCT
dti-1325	122	1	the	the	DET
dti-1325	122	2	data	datum	NOUN
dti-1325	122	3	expressed	express	VERB
dti-1325	122	4	is	be	AUX
dti-1325	122	5	an	an	DET
dti-1325	122	6	average	average	NOUN
dti-1325	122	7	of	of	ADP
dti-1325	122	8	duplicates	duplicate	NOUN
dti-1325	122	9	per	per	ADP
dti-1325	122	10	experiment	experiment	NOUN
dti-1325	122	11	and	and	CCONJ
dti-1325	122	12	repeated	repeat	VERB
dti-1325	122	13	three	three	NUM
dti-1325	122	14	times	time	NOUN
dti-1325	122	15	with	with	ADP
dti-1325	122	16	similar	similar	ADJ
dti-1325	122	17	results	result	NOUN
dti-1325	122	18	.	.	PUNCT
dti-1325	123	1	a	a	DET
dti-1325	123	2	representative	representative	ADJ
dti-1325	123	3	study	study	NOUN
dti-1325	123	4	is	be	AUX
dti-1325	123	5	shown	show	VERB
dti-1325	123	6	.	.	PUNCT
dti-1325	124	1	72	72	NUM
dti-1325	124	2	woo	woo	NOUN
dti-1325	124	3	-	-	PUNCT
dti-1325	124	4	rasberry	rasberry	NOUN
dti-1325	124	5	and	and	CCONJ
dti-1325	124	6	chiang	chiang	PROPN
dti-1325	124	7	drug	drug	PROPN
dti-1325	124	8	target	target	NOUN
dti-1325	124	9	insights	insight	NOUN
dti-1325	124	10	2008:3	2008:3	NUM
dti-1325	124	11	28	28	NUM
dti-1325	124	12	%	%	NOUN
dti-1325	124	13	(	(	PUNCT
dti-1325	124	14	panel	panel	NOUN
dti-1325	124	15	c	c	NOUN
dti-1325	124	16	,	,	PUNCT
dti-1325	124	17	60	60	NUM
dti-1325	124	18	µm	µm	NOUN
dti-1325	124	19	)	)	PUNCT
dti-1325	124	20	and	and	CCONJ
dti-1325	124	21	60	60	NUM
dti-1325	124	22	%	%	NOUN
dti-1325	124	23	(	(	PUNCT
dti-1325	124	24	panel	panel	NOUN
dti-1325	124	25	d	d	PROPN
dti-1325	124	26	,	,	PUNCT
dti-1325	124	27	80	80	NUM
dti-1325	124	28	µm	µm	NOUN
dti-1325	124	29	)	)	PUNCT
dti-1325	124	30	,	,	PUNCT
dti-1325	124	31	respectively	respectively	ADV
dti-1325	124	32	.	.	PUNCT
dti-1325	125	1	the	the	DET
dti-1325	125	2	concentration	concentration	NOUN
dti-1325	125	3	of	of	ADP
dti-1325	125	4	peptide	peptide	NOUN
dti-1325	125	5	required	require	VERB
dti-1325	125	6	for	for	ADP
dti-1325	125	7	inhibition	inhibition	NOUN
dti-1325	125	8	was	be	AUX
dti-1325	125	9	similar	similar	ADJ
dti-1325	125	10	to	to	ADP
dti-1325	125	11	that	that	PRON
dti-1325	125	12	used	use	VERB
dti-1325	125	13	in	in	ADP
dti-1325	125	14	washed	wash	VERB
dti-1325	125	15	human	human	ADJ
dti-1325	125	16	platelets	platelet	NOUN
dti-1325	125	17	(	(	PUNCT
dti-1325	125	18	schwartz	schwartz	PROPN
dti-1325	125	19	et	et	PROPN
dti-1325	125	20	al	al	PROPN
dti-1325	125	21	.	.	PROPN
dti-1325	125	22	1995	1995	NUM
dti-1325	125	23	)	)	PUNCT
dti-1325	125	24	.	.	PUNCT
dti-1325	126	1	the	the	DET
dti-1325	126	2	p4s	p4s	PROPN
dti-1325	126	3	did	do	AUX
dti-1325	126	4	not	not	PART
dti-1325	126	5	show	show	VERB
dti-1325	126	6	any	any	DET
dti-1325	126	7	signifi	signifi	NOUN
dti-1325	126	8	ca	can	AUX
dti-1325	126	9	nt	not	PART
dti-1325	126	10	inhibition	inhibition	VERB
dti-1325	126	11	on	on	ADP
dti-1325	126	12	the	the	DET
dti-1325	126	13	binding	binding	NOUN
dti-1325	126	14	to	to	ADP
dti-1325	126	15	the	the	DET
dti-1325	126	16	mn2	mn2	ADJ
dti-1325	126	17	+	+	ADJ
dti-1325	126	18	-activated	-activated	ADJ
dti-1325	126	19	αiib	αiib	ADJ
dti-1325	126	20	/	/	SYM
dti-1325	126	21	β3	β3	ADJ
dti-1325	126	22	complex	complex	NOUN
dti-1325	126	23	(	(	PUNCT
dti-1325	126	24	data	datum	NOUN
dti-1325	126	25	not	not	PART
dti-1325	126	26	shown	show	VERB
dti-1325	126	27	)	)	PUNCT
dti-1325	126	28	.	.	PUNCT
dti-1325	127	1	we	we	PRON
dti-1325	127	2	have	have	AUX
dti-1325	127	3	established	establish	VERB
dti-1325	127	4	the	the	DET
dti-1325	127	5	optimal	optimal	ADJ
dti-1325	127	6	conditions	condition	NOUN
dti-1325	127	7	for	for	ADP
dti-1325	127	8	[	[	X
dti-1325	127	9	3h]-fi	3h]-fi	NUM
dti-1325	127	10	brinogen	brinogen	NOUN
dti-1325	127	11	binding	bind	VERB
dti-1325	127	12	assays	assay	NOUN
dti-1325	127	13	[	[	X
dti-1325	127	14	fi	fi	X
dti-1325	127	15	brinogen	brinogen	PROPN
dti-1325	127	16	fi	fi	NOUN
dti-1325	127	17	nal	nal	ADJ
dti-1325	127	18	concentration	concentration	NOUN
dti-1325	127	19	(	(	PUNCT
dti-1325	127	20	80	80	NUM
dti-1325	127	21	nm	nm	NOUN
dti-1325	127	22	,	,	PUNCT
dti-1325	127	23	cell	cell	NOUN
dti-1325	127	24	number	number	NOUN
dti-1325	127	25	(	(	PUNCT
dti-1325	127	26	5	5	NUM
dti-1325	127	27	×	×	NOUN
dti-1325	127	28	106	106	NUM
dti-1325	127	29	)	)	PUNCT
dti-1325	127	30	,	,	PUNCT
dti-1325	127	31	temperature	temperature	NOUN
dti-1325	127	32	,	,	PUNCT
dti-1325	127	33	and	and	CCONJ
dti-1325	127	34	incubation	incubation	NOUN
dti-1325	127	35	time	time	NOUN
dti-1325	127	36	(	(	PUNCT
dti-1325	127	37	60	60	NUM
dti-1325	127	38	minutes	minute	NOUN
dti-1325	127	39	)	)	PUNCT
dti-1325	127	40	]	]	PUNCT
dti-1325	127	41	to	to	PART
dti-1325	127	42	determine	determine	VERB
dti-1325	127	43	the	the	DET
dti-1325	127	44	effects	effect	NOUN
dti-1325	127	45	of	of	ADP
dti-1325	127	46	the	the	DET
dti-1325	127	47	p4	p4	ADJ
dti-1325	127	48	and	and	CCONJ
dti-1325	127	49	p4s	p4s	NOUN
dti-1325	127	50	peptides	peptide	NOUN
dti-1325	127	51	.	.	PUNCT
dti-1325	128	1	we	we	PRON
dti-1325	128	2	investigated	investigate	VERB
dti-1325	128	3	the	the	DET
dti-1325	128	4	ability	ability	NOUN
dti-1325	128	5	of	of	ADP
dti-1325	128	6	the	the	DET
dti-1325	128	7	p4	p4	ADJ
dti-1325	128	8	peptide	peptide	NOUN
dti-1325	128	9	to	to	PART
dti-1325	128	10	inhibit	inhibit	VERB
dti-1325	128	11	fibrinogen	fibrinogen	NOUN
dti-1325	128	12	binding	bind	VERB
dti-1325	128	13	to	to	PART
dti-1325	128	14	αiib	αiib	VERB
dti-1325	128	15	/	/	SYM
dti-1325	128	16	β3	β3	ADJ
dti-1325	128	17	in	in	ADP
dti-1325	128	18	the	the	DET
dti-1325	128	19	presence	presence	NOUN
dti-1325	128	20	of	of	ADP
dti-1325	128	21	2	2	NUM
dti-1325	128	22	mm	mm	NOUN
dti-1325	128	23	mn2	mn2	VERB
dti-1325	128	24	+	+	PROPN
dti-1325	128	25	.	.	PUNCT
dti-1325	129	1	the	the	DET
dti-1325	129	2	p4s	p4s	PROPN
dti-1325	129	3	peptide	peptide	NOUN
dti-1325	129	4	was	be	AUX
dti-1325	129	5	used	use	VERB
dti-1325	129	6	as	as	ADP
dti-1325	129	7	the	the	DET
dti-1325	129	8	control	control	NOUN
dti-1325	129	9	in	in	ADP
dti-1325	129	10	the	the	DET
dti-1325	129	11	[	[	X
dti-1325	129	12	3h]-fi	3h]-fi	NUM
dti-1325	129	13	brinogen	brinogen	NOUN
dti-1325	129	14	binding	bind	VERB
dti-1325	129	15	assays	assay	NOUN
dti-1325	129	16	.	.	PUNCT
dti-1325	130	1	the	the	DET
dti-1325	130	2	addition	addition	NOUN
dti-1325	130	3	of	of	ADP
dti-1325	130	4	p4	p4	ADJ
dti-1325	130	5	peptide	peptide	NOUN
dti-1325	130	6	decreased	decrease	VERB
dti-1325	130	7	the	the	DET
dti-1325	130	8	amount	amount	NOUN
dti-1325	130	9	of	of	ADP
dti-1325	130	10	fibrinogen	fibrinogen	NOUN
dti-1325	130	11	binding	bind	VERB
dti-1325	130	12	to	to	ADP
dti-1325	130	13	the	the	DET
dti-1325	130	14	mn2+activated	mn2+activate	VERB
dti-1325	130	15	αiib	αiib	ADJ
dti-1325	130	16	/	/	SYM
dti-1325	130	17	β3	β3	ADJ
dti-1325	130	18	complex	complex	NOUN
dti-1325	130	19	in	in	ADP
dti-1325	130	20	a	a	DET
dti-1325	130	21	dose	dose	NOUN
dti-1325	130	22	-	-	PUNCT
dti-1325	130	23	dependent	dependent	ADJ
dti-1325	130	24	fashion	fashion	NOUN
dti-1325	130	25	(	(	PUNCT
dti-1325	130	26	fig	fig	NOUN
dti-1325	130	27	.	.	PUNCT
dti-1325	131	1	5	5	NUM
dti-1325	131	2	,	,	PUNCT
dti-1325	131	3	line	line	NOUN
dti-1325	131	4	with	with	ADP
dti-1325	131	5	open	open	ADJ
dti-1325	131	6	circles	circle	NOUN
dti-1325	131	7	)	)	PUNCT
dti-1325	131	8	,	,	PUNCT
dti-1325	131	9	as	as	SCONJ
dti-1325	131	10	the	the	DET
dti-1325	131	11	peptide	peptide	NOUN
dti-1325	131	12	dose	dose	NOUN
dti-1325	131	13	increased	increase	VERB
dti-1325	131	14	,	,	PUNCT
dti-1325	131	15	the	the	DET
dti-1325	131	16	amount	amount	NOUN
dti-1325	131	17	of	of	ADP
dti-1325	131	18	fi	fi	NOUN
dti-1325	131	19	brinogen	brinogen	NOUN
dti-1325	131	20	binding	bind	VERB
dti-1325	131	21	to	to	ADP
dti-1325	131	22	the	the	DET
dti-1325	131	23	cell	cell	NOUN
dti-1325	131	24	surface	surface	NOUN
dti-1325	131	25	decreased	decrease	VERB
dti-1325	131	26	.	.	PUNCT
dti-1325	132	1	the	the	DET
dti-1325	132	2	scrambled	scramble	VERB
dti-1325	132	3	peptide	peptide	NOUN
dti-1325	132	4	,	,	PUNCT
dti-1325	132	5	p4s	p4s	PROPN
dti-1325	132	6	,	,	PUNCT
dti-1325	132	7	did	do	AUX
dti-1325	132	8	not	not	PART
dti-1325	132	9	inhibit	inhibit	VERB
dti-1325	132	10	the	the	DET
dti-1325	132	11	fi	fi	NOUN
dti-1325	132	12	brinogen	brinogen	NOUN
dti-1325	132	13	binding	bind	VERB
dti-1325	132	14	signifi	signifi	NOUN
dti-1325	132	15	cantly	cantly	ADV
dti-1325	132	16	(	(	PUNCT
dti-1325	132	17	fig	fig	NOUN
dti-1325	132	18	.	.	PUNCT
dti-1325	133	1	5	5	NUM
dti-1325	133	2	,	,	PUNCT
dti-1325	133	3	line	line	NOUN
dti-1325	133	4	with	with	ADP
dti-1325	133	5	fi	fi	NOUN
dti-1325	133	6	lled	lle	VERB
dti-1325	133	7	squares	square	NOUN
dti-1325	133	8	)	)	PUNCT
dti-1325	133	9	,	,	PUNCT
dti-1325	133	10	indicating	indicate	VERB
dti-1325	133	11	that	that	SCONJ
dti-1325	133	12	the	the	DET
dti-1325	133	13	order	order	NOUN
dti-1325	133	14	of	of	ADP
dti-1325	133	15	amino	amino	NOUN
dti-1325	133	16	acid	acid	NOUN
dti-1325	133	17	residues	residue	NOUN
dti-1325	133	18	in	in	ADP
dti-1325	133	19	the	the	DET
dti-1325	133	20	p4	p4	ADJ
dti-1325	133	21	peptide	peptide	NOUN
dti-1325	133	22	sequence	sequence	NOUN
dti-1325	133	23	is	be	AUX
dti-1325	133	24	important	important	ADJ
dti-1325	133	25	for	for	ADP
dti-1325	133	26	inhibiting	inhibit	VERB
dti-1325	133	27	αiib	αiib	ADJ
dti-1325	133	28	/	/	SYM
dti-1325	133	29	β3	β3	ADJ
dti-1325	133	30	complex	complex	ADJ
dti-1325	133	31	formation	formation	NOUN
dti-1325	133	32	,	,	PUNCT
dti-1325	133	33	thus	thus	ADV
dti-1325	133	34	inhibiting	inhibit	VERB
dti-1325	133	35	fi	fi	NOUN
dti-1325	133	36	brinogen	brinogen	NOUN
dti-1325	133	37	binding	binding	NOUN
dti-1325	133	38	.	.	PUNCT
dti-1325	134	1	although	although	SCONJ
dti-1325	134	2	,	,	PUNCT
dti-1325	134	3	this	this	DET
dti-1325	134	4	experiment	experiment	NOUN
dti-1325	134	5	may	may	AUX
dti-1325	134	6	not	not	PART
dti-1325	134	7	represent	represent	VERB
dti-1325	134	8	the	the	DET
dti-1325	134	9	cellular	cellular	ADJ
dti-1325	134	10	physiology	physiology	NOUN
dti-1325	134	11	and	and	CCONJ
dti-1325	134	12	biochemistry	biochemistry	NOUN
dti-1325	134	13	of	of	ADP
dti-1325	134	14	human	human	ADJ
dti-1325	134	15	platelets	platelet	NOUN
dti-1325	134	16	,	,	PUNCT
dti-1325	134	17	it	it	PRON
dti-1325	134	18	may	may	AUX
dti-1325	134	19	be	be	AUX
dti-1325	134	20	another	another	DET
dti-1325	134	21	useful	useful	ADJ
dti-1325	134	22	tool	tool	NOUN
dti-1325	134	23	to	to	PART
dti-1325	134	24	study	study	VERB
dti-1325	134	25	the	the	DET
dti-1325	134	26	interaction	interaction	NOUN
dti-1325	134	27	processes	process	NOUN
dti-1325	134	28	.	.	PUNCT
dti-1325	135	1	figure	figure	NOUN
dti-1325	135	2	2	2	NUM
dti-1325	135	3	.	.	PUNCT
dti-1325	136	1	immunoblots	immunoblot	NOUN
dti-1325	136	2	of	of	ADP
dti-1325	136	3	wild	wild	ADJ
dti-1325	136	4	type	type	NOUN
dti-1325	136	5	αiib	αiib	NOUN
dti-1325	136	6	,	,	PUNCT
dti-1325	136	7	β3	β3	VERB
dti-1325	136	8	and	and	CCONJ
dti-1325	136	9	β3	β3	ADJ
dti-1325	136	10	-	-	PUNCT
dti-1325	136	11	mut	mut	NOUN
dti-1325	136	12	proteins	protein	NOUN
dti-1325	136	13	.	.	PUNCT
dti-1325	137	1	the	the	DET
dti-1325	137	2	wild	wild	ADJ
dti-1325	137	3	type	type	NOUN
dti-1325	137	4	cdnas	cdna	NOUN
dti-1325	137	5	of	of	ADP
dti-1325	137	6	αiib	αiib	NOUN
dti-1325	137	7	and	and	CCONJ
dti-1325	137	8	β3	β3	ADJ
dti-1325	137	9	as	as	ADV
dti-1325	137	10	well	well	ADV
dti-1325	137	11	as	as	ADP
dti-1325	137	12	αiib	αiib	NOUN
dti-1325	137	13	/	/	SYM
dti-1325	137	14	β3	β3	ADJ
dti-1325	137	15	-	-	PUNCT
dti-1325	137	16	mut	mut	NOUN
dti-1325	137	17	were	be	AUX
dti-1325	137	18	cotransfected	cotransfecte	VERB
dti-1325	137	19	into	into	ADP
dti-1325	137	20	cho	cho	NOUN
dti-1325	137	21	cells	cell	NOUN
dti-1325	137	22	allowing	allow	VERB
dti-1325	137	23	for	for	ADP
dti-1325	137	24	transgene	transgene	ADJ
dti-1325	137	25	expression	expression	NOUN
dti-1325	137	26	48	48	NUM
dti-1325	137	27	hours	hour	NOUN
dti-1325	137	28	following	follow	VERB
dti-1325	137	29	transfection	transfection	NOUN
dti-1325	137	30	.	.	PUNCT
dti-1325	138	1	the	the	DET
dti-1325	138	2	cells	cell	NOUN
dti-1325	138	3	are	be	AUX
dti-1325	138	4	harvested	harvest	VERB
dti-1325	138	5	,	,	PUNCT
dti-1325	138	6	washed	wash	VERB
dti-1325	138	7	,	,	PUNCT
dti-1325	138	8	lysed	lyse	VERB
dti-1325	138	9	,	,	PUNCT
dti-1325	138	10	and	and	CCONJ
dti-1325	138	11	protein	protein	NOUN
dti-1325	138	12	concentration	concentration	NOUN
dti-1325	138	13	determined	determine	VERB
dti-1325	138	14	.	.	PUNCT
dti-1325	139	1	equal	equal	ADJ
dti-1325	139	2	amounts	amount	NOUN
dti-1325	139	3	of	of	ADP
dti-1325	139	4	protein	protein	NOUN
dti-1325	139	5	were	be	AUX
dti-1325	139	6	separated	separate	VERB
dti-1325	139	7	by	by	ADP
dti-1325	139	8	sds	sds	PROPN
dti-1325	139	9	-	-	PUNCT
dti-1325	139	10	page	page	NOUN
dti-1325	139	11	and	and	CCONJ
dti-1325	139	12	electroblotted	electroblotte	VERB
dti-1325	139	13	for	for	ADP
dti-1325	139	14	immunoblot	immunoblot	NOUN
dti-1325	139	15	analysis	analysis	NOUN
dti-1325	139	16	.	.	PUNCT
dti-1325	140	1	panel	panel	NOUN
dti-1325	140	2	a	a	PRON
dti-1325	140	3	and	and	CCONJ
dti-1325	140	4	b	b	NOUN
dti-1325	140	5	are	be	AUX
dti-1325	140	6	10	10	NUM
dti-1325	140	7	%	%	NOUN
dti-1325	140	8	and	and	CCONJ
dti-1325	140	9	7.5	7.5	NUM
dti-1325	140	10	%	%	NOUN
dti-1325	140	11	reduced	reduce	VERB
dti-1325	140	12	sds	sds	PROPN
dti-1325	140	13	-	-	PUNCT
dti-1325	140	14	page	page	NOUN
dti-1325	140	15	,	,	PUNCT
dti-1325	140	16	respectively	respectively	ADV
dti-1325	140	17	.	.	PUNCT
dti-1325	141	1	monoclonal	monoclonal	NOUN
dti-1325	141	2	antibodies	antibody	NOUN
dti-1325	141	3	(	(	PUNCT
dti-1325	141	4	anti	anti	ADJ
dti-1325	141	5	-	-	ADJ
dti-1325	141	6	αiib	αiib	ADJ
dti-1325	141	7	-	-	PUNCT
dti-1325	141	8	panel	panel	NOUN
dti-1325	141	9	a	a	PRON
dti-1325	141	10	and	and	CCONJ
dti-1325	141	11	anti	anti	ADJ
dti-1325	141	12	β3	β3	ADJ
dti-1325	141	13	-	-	PUNCT
dti-1325	141	14	panel	panel	NOUN
dti-1325	141	15	b	b	NOUN
dti-1325	141	16	,	,	PUNCT
dti-1325	141	17	preabsorbed	preabsorbe	VERB
dti-1325	141	18	with	with	ADP
dti-1325	141	19	cho	cho	NOUN
dti-1325	141	20	cells	cell	NOUN
dti-1325	141	21	)	)	PUNCT
dti-1325	141	22	are	be	AUX
dti-1325	141	23	used	use	VERB
dti-1325	141	24	to	to	PART
dti-1325	141	25	detect	detect	VERB
dti-1325	141	26	the	the	DET
dti-1325	141	27	presence	presence	NOUN
dti-1325	141	28	of	of	ADP
dti-1325	141	29	each	each	DET
dti-1325	141	30	integrin	integrin	NOUN
dti-1325	141	31	.	.	PUNCT
dti-1325	142	1	lane	lane	PROPN
dti-1325	142	2	1	1	NUM
dti-1325	142	3	,	,	PUNCT
dti-1325	142	4	mock	mock	ADJ
dti-1325	142	5	control	control	NOUN
dti-1325	142	6	;	;	PUNCT
dti-1325	142	7	lane	lane	NOUN
dti-1325	142	8	2	2	NUM
dti-1325	142	9	,	,	PUNCT
dti-1325	142	10	co	co	VERB
dti-1325	142	11	-	-	ADJ
dti-1325	142	12	transfected	transfecte	VERB
dti-1325	142	13	cells	cell	NOUN
dti-1325	142	14	of	of	ADP
dti-1325	142	15	wild	wild	ADJ
dti-1325	142	16	type	type	NOUN
dti-1325	142	17	αiib	αiib	ADJ
dti-1325	142	18	/	/	SYM
dti-1325	142	19	β3	β3	ADJ
dti-1325	142	20	cdnas	cdna	NOUN
dti-1325	142	21	;	;	PUNCT
dti-1325	142	22	lane	lane	NOUN
dti-1325	142	23	3	3	NUM
dti-1325	142	24	,	,	PUNCT
dti-1325	142	25	co	co	VERB
dti-1325	142	26	-	-	ADJ
dti-1325	142	27	transfected	transfecte	VERB
dti-1325	142	28	cells	cell	NOUN
dti-1325	142	29	of	of	ADP
dti-1325	142	30	wild	wild	ADJ
dti-1325	142	31	αiib	αiib	ADJ
dti-1325	142	32	and	and	CCONJ
dti-1325	142	33	β3	β3	ADJ
dti-1325	142	34	-	-	PUNCT
dti-1325	142	35	mut	mut	NOUN
dti-1325	142	36	cdnas	cdna	NOUN
dti-1325	142	37	.	.	PUNCT
dti-1325	143	1	arrows	arrow	NOUN
dti-1325	143	2	indicates	indicate	VERB
dti-1325	143	3	αiib	αiib	ADJ
dti-1325	143	4	protein	protein	NOUN
dti-1325	143	5	in	in	ADP
dti-1325	143	6	panel	panel	NOUN
dti-1325	143	7	a	a	PRON
dti-1325	143	8	and	and	CCONJ
dti-1325	143	9	β3	β3	VERB
dti-1325	143	10	protein	protein	NOUN
dti-1325	143	11	in	in	ADP
dti-1325	143	12	panel	panel	NOUN
dti-1325	143	13	b.	b.	PROPN
dti-1325	143	14	figure	figure	NOUN
dti-1325	143	15	3	3	NUM
dti-1325	143	16	.	.	PUNCT
dti-1325	143	17	analysis	analysis	NOUN
dti-1325	143	18	of	of	ADP
dti-1325	143	19	expressed	express	VERB
dti-1325	143	20	αiib	αiib	ADJ
dti-1325	143	21	/	/	SYM
dti-1325	143	22	β3	β3	ADJ
dti-1325	143	23	wild	wild	ADJ
dti-1325	143	24	type	type	NOUN
dti-1325	143	25	and	and	CCONJ
dti-1325	143	26	αiib	αiib	ADJ
dti-1325	143	27	/	/	SYM
dti-1325	143	28	β3	β3	ADJ
dti-1325	143	29	-	-	PUNCT
dti-1325	143	30	mut	mut	NOUN
dti-1325	143	31	by	by	ADP
dti-1325	143	32	fl	fl	INTJ
dti-1325	143	33	ow	ow	PROPN
dti-1325	143	34	cytometry	cytometry	PROPN
dti-1325	143	35	.	.	PUNCT
dti-1325	144	1	stable	stable	ADJ
dti-1325	144	2	lines	line	NOUN
dti-1325	144	3	expressing	express	VERB
dti-1325	144	4	wild	wild	ADJ
dti-1325	144	5	type	type	NOUN
dti-1325	144	6	or	or	CCONJ
dti-1325	144	7	mutant	mutant	ADJ
dti-1325	144	8	β3	β3	ADJ
dti-1325	144	9	and	and	CCONJ
dti-1325	144	10	wild	wild	ADJ
dti-1325	144	11	type	type	NOUN
dti-1325	144	12	αiib	αiib	NOUN
dti-1325	144	13	were	be	AUX
dti-1325	144	14	incubated	incubate	VERB
dti-1325	144	15	with	with	ADP
dti-1325	144	16	different	different	ADJ
dti-1325	144	17	monoclonal	monoclonal	NOUN
dti-1325	144	18	reagents	reagent	NOUN
dti-1325	144	19	.	.	PUNCT
dti-1325	145	1	panel	panel	NOUN
dti-1325	145	2	a	a	DET
dti-1325	145	3	:	:	PUNCT
dti-1325	145	4	monoclonal	monoclonal	NOUN
dti-1325	145	5	antibody	antibody	NOUN
dti-1325	145	6	ap2	ap2	PROPN
dti-1325	145	7	labeled	label	VERB
dti-1325	145	8	with	with	ADP
dti-1325	145	9	fl	fl	PROPN
dti-1325	145	10	uorescent	uorescent	ADJ
dti-1325	145	11	dye	dye	NOUN
dti-1325	145	12	alexa	alexa	NOUN
dti-1325	145	13	fluor	fluor	NOUN
dti-1325	145	14	647	647	NUM
dti-1325	145	15	binds	bind	VERB
dti-1325	145	16	to	to	ADP
dti-1325	145	17	the	the	DET
dti-1325	145	18	αiib	αiib	ADJ
dti-1325	145	19	/	/	SYM
dti-1325	145	20	β3	β3	ADJ
dti-1325	145	21	inactive	inactive	ADJ
dti-1325	145	22	complex	complex	NOUN
dti-1325	145	23	.	.	PUNCT
dti-1325	146	1	panel	panel	NOUN
dti-1325	146	2	b	b	NOUN
dti-1325	146	3	:	:	PUNCT
dti-1325	146	4	pac-1	pac-1	NOUN
dti-1325	146	5	-	-	PUNCT
dti-1325	146	6	fitc	fitc	NOUN
dti-1325	146	7	binds	bind	VERB
dti-1325	146	8	to	to	ADP
dti-1325	146	9	non	non	ADJ
dti-1325	146	10	-	-	ADJ
dti-1325	146	11	activated	activated	ADJ
dti-1325	146	12	αiib	αiib	ADJ
dti-1325	146	13	/	/	SYM
dti-1325	146	14	β3	β3	ADJ
dti-1325	146	15	complex	complex	NOUN
dti-1325	146	16	.	.	PUNCT
dti-1325	147	1	panel	panel	NOUN
dti-1325	147	2	c	c	NOUN
dti-1325	147	3	:	:	PUNCT
dti-1325	147	4	pac-1	pac-1	NOUN
dti-1325	147	5	-	-	NOUN
dti-1325	147	6	fitc	fitc	NOUN
dti-1325	147	7	bound	bind	VERB
dti-1325	147	8	to	to	ADP
dti-1325	147	9	2	2	NUM
dti-1325	147	10	mm	mm	NOUN
dti-1325	147	11	mn2	mn2	VERB
dti-1325	147	12	+	+	CCONJ
dti-1325	147	13	stimulated	stimulated	ADJ
dti-1325	147	14	αiib	αiib	ADJ
dti-1325	147	15	/	/	SYM
dti-1325	147	16	β3	β3	ADJ
dti-1325	147	17	complex	complex	NOUN
dti-1325	147	18	.	.	PUNCT
dti-1325	148	1	line	line	NOUN
dti-1325	148	2	1	1	NUM
dti-1325	148	3	,	,	PUNCT
dti-1325	148	4	mock	mock	ADJ
dti-1325	148	5	control	control	NOUN
dti-1325	148	6	(	(	PUNCT
dti-1325	148	7	cells	cell	NOUN
dti-1325	148	8	without	without	ADP
dti-1325	148	9	cdna	cdna	PROPN
dti-1325	148	10	insert	insert	PROPN
dti-1325	148	11	)	)	PUNCT
dti-1325	148	12	;	;	PUNCT
dti-1325	148	13	line	line	NOUN
dti-1325	148	14	2	2	NUM
dti-1325	148	15	,	,	PUNCT
dti-1325	148	16	cells	cell	NOUN
dti-1325	148	17	of	of	ADP
dti-1325	148	18	wild	wild	ADJ
dti-1325	148	19	type	type	NOUN
dti-1325	148	20	αiib	αiib	NOUN
dti-1325	148	21	with	with	ADP
dti-1325	148	22	β3	β3	ADJ
dti-1325	148	23	-	-	PUNCT
dti-1325	148	24	mut	mut	NOUN
dti-1325	148	25	cdnas	cdnas	PROPN
dti-1325	148	26	lane	lane	PROPN
dti-1325	148	27	3	3	NUM
dti-1325	148	28	,	,	PUNCT
dti-1325	148	29	cells	cell	NOUN
dti-1325	148	30	of	of	ADP
dti-1325	148	31	wild	wild	ADJ
dti-1325	148	32	type	type	NOUN
dti-1325	148	33	αiib	αiib	ADJ
dti-1325	148	34	cdna	cdna	PROPN
dti-1325	148	35	and	and	CCONJ
dti-1325	148	36	β3	β3	VERB
dti-1325	148	37	cdnas	cdna	NOUN
dti-1325	148	38	.	.	PUNCT
dti-1325	149	1	73	73	NUM
dti-1325	150	1	the	the	DET
dti-1325	150	2	beta3	beta3	X
dti-1325	150	3	499–513	499–513	NUM
dti-1325	150	4	peptide	peptide	NOUN
dti-1325	150	5	region	region	NOUN
dti-1325	150	6	is	be	AUX
dti-1325	150	7	required	require	VERB
dti-1325	150	8	for	for	ADP
dti-1325	150	9	alphaiib	alphaiib	ADJ
dti-1325	150	10	/	/	SYM
dti-1325	150	11	beta3	beta3	NOUN
dti-1325	150	12	active	active	ADJ
dti-1325	150	13	complex	complex	ADJ
dti-1325	150	14	drug	drug	NOUN
dti-1325	150	15	target	target	NOUN
dti-1325	150	16	insights	insight	NOUN
dti-1325	150	17	2008:3	2008:3	NUM
dti-1325	150	18	figure	figure	NOUN
dti-1325	150	19	4	4	NUM
dti-1325	150	20	.	.	PUNCT
dti-1325	150	21	effect	effect	NOUN
dti-1325	150	22	of	of	ADP
dti-1325	150	23	the	the	DET
dti-1325	150	24	defi	defi	NOUN
dti-1325	150	25	ned	ned	PROPN
dti-1325	150	26	β3	β3	PROPN
dti-1325	150	27	peptide	peptide	NOUN
dti-1325	150	28	(	(	PUNCT
dti-1325	150	29	p4	p4	ADJ
dti-1325	150	30	)	)	PUNCT
dti-1325	150	31	on	on	ADP
dti-1325	150	32	the	the	DET
dti-1325	150	33	binding	binding	NOUN
dti-1325	150	34	of	of	ADP
dti-1325	150	35	fitc	fitc	NOUN
dti-1325	150	36	-	-	PUNCT
dti-1325	150	37	pac-1	pac-1	NOUN
dti-1325	150	38	to	to	AUX
dti-1325	150	39	co	co	VERB
dti-1325	150	40	-	-	VERB
dti-1325	150	41	transfected	transfecte	VERB
dti-1325	150	42	cho	cho	NOUN
dti-1325	150	43	cells	cell	NOUN
dti-1325	150	44	.	.	PUNCT
dti-1325	151	1	the	the	DET
dti-1325	151	2	cho	cho	PROPN
dti-1325	151	3	cells	cell	NOUN
dti-1325	151	4	expressing	express	VERB
dti-1325	151	5	αiib	αiib	ADJ
dti-1325	151	6	/	/	SYM
dti-1325	151	7	β3	β3	ADJ
dti-1325	151	8	inactive	inactive	ADJ
dti-1325	151	9	complex	complex	NOUN
dti-1325	151	10	were	be	AUX
dti-1325	151	11	activated	activate	VERB
dti-1325	151	12	with	with	ADP
dti-1325	151	13	2	2	NUM
dti-1325	151	14	mm	mm	NOUN
dti-1325	151	15	mn2	mn2	VERB
dti-1325	151	16	+	+	X
dti-1325	151	17	in	in	ADP
dti-1325	151	18	the	the	DET
dti-1325	151	19	presence	presence	NOUN
dti-1325	151	20	of	of	ADP
dti-1325	151	21	various	various	ADJ
dti-1325	151	22	amounts	amount	NOUN
dti-1325	151	23	of	of	ADP
dti-1325	151	24	p4	p4	NOUN
dti-1325	151	25	for	for	ADP
dti-1325	151	26	45	45	NUM
dti-1325	151	27	minutes	minute	NOUN
dti-1325	151	28	at	at	ADP
dti-1325	151	29	room	room	NOUN
dti-1325	151	30	temperature	temperature	NOUN
dti-1325	151	31	.	.	PUNCT
dti-1325	152	1	following	follow	VERB
dti-1325	152	2	incubation	incubation	NOUN
dti-1325	152	3	,	,	PUNCT
dti-1325	152	4	an	an	DET
dti-1325	152	5	aliquot	aliquot	NOUN
dti-1325	152	6	of	of	ADP
dti-1325	152	7	pac-1	pac-1	NOUN
dti-1325	152	8	-	-	NOUN
dti-1325	152	9	fitc	fitc	NOUN
dti-1325	152	10	was	be	AUX
dti-1325	152	11	added	add	VERB
dti-1325	152	12	and	and	CCONJ
dti-1325	152	13	incubated	incubate	VERB
dti-1325	152	14	at	at	ADP
dti-1325	152	15	room	room	NOUN
dti-1325	152	16	temperature	temperature	NOUN
dti-1325	152	17	for	for	ADP
dti-1325	152	18	an	an	DET
dti-1325	152	19	additional	additional	ADJ
dti-1325	152	20	60	60	NUM
dti-1325	152	21	minutes	minute	NOUN
dti-1325	152	22	.	.	PUNCT
dti-1325	153	1	following	follow	VERB
dti-1325	153	2	three	three	NUM
dti-1325	153	3	washings	washing	NOUN
dti-1325	153	4	,	,	PUNCT
dti-1325	153	5	the	the	DET
dti-1325	153	6	fl	fl	PROPN
dti-1325	153	7	uorescent	uorescent	ADJ
dti-1325	153	8	stringency	stringency	NOUN
dti-1325	153	9	was	be	AUX
dti-1325	153	10	detected	detect	VERB
dti-1325	153	11	by	by	ADP
dti-1325	153	12	fl	fl	NUM
dti-1325	153	13	ow	ow	PROPN
dti-1325	153	14	cytometry	cytometry	PROPN
dti-1325	153	15	.	.	PUNCT
dti-1325	154	1	panel	panel	NOUN
dti-1325	154	2	a	a	DET
dti-1325	154	3	:	:	PUNCT
dti-1325	154	4	control	control	NOUN
dti-1325	154	5	,	,	PUNCT
dti-1325	154	6	(	(	PUNCT
dti-1325	154	7	cells	cell	NOUN
dti-1325	154	8	without	without	ADP
dti-1325	154	9	cdna	cdna	PROPN
dti-1325	154	10	insert	insert	PROPN
dti-1325	154	11	)	)	PUNCT
dti-1325	154	12	.	.	PUNCT
dti-1325	155	1	panel	panel	NOUN
dti-1325	155	2	b	b	X
dti-1325	155	3	:	:	PUNCT
dti-1325	155	4	cells	cell	NOUN
dti-1325	155	5	expressing	express	VERB
dti-1325	155	6	αiib	αiib	ADJ
dti-1325	155	7	/	/	SYM
dti-1325	155	8	β3	β3	NOUN
dti-1325	155	9	activated	activate	VERB
dti-1325	155	10	with	with	ADP
dti-1325	155	11	2	2	NUM
dti-1325	155	12	mm	mm	NOUN
dti-1325	155	13	mn2	mn2	VERB
dti-1325	155	14	+	+	PROPN
dti-1325	155	15	.	.	PUNCT
dti-1325	155	16	panel	panel	NOUN
dti-1325	155	17	c	c	NOUN
dti-1325	155	18	:	:	PUNCT
dti-1325	155	19	wild	wild	ADJ
dti-1325	155	20	type	type	NOUN
dti-1325	155	21	cells	cell	NOUN
dti-1325	155	22	activated	activate	VERB
dti-1325	155	23	with	with	ADP
dti-1325	155	24	2	2	NUM
dti-1325	155	25	mm	mm	NOUN
dti-1325	155	26	mn2	mn2	VERB
dti-1325	155	27	+	+	NUM
dti-1325	155	28	and	and	CCONJ
dti-1325	155	29	60	60	NUM
dti-1325	155	30	µm	µm	NOUN
dti-1325	155	31	of	of	ADP
dti-1325	155	32	peptide	peptide	NOUN
dti-1325	155	33	.	.	PUNCT
dti-1325	156	1	panel	panel	NOUN
dti-1325	156	2	d	d	NOUN
dti-1325	156	3	:	:	PUNCT
dti-1325	156	4	cells	cell	NOUN
dti-1325	156	5	activated	activate	VERB
dti-1325	156	6	with	with	ADP
dti-1325	156	7	2	2	NUM
dti-1325	156	8	mm	mm	NOUN
dti-1325	156	9	mn2	mn2	VERB
dti-1325	156	10	+	+	NUM
dti-1325	156	11	and	and	CCONJ
dti-1325	156	12	80	80	NUM
dti-1325	156	13	µm	µm	NOUN
dti-1325	156	14	of	of	ADP
dti-1325	156	15	peptide	peptide	NOUN
dti-1325	156	16	.	.	PUNCT
dti-1325	157	1	figure	figure	NOUN
dti-1325	157	2	5	5	NUM
dti-1325	157	3	.	.	PUNCT
dti-1325	158	1	binding	bind	VERB
dti-1325	158	2	of	of	ADP
dti-1325	158	3	[	[	X
dti-1325	158	4	3h]-fi	3h]-fi	NUM
dti-1325	158	5	brinogen	brinogen	NOUN
dti-1325	158	6	on	on	ADP
dti-1325	158	7	cho	cho	NOUN
dti-1325	158	8	cells	cell	NOUN
dti-1325	158	9	expressing	express	VERB
dti-1325	158	10	the	the	DET
dti-1325	158	11	αiib	αiib	ADJ
dti-1325	158	12	/	/	SYM
dti-1325	158	13	β3	β3	ADJ
dti-1325	158	14	complex	complex	NOUN
dti-1325	158	15	and	and	CCONJ
dti-1325	158	16	the	the	DET
dti-1325	158	17	effect	effect	NOUN
dti-1325	158	18	of	of	ADP
dti-1325	158	19	the	the	DET
dti-1325	158	20	p4	p4	ADJ
dti-1325	158	21	peptide	peptide	NOUN
dti-1325	158	22	(	(	PUNCT
dti-1325	158	23	open	open	ADJ
dti-1325	158	24	-	-	PUNCT
dti-1325	158	25	circle	circle	NOUN
dti-1325	158	26	line	line	NOUN
dti-1325	158	27	)	)	PUNCT
dti-1325	158	28	and	and	CCONJ
dti-1325	158	29	the	the	DET
dti-1325	158	30	p4s	p4s	PROPN
dti-1325	158	31	(	(	PUNCT
dti-1325	158	32	square	square	ADJ
dti-1325	158	33	-	-	PUNCT
dti-1325	158	34	fi	fi	NOUN
dti-1325	158	35	lled	lle	VERB
dti-1325	158	36	line	line	NOUN
dti-1325	158	37	)	)	PUNCT
dti-1325	158	38	from	from	ADP
dti-1325	158	39	β3	β3	PROPN
dti-1325	158	40	.	.	PUNCT
dti-1325	159	1	the	the	DET
dti-1325	159	2	cells	cell	NOUN
dti-1325	159	3	were	be	AUX
dti-1325	159	4	incubated	incubate	VERB
dti-1325	159	5	with	with	ADP
dti-1325	159	6	2	2	NUM
dti-1325	159	7	mm	mm	NOUN
dti-1325	159	8	mn2	mn2	VERB
dti-1325	159	9	+	+	CCONJ
dti-1325	159	10	and	and	CCONJ
dti-1325	159	11	different	different	ADJ
dti-1325	159	12	amounts	amount	NOUN
dti-1325	159	13	of	of	ADP
dti-1325	159	14	peptide	peptide	NOUN
dti-1325	159	15	(	(	PUNCT
dti-1325	159	16	0–80	0–80	NOUN
dti-1325	159	17	µm	µm	NOUN
dti-1325	159	18	)	)	PUNCT
dti-1325	159	19	.	.	PUNCT
dti-1325	160	1	the	the	DET
dti-1325	160	2	y	y	NOUN
dti-1325	160	3	-	-	PUNCT
dti-1325	160	4	axis	axis	NOUN
dti-1325	160	5	indicates	indicate	VERB
dti-1325	160	6	the	the	DET
dti-1325	160	7	percentage	percentage	NOUN
dti-1325	160	8	of	of	ADP
dti-1325	160	9	[	[	X
dti-1325	160	10	3h]-fi	3h]-fi	NUM
dti-1325	160	11	brinogen	brinogen	NOUN
dti-1325	160	12	binding	bind	VERB
dti-1325	160	13	.	.	PUNCT
dti-1325	161	1	the	the	DET
dti-1325	161	2	peptide	peptide	NOUN
dti-1325	161	3	concentrations	concentration	NOUN
dti-1325	161	4	were	be	AUX
dti-1325	161	5	10	10	NUM
dti-1325	161	6	µm	µm	NOUN
dti-1325	161	7	,	,	PUNCT
dti-1325	161	8	20	20	NUM
dti-1325	161	9	µm	µm	NOUN
dti-1325	161	10	,	,	PUNCT
dti-1325	161	11	40	40	NUM
dti-1325	161	12	µm	µm	NOUN
dti-1325	161	13	and	and	CCONJ
dti-1325	161	14	80	80	NUM
dti-1325	161	15	µm	µm	NOUN
dti-1325	161	16	for	for	ADP
dti-1325	161	17	various	various	ADJ
dti-1325	161	18	time	time	NOUN
dti-1325	161	19	points	point	NOUN
dti-1325	161	20	beginning	begin	VERB
dti-1325	161	21	with	with	ADP
dti-1325	161	22	time	time	NOUN
dti-1325	161	23	0	0	NUM
dti-1325	161	24	,	,	PUNCT
dti-1325	161	25	respectively	respectively	ADV
dti-1325	161	26	(	(	PUNCT
dti-1325	161	27	p4	p4	ADJ
dti-1325	161	28	,	,	PUNCT
dti-1325	161	29	line	line	NOUN
dti-1325	161	30	with	with	ADP
dti-1325	161	31	open	open	ADJ
dti-1325	161	32	circles	circle	NOUN
dti-1325	161	33	;	;	PUNCT
dti-1325	161	34	p4s	p4s	PROPN
dti-1325	161	35	,	,	PUNCT
dti-1325	161	36	line	line	NOUN
dti-1325	161	37	with	with	ADP
dti-1325	161	38	fi	fi	NOUN
dti-1325	161	39	lled	lle	VERB
dti-1325	161	40	squares	square	NOUN
dti-1325	161	41	)	)	PUNCT
dti-1325	161	42	.	.	PUNCT
dti-1325	162	1	the	the	DET
dti-1325	162	2	data	datum	NOUN
dti-1325	162	3	expressed	express	VERB
dti-1325	162	4	is	be	AUX
dti-1325	162	5	an	an	DET
dti-1325	162	6	average	average	NOUN
dti-1325	162	7	of	of	ADP
dti-1325	162	8	duplicates	duplicate	NOUN
dti-1325	162	9	per	per	ADP
dti-1325	162	10	experiment	experiment	NOUN
dti-1325	162	11	and	and	CCONJ
dti-1325	162	12	repeated	repeat	VERB
dti-1325	162	13	three	three	NUM
dti-1325	162	14	times	time	NOUN
dti-1325	162	15	with	with	ADP
dti-1325	162	16	similar	similar	ADJ
dti-1325	162	17	results	result	NOUN
dti-1325	162	18	.	.	PUNCT
dti-1325	163	1	a	a	DET
dti-1325	163	2	representative	representative	ADJ
dti-1325	163	3	study	study	NOUN
dti-1325	163	4	is	be	AUX
dti-1325	163	5	shown	show	VERB
dti-1325	163	6	.	.	PUNCT
dti-1325	164	1	0	0	NUM
dti-1325	165	1	20	20	NUM
dti-1325	165	2	40	40	NUM
dti-1325	165	3	60	60	NUM
dti-1325	165	4	80	80	NUM
dti-1325	165	5	100	100	NUM
dti-1325	165	6	120	120	NUM
dti-1325	165	7	0	0	NUM
dti-1325	165	8	10	10	NUM
dti-1325	165	9	20	20	NUM
dti-1325	165	10	40	40	NUM
dti-1325	165	11	80	80	NUM
dti-1325	165	12	peptide	peptide	NOUN
dti-1325	165	13	concentration	concentration	NOUN
dti-1325	165	14	(	(	PUNCT
dti-1325	165	15	µm	µm	NOUN
dti-1325	165	16	)	)	PUNCT
dti-1325	165	17	f	f	PROPN
dti-1325	166	1	ib	ib	PROPN
dti-1325	166	2	rin	rin	PROPN
dti-1325	166	3	og	og	PROPN
dti-1325	166	4	en	en	PROPN
dti-1325	166	5	b	b	PROPN
dti-1325	166	6	in	in	ADP
dti-1325	166	7	di	di	X
dti-1325	166	8	ng	ng	PROPN
dti-1325	166	9	(	(	PUNCT
dti-1325	166	10	%	%	NOUN
dti-1325	166	11	)	)	PUNCT
dti-1325	166	12	discussion	discussion	NOUN
dti-1325	166	13	we	we	PRON
dti-1325	166	14	have	have	AUX
dti-1325	166	15	previously	previously	ADV
dti-1325	166	16	defi	defi	VERB
dti-1325	166	17	ned	ned	NOUN
dti-1325	166	18	a	a	DET
dti-1325	166	19	peptide	peptide	NOUN
dti-1325	166	20	(	(	PUNCT
dti-1325	166	21	p4	p4	ADJ
dti-1325	166	22	)	)	PUNCT
dti-1325	166	23	,	,	PUNCT
dti-1325	166	24	amino	amino	NOUN
dti-1325	166	25	acid	acid	NOUN
dti-1325	166	26	residues	residue	NOUN
dti-1325	166	27	from	from	ADP
dti-1325	166	28	499–513	499–513	NUM
dti-1325	166	29	of	of	ADP
dti-1325	166	30	β3	β3	ADJ
dti-1325	166	31	as	as	ADP
dti-1325	166	32	one	one	NUM
dti-1325	166	33	of	of	ADP
dti-1325	166	34	several	several	ADJ
dti-1325	166	35	important	important	ADJ
dti-1325	166	36	sites	site	NOUN
dti-1325	166	37	of	of	ADP
dti-1325	166	38	the	the	DET
dti-1325	166	39	active	active	ADJ
dti-1325	166	40	conformational	conformational	ADJ
dti-1325	166	41	state	state	NOUN
dti-1325	166	42	of	of	ADP
dti-1325	166	43	the	the	DET
dti-1325	166	44	complex	complex	ADJ
dti-1325	166	45	αiib	αiib	NOUN
dti-1325	166	46	/	/	SYM
dti-1325	166	47	ß3	ß3	PROPN
dti-1325	166	48	(	(	PUNCT
dti-1325	166	49	chiang	chiang	PROPN
dti-1325	166	50	and	and	CCONJ
dti-1325	166	51	zhu	zhu	PROPN
dti-1325	166	52	,	,	PUNCT
dti-1325	166	53	2005	2005	NUM
dti-1325	166	54	)	)	PUNCT
dti-1325	166	55	.	.	PUNCT
dti-1325	167	1	in	in	ADP
dti-1325	167	2	this	this	DET
dti-1325	167	3	investigation	investigation	NOUN
dti-1325	167	4	,	,	PUNCT
dti-1325	167	5	we	we	PRON
dti-1325	167	6	have	have	AUX
dti-1325	167	7	performed	perform	VERB
dti-1325	167	8	experiments	experiment	NOUN
dti-1325	167	9	to	to	PART
dti-1325	167	10	study	study	VERB
dti-1325	167	11	its	its	PRON
dti-1325	167	12	function	function	NOUN
dti-1325	167	13	on	on	ADP
dti-1325	167	14	the	the	DET
dti-1325	167	15	formation	formation	NOUN
dti-1325	167	16	of	of	ADP
dti-1325	167	17	the	the	DET
dti-1325	167	18	αiib	αiib	ADJ
dti-1325	167	19	/	/	SYM
dti-1325	167	20	β3	β3	ADJ
dti-1325	167	21	active	active	ADJ
dti-1325	167	22	complex	complex	NOUN
dti-1325	167	23	.	.	PUNCT
dti-1325	168	1	we	we	PRON
dti-1325	168	2	have	have	AUX
dti-1325	168	3	established	establish	VERB
dti-1325	168	4	a	a	DET
dti-1325	168	5	stable	stable	ADJ
dti-1325	168	6	cell	cell	NOUN
dti-1325	168	7	line	line	NOUN
dti-1325	168	8	that	that	PRON
dti-1325	168	9	was	be	AUX
dti-1325	168	10	co	co	VERB
dti-1325	168	11	-	-	VERB
dti-1325	168	12	transfected	transfecte	VERB
dti-1325	168	13	with	with	ADP
dti-1325	168	14	wild	wild	ADJ
dti-1325	168	15	type	type	NOUN
dti-1325	168	16	αiib	αiib	ADJ
dti-1325	168	17	and	and	CCONJ
dti-1325	168	18	wild	wild	ADJ
dti-1325	168	19	type	type	NOUN
dti-1325	168	20	β3	β3	PROPN
dti-1325	168	21	cdnas	cdna	NOUN
dti-1325	168	22	in	in	ADP
dti-1325	168	23	cho	cho	NOUN
dti-1325	168	24	cells	cell	NOUN
dti-1325	168	25	.	.	PUNCT
dti-1325	169	1	results	result	NOUN
dti-1325	169	2	revealed	reveal	VERB
dti-1325	169	3	that	that	SCONJ
dti-1325	169	4	the	the	DET
dti-1325	169	5	p4	p4	ADJ
dti-1325	169	6	peptide	peptide	NOUN
dti-1325	169	7	inhibited	inhibit	VERB
dti-1325	169	8	both	both	DET
dti-1325	169	9	fitc	fitc	NOUN
dti-1325	169	10	-	-	PUNCT
dti-1325	169	11	pac-1	pac-1	NOUN
dti-1325	169	12	and	and	CCONJ
dti-1325	169	13	[	[	X
dti-1325	169	14	3h]-fi	3h]-fi	NUM
dti-1325	169	15	brinogen	brinogen	NOUN
dti-1325	169	16	binding	bind	VERB
dti-1325	169	17	to	to	ADP
dti-1325	169	18	the	the	DET
dti-1325	169	19	74	74	NUM
dti-1325	169	20	woo	woo	NOUN
dti-1325	169	21	-	-	PUNCT
dti-1325	169	22	rasberry	rasberry	NOUN
dti-1325	169	23	and	and	CCONJ
dti-1325	169	24	chiang	chiang	PROPN
dti-1325	169	25	drug	drug	PROPN
dti-1325	169	26	target	target	NOUN
dti-1325	169	27	insights	insight	NOUN
dti-1325	169	28	2008:3	2008:3	NUM
dti-1325	169	29	cell	cell	NOUN
dti-1325	169	30	surface	surface	NOUN
dti-1325	169	31	expressed	express	VERB
dti-1325	169	32	mn2	mn2	VERB
dti-1325	169	33	+	+	ADJ
dti-1325	169	34	-activated	-activated	ADJ
dti-1325	169	35	αiib	αiib	ADJ
dti-1325	169	36	/	/	SYM
dti-1325	169	37	β3	β3	NOUN
dti-1325	169	38	complex	complex	NOUN
dti-1325	169	39	.	.	PUNCT
dti-1325	170	1	in	in	ADP
dti-1325	170	2	addition	addition	NOUN
dti-1325	170	3	,	,	PUNCT
dti-1325	170	4	three	three	NUM
dti-1325	170	5	stable	stable	ADJ
dti-1325	170	6	cell	cell	NOUN
dti-1325	170	7	lines	line	NOUN
dti-1325	170	8	of	of	ADP
dti-1325	170	9	cotransfected	cotransfecte	VERB
dti-1325	170	10	wild	wild	ADJ
dti-1325	170	11	type	type	NOUN
dti-1325	170	12	αiib	αiib	ADJ
dti-1325	170	13	and	and	CCONJ
dti-1325	170	14	β3	β3	ADJ
dti-1325	170	15	-	-	PUNCT
dti-1325	170	16	mut	mut	NOUN
dti-1325	170	17	cdnas	cdna	NOUN
dti-1325	170	18	also	also	ADV
dti-1325	170	19	demonstrated	demonstrate	VERB
dti-1325	170	20	a	a	DET
dti-1325	170	21	decrease	decrease	NOUN
dti-1325	170	22	in	in	ADP
dti-1325	170	23	fitc	fitc	NOUN
dti-1325	170	24	-	-	PUNCT
dti-1325	170	25	pac-1	pac-1	NOUN
dti-1325	170	26	binding	bind	VERB
dti-1325	170	27	and	and	CCONJ
dti-1325	170	28	[	[	X
dti-1325	170	29	3h]-fi	3h]-fi	NUM
dti-1325	170	30	brinogen	brinogen	NOUN
dti-1325	170	31	binding	bind	VERB
dti-1325	170	32	.	.	PUNCT
dti-1325	171	1	these	these	DET
dti-1325	171	2	results	result	NOUN
dti-1325	171	3	are	be	AUX
dti-1325	171	4	consistence	consistence	NOUN
dti-1325	171	5	with	with	ADP
dti-1325	171	6	our	our	PRON
dti-1325	171	7	earlier	early	ADJ
dti-1325	171	8	report	report	NOUN
dti-1325	171	9	that	that	SCONJ
dti-1325	171	10	the	the	DET
dti-1325	171	11	p4	p4	ADJ
dti-1325	171	12	peptide	peptide	NOUN
dti-1325	171	13	inhibits	inhibit	VERB
dti-1325	171	14	binding	bind	VERB
dti-1325	171	15	of	of	ADP
dti-1325	171	16	fitc	fitc	NOUN
dti-1325	171	17	-	-	PUNCT
dti-1325	171	18	pac-1	pac-1	NOUN
dti-1325	171	19	on	on	ADP
dti-1325	171	20	human	human	ADJ
dti-1325	171	21	platelets	platelet	NOUN
dti-1325	171	22	(	(	PUNCT
dti-1325	171	23	chiang	chiang	PROPN
dti-1325	171	24	and	and	CCONJ
dti-1325	171	25	zhu	zhu	PROPN
dti-1325	171	26	,	,	PUNCT
dti-1325	171	27	2005	2005	NUM
dti-1325	171	28	)	)	PUNCT
dti-1325	171	29	.	.	PUNCT
dti-1325	172	1	collagen	collagen	NOUN
dti-1325	172	2	-	-	PUNCT
dti-1325	172	3	induced	induce	VERB
dti-1325	172	4	platelet	platelet	NOUN
dti-1325	172	5	aggregation	aggregation	NOUN
dti-1325	172	6	is	be	AUX
dti-1325	172	7	mediated	mediate	VERB
dti-1325	172	8	by	by	ADP
dti-1325	172	9	the	the	DET
dti-1325	172	10	released	release	VERB
dti-1325	172	11	of	of	ADP
dti-1325	172	12	adp	adp	PROPN
dti-1325	172	13	from	from	ADP
dti-1325	172	14	the	the	DET
dti-1325	172	15	collagen	collagen	NOUN
dti-1325	172	16	-	-	PUNCT
dti-1325	172	17	activated	activate	VERB
dti-1325	172	18	platelets	platelet	NOUN
dti-1325	172	19	.	.	PUNCT
dti-1325	173	1	in	in	ADP
dti-1325	173	2	the	the	DET
dti-1325	173	3	present	present	ADJ
dti-1325	173	4	studies	study	NOUN
dti-1325	173	5	,	,	PUNCT
dti-1325	173	6	we	we	PRON
dti-1325	173	7	have	have	AUX
dti-1325	173	8	used	use	VERB
dti-1325	173	9	suboptimal	suboptimal	ADJ
dti-1325	173	10	concentrations	concentration	NOUN
dti-1325	173	11	of	of	ADP
dti-1325	173	12	adp	adp	PROPN
dti-1325	173	13	to	to	PART
dti-1325	173	14	trigger	trigger	VERB
dti-1325	173	15	partial	partial	ADJ
dti-1325	173	16	platelet	platelet	NOUN
dti-1325	173	17	activation	activation	NOUN
dti-1325	173	18	for	for	ADP
dti-1325	173	19	the	the	DET
dti-1325	173	20	binding	binding	NOUN
dti-1325	173	21	of	of	ADP
dti-1325	173	22	[	[	X
dti-1325	173	23	3h]-fi	3h]-fi	NUM
dti-1325	173	24	brinogen	brinogen	NOUN
dti-1325	173	25	.	.	PUNCT
dti-1325	174	1	however	however	ADV
dti-1325	174	2	,	,	PUNCT
dti-1325	174	3	under	under	ADP
dti-1325	174	4	these	these	DET
dti-1325	174	5	same	same	ADJ
dti-1325	174	6	conditions	condition	NOUN
dti-1325	174	7	,	,	PUNCT
dti-1325	174	8	the	the	DET
dti-1325	174	9	addition	addition	NOUN
dti-1325	174	10	of	of	ADP
dti-1325	174	11	p4s	p4s	PROPN
dti-1325	174	12	does	do	AUX
dti-1325	174	13	not	not	PART
dti-1325	174	14	inhibit	inhibit	VERB
dti-1325	174	15	the	the	DET
dti-1325	174	16	binding	binding	NOUN
dti-1325	174	17	of	of	ADP
dti-1325	174	18	[	[	X
dti-1325	174	19	3h]-fi	3h]-fi	NUM
dti-1325	174	20	brinogen	brinogen	NOUN
dti-1325	174	21	.	.	PUNCT
dti-1325	175	1	in	in	ADP
dti-1325	175	2	contrast	contrast	NOUN
dti-1325	175	3	,	,	PUNCT
dti-1325	175	4	the	the	DET
dti-1325	175	5	addition	addition	NOUN
dti-1325	175	6	of	of	ADP
dti-1325	175	7	p4	p4	ADJ
dti-1325	175	8	after	after	SCONJ
dti-1325	175	9	platelets	platelet	NOUN
dti-1325	175	10	become	become	VERB
dti-1325	175	11	fully	fully	ADV
dti-1325	175	12	activated	activate	VERB
dti-1325	175	13	,	,	PUNCT
dti-1325	175	14	does	do	AUX
dti-1325	175	15	not	not	PART
dti-1325	175	16	inhibit	inhibit	VERB
dti-1325	175	17	fi	fi	NOUN
dti-1325	175	18	brinogen	brinogen	NOUN
dti-1325	175	19	binding	binding	NOUN
dti-1325	175	20	.	.	PUNCT
dti-1325	176	1	the	the	DET
dti-1325	176	2	2,3,5,6	2,3,5,6	NUM
dti-1325	176	3	-	-	PUNCT
dti-1325	176	4	tetrafl	tetrafl	NOUN
dti-1325	176	5	uorophenyl	uorophenyl	NOUN
dti-1325	176	6	ester	ester	NOUN
dti-1325	176	7	(	(	PUNCT
dti-1325	176	8	purchased	purchase	VERB
dti-1325	176	9	from	from	ADP
dti-1325	176	10	molecular	molecular	ADJ
dti-1325	176	11	probes)-labeled	probes)-labele	VERB
dti-1325	176	12	p4	p4	NOUN
dti-1325	176	13	and	and	CCONJ
dti-1325	176	14	p4s	p4s	PROPN
dti-1325	176	15	could	could	AUX
dti-1325	176	16	not	not	PART
dti-1325	176	17	bind	bind	VERB
dti-1325	176	18	on	on	ADP
dti-1325	176	19	the	the	DET
dti-1325	176	20	fi	fi	NOUN
dti-1325	176	21	brinogen	brinogen	NOUN
dti-1325	176	22	-	-	PUNCT
dti-1325	176	23	coated	coat	VERB
dti-1325	176	24	wells	well	NOUN
dti-1325	176	25	.	.	PUNCT
dti-1325	177	1	these	these	DET
dti-1325	177	2	fi	fi	NOUN
dti-1325	177	3	ndings	nding	NOUN
dti-1325	177	4	suggest	suggest	VERB
dti-1325	177	5	that	that	SCONJ
dti-1325	177	6	the	the	DET
dti-1325	177	7	peptide	peptide	NOUN
dti-1325	177	8	does	do	AUX
dti-1325	177	9	not	not	PART
dti-1325	177	10	bind	bind	VERB
dti-1325	177	11	to	to	ADP
dti-1325	177	12	fi	fi	NOUN
dti-1325	177	13	brinogen	brinogen	PROPN
dti-1325	177	14	per	per	X
dti-1325	177	15	se	se	X
dti-1325	177	16	to	to	PART
dti-1325	177	17	lower	lower	VERB
dti-1325	177	18	[	[	X
dti-1325	177	19	3h]-fi	3h]-fi	NUM
dti-1325	177	20	brinogen	brinogen	NOUN
dti-1325	177	21	concentration	concentration	NOUN
dti-1325	177	22	in	in	ADP
dti-1325	177	23	turn	turn	NOUN
dti-1325	177	24	to	to	PART
dti-1325	177	25	decrease	decrease	VERB
dti-1325	177	26	the	the	DET
dti-1325	177	27	binding	binding	NOUN
dti-1325	177	28	.	.	PUNCT
dti-1325	178	1	parise	parise	PROPN
dti-1325	178	2	et	et	PROPN
dti-1325	178	3	al	al	PROPN
dti-1325	178	4	.	.	PROPN
dti-1325	178	5	(	(	PUNCT
dti-1325	178	6	1987	1987	NUM
dti-1325	178	7	)	)	PUNCT
dti-1325	178	8	and	and	CCONJ
dti-1325	178	9	du	du	PROPN
dti-1325	178	10	et	et	PROPN
dti-1325	178	11	al	al	PROPN
dti-1325	178	12	.	.	PROPN
dti-1325	178	13	(	(	PUNCT
dti-1325	178	14	1991	1991	NUM
dti-1325	178	15	)	)	PUNCT
dti-1325	178	16	have	have	AUX
dti-1325	178	17	reported	report	VERB
dti-1325	178	18	that	that	SCONJ
dti-1325	178	19	the	the	DET
dti-1325	178	20	rgd	rgd	PROPN
dti-1325	178	21	peptide	peptide	NOUN
dti-1325	178	22	(	(	PUNCT
dti-1325	178	23	a	a	DET
dti-1325	178	24	recognition	recognition	NOUN
dti-1325	178	25	sequence	sequence	NOUN
dti-1325	178	26	for	for	ADP
dti-1325	178	27	fibrinogen	fibrinogen	NOUN
dti-1325	178	28	binding	binding	NOUN
dti-1325	178	29	)	)	PUNCT
dti-1325	178	30	or	or	CCONJ
dti-1325	178	31	rgdderived	rgdderive	VERB
dti-1325	178	32	peptides	peptide	NOUN
dti-1325	178	33	inhibit(s	inhibit(s	PROPN
dti-1325	178	34	)	)	PUNCT
dti-1325	178	35	the	the	DET
dti-1325	178	36	binding	bind	VERB
dti-1325	178	37	site	site	NOUN
dti-1325	178	38	exposed	expose	VERB
dti-1325	178	39	by	by	ADP
dti-1325	178	40	conformational	conformational	ADJ
dti-1325	178	41	changes	change	NOUN
dti-1325	178	42	in	in	ADP
dti-1325	178	43	platelets	platelet	NOUN
dti-1325	178	44	.	.	PUNCT
dti-1325	179	1	our	our	PRON
dti-1325	179	2	results	result	NOUN
dti-1325	179	3	showed	show	VERB
dti-1325	179	4	that	that	SCONJ
dti-1325	179	5	p4	p4	ADJ
dti-1325	179	6	peptide	peptide	NOUN
dti-1325	179	7	inhibits	inhibit	VERB
dti-1325	179	8	the	the	DET
dti-1325	179	9	binding	binding	NOUN
dti-1325	179	10	of	of	ADP
dti-1325	179	11	both	both	DET
dti-1325	179	12	fitc	fitc	NOUN
dti-1325	179	13	-	-	PUNCT
dti-1325	179	14	pac-1	pac-1	NOUN
dti-1325	179	15	and	and	CCONJ
dti-1325	179	16	[	[	X
dti-1325	179	17	3h]-fi	3h]-fi	NUM
dti-1325	179	18	brinogen	brinogen	NOUN
dti-1325	179	19	on	on	ADP
dti-1325	179	20	the	the	DET
dti-1325	179	21	stably	stably	ADV
dti-1325	179	22	co	co	ADJ
dti-1325	179	23	-	-	VERB
dti-1325	179	24	transfected	transfecte	VERB
dti-1325	179	25	mn2	mn2	VERB
dti-1325	179	26	+	+	VERB
dti-1325	179	27	-activated	-activated	ADJ
dti-1325	179	28	αiib	αiib	ADJ
dti-1325	179	29	/	/	SYM
dti-1325	179	30	β3	β3	NOUN
dti-1325	179	31	complex	complex	NOUN
dti-1325	179	32	.	.	PUNCT
dti-1325	180	1	the	the	DET
dti-1325	180	2	dose	dose	NOUN
dti-1325	180	3	-	-	PUNCT
dti-1325	180	4	dependent	dependent	ADJ
dti-1325	180	5	inhibitory	inhibitory	ADJ
dti-1325	180	6	effect	effect	NOUN
dti-1325	180	7	of	of	ADP
dti-1325	180	8	p4	p4	ADJ
dti-1325	180	9	peptide	peptide	NOUN
dti-1325	180	10	indirectly	indirectly	ADV
dti-1325	180	11	leads	lead	VERB
dti-1325	180	12	us	we	PRON
dti-1325	180	13	to	to	PART
dti-1325	180	14	postulate	postulate	VERB
dti-1325	180	15	that	that	SCONJ
dti-1325	180	16	the	the	DET
dti-1325	180	17	peptide	peptide	NOUN
dti-1325	180	18	binds	bind	VERB
dti-1325	180	19	to	to	PART
dti-1325	180	20	αiib	αiib	VERB
dti-1325	180	21	and	and	CCONJ
dti-1325	180	22	prevents	prevent	VERB
dti-1325	180	23	the	the	DET
dti-1325	180	24	formation	formation	NOUN
dti-1325	180	25	of	of	ADP
dti-1325	180	26	the	the	DET
dti-1325	180	27	active	active	ADJ
dti-1325	180	28	αiib	αiib	ADJ
dti-1325	180	29	/	/	SYM
dti-1325	180	30	β3	β3	NOUN
dti-1325	180	31	complex	complex	NOUN
dti-1325	180	32	.	.	PUNCT
dti-1325	181	1	alternatively	alternatively	ADV
dti-1325	181	2	,	,	PUNCT
dti-1325	181	3	p4	p4	ADJ
dti-1325	181	4	modifi	modifi	NOUN
dti-1325	181	5	es	es	ADP
dti-1325	181	6	the	the	DET
dti-1325	181	7	αiib	αiib	ADJ
dti-1325	181	8	/	/	SYM
dti-1325	181	9	β3	β3	ADJ
dti-1325	181	10	complex	complex	ADJ
dti-1325	181	11	conformation	conformation	NOUN
dti-1325	181	12	in	in	ADP
dti-1325	181	13	some	some	DET
dti-1325	181	14	fashion	fashion	NOUN
dti-1325	181	15	to	to	PART
dti-1325	181	16	keep	keep	VERB
dti-1325	181	17	it	it	PRON
dti-1325	181	18	in	in	ADP
dti-1325	181	19	the	the	DET
dti-1325	181	20	inactive	inactive	ADJ
dti-1325	181	21	state	state	NOUN
dti-1325	181	22	.	.	PUNCT
dti-1325	182	1	in	in	ADP
dti-1325	182	2	our	our	PRON
dti-1325	182	3	results	result	NOUN
dti-1325	182	4	,	,	PUNCT
dti-1325	182	5	the	the	DET
dti-1325	182	6	peptide	peptide	ADJ
dti-1325	182	7	inhibitory	inhibitory	ADJ
dti-1325	182	8	effects	effect	NOUN
dti-1325	182	9	are	be	AUX
dti-1325	182	10	partial	partial	ADJ
dti-1325	182	11	.	.	PUNCT
dti-1325	183	1	a	a	DET
dti-1325	183	2	plausible	plausible	ADJ
dti-1325	183	3	explanation	explanation	NOUN
dti-1325	183	4	would	would	AUX
dti-1325	183	5	be	be	AUX
dti-1325	183	6	that	that	SCONJ
dti-1325	183	7	there	there	PRON
dti-1325	183	8	is	be	VERB
dti-1325	183	9	more	more	ADJ
dti-1325	183	10	than	than	ADP
dti-1325	183	11	one	one	NUM
dti-1325	183	12	region	region	NOUN
dti-1325	183	13	involved	involve	VERB
dti-1325	183	14	in	in	ADP
dti-1325	183	15	the	the	DET
dti-1325	183	16	activation	activation	NOUN
dti-1325	183	17	of	of	ADP
dti-1325	183	18	the	the	DET
dti-1325	183	19	complex	complex	ADJ
dti-1325	183	20	formation	formation	NOUN
dti-1325	183	21	.	.	PUNCT
dti-1325	184	1	our	our	PRON
dti-1325	184	2	results	result	NOUN
dti-1325	184	3	would	would	AUX
dti-1325	184	4	support	support	VERB
dti-1325	184	5	takagi	takagi	NOUN
dti-1325	184	6	’s	’s	PART
dti-1325	184	7	fi	fi	NOUN
dti-1325	184	8	nding	nding	NOUN
dti-1325	184	9	,	,	PUNCT
dti-1325	184	10	in	in	ADP
dti-1325	184	11	which	which	PRON
dti-1325	184	12	he	he	PRON
dti-1325	184	13	suggests	suggest	VERB
dti-1325	184	14	a	a	DET
dti-1325	184	15	“	"	PUNCT
dti-1325	184	16	2	2	NUM
dti-1325	184	17	-	-	PUNCT
dti-1325	184	18	site	site	NOUN
dti-1325	184	19	docking	docking	NOUN
dti-1325	184	20	model	model	NOUN
dti-1325	184	21	”	"	PUNCT
dti-1325	184	22	from	from	ADP
dti-1325	184	23	his	his	PRON
dti-1325	184	24	study	study	NOUN
dti-1325	184	25	of	of	ADP
dti-1325	184	26	ligand	ligand	ADJ
dti-1325	184	27	recognition	recognition	NOUN
dti-1325	184	28	by	by	ADP
dti-1325	184	29	rgddependent	rgddependent	PROPN
dti-1325	184	30	integrins	integrin	NOUN
dti-1325	184	31	(	(	PUNCT
dti-1325	184	32	takagi	takagi	NOUN
dti-1325	184	33	,	,	PUNCT
dti-1325	184	34	2004	2004	NUM
dti-1325	184	35	)	)	PUNCT
dti-1325	184	36	.	.	PUNCT
dti-1325	185	1	blystone	blystone	NOUN
dti-1325	185	2	et	et	PROPN
dti-1325	185	3	al	al	PROPN
dti-1325	185	4	.	.	PROPN
dti-1325	185	5	(	(	PUNCT
dti-1325	185	6	1995	1995	NUM
dti-1325	185	7	)	)	PUNCT
dti-1325	185	8	has	have	AUX
dti-1325	185	9	reported	report	VERB
dti-1325	185	10	that	that	DET
dti-1325	185	11	exposure	exposure	NOUN
dti-1325	185	12	to	to	AUX
dti-1325	185	13	mn2	mn2	VERB
dti-1325	185	14	+	+	CCONJ
dti-1325	185	15	shifts	shift	NOUN
dti-1325	185	16	the	the	DET
dti-1325	185	17	β3	β3	ADJ
dti-1325	185	18	integrin	integrin	NOUN
dti-1325	185	19	to	to	ADP
dti-1325	185	20	their	their	PRON
dti-1325	185	21	high	high	ADJ
dti-1325	185	22	affi	affi	PROPN
dti-1325	185	23	nity	nity	NOUN
dti-1325	185	24	state	state	NOUN
dti-1325	185	25	and	and	CCONJ
dti-1325	185	26	possibly	possibly	ADV
dti-1325	185	27	activation	activation	NOUN
dti-1325	185	28	of	of	ADP
dti-1325	185	29	the	the	DET
dti-1325	185	30	receptor	receptor	NOUN
dti-1325	185	31	or	or	CCONJ
dti-1325	185	32	the	the	DET
dti-1325	185	33	subsequent	subsequent	ADJ
dti-1325	185	34	function	function	NOUN
dti-1325	185	35	of	of	ADP
dti-1325	185	36	β3	β3	ADJ
dti-1325	185	37	following	follow	VERB
dti-1325	185	38	activation	activation	NOUN
dti-1325	185	39	.	.	PUNCT
dti-1325	186	1	in	in	ADP
dti-1325	186	2	addition	addition	NOUN
dti-1325	186	3	,	,	PUNCT
dti-1325	186	4	takagi	takagi	PROPN
dti-1325	186	5	et	et	PROPN
dti-1325	186	6	al	al	PROPN
dti-1325	186	7	.	.	PROPN
dti-1325	186	8	(	(	PUNCT
dti-1325	186	9	2002	2002	NUM
dti-1325	186	10	)	)	PUNCT
dti-1325	186	11	have	have	AUX
dti-1325	186	12	reported	report	VERB
dti-1325	186	13	that	that	SCONJ
dti-1325	186	14	integrins	integrin	NOUN
dti-1325	186	15	,	,	PUNCT
dti-1325	186	16	αvβ3	αvβ3	NOUN
dti-1325	186	17	and	and	CCONJ
dti-1325	186	18	αiibβ3	αiibβ3	PROPN
dti-1325	186	19	,	,	PUNCT
dti-1325	186	20	have	have	VERB
dti-1325	186	21	a	a	DET
dti-1325	186	22	highly	highly	ADV
dti-1325	186	23	bent	bent	ADJ
dti-1325	186	24	conformation	conformation	NOUN
dti-1325	186	25	and	and	CCONJ
dti-1325	186	26	had	have	VERB
dti-1325	186	27	low	low	ADJ
dti-1325	186	28	affinity	affinity	NOUN
dti-1325	186	29	for	for	ADP
dti-1325	186	30	biological	biological	ADJ
dti-1325	186	31	ligands	ligand	NOUN
dti-1325	186	32	under	under	ADP
dti-1325	186	33	physiological	physiological	ADJ
dti-1325	186	34	condition	condition	NOUN
dti-1325	186	35	.	.	PUNCT
dti-1325	187	1	the	the	DET
dti-1325	187	2	addition	addition	NOUN
dti-1325	187	3	of	of	ADP
dti-1325	187	4	mn2	mn2	VERB
dti-1325	187	5	+	+	CCONJ
dti-1325	187	6	resulted	result	VERB
dti-1325	187	7	in	in	ADP
dti-1325	187	8	a	a	DET
dti-1325	187	9	switchblade	switchblade	NOUN
dti-1325	187	10	-	-	PUNCT
dti-1325	187	11	like	like	ADJ
dti-1325	187	12	opening	opening	NOUN
dti-1325	187	13	to	to	ADP
dti-1325	187	14	an	an	DET
dti-1325	187	15	extended	extended	ADJ
dti-1325	187	16	structure	structure	NOUN
dti-1325	187	17	that	that	PRON
dti-1325	187	18	has	have	VERB
dti-1325	187	19	high	high	ADJ
dti-1325	187	20	affinity	affinity	NOUN
dti-1325	187	21	for	for	ADP
dti-1325	187	22	biological	biological	ADJ
dti-1325	187	23	ligands	ligand	NOUN
dti-1325	187	24	.	.	PUNCT
dti-1325	188	1	our	our	PRON
dti-1325	188	2	results	result	NOUN
dti-1325	188	3	are	be	AUX
dti-1325	188	4	consistence	consistence	NOUN
dti-1325	188	5	with	with	ADP
dti-1325	188	6	theirs	theirs	PRON
dti-1325	188	7	in	in	ADP
dti-1325	188	8	that	that	PRON
dti-1325	188	9	upon	upon	SCONJ
dti-1325	188	10	exposure	exposure	NOUN
dti-1325	188	11	to	to	ADP
dti-1325	188	12	mn2	mn2	VERB
dti-1325	188	13	+	+	PROPN
dti-1325	188	14	,	,	PUNCT
dti-1325	188	15	the	the	DET
dti-1325	188	16	αiib	αiib	ADJ
dti-1325	188	17	/	/	SYM
dti-1325	188	18	β3	β3	ADJ
dti-1325	188	19	complex	complex	ADJ
dti-1325	188	20	shifts	shift	NOUN
dti-1325	188	21	from	from	ADP
dti-1325	188	22	its	its	PRON
dti-1325	188	23	inactive	inactive	NOUN
dti-1325	188	24	to	to	ADP
dti-1325	188	25	the	the	DET
dti-1325	188	26	active	active	ADJ
dti-1325	188	27	state	state	NOUN
dti-1325	188	28	as	as	SCONJ
dti-1325	188	29	shown	show	VERB
dti-1325	188	30	by	by	ADP
dti-1325	188	31	the	the	DET
dti-1325	188	32	increase	increase	NOUN
dti-1325	188	33	in	in	ADP
dti-1325	188	34	fitcpac-1	fitcpac-1	NOUN
dti-1325	188	35	binding	bind	VERB
dti-1325	188	36	.	.	PUNCT
dti-1325	189	1	cysteine	cysteine	NOUN
dti-1325	189	2	residues	residue	NOUN
dti-1325	189	3	in	in	ADP
dti-1325	189	4	β3	β3	NOUN
dti-1325	189	5	play	play	VERB
dti-1325	189	6	important	important	ADJ
dti-1325	189	7	roles	role	NOUN
dti-1325	189	8	in	in	ADP
dti-1325	189	9	αiib	αiib	ADJ
dti-1325	189	10	/	/	SYM
dti-1325	189	11	β3	β3	ADJ
dti-1325	189	12	complex	complex	ADJ
dti-1325	189	13	activation	activation	NOUN
dti-1325	189	14	.	.	PUNCT
dti-1325	190	1	sun	sun	PROPN
dti-1325	190	2	et	et	PROPN
dti-1325	190	3	al	al	PROPN
dti-1325	190	4	.	.	PROPN
dti-1325	190	5	(	(	PUNCT
dti-1325	190	6	2002	2002	NUM
dti-1325	190	7	)	)	PUNCT
dti-1325	190	8	reported	report	VERB
dti-1325	190	9	that	that	SCONJ
dti-1325	190	10	disruption	disruption	NOUN
dti-1325	190	11	of	of	ADP
dti-1325	190	12	the	the	DET
dti-1325	190	13	long	long	ADJ
dti-1325	190	14	-	-	PUNCT
dti-1325	190	15	range	range	NOUN
dti-1325	190	16	β3	β3	PROPN
dti-1325	190	17	cys5cys435	cys5cys435	PROPN
dti-1325	190	18	disulfi	disulfi	PROPN
dti-1325	190	19	de	de	X
dti-1325	190	20	bond	bond	NOUN
dti-1325	190	21	resulted	result	VERB
dti-1325	190	22	in	in	ADP
dti-1325	190	23	the	the	DET
dti-1325	190	24	production	production	NOUN
dti-1325	190	25	of	of	ADP
dti-1325	190	26	constitutively	constitutively	ADV
dti-1325	190	27	active	active	ADJ
dti-1325	190	28	αiib	αiib	ADJ
dti-1325	190	29	/	/	SYM
dti-1325	190	30	β3	β3	ADJ
dti-1325	190	31	integrin	integrin	NOUN
dti-1325	190	32	complex	complex	NOUN
dti-1325	190	33	.	.	PUNCT
dti-1325	191	1	another	another	DET
dti-1325	191	2	report	report	NOUN
dti-1325	191	3	proposed	propose	VERB
dti-1325	191	4	that	that	SCONJ
dti-1325	191	5	the	the	DET
dti-1325	191	6	cysteine	cysteine	NOUN
dti-1325	191	7	residues	residue	NOUN
dti-1325	191	8	located	locate	VERB
dti-1325	191	9	from	from	ADP
dti-1325	191	10	616–690	616–690	NUM
dti-1325	191	11	of	of	ADP
dti-1325	191	12	the	the	DET
dti-1325	191	13	carboxyl	carboxyl	NOUN
dti-1325	191	14	-	-	PUNCT
dti-1325	191	15	terminal	terminal	ADJ
dti-1325	191	16	region	region	NOUN
dti-1325	191	17	was	be	AUX
dti-1325	191	18	important	important	ADJ
dti-1325	191	19	in	in	ADP
dti-1325	191	20	enhancing	enhance	VERB
dti-1325	191	21	ligand	ligand	NOUN
dti-1325	191	22	binding	bind	VERB
dti-1325	191	23	(	(	PUNCT
dti-1325	191	24	butta	butta	NOUN
dti-1325	191	25	et	et	PROPN
dti-1325	191	26	al	al	PROPN
dti-1325	191	27	.	.	PROPN
dti-1325	191	28	2003	2003	NUM
dti-1325	191	29	)	)	PUNCT
dti-1325	191	30	.	.	PUNCT
dti-1325	192	1	kashiwagi	kashiwagi	PROPN
dti-1325	192	2	et	et	PROPN
dti-1325	192	3	al	al	PROPN
dti-1325	192	4	.	.	PROPN
dti-1325	192	5	(	(	PUNCT
dti-1325	192	6	1999	1999	NUM
dti-1325	192	7	)	)	PUNCT
dti-1325	192	8	found	find	VERB
dti-1325	192	9	that	that	SCONJ
dti-1325	192	10	disrupting	disrupt	VERB
dti-1325	192	11	only	only	ADV
dti-1325	192	12	a	a	DET
dti-1325	192	13	single	single	ADJ
dti-1325	192	14	disulfi	disulfi	NOUN
dti-1325	192	15	de	de	X
dti-1325	192	16	bond	bond	NOUN
dti-1325	192	17	in	in	ADP
dti-1325	192	18	the	the	DET
dti-1325	192	19	cysteine	cysteine	NOUN
dti-1325	192	20	-	-	PUNCT
dti-1325	192	21	rich	rich	ADJ
dti-1325	192	22	repeat	repeat	NOUN
dti-1325	192	23	region	region	NOUN
dti-1325	192	24	of	of	ADP
dti-1325	192	25	β3	β3	PROPN
dti-1325	192	26	was	be	AUX
dti-1325	192	27	enough	enough	ADJ
dti-1325	192	28	to	to	PART
dti-1325	192	29	activate	activate	VERB
dti-1325	192	30	αiib	αiib	NOUN
dti-1325	192	31	/	/	SYM
dti-1325	192	32	β3	β3	ADJ
dti-1325	192	33	.	.	PUNCT
dti-1325	193	1	the	the	DET
dti-1325	193	2	p4	p4	ADJ
dti-1325	193	3	peptide	peptide	NOUN
dti-1325	193	4	,	,	PUNCT
dti-1325	193	5	which	which	PRON
dti-1325	193	6	we	we	PRON
dti-1325	193	7	have	have	VERB
dti-1325	193	8	identifi	identifi	PROPN
dti-1325	193	9	ed	ed	NOUN
dti-1325	193	10	is	be	AUX
dti-1325	193	11	present	present	ADJ
dti-1325	193	12	within	within	ADP
dti-1325	193	13	the	the	DET
dti-1325	193	14	cysteine	cysteine	NOUN
dti-1325	193	15	-	-	PUNCT
dti-1325	193	16	rich	rich	ADJ
dti-1325	193	17	region	region	NOUN
dti-1325	193	18	of	of	ADP
dti-1325	193	19	β3	β3	PROPN
dti-1325	193	20	and	and	CCONJ
dti-1325	193	21	contains	contain	VERB
dti-1325	193	22	two	two	NUM
dti-1325	193	23	cysteine	cysteine	NOUN
dti-1325	193	24	residues	residue	NOUN
dti-1325	193	25	,	,	PUNCT
dti-1325	193	26	which	which	PRON
dti-1325	193	27	may	may	AUX
dti-1325	193	28	form	form	VERB
dti-1325	193	29	a	a	DET
dti-1325	193	30	disulfi	disulfi	NOUN
dti-1325	193	31	de	de	X
dti-1325	193	32	bond	bond	NOUN
dti-1325	193	33	with	with	ADP
dti-1325	193	34	other	other	ADJ
dti-1325	193	35	cysteines	cysteine	NOUN
dti-1325	193	36	of	of	ADP
dti-1325	193	37	αiib	αiib	NOUN
dti-1325	193	38	.	.	PUNCT
dti-1325	194	1	we	we	PRON
dti-1325	194	2	used	use	VERB
dti-1325	194	3	the	the	DET
dti-1325	194	4	dipro	dipro	ADJ
dti-1325	194	5	2.0	2.0	NUM
dti-1325	194	6	software	software	NOUN
dti-1325	194	7	to	to	PART
dti-1325	194	8	predict	predict	VERB
dti-1325	194	9	the	the	DET
dti-1325	194	10	location	location	NOUN
dti-1325	194	11	,	,	PUNCT
dti-1325	194	12	which	which	PRON
dti-1325	194	13	the	the	DET
dti-1325	194	14	disulfi	disulfi	PROPN
dti-1325	194	15	de	de	ADP
dti-1325	194	16	bond	bond	NOUN
dti-1325	194	17	formation	formation	NOUN
dti-1325	194	18	would	would	AUX
dti-1325	194	19	reoccur	reoccur	VERB
dti-1325	194	20	(	(	PUNCT
dti-1325	194	21	cheng	cheng	PROPN
dti-1325	194	22	et	et	PROPN
dti-1325	194	23	al	al	PROPN
dti-1325	194	24	.	.	PROPN
dti-1325	194	25	2006	2006	NUM
dti-1325	194	26	)	)	PUNCT
dti-1325	194	27	.	.	PUNCT
dti-1325	195	1	according	accord	VERB
dti-1325	195	2	to	to	ADP
dti-1325	195	3	the	the	DET
dti-1325	195	4	software	software	NOUN
dti-1325	195	5	results	result	NOUN
dti-1325	195	6	of	of	ADP
dti-1325	195	7	proposed	propose	VERB
dti-1325	195	8	β3	β3	PROPN
dti-1325	195	9	-	-	PUNCT
dti-1325	195	10	mut	mut	NOUN
dti-1325	195	11	,	,	PUNCT
dti-1325	195	12	the	the	DET
dti-1325	195	13	predicted	predict	VERB
dti-1325	195	14	disulfi	disulfi	PROPN
dti-1325	195	15	de	de	X
dti-1325	195	16	bridge	bridge	NOUN
dti-1325	195	17	reforms	reform	NOUN
dti-1325	195	18	at	at	ADP
dti-1325	195	19	513–527	513–527	NUM
dti-1325	195	20	.	.	PUNCT
dti-1325	196	1	altering	alter	VERB
dti-1325	196	2	the	the	DET
dti-1325	196	3	positions	position	NOUN
dti-1325	196	4	of	of	ADP
dti-1325	196	5	these	these	DET
dti-1325	196	6	two	two	NUM
dti-1325	196	7	cysteine	cysteine	NOUN
dti-1325	196	8	residues	residue	NOUN
dti-1325	196	9	may	may	AUX
dti-1325	196	10	affect	affect	VERB
dti-1325	196	11	the	the	DET
dti-1325	196	12	ability	ability	NOUN
dti-1325	196	13	of	of	ADP
dti-1325	196	14	mn2	mn2	VERB
dti-1325	196	15	+	+	CCONJ
dti-1325	196	16	to	to	PART
dti-1325	196	17	activate	activate	VERB
dti-1325	196	18	αiib	αiib	NOUN
dti-1325	196	19	/	/	SYM
dti-1325	196	20	β3	β3	ADJ
dti-1325	196	21	.	.	PUNCT
dti-1325	197	1	the	the	DET
dti-1325	197	2	β3	β3	ADJ
dti-1325	197	3	-	-	PUNCT
dti-1325	197	4	mut	mut	NOUN
dti-1325	197	5	cdna	cdna	PROPN
dti-1325	197	6	we	we	PRON
dti-1325	197	7	created	create	VERB
dti-1325	197	8	and	and	CCONJ
dti-1325	197	9	expressed	express	VERB
dti-1325	197	10	in	in	ADP
dti-1325	197	11	cho	cho	PROPN
dti-1325	197	12	cells	cell	NOUN
dti-1325	197	13	was	be	AUX
dti-1325	197	14	not	not	PART
dti-1325	197	15	clearly	clearly	ADV
dti-1325	197	16	defi	defi	VERB
dti-1325	197	17	ned	ne	VERB
dti-1325	197	18	by	by	ADP
dti-1325	197	19	coomassie	coomassie	ADJ
dti-1325	197	20	brilliant	brilliant	ADJ
dti-1325	197	21	blue	blue	ADJ
dti-1325	197	22	stained	stain	VERB
dti-1325	197	23	sds	sds	NOUN
dti-1325	197	24	-	-	PUNCT
dti-1325	197	25	page	page	NOUN
dti-1325	197	26	or	or	CCONJ
dti-1325	197	27	by	by	ADP
dti-1325	197	28	immunoblot	immunoblot	NOUN
dti-1325	197	29	analysis	analysis	NOUN
dti-1325	197	30	with	with	ADP
dti-1325	197	31	an	an	DET
dti-1325	197	32	anti	anti	ADJ
dti-1325	197	33	-	-	ADJ
dti-1325	197	34	β3	β3	ADJ
dti-1325	197	35	monoclonal	monoclonal	NOUN
dti-1325	197	36	antibody	antibody	NOUN
dti-1325	197	37	(	(	PUNCT
dti-1325	197	38	fig	fig	NOUN
dti-1325	197	39	.	.	PUNCT
dti-1325	198	1	1	1	NUM
dti-1325	198	2	,	,	PUNCT
dti-1325	198	3	panel	panel	NOUN
dti-1325	198	4	b	b	NOUN
dti-1325	198	5	,	,	PUNCT
dti-1325	198	6	lane3	lane3	PROPN
dti-1325	198	7	)	)	PUNCT
dti-1325	198	8	.	.	PUNCT
dti-1325	199	1	however	however	ADV
dti-1325	199	2	,	,	PUNCT
dti-1325	199	3	with	with	ADP
dti-1325	199	4	flow	flow	NOUN
dti-1325	199	5	cytometry	cytometry	NOUN
dti-1325	199	6	,	,	PUNCT
dti-1325	199	7	we	we	PRON
dti-1325	199	8	observed	observe	VERB
dti-1325	199	9	the	the	DET
dti-1325	199	10	presence	presence	NOUN
dti-1325	199	11	of	of	ADP
dti-1325	199	12	the	the	DET
dti-1325	199	13	inactive	inactive	ADJ
dti-1325	199	14	complex	complex	NOUN
dti-1325	199	15	of	of	ADP
dti-1325	199	16	αiib	αiib	NOUN
dti-1325	199	17	/	/	SYM
dti-1325	199	18	β3	β3	PROPN
dti-1325	199	19	-	-	PUNCT
dti-1325	199	20	mut	mut	NOUN
dti-1325	199	21	with	with	ADP
dti-1325	199	22	ap2	ap2	PROPN
dti-1325	199	23	(	(	PUNCT
dti-1325	199	24	an	an	DET
dti-1325	199	25	antibody	antibody	NOUN
dti-1325	199	26	,	,	PUNCT
dti-1325	199	27	which	which	PRON
dti-1325	199	28	recognizes	recognize	VERB
dti-1325	199	29	the	the	DET
dti-1325	199	30	αiib	αiib	ADJ
dti-1325	199	31	/	/	SYM
dti-1325	199	32	β3	β3	ADJ
dti-1325	199	33	inactive	inactive	ADJ
dti-1325	199	34	complex	complex	NOUN
dti-1325	199	35	)	)	PUNCT
dti-1325	199	36	.	.	PUNCT
dti-1325	200	1	the	the	DET
dti-1325	200	2	percentage	percentage	NOUN
dti-1325	200	3	-	-	PUNCT
dti-1325	200	4	gated	gate	VERB
dti-1325	200	5	subset	subset	NOUN
dti-1325	200	6	of	of	ADP
dti-1325	200	7	ap2	ap2	PROPN
dti-1325	200	8	binding	bind	VERB
dti-1325	200	9	was	be	AUX
dti-1325	200	10	similar	similar	ADJ
dti-1325	200	11	between	between	ADP
dti-1325	200	12	the	the	DET
dti-1325	200	13	two	two	NUM
dti-1325	200	14	different	different	ADJ
dti-1325	200	15	stable	stable	ADJ
dti-1325	200	16	lines	line	NOUN
dti-1325	200	17	αiib	αiib	VERB
dti-1325	200	18	/	/	SYM
dti-1325	200	19	β3	β3	ADJ
dti-1325	200	20	and	and	CCONJ
dti-1325	200	21	αiib	αiib	ADJ
dti-1325	200	22	/	/	SYM
dti-1325	200	23	β3	β3	ADJ
dti-1325	200	24	-	-	PUNCT
dti-1325	200	25	mut	mut	NOUN
dti-1325	200	26	.	.	PUNCT
dti-1325	201	1	these	these	DET
dti-1325	201	2	results	result	NOUN
dti-1325	201	3	indicate	indicate	VERB
dti-1325	201	4	that	that	SCONJ
dti-1325	201	5	expression	expression	NOUN
dti-1325	201	6	and	and	CCONJ
dti-1325	201	7	transport	transport	NOUN
dti-1325	201	8	of	of	ADP
dti-1325	201	9	the	the	DET
dti-1325	201	10	αiib	αiib	NOUN
dti-1325	201	11	/	/	SYM
dti-1325	201	12	β3	β3	ADJ
dti-1325	201	13	-	-	PUNCT
dti-1325	201	14	mut	mut	NOUN
dti-1325	201	15	proteins	protein	NOUN
dti-1325	201	16	to	to	ADP
dti-1325	201	17	the	the	DET
dti-1325	201	18	cell	cell	NOUN
dti-1325	201	19	surface	surface	NOUN
dti-1325	201	20	does	do	AUX
dti-1325	201	21	occur	occur	VERB
dti-1325	201	22	.	.	PUNCT
dti-1325	202	1	the	the	DET
dti-1325	202	2	poor	poor	ADJ
dti-1325	202	3	immunoblot	immunoblot	NOUN
dti-1325	202	4	result	result	NOUN
dti-1325	202	5	of	of	ADP
dti-1325	202	6	β3	β3	ADJ
dti-1325	202	7	-	-	PUNCT
dti-1325	202	8	mut	mut	NOUN
dti-1325	202	9	may	may	AUX
dti-1325	202	10	be	be	AUX
dti-1325	202	11	a	a	DET
dti-1325	202	12	consequence	consequence	NOUN
dti-1325	202	13	of	of	ADP
dti-1325	202	14	the	the	DET
dti-1325	202	15	inability	inability	NOUN
dti-1325	202	16	of	of	ADP
dti-1325	202	17	the	the	DET
dti-1325	202	18	antibody	antibody	NOUN
dti-1325	202	19	to	to	PART
dti-1325	202	20	recognize	recognize	VERB
dti-1325	202	21	the	the	DET
dti-1325	202	22	mutated	mutate	VERB
dti-1325	202	23	sequence	sequence	NOUN
dti-1325	202	24	of	of	ADP
dti-1325	202	25	amino	amino	NOUN
dti-1325	202	26	acid	acid	NOUN
dti-1325	202	27	residues	residue	NOUN
dti-1325	202	28	.	.	PUNCT
dti-1325	203	1	the	the	DET
dti-1325	203	2	αiibβ3	αiibβ3	PROPN
dti-1325	203	3	-	-	PUNCT
dti-1325	203	4	mut	mut	PROPN
dti-1325	203	5	cdna	cdna	PROPN
dti-1325	203	6	expressed	express	VERB
dti-1325	203	7	in	in	ADP
dti-1325	203	8	cho	cho	PROPN
dti-1325	203	9	cells	cell	NOUN
dti-1325	203	10	did	do	AUX
dti-1325	203	11	not	not	PART
dti-1325	203	12	show	show	VERB
dti-1325	203	13	strong	strong	ADJ
dti-1325	203	14	activation	activation	NOUN
dti-1325	203	15	of	of	ADP
dti-1325	203	16	the	the	DET
dti-1325	203	17	inactive	inactive	ADJ
dti-1325	203	18	complex	complex	NOUN
dti-1325	203	19	with	with	ADP
dti-1325	203	20	the	the	DET
dti-1325	203	21	addition	addition	NOUN
dti-1325	203	22	of	of	ADP
dti-1325	203	23	mn2	mn2	NOUN
dti-1325	203	24	+	+	PROPN
dti-1325	203	25	.	.	PUNCT
dti-1325	204	1	our	our	PRON
dti-1325	204	2	results	result	NOUN
dti-1325	204	3	of	of	ADP
dti-1325	204	4	substitution	substitution	NOUN
dti-1325	204	5	of	of	ADP
dti-1325	204	6	c499a	c499a	PROPN
dti-1325	204	7	and	and	CCONJ
dti-1325	204	8	c512a	c512a	PROPN
dti-1325	204	9	75	75	NUM
dti-1325	204	10	the	the	DET
dti-1325	204	11	beta3	beta3	X
dti-1325	204	12	499–513	499–513	NUM
dti-1325	204	13	peptide	peptide	NOUN
dti-1325	204	14	region	region	NOUN
dti-1325	204	15	is	be	AUX
dti-1325	204	16	required	require	VERB
dti-1325	204	17	for	for	ADP
dti-1325	204	18	alphaiib	alphaiib	ADJ
dti-1325	204	19	/	/	SYM
dti-1325	204	20	beta3	beta3	NOUN
dti-1325	204	21	active	active	ADJ
dti-1325	204	22	complex	complex	ADJ
dti-1325	204	23	drug	drug	NOUN
dti-1325	204	24	target	target	NOUN
dti-1325	204	25	insights	insight	NOUN
dti-1325	204	26	2008:3	2008:3	NUM
dti-1325	204	27	resulted	result	VERB
dti-1325	204	28	in	in	ADP
dti-1325	204	29	less	less	ADJ
dti-1325	204	30	pac-1	pac-1	NOUN
dti-1325	204	31	binding	bind	VERB
dti-1325	204	32	suggesting	suggest	VERB
dti-1325	204	33	these	these	DET
dti-1325	204	34	two	two	NUM
dti-1325	204	35	cysteines	cysteine	NOUN
dti-1325	204	36	are	be	AUX
dti-1325	204	37	also	also	ADV
dti-1325	204	38	important	important	ADJ
dti-1325	204	39	.	.	PUNCT
dti-1325	205	1	integrins	integrin	NOUN
dti-1325	205	2	have	have	AUX
dti-1325	205	3	become	become	VERB
dti-1325	205	4	attractive	attractive	ADJ
dti-1325	205	5	therapeutic	therapeutic	ADJ
dti-1325	205	6	targets	target	NOUN
dti-1325	205	7	.	.	PUNCT
dti-1325	206	1	many	many	ADJ
dti-1325	206	2	drugs	drug	NOUN
dti-1325	206	3	,	,	PUNCT
dti-1325	206	4	which	which	PRON
dti-1325	206	5	inhibit	inhibit	VERB
dti-1325	206	6	integrin	integrin	NOUN
dti-1325	206	7	αiib/	αiib/	NUM
dti-1325	206	8	β3	β3	ADJ
dti-1325	206	9	binding	bind	VERB
dti-1325	206	10	can	can	AUX
dti-1325	206	11	effectively	effectively	ADV
dti-1325	206	12	block	block	VERB
dti-1325	206	13	agonists	agonist	NOUN
dti-1325	206	14	induced	induce	VERB
dti-1325	206	15	platelet	platelet	NOUN
dti-1325	206	16	aggregation	aggregation	NOUN
dti-1325	206	17	in	in	ADP
dti-1325	206	18	vitro	vitro	X
dti-1325	206	19	.	.	PUNCT
dti-1325	207	1	however	however	ADV
dti-1325	207	2	,	,	PUNCT
dti-1325	207	3	intravenous	intravenous	ADJ
dti-1325	207	4	infusion	infusion	NOUN
dti-1325	207	5	or	or	CCONJ
dti-1325	207	6	oral	oral	ADJ
dti-1325	207	7	ingestion	ingestion	NOUN
dti-1325	207	8	of	of	ADP
dti-1325	207	9	these	these	DET
dti-1325	207	10	drugs	drug	NOUN
dti-1325	207	11	failed	fail	VERB
dti-1325	207	12	to	to	PART
dti-1325	207	13	effectively	effectively	ADV
dti-1325	207	14	block	block	VERB
dti-1325	207	15	pathological	pathological	ADJ
dti-1325	207	16	thrombosis	thrombosis	NOUN
dti-1325	207	17	in	in	ADP
dti-1325	207	18	certain	certain	ADJ
dti-1325	207	19	patients	patient	NOUN
dti-1325	207	20	.	.	PUNCT
dti-1325	208	1	this	this	PRON
dti-1325	208	2	raises	raise	VERB
dti-1325	208	3	a	a	DET
dti-1325	208	4	question	question	NOUN
dti-1325	208	5	of	of	ADP
dti-1325	208	6	“	"	PUNCT
dti-1325	208	7	how	how	SCONJ
dti-1325	208	8	effective	effective	ADJ
dti-1325	208	9	is	be	AUX
dti-1325	208	10	the	the	DET
dti-1325	208	11	ligand	ligand	NOUN
dti-1325	208	12	-	-	PUNCT
dti-1325	208	13	mimetic	mimetic	ADJ
dti-1325	208	14	integrin	integrin	NOUN
dti-1325	208	15	blockade	blockade	NOUN
dti-1325	208	16	?	?	PUNCT
dti-1325	208	17	”	"	PUNCT
dti-1325	209	1	our	our	PRON
dti-1325	209	2	results	result	NOUN
dti-1325	209	3	demonstrates	demonstrate	VERB
dti-1325	209	4	that	that	SCONJ
dti-1325	209	5	the	the	DET
dti-1325	209	6	p4	p4	ADJ
dti-1325	209	7	peptide	peptide	NOUN
dti-1325	209	8	is	be	AUX
dti-1325	209	9	important	important	ADJ
dti-1325	209	10	for	for	ADP
dti-1325	209	11	interfering	interfere	VERB
dti-1325	209	12	with	with	ADP
dti-1325	209	13	αiib	αiib	ADJ
dti-1325	209	14	/	/	SYM
dti-1325	209	15	β3	β3	NOUN
dti-1325	209	16	activation	activation	NOUN
dti-1325	209	17	,	,	PUNCT
dti-1325	209	18	thus	thus	ADV
dti-1325	209	19	inhibiting	inhibit	VERB
dti-1325	209	20	binding	binding	NOUN
dti-1325	209	21	of	of	ADP
dti-1325	209	22	fi	fi	NOUN
dti-1325	209	23	brinogen	brinogen	NOUN
dti-1325	209	24	on	on	ADP
dti-1325	209	25	activated	activate	VERB
dti-1325	209	26	platelets	platelet	NOUN
dti-1325	209	27	and	and	CCONJ
dti-1325	209	28	platelet	platelet	NOUN
dti-1325	209	29	aggregation	aggregation	NOUN
dti-1325	209	30	in	in	ADP
dti-1325	209	31	vitro	vitro	X
dti-1325	209	32	,	,	PUNCT
dti-1325	209	33	may	may	AUX
dti-1325	209	34	be	be	AUX
dti-1325	209	35	another	another	DET
dti-1325	209	36	candidate	candidate	NOUN
dti-1325	209	37	as	as	ADP
dti-1325	209	38	a	a	DET
dti-1325	209	39	therapeutic	therapeutic	ADJ
dti-1325	209	40	agent	agent	NOUN
dti-1325	209	41	.	.	PUNCT
dti-1325	210	1	however	however	ADV
dti-1325	210	2	,	,	PUNCT
dti-1325	210	3	its	its	PRON
dti-1325	210	4	functional	functional	ADJ
dti-1325	210	5	signifi	signifi	NOUN
dti-1325	210	6	cance	cance	NOUN
dti-1325	210	7	in	in	ADP
dti-1325	210	8	vivo	vivo	NOUN
dti-1325	210	9	is	be	AUX
dti-1325	210	10	not	not	PART
dti-1325	210	11	clear	clear	ADJ
dti-1325	210	12	and	and	CCONJ
dti-1325	210	13	requires	require	VERB
dti-1325	210	14	further	further	ADJ
dti-1325	210	15	investigation	investigation	NOUN
dti-1325	210	16	.	.	PUNCT
dti-1325	211	1	acknowledgements	acknowledgement	NOUN
dti-1325	211	2	the	the	DET
dti-1325	211	3	authors	author	NOUN
dti-1325	211	4	wish	wish	VERB
dti-1325	211	5	to	to	PART
dti-1325	211	6	thank	thank	VERB
dti-1325	211	7	mrs	mrs	PROPN
dti-1325	211	8	.	.	PROPN
dti-1325	211	9	x.	x.	PROPN
dti-1325	211	10	r.	r.	PROPN
dti-1325	211	11	fang	fang	PROPN
dti-1325	211	12	for	for	ADP
dti-1325	211	13	her	her	PRON
dti-1325	211	14	expert	expert	NOUN
dti-1325	211	15	technical	technical	ADJ
dti-1325	211	16	assistance	assistance	NOUN
dti-1325	211	17	,	,	PUNCT
dti-1325	211	18	dr	dr	PROPN
dti-1325	211	19	zhu	zhu	PROPN
dti-1325	211	20	for	for	ADP
dti-1325	211	21	discussion	discussion	NOUN
dti-1325	211	22	,	,	PUNCT
dti-1325	211	23	and	and	CCONJ
dti-1325	211	24	dr	dr	PROPN
dti-1325	211	25	.	.	PROPN
dti-1325	211	26	peter	peter	PROPN
dti-1325	211	27	newman	newman	PROPN
dti-1325	211	28	,	,	PUNCT
dti-1325	211	29	the	the	DET
dti-1325	211	30	blood	blood	NOUN
dti-1325	211	31	center	center	NOUN
dti-1325	211	32	of	of	ADP
dti-1325	211	33	southeastern	southeastern	PROPN
dti-1325	211	34	wisconsin	wisconsin	PROPN
dti-1325	211	35	,	,	PUNCT
dti-1325	211	36	inc	inc	PROPN
dti-1325	211	37	.	.	PROPN
dti-1325	211	38	milwaukee	milwaukee	PROPN
dti-1325	211	39	,	,	PUNCT
dti-1325	211	40	wi	wi	PROPN
dti-1325	211	41	for	for	ADP
dti-1325	211	42	a	a	DET
dti-1325	211	43	αiib	αiib	ADJ
dti-1325	211	44	construct	construct	NOUN
dti-1325	211	45	.	.	PUNCT
dti-1325	212	1	the	the	DET
dti-1325	212	2	offi	offi	PROPN
dti-1325	212	3	ce	ce	PROPN
dti-1325	212	4	of	of	ADP
dti-1325	212	5	biomedical	biomedical	ADJ
dti-1325	212	6	laboratory	laboratory	NOUN
dti-1325	212	7	research	research	NOUN
dti-1325	212	8	,	,	PUNCT
dti-1325	212	9	department	department	NOUN
dti-1325	212	10	of	of	ADP
dti-1325	212	11	veterans	veterans	PROPN
dti-1325	212	12	affairs	affairs	PROPN
dti-1325	212	13	supported	support	VERB
dti-1325	212	14	the	the	DET
dti-1325	212	15	present	present	ADJ
dti-1325	212	16	investigation	investigation	NOUN
dti-1325	212	17	.	.	PUNCT
dti-1325	213	1	abbreviations	abbreviation	NOUN
dti-1325	213	2	prp	prp	NOUN
dti-1325	213	3	,	,	PUNCT
dti-1325	213	4	platelet	platelet	ADJ
dti-1325	213	5	-	-	PUNCT
dti-1325	213	6	rich	rich	ADJ
dti-1325	213	7	plasma	plasma	NOUN
dti-1325	213	8	;	;	PUNCT
dti-1325	213	9	tris	tris	NOUN
dti-1325	213	10	-	-	PUNCT
dti-1325	213	11	edta	edta	NOUN
dti-1325	213	12	,	,	PUNCT
dti-1325	213	13	20	20	NUM
dti-1325	213	14	mm	mm	NOUN
dti-1325	213	15	tris	tris	NOUN
dti-1325	213	16	-	-	PUNCT
dti-1325	213	17	hcl-130	hcl-130	NOUN
dti-1325	213	18	mm	mm	PROPN
dti-1325	213	19	nacl-1	nacl-1	NUM
dti-1325	213	20	mm	mm	PROPN
dti-1325	213	21	edta	edta	NOUN
dti-1325	213	22	,	,	PUNCT
dti-1325	213	23	ph	ph	VERB
dti-1325	213	24	7.4	7.4	NUM
dti-1325	213	25	;	;	PUNCT
dti-1325	213	26	tyrode	tyrode	NOUN
dti-1325	213	27	’s	’s	PART
dti-1325	213	28	buffer	buffer	NOUN
dti-1325	213	29	,	,	PUNCT
dti-1325	213	30	5	5	NUM
dti-1325	213	31	mm	mm	NOUN
dti-1325	213	32	hepes	hepe	NOUN
dti-1325	213	33	,	,	PUNCT
dti-1325	213	34	2	2	NUM
dti-1325	213	35	mm	mm	NOUN
dti-1325	213	36	mgcl2	mgcl2	PROPN
dti-1325	213	37	,	,	PUNCT
dti-1325	213	38	0.3	0.3	NUM
dti-1325	213	39	mm	mm	PROPN
dti-1325	213	40	nah2po4	nah2po4	PROPN
dti-1325	213	41	,	,	PUNCT
dti-1325	213	42	3	3	NUM
dti-1325	213	43	mm	mm	NOUN
dti-1325	213	44	kcl	kcl	PROPN
dti-1325	213	45	,	,	PUNCT
dti-1325	213	46	12	12	NUM
dti-1325	213	47	mm	mm	NUM
dti-1325	213	48	nahco3	nahco3	NOUN
dti-1325	213	49	,	,	PUNCT
dti-1325	213	50	0.1	0.1	NUM
dti-1325	213	51	%	%	NOUN
dti-1325	213	52	glucose	glucose	NOUN
dti-1325	213	53	,	,	PUNCT
dti-1325	213	54	0.1	0.1	NUM
dti-1325	213	55	%	%	NOUN
dti-1325	213	56	bsa	bsa	NOUN
dti-1325	213	57	,	,	PUNCT
dti-1325	213	58	and	and	CCONJ
dti-1325	213	59	1	1	NUM
dti-1325	213	60	mm	mm	NOUN
dti-1325	213	61	cacl2	cacl2	NOUN
dti-1325	213	62	,	,	PUNCT
dti-1325	213	63	ph	ph	NOUN
dti-1325	213	64	7.0	7.0	NUM
dti-1325	213	65	;	;	PUNCT
dti-1325	213	66	(	(	PUNCT
dti-1325	213	67	hepes	hepe	NOUN
dti-1325	213	68	buffer	buffer	NOUN
dti-1325	213	69	,	,	PUNCT
dti-1325	214	1	50	50	NUM
dti-1325	214	2	mm	mm	NOUN
dti-1325	214	3	hepes/1	hepes/1	NUM
dti-1325	215	1	%	%	NOUN
dti-1325	216	1	glucose/2	glucose/2	PROPN
dti-1325	216	2	mm	mm	PROPN
dti-1325	216	3	ca2+/2	ca2+/2	PROPN
dti-1325	216	4	mm	mm	PROPN
dti-1325	216	5	mg2	mg2	PROPN
dti-1325	216	6	+	+	PROPN
dti-1325	216	7	ph	ph	ADJ
dti-1325	216	8	7.4	7.4	NUM
dti-1325	216	9	;	;	PUNCT
dti-1325	216	10	fitc	fitc	NOUN
dti-1325	216	11	-	-	PUNCT
dti-1325	216	12	pac-1	pac-1	NOUN
dti-1325	216	13	,	,	PUNCT
dti-1325	216	14	fluroscence	fluroscence	NOUN
dti-1325	216	15	isothiocyanate	isothiocyanate	NOUN
dti-1325	216	16	conjugated	conjugate	VERB
dti-1325	216	17	anti	anti	ADJ
dti-1325	216	18	-	-	ADJ
dti-1325	216	19	gp	gp	ADJ
dti-1325	216	20	iib	iib	NOUN
dti-1325	216	21	/	/	SYM
dti-1325	216	22	iiia	iiia	NOUN
dti-1325	216	23	;	;	PUNCT
dti-1325	216	24	and	and	CCONJ
dti-1325	216	25	cho	cho	PROPN
dti-1325	216	26	,	,	PUNCT
dti-1325	216	27	chinese	chinese	ADJ
dti-1325	216	28	hamster	hamster	NOUN
dti-1325	216	29	ovary	ovary	ADJ
dti-1325	216	30	cell	cell	NOUN
dti-1325	216	31	.	.	PUNCT
dti-1325	217	1	references	reference	NOUN
dti-1325	217	2	beglova	beglova	PROPN
dti-1325	217	3	,	,	PUNCT
dti-1325	217	4	n.	n.	NOUN
dti-1325	217	5	,	,	PUNCT
dti-1325	217	6	blacklow	blacklow	NOUN
dti-1325	217	7	,	,	PUNCT
dti-1325	217	8	s.c	s.c	PROPN
dti-1325	217	9	.	.	PROPN
dti-1325	217	10	,	,	PUNCT
dti-1325	217	11	takagi	takagi	PROPN
dti-1325	217	12	,	,	PUNCT
dti-1325	217	13	j.	j.	PROPN
dti-1325	217	14	and	and	CCONJ
dti-1325	217	15	springer	springer	PROPN
dti-1325	217	16	,	,	PUNCT
dti-1325	217	17	t.a	t.a	PROPN
dti-1325	217	18	.	.	PROPN
dti-1325	217	19	2002	2002	NUM
dti-1325	217	20	.	.	PUNCT
dti-1325	218	1	cysteinerich	cysteinerich	NOUN
dti-1325	218	2	module	module	NOUN
dti-1325	218	3	structure	structure	NOUN
dti-1325	218	4	reveals	reveal	VERB
dti-1325	218	5	a	a	DET
dti-1325	218	6	fulcrum	fulcrum	NOUN
dti-1325	218	7	for	for	ADP
dti-1325	218	8	integrin	integrin	NOUN
dti-1325	218	9	rearrangement	rearrangement	NOUN
dti-1325	218	10	upon	upon	SCONJ
dti-1325	218	11	activation	activation	NOUN
dti-1325	218	12	.	.	PUNCT
dti-1325	219	1	nat	nat	NOUN
dti-1325	219	2	.	.	PUNCT
dti-1325	219	3	struct	struct	NOUN
dti-1325	219	4	.	.	PUNCT
dti-1325	220	1	biol	biol	PROPN
dti-1325	220	2	.	.	PUNCT
dti-1325	220	3	,	,	PUNCT
dti-1325	220	4	9:282–7	9:282–7	X
dti-1325	220	5	.	.	PUNCT
dti-1325	220	6	blystone	blystone	NOUN
dti-1325	220	7	,	,	PUNCT
dti-1325	220	8	s.d	s.d	PROPN
dti-1325	220	9	.	.	PROPN
dti-1325	220	10	,	,	PUNCT
dti-1325	220	11	lindberg	lindberg	PROPN
dti-1325	220	12	,	,	PUNCT
dti-1325	220	13	f.p	f.p	PROPN
dti-1325	220	14	.	.	PROPN
dti-1325	220	15	,	,	PUNCT
dti-1325	220	16	laflamme	laflamme	PROPN
dti-1325	220	17	,	,	PUNCT
dti-1325	220	18	s.e	s.e	PROPN
dti-1325	220	19	.	.	PROPN
dti-1325	220	20	and	and	CCONJ
dti-1325	220	21	brown	brown	PROPN
dti-1325	220	22	,	,	PUNCT
dti-1325	220	23	e.j	e.j	PROPN
dti-1325	220	24	.	.	PROPN
dti-1325	220	25	1995	1995	NUM
dti-1325	220	26	.	.	PUNCT
dti-1325	221	1	integrin	integrin	NOUN
dti-1325	221	2	beta	beta	NOUN
dti-1325	221	3	3	3	NUM
dti-1325	221	4	cytoplasmic	cytoplasmic	ADJ
dti-1325	221	5	tail	tail	NOUN
dti-1325	221	6	is	be	AUX
dti-1325	221	7	necessary	necessary	ADJ
dti-1325	221	8	and	and	CCONJ
dti-1325	221	9	suffi	suffi	NOUN
dti-1325	221	10	cient	cient	NOUN
dti-1325	221	11	for	for	ADP
dti-1325	221	12	regulation	regulation	NOUN
dti-1325	221	13	of	of	ADP
dti-1325	221	14	alpha	alpha	NOUN
dti-1325	221	15	5	5	NUM
dti-1325	221	16	beta	beta	NOUN
dti-1325	221	17	1	1	NUM
dti-1325	221	18	phagocytosis	phagocytosis	NOUN
dti-1325	221	19	by	by	ADP
dti-1325	221	20	alpha	alpha	NOUN
dti-1325	221	21	v	v	ADP
dti-1325	221	22	beta	beta	NOUN
dti-1325	221	23	3	3	NUM
dti-1325	221	24	and	and	CCONJ
dti-1325	221	25	integrinassociated	integrinassociated	ADJ
dti-1325	221	26	protein	protein	NOUN
dti-1325	221	27	.	.	PUNCT
dti-1325	222	1	j.	j.	PROPN
dti-1325	222	2	cell	cell	PROPN
dti-1325	222	3	biol	biol	PROPN
dti-1325	222	4	.	.	PUNCT
dti-1325	222	5	,	,	PUNCT
dti-1325	222	6	130:745–54	130:745–54	NUM
dti-1325	222	7	.	.	PUNCT
dti-1325	223	1	butta	butta	NOUN
dti-1325	223	2	,	,	PUNCT
dti-1325	223	3	n.	n.	NOUN
dti-1325	223	4	,	,	PUNCT
dti-1325	223	5	arias	arias	PROPN
dti-1325	223	6	-	-	PUNCT
dti-1325	223	7	salgado	salgado	PROPN
dti-1325	223	8	,	,	PUNCT
dti-1325	223	9	e.g.	e.g.	ADV
dti-1325	223	10	,	,	PUNCT
dti-1325	223	11	gonzalez	gonzalez	PROPN
dti-1325	223	12	-	-	PUNCT
dti-1325	223	13	manchon	manchon	PROPN
dti-1325	223	14	,	,	PUNCT
dti-1325	223	15	c.	c.	PROPN
dti-1325	223	16	,	,	PUNCT
dti-1325	223	17	ferrer	ferrer	PROPN
dti-1325	223	18	,	,	PUNCT
dti-1325	223	19	m.	m.	NOUN
dti-1325	223	20	,	,	PUNCT
dti-1325	223	21	larrucea	larrucea	PROPN
dti-1325	223	22	,	,	PUNCT
dti-1325	223	23	s.	s.	PROPN
dti-1325	223	24	,	,	PUNCT
dti-1325	223	25	ayuso	ayuso	PROPN
dti-1325	223	26	,	,	PUNCT
dti-1325	223	27	m.s	m.s	PROPN
dti-1325	223	28	.	.	PROPN
dti-1325	223	29	and	and	CCONJ
dti-1325	223	30	parrilla	parrilla	PROPN
dti-1325	223	31	,	,	PUNCT
dti-1325	223	32	r.	r.	PROPN
dti-1325	223	33	2003	2003	NUM
dti-1325	223	34	.	.	PUNCT
dti-1325	224	1	disruption	disruption	NOUN
dti-1325	224	2	of	of	ADP
dti-1325	224	3	the	the	DET
dti-1325	224	4	beta3	beta3	NOUN
dti-1325	224	5	663–687	663–687	NUM
dti-1325	224	6	disulfi	disulfi	PROPN
dti-1325	224	7	de	de	X
dti-1325	224	8	bridge	bridge	NOUN
dti-1325	224	9	confers	confer	NOUN
dti-1325	224	10	constitutive	constitutive	ADJ
dti-1325	224	11	activity	activity	NOUN
dti-1325	224	12	to	to	ADP
dti-1325	224	13	beta3	beta3	NOUN
dti-1325	224	14	integrins	integrin	NOUN
dti-1325	224	15	.	.	PUNCT
dti-1325	225	1	blood	blood	NOUN
dti-1325	225	2	,	,	PUNCT
dti-1325	225	3	102:2491–7	102:2491–7	NUM
dti-1325	225	4	.	.	PUNCT
dti-1325	226	1	charo	charo	PROPN
dti-1325	226	2	,	,	PUNCT
dti-1325	226	3	i.f	i.f	PROPN
dti-1325	226	4	.	.	PROPN
dti-1325	226	5	,	,	PUNCT
dti-1325	226	6	nannizzi	nannizzi	PROPN
dti-1325	226	7	,	,	PUNCT
dti-1325	226	8	l.	l.	PROPN
dti-1325	226	9	,	,	PUNCT
dti-1325	226	10	phillips	phillips	PROPN
dti-1325	226	11	,	,	PUNCT
dti-1325	226	12	d.r	d.r	PROPN
dti-1325	226	13	.	.	PROPN
dti-1325	226	14	,	,	PUNCT
dti-1325	226	15	hsu	hsu	PROPN
dti-1325	226	16	,	,	PUNCT
dti-1325	226	17	m.a	m.a	PROPN
dti-1325	226	18	.	.	PROPN
dti-1325	226	19	and	and	CCONJ
dti-1325	226	20	scarborough	scarborough	PROPN
dti-1325	226	21	,	,	PUNCT
dti-1325	226	22	r.m	r.m	PROPN
dti-1325	226	23	.	.	PROPN
dti-1325	226	24	1991	1991	NUM
dti-1325	226	25	.	.	PUNCT
dti-1325	227	1	inhibition	inhibition	NOUN
dti-1325	227	2	of	of	ADP
dti-1325	227	3	fi	fi	NOUN
dti-1325	227	4	brinogen	brinogen	NOUN
dti-1325	227	5	binding	bind	VERB
dti-1325	227	6	to	to	AUX
dti-1325	227	7	gp	gp	VERB
dti-1325	227	8	iib	iib	PROPN
dti-1325	227	9	-	-	PUNCT
dti-1325	227	10	iiia	iiia	VERB
dti-1325	227	11	by	by	ADP
dti-1325	227	12	a	a	DET
dti-1325	227	13	gp	gp	NOUN
dti-1325	227	14	iiia	iiia	AUX
dti-1325	227	15	peptide	peptide	NOUN
dti-1325	227	16	.	.	PUNCT
dti-1325	228	1	j.	j.	PROPN
dti-1325	228	2	biol	biol	PROPN
dti-1325	228	3	.	.	PUNCT
dti-1325	229	1	chem	chem	PROPN
dti-1325	229	2	.	.	PUNCT
dti-1325	229	3	,	,	PUNCT
dti-1325	230	1	266:1415–21	266:1415–21	PROPN
dti-1325	230	2	.	.	PUNCT
dti-1325	231	1	chiang	chiang	PROPN
dti-1325	231	2	,	,	PUNCT
dti-1325	231	3	t.m	t.m	PROPN
dti-1325	231	4	.	.	PROPN
dti-1325	231	5	,	,	PUNCT
dti-1325	231	6	beachey	beachey	NOUN
dti-1325	231	7	,	,	PUNCT
dti-1325	231	8	e.h	e.h	PROPN
dti-1325	231	9	.	.	PROPN
dti-1325	231	10	and	and	CCONJ
dti-1325	231	11	kang	kang	PROPN
dti-1325	231	12	,	,	PUNCT
dti-1325	231	13	a.h	a.h	PROPN
dti-1325	231	14	.	.	PROPN
dti-1325	231	15	1975	1975	NUM
dti-1325	231	16	.	.	PUNCT
dti-1325	232	1	interaction	interaction	NOUN
dti-1325	232	2	of	of	ADP
dti-1325	232	3	a	a	DET
dti-1325	232	4	chick	chick	NOUN
dti-1325	232	5	skin	skin	NOUN
dti-1325	232	6	collagen	collagen	NOUN
dti-1325	232	7	fragment	fragment	NOUN
dti-1325	232	8	(	(	PUNCT
dti-1325	232	9	α1	α1	PROPN
dti-1325	232	10	-	-	PUNCT
dti-1325	232	11	cb5	cb5	NOUN
dti-1325	232	12	)	)	PUNCT
dti-1325	232	13	with	with	ADP
dti-1325	232	14	human	human	ADJ
dti-1325	232	15	platelets	platelet	NOUN
dti-1325	232	16	.	.	PUNCT
dti-1325	233	1	biochemical	biochemical	ADJ
dti-1325	233	2	studies	study	NOUN
dti-1325	233	3	during	during	ADP
dti-1325	233	4	the	the	DET
dti-1325	233	5	aggregation	aggregation	NOUN
dti-1325	233	6	and	and	CCONJ
dti-1325	233	7	release	release	NOUN
dti-1325	233	8	reaction	reaction	NOUN
dti-1325	233	9	.	.	PUNCT
dti-1325	234	1	j.	j.	PROPN
dti-1325	234	2	biol	biol	PROPN
dti-1325	234	3	.	.	PUNCT
dti-1325	235	1	chem	chem	PROPN
dti-1325	235	2	.	.	PUNCT
dti-1325	235	3	,	,	PUNCT
dti-1325	236	1	250:6916–24	250:6916–24	PROPN
dti-1325	236	2	.	.	PUNCT
dti-1325	237	1	chiang	chiang	PROPN
dti-1325	237	2	,	,	PUNCT
dti-1325	237	3	t.m	t.m	PROPN
dti-1325	237	4	.	.	PROPN
dti-1325	237	5	,	,	PUNCT
dti-1325	237	6	jin	jin	PROPN
dti-1325	237	7	,	,	PUNCT
dti-1325	237	8	a.	a.	NOUN
dti-1325	237	9	,	,	PUNCT
dti-1325	237	10	hasty	hasty	PROPN
dti-1325	237	11	,	,	PUNCT
dti-1325	237	12	k.	k.	PROPN
dti-1325	237	13	and	and	CCONJ
dti-1325	237	14	kang	kang	PROPN
dti-1325	237	15	,	,	PUNCT
dti-1325	237	16	a.h	a.h	PROPN
dti-1325	237	17	.	.	PROPN
dti-1325	237	18	1989	1989	NUM
dti-1325	237	19	.	.	PUNCT
dti-1325	238	1	collagen	collagen	NOUN
dti-1325	238	2	-	-	PUNCT
dti-1325	238	3	platelet	platelet	NOUN
dti-1325	238	4	interaction	interaction	NOUN
dti-1325	238	5	:	:	PUNCT
dti-1325	238	6	inhibition	inhibition	NOUN
dti-1325	238	7	by	by	ADP
dti-1325	238	8	a	a	DET
dti-1325	238	9	monoclonal	monoclonal	NOUN
dti-1325	238	10	antibody	antibody	NOUN
dti-1325	238	11	,	,	PUNCT
dti-1325	238	12	which	which	PRON
dti-1325	238	13	binds	bind	VERB
dti-1325	238	14	a	a	DET
dti-1325	238	15	90000	90000	NUM
dti-1325	238	16	dalton	dalton	PROPN
dti-1325	238	17	platelet	platelet	NOUN
dti-1325	238	18	glycoprotein	glycoprotein	NOUN
dti-1325	238	19	.	.	PUNCT
dti-1325	239	1	thromb	thromb	NOUN
dti-1325	239	2	.	.	PUNCT
dti-1325	240	1	res	re	NOUN
dti-1325	240	2	.	.	PROPN
dti-1325	240	3	,	,	PUNCT
dti-1325	240	4	53:129–43	53:129–43	PROPN
dti-1325	240	5	.	.	PUNCT
dti-1325	241	1	chiang	chiang	PROPN
dti-1325	241	2	,	,	PUNCT
dti-1325	241	3	t.m	t.m	PROPN
dti-1325	241	4	.	.	PROPN
dti-1325	241	5	and	and	CCONJ
dti-1325	241	6	zhu	zhu	PROPN
dti-1325	241	7	,	,	PUNCT
dti-1325	241	8	j.	j.	PROPN
dti-1325	241	9	2005	2005	NUM
dti-1325	241	10	.	.	PUNCT
dti-1325	242	1	a	a	DET
dti-1325	242	2	defi	defi	NOUN
dti-1325	242	3	ned	ned	NOUN
dti-1325	242	4	peptide	peptide	NOUN
dti-1325	242	5	that	that	PRON
dti-1325	242	6	inhibits	inhibit	VERB
dti-1325	242	7	the	the	DET
dti-1325	242	8	formation	formation	NOUN
dti-1325	242	9	of	of	ADP
dti-1325	242	10	the	the	DET
dti-1325	242	11	glycoprotein	glycoprotein	NOUN
dti-1325	242	12	iib	iib	NOUN
dti-1325	242	13	and	and	CCONJ
dti-1325	242	14	iiia	iiia	VERB
dti-1325	242	15	complex	complex	PROPN
dti-1325	242	16	.	.	PUNCT
dti-1325	243	1	thromb	thromb	PROPN
dti-1325	243	2	.	.	PUNCT
dti-1325	244	1	res	re	NOUN
dti-1325	244	2	.	.	PROPN
dti-1325	244	3	,	,	PUNCT
dti-1325	244	4	115:503–8	115:503–8	NUM
dti-1325	244	5	.	.	PUNCT
dti-1325	245	1	cheng	cheng	PROPN
dti-1325	245	2	,	,	PUNCT
dti-1325	245	3	j.	j.	PROPN
dti-1325	245	4	,	,	PUNCT
dti-1325	245	5	saigo	saigo	PROPN
dti-1325	245	6	,	,	PUNCT
dti-1325	245	7	h.	h.	PROPN
dti-1325	245	8	and	and	CCONJ
dti-1325	245	9	baldi	baldi	PROPN
dti-1325	245	10	,	,	PUNCT
dti-1325	245	11	p.	p.	NOUN
dti-1325	245	12	2006	2006	NUM
dti-1325	245	13	.	.	PUNCT
dti-1325	246	1	large	large	ADJ
dti-1325	246	2	-	-	PUNCT
dti-1325	246	3	scale	scale	NOUN
dti-1325	246	4	prediction	prediction	NOUN
dti-1325	246	5	of	of	ADP
dti-1325	246	6	disulphide	disulphide	ADJ
dti-1325	246	7	bridges	bridge	NOUN
dti-1325	246	8	using	use	VERB
dti-1325	246	9	kernel	kernel	PROPN
dti-1325	246	10	methods	method	NOUN
dti-1325	246	11	,	,	PUNCT
dti-1325	246	12	two	two	NUM
dti-1325	246	13	-	-	PUNCT
dti-1325	246	14	dimensional	dimensional	ADJ
dti-1325	246	15	recursive	recursive	ADJ
dti-1325	246	16	neural	neural	ADJ
dti-1325	246	17	networks	network	NOUN
dti-1325	246	18	,	,	PUNCT
dti-1325	246	19	and	and	CCONJ
dti-1325	246	20	weighted	weight	VERB
dti-1325	246	21	graph	graph	NOUN
dti-1325	246	22	matching	matching	NOUN
dti-1325	246	23	.	.	PUNCT
dti-1325	247	1	proteins	protein	NOUN
dti-1325	247	2	,	,	PUNCT
dti-1325	247	3	62:617–29	62:617–29	NOUN
dti-1325	247	4	.	.	PUNCT
dti-1325	248	1	d’souza	d’souza	PROPN
dti-1325	248	2	,	,	PUNCT
dti-1325	248	3	s.e	s.e	PROPN
dti-1325	248	4	.	.	PROPN
dti-1325	248	5	,	,	PUNCT
dti-1325	248	6	ginsberg	ginsberg	PROPN
dti-1325	248	7	,	,	PUNCT
dti-1325	248	8	m.e	m.e	PROPN
dti-1325	248	9	.	.	PROPN
dti-1325	248	10	,	,	PUNCT
dti-1325	248	11	matsueda	matsueda	PROPN
dti-1325	248	12	,	,	PUNCT
dti-1325	248	13	g.r	g.r	PROPN
dti-1325	248	14	.	.	PROPN
dti-1325	248	15	and	and	CCONJ
dti-1325	248	16	plow	plow	PROPN
dti-1325	248	17	,	,	PUNCT
dti-1325	248	18	e.f	e.f	PROPN
dti-1325	248	19	.	.	PROPN
dti-1325	248	20	1991	1991	NUM
dti-1325	248	21	.	.	PUNCT
dti-1325	249	1	a	a	DET
dti-1325	249	2	discrete	discrete	ADJ
dti-1325	249	3	sequence	sequence	NOUN
dti-1325	249	4	in	in	ADP
dti-1325	249	5	a	a	DET
dti-1325	249	6	platelet	platelet	NOUN
dti-1325	249	7	integrin	integrin	NOUN
dti-1325	249	8	is	be	AUX
dti-1325	249	9	involved	involve	VERB
dti-1325	249	10	in	in	ADP
dti-1325	249	11	ligand	ligand	ADJ
dti-1325	249	12	recognition	recognition	NOUN
dti-1325	249	13	.	.	PUNCT
dti-1325	250	1	nature	nature	NOUN
dti-1325	250	2	,	,	PUNCT
dti-1325	250	3	350:66–8	350:66–8	NUM
dti-1325	250	4	.	.	PUNCT
dti-1325	251	1	d’souza	d’souza	PROPN
dti-1325	251	2	,	,	PUNCT
dti-1325	251	3	s.e	s.e	PROPN
dti-1325	251	4	.	.	PROPN
dti-1325	251	5	,	,	PUNCT
dti-1325	251	6	haas	haas	PROPN
dti-1325	251	7	,	,	PUNCT
dti-1325	251	8	t.a	t.a	PROPN
dti-1325	251	9	.	.	PROPN
dti-1325	251	10	,	,	PUNCT
dti-1325	251	11	piotrowicz	piotrowicz	PROPN
dti-1325	251	12	,	,	PUNCT
dti-1325	251	13	r.s	r.s	PROPN
dti-1325	251	14	.	.	PROPN
dti-1325	251	15	,	,	PUNCT
dti-1325	251	16	byers	byer	NOUN
dti-1325	251	17	-	-	PUNCT
dti-1325	251	18	ward	ward	NOUN
dti-1325	251	19	,	,	PUNCT
dti-1325	251	20	v.	v.	PROPN
dti-1325	251	21	,	,	PUNCT
dti-1325	251	22	mcgrath	mcgrath	PROPN
dti-1325	251	23	,	,	PUNCT
dti-1325	251	24	d.e	d.e	PROPN
dti-1325	251	25	.	.	PROPN
dti-1325	251	26	,	,	PUNCT
dti-1325	251	27	soule	soule	PROPN
dti-1325	251	28	,	,	PUNCT
dti-1325	251	29	r.d	r.d	PROPN
dti-1325	251	30	.	.	PROPN
dti-1325	251	31	,	,	PUNCT
dti-1325	251	32	cierniewski	cierniewski	PROPN
dti-1325	251	33	,	,	PUNCT
dti-1325	251	34	c.	c.	PROPN
dti-1325	251	35	,	,	PUNCT
dti-1325	251	36	plow	plow	NOUN
dti-1325	251	37	,	,	PUNCT
dti-1325	251	38	e.f	e.f	PROPN
dti-1325	251	39	.	.	PROPN
dti-1325	251	40	and	and	CCONJ
dti-1325	251	41	smith	smith	PROPN
dti-1325	251	42	,	,	PUNCT
dti-1325	251	43	j.w	j.w	PROPN
dti-1325	251	44	.	.	PROPN
dti-1325	251	45	1994	1994	NUM
dti-1325	251	46	.	.	PUNCT
dti-1325	252	1	ligand	ligand	PROPN
dti-1325	252	2	and	and	CCONJ
dti-1325	252	3	cation	cation	NOUN
dti-1325	252	4	binding	bind	VERB
dti-1325	252	5	are	be	AUX
dti-1325	252	6	dual	dual	ADJ
dti-1325	252	7	functions	function	NOUN
dti-1325	252	8	of	of	ADP
dti-1325	252	9	a	a	DET
dti-1325	252	10	discrete	discrete	ADJ
dti-1325	252	11	segment	segment	NOUN
dti-1325	252	12	of	of	ADP
dti-1325	252	13	the	the	DET
dti-1325	252	14	integrin	integrin	NOUN
dti-1325	252	15	beta	beta	NOUN
dti-1325	252	16	3	3	NUM
dti-1325	252	17	subunit	subunit	NOUN
dti-1325	252	18	:	:	PUNCT
dti-1325	252	19	cation	cation	NOUN
dti-1325	252	20	displacement	displacement	NOUN
dti-1325	252	21	is	be	AUX
dti-1325	252	22	involved	involve	VERB
dti-1325	252	23	in	in	ADP
dti-1325	252	24	ligand	ligand	ADJ
dti-1325	252	25	binding	binding	NOUN
dti-1325	252	26	.	.	PUNCT
dti-1325	253	1	cell	cell	NOUN
dti-1325	253	2	,	,	PUNCT
dti-1325	253	3	79:659–67	79:659–67	NUM
dti-1325	253	4	.	.	PUNCT
dti-1325	254	1	du	du	PROPN
dti-1325	254	2	,	,	PUNCT
dti-1325	254	3	x.p	x.p	PROPN
dti-1325	254	4	.	.	PROPN
dti-1325	254	5	,	,	PUNCT
dti-1325	254	6	plow	plow	NOUN
dti-1325	254	7	,	,	PUNCT
dti-1325	254	8	e.f	e.f	PROPN
dti-1325	254	9	.	.	PROPN
dti-1325	254	10	,	,	PUNCT
dti-1325	254	11	frelinger	frelinger	ADV
dti-1325	254	12	,	,	PUNCT
dti-1325	254	13	a.l	a.l	PROPN
dti-1325	254	14	.	.	PROPN
dti-1325	254	15	,	,	PUNCT
dti-1325	254	16	o’toole	o’toole	PROPN
dti-1325	254	17	,	,	PUNCT
dti-1325	254	18	t.e	t.e	PROPN
dti-1325	254	19	.	.	PROPN
dti-1325	254	20	,	,	PUNCT
dti-1325	254	21	loftus	loftus	PROPN
dti-1325	254	22	,	,	PUNCT
dti-1325	254	23	j.c	j.c	PROPN
dti-1325	254	24	.	.	PROPN
dti-1325	254	25	and	and	CCONJ
dti-1325	254	26	ginsberg	ginsberg	PROPN
dti-1325	254	27	,	,	PUNCT
dti-1325	254	28	m.h	m.h	PROPN
dti-1325	254	29	.	.	PROPN
dti-1325	254	30	1991	1991	NUM
dti-1325	254	31	.	.	PUNCT
dti-1325	255	1	ligands	ligand	NOUN
dti-1325	255	2	“	"	PUNCT
dti-1325	255	3	activate	activate	VERB
dti-1325	255	4	”	"	PUNCT
dti-1325	255	5	integrin	integrin	NOUN
dti-1325	255	6	alpha	alpha	NOUN
dti-1325	255	7	iib	iib	PROPN
dti-1325	255	8	beta	beta	PROPN
dti-1325	255	9	3	3	NUM
dti-1325	255	10	(	(	PUNCT
dti-1325	255	11	platelet	platelet	NOUN
dti-1325	255	12	gpiib	gpiib	NOUN
dti-1325	255	13	-	-	PUNCT
dti-1325	255	14	iiia	iiia	NOUN
dti-1325	255	15	)	)	PUNCT
dti-1325	255	16	.	.	PUNCT
dti-1325	256	1	cell	cell	NOUN
dti-1325	256	2	,	,	PUNCT
dti-1325	256	3	65:409–16	65:409–16	NOUN
dti-1325	256	4	.	.	PUNCT
dti-1325	257	1	feuston	feuston	PROPN
dti-1325	257	2	,	,	PUNCT
dti-1325	257	3	b.p	b.p	PROPN
dti-1325	257	4	.	.	PROPN
dti-1325	257	5	2003	2003	NUM
dti-1325	257	6	.	.	PUNCT
dti-1325	258	1	molecular	molecular	ADJ
dti-1325	258	2	model	model	NOUN
dti-1325	258	3	of	of	ADP
dti-1325	258	4	the	the	DET
dti-1325	258	5	alpha(iib)beta(3	alpha(iib)beta(3	PROPN
dti-1325	258	6	)	)	PUNCT
dti-1325	258	7	integrin	integrin	NOUN
dti-1325	258	8	.	.	PUNCT
dti-1325	259	1	j.	j.	PROPN
dti-1325	259	2	med	med	PROPN
dti-1325	259	3	.	.	PROPN
dti-1325	259	4	chem	chem	PROPN
dti-1325	259	5	.	.	PUNCT
dti-1325	259	6	,	,	PUNCT
dti-1325	259	7	46:5316–25	46:5316–25	X
dti-1325	259	8	.	.	PUNCT
dti-1325	260	1	filizola	filizola	PROPN
dti-1325	260	2	,	,	PUNCT
dti-1325	260	3	m.	m.	NOUN
dti-1325	260	4	,	,	PUNCT
dti-1325	260	5	hassan	hassan	PROPN
dti-1325	260	6	,	,	PUNCT
dti-1325	260	7	s.a	s.a	PROPN
dti-1325	260	8	.	.	PROPN
dti-1325	260	9	,	,	PUNCT
dti-1325	260	10	artoni	artoni	PROPN
dti-1325	260	11	,	,	PUNCT
dti-1325	260	12	a.	a.	NOUN
dti-1325	260	13	,	,	PUNCT
dti-1325	260	14	coller	coller	PROPN
dti-1325	260	15	,	,	PUNCT
dti-1325	260	16	b.a	b.a	PROPN
dti-1325	260	17	.	.	PROPN
dti-1325	260	18	and	and	CCONJ
dti-1325	260	19	weinstein	weinstein	PROPN
dti-1325	260	20	,	,	PUNCT
dti-1325	260	21	s.	s.	PROPN
dti-1325	260	22	2004	2004	NUM
dti-1325	260	23	.	.	PUNCT
dti-1325	261	1	mechanistic	mechanistic	ADJ
dti-1325	261	2	insights	insight	NOUN
dti-1325	261	3	from	from	ADP
dti-1325	261	4	a	a	DET
dti-1325	261	5	refi	refi	NOUN
dti-1325	261	6	ned	ne	VERB
dti-1325	261	7	three	three	NUM
dti-1325	261	8	-	-	PUNCT
dti-1325	261	9	dimensional	dimensional	ADJ
dti-1325	261	10	model	model	NOUN
dti-1325	261	11	of	of	ADP
dti-1325	261	12	integrin	integrin	PROPN
dti-1325	261	13	alphaiibbeta3	alphaiibbeta3	PROPN
dti-1325	261	14	.	.	PUNCT
dti-1325	262	1	j.	j.	PROPN
dti-1325	262	2	biol	biol	PROPN
dti-1325	262	3	.	.	PUNCT
dti-1325	263	1	chem	chem	PROPN
dti-1325	263	2	.	.	PUNCT
dti-1325	263	3	,	,	PUNCT
dti-1325	263	4	279:24624–30	279:24624–30	PROPN
dti-1325	263	5	.	.	PUNCT
dti-1325	264	1	grinnell	grinnell	PROPN
dti-1325	264	2	,	,	PUNCT
dti-1325	264	3	f.	f.	PROPN
dti-1325	264	4	1980	1980	NUM
dti-1325	264	5	.	.	PUNCT
dti-1325	265	1	fibroblast	fibroblast	ADJ
dti-1325	265	2	receptor	receptor	NOUN
dti-1325	265	3	for	for	ADP
dti-1325	265	4	cell	cell	NOUN
dti-1325	265	5	-	-	PUNCT
dti-1325	265	6	substratum	substratum	NOUN
dti-1325	265	7	adhesion	adhesion	NOUN
dti-1325	265	8	:	:	PUNCT
dti-1325	265	9	studies	study	NOUN
dti-1325	265	10	on	on	ADP
dti-1325	265	11	the	the	DET
dti-1325	265	12	interaction	interaction	NOUN
dti-1325	265	13	of	of	ADP
dti-1325	265	14	baby	baby	NOUN
dti-1325	265	15	hamster	hamster	PROPN
dti-1325	265	16	kidney	kidney	NOUN
dti-1325	265	17	cells	cell	NOUN
dti-1325	265	18	with	with	ADP
dti-1325	265	19	latex	latex	NOUN
dti-1325	265	20	beads	bead	NOUN
dti-1325	265	21	coated	coat	VERB
dti-1325	265	22	by	by	ADP
dti-1325	265	23	cold	cold	ADJ
dti-1325	265	24	insoluble	insoluble	ADJ
dti-1325	265	25	globulin	globulin	NOUN
dti-1325	265	26	(	(	PUNCT
dti-1325	265	27	plasma	plasma	NOUN
dti-1325	265	28	fibronectin	fibronectin	NOUN
dti-1325	265	29	)	)	PUNCT
dti-1325	265	30	.	.	PUNCT
dti-1325	266	1	j.	j.	PROPN
dti-1325	266	2	cell	cell	PROPN
dti-1325	266	3	biol	biol	PROPN
dti-1325	266	4	.	.	PUNCT
dti-1325	266	5	,	,	PUNCT
dti-1325	266	6	86:104–12	86:104–12	PROPN
dti-1325	266	7	.	.	PUNCT
dti-1325	267	1	kamata	kamata	PROPN
dti-1325	267	2	,	,	PUNCT
dti-1325	267	3	t.	t.	PROPN
dti-1325	267	4	,	,	PUNCT
dti-1325	267	5	tieu	tieu	PROPN
dti-1325	267	6	,	,	PUNCT
dti-1325	267	7	k.k	k.k	PROPN
dti-1325	267	8	.	.	PROPN
dti-1325	267	9	,	,	PUNCT
dti-1325	267	10	irie	irie	PROPN
dti-1325	267	11	,	,	PUNCT
dti-1325	267	12	a.	a.	NOUN
dti-1325	267	13	and	and	CCONJ
dti-1325	267	14	springer	springer	NOUN
dti-1325	267	15	,	,	PUNCT
dti-1325	267	16	t.a	t.a	PROPN
dti-1325	267	17	.	.	PROPN
dti-1325	267	18	2001	2001	NUM
dti-1325	267	19	.	.	PUNCT
dti-1325	268	1	amino	amino	NOUN
dti-1325	268	2	acid	acid	NOUN
dti-1325	268	3	residues	residue	NOUN
dti-1325	268	4	in	in	ADP
dti-1325	268	5	the	the	DET
dti-1325	268	6	alpha	alpha	NOUN
dti-1325	268	7	iib	iib	NOUN
dti-1325	268	8	subunit	subunit	NOUN
dti-1325	268	9	that	that	PRON
dti-1325	268	10	are	be	AUX
dti-1325	268	11	critical	critical	ADJ
dti-1325	268	12	for	for	ADP
dti-1325	268	13	ligand	ligand	NOUN
dti-1325	268	14	binding	bind	VERB
dti-1325	268	15	to	to	ADP
dti-1325	268	16	integrin	integrin	PROPN
dti-1325	268	17	alphaiibbeta3	alphaiibbeta3	NOUN
dti-1325	268	18	are	be	AUX
dti-1325	268	19	clustered	cluster	VERB
dti-1325	268	20	in	in	ADP
dti-1325	268	21	the	the	DET
dti-1325	268	22	beta	beta	NOUN
dti-1325	268	23	-	-	PUNCT
dti-1325	268	24	propeller	propeller	NOUN
dti-1325	268	25	model	model	NOUN
dti-1325	268	26	.	.	PUNCT
dti-1325	269	1	j.	j.	PROPN
dti-1325	269	2	biol	biol	PROPN
dti-1325	269	3	.	.	PUNCT
dti-1325	270	1	chem	chem	PROPN
dti-1325	270	2	.	.	PUNCT
dti-1325	270	3	,	,	PUNCT
dti-1325	271	1	276:44275–83	276:44275–83	NUM
dti-1325	271	2	.	.	PUNCT
dti-1325	271	3	kashiwagi	kashiwagi	PROPN
dti-1325	271	4	,	,	PUNCT
dti-1325	271	5	h.	h.	PROPN
dti-1325	271	6	,	,	PUNCT
dti-1325	271	7	tomiyama	tomiyama	PROPN
dti-1325	271	8	,	,	PUNCT
dti-1325	271	9	y.	y.	PROPN
dti-1325	271	10	,	,	PUNCT
dti-1325	271	11	tadokoro	tadokoro	NUM
dti-1325	271	12	,	,	PUNCT
dti-1325	271	13	s.	s.	PROPN
dti-1325	271	14	,	,	PUNCT
dti-1325	271	15	honda	honda	PROPN
dti-1325	271	16	,	,	PUNCT
dti-1325	271	17	s.	s.	PROPN
dti-1325	271	18	,	,	PUNCT
dti-1325	271	19	shiraga	shiraga	NOUN
dti-1325	271	20	,	,	PUNCT
dti-1325	271	21	m.	m.	NOUN
dti-1325	271	22	,	,	PUNCT
dti-1325	271	23	mizutani	mizutani	PROPN
dti-1325	271	24	,	,	PUNCT
dti-1325	271	25	h.	h.	PROPN
dti-1325	271	26	,	,	PUNCT
dti-1325	271	27	handa	handa	PROPN
dti-1325	271	28	,	,	PUNCT
dti-1325	271	29	m.	m.	NOUN
dti-1325	271	30	,	,	PUNCT
dti-1325	271	31	kurata	kurata	NOUN
dti-1325	271	32	,	,	PUNCT
dti-1325	271	33	y.	y.	PROPN
dti-1325	271	34	,	,	PUNCT
dti-1325	271	35	matsuzaw	matsuzaw	PROPN
dti-1325	271	36	,	,	PUNCT
dti-1325	271	37	y.	y.	PROPN
dti-1325	271	38	and	and	CCONJ
dti-1325	271	39	shattil	shattil	PROPN
dti-1325	271	40	,	,	PUNCT
dti-1325	271	41	s.j	s.j	PROPN
dti-1325	271	42	.	.	PROPN
dti-1325	271	43	1999	1999	NUM
dti-1325	271	44	.	.	PUNCT
dti-1325	272	1	a	a	DET
dti-1325	272	2	mutation	mutation	NOUN
dti-1325	272	3	in	in	ADP
dti-1325	272	4	the	the	DET
dti-1325	272	5	extracellular	extracellular	ADJ
dti-1325	272	6	cysteine	cysteine	NOUN
dti-1325	272	7	-	-	PUNCT
dti-1325	272	8	rich	rich	ADJ
dti-1325	272	9	repeats	repeat	NOUN
dti-1325	272	10	region	region	NOUN
dti-1325	272	11	of	of	ADP
dti-1325	272	12	the	the	DET
dti-1325	272	13	beta3	beta3	NOUN
dti-1325	272	14	subunit	subunit	NOUN
dti-1325	272	15	activates	activate	VERB
dti-1325	272	16	integrins	integrin	VERB
dti-1325	272	17	alphaiibbeta3	alphaiibbeta3	NOUN
dti-1325	272	18	and	and	CCONJ
dti-1325	272	19	alphavbeta3	alphavbeta3	PROPN
dti-1325	272	20	.	.	PUNCT
dti-1325	273	1	blood	blood	NOUN
dti-1325	273	2	,	,	PUNCT
dti-1325	273	3	93:2559–68	93:2559–68	NUM
dti-1325	273	4	.	.	PUNCT
dti-1325	274	1	litvinov	litvinov	PROPN
dti-1325	274	2	,	,	PUNCT
dti-1325	274	3	r.i	r.i	PROPN
dti-1325	274	4	.	.	PROPN
dti-1325	274	5	,	,	PUNCT
dti-1325	274	6	nagaswami	nagaswami	PROPN
dti-1325	274	7	,	,	PUNCT
dti-1325	274	8	c.	c.	PROPN
dti-1325	274	9	,	,	PUNCT
dti-1325	274	10	vilaire	vilaire	ADJ
dti-1325	274	11	,	,	PUNCT
dti-1325	274	12	g.	g.	PROPN
dti-1325	274	13	,	,	PUNCT
dti-1325	274	14	shuman	shuman	PROPN
dti-1325	274	15	,	,	PUNCT
dti-1325	274	16	h.	h.	PROPN
dti-1325	274	17	,	,	PUNCT
dti-1325	274	18	bennett	bennett	PROPN
dti-1325	274	19	,	,	PUNCT
dti-1325	274	20	j.s	j.s	PROPN
dti-1325	274	21	.	.	PROPN
dti-1325	274	22	and	and	CCONJ
dti-1325	274	23	weisel	weisel	PROPN
dti-1325	274	24	,	,	PUNCT
dti-1325	274	25	j.w	j.w	PROPN
dti-1325	274	26	.	.	PROPN
dti-1325	274	27	2004	2004	NUM
dti-1325	274	28	.	.	PUNCT
dti-1325	275	1	functional	functional	ADJ
dti-1325	275	2	and	and	CCONJ
dti-1325	275	3	structural	structural	ADJ
dti-1325	275	4	correlations	correlation	NOUN
dti-1325	275	5	of	of	ADP
dti-1325	275	6	individual	individual	ADJ
dti-1325	275	7	alphaiibbeta3	alphaiibbeta3	NOUN
dti-1325	275	8	molecules	molecule	NOUN
dti-1325	275	9	.	.	PUNCT
dti-1325	276	1	blood	blood	NOUN
dti-1325	276	2	,	,	PUNCT
dti-1325	276	3	104:3979–85	104:3979–85	PROPN
dti-1325	276	4	.	.	PUNCT
dti-1325	277	1	luo	luo	PROPN
dti-1325	277	2	,	,	PUNCT
dti-1325	277	3	b.h	b.h	PROPN
dti-1325	277	4	.	.	PROPN
dti-1325	277	5	,	,	PUNCT
dti-1325	277	6	takagi	takagi	PROPN
dti-1325	277	7	,	,	PUNCT
dti-1325	277	8	j.	j.	PROPN
dti-1325	277	9	and	and	CCONJ
dti-1325	277	10	springer	springer	PROPN
dti-1325	277	11	,	,	PUNCT
dti-1325	277	12	t.a	t.a	PROPN
dti-1325	277	13	.	.	PROPN
dti-1325	277	14	2004	2004	NUM
dti-1325	277	15	.	.	PUNCT
dti-1325	278	1	locking	lock	VERB
dti-1325	278	2	the	the	DET
dti-1325	278	3	beta3	beta3	PROPN
dti-1325	278	4	integrin	integrin	NOUN
dti-1325	278	5	i	i	NOUN
dti-1325	278	6	-	-	PUNCT
dti-1325	278	7	like	like	ADJ
dti-1325	278	8	domain	domain	NOUN
dti-1325	278	9	into	into	ADP
dti-1325	278	10	high	high	ADJ
dti-1325	278	11	and	and	CCONJ
dti-1325	278	12	low	low	ADJ
dti-1325	278	13	affi	affi	PROPN
dti-1325	278	14	nity	nity	NOUN
dti-1325	278	15	conformations	conformation	NOUN
dti-1325	278	16	with	with	ADP
dti-1325	278	17	disulfi	disulfi	PROPN
dti-1325	278	18	des	des	PROPN
dti-1325	278	19	.	.	PROPN
dti-1325	278	20	j.	j.	PROPN
dti-1325	278	21	biol	biol	PROPN
dti-1325	278	22	.	.	PUNCT
dti-1325	279	1	chem	chem	PROPN
dti-1325	279	2	.	.	PUNCT
dti-1325	279	3	,	,	PUNCT
dti-1325	280	1	279:10215–21	279:10215–21	X
dti-1325	280	2	.	.	PUNCT
dti-1325	280	3	parise	parise	PROPN
dti-1325	280	4	,	,	PUNCT
dti-1325	280	5	l.v	l.v	PROPN
dti-1325	280	6	.	.	PROPN
dti-1325	280	7	,	,	PUNCT
dti-1325	280	8	helgerson	helgerson	PROPN
dti-1325	280	9	,	,	PUNCT
dti-1325	280	10	s.l	s.l	PROPN
dti-1325	280	11	.	.	PROPN
dti-1325	280	12	,	,	PUNCT
dti-1325	280	13	steiner	steiner	PROPN
dti-1325	280	14	,	,	PUNCT
dti-1325	280	15	b.	b.	PROPN
dti-1325	280	16	and	and	CCONJ
dti-1325	280	17	phillips	phillips	PROPN
dti-1325	280	18	,	,	PUNCT
dti-1325	280	19	d.r	d.r	PROPN
dti-1325	280	20	.	.	PROPN
dti-1325	280	21	1987	1987	NUM
dti-1325	280	22	.	.	PUNCT
dti-1325	281	1	synthetic	synthetic	ADJ
dti-1325	281	2	peptides	peptide	NOUN
dti-1325	281	3	derived	derive	VERB
dti-1325	281	4	from	from	ADP
dti-1325	281	5	fi	fi	NOUN
dti-1325	281	6	brinogen	brinogen	NOUN
dti-1325	281	7	and	and	CCONJ
dti-1325	281	8	fi	fi	NOUN
dti-1325	281	9	bronectin	bronectin	PROPN
dti-1325	281	10	change	change	VERB
dti-1325	281	11	the	the	DET
dti-1325	281	12	conformation	conformation	NOUN
dti-1325	281	13	of	of	ADP
dti-1325	281	14	purifi	purifi	ADJ
dti-1325	281	15	ed	ed	PROPN
dti-1325	281	16	platelet	platelet	NOUN
dti-1325	281	17	glycoprotein	glycoprotein	NOUN
dti-1325	281	18	iib	iib	NOUN
dti-1325	281	19	-	-	PUNCT
dti-1325	281	20	iiia	iiia	PROPN
dti-1325	281	21	.	.	PUNCT
dti-1325	282	1	j.	j.	PROPN
dti-1325	282	2	biol	biol	PROPN
dti-1325	282	3	.	.	PUNCT
dti-1325	283	1	chem	chem	PROPN
dti-1325	283	2	.	.	PUNCT
dti-1325	283	3	,	,	PUNCT
dti-1325	283	4	262:12597–602	262:12597–602	PROPN
dti-1325	283	5	.	.	PUNCT
dti-1325	284	1	rice	rice	PROPN
dti-1325	284	2	,	,	PUNCT
dti-1325	284	3	r.h	r.h	PROPN
dti-1325	284	4	.	.	PROPN
dti-1325	284	5	and	and	CCONJ
dti-1325	284	6	means	mean	NOUN
dti-1325	284	7	,	,	PUNCT
dti-1325	284	8	g.e	g.e	PROPN
dti-1325	284	9	.	.	PROPN
dti-1325	284	10	1971	1971	NUM
dti-1325	284	11	.	.	PUNCT
dti-1325	285	1	radioactive	radioactive	ADJ
dti-1325	285	2	labeling	labeling	NOUN
dti-1325	285	3	of	of	ADP
dti-1325	285	4	proteins	protein	NOUN
dti-1325	285	5	in	in	ADP
dti-1325	285	6	vitro	vitro	X
dti-1325	285	7	.	.	PUNCT
dti-1325	286	1	j.	j.	PROPN
dti-1325	286	2	biol	biol	PROPN
dti-1325	286	3	.	.	PUNCT
dti-1325	287	1	chem	chem	PROPN
dti-1325	287	2	.	.	PUNCT
dti-1325	287	3	,	,	PUNCT
dti-1325	288	1	246:831–2	246:831–2	X
dti-1325	288	2	.	.	PUNCT
dti-1325	289	1	schwartz	schwartz	PROPN
dti-1325	289	2	,	,	PUNCT
dti-1325	289	3	m.a	m.a	PROPN
dti-1325	289	4	.	.	PROPN
dti-1325	289	5	,	,	PUNCT
dti-1325	289	6	schaller	schaller	PROPN
dti-1325	289	7	,	,	PUNCT
dti-1325	289	8	m.d	m.d	PROPN
dti-1325	289	9	.	.	PROPN
dti-1325	289	10	and	and	CCONJ
dti-1325	289	11	ginsberg	ginsberg	PROPN
dti-1325	289	12	,	,	PUNCT
dti-1325	289	13	m.h	m.h	PROPN
dti-1325	289	14	.	.	PROPN
dti-1325	289	15	1995	1995	NUM
dti-1325	289	16	.	.	PUNCT
dti-1325	290	1	integrins	integrin	VERB
dti-1325	290	2	:	:	PUNCT
dti-1325	290	3	emerging	emerge	VERB
dti-1325	290	4	paradigms	paradigm	NOUN
dti-1325	290	5	of	of	ADP
dti-1325	290	6	signal	signal	ADJ
dti-1325	290	7	transduction	transduction	NOUN
dti-1325	290	8	.	.	PUNCT
dti-1325	291	1	annu	annu	PROPN
dti-1325	291	2	rev	rev	VERB
dti-1325	291	3	.	.	PROPN
dti-1325	291	4	cell	cell	PROPN
dti-1325	291	5	dev	dev	PROPN
dti-1325	291	6	.	.	PUNCT
dti-1325	292	1	biol	biol	PROPN
dti-1325	292	2	.	.	PUNCT
dti-1325	292	3	,	,	PUNCT
dti-1325	292	4	11:549–99	11:549–99	PROPN
dti-1325	292	5	.	.	PUNCT
dti-1325	293	1	steiner	steiner	PROPN
dti-1325	293	2	,	,	PUNCT
dti-1325	293	3	b.	b.	PROPN
dti-1325	293	4	,	,	PUNCT
dti-1325	293	5	trzeciak	trzeciak	PROPN
dti-1325	293	6	,	,	PUNCT
dti-1325	293	7	a.	a.	NOUN
dti-1325	293	8	,	,	PUNCT
dti-1325	293	9	pfenninger	pfenninger	PROPN
dti-1325	293	10	,	,	PUNCT
dti-1325	293	11	g.	g.	PROPN
dti-1325	293	12	and	and	CCONJ
dti-1325	293	13	kouns	kouns	PROPN
dti-1325	293	14	,	,	PUNCT
dti-1325	293	15	w.c	w.c	PROPN
dti-1325	293	16	.	.	PROPN
dti-1325	293	17	1993	1993	NUM
dti-1325	293	18	.	.	PUNCT
dti-1325	294	1	peptides	peptide	NOUN
dti-1325	294	2	derived	derive	VERB
dti-1325	294	3	from	from	ADP
dti-1325	294	4	a	a	DET
dti-1325	294	5	sequence	sequence	NOUN
dti-1325	294	6	within	within	ADP
dti-1325	294	7	beta	beta	ADJ
dti-1325	294	8	3	3	NUM
dti-1325	294	9	integrin	integrin	NOUN
dti-1325	294	10	bind	bind	VERB
dti-1325	294	11	to	to	ADP
dti-1325	294	12	platelet	platelet	NOUN
dti-1325	294	13	al.phaiib	al.phaiib	ADV
dti-1325	294	14	beta3	beta3	NOUN
dti-1325	294	15	(	(	PUNCT
dti-1325	294	16	gpiib	gpiib	NOUN
dti-1325	294	17	-	-	PUNCT
dti-1325	294	18	iiia	iiia	NOUN
dti-1325	294	19	)	)	PUNCT
dti-1325	294	20	and	and	CCONJ
dti-1325	294	21	inhibit	inhibit	VERB
dti-1325	294	22	ligand	ligand	NOUN
dti-1325	294	23	binding	binding	NOUN
dti-1325	294	24	.	.	PUNCT
dti-1325	295	1	j.	j.	PROPN
dti-1325	295	2	biol	biol	PROPN
dti-1325	295	3	.	.	PUNCT
dti-1325	296	1	chem	chem	PROPN
dti-1325	296	2	.	.	PUNCT
dti-1325	296	3	,	,	PUNCT
dti-1325	297	1	268:6870–3	268:6870–3	NUM
dti-1325	297	2	.	.	PUNCT
dti-1325	298	1	sun	sun	PROPN
dti-1325	298	2	,	,	PUNCT
dti-1325	298	3	q.h	q.h	PROPN
dti-1325	298	4	.	.	PROPN
dti-1325	298	5	,	,	PUNCT
dti-1325	298	6	liu	liu	PROPN
dti-1325	298	7	,	,	PUNCT
dti-1325	298	8	c.y	c.y	PROPN
dti-1325	298	9	.	.	PROPN
dti-1325	298	10	,	,	PUNCT
dti-1325	298	11	wang	wang	PROPN
dti-1325	298	12	,	,	PUNCT
dti-1325	298	13	r.	r.	PROPN
dti-1325	298	14	,	,	PUNCT
dti-1325	298	15	paddock	paddock	NOUN
dti-1325	298	16	,	,	PUNCT
dti-1325	298	17	c.	c.	PROPN
dti-1325	298	18	and	and	CCONJ
dti-1325	298	19	newman	newman	PROPN
dti-1325	298	20	,	,	PUNCT
dti-1325	298	21	p.j	p.j	PROPN
dti-1325	298	22	.	.	PROPN
dti-1325	298	23	2002	2002	NUM
dti-1325	298	24	.	.	PUNCT
dti-1325	299	1	disruption	disruption	NOUN
dti-1325	299	2	of	of	ADP
dti-1325	299	3	the	the	DET
dti-1325	299	4	long	long	ADJ
dti-1325	299	5	-	-	PUNCT
dti-1325	299	6	range	range	NOUN
dti-1325	299	7	gpiiia	gpiiia	NOUN
dti-1325	299	8	cys(5)-cys(435	cys(5)-cys(435	PROPN
dti-1325	299	9	)	)	PUNCT
dti-1325	299	10	disulfi	disulfi	PROPN
dti-1325	299	11	de	de	X
dti-1325	299	12	bond	bond	NOUN
dti-1325	299	13	results	result	NOUN
dti-1325	299	14	in	in	ADP
dti-1325	299	15	the	the	DET
dti-1325	299	16	production	production	NOUN
dti-1325	299	17	of	of	ADP
dti-1325	299	18	constitutively	constitutively	ADV
dti-1325	299	19	active	active	ADJ
dti-1325	299	20	gpiib	gpiib	NOUN
dti-1325	299	21	-	-	PUNCT
dti-1325	299	22	iiia	iiia	NOUN
dti-1325	299	23	(	(	PUNCT
dti-1325	299	24	alpha(iib)beta(3	alpha(iib)beta(3	PROPN
dti-1325	299	25	)	)	PUNCT
dti-1325	299	26	)	)	PUNCT
dti-1325	299	27	integrin	integrin	NOUN
dti-1325	299	28	complexes	complex	NOUN
dti-1325	299	29	.	.	PUNCT
dti-1325	300	1	blood	blood	NOUN
dti-1325	300	2	,	,	PUNCT
dti-1325	300	3	100:2094–101	100:2094–101	NUM
dti-1325	300	4	.	.	PUNCT
dti-1325	301	1	takagi	takagi	PROPN
dti-1325	301	2	,	,	PUNCT
dti-1325	301	3	j.	j.	PROPN
dti-1325	301	4	,	,	PUNCT
dti-1325	301	5	petre	petre	PROPN
dti-1325	301	6	,	,	PUNCT
dti-1325	301	7	b.m	b.m	PROPN
dti-1325	301	8	.	.	PROPN
dti-1325	301	9	,	,	PUNCT
dti-1325	301	10	walz	walz	PROPN
dti-1325	301	11	,	,	PUNCT
dti-1325	301	12	t.	t.	NOUN
dti-1325	301	13	and	and	CCONJ
dti-1325	301	14	springer	springer	NOUN
dti-1325	301	15	,	,	PUNCT
dti-1325	301	16	t.a	t.a	PROPN
dti-1325	301	17	.	.	PROPN
dti-1325	301	18	2002	2002	NUM
dti-1325	301	19	.	.	PUNCT
dti-1325	302	1	global	global	ADJ
dti-1325	302	2	conformational	conformational	ADJ
dti-1325	302	3	rearrangements	rearrangement	NOUN
dti-1325	302	4	in	in	ADP
dti-1325	302	5	integrin	integrin	NOUN
dti-1325	302	6	extracellular	extracellular	ADJ
dti-1325	302	7	domains	domain	NOUN
dti-1325	302	8	in	in	ADP
dti-1325	302	9	outsidein	outsidein	PROPN
dti-1325	302	10	and	and	CCONJ
dti-1325	302	11	inside	inside	NOUN
dti-1325	302	12	-	-	PUNCT
dti-1325	302	13	out	out	ADP
dti-1325	302	14	signaling	signal	VERB
dti-1325	302	15	.	.	PUNCT
dti-1325	303	1	cell	cell	NOUN
dti-1325	303	2	,	,	PUNCT
dti-1325	303	3	110:599–611	110:599–611	NUM
dti-1325	303	4	.	.	PUNCT
dti-1325	304	1	76	76	NUM
dti-1325	304	2	woo	woo	NOUN
dti-1325	304	3	-	-	PUNCT
dti-1325	304	4	rasberry	rasberry	NOUN
dti-1325	304	5	and	and	CCONJ
dti-1325	304	6	chiang	chiang	PROPN
dti-1325	304	7	drug	drug	PROPN
dti-1325	304	8	target	target	NOUN
dti-1325	304	9	insights	insight	VERB
dti-1325	304	10	2008:3	2008:3	NUM
dti-1325	304	11	takagi	takagi	NOUN
dti-1325	304	12	,	,	PUNCT
dti-1325	304	13	j.	j.	PROPN
dti-1325	304	14	2004	2004	PROPN
dti-1325	304	15	.	.	PUNCT
dti-1325	305	1	structural	structural	ADJ
dti-1325	305	2	basis	basis	NOUN
dti-1325	305	3	for	for	ADP
dti-1325	305	4	ligand	ligand	ADJ
dti-1325	305	5	recognition	recognition	NOUN
dti-1325	305	6	by	by	ADP
dti-1325	305	7	rgd	rgd	PROPN
dti-1325	305	8	(	(	PUNCT
dti-1325	305	9	arg	arg	NOUN
dti-1325	305	10	-	-	PUNCT
dti-1325	305	11	gly	gly	ADJ
dti-1325	305	12	-	-	PUNCT
dti-1325	305	13	asp)dependent	asp)dependent	NOUN
dti-1325	305	14	integrins	integrin	VERB
dti-1325	305	15	.	.	PUNCT
dti-1325	306	1	biochem	biochem	PROPN
dti-1325	306	2	.	.	PUNCT
dti-1325	307	1	soc	soc	PROPN
dti-1325	307	2	.	.	PUNCT
dti-1325	308	1	trans	trans	PROPN
dti-1325	308	2	.	.	PROPN
dti-1325	308	3	,	,	PUNCT
dti-1325	308	4	32:403–6	32:403–6	NUM
dti-1325	308	5	.	.	PUNCT
dti-1325	309	1	wang	wang	PROPN
dti-1325	309	2	,	,	PUNCT
dti-1325	309	3	r.	r.	PROPN
dti-1325	309	4	,	,	PUNCT
dti-1325	309	5	peterson	peterson	PROPN
dti-1325	309	6	,	,	PUNCT
dti-1325	309	7	j.	j.	PROPN
dti-1325	309	8	,	,	PUNCT
dti-1325	309	9	aster	aster	NOUN
dti-1325	309	10	,	,	PUNCT
dti-1325	309	11	r.h	r.h	PROPN
dti-1325	309	12	.	.	PROPN
dti-1325	309	13	and	and	CCONJ
dti-1325	309	14	newman	newman	PROPN
dti-1325	309	15	,	,	PUNCT
dti-1325	309	16	p.j	p.j	PROPN
dti-1325	309	17	.	.	PROPN
dti-1325	309	18	1997	1997	NUM
dti-1325	309	19	.	.	PUNCT
dti-1325	310	1	disruption	disruption	NOUN
dti-1325	310	2	of	of	ADP
dti-1325	310	3	a	a	DET
dti-1325	310	4	long	long	ADJ
dti-1325	310	5	-	-	PUNCT
dti-1325	310	6	range	range	NOUN
dti-1325	310	7	disulfi	disulfi	NOUN
dti-1325	310	8	de	de	X
dti-1325	310	9	bond	bond	NOUN
dti-1325	310	10	between	between	ADP
dti-1325	310	11	residues	residue	NOUN
dti-1325	310	12	cys406	cys406	PROPN
dti-1325	310	13	and	and	CCONJ
dti-1325	310	14	cys655	cys655	NOUN
dti-1325	310	15	in	in	ADP
dti-1325	310	16	glycoprotein	glycoprotein	NOUN
dti-1325	310	17	iiia	iiia	NOUN
dti-1325	310	18	does	do	AUX
dti-1325	310	19	not	not	PART
dti-1325	310	20	affect	affect	VERB
dti-1325	310	21	the	the	DET
dti-1325	310	22	function	function	NOUN
dti-1325	310	23	of	of	ADP
dti-1325	310	24	platelet	platelet	NOUN
dti-1325	310	25	glycoprotein	glycoprotein	NOUN
dti-1325	310	26	iib	iib	PROPN
dti-1325	310	27	-	-	PUNCT
dti-1325	310	28	iiia	iiia	PROPN
dti-1325	310	29	.	.	PUNCT
dti-1325	311	1	blood	blood	NOUN
dti-1325	311	2	,	,	PUNCT
dti-1325	311	3	90:1718–9	90:1718–9	NUM
dti-1325	311	4	.	.	PUNCT
dti-1325	312	1	whitnack	whitnack	NOUN
dti-1325	312	2	,	,	PUNCT
dti-1325	312	3	e.	e.	PROPN
dti-1325	312	4	and	and	CCONJ
dti-1325	312	5	beachey	beachey	PROPN
dti-1325	312	6	,	,	PUNCT
dti-1325	312	7	e.h	e.h	PROPN
dti-1325	312	8	.	.	PROPN
dti-1325	312	9	1985	1985	NUM
dti-1325	312	10	.	.	PUNCT
dti-1325	313	1	biochemical	biochemical	ADJ
dti-1325	313	2	and	and	CCONJ
dti-1325	313	3	biological	biological	ADJ
dti-1325	313	4	properties	property	NOUN
dti-1325	313	5	of	of	ADP
dti-1325	313	6	the	the	DET
dti-1325	313	7	binding	binding	NOUN
dti-1325	313	8	of	of	ADP
dti-1325	313	9	human	human	ADJ
dti-1325	313	10	fi	fi	NOUN
dti-1325	313	11	brinogen	brinogen	NOUN
dti-1325	313	12	to	to	ADP
dti-1325	313	13	m	m	VERB
dti-1325	313	14	protein	protein	NOUN
dti-1325	313	15	in	in	ADP
dti-1325	313	16	group	group	NOUN
dti-1325	313	17	a	a	DET
dti-1325	313	18	streptococci	streptococci	NOUN
dti-1325	313	19	.	.	PUNCT
dti-1325	314	1	j.	j.	PROPN
dti-1325	314	2	bacteriology	bacteriology	PROPN
dti-1325	314	3	,	,	PUNCT
dti-1325	314	4	164:350–8	164:350–8	NUM
dti-1325	314	5	.	.	PUNCT
dti-1325	315	1	<	<	X
dti-1325	315	2	<	<	X
dti-1325	315	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1325	315	4	false	false	ADJ
dti-1325	315	5	/allowtransparency	/allowtransparency	NOUN
dti-1325	315	6	false	false	ADJ
dti-1325	315	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1325	315	8	true	true	ADJ
dti-1325	315	9	/autorotatepages	/autorotatepage	NOUN
dti-1325	315	10	/none	/none	PUNCT
dti-1325	315	11	/binding	/binding	PUNCT
dti-1325	315	12	/left	/left	ADJ
dti-1325	316	1	/calgrayprofile	/calgrayprofile	VERB
dti-1325	316	2	(	(	PUNCT
dti-1325	316	3	dot	dot	NOUN
dti-1325	316	4	gain	gain	NOUN
dti-1325	316	5	20	20	NUM
dti-1325	316	6	%	%	NOUN
dti-1325	316	7	)	)	PUNCT
dti-1325	316	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1325	317	1	(	(	PUNCT
dti-1325	317	2	srgb	srgb	PROPN
dti-1325	317	3	iec61966	iec61966	NOUN
dti-1325	317	4	-	-	PUNCT
dti-1325	317	5	2.1	2.1	NUM
dti-1325	317	6	)	)	PUNCT
dti-1325	317	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1325	318	1	(	(	PUNCT
dti-1325	318	2	u.s	u.s	PROPN
dti-1325	318	3	.	.	PROPN
dti-1325	318	4	web	web	NOUN
dti-1325	318	5	coated	coat	VERB
dti-1325	318	6	\050swop\051	\050swop\051	ADJ
dti-1325	318	7	v2	v2	NOUN
dti-1325	318	8	)	)	PUNCT
dti-1325	318	9	/srgbprofile	/srgbprofile	PUNCT
dti-1325	318	10	(	(	PUNCT
dti-1325	318	11	srgb	srgb	PROPN
dti-1325	318	12	iec61966	iec61966	NOUN
dti-1325	318	13	-	-	PUNCT
dti-1325	318	14	2.1	2.1	NUM
dti-1325	318	15	)	)	PUNCT
dti-1325	318	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1325	319	1	/error	/error	INTJ
dti-1325	319	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1325	320	1	1.4	1.4	NUM
dti-1325	320	2	/compressobjects	/compressobject	NOUN
dti-1325	320	3	/tags	/tag	VERB
dti-1325	320	4	/compresspages	/compresspage	NOUN
dti-1325	320	5	true	true	ADJ
dti-1325	320	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1325	320	7	true	true	ADJ
dti-1325	320	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1325	320	9	true	true	ADJ
dti-1325	320	10	/createjdffile	/createjdffile	ADJ
dti-1325	320	11	false	false	ADJ
dti-1325	320	12	/createjobticket	/createjobticket	NOUN
dti-1325	320	13	false	false	ADJ
dti-1325	320	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1325	320	15	/default	/default	PUNCT
dti-1325	320	16	/detectblends	/detectblend	NOUN
dti-1325	320	17	true	true	ADJ
dti-1325	320	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1325	320	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1325	320	20	/dothumbnails	/dothumbnail	VERB
dti-1325	320	21	false	false	ADJ
dti-1325	320	22	/embedallfonts	/embedallfont	NOUN
dti-1325	320	23	true	true	ADJ
dti-1325	320	24	/embedjoboptions	/embedjoboption	NOUN
dti-1325	320	25	true	true	ADJ
dti-1325	320	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1325	320	27	0	0	NUM
dti-1325	320	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1325	320	29	false	false	ADJ
dti-1325	320	30	/endpage	/endpage	NOUN
dti-1325	320	31	-1	-1	NOUN
dti-1325	320	32	/imagememory	/imagememory	NUM
dti-1325	321	1	1048576	1048576	NUM
dti-1325	321	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1325	321	3	false	false	ADJ
dti-1325	321	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1325	321	5	100	100	NUM
dti-1325	321	6	/optimize	/optimize	NOUN
dti-1325	321	7	true	true	ADJ
dti-1325	321	8	/opm	/opm	NOUN
dti-1325	321	9	1	1	NUM
dti-1325	321	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1325	321	11	true	true	ADJ
dti-1325	321	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1325	321	13	true	true	ADJ
dti-1325	321	14	/preservecopypage	/preservecopypage	NOUN
dti-1325	321	15	true	true	ADJ
dti-1325	321	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1325	321	17	true	true	ADJ
dti-1325	321	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1325	321	19	false	false	ADJ
dti-1325	321	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1325	321	21	false	false	ADJ
dti-1325	321	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1325	321	23	true	true	ADJ
dti-1325	321	24	/startpage	/startpage	NOUN
dti-1325	321	25	1	1	NUM
dti-1325	321	26	/subsetfonts	/subsetfont	NOUN
dti-1325	321	27	true	true	ADJ
dti-1325	321	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1325	321	29	/apply	/apply	PUNCT
dti-1325	321	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1325	322	1	/preserve	/preserve	NOUN
dti-1325	322	2	/useprologue	/useprologue	NOUN
dti-1325	322	3	false	false	ADJ
dti-1325	322	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1325	322	5	(	(	PUNCT
dti-1325	322	6	)	)	PUNCT
dti-1325	322	7	/alwaysembed	/alwaysembe	VERB
dti-1325	322	8	[	[	PUNCT
dti-1325	322	9	true	true	ADJ
dti-1325	322	10	]	]	PUNCT
dti-1325	322	11	/neverembed	/neverembed	PUNCT
dti-1325	323	1	[	[	PUNCT
dti-1325	323	2	true	true	ADJ
dti-1325	323	3	]	]	PUNCT
dti-1325	323	4	/antialiascolorimages	/antialiascolorimages	X
dti-1325	323	5	false	false	ADJ
dti-1325	323	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1325	323	7	true	true	ADJ
dti-1325	323	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1325	323	9	/bicubic	/bicubic	NOUN
dti-1325	323	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1325	323	11	300	300	NUM
dti-1325	323	12	/colorimagedepth	/colorimagedepth	PRON
dti-1325	324	1	-1	-1	INTJ
dti-1325	324	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1325	324	3	1.50000	1.50000	NUM
dti-1325	324	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1325	324	5	true	true	ADJ
dti-1325	324	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1325	324	7	/dctencode	/dctencode	PUNCT
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dti-1325	351	3	>	>	X
dti-1325	351	4	/nld	/nld	PUNCT
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dti-1325	352	3	>	>	X
dti-1325	352	4	/esp	/esp	PUNCT
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dti-1325	353	3	>	>	X
dti-1325	353	4	/suo	/suo	PUNCT
dti-1325	354	1	<	<	X
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dti-1325	354	3	>	>	X
dti-1325	354	4	/ita	/ita	PUNCT
dti-1325	355	1	<	<	X
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dti-1325	355	3	>	>	X
dti-1325	355	4	/nor	/nor	X
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dti-1325	355	7	>	>	X
dti-1325	355	8	/sve	/sve	NOUN
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dti-1325	356	3	>	>	X
dti-1325	356	4	/enu	/enu	PROPN
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dti-1325	356	7	>	>	X
dti-1325	356	8	>	>	X
dti-1325	356	9	>	>	X
dti-1325	356	10	>	>	X
dti-1325	356	11	>	>	X
dti-1325	356	12	setdistillerparams	setdistillerparam	NOUN
dti-1325	357	1	<	<	X
dti-1325	357	2	<	<	X
dti-1325	357	3	/hwresolution	/hwresolution	NOUN
dti-1325	358	1	[	[	X
dti-1325	358	2	2400	2400	NUM
dti-1325	358	3	2400	2400	NUM
dti-1325	358	4	]	]	PUNCT
dti-1325	358	5	/pagesize	/pagesize	X
dti-1325	359	1	[	[	X
dti-1325	359	2	612.000	612.000	NUM
dti-1325	359	3	792.000	792.000	NUM
dti-1325	359	4	]	]	PUNCT
dti-1325	359	5	>	>	PUNCT
dti-1325	359	6	>	>	X
dti-1325	359	7	setpagedevice	setpagedevice	PROPN