id	sid	tid	token	lemma	pos
dti-1327	1	1	doyle	doyle	PROPN
dti-1327	1	2	et	et	PROPN
dti-1327	1	3	al.indd	al.indd	PROPN
dti-1327	1	4	drug	drug	NOUN
dti-1327	1	5	target	target	NOUN
dti-1327	1	6	insights	insight	NOUN
dti-1327	1	7	2008:3	2008:3	NUM
dti-1327	1	8	13–25	13–25	NUM
dti-1327	1	9	13	13	NUM
dti-1327	1	10	original	original	ADJ
dti-1327	1	11	research	research	NOUN
dti-1327	1	12	correspondence	correspondence	NOUN
dti-1327	1	13	:	:	PUNCT
dti-1327	1	14	robert	robert	PROPN
dti-1327	1	15	p.	p.	PROPN
dti-1327	1	16	doyle	doyle	PROPN
dti-1327	1	17	,	,	PUNCT
dti-1327	1	18	department	department	NOUN
dti-1327	1	19	of	of	ADP
dti-1327	1	20	chemistry	chemistry	PROPN
dti-1327	1	21	,	,	PUNCT
dti-1327	1	22	syracuse	syracuse	PROPN
dti-1327	1	23	university	university	PROPN
dti-1327	1	24	,	,	PUNCT
dti-1327	1	25	syracuse	syracuse	PROPN
dti-1327	1	26	,	,	PUNCT
dti-1327	1	27	ny	ny	PROPN
dti-1327	1	28	13244	13244	NUM
dti-1327	1	29	-	-	SYM
dti-1327	1	30	4100	4100	NUM
dti-1327	1	31	,	,	PUNCT
dti-1327	1	32	u.s.a	u.s.a	PROPN
dti-1327	1	33	.	.	PUNCT
dti-1327	2	1	tel	tel	NOUN
dti-1327	2	2	:	:	PUNCT
dti-1327	2	3	+1	+1	PROPN
dti-1327	2	4	315	315	NUM
dti-1327	2	5	443	443	NUM
dti-1327	2	6	3584	3584	NUM
dti-1327	2	7	;	;	PUNCT
dti-1327	2	8	email	email	NOUN
dti-1327	2	9	:	:	PUNCT
dti-1327	2	10	rpdoyle@syr.edu	rpdoyle@syr.edu	VERB
dti-1327	2	11	copyright	copyright	NOUN
dti-1327	2	12	in	in	ADP
dti-1327	2	13	this	this	DET
dti-1327	2	14	article	article	NOUN
dti-1327	2	15	,	,	PUNCT
dti-1327	2	16	its	its	PRON
dti-1327	2	17	metadata	metadata	NOUN
dti-1327	2	18	,	,	PUNCT
dti-1327	2	19	and	and	CCONJ
dti-1327	2	20	any	any	DET
dti-1327	2	21	supplementary	supplementary	ADJ
dti-1327	2	22	data	datum	NOUN
dti-1327	2	23	is	be	AUX
dti-1327	2	24	held	hold	VERB
dti-1327	2	25	by	by	ADP
dti-1327	2	26	its	its	PRON
dti-1327	2	27	author	author	NOUN
dti-1327	2	28	or	or	CCONJ
dti-1327	2	29	authors	author	NOUN
dti-1327	2	30	.	.	PUNCT
dti-1327	3	1	it	it	PRON
dti-1327	3	2	is	be	AUX
dti-1327	3	3	published	publish	VERB
dti-1327	3	4	under	under	ADP
dti-1327	3	5	the	the	DET
dti-1327	3	6	creative	creative	ADJ
dti-1327	3	7	commons	common	NOUN
dti-1327	3	8	attribution	attribution	NOUN
dti-1327	3	9	by	by	ADP
dti-1327	3	10	licence	licence	NOUN
dti-1327	3	11	.	.	PUNCT
dti-1327	4	1	for	for	SCONJ
dti-1327	4	2	further	further	ADJ
dti-1327	4	3	information	information	NOUN
dti-1327	4	4	go	go	VERB
dti-1327	4	5	to	to	ADP
dti-1327	4	6	:	:	PUNCT
dti-1327	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1327	4	8	targeting	target	VERB
dti-1327	4	9	gallium	gallium	NOUN
dti-1327	4	10	to	to	ADP
dti-1327	4	11	cancer	cancer	NOUN
dti-1327	4	12	cells	cell	NOUN
dti-1327	4	13	through	through	ADP
dti-1327	4	14	the	the	DET
dti-1327	4	15	folate	folate	NOUN
dti-1327	4	16	receptor	receptor	NOUN
dti-1327	4	17	nerissa	nerissa	PROPN
dti-1327	4	18	viola	viola	PROPN
dti-1327	4	19	-	-	PUNCT
dti-1327	4	20	villegas	villegas	PROPN
dti-1327	4	21	,	,	PUNCT
dti-1327	4	22	anthony	anthony	PROPN
dti-1327	4	23	vortherms	vortherm	NOUN
dti-1327	4	24	and	and	CCONJ
dti-1327	4	25	robert	robert	PROPN
dti-1327	4	26	p.	p.	PROPN
dti-1327	4	27	doyle	doyle	PROPN
dti-1327	4	28	department	department	PROPN
dti-1327	4	29	of	of	ADP
dti-1327	4	30	chemistry	chemistry	PROPN
dti-1327	4	31	,	,	PUNCT
dti-1327	4	32	syracuse	syracuse	PROPN
dti-1327	4	33	university	university	PROPN
dti-1327	4	34	,	,	PUNCT
dti-1327	4	35	syracuse	syracuse	PROPN
dti-1327	4	36	,	,	PUNCT
dti-1327	4	37	ny	ny	PROPN
dti-1327	4	38	13244	13244	NUM
dti-1327	4	39	-	-	SYM
dti-1327	4	40	4100	4100	NUM
dti-1327	4	41	,	,	PUNCT
dti-1327	5	1	u.s.a	u.s.a	PROPN
dti-1327	5	2	.	.	PUNCT
dti-1327	5	3	abstract	abstract	PROPN
dti-1327	5	4	:	:	PUNCT
dti-1327	5	5	the	the	DET
dti-1327	5	6	development	development	NOUN
dti-1327	5	7	of	of	ADP
dti-1327	5	8	gallium(iii	gallium(iii	PROPN
dti-1327	5	9	)	)	PUNCT
dti-1327	5	10	compounds	compound	NOUN
dti-1327	5	11	as	as	ADP
dti-1327	5	12	anti	anti	ADJ
dti-1327	5	13	-	-	ADJ
dti-1327	5	14	cancer	cancer	ADJ
dti-1327	5	15	agents	agent	NOUN
dti-1327	5	16	for	for	ADP
dti-1327	5	17	both	both	DET
dti-1327	5	18	treatment	treatment	NOUN
dti-1327	5	19	and	and	CCONJ
dti-1327	5	20	diagnosis	diagnosis	NOUN
dti-1327	5	21	is	be	AUX
dti-1327	5	22	a	a	DET
dti-1327	5	23	rapidly	rapidly	ADV
dti-1327	5	24	developing	develop	VERB
dti-1327	5	25	fi	fi	NOUN
dti-1327	5	26	eld	eld	NOUN
dti-1327	5	27	of	of	ADP
dti-1327	5	28	research	research	NOUN
dti-1327	5	29	.	.	PUNCT
dti-1327	6	1	problems	problem	NOUN
dti-1327	6	2	remain	remain	VERB
dti-1327	6	3	in	in	ADP
dti-1327	6	4	exploring	explore	VERB
dti-1327	6	5	the	the	DET
dti-1327	6	6	full	full	ADJ
dti-1327	6	7	potential	potential	NOUN
dti-1327	6	8	of	of	ADP
dti-1327	6	9	gallium(iii	gallium(iii	NOUN
dti-1327	6	10	)	)	PUNCT
dti-1327	6	11	as	as	ADP
dti-1327	6	12	a	a	DET
dti-1327	6	13	safe	safe	ADJ
dti-1327	6	14	and	and	CCONJ
dti-1327	6	15	successful	successful	ADJ
dti-1327	6	16	therapeutic	therapeutic	ADJ
dti-1327	6	17	agent	agent	NOUN
dti-1327	6	18	or	or	CCONJ
dti-1327	6	19	as	as	ADP
dti-1327	6	20	an	an	DET
dti-1327	6	21	imaging	imaging	NOUN
dti-1327	6	22	agent	agent	NOUN
dti-1327	6	23	.	.	PUNCT
dti-1327	7	1	one	one	NUM
dti-1327	7	2	of	of	ADP
dti-1327	7	3	the	the	DET
dti-1327	7	4	major	major	ADJ
dti-1327	7	5	issues	issue	NOUN
dti-1327	7	6	is	be	AUX
dti-1327	7	7	that	that	PRON
dti-1327	7	8	gallium(iii	gallium(iii	NOUN
dti-1327	7	9	)	)	PUNCT
dti-1327	7	10	compounds	compound	NOUN
dti-1327	7	11	have	have	VERB
dti-1327	7	12	little	little	ADJ
dti-1327	7	13	tropism	tropism	NOUN
dti-1327	7	14	for	for	ADP
dti-1327	7	15	cancer	cancer	NOUN
dti-1327	7	16	cells	cell	NOUN
dti-1327	7	17	.	.	PUNCT
dti-1327	8	1	we	we	PRON
dti-1327	8	2	have	have	AUX
dti-1327	8	3	combined	combine	VERB
dti-1327	8	4	the	the	DET
dti-1327	8	5	targeting	targeting	NOUN
dti-1327	8	6	properties	property	NOUN
dti-1327	8	7	of	of	ADP
dti-1327	8	8	folic	folic	ADJ
dti-1327	8	9	acid	acid	NOUN
dti-1327	8	10	(	(	PUNCT
dti-1327	8	11	fa	fa	NOUN
dti-1327	8	12	)	)	PUNCT
dti-1327	8	13	with	with	ADP
dti-1327	8	14	long	long	ADJ
dti-1327	8	15	chain	chain	NOUN
dti-1327	8	16	liquid	liquid	ADJ
dti-1327	8	17	polymer	polymer	NOUN
dti-1327	8	18	poly(ethylene	poly(ethylene	NOUN
dti-1327	8	19	glycol	glycol	NOUN
dti-1327	8	20	)	)	PUNCT
dti-1327	8	21	(	(	PUNCT
dti-1327	8	22	peg	peg	NOUN
dti-1327	8	23	)	)	PUNCT
dti-1327	8	24	‘	'	PUNCT
dti-1327	8	25	spacers	spacer	NOUN
dti-1327	8	26	’	'	PUNCT
dti-1327	8	27	.	.	PUNCT
dti-1327	9	1	this	this	DET
dti-1327	9	2	fa	fa	NOUN
dti-1327	9	3	-	-	PUNCT
dti-1327	9	4	peg	peg	NOUN
dti-1327	9	5	unit	unit	NOUN
dti-1327	9	6	has	have	AUX
dti-1327	9	7	been	be	AUX
dti-1327	9	8	coupled	couple	VERB
dti-1327	9	9	to	to	ADP
dti-1327	9	10	the	the	DET
dti-1327	9	11	gallium	gallium	NOUN
dti-1327	9	12	coordination	coordination	NOUN
dti-1327	9	13	complex	complex	NOUN
dti-1327	9	14	of	of	ADP
dti-1327	9	15	1,4,7,10	1,4,7,10	NUM
dti-1327	9	16	-	-	PUNCT
dti-1327	9	17	tetraazacyclo	tetraazacyclo	NOUN
dti-1327	9	18	-	-	PUNCT
dti-1327	9	19	dodecane	dodecane	NOUN
dti-1327	9	20	-	-	PUNCT
dti-1327	9	21	n	n	NOUN
dti-1327	9	22	,	,	PUNCT
dti-1327	9	23	n′,n′′,n′′′-tetraacetic	n′,n′′,n′′′-tetraacetic	ADJ
dti-1327	9	24	acid	acid	NOUN
dti-1327	9	25	(	(	PUNCT
dti-1327	9	26	dota	dota	PROPN
dti-1327	9	27	)	)	PUNCT
dti-1327	9	28	through	through	ADP
dti-1327	9	29	amide	amide	NOUN
dti-1327	9	30	linkages	linkage	NOUN
dti-1327	9	31	for	for	ADP
dti-1327	9	32	delivery	delivery	NOUN
dti-1327	9	33	into	into	ADP
dti-1327	9	34	target	target	NOUN
dti-1327	9	35	cells	cell	NOUN
dti-1327	9	36	overexpressing	overexpresse	VERB
dti-1327	9	37	the	the	DET
dti-1327	9	38	folate	folate	NOUN
dti-1327	9	39	receptor	receptor	NOUN
dti-1327	9	40	(	(	PUNCT
dti-1327	9	41	fr	fr	NOUN
dti-1327	9	42	)	)	PUNCT
dti-1327	9	43	.	.	PUNCT
dti-1327	10	1	in	in	ADP
dti-1327	10	2	vitro	vitro	X
dti-1327	10	3	cytotoxicity	cytotoxicity	NOUN
dti-1327	10	4	assays	assay	NOUN
dti-1327	10	5	were	be	AUX
dti-1327	10	6	conducted	conduct	VERB
dti-1327	10	7	against	against	ADP
dti-1327	10	8	a	a	DET
dti-1327	10	9	multi	multi	ADJ
dti-1327	10	10	-	-	ADJ
dti-1327	10	11	drug	drug	ADJ
dti-1327	10	12	resistant	resistant	ADJ
dti-1327	10	13	ovarian	ovarian	ADJ
dti-1327	10	14	cell	cell	NOUN
dti-1327	10	15	line	line	NOUN
dti-1327	10	16	(	(	PUNCT
dti-1327	10	17	a2780	a2780	NOUN
dti-1327	10	18	/	/	SYM
dti-1327	10	19	ad	ad	NOUN
dti-1327	10	20	)	)	PUNCT
dti-1327	10	21	that	that	PRON
dti-1327	10	22	overexpresses	overexpresse	VERB
dti-1327	10	23	the	the	DET
dti-1327	10	24	fr	fr	NOUN
dti-1327	10	25	and	and	CCONJ
dti-1327	10	26	contrasted	contrast	VERB
dti-1327	10	27	against	against	ADP
dti-1327	10	28	a	a	DET
dti-1327	10	29	fr	fr	PROPN
dti-1327	10	30	free	free	PROPN
dti-1327	10	31	chinese	chinese	ADJ
dti-1327	10	32	hamster	hamster	PROPN
dti-1327	10	33	ovary	ovary	NOUN
dti-1327	10	34	(	(	PUNCT
dti-1327	10	35	cho	cho	NOUN
dti-1327	10	36	)	)	PUNCT
dti-1327	10	37	cell	cell	NOUN
dti-1327	10	38	line	line	NOUN
dti-1327	10	39	.	.	PUNCT
dti-1327	11	1	results	result	NOUN
dti-1327	11	2	are	be	AUX
dti-1327	11	3	rationalized	rationalize	VERB
dti-1327	11	4	taking	take	VERB
dti-1327	11	5	into	into	ADP
dti-1327	11	6	account	account	NOUN
dti-1327	11	7	stability	stability	NOUN
dti-1327	11	8	studies	study	NOUN
dti-1327	11	9	conducted	conduct	VERB
dti-1327	11	10	in	in	ADP
dti-1327	11	11	rpmi	rpmi	NOUN
dti-1327	11	12	1640	1640	NUM
dti-1327	11	13	media	medium	NOUN
dti-1327	11	14	and	and	CCONJ
dti-1327	11	15	hepes	hepe	NOUN
dti-1327	11	16	buffer	buffer	NOUN
dti-1327	11	17	at	at	ADP
dti-1327	11	18	ph	ph	PROPN
dti-1327	11	19	7.4	7.4	NUM
dti-1327	11	20	.	.	PUNCT
dti-1327	12	1	keywords	keyword	NOUN
dti-1327	12	2	:	:	PUNCT
dti-1327	12	3	folate	folate	NOUN
dti-1327	12	4	receptor	receptor	NOUN
dti-1327	12	5	,	,	PUNCT
dti-1327	12	6	gallium	gallium	NOUN
dti-1327	12	7	,	,	PUNCT
dti-1327	12	8	dota	dota	PROPN
dti-1327	12	9	,	,	PUNCT
dti-1327	12	10	targeting	targeting	NOUN
dti-1327	12	11	,	,	PUNCT
dti-1327	12	12	cytotoxicity	cytotoxicity	NOUN
dti-1327	12	13	introduction	introduction	NOUN
dti-1327	12	14	the	the	DET
dti-1327	12	15	anti	anti	ADJ
dti-1327	12	16	-	-	ADJ
dti-1327	12	17	cancer	cancer	ADJ
dti-1327	12	18	properties	property	NOUN
dti-1327	12	19	of	of	ADP
dti-1327	12	20	gallium(iii	gallium(iii	NOUN
dti-1327	12	21	)	)	PUNCT
dti-1327	12	22	have	have	AUX
dti-1327	12	23	been	be	AUX
dti-1327	12	24	extensively	extensively	ADV
dti-1327	12	25	investigated	investigate	VERB
dti-1327	12	26	since	since	SCONJ
dti-1327	12	27	1971	1971	NUM
dti-1327	12	28	(	(	PUNCT
dti-1327	12	29	hart	hart	PROPN
dti-1327	12	30	et	et	PROPN
dti-1327	12	31	al	al	PROPN
dti-1327	12	32	.	.	PROPN
dti-1327	12	33	1971	1971	NUM
dti-1327	12	34	)	)	PUNCT
dti-1327	12	35	.	.	PUNCT
dti-1327	13	1	gallium	gallium	NOUN
dti-1327	13	2	has	have	VERB
dti-1327	13	3	numerous	numerous	ADJ
dti-1327	13	4	ways	way	NOUN
dti-1327	13	5	to	to	PART
dti-1327	13	6	induce	induce	VERB
dti-1327	13	7	cell	cell	NOUN
dti-1327	13	8	death	death	NOUN
dti-1327	13	9	,	,	PUNCT
dti-1327	13	10	including	include	VERB
dti-1327	13	11	dna	dna	PROPN
dti-1327	13	12	binding	binding	NOUN
dti-1327	13	13	and	and	CCONJ
dti-1327	13	14	modifi	modifi	NOUN
dti-1327	13	15	cation	cation	NOUN
dti-1327	13	16	(	(	PUNCT
dti-1327	13	17	hedley	hedley	PROPN
dti-1327	13	18	et	et	PROPN
dti-1327	13	19	al	al	PROPN
dti-1327	13	20	.	.	PROPN
dti-1327	13	21	1988	1988	NUM
dti-1327	13	22	)	)	PUNCT
dti-1327	13	23	,	,	PUNCT
dti-1327	13	24	enzyme	enzyme	NOUN
dti-1327	13	25	inhibition	inhibition	NOUN
dti-1327	13	26	(	(	PUNCT
dti-1327	13	27	especially	especially	ADV
dti-1327	13	28	ribonucleotide	ribonucleotide	ADJ
dti-1327	13	29	reductase	reductase	NOUN
dti-1327	13	30	)	)	PUNCT
dti-1327	13	31	(	(	PUNCT
dti-1327	13	32	chitambar	chitambar	NOUN
dti-1327	13	33	et	et	PROPN
dti-1327	13	34	al	al	PROPN
dti-1327	13	35	.	.	PROPN
dti-1327	13	36	1988	1988	NUM
dti-1327	13	37	)	)	PUNCT
dti-1327	13	38	,	,	PUNCT
dti-1327	13	39	and	and	CCONJ
dti-1327	13	40	ion	ion	NOUN
dti-1327	13	41	transport	transport	NOUN
dti-1327	13	42	disruption	disruption	NOUN
dti-1327	13	43	(	(	PUNCT
dti-1327	13	44	such	such	ADJ
dti-1327	13	45	as	as	ADP
dti-1327	13	46	calcium	calcium	NOUN
dti-1327	13	47	effl	effl	PROPN
dti-1327	13	48	ux	ux	PROPN
dti-1327	13	49	from	from	ADP
dti-1327	13	50	mitochondria	mitochondria	PROPN
dti-1327	13	51	)	)	PUNCT
dti-1327	13	52	,	,	PUNCT
dti-1327	13	53	a	a	DET
dti-1327	13	54	known	know	VERB
dti-1327	13	55	trigger	trigger	NOUN
dti-1327	13	56	of	of	ADP
dti-1327	13	57	cellular	cellular	ADJ
dti-1327	13	58	apoptosis	apoptosis	NOUN
dti-1327	13	59	(	(	PUNCT
dti-1327	13	60	collery	collery	NOUN
dti-1327	13	61	et	et	PROPN
dti-1327	13	62	al	al	PROPN
dti-1327	13	63	.	.	PROPN
dti-1327	13	64	1996	1996	NUM
dti-1327	13	65	)	)	PUNCT
dti-1327	13	66	.	.	PUNCT
dti-1327	14	1	in	in	ADP
dti-1327	14	2	general	general	ADJ
dti-1327	14	3	,	,	PUNCT
dti-1327	14	4	the	the	DET
dti-1327	14	5	poor	poor	ADJ
dti-1327	14	6	pharmacokinetic	pharmacokinetic	ADJ
dti-1327	14	7	properties	property	NOUN
dti-1327	14	8	of	of	ADP
dti-1327	14	9	gallium	gallium	NOUN
dti-1327	14	10	salts	salt	NOUN
dti-1327	14	11	investigated	investigate	VERB
dti-1327	14	12	have	have	AUX
dti-1327	14	13	prevented	prevent	VERB
dti-1327	14	14	their	their	PRON
dti-1327	14	15	widespread	widespread	ADJ
dti-1327	14	16	use	use	NOUN
dti-1327	14	17	in	in	ADP
dti-1327	14	18	chemotherapy	chemotherapy	NOUN
dti-1327	14	19	.	.	PUNCT
dti-1327	15	1	efforts	effort	NOUN
dti-1327	15	2	to	to	PART
dti-1327	15	3	develop	develop	VERB
dti-1327	15	4	gallium	gallium	NOUN
dti-1327	15	5	complexes	complex	NOUN
dti-1327	15	6	to	to	PART
dti-1327	15	7	improve	improve	VERB
dti-1327	15	8	its	its	PRON
dti-1327	15	9	profi	profi	PROPN
dti-1327	15	10	le	le	X
dti-1327	15	11	,	,	PUNCT
dti-1327	15	12	by	by	ADP
dti-1327	15	13	addressing	address	VERB
dti-1327	15	14	the	the	DET
dti-1327	15	15	problems	problem	NOUN
dti-1327	15	16	of	of	ADP
dti-1327	15	17	hydrolysis	hydrolysis	NOUN
dti-1327	15	18	,	,	PUNCT
dti-1327	15	19	poor	poor	ADJ
dti-1327	15	20	absorption	absorption	NOUN
dti-1327	15	21	,	,	PUNCT
dti-1327	15	22	poor	poor	ADJ
dti-1327	15	23	solubility	solubility	NOUN
dti-1327	15	24	,	,	PUNCT
dti-1327	15	25	rapid	rapid	ADJ
dti-1327	15	26	renal	renal	ADJ
dti-1327	15	27	excretion	excretion	NOUN
dti-1327	15	28	and	and	CCONJ
dti-1327	15	29	little	little	ADJ
dti-1327	15	30	tropism	tropism	NOUN
dti-1327	15	31	for	for	ADP
dti-1327	15	32	cancer	cancer	NOUN
dti-1327	15	33	cells	cell	NOUN
dti-1327	15	34	are	be	AUX
dti-1327	15	35	currently	currently	ADV
dti-1327	15	36	underway	underway	ADJ
dti-1327	15	37	(	(	PUNCT
dti-1327	15	38	keppler	keppler	NOUN
dti-1327	15	39	and	and	CCONJ
dti-1327	15	40	jakupec	jakupec	PROPN
dti-1327	15	41	,	,	PUNCT
dti-1327	15	42	2004	2004	NUM
dti-1327	15	43	;	;	PUNCT
dti-1327	15	44	desoize	desoize	NOUN
dti-1327	15	45	,	,	PUNCT
dti-1327	15	46	2004	2004	NUM
dti-1327	15	47	)	)	PUNCT
dti-1327	15	48	.	.	PUNCT
dti-1327	16	1	complexes	complex	NOUN
dti-1327	16	2	such	such	ADJ
dti-1327	16	3	as	as	ADP
dti-1327	16	4	those	those	PRON
dti-1327	16	5	produced	produce	VERB
dti-1327	16	6	by	by	ADP
dti-1327	16	7	the	the	DET
dti-1327	16	8	groups	group	NOUN
dti-1327	16	9	of	of	ADP
dti-1327	16	10	keppler	keppler	NOUN
dti-1327	16	11	(	(	PUNCT
dti-1327	16	12	keppler	keppler	NOUN
dti-1327	16	13	et	et	PROPN
dti-1327	16	14	al	al	PROPN
dti-1327	16	15	.	.	PROPN
dti-1327	16	16	2006	2006	NUM
dti-1327	16	17	)	)	PUNCT
dti-1327	16	18	,	,	PUNCT
dti-1327	16	19	sharma	sharma	PROPN
dti-1327	16	20	(	(	PUNCT
dti-1327	16	21	sharma	sharma	PROPN
dti-1327	16	22	et	et	PROPN
dti-1327	16	23	al	al	PROPN
dti-1327	16	24	.	.	PROPN
dti-1327	16	25	2007	2007	NUM
dti-1327	16	26	)	)	PUNCT
dti-1327	16	27	,	,	PUNCT
dti-1327	16	28	low	low	ADJ
dti-1327	16	29	and	and	CCONJ
dti-1327	16	30	green	green	ADJ
dti-1327	16	31	(	(	PUNCT
dti-1327	16	32	low	low	ADJ
dti-1327	16	33	and	and	CCONJ
dti-1327	16	34	green	green	ADJ
dti-1327	16	35	et	et	PROPN
dti-1327	16	36	al	al	PROPN
dti-1327	16	37	.	.	PROPN
dti-1327	16	38	1996	1996	NUM
dti-1327	16	39	)	)	PUNCT
dti-1327	16	40	have	have	AUX
dti-1327	16	41	been	be	AUX
dti-1327	16	42	successful	successful	ADJ
dti-1327	16	43	in	in	ADP
dti-1327	16	44	increasing	increase	VERB
dti-1327	16	45	plasma	plasma	NOUN
dti-1327	16	46	concentrations	concentration	NOUN
dti-1327	16	47	of	of	ADP
dti-1327	16	48	gallium	gallium	NOUN
dti-1327	16	49	,	,	PUNCT
dti-1327	16	50	providing	provide	VERB
dti-1327	16	51	better	well	ADJ
dti-1327	16	52	antiproliferative	antiproliferative	ADJ
dti-1327	16	53	effects	effect	NOUN
dti-1327	16	54	or	or	CCONJ
dti-1327	16	55	improved	improve	VERB
dti-1327	16	56	imaging	imaging	NOUN
dti-1327	16	57	of	of	ADP
dti-1327	16	58	cancer	cancer	NOUN
dti-1327	16	59	cells	cell	NOUN
dti-1327	16	60	(	(	PUNCT
dti-1327	16	61	when	when	SCONJ
dti-1327	16	62	using	use	VERB
dti-1327	16	63	gallium	gallium	NOUN
dti-1327	16	64	radioactive	radioactive	ADJ
dti-1327	16	65	isotopes	isotope	NOUN
dti-1327	16	66	(	(	PUNCT
dti-1327	16	67	67ga	67ga	NOUN
dti-1327	16	68	γ	γ	X
dti-1327	16	69	,	,	PUNCT
dti-1327	16	70	68ga	68ga	ADJ
dti-1327	16	71	β+	β+	PUNCT
dti-1327	16	72	)	)	PUNCT
dti-1327	16	73	)	)	PUNCT
dti-1327	17	1	(	(	PUNCT
dti-1327	17	2	greenwood	greenwood	PROPN
dti-1327	17	3	and	and	CCONJ
dti-1327	17	4	earnshaw	earnshaw	PROPN
dti-1327	17	5	,	,	PUNCT
dti-1327	17	6	2005	2005	NUM
dti-1327	17	7	)	)	PUNCT
dti-1327	17	8	.	.	PUNCT
dti-1327	18	1	problems	problem	NOUN
dti-1327	18	2	still	still	ADV
dti-1327	18	3	remain	remain	VERB
dti-1327	18	4	however	however	ADV
dti-1327	18	5	especially	especially	ADV
dti-1327	18	6	in	in	ADP
dti-1327	18	7	regards	regard	NOUN
dti-1327	18	8	to	to	ADP
dti-1327	18	9	renal	renal	ADJ
dti-1327	18	10	retention	retention	NOUN
dti-1327	18	11	times	time	NOUN
dti-1327	18	12	and	and	CCONJ
dti-1327	18	13	cancer	cancer	NOUN
dti-1327	18	14	cell	cell	NOUN
dti-1327	18	15	targeting	target	VERB
dti-1327	18	16	.	.	PUNCT
dti-1327	19	1	folic	folic	ADJ
dti-1327	19	2	acid	acid	NOUN
dti-1327	19	3	(	(	PUNCT
dti-1327	19	4	fa	fa	NOUN
dti-1327	19	5	)	)	PUNCT
dti-1327	19	6	(	(	PUNCT
dti-1327	19	7	see	see	VERB
dti-1327	19	8	fig	fig	NOUN
dti-1327	19	9	.	.	PUNCT
dti-1327	19	10	1	1	NUM
dti-1327	19	11	)	)	PUNCT
dti-1327	19	12	is	be	AUX
dti-1327	19	13	a	a	DET
dti-1327	19	14	vitamin	vitamin	NOUN
dti-1327	19	15	potentially	potentially	ADV
dti-1327	19	16	capable	capable	ADJ
dti-1327	19	17	of	of	ADP
dti-1327	19	18	delivering	deliver	VERB
dti-1327	19	19	agents	agent	NOUN
dti-1327	19	20	specifi	specifi	VERB
dti-1327	19	21	cally	cally	ADV
dti-1327	19	22	to	to	PART
dti-1327	19	23	folic	folic	VERB
dti-1327	19	24	acid	acid	NOUN
dti-1327	19	25	-	-	PUNCT
dti-1327	19	26	receptor	receptor	NOUN
dti-1327	19	27	(	(	PUNCT
dti-1327	19	28	fr	fr	NOUN
dti-1327	19	29	)	)	PUNCT
dti-1327	19	30	positive	positive	ADJ
dti-1327	19	31	tumors	tumor	NOUN
dti-1327	19	32	(	(	PUNCT
dti-1327	19	33	lee	lee	PROPN
dti-1327	19	34	and	and	CCONJ
dti-1327	19	35	sudimack	sudimack	VERB
dti-1327	19	36	,	,	PUNCT
dti-1327	19	37	2000	2000	NUM
dti-1327	19	38	)	)	PUNCT
dti-1327	19	39	.	.	PUNCT
dti-1327	20	1	frs	frs	PROPN
dti-1327	20	2	are	be	AUX
dti-1327	20	3	membrane	membrane	NOUN
dti-1327	20	4	glyco	glyco	NOUN
dti-1327	20	5	-	-	PUNCT
dti-1327	20	6	proteins	protein	NOUN
dti-1327	20	7	(	(	PUNCT
dti-1327	20	8	anderson	anderson	PROPN
dti-1327	20	9	et	et	PROPN
dti-1327	20	10	al	al	PROPN
dti-1327	20	11	.	.	PROPN
dti-1327	20	12	1990	1990	NUM
dti-1327	20	13	)	)	PUNCT
dti-1327	20	14	overexpressed	overexpresse	VERB
dti-1327	20	15	by	by	ADP
dti-1327	20	16	a	a	DET
dti-1327	20	17	number	number	NOUN
dti-1327	20	18	of	of	ADP
dti-1327	20	19	tumor	tumor	NOUN
dti-1327	20	20	cell	cell	NOUN
dti-1327	20	21	types	type	NOUN
dti-1327	20	22	such	such	ADJ
dti-1327	20	23	as	as	ADP
dti-1327	20	24	ovarian	ovarian	ADJ
dti-1327	20	25	,	,	PUNCT
dti-1327	20	26	breast	breast	NOUN
dti-1327	20	27	,	,	PUNCT
dti-1327	20	28	cervical	cervical	ADJ
dti-1327	20	29	,	,	PUNCT
dti-1327	20	30	colorectal	colorectal	ADJ
dti-1327	20	31	,	,	PUNCT
dti-1327	20	32	renal	renal	ADJ
dti-1327	20	33	and	and	CCONJ
dti-1327	20	34	nasopharyngeal	nasopharyngeal	ADJ
dti-1327	20	35	cancers	cancer	NOUN
dti-1327	20	36	(	(	PUNCT
dti-1327	20	37	antony	antony	NOUN
dti-1327	20	38	,	,	PUNCT
dti-1327	20	39	1996	1996	NUM
dti-1327	20	40	)	)	PUNCT
dti-1327	20	41	.	.	PUNCT
dti-1327	21	1	cells	cell	NOUN
dti-1327	21	2	overexpressing	overexpresse	VERB
dti-1327	21	3	the	the	DET
dti-1327	21	4	fr	fr	PROPN
dti-1327	21	5	bind	bind	VERB
dti-1327	21	6	fa	fa	NOUN
dti-1327	21	7	-	-	PUNCT
dti-1327	21	8	drug	drug	NOUN
dti-1327	21	9	conjugates	conjugate	NOUN
dti-1327	21	10	tightly	tightly	ADV
dti-1327	21	11	(	(	PUNCT
dti-1327	21	12	kd	kd	PROPN
dti-1327	21	13	∼	∼	VERB
dti-1327	21	14	0.42	0.42	NUM
dti-1327	21	15	×	×	NOUN
dti-1327	21	16	10−9	10−9	NUM
dti-1327	21	17	m	m	NOUN
dti-1327	21	18	)	)	PUNCT
dti-1327	21	19	(	(	PUNCT
dti-1327	21	20	shen	shen	NOUN
dti-1327	21	21	et	et	PROPN
dti-1327	21	22	al	al	PROPN
dti-1327	21	23	.	.	PROPN
dti-1327	21	24	1995	1995	NUM
dti-1327	21	25	)	)	PUNCT
dti-1327	21	26	and	and	CCONJ
dti-1327	21	27	endocytose	endocytose	ADP
dti-1327	21	28	them	they	PRON
dti-1327	21	29	inside	inside	ADV
dti-1327	21	30	(	(	PUNCT
dti-1327	21	31	anderson	anderson	PROPN
dti-1327	21	32	et	et	PROPN
dti-1327	21	33	al	al	PROPN
dti-1327	21	34	.	.	PROPN
dti-1327	21	35	1988	1988	NUM
dti-1327	21	36	)	)	PUNCT
dti-1327	21	37	,	,	PUNCT
dti-1327	21	38	provided	provide	VERB
dti-1327	21	39	that	that	SCONJ
dti-1327	21	40	chemical	chemical	PROPN
dti-1327	21	41	modifi	modifi	NOUN
dti-1327	21	42	cation	cation	NOUN
dti-1327	21	43	of	of	ADP
dti-1327	21	44	the	the	DET
dti-1327	21	45	fa	fa	PROPN
dti-1327	21	46	upon	upon	SCONJ
dti-1327	21	47	conjugation	conjugation	NOUN
dti-1327	21	48	does	do	AUX
dti-1327	21	49	not	not	PART
dti-1327	21	50	disrupt	disrupt	VERB
dti-1327	21	51	recognition	recognition	NOUN
dti-1327	21	52	by	by	ADP
dti-1327	21	53	the	the	DET
dti-1327	21	54	fr	fr	PROPN
dti-1327	21	55	(	(	PUNCT
dti-1327	21	56	liu	liu	PROPN
dti-1327	21	57	et	et	PROPN
dti-1327	21	58	al	al	PROPN
dti-1327	21	59	.	.	PROPN
dti-1327	21	60	2005	2005	NUM
dti-1327	21	61	)	)	PUNCT
dti-1327	21	62	.	.	PUNCT
dti-1327	22	1	targeting	target	VERB
dti-1327	22	2	the	the	DET
dti-1327	22	3	fr	fr	NOUN
dti-1327	22	4	is	be	AUX
dti-1327	22	5	attractive	attractive	ADJ
dti-1327	22	6	because	because	SCONJ
dti-1327	22	7	in	in	ADP
dti-1327	22	8	addition	addition	NOUN
dti-1327	22	9	to	to	ADP
dti-1327	22	10	being	be	AUX
dti-1327	22	11	overexpressed	overexpresse	VERB
dti-1327	22	12	in	in	ADP
dti-1327	22	13	tumor	tumor	NOUN
dti-1327	22	14	lines	line	NOUN
dti-1327	22	15	,	,	PUNCT
dti-1327	22	16	it	it	PRON
dti-1327	22	17	is	be	AUX
dti-1327	22	18	downregulated	downregulate	VERB
dti-1327	22	19	(	(	PUNCT
dti-1327	22	20	and	and	CCONJ
dti-1327	22	21	inaccessible	inaccessible	ADJ
dti-1327	22	22	to	to	ADP
dti-1327	22	23	blood	blood	NOUN
dti-1327	22	24	circulation	circulation	NOUN
dti-1327	22	25	)	)	PUNCT
dti-1327	22	26	in	in	ADP
dti-1327	22	27	healthy	healthy	ADJ
dti-1327	22	28	adult	adult	NOUN
dti-1327	22	29	cells	cell	NOUN
dti-1327	22	30	(	(	PUNCT
dti-1327	22	31	anderson	anderson	PROPN
dti-1327	22	32	et	et	PROPN
dti-1327	22	33	al	al	PROPN
dti-1327	22	34	.	.	PROPN
dti-1327	22	35	1988	1988	NUM
dti-1327	22	36	)	)	PUNCT
dti-1327	22	37	.	.	PUNCT
dti-1327	23	1	we	we	PRON
dti-1327	23	2	are	be	AUX
dti-1327	23	3	primarily	primarily	ADV
dti-1327	23	4	focused	focus	VERB
dti-1327	23	5	on	on	ADP
dti-1327	23	6	ovarian	ovarian	ADJ
dti-1327	23	7	tumors	tumor	NOUN
dti-1327	23	8	since	since	SCONJ
dti-1327	23	9	they	they	PRON
dti-1327	23	10	have	have	AUX
dti-1327	23	11	been	be	AUX
dti-1327	23	12	shown	show	VERB
dti-1327	23	13	to	to	PART
dti-1327	23	14	greatly	greatly	ADV
dti-1327	23	15	overexpress	overexpress	VERB
dti-1327	23	16	the	the	DET
dti-1327	23	17	fr	fr	NOUN
dti-1327	23	18	(	(	PUNCT
dti-1327	23	19	see	see	VERB
dti-1327	23	20	table	table	NOUN
dti-1327	23	21	1	1	NUM
dti-1327	23	22	)	)	PUNCT
dti-1327	23	23	.	.	PUNCT
dti-1327	24	1	current	current	ADJ
dti-1327	24	2	treatments	treatment	NOUN
dti-1327	24	3	for	for	ADP
dti-1327	24	4	ovarian	ovarian	ADJ
dti-1327	24	5	cancer	cancer	NOUN
dti-1327	24	6	have	have	VERB
dti-1327	24	7	a	a	DET
dti-1327	24	8	number	number	NOUN
dti-1327	24	9	of	of	ADP
dti-1327	24	10	serious	serious	ADJ
dti-1327	24	11	side	side	NOUN
dti-1327	24	12	effects	effect	NOUN
dti-1327	24	13	associated	associate	VERB
dti-1327	24	14	with	with	ADP
dti-1327	24	15	their	their	PRON
dti-1327	24	16	use	use	NOUN
dti-1327	24	17	including	include	VERB
dti-1327	24	18	kidney	kidney	NOUN
dti-1327	24	19	damage	damage	NOUN
dti-1327	24	20	,	,	PUNCT
dti-1327	24	21	hearing	hear	VERB
dti-1327	24	22	loss	loss	NOUN
dti-1327	24	23	and	and	CCONJ
dti-1327	24	24	even	even	ADV
dti-1327	24	25	secondary	secondary	ADJ
dti-1327	24	26	cancers	cancer	NOUN
dti-1327	24	27	(	(	PUNCT
dti-1327	24	28	sun	sun	PROPN
dti-1327	24	29	et	et	PROPN
dti-1327	24	30	al	al	PROPN
dti-1327	24	31	.	.	PROPN
dti-1327	24	32	2002	2002	NUM
dti-1327	24	33	)	)	PUNCT
dti-1327	24	34	.	.	PUNCT
dti-1327	25	1	in	in	ADP
dti-1327	25	2	addition	addition	NOUN
dti-1327	25	3	,	,	PUNCT
dti-1327	25	4	over	over	ADP
dti-1327	25	5	75	75	NUM
dti-1327	25	6	%	%	NOUN
dti-1327	25	7	of	of	ADP
dti-1327	25	8	patients	patient	NOUN
dti-1327	25	9	are	be	AUX
dti-1327	25	10	diagnosed	diagnose	VERB
dti-1327	25	11	when	when	SCONJ
dti-1327	25	12	the	the	DET
dti-1327	25	13	disease	disease	NOUN
dti-1327	25	14	has	have	AUX
dti-1327	25	15	already	already	ADV
dti-1327	25	16	progressed	progress	VERB
dti-1327	25	17	to	to	PART
dti-1327	25	18	stage	stage	VERB
dti-1327	25	19	iii	iii	NUM
dti-1327	25	20	or	or	CCONJ
dti-1327	25	21	iv	iv	NUM
dti-1327	25	22	,	,	PUNCT
dti-1327	25	23	with	with	ADP
dti-1327	25	24	only	only	ADV
dti-1327	25	25	a	a	DET
dti-1327	25	26	10%–20	10%–20	NUM
dti-1327	25	27	%	%	NOUN
dti-1327	25	28	5	5	NUM
dti-1327	25	29	year	year	NOUN
dti-1327	25	30	survival	survival	NOUN
dti-1327	25	31	rates	rate	NOUN
dti-1327	25	32	,	,	PUNCT
dti-1327	25	33	respectively	respectively	ADV
dti-1327	25	34	(	(	PUNCT
dti-1327	25	35	ries	rie	NOUN
dti-1327	25	36	,	,	PUNCT
dti-1327	25	37	1993	1993	NUM
dti-1327	25	38	)	)	PUNCT
dti-1327	25	39	.	.	PUNCT
dti-1327	26	1	new	new	ADJ
dti-1327	26	2	ways	way	NOUN
dti-1327	26	3	to	to	PART
dti-1327	26	4	diagnose	diagnose	VERB
dti-1327	26	5	and/or	and/or	CCONJ
dti-1327	26	6	treat	treat	VERB
dti-1327	26	7	this	this	DET
dti-1327	26	8	illness	illness	NOUN
dti-1327	26	9	are	be	AUX
dti-1327	26	10	therefore	therefore	ADV
dti-1327	26	11	urgently	urgently	ADV
dti-1327	26	12	needed	need	VERB
dti-1327	26	13	.	.	PUNCT
dti-1327	27	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1327	27	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1327	27	3	14	14	NUM
dti-1327	27	4	viola	viola	PROPN
dti-1327	27	5	-	-	PUNCT
dti-1327	27	6	villegas	villegas	PROPN
dti-1327	27	7	et	et	PROPN
dti-1327	27	8	al	al	PROPN
dti-1327	27	9	drug	drug	PROPN
dti-1327	27	10	target	target	NOUN
dti-1327	27	11	insights	insight	NOUN
dti-1327	27	12	2008:3	2008:3	NUM
dti-1327	27	13	we	we	PRON
dti-1327	27	14	set	set	VERB
dti-1327	27	15	out	out	ADP
dti-1327	27	16	to	to	PART
dti-1327	27	17	synthesize	synthesize	VERB
dti-1327	27	18	,	,	PUNCT
dti-1327	27	19	purify	purify	VERB
dti-1327	27	20	and	and	CCONJ
dti-1327	27	21	evaluate	evaluate	VERB
dti-1327	27	22	in	in	ADP
dti-1327	27	23	vitro	vitro	X
dti-1327	27	24	a	a	DET
dti-1327	27	25	new	new	ADJ
dti-1327	27	26	fa	fa	NOUN
dti-1327	27	27	bioconjugate	bioconjugate	NOUN
dti-1327	27	28	of	of	ADP
dti-1327	27	29	gallium	gallium	NOUN
dti-1327	27	30	and	and	CCONJ
dti-1327	27	31	compare	compare	VERB
dti-1327	27	32	its	its	PRON
dti-1327	27	33	activity	activity	NOUN
dti-1327	27	34	to	to	ADP
dti-1327	27	35	the	the	DET
dti-1327	27	36	unconjugated	unconjugated	ADJ
dti-1327	27	37	gallium	gallium	NOUN
dti-1327	27	38	analog	analog	NOUN
dti-1327	27	39	.	.	PUNCT
dti-1327	28	1	we	we	PRON
dti-1327	28	2	began	begin	VERB
dti-1327	28	3	by	by	ADP
dti-1327	28	4	initially	initially	ADV
dti-1327	28	5	complexing	complexe	VERB
dti-1327	28	6	gallium	gallium	NOUN
dti-1327	28	7	(	(	PUNCT
dti-1327	28	8	iii	iii	NOUN
dti-1327	28	9	)	)	PUNCT
dti-1327	28	10	to	to	ADP
dti-1327	28	11	the	the	DET
dti-1327	28	12	1,4,7,10	1,4,7,10	NUM
dti-1327	28	13	-	-	PUNCT
dti-1327	28	14	tetraazacyclo	tetraazacyclo	NOUN
dti-1327	28	15	-	-	PUNCT
dti-1327	28	16	dodecanen	dodecanen	NOUN
dti-1327	28	17	,	,	PUNCT
dti-1327	28	18	n′,n′′,n′′′-tetraacetic	n′,n′′,n′′′-tetraacetic	ADJ
dti-1327	28	19	acid	acid	NOUN
dti-1327	28	20	(	(	PUNCT
dti-1327	28	21	dota	dota	PROPN
dti-1327	28	22	)	)	PUNCT
dti-1327	28	23	ligand	ligand	NOUN
dti-1327	28	24	(	(	PUNCT
dti-1327	28	25	doyle	doyle	PROPN
dti-1327	28	26	et	et	PROPN
dti-1327	28	27	al	al	PROPN
dti-1327	28	28	.	.	PROPN
dti-1327	28	29	2006	2006	NUM
dti-1327	28	30	)	)	PUNCT
dti-1327	28	31	.	.	PUNCT
dti-1327	29	1	we	we	PRON
dti-1327	29	2	have	have	AUX
dti-1327	29	3	previously	previously	ADV
dti-1327	29	4	described	describe	VERB
dti-1327	29	5	the	the	DET
dti-1327	29	6	synthesis	synthesis	NOUN
dti-1327	29	7	and	and	CCONJ
dti-1327	29	8	solid	solid	ADJ
dti-1327	29	9	state	state	NOUN
dti-1327	29	10	structure	structure	NOUN
dti-1327	29	11	of	of	ADP
dti-1327	29	12	this	this	DET
dti-1327	29	13	system	system	NOUN
dti-1327	29	14	(	(	PUNCT
dti-1327	29	15	see	see	VERB
dti-1327	29	16	fig	fig	NOUN
dti-1327	29	17	.	.	PUNCT
dti-1327	30	1	2	2	NUM
dti-1327	30	2	)	)	PUNCT
dti-1327	30	3	.	.	PUNCT
dti-1327	31	1	preceding	precede	VERB
dti-1327	31	2	literature	literature	NOUN
dti-1327	31	3	reports	report	NOUN
dti-1327	31	4	have	have	AUX
dti-1327	31	5	demonstrated	demonstrate	VERB
dti-1327	31	6	good	good	ADJ
dti-1327	31	7	kinetic	kinetic	ADJ
dti-1327	31	8	and	and	CCONJ
dti-1327	31	9	thermodynamic	thermodynamic	ADJ
dti-1327	31	10	stability	stability	NOUN
dti-1327	31	11	provided	provide	VERB
dti-1327	31	12	by	by	ADP
dti-1327	31	13	the	the	DET
dti-1327	31	14	dota	dota	PROPN
dti-1327	31	15	ligand	ligand	NOUN
dti-1327	31	16	in	in	ADP
dti-1327	31	17	its	its	PRON
dti-1327	31	18	coordination	coordination	NOUN
dti-1327	31	19	chemistry	chemistry	NOUN
dti-1327	31	20	and	and	CCONJ
dti-1327	31	21	we	we	PRON
dti-1327	31	22	wished	wish	VERB
dti-1327	31	23	to	to	PART
dti-1327	31	24	exploit	exploit	VERB
dti-1327	31	25	this	this	PRON
dti-1327	31	26	coupled	couple	VERB
dti-1327	31	27	with	with	ADP
dti-1327	31	28	folate	folate	NOUN
dti-1327	31	29	receptor	receptor	NOUN
dti-1327	31	30	(	(	PUNCT
dti-1327	31	31	fr	fr	ADV
dti-1327	31	32	)	)	PUNCT
dti-1327	31	33	targeting	target	VERB
dti-1327	31	34	conjugates	conjugate	NOUN
dti-1327	31	35	.	.	PUNCT
dti-1327	32	1	in	in	ADP
dti-1327	32	2	addition	addition	NOUN
dti-1327	32	3	to	to	ADP
dti-1327	32	4	coupling	couple	VERB
dti-1327	32	5	the	the	DET
dti-1327	32	6	gallium	gallium	NOUN
dti-1327	32	7	-	-	PUNCT
dti-1327	32	8	dota	dota	NOUN
dti-1327	32	9	complex	complex	NOUN
dti-1327	32	10	to	to	PART
dti-1327	32	11	folic	folic	VERB
dti-1327	32	12	acid	acid	NOUN
dti-1327	32	13	we	we	PRON
dti-1327	32	14	wished	wish	VERB
dti-1327	32	15	to	to	PART
dti-1327	32	16	include	include	VERB
dti-1327	32	17	poly(ethylene	poly(ethylene	ADJ
dti-1327	32	18	glycol	glycol	NOUN
dti-1327	32	19	)	)	PUNCT
dti-1327	32	20	(	(	PUNCT
dti-1327	32	21	peg	peg	NOUN
dti-1327	32	22	)	)	PUNCT
dti-1327	32	23	polymer	polymer	NOUN
dti-1327	32	24	linkers	linker	NOUN
dti-1327	32	25	between	between	ADP
dti-1327	32	26	the	the	DET
dti-1327	32	27	fa	fa	PROPN
dti-1327	32	28	and	and	CCONJ
dti-1327	32	29	gallium	gallium	NOUN
dti-1327	32	30	complex	complex	NOUN
dti-1327	32	31	since	since	SCONJ
dti-1327	32	32	‘	'	PUNCT
dti-1327	32	33	pegylated	pegylated	ADJ
dti-1327	32	34	’	'	PUNCT
dti-1327	32	35	fa	fa	NOUN
dti-1327	32	36	conjugates	conjugate	NOUN
dti-1327	32	37	have	have	AUX
dti-1327	32	38	been	be	AUX
dti-1327	32	39	shown	show	VERB
dti-1327	32	40	to	to	PART
dti-1327	32	41	have	have	VERB
dti-1327	32	42	greater	great	ADJ
dti-1327	32	43	affi	affi	ADJ
dti-1327	32	44	nity	nity	NOUN
dti-1327	32	45	for	for	ADP
dti-1327	32	46	the	the	DET
dti-1327	32	47	fr	fr	NOUN
dti-1327	32	48	than	than	ADP
dti-1327	32	49	free	free	ADJ
dti-1327	33	1	fa	fa	INTJ
dti-1327	33	2	(	(	PUNCT
dti-1327	33	3	low	low	ADJ
dti-1327	33	4	and	and	CCONJ
dti-1327	33	5	lee	lee	PROPN
dti-1327	33	6	,	,	PUNCT
dti-1327	33	7	1994	1994	NUM
dti-1327	33	8	)	)	PUNCT
dti-1327	33	9	.	.	PUNCT
dti-1327	34	1	pathways	pathway	NOUN
dti-1327	34	2	that	that	PRON
dti-1327	34	3	can	can	AUX
dti-1327	34	4	break	break	VERB
dti-1327	34	5	down	down	ADP
dti-1327	34	6	or	or	CCONJ
dti-1327	34	7	effl	effl	PROPN
dti-1327	34	8	ux	ux	PROPN
dti-1327	34	9	certain	certain	ADJ
dti-1327	34	10	fa	fa	X
dti-1327	34	11	conjugates	conjugate	NOUN
dti-1327	34	12	are	be	AUX
dti-1327	34	13	inhibited	inhibit	VERB
dti-1327	34	14	by	by	ADP
dti-1327	34	15	the	the	DET
dti-1327	34	16	polymer	polymer	NOUN
dti-1327	34	17	-	-	PUNCT
dti-1327	34	18	fa	fa	NOUN
dti-1327	34	19	conjugate	conjugate	ADJ
dti-1327	34	20	and	and	CCONJ
dti-1327	34	21	renal	renal	ADJ
dti-1327	34	22	retention	retention	NOUN
dti-1327	34	23	times	time	NOUN
dti-1327	34	24	of	of	ADP
dti-1327	34	25	certain	certain	ADJ
dti-1327	34	26	pharmaceuticals	pharmaceutical	NOUN
dti-1327	34	27	have	have	AUX
dti-1327	34	28	been	be	AUX
dti-1327	34	29	improved	improve	VERB
dti-1327	34	30	by	by	ADP
dti-1327	34	31	conjugation	conjugation	NOUN
dti-1327	34	32	to	to	ADP
dti-1327	34	33	peg	peg	NOUN
dti-1327	34	34	units	unit	NOUN
dti-1327	34	35	(	(	PUNCT
dti-1327	34	36	anderson	anderson	PROPN
dti-1327	34	37	et	et	PROPN
dti-1327	34	38	al	al	PROPN
dti-1327	34	39	.	.	PROPN
dti-1327	34	40	2005	2005	NUM
dti-1327	34	41	)	)	PUNCT
dti-1327	34	42	.	.	PUNCT
dti-1327	35	1	hence	hence	ADV
dti-1327	35	2	,	,	PUNCT
dti-1327	35	3	the	the	DET
dti-1327	35	4	use	use	NOUN
dti-1327	35	5	of	of	ADP
dti-1327	35	6	fa	fa	NOUN
dti-1327	35	7	-	-	PUNCT
dti-1327	35	8	peg	peg	NOUN
dti-1327	35	9	conjugates	conjugate	NOUN
dti-1327	35	10	yields	yield	VERB
dti-1327	35	11	synergistic	synergistic	ADJ
dti-1327	35	12	traits	trait	NOUN
dti-1327	35	13	that	that	PRON
dti-1327	35	14	are	be	AUX
dti-1327	35	15	of	of	ADP
dti-1327	35	16	particular	particular	ADJ
dti-1327	35	17	interest	interest	NOUN
dti-1327	35	18	.	.	PUNCT
dti-1327	36	1	conjugation	conjugation	NOUN
dti-1327	36	2	of	of	ADP
dti-1327	36	3	peg	peg	NOUN
dti-1327	36	4	to	to	ADP
dti-1327	36	5	fa	fa	PROPN
dti-1327	36	6	through	through	ADP
dti-1327	36	7	the	the	DET
dti-1327	36	8	glutamate	glutamate	NOUN
dti-1327	36	9	moiety	moiety	NOUN
dti-1327	36	10	produces	produce	VERB
dti-1327	36	11	two	two	NUM
dti-1327	36	12	regioisomer	regioisomer	NOUN
dti-1327	36	13	products	product	NOUN
dti-1327	36	14	at	at	ADP
dti-1327	36	15	the	the	DET
dti-1327	36	16	αand	αand	ADV
dti-1327	36	17	γ	γ	ADJ
dti-1327	36	18	-	-	ADJ
dti-1327	36	19	carboxylic	carboxylic	ADJ
dti-1327	36	20	acid	acid	ADJ
dti-1327	36	21	functional	functional	ADJ
dti-1327	36	22	groups	group	NOUN
dti-1327	36	23	that	that	PRON
dti-1327	36	24	need	need	VERB
dti-1327	36	25	to	to	PART
dti-1327	36	26	be	be	AUX
dti-1327	36	27	separated	separate	VERB
dti-1327	36	28	.	.	PUNCT
dti-1327	37	1	fa	fa	PROPN
dti-1327	37	2	modifi	modifi	PROPN
dti-1327	37	3	ed	ed	PROPN
dti-1327	37	4	at	at	ADP
dti-1327	37	5	the	the	DET
dti-1327	37	6	α	α	PRON
dti-1327	37	7	-	-	ADJ
dti-1327	37	8	carboxylic	carboxylic	ADJ
dti-1327	37	9	acid	acid	NOUN
dti-1327	37	10	loses	lose	VERB
dti-1327	37	11	its	its	PRON
dti-1327	37	12	affi	affi	ADJ
dti-1327	37	13	nity	nity	NOUN
dti-1327	37	14	for	for	ADP
dti-1327	37	15	the	the	DET
dti-1327	37	16	fr	fr	NOUN
dti-1327	37	17	,	,	PUNCT
dti-1327	37	18	making	make	VERB
dti-1327	37	19	it	it	PRON
dti-1327	37	20	unsuitable	unsuitable	ADJ
dti-1327	37	21	as	as	ADP
dti-1327	37	22	a	a	DET
dti-1327	37	23	targeting	target	VERB
dti-1327	37	24	agent	agent	NOUN
dti-1327	37	25	(	(	PUNCT
dti-1327	37	26	yan	yan	PROPN
dti-1327	37	27	and	and	CCONJ
dti-1327	37	28	ratnam	ratnam	PROPN
dti-1327	37	29	,	,	PUNCT
dti-1327	37	30	1995	1995	NUM
dti-1327	37	31	)	)	PUNCT
dti-1327	37	32	.	.	PUNCT
dti-1327	38	1	this	this	DET
dti-1327	38	2	separation	separation	NOUN
dti-1327	38	3	is	be	AUX
dti-1327	38	4	diffi	diffi	ADJ
dti-1327	38	5	cult	cult	NOUN
dti-1327	38	6	when	when	SCONJ
dti-1327	38	7	using	use	VERB
dti-1327	38	8	polydisperse	polydisperse	NOUN
dti-1327	38	9	peg	peg	NOUN
dti-1327	38	10	units	unit	NOUN
dti-1327	38	11	.	.	PUNCT
dti-1327	39	1	such	such	ADJ
dti-1327	39	2	peg	peg	NOUN
dti-1327	39	3	units	unit	NOUN
dti-1327	39	4	are	be	AUX
dti-1327	39	5	typically	typically	ADV
dti-1327	39	6	all	all	PRON
dti-1327	39	7	that	that	PRON
dti-1327	39	8	are	be	AUX
dti-1327	39	9	commercially	commercially	ADV
dti-1327	39	10	available	available	ADJ
dti-1327	39	11	but	but	CCONJ
dti-1327	39	12	are	be	AUX
dti-1327	39	13	approved	approve	VERB
dti-1327	39	14	for	for	ADP
dti-1327	39	15	use	use	NOUN
dti-1327	39	16	by	by	ADP
dti-1327	39	17	the	the	DET
dti-1327	39	18	fda	fda	PROPN
dti-1327	39	19	(	(	PUNCT
dti-1327	39	20	qui	qui	X
dti-1327	39	21	and	and	CCONJ
dti-1327	39	22	bae	bae	PROPN
dti-1327	39	23	,	,	PUNCT
dti-1327	39	24	2006	2006	NUM
dti-1327	39	25	)	)	PUNCT
dti-1327	39	26	.	.	PUNCT
dti-1327	40	1	a	a	DET
dti-1327	40	2	facile	facile	ADJ
dti-1327	40	3	route	route	NOUN
dti-1327	40	4	to	to	ADP
dti-1327	40	5	separation	separation	NOUN
dti-1327	40	6	was	be	AUX
dti-1327	40	7	previously	previously	ADV
dti-1327	40	8	reported	report	VERB
dti-1327	40	9	by	by	ADP
dti-1327	40	10	us	we	PRON
dti-1327	40	11	and	and	CCONJ
dti-1327	40	12	this	this	DET
dti-1327	40	13	route	route	NOUN
dti-1327	40	14	was	be	AUX
dti-1327	40	15	used	use	VERB
dti-1327	40	16	here	here	ADV
dti-1327	40	17	to	to	PART
dti-1327	40	18	allow	allow	VERB
dti-1327	40	19	access	access	NOUN
dti-1327	40	20	to	to	ADP
dti-1327	40	21	pure	pure	ADJ
dti-1327	40	22	γ	γ	PROPN
dti-1327	40	23	-	-	PUNCT
dti-1327	40	24	fa	fa	NOUN
dti-1327	40	25	-	-	PUNCT
dti-1327	40	26	peg	peg	NOUN
dti-1327	40	27	-	-	PUNCT
dti-1327	40	28	nh2	nh2	NOUN
dti-1327	40	29	for	for	ADP
dti-1327	40	30	subsequent	subsequent	ADJ
dti-1327	40	31	conjugation	conjugation	NOUN
dti-1327	40	32	to	to	ADP
dti-1327	40	33	the	the	DET
dti-1327	40	34	gallium-(hdota	gallium-(hdota	NOUN
dti-1327	40	35	)	)	PUNCT
dti-1327	41	1	complex	complex	NOUN
dti-1327	41	2	(	(	PUNCT
dti-1327	41	3	doyle	doyle	PROPN
dti-1327	41	4	et	et	PROPN
dti-1327	41	5	al	al	PROPN
dti-1327	41	6	.	.	PROPN
dti-1327	41	7	2008	2008	NUM
dti-1327	41	8	)	)	PUNCT
dti-1327	41	9	.	.	PUNCT
dti-1327	42	1	in	in	ADP
dti-1327	42	2	vitro	vitro	X
dti-1327	42	3	cytotoxicity	cytotoxicity	NOUN
dti-1327	42	4	assays	assay	NOUN
dti-1327	42	5	were	be	AUX
dti-1327	42	6	conducted	conduct	VERB
dti-1327	42	7	against	against	ADP
dti-1327	42	8	adriamycin	adriamycin	PRON
dti-1327	42	9	resistant	resistant	ADJ
dti-1327	42	10	ovarian	ovarian	ADJ
dti-1327	42	11	cancer	cancer	NOUN
dti-1327	42	12	cell	cell	NOUN
dti-1327	42	13	line	line	NOUN
dti-1327	42	14	(	(	PUNCT
dti-1327	42	15	a2780	a2780	NOUN
dti-1327	42	16	/	/	SYM
dti-1327	42	17	ad	ad	NOUN
dti-1327	42	18	)	)	PUNCT
dti-1327	42	19	,	,	PUNCT
dti-1327	42	20	which	which	PRON
dti-1327	42	21	overexpresses	overexpresse	VERB
dti-1327	42	22	the	the	DET
dti-1327	42	23	fr	fr	NOUN
dti-1327	42	24	,	,	PUNCT
dti-1327	42	25	and	and	CCONJ
dti-1327	42	26	contrasted	contrast	VERB
dti-1327	42	27	against	against	ADP
dti-1327	42	28	a	a	DET
dti-1327	42	29	non	non	ADJ
dti-1327	42	30	-	-	ADJ
dti-1327	42	31	fr	fr	ADJ
dti-1327	42	32	expressing	express	VERB
dti-1327	42	33	chinese	chinese	ADJ
dti-1327	42	34	hamster	hamster	PROPN
dti-1327	42	35	ovary	ovary	NOUN
dti-1327	42	36	(	(	PUNCT
dti-1327	42	37	cho	cho	ADJ
dti-1327	42	38	)	)	PUNCT
dti-1327	42	39	control	control	NOUN
dti-1327	42	40	line	line	NOUN
dti-1327	42	41	.	.	PUNCT
dti-1327	43	1	experimental	experimental	ADJ
dti-1327	43	2	chemicals	chemical	NOUN
dti-1327	43	3	the	the	DET
dti-1327	43	4	following	follow	VERB
dti-1327	43	5	reagents	reagent	NOUN
dti-1327	43	6	were	be	AUX
dti-1327	43	7	purchased	purchase	VERB
dti-1327	43	8	and	and	CCONJ
dti-1327	43	9	used	use	VERB
dti-1327	43	10	without	without	ADP
dti-1327	43	11	further	further	ADJ
dti-1327	43	12	purifi	purifi	ADJ
dti-1327	43	13	cation	cation	NOUN
dti-1327	43	14	:	:	PUNCT
dti-1327	43	15	folic	folic	NOUN
dti-1327	43	16	acid	acid	NOUN
dti-1327	43	17	(	(	PUNCT
dti-1327	43	18	fa	fa	NOUN
dti-1327	43	19	)	)	PUNCT
dti-1327	43	20	(	(	PUNCT
dti-1327	43	21	98	98	NUM
dti-1327	43	22	%	%	NOUN
dti-1327	43	23	,	,	PUNCT
dti-1327	43	24	sigma	sigma	PROPN
dti-1327	43	25	)	)	PUNCT
dti-1327	43	26	,	,	PUNCT
dti-1327	43	27	n	n	CCONJ
dti-1327	43	28	,	,	PUNCT
dti-1327	43	29	n’-dicyclohexylcarbodiimide	n’-dicyclohexylcarbodiimide	ADV
dti-1327	43	30	(	(	PUNCT
dti-1327	43	31	dcc	dcc	PROPN
dti-1327	43	32	,	,	PUNCT
dti-1327	43	33	�	�	PROPN
dti-1327	43	34	99	99	NUM
dti-1327	43	35	%	%	NOUN
dti-1327	43	36	,	,	PUNCT
dti-1327	43	37	fluka	fluka	NOUN
dti-1327	43	38	)	)	PUNCT
dti-1327	43	39	,	,	PUNCT
dti-1327	43	40	polyethylene	polyethylene	NOUN
dti-1327	43	41	glycol	glycol	NOUN
dti-1327	43	42	bis(amine	bis(amine	NOUN
dti-1327	43	43	)	)	PUNCT
dti-1327	43	44	(	(	PUNCT
dti-1327	43	45	peg	peg	NOUN
dti-1327	43	46	,	,	PUNCT
dti-1327	43	47	mw	mw	NOUN
dti-1327	43	48	:	:	PUNCT
dti-1327	43	49	2000	2000	NUM
dti-1327	43	50	)	)	PUNCT
dti-1327	43	51	(	(	PUNCT
dti-1327	43	52	fluka	fluka	NOUN
dti-1327	43	53	)	)	PUNCT
dti-1327	43	54	,	,	PUNCT
dti-1327	43	55	n	n	CCONJ
dti-1327	43	56	-	-	PUNCT
dti-1327	43	57	hydroxysuccinimide	hydroxysuccinimide	NOUN
dti-1327	43	58	(	(	PUNCT
dti-1327	43	59	nhs	nhs	PROPN
dti-1327	43	60	,	,	PUNCT
dti-1327	43	61	�	�	PROPN
dti-1327	43	62	97	97	NUM
dti-1327	43	63	%	%	NOUN
dti-1327	43	64	,	,	PUNCT
dti-1327	43	65	fluka	fluka	NOUN
dti-1327	43	66	)	)	PUNCT
dti-1327	43	67	,	,	PUNCT
dti-1327	43	68	and	and	CCONJ
dti-1327	43	69	1,4,7,10	1,4,7,10	NUM
dti-1327	43	70	-	-	PUNCT
dti-1327	43	71	tetraazacyclododecane	tetraazacyclododecane	NOUN
dti-1327	43	72	-	-	PUNCT
dti-1327	43	73	n	n	CCONJ
dti-1327	43	74	,	,	PUNCT
dti-1327	43	75	n’,n’’,n’’’-tetraacetic	n’,n’’,n’’’-tetraacetic	ADJ
dti-1327	43	76	acid	acid	NOUN
dti-1327	43	77	(	(	PUNCT
dti-1327	43	78	dota	dota	PROPN
dti-1327	43	79	,	,	PUNCT
dti-1327	43	80	98	98	NUM
dti-1327	43	81	%	%	NOUN
dti-1327	43	82	,	,	PUNCT
dti-1327	43	83	strem	strem	ADJ
dti-1327	43	84	chemicals	chemical	NOUN
dti-1327	43	85	)	)	PUNCT
dti-1327	43	86	,	,	PUNCT
dti-1327	43	87	n	n	CCONJ
dti-1327	43	88	-	-	PUNCT
dti-1327	43	89	hydroxysulfosuccinimide	hydroxysulfosuccinimide	NOUN
dti-1327	43	90	sodium	sodium	NOUN
dti-1327	43	91	salt	salt	NOUN
dti-1327	43	92	(	(	PUNCT
dti-1327	43	93	sulfo	sulfo	NOUN
dti-1327	43	94	-	-	PUNCT
dti-1327	43	95	nhs	nhs	PROPN
dti-1327	43	96	,	,	PUNCT
dti-1327	43	97	98.5	98.5	NUM
dti-1327	43	98	%	%	NOUN
dti-1327	43	99	,	,	PUNCT
dti-1327	43	100	fluka	fluka	NOUN
dti-1327	43	101	)	)	PUNCT
dti-1327	43	102	,	,	PUNCT
dti-1327	43	103	1(3	1(3	NUM
dti-1327	43	104	-	-	PUNCT
dti-1327	43	105	dimethylaminopropyl)-3	dimethylaminopropyl)-3	PROPN
dti-1327	43	106	-	-	PUNCT
dti-1327	43	107	ethylcarbodiimide	ethylcarbodiimide	NOUN
dti-1327	43	108	(	(	PUNCT
dti-1327	43	109	edc	edc	PROPN
dti-1327	43	110	,	,	PUNCT
dti-1327	43	111	98	98	NUM
dti-1327	43	112	%	%	NOUN
dti-1327	43	113	,	,	PUNCT
dti-1327	43	114	alfa	alfa	PROPN
dti-1327	43	115	aesar	aesar	PROPN
dti-1327	43	116	)	)	PUNCT
dti-1327	43	117	and	and	CCONJ
dti-1327	43	118	trifl	trifl	VERB
dti-1327	43	119	uoroacetic	uoroacetic	ADJ
dti-1327	43	120	acid	acid	NOUN
dti-1327	43	121	(	(	PUNCT
dti-1327	43	122	99	99	NUM
dti-1327	43	123	%	%	NOUN
dti-1327	43	124	,	,	PUNCT
dti-1327	43	125	aldrich	aldrich	PROPN
dti-1327	43	126	)	)	PUNCT
dti-1327	43	127	.	.	PUNCT
dti-1327	44	1	gacl3	gacl3	PROPN
dti-1327	45	1	(	(	PUNCT
dti-1327	45	2	99.9	99.9	NUM
dti-1327	45	3	%	%	NOUN
dti-1327	45	4	)	)	PUNCT
dti-1327	45	5	was	be	AUX
dti-1327	45	6	purchased	purchase	VERB
dti-1327	45	7	from	from	ADP
dti-1327	45	8	alfa	alfa	NOUN
dti-1327	45	9	aesar	aesar	PROPN
dti-1327	45	10	and	and	CCONJ
dti-1327	45	11	dissolved	dissolve	VERB
dti-1327	45	12	in	in	ADP
dti-1327	45	13	100	100	NUM
dti-1327	45	14	mm	mm	NOUN
dti-1327	45	15	ammonium	ammonium	NOUN
dti-1327	45	16	acetate	acetate	NOUN
dti-1327	45	17	(	(	PUNCT
dti-1327	45	18	ph	ph	NOUN
dti-1327	45	19	4.8	4.8	NUM
dti-1327	45	20	)	)	PUNCT
dti-1327	45	21	to	to	PART
dti-1327	45	22	make	make	VERB
dti-1327	45	23	a	a	DET
dti-1327	45	24	stock	stock	NOUN
dti-1327	45	25	concentration	concentration	NOUN
dti-1327	45	26	of	of	ADP
dti-1327	45	27	1.325	1.325	NUM
dti-1327	45	28	m.	m.	NOUN
dti-1327	45	29	dimethylsulfoxide	dimethylsulfoxide	ADV
dti-1327	45	30	(	(	PUNCT
dti-1327	45	31	dmso	dmso	PROPN
dti-1327	45	32	)	)	PUNCT
dti-1327	45	33	(	(	PUNCT
dti-1327	45	34	min	min	NOUN
dti-1327	45	35	.	.	PROPN
dti-1327	45	36	99.9	99.9	NUM
dti-1327	45	37	%	%	NOUN
dti-1327	45	38	,	,	PUNCT
dti-1327	45	39	sigma	sigma	PROPN
dti-1327	45	40	)	)	PUNCT
dti-1327	45	41	was	be	AUX
dti-1327	45	42	dried	dry	VERB
dti-1327	45	43	by	by	ADP
dti-1327	45	44	running	run	VERB
dti-1327	45	45	the	the	DET
dti-1327	45	46	solvent	solvent	NOUN
dti-1327	45	47	through	through	ADP
dti-1327	45	48	a	a	DET
dti-1327	45	49	column	column	NOUN
dti-1327	45	50	of	of	ADP
dti-1327	45	51	4	4	NUM
dti-1327	45	52	å	å	NOUN
dti-1327	45	53	molecular	molecular	ADJ
dti-1327	45	54	sieves	sieve	NOUN
dti-1327	45	55	(	(	PUNCT
dti-1327	45	56	mallincrodt	mallincrodt	PROPN
dti-1327	45	57	)	)	PUNCT
dti-1327	45	58	dried	dry	VERB
dti-1327	45	59	previously	previously	ADV
dti-1327	45	60	overnight	overnight	ADV
dti-1327	45	61	at	at	ADP
dti-1327	45	62	120	120	NUM
dti-1327	45	63	°	°	NOUN
dti-1327	45	64	c	c	NOUN
dti-1327	45	65	.	.	PUNCT
dti-1327	46	1	solvents	solvent	NOUN
dti-1327	46	2	used	use	VERB
dti-1327	46	3	for	for	ADP
dti-1327	46	4	hplc	hplc	NOUN
dti-1327	46	5	and	and	CCONJ
dti-1327	46	6	growth	growth	NOUN
dti-1327	46	7	media	medium	NOUN
dti-1327	46	8	are	be	AUX
dti-1327	46	9	fi	fi	ADV
dti-1327	46	10	ltered	ltere	VERB
dti-1327	46	11	with	with	ADP
dti-1327	46	12	0.45	0.45	NUM
dti-1327	46	13	µm	µm	ADP
dti-1327	46	14	fi	fi	NOUN
dti-1327	46	15	lter	lter	NOUN
dti-1327	46	16	(	(	PUNCT
dti-1327	46	17	fisher	fisher	PROPN
dti-1327	46	18	)	)	PUNCT
dti-1327	46	19	.	.	PUNCT
dti-1327	47	1	pyridine	pyridine	NOUN
dti-1327	47	2	(	(	PUNCT
dti-1327	47	3	99.9	99.9	NUM
dti-1327	47	4	%	%	NOUN
dti-1327	47	5	)	)	PUNCT
dti-1327	47	6	was	be	AUX
dti-1327	47	7	obtained	obtain	VERB
dti-1327	47	8	from	from	ADP
dti-1327	47	9	fisher	fisher	PROPN
dti-1327	47	10	.	.	PUNCT
dti-1327	48	1	triethylamine	triethylamine	NOUN
dti-1327	48	2	(	(	PUNCT
dti-1327	48	3	99.5	99.5	NUM
dti-1327	48	4	%	%	NOUN
dti-1327	48	5	)	)	PUNCT
dti-1327	48	6	was	be	AUX
dti-1327	48	7	purchased	purchase	VERB
dti-1327	48	8	from	from	ADP
dti-1327	48	9	sigma	sigma	PROPN
dti-1327	48	10	aldrich	aldrich	PROPN
dti-1327	48	11	.	.	PUNCT
dti-1327	49	1	3′-azido-3′deoxythymidine	3′-azido-3′deoxythymidine	NUM
dti-1327	49	2	(	(	PUNCT
dti-1327	49	3	azt	azt	PROPN
dti-1327	49	4	;	;	PUNCT
dti-1327	49	5	used	use	VERB
dti-1327	49	6	as	as	ADP
dti-1327	49	7	internal	internal	ADJ
dti-1327	49	8	control	control	NOUN
dti-1327	49	9	in	in	ADP
dti-1327	49	10	cytotoxicity	cytotoxicity	NOUN
dti-1327	49	11	assays	assay	NOUN
dti-1327	49	12	)	)	PUNCT
dti-1327	49	13	was	be	AUX
dti-1327	49	14	purchased	purchase	VERB
dti-1327	49	15	from	from	ADP
dti-1327	49	16	sigma	sigma	PROPN
dti-1327	49	17	aldrich	aldrich	PROPN
dti-1327	49	18	.	.	PUNCT
dti-1327	50	1	all	all	DET
dti-1327	50	2	other	other	ADJ
dti-1327	50	3	reagents	reagent	NOUN
dti-1327	50	4	and	and	CCONJ
dti-1327	50	5	buffers	buffer	NOUN
dti-1327	50	6	used	use	VERB
dti-1327	50	7	were	be	AUX
dti-1327	50	8	of	of	ADP
dti-1327	50	9	reagent	reagent	ADJ
dti-1327	50	10	grade	grade	NOUN
dti-1327	50	11	or	or	CCONJ
dti-1327	50	12	higher	high	ADJ
dti-1327	50	13	.	.	PUNCT
dti-1327	51	1	ultra	ultra	ADJ
dti-1327	51	2	pure	pure	ADJ
dti-1327	51	3	water	water	NOUN
dti-1327	51	4	(	(	PUNCT
dti-1327	51	5	18.6	18.6	NUM
dti-1327	51	6	mω	mω	NOUN
dti-1327	51	7	)	)	PUNCT
dti-1327	51	8	was	be	AUX
dti-1327	51	9	used	use	VERB
dti-1327	51	10	through	through	ADP
dti-1327	51	11	out	out	ADP
dti-1327	51	12	the	the	DET
dti-1327	51	13	investigation	investigation	NOUN
dti-1327	51	14	.	.	PUNCT
dti-1327	52	1	all	all	DET
dti-1327	52	2	syntheses	synthesis	NOUN
dti-1327	52	3	except	except	SCONJ
dti-1327	52	4	for	for	ADP
dti-1327	52	5	1	1	NUM
dti-1327	52	6	were	be	AUX
dti-1327	52	7	performed	perform	VERB
dti-1327	52	8	in	in	ADP
dti-1327	52	9	a	a	DET
dti-1327	52	10	figure	figure	NOUN
dti-1327	52	11	1	1	NUM
dti-1327	52	12	.	.	PUNCT
dti-1327	52	13	fa	fa	NOUN
dti-1327	53	1	with	with	ADP
dti-1327	53	2	its	its	PRON
dti-1327	53	3	three	three	NUM
dti-1327	53	4	major	major	ADJ
dti-1327	53	5	structural	structural	ADJ
dti-1327	53	6	components	component	NOUN
dti-1327	53	7	including	include	VERB
dti-1327	53	8	the	the	DET
dti-1327	53	9	αand	αand	ADV
dti-1327	53	10	γ	γ	ADJ
dti-1327	53	11	-	-	ADJ
dti-1327	53	12	carboxylic	carboxylic	ADJ
dti-1327	53	13	acid	acid	NOUN
dti-1327	53	14	group	group	NOUN
dti-1327	53	15	of	of	ADP
dti-1327	53	16	the	the	DET
dti-1327	53	17	glutamate	glutamate	NOUN
dti-1327	53	18	moiety	moiety	NOUN
dti-1327	53	19	indicated	indicate	VERB
dti-1327	53	20	.	.	PUNCT
dti-1327	53	21	table	table	NOUN
dti-1327	53	22	1	1	NUM
dti-1327	53	23	.	.	PUNCT
dti-1327	53	24	comparison	comparison	NOUN
dti-1327	53	25	of	of	ADP
dti-1327	53	26	fr	fr	ADJ
dti-1327	53	27	overexpression	overexpression	NOUN
dti-1327	53	28	investigated	investigate	VERB
dti-1327	53	29	in	in	ADP
dti-1327	53	30	different	different	ADJ
dti-1327	53	31	cancer	cancer	NOUN
dti-1327	53	32	tissues	tissue	NOUN
dti-1327	53	33	via	via	ADP
dti-1327	53	34	immunohistochemistry	immunohistochemistry	NOUN
dti-1327	53	35	(	(	PUNCT
dti-1327	53	36	ihc	ihc	PROPN
dti-1327	53	37	)	)	PUNCT
dti-1327	53	38	and	and	CCONJ
dti-1327	53	39	reverse	reverse	ADJ
dti-1327	53	40	transcriptase	transcriptase	NOUN
dti-1327	53	41	—	—	PUNCT
dti-1327	53	42	polymerase	polymerase	NOUN
dti-1327	53	43	chain	chain	NOUN
dti-1327	53	44	techniques	technique	NOUN
dti-1327	53	45	(	(	PUNCT
dti-1327	53	46	rt	rt	NOUN
dti-1327	53	47	-	-	PUNCT
dti-1327	53	48	pcr	pcr	NOUN
dti-1327	53	49	)	)	PUNCT
dti-1327	53	50	(	(	PUNCT
dti-1327	53	51	low	low	ADJ
dti-1327	53	52	and	and	CCONJ
dti-1327	53	53	leamon	leamon	NOUN
dti-1327	53	54	,	,	PUNCT
dti-1327	53	55	2005	2005	NUM
dti-1327	53	56	)	)	PUNCT
dti-1327	53	57	.	.	PUNCT
dti-1327	54	1	tissue	tissue	NOUN
dti-1327	54	2	ihc	ihc	PROPN
dti-1327	54	3	(	(	PUNCT
dti-1327	54	4	%	%	INTJ
dti-1327	54	5	)	)	PUNCT
dti-1327	54	6	rt	rt	ADJ
dti-1327	54	7	-	-	PUNCT
dti-1327	54	8	pcr	pcr	ADJ
dti-1327	54	9	(	(	PUNCT
dti-1327	54	10	%	%	NOUN
dti-1327	54	11	)	)	PUNCT
dti-1327	54	12	ovarian	ovarian	ADJ
dti-1327	54	13	93	93	NUM
dti-1327	54	14	100	100	NUM
dti-1327	54	15	endometrial	endometrial	ADJ
dti-1327	54	16	91	91	NUM
dti-1327	54	17	100	100	NUM
dti-1327	54	18	breast	breast	NOUN
dti-1327	54	19	21	21	NUM
dti-1327	54	20	80	80	NUM
dti-1327	54	21	lung	lung	NOUN
dti-1327	54	22	33	33	NUM
dti-1327	54	23	33	33	NUM
dti-1327	54	24	colorectal	colorectal	ADJ
dti-1327	54	25	22	22	NUM
dti-1327	54	26	20	20	NUM
dti-1327	54	27	kidney	kidney	NOUN
dti-1327	54	28	50	50	NUM
dti-1327	54	29	100	100	NUM
dti-1327	54	30	15	15	NUM
dti-1327	54	31	targeting	target	VERB
dti-1327	54	32	gallium	gallium	NOUN
dti-1327	54	33	to	to	ADP
dti-1327	54	34	cancer	cancer	NOUN
dti-1327	54	35	cells	cell	NOUN
dti-1327	54	36	through	through	ADP
dti-1327	54	37	the	the	DET
dti-1327	54	38	folate	folate	NOUN
dti-1327	54	39	receptor	receptor	NOUN
dti-1327	54	40	drug	drug	NOUN
dti-1327	54	41	target	target	NOUN
dti-1327	54	42	insights	insight	NOUN
dti-1327	54	43	2008:3	2008:3	NUM
dti-1327	54	44	dark	dark	ADJ
dti-1327	54	45	-	-	PUNCT
dti-1327	54	46	room	room	NOUN
dti-1327	54	47	under	under	ADP
dti-1327	54	48	a	a	DET
dti-1327	54	49	15	15	NUM
dti-1327	54	50	w	w	NOUN
dti-1327	54	51	red	red	ADJ
dti-1327	54	52	light	light	NOUN
dti-1327	54	53	.	.	PUNCT
dti-1327	55	1	all	all	DET
dti-1327	55	2	reactions	reaction	NOUN
dti-1327	55	3	were	be	AUX
dti-1327	55	4	conducted	conduct	VERB
dti-1327	55	5	under	under	ADP
dti-1327	55	6	nitrogen	nitrogen	NOUN
dti-1327	55	7	gas	gas	NOUN
dti-1327	55	8	at	at	ADP
dti-1327	55	9	ambient	ambient	ADJ
dti-1327	55	10	conditions	condition	NOUN
dti-1327	55	11	unless	unless	SCONJ
dti-1327	55	12	otherwise	otherwise	ADV
dti-1327	55	13	stated	state	VERB
dti-1327	55	14	with	with	ADP
dti-1327	55	15	sample	sample	NOUN
dti-1327	55	16	transfer	transfer	NOUN
dti-1327	55	17	conducted	conduct	VERB
dti-1327	55	18	by	by	ADP
dti-1327	55	19	cannula	cannula	NOUN
dti-1327	55	20	(	(	PUNCT
dti-1327	55	21	24	24	NUM
dti-1327	55	22	inch	inch	NOUN
dti-1327	55	23	,	,	PUNCT
dti-1327	55	24	16	16	NUM
dti-1327	55	25	gauge	gauge	NOUN
dti-1327	55	26	)	)	PUNCT
dti-1327	55	27	.	.	PUNCT
dti-1327	56	1	physical	physical	ADJ
dti-1327	56	2	measurements	measurement	NOUN
dti-1327	56	3	and	and	CCONJ
dti-1327	56	4	instrumentation	instrumentation	NOUN
dti-1327	56	5	an	an	DET
dti-1327	56	6	agilent	agilent	PROPN
dti-1327	56	7	1100	1100	NUM
dti-1327	56	8	reverse	reverse	NOUN
dti-1327	56	9	phase	phase	NOUN
dti-1327	56	10	high	high	ADJ
dti-1327	56	11	pressure	pressure	NOUN
dti-1327	56	12	liquid	liquid	NOUN
dti-1327	56	13	chromatography	chromatography	NOUN
dti-1327	56	14	(	(	PUNCT
dti-1327	56	15	hplc	hplc	PROPN
dti-1327	56	16	)	)	PUNCT
dti-1327	56	17	with	with	ADP
dti-1327	56	18	manual	manual	ADJ
dti-1327	56	19	injection	injection	NOUN
dti-1327	56	20	and	and	CCONJ
dti-1327	56	21	automated	automate	VERB
dti-1327	56	22	fraction	fraction	NOUN
dti-1327	56	23	collector	collector	NOUN
dti-1327	56	24	was	be	AUX
dti-1327	56	25	fi	fi	NOUN
dti-1327	56	26	tted	tte	VERB
dti-1327	56	27	with	with	ADP
dti-1327	56	28	a	a	DET
dti-1327	56	29	zorbax	zorbax	PROPN
dti-1327	56	30	c18	c18	PROPN
dti-1327	56	31	analytical	analytical	ADJ
dti-1327	56	32	column	column	NOUN
dti-1327	56	33	(	(	PUNCT
dti-1327	56	34	42	42	NUM
dti-1327	56	35	×	×	NOUN
dti-1327	56	36	10	10	NUM
dti-1327	56	37	mm	mm	NOUN
dti-1327	56	38	)	)	PUNCT
dti-1327	56	39	for	for	ADP
dti-1327	56	40	analytical	analytical	ADJ
dti-1327	56	41	trace	trace	NOUN
dti-1327	56	42	analysis	analysis	NOUN
dti-1327	56	43	with	with	ADP
dti-1327	56	44	a	a	DET
dti-1327	56	45	flow	flow	NOUN
dti-1327	56	46	rate	rate	NOUN
dti-1327	56	47	of	of	ADP
dti-1327	56	48	0.7	0.7	NUM
dti-1327	56	49	ml	ml	NOUN
dti-1327	56	50	/	/	SYM
dti-1327	56	51	min	min	PROPN
dti-1327	56	52	.	.	PROPN
dti-1327	56	53	purifi	purifi	PROPN
dti-1327	56	54	cation	cation	NOUN
dti-1327	56	55	was	be	AUX
dti-1327	56	56	achieved	achieve	VERB
dti-1327	56	57	using	use	VERB
dti-1327	56	58	a	a	DET
dti-1327	56	59	c18	c18	NOUN
dti-1327	56	60	(	(	PUNCT
dti-1327	56	61	9.4	9.4	NUM
dti-1327	56	62	×	×	NOUN
dti-1327	56	63	250	250	NUM
dti-1327	56	64	mm	mm	NOUN
dti-1327	56	65	)	)	PUNCT
dti-1327	56	66	semi	semi	ADJ
dti-1327	56	67	-	-	ADJ
dti-1327	56	68	preparative	preparative	ADJ
dti-1327	56	69	column	column	NOUN
dti-1327	56	70	using	use	VERB
dti-1327	56	71	a	a	DET
dti-1327	56	72	fl	fl	NOUN
dti-1327	56	73	ow	ow	INTJ
dti-1327	56	74	rate	rate	NOUN
dti-1327	56	75	of	of	ADP
dti-1327	56	76	2	2	NUM
dti-1327	56	77	ml	ml	NOUN
dti-1327	56	78	/	/	SYM
dti-1327	56	79	min	min	NOUN
dti-1327	56	80	.	.	PROPN
dti-1327	56	81	detection	detection	NOUN
dti-1327	56	82	was	be	AUX
dti-1327	56	83	by	by	ADP
dti-1327	56	84	ultra	ultra	ADJ
dti-1327	56	85	violet	violet	NOUN
dti-1327	56	86	monitoring	monitoring	NOUN
dti-1327	56	87	at	at	ADP
dti-1327	56	88	280	280	NUM
dti-1327	56	89	nm	nm	NOUN
dti-1327	56	90	.	.	PUNCT
dti-1327	57	1	the	the	DET
dti-1327	57	2	linear	linear	PROPN
dti-1327	57	3	gradient	gradient	NOUN
dti-1327	57	4	used	use	VERB
dti-1327	57	5	was	be	AUX
dti-1327	57	6	:	:	PUNCT
dti-1327	57	7	(	(	PUNCT
dti-1327	57	8	1	1	X
dti-1327	57	9	)	)	PUNCT
dti-1327	57	10	90	90	NUM
dti-1327	57	11	%	%	NOUN
dti-1327	57	12	5	5	NUM
dti-1327	57	13	mm	mm	NOUN
dti-1327	57	14	na2hpo4	na2hpo4	PROPN
dti-1327	57	15	(	(	PUNCT
dti-1327	57	16	ph	ph	NOUN
dti-1327	57	17	7.0	7.0	NUM
dti-1327	57	18	)	)	PUNCT
dti-1327	57	19	and	and	CCONJ
dti-1327	57	20	10	10	NUM
dti-1327	57	21	%	%	NOUN
dti-1327	57	22	acetonitrile	acetonitrile	NOUN
dti-1327	57	23	over	over	ADP
dti-1327	57	24	10	10	NUM
dti-1327	57	25	minutes	minute	NOUN
dti-1327	57	26	;	;	PUNCT
dti-1327	57	27	(	(	PUNCT
dti-1327	57	28	2	2	X
dti-1327	57	29	)	)	PUNCT
dti-1327	57	30	40	40	NUM
dti-1327	57	31	%	%	NOUN
dti-1327	57	32	5	5	NUM
dti-1327	57	33	mm	mm	NOUN
dti-1327	57	34	na2hpo4	na2hpo4	PROPN
dti-1327	57	35	and	and	CCONJ
dti-1327	57	36	60	60	NUM
dti-1327	57	37	%	%	NOUN
dti-1327	57	38	acetonitrile	acetonitrile	NOUN
dti-1327	57	39	over	over	ADP
dti-1327	57	40	20	20	NUM
dti-1327	57	41	minutes	minute	NOUN
dti-1327	57	42	.	.	PUNCT
dti-1327	58	1	ion	ion	NOUN
dti-1327	58	2	exchange	exchange	NOUN
dti-1327	58	3	chromatography	chromatography	NOUN
dti-1327	58	4	(	(	PUNCT
dti-1327	58	5	iec	iec	PROPN
dti-1327	58	6	)	)	PUNCT
dti-1327	58	7	was	be	AUX
dti-1327	58	8	conducted	conduct	VERB
dti-1327	58	9	on	on	ADP
dti-1327	58	10	an	an	DET
dti-1327	58	11	akta	akta	NOUN
dti-1327	58	12	prime	prime	NOUN
dti-1327	58	13	plus	plus	CCONJ
dti-1327	58	14	with	with	ADP
dti-1327	58	15	primeview	primeview	VERB
dti-1327	58	16	5.0	5.0	NUM
dti-1327	58	17	software	software	NOUN
dti-1327	58	18	.	.	PUNCT
dti-1327	59	1	the	the	DET
dti-1327	59	2	anx	anx	NOUN
dti-1327	59	3	(	(	PUNCT
dti-1327	59	4	1	1	NUM
dti-1327	59	5	ml	ml	NOUN
dti-1327	59	6	)	)	PUNCT
dti-1327	59	7	and	and	CCONJ
dti-1327	59	8	the	the	DET
dti-1327	59	9	pd10	pd10	PROPN
dti-1327	59	10	sephadex	sephadex	NOUN
dti-1327	59	11	g-25	g-25	NOUN
dti-1327	59	12	m	m	AUX
dti-1327	59	13	desalting	desalt	VERB
dti-1327	59	14	(	(	PUNCT
dti-1327	59	15	10	10	NUM
dti-1327	59	16	ml	ml	NOUN
dti-1327	59	17	)	)	PUNCT
dti-1327	59	18	columns	column	NOUN
dti-1327	59	19	were	be	AUX
dti-1327	59	20	purchased	purchase	VERB
dti-1327	59	21	from	from	ADP
dti-1327	59	22	ge	ge	PROPN
dti-1327	59	23	healthsciences	healthscience	NOUN
dti-1327	59	24	.	.	PUNCT
dti-1327	60	1	1h	1h	NUM
dti-1327	60	2	nuclear	nuclear	PROPN
dti-1327	60	3	magnetic	magnetic	ADJ
dti-1327	60	4	resonance	resonance	NOUN
dti-1327	60	5	(	(	PUNCT
dti-1327	60	6	1h	1h	NUM
dti-1327	60	7	nmr	nmr	NOUN
dti-1327	60	8	)	)	PUNCT
dti-1327	60	9	was	be	AUX
dti-1327	60	10	performed	perform	VERB
dti-1327	60	11	on	on	ADP
dti-1327	60	12	bruker	bruker	PROPN
dti-1327	60	13	avance	avance	PROPN
dti-1327	60	14	dpx	dpx	PROPN
dti-1327	60	15	500	500	NUM
dti-1327	60	16	mhz	mhz	NOUN
dti-1327	60	17	.	.	PUNCT
dti-1327	61	1	a	a	DET
dti-1327	61	2	shimadzu	shimadzu	ADJ
dti-1327	61	3	lcms-2010	lcms-2010	NOUN
dti-1327	61	4	a	a	DET
dti-1327	61	5	mass	mass	NOUN
dti-1327	61	6	spectrometer	spectrometer	NOUN
dti-1327	61	7	and	and	CCONJ
dti-1327	61	8	an	an	DET
dti-1327	61	9	applied	apply	VERB
dti-1327	61	10	biosystems	biosystem	NOUN
dti-1327	61	11	voyager	voyager	NOUN
dti-1327	61	12	-	-	PUNCT
dti-1327	61	13	de	de	X
dti-1327	61	14	linear	linear	NOUN
dti-1327	61	15	matrix	matrix	NOUN
dti-1327	61	16	assisted	assist	VERB
dti-1327	61	17	laser	laser	NOUN
dti-1327	61	18	desorption	desorption	NOUN
dti-1327	61	19	ionization	ionization	NOUN
dti-1327	61	20	—	—	PUNCT
dti-1327	61	21	time	time	NOUN
dti-1327	61	22	of	of	ADP
dti-1327	61	23	flight	flight	NOUN
dti-1327	61	24	mass	mass	NOUN
dti-1327	61	25	spectrometer	spectrometer	NOUN
dti-1327	61	26	(	(	PUNCT
dti-1327	61	27	maldi	maldi	NOUN
dti-1327	61	28	-	-	PUNCT
dti-1327	61	29	tof	tof	PROPN
dti-1327	61	30	)	)	PUNCT
dti-1327	61	31	were	be	AUX
dti-1327	61	32	used	use	VERB
dti-1327	61	33	for	for	ADP
dti-1327	61	34	mass	mass	ADJ
dti-1327	61	35	spectrometry	spectrometry	NOUN
dti-1327	61	36	analysis	analysis	NOUN
dti-1327	61	37	.	.	PUNCT
dti-1327	62	1	infrared	infrared	PROPN
dti-1327	62	2	(	(	PUNCT
dti-1327	62	3	ir	ir	NOUN
dti-1327	62	4	)	)	PUNCT
dti-1327	62	5	analyses	analysis	NOUN
dti-1327	62	6	were	be	AUX
dti-1327	62	7	performed	perform	VERB
dti-1327	62	8	as	as	ADP
dti-1327	62	9	kbr	kbr	PROPN
dti-1327	62	10	pellets	pellet	NOUN
dti-1327	62	11	on	on	ADP
dti-1327	62	12	a	a	DET
dti-1327	62	13	nicolet	nicolet	NOUN
dti-1327	62	14	magna	magna	PROPN
dti-1327	62	15	-	-	PUNCT
dti-1327	62	16	ir	ir	PROPN
dti-1327	62	17	850	850	NUM
dti-1327	62	18	series	series	NOUN
dti-1327	62	19	ii	ii	PROPN
dti-1327	62	20	spectrophotometer	spectrophotometer	PROPN
dti-1327	62	21	.	.	PUNCT
dti-1327	63	1	a	a	DET
dti-1327	63	2	perkin	perkin	PROPN
dti-1327	63	3	elmer	elmer	PROPN
dti-1327	63	4	elan	elan	PROPN
dti-1327	63	5	6100	6100	NUM
dti-1327	63	6	was	be	AUX
dti-1327	63	7	used	use	VERB
dti-1327	63	8	to	to	PART
dti-1327	63	9	conduct	conduct	VERB
dti-1327	63	10	inductively	inductively	ADV
dti-1327	63	11	coupled	couple	VERB
dti-1327	63	12	plasma	plasma	NOUN
dti-1327	63	13	analysis	analysis	NOUN
dti-1327	63	14	(	(	PUNCT
dti-1327	63	15	icp	icp	PROPN
dti-1327	63	16	)	)	PUNCT
dti-1327	63	17	.	.	PUNCT
dti-1327	64	1	centrifugation	centrifugation	NOUN
dti-1327	64	2	was	be	AUX
dti-1327	64	3	performed	perform	VERB
dti-1327	64	4	using	use	VERB
dti-1327	64	5	a	a	DET
dti-1327	64	6	sorvall	sorvall	NOUN
dti-1327	64	7	legend	legend	PROPN
dti-1327	64	8	rt	rt	PROPN
dti-1327	64	9	centrifuge	centrifuge	PROPN
dti-1327	64	10	typically	typically	ADV
dti-1327	64	11	as	as	ADP
dti-1327	64	12	10	10	NUM
dti-1327	64	13	minute	minute	NOUN
dti-1327	64	14	runs	run	NOUN
dti-1327	64	15	at	at	ADP
dti-1327	64	16	4000	4000	NUM
dti-1327	64	17	rpm	rpm	NOUN
dti-1327	64	18	at	at	ADP
dti-1327	64	19	4	4	NUM
dti-1327	64	20	ºc	ºc	NUM
dti-1327	64	21	.	.	PUNCT
dti-1327	65	1	optical	optical	ADJ
dti-1327	65	2	densities	density	NOUN
dti-1327	65	3	were	be	AUX
dti-1327	65	4	measured	measure	VERB
dti-1327	65	5	with	with	ADP
dti-1327	65	6	a	a	DET
dti-1327	65	7	thermo	thermo	NOUN
dti-1327	65	8	multiskan	multiskan	VERB
dti-1327	65	9	ex	ex	PRON
dti-1327	65	10	96	96	NUM
dti-1327	65	11	-	-	PUNCT
dti-1327	65	12	well	well	NOUN
dti-1327	65	13	plate	plate	NOUN
dti-1327	65	14	reader	reader	NOUN
dti-1327	65	15	equipped	equip	VERB
dti-1327	65	16	with	with	ADP
dti-1327	65	17	ascent	ascent	NOUN
dti-1327	65	18	software	software	NOUN
dti-1327	65	19	version	version	NOUN
dti-1327	65	20	2.6	2.6	NUM
dti-1327	65	21	with	with	ADP
dti-1327	65	22	450	450	NUM
dti-1327	65	23	nm	nm	DET
dti-1327	65	24	fi	fi	NOUN
dti-1327	65	25	lter	lter	NOUN
dti-1327	65	26	.	.	PUNCT
dti-1327	66	1	chemical	chemical	ADJ
dti-1327	66	2	synthesis	synthesis	NOUN
dti-1327	66	3	synthesis	synthesis	NOUN
dti-1327	66	4	of	of	ADP
dti-1327	66	5	gahdota	gahdota	NOUN
dti-1327	66	6	(	(	PUNCT
dti-1327	66	7	1	1	NUM
dti-1327	66	8	)	)	PUNCT
dti-1327	66	9	1	1	NUM
dti-1327	66	10	was	be	AUX
dti-1327	66	11	synthesized	synthesize	VERB
dti-1327	66	12	as	as	SCONJ
dti-1327	66	13	reported	report	VERB
dti-1327	66	14	previously	previously	ADV
dti-1327	66	15	by	by	ADP
dti-1327	66	16	doyle	doyle	PROPN
dti-1327	66	17	et	et	PROPN
dti-1327	66	18	al	al	PROPN
dti-1327	66	19	.	.	PUNCT
dti-1327	67	1	(	(	PUNCT
dti-1327	67	2	doyle	doyle	PROPN
dti-1327	67	3	et	et	PROPN
dti-1327	67	4	al	al	PROPN
dti-1327	67	5	.	.	PROPN
dti-1327	67	6	2006	2006	NUM
dti-1327	67	7	)	)	PUNCT
dti-1327	67	8	.	.	PUNCT
dti-1327	68	1	synthesis	synthesis	NOUN
dti-1327	68	2	of	of	ADP
dti-1327	68	3	γ	γ	PROPN
dti-1327	68	4	-	-	PUNCT
dti-1327	68	5	fa	fa	NOUN
dti-1327	68	6	-	-	PUNCT
dti-1327	68	7	peg	peg	NOUN
dti-1327	68	8	-	-	PUNCT
dti-1327	68	9	nh2	nh2	NOUN
dti-1327	68	10	(	(	PUNCT
dti-1327	68	11	γ-2	γ-2	PROPN
dti-1327	68	12	)	)	PUNCT
dti-1327	68	13	fa	fa	NOUN
dti-1327	69	1	(	(	PUNCT
dti-1327	69	2	0.0441	0.0441	NUM
dti-1327	69	3	g	g	NOUN
dti-1327	69	4	,	,	PUNCT
dti-1327	69	5	0.100	0.100	NUM
dti-1327	69	6	mmol	mmol	NOUN
dti-1327	69	7	)	)	PUNCT
dti-1327	69	8	was	be	AUX
dti-1327	69	9	dissolved	dissolve	VERB
dti-1327	69	10	in	in	ADP
dti-1327	69	11	3	3	NUM
dti-1327	69	12	ml	ml	NOUN
dti-1327	69	13	of	of	ADP
dti-1327	69	14	dry	dry	ADJ
dti-1327	69	15	dmso	dmso	NOUN
dti-1327	69	16	.	.	PUNCT
dti-1327	70	1	to	to	ADP
dti-1327	70	2	this	this	DET
dti-1327	70	3	solution	solution	NOUN
dti-1327	70	4	,	,	PUNCT
dti-1327	70	5	0.0127	0.0127	NUM
dti-1327	70	6	g	g	NOUN
dti-1327	70	7	of	of	ADP
dti-1327	70	8	nhs	nhs	PROPN
dti-1327	70	9	(	(	PUNCT
dti-1327	70	10	0.110	0.110	NUM
dti-1327	70	11	mmol	mmol	NOUN
dti-1327	70	12	)	)	PUNCT
dti-1327	70	13	was	be	AUX
dti-1327	70	14	added	add	VERB
dti-1327	70	15	.	.	PUNCT
dti-1327	71	1	the	the	DET
dti-1327	71	2	mixture	mixture	NOUN
dti-1327	71	3	was	be	AUX
dti-1327	71	4	stirred	stir	VERB
dti-1327	71	5	for	for	ADP
dti-1327	71	6	5	5	NUM
dti-1327	71	7	minutes	minute	NOUN
dti-1327	71	8	after	after	ADP
dti-1327	71	9	which	which	PRON
dti-1327	71	10	0.023	0.023	NUM
dti-1327	71	11	g	g	NOUN
dti-1327	71	12	(	(	PUNCT
dti-1327	71	13	0.110	0.110	NUM
dti-1327	71	14	mmol	mmol	NOUN
dti-1327	71	15	)	)	PUNCT
dti-1327	71	16	of	of	ADP
dti-1327	71	17	dcc	dcc	PROPN
dti-1327	71	18	was	be	AUX
dti-1327	71	19	added	add	VERB
dti-1327	71	20	.	.	PUNCT
dti-1327	72	1	the	the	DET
dti-1327	72	2	solution	solution	NOUN
dti-1327	72	3	was	be	AUX
dti-1327	72	4	then	then	ADV
dti-1327	72	5	stirred	stir	VERB
dti-1327	72	6	overnight	overnight	ADV
dti-1327	72	7	.	.	PUNCT
dti-1327	73	1	the	the	DET
dti-1327	73	2	activated	activate	VERB
dti-1327	73	3	fa	fa	PROPN
dti-1327	73	4	was	be	AUX
dti-1327	73	5	fi	fi	NOUN
dti-1327	73	6	ltered	ltere	VERB
dti-1327	73	7	through	through	ADP
dti-1327	73	8	a	a	DET
dti-1327	73	9	0.45	0.45	NUM
dti-1327	73	10	µm	µm	ADP
dti-1327	73	11	fi	fi	NOUN
dti-1327	73	12	lter	lter	NOUN
dti-1327	73	13	to	to	PART
dti-1327	73	14	remove	remove	VERB
dti-1327	73	15	the	the	DET
dti-1327	73	16	dicyclohexylurea	dicyclohexylurea	NOUN
dti-1327	73	17	side	side	NOUN
dti-1327	73	18	product	product	NOUN
dti-1327	73	19	.	.	PUNCT
dti-1327	74	1	the	the	DET
dti-1327	74	2	fa	fa	PROPN
dti-1327	74	3	-	-	PUNCT
dti-1327	74	4	nhs	nhs	NOUN
dti-1327	74	5	solution	solution	NOUN
dti-1327	74	6	was	be	AUX
dti-1327	74	7	then	then	ADV
dti-1327	74	8	added	add	VERB
dti-1327	74	9	dropwise	dropwise	NOUN
dti-1327	74	10	to	to	PART
dti-1327	74	11	peg2000	peg2000	VERB
dti-1327	74	12	(	(	PUNCT
dti-1327	74	13	0.200	0.200	NUM
dti-1327	74	14	g	g	NOUN
dti-1327	74	15	,	,	PUNCT
dti-1327	74	16	0.100	0.100	NUM
dti-1327	74	17	mmol	mmol	NOUN
dti-1327	74	18	)	)	PUNCT
dti-1327	74	19	previously	previously	ADV
dti-1327	74	20	dissolved	dissolve	VERB
dti-1327	74	21	in	in	ADP
dti-1327	74	22	3	3	NUM
dti-1327	74	23	ml	ml	NOUN
dti-1327	74	24	dmso	dmso	NOUN
dti-1327	74	25	.	.	PUNCT
dti-1327	74	26	100	100	NUM
dti-1327	74	27	µl	µl	NOUN
dti-1327	74	28	of	of	ADP
dti-1327	74	29	pyridine	pyridine	NOUN
dti-1327	74	30	was	be	AUX
dti-1327	74	31	then	then	ADV
dti-1327	74	32	added	add	VERB
dti-1327	74	33	and	and	CCONJ
dti-1327	74	34	the	the	DET
dti-1327	74	35	reaction	reaction	NOUN
dti-1327	74	36	stirred	stir	VERB
dti-1327	74	37	overnight	overnight	ADV
dti-1327	74	38	.	.	PUNCT
dti-1327	75	1	approximately	approximately	ADV
dti-1327	75	2	25	25	NUM
dti-1327	75	3	ml	ml	NOUN
dti-1327	75	4	of	of	ADP
dti-1327	75	5	chilled	chilled	ADJ
dti-1327	75	6	isopropanol	isopropanol	NOUN
dti-1327	75	7	(	(	PUNCT
dti-1327	75	8	−78	−78	PROPN
dti-1327	75	9	°	°	NOUN
dti-1327	75	10	c	c	NOUN
dti-1327	75	11	)	)	PUNCT
dti-1327	75	12	was	be	AUX
dti-1327	75	13	added	add	VERB
dti-1327	75	14	forming	form	VERB
dti-1327	75	15	a	a	DET
dti-1327	75	16	light	light	ADJ
dti-1327	75	17	yellow	yellow	ADJ
dti-1327	75	18	precipitate	precipitate	NOUN
dti-1327	75	19	.	.	PUNCT
dti-1327	76	1	the	the	DET
dti-1327	76	2	precipitate	precipitate	NOUN
dti-1327	76	3	was	be	AUX
dti-1327	76	4	obtained	obtain	VERB
dti-1327	76	5	via	via	ADP
dti-1327	76	6	centrifugation	centrifugation	NOUN
dti-1327	76	7	.	.	PUNCT
dti-1327	77	1	the	the	DET
dti-1327	77	2	γand	γand	NOUN
dti-1327	77	3	α	α	NOUN
dti-1327	77	4	-	-	PUNCT
dti-1327	77	5	isomers	isomer	NOUN
dti-1327	77	6	of	of	ADP
dti-1327	77	7	2	2	NUM
dti-1327	77	8	were	be	AUX
dti-1327	77	9	separated	separate	VERB
dti-1327	77	10	via	via	ADP
dti-1327	77	11	iec	iec	NOUN
dti-1327	77	12	using	use	VERB
dti-1327	77	13	the	the	DET
dti-1327	77	14	following	follow	VERB
dti-1327	77	15	method	method	NOUN
dti-1327	78	1	[	[	X
dti-1327	78	2	doyle	doyle	NOUN
dti-1327	78	3	et	et	PROPN
dti-1327	78	4	al	al	PROPN
dti-1327	78	5	.	.	PROPN
dti-1327	78	6	2008	2008	NUM
dti-1327	78	7	)	)	PUNCT
dti-1327	78	8	.	.	PUNCT
dti-1327	79	1	2	2	NUM
dti-1327	79	2	was	be	AUX
dti-1327	79	3	redissolved	redissolve	VERB
dti-1327	79	4	in	in	ADP
dti-1327	79	5	water	water	NOUN
dti-1327	79	6	to	to	PART
dti-1327	79	7	give	give	VERB
dti-1327	79	8	a	a	DET
dti-1327	79	9	[	[	X
dti-1327	79	10	20	20	NUM
dti-1327	79	11	mg	mg	NUM
dti-1327	79	12	/	/	SYM
dti-1327	79	13	ml	ml	NOUN
dti-1327	79	14	]	]	X
dti-1327	79	15	concentration	concentration	NOUN
dti-1327	79	16	.	.	PUNCT
dti-1327	80	1	this	this	DET
dti-1327	80	2	solution	solution	NOUN
dti-1327	80	3	was	be	AUX
dti-1327	80	4	desalted	desalt	VERB
dti-1327	80	5	using	use	VERB
dti-1327	80	6	a	a	DET
dti-1327	80	7	10	10	NUM
dti-1327	80	8	ml	ml	NOUN
dti-1327	80	9	sephadex	sephadex	NOUN
dti-1327	80	10	pd10	pd10	PROPN
dti-1327	80	11	desalting	desalt	VERB
dti-1327	80	12	column	column	NOUN
dti-1327	80	13	eluting	elute	VERB
dti-1327	80	14	the	the	DET
dti-1327	80	15	product	product	NOUN
dti-1327	80	16	in	in	ADP
dti-1327	80	17	water	water	NOUN
dti-1327	80	18	.	.	PUNCT
dti-1327	81	1	500	500	NUM
dti-1327	81	2	µl	µl	NOUN
dti-1327	81	3	of	of	ADP
dti-1327	81	4	this	this	DET
dti-1327	81	5	solution	solution	NOUN
dti-1327	81	6	was	be	AUX
dti-1327	81	7	injected	inject	VERB
dti-1327	81	8	into	into	ADP
dti-1327	81	9	a	a	DET
dti-1327	81	10	1	1	NUM
dti-1327	81	11	ml	ml	NOUN
dti-1327	81	12	anx	anx	ADJ
dti-1327	81	13	weak	weak	ADJ
dti-1327	81	14	anion	anion	NOUN
dti-1327	81	15	exchange	exchange	NOUN
dti-1327	81	16	column	column	NOUN
dti-1327	81	17	.	.	PUNCT
dti-1327	82	1	the	the	DET
dti-1327	82	2	fl	fl	PROPN
dti-1327	82	3	ow	ow	INTJ
dti-1327	82	4	rate	rate	NOUN
dti-1327	82	5	was	be	AUX
dti-1327	82	6	set	set	VERB
dti-1327	82	7	at	at	ADP
dti-1327	82	8	0.1	0.1	NUM
dti-1327	82	9	ml	ml	NOUN
dti-1327	82	10	/	/	SYM
dti-1327	82	11	min	min	NOUN
dti-1327	82	12	.	.	PUNCT
dti-1327	83	1	the	the	DET
dti-1327	83	2	column	column	NOUN
dti-1327	83	3	was	be	AUX
dti-1327	83	4	then	then	ADV
dti-1327	83	5	washed	wash	VERB
dti-1327	83	6	with	with	ADP
dti-1327	83	7	figure	figure	NOUN
dti-1327	83	8	2	2	NUM
dti-1327	83	9	.	.	PUNCT
dti-1327	83	10	crystal	crystal	NOUN
dti-1327	83	11	structure	structure	NOUN
dti-1327	83	12	of	of	ADP
dti-1327	83	13	ga(hdota	ga(hdota	PROPN
dti-1327	83	14	)	)	PUNCT
dti-1327	84	1	[	[	X
dti-1327	84	2	20	20	NUM
dti-1327	84	3	]	]	PUNCT
dti-1327	84	4	.	.	PUNCT
dti-1327	85	1	16	16	NUM
dti-1327	85	2	viola	viola	PROPN
dti-1327	85	3	-	-	PUNCT
dti-1327	85	4	villegas	villegas	PROPN
dti-1327	85	5	et	et	PROPN
dti-1327	85	6	al	al	PROPN
dti-1327	85	7	drug	drug	PROPN
dti-1327	85	8	target	target	NOUN
dti-1327	85	9	insights	insight	NOUN
dti-1327	85	10	2008:3	2008:3	NUM
dti-1327	85	11	5	5	NUM
dti-1327	85	12	column	column	NOUN
dti-1327	85	13	volumes	volume	NOUN
dti-1327	85	14	of	of	ADP
dti-1327	85	15	water	water	NOUN
dti-1327	85	16	.	.	PUNCT
dti-1327	86	1	after	after	SCONJ
dti-1327	86	2	the	the	DET
dti-1327	86	3	fi	fi	NOUN
dti-1327	86	4	rst	rst	PROPN
dti-1327	86	5	peak	peak	NOUN
dti-1327	86	6	was	be	AUX
dti-1327	86	7	eluted	elute	VERB
dti-1327	86	8	,	,	PUNCT
dti-1327	86	9	the	the	DET
dti-1327	86	10	column	column	NOUN
dti-1327	86	11	was	be	AUX
dti-1327	86	12	then	then	ADV
dti-1327	86	13	washed	wash	VERB
dti-1327	86	14	following	follow	VERB
dti-1327	86	15	a	a	DET
dti-1327	86	16	gradient	gradient	NOUN
dti-1327	86	17	(	(	PUNCT
dti-1327	86	18	solvent	solvent	NOUN
dti-1327	86	19	a	a	PRON
dti-1327	86	20	,	,	PUNCT
dti-1327	86	21	water	water	NOUN
dti-1327	86	22	;	;	PUNCT
dti-1327	87	1	solvent	solvent	PROPN
dti-1327	87	2	b	b	PROPN
dti-1327	87	3	,	,	PUNCT
dti-1327	87	4	100	100	NUM
dti-1327	87	5	mm	mm	NOUN
dti-1327	87	6	ammonium	ammonium	NOUN
dti-1327	87	7	acetate	acetate	NOUN
dti-1327	87	8	,	,	PUNCT
dti-1327	87	9	ph	ph	NOUN
dti-1327	87	10	10	10	NUM
dti-1327	87	11	)	)	PUNCT
dti-1327	87	12	of	of	ADP
dti-1327	87	13	10	10	NUM
dti-1327	87	14	%	%	NOUN
dti-1327	87	15	b	b	NOUN
dti-1327	87	16	for	for	ADP
dti-1327	87	17	17	17	NUM
dti-1327	87	18	column	column	NOUN
dti-1327	87	19	volumes	volume	NOUN
dti-1327	87	20	,	,	PUNCT
dti-1327	87	21	50	50	NUM
dti-1327	87	22	%	%	NOUN
dti-1327	87	23	b	b	NOUN
dti-1327	87	24	for	for	ADP
dti-1327	87	25	17	17	NUM
dti-1327	87	26	column	column	NOUN
dti-1327	87	27	volumes	volume	NOUN
dti-1327	87	28	,	,	PUNCT
dti-1327	87	29	80	80	NUM
dti-1327	87	30	%	%	NOUN
dti-1327	87	31	b	b	NOUN
dti-1327	87	32	for	for	ADP
dti-1327	87	33	15	15	NUM
dti-1327	87	34	column	column	NOUN
dti-1327	87	35	volumes	volume	NOUN
dti-1327	87	36	.	.	PUNCT
dti-1327	88	1	a	a	DET
dti-1327	88	2	column	column	NOUN
dti-1327	88	3	volume	volume	NOUN
dti-1327	88	4	of	of	ADP
dti-1327	88	5	5	5	NUM
dti-1327	88	6	ml	ml	NOUN
dti-1327	88	7	of	of	ADP
dti-1327	88	8	0.5	0.5	NUM
dti-1327	88	9	m	m	PROPN
dti-1327	88	10	nacl	nacl	NOUN
dti-1327	88	11	was	be	AUX
dti-1327	88	12	used	use	VERB
dti-1327	88	13	to	to	ADP
dti-1327	88	14	fl	fl	PROPN
dti-1327	88	15	ush	ush	PROPN
dti-1327	88	16	the	the	DET
dti-1327	88	17	column	column	NOUN
dti-1327	88	18	.	.	PUNCT
dti-1327	89	1	1h	1h	NUM
dti-1327	89	2	nmr	nmr	NOUN
dti-1327	89	3	(	(	PUNCT
dti-1327	89	4	d2o	d2o	PROPN
dti-1327	89	5	):	):	PUNCT
dti-1327	89	6	δ	δ	PROPN
dti-1327	89	7	8.62	8.62	NUM
dti-1327	89	8	(	(	PUNCT
dti-1327	89	9	s	s	PROPN
dti-1327	89	10	,	,	PUNCT
dti-1327	89	11	1h	1h	NUM
dti-1327	89	12	)	)	PUNCT
dti-1327	89	13	,	,	PUNCT
dti-1327	89	14	δ	δ	PROPN
dti-1327	89	15	7.83	7.83	NUM
dti-1327	89	16	(	(	PUNCT
dti-1327	89	17	t	t	PROPN
dti-1327	89	18	,	,	PUNCT
dti-1327	89	19	2h	2h	NUM
dti-1327	89	20	)	)	PUNCT
dti-1327	89	21	,	,	PUNCT
dti-1327	89	22	δ	δ	PROPN
dti-1327	89	23	6.63	6.63	NUM
dti-1327	89	24	(	(	PUNCT
dti-1327	89	25	d	d	PROPN
dti-1327	89	26	,	,	PUNCT
dti-1327	89	27	2h	2h	NUM
dti-1327	89	28	)	)	PUNCT
dti-1327	89	29	,	,	PUNCT
dti-1327	89	30	δ	δ	PROPN
dti-1327	89	31	3.50–3.80	3.50–3.80	NUM
dti-1327	89	32	(	(	PUNCT
dti-1327	89	33	m	m	PROPN
dti-1327	89	34	,	,	PUNCT
dti-1327	89	35	peg	peg	NOUN
dti-1327	89	36	)	)	PUNCT
dti-1327	89	37	.	.	PUNCT
dti-1327	90	1	yield	yield	NOUN
dti-1327	90	2	:	:	PUNCT
dti-1327	90	3	60	60	NUM
dti-1327	90	4	%	%	NOUN
dti-1327	90	5	based	base	VERB
dti-1327	90	6	on	on	ADP
dti-1327	90	7	peg	peg	NOUN
dti-1327	90	8	.	.	PUNCT
dti-1327	91	1	only	only	ADV
dti-1327	91	2	the	the	DET
dti-1327	91	3	isolated	isolated	ADJ
dti-1327	91	4	γ	γ	X
dti-1327	91	5	-isomer	-isomer	X
dti-1327	91	6	(	(	PUNCT
dti-1327	91	7	γ	γ	NOUN
dti-1327	91	8	-2	-2	NUM
dti-1327	91	9	)	)	PUNCT
dti-1327	91	10	was	be	AUX
dti-1327	91	11	used	use	VERB
dti-1327	91	12	for	for	ADP
dti-1327	91	13	subsequent	subsequent	ADJ
dti-1327	91	14	coupling	coupling	NOUN
dti-1327	91	15	.	.	PUNCT
dti-1327	92	1	synthesis	synthesis	NOUN
dti-1327	92	2	of	of	ADP
dti-1327	92	3	γ	γ	X
dti-1327	92	4	-	-	PUNCT
dti-1327	92	5	fa	fa	NOUN
dti-1327	92	6	-	-	PUNCT
dti-1327	92	7	peg	peg	NOUN
dti-1327	92	8	-	-	PUNCT
dti-1327	92	9	h3dota	h3dota	NOUN
dti-1327	92	10	(	(	PUNCT
dti-1327	92	11	γ-3	γ-3	PROPN
dti-1327	92	12	)	)	PUNCT
dti-1327	92	13	the	the	DET
dti-1327	92	14	sulfo	sulfo	NOUN
dti-1327	92	15	-	-	PUNCT
dti-1327	92	16	succinamide	succinamide	NOUN
dti-1327	92	17	ester	ester	NOUN
dti-1327	92	18	of	of	ADP
dti-1327	92	19	dota	dota	PROPN
dti-1327	92	20	was	be	AUX
dti-1327	92	21	prepared	prepare	VERB
dti-1327	92	22	by	by	ADP
dti-1327	92	23	activating	activate	VERB
dti-1327	92	24	0.121	0.121	NUM
dti-1327	92	25	g	g	NOUN
dti-1327	92	26	(	(	PUNCT
dti-1327	92	27	0.300	0.300	NUM
dti-1327	92	28	mmol	mmol	NOUN
dti-1327	92	29	)	)	PUNCT
dti-1327	92	30	of	of	ADP
dti-1327	92	31	the	the	DET
dti-1327	92	32	ligand	ligand	NOUN
dti-1327	92	33	with	with	ADP
dti-1327	92	34	26.5	26.5	NUM
dti-1327	92	35	µl	µl	ADP
dti-1327	92	36	(	(	PUNCT
dti-1327	92	37	0.150	0.150	NUM
dti-1327	92	38	mmol	mmol	NOUN
dti-1327	92	39	)	)	PUNCT
dti-1327	92	40	edc	edc	PROPN
dti-1327	92	41	and	and	CCONJ
dti-1327	92	42	0.0260	0.0260	NUM
dti-1327	92	43	g	g	PROPN
dti-1327	92	44	(	(	PUNCT
dti-1327	92	45	0.120	0.120	NUM
dti-1327	92	46	mmol	mmol	NOUN
dti-1327	92	47	)	)	PUNCT
dti-1327	92	48	sulfo	sulfo	NOUN
dti-1327	92	49	-	-	PUNCT
dti-1327	92	50	nhs	nhs	NOUN
dti-1327	92	51	in	in	ADP
dti-1327	92	52	2	2	NUM
dti-1327	92	53	ml	ml	NOUN
dti-1327	92	54	water	water	NOUN
dti-1327	92	55	.	.	PUNCT
dti-1327	93	1	γ-2	γ-2	PROPN
dti-1327	93	2	(	(	PUNCT
dti-1327	93	3	0.0726	0.0726	NUM
dti-1327	93	4	g	g	NOUN
dti-1327	93	5	,	,	PUNCT
dti-1327	93	6	0.03	0.03	NUM
dti-1327	93	7	mmol	mmol	NOUN
dti-1327	93	8	)	)	PUNCT
dti-1327	93	9	was	be	AUX
dti-1327	93	10	dissolved	dissolve	VERB
dti-1327	93	11	in	in	ADP
dti-1327	93	12	2	2	NUM
dti-1327	93	13	ml	ml	NOUN
dti-1327	93	14	water	water	NOUN
dti-1327	93	15	and	and	CCONJ
dti-1327	93	16	cooled	cool	VERB
dti-1327	93	17	to	to	ADP
dti-1327	93	18	4	4	NUM
dti-1327	93	19	°	°	NOUN
dti-1327	93	20	c	c	NOUN
dti-1327	93	21	.	.	PUNCT
dti-1327	94	1	to	to	ADP
dti-1327	94	2	the	the	DET
dti-1327	94	3	dota	dota	PROPN
dti-1327	94	4	solution	solution	NOUN
dti-1327	94	5	,	,	PUNCT
dti-1327	94	6	γ-2	γ-2	PROPN
dti-1327	94	7	was	be	AUX
dti-1327	94	8	added	add	VERB
dti-1327	94	9	dropwise	dropwise	NOUN
dti-1327	94	10	and	and	CCONJ
dti-1327	94	11	the	the	DET
dti-1327	94	12	ph	ph	NOUN
dti-1327	94	13	was	be	AUX
dti-1327	94	14	adjusted	adjust	VERB
dti-1327	94	15	to	to	ADP
dti-1327	94	16	8.5	8.5	NUM
dti-1327	94	17	.	.	PUNCT
dti-1327	95	1	the	the	DET
dti-1327	95	2	reaction	reaction	NOUN
dti-1327	95	3	was	be	AUX
dti-1327	95	4	left	leave	VERB
dti-1327	95	5	to	to	PART
dti-1327	95	6	stand	stand	VERB
dti-1327	95	7	overnight	overnight	ADV
dti-1327	95	8	.	.	PUNCT
dti-1327	96	1	γ-3	γ-3	PROPN
dti-1327	96	2	was	be	AUX
dti-1327	96	3	obtained	obtain	VERB
dti-1327	96	4	via	via	ADP
dti-1327	96	5	hplc	hplc	NOUN
dti-1327	96	6	with	with	ADP
dti-1327	96	7	a	a	DET
dti-1327	96	8	retention	retention	NOUN
dti-1327	96	9	time	time	NOUN
dti-1327	96	10	,	,	PUNCT
dti-1327	96	11	of	of	ADP
dti-1327	96	12	tr	tr	NOUN
dti-1327	96	13	=	=	NOUN
dti-1327	96	14	20.4	20.4	NUM
dti-1327	96	15	minutes	minute	NOUN
dti-1327	96	16	.	.	PUNCT
dti-1327	97	1	1h	1h	NUM
dti-1327	97	2	nmr	nmr	NOUN
dti-1327	97	3	(	(	PUNCT
dti-1327	97	4	d2o	d2o	PROPN
dti-1327	97	5	):	):	PUNCT
dti-1327	97	6	δ	δ	PROPN
dti-1327	97	7	8.76	8.76	NUM
dti-1327	97	8	(	(	PUNCT
dti-1327	97	9	s	s	PROPN
dti-1327	97	10	,	,	PUNCT
dti-1327	97	11	1h	1h	NUM
dti-1327	97	12	)	)	PUNCT
dti-1327	97	13	,	,	PUNCT
dti-1327	97	14	δ	δ	PROPN
dti-1327	97	15	7.62	7.62	NUM
dti-1327	97	16	(	(	PUNCT
dti-1327	97	17	d	d	PROPN
dti-1327	97	18	,	,	PUNCT
dti-1327	97	19	2h	2h	NUM
dti-1327	97	20	)	)	PUNCT
dti-1327	97	21	,	,	PUNCT
dti-1327	97	22	δ	δ	PROPN
dti-1327	97	23	6.73	6.73	NUM
dti-1327	97	24	(	(	PUNCT
dti-1327	97	25	d	d	PROPN
dti-1327	97	26	,	,	PUNCT
dti-1327	97	27	2h	2h	NUM
dti-1327	97	28	)	)	PUNCT
dti-1327	97	29	,	,	PUNCT
dti-1327	97	30	δ	δ	PROPN
dti-1327	97	31	4.61	4.61	NUM
dti-1327	97	32	(	(	PUNCT
dti-1327	97	33	s	s	PROPN
dti-1327	97	34	,	,	PUNCT
dti-1327	97	35	2h	2h	NUM
dti-1327	97	36	)	)	PUNCT
dti-1327	97	37	,	,	PUNCT
dti-1327	97	38	δ	δ	PROPN
dti-1327	97	39	4.48	4.48	NUM
dti-1327	97	40	(	(	PUNCT
dti-1327	97	41	m	m	PROPN
dti-1327	97	42	,	,	PUNCT
dti-1327	97	43	2h	2h	NUM
dti-1327	97	44	)	)	PUNCT
dti-1327	97	45	,	,	PUNCT
dti-1327	97	46	δ	δ	PROPN
dti-1327	97	47	3.90	3.90	NUM
dti-1327	97	48	–	–	PUNCT
dti-1327	97	49	3.29	3.29	NUM
dti-1327	97	50	(	(	PUNCT
dti-1327	97	51	m	m	PROPN
dti-1327	97	52	,	,	PUNCT
dti-1327	97	53	peg	peg	NOUN
dti-1327	97	54	)	)	PUNCT
dti-1327	97	55	,	,	PUNCT
dti-1327	97	56	δ	δ	PROPN
dti-1327	97	57	2.87	2.87	NUM
dti-1327	97	58	(	(	PUNCT
dti-1327	97	59	d	d	NOUN
dti-1327	97	60	,	,	PUNCT
dti-1327	97	61	2h	2h	NUM
dti-1327	97	62	)	)	PUNCT
dti-1327	97	63	.	.	PUNCT
dti-1327	98	1	yield	yield	NOUN
dti-1327	98	2	:	:	PUNCT
dti-1327	98	3	64.4	64.4	NUM
dti-1327	98	4	%	%	NOUN
dti-1327	98	5	based	base	VERB
dti-1327	98	6	on	on	ADP
dti-1327	98	7	γ-2	γ-2	NOUN
dti-1327	98	8	.	.	PUNCT
dti-1327	99	1	synthesis	synthesis	NOUN
dti-1327	99	2	of	of	ADP
dti-1327	99	3	γ	γ	PROPN
dti-1327	99	4	-	-	PUNCT
dti-1327	99	5	fa	fa	NOUN
dti-1327	99	6	-	-	PUNCT
dti-1327	99	7	peg	peg	NOUN
dti-1327	99	8	-	-	PUNCT
dti-1327	99	9	ga(hdota	ga(hdota	NOUN
dti-1327	99	10	)	)	PUNCT
dti-1327	99	11	(	(	PUNCT
dti-1327	99	12	γ-4	γ-4	ADV
dti-1327	99	13	)	)	PUNCT
dti-1327	99	14	1	1	NUM
dti-1327	99	15	(	(	PUNCT
dti-1327	99	16	3.42	3.42	NUM
dti-1327	99	17	mg	mg	PROPN
dti-1327	99	18	,	,	PUNCT
dti-1327	99	19	0.00726	0.00726	NUM
dti-1327	99	20	mmol	mmol	NOUN
dti-1327	99	21	)	)	PUNCT
dti-1327	99	22	was	be	AUX
dti-1327	99	23	dissolved	dissolve	VERB
dti-1327	99	24	in	in	ADP
dti-1327	99	25	1	1	NUM
dti-1327	99	26	ml	ml	NOUN
dti-1327	99	27	of	of	ADP
dti-1327	99	28	20:80	20:80	NUM
dti-1327	99	29	water	water	NOUN
dti-1327	99	30	:	:	PUNCT
dti-1327	99	31	dmso	dmso	ADJ
dti-1327	99	32	solution	solution	NOUN
dti-1327	99	33	.	.	PUNCT
dti-1327	100	1	a	a	DET
dti-1327	100	2	volume	volume	NOUN
dti-1327	100	3	of	of	ADP
dti-1327	100	4	1	1	NUM
dti-1327	100	5	ml	ml	X
dti-1327	100	6	containing	contain	VERB
dti-1327	100	7	dissolved	dissolve	VERB
dti-1327	100	8	nhs	nhs	NOUN
dti-1327	100	9	(	(	PUNCT
dti-1327	100	10	0.800	0.800	NUM
dti-1327	100	11	mg	mg	PROPN
dti-1327	100	12	,	,	PUNCT
dti-1327	100	13	0.00695	0.00695	NUM
dti-1327	100	14	mmol	mmol	NOUN
dti-1327	100	15	)	)	PUNCT
dti-1327	100	16	and	and	CCONJ
dti-1327	100	17	dcc	dcc	PROPN
dti-1327	100	18	(	(	PUNCT
dti-1327	100	19	1.5	1.5	NUM
dti-1327	100	20	mg	mg	PROPN
dti-1327	100	21	,	,	PUNCT
dti-1327	100	22	0.00727	0.00727	NUM
dti-1327	100	23	mmol	mmol	NOUN
dti-1327	100	24	)	)	PUNCT
dti-1327	100	25	was	be	AUX
dti-1327	100	26	added	add	VERB
dti-1327	100	27	to	to	ADP
dti-1327	100	28	the	the	DET
dti-1327	100	29	solution	solution	NOUN
dti-1327	100	30	of	of	ADP
dti-1327	100	31	1	1	NUM
dti-1327	100	32	.	.	PUNCT
dti-1327	101	1	this	this	DET
dti-1327	101	2	mixture	mixture	NOUN
dti-1327	101	3	was	be	AUX
dti-1327	101	4	stirred	stir	VERB
dti-1327	101	5	for	for	ADP
dti-1327	101	6	30	30	NUM
dti-1327	101	7	minutes	minute	NOUN
dti-1327	101	8	.	.	PUNCT
dti-1327	102	1	γ-2	γ-2	PROPN
dti-1327	102	2	(	(	PUNCT
dti-1327	102	3	17.6	17.6	NUM
dti-1327	102	4	mg	mg	PROPN
dti-1327	102	5	,	,	PUNCT
dti-1327	102	6	0.00726	0.00726	NUM
dti-1327	102	7	mmol	mmol	NOUN
dti-1327	102	8	)	)	PUNCT
dti-1327	102	9	was	be	AUX
dti-1327	102	10	subsequently	subsequently	ADV
dti-1327	102	11	dissolved	dissolve	VERB
dti-1327	102	12	in	in	ADP
dti-1327	102	13	1	1	NUM
dti-1327	102	14	ml	ml	NOUN
dti-1327	102	15	of	of	ADP
dti-1327	102	16	dmso	dmso	NOUN
dti-1327	102	17	.	.	PUNCT
dti-1327	103	1	a	a	DET
dti-1327	103	2	volume	volume	NOUN
dti-1327	103	3	of	of	ADP
dti-1327	103	4	100	100	NUM
dti-1327	103	5	µl	µl	NOUN
dti-1327	103	6	of	of	ADP
dti-1327	103	7	triethylamine	triethylamine	NOUN
dti-1327	103	8	was	be	AUX
dti-1327	103	9	added	add	VERB
dti-1327	103	10	to	to	ADP
dti-1327	103	11	this	this	DET
dti-1327	103	12	solution	solution	NOUN
dti-1327	103	13	and	and	CCONJ
dti-1327	103	14	was	be	AUX
dti-1327	103	15	also	also	ADV
dti-1327	103	16	stirred	stir	VERB
dti-1327	103	17	for	for	ADP
dti-1327	103	18	30	30	NUM
dti-1327	103	19	minutes	minute	NOUN
dti-1327	103	20	.	.	PUNCT
dti-1327	104	1	the	the	DET
dti-1327	104	2	solution	solution	NOUN
dti-1327	104	3	of	of	ADP
dti-1327	104	4	γ-2	γ-2	PROPN
dti-1327	104	5	was	be	AUX
dti-1327	104	6	then	then	ADV
dti-1327	104	7	added	add	VERB
dti-1327	104	8	dropwise	dropwise	NOUN
dti-1327	104	9	to	to	ADP
dti-1327	104	10	the	the	DET
dti-1327	104	11	solution	solution	NOUN
dti-1327	104	12	of	of	ADP
dti-1327	104	13	1	1	NUM
dti-1327	104	14	.	.	PUNCT
dti-1327	105	1	the	the	DET
dti-1327	105	2	mixture	mixture	NOUN
dti-1327	105	3	was	be	AUX
dti-1327	105	4	left	leave	VERB
dti-1327	105	5	to	to	PART
dti-1327	105	6	react	react	VERB
dti-1327	105	7	overnight	overnight	ADV
dti-1327	105	8	.	.	PUNCT
dti-1327	106	1	the	the	DET
dti-1327	106	2	resulting	result	VERB
dti-1327	106	3	solution	solution	NOUN
dti-1327	106	4	was	be	AUX
dti-1327	106	5	filtered	filter	VERB
dti-1327	106	6	with	with	ADP
dti-1327	106	7	a	a	DET
dti-1327	106	8	0.45	0.45	NUM
dti-1327	106	9	µm	µm	ADP
dti-1327	106	10	filter	filter	NOUN
dti-1327	106	11	and	and	CCONJ
dti-1327	106	12	the	the	DET
dti-1327	106	13	crude	crude	ADJ
dti-1327	106	14	product	product	NOUN
dti-1327	106	15	precipitated	precipitate	VERB
dti-1327	106	16	with	with	ADP
dti-1327	106	17	25	25	NUM
dti-1327	106	18	ml	ml	NOUN
dti-1327	106	19	of	of	ADP
dti-1327	106	20	chilled	chilled	ADJ
dti-1327	106	21	isopropanol	isopropanol	NOUN
dti-1327	106	22	(	(	PUNCT
dti-1327	106	23	−78	−78	PROPN
dti-1327	106	24	°	°	NOUN
dti-1327	106	25	c	c	NOUN
dti-1327	106	26	)	)	PUNCT
dti-1327	106	27	.	.	PUNCT
dti-1327	107	1	a	a	DET
dti-1327	107	2	yellow	yellow	ADJ
dti-1327	107	3	solid	solid	NOUN
dti-1327	107	4	was	be	AUX
dti-1327	107	5	isolated	isolate	VERB
dti-1327	107	6	by	by	ADP
dti-1327	107	7	centrifugation	centrifugation	NOUN
dti-1327	107	8	and	and	CCONJ
dti-1327	107	9	redissolved	redissolve	VERB
dti-1327	107	10	with	with	ADP
dti-1327	107	11	1	1	NUM
dti-1327	107	12	ml	ml	NOUN
dti-1327	107	13	water	water	NOUN
dti-1327	107	14	and	and	CCONJ
dti-1327	107	15	purifi	purifi	PROPN
dti-1327	107	16	ed	ed	NOUN
dti-1327	107	17	by	by	ADP
dti-1327	107	18	hplc	hplc	PROPN
dti-1327	107	19	.	.	PUNCT
dti-1327	108	1	1h	1h	NUM
dti-1327	108	2	nmr	nmr	NOUN
dti-1327	108	3	(	(	PUNCT
dti-1327	108	4	d2o	d2o	PROPN
dti-1327	108	5	):	):	PUNCT
dti-1327	108	6	δ	δ	PROPN
dti-1327	108	7	8.64	8.64	NUM
dti-1327	108	8	(	(	PUNCT
dti-1327	108	9	s	s	PROPN
dti-1327	108	10	,	,	PUNCT
dti-1327	108	11	1h	1h	NUM
dti-1327	108	12	)	)	PUNCT
dti-1327	108	13	,	,	PUNCT
dti-1327	108	14	δ	δ	PROPN
dti-1327	108	15	7.68	7.68	NUM
dti-1327	108	16	(	(	PUNCT
dti-1327	108	17	d	d	PROPN
dti-1327	108	18	,	,	PUNCT
dti-1327	108	19	2h	2h	NUM
dti-1327	108	20	)	)	PUNCT
dti-1327	108	21	,	,	PUNCT
dti-1327	108	22	δ	δ	PROPN
dti-1327	108	23	6.85	6.85	NUM
dti-1327	108	24	(	(	PUNCT
dti-1327	108	25	d	d	NOUN
dti-1327	108	26	,	,	PUNCT
dti-1327	108	27	2h	2h	NUM
dti-1327	108	28	)	)	PUNCT
dti-1327	108	29	,	,	PUNCT
dti-1327	108	30	δ	δ	PROPN
dti-1327	108	31	4.61	4.61	NUM
dti-1327	108	32	(	(	PUNCT
dti-1327	108	33	s	s	PROPN
dti-1327	108	34	,	,	PUNCT
dti-1327	108	35	2h	2h	NUM
dti-1327	108	36	)	)	PUNCT
dti-1327	108	37	,	,	PUNCT
dti-1327	108	38	δ	δ	PROPN
dti-1327	108	39	3.83	3.83	NUM
dti-1327	108	40	–	–	PUNCT
dti-1327	108	41	3.20	3.20	NUM
dti-1327	108	42	(	(	PUNCT
dti-1327	108	43	m	m	NOUN
dti-1327	108	44	,	,	PUNCT
dti-1327	108	45	peg	peg	NOUN
dti-1327	108	46	)	)	PUNCT
dti-1327	108	47	,	,	PUNCT
dti-1327	108	48	δ	δ	PROPN
dti-1327	108	49	2.32	2.32	NUM
dti-1327	108	50	(	(	PUNCT
dti-1327	108	51	d	d	PROPN
dti-1327	108	52	,	,	PUNCT
dti-1327	108	53	12h	12h	NUM
dti-1327	108	54	)	)	PUNCT
dti-1327	108	55	,	,	PUNCT
dti-1327	108	56	δ	δ	PROPN
dti-1327	108	57	1.18	1.18	NUM
dti-1327	108	58	–	–	PUNCT
dti-1327	108	59	1.13	1.13	NUM
dti-1327	108	60	(	(	PUNCT
dti-1327	108	61	t	t	PROPN
dti-1327	108	62	,	,	PUNCT
dti-1327	108	63	11h	11h	NUM
dti-1327	108	64	)	)	PUNCT
dti-1327	108	65	.	.	PUNCT
dti-1327	109	1	maldi	maldi	NOUN
dti-1327	109	2	-	-	PUNCT
dti-1327	109	3	tof	tof	PROPN
dti-1327	109	4	:	:	PUNCT
dti-1327	109	5	2715.00	2715.00	NUM
dti-1327	109	6	m	m	PROPN
dti-1327	109	7	/	/	SYM
dti-1327	109	8	z	z	PROPN
dti-1327	109	9	(	(	PUNCT
dti-1327	109	10	m+h+	m+h+	NOUN
dti-1327	109	11	)	)	PUNCT
dti-1327	109	12	calculated	calculate	VERB
dti-1327	109	13	2876.25	2876.25	NUM
dti-1327	109	14	for	for	ADP
dti-1327	109	15	γ-4	γ-4	NOUN
dti-1327	109	16	.	.	PUNCT
dti-1327	110	1	yield	yield	NOUN
dti-1327	110	2	:	:	PUNCT
dti-1327	110	3	82.9	82.9	NUM
dti-1327	110	4	%	%	NOUN
dti-1327	110	5	based	base	VERB
dti-1327	110	6	on	on	ADP
dti-1327	110	7	γ-2	γ-2	PROPN
dti-1327	110	8	.	.	PUNCT
dti-1327	111	1	cell	cell	NOUN
dti-1327	111	2	lines	line	NOUN
dti-1327	111	3	and	and	CCONJ
dti-1327	111	4	culture	culture	NOUN
dti-1327	111	5	conditions	condition	NOUN
dti-1327	111	6	adriamycin	adriamycin	PRON
dti-1327	111	7	resistant	resistant	ADJ
dti-1327	111	8	ovarian	ovarian	ADJ
dti-1327	111	9	cancer	cancer	NOUN
dti-1327	111	10	cell	cell	NOUN
dti-1327	111	11	line	line	NOUN
dti-1327	111	12	(	(	PUNCT
dti-1327	111	13	a2780	a2780	NOUN
dti-1327	111	14	/	/	SYM
dti-1327	111	15	ad	ad	NOUN
dti-1327	111	16	)	)	PUNCT
dti-1327	111	17	and	and	CCONJ
dti-1327	111	18	chinese	chinese	ADJ
dti-1327	111	19	hamster	hamster	PROPN
dti-1327	111	20	ovary	ovary	NOUN
dti-1327	111	21	(	(	PUNCT
dti-1327	111	22	cho	cho	NOUN
dti-1327	111	23	)	)	PUNCT
dti-1327	111	24	cell	cell	NOUN
dti-1327	111	25	line	line	NOUN
dti-1327	111	26	were	be	AUX
dti-1327	111	27	cultured	cultured	ADJ
dti-1327	111	28	as	as	ADP
dti-1327	111	29	adherent	adherent	ADJ
dti-1327	111	30	monolayers	monolayer	NOUN
dti-1327	111	31	in	in	ADP
dti-1327	111	32	rpmi	rpmi	NOUN
dti-1327	111	33	1640	1640	NUM
dti-1327	111	34	(	(	PUNCT
dti-1327	111	35	invitrogen	invitrogen	PROPN
dti-1327	111	36	)	)	PUNCT
dti-1327	111	37	growth	growth	NOUN
dti-1327	111	38	media	medium	NOUN
dti-1327	111	39	containing	contain	VERB
dti-1327	111	40	l	l	NOUN
dti-1327	111	41	-	-	NOUN
dti-1327	111	42	glutamine	glutamine	NOUN
dti-1327	111	43	and	and	CCONJ
dti-1327	111	44	fa	fa	PROPN
dti-1327	111	45	supplemented	supplement	VERB
dti-1327	111	46	with	with	ADP
dti-1327	111	47	10,000	10,000	NUM
dti-1327	111	48	units	unit	NOUN
dti-1327	111	49	penicillin	penicillin	NOUN
dti-1327	111	50	and	and	CCONJ
dti-1327	111	51	10	10	NUM
dti-1327	111	52	mg	mg	NUM
dti-1327	111	53	/	/	SYM
dti-1327	111	54	ml	ml	NOUN
dti-1327	111	55	streptomycin	streptomycin	PROPN
dti-1327	111	56	(	(	PUNCT
dti-1327	111	57	sigma	sigma	PROPN
dti-1327	111	58	)	)	PUNCT
dti-1327	111	59	,	,	PUNCT
dti-1327	111	60	10	10	NUM
dti-1327	111	61	%	%	NOUN
dti-1327	111	62	(	(	PUNCT
dti-1327	111	63	v	v	NOUN
dti-1327	111	64	/	/	SYM
dti-1327	111	65	v	v	NOUN
dti-1327	111	66	)	)	PUNCT
dti-1327	111	67	fetal	fetal	ADJ
dti-1327	111	68	bovine	bovine	NOUN
dti-1327	111	69	serum	serum	NOUN
dti-1327	111	70	(	(	PUNCT
dti-1327	111	71	sigma	sigma	PROPN
dti-1327	111	72	)	)	PUNCT
dti-1327	111	73	.	.	PUNCT
dti-1327	112	1	cho	cho	PROPN
dti-1327	112	2	cells	cell	NOUN
dti-1327	112	3	were	be	AUX
dti-1327	112	4	obtained	obtain	VERB
dti-1327	112	5	from	from	ADP
dti-1327	112	6	the	the	DET
dti-1327	112	7	atcc	atcc	NOUN
dti-1327	112	8	.	.	PUNCT
dti-1327	113	1	the	the	DET
dti-1327	113	2	a2780	a2780	ADJ
dti-1327	113	3	/	/	SYM
dti-1327	113	4	ad	ad	NOUN
dti-1327	113	5	cell	cell	NOUN
dti-1327	113	6	line	line	NOUN
dti-1327	113	7	used	use	VERB
dti-1327	113	8	for	for	ADP
dti-1327	113	9	testing	testing	NOUN
dti-1327	113	10	was	be	AUX
dti-1327	113	11	provided	provide	VERB
dti-1327	113	12	by	by	ADP
dti-1327	113	13	the	the	DET
dti-1327	113	14	fox	fox	PROPN
dti-1327	113	15	chase	chase	NOUN
dti-1327	113	16	cancer	cancer	NOUN
dti-1327	113	17	centre	centre	NOUN
dti-1327	113	18	,	,	PUNCT
dti-1327	113	19	philadelphia	philadelphia	PROPN
dti-1327	113	20	.	.	PUNCT
dti-1327	114	1	cells	cell	NOUN
dti-1327	114	2	were	be	AUX
dti-1327	114	3	incubated	incubate	VERB
dti-1327	114	4	and	and	CCONJ
dti-1327	114	5	grown	grow	VERB
dti-1327	114	6	in	in	ADP
dti-1327	114	7	a	a	DET
dti-1327	114	8	vwr	vwr	PROPN
dti-1327	114	9	mammalian	mammalian	ADJ
dti-1327	114	10	incubator	incubator	NOUN
dti-1327	114	11	at	at	ADP
dti-1327	114	12	5	5	NUM
dti-1327	114	13	%	%	NOUN
dti-1327	114	14	co2	co2	NOUN
dti-1327	114	15	and	and	CCONJ
dti-1327	114	16	95	95	NUM
dti-1327	114	17	%	%	NOUN
dti-1327	114	18	humidity	humidity	NOUN
dti-1327	114	19	.	.	PUNCT
dti-1327	115	1	the	the	DET
dti-1327	115	2	presence	presence	NOUN
dti-1327	115	3	of	of	ADP
dti-1327	115	4	the	the	DET
dti-1327	115	5	fr	fr	NOUN
dti-1327	115	6	in	in	ADP
dti-1327	115	7	the	the	DET
dti-1327	115	8	a2780	a2780	NOUN
dti-1327	115	9	/	/	SYM
dti-1327	115	10	ad	ad	NOUN
dti-1327	115	11	line	line	NOUN
dti-1327	115	12	(	(	PUNCT
dti-1327	115	13	and	and	CCONJ
dti-1327	115	14	indeed	indeed	ADV
dti-1327	115	15	absence	absence	NOUN
dti-1327	115	16	in	in	ADP
dti-1327	115	17	cho	cho	NOUN
dti-1327	115	18	cells	cell	NOUN
dti-1327	115	19	)	)	PUNCT
dti-1327	115	20	was	be	AUX
dti-1327	115	21	followed	follow	VERB
dti-1327	115	22	by	by	ADP
dti-1327	115	23	rt	rt	PROPN
dti-1327	115	24	-	-	PUNCT
dti-1327	115	25	pcr	pcr	ADJ
dti-1327	115	26	and	and	CCONJ
dti-1327	115	27	confocal	confocal	ADJ
dti-1327	115	28	microscopy	microscopy	NOUN
dti-1327	115	29	(	(	PUNCT
dti-1327	115	30	doyle	doyle	PROPN
dti-1327	115	31	et	et	PROPN
dti-1327	115	32	al	al	PROPN
dti-1327	115	33	,	,	PUNCT
dti-1327	115	34	unpublished	unpublished	ADJ
dti-1327	115	35	results	result	NOUN
dti-1327	115	36	)	)	PUNCT
dti-1327	115	37	.	.	PUNCT
dti-1327	116	1	all	all	DET
dti-1327	116	2	preparations	preparation	NOUN
dti-1327	116	3	for	for	ADP
dti-1327	116	4	cell	cell	NOUN
dti-1327	116	5	culture	culture	NOUN
dti-1327	116	6	and	and	CCONJ
dti-1327	116	7	assays	assay	NOUN
dti-1327	116	8	were	be	AUX
dti-1327	116	9	conducted	conduct	VERB
dti-1327	116	10	in	in	ADP
dti-1327	116	11	a	a	DET
dti-1327	116	12	sterile	sterile	ADJ
dti-1327	116	13	environment	environment	NOUN
dti-1327	116	14	under	under	ADP
dti-1327	116	15	a	a	DET
dti-1327	116	16	labconco	labconco	NOUN
dti-1327	116	17	purifi	purifi	NOUN
dti-1327	117	1	er	er	INTJ
dti-1327	117	2	i	i	PRON
dti-1327	117	3	laminar	laminar	ADJ
dti-1327	117	4	fl	fl	INTJ
dti-1327	117	5	ow	ow	INTJ
dti-1327	117	6	hood	hood	NOUN
dti-1327	117	7	.	.	PUNCT
dti-1327	118	1	cells	cell	NOUN
dti-1327	118	2	were	be	AUX
dti-1327	118	3	cultured	cultured	ADJ
dti-1327	118	4	in	in	ADP
dti-1327	118	5	millipore	millipore	PROPN
dti-1327	118	6	250	250	NUM
dti-1327	118	7	ml	ml	ADP
dti-1327	118	8	culture	culture	NOUN
dti-1327	118	9	bottles	bottle	NOUN
dti-1327	118	10	with	with	ADP
dti-1327	118	11	vented	vent	VERB
dti-1327	118	12	lids	lid	NOUN
dti-1327	118	13	.	.	PUNCT
dti-1327	119	1	drug	drug	NOUN
dti-1327	119	2	cytotoxicity	cytotoxicity	NOUN
dti-1327	119	3	the	the	DET
dti-1327	119	4	proliferation	proliferation	NOUN
dti-1327	119	5	of	of	ADP
dti-1327	119	6	the	the	DET
dti-1327	119	7	exponential	exponential	ADJ
dti-1327	119	8	phase	phase	NOUN
dti-1327	119	9	cultures	culture	NOUN
dti-1327	119	10	of	of	ADP
dti-1327	119	11	a2780	a2780	NOUN
dti-1327	119	12	/	/	SYM
dti-1327	119	13	ad	ad	NOUN
dti-1327	119	14	and	and	CCONJ
dti-1327	119	15	cho	cho	NOUN
dti-1327	119	16	cells	cell	NOUN
dti-1327	119	17	was	be	AUX
dti-1327	119	18	assessed	assess	VERB
dti-1327	119	19	by	by	ADP
dti-1327	119	20	colorimetric	colorimetric	ADJ
dti-1327	119	21	assay	assay	NOUN
dti-1327	119	22	.	.	PUNCT
dti-1327	120	1	wsk-8	wsk-8	NUM
dti-1327	120	2	(	(	PUNCT
dti-1327	120	3	dojindo	dojindo	NOUN
dti-1327	120	4	)	)	PUNCT
dti-1327	120	5	was	be	AUX
dti-1327	120	6	performed	perform	VERB
dti-1327	120	7	according	accord	VERB
dti-1327	120	8	to	to	ADP
dti-1327	120	9	manufacturer	manufacturer	NOUN
dti-1327	120	10	’s	’s	PART
dti-1327	120	11	instructions	instruction	NOUN
dti-1327	120	12	.	.	PUNCT
dti-1327	121	1	adherent	adherent	ADJ
dti-1327	121	2	cell	cell	NOUN
dti-1327	121	3	cultures	culture	NOUN
dti-1327	121	4	were	be	AUX
dti-1327	121	5	harvested	harvest	VERB
dti-1327	121	6	by	by	ADP
dti-1327	121	7	stripping	strip	VERB
dti-1327	121	8	of	of	ADP
dti-1327	121	9	culture	culture	NOUN
dti-1327	121	10	fl	fl	PROPN
dti-1327	121	11	asks	ask	VERB
dti-1327	121	12	by	by	ADP
dti-1327	121	13	a	a	DET
dti-1327	121	14	non	non	ADJ
dti-1327	121	15	-	-	ADJ
dti-1327	121	16	enzymatic	enzymatic	ADJ
dti-1327	121	17	cell	cell	NOUN
dti-1327	121	18	stripper	stripper	NOUN
dti-1327	121	19	(	(	PUNCT
dti-1327	121	20	mediatech	mediatech	NOUN
dti-1327	121	21	)	)	PUNCT
dti-1327	121	22	after	after	ADP
dti-1327	121	23	a	a	DET
dti-1327	121	24	30	30	NUM
dti-1327	121	25	minute	minute	NOUN
dti-1327	121	26	incubation	incubation	NOUN
dti-1327	121	27	period	period	NOUN
dti-1327	121	28	.	.	PUNCT
dti-1327	122	1	the	the	DET
dti-1327	122	2	cells	cell	NOUN
dti-1327	122	3	were	be	AUX
dti-1327	122	4	then	then	ADV
dti-1327	122	5	collected	collect	VERB
dti-1327	122	6	.	.	PUNCT
dti-1327	123	1	the	the	DET
dti-1327	123	2	cell	cell	NOUN
dti-1327	123	3	densities	density	NOUN
dti-1327	123	4	were	be	AUX
dti-1327	123	5	adjusted	adjust	VERB
dti-1327	123	6	using	use	VERB
dti-1327	123	7	fa	fa	NOUN
dti-1327	123	8	-	-	PUNCT
dti-1327	123	9	free	free	ADJ
dti-1327	123	10	rpmi	rpmi	NOUN
dti-1327	123	11	1640	1640	NUM
dti-1327	123	12	media	medium	NOUN
dti-1327	123	13	to	to	ADP
dti-1327	123	14	3.0	3.0	NUM
dti-1327	123	15	×	×	NOUN
dti-1327	123	16	104	104	NUM
dti-1327	123	17	cells	cell	NOUN
dti-1327	123	18	/	/	SYM
dti-1327	123	19	ml	ml	NOUN
dti-1327	123	20	to	to	PART
dti-1327	123	21	guarantee	guarantee	VERB
dti-1327	123	22	exponential	exponential	ADJ
dti-1327	123	23	growth	growth	NOUN
dti-1327	123	24	for	for	ADP
dti-1327	123	25	the	the	DET
dti-1327	123	26	period	period	NOUN
dti-1327	123	27	of	of	ADP
dti-1327	123	28	drug	drug	NOUN
dti-1327	123	29	exposure	exposure	NOUN
dti-1327	123	30	.	.	PUNCT
dti-1327	124	1	to	to	ADP
dti-1327	124	2	each	each	PRON
dti-1327	124	3	well	well	ADV
dti-1327	124	4	,	,	PUNCT
dti-1327	124	5	aliquots	aliquot	NOUN
dti-1327	124	6	of	of	ADP
dti-1327	124	7	100	100	NUM
dti-1327	124	8	µl	µl	NOUN
dti-1327	124	9	were	be	AUX
dti-1327	124	10	inoculated	inoculate	VERB
dti-1327	124	11	.	.	PUNCT
dti-1327	125	1	after	after	ADP
dti-1327	125	2	a	a	DET
dti-1327	125	3	24	24	NUM
dti-1327	125	4	hour	hour	NOUN
dti-1327	125	5	incubation	incubation	NOUN
dti-1327	125	6	time	time	NOUN
dti-1327	125	7	to	to	PART
dti-1327	125	8	facilitate	facilitate	VERB
dti-1327	125	9	adherence	adherence	NOUN
dti-1327	125	10	,	,	PUNCT
dti-1327	125	11	the	the	DET
dti-1327	125	12	fa	fa	PROPN
dti-1327	125	13	free	free	ADJ
dti-1327	125	14	rpmi	rpmi	NOUN
dti-1327	125	15	media	medium	NOUN
dti-1327	125	16	was	be	AUX
dti-1327	125	17	removed	remove	VERB
dti-1327	125	18	and	and	CCONJ
dti-1327	125	19	replaced	replace	VERB
dti-1327	125	20	with	with	ADP
dti-1327	125	21	200	200	NUM
dti-1327	125	22	µl	µl	NOUN
dti-1327	125	23	of	of	ADP
dti-1327	125	24	fresh	fresh	ADJ
dti-1327	125	25	media	medium	NOUN
dti-1327	125	26	containing	contain	VERB
dti-1327	125	27	different	different	ADJ
dti-1327	125	28	concentrations	concentration	NOUN
dti-1327	125	29	of	of	ADP
dti-1327	125	30	1	1	NUM
dti-1327	125	31	,	,	PUNCT
dti-1327	125	32	γ-2	γ-2	PROPN
dti-1327	125	33	,	,	PUNCT
dti-1327	125	34	γ-3	γ-3	PROPN
dti-1327	125	35	,	,	PUNCT
dti-1327	125	36	γ-4	γ-4	PROPN
dti-1327	125	37	,	,	PUNCT
dti-1327	125	38	dota	dota	PROPN
dti-1327	125	39	and	and	CCONJ
dti-1327	125	40	a	a	DET
dti-1327	125	41	control	control	NOUN
dti-1327	125	42	of	of	ADP
dti-1327	125	43	azt	azt	PROPN
dti-1327	125	44	.	.	PUNCT
dti-1327	126	1	the	the	DET
dti-1327	126	2	cells	cell	NOUN
dti-1327	126	3	were	be	AUX
dti-1327	126	4	then	then	ADV
dti-1327	126	5	incubated	incubate	VERB
dti-1327	126	6	for	for	ADP
dti-1327	126	7	72	72	NUM
dti-1327	126	8	hours	hour	NOUN
dti-1327	126	9	.	.	PUNCT
dti-1327	127	1	optical	optical	ADJ
dti-1327	127	2	densities	density	NOUN
dti-1327	127	3	were	be	AUX
dti-1327	127	4	measured	measure	VERB
dti-1327	127	5	at	at	ADP
dti-1327	127	6	450	450	NUM
dti-1327	127	7	nm	nm	NOUN
dti-1327	127	8	using	use	VERB
dti-1327	127	9	a	a	DET
dti-1327	127	10	plate	plate	NOUN
dti-1327	127	11	reader	reader	NOUN
dti-1327	127	12	.	.	PUNCT
dti-1327	128	1	the	the	DET
dti-1327	128	2	percentage	percentage	NOUN
dti-1327	128	3	of	of	ADP
dti-1327	128	4	cell	cell	NOUN
dti-1327	128	5	viability	viability	NOUN
dti-1327	128	6	was	be	AUX
dti-1327	128	7	determined	determine	VERB
dti-1327	128	8	relative	relative	ADJ
dti-1327	128	9	to	to	ADP
dti-1327	128	10	untreated	untreated	ADJ
dti-1327	128	11	control	control	NOUN
dti-1327	128	12	microcultures	microculture	NOUN
dti-1327	128	13	.	.	PUNCT
dti-1327	129	1	stability	stability	NOUN
dti-1327	129	2	studies	study	VERB
dti-1327	129	3	2	2	NUM
dti-1327	129	4	mm	mm	NOUN
dti-1327	129	5	solutions	solution	NOUN
dti-1327	129	6	of	of	ADP
dti-1327	129	7	γ-4	γ-4	NOUN
dti-1327	129	8	were	be	AUX
dti-1327	129	9	prepared	prepare	VERB
dti-1327	129	10	from	from	ADP
dti-1327	129	11	25	25	NUM
dti-1327	129	12	mm	mm	NOUN
dti-1327	129	13	hepes	hepe	NOUN
dti-1327	129	14	(	(	PUNCT
dti-1327	129	15	ph	ph	NOUN
dti-1327	129	16	7.4	7.4	NUM
dti-1327	129	17	)	)	PUNCT
dti-1327	129	18	and	and	CCONJ
dti-1327	129	19	rpmi	rpmi	VERB
dti-1327	129	20	1640	1640	NUM
dti-1327	129	21	fa	fa	NOUN
dti-1327	129	22	-	-	PUNCT
dti-1327	129	23	free	free	ADJ
dti-1327	129	24	media	medium	NOUN
dti-1327	129	25	.	.	PUNCT
dti-1327	130	1	these	these	DET
dti-1327	130	2	solutions	solution	NOUN
dti-1327	130	3	were	be	AUX
dti-1327	130	4	incubated	incubate	VERB
dti-1327	130	5	over	over	ADP
dti-1327	130	6	72	72	NUM
dti-1327	130	7	hours	hour	NOUN
dti-1327	130	8	at	at	ADP
dti-1327	130	9	37	37	NUM
dti-1327	130	10	°	°	NOUN
dti-1327	130	11	c	c	NOUN
dti-1327	130	12	.	.	PUNCT
dti-1327	131	1	solutions	solution	NOUN
dti-1327	131	2	made	make	VERB
dti-1327	131	3	from	from	ADP
dti-1327	131	4	the	the	DET
dti-1327	131	5	media	medium	NOUN
dti-1327	131	6	were	be	AUX
dti-1327	131	7	fi	fi	NOUN
dti-1327	131	8	ltered	ltere	VERB
dti-1327	131	9	by	by	ADP
dti-1327	131	10	centrifugation	centrifugation	NOUN
dti-1327	131	11	using	use	VERB
dti-1327	131	12	a	a	DET
dti-1327	131	13	centrifugal	centrifugal	ADJ
dti-1327	131	14	fi	fi	NOUN
dti-1327	131	15	lter	lter	NOUN
dti-1327	131	16	(	(	PUNCT
dti-1327	131	17	pall	pall	NOUN
dti-1327	131	18	life	life	NOUN
dti-1327	131	19	sciences	sciences	PROPN
dti-1327	131	20	,	,	PUNCT
dti-1327	131	21	mw	mw	PROPN
dti-1327	131	22	:	:	PUNCT
dti-1327	131	23	1000	1000	NUM
dti-1327	131	24	g	g	NOUN
dti-1327	131	25	/	/	SYM
dti-1327	131	26	mol	mol	NOUN
dti-1327	131	27	)	)	PUNCT
dti-1327	131	28	at	at	ADP
dti-1327	131	29	4,000	4,000	NUM
dti-1327	131	30	rpm	rpm	NOUN
dti-1327	131	31	over	over	ADP
dti-1327	131	32	17	17	NUM
dti-1327	131	33	targeting	target	VERB
dti-1327	131	34	gallium	gallium	NOUN
dti-1327	131	35	to	to	ADP
dti-1327	131	36	cancer	cancer	NOUN
dti-1327	131	37	cells	cell	NOUN
dti-1327	131	38	through	through	ADP
dti-1327	131	39	the	the	DET
dti-1327	131	40	folate	folate	NOUN
dti-1327	131	41	receptor	receptor	NOUN
dti-1327	131	42	drug	drug	NOUN
dti-1327	131	43	target	target	NOUN
dti-1327	131	44	insights	insight	NOUN
dti-1327	131	45	2008:3	2008:3	NUM
dti-1327	131	46	15	15	NUM
dti-1327	131	47	minutes	minute	NOUN
dti-1327	131	48	.	.	PUNCT
dti-1327	132	1	analytical	analytical	ADJ
dti-1327	132	2	c18	c18	NOUN
dti-1327	132	3	reverse	reverse	VERB
dti-1327	132	4	phase	phase	NOUN
dti-1327	132	5	hplc	hplc	NOUN
dti-1327	132	6	analysis	analysis	NOUN
dti-1327	132	7	was	be	AUX
dti-1327	132	8	conducted	conduct	VERB
dti-1327	132	9	at	at	ADP
dti-1327	132	10	0	0	NUM
dti-1327	132	11	,	,	PUNCT
dti-1327	132	12	1	1	NUM
dti-1327	132	13	,	,	PUNCT
dti-1327	132	14	24	24	NUM
dti-1327	132	15	,	,	PUNCT
dti-1327	132	16	48	48	NUM
dti-1327	132	17	and	and	CCONJ
dti-1327	132	18	72	72	NUM
dti-1327	132	19	hours	hour	NOUN
dti-1327	132	20	.	.	PUNCT
dti-1327	133	1	at	at	ADP
dti-1327	133	2	72	72	NUM
dti-1327	133	3	hours	hour	NOUN
dti-1327	133	4	,	,	PUNCT
dti-1327	133	5	fractions	fraction	NOUN
dti-1327	133	6	were	be	AUX
dti-1327	133	7	analyzed	analyze	VERB
dti-1327	133	8	for	for	ADP
dti-1327	133	9	the	the	DET
dti-1327	133	10	presence	presence	NOUN
dti-1327	133	11	of	of	ADP
dti-1327	133	12	gallium	gallium	NOUN
dti-1327	133	13	via	via	ADP
dti-1327	133	14	inductively	inductively	ADV
dti-1327	133	15	coupled	couple	VERB
dti-1327	133	16	plasma	plasma	NOUN
dti-1327	133	17	(	(	PUNCT
dti-1327	133	18	icp	icp	PROPN
dti-1327	133	19	)	)	PUNCT
dti-1327	133	20	.	.	PUNCT
dti-1327	134	1	results	result	NOUN
dti-1327	134	2	and	and	CCONJ
dti-1327	134	3	discussion	discussion	NOUN
dti-1327	134	4	chemical	chemical	NOUN
dti-1327	134	5	synthesis	synthesis	NOUN
dti-1327	134	6	the	the	DET
dti-1327	134	7	synthesis	synthesis	NOUN
dti-1327	134	8	of	of	ADP
dti-1327	134	9	1	1	NUM
dti-1327	134	10	(	(	PUNCT
dti-1327	134	11	scheme	scheme	NOUN
dti-1327	134	12	1	1	NUM
dti-1327	134	13	)	)	PUNCT
dti-1327	134	14	was	be	AUX
dti-1327	134	15	prepared	prepare	VERB
dti-1327	134	16	by	by	ADP
dti-1327	134	17	direct	direct	ADJ
dti-1327	134	18	addition	addition	NOUN
dti-1327	134	19	of	of	ADP
dti-1327	134	20	stoichiometric	stoichiometric	ADJ
dti-1327	134	21	equivalents	equivalent	NOUN
dti-1327	134	22	of	of	ADP
dti-1327	134	23	gallium	gallium	NOUN
dti-1327	134	24	to	to	ADP
dti-1327	134	25	dota	dota	PROPN
dti-1327	134	26	under	under	ADP
dti-1327	134	27	acidic	acidic	ADJ
dti-1327	134	28	(	(	PUNCT
dti-1327	134	29	ph	ph	ADJ
dti-1327	134	30	4.8	4.8	NUM
dti-1327	134	31	)	)	PUNCT
dti-1327	134	32	conditions	condition	NOUN
dti-1327	134	33	.	.	PUNCT
dti-1327	135	1	crystals	crystal	NOUN
dti-1327	135	2	were	be	AUX
dti-1327	135	3	grown	grow	VERB
dti-1327	135	4	after	after	ADP
dti-1327	135	5	concentrating	concentrate	VERB
dti-1327	135	6	the	the	DET
dti-1327	135	7	solution	solution	NOUN
dti-1327	135	8	to	to	ADP
dti-1327	135	9	its	its	PRON
dti-1327	135	10	saturation	saturation	NOUN
dti-1327	135	11	point	point	NOUN
dti-1327	135	12	.	.	PUNCT
dti-1327	136	1	five	five	NUM
dti-1327	136	2	volume	volume	NOUN
dti-1327	136	3	equivalents	equivalent	NOUN
dti-1327	136	4	of	of	ADP
dti-1327	136	5	acetone	acetone	NOUN
dti-1327	136	6	was	be	AUX
dti-1327	136	7	then	then	ADV
dti-1327	136	8	added	add	VERB
dti-1327	136	9	and	and	CCONJ
dti-1327	136	10	the	the	DET
dti-1327	136	11	suspension	suspension	NOUN
dti-1327	136	12	fi	fi	NOUN
dti-1327	136	13	ltered	ltere	VERB
dti-1327	136	14	.	.	PUNCT
dti-1327	137	1	the	the	DET
dti-1327	137	2	clear	clear	ADJ
dti-1327	137	3	,	,	PUNCT
dti-1327	137	4	colorless	colorless	ADJ
dti-1327	137	5	solution	solution	NOUN
dti-1327	137	6	was	be	AUX
dti-1327	137	7	then	then	ADV
dti-1327	137	8	placed	place	VERB
dti-1327	137	9	at	at	ADP
dti-1327	137	10	4	4	NUM
dti-1327	137	11	°	°	NOUN
dti-1327	137	12	c	c	NOUN
dti-1327	137	13	.	.	PUNCT
dti-1327	138	1	colorless	colorless	ADJ
dti-1327	138	2	needle	needle	NOUN
dti-1327	138	3	-	-	PUNCT
dti-1327	138	4	shaped	shape	VERB
dti-1327	138	5	crystals	crystal	NOUN
dti-1327	138	6	formed	form	VERB
dti-1327	138	7	after	after	ADP
dti-1327	138	8	24	24	NUM
dti-1327	138	9	hours	hour	NOUN
dti-1327	138	10	.	.	PUNCT
dti-1327	139	1	fa	fa	PROPN
dti-1327	139	2	was	be	AUX
dti-1327	139	3	activated	activate	VERB
dti-1327	139	4	by	by	ADP
dti-1327	139	5	a	a	DET
dti-1327	139	6	reaction	reaction	NOUN
dti-1327	139	7	with	with	ADP
dti-1327	139	8	dcc	dcc	PROPN
dti-1327	139	9	/	/	SYM
dti-1327	139	10	nhs	nhs	PROPN
dti-1327	139	11	to	to	PART
dti-1327	139	12	couple	couple	VERB
dti-1327	139	13	it	it	PRON
dti-1327	139	14	to	to	ADP
dti-1327	139	15	peg	peg	VERB
dti-1327	139	16	.	.	PUNCT
dti-1327	140	1	α	α	X
dti-1327	140	2	/	/	SYM
dti-1327	140	3	γ-2	γ-2	NOUN
dti-1327	140	4	was	be	AUX
dti-1327	140	5	subsequently	subsequently	ADV
dti-1327	140	6	separated	separate	VERB
dti-1327	140	7	via	via	ADP
dti-1327	140	8	iec	iec	NOUN
dti-1327	140	9	using	use	VERB
dti-1327	140	10	a	a	DET
dti-1327	140	11	weak	weak	ADJ
dti-1327	140	12	anion	anion	NOUN
dti-1327	140	13	exchange	exchange	NOUN
dti-1327	140	14	column	column	NOUN
dti-1327	140	15	as	as	SCONJ
dti-1327	140	16	shown	show	VERB
dti-1327	140	17	in	in	ADP
dti-1327	140	18	scheme	scheme	NOUN
dti-1327	140	19	2	2	NUM
dti-1327	140	20	.	.	PUNCT
dti-1327	141	1	the	the	DET
dti-1327	141	2	fi	fi	NOUN
dti-1327	141	3	rst	rst	ADJ
dti-1327	141	4	and	and	CCONJ
dti-1327	141	5	second	second	ADJ
dti-1327	141	6	peak	peak	NOUN
dti-1327	141	7	eluted	elute	VERB
dti-1327	141	8	both	both	DET
dti-1327	141	9	isomers	isomer	NOUN
dti-1327	141	10	.	.	PUNCT
dti-1327	142	1	upon	upon	SCONJ
dti-1327	142	2	increasing	increase	VERB
dti-1327	142	3	the	the	DET
dti-1327	142	4	conductivity	conductivity	NOUN
dti-1327	142	5	to	to	ADP
dti-1327	142	6	3	3	NUM
dti-1327	142	7	ms	ms	PROPN
dti-1327	142	8	/	/	SYM
dti-1327	142	9	cm	cm	PROPN
dti-1327	142	10	,	,	PUNCT
dti-1327	142	11	a	a	DET
dti-1327	142	12	third	third	ADJ
dti-1327	142	13	peak	peak	NOUN
dti-1327	142	14	eluted	elute	VERB
dti-1327	142	15	to	to	PART
dti-1327	142	16	give	give	VERB
dti-1327	142	17	γ-2	γ-2	NOUN
dti-1327	142	18	.	.	PUNCT
dti-1327	143	1	analytical	analytical	ADJ
dti-1327	143	2	hplc	hplc	NOUN
dti-1327	143	3	runs	run	NOUN
dti-1327	143	4	of	of	ADP
dti-1327	143	5	fractions	fraction	NOUN
dti-1327	143	6	collected	collect	VERB
dti-1327	143	7	from	from	ADP
dti-1327	143	8	iec	iec	PROPN
dti-1327	143	9	confi	confi	PROPN
dti-1327	143	10	rmed	rme	VERB
dti-1327	143	11	the	the	DET
dti-1327	143	12	identity	identity	NOUN
dti-1327	143	13	of	of	ADP
dti-1327	143	14	the	the	DET
dti-1327	143	15	isomers	isomer	NOUN
dti-1327	143	16	.	.	PUNCT
dti-1327	144	1	previous	previous	ADJ
dti-1327	144	2	work	work	NOUN
dti-1327	144	3	separating	separate	VERB
dti-1327	144	4	both	both	DET
dti-1327	144	5	isomers	isomer	NOUN
dti-1327	144	6	established	establish	VERB
dti-1327	144	7	the	the	DET
dti-1327	144	8	α-2	α-2	NOUN
dti-1327	144	9	eluting	elute	VERB
dti-1327	144	10	at	at	ADP
dti-1327	144	11	a	a	DET
dti-1327	144	12	later	later	ADJ
dti-1327	144	13	time	time	NOUN
dti-1327	144	14	than	than	ADP
dti-1327	144	15	the	the	DET
dti-1327	144	16	γ	γ	NOUN
dti-1327	144	17	-	-	PUNCT
dti-1327	144	18	isomer	isomer	ADJ
dti-1327	144	19	with	with	ADP
dti-1327	144	20	reverse	reverse	ADJ
dti-1327	144	21	phase	phase	NOUN
dti-1327	144	22	hplc	hplc	NOUN
dti-1327	144	23	(	(	PUNCT
dti-1327	144	24	doyle	doyle	PROPN
dti-1327	144	25	et	et	PROPN
dti-1327	144	26	al	al	PROPN
dti-1327	144	27	.	.	PROPN
dti-1327	144	28	2008	2008	NUM
dti-1327	144	29	)	)	PUNCT
dti-1327	144	30	.	.	PUNCT
dti-1327	145	1	the	the	DET
dti-1327	145	2	identities	identity	NOUN
dti-1327	145	3	of	of	ADP
dti-1327	145	4	the	the	DET
dti-1327	145	5	peaks	peak	NOUN
dti-1327	145	6	from	from	ADP
dti-1327	145	7	fractions	fraction	NOUN
dti-1327	145	8	collected	collect	VERB
dti-1327	145	9	from	from	ADP
dti-1327	145	10	the	the	DET
dti-1327	145	11	iec	iec	NOUN
dti-1327	145	12	were	be	AUX
dti-1327	145	13	confi	confi	VERB
dti-1327	145	14	rmed	rme	VERB
dti-1327	145	15	with	with	ADP
dti-1327	145	16	γ-2	γ-2	NOUN
dti-1327	145	17	eluting	elute	VERB
dti-1327	145	18	at	at	ADP
dti-1327	145	19	tr	tr	NOUN
dti-1327	145	20	=	=	SYM
dti-1327	145	21	23.64	23.64	NUM
dti-1327	145	22	minutes	minute	NOUN
dti-1327	145	23	and	and	CCONJ
dti-1327	145	24	α-2	α-2	NOUN
dti-1327	145	25	subsequently	subsequently	ADV
dti-1327	145	26	eluting	elute	VERB
dti-1327	145	27	at	at	ADP
dti-1327	145	28	tr	tr	NOUN
dti-1327	145	29	=	=	NOUN
dti-1327	145	30	26.34	26.34	NUM
dti-1327	145	31	minutes	minute	NOUN
dti-1327	145	32	.	.	PUNCT
dti-1327	146	1	γ-3	γ-3	PROPN
dti-1327	146	2	was	be	AUX
dti-1327	146	3	made	make	VERB
dti-1327	146	4	with	with	ADP
dti-1327	146	5	sulfo	sulfo	NOUN
dti-1327	146	6	-	-	PUNCT
dti-1327	146	7	nhs	nhs	PROPN
dti-1327	146	8	/	/	SYM
dti-1327	146	9	edc	edc	PROPN
dti-1327	146	10	water	water	PROPN
dti-1327	146	11	soluble	soluble	PROPN
dti-1327	146	12	cross	cross	NOUN
dti-1327	146	13	linkers	linker	NOUN
dti-1327	146	14	to	to	PART
dti-1327	146	15	give	give	VERB
dti-1327	146	16	the	the	DET
dti-1327	146	17	metal	metal	NOUN
dti-1327	146	18	-	-	PUNCT
dti-1327	146	19	free	free	ADJ
dti-1327	146	20	compound	compound	NOUN
dti-1327	146	21	.	.	PUNCT
dti-1327	147	1	edc	edc	PROPN
dti-1327	147	2	formed	form	VERB
dti-1327	147	3	an	an	DET
dti-1327	147	4	o	o	NOUN
dti-1327	147	5	-	-	NOUN
dti-1327	147	6	acylisourea	acylisourea	NOUN
dti-1327	147	7	intermediate	intermediate	ADJ
dti-1327	147	8	with	with	ADP
dti-1327	147	9	dota	dota	PROPN
dti-1327	147	10	.	.	PUNCT
dti-1327	148	1	this	this	DET
dti-1327	148	2	converts	convert	NOUN
dti-1327	148	3	to	to	ADP
dti-1327	148	4	the	the	DET
dti-1327	148	5	sulfo	sulfo	NOUN
dti-1327	148	6	-	-	PUNCT
dti-1327	148	7	hydroxysuccinimide	hydroxysuccinimide	NOUN
dti-1327	148	8	dota	dota	PROPN
dti-1327	148	9	ester	ester	NOUN
dti-1327	148	10	in	in	ADP
dti-1327	148	11	the	the	DET
dti-1327	148	12	presence	presence	NOUN
dti-1327	148	13	of	of	ADP
dti-1327	148	14	the	the	DET
dti-1327	148	15	amine	amine	ADJ
dti-1327	148	16	reactive	reactive	ADJ
dti-1327	148	17	sulfo	sulfo	NOUN
dti-1327	148	18	-	-	PUNCT
dti-1327	148	19	nhs	nhs	PROPN
dti-1327	148	20	.	.	PUNCT
dti-1327	149	1	amidation	amidation	PROPN
dti-1327	149	2	proceeds	proceed	VERB
dti-1327	149	3	upon	upon	SCONJ
dti-1327	149	4	addition	addition	NOUN
dti-1327	149	5	of	of	ADP
dti-1327	149	6	the	the	DET
dti-1327	149	7	amine	amine	ADJ
dti-1327	149	8	group	group	NOUN
dti-1327	149	9	of	of	ADP
dti-1327	149	10	γ-2	γ-2	PROPN
dti-1327	149	11	(	(	PUNCT
dti-1327	149	12	see	see	VERB
dti-1327	149	13	scheme	scheme	NOUN
dti-1327	149	14	3	3	NUM
dti-1327	149	15	)	)	PUNCT
dti-1327	149	16	.	.	PUNCT
dti-1327	150	1	coupling	coupling	NOUN
dti-1327	150	2	of	of	ADP
dti-1327	150	3	γ-2	γ-2	NOUN
dti-1327	150	4	and	and	CCONJ
dti-1327	150	5	1	1	NUM
dti-1327	150	6	proceeded	proceed	VERB
dti-1327	150	7	using	use	VERB
dti-1327	150	8	dcc/	dcc/	NUM
dti-1327	150	9	nhs	nhs	PROPN
dti-1327	150	10	coupling	coupling	NOUN
dti-1327	150	11	agents	agent	NOUN
dti-1327	150	12	(	(	PUNCT
dti-1327	150	13	see	see	VERB
dti-1327	150	14	scheme	scheme	NOUN
dti-1327	150	15	4	4	NUM
dti-1327	150	16	)	)	PUNCT
dti-1327	150	17	.	.	PUNCT
dti-1327	151	1	tea	tea	NOUN
dti-1327	151	2	was	be	AUX
dti-1327	151	3	added	add	VERB
dti-1327	151	4	to	to	ADP
dti-1327	151	5	γ-2	γ-2	NOUN
dti-1327	151	6	improving	improve	VERB
dti-1327	151	7	the	the	DET
dti-1327	151	8	nucleophilicity	nucleophilicity	NOUN
dti-1327	151	9	of	of	ADP
dti-1327	151	10	the	the	DET
dti-1327	151	11	amine	amine	ADJ
dti-1327	151	12	end	end	NOUN
dti-1327	151	13	of	of	ADP
dti-1327	151	14	the	the	DET
dti-1327	151	15	conjugate	conjugate	NOUN
dti-1327	151	16	.	.	PUNCT
dti-1327	152	1	since	since	SCONJ
dti-1327	152	2	1	1	NUM
dti-1327	152	3	is	be	AUX
dti-1327	152	4	only	only	ADV
dti-1327	152	5	soluble	soluble	ADJ
dti-1327	152	6	in	in	ADP
dti-1327	152	7	water	water	NOUN
dti-1327	152	8	,	,	PUNCT
dti-1327	152	9	it	it	PRON
dti-1327	152	10	was	be	AUX
dti-1327	152	11	dissolved	dissolve	VERB
dti-1327	152	12	in	in	ADP
dti-1327	152	13	a	a	DET
dti-1327	152	14	minimal	minimal	ADJ
dti-1327	152	15	amount	amount	NOUN
dti-1327	152	16	of	of	ADP
dti-1327	152	17	water	water	NOUN
dti-1327	152	18	followed	follow	VERB
dti-1327	152	19	by	by	ADP
dti-1327	152	20	addition	addition	NOUN
dti-1327	152	21	of	of	ADP
dti-1327	152	22	dmso	dmso	NOUN
dti-1327	152	23	.	.	PUNCT
dti-1327	153	1	the	the	DET
dti-1327	153	2	water	water	NOUN
dti-1327	153	3	to	to	ADP
dti-1327	153	4	dmso	dmso	ADJ
dti-1327	153	5	ratio	ratio	NOUN
dti-1327	153	6	was	be	AUX
dti-1327	153	7	20:80	20:80	NUM
dti-1327	153	8	.	.	PUNCT
dti-1327	154	1	mass	mass	PROPN
dti-1327	154	2	spectra	spectra	PROPN
dti-1327	154	3	a	a	DET
dti-1327	154	4	maldi	maldi	NOUN
dti-1327	154	5	-	-	PUNCT
dti-1327	154	6	tof	tof	PRON
dti-1327	154	7	mass	mass	NOUN
dti-1327	154	8	spectrum	spectrum	NOUN
dti-1327	154	9	of	of	ADP
dti-1327	154	10	the	the	DET
dti-1327	154	11	commercial	commercial	ADJ
dti-1327	154	12	peg	peg	NOUN
dti-1327	154	13	displayed	display	VERB
dti-1327	154	14	a	a	DET
dti-1327	154	15	mass	mass	ADJ
dti-1327	154	16	range	range	NOUN
dti-1327	154	17	of	of	ADP
dti-1327	154	18	1900–2100	1900–2100	NUM
dti-1327	154	19	m	m	NOUN
dti-1327	154	20	/	/	SYM
dti-1327	154	21	z	z	PROPN
dti-1327	154	22	due	due	ADP
dti-1327	154	23	to	to	ADP
dti-1327	154	24	the	the	DET
dti-1327	154	25	polydispersity	polydispersity	NOUN
dti-1327	154	26	of	of	ADP
dti-1327	154	27	the	the	DET
dti-1327	154	28	polymer	polymer	NOUN
dti-1327	154	29	.	.	PUNCT
dti-1327	155	1	the	the	DET
dti-1327	155	2	observed	observe	VERB
dti-1327	155	3	mass	mass	NOUN
dti-1327	155	4	of	of	ADP
dti-1327	155	5	γ-2	γ-2	NOUN
dti-1327	155	6	is	be	AUX
dti-1327	155	7	centered	center	VERB
dti-1327	155	8	at	at	ADP
dti-1327	155	9	2422	2422	NUM
dti-1327	155	10	m	m	NOUN
dti-1327	155	11	/	/	SYM
dti-1327	155	12	z	z	PROPN
dti-1327	155	13	in	in	ADP
dti-1327	155	14	agreement	agreement	NOUN
dti-1327	155	15	with	with	ADP
dti-1327	155	16	the	the	DET
dti-1327	155	17	calculated	calculated	ADJ
dti-1327	155	18	theoretical	theoretical	ADJ
dti-1327	155	19	mass	mass	NOUN
dti-1327	155	20	of	of	ADP
dti-1327	155	21	~	~	PUNCT
dti-1327	155	22	2400	2400	NUM
dti-1327	155	23	m	m	PROPN
dti-1327	155	24	/	/	SYM
dti-1327	155	25	z	z	PROPN
dti-1327	155	26	for	for	ADP
dti-1327	155	27	the	the	DET
dti-1327	155	28	polydisperse	polydisperse	NOUN
dti-1327	155	29	peg	peg	NOUN
dti-1327	155	30	containing	contain	VERB
dti-1327	155	31	system	system	NOUN
dti-1327	155	32	.	.	PUNCT
dti-1327	156	1	the	the	DET
dti-1327	156	2	calculated	calculated	ADJ
dti-1327	156	3	theoretical	theoretical	ADJ
dti-1327	156	4	mass	mass	NOUN
dti-1327	156	5	of	of	ADP
dti-1327	156	6	γ-4	γ-4	NOUN
dti-1327	156	7	is	be	AUX
dti-1327	156	8	~	~	PUNCT
dti-1327	156	9	2900	2900	NUM
dti-1327	156	10	m	m	NOUN
dti-1327	156	11	/	/	SYM
dti-1327	156	12	z.	z.	PROPN
dti-1327	156	13	a	a	DET
dti-1327	156	14	central	central	ADJ
dti-1327	156	15	range	range	NOUN
dti-1327	156	16	at	at	ADP
dti-1327	156	17	2846	2846	NUM
dti-1327	156	18	m	m	NOUN
dti-1327	156	19	/	/	SYM
dti-1327	156	20	z	z	PROPN
dti-1327	156	21	was	be	AUX
dti-1327	156	22	observed	observe	VERB
dti-1327	156	23	from	from	ADP
dti-1327	156	24	maldi	maldi	NOUN
dti-1327	156	25	-	-	PUNCT
dti-1327	156	26	tof	tof	PRON
dti-1327	156	27	mass	mass	ADJ
dti-1327	156	28	spectrometry	spectrometry	NOUN
dti-1327	156	29	analysis	analysis	NOUN
dti-1327	156	30	.	.	PUNCT
dti-1327	157	1	the	the	DET
dti-1327	157	2	44	44	NUM
dti-1327	157	3	m	m	NOUN
dti-1327	157	4	/	/	SYM
dti-1327	157	5	z	z	NOUN
dti-1327	157	6	spacing	spacing	NOUN
dti-1327	157	7	is	be	AUX
dti-1327	157	8	indicative	indicative	ADJ
dti-1327	157	9	of	of	ADP
dti-1327	157	10	one	one	NUM
dti-1327	157	11	unit	unit	NOUN
dti-1327	157	12	of	of	ADP
dti-1327	157	13	ethylene	ethylene	NOUN
dti-1327	157	14	glycol	glycol	NOUN
dti-1327	157	15	(	(	PUNCT
dti-1327	157	16	mw	mw	NOUN
dti-1327	157	17	:	:	PUNCT
dti-1327	157	18	44	44	NUM
dti-1327	157	19	g	g	NOUN
dti-1327	157	20	/	/	SYM
dti-1327	157	21	mol	mol	NOUN
dti-1327	157	22	)	)	PUNCT
dti-1327	157	23	.	.	PUNCT
dti-1327	158	1	figure	figure	NOUN
dti-1327	158	2	3a	3a	NUM
dti-1327	158	3	–	–	PUNCT
dti-1327	158	4	b	b	NOUN
dti-1327	158	5	displays	display	VERB
dti-1327	158	6	the	the	DET
dti-1327	158	7	mass	mass	ADJ
dti-1327	158	8	spectra	spectra	NOUN
dti-1327	158	9	obtained	obtain	VERB
dti-1327	158	10	for	for	ADP
dti-1327	158	11	γ-2	γ-2	NOUN
dti-1327	158	12	and	and	CCONJ
dti-1327	158	13	γ-4	γ-4	NOUN
dti-1327	158	14	respectively	respectively	ADV
dti-1327	158	15	.	.	PUNCT
dti-1327	159	1	in	in	ADP
dti-1327	159	2	vitro	vitro	X
dti-1327	159	3	biological	biological	ADJ
dti-1327	159	4	activity	activity	NOUN
dti-1327	159	5	ic50	ic50	PROPN
dti-1327	159	6	concentrations	concentration	NOUN
dti-1327	159	7	were	be	AUX
dti-1327	159	8	calculated	calculate	VERB
dti-1327	159	9	using	use	VERB
dti-1327	159	10	an	an	DET
dti-1327	159	11	exponential	exponential	ADJ
dti-1327	159	12	fi	fi	NOUN
dti-1327	159	13	t.	t.	NOUN
dti-1327	159	14	table	table	NOUN
dti-1327	159	15	2	2	NUM
dti-1327	159	16	shows	show	VERB
dti-1327	159	17	the	the	DET
dti-1327	159	18	potency	potency	NOUN
dti-1327	159	19	of	of	ADP
dti-1327	159	20	1	1	NUM
dti-1327	159	21	,	,	PUNCT
dti-1327	159	22	γ-2	γ-2	PROPN
dti-1327	159	23	,	,	PUNCT
dti-1327	159	24	γ-3	γ-3	PROPN
dti-1327	159	25	,	,	PUNCT
dti-1327	159	26	scheme	scheme	NOUN
dti-1327	159	27	1	1	NUM
dti-1327	159	28	.	.	PUNCT
dti-1327	160	1	synthesis	synthesis	NOUN
dti-1327	160	2	of	of	ADP
dti-1327	160	3	1	1	NUM
dti-1327	160	4	involving	involve	VERB
dti-1327	160	5	chelation	chelation	NOUN
dti-1327	160	6	of	of	ADP
dti-1327	160	7	ga(iii	ga(iii	NOUN
dti-1327	160	8	)	)	PUNCT
dti-1327	160	9	to	to	ADP
dti-1327	160	10	dota	dota	VERB
dti-1327	160	11	in	in	ADP
dti-1327	160	12	ammonium	ammonium	NOUN
dti-1327	160	13	acetate	acetate	NOUN
dti-1327	160	14	buffer	buffer	NOUN
dti-1327	160	15	(	(	PUNCT
dti-1327	160	16	ph	ph	NOUN
dti-1327	160	17	4.8	4.8	NUM
dti-1327	160	18	)	)	PUNCT
dti-1327	160	19	.	.	PUNCT
dti-1327	161	1	18	18	NUM
dti-1327	161	2	viola	viola	PROPN
dti-1327	161	3	-	-	PUNCT
dti-1327	161	4	villegas	villegas	PROPN
dti-1327	161	5	et	et	PROPN
dti-1327	161	6	al	al	PROPN
dti-1327	161	7	drug	drug	PROPN
dti-1327	161	8	target	target	NOUN
dti-1327	161	9	insights	insight	NOUN
dti-1327	161	10	2008:3	2008:3	NUM
dti-1327	161	11	scheme	scheme	NOUN
dti-1327	161	12	2	2	NUM
dti-1327	161	13	.	.	PUNCT
dti-1327	161	14	synthesis	synthesis	NOUN
dti-1327	161	15	and	and	CCONJ
dti-1327	161	16	separation	separation	NOUN
dti-1327	161	17	,	,	PUNCT
dti-1327	161	18	via	via	ADP
dti-1327	161	19	iec	iec	NOUN
dti-1327	161	20	of	of	ADP
dti-1327	161	21	the	the	DET
dti-1327	161	22	regioisomers	regioisomer	NOUN
dti-1327	161	23	of	of	ADP
dti-1327	161	24	the	the	DET
dti-1327	161	25	αand	αand	ADV
dti-1327	161	26	γ	γ	NOUN
dti-1327	161	27	-	-	PUNCT
dti-1327	161	28	isomers	isomer	NOUN
dti-1327	161	29	of	of	ADP
dti-1327	161	30	2	2	NUM
dti-1327	161	31	.	.	PUNCT
dti-1327	161	32	scheme	scheme	NOUN
dti-1327	161	33	3	3	NUM
dti-1327	161	34	.	.	PUNCT
dti-1327	161	35	synthesis	synthesis	NOUN
dti-1327	161	36	of	of	ADP
dti-1327	161	37	γ-3	γ-3	NOUN
dti-1327	161	38	using	use	VERB
dti-1327	161	39	edc	edc	PROPN
dti-1327	161	40	/	/	SYM
dti-1327	161	41	sulfo	sulfo	PROPN
dti-1327	161	42	-	-	PUNCT
dti-1327	161	43	nhs	nhs	PROPN
dti-1327	161	44	as	as	ADP
dti-1327	161	45	coupling	couple	VERB
dti-1327	161	46	agents	agent	NOUN
dti-1327	161	47	.	.	PUNCT
dti-1327	162	1	19	19	NUM
dti-1327	162	2	targeting	target	VERB
dti-1327	162	3	gallium	gallium	NOUN
dti-1327	162	4	to	to	ADP
dti-1327	162	5	cancer	cancer	NOUN
dti-1327	162	6	cells	cell	NOUN
dti-1327	162	7	through	through	ADP
dti-1327	162	8	the	the	DET
dti-1327	162	9	folate	folate	NOUN
dti-1327	162	10	receptor	receptor	NOUN
dti-1327	162	11	drug	drug	NOUN
dti-1327	162	12	target	target	NOUN
dti-1327	162	13	insights	insight	NOUN
dti-1327	162	14	2008:3	2008:3	NUM
dti-1327	162	15	γ-4	γ-4	ADJ
dti-1327	162	16	and	and	CCONJ
dti-1327	162	17	dota	dota	PROPN
dti-1327	162	18	against	against	ADP
dti-1327	162	19	both	both	DET
dti-1327	162	20	the	the	DET
dti-1327	162	21	a2780	a2780	NOUN
dti-1327	162	22	/	/	SYM
dti-1327	162	23	ad	ad	NOUN
dti-1327	162	24	and	and	CCONJ
dti-1327	162	25	cho	cho	NOUN
dti-1327	162	26	cell	cell	NOUN
dti-1327	162	27	lines	line	NOUN
dti-1327	162	28	.	.	PUNCT
dti-1327	163	1	azt	azt	PROPN
dti-1327	163	2	was	be	AUX
dti-1327	163	3	used	use	VERB
dti-1327	163	4	as	as	ADP
dti-1327	163	5	an	an	DET
dti-1327	163	6	internal	internal	ADJ
dti-1327	163	7	control	control	NOUN
dti-1327	163	8	(	(	PUNCT
dti-1327	163	9	data	datum	NOUN
dti-1327	163	10	not	not	PART
dti-1327	163	11	shown	show	VERB
dti-1327	163	12	)	)	PUNCT
dti-1327	163	13	.	.	PUNCT
dti-1327	164	1	in	in	ADP
dti-1327	164	2	all	all	DET
dti-1327	164	3	cases	case	NOUN
dti-1327	164	4	toxicity	toxicity	NOUN
dti-1327	164	5	was	be	AUX
dti-1327	164	6	greater	great	ADJ
dti-1327	164	7	in	in	ADP
dti-1327	164	8	the	the	DET
dti-1327	164	9	a2780	a2780	NOUN
dti-1327	164	10	/	/	SYM
dti-1327	164	11	ad	ad	NOUN
dti-1327	164	12	line	line	NOUN
dti-1327	164	13	over	over	ADP
dti-1327	164	14	the	the	DET
dti-1327	164	15	cho	cho	PROPN
dti-1327	164	16	line	line	NOUN
dti-1327	164	17	.	.	PUNCT
dti-1327	165	1	1	1	NUM
dti-1327	165	2	,	,	PUNCT
dti-1327	165	3	γ-3	γ-3	PROPN
dti-1327	165	4	,	,	PUNCT
dti-1327	165	5	γ-4	γ-4	PROPN
dti-1327	165	6	and	and	CCONJ
dti-1327	165	7	dota	dota	PROPN
dti-1327	165	8	displayed	display	VERB
dti-1327	165	9	between	between	ADP
dti-1327	165	10	[	[	X
dti-1327	165	11	0.18	0.18	NUM
dti-1327	165	12	and	and	CCONJ
dti-1327	165	13	1.85	1.85	NUM
dti-1327	165	14	mm	mm	NOUN
dti-1327	165	15	]	]	X
dti-1327	165	16	activity	activity	NOUN
dti-1327	165	17	against	against	ADP
dti-1327	165	18	a2780	a2780	NOUN
dti-1327	165	19	/	/	SYM
dti-1327	165	20	ad	ad	NOUN
dti-1327	165	21	cells	cell	NOUN
dti-1327	165	22	and	and	CCONJ
dti-1327	165	23	between	between	ADP
dti-1327	165	24	[	[	X
dti-1327	165	25	0.8	0.8	NUM
dti-1327	165	26	and	and	CCONJ
dti-1327	165	27	2.93	2.93	NUM
dti-1327	165	28	mm	mm	NOUN
dti-1327	165	29	]	]	PUNCT
dti-1327	165	30	in	in	ADP
dti-1327	165	31	cho	cho	NOUN
dti-1327	165	32	cells	cell	NOUN
dti-1327	165	33	.	.	PUNCT
dti-1327	166	1	γ-2	γ-2	NOUN
dti-1327	166	2	provided	provide	VERB
dti-1327	166	3	no	no	DET
dti-1327	166	4	ic50	ic50	PROPN
dti-1327	166	5	concentration	concentration	NOUN
dti-1327	166	6	over	over	ADP
dti-1327	166	7	72	72	NUM
dti-1327	166	8	hours	hour	NOUN
dti-1327	166	9	at	at	ADP
dti-1327	166	10	concentrations	concentration	NOUN
dti-1327	166	11	up	up	ADP
dti-1327	166	12	to	to	ADP
dti-1327	166	13	[	[	X
dti-1327	166	14	100	100	NUM
dti-1327	166	15	mm	mm	NOUN
dti-1327	166	16	]	]	X
dti-1327	166	17	.	.	PUNCT
dti-1327	167	1	the	the	DET
dti-1327	167	2	fact	fact	NOUN
dti-1327	167	3	that	that	SCONJ
dti-1327	167	4	the	the	DET
dti-1327	167	5	fa	fa	NOUN
dti-1327	167	6	-	-	PUNCT
dti-1327	167	7	peg	peg	NOUN
dti-1327	167	8	moiety	moiety	NOUN
dti-1327	167	9	is	be	AUX
dti-1327	167	10	not	not	PART
dti-1327	167	11	toxic	toxic	ADJ
dti-1327	167	12	indicates	indicate	VERB
dti-1327	167	13	that	that	SCONJ
dti-1327	167	14	the	the	DET
dti-1327	167	15	activity	activity	NOUN
dti-1327	167	16	of	of	ADP
dti-1327	167	17	the	the	DET
dti-1327	167	18	completed	complete	VERB
dti-1327	167	19	conjugates	conjugate	NOUN
dti-1327	167	20	stems	stem	VERB
dti-1327	167	21	from	from	ADP
dti-1327	167	22	the	the	DET
dti-1327	167	23	gallium	gallium	NOUN
dti-1327	167	24	metal	metal	NOUN
dti-1327	167	25	or	or	CCONJ
dti-1327	167	26	dota	dota	PROPN
dti-1327	167	27	ligand	ligand	NOUN
dti-1327	167	28	itself	itself	PRON
dti-1327	167	29	.	.	PUNCT
dti-1327	168	1	interestingly	interestingly	ADV
dti-1327	168	2	gallium	gallium	NOUN
dti-1327	168	3	compounds	compound	NOUN
dti-1327	168	4	were	be	AUX
dti-1327	168	5	noted	note	VERB
dti-1327	168	6	as	as	ADP
dti-1327	168	7	less	less	ADV
dti-1327	168	8	toxic	toxic	ADJ
dti-1327	168	9	than	than	ADP
dti-1327	168	10	free	free	ADJ
dti-1327	168	11	dota	dota	PROPN
dti-1327	168	12	containing	contain	VERB
dti-1327	168	13	controls	control	NOUN
dti-1327	168	14	.	.	PUNCT
dti-1327	169	1	this	this	PRON
dti-1327	169	2	was	be	AUX
dti-1327	169	3	the	the	DET
dti-1327	169	4	case	case	NOUN
dti-1327	169	5	in	in	ADP
dti-1327	169	6	both	both	DET
dti-1327	169	7	cell	cell	NOUN
dti-1327	169	8	lines	line	NOUN
dti-1327	169	9	.	.	PUNCT
dti-1327	170	1	the	the	DET
dti-1327	170	2	ic50	ic50	PROPN
dti-1327	170	3	concentrations	concentration	NOUN
dti-1327	170	4	for	for	ADP
dti-1327	170	5	both	both	DET
dti-1327	170	6	compounds	compound	NOUN
dti-1327	170	7	containing	contain	VERB
dti-1327	170	8	gallium	gallium	NOUN
dti-1327	170	9	(	(	PUNCT
dti-1327	170	10	namely	namely	ADV
dti-1327	170	11	1	1	NUM
dti-1327	170	12	and	and	CCONJ
dti-1327	170	13	γ-4	γ-4	NOUN
dti-1327	170	14	)	)	PUNCT
dti-1327	170	15	indicate	indicate	VERB
dti-1327	170	16	that	that	DET
dti-1327	170	17	gallium	gallium	NOUN
dti-1327	170	18	is	be	AUX
dti-1327	170	19	in	in	ADP
dti-1327	170	20	fact	fact	NOUN
dti-1327	170	21	reducing	reduce	VERB
dti-1327	170	22	the	the	DET
dti-1327	170	23	toxicity	toxicity	NOUN
dti-1327	170	24	of	of	ADP
dti-1327	170	25	the	the	DET
dti-1327	170	26	dota	dota	PROPN
dti-1327	170	27	moiety	moiety	NOUN
dti-1327	170	28	,	,	PUNCT
dti-1327	170	29	presumably	presumably	ADV
dti-1327	170	30	by	by	ADP
dti-1327	170	31	chelation	chelation	NOUN
dti-1327	170	32	,	,	PUNCT
dti-1327	170	33	hence	hence	ADV
dti-1327	170	34	preventing	prevent	VERB
dti-1327	170	35	the	the	DET
dti-1327	170	36	scavenging	scavenging	NOUN
dti-1327	170	37	by	by	ADP
dti-1327	170	38	dota	dota	PROPN
dti-1327	170	39	of	of	ADP
dti-1327	170	40	other	other	ADJ
dti-1327	170	41	essential	essential	ADJ
dti-1327	170	42	metals	metal	NOUN
dti-1327	170	43	.	.	PUNCT
dti-1327	171	1	toxicity	toxicity	NOUN
dti-1327	171	2	of	of	ADP
dti-1327	171	3	the	the	DET
dti-1327	171	4	fa	fa	NOUN
dti-1327	171	5	-	-	NOUN
dti-1327	171	6	peg	peg	NOUN
dti-1327	171	7	containing	contain	VERB
dti-1327	171	8	dota	dota	PROPN
dti-1327	171	9	compound	compound	PROPN
dti-1327	171	10	(	(	PUNCT
dti-1327	171	11	γ-3	γ-3	PROPN
dti-1327	171	12	)	)	PUNCT
dti-1327	171	13	against	against	ADP
dti-1327	171	14	cho	cho	NOUN
dti-1327	171	15	cells	cell	NOUN
dti-1327	171	16	can	can	AUX
dti-1327	171	17	then	then	ADV
dti-1327	171	18	also	also	ADV
dti-1327	171	19	be	be	AUX
dti-1327	171	20	explained	explain	VERB
dti-1327	171	21	as	as	ADP
dti-1327	171	22	metal	metal	NOUN
dti-1327	171	23	scavenging	scavenge	VERB
dti-1327	171	24	outside	outside	ADP
dti-1327	171	25	the	the	DET
dti-1327	171	26	cell	cell	NOUN
dti-1327	171	27	,	,	PUNCT
dti-1327	171	28	with	with	ADP
dti-1327	171	29	uptake	uptake	ADJ
dti-1327	171	30	not	not	PART
dti-1327	171	31	necessary	necessary	ADJ
dti-1327	171	32	(	(	PUNCT
dti-1327	171	33	and	and	CCONJ
dti-1327	171	34	not	not	PART
dti-1327	171	35	possible	possible	ADJ
dti-1327	171	36	in	in	ADP
dti-1327	171	37	cho	cho	NOUN
dti-1327	171	38	without	without	ADP
dti-1327	171	39	the	the	DET
dti-1327	171	40	fr	fr	NOUN
dti-1327	171	41	)	)	PUNCT
dti-1327	171	42	.	.	PUNCT
dti-1327	172	1	dota	dota	PROPN
dti-1327	172	2	and	and	CCONJ
dti-1327	172	3	γ-3	γ-3	PROPN
dti-1327	172	4	displayed	display	VERB
dti-1327	172	5	ic50	ic50	PROPN
dti-1327	172	6	concentrations	concentration	NOUN
dti-1327	172	7	of	of	ADP
dti-1327	172	8	800	800	NUM
dti-1327	172	9	µm	µm	NOUN
dti-1327	172	10	and	and	CCONJ
dti-1327	172	11	1.35	1.35	NUM
dti-1327	172	12	mm	mm	NOUN
dti-1327	172	13	against	against	ADP
dti-1327	172	14	cho	cho	NOUN
dti-1327	172	15	and	and	CCONJ
dti-1327	172	16	580	580	NUM
dti-1327	172	17	µm	µm	NOUN
dti-1327	172	18	and	and	CCONJ
dti-1327	172	19	180	180	NUM
dti-1327	172	20	µm	µm	NOUN
dti-1327	172	21	against	against	ADP
dti-1327	172	22	a2780	a2780	NOUN
dti-1327	172	23	/	/	SYM
dti-1327	172	24	ad	ad	NOUN
dti-1327	172	25	cell	cell	NOUN
dti-1327	172	26	lines	line	NOUN
dti-1327	172	27	respectively	respectively	ADV
dti-1327	172	28	.	.	PUNCT
dti-1327	173	1	the	the	DET
dti-1327	173	2	presence	presence	NOUN
dti-1327	173	3	of	of	ADP
dti-1327	173	4	the	the	DET
dti-1327	173	5	fr	fr	ADJ
dti-1327	173	6	receptor	receptor	NOUN
dti-1327	173	7	in	in	ADP
dti-1327	173	8	a2780	a2780	NOUN
dti-1327	173	9	/	/	SYM
dti-1327	173	10	ad	ad	NOUN
dti-1327	173	11	and	and	CCONJ
dti-1327	173	12	more	more	ADV
dti-1327	173	13	rapid	rapid	ADJ
dti-1327	173	14	division	division	NOUN
dti-1327	173	15	in	in	ADP
dti-1327	173	16	a2780	a2780	NOUN
dti-1327	173	17	/	/	SYM
dti-1327	173	18	ad	ad	NOUN
dti-1327	173	19	over	over	ADP
dti-1327	173	20	cho	cho	PROPN
dti-1327	173	21	helps	help	VERB
dti-1327	173	22	explain	explain	VERB
dti-1327	173	23	the	the	DET
dti-1327	173	24	greater	great	ADJ
dti-1327	173	25	toxicity	toxicity	NOUN
dti-1327	173	26	.	.	PUNCT
dti-1327	174	1	toxicity	toxicity	NOUN
dti-1327	174	2	of	of	ADP
dti-1327	174	3	γ-4	γ-4	NOUN
dti-1327	174	4	in	in	ADP
dti-1327	174	5	cho	cho	PROPN
dti-1327	174	6	cells	cell	NOUN
dti-1327	174	7	was	be	AUX
dti-1327	174	8	noted	note	VERB
dti-1327	174	9	as	as	ADP
dti-1327	174	10	2.93	2.93	NUM
dti-1327	174	11	mm	mm	NOUN
dti-1327	174	12	and	and	CCONJ
dti-1327	174	13	1.85	1.85	NUM
dti-1327	174	14	mm	mm	NOUN
dti-1327	174	15	in	in	ADP
dti-1327	174	16	a2780	a2780	ADJ
dti-1327	174	17	/	/	SYM
dti-1327	174	18	ad	ad	NOUN
dti-1327	174	19	cells	cell	NOUN
dti-1327	174	20	.	.	PUNCT
dti-1327	175	1	the	the	DET
dti-1327	175	2	reduced	reduced	ADJ
dti-1327	175	3	toxicity	toxicity	NOUN
dti-1327	175	4	of	of	ADP
dti-1327	175	5	the	the	DET
dti-1327	175	6	dota	dota	PROPN
dti-1327	175	7	compounds	compound	VERB
dti-1327	175	8	previously	previously	ADV
dti-1327	175	9	complexed	complexe	VERB
dti-1327	175	10	with	with	ADP
dti-1327	175	11	gallium	gallium	NOUN
dti-1327	175	12	is	be	AUX
dti-1327	175	13	consistent	consistent	ADJ
dti-1327	175	14	with	with	ADP
dti-1327	175	15	the	the	DET
dti-1327	175	16	observed	observe	VERB
dti-1327	175	17	toxicity	toxicity	NOUN
dti-1327	175	18	of	of	ADP
dti-1327	175	19	free	free	ADJ
dti-1327	175	20	dota	dota	PROPN
dti-1327	175	21	and	and	CCONJ
dti-1327	175	22	supports	support	VERB
dti-1327	175	23	the	the	DET
dti-1327	175	24	idea	idea	NOUN
dti-1327	175	25	that	that	SCONJ
dti-1327	175	26	the	the	DET
dti-1327	175	27	toxicity	toxicity	NOUN
dti-1327	175	28	lies	lie	VERB
dti-1327	175	29	with	with	ADP
dti-1327	175	30	metal	metal	NOUN
dti-1327	175	31	scavenging	scavenging	NOUN
dti-1327	175	32	by	by	ADP
dti-1327	175	33	dota	dota	NOUN
dti-1327	175	34	and	and	CCONJ
dti-1327	175	35	supercedes	supercede	VERB
dti-1327	175	36	any	any	DET
dti-1327	175	37	gallium	gallium	NOUN
dti-1327	175	38	related	relate	VERB
dti-1327	175	39	toxicity	toxicity	NOUN
dti-1327	175	40	.	.	PUNCT
dti-1327	176	1	the	the	DET
dti-1327	176	2	toxicity	toxicity	NOUN
dti-1327	176	3	in	in	ADP
dti-1327	176	4	cho	cho	NOUN
dti-1327	176	5	cells	cell	NOUN
dti-1327	176	6	can	can	AUX
dti-1327	176	7	only	only	ADV
dti-1327	176	8	be	be	AUX
dti-1327	176	9	explained	explain	VERB
dti-1327	176	10	then	then	ADV
dti-1327	176	11	if	if	SCONJ
dti-1327	176	12	gallium	gallium	NOUN
dti-1327	176	13	is	be	AUX
dti-1327	176	14	leaching	leach	VERB
dti-1327	176	15	from	from	ADP
dti-1327	176	16	the	the	DET
dti-1327	176	17	dota	dota	PROPN
dti-1327	176	18	macrocyle	macrocyle	NOUN
dti-1327	176	19	,	,	PUNCT
dti-1327	176	20	since	since	SCONJ
dti-1327	176	21	this	this	PRON
dti-1327	176	22	would	would	AUX
dti-1327	176	23	produce	produce	VERB
dti-1327	176	24	a	a	DET
dti-1327	176	25	gallium	gallium	NOUN
dti-1327	176	26	salt	salt	NOUN
dti-1327	176	27	or	or	CCONJ
dti-1327	176	28	complex	complex	ADJ
dti-1327	176	29	and	and	CCONJ
dti-1327	176	30	would	would	AUX
dti-1327	176	31	leave	leave	VERB
dti-1327	176	32	dota	dota	PROPN
dti-1327	176	33	now	now	ADV
dti-1327	176	34	uncomplexed	uncomplexe	VERB
dti-1327	176	35	and	and	CCONJ
dti-1327	176	36	free	free	ADJ
dti-1327	176	37	to	to	PART
dti-1327	176	38	chelate	chelate	VERB
dti-1327	176	39	other	other	ADJ
dti-1327	176	40	metals	metal	NOUN
dti-1327	176	41	.	.	PUNCT
dti-1327	177	1	gallium	gallium	NOUN
dti-1327	177	2	decomplexation	decomplexation	NOUN
dti-1327	177	3	from	from	ADP
dti-1327	177	4	a	a	DET
dti-1327	177	5	ligand	ligand	NOUN
dti-1327	177	6	such	such	ADJ
dti-1327	177	7	as	as	ADP
dti-1327	177	8	dota	dota	PROPN
dti-1327	177	9	that	that	PRON
dti-1327	177	10	renders	render	VERB
dti-1327	177	11	such	such	ADJ
dti-1327	177	12	thermodynamic	thermodynamic	ADJ
dti-1327	177	13	and	and	CCONJ
dti-1327	177	14	kinetic	kinetic	ADJ
dti-1327	177	15	stability	stability	NOUN
dti-1327	177	16	is	be	AUX
dti-1327	177	17	possible	possible	ADJ
dti-1327	177	18	even	even	ADV
dti-1327	177	19	with	with	ADP
dti-1327	177	20	a	a	DET
dti-1327	177	21	reported	report	VERB
dti-1327	177	22	stability	stability	NOUN
dti-1327	177	23	constant	constant	ADJ
dti-1327	177	24	of	of	ADP
dti-1327	177	25	log	log	NOUN
dti-1327	177	26	k	k	PROPN
dti-1327	177	27	~	~	PUNCT
dti-1327	177	28	21.33	21.33	NUM
dti-1327	177	29	(	(	PUNCT
dti-1327	177	30	clark	clark	NOUN
dti-1327	177	31	and	and	CCONJ
dti-1327	177	32	martell	martell	PROPN
dti-1327	177	33	,	,	PUNCT
dti-1327	177	34	1991	1991	NUM
dti-1327	177	35	)	)	PUNCT
dti-1327	177	36	(	(	PUNCT
dti-1327	177	37	compared	compare	VERB
dti-1327	177	38	to	to	PART
dti-1327	177	39	say	say	VERB
dti-1327	177	40	to	to	PART
dti-1327	177	41	open	open	VERB
dti-1327	177	42	-	-	PUNCT
dti-1327	177	43	chain	chain	NOUN
dti-1327	177	44	multidentate	multidentate	NOUN
dti-1327	177	45	ligands	ligand	NOUN
dti-1327	177	46	like	like	ADP
dti-1327	177	47	ethylenediamine	ethylenediamine	NOUN
dti-1327	177	48	(	(	PUNCT
dti-1327	177	49	log	log	VERB
dti-1327	177	50	k	k	X
dti-1327	177	51	∼	∼	NOUN
dti-1327	177	52	17.2	17.2	NUM
dti-1327	177	53	)	)	PUNCT
dti-1327	177	54	(	(	PUNCT
dti-1327	177	55	harris	harris	PROPN
dti-1327	177	56	and	and	CCONJ
dti-1327	177	57	martell	martell	PROPN
dti-1327	177	58	,	,	PUNCT
dti-1327	177	59	1976	1976	NUM
dti-1327	177	60	)	)	PUNCT
dti-1327	177	61	)	)	PUNCT
dti-1327	177	62	.	.	PUNCT
dti-1327	178	1	a	a	DET
dti-1327	178	2	key	key	ADJ
dti-1327	178	3	scheme	scheme	NOUN
dti-1327	178	4	4	4	NUM
dti-1327	178	5	.	.	PUNCT
dti-1327	178	6	synthesis	synthesis	NOUN
dti-1327	178	7	of	of	ADP
dti-1327	178	8	γ-4	γ-4	PROPN
dti-1327	178	9	illustrates	illustrate	VERB
dti-1327	178	10	the	the	DET
dti-1327	178	11	coupling	coupling	NOUN
dti-1327	178	12	of	of	ADP
dti-1327	178	13	γ-2	γ-2	NOUN
dti-1327	178	14	and	and	CCONJ
dti-1327	178	15	1	1	NUM
dti-1327	178	16	using	use	VERB
dti-1327	178	17	dcc	dcc	PROPN
dti-1327	178	18	and	and	CCONJ
dti-1327	178	19	nhs	nhs	PROPN
dti-1327	178	20	as	as	ADP
dti-1327	178	21	coupling	couple	VERB
dti-1327	178	22	agents	agent	NOUN
dti-1327	178	23	in	in	ADP
dti-1327	178	24	dry	dry	ADJ
dti-1327	178	25	dmso	dmso	NOUN
dti-1327	178	26	.	.	PROPN
dti-1327	179	1	20	20	NUM
dti-1327	179	2	viola	viola	PROPN
dti-1327	179	3	-	-	PUNCT
dti-1327	179	4	villegas	villegas	PROPN
dti-1327	179	5	et	et	PROPN
dti-1327	179	6	al	al	PROPN
dti-1327	179	7	drug	drug	PROPN
dti-1327	179	8	target	target	NOUN
dti-1327	179	9	insights	insight	NOUN
dti-1327	179	10	2008:3	2008:3	NUM
dti-1327	179	11	factor	factor	NOUN
dti-1327	179	12	in	in	ADP
dti-1327	179	13	this	this	DET
dti-1327	179	14	release	release	NOUN
dti-1327	179	15	is	be	AUX
dti-1327	179	16	an	an	DET
dti-1327	179	17	increase	increase	NOUN
dti-1327	179	18	in	in	ADP
dti-1327	179	19	dota	dota	PROPN
dti-1327	179	20	’s	’s	PART
dti-1327	179	21	electron	electron	NOUN
dti-1327	179	22	density	density	NOUN
dti-1327	179	23	due	due	ADJ
dti-1327	179	24	to	to	ADP
dti-1327	179	25	inductive	inductive	ADJ
dti-1327	179	26	effects	effect	NOUN
dti-1327	179	27	contributed	contribute	VERB
dti-1327	179	28	by	by	ADP
dti-1327	179	29	the	the	DET
dti-1327	179	30	ethylene	ethylene	NOUN
dti-1327	179	31	bridges	bridge	NOUN
dti-1327	179	32	(	(	PUNCT
dti-1327	179	33	hancock	hancock	NOUN
dti-1327	179	34	and	and	CCONJ
dti-1327	179	35	martell	martell	PROPN
dti-1327	179	36	,	,	PUNCT
dti-1327	179	37	1995	1995	NUM
dti-1327	179	38	)	)	PUNCT
dti-1327	179	39	.	.	PUNCT
dti-1327	180	1	a	a	DET
dti-1327	180	2	plausible	plausible	ADJ
dti-1327	180	3	explanation	explanation	NOUN
dti-1327	180	4	for	for	ADP
dti-1327	180	5	the	the	DET
dti-1327	180	6	possibility	possibility	NOUN
dti-1327	180	7	of	of	ADP
dti-1327	180	8	gallium	gallium	NOUN
dti-1327	180	9	release	release	NOUN
dti-1327	180	10	concerns	concern	VERB
dti-1327	180	11	the	the	DET
dti-1327	180	12	formation	formation	NOUN
dti-1327	180	13	of	of	ADP
dti-1327	180	14	the	the	DET
dti-1327	180	15	fa	fa	PROPN
dti-1327	180	16	conjugate	conjugate	NOUN
dti-1327	180	17	.	.	PUNCT
dti-1327	181	1	the	the	DET
dti-1327	181	2	stability	stability	NOUN
dti-1327	181	3	of	of	ADP
dti-1327	181	4	γ-4	γ-4	NOUN
dti-1327	181	5	may	may	AUX
dti-1327	181	6	be	be	AUX
dti-1327	181	7	affected	affect	VERB
dti-1327	181	8	by	by	ADP
dti-1327	181	9	the	the	DET
dti-1327	181	10	conjugation	conjugation	NOUN
dti-1327	181	11	of	of	ADP
dti-1327	181	12	one	one	NUM
dti-1327	181	13	of	of	ADP
dti-1327	181	14	the	the	DET
dti-1327	181	15	pendant	pendant	ADJ
dti-1327	181	16	carboxylate	carboxylate	NOUN
dti-1327	181	17	arms	arm	NOUN
dti-1327	181	18	of	of	ADP
dti-1327	181	19	dota	dota	PROPN
dti-1327	181	20	.	.	PUNCT
dti-1327	182	1	this	this	DET
dti-1327	182	2	phenomenon	phenomenon	NOUN
dti-1327	182	3	has	have	AUX
dti-1327	182	4	been	be	AUX
dti-1327	182	5	observed	observe	VERB
dti-1327	182	6	by	by	ADP
dti-1327	182	7	several	several	ADJ
dti-1327	182	8	investigations	investigation	NOUN
dti-1327	182	9	that	that	PRON
dti-1327	182	10	involve	involve	VERB
dti-1327	182	11	modifi	modifi	NOUN
dti-1327	182	12	cation	cation	NOUN
dti-1327	182	13	of	of	ADP
dti-1327	182	14	the	the	DET
dti-1327	182	15	dota	dota	PROPN
dti-1327	182	16	side	side	NOUN
dti-1327	182	17	arms	arm	NOUN
dti-1327	182	18	.	.	PUNCT
dti-1327	183	1	sherry	sherry	PROPN
dti-1327	183	2	et	et	PROPN
dti-1327	183	3	al	al	PROPN
dti-1327	183	4	.	.	PROPN
dti-1327	184	1	in	in	ADP
dti-1327	184	2	their	their	PRON
dti-1327	184	3	work	work	NOUN
dti-1327	184	4	involving	involve	VERB
dti-1327	184	5	gadolinium	gadolinium	NOUN
dti-1327	184	6	-	-	PUNCT
dti-1327	184	7	dota	dota	NOUN
dti-1327	184	8	conjugated	conjugate	VERB
dti-1327	184	9	to	to	ADP
dti-1327	184	10	a	a	DET
dti-1327	184	11	propylamide	propylamide	NOUN
dti-1327	184	12	group	group	NOUN
dti-1327	184	13	via	via	ADP
dti-1327	184	14	one	one	NUM
dti-1327	184	15	carboxylate	carboxylate	NOUN
dti-1327	184	16	arm	arm	NOUN
dti-1327	184	17	has	have	AUX
dti-1327	184	18	reported	report	VERB
dti-1327	184	19	a	a	DET
dti-1327	184	20	stability	stability	NOUN
dti-1327	184	21	constant	constant	ADJ
dti-1327	184	22	that	that	PRON
dti-1327	184	23	is	be	AUX
dti-1327	184	24	considerably	considerably	ADV
dti-1327	184	25	lower	low	ADJ
dti-1327	184	26	(	(	PUNCT
dti-1327	184	27	105	105	NUM
dti-1327	184	28	fold	fold	NOUN
dti-1327	184	29	)	)	PUNCT
dti-1327	184	30	than	than	ADP
dti-1327	184	31	the	the	DET
dti-1327	184	32	dota	dota	PROPN
dti-1327	184	33	complex	complex	NOUN
dti-1327	184	34	owing	owe	VERB
dti-1327	184	35	to	to	ADP
dti-1327	184	36	the	the	DET
dti-1327	184	37	decrease	decrease	NOUN
dti-1327	184	38	in	in	ADP
dti-1327	184	39	basicity	basicity	NOUN
dti-1327	184	40	of	of	ADP
dti-1327	184	41	the	the	DET
dti-1327	184	42	amine	amine	ADJ
dti-1327	184	43	macrocycles	macrocycle	NOUN
dti-1327	184	44	(	(	PUNCT
dti-1327	184	45	sherry	sherry	PROPN
dti-1327	184	46	et	et	PROPN
dti-1327	184	47	al	al	PROPN
dti-1327	184	48	.	.	PROPN
dti-1327	184	49	1989	1989	NUM
dti-1327	184	50	)	)	PUNCT
dti-1327	184	51	.	.	PUNCT
dti-1327	185	1	a	a	DET
dti-1327	185	2	recent	recent	ADJ
dti-1327	185	3	investigation	investigation	NOUN
dti-1327	185	4	reported	report	VERB
dti-1327	185	5	that	that	SCONJ
dti-1327	185	6	substitution	substitution	NOUN
dti-1327	185	7	with	with	ADP
dti-1327	185	8	a	a	DET
dti-1327	185	9	p	p	NOUN
dti-1327	185	10	-	-	PUNCT
dti-1327	185	11	no2	no2	NOUN
dti-1327	185	12	-	-	PUNCT
dti-1327	185	13	benzyl	benzyl	NOUN
dti-1327	185	14	group	group	NOUN
dti-1327	185	15	at	at	ADP
dti-1327	185	16	either	either	DET
dti-1327	185	17	one	one	NUM
dti-1327	185	18	of	of	ADP
dti-1327	185	19	the	the	DET
dti-1327	185	20	dota	dota	PROPN
dti-1327	185	21	arms	arm	NOUN
dti-1327	185	22	resulted	result	VERB
dti-1327	185	23	in	in	ADP
dti-1327	185	24	a	a	DET
dti-1327	185	25	reduction	reduction	NOUN
dti-1327	185	26	in	in	ADP
dti-1327	185	27	the	the	DET
dti-1327	185	28	cooperative	cooperative	ADJ
dti-1327	185	29	binding	binding	NOUN
dti-1327	185	30	of	of	ADP
dti-1327	185	31	the	the	DET
dti-1327	185	32	ligand	ligand	NOUN
dti-1327	185	33	and	and	CCONJ
dti-1327	185	34	a	a	DET
dti-1327	185	35	lower	low	ADJ
dti-1327	185	36	thermodynamic	thermodynamic	ADJ
dti-1327	185	37	stability	stability	NOUN
dti-1327	185	38	constant	constant	ADJ
dti-1327	185	39	compared	compare	VERB
dti-1327	185	40	to	to	ADP
dti-1327	185	41	unmodifi	unmodifi	PROPN
dti-1327	185	42	ed	ed	PROPN
dti-1327	185	43	metaldota	metaldota	NOUN
dti-1327	185	44	complex	complex	NOUN
dti-1327	185	45	(	(	PUNCT
dti-1327	185	46	sherry	sherry	PROPN
dti-1327	185	47	et	et	PROPN
dti-1327	185	48	al	al	PROPN
dti-1327	185	49	.	.	PROPN
dti-1327	185	50	2004	2004	NUM
dti-1327	185	51	)	)	PUNCT
dti-1327	185	52	.	.	PUNCT
dti-1327	186	1	of	of	ADP
dti-1327	186	2	course	course	NOUN
dti-1327	186	3	thermodynamic	thermodynamic	ADJ
dti-1327	186	4	stability	stability	NOUN
dti-1327	186	5	does	do	AUX
dti-1327	186	6	not	not	PART
dti-1327	186	7	necessarily	necessarily	ADV
dti-1327	186	8	translate	translate	VERB
dti-1327	186	9	into	into	ADP
dti-1327	186	10	in	in	ADP
dti-1327	186	11	vivo	vivo	ADJ
dti-1327	186	12	stability	stability	NOUN
dti-1327	186	13	with	with	ADP
dti-1327	186	14	kinetic	kinetic	ADJ
dti-1327	186	15	inertness	inertness	NOUN
dti-1327	186	16	often	often	ADV
dti-1327	186	17	being	be	AUX
dti-1327	186	18	of	of	ADP
dti-1327	186	19	greater	great	ADJ
dti-1327	186	20	importance	importance	NOUN
dti-1327	186	21	.	.	PUNCT
dti-1327	187	1	this	this	PRON
dti-1327	187	2	may	may	AUX
dti-1327	187	3	also	also	ADV
dti-1327	187	4	have	have	VERB
dti-1327	187	5	a	a	DET
dti-1327	187	6	role	role	NOUN
dti-1327	187	7	to	to	PART
dti-1327	187	8	play	play	VERB
dti-1327	187	9	in	in	ADP
dti-1327	187	10	gallum	gallum	NOUN
dti-1327	187	11	’s	’s	PART
dti-1327	187	12	release	release	NOUN
dti-1327	187	13	.	.	PUNCT
dti-1327	188	1	structural	structural	ADJ
dti-1327	188	2	studies	study	NOUN
dti-1327	188	3	by	by	ADP
dti-1327	188	4	csajbok	csajbok	PROPN
dti-1327	188	5	et	et	PROPN
dti-1327	188	6	al	al	PROPN
dti-1327	188	7	.	.	PROPN
dti-1327	188	8	via	via	ADP
dti-1327	188	9	1h	1h	NUM
dti-1327	188	10	nmr	nmr	NOUN
dti-1327	188	11	reveal	reveal	VERB
dti-1327	188	12	the	the	DET
dti-1327	188	13	occurrence	occurrence	NOUN
dti-1327	188	14	of	of	ADP
dti-1327	188	15	ring	ring	NOUN
dti-1327	188	16	inversion	inversion	NOUN
dti-1327	188	17	and	and	CCONJ
dti-1327	188	18	fl	fl	NOUN
dti-1327	188	19	uxionality	uxionality	NOUN
dti-1327	188	20	in	in	ADP
dti-1327	188	21	dota	dota	PROPN
dti-1327	188	22	with	with	ADP
dti-1327	188	23	an	an	DET
dti-1327	188	24	increase	increase	NOUN
dti-1327	188	25	in	in	ADP
dti-1327	188	26	temperature	temperature	NOUN
dti-1327	188	27	(	(	PUNCT
dti-1327	188	28	a	a	NOUN
dti-1327	188	29	)	)	PUNCT
dti-1327	188	30	(	(	PUNCT
dti-1327	188	31	b	b	X
dti-1327	188	32	)	)	PUNCT
dti-1327	188	33	figure	figure	NOUN
dti-1327	188	34	3	3	NUM
dti-1327	188	35	.	.	PUNCT
dti-1327	188	36	maldi	maldi	NOUN
dti-1327	188	37	-	-	PUNCT
dti-1327	188	38	tof	tof	PROPN
dti-1327	188	39	mass	mass	ADJ
dti-1327	188	40	spectrometry	spectrometry	NOUN
dti-1327	188	41	analysis	analysis	NOUN
dti-1327	188	42	of	of	ADP
dti-1327	188	43	a	a	PRON
dti-1327	188	44	)	)	PUNCT
dti-1327	188	45	γ-2	γ-2	NOUN
dti-1327	188	46	and	and	CCONJ
dti-1327	188	47	b	b	X
dti-1327	188	48	)	)	PUNCT
dti-1327	188	49	γ-4	γ-4	NOUN
dti-1327	188	50	showing	show	VERB
dti-1327	188	51	a	a	DET
dti-1327	188	52	central	central	ADJ
dti-1327	188	53	peak	peak	NOUN
dti-1327	188	54	at	at	ADP
dti-1327	188	55	ca	ca	NOUN
dti-1327	188	56	.	.	PUNCT
dti-1327	189	1	2400	2400	NUM
dti-1327	189	2	m	m	PROPN
dti-1327	189	3	/	/	SYM
dti-1327	189	4	z	z	PROPN
dti-1327	189	5	and	and	CCONJ
dti-1327	189	6	2846	2846	NUM
dti-1327	189	7	m	m	NOUN
dti-1327	189	8	/	/	SYM
dti-1327	189	9	z	z	NOUN
dti-1327	189	10	respectively	respectively	ADV
dti-1327	189	11	.	.	PUNCT
dti-1327	190	1	icp	icp	PROPN
dti-1327	190	2	also	also	ADV
dti-1327	190	3	confi	confi	VERB
dti-1327	190	4	rmed	rme	VERB
dti-1327	190	5	the	the	DET
dti-1327	190	6	presence	presence	NOUN
dti-1327	190	7	of	of	ADP
dti-1327	190	8	gallium	gallium	NOUN
dti-1327	190	9	in	in	ADP
dti-1327	190	10	γ-4	γ-4	NOUN
dti-1327	190	11	.	.	PUNCT
dti-1327	191	1	21	21	NUM
dti-1327	191	2	targeting	target	VERB
dti-1327	191	3	gallium	gallium	NOUN
dti-1327	191	4	to	to	ADP
dti-1327	191	5	cancer	cancer	NOUN
dti-1327	191	6	cells	cell	NOUN
dti-1327	191	7	through	through	ADP
dti-1327	191	8	the	the	DET
dti-1327	191	9	folate	folate	NOUN
dti-1327	191	10	receptor	receptor	NOUN
dti-1327	191	11	drug	drug	NOUN
dti-1327	191	12	target	target	NOUN
dti-1327	191	13	insights	insight	NOUN
dti-1327	191	14	2008:3	2008:3	NUM
dti-1327	191	15	(	(	PUNCT
dti-1327	191	16	csajbok	csajbok	PROPN
dti-1327	191	17	et	et	PROPN
dti-1327	191	18	al	al	PROPN
dti-1327	191	19	.	.	PROPN
dti-1327	191	20	2004	2004	NUM
dti-1327	191	21	)	)	PUNCT
dti-1327	191	22	.	.	PUNCT
dti-1327	192	1	similarly	similarly	ADV
dti-1327	192	2	,	,	PUNCT
dti-1327	192	3	proton	proton	NOUN
dti-1327	192	4	exchange	exchange	NOUN
dti-1327	192	5	can	can	AUX
dti-1327	192	6	occur	occur	VERB
dti-1327	192	7	between	between	ADP
dti-1327	192	8	ring	re	VERB
dti-1327	192	9	amine	amine	ADJ
dti-1327	192	10	groups	group	NOUN
dti-1327	192	11	and	and	CCONJ
dti-1327	192	12	the	the	DET
dti-1327	192	13	carboxylate	carboxylate	NOUN
dti-1327	192	14	pendant	pendant	ADJ
dti-1327	192	15	arms	arm	NOUN
dti-1327	192	16	,	,	PUNCT
dti-1327	192	17	which	which	PRON
dti-1327	192	18	may	may	AUX
dti-1327	192	19	trigger	trigger	VERB
dti-1327	192	20	decomplexation	decomplexation	NOUN
dti-1327	192	21	(	(	PUNCT
dti-1327	192	22	goddard	goddard	NOUN
dti-1327	192	23	et	et	PROPN
dti-1327	192	24	al	al	PROPN
dti-1327	192	25	.	.	PROPN
dti-1327	192	26	2001	2001	NUM
dti-1327	192	27	)	)	PUNCT
dti-1327	192	28	.	.	PUNCT
dti-1327	193	1	with	with	ADP
dti-1327	193	2	the	the	DET
dti-1327	193	3	ligand	ligand	NOUN
dti-1327	193	4	’s	’s	PART
dti-1327	193	5	dynamic	dynamic	ADJ
dti-1327	193	6	exchange	exchange	NOUN
dti-1327	193	7	process	process	NOUN
dti-1327	193	8	occurring	occur	VERB
dti-1327	193	9	in	in	ADP
dti-1327	193	10	solution	solution	NOUN
dti-1327	193	11	decomplexation	decomplexation	NOUN
dti-1327	193	12	can	can	AUX
dti-1327	193	13	occur	occur	VERB
dti-1327	193	14	.	.	PUNCT
dti-1327	194	1	a	a	DET
dti-1327	194	2	whole	whole	ADJ
dti-1327	194	3	series	series	NOUN
dti-1327	194	4	of	of	ADP
dti-1327	194	5	gallium	gallium	NOUN
dti-1327	194	6	compounds	compound	NOUN
dti-1327	194	7	have	have	AUX
dti-1327	194	8	been	be	AUX
dti-1327	194	9	screened	screen	VERB
dti-1327	194	10	for	for	ADP
dti-1327	194	11	in	in	ADP
dti-1327	194	12	vitro	vitro	X
dti-1327	194	13	cytotoxicity	cytotoxicity	NOUN
dti-1327	194	14	.	.	PUNCT
dti-1327	195	1	a	a	DET
dti-1327	195	2	series	series	NOUN
dti-1327	195	3	of	of	ADP
dti-1327	195	4	gallium	gallium	NOUN
dti-1327	195	5	compounds	compound	VERB
dti-1327	195	6	with	with	ADP
dti-1327	195	7	signifi	signifi	NOUN
dti-1327	195	8	ca	can	AUX
dti-1327	195	9	nt	not	PART
dti-1327	195	10	toxicity	toxicity	NOUN
dti-1327	195	11	are	be	AUX
dti-1327	195	12	shown	show	VERB
dti-1327	195	13	for	for	ADP
dti-1327	195	14	comparision	comparision	NOUN
dti-1327	195	15	in	in	ADP
dti-1327	195	16	table	table	NOUN
dti-1327	195	17	3	3	NUM
dti-1327	195	18	.	.	PUNCT
dti-1327	195	19	to	to	PART
dti-1327	195	20	prove	prove	VERB
dti-1327	195	21	that	that	SCONJ
dti-1327	195	22	gallium	gallium	NOUN
dti-1327	195	23	has	have	AUX
dti-1327	195	24	indeed	indeed	ADV
dti-1327	195	25	been	be	AUX
dti-1327	195	26	“	"	PUNCT
dti-1327	195	27	freed	free	VERB
dti-1327	195	28	”	"	PUNCT
dti-1327	195	29	from	from	ADP
dti-1327	195	30	its	its	PRON
dti-1327	195	31	macrocyclic	macrocyclic	NOUN
dti-1327	195	32	cage	cage	NOUN
dti-1327	195	33	,	,	PUNCT
dti-1327	195	34	stability	stability	NOUN
dti-1327	195	35	studies	study	NOUN
dti-1327	195	36	in	in	ADP
dti-1327	195	37	hepes	hepe	NOUN
dti-1327	195	38	buffer	buffer	NOUN
dti-1327	195	39	and	and	CCONJ
dti-1327	195	40	rpmi	rpmi	VERB
dti-1327	195	41	1640	1640	NUM
dti-1327	195	42	media	medium	NOUN
dti-1327	195	43	over	over	ADP
dti-1327	195	44	72	72	NUM
dti-1327	195	45	hours	hour	NOUN
dti-1327	195	46	coupled	couple	VERB
dti-1327	195	47	with	with	ADP
dti-1327	195	48	hplc	hplc	NOUN
dti-1327	195	49	and	and	CCONJ
dti-1327	195	50	icp	icp	PROPN
dti-1327	195	51	techniques	technique	NOUN
dti-1327	195	52	were	be	AUX
dti-1327	195	53	conducted	conduct	VERB
dti-1327	195	54	.	.	PUNCT
dti-1327	196	1	new	new	ADJ
dti-1327	196	2	peaks	peak	NOUN
dti-1327	196	3	were	be	AUX
dti-1327	196	4	observed	observe	VERB
dti-1327	196	5	between	between	ADP
dti-1327	196	6	48	48	NUM
dti-1327	196	7	and	and	CCONJ
dti-1327	196	8	72	72	NUM
dti-1327	196	9	hours	hour	NOUN
dti-1327	196	10	indicative	indicative	ADJ
dti-1327	196	11	of	of	ADP
dti-1327	196	12	gallium	gallium	NOUN
dti-1327	196	13	release	release	NOUN
dti-1327	196	14	(	(	PUNCT
dti-1327	196	15	see	see	VERB
dti-1327	196	16	supplemental	supplemental	ADJ
dti-1327	196	17	material	material	NOUN
dti-1327	196	18	)	)	PUNCT
dti-1327	196	19	.	.	PUNCT
dti-1327	197	1	these	these	DET
dti-1327	197	2	peaks	peak	NOUN
dti-1327	197	3	were	be	AUX
dti-1327	197	4	analyzed	analyze	VERB
dti-1327	197	5	via	via	ADP
dti-1327	197	6	icp	icp	PROPN
dti-1327	197	7	and	and	CCONJ
dti-1327	197	8	gallium	gallium	NOUN
dti-1327	197	9	was	be	AUX
dti-1327	197	10	noted	note	VERB
dti-1327	197	11	.	.	PUNCT
dti-1327	198	1	in	in	ADP
dti-1327	198	2	addition	addition	NOUN
dti-1327	198	3	,	,	PUNCT
dti-1327	198	4	a	a	DET
dti-1327	198	5	slight	slight	ADJ
dti-1327	198	6	precipitate	precipitate	NOUN
dti-1327	198	7	could	could	AUX
dti-1327	198	8	be	be	AUX
dti-1327	198	9	removed	remove	VERB
dti-1327	198	10	by	by	ADP
dti-1327	198	11	fi	fi	NOUN
dti-1327	198	12	ltration	ltration	NOUN
dti-1327	198	13	(	(	PUNCT
dti-1327	198	14	0.22	0.22	NUM
dti-1327	198	15	µm	µm	ADP
dti-1327	198	16	fi	fi	NOUN
dti-1327	198	17	lters	lter	NOUN
dti-1327	198	18	)	)	PUNCT
dti-1327	198	19	and	and	CCONJ
dti-1327	198	20	icp	icp	PROPN
dti-1327	198	21	confi	confi	PROPN
dti-1327	198	22	rmed	rme	VERB
dti-1327	198	23	the	the	DET
dti-1327	198	24	presence	presence	NOUN
dti-1327	198	25	of	of	ADP
dti-1327	198	26	gallium	gallium	NOUN
dti-1327	198	27	in	in	ADP
dti-1327	198	28	the	the	DET
dti-1327	198	29	collected	collect	VERB
dti-1327	198	30	solid	solid	ADJ
dti-1327	198	31	fraction	fraction	NOUN
dti-1327	198	32	.	.	PUNCT
dti-1327	199	1	attempts	attempt	NOUN
dti-1327	199	2	to	to	PART
dti-1327	199	3	identify	identify	VERB
dti-1327	199	4	the	the	DET
dti-1327	199	5	new	new	ADJ
dti-1327	199	6	species	specie	NOUN
dti-1327	199	7	were	be	AUX
dti-1327	199	8	unsuccessful	unsuccessful	ADJ
dti-1327	199	9	by	by	ADP
dti-1327	199	10	electrospray	electrospray	ADJ
dti-1327	199	11	mass	mass	NOUN
dti-1327	199	12	spectrometry	spectrometry	NOUN
dti-1327	199	13	and	and	CCONJ
dti-1327	199	14	1h	1h	NUM
dti-1327	199	15	nmr	nmr	NOUN
dti-1327	199	16	and	and	CCONJ
dti-1327	199	17	attempts	attempt	NOUN
dti-1327	199	18	to	to	PART
dti-1327	199	19	obtain	obtain	VERB
dti-1327	199	20	crystals	crystal	NOUN
dti-1327	199	21	for	for	ADP
dti-1327	199	22	x	x	NOUN
dti-1327	199	23	-	-	NOUN
dti-1327	199	24	ray	ray	VERB
dti-1327	199	25	structural	structural	ADJ
dti-1327	199	26	analysis	analysis	NOUN
dti-1327	199	27	also	also	ADV
dti-1327	199	28	proved	prove	VERB
dti-1327	199	29	unsuccessful	unsuccessful	ADJ
dti-1327	199	30	.	.	PUNCT
dti-1327	200	1	it	it	PRON
dti-1327	200	2	is	be	AUX
dti-1327	200	3	likely	likely	ADJ
dti-1327	200	4	that	that	SCONJ
dti-1327	200	5	both	both	CCONJ
dti-1327	200	6	soluble	soluble	ADJ
dti-1327	200	7	and	and	CCONJ
dti-1327	200	8	insoluble	insoluble	ADJ
dti-1327	200	9	gallium	gallium	NOUN
dti-1327	200	10	salts	salt	NOUN
dti-1327	200	11	(	(	PUNCT
dti-1327	200	12	such	such	ADJ
dti-1327	200	13	as	as	ADP
dti-1327	200	14	gallium	gallium	NOUN
dti-1327	200	15	hydroxides	hydroxide	NOUN
dti-1327	200	16	)	)	PUNCT
dti-1327	200	17	are	be	AUX
dti-1327	200	18	forming	form	VERB
dti-1327	200	19	and/or	and/or	CCONJ
dti-1327	200	20	gallium	gallium	NOUN
dti-1327	200	21	is	be	AUX
dti-1327	200	22	complexing	complexe	VERB
dti-1327	200	23	with	with	ADP
dti-1327	200	24	compounds	compound	NOUN
dti-1327	200	25	found	find	VERB
dti-1327	200	26	in	in	ADP
dti-1327	200	27	the	the	DET
dti-1327	200	28	rpmi	rpmi	NOUN
dti-1327	200	29	media	medium	NOUN
dti-1327	200	30	.	.	PUNCT
dti-1327	201	1	the	the	DET
dti-1327	201	2	comparable	comparable	ADJ
dti-1327	201	3	observed	observed	ADJ
dti-1327	201	4	cytotoxicities	cytotoxicity	NOUN
dti-1327	201	5	on	on	ADP
dti-1327	201	6	both	both	DET
dti-1327	201	7	cell	cell	NOUN
dti-1327	201	8	lines	line	NOUN
dti-1327	201	9	can	can	AUX
dti-1327	201	10	then	then	ADV
dti-1327	201	11	be	be	AUX
dti-1327	201	12	ascribed	ascribe	VERB
dti-1327	201	13	to	to	ADP
dti-1327	201	14	gallium	gallium	NOUN
dti-1327	201	15	leaching	leach	VERB
dti-1327	201	16	from	from	ADP
dti-1327	201	17	dota	dota	PROPN
dti-1327	201	18	over	over	ADP
dti-1327	201	19	72	72	NUM
dti-1327	201	20	hours	hour	NOUN
dti-1327	201	21	.	.	PUNCT
dti-1327	202	1	table	table	NOUN
dti-1327	202	2	2	2	NUM
dti-1327	202	3	.	.	PUNCT
dti-1327	203	1	ic50	ic50	PROPN
dti-1327	203	2	concentrations	concentration	NOUN
dti-1327	203	3	for	for	ADP
dti-1327	203	4	1	1	NUM
dti-1327	203	5	,	,	PUNCT
dti-1327	203	6	γ-2	γ-2	PROPN
dti-1327	203	7	,	,	PUNCT
dti-1327	203	8	γ-3	γ-3	PROPN
dti-1327	203	9	,	,	PUNCT
dti-1327	203	10	γ-4	γ-4	PROPN
dti-1327	203	11	and	and	CCONJ
dti-1327	203	12	dota	dota	PROPN
dti-1327	203	13	against	against	ADP
dti-1327	203	14	a2780	a2780	NOUN
dti-1327	203	15	/	/	SYM
dti-1327	203	16	ad	ad	NOUN
dti-1327	203	17	ovarian	ovarian	ADJ
dti-1327	203	18	cells	cell	NOUN
dti-1327	203	19	and	and	CCONJ
dti-1327	203	20	chinese	chinese	ADJ
dti-1327	203	21	hamster	hamster	PROPN
dti-1327	203	22	ovary	ovary	NOUN
dti-1327	203	23	(	(	PUNCT
dti-1327	203	24	cho	cho	ADJ
dti-1327	203	25	)	)	PUNCT
dti-1327	203	26	cells	cell	NOUN
dti-1327	203	27	.	.	PUNCT
dti-1327	204	1	(	(	PUNCT
dti-1327	204	2	−	−	NOUN
dti-1327	204	3	)	)	PUNCT
dti-1327	204	4	indicates	indicate	VERB
dti-1327	204	5	no	no	DET
dti-1327	204	6	ic50	ic50	PROPN
dti-1327	204	7	was	be	AUX
dti-1327	204	8	recorded	record	VERB
dti-1327	204	9	.	.	PUNCT
dti-1327	205	1	azt	azt	PROPN
dti-1327	205	2	was	be	AUX
dti-1327	205	3	used	use	VERB
dti-1327	205	4	as	as	ADP
dti-1327	205	5	a	a	DET
dti-1327	205	6	control	control	NOUN
dti-1327	205	7	and	and	CCONJ
dti-1327	205	8	returned	return	VERB
dti-1327	205	9	an	an	DET
dti-1327	205	10	ic50	ic50	PROPN
dti-1327	205	11	concentration	concentration	NOUN
dti-1327	205	12	of	of	ADP
dti-1327	205	13	∼	∼	NOUN
dti-1327	206	1	6–8	6–8	NOUN
dti-1327	206	2	mm	mm	INTJ
dti-1327	206	3	consistent	consistent	ADJ
dti-1327	206	4	with	with	ADP
dti-1327	206	5	literature	literature	NOUN
dti-1327	206	6	values	value	NOUN
dti-1327	206	7	(	(	PUNCT
dti-1327	206	8	doyle	doyle	PROPN
dti-1327	206	9	et	et	PROPN
dti-1327	206	10	al	al	PROPN
dti-1327	206	11	.	.	PROPN
dti-1327	206	12	2008	2008	NUM
dti-1327	206	13	)	)	PUNCT
dti-1327	206	14	.	.	PUNCT
dti-1327	207	1	compound	compound	PROPN
dti-1327	207	2	ic50	ic50	PROPN
dti-1327	207	3	(	(	PUNCT
dti-1327	207	4	mm	mm	PROPN
dti-1327	207	5	)	)	PUNCT
dti-1327	207	6	(	(	PUNCT
dti-1327	207	7	72hrs	72hrs	X
dti-1327	207	8	)	)	PUNCT
dti-1327	207	9	cho	cho	PROPN
dti-1327	207	10	a2780	a2780	PROPN
dti-1327	207	11	/	/	SYM
dti-1327	207	12	ad	ad	NOUN
dti-1327	207	13	1	1	NUM
dti-1327	207	14	1.61	1.61	NUM
dti-1327	207	15	0.77	0.77	NUM
dti-1327	207	16	γ-2	γ-2	NOUN
dti-1327	207	17	(	(	PUNCT
dti-1327	207	18	−	−	NOUN
dti-1327	207	19	)	)	PUNCT
dti-1327	207	20	(	(	PUNCT
dti-1327	207	21	−	−	NOUN
dti-1327	207	22	)	)	PUNCT
dti-1327	207	23	γ-3	γ-3	NOUN
dti-1327	207	24	1.35	1.35	NUM
dti-1327	207	25	0.18	0.18	NUM
dti-1327	207	26	γ-4	γ-4	NOUN
dti-1327	207	27	2.93	2.93	NUM
dti-1327	207	28	1.85	1.85	NUM
dti-1327	207	29	dota	dota	NOUN
dti-1327	207	30	0.80	0.80	NUM
dti-1327	207	31	0.58	0.58	NUM
dti-1327	207	32	table	table	NOUN
dti-1327	207	33	3	3	NUM
dti-1327	207	34	.	.	PUNCT
dti-1327	207	35	ga	ga	PROPN
dti-1327	207	36	compounds	compound	NOUN
dti-1327	207	37	of	of	ADP
dti-1327	207	38	various	various	ADJ
dti-1327	207	39	ligands	ligand	NOUN
dti-1327	207	40	(	(	PUNCT
dti-1327	207	41	l	l	NOUN
dti-1327	207	42	)	)	PUNCT
dti-1327	207	43	tested	test	VERB
dti-1327	207	44	on	on	ADP
dti-1327	207	45	cell	cell	NOUN
dti-1327	207	46	lines	line	NOUN
dti-1327	207	47	showing	show	VERB
dti-1327	207	48	signifi	signifi	NOUN
dti-1327	207	49	ca	can	AUX
dti-1327	207	50	nt	not	PART
dti-1327	207	51	antiproliferative	antiproliferative	ADJ
dti-1327	207	52	activity	activity	NOUN
dti-1327	207	53	.	.	PUNCT
dti-1327	208	1	ic50	ic50	PROPN
dti-1327	208	2	concentrations	concentration	NOUN
dti-1327	208	3	were	be	AUX
dti-1327	208	4	obtained	obtain	VERB
dti-1327	208	5	at	at	ADP
dti-1327	208	6	72	72	NUM
dti-1327	208	7	hours	hour	NOUN
dti-1327	208	8	unless	unless	SCONJ
dti-1327	208	9	otherwise	otherwise	ADV
dti-1327	208	10	noted	note	VERB
dti-1327	208	11	.	.	PUNCT
dti-1327	209	1	pih	pih	PROPN
dti-1327	209	2	is	be	AUX
dti-1327	209	3	pyridoxal	pyridoxal	ADJ
dti-1327	209	4	isonicotinoyl	isonicotinoyl	VERB
dti-1327	209	5	hydrazone	hydrazone	NOUN
dti-1327	209	6	.	.	PUNCT
dti-1327	210	1	ligand	ligand	PROPN
dti-1327	210	2	(	(	PUNCT
dti-1327	210	3	l	l	NOUN
dti-1327	210	4	)	)	PUNCT
dti-1327	210	5	ic50	ic50	PROPN
dti-1327	210	6	cell	cell	NOUN
dti-1327	210	7	line	line	NOUN
dti-1327	210	8	references	reference	VERB
dti-1327	210	9	2	2	NUM
dti-1327	210	10	-	-	PUNCT
dti-1327	210	11	acetylpyridine	acetylpyridine	NOUN
dti-1327	210	12	4n	4n	NOUN
dti-1327	210	13	dimethylthiosemicarbazone	dimethylthiosemicarbazone	NOUN
dti-1327	210	14	1.33	1.33	NUM
dti-1327	210	15	+	+	NOUN
dti-1327	210	16	/−	/−	PROPN
dti-1327	210	17	0.43	0.43	NUM
dti-1327	210	18	nm	nm	NOUN
dti-1327	210	19	–	–	PUNCT
dti-1327	210	20	96	96	NUM
dti-1327	210	21	hr	hr	NOUN
dti-1327	210	22	2.10	2.10	NUM
dti-1327	210	23	+	+	NOUN
dti-1327	210	24	/−	/−	PROPN
dti-1327	210	25	0.90	0.90	NUM
dti-1327	210	26	nm	nm	NOUN
dti-1327	210	27	–	–	PUNCT
dti-1327	210	28	96	96	NUM
dti-1327	210	29	hr	hr	NOUN
dti-1327	210	30	0.18	0.18	NUM
dti-1327	211	1	+	+	NOUN
dti-1327	211	2	/−	/−	PROPN
dti-1327	211	3	0.02	0.02	NUM
dti-1327	211	4	nm	nm	NOUN
dti-1327	211	5	–	–	PUNCT
dti-1327	211	6	96	96	NUM
dti-1327	211	7	hr	hr	NOUN
dti-1327	211	8	ovarian	ovarian	NOUN
dti-1327	211	9	:	:	PUNCT
dti-1327	211	10	41	41	NUM
dti-1327	211	11	m	m	NOUN
dti-1327	211	12	mammary	mammary	ADJ
dti-1327	211	13	:	:	PUNCT
dti-1327	211	14	sk	sk	PROPN
dti-1327	211	15	-	-	PUNCT
dti-1327	211	16	br3	br3	PROPN
dti-1327	211	17	colon	colon	NOUN
dti-1327	211	18	:	:	PUNCT
dti-1327	211	19	sw480	sw480	PROPN
dti-1327	211	20	26	26	NUM
dti-1327	211	21	kenpaullone	kenpaullone	PROPN
dti-1327	211	22	�	�	PROPN
dti-1327	211	23	1	1	NUM
dti-1327	211	24	µm	µm	ADP
dti-1327	211	25	–	–	PUNCT
dti-1327	211	26	48	48	NUM
dti-1327	211	27	hr	hr	NOUN
dti-1327	211	28	lung	lung	NOUN
dti-1327	211	29	:	:	PUNCT
dti-1327	211	30	ccrf	ccrf	NOUN
dti-1327	211	31	-	-	PUNCT
dti-1327	211	32	cem	cem	NOUN
dti-1327	211	33	;	;	PUNCT
dti-1327	211	34	27	27	NUM
dti-1327	211	35	k-562	k-562	NOUN
dti-1327	211	36	;	;	PUNCT
dti-1327	211	37	mlt-4	mlt-4	NUM
dti-1327	211	38	�	�	X
dti-1327	211	39	5	5	NUM
dti-1327	211	40	µm	µm	NOUN
dti-1327	211	41	–	–	PUNCT
dti-1327	211	42	48	48	NUM
dti-1327	211	43	hr	hr	NOUN
dti-1327	211	44	colon	colon	NOUN
dti-1327	211	45	:	:	PUNCT
dti-1327	211	46	hct-116	hct-116	PROPN
dti-1327	211	47	;	;	PUNCT
dti-1327	211	48	hct-15	hct-15	NUM
dti-1327	211	49	;	;	PUNCT
dti-1327	211	50	ht29	ht29	PROPN
dti-1327	211	51	;	;	PUNCT
dti-1327	211	52	sw-620	sw-620	PROPN
dti-1327	211	53	�	�	PROPN
dti-1327	211	54	1	1	NUM
dti-1327	211	55	µm	µm	NOUN
dti-1327	211	56	–	–	PUNCT
dti-1327	211	57	48	48	NUM
dti-1327	211	58	hr	hr	NOUN
dti-1327	211	59	melanoma	melanoma	NOUN
dti-1327	211	60	:	:	PUNCT
dti-1327	211	61	sk	sk	PROPN
dti-1327	211	62	-	-	PUNCT
dti-1327	211	63	mel-28	mel-28	NOUN
dti-1327	211	64	;	;	PUNCT
dti-1327	211	65	sk	sk	PROPN
dti-1327	211	66	-	-	PUNCT
dti-1327	211	67	mel-5	mel-5	NUM
dti-1327	211	68	�	�	PROPN
dti-1327	211	69	10	10	NUM
dti-1327	211	70	µm	µm	NOUN
dti-1327	211	71	–	–	PUNCT
dti-1327	211	72	48	48	NUM
dti-1327	211	73	hr	hr	NOUN
dti-1327	211	74	ovarian	ovarian	NOUN
dti-1327	211	75	:	:	PUNCT
dti-1327	211	76	ovcar-3	ovcar-3	NUM
dti-1327	211	77	�	�	PROPN
dti-1327	211	78	10	10	NUM
dti-1327	211	79	µm	µm	ADP
dti-1327	211	80	-48	-48	PUNCT
dti-1327	211	81	hr	hr	NOUN
dti-1327	211	82	breast	breast	NOUN
dti-1327	211	83	:	:	PUNCT
dti-1327	211	84	mcf7	mcf7	PROPN
dti-1327	211	85	pih	pih	PROPN
dti-1327	211	86	50	50	NUM
dti-1327	211	87	µm	µm	ADP
dti-1327	211	88	lung	lung	NOUN
dti-1327	211	89	:	:	PUNCT
dti-1327	211	90	ccrf	ccrf	NOUN
dti-1327	211	91	-	-	PUNCT
dti-1327	211	92	cem	cem	NOUN
dti-1327	211	93	28	28	NUM
dti-1327	211	94	chloride	chloride	NOUN
dti-1327	211	95	175	175	NUM
dti-1327	211	96	µm	µm	NOUN
dti-1327	211	97	–	–	PUNCT
dti-1327	211	98	48	48	NUM
dti-1327	211	99	hr	hr	NOUN
dti-1327	211	100	leukemia	leukemia	NOUN
dti-1327	211	101	:	:	PUNCT
dti-1327	211	102	l1210	l1210	NOUN
dti-1327	211	103	29	29	NUM
dti-1327	211	104	16	16	NUM
dti-1327	211	105	µm	µm	NOUN
dti-1327	211	106	–	–	PUNCT
dti-1327	211	107	96	96	NUM
dti-1327	211	108	hr	hr	NOUN
dti-1327	211	109	transferrin	transferrin	NOUN
dti-1327	211	110	1.1	1.1	NUM
dti-1327	211	111	+	+	NOUN
dti-1327	211	112	/0.2	/0.2	PROPN
dti-1327	211	113	µm	µm	ADP
dti-1327	211	114	leukemia	leukemia	NOUN
dti-1327	211	115	:	:	PUNCT
dti-1327	212	1	hl60	hl60	PROPN
dti-1327	212	2	30	30	NUM
dti-1327	212	3	nitrate	nitrate	NOUN
dti-1327	212	4	120	120	NUM
dti-1327	212	5	µm	µm	ADP
dti-1327	212	6	lung	lung	NOUN
dti-1327	212	7	:	:	PUNCT
dti-1327	212	8	ccrf	ccrf	NOUN
dti-1327	212	9	-	-	PUNCT
dti-1327	212	10	cem	cem	NOUN
dti-1327	212	11	2	2	NUM
dti-1327	212	12	80	80	NUM
dti-1327	212	13	µm	µm	ADP
dti-1327	212	14	s	s	NOUN
dti-1327	212	15	-	-	PUNCT
dti-1327	212	16	phase	phase	NOUN
dti-1327	212	17	arrest	arrest	NOUN
dti-1327	212	18	lung	lung	NOUN
dti-1327	212	19	1	1	NUM
dti-1327	212	20	1.61	1.61	NUM
dti-1327	212	21	mm	mm	NOUN
dti-1327	212	22	ovarian	ovarian	NOUN
dti-1327	212	23	:	:	PUNCT
dti-1327	212	24	cho	cho	VERB
dti-1327	212	25	this	this	DET
dti-1327	212	26	work	work	NOUN
dti-1327	212	27	0.77	0.77	NUM
dti-1327	212	28	mm	mm	NOUN
dti-1327	212	29	ovarian	ovarian	NOUN
dti-1327	212	30	:	:	PUNCT
dti-1327	212	31	a2789	a2789	NOUN
dti-1327	212	32	/	/	SYM
dti-1327	212	33	ad	ad	NOUN
dti-1327	212	34	γ-3	γ-3	NOUN
dti-1327	212	35	1.35	1.35	NUM
dti-1327	212	36	mm	mm	NOUN
dti-1327	212	37	ovarian	ovarian	NOUN
dti-1327	212	38	:	:	PUNCT
dti-1327	212	39	cho	cho	VERB
dti-1327	212	40	this	this	DET
dti-1327	212	41	work	work	NOUN
dti-1327	212	42	180	180	NUM
dti-1327	212	43	µm	µm	ADP
dti-1327	212	44	ovarian	ovarian	NOUN
dti-1327	212	45	:	:	PUNCT
dti-1327	212	46	a2789	a2789	NOUN
dti-1327	212	47	/	/	SYM
dti-1327	212	48	ad	ad	NOUN
dti-1327	212	49	γ-4	γ-4	NOUN
dti-1327	212	50	2.93	2.93	NUM
dti-1327	212	51	mm	mm	NOUN
dti-1327	212	52	ovarian	ovarian	NOUN
dti-1327	212	53	:	:	PUNCT
dti-1327	212	54	cho	cho	VERB
dti-1327	212	55	this	this	DET
dti-1327	212	56	work	work	NOUN
dti-1327	212	57	1.85	1.85	NUM
dti-1327	212	58	mm	mm	NOUN
dti-1327	212	59	ovarian	ovarian	NOUN
dti-1327	212	60	:	:	PUNCT
dti-1327	212	61	a2789	a2789	NUM
dti-1327	212	62	/	/	SYM
dti-1327	212	63	ad	ad	NOUN
dti-1327	212	64	22	22	NUM
dti-1327	212	65	viola	viola	PROPN
dti-1327	212	66	-	-	PUNCT
dti-1327	212	67	villegas	villegas	PROPN
dti-1327	212	68	et	et	PROPN
dti-1327	212	69	al	al	PROPN
dti-1327	212	70	drug	drug	PROPN
dti-1327	212	71	target	target	NOUN
dti-1327	212	72	insights	insight	NOUN
dti-1327	212	73	2008:3	2008:3	NUM
dti-1327	212	74	conclusion	conclusion	NOUN
dti-1327	212	75	we	we	PRON
dti-1327	212	76	have	have	AUX
dti-1327	212	77	successfully	successfully	ADV
dti-1327	212	78	synthesized	synthesize	VERB
dti-1327	212	79	,	,	PUNCT
dti-1327	212	80	characterized	characterize	VERB
dti-1327	212	81	,	,	PUNCT
dti-1327	212	82	and	and	CCONJ
dti-1327	212	83	investigated	investigate	VERB
dti-1327	212	84	the	the	DET
dti-1327	212	85	in	in	ADV
dti-1327	212	86	vitro	vitro	X
dti-1327	212	87	cytotoxicity	cytotoxicity	NOUN
dti-1327	212	88	studies	study	NOUN
dti-1327	212	89	of	of	ADP
dti-1327	212	90	dota	dota	PROPN
dti-1327	212	91	based	base	VERB
dti-1327	212	92	gallium	gallium	NOUN
dti-1327	212	93	complexes	complex	NOUN
dti-1327	212	94	and	and	CCONJ
dti-1327	212	95	conducted	conduct	VERB
dti-1327	212	96	controls	control	NOUN
dti-1327	212	97	to	to	PART
dti-1327	212	98	track	track	VERB
dti-1327	212	99	the	the	DET
dti-1327	212	100	source	source	NOUN
dti-1327	212	101	of	of	ADP
dti-1327	212	102	the	the	DET
dti-1327	212	103	toxicity	toxicity	NOUN
dti-1327	212	104	.	.	PUNCT
dti-1327	213	1	these	these	DET
dti-1327	213	2	results	result	NOUN
dti-1327	213	3	demonstrate	demonstrate	VERB
dti-1327	213	4	that	that	SCONJ
dti-1327	213	5	while	while	SCONJ
dti-1327	213	6	a	a	DET
dti-1327	213	7	ligand	ligand	NOUN
dti-1327	213	8	of	of	ADP
dti-1327	213	9	extraordinary	extraordinary	ADJ
dti-1327	213	10	kinetic	kinetic	NOUN
dti-1327	213	11	and	and	CCONJ
dti-1327	213	12	thermodynamic	thermodynamic	ADJ
dti-1327	213	13	stability	stability	NOUN
dti-1327	213	14	gallium	gallium	NOUN
dti-1327	213	15	can	can	AUX
dti-1327	213	16	‘	'	PUNCT
dti-1327	213	17	leach	leach	NOUN
dti-1327	213	18	’	'	PUNCT
dti-1327	213	19	from	from	ADP
dti-1327	213	20	dota	dota	PROPN
dti-1327	213	21	over	over	ADP
dti-1327	213	22	a	a	DET
dti-1327	213	23	72	72	NUM
dti-1327	213	24	-	-	PUNCT
dti-1327	213	25	hour	hour	NOUN
dti-1327	213	26	period	period	NOUN
dti-1327	213	27	.	.	PUNCT
dti-1327	214	1	what	what	PRON
dti-1327	214	2	is	be	AUX
dti-1327	214	3	also	also	ADV
dti-1327	214	4	clear	clear	ADJ
dti-1327	214	5	is	be	AUX
dti-1327	214	6	that	that	SCONJ
dti-1327	214	7	dota	dota	PROPN
dti-1327	214	8	itself	itself	PRON
dti-1327	214	9	has	have	VERB
dti-1327	214	10	between	between	ADP
dti-1327	214	11	[	[	X
dti-1327	214	12	500–800	500–800	NUM
dti-1327	214	13	µm	µm	NOUN
dti-1327	214	14	]	]	PUNCT
dti-1327	214	15	toxicity	toxicity	NOUN
dti-1327	214	16	,	,	PUNCT
dti-1327	214	17	an	an	DET
dti-1327	214	18	interesting	interesting	ADJ
dti-1327	214	19	note	note	NOUN
dti-1327	214	20	in	in	ADP
dti-1327	214	21	and	and	CCONJ
dti-1327	214	22	of	of	ADP
dti-1327	214	23	itself	itself	PRON
dti-1327	214	24	.	.	PUNCT
dti-1327	215	1	toxicity	toxicity	NOUN
dti-1327	215	2	in	in	ADP
dti-1327	215	3	both	both	DET
dti-1327	215	4	lines	line	NOUN
dti-1327	215	5	could	could	AUX
dti-1327	215	6	be	be	AUX
dti-1327	215	7	explained	explain	VERB
dti-1327	215	8	by	by	ADP
dti-1327	215	9	the	the	DET
dti-1327	215	10	uptake	uptake	NOUN
dti-1327	215	11	,	,	PUNCT
dti-1327	215	12	by	by	ADP
dti-1327	215	13	diffusion	diffusion	NOUN
dti-1327	215	14	,	,	PUNCT
dti-1327	215	15	of	of	ADP
dti-1327	215	16	free	free	ADJ
dti-1327	215	17	dota	dota	PROPN
dti-1327	215	18	or	or	CCONJ
dti-1327	215	19	gallium	gallium	NOUN
dti-1327	215	20	-	-	PUNCT
dti-1327	215	21	dota	dota	PROPN
dti-1327	215	22	,	,	PUNCT
dti-1327	215	23	or	or	CCONJ
dti-1327	215	24	the	the	DET
dti-1327	215	25	presence	presence	NOUN
dti-1327	215	26	of	of	ADP
dti-1327	215	27	uncomplexed	uncomplexe	VERB
dti-1327	215	28	dota	dota	PROPN
dti-1327	215	29	and/or	and/or	CCONJ
dti-1327	215	30	the	the	DET
dti-1327	215	31	release	release	NOUN
dti-1327	215	32	of	of	ADP
dti-1327	215	33	gallium	gallium	NOUN
dti-1327	215	34	from	from	ADP
dti-1327	215	35	the	the	DET
dti-1327	215	36	conjugate	conjugate	NOUN
dti-1327	215	37	as	as	ADP
dti-1327	215	38	applicable	applicable	ADJ
dti-1327	215	39	in	in	ADP
dti-1327	215	40	the	the	DET
dti-1327	215	41	fa	fa	NOUN
dti-1327	215	42	-	-	PUNCT
dti-1327	215	43	peg	peg	NOUN
dti-1327	215	44	containing	contain	VERB
dti-1327	215	45	systems	system	NOUN
dti-1327	215	46	.	.	PUNCT
dti-1327	216	1	clearly	clearly	ADV
dti-1327	216	2	the	the	DET
dti-1327	216	3	fact	fact	NOUN
dti-1327	216	4	that	that	SCONJ
dti-1327	216	5	free	free	ADJ
dti-1327	216	6	dota	dota	PROPN
dti-1327	216	7	has	have	AUX
dti-1327	216	8	greater	great	ADJ
dti-1327	216	9	toxicity	toxicity	NOUN
dti-1327	216	10	than	than	SCONJ
dti-1327	216	11	the	the	DET
dti-1327	216	12	gallium	gallium	NOUN
dti-1327	216	13	complexed	complexe	VERB
dti-1327	216	14	forms	form	NOUN
dti-1327	216	15	described	describe	VERB
dti-1327	216	16	herein	herein	NOUN
dti-1327	216	17	,	,	PUNCT
dti-1327	216	18	make	make	VERB
dti-1327	216	19	them	they	PRON
dti-1327	216	20	unsuitable	unsuitable	ADJ
dti-1327	216	21	as	as	ADP
dti-1327	216	22	anticancer	anticancer	NOUN
dti-1327	216	23	agents	agent	NOUN
dti-1327	216	24	themselves	themselves	PRON
dti-1327	216	25	.	.	PUNCT
dti-1327	217	1	there	there	PRON
dti-1327	217	2	is	be	VERB
dti-1327	217	3	however	however	ADV
dti-1327	217	4	a	a	DET
dti-1327	217	5	signifi	signifi	NOUN
dti-1327	217	6	ca	can	AUX
dti-1327	217	7	nt	not	PART
dti-1327	217	8	difference	difference	VERB
dti-1327	217	9	on	on	ADP
dti-1327	217	10	fr	fr	NOUN
dti-1327	217	11	containing	contain	VERB
dti-1327	217	12	cells	cell	NOUN
dti-1327	217	13	over	over	ADP
dti-1327	217	14	non	non	ADJ
dti-1327	217	15	-	-	ADJ
dti-1327	217	16	fr	fr	ADJ
dti-1327	217	17	containing	contain	VERB
dti-1327	217	18	cells	cell	NOUN
dti-1327	217	19	in	in	ADP
dti-1327	217	20	terms	term	NOUN
dti-1327	217	21	of	of	ADP
dti-1327	217	22	selectivity	selectivity	NOUN
dti-1327	217	23	,	,	PUNCT
dti-1327	217	24	as	as	ADV
dti-1327	217	25	well	well	ADV
dti-1327	217	26	as	as	ADP
dti-1327	217	27	suffi	suffi	NOUN
dti-1327	217	28	cient	cient	NOUN
dti-1327	217	29	stability	stability	NOUN
dti-1327	217	30	,	,	PUNCT
dti-1327	217	31	to	to	PART
dti-1327	217	32	suggest	suggest	VERB
dti-1327	217	33	that	that	SCONJ
dti-1327	217	34	coupling	couple	VERB
dti-1327	217	35	the	the	DET
dti-1327	217	36	γ	γ	X
dti-1327	217	37	-	-	PUNCT
dti-1327	217	38	emitting	emit	VERB
dti-1327	217	39	67ga	67ga	ADJ
dti-1327	217	40	isotope	isotope	NOUN
dti-1327	217	41	or	or	CCONJ
dti-1327	217	42	the	the	DET
dti-1327	217	43	β	β	NOUN
dti-1327	217	44	-	-	ADJ
dti-1327	217	45	emitting	emit	VERB
dti-1327	217	46	68ga	68ga	ADJ
dti-1327	217	47	isotope	isotope	NOUN
dti-1327	217	48	to	to	ADP
dti-1327	217	49	the	the	DET
dti-1327	217	50	fa	fa	NOUN
dti-1327	217	51	-	-	PUNCT
dti-1327	217	52	peg	peg	NOUN
dti-1327	217	53	conjugate	conjugate	ADJ
dti-1327	217	54	unit	unit	NOUN
dti-1327	217	55	may	may	AUX
dti-1327	217	56	provide	provide	VERB
dti-1327	217	57	a	a	DET
dti-1327	217	58	suitable	suitable	ADJ
dti-1327	217	59	route	route	NOUN
dti-1327	217	60	to	to	ADP
dti-1327	217	61	targeting	target	VERB
dti-1327	217	62	radioisotopes	radioisotope	NOUN
dti-1327	217	63	of	of	ADP
dti-1327	217	64	gallium	gallium	NOUN
dti-1327	217	65	to	to	ADP
dti-1327	217	66	cell	cell	NOUN
dti-1327	217	67	lines	line	NOUN
dti-1327	217	68	for	for	ADP
dti-1327	217	69	use	use	NOUN
dti-1327	217	70	as	as	ADP
dti-1327	217	71	diagnostic	diagnostic	ADJ
dti-1327	217	72	agents	agent	NOUN
dti-1327	217	73	.	.	PUNCT
dti-1327	218	1	this	this	DET
dti-1327	218	2	work	work	NOUN
dti-1327	218	3	is	be	AUX
dti-1327	218	4	currently	currently	ADV
dti-1327	218	5	being	be	AUX
dti-1327	218	6	investigated	investigate	VERB
dti-1327	218	7	in	in	ADP
dti-1327	218	8	the	the	DET
dti-1327	218	9	group	group	NOUN
dti-1327	218	10	.	.	PUNCT
dti-1327	219	1	acknowledgments	acknowledgment	NOUN
dti-1327	219	2	the	the	DET
dti-1327	219	3	authors	author	NOUN
dti-1327	219	4	wish	wish	VERB
dti-1327	219	5	to	to	PART
dti-1327	219	6	thank	thank	VERB
dti-1327	219	7	syracuse	syracuse	PROPN
dti-1327	219	8	university	university	PROPN
dti-1327	219	9	and	and	CCONJ
dti-1327	219	10	the	the	DET
dti-1327	219	11	ilearn	ilearn	ADJ
dti-1327	219	12	program	program	NOUN
dti-1327	219	13	for	for	ADP
dti-1327	219	14	funding	funding	NOUN
dti-1327	219	15	.	.	PUNCT
dti-1327	220	1	we	we	PRON
dti-1327	220	2	also	also	ADV
dti-1327	220	3	thank	thank	VERB
dti-1327	220	4	karen	karen	PROPN
dti-1327	220	5	l.	l.	PROPN
dti-1327	220	6	howard	howard	PROPN
dti-1327	220	7	(	(	PUNCT
dti-1327	220	8	state	state	PROPN
dti-1327	220	9	university	university	PROPN
dti-1327	220	10	of	of	ADP
dti-1327	220	11	new	new	PROPN
dti-1327	220	12	york	york	PROPN
dti-1327	220	13	,	,	PUNCT
dti-1327	220	14	esf	esf	PROPN
dti-1327	220	15	)	)	PUNCT
dti-1327	220	16	and	and	CCONJ
dti-1327	220	17	chris	chris	PROPN
dti-1327	220	18	incarvito	incarvito	PROPN
dti-1327	220	19	(	(	PUNCT
dti-1327	220	20	yale	yale	PROPN
dti-1327	220	21	university	university	PROPN
dti-1327	220	22	)	)	PUNCT
dti-1327	220	23	for	for	ADP
dti-1327	220	24	assistance	assistance	NOUN
dti-1327	220	25	obtaining	obtain	VERB
dti-1327	220	26	maldi	maldi	NOUN
dti-1327	220	27	-	-	PUNCT
dti-1327	220	28	tof	tof	PRON
dti-1327	220	29	mass	mass	NOUN
dti-1327	220	30	spectra	spectra	NOUN
dti-1327	220	31	and	and	CCONJ
dti-1327	220	32	colin	colin	PROPN
dti-1327	220	33	fuss	fuss	PROPN
dti-1327	220	34	(	(	PUNCT
dti-1327	220	35	cese	cese	PROPN
dti-1327	220	36	,	,	PUNCT
dti-1327	220	37	su	su	PROPN
dti-1327	220	38	)	)	PUNCT
dti-1327	220	39	for	for	ADP
dti-1327	220	40	conducting	conduct	VERB
dti-1327	220	41	icp	icp	PROPN
dti-1327	220	42	.	.	PUNCT
dti-1327	221	1	supporting	support	VERB
dti-1327	221	2	material	material	NOUN
dti-1327	221	3	hplc	hplc	NOUN
dti-1327	221	4	stability	stability	NOUN
dti-1327	221	5	traces	trace	NOUN
dti-1327	221	6	and	and	CCONJ
dti-1327	221	7	ic50	ic50	PROPN
dti-1327	221	8	graphs	graph	NOUN
dti-1327	221	9	showing	show	VERB
dti-1327	221	10	exponential	exponential	ADJ
dti-1327	221	11	plots	plot	NOUN
dti-1327	221	12	.	.	PUNCT
dti-1327	222	1	references	reference	NOUN
dti-1327	222	2	anderson	anderson	PROPN
dti-1327	222	3	,	,	PUNCT
dti-1327	222	4	r.g	r.g	PROPN
dti-1327	222	5	.	.	PROPN
dti-1327	222	6	,	,	PUNCT
dti-1327	222	7	kamen	kamen	PROPN
dti-1327	222	8	,	,	PUNCT
dti-1327	222	9	b.a	b.a	PROPN
dti-1327	222	10	.	.	PROPN
dti-1327	222	11	,	,	PUNCT
dti-1327	222	12	wang	wang	PROPN
dti-1327	222	13	,	,	PUNCT
dti-1327	222	14	m.t/	m.t/	PROPN
dti-1327	222	15	et	et	PROPN
dti-1327	222	16	al	al	PROPN
dti-1327	222	17	.	.	PROPN
dti-1327	222	18	1988	1988	NUM
dti-1327	222	19	.	.	PUNCT
dti-1327	223	1	delivery	delivery	NOUN
dti-1327	223	2	of	of	ADP
dti-1327	223	3	folates	folate	NOUN
dti-1327	223	4	to	to	ADP
dti-1327	223	5	the	the	DET
dti-1327	223	6	cytoplasm	cytoplasm	NOUN
dti-1327	223	7	of	of	ADP
dti-1327	223	8	ma104	ma104	NOUN
dti-1327	223	9	cells	cell	NOUN
dti-1327	223	10	is	be	AUX
dti-1327	223	11	mediated	mediate	VERB
dti-1327	223	12	by	by	ADP
dti-1327	223	13	a	a	DET
dti-1327	223	14	surface	surface	NOUN
dti-1327	223	15	membrane	membrane	NOUN
dti-1327	223	16	receptor	receptor	NOUN
dti-1327	223	17	that	that	PRON
dti-1327	223	18	recycles	recycle	VERB
dti-1327	223	19	.	.	PUNCT
dti-1327	224	1	j.	j.	PROPN
dti-1327	224	2	biol	biol	PROPN
dti-1327	224	3	.	.	PUNCT
dti-1327	225	1	chem	chem	PROPN
dti-1327	225	2	.	.	PUNCT
dti-1327	225	3	,	,	PUNCT
dti-1327	226	1	263:13602–9	263:13602–9	NUM
dti-1327	226	2	.	.	PUNCT
dti-1327	226	3	anderson	anderson	PROPN
dti-1327	226	4	,	,	PUNCT
dti-1327	226	5	r.g	r.g	PROPN
dti-1327	226	6	.	.	PROPN
dti-1327	226	7	,	,	PUNCT
dti-1327	226	8	rothberg	rothberg	PROPN
dti-1327	226	9	,	,	PUNCT
dti-1327	226	10	k.g	k.g	PROPN
dti-1327	226	11	.	.	PROPN
dti-1327	226	12	,	,	PUNCT
dti-1327	226	13	ying	ying	PROPN
dti-1327	226	14	,	,	PUNCT
dti-1327	226	15	y.s	y.s	PROPN
dti-1327	226	16	.	.	PROPN
dti-1327	226	17	et	et	PROPN
dti-1327	226	18	al	al	PROPN
dti-1327	226	19	.	.	PROPN
dti-1327	226	20	1990	1990	NUM
dti-1327	226	21	.	.	PUNCT
dti-1327	227	1	the	the	DET
dti-1327	227	2	glycophospholipidlinked	glycophospholipidlinke	VERB
dti-1327	227	3	folate	folate	NOUN
dti-1327	227	4	receptor	receptor	NOUN
dti-1327	227	5	internalizes	internalize	VERB
dti-1327	227	6	folate	folate	NOUN
dti-1327	227	7	without	without	ADP
dti-1327	227	8	entering	enter	VERB
dti-1327	227	9	the	the	DET
dti-1327	227	10	clathrincoated	clathrincoate	VERB
dti-1327	227	11	pit	pit	NOUN
dti-1327	227	12	endocytic	endocytic	ADJ
dti-1327	227	13	pathway	pathway	NOUN
dti-1327	227	14	.	.	PUNCT
dti-1327	228	1	j.	j.	PROPN
dti-1327	228	2	cell	cell	PROPN
dti-1327	228	3	.	.	PUNCT
dti-1327	229	1	biol	biol	PROPN
dti-1327	229	2	.	.	PUNCT
dti-1327	229	3	,	,	PUNCT
dti-1327	229	4	110:637–49	110:637–49	NUM
dti-1327	229	5	.	.	PUNCT
dti-1327	230	1	antony	antony	PROPN
dti-1327	230	2	,	,	PUNCT
dti-1327	230	3	a.c	a.c	PROPN
dti-1327	230	4	.	.	PROPN
dti-1327	230	5	1996	1996	NUM
dti-1327	230	6	.	.	PUNCT
dti-1327	231	1	folate	folate	NOUN
dti-1327	231	2	receptors	receptor	NOUN
dti-1327	231	3	.	.	PUNCT
dti-1327	232	1	annu	annu	NOUN
dti-1327	232	2	.	.	PUNCT
dti-1327	232	3	rev	rev	PROPN
dti-1327	232	4	.	.	PROPN
dti-1327	232	5	nutr	nutr	PROPN
dti-1327	232	6	.	.	PROPN
dti-1327	232	7	,	,	PUNCT
dti-1327	232	8	16:501–21	16:501–21	PROPN
dti-1327	232	9	.	.	PUNCT
dti-1327	233	1	chitambar	chitambar	PROPN
dti-1327	233	2	,	,	PUNCT
dti-1327	233	3	c.r	c.r	PROPN
dti-1327	233	4	.	.	PROPN
dti-1327	233	5	,	,	PUNCT
dti-1327	233	6	matthaeus	matthaeus	PROPN
dti-1327	233	7	,	,	PUNCT
dti-1327	233	8	w.g	w.g	PROPN
dti-1327	233	9	.	.	PROPN
dti-1327	233	10	,	,	PUNCT
dti-1327	233	11	antholine	antholine	PROPN
dti-1327	233	12	,	,	PUNCT
dti-1327	233	13	w.e	w.e	PROPN
dti-1327	233	14	.	.	PROPN
dti-1327	233	15	et	et	PROPN
dti-1327	233	16	al	al	PROPN
dti-1327	233	17	.	.	PROPN
dti-1327	233	18	1988	1988	NUM
dti-1327	233	19	.	.	PUNCT
dti-1327	234	1	inhibition	inhibition	NOUN
dti-1327	234	2	of	of	ADP
dti-1327	234	3	leukemic	leukemic	ADJ
dti-1327	234	4	hl60	hl60	PROPN
dti-1327	234	5	cell	cell	NOUN
dti-1327	234	6	growth	growth	NOUN
dti-1327	234	7	by	by	ADP
dti-1327	234	8	transferrin	transferrin	NOUN
dti-1327	234	9	-	-	PUNCT
dti-1327	234	10	gallium	gallium	NOUN
dti-1327	234	11	:	:	PUNCT
dti-1327	234	12	effects	effect	NOUN
dti-1327	234	13	on	on	ADP
dti-1327	234	14	ribonucleotide	ribonucleotide	ADJ
dti-1327	234	15	reductase	reductase	NOUN
dti-1327	234	16	and	and	CCONJ
dti-1327	234	17	demonstration	demonstration	NOUN
dti-1327	234	18	of	of	ADP
dti-1327	234	19	drug	drug	NOUN
dti-1327	234	20	synergy	synergy	NOUN
dti-1327	234	21	with	with	ADP
dti-1327	234	22	hydroxyurea	hydroxyurea	PROPN
dti-1327	234	23	.	.	PUNCT
dti-1327	235	1	blood	blood	NOUN
dti-1327	235	2	,	,	PUNCT
dti-1327	235	3	72:1930–6	72:1930–6	NUM
dti-1327	235	4	.	.	PUNCT
dti-1327	236	1	clarke	clarke	PROPN
dti-1327	236	2	,	,	PUNCT
dti-1327	236	3	e.t	e.t	PROPN
dti-1327	236	4	.	.	PROPN
dti-1327	236	5	and	and	CCONJ
dti-1327	236	6	martell	martell	PROPN
dti-1327	236	7	,	,	PUNCT
dti-1327	236	8	a.e	a.e	PROPN
dti-1327	236	9	.	.	PROPN
dti-1327	236	10	1991	1991	NUM
dti-1327	236	11	.	.	PUNCT
dti-1327	237	1	stabilities	stability	NOUN
dti-1327	237	2	of	of	ADP
dti-1327	237	3	trivalent	trivalent	ADJ
dti-1327	237	4	metal	metal	NOUN
dti-1327	237	5	ion	ion	NOUN
dti-1327	237	6	complexes	complex	NOUN
dti-1327	237	7	of	of	ADP
dti-1327	237	8	the	the	DET
dti-1327	237	9	tetraacetate	tetraacetate	NOUN
dti-1327	237	10	derivatives	derivative	NOUN
dti-1327	237	11	of	of	ADP
dti-1327	237	12	12-	12-	NUM
dti-1327	237	13	,	,	PUNCT
dti-1327	237	14	13and	13and	NOUN
dti-1327	237	15	14	14	NUM
dti-1327	237	16	-	-	PUNCT
dti-1327	237	17	membered	membere	VERB
dti-1327	237	18	tetraazamacrocycles	tetraazamacrocycle	NOUN
dti-1327	237	19	.	.	PUNCT
dti-1327	238	1	inorg	inorg	PROPN
dti-1327	238	2	.	.	PUNCT
dti-1327	239	1	chimica	chimica	PROPN
dti-1327	239	2	.	.	PUNCT
dti-1327	240	1	acta	acta	PROPN
dti-1327	240	2	.	.	PROPN
dti-1327	240	3	,	,	PUNCT
dti-1327	241	1	190:37–46	190:37–46	X
dti-1327	241	2	.	.	PUNCT
dti-1327	241	3	csajbok	csajbok	PROPN
dti-1327	241	4	,	,	PUNCT
dti-1327	241	5	e.	e.	PROPN
dti-1327	241	6	,	,	PUNCT
dti-1327	241	7	banyai	banyai	PROPN
dti-1327	241	8	,	,	PUNCT
dti-1327	241	9	i.	i.	NOUN
dti-1327	241	10	and	and	CCONJ
dti-1327	241	11	brucher	brucher	PROPN
dti-1327	241	12	,	,	PUNCT
dti-1327	241	13	e.	e.	PROPN
dti-1327	241	14	2004	2004	PROPN
dti-1327	241	15	.	.	PUNCT
dti-1327	242	1	dynamic	dynamic	ADJ
dti-1327	242	2	nmr	nmr	NOUN
dti-1327	242	3	properties	property	NOUN
dti-1327	242	4	of	of	ADP
dti-1327	242	5	dota	dota	PROPN
dti-1327	242	6	ligand	ligand	NOUN
dti-1327	242	7	:	:	PUNCT
dti-1327	242	8	variable	variable	ADJ
dti-1327	242	9	ph	ph	NOUN
dti-1327	242	10	and	and	CCONJ
dti-1327	242	11	temperature	temperature	NOUN
dti-1327	242	12	1h	1h	NUM
dti-1327	242	13	nmr	nmr	NOUN
dti-1327	242	14	study	study	NOUN
dti-1327	242	15	on	on	ADP
dti-1327	242	16	[	[	X
dti-1327	242	17	k(hxdota)](3	k(hxdota)](3	NOUN
dti-1327	242	18	-	-	PUNCT
dti-1327	242	19	x)species	x)species	PROPN
dti-1327	242	20	.	.	PUNCT
dti-1327	243	1	dalton	dalton	PROPN
dti-1327	243	2	trans	trans	PROPN
dti-1327	243	3	.	.	PROPN
dti-1327	243	4	,14:2152–6	,14:2152–6	PROPN
dti-1327	243	5	.	.	PUNCT
dti-1327	244	1	delgado	delgado	PROPN
dti-1327	244	2	,	,	PUNCT
dti-1327	244	3	r.	r.	PROPN
dti-1327	244	4	,	,	PUNCT
dti-1327	244	5	sun	sun	NOUN
dti-1327	244	6	,	,	PUNCT
dti-1327	244	7	y.	y.	PROPN
dti-1327	244	8	,	,	PUNCT
dti-1327	244	9	martell	martell	PROPN
dti-1327	244	10	,	,	PUNCT
dti-1327	244	11	a.e	a.e	PROPN
dti-1327	244	12	.	.	PROPN
dti-1327	244	13	et	et	PROPN
dti-1327	244	14	al	al	PROPN
dti-1327	244	15	.	.	PROPN
dti-1327	244	16	1993	1993	NUM
dti-1327	244	17	.	.	PUNCT
dti-1327	245	1	stabilities	stability	NOUN
dti-1327	245	2	of	of	ADP
dti-1327	245	3	divalent	divalent	NOUN
dti-1327	245	4	and	and	CCONJ
dti-1327	245	5	trivalent	trivalent	NOUN
dti-1327	245	6	metal	metal	NOUN
dti-1327	245	7	ion	ion	NOUN
dti-1327	245	8	complexes	complex	NOUN
dti-1327	245	9	of	of	ADP
dti-1327	245	10	macrocyclic	macrocyclic	ADJ
dti-1327	245	11	triazatriacetic	triazatriacetic	ADJ
dti-1327	245	12	acids	acid	NOUN
dti-1327	245	13	.	.	PUNCT
dti-1327	246	1	inorg	inorg	PROPN
dti-1327	246	2	.	.	PUNCT
dti-1327	247	1	chem	chem	PROPN
dti-1327	247	2	.	.	PUNCT
dti-1327	247	3	,	,	PUNCT
dti-1327	247	4	32:3320–6	32:3320–6	NUM
dti-1327	247	5	.	.	PUNCT
dti-1327	247	6	desoize	desoize	PROPN
dti-1327	247	7	,	,	PUNCT
dti-1327	247	8	b.	b.	PROPN
dti-1327	247	9	2004	2004	NUM
dti-1327	247	10	.	.	PUNCT
dti-1327	248	1	metals	metal	NOUN
dti-1327	248	2	and	and	CCONJ
dti-1327	248	3	metal	metal	NOUN
dti-1327	248	4	compounds	compound	NOUN
dti-1327	248	5	in	in	ADP
dti-1327	248	6	cancer	cancer	NOUN
dti-1327	248	7	treatment	treatment	NOUN
dti-1327	248	8	.	.	PUNCT
dti-1327	249	1	anticancer	anticancer	NOUN
dti-1327	249	2	res	re	NOUN
dti-1327	249	3	.	.	PROPN
dti-1327	249	4	,	,	PUNCT
dti-1327	249	5	24:1529–44	24:1529–44	NUM
dti-1327	249	6	.	.	PUNCT
dti-1327	250	1	doyle	doyle	PROPN
dti-1327	250	2	,	,	PUNCT
dti-1327	250	3	r.p	r.p	PROPN
dti-1327	250	4	.	.	PROPN
dti-1327	250	5	,	,	PUNCT
dti-1327	250	6	viola	viola	PROPN
dti-1327	250	7	,	,	PUNCT
dti-1327	250	8	n.a	n.a	PROPN
dti-1327	250	9	,	,	PUNCT
dti-1327	250	10	ouellette	ouellette	PROPN
dti-1327	250	11	,	,	PUNCT
dti-1327	250	12	w.	w.	PROPN
dti-1327	250	13	et	et	PROPN
dti-1327	250	14	al	al	PROPN
dti-1327	250	15	.	.	PROPN
dti-1327	250	16	2006	2006	NUM
dti-1327	250	17	.	.	PUNCT
dti-1327	251	1	synthesis	synthesis	NOUN
dti-1327	251	2	,	,	PUNCT
dti-1327	251	3	structure	structure	NOUN
dti-1327	251	4	and	and	CCONJ
dti-1327	251	5	thermal	thermal	ADJ
dti-1327	251	6	analysis	analysis	NOUN
dti-1327	251	7	of	of	ADP
dti-1327	251	8	the	the	DET
dti-1327	251	9	gallium	gallium	NOUN
dti-1327	251	10	complex	complex	NOUN
dti-1327	251	11	of	of	ADP
dti-1327	251	12	1,4,7,10	1,4,7,10	NUM
dti-1327	251	13	-	-	PUNCT
dti-1327	251	14	tetraazacyclododecane	tetraazacyclododecane	NOUN
dti-1327	251	15	-	-	PUNCT
dti-1327	251	16	n	n	CCONJ
dti-1327	251	17	,	,	PUNCT
dti-1327	251	18	n’,n’’,n’’’-tetraacetic	n’,n’’,n’’’-tetraacetic	ADJ
dti-1327	251	19	acid	acid	NOUN
dti-1327	251	20	(	(	PUNCT
dti-1327	251	21	dota	dota	PROPN
dti-1327	251	22	)	)	PUNCT
dti-1327	251	23	.	.	PUNCT
dti-1327	252	1	polyhedron	polyhedron	NOUN
dti-1327	252	2	,	,	PUNCT
dti-1327	252	3	25:3457–62	25:3457–62	NUM
dti-1327	252	4	.	.	PUNCT
dti-1327	253	1	doyle	doyle	PROPN
dti-1327	253	2	,	,	PUNCT
dti-1327	253	3	r.p	r.p	PROPN
dti-1327	253	4	.	.	PROPN
dti-1327	253	5	,	,	PUNCT
dti-1327	253	6	vortherms	vortherm	NOUN
dti-1327	253	7	,	,	PUNCT
dti-1327	253	8	a.r	a.r	PROPN
dti-1327	253	9	.	.	PROPN
dti-1327	253	10	,	,	PUNCT
dti-1327	253	11	sinko	sinko	PROPN
dti-1327	253	12	,	,	PUNCT
dti-1327	253	13	d.g	d.g	PROPN
dti-1327	253	14	.	.	PROPN
dti-1327	253	15	et	et	PROPN
dti-1327	253	16	al	al	PROPN
dti-1327	253	17	.	.	PROPN
dti-1327	253	18	2008	2008	NUM
dti-1327	253	19	.	.	PUNCT
dti-1327	254	1	synthesis	synthesis	NOUN
dti-1327	254	2	,	,	PUNCT
dti-1327	254	3	characterization	characterization	NOUN
dti-1327	254	4	and	and	CCONJ
dti-1327	254	5	in	in	ADP
dti-1327	254	6	vitro	vitro	X
dti-1327	254	7	assay	assay	NOUN
dti-1327	254	8	of	of	ADP
dti-1327	254	9	folic	folic	ADJ
dti-1327	254	10	acid	acid	NOUN
dti-1327	254	11	conjugates	conjugate	NOUN
dti-1327	254	12	of	of	ADP
dti-1327	254	13	3′(-azido3′(-deoxythymidine	3′(-azido3′(-deoxythymidine	NUM
dti-1327	254	14	(	(	PUNCT
dti-1327	254	15	azt	azt	PROPN
dti-1327	254	16	):	):	PUNCT
dti-1327	254	17	towards	towards	ADP
dti-1327	254	18	targeted	target	VERB
dti-1327	254	19	azt	azt	PROPN
dti-1327	254	20	based	base	VERB
dti-1327	254	21	anti	anti	ADJ
dti-1327	254	22	-	-	ADJ
dti-1327	254	23	cancer	cancer	ADJ
dti-1327	254	24	therapeutics	therapeutic	NOUN
dti-1327	254	25	.	.	PUNCT
dti-1327	255	1	nucleosides	nucleoside	NOUN
dti-1327	255	2	,	,	PUNCT
dti-1327	255	3	nucleotides	nucleotide	NOUN
dti-1327	255	4	and	and	CCONJ
dti-1327	255	5	nucleic	nucleic	ADJ
dti-1327	255	6	acids	acid	NOUN
dti-1327	255	7	,	,	PUNCT
dti-1327	255	8	27:173–85	27:173–85	NUM
dti-1327	255	9	.	.	PUNCT
dti-1327	256	1	gogvadze	gogvadze	NOUN
dti-1327	256	2	,	,	PUNCT
dti-1327	256	3	v.	v.	CCONJ
dti-1327	256	4	,	,	PUNCT
dti-1327	256	5	khassanova	khassanova	PROPN
dti-1327	256	6	,	,	PUNCT
dti-1327	256	7	z.	z.	PROPN
dti-1327	256	8	,	,	PUNCT
dti-1327	256	9	collery	collery	NOUN
dti-1327	256	10	,	,	PUNCT
dti-1327	256	11	p.	p.	NOUN
dti-1327	256	12	et	et	NOUN
dti-1327	257	1	al	al	PROPN
dti-1327	257	2	.	.	PROPN
dti-1327	257	3	1996	1996	NUM
dti-1327	257	4	.	.	PUNCT
dti-1327	258	1	the	the	DET
dti-1327	258	2	effect	effect	NOUN
dti-1327	258	3	of	of	ADP
dti-1327	258	4	gallium	gallium	NOUN
dti-1327	258	5	on	on	ADP
dti-1327	258	6	the	the	DET
dti-1327	258	7	calcium	calcium	NOUN
dti-1327	258	8	retention	retention	NOUN
dti-1327	258	9	capacity	capacity	NOUN
dti-1327	258	10	of	of	ADP
dti-1327	258	11	rat	rat	NOUN
dti-1327	258	12	liver	liver	NOUN
dti-1327	258	13	mitochondria	mitochondria	NOUN
dti-1327	258	14	.	.	PUNCT
dti-1327	259	1	in	in	ADP
dti-1327	259	2	:	:	PUNCT
dti-1327	259	3	collery	collery	NOUN
dti-1327	259	4	,	,	PUNCT
dti-1327	259	5	p.	p.	NOUN
dti-1327	259	6	,	,	PUNCT
dti-1327	259	7	ed	ed	NOUN
dti-1327	259	8	.	.	PROPN
dti-1327	259	9	,	,	PUNCT
dti-1327	259	10	metal	metal	NOUN
dti-1327	259	11	ions	ion	NOUN
dti-1327	259	12	in	in	ADP
dti-1327	259	13	biology	biology	NOUN
dti-1327	259	14	and	and	CCONJ
dti-1327	259	15	medicine	medicine	NOUN
dti-1327	259	16	,	,	PUNCT
dti-1327	259	17	proceedings	proceeding	NOUN
dti-1327	259	18	of	of	ADP
dti-1327	259	19	the	the	DET
dti-1327	259	20	international	international	ADJ
dti-1327	259	21	symposium	symposium	NOUN
dti-1327	259	22	on	on	ADP
dti-1327	259	23	metal	metal	NOUN
dti-1327	259	24	ions	ion	NOUN
dti-1327	259	25	in	in	ADP
dti-1327	259	26	biology	biology	NOUN
dti-1327	259	27	and	and	CCONJ
dti-1327	259	28	medicine	medicine	NOUN
dti-1327	259	29	,	,	PUNCT
dti-1327	259	30	4th	4th	ADJ
dti-1327	259	31	,	,	PUNCT
dti-1327	259	32	barcelona	barcelona	PROPN
dti-1327	259	33	.	.	PUNCT
dti-1327	260	1	p.	p.	NOUN
dti-1327	260	2	249–52	249–52	NUM
dti-1327	260	3	.	.	PUNCT
dti-1327	261	1	greenwood	greenwood	PROPN
dti-1327	261	2	,	,	PUNCT
dti-1327	261	3	n.n	n.n	PROPN
dti-1327	261	4	.	.	PROPN
dti-1327	261	5	,	,	PUNCT
dti-1327	261	6	earnshaw	earnshaw	PROPN
dti-1327	261	7	,	,	PUNCT
dti-1327	261	8	a.	a.	NOUN
dti-1327	261	9	1997	1997	NUM
dti-1327	261	10	.	.	PUNCT
dti-1327	262	1	aluminum	aluminum	NOUN
dti-1327	262	2	,	,	PUNCT
dti-1327	262	3	gallium	gallium	NOUN
dti-1327	262	4	,	,	PUNCT
dti-1327	262	5	indium	indium	NOUN
dti-1327	262	6	and	and	CCONJ
dti-1327	262	7	thallium	thallium	NOUN
dti-1327	262	8	.	.	PUNCT
dti-1327	263	1	chemistry	chemistry	NOUN
dti-1327	263	2	of	of	ADP
dti-1327	263	3	the	the	DET
dti-1327	263	4	elements	element	NOUN
dti-1327	263	5	2nd	2nd	PROPN
dti-1327	263	6	ed	ed	NOUN
dti-1327	263	7	.	.	PUNCT
dti-1327	264	1	elsevier	elsevier	PROPN
dti-1327	264	2	science	science	PROPN
dti-1327	264	3	ltd	ltd	PROPN
dti-1327	264	4	.	.	PROPN
dti-1327	264	5	,	,	PUNCT
dti-1327	264	6	burlington	burlington	PROPN
dti-1327	264	7	,	,	PUNCT
dti-1327	264	8	ma	ma	PROPN
dti-1327	264	9	:	:	PUNCT
dti-1327	264	10	publisher	publisher	NOUN
dti-1327	264	11	.	.	PUNCT
dti-1327	265	1	p.	p.	NOUN
dti-1327	265	2	216–67	216–67	NUM
dti-1327	265	3	.	.	PUNCT
dti-1327	266	1	hancock	hancock	PROPN
dti-1327	266	2	,	,	PUNCT
dti-1327	266	3	r.d	r.d	PROPN
dti-1327	266	4	.	.	PROPN
dti-1327	266	5	,	,	PUNCT
dti-1327	266	6	martell	martell	PROPN
dti-1327	266	7	,	,	PUNCT
dti-1327	266	8	a.e	a.e	PROPN
dti-1327	266	9	.	.	PROPN
dti-1327	266	10	1995	1995	NUM
dti-1327	266	11	.	.	PUNCT
dti-1327	267	1	lewis	lewis	PROPN
dti-1327	267	2	acid	acid	NOUN
dti-1327	267	3	-	-	PUNCT
dti-1327	267	4	base	base	NOUN
dti-1327	267	5	behavior	behavior	NOUN
dti-1327	267	6	in	in	ADP
dti-1327	267	7	aqueous	aqueous	ADJ
dti-1327	267	8	solution	solution	NOUN
dti-1327	267	9	:	:	PUNCT
dti-1327	267	10	some	some	DET
dti-1327	267	11	implications	implication	NOUN
dti-1327	267	12	for	for	ADP
dti-1327	267	13	metal	metal	NOUN
dti-1327	267	14	ions	ion	NOUN
dti-1327	267	15	in	in	ADP
dti-1327	267	16	biology	biology	NOUN
dti-1327	267	17	.	.	PUNCT
dti-1327	268	1	adv	adv	PROPN
dti-1327	268	2	.	.	PUNCT
dti-1327	268	3	inorg	inorg	PROPN
dti-1327	268	4	.	.	PUNCT
dti-1327	269	1	chem	chem	PROPN
dti-1327	269	2	.	.	PUNCT
dti-1327	269	3	,	,	PUNCT
dti-1327	270	1	42:89–146	42:89–146	NUM
dti-1327	270	2	.	.	PUNCT
dti-1327	271	1	harpstrite	harpstrite	PROPN
dti-1327	271	2	,	,	PUNCT
dti-1327	271	3	s.e	s.e	PROPN
dti-1327	271	4	.	.	PROPN
dti-1327	271	5	,	,	PUNCT
dti-1327	271	6	prior	prior	ADV
dti-1327	271	7	,	,	PUNCT
dti-1327	271	8	j.l	j.l	PROPN
dti-1327	271	9	.	.	PROPN
dti-1327	271	10	,	,	PUNCT
dti-1327	271	11	sharma	sharma	PROPN
dti-1327	271	12	,	,	PUNCT
dti-1327	271	13	v.	v.	ADP
dti-1327	271	14	et	et	PROPN
dti-1327	271	15	al	al	PROPN
dti-1327	271	16	.	.	PROPN
dti-1327	271	17	2007	2007	NUM
dti-1327	271	18	.	.	PUNCT
dti-1327	272	1	metalloprobes	metalloprobe	NOUN
dti-1327	272	2	:	:	PUNCT
dti-1327	272	3	synthesis	synthesis	NOUN
dti-1327	272	4	,	,	PUNCT
dti-1327	272	5	characterization	characterization	NOUN
dti-1327	272	6	,	,	PUNCT
dti-1327	272	7	and	and	CCONJ
dti-1327	272	8	potency	potency	NOUN
dti-1327	272	9	of	of	ADP
dti-1327	272	10	a	a	DET
dti-1327	272	11	novel	novel	ADJ
dti-1327	272	12	gallium(iii	gallium(iii	NOUN
dti-1327	272	13	)	)	PUNCT
dti-1327	272	14	complex	complex	NOUN
dti-1327	272	15	in	in	ADP
dti-1327	272	16	human	human	ADJ
dti-1327	272	17	epidermal	epidermal	ADJ
dti-1327	272	18	carcinoma	carcinoma	NOUN
dti-1327	272	19	cells	cell	NOUN
dti-1327	272	20	.	.	PUNCT
dti-1327	273	1	j.	j.	PROPN
dti-1327	273	2	inorg	inorg	PROPN
dti-1327	273	3	.	.	PUNCT
dti-1327	274	1	biochem	biochem	PROPN
dti-1327	274	2	.	.	PUNCT
dti-1327	274	3	,	,	PUNCT
dti-1327	274	4	101:1347–53	101:1347–53	PROPN
dti-1327	274	5	.	.	PUNCT
dti-1327	275	1	harris	harris	PROPN
dti-1327	275	2	,	,	PUNCT
dti-1327	275	3	w.r	w.r	PROPN
dti-1327	275	4	.	.	PROPN
dti-1327	275	5	,	,	PUNCT
dti-1327	275	6	martell	martell	PROPN
dti-1327	275	7	,	,	PUNCT
dti-1327	275	8	a.e	a.e	PROPN
dti-1327	275	9	.	.	PROPN
dti-1327	275	10	1976	1976	NUM
dti-1327	275	11	.	.	PUNCT
dti-1327	276	1	aqueous	aqueous	ADJ
dti-1327	276	2	complexes	complex	NOUN
dti-1327	276	3	of	of	ADP
dti-1327	276	4	gallium(iii	gallium(iii	NOUN
dti-1327	276	5	)	)	PUNCT
dti-1327	276	6	.	.	PUNCT
dti-1327	277	1	inorg	inorg	PROPN
dti-1327	277	2	.	.	PUNCT
dti-1327	278	1	chem	chem	PROPN
dti-1327	278	2	.	.	PUNCT
dti-1327	278	3	,	,	PUNCT
dti-1327	278	4	15:713–20	15:713–20	NUM
dti-1327	278	5	.	.	PUNCT
dti-1327	279	1	hart	hart	PROPN
dti-1327	279	2	,	,	PUNCT
dti-1327	279	3	m.m	m.m	PROPN
dti-1327	279	4	.	.	PROPN
dti-1327	279	5	,	,	PUNCT
dti-1327	279	6	yancey	yancey	PROPN
dti-1327	279	7	,	,	PUNCT
dti-1327	279	8	s.t	s.t	PROPN
dti-1327	279	9	.	.	PROPN
dti-1327	279	10	,	,	PUNCT
dti-1327	279	11	adamson	adamson	PROPN
dti-1327	279	12	,	,	PUNCT
dti-1327	279	13	r.h	r.h	PROPN
dti-1327	279	14	.	.	PROPN
dti-1327	279	15	et	et	PROPN
dti-1327	279	16	al	al	PROPN
dti-1327	279	17	.	.	PROPN
dti-1327	279	18	1971	1971	NUM
dti-1327	279	19	.	.	PUNCT
dti-1327	280	1	toxicity	toxicity	NOUN
dti-1327	280	2	and	and	CCONJ
dti-1327	280	3	antitumor	antitumor	PROPN
dti-1327	280	4	activity	activity	NOUN
dti-1327	280	5	of	of	ADP
dti-1327	280	6	gallium	gallium	NOUN
dti-1327	280	7	nitrate	nitrate	NOUN
dti-1327	280	8	and	and	CCONJ
dti-1327	280	9	periodically	periodically	ADV
dti-1327	280	10	related	relate	VERB
dti-1327	280	11	metal	metal	NOUN
dti-1327	280	12	salts	salt	NOUN
dti-1327	280	13	.	.	PUNCT
dti-1327	281	1	j.	j.	PROPN
dti-1327	281	2	natl	natl	PROPN
dti-1327	281	3	.	.	PUNCT
dti-1327	281	4	cancer	cancer	NOUN
dti-1327	281	5	inst	inst	PROPN
dti-1327	281	6	.	.	PROPN
dti-1327	281	7	,	,	PUNCT
dti-1327	281	8	47:1121–7	47:1121–7	X
dti-1327	281	9	.	.	PUNCT
dti-1327	282	1	hedley	hedley	PROPN
dti-1327	282	2	,	,	PUNCT
dti-1327	282	3	d.w	d.w	PROPN
dti-1327	282	4	.	.	PROPN
dti-1327	282	5	,	,	PUNCT
dti-1327	282	6	tripp	tripp	PROPN
dti-1327	282	7	,	,	PUNCT
dti-1327	282	8	e.h	e.h	PROPN
dti-1327	282	9	.	.	PROPN
dti-1327	282	10	,	,	PUNCT
dti-1327	282	11	mann	mann	PROPN
dti-1327	282	12	,	,	PUNCT
dti-1327	282	13	g.j	g.j	PROPN
dti-1327	282	14	.	.	PROPN
dti-1327	282	15	et	et	PROPN
dti-1327	282	16	al	al	PROPN
dti-1327	282	17	.	.	PROPN
dti-1327	282	18	1988	1988	NUM
dti-1327	282	19	.	.	PUNCT
dti-1327	283	1	effect	effect	NOUN
dti-1327	283	2	of	of	ADP
dti-1327	283	3	gallium	gallium	NOUN
dti-1327	283	4	on	on	ADP
dti-1327	283	5	dna	dna	PROPN
dti-1327	283	6	synthesis	synthesis	NOUN
dti-1327	283	7	by	by	ADP
dti-1327	283	8	human	human	PROPN
dti-1327	283	9	t	t	PROPN
dti-1327	283	10	-	-	PUNCT
dti-1327	283	11	cell	cell	NOUN
dti-1327	283	12	lymphoblasts	lymphoblast	NOUN
dti-1327	283	13	.	.	PUNCT
dti-1327	284	1	cancer	cancer	NOUN
dti-1327	284	2	res	re	NOUN
dti-1327	284	3	.	.	PROPN
dti-1327	284	4	,	,	PUNCT
dti-1327	284	5	48:3014–18	48:3014–18	X
dti-1327	284	6	.	.	PUNCT
dti-1327	285	1	jakupec	jakupec	PROPN
dti-1327	285	2	,	,	PUNCT
dti-1327	285	3	m.	m.	NOUN
dti-1327	285	4	,	,	PUNCT
dti-1327	285	5	keppler	keppler	PROPN
dti-1327	285	6	,	,	PUNCT
dti-1327	285	7	b.	b.	PROPN
dti-1327	285	8	2004	2004	NUM
dti-1327	285	9	.	.	PUNCT
dti-1327	286	1	gallium	gallium	NOUN
dti-1327	286	2	and	and	CCONJ
dti-1327	286	3	other	other	ADJ
dti-1327	286	4	main	main	ADJ
dti-1327	286	5	group	group	NOUN
dti-1327	286	6	metal	metal	NOUN
dti-1327	286	7	compounds	compound	NOUN
dti-1327	286	8	as	as	ADP
dti-1327	286	9	antitumor	antitumor	PROPN
dti-1327	286	10	agents	agent	NOUN
dti-1327	286	11	.	.	PUNCT
dti-1327	287	1	in	in	ADP
dti-1327	287	2	siegel	siegel	PROPN
dti-1327	287	3	,	,	PUNCT
dti-1327	287	4	a.	a.	NOUN
dti-1327	287	5	and	and	CCONJ
dti-1327	287	6	siegel	siegel	PROPN
dti-1327	287	7	,	,	PUNCT
dti-1327	287	8	j.	j.	PROPN
dti-1327	287	9	,	,	PUNCT
dti-1327	287	10	eds	eds	PROPN
dti-1327	287	11	.	.	PUNCT
dti-1327	287	12	metal	metal	NOUN
dti-1327	287	13	ions	ion	NOUN
dti-1327	287	14	in	in	ADP
dti-1327	287	15	biological	biological	ADJ
dti-1327	287	16	systems	system	NOUN
dti-1327	287	17	,	,	PUNCT
dti-1327	287	18	vol	vol	NOUN
dti-1327	287	19	.	.	PROPN
dti-1327	288	1	42	42	NUM
dti-1327	288	2	.	.	PUNCT
dti-1327	289	1	dekker	dekker	PROPN
dti-1327	289	2	,	,	PUNCT
dti-1327	289	3	new	new	PROPN
dti-1327	289	4	york	york	PROPN
dti-1327	289	5	:	:	PUNCT
dti-1327	289	6	publisher	publisher	NOUN
dti-1327	289	7	.	.	PUNCT
dti-1327	290	1	p.	p.	NOUN
dti-1327	290	2	425–62	425–62	NUM
dti-1327	290	3	.	.	PUNCT
dti-1327	291	1	keire	keire	PROPN
dti-1327	291	2	,	,	PUNCT
dti-1327	291	3	d.a	d.a	PROPN
dti-1327	291	4	.	.	PROPN
dti-1327	291	5	,	,	PUNCT
dti-1327	291	6	jang	jang	PROPN
dti-1327	291	7	,	,	PUNCT
dti-1327	291	8	y.h	y.h	PROPN
dti-1327	291	9	.	.	PROPN
dti-1327	291	10	,	,	PUNCT
dti-1327	291	11	shively	shively	ADV
dti-1327	291	12	,	,	PUNCT
dti-1327	291	13	j.e	j.e	PROPN
dti-1327	291	14	.	.	PROPN
dti-1327	291	15	et	et	PROPN
dti-1327	291	16	al	al	PROPN
dti-1327	291	17	.	.	PROPN
dti-1327	291	18	2001	2001	NUM
dti-1327	291	19	.	.	PUNCT
dti-1327	292	1	chelators	chelator	NOUN
dti-1327	292	2	for	for	ADP
dti-1327	292	3	radioimmunotherapy	radioimmunotherapy	NOUN
dti-1327	292	4	:	:	PUNCT
dti-1327	292	5	i.	i.	NOUN
dti-1327	292	6	nmr	nmr	PROPN
dti-1327	292	7	and	and	CCONJ
dti-1327	292	8	ab	ab	PROPN
dti-1327	292	9	initio	initio	NOUN
dti-1327	292	10	calculation	calculation	NOUN
dti-1327	292	11	studies	study	NOUN
dti-1327	292	12	on	on	ADP
dti-1327	292	13	1,4,7,10	1,4,7,10	NUM
dti-1327	292	14	-	-	PUNCT
dti-1327	292	15	tetra(carboxyethyl)-1,4,7,10	tetra(carboxyethyl)-1,4,7,10	NOUN
dti-1327	292	16	-	-	PUNCT
dti-1327	292	17	tetraazacyclododecane	tetraazacyclododecane	ADJ
dti-1327	292	18	(	(	PUNCT
dti-1327	292	19	do4pr	do4pr	NOUN
dti-1327	292	20	)	)	PUNCT
dti-1327	292	21	and	and	CCONJ
dti-1327	292	22	1,4,7	1,4,7	NUM
dti-1327	292	23	-	-	PUNCT
dti-1327	292	24	tris(carboxymethyl)-10-(carboxyethyl)-1,4,7,10tetraazacyclododecane	tris(carboxymethyl)-10-(carboxyethyl)-1,4,7,10tetraazacyclododecane	NOUN
dti-1327	292	25	(	(	PUNCT
dti-1327	292	26	do3a1pr	do3a1pr	NOUN
dti-1327	292	27	)	)	PUNCT
dti-1327	292	28	.	.	PUNCT
dti-1327	293	1	inorg	inorg	PROPN
dti-1327	293	2	.	.	PUNCT
dti-1327	294	1	chem	chem	PROPN
dti-1327	294	2	.	.	PUNCT
dti-1327	294	3	,	,	PUNCT
dti-1327	294	4	40:4310–18	40:4310–18	NUM
dti-1327	294	5	.	.	PUNCT
dti-1327	295	1	liu	liu	PROPN
dti-1327	295	2	,	,	PUNCT
dti-1327	295	3	m.	m.	NOUN
dti-1327	295	4	,	,	PUNCT
dti-1327	295	5	xu	xu	PROPN
dti-1327	295	6	,	,	PUNCT
dti-1327	295	7	w.	w.	PROPN
dti-1327	295	8	,	,	PUNCT
dti-1327	295	9	ling	ling	PROPN
dti-1327	295	10	-	-	PUNCT
dti-1327	295	11	jie	jie	PROPN
dti-1327	295	12	,	,	PUNCT
dti-1327	295	13	x.	x.	PROPN
dti-1327	295	14	,	,	PUNCT
dti-1327	295	15	gao	gao	PROPN
dti-1327	295	16	-	-	PUNCT
dti-1327	295	17	ren	ren	PROPN
dti-1327	295	18	,	,	PUNCT
dti-1327	295	19	z.	z.	PROPN
dti-1327	295	20	et	et	PROPN
dti-1327	295	21	al	al	PROPN
dti-1327	295	22	.	.	PROPN
dti-1327	295	23	2005	2005	NUM
dti-1327	295	24	.	.	PUNCT
dti-1327	296	1	synthesis	synthesis	NOUN
dti-1327	296	2	and	and	CCONJ
dti-1327	296	3	biological	biological	ADJ
dti-1327	296	4	evaluation	evaluation	NOUN
dti-1327	296	5	of	of	ADP
dti-1327	296	6	diethylenetriamine	diethylenetriamine	NOUN
dti-1327	296	7	pentaacetic	pentaacetic	ADJ
dti-1327	296	8	acidpolyethylene	acidpolyethylene	NOUN
dti-1327	296	9	glycol	glycol	NOUN
dti-1327	296	10	-	-	PUNCT
dti-1327	296	11	folate	folate	NOUN
dti-1327	296	12	:	:	PUNCT
dti-1327	296	13	a	a	DET
dti-1327	296	14	new	new	ADJ
dti-1327	296	15	folate	folate	NOUN
dti-1327	296	16	-	-	PUNCT
dti-1327	296	17	derived	derive	VERB
dti-1327	296	18	,	,	PUNCT
dti-1327	296	19	99mtc	99mtc	NOUN
dti-1327	296	20	-	-	PUNCT
dti-1327	296	21	based	base	VERB
dti-1327	296	22	radiopharmaceutical	radiopharmaceutical	NOUN
dti-1327	296	23	.	.	PUNCT
dti-1327	297	1	j.	j.	PROPN
dti-1327	297	2	am	am	PROPN
dti-1327	297	3	.	.	PUNCT
dti-1327	298	1	chem	chem	PROPN
dti-1327	298	2	.	.	PUNCT
dti-1327	298	3	,	,	PUNCT
dti-1327	298	4	soc	soc	PROPN
dti-1327	298	5	.	.	PUNCT
dti-1327	298	6	,	,	PUNCT
dti-1327	299	1	6–8	6–8	X
dti-1327	299	2	.	.	PUNCT
dti-1327	299	3	low	low	PROPN
dti-1327	299	4	,	,	PUNCT
dti-1327	299	5	p.s	p.s	PROPN
dti-1327	299	6	.	.	PROPN
dti-1327	299	7	,	,	PUNCT
dti-1327	299	8	lee	lee	PROPN
dti-1327	299	9	,	,	PUNCT
dti-1327	299	10	r.j	r.j	PROPN
dti-1327	299	11	.	.	PROPN
dti-1327	299	12	1994	1994	NUM
dti-1327	299	13	.	.	PUNCT
dti-1327	300	1	delivery	delivery	NOUN
dti-1327	300	2	of	of	ADP
dti-1327	300	3	liposomes	liposome	NOUN
dti-1327	300	4	into	into	ADP
dti-1327	300	5	cultured	cultured	ADJ
dti-1327	300	6	kb	kb	PROPN
dti-1327	300	7	.	.	PUNCT
dti-1327	301	1	cells	cell	NOUN
dti-1327	301	2	via	via	ADP
dti-1327	301	3	folate	folate	NOUN
dti-1327	301	4	receptor	receptor	NOUN
dti-1327	301	5	-	-	PUNCT
dti-1327	301	6	mediated	mediate	VERB
dti-1327	301	7	endocytosis	endocytosis	NOUN
dti-1327	301	8	.	.	PUNCT
dti-1327	302	1	j.	j.	PROPN
dti-1327	302	2	biol	biol	PROPN
dti-1327	302	3	.	.	PUNCT
dti-1327	303	1	chem	chem	PROPN
dti-1327	303	2	.	.	PUNCT
dti-1327	303	3	,	,	PUNCT
dti-1327	303	4	269:3198–204	269:3198–204	PROPN
dti-1327	303	5	.	.	PUNCT
dti-1327	304	1	low	low	ADJ
dti-1327	304	2	,	,	PUNCT
dti-1327	304	3	p.s	p.s	PROPN
dti-1327	304	4	.	.	PROPN
dti-1327	304	5	,	,	PUNCT
dti-1327	304	6	mathias	mathias	PROPN
dti-1327	304	7	,	,	PUNCT
dti-1327	304	8	c.j	c.j	PROPN
dti-1327	304	9	.	.	PROPN
dti-1327	304	10	,	,	PUNCT
dti-1327	304	11	green	green	PROPN
dti-1327	304	12	,	,	PUNCT
dti-1327	304	13	m.a	m.a	PROPN
dti-1327	304	14	.	.	PROPN
dti-1327	304	15	et	et	PROPN
dti-1327	304	16	al	al	PROPN
dti-1327	304	17	.	.	PROPN
dti-1327	304	18	1996	1996	NUM
dti-1327	304	19	.	.	PUNCT
dti-1327	305	1	tumor	tumor	NOUN
dti-1327	305	2	-	-	PUNCT
dti-1327	305	3	selective	selective	ADJ
dti-1327	305	4	radiopharmaceutical	radiopharmaceutical	ADJ
dti-1327	305	5	targeting	targeting	NOUN
dti-1327	305	6	via	via	ADP
dti-1327	305	7	receptor	receptor	NOUN
dti-1327	305	8	-	-	PUNCT
dti-1327	305	9	mediated	mediate	VERB
dti-1327	305	10	endocytosis	endocytosis	NOUN
dti-1327	305	11	of	of	ADP
dti-1327	305	12	gallium-67	gallium-67	PROPN
dti-1327	305	13	-	-	PUNCT
dti-1327	305	14	deferoxamine	deferoxamine	NOUN
dti-1327	305	15	-	-	PUNCT
dti-1327	305	16	folate	folate	NOUN
dti-1327	305	17	.	.	PUNCT
dti-1327	306	1	j.	j.	PROPN
dti-1327	306	2	nucl	nucl	PROPN
dti-1327	306	3	.	.	PUNCT
dti-1327	307	1	med	med	PROPN
dti-1327	307	2	.	.	PROPN
dti-1327	307	3	,	,	PUNCT
dti-1327	307	4	37:1003–8	37:1003–8	X
dti-1327	307	5	.	.	PUNCT
dti-1327	308	1	low	low	ADJ
dti-1327	308	2	,	,	PUNCT
dti-1327	308	3	p.s	p.s	PROPN
dti-1327	308	4	.	.	PROPN
dti-1327	308	5	,	,	PUNCT
dti-1327	308	6	leamon	leamon	PROPN
dti-1327	308	7	,	,	PUNCT
dti-1327	308	8	c.p	c.p	PROPN
dti-1327	308	9	.	.	PROPN
dti-1327	308	10	2005	2005	NUM
dti-1327	308	11	.	.	PUNCT
dti-1327	309	1	receptor	receptor	NOUN
dti-1327	309	2	mediated	mediate	VERB
dti-1327	309	3	drug	drug	NOUN
dti-1327	309	4	delivery	delivery	NOUN
dti-1327	309	5	.	.	PUNCT
dti-1327	310	1	in	in	ADP
dti-1327	310	2	wang	wang	PROPN
dti-1327	310	3	,	,	PUNCT
dti-1327	310	4	b.	b.	PROPN
dti-1327	310	5	,	,	PUNCT
dti-1327	310	6	siahaan	siahaan	PROPN
dti-1327	310	7	,	,	PUNCT
dti-1327	310	8	t.	t.	PROPN
dti-1327	310	9	,	,	PUNCT
dti-1327	310	10	soltero	soltero	PROPN
dti-1327	310	11	,	,	PUNCT
dti-1327	310	12	r.a	r.a	PROPN
dti-1327	310	13	.	.	PROPN
dti-1327	310	14	,	,	PUNCT
dti-1327	310	15	eds	eds	PROPN
dti-1327	310	16	.	.	PUNCT
dti-1327	310	17	drug	drug	NOUN
dti-1327	310	18	delivery	delivery	NOUN
dti-1327	310	19	:	:	PUNCT
dti-1327	310	20	principles	principle	NOUN
dti-1327	310	21	and	and	CCONJ
dti-1327	310	22	applications	application	NOUN
dti-1327	310	23	.	.	PUNCT
dti-1327	311	1	john	john	PROPN
dti-1327	311	2	wiley	wiley	PROPN
dti-1327	311	3	and	and	CCONJ
dti-1327	311	4	sons	sons	PROPN
dti-1327	311	5	inc	inc	PROPN
dti-1327	311	6	.	.	PROPN
dti-1327	311	7	,	,	PUNCT
dti-1327	311	8	new	new	PROPN
dti-1327	311	9	jersey	jersey	PROPN
dti-1327	311	10	:	:	PUNCT
dti-1327	311	11	publisher	publisher	NOUN
dti-1327	311	12	.	.	PUNCT
dti-1327	312	1	p.	p.	NOUN
dti-1327	312	2	167–88	167–88	NUM
dti-1327	312	3	.	.	PUNCT
dti-1327	313	1	qiu	qiu	PROPN
dti-1327	313	2	,	,	PUNCT
dti-1327	313	3	l.y	l.y	PROPN
dti-1327	313	4	.	.	PROPN
dti-1327	313	5	,	,	PUNCT
dti-1327	313	6	bae	bae	PROPN
dti-1327	313	7	,	,	PUNCT
dti-1327	313	8	y.h	y.h	PROPN
dti-1327	313	9	.	.	PROPN
dti-1327	313	10	2006	2006	NUM
dti-1327	313	11	.	.	PUNCT
dti-1327	314	1	polymer	polymer	NOUN
dti-1327	314	2	architecture	architecture	NOUN
dti-1327	314	3	and	and	CCONJ
dti-1327	314	4	drug	drug	NOUN
dti-1327	314	5	delivery	delivery	NOUN
dti-1327	314	6	.	.	PUNCT
dti-1327	315	1	pharm	pharm	NOUN
dti-1327	315	2	.	.	PUNCT
dti-1327	316	1	res	re	NOUN
dti-1327	316	2	.	.	PROPN
dti-1327	316	3	,	,	PUNCT
dti-1327	316	4	23:1–30	23:1–30	NUM
dti-1327	316	5	.	.	PUNCT
dti-1327	317	1	23	23	NUM
dti-1327	317	2	targeting	target	VERB
dti-1327	317	3	gallium	gallium	NOUN
dti-1327	317	4	to	to	ADP
dti-1327	317	5	cancer	cancer	NOUN
dti-1327	317	6	cells	cell	NOUN
dti-1327	317	7	through	through	ADP
dti-1327	317	8	the	the	DET
dti-1327	317	9	folate	folate	NOUN
dti-1327	317	10	receptor	receptor	NOUN
dti-1327	317	11	drug	drug	NOUN
dti-1327	317	12	target	target	NOUN
dti-1327	317	13	insights	insight	NOUN
dti-1327	317	14	2008:3	2008:3	NUM
dti-1327	317	15	ries	rie	NOUN
dti-1327	317	16	,	,	PUNCT
dti-1327	317	17	l.	l.	PROPN
dti-1327	317	18	a.	a.	PROPN
dti-1327	317	19	1993	1993	NUM
dti-1327	317	20	.	.	PUNCT
dti-1327	318	1	ovarian	ovarian	ADJ
dti-1327	318	2	cancer	cancer	NOUN
dti-1327	318	3	.	.	PUNCT
dti-1327	319	1	survival	survival	NOUN
dti-1327	319	2	and	and	CCONJ
dti-1327	319	3	treatment	treatment	NOUN
dti-1327	319	4	differences	difference	NOUN
dti-1327	319	5	by	by	ADP
dti-1327	319	6	age	age	NOUN
dti-1327	319	7	.	.	PUNCT
dti-1327	320	1	cancer	cancer	NOUN
dti-1327	320	2	,	,	PUNCT
dti-1327	320	3	71:524–9	71:524–9	X
dti-1327	320	4	.	.	PUNCT
dti-1327	321	1	rudnev	rudnev	PROPN
dti-1327	321	2	,	,	PUNCT
dti-1327	321	3	a.v	a.v	PROPN
dti-1327	321	4	.	.	PROPN
dti-1327	321	5	,	,	PUNCT
dti-1327	321	6	foteeva	foteeva	PROPN
dti-1327	321	7	,	,	PUNCT
dti-1327	321	8	l.s	l.s	PROPN
dti-1327	321	9	.	.	PROPN
dti-1327	321	10	,	,	PUNCT
dti-1327	321	11	keppler	keppler	PROPN
dti-1327	321	12	,	,	PUNCT
dti-1327	321	13	b.k	b.k	PROPN
dti-1327	321	14	.	.	PROPN
dti-1327	321	15	et	et	PROPN
dti-1327	321	16	al	al	PROPN
dti-1327	321	17	.	.	PROPN
dti-1327	321	18	2006	2006	NUM
dti-1327	321	19	.	.	PUNCT
dti-1327	322	1	preclinical	preclinical	ADJ
dti-1327	322	2	characterization	characterization	NOUN
dti-1327	322	3	of	of	ADP
dti-1327	322	4	anticancer	anticancer	NOUN
dti-1327	322	5	gallium(iii	gallium(iii	NOUN
dti-1327	322	6	)	)	PUNCT
dti-1327	322	7	complexes	complex	NOUN
dti-1327	322	8	:	:	PUNCT
dti-1327	323	1	solubility	solubility	NOUN
dti-1327	323	2	,	,	PUNCT
dti-1327	323	3	stability	stability	NOUN
dti-1327	323	4	,	,	PUNCT
dti-1327	323	5	lipophilicity	lipophilicity	NOUN
dti-1327	323	6	and	and	CCONJ
dti-1327	323	7	binding	bind	VERB
dti-1327	323	8	to	to	ADP
dti-1327	323	9	serum	serum	NOUN
dti-1327	323	10	proteins	protein	NOUN
dti-1327	323	11	.	.	PUNCT
dti-1327	324	1	j.	j.	PROPN
dti-1327	324	2	inorg	inorg	PROPN
dti-1327	324	3	.	.	PUNCT
dti-1327	325	1	biochem	biochem	PROPN
dti-1327	325	2	.	.	PUNCT
dti-1327	325	3	,	,	PUNCT
dti-1327	326	1	100:1819–26	100:1819–26	NUM
dti-1327	326	2	.	.	PUNCT
dti-1327	327	1	shen	shen	PROPN
dti-1327	327	2	,	,	PUNCT
dti-1327	327	3	f.	f.	PROPN
dti-1327	327	4	,	,	PUNCT
dti-1327	327	5	wu	wu	PROPN
dti-1327	327	6	,	,	PUNCT
dti-1327	327	7	m.d	m.d	PROPN
dti-1327	327	8	.	.	PROPN
dti-1327	327	9	,	,	PUNCT
dti-1327	327	10	ratnam	ratnam	PROPN
dti-1327	327	11	,	,	PUNCT
dti-1327	327	12	m.	m.	NOUN
dti-1327	327	13	et	et	PROPN
dti-1327	327	14	al	al	PROPN
dti-1327	327	15	.	.	PROPN
dti-1327	327	16	1995	1995	NUM
dti-1327	327	17	.	.	PUNCT
dti-1327	328	1	folate	folate	NOUN
dti-1327	328	2	receptor	receptor	NOUN
dti-1327	328	3	type	type	NOUN
dti-1327	328	4	gamma	gamma	NOUN
dti-1327	328	5	is	be	AUX
dti-1327	328	6	primarily	primarily	ADV
dti-1327	328	7	a	a	DET
dti-1327	328	8	secretory	secretory	ADJ
dti-1327	328	9	protein	protein	NOUN
dti-1327	328	10	due	due	ADP
dti-1327	328	11	to	to	ADP
dti-1327	328	12	lack	lack	NOUN
dti-1327	328	13	of	of	ADP
dti-1327	328	14	an	an	DET
dti-1327	328	15	effi	effi	PROPN
dti-1327	328	16	cient	cient	NOUN
dti-1327	328	17	signal	signal	NOUN
dti-1327	328	18	for	for	ADP
dti-1327	328	19	glycosylphosphatidylinositol	glycosylphosphatidylinositol	PROPN
dti-1327	328	20	modifi	modifi	NOUN
dti-1327	328	21	cation	cation	NOUN
dti-1327	328	22	:	:	PUNCT
dti-1327	328	23	protein	protein	NOUN
dti-1327	328	24	characterization	characterization	NOUN
dti-1327	328	25	and	and	CCONJ
dti-1327	328	26	cell	cell	NOUN
dti-1327	328	27	type	type	NOUN
dti-1327	328	28	specifi	specifi	PROPN
dti-1327	328	29	city	city	PROPN
dti-1327	328	30	.	.	PUNCT
dti-1327	329	1	biochem	biochem	PROPN
dti-1327	329	2	.	.	PUNCT
dti-1327	329	3	,	,	PUNCT
dti-1327	329	4	34:5660–5	34:5660–5	NUM
dti-1327	329	5	.	.	PUNCT
dti-1327	330	1	sherry	sherry	PROPN
dti-1327	330	2	,	,	PUNCT
dti-1327	330	3	a.d	a.d	PROPN
dti-1327	330	4	.	.	PROPN
dti-1327	330	5	,	,	PUNCT
dti-1327	330	6	brown	brown	PROPN
dti-1327	330	7	,	,	PUNCT
dti-1327	330	8	r.d	r.d	PROPN
dti-1327	330	9	.	.	PROPN
dti-1327	330	10	,	,	PUNCT
dti-1327	330	11	spiller	spiller	NOUN
dti-1327	330	12	,	,	PUNCT
dti-1327	330	13	m.	m.	NOUN
dti-1327	330	14	et	et	PROPN
dti-1327	330	15	al	al	PROPN
dti-1327	330	16	.	.	PROPN
dti-1327	330	17	1989	1989	NUM
dti-1327	330	18	.	.	PUNCT
dti-1327	331	1	synthesis	synthesis	NOUN
dti-1327	331	2	and	and	CCONJ
dti-1327	331	3	characterization	characterization	NOUN
dti-1327	331	4	of	of	ADP
dti-1327	331	5	the	the	DET
dti-1327	331	6	gadolinium(3	gadolinium(3	NOUN
dti-1327	331	7	+	+	NOUN
dti-1327	331	8	)	)	PUNCT
dti-1327	331	9	complex	complex	NOUN
dti-1327	331	10	of	of	ADP
dti-1327	331	11	dota	dota	PROPN
dti-1327	331	12	-	-	PUNCT
dti-1327	331	13	propylamide	propylamide	NOUN
dti-1327	331	14	:	:	PUNCT
dti-1327	331	15	a	a	DET
dti-1327	331	16	model	model	NOUN
dti-1327	331	17	dota	dota	NOUN
dti-1327	331	18	-	-	PUNCT
dti-1327	331	19	protein	protein	NOUN
dti-1327	331	20	conjugate	conjugate	NOUN
dti-1327	331	21	.	.	PUNCT
dti-1327	332	1	inorg	inorg	PROPN
dti-1327	332	2	.	.	PUNCT
dti-1327	333	1	chem	chem	PROPN
dti-1327	333	2	.	.	PUNCT
dti-1327	333	3	,	,	PUNCT
dti-1327	333	4	28:620–22	28:620–22	PROPN
dti-1327	333	5	.	.	PUNCT
dti-1327	334	1	sherry	sherry	PROPN
dti-1327	334	2	,	,	PUNCT
dti-1327	334	3	a.d	a.d	PROPN
dti-1327	334	4	.	.	PROPN
dti-1327	334	5	,	,	PUNCT
dti-1327	334	6	woods	wood	NOUN
dti-1327	334	7	,	,	PUNCT
dti-1327	334	8	m.	m.	NOUN
dti-1327	334	9	,	,	PUNCT
dti-1327	334	10	kovacs	kovacs	PROPN
dti-1327	334	11	,	,	PUNCT
dti-1327	334	12	z.	z.	PROPN
dti-1327	334	13	et	et	PROPN
dti-1327	334	14	al	al	PROPN
dti-1327	334	15	.	.	PROPN
dti-1327	334	16	2004	2004	NUM
dti-1327	334	17	.	.	PUNCT
dti-1327	335	1	solution	solution	NOUN
dti-1327	335	2	dynamics	dynamic	NOUN
dti-1327	335	3	and	and	CCONJ
dti-1327	335	4	stability	stability	NOUN
dti-1327	335	5	of	of	ADP
dti-1327	335	6	lanthanide(iii	lanthanide(iii	NOUN
dti-1327	335	7	)	)	PUNCT
dti-1327	335	8	(	(	PUNCT
dti-1327	335	9	s)-2-(p	s)-2-(p	NOUN
dti-1327	335	10	-	-	PUNCT
dti-1327	335	11	nitrobenzyl)dota	nitrobenzyl)dota	NUM
dti-1327	335	12	complexes	complex	NOUN
dti-1327	335	13	.	.	PUNCT
dti-1327	336	1	inorg	inorg	PROPN
dti-1327	336	2	.	.	PUNCT
dti-1327	337	1	chem	chem	PROPN
dti-1327	337	2	.	.	PUNCT
dti-1327	337	3	,	,	PUNCT
dti-1327	337	4	43:2845–51	43:2845–51	NUM
dti-1327	337	5	.	.	PUNCT
dti-1327	338	1	sun	sun	PROPN
dti-1327	338	2	,	,	PUNCT
dti-1327	338	3	c.c	c.c	PROPN
dti-1327	338	4	.	.	PROPN
dti-1327	338	5	,	,	PUNCT
dti-1327	338	6	bodurka	bodurka	PROPN
dti-1327	338	7	,	,	PUNCT
dti-1327	338	8	d.c	d.c	PROPN
dti-1327	338	9	.	.	PROPN
dti-1327	338	10	,	,	PUNCT
dti-1327	338	11	gershenson	gershenson	PROPN
dti-1327	338	12	,	,	PUNCT
dti-1327	338	13	d.m	d.m	PROPN
dti-1327	338	14	.	.	PROPN
dti-1327	338	15	et	et	PROPN
dti-1327	338	16	al	al	PROPN
dti-1327	338	17	.	.	PROPN
dti-1327	338	18	2002	2002	NUM
dti-1327	338	19	.	.	PUNCT
dti-1327	339	1	patient	patient	ADJ
dti-1327	339	2	preferences	preference	NOUN
dti-1327	339	3	regarding	regard	VERB
dti-1327	339	4	side	side	NOUN
dti-1327	339	5	effects	effect	NOUN
dti-1327	339	6	of	of	ADP
dti-1327	339	7	chemotherapy	chemotherapy	NOUN
dti-1327	339	8	for	for	ADP
dti-1327	339	9	ovarian	ovarian	ADJ
dti-1327	339	10	cancer	cancer	NOUN
dti-1327	339	11	:	:	PUNCT
dti-1327	339	12	do	do	AUX
dti-1327	339	13	they	they	PRON
dti-1327	339	14	change	change	VERB
dti-1327	339	15	over	over	ADP
dti-1327	339	16	time	time	NOUN
dti-1327	339	17	?	?	PUNCT
dti-1327	340	1	gynecologic	gynecologic	ADJ
dti-1327	340	2	oncology	oncology	NOUN
dti-1327	340	3	,	,	PUNCT
dti-1327	340	4	87:118–28	87:118–28	NOUN
dti-1327	340	5	.	.	PUNCT
dti-1327	341	1	veronese	veronese	PROPN
dti-1327	341	2	,	,	PUNCT
dti-1327	341	3	f.m	f.m	PROPN
dti-1327	341	4	.	.	PROPN
dti-1327	341	5	,	,	PUNCT
dti-1327	341	6	schiavon	schiavon	PROPN
dti-1327	341	7	,	,	PUNCT
dti-1327	341	8	o.	o.	PROPN
dti-1327	341	9	,	,	PUNCT
dti-1327	341	10	duncan	duncan	PROPN
dti-1327	341	11	,	,	PUNCT
dti-1327	341	12	r.	r.	PROPN
dti-1327	341	13	et	et	PROPN
dti-1327	341	14	al	al	PROPN
dti-1327	341	15	.	.	PROPN
dti-1327	341	16	2005	2005	NUM
dti-1327	341	17	.	.	PUNCT
dti-1327	342	1	peg	peg	NOUN
dti-1327	342	2	-	-	PUNCT
dti-1327	342	3	doxorubicin	doxorubicin	NOUN
dti-1327	342	4	conjugates	conjugate	NOUN
dti-1327	342	5	:	:	PUNCT
dti-1327	342	6	infl	infl	PROPN
dti-1327	342	7	uence	uence	NOUN
dti-1327	342	8	of	of	ADP
dti-1327	342	9	polymer	polymer	NOUN
dti-1327	342	10	structure	structure	NOUN
dti-1327	342	11	on	on	ADP
dti-1327	342	12	drug	drug	NOUN
dti-1327	342	13	release	release	NOUN
dti-1327	342	14	,	,	PUNCT
dti-1327	342	15	in	in	ADP
dti-1327	342	16	vitro	vitro	X
dti-1327	342	17	cytotoxicity	cytotoxicity	NOUN
dti-1327	342	18	,	,	PUNCT
dti-1327	342	19	biodistribution	biodistribution	NOUN
dti-1327	342	20	,	,	PUNCT
dti-1327	342	21	and	and	CCONJ
dti-1327	342	22	antitumor	antitumor	PROPN
dti-1327	342	23	activity	activity	NOUN
dti-1327	342	24	.	.	PUNCT
dti-1327	343	1	bioconj	bioconj	PROPN
dti-1327	343	2	.	.	PUNCT
dti-1327	344	1	chem	chem	NOUN
dti-1327	344	2	.	.	PUNCT
dti-1327	344	3	,	,	PUNCT
dti-1327	344	4	16:775–84	16:775–84	PROPN
dti-1327	344	5	.	.	PUNCT
dti-1327	345	1	yan	yan	PROPN
dti-1327	345	2	,	,	PUNCT
dti-1327	345	3	w.	w.	PROPN
dti-1327	345	4	,	,	PUNCT
dti-1327	345	5	ratnam	ratnam	PROPN
dti-1327	345	6	,	,	PUNCT
dti-1327	345	7	m.	m.	NOUN
dti-1327	345	8	1995	1995	NUM
dti-1327	345	9	.	.	PUNCT
dti-1327	346	1	preferred	preferred	ADJ
dti-1327	346	2	sites	site	NOUN
dti-1327	346	3	of	of	ADP
dti-1327	346	4	glycosylphosphatidylinositol	glycosylphosphatidylinositol	PROPN
dti-1327	346	5	modifi	modifi	NOUN
dti-1327	346	6	cation	cation	NOUN
dti-1327	346	7	in	in	ADP
dti-1327	346	8	folate	folate	NOUN
dti-1327	346	9	receptors	receptor	NOUN
dti-1327	346	10	and	and	CCONJ
dti-1327	346	11	constraints	constraint	NOUN
dti-1327	346	12	in	in	ADP
dti-1327	346	13	the	the	DET
dti-1327	346	14	primary	primary	ADJ
dti-1327	346	15	structure	structure	NOUN
dti-1327	346	16	of	of	ADP
dti-1327	346	17	the	the	DET
dti-1327	346	18	hydrophobic	hydrophobic	NOUN
dti-1327	346	19	portion	portion	NOUN
dti-1327	346	20	of	of	ADP
dti-1327	346	21	the	the	DET
dti-1327	346	22	signal	signal	NOUN
dti-1327	346	23	.	.	PUNCT
dti-1327	347	1	biochem	biochem	PROPN
dti-1327	347	2	.	.	PUNCT
dti-1327	347	3	,	,	PUNCT
dti-1327	348	1	34:14594–600	34:14594–600	PROPN
dti-1327	348	2	.	.	NOUN
dti-1327	348	3	24	24	NUM
dti-1327	348	4	viola	viola	PROPN
dti-1327	348	5	-	-	PUNCT
dti-1327	348	6	villegas	villegas	PROPN
dti-1327	348	7	et	et	PROPN
dti-1327	348	8	al	al	PROPN
dti-1327	348	9	drug	drug	PROPN
dti-1327	348	10	target	target	NOUN
dti-1327	348	11	insights	insight	NOUN
dti-1327	348	12	2008:3	2008:3	NUM
dti-1327	348	13	targeting	target	VERB
dti-1327	348	14	gallium	gallium	NOUN
dti-1327	348	15	to	to	ADP
dti-1327	348	16	cancer	cancer	NOUN
dti-1327	348	17	cells	cell	NOUN
dti-1327	348	18	through	through	ADP
dti-1327	348	19	the	the	DET
dti-1327	348	20	folate	folate	NOUN
dti-1327	348	21	receptor	receptor	NOUN
dti-1327	348	22	nerissa	nerissa	PROPN
dti-1327	348	23	viola	viola	PROPN
dti-1327	348	24	-	-	PUNCT
dti-1327	348	25	villegas	villegas	PROPN
dti-1327	348	26	,	,	PUNCT
dti-1327	348	27	anthony	anthony	PROPN
dti-1327	348	28	vortherms	vortherm	NOUN
dti-1327	348	29	and	and	CCONJ
dti-1327	348	30	robert	robert	PROPN
dti-1327	348	31	p.	p.	PROPN
dti-1327	348	32	doyle	doyle	PROPN
dti-1327	348	33	department	department	PROPN
dti-1327	348	34	of	of	ADP
dti-1327	348	35	chemistry	chemistry	PROPN
dti-1327	348	36	,	,	PUNCT
dti-1327	348	37	syracuse	syracuse	PROPN
dti-1327	348	38	university	university	PROPN
dti-1327	348	39	,	,	PUNCT
dti-1327	348	40	syracuse	syracuse	PROPN
dti-1327	348	41	,	,	PUNCT
dti-1327	348	42	ny	ny	PROPN
dti-1327	348	43	13244	13244	NUM
dti-1327	348	44	-	-	SYM
dti-1327	348	45	4100	4100	NUM
dti-1327	348	46	,	,	PUNCT
dti-1327	348	47	u.s.a	u.s.a	PROPN
dti-1327	348	48	.	.	PROPN
dti-1327	348	49	supplementary	supplementary	PROPN
dti-1327	348	50	data	datum	NOUN
dti-1327	348	51	(	(	PUNCT
dti-1327	348	52	a	a	NOUN
dti-1327	348	53	)	)	PUNCT
dti-1327	348	54	(	(	PUNCT
dti-1327	348	55	b	b	X
dti-1327	348	56	)	)	PUNCT
dti-1327	348	57	(	(	PUNCT
dti-1327	348	58	c	c	X
dti-1327	348	59	)	)	PUNCT
dti-1327	348	60	(	(	PUNCT
dti-1327	348	61	d	d	X
dti-1327	348	62	)	)	PUNCT
dti-1327	348	63	figure	figure	NOUN
dti-1327	348	64	s1	s1	NOUN
dti-1327	348	65	.	.	PUNCT
dti-1327	349	1	hplc	hplc	NOUN
dti-1327	349	2	traces	trace	NOUN
dti-1327	349	3	of	of	ADP
dti-1327	349	4	γ-4	γ-4	NOUN
dti-1327	349	5	displaying	display	VERB
dti-1327	349	6	peaks	peak	NOUN
dti-1327	349	7	after	after	ADP
dti-1327	349	8	incubation	incubation	NOUN
dti-1327	349	9	at	at	ADP
dti-1327	349	10	37	37	NUM
dti-1327	349	11	°	°	NOUN
dti-1327	349	12	c	c	NOUN
dti-1327	349	13	in	in	ADP
dti-1327	349	14	25	25	NUM
dti-1327	349	15	mm	mm	PROPN
dti-1327	349	16	hepes	hepe	NOUN
dti-1327	349	17	buffer	buffer	NOUN
dti-1327	349	18	(	(	PUNCT
dti-1327	349	19	ph	ph	NOUN
dti-1327	349	20	7.4	7.4	NUM
dti-1327	349	21	)	)	PUNCT
dti-1327	349	22	at	at	ADP
dti-1327	349	23	a	a	PRON
dti-1327	349	24	)	)	PUNCT
dti-1327	349	25	0	0	NUM
dti-1327	349	26	hr	hr	PROPN
dti-1327	349	27	b	b	PROPN
dti-1327	349	28	)	)	PUNCT
dti-1327	349	29	24	24	NUM
dti-1327	349	30	hrs	hrs	NOUN
dti-1327	349	31	c	c	NOUN
dti-1327	349	32	)	)	PUNCT
dti-1327	349	33	48	48	NUM
dti-1327	349	34	hrs	hrs	NOUN
dti-1327	349	35	d	d	NOUN
dti-1327	349	36	)	)	PUNCT
dti-1327	349	37	72	72	NUM
dti-1327	349	38	hrs	hrs	NOUN
dti-1327	349	39	.	.	PUNCT
dti-1327	350	1	icp	icp	PROPN
dti-1327	350	2	confi	confi	PROPN
dti-1327	350	3	rmed	rme	VERB
dti-1327	350	4	presence	presence	NOUN
dti-1327	350	5	of	of	ADP
dti-1327	350	6	gallium	gallium	NOUN
dti-1327	350	7	at	at	ADP
dti-1327	350	8	the	the	DET
dti-1327	350	9	new	new	ADJ
dti-1327	350	10	peaks	peak	NOUN
dti-1327	350	11	growing	grow	VERB
dti-1327	350	12	after	after	ADP
dti-1327	350	13	72	72	NUM
dti-1327	350	14	hrs	hrs	NOUN
dti-1327	350	15	at	at	ADP
dti-1327	350	16	a	a	DET
dti-1327	350	17	retention	retention	NOUN
dti-1327	350	18	time	time	NOUN
dti-1327	350	19	of	of	ADP
dti-1327	350	20	tr	tr	NOUN
dti-1327	350	21	=	=	PROPN
dti-1327	350	22	15.6–16.3	15.6–16.3	NUM
dti-1327	350	23	min	min	NOUN
dti-1327	350	24	.	.	PROPN
dti-1327	350	25	25	25	NUM
dti-1327	350	26	targeting	target	VERB
dti-1327	350	27	gallium	gallium	NOUN
dti-1327	350	28	to	to	ADP
dti-1327	350	29	cancer	cancer	NOUN
dti-1327	350	30	cells	cell	NOUN
dti-1327	350	31	through	through	ADP
dti-1327	350	32	the	the	DET
dti-1327	350	33	folate	folate	NOUN
dti-1327	350	34	receptor	receptor	NOUN
dti-1327	350	35	drug	drug	NOUN
dti-1327	350	36	target	target	NOUN
dti-1327	350	37	insights	insight	NOUN
dti-1327	350	38	2008:3	2008:3	NUM
dti-1327	350	39	figure	figure	NOUN
dti-1327	350	40	s2	s2	NOUN
dti-1327	350	41	.	.	PUNCT
dti-1327	351	1	cytotoxic	cytotoxic	ADJ
dti-1327	351	2	effects	effect	NOUN
dti-1327	351	3	of	of	ADP
dti-1327	351	4	1	1	NUM
dti-1327	351	5	(	(	PUNCT
dti-1327	351	6	♦	♦	PROPN
dti-1327	351	7	)	)	PUNCT
dti-1327	351	8	,	,	PUNCT
dti-1327	351	9	γ-3	γ-3	PROPN
dti-1327	351	10	(	(	PUNCT
dti-1327	351	11	▲	▲	PUNCT
dti-1327	351	12	)	)	PUNCT
dti-1327	351	13	,	,	PUNCT
dti-1327	351	14	γ-4	γ-4	PROPN
dti-1327	351	15	(	(	PUNCT
dti-1327	351	16	)	)	PUNCT
dti-1327	351	17	and	and	CCONJ
dti-1327	351	18	dota	dota	PROPN
dti-1327	351	19	(	(	PUNCT
dti-1327	351	20	)	)	PUNCT
dti-1327	351	21	against	against	ADP
dti-1327	351	22	cho	cho	NOUN
dti-1327	351	23	cancer	cancer	NOUN
dti-1327	351	24	cells	cell	NOUN
dti-1327	351	25	.	.	PUNCT
dti-1327	352	1	error	error	NOUN
dti-1327	352	2	bars	bar	NOUN
dti-1327	352	3	represent	represent	VERB
dti-1327	352	4	the	the	DET
dti-1327	352	5	standard	standard	ADJ
dti-1327	352	6	deviation	deviation	NOUN
dti-1327	352	7	of	of	ADP
dti-1327	352	8	the	the	DET
dti-1327	352	9	mean	mean	NOUN
dti-1327	352	10	of	of	ADP
dti-1327	352	11	three	three	NUM
dti-1327	352	12	experiments	experiment	NOUN
dti-1327	352	13	(	(	PUNCT
dti-1327	352	14	where	where	SCONJ
dti-1327	352	15	n	n	X
dti-1327	352	16	=	=	SYM
dti-1327	352	17	3	3	NUM
dti-1327	352	18	for	for	ADP
dti-1327	352	19	each	each	DET
dti-1327	352	20	experiment	experiment	NOUN
dti-1327	352	21	)	)	PUNCT
dti-1327	352	22	calculated	calculate	VERB
dti-1327	352	23	for	for	ADP
dti-1327	352	24	each	each	DET
dti-1327	352	25	concentration	concentration	NOUN
dti-1327	352	26	.	.	PUNCT
dti-1327	353	1	lines	line	NOUN
dti-1327	353	2	are	be	AUX
dti-1327	353	3	exponential	exponential	ADJ
dti-1327	353	4	fi	fi	NOUN
dti-1327	353	5	ts	ts	ADP
dti-1327	353	6	with	with	ADP
dti-1327	353	7	r2	r2	PROPN
dti-1327	353	8	values	value	NOUN
dti-1327	353	9	of	of	ADP
dti-1327	353	10	0.8333	0.8333	NUM
dti-1327	353	11	,	,	PUNCT
dti-1327	353	12	0.9982	0.9982	NUM
dti-1327	353	13	,	,	PUNCT
dti-1327	353	14	0.9942	0.9942	NUM
dti-1327	353	15	and	and	CCONJ
dti-1327	353	16	0.9652	0.9652	NUM
dti-1327	353	17	for	for	ADP
dti-1327	353	18	1	1	NUM
dti-1327	353	19	,	,	PUNCT
dti-1327	353	20	γ-3	γ-3	PROPN
dti-1327	353	21	,	,	PUNCT
dti-1327	353	22	γ-4	γ-4	PROPN
dti-1327	353	23	and	and	CCONJ
dti-1327	353	24	dota	dota	PROPN
dti-1327	353	25	respectively	respectively	ADV
dti-1327	353	26	.	.	PUNCT
dti-1327	354	1	figure	figure	NOUN
dti-1327	354	2	s3	s3	PROPN
dti-1327	354	3	.	.	PUNCT
dti-1327	355	1	cytotoxic	cytotoxic	ADJ
dti-1327	355	2	effects	effect	NOUN
dti-1327	355	3	of	of	ADP
dti-1327	355	4	1	1	NUM
dti-1327	355	5	(	(	PUNCT
dti-1327	355	6	♦	♦	PROPN
dti-1327	355	7	)	)	PUNCT
dti-1327	355	8	,	,	PUNCT
dti-1327	355	9	γ-3	γ-3	PROPN
dti-1327	355	10	(	(	PUNCT
dti-1327	355	11	▲	▲	PUNCT
dti-1327	355	12	)	)	PUNCT
dti-1327	355	13	,	,	PUNCT
dti-1327	355	14	γ-4	γ-4	PROPN
dti-1327	355	15	(	(	PUNCT
dti-1327	355	16	)	)	PUNCT
dti-1327	355	17	and	and	CCONJ
dti-1327	355	18	dota	dota	PROPN
dti-1327	355	19	(	(	PUNCT
dti-1327	355	20	)	)	PUNCT
dti-1327	355	21	against	against	ADP
dti-1327	355	22	a2780	a2780	NOUN
dti-1327	355	23	/	/	SYM
dti-1327	355	24	ad	ad	NOUN
dti-1327	355	25	cells	cell	NOUN
dti-1327	355	26	.	.	PUNCT
dti-1327	356	1	error	error	NOUN
dti-1327	356	2	bars	bar	NOUN
dti-1327	356	3	represent	represent	VERB
dti-1327	356	4	the	the	DET
dti-1327	356	5	standard	standard	ADJ
dti-1327	356	6	deviation	deviation	NOUN
dti-1327	356	7	of	of	ADP
dti-1327	356	8	the	the	DET
dti-1327	356	9	mean	mean	NOUN
dti-1327	356	10	of	of	ADP
dti-1327	356	11	three	three	NUM
dti-1327	356	12	experiments	experiment	NOUN
dti-1327	356	13	(	(	PUNCT
dti-1327	356	14	where	where	SCONJ
dti-1327	356	15	n	n	X
dti-1327	356	16	=	=	SYM
dti-1327	356	17	3	3	NUM
dti-1327	356	18	for	for	ADP
dti-1327	356	19	each	each	DET
dti-1327	356	20	experiment	experiment	NOUN
dti-1327	356	21	)	)	PUNCT
dti-1327	356	22	calculated	calculate	VERB
dti-1327	356	23	for	for	ADP
dti-1327	356	24	each	each	DET
dti-1327	356	25	concentration	concentration	NOUN
dti-1327	356	26	.	.	PUNCT
dti-1327	357	1	lines	line	NOUN
dti-1327	357	2	are	be	AUX
dti-1327	357	3	exponential	exponential	ADJ
dti-1327	357	4	fi	fi	NOUN
dti-1327	357	5	ts	ts	ADP
dti-1327	357	6	with	with	ADP
dti-1327	357	7	r2	r2	PROPN
dti-1327	357	8	values	value	NOUN
dti-1327	357	9	of	of	ADP
dti-1327	357	10	0.9905	0.9905	NUM
dti-1327	357	11	,	,	PUNCT
dti-1327	357	12	0.7274	0.7274	NUM
dti-1327	357	13	,	,	PUNCT
dti-1327	357	14	0.9444	0.9444	NUM
dti-1327	357	15	,	,	PUNCT
dti-1327	357	16	and	and	CCONJ
dti-1327	357	17	0.9645	0.9645	NUM
dti-1327	357	18	for	for	ADP
dti-1327	357	19	1	1	NUM
dti-1327	357	20	,	,	PUNCT
dti-1327	357	21	γ-3	γ-3	PROPN
dti-1327	357	22	,	,	PUNCT
dti-1327	357	23	γ-4	γ-4	PROPN
dti-1327	357	24	and	and	CCONJ
dti-1327	357	25	dota	dota	PROPN
dti-1327	357	26	.	.	PUNCT
dti-1327	358	1	0	0	NUM
dti-1327	359	1	20	20	NUM
dti-1327	359	2	40	40	NUM
dti-1327	359	3	60	60	NUM
dti-1327	359	4	80	80	NUM
dti-1327	359	5	100	100	NUM
dti-1327	359	6	120	120	NUM
dti-1327	359	7	140	140	NUM
dti-1327	359	8	%	%	NOUN
dti-1327	360	1	c	c	AUX
dti-1327	360	2	el	el	PROPN
dti-1327	360	3	l	l	PROPN
dti-1327	360	4	v	v	X
dti-1327	360	5	ia	ia	PROPN
dti-1327	360	6	bi	bi	PROPN
dti-1327	360	7	lit	light	VERB
dti-1327	360	8	y	y	NOUN
dti-1327	360	9	0	0	NUM
dti-1327	360	10	20	20	NUM
dti-1327	360	11	40	40	NUM
dti-1327	360	12	60	60	NUM
dti-1327	360	13	80	80	NUM
dti-1327	360	14	100	100	NUM
dti-1327	360	15	120	120	NUM
dti-1327	360	16	0	0	NUM
dti-1327	360	17	0.5	0.5	NUM
dti-1327	360	18	1	1	NUM
dti-1327	360	19	1.5	1.5	NUM
dti-1327	360	20	2	2	NUM
dti-1327	360	21	2.5	2.5	NUM
dti-1327	360	22	%	%	NOUN
dti-1327	361	1	c	c	PROPN
dti-1327	361	2	el	el	PROPN
dti-1327	361	3	l	l	PROPN
dti-1327	361	4	v	v	PROPN
dti-1327	361	5	ia	ia	PROPN
dti-1327	361	6	b	b	NOUN
dti-1327	362	1	i	i	PRON
dti-1327	362	2	lit	light	VERB
dti-1327	362	3	y	y	PROPN
dti-1327	362	4	3	3	NUM
dti-1327	362	5	<	<	X
dti-1327	362	6	<	<	X
dti-1327	362	7	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1327	362	8	false	false	ADJ
dti-1327	362	9	/allowtransparency	/allowtransparency	NOUN
dti-1327	362	10	false	false	ADJ
dti-1327	362	11	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1327	362	12	true	true	ADJ
dti-1327	362	13	/autorotatepages	/autorotatepage	NOUN
dti-1327	362	14	/none	/none	PUNCT
dti-1327	362	15	/binding	/binding	PUNCT
dti-1327	363	1	/left	/left	ADJ
dti-1327	364	1	/calgrayprofile	/calgrayprofile	VERB
dti-1327	364	2	(	(	PUNCT
dti-1327	364	3	dot	dot	NOUN
dti-1327	364	4	gain	gain	NOUN
dti-1327	364	5	20	20	NUM
dti-1327	364	6	%	%	NOUN
dti-1327	364	7	)	)	PUNCT
dti-1327	364	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1327	365	1	(	(	PUNCT
dti-1327	365	2	srgb	srgb	PROPN
dti-1327	365	3	iec61966	iec61966	NOUN
dti-1327	365	4	-	-	PUNCT
dti-1327	365	5	2.1	2.1	NUM
dti-1327	365	6	)	)	PUNCT
dti-1327	365	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1327	366	1	(	(	PUNCT
dti-1327	366	2	u.s	u.s	PROPN
dti-1327	366	3	.	.	PROPN
dti-1327	366	4	web	web	NOUN
dti-1327	366	5	coated	coat	VERB
dti-1327	366	6	\050swop\051	\050swop\051	ADJ
dti-1327	366	7	v2	v2	NOUN
dti-1327	366	8	)	)	PUNCT
dti-1327	366	9	/srgbprofile	/srgbprofile	PUNCT
dti-1327	366	10	(	(	PUNCT
dti-1327	366	11	srgb	srgb	PROPN
dti-1327	366	12	iec61966	iec61966	NOUN
dti-1327	366	13	-	-	PUNCT
dti-1327	366	14	2.1	2.1	NUM
dti-1327	366	15	)	)	PUNCT
dti-1327	366	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1327	367	1	/error	/error	INTJ
dti-1327	367	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1327	368	1	1.4	1.4	NUM
dti-1327	368	2	/compressobjects	/compressobject	NOUN
dti-1327	368	3	/tags	/tag	VERB
dti-1327	368	4	/compresspages	/compresspage	NOUN
dti-1327	368	5	true	true	ADJ
dti-1327	368	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1327	368	7	true	true	ADJ
dti-1327	368	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1327	368	9	true	true	ADJ
dti-1327	368	10	/createjdffile	/createjdffile	ADJ
dti-1327	368	11	false	false	ADJ
dti-1327	368	12	/createjobticket	/createjobticket	NOUN
dti-1327	368	13	false	false	ADJ
dti-1327	368	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1327	368	15	/default	/default	PUNCT
dti-1327	368	16	/detectblends	/detectblend	NOUN
dti-1327	368	17	true	true	ADJ
dti-1327	368	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1327	368	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1327	368	20	/dothumbnails	/dothumbnail	VERB
dti-1327	368	21	false	false	ADJ
dti-1327	368	22	/embedallfonts	/embedallfont	NOUN
dti-1327	368	23	true	true	ADJ
dti-1327	368	24	/embedjoboptions	/embedjoboption	NOUN
dti-1327	368	25	true	true	ADJ
dti-1327	368	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1327	368	27	0	0	NUM
dti-1327	368	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1327	368	29	false	false	ADJ
dti-1327	368	30	/endpage	/endpage	NOUN
dti-1327	368	31	-1	-1	NOUN
dti-1327	368	32	/imagememory	/imagememory	NUM
dti-1327	369	1	1048576	1048576	NUM
dti-1327	369	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1327	369	3	false	false	ADJ
dti-1327	369	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1327	369	5	100	100	NUM
dti-1327	369	6	/optimize	/optimize	NOUN
dti-1327	369	7	true	true	ADJ
dti-1327	369	8	/opm	/opm	NOUN
dti-1327	369	9	1	1	NUM
dti-1327	369	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1327	369	11	true	true	ADJ
dti-1327	369	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1327	369	13	true	true	ADJ
dti-1327	369	14	/preservecopypage	/preservecopypage	NOUN
dti-1327	369	15	true	true	ADJ
dti-1327	369	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1327	369	17	true	true	ADJ
dti-1327	369	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1327	369	19	false	false	ADJ
dti-1327	369	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1327	369	21	false	false	ADJ
dti-1327	369	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1327	369	23	true	true	ADJ
dti-1327	369	24	/startpage	/startpage	NOUN
dti-1327	369	25	1	1	NUM
dti-1327	369	26	/subsetfonts	/subsetfont	NOUN
dti-1327	369	27	true	true	ADJ
dti-1327	369	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1327	369	29	/apply	/apply	PUNCT
dti-1327	369	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1327	370	1	/preserve	/preserve	NOUN
dti-1327	370	2	/useprologue	/useprologue	NOUN
dti-1327	370	3	false	false	ADJ
dti-1327	370	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1327	370	5	(	(	PUNCT
dti-1327	370	6	)	)	PUNCT
dti-1327	370	7	/alwaysembed	/alwaysembe	VERB
dti-1327	370	8	[	[	PUNCT
dti-1327	370	9	true	true	ADJ
dti-1327	370	10	]	]	PUNCT
dti-1327	370	11	/neverembed	/neverembed	PUNCT
dti-1327	371	1	[	[	PUNCT
dti-1327	371	2	true	true	ADJ
dti-1327	371	3	]	]	PUNCT
dti-1327	371	4	/antialiascolorimages	/antialiascolorimages	X
dti-1327	371	5	false	false	ADJ
dti-1327	371	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1327	371	7	true	true	ADJ
dti-1327	371	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1327	371	9	/bicubic	/bicubic	NOUN
dti-1327	371	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1327	371	11	300	300	NUM
dti-1327	371	12	/colorimagedepth	/colorimagedepth	PRON
dti-1327	372	1	-1	-1	INTJ
dti-1327	372	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1327	372	3	1.50000	1.50000	NUM
dti-1327	372	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1327	372	5	true	true	ADJ
dti-1327	372	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1327	372	7	/dctencode	/dctencode	PUNCT
dti-1327	372	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1327	372	9	true	true	ADJ
dti-1327	372	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1327	372	11	/jpeg	/jpeg	PUNCT
dti-1327	372	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1327	373	1	<	<	X
dti-1327	373	2	<	<	X
dti-1327	373	3	/qfactor	/qfactor	NOUN
dti-1327	373	4	0.15	0.15	NUM
dti-1327	373	5	/hsamples	/hsample	NOUN
dti-1327	374	1	[	[	X
dti-1327	374	2	1	1	NUM
dti-1327	374	3	1	1	NUM
dti-1327	374	4	1	1	NUM
dti-1327	374	5	1	1	NUM
dti-1327	374	6	]	]	PUNCT
dti-1327	374	7	/vsamples	/vsample	NOUN
dti-1327	375	1	[	[	X
dti-1327	375	2	1	1	NUM
dti-1327	375	3	1	1	NUM
dti-1327	375	4	1	1	NUM
dti-1327	375	5	1	1	NUM
dti-1327	375	6	]	]	PUNCT
dti-1327	375	7	>	>	PUNCT
dti-1327	375	8	>	>	X
dti-1327	375	9	/colorimagedict	/colorimagedict	PUNCT
dti-1327	376	1	<	<	X
dti-1327	376	2	<	<	X
dti-1327	376	3	/qfactor	/qfactor	NOUN
dti-1327	376	4	0.15	0.15	NUM
dti-1327	376	5	/hsamples	/hsample	NOUN
dti-1327	377	1	[	[	X
dti-1327	377	2	1	1	NUM
dti-1327	377	3	1	1	NUM
dti-1327	377	4	1	1	NUM
dti-1327	377	5	1	1	NUM
dti-1327	377	6	]	]	PUNCT
dti-1327	377	7	/vsamples	/vsample	NOUN
dti-1327	378	1	[	[	X
dti-1327	378	2	1	1	NUM
dti-1327	378	3	1	1	NUM
dti-1327	378	4	1	1	NUM
dti-1327	378	5	1	1	NUM
dti-1327	378	6	]	]	PUNCT
dti-1327	378	7	>	>	PUNCT
dti-1327	378	8	>	>	X
dti-1327	378	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1327	379	1	<	<	X
dti-1327	379	2	<	<	X
dti-1327	379	3	/tilewidth	/tilewidth	PUNCT
dti-1327	379	4	256	256	NUM
dti-1327	379	5	/tileheight	/tileheight	NUM
dti-1327	379	6	256	256	NUM
dti-1327	379	7	/quality	/quality	NOUN
dti-1327	379	8	30	30	NUM
dti-1327	379	9	>	>	PUNCT
dti-1327	379	10	>	>	X
dti-1327	379	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1327	379	12	<	<	X
dti-1327	379	13	<	<	X
dti-1327	379	14	/tilewidth	/tilewidth	PUNCT
dti-1327	379	15	256	256	NUM
dti-1327	379	16	/tileheight	/tileheight	NUM
dti-1327	379	17	256	256	NUM
dti-1327	379	18	/quality	/quality	NOUN
dti-1327	379	19	30	30	NUM
dti-1327	379	20	>	>	PUNCT
dti-1327	379	21	>	>	X
dti-1327	379	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1327	379	23	false	false	ADJ
dti-1327	379	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1327	380	1	true	true	ADJ
dti-1327	380	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1327	380	3	/bicubic	/bicubic	NOUN
dti-1327	380	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1327	380	5	300	300	NUM
dti-1327	380	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1327	380	7	-1	-1	PUNCT
dti-1327	380	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1327	381	1	1.50000	1.50000	NUM
dti-1327	381	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1327	381	3	true	true	ADJ
dti-1327	381	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1327	381	5	/dctencode	/dctencode	PUNCT
dti-1327	382	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1327	382	2	true	true	ADJ
dti-1327	382	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1327	382	4	/jpeg	/jpeg	PUNCT
dti-1327	382	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1327	383	1	<	<	X
dti-1327	383	2	<	<	X
dti-1327	383	3	/qfactor	/qfactor	NOUN
dti-1327	383	4	0.15	0.15	NUM
dti-1327	383	5	/hsamples	/hsample	NOUN
dti-1327	384	1	[	[	X
dti-1327	384	2	1	1	NUM
dti-1327	384	3	1	1	NUM
dti-1327	384	4	1	1	NUM
dti-1327	384	5	1	1	NUM
dti-1327	384	6	]	]	PUNCT
dti-1327	384	7	/vsamples	/vsample	NOUN
dti-1327	385	1	[	[	X
dti-1327	385	2	1	1	NUM
dti-1327	385	3	1	1	NUM
dti-1327	385	4	1	1	NUM
dti-1327	385	5	1	1	NUM
dti-1327	385	6	]	]	PUNCT
dti-1327	385	7	>	>	PUNCT
dti-1327	385	8	>	>	X
dti-1327	385	9	/grayimagedict	/grayimagedict	PUNCT
dti-1327	386	1	<	<	X
dti-1327	386	2	<	<	X
dti-1327	386	3	/qfactor	/qfactor	NOUN
dti-1327	386	4	0.15	0.15	NUM
dti-1327	386	5	/hsamples	/hsample	NOUN
dti-1327	387	1	[	[	X
dti-1327	387	2	1	1	NUM
dti-1327	387	3	1	1	NUM
dti-1327	387	4	1	1	NUM
dti-1327	387	5	1	1	NUM
dti-1327	387	6	]	]	PUNCT
dti-1327	387	7	/vsamples	/vsample	NOUN
dti-1327	388	1	[	[	X
dti-1327	388	2	1	1	NUM
dti-1327	388	3	1	1	NUM
dti-1327	388	4	1	1	NUM
dti-1327	388	5	1	1	NUM
dti-1327	388	6	]	]	PUNCT
dti-1327	388	7	>	>	X
dti-1327	388	8	>	>	X
dti-1327	388	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1327	389	1	<	<	X
dti-1327	389	2	<	<	X
dti-1327	389	3	/tilewidth	/tilewidth	PUNCT
dti-1327	389	4	256	256	NUM
dti-1327	389	5	/tileheight	/tileheight	NUM
dti-1327	389	6	256	256	NUM
dti-1327	389	7	/quality	/quality	NOUN
dti-1327	389	8	30	30	NUM
dti-1327	389	9	>	>	PUNCT
dti-1327	389	10	>	>	X
dti-1327	389	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1327	389	12	<	<	X
dti-1327	389	13	<	<	X
dti-1327	389	14	/tilewidth	/tilewidth	PUNCT
dti-1327	389	15	256	256	NUM
dti-1327	389	16	/tileheight	/tileheight	NUM
dti-1327	389	17	256	256	NUM
dti-1327	389	18	/quality	/quality	NOUN
dti-1327	389	19	30	30	NUM
dti-1327	389	20	>	>	PUNCT
dti-1327	389	21	>	>	X
dti-1327	389	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1327	389	23	false	false	ADJ
dti-1327	389	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1327	389	25	true	true	ADJ
dti-1327	389	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1327	389	27	/bicubic	/bicubic	NOUN
dti-1327	389	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1327	389	29	1200	1200	NUM
dti-1327	389	30	/monoimagedepth	/monoimagedepth	PRON
dti-1327	389	31	-1	-1	PUNCT
dti-1327	389	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1327	389	33	1.50000	1.50000	NUM
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dti-1327	404	12	setdistillerparams	setdistillerparam	NOUN
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dti-1327	407	7	setpagedevice	setpagedevice	PROPN