id	sid	tid	token	lemma	pos
dti-1331	1	1	moretti	moretti	PROPN
dti-1331	1	2	et	et	PROPN
dti-1331	1	3	al.indd	al.indd	X
dti-1331	1	4	drug	drug	NOUN
dti-1331	1	5	target	target	NOUN
dti-1331	1	6	insights	insight	NOUN
dti-1331	1	7	2008:3	2008:3	NUM
dti-1331	1	8	77–85	77–85	NUM
dti-1331	1	9	77	77	NUM
dti-1331	1	10	review	review	NOUN
dti-1331	1	11	correspondence	correspondence	NOUN
dti-1331	1	12	:	:	PUNCT
dti-1331	1	13	rita	rita	PROPN
dti-1331	1	14	moretti	moretti	PROPN
dti-1331	1	15	,	,	PUNCT
dti-1331	1	16	m.d	m.d	PROPN
dti-1331	1	17	.	.	PROPN
dti-1331	1	18	,	,	PUNCT
dti-1331	1	19	department	department	PROPN
dti-1331	1	20	of	of	ADP
dti-1331	1	21	neurology	neurology	NOUN
dti-1331	1	22	,	,	PUNCT
dti-1331	1	23	university	university	NOUN
dti-1331	1	24	of	of	ADP
dti-1331	1	25	trieste	trieste	PROPN
dti-1331	1	26	,	,	PUNCT
dti-1331	1	27	cattinara	cattinara	PROPN
dti-1331	1	28	hospital	hospital	PROPN
dti-1331	1	29	34149	34149	NUM
dti-1331	1	30	trieste	trieste	PROPN
dti-1331	1	31	,	,	PUNCT
dti-1331	1	32	italy	italy	PROPN
dti-1331	1	33	.	.	PUNCT
dti-1331	2	1	tel	tel	ADP
dti-1331	2	2	:	:	PUNCT
dti-1331	2	3	+39	+39	PROPN
dti-1331	2	4	-	-	PUNCT
dti-1331	2	5	40	40	NUM
dti-1331	2	6	-	-	PUNCT
dti-1331	2	7	3994321	3994321	NUM
dti-1331	2	8	;	;	PUNCT
dti-1331	2	9	fax	fax	NOUN
dti-1331	2	10	:	:	PUNCT
dti-1331	2	11	+39	+39	PROPN
dti-1331	2	12	-	-	PUNCT
dti-1331	2	13	40	40	NUM
dti-1331	2	14	-	-	PUNCT
dti-1331	2	15	910861	910861	NUM
dti-1331	2	16	;	;	PUNCT
dti-1331	2	17	email	email	NOUN
dti-1331	2	18	:	:	PUNCT
dti-1331	2	19	moretti@univ.trieste.it	moretti@univ.trieste.it	PRON
dti-1331	2	20	copyright	copyright	NOUN
dti-1331	2	21	in	in	ADP
dti-1331	2	22	this	this	DET
dti-1331	2	23	article	article	NOUN
dti-1331	2	24	,	,	PUNCT
dti-1331	2	25	its	its	PRON
dti-1331	2	26	metadata	metadata	NOUN
dti-1331	2	27	,	,	PUNCT
dti-1331	2	28	and	and	CCONJ
dti-1331	2	29	any	any	DET
dti-1331	2	30	supplementary	supplementary	ADJ
dti-1331	2	31	data	datum	NOUN
dti-1331	2	32	is	be	AUX
dti-1331	2	33	held	hold	VERB
dti-1331	2	34	by	by	ADP
dti-1331	2	35	its	its	PRON
dti-1331	2	36	author	author	NOUN
dti-1331	2	37	or	or	CCONJ
dti-1331	2	38	authors	author	NOUN
dti-1331	2	39	.	.	PUNCT
dti-1331	3	1	it	it	PRON
dti-1331	3	2	is	be	AUX
dti-1331	3	3	published	publish	VERB
dti-1331	3	4	under	under	ADP
dti-1331	3	5	the	the	DET
dti-1331	3	6	creative	creative	ADJ
dti-1331	3	7	commons	common	NOUN
dti-1331	3	8	attribution	attribution	NOUN
dti-1331	3	9	by	by	ADP
dti-1331	3	10	licence	licence	NOUN
dti-1331	3	11	.	.	PUNCT
dti-1331	4	1	for	for	SCONJ
dti-1331	4	2	further	further	ADJ
dti-1331	4	3	information	information	NOUN
dti-1331	4	4	go	go	VERB
dti-1331	4	5	to	to	ADP
dti-1331	4	6	:	:	PUNCT
dti-1331	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1331	4	8	memantine	memantine	NOUN
dti-1331	4	9	:	:	PUNCT
dti-1331	4	10	reality	reality	NOUN
dti-1331	4	11	and	and	CCONJ
dti-1331	4	12	potentiality	potentiality	NOUN
dti-1331	4	13	rita	rita	PROPN
dti-1331	4	14	moretti	moretti	PROPN
dti-1331	4	15	,	,	PUNCT
dti-1331	4	16	paola	paola	PROPN
dti-1331	4	17	torre	torre	PROPN
dti-1331	4	18	,	,	PUNCT
dti-1331	4	19	cristina	cristina	PROPN
dti-1331	4	20	vilotti	vilotti	PROPN
dti-1331	4	21	,	,	PUNCT
dti-1331	4	22	davide	davide	NOUN
dti-1331	4	23	manganaro	manganaro	NOUN
dti-1331	4	24	,	,	PUNCT
dti-1331	4	25	luca	luca	PROPN
dti-1331	4	26	zanet	zanet	PROPN
dti-1331	4	27	and	and	CCONJ
dti-1331	4	28	rodolfo	rodolfo	PROPN
dti-1331	4	29	m.	m.	PROPN
dti-1331	4	30	antonello	antonello	PROPN
dti-1331	4	31	department	department	PROPN
dti-1331	4	32	of	of	ADP
dti-1331	4	33	medicine	medicine	NOUN
dti-1331	4	34	and	and	CCONJ
dti-1331	4	35	neurology	neurology	NOUN
dti-1331	4	36	,	,	PUNCT
dti-1331	4	37	university	university	NOUN
dti-1331	4	38	of	of	ADP
dti-1331	4	39	trieste	trieste	PROPN
dti-1331	4	40	,	,	PUNCT
dti-1331	4	41	trieste	trieste	PROPN
dti-1331	4	42	,	,	PUNCT
dti-1331	4	43	italy	italy	PROPN
dti-1331	4	44	.	.	PUNCT
dti-1331	5	1	abstract	abstract	ADJ
dti-1331	5	2	:	:	PUNCT
dti-1331	5	3	memantine	memantine	NOUN
dti-1331	5	4	protects	protect	VERB
dti-1331	5	5	cultured	cultured	ADJ
dti-1331	5	6	neurons	neuron	NOUN
dti-1331	5	7	from	from	ADP
dti-1331	5	8	excitotoxin	excitotoxin	PROPN
dti-1331	5	9	-	-	PUNCT
dti-1331	5	10	induced	induce	VERB
dti-1331	5	11	cell	cell	NOUN
dti-1331	5	12	-	-	PUNCT
dti-1331	5	13	death	death	NOUN
dti-1331	5	14	;	;	PUNCT
dti-1331	5	15	it	it	PRON
dti-1331	5	16	attenuated	attenuate	VERB
dti-1331	5	17	loss	loss	NOUN
dti-1331	5	18	of	of	ADP
dti-1331	5	19	cholinergic	cholinergic	ADJ
dti-1331	5	20	neurons	neuron	NOUN
dti-1331	5	21	in	in	ADP
dti-1331	5	22	the	the	DET
dti-1331	5	23	cns	cns	NOUN
dti-1331	5	24	induced	induce	VERB
dti-1331	5	25	by	by	ADP
dti-1331	5	26	injection	injection	NOUN
dti-1331	5	27	of	of	ADP
dti-1331	5	28	nmda	nmda	NOUN
dti-1331	5	29	into	into	ADP
dti-1331	5	30	the	the	DET
dti-1331	5	31	basal	basal	ADJ
dti-1331	5	32	forebrain	forebrain	NOUN
dti-1331	5	33	of	of	ADP
dti-1331	5	34	rats	rat	NOUN
dti-1331	5	35	.	.	PUNCT
dti-1331	6	1	it	it	PRON
dti-1331	6	2	has	have	AUX
dti-1331	6	3	been	be	AUX
dti-1331	6	4	shown	show	VERB
dti-1331	6	5	that	that	SCONJ
dti-1331	6	6	memantine	memantine	ADJ
dti-1331	6	7	induced	induce	VERB
dti-1331	6	8	production	production	NOUN
dti-1331	6	9	of	of	ADP
dti-1331	6	10	brain	brain	NOUN
dti-1331	6	11	-	-	PUNCT
dti-1331	6	12	derived	derive	VERB
dti-1331	6	13	neurotrophic	neurotrophic	ADJ
dti-1331	6	14	factor	factor	NOUN
dti-1331	6	15	(	(	PUNCT
dti-1331	6	16	bdnf	bdnf	PROPN
dti-1331	6	17	)	)	PUNCT
dti-1331	6	18	,	,	PUNCT
dti-1331	6	19	a	a	DET
dti-1331	6	20	substance	substance	NOUN
dti-1331	6	21	shown	show	VERB
dti-1331	6	22	to	to	PART
dti-1331	6	23	promote	promote	VERB
dti-1331	6	24	survival	survival	NOUN
dti-1331	6	25	and	and	CCONJ
dti-1331	6	26	differentiation	differentiation	NOUN
dti-1331	6	27	of	of	ADP
dti-1331	6	28	cns	cns	PROPN
dti-1331	6	29	neuron	neuron	PROPN
dti-1331	6	30	.	.	PUNCT
dti-1331	7	1	due	due	ADP
dti-1331	7	2	to	to	ADP
dti-1331	7	3	the	the	DET
dti-1331	7	4	preclinical	preclinical	ADJ
dti-1331	7	5	effects	effect	NOUN
dti-1331	7	6	of	of	ADP
dti-1331	7	7	memantine	memantine	NOUN
dti-1331	7	8	owing	owe	VERB
dti-1331	7	9	to	to	ADP
dti-1331	7	10	its	its	PRON
dti-1331	7	11	anti	anti	ADJ
dti-1331	7	12	-	-	ADJ
dti-1331	7	13	ischemic	ischemic	ADJ
dti-1331	7	14	and	and	CCONJ
dti-1331	7	15	anti	anti	ADJ
dti-1331	7	16	-	-	ADJ
dti-1331	7	17	excitotoxic	excitotoxic	ADJ
dti-1331	7	18	properties	property	NOUN
dti-1331	7	19	,	,	PUNCT
dti-1331	7	20	recent	recent	ADJ
dti-1331	7	21	clinical	clinical	ADJ
dti-1331	7	22	effi	effi	PROPN
dti-1331	7	23	cacy	cacy	NOUN
dti-1331	7	24	has	have	AUX
dti-1331	7	25	been	be	AUX
dti-1331	7	26	demonstrated	demonstrate	VERB
dti-1331	7	27	in	in	ADP
dti-1331	7	28	patients	patient	NOUN
dti-1331	7	29	with	with	ADP
dti-1331	7	30	advanced	advanced	ADJ
dti-1331	7	31	dementia	dementia	NOUN
dti-1331	7	32	of	of	ADP
dti-1331	7	33	vascular	vascular	ADJ
dti-1331	7	34	origins	origin	NOUN
dti-1331	7	35	.	.	PUNCT
dti-1331	8	1	therefore	therefore	ADV
dti-1331	8	2	,	,	PUNCT
dti-1331	8	3	it	it	PRON
dti-1331	8	4	has	have	AUX
dti-1331	8	5	been	be	AUX
dti-1331	8	6	employed	employ	VERB
dti-1331	8	7	in	in	ADP
dti-1331	8	8	different	different	ADJ
dti-1331	8	9	trials	trial	NOUN
dti-1331	8	10	,	,	PUNCT
dti-1331	8	11	in	in	ADP
dti-1331	8	12	vascular	vascular	ADJ
dti-1331	8	13	dementia	dementia	NOUN
dti-1331	8	14	,	,	PUNCT
dti-1331	8	15	showing	show	VERB
dti-1331	8	16	a	a	DET
dti-1331	8	17	potential	potential	ADJ
dti-1331	8	18	benefi	benefi	NOUN
dti-1331	8	19	t	t	PROPN
dti-1331	8	20	and	and	CCONJ
dti-1331	8	21	no	no	DET
dti-1331	8	22	unbearable	unbearable	ADJ
dti-1331	8	23	side	side	NOUN
dti-1331	8	24	effects	effect	NOUN
dti-1331	8	25	.	.	PUNCT
dti-1331	9	1	different	different	ADJ
dti-1331	9	2	studies	study	NOUN
dti-1331	9	3	underline	underline	VERB
dti-1331	9	4	the	the	DET
dti-1331	9	5	possible	possible	ADJ
dti-1331	9	6	role	role	NOUN
dti-1331	9	7	of	of	ADP
dti-1331	9	8	memantine	memantine	NOUN
dti-1331	9	9	in	in	ADP
dti-1331	9	10	parkinson	parkinson	NOUN
dti-1331	9	11	disease	disease	NOUN
dti-1331	9	12	.	.	PUNCT
dti-1331	10	1	keywords	keyword	NOUN
dti-1331	10	2	:	:	PUNCT
dti-1331	10	3	memantine	memantine	ADJ
dti-1331	10	4	,	,	PUNCT
dti-1331	10	5	nmda	nmda	ADJ
dti-1331	10	6	,	,	PUNCT
dti-1331	10	7	glutamate	glutamate	NOUN
dti-1331	10	8	,	,	PUNCT
dti-1331	10	9	degeneration	degeneration	NOUN
dti-1331	10	10	glutamate	glutamate	NOUN
dti-1331	10	11	is	be	AUX
dti-1331	10	12	the	the	DET
dti-1331	10	13	principal	principal	ADJ
dti-1331	10	14	excitatory	excitatory	NOUN
dti-1331	10	15	neurotransmitter	neurotransmitter	NOUN
dti-1331	10	16	in	in	ADP
dti-1331	10	17	the	the	DET
dti-1331	10	18	brain	brain	NOUN
dti-1331	10	19	and	and	CCONJ
dti-1331	10	20	is	be	AUX
dti-1331	10	21	active	active	ADJ
dti-1331	10	22	in	in	ADP
dti-1331	10	23	about	about	ADV
dti-1331	10	24	one	one	NUM
dti-1331	10	25	-	-	PUNCT
dti-1331	10	26	third	third	NOUN
dti-1331	10	27	of	of	ADP
dti-1331	10	28	all	all	DET
dti-1331	10	29	the	the	DET
dti-1331	10	30	synapses	synapsis	NOUN
dti-1331	10	31	in	in	ADP
dti-1331	10	32	the	the	DET
dti-1331	10	33	central	central	ADJ
dti-1331	10	34	nervous	nervous	ADJ
dti-1331	10	35	system	system	NOUN
dti-1331	10	36	.	.	PUNCT
dti-1331	11	1	although	although	SCONJ
dti-1331	11	2	glutamate	glutamate	NOUN
dti-1331	11	3	is	be	AUX
dti-1331	11	4	a	a	DET
dti-1331	11	5	crucial	crucial	ADJ
dti-1331	11	6	mediator	mediator	NOUN
dti-1331	11	7	of	of	ADP
dti-1331	11	8	physiological	physiological	ADJ
dti-1331	11	9	communication	communication	NOUN
dti-1331	11	10	between	between	ADP
dti-1331	11	11	neuronal	neuronal	ADJ
dti-1331	11	12	cells	cell	NOUN
dti-1331	11	13	,	,	PUNCT
dti-1331	11	14	under	under	ADP
dti-1331	11	15	certain	certain	ADJ
dti-1331	11	16	conditions	condition	NOUN
dti-1331	11	17	activation	activation	NOUN
dti-1331	11	18	of	of	ADP
dti-1331	11	19	glutamate	glutamate	ADJ
dti-1331	11	20	receptors	receptor	NOUN
dti-1331	11	21	kills	kill	VERB
dti-1331	11	22	neurones	neurone	NOUN
dti-1331	11	23	—	—	PUNCT
dti-1331	11	24	a	a	DET
dti-1331	11	25	term	term	NOUN
dti-1331	11	26	called	call	VERB
dti-1331	11	27	“	"	PUNCT
dti-1331	11	28	excitotoxicity	excitotoxicity	NOUN
dti-1331	11	29	”	"	PUNCT
dti-1331	11	30	(	(	PUNCT
dti-1331	11	31	rothman	rothman	PROPN
dti-1331	11	32	et	et	PROPN
dti-1331	11	33	al	al	PROPN
dti-1331	11	34	.	.	PROPN
dti-1331	11	35	1987	1987	NUM
dti-1331	11	36	)	)	PUNCT
dti-1331	11	37	.	.	PUNCT
dti-1331	12	1	it	it	PRON
dti-1331	12	2	has	have	AUX
dti-1331	12	3	been	be	AUX
dti-1331	12	4	implied	imply	VERB
dti-1331	12	5	that	that	SCONJ
dti-1331	12	6	excitotoxicity	excitotoxicity	NOUN
dti-1331	12	7	is	be	AUX
dti-1331	12	8	involved	involve	VERB
dti-1331	12	9	in	in	ADP
dti-1331	12	10	many	many	ADJ
dti-1331	12	11	types	type	NOUN
dti-1331	12	12	of	of	ADP
dti-1331	12	13	acute	acute	ADJ
dti-1331	12	14	and	and	CCONJ
dti-1331	12	15	chronic	chronic	ADJ
dti-1331	12	16	cns	cns	NOUN
dti-1331	12	17	neurodegenerative	neurodegenerative	ADJ
dti-1331	12	18	disorders	disorder	NOUN
dti-1331	12	19	and	and	CCONJ
dti-1331	12	20	is	be	AUX
dti-1331	12	21	connected	connect	VERB
dti-1331	12	22	with	with	ADP
dti-1331	12	23	ca2	ca2	PROPN
dti-1331	12	24	+	+	PROPN
dti-1331	12	25	overload	overload	NOUN
dti-1331	12	26	(	(	PUNCT
dti-1331	12	27	choi	choi	NOUN
dti-1331	12	28	et	et	PROPN
dti-1331	12	29	al	al	PROPN
dti-1331	12	30	.	.	PROPN
dti-1331	12	31	1995	1995	NUM
dti-1331	12	32	)	)	PUNCT
dti-1331	12	33	.	.	PUNCT
dti-1331	13	1	disturbance	disturbance	NOUN
dti-1331	13	2	of	of	ADP
dti-1331	13	3	glutamate	glutamate	ADJ
dti-1331	13	4	homeostasis	homeostasis	NOUN
dti-1331	13	5	probably	probably	ADV
dti-1331	13	6	plays	play	VERB
dti-1331	13	7	a	a	DET
dti-1331	13	8	pivotal	pivotal	ADJ
dti-1331	13	9	role	role	NOUN
dti-1331	13	10	in	in	ADP
dti-1331	13	11	neuropathology	neuropathology	NOUN
dti-1331	13	12	triggered	trigger	VERB
dti-1331	13	13	by	by	ADP
dti-1331	13	14	other	other	ADJ
dti-1331	13	15	factors	factor	NOUN
dti-1331	13	16	such	such	ADJ
dti-1331	13	17	as	as	ADP
dti-1331	13	18	:	:	PUNCT
dti-1331	13	19	energy	energy	NOUN
dti-1331	13	20	defi	defi	PROPN
dti-1331	13	21	cits	cit	NOUN
dti-1331	13	22	,	,	PUNCT
dti-1331	13	23	free	free	ADJ
dti-1331	13	24	radicals	radical	NOUN
dti-1331	13	25	formation	formation	NOUN
dti-1331	13	26	,	,	PUNCT
dti-1331	13	27	etc	etc	X
dti-1331	13	28	.	.	X
dti-1331	13	29	that	that	PRON
dti-1331	13	30	facilitate	facilitate	VERB
dti-1331	13	31	the	the	DET
dti-1331	13	32	neurotoxic	neurotoxic	ADJ
dti-1331	13	33	potential	potential	NOUN
dti-1331	13	34	of	of	ADP
dti-1331	13	35	endogenous	endogenous	ADJ
dti-1331	13	36	glutamate	glutamate	NOUN
dti-1331	13	37	(	(	PUNCT
dti-1331	13	38	danysz	danysz	NOUN
dti-1331	13	39	et	et	PROPN
dti-1331	13	40	al	al	PROPN
dti-1331	13	41	.	.	PROPN
dti-1331	13	42	2000	2000	NUM
dti-1331	13	43	)	)	PUNCT
dti-1331	13	44	.	.	PUNCT
dti-1331	14	1	glutamate	glutamate	NOUN
dti-1331	14	2	activates	activate	VERB
dti-1331	14	3	three	three	NUM
dti-1331	14	4	major	major	ADJ
dti-1331	14	5	types	type	NOUN
dti-1331	14	6	of	of	ADP
dti-1331	14	7	ionotropic	ionotropic	ADJ
dti-1331	14	8	receptors	receptor	NOUN
dti-1331	14	9	,	,	PUNCT
dti-1331	14	10	namely	namely	ADV
dti-1331	14	11	a	a	PRON
dti-1331	14	12	-	-	PUNCT
dti-1331	14	13	amino-3hydroxy-5	amino-3hydroxy-5	VERB
dti-1331	14	14	-	-	PUNCT
dti-1331	14	15	methyl4	methyl4	NOUN
dti-1331	14	16	-	-	PUNCT
dti-1331	14	17	isoxazolepropionic	isoxazolepropionic	NOUN
dti-1331	14	18	acid	acid	NOUN
dti-1331	14	19	(	(	PUNCT
dti-1331	14	20	ampa	ampa	PROPN
dti-1331	14	21	)	)	PUNCT
dti-1331	14	22	,	,	PUNCT
dti-1331	14	23	kainate	kainate	NOUN
dti-1331	14	24	and	and	CCONJ
dti-1331	14	25	n	n	CCONJ
dti-1331	14	26	-	-	PUNCT
dti-1331	14	27	methyl	methyl	NOUN
dti-1331	14	28	-	-	PUNCT
dti-1331	14	29	d	d	NOUN
dti-1331	14	30	-	-	NOUN
dti-1331	14	31	aspartate	aspartate	NOUN
dti-1331	14	32	(	(	PUNCT
dti-1331	14	33	nmda	nmda	ADJ
dti-1331	14	34	)	)	PUNCT
dti-1331	14	35	and	and	CCONJ
dti-1331	14	36	several	several	ADJ
dti-1331	14	37	types	type	NOUN
dti-1331	14	38	of	of	ADP
dti-1331	14	39	metabotropic	metabotropic	NOUN
dti-1331	14	40	receptors	receptor	NOUN
dti-1331	14	41	.	.	PUNCT
dti-1331	15	1	ampa	ampa	NOUN
dti-1331	15	2	receptors	receptor	NOUN
dti-1331	15	3	are	be	AUX
dti-1331	15	4	probably	probably	ADV
dti-1331	15	5	involved	involve	VERB
dti-1331	15	6	in	in	ADP
dti-1331	15	7	all	all	DET
dti-1331	15	8	forms	form	NOUN
dti-1331	15	9	of	of	ADP
dti-1331	15	10	fast	fast	ADJ
dti-1331	15	11	glutamatergic	glutamatergic	ADJ
dti-1331	15	12	neurotransmission	neurotransmission	NOUN
dti-1331	15	13	(	(	PUNCT
dti-1331	15	14	danysz	danysz	NOUN
dti-1331	15	15	et	et	PROPN
dti-1331	15	16	al	al	PROPN
dti-1331	15	17	.	.	PROPN
dti-1331	15	18	2000	2000	NUM
dti-1331	15	19	)	)	PUNCT
dti-1331	15	20	.	.	PUNCT
dti-1331	16	1	there	there	PRON
dti-1331	16	2	are	be	VERB
dti-1331	16	3	four	four	NUM
dti-1331	16	4	known	know	VERB
dti-1331	16	5	subunits	subunit	NOUN
dti-1331	16	6	glur1	glur1	PROPN
dti-1331	16	7	to	to	ADP
dti-1331	16	8	glur4	glur4	PROPN
dti-1331	16	9	which	which	PRON
dti-1331	16	10	form	form	VERB
dti-1331	16	11	functional	functional	ADJ
dti-1331	16	12	receptors	receptor	NOUN
dti-1331	16	13	as	as	ADP
dti-1331	16	14	tetrameric	tetrameric	ADJ
dti-1331	16	15	subunit	subunit	NOUN
dti-1331	16	16	assemblies	assembly	NOUN
dti-1331	16	17	.	.	PUNCT
dti-1331	17	1	all	all	DET
dti-1331	17	2	ampa	ampa	NOUN
dti-1331	17	3	receptors	receptor	NOUN
dti-1331	17	4	are	be	AUX
dti-1331	17	5	permeable	permeable	ADJ
dti-1331	17	6	to	to	ADP
dti-1331	17	7	na+	na+	ADV
dti-1331	17	8	and	and	CCONJ
dti-1331	17	9	k+	k+	NOUN
dti-1331	17	10	while	while	SCONJ
dti-1331	17	11	complexes	complex	NOUN
dti-1331	17	12	lacking	lack	VERB
dti-1331	17	13	glur2	glur2	NOUN
dti-1331	17	14	subunits	subunit	NOUN
dti-1331	17	15	are	be	AUX
dti-1331	17	16	also	also	ADV
dti-1331	17	17	permeable	permeable	ADJ
dti-1331	17	18	to	to	ADP
dti-1331	17	19	ca2	ca2	PROPN
dti-1331	17	20	+	+	PROPN
dti-1331	17	21	.	.	PUNCT
dti-1331	18	1	nmda	nmda	ADJ
dti-1331	18	2	-	-	PUNCT
dti-1331	18	3	sensitive	sensitive	ADJ
dti-1331	18	4	ionotropic	ionotropic	ADJ
dti-1331	18	5	glutamate	glutamate	NOUN
dti-1331	18	6	receptors	receptor	NOUN
dti-1331	18	7	are	be	AUX
dti-1331	18	8	coupled	couple	VERB
dti-1331	18	9	to	to	ADP
dti-1331	18	10	high	high	ADJ
dti-1331	18	11	conductance	conductance	NOUN
dti-1331	18	12	cationic	cationic	ADJ
dti-1331	18	13	channels	channel	NOUN
dti-1331	18	14	permeable	permeable	ADJ
dti-1331	18	15	to	to	ADP
dti-1331	18	16	na+	na+	NOUN
dti-1331	18	17	,	,	PUNCT
dti-1331	18	18	k+	k+	NOUN
dti-1331	18	19	,	,	PUNCT
dti-1331	18	20	and	and	CCONJ
dti-1331	18	21	ca2	ca2	PROPN
dti-1331	18	22	+	+	PROPN
dti-1331	18	23	(	(	PUNCT
dti-1331	18	24	danysz	danysz	NOUN
dti-1331	18	25	et	et	PROPN
dti-1331	18	26	al	al	PROPN
dti-1331	18	27	.	.	PROPN
dti-1331	18	28	2000	2000	NUM
dti-1331	18	29	)	)	PUNCT
dti-1331	18	30	.	.	PUNCT
dti-1331	19	1	the	the	DET
dti-1331	19	2	nmda	nmda	ADJ
dti-1331	19	3	channel	channel	NOUN
dti-1331	19	4	is	be	AUX
dti-1331	19	5	blocked	block	VERB
dti-1331	19	6	in	in	ADP
dti-1331	19	7	a	a	DET
dti-1331	19	8	useand	useand	NOUN
dti-1331	19	9	voltage	voltage	NOUN
dti-1331	19	10	dependent	dependent	ADJ
dti-1331	19	11	manner	manner	NOUN
dti-1331	19	12	by	by	ADP
dti-1331	19	13	mg2	mg2	PROPN
dti-1331	19	14	+	+	PROPN
dti-1331	19	15	and	and	CCONJ
dti-1331	19	16	many	many	ADJ
dti-1331	19	17	exogenous	exogenous	ADJ
dti-1331	19	18	agents	agent	NOUN
dti-1331	19	19	.	.	PUNCT
dti-1331	20	1	nmda	nmda	ADJ
dti-1331	20	2	receptors	receptor	NOUN
dti-1331	20	3	are	be	AUX
dti-1331	20	4	only	only	ADV
dti-1331	20	5	activated	activate	VERB
dti-1331	20	6	following	follow	VERB
dti-1331	20	7	depolarisation	depolarisation	NOUN
dti-1331	20	8	of	of	ADP
dti-1331	20	9	the	the	DET
dti-1331	20	10	postsynaptic	postsynaptic	ADJ
dti-1331	20	11	membrane	membrane	NOUN
dti-1331	20	12	which	which	PRON
dti-1331	20	13	physiologically	physiologically	ADV
dti-1331	20	14	follows	follow	VERB
dti-1331	20	15	ampa	ampa	NOUN
dti-1331	20	16	receptor	receptor	NOUN
dti-1331	20	17	stimulation	stimulation	NOUN
dti-1331	20	18	which	which	PRON
dti-1331	20	19	relieves	relieve	VERB
dti-1331	20	20	blockade	blockade	NOUN
dti-1331	20	21	by	by	ADP
dti-1331	20	22	mg2	mg2	PROPN
dti-1331	20	23	+	+	PROPN
dti-1331	20	24	.	.	PUNCT
dti-1331	21	1	this	this	DET
dti-1331	21	2	unique	unique	ADJ
dti-1331	21	3	feature	feature	NOUN
dti-1331	21	4	and	and	CCONJ
dti-1331	21	5	the	the	DET
dti-1331	21	6	high	high	ADJ
dti-1331	21	7	ca2	ca2	PROPN
dti-1331	21	8	+	+	PROPN
dti-1331	21	9	permeability	permeability	NOUN
dti-1331	21	10	renders	render	VERB
dti-1331	21	11	nmda	nmda	ADJ
dti-1331	21	12	receptors	receptor	NOUN
dti-1331	21	13	inherently	inherently	ADV
dti-1331	21	14	suitable	suitable	ADJ
dti-1331	21	15	as	as	ADP
dti-1331	21	16	mediators	mediator	NOUN
dti-1331	21	17	of	of	ADP
dti-1331	21	18	synaptic	synaptic	ADJ
dti-1331	21	19	plasticity	plasticity	NOUN
dti-1331	21	20	(	(	PUNCT
dti-1331	21	21	e.g.	e.g.	ADV
dti-1331	21	22	learning	learn	VERB
dti-1331	21	23	and	and	CCONJ
dti-1331	21	24	memory	memory	NOUN
dti-1331	21	25	)	)	PUNCT
dti-1331	21	26	.	.	PUNCT
dti-1331	22	1	similar	similar	ADJ
dti-1331	22	2	to	to	ADP
dti-1331	22	3	mg2	mg2	PROPN
dti-1331	22	4	+	+	PROPN
dti-1331	22	5	,	,	PUNCT
dti-1331	22	6	uncompetitive	uncompetitive	ADJ
dti-1331	22	7	nmda	nmda	ADJ
dti-1331	22	8	receptor	receptor	NOUN
dti-1331	22	9	antagonists	antagonist	NOUN
dti-1331	22	10	such	such	ADJ
dti-1331	22	11	as	as	ADP
dti-1331	22	12	ketamine	ketamine	NOUN
dti-1331	22	13	,	,	PUNCT
dti-1331	22	14	dextromethorphan	dextromethorphan	PROPN
dti-1331	22	15	,	,	PUNCT
dti-1331	22	16	memantine	memantine	NOUN
dti-1331	22	17	,	,	PUNCT
dti-1331	22	18	phencyclidine	phencyclidine	NOUN
dti-1331	22	19	and	and	CCONJ
dti-1331	22	20	(	(	PUNCT
dti-1331	22	21	+	+	ADJ
dti-1331	22	22	)	)	PUNCT
dti-1331	22	23	-5	-5	ADJ
dti-1331	22	24	-	-	PUNCT
dti-1331	22	25	methyl-10,1l	methyl-10,1l	NOUN
dti-1331	22	26	-	-	PUNCT
dti-1331	22	27	dihydro-5hdibenzocyclohepten-5,10	dihydro-5hdibenzocyclohepten-5,10	NOUN
dti-1331	22	28	-	-	ADJ
dti-1331	22	29	imine	imine	ADJ
dti-1331	22	30	meleate	meleate	NOUN
dti-1331	22	31	(	(	PUNCT
dti-1331	22	32	+	+	ADJ
dti-1331	22	33	)	)	PUNCT
dti-1331	22	34	mk-801	mk-801	NOUN
dti-1331	22	35	block	block	VERB
dti-1331	22	36	the	the	DET
dti-1331	22	37	nmda	nmda	ADJ
dti-1331	22	38	channel	channel	NOUN
dti-1331	22	39	in	in	ADP
dti-1331	22	40	the	the	DET
dti-1331	22	41	open	open	ADJ
dti-1331	22	42	state	state	NOUN
dti-1331	22	43	,	,	PUNCT
dti-1331	22	44	although	although	SCONJ
dti-1331	22	45	the	the	DET
dti-1331	22	46	blocking	block	VERB
dti-1331	22	47	kinetics	kinetic	NOUN
dti-1331	22	48	and	and	CCONJ
dti-1331	22	49	voltage	voltage	NOUN
dti-1331	22	50	dependence	dependence	NOUN
dti-1331	22	51	of	of	ADP
dti-1331	22	52	this	this	DET
dti-1331	22	53	effect	effect	NOUN
dti-1331	22	54	vary	vary	VERB
dti-1331	22	55	considerably	considerably	ADV
dti-1331	22	56	(	(	PUNCT
dti-1331	22	57	danysz	danysz	NOUN
dti-1331	22	58	et	et	PROPN
dti-1331	22	59	al	al	PROPN
dti-1331	22	60	.	.	PROPN
dti-1331	22	61	2000	2000	NUM
dti-1331	22	62	)	)	PUNCT
dti-1331	22	63	.	.	PUNCT
dti-1331	23	1	glutamate	glutamate	VERB
dti-1331	23	2	and	and	CCONJ
dti-1331	23	3	nmda	nmda	ADJ
dti-1331	23	4	receptors	receptor	NOUN
dti-1331	23	5	are	be	AUX
dti-1331	23	6	involved	involve	VERB
dti-1331	23	7	in	in	ADP
dti-1331	23	8	long	long	ADJ
dti-1331	23	9	-	-	PUNCT
dti-1331	23	10	term	term	NOUN
dti-1331	23	11	potentiation	potentiation	NOUN
dti-1331	23	12	(	(	PUNCT
dti-1331	23	13	ltp	ltp	NOUN
dti-1331	23	14	)	)	PUNCT
dti-1331	23	15	,	,	PUNCT
dti-1331	23	16	a	a	DET
dti-1331	23	17	fundamental	fundamental	ADJ
dti-1331	23	18	process	process	NOUN
dti-1331	23	19	for	for	ADP
dti-1331	23	20	memory	memory	NOUN
dti-1331	23	21	consolidation	consolidation	NOUN
dti-1331	23	22	,	,	PUNCT
dti-1331	23	23	whereby	whereby	SCONJ
dti-1331	23	24	brief	brief	ADJ
dti-1331	23	25	high	high	ADJ
dti-1331	23	26	-	-	PUNCT
dti-1331	23	27	frequency	frequency	NOUN
dti-1331	23	28	stimulation	stimulation	NOUN
dti-1331	23	29	leads	lead	VERB
dti-1331	23	30	to	to	ADP
dti-1331	23	31	an	an	DET
dti-1331	23	32	increased	increase	VERB
dti-1331	23	33	response	response	NOUN
dti-1331	23	34	after	after	ADP
dti-1331	23	35	subsequent	subsequent	ADJ
dti-1331	23	36	activation	activation	NOUN
dti-1331	23	37	.	.	PUNCT
dti-1331	24	1	nmda	nmda	ADJ
dti-1331	24	2	receptors	receptor	NOUN
dti-1331	24	3	are	be	AUX
dti-1331	24	4	involved	involve	VERB
dti-1331	24	5	in	in	ADP
dti-1331	24	6	mediating	mediate	VERB
dti-1331	24	7	the	the	DET
dti-1331	24	8	postsynaptic	postsynaptic	ADJ
dti-1331	24	9	components	component	NOUN
dti-1331	24	10	of	of	ADP
dti-1331	24	11	ltp	ltp	PROPN
dti-1331	24	12	in	in	ADP
dti-1331	24	13	the	the	DET
dti-1331	24	14	hippocampus	hippocampus	NOUN
dti-1331	24	15	e.g.	e.g.	ADV
dti-1331	24	16	in	in	ADP
dti-1331	24	17	the	the	DET
dti-1331	24	18	schaffer	schaffer	PROPN
dti-1331	24	19	collateral	collateral	PROPN
dti-1331	24	20	projection	projection	NOUN
dti-1331	24	21	from	from	ADP
dti-1331	24	22	ca3	ca3	PROPN
dti-1331	24	23	to	to	ADP
dti-1331	24	24	ca1	ca1	PROPN
dti-1331	24	25	(	(	PUNCT
dti-1331	24	26	danysz	danysz	NOUN
dti-1331	24	27	et	et	PROPN
dti-1331	24	28	al	al	PROPN
dti-1331	24	29	.	.	PROPN
dti-1331	24	30	1995	1995	NUM
dti-1331	24	31	;	;	PUNCT
dti-1331	24	32	parsons	parson	NOUN
dti-1331	24	33	et	et	PROPN
dti-1331	24	34	al	al	PROPN
dti-1331	24	35	.	.	PROPN
dti-1331	24	36	1998	1998	NUM
dti-1331	24	37	;	;	PUNCT
dti-1331	24	38	fischer	fischer	PROPN
dti-1331	24	39	et	et	PROPN
dti-1331	24	40	al	al	PROPN
dti-1331	24	41	.	.	PROPN
dti-1331	24	42	1977	1977	NUM
dti-1331	24	43	)	)	PUNCT
dti-1331	24	44	.	.	PUNCT
dti-1331	25	1	under	under	ADP
dti-1331	25	2	normal	normal	ADJ
dti-1331	25	3	physiological	physiological	ADJ
dti-1331	25	4	resting	rest	VERB
dti-1331	25	5	conditions	condition	NOUN
dti-1331	25	6	,	,	PUNCT
dti-1331	25	7	the	the	DET
dti-1331	25	8	ion	ion	NOUN
dti-1331	25	9	channels	channel	NOUN
dti-1331	25	10	of	of	ADP
dti-1331	25	11	the	the	DET
dti-1331	25	12	nmda	nmda	ADJ
dti-1331	25	13	receptors	receptor	NOUN
dti-1331	25	14	are	be	AUX
dti-1331	25	15	blocked	block	VERB
dti-1331	25	16	by	by	ADP
dti-1331	25	17	magnesium	magnesium	NOUN
dti-1331	25	18	ions	ion	NOUN
dti-1331	25	19	in	in	ADP
dti-1331	25	20	a	a	DET
dti-1331	25	21	voltage	voltage	NOUN
dti-1331	25	22	-	-	PUNCT
dti-1331	25	23	dependent	dependent	ADJ
dti-1331	25	24	manner	manner	NOUN
dti-1331	25	25	.	.	PUNCT
dti-1331	26	1	the	the	DET
dti-1331	26	2	small	small	ADJ
dti-1331	26	3	amounts	amount	NOUN
dti-1331	26	4	of	of	ADP
dti-1331	26	5	glutamate	glutamate	NOUN
dti-1331	26	6	that	that	PRON
dti-1331	26	7	are	be	AUX
dti-1331	26	8	released	release	VERB
dti-1331	26	9	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1331	26	10	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	PROPN
dti-1331	26	11	78	78	NUM
dti-1331	26	12	moretti	moretti	PROPN
dti-1331	26	13	et	et	PROPN
dti-1331	26	14	al	al	PROPN
dti-1331	26	15	drug	drug	PROPN
dti-1331	26	16	target	target	NOUN
dti-1331	26	17	insights	insight	NOUN
dti-1331	26	18	2008:3	2008:3	NUM
dti-1331	26	19	are	be	AUX
dti-1331	26	20	not	not	PART
dti-1331	26	21	suffi	suffi	NOUN
dti-1331	26	22	cient	cient	NOUN
dti-1331	26	23	to	to	PART
dti-1331	26	24	displace	displace	VERB
dti-1331	26	25	the	the	DET
dti-1331	26	26	magnesium	magnesium	NOUN
dti-1331	26	27	ions	ion	NOUN
dti-1331	26	28	and	and	CCONJ
dti-1331	26	29	remove	remove	VERB
dti-1331	26	30	the	the	DET
dti-1331	26	31	blockade	blockade	NOUN
dti-1331	26	32	of	of	ADP
dti-1331	26	33	the	the	DET
dti-1331	26	34	nmda	nmda	ADJ
dti-1331	26	35	receptor	receptor	NOUN
dti-1331	26	36	channels	channel	NOUN
dti-1331	26	37	;	;	PUNCT
dti-1331	26	38	there	there	PRON
dti-1331	26	39	is	be	VERB
dti-1331	26	40	a	a	DET
dti-1331	26	41	so	so	ADV
dti-1331	26	42	-	-	PUNCT
dti-1331	26	43	called	call	VERB
dti-1331	26	44	“	"	PUNCT
dti-1331	26	45	low	low	ADJ
dti-1331	26	46	background	background	NOUN
dti-1331	26	47	noise	noise	NOUN
dti-1331	26	48	”	"	PUNCT
dti-1331	26	49	.	.	PUNCT
dti-1331	27	1	during	during	ADP
dti-1331	27	2	normal	normal	ADJ
dti-1331	27	3	synaptic	synaptic	ADJ
dti-1331	27	4	activity	activity	NOUN
dti-1331	27	5	,	,	PUNCT
dti-1331	27	6	larger	large	ADJ
dti-1331	27	7	concentrations	concentration	NOUN
dti-1331	27	8	of	of	ADP
dti-1331	27	9	glutamate	glutamate	NOUN
dti-1331	27	10	are	be	AUX
dti-1331	27	11	released	release	VERB
dti-1331	27	12	,	,	PUNCT
dti-1331	27	13	the	the	DET
dti-1331	27	14	postsynaptic	postsynaptic	ADJ
dti-1331	27	15	membrane	membrane	NOUN
dti-1331	27	16	is	be	AUX
dti-1331	27	17	depolarised	depolarise	VERB
dti-1331	27	18	,	,	PUNCT
dti-1331	27	19	the	the	DET
dti-1331	27	20	magnesium	magnesium	NOUN
dti-1331	27	21	blockade	blockade	NOUN
dti-1331	27	22	is	be	AUX
dti-1331	27	23	transiently	transiently	ADV
dti-1331	27	24	inactivated	inactivate	VERB
dti-1331	27	25	,	,	PUNCT
dti-1331	27	26	calcium	calcium	NOUN
dti-1331	27	27	ions	ion	NOUN
dti-1331	27	28	enter	enter	VERB
dti-1331	27	29	the	the	DET
dti-1331	27	30	cell	cell	NOUN
dti-1331	27	31	and	and	CCONJ
dti-1331	27	32	a	a	DET
dti-1331	27	33	signal	signal	NOUN
dti-1331	27	34	is	be	AUX
dti-1331	27	35	generated	generate	VERB
dti-1331	27	36	.	.	PUNCT
dti-1331	28	1	under	under	ADP
dti-1331	28	2	conditions	condition	NOUN
dti-1331	28	3	of	of	ADP
dti-1331	28	4	impaired	impaired	ADJ
dti-1331	28	5	metabolism	metabolism	NOUN
dti-1331	28	6	,	,	PUNCT
dti-1331	28	7	there	there	PRON
dti-1331	28	8	is	be	VERB
dti-1331	28	9	a	a	DET
dti-1331	28	10	sustained	sustained	ADJ
dti-1331	28	11	release	release	NOUN
dti-1331	28	12	of	of	ADP
dti-1331	28	13	glutamate	glutamate	NOUN
dti-1331	28	14	,	,	PUNCT
dti-1331	28	15	and	and	CCONJ
dti-1331	28	16	excessive	excessive	ADJ
dti-1331	28	17	glutamate	glutamate	NOUN
dti-1331	28	18	activity	activity	NOUN
dti-1331	28	19	is	be	AUX
dti-1331	28	20	associated	associate	VERB
dti-1331	28	21	with	with	ADP
dti-1331	28	22	excitotoxicity	excitotoxicity	NOUN
dti-1331	28	23	.	.	PUNCT
dti-1331	29	1	the	the	DET
dti-1331	29	2	magnesium	magnesium	NOUN
dti-1331	29	3	ions	ion	NOUN
dti-1331	29	4	are	be	AUX
dti-1331	29	5	lost	lose	VERB
dti-1331	29	6	from	from	ADP
dti-1331	29	7	the	the	DET
dti-1331	29	8	nmda	nmda	ADJ
dti-1331	29	9	receptors	receptor	NOUN
dti-1331	29	10	—	—	PUNCT
dti-1331	29	11	allowing	allow	VERB
dti-1331	29	12	a	a	DET
dti-1331	29	13	continuous	continuous	ADJ
dti-1331	29	14	infl	infl	PROPN
dti-1331	29	15	ux	ux	PROPN
dti-1331	29	16	of	of	ADP
dti-1331	29	17	calcium	calcium	NOUN
dti-1331	29	18	ions	ion	NOUN
dti-1331	29	19	into	into	ADP
dti-1331	29	20	the	the	DET
dti-1331	29	21	cell	cell	NOUN
dti-1331	29	22	-	-	PUNCT
dti-1331	29	23	creating	create	VERB
dti-1331	29	24	a	a	DET
dti-1331	29	25	high	high	ADJ
dti-1331	29	26	level	level	NOUN
dti-1331	29	27	of	of	ADP
dti-1331	29	28	background	background	NOUN
dti-1331	29	29	noise	noise	NOUN
dti-1331	29	30	and	and	CCONJ
dti-1331	29	31	impairing	impair	VERB
dti-1331	29	32	the	the	DET
dti-1331	29	33	recognition	recognition	NOUN
dti-1331	29	34	of	of	ADP
dti-1331	29	35	signals	signal	NOUN
dti-1331	29	36	,	,	PUNCT
dti-1331	29	37	resulting	result	VERB
dti-1331	29	38	from	from	ADP
dti-1331	29	39	physiological	physiological	ADJ
dti-1331	29	40	activation	activation	NOUN
dti-1331	29	41	of	of	ADP
dti-1331	29	42	the	the	DET
dti-1331	29	43	receptor	receptor	NOUN
dti-1331	29	44	.	.	PUNCT
dti-1331	30	1	high	high	ADJ
dti-1331	30	2	intracellular	intracellular	ADJ
dti-1331	30	3	concentrations	concentration	NOUN
dti-1331	30	4	of	of	ADP
dti-1331	30	5	calcium	calcium	NOUN
dti-1331	30	6	eventually	eventually	ADV
dti-1331	30	7	lead	lead	VERB
dti-1331	30	8	to	to	ADP
dti-1331	30	9	neuronal	neuronal	ADJ
dti-1331	30	10	degeneration	degeneration	NOUN
dti-1331	30	11	and	and	CCONJ
dti-1331	30	12	cell	cell	NOUN
dti-1331	30	13	death	death	NOUN
dti-1331	30	14	.	.	PUNCT
dti-1331	31	1	memantine	memantine	NOUN
dti-1331	31	2	blocks	block	NOUN
dti-1331	31	3	nmda	nmda	ADJ
dti-1331	31	4	receptor	receptor	NOUN
dti-1331	31	5	channels	channel	NOUN
dti-1331	31	6	in	in	ADP
dti-1331	31	7	cultured	cultured	ADJ
dti-1331	31	8	neurons	neuron	NOUN
dti-1331	31	9	in	in	ADP
dti-1331	31	10	a	a	DET
dti-1331	31	11	voltage	voltage	NOUN
dti-1331	31	12	-	-	PUNCT
dti-1331	31	13	dependent	dependent	ADJ
dti-1331	31	14	manner	manner	NOUN
dti-1331	31	15	as	as	SCONJ
dti-1331	31	16	measured	measure	VERB
dti-1331	31	17	by	by	ADP
dti-1331	31	18	patch	patch	NOUN
dti-1331	31	19	clamp	clamp	NOUN
dti-1331	31	20	technique	technique	NOUN
dti-1331	31	21	(	(	PUNCT
dti-1331	31	22	chen	chen	PROPN
dti-1331	31	23	et	et	PROPN
dti-1331	31	24	al	al	PROPN
dti-1331	31	25	.	.	PROPN
dti-1331	31	26	1997	1997	NUM
dti-1331	31	27	;	;	PUNCT
dti-1331	31	28	blanpied	blanpie	VERB
dti-1331	31	29	et	et	PROPN
dti-1331	31	30	al	al	PROPN
dti-1331	31	31	.	.	PROPN
dti-1331	31	32	1997	1997	NUM
dti-1331	31	33	;	;	PUNCT
dti-1331	31	34	borman	borman	NOUN
dti-1331	31	35	et	et	PROPN
dti-1331	31	36	al	al	PROPN
dti-1331	31	37	.	.	PROPN
dti-1331	31	38	1989	1989	NUM
dti-1331	31	39	)	)	PUNCT
dti-1331	31	40	.	.	PUNCT
dti-1331	32	1	the	the	DET
dti-1331	32	2	effects	effect	NOUN
dti-1331	32	3	of	of	ADP
dti-1331	32	4	memantine	memantine	NOUN
dti-1331	32	5	were	be	AUX
dti-1331	32	6	not	not	PART
dti-1331	32	7	reversed	reverse	VERB
dti-1331	32	8	by	by	ADP
dti-1331	32	9	exposure	exposure	NOUN
dti-1331	32	10	to	to	ADP
dti-1331	32	11	glycine	glycine	NOUN
dti-1331	32	12	�	�	PROPN
dti-1331	32	13	100	100	NUM
dti-1331	32	14	micromol	micromol	PROPN
dti-1331	32	15	/	/	SYM
dti-1331	32	16	l	l	NOUN
dti-1331	32	17	(	(	PUNCT
dti-1331	32	18	borman	borman	NOUN
dti-1331	32	19	et	et	PROPN
dti-1331	32	20	al	al	PROPN
dti-1331	32	21	.	.	PROPN
dti-1331	32	22	1989	1989	NUM
dti-1331	32	23	)	)	PUNCT
dti-1331	32	24	.	.	PUNCT
dti-1331	33	1	memantine	memantine	NOUN
dti-1331	33	2	induces	induce	VERB
dti-1331	33	3	open	open	ADJ
dti-1331	33	4	-	-	PUNCT
dti-1331	33	5	channel	channel	NOUN
dti-1331	33	6	blockade	blockade	NOUN
dti-1331	33	7	of	of	ADP
dti-1331	33	8	nmda	nmda	ADJ
dti-1331	33	9	receptors	receptor	NOUN
dti-1331	33	10	(	(	PUNCT
dti-1331	33	11	ambrozi	ambrozi	NOUN
dti-1331	33	12	et	et	PROPN
dti-1331	33	13	al	al	PROPN
dti-1331	33	14	.	.	PROPN
dti-1331	33	15	1988	1988	NUM
dti-1331	33	16	)	)	PUNCT
dti-1331	33	17	and	and	CCONJ
dti-1331	33	18	is	be	AUX
dti-1331	33	19	‘	'	PUNCT
dti-1331	33	20	partially	partially	ADV
dti-1331	33	21	trapped	trap	VERB
dti-1331	33	22	’	'	PUNCT
dti-1331	33	23	in	in	ADP
dti-1331	33	24	nmda	nmda	ADJ
dti-1331	33	25	receptor	receptor	NOUN
dti-1331	33	26	channels	channel	NOUN
dti-1331	33	27	(	(	PUNCT
dti-1331	33	28	chen	chen	PROPN
dti-1331	33	29	et	et	PROPN
dti-1331	33	30	al	al	PROPN
dti-1331	33	31	.	.	PROPN
dti-1331	33	32	1999	1999	NUM
dti-1331	33	33	;	;	PUNCT
dti-1331	33	34	frankiewicz	frankiewicz	VERB
dti-1331	33	35	et	et	PROPN
dti-1331	33	36	al	al	PROPN
dti-1331	33	37	.	.	PROPN
dti-1331	33	38	1999	1999	NUM
dti-1331	33	39	)	)	PUNCT
dti-1331	33	40	.	.	PUNCT
dti-1331	34	1	memantine	memantine	NOUN
dti-1331	34	2	could	could	AUX
dti-1331	34	3	be	be	AUX
dti-1331	34	4	washed	wash	VERB
dti-1331	34	5	from	from	ADP
dti-1331	34	6	approximately	approximately	ADV
dti-1331	34	7	one	one	NUM
dti-1331	34	8	-	-	PUNCT
dti-1331	34	9	sixth	sixth	NOUN
dti-1331	34	10	of	of	ADP
dti-1331	34	11	channels	channel	NOUN
dti-1331	34	12	during	during	ADP
dti-1331	34	13	in	in	ADP
dti-1331	34	14	vitro	vitro	X
dti-1331	34	15	experiments	experiment	NOUN
dti-1331	34	16	(	(	PUNCT
dti-1331	34	17	frankiewicz	frankiewicz	VERB
dti-1331	34	18	et	et	PROPN
dti-1331	34	19	al	al	PROPN
dti-1331	34	20	.	.	PROPN
dti-1331	34	21	1999	1999	NUM
dti-1331	34	22	)	)	PUNCT
dti-1331	34	23	.	.	PUNCT
dti-1331	35	1	memantine	memantine	NOUN
dti-1331	35	2	protects	protect	VERB
dti-1331	35	3	cultured	cultured	ADJ
dti-1331	35	4	neurons	neuron	NOUN
dti-1331	35	5	from	from	ADP
dti-1331	35	6	excitotoxin	excitotoxin	PROPN
dti-1331	35	7	-	-	PUNCT
dti-1331	35	8	induced	induce	VERB
dti-1331	35	9	cell	cell	NOUN
dti-1331	35	10	death	death	NOUN
dti-1331	35	11	(	(	PUNCT
dti-1331	35	12	parsons	parson	NOUN
dti-1331	35	13	et	et	PROPN
dti-1331	35	14	al	al	PROPN
dti-1331	35	15	.	.	PROPN
dti-1331	35	16	1993	1993	NUM
dti-1331	35	17	;	;	PUNCT
dti-1331	35	18	krieglstein	krieglstein	PROPN
dti-1331	35	19	et	et	PROPN
dti-1331	35	20	al	al	PROPN
dti-1331	35	21	.	.	PROPN
dti-1331	35	22	1996	1996	NUM
dti-1331	35	23	;	;	PUNCT
dti-1331	35	24	erdo	erdo	NOUN
dti-1331	35	25	et	et	PROPN
dti-1331	35	26	al	al	PROPN
dti-1331	35	27	.	.	PROPN
dti-1331	35	28	1991	1991	NUM
dti-1331	35	29	;	;	PUNCT
dti-1331	35	30	weller	weller	PROPN
dti-1331	35	31	et	et	PROPN
dti-1331	35	32	al	al	PROPN
dti-1331	35	33	.	.	PROPN
dti-1331	35	34	1993	1993	NUM
dti-1331	35	35	;	;	PUNCT
dti-1331	35	36	pellegrini	pellegrini	PROPN
dti-1331	35	37	et	et	PROPN
dti-1331	35	38	al	al	PROPN
dti-1331	35	39	.	.	PROPN
dti-1331	35	40	1993	1993	NUM
dti-1331	35	41	)	)	PUNCT
dti-1331	35	42	.	.	PUNCT
dti-1331	36	1	memantine	memantine	PROPN
dti-1331	36	2	exerts	exert	VERB
dti-1331	36	3	neuroprotective	neuroprotective	ADJ
dti-1331	36	4	effects	effect	NOUN
dti-1331	36	5	in	in	ADP
dti-1331	36	6	several	several	ADJ
dti-1331	36	7	models	model	NOUN
dti-1331	36	8	of	of	ADP
dti-1331	36	9	brain	brain	NOUN
dti-1331	36	10	injury	injury	NOUN
dti-1331	36	11	.	.	PUNCT
dti-1331	37	1	the	the	DET
dti-1331	37	2	drug	drug	NOUN
dti-1331	37	3	attenuated	attenuate	VERB
dti-1331	37	4	loss	loss	NOUN
dti-1331	37	5	of	of	ADP
dti-1331	37	6	cholinergic	cholinergic	ADJ
dti-1331	37	7	neurons	neuron	NOUN
dti-1331	37	8	in	in	ADP
dti-1331	37	9	the	the	DET
dti-1331	37	10	cns	cns	NOUN
dti-1331	37	11	induced	induce	VERB
dti-1331	37	12	by	by	ADP
dti-1331	37	13	injection	injection	NOUN
dti-1331	37	14	of	of	ADP
dti-1331	37	15	nmda	nmda	NOUN
dti-1331	37	16	into	into	ADP
dti-1331	37	17	the	the	DET
dti-1331	37	18	basal	basal	ADJ
dti-1331	37	19	forebrain	forebrain	NOUN
dti-1331	37	20	of	of	ADP
dti-1331	37	21	rats	rat	NOUN
dti-1331	37	22	(	(	PUNCT
dti-1331	37	23	wenk	wenk	PROPN
dti-1331	37	24	et	et	PROPN
dti-1331	37	25	al	al	PROPN
dti-1331	37	26	.	.	PROPN
dti-1331	37	27	1997	1997	NUM
dti-1331	37	28	)	)	PUNCT
dti-1331	37	29	.	.	PUNCT
dti-1331	38	1	memantine	memantine	PROPN
dti-1331	38	2	also	also	ADV
dti-1331	38	3	attenuated	attenuate	VERB
dti-1331	38	4	neuronal	neuronal	ADJ
dti-1331	38	5	injury	injury	NOUN
dti-1331	38	6	in	in	ADP
dti-1331	38	7	various	various	ADJ
dti-1331	38	8	rat	rat	NOUN
dti-1331	38	9	models	model	NOUN
dti-1331	38	10	including	include	VERB
dti-1331	38	11	traumatic	traumatic	ADJ
dti-1331	38	12	brain	brain	NOUN
dti-1331	38	13	injury	injury	NOUN
dti-1331	38	14	(	(	PUNCT
dti-1331	38	15	rao	rao	NOUN
dti-1331	38	16	et	et	PROPN
dti-1331	38	17	al	al	PROPN
dti-1331	38	18	.	.	PROPN
dti-1331	38	19	2001	2001	NUM
dti-1331	38	20	)	)	PUNCT
dti-1331	38	21	,	,	PUNCT
dti-1331	38	22	ischaemic	ischaemic	ADJ
dti-1331	38	23	stroke	stroke	NOUN
dti-1331	38	24	induced	induce	VERB
dti-1331	38	25	by	by	ADP
dti-1331	38	26	occlusion	occlusion	NOUN
dti-1331	38	27	of	of	ADP
dti-1331	38	28	cerebral	cerebral	ADJ
dti-1331	38	29	(	(	PUNCT
dti-1331	38	30	gorgiilii	gorgiilii	NOUN
dti-1331	38	31	et	et	PROPN
dti-1331	38	32	al	al	PROPN
dti-1331	38	33	.	.	PROPN
dti-1331	38	34	2000	2000	NUM
dti-1331	38	35	;	;	PUNCT
dti-1331	39	1	dogan	dogan	PROPN
dti-1331	39	2	et	et	PROPN
dti-1331	39	3	al	al	PROPN
dti-1331	39	4	.	.	PROPN
dti-1331	39	5	1999	1999	NUM
dti-1331	39	6	)	)	PUNCT
dti-1331	39	7	or	or	CCONJ
dti-1331	39	8	carotid	carotid	NOUN
dti-1331	39	9	arteries	artery	NOUN
dti-1331	39	10	(	(	PUNCT
dti-1331	39	11	seif	seif	PROPN
dti-1331	39	12	ej	ej	PROPN
dti-1331	39	13	nasi	nasi	PROPN
dti-1331	39	14	’	'	PUNCT
dti-1331	39	15	et	et	PROPN
dti-1331	39	16	al	al	PROPN
dti-1331	39	17	.	.	PROPN
dti-1331	39	18	1990	1990	NUM
dti-1331	39	19	;	;	PUNCT
dti-1331	39	20	heim	heim	PROPN
dti-1331	39	21	et	et	PROPN
dti-1331	39	22	al	al	PROPN
dti-1331	39	23	.	.	PROPN
dti-1331	39	24	1995	1995	NUM
dti-1331	39	25	)	)	PUNCT
dti-1331	39	26	,	,	PUNCT
dti-1331	39	27	a	a	DET
dti-1331	39	28	photo	photo	NOUN
dti-1331	39	29	-	-	PUNCT
dti-1331	39	30	induced	induce	VERB
dti-1331	39	31	thrombotic	thrombotic	ADJ
dti-1331	39	32	model	model	NOUN
dti-1331	39	33	of	of	ADP
dti-1331	39	34	cerebral	cerebral	ADJ
dti-1331	39	35	focal	focal	ADJ
dti-1331	39	36	ischaemia	ischaemia	NOUN
dti-1331	39	37	(	(	PUNCT
dti-1331	39	38	stieg	stieg	PROPN
dti-1331	39	39	et	et	PROPN
dti-1331	39	40	al	al	PROPN
dti-1331	39	41	.	.	PROPN
dti-1331	39	42	1999	1999	NUM
dti-1331	39	43	)	)	PUNCT
dti-1331	39	44	and	and	CCONJ
dti-1331	39	45	quinolinic	quinolinic	ADJ
dti-1331	39	46	acid	acid	NOUN
dti-1331	39	47	-	-	PUNCT
dti-1331	39	48	induced	induce	VERB
dti-1331	39	49	hippocampal	hippocampal	ADJ
dti-1331	39	50	damage	damage	NOUN
dti-1331	39	51	(	(	PUNCT
dti-1331	39	52	keilhoff	keilhoff	NOUN
dti-1331	39	53	et	et	PROPN
dti-1331	39	54	al	al	PROPN
dti-1331	39	55	.	.	PROPN
dti-1331	39	56	1992	1992	NUM
dti-1331	39	57	)	)	PUNCT
dti-1331	39	58	.	.	PUNCT
dti-1331	40	1	at	at	ADP
dti-1331	40	2	a	a	DET
dti-1331	40	3	dosage	dosage	NOUN
dti-1331	40	4	of	of	ADP
dti-1331	40	5	5–50	5–50	NOUN
dti-1331	40	6	mg	mg	PROPN
dti-1331	40	7	/	/	SYM
dti-1331	40	8	kg	kg	PROPN
dti-1331	40	9	in	in	ADP
dti-1331	40	10	rats	rat	NOUN
dti-1331	40	11	,	,	PUNCT
dti-1331	40	12	memantine	memantine	ADJ
dti-1331	40	13	induced	induce	VERB
dti-1331	40	14	production	production	NOUN
dti-1331	40	15	of	of	ADP
dti-1331	40	16	brain	brain	NOUN
dti-1331	40	17	-	-	PUNCT
dti-1331	40	18	derived	derive	VERB
dti-1331	40	19	neurotrophic	neurotrophic	ADJ
dti-1331	40	20	factor	factor	NOUN
dti-1331	40	21	(	(	PUNCT
dti-1331	40	22	bdnf	bdnf	PROPN
dti-1331	40	23	)	)	PUNCT
dti-1331	40	24	,	,	PUNCT
dti-1331	40	25	a	a	DET
dti-1331	40	26	substance	substance	NOUN
dti-1331	40	27	shown	show	VERB
dti-1331	40	28	to	to	PART
dti-1331	40	29	promote	promote	VERB
dti-1331	40	30	survival	survival	NOUN
dti-1331	40	31	and	and	CCONJ
dti-1331	40	32	differentiation	differentiation	NOUN
dti-1331	40	33	of	of	ADP
dti-1331	40	34	cns	cns	NOUN
dti-1331	40	35	neurons	neuron	NOUN
dti-1331	40	36	,	,	PUNCT
dti-1331	40	37	and	and	CCONJ
dti-1331	40	38	trkb	trkb	NOUN
dti-1331	40	39	,	,	PUNCT
dti-1331	40	40	a	a	DET
dti-1331	40	41	tyrosine	tyrosine	NOUN
dti-1331	40	42	kinase	kinase	NOUN
dti-1331	40	43	receptor	receptor	NOUN
dti-1331	40	44	for	for	ADP
dti-1331	40	45	bdnf	bdnf	PROPN
dti-1331	40	46	(	(	PUNCT
dti-1331	40	47	keilhoff	keilhoff	NOUN
dti-1331	40	48	et	et	PROPN
dti-1331	40	49	al	al	PROPN
dti-1331	40	50	.	.	PROPN
dti-1331	40	51	1992	1992	NUM
dti-1331	40	52	)	)	PUNCT
dti-1331	40	53	.	.	PUNCT
dti-1331	41	1	mrna	mrna	PROPN
dti-1331	41	2	for	for	ADP
dti-1331	41	3	bdnf	bdnf	PROPN
dti-1331	41	4	and	and	CCONJ
dti-1331	41	5	trkb	trkb	NOUN
dti-1331	41	6	was	be	AUX
dti-1331	41	7	detected	detect	VERB
dti-1331	41	8	in	in	ADP
dti-1331	41	9	limbic	limbic	ADJ
dti-1331	41	10	cortex	cortex	NOUN
dti-1331	41	11	slices	slice	NOUN
dti-1331	41	12	by	by	ADP
dti-1331	41	13	in	in	ADP
dti-1331	41	14	situ	situ	ADJ
dti-1331	41	15	hybridisation	hybridisation	NOUN
dti-1331	41	16	(	(	PUNCT
dti-1331	41	17	lundbeck	lundbeck	PROPN
dti-1331	41	18	ais	ais	PROPN
dti-1331	41	19	,	,	PUNCT
dti-1331	41	20	2002	2002	NUM
dti-1331	41	21	)	)	PUNCT
dti-1331	41	22	.	.	PUNCT
dti-1331	42	1	clinical	clinical	ADJ
dti-1331	42	2	therapy	therapy	NOUN
dti-1331	42	3	due	due	ADP
dti-1331	42	4	to	to	ADP
dti-1331	42	5	its	its	PRON
dti-1331	42	6	preclinical	preclinical	ADJ
dti-1331	42	7	effects	effect	NOUN
dti-1331	42	8	,	,	PUNCT
dti-1331	42	9	above	above	ADP
dti-1331	42	10	described	describe	VERB
dti-1331	42	11	,	,	PUNCT
dti-1331	42	12	memantine	memantine	NOUN
dti-1331	42	13	,	,	PUNCT
dti-1331	42	14	late	late	ADV
dti-1331	42	15	in	in	ADP
dti-1331	42	16	2003	2003	NUM
dti-1331	42	17	,	,	PUNCT
dti-1331	42	18	was	be	AUX
dti-1331	42	19	approved	approve	VERB
dti-1331	42	20	by	by	ADP
dti-1331	42	21	the	the	DET
dti-1331	42	22	fda	fda	PROPN
dti-1331	42	23	as	as	ADP
dti-1331	42	24	a	a	DET
dti-1331	42	25	drug	drug	NOUN
dti-1331	42	26	for	for	ADP
dti-1331	42	27	ad	ad	NOUN
dti-1331	42	28	treatment	treatment	NOUN
dti-1331	42	29	.	.	PUNCT
dti-1331	43	1	memantine	memantine	NOUN
dti-1331	43	2	is	be	AUX
dti-1331	43	3	indicated	indicate	VERB
dti-1331	43	4	for	for	ADP
dti-1331	43	5	the	the	DET
dti-1331	43	6	treatment	treatment	NOUN
dti-1331	43	7	of	of	ADP
dti-1331	43	8	moderate	moderate	ADJ
dti-1331	43	9	to	to	ADP
dti-1331	43	10	severe	severe	ADJ
dti-1331	43	11	alzheimer	alzheimer	PROPN
dti-1331	43	12	’s	’s	PART
dti-1331	43	13	disease	disease	NOUN
dti-1331	43	14	,	,	PUNCT
dti-1331	43	15	refl	refl	PROPN
dti-1331	43	16	ecting	ecte	VERB
dti-1331	43	17	a	a	DET
dti-1331	43	18	license	license	NOUN
dti-1331	43	19	extension	extension	NOUN
dti-1331	43	20	granted	grant	VERB
dti-1331	43	21	by	by	ADP
dti-1331	43	22	the	the	DET
dti-1331	43	23	european	european	PROPN
dti-1331	43	24	commission	commission	PROPN
dti-1331	43	25	in	in	ADP
dti-1331	43	26	october	october	PROPN
dti-1331	43	27	2005	2005	NUM
dti-1331	43	28	to	to	PART
dti-1331	43	29	include	include	VERB
dti-1331	43	30	the	the	DET
dti-1331	43	31	moderate	moderate	ADJ
dti-1331	43	32	ad	ad	NOUN
dti-1331	43	33	patient	patient	NOUN
dti-1331	43	34	population	population	NOUN
dti-1331	43	35	.	.	PUNCT
dti-1331	44	1	post	post	ADJ
dti-1331	44	2	-	-	ADJ
dti-1331	44	3	mortem	mortem	ADJ
dti-1331	44	4	orepidemiological	orepidemiological	ADJ
dti-1331	44	5	studies	study	NOUN
dti-1331	44	6	suggest	suggest	VERB
dti-1331	44	7	a	a	DET
dti-1331	44	8	strong	strong	ADJ
dti-1331	44	9	association	association	NOUN
dti-1331	44	10	between	between	ADP
dti-1331	44	11	glutamate	glutamate	ADJ
dti-1331	44	12	dysfunction	dysfunction	NOUN
dti-1331	44	13	and	and	CCONJ
dti-1331	44	14	alzheimer	alzheimer	PROPN
dti-1331	44	15	’s	’s	PART
dti-1331	44	16	disease	disease	NOUN
dti-1331	44	17	.	.	PUNCT
dti-1331	45	1	some	some	DET
dti-1331	45	2	authors	author	NOUN
dti-1331	45	3	observed	observe	VERB
dti-1331	45	4	co	co	NOUN
dti-1331	45	5	-	-	NOUN
dti-1331	45	6	localisation	localisation	NOUN
dti-1331	45	7	of	of	ADP
dti-1331	45	8	glutamatergic	glutamatergic	ADJ
dti-1331	45	9	neurones	neurone	NOUN
dti-1331	45	10	and	and	CCONJ
dti-1331	45	11	pathological	pathological	ADJ
dti-1331	45	12	alterations	alteration	NOUN
dti-1331	45	13	(	(	PUNCT
dti-1331	45	14	neurofi	neurofi	ADV
dti-1331	45	15	brillary	brillary	ADJ
dti-1331	45	16	tangles	tangle	NOUN
dti-1331	45	17	and	and	CCONJ
dti-1331	45	18	senile	senile	ADJ
dti-1331	45	19	plaques	plaque	NOUN
dti-1331	45	20	)	)	PUNCT
dti-1331	45	21	in	in	ADP
dti-1331	45	22	post	post	ADJ
dti-1331	45	23	-	-	ADJ
dti-1331	45	24	mortem	mortem	ADJ
dti-1331	45	25	analysis	analysis	NOUN
dti-1331	45	26	of	of	ADP
dti-1331	45	27	the	the	DET
dti-1331	45	28	brains	brain	NOUN
dti-1331	45	29	of	of	ADP
dti-1331	45	30	alzheimer	alzheimer	PROPN
dti-1331	45	31	’s	’s	PART
dti-1331	45	32	patients	patient	NOUN
dti-1331	45	33	(	(	PUNCT
dti-1331	45	34	braak	braak	NOUN
dti-1331	45	35	et	et	PROPN
dti-1331	45	36	al	al	PROPN
dti-1331	45	37	.	.	PROPN
dti-1331	45	38	1993	1993	NUM
dti-1331	45	39	;	;	PUNCT
dti-1331	45	40	francis	francis	PROPN
dti-1331	45	41	et	et	PROPN
dti-1331	45	42	al	al	PROPN
dti-1331	45	43	.	.	PROPN
dti-1331	45	44	1993	1993	NUM
dti-1331	45	45	)	)	PUNCT
dti-1331	45	46	.	.	PUNCT
dti-1331	46	1	in	in	ADP
dti-1331	46	2	alzheimer	alzheimer	PROPN
dti-1331	46	3	's	's	PART
dti-1331	46	4	disease	disease	NOUN
dti-1331	46	5	there	there	PRON
dti-1331	46	6	is	be	VERB
dti-1331	46	7	an	an	DET
dti-1331	46	8	increase	increase	NOUN
dti-1331	46	9	of	of	ADP
dti-1331	46	10	glutamate	glutamate	NOUN
dti-1331	46	11	,	,	PUNCT
dti-1331	46	12	caused	cause	VERB
dti-1331	46	13	by	by	ADP
dti-1331	46	14	a	a	DET
dti-1331	46	15	decrease	decrease	NOUN
dti-1331	46	16	of	of	ADP
dti-1331	46	17	uptake	uptake	NOUN
dti-1331	46	18	and/or	and/or	CCONJ
dti-1331	46	19	increase	increase	NOUN
dti-1331	46	20	of	of	ADP
dti-1331	46	21	release	release	NOUN
dti-1331	46	22	.	.	PUNCT
dti-1331	47	1	there	there	PRON
dti-1331	47	2	is	be	VERB
dti-1331	47	3	a	a	DET
dti-1331	47	4	decrease	decrease	NOUN
dti-1331	47	5	in	in	ADP
dti-1331	47	6	astroglial	astroglial	ADJ
dti-1331	47	7	glutamate	glutamate	ADJ
dti-1331	47	8	carrier	carrier	NOUN
dti-1331	47	9	eaa2	eaa2	PROPN
dti-1331	47	10	in	in	ADP
dti-1331	47	11	the	the	DET
dti-1331	47	12	frontal	frontal	ADJ
dti-1331	47	13	cortex	cortex	NOUN
dti-1331	47	14	of	of	ADP
dti-1331	47	15	post	post	ADJ
dti-1331	47	16	-	-	ADJ
dti-1331	47	17	mortem	mortem	ADJ
dti-1331	47	18	samples	sample	NOUN
dti-1331	47	19	from	from	ADP
dti-1331	47	20	brains	brain	NOUN
dti-1331	47	21	of	of	ADP
dti-1331	47	22	alzheimer	alzheimer	PROPN
dti-1331	47	23	’s	’s	PART
dti-1331	47	24	patients	patient	NOUN
dti-1331	47	25	(	(	PUNCT
dti-1331	47	26	li	li	PROPN
dti-1331	47	27	et	et	PROPN
dti-1331	47	28	al	al	PROPN
dti-1331	47	29	.	.	PROPN
dti-1331	47	30	1997	1997	NUM
dti-1331	47	31	)	)	PUNCT
dti-1331	47	32	.	.	PUNCT
dti-1331	48	1	in	in	ADP
dti-1331	48	2	vitro	vitro	X
dti-1331	48	3	constituents	constituent	NOUN
dti-1331	48	4	of	of	ADP
dti-1331	48	5	senile	senile	ADJ
dti-1331	48	6	plaques	plaque	NOUN
dti-1331	48	7	stimulate	stimulate	VERB
dti-1331	48	8	microglia	microglia	NOUN
dti-1331	48	9	to	to	PART
dti-1331	48	10	produce	produce	VERB
dti-1331	48	11	an	an	DET
dti-1331	48	12	unknown	unknown	ADJ
dti-1331	48	13	neurotoxin	neurotoxin	NOUN
dti-1331	48	14	having	have	VERB
dti-1331	48	15	agonistic	agonistic	ADJ
dti-1331	48	16	properties	property	NOUN
dti-1331	48	17	at	at	ADP
dti-1331	48	18	nmda	nmda	ADJ
dti-1331	48	19	receptors	receptor	NOUN
dti-1331	48	20	(	(	PUNCT
dti-1331	48	21	giulian	giulian	NOUN
dti-1331	48	22	et	et	PROPN
dti-1331	48	23	al	al	PROPN
dti-1331	48	24	.	.	PROPN
dti-1331	48	25	1995	1995	NUM
dti-1331	48	26	;	;	PUNCT
dti-1331	48	27	klegeris	klegeris	PROPN
dti-1331	48	28	et	et	PROPN
dti-1331	48	29	al	al	PROPN
dti-1331	48	30	.	.	PROPN
dti-1331	48	31	1997	1997	NUM
dti-1331	48	32	)	)	PUNCT
dti-1331	48	33	.	.	PUNCT
dti-1331	49	1	beta	beta	NOUN
dti-1331	49	2	-	-	PUNCT
dti-1331	49	3	amyloid	amyloid	NOUN
dti-1331	49	4	peptide	peptide	NOUN
dti-1331	49	5	either	either	CCONJ
dti-1331	49	6	activates	activate	VERB
dti-1331	49	7	nmda	nmda	ADJ
dti-1331	49	8	receptors	receptor	NOUN
dti-1331	49	9	or	or	CCONJ
dti-1331	49	10	enhances	enhance	VERB
dti-1331	49	11	their	their	PRON
dti-1331	49	12	sensitivity	sensitivity	NOUN
dti-1331	49	13	(	(	PUNCT
dti-1331	49	14	goodwin	goodwin	PROPN
dti-1331	49	15	et	et	PROPN
dti-1331	49	16	al	al	PROPN
dti-1331	49	17	.	.	PROPN
dti-1331	49	18	1995	1995	NUM
dti-1331	49	19	)	)	PUNCT
dti-1331	49	20	;	;	PUNCT
dti-1331	49	21	in	in	ADP
dti-1331	49	22	fact	fact	NOUN
dti-1331	49	23	,	,	PUNCT
dti-1331	49	24	beta	beta	NOUN
dti-1331	49	25	-	-	PUNCT
dti-1331	49	26	amyloid	amyloid	NOUN
dti-1331	49	27	(	(	PUNCT
dti-1331	49	28	1–40	1–40	NUM
dti-1331	49	29	)	)	PUNCT
dti-1331	49	30	stimulates	stimulate	VERB
dti-1331	49	31	nitric	nitric	ADJ
dti-1331	49	32	oxid	oxid	NOUN
dti-1331	49	33	(	(	PUNCT
dti-1331	49	34	no	no	NOUN
dti-1331	49	35	)	)	PUNCT
dti-1331	49	36	production	production	NOUN
dti-1331	49	37	by	by	ADP
dti-1331	49	38	microglia	microglia	NOUN
dti-1331	49	39	(	(	PUNCT
dti-1331	49	40	goodwin	goodwin	PROPN
dti-1331	49	41	et	et	PROPN
dti-1331	49	42	al	al	PROPN
dti-1331	49	43	.	.	PROPN
dti-1331	50	1	1995)—no	1995)—no	PROPN
dti-1331	50	2	is	be	AUX
dti-1331	50	3	known	know	VERB
dti-1331	50	4	to	to	PART
dti-1331	50	5	enhance	enhance	VERB
dti-1331	50	6	glutamate	glutamate	ADJ
dti-1331	50	7	release	release	NOUN
dti-1331	50	8	and	and	CCONJ
dti-1331	50	9	to	to	PART
dti-1331	50	10	inhibit	inhibit	VERB
dti-1331	50	11	uptake	uptake	ADJ
dti-1331	50	12	(	(	PUNCT
dti-1331	50	13	brorson	brorson	NOUN
dti-1331	50	14	et	et	PROPN
dti-1331	50	15	al	al	PROPN
dti-1331	50	16	.	.	PROPN
dti-1331	50	17	1995	1995	NUM
dti-1331	50	18	)	)	PUNCT
dti-1331	50	19	.	.	PUNCT
dti-1331	51	1	beta	beta	NOUN
dti-1331	51	2	-	-	PUNCT
dti-1331	51	3	amyloid	amyloid	NOUN
dti-1331	51	4	peptide	peptide	NOUN
dti-1331	51	5	enhances	enhance	VERB
dti-1331	51	6	the	the	DET
dti-1331	51	7	toxicity	toxicity	NOUN
dti-1331	51	8	of	of	ADP
dti-1331	51	9	glutamate	glutamate	NOUN
dti-1331	51	10	in	in	ADP
dti-1331	51	11	in	in	ADP
dti-1331	51	12	vitro	vitro	X
dti-1331	51	13	test	test	NOUN
dti-1331	51	14	(	(	PUNCT
dti-1331	51	15	mattson	mattson	PROPN
dti-1331	51	16	et	et	PROPN
dti-1331	51	17	al	al	PROPN
dti-1331	51	18	.	.	PROPN
dti-1331	51	19	1992	1992	NUM
dti-1331	51	20	;	;	PUNCT
dti-1331	51	21	wu	wu	PROPN
dti-1331	51	22	et	et	PROPN
dti-1331	51	23	al	al	PROPN
dti-1331	51	24	.	.	PROPN
dti-1331	51	25	1995	1995	NUM
dti-1331	51	26	)	)	PUNCT
dti-1331	51	27	and	and	CCONJ
dti-1331	51	28	augments	augment	VERB
dti-1331	51	29	nmda	nmda	ADJ
dti-1331	51	30	receptor	receptor	NOUN
dti-1331	51	31	mediated	mediate	VERB
dti-1331	51	32	transmission	transmission	NOUN
dti-1331	51	33	(	(	PUNCT
dti-1331	51	34	cullen	cullen	VERB
dti-1331	51	35	et	et	PROPN
dti-1331	51	36	al	al	PROPN
dti-1331	51	37	.	.	PROPN
dti-1331	51	38	1996	1996	NUM
dti-1331	51	39	)	)	PUNCT
dti-1331	51	40	.	.	PUNCT
dti-1331	52	1	in	in	ADP
dti-1331	52	2	vivo	vivo	ADJ
dti-1331	52	3	injection	injection	NOUN
dti-1331	52	4	of	of	ADP
dti-1331	52	5	beta	beta	NOUN
dti-1331	52	6	-	-	PUNCT
dti-1331	52	7	amyloid	amyloid	NOUN
dti-1331	52	8	produces	produce	VERB
dti-1331	52	9	long	long	ADV
dti-1331	52	10	lasting	last	VERB
dti-1331	52	11	depression	depression	NOUN
dti-1331	52	12	of	of	ADP
dti-1331	52	13	epsps	epsps	NOUN
dti-1331	52	14	in	in	ADP
dti-1331	52	15	the	the	DET
dti-1331	52	16	hippocampus	hippocampus	NOUN
dti-1331	52	17	,	,	PUNCT
dti-1331	52	18	which	which	PRON
dti-1331	52	19	is	be	AUX
dti-1331	52	20	an	an	DET
dti-1331	52	21	expression	expression	NOUN
dti-1331	52	22	of	of	ADP
dti-1331	52	23	ongoing	ongoing	ADJ
dti-1331	52	24	mild	mild	ADJ
dti-1331	52	25	excitotoxicity	excitotoxicity	NOUN
dti-1331	52	26	.	.	PUNCT
dti-1331	53	1	it	it	PRON
dti-1331	53	2	is	be	AUX
dti-1331	53	3	prevented	prevent	VERB
dti-1331	53	4	by	by	ADP
dti-1331	53	5	the	the	DET
dti-1331	53	6	nmda	nmda	ADJ
dti-1331	53	7	receptor	receptor	NOUN
dti-1331	53	8	antagonist	antagonist	NOUN
dti-1331	53	9	3-(2	3-(2	PROPN
dti-1331	53	10	-	-	PUNCT
dti-1331	53	11	carboxypiperazin4	carboxypiperazin4	NOUN
dti-1331	53	12	-	-	PUNCT
dti-1331	53	13	yl)propyl-1	yl)propyl-1	NOUN
dti-1331	53	14	-	-	PUNCT
dti-1331	53	15	phosphonic	phosphonic	ADJ
dti-1331	53	16	acid	acid	NOUN
dti-1331	53	17	(	(	PUNCT
dti-1331	53	18	cpp	cpp	NOUN
dti-1331	53	19	)	)	PUNCT
dti-1331	53	20	(	(	PUNCT
dti-1331	53	21	cullen	cullen	VERB
dti-1331	53	22	et	et	PROPN
dti-1331	53	23	al	al	PROPN
dti-1331	53	24	.	.	PROPN
dti-1331	53	25	1996	1996	NUM
dti-1331	53	26	)	)	PUNCT
dti-1331	53	27	.	.	PUNCT
dti-1331	54	1	in	in	ADP
dti-1331	54	2	multi	multi	ADJ
dti-1331	54	3	centre	centre	PROPN
dti-1331	54	4	placebo	placebo	NOUN
dti-1331	54	5	-	-	PUNCT
dti-1331	54	6	controlled	control	VERB
dti-1331	54	7	trials	trial	NOUN
dti-1331	54	8	,	,	PUNCT
dti-1331	54	9	memantine	memantine	NOUN
dti-1331	54	10	has	have	AUX
dti-1331	54	11	demonstrated	demonstrate	VERB
dti-1331	54	12	effi	effi	PROPN
dti-1331	54	13	cacy	cacy	NOUN
dti-1331	54	14	and	and	CCONJ
dti-1331	54	15	safety	safety	NOUN
dti-1331	54	16	79	79	NUM
dti-1331	54	17	memantine	memantine	NOUN
dti-1331	54	18	:	:	PUNCT
dti-1331	54	19	reality	reality	NOUN
dti-1331	54	20	and	and	CCONJ
dti-1331	54	21	potentiality	potentiality	NOUN
dti-1331	54	22	drug	drug	NOUN
dti-1331	54	23	target	target	NOUN
dti-1331	54	24	insights	insight	NOUN
dti-1331	54	25	2008:3	2008:3	NUM
dti-1331	54	26	in	in	ADP
dti-1331	54	27	ad	ad	NOUN
dti-1331	54	28	patients	patient	NOUN
dti-1331	54	29	.	.	PUNCT
dti-1331	55	1	the	the	DET
dti-1331	55	2	n	n	CCONJ
dti-1331	55	3	-	-	PUNCT
dti-1331	55	4	methyl	methyl	NOUN
dti-1331	55	5	-	-	PUNCT
dti-1331	55	6	d	d	NOUN
dti-1331	55	7	-	-	NOUN
dti-1331	55	8	aspartate	aspartate	ADJ
dti-1331	55	9	(	(	PUNCT
dti-1331	55	10	nmda	nmda	ADJ
dti-1331	55	11	)	)	PUNCT
dti-1331	55	12	antagonist	antagonist	NOUN
dti-1331	55	13	memantine	memantine	NOUN
dti-1331	55	14	has	have	AUX
dti-1331	55	15	been	be	AUX
dti-1331	55	16	shown	show	VERB
dti-1331	55	17	to	to	PART
dti-1331	55	18	be	be	AUX
dti-1331	55	19	effective	effective	ADJ
dti-1331	55	20	in	in	ADP
dti-1331	55	21	moderately	moderately	ADV
dti-1331	55	22	-	-	PUNCT
dti-1331	55	23	severe	severe	ADJ
dti-1331	55	24	to	to	ADP
dti-1331	55	25	severe	severe	ADJ
dti-1331	55	26	ad	ad	NOUN
dti-1331	55	27	.	.	PUNCT
dti-1331	56	1	252	252	NUM
dti-1331	56	2	patients	patient	NOUN
dti-1331	56	3	were	be	AUX
dti-1331	56	4	enrolled	enrol	VERB
dti-1331	56	5	,	,	PUNCT
dti-1331	56	6	with	with	ADP
dti-1331	56	7	equal	equal	ADJ
dti-1331	56	8	numbers	number	NOUN
dti-1331	56	9	(	(	PUNCT
dti-1331	56	10	n	n	NOUN
dti-1331	56	11	=	=	SYM
dti-1331	56	12	126	126	NUM
dti-1331	56	13	)	)	PUNCT
dti-1331	56	14	receiving	receive	VERB
dti-1331	56	15	either	either	CCONJ
dti-1331	56	16	memantine	memantine	ADJ
dti-1331	56	17	20	20	NUM
dti-1331	56	18	mg	mg	NUM
dti-1331	56	19	/	/	SYM
dti-1331	56	20	day	day	NOUN
dti-1331	56	21	or	or	CCONJ
dti-1331	56	22	placebo	placebo	NOUN
dti-1331	56	23	for	for	ADP
dti-1331	56	24	28	28	NUM
dti-1331	56	25	weeks	week	NOUN
dti-1331	56	26	.	.	PUNCT
dti-1331	57	1	effi	effi	PROPN
dti-1331	57	2	cacy	cacy	PROPN
dti-1331	57	3	was	be	AUX
dti-1331	57	4	assessed	assess	VERB
dti-1331	57	5	using	use	VERB
dti-1331	57	6	the	the	DET
dti-1331	57	7	clinician	clinician	NOUN
dti-1331	57	8	’s	’s	PART
dti-1331	57	9	interview	interview	NOUN
dti-1331	57	10	-	-	PUNCT
dti-1331	57	11	based	base	VERB
dti-1331	57	12	impression	impression	NOUN
dti-1331	57	13	of	of	ADP
dti-1331	57	14	change	change	NOUN
dti-1331	57	15	(	(	PUNCT
dti-1331	57	16	nyu	nyu	PROPN
dti-1331	57	17	cibicplus	cibicplus	PROPN
dti-1331	57	18	)	)	PUNCT
dti-1331	57	19	,	,	PUNCT
dti-1331	57	20	the	the	DET
dti-1331	57	21	modified	modify	VERB
dti-1331	57	22	alzheimer	alzheimer	PROPN
dti-1331	57	23	’s	’s	PART
dti-1331	57	24	disease	disease	PROPN
dti-1331	57	25	cooperative	cooperative	ADJ
dti-1331	57	26	study	study	NOUN
dti-1331	57	27	activities	activity	NOUN
dti-1331	57	28	of	of	ADP
dti-1331	57	29	daily	daily	ADJ
dti-1331	57	30	living	living	NOUN
dti-1331	57	31	(	(	PUNCT
dti-1331	57	32	adcs	adcs	ADV
dti-1331	57	33	-	-	PUNCT
dti-1331	57	34	adlsev	adlsev	ADJ
dti-1331	57	35	)	)	PUNCT
dti-1331	57	36	inventory	inventory	NOUN
dti-1331	57	37	,	,	PUNCT
dti-1331	57	38	the	the	DET
dti-1331	57	39	severe	severe	ADJ
dti-1331	57	40	impairment	impairment	ADJ
dti-1331	57	41	battery	battery	NOUN
dti-1331	57	42	(	(	PUNCT
dti-1331	57	43	sib	sib	NOUN
dti-1331	57	44	)	)	PUNCT
dti-1331	57	45	,	,	PUNCT
dti-1331	57	46	and	and	CCONJ
dti-1331	57	47	functional	functional	ADJ
dti-1331	57	48	assessment	assessment	NOUN
dti-1331	57	49	staging	staging	NOUN
dti-1331	57	50	(	(	PUNCT
dti-1331	57	51	fast	fast	ADV
dti-1331	57	52	)	)	PUNCT
dti-1331	57	53	(	(	PUNCT
dti-1331	57	54	reisberg	reisberg	PROPN
dti-1331	57	55	et	et	PROPN
dti-1331	57	56	al	al	PROPN
dti-1331	57	57	.	.	PROPN
dti-1331	57	58	2003	2003	NUM
dti-1331	57	59	;	;	PUNCT
dti-1331	57	60	reisberg	reisberg	PROPN
dti-1331	57	61	et	et	PROPN
dti-1331	57	62	al	al	PROPN
dti-1331	57	63	.	.	PROPN
dti-1331	57	64	2000	2000	NUM
dti-1331	57	65	)	)	PUNCT
dti-1331	57	66	.	.	PUNCT
dti-1331	58	1	in	in	ADP
dti-1331	58	2	study	study	NOUN
dti-1331	58	3	two	two	NUM
dti-1331	58	4	,	,	PUNCT
dti-1331	58	5	166	166	NUM
dti-1331	58	6	patients	patient	NOUN
dti-1331	58	7	were	be	AUX
dti-1331	58	8	enrolled	enrol	VERB
dti-1331	58	9	to	to	ADP
dti-1331	58	10	the	the	DET
dti-1331	58	11	study	study	NOUN
dti-1331	58	12	and	and	CCONJ
dti-1331	58	13	randomised	randomise	VERB
dti-1331	58	14	to	to	PART
dti-1331	58	15	receive	receive	VERB
dti-1331	58	16	either	either	CCONJ
dti-1331	58	17	memantine	memantine	VERB
dti-1331	58	18	10	10	NUM
dti-1331	58	19	mg	mg	NUM
dti-1331	58	20	/	/	SYM
dti-1331	58	21	day	day	NOUN
dti-1331	58	22	or	or	CCONJ
dti-1331	58	23	placebo	placebo	NOUN
dti-1331	58	24	for	for	ADP
dti-1331	58	25	12	12	NUM
dti-1331	58	26	weeks	week	NOUN
dti-1331	58	27	.	.	PUNCT
dti-1331	59	1	the	the	DET
dti-1331	59	2	primary	primary	ADJ
dti-1331	59	3	effi	effi	PROPN
dti-1331	59	4	cacy	cacy	NOUN
dti-1331	59	5	endpoints	endpoint	NOUN
dti-1331	59	6	were	be	AUX
dti-1331	59	7	measured	measure	VERB
dti-1331	59	8	using	use	VERB
dti-1331	59	9	the	the	DET
dti-1331	59	10	clinical	clinical	ADJ
dti-1331	59	11	global	global	ADJ
dti-1331	59	12	impression	impression	NOUN
dti-1331	59	13	of	of	ADP
dti-1331	59	14	change	change	NOUN
dti-1331	59	15	(	(	PUNCT
dti-1331	59	16	cgi	cgi	X
dti-1331	59	17	-	-	PUNCT
dti-1331	59	18	c	c	NOUN
dti-1331	59	19	)	)	PUNCT
dti-1331	59	20	and	and	CCONJ
dti-1331	59	21	the	the	DET
dti-1331	59	22	behavioural	behavioural	ADJ
dti-1331	59	23	rating	rating	NOUN
dti-1331	59	24	scale	scale	NOUN
dti-1331	59	25	for	for	ADP
dti-1331	59	26	geriatric	geriatric	ADJ
dti-1331	59	27	patients	patient	NOUN
dti-1331	59	28	(	(	PUNCT
dti-1331	59	29	bgp	bgp	PROPN
dti-1331	59	30	)	)	PUNCT
dti-1331	59	31	.	.	PUNCT
dti-1331	60	1	the	the	DET
dti-1331	60	2	modifi	modifi	PROPN
dti-1331	60	3	ed	ed	PROPN
dti-1331	60	4	d	d	NOUN
dti-1331	60	5	-	-	PUNCT
dti-1331	60	6	scale	scale	NOUN
dti-1331	60	7	(	(	PUNCT
dti-1331	60	8	arnold	arnold	PROPN
dti-1331	60	9	/	/	SYM
dti-1331	60	10	ferm	ferm	PROPN
dti-1331	60	11	)	)	PUNCT
dti-1331	60	12	was	be	AUX
dti-1331	60	13	used	use	VERB
dti-1331	60	14	to	to	PART
dti-1331	60	15	assess	assess	VERB
dti-1331	60	16	basic	basic	ADJ
dti-1331	60	17	activities	activity	NOUN
dti-1331	60	18	of	of	ADP
dti-1331	60	19	daily	daily	ADJ
dti-1331	60	20	living	live	VERB
dti-1331	60	21	as	as	ADP
dti-1331	60	22	a	a	DET
dti-1331	60	23	secondary	secondary	ADJ
dti-1331	60	24	endpoint	endpoint	NOUN
dti-1331	60	25	.	.	PUNCT
dti-1331	61	1	both	both	DET
dti-1331	61	2	studies	study	NOUN
dti-1331	61	3	demonstrated	demonstrate	VERB
dti-1331	61	4	that	that	SCONJ
dti-1331	61	5	patients	patient	NOUN
dti-1331	61	6	treated	treat	VERB
dti-1331	61	7	with	with	ADP
dti-1331	61	8	memantine	memantine	ADJ
dti-1331	61	9	show	show	NOUN
dti-1331	61	10	improvements	improvement	NOUN
dti-1331	61	11	in	in	ADP
dti-1331	61	12	the	the	DET
dti-1331	61	13	three	three	NUM
dti-1331	61	14	main	main	ADJ
dti-1331	61	15	ad	ad	NOUN
dti-1331	61	16	domains	domain	NOUN
dti-1331	61	17	:	:	PUNCT
dti-1331	61	18	function	function	NOUN
dti-1331	61	19	,	,	PUNCT
dti-1331	61	20	cognition	cognition	NOUN
dti-1331	61	21	and	and	CCONJ
dti-1331	61	22	global	global	ADJ
dti-1331	61	23	response	response	NOUN
dti-1331	61	24	.	.	PUNCT
dti-1331	62	1	memantine	memantine	PROPN
dti-1331	62	2	was	be	AUX
dti-1331	62	3	well	well	ADV
dti-1331	62	4	tolerated	tolerate	VERB
dti-1331	62	5	in	in	ADP
dti-1331	62	6	both	both	DET
dti-1331	62	7	studies	study	NOUN
dti-1331	62	8	,	,	PUNCT
dti-1331	62	9	being	be	AUX
dti-1331	62	10	the	the	DET
dti-1331	62	11	incidence	incidence	NOUN
dti-1331	62	12	of	of	ADP
dti-1331	62	13	adverse	adverse	ADJ
dti-1331	62	14	events	event	NOUN
dti-1331	62	15	(	(	PUNCT
dti-1331	62	16	aes	aes	NOUN
dti-1331	62	17	)	)	PUNCT
dti-1331	62	18	and	and	CCONJ
dti-1331	62	19	serious	serious	ADJ
dti-1331	62	20	aes	aes	PROPN
dti-1331	62	21	was	be	AUX
dti-1331	62	22	similar	similar	ADJ
dti-1331	62	23	in	in	ADP
dti-1331	62	24	both	both	DET
dti-1331	62	25	groups	group	NOUN
dti-1331	62	26	(	(	PUNCT
dti-1331	62	27	winblad	winblad	VERB
dti-1331	62	28	et	et	PROPN
dti-1331	62	29	al	al	PROPN
dti-1331	62	30	.	.	PROPN
dti-1331	62	31	1999	1999	NUM
dti-1331	62	32	)	)	PUNCT
dti-1331	62	33	.	.	PUNCT
dti-1331	63	1	in	in	ADP
dti-1331	63	2	conclusion	conclusion	NOUN
dti-1331	63	3	,	,	PUNCT
dti-1331	63	4	memantine	memantine	ADJ
dti-1331	63	5	treatment	treatment	NOUN
dti-1331	63	6	offered	offer	VERB
dti-1331	63	7	functional	functional	ADJ
dti-1331	63	8	improvements	improvement	NOUN
dti-1331	63	9	and	and	CCONJ
dti-1331	63	10	reduced	reduce	VERB
dti-1331	63	11	care	care	NOUN
dti-1331	63	12	dependence	dependence	NOUN
dti-1331	63	13	for	for	ADP
dti-1331	63	14	patients	patient	NOUN
dti-1331	63	15	with	with	ADP
dti-1331	63	16	moderately	moderately	ADV
dti-1331	63	17	-	-	PUNCT
dti-1331	63	18	severe	severe	ADJ
dti-1331	63	19	to	to	ADP
dti-1331	63	20	severe	severe	ADJ
dti-1331	63	21	ad	ad	NOUN
dti-1331	63	22	.	.	PUNCT
dti-1331	64	1	another	another	DET
dti-1331	64	2	well	well	ADV
dti-1331	64	3	designed	design	VERB
dti-1331	64	4	study	study	NOUN
dti-1331	64	5	,	,	PUNCT
dti-1331	64	6	involving	involve	VERB
dti-1331	64	7	patients	patient	NOUN
dti-1331	64	8	with	with	ADP
dti-1331	64	9	moderate	moderate	ADJ
dti-1331	64	10	-	-	PUNCT
dti-1331	64	11	to	to	ADP
dti-1331	64	12	-	-	PUNCT
dti-1331	64	13	severe	severe	ADJ
dti-1331	64	14	alzheimer	alzheimer	PROPN
dti-1331	64	15	’s	’s	PART
dti-1331	64	16	disease	disease	NOUN
dti-1331	64	17	,	,	PUNCT
dti-1331	64	18	who	who	PRON
dti-1331	64	19	were	be	AUX
dti-1331	64	20	randomly	randomly	ADV
dti-1331	64	21	assigned	assign	VERB
dti-1331	64	22	to	to	PART
dti-1331	64	23	receive	receive	VERB
dti-1331	64	24	placebo	placebo	NOUN
dti-1331	64	25	or	or	CCONJ
dti-1331	64	26	20	20	NUM
dti-1331	64	27	mg	mg	NOUN
dti-1331	64	28	of	of	ADP
dti-1331	64	29	memantine	memantine	NOUN
dti-1331	64	30	daily	daily	ADV
dti-1331	64	31	for	for	ADP
dti-1331	64	32	28	28	NUM
dti-1331	64	33	weeks	week	NOUN
dti-1331	64	34	has	have	AUX
dti-1331	64	35	been	be	AUX
dti-1331	64	36	conducted	conduct	VERB
dti-1331	64	37	(	(	PUNCT
dti-1331	64	38	bleich	bleich	NOUN
dti-1331	64	39	et	et	PROPN
dti-1331	64	40	al	al	PROPN
dti-1331	64	41	.	.	PROPN
dti-1331	64	42	2003	2003	NUM
dti-1331	64	43	)	)	PUNCT
dti-1331	64	44	.	.	PUNCT
dti-1331	65	1	252	252	NUM
dti-1331	65	2	patients	patient	NOUN
dti-1331	65	3	were	be	AUX
dti-1331	65	4	enrolled	enrol	VERB
dti-1331	65	5	.	.	PUNCT
dti-1331	66	1	of	of	ADP
dti-1331	66	2	these	these	PRON
dti-1331	66	3	,	,	PUNCT
dti-1331	66	4	181	181	NUM
dti-1331	66	5	(	(	PUNCT
dti-1331	66	6	72	72	NUM
dti-1331	66	7	%	%	NOUN
dti-1331	66	8	)	)	PUNCT
dti-1331	66	9	completed	complete	VERB
dti-1331	66	10	the	the	DET
dti-1331	66	11	study	study	NOUN
dti-1331	66	12	and	and	CCONJ
dti-1331	66	13	were	be	AUX
dti-1331	66	14	evaluated	evaluate	VERB
dti-1331	66	15	at	at	ADP
dti-1331	66	16	week	week	NOUN
dti-1331	66	17	28	28	NUM
dti-1331	66	18	.	.	PUNCT
dti-1331	67	1	71	71	NUM
dti-1331	67	2	patients	patient	NOUN
dti-1331	67	3	discontinued	discontinue	VERB
dti-1331	67	4	treatment	treatment	NOUN
dti-1331	67	5	prematurely	prematurely	ADV
dti-1331	67	6	(	(	PUNCT
dti-1331	67	7	42	42	NUM
dti-1331	67	8	taking	take	VERB
dti-1331	67	9	placebo	placebo	NOUN
dti-1331	67	10	and	and	CCONJ
dti-1331	67	11	29	29	NUM
dti-1331	67	12	taking	take	VERB
dti-1331	67	13	memantine	memantine	NOUN
dti-1331	67	14	)	)	PUNCT
dti-1331	67	15	.	.	PUNCT
dti-1331	68	1	patients	patient	NOUN
dti-1331	68	2	receiving	receive	VERB
dti-1331	68	3	memantine	memantine	NOUN
dti-1331	68	4	had	have	VERB
dti-1331	68	5	a	a	DET
dti-1331	68	6	better	well	ADJ
dti-1331	68	7	outcome	outcome	NOUN
dti-1331	68	8	than	than	ADP
dti-1331	68	9	those	those	PRON
dti-1331	68	10	receiving	receive	VERB
dti-1331	68	11	placebo	placebo	NOUN
dti-1331	68	12	,	,	PUNCT
dti-1331	68	13	according	accord	VERB
dti-1331	68	14	to	to	ADP
dti-1331	68	15	the	the	DET
dti-1331	68	16	results	result	NOUN
dti-1331	68	17	of	of	ADP
dti-1331	68	18	the	the	DET
dti-1331	68	19	clinical	clinical	ADJ
dti-1331	68	20	global	global	ADJ
dti-1331	68	21	impression	impression	NOUN
dti-1331	68	22	(	(	PUNCT
dti-1331	68	23	p	p	NOUN
dti-1331	68	24	=	=	NOUN
dti-1331	68	25	0.06	0.06	NUM
dti-1331	68	26	with	with	ADP
dti-1331	68	27	the	the	DET
dti-1331	68	28	last	last	ADJ
dti-1331	68	29	observation	observation	NOUN
dti-1331	68	30	carried	carry	VERB
dti-1331	68	31	forward	forward	ADV
dti-1331	68	32	,	,	PUNCT
dti-1331	68	33	p	p	X
dti-1331	68	34	=	=	NOUN
dti-1331	68	35	0.03	0.03	NUM
dti-1331	68	36	for	for	ADP
dti-1331	68	37	observed	observed	ADJ
dti-1331	68	38	cases	case	NOUN
dti-1331	68	39	)	)	PUNCT
dti-1331	68	40	,	,	PUNCT
dti-1331	68	41	of	of	ADP
dti-1331	68	42	the	the	DET
dti-1331	68	43	activities	activity	NOUN
dti-1331	68	44	of	of	ADP
dti-1331	68	45	daily	daily	ADJ
dti-1331	68	46	living	living	NOUN
dti-1331	68	47	(	(	PUNCT
dti-1331	68	48	p	p	X
dti-1331	68	49	=	=	NOUN
dti-1331	68	50	0.02	0.02	NUM
dti-1331	68	51	with	with	ADP
dti-1331	68	52	the	the	DET
dti-1331	68	53	last	last	ADJ
dti-1331	68	54	observation	observation	NOUN
dti-1331	68	55	carried	carry	VERB
dti-1331	68	56	forward	forward	ADV
dti-1331	68	57	,	,	PUNCT
dti-1331	68	58	p	p	X
dti-1331	68	59	=	=	NOUN
dti-1331	68	60	0.003	0.003	NUM
dti-1331	68	61	for	for	ADP
dti-1331	68	62	observed	observed	ADJ
dti-1331	68	63	cases	case	NOUN
dti-1331	68	64	)	)	PUNCT
dti-1331	68	65	,	,	PUNCT
dti-1331	68	66	and	and	CCONJ
dti-1331	68	67	the	the	DET
dti-1331	68	68	severe	severe	ADJ
dti-1331	68	69	impairment	impairment	ADJ
dti-1331	68	70	battery	battery	NOUN
dti-1331	68	71	(	(	PUNCT
dti-1331	68	72	p	p	PROPN
dti-1331	68	73	�	�	PROPN
dti-1331	68	74	0.001	0.001	NUM
dti-1331	68	75	with	with	ADP
dti-1331	68	76	the	the	DET
dti-1331	68	77	last	last	ADJ
dti-1331	68	78	observation	observation	NOUN
dti-1331	68	79	carried	carry	VERB
dti-1331	68	80	forward	forward	ADV
dti-1331	68	81	,	,	PUNCT
dti-1331	68	82	p	p	X
dti-1331	68	83	=	=	NOUN
dti-1331	68	84	0.002	0.002	NUM
dti-1331	68	85	for	for	ADP
dti-1331	68	86	observed	observed	ADJ
dti-1331	68	87	cases	case	NOUN
dti-1331	68	88	)	)	PUNCT
dti-1331	68	89	.	.	PUNCT
dti-1331	69	1	memantine	memantine	PROPN
dti-1331	69	2	was	be	AUX
dti-1331	69	3	not	not	PART
dti-1331	69	4	associated	associate	VERB
dti-1331	69	5	with	with	ADP
dti-1331	69	6	a	a	DET
dti-1331	69	7	signifi	signifi	NOUN
dti-1331	69	8	ca	can	AUX
dti-1331	69	9	nt	not	PART
dti-1331	69	10	frequency	frequency	VERB
dti-1331	69	11	of	of	ADP
dti-1331	69	12	adverse	adverse	ADJ
dti-1331	69	13	events	event	NOUN
dti-1331	69	14	.	.	PUNCT
dti-1331	70	1	the	the	DET
dti-1331	70	2	conclusions	conclusion	NOUN
dti-1331	70	3	of	of	ADP
dti-1331	70	4	the	the	DET
dti-1331	70	5	authors	author	NOUN
dti-1331	70	6	are	be	AUX
dti-1331	70	7	well	well	ADV
dti-1331	70	8	stigmatized	stigmatize	VERB
dti-1331	70	9	by	by	ADP
dti-1331	70	10	the	the	DET
dti-1331	70	11	following	follow	VERB
dti-1331	70	12	sentence	sentence	NOUN
dti-1331	70	13	:	:	PUNCT
dti-1331	70	14	“	"	PUNCT
dti-1331	70	15	antiglutamatergic	antiglutamatergic	ADJ
dti-1331	70	16	treatment	treatment	NOUN
dti-1331	70	17	reduced	reduce	VERB
dti-1331	70	18	clinical	clinical	ADJ
dti-1331	70	19	deterioration	deterioration	NOUN
dti-1331	70	20	in	in	ADP
dti-1331	70	21	moderate	moderate	ADJ
dti-1331	70	22	-	-	PUNCT
dti-1331	70	23	to	to	ADP
dti-1331	70	24	-	-	PUNCT
dti-1331	70	25	severe	severe	ADJ
dti-1331	70	26	alzheimer	alzheimer	PROPN
dti-1331	70	27	’s	’s	PART
dti-1331	70	28	disease	disease	NOUN
dti-1331	70	29	,	,	PUNCT
dti-1331	70	30	a	a	DET
dti-1331	70	31	phase	phase	NOUN
dti-1331	70	32	associated	associate	VERB
dti-1331	70	33	with	with	ADP
dti-1331	70	34	distress	distress	NOUN
dti-1331	70	35	for	for	ADP
dti-1331	70	36	patients	patient	NOUN
dti-1331	70	37	and	and	CCONJ
dti-1331	70	38	burden	burden	NOUN
dti-1331	70	39	on	on	ADP
dti-1331	70	40	caregivers	caregiver	NOUN
dti-1331	70	41	,	,	PUNCT
dti-1331	70	42	for	for	ADP
dti-1331	70	43	which	which	PRON
dti-1331	70	44	other	other	ADJ
dti-1331	70	45	treatments	treatment	NOUN
dti-1331	70	46	are	be	AUX
dti-1331	70	47	not	not	PART
dti-1331	70	48	available	available	ADJ
dti-1331	70	49	”	"	PUNCT
dti-1331	70	50	(	(	PUNCT
dti-1331	70	51	bleich	bleich	NOUN
dti-1331	70	52	et	et	PROPN
dti-1331	70	53	al	al	PROPN
dti-1331	70	54	.	.	PROPN
dti-1331	70	55	2003	2003	NUM
dti-1331	70	56	)	)	PUNCT
dti-1331	70	57	.	.	PUNCT
dti-1331	71	1	it	it	PRON
dti-1331	71	2	has	have	AUX
dti-1331	71	3	been	be	AUX
dti-1331	71	4	demonstrated	demonstrate	VERB
dti-1331	71	5	a	a	DET
dti-1331	71	6	favourable	favourable	ADJ
dti-1331	71	7	effect	effect	NOUN
dti-1331	71	8	of	of	ADP
dti-1331	71	9	memantine	memantine	NOUN
dti-1331	71	10	,	,	PUNCT
dti-1331	71	11	even	even	ADV
dti-1331	71	12	in	in	ADP
dti-1331	71	13	the	the	DET
dti-1331	71	14	association	association	NOUN
dti-1331	71	15	with	with	ADP
dti-1331	71	16	cholinesterase	cholinesterase	NOUN
dti-1331	71	17	inhibitors	inhibitor	NOUN
dti-1331	71	18	.	.	PUNCT
dti-1331	72	1	a	a	DET
dti-1331	72	2	24	24	NUM
dti-1331	72	3	-	-	PUNCT
dti-1331	72	4	week	week	NOUN
dti-1331	72	5	,	,	PUNCT
dti-1331	72	6	randomised	randomise	VERB
dti-1331	72	7	,	,	PUNCT
dti-1331	72	8	doubleblind	doubleblind	NOUN
dti-1331	72	9	,	,	PUNCT
dti-1331	72	10	parallel	parallel	NOUN
dti-1331	72	11	-	-	PUNCT
dti-1331	72	12	arm	arm	NOUN
dti-1331	72	13	,	,	PUNCT
dti-1331	72	14	placebo	placebo	NOUN
dti-1331	72	15	controlled	control	VERB
dti-1331	72	16	trial	trial	NOUN
dti-1331	72	17	was	be	AUX
dti-1331	72	18	performed	perform	VERB
dti-1331	72	19	in	in	ADP
dti-1331	72	20	37	37	NUM
dti-1331	72	21	us	us	PROPN
dti-1331	72	22	centres	centre	NOUN
dti-1331	72	23	to	to	PART
dti-1331	72	24	study	study	VERB
dti-1331	72	25	the	the	DET
dti-1331	72	26	safety	safety	NOUN
dti-1331	72	27	and	and	CCONJ
dti-1331	72	28	effi	effi	PROPN
dti-1331	72	29	cacy	cacy	NOUN
dti-1331	72	30	of	of	ADP
dti-1331	72	31	memantine	memantine	NOUN
dti-1331	72	32	in	in	ADP
dti-1331	72	33	patients	patient	NOUN
dti-1331	72	34	with	with	ADP
dti-1331	72	35	moderate	moderate	ADJ
dti-1331	72	36	to	to	ADP
dti-1331	72	37	severe	severe	ADJ
dti-1331	72	38	ad	ad	NOUN
dti-1331	72	39	treated	treat	VERB
dti-1331	72	40	with	with	ADP
dti-1331	72	41	donepezil	donepezil	NOUN
dti-1331	72	42	(	(	PUNCT
dti-1331	72	43	hartmann	hartmann	PROPN
dti-1331	72	44	et	et	PROPN
dti-1331	72	45	al	al	PROPN
dti-1331	72	46	.	.	PROPN
dti-1331	72	47	2003	2003	NUM
dti-1331	72	48	)	)	PUNCT
dti-1331	72	49	.	.	PUNCT
dti-1331	73	1	inclusion	inclusion	NOUN
dti-1331	73	2	criteria	criterion	NOUN
dti-1331	73	3	of	of	ADP
dti-1331	73	4	the	the	DET
dti-1331	73	5	study	study	NOUN
dti-1331	73	6	were	be	AUX
dti-1331	73	7	:	:	PUNCT
dti-1331	73	8	a	a	DET
dti-1331	73	9	diagnosis	diagnosis	NOUN
dti-1331	73	10	of	of	ADP
dti-1331	73	11	probable	probable	ADJ
dti-1331	73	12	ad	ad	NOUN
dti-1331	73	13	by	by	ADP
dti-1331	73	14	nincds	nincd	NOUN
dti-1331	73	15	-	-	ADJ
dti-1331	73	16	adrda	adrda	ADJ
dti-1331	73	17	,	,	PUNCT
dti-1331	73	18	mmse	mmse	PROPN
dti-1331	73	19	(	(	PUNCT
dti-1331	73	20	5–14	5–14	PROPN
dti-1331	73	21	)	)	PUNCT
dti-1331	73	22	,	,	PUNCT
dti-1331	73	23	mri	mri	NOUN
dti-1331	73	24	or	or	CCONJ
dti-1331	73	25	ct	ct	NOUN
dti-1331	73	26	scan	scan	NOUN
dti-1331	73	27	consistent	consistent	ADJ
dti-1331	73	28	with	with	ADP
dti-1331	73	29	probable	probable	ADJ
dti-1331	73	30	ad	ad	NOUN
dti-1331	73	31	,	,	PUNCT
dti-1331	73	32	and	and	CCONJ
dti-1331	73	33	6	6	NUM
dti-1331	73	34	-	-	PUNCT
dti-1331	73	35	month	month	NOUN
dti-1331	73	36	daily	daily	PROPN
dti-1331	73	37	achei	achei	PROPN
dti-1331	73	38	(	(	PUNCT
dti-1331	73	39	donepezil	donepezil	PROPN
dti-1331	73	40	)	)	PUNCT
dti-1331	73	41	therapy	therapy	NOUN
dti-1331	73	42	(	(	PUNCT
dti-1331	73	43	stable	stable	ADJ
dti-1331	73	44	dose	dose	NOUN
dti-1331	73	45	for	for	ADP
dti-1331	73	46	the	the	DET
dti-1331	73	47	past	past	ADJ
dti-1331	73	48	3	3	NUM
dti-1331	73	49	months	month	NOUN
dti-1331	73	50	)	)	PUNCT
dti-1331	73	51	.	.	PUNCT
dti-1331	74	1	primary	primary	ADJ
dti-1331	74	2	outcome	outcome	NOUN
dti-1331	74	3	assessments	assessment	NOUN
dti-1331	74	4	were	be	AUX
dti-1331	74	5	:	:	PUNCT
dti-1331	74	6	cognition	cognition	NOUN
dti-1331	74	7	and	and	CCONJ
dti-1331	74	8	function	function	NOUN
dti-1331	74	9	in	in	ADP
dti-1331	74	10	daily	daily	ADJ
dti-1331	74	11	living	living	NOUN
dti-1331	74	12	.	.	PUNCT
dti-1331	75	1	a	a	DET
dti-1331	75	2	pharmacokinetic	pharmacokinetic	ADJ
dti-1331	75	3	study	study	NOUN
dti-1331	75	4	in	in	ADP
dti-1331	75	5	24	24	NUM
dti-1331	75	6	healthy	healthy	ADJ
dti-1331	75	7	volunteers	volunteer	NOUN
dti-1331	75	8	showed	show	VERB
dti-1331	75	9	no	no	DET
dti-1331	75	10	pharmacokinetic	pharmacokinetic	ADJ
dti-1331	75	11	or	or	CCONJ
dti-1331	75	12	pharmacodynamic	pharmacodynamic	ADJ
dti-1331	75	13	interactions	interaction	NOUN
dti-1331	75	14	and	and	CCONJ
dti-1331	75	15	the	the	DET
dti-1331	75	16	combination	combination	NOUN
dti-1331	75	17	was	be	AUX
dti-1331	75	18	well	well	ADV
dti-1331	75	19	tolerated	tolerate	VERB
dti-1331	75	20	.	.	PUNCT
dti-1331	76	1	the	the	DET
dti-1331	76	2	global	global	ADJ
dti-1331	76	3	effect	effect	NOUN
dti-1331	76	4	was	be	AUX
dti-1331	76	5	in	in	ADP
dti-1331	76	6	general	general	ADJ
dti-1331	76	7	favourable	favourable	ADJ
dti-1331	76	8	to	to	ADP
dti-1331	76	9	the	the	DET
dti-1331	76	10	population	population	NOUN
dti-1331	76	11	who	who	PRON
dti-1331	76	12	received	receive	VERB
dti-1331	76	13	both	both	CCONJ
dti-1331	76	14	the	the	DET
dti-1331	76	15	drugs	drug	NOUN
dti-1331	76	16	.	.	PUNCT
dti-1331	77	1	a	a	DET
dti-1331	77	2	postmarketing	postmarketing	NOUN
dti-1331	77	3	surveillance	surveillance	NOUN
dti-1331	77	4	study	study	NOUN
dti-1331	77	5	was	be	AUX
dti-1331	77	6	performed	perform	VERB
dti-1331	77	7	in	in	ADP
dti-1331	77	8	germany	germany	PROPN
dti-1331	77	9	to	to	PART
dti-1331	77	10	assess	assess	VERB
dti-1331	77	11	the	the	DET
dti-1331	77	12	tolerability	tolerability	NOUN
dti-1331	77	13	of	of	ADP
dti-1331	77	14	memantine	memantine	NOUN
dti-1331	77	15	in	in	ADP
dti-1331	77	16	combination	combination	NOUN
dti-1331	77	17	with	with	ADP
dti-1331	77	18	an	an	DET
dti-1331	77	19	achei	achei	NOUN
dti-1331	77	20	(	(	PUNCT
dti-1331	77	21	84	84	NUM
dti-1331	77	22	%	%	NOUN
dti-1331	77	23	donepezil	donepezil	NOUN
dti-1331	77	24	and	and	CCONJ
dti-1331	77	25	15	15	NUM
dti-1331	77	26	%	%	NOUN
dti-1331	77	27	rivastigmine	rivastigmine	NOUN
dti-1331	77	28	)	)	PUNCT
dti-1331	77	29	based	base	VERB
dti-1331	77	30	on	on	ADP
dti-1331	77	31	200	200	NUM
dti-1331	77	32	questionnaires	questionnaire	NOUN
dti-1331	77	33	.	.	PUNCT
dti-1331	78	1	the	the	DET
dti-1331	78	2	results	result	NOUN
dti-1331	78	3	demonstrate	demonstrate	VERB
dti-1331	78	4	that	that	SCONJ
dti-1331	78	5	combining	combine	VERB
dti-1331	78	6	memantine	memantine	NOUN
dti-1331	78	7	with	with	ADP
dti-1331	78	8	a	a	DET
dti-1331	78	9	commonly	commonly	ADV
dti-1331	78	10	used	use	VERB
dti-1331	78	11	achei	achei	PROPN
dti-1331	78	12	is	be	AUX
dti-1331	78	13	safe	safe	ADJ
dti-1331	78	14	and	and	CCONJ
dti-1331	78	15	superior	superior	ADJ
dti-1331	78	16	to	to	ADP
dti-1331	78	17	the	the	DET
dti-1331	78	18	achei	achei	PROPN
dti-1331	78	19	alone	alone	ADV
dti-1331	78	20	in	in	ADP
dti-1331	78	21	moderate	moderate	ADJ
dti-1331	78	22	to	to	ADP
dti-1331	78	23	severe	severe	ADJ
dti-1331	78	24	ad	ad	NOUN
dti-1331	78	25	(	(	PUNCT
dti-1331	78	26	tariot	tariot	NOUN
dti-1331	78	27	et	et	PROPN
dti-1331	78	28	al	al	PROPN
dti-1331	78	29	.	.	PROPN
dti-1331	78	30	2003	2003	NUM
dti-1331	78	31	;	;	PUNCT
dti-1331	78	32	tariot	tariot	PROPN
dti-1331	78	33	et	et	PROPN
dti-1331	78	34	al	al	PROPN
dti-1331	78	35	.	.	PROPN
dti-1331	78	36	2004	2004	NUM
dti-1331	78	37	;	;	PUNCT
dti-1331	78	38	knopman	knopman	NOUN
dti-1331	78	39	,	,	PUNCT
dti-1331	78	40	2005	2005	NUM
dti-1331	78	41	;	;	PUNCT
dti-1331	78	42	pomara	pomara	PROPN
dti-1331	78	43	et	et	PROPN
dti-1331	78	44	al	al	PROPN
dti-1331	78	45	.	.	PROPN
dti-1331	78	46	2004	2004	NUM
dti-1331	78	47	;	;	PUNCT
dti-1331	78	48	sudhir	sudhir	PROPN
dti-1331	78	49	,	,	PUNCT
dti-1331	78	50	2004	2004	NUM
dti-1331	78	51	)	)	PUNCT
dti-1331	78	52	.	.	PUNCT
dti-1331	79	1	to	to	PART
dti-1331	79	2	investigate	investigate	VERB
dti-1331	79	3	,	,	PUNCT
dti-1331	79	4	the	the	DET
dti-1331	79	5	cognitive	cognitive	ADJ
dti-1331	79	6	effect	effect	NOUN
dti-1331	79	7	of	of	ADP
dti-1331	79	8	the	the	DET
dti-1331	79	9	memantine	memantine	NOUN
dti-1331	79	10	,	,	PUNCT
dti-1331	79	11	a	a	DET
dti-1331	79	12	group	group	NOUN
dti-1331	79	13	of	of	ADP
dti-1331	79	14	scientists	scientist	NOUN
dti-1331	79	15	(	(	PUNCT
dti-1331	79	16	schmitt	schmitt	X
dti-1331	79	17	et	et	PROPN
dti-1331	79	18	al	al	PROPN
dti-1331	79	19	.	.	PROPN
dti-1331	79	20	2006	2006	NUM
dti-1331	79	21	)	)	PUNCT
dti-1331	79	22	executed	execute	VERB
dti-1331	79	23	a	a	DET
dti-1331	79	24	post	post	ADJ
dti-1331	79	25	-	-	ADJ
dti-1331	79	26	hoc	hoc	ADJ
dti-1331	79	27	exploratory	exploratory	ADJ
dti-1331	79	28	reanalysis	reanalysis	NOUN
dti-1331	79	29	of	of	ADP
dti-1331	79	30	a	a	DET
dti-1331	79	31	24	24	NUM
dti-1331	79	32	week	week	NOUN
dti-1331	79	33	randomized	randomize	VERB
dti-1331	79	34	,	,	PUNCT
dti-1331	79	35	double	double	ADJ
dti-1331	79	36	-	-	PUNCT
dti-1331	79	37	blind	blind	ADJ
dti-1331	79	38	,	,	PUNCT
dti-1331	79	39	placebocontrolled	placebocontrolle	VERB
dti-1331	79	40	,	,	PUNCT
dti-1331	79	41	parallel	parallel	ADJ
dti-1331	79	42	group	group	NOUN
dti-1331	79	43	clinical	clinical	ADJ
dti-1331	79	44	trial	trial	NOUN
dti-1331	79	45	comparing	compare	VERB
dti-1331	79	46	memantine	memantine	NOUN
dti-1331	79	47	to	to	PART
dti-1331	79	48	placebo	placebo	VERB
dti-1331	79	49	in	in	ADP
dti-1331	79	50	patients	patient	NOUN
dti-1331	79	51	with	with	ADP
dti-1331	79	52	moderate	moderate	ADJ
dti-1331	79	53	to	to	ADP
dti-1331	79	54	severe	severe	ADJ
dti-1331	79	55	ad	ad	NOUN
dti-1331	79	56	receiving	receive	VERB
dti-1331	79	57	treatment	treatment	NOUN
dti-1331	79	58	with	with	ADP
dti-1331	79	59	cholinesterase	cholinesterase	NOUN
dti-1331	79	60	inhibitor	inhibitor	NOUN
dti-1331	79	61	,	,	PUNCT
dti-1331	79	62	donepezil	donepezil	NOUN
dti-1331	79	63	.	.	PUNCT
dti-1331	80	1	these	these	DET
dti-1331	80	2	post	post	ADJ
dti-1331	80	3	-	-	ADJ
dti-1331	80	4	hoc	hoc	ADJ
dti-1331	80	5	analyses	analysis	NOUN
dti-1331	80	6	support	support	VERB
dti-1331	80	7	the	the	DET
dti-1331	80	8	benefi	benefi	PROPN
dti-1331	80	9	cial	cial	ADJ
dti-1331	80	10	effects	effect	NOUN
dti-1331	80	11	of	of	ADP
dti-1331	80	12	memantine	memantine	NOUN
dti-1331	80	13	on	on	ADP
dti-1331	80	14	cognition	cognition	NOUN
dti-1331	80	15	observed	observe	VERB
dti-1331	80	16	in	in	ADP
dti-1331	80	17	a	a	DET
dti-1331	80	18	previously	previously	ADV
dti-1331	80	19	reported	report	VERB
dti-1331	80	20	clinical	clinical	ADJ
dti-1331	80	21	trial	trial	NOUN
dti-1331	80	22	.	.	PUNCT
dti-1331	81	1	the	the	DET
dti-1331	81	2	results	result	NOUN
dti-1331	81	3	suggested	suggest	VERB
dti-1331	81	4	an	an	DET
dti-1331	81	5	effect	effect	NOUN
dti-1331	81	6	of	of	ADP
dti-1331	81	7	memantine	memantine	NOUN
dti-1331	81	8	on	on	ADP
dti-1331	81	9	memory	memory	NOUN
dti-1331	81	10	,	,	PUNCT
dti-1331	81	11	language	language	NOUN
dti-1331	81	12	,	,	PUNCT
dti-1331	81	13	and	and	CCONJ
dti-1331	81	14	praxis	praxi	VERB
dti-1331	81	15	in	in	ADP
dti-1331	81	16	patients	patient	NOUN
dti-1331	81	17	with	with	ADP
dti-1331	81	18	moderate	moderate	ADJ
dti-1331	81	19	to	to	ADP
dti-1331	81	20	severe	severe	ADJ
dti-1331	81	21	ad	ad	NOUN
dti-1331	81	22	and	and	CCONJ
dti-1331	81	23	support	support	VERB
dti-1331	81	24	the	the	DET
dti-1331	81	25	effi	effi	PROPN
dti-1331	81	26	cacy	cacy	NOUN
dti-1331	81	27	of	of	ADP
dti-1331	81	28	memantine	memantine	NOUN
dti-1331	81	29	for	for	ADP
dti-1331	81	30	the	the	DET
dti-1331	81	31	treatment	treatment	NOUN
dti-1331	81	32	of	of	ADP
dti-1331	81	33	cognitive	cognitive	ADJ
dti-1331	81	34	defects	defect	NOUN
dti-1331	81	35	in	in	ADP
dti-1331	81	36	ad	ad	NOUN
dti-1331	81	37	(	(	PUNCT
dti-1331	81	38	schmitt	schmitt	X
dti-1331	81	39	et	et	PROPN
dti-1331	81	40	al	al	PROPN
dti-1331	81	41	.	.	PROPN
dti-1331	81	42	2006	2006	NUM
dti-1331	81	43	)	)	PUNCT
dti-1331	81	44	.	.	PUNCT
dti-1331	82	1	a	a	DET
dti-1331	82	2	very	very	ADV
dti-1331	82	3	recent	recent	ADJ
dti-1331	82	4	work	work	NOUN
dti-1331	82	5	(	(	PUNCT
dti-1331	82	6	jones	jones	PROPN
dti-1331	82	7	et	et	PROPN
dti-1331	82	8	al	al	PROPN
dti-1331	82	9	.	.	PROPN
dti-1331	82	10	2007	2007	NUM
dti-1331	82	11	)	)	PUNCT
dti-1331	82	12	confi	confi	PROPN
dti-1331	82	13	rmed	rme	VERB
dti-1331	82	14	the	the	DET
dti-1331	82	15	statistically	statistically	ADV
dti-1331	82	16	signifi	signifi	NOUN
dti-1331	82	17	ca	can	AUX
dti-1331	82	18	nt	not	PART
dti-1331	82	19	benefi	benefi	VERB
dti-1331	82	20	ts	ts	ADP
dti-1331	82	21	of	of	ADP
dti-1331	82	22	memantine	memantine	NOUN
dti-1331	82	23	given	give	VERB
dti-1331	82	24	twice	twice	ADV
dti-1331	82	25	-	-	PUNCT
dti-1331	82	26	daily	daily	NOUN
dti-1331	82	27	to	to	PART
dti-1331	82	28	treat	treat	VERB
dti-1331	82	29	moderate	moderate	ADJ
dti-1331	82	30	to	to	ADP
dti-1331	82	31	severe	severe	ADJ
dti-1331	82	32	ad	ad	NOUN
dti-1331	82	33	have	have	AUX
dti-1331	82	34	already	already	ADV
dti-1331	82	35	been	be	AUX
dti-1331	82	36	80	80	NUM
dti-1331	82	37	moretti	moretti	PROPN
dti-1331	82	38	et	et	PROPN
dti-1331	82	39	al	al	PROPN
dti-1331	82	40	drug	drug	PROPN
dti-1331	82	41	target	target	NOUN
dti-1331	82	42	insights	insight	NOUN
dti-1331	82	43	2008:3	2008:3	NUM
dti-1331	82	44	shown	show	VERB
dti-1331	82	45	by	by	ADP
dti-1331	82	46	multiple	multiple	ADJ
dti-1331	82	47	studies	study	NOUN
dti-1331	82	48	in	in	ADP
dti-1331	82	49	pivotal	pivotal	ADJ
dti-1331	82	50	ad	ad	NOUN
dti-1331	82	51	domains	domain	NOUN
dti-1331	82	52	(	(	PUNCT
dti-1331	82	53	function	function	NOUN
dti-1331	82	54	,	,	PUNCT
dti-1331	82	55	cognition	cognition	NOUN
dti-1331	82	56	and	and	CCONJ
dti-1331	82	57	global	global	ADJ
dti-1331	82	58	performance	performance	NOUN
dti-1331	82	59	)	)	PUNCT
dti-1331	82	60	(	(	PUNCT
dti-1331	82	61	winblad	winblad	VERB
dti-1331	82	62	et	et	PROPN
dti-1331	82	63	al	al	PROPN
dti-1331	82	64	.	.	PROPN
dti-1331	82	65	2006	2006	NUM
dti-1331	82	66	)	)	PUNCT
dti-1331	82	67	.	.	PUNCT
dti-1331	83	1	no	no	DET
dti-1331	83	2	clinically	clinically	ADV
dti-1331	83	3	relevant	relevant	ADJ
dti-1331	83	4	differences	difference	NOUN
dti-1331	83	5	in	in	ADP
dti-1331	83	6	adverse	adverse	ADJ
dti-1331	83	7	effects	effect	NOUN
dti-1331	83	8	or	or	CCONJ
dti-1331	83	9	vital	vital	ADJ
dti-1331	83	10	signs	sign	NOUN
dti-1331	83	11	were	be	AUX
dti-1331	83	12	observed	observe	VERB
dti-1331	83	13	between	between	ADP
dti-1331	83	14	the	the	DET
dti-1331	83	15	different	different	ADJ
dti-1331	83	16	dosing	dose	VERB
dti-1331	83	17	schedules	schedule	NOUN
dti-1331	83	18	(	(	PUNCT
dti-1331	83	19	jones	jones	PROPN
dti-1331	83	20	et	et	PROPN
dti-1331	83	21	al	al	PROPN
dti-1331	83	22	.	.	PROPN
dti-1331	83	23	2007	2007	NUM
dti-1331	83	24	)	)	PUNCT
dti-1331	83	25	.	.	PUNCT
dti-1331	84	1	memantine	memantine	NOUN
dti-1331	84	2	and	and	CCONJ
dti-1331	84	3	vascular	vascular	ADJ
dti-1331	84	4	dementia	dementia	NOUN
dti-1331	84	5	in	in	ADP
dti-1331	84	6	course	course	NOUN
dti-1331	84	7	of	of	ADP
dti-1331	84	8	a	a	DET
dti-1331	84	9	cerebrovascular	cerebrovascular	ADJ
dti-1331	84	10	event	event	NOUN
dti-1331	84	11	,	,	PUNCT
dti-1331	84	12	there	there	PRON
dti-1331	84	13	is	be	VERB
dti-1331	84	14	a	a	DET
dti-1331	84	15	run	run	NOUN
dti-1331	84	16	-	-	PUNCT
dti-1331	84	17	down	down	NOUN
dti-1331	84	18	of	of	ADP
dti-1331	84	19	energy	energy	NOUN
dti-1331	84	20	in	in	ADP
dti-1331	84	21	neurons	neuron	NOUN
dti-1331	84	22	.	.	PUNCT
dti-1331	85	1	there	there	PRON
dti-1331	85	2	are	be	VERB
dti-1331	85	3	number	number	NOUN
dti-1331	85	4	of	of	ADP
dti-1331	85	5	microdialysis	microdialysis	NOUN
dti-1331	85	6	studies	study	NOUN
dti-1331	85	7	indicating	indicate	VERB
dti-1331	85	8	that	that	SCONJ
dti-1331	85	9	there	there	PRON
dti-1331	85	10	is	be	VERB
dti-1331	85	11	also	also	ADV
dti-1331	85	12	a	a	DET
dti-1331	85	13	consistent	consistent	ADJ
dti-1331	85	14	increase	increase	NOUN
dti-1331	85	15	in	in	ADP
dti-1331	85	16	extracellular	extracellular	ADJ
dti-1331	85	17	glutamate	glutamate	NOUN
dti-1331	85	18	concentration	concentration	NOUN
dti-1331	85	19	.	.	PUNCT
dti-1331	86	1	in	in	ADP
dti-1331	86	2	humans	human	NOUN
dti-1331	86	3	,	,	PUNCT
dti-1331	86	4	there	there	PRON
dti-1331	86	5	is	be	VERB
dti-1331	86	6	also	also	ADV
dti-1331	86	7	an	an	DET
dti-1331	86	8	increase	increase	NOUN
dti-1331	86	9	in	in	ADP
dti-1331	86	10	cerebrospinal	cerebrospinal	ADJ
dti-1331	86	11	fl	fl	X
dti-1331	86	12	uid	uid	ADJ
dti-1331	86	13	(	(	PUNCT
dti-1331	86	14	csf	csf	NOUN
dti-1331	86	15	)	)	PUNCT
dti-1331	86	16	and	and	CCONJ
dti-1331	86	17	plasma	plasma	NOUN
dti-1331	86	18	content	content	NOUN
dti-1331	86	19	of	of	ADP
dti-1331	86	20	glutamate	glutamate	NOUN
dti-1331	86	21	in	in	ADP
dti-1331	86	22	patients	patient	NOUN
dti-1331	86	23	with	with	ADP
dti-1331	86	24	progressive	progressive	ADJ
dti-1331	86	25	,	,	PUNCT
dti-1331	86	26	but	but	CCONJ
dti-1331	86	27	not	not	PART
dti-1331	86	28	stable	stable	ADJ
dti-1331	86	29	stroke	stroke	NOUN
dti-1331	86	30	.	.	PUNCT
dti-1331	87	1	thus	thus	ADV
dti-1331	87	2	,	,	PUNCT
dti-1331	87	3	other	other	ADJ
dti-1331	87	4	factors	factor	NOUN
dti-1331	87	5	may	may	AUX
dti-1331	87	6	increase	increase	VERB
dti-1331	87	7	neuronal	neuronal	ADJ
dti-1331	87	8	vulnerability	vulnerability	NOUN
dti-1331	87	9	to	to	ADP
dti-1331	87	10	physiological	physiological	ADJ
dti-1331	87	11	levels	level	NOUN
dti-1331	87	12	of	of	ADP
dti-1331	87	13	glutamate	glutamate	NOUN
dti-1331	87	14	by	by	ADP
dti-1331	87	15	,	,	PUNCT
dti-1331	87	16	for	for	ADP
dti-1331	87	17	example	example	NOUN
dti-1331	87	18	,	,	PUNCT
dti-1331	87	19	a	a	DET
dti-1331	87	20	decrease	decrease	NOUN
dti-1331	87	21	of	of	ADP
dti-1331	87	22	resting	rest	VERB
dti-1331	87	23	membrane	membrane	NOUN
dti-1331	87	24	potential	potential	NOUN
dti-1331	87	25	or	or	CCONJ
dti-1331	87	26	intracellular	intracellular	ADJ
dti-1331	87	27	buffering	buffering	NOUN
dti-1331	87	28	of	of	ADP
dti-1331	87	29	ca2	ca2	PROPN
dti-1331	87	30	+	+	PROPN
dti-1331	87	31	ions	ion	NOUN
dti-1331	87	32	.	.	PUNCT
dti-1331	88	1	apart	apart	ADV
dti-1331	88	2	from	from	ADP
dti-1331	88	3	glutamate	glutamate	NOUN
dti-1331	88	4	,	,	PUNCT
dti-1331	88	5	oxidative	oxidative	ADJ
dti-1331	88	6	stress	stress	NOUN
dti-1331	88	7	,	,	PUNCT
dti-1331	88	8	inflammatory	inflammatory	ADJ
dti-1331	88	9	reactions	reaction	NOUN
dti-1331	88	10	and	and	CCONJ
dti-1331	88	11	breakdown	breakdown	NOUN
dti-1331	88	12	of	of	ADP
dti-1331	88	13	the	the	DET
dti-1331	88	14	blood	blood	NOUN
dti-1331	88	15	-	-	PUNCT
dti-1331	88	16	brain	brain	NOUN
dti-1331	88	17	barrier	barrier	NOUN
dti-1331	88	18	may	may	AUX
dti-1331	88	19	also	also	ADV
dti-1331	88	20	play	play	VERB
dti-1331	88	21	a	a	DET
dti-1331	88	22	pivotal	pivotal	ADJ
dti-1331	88	23	role	role	NOUN
dti-1331	88	24	.	.	PUNCT
dti-1331	89	1	the	the	DET
dti-1331	89	2	toxic	toxic	ADJ
dti-1331	89	3	effects	effect	NOUN
dti-1331	89	4	of	of	ADP
dti-1331	89	5	glutamate	glutamate	NOUN
dti-1331	89	6	are	be	AUX
dti-1331	89	7	mediated	mediate	VERB
dti-1331	89	8	largely	largely	ADV
dti-1331	89	9	through	through	ADP
dti-1331	89	10	n	n	CCONJ
dti-1331	89	11	-	-	PUNCT
dti-1331	89	12	methyld	methyld	NOUN
dti-1331	89	13	-	-	PUNCT
dti-1331	89	14	aspartate	aspartate	NOUN
dti-1331	89	15	(	(	PUNCT
dti-1331	89	16	nmda	nmda	ADJ
dti-1331	89	17	)	)	PUNCT
dti-1331	89	18	receptors	receptor	NOUN
dti-1331	89	19	.	.	PUNCT
dti-1331	90	1	activation	activation	NOUN
dti-1331	90	2	of	of	ADP
dti-1331	90	3	nmda	nmda	ADJ
dti-1331	90	4	-	-	PUNCT
dti-1331	90	5	associated	associate	VERB
dti-1331	90	6	channels	channel	NOUN
dti-1331	90	7	leads	lead	VERB
dti-1331	90	8	to	to	ADP
dti-1331	90	9	the	the	DET
dti-1331	90	10	passage	passage	NOUN
dti-1331	90	11	of	of	ADP
dti-1331	90	12	sodium	sodium	NOUN
dti-1331	90	13	and	and	CCONJ
dti-1331	90	14	chloride	chloride	NOUN
dti-1331	90	15	into	into	ADP
dti-1331	90	16	the	the	DET
dti-1331	90	17	cell	cell	NOUN
dti-1331	90	18	followed	follow	VERB
dti-1331	90	19	by	by	ADP
dti-1331	90	20	the	the	DET
dti-1331	90	21	obligatory	obligatory	ADJ
dti-1331	90	22	movement	movement	NOUN
dti-1331	90	23	of	of	ADP
dti-1331	90	24	water	water	NOUN
dti-1331	90	25	resulting	result	VERB
dti-1331	90	26	in	in	ADP
dti-1331	90	27	cytotoxic	cytotoxic	ADJ
dti-1331	90	28	oedema	oedema	NOUN
dti-1331	90	29	.	.	PUNCT
dti-1331	91	1	if	if	SCONJ
dti-1331	91	2	calcium	calcium	NOUN
dti-1331	91	3	is	be	AUX
dti-1331	91	4	present	present	ADJ
dti-1331	91	5	early	early	ADV
dti-1331	91	6	,	,	PUNCT
dti-1331	91	7	it	it	PRON
dti-1331	91	8	tends	tend	VERB
dti-1331	91	9	to	to	PART
dti-1331	91	10	pass	pass	VERB
dti-1331	91	11	through	through	ADP
dti-1331	91	12	the	the	DET
dti-1331	91	13	channel	channel	NOUN
dti-1331	91	14	into	into	ADP
dti-1331	91	15	the	the	DET
dti-1331	91	16	cell	cell	NOUN
dti-1331	91	17	where	where	SCONJ
dti-1331	91	18	it	it	PRON
dti-1331	91	19	recruits	recruit	VERB
dti-1331	91	20	second	second	ADJ
dti-1331	91	21	messengers	messenger	NOUN
dti-1331	91	22	,	,	PUNCT
dti-1331	91	23	with	with	ADP
dti-1331	91	24	concomitant	concomitant	ADJ
dti-1331	91	25	activation	activation	NOUN
dti-1331	91	26	of	of	ADP
dti-1331	91	27	kinases	kinase	NOUN
dti-1331	91	28	and	and	CCONJ
dti-1331	91	29	proteases	protease	NOUN
dti-1331	91	30	that	that	PRON
dti-1331	91	31	eventually	eventually	ADV
dti-1331	91	32	lead	lead	VERB
dti-1331	91	33	to	to	ADP
dti-1331	91	34	irreversible	irreversible	ADJ
dti-1331	91	35	injury	injury	NOUN
dti-1331	91	36	.	.	PUNCT
dti-1331	92	1	this	this	PRON
dti-1331	92	2	is	be	AUX
dti-1331	92	3	believed	believe	VERB
dti-1331	92	4	to	to	PART
dti-1331	92	5	be	be	AUX
dti-1331	92	6	the	the	DET
dti-1331	92	7	underlying	underlying	ADJ
dti-1331	92	8	mechanism	mechanism	NOUN
dti-1331	92	9	behind	behind	ADP
dti-1331	92	10	delayed	delay	VERB
dti-1331	92	11	glutamate	glutamate	ADJ
dti-1331	92	12	toxicity	toxicity	NOUN
dti-1331	92	13	.	.	PUNCT
dti-1331	93	1	glutamate	glutamate	NOUN
dti-1331	93	2	excitotoxicity	excitotoxicity	NOUN
dti-1331	93	3	can	can	AUX
dti-1331	93	4	lead	lead	VERB
dti-1331	93	5	to	to	ADP
dti-1331	93	6	a	a	DET
dti-1331	93	7	state	state	NOUN
dti-1331	93	8	of	of	ADP
dti-1331	93	9	self	self	NOUN
dti-1331	93	10	-	-	PUNCT
dti-1331	93	11	amplifi	amplifi	NOUN
dti-1331	93	12	cation	cation	NOUN
dti-1331	93	13	,	,	PUNCT
dti-1331	93	14	followed	follow	VERB
dti-1331	93	15	by	by	ADP
dti-1331	93	16	an	an	DET
dti-1331	93	17	increase	increase	NOUN
dti-1331	93	18	of	of	ADP
dti-1331	93	19	intracellular	intracellular	ADJ
dti-1331	93	20	calcium	calcium	NOUN
dti-1331	93	21	.	.	PUNCT
dti-1331	94	1	these	these	DET
dti-1331	94	2	events	event	NOUN
dti-1331	94	3	lead	lead	VERB
dti-1331	94	4	to	to	ADP
dti-1331	94	5	a	a	DET
dti-1331	94	6	second	second	ADJ
dti-1331	94	7	messenger	messenger	NOUN
dti-1331	94	8	activation	activation	NOUN
dti-1331	94	9	,	,	PUNCT
dti-1331	94	10	giving	give	VERB
dti-1331	94	11	rise	rise	NOUN
dti-1331	94	12	to	to	ADP
dti-1331	94	13	changes	change	NOUN
dti-1331	94	14	that	that	PRON
dti-1331	94	15	make	make	VERB
dti-1331	94	16	the	the	DET
dti-1331	94	17	cell	cell	NOUN
dti-1331	94	18	more	more	ADV
dti-1331	94	19	permeable	permeable	ADJ
dti-1331	94	20	to	to	ADP
dti-1331	94	21	additional	additional	ADJ
dti-1331	94	22	calcium	calcium	NOUN
dti-1331	94	23	entry	entry	NOUN
dti-1331	94	24	and	and	CCONJ
dti-1331	94	25	further	further	ADJ
dti-1331	94	26	glutamate	glutamate	NOUN
dti-1331	94	27	release	release	NOUN
dti-1331	94	28	.	.	PUNCT
dti-1331	95	1	glutamate	glutamate	ADJ
dti-1331	95	2	release	release	NOUN
dti-1331	95	3	also	also	ADV
dti-1331	95	4	gives	give	VERB
dti-1331	95	5	rise	rise	NOUN
dti-1331	95	6	to	to	ADP
dti-1331	95	7	oxygen	oxygen	VERB
dti-1331	95	8	free	free	ADJ
dti-1331	95	9	radical	radical	ADJ
dti-1331	95	10	production	production	NOUN
dti-1331	95	11	,	,	PUNCT
dti-1331	95	12	which	which	PRON
dti-1331	95	13	maintains	maintain	VERB
dti-1331	95	14	the	the	DET
dti-1331	95	15	further	further	ADJ
dti-1331	95	16	release	release	NOUN
dti-1331	95	17	of	of	ADP
dti-1331	95	18	glutamate	glutamate	NOUN
dti-1331	95	19	.	.	PUNCT
dti-1331	96	1	controversial	controversial	ADJ
dti-1331	96	2	are	be	AUX
dti-1331	96	3	the	the	DET
dti-1331	96	4	results	result	NOUN
dti-1331	96	5	from	from	ADP
dti-1331	96	6	animal	animal	NOUN
dti-1331	96	7	studies	study	NOUN
dti-1331	96	8	:	:	PUNCT
dti-1331	96	9	often	often	ADV
dti-1331	96	10	short	short	ADJ
dti-1331	96	11	delays	delay	NOUN
dti-1331	96	12	(	(	PUNCT
dti-1331	96	13	1–3	1–3	NUM
dti-1331	96	14	days	day	NOUN
dti-1331	96	15	)	)	PUNCT
dti-1331	96	16	for	for	ADP
dti-1331	96	17	analysis	analysis	NOUN
dti-1331	96	18	of	of	ADP
dti-1331	96	19	infarct	infarct	ADJ
dti-1331	96	20	size	size	NOUN
dti-1331	96	21	are	be	AUX
dti-1331	96	22	used	use	VERB
dti-1331	96	23	.	.	PUNCT
dti-1331	97	1	there	there	PRON
dti-1331	97	2	are	be	VERB
dti-1331	97	3	data	datum	NOUN
dti-1331	97	4	showing	show	VERB
dti-1331	97	5	that	that	SCONJ
dti-1331	97	6	some	some	DET
dti-1331	97	7	treatments	treatment	NOUN
dti-1331	97	8	delay	delay	VERB
dti-1331	97	9	,	,	PUNCT
dti-1331	97	10	but	but	CCONJ
dti-1331	97	11	do	do	AUX
dti-1331	97	12	not	not	PART
dti-1331	97	13	really	really	ADV
dti-1331	97	14	prevent	prevent	VERB
dti-1331	97	15	neuronal	neuronal	ADJ
dti-1331	97	16	death	death	NOUN
dti-1331	97	17	.	.	PUNCT
dti-1331	98	1	therefore	therefore	ADV
dti-1331	98	2	,	,	PUNCT
dti-1331	98	3	the	the	DET
dti-1331	98	4	protective	protective	ADJ
dti-1331	98	5	effects	effect	NOUN
dti-1331	98	6	are	be	AUX
dti-1331	98	7	seen	see	VERB
dti-1331	98	8	when	when	SCONJ
dti-1331	98	9	analyzed	analyze	VERB
dti-1331	98	10	at	at	ADP
dti-1331	98	11	three	three	NUM
dti-1331	98	12	days	day	NOUN
dti-1331	98	13	but	but	CCONJ
dti-1331	98	14	not	not	PART
dti-1331	98	15	7–28	7–28	ADJ
dti-1331	98	16	days	day	NOUN
dti-1331	98	17	after	after	ADP
dti-1331	98	18	insult	insult	NOUN
dti-1331	98	19	.	.	PUNCT
dti-1331	99	1	infarct	infarct	ADJ
dti-1331	99	2	volume	volume	NOUN
dti-1331	99	3	or	or	CCONJ
dti-1331	99	4	cell	cell	NOUN
dti-1331	99	5	damage	damage	NOUN
dti-1331	99	6	is	be	AUX
dti-1331	99	7	not	not	PART
dti-1331	99	8	always	always	ADV
dti-1331	99	9	predictive	predictive	ADJ
dti-1331	99	10	of	of	ADP
dti-1331	99	11	functional	functional	ADJ
dti-1331	99	12	outcome	outcome	NOUN
dti-1331	99	13	.	.	PUNCT
dti-1331	100	1	there	there	PRON
dti-1331	100	2	is	be	VERB
dti-1331	100	3	signifi	signifi	NOUN
dti-1331	100	4	ca	can	AUX
dti-1331	100	5	nt	not	PART
dti-1331	100	6	strain	strain	VERB
dti-1331	100	7	and	and	CCONJ
dti-1331	100	8	vendor	vendor	NOUN
dti-1331	100	9	variability	variability	NOUN
dti-1331	100	10	of	of	ADP
dti-1331	100	11	infarct	infarct	ADJ
dti-1331	100	12	size	size	NOUN
dti-1331	100	13	and	and	CCONJ
dti-1331	100	14	neuroprotective	neuroprotective	ADJ
dti-1331	100	15	efficacy	efficacy	NOUN
dti-1331	100	16	of	of	ADP
dti-1331	100	17	nmda	nmda	ADJ
dti-1331	100	18	receptor	receptor	NOUN
dti-1331	100	19	antagonists	antagonist	NOUN
dti-1331	100	20	,	,	PUNCT
dti-1331	100	21	adding	add	VERB
dti-1331	100	22	to	to	ADP
dti-1331	100	23	the	the	DET
dti-1331	100	24	already	already	ADV
dti-1331	100	25	large	large	ADJ
dti-1331	100	26	methodological	methodological	ADJ
dti-1331	100	27	diversity	diversity	NOUN
dti-1331	100	28	(	(	PUNCT
dti-1331	100	29	mortimer	mortimer	PROPN
dti-1331	100	30	et	et	PROPN
dti-1331	100	31	al	al	PROPN
dti-1331	100	32	.	.	PROPN
dti-1331	100	33	1991	1991	NUM
dti-1331	100	34	;	;	PUNCT
dti-1331	100	35	orgogozo	orgogozo	PROPN
dti-1331	100	36	et	et	PROPN
dti-1331	100	37	al	al	PROPN
dti-1331	100	38	.	.	PROPN
dti-1331	100	39	2002	2002	NUM
dti-1331	100	40	)	)	PUNCT
dti-1331	100	41	.	.	PUNCT
dti-1331	101	1	physiological	physiological	ADJ
dti-1331	101	2	nmda	nmda	ADJ
dti-1331	101	3	receptor	receptor	NOUN
dti-1331	101	4	activity	activity	NOUN
dti-1331	101	5	,	,	PUNCT
dti-1331	101	6	however	however	ADV
dti-1331	101	7	,	,	PUNCT
dti-1331	101	8	is	be	AUX
dti-1331	101	9	also	also	ADV
dti-1331	101	10	essential	essential	ADJ
dti-1331	101	11	for	for	ADP
dti-1331	101	12	normal	normal	ADJ
dti-1331	101	13	neuronal	neuronal	ADJ
dti-1331	101	14	function	function	NOUN
dti-1331	101	15	;	;	PUNCT
dti-1331	101	16	potential	potential	ADJ
dti-1331	101	17	neuroprotective	neuroprotective	ADJ
dti-1331	101	18	agents	agent	NOUN
dti-1331	101	19	that	that	PRON
dti-1331	101	20	block	block	VERB
dti-1331	101	21	virtually	virtually	ADV
dti-1331	101	22	all	all	DET
dti-1331	101	23	nmda	nmda	ADJ
dti-1331	101	24	receptor	receptor	NOUN
dti-1331	101	25	activity	activity	NOUN
dti-1331	101	26	will	will	AUX
dti-1331	101	27	very	very	ADV
dti-1331	101	28	likely	likely	ADV
dti-1331	101	29	have	have	VERB
dti-1331	101	30	unacceptable	unacceptable	ADJ
dti-1331	101	31	clinical	clinical	ADJ
dti-1331	101	32	side	side	NOUN
dti-1331	101	33	effects	effect	NOUN
dti-1331	101	34	.	.	PUNCT
dti-1331	102	1	for	for	ADP
dti-1331	102	2	this	this	DET
dti-1331	102	3	reason	reason	NOUN
dti-1331	102	4	many	many	ADJ
dti-1331	102	5	nmda	nmda	ADJ
dti-1331	102	6	receptor	receptor	NOUN
dti-1331	102	7	antagonists	antagonist	NOUN
dti-1331	102	8	have	have	AUX
dti-1331	102	9	disappointingly	disappointingly	ADV
dti-1331	102	10	failed	fail	VERB
dti-1331	102	11	advanced	advanced	ADJ
dti-1331	102	12	clinical	clinical	ADJ
dti-1331	102	13	trials	trial	NOUN
dti-1331	102	14	for	for	ADP
dti-1331	102	15	a	a	DET
dti-1331	102	16	number	number	NOUN
dti-1331	102	17	of	of	ADP
dti-1331	102	18	diseases	disease	NOUN
dti-1331	102	19	including	include	VERB
dti-1331	102	20	stroke	stroke	NOUN
dti-1331	102	21	and	and	CCONJ
dti-1331	102	22	neurodegenerative	neurodegenerative	ADJ
dti-1331	102	23	disorders	disorder	NOUN
dti-1331	102	24	such	such	ADJ
dti-1331	102	25	as	as	ADP
dti-1331	102	26	huntington	huntington	PROPN
dti-1331	102	27	’s	’s	PART
dti-1331	102	28	disease	disease	NOUN
dti-1331	102	29	.	.	PUNCT
dti-1331	103	1	in	in	ADP
dti-1331	103	2	contrast	contrast	NOUN
dti-1331	103	3	,	,	PUNCT
dti-1331	103	4	studies	study	NOUN
dti-1331	103	5	by	by	ADP
dti-1331	103	6	lipton	lipton	PROPN
dti-1331	103	7	(	(	PUNCT
dti-1331	103	8	2004	2004	NUM
dti-1331	103	9	)	)	PUNCT
dti-1331	103	10	were	be	AUX
dti-1331	103	11	the	the	DET
dti-1331	103	12	fi	fi	NOUN
dti-1331	103	13	rst	rst	NOUN
dti-1331	103	14	to	to	PART
dti-1331	103	15	show	show	VERB
dti-1331	103	16	that	that	PRON
dti-1331	103	17	memantine	memantine	NOUN
dti-1331	103	18	preferentially	preferentially	ADV
dti-1331	103	19	blocks	block	VERB
dti-1331	103	20	excessive	excessive	ADJ
dti-1331	103	21	nmda	nmda	ADJ
dti-1331	103	22	receptor	receptor	NOUN
dti-1331	103	23	activity	activity	NOUN
dti-1331	103	24	without	without	ADP
dti-1331	103	25	disrupting	disrupt	VERB
dti-1331	103	26	normal	normal	ADJ
dti-1331	103	27	activity	activity	NOUN
dti-1331	103	28	(	(	PUNCT
dti-1331	103	29	orgogozo	orgogozo	PROPN
dti-1331	103	30	et	et	PROPN
dti-1331	103	31	al	al	PROPN
dti-1331	103	32	.	.	PROPN
dti-1331	103	33	2002	2002	NUM
dti-1331	103	34	)	)	PUNCT
dti-1331	103	35	.	.	PUNCT
dti-1331	104	1	based	base	VERB
dti-1331	104	2	on	on	ADP
dti-1331	104	3	the	the	DET
dti-1331	104	4	hypothesis	hypothesis	NOUN
dti-1331	104	5	of	of	ADP
dti-1331	104	6	glutamate	glutamate	NOUN
dti-1331	104	7	-	-	PUNCT
dti-1331	104	8	induced	induce	VERB
dti-1331	104	9	neurotoxicity	neurotoxicity	NOUN
dti-1331	104	10	(	(	PUNCT
dti-1331	104	11	excitotoxicity	excitotoxicity	NOUN
dti-1331	104	12	)	)	PUNCT
dti-1331	104	13	in	in	ADP
dti-1331	104	14	cerebral	cerebral	ADJ
dti-1331	104	15	ischemia	ischemia	NOUN
dti-1331	104	16	,	,	PUNCT
dti-1331	104	17	different	different	ADJ
dti-1331	104	18	studies	study	NOUN
dti-1331	104	19	examined	examine	VERB
dti-1331	104	20	the	the	DET
dti-1331	104	21	effi	effi	PROPN
dti-1331	104	22	cacy	cacy	NOUN
dti-1331	104	23	and	and	CCONJ
dti-1331	104	24	tolerability	tolerability	NOUN
dti-1331	104	25	of	of	ADP
dti-1331	104	26	memantine	memantine	NOUN
dti-1331	104	27	,	,	PUNCT
dti-1331	104	28	an	an	DET
dti-1331	104	29	uncompetitive	uncompetitive	ADJ
dti-1331	104	30	n	n	CCONJ
dti-1331	104	31	-	-	PUNCT
dti-1331	104	32	methyld	methyld	NOUN
dti-1331	104	33	-	-	PUNCT
dti-1331	104	34	aspartate	aspartate	NOUN
dti-1331	104	35	antagonist	antagonist	NOUN
dti-1331	104	36	,	,	PUNCT
dti-1331	104	37	in	in	ADP
dti-1331	104	38	the	the	DET
dti-1331	104	39	treatment	treatment	NOUN
dti-1331	104	40	of	of	ADP
dti-1331	104	41	mild	mild	ADJ
dti-1331	104	42	to	to	ADP
dti-1331	104	43	moderate	moderate	ADJ
dti-1331	104	44	vascular	vascular	ADJ
dti-1331	104	45	dementia	dementia	NOUN
dti-1331	104	46	.	.	PUNCT
dti-1331	105	1	in	in	ADP
dti-1331	105	2	a	a	DET
dti-1331	105	3	multicenter	multicenter	NOUN
dti-1331	105	4	,	,	PUNCT
dti-1331	105	5	28	28	NUM
dti-1331	105	6	-	-	PUNCT
dti-1331	105	7	week	week	NOUN
dti-1331	105	8	trial	trial	NOUN
dti-1331	105	9	carried	carry	VERB
dti-1331	105	10	out	out	ADP
dti-1331	105	11	in	in	ADP
dti-1331	105	12	france	france	PROPN
dti-1331	105	13	,	,	PUNCT
dti-1331	105	14	321	321	NUM
dti-1331	105	15	patients	patient	NOUN
dti-1331	105	16	received	receive	VERB
dti-1331	105	17	10	10	NUM
dti-1331	105	18	mg	mg	NUM
dti-1331	105	19	/	/	SYM
dti-1331	105	20	d	d	NOUN
dti-1331	105	21	memantine	memantine	NOUN
dti-1331	105	22	or	or	CCONJ
dti-1331	105	23	placebo	placebo	NOUN
dti-1331	105	24	twice	twice	ADV
dti-1331	105	25	a	a	DET
dti-1331	105	26	day	day	NOUN
dti-1331	105	27	;	;	PUNCT
dti-1331	105	28	288	288	NUM
dti-1331	105	29	patients	patient	NOUN
dti-1331	105	30	were	be	AUX
dti-1331	105	31	valid	valid	ADJ
dti-1331	105	32	for	for	ADP
dti-1331	105	33	intent	intent	NOUN
dti-1331	105	34	-	-	PUNCT
dti-1331	105	35	to	to	AUX
dti-1331	105	36	-	-	PUNCT
dti-1331	105	37	treat	treat	VERB
dti-1331	105	38	analysis	analysis	NOUN
dti-1331	105	39	.	.	PUNCT
dti-1331	106	1	patients	patient	NOUN
dti-1331	106	2	had	have	VERB
dti-1331	106	3	to	to	PART
dti-1331	106	4	meet	meet	VERB
dti-1331	106	5	the	the	DET
dti-1331	106	6	criteria	criterion	NOUN
dti-1331	106	7	for	for	ADP
dti-1331	106	8	probable	probable	ADJ
dti-1331	106	9	vascular	vascular	ADJ
dti-1331	106	10	dementia	dementia	NOUN
dti-1331	106	11	and	and	CCONJ
dti-1331	106	12	have	have	VERB
dti-1331	106	13	a	a	DET
dti-1331	106	14	mini	mini	ADJ
dti-1331	106	15	-	-	ADJ
dti-1331	106	16	mental	mental	ADJ
dti-1331	106	17	state	state	NOUN
dti-1331	106	18	(	(	PUNCT
dti-1331	106	19	mmse	mmse	ADJ
dti-1331	106	20	)	)	PUNCT
dti-1331	106	21	score	score	NOUN
dti-1331	106	22	between	between	ADP
dti-1331	106	23	12	12	NUM
dti-1331	106	24	and	and	CCONJ
dti-1331	106	25	20	20	NUM
dti-1331	106	26	at	at	ADP
dti-1331	106	27	inclusion	inclusion	NOUN
dti-1331	106	28	.	.	PUNCT
dti-1331	107	1	the	the	DET
dti-1331	107	2	2	2	NUM
dti-1331	107	3	primary	primary	ADJ
dti-1331	107	4	end	end	NOUN
dti-1331	107	5	points	point	NOUN
dti-1331	107	6	were	be	AUX
dti-1331	107	7	the	the	DET
dti-1331	107	8	cognitive	cognitive	ADJ
dti-1331	107	9	subscale	subscale	NOUN
dti-1331	107	10	of	of	ADP
dti-1331	107	11	the	the	DET
dti-1331	107	12	alzheimers	alzheimers	PROPN
dti-1331	107	13	disease	disease	NOUN
dti-1331	107	14	assessment	assessment	NOUN
dti-1331	107	15	scale	scale	NOUN
dti-1331	107	16	(	(	PUNCT
dti-1331	107	17	adas	adas	PROPN
dti-1331	107	18	-	-	PUNCT
dti-1331	107	19	cog	cog	PROPN
dti-1331	107	20	)	)	PUNCT
dti-1331	107	21	and	and	CCONJ
dti-1331	107	22	the	the	DET
dti-1331	107	23	global	global	ADJ
dti-1331	107	24	clinician	clinician	NOUN
dti-1331	107	25	’s	’s	PART
dti-1331	107	26	interview	interview	NOUN
dti-1331	107	27	based	base	VERB
dti-1331	107	28	impression	impression	NOUN
dti-1331	107	29	of	of	ADP
dti-1331	107	30	change	change	NOUN
dti-1331	107	31	(	(	PUNCT
dti-1331	107	32	cibic	cibic	NOUN
dti-1331	107	33	-	-	PUNCT
dti-1331	107	34	plus	plus	NOUN
dti-1331	107	35	)	)	PUNCT
dti-1331	107	36	(	(	PUNCT
dti-1331	107	37	wilkock	wilkock	NOUN
dti-1331	107	38	et	et	PROPN
dti-1331	107	39	al	al	PROPN
dti-1331	107	40	.	.	PROPN
dti-1331	107	41	2002	2002	NUM
dti-1331	107	42	)	)	PUNCT
dti-1331	107	43	.	.	PUNCT
dti-1331	108	1	after	after	ADP
dti-1331	108	2	28	28	NUM
dti-1331	108	3	weeks	week	NOUN
dti-1331	108	4	,	,	PUNCT
dti-1331	108	5	the	the	DET
dti-1331	108	6	mean	mean	ADJ
dti-1331	108	7	adas	adas	PROPN
dti-1331	108	8	-	-	PUNCT
dti-1331	108	9	cog	cog	PROPN
dti-1331	108	10	scores	score	NOUN
dti-1331	108	11	were	be	AUX
dti-1331	108	12	signifi	signifi	NOUN
dti-1331	108	13	cantly	cantly	ADV
dti-1331	108	14	improved	improve	VERB
dti-1331	108	15	relative	relative	ADJ
dti-1331	108	16	to	to	ADP
dti-1331	108	17	placebo	placebo	NOUN
dti-1331	108	18	.	.	PUNCT
dti-1331	109	1	in	in	ADP
dti-1331	109	2	the	the	DET
dti-1331	109	3	intention	intention	NOUN
dti-1331	109	4	-	-	PUNCT
dti-1331	109	5	to	to	ADP
dti-1331	109	6	-	-	PUNCT
dti-1331	109	7	treat	treat	VERB
dti-1331	109	8	population	population	NOUN
dti-1331	109	9	,	,	PUNCT
dti-1331	109	10	the	the	DET
dti-1331	109	11	memantine	memantine	NOUN
dti-1331	109	12	group	group	NOUN
dti-1331	109	13	mean	mean	NOUN
dti-1331	109	14	score	score	NOUN
dti-1331	109	15	had	have	AUX
dti-1331	109	16	gained	gain	VERB
dti-1331	109	17	an	an	DET
dti-1331	109	18	average	average	NOUN
dti-1331	109	19	of	of	ADP
dti-1331	109	20	0.4	0.4	NUM
dti-1331	109	21	points	point	NOUN
dti-1331	109	22	,	,	PUNCT
dti-1331	109	23	whereas	whereas	SCONJ
dti-1331	109	24	the	the	DET
dti-1331	109	25	placebo	placebo	NOUN
dti-1331	109	26	group	group	NOUN
dti-1331	109	27	mean	mean	NOUN
dti-1331	109	28	score	score	NOUN
dti-1331	109	29	had	have	AUX
dti-1331	109	30	declined	decline	VERB
dti-1331	109	31	by	by	ADP
dti-1331	109	32	1.6	1.6	NUM
dti-1331	109	33	points	point	NOUN
dti-1331	109	34	(	(	PUNCT
dti-1331	109	35	95	95	NUM
dti-1331	109	36	%	%	NOUN
dti-1331	109	37	confi	confi	NOUN
dti-1331	109	38	dence	dence	NOUN
dti-1331	109	39	interval	interval	NOUN
dti-1331	109	40	,	,	PUNCT
dti-1331	109	41	0.49	0.49	NUM
dti-1331	109	42	to	to	ADP
dti-1331	109	43	3.60	3.60	NUM
dti-1331	109	44	)	)	PUNCT
dti-1331	109	45	.	.	PUNCT
dti-1331	110	1	the	the	DET
dti-1331	110	2	response	response	NOUN
dti-1331	110	3	rate	rate	NOUN
dti-1331	110	4	for	for	ADP
dti-1331	110	5	cibic	cibic	NOUN
dti-1331	110	6	-	-	PUNCT
dti-1331	110	7	plus	plus	NOUN
dti-1331	110	8	,	,	PUNCT
dti-1331	110	9	defi	defi	NOUN
dti-1331	110	10	ned	ned	PROPN
dti-1331	110	11	as	as	SCONJ
dti-1331	110	12	improved	improved	ADJ
dti-1331	110	13	or	or	CCONJ
dti-1331	110	14	stable	stable	ADJ
dti-1331	110	15	,	,	PUNCT
dti-1331	110	16	was	be	AUX
dti-1331	110	17	60	60	NUM
dti-1331	110	18	%	%	NOUN
dti-1331	110	19	with	with	ADP
dti-1331	110	20	memantine	memantine	NOUN
dti-1331	110	21	compared	compare	VERB
dti-1331	110	22	with	with	ADP
dti-1331	110	23	52	52	NUM
dti-1331	110	24	%	%	NOUN
dti-1331	110	25	with	with	ADP
dti-1331	110	26	placebo	placebo	NOUN
dti-1331	110	27	(	(	PUNCT
dti-1331	110	28	p	p	X
dti-1331	110	29	=	=	NOUN
dti-1331	110	30	0.227	0.227	NUM
dti-1331	110	31	,	,	PUNCT
dti-1331	110	32	intention	intention	NOUN
dti-1331	110	33	to	to	PART
dti-1331	110	34	treat	treat	VERB
dti-1331	110	35	)	)	PUNCT
dti-1331	110	36	.	.	PUNCT
dti-1331	111	1	among	among	ADP
dti-1331	111	2	the	the	DET
dti-1331	111	3	secondary	secondary	ADJ
dti-1331	111	4	effi	effi	PROPN
dti-1331	111	5	cacy	cacy	NOUN
dti-1331	111	6	parameters	parameter	NOUN
dti-1331	111	7	,	,	PUNCT
dti-1331	111	8	which	which	PRON
dti-1331	111	9	were	be	AUX
dti-1331	111	10	analyzed	analyze	VERB
dti-1331	111	11	in	in	ADP
dti-1331	111	12	the	the	DET
dti-1331	111	13	per	per	ADP
dti-1331	111	14	-	-	PUNCT
dti-1331	111	15	protocol	protocol	NOUN
dti-1331	111	16	subset	subset	NOUN
dti-1331	111	17	,	,	PUNCT
dti-1331	111	18	mmse	mmse	PROPN
dti-1331	111	19	was	be	AUX
dti-1331	111	20	signifi	signifi	NOUN
dti-1331	111	21	cantly	cantly	ADV
dti-1331	111	22	improved	improve	VERB
dti-1331	111	23	with	with	ADP
dti-1331	111	24	memantine	memantine	NOUN
dti-1331	111	25	compared	compare	VERB
dti-1331	111	26	with	with	ADP
dti-1331	111	27	deterioration	deterioration	NOUN
dti-1331	111	28	with	with	ADP
dti-1331	111	29	placebo	placebo	NOUN
dti-1331	111	30	(	(	PUNCT
dti-1331	111	31	p	p	X
dti-1331	111	32	=	=	NOUN
dti-1331	111	33	0.003	0.003	NUM
dti-1331	111	34	)	)	PUNCT
dti-1331	111	35	(	(	PUNCT
dti-1331	111	36	wilkock	wilkock	NOUN
dti-1331	111	37	et	et	PROPN
dti-1331	111	38	al	al	PROPN
dti-1331	111	39	.	.	PROPN
dti-1331	111	40	2002	2002	NUM
dti-1331	111	41	)	)	PUNCT
dti-1331	111	42	.	.	PUNCT
dti-1331	112	1	another	another	DET
dti-1331	112	2	work	work	NOUN
dti-1331	112	3	has	have	AUX
dti-1331	112	4	been	be	AUX
dti-1331	112	5	conducted	conduct	VERB
dti-1331	112	6	on	on	ADP
dti-1331	112	7	the	the	DET
dti-1331	112	8	topic	topic	NOUN
dti-1331	112	9	.	.	PUNCT
dti-1331	113	1	the	the	DET
dti-1331	113	2	aim	aim	NOUN
dti-1331	113	3	of	of	ADP
dti-1331	113	4	the	the	DET
dti-1331	113	5	reported	report	VERB
dti-1331	113	6	trial	trial	NOUN
dti-1331	113	7	was	be	AUX
dti-1331	113	8	to	to	PART
dti-1331	113	9	investigate	investigate	VERB
dti-1331	113	10	the	the	DET
dti-1331	113	11	safety	safety	NOUN
dti-1331	113	12	and	and	CCONJ
dti-1331	113	13	effi	effi	PROPN
dti-1331	113	14	cacy	cacy	NOUN
dti-1331	113	15	of	of	ADP
dti-1331	113	16	memantine	memantine	NOUN
dti-1331	113	17	in	in	ADP
dti-1331	113	18	mild	mild	ADJ
dti-1331	113	19	to	to	ADP
dti-1331	113	20	moderate	moderate	ADJ
dti-1331	113	21	vascular	vascular	ADJ
dti-1331	113	22	dementia	dementia	NOUN
dti-1331	113	23	(	(	PUNCT
dti-1331	113	24	vad	vad	PROPN
dti-1331	113	25	)	)	PUNCT
dti-1331	113	26	(	(	PUNCT
dti-1331	113	27	jarvis	jarvis	PROPN
dti-1331	113	28	et	et	PROPN
dti-1331	113	29	al	al	PROPN
dti-1331	113	30	.	.	PROPN
dti-1331	113	31	2002	2002	NUM
dti-1331	113	32	)	)	PUNCT
dti-1331	113	33	.	.	PUNCT
dti-1331	114	1	81	81	NUM
dti-1331	114	2	memantine	memantine	NOUN
dti-1331	114	3	:	:	PUNCT
dti-1331	114	4	reality	reality	NOUN
dti-1331	114	5	and	and	CCONJ
dti-1331	114	6	potentiality	potentiality	NOUN
dti-1331	114	7	drug	drug	NOUN
dti-1331	114	8	target	target	NOUN
dti-1331	114	9	insights	insight	NOUN
dti-1331	114	10	2008:3	2008:3	NUM
dti-1331	115	1	it	it	PRON
dti-1331	115	2	was	be	AUX
dti-1331	115	3	a	a	PRON
dti-1331	115	4	28	28	NUM
dti-1331	115	5	-	-	PUNCT
dti-1331	115	6	week	week	NOUN
dti-1331	115	7	,	,	PUNCT
dti-1331	115	8	double	double	ADJ
dti-1331	115	9	-	-	PUNCT
dti-1331	115	10	blind	blind	ADJ
dti-1331	115	11	,	,	PUNCT
dti-1331	115	12	parallel	parallel	ADJ
dti-1331	115	13	,	,	PUNCT
dti-1331	115	14	randomized	randomize	VERB
dti-1331	115	15	controlled	control	VERB
dti-1331	115	16	trial	trial	NOUN
dti-1331	115	17	of	of	ADP
dti-1331	115	18	memantine	memantine	NOUN
dti-1331	115	19	20	20	NUM
dti-1331	115	20	mg	mg	NOUN
dti-1331	115	21	daily	daily	ADV
dti-1331	115	22	versus	versus	ADP
dti-1331	115	23	placebo	placebo	NOUN
dti-1331	115	24	,	,	PUNCT
dti-1331	115	25	in	in	ADP
dti-1331	115	26	probable	probable	ADJ
dti-1331	115	27	vad	vad	X
dti-1331	115	28	which	which	PRON
dti-1331	115	29	was	be	AUX
dti-1331	115	30	conducted	conduct	VERB
dti-1331	115	31	in	in	ADP
dti-1331	115	32	54	54	NUM
dti-1331	115	33	centres	centre	NOUN
dti-1331	115	34	in	in	ADP
dti-1331	115	35	the	the	DET
dti-1331	115	36	u.k	u.k	PROPN
dti-1331	115	37	.	.	PROPN
dti-1331	115	38	primary	primary	PROPN
dti-1331	115	39	effi	effi	PROPN
dti-1331	115	40	cacy	cacy	PROPN
dti-1331	115	41	parameters	parameter	NOUN
dti-1331	115	42	were	be	AUX
dti-1331	115	43	cognition	cognition	NOUN
dti-1331	115	44	and	and	CCONJ
dti-1331	115	45	the	the	DET
dti-1331	115	46	clinical	clinical	ADJ
dti-1331	115	47	global	global	ADJ
dti-1331	115	48	impression	impression	NOUN
dti-1331	115	49	.	.	PUNCT
dti-1331	116	1	a	a	DET
dti-1331	116	2	total	total	NOUN
dti-1331	116	3	of	of	ADP
dti-1331	116	4	579	579	NUM
dti-1331	116	5	patients	patient	NOUN
dti-1331	116	6	were	be	AUX
dti-1331	116	7	randomized	randomize	VERB
dti-1331	116	8	and	and	CCONJ
dti-1331	116	9	548	548	NUM
dti-1331	116	10	patients	patient	NOUN
dti-1331	116	11	with	with	ADP
dti-1331	116	12	at	at	ADV
dti-1331	116	13	least	least	ADV
dti-1331	116	14	one	one	NUM
dti-1331	116	15	post	post	NOUN
dti-1331	116	16	baseline	baseline	PROPN
dti-1331	116	17	effi	effi	PROPN
dti-1331	116	18	cacy	cacy	PROPN
dti-1331	116	19	assessment	assessment	NOUN
dti-1331	116	20	qualifi	qualifi	PROPN
dti-1331	116	21	ed	ed	NOUN
dti-1331	116	22	for	for	ADP
dti-1331	116	23	the	the	DET
dti-1331	116	24	intent	intent	NOUN
dti-1331	116	25	-	-	PUNCT
dti-1331	116	26	to	to	AUX
dti-1331	116	27	-	-	PUNCT
dti-1331	116	28	treat	treat	VERB
dti-1331	116	29	analysis	analysis	NOUN
dti-1331	116	30	.	.	PUNCT
dti-1331	117	1	at	at	ADP
dti-1331	117	2	endpoint	endpoint	NOUN
dti-1331	117	3	,	,	PUNCT
dti-1331	117	4	memantine	memantine	NOUN
dti-1331	117	5	was	be	AUX
dti-1331	117	6	shown	show	VERB
dti-1331	117	7	to	to	PART
dti-1331	117	8	improve	improve	VERB
dti-1331	117	9	cognition	cognition	NOUN
dti-1331	117	10	relative	relative	ADJ
dti-1331	117	11	to	to	ADP
dti-1331	117	12	placebo	placebo	NOUN
dti-1331	117	13	in	in	ADP
dti-1331	117	14	vad	vad	PROPN
dti-1331	117	15	:	:	PUNCT
dti-1331	117	16	the	the	DET
dti-1331	117	17	change	change	NOUN
dti-1331	117	18	of	of	ADP
dti-1331	117	19	cognition	cognition	NOUN
dti-1331	117	20	scores	score	NOUN
dti-1331	117	21	from	from	ADP
dti-1331	117	22	baseline	baseline	PROPN
dti-1331	117	23	differed	differ	VERB
dti-1331	117	24	by	by	ADP
dti-1331	117	25	a	a	DET
dti-1331	117	26	mean	mean	NOUN
dti-1331	117	27	of	of	ADP
dti-1331	117	28	−1.75	−1.75	PROPN
dti-1331	117	29	points	point	NOUN
dti-1331	117	30	(	(	PUNCT
dti-1331	117	31	95	95	NUM
dti-1331	117	32	%	%	NOUN
dti-1331	117	33	confi	confi	NOUN
dti-1331	117	34	dence	dence	NOUN
dti-1331	117	35	intervals	interval	NOUN
dti-1331	117	36	−3.023	−3.023	NOUN
dti-1331	117	37	to	to	ADP
dti-1331	117	38	−0.49	−0.49	ADV
dti-1331	117	39	)	)	PUNCT
dti-1331	117	40	and	and	CCONJ
dti-1331	117	41	a	a	DET
dti-1331	117	42	median	median	NOUN
dti-1331	117	43	of	of	ADP
dti-1331	117	44	2	2	NUM
dti-1331	117	45	points	point	NOUN
dti-1331	117	46	between	between	ADP
dti-1331	117	47	the	the	DET
dti-1331	117	48	two	two	NUM
dti-1331	117	49	groups	group	NOUN
dti-1331	117	50	,	,	PUNCT
dti-1331	117	51	while	while	SCONJ
dti-1331	117	52	clinical	clinical	ADJ
dti-1331	117	53	general	general	ADJ
dti-1331	117	54	impression	impression	NOUN
dti-1331	117	55	on	on	ADP
dti-1331	117	56	the	the	DET
dti-1331	117	57	global	global	ADJ
dti-1331	117	58	status	status	NOUN
dti-1331	117	59	rating	rating	NOUN
dti-1331	117	60	scores	score	NOUN
dti-1331	117	61	showed	show	VERB
dti-1331	117	62	no	no	DET
dti-1331	117	63	signifi	signifi	NOUN
dti-1331	117	64	ca	can	AUX
dti-1331	117	65	nt	not	PART
dti-1331	117	66	differences	difference	NOUN
dti-1331	117	67	between	between	ADP
dti-1331	117	68	treatment	treatment	NOUN
dti-1331	117	69	groups	group	NOUN
dti-1331	117	70	.	.	PUNCT
dti-1331	118	1	demaerschalk	demaerschalk	NOUN
dti-1331	118	2	and	and	CCONJ
dti-1331	118	3	wingerchuk	wingerchuk	ADJ
dti-1331	118	4	(	(	PUNCT
dti-1331	118	5	2007	2007	NUM
dti-1331	118	6	)	)	PUNCT
dti-1331	118	7	examined	examine	VERB
dti-1331	118	8	in	in	ADP
dti-1331	118	9	a	a	DET
dti-1331	118	10	complete	complete	ADJ
dti-1331	118	11	meta	meta	ADJ
dti-1331	118	12	-	-	PUNCT
dti-1331	118	13	analysis	analysis	NOUN
dti-1331	118	14	eight	eight	NUM
dti-1331	118	15	relevant	relevant	ADJ
dti-1331	118	16	systematic	systematic	ADJ
dti-1331	118	17	reviews	review	NOUN
dti-1331	118	18	and	and	CCONJ
dti-1331	118	19	randomized	randomize	VERB
dti-1331	118	20	controlled	control	VERB
dti-1331	118	21	trials	trial	NOUN
dti-1331	118	22	were	be	AUX
dti-1331	118	23	identifi	identifi	PROPN
dti-1331	118	24	ed	ed	NOUN
dti-1331	118	25	and	and	CCONJ
dti-1331	118	26	served	serve	VERB
dti-1331	118	27	as	as	ADP
dti-1331	118	28	the	the	DET
dti-1331	118	29	principal	principal	ADJ
dti-1331	118	30	sources	source	NOUN
dti-1331	118	31	of	of	ADP
dti-1331	118	32	information	information	NOUN
dti-1331	118	33	.	.	PUNCT
dti-1331	119	1	the	the	DET
dti-1331	119	2	best	good	ADJ
dti-1331	119	3	evidence	evidence	NOUN
dti-1331	119	4	to	to	ADP
dti-1331	119	5	date	date	NOUN
dti-1331	119	6	revealed	reveal	VERB
dti-1331	119	7	that	that	SCONJ
dti-1331	119	8	donepezil	donepezil	NOUN
dti-1331	119	9	5	5	NUM
dti-1331	119	10	mg	mg	NOUN
dti-1331	119	11	/	/	SYM
dti-1331	119	12	d	d	NOUN
dti-1331	120	1	[	[	X
dti-1331	120	2	number	number	NOUN
dti-1331	120	3	needed	need	VERB
dti-1331	120	4	to	to	PART
dti-1331	120	5	treat	treat	VERB
dti-1331	120	6	(	(	PUNCT
dti-1331	120	7	nnt	nnt	X
dti-1331	120	8	)	)	PUNCT
dti-1331	120	9	=	=	SYM
dti-1331	120	10	10	10	NUM
dti-1331	120	11	]	]	PUNCT
dti-1331	120	12	was	be	AUX
dti-1331	120	13	the	the	DET
dti-1331	120	14	most	most	ADV
dti-1331	120	15	effective	effective	ADJ
dti-1331	120	16	and	and	CCONJ
dti-1331	120	17	best	well	ADV
dti-1331	120	18	tolerated	tolerate	VERB
dti-1331	120	19	[	[	PUNCT
dti-1331	120	20	number	number	NOUN
dti-1331	120	21	needed	need	VERB
dti-1331	120	22	to	to	PART
dti-1331	120	23	harm	harm	VERB
dti-1331	120	24	(	(	PUNCT
dti-1331	120	25	nnh	nnh	ADJ
dti-1331	120	26	)	)	PUNCT
dti-1331	120	27	=	=	SYM
dti-1331	120	28	50	50	NUM
dti-1331	120	29	]	]	PUNCT
dti-1331	120	30	of	of	ADP
dti-1331	120	31	the	the	DET
dti-1331	120	32	available	available	ADJ
dti-1331	120	33	agents	agent	NOUN
dti-1331	120	34	.	.	PUNCT
dti-1331	121	1	galantamine	galantamine	NOUN
dti-1331	121	2	24	24	NUM
dti-1331	121	3	mg	mg	PROPN
dti-1331	121	4	/	/	SYM
dti-1331	121	5	d	d	PROPN
dti-1331	121	6	(	(	PUNCT
dti-1331	121	7	nnt	nnt	X
dti-1331	121	8	=	=	SYM
dti-1331	121	9	7	7	X
dti-1331	121	10	)	)	PUNCT
dti-1331	121	11	was	be	AUX
dti-1331	121	12	also	also	ADV
dti-1331	121	13	effective	effective	ADJ
dti-1331	121	14	but	but	CCONJ
dti-1331	121	15	less	less	ADV
dti-1331	121	16	well	well	ADV
dti-1331	121	17	tolerated	tolerate	VERB
dti-1331	121	18	(	(	PUNCT
dti-1331	121	19	nnh	nnh	NOUN
dti-1331	121	20	=	=	NOUN
dti-1331	121	21	7	7	NUM
dti-1331	121	22	)	)	PUNCT
dti-1331	121	23	.	.	PUNCT
dti-1331	122	1	due	due	ADP
dti-1331	122	2	to	to	ADP
dti-1331	122	3	insuffi	insuffi	PROPN
dti-1331	122	4	cient	cient	NOUN
dti-1331	122	5	evidence	evidence	NOUN
dti-1331	122	6	,	,	PUNCT
dti-1331	122	7	rivastigmine	rivastigmine	PROPN
dti-1331	122	8	could	could	AUX
dti-1331	122	9	not	not	PART
dti-1331	122	10	yet	yet	ADV
dti-1331	122	11	be	be	AUX
dti-1331	122	12	recommended	recommend	VERB
dti-1331	122	13	for	for	ADP
dti-1331	122	14	the	the	DET
dti-1331	122	15	treatment	treatment	NOUN
dti-1331	122	16	of	of	ADP
dti-1331	122	17	vascular	vascular	ADJ
dti-1331	122	18	dementia	dementia	NOUN
dti-1331	122	19	.	.	PUNCT
dti-1331	123	1	memantine	memantine	PROPN
dti-1331	123	2	appeared	appear	VERB
dti-1331	123	3	to	to	PART
dti-1331	123	4	be	be	AUX
dti-1331	123	5	safe	safe	ADJ
dti-1331	123	6	and	and	CCONJ
dti-1331	123	7	well	well	ADV
dti-1331	123	8	tolerated	tolerate	VERB
dti-1331	123	9	but	but	CCONJ
dti-1331	123	10	did	do	AUX
dti-1331	123	11	not	not	PART
dti-1331	123	12	demonstrate	demonstrate	VERB
dti-1331	123	13	effectiveness	effectiveness	NOUN
dti-1331	123	14	across	across	ADP
dti-1331	123	15	all	all	DET
dti-1331	123	16	cognitive	cognitive	ADJ
dti-1331	123	17	outcomes	outcome	NOUN
dti-1331	123	18	and	and	CCONJ
dti-1331	123	19	clinical	clinical	ADJ
dti-1331	123	20	global	global	ADJ
dti-1331	123	21	measures	measure	NOUN
dti-1331	123	22	.	.	PUNCT
dti-1331	124	1	acetylcholinesterase	acetylcholinesterase	VERB
dti-1331	124	2	inhibitors	inhibitor	NOUN
dti-1331	124	3	and	and	CCONJ
dti-1331	124	4	nmda	nmda	ADJ
dti-1331	124	5	receptor	receptor	NOUN
dti-1331	124	6	antagonists	antagonist	NOUN
dti-1331	124	7	,	,	PUNCT
dti-1331	124	8	in	in	ADP
dti-1331	124	9	general	general	ADJ
dti-1331	124	10	,	,	PUNCT
dti-1331	124	11	displayed	display	VERB
dti-1331	124	12	promise	promise	NOUN
dti-1331	124	13	as	as	ADP
dti-1331	124	14	treatments	treatment	NOUN
dti-1331	124	15	for	for	ADP
dti-1331	124	16	patients	patient	NOUN
dti-1331	124	17	with	with	ADP
dti-1331	124	18	vascular	vascular	ADJ
dti-1331	124	19	dementia	dementia	NOUN
dti-1331	124	20	and	and	CCONJ
dti-1331	124	21	vascular	vascular	ADJ
dti-1331	124	22	cognitive	cognitive	ADJ
dti-1331	124	23	impairment	impairment	NOUN
dti-1331	124	24	.	.	PUNCT
dti-1331	125	1	the	the	DET
dti-1331	125	2	most	most	ADV
dti-1331	125	3	effective	effective	ADJ
dti-1331	125	4	,	,	PUNCT
dti-1331	125	5	evidence	evidence	NOUN
dti-1331	125	6	-	-	PUNCT
dti-1331	125	7	based	base	VERB
dti-1331	125	8	treatments	treatment	NOUN
dti-1331	125	9	were	be	AUX
dti-1331	125	10	donepezil	donepezil	NOUN
dti-1331	125	11	and	and	CCONJ
dti-1331	125	12	galantamine	galantamine	VERB
dti-1331	125	13	memantine	memantine	NOUN
dti-1331	125	14	and	and	CCONJ
dti-1331	125	15	parkinson	parkinson	NOUN
dti-1331	125	16	’s	’s	PART
dti-1331	125	17	disease	disease	NOUN
dti-1331	125	18	because	because	SCONJ
dti-1331	125	19	of	of	ADP
dti-1331	125	20	its	its	PRON
dti-1331	125	21	peculiar	peculiar	ADJ
dti-1331	125	22	pharmacological	pharmacological	ADJ
dti-1331	125	23	properties	property	NOUN
dti-1331	125	24	,	,	PUNCT
dti-1331	125	25	memantine	memantine	NOUN
dti-1331	125	26	is	be	AUX
dti-1331	125	27	proposed	propose	VERB
dti-1331	125	28	to	to	PART
dti-1331	125	29	be	be	AUX
dti-1331	125	30	benefi	benefi	PROPN
dti-1331	125	31	cial	cial	NOUN
dti-1331	125	32	,	,	PUNCT
dti-1331	125	33	as	as	SCONJ
dti-1331	125	34	it	it	PRON
dti-1331	125	35	blocks	block	VERB
dti-1331	125	36	excessive	excessive	ADJ
dti-1331	125	37	nmda	nmda	ADJ
dti-1331	125	38	receptors	receptor	NOUN
dti-1331	125	39	activation	activation	NOUN
dti-1331	125	40	,	,	PUNCT
dti-1331	125	41	without	without	ADP
dti-1331	125	42	interfering	interfere	VERB
dti-1331	125	43	with	with	ADP
dti-1331	125	44	their	their	PRON
dti-1331	125	45	physiological	physiological	ADJ
dti-1331	125	46	activity	activity	NOUN
dti-1331	125	47	.	.	PUNCT
dti-1331	126	1	an	an	DET
dti-1331	126	2	anti	anti	ADJ
dti-1331	126	3	-	-	ADJ
dti-1331	126	4	parkinsonian	parkinsonian	ADJ
dti-1331	126	5	activity	activity	NOUN
dti-1331	126	6	has	have	AUX
dti-1331	126	7	been	be	AUX
dti-1331	126	8	described	describe	VERB
dti-1331	126	9	for	for	ADP
dti-1331	126	10	memantine	memantine	NOUN
dti-1331	126	11	,	,	PUNCT
dti-1331	126	12	in	in	ADP
dti-1331	126	13	animal	animal	NOUN
dti-1331	126	14	models	model	NOUN
dti-1331	126	15	of	of	ADP
dti-1331	126	16	parkinson	parkinson	NOUN
dti-1331	126	17	’s	’s	PART
dti-1331	126	18	disease	disease	NOUN
dti-1331	126	19	and	and	CCONJ
dti-1331	126	20	in	in	ADP
dti-1331	126	21	parkinsonian	parkinsonian	ADJ
dti-1331	126	22	patients	patient	NOUN
dti-1331	126	23	(	(	PUNCT
dti-1331	126	24	merello	merello	NOUN
dti-1331	126	25	et	et	PROPN
dti-1331	126	26	al	al	PROPN
dti-1331	126	27	.	.	PROPN
dti-1331	126	28	1999	1999	NUM
dti-1331	126	29	)	)	PUNCT
dti-1331	126	30	.	.	PUNCT
dti-1331	127	1	in	in	ADP
dti-1331	127	2	addition	addition	NOUN
dti-1331	127	3	,	,	PUNCT
dti-1331	127	4	memantine	memantine	NOUN
dti-1331	127	5	prevents	prevent	VERB
dti-1331	127	6	cell	cell	NOUN
dti-1331	127	7	death	death	NOUN
dti-1331	127	8	induced	induce	VERB
dti-1331	127	9	by	by	ADP
dti-1331	127	10	1	1	NUM
dti-1331	127	11	-	-	PUNCT
dti-1331	127	12	methyl-4	methyl-4	NOUN
dti-1331	127	13	-	-	PUNCT
dti-1331	127	14	phenyl1,2,3,6tetrahydropyridine	phenyl1,2,3,6tetrahydropyridine	NOUN
dti-1331	127	15	(	(	PUNCT
dti-1331	127	16	kucheryanu	kucheryanu	NOUN
dti-1331	127	17	and	and	CCONJ
dti-1331	127	18	kryzhanovskii	kryzhanovskii	ADJ
dti-1331	127	19	,	,	PUNCT
dti-1331	127	20	2000	2000	NUM
dti-1331	127	21	)	)	PUNCT
dti-1331	127	22	.	.	PUNCT
dti-1331	128	1	therefore	therefore	ADV
dti-1331	128	2	,	,	PUNCT
dti-1331	128	3	an	an	DET
dti-1331	128	4	italian	italian	ADJ
dti-1331	128	5	group	group	NOUN
dti-1331	128	6	(	(	PUNCT
dti-1331	128	7	giustizieri	giustizieri	PROPN
dti-1331	128	8	et	et	PROPN
dti-1331	128	9	al	al	PROPN
dti-1331	128	10	.	.	PROPN
dti-1331	128	11	2007	2007	NUM
dti-1331	128	12	)	)	PUNCT
dti-1331	128	13	focused	focus	VERB
dti-1331	128	14	our	our	PRON
dti-1331	128	15	attention	attention	NOUN
dti-1331	128	16	onto	onto	ADP
dti-1331	128	17	the	the	DET
dti-1331	128	18	action	action	NOUN
dti-1331	128	19	of	of	ADP
dti-1331	128	20	this	this	DET
dti-1331	128	21	drug	drug	NOUN
dti-1331	128	22	on	on	ADP
dti-1331	128	23	the	the	DET
dti-1331	128	24	dopamine	dopamine	NOUN
dti-1331	128	25	neurons	neuron	NOUN
dti-1331	128	26	of	of	ADP
dti-1331	128	27	the	the	DET
dti-1331	128	28	substantia	substantia	NOUN
dti-1331	128	29	nigra	nigra	PROPN
dti-1331	128	30	pars	par	NOUN
dti-1331	128	31	compacta	compacta	NOUN
dti-1331	128	32	(	(	PUNCT
dti-1331	128	33	snc	snc	PROPN
dti-1331	128	34	)	)	PUNCT
dti-1331	128	35	,	,	PUNCT
dti-1331	128	36	whose	whose	DET
dti-1331	128	37	progressive	progressive	ADJ
dti-1331	128	38	degeneration	degeneration	NOUN
dti-1331	128	39	is	be	AUX
dti-1331	128	40	a	a	DET
dti-1331	128	41	hallmark	hallmark	NOUN
dti-1331	128	42	of	of	ADP
dti-1331	128	43	parkinson	parkinson	NOUN
dti-1331	128	44	’s	’s	PART
dti-1331	128	45	disease	disease	NOUN
dti-1331	128	46	.	.	PUNCT
dti-1331	129	1	indeed	indeed	ADV
dti-1331	129	2	,	,	PUNCT
dti-1331	129	3	several	several	ADJ
dti-1331	129	4	lines	line	NOUN
dti-1331	129	5	of	of	ADP
dti-1331	129	6	evidence	evidence	NOUN
dti-1331	129	7	indicate	indicate	VERB
dti-1331	129	8	an	an	DET
dti-1331	129	9	overstimulation	overstimulation	NOUN
dti-1331	129	10	of	of	ADP
dti-1331	129	11	glutamate	glutamate	ADJ
dti-1331	129	12	receptors	receptor	NOUN
dti-1331	129	13	,	,	PUNCT
dti-1331	129	14	especially	especially	ADV
dti-1331	129	15	of	of	ADP
dti-1331	129	16	the	the	DET
dti-1331	129	17	nmda	nmda	ADJ
dti-1331	129	18	subtype	subtype	NOUN
dti-1331	129	19	,	,	PUNCT
dti-1331	129	20	as	as	ADP
dti-1331	129	21	the	the	DET
dti-1331	129	22	main	main	ADJ
dti-1331	129	23	cause	cause	NOUN
dti-1331	129	24	of	of	ADP
dti-1331	129	25	the	the	DET
dti-1331	129	26	progressive	progressive	ADJ
dti-1331	129	27	loss	loss	NOUN
dti-1331	129	28	of	of	ADP
dti-1331	129	29	this	this	DET
dti-1331	129	30	neuronal	neuronal	ADJ
dti-1331	129	31	population	population	NOUN
dti-1331	129	32	(	(	PUNCT
dti-1331	129	33	gardoni	gardoni	NOUN
dti-1331	129	34	and	and	CCONJ
dti-1331	129	35	di	di	PROPN
dti-1331	129	36	luca	luca	PROPN
dti-1331	129	37	,	,	PUNCT
dti-1331	129	38	2006	2006	NUM
dti-1331	129	39	)	)	PUNCT
dti-1331	129	40	.	.	PUNCT
dti-1331	130	1	memantine	memantine	PROPN
dti-1331	130	2	has	have	AUX
dti-1331	130	3	been	be	AUX
dti-1331	130	4	showed	show	VERB
dti-1331	130	5	not	not	PART
dti-1331	130	6	only	only	ADV
dti-1331	130	7	to	to	PART
dti-1331	130	8	increase	increase	VERB
dti-1331	130	9	the	the	DET
dti-1331	130	10	fi	fi	NOUN
dti-1331	130	11	ring	ring	NOUN
dti-1331	130	12	rate	rate	NOUN
dti-1331	130	13	of	of	ADP
dti-1331	130	14	the	the	DET
dti-1331	130	15	dopamine	dopamine	NOUN
dti-1331	130	16	neurons	neuron	NOUN
dti-1331	130	17	,	,	PUNCT
dti-1331	130	18	but	but	CCONJ
dti-1331	130	19	also	also	ADV
dti-1331	130	20	changed	change	VERB
dti-1331	130	21	occasionally	occasionally	ADV
dti-1331	130	22	their	their	PRON
dti-1331	130	23	fi	fi	NOUN
dti-1331	130	24	ring	ring	NOUN
dti-1331	130	25	mode	mode	NOUN
dti-1331	130	26	,	,	PUNCT
dti-1331	130	27	from	from	ADP
dti-1331	130	28	tonic	tonic	NOUN
dti-1331	130	29	to	to	ADP
dti-1331	130	30	bursting	bursting	NOUN
dti-1331	130	31	behavior	behavior	NOUN
dti-1331	130	32	.	.	PUNCT
dti-1331	131	1	this	this	DET
dti-1331	131	2	change	change	NOUN
dti-1331	131	3	in	in	ADP
dti-1331	131	4	the	the	DET
dti-1331	131	5	fi	fi	NOUN
dti-1331	131	6	ring	ring	NOUN
dti-1331	131	7	pattern	pattern	NOUN
dti-1331	131	8	may	may	AUX
dti-1331	131	9	have	have	VERB
dti-1331	131	10	important	important	ADJ
dti-1331	131	11	functional	functional	ADJ
dti-1331	131	12	implications	implication	NOUN
dti-1331	131	13	,	,	PUNCT
dti-1331	131	14	as	as	SCONJ
dti-1331	131	15	burst	burst	ADJ
dti-1331	131	16	fi	fi	NOUN
dti-1331	131	17	ring	ring	NOUN
dti-1331	131	18	of	of	ADP
dti-1331	131	19	the	the	DET
dti-1331	131	20	dopamine	dopamine	NOUN
dti-1331	131	21	neurons	neuron	NOUN
dti-1331	131	22	has	have	AUX
dti-1331	131	23	been	be	AUX
dti-1331	131	24	associated	associate	VERB
dti-1331	131	25	to	to	ADP
dti-1331	131	26	increased	increase	VERB
dti-1331	131	27	release	release	NOUN
dti-1331	131	28	of	of	ADP
dti-1331	131	29	dopamine	dopamine	NOUN
dti-1331	131	30	in	in	ADP
dti-1331	131	31	the	the	DET
dti-1331	131	32	areas	area	NOUN
dti-1331	131	33	of	of	ADP
dti-1331	131	34	nigral	nigral	ADJ
dti-1331	131	35	projection	projection	NOUN
dti-1331	131	36	(	(	PUNCT
dti-1331	131	37	floresco	floresco	PROPN
dti-1331	131	38	et	et	PROPN
dti-1331	131	39	al	al	PROPN
dti-1331	131	40	.	.	PROPN
dti-1331	131	41	2003	2003	NUM
dti-1331	131	42	;	;	PUNCT
dti-1331	131	43	phillips	phillip	NOUN
dti-1331	131	44	et	et	PROPN
dti-1331	131	45	al	al	PROPN
dti-1331	131	46	.	.	PROPN
dti-1331	131	47	2003	2003	NUM
dti-1331	131	48	)	)	PUNCT
dti-1331	131	49	.	.	PUNCT
dti-1331	132	1	according	accord	VERB
dti-1331	132	2	to	to	ADP
dti-1331	132	3	the	the	DET
dti-1331	132	4	observations	observation	NOUN
dti-1331	132	5	of	of	ADP
dti-1331	132	6	giustizieri	giustizieri	PROPN
dti-1331	132	7	et	et	PROPN
dti-1331	132	8	al	al	PROPN
dti-1331	132	9	.	.	PROPN
dti-1331	133	1	(	(	PUNCT
dti-1331	133	2	2007	2007	NUM
dti-1331	133	3	)	)	PUNCT
dti-1331	133	4	,	,	PUNCT
dti-1331	133	5	memantine	memantine	NOUN
dti-1331	133	6	does	do	AUX
dti-1331	133	7	not	not	PART
dti-1331	133	8	affect	affect	VERB
dti-1331	133	9	the	the	DET
dti-1331	133	10	basal	basal	ADJ
dti-1331	133	11	fi	fi	NOUN
dti-1331	133	12	ring	ring	NOUN
dti-1331	133	13	activity	activity	NOUN
dti-1331	133	14	of	of	ADP
dti-1331	133	15	the	the	DET
dti-1331	133	16	dopamine	dopamine	NOUN
dti-1331	133	17	neurons	neuron	NOUN
dti-1331	133	18	in	in	ADP
dti-1331	133	19	physiological	physiological	ADJ
dti-1331	133	20	conditions	condition	NOUN
dti-1331	133	21	,	,	PUNCT
dti-1331	133	22	while	while	SCONJ
dti-1331	133	23	,	,	PUNCT
dti-1331	133	24	in	in	ADP
dti-1331	133	25	conditions	condition	NOUN
dti-1331	133	26	of	of	ADP
dti-1331	133	27	metabolic	metabolic	NOUN
dti-1331	133	28	stress	stress	NOUN
dti-1331	133	29	,	,	PUNCT
dti-1331	133	30	a	a	DET
dti-1331	133	31	signifi	signifi	NOUN
dti-1331	133	32	ca	can	AUX
dti-1331	133	33	nt	not	PART
dti-1331	133	34	effect	effect	VERB
dti-1331	133	35	of	of	ADP
dti-1331	133	36	memantine	memantine	NOUN
dti-1331	133	37	emerges	emerge	NOUN
dti-1331	133	38	,	,	PUNCT
dti-1331	133	39	resulting	result	VERB
dti-1331	133	40	in	in	ADP
dti-1331	133	41	recovery	recovery	NOUN
dti-1331	133	42	of	of	ADP
dti-1331	133	43	fi	fi	NOUN
dti-1331	133	44	ring	ring	NOUN
dti-1331	133	45	activity	activity	NOUN
dti-1331	133	46	of	of	ADP
dti-1331	133	47	previously	previously	ADV
dti-1331	133	48	silenced	silence	VERB
dti-1331	133	49	dopamine	dopamine	NOUN
dti-1331	133	50	neurons	neuron	NOUN
dti-1331	133	51	.	.	PUNCT
dti-1331	134	1	this	this	DET
dti-1331	134	2	property	property	NOUN
dti-1331	134	3	may	may	AUX
dti-1331	134	4	be	be	AUX
dti-1331	134	5	particularly	particularly	ADV
dti-1331	134	6	relevant	relevant	ADJ
dti-1331	134	7	in	in	ADP
dti-1331	134	8	terms	term	NOUN
dti-1331	134	9	of	of	ADP
dti-1331	134	10	fi	fi	NOUN
dti-1331	134	11	ring	ring	NOUN
dti-1331	134	12	dependent	dependent	ADJ
dti-1331	134	13	dopamine	dopamine	NOUN
dti-1331	134	14	release	release	NOUN
dti-1331	134	15	and	and	CCONJ
dti-1331	134	16	in	in	ADP
dti-1331	134	17	relation	relation	NOUN
dti-1331	134	18	to	to	ADP
dti-1331	134	19	prevention	prevention	NOUN
dti-1331	134	20	of	of	ADP
dti-1331	134	21	neuronal	neuronal	ADJ
dti-1331	134	22	loss	loss	NOUN
dti-1331	134	23	in	in	ADP
dti-1331	134	24	parkinson	parkinson	NOUN
dti-1331	134	25	’s	’s	PART
dti-1331	134	26	disease	disease	NOUN
dti-1331	134	27	.	.	PUNCT
dti-1331	135	1	the	the	DET
dti-1331	135	2	activity	activity	NOUN
dti-1331	135	3	of	of	ADP
dti-1331	135	4	complex	complex	ADJ
dti-1331	135	5	i	i	PRON
dti-1331	135	6	of	of	ADP
dti-1331	135	7	the	the	DET
dti-1331	135	8	mitochondrial	mitochondrial	ADJ
dti-1331	135	9	respiratory	respiratory	ADJ
dti-1331	135	10	chain	chain	NOUN
dti-1331	135	11	is	be	AUX
dti-1331	135	12	reduced	reduce	VERB
dti-1331	135	13	in	in	ADP
dti-1331	135	14	dopamine	dopamine	NOUN
dti-1331	135	15	neurons	neuron	NOUN
dti-1331	135	16	of	of	ADP
dti-1331	135	17	parkinsonian	parkinsonian	ADJ
dti-1331	135	18	patients	patient	NOUN
dti-1331	135	19	(	(	PUNCT
dti-1331	135	20	schapira	schapira	NOUN
dti-1331	135	21	,	,	PUNCT
dti-1331	135	22	2001	2001	NUM
dti-1331	135	23	)	)	PUNCT
dti-1331	135	24	,	,	PUNCT
dti-1331	135	25	and	and	CCONJ
dti-1331	135	26	drugs	drug	NOUN
dti-1331	135	27	acting	act	VERB
dti-1331	135	28	as	as	ADP
dti-1331	135	29	inhibitors	inhibitor	NOUN
dti-1331	135	30	of	of	ADP
dti-1331	135	31	complex	complex	ADJ
dti-1331	135	32	i	i	PRON
dti-1331	135	33	,	,	PUNCT
dti-1331	135	34	like	like	ADP
dti-1331	135	35	rotenone	rotenone	NOUN
dti-1331	135	36	or	or	CCONJ
dti-1331	135	37	1	1	NUM
dti-1331	135	38	-	-	PUNCT
dti-1331	135	39	methyl-4	methyl-4	NUM
dti-1331	135	40	-	-	PUNCT
dti-1331	135	41	phenyl-1,2,3,6tetrahydropyridine	phenyl-1,2,3,6tetrahydropyridine	NOUN
dti-1331	135	42	induce	induce	VERB
dti-1331	135	43	dopamine	dopamine	NOUN
dti-1331	135	44	neurons	neuron	NOUN
dti-1331	135	45	degeneration	degeneration	NOUN
dti-1331	135	46	(	(	PUNCT
dti-1331	135	47	przedborski	przedborski	NOUN
dti-1331	135	48	and	and	CCONJ
dti-1331	135	49	vila	vila	PROPN
dti-1331	135	50	,	,	PUNCT
dti-1331	135	51	2003	2003	NUM
dti-1331	135	52	)	)	PUNCT
dti-1331	135	53	.	.	PUNCT
dti-1331	136	1	a	a	DET
dti-1331	136	2	recent	recent	ADJ
dti-1331	136	3	report	report	NOUN
dti-1331	136	4	by	by	ADP
dti-1331	136	5	liss	liss	PROPN
dti-1331	136	6	and	and	CCONJ
dti-1331	136	7	colleagues	colleague	NOUN
dti-1331	136	8	(	(	PUNCT
dti-1331	136	9	2005	2005	NUM
dti-1331	136	10	)	)	PUNCT
dti-1331	136	11	proposed	propose	VERB
dti-1331	136	12	that	that	SCONJ
dti-1331	136	13	the	the	DET
dti-1331	136	14	selective	selective	ADJ
dti-1331	136	15	vulnerability	vulnerability	NOUN
dti-1331	136	16	of	of	ADP
dti-1331	136	17	the	the	DET
dti-1331	136	18	snc	snc	PROPN
dti-1331	136	19	dopamine	dopamine	NOUN
dti-1331	136	20	neurons	neuron	NOUN
dti-1331	136	21	in	in	ADP
dti-1331	136	22	parkinson	parkinson	NOUN
dti-1331	136	23	’s	’s	PART
dti-1331	136	24	disease	disease	NOUN
dti-1331	136	25	is	be	AUX
dti-1331	136	26	casually	casually	ADV
dti-1331	136	27	correlated	correlate	VERB
dti-1331	136	28	with	with	ADP
dti-1331	136	29	the	the	DET
dti-1331	136	30	opening	opening	NOUN
dti-1331	136	31	of	of	ADP
dti-1331	136	32	katp	katp	NOUN
dti-1331	136	33	conductances	conductance	NOUN
dti-1331	136	34	in	in	ADP
dti-1331	136	35	these	these	DET
dti-1331	136	36	neurons	neuron	NOUN
dti-1331	136	37	;	;	PUNCT
dti-1331	136	38	thus	thus	ADV
dti-1331	136	39	,	,	PUNCT
dti-1331	136	40	the	the	DET
dti-1331	136	41	presence	presence	NOUN
dti-1331	136	42	of	of	ADP
dti-1331	136	43	functional	functional	ADJ
dti-1331	136	44	katp	katp	NOUN
dti-1331	136	45	channels	channel	NOUN
dti-1331	136	46	promotes	promote	VERB
dti-1331	136	47	the	the	DET
dti-1331	136	48	selective	selective	ADJ
dti-1331	136	49	loss	loss	NOUN
dti-1331	136	50	of	of	ADP
dti-1331	136	51	snc	snc	PROPN
dti-1331	136	52	dopamine	dopamine	NOUN
dti-1331	136	53	neurons	neuron	NOUN
dti-1331	136	54	in	in	ADP
dti-1331	136	55	both	both	CCONJ
dti-1331	136	56	a	a	DET
dti-1331	136	57	genetic	genetic	ADJ
dti-1331	136	58	model	model	NOUN
dti-1331	136	59	of	of	ADP
dti-1331	136	60	parkinson	parkinson	NOUN
dti-1331	136	61	’s	’s	PART
dti-1331	136	62	disease	disease	NOUN
dti-1331	136	63	and	and	CCONJ
dti-1331	136	64	in	in	ADP
dti-1331	136	65	response	response	NOUN
dti-1331	136	66	to	to	ADP
dti-1331	136	67	mitochondrial	mitochondrial	ADJ
dti-1331	136	68	complex	complex	NOUN
dti-1331	136	69	i	i	PRON
dti-1331	136	70	inhibition	inhibition	VERB
dti-1331	136	71	.	.	PUNCT
dti-1331	137	1	at	at	ADP
dti-1331	137	2	present	present	ADJ
dti-1331	137	3	,	,	PUNCT
dti-1331	137	4	the	the	DET
dti-1331	137	5	mechanism	mechanism	NOUN
dti-1331	137	6	through	through	ADP
dti-1331	137	7	which	which	PRON
dti-1331	137	8	katp	katp	NOUN
dti-1331	137	9	channel	channel	NOUN
dti-1331	137	10	opening	opening	NOUN
dti-1331	137	11	contributes	contribute	VERB
dti-1331	137	12	to	to	ADP
dti-1331	137	13	dopamine	dopamine	NOUN
dti-1331	137	14	neurons	neuron	NOUN
dti-1331	137	15	degeneration	degeneration	NOUN
dti-1331	137	16	is	be	AUX
dti-1331	137	17	still	still	ADV
dti-1331	137	18	unclear	unclear	ADJ
dti-1331	137	19	.	.	PUNCT
dti-1331	138	1	there	there	PRON
dti-1331	138	2	is	be	VERB
dti-1331	138	3	evidence	evidence	NOUN
dti-1331	138	4	that	that	SCONJ
dti-1331	138	5	increasing	increase	VERB
dti-1331	138	6	neuronal	neuronal	ADJ
dti-1331	138	7	excitability	excitability	NOUN
dti-1331	138	8	protects	protect	VERB
dti-1331	138	9	dopamine	dopamine	NOUN
dti-1331	138	10	neurons	neuron	NOUN
dti-1331	138	11	from	from	ADP
dti-1331	138	12	degeneration	degeneration	NOUN
dti-1331	138	13	(	(	PUNCT
dti-1331	138	14	salthunlassalle	salthunlassalle	NOUN
dti-1331	138	15	et	et	PROPN
dti-1331	138	16	al	al	PROPN
dti-1331	138	17	.	.	PROPN
dti-1331	138	18	2004	2004	NUM
dti-1331	138	19	)	)	PUNCT
dti-1331	138	20	,	,	PUNCT
dti-1331	138	21	for	for	ADP
dti-1331	138	22	this	this	DET
dti-1331	138	23	reason	reason	NOUN
dti-1331	138	24	liss	liss	VERB
dti-1331	138	25	and	and	CCONJ
dti-1331	138	26	colleagues	colleague	NOUN
dti-1331	138	27	(	(	PUNCT
dti-1331	138	28	2005	2005	NUM
dti-1331	138	29	)	)	PUNCT
dti-1331	138	30	proposed	propose	VERB
dti-1331	138	31	that	that	SCONJ
dti-1331	138	32	drugs	drug	NOUN
dti-1331	138	33	acting	act	VERB
dti-1331	138	34	at	at	ADP
dti-1331	138	35	katp	katp	NOUN
dti-1331	138	36	channels	channel	NOUN
dti-1331	138	37	of	of	ADP
dti-1331	138	38	snc	snc	PROPN
dti-1331	138	39	dopamine	dopamine	NOUN
dti-1331	138	40	neurons	neuron	NOUN
dti-1331	138	41	,	,	PUNCT
dti-1331	138	42	should	should	AUX
dti-1331	138	43	cause	cause	VERB
dti-1331	138	44	82	82	NUM
dti-1331	138	45	moretti	moretti	PROPN
dti-1331	138	46	et	et	PROPN
dti-1331	138	47	al	al	PROPN
dti-1331	138	48	drug	drug	PROPN
dti-1331	138	49	target	target	NOUN
dti-1331	138	50	insights	insight	NOUN
dti-1331	138	51	2008:3	2008:3	NUM
dti-1331	138	52	a	a	DET
dti-1331	138	53	recovery	recovery	NOUN
dti-1331	138	54	from	from	ADP
dti-1331	138	55	their	their	PRON
dti-1331	138	56	functional	functional	ADJ
dti-1331	138	57	silencing	silencing	NOUN
dti-1331	138	58	,	,	PUNCT
dti-1331	138	59	thus	thus	ADV
dti-1331	138	60	providing	provide	VERB
dti-1331	138	61	a	a	DET
dti-1331	138	62	clinical	clinical	ADJ
dti-1331	138	63	benefi	benefi	NOUN
dti-1331	138	64	t	t	PROPN
dti-1331	138	65	in	in	ADP
dti-1331	138	66	the	the	DET
dti-1331	138	67	treatment	treatment	NOUN
dti-1331	138	68	of	of	ADP
dti-1331	138	69	parkinson	parkinson	NOUN
dti-1331	138	70	’s	’s	PART
dti-1331	138	71	disease	disease	NOUN
dti-1331	138	72	.	.	PUNCT
dti-1331	139	1	indeed	indeed	ADV
dti-1331	139	2	,	,	PUNCT
dti-1331	139	3	memantine	memantine	NOUN
dti-1331	139	4	has	have	AUX
dti-1331	139	5	been	be	AUX
dti-1331	139	6	shown	show	VERB
dti-1331	139	7	to	to	PART
dti-1331	139	8	prevent	prevent	VERB
dti-1331	139	9	cell	cell	NOUN
dti-1331	139	10	death	death	NOUN
dti-1331	139	11	associated	associate	VERB
dti-1331	139	12	to	to	ADP
dti-1331	139	13	parkinson	parkinson	NOUN
dti-1331	139	14	’s	’s	PART
dti-1331	139	15	disease	disease	NOUN
dti-1331	139	16	(	(	PUNCT
dti-1331	139	17	merello	merello	NOUN
dti-1331	139	18	et	et	PROPN
dti-1331	139	19	al	al	PROPN
dti-1331	139	20	.	.	PROPN
dti-1331	139	21	1999	1999	NUM
dti-1331	139	22	;	;	PUNCT
dti-1331	139	23	kucheryanu	kucheryanu	NOUN
dti-1331	139	24	and	and	CCONJ
dti-1331	139	25	kryzhanovskii	kryzhanovskii	ADJ
dti-1331	139	26	,	,	PUNCT
dti-1331	139	27	2000	2000	NUM
dti-1331	139	28	)	)	PUNCT
dti-1331	139	29	,	,	PUNCT
dti-1331	139	30	although	although	SCONJ
dti-1331	139	31	prevention	prevention	NOUN
dti-1331	139	32	of	of	ADP
dti-1331	139	33	excitotoxic	excitotoxic	ADJ
dti-1331	139	34	neuronal	neuronal	ADJ
dti-1331	139	35	damage	damage	NOUN
dti-1331	139	36	through	through	ADP
dti-1331	139	37	an	an	DET
dti-1331	139	38	uncompetitive	uncompetitive	ADJ
dti-1331	139	39	inhibition	inhibition	NOUN
dti-1331	139	40	of	of	ADP
dti-1331	139	41	nmda	nmda	ADJ
dti-1331	139	42	receptors	receptor	NOUN
dti-1331	139	43	has	have	AUX
dti-1331	139	44	been	be	AUX
dti-1331	139	45	proposed	propose	VERB
dti-1331	139	46	as	as	ADP
dti-1331	139	47	its	its	PRON
dti-1331	139	48	underlying	underlying	ADJ
dti-1331	139	49	mechanism	mechanism	NOUN
dti-1331	139	50	of	of	ADP
dti-1331	139	51	action	action	NOUN
dti-1331	139	52	.	.	PUNCT
dti-1331	140	1	giustizieri	giustizieri	PROPN
dti-1331	140	2	et	et	PROPN
dti-1331	140	3	al	al	PROPN
dti-1331	140	4	.	.	PROPN
dti-1331	140	5	results	result	NOUN
dti-1331	140	6	(	(	PUNCT
dti-1331	140	7	2007	2007	NUM
dti-1331	140	8	)	)	PUNCT
dti-1331	140	9	results	result	NOUN
dti-1331	140	10	show	show	VERB
dti-1331	140	11	that	that	SCONJ
dti-1331	140	12	memantine	memantine	NOUN
dti-1331	140	13	does	do	AUX
dti-1331	140	14	inhibit	inhibit	VERB
dti-1331	140	15	nmda	nmda	ADJ
dti-1331	140	16	responses	response	NOUN
dti-1331	140	17	in	in	ADP
dti-1331	140	18	the	the	DET
dti-1331	140	19	snc	snc	PROPN
dti-1331	140	20	,	,	PUNCT
dti-1331	140	21	however	however	ADV
dti-1331	140	22	,	,	PUNCT
dti-1331	140	23	memantine	memantine	NOUN
dti-1331	140	24	may	may	AUX
dti-1331	140	25	also	also	ADV
dti-1331	140	26	result	result	VERB
dti-1331	140	27	benefi	benefi	PROPN
dti-1331	140	28	cial	cial	PROPN
dti-1331	140	29	in	in	ADP
dti-1331	140	30	parkinson	parkinson	NOUN
dti-1331	140	31	’s	’s	PART
dti-1331	140	32	disease	disease	NOUN
dti-1331	140	33	patients	patient	NOUN
dti-1331	140	34	because	because	SCONJ
dti-1331	140	35	it	it	PRON
dti-1331	140	36	reduces	reduce	VERB
dti-1331	140	37	dopamine	dopamine	NOUN
dti-1331	140	38	neurons	neuron	NOUN
dti-1331	140	39	silencing	silence	VERB
dti-1331	140	40	through	through	ADP
dti-1331	140	41	closure	closure	NOUN
dti-1331	140	42	of	of	ADP
dti-1331	140	43	katp	katp	NOUN
dti-1331	140	44	conductances	conductance	NOUN
dti-1331	140	45	.	.	PUNCT
dti-1331	141	1	quite	quite	ADV
dti-1331	141	2	balancing	balance	VERB
dti-1331	141	3	the	the	DET
dti-1331	141	4	preclinical	preclinical	ADJ
dti-1331	141	5	studies	study	NOUN
dti-1331	141	6	,	,	PUNCT
dti-1331	141	7	there	there	PRON
dti-1331	141	8	are	be	VERB
dti-1331	141	9	not	not	PART
dti-1331	141	10	so	so	ADV
dti-1331	141	11	consistent	consistent	ADJ
dti-1331	141	12	data	datum	NOUN
dti-1331	141	13	in	in	ADP
dti-1331	141	14	parkinson	parkinson	NOUN
dti-1331	141	15	patients	patient	NOUN
dti-1331	141	16	in	in	ADP
dti-1331	141	17	a	a	DET
dti-1331	141	18	clinical	clinical	ADJ
dti-1331	141	19	perspective	perspective	NOUN
dti-1331	141	20	.	.	PUNCT
dti-1331	142	1	an	an	DET
dti-1331	142	2	open	open	ADJ
dti-1331	142	3	-	-	PUNCT
dti-1331	142	4	fashion	fashion	NOUN
dti-1331	142	5	study	study	NOUN
dti-1331	142	6	,	,	PUNCT
dti-1331	142	7	involving	involve	VERB
dti-1331	142	8	14	14	NUM
dti-1331	142	9	parkinsonian	parkinsonian	ADJ
dti-1331	142	10	patients	patient	NOUN
dti-1331	142	11	with	with	ADP
dti-1331	142	12	motor	motor	NOUN
dti-1331	142	13	fl	fl	PROPN
dti-1331	142	14	uctuations	uctuation	NOUN
dti-1331	142	15	taking	take	VERB
dti-1331	142	16	l	l	NOUN
dti-1331	142	17	-	-	NOUN
dti-1331	142	18	dopa	dopa	NOUN
dti-1331	142	19	,	,	PUNCT
dti-1331	142	20	has	have	AUX
dti-1331	142	21	been	be	AUX
dti-1331	142	22	conducted	conduct	VERB
dti-1331	142	23	(	(	PUNCT
dti-1331	142	24	rabey	rabey	NOUN
dti-1331	142	25	et	et	PROPN
dti-1331	142	26	al	al	PROPN
dti-1331	142	27	.	.	PROPN
dti-1331	142	28	1992	1992	NUM
dti-1331	142	29	)	)	PUNCT
dti-1331	142	30	;	;	PUNCT
dti-1331	142	31	these	these	DET
dti-1331	142	32	patients	patient	NOUN
dti-1331	142	33	were	be	AUX
dti-1331	142	34	given	give	VERB
dti-1331	142	35	a	a	DET
dti-1331	142	36	supplement	supplement	NOUN
dti-1331	142	37	of	of	ADP
dti-1331	142	38	memantine	memantine	ADJ
dti-1331	142	39	30	30	NUM
dti-1331	142	40	mg	mg	NUM
dti-1331	142	41	/	/	SYM
dti-1331	142	42	day	day	NOUN
dti-1331	142	43	.	.	PUNCT
dti-1331	143	1	after	after	ADP
dti-1331	143	2	one	one	NUM
dti-1331	143	3	month	month	NOUN
dti-1331	143	4	,	,	PUNCT
dti-1331	143	5	10	10	NUM
dti-1331	143	6	patients	patient	NOUN
dti-1331	143	7	completed	complete	VERB
dti-1331	143	8	the	the	DET
dti-1331	143	9	treatment	treatment	NOUN
dti-1331	143	10	(	(	PUNCT
dti-1331	143	11	4	4	NUM
dti-1331	143	12	discontinued	discontinue	VERB
dti-1331	143	13	it	it	PRON
dti-1331	143	14	due	due	ADP
dti-1331	143	15	to	to	ADP
dti-1331	143	16	abdominal	abdominal	ADJ
dti-1331	143	17	pain	pain	NOUN
dti-1331	143	18	,	,	PUNCT
dti-1331	143	19	psychomotor	psychomotor	NOUN
dti-1331	143	20	agitation	agitation	NOUN
dti-1331	143	21	,	,	PUNCT
dti-1331	143	22	confusion	confusion	NOUN
dti-1331	143	23	and	and	CCONJ
dti-1331	143	24	dizziness	dizziness	NOUN
dti-1331	143	25	)	)	PUNCT
dti-1331	143	26	.	.	PUNCT
dti-1331	144	1	in	in	ADP
dti-1331	144	2	5	5	NUM
dti-1331	144	3	patients	patient	NOUN
dti-1331	144	4	,	,	PUNCT
dti-1331	144	5	the	the	DET
dti-1331	144	6	main	main	ADJ
dti-1331	144	7	parkinsonian	parkinsonian	ADJ
dti-1331	144	8	features	feature	NOUN
dti-1331	144	9	improved	improve	VERB
dti-1331	144	10	signifi	signifi	NOUN
dti-1331	144	11	cantly	cantly	ADV
dti-1331	144	12	(	(	PUNCT
dti-1331	144	13	1	1	NUM
dti-1331	144	14	point	point	NOUN
dti-1331	144	15	or	or	CCONJ
dti-1331	144	16	more	more	ADJ
dti-1331	144	17	on	on	ADP
dti-1331	144	18	the	the	DET
dti-1331	144	19	webster	webster	PROPN
dti-1331	144	20	scale	scale	NOUN
dti-1331	144	21	)	)	PUNCT
dti-1331	144	22	.	.	PUNCT
dti-1331	145	1	in	in	ADP
dti-1331	145	2	6	6	NUM
dti-1331	145	3	patients	patient	NOUN
dti-1331	145	4	,	,	PUNCT
dti-1331	145	5	“	"	PUNCT
dti-1331	145	6	off	off	ADV
dti-1331	145	7	”	"	PUNCT
dti-1331	145	8	episodes	episode	NOUN
dti-1331	145	9	improved	improve	VERB
dti-1331	145	10	(	(	PUNCT
dti-1331	145	11	from	from	ADP
dti-1331	145	12	daily	daily	ADJ
dti-1331	145	13	mean	mean	NOUN
dti-1331	145	14	of	of	ADP
dti-1331	145	15	273	273	NUM
dti-1331	145	16	minutes	minute	NOUN
dti-1331	145	17	,	,	PUNCT
dti-1331	145	18	to	to	ADP
dti-1331	145	19	172	172	NUM
dti-1331	145	20	minutes	minute	NOUN
dti-1331	145	21	)	)	PUNCT
dti-1331	145	22	.	.	PUNCT
dti-1331	146	1	in	in	ADP
dti-1331	146	2	summary	summary	NOUN
dti-1331	146	3	,	,	PUNCT
dti-1331	146	4	the	the	DET
dti-1331	146	5	authors	author	NOUN
dti-1331	146	6	postulated	postulate	VERB
dti-1331	146	7	that	that	DET
dti-1331	146	8	memantine	memantine	NOUN
dti-1331	146	9	addition	addition	NOUN
dti-1331	146	10	to	to	ADP
dti-1331	146	11	parkinsonian	parkinsonian	ADJ
dti-1331	146	12	features	feature	NOUN
dti-1331	146	13	,	,	PUNCT
dti-1331	146	14	could	could	AUX
dti-1331	146	15	form	form	VERB
dti-1331	146	16	a	a	DET
dti-1331	146	17	basis	basis	NOUN
dti-1331	146	18	for	for	ADP
dti-1331	146	19	novel	novel	ADJ
dti-1331	146	20	therapeutic	therapeutic	ADJ
dti-1331	146	21	strategies	strategy	NOUN
dti-1331	146	22	directed	direct	VERB
dti-1331	146	23	to	to	PART
dti-1331	146	24	neutralize	neutralize	VERB
dti-1331	146	25	the	the	DET
dti-1331	146	26	effects	effect	NOUN
dti-1331	146	27	of	of	ADP
dti-1331	146	28	glutamate	glutamate	NOUN
dti-1331	146	29	at	at	ADP
dti-1331	146	30	striatal	striatal	ADJ
dti-1331	146	31	and	and	CCONJ
dti-1331	146	32	subthalamic	subthalamic	ADJ
dti-1331	146	33	levels	level	NOUN
dti-1331	146	34	.	.	PUNCT
dti-1331	147	1	another	another	DET
dti-1331	147	2	work	work	NOUN
dti-1331	147	3	has	have	AUX
dti-1331	147	4	been	be	AUX
dti-1331	147	5	conducted	conduct	VERB
dti-1331	147	6	quite	quite	ADV
dti-1331	147	7	later	later	ADV
dti-1331	147	8	(	(	PUNCT
dti-1331	147	9	merello	merello	NOUN
dti-1331	147	10	et	et	PROPN
dti-1331	147	11	al	al	PROPN
dti-1331	147	12	.	.	PROPN
dti-1331	147	13	1999	1999	NUM
dti-1331	147	14	)	)	PUNCT
dti-1331	147	15	;	;	PUNCT
dti-1331	147	16	the	the	DET
dti-1331	147	17	aim	aim	NOUN
dti-1331	147	18	was	be	AUX
dti-1331	147	19	to	to	PART
dti-1331	147	20	evaluate	evaluate	VERB
dti-1331	147	21	the	the	DET
dti-1331	147	22	effect	effect	NOUN
dti-1331	147	23	of	of	ADP
dti-1331	147	24	memantine	memantine	NOUN
dti-1331	147	25	on	on	ADP
dti-1331	147	26	cardinal	cardinal	ADJ
dti-1331	147	27	symptoms	symptom	NOUN
dti-1331	147	28	of	of	ADP
dti-1331	147	29	parkinson	parkinson	NOUN
dti-1331	147	30	’s	’s	PART
dti-1331	147	31	disease	disease	NOUN
dti-1331	147	32	and	and	CCONJ
dti-1331	147	33	on	on	ADP
dti-1331	147	34	the	the	DET
dti-1331	147	35	latency	latency	NOUN
dti-1331	147	36	,	,	PUNCT
dti-1331	147	37	duration	duration	NOUN
dti-1331	147	38	,	,	PUNCT
dti-1331	147	39	and	and	CCONJ
dti-1331	147	40	magnitude	magnitude	NOUN
dti-1331	147	41	of	of	ADP
dti-1331	147	42	the	the	DET
dti-1331	147	43	response	response	NOUN
dti-1331	147	44	to	to	ADP
dti-1331	147	45	a	a	DET
dti-1331	147	46	single	single	ADJ
dti-1331	147	47	dose	dose	NOUN
dti-1331	147	48	of	of	ADP
dti-1331	147	49	l	l	NOUN
dti-1331	147	50	-	-	NOUN
dti-1331	147	51	dopa	dopa	NOUN
dti-1331	147	52	and	and	CCONJ
dti-1331	147	53	on	on	ADP
dti-1331	147	54	drug	drug	NOUN
dti-1331	147	55	-	-	PUNCT
dti-1331	147	56	induced	induce	VERB
dti-1331	147	57	dyskinesias	dyskinesia	NOUN
dti-1331	147	58	.	.	PUNCT
dti-1331	148	1	twelve	twelve	NUM
dti-1331	148	2	hoehn	hoehn	NOUN
dti-1331	148	3	-	-	PUNCT
dti-1331	148	4	yahr	yahr	VERB
dti-1331	148	5	iii	iii	PROPN
dti-1331	148	6	-	-	PUNCT
dti-1331	148	7	iv	iv	NUM
dti-1331	148	8	patients	patient	NOUN
dti-1331	148	9	with	with	ADP
dti-1331	148	10	idiopathic	idiopathic	ADJ
dti-1331	148	11	parkinson	parkinson	NOUN
dti-1331	148	12	’s	’s	PART
dti-1331	148	13	disease	disease	NOUN
dti-1331	148	14	with	with	ADP
dti-1331	148	15	motor	motor	NOUN
dti-1331	148	16	fl	fl	PROPN
dti-1331	148	17	uctuations	uctuation	NOUN
dti-1331	148	18	and	and	CCONJ
dti-1331	148	19	drug	drug	NOUN
dti-1331	148	20	-	-	PUNCT
dti-1331	148	21	induced	induce	VERB
dti-1331	148	22	dyskinesias	dyskinesia	NOUN
dti-1331	148	23	were	be	AUX
dti-1331	148	24	randomized	randomize	VERB
dti-1331	148	25	to	to	ADP
dti-1331	148	26	the	the	DET
dti-1331	148	27	nmda	nmda	ADJ
dti-1331	148	28	antagonist	antagonist	NOUN
dti-1331	148	29	memantine	memantine	NOUN
dti-1331	148	30	or	or	CCONJ
dti-1331	148	31	placebo	placebo	NOUN
dti-1331	148	32	in	in	ADP
dti-1331	148	33	a	a	DET
dti-1331	148	34	cross	cross	ADJ
dti-1331	148	35	-	-	ADJ
dti-1331	148	36	over	over	ADP
dti-1331	148	37	design	design	NOUN
dti-1331	148	38	.	.	PUNCT
dti-1331	149	1	a	a	DET
dti-1331	149	2	single	single	ADJ
dti-1331	149	3	-	-	PUNCT
dti-1331	149	4	dose	dose	NOUN
dti-1331	149	5	l	l	NOUN
dti-1331	149	6	-	-	PUNCT
dti-1331	149	7	dopa	dopa	NOUN
dti-1331	149	8	challenge	challenge	NOUN
dti-1331	149	9	was	be	AUX
dti-1331	149	10	performed	perform	VERB
dti-1331	149	11	after	after	ADP
dti-1331	149	12	each	each	DET
dti-1331	149	13	medication	medication	NOUN
dti-1331	149	14	arm	arm	NOUN
dti-1331	149	15	.	.	PUNCT
dti-1331	150	1	a	a	DET
dti-1331	150	2	signifi	signifi	NOUN
dti-1331	150	3	ca	can	AUX
dti-1331	150	4	nt	not	PART
dti-1331	150	5	drug	drug	VERB
dti-1331	150	6	effect	effect	NOUN
dti-1331	150	7	on	on	ADP
dti-1331	150	8	the	the	DET
dti-1331	150	9	unifi	unifi	PROPN
dti-1331	150	10	ed	ed	PROPN
dti-1331	150	11	parkinson	parkinson	PROPN
dti-1331	150	12	’s	’s	PART
dti-1331	150	13	disease	disease	NOUN
dti-1331	150	14	rating	rating	NOUN
dti-1331	150	15	scale	scale	NOUN
dti-1331	150	16	motor	motor	NOUN
dti-1331	150	17	score	score	NOUN
dti-1331	150	18	was	be	AUX
dti-1331	150	19	observed	observe	VERB
dti-1331	150	20	in	in	ADP
dti-1331	150	21	“	"	PUNCT
dti-1331	150	22	off	off	ADP
dti-1331	150	23	”	"	PUNCT
dti-1331	150	24	and	and	CCONJ
dti-1331	150	25	“	"	PUNCT
dti-1331	150	26	on	on	ADP
dti-1331	150	27	”	"	PUNCT
dti-1331	150	28	states	state	NOUN
dti-1331	150	29	(	(	PUNCT
dti-1331	150	30	f(1,11	f(1,11	NOUN
dti-1331	150	31	)	)	PUNCT
dti-1331	150	32	=	=	NOUN
dti-1331	150	33	13.5	13.5	NUM
dti-1331	150	34	;	;	PUNCT
dti-1331	150	35	p	p	PROPN
dti-1331	150	36	�	�	PROPN
dti-1331	150	37	0.003	0.003	NUM
dti-1331	150	38	)	)	PUNCT
dti-1331	150	39	.	.	PUNCT
dti-1331	151	1	no	no	DET
dti-1331	151	2	signifi	signifi	NOUN
dti-1331	151	3	ca	can	AUX
dti-1331	151	4	nt	not	PART
dti-1331	151	5	effect	effect	VERB
dti-1331	151	6	on	on	ADP
dti-1331	151	7	drug	drug	NOUN
dti-1331	151	8	-	-	PUNCT
dti-1331	151	9	induced	induce	VERB
dti-1331	151	10	dyskinesias	dyskinesia	NOUN
dti-1331	151	11	was	be	AUX
dti-1331	151	12	seen	see	VERB
dti-1331	151	13	.	.	PUNCT
dti-1331	152	1	the	the	DET
dti-1331	152	2	results	result	NOUN
dti-1331	152	3	suggest	suggest	VERB
dti-1331	152	4	that	that	SCONJ
dti-1331	152	5	memantine	memantine	NOUN
dti-1331	152	6	may	may	AUX
dti-1331	152	7	improve	improve	VERB
dti-1331	152	8	parkinsonian	parkinsonian	ADJ
dti-1331	152	9	symptoms	symptom	NOUN
dti-1331	152	10	independently	independently	ADV
dti-1331	152	11	of	of	ADP
dti-1331	152	12	dopaminergic	dopaminergic	ADJ
dti-1331	152	13	drugs	drug	NOUN
dti-1331	152	14	and	and	CCONJ
dti-1331	152	15	,	,	PUNCT
dti-1331	152	16	in	in	ADP
dti-1331	152	17	contrast	contrast	NOUN
dti-1331	152	18	to	to	ADP
dti-1331	152	19	recent	recent	ADJ
dti-1331	152	20	fi	fi	NOUN
dti-1331	152	21	ndings	nding	NOUN
dti-1331	152	22	with	with	ADP
dti-1331	152	23	amantadine	amantadine	NOUN
dti-1331	152	24	,	,	PUNCT
dti-1331	152	25	it	it	PRON
dti-1331	152	26	has	have	VERB
dti-1331	152	27	no	no	DET
dti-1331	152	28	effect	effect	NOUN
dti-1331	152	29	on	on	ADP
dti-1331	152	30	druginduced	druginduced	ADJ
dti-1331	152	31	dyskinesias	dyskinesia	NOUN
dti-1331	152	32	.	.	PUNCT
dti-1331	153	1	very	very	ADV
dti-1331	153	2	recently	recently	ADV
dti-1331	153	3	,	,	PUNCT
dti-1331	153	4	a	a	DET
dti-1331	153	5	new	new	ADJ
dti-1331	153	6	study	study	NOUN
dti-1331	153	7	has	have	AUX
dti-1331	153	8	been	be	AUX
dti-1331	153	9	conducted	conduct	VERB
dti-1331	153	10	to	to	PART
dti-1331	153	11	determine	determine	VERB
dti-1331	153	12	the	the	DET
dti-1331	153	13	effect	effect	NOUN
dti-1331	153	14	of	of	ADP
dti-1331	153	15	memantine	memantine	NOUN
dti-1331	153	16	on	on	ADP
dti-1331	153	17	parkinson	parkinson	NOUN
dti-1331	153	18	disease	disease	NOUN
dti-1331	153	19	(	(	PUNCT
dti-1331	153	20	seeman	seeman	PROPN
dti-1331	153	21	et	et	PROPN
dti-1331	153	22	al	al	PROPN
dti-1331	153	23	.	.	PROPN
dti-1331	153	24	2007	2007	NUM
dti-1331	153	25	)	)	PUNCT
dti-1331	153	26	,	,	PUNCT
dti-1331	153	27	considering	consider	VERB
dti-1331	153	28	that	that	SCONJ
dti-1331	153	29	memantine	memantine	NOUN
dti-1331	153	30	is	be	AUX
dti-1331	153	31	reported	report	VERB
dti-1331	153	32	to	to	PART
dti-1331	153	33	improve	improve	VERB
dti-1331	153	34	symptoms	symptom	NOUN
dti-1331	153	35	in	in	ADP
dti-1331	153	36	moderate	moderate	ADJ
dti-1331	153	37	cases	case	NOUN
dti-1331	153	38	of	of	ADP
dti-1331	153	39	alzheimer	alzheimer	PROPN
dti-1331	153	40	’s	’s	PART
dti-1331	153	41	disease	disease	NOUN
dti-1331	153	42	and	and	CCONJ
dti-1331	153	43	parkinson	parkinson	NOUN
dti-1331	153	44	’s	’s	PART
dti-1331	153	45	disease	disease	NOUN
dti-1331	153	46	,	,	PUNCT
dti-1331	153	47	but	but	CCONJ
dti-1331	153	48	is	be	AUX
dti-1331	153	49	also	also	ADV
dti-1331	153	50	known	know	VERB
dti-1331	153	51	to	to	PART
dti-1331	153	52	trigger	trigger	VERB
dti-1331	153	53	psychosis	psychosis	NOUN
dti-1331	153	54	in	in	ADP
dti-1331	153	55	some	some	DET
dti-1331	153	56	parkinson	parkinson	NOUN
dti-1331	153	57	patients	patient	NOUN
dti-1331	153	58	.	.	PUNCT
dti-1331	154	1	because	because	SCONJ
dti-1331	154	2	these	these	DET
dti-1331	154	3	clinical	clinical	ADJ
dti-1331	154	4	features	feature	NOUN
dti-1331	154	5	suggested	suggest	VERB
dti-1331	154	6	a	a	DET
dti-1331	154	7	possible	possible	ADJ
dti-1331	154	8	dopamine	dopamine	NOUN
dti-1331	154	9	component	component	NOUN
dti-1331	154	10	of	of	ADP
dti-1331	154	11	memantine	memantine	ADJ
dti-1331	154	12	action	action	NOUN
dti-1331	154	13	,	,	PUNCT
dti-1331	154	14	we	we	PRON
dti-1331	154	15	measured	measure	VERB
dti-1331	154	16	the	the	DET
dti-1331	154	17	potency	potency	NOUN
dti-1331	154	18	of	of	ADP
dti-1331	154	19	memantine	memantine	NOUN
dti-1331	154	20	on	on	ADP
dti-1331	154	21	the	the	DET
dti-1331	154	22	functional	functional	ADJ
dti-1331	154	23	high	high	ADJ
dti-1331	154	24	-	-	PUNCT
dti-1331	154	25	affi	affi	NOUN
dti-1331	154	26	nity	nity	NOUN
dti-1331	154	27	state	state	NOUN
dti-1331	154	28	of	of	ADP
dti-1331	154	29	dopamine	dopamine	NOUN
dti-1331	154	30	d2	d2	NOUN
dti-1331	154	31	receptors	receptor	NOUN
dti-1331	154	32	,	,	PUNCT
dti-1331	154	33	or	or	CCONJ
dti-1331	154	34	d2(high	d2(high	NOUN
dti-1331	154	35	)	)	PUNCT
dti-1331	154	36	.	.	PUNCT
dti-1331	155	1	using	use	VERB
dti-1331	155	2	[	[	X
dti-1331	155	3	(	(	PUNCT
dti-1331	155	4	3)h]domperidone	3)h]domperidone	NOUN
dti-1331	155	5	to	to	PART
dti-1331	155	6	label	label	NOUN
dti-1331	155	7	d2	d2	NOUN
dti-1331	155	8	receptors	receptor	NOUN
dti-1331	155	9	,	,	PUNCT
dti-1331	155	10	the	the	DET
dti-1331	155	11	memantine	memantine	NOUN
dti-1331	155	12	dissociation	dissociation	NOUN
dti-1331	155	13	constant	constant	ADJ
dti-1331	155	14	at	at	ADP
dti-1331	155	15	d2(high	d2(high	NOUN
dti-1331	155	16	)	)	PUNCT
dti-1331	155	17	was	be	AUX
dti-1331	155	18	917	917	NUM
dti-1331	156	1	+	+	NOUN
dti-1331	156	2	/−	/−	PROPN
dti-1331	156	3	23	23	NUM
dti-1331	156	4	nm	nm	NOUN
dti-1331	156	5	for	for	ADP
dti-1331	156	6	rat	rat	NOUN
dti-1331	156	7	striatal	striatal	ADJ
dti-1331	156	8	d2	d2	NOUN
dti-1331	156	9	receptors	receptor	NOUN
dti-1331	156	10	and	and	CCONJ
dti-1331	156	11	137	137	NUM
dti-1331	157	1	+	+	NOUN
dti-1331	157	2	/−	/−	PROPN
dti-1331	157	3	19	19	NUM
dti-1331	157	4	nm	nm	NOUN
dti-1331	157	5	for	for	ADP
dti-1331	157	6	human	human	ADJ
dti-1331	157	7	cloned	clone	VERB
dti-1331	157	8	d2long	d2long	NOUN
dti-1331	157	9	receptors	receptor	NOUN
dti-1331	157	10	.	.	PUNCT
dti-1331	158	1	the	the	DET
dti-1331	158	2	memantine	memantine	NOUN
dti-1331	158	3	dissociation	dissociation	NOUN
dti-1331	158	4	constant	constant	ADJ
dti-1331	158	5	for	for	ADP
dti-1331	158	6	striatal	striatal	ADJ
dti-1331	158	7	n	n	CCONJ
dti-1331	158	8	-	-	PUNCT
dti-1331	158	9	methyl	methyl	NOUN
dti-1331	158	10	-	-	PUNCT
dti-1331	158	11	d	d	NOUN
dti-1331	158	12	-	-	NOUN
dti-1331	158	13	aspartate	aspartate	ADJ
dti-1331	158	14	(	(	PUNCT
dti-1331	158	15	nmda	nmda	ADJ
dti-1331	158	16	)	)	PUNCT
dti-1331	158	17	receptors	receptor	NOUN
dti-1331	158	18	labeled	label	VERB
dti-1331	158	19	by	by	ADP
dti-1331	158	20	[	[	X
dti-1331	158	21	(	(	PUNCT
dti-1331	158	22	3)h	3)h	NUM
dti-1331	158	23	]	]	PUNCT
dti-1331	158	24	mk	mk	PROPN
dti-1331	158	25	801	801	NUM
dti-1331	158	26	was	be	AUX
dti-1331	158	27	2200	2200	NUM
dti-1331	159	1	+	+	ADJ
dti-1331	159	2	/−	/−	PROPN
dti-1331	159	3	400	400	NUM
dti-1331	159	4	nm	nm	NOUN
dti-1331	159	5	.	.	PUNCT
dti-1331	159	6	memantine	memantine	PROPN
dti-1331	159	7	stimulated	stimulate	VERB
dti-1331	159	8	the	the	DET
dti-1331	159	9	incorporation	incorporation	NOUN
dti-1331	159	10	of	of	ADP
dti-1331	159	11	[	[	X
dti-1331	159	12	(	(	PUNCT
dti-1331	159	13	35)s]gtpgamma	35)s]gtpgamma	NUM
dti-1331	159	14	-	-	PUNCT
dti-1331	159	15	s	s	NOUN
dti-1331	159	16	into	into	ADP
dti-1331	159	17	d2	d2	NOUN
dti-1331	159	18	-	-	PUNCT
dti-1331	159	19	expressing	express	VERB
dti-1331	159	20	chinese	chinese	ADJ
dti-1331	159	21	hamster	hamster	NOUN
dti-1331	159	22	ovary	ovary	ADJ
dti-1331	159	23	cells	cell	NOUN
dti-1331	159	24	with	with	ADP
dti-1331	159	25	a	a	DET
dti-1331	159	26	dissociation	dissociation	NOUN
dti-1331	159	27	constant	constant	ADJ
dti-1331	159	28	of	of	ADP
dti-1331	159	29	1200	1200	NUM
dti-1331	160	1	+	+	NOUN
dti-1331	160	2	/−	/−	PROPN
dti-1331	160	3	400	400	NUM
dti-1331	160	4	nm	nm	NOUN
dti-1331	160	5	.	.	PUNCT
dti-1331	161	1	memantine	memantine	NOUN
dti-1331	161	2	,	,	PUNCT
dti-1331	161	3	between	between	ADP
dti-1331	161	4	200	200	NUM
dti-1331	161	5	and	and	CCONJ
dti-1331	161	6	2000	2000	NUM
dti-1331	161	7	nm	nm	NOUN
dti-1331	161	8	,	,	PUNCT
dti-1331	161	9	directly	directly	ADV
dti-1331	161	10	acted	act	VERB
dti-1331	161	11	on	on	ADP
dti-1331	161	12	d2(high	d2(high	NOUN
dti-1331	161	13	)	)	PUNCT
dti-1331	161	14	to	to	PART
dti-1331	161	15	inhibit	inhibit	VERB
dti-1331	161	16	the	the	DET
dti-1331	161	17	release	release	NOUN
dti-1331	161	18	of	of	ADP
dti-1331	161	19	prolactin	prolactin	NOUN
dti-1331	161	20	from	from	ADP
dti-1331	161	21	isolated	isolated	ADJ
dti-1331	161	22	anterior	anterior	ADJ
dti-1331	161	23	pituitary	pituitary	ADJ
dti-1331	161	24	cells	cell	NOUN
dti-1331	161	25	in	in	ADP
dti-1331	161	26	culture	culture	NOUN
dti-1331	161	27	.	.	PUNCT
dti-1331	162	1	because	because	SCONJ
dti-1331	162	2	the	the	DET
dti-1331	162	3	memantine	memantine	NOUN
dti-1331	162	4	potencies	potency	NOUN
dti-1331	162	5	at	at	ADP
dti-1331	162	6	nmda	nmda	ADJ
dti-1331	162	7	receptors	receptor	NOUN
dti-1331	162	8	and	and	CCONJ
dti-1331	162	9	dopamine	dopamine	NOUN
dti-1331	162	10	d2(high	d2(high	ADJ
dti-1331	162	11	)	)	PUNCT
dti-1331	162	12	receptors	receptor	NOUN
dti-1331	162	13	are	be	AUX
dti-1331	162	14	of	of	ADP
dti-1331	162	15	a	a	DET
dti-1331	162	16	similar	similar	ADJ
dti-1331	162	17	order	order	NOUN
dti-1331	162	18	of	of	ADP
dti-1331	162	19	magnitude	magnitude	NOUN
dti-1331	162	20	,	,	PUNCT
dti-1331	162	21	it	it	PRON
dti-1331	162	22	is	be	AUX
dti-1331	162	23	likely	likely	ADJ
dti-1331	162	24	that	that	SCONJ
dti-1331	162	25	the	the	DET
dti-1331	162	26	clinical	clinical	ADJ
dti-1331	162	27	features	feature	NOUN
dti-1331	162	28	of	of	ADP
dti-1331	162	29	memantine	memantine	NOUN
dti-1331	162	30	can	can	AUX
dti-1331	162	31	be	be	AUX
dti-1331	162	32	attributed	attribute	VERB
dti-1331	162	33	to	to	ADP
dti-1331	162	34	its	its	PRON
dti-1331	162	35	action	action	NOUN
dti-1331	162	36	at	at	ADP
dti-1331	162	37	both	both	DET
dti-1331	162	38	types	type	NOUN
dti-1331	162	39	of	of	ADP
dti-1331	162	40	receptors	receptor	NOUN
dti-1331	162	41	.	.	PUNCT
dti-1331	163	1	conclusions	conclusion	NOUN
dti-1331	163	2	memantine	memantine	NOUN
dti-1331	163	3	protects	protect	VERB
dti-1331	163	4	cultured	cultured	ADJ
dti-1331	163	5	neurons	neuron	NOUN
dti-1331	163	6	from	from	ADP
dti-1331	163	7	excitotoxin	excitotoxin	PROPN
dti-1331	163	8	-	-	PUNCT
dti-1331	163	9	induced	induce	VERB
dti-1331	163	10	cell	cell	NOUN
dti-1331	163	11	-	-	PUNCT
dti-1331	163	12	death	death	NOUN
dti-1331	163	13	.	.	PUNCT
dti-1331	164	1	memantine	memantine	NOUN
dti-1331	164	2	exerts	exert	VERB
dti-1331	164	3	neuroprotective	neuroprotective	ADJ
dti-1331	164	4	effects	effect	NOUN
dti-1331	164	5	in	in	ADP
dti-1331	164	6	several	several	ADJ
dti-1331	164	7	models	model	NOUN
dti-1331	164	8	of	of	ADP
dti-1331	164	9	brain	brain	NOUN
dti-1331	164	10	injury	injury	NOUN
dti-1331	164	11	.	.	PUNCT
dti-1331	165	1	the	the	DET
dti-1331	165	2	drug	drug	NOUN
dti-1331	165	3	attenuated	attenuate	VERB
dti-1331	165	4	loss	loss	NOUN
dti-1331	165	5	of	of	ADP
dti-1331	165	6	cholinergic	cholinergic	ADJ
dti-1331	165	7	neurons	neuron	NOUN
dti-1331	165	8	in	in	ADP
dti-1331	165	9	the	the	DET
dti-1331	165	10	cns	cns	NOUN
dti-1331	165	11	induced	induce	VERB
dti-1331	165	12	by	by	ADP
dti-1331	165	13	injection	injection	NOUN
dti-1331	165	14	of	of	ADP
dti-1331	165	15	nmda	nmda	NOUN
dti-1331	165	16	into	into	ADP
dti-1331	165	17	the	the	DET
dti-1331	165	18	basal	basal	ADJ
dti-1331	165	19	forebrain	forebrain	NOUN
dti-1331	165	20	of	of	ADP
dti-1331	165	21	rats	rat	NOUN
dti-1331	165	22	.	.	PUNCT
dti-1331	166	1	it	it	PRON
dti-1331	166	2	has	have	AUX
dti-1331	166	3	been	be	AUX
dti-1331	166	4	shown	show	VERB
dti-1331	166	5	that	that	SCONJ
dti-1331	166	6	memantine	memantine	ADJ
dti-1331	166	7	induced	induce	VERB
dti-1331	166	8	production	production	NOUN
dti-1331	166	9	of	of	ADP
dti-1331	166	10	brain	brain	NOUN
dti-1331	166	11	-	-	PUNCT
dti-1331	166	12	derived	derive	VERB
dti-1331	166	13	neurotrophic	neurotrophic	ADJ
dti-1331	166	14	factor	factor	NOUN
dti-1331	166	15	(	(	PUNCT
dti-1331	166	16	bdnf	bdnf	PROPN
dti-1331	166	17	)	)	PUNCT
dti-1331	166	18	,	,	PUNCT
dti-1331	166	19	a	a	DET
dti-1331	166	20	substance	substance	NOUN
dti-1331	166	21	shown	show	VERB
dti-1331	166	22	to	to	PART
dti-1331	166	23	promote	promote	VERB
dti-1331	166	24	survival	survival	NOUN
dti-1331	166	25	and	and	CCONJ
dti-1331	166	26	differentiation	differentiation	NOUN
dti-1331	166	27	of	of	ADP
dti-1331	166	28	cns	cns	PROPN
dti-1331	166	29	neuron	neuron	PROPN
dti-1331	166	30	.	.	PUNCT
dti-1331	167	1	due	due	ADP
dti-1331	167	2	to	to	ADP
dti-1331	167	3	the	the	DET
dti-1331	167	4	preclinical	preclinical	ADJ
dti-1331	167	5	effects	effect	NOUN
dti-1331	167	6	of	of	ADP
dti-1331	167	7	memantine	memantine	NOUN
dti-1331	167	8	owing	owe	VERB
dti-1331	167	9	to	to	ADP
dti-1331	167	10	its	its	PRON
dti-1331	167	11	anti	anti	ADJ
dti-1331	167	12	-	-	ADJ
dti-1331	167	13	ischemic	ischemic	ADJ
dti-1331	167	14	and	and	CCONJ
dti-1331	167	15	anti	anti	ADJ
dti-1331	167	16	-	-	ADJ
dti-1331	167	17	excitotoxic	excitotoxic	ADJ
dti-1331	167	18	properties	property	NOUN
dti-1331	167	19	,	,	PUNCT
dti-1331	167	20	recent	recent	ADJ
dti-1331	167	21	clinical	clinical	ADJ
dti-1331	167	22	effi	effi	PROPN
dti-1331	167	23	cacy	cacy	NOUN
dti-1331	167	24	has	have	AUX
dti-1331	167	25	been	be	AUX
dti-1331	167	26	demonstrated	demonstrate	VERB
dti-1331	167	27	in	in	ADP
dti-1331	167	28	patients	patient	NOUN
dti-1331	167	29	with	with	ADP
dti-1331	167	30	advanced	advanced	ADJ
dti-1331	167	31	dementia	dementia	NOUN
dti-1331	167	32	of	of	ADP
dti-1331	167	33	vascular	vascular	ADJ
dti-1331	167	34	origins	origin	NOUN
dti-1331	167	35	.	.	PUNCT
dti-1331	168	1	therefore	therefore	ADV
dti-1331	168	2	,	,	PUNCT
dti-1331	168	3	it	it	PRON
dti-1331	168	4	has	have	AUX
dti-1331	168	5	been	be	AUX
dti-1331	168	6	employed	employ	VERB
dti-1331	168	7	in	in	ADP
dti-1331	168	8	different	different	ADJ
dti-1331	168	9	trials	trial	NOUN
dti-1331	168	10	,	,	PUNCT
dti-1331	168	11	in	in	ADP
dti-1331	168	12	vascular	vascular	ADJ
dti-1331	168	13	dementia	dementia	NOUN
dti-1331	168	14	,	,	PUNCT
dti-1331	168	15	showing	show	VERB
dti-1331	168	16	a	a	DET
dti-1331	168	17	potential	potential	ADJ
dti-1331	168	18	benefi	benefi	NOUN
dti-1331	168	19	t	t	PROPN
dti-1331	168	20	and	and	CCONJ
dti-1331	168	21	no	no	DET
dti-1331	168	22	unbearable	unbearable	ADJ
dti-1331	168	23	side	side	NOUN
dti-1331	168	24	effects	effect	NOUN
dti-1331	168	25	.	.	PUNCT
dti-1331	169	1	memantine	memantine	PROPN
dti-1331	169	2	has	have	VERB
dti-1331	169	3	a	a	DET
dti-1331	169	4	small	small	ADJ
dti-1331	169	5	benefi	benefi	NOUN
dti-1331	169	6	cial	cial	NOUN
dti-1331	169	7	,	,	PUNCT
dti-1331	169	8	clinically	clinically	ADV
dti-1331	169	9	detectable	detectable	ADJ
dti-1331	169	10	effect	effect	NOUN
dti-1331	169	11	on	on	ADP
dti-1331	169	12	cognitive	cognitive	ADJ
dti-1331	169	13	function	function	NOUN
dti-1331	169	14	and	and	CCONJ
dti-1331	169	15	83	83	NUM
dti-1331	169	16	memantine	memantine	NOUN
dti-1331	169	17	:	:	PUNCT
dti-1331	169	18	reality	reality	NOUN
dti-1331	169	19	and	and	CCONJ
dti-1331	169	20	potentiality	potentiality	NOUN
dti-1331	169	21	drug	drug	NOUN
dti-1331	169	22	target	target	NOUN
dti-1331	169	23	insights	insight	VERB
dti-1331	169	24	2008:3	2008:3	NUM
dti-1331	169	25	functional	functional	ADJ
dti-1331	169	26	decline	decline	NOUN
dti-1331	169	27	measured	measure	VERB
dti-1331	169	28	at	at	ADP
dti-1331	169	29	6	6	NUM
dti-1331	169	30	months	month	NOUN
dti-1331	169	31	in	in	ADP
dti-1331	169	32	patients	patient	NOUN
dti-1331	169	33	with	with	ADP
dti-1331	169	34	moderate	moderate	ADJ
dti-1331	169	35	to	to	ADP
dti-1331	169	36	severe	severe	ADJ
dti-1331	169	37	alzheimer	alzheimer	PROPN
dti-1331	169	38	’s	’s	PART
dti-1331	169	39	disease	disease	NOUN
dti-1331	169	40	(	(	PUNCT
dti-1331	169	41	ad	ad	NOUN
dti-1331	169	42	)	)	PUNCT
dti-1331	169	43	.	.	PUNCT
dti-1331	170	1	in	in	ADP
dti-1331	170	2	patients	patient	NOUN
dti-1331	170	3	with	with	ADP
dti-1331	170	4	mild	mild	ADJ
dti-1331	170	5	to	to	ADP
dti-1331	170	6	moderate	moderate	ADJ
dti-1331	170	7	dementia	dementia	NOUN
dti-1331	170	8	,	,	PUNCT
dti-1331	170	9	the	the	DET
dti-1331	170	10	small	small	ADJ
dti-1331	170	11	benefi	benefi	PROPN
dti-1331	170	12	cial	cial	ADJ
dti-1331	170	13	effect	effect	NOUN
dti-1331	170	14	on	on	ADP
dti-1331	170	15	cognition	cognition	NOUN
dti-1331	170	16	was	be	AUX
dti-1331	170	17	not	not	PART
dti-1331	170	18	clinically	clinically	ADV
dti-1331	170	19	detectable	detectable	ADJ
dti-1331	170	20	in	in	ADP
dti-1331	170	21	those	those	PRON
dti-1331	170	22	with	with	ADP
dti-1331	170	23	vascular	vascular	ADJ
dti-1331	170	24	dementia	dementia	NOUN
dti-1331	170	25	and	and	CCONJ
dti-1331	170	26	barely	barely	ADV
dti-1331	170	27	detectable	detectable	ADJ
dti-1331	170	28	in	in	ADP
dti-1331	170	29	those	those	PRON
dti-1331	170	30	with	with	ADP
dti-1331	170	31	ad	ad	NOUN
dti-1331	170	32	.	.	PUNCT
dti-1331	171	1	it	it	PRON
dti-1331	171	2	is	be	AUX
dti-1331	171	3	well	well	ADV
dti-1331	171	4	tolerated	tolerate	VERB
dti-1331	171	5	(	(	PUNCT
dti-1331	171	6	mcshane	mcshane	PROPN
dti-1331	171	7	et	et	PROPN
dti-1331	171	8	al	al	PROPN
dti-1331	171	9	.	.	PROPN
dti-1331	171	10	2007	2007	NUM
dti-1331	171	11	)	)	PUNCT
dti-1331	171	12	.	.	PUNCT
dti-1331	172	1	main	main	ADJ
dti-1331	172	2	results	result	NOUN
dti-1331	172	3	can	can	AUX
dti-1331	172	4	be	be	AUX
dti-1331	172	5	summarized	summarize	VERB
dti-1331	172	6	as	as	SCONJ
dti-1331	172	7	follows	follow	VERB
dti-1331	172	8	:	:	PUNCT
dti-1331	172	9	1	1	X
dti-1331	172	10	.	.	NUM
dti-1331	172	11	moderate	moderate	ADJ
dti-1331	172	12	to	to	ADP
dti-1331	172	13	severe	severe	ADJ
dti-1331	172	14	ad	ad	NOUN
dti-1331	172	15	.	.	PUNCT
dti-1331	173	1	two	two	NUM
dti-1331	173	2	out	out	ADP
dti-1331	173	3	of	of	ADP
dti-1331	173	4	three	three	NUM
dti-1331	173	5	six	six	NUM
dti-1331	173	6	month	month	NOUN
dti-1331	173	7	studies	study	NOUN
dti-1331	173	8	show	show	VERB
dti-1331	173	9	a	a	DET
dti-1331	173	10	small	small	ADJ
dti-1331	173	11	benefi	benefi	NOUN
dti-1331	173	12	cial	cial	ADJ
dti-1331	173	13	effect	effect	NOUN
dti-1331	173	14	of	of	ADP
dti-1331	173	15	memantine	memantine	NOUN
dti-1331	173	16	.	.	PUNCT
dti-1331	174	1	pooled	pool	VERB
dti-1331	174	2	data	datum	NOUN
dti-1331	174	3	indicate	indicate	VERB
dti-1331	174	4	a	a	DET
dti-1331	174	5	benefi	benefi	PROPN
dti-1331	174	6	cial	cial	ADJ
dti-1331	174	7	effect	effect	NOUN
dti-1331	174	8	at	at	ADP
dti-1331	174	9	six	six	NUM
dti-1331	174	10	months	month	NOUN
dti-1331	174	11	on	on	ADP
dti-1331	174	12	cognition	cognition	NOUN
dti-1331	174	13	(	(	PUNCT
dti-1331	174	14	2.97	2.97	NUM
dti-1331	174	15	points	point	NOUN
dti-1331	174	16	on	on	ADP
dti-1331	174	17	the	the	DET
dti-1331	174	18	100	100	NUM
dti-1331	174	19	point	point	NOUN
dti-1331	174	20	sib	sib	NOUN
dti-1331	174	21	,	,	PUNCT
dti-1331	174	22	95	95	NUM
dti-1331	174	23	%	%	NOUN
dti-1331	174	24	ci	ci	NOUN
dti-1331	174	25	1.68	1.68	NUM
dti-1331	174	26	to	to	ADP
dti-1331	174	27	4.26	4.26	NUM
dti-1331	174	28	,	,	PUNCT
dti-1331	174	29	p	p	PROPN
dti-1331	174	30	�	�	PROPN
dti-1331	174	31	0.00001	0.00001	NUM
dti-1331	174	32	)	)	PUNCT
dti-1331	174	33	,	,	PUNCT
dti-1331	174	34	activities	activity	NOUN
dti-1331	174	35	of	of	ADP
dti-1331	174	36	daily	daily	ADJ
dti-1331	174	37	living	living	NOUN
dti-1331	174	38	(	(	PUNCT
dti-1331	174	39	1.27	1.27	NUM
dti-1331	174	40	points	point	NOUN
dti-1331	174	41	on	on	ADP
dti-1331	174	42	the	the	DET
dti-1331	174	43	54	54	NUM
dti-1331	174	44	point	point	NOUN
dti-1331	174	45	adcs	adcs	ADV
dti-1331	174	46	-	-	PUNCT
dti-1331	174	47	adlsev	adlsev	ADJ
dti-1331	174	48	,	,	PUNCT
dti-1331	174	49	95	95	NUM
dti-1331	174	50	%	%	NOUN
dti-1331	174	51	ci	ci	NOUN
dti-1331	174	52	0.44	0.44	NUM
dti-1331	174	53	to	to	ADP
dti-1331	174	54	2.09	2.09	NUM
dti-1331	174	55	,	,	PUNCT
dti-1331	174	56	p	p	X
dti-1331	174	57	=	=	NOUN
dti-1331	174	58	0.003	0.003	NUM
dti-1331	174	59	)	)	PUNCT
dti-1331	174	60	and	and	CCONJ
dti-1331	174	61	behaviour	behaviour	NOUN
dti-1331	174	62	(	(	PUNCT
dti-1331	174	63	2.76	2.76	NUM
dti-1331	174	64	points	point	NOUN
dti-1331	174	65	on	on	ADP
dti-1331	174	66	the	the	DET
dti-1331	174	67	144	144	NUM
dti-1331	174	68	point	point	NOUN
dti-1331	174	69	npi	npi	PROPN
dti-1331	174	70	,	,	PUNCT
dti-1331	174	71	95	95	NUM
dti-1331	174	72	%	%	NOUN
dti-1331	174	73	ci	ci	NOUN
dti-1331	174	74	0.88	0.88	NUM
dti-1331	174	75	to	to	ADP
dti-1331	174	76	4.63	4.63	NUM
dti-1331	174	77	,	,	PUNCT
dti-1331	174	78	p	p	X
dti-1331	174	79	=	=	NOUN
dti-1331	174	80	0.004	0.004	NUM
dti-1331	174	81	)	)	PUNCT
dti-1331	174	82	,	,	PUNCT
dti-1331	174	83	supported	support	VERB
dti-1331	174	84	by	by	ADP
dti-1331	174	85	clinical	clinical	ADJ
dti-1331	174	86	impression	impression	NOUN
dti-1331	174	87	of	of	ADP
dti-1331	174	88	change	change	NOUN
dti-1331	174	89	(	(	PUNCT
dti-1331	174	90	0.28	0.28	NUM
dti-1331	174	91	points	point	NOUN
dti-1331	174	92	on	on	ADP
dti-1331	174	93	the	the	DET
dti-1331	174	94	7	7	NUM
dti-1331	174	95	point	point	NOUN
dti-1331	174	96	cibic+	cibic+	ADJ
dti-1331	174	97	,	,	PUNCT
dti-1331	174	98	95	95	NUM
dti-1331	174	99	%	%	NOUN
dti-1331	174	100	ci	ci	NOUN
dti-1331	174	101	0.15	0.15	NUM
dti-1331	174	102	to	to	ADP
dti-1331	174	103	0.41	0.41	NUM
dti-1331	174	104	,	,	PUNCT
dti-1331	174	105	p	p	PROPN
dti-1331	174	106	�	�	PROPN
dti-1331	174	107	0.0001	0.0001	NUM
dti-1331	174	108	)	)	PUNCT
dti-1331	174	109	.	.	PUNCT
dti-1331	175	1	2	2	X
dti-1331	175	2	.	.	X
dti-1331	175	3	mild	mild	ADJ
dti-1331	175	4	to	to	ADP
dti-1331	175	5	moderate	moderate	ADJ
dti-1331	175	6	ad	ad	NOUN
dti-1331	175	7	.	.	PUNCT
dti-1331	176	1	pooled	pool	VERB
dti-1331	176	2	data	datum	NOUN
dti-1331	176	3	from	from	ADP
dti-1331	176	4	three	three	NUM
dti-1331	176	5	unpublished	unpublished	ADJ
dti-1331	176	6	studies	study	NOUN
dti-1331	176	7	indicate	indicate	VERB
dti-1331	176	8	a	a	DET
dti-1331	176	9	marginal	marginal	ADJ
dti-1331	176	10	benefical	benefical	ADJ
dti-1331	176	11	effect	effect	NOUN
dti-1331	176	12	at	at	ADP
dti-1331	176	13	six	six	NUM
dti-1331	176	14	months	month	NOUN
dti-1331	176	15	on	on	ADP
dti-1331	176	16	itt	itt	ADJ
dti-1331	176	17	cognition	cognition	NOUN
dti-1331	176	18	(	(	PUNCT
dti-1331	176	19	0.99	0.99	NUM
dti-1331	176	20	points	point	NOUN
dti-1331	176	21	on	on	ADP
dti-1331	176	22	the	the	DET
dti-1331	176	23	70	70	NUM
dti-1331	176	24	point	point	NOUN
dti-1331	176	25	adas	adas	PROPN
dti-1331	176	26	-	-	PUNCT
dti-1331	176	27	cog	cog	PROPN
dti-1331	176	28	,	,	PUNCT
dti-1331	176	29	95	95	NUM
dti-1331	176	30	%	%	NOUN
dti-1331	176	31	ci	ci	NOUN
dti-1331	176	32	0.21	0.21	NUM
dti-1331	176	33	to	to	ADP
dti-1331	176	34	1.78	1.78	NUM
dti-1331	176	35	,	,	PUNCT
dti-1331	176	36	p	p	X
dti-1331	176	37	=	=	NOUN
dti-1331	176	38	0.01	0.01	NUM
dti-1331	176	39	)	)	PUNCT
dti-1331	176	40	which	which	PRON
dti-1331	176	41	was	be	AUX
dti-1331	176	42	barely	barely	ADV
dti-1331	176	43	detectable	detectable	ADJ
dti-1331	176	44	clinically	clinically	ADV
dti-1331	176	45	(	(	PUNCT
dti-1331	176	46	0.13	0.13	NUM
dti-1331	176	47	cibic+	cibic+	NOUN
dti-1331	176	48	points	point	NOUN
dti-1331	176	49	,	,	PUNCT
dti-1331	176	50	95	95	NUM
dti-1331	176	51	%	%	NOUN
dti-1331	176	52	ci	ci	NOUN
dti-1331	176	53	0.01	0.01	NUM
dti-1331	176	54	to	to	ADP
dti-1331	176	55	0.25	0.25	NUM
dti-1331	176	56	,	,	PUNCT
dti-1331	176	57	p	p	X
dti-1331	176	58	=	=	NOUN
dti-1331	176	59	0.03	0.03	NUM
dti-1331	176	60	)	)	PUNCT
dti-1331	176	61	but	but	CCONJ
dti-1331	176	62	no	no	DET
dti-1331	176	63	effect	effect	NOUN
dti-1331	176	64	on	on	ADP
dti-1331	176	65	behaviour	behaviour	NOUN
dti-1331	176	66	,	,	PUNCT
dti-1331	176	67	activities	activity	NOUN
dti-1331	176	68	of	of	ADP
dti-1331	176	69	daily	daily	ADJ
dti-1331	176	70	living	living	NOUN
dti-1331	176	71	or	or	CCONJ
dti-1331	176	72	oc	oc	VERB
dti-1331	176	73	analysis	analysis	NOUN
dti-1331	176	74	of	of	ADP
dti-1331	176	75	cognition	cognition	NOUN
dti-1331	176	76	.	.	PUNCT
dti-1331	177	1	3	3	X
dti-1331	177	2	.	.	X
dti-1331	177	3	mild	mild	ADJ
dti-1331	177	4	to	to	ADP
dti-1331	177	5	moderate	moderate	ADJ
dti-1331	177	6	vascular	vascular	ADJ
dti-1331	177	7	dementia	dementia	NOUN
dti-1331	177	8	.	.	PUNCT
dti-1331	178	1	pooled	pool	VERB
dti-1331	178	2	data	datum	NOUN
dti-1331	178	3	from	from	ADP
dti-1331	178	4	two	two	NUM
dti-1331	178	5	six	six	NUM
dti-1331	178	6	month	month	NOUN
dti-1331	178	7	studies	study	NOUN
dti-1331	178	8	indicated	indicate	VERB
dti-1331	178	9	a	a	DET
dti-1331	178	10	small	small	ADJ
dti-1331	178	11	benefi	benefi	NOUN
dti-1331	178	12	cial	cial	ADJ
dti-1331	178	13	effect	effect	NOUN
dti-1331	178	14	of	of	ADP
dti-1331	178	15	memantine	memantine	NOUN
dti-1331	178	16	on	on	ADP
dti-1331	178	17	cognition	cognition	NOUN
dti-1331	178	18	(	(	PUNCT
dti-1331	178	19	1.85	1.85	NUM
dti-1331	178	20	adas	adas	PROPN
dti-1331	178	21	-	-	PUNCT
dti-1331	178	22	cog	cog	PROPN
dti-1331	178	23	points	point	NOUN
dti-1331	178	24	,	,	PUNCT
dti-1331	178	25	95	95	NUM
dti-1331	178	26	%	%	NOUN
dti-1331	178	27	ci	ci	NOUN
dti-1331	178	28	0.88	0.88	NUM
dti-1331	178	29	to	to	ADP
dti-1331	178	30	2.83	2.83	NUM
dti-1331	178	31	,	,	PUNCT
dti-1331	178	32	p	p	X
dti-1331	178	33	=	=	NOUN
dti-1331	178	34	0.0002	0.0002	NUM
dti-1331	178	35	)	)	PUNCT
dti-1331	178	36	,	,	PUNCT
dti-1331	178	37	and	and	CCONJ
dti-1331	178	38	behaviour	behaviour	NOUN
dti-1331	178	39	(	(	PUNCT
dti-1331	178	40	0.84	0.84	NUM
dti-1331	178	41	95	95	NUM
dti-1331	178	42	%	%	NOUN
dti-1331	178	43	ci	ci	NOUN
dti-1331	178	44	0.06	0.06	NUM
dti-1331	178	45	to	to	ADP
dti-1331	178	46	0.91	0.91	NUM
dti-1331	178	47	,	,	PUNCT
dti-1331	178	48	p	p	X
dti-1331	178	49	=	=	NOUN
dti-1331	178	50	0.03	0.03	NUM
dti-1331	178	51	)	)	PUNCT
dti-1331	178	52	but	but	CCONJ
dti-1331	178	53	this	this	PRON
dti-1331	178	54	was	be	AUX
dti-1331	178	55	not	not	PART
dti-1331	178	56	supported	support	VERB
dti-1331	178	57	by	by	ADP
dti-1331	178	58	clinical	clinical	ADJ
dti-1331	178	59	global	global	ADJ
dti-1331	178	60	measures	measure	NOUN
dti-1331	178	61	.	.	PUNCT
dti-1331	179	1	4	4	X
dti-1331	179	2	.	.	X
dti-1331	179	3	patients	patient	NOUN
dti-1331	179	4	taking	take	VERB
dti-1331	179	5	memantine	memantine	NOUN
dti-1331	179	6	were	be	AUX
dti-1331	179	7	slightly	slightly	ADV
dti-1331	179	8	less	less	ADV
dti-1331	179	9	likely	likely	ADJ
dti-1331	179	10	to	to	PART
dti-1331	179	11	develop	develop	VERB
dti-1331	179	12	agitation	agitation	NOUN
dti-1331	179	13	(	(	PUNCT
dti-1331	179	14	134/1739	134/1739	NUM
dti-1331	179	15	,	,	PUNCT
dti-1331	179	16	7.7	7.7	NUM
dti-1331	179	17	%	%	NOUN
dti-1331	179	18	versus	versus	ADP
dti-1331	179	19	175/1873	175/1873	NUM
dti-1331	179	20	,	,	PUNCT
dti-1331	179	21	9.3	9.3	NUM
dti-1331	179	22	%	%	NOUN
dti-1331	179	23	or	or	CCONJ
dti-1331	179	24	0.78	0.78	NUM
dti-1331	179	25	,	,	PUNCT
dti-1331	179	26	95	95	NUM
dti-1331	179	27	%	%	NOUN
dti-1331	179	28	ci	ci	NOUN
dti-1331	179	29	0.61	0.61	NUM
dti-1331	179	30	to	to	ADP
dti-1331	179	31	0.99	0.99	NUM
dti-1331	179	32	,	,	PUNCT
dti-1331	179	33	p	p	NOUN
dti-1331	179	34	=	=	NOUN
dti-1331	179	35	0.04	0.04	NUM
dti-1331	179	36	)	)	PUNCT
dti-1331	179	37	.	.	PUNCT
dti-1331	180	1	this	this	DET
dti-1331	180	2	effect	effect	NOUN
dti-1331	180	3	was	be	AUX
dti-1331	180	4	slightly	slightly	ADV
dti-1331	180	5	larger	large	ADJ
dti-1331	180	6	,	,	PUNCT
dti-1331	180	7	but	but	CCONJ
dti-1331	180	8	still	still	ADV
dti-1331	180	9	small	small	ADJ
dti-1331	180	10	,	,	PUNCT
dti-1331	180	11	in	in	ADP
dti-1331	180	12	moderate	moderate	ADJ
dti-1331	180	13	to	to	ADP
dti-1331	180	14	severe	severe	ADJ
dti-1331	180	15	ad	ad	NOUN
dti-1331	180	16	(	(	PUNCT
dti-1331	180	17	58/506	58/506	NUM
dti-1331	180	18	[	[	X
dti-1331	180	19	12	12	NUM
dti-1331	180	20	%	%	NOUN
dti-1331	180	21	]	]	PUNCT
dti-1331	180	22	vs	vs	ADP
dti-1331	180	23	88/499	88/499	NUM
dti-1331	181	1	[	[	SYM
dti-1331	181	2	18	18	NUM
dti-1331	181	3	%	%	NOUN
dti-1331	181	4	]	]	X
dti-1331	181	5	;	;	PUNCT
dti-1331	181	6	or	or	CCONJ
dti-1331	181	7	=	=	SYM
dti-1331	181	8	0.6	0.6	NUM
dti-1331	181	9	,	,	PUNCT
dti-1331	181	10	95	95	NUM
dti-1331	181	11	%	%	NOUN
dti-1331	181	12	ci	ci	NOUN
dti-1331	181	13	0.42	0.42	NUM
dti-1331	181	14	to	to	ADP
dti-1331	181	15	0.86	0.86	NUM
dti-1331	181	16	,	,	PUNCT
dti-1331	181	17	p	p	NOUN
dti-1331	181	18	=	=	NOUN
dti-1331	181	19	0.005	0.005	NUM
dti-1331	181	20	)	)	PUNCT
dti-1331	181	21	.	.	PUNCT
dti-1331	182	1	there	there	PRON
dti-1331	182	2	is	be	VERB
dti-1331	182	3	no	no	DET
dti-1331	182	4	evidence	evidence	NOUN
dti-1331	182	5	either	either	DET
dti-1331	182	6	way	way	NOUN
dti-1331	182	7	about	about	ADP
dti-1331	182	8	whether	whether	SCONJ
dti-1331	182	9	it	it	PRON
dti-1331	182	10	has	have	AUX
dti-1331	182	11	an	an	DET
dti-1331	182	12	effect	effect	NOUN
dti-1331	182	13	on	on	ADP
dti-1331	182	14	agitation	agitation	NOUN
dti-1331	182	15	which	which	PRON
dti-1331	182	16	is	be	AUX
dti-1331	182	17	already	already	ADV
dti-1331	182	18	present	present	ADJ
dti-1331	182	19	.	.	PUNCT
dti-1331	183	1	importantly	importantly	ADV
dti-1331	183	2	,	,	PUNCT
dti-1331	183	3	however	however	ADV
dti-1331	183	4	,	,	PUNCT
dti-1331	183	5	it	it	PRON
dti-1331	183	6	does	do	AUX
dti-1331	183	7	appear	appear	VERB
dti-1331	183	8	that	that	SCONJ
dti-1331	183	9	the	the	DET
dti-1331	183	10	dementia	dementia	NOUN
dti-1331	183	11	caused	cause	VERB
dti-1331	183	12	by	by	ADP
dti-1331	183	13	brain	brain	NOUN
dti-1331	183	14	vascular	vascular	ADJ
dti-1331	183	15	disease	disease	NOUN
dti-1331	183	16	may	may	AUX
dti-1331	183	17	share	share	VERB
dti-1331	183	18	similar	similar	ADJ
dti-1331	183	19	anatomic	anatomic	ADJ
dti-1331	183	20	substrates	substrate	NOUN
dti-1331	183	21	with	with	ADP
dti-1331	183	22	ad	ad	NOUN
dti-1331	183	23	,	,	PUNCT
dti-1331	183	24	supporting	support	VERB
dti-1331	183	25	the	the	DET
dti-1331	183	26	notion	notion	NOUN
dti-1331	183	27	of	of	ADP
dti-1331	183	28	a	a	DET
dti-1331	183	29	common	common	ADJ
dti-1331	183	30	substrate	substrate	NOUN
dti-1331	183	31	to	to	ADP
dti-1331	183	32	dementia	dementia	NOUN
dti-1331	183	33	.	.	PUNCT
dti-1331	184	1	different	different	ADJ
dti-1331	184	2	studies	study	NOUN
dti-1331	184	3	suggest	suggest	VERB
dti-1331	184	4	that	that	SCONJ
dti-1331	184	5	memantine	memantine	NOUN
dti-1331	184	6	should	should	AUX
dti-1331	184	7	be	be	AUX
dti-1331	184	8	studied	study	VERB
dti-1331	184	9	in	in	ADP
dti-1331	184	10	a	a	DET
dti-1331	184	11	wider	wide	ADJ
dti-1331	184	12	and	and	CCONJ
dti-1331	184	13	broader	broad	ADJ
dti-1331	184	14	population	population	NOUN
dti-1331	184	15	,	,	PUNCT
dti-1331	184	16	even	even	ADV
dti-1331	184	17	in	in	ADP
dti-1331	184	18	parkinson	parkinson	NOUN
dti-1331	184	19	disease	disease	NOUN
dti-1331	184	20	,	,	PUNCT
dti-1331	184	21	but	but	CCONJ
dti-1331	184	22	results	result	NOUN
dti-1331	184	23	are	be	AUX
dti-1331	184	24	quite	quite	ADV
dti-1331	184	25	experimental	experimental	ADJ
dti-1331	184	26	.	.	PUNCT
dti-1331	185	1	it	it	PRON
dti-1331	185	2	might	might	AUX
dti-1331	185	3	be	be	AUX
dti-1331	185	4	postulated	postulate	VERB
dti-1331	185	5	that	that	SCONJ
dti-1331	185	6	many	many	ADJ
dti-1331	185	7	studies	study	NOUN
dti-1331	185	8	should	should	AUX
dti-1331	185	9	be	be	AUX
dti-1331	185	10	designed	design	VERB
dti-1331	185	11	to	to	PART
dti-1331	185	12	define	define	VERB
dti-1331	185	13	the	the	DET
dti-1331	185	14	real	real	ADJ
dti-1331	185	15	clinical	clinical	ADJ
dti-1331	185	16	relevance	relevance	NOUN
dti-1331	185	17	of	of	ADP
dti-1331	185	18	the	the	DET
dti-1331	185	19	laboratory	laboratory	NOUN
dti-1331	185	20	and	and	CCONJ
dti-1331	185	21	pre	pre	ADJ
dti-1331	185	22	-	-	ADJ
dti-1331	185	23	clinical	clinical	ADJ
dti-1331	185	24	observations	observation	NOUN
dti-1331	185	25	.	.	PUNCT
dti-1331	186	1	note	note	VERB
dti-1331	186	2	the	the	DET
dti-1331	186	3	authors	author	NOUN
dti-1331	186	4	express	express	VERB
dti-1331	186	5	their	their	PRON
dti-1331	186	6	gratitude	gratitude	NOUN
dti-1331	186	7	to	to	ADP
dti-1331	186	8	ms	ms	PROPN
dti-1331	186	9	mara	mara	PROPN
dti-1331	186	10	conte	conte	PROPN
dti-1331	186	11	for	for	ADP
dti-1331	186	12	her	her	PRON
dti-1331	186	13	precious	precious	ADJ
dti-1331	186	14	help	help	NOUN
dti-1331	186	15	for	for	ADP
dti-1331	186	16	the	the	DET
dti-1331	186	17	corrections	correction	NOUN
dti-1331	186	18	of	of	ADP
dti-1331	186	19	the	the	DET
dti-1331	186	20	text	text	NOUN
dti-1331	186	21	.	.	PUNCT
dti-1331	187	1	references	reference	NOUN
dti-1331	187	2	ambrozi	ambrozi	PROPN
dti-1331	187	3	,	,	PUNCT
dti-1331	187	4	l.	l.	PROPN
dti-1331	187	5	and	and	CCONJ
dti-1331	187	6	danieczyk	danieczyk	PROPN
dti-1331	187	7	,	,	PUNCT
dti-1331	187	8	w.	w.	PROPN
dti-1331	187	9	1988	1988	NUM
dti-1331	187	10	,	,	PUNCT
dti-1331	187	11	may	may	AUX
dti-1331	187	12	.	.	PUNCT
dti-1331	188	1	treatment	treatment	NOUN
dti-1331	188	2	of	of	ADP
dti-1331	188	3	impaired	impaired	ADJ
dti-1331	188	4	cerebral	cerebral	ADJ
dti-1331	188	5	function	function	NOUN
dti-1331	188	6	in	in	ADP
dti-1331	188	7	psychogeriatric	psychogeriatric	NOUN
dti-1331	188	8	patients	patient	NOUN
dti-1331	188	9	with	with	ADP
dti-1331	188	10	memantine	memantine	NOUN
dti-1331	188	11	—	—	PUNCT
dti-1331	188	12	results	result	NOUN
dti-1331	188	13	of	of	ADP
dti-1331	188	14	a	a	DET
dti-1331	188	15	phase	phase	NOUN
dti-1331	188	16	ii	ii	NOUN
dti-1331	188	17	double	double	ADJ
dti-1331	188	18	-	-	PUNCT
dti-1331	188	19	blind	blind	ADJ
dti-1331	188	20	study	study	NOUN
dti-1331	188	21	.	.	PUNCT
dti-1331	189	1	pharmacopsychiatry	pharmacopsychiatry	NOUN
dti-1331	189	2	,	,	PUNCT
dti-1331	189	3	21(3):144–6	21(3):144–6	PRON
dti-1331	189	4	.	.	PUNCT
dti-1331	190	1	blanpied	blanpie	VERB
dti-1331	190	2	,	,	PUNCT
dti-1331	190	3	t.a	t.a	PROPN
dti-1331	190	4	.	.	PROPN
dti-1331	190	5	,	,	PUNCT
dti-1331	190	6	boeckman	boeckman	PROPN
dti-1331	190	7	,	,	PUNCT
dti-1331	190	8	f.a	f.a	PROPN
dti-1331	190	9	.	.	PROPN
dti-1331	190	10	,	,	PUNCT
dti-1331	190	11	aizenman	aizenman	NOUN
dti-1331	190	12	,	,	PUNCT
dti-1331	190	13	e.	e.	PROPN
dti-1331	190	14	et	et	PROPN
dti-1331	190	15	al	al	PROPN
dti-1331	190	16	.	.	PROPN
dti-1331	190	17	1997	1997	NUM
dti-1331	190	18	,	,	PUNCT
dti-1331	190	19	jan	jan	PROPN
dti-1331	190	20	.	.	PUNCT
dti-1331	191	1	trapping	trap	VERB
dti-1331	191	2	channel	channel	NOUN
dti-1331	191	3	block	block	NOUN
dti-1331	191	4	of	of	ADP
dti-1331	191	5	nmda	nmda	ADJ
dti-1331	191	6	-	-	PUNCT
dti-1331	191	7	activated	activate	VERB
dti-1331	191	8	responses	response	NOUN
dti-1331	191	9	by	by	ADP
dti-1331	191	10	amantadine	amantadine	NOUN
dti-1331	191	11	and	and	CCONJ
dti-1331	191	12	memantine	memantine	NOUN
dti-1331	191	13	.	.	PUNCT
dti-1331	192	1	j.	j.	PROPN
dti-1331	192	2	neurophysiol	neurophysiol	PROPN
dti-1331	192	3	.	.	PUNCT
dti-1331	193	1	,	,	PUNCT
dti-1331	193	2	77(i):309–23	77(i):309–23	PROPN
dti-1331	193	3	.	.	PUNCT
dti-1331	193	4	bleich	bleich	PROPN
dti-1331	193	5	,	,	PUNCT
dti-1331	193	6	s.	s.	PROPN
dti-1331	193	7	,	,	PUNCT
dti-1331	193	8	wiltfang	wiltfang	PROPN
dti-1331	193	9	,	,	PUNCT
dti-1331	193	10	j.	j.	PROPN
dti-1331	193	11	,	,	PUNCT
dti-1331	193	12	kornhuber	kornhuber	PROPN
dti-1331	193	13	,	,	PUNCT
dti-1331	193	14	j.	j.	PROPN
dti-1331	193	15	,	,	PUNCT
dti-1331	193	16	reisberg	reisberg	PROPN
dti-1331	193	17	,	,	PUNCT
dti-1331	193	18	b.	b.	PROPN
dti-1331	193	19	,	,	PUNCT
dti-1331	193	20	doody	doody	PROPN
dti-1331	193	21	,	,	PUNCT
dti-1331	193	22	r.	r.	PROPN
dti-1331	193	23	and	and	CCONJ
dti-1331	193	24	möbius	möbius	PROPN
dti-1331	193	25	,	,	PUNCT
dti-1331	193	26	h.j	h.j	PROPN
dti-1331	193	27	.	.	PROPN
dti-1331	193	28	2003	2003	NUM
dti-1331	193	29	.	.	PUNCT
dti-1331	194	1	memantine	memantine	NOUN
dti-1331	194	2	in	in	ADP
dti-1331	194	3	moderate	moderate	ADJ
dti-1331	194	4	-	-	PUNCT
dti-1331	194	5	to	to	ADP
dti-1331	194	6	-	-	PUNCT
dti-1331	194	7	severe	severe	ADJ
dti-1331	194	8	alzheimer	alzheimer	PROPN
dti-1331	194	9	’s	’s	PART
dti-1331	194	10	disease	disease	NOUN
dti-1331	194	11	.	.	PUNCT
dti-1331	195	1	n.	n.	PROPN
dti-1331	195	2	engl	engl	PROPN
dti-1331	195	3	.	.	PUNCT
dti-1331	196	1	j.	j.	PROPN
dti-1331	196	2	med	med	PROPN
dti-1331	196	3	.	.	PROPN
dti-1331	196	4	,	,	PUNCT
dti-1331	196	5	349:609–10	349:609–10	NUM
dti-1331	196	6	.	.	PUNCT
dti-1331	197	1	bormann	bormann	PROPN
dti-1331	197	2	,	,	PUNCT
dti-1331	197	3	j.	j.	PROPN
dti-1331	197	4	1989	1989	NUM
dti-1331	197	5	,	,	PUNCT
dti-1331	197	6	aug	aug	PROPN
dti-1331	197	7	3	3	NUM
dti-1331	197	8	.	.	NOUN
dti-1331	197	9	memantine	memantine	NOUN
dti-1331	197	10	is	be	AUX
dti-1331	197	11	a	a	DET
dti-1331	197	12	potent	potent	ADJ
dti-1331	197	13	blocker	blocker	NOUN
dti-1331	197	14	of	of	ADP
dti-1331	197	15	n.-methyldaspartate	n.-methyldaspartate	PROPN
dti-1331	197	16	(	(	PUNCT
dti-1331	197	17	nmda	nmda	ADJ
dti-1331	197	18	)	)	PUNCT
dti-1331	197	19	receptor	receptor	NOUN
dti-1331	197	20	channels	channel	NOUN
dti-1331	197	21	.	.	PUNCT
dti-1331	198	1	eur	eur	PROPN
dti-1331	198	2	.	.	PUNCT
dti-1331	199	1	j.	j.	PROPN
dti-1331	199	2	pharmacol	pharmacol	PROPN
dti-1331	199	3	.	.	PROPN
dti-1331	199	4	,	,	PUNCT
dti-1331	199	5	166(3):591–2	166(3):591–2	NUM
dti-1331	199	6	.	.	PUNCT
dti-1331	200	1	braak	braak	PROPN
dti-1331	200	2	,	,	PUNCT
dti-1331	200	3	h.	h.	PROPN
dti-1331	200	4	,	,	PUNCT
dti-1331	200	5	braak	braak	PROPN
dti-1331	200	6	,	,	PUNCT
dti-1331	200	7	e.	e.	PROPN
dti-1331	200	8	and	and	CCONJ
dti-1331	200	9	bohl	bohl	PROPN
dti-1331	200	10	,	,	PUNCT
dti-1331	200	11	j.	j.	PROPN
dti-1331	200	12	1993	1993	NUM
dti-1331	200	13	.	.	PUNCT
dti-1331	201	1	staging	staging	NOUN
dti-1331	201	2	of	of	ADP
dti-1331	201	3	alzheimer	alzheimer	PROPN
dti-1331	201	4	related	relate	VERB
dti-1331	201	5	cortical	cortical	ADJ
dti-1331	201	6	destruction	destruction	NOUN
dti-1331	201	7	.	.	PUNCT
dti-1331	202	1	eur	eur	ADJ
dti-1331	202	2	.	.	PUNCT
dti-1331	203	1	neurol	neurol	PROPN
dti-1331	203	2	.	.	PUNCT
dti-1331	203	3	,	,	PUNCT
dti-1331	203	4	33:403–8	33:403–8	NUM
dti-1331	203	5	.	.	PUNCT
dti-1331	204	1	brorson	brorson	PROPN
dti-1331	204	2	,	,	PUNCT
dti-1331	204	3	j.r	j.r	PROPN
dti-1331	204	4	.	.	PROPN
dti-1331	204	5	,	,	PUNCT
dti-1331	204	6	bindokas	bindokas	PROPN
dti-1331	204	7	,	,	PUNCT
dti-1331	204	8	y.p	y.p	PROPN
dti-1331	204	9	.	.	PROPN
dti-1331	204	10	,	,	PUNCT
dti-1331	204	11	iwama	iwama	PROPN
dti-1331	204	12	,	,	PUNCT
dti-1331	204	13	i.	i.	PROPN
dti-1331	204	14	,	,	PUNCT
dti-1331	204	15	marcuccilli	marcuccilli	PROPN
dti-1331	204	16	,	,	PUNCT
dti-1331	204	17	c.j	c.j	PROPN
dti-1331	204	18	.	.	PROPN
dti-1331	204	19	,	,	PUNCT
dti-1331	204	20	chisholm	chisholm	PROPN
dti-1331	204	21	,	,	PUNCT
dti-1331	204	22	j.c	j.c	PROPN
dti-1331	204	23	.	.	PROPN
dti-1331	204	24	and	and	CCONJ
dti-1331	204	25	miller	miller	PROPN
dti-1331	204	26	,	,	PUNCT
dti-1331	204	27	r.j	r.j	PROPN
dti-1331	204	28	.	.	PROPN
dti-1331	204	29	1995	1995	NUM
dti-1331	204	30	.	.	PUNCT
dti-1331	205	1	the	the	DET
dti-1331	205	2	ca2	ca2	PROPN
dti-1331	205	3	+	+	PROPN
dti-1331	205	4	infl	infl	PROPN
dti-1331	205	5	ux	ux	PROPN
dti-1331	205	6	induced	induce	VERB
dti-1331	205	7	by	by	ADP
dti-1331	205	8	beta	beta	NOUN
dti-1331	205	9	-	-	PUNCT
dti-1331	205	10	amyloid	amyloid	NOUN
dti-1331	205	11	peptide	peptide	NOUN
dti-1331	205	12	25–35	25–35	NUM
dti-1331	205	13	in	in	ADP
dti-1331	205	14	cultured	cultured	ADJ
dti-1331	205	15	hippocampal	hippocampal	ADJ
dti-1331	205	16	neurons	neuron	NOUN
dti-1331	205	17	results	result	NOUN
dti-1331	205	18	from	from	ADP
dti-1331	205	19	network	network	NOUN
dti-1331	205	20	excitation	excitation	NOUN
dti-1331	205	21	.	.	PUNCT
dti-1331	206	1	j.	j.	PROPN
dti-1331	206	2	neurobiol	neurobiol	PROPN
dti-1331	206	3	.	.	PUNCT
dti-1331	206	4	,	,	PUNCT
dti-1331	206	5	26:325–38	26:325–38	PROPN
dti-1331	206	6	.	.	PUNCT
dti-1331	207	1	chapira	chapira	PROPN
dti-1331	207	2	,	,	PUNCT
dti-1331	207	3	a.h	a.h	PROPN
dti-1331	207	4	.	.	PROPN
dti-1331	207	5	2001	2001	NUM
dti-1331	207	6	.	.	PUNCT
dti-1331	208	1	causes	cause	NOUN
dti-1331	208	2	of	of	ADP
dti-1331	208	3	neuronal	neuronal	ADJ
dti-1331	208	4	death	death	NOUN
dti-1331	208	5	in	in	ADP
dti-1331	208	6	parkinson	parkinson	NOUN
dti-1331	208	7	’s	’s	PART
dti-1331	208	8	disease	disease	NOUN
dti-1331	208	9	.	.	PUNCT
dti-1331	209	1	adv	adv	PROPN
dti-1331	209	2	.	.	PUNCT
dti-1331	210	1	neurol	neurol	PROPN
dti-1331	210	2	.	.	PUNCT
dti-1331	211	1	,	,	PUNCT
dti-1331	211	2	86:155–62	86:155–62	NOUN
dti-1331	211	3	.	.	PUNCT
dti-1331	212	1	chen	chen	PROPN
dti-1331	212	2	,	,	PUNCT
dti-1331	212	3	h	h	PROPN
dti-1331	212	4	-	-	PUNCT
dti-1331	212	5	s.	s.	PROPN
dti-1331	212	6	and	and	CCONJ
dti-1331	212	7	lipton	lipton	PROPN
dti-1331	212	8	,	,	PUNCT
dti-1331	212	9	s.a	s.a	PROPN
dti-1331	212	10	.	.	PROPN
dti-1331	212	11	1997	1997	NUM
dti-1331	212	12	,	,	PUNCT
dti-1331	212	13	feb	feb	PROPN
dti-1331	212	14	15	15	NUM
dti-1331	212	15	.	.	PUNCT
dti-1331	212	16	mechanism	mechanism	NOUN
dti-1331	212	17	of	of	ADP
dti-1331	212	18	memantine	memantine	ADJ
dti-1331	212	19	block	block	NOUN
dti-1331	212	20	of	of	ADP
dti-1331	212	21	nmda	nmda	ADJ
dti-1331	212	22	-	-	PUNCT
dti-1331	212	23	activated	activate	VERB
dti-1331	212	24	channels	channel	NOUN
dti-1331	212	25	in	in	ADP
dti-1331	212	26	rat	rat	NOUN
dti-1331	212	27	retinal	retinal	ADJ
dti-1331	212	28	ganglion	ganglion	NOUN
dti-1331	212	29	cells	cell	NOUN
dti-1331	212	30	:	:	PUNCT
dti-1331	212	31	uncompetitive	uncompetitive	ADJ
dti-1331	212	32	antagonism	antagonism	NOUN
dti-1331	212	33	.	.	PUNCT
dti-1331	213	1	j.	j.	PROPN
dti-1331	213	2	physiol	physiol	PROPN
dti-1331	213	3	.	.	PUNCT
dti-1331	214	1	,	,	PUNCT
dti-1331	214	2	499(pt	499(pt	NUM
dti-1331	214	3	i):27–46	i):27–46	NOUN
dti-1331	214	4	.	.	PUNCT
dti-1331	215	1	choi	choi	NOUN
dti-1331	215	2	,	,	PUNCT
dti-1331	215	3	d.w	d.w	PROPN
dti-1331	215	4	.	.	PROPN
dti-1331	215	5	1995	1995	NUM
dti-1331	215	6	.	.	PUNCT
dti-1331	216	1	calcium	calcium	NOUN
dti-1331	216	2	:	:	PUNCT
dti-1331	216	3	still	still	ADV
dti-1331	216	4	center	center	ADJ
dti-1331	216	5	-	-	PUNCT
dti-1331	216	6	stage	stage	NOUN
dti-1331	216	7	in	in	ADP
dti-1331	216	8	hypoxicischemic	hypoxicischemic	ADJ
dti-1331	216	9	neuronal	neuronal	ADJ
dti-1331	216	10	death	death	NOUN
dti-1331	216	11	.	.	PUNCT
dti-1331	217	1	trends	trend	NOUN
dti-1331	217	2	neurosci	neurosci	PROPN
dti-1331	217	3	.	.	PUNCT
dti-1331	217	4	,	,	PUNCT
dti-1331	217	5	18:58–60	18:58–60	PROPN
dti-1331	217	6	.	.	PUNCT
dti-1331	218	1	cullen	cullen	PROPN
dti-1331	218	2	,	,	PUNCT
dti-1331	218	3	w.k	w.k	PROPN
dti-1331	218	4	.	.	PROPN
dti-1331	218	5	,	,	PUNCT
dti-1331	218	6	wu	wu	PROPN
dti-1331	218	7	,	,	PUNCT
dti-1331	218	8	j.q	j.q	PROPN
dti-1331	218	9	.	.	PROPN
dti-1331	218	10	,	,	PUNCT
dti-1331	218	11	anwyl	anwyl	PROPN
dti-1331	218	12	,	,	PUNCT
dti-1331	218	13	r.	r.	PROPN
dti-1331	218	14	and	and	CCONJ
dti-1331	218	15	rowan	rowan	PROPN
dti-1331	218	16	,	,	PUNCT
dti-1331	218	17	m.j	m.j	PROPN
dti-1331	218	18	.	.	PROPN
dti-1331	218	19	1996	1996	NUM
dti-1331	218	20	.	.	PUNCT
dti-1331	219	1	beta	beta	ADJ
dti-1331	219	2	amyloid	amyloid	NOUN
dti-1331	219	3	produces	produce	VERB
dti-1331	219	4	a	a	DET
dti-1331	219	5	delayed	delay	VERB
dti-1331	219	6	nmda	nmda	ADJ
dti-1331	219	7	receptor	receptor	NOUN
dti-1331	219	8	-	-	PUNCT
dti-1331	219	9	dependent	dependent	ADJ
dti-1331	219	10	reduction	reduction	NOUN
dti-1331	219	11	in	in	ADP
dti-1331	219	12	synaptic	synaptic	ADJ
dti-1331	219	13	transmission	transmission	NOUN
dti-1331	219	14	in	in	ADP
dti-1331	219	15	rat	rat	NOUN
dti-1331	219	16	hippocampus	hippocampus	NOUN
dti-1331	219	17	.	.	PUNCT
dti-1331	220	1	neuroreport	neuroreport	NOUN
dti-1331	220	2	.	.	PUNCT
dti-1331	220	3	,	,	PUNCT
dti-1331	220	4	8:87–92	8:87–92	NUM
dti-1331	220	5	.	.	PUNCT
dti-1331	221	1	danysz	danysz	NOUN
dti-1331	221	2	,	,	PUNCT
dti-1331	221	3	w.	w.	PROPN
dti-1331	221	4	,	,	PUNCT
dti-1331	221	5	zajaczkowski	zajaczkowski	PROPN
dti-1331	221	6	,	,	PUNCT
dti-1331	221	7	w.	w.	PROPN
dti-1331	221	8	and	and	CCONJ
dti-1331	221	9	parsons	parsons	PROPN
dti-1331	221	10	,	,	PUNCT
dti-1331	221	11	c.g	c.g	PROPN
dti-1331	221	12	.	.	PROPN
dti-1331	221	13	1995	1995	NUM
dti-1331	221	14	.	.	PUNCT
dti-1331	222	1	modulation	modulation	NOUN
dti-1331	222	2	of	of	ADP
dti-1331	222	3	learning	learn	VERB
dti-1331	222	4	processes	process	NOUN
dti-1331	222	5	by	by	ADP
dti-1331	222	6	ionotropic	ionotropic	ADJ
dti-1331	222	7	glutamate	glutamate	ADJ
dti-1331	222	8	receptor	receptor	NOUN
dti-1331	222	9	ligands	ligand	NOUN
dti-1331	222	10	.	.	PUNCT
dti-1331	223	1	behav	behav	NOUN
dti-1331	223	2	.	.	PUNCT
dti-1331	224	1	pharmacal	pharmacal	ADJ
dti-1331	224	2	.	.	PUNCT
dti-1331	224	3	,	,	PUNCT
dti-1331	225	1	6:455–74	6:455–74	PROPN
dti-1331	225	2	.	.	PUNCT
dti-1331	225	3	danysz	danysz	PROPN
dti-1331	225	4	,	,	PUNCT
dti-1331	225	5	w.	w.	PROPN
dti-1331	225	6	,	,	PUNCT
dti-1331	225	7	parsons	parson	NOUN
dti-1331	225	8	,	,	PUNCT
dti-1331	225	9	c.g	c.g	PROPN
dti-1331	225	10	.	.	PROPN
dti-1331	225	11	,	,	PUNCT
dti-1331	225	12	mobius	mobius	PROPN
dti-1331	225	13	,	,	PUNCT
dti-1331	225	14	h.j	h.j	PROPN
dti-1331	225	15	.	.	PROPN
dti-1331	225	16	,	,	PUNCT
dti-1331	225	17	stoffl	stoffl	PROPN
dti-1331	225	18	er	er	INTJ
dti-1331	225	19	,	,	PUNCT
dti-1331	225	20	a.	a.	NOUN
dti-1331	225	21	and	and	CCONJ
dti-1331	225	22	quack	quack	INTJ
dti-1331	225	23	,	,	PUNCT
dti-1331	225	24	g.	g.	PROPN
dti-1331	225	25	2000	2000	NUM
dti-1331	225	26	.	.	PUNCT
dti-1331	226	1	neuroprotective	neuroprotective	ADJ
dti-1331	226	2	and	and	CCONJ
dti-1331	226	3	symptomatological	symptomatological	ADJ
dti-1331	226	4	action	action	NOUN
dti-1331	226	5	of	of	ADP
dti-1331	226	6	memantine	memantine	NOUN
dti-1331	226	7	relevant	relevant	ADJ
dti-1331	226	8	for	for	ADP
dti-1331	226	9	alzheimer	alzheimer	PROPN
dti-1331	226	10	’s	’s	PART
dti-1331	226	11	disease	disease	NOUN
dti-1331	226	12	—	—	PUNCT
dti-1331	226	13	a	a	DET
dti-1331	226	14	unifi	unifi	NOUN
dti-1331	226	15	ed	ed	PRON
dti-1331	226	16	glutamatergic	glutamatergic	ADJ
dti-1331	226	17	hypothesis	hypothesis	NOUN
dti-1331	226	18	on	on	ADP
dti-1331	226	19	the	the	DET
dti-1331	226	20	mechanism	mechanism	NOUN
dti-1331	226	21	of	of	ADP
dti-1331	226	22	action	action	NOUN
dti-1331	226	23	.	.	PUNCT
dti-1331	227	1	neurotoxicity	neurotoxicity	NOUN
dti-1331	227	2	res	re	NOUN
dti-1331	227	3	.	.	PUNCT
dti-1331	227	4	,	,	PUNCT
dti-1331	228	1	2:85–97	2:85–97	X
dti-1331	228	2	.	.	PUNCT
dti-1331	229	1	demaerschalk	demaerschalk	NOUN
dti-1331	229	2	,	,	PUNCT
dti-1331	229	3	b.m	b.m	PROPN
dti-1331	229	4	.	.	PROPN
dti-1331	229	5	and	and	CCONJ
dti-1331	229	6	wingerchuk	wingerchuk	NOUN
dti-1331	229	7	,	,	PUNCT
dti-1331	229	8	d.m	d.m	PROPN
dti-1331	229	9	.	.	PROPN
dti-1331	229	10	2007	2007	NUM
dti-1331	229	11	,	,	PUNCT
dti-1331	229	12	jan	jan	PROPN
dti-1331	229	13	.	.	PROPN
dti-1331	229	14	treatment	treatment	NOUN
dti-1331	229	15	of	of	ADP
dti-1331	229	16	vascular	vascular	ADJ
dti-1331	229	17	dementia	dementia	NOUN
dti-1331	229	18	and	and	CCONJ
dti-1331	229	19	vascular	vascular	ADJ
dti-1331	229	20	cognitive	cognitive	ADJ
dti-1331	229	21	impairment	impairment	NOUN
dti-1331	229	22	.	.	PUNCT
dti-1331	230	1	neurologist	neurologist	NOUN
dti-1331	230	2	,	,	PUNCT
dti-1331	230	3	13(1):37–41	13(1):37–41	NUM
dti-1331	230	4	.	.	PUNCT
dti-1331	231	1	dogan	dogan	PROPN
dti-1331	231	2	,	,	PUNCT
dti-1331	231	3	a.	a.	NOUN
dti-1331	231	4	,	,	PUNCT
dti-1331	231	5	eras	era	NOUN
dti-1331	231	6	,	,	PUNCT
dti-1331	231	7	m.a	m.a	PROPN
dti-1331	231	8	.	.	PROPN
dti-1331	231	9	,	,	PUNCT
dti-1331	231	10	rao	rao	PROPN
dti-1331	231	11	,	,	PUNCT
dti-1331	231	12	vlr	vlr	PROPN
dti-1331	231	13	.	.	PUNCT
dti-1331	231	14	et	et	PROPN
dti-1331	232	1	al	al	PROPN
dti-1331	232	2	.	.	PROPN
dti-1331	232	3	1999	1999	NUM
dti-1331	232	4	.	.	PUNCT
dti-1331	233	1	protective	protective	ADJ
dti-1331	233	2	effects	effect	NOUN
dti-1331	233	3	of	of	ADP
dti-1331	233	4	memantine	memantine	NOUN
dti-1331	233	5	against	against	ADP
dti-1331	233	6	ischemia	ischemia	NOUN
dti-1331	233	7	-	-	PUNCT
dti-1331	233	8	reperfusion	reperfusion	NOUN
dti-1331	233	9	injury	injury	NOUN
dti-1331	233	10	in	in	ADP
dti-1331	233	11	spontaneously	spontaneously	ADV
dti-1331	233	12	hypertensive	hypertensive	ADJ
dti-1331	233	13	rats	rat	NOUN
dti-1331	233	14	.	.	PUNCT
dti-1331	234	1	acta	acta	PROPN
dti-1331	234	2	.	.	PUNCT
dti-1331	235	1	neurochir	neurochir	NOUN
dti-1331	235	2	(	(	PUNCT
dti-1331	235	3	wien	wien	PROPN
dti-1331	235	4	)	)	PUNCT
dti-1331	235	5	.	.	PUNCT
dti-1331	235	6	,	,	PUNCT
dti-1331	235	7	141(10):1107–13	141(10):1107–13	NUM
dti-1331	235	8	.	.	X
dti-1331	235	9	erdo	erdo	NOUN
dti-1331	235	10	,	,	PUNCT
dti-1331	235	11	s.l	s.l	PROPN
dti-1331	235	12	.	.	PROPN
dti-1331	235	13	and	and	CCONJ
dti-1331	235	14	schafer	schafer	PROPN
dti-1331	235	15	,	,	PUNCT
dti-1331	235	16	m.	m.	NOUN
dti-1331	235	17	1991	1991	NUM
dti-1331	235	18	,	,	PUNCT
dti-1331	235	19	jun	jun	PROPN
dti-1331	235	20	6	6	NUM
dti-1331	235	21	.	.	X
dti-1331	235	22	memantine	memantine	NOUN
dti-1331	235	23	is	be	AUX
dti-1331	235	24	highly	highly	ADV
dti-1331	235	25	potent	potent	ADJ
dti-1331	235	26	in	in	ADP
dti-1331	235	27	protecting	protect	VERB
dti-1331	235	28	cortical	cortical	ADJ
dti-1331	235	29	cultures	culture	NOUN
dti-1331	235	30	against	against	ADP
dti-1331	235	31	excitotoxic	excitotoxic	ADJ
dti-1331	235	32	cell	cell	NOUN
dti-1331	235	33	death	death	NOUN
dti-1331	235	34	evoked	evoke	VERB
dti-1331	235	35	by	by	ADP
dti-1331	235	36	glutamate	glutamate	NOUN
dti-1331	235	37	and	and	CCONJ
dti-1331	235	38	n.-methyj.-d	n.-methyj.-d	NOUN
dti-1331	235	39	-	-	PUNCT
dti-1331	235	40	aspartate	aspartate	NOUN
dti-1331	235	41	.	.	PUNCT
dti-1331	236	1	eur	eur	PROPN
dti-1331	236	2	.	.	PUNCT
dti-1331	237	1	j.	j.	PROPN
dti-1331	237	2	pharmacol	pharmacol	PROPN
dti-1331	237	3	.	.	PROPN
dti-1331	237	4	,	,	PUNCT
dti-1331	237	5	198(2–3):215–7	198(2–3):215–7	X
dti-1331	237	6	.	.	PUNCT
dti-1331	238	1	fischer	fischer	PROPN
dti-1331	238	2	,	,	PUNCT
dti-1331	238	3	p	p	NOUN
dti-1331	238	4	-	-	PUNCT
dti-1331	238	5	a.	a.	NOUN
dti-1331	238	6	,	,	PUNCT
dti-1331	238	7	jacobi	jacobi	PROPN
dti-1331	238	8	,	,	PUNCT
dti-1331	238	9	p.	p.	PROPN
dti-1331	238	10	,	,	PUNCT
dti-1331	238	11	schneider	schneider	PROPN
dti-1331	238	12	,	,	PUNCT
dti-1331	238	13	e.	e.	PROPN
dti-1331	238	14	et	et	PROPN
dti-1331	238	15	al	al	PROPN
dti-1331	238	16	.	.	PROPN
dti-1331	238	17	1977	1977	NUM
dti-1331	238	18	.	.	PUNCT
dti-1331	239	1	effects	effect	NOUN
dti-1331	239	2	of	of	ADP
dti-1331	239	3	intravenous	intravenous	ADJ
dti-1331	239	4	administration	administration	NOUN
dti-1331	239	5	of	of	ADP
dti-1331	239	6	memantine	memantine	NOUN
dti-1331	239	7	in	in	ADP
dti-1331	239	8	parkinsonian	parkinsonian	ADJ
dti-1331	239	9	patients	patient	NOUN
dti-1331	239	10	(	(	PUNCT
dti-1331	239	11	in	in	ADP
dti-1331	239	12	ger-23	ger-23	NOUN
dti-1331	239	13	man	man	NOUN
dti-1331	239	14	]	]	PUNCT
dti-1331	239	15	.	.	PUNCT
dti-1331	240	1	arzneimittelforschung	arzneimittelforschung	ADJ
dti-1331	240	2	,	,	PUNCT
dti-1331	240	3	27(ii)(7):1487–9	27(ii)(7):1487–9	NUM
dti-1331	240	4	.	.	PUNCT
dti-1331	241	1	floresco	floresco	PROPN
dti-1331	241	2	,	,	PUNCT
dti-1331	241	3	s.b	s.b	PROPN
dti-1331	241	4	.	.	PROPN
dti-1331	241	5	,	,	PUNCT
dti-1331	241	6	west	west	PROPN
dti-1331	241	7	,	,	PUNCT
dti-1331	241	8	a.r	a.r	PROPN
dti-1331	241	9	.	.	PROPN
dti-1331	241	10	,	,	PUNCT
dti-1331	241	11	ash	ash	PROPN
dti-1331	241	12	,	,	PUNCT
dti-1331	241	13	b.	b.	PROPN
dti-1331	241	14	,	,	PUNCT
dti-1331	241	15	moore	moore	PROPN
dti-1331	241	16	,	,	PUNCT
dti-1331	241	17	h.	h.	PROPN
dti-1331	241	18	and	and	CCONJ
dti-1331	241	19	grace	grace	NOUN
dti-1331	241	20	,	,	PUNCT
dti-1331	241	21	a.a	a.a	PROPN
dti-1331	241	22	.	.	PROPN
dti-1331	241	23	2003	2003	NUM
dti-1331	241	24	.	.	PUNCT
dti-1331	242	1	afferent	afferent	ADJ
dti-1331	242	2	modulation	modulation	NOUN
dti-1331	242	3	of	of	ADP
dti-1331	242	4	dopamine	dopamine	NOUN
dti-1331	242	5	neuron	neuron	NOUN
dti-1331	242	6	fi	fi	NOUN
dti-1331	242	7	ring	ring	NOUN
dti-1331	242	8	differentially	differentially	ADV
dti-1331	242	9	regulates	regulate	VERB
dti-1331	242	10	tonic	tonic	NOUN
dti-1331	242	11	and	and	CCONJ
dti-1331	242	12	phasic	phasic	ADJ
dti-1331	242	13	dopamine	dopamine	NOUN
dti-1331	242	14	transmission	transmission	NOUN
dti-1331	242	15	.	.	PUNCT
dti-1331	243	1	nat	nat	PROPN
dti-1331	243	2	.	.	PUNCT
dti-1331	244	1	neurosci	neurosci	PROPN
dti-1331	244	2	.	.	PUNCT
dti-1331	244	3	,	,	PUNCT
dti-1331	245	1	6:968–73	6:968–73	NOUN
dti-1331	245	2	.	.	PUNCT
dti-1331	245	3	84	84	NUM
dti-1331	245	4	moretti	moretti	PROPN
dti-1331	245	5	et	et	PROPN
dti-1331	245	6	al	al	PROPN
dti-1331	245	7	drug	drug	PROPN
dti-1331	245	8	target	target	NOUN
dti-1331	245	9	insights	insight	NOUN
dti-1331	245	10	2008:3	2008:3	NUM
dti-1331	245	11	francis	francis	PROPN
dti-1331	245	12	,	,	PUNCT
dti-1331	245	13	p.i	p.i	PROPN
dti-1331	245	14	.	.	PROPN
dti-1331	245	15	,	,	PUNCT
dti-1331	245	16	sims	sim	NOUN
dti-1331	245	17	,	,	PUNCT
dti-1331	245	18	n.r	n.r	PROPN
dti-1331	245	19	.	.	PROPN
dti-1331	245	20	,	,	PUNCT
dti-1331	245	21	procter	procter	PROPN
dti-1331	245	22	,	,	PUNCT
dti-1331	245	23	a.w	a.w	PROPN
dti-1331	245	24	.	.	PROPN
dti-1331	245	25	and	and	CCONJ
dti-1331	245	26	bowen	bowen	PROPN
dti-1331	245	27	,	,	PUNCT
dti-1331	245	28	d.m	d.m	PROPN
dti-1331	245	29	.	.	PROPN
dti-1331	245	30	1993	1993	NUM
dti-1331	245	31	.	.	PUNCT
dti-1331	246	1	cortical	cortical	ADJ
dti-1331	246	2	pyramidal	pyramidal	ADJ
dti-1331	246	3	neurone	neurone	NOUN
dti-1331	246	4	loss	loss	NOUN
dti-1331	246	5	may	may	AUX
dti-1331	246	6	cause	cause	VERB
dti-1331	246	7	glutamatergic	glutamatergic	ADJ
dti-1331	246	8	hypoactivity	hypoactivity	NOUN
dti-1331	246	9	and	and	CCONJ
dti-1331	246	10	cognitive	cognitive	ADJ
dti-1331	246	11	impairment	impairment	NOUN
dti-1331	246	12	in	in	ADP
dti-1331	246	13	alzheimer	alzheimer	PROPN
dti-1331	246	14	’s	’s	PART
dti-1331	246	15	disease	disease	NOUN
dti-1331	246	16	—	—	PUNCT
dti-1331	246	17	investigative	investigative	ADJ
dti-1331	246	18	and	and	CCONJ
dti-1331	246	19	therapeutic	therapeutic	ADJ
dti-1331	246	20	perspectives	perspective	NOUN
dti-1331	246	21	.	.	PUNCT
dti-1331	247	1	j.	j.	PROPN
dti-1331	247	2	neurochem	neurochem	PROPN
dti-1331	247	3	.	.	PUNCT
dti-1331	247	4	,	,	PUNCT
dti-1331	248	1	60:1589–604	60:1589–604	X
dti-1331	248	2	.	.	PUNCT
dti-1331	248	3	frankiewicz	frankiewicz	PROPN
dti-1331	248	4	,	,	PUNCT
dti-1331	248	5	t.	t.	NOUN
dti-1331	248	6	and	and	CCONJ
dti-1331	248	7	parsons	parson	NOUN
dti-1331	248	8	,	,	PUNCT
dti-1331	248	9	c.g	c.g	PROPN
dti-1331	248	10	.	.	PROPN
dti-1331	248	11	1999	1999	NUM
dti-1331	248	12	,	,	PUNCT
dti-1331	248	13	sep	sep	PROPN
dti-1331	248	14	.	.	PROPN
dti-1331	248	15	memantine	memantine	NOUN
dti-1331	248	16	restores	restore	VERB
dti-1331	248	17	long	long	ADJ
dti-1331	248	18	term	term	NOUN
dti-1331	248	19	potentiation	potentiation	NOUN
dti-1331	248	20	impaired	impair	VERB
dti-1331	248	21	by	by	ADP
dti-1331	248	22	tonic	tonic	NOUN
dti-1331	248	23	n	n	CCONJ
dti-1331	248	24	-	-	PUNCT
dti-1331	248	25	methyl	methyl	NOUN
dti-1331	248	26	-	-	PUNCT
dti-1331	248	27	d	d	NOUN
dti-1331	248	28	-	-	NOUN
dti-1331	248	29	aspartate	aspartate	ADJ
dti-1331	248	30	(	(	PUNCT
dti-1331	248	31	nmda	nmda	ADJ
dti-1331	248	32	)	)	PUNCT
dti-1331	248	33	receptor	receptor	NOUN
dti-1331	248	34	activation	activation	NOUN
dti-1331	248	35	following	follow	VERB
dti-1331	248	36	reduction	reduction	NOUN
dti-1331	248	37	of	of	ADP
dti-1331	248	38	mg2	mg2	PROPN
dti-1331	248	39	+	+	X
dti-1331	248	40	in	in	ADP
dti-1331	248	41	hippocampal	hippocampal	ADJ
dti-1331	248	42	slices	slice	NOUN
dti-1331	248	43	.	.	PUNCT
dti-1331	249	1	neuropharmacology	neuropharmacology	NOUN
dti-1331	249	2	,	,	PUNCT
dti-1331	249	3	38(9):1253–9	38(9):1253–9	PROPN
dti-1331	249	4	.	.	PUNCT
dti-1331	250	1	gardoni	gardoni	PROPN
dti-1331	250	2	,	,	PUNCT
dti-1331	250	3	f.	f.	PROPN
dti-1331	250	4	and	and	CCONJ
dti-1331	250	5	di	di	PROPN
dti-1331	250	6	luca	luca	PROPN
dti-1331	250	7	,	,	PUNCT
dti-1331	250	8	m.	m.	NOUN
dti-1331	250	9	2006	2006	NUM
dti-1331	250	10	.	.	PUNCT
dti-1331	251	1	new	new	ADJ
dti-1331	251	2	targets	target	NOUN
dti-1331	251	3	for	for	ADP
dti-1331	251	4	pharmacological	pharmacological	ADJ
dti-1331	251	5	intervention	intervention	NOUN
dti-1331	251	6	in	in	ADP
dti-1331	251	7	the	the	DET
dti-1331	251	8	glutamatergic	glutamatergic	ADJ
dti-1331	251	9	synapse	synapse	NOUN
dti-1331	251	10	.	.	PUNCT
dti-1331	252	1	eur	eur	PROPN
dti-1331	252	2	.	.	PUNCT
dti-1331	253	1	j.	j.	PROPN
dti-1331	253	2	pharmacol	pharmacol	PROPN
dti-1331	253	3	.	.	PROPN
dti-1331	253	4	,	,	PUNCT
dti-1331	253	5	545:2–10	545:2–10	X
dti-1331	253	6	.	.	PUNCT
dti-1331	253	7	giulian	giulian	PROPN
dti-1331	253	8	,	,	PUNCT
dti-1331	253	9	d.	d.	PROPN
dti-1331	253	10	,	,	PUNCT
dti-1331	253	11	haverkamp	haverkamp	PROPN
dti-1331	253	12	,	,	PUNCT
dti-1331	253	13	l.j	l.j	PROPN
dti-1331	253	14	.	.	PROPN
dti-1331	253	15	,	,	PUNCT
dti-1331	253	16	li	li	PROPN
dti-1331	253	17	,	,	PUNCT
dti-1331	253	18	l.	l.	PROPN
dti-1331	253	19	,	,	PUNCT
dti-1331	253	20	karshin	karshin	PROPN
dti-1331	253	21	,	,	PUNCT
dti-1331	253	22	w.l	w.l	PROPN
dti-1331	253	23	.	.	PROPN
dti-1331	253	24	,	,	PUNCT
dti-1331	253	25	yu	yu	PROPN
dti-1331	253	26	,	,	PUNCT
dti-1331	253	27	l.	l.	PROPN
dti-1331	253	28	,	,	PUNCT
dti-1331	253	29	tom	tom	PROPN
dti-1331	253	30	,	,	PUNCT
dti-1331	253	31	d.	d.	PROPN
dti-1331	253	32	,	,	PUNCT
dti-1331	253	33	li	li	PROPN
dti-1331	253	34	,	,	PUNCT
dti-1331	253	35	x.	x.	PROPN
dti-1331	253	36	and	and	CCONJ
dti-1331	253	37	kirkpatrick	kirkpatrick	PROPN
dti-1331	253	38	,	,	PUNCT
dti-1331	253	39	j.b	j.b	PROPN
dti-1331	253	40	.	.	PROPN
dti-1331	253	41	1995	1995	NUM
dti-1331	253	42	.	.	PUNCT
dti-1331	254	1	senile	senile	ADJ
dti-1331	254	2	plaques	plaque	NOUN
dti-1331	254	3	stimulate	stimulate	VERB
dti-1331	254	4	microglia	microglia	NOUN
dti-1331	254	5	to	to	PART
dti-1331	254	6	release	release	VERB
dti-1331	254	7	a	a	DET
dti-1331	254	8	neurotoxin	neurotoxin	NOUN
dti-1331	254	9	found	find	VERB
dti-1331	254	10	in	in	ADP
dti-1331	254	11	alzheimer	alzheimer	PROPN
dti-1331	254	12	brain	brain	NOUN
dti-1331	254	13	.	.	PUNCT
dti-1331	255	1	neurochem	neurochem	PROPN
dti-1331	255	2	.	.	PUNCT
dti-1331	256	1	int	int	NOUN
dti-1331	256	2	.	.	PUNCT
dti-1331	257	1	,	,	PUNCT
dti-1331	257	2	27:119–37	27:119–37	NOUN
dti-1331	257	3	.	.	PUNCT
dti-1331	258	1	giustizieri	giustizieri	PROPN
dti-1331	258	2	,	,	PUNCT
dti-1331	258	3	m.	m.	NOUN
dti-1331	258	4	,	,	PUNCT
dti-1331	258	5	cucchiaroni	cucchiaroni	NOUN
dti-1331	258	6	,	,	PUNCT
dti-1331	258	7	m.l	m.l	PROPN
dti-1331	258	8	.	.	PROPN
dti-1331	258	9	,	,	PUNCT
dti-1331	258	10	guatteo	guatteo	PROPN
dti-1331	258	11	,	,	PUNCT
dti-1331	258	12	e.	e.	PROPN
dti-1331	258	13	,	,	PUNCT
dti-1331	258	14	bernardi	bernardi	PROPN
dti-1331	258	15	,	,	PUNCT
dti-1331	258	16	g.	g.	PROPN
dti-1331	258	17	,	,	PUNCT
dti-1331	258	18	mercuri	mercuri	PROPN
dti-1331	258	19	,	,	PUNCT
dti-1331	258	20	n.b	n.b	PROPN
dti-1331	258	21	.	.	PROPN
dti-1331	258	22	and	and	CCONJ
dti-1331	258	23	berretta	berretta	PROPN
dti-1331	258	24	,	,	PUNCT
dti-1331	258	25	n.	n.	NOUN
dti-1331	258	26	2007	2007	NUM
dti-1331	258	27	,	,	PUNCT
dti-1331	258	28	may	may	AUX
dti-1331	258	29	11	11	NUM
dti-1331	258	30	.	.	PUNCT
dti-1331	259	1	memantine	memantine	PROPN
dti-1331	259	2	inhibits	inhibit	VERB
dti-1331	259	3	atp	atp	PROPN
dti-1331	259	4	-	-	PUNCT
dti-1331	259	5	dependent	dependent	ADJ
dti-1331	259	6	k+	k+	NOUN
dti-1331	259	7	conductances	conductance	NOUN
dti-1331	259	8	in	in	ADP
dti-1331	259	9	dopamine	dopamine	NOUN
dti-1331	259	10	neurons	neuron	NOUN
dti-1331	259	11	of	of	ADP
dti-1331	259	12	the	the	DET
dti-1331	259	13	rat	rat	NOUN
dti-1331	259	14	substantia	substantia	NOUN
dti-1331	259	15	nigra	nigra	PROPN
dti-1331	259	16	pars	par	NOUN
dti-1331	259	17	compacta	compacta	PROPN
dti-1331	259	18	jpet	jpet	PROPN
dti-1331	259	19	fast	fast	ADV
dti-1331	259	20	forward	forward	ADV
dti-1331	259	21	.	.	PUNCT
dti-1331	260	1	published	publish	VERB
dti-1331	260	2	on	on	ADP
dti-1331	260	3	,	,	PUNCT
dti-1331	260	4	as	as	ADP
dti-1331	260	5	doi:10.1124/	doi:10.1124/	PROPN
dti-1331	260	6	jpet.107.122036	jpet.107.122036	PROPN
dti-1331	260	7	.	.	PROPN
dti-1331	261	1	goodwin	goodwin	PROPN
dti-1331	261	2	,	,	PUNCT
dti-1331	261	3	j.l	j.l	PROPN
dti-1331	261	4	.	.	PROPN
dti-1331	261	5	,	,	PUNCT
dti-1331	261	6	demura	demura	PROPN
dti-1331	261	7	,	,	PUNCT
dti-1331	261	8	e.	e.	PROPN
dti-1331	261	9	and	and	CCONJ
dti-1331	261	10	cunnick	cunnick	PROPN
dti-1331	261	11	,	,	PUNCT
dti-1331	261	12	j.e	j.e	PROPN
dti-1331	261	13	.	.	PROPN
dti-1331	261	14	1995	1995	NUM
dti-1331	261	15	.	.	PUNCT
dti-1331	262	1	microglial	microglial	ADJ
dti-1331	262	2	release	release	NOUN
dti-1331	262	3	of	of	ADP
dti-1331	262	4	nitric	nitric	ADJ
dti-1331	262	5	oxide	oxide	NOUN
dti-1331	262	6	by	by	ADP
dti-1331	262	7	the	the	DET
dti-1331	262	8	synergistic	synergistic	ADJ
dti-1331	262	9	action	action	NOUN
dti-1331	262	10	of	of	ADP
dti-1331	262	11	beta	beta	NOUN
dti-1331	262	12	-	-	PUNCT
dti-1331	262	13	amyloid	amyloid	NOUN
dti-1331	262	14	and	and	CCONJ
dti-1331	262	15	ifn	ifn	PROPN
dti-1331	262	16	-	-	PUNCT
dti-1331	262	17	gamma	gamma	NOUN
dti-1331	262	18	.	.	PUNCT
dti-1331	263	1	brain	brain	NOUN
dti-1331	263	2	res	re	NOUN
dti-1331	263	3	.	.	PUNCT
dti-1331	263	4	,	,	PUNCT
dti-1331	263	5	692:207–14	692:207–14	PROPN
dti-1331	263	6	.	.	PUNCT
dti-1331	263	7	gorgiilii	gorgiilii	PROPN
dti-1331	263	8	,	,	PUNCT
dti-1331	263	9	a.	a.	NOUN
dti-1331	263	10	,	,	PUNCT
dti-1331	263	11	kins	kin	NOUN
dti-1331	263	12	,	,	PUNCT
dti-1331	263	13	t.	t.	PROPN
dti-1331	263	14	,	,	PUNCT
dti-1331	263	15	cobanoglu	cobanoglu	NOUN
dti-1331	263	16	,	,	PUNCT
dti-1331	263	17	s.	s.	PROPN
dti-1331	263	18	et	et	PROPN
dti-1331	263	19	al	al	PROPN
dti-1331	263	20	.	.	PROPN
dti-1331	263	21	2000	2000	NUM
dti-1331	263	22	.	.	PUNCT
dti-1331	264	1	reduction	reduction	NOUN
dti-1331	264	2	of	of	ADP
dti-1331	264	3	edema	edema	NOUN
dti-1331	264	4	and	and	CCONJ
dti-1331	264	5	infarction	infarction	NOUN
dti-1331	264	6	by	by	ADP
dti-1331	264	7	memantine	memantine	NOUN
dti-1331	264	8	and	and	CCONJ
dti-1331	264	9	mk-80l	mk-80l	NOUN
dti-1331	264	10	after	after	ADP
dti-1331	264	11	focal	focal	ADJ
dti-1331	264	12	cerebral	cerebral	ADJ
dti-1331	264	13	ischaemia	ischaemia	NOUN
dti-1331	264	14	and	and	CCONJ
dti-1331	264	15	reperfusion	reperfusion	NOUN
dti-1331	264	16	in	in	ADP
dti-1331	264	17	rat	rat	PROPN
dti-1331	264	18	.	.	PROPN
dti-1331	264	19	acta	acta	PROPN
dti-1331	264	20	.	.	PUNCT
dti-1331	265	1	neurochir	neurochir	NOUN
dti-1331	265	2	(	(	PUNCT
dti-1331	265	3	wien	wien	PROPN
dti-1331	265	4	)	)	PUNCT
dti-1331	265	5	,	,	PUNCT
dti-1331	265	6	142(11):1287–92	142(11):1287–92	NUM
dti-1331	265	7	.	.	PUNCT
dti-1331	266	1	hartmann	hartmann	PROPN
dti-1331	266	2	,	,	PUNCT
dti-1331	266	3	s.	s.	PROPN
dti-1331	266	4	and	and	CCONJ
dti-1331	266	5	mobius	mobius	PROPN
dti-1331	266	6	,	,	PUNCT
dti-1331	266	7	h.	h.	PROPN
dti-1331	266	8	2003	2003	NUM
dti-1331	266	9	.	.	PUNCT
dti-1331	267	1	tolerability	tolerability	NOUN
dti-1331	267	2	of	of	ADP
dti-1331	267	3	memantine	memantine	NOUN
dti-1331	267	4	in	in	ADP
dti-1331	267	5	combination	combination	NOUN
dti-1331	267	6	with	with	ADP
dti-1331	267	7	cholinesterase	cholinesterase	NOUN
dti-1331	267	8	inhibitors	inhibitor	NOUN
dti-1331	267	9	in	in	ADP
dti-1331	267	10	dementia	dementia	NOUN
dti-1331	267	11	therapy	therapy	NOUN
dti-1331	267	12	.	.	PUNCT
dti-1331	268	1	int	int	NOUN
dti-1331	268	2	.	.	PUNCT
dti-1331	269	1	clin	clin	PROPN
dti-1331	269	2	.	.	PUNCT
dti-1331	270	1	psychopharmacol	psychopharmacol	PROPN
dti-1331	270	2	.	.	PROPN
dti-1331	270	3	,	,	PUNCT
dti-1331	270	4	18:81–5	18:81–5	NOUN
dti-1331	270	5	.	.	PUNCT
dti-1331	271	1	heim	heim	PROPN
dti-1331	271	2	,	,	PUNCT
dti-1331	271	3	c.	c.	PROPN
dti-1331	271	4	and	and	CCONJ
dti-1331	271	5	sontag	sontag	NOUN
dti-1331	271	6	,	,	PUNCT
dti-1331	271	7	k.h	k.h	PROPN
dti-1331	271	8	.	.	PROPN
dti-1331	271	9	1995	1995	NUM
dti-1331	271	10	.	.	PUNCT
dti-1331	272	1	memantine	memantine	NOUN
dti-1331	272	2	prevents	prevent	VERB
dti-1331	272	3	progressive	progressive	ADJ
dti-1331	272	4	functional	functional	ADJ
dti-1331	272	5	neurodegeneration	neurodegeneration	NOUN
dti-1331	272	6	in	in	ADP
dti-1331	272	7	rats	rat	NOUN
dti-1331	272	8	.	.	PUNCT
dti-1331	273	1	j.	j.	PROPN
dti-1331	273	2	neura.l	neura.l	PROPN
dti-1331	273	3	transm	transm	PROPN
dti-1331	273	4	,	,	PUNCT
dti-1331	273	5	46(supp1):17–30	46(supp1):17–30	PROPN
dti-1331	273	6	.	.	PUNCT
dti-1331	274	1	jarvis	jarvis	PROPN
dti-1331	274	2	,	,	PUNCT
dti-1331	274	3	b.	b.	PROPN
dti-1331	274	4	and	and	CCONJ
dti-1331	274	5	figgitt	figgitt	ADJ
dti-1331	274	6	,	,	PUNCT
dti-1331	274	7	d.p	d.p	PROPN
dti-1331	274	8	.	.	PROPN
dti-1331	274	9	2003	2003	NUM
dti-1331	274	10	.	.	PUNCT
dti-1331	275	1	memantine	memantine	NOUN
dti-1331	275	2	.	.	PUNCT
dti-1331	276	1	drugs	drug	NOUN
dti-1331	276	2	and	and	CCONJ
dti-1331	276	3	aging	aging	NOUN
dti-1331	276	4	,	,	PUNCT
dti-1331	276	5	20(6):465–76	20(6):465–76	NUM
dti-1331	276	6	.	.	PUNCT
dti-1331	277	1	jones	jones	PROPN
dti-1331	277	2	,	,	PUNCT
dti-1331	277	3	r.w	r.w	PROPN
dti-1331	277	4	.	.	PROPN
dti-1331	277	5	,	,	PUNCT
dti-1331	277	6	bayer	bayer	PROPN
dti-1331	277	7	,	,	PUNCT
dti-1331	277	8	a.	a.	PROPN
dti-1331	277	9	,	,	PUNCT
dti-1331	277	10	inglis	inglis	PROPN
dti-1331	277	11	,	,	PUNCT
dti-1331	277	12	f.	f.	PROPN
dti-1331	277	13	et	et	PROPN
dti-1331	277	14	al	al	PROPN
dti-1331	277	15	.	.	PROPN
dti-1331	277	16	2007	2007	NUM
dti-1331	277	17	,	,	PUNCT
dti-1331	277	18	january	january	PROPN
dti-1331	277	19	.	.	PUNCT
dti-1331	278	1	safety	safety	NOUN
dti-1331	278	2	and	and	CCONJ
dti-1331	278	3	tolerability	tolerability	NOUN
dti-1331	278	4	of	of	ADP
dti-1331	278	5	once	once	ADV
dti-1331	278	6	-	-	PUNCT
dti-1331	278	7	daily	daily	ADJ
dti-1331	278	8	versus	versus	ADP
dti-1331	278	9	twice	twice	ADV
dti-1331	278	10	-	-	PUNCT
dti-1331	278	11	daily	daily	ADJ
dti-1331	278	12	memantine	memantine	NOUN
dti-1331	278	13	:	:	PUNCT
dti-1331	278	14	a	a	DET
dti-1331	278	15	randomised	randomised	ADJ
dti-1331	278	16	,	,	PUNCT
dti-1331	278	17	doubleblind	doubleblind	NOUN
dti-1331	278	18	study	study	NOUN
dti-1331	278	19	in	in	ADP
dti-1331	278	20	moderate	moderate	ADJ
dti-1331	278	21	to	to	ADP
dti-1331	278	22	severe	severe	ADJ
dti-1331	278	23	alzheimer	alzheimer	PROPN
dti-1331	278	24	’s	’s	PART
dti-1331	278	25	disease	disease	NOUN
dti-1331	278	26	.	.	PUNCT
dti-1331	279	1	int	int	NOUN
dti-1331	279	2	.	.	PUNCT
dti-1331	280	1	j.	j.	PROPN
dti-1331	280	2	geriatr	geriatr	PROPN
dti-1331	280	3	.	.	PUNCT
dti-1331	281	1	psychiatr	psychiatr	PROPN
dti-1331	281	2	.	.	PUNCT
dti-1331	281	3	,	,	PUNCT
dti-1331	281	4	http://www3.interscience.wiley.com/cgi–bin/	http://www3.interscience.wiley.com/cgi–bin/	NOUN
dti-1331	281	5	jhome/4294	jhome/4294	NOUN
dti-1331	281	6	.	.	PUNCT
dti-1331	282	1	keilhoff	keilhoff	PROPN
dti-1331	282	2	,	,	PUNCT
dti-1331	282	3	g.	g.	PROPN
dti-1331	282	4	and	and	CCONJ
dti-1331	282	5	wolf	wolf	PROPN
dti-1331	282	6	,	,	PUNCT
dti-1331	282	7	g.	g.	PROPN
dti-1331	282	8	1992	1992	NUM
dti-1331	282	9	,	,	PUNCT
dti-1331	282	10	sep	sep	PROPN
dti-1331	282	11	4	4	NUM
dti-1331	282	12	.	.	PUNCT
dti-1331	282	13	memantine	memantine	NOUN
dti-1331	282	14	prevents	prevent	VERB
dti-1331	282	15	quinolinic	quinolinic	ADJ
dti-1331	282	16	acid	acid	NOUN
dti-1331	282	17	-	-	PUNCT
dti-1331	282	18	induced	induce	VERB
dti-1331	282	19	hippocampal	hippocampal	ADJ
dti-1331	282	20	damage	damage	NOUN
dti-1331	282	21	.	.	PUNCT
dti-1331	283	1	eur	eur	PROPN
dti-1331	283	2	.	.	PUNCT
dti-1331	284	1	j.	j.	PROPN
dti-1331	284	2	pharmacol	pharmacol	PROPN
dti-1331	284	3	.	.	PUNCT
dti-1331	285	1	,	,	PUNCT
dti-1331	285	2	219(3):451–4	219(3):451–4	NUM
dti-1331	285	3	.	.	PUNCT
dti-1331	286	1	klegeris	klegeris	PROPN
dti-1331	286	2	,	,	PUNCT
dti-1331	286	3	a.	a.	NOUN
dti-1331	286	4	and	and	CCONJ
dti-1331	286	5	mcgeer	mcgeer	PROPN
dti-1331	286	6	,	,	PUNCT
dti-1331	286	7	p.l	p.l	PROPN
dti-1331	286	8	.	.	PROPN
dti-1331	286	9	1997	1997	NUM
dti-1331	286	10	.	.	PUNCT
dti-1331	287	1	beta	beta	NOUN
dti-1331	287	2	-	-	PUNCT
dti-1331	287	3	amyloid	amyloid	NOUN
dti-1331	287	4	protein	protein	NOUN
dti-1331	287	5	enhances	enhance	VERB
dti-1331	287	6	macrophage	macrophage	ADJ
dti-1331	287	7	production	production	NOUN
dti-1331	287	8	of	of	ADP
dti-1331	287	9	oxygen	oxygen	NOUN
dti-1331	287	10	free	free	ADJ
dti-1331	287	11	radicals	radical	NOUN
dti-1331	287	12	and	and	CCONJ
dti-1331	287	13	glutamate	glutamate	NOUN
dti-1331	287	14	.	.	PUNCT
dti-1331	288	1	j.	j.	PROPN
dti-1331	288	2	neurosci	neurosci	PROPN
dti-1331	288	3	.	.	PUNCT
dti-1331	289	1	res	re	NOUN
dti-1331	289	2	.	.	PROPN
dti-1331	289	3	,	,	PUNCT
dti-1331	289	4	49:229–35	49:229–35	NOUN
dti-1331	289	5	.	.	PUNCT
dti-1331	290	1	knopman	knopman	PROPN
dti-1331	290	2	,	,	PUNCT
dti-1331	290	3	d.	d.	PROPN
dti-1331	290	4	2005	2005	NUM
dti-1331	290	5	.	.	PUNCT
dti-1331	291	1	san	san	PROPN
dti-1331	291	2	francisco	francisco	PROPN
dti-1331	291	3	.	.	PUNCT
dti-1331	292	1	where	where	SCONJ
dti-1331	292	2	we	we	PRON
dti-1331	292	3	stand	stand	VERB
dti-1331	292	4	with	with	ADP
dti-1331	292	5	symptomatic	symptomatic	ADJ
dti-1331	292	6	treatments	treatment	NOUN
dti-1331	292	7	for	for	ADP
dti-1331	292	8	alzheimer	alzheimer	PROPN
dti-1331	292	9	disease	disease	PROPN
dti-1331	292	10	.	.	PUNCT
dti-1331	293	1	american	american	PROPN
dti-1331	293	2	academy	academy	PROPN
dti-1331	293	3	of	of	ADP
dti-1331	293	4	neurology	neurology	PROPN
dti-1331	293	5	,	,	PUNCT
dti-1331	293	6	1kp003:1–34	1kp003:1–34	NUM
dti-1331	293	7	.	.	PUNCT
dti-1331	293	8	krieglstein	krieglstein	PROPN
dti-1331	293	9	,	,	PUNCT
dti-1331	293	10	j.	j.	PROPN
dti-1331	293	11	,	,	PUNCT
dti-1331	293	12	lippert	lippert	PROPN
dti-1331	293	13	,	,	PUNCT
dti-1331	293	14	k.	k.	PROPN
dti-1331	293	15	and	and	CCONJ
dti-1331	293	16	poch	poch	PROPN
dti-1331	293	17	,	,	PUNCT
dti-1331	293	18	g.	g.	PROPN
dti-1331	293	19	1996	1996	NUM
dti-1331	293	20	.	.	PUNCT
dti-1331	294	1	apparent	apparent	ADJ
dti-1331	294	2	independent	independent	ADJ
dti-1331	294	3	action	action	NOUN
dti-1331	294	4	of	of	ADP
dti-1331	294	5	nimodipine	nimodipine	ADJ
dti-1331	294	6	and	and	CCONJ
dti-1331	294	7	glutamate	glutamate	VERB
dti-1331	294	8	antagonists	antagonist	NOUN
dti-1331	294	9	to	to	PART
dti-1331	294	10	protect	protect	VERB
dti-1331	294	11	cultured	cultured	ADJ
dti-1331	294	12	neurons	neuron	NOUN
dti-1331	294	13	against	against	ADP
dti-1331	294	14	glutamate	glutamate	NOUN
dti-1331	294	15	-	-	PUNCT
dti-1331	294	16	induced	induce	VERB
dti-1331	294	17	damage	damage	NOUN
dti-1331	294	18	.	.	PUNCT
dti-1331	295	1	neuropharmacology	neuropharmacology	NOUN
dti-1331	295	2	,	,	PUNCT
dti-1331	295	3	35(no	35(no	NUM
dti-1331	295	4	.	.	PUNCT
dti-1331	296	1	j2):1737–42	j2):1737–42	PROPN
dti-1331	296	2	.	.	PROPN
dti-1331	296	3	kucheryanu	kucheryanu	PROPN
dti-1331	296	4	,	,	PUNCT
dti-1331	296	5	v.g	v.g	PROPN
dti-1331	296	6	.	.	PROPN
dti-1331	296	7	and	and	CCONJ
dti-1331	296	8	kryzhanovskii	kryzhanovskii	PROPN
dti-1331	296	9	,	,	PUNCT
dti-1331	296	10	g.n	g.n	PROPN
dti-1331	296	11	.	.	PROPN
dti-1331	296	12	2000	2000	NUM
dti-1331	296	13	.	.	PUNCT
dti-1331	297	1	effect	effect	NOUN
dti-1331	297	2	of	of	ADP
dti-1331	297	3	glutamate	glutamate	NOUN
dti-1331	297	4	and	and	CCONJ
dti-1331	297	5	antagonists	antagonist	NOUN
dti-1331	297	6	of	of	ADP
dti-1331	297	7	nmethyld	nmethyld	NOUN
dti-1331	297	8	-	-	PUNCT
dti-1331	297	9	aspartate	aspartate	NOUN
dti-1331	297	10	receptors	receptor	NOUN
dti-1331	297	11	on	on	ADP
dti-1331	297	12	experimental	experimental	ADJ
dti-1331	297	13	parkinsonian	parkinsonian	ADJ
dti-1331	297	14	syndrome	syndrome	NOUN
dti-1331	297	15	in	in	ADP
dti-1331	297	16	rats	rat	NOUN
dti-1331	297	17	.	.	PUNCT
dti-1331	298	1	bull	bull	NOUN
dti-1331	298	2	exp	exp	NOUN
dti-1331	298	3	.	.	PUNCT
dti-1331	299	1	biol	biol	PROPN
dti-1331	299	2	.	.	PUNCT
dti-1331	300	1	med	med	PROPN
dti-1331	300	2	.	.	PROPN
dti-1331	300	3	,	,	PUNCT
dti-1331	300	4	130:629–32	130:629–32	NUM
dti-1331	300	5	.	.	PUNCT
dti-1331	301	1	li	li	PROPN
dti-1331	301	2	,	,	PUNCT
dti-1331	301	3	s.	s.	PROPN
dti-1331	301	4	,	,	PUNCT
dti-1331	301	5	mallory	mallory	PROPN
dti-1331	301	6	,	,	PUNCT
dti-1331	301	7	m.	m.	NOUN
dti-1331	301	8	,	,	PUNCT
dti-1331	301	9	alford	alford	PROPN
dti-1331	301	10	,	,	PUNCT
dti-1331	301	11	m.	m.	NOUN
dti-1331	301	12	,	,	PUNCT
dti-1331	301	13	tanaka	tanaka	PROPN
dti-1331	301	14	,	,	PUNCT
dti-1331	301	15	s.	s.	PROPN
dti-1331	301	16	and	and	CCONJ
dti-1331	301	17	masliah	masliah	PROPN
dti-1331	301	18	,	,	PUNCT
dti-1331	301	19	e.	e.	PROPN
dti-1331	301	20	1997	1997	NUM
dti-1331	301	21	.	.	PUNCT
dti-1331	302	1	glutamate	glutamate	VERB
dti-1331	302	2	transporter	transporter	NOUN
dti-1331	302	3	alterations	alteration	NOUN
dti-1331	302	4	in	in	ADP
dti-1331	302	5	alzheimer	alzheimer	PROPN
dti-1331	302	6	disease	disease	NOUN
dti-1331	302	7	are	be	AUX
dti-1331	302	8	possibly	possibly	ADV
dti-1331	302	9	associated	associate	VERB
dti-1331	302	10	with	with	ADP
dti-1331	302	11	abnormal	abnormal	ADJ
dti-1331	302	12	app	app	NOUN
dti-1331	302	13	expression	expression	NOUN
dti-1331	302	14	.	.	PUNCT
dti-1331	303	1	j.	j.	PROPN
dti-1331	303	2	neuropathal	neuropathal	PROPN
dti-1331	303	3	.	.	PUNCT
dti-1331	304	1	exp	exp	NOUN
dti-1331	304	2	.	.	PUNCT
dti-1331	305	1	neurol	neurol	PROPN
dti-1331	305	2	.	.	PUNCT
dti-1331	306	1	,	,	PUNCT
dti-1331	307	1	56:901–11	56:901–11	ADJ
dti-1331	307	2	.	.	PUNCT
dti-1331	308	1	liss	liss	PROPN
dti-1331	308	2	,	,	PUNCT
dti-1331	308	3	b.	b.	PROPN
dti-1331	308	4	,	,	PUNCT
dti-1331	308	5	haeckel	haeckel	PROPN
dti-1331	308	6	,	,	PUNCT
dti-1331	308	7	o.	o.	PROPN
dti-1331	308	8	,	,	PUNCT
dti-1331	308	9	wildmann	wildmann	PROPN
dti-1331	308	10	,	,	PUNCT
dti-1331	308	11	j.	j.	PROPN
dti-1331	308	12	,	,	PUNCT
dti-1331	308	13	miki	miki	PROPN
dti-1331	308	14	,	,	PUNCT
dti-1331	308	15	t.	t.	PROPN
dti-1331	308	16	,	,	PUNCT
dti-1331	308	17	seino	seino	PROPN
dti-1331	308	18	,	,	PUNCT
dti-1331	308	19	s.	s.	PROPN
dti-1331	308	20	and	and	CCONJ
dti-1331	308	21	roeper	roeper	PROPN
dti-1331	308	22	,	,	PUNCT
dti-1331	308	23	j.	j.	PROPN
dti-1331	308	24	2005	2005	NUM
dti-1331	308	25	.	.	PUNCT
dti-1331	309	1	k	k	X
dti-1331	309	2	-	-	PUNCT
dti-1331	309	3	atp	atp	PROPN
dti-1331	309	4	channels	channel	NOUN
dti-1331	309	5	promote	promote	VERB
dti-1331	309	6	the	the	DET
dti-1331	309	7	differential	differential	ADJ
dti-1331	309	8	degeneration	degeneration	NOUN
dti-1331	309	9	of	of	ADP
dti-1331	309	10	dopaminergic	dopaminergic	ADJ
dti-1331	309	11	midbrain	midbrain	NOUN
dti-1331	309	12	neurons	neuron	NOUN
dti-1331	309	13	.	.	PUNCT
dti-1331	310	1	nat	nat	PROPN
dti-1331	310	2	.	.	PUNCT
dti-1331	311	1	neurosci	neurosci	PROPN
dti-1331	311	2	.	.	PUNCT
dti-1331	311	3	,	,	PUNCT
dti-1331	311	4	8:1742–51	8:1742–51	PROPN
dti-1331	311	5	.	.	PUNCT
dti-1331	311	6	lundbeck	lundbeck	NOUN
dti-1331	311	7	als	als	NOUN
dti-1331	311	8	,	,	PUNCT
dti-1331	311	9	h.	h.	PROPN
dti-1331	311	10	2002	2002	NUM
dti-1331	311	11	.	.	PUNCT
dti-1331	312	1	summary	summary	NOUN
dti-1331	312	2	of	of	ADP
dti-1331	312	3	product	product	NOUN
dti-1331	312	4	characteristics	characteristic	NOUN
dti-1331	312	5	.	.	PUNCT
dti-1331	313	1	ebixa	ebixa	PROPN
dti-1331	313	2	(	(	PUNCT
dti-1331	313	3	memantine	memantine	ADJ
dti-1331	313	4	hydrochloride	hydrochloride	NOUN
dti-1331	313	5	)	)	PUNCT
dti-1331	313	6	.	.	PUNCT
dti-1331	314	1	h.	h.	PROPN
dti-1331	314	2	lundbeck	lundbeck	PROPN
dti-1331	314	3	ais	ais	PROPN
dti-1331	314	4	,	,	PUNCT
dti-1331	314	5	valby	valby	NOUN
dti-1331	314	6	,	,	PUNCT
dti-1331	314	7	denmark	denmark	NOUN
dti-1331	314	8	l–13	l–13	PROPN
dti-1331	314	9	.	.	PUNCT
dti-1331	315	1	mattson	mattson	PROPN
dti-1331	315	2	,	,	PUNCT
dti-1331	315	3	m.p	m.p	PROPN
dti-1331	315	4	.	.	PROPN
dti-1331	315	5	,	,	PUNCT
dti-1331	315	6	cheng	cheng	PROPN
dti-1331	315	7	,	,	PUNCT
dti-1331	315	8	b.	b.	PROPN
dti-1331	315	9	,	,	PUNCT
dti-1331	315	10	davis	davis	PROPN
dti-1331	315	11	,	,	PUNCT
dti-1331	315	12	d.	d.	PROPN
dti-1331	315	13	,	,	PUNCT
dti-1331	315	14	bryant	bryant	PROPN
dti-1331	315	15	,	,	PUNCT
dti-1331	315	16	k.	k.	PROPN
dti-1331	315	17	,	,	PUNCT
dti-1331	315	18	lieberburg	lieberburg	PROPN
dti-1331	315	19	,	,	PUNCT
dti-1331	315	20	1	1	NUM
dti-1331	315	21	and	and	CCONJ
dti-1331	315	22	rydel	rydel	PROPN
dti-1331	315	23	,	,	PUNCT
dti-1331	315	24	r.e	r.e	PROPN
dti-1331	315	25	.	.	PROPN
dti-1331	315	26	1992	1992	NUM
dti-1331	315	27	.	.	PUNCT
dti-1331	316	1	beta	beta	NOUN
dti-1331	316	2	-	-	PUNCT
dti-1331	316	3	amyloid	amyloid	NOUN
dti-1331	316	4	peptides	peptide	NOUN
dti-1331	316	5	destabilize	destabilize	VERB
dti-1331	316	6	calcium	calcium	NOUN
dti-1331	316	7	homeostasis	homeostasis	NOUN
dti-1331	316	8	and	and	CCONJ
dti-1331	316	9	render	render	VERB
dti-1331	316	10	human	human	ADJ
dti-1331	316	11	cortical	cortical	ADJ
dti-1331	316	12	neurons	neuron	NOUN
dti-1331	316	13	vulnerable	vulnerable	ADJ
dti-1331	316	14	to	to	ADP
dti-1331	316	15	excitotoxicity	excitotoxicity	NOUN
dti-1331	316	16	.	.	PUNCT
dti-1331	317	1	j.	j.	PROPN
dti-1331	317	2	neurosci	neurosci	PROPN
dti-1331	317	3	.	.	PROPN
dti-1331	317	4	,	,	PUNCT
dti-1331	317	5	12:376–89	12:376–89	PROPN
dti-1331	317	6	.	.	PUNCT
dti-1331	318	1	mcshane	mcshane	PROPN
dti-1331	318	2	,	,	PUNCT
dti-1331	318	3	r.	r.	PROPN
dti-1331	318	4	,	,	PUNCT
dti-1331	318	5	areosa	areosa	NOUN
dti-1331	318	6	sastre	sastre	NOUN
dti-1331	318	7	,	,	PUNCT
dti-1331	318	8	a.	a.	NOUN
dti-1331	318	9	and	and	CCONJ
dti-1331	318	10	minakaran	minakaran	VERB
dti-1331	318	11	,	,	PUNCT
dti-1331	318	12	n.	n.	NOUN
dti-1331	318	13	memantine	memantine	NOUN
dti-1331	318	14	for	for	ADP
dti-1331	318	15	dementiathe	dementiathe	DET
dti-1331	318	16	cochrane	cochrane	PROPN
dti-1331	318	17	library	library	NOUN
dti-1331	318	18	the	the	DET
dti-1331	318	19	cochrane	cochrane	PROPN
dti-1331	318	20	database	database	NOUN
dti-1331	318	21	of	of	ADP
dti-1331	318	22	systematic	systematic	ADJ
dti-1331	318	23	reviews	review	NOUN
dti-1331	318	24	2007	2007	NUM
dti-1331	318	25	issue	issue	NOUN
dti-1331	318	26	1	1	NUM
dti-1331	318	27	.	.	PUNCT
dti-1331	319	1	merello	merello	PROPN
dti-1331	319	2	,	,	PUNCT
dti-1331	319	3	m.	m.	NOUN
dti-1331	319	4	,	,	PUNCT
dti-1331	319	5	nouzeilles	nouzeille	NOUN
dti-1331	319	6	,	,	PUNCT
dti-1331	319	7	m.i	m.i	PROPN
dti-1331	319	8	.	.	PROPN
dti-1331	319	9	,	,	PUNCT
dti-1331	319	10	cammarota	cammarota	NOUN
dti-1331	319	11	,	,	PUNCT
dti-1331	319	12	a.	a.	NOUN
dti-1331	319	13	and	and	CCONJ
dti-1331	319	14	leiguarda	leiguarda	PROPN
dti-1331	319	15	,	,	PUNCT
dti-1331	319	16	r.	r.	PROPN
dti-1331	319	17	1999	1999	NUM
dti-1331	319	18	.	.	PUNCT
dti-1331	320	1	effect	effect	NOUN
dti-1331	320	2	of	of	ADP
dti-1331	320	3	memantine	memantine	NOUN
dti-1331	320	4	(	(	PUNCT
dti-1331	320	5	nmda	nmda	ADJ
dti-1331	320	6	antagonist	antagonist	NOUN
dti-1331	320	7	)	)	PUNCT
dti-1331	320	8	on	on	ADP
dti-1331	320	9	parkinson	parkinson	NOUN
dti-1331	320	10	’s	’s	PART
dti-1331	320	11	disease	disease	NOUN
dti-1331	320	12	:	:	PUNCT
dti-1331	320	13	a	a	DET
dti-1331	320	14	doubleblind	doubleblind	NOUN
dti-1331	320	15	crossover	crossover	VERB
dti-1331	320	16	randomized	randomized	ADJ
dti-1331	320	17	study	study	NOUN
dti-1331	320	18	.	.	PUNCT
dti-1331	321	1	clin	clin	PROPN
dti-1331	321	2	.	.	PUNCT
dti-1331	322	1	neuropharmacol	neuropharmacol	PROPN
dti-1331	322	2	.	.	PUNCT
dti-1331	322	3	,	,	PUNCT
dti-1331	323	1	22:273–6	22:273–6	NUM
dti-1331	323	2	.	.	PUNCT
dti-1331	324	1	mortimer	mortimer	PROPN
dti-1331	324	2	,	,	PUNCT
dti-1331	324	3	j.a	j.a	PROPN
dti-1331	324	4	.	.	PROPN
dti-1331	324	5	,	,	PUNCT
dti-1331	324	6	vanduijn	vanduijn	PROPN
dti-1331	324	7	,	,	PUNCT
dti-1331	324	8	c.m	c.m	PROPN
dti-1331	324	9	.	.	PROPN
dti-1331	324	10	,	,	PUNCT
dti-1331	324	11	chandra	chandra	PROPN
dti-1331	324	12	,	,	PUNCT
dti-1331	324	13	v.	v.	ADV
dti-1331	324	14	,	,	PUNCT
dti-1331	324	15	fratiglioni	fratiglioni	PROPN
dti-1331	324	16	,	,	PUNCT
dti-1331	324	17	l.	l.	PROPN
dti-1331	324	18	,	,	PUNCT
dti-1331	324	19	graves	grave	NOUN
dti-1331	324	20	,	,	PUNCT
dti-1331	324	21	a.b	a.b	PROPN
dti-1331	324	22	.	.	PROPN
dti-1331	324	23	,	,	PUNCT
dti-1331	324	24	heyman	heyman	PROPN
dti-1331	324	25	,	,	PUNCT
dti-1331	324	26	a.	a.	PROPN
dti-1331	324	27	,	,	PUNCT
dti-1331	324	28	jorm	jorm	NOUN
dti-1331	324	29	,	,	PUNCT
dti-1331	324	30	a.e	a.e	PROPN
dti-1331	324	31	.	.	PROPN
dti-1331	324	32	,	,	PUNCT
dti-1331	324	33	kokmen	kokman	NOUN
dti-1331	324	34	,	,	PUNCT
dti-1331	324	35	e.	e.	PROPN
dti-1331	324	36	,	,	PUNCT
dti-1331	324	37	kondo	kondo	PROPN
dti-1331	324	38	,	,	PUNCT
dti-1331	324	39	k.	k.	PROPN
dti-1331	324	40	,	,	PUNCT
dti-1331	324	41	rocca	rocca	PROPN
dti-1331	324	42	,	,	PUNCT
dti-1331	324	43	w.a	w.a	PROPN
dti-1331	324	44	.	.	PROPN
dti-1331	324	45	,	,	PUNCT
dti-1331	324	46	shalat	shalat	PROPN
dti-1331	324	47	,	,	PUNCT
dti-1331	324	48	s.l	s.l	PROPN
dti-1331	324	49	.	.	PROPN
dti-1331	324	50	,	,	PUNCT
dti-1331	324	51	soinien	soinien	PROPN
dti-1331	324	52	,	,	PUNCT
dti-1331	324	53	s.l	s.l	PROPN
dti-1331	324	54	.	.	PROPN
dti-1331	324	55	and	and	CCONJ
dti-1331	324	56	hofman	hofman	PROPN
dti-1331	324	57	,	,	PUNCT
dti-1331	324	58	a.	a.	NOUN
dti-1331	324	59	1991	1991	NUM
dti-1331	324	60	.	.	PUNCT
dti-1331	325	1	head	head	NOUN
dti-1331	325	2	trauma	trauma	NOUN
dti-1331	325	3	as	as	ADP
dti-1331	325	4	a	a	DET
dti-1331	325	5	risk	risk	NOUN
dti-1331	325	6	factor	factor	NOUN
dti-1331	325	7	for	for	ADP
dti-1331	325	8	alzheimer	alzheimer	PROPN
dti-1331	325	9	’s	’s	PART
dti-1331	325	10	disease	disease	NOUN
dti-1331	325	11	:	:	PUNCT
dti-1331	325	12	a	a	DET
dti-1331	325	13	collaborative	collaborative	ADJ
dti-1331	325	14	re	re	NOUN
dti-1331	325	15	-	-	NOUN
dti-1331	325	16	analysis	analysis	NOUN
dti-1331	325	17	of	of	ADP
dti-1331	325	18	case	case	NOUN
dti-1331	325	19	control	control	NOUN
dti-1331	325	20	studies	study	NOUN
dti-1331	325	21	.	.	PUNCT
dti-1331	326	1	int	int	NOUN
dti-1331	326	2	.	.	PUNCT
dti-1331	327	1	j.	j.	PROPN
dti-1331	327	2	epidemiol	epidemiol	PROPN
dti-1331	327	3	.	.	PROPN
dti-1331	327	4	,	,	PUNCT
dti-1331	327	5	20(suppl	20(suppl	NUM
dti-1331	327	6	2):s28	2):s28	NUM
dti-1331	327	7	–	–	PUNCT
dti-1331	327	8	s35	s35	PROPN
dti-1331	327	9	.	.	PUNCT
dti-1331	327	10	orgogozo	orgogozo	PROPN
dti-1331	327	11	,	,	PUNCT
dti-1331	327	12	j.m	j.m	PROPN
dti-1331	327	13	.	.	PROPN
dti-1331	327	14	,	,	PUNCT
dti-1331	327	15	rigaud	rigaud	NOUN
dti-1331	327	16	,	,	PUNCT
dti-1331	327	17	a.s	a.s	PROPN
dti-1331	327	18	.	.	PROPN
dti-1331	327	19	,	,	PUNCT
dti-1331	327	20	stoffl	stoffl	PROPN
dti-1331	327	21	er	er	INTJ
dti-1331	327	22	,	,	PUNCT
dti-1331	327	23	a.	a.	PROPN
dti-1331	327	24	,	,	PUNCT
dti-1331	327	25	mobius	mobius	PROPN
dti-1331	327	26	,	,	PUNCT
dti-1331	327	27	h.j	h.j	PROPN
dti-1331	327	28	.	.	PROPN
dti-1331	327	29	and	and	CCONJ
dti-1331	327	30	forette	forette	PROPN
dti-1331	327	31	,	,	PUNCT
dti-1331	327	32	f.	f.	PROPN
dti-1331	327	33	2002	2002	NUM
dti-1331	327	34	.	.	PUNCT
dti-1331	328	1	effi	effi	PROPN
dti-1331	328	2	cacy	cacy	PROPN
dti-1331	328	3	and	and	CCONJ
dti-1331	328	4	safety	safety	NOUN
dti-1331	328	5	of	of	ADP
dti-1331	328	6	memantine	memantine	NOUN
dti-1331	328	7	in	in	ADP
dti-1331	328	8	patients	patient	NOUN
dti-1331	328	9	with	with	ADP
dti-1331	328	10	mild	mild	ADJ
dti-1331	328	11	to	to	ADP
dti-1331	328	12	moderate	moderate	ADJ
dti-1331	328	13	vascular	vascular	ADJ
dti-1331	328	14	dementia	dementia	NOUN
dti-1331	328	15	.	.	PUNCT
dti-1331	329	1	a	a	DET
dti-1331	329	2	randomized	randomized	ADJ
dti-1331	329	3	,	,	PUNCT
dti-1331	329	4	placebo	placebo	NOUN
dti-1331	329	5	-	-	PUNCT
dti-1331	329	6	controlled	control	VERB
dti-1331	329	7	trial	trial	NOUN
dti-1331	329	8	(	(	PUNCT
dti-1331	329	9	mmm	mmm	NOUN
dti-1331	329	10	300	300	NUM
dti-1331	329	11	)	)	PUNCT
dti-1331	329	12	stroke	stroke	NOUN
dti-1331	329	13	33:1834–9	33:1834–9	NUM
dti-1331	329	14	.	.	PUNCT
dti-1331	330	1	parsons	parson	NOUN
dti-1331	330	2	,	,	PUNCT
dti-1331	330	3	c.g	c.g	PROPN
dti-1331	330	4	.	.	PROPN
dti-1331	330	5	,	,	PUNCT
dti-1331	330	6	gruner	gruner	PROPN
dti-1331	330	7	,	,	PUNCT
dti-1331	330	8	r.	r.	PROPN
dti-1331	330	9	,	,	PUNCT
dti-1331	330	10	rozental	rozental	NOUN
dti-1331	330	11	,	,	PUNCT
dti-1331	330	12	j.	j.	PROPN
dti-1331	330	13	et	et	PROPN
dti-1331	330	14	al	al	PROPN
dti-1331	330	15	.	.	PROPN
dti-1331	330	16	1993	1993	NUM
dti-1331	330	17	,	,	PUNCT
dti-1331	330	18	dec	dec	PROPN
dti-1331	330	19	.	.	PROPN
dti-1331	330	20	patch	patch	PROPN
dti-1331	330	21	clamp	clamp	NOUN
dti-1331	330	22	studies	study	NOUN
dti-1331	330	23	on	on	ADP
dti-1331	330	24	the	the	DET
dti-1331	330	25	kinetics	kinetic	NOUN
dti-1331	330	26	and	and	CCONJ
dti-1331	330	27	selectivity	selectivity	NOUN
dti-1331	330	28	of	of	ADP
dti-1331	330	29	n.-methyl	n.-methyl	NOUN
dti-1331	330	30	-	-	PUNCT
dti-1331	330	31	d	d	ADJ
dti-1331	330	32	aspartate	aspartate	NOUN
dti-1331	330	33	receptor	receptor	NOUN
dti-1331	330	34	antagonism	antagonism	NOUN
dti-1331	330	35	by	by	ADP
dti-1331	330	36	memantine	memantine	NOUN
dti-1331	330	37	(	(	PUNCT
dti-1331	330	38	l	l	NOUN
dti-1331	330	39	-	-	PUNCT
dti-1331	330	40	amino-3,5	amino-3,5	NOUN
dti-1331	330	41	-	-	PUNCT
dti-1331	330	42	dimethyjadamantan	dimethyjadamantan	ADJ
dti-1331	330	43	)	)	PUNCT
dti-1331	330	44	.	.	PUNCT
dti-1331	331	1	neuropharmacology	neuropharmacology	NOUN
dti-1331	331	2	,	,	PUNCT
dti-1331	331	3	32(12):1337–50	32(12):1337–50	NUM
dti-1331	331	4	.	.	PUNCT
dti-1331	332	1	parsons	parson	NOUN
dti-1331	332	2	,	,	PUNCT
dti-1331	332	3	c.g	c.g	PROPN
dti-1331	332	4	.	.	PROPN
dti-1331	332	5	,	,	PUNCT
dti-1331	332	6	danysz	danysz	PROPN
dti-1331	332	7	,	,	PUNCT
dti-1331	332	8	w.	w.	NOUN
dti-1331	332	9	and	and	CCONJ
dti-1331	332	10	quack	quack	INTJ
dti-1331	332	11	,	,	PUNCT
dti-1331	332	12	g.	g.	PROPN
dti-1331	332	13	1998	1998	NUM
dti-1331	332	14	.	.	PUNCT
dti-1331	333	1	glutamate	glutamate	VERB
dti-1331	333	2	in	in	ADP
dti-1331	333	3	cns	cns	NOUN
dti-1331	333	4	disorders	disorder	NOUN
dti-1331	333	5	as	as	ADP
dti-1331	333	6	a	a	DET
dti-1331	333	7	target	target	NOUN
dti-1331	333	8	for	for	ADP
dti-1331	333	9	drug	drug	NOUN
dti-1331	333	10	development	development	NOUN
dti-1331	333	11	.	.	PUNCT
dti-1331	334	1	an	an	DET
dti-1331	334	2	update	update	NOUN
dti-1331	334	3	.	.	PUNCT
dti-1331	335	1	drug	drug	NOUN
dti-1331	335	2	news	news	NOUN
dti-1331	335	3	perspect	perspect	NOUN
dti-1331	335	4	,	,	PUNCT
dti-1331	335	5	11:523–69	11:523–69	PROPN
dti-1331	335	6	.	.	PUNCT
dti-1331	335	7	pellegrini	pellegrini	PROPN
dti-1331	335	8	,	,	PUNCT
dti-1331	335	9	j.w	j.w	PROPN
dti-1331	335	10	.	.	PROPN
dti-1331	335	11	and	and	CCONJ
dti-1331	335	12	lipton	lipton	PROPN
dti-1331	335	13	,	,	PUNCT
dti-1331	335	14	s.a	s.a	PROPN
dti-1331	335	15	.	.	PUNCT
dti-1331	336	1	l993	l993	PROPN
dti-1331	336	2	.	.	PROPN
dti-1331	336	3	delayed	delay	VERB
dti-1331	336	4	administration	administration	NOUN
dti-1331	336	5	of	of	ADP
dti-1331	336	6	memantine	memantine	NOUN
dti-1331	336	7	prevents	prevent	VERB
dti-1331	336	8	n	n	CCONJ
dti-1331	336	9	-	-	PUNCT
dti-1331	336	10	methyl	methyl	NOUN
dti-1331	336	11	-	-	PUNCT
dti-1331	336	12	d	d	NOUN
dti-1331	336	13	-	-	PUNCT
dti-1331	336	14	aspartate	aspartate	ADJ
dti-1331	336	15	receptor	receptor	NOUN
dti-1331	336	16	-	-	PUNCT
dti-1331	336	17	mediated	mediate	VERB
dti-1331	336	18	neurotoxicity	neurotoxicity	NOUN
dti-1331	336	19	.	.	PUNCT
dti-1331	337	1	ann	ann	PROPN
dti-1331	337	2	.	.	PUNCT
dti-1331	338	1	neurol	neurol	PROPN
dti-1331	338	2	.	.	PUNCT
dti-1331	338	3	,	,	PUNCT
dti-1331	339	1	33(4):403–7	33(4):403–7	NUM
dti-1331	339	2	.	.	PUNCT
dti-1331	340	1	phillips	phillips	PROPN
dti-1331	340	2	,	,	PUNCT
dti-1331	340	3	p.e	p.e	PROPN
dti-1331	340	4	.	.	PROPN
dti-1331	340	5	,	,	PUNCT
dti-1331	340	6	stuber	stuber	PROPN
dti-1331	340	7	,	,	PUNCT
dti-1331	340	8	g.d	g.d	PROPN
dti-1331	340	9	.	.	PROPN
dti-1331	340	10	,	,	PUNCT
dti-1331	340	11	heien	heien	PROPN
dti-1331	340	12	,	,	PUNCT
dti-1331	340	13	m.l	m.l	PROPN
dti-1331	340	14	.	.	PROPN
dti-1331	340	15	,	,	PUNCT
dti-1331	340	16	wightman	wightman	PROPN
dti-1331	340	17	,	,	PUNCT
dti-1331	340	18	r.m	r.m	PROPN
dti-1331	340	19	.	.	PROPN
dti-1331	340	20	and	and	CCONJ
dti-1331	340	21	carelli	carelli	PROPN
dti-1331	340	22	,	,	PUNCT
dti-1331	340	23	r.m	r.m	PROPN
dti-1331	340	24	.	.	PROPN
dti-1331	340	25	2003	2003	NUM
dti-1331	340	26	.	.	PUNCT
dti-1331	341	1	subsecond	subsecond	ADJ
dti-1331	341	2	dopamine	dopamine	NOUN
dti-1331	341	3	release	release	NOUN
dti-1331	341	4	promotes	promote	VERB
dti-1331	341	5	cocaine	cocaine	NOUN
dti-1331	341	6	seeking	seeking	NOUN
dti-1331	341	7	.	.	PUNCT
dti-1331	342	1	nature	nature	NOUN
dti-1331	342	2	,	,	PUNCT
dti-1331	342	3	422:614–8	422:614–8	NOUN
dti-1331	342	4	.	.	PUNCT
dti-1331	343	1	pomara	pomara	NOUN
dti-1331	343	2	,	,	PUNCT
dti-1331	343	3	n.	n.	NOUN
dti-1331	343	4	,	,	PUNCT
dti-1331	343	5	peskind	peskind	NOUN
dti-1331	343	6	,	,	PUNCT
dti-1331	343	7	e.r	e.r	PROPN
dti-1331	343	8	.	.	PROPN
dti-1331	343	9	,	,	PUNCT
dti-1331	343	10	potkin	potkin	PROPN
dti-1331	343	11	,	,	PUNCT
dti-1331	343	12	s.g	s.g	PROPN
dti-1331	343	13	.	.	PROPN
dti-1331	343	14	et	et	PROPN
dti-1331	343	15	al	al	PROPN
dti-1331	343	16	.	.	PROPN
dti-1331	343	17	2004	2004	NUM
dti-1331	343	18	.	.	PUNCT
dti-1331	344	1	memantine	memantine	NOUN
dti-1331	344	2	monotherapy	monotherapy	NOUN
dti-1331	344	3	is	be	AUX
dti-1331	344	4	effective	effective	ADJ
dti-1331	344	5	and	and	CCONJ
dti-1331	344	6	safe	safe	ADJ
dti-1331	344	7	for	for	ADP
dti-1331	344	8	the	the	DET
dti-1331	344	9	treatment	treatment	NOUN
dti-1331	344	10	of	of	ADP
dti-1331	344	11	mild	mild	ADJ
dti-1331	344	12	to	to	ADP
dti-1331	344	13	moderate	moderate	ADJ
dti-1331	344	14	alzheimer	alzheimer	PROPN
dti-1331	344	15	’s	’s	PART
dti-1331	344	16	disease	disease	NOUN
dti-1331	344	17	:	:	PUNCT
dti-1331	344	18	a	a	DET
dti-1331	344	19	randomized	randomized	ADJ
dti-1331	344	20	controlled	control	VERB
dti-1331	344	21	trial	trial	NOUN
dti-1331	344	22	.	.	PUNCT
dti-1331	345	1	neurobiol	neurobiol	NOUN
dti-1331	345	2	.	.	PUNCT
dti-1331	346	1	aging	aging	NOUN
dti-1331	346	2	,	,	PUNCT
dti-1331	346	3	25:1	25:1	NUM
dti-1331	346	4	.	.	PUNCT
dti-1331	346	5	przedborski	przedborski	PROPN
dti-1331	346	6	,	,	PUNCT
dti-1331	346	7	s.	s.	PROPN
dti-1331	346	8	and	and	CCONJ
dti-1331	346	9	vila	vila	PROPN
dti-1331	346	10	,	,	PUNCT
dti-1331	346	11	m.	m.	NOUN
dti-1331	346	12	2003	2003	NUM
dti-1331	346	13	.	.	PUNCT
dti-1331	347	1	the	the	DET
dti-1331	347	2	1	1	NUM
dti-1331	347	3	-	-	PUNCT
dti-1331	347	4	methyl-4	methyl-4	NUM
dti-1331	347	5	-	-	PUNCT
dti-1331	347	6	phenyl1,2,3,6	phenyl1,2,3,6	ADJ
dti-1331	347	7	-	-	PUNCT
dti-1331	347	8	tetrahydropyridine	tetrahydropyridine	ADJ
dti-1331	347	9	mouse	mouse	NOUN
dti-1331	347	10	model	model	NOUN
dti-1331	347	11	:	:	PUNCT
dti-1331	347	12	a	a	DET
dti-1331	347	13	tool	tool	NOUN
dti-1331	347	14	to	to	PART
dti-1331	347	15	explore	explore	VERB
dti-1331	347	16	the	the	DET
dti-1331	347	17	pathogenesis	pathogenesis	NOUN
dti-1331	347	18	of	of	ADP
dti-1331	347	19	parkinson	parkinson	NOUN
dti-1331	347	20	’s	’s	PART
dti-1331	347	21	disease	disease	NOUN
dti-1331	347	22	.	.	PUNCT
dti-1331	348	1	ann	ann	PROPN
dti-1331	348	2	.	.	PUNCT
dti-1331	348	3	n.y	n.y	PROPN
dti-1331	348	4	.	.	PROPN
dti-1331	348	5	acad	acad	PROPN
dti-1331	348	6	.	.	PUNCT
dti-1331	349	1	sci	sci	PROPN
dti-1331	349	2	.	.	PROPN
dti-1331	349	3	,	,	PUNCT
dti-1331	349	4	991:189–98	991:189–98	NUM
dti-1331	349	5	.	.	PUNCT
dti-1331	350	1	rabey	rabey	PROPN
dti-1331	350	2	,	,	PUNCT
dti-1331	350	3	j.m	j.m	PROPN
dti-1331	350	4	.	.	PROPN
dti-1331	350	5	,	,	PUNCT
dti-1331	350	6	nissipeanu	nissipeanu	PROPN
dti-1331	350	7	,	,	PUNCT
dti-1331	350	8	p.	p.	NOUN
dti-1331	350	9	and	and	CCONJ
dti-1331	350	10	korczyn	korczyn	PROPN
dti-1331	350	11	,	,	PUNCT
dti-1331	350	12	a.	a.	NOUN
dti-1331	350	13	1992	1992	NUM
dti-1331	350	14	.	.	PUNCT
dti-1331	351	1	d	d	PROPN
dti-1331	351	2	effi	effi	PROPN
dti-1331	351	3	cacy	cacy	NOUN
dti-1331	351	4	of	of	ADP
dti-1331	351	5	memantine	memantine	NOUN
dti-1331	351	6	,	,	PUNCT
dti-1331	351	7	an	an	DET
dti-1331	351	8	nmda	nmda	ADJ
dti-1331	351	9	receptor	receptor	NOUN
dti-1331	351	10	antagonist	antagonist	NOUN
dti-1331	351	11	,	,	PUNCT
dti-1331	351	12	in	in	ADP
dti-1331	351	13	the	the	DET
dti-1331	351	14	treatment	treatment	NOUN
dti-1331	351	15	of	of	ADP
dti-1331	351	16	parkinson	parkinson	NOUN
dti-1331	351	17	’s	’s	PART
dti-1331	351	18	disease	disease	NOUN
dti-1331	351	19	.	.	PUNCT
dti-1331	352	1	journal	journal	PROPN
dti-1331	352	2	of	of	ADP
dti-1331	352	3	neural	neural	ADJ
dti-1331	352	4	transmission	transmission	NOUN
dti-1331	352	5	,	,	PUNCT
dti-1331	352	6	4(4):277–82	4(4):277–82	NOUN
dti-1331	352	7	.	.	PUNCT
dti-1331	352	8	rao	rao	PROPN
dti-1331	352	9	,	,	PUNCT
dti-1331	352	10	vlr	vlr	PROPN
dti-1331	352	11	.	.	PROPN
dti-1331	352	12	,	,	PUNCT
dti-1331	353	1	dogan	dogan	PROPN
dti-1331	353	2	,	,	PUNCT
dti-1331	353	3	a.	a.	PROPN
dti-1331	353	4	,	,	PUNCT
dti-1331	353	5	todd	todd	PROPN
dti-1331	353	6	,	,	PUNCT
dti-1331	353	7	k.g	k.g	PROPN
dti-1331	353	8	.	.	PROPN
dti-1331	353	9	et	et	PROPN
dti-1331	353	10	al	al	PROPN
dti-1331	353	11	.	.	PROPN
dti-1331	353	12	2001	2001	NUM
dti-1331	353	13	,	,	PUNCT
dti-1331	353	14	aug	aug	PROPN
dti-1331	353	15	17	17	NUM
dti-1331	353	16	.	.	PUNCT
dti-1331	353	17	neuroprotection	neuroprotection	NOUN
dti-1331	353	18	by	by	ADP
dti-1331	353	19	memantine	memantine	NOUN
dti-1331	353	20	,	,	PUNCT
dti-1331	353	21	a	a	DET
dti-1331	353	22	non	non	ADJ
dti-1331	353	23	-	-	ADJ
dti-1331	353	24	competitive	competitive	ADJ
dti-1331	353	25	nmda	nmda	ADJ
dti-1331	353	26	receptor	receptor	NOUN
dti-1331	353	27	antagonist	antagonist	NOUN
dti-1331	353	28	after	after	ADP
dti-1331	353	29	traumatic	traumatic	ADJ
dti-1331	353	30	brain	brain	NOUN
dti-1331	353	31	injury	injury	NOUN
dti-1331	353	32	in	in	ADP
dti-1331	353	33	rats	rat	NOUN
dti-1331	353	34	.	.	PUNCT
dti-1331	354	1	brain	brain	NOUN
dti-1331	354	2	res	re	NOUN
dti-1331	354	3	.	.	PROPN
dti-1331	354	4	,	,	PUNCT
dti-1331	355	1	911(1):96–100	911(1):96–100	PROPN
dti-1331	355	2	.	.	PUNCT
dti-1331	355	3	reisberg	reisberg	PROPN
dti-1331	355	4	,	,	PUNCT
dti-1331	355	5	b.	b.	PROPN
dti-1331	355	6	,	,	PUNCT
dti-1331	355	7	mobius	mobius	PROPN
dti-1331	355	8	,	,	PUNCT
dti-1331	355	9	h.j	h.j	PROPN
dti-1331	355	10	.	.	PROPN
dti-1331	355	11	,	,	PUNCT
dti-1331	355	12	stomer	stomer	PROPN
dti-1331	355	13	,	,	PUNCT
dti-1331	355	14	a.	a.	PROPN
dti-1331	355	15	et	et	PROPN
dti-1331	355	16	al	al	PROPN
dti-1331	355	17	.	.	PROPN
dti-1331	355	18	2000	2000	NUM
dti-1331	355	19	,	,	PUNCT
dti-1331	355	20	july	july	PROPN
dti-1331	355	21	20–25	20–25	NUM
dti-1331	355	22	.	.	PUNCT
dti-1331	356	1	long	long	ADJ
dti-1331	356	2	-	-	PUNCT
dti-1331	356	3	term	term	NOUN
dti-1331	356	4	treatment	treatment	NOUN
dti-1331	356	5	with	with	ADP
dti-1331	356	6	the	the	DET
dti-1331	356	7	nmda	nmda	ADJ
dti-1331	356	8	antagonist	antagonist	NOUN
dti-1331	356	9	memantine	memantine	NOUN
dti-1331	356	10	;	;	PUNCT
dti-1331	356	11	results	result	NOUN
dti-1331	356	12	of	of	ADP
dti-1331	356	13	a	a	DET
dti-1331	356	14	24	24	NUM
dti-1331	356	15	-	-	PUNCT
dti-1331	356	16	week	week	NOUN
dti-1331	356	17	,	,	PUNCT
dti-1331	356	18	open	open	ADJ
dti-1331	356	19	-	-	PUNCT
dti-1331	356	20	label	label	NOUN
dti-1331	356	21	extension	extension	NOUN
dti-1331	356	22	study	study	NOUN
dti-1331	356	23	in	in	ADP
dti-1331	356	24	moderately	moderately	ADV
dti-1331	356	25	severe	severe	ADJ
dti-1331	356	26	to	to	ADP
dti-1331	356	27	severe	severe	ADJ
dti-1331	356	28	alzheimer	alzheimer	PROPN
dti-1331	356	29	’s	’s	PART
dti-1331	356	30	disease	disease	NOUN
dti-1331	357	1	[	[	X
dti-1331	357	2	abstract	abstract	X
dti-1331	357	3	]	]	X
dti-1331	357	4	.	.	PUNCT
dti-1331	358	1	8th	8th	ADJ
dti-1331	358	2	international	international	ADJ
dti-1331	358	3	conference	conference	NOUN
dti-1331	358	4	on	on	ADP
dti-1331	358	5	alzheimer	alzheimer	PROPN
dti-1331	358	6	’s	’s	PART
dti-1331	358	7	disease	disease	NOUN
dti-1331	358	8	and	and	CCONJ
dti-1331	358	9	related	related	ADJ
dti-1331	358	10	disorders	disorder	NOUN
dti-1331	358	11	,	,	PUNCT
dti-1331	358	12	stockholm	stockholm	PROPN
dti-1331	358	13	.	.	PUNCT
dti-1331	359	1	reisberg	reisberg	PROPN
dti-1331	359	2	,	,	PUNCT
dti-1331	359	3	b.	b.	PROPN
dti-1331	359	4	,	,	PUNCT
dti-1331	359	5	doody	doody	PROPN
dti-1331	359	6	,	,	PUNCT
dti-1331	359	7	r.	r.	PROPN
dti-1331	359	8	,	,	PUNCT
dti-1331	359	9	stamer	stamer	NOUN
dti-1331	359	10	,	,	PUNCT
dti-1331	359	11	a.	a.	PROPN
dti-1331	359	12	et	et	PROPN
dti-1331	359	13	al	al	PROPN
dti-1331	359	14	.	.	PROPN
dti-1331	359	15	2003	2003	NUM
dti-1331	359	16	.	.	PUNCT
dti-1331	360	1	a	a	DET
dti-1331	360	2	randomized	randomized	ADJ
dti-1331	360	3	,	,	PUNCT
dti-1331	360	4	placebo	placebo	NOUN
dti-1331	360	5	controlled	control	VERB
dti-1331	360	6	study	study	NOUN
dti-1331	360	7	of	of	ADP
dti-1331	360	8	memantine	memantine	NOUN
dti-1331	360	9	,	,	PUNCT
dti-1331	360	10	an	an	DET
dti-1331	360	11	uncompetitive	uncompetitive	ADJ
dti-1331	360	12	nmda	nmda	ADJ
dti-1331	360	13	antagonist	antagonist	NOUN
dti-1331	360	14	,	,	PUNCT
dti-1331	360	15	in	in	ADP
dti-1331	360	16	patients	patient	NOUN
dti-1331	360	17	with	with	ADP
dti-1331	360	18	moderate	moderate	ADJ
dti-1331	360	19	to	to	ADP
dti-1331	360	20	severe	severe	PROPN
dti-1331	360	21	alzheimer	alzheimer	PROPN
dti-1331	360	22	’s	’s	PART
dti-1331	360	23	disease	disease	NOUN
dti-1331	360	24	.	.	PUNCT
dti-1331	361	1	n.	n.	PROPN
dti-1331	361	2	engl	engl	PROPN
dti-1331	361	3	.	.	PUNCT
dti-1331	362	1	j.	j.	PROPN
dti-1331	362	2	med	med	PROPN
dti-1331	362	3	.	.	PROPN
dti-1331	362	4	,	,	PUNCT
dti-1331	363	1	348:1333–41	348:1333–41	X
dti-1331	363	2	.	.	PUNCT
dti-1331	364	1	rothman	rothman	PROPN
dti-1331	364	2	,	,	PUNCT
dti-1331	364	3	s.m	s.m	PROPN
dti-1331	364	4	.	.	PROPN
dti-1331	364	5	and	and	CCONJ
dti-1331	364	6	olney	olney	PROPN
dti-1331	364	7	,	,	PUNCT
dti-1331	364	8	j.w	j.w	PROPN
dti-1331	364	9	.	.	PROPN
dti-1331	364	10	1987	1987	NUM
dti-1331	364	11	.	.	PUNCT
dti-1331	365	1	excitotoxicity	excitotoxicity	NOUN
dti-1331	365	2	and	and	CCONJ
dti-1331	365	3	the	the	DET
dti-1331	365	4	nmda	nmda	ADJ
dti-1331	365	5	receptor	receptor	NOUN
dti-1331	365	6	.	.	PUNCT
dti-1331	366	1	trends	trend	NOUN
dti-1331	366	2	neurosci	neurosci	PROPN
dti-1331	366	3	.	.	PUNCT
dti-1331	366	4	,	,	PUNCT
dti-1331	366	5	10:299–302	10:299–302	PROPN
dti-1331	366	6	.	.	PUNCT
dti-1331	366	7	salthun	salthun	NOUN
dti-1331	366	8	-	-	PUNCT
dti-1331	366	9	lassalle	lassalle	PROPN
dti-1331	366	10	,	,	PUNCT
dti-1331	366	11	b.	b.	PROPN
dti-1331	366	12	,	,	PUNCT
dti-1331	366	13	hirsch	hirsch	PROPN
dti-1331	366	14	,	,	PUNCT
dti-1331	366	15	e.c	e.c	PROPN
dti-1331	366	16	.	.	PROPN
dti-1331	366	17	,	,	PUNCT
dti-1331	366	18	wolfart	wolfart	PROPN
dti-1331	366	19	,	,	PUNCT
dti-1331	366	20	j.	j.	PROPN
dti-1331	366	21	,	,	PUNCT
dti-1331	366	22	ruberg	ruberg	PROPN
dti-1331	366	23	,	,	PUNCT
dti-1331	366	24	m.	m.	NOUN
dti-1331	366	25	and	and	CCONJ
dti-1331	366	26	michel	michel	PROPN
dti-1331	366	27	,	,	PUNCT
dti-1331	366	28	p.p	p.p	PROPN
dti-1331	366	29	.	.	PROPN
dti-1331	366	30	2004	2004	NUM
dti-1331	366	31	.	.	PUNCT
dti-1331	367	1	rescue	rescue	NOUN
dti-1331	367	2	of	of	ADP
dti-1331	367	3	mesencephalic	mesencephalic	ADJ
dti-1331	367	4	dopaminergic	dopaminergic	ADJ
dti-1331	367	5	neurons	neuron	NOUN
dti-1331	367	6	in	in	ADP
dti-1331	367	7	culture	culture	NOUN
dti-1331	367	8	by	by	ADP
dti-1331	367	9	low	low	ADJ
dti-1331	367	10	-	-	PUNCT
dti-1331	367	11	level	level	NOUN
dti-1331	367	12	stimulation	stimulation	NOUN
dti-1331	367	13	of	of	ADP
dti-1331	367	14	voltage	voltage	NOUN
dti-1331	367	15	-	-	PUNCT
dti-1331	367	16	gated	gate	VERB
dti-1331	367	17	sodium	sodium	NOUN
dti-1331	367	18	channels	channel	NOUN
dti-1331	367	19	.	.	PUNCT
dti-1331	368	1	j.	j.	PROPN
dti-1331	368	2	neurosi	neurosi	PROPN
dti-1331	368	3	,	,	PUNCT
dti-1331	368	4	24:5922–30	24:5922–30	NUM
dti-1331	368	5	.	.	PUNCT
dti-1331	368	6	schmitt	schmitt	PROPN
dti-1331	368	7	,	,	PUNCT
dti-1331	368	8	f.	f.	PROPN
dti-1331	368	9	,	,	PUNCT
dti-1331	368	10	van	van	PROPN
dti-1331	368	11	dyck	dyck	PROPN
dti-1331	368	12	,	,	PUNCT
dti-1331	368	13	c.	c.	PROPN
dti-1331	368	14	,	,	PUNCT
dti-1331	368	15	wichems	wichem	NOUN
dti-1331	368	16	,	,	PUNCT
dti-1331	368	17	c.	c.	PROPN
dti-1331	368	18	,	,	PUNCT
dti-1331	368	19	olin	olin	PROPN
dti-1331	368	20	,	,	PUNCT
dti-1331	368	21	j.	j.	PROPN
dti-1331	368	22	and	and	CCONJ
dti-1331	368	23	for	for	ADP
dti-1331	368	24	the	the	DET
dti-1331	368	25	mem	mem	ADJ
dti-1331	368	26	md	md	PROPN
dti-1331	368	27	02	02	NUM
dti-1331	368	28	study	study	NOUN
dti-1331	368	29	group	group	NOUN
dti-1331	368	30	,	,	PUNCT
dti-1331	368	31	2006	2006	NUM
dti-1331	368	32	.	.	PUNCT
dti-1331	369	1	cognitive	cognitive	ADJ
dti-1331	369	2	response	response	NOUN
dti-1331	369	3	to	to	PART
dti-1331	369	4	memantine	memantine	VERB
dti-1331	369	5	in	in	ADP
dti-1331	369	6	moderate	moderate	ADJ
dti-1331	369	7	to	to	ADP
dti-1331	369	8	severe	severe	ADJ
dti-1331	369	9	alzheimer	alzheimer	PROPN
dti-1331	369	10	disease	disease	NOUN
dti-1331	369	11	patients	patient	NOUN
dti-1331	369	12	already	already	ADV
dti-1331	369	13	receiving	receive	VERB
dti-1331	369	14	donepezil	donepezil	NOUN
dti-1331	369	15	:	:	PUNCT
dti-1331	369	16	an	an	DET
dti-1331	369	17	exploratory	exploratory	ADJ
dti-1331	369	18	reanalysis	reanalysis	NOUN
dti-1331	369	19	.	.	PUNCT
dti-1331	370	1	alzh	alzh	NOUN
dti-1331	370	2	.	.	PUNCT
dti-1331	371	1	dis	dis	PROPN
dti-1331	371	2	.	.	PUNCT
dti-1331	372	1	ass	ass	PROPN
dti-1331	372	2	.	.	PUNCT
dti-1331	373	1	dis	dis	PROPN
dti-1331	373	2	.	.	PROPN
dti-1331	373	3	,	,	PUNCT
dti-1331	373	4	20(4):255–62	20(4):255–62	NUM
dti-1331	373	5	.	.	PUNCT
dti-1331	373	6	seeman	seeman	PROPN
dti-1331	373	7	,	,	PUNCT
dti-1331	373	8	p.	p.	PROPN
dti-1331	373	9	,	,	PUNCT
dti-1331	373	10	caruso	caruso	PROPN
dti-1331	373	11	,	,	PUNCT
dti-1331	373	12	c.	c.	PROPN
dti-1331	373	13	and	and	CCONJ
dti-1331	373	14	lasaga	lasaga	NOUN
dti-1331	373	15	,	,	PUNCT
dti-1331	373	16	m.	m.	NOUN
dti-1331	373	17	2007	2007	NUM
dti-1331	373	18	,	,	PUNCT
dti-1331	373	19	nov	nov	PROPN
dti-1331	373	20	13	13	NUM
dti-1331	373	21	.	.	PUNCT
dti-1331	373	22	memantine	memantine	ADJ
dti-1331	373	23	agonist	agonist	NOUN
dti-1331	373	24	action	action	NOUN
dti-1331	373	25	at	at	ADP
dti-1331	373	26	dopamine	dopamine	NOUN
dti-1331	373	27	d2(high	d2(high	ADJ
dti-1331	373	28	)	)	PUNCT
dti-1331	373	29	receptors	receptor	NOUN
dti-1331	373	30	.	.	PUNCT
dti-1331	374	1	synapse	synapse	NOUN
dti-1331	374	2	,	,	PUNCT
dti-1331	374	3	62(2):149–53	62(2):149–53	NUM
dti-1331	374	4	.	.	PUNCT
dti-1331	375	1	seif	seif	PROPN
dti-1331	375	2	ej	ej	PROPN
dti-1331	375	3	.	.	PROPN
dti-1331	375	4	nasi	nasi	PROPN
dti-1331	375	5	’	'	PUNCT
dti-1331	375	6	,	,	PUNCT
dti-1331	375	7	m.	m.	NOUN
dti-1331	375	8	,	,	PUNCT
dti-1331	375	9	peruche	peruche	PROPN
dti-1331	375	10	,	,	PUNCT
dti-1331	375	11	b.	b.	PROPN
dti-1331	375	12	,	,	PUNCT
dti-1331	375	13	rossberg	rossberg	PROPN
dti-1331	375	14	,	,	PUNCT
dti-1331	375	15	c.	c.	PROPN
dti-1331	375	16	et	et	PROPN
dti-1331	375	17	al	al	PROPN
dti-1331	375	18	.	.	PROPN
dti-1331	375	19	1990	1990	NUM
dti-1331	375	20	,	,	PUNCT
dti-1331	375	21	aug	aug	PROPN
dti-1331	375	22	21	21	NUM
dti-1331	375	23	.	.	PUNCT
dti-1331	376	1	neuroprotective	neuroprotective	ADJ
dti-1331	376	2	effect	effect	NOUN
dti-1331	376	3	of	of	ADP
dti-1331	376	4	memantine	memantine	NOUN
dti-1331	376	5	demonstrated	demonstrate	VERB
dti-1331	376	6	in	in	ADP
dti-1331	376	7	vivo	vivo	NOUN
dti-1331	376	8	and	and	CCONJ
dti-1331	376	9	in	in	ADP
dti-1331	376	10	vitro	vitro	X
dti-1331	376	11	.	.	PUNCT
dti-1331	377	1	eur	eur	PROPN
dti-1331	377	2	.	.	PUNCT
dti-1331	378	1	j.	j.	PROPN
dti-1331	378	2	pharmacol	pharmacol	PROPN
dti-1331	378	3	.	.	PROPN
dti-1331	378	4	,	,	PUNCT
dti-1331	378	5	j.	j.	PROPN
dti-1331	378	6	85(1):19–24	85(1):19–24	PROPN
dti-1331	378	7	.	.	PUNCT
dti-1331	379	1	stieg	stieg	PROPN
dti-1331	379	2	,	,	PUNCT
dti-1331	379	3	p.e	p.e	PROPN
dti-1331	379	4	.	.	PROPN
dti-1331	379	5	,	,	PUNCT
dti-1331	379	6	sathi	sathi	PROPN
dti-1331	379	7	,	,	PUNCT
dti-1331	379	8	s.	s.	PROPN
dti-1331	379	9	,	,	PUNCT
dti-1331	379	10	warach	warach	NOUN
dti-1331	379	11	,	,	PUNCT
dti-1331	379	12	s.	s.	PROPN
dti-1331	379	13	et	et	PROPN
dti-1331	379	14	al	al	PROPN
dti-1331	379	15	.	.	PROPN
dti-1331	379	16	1999	1999	NUM
dti-1331	379	17	,	,	PUNCT
dti-1331	379	18	jun	jun	PROPN
dti-1331	379	19	30	30	NUM
dti-1331	379	20	.	.	PUNCT
dti-1331	379	21	neuroprotection	neuroprotection	NOUN
dti-1331	379	22	by	by	ADP
dti-1331	379	23	the	the	DET
dti-1331	379	24	nmda	nmda	ADJ
dti-1331	379	25	receptor	receptor	NOUN
dti-1331	379	26	-	-	PUNCT
dti-1331	379	27	associated	associate	VERB
dti-1331	379	28	open	open	ADJ
dti-1331	379	29	-	-	PUNCT
dti-1331	379	30	channel	channel	NOUN
dti-1331	379	31	blocker	blocker	NOUN
dti-1331	379	32	memantine	memantine	NOUN
dti-1331	379	33	in	in	ADP
dti-1331	379	34	a	a	DET
dti-1331	379	35	photothrombotic	photothrombotic	ADJ
dti-1331	379	36	model	model	NOUN
dti-1331	379	37	of	of	ADP
dti-1331	379	38	cerebral	cerebral	ADJ
dti-1331	379	39	focal	focal	ADJ
dti-1331	379	40	ischemia	ischemia	NOUN
dti-1331	379	41	in	in	ADP
dti-1331	379	42	neonatal	neonatal	ADJ
dti-1331	379	43	rat	rat	NOUN
dti-1331	379	44	.	.	PUNCT
dti-1331	379	45	eur	eur	PROPN
dti-1331	379	46	.	.	PUNCT
dti-1331	380	1	j.	j.	PROPN
dti-1331	380	2	pharmacol	pharmacol	PROPN
dti-1331	380	3	.	.	PROPN
dti-1331	380	4	,	,	PUNCT
dti-1331	380	5	375(1–3):115–20	375(1–3):115–20	NUM
dti-1331	380	6	.	.	PUNCT
dti-1331	380	7	85	85	NUM
dti-1331	380	8	memantine	memantine	NOUN
dti-1331	380	9	:	:	PUNCT
dti-1331	380	10	reality	reality	NOUN
dti-1331	380	11	and	and	CCONJ
dti-1331	380	12	potentiality	potentiality	NOUN
dti-1331	380	13	drug	drug	NOUN
dti-1331	380	14	target	target	NOUN
dti-1331	380	15	insights	insight	NOUN
dti-1331	380	16	2008:3	2008:3	NUM
dti-1331	380	17	sudhir	sudhir	PROPN
dti-1331	380	18	,	,	PUNCT
dti-1331	380	19	k.	k.	PROPN
dti-1331	380	20	2004	2004	NUM
dti-1331	380	21	.	.	PUNCT
dti-1331	381	1	memantine	memantine	NOUN
dti-1331	381	2	:	:	PUNCT
dti-1331	381	3	pharmacological	pharmacological	ADJ
dti-1331	381	4	properties	property	NOUN
dti-1331	381	5	and	and	CCONJ
dti-1331	381	6	clinical	clinical	ADJ
dti-1331	381	7	uses	use	NOUN
dti-1331	381	8	.	.	PUNCT
dti-1331	382	1	neurology	neurology	PROPN
dti-1331	382	2	india	india	PROPN
dti-1331	382	3	,	,	PUNCT
dti-1331	382	4	52(3):307–9	52(3):307–9	NUM
dti-1331	382	5	.	.	PUNCT
dti-1331	383	1	tariot	tariot	PROPN
dti-1331	383	2	,	,	PUNCT
dti-1331	383	3	p.	p.	NOUN
dti-1331	383	4	,	,	PUNCT
dti-1331	383	5	farlow	farlow	ADJ
dti-1331	383	6	,	,	PUNCT
dti-1331	383	7	m.	m.	NOUN
dti-1331	383	8	,	,	PUNCT
dti-1331	383	9	grossberg	grossberg	PROPN
dti-1331	383	10	,	,	PUNCT
dti-1331	383	11	g.	g.	PROPN
dti-1331	383	12	et	et	PROPN
dti-1331	383	13	al	al	PROPN
dti-1331	383	14	.	.	PROPN
dti-1331	383	15	2003	2003	NUM
dti-1331	383	16	,	,	PUNCT
dti-1331	383	17	may	may	AUX
dti-1331	383	18	.	.	PUNCT
dti-1331	383	19	memantine	memantine	PROPN
dti-1331	383	20	/	/	SYM
dti-1331	383	21	donepezil	donepezil	PROPN
dti-1331	383	22	dual	dual	ADJ
dti-1331	383	23	therapy	therapy	NOUN
dti-1331	383	24	is	be	AUX
dti-1331	383	25	superior	superior	ADJ
dti-1331	383	26	to	to	ADP
dti-1331	383	27	placebo	placebo	NOUN
dti-1331	383	28	/	/	SYM
dti-1331	383	29	donepezil	donepezil	NOUN
dti-1331	383	30	therapy	therapy	NOUN
dti-1331	383	31	for	for	ADP
dti-1331	383	32	treatment	treatment	NOUN
dti-1331	383	33	of	of	ADP
dti-1331	383	34	moderate	moderate	ADJ
dti-1331	383	35	to	to	ADP
dti-1331	383	36	severe	severe	ADJ
dti-1331	383	37	alzheimer	alzheimer	PROPN
dti-1331	383	38	’s	’s	PART
dti-1331	383	39	disease	disease	NOUN
dti-1331	383	40	.	.	PUNCT
dti-1331	384	1	poster	poster	NOUN
dti-1331	384	2	presented	present	VERB
dti-1331	384	3	at	at	ADP
dti-1331	384	4	the	the	DET
dti-1331	384	5	american	american	PROPN
dti-1331	384	6	psychiatric	psychiatric	PROPN
dti-1331	384	7	association	association	PROPN
dti-1331	384	8	annual	annual	ADJ
dti-1331	384	9	meeting	meeting	NOUN
dti-1331	384	10	,	,	PUNCT
dti-1331	384	11	san	san	PROPN
dti-1331	384	12	francisco	francisco	PROPN
dti-1331	384	13	,	,	PUNCT
dti-1331	384	14	u.s.a	u.s.a	PROPN
dti-1331	384	15	.	.	PROPN
dti-1331	384	16	tariot	tariot	PROPN
dti-1331	384	17	,	,	PUNCT
dti-1331	384	18	p.n	p.n	PROPN
dti-1331	384	19	.	.	PROPN
dti-1331	384	20	,	,	PUNCT
dti-1331	384	21	farlow	farlow	ADJ
dti-1331	384	22	,	,	PUNCT
dti-1331	384	23	m.r	m.r	PROPN
dti-1331	384	24	.	.	PROPN
dti-1331	384	25	,	,	PUNCT
dti-1331	384	26	grossberg	grossberg	PROPN
dti-1331	384	27	,	,	PUNCT
dti-1331	384	28	g.t	g.t	PROPN
dti-1331	384	29	.	.	PROPN
dti-1331	384	30	,	,	PUNCT
dti-1331	384	31	graham	graham	PROPN
dti-1331	384	32	,	,	PUNCT
dti-1331	384	33	s.m	s.m	PROPN
dti-1331	384	34	.	.	PROPN
dti-1331	384	35	,	,	PUNCT
dti-1331	384	36	mcdonald	mcdonald	PROPN
dti-1331	384	37	,	,	PUNCT
dti-1331	384	38	s.	s.	PROPN
dti-1331	384	39	and	and	CCONJ
dti-1331	384	40	gergel	gergel	NOUN
dti-1331	384	41	,	,	PUNCT
dti-1331	384	42	i.	i.	PROPN
dti-1331	384	43	2004	2004	NUM
dti-1331	384	44	.	.	PUNCT
dti-1331	385	1	memantine	memantine	ADJ
dti-1331	385	2	treatment	treatment	NOUN
dti-1331	385	3	in	in	ADP
dti-1331	385	4	patients	patient	NOUN
dti-1331	385	5	with	with	ADP
dti-1331	385	6	moderate	moderate	ADJ
dti-1331	385	7	to	to	ADP
dti-1331	385	8	severe	severe	ADJ
dti-1331	385	9	alzheimer	alzheimer	NOUN
dti-1331	385	10	disease	disease	NOUN
dti-1331	385	11	already	already	ADV
dti-1331	385	12	receiving	receive	VERB
dti-1331	385	13	donepezil	donepezil	NOUN
dti-1331	385	14	:	:	PUNCT
dti-1331	385	15	a	a	DET
dti-1331	385	16	randomized	randomized	ADJ
dti-1331	385	17	controlled	control	VERB
dti-1331	385	18	trial	trial	NOUN
dti-1331	385	19	.	.	PUNCT
dti-1331	386	1	jama	jama	PROPN
dti-1331	386	2	,	,	PUNCT
dti-1331	386	3	291:317–24	291:317–24	PROPN
dti-1331	386	4	.	.	PUNCT
dti-1331	387	1	weller	weller	PROPN
dti-1331	387	2	,	,	PUNCT
dti-1331	387	3	m.	m.	NOUN
dti-1331	387	4	,	,	PUNCT
dti-1331	387	5	finiels	finiel	NOUN
dti-1331	387	6	-	-	PUNCT
dti-1331	387	7	marlier	marlier	NOUN
dti-1331	387	8	,	,	PUNCT
dti-1331	387	9	f.	f.	PROPN
dti-1331	387	10	and	and	CCONJ
dti-1331	387	11	paul	paul	PROPN
dti-1331	387	12	,	,	PUNCT
dti-1331	387	13	s.m	s.m	PROPN
dti-1331	387	14	.	.	PROPN
dti-1331	387	15	1993	1993	NUM
dti-1331	387	16	.	.	PUNCT
dti-1331	388	1	nmda	nmda	ADJ
dti-1331	388	2	receptormediated	receptormediate	VERB
dti-1331	388	3	glutamate	glutamate	NOUN
dti-1331	388	4	toxicity	toxicity	NOUN
dti-1331	388	5	of	of	ADP
dti-1331	388	6	cultured	cultured	ADJ
dti-1331	388	7	cerebellar	cerebellar	ADJ
dti-1331	388	8	,	,	PUNCT
dti-1331	388	9	cortical	cortical	ADJ
dti-1331	388	10	and	and	CCONJ
dti-1331	388	11	mesencephalic	mesencephalic	ADJ
dti-1331	388	12	neurons	neuron	NOUN
dti-1331	388	13	:	:	PUNCT
dti-1331	388	14	neuroprotective	neuroprotective	ADJ
dti-1331	388	15	properties	property	NOUN
dti-1331	388	16	of	of	ADP
dti-1331	388	17	amantadine	amantadine	NOUN
dti-1331	388	18	and	and	CCONJ
dti-1331	388	19	memantine	memantine	NOUN
dti-1331	388	20	.	.	PUNCT
dti-1331	389	1	brain	brain	NOUN
dti-1331	389	2	res	re	NOUN
dti-1331	389	3	.	.	PUNCT
dti-1331	389	4	,	,	PUNCT
dti-1331	390	1	613:143–8	613:143–8	NUM
dti-1331	390	2	.	.	PUNCT
dti-1331	391	1	wenk	wenk	PROPN
dti-1331	391	2	,	,	PUNCT
dti-1331	391	3	g.l	g.l	PROPN
dti-1331	391	4	.	.	PROPN
dti-1331	391	5	,	,	PUNCT
dti-1331	391	6	zajaczkowski	zajaczkowski	PROPN
dti-1331	391	7	,	,	PUNCT
dti-1331	391	8	w.	w.	NOUN
dti-1331	391	9	and	and	CCONJ
dti-1331	391	10	danysz	danysz	PROPN
dti-1331	391	11	,	,	PUNCT
dti-1331	391	12	w.	w.	PROPN
dti-1331	391	13	1997	1997	NUM
dti-1331	391	14	,	,	PUNCT
dti-1331	391	15	feb	feb	PROPN
dti-1331	391	16	.	.	PROPN
dti-1331	391	17	neuroprotection	neuroprotection	NOUN
dti-1331	391	18	of	of	ADP
dti-1331	391	19	acetylcholinergic	acetylcholinergic	ADJ
dti-1331	391	20	basal	basal	NOUN
dti-1331	391	21	forebrain	forebrain	NOUN
dti-1331	391	22	neurons	neuron	NOUN
dti-1331	391	23	by	by	ADP
dti-1331	391	24	memantine	memantine	NOUN
dti-1331	391	25	and	and	CCONJ
dti-1331	391	26	neurokinin	neurokinin	PROPN
dti-1331	391	27	b.	b.	PROPN
dti-1331	391	28	behav	behav	PROPN
dti-1331	391	29	.	.	PUNCT
dti-1331	392	1	brain	brain	NOUN
dti-1331	392	2	res	re	NOUN
dti-1331	392	3	.	.	PUNCT
dti-1331	392	4	,	,	PUNCT
dti-1331	392	5	83	83	NUM
dti-1331	392	6	(	(	PUNCT
dti-1331	392	7	1–2):129–33	1–2):129–33	PROPN
dti-1331	392	8	.	.	PUNCT
dti-1331	393	1	wilcock	wilcock	PROPN
dti-1331	393	2	,	,	PUNCT
dti-1331	393	3	g.	g.	PROPN
dti-1331	393	4	,	,	PUNCT
dti-1331	393	5	mobius	mobius	PROPN
dti-1331	393	6	,	,	PUNCT
dti-1331	393	7	h.j	h.j	PROPN
dti-1331	393	8	.	.	PROPN
dti-1331	393	9	and	and	CCONJ
dti-1331	393	10	stoffler	stoffler	NOUN
dti-1331	393	11	,	,	PUNCT
dti-1331	393	12	a.	a.	NOUN
dti-1331	393	13	2002	2002	NUM
dti-1331	393	14	.	.	PUNCT
dti-1331	394	1	on	on	ADP
dti-1331	394	2	behalf	behalf	NOUN
dti-1331	394	3	of	of	ADP
dti-1331	394	4	the	the	DET
dti-1331	394	5	mmm	mmm	PROPN
dti-1331	394	6	500	500	NUM
dti-1331	394	7	group	group	NOUN
dti-1331	394	8	a	a	DET
dti-1331	394	9	double	double	ADJ
dti-1331	394	10	-	-	PUNCT
dti-1331	394	11	blind	blind	ADJ
dti-1331	394	12	,	,	PUNCT
dti-1331	394	13	placebo	placebo	NOUN
dti-1331	394	14	-	-	PUNCT
dti-1331	394	15	controlled	control	VERB
dti-1331	394	16	multi	multi	ADJ
dti-1331	394	17	centre	centre	NOUN
dti-1331	394	18	study	study	NOUN
dti-1331	394	19	of	of	ADP
dti-1331	394	20	memantine	memantine	NOUN
dti-1331	394	21	in	in	ADP
dti-1331	394	22	mild	mild	ADJ
dti-1331	394	23	to	to	ADP
dti-1331	394	24	moderate	moderate	ADJ
dti-1331	394	25	vascular	vascular	ADJ
dti-1331	394	26	dementia	dementia	NOUN
dti-1331	394	27	(	(	PUNCT
dti-1331	394	28	mmm500	mmm500	PROPN
dti-1331	394	29	)	)	PUNCT
dti-1331	394	30	.	.	PUNCT
dti-1331	395	1	international	international	ADJ
dti-1331	395	2	clinical	clinical	ADJ
dti-1331	395	3	psychopharmacology	psychopharmacology	NOUN
dti-1331	395	4	,	,	PUNCT
dti-1331	395	5	17:297–305	17:297–305	NUM
dti-1331	395	6	.	.	PUNCT
dti-1331	396	1	winblad	winblad	PROPN
dti-1331	396	2	,	,	PUNCT
dti-1331	396	3	b.	b.	PROPN
dti-1331	396	4	,	,	PUNCT
dti-1331	396	5	mobius	mobius	PROPN
dti-1331	396	6	,	,	PUNCT
dti-1331	396	7	h.j	h.j	PROPN
dti-1331	396	8	.	.	PROPN
dti-1331	396	9	and	and	CCONJ
dti-1331	396	10	stoffl	stoffl	PROPN
dti-1331	396	11	er	er	INTJ
dti-1331	396	12	,	,	PUNCT
dti-1331	396	13	a.	a.	NOUN
dti-1331	396	14	2002	2002	NUM
dti-1331	396	15	.	.	PUNCT
dti-1331	397	1	glutamate	glutamate	ADJ
dti-1331	397	2	receptors	receptor	NOUN
dti-1331	397	3	as	as	ADP
dti-1331	397	4	a	a	DET
dti-1331	397	5	target	target	NOUN
dti-1331	397	6	for	for	ADP
dti-1331	397	7	alzheimer	alzheimer	PROPN
dti-1331	397	8	’s	’s	PART
dti-1331	397	9	disease	disease	NOUN
dti-1331	397	10	—	—	PUNCT
dti-1331	397	11	are	be	AUX
dti-1331	397	12	clinical	clinical	ADJ
dti-1331	397	13	results	result	NOUN
dti-1331	397	14	supporting	support	VERB
dti-1331	397	15	the	the	DET
dti-1331	397	16	hope	hope	NOUN
dti-1331	397	17	?	?	PUNCT
dti-1331	398	1	j.	j.	PROPN
dti-1331	398	2	neural	neural	PROPN
dti-1331	398	3	.	.	PUNCT
dti-1331	399	1	transm	transm	PROPN
dti-1331	399	2	.	.	PROPN
dti-1331	399	3	,	,	PUNCT
dti-1331	399	4	62(suppl):217–25	62(suppl):217–25	PROPN
dti-1331	399	5	.	.	PUNCT
dti-1331	399	6	winblad	winblad	PROPN
dti-1331	399	7	,	,	PUNCT
dti-1331	399	8	b.	b.	PROPN
dti-1331	399	9	,	,	PUNCT
dti-1331	399	10	jones	jones	PROPN
dti-1331	399	11	,	,	PUNCT
dti-1331	399	12	r.w	r.w	PROPN
dti-1331	399	13	.	.	PROPN
dti-1331	399	14	,	,	PUNCT
dti-1331	399	15	wirth	wirth	PROPN
dti-1331	399	16	,	,	PUNCT
dti-1331	399	17	y.	y.	PROPN
dti-1331	399	18	et	et	PROPN
dti-1331	399	19	al	al	PROPN
dti-1331	399	20	.	.	PROPN
dti-1331	399	21	2006	2006	NUM
dti-1331	399	22	,	,	PUNCT
dti-1331	399	23	september	september	PROPN
dti-1331	399	24	.	.	PUNCT
dti-1331	400	1	meta	meta	ADJ
dti-1331	400	2	-	-	PUNCT
dti-1331	400	3	analysis	analysis	NOUN
dti-1331	400	4	of	of	ADP
dti-1331	400	5	clinical	clinical	ADJ
dti-1331	400	6	trial	trial	NOUN
dti-1331	400	7	data	datum	NOUN
dti-1331	400	8	with	with	ADP
dti-1331	400	9	memantine	memantine	NOUN
dti-1331	400	10	in	in	ADP
dti-1331	400	11	moderate	moderate	ADJ
dti-1331	400	12	to	to	ADP
dti-1331	400	13	severe	severe	ADJ
dti-1331	400	14	alzheimer	alzheimer	PROPN
dti-1331	400	15	’s	’s	PART
dti-1331	400	16	disease	disease	NOUN
dti-1331	400	17	.	.	PUNCT
dti-1331	401	1	poster	poster	NOUN
dti-1331	401	2	presented	present	VERB
dti-1331	401	3	at	at	ADP
dti-1331	401	4	efns	efns	NOUN
dti-1331	401	5	.	.	PUNCT
dti-1331	402	1	wu	wu	PROPN
dti-1331	402	2	,	,	PUNCT
dti-1331	402	3	j.q	j.q	PROPN
dti-1331	402	4	.	.	PROPN
dti-1331	402	5	,	,	PUNCT
dti-1331	402	6	anwyl	anwyl	PROPN
dti-1331	402	7	,	,	PUNCT
dti-1331	402	8	r.	r.	PROPN
dti-1331	402	9	and	and	CCONJ
dti-1331	402	10	rowan	rowan	PROPN
dti-1331	402	11	,	,	PUNCT
dti-1331	402	12	m.j	m.j	PROPN
dti-1331	402	13	.	.	PROPN
dti-1331	402	14	1995	1995	NUM
dti-1331	402	15	.	.	PUNCT
dti-1331	403	1	beta	beta	NOUN
dti-1331	403	2	-	-	PUNCT
dti-1331	403	3	amyloid	amyloid	NOUN
dti-1331	403	4	selectively	selectively	ADV
dti-1331	403	5	augments	augment	VERB
dti-1331	403	6	nmda	nmda	ADJ
dti-1331	403	7	receptor	receptor	NOUN
dti-1331	403	8	-	-	PUNCT
dti-1331	403	9	mediated	mediate	VERB
dti-1331	403	10	synaptic	synaptic	ADJ
dti-1331	403	11	transmission	transmission	NOUN
dti-1331	403	12	in	in	ADP
dti-1331	403	13	rat	rat	NOUN
dti-1331	403	14	hippocampus	hippocampus	NOUN
dti-1331	403	15	.	.	PUNCT
dti-1331	404	1	neuroreport	neuroreport	NOUN
dti-1331	404	2	.	.	PROPN
dti-1331	404	3	,	,	PUNCT
dti-1331	404	4	6:2409–13	6:2409–13	NUM
dti-1331	404	5	.	.	PUNCT
dti-1331	405	1	<	<	X
dti-1331	405	2	<	<	X
dti-1331	405	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1331	405	4	false	false	ADJ
dti-1331	405	5	/allowtransparency	/allowtransparency	NOUN
dti-1331	405	6	false	false	ADJ
dti-1331	405	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1331	405	8	true	true	ADJ
dti-1331	405	9	/autorotatepages	/autorotatepage	NOUN
dti-1331	405	10	/none	/none	PUNCT
dti-1331	405	11	/binding	/binding	PUNCT
dti-1331	405	12	/left	/left	ADJ
dti-1331	406	1	/calgrayprofile	/calgrayprofile	VERB
dti-1331	406	2	(	(	PUNCT
dti-1331	406	3	dot	dot	NOUN
dti-1331	406	4	gain	gain	NOUN
dti-1331	406	5	20	20	NUM
dti-1331	406	6	%	%	NOUN
dti-1331	406	7	)	)	PUNCT
dti-1331	406	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1331	407	1	(	(	PUNCT
dti-1331	407	2	srgb	srgb	PROPN
dti-1331	407	3	iec61966	iec61966	NOUN
dti-1331	407	4	-	-	PUNCT
dti-1331	407	5	2.1	2.1	NUM
dti-1331	407	6	)	)	PUNCT
dti-1331	407	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1331	408	1	(	(	PUNCT
dti-1331	408	2	u.s	u.s	PROPN
dti-1331	408	3	.	.	PROPN
dti-1331	408	4	web	web	NOUN
dti-1331	408	5	coated	coat	VERB
dti-1331	408	6	\050swop\051	\050swop\051	ADJ
dti-1331	408	7	v2	v2	NOUN
dti-1331	408	8	)	)	PUNCT
dti-1331	408	9	/srgbprofile	/srgbprofile	PUNCT
dti-1331	408	10	(	(	PUNCT
dti-1331	408	11	srgb	srgb	PROPN
dti-1331	408	12	iec61966	iec61966	NOUN
dti-1331	408	13	-	-	PUNCT
dti-1331	408	14	2.1	2.1	NUM
dti-1331	408	15	)	)	PUNCT
dti-1331	408	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1331	409	1	/error	/error	INTJ
dti-1331	409	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1331	410	1	1.4	1.4	NUM
dti-1331	410	2	/compressobjects	/compressobject	NOUN
dti-1331	410	3	/tags	/tag	VERB
dti-1331	410	4	/compresspages	/compresspage	NOUN
dti-1331	410	5	true	true	ADJ
dti-1331	410	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1331	410	7	true	true	ADJ
dti-1331	410	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1331	410	9	true	true	ADJ
dti-1331	410	10	/createjdffile	/createjdffile	ADJ
dti-1331	410	11	false	false	ADJ
dti-1331	410	12	/createjobticket	/createjobticket	NOUN
dti-1331	410	13	false	false	ADJ
dti-1331	410	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1331	410	15	/default	/default	PUNCT
dti-1331	410	16	/detectblends	/detectblend	NOUN
dti-1331	410	17	true	true	ADJ
dti-1331	410	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1331	410	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1331	410	20	/dothumbnails	/dothumbnail	VERB
dti-1331	410	21	false	false	ADJ
dti-1331	410	22	/embedallfonts	/embedallfont	NOUN
dti-1331	410	23	true	true	ADJ
dti-1331	410	24	/embedjoboptions	/embedjoboption	NOUN
dti-1331	410	25	true	true	ADJ
dti-1331	410	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1331	410	27	0	0	NUM
dti-1331	410	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1331	410	29	false	false	ADJ
dti-1331	410	30	/endpage	/endpage	NOUN
dti-1331	410	31	-1	-1	NOUN
dti-1331	410	32	/imagememory	/imagememory	NUM
dti-1331	411	1	1048576	1048576	NUM
dti-1331	411	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1331	411	3	false	false	ADJ
dti-1331	411	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1331	411	5	100	100	NUM
dti-1331	411	6	/optimize	/optimize	NOUN
dti-1331	411	7	true	true	ADJ
dti-1331	411	8	/opm	/opm	NOUN
dti-1331	411	9	1	1	NUM
dti-1331	411	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1331	411	11	true	true	ADJ
dti-1331	411	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1331	411	13	true	true	ADJ
dti-1331	411	14	/preservecopypage	/preservecopypage	NOUN
dti-1331	411	15	true	true	ADJ
dti-1331	411	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1331	411	17	true	true	ADJ
dti-1331	411	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1331	411	19	false	false	ADJ
dti-1331	411	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1331	411	21	false	false	ADJ
dti-1331	411	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1331	411	23	true	true	ADJ
dti-1331	411	24	/startpage	/startpage	NOUN
dti-1331	411	25	1	1	NUM
dti-1331	411	26	/subsetfonts	/subsetfont	NOUN
dti-1331	411	27	true	true	ADJ
dti-1331	411	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1331	411	29	/apply	/apply	PUNCT
dti-1331	411	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1331	412	1	/preserve	/preserve	NOUN
dti-1331	412	2	/useprologue	/useprologue	NOUN
dti-1331	412	3	false	false	ADJ
dti-1331	412	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1331	412	5	(	(	PUNCT
dti-1331	412	6	)	)	PUNCT
dti-1331	412	7	/alwaysembed	/alwaysembe	VERB
dti-1331	412	8	[	[	PUNCT
dti-1331	412	9	true	true	ADJ
dti-1331	412	10	]	]	PUNCT
dti-1331	412	11	/neverembed	/neverembed	PUNCT
dti-1331	413	1	[	[	PUNCT
dti-1331	413	2	true	true	ADJ
dti-1331	413	3	]	]	PUNCT
dti-1331	413	4	/antialiascolorimages	/antialiascolorimages	X
dti-1331	413	5	false	false	ADJ
dti-1331	413	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1331	413	7	true	true	ADJ
dti-1331	413	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1331	413	9	/bicubic	/bicubic	NOUN
dti-1331	413	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1331	413	11	300	300	NUM
dti-1331	413	12	/colorimagedepth	/colorimagedepth	PRON
dti-1331	414	1	-1	-1	INTJ
dti-1331	414	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1331	414	3	1.50000	1.50000	NUM
dti-1331	414	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1331	414	5	true	true	ADJ
dti-1331	414	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1331	414	7	/dctencode	/dctencode	PUNCT
dti-1331	414	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1331	414	9	true	true	ADJ
dti-1331	414	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1331	414	11	/jpeg	/jpeg	PUNCT
dti-1331	414	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1331	415	1	<	<	X
dti-1331	415	2	<	<	X
dti-1331	415	3	/qfactor	/qfactor	NOUN
dti-1331	415	4	0.15	0.15	NUM
dti-1331	415	5	/hsamples	/hsample	NOUN
dti-1331	416	1	[	[	X
dti-1331	416	2	1	1	NUM
dti-1331	416	3	1	1	NUM
dti-1331	416	4	1	1	NUM
dti-1331	416	5	1	1	NUM
dti-1331	416	6	]	]	PUNCT
dti-1331	416	7	/vsamples	/vsample	NOUN
dti-1331	417	1	[	[	X
dti-1331	417	2	1	1	NUM
dti-1331	417	3	1	1	NUM
dti-1331	417	4	1	1	NUM
dti-1331	417	5	1	1	NUM
dti-1331	417	6	]	]	PUNCT
dti-1331	417	7	>	>	PUNCT
dti-1331	417	8	>	>	X
dti-1331	417	9	/colorimagedict	/colorimagedict	PUNCT
dti-1331	418	1	<	<	X
dti-1331	418	2	<	<	X
dti-1331	418	3	/qfactor	/qfactor	NOUN
dti-1331	418	4	0.15	0.15	NUM
dti-1331	418	5	/hsamples	/hsample	NOUN
dti-1331	419	1	[	[	X
dti-1331	419	2	1	1	NUM
dti-1331	419	3	1	1	NUM
dti-1331	419	4	1	1	NUM
dti-1331	419	5	1	1	NUM
dti-1331	419	6	]	]	PUNCT
dti-1331	419	7	/vsamples	/vsample	NOUN
dti-1331	420	1	[	[	X
dti-1331	420	2	1	1	NUM
dti-1331	420	3	1	1	NUM
dti-1331	420	4	1	1	NUM
dti-1331	420	5	1	1	NUM
dti-1331	420	6	]	]	PUNCT
dti-1331	420	7	>	>	PUNCT
dti-1331	420	8	>	>	X
dti-1331	420	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1331	421	1	<	<	X
dti-1331	421	2	<	<	X
dti-1331	421	3	/tilewidth	/tilewidth	PUNCT
dti-1331	421	4	256	256	NUM
dti-1331	421	5	/tileheight	/tileheight	NUM
dti-1331	421	6	256	256	NUM
dti-1331	421	7	/quality	/quality	NOUN
dti-1331	421	8	30	30	NUM
dti-1331	421	9	>	>	PUNCT
dti-1331	421	10	>	>	X
dti-1331	421	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1331	421	12	<	<	X
dti-1331	421	13	<	<	X
dti-1331	421	14	/tilewidth	/tilewidth	PUNCT
dti-1331	421	15	256	256	NUM
dti-1331	421	16	/tileheight	/tileheight	NUM
dti-1331	421	17	256	256	NUM
dti-1331	421	18	/quality	/quality	NOUN
dti-1331	421	19	30	30	NUM
dti-1331	421	20	>	>	PUNCT
dti-1331	421	21	>	>	X
dti-1331	421	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1331	421	23	false	false	ADJ
dti-1331	421	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1331	422	1	true	true	ADJ
dti-1331	422	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1331	422	3	/bicubic	/bicubic	NOUN
dti-1331	422	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1331	422	5	300	300	NUM
dti-1331	422	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1331	422	7	-1	-1	PUNCT
dti-1331	422	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1331	423	1	1.50000	1.50000	NUM
dti-1331	423	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1331	423	3	true	true	ADJ
dti-1331	423	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1331	423	5	/dctencode	/dctencode	PUNCT
dti-1331	424	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1331	424	2	true	true	ADJ
dti-1331	424	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1331	424	4	/jpeg	/jpeg	PUNCT
dti-1331	424	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1331	425	1	<	<	X
dti-1331	425	2	<	<	X
dti-1331	425	3	/qfactor	/qfactor	NOUN
dti-1331	425	4	0.15	0.15	NUM
dti-1331	425	5	/hsamples	/hsample	NOUN
dti-1331	426	1	[	[	X
dti-1331	426	2	1	1	NUM
dti-1331	426	3	1	1	NUM
dti-1331	426	4	1	1	NUM
dti-1331	426	5	1	1	NUM
dti-1331	426	6	]	]	PUNCT
dti-1331	426	7	/vsamples	/vsample	NOUN
dti-1331	427	1	[	[	X
dti-1331	427	2	1	1	NUM
dti-1331	427	3	1	1	NUM
dti-1331	427	4	1	1	NUM
dti-1331	427	5	1	1	NUM
dti-1331	427	6	]	]	PUNCT
dti-1331	427	7	>	>	PUNCT
dti-1331	427	8	>	>	X
dti-1331	427	9	/grayimagedict	/grayimagedict	PUNCT
dti-1331	428	1	<	<	X
dti-1331	428	2	<	<	X
dti-1331	428	3	/qfactor	/qfactor	NOUN
dti-1331	428	4	0.15	0.15	NUM
dti-1331	428	5	/hsamples	/hsample	NOUN
dti-1331	429	1	[	[	X
dti-1331	429	2	1	1	NUM
dti-1331	429	3	1	1	NUM
dti-1331	429	4	1	1	NUM
dti-1331	429	5	1	1	NUM
dti-1331	429	6	]	]	PUNCT
dti-1331	429	7	/vsamples	/vsample	NOUN
dti-1331	430	1	[	[	X
dti-1331	430	2	1	1	NUM
dti-1331	430	3	1	1	NUM
dti-1331	430	4	1	1	NUM
dti-1331	430	5	1	1	NUM
dti-1331	430	6	]	]	PUNCT
dti-1331	430	7	>	>	X
dti-1331	430	8	>	>	X
dti-1331	430	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1331	431	1	<	<	X
dti-1331	431	2	<	<	X
dti-1331	431	3	/tilewidth	/tilewidth	PUNCT
dti-1331	431	4	256	256	NUM
dti-1331	431	5	/tileheight	/tileheight	NUM
dti-1331	431	6	256	256	NUM
dti-1331	431	7	/quality	/quality	NOUN
dti-1331	431	8	30	30	NUM
dti-1331	431	9	>	>	PUNCT
dti-1331	431	10	>	>	X
dti-1331	431	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1331	431	12	<	<	X
dti-1331	431	13	<	<	X
dti-1331	431	14	/tilewidth	/tilewidth	PUNCT
dti-1331	431	15	256	256	NUM
dti-1331	431	16	/tileheight	/tileheight	NUM
dti-1331	431	17	256	256	NUM
dti-1331	431	18	/quality	/quality	NOUN
dti-1331	431	19	30	30	NUM
dti-1331	431	20	>	>	PUNCT
dti-1331	431	21	>	>	X
dti-1331	431	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1331	431	23	false	false	ADJ
dti-1331	431	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1331	431	25	true	true	ADJ
dti-1331	431	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1331	431	27	/bicubic	/bicubic	NOUN
dti-1331	431	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1331	431	29	1200	1200	NUM
dti-1331	431	30	/monoimagedepth	/monoimagedepth	PRON
dti-1331	431	31	-1	-1	PUNCT
dti-1331	431	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1331	431	33	1.50000	1.50000	NUM
dti-1331	431	34	/encodemonoimages	/encodemonoimage	NOUN
dti-1331	431	35	true	true	ADJ
dti-1331	431	36	/monoimagefilter	/monoimagefilter	ADP
dti-1331	431	37	/ccittfaxencode	/ccittfaxencode	INTJ
dti-1331	431	38	/monoimagedict	/monoimagedict	PUNCT
dti-1331	432	1	<	<	X
dti-1331	432	2	<	<	X
dti-1331	432	3	/k	/k	PUNCT
dti-1331	432	4	-1	-1	INTJ
dti-1331	432	5	>	>	PUNCT
dti-1331	432	6	>	>	X
dti-1331	432	7	/allowpsxobjects	/allowpsxobject	NOUN
dti-1331	433	1	false	false	ADJ
dti-1331	433	2	/pdfx1acheck	/pdfx1acheck	X
dti-1331	433	3	false	false	ADJ
dti-1331	433	4	/pdfx3check	/pdfx3check	PUNCT
dti-1331	433	5	false	false	ADJ
dti-1331	433	6	/pdfxcompliantpdfonly	/pdfxcompliantpdfonly	ADV
dti-1331	433	7	false	false	ADJ
dti-1331	433	8	/pdfxnotrimboxerror	/pdfxnotrimboxerror	NOUN
dti-1331	433	9	true	true	ADJ
dti-1331	433	10	/pdfxtrimboxtomediaboxoffset	/pdfxtrimboxtomediaboxoffset	NOUN
dti-1331	433	11	[	[	PUNCT
dti-1331	433	12	0.00000	0.00000	NUM
dti-1331	433	13	0.00000	0.00000	NUM
dti-1331	433	14	0.00000	0.00000	NUM
dti-1331	433	15	0.00000	0.00000	NUM
dti-1331	433	16	]	]	PUNCT
dti-1331	433	17	/pdfxsetbleedboxtomediabox	/pdfxsetbleedboxtomediabox	PUNCT
dti-1331	434	1	true	true	ADJ
dti-1331	434	2	/pdfxbleedboxtotrimboxoffset	/pdfxbleedboxtotrimboxoffset	PUNCT
dti-1331	434	3	[	[	PUNCT
dti-1331	434	4	0.00000	0.00000	NUM
dti-1331	434	5	0.00000	0.00000	NUM
dti-1331	434	6	0.00000	0.00000	NUM
dti-1331	434	7	0.00000	0.00000	NUM
dti-1331	434	8	]	]	PUNCT
dti-1331	434	9	/pdfxoutputintentprofile	/pdfxoutputintentprofile	PUNCT
dti-1331	435	1	(	(	PUNCT
dti-1331	435	2	)	)	PUNCT
dti-1331	435	3	/pdfxoutputcondition	/pdfxoutputcondition	PRON
dti-1331	435	4	(	(	PUNCT
dti-1331	435	5	)	)	PUNCT
dti-1331	435	6	/pdfxregistryname	/pdfxregistryname	PUNCT
dti-1331	435	7	(	(	PUNCT
dti-1331	435	8	http://www.color.org	http://www.color.org	PROPN
dti-1331	435	9	)	)	PUNCT
dti-1331	435	10	/pdfxtrapped	/pdfxtrapped	PUNCT
dti-1331	435	11	/unknown	/unknown	VERB
dti-1331	435	12	/description	/description	X
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dti-1331	436	3	/jpn	/jpn	PROPN
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dti-1331	436	7	/fra	/fra	PUNCT
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dti-1331	437	4	/deu	/deu	PUNCT
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dti-1331	438	3	>	>	X
dti-1331	438	4	/ptb	/ptb	PROPN
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dti-1331	440	3	/dan	/dan	PUNCT
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dti-1331	441	3	>	>	X
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dti-1331	442	3	>	>	X
dti-1331	442	4	/esp	/esp	PUNCT
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dti-1331	443	3	>	>	X
dti-1331	443	4	/suo	/suo	PUNCT
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dti-1331	444	3	>	>	X
dti-1331	444	4	/ita	/ita	PUNCT
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dti-1331	445	3	>	>	X
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