id	sid	tid	token	lemma	pos
dti-1332	1	1	prakash	prakash	PROPN
dti-1332	1	2	et	et	PROPN
dti-1332	1	3	al.indd	al.indd	PROPN
dti-1332	1	4	drug	drug	NOUN
dti-1332	1	5	target	target	NOUN
dti-1332	1	6	insights	insight	NOUN
dti-1332	1	7	2008:3	2008:3	NUM
dti-1332	1	8	99–117	99–117	NUM
dti-1332	1	9	99	99	NUM
dti-1332	1	10	review	review	NOUN
dti-1332	1	11	correspondence	correspondence	NOUN
dti-1332	1	12	:	:	PUNCT
dti-1332	1	13	dr	dr	PROPN
dti-1332	1	14	.	.	PROPN
dti-1332	1	15	satya	satya	PROPN
dti-1332	1	16	prakash	prakash	PROPN
dti-1332	1	17	,	,	PUNCT
dti-1332	1	18	biomedical	biomedical	ADJ
dti-1332	1	19	engineering	engineering	NOUN
dti-1332	1	20	,	,	PUNCT
dti-1332	1	21	faculty	faculty	NOUN
dti-1332	1	22	of	of	ADP
dti-1332	1	23	medicine	medicine	NOUN
dti-1332	1	24	,	,	PUNCT
dti-1332	1	25	mcgill	mcgill	PROPN
dti-1332	1	26	university	university	PROPN
dti-1332	1	27	,	,	PUNCT
dti-1332	1	28	3775	3775	NUM
dti-1332	1	29	,	,	PUNCT
dti-1332	1	30	university	university	NOUN
dti-1332	1	31	street	street	NOUN
dti-1332	1	32	,	,	PUNCT
dti-1332	1	33	montréal	montréal	PROPN
dti-1332	1	34	,	,	PUNCT
dti-1332	1	35	qc	qc	PROPN
dti-1332	1	36	,	,	PUNCT
dti-1332	1	37	h3a	h3a	NOUN
dti-1332	1	38	2b4	2b4	NUM
dti-1332	1	39	,	,	PUNCT
dti-1332	1	40	canada	canada	PROPN
dti-1332	1	41	.	.	PUNCT
dti-1332	2	1	fax	fax	NOUN
dti-1332	2	2	:	:	PUNCT
dti-1332	2	3	514	514	NUM
dti-1332	2	4	-	-	SYM
dti-1332	2	5	398	398	NUM
dti-1332	2	6	-	-	SYM
dti-1332	2	7	7461	7461	NUM
dti-1332	2	8	;	;	PUNCT
dti-1332	2	9	email	email	NOUN
dti-1332	2	10	:	:	PUNCT
dti-1332	2	11	satya.prakash@mcgill.ca	satya.prakash@mcgill.ca	VERB
dti-1332	2	12	copyright	copyright	NOUN
dti-1332	2	13	in	in	ADP
dti-1332	2	14	this	this	DET
dti-1332	2	15	article	article	NOUN
dti-1332	2	16	,	,	PUNCT
dti-1332	2	17	its	its	PRON
dti-1332	2	18	metadata	metadata	NOUN
dti-1332	2	19	,	,	PUNCT
dti-1332	2	20	and	and	CCONJ
dti-1332	2	21	any	any	DET
dti-1332	2	22	supplementary	supplementary	ADJ
dti-1332	2	23	data	datum	NOUN
dti-1332	2	24	is	be	AUX
dti-1332	2	25	held	hold	VERB
dti-1332	2	26	by	by	ADP
dti-1332	2	27	its	its	PRON
dti-1332	2	28	author	author	NOUN
dti-1332	2	29	or	or	CCONJ
dti-1332	2	30	authors	author	NOUN
dti-1332	2	31	.	.	PUNCT
dti-1332	3	1	it	it	PRON
dti-1332	3	2	is	be	AUX
dti-1332	3	3	published	publish	VERB
dti-1332	3	4	under	under	ADP
dti-1332	3	5	the	the	DET
dti-1332	3	6	creative	creative	ADJ
dti-1332	3	7	commons	common	NOUN
dti-1332	3	8	attribution	attribution	NOUN
dti-1332	3	9	by	by	ADP
dti-1332	3	10	licence	licence	NOUN
dti-1332	3	11	.	.	PUNCT
dti-1332	4	1	for	for	SCONJ
dti-1332	4	2	further	further	ADJ
dti-1332	4	3	information	information	NOUN
dti-1332	4	4	go	go	VERB
dti-1332	4	5	to	to	ADP
dti-1332	4	6	:	:	PUNCT
dti-1332	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1332	4	8	recent	recent	ADJ
dti-1332	4	9	advancements	advancement	NOUN
dti-1332	4	10	in	in	ADP
dti-1332	4	11	targeted	target	VERB
dti-1332	4	12	delivery	delivery	NOUN
dti-1332	4	13	of	of	ADP
dti-1332	4	14	therapeutic	therapeutic	ADJ
dti-1332	4	15	molecules	molecule	NOUN
dti-1332	4	16	in	in	ADP
dti-1332	4	17	neurodegenerative	neurodegenerative	ADJ
dti-1332	4	18	disease	disease	NOUN
dti-1332	4	19	—	—	PUNCT
dti-1332	4	20	spinocerebellar	spinocerebellar	ADJ
dti-1332	4	21	ataxia	ataxia	NOUN
dti-1332	4	22	—	—	PUNCT
dti-1332	4	23	opportunities	opportunity	NOUN
dti-1332	4	24	and	and	CCONJ
dti-1332	4	25	challenges	challenge	VERB
dti-1332	4	26	satya	satya	PROPN
dti-1332	4	27	prakash	prakash	PROPN
dti-1332	4	28	and	and	CCONJ
dti-1332	4	29	meenakshi	meenakshi	PROPN
dti-1332	4	30	malhotra	malhotra	PROPN
dti-1332	4	31	biomedical	biomedical	PROPN
dti-1332	4	32	technology	technology	NOUN
dti-1332	4	33	and	and	CCONJ
dti-1332	4	34	cell	cell	NOUN
dti-1332	4	35	therapy	therapy	NOUN
dti-1332	4	36	research	research	NOUN
dti-1332	4	37	laboratory	laboratory	NOUN
dti-1332	4	38	,	,	PUNCT
dti-1332	4	39	departments	department	NOUN
dti-1332	4	40	of	of	ADP
dti-1332	4	41	biomedical	biomedical	ADJ
dti-1332	4	42	engineering	engineering	NOUN
dti-1332	4	43	and	and	CCONJ
dti-1332	4	44	physiology	physiology	NOUN
dti-1332	4	45	,	,	PUNCT
dti-1332	4	46	artificial	artificial	ADJ
dti-1332	4	47	cells	cell	NOUN
dti-1332	4	48	and	and	CCONJ
dti-1332	4	49	organs	organ	NOUN
dti-1332	4	50	research	research	NOUN
dti-1332	4	51	center	center	NOUN
dti-1332	4	52	,	,	PUNCT
dti-1332	4	53	faculty	faculty	NOUN
dti-1332	4	54	of	of	ADP
dti-1332	4	55	medicine	medicine	NOUN
dti-1332	4	56	,	,	PUNCT
dti-1332	4	57	mcgill	mcgill	PROPN
dti-1332	4	58	university	university	PROPN
dti-1332	4	59	,	,	PUNCT
dti-1332	4	60	3775	3775	NUM
dti-1332	4	61	university	university	NOUN
dti-1332	4	62	street	street	NOUN
dti-1332	4	63	,	,	PUNCT
dti-1332	4	64	montreal	montreal	PROPN
dti-1332	4	65	,	,	PUNCT
dti-1332	4	66	quebec	quebec	PROPN
dti-1332	4	67	,	,	PUNCT
dti-1332	4	68	h3a	h3a	X
dti-1332	4	69	2b4	2b4	NUM
dti-1332	4	70	,	,	PUNCT
dti-1332	4	71	canada	canada	PROPN
dti-1332	4	72	.	.	PUNCT
dti-1332	5	1	abstract	abstract	ADJ
dti-1332	5	2	:	:	PUNCT
dti-1332	5	3	drug	drug	NOUN
dti-1332	5	4	discovery	discovery	NOUN
dti-1332	5	5	and	and	CCONJ
dti-1332	5	6	its	its	PRON
dti-1332	5	7	methodologies	methodology	NOUN
dti-1332	5	8	have	have	AUX
dti-1332	5	9	been	be	AUX
dti-1332	5	10	very	very	ADV
dti-1332	5	11	effective	effective	ADJ
dti-1332	5	12	in	in	ADP
dti-1332	5	13	terms	term	NOUN
dti-1332	5	14	of	of	ADP
dti-1332	5	15	treating	treat	VERB
dti-1332	5	16	cancers	cancer	NOUN
dti-1332	5	17	and	and	CCONJ
dti-1332	5	18	immunological	immunological	ADJ
dti-1332	5	19	disorders	disorder	NOUN
dti-1332	5	20	but	but	CCONJ
dti-1332	5	21	have	have	AUX
dti-1332	5	22	not	not	PART
dti-1332	5	23	been	be	AUX
dti-1332	5	24	able	able	ADJ
dti-1332	5	25	to	to	PART
dti-1332	5	26	stop	stop	VERB
dti-1332	5	27	genetic	genetic	ADJ
dti-1332	5	28	diseases	disease	NOUN
dti-1332	5	29	as	as	ADP
dti-1332	5	30	most	most	ADJ
dti-1332	5	31	of	of	ADP
dti-1332	5	32	the	the	DET
dti-1332	5	33	drugs	drug	NOUN
dti-1332	5	34	target	target	NOUN
dti-1332	5	35	at	at	ADP
dti-1332	5	36	the	the	DET
dti-1332	5	37	protein	protein	NOUN
dti-1332	5	38	level	level	NOUN
dti-1332	5	39	.	.	PUNCT
dti-1332	6	1	they	they	PRON
dti-1332	6	2	merely	merely	ADV
dti-1332	6	3	mitigate	mitigate	VERB
dti-1332	6	4	the	the	DET
dti-1332	6	5	symptoms	symptom	NOUN
dti-1332	6	6	of	of	ADP
dti-1332	6	7	the	the	DET
dti-1332	6	8	disease	disease	NOUN
dti-1332	6	9	.	.	PUNCT
dti-1332	7	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	7	2	ataxia	ataxia	NOUN
dti-1332	7	3	is	be	AUX
dti-1332	7	4	a	a	DET
dti-1332	7	5	neurological	neurological	ADJ
dti-1332	7	6	genetic	genetic	ADJ
dti-1332	7	7	disorder	disorder	NOUN
dti-1332	7	8	that	that	PRON
dti-1332	7	9	is	be	AUX
dti-1332	7	10	caused	cause	VERB
dti-1332	7	11	by	by	ADP
dti-1332	7	12	the	the	DET
dti-1332	7	13	formation	formation	NOUN
dti-1332	7	14	of	of	ADP
dti-1332	7	15	an	an	DET
dti-1332	7	16	abnormal	abnormal	ADJ
dti-1332	7	17	protein	protein	NOUN
dti-1332	7	18	.	.	PUNCT
dti-1332	8	1	there	there	PRON
dti-1332	8	2	have	have	AUX
dti-1332	8	3	been	be	AUX
dti-1332	8	4	several	several	ADJ
dti-1332	8	5	reports	report	NOUN
dti-1332	8	6	on	on	ADP
dti-1332	8	7	ataxic	ataxic	ADJ
dti-1332	8	8	drug	drug	NOUN
dti-1332	8	9	development	development	NOUN
dti-1332	8	10	but	but	CCONJ
dti-1332	8	11	actual	actual	ADJ
dti-1332	8	12	clinical	clinical	ADJ
dti-1332	8	13	treatment	treatment	NOUN
dti-1332	8	14	is	be	AUX
dti-1332	8	15	yet	yet	ADV
dti-1332	8	16	to	to	PART
dti-1332	8	17	be	be	AUX
dti-1332	8	18	achieved	achieve	VERB
dti-1332	8	19	.	.	PUNCT
dti-1332	9	1	oligonucleotide	oligonucleotide	NOUN
dti-1332	9	2	therapy	therapy	NOUN
dti-1332	9	3	called	call	VERB
dti-1332	9	4	sequence	sequence	NOUN
dti-1332	9	5	specifi	specifi	PROPN
dti-1332	9	6	c	c	PROPN
dti-1332	9	7	sirna	sirna	PROPN
dti-1332	9	8	mediated	mediate	VERB
dti-1332	9	9	gene	gene	NOUN
dti-1332	9	10	silencing	silence	VERB
dti-1332	9	11	has	have	AUX
dti-1332	9	12	evolved	evolve	VERB
dti-1332	9	13	with	with	ADP
dti-1332	9	14	promising	promising	ADJ
dti-1332	9	15	results	result	NOUN
dti-1332	9	16	.	.	PUNCT
dti-1332	10	1	this	this	DET
dti-1332	10	2	approach	approach	NOUN
dti-1332	10	3	emphasizes	emphasize	VERB
dti-1332	10	4	on	on	ADP
dti-1332	10	5	suppressing	suppress	VERB
dti-1332	10	6	the	the	DET
dti-1332	10	7	expression	expression	NOUN
dti-1332	10	8	of	of	ADP
dti-1332	10	9	the	the	DET
dti-1332	10	10	diseased	diseased	ADJ
dti-1332	10	11	gene	gene	NOUN
dti-1332	10	12	at	at	ADP
dti-1332	10	13	mrna	mrna	PROPN
dti-1332	10	14	level	level	NOUN
dti-1332	10	15	.	.	PUNCT
dti-1332	11	1	however	however	ADV
dti-1332	11	2	,	,	PUNCT
dti-1332	11	3	there	there	PRON
dti-1332	11	4	is	be	VERB
dti-1332	11	5	a	a	DET
dti-1332	11	6	limitation	limitation	NOUN
dti-1332	11	7	in	in	ADP
dti-1332	11	8	delivery	delivery	NOUN
dti-1332	11	9	of	of	ADP
dti-1332	11	10	sirna	sirna	PROPN
dti-1332	11	11	to	to	ADP
dti-1332	11	12	the	the	DET
dti-1332	11	13	target	target	NOUN
dti-1332	11	14	site	site	NOUN
dti-1332	11	15	.	.	PUNCT
dti-1332	12	1	several	several	ADJ
dti-1332	12	2	methods	method	NOUN
dti-1332	12	3	have	have	AUX
dti-1332	12	4	been	be	AUX
dti-1332	12	5	developed	develop	VERB
dti-1332	12	6	over	over	ADP
dti-1332	12	7	the	the	DET
dti-1332	12	8	last	last	ADJ
dti-1332	12	9	decade	decade	NOUN
dti-1332	12	10	to	to	PART
dti-1332	12	11	enhance	enhance	VERB
dti-1332	12	12	the	the	DET
dti-1332	12	13	target	target	NOUN
dti-1332	12	14	specifi	specifi	PROPN
dti-1332	12	15	c	c	PROPN
dti-1332	12	16	delivery	delivery	NOUN
dti-1332	12	17	of	of	ADP
dti-1332	12	18	dna	dna	PROPN
dti-1332	12	19	,	,	PUNCT
dti-1332	12	20	sirna	sirna	PROPN
dti-1332	12	21	,	,	PUNCT
dti-1332	12	22	protein	protein	NOUN
dti-1332	12	23	and	and	CCONJ
dti-1332	12	24	small	small	ADJ
dti-1332	12	25	drug	drug	NOUN
dti-1332	12	26	molecules	molecule	NOUN
dti-1332	12	27	for	for	ADP
dti-1332	12	28	therapeutic	therapeutic	ADJ
dti-1332	12	29	purpose	purpose	NOUN
dti-1332	12	30	with	with	ADP
dti-1332	12	31	less	less	ADJ
dti-1332	12	32	or	or	CCONJ
dti-1332	12	33	no	no	PRON
dti-1332	12	34	side	side	NOUN
dti-1332	12	35	effects	effect	NOUN
dti-1332	12	36	.	.	PUNCT
dti-1332	13	1	this	this	DET
dti-1332	13	2	review	review	NOUN
dti-1332	13	3	discusses	discuss	VERB
dti-1332	13	4	the	the	DET
dti-1332	13	5	latest	late	ADJ
dti-1332	13	6	upcoming	upcoming	ADJ
dti-1332	13	7	technologies	technology	NOUN
dti-1332	13	8	in	in	ADP
dti-1332	13	9	the	the	DET
dti-1332	13	10	fi	fi	NOUN
dti-1332	13	11	eld	eld	NOUN
dti-1332	13	12	that	that	PRON
dti-1332	13	13	focus	focus	VERB
dti-1332	13	14	on	on	ADP
dti-1332	13	15	a	a	DET
dti-1332	13	16	number	number	NOUN
dti-1332	13	17	of	of	ADP
dti-1332	13	18	nonviral	nonviral	ADJ
dti-1332	13	19	nanocarriers	nanocarrier	NOUN
dti-1332	13	20	for	for	ADP
dti-1332	13	21	targeted	target	VERB
dti-1332	13	22	delivery	delivery	NOUN
dti-1332	13	23	.	.	PUNCT
dti-1332	14	1	in	in	ADP
dti-1332	14	2	this	this	DET
dti-1332	14	3	review	review	NOUN
dti-1332	14	4	,	,	PUNCT
dti-1332	14	5	we	we	PRON
dti-1332	14	6	explore	explore	VERB
dti-1332	14	7	the	the	DET
dti-1332	14	8	promise	promise	NOUN
dti-1332	14	9	and	and	CCONJ
dti-1332	14	10	potential	potential	NOUN
dti-1332	14	11	of	of	ADP
dti-1332	14	12	novel	novel	ADJ
dti-1332	14	13	therapeutics	therapeutic	NOUN
dti-1332	14	14	with	with	ADP
dti-1332	14	15	interest	interest	NOUN
dti-1332	14	16	on	on	ADP
dti-1332	14	17	ataxia	ataxia	NOUN
dti-1332	14	18	therapy	therapy	NOUN
dti-1332	14	19	.	.	PUNCT
dti-1332	15	1	keywords	keyword	NOUN
dti-1332	15	2	:	:	PUNCT
dti-1332	15	3	neurodegeneration	neurodegeneration	ADJ
dti-1332	15	4	,	,	PUNCT
dti-1332	15	5	neurodegenerative	neurodegenerative	ADJ
dti-1332	15	6	diseases	disease	NOUN
dti-1332	15	7	,	,	PUNCT
dti-1332	15	8	spinocerebellar	spinocerebellar	ADJ
dti-1332	15	9	ataxia	ataxia	NOUN
dti-1332	15	10	,	,	PUNCT
dti-1332	15	11	gene	gene	NOUN
dti-1332	15	12	silencing	silencing	NOUN
dti-1332	15	13	,	,	PUNCT
dti-1332	15	14	nanoparticles	nanoparticle	NOUN
dti-1332	15	15	,	,	PUNCT
dti-1332	15	16	targeted	target	VERB
dti-1332	15	17	delivery	delivery	NOUN
dti-1332	15	18	introduction	introduction	NOUN
dti-1332	15	19	the	the	DET
dti-1332	15	20	dna	dna	NOUN
dti-1332	15	21	,	,	PUNCT
dti-1332	15	22	a	a	DET
dti-1332	15	23	vital	vital	ADJ
dti-1332	15	24	biomolecule	biomolecule	NOUN
dti-1332	15	25	of	of	ADP
dti-1332	15	26	a	a	DET
dti-1332	15	27	living	live	VERB
dti-1332	15	28	organism	organism	NOUN
dti-1332	15	29	,	,	PUNCT
dti-1332	15	30	contains	contain	VERB
dti-1332	15	31	a	a	DET
dti-1332	15	32	set	set	NOUN
dti-1332	15	33	of	of	ADP
dti-1332	15	34	information	information	NOUN
dti-1332	15	35	coded	code	VERB
dti-1332	15	36	in	in	ADP
dti-1332	15	37	the	the	DET
dti-1332	15	38	form	form	NOUN
dti-1332	15	39	of	of	ADP
dti-1332	15	40	nucleotides	nucleotide	NOUN
dti-1332	15	41	and	and	CCONJ
dti-1332	15	42	is	be	AUX
dti-1332	15	43	passed	pass	VERB
dti-1332	15	44	from	from	ADP
dti-1332	15	45	generation	generation	NOUN
dti-1332	15	46	to	to	ADP
dti-1332	15	47	generation	generation	NOUN
dti-1332	15	48	,	,	PUNCT
dti-1332	15	49	but	but	CCONJ
dti-1332	15	50	still	still	ADV
dti-1332	15	51	no	no	DET
dti-1332	15	52	two	two	NUM
dti-1332	15	53	individuals	individual	NOUN
dti-1332	15	54	are	be	AUX
dti-1332	15	55	alike	alike	ADJ
dti-1332	15	56	because	because	SCONJ
dti-1332	15	57	this	this	DET
dti-1332	15	58	set	set	NOUN
dti-1332	15	59	of	of	ADP
dti-1332	15	60	information	information	NOUN
dti-1332	15	61	is	be	AUX
dti-1332	15	62	made	make	VERB
dti-1332	15	63	from	from	ADP
dti-1332	15	64	the	the	DET
dti-1332	15	65	combination	combination	NOUN
dti-1332	15	66	of	of	ADP
dti-1332	15	67	two	two	NUM
dti-1332	15	68	different	different	ADJ
dti-1332	15	69	individuals	individual	NOUN
dti-1332	15	70	.	.	PUNCT
dti-1332	16	1	this	this	DET
dti-1332	16	2	type	type	NOUN
dti-1332	16	3	of	of	ADP
dti-1332	16	4	permutation	permutation	NOUN
dti-1332	16	5	and	and	CCONJ
dti-1332	16	6	combination	combination	NOUN
dti-1332	16	7	results	result	NOUN
dti-1332	16	8	in	in	ADP
dti-1332	16	9	a	a	DET
dti-1332	16	10	gene	gene	NOUN
dti-1332	16	11	pool	pool	NOUN
dti-1332	16	12	and	and	CCONJ
dti-1332	16	13	the	the	DET
dti-1332	16	14	dominant	dominant	ADJ
dti-1332	16	15	traits	trait	NOUN
dti-1332	16	16	are	be	AUX
dti-1332	16	17	positively	positively	ADV
dti-1332	16	18	selected	select	VERB
dti-1332	16	19	by	by	ADP
dti-1332	16	20	natural	natural	ADJ
dti-1332	16	21	selection	selection	NOUN
dti-1332	16	22	because	because	SCONJ
dti-1332	16	23	of	of	ADP
dti-1332	16	24	their	their	PRON
dti-1332	16	25	enhanced	enhance	VERB
dti-1332	16	26	capability	capability	NOUN
dti-1332	16	27	of	of	ADP
dti-1332	16	28	surviving	surviving	NOUN
dti-1332	16	29	,	,	PUNCT
dti-1332	16	30	or	or	CCONJ
dti-1332	16	31	their	their	PRON
dti-1332	16	32	competency	competency	NOUN
dti-1332	16	33	and	and	CCONJ
dti-1332	16	34	favorable	favorable	ADJ
dti-1332	16	35	environmental	environmental	ADJ
dti-1332	16	36	conditions	condition	NOUN
dti-1332	16	37	.	.	PUNCT
dti-1332	17	1	such	such	ADJ
dti-1332	17	2	dominant	dominant	ADJ
dti-1332	17	3	characters	character	NOUN
dti-1332	17	4	need	need	AUX
dti-1332	17	5	not	not	PART
dti-1332	17	6	always	always	ADV
dti-1332	17	7	be	be	AUX
dti-1332	17	8	benefi	benefi	ADJ
dti-1332	17	9	cial	cial	NOUN
dti-1332	17	10	for	for	ADP
dti-1332	17	11	an	an	DET
dti-1332	17	12	individual	individual	NOUN
dti-1332	17	13	as	as	SCONJ
dti-1332	17	14	they	they	PRON
dti-1332	17	15	could	could	AUX
dti-1332	17	16	be	be	AUX
dti-1332	17	17	problematic	problematic	ADJ
dti-1332	17	18	too	too	ADV
dti-1332	17	19	.	.	PUNCT
dti-1332	18	1	mutational	mutational	ADJ
dti-1332	18	2	events	event	NOUN
dti-1332	18	3	like	like	ADP
dti-1332	18	4	deletion	deletion	NOUN
dti-1332	18	5	,	,	PUNCT
dti-1332	18	6	insertion	insertion	NOUN
dti-1332	18	7	,	,	PUNCT
dti-1332	18	8	polymorphisms	polymorphism	NOUN
dti-1332	18	9	and	and	CCONJ
dti-1332	18	10	inversions	inversion	NOUN
dti-1332	18	11	produce	produce	VERB
dti-1332	18	12	such	such	ADJ
dti-1332	18	13	defective	defective	ADJ
dti-1332	18	14	features	feature	NOUN
dti-1332	18	15	.	.	PUNCT
dti-1332	19	1	such	such	ADJ
dti-1332	19	2	mutations	mutation	NOUN
dti-1332	19	3	if	if	SCONJ
dti-1332	19	4	dominant	dominant	ADJ
dti-1332	19	5	in	in	ADP
dti-1332	19	6	character	character	NOUN
dti-1332	19	7	are	be	AUX
dti-1332	19	8	mostly	mostly	ADV
dti-1332	19	9	inheritable	inheritable	ADJ
dti-1332	19	10	and	and	CCONJ
dti-1332	19	11	form	form	VERB
dti-1332	19	12	the	the	DET
dti-1332	19	13	major	major	ADJ
dti-1332	19	14	causes	cause	NOUN
dti-1332	19	15	of	of	ADP
dti-1332	19	16	genetically	genetically	ADV
dti-1332	19	17	inherited	inherit	VERB
dti-1332	19	18	diseases	disease	NOUN
dti-1332	19	19	.	.	PUNCT
dti-1332	20	1	the	the	DET
dti-1332	20	2	cell	cell	NOUN
dti-1332	20	3	’s	’s	PART
dti-1332	20	4	machinery	machinery	NOUN
dti-1332	20	5	also	also	ADV
dti-1332	20	6	has	have	VERB
dti-1332	20	7	some	some	DET
dti-1332	20	8	internal	internal	ADJ
dti-1332	20	9	checks	check	NOUN
dti-1332	20	10	and	and	CCONJ
dti-1332	20	11	safety	safety	NOUN
dti-1332	20	12	mechanisms	mechanism	NOUN
dti-1332	20	13	to	to	PART
dti-1332	20	14	counteract	counteract	VERB
dti-1332	20	15	such	such	ADJ
dti-1332	20	16	unintentional	unintentional	ADJ
dti-1332	20	17	lethalities	lethality	NOUN
dti-1332	20	18	,	,	PUNCT
dti-1332	20	19	amongst	amongst	ADP
dti-1332	20	20	them	they	PRON
dti-1332	20	21	is	be	AUX
dti-1332	20	22	the	the	DET
dti-1332	20	23	mechanism	mechanism	NOUN
dti-1332	20	24	of	of	ADP
dti-1332	20	25	rna	rna	NOUN
dti-1332	20	26	interference	interference	NOUN
dti-1332	20	27	(	(	PUNCT
dti-1332	20	28	rnai	rnai	PROPN
dti-1332	20	29	)	)	PUNCT
dti-1332	20	30	,	,	PUNCT
dti-1332	20	31	which	which	PRON
dti-1332	20	32	is	be	AUX
dti-1332	20	33	fast	fast	ADV
dti-1332	20	34	gaining	gain	VERB
dti-1332	20	35	prominence	prominence	NOUN
dti-1332	20	36	for	for	ADP
dti-1332	20	37	its	its	PRON
dti-1332	20	38	potential	potential	NOUN
dti-1332	20	39	in	in	ADP
dti-1332	20	40	therapeutic	therapeutic	ADJ
dti-1332	20	41	applications	application	NOUN
dti-1332	20	42	.	.	PUNCT
dti-1332	21	1	the	the	DET
dti-1332	21	2	application	application	NOUN
dti-1332	21	3	of	of	ADP
dti-1332	21	4	rnai	rnai	PROPN
dti-1332	21	5	as	as	ADP
dti-1332	21	6	a	a	DET
dti-1332	21	7	novel	novel	ADJ
dti-1332	21	8	therapeutic	therapeutic	ADJ
dti-1332	21	9	modality	modality	NOUN
dti-1332	21	10	depends	depend	VERB
dti-1332	21	11	on	on	ADP
dti-1332	21	12	the	the	DET
dti-1332	21	13	development	development	NOUN
dti-1332	21	14	of	of	ADP
dti-1332	21	15	an	an	DET
dti-1332	21	16	effi	effi	PROPN
dti-1332	21	17	cient	cient	NOUN
dti-1332	21	18	and	and	CCONJ
dti-1332	21	19	clinically	clinically	ADV
dti-1332	21	20	feasible	feasible	ADJ
dti-1332	21	21	means	mean	NOUN
dti-1332	21	22	for	for	ADP
dti-1332	21	23	sirna	sirna	PROPN
dti-1332	21	24	delivery	delivery	PROPN
dti-1332	21	25	and	and	CCONJ
dti-1332	21	26	administration	administration	NOUN
dti-1332	21	27	.	.	PUNCT
dti-1332	22	1	various	various	ADJ
dti-1332	22	2	delivery	delivery	NOUN
dti-1332	22	3	methods	method	NOUN
dti-1332	22	4	have	have	AUX
dti-1332	22	5	been	be	AUX
dti-1332	22	6	employed	employ	VERB
dti-1332	22	7	to	to	PART
dti-1332	22	8	deliver	deliver	VERB
dti-1332	22	9	such	such	ADJ
dti-1332	22	10	therapeutic	therapeutic	ADJ
dti-1332	22	11	molecules	molecule	NOUN
dti-1332	22	12	resulting	result	VERB
dti-1332	22	13	in	in	ADP
dti-1332	22	14	on	on	ADP
dti-1332	22	15	-	-	PUNCT
dti-1332	22	16	target	target	NOUN
dti-1332	22	17	effi	effi	PROPN
dti-1332	22	18	cient	cient	NOUN
dti-1332	22	19	gene	gene	NOUN
dti-1332	22	20	silencing	silence	VERB
dti-1332	22	21	.	.	PUNCT
dti-1332	23	1	the	the	DET
dti-1332	23	2	research	research	NOUN
dti-1332	23	3	focuses	focus	VERB
dti-1332	23	4	to	to	PART
dti-1332	23	5	understand	understand	VERB
dti-1332	23	6	the	the	DET
dti-1332	23	7	intricacies	intricacy	NOUN
dti-1332	23	8	of	of	ADP
dti-1332	23	9	our	our	PRON
dti-1332	23	10	biological	biological	ADJ
dti-1332	23	11	system	system	NOUN
dti-1332	23	12	.	.	PUNCT
dti-1332	24	1	the	the	DET
dti-1332	24	2	immune	immune	ADJ
dti-1332	24	3	mechanism	mechanism	NOUN
dti-1332	24	4	that	that	PRON
dti-1332	24	5	guards	guard	VERB
dti-1332	24	6	our	our	PRON
dti-1332	24	7	system	system	NOUN
dti-1332	24	8	is	be	AUX
dti-1332	24	9	intelligent	intelligent	ADJ
dti-1332	24	10	to	to	PART
dti-1332	24	11	shoot	shoot	VERB
dti-1332	24	12	out	out	ADP
dti-1332	24	13	all	all	DET
dti-1332	24	14	the	the	DET
dti-1332	24	15	invaders	invader	NOUN
dti-1332	24	16	but	but	CCONJ
dti-1332	24	17	the	the	DET
dti-1332	24	18	invaders	invader	NOUN
dti-1332	24	19	are	be	AUX
dti-1332	24	20	more	more	ADV
dti-1332	24	21	intelligent	intelligent	ADJ
dti-1332	24	22	.	.	PUNCT
dti-1332	25	1	their	their	PRON
dti-1332	25	2	unique	unique	ADJ
dti-1332	25	3	characteristics	characteristic	NOUN
dti-1332	25	4	allow	allow	VERB
dti-1332	25	5	them	they	PRON
dti-1332	25	6	to	to	PART
dti-1332	25	7	easily	easily	ADV
dti-1332	25	8	evade	evade	VERB
dti-1332	25	9	,	,	PUNCT
dti-1332	25	10	cross	cross	VERB
dti-1332	25	11	barriers	barrier	NOUN
dti-1332	25	12	and	and	CCONJ
dti-1332	25	13	reach	reach	VERB
dti-1332	25	14	their	their	PRON
dti-1332	25	15	targets	target	NOUN
dti-1332	25	16	.	.	PUNCT
dti-1332	26	1	such	such	ADJ
dti-1332	26	2	invading	invade	VERB
dti-1332	26	3	systems	system	NOUN
dti-1332	26	4	have	have	AUX
dti-1332	26	5	led	lead	VERB
dti-1332	26	6	researchers	researcher	NOUN
dti-1332	26	7	to	to	PART
dti-1332	26	8	mimic	mimic	VERB
dti-1332	26	9	their	their	PRON
dti-1332	26	10	natural	natural	ADJ
dti-1332	26	11	characteristic	characteristic	NOUN
dti-1332	26	12	and	and	CCONJ
dti-1332	26	13	design	design	VERB
dti-1332	26	14	a	a	DET
dti-1332	26	15	therapeutic	therapeutic	ADJ
dti-1332	26	16	system	system	NOUN
dti-1332	26	17	that	that	PRON
dti-1332	26	18	may	may	AUX
dti-1332	26	19	cross	cross	VERB
dti-1332	26	20	all	all	DET
dti-1332	26	21	the	the	DET
dti-1332	26	22	barriers	barrier	NOUN
dti-1332	26	23	and	and	CCONJ
dti-1332	26	24	reach	reach	VERB
dti-1332	26	25	the	the	DET
dti-1332	26	26	affected	affect	VERB
dti-1332	26	27	target	target	NOUN
dti-1332	26	28	without	without	ADP
dti-1332	26	29	meddling	meddle	VERB
dti-1332	26	30	with	with	ADP
dti-1332	26	31	the	the	DET
dti-1332	26	32	normal	normal	ADJ
dti-1332	26	33	biological	biological	ADJ
dti-1332	26	34	functions	function	NOUN
dti-1332	26	35	.	.	PUNCT
dti-1332	27	1	modern	modern	ADJ
dti-1332	27	2	science	science	NOUN
dti-1332	27	3	recognizes	recognize	VERB
dti-1332	27	4	these	these	DET
dti-1332	27	5	intelligent	intelligent	ADJ
dti-1332	27	6	molecules	molecule	NOUN
dti-1332	27	7	as	as	ADP
dti-1332	27	8	biomimetics	biomimetic	NOUN
dti-1332	27	9	.	.	PUNCT
dti-1332	28	1	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	PROPN
dti-1332	28	2	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	PROPN
dti-1332	28	3	100	100	NUM
dti-1332	28	4	prakash	prakash	PROPN
dti-1332	28	5	and	and	CCONJ
dti-1332	28	6	malhotra	malhotra	PROPN
dti-1332	28	7	drug	drug	PROPN
dti-1332	28	8	target	target	NOUN
dti-1332	28	9	insights	insight	NOUN
dti-1332	28	10	2008:3	2008:3	NUM
dti-1332	28	11	in	in	ADP
dti-1332	28	12	this	this	DET
dti-1332	28	13	review	review	NOUN
dti-1332	28	14	,	,	PUNCT
dti-1332	28	15	we	we	PRON
dti-1332	28	16	focus	focus	VERB
dti-1332	28	17	on	on	ADP
dti-1332	28	18	genetically	genetically	ADV
dti-1332	28	19	inherited	inherit	VERB
dti-1332	28	20	neurodegenerative	neurodegenerative	ADJ
dti-1332	28	21	disease	disease	NOUN
dti-1332	28	22	,	,	PUNCT
dti-1332	28	23	spinocerebellar	spinocerebellar	ADJ
dti-1332	28	24	ataxia	ataxia	NOUN
dti-1332	28	25	and	and	CCONJ
dti-1332	28	26	its	its	PRON
dti-1332	28	27	pathogenesis	pathogenesis	NOUN
dti-1332	28	28	that	that	PRON
dti-1332	28	29	leads	lead	VERB
dti-1332	28	30	to	to	ADP
dti-1332	28	31	degeneration	degeneration	NOUN
dti-1332	28	32	of	of	ADP
dti-1332	28	33	cells	cell	NOUN
dti-1332	28	34	.	.	PUNCT
dti-1332	29	1	the	the	DET
dti-1332	29	2	upcoming	upcoming	ADJ
dti-1332	29	3	therapeutic	therapeutic	ADJ
dti-1332	29	4	developments	development	NOUN
dti-1332	29	5	using	use	VERB
dti-1332	29	6	rna	rna	NOUN
dti-1332	29	7	interference	interference	NOUN
dti-1332	29	8	technology	technology	NOUN
dti-1332	29	9	,	,	PUNCT
dti-1332	29	10	challenges	challenge	NOUN
dti-1332	29	11	faced	face	VERB
dti-1332	29	12	by	by	ADP
dti-1332	29	13	them	they	PRON
dti-1332	29	14	and	and	CCONJ
dti-1332	29	15	the	the	DET
dti-1332	29	16	promise	promise	NOUN
dti-1332	29	17	shown	show	VERB
dti-1332	29	18	by	by	ADP
dti-1332	29	19	recent	recent	ADJ
dti-1332	29	20	research	research	NOUN
dti-1332	29	21	in	in	ADP
dti-1332	29	22	developing	develop	VERB
dti-1332	29	23	nanomedicines	nanomedicine	NOUN
dti-1332	29	24	to	to	PART
dti-1332	29	25	combat	combat	VERB
dti-1332	29	26	such	such	ADJ
dti-1332	29	27	diseases	disease	NOUN
dti-1332	29	28	.	.	PUNCT
dti-1332	30	1	neurodegeneration	neurodegeneration	NOUN
dti-1332	30	2	—	—	PUNCT
dti-1332	30	3	spinocerebellar	spinocerebellar	ADJ
dti-1332	30	4	ataxia	ataxia	NOUN
dti-1332	30	5	neurodegenerative	neurodegenerative	ADJ
dti-1332	30	6	diseases	disease	NOUN
dti-1332	30	7	encompass	encompass	VERB
dti-1332	30	8	a	a	DET
dti-1332	30	9	separate	separate	ADJ
dti-1332	30	10	domain	domain	NOUN
dti-1332	30	11	among	among	ADP
dti-1332	30	12	neurological	neurological	ADJ
dti-1332	30	13	disorders	disorder	NOUN
dti-1332	30	14	and	and	CCONJ
dti-1332	30	15	are	be	AUX
dti-1332	30	16	specifi	specifi	PROPN
dti-1332	30	17	cally	cally	ADV
dti-1332	30	18	characterized	characterize	VERB
dti-1332	30	19	by	by	ADP
dti-1332	30	20	progressive	progressive	ADJ
dti-1332	30	21	loss	loss	NOUN
dti-1332	30	22	of	of	ADP
dti-1332	30	23	neurons	neuron	NOUN
dti-1332	30	24	as	as	ADV
dti-1332	30	25	well	well	ADV
dti-1332	30	26	as	as	ADP
dti-1332	30	27	their	their	PRON
dti-1332	30	28	structural	structural	ADJ
dti-1332	30	29	and	and	CCONJ
dti-1332	30	30	functional	functional	ADJ
dti-1332	30	31	degeneration	degeneration	NOUN
dti-1332	30	32	.	.	PUNCT
dti-1332	31	1	neurons	neuron	NOUN
dti-1332	31	2	having	have	VERB
dti-1332	31	3	their	their	PRON
dti-1332	31	4	primary	primary	ADJ
dti-1332	31	5	site	site	NOUN
dti-1332	31	6	in	in	ADP
dti-1332	31	7	brain	brain	NOUN
dti-1332	31	8	and	and	CCONJ
dti-1332	31	9	spinal	spinal	ADJ
dti-1332	31	10	cord	cord	NOUN
dti-1332	31	11	perform	perform	VERB
dti-1332	31	12	different	different	ADJ
dti-1332	31	13	functions	function	NOUN
dti-1332	31	14	like	like	ADP
dti-1332	31	15	processing	processing	NOUN
dti-1332	31	16	information	information	NOUN
dti-1332	31	17	,	,	PUNCT
dti-1332	31	18	making	make	VERB
dti-1332	31	19	decisions	decision	NOUN
dti-1332	31	20	and	and	CCONJ
dti-1332	31	21	controlling	control	VERB
dti-1332	31	22	voluntary	voluntary	ADJ
dti-1332	31	23	and	and	CCONJ
dti-1332	31	24	involuntary	involuntary	ADJ
dti-1332	31	25	functions	function	NOUN
dti-1332	31	26	of	of	ADP
dti-1332	31	27	the	the	DET
dti-1332	31	28	body	body	NOUN
dti-1332	31	29	.	.	PUNCT
dti-1332	32	1	neurodegeneration	neurodegeneration	NOUN
dti-1332	32	2	leads	lead	VERB
dti-1332	32	3	to	to	ADP
dti-1332	32	4	loss	loss	NOUN
dti-1332	32	5	of	of	ADP
dti-1332	32	6	mobility	mobility	NOUN
dti-1332	32	7	or	or	CCONJ
dti-1332	32	8	memory	memory	NOUN
dti-1332	32	9	depending	depend	VERB
dti-1332	32	10	on	on	ADP
dti-1332	32	11	which	which	DET
dti-1332	32	12	part	part	NOUN
dti-1332	32	13	of	of	ADP
dti-1332	32	14	the	the	DET
dti-1332	32	15	brain	brain	NOUN
dti-1332	32	16	it	it	PRON
dti-1332	32	17	affects	affect	VERB
dti-1332	32	18	.	.	PUNCT
dti-1332	33	1	therefore	therefore	ADV
dti-1332	33	2	,	,	PUNCT
dti-1332	33	3	any	any	DET
dti-1332	33	4	defect	defect	NOUN
dti-1332	33	5	in	in	ADP
dti-1332	33	6	any	any	DET
dti-1332	33	7	part	part	NOUN
dti-1332	33	8	of	of	ADP
dti-1332	33	9	the	the	DET
dti-1332	33	10	brain	brain	NOUN
dti-1332	33	11	can	can	AUX
dti-1332	33	12	affect	affect	VERB
dti-1332	33	13	a	a	DET
dti-1332	33	14	person	person	NOUN
dti-1332	33	15	emotionally	emotionally	ADV
dti-1332	33	16	,	,	PUNCT
dti-1332	33	17	psychologically	psychologically	ADV
dti-1332	33	18	and	and	CCONJ
dti-1332	33	19	physically	physically	ADV
dti-1332	33	20	.	.	PUNCT
dti-1332	34	1	the	the	DET
dti-1332	34	2	defect	defect	NOUN
dti-1332	34	3	can	can	AUX
dti-1332	34	4	have	have	VERB
dti-1332	34	5	many	many	ADJ
dti-1332	34	6	causes	cause	NOUN
dti-1332	34	7	starting	start	VERB
dti-1332	34	8	from	from	ADP
dti-1332	34	9	environmental	environmental	ADJ
dti-1332	34	10	to	to	ADP
dti-1332	34	11	genetical	genetical	NOUN
dti-1332	34	12	,	,	PUNCT
dti-1332	34	13	which	which	PRON
dti-1332	34	14	may	may	AUX
dti-1332	34	15	lead	lead	VERB
dti-1332	34	16	to	to	ADP
dti-1332	34	17	degeneration	degeneration	NOUN
dti-1332	34	18	of	of	ADP
dti-1332	34	19	the	the	DET
dti-1332	34	20	cells	cell	NOUN
dti-1332	34	21	in	in	ADP
dti-1332	34	22	brain	brain	NOUN
dti-1332	34	23	leading	lead	VERB
dti-1332	34	24	to	to	ADP
dti-1332	34	25	diseases	disease	NOUN
dti-1332	34	26	like	like	ADP
dti-1332	34	27	parkinson	parkinson	NOUN
dti-1332	34	28	’s	’s	PART
dti-1332	34	29	,	,	PUNCT
dti-1332	34	30	alzheimer	alzheimer	PROPN
dti-1332	34	31	’s	’s	PROPN
dti-1332	34	32	,	,	PUNCT
dti-1332	34	33	huntington	huntington	PROPN
dti-1332	34	34	’s	’s	PROPN
dti-1332	34	35	,	,	PUNCT
dti-1332	34	36	amyotrophic	amyotrophic	ADJ
dti-1332	34	37	lateral	lateral	ADJ
dti-1332	34	38	sclerosis	sclerosis	NOUN
dti-1332	34	39	and	and	CCONJ
dti-1332	34	40	spino	spino	PROPN
dti-1332	34	41	cerebellar	cerebellar	ADJ
dti-1332	34	42	degeneration	degeneration	NOUN
dti-1332	34	43	.	.	PUNCT
dti-1332	35	1	these	these	DET
dti-1332	35	2	diseases	disease	NOUN
dti-1332	35	3	tend	tend	VERB
dti-1332	35	4	to	to	PART
dti-1332	35	5	progress	progress	VERB
dti-1332	35	6	slowly	slowly	ADV
dti-1332	35	7	over	over	ADP
dti-1332	35	8	the	the	DET
dti-1332	35	9	time	time	NOUN
dti-1332	35	10	and	and	CCONJ
dti-1332	35	11	generally	generally	ADV
dti-1332	35	12	target	target	VERB
dti-1332	35	13	older	old	ADJ
dti-1332	35	14	population	population	NOUN
dti-1332	35	15	.	.	PUNCT
dti-1332	36	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	36	2	degeneration	degeneration	NOUN
dti-1332	36	3	(	(	PUNCT
dti-1332	36	4	scd	scd	NOUN
dti-1332	36	5	)	)	PUNCT
dti-1332	36	6	is	be	AUX
dti-1332	36	7	a	a	DET
dti-1332	36	8	neurodegenerative	neurodegenerative	ADJ
dti-1332	36	9	disease	disease	NOUN
dti-1332	36	10	involving	involve	VERB
dti-1332	36	11	loss	loss	NOUN
dti-1332	36	12	of	of	ADP
dti-1332	36	13	cells	cell	NOUN
dti-1332	36	14	in	in	ADP
dti-1332	36	15	cerebellum	cerebellum	NOUN
dti-1332	36	16	and	and	CCONJ
dti-1332	36	17	spinal	spinal	ADJ
dti-1332	36	18	cord	cord	NOUN
dti-1332	36	19	.	.	PUNCT
dti-1332	37	1	cells	cell	NOUN
dti-1332	37	2	in	in	ADP
dti-1332	37	3	the	the	DET
dti-1332	37	4	cerebellum	cerebellum	NOUN
dti-1332	37	5	are	be	AUX
dti-1332	37	6	associated	associate	VERB
dti-1332	37	7	with	with	ADP
dti-1332	37	8	regulation	regulation	NOUN
dti-1332	37	9	and	and	CCONJ
dti-1332	37	10	coordination	coordination	NOUN
dti-1332	37	11	of	of	ADP
dti-1332	37	12	movement	movement	NOUN
dti-1332	37	13	,	,	PUNCT
dti-1332	37	14	posture	posture	NOUN
dti-1332	37	15	and	and	CCONJ
dti-1332	37	16	balance	balance	NOUN
dti-1332	37	17	.	.	PUNCT
dti-1332	38	1	thus	thus	ADV
dti-1332	38	2	,	,	PUNCT
dti-1332	38	3	the	the	DET
dti-1332	38	4	disease	disease	NOUN
dti-1332	38	5	leads	lead	VERB
dti-1332	38	6	to	to	ADP
dti-1332	38	7	a	a	DET
dti-1332	38	8	state	state	NOUN
dti-1332	38	9	called	call	VERB
dti-1332	38	10	ataxia	ataxia	NOUN
dti-1332	38	11	,	,	PUNCT
dti-1332	38	12	typified	typify	VERB
dti-1332	38	13	by	by	ADP
dti-1332	38	14	damage	damage	NOUN
dti-1332	38	15	to	to	ADP
dti-1332	38	16	a	a	DET
dti-1332	38	17	part	part	NOUN
dti-1332	38	18	of	of	ADP
dti-1332	38	19	the	the	DET
dti-1332	38	20	brain	brain	NOUN
dti-1332	38	21	responsible	responsible	ADJ
dti-1332	38	22	for	for	ADP
dti-1332	38	23	movement	movement	NOUN
dti-1332	38	24	resulting	result	VERB
dti-1332	38	25	in	in	ADP
dti-1332	38	26	lumbering	lumber	VERB
dti-1332	38	27	,	,	PUNCT
dti-1332	38	28	unsteady	unsteady	ADJ
dti-1332	38	29	and	and	CCONJ
dti-1332	38	30	maladroit	maladroit	ADJ
dti-1332	38	31	motion	motion	NOUN
dti-1332	38	32	of	of	ADP
dti-1332	38	33	the	the	DET
dti-1332	38	34	body	body	NOUN
dti-1332	38	35	due	due	ADP
dti-1332	38	36	to	to	ADP
dti-1332	38	37	the	the	DET
dti-1332	38	38	failure	failure	NOUN
dti-1332	38	39	of	of	ADP
dti-1332	38	40	fine	fine	ADJ
dti-1332	38	41	coordination	coordination	NOUN
dti-1332	38	42	of	of	ADP
dti-1332	38	43	muscle	muscle	NOUN
dti-1332	38	44	movements	movement	NOUN
dti-1332	38	45	.	.	PUNCT
dti-1332	39	1	scd	scd	PROPN
dti-1332	39	2	was	be	AUX
dti-1332	39	3	fi	fi	NOUN
dti-1332	39	4	rst	rst	PROPN
dti-1332	39	5	categorized	categorize	VERB
dti-1332	39	6	by	by	ADP
dti-1332	39	7	holmes	holme	NOUN
dti-1332	39	8	based	base	VERB
dti-1332	39	9	on	on	ADP
dti-1332	39	10	neuropathogenicity	neuropathogenicity	NOUN
dti-1332	39	11	as	as	ADP
dti-1332	39	12	spinocerebellar	spinocerebellar	ADJ
dti-1332	39	13	degeneration	degeneration	NOUN
dti-1332	39	14	,	,	PUNCT
dti-1332	39	15	degeneration	degeneration	NOUN
dti-1332	39	16	of	of	ADP
dti-1332	39	17	cerebellar	cerebellar	ADJ
dti-1332	39	18	cortex	cortex	NOUN
dti-1332	39	19	and	and	CCONJ
dti-1332	39	20	olivopontocerebellar	olivopontocerebellar	ADJ
dti-1332	39	21	atrophy	atrophy	NOUN
dti-1332	39	22	.	.	PUNCT
dti-1332	40	1	later	later	ADV
dti-1332	40	2	harding	harding	PROPN
dti-1332	40	3	categorized	categorize	VERB
dti-1332	40	4	it	it	PRON
dti-1332	40	5	as	as	ADP
dti-1332	40	6	congenital	congenital	ADJ
dti-1332	40	7	,	,	PUNCT
dti-1332	40	8	hereditary	hereditary	ADJ
dti-1332	40	9	and	and	CCONJ
dti-1332	40	10	non	non	ADJ
dti-1332	40	11	-	-	ADJ
dti-1332	40	12	hereditary	hereditary	ADJ
dti-1332	40	13	on	on	ADP
dti-1332	40	14	clinical	clinical	ADJ
dti-1332	40	15	basis	basis	NOUN
dti-1332	40	16	,	,	PUNCT
dti-1332	40	17	which	which	PRON
dti-1332	40	18	is	be	AUX
dti-1332	40	19	now	now	ADV
dti-1332	40	20	widely	widely	ADV
dti-1332	40	21	accepted	accept	VERB
dti-1332	40	22	(	(	PUNCT
dti-1332	40	23	everett	everett	PROPN
dti-1332	40	24	et	et	PROPN
dti-1332	40	25	al	al	PROPN
dti-1332	40	26	.	.	PROPN
dti-1332	40	27	2004	2004	NUM
dti-1332	40	28	)	)	PUNCT
dti-1332	40	29	.	.	PUNCT
dti-1332	41	1	the	the	DET
dti-1332	41	2	genetic	genetic	ADJ
dti-1332	41	3	causes	cause	NOUN
dti-1332	41	4	like	like	ADP
dti-1332	41	5	autosomal	autosomal	ADJ
dti-1332	41	6	dominant	dominant	NOUN
dti-1332	41	7	,	,	PUNCT
dti-1332	41	8	autosomal	autosomal	ADJ
dti-1332	41	9	recessive	recessive	ADJ
dti-1332	41	10	,	,	PUNCT
dti-1332	41	11	x	x	X
dti-1332	41	12	-	-	VERB
dti-1332	41	13	linked	link	VERB
dti-1332	41	14	and	and	CCONJ
dti-1332	41	15	mitochondrial	mitochondrial	ADJ
dti-1332	41	16	defects	defect	NOUN
dti-1332	41	17	are	be	AUX
dti-1332	41	18	hereditary	hereditary	ADJ
dti-1332	41	19	in	in	ADP
dti-1332	41	20	nature	nature	NOUN
dti-1332	41	21	and	and	CCONJ
dti-1332	41	22	the	the	DET
dti-1332	41	23	non	non	ADJ
dti-1332	41	24	-	-	ADJ
dti-1332	41	25	genetic	genetic	ADJ
dti-1332	41	26	or	or	CCONJ
dti-1332	41	27	non	non	ADJ
dti-1332	41	28	-	-	ADJ
dti-1332	41	29	hereditary	hereditary	ADJ
dti-1332	41	30	causes	cause	NOUN
dti-1332	41	31	like	like	ADP
dti-1332	41	32	alcoholism	alcoholism	NOUN
dti-1332	41	33	,	,	PUNCT
dti-1332	41	34	vitamin	vitamin	NOUN
dti-1332	41	35	defi	defi	NOUN
dti-1332	41	36	ciency	ciency	NOUN
dti-1332	41	37	,	,	PUNCT
dti-1332	41	38	multiple	multiple	ADJ
dti-1332	41	39	sclerosis	sclerosis	NOUN
dti-1332	41	40	,	,	PUNCT
dti-1332	41	41	vascular	vascular	ADJ
dti-1332	41	42	disease	disease	NOUN
dti-1332	41	43	and	and	CCONJ
dti-1332	41	44	primary	primary	ADJ
dti-1332	41	45	or	or	CCONJ
dti-1332	41	46	metastatic	metastatic	ADJ
dti-1332	41	47	tumors	tumor	NOUN
dti-1332	41	48	,	,	PUNCT
dti-1332	41	49	lead	lead	VERB
dti-1332	41	50	to	to	ADP
dti-1332	41	51	the	the	DET
dti-1332	41	52	expression	expression	NOUN
dti-1332	41	53	of	of	ADP
dti-1332	41	54	pathogenic	pathogenic	ADJ
dti-1332	41	55	behavior	behavior	NOUN
dti-1332	41	56	of	of	ADP
dti-1332	41	57	the	the	DET
dti-1332	41	58	disease	disease	NOUN
dti-1332	41	59	.	.	PUNCT
dti-1332	42	1	the	the	DET
dti-1332	42	2	non	non	ADJ
dti-1332	42	3	-	-	ADJ
dti-1332	42	4	hereditary	hereditary	ADJ
dti-1332	42	5	group	group	NOUN
dti-1332	42	6	is	be	AUX
dti-1332	42	7	also	also	ADV
dti-1332	42	8	known	know	VERB
dti-1332	42	9	as	as	ADP
dti-1332	42	10	sporadic	sporadic	ADJ
dti-1332	42	11	or	or	CCONJ
dti-1332	42	12	acquired	acquire	VERB
dti-1332	42	13	ataxia	ataxia	NOUN
dti-1332	42	14	.	.	PUNCT
dti-1332	43	1	the	the	DET
dti-1332	43	2	autosomal	autosomal	ADJ
dti-1332	43	3	dominant	dominant	ADJ
dti-1332	43	4	cerebellar	cerebellar	ADJ
dti-1332	43	5	ataxia	ataxia	NOUN
dti-1332	43	6	(	(	PUNCT
dti-1332	43	7	adca	adca	NOUN
dti-1332	43	8	)	)	PUNCT
dti-1332	43	9	includes	include	VERB
dti-1332	43	10	a	a	DET
dti-1332	43	11	heterogenous	heterogenous	ADJ
dti-1332	43	12	group	group	NOUN
dti-1332	43	13	of	of	ADP
dti-1332	43	14	neurodegenerative	neurodegenerative	ADJ
dti-1332	43	15	disorders	disorder	NOUN
dti-1332	43	16	and	and	CCONJ
dti-1332	43	17	are	be	AUX
dti-1332	43	18	further	far	ADV
dti-1332	43	19	classifi	classifi	PROPN
dti-1332	43	20	ed	ed	PROPN
dti-1332	43	21	as	as	ADV
dti-1332	43	22	adca	adca	ADV
dti-1332	43	23	i	i	PRON
dti-1332	43	24	(	(	PUNCT
dti-1332	43	25	sca	sca	PROPN
dti-1332	43	26	1	1	NUM
dti-1332	43	27	,	,	PUNCT
dti-1332	43	28	2	2	NUM
dti-1332	43	29	,	,	PUNCT
dti-1332	43	30	3	3	NUM
dti-1332	43	31	,	,	PUNCT
dti-1332	43	32	4	4	NUM
dti-1332	43	33	,	,	PUNCT
dti-1332	43	34	6	6	NUM
dti-1332	43	35	,	,	PUNCT
dti-1332	43	36	8	8	NUM
dti-1332	43	37	,	,	PUNCT
dti-1332	43	38	12	12	NUM
dti-1332	43	39	,	,	PUNCT
dti-1332	43	40	13	13	NUM
dti-1332	43	41	,	,	PUNCT
dti-1332	43	42	16	16	NUM
dti-1332	43	43	)	)	PUNCT
dti-1332	43	44	,	,	PUNCT
dti-1332	43	45	adca	adca	PROPN
dti-1332	43	46	ii	ii	PROPN
dti-1332	43	47	(	(	PUNCT
dti-1332	43	48	sca7	sca7	PROPN
dti-1332	43	49	)	)	PUNCT
dti-1332	43	50	and	and	CCONJ
dti-1332	43	51	adca	adca	ADJ
dti-1332	43	52	iii	iii	X
dti-1332	43	53	(	(	PUNCT
dti-1332	43	54	sca	sca	PROPN
dti-1332	43	55	5	5	NUM
dti-1332	43	56	,	,	PUNCT
dti-1332	43	57	10	10	NUM
dti-1332	43	58	,	,	PUNCT
dti-1332	43	59	11	11	NUM
dti-1332	43	60	,	,	PUNCT
dti-1332	43	61	14	14	NUM
dti-1332	43	62	,	,	PUNCT
dti-1332	43	63	22	22	NUM
dti-1332	43	64	)	)	PUNCT
dti-1332	43	65	as	as	SCONJ
dti-1332	43	66	summarized	summarize	VERB
dti-1332	43	67	in	in	ADP
dti-1332	43	68	table	table	NOUN
dti-1332	43	69	1	1	NUM
dti-1332	43	70	.	.	PUNCT
dti-1332	44	1	the	the	DET
dti-1332	44	2	symptoms	symptom	NOUN
dti-1332	44	3	of	of	ADP
dti-1332	44	4	the	the	DET
dti-1332	44	5	condition	condition	NOUN
dti-1332	44	6	vary	vary	VERB
dti-1332	44	7	with	with	ADP
dti-1332	44	8	the	the	DET
dti-1332	44	9	specifi	specifi	PROPN
dti-1332	44	10	c	c	PROPN
dti-1332	44	11	type	type	NOUN
dti-1332	44	12	(	(	PUNCT
dti-1332	44	13	there	there	PRON
dti-1332	44	14	are	be	VERB
dti-1332	44	15	several	several	ADJ
dti-1332	44	16	)	)	PUNCT
dti-1332	44	17	,	,	PUNCT
dti-1332	44	18	and	and	CCONJ
dti-1332	44	19	with	with	ADP
dti-1332	44	20	the	the	DET
dti-1332	44	21	individual	individual	ADJ
dti-1332	44	22	patient	patient	NOUN
dti-1332	44	23	.	.	PUNCT
dti-1332	45	1	generally	generally	ADV
dti-1332	45	2	a	a	DET
dti-1332	45	3	sufferer	sufferer	NOUN
dti-1332	45	4	retains	retain	VERB
dti-1332	45	5	full	full	ADJ
dti-1332	45	6	mental	mental	ADJ
dti-1332	45	7	capacity	capacity	NOUN
dti-1332	45	8	while	while	SCONJ
dti-1332	45	9	they	they	PRON
dti-1332	45	10	progressively	progressively	ADV
dti-1332	45	11	lose	lose	VERB
dti-1332	45	12	physical	physical	ADJ
dti-1332	45	13	control	control	NOUN
dti-1332	45	14	over	over	ADP
dti-1332	45	15	their	their	PRON
dti-1332	45	16	body	body	NOUN
dti-1332	45	17	until	until	ADP
dti-1332	45	18	their	their	PRON
dti-1332	45	19	death	death	NOUN
dti-1332	45	20	.	.	PUNCT
dti-1332	46	1	in	in	ADP
dti-1332	46	2	the	the	DET
dti-1332	46	3	united	united	PROPN
dti-1332	46	4	states	states	PROPN
dti-1332	46	5	approximately	approximately	ADV
dti-1332	46	6	150,000	150,000	NUM
dti-1332	46	7	people	people	NOUN
dti-1332	46	8	alone	alone	ADV
dti-1332	46	9	are	be	AUX
dti-1332	46	10	affl	affl	NOUN
dti-1332	46	11	icted	icte	VERB
dti-1332	46	12	with	with	ADP
dti-1332	46	13	either	either	CCONJ
dti-1332	46	14	acquired	acquire	VERB
dti-1332	46	15	or	or	CCONJ
dti-1332	46	16	hereditary	hereditary	ADJ
dti-1332	46	17	form	form	NOUN
dti-1332	46	18	of	of	ADP
dti-1332	46	19	ataxia	ataxia	NOUN
dti-1332	46	20	.	.	PUNCT
dti-1332	47	1	autosomal	autosomal	ADJ
dti-1332	47	2	recessive	recessive	ADJ
dti-1332	47	3	—	—	PUNCT
dti-1332	47	4	friedreich	friedreich	NOUN
dti-1332	47	5	ataxia	ataxia	NOUN
dti-1332	47	6	occurs	occur	VERB
dti-1332	47	7	in	in	ADP
dti-1332	47	8	1	1	NUM
dti-1332	47	9	out	out	ADP
dti-1332	47	10	of	of	ADP
dti-1332	47	11	50,000	50,000	NUM
dti-1332	47	12	populations	population	NOUN
dti-1332	47	13	and	and	CCONJ
dti-1332	47	14	is	be	AUX
dti-1332	47	15	among	among	ADP
dti-1332	47	16	the	the	DET
dti-1332	47	17	most	most	ADV
dti-1332	47	18	common	common	ADJ
dti-1332	47	19	inherited	inherit	VERB
dti-1332	47	20	ataxia	ataxia	NOUN
dti-1332	47	21	.	.	PUNCT
dti-1332	48	1	complete	complete	ADJ
dti-1332	48	2	information	information	NOUN
dti-1332	48	3	on	on	ADP
dti-1332	48	4	ataxia	ataxia	NOUN
dti-1332	48	5	is	be	AUX
dti-1332	48	6	beyond	beyond	ADP
dti-1332	48	7	the	the	DET
dti-1332	48	8	scope	scope	NOUN
dti-1332	48	9	of	of	ADP
dti-1332	48	10	this	this	DET
dti-1332	48	11	review	review	NOUN
dti-1332	48	12	but	but	CCONJ
dti-1332	48	13	a	a	DET
dti-1332	48	14	good	good	ADJ
dti-1332	48	15	detail	detail	NOUN
dti-1332	48	16	on	on	ADP
dti-1332	48	17	different	different	ADJ
dti-1332	48	18	types	type	NOUN
dti-1332	48	19	of	of	ADP
dti-1332	48	20	autosomal	autosomal	ADJ
dti-1332	48	21	dominant/	dominant/	NUM
dti-1332	48	22	recessive	recessive	ADJ
dti-1332	48	23	cerebellar	cerebellar	ADJ
dti-1332	48	24	ataxia	ataxia	NOUN
dti-1332	48	25	,	,	PUNCT
dti-1332	48	26	x	x	VERB
dti-1332	48	27	-	-	VERB
dti-1332	48	28	linked	link	VERB
dti-1332	48	29	hereditary	hereditary	ADJ
dti-1332	48	30	ataxia	ataxia	NOUN
dti-1332	48	31	and	and	CCONJ
dti-1332	48	32	ataxias	ataxia	NOUN
dti-1332	48	33	with	with	ADP
dti-1332	48	34	mitochondrial	mitochondrial	ADJ
dti-1332	48	35	disorders	disorder	NOUN
dti-1332	48	36	has	have	AUX
dti-1332	48	37	been	be	AUX
dti-1332	48	38	reported	report	VERB
dti-1332	48	39	and	and	CCONJ
dti-1332	48	40	revised	revise	VERB
dti-1332	48	41	by	by	ADP
dti-1332	48	42	thomas	thomas	PROPN
dti-1332	48	43	d	d	PROPN
dti-1332	48	44	bird	bird	PROPN
dti-1332	48	45	(	(	PUNCT
dti-1332	48	46	bird	bird	NOUN
dti-1332	48	47	td	td	NOUN
dti-1332	48	48	,	,	PUNCT
dti-1332	48	49	2008	2008	NUM
dti-1332	48	50	)	)	PUNCT
dti-1332	48	51	.	.	PUNCT
dti-1332	49	1	autosomal	autosomal	ADJ
dti-1332	49	2	dominant	dominant	ADJ
dti-1332	49	3	cerebellar	cerebellar	ADJ
dti-1332	49	4	ataxia	ataxia	NOUN
dti-1332	49	5	as	as	SCONJ
dti-1332	49	6	summarized	summarize	VERB
dti-1332	49	7	in	in	ADP
dti-1332	49	8	table	table	NOUN
dti-1332	49	9	1	1	NUM
dti-1332	49	10	,	,	PUNCT
dti-1332	49	11	most	most	ADJ
dti-1332	49	12	of	of	ADP
dti-1332	49	13	the	the	DET
dti-1332	49	14	late	late	ADJ
dti-1332	49	15	onset	onset	NOUN
dti-1332	49	16	neurodegenerative	neurodegenerative	ADJ
dti-1332	49	17	diseases	disease	NOUN
dti-1332	49	18	are	be	AUX
dti-1332	49	19	caused	cause	VERB
dti-1332	49	20	by	by	ADP
dti-1332	49	21	protein	protein	NOUN
dti-1332	49	22	aggregation	aggregation	NOUN
dti-1332	49	23	and	and	CCONJ
dti-1332	49	24	are	be	AUX
dti-1332	49	25	known	know	VERB
dti-1332	49	26	as	as	ADP
dti-1332	49	27	proteinopathies	proteinopathie	NOUN
dti-1332	49	28	(	(	PUNCT
dti-1332	49	29	rubinsztein	rubinsztein	NOUN
dti-1332	49	30	,	,	PUNCT
dti-1332	49	31	2006	2006	NUM
dti-1332	49	32	)	)	PUNCT
dti-1332	49	33	.	.	PUNCT
dti-1332	50	1	these	these	DET
dti-1332	50	2	proteins	protein	NOUN
dti-1332	50	3	are	be	AUX
dti-1332	50	4	either	either	ADV
dti-1332	50	5	secreted	secrete	VERB
dti-1332	50	6	in	in	ADP
dti-1332	50	7	cytoplasm	cytoplasm	NOUN
dti-1332	50	8	or	or	CCONJ
dti-1332	50	9	nucleus	nucleus	NOUN
dti-1332	50	10	,	,	PUNCT
dti-1332	50	11	where	where	SCONJ
dti-1332	50	12	they	they	PRON
dti-1332	50	13	alter	alter	VERB
dti-1332	50	14	the	the	DET
dti-1332	50	15	neuronal	neuronal	ADJ
dti-1332	50	16	activities	activity	NOUN
dti-1332	50	17	related	relate	VERB
dti-1332	50	18	to	to	ADP
dti-1332	50	19	signaling	signal	VERB
dti-1332	50	20	pathways	pathway	NOUN
dti-1332	50	21	,	,	PUNCT
dti-1332	50	22	disintegrating	disintegrate	VERB
dti-1332	50	23	the	the	DET
dti-1332	50	24	neuronal	neuronal	ADJ
dti-1332	50	25	network	network	NOUN
dti-1332	50	26	(	(	PUNCT
dti-1332	50	27	palop	palop	NOUN
dti-1332	50	28	,	,	PUNCT
dti-1332	50	29	2006	2006	NUM
dti-1332	50	30	)	)	PUNCT
dti-1332	50	31	.	.	PUNCT
dti-1332	51	1	as	as	ADP
dti-1332	51	2	a	a	DET
dti-1332	51	3	consequence	consequence	NOUN
dti-1332	51	4	it	it	PRON
dti-1332	51	5	causes	cause	VERB
dti-1332	51	6	considerable	considerable	ADJ
dti-1332	51	7	toxicity	toxicity	NOUN
dti-1332	51	8	to	to	ADP
dti-1332	51	9	the	the	DET
dti-1332	51	10	cells	cell	NOUN
dti-1332	51	11	.	.	PUNCT
dti-1332	52	1	in	in	ADP
dti-1332	52	2	certain	certain	ADJ
dti-1332	52	3	cases	case	NOUN
dti-1332	52	4	even	even	ADV
dti-1332	52	5	genetic	genetic	ADJ
dti-1332	52	6	mutations	mutation	NOUN
dti-1332	52	7	may	may	AUX
dti-1332	52	8	lead	lead	VERB
dti-1332	52	9	to	to	ADP
dti-1332	52	10	rapid	rapid	ADJ
dti-1332	52	11	formation	formation	NOUN
dti-1332	52	12	of	of	ADP
dti-1332	52	13	fi	fi	NOUN
dti-1332	52	14	brillar	brillar	ADJ
dti-1332	52	15	protein	protein	NOUN
dti-1332	52	16	aggregates	aggregate	NOUN
dti-1332	52	17	than	than	ADP
dti-1332	52	18	wild	wild	ADJ
dti-1332	52	19	type	type	NOUN
dti-1332	52	20	(	(	PUNCT
dti-1332	52	21	chow	chow	NOUN
dti-1332	52	22	et	et	PROPN
dti-1332	52	23	al	al	PROPN
dti-1332	52	24	.	.	PROPN
dti-1332	52	25	2004	2004	NUM
dti-1332	52	26	)	)	PUNCT
dti-1332	52	27	.	.	PUNCT
dti-1332	53	1	in	in	ADP
dti-1332	53	2	the	the	DET
dti-1332	53	3	case	case	NOUN
dti-1332	53	4	of	of	ADP
dti-1332	53	5	scd	scd	PROPN
dti-1332	53	6	,	,	PUNCT
dti-1332	53	7	specifi	specifi	PROPN
dti-1332	53	8	cally	cally	ADV
dti-1332	53	9	sca1	sca1	PROPN
dti-1332	53	10	,	,	PUNCT
dti-1332	53	11	2	2	NUM
dti-1332	53	12	,	,	PUNCT
dti-1332	53	13	3	3	NUM
dti-1332	53	14	,	,	PUNCT
dti-1332	53	15	6	6	NUM
dti-1332	53	16	,	,	PUNCT
dti-1332	53	17	7	7	NUM
dti-1332	53	18	,	,	PUNCT
dti-1332	53	19	12	12	NUM
dti-1332	53	20	,	,	PUNCT
dti-1332	53	21	17	17	NUM
dti-1332	53	22	and	and	CCONJ
dti-1332	53	23	drpla	drpla	ADJ
dti-1332	53	24	,	,	PUNCT
dti-1332	53	25	the	the	DET
dti-1332	53	26	disease	disease	NOUN
dti-1332	53	27	is	be	AUX
dti-1332	53	28	caused	cause	VERB
dti-1332	53	29	due	due	ADP
dti-1332	53	30	to	to	ADP
dti-1332	53	31	the	the	DET
dti-1332	53	32	formation	formation	NOUN
dti-1332	53	33	of	of	ADP
dti-1332	53	34	intranuclear	intranuclear	NOUN
dti-1332	53	35	inclusion	inclusion	NOUN
dti-1332	53	36	bodies	body	NOUN
dti-1332	53	37	,	,	PUNCT
dti-1332	53	38	which	which	PRON
dti-1332	53	39	are	be	AUX
dti-1332	53	40	the	the	DET
dti-1332	53	41	aggregates	aggregate	NOUN
dti-1332	53	42	of	of	ADP
dti-1332	53	43	an	an	DET
dti-1332	53	44	abnormal	abnormal	ADJ
dti-1332	53	45	protein	protein	NOUN
dti-1332	53	46	formed	form	VERB
dti-1332	53	47	from	from	ADP
dti-1332	53	48	an	an	DET
dti-1332	53	49	unstable	unstable	ADJ
dti-1332	53	50	expanded	expand	VERB
dti-1332	53	51	cag	cag	PROPN
dti-1332	53	52	trinucleotide	trinucleotide	ADP
dti-1332	53	53	repeat	repeat	NOUN
dti-1332	53	54	forming	form	VERB
dti-1332	53	55	a	a	DET
dti-1332	53	56	poly	poly	ADJ
dti-1332	53	57	glutamine	glutamine	NOUN
dti-1332	53	58	tract	tract	NOUN
dti-1332	53	59	(	(	PUNCT
dti-1332	53	60	zoghbi	zoghbi	NOUN
dti-1332	53	61	and	and	CCONJ
dti-1332	53	62	orr	orr	PROPN
dti-1332	53	63	,	,	PUNCT
dti-1332	53	64	2000	2000	NUM
dti-1332	53	65	)	)	PUNCT
dti-1332	53	66	.	.	PUNCT
dti-1332	54	1	the	the	DET
dti-1332	54	2	severity	severity	NOUN
dti-1332	54	3	and	and	CCONJ
dti-1332	54	4	the	the	DET
dti-1332	54	5	onset	onset	NOUN
dti-1332	54	6	of	of	ADP
dti-1332	54	7	disease	disease	NOUN
dti-1332	54	8	depend	depend	VERB
dti-1332	54	9	on	on	ADP
dti-1332	54	10	the	the	DET
dti-1332	54	11	length	length	NOUN
dti-1332	54	12	of	of	ADP
dti-1332	54	13	cag	cag	PROPN
dti-1332	54	14	repeat	repeat	VERB
dti-1332	54	15	;	;	PUNCT
dti-1332	54	16	that	that	PRON
dti-1332	54	17	is	be	AUX
dti-1332	54	18	,	,	PUNCT
dti-1332	54	19	longer	long	ADV
dti-1332	54	20	the	the	DET
dti-1332	54	21	length	length	NOUN
dti-1332	54	22	earlier	early	ADV
dti-1332	54	23	will	will	AUX
dti-1332	54	24	be	be	AUX
dti-1332	54	25	the	the	DET
dti-1332	54	26	onset	onset	NOUN
dti-1332	54	27	(	(	PUNCT
dti-1332	54	28	duenas	duena	NOUN
dti-1332	54	29	et	et	PROPN
dti-1332	54	30	al	al	PROPN
dti-1332	54	31	.	.	PROPN
dti-1332	54	32	2006	2006	NUM
dti-1332	54	33	)	)	PUNCT
dti-1332	54	34	.	.	PUNCT
dti-1332	55	1	autosomal	autosomal	ADJ
dti-1332	55	2	dominant	dominant	ADJ
dti-1332	55	3	cerebellar	cerebellar	ADJ
dti-1332	55	4	ataxia	ataxia	NOUN
dti-1332	55	5	normally	normally	ADV
dti-1332	55	6	sets	set	VERB
dti-1332	55	7	in	in	ADP
dti-1332	55	8	after	after	SCONJ
dti-1332	55	9	the	the	DET
dti-1332	55	10	person	person	NOUN
dti-1332	55	11	attain	attain	VERB
dti-1332	55	12	101	101	NUM
dti-1332	55	13	recent	recent	ADJ
dti-1332	55	14	advancements	advancement	NOUN
dti-1332	55	15	in	in	ADP
dti-1332	55	16	targeted	target	VERB
dti-1332	55	17	delivery	delivery	NOUN
dti-1332	55	18	of	of	ADP
dti-1332	55	19	therapeutic	therapeutic	ADJ
dti-1332	55	20	molecules	molecule	NOUN
dti-1332	55	21	drug	drug	NOUN
dti-1332	55	22	target	target	NOUN
dti-1332	55	23	insights	insight	NOUN
dti-1332	55	24	2008:3	2008:3	NUM
dti-1332	55	25	table1	table1	PROPN
dti-1332	55	26	.	.	PUNCT
dti-1332	56	1	different	different	ADJ
dti-1332	56	2	isoforms	isoform	NOUN
dti-1332	56	3	of	of	ADP
dti-1332	56	4	autosomal	autosomal	ADJ
dti-1332	56	5	dominant	dominant	ADJ
dti-1332	56	6	cerebellar	cerebellar	ADJ
dti-1332	56	7	ataxia	ataxia	NOUN
dti-1332	56	8	.	.	PUNCT
dti-1332	57	1	sca	sca	PROPN
dti-1332	57	2	subtype	subtype	NOUN
dti-1332	57	3	chromosome	chromosome	NOUN
dti-1332	57	4	locus	locus	NOUN
dti-1332	57	5	protein	protein	NOUN
dti-1332	57	6	name	name	NOUN
dti-1332	57	7	age	age	NOUN
dti-1332	57	8	onset	onset	NOUN
dti-1332	57	9	mutation	mutation	NOUN
dti-1332	57	10	symptoms	symptom	NOUN
dti-1332	57	11	references	reference	VERB
dti-1332	57	12	sca	sca	PROPN
dti-1332	57	13	1/	1/	NUM
dti-1332	57	14	spinocerebellar	spinocerebellar	ADJ
dti-1332	57	15	atrophy	atrophy	NOUN
dti-1332	57	16	i	i	NOUN
dti-1332	57	17	/	/	SYM
dti-1332	57	18	olivopontocerebellar	olivopontocerebellar	ADJ
dti-1332	57	19	atrophy	atrophy	NOUN
dti-1332	57	20	i	i	PRON
dti-1332	57	21	6p23	6p23	NOUN
dti-1332	57	22	ataxin	ataxin	NOUN
dti-1332	57	23	1	1	NUM
dti-1332	57	24	30	30	NUM
dti-1332	57	25	cag	cag	PROPN
dti-1332	57	26	repeat	repeat	VERB
dti-1332	57	27	eye	eye	NOUN
dti-1332	57	28	-	-	PUNCT
dti-1332	57	29	muscle	muscle	NOUN
dti-1332	57	30	dysfunction	dysfunction	NOUN
dti-1332	57	31	,	,	PUNCT
dti-1332	57	32	increased	increase	VERB
dti-1332	57	33	tendon	tendon	NOUN
dti-1332	57	34	refl	refl	PROPN
dti-1332	57	35	exes	ex	NOUN
dti-1332	58	1	david	david	PROPN
dti-1332	58	2	c	c	PROPN
dti-1332	58	3	et	et	PROPN
dti-1332	58	4	al	al	PROPN
dti-1332	58	5	.	.	PROPN
dti-1332	58	6	1995	1995	NUM
dti-1332	58	7	sca	sca	PROPN
dti-1332	58	8	2	2	NUM
dti-1332	58	9	:	:	PUNCT
dti-1332	58	10	episodic	episodic	ADJ
dti-1332	58	11	ataxia	ataxia	NOUN
dti-1332	58	12	type	type	NOUN
dti-1332	58	13	1	1	NUM
dti-1332	58	14	(	(	PUNCT
dti-1332	58	15	ea1	ea1	NOUN
dti-1332	58	16	)	)	PUNCT
dti-1332	58	17	and	and	CCONJ
dti-1332	58	18	episodic	episodic	ADJ
dti-1332	58	19	ataxia	ataxia	NOUN
dti-1332	58	20	type	type	NOUN
dti-1332	58	21	2	2	NUM
dti-1332	58	22	(	(	PUNCT
dti-1332	58	23	ea2	ea2	PROPN
dti-1332	58	24	)	)	PUNCT
dti-1332	58	25	12q24	12q24	NUM
dti-1332	58	26	ataxin	ataxin	NOUN
dti-1332	58	27	2	2	NUM
dti-1332	58	28	5–6	5–6	NOUN
dti-1332	58	29	cag	cag	PROPN
dti-1332	58	30	repeat	repeat	NOUN
dti-1332	58	31	tremors	tremor	NOUN
dti-1332	58	32	,	,	PUNCT
dti-1332	58	33	muscle	muscle	NOUN
dti-1332	58	34	spasms	spasm	NOUN
dti-1332	58	35	,	,	PUNCT
dti-1332	58	36	pons	pon	NOUN
dti-1332	58	37	atrophy	atrophy	NOUN
dti-1332	58	38	,	,	PUNCT
dti-1332	58	39	slowing	slow	VERB
dti-1332	58	40	of	of	ADP
dti-1332	58	41	eye	eye	NOUN
dti-1332	58	42	movement	movement	NOUN
dti-1332	58	43	cancel	cancel	VERB
dti-1332	58	44	g	g	PROPN
dti-1332	58	45	et	et	PROPN
dti-1332	58	46	al	al	PROPN
dti-1332	58	47	.	.	PROPN
dti-1332	59	1	1997	1997	NUM
dti-1332	59	2	sca	sca	NOUN
dti-1332	59	3	3	3	NUM
dti-1332	59	4	/	/	SYM
dti-1332	59	5	machado	machado	PROPN
dti-1332	59	6	joseph	joseph	PROPN
dti-1332	59	7	disease	disease	PROPN
dti-1332	59	8	14q24.3	14q24.3	NUM
dti-1332	59	9	-	-	PUNCT
dti-1332	59	10	q31	q31	ADJ
dti-1332	59	11	ataxin	ataxin	NOUN
dti-1332	59	12	3	3	NUM
dti-1332	59	13	10	10	NUM
dti-1332	59	14	cag	cag	PROPN
dti-1332	59	15	repeat	repeat	NOUN
dti-1332	59	16	dystonia	dystonia	NOUN
dti-1332	59	17	(	(	PUNCT
dti-1332	59	18	involuntary	involuntary	ADJ
dti-1332	59	19	and	and	CCONJ
dti-1332	59	20	repetitive	repetitive	ADJ
dti-1332	59	21	movements	movement	NOUN
dti-1332	59	22	)	)	PUNCT
dti-1332	59	23	,	,	PUNCT
dti-1332	59	24	unstable	unstable	ADJ
dti-1332	59	25	walking	walking	NOUN
dti-1332	59	26	or	or	CCONJ
dti-1332	59	27	standing	standing	NOUN
dti-1332	59	28	,	,	PUNCT
dti-1332	59	29	abnormal	abnormal	ADJ
dti-1332	59	30	hand	hand	NOUN
dti-1332	59	31	movements	movement	NOUN
dti-1332	59	32	,	,	PUNCT
dti-1332	59	33	nystagmus	nystagmus	NOUN
dti-1332	59	34	(	(	PUNCT
dti-1332	59	35	abnormal	abnormal	ADJ
dti-1332	59	36	eye	eye	NOUN
dti-1332	59	37	movement	movement	NOUN
dti-1332	59	38	)	)	PUNCT
dti-1332	59	39	durr	durr	NOUN
dti-1332	59	40	a	a	PRON
dti-1332	59	41	et	et	NOUN
dti-1332	59	42	al	al	PROPN
dti-1332	59	43	.	.	PROPN
dti-1332	59	44	1996	1996	NUM
dti-1332	59	45	;	;	PUNCT
dti-1332	59	46	haberhausena	haberhausena	PROPN
dti-1332	59	47	g	g	PROPN
dti-1332	59	48	et	et	PROPN
dti-1332	59	49	al	al	PROPN
dti-1332	59	50	.	.	PROPN
dti-1332	59	51	1995	1995	NUM
dti-1332	59	52	sca	sca	PROPN
dti-1332	59	53	4	4	NUM
dti-1332	59	54	:	:	PUNCT
dti-1332	59	55	type	type	NOUN
dti-1332	59	56	i	i	PRON
dti-1332	59	57	and	and	CCONJ
dti-1332	59	58	type	type	PROPN
dti-1332	59	59	iii	iii	PROPN
dti-1332	59	60	16q22.1	16q22.1	PROPN
dti-1332	59	61	unknown	unknown	ADJ
dti-1332	59	62	19–59/	19–59/	NUM
dti-1332	59	63	45–72	45–72	NUM
dti-1332	59	64	unknown	unknown	ADJ
dti-1332	59	65	sensory	sensory	ADJ
dti-1332	59	66	abnormalities	abnormality	NOUN
dti-1332	59	67	,	,	PUNCT
dti-1332	59	68	diffi	diffi	PROPN
dti-1332	59	69	culty	culty	PROPN
dti-1332	59	70	walking	walking	NOUN
dti-1332	59	71	,	,	PUNCT
dti-1332	59	72	loss	loss	NOUN
dti-1332	59	73	of	of	ADP
dti-1332	59	74	muscle	muscle	NOUN
dti-1332	59	75	control	control	NOUN
dti-1332	59	76	,	,	PUNCT
dti-1332	59	77	crippling	crippling	ADJ
dti-1332	59	78	condition	condition	NOUN
dti-1332	59	79	,	,	PUNCT
dti-1332	59	80	absence	absence	NOUN
dti-1332	59	81	of	of	ADP
dti-1332	59	82	tendon	tendon	PROPN
dti-1332	59	83	refl	refl	PROPN
dti-1332	59	84	exes	exes	PROPN
dti-1332	59	85	flanigan	flanigan	PROPN
dti-1332	59	86	k	k	PROPN
dti-1332	59	87	et	et	PROPN
dti-1332	59	88	al	al	PROPN
dti-1332	59	89	.	.	PROPN
dti-1332	59	90	1996	1996	NUM
dti-1332	59	91	;	;	PUNCT
dti-1332	59	92	hellenbroich	hellenbroich	PROPN
dti-1332	59	93	y	y	PROPN
dti-1332	59	94	et	et	PROPN
dti-1332	59	95	al	al	PROPN
dti-1332	59	96	.	.	PROPN
dti-1332	59	97	2003	2003	NUM
dti-1332	59	98	sca	sca	NOUN
dti-1332	59	99	5	5	NUM
dti-1332	59	100	11p13	11p13	NUM
dti-1332	59	101	beta	beta	NOUN
dti-1332	59	102	—	—	PUNCT
dti-1332	59	103	iii	iii	NUM
dti-1332	59	104	spectrin	spectrin	NOUN
dti-1332	59	105	10–68	10–68	NUM
dti-1332	59	106	deletion	deletion	NOUN
dti-1332	59	107	,	,	PUNCT
dti-1332	59	108	missense	missense	NOUN
dti-1332	59	109	mutation	mutation	NOUN
dti-1332	59	110	mild	mild	ADJ
dti-1332	59	111	ataxia	ataxia	NOUN
dti-1332	59	112	,	,	PUNCT
dti-1332	59	113	speech	speech	NOUN
dti-1332	59	114	disorders	disorder	NOUN
dti-1332	59	115	ranum	ranum	ADJ
dti-1332	59	116	lp	lp	INTJ
dti-1332	59	117	et	et	PROPN
dti-1332	59	118	al	al	PROPN
dti-1332	59	119	.	.	PROPN
dti-1332	59	120	1994	1994	NUM
dti-1332	59	121	;	;	PUNCT
dti-1332	59	122	ikeda	ikeda	PROPN
dti-1332	59	123	et	et	PROPN
dti-1332	59	124	al	al	PROPN
dti-1332	59	125	.	.	PROPN
dti-1332	59	126	2006	2006	NUM
dti-1332	59	127	sca	sca	NOUN
dti-1332	59	128	6	6	NUM
dti-1332	59	129	19p13	19p13	NUM
dti-1332	59	130	voltagedependent	voltagedependent	NOUN
dti-1332	59	131	p	p	X
dti-1332	59	132	/	/	SYM
dti-1332	59	133	q	q	ADJ
dti-1332	59	134	-	-	PUNCT
dti-1332	59	135	type	type	NOUN
dti-1332	59	136	calcium	calcium	NOUN
dti-1332	59	137	channel	channel	NOUN
dti-1332	59	138	alpha-1a	alpha-1a	DET
dti-1332	59	139	subunit	subunit	NOUN
dti-1332	59	140	19–71	19–71	PROPN
dti-1332	59	141	cag	cag	PROPN
dti-1332	59	142	repeat	repeat	NOUN
dti-1332	59	143	limb	limb	NOUN
dti-1332	59	144	and	and	CCONJ
dti-1332	59	145	gait	gait	ADJ
dti-1332	59	146	ataxia	ataxia	NOUN
dti-1332	59	147	,	,	PUNCT
dti-1332	59	148	periodic	periodic	ADJ
dti-1332	59	149	episodes	episode	NOUN
dti-1332	59	150	of	of	ADP
dti-1332	59	151	paralysis	paralysis	NOUN
dti-1332	59	152	on	on	ADP
dti-1332	59	153	one	one	NUM
dti-1332	59	154	side	side	NOUN
dti-1332	59	155	of	of	ADP
dti-1332	59	156	the	the	DET
dti-1332	59	157	body	body	NOUN
dti-1332	59	158	,	,	PUNCT
dti-1332	59	159	speech	speech	NOUN
dti-1332	59	160	diffi	diffi	PROPN
dti-1332	59	161	culty	culty	NOUN
dti-1332	59	162	and	and	CCONJ
dti-1332	59	163	abnormal	abnormal	ADJ
dti-1332	59	164	eye	eye	NOUN
dti-1332	59	165	movement	movement	NOUN
dti-1332	59	166	zhuchenko	zhuchenko	ADJ
dti-1332	59	167	o	o	NOUN
dti-1332	59	168	et	et	PROPN
dti-1332	59	169	al	al	PROPN
dti-1332	59	170	.	.	PROPN
dti-1332	59	171	1997	1997	NUM
dti-1332	59	172	;	;	PUNCT
dti-1332	59	173	riess	riess	PROPN
dti-1332	59	174	o	o	INTJ
dti-1332	59	175	et	et	PROPN
dti-1332	59	176	al	al	PROPN
dti-1332	59	177	.	.	PROPN
dti-1332	59	178	1997	1997	NUM
dti-1332	59	179	;	;	PUNCT
dti-1332	59	180	matsuyama	matsuyama	PROPN
dti-1332	59	181	z	z	PROPN
dti-1332	59	182	et	et	PROPN
dti-1332	59	183	al	al	PROPN
dti-1332	59	184	.	.	PROPN
dti-1332	59	185	1997	1997	NUM
dti-1332	59	186	sca	sca	NOUN
dti-1332	60	1	7/	7/	NUM
dti-1332	60	2	olivopontocerebellar	olivopontocerebellar	ADJ
dti-1332	60	3	atrophy	atrophy	NOUN
dti-1332	60	4	iii	iii	NOUN
dti-1332	60	5	3p21.1	3p21.1	NOUN
dti-1332	60	6	-	-	PUNCT
dti-1332	60	7	p12	p12	ADJ
dti-1332	60	8	ataxin7	ataxin7	PROPN
dti-1332	60	9	0.5–60	0.5–60	PROPN
dti-1332	60	10	cag	cag	AUX
dti-1332	60	11	repeat	repeat	VERB
dti-1332	60	12	severe	severe	ADJ
dti-1332	60	13	eye	eye	NOUN
dti-1332	60	14	problems	problem	NOUN
dti-1332	60	15	(	(	PUNCT
dti-1332	60	16	retinal	retinal	ADJ
dti-1332	60	17	and	and	CCONJ
dti-1332	60	18	macular	macular	ADJ
dti-1332	60	19	degeneration	degeneration	NOUN
dti-1332	60	20	)	)	PUNCT
dti-1332	60	21	,	,	PUNCT
dti-1332	60	22	early	early	ADJ
dti-1332	60	23	blue	blue	ADJ
dti-1332	60	24	-	-	PUNCT
dti-1332	60	25	yellow	yellow	ADJ
dti-1332	60	26	color	color	NOUN
dti-1332	60	27	blindness	blindness	NOUN
dti-1332	60	28	,	,	PUNCT
dti-1332	60	29	hearing	hear	VERB
dti-1332	60	30	loss	loss	NOUN
dti-1332	60	31	,	,	PUNCT
dti-1332	60	32	heart	heart	NOUN
dti-1332	60	33	failure	failure	NOUN
dti-1332	60	34	,	,	PUNCT
dti-1332	60	35	liver	liver	NOUN
dti-1332	60	36	disorders	disorder	NOUN
dti-1332	60	37	,	,	PUNCT
dti-1332	60	38	muscle	muscle	NOUN
dti-1332	60	39	loss	loss	NOUN
dti-1332	60	40	,	,	PUNCT
dti-1332	60	41	developmental	developmental	ADJ
dti-1332	60	42	delays	delay	NOUN
dti-1332	60	43	david	david	PROPN
dti-1332	60	44	g	g	PROPN
dti-1332	60	45	et	et	PROPN
dti-1332	60	46	al	al	PROPN
dti-1332	60	47	.	.	PROPN
dti-1332	60	48	1996	1996	NUM
dti-1332	60	49	;	;	PUNCT
dti-1332	60	50	david	david	PROPN
dti-1332	60	51	g	g	PROPN
dti-1332	60	52	et	et	PROPN
dti-1332	60	53	al	al	PROPN
dti-1332	60	54	.	.	PROPN
dti-1332	60	55	1997	1997	NUM
dti-1332	60	56	sca8	sca8	PROPN
dti-1332	60	57	13q21	13q21	NUM
dti-1332	60	58	kelch	kelch	PROPN
dti-1332	60	59	-	-	PUNCT
dti-1332	60	60	like	like	ADJ
dti-1332	60	61	i	i	PRON
dti-1332	60	62	39	39	NUM
dti-1332	60	63	ctg	ctg	NOUN
dti-1332	60	64	repeat	repeat	NOUN
dti-1332	60	65	horizontal	horizontal	ADJ
dti-1332	60	66	nystagmus	nystagmus	NOUN
dti-1332	60	67	(	(	PUNCT
dti-1332	60	68	a	a	DET
dti-1332	60	69	rapid	rapid	ADJ
dti-1332	60	70	,	,	PUNCT
dti-1332	60	71	involuntary	involuntary	ADJ
dti-1332	60	72	,	,	PUNCT
dti-1332	60	73	oscillatory	oscillatory	ADJ
dti-1332	60	74	motion	motion	NOUN
dti-1332	60	75	of	of	ADP
dti-1332	60	76	the	the	DET
dti-1332	60	77	eyeball	eyeball	NOUN
dti-1332	60	78	)	)	PUNCT
dti-1332	60	79	,	,	PUNCT
dti-1332	60	80	decreased	decrease	VERB
dti-1332	60	81	vibration	vibration	NOUN
dti-1332	60	82	sense	sense	NOUN
dti-1332	60	83	;	;	PUNCT
dti-1332	60	84	rarely	rarely	ADV
dti-1332	60	85	,	,	PUNCT
dti-1332	60	86	cognitive	cognitive	ADJ
dti-1332	60	87	impairment	impairment	NOUN
dti-1332	60	88	koob	koob	NOUN
dti-1332	60	89	ml	ml	PROPN
dti-1332	60	90	et	et	PROPN
dti-1332	60	91	al	al	PROPN
dti-1332	60	92	.	.	PROPN
dti-1332	60	93	1999	1999	NUM
dti-1332	60	94	;	;	PUNCT
dti-1332	60	95	day	day	NOUN
dti-1332	60	96	et	et	PROPN
dti-1332	60	97	al	al	PROPN
dti-1332	60	98	.	.	PROPN
dti-1332	60	99	2000	2000	NUM
dti-1332	60	100	;	;	PUNCT
dti-1332	60	101	juvonen	juvonen	PROPN
dti-1332	60	102	et	et	PROPN
dti-1332	60	103	al	al	PROPN
dti-1332	60	104	.	.	PROPN
dti-1332	60	105	2000	2000	NUM
dti-1332	60	106	;	;	PUNCT
dti-1332	60	107	ito	ito	PROPN
dti-1332	60	108	et	et	PROPN
dti-1332	60	109	al	al	PROPN
dti-1332	60	110	.	.	PROPN
dti-1332	60	111	2006	2006	NUM
dti-1332	60	112	(	(	PUNCT
dti-1332	60	113	continued	continue	VERB
dti-1332	60	114	)	)	PUNCT
dti-1332	60	115	102	102	NUM
dti-1332	60	116	prakash	prakash	PROPN
dti-1332	60	117	and	and	CCONJ
dti-1332	60	118	malhotra	malhotra	PROPN
dti-1332	60	119	drug	drug	PROPN
dti-1332	60	120	target	target	NOUN
dti-1332	60	121	insights	insight	NOUN
dti-1332	60	122	2008:3	2008:3	NUM
dti-1332	60	123	table1	table1	PROPN
dti-1332	60	124	.	.	PUNCT
dti-1332	61	1	(	(	PUNCT
dti-1332	61	2	continued	continue	VERB
dti-1332	61	3	)	)	PUNCT
dti-1332	61	4	.	.	PUNCT
dti-1332	62	1	sca	sca	PROPN
dti-1332	62	2	subtype	subtype	NOUN
dti-1332	62	3	chromosome	chromosome	NOUN
dti-1332	62	4	locus	locus	NOUN
dti-1332	62	5	protein	protein	NOUN
dti-1332	62	6	name	name	NOUN
dti-1332	62	7	age	age	NOUN
dti-1332	62	8	onset	onset	NOUN
dti-1332	62	9	mutation	mutation	NOUN
dti-1332	62	10	symptoms	symptom	NOUN
dti-1332	62	11	references	reference	VERB
dti-1332	62	12	sca	sca	PROPN
dti-1332	62	13	10	10	NUM
dti-1332	62	14	22q13	22q13	NUM
dti-1332	62	15	ataxin	ataxin	NOUN
dti-1332	62	16	10	10	NUM
dti-1332	62	17	36	36	NUM
dti-1332	62	18	attct	attct	NOUN
dti-1332	62	19	repeat	repeat	NOUN
dti-1332	62	20	motor	motor	NOUN
dti-1332	62	21	seizures	seizure	NOUN
dti-1332	62	22	,	,	PUNCT
dti-1332	62	23	irregular	irregular	ADJ
dti-1332	62	24	eye	eye	NOUN
dti-1332	62	25	movement	movement	NOUN
dti-1332	62	26	,	,	PUNCT
dti-1332	62	27	gait	gait	NOUN
dti-1332	62	28	and	and	CCONJ
dti-1332	62	29	limb	limb	NOUN
dti-1332	62	30	ataxia	ataxia	NOUN
dti-1332	62	31	,	,	PUNCT
dti-1332	62	32	speech	speech	NOUN
dti-1332	62	33	diffi	diffi	NOUN
dti-1332	62	34	culties	cultie	NOUN
dti-1332	62	35	zu	zu	NOUN
dti-1332	62	36	l	l	NOUN
dti-1332	62	37	et	et	PROPN
dti-1332	62	38	al	al	PROPN
dti-1332	62	39	.	.	PROPN
dti-1332	62	40	1999	1999	NUM
dti-1332	62	41	;	;	PUNCT
dti-1332	62	42	lin	lin	PROPN
dti-1332	62	43	x	x	PROPN
dti-1332	62	44	et	et	PROPN
dti-1332	62	45	al	al	PROPN
dti-1332	62	46	.	.	PROPN
dti-1332	62	47	2005	2005	NUM
dti-1332	62	48	;	;	PUNCT
dti-1332	62	49	grewal	grewal	PROPN
dti-1332	62	50	rp	rp	PROPN
dti-1332	62	51	et	et	PROPN
dti-1332	62	52	al	al	PROPN
dti-1332	62	53	.	.	PROPN
dti-1332	62	54	2002	2002	NUM
dti-1332	63	1	sca	sca	PROPN
dti-1332	63	2	11	11	NUM
dti-1332	63	3	15q14	15q14	NUM
dti-1332	63	4	-	-	PUNCT
dti-1332	63	5	q15.3	q15.3	NOUN
dti-1332	63	6	tautubulin	tautubulin	PROPN
dti-1332	63	7	kinase	kinase	PROPN
dti-1332	63	8	2	2	NUM
dti-1332	63	9	30	30	NUM
dti-1332	63	10	nonrepeat	nonrepeat	ADJ
dti-1332	63	11	mutations	mutation	NOUN
dti-1332	63	12	gait	gait	NOUN
dti-1332	63	13	disorders	disorder	NOUN
dti-1332	63	14	,	,	PUNCT
dti-1332	63	15	increased	increase	VERB
dti-1332	63	16	refl	refl	PROPN
dti-1332	63	17	ex	ex	PROPN
dti-1332	63	18	action	action	NOUN
dti-1332	63	19	,	,	PUNCT
dti-1332	63	20	eye	eye	NOUN
dti-1332	63	21	disturbances	disturbance	NOUN
dti-1332	63	22	,	,	PUNCT
dti-1332	63	23	irregular	irregular	ADJ
dti-1332	63	24	movements	movement	NOUN
dti-1332	63	25	and	and	CCONJ
dti-1332	63	26	speech	speech	NOUN
dti-1332	63	27	diffi	diffi	NOUN
dti-1332	63	28	culties	cultie	NOUN
dti-1332	63	29	worth	worth	ADJ
dti-1332	63	30	pf	pf	PROPN
dti-1332	63	31	et	et	PROPN
dti-1332	63	32	al	al	PROPN
dti-1332	63	33	.	.	PROPN
dti-1332	63	34	1999	1999	NUM
dti-1332	63	35	;	;	PUNCT
dti-1332	63	36	houlden	houlden	PROPN
dti-1332	63	37	et	et	PROPN
dti-1332	63	38	al	al	PROPN
dti-1332	63	39	.	.	PROPN
dti-1332	63	40	2007	2007	NUM
dti-1332	64	1	sca	sca	NOUN
dti-1332	64	2	12	12	NUM
dti-1332	64	3	5q31	5q31	NUM
dti-1332	64	4	-	-	PUNCT
dti-1332	64	5	q33	q33	NOUN
dti-1332	64	6	serine/	serine/	NUM
dti-1332	64	7	threonine	threonine	ADJ
dti-1332	64	8	protein	protein	NOUN
dti-1332	64	9	phosphatase	phosphatase	NOUN
dti-1332	64	10	2a	2a	NUM
dti-1332	64	11	55	55	NUM
dti-1332	64	12	-	-	PUNCT
dti-1332	64	13	kd	kd	NOUN
dti-1332	64	14	regulatory	regulatory	ADJ
dti-1332	64	15	subunit	subunit	NOUN
dti-1332	64	16	b	b	PROPN
dti-1332	64	17	beta	beta	ADJ
dti-1332	64	18	isoform	isoform	NOUN
dti-1332	64	19	33	33	NUM
dti-1332	64	20	cag	cag	PROPN
dti-1332	64	21	repeat	repeat	NOUN
dti-1332	64	22	head	head	NOUN
dti-1332	64	23	and	and	CCONJ
dti-1332	64	24	hand	hand	NOUN
dti-1332	64	25	tremor	tremor	NOUN
dti-1332	64	26	,	,	PUNCT
dti-1332	64	27	akinesia	akinesia	PROPN
dti-1332	64	28	(	(	PUNCT
dti-1332	64	29	impaired	impaired	ADJ
dti-1332	64	30	muscle	muscle	NOUN
dti-1332	64	31	movement	movement	NOUN
dti-1332	64	32	)	)	PUNCT
dti-1332	64	33	,	,	PUNCT
dti-1332	64	34	subtle	subtle	ADJ
dti-1332	64	35	parkinsonism	parkinsonism	NOUN
dti-1332	64	36	possible	possible	ADJ
dti-1332	64	37	;	;	PUNCT
dti-1332	64	38	cognitive/	cognitive/	NUM
dti-1332	64	39	psychiatric	psychiatric	ADJ
dti-1332	64	40	disorders	disorder	NOUN
dti-1332	64	41	including	include	VERB
dti-1332	64	42	dementia	dementia	NOUN
dti-1332	64	43	holmes	holmes	PROPN
dti-1332	64	44	se	se	PROPN
dti-1332	64	45	et	et	PROPN
dti-1332	64	46	al	al	PROPN
dti-1332	64	47	.	.	PROPN
dti-1332	64	48	1999	1999	NUM
dti-1332	64	49	;	;	PUNCT
dti-1332	64	50	fujigasaki	fujigasaki	PROPN
dti-1332	64	51	et	et	PROPN
dti-1332	64	52	al	al	PROPN
dti-1332	64	53	.	.	PROPN
dti-1332	64	54	2001	2001	NUM
dti-1332	64	55	;	;	PUNCT
dti-1332	64	56	o’hearn	o’hearn	PROPN
dti-1332	64	57	et	et	PROPN
dti-1332	64	58	al	al	PROPN
dti-1332	64	59	.	.	PROPN
dti-1332	64	60	2001	2001	NUM
dti-1332	64	61	;	;	PUNCT
dti-1332	65	1	bahl	bahl	PROPN
dti-1332	65	2	et	et	PROPN
dti-1332	65	3	al	al	PROPN
dti-1332	65	4	.	.	PROPN
dti-1332	65	5	2005	2005	NUM
dti-1332	65	6	sca	sca	NOUN
dti-1332	65	7	13	13	NUM
dti-1332	65	8	19q13.3q13.4	19q13.3q13.4	NUM
dti-1332	65	9	potassium	potassium	NOUN
dti-1332	65	10	voltagegated	voltagegate	VERB
dti-1332	65	11	channel	channel	NOUN
dti-1332	65	12	subfamily	subfamily	ADV
dti-1332	65	13	c	c	PROPN
dti-1332	65	14	member	member	NOUN
dti-1332	65	15	3	3	NUM
dti-1332	65	16	childhood	childhood	NOUN
dti-1332	65	17	missense	missense	NOUN
dti-1332	65	18	mutation	mutation	NOUN
dti-1332	65	19	mental	mental	ADJ
dti-1332	65	20	retardation	retardation	NOUN
dti-1332	65	21	and	and	CCONJ
dti-1332	65	22	short	short	ADJ
dti-1332	65	23	stature	stature	NOUN
dti-1332	65	24	herman	herman	PROPN
dti-1332	65	25	-	-	PUNCT
dti-1332	65	26	bert	bert	PROPN
dti-1332	65	27	a	a	PRON
dti-1332	65	28	et	et	PROPN
dti-1332	65	29	al	al	PROPN
dti-1332	65	30	.	.	PROPN
dti-1332	65	31	2000	2000	NUM
dti-1332	65	32	;	;	PUNCT
dti-1332	65	33	waters	water	NOUN
dti-1332	65	34	et	et	PROPN
dti-1332	65	35	al	al	PROPN
dti-1332	65	36	.	.	PROPN
dti-1332	65	37	2006	2006	NUM
dti-1332	65	38	sca	sca	PROPN
dti-1332	65	39	14	14	NUM
dti-1332	65	40	19q13.4	19q13.4	NUM
dti-1332	65	41	protein	protein	NOUN
dti-1332	65	42	kinase	kinase	PROPN
dti-1332	65	43	c	c	PROPN
dti-1332	65	44	gamma	gamma	PROPN
dti-1332	65	45	type	type	NOUN
dti-1332	65	46	28	28	NUM
dti-1332	65	47	missense	missense	NOUN
dti-1332	65	48	mutation	mutation	NOUN
dti-1332	65	49	a	a	DET
dti-1332	65	50	sudden	sudden	ADJ
dti-1332	65	51	twitching	twitching	NOUN
dti-1332	65	52	of	of	ADP
dti-1332	65	53	muscles	muscle	NOUN
dti-1332	65	54	or	or	CCONJ
dti-1332	65	55	parts	part	NOUN
dti-1332	65	56	of	of	ADP
dti-1332	65	57	muscles	muscle	NOUN
dti-1332	65	58	,	,	PUNCT
dti-1332	65	59	without	without	ADP
dti-1332	65	60	any	any	DET
dti-1332	65	61	rhythm	rhythm	NOUN
dti-1332	65	62	or	or	CCONJ
dti-1332	65	63	pattern	pattern	NOUN
dti-1332	65	64	yamashita	yamashita	PROPN
dti-1332	66	1	i	i	PRON
dti-1332	66	2	et	et	PROPN
dti-1332	66	3	al	al	PROPN
dti-1332	66	4	.	.	PROPN
dti-1332	66	5	2000	2000	NUM
dti-1332	66	6	;	;	PUNCT
dti-1332	66	7	brkanac	brkanac	ADJ
dti-1332	66	8	z	z	PROPN
dti-1332	66	9	et	et	PROPN
dti-1332	66	10	al	al	PROPN
dti-1332	66	11	.	.	PROPN
dti-1332	66	12	2002	2002	NUM
dti-1332	66	13	;	;	PUNCT
dti-1332	66	14	warrenburg	warrenburg	PROPN
dti-1332	66	15	bpc	bpc	PROPN
dti-1332	66	16	et	et	PROPN
dti-1332	66	17	al	al	PROPN
dti-1332	66	18	.	.	PROPN
dti-1332	66	19	2003	2003	NUM
dti-1332	66	20	;	;	PUNCT
dti-1332	66	21	klebe	klebe	PROPN
dti-1332	66	22	s	s	PROPN
dti-1332	66	23	et	et	PROPN
dti-1332	66	24	al	al	PROPN
dti-1332	66	25	.	.	PROPN
dti-1332	66	26	2005	2005	NUM
dti-1332	66	27	;	;	PUNCT
dti-1332	66	28	chen	chen	PROPN
dti-1332	66	29	,	,	PUNCT
dti-1332	66	30	cimino	cimino	PROPN
dti-1332	66	31	et	et	PROPN
dti-1332	66	32	al	al	PROPN
dti-1332	66	33	.	.	PROPN
dti-1332	66	34	2003	2003	NUM
dti-1332	66	35	;	;	PUNCT
dti-1332	66	36	yabe	yabe	PROPN
dti-1332	66	37	et	et	PROPN
dti-1332	66	38	al	al	PROPN
dti-1332	66	39	.	.	PROPN
dti-1332	66	40	2003	2003	NUM
dti-1332	66	41	sca15	sca15	NOUN
dti-1332	66	42	3p26	3p26	NUM
dti-1332	66	43	-	-	PUNCT
dti-1332	66	44	p25	p25	NOUN
dti-1332	66	45	inositol	inositol	NOUN
dti-1332	66	46	1,4,5trisphosphate	1,4,5trisphosphate	NUM
dti-1332	66	47	receptor	receptor	NOUN
dti-1332	66	48	type	type	NOUN
dti-1332	66	49	1	1	NUM
dti-1332	66	50	unknown	unknown	ADJ
dti-1332	66	51	deletion	deletion	NOUN
dti-1332	66	52	of	of	ADP
dti-1332	66	53	the	the	DET
dti-1332	66	54	5	5	NUM
dti-1332	66	55	’	'	PUNCT
dti-1332	66	56	part	part	NOUN
dti-1332	66	57	of	of	ADP
dti-1332	66	58	the	the	DET
dti-1332	66	59	gene	gene	NOUN
dti-1332	66	60	pure	pure	ADJ
dti-1332	66	61	ataxia	ataxia	NOUN
dti-1332	66	62	,	,	PUNCT
dti-1332	66	63	very	very	ADV
dti-1332	66	64	slow	slow	ADJ
dti-1332	66	65	progression	progression	NOUN
dti-1332	66	66	van	van	PROPN
dti-1332	66	67	de	de	PROPN
dti-1332	66	68	leemput	leemput	PROPN
dti-1332	66	69	et	et	PROPN
dti-1332	66	70	al	al	PROPN
dti-1332	66	71	.	.	PROPN
dti-1332	66	72	2007	2007	NUM
dti-1332	66	73	;	;	PUNCT
dti-1332	66	74	knight	knight	PROPN
dti-1332	66	75	et	et	PROPN
dti-1332	66	76	al	al	PROPN
dti-1332	66	77	.	.	PROPN
dti-1332	66	78	2001	2001	NUM
dti-1332	66	79	;	;	PUNCT
dti-1332	66	80	storey	storey	NOUN
dti-1332	66	81	et	et	PROPN
dti-1332	66	82	al	al	PROPN
dti-1332	66	83	.	.	PROPN
dti-1332	66	84	2001	2001	NUM
dti-1332	66	85	;	;	PUNCT
dti-1332	66	86	knight	knight	PROPN
dti-1332	66	87	et	et	PROPN
dti-1332	66	88	al	al	PROPN
dti-1332	66	89	.	.	PROPN
dti-1332	66	90	2003	2003	NUM
dti-1332	67	1	sca	sca	NOUN
dti-1332	67	2	16	16	NUM
dti-1332	67	3	3p26.2	3p26.2	NUM
dti-1332	67	4	-	-	PUNCT
dti-1332	67	5	pter	pter	NOUN
dti-1332	67	6	contactin-4	contactin-4	NUM
dti-1332	67	7	39	39	NUM
dti-1332	67	8	unknown	unknown	ADJ
dti-1332	67	9	head	head	NOUN
dti-1332	67	10	and	and	CCONJ
dti-1332	67	11	hand	hand	NOUN
dti-1332	67	12	tremor	tremor	NOUN
dti-1332	67	13	miyoshi	miyoshi	PROPN
dti-1332	67	14	y	y	PROPN
dti-1332	67	15	et	et	PROPN
dti-1332	67	16	al	al	PROPN
dti-1332	67	17	.	.	PROPN
dti-1332	67	18	2001	2001	NUM
dti-1332	67	19	;	;	PUNCT
dti-1332	67	20	miura	miura	PROPN
dti-1332	67	21	et	et	PROPN
dti-1332	67	22	al	al	PROPN
dti-1332	67	23	.	.	PROPN
dti-1332	67	24	2006	2006	NUM
dti-1332	67	25	sca	sca	PROPN
dti-1332	67	26	17	17	NUM
dti-1332	67	27	6q27	6q27	NUM
dti-1332	67	28	tata	tata	NOUN
dti-1332	67	29	-	-	PUNCT
dti-1332	67	30	box	box	NOUN
dti-1332	67	31	binding	bind	VERB
dti-1332	67	32	protein	protein	NOUN
dti-1332	68	1	6–34	6–34	PROPN
dti-1332	68	2	caa/	caa/	NOUN
dti-1332	68	3	cag	cag	PROPN
dti-1332	68	4	repeat	repeat	NOUN
dti-1332	68	5	mutation	mutation	NOUN
dti-1332	68	6	worsening	worsen	VERB
dti-1332	68	7	of	of	ADP
dti-1332	68	8	mental	mental	ADJ
dti-1332	68	9	abilities	ability	NOUN
dti-1332	68	10	nakamura	nakamura	PROPN
dti-1332	68	11	k	k	PROPN
dti-1332	68	12	et	et	PROPN
dti-1332	68	13	al	al	PROPN
dti-1332	68	14	.	.	PROPN
dti-1332	68	15	2001	2001	NUM
dti-1332	68	16	;	;	PUNCT
dti-1332	68	17	maltecca	maltecca	NOUN
dti-1332	68	18	f	f	PROPN
dti-1332	68	19	et	et	PROPN
dti-1332	68	20	al	al	PROPN
dti-1332	68	21	.	.	PROPN
dti-1332	68	22	2003	2003	NUM
dti-1332	68	23	;	;	PUNCT
dti-1332	68	24	de	de	PROPN
dti-1332	68	25	michele	michele	PROPN
dti-1332	68	26	et	et	PROPN
dti-1332	68	27	al	al	PROPN
dti-1332	68	28	.	.	PROPN
dti-1332	68	29	2003	2003	NUM
dti-1332	68	30	;	;	PUNCT
dti-1332	68	31	lasek	lasek	NOUN
dti-1332	68	32	et	et	PROPN
dti-1332	68	33	al	al	PROPN
dti-1332	68	34	.	.	PROPN
dti-1332	68	35	2006	2006	NUM
dti-1332	68	36	(	(	PUNCT
dti-1332	68	37	continued	continue	VERB
dti-1332	68	38	)	)	PUNCT
dti-1332	68	39	103	103	NUM
dti-1332	68	40	recent	recent	ADJ
dti-1332	68	41	advancements	advancement	NOUN
dti-1332	68	42	in	in	ADP
dti-1332	68	43	targeted	target	VERB
dti-1332	68	44	delivery	delivery	NOUN
dti-1332	68	45	of	of	ADP
dti-1332	68	46	therapeutic	therapeutic	ADJ
dti-1332	68	47	molecules	molecule	NOUN
dti-1332	68	48	drug	drug	NOUN
dti-1332	68	49	target	target	NOUN
dti-1332	68	50	insights	insight	NOUN
dti-1332	68	51	2008:3	2008:3	NUM
dti-1332	68	52	table1	table1	PROPN
dti-1332	68	53	.	.	PUNCT
dti-1332	69	1	(	(	PUNCT
dti-1332	69	2	continued	continue	VERB
dti-1332	69	3	)	)	PUNCT
dti-1332	69	4	.	.	PUNCT
dti-1332	70	1	sca	sca	PROPN
dti-1332	70	2	subtype	subtype	NOUN
dti-1332	70	3	chromosome	chromosome	NOUN
dti-1332	70	4	locus	locus	NOUN
dti-1332	70	5	protein	protein	NOUN
dti-1332	70	6	name	name	NOUN
dti-1332	70	7	age	age	NOUN
dti-1332	70	8	onset	onset	NOUN
dti-1332	70	9	mutation	mutation	NOUN
dti-1332	70	10	symptoms	symptom	NOUN
dti-1332	70	11	references	reference	VERB
dti-1332	70	12	sca18	sca18	PROPN
dti-1332	70	13	7q22	7q22	NOUN
dti-1332	70	14	-	-	PUNCT
dti-1332	70	15	q32	q32	NOUN
dti-1332	70	16	unknown	unknown	ADJ
dti-1332	70	17	unknown	unknown	NOUN
dti-1332	70	18	sca19	sca19	VERB
dti-1332	70	19	1p21	1p21	NUM
dti-1332	70	20	-	-	PUNCT
dti-1332	70	21	q21	q21	NOUN
dti-1332	70	22	unknown	unknown	ADJ
dti-1332	70	23	34	34	NUM
dti-1332	70	24	unknown	unknown	ADJ
dti-1332	70	25	cognitive	cognitive	ADJ
dti-1332	70	26	impairment	impairment	NOUN
dti-1332	70	27	,	,	PUNCT
dti-1332	70	28	myoclonus	myoclonus	NOUN
dti-1332	70	29	(	(	PUNCT
dti-1332	70	30	muscle	muscle	NOUN
dti-1332	70	31	twitching	twitching	NOUN
dti-1332	70	32	)	)	PUNCT
dti-1332	70	33	,	,	PUNCT
dti-1332	70	34	tremor	tremor	NOUN
dti-1332	70	35	verbeek	verbeek	VERB
dti-1332	70	36	et	et	PROPN
dti-1332	70	37	al	al	PROPN
dti-1332	70	38	.	.	PROPN
dti-1332	70	39	2002	2002	NUM
dti-1332	70	40	;	;	PUNCT
dti-1332	70	41	chung	chung	PROPN
dti-1332	70	42	and	and	CCONJ
dti-1332	70	43	soong	soong	PROPN
dti-1332	70	44	2004	2004	NUM
dti-1332	70	45	;	;	PUNCT
dti-1332	70	46	schelhaas	schelhaas	VERB
dti-1332	70	47	et	et	PROPN
dti-1332	70	48	al	al	PROPN
dti-1332	70	49	.	.	PROPN
dti-1332	70	50	2004	2004	NUM
dti-1332	70	51	sca20	sca20	VERB
dti-1332	70	52	11p13	11p13	NUM
dti-1332	70	53	-	-	PUNCT
dti-1332	70	54	q11	q11	NOUN
dti-1332	70	55	unknown	unknown	ADJ
dti-1332	70	56	46	46	NUM
dti-1332	70	57	unknown	unknown	ADJ
dti-1332	70	58	early	early	ADJ
dti-1332	70	59	dysarthria	dysarthria	NOUN
dti-1332	70	60	(	(	PUNCT
dti-1332	70	61	motor	motor	NOUN
dti-1332	70	62	speech	speech	NOUN
dti-1332	70	63	disorder	disorder	NOUN
dti-1332	70	64	)	)	PUNCT
dti-1332	70	65	,	,	PUNCT
dti-1332	70	66	spasmodic	spasmodic	ADJ
dti-1332	70	67	dysphonia	dysphonia	NOUN
dti-1332	70	68	(	(	PUNCT
dti-1332	70	69	voice	voice	NOUN
dti-1332	70	70	disorder	disorder	NOUN
dti-1332	70	71	)	)	PUNCT
dti-1332	70	72	,	,	PUNCT
dti-1332	70	73	hyperrefl	hyperrefl	PROPN
dti-1332	70	74	exia	exia	PROPN
dti-1332	70	75	,	,	PUNCT
dti-1332	70	76	bradykinesia	bradykinesia	PROPN
dti-1332	70	77	(	(	PUNCT
dti-1332	70	78	slow	slow	ADJ
dti-1332	70	79	movement	movement	NOUN
dti-1332	70	80	)	)	PUNCT
dti-1332	70	81	knight	knight	NOUN
dti-1332	70	82	et	et	PROPN
dti-1332	70	83	al	al	PROPN
dti-1332	70	84	.	.	PROPN
dti-1332	70	85	2004	2004	NUM
dti-1332	71	1	sca21	sca21	ADJ
dti-1332	71	2	7p21	7p21	NUM
dti-1332	71	3	-	-	PUNCT
dti-1332	71	4	p15.1	p15.1	NOUN
dti-1332	71	5	unknown	unknown	ADJ
dti-1332	71	6	6–30	6–30	PROPN
dti-1332	71	7	unknown	unknown	ADJ
dti-1332	71	8	mild	mild	ADJ
dti-1332	71	9	cognitive	cognitive	ADJ
dti-1332	71	10	impairment	impairment	NOUN
dti-1332	71	11	vuillaume	vuillaume	NOUN
dti-1332	71	12	et	et	PROPN
dti-1332	71	13	al	al	PROPN
dti-1332	71	14	.	.	PROPN
dti-1332	71	15	2002	2002	NUM
dti-1332	71	16	;	;	PUNCT
dti-1332	71	17	devos	devos	PROPN
dti-1332	71	18	et	et	PROPN
dti-1332	71	19	al	al	PROPN
dti-1332	71	20	.	.	PROPN
dti-1332	71	21	2001	2001	NUM
dti-1332	72	1	sca22	sca22	PROPN
dti-1332	72	2	1p21	1p21	NUM
dti-1332	72	3	-	-	PUNCT
dti-1332	72	4	q21	q21	NOUN
dti-1332	72	5	unknown	unknown	ADJ
dti-1332	72	6	10–46	10–46	NUM
dti-1332	72	7	unknown	unknown	ADJ
dti-1332	72	8	slowly	slowly	ADV
dti-1332	72	9	progressive	progressive	ADJ
dti-1332	72	10	ataxia	ataxia	NOUN
dti-1332	72	11	chung	chung	PROPN
dti-1332	72	12	et	et	PROPN
dti-1332	72	13	al	al	PROPN
dti-1332	72	14	.	.	PROPN
dti-1332	72	15	2003	2003	NUM
dti-1332	72	16	sca23	sca23	NOUN
dti-1332	72	17	20p13	20p13	NUM
dti-1332	72	18	-	-	PUNCT
dti-1332	72	19	p12.3	p12.3	NOUN
dti-1332	72	20	unknown	unknown	ADJ
dti-1332	72	21	unknown	unknown	ADJ
dti-1332	72	22	dysarthria	dysarthria	NOUN
dti-1332	72	23	(	(	PUNCT
dti-1332	72	24	motor	motor	NOUN
dti-1332	72	25	speech	speech	NOUN
dti-1332	72	26	disorder	disorder	NOUN
dti-1332	72	27	)	)	PUNCT
dti-1332	72	28	,	,	PUNCT
dti-1332	72	29	abnormal	abnormal	ADJ
dti-1332	72	30	eye	eye	NOUN
dti-1332	72	31	movements	movement	NOUN
dti-1332	72	32	,	,	PUNCT
dti-1332	72	33	reduced	reduce	VERB
dti-1332	72	34	vibration	vibration	NOUN
dti-1332	72	35	and	and	CCONJ
dti-1332	72	36	position	position	NOUN
dti-1332	72	37	sense	sense	NOUN
dti-1332	72	38	verbeek	verbeek	VERB
dti-1332	72	39	et	et	PROPN
dti-1332	72	40	al	al	PROPN
dti-1332	72	41	.	.	PROPN
dti-1332	72	42	2002	2002	NUM
dti-1332	72	43	;	;	PUNCT
dti-1332	72	44	chung	chung	PROPN
dti-1332	72	45	et	et	PROPN
dti-1332	72	46	al	al	PROPN
dti-1332	72	47	.	.	PROPN
dti-1332	72	48	2003	2003	NUM
dti-1332	72	49	;	;	PUNCT
dti-1332	72	50	chung	chung	PROPN
dti-1332	72	51	and	and	CCONJ
dti-1332	72	52	soong	soong	PROPN
dti-1332	72	53	,	,	PUNCT
dti-1332	72	54	2004	2004	NUM
dti-1332	72	55	;	;	PUNCT
dti-1332	72	56	schelhaas	schelhaas	VERB
dti-1332	72	57	et	et	PROPN
dti-1332	72	58	al	al	PROPN
dti-1332	72	59	.	.	PROPN
dti-1332	72	60	2004	2004	NUM
dti-1332	72	61	;	;	PUNCT
dti-1332	72	62	verbeek	verbeek	NOUN
dti-1332	72	63	et	et	PROPN
dti-1332	72	64	al	al	PROPN
dti-1332	72	65	.	.	PROPN
dti-1332	72	66	2004	2004	NUM
dti-1332	73	1	sca25	sca25	PROPN
dti-1332	73	2	2p21	2p21	NUM
dti-1332	73	3	-	-	PUNCT
dti-1332	73	4	p13	p13	NOUN
dti-1332	73	5	unknown	unknown	ADJ
dti-1332	73	6	1.5–39	1.5–39	NOUN
dti-1332	73	7	unknown	unknown	ADJ
dti-1332	73	8	sensory	sensory	ADJ
dti-1332	73	9	neuropathy	neuropathy	ADJ
dti-1332	73	10	stevanin	stevanin	NOUN
dti-1332	73	11	et	et	PROPN
dti-1332	73	12	al	al	PROPN
dti-1332	73	13	.	.	PROPN
dti-1332	73	14	2003	2003	NUM
dti-1332	73	15	sca26	sca26	NOUN
dti-1332	73	16	19p13.3	19p13.3	PROPN
dti-1332	73	17	unknown	unknown	ADJ
dti-1332	73	18	26–60	26–60	PROPN
dti-1332	73	19	unknown	unknown	ADJ
dti-1332	73	20	dysarthria	dysarthria	NOUN
dti-1332	73	21	(	(	PUNCT
dti-1332	73	22	motor	motor	NOUN
dti-1332	73	23	speech	speech	NOUN
dti-1332	73	24	disorder	disorder	NOUN
dti-1332	73	25	)	)	PUNCT
dti-1332	73	26	,	,	PUNCT
dti-1332	73	27	irregular	irregular	ADJ
dti-1332	73	28	visual	visual	ADJ
dti-1332	73	29	pursuits	pursuit	NOUN
dti-1332	73	30	yu	yu	PROPN
dti-1332	73	31	et	et	PROPN
dti-1332	73	32	al	al	PROPN
dti-1332	73	33	.	.	PROPN
dti-1332	73	34	2005	2005	NUM
dti-1332	73	35	sca27	sca27	PROPN
dti-1332	73	36	13q34	13q34	NUM
dti-1332	73	37	fibroblast	fibroblast	ADJ
dti-1332	73	38	growth	growth	NOUN
dti-1332	73	39	factor	factor	NOUN
dti-1332	73	40	14	14	NUM
dti-1332	73	41	11	11	NUM
dti-1332	73	42	unknown	unknown	ADJ
dti-1332	73	43	early	early	ADJ
dti-1332	73	44	-	-	PUNCT
dti-1332	73	45	onset	onset	NOUN
dti-1332	73	46	tremor	tremor	NOUN
dti-1332	73	47	;	;	PUNCT
dti-1332	73	48	dyskinesia	dyskinesia	NOUN
dti-1332	73	49	(	(	PUNCT
dti-1332	73	50	involuntary	involuntary	ADJ
dti-1332	73	51	movements	movement	NOUN
dti-1332	73	52	)	)	PUNCT
dti-1332	73	53	,	,	PUNCT
dti-1332	73	54	cognitive	cognitive	ADJ
dti-1332	73	55	defi	defi	PROPN
dti-1332	73	56	cits	cits	PROPN
dti-1332	73	57	van	van	PROPN
dti-1332	73	58	swieten	swieten	PROPN
dti-1332	73	59	et	et	PROPN
dti-1332	73	60	al	al	PROPN
dti-1332	73	61	.	.	PROPN
dti-1332	73	62	2003	2003	NUM
dti-1332	73	63	;	;	PUNCT
dti-1332	73	64	brusse	brusse	NOUN
dti-1332	73	65	et	et	PROPN
dti-1332	73	66	al	al	PROPN
dti-1332	73	67	.	.	PROPN
dti-1332	73	68	2006	2006	NUM
dti-1332	73	69	sca28	sca28	PROPN
dti-1332	73	70	18p11.22q11.2	18p11.22q11.2	NUM
dti-1332	73	71	unknown	unknown	ADJ
dti-1332	73	72	19.5	19.5	NUM
dti-1332	73	73	unknown	unknown	ADJ
dti-1332	73	74	nystagmus	nystagmus	NOUN
dti-1332	73	75	(	(	PUNCT
dti-1332	73	76	involuntary	involuntary	ADJ
dti-1332	73	77	eye	eye	NOUN
dti-1332	73	78	movements	movement	NOUN
dti-1332	73	79	)	)	PUNCT
dti-1332	73	80	,	,	PUNCT
dti-1332	73	81	ophthalmoparesis	ophthalmoparesis	NOUN
dti-1332	73	82	(	(	PUNCT
dti-1332	73	83	paralysis	paralysis	NOUN
dti-1332	73	84	of	of	ADP
dti-1332	73	85	extra	extra	ADJ
dti-1332	73	86	ocular	ocular	ADJ
dti-1332	73	87	muscles	muscle	NOUN
dti-1332	73	88	,	,	PUNCT
dti-1332	73	89	responsible	responsible	ADJ
dti-1332	73	90	for	for	ADP
dti-1332	73	91	eye	eye	NOUN
dti-1332	73	92	movements	movement	NOUN
dti-1332	73	93	)	)	PUNCT
dti-1332	73	94	,	,	PUNCT
dti-1332	73	95	ptosis	ptosis	NOUN
dti-1332	73	96	(	(	PUNCT
dti-1332	73	97	droopiness	droopiness	ADJ
dti-1332	73	98	)	)	PUNCT
dti-1332	73	99	,	,	PUNCT
dti-1332	73	100	increased	increase	VERB
dti-1332	73	101	tendon	tendon	NOUN
dti-1332	73	102	refl	refl	PROPN
dti-1332	73	103	exes	exes	PROPN
dti-1332	73	104	cagnoli	cagnoli	PROPN
dti-1332	73	105	et	et	PROPN
dti-1332	73	106	al	al	PROPN
dti-1332	73	107	.	.	PROPN
dti-1332	73	108	2006	2006	NUM
dti-1332	73	109	dentatorubralpallidoluysian	dentatorubralpallidoluysian	ADJ
dti-1332	73	110	atrophy	atrophy	NOUN
dti-1332	73	111	(	(	PUNCT
dti-1332	73	112	drpla	drpla	ADJ
dti-1332	73	113	)	)	PUNCT
dti-1332	73	114	12p13.3	12p13.3	NUM
dti-1332	73	115	atrophin	atrophin	NOUN
dti-1332	73	116	i	i	PRON
dti-1332	73	117	8–20	8–20	PROPN
dti-1332	73	118	,	,	PUNCT
dti-1332	73	119	40–60	40–60	PROPN
dti-1332	73	120	cag	cag	PROPN
dti-1332	73	121	repeat	repeat	PROPN
dti-1332	73	122	chorea	chorea	PROPN
dti-1332	73	123	,	,	PUNCT
dti-1332	73	124	seizures	seizure	NOUN
dti-1332	73	125	,	,	PUNCT
dti-1332	73	126	dementia	dementia	NOUN
dti-1332	73	127	,	,	PUNCT
dti-1332	73	128	myoclonus	myoclonus	NOUN
dti-1332	73	129	(	(	PUNCT
dti-1332	73	130	muscle	muscle	NOUN
dti-1332	73	131	twitching	twitching	NOUN
dti-1332	73	132	)	)	PUNCT
dti-1332	73	133	koide	koide	NOUN
dti-1332	73	134	r	r	NOUN
dti-1332	73	135	et	et	PROPN
dti-1332	73	136	al	al	PROPN
dti-1332	73	137	.	.	PROPN
dti-1332	73	138	1994	1994	NUM
dti-1332	73	139	(	(	PUNCT
dti-1332	73	140	continued	continue	VERB
dti-1332	73	141	)	)	PUNCT
dti-1332	73	142	104	104	NUM
dti-1332	73	143	prakash	prakash	PROPN
dti-1332	73	144	and	and	CCONJ
dti-1332	73	145	malhotra	malhotra	PROPN
dti-1332	73	146	drug	drug	PROPN
dti-1332	73	147	target	target	NOUN
dti-1332	73	148	insights	insight	NOUN
dti-1332	73	149	2008:3	2008:3	NUM
dti-1332	73	150	table1	table1	PROPN
dti-1332	73	151	.	.	PUNCT
dti-1332	74	1	(	(	PUNCT
dti-1332	74	2	continued	continue	VERB
dti-1332	74	3	)	)	PUNCT
dti-1332	74	4	.	.	PUNCT
dti-1332	75	1	sca	sca	PROPN
dti-1332	75	2	subtype	subtype	NOUN
dti-1332	75	3	chromosome	chromosome	NOUN
dti-1332	75	4	locus	locus	NOUN
dti-1332	75	5	protein	protein	NOUN
dti-1332	75	6	name	name	NOUN
dti-1332	75	7	age	age	NOUN
dti-1332	75	8	onset	onset	NOUN
dti-1332	75	9	mutation	mutation	NOUN
dti-1332	75	10	symptoms	symptom	NOUN
dti-1332	75	11	references	reference	NOUN
dti-1332	75	12	episodic	episodic	ADJ
dti-1332	75	13	ataxia	ataxia	NOUN
dti-1332	75	14	(	(	PUNCT
dti-1332	75	15	ea1	ea1	NOUN
dti-1332	75	16	)	)	PUNCT
dti-1332	75	17	12p13	12p13	NUM
dti-1332	75	18	potassium	potassium	NOUN
dti-1332	75	19	voltagegated	voltagegate	VERB
dti-1332	75	20	channel	channel	NOUN
dti-1332	75	21	subfamily	subfamily	ADV
dti-1332	75	22	a	a	DET
dti-1332	75	23	member	member	NOUN
dti-1332	75	24	1	1	NUM
dti-1332	75	25	2–15	2–15	PROPN
dti-1332	75	26	unknown	unknown	ADJ
dti-1332	75	27	myokymia	myokymia	NOUN
dti-1332	75	28	;	;	PUNCT
dti-1332	75	29	muscle	muscle	NOUN
dti-1332	75	30	twitch	twitch	NOUN
dti-1332	75	31	attacks	attack	NOUN
dti-1332	75	32	lasting	last	VERB
dti-1332	75	33	seconds	second	NOUN
dti-1332	75	34	to	to	ADP
dti-1332	75	35	minutes	minute	NOUN
dti-1332	75	36	;	;	PUNCT
dti-1332	75	37	startle	startle	VERB
dti-1332	75	38	or	or	CCONJ
dti-1332	75	39	exercise	exercise	NOUN
dti-1332	75	40	induced	induce	VERB
dti-1332	75	41	;	;	PUNCT
dti-1332	75	42	no	no	DET
dti-1332	75	43	vertigo	vertigo	VERB
dti-1332	75	44	episodic	episodic	ADJ
dti-1332	75	45	ataxia	ataxia	NOUN
dti-1332	75	46	(	(	PUNCT
dti-1332	75	47	ea2	ea2	PROPN
dti-1332	75	48	)	)	PUNCT
dti-1332	76	1	19p13/2q22q23	19p13/2q22q23	NUM
dti-1332	76	2	voltagedependent	voltagedependent	NOUN
dti-1332	76	3	p	p	X
dti-1332	76	4	/	/	SYM
dti-1332	76	5	q	q	ADJ
dti-1332	76	6	-	-	PUNCT
dti-1332	76	7	type	type	NOUN
dti-1332	76	8	calcium	calcium	NOUN
dti-1332	76	9	channel	channel	NOUN
dti-1332	76	10	alpha-1a	alpha-1a	X
dti-1332	76	11	subunit/	subunit/	NUM
dti-1332	76	12	voltagedependent	voltagedependent	NOUN
dti-1332	76	13	l	l	NOUN
dti-1332	76	14	-	-	PUNCT
dti-1332	76	15	type	type	NOUN
dti-1332	76	16	calcium	calcium	NOUN
dti-1332	76	17	beta-4	beta-4	PROPN
dti-1332	76	18	subunit	subunit	NOUN
dti-1332	76	19	3–52	3–52	PROPN
dti-1332	76	20	unknown	unknown	ADJ
dti-1332	76	21	nystagmus	nystagmus	NOUN
dti-1332	76	22	(	(	PUNCT
dti-1332	76	23	involuntary	involuntary	ADJ
dti-1332	76	24	eye	eye	NOUN
dti-1332	76	25	movements	movement	NOUN
dti-1332	76	26	)	)	PUNCT
dti-1332	76	27	;	;	PUNCT
dti-1332	76	28	attacks	attack	NOUN
dti-1332	76	29	lasting	last	VERB
dti-1332	76	30	minutes	minute	NOUN
dti-1332	76	31	to	to	ADP
dti-1332	76	32	hours	hour	NOUN
dti-1332	76	33	;	;	PUNCT
dti-1332	76	34	posture	posture	NOUN
dti-1332	76	35	change	change	NOUN
dti-1332	76	36	induced	induce	VERB
dti-1332	76	37	;	;	PUNCT
dti-1332	77	1	vertigo	vertigo	NOUN
dti-1332	77	2	;	;	PUNCT
dti-1332	77	3	later	later	ADV
dti-1332	77	4	,	,	PUNCT
dti-1332	77	5	permanent	permanent	ADJ
dti-1332	77	6	ataxia	ataxia	NOUN
dti-1332	77	7	autosomal	autosomal	ADJ
dti-1332	77	8	dominant	dominant	ADJ
dti-1332	77	9	spastic	spastic	ADJ
dti-1332	77	10	ataxia	ataxia	NOUN
dti-1332	77	11	(	(	PUNCT
dti-1332	77	12	adsa	adsa	NOUN
dti-1332	77	13	)	)	PUNCT
dti-1332	77	14	12p13	12p13	NUM
dti-1332	77	15	unknown	unknown	ADJ
dti-1332	77	16	10–20	10–20	NUM
dti-1332	77	17	unknown	unknown	ADJ
dti-1332	77	18	initial	initial	ADJ
dti-1332	77	19	progressive	progressive	ADJ
dti-1332	77	20	leg	leg	NOUN
dti-1332	77	21	spasticity	spasticity	NOUN
dti-1332	77	22	(	(	PUNCT
dti-1332	77	23	continuous	continuous	ADJ
dti-1332	77	24	contraction	contraction	NOUN
dti-1332	77	25	of	of	ADP
dti-1332	77	26	muscles	muscle	NOUN
dti-1332	77	27	)	)	PUNCT
dti-1332	77	28	meijer	meijer	NOUN
dti-1332	77	29	et	et	PROPN
dti-1332	77	30	al	al	PROPN
dti-1332	77	31	.	.	PROPN
dti-1332	77	32	2002	2002	NUM
dti-1332	77	33	the	the	DET
dti-1332	77	34	age	age	NOUN
dti-1332	77	35	of	of	ADP
dti-1332	77	36	25	25	NUM
dti-1332	77	37	years	year	NOUN
dti-1332	77	38	.	.	PUNCT
dti-1332	78	1	it	it	PRON
dti-1332	78	2	poses	pose	VERB
dti-1332	78	3	50	50	NUM
dti-1332	78	4	%	%	NOUN
dti-1332	78	5	chance	chance	NOUN
dti-1332	78	6	of	of	ADP
dti-1332	78	7	inheritance	inheritance	NOUN
dti-1332	78	8	and	and	CCONJ
dti-1332	78	9	requires	require	VERB
dti-1332	78	10	the	the	DET
dti-1332	78	11	presence	presence	NOUN
dti-1332	78	12	of	of	ADP
dti-1332	78	13	mutation	mutation	NOUN
dti-1332	78	14	in	in	ADP
dti-1332	78	15	only	only	ADV
dti-1332	78	16	one	one	NUM
dti-1332	78	17	of	of	ADP
dti-1332	78	18	the	the	DET
dti-1332	78	19	two	two	NUM
dti-1332	78	20	copies	copy	NOUN
dti-1332	78	21	of	of	ADP
dti-1332	78	22	a	a	DET
dti-1332	78	23	gene	gene	NOUN
dti-1332	78	24	(	(	PUNCT
dti-1332	78	25	maternal	maternal	ADJ
dti-1332	78	26	or	or	CCONJ
dti-1332	78	27	paternal	paternal	ADJ
dti-1332	78	28	)	)	PUNCT
dti-1332	78	29	to	to	PART
dti-1332	78	30	trigger	trigger	VERB
dti-1332	78	31	the	the	DET
dti-1332	78	32	onset	onset	NOUN
dti-1332	78	33	of	of	ADP
dti-1332	78	34	the	the	DET
dti-1332	78	35	disease	disease	NOUN
dti-1332	78	36	.	.	PUNCT
dti-1332	79	1	autosomal	autosomal	ADJ
dti-1332	79	2	recessive	recessive	ADJ
dti-1332	79	3	cerebellar	cerebellar	ADJ
dti-1332	79	4	ataxia	ataxia	NOUN
dti-1332	79	5	and	and	CCONJ
dti-1332	79	6	episodic	episodic	ADJ
dti-1332	79	7	ataxia	ataxia	NOUN
dti-1332	79	8	occurs	occur	VERB
dti-1332	79	9	before	before	ADP
dti-1332	79	10	25	25	NUM
dti-1332	79	11	years	year	NOUN
dti-1332	79	12	of	of	ADP
dti-1332	79	13	age	age	NOUN
dti-1332	79	14	(	(	PUNCT
dti-1332	79	15	worth	worth	ADJ
dti-1332	79	16	,	,	PUNCT
dti-1332	79	17	2004	2004	NUM
dti-1332	79	18	)	)	PUNCT
dti-1332	79	19	and	and	CCONJ
dti-1332	79	20	requires	require	VERB
dti-1332	79	21	the	the	DET
dti-1332	79	22	inheritance	inheritance	NOUN
dti-1332	79	23	of	of	ADP
dti-1332	79	24	the	the	DET
dti-1332	79	25	mutation	mutation	NOUN
dti-1332	79	26	in	in	ADP
dti-1332	79	27	both	both	CCONJ
dti-1332	79	28	maternal	maternal	ADJ
dti-1332	79	29	and	and	CCONJ
dti-1332	79	30	paternal	paternal	ADJ
dti-1332	79	31	genes	gene	NOUN
dti-1332	79	32	.	.	PUNCT
dti-1332	80	1	an	an	DET
dti-1332	80	2	allele	allele	NOUN
dti-1332	80	3	having	have	VERB
dti-1332	80	4	cag	cag	PROPN
dti-1332	80	5	triplets	triplet	NOUN
dti-1332	80	6	within	within	ADP
dti-1332	80	7	the	the	DET
dti-1332	80	8	range	range	NOUN
dti-1332	80	9	of	of	ADP
dti-1332	80	10	14–35	14–35	NUM
dti-1332	80	11	with	with	ADP
dti-1332	80	12	one	one	NUM
dti-1332	80	13	or	or	CCONJ
dti-1332	80	14	more	more	ADJ
dti-1332	80	15	caa	caa	NOUN
dti-1332	80	16	interruption	interruption	NOUN
dti-1332	80	17	(	(	PUNCT
dti-1332	80	18	sobczak	sobczak	NOUN
dti-1332	80	19	et	et	PROPN
dti-1332	80	20	al	al	PROPN
dti-1332	80	21	.	.	PROPN
dti-1332	80	22	2005	2005	NUM
dti-1332	80	23	)	)	PUNCT
dti-1332	80	24	in	in	ADP
dti-1332	80	25	between	between	ADP
dti-1332	80	26	is	be	AUX
dti-1332	80	27	characterized	characterize	VERB
dti-1332	80	28	as	as	ADP
dti-1332	80	29	a	a	DET
dti-1332	80	30	normal	normal	ADJ
dti-1332	80	31	allele	allele	NOUN
dti-1332	80	32	that	that	PRON
dti-1332	80	33	results	result	VERB
dti-1332	80	34	in	in	ADP
dti-1332	80	35	the	the	DET
dti-1332	80	36	formation	formation	NOUN
dti-1332	80	37	of	of	ADP
dti-1332	80	38	a	a	DET
dti-1332	80	39	protein	protein	NOUN
dti-1332	80	40	called	call	VERB
dti-1332	80	41	ataxin	ataxin	NOUN
dti-1332	80	42	.	.	PUNCT
dti-1332	81	1	whereas	whereas	SCONJ
dti-1332	81	2	,	,	PUNCT
dti-1332	81	3	an	an	DET
dti-1332	81	4	allele	allele	NOUN
dti-1332	81	5	having	have	VERB
dti-1332	81	6	more	more	ADJ
dti-1332	81	7	than	than	ADP
dti-1332	81	8	35	35	NUM
dti-1332	81	9	to	to	PART
dti-1332	81	10	45	45	NUM
dti-1332	81	11	continuous	continuous	ADJ
dti-1332	81	12	cag	cag	PROPN
dti-1332	81	13	triplets	triplet	NOUN
dti-1332	81	14	is	be	AUX
dti-1332	81	15	characterized	characterize	VERB
dti-1332	81	16	as	as	ADP
dti-1332	81	17	an	an	DET
dti-1332	81	18	abnormal	abnormal	ADJ
dti-1332	81	19	allele	allele	NOUN
dti-1332	81	20	(	(	PUNCT
dti-1332	81	21	ross	ross	PROPN
dti-1332	81	22	et	et	PROPN
dti-1332	81	23	al	al	PROPN
dti-1332	81	24	.	.	PROPN
dti-1332	81	25	2003	2003	NUM
dti-1332	81	26	)	)	PUNCT
dti-1332	81	27	,	,	PUNCT
dti-1332	81	28	which	which	PRON
dti-1332	81	29	results	result	VERB
dti-1332	81	30	in	in	ADP
dti-1332	81	31	the	the	DET
dti-1332	81	32	formation	formation	NOUN
dti-1332	81	33	of	of	ADP
dti-1332	81	34	an	an	DET
dti-1332	81	35	abnormal	abnormal	ADJ
dti-1332	81	36	/	/	SYM
dti-1332	81	37	mutant	mutant	ADJ
dti-1332	81	38	protein	protein	NOUN
dti-1332	81	39	.	.	PUNCT
dti-1332	82	1	figure	figure	NOUN
dti-1332	82	2	1	1	NUM
dti-1332	82	3	summarizes	summarize	NOUN
dti-1332	82	4	the	the	DET
dti-1332	82	5	implication	implication	NOUN
dti-1332	82	6	of	of	ADP
dti-1332	82	7	cag	cag	PROPN
dti-1332	82	8	repeat	repeat	NOUN
dti-1332	82	9	sizes	size	NOUN
dti-1332	82	10	on	on	ADP
dti-1332	82	11	the	the	DET
dti-1332	82	12	disease	disease	NOUN
dti-1332	82	13	.	.	PUNCT
dti-1332	83	1	the	the	DET
dti-1332	83	2	abnormal	abnormal	ADJ
dti-1332	83	3	protein	protein	NOUN
dti-1332	83	4	formed	form	VERB
dti-1332	83	5	not	not	PART
dti-1332	83	6	only	only	ADV
dti-1332	83	7	accumulates	accumulate	VERB
dti-1332	83	8	within	within	ADP
dti-1332	83	9	the	the	DET
dti-1332	83	10	purkinje	purkinje	PROPN
dti-1332	83	11	cells	cell	NOUN
dti-1332	83	12	(	(	PUNCT
dti-1332	83	13	neurons	neuron	NOUN
dti-1332	83	14	)	)	PUNCT
dti-1332	83	15	of	of	ADP
dti-1332	83	16	the	the	DET
dti-1332	83	17	brain	brain	NOUN
dti-1332	83	18	(	(	PUNCT
dti-1332	83	19	lin	lin	PROPN
dti-1332	83	20	et	et	PROPN
dti-1332	83	21	al	al	PROPN
dti-1332	83	22	.	.	PROPN
dti-1332	83	23	2000	2000	NUM
dti-1332	83	24	)	)	PUNCT
dti-1332	83	25	but	but	CCONJ
dti-1332	83	26	have	have	AUX
dti-1332	83	27	also	also	ADV
dti-1332	83	28	been	be	AUX
dti-1332	83	29	observed	observe	VERB
dti-1332	83	30	to	to	PART
dti-1332	83	31	affect	affect	VERB
dti-1332	83	32	the	the	DET
dti-1332	83	33	cytoplasm	cytoplasm	NOUN
dti-1332	83	34	,	,	PUNCT
dti-1332	83	35	dendrites	dendrite	NOUN
dti-1332	83	36	and	and	CCONJ
dti-1332	83	37	axonal	axonal	ADJ
dti-1332	83	38	processes	process	NOUN
dti-1332	83	39	.	.	PUNCT
dti-1332	84	1	it	it	PRON
dti-1332	84	2	is	be	AUX
dti-1332	84	3	still	still	ADV
dti-1332	84	4	a	a	DET
dti-1332	84	5	controversy	controversy	NOUN
dti-1332	84	6	as	as	ADP
dti-1332	84	7	to	to	ADP
dti-1332	84	8	whether	whether	SCONJ
dti-1332	84	9	the	the	DET
dti-1332	84	10	formation	formation	NOUN
dti-1332	84	11	of	of	ADP
dti-1332	84	12	inclusion	inclusion	NOUN
dti-1332	84	13	bodies	body	NOUN
dti-1332	84	14	confers	confer	VERB
dti-1332	84	15	a	a	DET
dti-1332	84	16	toxic	toxic	ADJ
dti-1332	84	17	effect	effect	NOUN
dti-1332	84	18	on	on	ADP
dti-1332	84	19	neurons	neuron	NOUN
dti-1332	84	20	or	or	CCONJ
dti-1332	84	21	is	be	AUX
dti-1332	84	22	actually	actually	ADV
dti-1332	84	23	the	the	DET
dti-1332	84	24	response	response	NOUN
dti-1332	84	25	of	of	ADP
dti-1332	84	26	the	the	DET
dti-1332	84	27	cellular	cellular	ADJ
dti-1332	84	28	protective	protective	ADJ
dti-1332	84	29	mechanism	mechanism	NOUN
dti-1332	84	30	(	(	PUNCT
dti-1332	84	31	kopito	kopito	X
dti-1332	84	32	,	,	PUNCT
dti-1332	84	33	2000	2000	NUM
dti-1332	84	34	)	)	PUNCT
dti-1332	84	35	.	.	PUNCT
dti-1332	85	1	but	but	CCONJ
dti-1332	85	2	they	they	PRON
dti-1332	85	3	defi	defi	VERB
dti-1332	85	4	nitely	nitely	ADV
dti-1332	85	5	act	act	VERB
dti-1332	85	6	as	as	ADP
dti-1332	85	7	biomarkers	biomarker	NOUN
dti-1332	85	8	providing	provide	VERB
dti-1332	85	9	clues	clue	NOUN
dti-1332	85	10	for	for	ADP
dti-1332	85	11	pathogenicity	pathogenicity	NOUN
dti-1332	85	12	(	(	PUNCT
dti-1332	85	13	coon	coon	NOUN
dti-1332	85	14	et	et	PROPN
dti-1332	85	15	al	al	PROPN
dti-1332	85	16	.	.	PROPN
dti-1332	85	17	2004	2004	NUM
dti-1332	85	18	)	)	PUNCT
dti-1332	85	19	.	.	PUNCT
dti-1332	86	1	also	also	ADV
dti-1332	86	2	,	,	PUNCT
dti-1332	86	3	the	the	DET
dti-1332	86	4	formation	formation	NOUN
dti-1332	86	5	of	of	ADP
dti-1332	86	6	inclusion	inclusion	NOUN
dti-1332	86	7	bodies	body	NOUN
dti-1332	86	8	inhibits	inhibit	VERB
dti-1332	86	9	the	the	DET
dti-1332	86	10	ubiquitin	ubiquitin	ADJ
dti-1332	86	11	-	-	PUNCT
dti-1332	86	12	proteasome	proteasome	NOUN
dti-1332	86	13	pathway	pathway	NOUN
dti-1332	86	14	(	(	PUNCT
dti-1332	86	15	holmberg	holmberg	PROPN
dti-1332	86	16	et	et	PROPN
dti-1332	86	17	al	al	PROPN
dti-1332	86	18	.	.	PROPN
dti-1332	86	19	2004	2004	NUM
dti-1332	86	20	;	;	PUNCT
dti-1332	86	21	park	park	NOUN
dti-1332	86	22	et	et	PROPN
dti-1332	86	23	al	al	PROPN
dti-1332	86	24	.	.	PROPN
dti-1332	86	25	2005	2005	NUM
dti-1332	86	26	)	)	PUNCT
dti-1332	86	27	,	,	PUNCT
dti-1332	86	28	which	which	PRON
dti-1332	86	29	also	also	ADV
dti-1332	86	30	relates	relate	VERB
dti-1332	86	31	to	to	ADP
dti-1332	86	32	neurotoxicity	neurotoxicity	NOUN
dti-1332	86	33	.	.	PUNCT
dti-1332	87	1	figure	figure	NOUN
dti-1332	87	2	1	1	NUM
dti-1332	87	3	.	.	PUNCT
dti-1332	88	1	(	(	PUNCT
dti-1332	88	2	a	a	X
dti-1332	88	3	)	)	PUNCT
dti-1332	88	4	the	the	DET
dti-1332	88	5	upper	upper	ADJ
dti-1332	88	6	and	and	CCONJ
dti-1332	88	7	lower	low	ADJ
dti-1332	88	8	cag	cag	PROPN
dti-1332	88	9	repeat	repeat	NOUN
dti-1332	88	10	sizes	size	NOUN
dti-1332	88	11	indicate	indicate	VERB
dti-1332	88	12	disease	disease	NOUN
dti-1332	88	13	and	and	CCONJ
dti-1332	88	14	normal	normal	ADJ
dti-1332	88	15	allele	allele	NOUN
dti-1332	88	16	sizes	size	NOUN
dti-1332	88	17	respectively	respectively	ADV
dti-1332	88	18	.	.	PUNCT
dti-1332	89	1	(	(	PUNCT
dti-1332	89	2	b	b	X
dti-1332	89	3	)	)	PUNCT
dti-1332	89	4	the	the	DET
dti-1332	89	5	abnormal	abnormal	ADJ
dti-1332	89	6	allele	allele	NOUN
dti-1332	89	7	has	have	VERB
dti-1332	89	8	continuous	continuous	ADJ
dti-1332	89	9	cag	cag	PROPN
dti-1332	89	10	repeats	repeat	NOUN
dti-1332	89	11	whereas	whereas	SCONJ
dti-1332	89	12	normal	normal	ADJ
dti-1332	89	13	allele	allele	NOUN
dti-1332	89	14	has	have	AUX
dti-1332	89	15	caa	caa	NOUN
dti-1332	89	16	interruptions	interruption	NOUN
dti-1332	89	17	in	in	ADP
dti-1332	89	18	between	between	ADP
dti-1332	89	19	cag	cag	PROPN
dti-1332	89	20	repeats	repeat	NOUN
dti-1332	89	21	.	.	PUNCT
dti-1332	90	1	105	105	NUM
dti-1332	90	2	recent	recent	ADJ
dti-1332	90	3	advancements	advancement	NOUN
dti-1332	90	4	in	in	ADP
dti-1332	90	5	targeted	target	VERB
dti-1332	90	6	delivery	delivery	NOUN
dti-1332	90	7	of	of	ADP
dti-1332	90	8	therapeutic	therapeutic	ADJ
dti-1332	90	9	molecules	molecule	NOUN
dti-1332	90	10	drug	drug	NOUN
dti-1332	90	11	target	target	NOUN
dti-1332	90	12	insights	insight	VERB
dti-1332	90	13	2008:3	2008:3	NUM
dti-1332	90	14	pathogenic	pathogenic	ADJ
dti-1332	90	15	pathway	pathway	NOUN
dti-1332	90	16	—	—	PUNCT
dti-1332	90	17	formation	formation	NOUN
dti-1332	90	18	of	of	ADP
dti-1332	90	19	aggregates	aggregate	NOUN
dti-1332	90	20	and	and	CCONJ
dti-1332	90	21	inclusion	inclusion	NOUN
dti-1332	90	22	bodies	body	NOUN
dti-1332	90	23	the	the	DET
dti-1332	90	24	pathogenic	pathogenic	ADJ
dti-1332	90	25	pathway	pathway	NOUN
dti-1332	90	26	involved	involve	VERB
dti-1332	90	27	in	in	ADP
dti-1332	90	28	polyglutamine	polyglutamine	NOUN
dti-1332	90	29	aggregation	aggregation	NOUN
dti-1332	90	30	is	be	AUX
dti-1332	90	31	similar	similar	ADJ
dti-1332	90	32	to	to	ADP
dti-1332	90	33	its	its	PRON
dti-1332	90	34	related	relate	VERB
dti-1332	90	35	diseases	disease	NOUN
dti-1332	90	36	like	like	ADP
dti-1332	90	37	alzheimer	alzheimer	NOUN
dti-1332	90	38	involving	involve	VERB
dti-1332	90	39	aβ	aβ	DET
dti-1332	90	40	protein	protein	NOUN
dti-1332	90	41	and	and	CCONJ
dti-1332	90	42	parkinson	parkinson	NOUN
dti-1332	90	43	’s	’s	PART
dti-1332	90	44	involving	involve	VERB
dti-1332	90	45	αsynuclein	αsynuclein	NOUN
dti-1332	90	46	that	that	PRON
dti-1332	90	47	causes	cause	VERB
dti-1332	90	48	neurodegenerative	neurodegenerative	ADJ
dti-1332	90	49	diseases	disease	NOUN
dti-1332	90	50	(	(	PUNCT
dti-1332	90	51	ross	ross	PROPN
dti-1332	90	52	et	et	PROPN
dti-1332	90	53	al	al	PROPN
dti-1332	90	54	.	.	PROPN
dti-1332	90	55	2003	2003	NUM
dti-1332	90	56	)	)	PUNCT
dti-1332	90	57	.	.	PUNCT
dti-1332	91	1	biophysical	biophysical	ADJ
dti-1332	91	2	analysis	analysis	NOUN
dti-1332	91	3	of	of	ADP
dti-1332	91	4	expanded	expand	VERB
dti-1332	91	5	polyglutamine	polyglutamine	NOUN
dti-1332	91	6	aggregates	aggregate	NOUN
dti-1332	91	7	using	use	VERB
dti-1332	91	8	various	various	ADJ
dti-1332	91	9	methods	method	NOUN
dti-1332	91	10	like	like	ADP
dti-1332	91	11	x	x	NOUN
dti-1332	91	12	-	-	NOUN
dti-1332	91	13	ray	ray	NOUN
dti-1332	91	14	fi	fi	NOUN
dti-1332	91	15	ber	ber	NOUN
dti-1332	91	16	diffraction	diffraction	NOUN
dti-1332	91	17	,	,	PUNCT
dti-1332	91	18	circular	circular	ADJ
dti-1332	91	19	dichroism	dichroism	NOUN
dti-1332	91	20	,	,	PUNCT
dti-1332	91	21	fourier	fourier	NOUN
dti-1332	91	22	transform	transform	NOUN
dti-1332	91	23	infra	infra	NOUN
dti-1332	91	24	red	red	ADJ
dti-1332	91	25	spectroscopy	spectroscopy	NOUN
dti-1332	91	26	revealed	reveal	VERB
dti-1332	91	27	an	an	DET
dti-1332	91	28	antiparallel	antiparallel	ADJ
dti-1332	91	29	β	β	ADJ
dti-1332	91	30	-	-	ADJ
dti-1332	91	31	sheet	sheet	ADJ
dti-1332	91	32	structure	structure	NOUN
dti-1332	91	33	of	of	ADP
dti-1332	91	34	protein	protein	NOUN
dti-1332	91	35	aggregates	aggregate	NOUN
dti-1332	91	36	(	(	PUNCT
dti-1332	91	37	perutz	perutz	ADJ
dti-1332	91	38	,	,	PUNCT
dti-1332	91	39	1999	1999	NUM
dti-1332	91	40	;	;	PUNCT
dti-1332	91	41	chen	chen	PROPN
dti-1332	91	42	et	et	PROPN
dti-1332	91	43	al	al	PROPN
dti-1332	91	44	.	.	PROPN
dti-1332	91	45	2002	2002	NUM
dti-1332	91	46	;	;	PUNCT
dti-1332	91	47	poirier	poirier	PROPN
dti-1332	91	48	et	et	PROPN
dti-1332	91	49	al	al	PROPN
dti-1332	91	50	.	.	PROPN
dti-1332	91	51	2002	2002	NUM
dti-1332	91	52	)	)	PUNCT
dti-1332	91	53	described	describe	VERB
dti-1332	91	54	as	as	ADP
dti-1332	91	55	“	"	PUNCT
dti-1332	91	56	polar	polar	ADJ
dti-1332	91	57	zipper	zipper	NOUN
dti-1332	91	58	”	"	PUNCT
dti-1332	91	59	by	by	ADP
dti-1332	91	60	max	max	PROPN
dti-1332	91	61	perutz	perutz	PROPN
dti-1332	91	62	(	(	PUNCT
dti-1332	91	63	perutz	perutz	ADJ
dti-1332	91	64	,	,	PUNCT
dti-1332	91	65	1994	1994	NUM
dti-1332	91	66	)	)	PUNCT
dti-1332	91	67	.	.	PUNCT
dti-1332	92	1	inclusion	inclusion	NOUN
dti-1332	92	2	bodies	body	NOUN
dti-1332	92	3	are	be	AUX
dti-1332	92	4	the	the	DET
dti-1332	92	5	main	main	ADJ
dti-1332	92	6	sources	source	NOUN
dti-1332	92	7	causing	cause	VERB
dti-1332	92	8	the	the	DET
dti-1332	92	9	onset	onset	NOUN
dti-1332	92	10	of	of	ADP
dti-1332	92	11	disease	disease	NOUN
dti-1332	92	12	.	.	PUNCT
dti-1332	93	1	their	their	PRON
dti-1332	93	2	formation	formation	NOUN
dti-1332	93	3	involves	involve	VERB
dti-1332	93	4	two	two	NUM
dti-1332	93	5	suggestive	suggestive	ADJ
dti-1332	93	6	models	model	NOUN
dti-1332	93	7	:	:	PUNCT
dti-1332	93	8	thakur	thakur	NOUN
dti-1332	93	9	and	and	CCONJ
dti-1332	93	10	wetzel	wetzel	PROPN
dti-1332	93	11	proposed	propose	VERB
dti-1332	93	12	that	that	SCONJ
dti-1332	93	13	the	the	DET
dti-1332	93	14	unfolded	unfold	VERB
dti-1332	93	15	polyglutamine	polyglutamine	NOUN
dti-1332	93	16	monomers	monomer	NOUN
dti-1332	93	17	undergo	undergo	VERB
dti-1332	93	18	a	a	DET
dti-1332	93	19	structural	structural	ADJ
dti-1332	93	20	transition	transition	NOUN
dti-1332	93	21	after	after	ADP
dti-1332	93	22	the	the	DET
dti-1332	93	23	nucleation	nucleation	NOUN
dti-1332	93	24	activities	activity	NOUN
dti-1332	93	25	resulting	result	VERB
dti-1332	93	26	in	in	ADP
dti-1332	93	27	an	an	DET
dti-1332	93	28	antiparallel	antiparallel	ADJ
dti-1332	93	29	four	four	NUM
dti-1332	93	30	-	-	PUNCT
dti-1332	93	31	stranded	strand	VERB
dti-1332	93	32	β	β	NOUN
dti-1332	93	33	-	-	ADJ
dti-1332	93	34	sheet	sheet	NOUN
dti-1332	93	35	helix	helix	NOUN
dti-1332	93	36	,	,	PUNCT
dti-1332	93	37	where	where	SCONJ
dti-1332	93	38	each	each	DET
dti-1332	93	39	sheet	sheet	NOUN
dti-1332	93	40	comprises	comprise	NOUN
dti-1332	93	41	of	of	ADP
dti-1332	93	42	seven	seven	NUM
dti-1332	93	43	glutamine	glutamine	NOUN
dti-1332	93	44	residues	residue	NOUN
dti-1332	93	45	.	.	PUNCT
dti-1332	94	1	this	this	DET
dti-1332	94	2	acts	act	VERB
dti-1332	94	3	as	as	ADP
dti-1332	94	4	a	a	DET
dti-1332	94	5	nucleus	nucleus	NOUN
dti-1332	94	6	to	to	PART
dti-1332	94	7	which	which	PRON
dti-1332	94	8	similar	similar	ADJ
dti-1332	94	9	structurally	structurally	ADV
dti-1332	94	10	transitioned	transition	VERB
dti-1332	94	11	monomers	monomer	NOUN
dti-1332	94	12	forming	form	VERB
dti-1332	94	13	β	β	NOUN
dti-1332	94	14	-	-	NOUN
dti-1332	94	15	sheets	sheet	NOUN
dti-1332	94	16	come	come	VERB
dti-1332	94	17	together	together	ADV
dti-1332	94	18	and	and	CCONJ
dti-1332	94	19	set	set	VERB
dti-1332	94	20	alternatively	alternatively	ADV
dti-1332	94	21	resulting	result	VERB
dti-1332	94	22	in	in	ADP
dti-1332	94	23	an	an	DET
dti-1332	94	24	elongated	elongated	ADJ
dti-1332	94	25	strand	strand	NOUN
dti-1332	94	26	.	.	PUNCT
dti-1332	95	1	another	another	DET
dti-1332	95	2	pathway	pathway	NOUN
dti-1332	95	3	suggested	suggest	VERB
dti-1332	95	4	was	be	AUX
dti-1332	95	5	based	base	VERB
dti-1332	95	6	on	on	ADP
dti-1332	95	7	the	the	DET
dti-1332	95	8	biochemical	biochemical	ADJ
dti-1332	95	9	and	and	CCONJ
dti-1332	95	10	morphological	morphological	ADJ
dti-1332	95	11	studies	study	NOUN
dti-1332	95	12	of	of	ADP
dti-1332	95	13	polyglutamine	polyglutamine	NOUN
dti-1332	95	14	aggregates	aggregate	NOUN
dti-1332	95	15	which	which	PRON
dti-1332	95	16	involves	involve	VERB
dti-1332	95	17	the	the	DET
dti-1332	95	18	assembly	assembly	NOUN
dti-1332	95	19	of	of	ADP
dti-1332	95	20	oligomeric	oligomeric	ADJ
dti-1332	95	21	intermediates	intermediate	NOUN
dti-1332	95	22	resulting	result	VERB
dti-1332	95	23	in	in	ADP
dti-1332	95	24	the	the	DET
dti-1332	95	25	formation	formation	NOUN
dti-1332	95	26	of	of	ADP
dti-1332	95	27	protofi	protofi	ADJ
dti-1332	95	28	brils	bril	NOUN
dti-1332	95	29	followed	follow	VERB
dti-1332	95	30	by	by	ADP
dti-1332	95	31	fi	fi	NOUN
dti-1332	95	32	bril	bril	ADJ
dti-1332	95	33	formation	formation	NOUN
dti-1332	95	34	and	and	CCONJ
dti-1332	95	35	ultimately	ultimately	ADV
dti-1332	95	36	inclusion	inclusion	NOUN
dti-1332	95	37	bodies	body	NOUN
dti-1332	95	38	are	be	AUX
dti-1332	95	39	formed	form	VERB
dti-1332	95	40	(	(	PUNCT
dti-1332	95	41	ross	ross	PROPN
dti-1332	95	42	et	et	PROPN
dti-1332	95	43	al	al	PROPN
dti-1332	95	44	.	.	PROPN
dti-1332	95	45	2003	2003	NUM
dti-1332	95	46	)	)	PUNCT
dti-1332	95	47	(	(	PUNCT
dti-1332	95	48	fig	fig	NOUN
dti-1332	95	49	.	.	PUNCT
dti-1332	96	1	2	2	NUM
dti-1332	96	2	)	)	PUNCT
dti-1332	96	3	.	.	PUNCT
dti-1332	97	1	the	the	DET
dti-1332	97	2	pathogenic	pathogenic	ADJ
dti-1332	97	3	mechanism	mechanism	NOUN
dti-1332	97	4	involving	involve	VERB
dti-1332	97	5	proteolytic	proteolytic	ADJ
dti-1332	97	6	cleavage	cleavage	NOUN
dti-1332	97	7	and	and	CCONJ
dti-1332	97	8	accumulation	accumulation	NOUN
dti-1332	97	9	of	of	ADP
dti-1332	97	10	protein	protein	NOUN
dti-1332	97	11	is	be	AUX
dti-1332	97	12	toxic	toxic	ADJ
dti-1332	97	13	to	to	ADP
dti-1332	97	14	the	the	DET
dti-1332	97	15	nucleus	nucleus	NOUN
dti-1332	97	16	(	(	PUNCT
dti-1332	97	17	cummings	cummings	PROPN
dti-1332	97	18	et	et	PROPN
dti-1332	97	19	al	al	PROPN
dti-1332	97	20	.	.	PROPN
dti-1332	97	21	2000	2000	NUM
dti-1332	97	22	)	)	PUNCT
dti-1332	97	23	.	.	PUNCT
dti-1332	98	1	the	the	DET
dti-1332	98	2	proteolytic	proteolytic	ADJ
dti-1332	98	3	cleavage	cleavage	NOUN
dti-1332	98	4	releases	release	NOUN
dti-1332	98	5	toxic	toxic	ADJ
dti-1332	98	6	fragments	fragment	NOUN
dti-1332	98	7	that	that	PRON
dti-1332	98	8	contain	contain	VERB
dti-1332	98	9	an	an	DET
dti-1332	98	10	expanded	expand	VERB
dti-1332	98	11	polyglutamine	polyglutamine	NOUN
dti-1332	98	12	tail	tail	NOUN
dti-1332	98	13	and	and	CCONJ
dti-1332	98	14	further	far	ADV
dti-1332	98	15	enhances	enhance	VERB
dti-1332	98	16	the	the	DET
dti-1332	98	17	entry	entry	NOUN
dti-1332	98	18	of	of	ADP
dti-1332	98	19	cytoplasmic	cytoplasmic	ADJ
dti-1332	98	20	proteins	protein	NOUN
dti-1332	98	21	into	into	ADP
dti-1332	98	22	the	the	DET
dti-1332	98	23	nucleus	nucleus	NOUN
dti-1332	98	24	,	,	PUNCT
dti-1332	98	25	the	the	DET
dti-1332	98	26	mechanism	mechanism	NOUN
dti-1332	98	27	of	of	ADP
dti-1332	98	28	which	which	PRON
dti-1332	98	29	is	be	AUX
dti-1332	98	30	still	still	ADV
dti-1332	98	31	not	not	PART
dti-1332	98	32	clearly	clearly	ADV
dti-1332	98	33	understood	understand	VERB
dti-1332	98	34	.	.	PUNCT
dti-1332	99	1	other	other	ADJ
dti-1332	99	2	processes	process	NOUN
dti-1332	99	3	like	like	ADP
dti-1332	99	4	apoptotic	apoptotic	ADJ
dti-1332	99	5	activation	activation	NOUN
dti-1332	99	6	,	,	PUNCT
dti-1332	99	7	accumulation	accumulation	NOUN
dti-1332	99	8	,	,	PUNCT
dti-1332	99	9	misfolding	misfolding	NOUN
dti-1332	99	10	,	,	PUNCT
dti-1332	99	11	aggregation	aggregation	NOUN
dti-1332	99	12	,	,	PUNCT
dti-1332	99	13	and	and	CCONJ
dti-1332	99	14	sequestration	sequestration	NOUN
dti-1332	99	15	of	of	ADP
dti-1332	99	16	other	other	ADJ
dti-1332	99	17	proteins	protein	NOUN
dti-1332	99	18	such	such	ADJ
dti-1332	99	19	as	as	ADP
dti-1332	99	20	transcription	transcription	NOUN
dti-1332	99	21	factors	factor	NOUN
dti-1332	99	22	and	and	CCONJ
dti-1332	99	23	chaperones	chaperone	NOUN
dti-1332	99	24	,	,	PUNCT
dti-1332	99	25	leading	lead	VERB
dti-1332	99	26	to	to	ADP
dti-1332	99	27	dysfunction	dysfunction	NOUN
dti-1332	99	28	of	of	ADP
dti-1332	99	29	proteins	protein	NOUN
dti-1332	99	30	and	and	CCONJ
dti-1332	99	31	their	their	PRON
dti-1332	99	32	intranuclear	intranuclear	NOUN
dti-1332	99	33	or	or	CCONJ
dti-1332	99	34	intracellular	intracellular	ADJ
dti-1332	99	35	accumulation	accumulation	NOUN
dti-1332	99	36	adds	add	VERB
dti-1332	99	37	up	up	ADP
dti-1332	99	38	to	to	ADP
dti-1332	99	39	the	the	DET
dti-1332	99	40	disease	disease	NOUN
dti-1332	99	41	process	process	NOUN
dti-1332	99	42	.	.	PUNCT
dti-1332	100	1	clinical	clinical	ADJ
dti-1332	100	2	therapeutic	therapeutic	ADJ
dti-1332	100	3	options	option	NOUN
dti-1332	100	4	although	although	SCONJ
dti-1332	100	5	,	,	PUNCT
dti-1332	100	6	certain	certain	ADJ
dti-1332	100	7	medicines	medicine	NOUN
dti-1332	100	8	have	have	AUX
dti-1332	100	9	shown	show	VERB
dti-1332	100	10	to	to	PART
dti-1332	100	11	give	give	VERB
dti-1332	100	12	a	a	DET
dti-1332	100	13	temporary	temporary	ADJ
dti-1332	100	14	relief	relief	NOUN
dti-1332	100	15	from	from	ADP
dti-1332	100	16	the	the	DET
dti-1332	100	17	severity	severity	NOUN
dti-1332	100	18	of	of	ADP
dti-1332	100	19	the	the	DET
dti-1332	100	20	symptoms	symptom	NOUN
dti-1332	100	21	like	like	ADP
dti-1332	100	22	tremors	tremor	NOUN
dti-1332	100	23	etc	etc	X
dti-1332	100	24	,	,	PUNCT
dti-1332	100	25	currently	currently	ADV
dti-1332	100	26	,	,	PUNCT
dti-1332	100	27	there	there	PRON
dti-1332	100	28	is	be	VERB
dti-1332	100	29	no	no	DET
dti-1332	100	30	treatment	treatment	NOUN
dti-1332	100	31	available	available	ADJ
dti-1332	100	32	for	for	ADP
dti-1332	100	33	ataxia	ataxia	NOUN
dti-1332	100	34	that	that	PRON
dti-1332	100	35	may	may	AUX
dti-1332	100	36	halt	halt	VERB
dti-1332	100	37	the	the	DET
dti-1332	100	38	progression	progression	NOUN
dti-1332	100	39	of	of	ADP
dti-1332	100	40	the	the	DET
dti-1332	100	41	disease	disease	NOUN
dti-1332	100	42	.	.	PUNCT
dti-1332	101	1	the	the	DET
dti-1332	101	2	reason	reason	NOUN
dti-1332	101	3	for	for	ADP
dti-1332	101	4	the	the	DET
dti-1332	101	5	absence	absence	NOUN
dti-1332	101	6	of	of	ADP
dti-1332	101	7	available	available	ADJ
dti-1332	101	8	medication	medication	NOUN
dti-1332	101	9	for	for	ADP
dti-1332	101	10	sca	sca	PROPN
dti-1332	101	11	could	could	AUX
dti-1332	101	12	be	be	AUX
dti-1332	101	13	attributed	attribute	VERB
dti-1332	101	14	to	to	ADP
dti-1332	101	15	the	the	DET
dti-1332	101	16	genetic	genetic	ADJ
dti-1332	101	17	problem	problem	NOUN
dti-1332	101	18	associated	associate	VERB
dti-1332	101	19	with	with	ADP
dti-1332	101	20	it	it	PRON
dti-1332	101	21	;	;	PUNCT
dti-1332	101	22	that	that	PRON
dti-1332	101	23	is	be	AUX
dti-1332	101	24	the	the	DET
dti-1332	101	25	cell	cell	NOUN
dti-1332	101	26	can	can	AUX
dti-1332	101	27	not	not	PART
dti-1332	101	28	be	be	AUX
dti-1332	101	29	arrested	arrest	VERB
dti-1332	101	30	to	to	PART
dti-1332	101	31	stop	stop	VERB
dti-1332	101	32	producing	produce	VERB
dti-1332	101	33	poly	poly	ADJ
dti-1332	101	34	glutamine	glutamine	NOUN
dti-1332	101	35	as	as	ADP
dti-1332	101	36	otherwise	otherwise	ADV
dti-1332	101	37	it	it	PRON
dti-1332	101	38	would	would	AUX
dti-1332	101	39	interfere	interfere	VERB
dti-1332	101	40	with	with	ADP
dti-1332	101	41	the	the	DET
dti-1332	101	42	function	function	NOUN
dti-1332	101	43	of	of	ADP
dti-1332	101	44	brain	brain	NOUN
dti-1332	101	45	cells	cell	NOUN
dti-1332	101	46	and	and	CCONJ
dti-1332	101	47	thus	thus	ADV
dti-1332	101	48	will	will	AUX
dti-1332	101	49	produce	produce	VERB
dti-1332	101	50	side	side	NOUN
dti-1332	101	51	effects	effect	NOUN
dti-1332	101	52	which	which	PRON
dti-1332	101	53	may	may	AUX
dti-1332	101	54	in	in	ADP
dti-1332	101	55	turn	turn	NOUN
dti-1332	101	56	require	require	VERB
dti-1332	101	57	further	further	ADJ
dti-1332	101	58	treatment	treatment	NOUN
dti-1332	101	59	.	.	PUNCT
dti-1332	102	1	table	table	NOUN
dti-1332	102	2	2	2	NUM
dti-1332	102	3	summarizes	summarize	NOUN
dti-1332	102	4	available	available	ADJ
dti-1332	102	5	drugs	drug	NOUN
dti-1332	102	6	that	that	PRON
dti-1332	102	7	have	have	AUX
dti-1332	102	8	been	be	AUX
dti-1332	102	9	used	use	VERB
dti-1332	102	10	to	to	PART
dti-1332	102	11	alleviate	alleviate	VERB
dti-1332	102	12	the	the	DET
dti-1332	102	13	symptoms	symptom	NOUN
dti-1332	102	14	of	of	ADP
dti-1332	102	15	ataxia	ataxia	NOUN
dti-1332	102	16	.	.	PUNCT
dti-1332	103	1	apart	apart	ADV
dti-1332	103	2	from	from	ADP
dti-1332	103	3	these	these	DET
dti-1332	103	4	drugs	drug	NOUN
dti-1332	103	5	,	,	PUNCT
dti-1332	103	6	clinical	clinical	ADJ
dti-1332	103	7	management	management	NOUN
dti-1332	103	8	of	of	ADP
dti-1332	103	9	the	the	DET
dti-1332	103	10	disease	disease	NOUN
dti-1332	103	11	involves	involve	VERB
dti-1332	103	12	providing	provide	VERB
dti-1332	103	13	the	the	DET
dti-1332	103	14	patient	patient	NOUN
dti-1332	103	15	with	with	ADP
dti-1332	103	16	canes	cane	NOUN
dti-1332	103	17	and	and	CCONJ
dti-1332	103	18	wheelchairs	wheelchairs	NOUN
dti-1332	103	19	for	for	ADP
dti-1332	103	20	coordination	coordination	NOUN
dti-1332	103	21	of	of	ADP
dti-1332	103	22	the	the	DET
dti-1332	103	23	body	body	NOUN
dti-1332	103	24	movement	movement	NOUN
dti-1332	103	25	and	and	CCONJ
dti-1332	103	26	use	use	NOUN
dti-1332	103	27	of	of	ADP
dti-1332	103	28	biomedical	biomedical	ADJ
dti-1332	103	29	devices	device	NOUN
dti-1332	103	30	that	that	PRON
dti-1332	103	31	help	help	VERB
dti-1332	103	32	the	the	DET
dti-1332	103	33	person	person	NOUN
dti-1332	103	34	to	to	PART
dti-1332	103	35	perform	perform	VERB
dti-1332	103	36	daily	daily	ADJ
dti-1332	103	37	-	-	PUNCT
dti-1332	103	38	routine	routine	ADJ
dti-1332	103	39	duties	duty	NOUN
dti-1332	103	40	like	like	ADP
dti-1332	103	41	eating	eat	VERB
dti-1332	103	42	,	,	PUNCT
dti-1332	103	43	writing	writing	NOUN
dti-1332	103	44	etc	etc	X
dti-1332	103	45	.	.	X
dti-1332	104	1	with	with	ADP
dti-1332	104	2	ease	ease	NOUN
dti-1332	104	3	.	.	PUNCT
dti-1332	105	1	there	there	PRON
dti-1332	105	2	are	be	VERB
dti-1332	105	3	certain	certain	ADJ
dti-1332	105	4	drugs	drug	NOUN
dti-1332	105	5	like	like	ADP
dti-1332	105	6	deferipone	deferipone	NOUN
dti-1332	105	7	and	and	CCONJ
dti-1332	105	8	idebenone	idebenone	NOUN
dti-1332	105	9	(	(	PUNCT
dti-1332	105	10	di	di	NOUN
dti-1332	105	11	prospero	prospero	NOUN
dti-1332	105	12	na	na	NOUN
dti-1332	105	13	et	et	PROPN
dti-1332	105	14	al	al	PROPN
dti-1332	105	15	.	.	PROPN
dti-1332	105	16	2007	2007	NUM
dti-1332	105	17	)	)	PUNCT
dti-1332	105	18	that	that	PRON
dti-1332	105	19	have	have	AUX
dti-1332	105	20	reached	reach	VERB
dti-1332	105	21	phase	phase	NOUN
dti-1332	105	22	ii	ii	PROPN
dti-1332	105	23	and	and	CCONJ
dti-1332	105	24	iii	iii	NOUN
dti-1332	105	25	respectively	respectively	ADV
dti-1332	105	26	of	of	ADP
dti-1332	105	27	their	their	PRON
dti-1332	105	28	clinical	clinical	ADJ
dti-1332	105	29	trials	trial	NOUN
dti-1332	105	30	but	but	CCONJ
dti-1332	105	31	are	be	AUX
dti-1332	105	32	limited	limit	VERB
dti-1332	105	33	to	to	ADP
dti-1332	105	34	friedreich	friedreich	PROPN
dti-1332	105	35	’s	’s	PART
dti-1332	105	36	ataxia	ataxia	NOUN
dti-1332	105	37	(	(	PUNCT
dti-1332	105	38	autosomal	autosomal	ADJ
dti-1332	105	39	recessive	recessive	ADJ
dti-1332	105	40	cerebellar	cerebellar	ADJ
dti-1332	105	41	ataxia	ataxia	NOUN
dti-1332	105	42	)	)	PUNCT
dti-1332	105	43	.	.	PUNCT
dti-1332	106	1	several	several	ADJ
dti-1332	106	2	other	other	ADJ
dti-1332	106	3	reports	report	NOUN
dti-1332	106	4	on	on	ADP
dti-1332	106	5	the	the	DET
dti-1332	106	6	active	active	ADJ
dti-1332	106	7	and	and	CCONJ
dti-1332	106	8	completed	complete	VERB
dti-1332	106	9	clinical	clinical	ADJ
dti-1332	106	10	trials	trial	NOUN
dti-1332	106	11	of	of	ADP
dti-1332	106	12	other	other	ADJ
dti-1332	106	13	related	related	ADJ
dti-1332	106	14	neurodegenerative	neurodegenerative	ADJ
dti-1332	106	15	diseases	disease	NOUN
dti-1332	106	16	can	can	AUX
dti-1332	106	17	also	also	ADV
dti-1332	106	18	be	be	AUX
dti-1332	106	19	found	find	VERB
dti-1332	106	20	at	at	ADP
dti-1332	106	21	clinicaltrials.gov	clinicaltrials.gov	PROPN
dti-1332	106	22	.	.	PUNCT
dti-1332	106	23	figure	figure	NOUN
dti-1332	106	24	2	2	NUM
dti-1332	106	25	.	.	PUNCT
dti-1332	106	26	model	model	NOUN
dti-1332	106	27	of	of	ADP
dti-1332	106	28	polyglutamine	polyglutamine	NOUN
dti-1332	106	29	initiation	initiation	NOUN
dti-1332	106	30	and	and	CCONJ
dti-1332	106	31	elongation	elongation	NOUN
dti-1332	106	32	depicting	depict	VERB
dti-1332	106	33	the	the	DET
dti-1332	106	34	pathway	pathway	NOUN
dti-1332	106	35	of	of	ADP
dti-1332	106	36	formation	formation	NOUN
dti-1332	106	37	of	of	ADP
dti-1332	106	38	inclusion	inclusion	NOUN
dti-1332	106	39	bodies	body	NOUN
dti-1332	106	40	(	(	PUNCT
dti-1332	106	41	adopted	adopt	VERB
dti-1332	106	42	and	and	CCONJ
dti-1332	106	43	modifi	modifi	NOUN
dti-1332	106	44	ed	ed	PROPN
dti-1332	106	45	from	from	ADP
dti-1332	106	46	ross	ross	PROPN
dti-1332	106	47	et	et	PROPN
dti-1332	106	48	al	al	PROPN
dti-1332	106	49	.	.	PROPN
dti-1332	106	50	2003	2003	NUM
dti-1332	106	51	)	)	PUNCT
dti-1332	106	52	.	.	PUNCT
dti-1332	107	1	106	106	NUM
dti-1332	107	2	prakash	prakash	PROPN
dti-1332	107	3	and	and	CCONJ
dti-1332	107	4	malhotra	malhotra	PROPN
dti-1332	107	5	drug	drug	PROPN
dti-1332	107	6	target	target	NOUN
dti-1332	107	7	insights	insight	VERB
dti-1332	107	8	2008:3	2008:3	NUM
dti-1332	107	9	research	research	NOUN
dti-1332	107	10	and	and	CCONJ
dti-1332	107	11	therapeutics	therapeutic	NOUN
dti-1332	107	12	—	—	PUNCT
dti-1332	107	13	rnai	rnai	PROPN
dti-1332	107	14	,	,	PUNCT
dti-1332	107	15	a	a	DET
dti-1332	107	16	new	new	ADJ
dti-1332	107	17	technology	technology	NOUN
dti-1332	107	18	for	for	ADP
dti-1332	107	19	treating	treat	VERB
dti-1332	107	20	ataxia	ataxia	NOUN
dti-1332	107	21	one	one	NUM
dti-1332	107	22	of	of	ADP
dti-1332	107	23	the	the	DET
dti-1332	107	24	promising	promising	ADJ
dti-1332	107	25	technology	technology	NOUN
dti-1332	107	26	is	be	AUX
dti-1332	107	27	the	the	DET
dti-1332	107	28	use	use	NOUN
dti-1332	107	29	of	of	ADP
dti-1332	107	30	rna	rna	NOUN
dti-1332	107	31	interference	interference	NOUN
dti-1332	107	32	(	(	PUNCT
dti-1332	107	33	rnai	rnai	PROPN
dti-1332	107	34	)	)	PUNCT
dti-1332	107	35	to	to	PART
dti-1332	107	36	treat	treat	VERB
dti-1332	107	37	ataxia	ataxia	NOUN
dti-1332	107	38	.	.	PUNCT
dti-1332	108	1	research	research	NOUN
dti-1332	108	2	is	be	AUX
dti-1332	108	3	being	be	AUX
dti-1332	108	4	carried	carry	VERB
dti-1332	108	5	out	out	ADP
dti-1332	108	6	in	in	ADP
dti-1332	108	7	this	this	DET
dti-1332	108	8	area	area	NOUN
dti-1332	108	9	to	to	PART
dti-1332	108	10	develop	develop	VERB
dti-1332	108	11	therapeutic	therapeutic	ADJ
dti-1332	108	12	techniques	technique	NOUN
dti-1332	108	13	targeting	target	VERB
dti-1332	108	14	the	the	DET
dti-1332	108	15	associated	associated	ADJ
dti-1332	108	16	snp	snp	ADJ
dti-1332	108	17	variant	variant	NOUN
dti-1332	108	18	(	(	PUNCT
dti-1332	108	19	miller	miller	PROPN
dti-1332	108	20	et	et	PROPN
dti-1332	108	21	al	al	PROPN
dti-1332	108	22	.	.	PROPN
dti-1332	108	23	2003	2003	NUM
dti-1332	108	24	)	)	PUNCT
dti-1332	108	25	by	by	ADP
dti-1332	108	26	developing	develop	VERB
dti-1332	108	27	specifi	specifi	PROPN
dti-1332	108	28	c	c	PROPN
dti-1332	108	29	small	small	ADJ
dti-1332	108	30	interfering	interfere	VERB
dti-1332	108	31	rna	rna	PROPN
dti-1332	108	32	(	(	PUNCT
dti-1332	108	33	sirna	sirna	PROPN
dti-1332	108	34	)	)	PUNCT
dti-1332	108	35	,	,	PUNCT
dti-1332	108	36	which	which	PRON
dti-1332	108	37	will	will	AUX
dti-1332	108	38	silence	silence	VERB
dti-1332	108	39	the	the	DET
dti-1332	108	40	effect	effect	NOUN
dti-1332	108	41	of	of	ADP
dti-1332	108	42	mutant	mutant	ADJ
dti-1332	108	43	gene	gene	NOUN
dti-1332	108	44	(	(	PUNCT
dti-1332	108	45	forte	forte	PROPN
dti-1332	108	46	et	et	PROPN
dti-1332	108	47	al	al	PROPN
dti-1332	108	48	.	.	PROPN
dti-1332	108	49	2005	2005	NUM
dti-1332	108	50	)	)	PUNCT
dti-1332	108	51	.	.	PUNCT
dti-1332	109	1	sirnas	sirnas	PROPN
dti-1332	109	2	,	,	PUNCT
dti-1332	109	3	also	also	ADV
dti-1332	109	4	known	know	VERB
dti-1332	109	5	as	as	ADP
dti-1332	109	6	“	"	PUNCT
dti-1332	109	7	guide	guide	VERB
dti-1332	109	8	rnas	rna	NOUN
dti-1332	109	9	”	"	PUNCT
dti-1332	109	10	,	,	PUNCT
dti-1332	109	11	are	be	AUX
dti-1332	109	12	19	19	NUM
dti-1332	109	13	to	to	ADP
dti-1332	109	14	21bp	21bp	ADJ
dti-1332	109	15	long	long	ADJ
dti-1332	109	16	duplexes	duplex	NOUN
dti-1332	109	17	with	with	ADP
dti-1332	109	18	2	2	NUM
dti-1332	109	19	-	-	PUNCT
dti-1332	109	20	nucleotide	nucleotide	ADJ
dti-1332	109	21	3	3	NUM
dti-1332	109	22	’	'	PUNCT
dti-1332	109	23	overhangs	overhang	NOUN
dti-1332	109	24	(	(	PUNCT
dti-1332	109	25	bernstein	bernstein	PROPN
dti-1332	109	26	et	et	PROPN
dti-1332	109	27	al	al	PROPN
dti-1332	109	28	.	.	PROPN
dti-1332	109	29	2001	2001	NUM
dti-1332	109	30	;	;	PUNCT
dti-1332	109	31	hutvagner	hutvagner	NOUN
dti-1332	109	32	and	and	CCONJ
dti-1332	109	33	zamore	zamore	PROPN
dti-1332	109	34	,	,	PUNCT
dti-1332	109	35	2002	2002	NUM
dti-1332	109	36	)	)	PUNCT
dti-1332	109	37	corresponding	correspond	VERB
dti-1332	109	38	to	to	ADP
dti-1332	109	39	both	both	DET
dti-1332	109	40	sense	sense	NOUN
dti-1332	109	41	and	and	CCONJ
dti-1332	109	42	antisense	antisense	NOUN
dti-1332	109	43	strands	strand	NOUN
dti-1332	109	44	of	of	ADP
dti-1332	109	45	a	a	DET
dti-1332	109	46	targeted	target	VERB
dti-1332	109	47	gene	gene	NOUN
dti-1332	109	48	(	(	PUNCT
dti-1332	109	49	hamilton	hamilton	PROPN
dti-1332	109	50	and	and	CCONJ
dti-1332	109	51	baulcombe	baulcombe	NOUN
dti-1332	109	52	,	,	PUNCT
dti-1332	109	53	1999	1999	NUM
dti-1332	109	54	;	;	PUNCT
dti-1332	109	55	voinnet	voinnet	NOUN
dti-1332	109	56	,	,	PUNCT
dti-1332	109	57	2002	2002	NUM
dti-1332	109	58	)	)	PUNCT
dti-1332	109	59	.	.	PUNCT
dti-1332	110	1	they	they	PRON
dti-1332	110	2	are	be	AUX
dti-1332	110	3	formed	form	VERB
dti-1332	110	4	when	when	SCONJ
dti-1332	110	5	a	a	DET
dti-1332	110	6	dicer	dicer	NOUN
dti-1332	110	7	molecule	molecule	NOUN
dti-1332	110	8	(	(	PUNCT
dti-1332	110	9	rnase	rnase	PROPN
dti-1332	110	10	iii	iii	NUM
dti-1332	110	11	type	type	NOUN
dti-1332	110	12	enzyme	enzyme	NOUN
dti-1332	110	13	)	)	PUNCT
dti-1332	110	14	dices	dice	VERB
dti-1332	110	15	the	the	DET
dti-1332	110	16	dsrna	dsrna	NOUN
dti-1332	110	17	(	(	PUNCT
dti-1332	110	18	introduced	introduce	VERB
dti-1332	110	19	directly	directly	ADV
dti-1332	110	20	or	or	CCONJ
dti-1332	110	21	via	via	ADP
dti-1332	110	22	a	a	DET
dti-1332	110	23	transgene	transgene	NOUN
dti-1332	110	24	or	or	CCONJ
dti-1332	110	25	virus	virus	NOUN
dti-1332	110	26	)	)	PUNCT
dti-1332	110	27	.	.	PUNCT
dti-1332	111	1	rnai	rnai	PROPN
dti-1332	111	2	is	be	AUX
dti-1332	111	3	an	an	DET
dti-1332	111	4	effective	effective	ADJ
dti-1332	111	5	and	and	CCONJ
dti-1332	111	6	an	an	DET
dti-1332	111	7	effi	effi	PROPN
dti-1332	111	8	cient	cient	NOUN
dti-1332	111	9	natural	natural	ADJ
dti-1332	111	10	process	process	NOUN
dti-1332	111	11	,	,	PUNCT
dti-1332	111	12	which	which	PRON
dti-1332	111	13	prevents	prevent	VERB
dti-1332	111	14	viral	viral	ADJ
dti-1332	111	15	infection	infection	NOUN
dti-1332	111	16	.	.	PUNCT
dti-1332	112	1	it	it	PRON
dti-1332	112	2	was	be	AUX
dti-1332	112	3	fi	fi	NOUN
dti-1332	112	4	rst	rst	PROPN
dti-1332	112	5	documented	document	VERB
dti-1332	112	6	in	in	ADP
dti-1332	112	7	the	the	DET
dti-1332	112	8	plant	plant	NOUN
dti-1332	112	9	petunia	petunia	NOUN
dti-1332	112	10	and	and	CCONJ
dti-1332	112	11	then	then	ADV
dti-1332	112	12	later	later	ADV
dti-1332	112	13	in	in	ADP
dti-1332	112	14	other	other	ADJ
dti-1332	112	15	plant	plant	NOUN
dti-1332	112	16	species	specie	NOUN
dti-1332	112	17	(	(	PUNCT
dti-1332	112	18	napoli	napoli	PROPN
dti-1332	112	19	et	et	PROPN
dti-1332	112	20	al	al	PROPN
dti-1332	112	21	.	.	PROPN
dti-1332	112	22	1990	1990	NUM
dti-1332	112	23	)	)	PUNCT
dti-1332	112	24	.	.	PUNCT
dti-1332	113	1	experiments	experiment	NOUN
dti-1332	113	2	in	in	ADP
dti-1332	113	3	caenorhabditis	caenorhabditis	ADJ
dti-1332	113	4	elegans	elegan	NOUN
dti-1332	113	5	(	(	PUNCT
dti-1332	113	6	fire	fire	NOUN
dti-1332	113	7	and	and	CCONJ
dti-1332	113	8	mello	mello	PROPN
dti-1332	113	9	,	,	PUNCT
dti-1332	113	10	1998	1998	NUM
dti-1332	113	11	)	)	PUNCT
dti-1332	113	12	and	and	CCONJ
dti-1332	113	13	drosophila	drosophila	NOUN
dti-1332	113	14	(	(	PUNCT
dti-1332	113	15	elbashir	elbashir	VERB
dti-1332	113	16	et	et	PROPN
dti-1332	113	17	al	al	PROPN
dti-1332	113	18	.	.	PROPN
dti-1332	113	19	2001	2001	NUM
dti-1332	113	20	)	)	PUNCT
dti-1332	113	21	revealed	reveal	VERB
dti-1332	113	22	that	that	SCONJ
dti-1332	113	23	the	the	DET
dti-1332	113	24	same	same	ADJ
dti-1332	113	25	phenomenon	phenomenon	NOUN
dti-1332	113	26	also	also	ADV
dti-1332	113	27	occurs	occur	VERB
dti-1332	113	28	in	in	ADP
dti-1332	113	29	animal	animal	NOUN
dti-1332	113	30	systems	system	NOUN
dti-1332	113	31	.	.	PUNCT
dti-1332	114	1	the	the	DET
dti-1332	114	2	dsrna	dsrna	NOUN
dti-1332	114	3	when	when	SCONJ
dti-1332	114	4	processed	process	VERB
dti-1332	114	5	by	by	ADP
dti-1332	114	6	dicer	dicer	NOUN
dti-1332	114	7	into	into	ADP
dti-1332	114	8	sirnas	sirnas	PROPN
dti-1332	114	9	is	be	AUX
dti-1332	114	10	recruited	recruit	VERB
dti-1332	114	11	into	into	ADP
dti-1332	114	12	nuclease	nuclease	NOUN
dti-1332	114	13	complex	complex	NOUN
dti-1332	114	14	to	to	PART
dti-1332	114	15	form	form	VERB
dti-1332	114	16	the	the	DET
dti-1332	114	17	rna	rna	NOUN
dti-1332	114	18	induced	induce	VERB
dti-1332	114	19	silencing	silence	VERB
dti-1332	114	20	complex	complex	NOUN
dti-1332	114	21	,	,	PUNCT
dti-1332	114	22	or	or	CCONJ
dti-1332	114	23	risc	risc	PROPN
dti-1332	114	24	.	.	PUNCT
dti-1332	115	1	risc	risc	PROPN
dti-1332	115	2	facilitates	facilitate	VERB
dti-1332	115	3	the	the	DET
dti-1332	115	4	unwinding	unwinding	NOUN
dti-1332	115	5	of	of	ADP
dti-1332	115	6	sirna	sirna	PROPN
dti-1332	115	7	,	,	PUNCT
dti-1332	115	8	the	the	DET
dti-1332	115	9	one	one	NOUN
dti-1332	115	10	with	with	ADP
dti-1332	115	11	the	the	DET
dti-1332	115	12	antisense	antisense	NOUN
dti-1332	115	13	strand	strand	NOUN
dti-1332	115	14	is	be	AUX
dti-1332	115	15	retained	retain	VERB
dti-1332	115	16	within	within	ADP
dti-1332	115	17	the	the	DET
dti-1332	115	18	complex	complex	NOUN
dti-1332	115	19	and	and	CCONJ
dti-1332	115	20	the	the	DET
dti-1332	115	21	other	other	ADJ
dti-1332	115	22	(	(	PUNCT
dti-1332	115	23	sense	sense	NOUN
dti-1332	115	24	strand	strand	NOUN
dti-1332	115	25	)	)	PUNCT
dti-1332	115	26	is	be	AUX
dti-1332	115	27	destroyed	destroy	VERB
dti-1332	115	28	.	.	PUNCT
dti-1332	116	1	risc	risc	PROPN
dti-1332	116	2	further	far	ADV
dti-1332	116	3	guides	guide	VERB
dti-1332	116	4	the	the	DET
dti-1332	116	5	antisense	antisense	NOUN
dti-1332	116	6	strand	strand	NOUN
dti-1332	116	7	to	to	PART
dti-1332	116	8	silence	silence	VERB
dti-1332	116	9	the	the	DET
dti-1332	116	10	targeted	target	VERB
dti-1332	116	11	mrna	mrna	NOUN
dti-1332	116	12	.	.	PUNCT
dti-1332	117	1	this	this	DET
dti-1332	117	2	therapeutic	therapeutic	ADJ
dti-1332	117	3	gene	gene	NOUN
dti-1332	117	4	silencing	silence	VERB
dti-1332	117	5	acts	act	NOUN
dti-1332	117	6	before	before	SCONJ
dti-1332	117	7	the	the	DET
dti-1332	117	8	mrna	mrna	NOUN
dti-1332	117	9	is	be	AUX
dti-1332	117	10	being	be	AUX
dti-1332	117	11	translated	translate	VERB
dti-1332	117	12	into	into	ADP
dti-1332	117	13	protein	protein	NOUN
dti-1332	117	14	(	(	PUNCT
dti-1332	117	15	buckingham	buckingham	PROPN
dti-1332	117	16	et	et	PROPN
dti-1332	117	17	al	al	PROPN
dti-1332	117	18	.	.	PROPN
dti-1332	117	19	2004	2004	NUM
dti-1332	117	20	)	)	PUNCT
dti-1332	117	21	,	,	PUNCT
dti-1332	117	22	thus	thus	ADV
dti-1332	117	23	it	it	PRON
dti-1332	117	24	is	be	AUX
dti-1332	117	25	also	also	ADV
dti-1332	117	26	known	know	VERB
dti-1332	117	27	as	as	ADP
dti-1332	117	28	post	post	ADJ
dti-1332	117	29	-	-	ADJ
dti-1332	117	30	transcriptional	transcriptional	ADJ
dti-1332	117	31	gene	gene	NOUN
dti-1332	117	32	silencing	silence	VERB
dti-1332	117	33	.	.	PUNCT
dti-1332	118	1	a	a	DET
dti-1332	118	2	brief	brief	ADJ
dti-1332	118	3	mechanism	mechanism	NOUN
dti-1332	118	4	of	of	ADP
dti-1332	118	5	sirna	sirna	PROPN
dti-1332	118	6	mediated	mediate	VERB
dti-1332	118	7	gene	gene	NOUN
dti-1332	118	8	silencing	silence	VERB
dti-1332	118	9	is	be	AUX
dti-1332	118	10	explained	explain	VERB
dti-1332	118	11	in	in	ADP
dti-1332	118	12	figure	figure	NOUN
dti-1332	118	13	3	3	NUM
dti-1332	118	14	.	.	PUNCT
dti-1332	118	15	initially	initially	ADV
dti-1332	118	16	,	,	PUNCT
dti-1332	118	17	immunogenicity	immunogenicity	NOUN
dti-1332	118	18	was	be	AUX
dti-1332	118	19	considered	consider	VERB
dti-1332	118	20	one	one	NUM
dti-1332	118	21	of	of	ADP
dti-1332	118	22	the	the	DET
dti-1332	118	23	major	major	ADJ
dti-1332	118	24	concerns	concern	NOUN
dti-1332	118	25	with	with	ADP
dti-1332	118	26	respect	respect	NOUN
dti-1332	118	27	to	to	ADP
dti-1332	118	28	sirnas	sirna	NOUN
dti-1332	118	29	but	but	CCONJ
dti-1332	118	30	it	it	PRON
dti-1332	118	31	was	be	AUX
dti-1332	118	32	later	later	ADV
dti-1332	118	33	elucidated	elucidated	ADJ
dti-1332	118	34	that	that	SCONJ
dti-1332	118	35	sirna	sirna	PROPN
dti-1332	118	36	molecules	molecule	NOUN
dti-1332	118	37	smaller	small	ADJ
dti-1332	118	38	than	than	ADP
dti-1332	118	39	30	30	NUM
dti-1332	118	40	bp	bp	NOUN
dti-1332	118	41	do	do	AUX
dti-1332	118	42	not	not	PART
dti-1332	118	43	cause	cause	VERB
dti-1332	118	44	any	any	DET
dti-1332	118	45	immune	immune	ADJ
dti-1332	118	46	response	response	NOUN
dti-1332	118	47	.	.	PUNCT
dti-1332	119	1	the	the	DET
dti-1332	119	2	major	major	ADJ
dti-1332	119	3	advantage	advantage	NOUN
dti-1332	119	4	of	of	ADP
dti-1332	119	5	using	use	VERB
dti-1332	119	6	sirnas	sirnas	PROPN
dti-1332	119	7	is	be	AUX
dti-1332	119	8	their	their	PRON
dti-1332	119	9	straightforward	straightforward	ADJ
dti-1332	119	10	synthesis	synthesis	NOUN
dti-1332	119	11	that	that	PRON
dti-1332	119	12	does	do	AUX
dti-1332	119	13	not	not	PART
dti-1332	119	14	involve	involve	VERB
dti-1332	119	15	any	any	DET
dti-1332	119	16	complex	complex	ADJ
dti-1332	119	17	purifi	purifi	ADJ
dti-1332	119	18	cation	cation	NOUN
dti-1332	119	19	schemes	scheme	NOUN
dti-1332	119	20	and	and	CCONJ
dti-1332	119	21	a	a	DET
dti-1332	119	22	cellular	cellular	ADJ
dti-1332	119	23	expression	expression	NOUN
dti-1332	119	24	system	system	NOUN
dti-1332	119	25	(	(	PUNCT
dti-1332	119	26	sah	sah	NOUN
dti-1332	119	27	et	et	PROPN
dti-1332	119	28	al	al	PROPN
dti-1332	119	29	.	.	PROPN
dti-1332	119	30	2006	2006	NUM
dti-1332	119	31	)	)	PUNCT
dti-1332	119	32	.	.	PUNCT
dti-1332	120	1	though	though	ADV
dti-1332	120	2	,	,	PUNCT
dti-1332	120	3	sirna	sirna	PROPN
dti-1332	120	4	may	may	AUX
dti-1332	120	5	be	be	AUX
dti-1332	120	6	the	the	DET
dti-1332	120	7	most	most	ADV
dti-1332	120	8	effective	effective	ADJ
dti-1332	120	9	method	method	NOUN
dti-1332	120	10	to	to	PART
dti-1332	120	11	treat	treat	VERB
dti-1332	120	12	the	the	DET
dti-1332	120	13	disease	disease	NOUN
dti-1332	120	14	,	,	PUNCT
dti-1332	120	15	there	there	PRON
dti-1332	120	16	will	will	AUX
dti-1332	120	17	be	be	AUX
dti-1332	120	18	a	a	DET
dti-1332	120	19	problem	problem	NOUN
dti-1332	120	20	with	with	ADP
dti-1332	120	21	down	down	ADP
dti-1332	120	22	regulating	regulate	VERB
dti-1332	120	23	the	the	DET
dti-1332	120	24	gene	gene	NOUN
dti-1332	120	25	due	due	ADP
dti-1332	120	26	to	to	ADP
dti-1332	120	27	its	its	PRON
dti-1332	120	28	inherent	inherent	ADJ
dti-1332	120	29	instability	instability	NOUN
dti-1332	120	30	,	,	PUNCT
dti-1332	120	31	off	off	ADP
dti-1332	120	32	-	-	PUNCT
dti-1332	120	33	target	target	NOUN
dti-1332	120	34	effects	effect	NOUN
dti-1332	120	35	and	and	CCONJ
dti-1332	120	36	lack	lack	NOUN
dti-1332	120	37	of	of	ADP
dti-1332	120	38	effective	effective	ADJ
dti-1332	120	39	delivery	delivery	NOUN
dti-1332	120	40	systems	system	NOUN
dti-1332	120	41	.	.	PUNCT
dti-1332	121	1	shrna	shrna	PROPN
dti-1332	121	2	are	be	AUX
dti-1332	121	3	also	also	ADV
dti-1332	121	4	gaining	gain	VERB
dti-1332	121	5	importance	importance	NOUN
dti-1332	121	6	over	over	ADP
dti-1332	121	7	sirnas	sirna	NOUN
dti-1332	121	8	as	as	SCONJ
dti-1332	121	9	they	they	PRON
dti-1332	121	10	are	be	AUX
dti-1332	121	11	more	more	ADV
dti-1332	121	12	stable	stable	ADJ
dti-1332	121	13	and	and	CCONJ
dti-1332	121	14	are	be	AUX
dti-1332	121	15	expressed	express	VERB
dti-1332	121	16	continuously	continuously	ADV
dti-1332	121	17	via	via	ADP
dti-1332	121	18	a	a	DET
dti-1332	121	19	plasmid	plasmid	NOUN
dti-1332	121	20	or	or	CCONJ
dti-1332	121	21	a	a	DET
dti-1332	121	22	viral	viral	ADJ
dti-1332	121	23	vector	vector	NOUN
dti-1332	121	24	.	.	PUNCT
dti-1332	122	1	they	they	PRON
dti-1332	122	2	are	be	AUX
dti-1332	122	3	more	more	ADV
dti-1332	122	4	promising	promising	ADJ
dti-1332	122	5	showing	show	VERB
dti-1332	122	6	stable	stable	ADJ
dti-1332	122	7	targeted	target	VERB
dti-1332	122	8	gene	gene	NOUN
dti-1332	122	9	silencing	silence	VERB
dti-1332	122	10	(	(	PUNCT
dti-1332	122	11	paddison	paddison	PROPN
dti-1332	122	12	et	et	PROPN
dti-1332	122	13	al	al	PROPN
dti-1332	122	14	.	.	PROPN
dti-1332	122	15	2004	2004	NUM
dti-1332	122	16	)	)	PUNCT
dti-1332	122	17	.	.	PUNCT
dti-1332	123	1	they	they	PRON
dti-1332	123	2	act	act	VERB
dti-1332	123	3	as	as	ADP
dti-1332	123	4	precursors	precursor	NOUN
dti-1332	123	5	to	to	ADP
dti-1332	123	6	sirnas	sirnas	PROPN
dti-1332	123	7	(	(	PUNCT
dti-1332	123	8	brummelkamp	brummelkamp	PROPN
dti-1332	123	9	et	et	PROPN
dti-1332	123	10	al	al	PROPN
dti-1332	123	11	.	.	PROPN
dti-1332	123	12	2002	2002	NUM
dti-1332	123	13	)	)	PUNCT
dti-1332	123	14	and	and	CCONJ
dti-1332	123	15	comprise	comprise	VERB
dti-1332	123	16	of	of	ADP
dti-1332	123	17	a	a	DET
dti-1332	123	18	non	non	ADJ
dti-1332	123	19	-	-	ADJ
dti-1332	123	20	complimentary	complimentary	ADJ
dti-1332	123	21	loop	loop	NOUN
dti-1332	123	22	that	that	PRON
dti-1332	123	23	separates	separate	VERB
dti-1332	123	24	sense	sense	NOUN
dti-1332	123	25	and	and	CCONJ
dti-1332	123	26	the	the	DET
dti-1332	123	27	antisense	antisense	NOUN
dti-1332	123	28	strands	strand	VERB
dti-1332	123	29	.	.	PUNCT
dti-1332	124	1	the	the	DET
dti-1332	124	2	formation	formation	NOUN
dti-1332	124	3	of	of	ADP
dti-1332	124	4	sirna	sirna	PROPN
dti-1332	124	5	from	from	ADP
dti-1332	124	6	shrna	shrna	PROPN
dti-1332	124	7	follows	follow	VERB
dti-1332	124	8	the	the	DET
dti-1332	124	9	same	same	ADJ
dti-1332	124	10	mechanism	mechanism	NOUN
dti-1332	124	11	which	which	PRON
dti-1332	124	12	includes	include	VERB
dti-1332	124	13	dicer	dicer	NOUN
dti-1332	124	14	that	that	PRON
dti-1332	124	15	processes	process	VERB
dti-1332	124	16	the	the	DET
dti-1332	124	17	shrna	shrna	NOUN
dti-1332	124	18	into	into	ADP
dti-1332	124	19	19–21	19–21	NUM
dti-1332	124	20	long	long	ADJ
dti-1332	124	21	nucleotide	nucleotide	NOUN
dti-1332	124	22	base	base	NOUN
dti-1332	124	23	pairs	pair	NOUN
dti-1332	124	24	.	.	PUNCT
dti-1332	125	1	in	in	ADP
dti-1332	125	2	order	order	NOUN
dti-1332	125	3	to	to	PART
dti-1332	125	4	achieve	achieve	VERB
dti-1332	125	5	efficient	efficient	ADJ
dti-1332	125	6	gene	gene	NOUN
dti-1332	125	7	silencing	silencing	NOUN
dti-1332	125	8	,	,	PUNCT
dti-1332	125	9	shrnas	shrna	NOUN
dti-1332	125	10	are	be	AUX
dti-1332	125	11	placed	place	VERB
dti-1332	125	12	under	under	ADP
dti-1332	125	13	the	the	DET
dti-1332	125	14	control	control	NOUN
dti-1332	125	15	of	of	ADP
dti-1332	125	16	polymerase	polymerase	NOUN
dti-1332	125	17	iii	iii	NOUN
dti-1332	125	18	promoter	promoter	NOUN
dti-1332	125	19	,	,	PUNCT
dti-1332	125	20	which	which	PRON
dti-1332	125	21	is	be	AUX
dti-1332	125	22	usually	usually	ADV
dti-1332	125	23	a	a	DET
dti-1332	125	24	u6	u6	ADJ
dti-1332	125	25	small	small	ADJ
dti-1332	125	26	nuclear	nuclear	ADJ
dti-1332	125	27	rna	rna	NOUN
dti-1332	125	28	promoter	promoter	NOUN
dti-1332	125	29	or	or	CCONJ
dti-1332	125	30	rnase	rnase	PROPN
dti-1332	125	31	p	p	PROPN
dti-1332	125	32	h1	h1	PROPN
dti-1332	125	33	subunit	subunit	NOUN
dti-1332	125	34	promoter	promoter	NOUN
dti-1332	125	35	(	(	PUNCT
dti-1332	125	36	rodrigueze	rodrigueze	PROPN
dti-1332	125	37	-	-	PUNCT
dti-1332	125	38	lebron	lebron	PROPN
dti-1332	125	39	and	and	CCONJ
dti-1332	125	40	gonzalezalegre	gonzalezalegre	NOUN
dti-1332	125	41	,	,	PUNCT
dti-1332	125	42	2006	2006	NUM
dti-1332	125	43	)	)	PUNCT
dti-1332	125	44	.	.	PUNCT
dti-1332	126	1	use	use	NOUN
dti-1332	126	2	of	of	ADP
dti-1332	126	3	rnai	rnai	PROPN
dti-1332	126	4	in	in	ADP
dti-1332	126	5	in	in	ADP
dti-1332	126	6	vitro	vitro	X
dti-1332	126	7	studies	study	NOUN
dti-1332	126	8	dealing	deal	VERB
dti-1332	126	9	with	with	ADP
dti-1332	126	10	polyglutamine	polyglutamine	NOUN
dti-1332	126	11	diseases	disease	NOUN
dti-1332	126	12	shows	show	VERB
dti-1332	126	13	a	a	DET
dti-1332	126	14	promising	promising	ADJ
dti-1332	126	15	therapy	therapy	NOUN
dti-1332	126	16	.	.	PUNCT
dti-1332	127	1	effi	effi	PROPN
dti-1332	127	2	cient	cient	PROPN
dti-1332	127	3	,	,	PUNCT
dti-1332	127	4	sequence	sequence	NOUN
dti-1332	127	5	specifi	specifi	PROPN
dti-1332	127	6	c	c	PROPN
dti-1332	127	7	sirnas	sirnas	PROPN
dti-1332	127	8	have	have	AUX
dti-1332	127	9	been	be	AUX
dti-1332	127	10	table	table	NOUN
dti-1332	127	11	2	2	NUM
dti-1332	127	12	.	.	PUNCT
dti-1332	127	13	different	different	ADJ
dti-1332	127	14	drugs	drug	NOUN
dti-1332	127	15	/	/	SYM
dti-1332	127	16	chemicals	chemical	NOUN
dti-1332	127	17	available	available	ADJ
dti-1332	127	18	for	for	ADP
dti-1332	127	19	the	the	DET
dti-1332	127	20	treatment	treatment	NOUN
dti-1332	127	21	of	of	ADP
dti-1332	127	22	ataxic	ataxic	ADJ
dti-1332	127	23	symptoms	symptom	NOUN
dti-1332	127	24	.	.	PUNCT
dti-1332	128	1	drugs	drug	NOUN
dti-1332	128	2	/	/	SYM
dti-1332	128	3	chemicals	chemical	NOUN
dti-1332	128	4	treatment	treatment	NOUN
dti-1332	128	5	effect	effect	NOUN
dti-1332	128	6	references	reference	NOUN
dti-1332	128	7	acetazolamide	acetazolamide	ADV
dti-1332	128	8	reduced	reduce	VERB
dti-1332	128	9	symptoms	symptom	NOUN
dti-1332	128	10	in	in	ADP
dti-1332	128	11	sca	sca	PROPN
dti-1332	128	12	6	6	NUM
dti-1332	128	13	yabe	yabe	NOUN
dti-1332	128	14	et	et	PROPN
dti-1332	128	15	al	al	PROPN
dti-1332	128	16	.	.	PROPN
dti-1332	128	17	2001	2001	NUM
dti-1332	128	18	dopaminergic	dopaminergic	ADJ
dti-1332	128	19	and	and	CCONJ
dti-1332	128	20	anticholinergic	anticholinergic	ADJ
dti-1332	128	21	drugs	drug	NOUN
dti-1332	128	22	alleviate	alleviate	VERB
dti-1332	128	23	tremor	tremor	NOUN
dti-1332	128	24	,	,	PUNCT
dti-1332	128	25	bradykinesia	bradykinesia	NOUN
dti-1332	128	26	or	or	CCONJ
dti-1332	128	27	dystonia	dystonia	NOUN
dti-1332	128	28	in	in	ADP
dti-1332	128	29	sca	sca	PROPN
dti-1332	128	30	2	2	NUM
dti-1332	128	31	buhmann	buhmann	NOUN
dti-1332	128	32	et	et	PROPN
dti-1332	128	33	al	al	PROPN
dti-1332	128	34	.	.	PROPN
dti-1332	128	35	2003	2003	NUM
dti-1332	128	36	;	;	PUNCT
dti-1332	128	37	nandagopal	nandagopal	PROPN
dti-1332	128	38	and	and	CCONJ
dti-1332	128	39	moorthy	moorthy	PROPN
dti-1332	128	40	2004	2004	NUM
dti-1332	128	41	baclofen	baclofen	PROPN
dti-1332	128	42	,	,	PUNCT
dti-1332	128	43	tizanadine	tizanadine	NOUN
dti-1332	128	44	or	or	CCONJ
dti-1332	128	45	mimentine	mimentine	NOUN
dti-1332	128	46	reduce	reduce	VERB
dti-1332	128	47	spasticity	spasticity	NOUN
dti-1332	128	48	botulinum	botulinum	ADJ
dti-1332	128	49	toxin	toxin	NOUN
dti-1332	128	50	treat	treat	NOUN
dti-1332	128	51	dystonia	dystonia	NOUN
dti-1332	128	52	and	and	CCONJ
dti-1332	128	53	spasticity	spasticity	NOUN
dti-1332	128	54	benzodiazepines	benzodiazepine	NOUN
dti-1332	128	55	treats	treat	VERB
dti-1332	128	56	tremors	tremor	NOUN
dti-1332	128	57	pirker	pirker	NOUN
dti-1332	128	58	et	et	PROPN
dti-1332	128	59	al	al	PROPN
dti-1332	128	60	.	.	PROPN
dti-1332	128	61	2003	2003	NUM
dti-1332	128	62	magnesium	magnesium	NOUN
dti-1332	128	63	,	,	PUNCT
dti-1332	128	64	chinine	chinine	NOUN
dti-1332	128	65	or	or	CCONJ
dti-1332	128	66	mexiletine	mexiletine	NOUN
dti-1332	128	67	treats	treat	NOUN
dti-1332	128	68	muscle	muscle	NOUN
dti-1332	128	69	cramps	cramp	NOUN
dti-1332	128	70	in	in	ADP
dti-1332	128	71	sca	sca	PROPN
dti-1332	128	72	2	2	NUM
dti-1332	128	73	,	,	PUNCT
dti-1332	128	74	3	3	NUM
dti-1332	128	75	,	,	PUNCT
dti-1332	128	76	7	7	NUM
dti-1332	128	77	and	and	CCONJ
dti-1332	128	78	drpla	drpla	ADJ
dti-1332	128	79	gabapentine	gabapentine	NOUN
dti-1332	128	80	reduce	reduce	VERB
dti-1332	128	81	cerebellar	cerebellar	ADJ
dti-1332	128	82	ataxic	ataxic	ADJ
dti-1332	128	83	symptoms	symptom	NOUN
dti-1332	128	84	gazulla	gazulla	VERB
dti-1332	128	85	et	et	NOUN
dti-1332	128	86	al	al	PROPN
dti-1332	128	87	.	.	PROPN
dti-1332	128	88	2004	2004	NUM
dti-1332	128	89	107	107	NUM
dti-1332	128	90	recent	recent	ADJ
dti-1332	128	91	advancements	advancement	NOUN
dti-1332	128	92	in	in	ADP
dti-1332	128	93	targeted	target	VERB
dti-1332	128	94	delivery	delivery	NOUN
dti-1332	128	95	of	of	ADP
dti-1332	128	96	therapeutic	therapeutic	ADJ
dti-1332	128	97	molecules	molecule	NOUN
dti-1332	128	98	drug	drug	NOUN
dti-1332	128	99	target	target	NOUN
dti-1332	128	100	insights	insight	NOUN
dti-1332	128	101	2008:3	2008:3	NUM
dti-1332	128	102	synthesized	synthesize	VERB
dti-1332	128	103	to	to	PART
dti-1332	128	104	target	target	VERB
dti-1332	128	105	the	the	DET
dti-1332	128	106	mutant	mutant	ADJ
dti-1332	128	107	gene	gene	NOUN
dti-1332	128	108	containing	contain	VERB
dti-1332	128	109	cag	cag	PROPN
dti-1332	128	110	repeat	repeat	NOUN
dti-1332	128	111	expansion	expansion	NOUN
dti-1332	128	112	or	or	CCONJ
dti-1332	128	113	its	its	PRON
dti-1332	128	114	adjacent	adjacent	ADJ
dti-1332	128	115	gene	gene	NOUN
dti-1332	128	116	sequences	sequence	NOUN
dti-1332	128	117	(	(	PUNCT
dti-1332	128	118	caplen	caplen	VERB
dti-1332	128	119	et	et	PROPN
dti-1332	128	120	al	al	PROPN
dti-1332	128	121	.	.	PROPN
dti-1332	128	122	2002	2002	NUM
dti-1332	128	123	;	;	PUNCT
dti-1332	128	124	miller	miller	PROPN
dti-1332	128	125	et	et	PROPN
dti-1332	128	126	al	al	PROPN
dti-1332	128	127	.	.	PROPN
dti-1332	128	128	2003	2003	NUM
dti-1332	128	129	)	)	PUNCT
dti-1332	128	130	.	.	PUNCT
dti-1332	129	1	targeting	target	VERB
dti-1332	129	2	directly	directly	ADV
dti-1332	129	3	to	to	ADP
dti-1332	129	4	cag	cag	PROPN
dti-1332	129	5	repeats	repeat	NOUN
dti-1332	129	6	may	may	AUX
dti-1332	129	7	set	set	VERB
dti-1332	129	8	an	an	DET
dti-1332	129	9	offsite	offsite	ADJ
dti-1332	129	10	suppression	suppression	NOUN
dti-1332	129	11	of	of	ADP
dti-1332	129	12	normal	normal	ADJ
dti-1332	129	13	genes	gene	NOUN
dti-1332	129	14	or	or	CCONJ
dti-1332	129	15	other	other	ADJ
dti-1332	129	16	genes	gene	NOUN
dti-1332	129	17	containing	contain	VERB
dti-1332	129	18	cag	cag	PROPN
dti-1332	129	19	repeats	repeat	NOUN
dti-1332	129	20	that	that	PRON
dti-1332	129	21	may	may	AUX
dti-1332	129	22	have	have	VERB
dti-1332	129	23	some	some	DET
dti-1332	129	24	important	important	ADJ
dti-1332	129	25	biological	biological	ADJ
dti-1332	129	26	function	function	NOUN
dti-1332	129	27	.	.	PUNCT
dti-1332	130	1	such	such	ADJ
dti-1332	130	2	sirnas	sirna	NOUN
dti-1332	130	3	have	have	AUX
dti-1332	130	4	been	be	AUX
dti-1332	130	5	designed	design	VERB
dti-1332	130	6	and	and	CCONJ
dti-1332	130	7	can	can	AUX
dti-1332	130	8	carry	carry	VERB
dti-1332	130	9	out	out	ADP
dti-1332	130	10	allele	allele	PROPN
dti-1332	130	11	-	-	PUNCT
dti-1332	130	12	specifi	specifi	PROPN
dti-1332	130	13	c	c	PROPN
dti-1332	130	14	silencing	silencing	NOUN
dti-1332	130	15	of	of	ADP
dti-1332	130	16	the	the	DET
dti-1332	130	17	diseased	diseased	ADJ
dti-1332	130	18	gene	gene	NOUN
dti-1332	130	19	without	without	ADP
dti-1332	130	20	affecting	affect	VERB
dti-1332	130	21	its	its	PRON
dti-1332	130	22	normal	normal	ADJ
dti-1332	130	23	counterpart	counterpart	NOUN
dti-1332	130	24	that	that	PRON
dti-1332	130	25	is	be	AUX
dti-1332	130	26	,	,	PUNCT
dti-1332	130	27	it	it	PRON
dti-1332	130	28	can	can	AUX
dti-1332	130	29	target	target	VERB
dti-1332	130	30	the	the	DET
dti-1332	130	31	mutant	mutant	ADJ
dti-1332	130	32	gene	gene	NOUN
dti-1332	130	33	that	that	PRON
dti-1332	130	34	differs	differ	VERB
dti-1332	130	35	from	from	ADP
dti-1332	130	36	normal	normal	ADJ
dti-1332	130	37	gene	gene	NOUN
dti-1332	130	38	by	by	ADP
dti-1332	130	39	only	only	ADV
dti-1332	130	40	one	one	NUM
dti-1332	130	41	nucleotide	nucleotide	NOUN
dti-1332	130	42	(	(	PUNCT
dti-1332	130	43	schwarz	schwarz	NOUN
dti-1332	130	44	et	et	PROPN
dti-1332	130	45	al	al	PROPN
dti-1332	130	46	.	.	PROPN
dti-1332	130	47	2006	2006	NUM
dti-1332	130	48	)	)	PUNCT
dti-1332	130	49	.	.	PUNCT
dti-1332	131	1	such	such	DET
dti-1332	131	2	a	a	DET
dti-1332	131	3	stringent	stringent	ADJ
dti-1332	131	4	scheme	scheme	NOUN
dti-1332	131	5	has	have	AUX
dti-1332	131	6	already	already	ADV
dti-1332	131	7	been	be	AUX
dti-1332	131	8	developed	develop	VERB
dti-1332	131	9	for	for	ADP
dti-1332	131	10	several	several	ADJ
dti-1332	131	11	neurodegenerative	neurodegenerative	ADJ
dti-1332	131	12	diseases	disease	NOUN
dti-1332	131	13	including	include	VERB
dti-1332	131	14	mjd	mjd	PROPN
dti-1332	131	15	(	(	PUNCT
dti-1332	131	16	machado	machado	PROPN
dti-1332	131	17	joseph	joseph	PROPN
dti-1332	131	18	disease	disease	PROPN
dti-1332	131	19	or	or	CCONJ
dti-1332	131	20	sca3	sca3	PROPN
dti-1332	131	21	)	)	PUNCT
dti-1332	131	22	wherein	wherein	SCONJ
dti-1332	131	23	the	the	DET
dti-1332	131	24	targeted	target	VERB
dti-1332	131	25	region	region	NOUN
dti-1332	131	26	is	be	AUX
dti-1332	131	27	the	the	DET
dti-1332	131	28	snp	snp	ADJ
dti-1332	131	29	(	(	PUNCT
dti-1332	131	30	single	single	ADJ
dti-1332	131	31	nucleotide	nucleotide	ADJ
dti-1332	131	32	polymorphism	polymorphism	NOUN
dti-1332	131	33	)	)	PUNCT
dti-1332	131	34	linked	link	VERB
dti-1332	131	35	to	to	ADP
dti-1332	131	36	the	the	DET
dti-1332	131	37	mutation	mutation	NOUN
dti-1332	131	38	site	site	NOUN
dti-1332	131	39	.	.	PUNCT
dti-1332	132	1	this	this	DET
dti-1332	132	2	achievement	achievement	NOUN
dti-1332	132	3	in	in	ADP
dti-1332	132	4	rnai	rnai	PROPN
dti-1332	132	5	research	research	PROPN
dti-1332	132	6	has	have	AUX
dti-1332	132	7	given	give	VERB
dti-1332	132	8	a	a	DET
dti-1332	132	9	new	new	ADJ
dti-1332	132	10	outlook	outlook	NOUN
dti-1332	132	11	to	to	ADP
dti-1332	132	12	the	the	DET
dti-1332	132	13	treatment	treatment	NOUN
dti-1332	132	14	of	of	ADP
dti-1332	132	15	neurodegenerative	neurodegenerative	ADJ
dti-1332	132	16	diseases	disease	NOUN
dti-1332	132	17	involving	involve	VERB
dti-1332	132	18	expansions	expansion	NOUN
dti-1332	132	19	,	,	PUNCT
dti-1332	132	20	missense	missense	NOUN
dti-1332	132	21	mutations	mutation	NOUN
dti-1332	132	22	like	like	ADP
dti-1332	132	23	in	in	ADP
dti-1332	132	24	figure	figure	NOUN
dti-1332	132	25	3	3	NUM
dti-1332	132	26	.	.	PUNCT
dti-1332	132	27	mechanism	mechanism	NOUN
dti-1332	132	28	of	of	ADP
dti-1332	132	29	rnai	rnai	PROPN
dti-1332	132	30	:	:	PUNCT
dti-1332	132	31	step	step	NOUN
dti-1332	132	32	1	1	NUM
dti-1332	132	33	–	–	PUNCT
dti-1332	132	34	digestion	digestion	NOUN
dti-1332	132	35	of	of	ADP
dti-1332	132	36	dsrna	dsrna	NOUN
dti-1332	132	37	by	by	ADP
dti-1332	132	38	dicer	dicer	NOUN
dti-1332	132	39	,	,	PUNCT
dti-1332	132	40	step	step	NOUN
dti-1332	132	41	2	2	NUM
dti-1332	132	42	–	–	PUNCT
dti-1332	132	43	unwinding	unwind	VERB
dti-1332	132	44	of	of	ADP
dti-1332	132	45	formed	form	VERB
dti-1332	132	46	sirna	sirna	PROPN
dti-1332	132	47	to	to	PART
dti-1332	132	48	which	which	PRON
dti-1332	132	49	a	a	DET
dti-1332	132	50	protein	protein	NOUN
dti-1332	132	51	complex	complex	NOUN
dti-1332	132	52	(	(	PUNCT
dti-1332	132	53	risc	risc	PROPN
dti-1332	132	54	)	)	PUNCT
dti-1332	132	55	attaches	attach	VERB
dti-1332	132	56	,	,	PUNCT
dti-1332	132	57	step	step	NOUN
dti-1332	132	58	3	3	NUM
dti-1332	132	59	–	–	PUNCT
dti-1332	132	60	binding	bind	VERB
dti-1332	132	61	of	of	ADP
dti-1332	132	62	risc	risc	PROPN
dti-1332	132	63	,	,	PUNCT
dti-1332	132	64	directs	direct	VERB
dti-1332	132	65	the	the	DET
dti-1332	132	66	antisense	antisense	NOUN
dti-1332	132	67	strand	strand	NOUN
dti-1332	132	68	of	of	ADP
dti-1332	132	69	sirna	sirna	PROPN
dti-1332	132	70	towards	towards	ADP
dti-1332	132	71	target	target	PROPN
dti-1332	132	72	mrna	mrna	PROPN
dti-1332	132	73	,	,	PUNCT
dti-1332	132	74	step	step	NOUN
dti-1332	132	75	4	4	NUM
dti-1332	132	76	–	–	PUNCT
dti-1332	132	77	degradation	degradation	NOUN
dti-1332	132	78	of	of	ADP
dti-1332	132	79	the	the	DET
dti-1332	132	80	target	target	NOUN
dti-1332	132	81	mrna	mrna	PROPN
dti-1332	132	82	.	.	PUNCT
dti-1332	133	1	108	108	NUM
dti-1332	133	2	prakash	prakash	PROPN
dti-1332	133	3	and	and	CCONJ
dti-1332	133	4	malhotra	malhotra	PROPN
dti-1332	133	5	drug	drug	PROPN
dti-1332	133	6	target	target	NOUN
dti-1332	133	7	insights	insight	VERB
dti-1332	133	8	2008:3	2008:3	NUM
dti-1332	133	9	case	case	NOUN
dti-1332	133	10	of	of	ADP
dti-1332	133	11	sod	sod	NOUN
dti-1332	133	12	in	in	ADP
dti-1332	133	13	amylotrophic	amylotrophic	ADJ
dti-1332	133	14	lateral	lateral	ADJ
dti-1332	133	15	sclerosis	sclerosis	NOUN
dti-1332	133	16	(	(	PUNCT
dti-1332	133	17	ding	ding	NOUN
dti-1332	133	18	et	et	PROPN
dti-1332	133	19	al	al	PROPN
dti-1332	133	20	.	.	PROPN
dti-1332	133	21	2003	2003	NUM
dti-1332	133	22	)	)	PUNCT
dti-1332	133	23	,	,	PUNCT
dti-1332	133	24	tau	tau	PROPN
dti-1332	133	25	in	in	ADP
dti-1332	133	26	frontotemporal	frontotemporal	ADJ
dti-1332	133	27	dementia	dementia	NOUN
dti-1332	133	28	(	(	PUNCT
dti-1332	133	29	miller	miller	PROPN
dti-1332	133	30	et	et	PROPN
dti-1332	133	31	al	al	PROPN
dti-1332	133	32	.	.	PROPN
dti-1332	133	33	2003	2003	NUM
dti-1332	133	34	)	)	PUNCT
dti-1332	133	35	,	,	PUNCT
dti-1332	133	36	amyloid	amyloid	NOUN
dti-1332	133	37	precursor	precursor	NOUN
dti-1332	133	38	protein	protein	NOUN
dti-1332	133	39	(	(	PUNCT
dti-1332	133	40	app	app	NOUN
dti-1332	133	41	)	)	PUNCT
dti-1332	133	42	in	in	ADP
dti-1332	133	43	alzheimer	alzheimer	PROPN
dti-1332	133	44	’s	’s	PART
dti-1332	133	45	disease	disease	NOUN
dti-1332	133	46	(	(	PUNCT
dti-1332	133	47	miller	miller	PROPN
dti-1332	133	48	et	et	PROPN
dti-1332	133	49	al	al	PROPN
dti-1332	133	50	.	.	PROPN
dti-1332	133	51	2004	2004	NUM
dti-1332	133	52	)	)	PUNCT
dti-1332	133	53	and	and	CCONJ
dti-1332	133	54	deletion	deletion	NOUN
dti-1332	133	55	in	in	ADP
dti-1332	133	56	the	the	DET
dti-1332	133	57	case	case	NOUN
dti-1332	133	58	of	of	ADP
dti-1332	133	59	dyt1	dyt1	NOUN
dti-1332	133	60	involving	involve	VERB
dti-1332	133	61	3	3	NUM
dti-1332	133	62	base	base	NOUN
dti-1332	133	63	pair	pair	NOUN
dti-1332	133	64	deletion	deletion	NOUN
dti-1332	133	65	(	(	PUNCT
dti-1332	133	66	gag	gag	NOUN
dti-1332	133	67	)	)	PUNCT
dti-1332	133	68	in	in	ADP
dti-1332	133	69	coding	code	VERB
dti-1332	133	70	region	region	NOUN
dti-1332	133	71	of	of	ADP
dti-1332	133	72	tor1a	tor1a	NOUN
dti-1332	133	73	gene	gene	NOUN
dti-1332	133	74	.	.	PUNCT
dti-1332	134	1	the	the	DET
dti-1332	134	2	allele	allele	PROPN
dti-1332	134	3	-	-	PUNCT
dti-1332	134	4	specifi	specifi	PROPN
dti-1332	134	5	c	c	PROPN
dti-1332	134	6	gene	gene	NOUN
dti-1332	134	7	silencing	silence	VERB
dti-1332	134	8	suppresses	suppress	VERB
dti-1332	134	9	the	the	DET
dti-1332	134	10	expression	expression	NOUN
dti-1332	134	11	of	of	ADP
dti-1332	134	12	mutant	mutant	NOUN
dti-1332	134	13	torsin	torsin	VERB
dti-1332	134	14	a	a	DET
dti-1332	134	15	protein	protein	NOUN
dti-1332	134	16	and	and	CCONJ
dti-1332	134	17	allows	allow	VERB
dti-1332	134	18	continuous	continuous	ADJ
dti-1332	134	19	expression	expression	NOUN
dti-1332	134	20	of	of	ADP
dti-1332	134	21	the	the	DET
dti-1332	134	22	wild	wild	ADJ
dti-1332	134	23	type	type	NOUN
dti-1332	134	24	protein	protein	NOUN
dti-1332	134	25	(	(	PUNCT
dti-1332	134	26	gonzalez	gonzalez	PROPN
dti-1332	134	27	-	-	PUNCT
dti-1332	134	28	alegre	alegre	PROPN
dti-1332	134	29	,	,	PUNCT
dti-1332	134	30	2003	2003	NUM
dti-1332	134	31	)	)	PUNCT
dti-1332	134	32	.	.	PUNCT
dti-1332	135	1	rnai	rnai	PROPN
dti-1332	135	2	with	with	ADP
dti-1332	135	3	its	its	PRON
dti-1332	135	4	promising	promising	ADJ
dti-1332	135	5	results	result	NOUN
dti-1332	135	6	on	on	ADP
dti-1332	135	7	primary	primary	ADJ
dti-1332	135	8	neuronal	neuronal	ADJ
dti-1332	135	9	cells	cell	NOUN
dti-1332	135	10	(	(	PUNCT
dti-1332	135	11	krichevsky	krichevsky	NOUN
dti-1332	135	12	,	,	PUNCT
dti-1332	135	13	2002	2002	NUM
dti-1332	135	14	)	)	PUNCT
dti-1332	135	15	,	,	PUNCT
dti-1332	135	16	mouse	mouse	NOUN
dti-1332	135	17	neuroblastoma	neuroblastoma	ADJ
dti-1332	135	18	cells	cell	NOUN
dti-1332	135	19	(	(	PUNCT
dti-1332	135	20	gan	gan	VERB
dti-1332	135	21	et	et	PROPN
dti-1332	135	22	al	al	PROPN
dti-1332	135	23	.	.	PROPN
dti-1332	135	24	2002	2002	NUM
dti-1332	135	25	)	)	PUNCT
dti-1332	135	26	,	,	PUNCT
dti-1332	135	27	in	in	ADP
dti-1332	135	28	vitro	vitro	X
dti-1332	135	29	for	for	ADP
dti-1332	135	30	treatment	treatment	NOUN
dti-1332	135	31	of	of	ADP
dti-1332	135	32	neurological	neurological	ADJ
dti-1332	135	33	diseases	disease	NOUN
dti-1332	135	34	has	have	AUX
dti-1332	135	35	led	lead	VERB
dti-1332	135	36	a	a	DET
dti-1332	135	37	foundation	foundation	NOUN
dti-1332	135	38	for	for	ADP
dti-1332	135	39	gene	gene	NOUN
dti-1332	135	40	therapy	therapy	NOUN
dti-1332	135	41	experiments	experiment	NOUN
dti-1332	135	42	,	,	PUNCT
dti-1332	135	43	paving	pave	VERB
dti-1332	135	44	its	its	PRON
dti-1332	135	45	way	way	NOUN
dti-1332	135	46	towards	towards	ADP
dti-1332	135	47	in	in	ADP
dti-1332	135	48	vivo	vivo	ADJ
dti-1332	135	49	experiments	experiment	NOUN
dti-1332	135	50	.	.	PUNCT
dti-1332	136	1	successful	successful	ADJ
dti-1332	136	2	animal	animal	NOUN
dti-1332	136	3	model	model	NOUN
dti-1332	136	4	of	of	ADP
dti-1332	136	5	transgenic	transgenic	NOUN
dti-1332	136	6	mice	mouse	NOUN
dti-1332	136	7	expressing	express	VERB
dti-1332	136	8	human	human	ADJ
dti-1332	136	9	sca1	sca1	NOUN
dti-1332	136	10	gene	gene	NOUN
dti-1332	136	11	has	have	AUX
dti-1332	136	12	been	be	AUX
dti-1332	136	13	established	establish	VERB
dti-1332	136	14	,	,	PUNCT
dti-1332	136	15	the	the	DET
dti-1332	136	16	study	study	NOUN
dti-1332	136	17	confi	confi	VERB
dti-1332	136	18	rms	rm	NOUN
dti-1332	136	19	that	that	PRON
dti-1332	136	20	extended	extend	VERB
dti-1332	136	21	cag	cag	PROPN
dti-1332	136	22	repeats	repeat	NOUN
dti-1332	136	23	expressed	express	VERB
dti-1332	136	24	in	in	ADP
dti-1332	136	25	purkinje	purkinje	PROPN
dti-1332	136	26	cells	cell	NOUN
dti-1332	136	27	produce	produce	VERB
dti-1332	136	28	degeneration	degeneration	NOUN
dti-1332	136	29	of	of	ADP
dti-1332	136	30	neurons	neuron	NOUN
dti-1332	136	31	causing	cause	VERB
dti-1332	136	32	ataxia	ataxia	NOUN
dti-1332	136	33	(	(	PUNCT
dti-1332	136	34	burright	burright	PROPN
dti-1332	136	35	et	et	PROPN
dti-1332	136	36	al	al	PROPN
dti-1332	136	37	.	.	PROPN
dti-1332	136	38	1995	1995	NUM
dti-1332	136	39	)	)	PUNCT
dti-1332	136	40	.	.	PUNCT
dti-1332	137	1	animal	animal	NOUN
dti-1332	137	2	model	model	NOUN
dti-1332	137	3	studies	study	NOUN
dti-1332	137	4	on	on	ADP
dti-1332	137	5	transgenic	transgenic	NOUN
dti-1332	137	6	mice	mouse	NOUN
dti-1332	137	7	were	be	AUX
dti-1332	137	8	conducted	conduct	VERB
dti-1332	137	9	by	by	ADP
dti-1332	137	10	xia	xia	PROPN
dti-1332	137	11	et	et	PROPN
dti-1332	137	12	al	al	PROPN
dti-1332	137	13	.	.	PUNCT
dti-1332	138	1	they	they	PRON
dti-1332	138	2	delivered	deliver	VERB
dti-1332	138	3	recombinant	recombinant	ADJ
dti-1332	138	4	adenoassociated	adenoassociated	ADJ
dti-1332	138	5	virus	virus	NOUN
dti-1332	138	6	expressing	express	VERB
dti-1332	138	7	sirna	sirna	PROPN
dti-1332	138	8	against	against	ADP
dti-1332	138	9	mutant	mutant	NOUN
dti-1332	138	10	ataxin-1	ataxin-1	NUM
dti-1332	138	11	allele	allele	NOUN
dti-1332	138	12	that	that	PRON
dti-1332	138	13	code	code	VERB
dti-1332	138	14	for	for	ADP
dti-1332	138	15	mutant	mutant	ADJ
dti-1332	138	16	ataxin-1	ataxin-1	NUM
dti-1332	138	17	inclusion	inclusion	NOUN
dti-1332	138	18	proteins	protein	NOUN
dti-1332	138	19	in	in	ADP
dti-1332	138	20	sca1	sca1	NOUN
dti-1332	138	21	mice	mice	NOUN
dti-1332	138	22	model	model	NOUN
dti-1332	138	23	.	.	PUNCT
dti-1332	139	1	the	the	DET
dti-1332	139	2	physiological	physiological	ADJ
dti-1332	139	3	and	and	CCONJ
dti-1332	139	4	morphological	morphological	ADJ
dti-1332	139	5	examination	examination	NOUN
dti-1332	139	6	of	of	ADP
dti-1332	139	7	the	the	DET
dti-1332	139	8	mice	mouse	NOUN
dti-1332	139	9	revealed	reveal	VERB
dti-1332	139	10	restoration	restoration	NOUN
dti-1332	139	11	and	and	CCONJ
dti-1332	139	12	improvement	improvement	NOUN
dti-1332	139	13	of	of	ADP
dti-1332	139	14	the	the	DET
dti-1332	139	15	cerebellum	cerebellum	ADJ
dti-1332	139	16	and	and	CCONJ
dti-1332	139	17	motor	motor	NOUN
dti-1332	139	18	coordination	coordination	NOUN
dti-1332	139	19	in	in	ADP
dti-1332	139	20	mice	mouse	NOUN
dti-1332	139	21	(	(	PUNCT
dti-1332	139	22	xia	xia	PROPN
dti-1332	139	23	et	et	PROPN
dti-1332	139	24	al	al	PROPN
dti-1332	139	25	.	.	PROPN
dti-1332	139	26	2004	2004	NUM
dti-1332	139	27	)	)	PUNCT
dti-1332	139	28	.	.	PUNCT
dti-1332	140	1	sirna	sirna	PROPN
dti-1332	140	2	specifi	specifi	PROPN
dti-1332	140	3	city	city	PROPN
dti-1332	140	4	specifi	specifi	PROPN
dti-1332	140	5	city	city	PROPN
dti-1332	140	6	of	of	ADP
dti-1332	140	7	the	the	DET
dti-1332	140	8	synthesized	synthesize	VERB
dti-1332	140	9	sirna	sirna	PROPN
dti-1332	140	10	or	or	CCONJ
dti-1332	140	11	shrna	shrna	NOUN
dti-1332	140	12	is	be	AUX
dti-1332	140	13	another	another	DET
dti-1332	140	14	important	important	ADJ
dti-1332	140	15	issue	issue	NOUN
dti-1332	140	16	that	that	PRON
dti-1332	140	17	may	may	AUX
dti-1332	140	18	evade	evade	VERB
dti-1332	140	19	off	off	ADP
dti-1332	140	20	-	-	PUNCT
dti-1332	140	21	target	target	NOUN
dti-1332	140	22	effects	effect	NOUN
dti-1332	140	23	by	by	ADP
dti-1332	140	24	preventing	prevent	VERB
dti-1332	140	25	them	they	PRON
dti-1332	140	26	to	to	PART
dti-1332	140	27	attack	attack	VERB
dti-1332	140	28	on	on	ADP
dti-1332	140	29	unintended	unintended	ADJ
dti-1332	140	30	target	target	NOUN
dti-1332	140	31	sites	site	NOUN
dti-1332	140	32	.	.	PUNCT
dti-1332	141	1	for	for	ADP
dti-1332	141	2	gene	gene	NOUN
dti-1332	141	3	knock	knock	VERB
dti-1332	141	4	down	down	ADP
dti-1332	141	5	experiments	experiment	NOUN
dti-1332	141	6	,	,	PUNCT
dti-1332	141	7	using	use	VERB
dti-1332	141	8	multiple	multiple	ADJ
dti-1332	141	9	short	short	ADJ
dti-1332	141	10	interfering	interfere	VERB
dti-1332	141	11	rnas	rna	NOUN
dti-1332	141	12	would	would	AUX
dti-1332	141	13	be	be	AUX
dti-1332	141	14	very	very	ADV
dti-1332	141	15	cumbersome	cumbersome	ADJ
dti-1332	141	16	and	and	CCONJ
dti-1332	141	17	it	it	PRON
dti-1332	141	18	would	would	AUX
dti-1332	141	19	become	become	VERB
dti-1332	141	20	diffi	diffi	ADJ
dti-1332	141	21	cult	cult	NOUN
dti-1332	141	22	to	to	PART
dti-1332	141	23	predict	predict	VERB
dti-1332	141	24	the	the	DET
dti-1332	141	25	side	side	NOUN
dti-1332	141	26	effects	effect	NOUN
dti-1332	141	27	based	base	VERB
dti-1332	141	28	on	on	ADP
dti-1332	141	29	offtargeting	offtargeting	PROPN
dti-1332	141	30	.	.	PUNCT
dti-1332	142	1	certain	certain	ADJ
dti-1332	142	2	rule	rule	NOUN
dti-1332	142	3	sets	set	NOUN
dti-1332	142	4	like	like	ADP
dti-1332	142	5	reynolds	reynolds	PROPN
dti-1332	142	6	(	(	PUNCT
dti-1332	142	7	reynolds	reynolds	PROPN
dti-1332	142	8	et	et	PROPN
dti-1332	142	9	al	al	PROPN
dti-1332	142	10	.	.	PROPN
dti-1332	142	11	2004	2004	NUM
dti-1332	142	12	)	)	PUNCT
dti-1332	142	13	,	,	PUNCT
dti-1332	142	14	tuschl	tuschl	NOUN
dti-1332	142	15	(	(	PUNCT
dti-1332	142	16	tuschl	tuschl	NOUN
dti-1332	142	17	et	et	PROPN
dti-1332	142	18	al	al	PROPN
dti-1332	142	19	.	.	PROPN
dti-1332	142	20	2001	2001	NUM
dti-1332	142	21	)	)	PUNCT
dti-1332	142	22	,	,	PUNCT
dti-1332	142	23	ui	ui	NOUN
dti-1332	142	24	-	-	PUNCT
dti-1332	142	25	tei	tei	NOUN
dti-1332	142	26	(	(	PUNCT
dti-1332	142	27	ui	ui	NOUN
dti-1332	142	28	-	-	NOUN
dti-1332	142	29	tei	tei	NOUN
dti-1332	142	30	et	et	PROPN
dti-1332	142	31	al	al	PROPN
dti-1332	142	32	.	.	PROPN
dti-1332	142	33	2004	2004	NUM
dti-1332	142	34	)	)	PUNCT
dti-1332	142	35	etc	etc	X
dti-1332	142	36	.	.	X
dti-1332	142	37	have	have	AUX
dti-1332	142	38	been	be	AUX
dti-1332	142	39	used	use	VERB
dti-1332	142	40	which	which	DET
dti-1332	142	41	fi	fi	NOUN
dti-1332	142	42	lter	lter	NOUN
dti-1332	142	43	out	out	ADP
dti-1332	142	44	the	the	DET
dti-1332	142	45	ineffi	ineffi	PROPN
dti-1332	142	46	cient	cient	NOUN
dti-1332	142	47	candidates	candidate	NOUN
dti-1332	142	48	,	,	PUNCT
dti-1332	142	49	so	so	SCONJ
dti-1332	142	50	that	that	SCONJ
dti-1332	142	51	the	the	DET
dti-1332	142	52	minimal	minimal	ADJ
dti-1332	142	53	number	number	NOUN
dti-1332	142	54	of	of	ADP
dti-1332	142	55	sirnas	sirna	NOUN
dti-1332	142	56	obtained	obtain	VERB
dti-1332	142	57	may	may	AUX
dti-1332	142	58	not	not	PART
dti-1332	142	59	meddle	meddle	VERB
dti-1332	142	60	with	with	ADP
dti-1332	142	61	any	any	DET
dti-1332	142	62	unintended	unintended	ADJ
dti-1332	142	63	gene	gene	NOUN
dti-1332	142	64	targets	target	NOUN
dti-1332	142	65	.	.	PUNCT
dti-1332	143	1	table	table	NOUN
dti-1332	143	2	3	3	NUM
dti-1332	143	3	outlines	outline	VERB
dti-1332	143	4	the	the	DET
dti-1332	143	5	different	different	ADJ
dti-1332	143	6	rules	rule	NOUN
dti-1332	143	7	employed	employ	VERB
dti-1332	143	8	by	by	ADP
dti-1332	143	9	some	some	PRON
dti-1332	143	10	of	of	ADP
dti-1332	143	11	the	the	DET
dti-1332	143	12	leading	lead	VERB
dti-1332	143	13	companies	company	NOUN
dti-1332	143	14	in	in	ADP
dti-1332	143	15	sirna	sirna	PROPN
dti-1332	143	16	synthesis	synthesis	PROPN
dti-1332	143	17	.	.	PUNCT
dti-1332	144	1	most	most	ADJ
dti-1332	144	2	algorithms	algorithm	NOUN
dti-1332	144	3	designed	design	VERB
dti-1332	144	4	for	for	ADP
dti-1332	144	5	making	make	VERB
dti-1332	144	6	specifi	specifi	PROPN
dti-1332	144	7	c	c	PROPN
dti-1332	144	8	and	and	CCONJ
dti-1332	144	9	effi	effi	PROPN
dti-1332	144	10	cient	cient	PROPN
dti-1332	144	11	sirna	sirna	PROPN
dti-1332	144	12	with	with	ADP
dti-1332	144	13	minimized	minimized	PROPN
dti-1332	144	14	/	/	SYM
dti-1332	144	15	no	no	DET
dti-1332	144	16	off	off	ADP
dti-1332	144	17	-	-	PUNCT
dti-1332	144	18	target	target	NOUN
dti-1332	144	19	effects	effect	NOUN
dti-1332	144	20	involve	involve	VERB
dti-1332	144	21	a	a	DET
dti-1332	144	22	genome	genome	NOUN
dti-1332	144	23	wide	wide	ADJ
dti-1332	144	24	homology	homology	NOUN
dti-1332	144	25	search	search	NOUN
dti-1332	144	26	using	use	VERB
dti-1332	144	27	blast	blast	NOUN
dti-1332	144	28	(	(	PUNCT
dti-1332	144	29	behlke	behlke	ADJ
dti-1332	144	30	,	,	PUNCT
dti-1332	144	31	2006	2006	NUM
dti-1332	144	32	)	)	PUNCT
dti-1332	144	33	.	.	PUNCT
dti-1332	145	1	all	all	DET
dti-1332	145	2	the	the	DET
dti-1332	145	3	factors	factor	NOUN
dti-1332	145	4	related	relate	VERB
dti-1332	145	5	with	with	ADP
dti-1332	145	6	the	the	DET
dti-1332	145	7	off	off	ADP
dti-1332	145	8	-	-	PUNCT
dti-1332	145	9	target	target	NOUN
dti-1332	145	10	activity	activity	NOUN
dti-1332	145	11	have	have	VERB
dti-1332	145	12	to	to	PART
dti-1332	145	13	be	be	AUX
dti-1332	145	14	taken	take	VERB
dti-1332	145	15	into	into	ADP
dti-1332	145	16	consideration	consideration	NOUN
dti-1332	145	17	to	to	PART
dti-1332	145	18	design	design	VERB
dti-1332	145	19	a	a	DET
dti-1332	145	20	better	well	ADJ
dti-1332	145	21	algorithm	algorithm	NOUN
dti-1332	145	22	by	by	ADP
dti-1332	145	23	combining	combine	VERB
dti-1332	145	24	the	the	DET
dti-1332	145	25	rules	rule	NOUN
dti-1332	145	26	and	and	CCONJ
dti-1332	145	27	checking	check	VERB
dti-1332	145	28	all	all	DET
dti-1332	145	29	the	the	DET
dti-1332	145	30	responsible	responsible	ADJ
dti-1332	145	31	factors	factor	NOUN
dti-1332	145	32	because	because	SCONJ
dti-1332	145	33	even	even	ADV
dti-1332	145	34	a	a	DET
dti-1332	145	35	single	single	ADJ
dti-1332	145	36	mismatch	mismatch	NOUN
dti-1332	145	37	can	can	AUX
dti-1332	145	38	disrupt	disrupt	VERB
dti-1332	145	39	the	the	DET
dti-1332	145	40	sirna	sirna	PROPN
dti-1332	145	41	action	action	NOUN
dti-1332	145	42	against	against	ADP
dti-1332	145	43	an	an	DET
dti-1332	145	44	intended	intend	VERB
dti-1332	145	45	target	target	NOUN
dti-1332	145	46	(	(	PUNCT
dti-1332	145	47	amarguioui	amarguioui	ADJ
dti-1332	145	48	et	et	PROPN
dti-1332	145	49	al	al	PROPN
dti-1332	145	50	.	.	PROPN
dti-1332	145	51	2003	2003	NUM
dti-1332	145	52	)	)	PUNCT
dti-1332	145	53	.	.	PUNCT
dti-1332	146	1	an	an	DET
dti-1332	146	2	effective	effective	ADJ
dti-1332	146	3	algorithm	algorithm	NOUN
dti-1332	146	4	combines	combine	VERB
dti-1332	146	5	different	different	ADJ
dti-1332	146	6	rule	rule	NOUN
dti-1332	146	7	sets	set	NOUN
dti-1332	146	8	and	and	CCONJ
dti-1332	146	9	aligns	align	VERB
dti-1332	146	10	it	it	PRON
dti-1332	146	11	with	with	ADP
dti-1332	146	12	physico	physico	NOUN
dti-1332	146	13	-	-	PUNCT
dti-1332	146	14	chemical	chemical	NOUN
dti-1332	146	15	properties	property	NOUN
dti-1332	146	16	of	of	ADP
dti-1332	146	17	sirna	sirna	PROPN
dti-1332	146	18	and	and	CCONJ
dti-1332	146	19	its	its	PRON
dti-1332	146	20	functional	functional	ADJ
dti-1332	146	21	mechanism	mechanism	NOUN
dti-1332	146	22	inside	inside	ADP
dti-1332	146	23	the	the	DET
dti-1332	146	24	cell	cell	NOUN
dti-1332	146	25	.	.	PUNCT
dti-1332	147	1	this	this	PRON
dti-1332	147	2	is	be	AUX
dti-1332	147	3	done	do	VERB
dti-1332	147	4	in	in	ADP
dti-1332	147	5	order	order	NOUN
dti-1332	147	6	to	to	PART
dti-1332	147	7	avoid	avoid	VERB
dti-1332	147	8	the	the	DET
dti-1332	147	9	flaws	flaw	NOUN
dti-1332	147	10	in	in	ADP
dti-1332	147	11	the	the	DET
dti-1332	147	12	design	design	NOUN
dti-1332	147	13	and	and	CCONJ
dti-1332	147	14	enhance	enhance	VERB
dti-1332	147	15	its	its	PRON
dti-1332	147	16	effi	effi	PROPN
dti-1332	147	17	cacy	cacy	NOUN
dti-1332	147	18	and	and	CCONJ
dti-1332	147	19	hence	hence	ADV
dti-1332	147	20	reduce	reduce	VERB
dti-1332	147	21	the	the	DET
dti-1332	147	22	sirnas	sirnas	PROPN
dti-1332	147	23	cross	cross	NOUN
dti-1332	147	24	reactivity	reactivity	NOUN
dti-1332	147	25	and	and	CCONJ
dti-1332	147	26	non	non	ADJ
dti-1332	147	27	-	-	ADJ
dti-1332	147	28	specifi	specifi	ADJ
dti-1332	147	29	city	city	PROPN
dti-1332	147	30	as	as	ADV
dti-1332	147	31	well	well	ADV
dti-1332	147	32	as	as	ADP
dti-1332	147	33	fi	fi	NOUN
dti-1332	147	34	lter	lter	NOUN
dti-1332	147	35	out	out	ADP
dti-1332	147	36	off	off	ADP
dti-1332	147	37	-	-	PUNCT
dti-1332	147	38	targets	target	NOUN
dti-1332	147	39	and	and	CCONJ
dti-1332	147	40	produce	produce	VERB
dti-1332	147	41	sirnas	sirna	NOUN
dti-1332	147	42	which	which	PRON
dti-1332	147	43	are	be	AUX
dti-1332	147	44	highly	highly	ADV
dti-1332	147	45	effi	effi	PROPN
dti-1332	147	46	cient	cient	NOUN
dti-1332	147	47	in	in	ADP
dti-1332	147	48	degrading	degrade	VERB
dti-1332	147	49	the	the	DET
dti-1332	147	50	target	target	NOUN
dti-1332	147	51	mrna	mrna	PROPN
dti-1332	147	52	.	.	PUNCT
dti-1332	148	1	combining	combine	VERB
dti-1332	148	2	structural	structural	ADJ
dti-1332	148	3	and	and	CCONJ
dti-1332	148	4	computational	computational	ADJ
dti-1332	148	5	tools	tool	NOUN
dti-1332	148	6	open	open	VERB
dti-1332	148	7	new	new	ADJ
dti-1332	148	8	avenues	avenue	NOUN
dti-1332	148	9	for	for	ADP
dti-1332	148	10	adca	adca	ADJ
dti-1332	148	11	therapy	therapy	NOUN
dti-1332	148	12	both	both	CCONJ
dti-1332	148	13	at	at	ADP
dti-1332	148	14	the	the	DET
dti-1332	148	15	level	level	NOUN
dti-1332	148	16	of	of	ADP
dti-1332	148	17	new	new	ADJ
dti-1332	148	18	effective	effective	ADJ
dti-1332	148	19	targets	target	NOUN
dti-1332	148	20	for	for	ADP
dti-1332	148	21	sirna	sirna	PROPN
dti-1332	148	22	,	,	PUNCT
dti-1332	148	23	as	as	ADV
dti-1332	148	24	well	well	ADV
dti-1332	148	25	as	as	ADP
dti-1332	148	26	to	to	PART
dti-1332	148	27	avoid	avoid	VERB
dti-1332	148	28	any	any	DET
dti-1332	148	29	off	off	ADJ
dti-1332	148	30	-	-	PUNCT
dti-1332	148	31	target	target	NOUN
dti-1332	148	32	effects	effect	NOUN
dti-1332	148	33	.	.	PUNCT
dti-1332	149	1	computational	computational	ADJ
dti-1332	149	2	approaches	approach	NOUN
dti-1332	149	3	designing	design	VERB
dti-1332	149	4	effective	effective	ADJ
dti-1332	149	5	and	and	CCONJ
dti-1332	149	6	competitive	competitive	ADJ
dti-1332	149	7	algorithms	algorithm	NOUN
dti-1332	149	8	for	for	ADP
dti-1332	149	9	sirna	sirna	PROPN
dti-1332	149	10	synthesis	synthesis	NOUN
dti-1332	149	11	provide	provide	VERB
dti-1332	149	12	revolutionary	revolutionary	ADJ
dti-1332	149	13	capabilities	capability	NOUN
dti-1332	149	14	that	that	PRON
dti-1332	149	15	facilitate	facilitate	VERB
dti-1332	149	16	considerable	considerable	ADJ
dti-1332	149	17	improvements	improvement	NOUN
dti-1332	149	18	in	in	ADP
dti-1332	149	19	terms	term	NOUN
dti-1332	149	20	of	of	ADP
dti-1332	149	21	potency	potency	NOUN
dti-1332	149	22	and	and	CCONJ
dti-1332	149	23	specifi	specifi	PROPN
dti-1332	149	24	city	city	PROPN
dti-1332	149	25	table	table	NOUN
dti-1332	149	26	3	3	NUM
dti-1332	149	27	.	.	PUNCT
dti-1332	150	1	different	different	ADJ
dti-1332	150	2	rule	rule	NOUN
dti-1332	150	3	sets	set	NOUN
dti-1332	150	4	employed	employ	VERB
dti-1332	150	5	by	by	ADP
dti-1332	150	6	different	different	ADJ
dti-1332	150	7	companies	company	NOUN
dti-1332	150	8	to	to	PART
dti-1332	150	9	develop	develop	VERB
dti-1332	150	10	an	an	DET
dti-1332	150	11	effi	effi	PROPN
dti-1332	150	12	cient	cient	PROPN
dti-1332	150	13	sirna	sirna	PROPN
dti-1332	150	14	algorithm	algorithm	PROPN
dti-1332	150	15	.	.	PUNCT
dti-1332	151	1	company	company	NOUN
dti-1332	151	2	rules	rule	VERB
dti-1332	151	3	tuschl	tuschl	NOUN
dti-1332	151	4	tuschl	tuschl	PROPN
dti-1332	151	5	reynolds	reynold	NOUN
dti-1332	151	6	own	own	ADJ
dti-1332	151	7	rule	rule	NOUN
dti-1332	151	8	set	set	VERB
dti-1332	151	9	tuschl	tuschl	NOUN
dti-1332	151	10	reynolds	reynolds	PROPN
dti-1332	151	11	ui	ui	PROPN
dti-1332	151	12	-	-	PUNCT
dti-1332	151	13	tei	tei	NOUN
dti-1332	151	14	tuschl	tuschl	NOUN
dti-1332	151	15	tuschl	tuschl	NOUN
dti-1332	151	16	+	+	CCONJ
dti-1332	151	17	extra	extra	ADJ
dti-1332	151	18	rules	rule	NOUN
dti-1332	151	19	inference	inference	VERB
dti-1332	151	20	no	no	DET
dti-1332	151	21	rank	rank	NOUN
dti-1332	151	22	score	score	NOUN
dti-1332	151	23	,	,	PUNCT
dti-1332	151	24	link	link	VERB
dti-1332	151	25	to	to	PART
dti-1332	151	26	blast	blast	VERB
dti-1332	151	27	no	no	DET
dti-1332	151	28	rank	rank	NOUN
dti-1332	151	29	score	score	NOUN
dti-1332	151	30	,	,	PUNCT
dti-1332	151	31	link	link	VERB
dti-1332	151	32	to	to	PART
dti-1332	151	33	blast	blast	VERB
dti-1332	151	34	score	score	NOUN
dti-1332	151	35	/	/	SYM
dti-1332	151	36	rank	rank	NOUN
dti-1332	151	37	runs	run	NOUN
dti-1332	151	38	blast	blast	VERB
dti-1332	151	39	score	score	NOUN
dti-1332	151	40	/	/	SYM
dti-1332	151	41	rank	rank	NOUN
dti-1332	151	42	runs	run	NOUN
dti-1332	151	43	blast	blast	VERB
dti-1332	151	44	score	score	NOUN
dti-1332	151	45	/	/	SYM
dti-1332	151	46	rank	rank	NOUN
dti-1332	151	47	runs	run	NOUN
dti-1332	151	48	blast	blast	VERB
dti-1332	151	49	rank	rank	PROPN
dti-1332	151	50	/	/	SYM
dti-1332	152	1	no	no	DET
dti-1332	152	2	score	score	NOUN
dti-1332	152	3	runs	run	VERB
dti-1332	152	4	blast	blast	VERB
dti-1332	152	5	score	score	NOUN
dti-1332	152	6	/	/	SYM
dti-1332	152	7	rank	rank	NOUN
dti-1332	152	8	link	link	NOUN
dti-1332	152	9	to	to	PART
dti-1332	152	10	blast	blast	VERB
dti-1332	152	11	109	109	NUM
dti-1332	152	12	recent	recent	ADJ
dti-1332	152	13	advancements	advancement	NOUN
dti-1332	152	14	in	in	ADP
dti-1332	152	15	targeted	target	VERB
dti-1332	152	16	delivery	delivery	NOUN
dti-1332	152	17	of	of	ADP
dti-1332	152	18	therapeutic	therapeutic	ADJ
dti-1332	152	19	molecules	molecule	NOUN
dti-1332	152	20	drug	drug	NOUN
dti-1332	152	21	target	target	NOUN
dti-1332	152	22	insights	insight	NOUN
dti-1332	152	23	2008:3	2008:3	NUM
dti-1332	152	24	involving	involve	VERB
dti-1332	152	25	high	high	ADJ
dti-1332	152	26	through	through	ADP
dti-1332	152	27	-	-	PUNCT
dti-1332	152	28	put	put	NOUN
dti-1332	152	29	screening	screening	NOUN
dti-1332	152	30	,	,	PUNCT
dti-1332	152	31	effi	effi	PROPN
dti-1332	152	32	cient	cient	PROPN
dti-1332	152	33	validation	validation	NOUN
dti-1332	152	34	,	,	PUNCT
dti-1332	152	35	reliable	reliable	ADJ
dti-1332	152	36	scoring	scoring	NOUN
dti-1332	152	37	functions	function	NOUN
dti-1332	152	38	and	and	CCONJ
dti-1332	152	39	predictive	predictive	ADJ
dti-1332	152	40	mode	mode	NOUN
dti-1332	152	41	of	of	ADP
dti-1332	152	42	delivery	delivery	NOUN
dti-1332	152	43	.	.	PUNCT
dti-1332	153	1	challenges	challenge	NOUN
dti-1332	153	2	in	in	ADP
dti-1332	153	3	sirna	sirna	PROPN
dti-1332	153	4	delivery	delivery	NOUN
dti-1332	153	5	:	:	PUNCT
dti-1332	153	6	viral	viral	ADJ
dti-1332	153	7	vs	vs	ADP
dti-1332	153	8	non	non	ADJ
dti-1332	153	9	-	-	ADJ
dti-1332	153	10	viral	viral	ADJ
dti-1332	153	11	the	the	DET
dti-1332	153	12	organizational	organizational	ADJ
dti-1332	153	13	complexity	complexity	NOUN
dti-1332	153	14	of	of	ADP
dti-1332	153	15	nervous	nervous	ADJ
dti-1332	153	16	system	system	NOUN
dti-1332	153	17	offers	offer	VERB
dti-1332	153	18	many	many	ADJ
dti-1332	153	19	challenges	challenge	NOUN
dti-1332	153	20	to	to	PART
dti-1332	153	21	deliver	deliver	VERB
dti-1332	153	22	therapeutic	therapeutic	ADJ
dti-1332	153	23	molecules	molecule	NOUN
dti-1332	153	24	.	.	PUNCT
dti-1332	154	1	the	the	DET
dti-1332	154	2	blood	blood	NOUN
dti-1332	154	3	-	-	PUNCT
dti-1332	154	4	brain	brain	NOUN
dti-1332	154	5	-	-	PUNCT
dti-1332	154	6	barrier	barrier	NOUN
dti-1332	154	7	(	(	PUNCT
dti-1332	154	8	bbb	bbb	NOUN
dti-1332	154	9	)	)	PUNCT
dti-1332	154	10	and	and	CCONJ
dti-1332	154	11	cerebrospinal	cerebrospinal	ADJ
dti-1332	154	12	fl	fl	X
dti-1332	154	13	uid	uid	ADJ
dti-1332	154	14	(	(	PUNCT
dti-1332	154	15	csf	csf	NOUN
dti-1332	154	16	)	)	PUNCT
dti-1332	154	17	comprise	comprise	VERB
dti-1332	154	18	a	a	DET
dti-1332	154	19	systemic	systemic	ADJ
dti-1332	154	20	vascular	vascular	ADJ
dti-1332	154	21	systemic	systemic	NOUN
dti-1332	154	22	that	that	PRON
dti-1332	154	23	insulates	insulate	VERB
dti-1332	154	24	the	the	DET
dti-1332	154	25	parenchymal	parenchymal	ADJ
dti-1332	154	26	and	and	CCONJ
dti-1332	154	27	ventricular	ventricular	ADJ
dti-1332	154	28	compartment	compartment	NOUN
dti-1332	154	29	of	of	ADP
dti-1332	154	30	the	the	DET
dti-1332	154	31	cns	cns	NOUN
dti-1332	154	32	respectively	respectively	ADV
dti-1332	154	33	.	.	PUNCT
dti-1332	155	1	in	in	ADP
dti-1332	155	2	general	general	ADJ
dti-1332	155	3	bbb	bbb	PROPN
dti-1332	155	4	does	do	AUX
dti-1332	155	5	n’t	not	PART
dti-1332	155	6	allow	allow	VERB
dti-1332	155	7	the	the	DET
dti-1332	155	8	passage	passage	NOUN
dti-1332	155	9	of	of	ADP
dti-1332	155	10	any	any	DET
dti-1332	155	11	compound	compound	NOUN
dti-1332	155	12	that	that	PRON
dti-1332	155	13	is	be	AUX
dti-1332	155	14	hydrophilic	hydrophilic	ADJ
dti-1332	155	15	,	,	PUNCT
dti-1332	155	16	ionized	ionize	VERB
dti-1332	155	17	,	,	PUNCT
dti-1332	155	18	and	and	CCONJ
dti-1332	155	19	is	be	AUX
dti-1332	155	20	more	more	ADJ
dti-1332	155	21	than	than	ADP
dti-1332	155	22	500	500	NUM
dti-1332	155	23	da	da	NOUN
dti-1332	155	24	in	in	ADP
dti-1332	155	25	molecular	molecular	ADJ
dti-1332	155	26	weight	weight	NOUN
dti-1332	155	27	(	(	PUNCT
dti-1332	155	28	sanovich	sanovich	PROPN
dti-1332	155	29	et	et	PROPN
dti-1332	155	30	al	al	PROPN
dti-1332	155	31	.	.	PROPN
dti-1332	155	32	1995	1995	NUM
dti-1332	155	33	)	)	PUNCT
dti-1332	155	34	.	.	PUNCT
dti-1332	156	1	certain	certain	ADJ
dti-1332	156	2	strategies	strategy	NOUN
dti-1332	156	3	have	have	AUX
dti-1332	156	4	been	be	AUX
dti-1332	156	5	developed	develop	VERB
dti-1332	156	6	to	to	PART
dti-1332	156	7	transiently	transiently	ADV
dti-1332	156	8	increase	increase	VERB
dti-1332	156	9	the	the	DET
dti-1332	156	10	permeability	permeability	NOUN
dti-1332	156	11	of	of	ADP
dti-1332	156	12	the	the	DET
dti-1332	156	13	bbb	bbb	NOUN
dti-1332	156	14	by	by	ADP
dti-1332	156	15	using	use	VERB
dti-1332	156	16	a	a	DET
dti-1332	156	17	bradykynin	bradykynin	NOUN
dti-1332	156	18	analogue	analogue	NOUN
dti-1332	156	19	,	,	PUNCT
dti-1332	156	20	rmp-7	rmp-7	X
dti-1332	156	21	.	.	PUNCT
dti-1332	157	1	it	it	PRON
dti-1332	157	2	stimulates	stimulate	VERB
dti-1332	157	3	the	the	DET
dti-1332	157	4	b2	b2	NOUN
dti-1332	157	5	receptors	receptor	NOUN
dti-1332	157	6	present	present	ADJ
dti-1332	157	7	on	on	ADP
dti-1332	157	8	endothelial	endothelial	ADJ
dti-1332	157	9	cells	cell	NOUN
dti-1332	157	10	,	,	PUNCT
dti-1332	157	11	increases	increase	VERB
dti-1332	157	12	the	the	DET
dti-1332	157	13	intracellular	intracellular	ADJ
dti-1332	157	14	calcium	calcium	NOUN
dti-1332	157	15	infl	infl	PROPN
dti-1332	157	16	ux	ux	PROPN
dti-1332	157	17	and	and	CCONJ
dti-1332	157	18	facilitates	facilitate	VERB
dti-1332	157	19	transcellular	transcellular	ADJ
dti-1332	157	20	penetration	penetration	NOUN
dti-1332	157	21	by	by	ADP
dti-1332	157	22	means	mean	NOUN
dti-1332	157	23	of	of	ADP
dti-1332	157	24	receptor	receptor	NOUN
dti-1332	157	25	-	-	PUNCT
dti-1332	157	26	mediated	mediate	VERB
dti-1332	157	27	transcytosis	transcytosis	NOUN
dti-1332	157	28	of	of	ADP
dti-1332	157	29	therapeutic	therapeutic	ADJ
dti-1332	157	30	molecules	molecule	NOUN
dti-1332	157	31	(	(	PUNCT
dti-1332	157	32	riley	riley	PROPN
dti-1332	157	33	et	et	PROPN
dti-1332	157	34	al	al	PROPN
dti-1332	157	35	.	.	PROPN
dti-1332	157	36	1998	1998	NUM
dti-1332	157	37	)	)	PUNCT
dti-1332	157	38	.	.	PUNCT
dti-1332	158	1	it	it	PRON
dti-1332	158	2	is	be	AUX
dti-1332	158	3	further	far	ADV
dti-1332	158	4	believed	believe	VERB
dti-1332	158	5	that	that	SCONJ
dti-1332	158	6	discovery	discovery	PROPN
dti-1332	158	7	and	and	CCONJ
dti-1332	158	8	identifi	identifi	NOUN
dti-1332	158	9	cation	cation	NOUN
dti-1332	158	10	of	of	ADP
dti-1332	158	11	novel	novel	ADJ
dti-1332	158	12	transporters	transporter	NOUN
dti-1332	158	13	expressed	express	VERB
dti-1332	158	14	on	on	ADP
dti-1332	158	15	the	the	DET
dti-1332	158	16	surface	surface	NOUN
dti-1332	158	17	of	of	ADP
dti-1332	158	18	brain	brain	NOUN
dti-1332	158	19	capillary	capillary	ADJ
dti-1332	158	20	endothelium	endothelium	NOUN
dti-1332	158	21	would	would	AUX
dti-1332	158	22	facilitate	facilitate	VERB
dti-1332	158	23	rapid	rapid	ADJ
dti-1332	158	24	uptake	uptake	NOUN
dti-1332	158	25	of	of	ADP
dti-1332	158	26	therapeutic	therapeutic	ADJ
dti-1332	158	27	molecules	molecule	NOUN
dti-1332	158	28	thus	thus	ADV
dti-1332	158	29	,	,	PUNCT
dti-1332	158	30	solving	solve	VERB
dti-1332	158	31	the	the	DET
dti-1332	158	32	problem	problem	NOUN
dti-1332	158	33	of	of	ADP
dti-1332	158	34	bbb	bbb	PROPN
dti-1332	158	35	(	(	PUNCT
dti-1332	158	36	forte	forte	PROPN
dti-1332	158	37	et	et	PROPN
dti-1332	158	38	al	al	PROPN
dti-1332	158	39	.	.	PROPN
dti-1332	158	40	2005	2005	NUM
dti-1332	158	41	)	)	PUNCT
dti-1332	158	42	.	.	PUNCT
dti-1332	159	1	crossing	cross	VERB
dti-1332	159	2	and	and	CCONJ
dti-1332	159	3	traversing	traverse	VERB
dti-1332	159	4	through	through	ADP
dti-1332	159	5	these	these	DET
dti-1332	159	6	insulations	insulation	NOUN
dti-1332	159	7	/	/	SYM
dti-1332	159	8	barriers	barrier	NOUN
dti-1332	159	9	and	and	CCONJ
dti-1332	159	10	reaching	reach	VERB
dti-1332	159	11	the	the	DET
dti-1332	159	12	targeted	target	VERB
dti-1332	159	13	site	site	NOUN
dti-1332	159	14	that	that	PRON
dti-1332	159	15	too	too	ADV
dti-1332	159	16	cell	cell	NOUN
dti-1332	159	17	specifi	specifi	PROPN
dti-1332	159	18	c	c	PROPN
dti-1332	159	19	does	do	AUX
dti-1332	159	20	not	not	PART
dti-1332	159	21	only	only	ADV
dti-1332	159	22	depend	depend	VERB
dti-1332	159	23	on	on	ADP
dti-1332	159	24	the	the	DET
dti-1332	159	25	delivery	delivery	NOUN
dti-1332	159	26	mechanisms	mechanism	NOUN
dti-1332	159	27	of	of	ADP
dti-1332	159	28	sirna	sirna	PROPN
dti-1332	159	29	or	or	CCONJ
dti-1332	159	30	its	its	PRON
dti-1332	159	31	carrier	carrier	NOUN
dti-1332	159	32	but	but	CCONJ
dti-1332	159	33	also	also	ADV
dti-1332	159	34	on	on	ADP
dti-1332	159	35	the	the	DET
dti-1332	159	36	route	route	NOUN
dti-1332	159	37	of	of	ADP
dti-1332	159	38	administration	administration	NOUN
dti-1332	159	39	(	(	PUNCT
dti-1332	159	40	wood	wood	NOUN
dti-1332	159	41	et	et	PROPN
dti-1332	159	42	al	al	PROPN
dti-1332	159	43	.	.	PROPN
dti-1332	159	44	2003	2003	NUM
dti-1332	159	45	)	)	PUNCT
dti-1332	159	46	.	.	PUNCT
dti-1332	160	1	the	the	DET
dti-1332	160	2	route	route	NOUN
dti-1332	160	3	of	of	ADP
dti-1332	160	4	administration	administration	NOUN
dti-1332	160	5	determines	determine	VERB
dti-1332	160	6	the	the	DET
dti-1332	160	7	amount	amount	NOUN
dti-1332	160	8	of	of	ADP
dti-1332	160	9	dose	dose	NOUN
dti-1332	160	10	required	require	VERB
dti-1332	160	11	to	to	PART
dti-1332	160	12	obtain	obtain	VERB
dti-1332	160	13	an	an	DET
dti-1332	160	14	optimal	optimal	ADJ
dti-1332	160	15	effect	effect	NOUN
dti-1332	160	16	,	,	PUNCT
dti-1332	160	17	proper	proper	ADJ
dti-1332	160	18	tissue	tissue	NOUN
dti-1332	160	19	distribution	distribution	NOUN
dti-1332	160	20	and	and	CCONJ
dti-1332	160	21	minimal	minimal	ADJ
dti-1332	160	22	sideeffects	sideeffect	NOUN
dti-1332	160	23	.	.	PUNCT
dti-1332	161	1	for	for	ADP
dti-1332	161	2	broad	broad	ADJ
dti-1332	161	3	tissue	tissue	NOUN
dti-1332	161	4	distribution	distribution	NOUN
dti-1332	161	5	intravenous	intravenous	ADJ
dti-1332	161	6	administration	administration	NOUN
dti-1332	161	7	is	be	AUX
dti-1332	161	8	often	often	ADV
dti-1332	161	9	preferred	prefer	VERB
dti-1332	161	10	while	while	SCONJ
dti-1332	161	11	others	other	NOUN
dti-1332	161	12	like	like	ADP
dti-1332	161	13	intraperitoneal	intraperitoneal	NOUN
dti-1332	161	14	(	(	PUNCT
dti-1332	161	15	ip	ip	NOUN
dti-1332	161	16	)	)	PUNCT
dti-1332	161	17	and	and	CCONJ
dti-1332	161	18	subcutaneous	subcutaneous	ADJ
dti-1332	161	19	(	(	PUNCT
dti-1332	161	20	sc	sc	NOUN
dti-1332	161	21	)	)	PUNCT
dti-1332	161	22	can	can	AUX
dti-1332	161	23	also	also	ADV
dti-1332	161	24	be	be	AUX
dti-1332	161	25	utilized	utilize	VERB
dti-1332	161	26	.	.	PUNCT
dti-1332	162	1	local	local	ADJ
dti-1332	162	2	delivery	delivery	NOUN
dti-1332	162	3	can	can	AUX
dti-1332	162	4	be	be	AUX
dti-1332	162	5	achieved	achieve	VERB
dti-1332	162	6	by	by	ADP
dti-1332	162	7	direct	direct	ADJ
dti-1332	162	8	injection	injection	NOUN
dti-1332	162	9	into	into	ADP
dti-1332	162	10	joint	joint	ADJ
dti-1332	162	11	or	or	CCONJ
dti-1332	162	12	tumor	tumor	NOUN
dti-1332	162	13	or	or	CCONJ
dti-1332	162	14	by	by	ADP
dti-1332	162	15	topical	topical	ADJ
dti-1332	162	16	application	application	NOUN
dti-1332	162	17	to	to	ADP
dti-1332	162	18	the	the	DET
dti-1332	162	19	surface	surface	NOUN
dti-1332	162	20	i.e.	i.e.	X
dti-1332	162	21	transepithelial	transepithelial	ADJ
dti-1332	162	22	application	application	NOUN
dti-1332	162	23	via	via	ADP
dti-1332	162	24	oral	oral	ADJ
dti-1332	162	25	,	,	PUNCT
dti-1332	162	26	rectal	rectal	ADJ
dti-1332	162	27	or	or	CCONJ
dti-1332	162	28	vaginal	vaginal	ADJ
dti-1332	162	29	mucosa	mucosa	NOUN
dti-1332	162	30	.	.	PUNCT
dti-1332	163	1	direct	direct	ADJ
dti-1332	163	2	administration	administration	NOUN
dti-1332	163	3	to	to	ADP
dti-1332	163	4	central	central	ADJ
dti-1332	163	5	nervous	nervous	ADJ
dti-1332	163	6	system	system	NOUN
dti-1332	163	7	(	(	PUNCT
dti-1332	163	8	cns	cns	NOUN
dti-1332	163	9	)	)	PUNCT
dti-1332	163	10	can	can	AUX
dti-1332	163	11	also	also	ADV
dti-1332	163	12	be	be	AUX
dti-1332	163	13	achieved	achieve	VERB
dti-1332	163	14	by	by	ADP
dti-1332	163	15	intrathecal	intrathecal	ADJ
dti-1332	163	16	or	or	CCONJ
dti-1332	163	17	intraventricular	intraventricular	ADJ
dti-1332	163	18	injection	injection	NOUN
dti-1332	163	19	(	(	PUNCT
dti-1332	163	20	behlke	behlke	ADJ
dti-1332	163	21	,	,	PUNCT
dti-1332	163	22	2006	2006	NUM
dti-1332	163	23	)	)	PUNCT
dti-1332	163	24	.	.	PUNCT
dti-1332	164	1	local	local	ADJ
dti-1332	164	2	delivery	delivery	NOUN
dti-1332	164	3	achieves	achieve	VERB
dti-1332	164	4	less	less	ADJ
dti-1332	164	5	risk	risk	NOUN
dti-1332	164	6	against	against	ADP
dti-1332	164	7	systemic	systemic	ADJ
dti-1332	164	8	side	side	NOUN
dti-1332	164	9	effects	effect	NOUN
dti-1332	164	10	with	with	ADP
dti-1332	164	11	less	less	ADJ
dti-1332	164	12	amount	amount	NOUN
dti-1332	164	13	and	and	CCONJ
dti-1332	164	14	high	high	ADJ
dti-1332	164	15	concentration	concentration	NOUN
dti-1332	164	16	of	of	ADP
dti-1332	164	17	the	the	DET
dti-1332	164	18	drug	drug	NOUN
dti-1332	164	19	at	at	ADP
dti-1332	164	20	the	the	DET
dti-1332	164	21	anticipated	anticipate	VERB
dti-1332	164	22	target	target	NOUN
dti-1332	164	23	site	site	NOUN
dti-1332	164	24	.	.	PUNCT
dti-1332	165	1	though	though	ADV
dti-1332	165	2	,	,	PUNCT
dti-1332	165	3	chemically	chemically	ADV
dti-1332	165	4	modifi	modifi	PROPN
dti-1332	165	5	ed	ed	PROPN
dti-1332	165	6	duplexes	duplex	NOUN
dti-1332	165	7	are	be	AUX
dti-1332	165	8	stable	stable	ADJ
dti-1332	165	9	,	,	PUNCT
dti-1332	165	10	they	they	PRON
dti-1332	165	11	can	can	AUX
dti-1332	165	12	be	be	AUX
dti-1332	165	13	rapidly	rapidly	ADV
dti-1332	165	14	cleared	clear	VERB
dti-1332	165	15	by	by	ADP
dti-1332	165	16	the	the	DET
dti-1332	165	17	plasma	plasma	NOUN
dti-1332	165	18	,	,	PUNCT
dti-1332	165	19	therefore	therefore	ADV
dti-1332	165	20	delivery	delivery	NOUN
dti-1332	165	21	vehicles	vehicle	NOUN
dti-1332	165	22	are	be	AUX
dti-1332	165	23	used	use	VERB
dti-1332	165	24	to	to	PART
dti-1332	165	25	improve	improve	VERB
dti-1332	165	26	the	the	DET
dti-1332	165	27	durability	durability	NOUN
dti-1332	165	28	and	and	CCONJ
dti-1332	165	29	pharmacokinetics	pharmacokinetic	NOUN
dti-1332	165	30	.	.	PUNCT
dti-1332	166	1	viral	viral	ADJ
dti-1332	166	2	mediated	mediate	VERB
dti-1332	166	3	sirna	sirna	PROPN
dti-1332	166	4	delivery	delivery	PROPN
dti-1332	166	5	viral	viral	ADJ
dti-1332	166	6	delivery	delivery	NOUN
dti-1332	166	7	of	of	ADP
dti-1332	166	8	therapeutic	therapeutic	ADJ
dti-1332	166	9	molecules	molecule	NOUN
dti-1332	166	10	has	have	AUX
dti-1332	166	11	been	be	AUX
dti-1332	166	12	demonstrated	demonstrate	VERB
dti-1332	166	13	in	in	ADP
dti-1332	166	14	few	few	ADJ
dti-1332	166	15	publications	publication	NOUN
dti-1332	166	16	for	for	ADP
dti-1332	166	17	neurodegenerative	neurodegenerative	ADJ
dti-1332	166	18	diseases	disease	NOUN
dti-1332	166	19	.	.	PUNCT
dti-1332	167	1	recombinant	recombinant	ADJ
dti-1332	167	2	adeno	adeno	NOUN
dti-1332	167	3	-	-	PUNCT
dti-1332	167	4	associated	associate	VERB
dti-1332	167	5	(	(	PUNCT
dti-1332	167	6	raav	raav	NOUN
dti-1332	167	7	)	)	PUNCT
dti-1332	167	8	virus	virus	NOUN
dti-1332	167	9	and	and	CCONJ
dti-1332	167	10	lentiviruses	lentiviruse	NOUN
dti-1332	167	11	has	have	AUX
dti-1332	167	12	gained	gain	VERB
dti-1332	167	13	a	a	DET
dti-1332	167	14	lot	lot	NOUN
dti-1332	167	15	of	of	ADP
dti-1332	167	16	importance	importance	NOUN
dti-1332	167	17	to	to	PART
dti-1332	167	18	deliver	deliver	VERB
dti-1332	167	19	shrna	shrna	NOUN
dti-1332	167	20	to	to	ADP
dti-1332	167	21	cns	cns	PROPN
dti-1332	167	22	.	.	PUNCT
dti-1332	168	1	aav	aav	PROPN
dti-1332	168	2	possess	possess	VERB
dti-1332	168	3	a	a	DET
dti-1332	168	4	small	small	ADJ
dti-1332	168	5	capsid	capsid	NOUN
dti-1332	168	6	of	of	ADP
dti-1332	168	7	20	20	NUM
dti-1332	168	8	nm	nm	NOUN
dti-1332	168	9	in	in	ADP
dti-1332	168	10	diameter	diameter	NOUN
dti-1332	168	11	encasing	encase	VERB
dti-1332	168	12	a	a	DET
dti-1332	168	13	small	small	ADJ
dti-1332	168	14	genome	genome	NOUN
dti-1332	168	15	of	of	ADP
dti-1332	168	16	4.6	4.6	NUM
dti-1332	168	17	kilobases	kilobase	NOUN
dti-1332	168	18	(	(	PUNCT
dti-1332	168	19	rodriguez	rodriguez	NOUN
dti-1332	168	20	-	-	PUNCT
dti-1332	168	21	lebron	lebron	PROPN
dti-1332	168	22	et	et	PROPN
dti-1332	168	23	al	al	PROPN
dti-1332	168	24	.	.	PROPN
dti-1332	168	25	2006	2006	NUM
dti-1332	168	26	)	)	PUNCT
dti-1332	168	27	.	.	PUNCT
dti-1332	169	1	ten	ten	NUM
dti-1332	169	2	known	know	VERB
dti-1332	169	3	aav	aav	NOUN
dti-1332	169	4	serotypes	serotype	NOUN
dti-1332	169	5	have	have	AUX
dti-1332	169	6	already	already	ADV
dti-1332	169	7	been	be	AUX
dti-1332	169	8	cloned	clone	VERB
dti-1332	169	9	and	and	CCONJ
dti-1332	169	10	are	be	AUX
dti-1332	169	11	now	now	ADV
dti-1332	169	12	being	be	AUX
dti-1332	169	13	used	use	VERB
dti-1332	169	14	as	as	ADP
dti-1332	169	15	recombinant	recombinant	ADJ
dti-1332	169	16	vectors	vector	NOUN
dti-1332	169	17	,	,	PUNCT
dti-1332	169	18	out	out	ADP
dti-1332	169	19	of	of	ADP
dti-1332	169	20	which	which	PRON
dti-1332	169	21	serotype	serotype	ADJ
dti-1332	169	22	1	1	NUM
dti-1332	169	23	and	and	CCONJ
dti-1332	169	24	5	5	NUM
dti-1332	169	25	have	have	AUX
dti-1332	169	26	been	be	AUX
dti-1332	169	27	reported	report	VERB
dti-1332	169	28	to	to	PART
dti-1332	169	29	successfully	successfully	ADV
dti-1332	169	30	transduce	transduce	VERB
dti-1332	169	31	any	any	DET
dti-1332	169	32	part	part	NOUN
dti-1332	169	33	of	of	ADP
dti-1332	169	34	cns	cns	PROPN
dti-1332	169	35	(	(	PUNCT
dti-1332	169	36	burger	burger	X
dti-1332	169	37	et	et	PROPN
dti-1332	169	38	al	al	PROPN
dti-1332	169	39	.	.	PROPN
dti-1332	169	40	2004	2004	NUM
dti-1332	169	41	)	)	PUNCT
dti-1332	169	42	.	.	PUNCT
dti-1332	170	1	moreover	moreover	ADV
dti-1332	170	2	,	,	PUNCT
dti-1332	170	3	production	production	NOUN
dti-1332	170	4	protocols	protocol	NOUN
dti-1332	170	5	have	have	AUX
dti-1332	170	6	already	already	ADV
dti-1332	170	7	been	be	AUX
dti-1332	170	8	optimized	optimize	VERB
dti-1332	170	9	for	for	ADP
dti-1332	170	10	large	large	ADJ
dti-1332	170	11	scale	scale	NOUN
dti-1332	170	12	production	production	NOUN
dti-1332	170	13	of	of	ADP
dti-1332	170	14	clinical	clinical	ADJ
dti-1332	170	15	grade	grade	NOUN
dti-1332	170	16	raav	raav	NOUN
dti-1332	170	17	(	(	PUNCT
dti-1332	170	18	grimm	grimm	NOUN
dti-1332	170	19	and	and	CCONJ
dti-1332	170	20	kleinschmidt	kleinschmidt	ADJ
dti-1332	170	21	,	,	PUNCT
dti-1332	170	22	1999	1999	NUM
dti-1332	170	23	)	)	PUNCT
dti-1332	170	24	.	.	PUNCT
dti-1332	171	1	they	they	PRON
dti-1332	171	2	have	have	AUX
dti-1332	171	3	been	be	AUX
dti-1332	171	4	used	use	VERB
dti-1332	171	5	to	to	PART
dti-1332	171	6	deliver	deliver	VERB
dti-1332	171	7	shrnas	shrna	NOUN
dti-1332	171	8	against	against	ADP
dti-1332	171	9	ataxin	ataxin	NOUN
dti-1332	171	10	-1	-1	PUNCT
dti-1332	171	11	in	in	ADP
dti-1332	171	12	sca1	sca1	NOUN
dti-1332	171	13	transgenic	transgenic	NOUN
dti-1332	171	14	mice	mouse	NOUN
dti-1332	171	15	and	and	CCONJ
dti-1332	171	16	mediate	mediate	VERB
dti-1332	171	17	an	an	DET
dti-1332	171	18	effi	effi	PROPN
dti-1332	171	19	cient	cient	NOUN
dti-1332	171	20	transduction	transduction	NOUN
dti-1332	171	21	(	(	PUNCT
dti-1332	171	22	xia	xia	PROPN
dti-1332	171	23	et	et	PROPN
dti-1332	171	24	al	al	PROPN
dti-1332	171	25	.	.	PROPN
dti-1332	171	26	2004	2004	NUM
dti-1332	171	27	)	)	PUNCT
dti-1332	171	28	.	.	PUNCT
dti-1332	172	1	the	the	DET
dti-1332	172	2	same	same	ADJ
dti-1332	172	3	has	have	AUX
dti-1332	172	4	also	also	ADV
dti-1332	172	5	been	be	AUX
dti-1332	172	6	achieved	achieve	VERB
dti-1332	172	7	against	against	ADP
dti-1332	172	8	huntington	huntington	PROPN
dti-1332	172	9	disease	disease	NOUN
dti-1332	172	10	(	(	PUNCT
dti-1332	172	11	harper	harper	NOUN
dti-1332	172	12	et	et	PROPN
dti-1332	172	13	al	al	PROPN
dti-1332	172	14	.	.	PROPN
dti-1332	172	15	2005	2005	NUM
dti-1332	172	16	)	)	PUNCT
dti-1332	172	17	.	.	PUNCT
dti-1332	173	1	like	like	ADP
dti-1332	173	2	spinocerebellar	spinocerebellar	ADJ
dti-1332	173	3	ataxia	ataxia	NOUN
dti-1332	173	4	,	,	PUNCT
dti-1332	173	5	huntington	huntington	PROPN
dti-1332	173	6	disease	disease	NOUN
dti-1332	173	7	is	be	AUX
dti-1332	173	8	also	also	ADV
dti-1332	173	9	caused	cause	VERB
dti-1332	173	10	by	by	ADP
dti-1332	173	11	cag	cag	PROPN
dti-1332	173	12	expansion	expansion	NOUN
dti-1332	173	13	leading	lead	VERB
dti-1332	173	14	to	to	ADP
dti-1332	173	15	neurodegeneration	neurodegeneration	NOUN
dti-1332	173	16	but	but	CCONJ
dti-1332	173	17	in	in	ADP
dti-1332	173	18	the	the	DET
dti-1332	173	19	striatum	striatum	NOUN
dti-1332	173	20	and	and	CCONJ
dti-1332	173	21	cortex	cortex	NOUN
dti-1332	173	22	reduction	reduction	NOUN
dti-1332	173	23	in	in	ADP
dti-1332	173	24	the	the	DET
dti-1332	173	25	production	production	NOUN
dti-1332	173	26	of	of	ADP
dti-1332	173	27	protein	protein	NOUN
dti-1332	173	28	after	after	SCONJ
dti-1332	173	29	treatment	treatment	NOUN
dti-1332	173	30	can	can	AUX
dti-1332	173	31	be	be	AUX
dti-1332	173	32	quantifi	quantifi	ADJ
dti-1332	173	33	ed	ed	NOUN
dti-1332	173	34	by	by	ADP
dti-1332	173	35	western	western	ADJ
dti-1332	173	36	blot	blot	NOUN
dti-1332	173	37	analysis	analysis	NOUN
dti-1332	173	38	and	and	CCONJ
dti-1332	173	39	the	the	DET
dti-1332	173	40	corresponding	corresponding	ADJ
dti-1332	173	41	reduction	reduction	NOUN
dti-1332	173	42	in	in	ADP
dti-1332	173	43	mrna	mrna	PROPN
dti-1332	173	44	levels	level	NOUN
dti-1332	173	45	can	can	AUX
dti-1332	173	46	be	be	AUX
dti-1332	173	47	assessed	assess	VERB
dti-1332	173	48	by	by	ADP
dti-1332	173	49	quantitative	quantitative	ADJ
dti-1332	173	50	pcr	pcr	NOUN
dti-1332	173	51	.	.	PUNCT
dti-1332	174	1	likewise	likewise	ADV
dti-1332	174	2	,	,	PUNCT
dti-1332	174	3	lentiviral	lentiviral	ADJ
dti-1332	174	4	(	(	PUNCT
dti-1332	174	5	lv	lv	PROPN
dti-1332	174	6	)	)	PUNCT
dti-1332	174	7	vectors	vector	NOUN
dti-1332	174	8	have	have	AUX
dti-1332	174	9	also	also	ADV
dti-1332	174	10	been	be	AUX
dti-1332	174	11	used	use	VERB
dti-1332	174	12	to	to	PART
dti-1332	174	13	deliver	deliver	VERB
dti-1332	174	14	shrnas	shrna	NOUN
dti-1332	174	15	resulting	result	VERB
dti-1332	174	16	in	in	ADP
dti-1332	174	17	effective	effective	ADJ
dti-1332	174	18	silencing	silencing	NOUN
dti-1332	174	19	of	of	ADP
dti-1332	174	20	the	the	DET
dti-1332	174	21	diseased	diseased	ADJ
dti-1332	174	22	gene	gene	NOUN
dti-1332	174	23	like	like	ADP
dti-1332	174	24	in	in	ADP
dti-1332	174	25	case	case	NOUN
dti-1332	174	26	of	of	ADP
dti-1332	174	27	superoxide	superoxide	NOUN
dti-1332	174	28	dismutase	dismutase	NOUN
dti-1332	174	29	(	(	PUNCT
dti-1332	174	30	sod1	sod1	NOUN
dti-1332	174	31	)	)	PUNCT
dti-1332	174	32	transgenic	transgenic	NOUN
dti-1332	174	33	mouse	mouse	NOUN
dti-1332	174	34	model	model	NOUN
dti-1332	174	35	of	of	ADP
dti-1332	174	36	als	als	NOUN
dti-1332	174	37	(	(	PUNCT
dti-1332	174	38	ralph	ralph	PROPN
dti-1332	174	39	et	et	PROPN
dti-1332	174	40	al	al	PROPN
dti-1332	174	41	.	.	PROPN
dti-1332	174	42	2005	2005	NUM
dti-1332	174	43	;	;	PUNCT
dti-1332	174	44	raoul	raoul	PROPN
dti-1332	174	45	et	et	PROPN
dti-1332	174	46	al	al	PROPN
dti-1332	174	47	.	.	PROPN
dti-1332	174	48	2005	2005	NUM
dti-1332	174	49	)	)	PUNCT
dti-1332	174	50	and	and	CCONJ
dti-1332	174	51	in	in	ADP
dti-1332	174	52	alzheimer	alzheimer	PROPN
dti-1332	174	53	’s	’s	PART
dti-1332	174	54	disease	disease	NOUN
dti-1332	174	55	by	by	ADP
dti-1332	174	56	using	use	VERB
dti-1332	174	57	bace1	bace1	PROPN
dti-1332	174	58	shrna	shrna	NOUN
dti-1332	174	59	in	in	ADP
dti-1332	174	60	lv	lv	PROPN
dti-1332	174	61	vectors	vector	NOUN
dti-1332	174	62	.	.	PUNCT
dti-1332	175	1	bace1	bace1	PROPN
dti-1332	175	2	is	be	AUX
dti-1332	175	3	responsible	responsible	ADJ
dti-1332	175	4	for	for	ADP
dti-1332	175	5	initial	initial	ADJ
dti-1332	175	6	cleavage	cleavage	NOUN
dti-1332	175	7	of	of	ADP
dti-1332	175	8	app	app	NOUN
dti-1332	175	9	that	that	PRON
dti-1332	175	10	is	be	AUX
dti-1332	175	11	believed	believe	VERB
dti-1332	175	12	to	to	PART
dti-1332	175	13	play	play	VERB
dti-1332	175	14	a	a	DET
dti-1332	175	15	major	major	ADJ
dti-1332	175	16	role	role	NOUN
dti-1332	175	17	in	in	ADP
dti-1332	175	18	the	the	DET
dti-1332	175	19	pathogenesis	pathogenesis	NOUN
dti-1332	175	20	of	of	ADP
dti-1332	175	21	alzheimer	alzheimer	PROPN
dti-1332	175	22	disease	disease	PROPN
dti-1332	175	23	.	.	PUNCT
dti-1332	176	1	therefore	therefore	ADV
dti-1332	176	2	,	,	PUNCT
dti-1332	176	3	inhibition	inhibition	NOUN
dti-1332	176	4	of	of	ADP
dti-1332	176	5	enzyme	enzyme	NOUN
dti-1332	176	6	bace1	bace1	NOUN
dti-1332	176	7	using	use	VERB
dti-1332	176	8	shrnas	shrnas	PROPN
dti-1332	176	9	has	have	AUX
dti-1332	176	10	given	give	VERB
dti-1332	176	11	a	a	DET
dti-1332	176	12	new	new	ADJ
dti-1332	176	13	perspective	perspective	NOUN
dti-1332	176	14	to	to	PART
dti-1332	176	15	treat	treat	VERB
dti-1332	176	16	alzheimer	alzheimer	NOUN
dti-1332	176	17	disease	disease	NOUN
dti-1332	176	18	(	(	PUNCT
dti-1332	176	19	singer	singer	NOUN
dti-1332	176	20	et	et	NOUN
dti-1332	176	21	al	al	PROPN
dti-1332	176	22	.	.	PROPN
dti-1332	176	23	2005	2005	NUM
dti-1332	176	24	)	)	PUNCT
dti-1332	176	25	.	.	PUNCT
dti-1332	177	1	also	also	ADV
dti-1332	177	2	,	,	PUNCT
dti-1332	177	3	different	different	ADJ
dti-1332	177	4	studies	study	NOUN
dti-1332	177	5	have	have	AUX
dti-1332	177	6	adopted	adopt	VERB
dti-1332	177	7	use	use	NOUN
dti-1332	177	8	of	of	ADP
dti-1332	177	9	modifi	modifi	PROPN
dti-1332	177	10	ed	ed	PROPN
dti-1332	177	11	virus	virus	NOUN
dti-1332	177	12	envelopes	envelope	NOUN
dti-1332	177	13	as	as	ADP
dti-1332	177	14	carriers	carrier	NOUN
dti-1332	177	15	like	like	ADP
dti-1332	177	16	fusogenic	fusogenic	PROPN
dti-1332	177	17	infl	infl	PROPN
dti-1332	177	18	uenza	uenza	PROPN
dti-1332	177	19	virus	virus	PROPN
dti-1332	177	20	(	(	PUNCT
dti-1332	177	21	de	de	PROPN
dti-1332	177	22	jonge	jonge	PROPN
dti-1332	177	23	et	et	PROPN
dti-1332	177	24	al	al	PROPN
dti-1332	177	25	.	.	PROPN
dti-1332	177	26	2006	2006	NUM
dti-1332	177	27	)	)	PUNCT
dti-1332	177	28	,	,	PUNCT
dti-1332	177	29	hemagglutinating	hemagglutinate	VERB
dti-1332	177	30	virus	virus	NOUN
dti-1332	177	31	of	of	ADP
dti-1332	177	32	japan	japan	PROPN
dti-1332	177	33	(	(	PUNCT
dti-1332	177	34	ito	ito	PROPN
dti-1332	177	35	et	et	PROPN
dti-1332	177	36	al	al	PROPN
dti-1332	177	37	.	.	PROPN
dti-1332	177	38	2005	2005	NUM
dti-1332	177	39	)	)	PUNCT
dti-1332	177	40	and	and	CCONJ
dti-1332	177	41	sv40	sv40	PROPN
dti-1332	177	42	pseudovirions	pseudovirion	NOUN
dti-1332	177	43	(	(	PUNCT
dti-1332	177	44	kimchi	kimchi	NOUN
dti-1332	177	45	-	-	PUNCT
dti-1332	177	46	sarfaty	sarfaty	NOUN
dti-1332	177	47	et	et	PROPN
dti-1332	177	48	al	al	PROPN
dti-1332	177	49	.	.	PROPN
dti-1332	177	50	2005	2005	NUM
dti-1332	177	51	)	)	PUNCT
dti-1332	177	52	to	to	PART
dti-1332	177	53	deliver	deliver	VERB
dti-1332	177	54	sirnas	sirna	NOUN
dti-1332	177	55	in	in	ADP
dti-1332	177	56	vivo	vivo	NOUN
dti-1332	177	57	.	.	PUNCT
dti-1332	178	1	recombinant	recombinant	ADJ
dti-1332	178	2	viruses	virus	NOUN
dti-1332	178	3	are	be	AUX
dti-1332	178	4	able	able	ADJ
dti-1332	178	5	to	to	PART
dti-1332	178	6	transfect	transfect	VERB
dti-1332	178	7	neurons	neuron	NOUN
dti-1332	178	8	because	because	SCONJ
dti-1332	178	9	their	their	PRON
dti-1332	178	10	envelope	envelope	NOUN
dti-1332	178	11	is	be	AUX
dti-1332	178	12	replaced	replace	VERB
dti-1332	178	13	by	by	ADP
dti-1332	178	14	another	another	DET
dti-1332	178	15	virus	virus	NOUN
dti-1332	178	16	to	to	PART
dti-1332	178	17	achieve	achieve	VERB
dti-1332	178	18	the	the	DET
dti-1332	178	19	tropism	tropism	NOUN
dti-1332	178	20	of	of	ADP
dti-1332	178	21	the	the	DET
dti-1332	178	22	desired	desire	VERB
dti-1332	178	23	cell	cell	NOUN
dti-1332	178	24	110	110	NUM
dti-1332	178	25	prakash	prakash	PROPN
dti-1332	178	26	and	and	CCONJ
dti-1332	178	27	malhotra	malhotra	PROPN
dti-1332	178	28	drug	drug	PROPN
dti-1332	178	29	target	target	NOUN
dti-1332	178	30	insights	insight	VERB
dti-1332	178	31	2008:3	2008:3	NUM
dti-1332	178	32	target	target	NOUN
dti-1332	178	33	.	.	PUNCT
dti-1332	179	1	this	this	PRON
dti-1332	179	2	is	be	AUX
dti-1332	179	3	done	do	VERB
dti-1332	179	4	using	use	VERB
dti-1332	179	5	a	a	DET
dti-1332	179	6	technique	technique	NOUN
dti-1332	179	7	called	call	VERB
dti-1332	179	8	pseudotyping	pseudotyping	NOUN
dti-1332	179	9	,	,	PUNCT
dti-1332	179	10	which	which	PRON
dti-1332	179	11	involves	involve	VERB
dti-1332	179	12	deletion	deletion	NOUN
dti-1332	179	13	of	of	ADP
dti-1332	179	14	diseasepromoting	diseasepromote	VERB
dti-1332	179	15	genes	gene	NOUN
dti-1332	179	16	and	and	CCONJ
dti-1332	179	17	incorporation	incorporation	NOUN
dti-1332	179	18	of	of	ADP
dti-1332	179	19	glycoproteins	glycoprotein	NOUN
dti-1332	179	20	from	from	ADP
dti-1332	179	21	another	another	DET
dti-1332	179	22	virus	virus	NOUN
dti-1332	179	23	.	.	PUNCT
dti-1332	180	1	this	this	PRON
dti-1332	180	2	helps	help	VERB
dti-1332	180	3	them	they	PRON
dti-1332	180	4	to	to	PART
dti-1332	180	5	effectively	effectively	ADV
dti-1332	180	6	transduce	transduce	VERB
dti-1332	180	7	neurons	neuron	NOUN
dti-1332	180	8	(	(	PUNCT
dti-1332	180	9	mazarakis	mazaraki	NOUN
dti-1332	180	10	et	et	PROPN
dti-1332	180	11	al	al	PROPN
dti-1332	180	12	.	.	PROPN
dti-1332	180	13	2001	2001	NUM
dti-1332	180	14	)	)	PUNCT
dti-1332	180	15	.	.	PUNCT
dti-1332	181	1	though	though	SCONJ
dti-1332	181	2	the	the	DET
dti-1332	181	3	modifi	modifi	NOUN
dti-1332	181	4	cation	cation	NOUN
dti-1332	181	5	of	of	ADP
dti-1332	181	6	retroviruses	retrovirus	NOUN
dti-1332	181	7	has	have	AUX
dti-1332	181	8	delivered	deliver	VERB
dti-1332	181	9	successful	successful	ADJ
dti-1332	181	10	transfection	transfection	NOUN
dti-1332	181	11	studies	study	NOUN
dti-1332	181	12	as	as	ADP
dti-1332	181	13	carriers	carrier	NOUN
dti-1332	181	14	,	,	PUNCT
dti-1332	181	15	the	the	DET
dti-1332	181	16	major	major	ADJ
dti-1332	181	17	risk	risk	NOUN
dti-1332	181	18	lies	lie	VERB
dti-1332	181	19	in	in	ADP
dti-1332	181	20	their	their	PRON
dti-1332	181	21	character	character	NOUN
dti-1332	181	22	to	to	PART
dti-1332	181	23	integrate	integrate	VERB
dti-1332	181	24	their	their	PRON
dti-1332	181	25	genetic	genetic	ADJ
dti-1332	181	26	material	material	NOUN
dti-1332	181	27	with	with	ADP
dti-1332	181	28	the	the	DET
dti-1332	181	29	host	host	NOUN
dti-1332	181	30	genome	genome	NOUN
dti-1332	181	31	,	,	PUNCT
dti-1332	181	32	causing	cause	VERB
dti-1332	181	33	oncogenesis	oncogenesis	NOUN
dti-1332	181	34	.	.	PUNCT
dti-1332	182	1	studies	study	NOUN
dti-1332	182	2	do	do	AUX
dti-1332	182	3	support	support	VERB
dti-1332	182	4	the	the	DET
dti-1332	182	5	activation	activation	NOUN
dti-1332	182	6	of	of	ADP
dti-1332	182	7	an	an	DET
dti-1332	182	8	immune	immune	ADJ
dti-1332	182	9	response	response	NOUN
dti-1332	182	10	against	against	ADP
dti-1332	182	11	viral	viral	ADJ
dti-1332	182	12	vectors	vector	NOUN
dti-1332	182	13	,	,	PUNCT
dti-1332	182	14	nullifying	nullify	VERB
dti-1332	182	15	their	their	PRON
dti-1332	182	16	effect	effect	NOUN
dti-1332	182	17	as	as	ADP
dti-1332	182	18	carriers	carrier	NOUN
dti-1332	182	19	(	(	PUNCT
dti-1332	182	20	peden	peden	PROPN
dti-1332	182	21	et	et	PROPN
dti-1332	182	22	al	al	PROPN
dti-1332	182	23	.	.	PROPN
dti-1332	182	24	2004	2004	NUM
dti-1332	182	25	)	)	PUNCT
dti-1332	182	26	.	.	PUNCT
dti-1332	183	1	viruses	virus	NOUN
dti-1332	183	2	as	as	ADP
dti-1332	183	3	carriers	carrier	NOUN
dti-1332	183	4	when	when	SCONJ
dti-1332	183	5	observed	observe	VERB
dti-1332	183	6	to	to	PART
dti-1332	183	7	increase	increase	VERB
dti-1332	183	8	cellular	cellular	ADJ
dti-1332	183	9	toxicity	toxicity	NOUN
dti-1332	183	10	(	(	PUNCT
dti-1332	183	11	davis	davis	PROPN
dti-1332	183	12	et	et	PROPN
dti-1332	183	13	al	al	PROPN
dti-1332	183	14	.	.	PROPN
dti-1332	183	15	2004	2004	NUM
dti-1332	183	16	)	)	PUNCT
dti-1332	183	17	,	,	PUNCT
dti-1332	183	18	immunological	immunological	ADJ
dti-1332	183	19	complications	complication	NOUN
dti-1332	183	20	(	(	PUNCT
dti-1332	183	21	lu	lu	NOUN
dti-1332	183	22	et	et	PROPN
dti-1332	183	23	al	al	PROPN
dti-1332	183	24	.	.	PROPN
dti-1332	183	25	2005	2005	NUM
dti-1332	183	26	)	)	PUNCT
dti-1332	183	27	and	and	CCONJ
dti-1332	183	28	in	in	ADP
dti-1332	183	29	many	many	ADJ
dti-1332	183	30	cases	case	NOUN
dti-1332	183	31	poor	poor	ADJ
dti-1332	183	32	intracellular	intracellular	ADJ
dti-1332	183	33	uptake	uptake	ADJ
dti-1332	183	34	and	and	CCONJ
dti-1332	183	35	limited	limited	ADJ
dti-1332	183	36	blood	blood	NOUN
dti-1332	183	37	stability	stability	NOUN
dti-1332	183	38	instigated	instigate	VERB
dti-1332	183	39	researchers	researcher	NOUN
dti-1332	183	40	to	to	PART
dti-1332	183	41	develop	develop	VERB
dti-1332	183	42	non	non	ADJ
dti-1332	183	43	-	-	ADJ
dti-1332	183	44	viral	viral	ADJ
dti-1332	183	45	delivery	delivery	NOUN
dti-1332	183	46	mechanisms	mechanism	NOUN
dti-1332	183	47	.	.	PUNCT
dti-1332	184	1	sirnas	sirnas	PROPN
dti-1332	184	2	has	have	AUX
dti-1332	184	3	been	be	AUX
dti-1332	184	4	delivered	deliver	VERB
dti-1332	184	5	to	to	ADP
dti-1332	184	6	the	the	DET
dti-1332	184	7	central	central	ADJ
dti-1332	184	8	nervous	nervous	ADJ
dti-1332	184	9	system	system	NOUN
dti-1332	184	10	both	both	CCONJ
dti-1332	184	11	naked	naked	ADJ
dti-1332	184	12	or	or	CCONJ
dti-1332	184	13	with	with	ADP
dti-1332	184	14	the	the	DET
dti-1332	184	15	help	help	NOUN
dti-1332	184	16	of	of	ADP
dti-1332	184	17	some	some	DET
dti-1332	184	18	transfection	transfection	NOUN
dti-1332	184	19	regeant	regeant	NOUN
dti-1332	184	20	in	in	ADP
dti-1332	184	21	vivo	vivo	NOUN
dti-1332	184	22	targeting	target	VERB
dti-1332	184	23	different	different	ADJ
dti-1332	184	24	molecular	molecular	ADJ
dti-1332	184	25	targets	target	NOUN
dti-1332	184	26	in	in	ADP
dti-1332	184	27	different	different	ADJ
dti-1332	184	28	parts	part	NOUN
dti-1332	184	29	of	of	ADP
dti-1332	184	30	nervous	nervous	ADJ
dti-1332	184	31	system	system	NOUN
dti-1332	184	32	showing	show	VERB
dti-1332	184	33	effective	effective	ADJ
dti-1332	184	34	gene	gene	NOUN
dti-1332	184	35	silencing	silencing	NOUN
dti-1332	184	36	.	.	PUNCT
dti-1332	185	1	direct	direct	ADJ
dti-1332	185	2	doses	dose	NOUN
dti-1332	185	3	of	of	ADP
dti-1332	185	4	sirnas	sirna	NOUN
dti-1332	185	5	administered	administer	VERB
dti-1332	185	6	intrathecally	intrathecally	ADV
dti-1332	185	7	(	(	PUNCT
dti-1332	185	8	dorn	dorn	PROPN
dti-1332	185	9	et	et	PROPN
dti-1332	185	10	al	al	PROPN
dti-1332	185	11	.	.	PROPN
dti-1332	185	12	2004	2004	NUM
dti-1332	185	13	)	)	PUNCT
dti-1332	185	14	or	or	CCONJ
dti-1332	185	15	intracerebro	intracerebro	NOUN
dti-1332	185	16	-	-	PUNCT
dti-1332	185	17	ventricularly	ventricularly	NOUN
dti-1332	185	18	(	(	PUNCT
dti-1332	185	19	thakker	thakker	NOUN
dti-1332	185	20	et	et	PROPN
dti-1332	185	21	al	al	PROPN
dti-1332	185	22	.	.	PROPN
dti-1332	185	23	2004	2004	NUM
dti-1332	185	24	,	,	PUNCT
dti-1332	185	25	2005	2005	NUM
dti-1332	185	26	,	,	PUNCT
dti-1332	185	27	2006	2006	NUM
dti-1332	185	28	)	)	PUNCT
dti-1332	185	29	pose	pose	VERB
dti-1332	185	30	a	a	DET
dti-1332	185	31	widespread	widespread	ADJ
dti-1332	185	32	inhibition	inhibition	NOUN
dti-1332	185	33	of	of	ADP
dti-1332	185	34	molecular	molecular	ADJ
dti-1332	185	35	targets	target	NOUN
dti-1332	185	36	that	that	PRON
dti-1332	185	37	are	be	AUX
dti-1332	185	38	broadly	broadly	ADV
dti-1332	185	39	expressed	express	VERB
dti-1332	185	40	in	in	ADP
dti-1332	185	41	different	different	ADJ
dti-1332	185	42	parts	part	NOUN
dti-1332	185	43	of	of	ADP
dti-1332	185	44	the	the	DET
dti-1332	185	45	brain	brain	NOUN
dti-1332	185	46	that	that	PRON
dti-1332	185	47	may	may	AUX
dti-1332	185	48	lead	lead	VERB
dti-1332	185	49	to	to	ADP
dti-1332	185	50	offtargeting	offtargeting	PROPN
dti-1332	185	51	.	.	PUNCT
dti-1332	186	1	therefore	therefore	ADV
dti-1332	186	2	,	,	PUNCT
dti-1332	186	3	use	use	NOUN
dti-1332	186	4	of	of	ADP
dti-1332	186	5	transfection	transfection	NOUN
dti-1332	186	6	reagents	reagent	NOUN
dti-1332	186	7	was	be	AUX
dti-1332	186	8	encouraged	encourage	VERB
dti-1332	186	9	to	to	PART
dti-1332	186	10	use	use	VERB
dti-1332	186	11	the	the	DET
dti-1332	186	12	dose	dose	NOUN
dti-1332	186	13	in	in	ADP
dti-1332	186	14	less	less	ADJ
dti-1332	186	15	quantity	quantity	NOUN
dti-1332	186	16	and	and	CCONJ
dti-1332	186	17	less	less	ADV
dti-1332	186	18	frequently	frequently	ADV
dti-1332	186	19	.	.	PUNCT
dti-1332	187	1	these	these	DET
dti-1332	187	2	transfection	transfection	NOUN
dti-1332	187	3	reagents	reagent	NOUN
dti-1332	187	4	provide	provide	VERB
dti-1332	187	5	simple	simple	ADJ
dti-1332	187	6	means	mean	NOUN
dti-1332	187	7	of	of	ADP
dti-1332	187	8	gene	gene	NOUN
dti-1332	187	9	silencing	silence	VERB
dti-1332	187	10	using	use	VERB
dti-1332	187	11	sirnas	sirna	NOUN
dti-1332	187	12	.	.	PUNCT
dti-1332	188	1	some	some	PRON
dti-1332	188	2	of	of	ADP
dti-1332	188	3	the	the	DET
dti-1332	188	4	widely	widely	ADV
dti-1332	188	5	used	use	VERB
dti-1332	188	6	transfection	transfection	NOUN
dti-1332	188	7	reagents	reagent	NOUN
dti-1332	188	8	are	be	AUX
dti-1332	188	9	lipofectamine-2000	lipofectamine-2000	ADJ
dti-1332	188	10	,	,	PUNCT
dti-1332	188	11	cellfectine	cellfectine	ADJ
dti-1332	188	12	and	and	CCONJ
dti-1332	188	13	oligofectamine	oligofectamine	VERB
dti-1332	188	14	from	from	ADP
dti-1332	188	15	invitrogen	invitrogen	PROPN
dti-1332	188	16	,	,	PUNCT
dti-1332	188	17	effectene	effectene	NOUN
dti-1332	188	18	from	from	ADP
dti-1332	188	19	qiagen	qiagen	NOUN
dti-1332	188	20	and	and	CCONJ
dti-1332	188	21	siport	siport	NOUN
dti-1332	188	22	-	-	PUNCT
dti-1332	188	23	amine	amine	ADJ
dti-1332	188	24	and	and	CCONJ
dti-1332	188	25	siport	siport	NOUN
dti-1332	188	26	-	-	NOUN
dti-1332	188	27	lipid	lipid	NOUN
dti-1332	188	28	from	from	ADP
dti-1332	188	29	ambion	ambion	NOUN
dti-1332	188	30	.	.	PUNCT
dti-1332	189	1	however	however	ADV
dti-1332	189	2	,	,	PUNCT
dti-1332	189	3	cytoxicity	cytoxicity	NOUN
dti-1332	189	4	caused	cause	VERB
dti-1332	189	5	by	by	ADP
dti-1332	189	6	these	these	DET
dti-1332	189	7	tranfection	tranfection	NOUN
dti-1332	189	8	reagents	reagent	NOUN
dti-1332	189	9	has	have	VERB
dti-1332	189	10	to	to	PART
dti-1332	189	11	be	be	AUX
dti-1332	189	12	taken	take	VERB
dti-1332	189	13	into	into	ADP
dti-1332	189	14	consideration	consideration	NOUN
dti-1332	189	15	before	before	ADP
dti-1332	189	16	going	go	VERB
dti-1332	189	17	into	into	ADP
dti-1332	189	18	clinical	clinical	ADJ
dti-1332	189	19	trials	trial	NOUN
dti-1332	189	20	.	.	PUNCT
dti-1332	190	1	non	non	ADJ
dti-1332	190	2	-	-	ADJ
dti-1332	190	3	viral	viral	ADJ
dti-1332	190	4	mediated	mediate	VERB
dti-1332	190	5	sirna	sirna	PROPN
dti-1332	190	6	delivery	delivery	NOUN
dti-1332	190	7	—	—	PUNCT
dti-1332	190	8	nanoparticles	nanoparticle	NOUN
dti-1332	190	9	considering	consider	VERB
dti-1332	190	10	above	above	ADP
dti-1332	190	11	factors	factor	NOUN
dti-1332	190	12	pertaining	pertain	VERB
dti-1332	190	13	to	to	ADP
dti-1332	190	14	delivery	delivery	NOUN
dti-1332	190	15	and	and	CCONJ
dti-1332	190	16	in	in	ADP
dti-1332	190	17	order	order	NOUN
dti-1332	190	18	to	to	PART
dti-1332	190	19	reduce	reduce	VERB
dti-1332	190	20	cytotoxicity	cytotoxicity	NOUN
dti-1332	190	21	,	,	PUNCT
dti-1332	190	22	poor	poor	ADJ
dti-1332	190	23	intracellular	intracellular	ADJ
dti-1332	190	24	uptake	uptake	NOUN
dti-1332	190	25	,	,	PUNCT
dti-1332	190	26	limited	limited	ADJ
dti-1332	190	27	blood	blood	NOUN
dti-1332	190	28	stability	stability	NOUN
dti-1332	190	29	and	and	CCONJ
dti-1332	190	30	off	off	ADP
dti-1332	190	31	-	-	PUNCT
dti-1332	190	32	target	target	NOUN
dti-1332	190	33	effects	effect	NOUN
dti-1332	190	34	,	,	PUNCT
dti-1332	190	35	cationic	cationic	ADJ
dti-1332	190	36	plexes	plexe	NOUN
dti-1332	190	37	(	(	PUNCT
dti-1332	190	38	a	a	DET
dti-1332	190	39	positively	positively	ADV
dti-1332	190	40	charged	charge	VERB
dti-1332	190	41	vehicle	vehicle	NOUN
dti-1332	190	42	that	that	PRON
dti-1332	190	43	can	can	AUX
dti-1332	190	44	carry	carry	VERB
dti-1332	190	45	a	a	DET
dti-1332	190	46	negatively	negatively	ADV
dti-1332	190	47	charged	charge	VERB
dti-1332	190	48	therapeutic	therapeutic	ADJ
dti-1332	190	49	molecule	molecule	NOUN
dti-1332	190	50	into	into	ADP
dti-1332	190	51	the	the	DET
dti-1332	190	52	target	target	NOUN
dti-1332	190	53	cell	cell	NOUN
dti-1332	190	54	)	)	PUNCT
dti-1332	190	55	can	can	AUX
dti-1332	190	56	be	be	AUX
dti-1332	190	57	used	use	VERB
dti-1332	190	58	for	for	ADP
dti-1332	190	59	sirna	sirna	PROPN
dti-1332	190	60	transfection	transfection	NOUN
dti-1332	190	61	,	,	PUNCT
dti-1332	190	62	which	which	PRON
dti-1332	190	63	will	will	AUX
dti-1332	190	64	also	also	ADV
dti-1332	190	65	address	address	VERB
dti-1332	190	66	concerns	concern	NOUN
dti-1332	190	67	of	of	ADP
dti-1332	190	68	safety	safety	NOUN
dti-1332	190	69	and	and	CCONJ
dti-1332	190	70	immunogenicity	immunogenicity	NOUN
dti-1332	190	71	of	of	ADP
dti-1332	190	72	the	the	DET
dti-1332	190	73	sirnas	sirna	NOUN
dti-1332	190	74	.	.	PUNCT
dti-1332	191	1	these	these	DET
dti-1332	191	2	cationic	cationic	ADJ
dti-1332	191	3	polymers	polymer	NOUN
dti-1332	191	4	exist	exist	VERB
dti-1332	191	5	in	in	ADP
dti-1332	191	6	the	the	DET
dti-1332	191	7	range	range	NOUN
dti-1332	191	8	of	of	ADP
dti-1332	191	9	0.1	0.1	NUM
dti-1332	191	10	nanometers	nanometer	NOUN
dti-1332	191	11	to	to	ADP
dti-1332	191	12	100	100	NUM
dti-1332	191	13	nanometers	nanometer	NOUN
dti-1332	191	14	(	(	PUNCT
dti-1332	191	15	schiffelers	schiffeler	NOUN
dti-1332	191	16	et	et	PROPN
dti-1332	191	17	al	al	PROPN
dti-1332	191	18	.	.	PROPN
dti-1332	191	19	2004	2004	NUM
dti-1332	191	20	)	)	PUNCT
dti-1332	191	21	.	.	PUNCT
dti-1332	192	1	they	they	PRON
dti-1332	192	2	are	be	AUX
dti-1332	192	3	not	not	PART
dti-1332	192	4	only	only	ADV
dti-1332	192	5	small	small	ADJ
dti-1332	192	6	,	,	PUNCT
dti-1332	192	7	but	but	CCONJ
dti-1332	192	8	have	have	VERB
dti-1332	192	9	entirely	entirely	ADV
dti-1332	192	10	different	different	ADJ
dti-1332	192	11	physical	physical	ADJ
dti-1332	192	12	and	and	CCONJ
dti-1332	192	13	chemical	chemical	NOUN
dti-1332	192	14	properties	property	NOUN
dti-1332	192	15	than	than	ADP
dti-1332	192	16	their	their	PRON
dti-1332	192	17	more	more	ADJ
dti-1332	192	18	macro	macro	ADJ
dti-1332	192	19	versions	version	NOUN
dti-1332	192	20	.	.	PUNCT
dti-1332	193	1	they	they	PRON
dti-1332	193	2	form	form	VERB
dti-1332	193	3	a	a	DET
dti-1332	193	4	neutral	neutral	ADJ
dti-1332	193	5	complex	complex	NOUN
dti-1332	193	6	when	when	SCONJ
dti-1332	193	7	encapsulating	encapsulate	VERB
dti-1332	193	8	a	a	DET
dti-1332	193	9	negatively	negatively	ADV
dti-1332	193	10	charged	charge	VERB
dti-1332	193	11	molecule	molecule	NOUN
dti-1332	193	12	that	that	PRON
dti-1332	193	13	can	can	AUX
dti-1332	193	14	readily	readily	ADV
dti-1332	193	15	be	be	AUX
dti-1332	193	16	taken	take	VERB
dti-1332	193	17	up	up	ADP
dti-1332	193	18	by	by	ADP
dti-1332	193	19	the	the	DET
dti-1332	193	20	cells	cell	NOUN
dti-1332	193	21	(	(	PUNCT
dti-1332	193	22	neuronal	neuronal	ADJ
dti-1332	193	23	)	)	PUNCT
dti-1332	193	24	through	through	ADP
dti-1332	193	25	endocytosis	endocytosis	NOUN
dti-1332	193	26	without	without	ADP
dti-1332	193	27	showing	show	VERB
dti-1332	193	28	any	any	DET
dti-1332	193	29	cytotoxic	cytotoxic	ADJ
dti-1332	193	30	effects	effect	NOUN
dti-1332	193	31	caused	cause	VERB
dti-1332	193	32	due	due	ADJ
dti-1332	193	33	to	to	ADP
dti-1332	193	34	cationic	cationic	ADJ
dti-1332	193	35	charge	charge	NOUN
dti-1332	193	36	.	.	PUNCT
dti-1332	194	1	cationic	cationic	ADJ
dti-1332	194	2	nanoplexes	nanoplexe	NOUN
dti-1332	194	3	used	use	VERB
dti-1332	194	4	for	for	ADP
dti-1332	194	5	sirna	sirna	PROPN
dti-1332	194	6	delivery	delivery	NOUN
dti-1332	194	7	are	be	AUX
dti-1332	194	8	much	much	ADV
dti-1332	194	9	smaller	small	ADJ
dti-1332	194	10	than	than	ADP
dti-1332	194	11	human	human	ADJ
dti-1332	194	12	cells	cell	NOUN
dti-1332	194	13	(	(	PUNCT
dti-1332	194	14	10,000–20,000	10,000–20,000	NUM
dti-1332	194	15	nm	nm	NOUN
dti-1332	194	16	in	in	ADP
dti-1332	194	17	diameter	diameter	NOUN
dti-1332	194	18	)	)	PUNCT
dti-1332	194	19	and	and	CCONJ
dti-1332	194	20	organelles	organelle	NOUN
dti-1332	194	21	but	but	CCONJ
dti-1332	194	22	are	be	AUX
dti-1332	194	23	similar	similar	ADJ
dti-1332	194	24	to	to	ADP
dti-1332	194	25	biological	biological	ADJ
dti-1332	194	26	macromolecules	macromolecule	NOUN
dti-1332	194	27	like	like	ADP
dti-1332	194	28	enzymes	enzyme	NOUN
dti-1332	194	29	and	and	CCONJ
dti-1332	194	30	receptors	receptor	NOUN
dti-1332	194	31	.	.	PUNCT
dti-1332	195	1	these	these	DET
dti-1332	195	2	nanoparticles	nanoparticle	NOUN
dti-1332	195	3	are	be	AUX
dti-1332	195	4	widely	widely	ADV
dti-1332	195	5	being	be	AUX
dti-1332	195	6	accepted	accept	VERB
dti-1332	195	7	as	as	ADP
dti-1332	195	8	an	an	DET
dti-1332	195	9	alternative	alternative	ADJ
dti-1332	195	10	approach	approach	NOUN
dti-1332	195	11	to	to	ADP
dti-1332	195	12	gene	gene	NOUN
dti-1332	195	13	delivery	delivery	NOUN
dti-1332	195	14	and	and	CCONJ
dti-1332	195	15	can	can	AUX
dti-1332	195	16	be	be	AUX
dti-1332	195	17	developed	develop	VERB
dti-1332	195	18	from	from	ADP
dti-1332	195	19	cyclodextrin	cyclodextrin	NOUN
dti-1332	195	20	polycations	polycation	NOUN
dti-1332	195	21	,	,	PUNCT
dti-1332	195	22	polyl	polyl	NOUN
dti-1332	195	23	-	-	PUNCT
dti-1332	195	24	lysine	lysine	NOUN
dti-1332	195	25	,	,	PUNCT
dti-1332	195	26	polyamidoamines	polyamidoamine	NOUN
dti-1332	195	27	,	,	PUNCT
dti-1332	195	28	chitosan	chitosan	NOUN
dti-1332	195	29	,	,	PUNCT
dti-1332	195	30	quantum	quantum	ADJ
dti-1332	195	31	dots	dot	NOUN
dti-1332	195	32	and	and	CCONJ
dti-1332	195	33	liposomes	liposome	NOUN
dti-1332	195	34	to	to	PART
dti-1332	195	35	deliver	deliver	VERB
dti-1332	195	36	sirna	sirna	PROPN
dti-1332	195	37	for	for	ADP
dti-1332	195	38	on	on	ADP
dti-1332	195	39	-	-	PUNCT
dti-1332	195	40	target	target	NOUN
dti-1332	195	41	gene	gene	NOUN
dti-1332	195	42	silencing	silence	VERB
dti-1332	195	43	(	(	PUNCT
dti-1332	195	44	mcneil	mcneil	PROPN
dti-1332	195	45	,	,	PUNCT
dti-1332	195	46	2005	2005	NUM
dti-1332	195	47	)	)	PUNCT
dti-1332	195	48	.	.	PUNCT
dti-1332	196	1	these	these	DET
dti-1332	196	2	particles	particle	NOUN
dti-1332	196	3	have	have	VERB
dti-1332	196	4	to	to	PART
dti-1332	196	5	overcome	overcome	VERB
dti-1332	196	6	many	many	ADJ
dti-1332	196	7	anatomical	anatomical	ADJ
dti-1332	196	8	,	,	PUNCT
dti-1332	196	9	biophysical	biophysical	ADJ
dti-1332	196	10	and	and	CCONJ
dti-1332	196	11	physiological	physiological	ADJ
dti-1332	196	12	barriers	barrier	NOUN
dti-1332	196	13	that	that	PRON
dti-1332	196	14	the	the	DET
dti-1332	196	15	body	body	NOUN
dti-1332	196	16	stages	stage	VERB
dti-1332	196	17	against	against	ADP
dti-1332	196	18	a	a	DET
dti-1332	196	19	standard	standard	ADJ
dti-1332	196	20	intervention	intervention	NOUN
dti-1332	196	21	such	such	ADJ
dti-1332	196	22	as	as	ADP
dti-1332	196	23	administration	administration	NOUN
dti-1332	196	24	of	of	ADP
dti-1332	196	25	drugs	drug	NOUN
dti-1332	196	26	or	or	CCONJ
dti-1332	196	27	contrast	contrast	VERB
dti-1332	196	28	agents	agent	NOUN
dti-1332	196	29	(	(	PUNCT
dti-1332	196	30	molas	mola	NOUN
dti-1332	196	31	et	et	PROPN
dti-1332	196	32	al	al	PROPN
dti-1332	196	33	.	.	PROPN
dti-1332	196	34	2003	2003	NUM
dti-1332	196	35	)	)	PUNCT
dti-1332	196	36	(	(	PUNCT
dti-1332	196	37	fig	fig	NOUN
dti-1332	196	38	.	.	PUNCT
dti-1332	196	39	4	4	NUM
dti-1332	196	40	)	)	PUNCT
dti-1332	196	41	.	.	PUNCT
dti-1332	197	1	besides	besides	SCONJ
dti-1332	197	2	bypassing	bypass	VERB
dti-1332	197	3	these	these	DET
dti-1332	197	4	barriers	barrier	NOUN
dti-1332	197	5	,	,	PUNCT
dti-1332	197	6	the	the	DET
dti-1332	197	7	physiology	physiology	NOUN
dti-1332	197	8	of	of	ADP
dti-1332	197	9	nanoparticles	nanoparticle	NOUN
dti-1332	197	10	is	be	AUX
dti-1332	197	11	also	also	ADV
dti-1332	197	12	to	to	PART
dti-1332	197	13	be	be	AUX
dti-1332	197	14	considered	consider	VERB
dti-1332	197	15	,	,	PUNCT
dti-1332	197	16	like	like	ADP
dti-1332	197	17	the	the	DET
dti-1332	197	18	size	size	NOUN
dti-1332	197	19	of	of	ADP
dti-1332	197	20	the	the	DET
dti-1332	197	21	carrier	carrier	NOUN
dti-1332	197	22	,	,	PUNCT
dti-1332	197	23	which	which	PRON
dti-1332	197	24	should	should	AUX
dti-1332	197	25	be	be	AUX
dti-1332	197	26	in	in	ADP
dti-1332	197	27	accordance	accordance	NOUN
dti-1332	197	28	with	with	ADP
dti-1332	197	29	type	type	NOUN
dti-1332	197	30	of	of	ADP
dti-1332	197	31	tissue	tissue	NOUN
dti-1332	197	32	or	or	CCONJ
dti-1332	197	33	cell	cell	NOUN
dti-1332	197	34	to	to	PART
dti-1332	197	35	be	be	AUX
dti-1332	197	36	targeted	target	VERB
dti-1332	197	37	as	as	ADV
dti-1332	197	38	well	well	ADV
dti-1332	197	39	as	as	ADP
dti-1332	197	40	its	its	PRON
dti-1332	197	41	stability	stability	NOUN
dti-1332	197	42	and	and	CCONJ
dti-1332	197	43	safety	safety	NOUN
dti-1332	197	44	.	.	PUNCT
dti-1332	198	1	the	the	DET
dti-1332	198	2	fi	fi	NOUN
dti-1332	198	3	nal	nal	ADJ
dti-1332	198	4	success	success	NOUN
dti-1332	198	5	of	of	ADP
dti-1332	198	6	a	a	DET
dti-1332	198	7	drug	drug	NOUN
dti-1332	198	8	/	/	SYM
dti-1332	198	9	gene	gene	NOUN
dti-1332	198	10	delivery	delivery	NOUN
dti-1332	198	11	system	system	NOUN
dti-1332	198	12	lies	lie	VERB
dti-1332	198	13	in	in	ADP
dti-1332	198	14	the	the	DET
dti-1332	198	15	accurate	accurate	ADJ
dti-1332	198	16	delivery	delivery	NOUN
dti-1332	198	17	of	of	ADP
dti-1332	198	18	nanoparticles	nanoparticle	NOUN
dti-1332	198	19	to	to	ADP
dti-1332	198	20	the	the	DET
dti-1332	198	21	desired	desire	VERB
dti-1332	198	22	targeted	target	VERB
dti-1332	198	23	location	location	NOUN
dti-1332	198	24	.	.	PUNCT
dti-1332	199	1	limitations	limitation	NOUN
dti-1332	199	2	of	of	ADP
dti-1332	199	3	nanoparticles	nanoparticle	NOUN
dti-1332	199	4	for	for	ADP
dti-1332	199	5	sirna	sirna	PROPN
dti-1332	199	6	delivery	delivery	NOUN
dti-1332	199	7	biodistribution	biodistribution	NOUN
dti-1332	199	8	or	or	CCONJ
dti-1332	199	9	bioavailability	bioavailability	NOUN
dti-1332	199	10	and	and	CCONJ
dti-1332	199	11	toxicity	toxicity	NOUN
dti-1332	199	12	of	of	ADP
dti-1332	199	13	the	the	DET
dti-1332	199	14	particle	particle	NOUN
dti-1332	199	15	along	along	ADP
dti-1332	199	16	with	with	ADP
dti-1332	199	17	its	its	PRON
dti-1332	199	18	payload	payload	NOUN
dti-1332	199	19	go	go	VERB
dti-1332	199	20	hand	hand	NOUN
dti-1332	199	21	in	in	ADP
dti-1332	199	22	hand	hand	NOUN
dti-1332	199	23	as	as	SCONJ
dti-1332	199	24	the	the	DET
dti-1332	199	25	factors	factor	NOUN
dti-1332	199	26	which	which	PRON
dti-1332	199	27	govern	govern	VERB
dti-1332	199	28	them	they	PRON
dti-1332	199	29	are	be	AUX
dti-1332	199	30	interdependent	interdependent	ADJ
dti-1332	199	31	on	on	ADP
dti-1332	199	32	each	each	DET
dti-1332	199	33	other	other	ADJ
dti-1332	199	34	.	.	PUNCT
dti-1332	200	1	the	the	DET
dti-1332	200	2	major	major	ADJ
dti-1332	200	3	factors	factor	NOUN
dti-1332	200	4	are	be	AUX
dti-1332	200	5	size	size	NOUN
dti-1332	200	6	,	,	PUNCT
dti-1332	200	7	shape	shape	NOUN
dti-1332	200	8	and	and	CCONJ
dti-1332	200	9	surface	surface	NOUN
dti-1332	200	10	charge	charge	NOUN
dti-1332	200	11	(	(	PUNCT
dti-1332	200	12	zeta	zeta	NOUN
dti-1332	200	13	potential	potential	NOUN
dti-1332	200	14	)	)	PUNCT
dti-1332	200	15	of	of	ADP
dti-1332	200	16	nanoparticles	nanoparticle	NOUN
dti-1332	200	17	(	(	PUNCT
dti-1332	200	18	labhasetwar	labhasetwar	NOUN
dti-1332	200	19	,	,	PUNCT
dti-1332	200	20	2005	2005	NUM
dti-1332	200	21	)	)	PUNCT
dti-1332	200	22	.	.	PUNCT
dti-1332	201	1	an	an	DET
dti-1332	201	2	encapsulated	encapsulate	VERB
dti-1332	201	3	drug	drug	NOUN
dti-1332	201	4	can	can	AUX
dti-1332	201	5	only	only	ADV
dti-1332	201	6	be	be	AUX
dti-1332	201	7	released	release	VERB
dti-1332	201	8	from	from	ADP
dti-1332	201	9	the	the	DET
dti-1332	201	10	nanoparticle	nanoparticle	NOUN
dti-1332	201	11	when	when	SCONJ
dti-1332	201	12	it	it	PRON
dti-1332	201	13	degrades	degrade	VERB
dti-1332	201	14	and	and	CCONJ
dti-1332	201	15	releases	release	VERB
dti-1332	201	16	the	the	DET
dti-1332	201	17	drug	drug	NOUN
dti-1332	201	18	at	at	ADP
dti-1332	201	19	the	the	DET
dti-1332	201	20	target	target	NOUN
dti-1332	201	21	site	site	NOUN
dti-1332	201	22	.	.	PUNCT
dti-1332	202	1	this	this	PRON
dti-1332	202	2	refers	refer	VERB
dti-1332	202	3	to	to	ADP
dti-1332	202	4	the	the	DET
dti-1332	202	5	biodistribution	biodistribution	NOUN
dti-1332	202	6	aspect	aspect	NOUN
dti-1332	202	7	and	and	CCONJ
dti-1332	202	8	the	the	DET
dti-1332	202	9	removal	removal	NOUN
dti-1332	202	10	of	of	ADP
dti-1332	202	11	these	these	DET
dti-1332	202	12	degraded	degraded	ADJ
dti-1332	202	13	particles	particle	NOUN
dti-1332	202	14	from	from	ADP
dti-1332	202	15	the	the	DET
dti-1332	202	16	body	body	NOUN
dti-1332	202	17	with	with	ADP
dti-1332	202	18	minimal	minimal	ADJ
dti-1332	202	19	toxicity	toxicity	NOUN
dti-1332	202	20	effect	effect	NOUN
dti-1332	202	21	.	.	PUNCT
dti-1332	203	1	the	the	DET
dti-1332	203	2	purpose	purpose	NOUN
dti-1332	203	3	of	of	ADP
dti-1332	203	4	using	use	VERB
dti-1332	203	5	nanoparticles	nanoparticle	NOUN
dti-1332	203	6	gets	get	AUX
dti-1332	203	7	defeated	defeat	VERB
dti-1332	203	8	if	if	SCONJ
dti-1332	203	9	they	they	PRON
dti-1332	203	10	stay	stay	VERB
dti-1332	203	11	inside	inside	ADP
dti-1332	203	12	the	the	DET
dti-1332	203	13	body	body	NOUN
dti-1332	203	14	,	,	PUNCT
dti-1332	203	15	causing	cause	VERB
dti-1332	203	16	toxicity	toxicity	NOUN
dti-1332	203	17	to	to	ADP
dti-1332	203	18	the	the	DET
dti-1332	203	19	organs	organ	NOUN
dti-1332	203	20	in	in	ADP
dti-1332	203	21	the	the	DET
dti-1332	203	22	vicinity	vicinity	NOUN
dti-1332	203	23	or	or	CCONJ
dti-1332	203	24	are	be	AUX
dti-1332	203	25	carried	carry	VERB
dti-1332	203	26	to	to	ADP
dti-1332	203	27	the	the	DET
dti-1332	203	28	places	place	NOUN
dti-1332	203	29	where	where	SCONJ
dti-1332	203	30	they	they	PRON
dti-1332	203	31	are	be	AUX
dti-1332	203	32	not	not	PART
dti-1332	203	33	required	require	VERB
dti-1332	203	34	and	and	CCONJ
dti-1332	203	35	thus	thus	ADV
dti-1332	203	36	cause	cause	VERB
dti-1332	203	37	undesired	undesired	ADJ
dti-1332	203	38	sideeffects	sideeffect	NOUN
dti-1332	203	39	.	.	PUNCT
dti-1332	204	1	therefore	therefore	ADV
dti-1332	204	2	,	,	PUNCT
dti-1332	204	3	it	it	PRON
dti-1332	204	4	is	be	AUX
dti-1332	204	5	preferable	preferable	ADJ
dti-1332	204	6	to	to	PART
dti-1332	204	7	use	use	VERB
dti-1332	204	8	natural	natural	ADJ
dti-1332	204	9	materials	material	NOUN
dti-1332	204	10	than	than	ADP
dti-1332	204	11	synthetic	synthetic	ADJ
dti-1332	204	12	ones	one	NOUN
dti-1332	204	13	to	to	PART
dti-1332	204	14	develop	develop	VERB
dti-1332	204	15	nanoparticles	nanoparticle	NOUN
dti-1332	204	16	.	.	PUNCT
dti-1332	205	1	natural	natural	ADJ
dti-1332	205	2	materials	material	NOUN
dti-1332	205	3	pose	pose	VERB
dti-1332	205	4	less	less	ADV
dti-1332	205	5	negative	negative	ADJ
dti-1332	205	6	impact	impact	NOUN
dti-1332	205	7	111	111	NUM
dti-1332	205	8	recent	recent	ADJ
dti-1332	205	9	advancements	advancement	NOUN
dti-1332	205	10	in	in	ADP
dti-1332	205	11	targeted	target	VERB
dti-1332	205	12	delivery	delivery	NOUN
dti-1332	205	13	of	of	ADP
dti-1332	205	14	therapeutic	therapeutic	ADJ
dti-1332	205	15	molecules	molecule	NOUN
dti-1332	205	16	drug	drug	NOUN
dti-1332	205	17	target	target	NOUN
dti-1332	205	18	insights	insight	NOUN
dti-1332	205	19	2008:3	2008:3	NUM
dti-1332	205	20	pertaining	pertain	VERB
dti-1332	205	21	to	to	ADP
dti-1332	205	22	toxicity	toxicity	NOUN
dti-1332	205	23	and	and	CCONJ
dti-1332	205	24	are	be	AUX
dti-1332	205	25	believed	believe	VERB
dti-1332	205	26	to	to	PART
dti-1332	205	27	be	be	AUX
dti-1332	205	28	degraded	degrade	VERB
dti-1332	205	29	once	once	ADV
dti-1332	205	30	after	after	ADP
dti-1332	205	31	releasing	release	VERB
dti-1332	205	32	their	their	PRON
dti-1332	205	33	payload	payload	NOUN
dti-1332	205	34	.	.	PUNCT
dti-1332	206	1	size	size	NOUN
dti-1332	206	2	highly	highly	ADV
dti-1332	206	3	determines	determine	VERB
dti-1332	206	4	the	the	DET
dti-1332	206	5	bioavailability	bioavailability	NOUN
dti-1332	206	6	of	of	ADP
dti-1332	206	7	the	the	DET
dti-1332	206	8	nanoparticle	nanoparticle	NOUN
dti-1332	206	9	.	.	PUNCT
dti-1332	207	1	the	the	DET
dti-1332	207	2	larger	large	ADJ
dti-1332	207	3	sized	sized	ADJ
dti-1332	207	4	nanoparticles	nanoparticle	NOUN
dti-1332	207	5	are	be	AUX
dti-1332	207	6	more	more	ADV
dti-1332	207	7	attracted	attract	VERB
dti-1332	207	8	by	by	ADP
dti-1332	207	9	the	the	DET
dti-1332	207	10	phagocytes	phagocytes	PROPN
dti-1332	207	11	and	and	CCONJ
dti-1332	207	12	are	be	AUX
dti-1332	207	13	cleared	clear	VERB
dti-1332	207	14	from	from	ADP
dti-1332	207	15	the	the	DET
dti-1332	207	16	system	system	NOUN
dti-1332	207	17	,	,	PUNCT
dti-1332	207	18	though	though	SCONJ
dti-1332	207	19	the	the	DET
dti-1332	207	20	clearance	clearance	NOUN
dti-1332	207	21	time	time	NOUN
dti-1332	207	22	also	also	ADV
dti-1332	207	23	depends	depend	VERB
dti-1332	207	24	on	on	ADP
dti-1332	207	25	the	the	DET
dti-1332	207	26	surface	surface	NOUN
dti-1332	207	27	charge	charge	NOUN
dti-1332	207	28	.	.	PUNCT
dti-1332	208	1	it	it	PRON
dti-1332	208	2	has	have	AUX
dti-1332	208	3	also	also	ADV
dti-1332	208	4	been	be	AUX
dti-1332	208	5	observed	observe	VERB
dti-1332	208	6	that	that	SCONJ
dti-1332	208	7	smaller	small	ADJ
dti-1332	208	8	nanoparticles	nanoparticle	NOUN
dti-1332	208	9	can	can	AUX
dti-1332	208	10	permeate	permeate	VERB
dti-1332	208	11	faster	fast	ADV
dti-1332	208	12	—	—	PUNCT
dti-1332	208	13	a	a	DET
dti-1332	208	14	nanoparticle	nanoparticle	NOUN
dti-1332	208	15	of	of	ADP
dti-1332	208	16	size	size	NOUN
dti-1332	208	17	14	14	NUM
dti-1332	208	18	nm	nm	NOUN
dti-1332	208	19	takes	take	VERB
dti-1332	208	20	2	2	NUM
dti-1332	208	21	minutes	minute	NOUN
dti-1332	208	22	to	to	PART
dti-1332	208	23	pass	pass	VERB
dti-1332	208	24	through	through	ADP
dti-1332	208	25	whereas	whereas	SCONJ
dti-1332	208	26	a	a	DET
dti-1332	208	27	particle	particle	NOUN
dti-1332	208	28	of	of	ADP
dti-1332	208	29	size	size	NOUN
dti-1332	208	30	415	415	NUM
dti-1332	208	31	nm	nm	NOUN
dti-1332	208	32	takes	take	VERB
dti-1332	208	33	30	30	NUM
dti-1332	208	34	minutes	minute	NOUN
dti-1332	208	35	(	(	PUNCT
dti-1332	208	36	szentkuti	szentkuti	NOUN
dti-1332	208	37	,	,	PUNCT
dti-1332	208	38	1997	1997	NUM
dti-1332	208	39	)	)	PUNCT
dti-1332	208	40	.	.	PUNCT
dti-1332	209	1	size	size	NOUN
dti-1332	209	2	of	of	ADP
dti-1332	209	3	a	a	DET
dti-1332	209	4	nanoparticle	nanoparticle	NOUN
dti-1332	209	5	varies	vary	VERB
dti-1332	209	6	at	at	ADP
dti-1332	209	7	the	the	DET
dti-1332	209	8	time	time	NOUN
dti-1332	209	9	of	of	ADP
dti-1332	209	10	synthesis	synthesis	NOUN
dti-1332	209	11	.	.	PUNCT
dti-1332	210	1	it	it	PRON
dti-1332	210	2	also	also	ADV
dti-1332	210	3	depends	depend	VERB
dti-1332	210	4	on	on	ADP
dti-1332	210	5	different	different	ADJ
dti-1332	210	6	surfactants	surfactant	NOUN
dti-1332	210	7	and	and	CCONJ
dti-1332	210	8	stabilizers	stabilizer	NOUN
dti-1332	210	9	used	use	VERB
dti-1332	210	10	over	over	ADP
dti-1332	210	11	its	its	PRON
dti-1332	210	12	surface	surface	NOUN
dti-1332	210	13	to	to	PART
dti-1332	210	14	make	make	VERB
dti-1332	210	15	it	it	PRON
dti-1332	210	16	more	more	ADV
dti-1332	210	17	biocompatible	biocompatible	ADJ
dti-1332	210	18	and	and	CCONJ
dti-1332	210	19	bioavailable	bioavailable	ADJ
dti-1332	210	20	.	.	PUNCT
dti-1332	211	1	while	while	SCONJ
dti-1332	211	2	encapsulating	encapsulate	VERB
dti-1332	211	3	the	the	DET
dti-1332	211	4	therapeutic	therapeutic	ADJ
dti-1332	211	5	molecule	molecule	NOUN
dti-1332	211	6	,	,	PUNCT
dti-1332	211	7	the	the	DET
dti-1332	211	8	size	size	NOUN
dti-1332	211	9	of	of	ADP
dti-1332	211	10	the	the	DET
dti-1332	211	11	particle	particle	NOUN
dti-1332	211	12	slightly	slightly	ADV
dti-1332	211	13	increases	increase	NOUN
dti-1332	211	14	,	,	PUNCT
dti-1332	211	15	likewise	likewise	ADV
dti-1332	211	16	shape	shape	NOUN
dti-1332	211	17	of	of	ADP
dti-1332	211	18	the	the	DET
dti-1332	211	19	particle	particle	NOUN
dti-1332	211	20	also	also	ADV
dti-1332	211	21	changes	change	VERB
dti-1332	211	22	.	.	PUNCT
dti-1332	212	1	though	though	ADV
dti-1332	212	2	,	,	PUNCT
dti-1332	212	3	shape	shape	NOUN
dti-1332	212	4	never	never	ADV
dti-1332	212	5	remains	remain	VERB
dti-1332	212	6	constant	constant	ADJ
dti-1332	212	7	but	but	CCONJ
dti-1332	212	8	is	be	AUX
dti-1332	212	9	an	an	DET
dti-1332	212	10	important	important	ADJ
dti-1332	212	11	factor	factor	NOUN
dti-1332	212	12	to	to	PART
dti-1332	212	13	maintain	maintain	VERB
dti-1332	212	14	the	the	DET
dti-1332	212	15	integrity	integrity	NOUN
dti-1332	212	16	of	of	ADP
dti-1332	212	17	the	the	DET
dti-1332	212	18	particle	particle	NOUN
dti-1332	212	19	.	.	PUNCT
dti-1332	213	1	factors	factor	NOUN
dti-1332	213	2	like	like	ADP
dti-1332	213	3	dilution	dilution	NOUN
dti-1332	213	4	,	,	PUNCT
dti-1332	213	5	temperature	temperature	NOUN
dti-1332	213	6	,	,	PUNCT
dti-1332	213	7	ph	ph	ADJ
dti-1332	213	8	,	,	PUNCT
dti-1332	213	9	purifi	purifi	ADJ
dti-1332	213	10	cation	cation	NOUN
dti-1332	213	11	,	,	PUNCT
dti-1332	213	12	surfactants	surfactant	NOUN
dti-1332	213	13	/	/	SYM
dti-1332	213	14	emulsifi	emulsifi	NOUN
dti-1332	213	15	ers	er	NOUN
dti-1332	213	16	used	use	VERB
dti-1332	213	17	and	and	CCONJ
dti-1332	213	18	interaction	interaction	NOUN
dti-1332	213	19	with	with	ADP
dti-1332	213	20	blood	blood	NOUN
dti-1332	213	21	proteins	protein	NOUN
dti-1332	213	22	have	have	VERB
dti-1332	213	23	a	a	DET
dti-1332	213	24	major	major	ADJ
dti-1332	213	25	role	role	NOUN
dti-1332	213	26	in	in	ADP
dti-1332	213	27	changing	change	VERB
dti-1332	213	28	the	the	DET
dti-1332	213	29	average	average	ADJ
dti-1332	213	30	size	size	NOUN
dti-1332	213	31	and	and	CCONJ
dti-1332	213	32	shape	shape	NOUN
dti-1332	213	33	of	of	ADP
dti-1332	213	34	the	the	DET
dti-1332	213	35	particle	particle	NOUN
dti-1332	213	36	(	(	PUNCT
dti-1332	213	37	heydenreich	heydenreich	X
dti-1332	213	38	et	et	PROPN
dti-1332	213	39	al	al	PROPN
dti-1332	213	40	.	.	PROPN
dti-1332	213	41	2003	2003	NUM
dti-1332	213	42	;	;	PUNCT
dti-1332	213	43	dong	dong	PROPN
dti-1332	213	44	and	and	CCONJ
dti-1332	213	45	feng	feng	PROPN
dti-1332	213	46	,	,	PUNCT
dti-1332	213	47	2004	2004	NUM
dti-1332	213	48	;	;	PUNCT
dti-1332	213	49	neradovic	neradovic	PROPN
dti-1332	213	50	et	et	PROPN
dti-1332	213	51	al	al	PROPN
dti-1332	213	52	.	.	PROPN
dti-1332	213	53	2004	2004	NUM
dti-1332	213	54	)	)	PUNCT
dti-1332	213	55	.	.	PUNCT
dti-1332	214	1	it	it	PRON
dti-1332	214	2	is	be	AUX
dti-1332	214	3	always	always	ADV
dti-1332	214	4	preferred	prefer	VERB
dti-1332	214	5	for	for	SCONJ
dti-1332	214	6	a	a	DET
dti-1332	214	7	particle	particle	NOUN
dti-1332	214	8	to	to	PART
dti-1332	214	9	be	be	AUX
dti-1332	214	10	fl	fl	NUM
dti-1332	214	11	exible	exible	ADJ
dti-1332	214	12	enough	enough	ADV
dti-1332	214	13	or	or	CCONJ
dti-1332	214	14	deformable	deformable	ADJ
dti-1332	214	15	so	so	SCONJ
dti-1332	214	16	that	that	SCONJ
dti-1332	214	17	it	it	PRON
dti-1332	214	18	can	can	AUX
dti-1332	214	19	enter	enter	VERB
dti-1332	214	20	and	and	CCONJ
dti-1332	214	21	cross	cross	VERB
dti-1332	214	22	through	through	ADP
dti-1332	214	23	the	the	DET
dti-1332	214	24	fenestrations	fenestration	NOUN
dti-1332	214	25	like	like	ADP
dti-1332	214	26	blood	blood	NOUN
dti-1332	214	27	cells	cell	NOUN
dti-1332	214	28	.	.	PUNCT
dti-1332	215	1	cytotoxicity	cytotoxicity	NOUN
dti-1332	215	2	is	be	AUX
dti-1332	215	3	induced	induce	VERB
dti-1332	215	4	mainly	mainly	ADV
dti-1332	215	5	by	by	ADP
dti-1332	215	6	the	the	DET
dti-1332	215	7	charged	charge	VERB
dti-1332	215	8	nanoparticles	nanoparticle	NOUN
dti-1332	215	9	and	and	CCONJ
dti-1332	215	10	it	it	PRON
dti-1332	215	11	tends	tend	VERB
dti-1332	215	12	to	to	PART
dti-1332	215	13	increase	increase	VERB
dti-1332	215	14	with	with	ADP
dti-1332	215	15	increase	increase	NOUN
dti-1332	215	16	in	in	ADP
dti-1332	215	17	the	the	DET
dti-1332	215	18	molecular	molecular	ADJ
dti-1332	215	19	weight	weight	NOUN
dti-1332	215	20	of	of	ADP
dti-1332	215	21	polymers	polymer	NOUN
dti-1332	215	22	having	have	VERB
dti-1332	215	23	similar	similar	ADJ
dti-1332	215	24	chemical	chemical	NOUN
dti-1332	215	25	structure	structure	NOUN
dti-1332	215	26	(	(	PUNCT
dti-1332	215	27	fischer	fischer	PROPN
dti-1332	215	28	et	et	PROPN
dti-1332	215	29	al	al	PROPN
dti-1332	215	30	.	.	PROPN
dti-1332	215	31	2003	2003	NUM
dti-1332	215	32	)	)	PUNCT
dti-1332	215	33	.	.	PUNCT
dti-1332	216	1	hence	hence	ADV
dti-1332	216	2	,	,	PUNCT
dti-1332	216	3	the	the	DET
dti-1332	216	4	surface	surface	NOUN
dti-1332	216	5	chemistry	chemistry	NOUN
dti-1332	216	6	affects	affect	VERB
dti-1332	216	7	the	the	DET
dti-1332	216	8	cytotoxicity	cytotoxicity	NOUN
dti-1332	216	9	,	,	PUNCT
dti-1332	216	10	infl	infl	PROPN
dti-1332	216	11	ammogenicity	ammogenicity	NOUN
dti-1332	216	12	and	and	CCONJ
dti-1332	216	13	fi	fi	NOUN
dti-1332	216	14	brogenicity	brogenicity	NOUN
dti-1332	216	15	.	.	PUNCT
dti-1332	217	1	self	self	NOUN
dti-1332	217	2	-	-	PUNCT
dti-1332	217	3	assembled	assemble	VERB
dti-1332	217	4	nanoparticles	nanoparticle	NOUN
dti-1332	217	5	(	(	PUNCT
dti-1332	217	6	chemical	chemical	NOUN
dti-1332	217	7	monomers	monomer	NOUN
dti-1332	217	8	that	that	PRON
dti-1332	217	9	naturally	naturally	ADV
dti-1332	217	10	polymerize	polymerize	VERB
dti-1332	217	11	,	,	PUNCT
dti-1332	217	12	creating	create	VERB
dti-1332	217	13	a	a	DET
dti-1332	217	14	polymer	polymer	NOUN
dti-1332	217	15	mesh	mesh	NOUN
dti-1332	217	16	)	)	PUNCT
dti-1332	217	17	have	have	VERB
dti-1332	217	18	an	an	DET
dti-1332	217	19	advantage	advantage	NOUN
dti-1332	217	20	as	as	ADP
dti-1332	217	21	altering	alter	VERB
dti-1332	217	22	the	the	DET
dti-1332	217	23	original	original	ADJ
dti-1332	217	24	monomers	monomer	NOUN
dti-1332	217	25	can	can	AUX
dti-1332	217	26	modify	modify	VERB
dti-1332	217	27	their	their	PRON
dti-1332	217	28	surface	surface	NOUN
dti-1332	217	29	properties	property	NOUN
dti-1332	217	30	.	.	PUNCT
dti-1332	218	1	complexes	complex	NOUN
dti-1332	218	2	whose	whose	DET
dti-1332	218	3	charges	charge	NOUN
dti-1332	218	4	are	be	AUX
dti-1332	218	5	close	close	ADJ
dti-1332	218	6	to	to	ADP
dti-1332	218	7	neutrality	neutrality	NOUN
dti-1332	218	8	show	show	VERB
dti-1332	218	9	high	high	ADJ
dti-1332	218	10	transfection	transfection	NOUN
dti-1332	218	11	efficiency	efficiency	NOUN
dti-1332	218	12	by	by	ADP
dti-1332	218	13	efficient	efficient	ADJ
dti-1332	218	14	receptor	receptor	NOUN
dti-1332	218	15	-	-	PUNCT
dti-1332	218	16	mediated	mediate	VERB
dti-1332	218	17	endocytosis	endocytosis	NOUN
dti-1332	218	18	but	but	CCONJ
dti-1332	218	19	the	the	DET
dti-1332	218	20	drawback	drawback	NOUN
dti-1332	218	21	is	be	AUX
dti-1332	218	22	that	that	SCONJ
dti-1332	218	23	,	,	PUNCT
dti-1332	218	24	neutral	neutral	ADJ
dti-1332	218	25	complexes	complex	NOUN
dti-1332	218	26	tend	tend	VERB
dti-1332	218	27	to	to	PART
dti-1332	218	28	aggregate	aggregate	VERB
dti-1332	218	29	among	among	ADP
dti-1332	218	30	themselves	themselves	PRON
dti-1332	218	31	due	due	ADP
dti-1332	218	32	to	to	ADP
dti-1332	218	33	predominant	predominant	ADJ
dti-1332	218	34	van	van	PROPN
dti-1332	218	35	der	der	PROPN
dti-1332	218	36	waal	waal	PROPN
dti-1332	218	37	forces	force	NOUN
dti-1332	218	38	and	and	CCONJ
dti-1332	218	39	further	further	ADJ
dti-1332	218	40	aggregation	aggregation	NOUN
dti-1332	218	41	and	and	CCONJ
dti-1332	218	42	adsorption	adsorption	NOUN
dti-1332	218	43	of	of	ADP
dti-1332	218	44	serum	serum	NOUN
dti-1332	218	45	proteins	protein	NOUN
dti-1332	218	46	resulting	result	VERB
dti-1332	218	47	into	into	ADP
dti-1332	218	48	rapid	rapid	ADJ
dti-1332	218	49	clearance	clearance	NOUN
dti-1332	218	50	of	of	ADP
dti-1332	218	51	the	the	DET
dti-1332	218	52	particle	particle	NOUN
dti-1332	218	53	.	.	PUNCT
dti-1332	219	1	to	to	PART
dti-1332	219	2	avoid	avoid	VERB
dti-1332	219	3	their	their	PRON
dti-1332	219	4	rapid	rapid	ADJ
dti-1332	219	5	clearance	clearance	NOUN
dti-1332	219	6	by	by	ADP
dti-1332	219	7	phagocyte	phagocyte	NOUN
dti-1332	219	8	capture	capture	NOUN
dti-1332	219	9	they	they	PRON
dti-1332	219	10	are	be	AUX
dti-1332	219	11	pegylated	pegylate	VERB
dti-1332	219	12	thus	thus	ADV
dti-1332	219	13	enhancing	enhance	VERB
dti-1332	219	14	permeation	permeation	NOUN
dti-1332	219	15	and	and	CCONJ
dti-1332	219	16	retention	retention	NOUN
dti-1332	219	17	effect	effect	NOUN
dti-1332	219	18	(	(	PUNCT
dti-1332	219	19	epr	epr	PROPN
dti-1332	219	20	)	)	PUNCT
dti-1332	219	21	with	with	ADP
dti-1332	219	22	low	low	ADJ
dti-1332	219	23	toxicity	toxicity	NOUN
dti-1332	219	24	and	and	CCONJ
dti-1332	219	25	they	they	PRON
dti-1332	219	26	also	also	ADV
dti-1332	219	27	suppress	suppress	VERB
dti-1332	219	28	any	any	DET
dti-1332	219	29	eliciting	eliciting	ADJ
dti-1332	219	30	immunological	immunological	ADJ
dti-1332	219	31	response	response	NOUN
dti-1332	219	32	.	.	PUNCT
dti-1332	220	1	pegylation	pegylation	NOUN
dti-1332	220	2	not	not	PART
dti-1332	220	3	only	only	ADV
dti-1332	220	4	enhances	enhance	VERB
dti-1332	220	5	the	the	DET
dti-1332	220	6	epr	epr	ADJ
dti-1332	220	7	effect	effect	NOUN
dti-1332	220	8	but	but	CCONJ
dti-1332	220	9	also	also	ADV
dti-1332	220	10	helps	help	VERB
dti-1332	220	11	to	to	PART
dti-1332	220	12	escape	escape	VERB
dti-1332	220	13	from	from	ADP
dti-1332	220	14	reticulo	reticulo	NOUN
dti-1332	220	15	-	-	PUNCT
dti-1332	220	16	endothelial	endothelial	NOUN
dti-1332	220	17	system	system	NOUN
dti-1332	220	18	(	(	PUNCT
dti-1332	220	19	res	re	NOUN
dti-1332	220	20	)	)	PUNCT
dti-1332	220	21	,	,	PUNCT
dti-1332	220	22	which	which	PRON
dti-1332	220	23	consists	consist	VERB
dti-1332	220	24	of	of	ADP
dti-1332	220	25	various	various	ADJ
dti-1332	220	26	degrading	degrade	VERB
dti-1332	220	27	enzymes	enzyme	NOUN
dti-1332	220	28	like	like	ADP
dti-1332	220	29	nuclease	nuclease	NOUN
dti-1332	220	30	,	,	PUNCT
dti-1332	220	31	proteases	protease	NOUN
dti-1332	220	32	and	and	CCONJ
dti-1332	220	33	lipases	lipase	NOUN
dti-1332	220	34	.	.	PUNCT
dti-1332	221	1	nevertheless	nevertheless	ADV
dti-1332	221	2	pegylation	pegylation	NOUN
dti-1332	221	3	stabilizes	stabilize	VERB
dti-1332	221	4	the	the	DET
dti-1332	221	5	particle	particle	NOUN
dti-1332	221	6	sterically	sterically	ADV
dti-1332	221	7	but	but	CCONJ
dti-1332	221	8	also	also	ADV
dti-1332	221	9	stabilizes	stabilize	VERB
dti-1332	221	10	it	it	PRON
dti-1332	221	11	in	in	ADP
dti-1332	221	12	salt	salt	NOUN
dti-1332	221	13	and	and	CCONJ
dti-1332	221	14	serum	serum	NOUN
dti-1332	221	15	solutions	solution	NOUN
dti-1332	221	16	(	(	PUNCT
dti-1332	221	17	ahn	ahn	PROPN
dti-1332	221	18	et	et	PROPN
dti-1332	221	19	al	al	PROPN
dti-1332	221	20	.	.	PROPN
dti-1332	221	21	2002	2002	NUM
dti-1332	221	22	;	;	PUNCT
dti-1332	221	23	oupicky	oupicky	PROPN
dti-1332	221	24	et	et	PROPN
dti-1332	221	25	al	al	PROPN
dti-1332	221	26	.	.	PROPN
dti-1332	221	27	2002	2002	NUM
dti-1332	221	28	;	;	PUNCT
dti-1332	221	29	park	park	NOUN
dti-1332	221	30	et	et	PROPN
dti-1332	221	31	al	al	PROPN
dti-1332	221	32	.	.	PROPN
dti-1332	221	33	2002	2002	NUM
dti-1332	221	34	)	)	PUNCT
dti-1332	221	35	.	.	PUNCT
dti-1332	222	1	when	when	SCONJ
dti-1332	222	2	peg	peg	NOUN
dti-1332	222	3	is	be	AUX
dti-1332	222	4	conjugated	conjugate	VERB
dti-1332	222	5	to	to	ADP
dti-1332	222	6	the	the	DET
dti-1332	222	7	particle	particle	NOUN
dti-1332	222	8	it	it	PRON
dti-1332	222	9	modifi	modifi	NOUN
dti-1332	222	10	es	es	ADP
dti-1332	222	11	the	the	DET
dti-1332	222	12	conformation	conformation	NOUN
dti-1332	222	13	and	and	CCONJ
dti-1332	222	14	the	the	DET
dti-1332	222	15	electrostatic	electrostatic	ADJ
dti-1332	222	16	binding	bind	VERB
dti-1332	222	17	properties	property	NOUN
dti-1332	222	18	thereby	thereby	ADV
dti-1332	222	19	,	,	PUNCT
dti-1332	222	20	reducing	reduce	VERB
dti-1332	222	21	the	the	DET
dti-1332	222	22	surface	surface	NOUN
dti-1332	222	23	potential	potential	NOUN
dti-1332	222	24	of	of	ADP
dti-1332	222	25	the	the	DET
dti-1332	222	26	nanoplexes	nanoplexe	NOUN
dti-1332	222	27	with	with	ADP
dti-1332	222	28	sirnas	sirna	NOUN
dti-1332	222	29	figure	figure	NOUN
dti-1332	222	30	4	4	NUM
dti-1332	222	31	.	.	PUNCT
dti-1332	222	32	nanoparticle	nanoparticle	NOUN
dti-1332	222	33	-	-	PUNCT
dti-1332	222	34	mediated	mediate	VERB
dti-1332	222	35	drug	drug	NOUN
dti-1332	222	36	/	/	SYM
dti-1332	222	37	gene	gene	NOUN
dti-1332	222	38	delivery	delivery	NOUN
dti-1332	222	39	:	:	PUNCT
dti-1332	222	40	overcoming	overcome	VERB
dti-1332	222	41	the	the	DET
dti-1332	222	42	barriers	barrier	NOUN
dti-1332	222	43	.	.	PUNCT
dti-1332	223	1	112	112	NUM
dti-1332	223	2	prakash	prakash	PROPN
dti-1332	223	3	and	and	CCONJ
dti-1332	223	4	malhotra	malhotra	PROPN
dti-1332	223	5	drug	drug	PROPN
dti-1332	223	6	target	target	NOUN
dti-1332	223	7	insights	insight	NOUN
dti-1332	223	8	2008:3	2008:3	NUM
dti-1332	223	9	from	from	ADP
dti-1332	223	10	35	35	NUM
dti-1332	223	11	±	±	NUM
dti-1332	223	12	4	4	NUM
dti-1332	223	13	mv	mv	NOUN
dti-1332	223	14	to	to	ADP
dti-1332	223	15	6	6	NUM
dti-1332	223	16	±	±	NUM
dti-1332	223	17	1	1	NUM
dti-1332	223	18	mv	mv	PROPN
dti-1332	223	19	(	(	PUNCT
dti-1332	223	20	schiffelers	schiffeler	NOUN
dti-1332	223	21	et	et	PROPN
dti-1332	223	22	al	al	PROPN
dti-1332	223	23	.	.	PROPN
dti-1332	223	24	2004	2004	NUM
dti-1332	223	25	)	)	PUNCT
dti-1332	223	26	.	.	PUNCT
dti-1332	224	1	this	this	DET
dti-1332	224	2	modifi	modifi	NOUN
dti-1332	224	3	cation	cation	NOUN
dti-1332	224	4	enhances	enhance	VERB
dti-1332	224	5	the	the	DET
dti-1332	224	6	biocompatibility	biocompatibility	NOUN
dti-1332	224	7	and	and	CCONJ
dti-1332	224	8	stability	stability	NOUN
dti-1332	224	9	of	of	ADP
dti-1332	224	10	the	the	DET
dti-1332	224	11	particle	particle	NOUN
dti-1332	224	12	by	by	ADP
dti-1332	224	13	decreasing	decrease	VERB
dti-1332	224	14	the	the	DET
dti-1332	224	15	electrostatic	electrostatic	ADJ
dti-1332	224	16	repulsion	repulsion	NOUN
dti-1332	224	17	between	between	ADP
dti-1332	224	18	surface	surface	NOUN
dti-1332	224	19	charges	charge	NOUN
dti-1332	224	20	(	(	PUNCT
dti-1332	224	21	mcneil	mcneil	PROPN
dti-1332	224	22	,	,	PUNCT
dti-1332	224	23	2005	2005	NUM
dti-1332	224	24	)	)	PUNCT
dti-1332	224	25	.	.	PUNCT
dti-1332	225	1	the	the	DET
dti-1332	225	2	overall	overall	ADJ
dti-1332	225	3	transfection	transfection	NOUN
dti-1332	225	4	effi	effi	PROPN
dti-1332	225	5	ciency	ciency	NOUN
dti-1332	225	6	of	of	ADP
dti-1332	225	7	pegylated	pegylated	ADJ
dti-1332	225	8	nanoplexes	nanoplexe	NOUN
dti-1332	225	9	is	be	AUX
dti-1332	225	10	based	base	VERB
dti-1332	225	11	on	on	ADP
dti-1332	225	12	the	the	DET
dti-1332	225	13	cell	cell	NOUN
dti-1332	225	14	types	type	NOUN
dti-1332	225	15	and	and	CCONJ
dti-1332	225	16	density	density	NOUN
dti-1332	225	17	,	,	PUNCT
dti-1332	225	18	chemical	chemical	ADJ
dti-1332	225	19	nature	nature	NOUN
dti-1332	225	20	of	of	ADP
dti-1332	225	21	nanoplexes	nanoplexe	NOUN
dti-1332	225	22	,	,	PUNCT
dti-1332	225	23	length	length	NOUN
dti-1332	225	24	of	of	ADP
dti-1332	225	25	exposure	exposure	NOUN
dti-1332	225	26	of	of	ADP
dti-1332	225	27	cells	cell	NOUN
dti-1332	225	28	to	to	ADP
dti-1332	225	29	polyplex	polyplex	NOUN
dti-1332	225	30	-	-	PUNCT
dti-1332	225	31	sirna	sirna	PROPN
dti-1332	225	32	complexes	complex	NOUN
dti-1332	225	33	and	and	CCONJ
dti-1332	225	34	the	the	DET
dti-1332	225	35	size	size	NOUN
dti-1332	225	36	and	and	CCONJ
dti-1332	225	37	concentration	concentration	NOUN
dti-1332	225	38	of	of	ADP
dti-1332	225	39	sirna	sirna	PROPN
dti-1332	225	40	.	.	PUNCT
dti-1332	226	1	the	the	DET
dti-1332	226	2	sirnas	sirna	NOUN
dti-1332	226	3	incorporated	incorporate	VERB
dti-1332	226	4	into	into	ADP
dti-1332	226	5	pegylated	pegylated	ADJ
dti-1332	226	6	nanoparticles	nanoparticle	NOUN
dti-1332	226	7	are	be	AUX
dti-1332	226	8	ligated	ligate	VERB
dti-1332	226	9	to	to	ADP
dti-1332	226	10	monoclonal	monoclonal	NOUN
dti-1332	226	11	antibodies	antibody	NOUN
dti-1332	226	12	or	or	CCONJ
dti-1332	226	13	cell	cell	NOUN
dti-1332	226	14	surface	surface	NOUN
dti-1332	226	15	receptor	receptor	NOUN
dti-1332	226	16	ligands	ligand	NOUN
dti-1332	226	17	,	,	PUNCT
dti-1332	226	18	which	which	PRON
dti-1332	226	19	will	will	AUX
dti-1332	226	20	target	target	VERB
dti-1332	226	21	the	the	DET
dti-1332	226	22	molecules	molecule	NOUN
dti-1332	226	23	present	present	ADJ
dti-1332	226	24	on	on	ADP
dti-1332	226	25	the	the	DET
dti-1332	226	26	surface	surface	NOUN
dti-1332	226	27	of	of	ADP
dti-1332	226	28	the	the	DET
dti-1332	226	29	cells	cell	NOUN
dti-1332	226	30	.	.	PUNCT
dti-1332	227	1	mostly	mostly	ADV
dti-1332	227	2	used	use	VERB
dti-1332	227	3	targeting	target	VERB
dti-1332	227	4	molecules	molecule	NOUN
dti-1332	227	5	are	be	AUX
dti-1332	227	6	folate	folate	NOUN
dti-1332	227	7	,	,	PUNCT
dti-1332	227	8	luteinizing	luteinize	VERB
dti-1332	227	9	hormone	hormone	NOUN
dti-1332	227	10	-	-	PUNCT
dti-1332	227	11	releasing	release	VERB
dti-1332	227	12	hormone	hormone	NOUN
dti-1332	227	13	(	(	PUNCT
dti-1332	227	14	lh	lh	PROPN
dti-1332	227	15	-	-	PUNCT
dti-1332	227	16	rh	rh	PROPN
dti-1332	227	17	)	)	PUNCT
dti-1332	227	18	,	,	PUNCT
dti-1332	227	19	thiamine	thiamine	NOUN
dti-1332	227	20	,	,	PUNCT
dti-1332	227	21	receptor	receptor	NOUN
dti-1332	227	22	specifi	specifi	PROPN
dti-1332	227	23	c	c	PROPN
dti-1332	227	24	peptides	peptide	NOUN
dti-1332	227	25	,	,	PUNCT
dti-1332	227	26	aptamers	aptamer	NOUN
dti-1332	227	27	and	and	CCONJ
dti-1332	227	28	the	the	DET
dti-1332	227	29	monoclonal	monoclonal	NOUN
dti-1332	227	30	antibodies	antibody	NOUN
dti-1332	227	31	used	use	VERB
dti-1332	227	32	against	against	ADP
dti-1332	227	33	cell	cell	NOUN
dti-1332	227	34	surface	surface	NOUN
dti-1332	227	35	receptors	receptor	NOUN
dti-1332	227	36	such	such	ADJ
dti-1332	227	37	as	as	ADP
dti-1332	227	38	integrins	integrin	NOUN
dti-1332	227	39	,	,	PUNCT
dti-1332	227	40	transferrin	transferrin	NOUN
dti-1332	227	41	(	(	PUNCT
dti-1332	227	42	tfr	tfr	PROPN
dti-1332	227	43	)	)	PUNCT
dti-1332	227	44	,	,	PUNCT
dti-1332	227	45	egf	egf	PROPN
dti-1332	227	46	,	,	PUNCT
dti-1332	227	47	insulin	insulin	NOUN
dti-1332	227	48	receptors	receptor	NOUN
dti-1332	227	49	etc	etc	X
dti-1332	227	50	.	.	X
dti-1332	228	1	(	(	PUNCT
dti-1332	228	2	mcneil	mcneil	PROPN
dti-1332	228	3	,	,	PUNCT
dti-1332	228	4	2005	2005	NUM
dti-1332	228	5	)	)	PUNCT
dti-1332	228	6	.	.	PUNCT
dti-1332	229	1	presence	presence	NOUN
dti-1332	229	2	of	of	ADP
dti-1332	229	3	monoclonal	monoclonal	NOUN
dti-1332	229	4	antibodies	antibody	NOUN
dti-1332	229	5	targeting	target	VERB
dti-1332	229	6	to	to	ADP
dti-1332	229	7	such	such	ADJ
dti-1332	229	8	surface	surface	NOUN
dti-1332	229	9	receptors	receptor	NOUN
dti-1332	229	10	facilitates	facilitate	VERB
dti-1332	229	11	selective	selective	ADJ
dti-1332	229	12	cell	cell	NOUN
dti-1332	229	13	binding	bind	VERB
dti-1332	229	14	(	(	PUNCT
dti-1332	229	15	schiffelers	schiffeler	NOUN
dti-1332	229	16	et	et	PROPN
dti-1332	229	17	al	al	PROPN
dti-1332	229	18	.	.	PROPN
dti-1332	229	19	2004	2004	NUM
dti-1332	229	20	)	)	PUNCT
dti-1332	229	21	and	and	CCONJ
dti-1332	229	22	ensures	ensure	VERB
dti-1332	229	23	an	an	DET
dti-1332	229	24	easy	easy	ADJ
dti-1332	229	25	entry	entry	NOUN
dti-1332	229	26	of	of	ADP
dti-1332	229	27	nanoparticles	nanoparticle	NOUN
dti-1332	229	28	into	into	ADP
dti-1332	229	29	the	the	DET
dti-1332	229	30	targeted	target	VERB
dti-1332	229	31	cell	cell	NOUN
dti-1332	229	32	by	by	ADP
dti-1332	229	33	a	a	DET
dti-1332	229	34	mechanism	mechanism	NOUN
dti-1332	229	35	of	of	ADP
dti-1332	229	36	receptor	receptor	NOUN
dti-1332	229	37	-	-	PUNCT
dti-1332	229	38	mediated	mediate	VERB
dti-1332	229	39	endocytosis	endocytosis	NOUN
dti-1332	229	40	.	.	PUNCT
dti-1332	230	1	these	these	DET
dti-1332	230	2	nanoparticles	nanoparticle	NOUN
dti-1332	230	3	being	be	AUX
dti-1332	230	4	biodegradable	biodegradable	ADJ
dti-1332	230	5	in	in	ADP
dti-1332	230	6	nature	nature	NOUN
dti-1332	230	7	release	release	VERB
dti-1332	230	8	the	the	DET
dti-1332	230	9	incorporated	incorporated	ADJ
dti-1332	230	10	sirna	sirna	PROPN
dti-1332	230	11	to	to	ADP
dti-1332	230	12	the	the	DET
dti-1332	230	13	target	target	NOUN
dti-1332	230	14	site	site	NOUN
dti-1332	230	15	and	and	CCONJ
dti-1332	230	16	ensure	ensure	VERB
dti-1332	230	17	site	site	NOUN
dti-1332	230	18	-	-	PUNCT
dti-1332	230	19	specifi	specifi	PROPN
dti-1332	230	20	c	c	PROPN
dti-1332	230	21	gene	gene	NOUN
dti-1332	230	22	silencing	silence	VERB
dti-1332	230	23	.	.	PUNCT
dti-1332	231	1	the	the	DET
dti-1332	231	2	mechanism	mechanism	NOUN
dti-1332	231	3	of	of	ADP
dti-1332	231	4	transfection	transfection	NOUN
dti-1332	231	5	of	of	ADP
dti-1332	231	6	sirna	sirna	PROPN
dti-1332	231	7	through	through	ADP
dti-1332	231	8	cationic	cationic	ADJ
dti-1332	231	9	nanocarriers	nanocarrier	NOUN
dti-1332	231	10	in	in	ADP
dti-1332	231	11	the	the	DET
dti-1332	231	12	cell	cell	NOUN
dti-1332	231	13	via	via	ADP
dti-1332	231	14	receptor	receptor	NOUN
dti-1332	231	15	-	-	PUNCT
dti-1332	231	16	mediated	mediate	VERB
dti-1332	231	17	endocytosis	endocytosis	NOUN
dti-1332	231	18	is	be	AUX
dti-1332	231	19	described	describe	VERB
dti-1332	231	20	in	in	ADP
dti-1332	231	21	figure	figure	NOUN
dti-1332	231	22	5	5	NUM
dti-1332	231	23	.	.	PUNCT
dti-1332	232	1	studies	study	NOUN
dti-1332	232	2	reveal	reveal	VERB
dti-1332	232	3	that	that	SCONJ
dti-1332	232	4	the	the	DET
dti-1332	232	5	reason	reason	NOUN
dti-1332	232	6	for	for	ADP
dti-1332	232	7	reduced	reduced	ADJ
dti-1332	232	8	intracellular	intracellular	ADJ
dti-1332	232	9	uptake	uptake	NOUN
dti-1332	232	10	of	of	ADP
dti-1332	232	11	naked	naked	ADJ
dti-1332	232	12	sirnas	sirna	NOUN
dti-1332	232	13	in	in	ADP
dti-1332	232	14	aqueous	aqueous	ADJ
dti-1332	232	15	solution	solution	NOUN
dti-1332	232	16	is	be	AUX
dti-1332	232	17	due	due	ADJ
dti-1332	232	18	to	to	ADP
dti-1332	232	19	their	their	PRON
dti-1332	232	20	strong	strong	ADJ
dti-1332	232	21	anionic	anionic	ADJ
dti-1332	232	22	character	character	NOUN
dti-1332	232	23	while	while	SCONJ
dti-1332	232	24	in	in	ADP
dti-1332	232	25	the	the	DET
dti-1332	232	26	case	case	NOUN
dti-1332	232	27	of	of	ADP
dti-1332	232	28	pegylated	pegylated	ADJ
dti-1332	232	29	nanoplexes	nanoplexe	NOUN
dti-1332	232	30	the	the	DET
dti-1332	232	31	steric	steric	ADJ
dti-1332	232	32	layer	layer	NOUN
dti-1332	232	33	reduces	reduce	VERB
dti-1332	232	34	the	the	DET
dti-1332	232	35	cellular	cellular	ADJ
dti-1332	232	36	uptake	uptake	NOUN
dti-1332	232	37	but	but	CCONJ
dti-1332	232	38	those	those	PRON
dti-1332	232	39	which	which	PRON
dti-1332	232	40	are	be	AUX
dti-1332	232	41	pegylated	pegylate	VERB
dti-1332	232	42	and	and	CCONJ
dti-1332	232	43	have	have	VERB
dti-1332	232	44	cell	cell	NOUN
dti-1332	232	45	surface	surface	NOUN
dti-1332	232	46	receptor	receptor	NOUN
dti-1332	232	47	ligands	ligand	NOUN
dti-1332	232	48	are	be	AUX
dti-1332	232	49	easily	easily	ADV
dti-1332	232	50	taken	take	VERB
dti-1332	232	51	up	up	ADP
dti-1332	232	52	by	by	ADP
dti-1332	232	53	the	the	DET
dti-1332	232	54	cell	cell	NOUN
dti-1332	232	55	system	system	NOUN
dti-1332	232	56	and	and	CCONJ
dti-1332	232	57	are	be	AUX
dti-1332	232	58	successful	successful	ADJ
dti-1332	232	59	in	in	ADP
dti-1332	232	60	inhibiting	inhibit	VERB
dti-1332	232	61	the	the	DET
dti-1332	232	62	gene	gene	NOUN
dti-1332	232	63	expression	expression	NOUN
dti-1332	232	64	by	by	ADP
dti-1332	232	65	~90	~90	NUM
dti-1332	232	66	%	%	NOUN
dti-1332	232	67	.	.	PUNCT
dti-1332	233	1	targeting	target	VERB
dti-1332	233	2	cns	cns	NOUN
dti-1332	233	3	for	for	ADP
dti-1332	233	4	therapeutic	therapeutic	ADJ
dti-1332	233	5	treatment	treatment	NOUN
dti-1332	233	6	has	have	AUX
dti-1332	233	7	mostly	mostly	ADV
dti-1332	233	8	been	be	AUX
dti-1332	233	9	ineffective	ineffective	ADJ
dti-1332	233	10	due	due	ADP
dti-1332	233	11	to	to	ADP
dti-1332	233	12	the	the	DET
dti-1332	233	13	tight	tight	ADJ
dti-1332	233	14	endothelial	endothelial	NOUN
dti-1332	233	15	lining	lining	NOUN
dti-1332	233	16	made	make	VERB
dti-1332	233	17	of	of	ADP
dti-1332	233	18	capillaries	capillary	NOUN
dti-1332	233	19	forming	form	VERB
dti-1332	233	20	bbb	bbb	PROPN
dti-1332	233	21	.	.	PUNCT
dti-1332	234	1	as	as	SCONJ
dti-1332	234	2	discussed	discuss	VERB
dti-1332	234	3	before	before	ADV
dti-1332	234	4	that	that	PRON
dti-1332	234	5	only	only	ADJ
dti-1332	234	6	non	non	ADJ
dti-1332	234	7	-	-	ADJ
dti-1332	234	8	ionized	ionized	ADJ
dti-1332	234	9	,	,	PUNCT
dti-1332	234	10	hydrophilic	hydrophilic	ADJ
dti-1332	234	11	and	and	CCONJ
dti-1332	234	12	low	low	ADJ
dti-1332	234	13	molecular	molecular	ADJ
dti-1332	234	14	weight	weight	NOUN
dti-1332	234	15	can	can	AUX
dti-1332	234	16	diffuse	diffuse	VERB
dti-1332	234	17	across	across	ADP
dti-1332	234	18	the	the	DET
dti-1332	234	19	bbb	bbb	PROPN
dti-1332	234	20	.	.	PUNCT
dti-1332	235	1	development	development	NOUN
dti-1332	235	2	of	of	ADP
dti-1332	235	3	synthetically	synthetically	ADV
dti-1332	235	4	designed	design	VERB
dti-1332	235	5	figure	figure	NOUN
dti-1332	235	6	5	5	NUM
dti-1332	235	7	.	.	PUNCT
dti-1332	235	8	mode	mode	NOUN
dti-1332	235	9	of	of	ADP
dti-1332	235	10	action	action	NOUN
dti-1332	235	11	of	of	ADP
dti-1332	235	12	therapeutic	therapeutic	ADJ
dti-1332	235	13	transfection	transfection	NOUN
dti-1332	235	14	of	of	ADP
dti-1332	235	15	sirna	sirna	PROPN
dti-1332	235	16	through	through	ADP
dti-1332	235	17	cationic	cationic	ADJ
dti-1332	235	18	nanocarriers	nanocarrier	NOUN
dti-1332	235	19	in	in	ADP
dti-1332	235	20	the	the	DET
dti-1332	235	21	cell	cell	NOUN
dti-1332	235	22	via	via	ADP
dti-1332	235	23	receptor	receptor	NOUN
dti-1332	235	24	-	-	PUNCT
dti-1332	235	25	mediated	mediate	VERB
dti-1332	235	26	endocytosis	endocytosis	NOUN
dti-1332	235	27	.	.	PUNCT
dti-1332	236	1	113	113	NUM
dti-1332	236	2	recent	recent	ADJ
dti-1332	236	3	advancements	advancement	NOUN
dti-1332	236	4	in	in	ADP
dti-1332	236	5	targeted	target	VERB
dti-1332	236	6	delivery	delivery	NOUN
dti-1332	236	7	of	of	ADP
dti-1332	236	8	therapeutic	therapeutic	ADJ
dti-1332	236	9	molecules	molecule	NOUN
dti-1332	236	10	drug	drug	NOUN
dti-1332	236	11	target	target	NOUN
dti-1332	236	12	insights	insight	VERB
dti-1332	236	13	2008:3	2008:3	NUM
dti-1332	236	14	biodegradable	biodegradable	ADJ
dti-1332	236	15	nanoparticles	nanoparticle	NOUN
dti-1332	236	16	has	have	AUX
dti-1332	236	17	shown	show	VERB
dti-1332	236	18	a	a	DET
dti-1332	236	19	possibility	possibility	NOUN
dti-1332	236	20	to	to	PART
dti-1332	236	21	overcome	overcome	VERB
dti-1332	236	22	this	this	DET
dti-1332	236	23	barrier	barrier	NOUN
dti-1332	236	24	.	.	PUNCT
dti-1332	237	1	poly	poly	NOUN
dti-1332	237	2	(	(	PUNCT
dti-1332	237	3	butyl	butyl	NOUN
dti-1332	237	4	cyanoacrylate	cyanoacrylate	NOUN
dti-1332	237	5	)	)	PUNCT
dti-1332	237	6	(	(	PUNCT
dti-1332	237	7	pbca	pbca	NOUN
dti-1332	237	8	)	)	PUNCT
dti-1332	237	9	nanoparticles	nanoparticle	NOUN
dti-1332	237	10	has	have	AUX
dti-1332	237	11	most	most	ADV
dti-1332	237	12	widely	widely	ADV
dti-1332	237	13	been	be	AUX
dti-1332	237	14	used	use	VERB
dti-1332	237	15	for	for	ADP
dti-1332	237	16	brain	brain	NOUN
dti-1332	237	17	delivery	delivery	NOUN
dti-1332	237	18	(	(	PUNCT
dti-1332	237	19	kreuter	kreuter	NOUN
dti-1332	237	20	et	et	PROPN
dti-1332	237	21	al	al	PROPN
dti-1332	237	22	.	.	PROPN
dti-1332	237	23	2001	2001	NUM
dti-1332	237	24	)	)	PUNCT
dti-1332	237	25	.	.	PUNCT
dti-1332	238	1	to	to	PART
dti-1332	238	2	make	make	VERB
dti-1332	238	3	pbca	pbca	ADJ
dti-1332	238	4	nanoparticles	nanoparticle	NOUN
dti-1332	238	5	more	more	ADV
dti-1332	238	6	biocompatible	biocompatible	ADJ
dti-1332	238	7	and	and	CCONJ
dti-1332	238	8	to	to	PART
dti-1332	238	9	enhance	enhance	VERB
dti-1332	238	10	the	the	DET
dti-1332	238	11	penetration	penetration	NOUN
dti-1332	238	12	they	they	PRON
dti-1332	238	13	were	be	AUX
dti-1332	238	14	overcoated	overcoate	VERB
dti-1332	238	15	with	with	ADP
dti-1332	238	16	polysorbate80	polysorbate80	NOUN
dti-1332	238	17	both	both	CCONJ
dti-1332	238	18	in	in	ADP
dti-1332	238	19	vitro	vitro	X
dti-1332	238	20	and	and	CCONJ
dti-1332	238	21	in	in	ADP
dti-1332	238	22	vivo	vivo	NOUN
dti-1332	238	23	.	.	PUNCT
dti-1332	239	1	using	use	VERB
dti-1332	239	2	this	this	DET
dti-1332	239	3	mechanism	mechanism	NOUN
dti-1332	239	4	,	,	PUNCT
dti-1332	239	5	researchers	researcher	NOUN
dti-1332	239	6	have	have	AUX
dti-1332	239	7	successfully	successfully	ADV
dti-1332	239	8	delivered	deliver	VERB
dti-1332	239	9	several	several	ADJ
dti-1332	239	10	drugs	drug	NOUN
dti-1332	239	11	like	like	ADP
dti-1332	239	12	hexapeptide	hexapeptide	NOUN
dti-1332	239	13	dalargin	dalargin	NOUN
dti-1332	239	14	(	(	PUNCT
dti-1332	239	15	alyautdin	alyautdin	NOUN
dti-1332	239	16	et	et	PROPN
dti-1332	239	17	al	al	PROPN
dti-1332	239	18	.	.	PROPN
dti-1332	239	19	1995	1995	NUM
dti-1332	239	20	)	)	PUNCT
dti-1332	239	21	,	,	PUNCT
dti-1332	239	22	doxorubicin	doxorubicin	PROPN
dti-1332	239	23	(	(	PUNCT
dti-1332	239	24	anticancer	anticancer	NOUN
dti-1332	239	25	drug	drug	NOUN
dti-1332	239	26	)	)	PUNCT
dti-1332	239	27	to	to	ADP
dti-1332	239	28	the	the	DET
dti-1332	239	29	brain	brain	NOUN
dti-1332	239	30	(	(	PUNCT
dti-1332	239	31	gulyaev	gulyaev	NOUN
dti-1332	239	32	et	et	PROPN
dti-1332	239	33	al	al	PROPN
dti-1332	239	34	.	.	PROPN
dti-1332	239	35	1999	1999	NUM
dti-1332	239	36	)	)	PUNCT
dti-1332	239	37	.	.	PUNCT
dti-1332	240	1	the	the	DET
dti-1332	240	2	success	success	NOUN
dti-1332	240	3	of	of	ADP
dti-1332	240	4	using	use	VERB
dti-1332	240	5	polysorbate80	polysorbate80	NOUN
dti-1332	240	6	overcoated	overcoate	VERB
dti-1332	240	7	nanoparticles	nanoparticle	NOUN
dti-1332	240	8	was	be	AUX
dti-1332	240	9	because	because	SCONJ
dti-1332	240	10	they	they	PRON
dti-1332	240	11	act	act	VERB
dti-1332	240	12	as	as	ADP
dti-1332	240	13	an	an	DET
dti-1332	240	14	anchor	anchor	NOUN
dti-1332	240	15	for	for	ADP
dti-1332	240	16	apolipoprotein	apolipoprotein	ADJ
dti-1332	240	17	e	e	PROPN
dti-1332	240	18	,	,	PUNCT
dti-1332	240	19	which	which	PRON
dti-1332	240	20	is	be	AUX
dti-1332	240	21	involved	involve	VERB
dti-1332	240	22	in	in	ADP
dti-1332	240	23	uptake	uptake	NOUN
dti-1332	240	24	of	of	ADP
dti-1332	240	25	ldl	ldl	NOUN
dti-1332	240	26	by	by	ADP
dti-1332	240	27	the	the	DET
dti-1332	240	28	brain	brain	NOUN
dti-1332	240	29	.	.	PUNCT
dti-1332	241	1	upon	upon	SCONJ
dti-1332	241	2	systemic	systemic	ADJ
dti-1332	241	3	delivery	delivery	NOUN
dti-1332	241	4	of	of	ADP
dti-1332	241	5	nanoparticles	nanoparticle	NOUN
dti-1332	241	6	the	the	DET
dti-1332	241	7	uptake	uptake	NOUN
dti-1332	241	8	by	by	ADP
dti-1332	241	9	reticulo	reticulo	NOUN
dti-1332	241	10	-	-	PUNCT
dti-1332	241	11	endothelial	endothelial	NOUN
dti-1332	241	12	system	system	NOUN
dti-1332	241	13	(	(	PUNCT
dti-1332	241	14	res	re	NOUN
dti-1332	241	15	)	)	PUNCT
dti-1332	241	16	is	be	AUX
dti-1332	241	17	another	another	DET
dti-1332	241	18	barrier	barrier	NOUN
dti-1332	241	19	that	that	PRON
dti-1332	241	20	restricts	restrict	VERB
dti-1332	241	21	nanoparticles	nanoparticle	NOUN
dti-1332	241	22	to	to	PART
dti-1332	241	23	reach	reach	VERB
dti-1332	241	24	bbb	bbb	PROPN
dti-1332	241	25	,	,	PUNCT
dti-1332	241	26	overcoating	overcoate	VERB
dti-1332	241	27	with	with	ADP
dti-1332	241	28	surfactants	surfactant	NOUN
dti-1332	241	29	like	like	ADP
dti-1332	241	30	polysorbate80	polysorbate80	NOUN
dti-1332	241	31	and	and	CCONJ
dti-1332	241	32	polaxmine908	polaxmine908	PROPN
dti-1332	241	33	has	have	AUX
dti-1332	241	34	been	be	AUX
dti-1332	241	35	observed	observe	VERB
dti-1332	241	36	to	to	PART
dti-1332	241	37	increase	increase	VERB
dti-1332	241	38	the	the	DET
dti-1332	241	39	residence	residence	NOUN
dti-1332	241	40	time	time	NOUN
dti-1332	241	41	of	of	ADP
dti-1332	241	42	the	the	DET
dti-1332	241	43	particle	particle	NOUN
dti-1332	241	44	and	and	CCONJ
dti-1332	241	45	reduce	reduce	VERB
dti-1332	241	46	uptake	uptake	NOUN
dti-1332	241	47	by	by	ADP
dti-1332	241	48	res	re	NOUN
dti-1332	241	49	.	.	PUNCT
dti-1332	242	1	conclusion	conclusion	NOUN
dti-1332	242	2	autosomal	autosomal	ADJ
dti-1332	242	3	dominant	dominant	ADJ
dti-1332	242	4	cerebellar	cerebellar	ADJ
dti-1332	242	5	ataxia	ataxia	NOUN
dti-1332	242	6	is	be	AUX
dti-1332	242	7	a	a	DET
dti-1332	242	8	complicated	complicated	ADJ
dti-1332	242	9	genetic	genetic	ADJ
dti-1332	242	10	disorder	disorder	NOUN
dti-1332	242	11	.	.	PUNCT
dti-1332	243	1	there	there	PRON
dti-1332	243	2	are	be	VERB
dti-1332	243	3	specifi	specifi	PROPN
dti-1332	243	4	c	c	PROPN
dti-1332	243	5	occupational	occupational	ADJ
dti-1332	243	6	and	and	CCONJ
dti-1332	243	7	physical	physical	ADJ
dti-1332	243	8	therapies	therapy	NOUN
dti-1332	243	9	available	available	ADJ
dti-1332	243	10	for	for	ADP
dti-1332	243	11	this	this	DET
dti-1332	243	12	disease	disease	NOUN
dti-1332	243	13	.	.	PUNCT
dti-1332	244	1	several	several	ADJ
dti-1332	244	2	drugs	drug	NOUN
dti-1332	244	3	/	/	SYM
dti-1332	244	4	therapies	therapy	NOUN
dti-1332	244	5	are	be	AUX
dti-1332	244	6	in	in	ADP
dti-1332	244	7	the	the	DET
dti-1332	244	8	clinical	clinical	ADJ
dti-1332	244	9	trial	trial	NOUN
dti-1332	244	10	phases	phase	NOUN
dti-1332	244	11	.	.	PUNCT
dti-1332	245	1	the	the	DET
dti-1332	245	2	use	use	NOUN
dti-1332	245	3	of	of	ADP
dti-1332	245	4	sirna	sirna	PROPN
dti-1332	245	5	has	have	AUX
dti-1332	245	6	shown	show	VERB
dti-1332	245	7	to	to	PART
dti-1332	245	8	be	be	AUX
dti-1332	245	9	the	the	DET
dti-1332	245	10	promising	promising	ADJ
dti-1332	245	11	approach	approach	NOUN
dti-1332	245	12	to	to	PART
dti-1332	245	13	silence	silence	VERB
dti-1332	245	14	the	the	DET
dti-1332	245	15	diseased	diseased	ADJ
dti-1332	245	16	gene	gene	NOUN
dti-1332	245	17	.	.	PUNCT
dti-1332	246	1	however	however	ADV
dti-1332	246	2	,	,	PUNCT
dti-1332	246	3	targeted	targeted	ADJ
dti-1332	246	4	delivery	delivery	NOUN
dti-1332	246	5	of	of	ADP
dti-1332	246	6	sirna’s/	sirna’s/	ADJ
dti-1332	246	7	therapeutic	therapeutic	ADJ
dti-1332	246	8	molecules	molecule	NOUN
dti-1332	246	9	at	at	ADP
dti-1332	246	10	the	the	DET
dti-1332	246	11	specifi	specifi	PROPN
dti-1332	246	12	c	c	PROPN
dti-1332	246	13	site	site	NOUN
dti-1332	246	14	matters	matter	NOUN
dti-1332	246	15	.	.	PUNCT
dti-1332	247	1	precision	precision	NOUN
dti-1332	247	2	,	,	PUNCT
dti-1332	247	3	specificity	specificity	NOUN
dti-1332	247	4	,	,	PUNCT
dti-1332	247	5	and	and	CCONJ
dti-1332	247	6	efficiency	efficiency	NOUN
dti-1332	247	7	is	be	AUX
dti-1332	247	8	an	an	DET
dti-1332	247	9	art	art	NOUN
dti-1332	247	10	to	to	PART
dti-1332	247	11	achieve	achieve	VERB
dti-1332	247	12	therapeutic	therapeutic	ADJ
dti-1332	247	13	benefi	benefi	NOUN
dti-1332	247	14	ts	ts	NOUN
dti-1332	247	15	.	.	PUNCT
dti-1332	248	1	however	however	ADV
dti-1332	248	2	,	,	PUNCT
dti-1332	248	3	research	research	NOUN
dti-1332	248	4	development	development	NOUN
dti-1332	248	5	and	and	CCONJ
dti-1332	248	6	progress	progress	NOUN
dti-1332	248	7	in	in	ADP
dti-1332	248	8	medical	medical	ADJ
dti-1332	248	9	sciences	science	NOUN
dti-1332	248	10	is	be	AUX
dti-1332	248	11	trying	try	VERB
dti-1332	248	12	to	to	PART
dti-1332	248	13	generate	generate	VERB
dti-1332	248	14	a	a	DET
dti-1332	248	15	new	new	ADJ
dti-1332	248	16	life	life	NOUN
dti-1332	248	17	by	by	ADP
dti-1332	248	18	combining	combine	VERB
dti-1332	248	19	different	different	ADJ
dti-1332	248	20	sections	section	NOUN
dti-1332	248	21	of	of	ADP
dti-1332	248	22	research	research	NOUN
dti-1332	248	23	together	together	ADV
dti-1332	248	24	.	.	PUNCT
dti-1332	249	1	research	research	NOUN
dti-1332	249	2	on	on	ADP
dti-1332	249	3	polymeric	polymeric	ADJ
dti-1332	249	4	based	base	VERB
dti-1332	249	5	biodegradable	biodegradable	ADJ
dti-1332	249	6	nanoparticles	nanoparticle	NOUN
dti-1332	249	7	to	to	PART
dti-1332	249	8	be	be	AUX
dti-1332	249	9	used	use	VERB
dti-1332	249	10	as	as	ADP
dti-1332	249	11	nanomedicne	nanomedicne	NOUN
dti-1332	249	12	is	be	AUX
dti-1332	249	13	still	still	ADV
dti-1332	249	14	in	in	ADP
dti-1332	249	15	its	its	PRON
dti-1332	249	16	infancy	infancy	NOUN
dti-1332	249	17	and	and	CCONJ
dti-1332	249	18	has	have	AUX
dti-1332	249	19	induced	induce	VERB
dti-1332	249	20	researchers	researcher	NOUN
dti-1332	249	21	to	to	PART
dti-1332	249	22	explore	explore	VERB
dti-1332	249	23	and	and	CCONJ
dti-1332	249	24	exploit	exploit	VERB
dti-1332	249	25	their	their	PRON
dti-1332	249	26	novel	novel	ADJ
dti-1332	249	27	ideas	idea	NOUN
dti-1332	249	28	.	.	PUNCT
dti-1332	250	1	several	several	ADJ
dti-1332	250	2	issues	issue	NOUN
dti-1332	250	3	arise	arise	VERB
dti-1332	250	4	when	when	SCONJ
dti-1332	250	5	considering	consider	VERB
dti-1332	250	6	the	the	DET
dti-1332	250	7	delivery	delivery	NOUN
dti-1332	250	8	aspect	aspect	NOUN
dti-1332	250	9	of	of	ADP
dti-1332	250	10	sirna	sirna	PROPN
dti-1332	250	11	.	.	PUNCT
dti-1332	251	1	a	a	DET
dti-1332	251	2	logical	logical	ADJ
dti-1332	251	3	action	action	NOUN
dti-1332	251	4	is	be	AUX
dti-1332	251	5	required	require	VERB
dti-1332	251	6	to	to	PART
dti-1332	251	7	make	make	VERB
dti-1332	251	8	sirna	sirna	PROPN
dti-1332	251	9	drugs	drug	NOUN
dti-1332	251	10	as	as	ADP
dti-1332	251	11	attractive	attractive	ADJ
dti-1332	251	12	therapeutic	therapeutic	ADJ
dti-1332	251	13	option	option	NOUN
dti-1332	251	14	in	in	ADP
dti-1332	251	15	various	various	ADJ
dti-1332	251	16	target	target	NOUN
dti-1332	251	17	sites	site	NOUN
dti-1332	251	18	such	such	ADJ
dti-1332	251	19	as	as	ADP
dti-1332	251	20	liver	liver	NOUN
dti-1332	251	21	cells	cell	NOUN
dti-1332	251	22	,	,	PUNCT
dti-1332	251	23	macrophages	macrophage	NOUN
dti-1332	251	24	and	and	CCONJ
dti-1332	251	25	neuronal	neuronal	ADJ
dti-1332	251	26	cells	cell	NOUN
dti-1332	251	27	that	that	PRON
dti-1332	251	28	are	be	AUX
dti-1332	251	29	slow	slow	ADJ
dti-1332	251	30	dividing	dividing	NOUN
dti-1332	251	31	as	as	ADP
dti-1332	251	32	an	an	DET
dti-1332	251	33	ideal	ideal	ADJ
dti-1332	251	34	place	place	NOUN
dti-1332	251	35	.	.	PUNCT
dti-1332	252	1	but	but	CCONJ
dti-1332	252	2	the	the	DET
dti-1332	252	3	problem	problem	NOUN
dti-1332	252	4	arises	arise	VERB
dti-1332	252	5	in	in	ADP
dti-1332	252	6	rapidly	rapidly	ADV
dti-1332	252	7	dividing	divide	VERB
dti-1332	252	8	cells	cell	NOUN
dti-1332	252	9	such	such	ADJ
dti-1332	252	10	as	as	ADP
dti-1332	252	11	cancerous	cancerous	ADJ
dti-1332	252	12	cells	cell	NOUN
dti-1332	252	13	,	,	PUNCT
dti-1332	252	14	as	as	SCONJ
dti-1332	252	15	the	the	DET
dti-1332	252	16	amount	amount	NOUN
dti-1332	252	17	of	of	ADP
dti-1332	252	18	sirna	sirna	PROPN
dti-1332	252	19	gets	get	VERB
dti-1332	252	20	exhausted	exhaust	VERB
dti-1332	252	21	with	with	ADP
dti-1332	252	22	the	the	DET
dti-1332	252	23	very	very	ADV
dti-1332	252	24	fast	fast	ADJ
dti-1332	252	25	cell	cell	NOUN
dti-1332	252	26	division	division	NOUN
dti-1332	252	27	.	.	PUNCT
dti-1332	253	1	also	also	ADV
dti-1332	253	2	,	,	PUNCT
dti-1332	253	3	sirnas	sirna	NOUN
dti-1332	253	4	have	have	VERB
dti-1332	253	5	very	very	ADV
dti-1332	253	6	short	short	ADJ
dti-1332	253	7	half	half	ADJ
dti-1332	253	8	-	-	PUNCT
dti-1332	253	9	life	life	NOUN
dti-1332	253	10	in	in	ADP
dti-1332	253	11	blood	blood	NOUN
dti-1332	253	12	and	and	CCONJ
dti-1332	253	13	mammalian	mammalian	ADJ
dti-1332	253	14	cells	cell	NOUN
dti-1332	253	15	poorly	poorly	ADV
dti-1332	253	16	take	take	VERB
dti-1332	253	17	them	they	PRON
dti-1332	253	18	.	.	PUNCT
dti-1332	254	1	the	the	DET
dti-1332	254	2	concentration	concentration	NOUN
dti-1332	254	3	of	of	ADP
dti-1332	254	4	sirna	sirna	PROPN
dti-1332	254	5	could	could	AUX
dti-1332	254	6	also	also	ADV
dti-1332	254	7	pose	pose	VERB
dti-1332	254	8	a	a	DET
dti-1332	254	9	problem	problem	NOUN
dti-1332	254	10	as	as	SCONJ
dti-1332	254	11	high	high	ADJ
dti-1332	254	12	concentration	concentration	NOUN
dti-1332	254	13	of	of	ADP
dti-1332	254	14	sirnas	sirna	NOUN
dti-1332	254	15	can	can	AUX
dti-1332	254	16	activate	activate	VERB
dti-1332	254	17	interferon	interferon	ADJ
dti-1332	254	18	response	response	NOUN
dti-1332	254	19	.	.	PUNCT
dti-1332	255	1	the	the	DET
dti-1332	255	2	solution	solution	NOUN
dti-1332	255	3	to	to	ADP
dti-1332	255	4	this	this	PRON
dti-1332	255	5	could	could	AUX
dti-1332	255	6	come	come	VERB
dti-1332	255	7	from	from	ADP
dti-1332	255	8	the	the	DET
dti-1332	255	9	use	use	NOUN
dti-1332	255	10	of	of	ADP
dti-1332	255	11	cationic	cationic	ADJ
dti-1332	255	12	nanoplex	nanoplex	PROPN
dti-1332	255	13	vectors	vector	NOUN
dti-1332	255	14	for	for	ADP
dti-1332	255	15	sirna	sirna	PROPN
dti-1332	255	16	delivery	delivery	NOUN
dti-1332	255	17	and	and	CCONJ
dti-1332	255	18	proper	proper	ADJ
dti-1332	255	19	control	control	NOUN
dti-1332	255	20	of	of	ADP
dti-1332	255	21	sirna	sirna	PROPN
dti-1332	255	22	concentration	concentration	NOUN
dti-1332	255	23	administered	administer	VERB
dti-1332	255	24	to	to	ADP
dti-1332	255	25	the	the	DET
dti-1332	255	26	cells	cell	NOUN
dti-1332	255	27	.	.	PUNCT
dti-1332	256	1	yet	yet	ADV
dti-1332	256	2	there	there	PRON
dti-1332	256	3	are	be	VERB
dti-1332	256	4	several	several	ADJ
dti-1332	256	5	questions	question	NOUN
dti-1332	256	6	still	still	ADV
dti-1332	256	7	unanswered	unanswered	ADJ
dti-1332	256	8	—	—	PUNCT
dti-1332	256	9	what	what	PRON
dti-1332	256	10	if	if	SCONJ
dti-1332	256	11	the	the	DET
dti-1332	256	12	nanoplex	nanoplex	NOUN
dti-1332	256	13	delivered	deliver	VERB
dti-1332	256	14	sirnas	sirna	NOUN
dti-1332	256	15	compete	compete	VERB
dti-1332	256	16	with	with	ADP
dti-1332	256	17	limited	limited	ADJ
dti-1332	256	18	amounts	amount	NOUN
dti-1332	256	19	of	of	ADP
dti-1332	256	20	enzyme	enzyme	NOUN
dti-1332	256	21	,	,	PUNCT
dti-1332	256	22	dicer	dicer	NOUN
dti-1332	256	23	and	and	CCONJ
dti-1332	256	24	risc	risc	PROPN
dti-1332	256	25	to	to	PART
dti-1332	256	26	interfere	interfere	VERB
dti-1332	256	27	with	with	ADP
dti-1332	256	28	endogenous	endogenous	ADJ
dti-1332	256	29	rnai	rnai	NOUN
dti-1332	256	30	pathways	pathway	NOUN
dti-1332	256	31	required	require	VERB
dti-1332	256	32	to	to	PART
dti-1332	256	33	maintain	maintain	VERB
dti-1332	256	34	the	the	DET
dti-1332	256	35	cell	cell	NOUN
dti-1332	256	36	in	in	ADP
dti-1332	256	37	its	its	PRON
dti-1332	256	38	differentiated	differentiated	ADJ
dti-1332	256	39	state	state	NOUN
dti-1332	256	40	?	?	PUNCT
dti-1332	257	1	what	what	PRON
dti-1332	257	2	are	be	AUX
dti-1332	257	3	its	its	PRON
dti-1332	257	4	possible	possible	ADJ
dti-1332	257	5	side	side	NOUN
dti-1332	257	6	effects	effect	NOUN
dti-1332	257	7	?	?	PUNCT
dti-1332	258	1	will	will	AUX
dti-1332	258	2	the	the	DET
dti-1332	258	3	mammalian	mammalian	ADJ
dti-1332	258	4	cell	cell	NOUN
dti-1332	258	5	take	take	VERB
dti-1332	258	6	the	the	DET
dti-1332	258	7	sirnas	sirna	NOUN
dti-1332	258	8	through	through	ADP
dti-1332	258	9	endocytosis	endocytosis	NOUN
dti-1332	258	10	so	so	ADV
dti-1332	258	11	easily	easily	ADV
dti-1332	258	12	?	?	PUNCT
dti-1332	259	1	how	how	SCONJ
dti-1332	259	2	long	long	ADV
dti-1332	259	3	does	do	AUX
dti-1332	259	4	the	the	DET
dti-1332	259	5	effect	effect	NOUN
dti-1332	259	6	last	last	ADV
dti-1332	259	7	?	?	PUNCT
dti-1332	260	1	the	the	DET
dti-1332	260	2	answers	answer	NOUN
dti-1332	260	3	may	may	AUX
dti-1332	260	4	start	start	VERB
dti-1332	260	5	coming	come	VERB
dti-1332	260	6	from	from	ADP
dti-1332	260	7	various	various	ADJ
dti-1332	260	8	clinical	clinical	ADJ
dti-1332	260	9	trials	trial	NOUN
dti-1332	260	10	,	,	PUNCT
dti-1332	260	11	probably	probably	ADV
dti-1332	260	12	in	in	ADP
dti-1332	260	13	cancer	cancer	NOUN
dti-1332	260	14	and	and	CCONJ
dti-1332	260	15	infectious	infectious	ADJ
dti-1332	260	16	diseases	disease	NOUN
dti-1332	260	17	,	,	PUNCT
dti-1332	260	18	provided	provide	VERB
dti-1332	260	19	that	that	SCONJ
dti-1332	260	20	developers	developer	NOUN
dti-1332	260	21	can	can	AUX
dti-1332	260	22	resolve	resolve	VERB
dti-1332	260	23	technical	technical	ADJ
dti-1332	260	24	challenges	challenge	NOUN
dti-1332	260	25	,	,	PUNCT
dti-1332	260	26	unwanted	unwanted	ADJ
dti-1332	260	27	cellular	cellular	ADJ
dti-1332	260	28	reactions	reaction	NOUN
dti-1332	260	29	,	,	PUNCT
dti-1332	260	30	compound	compound	NOUN
dti-1332	260	31	stability	stability	NOUN
dti-1332	260	32	,	,	PUNCT
dti-1332	260	33	and	and	CCONJ
dti-1332	260	34	delivery	delivery	NOUN
dti-1332	260	35	.	.	PUNCT
dti-1332	261	1	however	however	ADV
dti-1332	261	2	,	,	PUNCT
dti-1332	261	3	the	the	DET
dti-1332	261	4	future	future	ADJ
dti-1332	261	5	sirna	sirna	PROPN
dti-1332	261	6	delivery	delivery	NOUN
dti-1332	261	7	products	product	NOUN
dti-1332	261	8	include	include	VERB
dti-1332	261	9	nanoparticle	nanoparticle	NOUN
dti-1332	261	10	formulations	formulation	NOUN
dti-1332	261	11	containing	contain	VERB
dti-1332	261	12	various	various	ADJ
dti-1332	261	13	targeting	target	VERB
dti-1332	261	14	peptides	peptide	NOUN
dti-1332	261	15	and	and	CCONJ
dti-1332	261	16	endo	endo	NOUN
dti-1332	261	17	-	-	PUNCT
dti-1332	261	18	osomolytic	osomolytic	ADJ
dti-1332	261	19	polymers	polymer	NOUN
dti-1332	261	20	that	that	PRON
dti-1332	261	21	would	would	AUX
dti-1332	261	22	play	play	VERB
dti-1332	261	23	a	a	DET
dti-1332	261	24	vital	vital	ADJ
dti-1332	261	25	role	role	NOUN
dti-1332	261	26	in	in	ADP
dti-1332	261	27	treatment	treatment	NOUN
dti-1332	261	28	of	of	ADP
dti-1332	261	29	various	various	ADJ
dti-1332	261	30	diseases	disease	NOUN
dti-1332	261	31	and	and	CCONJ
dti-1332	261	32	disorders	disorder	NOUN
dti-1332	261	33	including	include	VERB
dti-1332	261	34	neurodegenerative	neurodegenerative	ADJ
dti-1332	261	35	diseases	disease	NOUN
dti-1332	261	36	.	.	PUNCT
dti-1332	262	1	nanotechnologies	nanotechnology	NOUN
dti-1332	262	2	have	have	AUX
dti-1332	262	3	enabled	enable	VERB
dti-1332	262	4	the	the	DET
dti-1332	262	5	development	development	NOUN
dti-1332	262	6	of	of	ADP
dti-1332	262	7	entirely	entirely	ADV
dti-1332	262	8	new	new	ADJ
dti-1332	262	9	drugs	drug	NOUN
dti-1332	262	10	and	and	CCONJ
dti-1332	262	11	altered	alter	VERB
dti-1332	262	12	the	the	DET
dti-1332	262	13	properties	property	NOUN
dti-1332	262	14	of	of	ADP
dti-1332	262	15	already	already	ADV
dti-1332	262	16	marketed	market	VERB
dti-1332	262	17	drugs	drug	NOUN
dti-1332	262	18	to	to	PART
dti-1332	262	19	create	create	VERB
dti-1332	262	20	potentially	potentially	ADV
dti-1332	262	21	safer	safe	ADJ
dti-1332	262	22	,	,	PUNCT
dti-1332	262	23	more	more	ADV
dti-1332	262	24	directed	directed	ADJ
dti-1332	262	25	and	and	CCONJ
dti-1332	262	26	effective	effective	ADJ
dti-1332	262	27	pharmaceuticals	pharmaceutical	NOUN
dti-1332	262	28	.	.	PUNCT
dti-1332	263	1	nanotechnology	nanotechnology	NOUN
dti-1332	263	2	enables	enable	VERB
dti-1332	263	3	intervention	intervention	NOUN
dti-1332	263	4	on	on	ADP
dti-1332	263	5	the	the	DET
dti-1332	263	6	level	level	NOUN
dti-1332	263	7	at	at	ADP
dti-1332	263	8	which	which	PRON
dti-1332	263	9	biological	biological	ADJ
dti-1332	263	10	systems	system	NOUN
dti-1332	263	11	actually	actually	ADV
dti-1332	263	12	operate	operate	VERB
dti-1332	263	13	.	.	PUNCT
dti-1332	264	1	pharmaceutical	pharmaceutical	ADJ
dti-1332	264	2	companies	company	NOUN
dti-1332	264	3	are	be	AUX
dti-1332	264	4	actively	actively	ADV
dti-1332	264	5	pursuing	pursue	VERB
dti-1332	264	6	this	this	DET
dti-1332	264	7	approach	approach	NOUN
dti-1332	264	8	of	of	ADP
dti-1332	264	9	using	use	VERB
dti-1332	264	10	nanotechnologies	nanotechnology	NOUN
dti-1332	264	11	that	that	PRON
dti-1332	264	12	can	can	AUX
dti-1332	264	13	perhaps	perhaps	ADV
dti-1332	264	14	revitalize	revitalize	VERB
dti-1332	264	15	drug	drug	NOUN
dti-1332	264	16	pipelines	pipeline	NOUN
dti-1332	264	17	to	to	PART
dti-1332	264	18	treat	treat	VERB
dti-1332	264	19	neurodegenerative	neurodegenerative	ADJ
dti-1332	264	20	diseases	disease	NOUN
dti-1332	264	21	like	like	ADP
dti-1332	264	22	ataxia	ataxia	NOUN
dti-1332	264	23	.	.	PUNCT
dti-1332	265	1	however	however	ADV
dti-1332	265	2	,	,	PUNCT
dti-1332	265	3	therapeutic	therapeutic	ADJ
dti-1332	265	4	approaches	approach	NOUN
dti-1332	265	5	need	need	VERB
dti-1332	265	6	to	to	PART
dti-1332	265	7	be	be	AUX
dti-1332	265	8	standardized	standardize	VERB
dti-1332	265	9	and	and	CCONJ
dti-1332	265	10	optimized	optimize	VERB
dti-1332	265	11	.	.	PUNCT
dti-1332	266	1	acknowledgements	acknowledgement	NOUN
dti-1332	266	2	we	we	PRON
dti-1332	266	3	acknowledge	acknowledge	VERB
dti-1332	266	4	the	the	DET
dti-1332	266	5	canadian	canadian	PROPN
dti-1332	266	6	institute	institute	PROPN
dti-1332	266	7	of	of	ADP
dti-1332	266	8	health	health	PROPN
dti-1332	266	9	research	research	PROPN
dti-1332	266	10	(	(	PUNCT
dti-1332	266	11	cihr	cihr	ADJ
dti-1332	266	12	)	)	PUNCT
dti-1332	266	13	grant	grant	NOUN
dti-1332	266	14	to	to	ADP
dti-1332	266	15	s.	s.	PROPN
dti-1332	266	16	prakash	prakash	PROPN
dti-1332	266	17	.	.	PUNCT
dti-1332	267	1	we	we	PRON
dti-1332	267	2	also	also	ADV
dti-1332	267	3	acknowledge	acknowledge	VERB
dti-1332	267	4	support	support	NOUN
dti-1332	267	5	of	of	ADP
dti-1332	267	6	mcgill	mcgill	PROPN
dti-1332	267	7	faculty	faculty	NOUN
dti-1332	267	8	of	of	ADP
dti-1332	267	9	medicine	medicine	NOUN
dti-1332	267	10	postgraduate	postgraduate	NOUN
dti-1332	267	11	scholarship	scholarship	NOUN
dti-1332	267	12	to	to	ADP
dti-1332	267	13	m.	m.	PROPN
dti-1332	267	14	malhotra	malhotra	PROPN
dti-1332	267	15	,	,	PUNCT
dti-1332	267	16	ms	ms	PROPN
dti-1332	267	17	.	.	PROPN
dti-1332	267	18	jasmine	jasmine	PROPN
dti-1332	267	19	bhathena	bhathena	PROPN
dti-1332	267	20	and	and	CCONJ
dti-1332	267	21	mr	mr	PROPN
dti-1332	267	22	.	.	PROPN
dti-1332	267	23	arun	arun	PROPN
dti-1332	267	24	kulamarva	kulamarva	PROPN
dti-1332	267	25	for	for	ADP
dti-1332	267	26	proof	proof	NOUN
dti-1332	267	27	-	-	PUNCT
dti-1332	267	28	reading	read	VERB
dti-1332	267	29	this	this	DET
dti-1332	267	30	article	article	NOUN
dti-1332	267	31	.	.	PUNCT
dti-1332	268	1	references	reference	NOUN
dti-1332	268	2	ahn	ahn	PROPN
dti-1332	268	3	,	,	PUNCT
dti-1332	268	4	c.h	c.h	PROPN
dti-1332	268	5	.	.	PROPN
dti-1332	268	6	,	,	PUNCT
dti-1332	268	7	chae	chae	PROPN
dti-1332	268	8	,	,	PUNCT
dti-1332	268	9	s.y	s.y	PROPN
dti-1332	268	10	.	.	PROPN
dti-1332	268	11	,	,	PUNCT
dti-1332	268	12	bae	bae	PROPN
dti-1332	268	13	,	,	PUNCT
dti-1332	268	14	y.h	y.h	PROPN
dti-1332	268	15	.	.	PROPN
dti-1332	268	16	et	et	PROPN
dti-1332	268	17	al	al	PROPN
dti-1332	268	18	.	.	PROPN
dti-1332	268	19	2002	2002	NUM
dti-1332	268	20	.	.	PUNCT
dti-1332	269	1	biodegradable	biodegradable	ADJ
dti-1332	269	2	poly(ethylenimine	poly(ethylenimine	PROPN
dti-1332	269	3	)	)	PUNCT
dti-1332	269	4	for	for	ADP
dti-1332	269	5	plasmid	plasmid	VERB
dti-1332	269	6	dna	dna	PROPN
dti-1332	269	7	delivery	delivery	NOUN
dti-1332	269	8	.	.	PUNCT
dti-1332	270	1	j.	j.	PROPN
dti-1332	270	2	controlled	control	VERB
dti-1332	270	3	release	release	PROPN
dti-1332	270	4	,	,	PUNCT
dti-1332	270	5	80:273–82	80:273–82	NOUN
dti-1332	270	6	.	.	PUNCT
dti-1332	271	1	alyautdin	alyautdin	PROPN
dti-1332	271	2	,	,	PUNCT
dti-1332	271	3	r.	r.	PROPN
dti-1332	271	4	,	,	PUNCT
dti-1332	271	5	gothier	gothier	NOUN
dti-1332	271	6	,	,	PUNCT
dti-1332	271	7	d.	d.	PROPN
dti-1332	271	8	,	,	PUNCT
dti-1332	271	9	petrov	petrov	PROPN
dti-1332	271	10	,	,	PUNCT
dti-1332	271	11	v.	v.	ADP
dti-1332	271	12	et	et	PROPN
dti-1332	271	13	al	al	PROPN
dti-1332	271	14	.	.	PROPN
dti-1332	271	15	1995	1995	NUM
dti-1332	271	16	.	.	PUNCT
dti-1332	272	1	analgesic	analgesic	ADJ
dti-1332	272	2	activity	activity	NOUN
dti-1332	272	3	of	of	ADP
dti-1332	272	4	the	the	DET
dti-1332	272	5	hexapeptide	hexapeptide	NOUN
dti-1332	272	6	dalargin	dalargin	NOUN
dti-1332	272	7	adsorbed	adsorb	VERB
dti-1332	272	8	on	on	ADP
dti-1332	272	9	the	the	DET
dti-1332	272	10	surface	surface	NOUN
dti-1332	272	11	of	of	ADP
dti-1332	272	12	polysorbate	polysorbate	NOUN
dti-1332	272	13	80	80	NUM
dti-1332	272	14	-	-	PUNCT
dti-1332	272	15	coated	coat	VERB
dti-1332	272	16	poly(butyl	poly(butyl	PROPN
dti-1332	272	17	cyanoacrylate	cyanoacrylate	NOUN
dti-1332	272	18	)	)	PUNCT
dti-1332	272	19	nanoparticles	nanoparticle	NOUN
dti-1332	272	20	.	.	PUNCT
dti-1332	273	1	journal	journal	NOUN
dti-1332	273	2	of	of	ADP
dti-1332	273	3	pharmaceutics	pharmaceutic	NOUN
dti-1332	273	4	and	and	CCONJ
dti-1332	273	5	biopharmaceutics	biopharmaceutic	NOUN
dti-1332	273	6	,	,	PUNCT
dti-1332	273	7	41:44–8	41:44–8	NUM
dti-1332	273	8	.	.	PUNCT
dti-1332	274	1	114	114	NUM
dti-1332	274	2	prakash	prakash	PROPN
dti-1332	274	3	and	and	CCONJ
dti-1332	274	4	malhotra	malhotra	PROPN
dti-1332	274	5	drug	drug	PROPN
dti-1332	274	6	target	target	NOUN
dti-1332	274	7	insights	insight	VERB
dti-1332	274	8	2008:3	2008:3	NUM
dti-1332	274	9	amarzguioui	amarzguioui	ADJ
dti-1332	274	10	,	,	PUNCT
dti-1332	274	11	m.	m.	NOUN
dti-1332	274	12	,	,	PUNCT
dti-1332	274	13	holen	holen	PROPN
dti-1332	274	14	,	,	PUNCT
dti-1332	274	15	t.	t.	PROPN
dti-1332	274	16	,	,	PUNCT
dti-1332	274	17	babaie	babaie	PROPN
dti-1332	274	18	,	,	PUNCT
dti-1332	274	19	e.	e.	PROPN
dti-1332	274	20	et	et	PROPN
dti-1332	274	21	al	al	PROPN
dti-1332	274	22	.	.	PROPN
dti-1332	274	23	2003	2003	NUM
dti-1332	274	24	.	.	PUNCT
dti-1332	275	1	tolerance	tolerance	NOUN
dti-1332	275	2	for	for	ADP
dti-1332	275	3	mutations	mutation	NOUN
dti-1332	275	4	and	and	CCONJ
dti-1332	275	5	chemical	chemical	NOUN
dti-1332	275	6	modifi	modifi	NOUN
dti-1332	275	7	cations	cation	NOUN
dti-1332	275	8	in	in	ADP
dti-1332	275	9	a	a	DET
dti-1332	275	10	sirna	sirna	PROPN
dti-1332	275	11	.	.	PUNCT
dti-1332	276	1	nucleic	nucleic	ADJ
dti-1332	276	2	acids	acid	NOUN
dti-1332	276	3	research	research	NOUN
dti-1332	276	4	,	,	PUNCT
dti-1332	276	5	31:589–95	31:589–95	NOUN
dti-1332	276	6	.	.	PUNCT
dti-1332	277	1	bahl	bahl	PROPN
dti-1332	277	2	,	,	PUNCT
dti-1332	277	3	s.	s.	PROPN
dti-1332	277	4	,	,	PUNCT
dti-1332	277	5	virdi	virdi	PROPN
dti-1332	277	6	,	,	PUNCT
dti-1332	277	7	k.	k.	PROPN
dti-1332	277	8	,	,	PUNCT
dti-1332	277	9	mittal	mittal	PROPN
dti-1332	277	10	,	,	PUNCT
dti-1332	277	11	u.	u.	PROPN
dti-1332	277	12	et	et	PROPN
dti-1332	277	13	al	al	PROPN
dti-1332	277	14	.	.	PROPN
dti-1332	277	15	2005	2005	NUM
dti-1332	277	16	.	.	PUNCT
dti-1332	278	1	evidence	evidence	NOUN
dti-1332	278	2	of	of	ADP
dti-1332	278	3	a	a	DET
dti-1332	278	4	common	common	ADJ
dti-1332	278	5	founder	founder	NOUN
dti-1332	278	6	for	for	ADP
dti-1332	278	7	sca12	sca12	NOUN
dti-1332	278	8	in	in	ADP
dti-1332	278	9	the	the	DET
dti-1332	278	10	indian	indian	ADJ
dti-1332	278	11	population	population	NOUN
dti-1332	278	12	.	.	PUNCT
dti-1332	279	1	ann	ann	PROPN
dti-1332	279	2	.	.	PUNCT
dti-1332	279	3	hum	hum	PROPN
dti-1332	279	4	.	.	PUNCT
dti-1332	280	1	genet	genet	PROPN
dti-1332	280	2	.	.	PUNCT
dti-1332	280	3	,	,	PUNCT
dti-1332	280	4	69:528–34	69:528–34	NOUN
dti-1332	280	5	.	.	PUNCT
dti-1332	281	1	behlke	behlke	PROPN
dti-1332	281	2	,	,	PUNCT
dti-1332	281	3	m.a	m.a	PROPN
dti-1332	281	4	.	.	PROPN
dti-1332	281	5	2006	2006	NUM
dti-1332	281	6	.	.	PUNCT
dti-1332	282	1	progress	progress	NOUN
dti-1332	282	2	towards	towards	ADP
dti-1332	282	3	in	in	ADP
dti-1332	282	4	vivo	vivo	ADJ
dti-1332	282	5	use	use	NOUN
dti-1332	282	6	of	of	ADP
dti-1332	282	7	sirnas	sirnas	PROPN
dti-1332	282	8	.	.	PUNCT
dti-1332	283	1	mol	mol	PROPN
dti-1332	283	2	.	.	PROPN
dti-1332	284	1	ther	ther	PROPN
dti-1332	284	2	.	.	PUNCT
dti-1332	284	3	,	,	PUNCT
dti-1332	284	4	13:644–70	13:644–70	PROPN
dti-1332	284	5	.	.	PUNCT
dti-1332	285	1	bernstein	bernstein	PROPN
dti-1332	285	2	,	,	PUNCT
dti-1332	285	3	e.	e.	PROPN
dti-1332	285	4	,	,	PUNCT
dti-1332	285	5	caudy	caudy	PROPN
dti-1332	285	6	,	,	PUNCT
dti-1332	285	7	a.a	a.a	PROPN
dti-1332	285	8	.	.	PROPN
dti-1332	285	9	,	,	PUNCT
dti-1332	285	10	hammond	hammond	PROPN
dti-1332	285	11	,	,	PUNCT
dti-1332	285	12	s.a	s.a	PROPN
dti-1332	285	13	.	.	PROPN
dti-1332	285	14	and	and	CCONJ
dti-1332	285	15	hanon	hanon	PROPN
dti-1332	285	16	,	,	PUNCT
dti-1332	285	17	g.j	g.j	PROPN
dti-1332	285	18	.	.	PROPN
dti-1332	285	19	2001	2001	NUM
dti-1332	285	20	.	.	PUNCT
dti-1332	286	1	role	role	NOUN
dti-1332	286	2	for	for	ADP
dti-1332	286	3	a	a	DET
dti-1332	286	4	bidentate	bidentate	NOUN
dti-1332	286	5	ribonuclease	ribonuclease	NOUN
dti-1332	286	6	in	in	ADP
dti-1332	286	7	the	the	DET
dti-1332	286	8	initiation	initiation	NOUN
dti-1332	286	9	step	step	NOUN
dti-1332	286	10	of	of	ADP
dti-1332	286	11	rna	rna	NOUN
dti-1332	286	12	interference	interference	NOUN
dti-1332	286	13	.	.	PUNCT
dti-1332	287	1	nature	nature	NOUN
dti-1332	287	2	,	,	PUNCT
dti-1332	287	3	409:363–6	409:363–6	NUM
dti-1332	287	4	.	.	PUNCT
dti-1332	288	1	bird	bird	PROPN
dti-1332	288	2	,	,	PUNCT
dti-1332	288	3	t.d	t.d	PROPN
dti-1332	288	4	.	.	PROPN
dti-1332	288	5	gene	gene	NOUN
dti-1332	288	6	reviews	review	NOUN
dti-1332	288	7	.	.	PUNCT
dti-1332	289	1	2008	2008	NUM
dti-1332	289	2	.	.	PUNCT
dti-1332	290	1	hereditary	hereditary	ADJ
dti-1332	290	2	ataxia	ataxia	NOUN
dti-1332	290	3	overview	overview	NOUN
dti-1332	290	4	.	.	PUNCT
dti-1332	291	1	accessed	access	VERB
dti-1332	291	2	4	4	NUM
dti-1332	291	3	march	march	NOUN
dti-1332	291	4	2008	2008	NUM
dti-1332	291	5	.	.	PUNCT
dti-1332	292	1	url	url	PROPN
dti-1332	292	2	:	:	PUNCT
dti-1332	292	3	http://www.geneclinics.org/profi	http://www.geneclinics.org/profi	PROPN
dti-1332	292	4	les	les	PROPN
dti-1332	292	5	/	/	SYM
dti-1332	292	6	ataxias.html	ataxias.html	PROPN
dti-1332	292	7	.	.	PUNCT
dti-1332	293	1	brkanac	brkanac	PROPN
dti-1332	293	2	,	,	PUNCT
dti-1332	293	3	z.	z.	PROPN
dti-1332	293	4	,	,	PUNCT
dti-1332	293	5	bylenok	bylenok	PROPN
dti-1332	293	6	,	,	PUNCT
dti-1332	293	7	l.	l.	PROPN
dti-1332	293	8	,	,	PUNCT
dti-1332	293	9	fernandez	fernandez	PROPN
dti-1332	293	10	,	,	PUNCT
dti-1332	293	11	m.	m.	NOUN
dti-1332	293	12	et	et	PROPN
dti-1332	293	13	al	al	PROPN
dti-1332	293	14	.	.	PROPN
dti-1332	293	15	2002	2002	NUM
dti-1332	293	16	.	.	PUNCT
dti-1332	294	1	a	a	DET
dti-1332	294	2	new	new	ADJ
dti-1332	294	3	dominant	dominant	ADJ
dti-1332	294	4	spinocerebellar	spinocerebellar	NOUN
dti-1332	294	5	ataxia	ataxia	NOUN
dti-1332	294	6	linked	link	VERB
dti-1332	294	7	to	to	PART
dti-1332	294	8	chromosome	chromosome	VERB
dti-1332	294	9	19q13.4	19q13.4	NUM
dti-1332	294	10	-	-	PUNCT
dti-1332	294	11	qter	qter	NOUN
dti-1332	294	12	.	.	PUNCT
dti-1332	295	1	arch	arch	PROPN
dti-1332	295	2	.	.	PUNCT
dti-1332	296	1	neurol	neurol	NOUN
dti-1332	296	2	.	.	PUNCT
dti-1332	296	3	,	,	PUNCT
dti-1332	296	4	59:1291–5	59:1291–5	NUM
dti-1332	296	5	.	.	PUNCT
dti-1332	297	1	brusse	brusse	PROPN
dti-1332	297	2	,	,	PUNCT
dti-1332	297	3	e.	e.	PROPN
dti-1332	297	4	,	,	PUNCT
dti-1332	297	5	de	de	PROPN
dti-1332	297	6	koning	koning	PROPN
dti-1332	297	7	,	,	PUNCT
dti-1332	297	8	i.	i.	PROPN
dti-1332	297	9	,	,	PUNCT
dti-1332	297	10	maat	maat	PROPN
dti-1332	297	11	-	-	PUNCT
dti-1332	297	12	kievit	kievit	PROPN
dti-1332	297	13	,	,	PUNCT
dti-1332	297	14	a.	a.	PROPN
dti-1332	297	15	et	et	PROPN
dti-1332	297	16	al	al	PROPN
dti-1332	297	17	.	.	PROPN
dti-1332	297	18	2006	2006	NUM
dti-1332	297	19	.	.	PUNCT
dti-1332	298	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	298	2	ataxia	ataxia	NOUN
dti-1332	298	3	associated	associate	VERB
dti-1332	298	4	with	with	ADP
dti-1332	298	5	a	a	DET
dti-1332	298	6	mutation	mutation	NOUN
dti-1332	298	7	in	in	ADP
dti-1332	298	8	the	the	DET
dti-1332	298	9	fi	fi	NOUN
dti-1332	298	10	broblast	broblast	ADJ
dti-1332	298	11	growth	growth	NOUN
dti-1332	298	12	factor	factor	NOUN
dti-1332	298	13	14	14	NUM
dti-1332	298	14	gene	gene	NOUN
dti-1332	298	15	(	(	PUNCT
dti-1332	298	16	sca27	sca27	PROPN
dti-1332	298	17	):	):	PUNCT
dti-1332	298	18	a	a	DET
dti-1332	298	19	new	new	ADJ
dti-1332	298	20	phenotype	phenotype	NOUN
dti-1332	298	21	.	.	PUNCT
dti-1332	299	1	mov	mov	NOUN
dti-1332	299	2	.	.	PUNCT
dti-1332	299	3	disord	disord	PROPN
dti-1332	299	4	.	.	PUNCT
dti-1332	299	5	,	,	PUNCT
dti-1332	300	1	21:396–401	21:396–401	PROPN
dti-1332	300	2	.	.	PUNCT
dti-1332	301	1	brummelkamp	brummelkamp	PROPN
dti-1332	301	2	,	,	PUNCT
dti-1332	301	3	t.r	t.r	PROPN
dti-1332	301	4	.	.	PROPN
dti-1332	301	5	,	,	PUNCT
dti-1332	301	6	bernards	bernard	NOUN
dti-1332	301	7	,	,	PUNCT
dti-1332	301	8	r.	r.	PROPN
dti-1332	301	9	and	and	CCONJ
dti-1332	301	10	agami	agami	PROPN
dti-1332	301	11	,	,	PUNCT
dti-1332	301	12	r.	r.	PROPN
dti-1332	301	13	2002	2002	NUM
dti-1332	301	14	.	.	PUNCT
dti-1332	302	1	a	a	DET
dti-1332	302	2	system	system	NOUN
dti-1332	302	3	for	for	ADP
dti-1332	302	4	stable	stable	ADJ
dti-1332	302	5	expression	expression	NOUN
dti-1332	302	6	of	of	ADP
dti-1332	302	7	short	short	ADJ
dti-1332	302	8	interfering	interfere	VERB
dti-1332	302	9	rnas	rna	NOUN
dti-1332	302	10	in	in	ADP
dti-1332	302	11	mammalian	mammalian	ADJ
dti-1332	302	12	cells	cell	NOUN
dti-1332	302	13	.	.	PUNCT
dti-1332	303	1	science	science	NOUN
dti-1332	303	2	,	,	PUNCT
dti-1332	303	3	296:550–3	296:550–3	NUM
dti-1332	303	4	.	.	PUNCT
dti-1332	303	5	buckingham	buckingham	PROPN
dti-1332	303	6	,	,	PUNCT
dti-1332	303	7	s.d	s.d	PROPN
dti-1332	303	8	.	.	PROPN
dti-1332	303	9	,	,	PUNCT
dti-1332	303	10	esmaeili	esmaeili	PROPN
dti-1332	303	11	,	,	PUNCT
dti-1332	303	12	b.	b.	PROPN
dti-1332	303	13	,	,	PUNCT
dti-1332	303	14	wood	wood	NOUN
dti-1332	303	15	,	,	PUNCT
dti-1332	303	16	m.	m.	NOUN
dti-1332	303	17	et	et	PROPN
dti-1332	303	18	al	al	PROPN
dti-1332	303	19	.	.	PROPN
dti-1332	303	20	2004	2004	NUM
dti-1332	303	21	.	.	PUNCT
dti-1332	304	1	rna	rna	NOUN
dti-1332	304	2	interference	interference	NOUN
dti-1332	304	3	:	:	PUNCT
dti-1332	304	4	from	from	ADP
dti-1332	304	5	model	model	NOUN
dti-1332	304	6	organisms	organism	NOUN
dti-1332	304	7	towards	towards	ADP
dti-1332	304	8	therapy	therapy	NOUN
dti-1332	304	9	for	for	ADP
dti-1332	304	10	neural	neural	ADJ
dti-1332	304	11	and	and	CCONJ
dti-1332	304	12	neuromuscular	neuromuscular	ADJ
dti-1332	304	13	disorders	disorder	NOUN
dti-1332	304	14	.	.	PUNCT
dti-1332	305	1	human	human	ADJ
dti-1332	305	2	molecular	molecular	ADJ
dti-1332	305	3	genetics	genetic	NOUN
dti-1332	305	4	,	,	PUNCT
dti-1332	305	5	13(2):275–88	13(2):275–88	NUM
dti-1332	305	6	.	.	PUNCT
dti-1332	305	7	buhmann	buhmann	PROPN
dti-1332	305	8	,	,	PUNCT
dti-1332	305	9	c.	c.	PROPN
dti-1332	305	10	,	,	PUNCT
dti-1332	305	11	bussopulos	bussopulo	VERB
dti-1332	305	12	,	,	PUNCT
dti-1332	305	13	a.	a.	NOUN
dti-1332	305	14	and	and	CCONJ
dti-1332	305	15	oechsner	oechsner	ADV
dti-1332	305	16	,	,	PUNCT
dti-1332	305	17	m.	m.	NOUN
dti-1332	305	18	2003	2003	NUM
dti-1332	305	19	.	.	PUNCT
dti-1332	306	1	dopaminergic	dopaminergic	ADJ
dti-1332	306	2	response	response	NOUN
dti-1332	306	3	in	in	ADP
dti-1332	306	4	parkinsonian	parkinsonian	ADJ
dti-1332	306	5	phenotype	phenotype	NOUN
dti-1332	306	6	of	of	ADP
dti-1332	306	7	machado	machado	PROPN
dti-1332	306	8	joseph	joseph	PROPN
dti-1332	306	9	disease	disease	PROPN
dti-1332	306	10	.	.	PUNCT
dti-1332	307	1	mov	mov	NOUN
dti-1332	307	2	.	.	PUNCT
dti-1332	307	3	disord	disord	PROPN
dti-1332	307	4	.	.	PUNCT
dti-1332	307	5	,	,	PUNCT
dti-1332	307	6	18:219–21	18:219–21	PROPN
dti-1332	307	7	.	.	PUNCT
dti-1332	308	1	burger	burger	NOUN
dti-1332	308	2	,	,	PUNCT
dti-1332	308	3	c.	c.	PROPN
dti-1332	308	4	,	,	PUNCT
dti-1332	308	5	gorbatyuk	gorbatyuk	PROPN
dti-1332	308	6	,	,	PUNCT
dti-1332	308	7	o.s	o.s	PROPN
dti-1332	308	8	.	.	PROPN
dti-1332	308	9	,	,	PUNCT
dti-1332	308	10	velardo	velardo	PROPN
dti-1332	308	11	,	,	PUNCT
dti-1332	308	12	m.j	m.j	PROPN
dti-1332	308	13	.	.	PROPN
dti-1332	308	14	et	et	PROPN
dti-1332	308	15	al	al	PROPN
dti-1332	308	16	.	.	PROPN
dti-1332	308	17	2004	2004	NUM
dti-1332	308	18	.	.	PUNCT
dti-1332	309	1	recombinant	recombinant	ADJ
dti-1332	309	2	aav	aav	PROPN
dti-1332	309	3	viral	viral	ADJ
dti-1332	309	4	vectors	vector	NOUN
dti-1332	309	5	psedotyped	psedotype	VERB
dti-1332	309	6	with	with	ADP
dti-1332	309	7	viral	viral	ADJ
dti-1332	309	8	capsids	capsid	NOUN
dti-1332	309	9	from	from	ADP
dti-1332	309	10	serotypes	serotype	NOUN
dti-1332	309	11	1	1	NUM
dti-1332	309	12	,	,	PUNCT
dti-1332	309	13	2	2	NUM
dti-1332	309	14	and	and	CCONJ
dti-1332	309	15	5	5	NUM
dti-1332	309	16	display	display	NOUN
dti-1332	309	17	differential	differential	NOUN
dti-1332	309	18	effi	effi	PROPN
dti-1332	309	19	ciency	ciency	NOUN
dti-1332	309	20	and	and	CCONJ
dti-1332	309	21	cell	cell	NOUN
dti-1332	309	22	tropism	tropism	NOUN
dti-1332	309	23	after	after	ADP
dti-1332	309	24	delivery	delivery	NOUN
dti-1332	309	25	to	to	ADP
dti-1332	309	26	different	different	ADJ
dti-1332	309	27	regions	region	NOUN
dti-1332	309	28	of	of	ADP
dti-1332	309	29	the	the	DET
dti-1332	309	30	central	central	ADJ
dti-1332	309	31	nervous	nervous	ADJ
dti-1332	309	32	system	system	NOUN
dti-1332	309	33	.	.	PUNCT
dti-1332	310	1	mol	mol	PROPN
dti-1332	310	2	.	.	PROPN
dti-1332	311	1	ther	ther	PROPN
dti-1332	311	2	.	.	PUNCT
dti-1332	311	3	,	,	PUNCT
dti-1332	311	4	10:302–17	10:302–17	PROPN
dti-1332	311	5	.	.	PUNCT
dti-1332	312	1	burright	burright	PROPN
dti-1332	312	2	,	,	PUNCT
dti-1332	312	3	e.n	e.n	PROPN
dti-1332	312	4	.	.	PROPN
dti-1332	312	5	,	,	PUNCT
dti-1332	312	6	clark	clark	PROPN
dti-1332	312	7	,	,	PUNCT
dti-1332	312	8	h.b	h.b	PROPN
dti-1332	312	9	.	.	PROPN
dti-1332	312	10	,	,	PUNCT
dti-1332	312	11	servadio	servadio	NOUN
dti-1332	312	12	,	,	PUNCT
dti-1332	312	13	a.	a.	NOUN
dti-1332	312	14	et	et	PROPN
dti-1332	312	15	al	al	PROPN
dti-1332	312	16	.	.	PROPN
dti-1332	312	17	1995	1995	NUM
dti-1332	312	18	.	.	PUNCT
dti-1332	313	1	sca1	sca1	NOUN
dti-1332	313	2	transgenic	transgenic	NOUN
dti-1332	313	3	mice	mouse	NOUN
dti-1332	313	4	:	:	PUNCT
dti-1332	313	5	a	a	DET
dti-1332	313	6	model	model	NOUN
dti-1332	313	7	for	for	ADP
dti-1332	313	8	neurodegeneration	neurodegeneration	NOUN
dti-1332	313	9	caused	cause	VERB
dti-1332	313	10	by	by	ADP
dti-1332	313	11	an	an	DET
dti-1332	313	12	expanded	expand	VERB
dti-1332	313	13	cag	cag	PROPN
dti-1332	313	14	trinucleotide	trinucleotide	NOUN
dti-1332	313	15	repeat	repeat	NOUN
dti-1332	313	16	.	.	PUNCT
dti-1332	314	1	cell	cell	NOUN
dti-1332	314	2	.	.	PUNCT
dti-1332	314	3	,	,	PUNCT
dti-1332	314	4	82:937–48	82:937–48	PROPN
dti-1332	314	5	.	.	PUNCT
dti-1332	315	1	cagnoli	cagnoli	PROPN
dti-1332	315	2	,	,	PUNCT
dti-1332	315	3	c.	c.	PROPN
dti-1332	315	4	,	,	PUNCT
dti-1332	315	5	mariotti	mariotti	PROPN
dti-1332	315	6	,	,	PUNCT
dti-1332	315	7	c.	c.	PROPN
dti-1332	315	8	,	,	PUNCT
dti-1332	315	9	taroni	taroni	NOUN
dti-1332	315	10	,	,	PUNCT
dti-1332	315	11	f.	f.	PROPN
dti-1332	315	12	et	et	PROPN
dti-1332	315	13	al	al	PROPN
dti-1332	315	14	.	.	PROPN
dti-1332	316	1	2006	2006	NUM
dti-1332	316	2	.	.	PUNCT
dti-1332	317	1	sca28	sca28	PROPN
dti-1332	317	2	,	,	PUNCT
dti-1332	317	3	a	a	DET
dti-1332	317	4	novel	novel	ADJ
dti-1332	317	5	form	form	NOUN
dti-1332	317	6	of	of	ADP
dti-1332	317	7	autosomal	autosomal	ADJ
dti-1332	317	8	dominant	dominant	ADJ
dti-1332	317	9	cerebellar	cerebellar	ADJ
dti-1332	317	10	ataxia	ataxia	NOUN
dti-1332	317	11	on	on	ADP
dti-1332	317	12	chromosome	chromosome	NOUN
dti-1332	317	13	18p11.22q11.2	18p11.22q11.2	NUM
dti-1332	317	14	.	.	PUNCT
dti-1332	318	1	brain	brain	PROPN
dti-1332	318	2	,	,	PUNCT
dti-1332	318	3	129:235–42	129:235–42	PROPN
dti-1332	318	4	.	.	PUNCT
dti-1332	318	5	cancel	cancel	PROPN
dti-1332	318	6	,	,	PUNCT
dti-1332	318	7	g.	g.	NOUN
dti-1332	318	8	,	,	PUNCT
dti-1332	318	9	durr	durr	NOUN
dti-1332	318	10	,	,	PUNCT
dti-1332	318	11	a.	a.	NOUN
dti-1332	318	12	,	,	PUNCT
dti-1332	318	13	didierjean	didierjean	ADJ
dti-1332	318	14	,	,	PUNCT
dti-1332	318	15	o.	o.	PROPN
dti-1332	318	16	et	et	PROPN
dti-1332	318	17	al	al	PROPN
dti-1332	318	18	.	.	PROPN
dti-1332	318	19	1997	1997	NUM
dti-1332	318	20	.	.	PUNCT
dti-1332	319	1	molecular	molecular	ADJ
dti-1332	319	2	and	and	CCONJ
dti-1332	319	3	clinical	clinical	ADJ
dti-1332	319	4	correlations	correlation	NOUN
dti-1332	319	5	in	in	ADP
dti-1332	319	6	spinocerebellar	spinocerebellar	ADJ
dti-1332	319	7	ataxia	ataxia	NOUN
dti-1332	319	8	2	2	NUM
dti-1332	319	9	:	:	PUNCT
dti-1332	319	10	a	a	DET
dti-1332	319	11	study	study	NOUN
dti-1332	319	12	of	of	ADP
dti-1332	319	13	32	32	NUM
dti-1332	319	14	families	family	NOUN
dti-1332	319	15	.	.	PUNCT
dti-1332	320	1	hum	hum	ADJ
dti-1332	320	2	.	.	PUNCT
dti-1332	321	1	mol	mol	PROPN
dti-1332	321	2	.	.	PUNCT
dti-1332	321	3	genet	genet	PROPN
dti-1332	321	4	.	.	PUNCT
dti-1332	322	1	,	,	PUNCT
dti-1332	322	2	6:709–15	6:709–15	PROPN
dti-1332	322	3	.	.	PUNCT
dti-1332	323	1	caplen	caplen	PROPN
dti-1332	323	2	,	,	PUNCT
dti-1332	323	3	n.j	n.j	PROPN
dti-1332	323	4	.	.	PROPN
dti-1332	323	5	,	,	PUNCT
dti-1332	323	6	taylor	taylor	PROPN
dti-1332	323	7	,	,	PUNCT
dti-1332	323	8	j.p	j.p	PROPN
dti-1332	323	9	.	.	PROPN
dti-1332	323	10	,	,	PUNCT
dti-1332	323	11	stathem	stathem	PROPN
dti-1332	323	12	,	,	PUNCT
dti-1332	323	13	v.s.	v.s.	X
dti-1332	323	14	et	et	PROPN
dti-1332	323	15	al	al	PROPN
dti-1332	323	16	.	.	PROPN
dti-1332	323	17	2002	2002	NUM
dti-1332	323	18	.	.	PUNCT
dti-1332	324	1	rescue	rescue	NOUN
dti-1332	324	2	of	of	ADP
dti-1332	324	3	polyglutamine	polyglutamine	NOUN
dti-1332	324	4	-	-	PUNCT
dti-1332	324	5	mediated	mediate	VERB
dti-1332	324	6	cytotoxicity	cytotoxicity	NOUN
dti-1332	324	7	by	by	ADP
dti-1332	324	8	double	double	ADJ
dti-1332	324	9	-	-	PUNCT
dti-1332	324	10	stranded	strand	VERB
dti-1332	324	11	rna	rna	NOUN
dti-1332	324	12	-	-	PUNCT
dti-1332	324	13	mediated	mediate	VERB
dti-1332	324	14	rna	rna	NOUN
dti-1332	324	15	interference	interference	NOUN
dti-1332	324	16	.	.	PUNCT
dti-1332	325	1	hum	hum	PROPN
dti-1332	325	2	.	.	PUNCT
dti-1332	326	1	mol	mol	PROPN
dti-1332	326	2	.	.	PUNCT
dti-1332	327	1	genet	genet	PROPN
dti-1332	327	2	.	.	PUNCT
dti-1332	328	1	,	,	PUNCT
dti-1332	328	2	11:175–84	11:175–84	NOUN
dti-1332	328	3	.	.	PUNCT
dti-1332	329	1	chen	chen	PROPN
dti-1332	329	2	,	,	PUNCT
dti-1332	329	3	d.h	d.h	PROPN
dti-1332	329	4	.	.	PROPN
dti-1332	329	5	,	,	PUNCT
dti-1332	329	6	cimino	cimino	PROPN
dti-1332	329	7	,	,	PUNCT
dti-1332	329	8	p.j	p.j	PROPN
dti-1332	329	9	.	.	PROPN
dti-1332	329	10	,	,	PUNCT
dti-1332	329	11	ranum	ranum	ADJ
dti-1332	329	12	,	,	PUNCT
dti-1332	329	13	l.	l.	PROPN
dti-1332	329	14	et	et	PROPN
dti-1332	329	15	al	al	PROPN
dti-1332	329	16	.	.	PROPN
dti-1332	329	17	2003	2003	NUM
dti-1332	329	18	.	.	PUNCT
dti-1332	330	1	prevalence	prevalence	NOUN
dti-1332	330	2	of	of	ADP
dti-1332	330	3	sca	sca	PROPN
dti-1332	330	4	14	14	NUM
dti-1332	330	5	and	and	CCONJ
dti-1332	330	6	spectrum	spectrum	NOUN
dti-1332	330	7	of	of	ADP
dti-1332	330	8	pkcy	pkcy	NOUN
dti-1332	330	9	mutations	mutation	NOUN
dti-1332	330	10	in	in	ADP
dti-1332	330	11	a	a	DET
dti-1332	330	12	large	large	ADJ
dti-1332	330	13	panel	panel	NOUN
dti-1332	330	14	of	of	ADP
dti-1332	330	15	ataxia	ataxia	NOUN
dti-1332	330	16	patients	patient	NOUN
dti-1332	330	17	.	.	PUNCT
dti-1332	331	1	am	be	AUX
dti-1332	331	2	.	.	PUNCT
dti-1332	332	1	j.	j.	PROPN
dti-1332	332	2	hum	hum	PROPN
dti-1332	332	3	.	.	PUNCT
dti-1332	333	1	genet	genet	PROPN
dti-1332	333	2	.	.	PUNCT
dti-1332	333	3	,	,	PUNCT
dti-1332	333	4	73:546	73:546	NUM
dti-1332	333	5	.	.	PUNCT
dti-1332	334	1	chen	chen	PROPN
dti-1332	334	2	,	,	PUNCT
dti-1332	334	3	s.	s.	PROPN
dti-1332	334	4	,	,	PUNCT
dti-1332	334	5	ferrone	ferrone	NOUN
dti-1332	334	6	,	,	PUNCT
dti-1332	334	7	f.a	f.a	PROPN
dti-1332	334	8	.	.	PROPN
dti-1332	334	9	and	and	CCONJ
dti-1332	334	10	wetzel	wetzel	PROPN
dti-1332	334	11	,	,	PUNCT
dti-1332	334	12	r.	r.	PROPN
dti-1332	334	13	2002	2002	NUM
dti-1332	334	14	.	.	PUNCT
dti-1332	335	1	huntington‘s	huntington‘s	PROPN
dti-1332	335	2	disease	disease	NOUN
dti-1332	335	3	age	age	NOUN
dti-1332	335	4	-	-	PUNCT
dti-1332	335	5	ofonset	ofonset	NOUN
dti-1332	335	6	linked	link	VERB
dti-1332	335	7	to	to	ADP
dti-1332	335	8	polyglutamine	polyglutamine	NOUN
dti-1332	335	9	aggregation	aggregation	NOUN
dti-1332	335	10	nucleation	nucleation	NOUN
dti-1332	335	11	.	.	PUNCT
dti-1332	336	1	proc	proc	NOUN
dti-1332	336	2	.	.	PUNCT
dti-1332	337	1	natl	natl	PROPN
dti-1332	337	2	.	.	PUNCT
dti-1332	338	1	acad	acad	PROPN
dti-1332	338	2	.	.	PUNCT
dti-1332	339	1	sci	sci	PROPN
dti-1332	339	2	.	.	PUNCT
dti-1332	339	3	u.s.a	u.s.a	PROPN
dti-1332	339	4	.	.	PROPN
dti-1332	339	5	,	,	PUNCT
dti-1332	339	6	99:11884–9	99:11884–9	X
dti-1332	339	7	.	.	PUNCT
dti-1332	340	1	chow	chow	PROPN
dti-1332	340	2	,	,	PUNCT
dti-1332	340	3	m.k	m.k	PROPN
dti-1332	340	4	.	.	PROPN
dti-1332	340	5	,	,	PUNCT
dti-1332	340	6	ellisdon	ellisdon	PROPN
dti-1332	340	7	,	,	PUNCT
dti-1332	340	8	a.m.	a.m.	ADV
dti-1332	340	9	,	,	PUNCT
dti-1332	340	10	cabrita	cabrita	PROPN
dti-1332	340	11	,	,	PUNCT
dti-1332	340	12	l.d	l.d	PROPN
dti-1332	340	13	.	.	PROPN
dti-1332	340	14	et	et	PROPN
dti-1332	341	1	al	al	PROPN
dti-1332	341	2	.	.	PROPN
dti-1332	341	3	2004	2004	NUM
dti-1332	341	4	.	.	PUNCT
dti-1332	342	1	polyglutamine	polyglutamine	NOUN
dti-1332	342	2	expansion	expansion	NOUN
dti-1332	342	3	in	in	ADP
dti-1332	342	4	ataxin-3	ataxin-3	PROPN
dti-1332	342	5	does	do	AUX
dti-1332	342	6	not	not	PART
dti-1332	342	7	affect	affect	VERB
dti-1332	342	8	protein	protein	NOUN
dti-1332	342	9	stability	stability	NOUN
dti-1332	342	10	:	:	PUNCT
dti-1332	342	11	implications	implication	NOUN
dti-1332	342	12	for	for	ADP
dti-1332	342	13	misfolding	misfolding	NOUN
dti-1332	342	14	and	and	CCONJ
dti-1332	342	15	disease	disease	NOUN
dti-1332	342	16	.	.	PUNCT
dti-1332	343	1	j.	j.	PROPN
dti-1332	343	2	biol	biol	PROPN
dti-1332	343	3	.	.	PUNCT
dti-1332	344	1	chem	chem	PROPN
dti-1332	344	2	.	.	PUNCT
dti-1332	344	3	,	,	PUNCT
dti-1332	344	4	279:47643–51	279:47643–51	NUM
dti-1332	344	5	.	.	PUNCT
dti-1332	345	1	chung	chung	PROPN
dti-1332	345	2	,	,	PUNCT
dti-1332	345	3	m.y	m.y	PROPN
dti-1332	345	4	.	.	PROPN
dti-1332	345	5	,	,	PUNCT
dti-1332	345	6	lu	lu	PROPN
dti-1332	345	7	,	,	PUNCT
dti-1332	345	8	y.c	y.c	PROPN
dti-1332	345	9	.	.	PROPN
dti-1332	345	10	,	,	PUNCT
dti-1332	345	11	cheng	cheng	PROPN
dti-1332	345	12	,	,	PUNCT
dti-1332	345	13	n.c	n.c	PROPN
dti-1332	345	14	.	.	PROPN
dti-1332	345	15	et	et	PROPN
dti-1332	345	16	al	al	PROPN
dti-1332	345	17	.	.	PROPN
dti-1332	345	18	2003	2003	NUM
dti-1332	345	19	.	.	PUNCT
dti-1332	346	1	a	a	DET
dti-1332	346	2	novel	novel	ADJ
dti-1332	346	3	autosomal	autosomal	ADJ
dti-1332	346	4	dominant	dominant	ADJ
dti-1332	346	5	spinocerebellar	spinocerebellar	ADJ
dti-1332	346	6	ataxia	ataxia	NOUN
dti-1332	346	7	(	(	PUNCT
dti-1332	346	8	sca22	sca22	PROPN
dti-1332	346	9	)	)	PUNCT
dti-1332	346	10	linked	link	VERB
dti-1332	346	11	to	to	PART
dti-1332	346	12	chromosome	chromosome	VERB
dti-1332	346	13	1p21	1p21	NUM
dti-1332	346	14	-	-	PUNCT
dti-1332	346	15	q23	q23	NOUN
dti-1332	346	16	.	.	PUNCT
dti-1332	347	1	brain	brain	NOUN
dti-1332	347	2	,	,	PUNCT
dti-1332	347	3	126:1293–9	126:1293–9	NUM
dti-1332	347	4	.	.	PUNCT
dti-1332	348	1	chung	chung	PROPN
dti-1332	348	2	,	,	PUNCT
dti-1332	348	3	m.y	m.y	PROPN
dti-1332	348	4	.	.	PROPN
dti-1332	348	5	and	and	CCONJ
dti-1332	348	6	soong	soong	PROPN
dti-1332	348	7	,	,	PUNCT
dti-1332	348	8	b.w	b.w	PROPN
dti-1332	348	9	.	.	PROPN
dti-1332	348	10	2004	2004	NUM
dti-1332	348	11	.	.	PUNCT
dti-1332	349	1	reply	reply	VERB
dti-1332	349	2	to	to	ADP
dti-1332	349	3	:	:	PUNCT
dti-1332	349	4	sca-19	sca-19	PROPN
dti-1332	349	5	and	and	CCONJ
dti-1332	349	6	sca-22	sca-22	NOUN
dti-1332	349	7	:	:	PUNCT
dti-1332	349	8	evidence	evidence	NOUN
dti-1332	349	9	for	for	ADP
dti-1332	349	10	one	one	NUM
dti-1332	349	11	locus	locus	NOUN
dti-1332	349	12	with	with	ADP
dti-1332	349	13	a	a	DET
dti-1332	349	14	worldwide	worldwide	ADJ
dti-1332	349	15	distribution	distribution	NOUN
dti-1332	349	16	.	.	PUNCT
dti-1332	350	1	brain	brain	NOUN
dti-1332	350	2	,	,	PUNCT
dti-1332	350	3	127	127	NUM
dti-1332	350	4	:	:	PUNCT
dti-1332	350	5	e7	e7	PROPN
dti-1332	350	6	.	.	PUNCT
dti-1332	351	1	clinicaltrials.gov	clinicaltrials.gov	X
dti-1332	351	2	.	.	PROPN
dti-1332	351	3	accessed	access	VERB
dti-1332	351	4	4	4	NUM
dti-1332	351	5	march	march	NOUN
dti-1332	351	6	2008	2008	NUM
dti-1332	351	7	.	.	PUNCT
dti-1332	352	1	url	url	PROPN
dti-1332	352	2	:	:	PUNCT
dti-1332	352	3	http://www.clinicaltrials	http://www.clinicaltrial	NOUN
dti-1332	352	4	.	.	PUNCT
dti-1332	353	1	gov	gov	PROPN
dti-1332	353	2	/	/	SYM
dti-1332	353	3	ct2	ct2	PROPN
dti-1332	353	4	/	/	SYM
dti-1332	353	5	results?term	results?term	PROPN
dti-1332	353	6	=	=	NOUN
dti-1332	353	7	ataxia.html	ataxia.html	NOUN
dti-1332	353	8	.	.	PUNCT
dti-1332	354	1	coon	coon	PROPN
dti-1332	354	2	,	,	PUNCT
dti-1332	354	3	k.d	k.d	PROPN
dti-1332	354	4	.	.	PROPN
dti-1332	354	5	,	,	PUNCT
dti-1332	354	6	dunckley	dunckley	NOUN
dti-1332	354	7	,	,	PUNCT
dti-1332	354	8	t.	t.	PROPN
dti-1332	354	9	and	and	CCONJ
dti-1332	354	10	stephen	stephen	PROPN
dti-1332	354	11	,	,	PUNCT
dti-1332	354	12	d.a	d.a	PROPN
dti-1332	354	13	.	.	PROPN
dti-1332	354	14	2004	2004	NUM
dti-1332	354	15	.	.	PUNCT
dti-1332	355	1	biomarker	biomarker	NOUN
dti-1332	355	2	identifi	identifi	PROPN
dti-1332	355	3	cation	cation	NOUN
dti-1332	355	4	in	in	ADP
dti-1332	355	5	neurologic	neurologic	ADJ
dti-1332	355	6	diseases	disease	NOUN
dti-1332	355	7	:	:	PUNCT
dti-1332	355	8	improving	improve	VERB
dti-1332	355	9	diagnostics	diagnostic	NOUN
dti-1332	355	10	and	and	CCONJ
dti-1332	355	11	therapeutics	therapeutic	NOUN
dti-1332	355	12	.	.	PUNCT
dti-1332	356	1	expert	expert	PROPN
dti-1332	356	2	rev	rev	PROPN
dti-1332	356	3	.	.	PROPN
dti-1332	356	4	mol	mol	PROPN
dti-1332	356	5	.	.	PROPN
dti-1332	356	6	diagn	diagn	PROPN
dti-1332	356	7	.	.	PUNCT
dti-1332	356	8	,	,	PUNCT
dti-1332	357	1	4:361–75	4:361–75	PROPN
dti-1332	357	2	.	.	PUNCT
dti-1332	357	3	cummings	cummings	PROPN
dti-1332	357	4	,	,	PUNCT
dti-1332	357	5	c.j	c.j	PROPN
dti-1332	357	6	.	.	PROPN
dti-1332	357	7	and	and	CCONJ
dti-1332	357	8	zoghbi	zoghbi	PROPN
dti-1332	357	9	,	,	PUNCT
dti-1332	357	10	h.y	h.y	PROPN
dti-1332	357	11	.	.	PROPN
dti-1332	357	12	2000	2000	NUM
dti-1332	357	13	.	.	PUNCT
dti-1332	358	1	fourteen	fourteen	NUM
dti-1332	358	2	and	and	CCONJ
dti-1332	358	3	counting	counting	NOUN
dti-1332	358	4	:	:	PUNCT
dti-1332	358	5	unravelling	unravel	VERB
dti-1332	358	6	trinucleotide	trinucleotide	ADJ
dti-1332	358	7	repeat	repeat	NOUN
dti-1332	358	8	diseases	disease	NOUN
dti-1332	358	9	.	.	PUNCT
dti-1332	359	1	human	human	ADJ
dti-1332	359	2	molecular	molecular	ADJ
dti-1332	359	3	genetics	genetic	NOUN
dti-1332	359	4	,	,	PUNCT
dti-1332	359	5	9:909–16	9:909–16	PROPN
dti-1332	359	6	.	.	PUNCT
dti-1332	360	1	david	david	PROPN
dti-1332	360	2	,	,	PUNCT
dti-1332	360	3	c.	c.	PROPN
dti-1332	360	4	,	,	PUNCT
dti-1332	360	5	leggo	leggo	PROPN
dti-1332	360	6	,	,	PUNCT
dti-1332	360	7	r.a	r.a	PROPN
dti-1332	360	8	.	.	PROPN
dti-1332	360	9	,	,	PUNCT
dti-1332	360	10	coetzee	coetzee	PROPN
dti-1332	360	11	,	,	PUNCT
dti-1332	360	12	g.a	g.a	PROPN
dti-1332	360	13	.	.	PROPN
dti-1332	360	14	et	et	PROPN
dti-1332	360	15	al	al	PROPN
dti-1332	360	16	.	.	PROPN
dti-1332	360	17	1995	1995	NUM
dti-1332	360	18	.	.	PUNCT
dti-1332	361	1	sequence	sequence	NOUN
dti-1332	361	2	variation	variation	NOUN
dti-1332	361	3	and	and	CCONJ
dti-1332	361	4	size	size	NOUN
dti-1332	361	5	ranges	range	NOUN
dti-1332	361	6	of	of	ADP
dti-1332	361	7	cag	cag	PROPN
dti-1332	361	8	repeats	repeat	NOUN
dti-1332	361	9	in	in	ADP
dti-1332	361	10	the	the	DET
dti-1332	361	11	machado	machado	PROPN
dti-1332	361	12	-	-	PUNCT
dti-1332	361	13	joseph	joseph	PROPN
dti-1332	361	14	disease	disease	PROPN
dti-1332	361	15	,	,	PUNCT
dti-1332	361	16	spinocerebellar	spinocerebellar	ADJ
dti-1332	361	17	ataxia	ataxia	NOUN
dti-1332	361	18	type	type	NOUN
dti-1332	361	19	1	1	NUM
dti-1332	361	20	and	and	CCONJ
dti-1332	361	21	androgen	androgen	NOUN
dti-1332	361	22	receptor	receptor	NOUN
dti-1332	361	23	genes	gene	NOUN
dti-1332	361	24	.	.	PUNCT
dti-1332	362	1	hum	hum	ADJ
dti-1332	362	2	.	.	PUNCT
dti-1332	363	1	mol	mol	PROPN
dti-1332	363	2	.	.	PUNCT
dti-1332	363	3	genet	genet	PROPN
dti-1332	363	4	.	.	PUNCT
dti-1332	364	1	,	,	PUNCT
dti-1332	365	1	4:1585–90	4:1585–90	NUM
dti-1332	365	2	.	.	PUNCT
dti-1332	366	1	david	david	PROPN
dti-1332	366	2	,	,	PUNCT
dti-1332	366	3	g.	g.	PROPN
dti-1332	366	4	,	,	PUNCT
dti-1332	366	5	giunti	giunti	NOUN
dti-1332	366	6	,	,	PUNCT
dti-1332	366	7	p.	p.	NOUN
dti-1332	366	8	,	,	PUNCT
dti-1332	366	9	abbas	abbas	PROPN
dti-1332	366	10	,	,	PUNCT
dti-1332	366	11	n.	n.	PROPN
dti-1332	366	12	et	et	PROPN
dti-1332	366	13	al	al	PROPN
dti-1332	366	14	.	.	PROPN
dti-1332	366	15	1996	1996	NUM
dti-1332	366	16	.	.	PUNCT
dti-1332	367	1	the	the	DET
dti-1332	367	2	gene	gene	NOUN
dti-1332	367	3	forautosomal	forautosomal	ADJ
dti-1332	367	4	dominant	dominant	ADJ
dti-1332	367	5	cerebellar	cerebellar	ADJ
dti-1332	367	6	ataxia	ataxia	NOUN
dti-1332	367	7	typeii	typeii	NOUN
dti-1332	367	8	is	be	AUX
dti-1332	367	9	located	locate	VERB
dti-1332	367	10	in	in	ADP
dti-1332	367	11	a	a	DET
dti-1332	367	12	5	5	NUM
dti-1332	367	13	-	-	PUNCT
dti-1332	367	14	cm	cm	NOUN
dti-1332	367	15	region	region	NOUN
dti-1332	367	16	in	in	ADP
dti-1332	367	17	3p12	3p12	NUM
dti-1332	367	18	-	-	PUNCT
dti-1332	367	19	p13	p13	ADJ
dti-1332	367	20	:	:	PUNCT
dti-1332	367	21	genetic	genetic	ADJ
dti-1332	367	22	and	and	CCONJ
dti-1332	367	23	physical	physical	ADJ
dti-1332	367	24	mapping	mapping	NOUN
dti-1332	367	25	of	of	ADP
dti-1332	367	26	the	the	DET
dti-1332	367	27	sca7	sca7	NOUN
dti-1332	367	28	locus	locus	NOUN
dti-1332	367	29	.	.	PUNCT
dti-1332	368	1	am	be	AUX
dti-1332	368	2	.	.	PUNCT
dti-1332	369	1	j.	j.	PROPN
dti-1332	369	2	hum	hum	PROPN
dti-1332	369	3	.	.	PUNCT
dti-1332	370	1	genet	genet	PROPN
dti-1332	370	2	.	.	PUNCT
dti-1332	370	3	,	,	PUNCT
dti-1332	370	4	59:1328–36	59:1328–36	NUM
dti-1332	370	5	.	.	PUNCT
dti-1332	371	1	david	david	PROPN
dti-1332	371	2	,	,	PUNCT
dti-1332	371	3	g.	g.	PROPN
dti-1332	371	4	,	,	PUNCT
dti-1332	371	5	abbas	abbas	PROPN
dti-1332	371	6	,	,	PUNCT
dti-1332	371	7	n.	n.	NOUN
dti-1332	371	8	,	,	PUNCT
dti-1332	371	9	stevanin	stevanin	PROPN
dti-1332	371	10	,	,	PUNCT
dti-1332	371	11	g.	g.	PROPN
dti-1332	371	12	et	et	PROPN
dti-1332	371	13	al	al	PROPN
dti-1332	371	14	.	.	PROPN
dti-1332	371	15	1997	1997	NUM
dti-1332	371	16	.	.	PUNCT
dti-1332	372	1	cloning	cloning	NOUN
dti-1332	372	2	of	of	ADP
dti-1332	372	3	the	the	DET
dti-1332	372	4	sca7	sca7	NOUN
dti-1332	372	5	gene	gene	NOUN
dti-1332	372	6	reveals	reveal	VERB
dti-1332	372	7	a	a	DET
dti-1332	372	8	highly	highly	ADV
dti-1332	372	9	unstable	unstable	ADJ
dti-1332	372	10	cag	cag	PROPN
dti-1332	372	11	repeat	repeat	NOUN
dti-1332	372	12	expansion	expansion	NOUN
dti-1332	372	13	.	.	PUNCT
dti-1332	373	1	nat	nat	PROPN
dti-1332	373	2	.	.	PUNCT
dti-1332	374	1	genet	genet	PROPN
dti-1332	374	2	.	.	PUNCT
dti-1332	374	3	,	,	PUNCT
dti-1332	374	4	17:65–70	17:65–70	PROPN
dti-1332	374	5	.	.	PUNCT
dti-1332	375	1	davis	davis	PROPN
dti-1332	375	2	,	,	PUNCT
dti-1332	375	3	m.e	m.e	PROPN
dti-1332	375	4	.	.	PROPN
dti-1332	375	5	,	,	PUNCT
dti-1332	375	6	gonzalez	gonzalez	PROPN
dti-1332	375	7	,	,	PUNCT
dti-1332	375	8	h.	h.	PROPN
dti-1332	375	9	and	and	CCONJ
dti-1332	375	10	hwang	hwang	PROPN
dti-1332	375	11	,	,	PUNCT
dti-1332	375	12	s.j	s.j	PROPN
dti-1332	375	13	.	.	PROPN
dti-1332	375	14	1999	1999	NUM
dti-1332	375	15	.	.	PUNCT
dti-1332	376	1	new	new	ADJ
dti-1332	376	2	class	class	NOUN
dti-1332	376	3	of	of	ADP
dti-1332	376	4	polymers	polymer	NOUN
dti-1332	376	5	for	for	ADP
dti-1332	376	6	the	the	DET
dti-1332	376	7	delivery	delivery	NOUN
dti-1332	376	8	of	of	ADP
dti-1332	376	9	macromolecular	macromolecular	ADJ
dti-1332	376	10	therapeutics	therapeutic	NOUN
dti-1332	376	11	.	.	PUNCT
dti-1332	377	1	bioconjug	bioconjug	NOUN
dti-1332	377	2	.	.	PUNCT
dti-1332	378	1	chem	chem	PROPN
dti-1332	378	2	.	.	PUNCT
dti-1332	378	3	,	,	PUNCT
dti-1332	379	1	10:1068–74	10:1068–74	X
dti-1332	379	2	.	.	PUNCT
dti-1332	380	1	davis	davis	PROPN
dti-1332	380	2	,	,	PUNCT
dti-1332	380	3	m.e	m.e	PROPN
dti-1332	380	4	.	.	PROPN
dti-1332	380	5	,	,	PUNCT
dti-1332	380	6	pun	pun	ADJ
dti-1332	380	7	,	,	PUNCT
dti-1332	380	8	s.h	s.h	PROPN
dti-1332	380	9	.	.	PROPN
dti-1332	380	10	,	,	PUNCT
dti-1332	380	11	bellocq	bellocq	PROPN
dti-1332	380	12	,	,	PUNCT
dti-1332	380	13	n.c	n.c	PROPN
dti-1332	380	14	.	.	PROPN
dti-1332	380	15	et	et	PROPN
dti-1332	380	16	al	al	PROPN
dti-1332	380	17	.	.	PROPN
dti-1332	380	18	2004	2004	NUM
dti-1332	380	19	.	.	PUNCT
dti-1332	381	1	self	self	NOUN
dti-1332	381	2	-	-	PUNCT
dti-1332	381	3	assembling	assemble	VERB
dti-1332	381	4	nucleic	nucleic	ADJ
dti-1332	381	5	acid	acid	NOUN
dti-1332	381	6	delivery	delivery	NOUN
dti-1332	381	7	vehicles	vehicle	NOUN
dti-1332	381	8	via	via	ADP
dti-1332	381	9	linear	linear	ADJ
dti-1332	381	10	,	,	PUNCT
dti-1332	381	11	water	water	NOUN
dti-1332	381	12	-	-	PUNCT
dti-1332	381	13	soluble	soluble	ADJ
dti-1332	381	14	,	,	PUNCT
dti-1332	381	15	cyclodextrincontaining	cyclodextrincontaine	VERB
dti-1332	381	16	polymers	polymer	NOUN
dti-1332	381	17	.	.	PUNCT
dti-1332	382	1	curr	curr	AUX
dti-1332	382	2	.	.	PUNCT
dti-1332	382	3	med	med	PROPN
dti-1332	382	4	.	.	PROPN
dti-1332	382	5	chem	chem	PROPN
dti-1332	382	6	.	.	PUNCT
dti-1332	382	7	,	,	PUNCT
dti-1332	383	1	11:179–197	11:179–197	NUM
dti-1332	383	2	.	.	PUNCT
dti-1332	384	1	day	day	PROPN
dti-1332	384	2	,	,	PUNCT
dti-1332	384	3	j.w	j.w	PROPN
dti-1332	384	4	.	.	PROPN
dti-1332	384	5	,	,	PUNCT
dti-1332	384	6	schut	schut	PROPN
dti-1332	384	7	,	,	PUNCT
dti-1332	384	8	l.j	l.j	PROPN
dti-1332	384	9	.	.	PROPN
dti-1332	384	10	,	,	PUNCT
dti-1332	384	11	moseley	moseley	PROPN
dti-1332	384	12	,	,	PUNCT
dti-1332	384	13	m.l	m.l	PROPN
dti-1332	384	14	.	.	PROPN
dti-1332	384	15	et	et	PROPN
dti-1332	384	16	al	al	PROPN
dti-1332	384	17	.	.	PROPN
dti-1332	384	18	2000	2000	NUM
dti-1332	384	19	.	.	PUNCT
dti-1332	385	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	385	2	ataxia	ataxia	NOUN
dti-1332	385	3	type	type	NOUN
dti-1332	385	4	8	8	NUM
dti-1332	385	5	:	:	PUNCT
dti-1332	385	6	clinical	clinical	ADJ
dti-1332	385	7	features	feature	NOUN
dti-1332	385	8	in	in	ADP
dti-1332	385	9	a	a	DET
dti-1332	385	10	large	large	ADJ
dti-1332	385	11	family	family	NOUN
dti-1332	385	12	.	.	PUNCT
dti-1332	386	1	neurology	neurology	NOUN
dti-1332	386	2	,	,	PUNCT
dti-1332	386	3	55:649–57	55:649–57	NUM
dti-1332	386	4	.	.	PUNCT
dti-1332	387	1	de	de	PROPN
dti-1332	387	2	michele	michele	PROPN
dti-1332	387	3	,	,	PUNCT
dti-1332	387	4	g.	g.	PROPN
dti-1332	387	5	,	,	PUNCT
dti-1332	387	6	maltecca	maltecca	PROPN
dti-1332	387	7	,	,	PUNCT
dti-1332	387	8	f.	f.	PROPN
dti-1332	387	9	,	,	PUNCT
dti-1332	387	10	carella	carella	PROPN
dti-1332	387	11	,	,	PUNCT
dti-1332	387	12	m.	m.	NOUN
dti-1332	387	13	et	et	PROPN
dti-1332	387	14	al	al	PROPN
dti-1332	387	15	.	.	PROPN
dti-1332	387	16	2003	2003	NUM
dti-1332	387	17	.	.	PUNCT
dti-1332	388	1	dementia	dementia	NOUN
dti-1332	388	2	,	,	PUNCT
dti-1332	388	3	ataxia	ataxia	NOUN
dti-1332	388	4	,	,	PUNCT
dti-1332	388	5	extrapyramidal	extrapyramidal	NOUN
dti-1332	388	6	features	feature	NOUN
dti-1332	388	7	,	,	PUNCT
dti-1332	388	8	and	and	CCONJ
dti-1332	388	9	epilepsy	epilepsy	NOUN
dti-1332	388	10	:	:	PUNCT
dti-1332	388	11	phenotype	phenotype	NOUN
dti-1332	388	12	spectrum	spectrum	NOUN
dti-1332	388	13	in	in	ADP
dti-1332	388	14	two	two	NUM
dti-1332	388	15	italian	italian	ADJ
dti-1332	388	16	families	family	NOUN
dti-1332	388	17	with	with	ADP
dti-1332	388	18	spinocerebellar	spinocerebellar	ADJ
dti-1332	388	19	ataxia	ataxia	NOUN
dti-1332	388	20	type	type	NOUN
dti-1332	388	21	17	17	NUM
dti-1332	388	22	.	.	PUNCT
dti-1332	389	1	neurol	neurol	NOUN
dti-1332	389	2	.	.	PUNCT
dti-1332	390	1	sci	sci	PROPN
dti-1332	390	2	.	.	PROPN
dti-1332	390	3	,	,	PUNCT
dti-1332	390	4	24:166–7	24:166–7	NUM
dti-1332	390	5	.	.	PUNCT
dti-1332	391	1	devos	devos	PROPN
dti-1332	391	2	,	,	PUNCT
dti-1332	391	3	d.	d.	PROPN
dti-1332	391	4	,	,	PUNCT
dti-1332	391	5	schraen	schraen	NOUN
dti-1332	391	6	-	-	PUNCT
dti-1332	391	7	maschke	maschke	PROPN
dti-1332	391	8	,	,	PUNCT
dti-1332	391	9	s.	s.	PROPN
dti-1332	391	10	,	,	PUNCT
dti-1332	391	11	vuillaume	vuillaume	PROPN
dti-1332	391	12	,	,	PUNCT
dti-1332	391	13	i.	i.	PROPN
dti-1332	391	14	et	et	PROPN
dti-1332	391	15	al	al	PROPN
dti-1332	391	16	.	.	PROPN
dti-1332	391	17	2001	2001	NUM
dti-1332	391	18	.	.	PUNCT
dti-1332	392	1	clinical	clinical	ADJ
dti-1332	392	2	features	feature	NOUN
dti-1332	392	3	and	and	CCONJ
dti-1332	392	4	genetic	genetic	ADJ
dti-1332	392	5	analysis	analysis	NOUN
dti-1332	392	6	of	of	ADP
dti-1332	392	7	a	a	DET
dti-1332	392	8	new	new	ADJ
dti-1332	392	9	form	form	NOUN
dti-1332	392	10	of	of	ADP
dti-1332	392	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	392	12	ataxia	ataxia	NOUN
dti-1332	392	13	.	.	PUNCT
dti-1332	393	1	neurology	neurology	NOUN
dti-1332	393	2	,	,	PUNCT
dti-1332	393	3	56:234–8	56:234–8	NUM
dti-1332	393	4	.	.	PUNCT
dti-1332	394	1	ding	ding	PROPN
dti-1332	394	2	,	,	PUNCT
dti-1332	394	3	h.	h.	PROPN
dti-1332	394	4	,	,	PUNCT
dti-1332	394	5	schwarz	schwarz	PROPN
dti-1332	394	6	,	,	PUNCT
dti-1332	394	7	d.s	d.s	PROPN
dti-1332	394	8	.	.	PROPN
dti-1332	394	9	,	,	PUNCT
dti-1332	394	10	keene	keene	PROPN
dti-1332	394	11	,	,	PUNCT
dti-1332	394	12	a.	a.	PROPN
dti-1332	394	13	et	et	PROPN
dti-1332	394	14	al	al	PROPN
dti-1332	394	15	.	.	PROPN
dti-1332	394	16	2003	2003	NUM
dti-1332	394	17	.	.	PUNCT
dti-1332	395	1	selective	selective	ADJ
dti-1332	395	2	silencing	silencing	NOUN
dti-1332	395	3	by	by	ADP
dti-1332	395	4	rnai	rnai	PROPN
dti-1332	395	5	of	of	ADP
dti-1332	395	6	a	a	DET
dti-1332	395	7	dominant	dominant	ADJ
dti-1332	395	8	allele	allele	NOUN
dti-1332	395	9	that	that	PRON
dti-1332	395	10	causes	cause	VERB
dti-1332	395	11	amyotrophic	amyotrophic	ADJ
dti-1332	395	12	lateral	lateral	ADJ
dti-1332	395	13	sclerosis	sclerosis	NOUN
dti-1332	395	14	.	.	PUNCT
dti-1332	396	1	aging	age	VERB
dti-1332	396	2	cell	cell	NOUN
dti-1332	396	3	,	,	PUNCT
dti-1332	396	4	2:209–17	2:209–17	PROPN
dti-1332	396	5	.	.	PUNCT
dti-1332	396	6	di	di	PROPN
dti-1332	396	7	prospero	prospero	PROPN
dti-1332	396	8	,	,	PUNCT
dti-1332	396	9	n.a	n.a	PROPN
dti-1332	396	10	.	.	PROPN
dti-1332	396	11	,	,	PUNCT
dti-1332	396	12	baker	baker	PROPN
dti-1332	396	13	,	,	PUNCT
dti-1332	396	14	a.	a.	PROPN
dti-1332	396	15	,	,	PUNCT
dti-1332	396	16	jeffries	jeffrie	NOUN
dti-1332	396	17	,	,	PUNCT
dti-1332	396	18	n.	n.	PROPN
dti-1332	396	19	et	et	PROPN
dti-1332	396	20	al	al	PROPN
dti-1332	396	21	.	.	PROPN
dti-1332	396	22	2007	2007	NUM
dti-1332	396	23	.	.	PUNCT
dti-1332	397	1	neurological	neurological	ADJ
dti-1332	397	2	effects	effect	NOUN
dti-1332	397	3	of	of	ADP
dti-1332	397	4	high	high	ADJ
dti-1332	397	5	-	-	PUNCT
dti-1332	397	6	dose	dose	NOUN
dti-1332	397	7	idebenone	idebenone	NOUN
dti-1332	397	8	in	in	ADP
dti-1332	397	9	patients	patient	NOUN
dti-1332	397	10	with	with	ADP
dti-1332	397	11	friedreich	friedreich	PROPN
dti-1332	397	12	’s	’s	PART
dti-1332	397	13	ataxia	ataxia	NOUN
dti-1332	397	14	:	:	PUNCT
dti-1332	397	15	a	a	DET
dti-1332	397	16	randomised	randomised	ADJ
dti-1332	397	17	,	,	PUNCT
dti-1332	397	18	placebo	placebo	NOUN
dti-1332	397	19	-	-	PUNCT
dti-1332	397	20	controlled	control	VERB
dti-1332	397	21	trial	trial	NOUN
dti-1332	397	22	.	.	PUNCT
dti-1332	398	1	lancet	lancet	PROPN
dti-1332	398	2	neurol	neurol	PROPN
dti-1332	398	3	.	.	PUNCT
dti-1332	398	4	,	,	PUNCT
dti-1332	399	1	6:878–86	6:878–86	X
dti-1332	399	2	.	.	PUNCT
dti-1332	399	3	dong	dong	PROPN
dti-1332	399	4	,	,	PUNCT
dti-1332	399	5	y.	y.	PROPN
dti-1332	399	6	and	and	CCONJ
dti-1332	399	7	feng	feng	PROPN
dti-1332	399	8	,	,	PUNCT
dti-1332	399	9	s.s	s.s	PROPN
dti-1332	399	10	.	.	PROPN
dti-1332	399	11	2004	2004	NUM
dti-1332	399	12	.	.	PUNCT
dti-1332	400	1	methoxy	methoxy	ADJ
dti-1332	400	2	poly(ethylene	poly(ethylene	PROPN
dti-1332	400	3	glycol)-poly(lactide	glycol)-poly(lactide	NOUN
dti-1332	400	4	)	)	PUNCT
dti-1332	400	5	(	(	PUNCT
dti-1332	400	6	mpeg	mpeg	NOUN
dti-1332	400	7	-	-	PUNCT
dti-1332	400	8	pla	pla	NOUN
dti-1332	400	9	)	)	PUNCT
dti-1332	400	10	nanoparticles	nanoparticle	NOUN
dti-1332	400	11	for	for	ADP
dti-1332	400	12	controlled	control	VERB
dti-1332	400	13	delivery	delivery	NOUN
dti-1332	400	14	of	of	ADP
dti-1332	400	15	anticancer	anticancer	NOUN
dti-1332	400	16	drugs	drug	NOUN
dti-1332	400	17	.	.	PUNCT
dti-1332	401	1	biomaterials	biomaterial	NOUN
dti-1332	401	2	,	,	PUNCT
dti-1332	401	3	25:2843–9	25:2843–9	NUM
dti-1332	401	4	.	.	PUNCT
dti-1332	402	1	dorn	dorn	PROPN
dti-1332	402	2	,	,	PUNCT
dti-1332	402	3	g.	g.	PROPN
dti-1332	402	4	,	,	PUNCT
dti-1332	402	5	patel	patel	PROPN
dti-1332	402	6	,	,	PUNCT
dti-1332	402	7	s.	s.	PROPN
dti-1332	402	8	,	,	PUNCT
dti-1332	402	9	wotherspoon	wotherspoon	ADV
dti-1332	402	10	,	,	PUNCT
dti-1332	402	11	g.	g.	PROPN
dti-1332	402	12	et	et	PROPN
dti-1332	402	13	al	al	PROPN
dti-1332	402	14	.	.	PROPN
dti-1332	402	15	2004	2004	NUM
dti-1332	402	16	.	.	PUNCT
dti-1332	403	1	sirna	sirna	PROPN
dti-1332	403	2	relieves	relieve	VERB
dti-1332	403	3	chronic	chronic	ADJ
dti-1332	403	4	neuropathic	neuropathic	ADJ
dti-1332	403	5	pain	pain	NOUN
dti-1332	403	6	.	.	PUNCT
dti-1332	404	1	nucleic	nucleic	ADJ
dti-1332	404	2	acids	acid	NOUN
dti-1332	404	3	research	research	NOUN
dti-1332	404	4	,	,	PUNCT
dti-1332	404	5	32	32	NUM
dti-1332	404	6	:	:	PUNCT
dti-1332	404	7	e49	e49	PROPN
dti-1332	404	8	.	.	PUNCT
dti-1332	405	1	duenas	duena	NOUN
dti-1332	405	2	,	,	PUNCT
dti-1332	405	3	a.m.	a.m.	ADV
dti-1332	405	4	,	,	PUNCT
dti-1332	405	5	goold	goold	PROPN
dti-1332	405	6	,	,	PUNCT
dti-1332	405	7	r.	r.	PROPN
dti-1332	405	8	and	and	CCONJ
dti-1332	405	9	giunti	giunti	PROPN
dti-1332	405	10	,	,	PUNCT
dti-1332	405	11	p.	p.	NOUN
dti-1332	405	12	2006	2006	NUM
dti-1332	405	13	.	.	PUNCT
dti-1332	406	1	molecular	molecular	ADJ
dti-1332	406	2	pathogenesis	pathogenesis	NOUN
dti-1332	406	3	of	of	ADP
dti-1332	406	4	spinocerebellar	spinocerebellar	ADJ
dti-1332	406	5	ataxias	ataxia	NOUN
dti-1332	406	6	.	.	PUNCT
dti-1332	407	1	brain	brain	NOUN
dti-1332	407	2	,	,	PUNCT
dti-1332	407	3	129:1357–70	129:1357–70	PROPN
dti-1332	407	4	.	.	PUNCT
dti-1332	408	1	durr	durr	PROPN
dti-1332	408	2	,	,	PUNCT
dti-1332	408	3	a.	a.	NOUN
dti-1332	408	4	,	,	PUNCT
dti-1332	408	5	stevanin	stevanin	NOUN
dti-1332	408	6	,	,	PUNCT
dti-1332	408	7	g.	g.	PROPN
dti-1332	408	8	,	,	PUNCT
dti-1332	408	9	cancel	cancel	VERB
dti-1332	408	10	,	,	PUNCT
dti-1332	408	11	g.	g.	PROPN
dti-1332	408	12	et	et	PROPN
dti-1332	408	13	al	al	PROPN
dti-1332	408	14	.	.	PROPN
dti-1332	408	15	1996	1996	NUM
dti-1332	408	16	.	.	PUNCT
dti-1332	409	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	409	2	ataxia	ataxia	NOUN
dti-1332	409	3	3	3	NUM
dti-1332	409	4	and	and	CCONJ
dti-1332	409	5	machado	machado	PROPN
dti-1332	409	6	-	-	PUNCT
dti-1332	409	7	joseph	joseph	PROPN
dti-1332	409	8	disease	disease	PROPN
dti-1332	409	9	:	:	PUNCT
dti-1332	409	10	clinical	clinical	ADJ
dti-1332	409	11	,	,	PUNCT
dti-1332	409	12	molecular	molecular	ADJ
dti-1332	409	13	,	,	PUNCT
dti-1332	409	14	and	and	CCONJ
dti-1332	409	15	neuropathological	neuropathological	ADJ
dti-1332	409	16	features	feature	NOUN
dti-1332	409	17	.	.	PUNCT
dti-1332	410	1	ann	ann	PROPN
dti-1332	410	2	.	.	PUNCT
dti-1332	411	1	neurol	neurol	PROPN
dti-1332	411	2	.	.	PUNCT
dti-1332	411	3	,	,	PUNCT
dti-1332	411	4	39:490–9	39:490–9	NUM
dti-1332	411	5	.	.	PUNCT
dti-1332	412	1	elbashir	elbashir	NOUN
dti-1332	412	2	,	,	PUNCT
dti-1332	412	3	s.m	s.m	PROPN
dti-1332	412	4	.	.	PROPN
dti-1332	412	5	,	,	PUNCT
dti-1332	412	6	harborth	harborth	PROPN
dti-1332	412	7	,	,	PUNCT
dti-1332	412	8	j.	j.	PROPN
dti-1332	412	9	,	,	PUNCT
dti-1332	412	10	lendeckel	lendeckel	PROPN
dti-1332	412	11	,	,	PUNCT
dti-1332	412	12	w.	w.	PROPN
dti-1332	412	13	et	et	PROPN
dti-1332	412	14	al	al	PROPN
dti-1332	412	15	.	.	PROPN
dti-1332	412	16	2001	2001	NUM
dti-1332	412	17	.	.	PUNCT
dti-1332	413	1	duplexes	duplex	NOUN
dti-1332	413	2	of	of	ADP
dti-1332	413	3	21	21	NUM
dti-1332	413	4	nucleotide	nucleotide	NOUN
dti-1332	413	5	rnas	rnas	PROPN
dti-1332	413	6	mediate	mediate	PROPN
dti-1332	413	7	rna	rna	NOUN
dti-1332	413	8	interference	interference	NOUN
dti-1332	413	9	in	in	ADP
dti-1332	413	10	mammalian	mammalian	ADJ
dti-1332	413	11	cell	cell	NOUN
dti-1332	413	12	culture	culture	NOUN
dti-1332	413	13	.	.	PUNCT
dti-1332	414	1	nature	nature	NOUN
dti-1332	414	2	,	,	PUNCT
dti-1332	414	3	411:494–8	411:494–8	NOUN
dti-1332	414	4	.	.	PUNCT
dti-1332	415	1	elbashir	elbashir	NOUN
dti-1332	415	2	,	,	PUNCT
dti-1332	415	3	s.m	s.m	PROPN
dti-1332	415	4	.	.	PROPN
dti-1332	415	5	,	,	PUNCT
dti-1332	415	6	lendeckel	lendeckel	PROPN
dti-1332	415	7	,	,	PUNCT
dti-1332	415	8	w.	w.	PROPN
dti-1332	415	9	and	and	CCONJ
dti-1332	415	10	tuschl	tuschl	NOUN
dti-1332	415	11	,	,	PUNCT
dti-1332	415	12	t.	t.	PROPN
dti-1332	415	13	2001	2001	NUM
dti-1332	415	14	.	.	PUNCT
dti-1332	416	1	rna	rna	NOUN
dti-1332	416	2	interference	interference	NOUN
dti-1332	416	3	is	be	AUX
dti-1332	416	4	mediated	mediate	VERB
dti-1332	416	5	by	by	ADP
dti-1332	416	6	21–22	21–22	NUM
dti-1332	416	7	nucleotide	nucleotide	NOUN
dti-1332	416	8	rnas	rna	NOUN
dti-1332	416	9	.	.	PUNCT
dti-1332	417	1	genes	gene	NOUN
dti-1332	417	2	and	and	CCONJ
dti-1332	417	3	dev	dev	PROPN
dti-1332	417	4	.	.	PROPN
dti-1332	417	5	,	,	PUNCT
dti-1332	417	6	15:188–200	15:188–200	NUM
dti-1332	417	7	.	.	PUNCT
dti-1332	418	1	everett	everett	PROPN
dti-1332	418	2	,	,	PUNCT
dti-1332	418	3	c.m	c.m	PROPN
dti-1332	418	4	.	.	PROPN
dti-1332	418	5	and	and	CCONJ
dti-1332	418	6	wood	wood	PROPN
dti-1332	418	7	,	,	PUNCT
dti-1332	418	8	n.w	n.w	PROPN
dti-1332	418	9	.	.	PROPN
dti-1332	418	10	2004	2004	NUM
dti-1332	418	11	.	.	PUNCT
dti-1332	419	1	trinucleotide	trinucleotide	ADJ
dti-1332	419	2	repeats	repeat	NOUN
dti-1332	419	3	and	and	CCONJ
dti-1332	419	4	neurodegenerative	neurodegenerative	ADJ
dti-1332	419	5	disease	disease	NOUN
dti-1332	419	6	.	.	PUNCT
dti-1332	420	1	brain	brain	NOUN
dti-1332	420	2	,	,	PUNCT
dti-1332	420	3	127:2385–405	127:2385–405	NUM
dti-1332	420	4	.	.	PUNCT
dti-1332	421	1	fire	fire	NOUN
dti-1332	421	2	,	,	PUNCT
dti-1332	421	3	a.	a.	PROPN
dti-1332	421	4	,	,	PUNCT
dti-1332	421	5	xu	xu	PROPN
dti-1332	421	6	,	,	PUNCT
dti-1332	421	7	s.	s.	PROPN
dti-1332	421	8	,	,	PUNCT
dti-1332	421	9	montgomery	montgomery	PROPN
dti-1332	421	10	,	,	PUNCT
dti-1332	421	11	m.k	m.k	PROPN
dti-1332	421	12	.	.	PROPN
dti-1332	421	13	et	et	PROPN
dti-1332	421	14	al	al	PROPN
dti-1332	421	15	.	.	PROPN
dti-1332	421	16	1998	1998	NUM
dti-1332	421	17	.	.	PUNCT
dti-1332	422	1	potent	potent	NOUN
dti-1332	422	2	and	and	CCONJ
dti-1332	422	3	specifi	specifi	PROPN
dti-1332	422	4	c	c	PROPN
dti-1332	422	5	genetic	genetic	ADJ
dti-1332	422	6	interference	interference	NOUN
dti-1332	422	7	by	by	ADP
dti-1332	422	8	double	double	ADJ
dti-1332	422	9	stranded	strand	VERB
dti-1332	422	10	rna	rna	NOUN
dti-1332	422	11	in	in	ADP
dti-1332	422	12	caenorhabditis	caenorhabditis	PROPN
dti-1332	422	13	elegans	elegans	PROPN
dti-1332	422	14	.	.	PUNCT
dti-1332	423	1	nature	nature	NOUN
dti-1332	423	2	,	,	PUNCT
dti-1332	423	3	391:806–11	391:806–11	PROPN
dti-1332	423	4	.	.	PUNCT
dti-1332	424	1	fischer	fischer	PROPN
dti-1332	424	2	,	,	PUNCT
dti-1332	424	3	d.	d.	PROPN
dti-1332	424	4	,	,	PUNCT
dti-1332	424	5	li	li	PROPN
dti-1332	424	6	,	,	PUNCT
dti-1332	424	7	y.	y.	PROPN
dti-1332	424	8	,	,	PUNCT
dti-1332	424	9	ahlemeyer	ahlemeyer	PROPN
dti-1332	424	10	,	,	PUNCT
dti-1332	424	11	b.	b.	PROPN
dti-1332	424	12	et	et	PROPN
dti-1332	424	13	al	al	PROPN
dti-1332	424	14	.	.	PROPN
dti-1332	424	15	2003	2003	NUM
dti-1332	424	16	.	.	PUNCT
dti-1332	425	1	in	in	ADP
dti-1332	425	2	vitro	vitro	X
dti-1332	425	3	cytotoxicity	cytotoxicity	NOUN
dti-1332	425	4	testing	testing	NOUN
dti-1332	425	5	of	of	ADP
dti-1332	425	6	polycations	polycation	NOUN
dti-1332	425	7	:	:	PUNCT
dti-1332	425	8	infl	infl	PROPN
dti-1332	425	9	uence	uence	NOUN
dti-1332	425	10	of	of	ADP
dti-1332	425	11	polymer	polymer	NOUN
dti-1332	425	12	structure	structure	NOUN
dti-1332	425	13	on	on	ADP
dti-1332	425	14	cell	cell	NOUN
dti-1332	425	15	viability	viability	NOUN
dti-1332	425	16	and	and	CCONJ
dti-1332	425	17	hemolysis	hemolysis	NOUN
dti-1332	425	18	.	.	PUNCT
dti-1332	426	1	biomaterials	biomaterial	NOUN
dti-1332	426	2	,	,	PUNCT
dti-1332	426	3	24:1121–31	24:1121–31	NOUN
dti-1332	426	4	.	.	PUNCT
dti-1332	427	1	flanigan	flanigan	PROPN
dti-1332	427	2	,	,	PUNCT
dti-1332	427	3	k.	k.	PROPN
dti-1332	427	4	,	,	PUNCT
dti-1332	427	5	gardner	gardner	PROPN
dti-1332	427	6	,	,	PUNCT
dti-1332	427	7	k.	k.	PROPN
dti-1332	427	8	,	,	PUNCT
dti-1332	427	9	alderson	alderson	PROPN
dti-1332	427	10	,	,	PUNCT
dti-1332	427	11	k.	k.	PROPN
dti-1332	427	12	et	et	PROPN
dti-1332	427	13	al	al	PROPN
dti-1332	427	14	.	.	PROPN
dti-1332	427	15	1996	1996	NUM
dti-1332	427	16	.	.	PUNCT
dti-1332	428	1	autosomal	autosomal	ADJ
dti-1332	428	2	dominant	dominant	ADJ
dti-1332	428	3	spinocerebellar	spinocerebellar	ADJ
dti-1332	428	4	ataxia	ataxia	NOUN
dti-1332	428	5	with	with	ADP
dti-1332	428	6	sensory	sensory	ADJ
dti-1332	428	7	axonal	axonal	ADJ
dti-1332	428	8	neuropathy	neuropathy	ADJ
dti-1332	428	9	(	(	PUNCT
dti-1332	428	10	sca4	sca4	PROPN
dti-1332	428	11	):	):	PUNCT
dti-1332	428	12	clinical	clinical	ADJ
dti-1332	428	13	description	description	NOUN
dti-1332	428	14	and	and	CCONJ
dti-1332	428	15	genetic	genetic	ADJ
dti-1332	428	16	localization	localization	NOUN
dti-1332	428	17	to	to	PART
dti-1332	428	18	chromosome	chromosome	VERB
dti-1332	428	19	16q22.1	16q22.1	NUM
dti-1332	428	20	.	.	PUNCT
dti-1332	428	21	am	be	AUX
dti-1332	428	22	.	.	PUNCT
dti-1332	429	1	j.	j.	PROPN
dti-1332	429	2	hum	hum	PROPN
dti-1332	429	3	.	.	PUNCT
dti-1332	430	1	genet	genet	PROPN
dti-1332	430	2	.	.	PUNCT
dti-1332	430	3	,	,	PUNCT
dti-1332	430	4	59:392–9	59:392–9	NUM
dti-1332	430	5	.	.	NOUN
dti-1332	430	6	forte	forte	PROPN
dti-1332	430	7	,	,	PUNCT
dti-1332	430	8	a.	a.	NOUN
dti-1332	430	9	,	,	PUNCT
dti-1332	430	10	cipollaro	cipollaro	NOUN
dti-1332	430	11	,	,	PUNCT
dti-1332	430	12	m.	m.	NOUN
dti-1332	430	13	,	,	PUNCT
dti-1332	430	14	cascino	cascino	PROPN
dti-1332	430	15	,	,	PUNCT
dti-1332	430	16	a.	a.	PROPN
dti-1332	430	17	et	et	PROPN
dti-1332	430	18	al	al	PROPN
dti-1332	430	19	.	.	PROPN
dti-1332	430	20	2005	2005	NUM
dti-1332	430	21	.	.	PUNCT
dti-1332	431	1	small	small	ADJ
dti-1332	431	2	interfering	interfere	VERB
dti-1332	431	3	rnas	rna	NOUN
dti-1332	431	4	and	and	CCONJ
dti-1332	431	5	antisense	antisense	NOUN
dti-1332	431	6	oligonucleotides	oligonucleotide	NOUN
dti-1332	431	7	for	for	ADP
dti-1332	431	8	treatment	treatment	NOUN
dti-1332	431	9	of	of	ADP
dti-1332	431	10	neurological	neurological	ADJ
dti-1332	431	11	diseases	disease	NOUN
dti-1332	431	12	.	.	PUNCT
dti-1332	432	1	current	current	ADJ
dti-1332	432	2	drug	drug	NOUN
dti-1332	432	3	targets	target	NOUN
dti-1332	432	4	,	,	PUNCT
dti-1332	432	5	6:21–9	6:21–9	NOUN
dti-1332	432	6	.	.	PUNCT
dti-1332	433	1	fujigasaki	fujigasaki	PROPN
dti-1332	433	2	,	,	PUNCT
dti-1332	433	3	h.	h.	PROPN
dti-1332	433	4	,	,	PUNCT
dti-1332	433	5	martin	martin	PROPN
dti-1332	433	6	,	,	PUNCT
dti-1332	433	7	j.-j	j.-j	PROPN
dti-1332	433	8	.	.	PROPN
dti-1332	433	9	,	,	PUNCT
dti-1332	433	10	de	de	X
dti-1332	433	11	deyn	deyn	NOUN
dti-1332	433	12	,	,	PUNCT
dti-1332	433	13	p.p	p.p	PROPN
dti-1332	433	14	.	.	PROPN
dti-1332	433	15	et	et	PROPN
dti-1332	433	16	al	al	PROPN
dti-1332	433	17	.	.	PROPN
dti-1332	433	18	2001	2001	NUM
dti-1332	433	19	.	.	PUNCT
dti-1332	434	1	cag	cag	PROPN
dti-1332	434	2	repeat	repeat	VERB
dti-1332	434	3	expansion	expansion	NOUN
dti-1332	434	4	in	in	ADP
dti-1332	434	5	the	the	DET
dti-1332	434	6	tata	tata	PROPN
dti-1332	434	7	box	box	NOUN
dti-1332	434	8	-	-	PUNCT
dti-1332	434	9	binding	bind	VERB
dti-1332	434	10	protein	protein	NOUN
dti-1332	434	11	gene	gene	NOUN
dti-1332	434	12	causes	cause	VERB
dti-1332	434	13	autosomal	autosomal	ADJ
dti-1332	434	14	dominant	dominant	ADJ
dti-1332	434	15	cerebellar	cerebellar	ADJ
dti-1332	434	16	ataxia	ataxia	NOUN
dti-1332	434	17	.	.	PUNCT
dti-1332	435	1	brain	brain	NOUN
dti-1332	435	2	,	,	PUNCT
dti-1332	435	3	124:1939–47	124:1939–47	PROPN
dti-1332	435	4	.	.	PUNCT
dti-1332	435	5	gan	gan	PROPN
dti-1332	435	6	,	,	PUNCT
dti-1332	435	7	l.	l.	PROPN
dti-1332	435	8	,	,	PUNCT
dti-1332	435	9	anton	anton	PROPN
dti-1332	435	10	,	,	PUNCT
dti-1332	435	11	k.e	k.e	PROPN
dti-1332	435	12	.	.	PROPN
dti-1332	435	13	,	,	PUNCT
dti-1332	435	14	masterson	masterson	PROPN
dti-1332	435	15	,	,	PUNCT
dti-1332	435	16	b.a	b.a	PROPN
dti-1332	435	17	.	.	PROPN
dti-1332	435	18	et	et	PROPN
dti-1332	435	19	al	al	PROPN
dti-1332	435	20	.	.	PROPN
dti-1332	435	21	2002	2002	NUM
dti-1332	435	22	.	.	PUNCT
dti-1332	436	1	specifi	specifi	PROPN
dti-1332	436	2	c	c	PROPN
dti-1332	436	3	interference	interference	NOUN
dti-1332	436	4	with	with	ADP
dti-1332	436	5	gene	gene	NOUN
dti-1332	436	6	expression	expression	NOUN
dti-1332	436	7	and	and	CCONJ
dti-1332	436	8	gene	gene	NOUN
dti-1332	436	9	function	function	NOUN
dti-1332	436	10	mediated	mediate	VERB
dti-1332	436	11	by	by	ADP
dti-1332	436	12	long	long	ADJ
dti-1332	436	13	dsrna	dsrna	NOUN
dti-1332	436	14	in	in	ADP
dti-1332	436	15	neural	neural	ADJ
dti-1332	436	16	cells	cell	NOUN
dti-1332	436	17	.	.	PUNCT
dti-1332	437	1	j.	j.	PROPN
dti-1332	437	2	neurosci	neurosci	PROPN
dti-1332	437	3	.	.	PUNCT
dti-1332	438	1	meth	meth	PROPN
dti-1332	438	2	.	.	PUNCT
dti-1332	438	3	,	,	PUNCT
dti-1332	438	4	121:151–7	121:151–7	NUM
dti-1332	438	5	.	.	NOUN
dti-1332	438	6	115	115	NUM
dti-1332	438	7	recent	recent	ADJ
dti-1332	438	8	advancements	advancement	NOUN
dti-1332	438	9	in	in	ADP
dti-1332	438	10	targeted	target	VERB
dti-1332	438	11	delivery	delivery	NOUN
dti-1332	438	12	of	of	ADP
dti-1332	438	13	therapeutic	therapeutic	ADJ
dti-1332	438	14	molecules	molecule	NOUN
dti-1332	438	15	drug	drug	NOUN
dti-1332	438	16	target	target	NOUN
dti-1332	438	17	insights	insight	NOUN
dti-1332	438	18	2008:3	2008:3	NUM
dti-1332	438	19	gazulla	gazulla	NOUN
dti-1332	438	20	,	,	PUNCT
dti-1332	438	21	j.	j.	PROPN
dti-1332	438	22	,	,	PUNCT
dti-1332	438	23	errea	errea	PROPN
dti-1332	438	24	,	,	PUNCT
dti-1332	438	25	j.m	j.m	PROPN
dti-1332	438	26	.	.	PROPN
dti-1332	438	27	,	,	PUNCT
dti-1332	438	28	benavente	benavente	NOUN
dti-1332	438	29	,	,	PUNCT
dti-1332	438	30	i.	i.	PROPN
dti-1332	438	31	et	et	PROPN
dti-1332	438	32	al	al	PROPN
dti-1332	438	33	.	.	PROPN
dti-1332	438	34	2004	2004	NUM
dti-1332	438	35	.	.	PUNCT
dti-1332	439	1	treatment	treatment	NOUN
dti-1332	439	2	of	of	ADP
dti-1332	439	3	ataxia	ataxia	NOUN
dti-1332	439	4	in	in	ADP
dti-1332	439	5	cortical	cortical	ADJ
dti-1332	439	6	cerebellar	cerebellar	ADJ
dti-1332	439	7	atrophy	atrophy	NOUN
dti-1332	439	8	with	with	ADP
dti-1332	439	9	the	the	DET
dti-1332	439	10	gabaergic	gabaergic	ADJ
dti-1332	439	11	drug	drug	NOUN
dti-1332	439	12	gabapentine	gabapentine	NOUN
dti-1332	439	13	.	.	PUNCT
dti-1332	440	1	a	a	DET
dti-1332	440	2	preliminary	preliminary	ADJ
dti-1332	440	3	study	study	NOUN
dti-1332	440	4	.	.	PUNCT
dti-1332	441	1	eur	eur	PROPN
dti-1332	441	2	.	.	PUNCT
dti-1332	442	1	neurol	neurol	PROPN
dti-1332	442	2	.	.	PUNCT
dti-1332	442	3	,	,	PUNCT
dti-1332	442	4	52:7–11	52:7–11	NUM
dti-1332	442	5	.	.	PUNCT
dti-1332	443	1	gonzalez	gonzalez	PROPN
dti-1332	443	2	-	-	PUNCT
dti-1332	443	3	alegre	alegre	PROPN
dti-1332	443	4	,	,	PUNCT
dti-1332	443	5	p.	p.	NOUN
dti-1332	443	6	,	,	PUNCT
dti-1332	443	7	miller	miller	PROPN
dti-1332	443	8	,	,	PUNCT
dti-1332	443	9	v.m	v.m	PROPN
dti-1332	443	10	.	.	PROPN
dti-1332	443	11	,	,	PUNCT
dti-1332	443	12	davidson	davidson	PROPN
dti-1332	443	13	,	,	PUNCT
dti-1332	443	14	b.l	b.l	PROPN
dti-1332	443	15	.	.	PROPN
dti-1332	443	16	et	et	PROPN
dti-1332	443	17	al	al	PROPN
dti-1332	443	18	.	.	PROPN
dti-1332	443	19	2003	2003	NUM
dti-1332	443	20	.	.	PUNCT
dti-1332	444	1	toward	toward	ADP
dti-1332	444	2	therapy	therapy	NOUN
dti-1332	444	3	for	for	ADP
dti-1332	444	4	dyt1	dyt1	NOUN
dti-1332	444	5	dystonia	dystonia	NOUN
dti-1332	444	6	:	:	PUNCT
dti-1332	444	7	allele	allele	PROPN
dti-1332	444	8	-	-	PUNCT
dti-1332	444	9	specifi	specifi	PROPN
dti-1332	444	10	c	c	PROPN
dti-1332	444	11	silencing	silencing	NOUN
dti-1332	444	12	of	of	ADP
dti-1332	444	13	mutant	mutant	ADJ
dti-1332	444	14	torsin	torsin	PROPN
dti-1332	444	15	a.	a.	PROPN
dti-1332	444	16	ann	ann	PROPN
dti-1332	444	17	.	.	PUNCT
dti-1332	445	1	neurol	neurol	PROPN
dti-1332	445	2	.	.	PUNCT
dti-1332	445	3	,	,	PUNCT
dti-1332	445	4	53:781–7	53:781–7	NUM
dti-1332	445	5	.	.	PUNCT
dti-1332	446	1	grewal	grewal	PROPN
dti-1332	446	2	,	,	PUNCT
dti-1332	446	3	r.p	r.p	PROPN
dti-1332	446	4	.	.	PROPN
dti-1332	446	5	,	,	PUNCT
dti-1332	446	6	achari	achari	PROPN
dti-1332	446	7	,	,	PUNCT
dti-1332	446	8	m.	m.	NOUN
dti-1332	446	9	,	,	PUNCT
dti-1332	446	10	matsuura	matsuura	PROPN
dti-1332	446	11	,	,	PUNCT
dti-1332	446	12	t.	t.	PROPN
dti-1332	446	13	et	et	PROPN
dti-1332	446	14	al	al	PROPN
dti-1332	446	15	.	.	PROPN
dti-1332	446	16	2002	2002	NUM
dti-1332	446	17	.	.	PUNCT
dti-1332	447	1	clinical	clinical	ADJ
dti-1332	447	2	features	feature	NOUN
dti-1332	447	3	and	and	CCONJ
dti-1332	447	4	attct	attct	NOUN
dti-1332	447	5	repeat	repeat	NOUN
dti-1332	447	6	expansion	expansion	NOUN
dti-1332	447	7	in	in	ADP
dti-1332	447	8	spinocerebellar	spinocerebellar	ADJ
dti-1332	447	9	ataxia	ataxia	NOUN
dti-1332	447	10	type	type	NOUN
dti-1332	447	11	10	10	NUM
dti-1332	447	12	.	.	PUNCT
dti-1332	447	13	arch	arch	NOUN
dti-1332	447	14	.	.	PUNCT
dti-1332	448	1	neurol	neurol	NOUN
dti-1332	448	2	.	.	PUNCT
dti-1332	448	3	,	,	PUNCT
dti-1332	448	4	59:1285–90	59:1285–90	NUM
dti-1332	448	5	.	.	PUNCT
dti-1332	449	1	grimm	grimm	NOUN
dti-1332	449	2	,	,	PUNCT
dti-1332	449	3	d.	d.	PROPN
dti-1332	449	4	and	and	CCONJ
dti-1332	449	5	kleinschmidt	kleinschmidt	PROPN
dti-1332	449	6	,	,	PUNCT
dti-1332	449	7	j.a	j.a	PROPN
dti-1332	449	8	.	.	PROPN
dti-1332	449	9	1999	1999	NUM
dti-1332	449	10	.	.	PUNCT
dti-1332	450	1	progress	progress	NOUN
dti-1332	450	2	in	in	ADP
dti-1332	450	3	adeno	adeno	NOUN
dti-1332	450	4	-	-	PUNCT
dti-1332	450	5	associated	associate	VERB
dti-1332	450	6	virus	virus	NOUN
dti-1332	450	7	type	type	NOUN
dti-1332	450	8	2	2	NUM
dti-1332	450	9	vector	vector	NOUN
dti-1332	450	10	production	production	NOUN
dti-1332	450	11	:	:	PUNCT
dti-1332	450	12	promises	promise	NOUN
dti-1332	450	13	and	and	CCONJ
dti-1332	450	14	prospects	prospect	NOUN
dti-1332	450	15	for	for	ADP
dti-1332	450	16	clinical	clinical	ADJ
dti-1332	450	17	use	use	NOUN
dti-1332	450	18	.	.	PUNCT
dti-1332	451	1	hum	hum	ADJ
dti-1332	451	2	.	.	PUNCT
dti-1332	452	1	gene	gene	NOUN
dti-1332	452	2	ther	ther	ADV
dti-1332	452	3	.	.	PUNCT
dti-1332	453	1	,	,	PUNCT
dti-1332	453	2	10:2445–50	10:2445–50	NOUN
dti-1332	453	3	.	.	PUNCT
dti-1332	454	1	gulyaev	gulyaev	NOUN
dti-1332	454	2	,	,	PUNCT
dti-1332	454	3	a.e	a.e	PROPN
dti-1332	454	4	.	.	PROPN
dti-1332	454	5	,	,	PUNCT
dti-1332	454	6	gelperina	gelperina	PROPN
dti-1332	454	7	,	,	PUNCT
dti-1332	454	8	s.e	s.e	PROPN
dti-1332	454	9	.	.	PROPN
dti-1332	454	10	,	,	PUNCT
dti-1332	454	11	skidan	skidan	PROPN
dti-1332	454	12	,	,	PUNCT
dti-1332	454	13	i.n	i.n	PROPN
dti-1332	454	14	.	.	PROPN
dti-1332	454	15	et	et	PROPN
dti-1332	454	16	al	al	PROPN
dti-1332	454	17	.	.	PROPN
dti-1332	454	18	1999	1999	NUM
dti-1332	454	19	.	.	PUNCT
dti-1332	455	1	signifi	signifi	NOUN
dti-1332	455	2	ca	can	AUX
dti-1332	455	3	nt	not	PART
dti-1332	455	4	transport	transport	VERB
dti-1332	455	5	of	of	ADP
dti-1332	455	6	doxorubicin	doxorubicin	PROPN
dti-1332	455	7	into	into	ADP
dti-1332	455	8	the	the	DET
dti-1332	455	9	brain	brain	NOUN
dti-1332	455	10	with	with	ADP
dti-1332	455	11	polysorbate	polysorbate	NOUN
dti-1332	455	12	80	80	NUM
dti-1332	455	13	-	-	PUNCT
dti-1332	455	14	coated	coat	VERB
dti-1332	455	15	nanoparticles	nanoparticle	NOUN
dti-1332	455	16	.	.	PUNCT
dti-1332	456	1	pharmaceutical	pharmaceutical	ADJ
dti-1332	456	2	research	research	NOUN
dti-1332	456	3	,	,	PUNCT
dti-1332	456	4	16:1564–9	16:1564–9	NUM
dti-1332	456	5	.	.	PUNCT
dti-1332	457	1	haberhausena	haberhausena	PROPN
dti-1332	457	2	,	,	PUNCT
dti-1332	457	3	g.	g.	PROPN
dti-1332	457	4	,	,	PUNCT
dti-1332	457	5	damianb	damianb	PROPN
dti-1332	457	6	,	,	PUNCT
dti-1332	457	7	m.s	m.s	PROPN
dti-1332	457	8	.	.	PROPN
dti-1332	457	9	,	,	PUNCT
dti-1332	457	10	lewekeb	lewekeb	VERB
dti-1332	457	11	,	,	PUNCT
dti-1332	457	12	f.	f.	PROPN
dti-1332	457	13	et	et	PROPN
dti-1332	457	14	al	al	PROPN
dti-1332	457	15	.	.	PROPN
dti-1332	457	16	1995	1995	NUM
dti-1332	457	17	.	.	PUNCT
dti-1332	458	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	458	2	ataxia	ataxia	NOUN
dti-1332	458	3	,	,	PUNCT
dti-1332	458	4	type	type	NOUN
dti-1332	458	5	3	3	NUM
dti-1332	458	6	(	(	PUNCT
dti-1332	458	7	sca3	sca3	PROPN
dti-1332	458	8	)	)	PUNCT
dti-1332	458	9	is	be	AUX
dti-1332	458	10	genetically	genetically	ADV
dti-1332	458	11	identical	identical	ADJ
dti-1332	458	12	to	to	ADP
dti-1332	458	13	machado	machado	PROPN
dti-1332	458	14	-	-	PUNCT
dti-1332	458	15	joseph	joseph	PROPN
dti-1332	458	16	disease	disease	NOUN
dti-1332	458	17	(	(	PUNCT
dti-1332	458	18	mjd	mjd	PROPN
dti-1332	458	19	)	)	PUNCT
dti-1332	458	20	.	.	PUNCT
dti-1332	459	1	j.	j.	PROPN
dti-1332	459	2	neurol	neurol	PROPN
dti-1332	459	3	.	.	PUNCT
dti-1332	460	1	sci	sci	PROPN
dti-1332	460	2	.	.	PROPN
dti-1332	460	3	,	,	PUNCT
dti-1332	460	4	132:71–5	132:71–5	NUM
dti-1332	460	5	.	.	PUNCT
dti-1332	461	1	hamilton	hamilton	PROPN
dti-1332	461	2	,	,	PUNCT
dti-1332	461	3	a.j	a.j	PROPN
dti-1332	461	4	.	.	PROPN
dti-1332	461	5	and	and	CCONJ
dti-1332	461	6	baulcombe	baulcombe	PROPN
dti-1332	461	7	,	,	PUNCT
dti-1332	461	8	d.c	d.c	PROPN
dti-1332	461	9	.	.	PROPN
dti-1332	461	10	1999	1999	NUM
dti-1332	461	11	.	.	PUNCT
dti-1332	462	1	a	a	DET
dti-1332	462	2	species	species	NOUN
dti-1332	462	3	of	of	ADP
dti-1332	462	4	small	small	ADJ
dti-1332	462	5	antisense	antisense	NOUN
dti-1332	462	6	rna	rna	NOUN
dti-1332	462	7	in	in	ADP
dti-1332	462	8	post	post	NOUN
dti-1332	462	9	transcriptional	transcriptional	ADJ
dti-1332	462	10	gene	gene	NOUN
dti-1332	462	11	silencing	silence	VERB
dti-1332	462	12	in	in	ADP
dti-1332	462	13	plants	plant	NOUN
dti-1332	462	14	.	.	PUNCT
dti-1332	463	1	science	science	NOUN
dti-1332	463	2	,	,	PUNCT
dti-1332	463	3	286:950–2	286:950–2	NUM
dti-1332	463	4	.	.	PUNCT
dti-1332	464	1	harper	harper	PROPN
dti-1332	464	2	,	,	PUNCT
dti-1332	464	3	s.q	s.q	PROPN
dti-1332	464	4	.	.	PROPN
dti-1332	464	5	,	,	PUNCT
dti-1332	464	6	staber	staber	PROPN
dti-1332	464	7	,	,	PUNCT
dti-1332	464	8	p.d	p.d	PROPN
dti-1332	464	9	.	.	PROPN
dti-1332	464	10	,	,	PUNCT
dti-1332	464	11	he	he	PRON
dti-1332	464	12	,	,	PUNCT
dti-1332	464	13	x.	x.	PROPN
dti-1332	464	14	et	et	PROPN
dti-1332	464	15	al	al	PROPN
dti-1332	464	16	.	.	PROPN
dti-1332	464	17	2005	2005	NUM
dti-1332	464	18	.	.	PUNCT
dti-1332	465	1	rna	rna	NOUN
dti-1332	465	2	interference	interference	NOUN
dti-1332	465	3	improves	improve	VERB
dti-1332	465	4	motor	motor	NOUN
dti-1332	465	5	and	and	CCONJ
dti-1332	465	6	neuropathological	neuropathological	ADJ
dti-1332	465	7	abnormalities	abnormality	NOUN
dti-1332	465	8	in	in	ADP
dti-1332	465	9	a	a	DET
dti-1332	465	10	huntington	huntington	PROPN
dti-1332	465	11	’s	’s	PART
dti-1332	465	12	disease	disease	PROPN
dti-1332	465	13	mouse	mouse	PROPN
dti-1332	465	14	model	model	NOUN
dti-1332	465	15	.	.	PUNCT
dti-1332	466	1	proc	proc	PROPN
dti-1332	466	2	.	.	PUNCT
dti-1332	467	1	natl	natl	PROPN
dti-1332	467	2	.	.	PUNCT
dti-1332	468	1	aca	aca	PROPN
dti-1332	468	2	.	.	PUNCT
dti-1332	469	1	sci	sci	PROPN
dti-1332	469	2	.	.	PUNCT
dti-1332	469	3	u.s.a	u.s.a	PROPN
dti-1332	469	4	.	.	PROPN
dti-1332	469	5	,	,	PUNCT
dti-1332	469	6	102:5820–5	102:5820–5	X
dti-1332	469	7	.	.	PUNCT
dti-1332	470	1	hellenbroich	hellenbroich	PROPN
dti-1332	470	2	,	,	PUNCT
dti-1332	470	3	y.	y.	PROPN
dti-1332	470	4	,	,	PUNCT
dti-1332	470	5	bubel	bubel	PROPN
dti-1332	470	6	,	,	PUNCT
dti-1332	470	7	s.	s.	PROPN
dti-1332	470	8	,	,	PUNCT
dti-1332	470	9	pawlack	pawlack	VERB
dti-1332	470	10	,	,	PUNCT
dti-1332	470	11	h.	h.	PROPN
dti-1332	470	12	et	et	PROPN
dti-1332	470	13	al	al	PROPN
dti-1332	470	14	.	.	PROPN
dti-1332	470	15	2003	2003	NUM
dti-1332	470	16	.	.	PUNCT
dti-1332	471	1	refi	refi	PROPN
dti-1332	471	2	nement	nement	ADJ
dti-1332	471	3	of	of	ADP
dti-1332	471	4	the	the	DET
dti-1332	471	5	spinocerebellar	spinocerebellar	ADJ
dti-1332	471	6	ataxia	ataxia	NOUN
dti-1332	471	7	type	type	NOUN
dti-1332	471	8	4	4	NUM
dti-1332	471	9	locus	locus	NOUN
dti-1332	471	10	in	in	ADP
dti-1332	471	11	a	a	DET
dti-1332	471	12	large	large	ADJ
dti-1332	471	13	german	german	ADJ
dti-1332	471	14	family	family	NOUN
dti-1332	471	15	and	and	CCONJ
dti-1332	471	16	exclusion	exclusion	NOUN
dti-1332	471	17	of	of	ADP
dti-1332	471	18	cag	cag	PROPN
dti-1332	471	19	repeat	repeat	NOUN
dti-1332	471	20	expansions	expansion	NOUN
dti-1332	471	21	in	in	ADP
dti-1332	471	22	this	this	DET
dti-1332	471	23	region	region	NOUN
dti-1332	471	24	.	.	PUNCT
dti-1332	472	1	journal	journal	PROPN
dti-1332	472	2	of	of	ADP
dti-1332	472	3	neurology	neurology	NOUN
dti-1332	472	4	,	,	PUNCT
dti-1332	472	5	250:668–71	250:668–71	PROPN
dti-1332	472	6	.	.	PUNCT
dti-1332	473	1	herman	herman	PROPN
dti-1332	473	2	-	-	PUNCT
dti-1332	473	3	bert	bert	PROPN
dti-1332	473	4	,	,	PUNCT
dti-1332	473	5	a.	a.	NOUN
dti-1332	473	6	,	,	PUNCT
dti-1332	473	7	stevanin	stevanin	NOUN
dti-1332	473	8	,	,	PUNCT
dti-1332	473	9	g.	g.	NOUN
dti-1332	473	10	,	,	PUNCT
dti-1332	473	11	netter	netter	PROPN
dti-1332	473	12	,	,	PUNCT
dti-1332	473	13	j.	j.	PROPN
dti-1332	473	14	et	et	PROPN
dti-1332	473	15	al	al	PROPN
dti-1332	473	16	.	.	PROPN
dti-1332	473	17	2000	2000	NUM
dti-1332	473	18	.	.	PUNCT
dti-1332	474	1	mapping	mapping	NOUN
dti-1332	474	2	of	of	ADP
dti-1332	474	3	spinocerebellar	spinocerebellar	ADJ
dti-1332	474	4	ataxia	ataxia	NOUN
dti-1332	474	5	13	13	NUM
dti-1332	474	6	to	to	PART
dti-1332	474	7	chromosome	chromosome	VERB
dti-1332	474	8	19q13.3	19q13.3	NUM
dti-1332	474	9	-	-	PUNCT
dti-1332	474	10	q13.4	q13.4	NOUN
dti-1332	474	11	in	in	ADP
dti-1332	474	12	a	a	DET
dti-1332	474	13	family	family	NOUN
dti-1332	474	14	with	with	ADP
dti-1332	474	15	autosomal	autosomal	ADJ
dti-1332	474	16	dominant	dominant	ADJ
dti-1332	474	17	cerebellar	cerebellar	ADJ
dti-1332	474	18	ataxia	ataxia	NOUN
dti-1332	474	19	and	and	CCONJ
dti-1332	474	20	mental	mental	ADJ
dti-1332	474	21	retardation	retardation	NOUN
dti-1332	474	22	.	.	PUNCT
dti-1332	475	1	am	be	AUX
dti-1332	475	2	.	.	PUNCT
dti-1332	476	1	j.	j.	PROPN
dti-1332	476	2	hum	hum	PROPN
dti-1332	476	3	.	.	PUNCT
dti-1332	477	1	genet	genet	PROPN
dti-1332	477	2	.	.	PUNCT
dti-1332	477	3	,	,	PUNCT
dti-1332	477	4	67:229–35	67:229–35	PROPN
dti-1332	477	5	.	.	PUNCT
dti-1332	478	1	heydenreich	heydenreich	PROPN
dti-1332	478	2	,	,	PUNCT
dti-1332	478	3	a.v	a.v	PROPN
dti-1332	478	4	.	.	PROPN
dti-1332	478	5	,	,	PUNCT
dti-1332	478	6	westmeier	westmeier	NOUN
dti-1332	478	7	,	,	PUNCT
dti-1332	478	8	r.	r.	PROPN
dti-1332	478	9	,	,	PUNCT
dti-1332	478	10	pedersen	pedersen	PROPN
dti-1332	478	11	,	,	PUNCT
dti-1332	478	12	n.	n.	NOUN
dti-1332	478	13	et	et	PROPN
dti-1332	478	14	al	al	PROPN
dti-1332	478	15	.	.	PROPN
dti-1332	478	16	2003	2003	NUM
dti-1332	478	17	.	.	PUNCT
dti-1332	479	1	preparation	preparation	NOUN
dti-1332	479	2	and	and	CCONJ
dti-1332	479	3	purifi	purifi	ADJ
dti-1332	479	4	cation	cation	NOUN
dti-1332	479	5	of	of	ADP
dti-1332	479	6	cationic	cationic	ADJ
dti-1332	479	7	solid	solid	ADJ
dti-1332	479	8	lipid	lipid	NOUN
dti-1332	479	9	nanospheres	nanosphere	NOUN
dti-1332	479	10	—	—	PUNCT
dti-1332	479	11	effects	effect	NOUN
dti-1332	479	12	on	on	ADP
dti-1332	479	13	particle	particle	NOUN
dti-1332	479	14	size	size	NOUN
dti-1332	479	15	,	,	PUNCT
dti-1332	479	16	physical	physical	ADJ
dti-1332	479	17	stability	stability	NOUN
dti-1332	479	18	and	and	CCONJ
dti-1332	479	19	cell	cell	NOUN
dti-1332	479	20	toxicity	toxicity	NOUN
dti-1332	479	21	.	.	PUNCT
dti-1332	480	1	int	int	NOUN
dti-1332	480	2	.	.	PUNCT
dti-1332	481	1	j.	j.	PROPN
dti-1332	481	2	pharm	pharm	PROPN
dti-1332	481	3	,	,	PUNCT
dti-1332	481	4	254:83–7	254:83–7	NUM
dti-1332	481	5	.	.	PUNCT
dti-1332	481	6	hutvagner	hutvagner	PROPN
dti-1332	481	7	,	,	PUNCT
dti-1332	481	8	g.	g.	PROPN
dti-1332	481	9	and	and	CCONJ
dti-1332	481	10	zamore	zamore	PROPN
dti-1332	481	11	,	,	PUNCT
dti-1332	481	12	p.d	p.d	PROPN
dti-1332	481	13	.	.	PROPN
dti-1332	481	14	2002	2002	NUM
dti-1332	481	15	.	.	PUNCT
dti-1332	482	1	rnai	rnai	PROPN
dti-1332	482	2	:	:	PUNCT
dti-1332	482	3	nature	nature	NOUN
dti-1332	482	4	abhors	abhor	VERB
dti-1332	482	5	a	a	DET
dti-1332	482	6	double	double	ADJ
dti-1332	482	7	-	-	PUNCT
dti-1332	482	8	strand	strand	NOUN
dti-1332	482	9	.	.	PUNCT
dti-1332	483	1	curr	curr	PROPN
dti-1332	483	2	.	.	PUNCT
dti-1332	484	1	opin	opin	NOUN
dti-1332	484	2	.	.	PUNCT
dti-1332	485	1	genetics	genetic	NOUN
dti-1332	485	2	and	and	CCONJ
dti-1332	485	3	development	development	NOUN
dti-1332	485	4	,	,	PUNCT
dti-1332	485	5	12:225–32	12:225–32	NOUN
dti-1332	485	6	.	.	PUNCT
dti-1332	486	1	holmberg	holmberg	PROPN
dti-1332	486	2	,	,	PUNCT
dti-1332	486	3	c.i	c.i	PROPN
dti-1332	486	4	.	.	PROPN
dti-1332	486	5	,	,	PUNCT
dti-1332	486	6	staniszewski	staniszewski	NOUN
dti-1332	486	7	,	,	PUNCT
dti-1332	486	8	k.i	k.i	PROPN
dti-1332	486	9	.	.	PROPN
dti-1332	486	10	,	,	PUNCT
dti-1332	486	11	mensah	mensah	PROPN
dti-1332	486	12	,	,	PUNCT
dti-1332	486	13	k.n	k.n	PROPN
dti-1332	486	14	.	.	PROPN
dti-1332	486	15	et	et	PROPN
dti-1332	486	16	al	al	PROPN
dti-1332	486	17	.	.	PROPN
dti-1332	486	18	2004	2004	NUM
dti-1332	486	19	.	.	PUNCT
dti-1332	487	1	ineffi	ineffi	PROPN
dti-1332	487	2	cient	cient	VERB
dti-1332	487	3	degradation	degradation	NOUN
dti-1332	487	4	of	of	ADP
dti-1332	487	5	truncated	truncate	VERB
dti-1332	487	6	polyglutamine	polyglutamine	NOUN
dti-1332	487	7	proteins	protein	NOUN
dti-1332	487	8	by	by	ADP
dti-1332	487	9	the	the	DET
dti-1332	487	10	proteasome	proteasome	NOUN
dti-1332	487	11	.	.	PUNCT
dti-1332	488	1	the	the	DET
dti-1332	488	2	embo	embo	PROPN
dti-1332	488	3	journal	journal	NOUN
dti-1332	488	4	,	,	PUNCT
dti-1332	488	5	23:4307–18	23:4307–18	NUM
dti-1332	488	6	.	.	PUNCT
dti-1332	488	7	holmes	holmes	PROPN
dti-1332	488	8	,	,	PUNCT
dti-1332	488	9	s.e	s.e	PROPN
dti-1332	488	10	.	.	PROPN
dti-1332	488	11	,	,	PUNCT
dti-1332	488	12	hearn	hearn	PROPN
dti-1332	488	13	,	,	PUNCT
dti-1332	488	14	e.o	e.o	PROPN
dti-1332	488	15	.	.	PROPN
dti-1332	488	16	,	,	PUNCT
dti-1332	488	17	mcinnis	mcinnis	PROPN
dti-1332	488	18	,	,	PUNCT
dti-1332	488	19	m.g	m.g	PROPN
dti-1332	488	20	.	.	PROPN
dti-1332	488	21	et	et	PROPN
dti-1332	488	22	al	al	PROPN
dti-1332	488	23	.	.	PROPN
dti-1332	488	24	1999	1999	NUM
dti-1332	488	25	.	.	PUNCT
dti-1332	489	1	expansion	expansion	NOUN
dti-1332	489	2	of	of	ADP
dti-1332	489	3	a	a	DET
dti-1332	489	4	novel	novel	NOUN
dti-1332	489	5	cag	cag	PROPN
dti-1332	489	6	trinucleotide	trinucleotide	INTJ
dti-1332	489	7	repeat	repeat	VERB
dti-1332	489	8	in	in	ADP
dti-1332	489	9	the	the	DET
dti-1332	489	10	5	5	NUM
dti-1332	489	11	’	'	PUNCT
dti-1332	489	12	region	region	NOUN
dti-1332	489	13	of	of	ADP
dti-1332	489	14	ppp2r2b	ppp2r2b	PROPN
dti-1332	489	15	is	be	AUX
dti-1332	489	16	associated	associate	VERB
dti-1332	489	17	with	with	ADP
dti-1332	489	18	sca12	sca12	PROPN
dti-1332	489	19	.	.	PUNCT
dti-1332	490	1	nature	nature	NOUN
dti-1332	490	2	genetics	genetic	NOUN
dti-1332	490	3	,	,	PUNCT
dti-1332	490	4	23:391–2	23:391–2	NUM
dti-1332	490	5	.	.	PUNCT
dti-1332	491	1	houlden	houlden	PROPN
dti-1332	491	2	,	,	PUNCT
dti-1332	491	3	h.	h.	PROPN
dti-1332	491	4	,	,	PUNCT
dti-1332	491	5	johnson	johnson	PROPN
dti-1332	491	6	,	,	PUNCT
dti-1332	491	7	j.	j.	PROPN
dti-1332	491	8	,	,	PUNCT
dti-1332	491	9	gardner	gardner	PROPN
dti-1332	491	10	-	-	PUNCT
dti-1332	491	11	thorpe	thorpe	PROPN
dti-1332	491	12	,	,	PUNCT
dti-1332	491	13	c.	c.	PROPN
dti-1332	491	14	et	et	PROPN
dti-1332	491	15	al	al	PROPN
dti-1332	491	16	.	.	PROPN
dti-1332	491	17	2007	2007	NUM
dti-1332	491	18	.	.	PUNCT
dti-1332	492	1	mutations	mutation	NOUN
dti-1332	492	2	in	in	ADP
dti-1332	492	3	ttbk2	ttbk2	PROPN
dti-1332	492	4	,	,	PUNCT
dti-1332	492	5	encoding	encode	VERB
dti-1332	492	6	a	a	DET
dti-1332	492	7	kinase	kinase	NOUN
dti-1332	492	8	implicated	implicate	VERB
dti-1332	492	9	in	in	ADP
dti-1332	492	10	tau	tau	PROPN
dti-1332	492	11	phosphorylation	phosphorylation	NOUN
dti-1332	492	12	,	,	PUNCT
dti-1332	492	13	segregate	segregate	VERB
dti-1332	492	14	with	with	ADP
dti-1332	492	15	spinocerebellar	spinocerebellar	ADJ
dti-1332	492	16	ataxia	ataxia	NOUN
dti-1332	492	17	type	type	NOUN
dti-1332	492	18	11	11	NUM
dti-1332	492	19	.	.	PUNCT
dti-1332	493	1	nat	nat	PROPN
dti-1332	493	2	.	.	PUNCT
dti-1332	494	1	genet	genet	PROPN
dti-1332	494	2	.	.	PUNCT
dti-1332	494	3	,	,	PUNCT
dti-1332	495	1	39:1434–6	39:1434–6	X
dti-1332	495	2	.	.	PUNCT
dti-1332	496	1	ikeda	ikeda	PROPN
dti-1332	496	2	,	,	PUNCT
dti-1332	496	3	y.	y.	PROPN
dti-1332	496	4	,	,	PUNCT
dti-1332	496	5	dick	dick	PROPN
dti-1332	496	6	,	,	PUNCT
dti-1332	496	7	k.a	k.a	PROPN
dti-1332	496	8	.	.	PROPN
dti-1332	496	9	,	,	PUNCT
dti-1332	496	10	weatherspoon	weatherspoon	PROPN
dti-1332	496	11	,	,	PUNCT
dti-1332	496	12	m.r	m.r	PROPN
dti-1332	496	13	.	.	PROPN
dti-1332	496	14	et	et	PROPN
dti-1332	496	15	al	al	PROPN
dti-1332	496	16	.	.	PROPN
dti-1332	496	17	2006	2006	NUM
dti-1332	496	18	.	.	PUNCT
dti-1332	497	1	spectrin	spectrin	NOUN
dti-1332	497	2	mutations	mutation	NOUN
dti-1332	497	3	cause	cause	VERB
dti-1332	497	4	spinocerebellar	spinocerebellar	ADJ
dti-1332	497	5	ataxia	ataxia	NOUN
dti-1332	497	6	type	type	NOUN
dti-1332	497	7	5	5	NUM
dti-1332	497	8	.	.	PUNCT
dti-1332	498	1	nat	nat	PROPN
dti-1332	498	2	.	.	PUNCT
dti-1332	499	1	genet	genet	PROPN
dti-1332	499	2	.	.	PUNCT
dti-1332	499	3	,	,	PUNCT
dti-1332	499	4	38:184–90	38:184–90	PROPN
dti-1332	499	5	.	.	PUNCT
dti-1332	500	1	ito	ito	PROPN
dti-1332	500	2	,	,	PUNCT
dti-1332	500	3	h.	h.	PROPN
dti-1332	500	4	,	,	PUNCT
dti-1332	500	5	kawakami	kawakami	PROPN
dti-1332	500	6	,	,	PUNCT
dti-1332	500	7	h.	h.	PROPN
dti-1332	500	8	,	,	PUNCT
dti-1332	500	9	wate	wate	PROPN
dti-1332	500	10	,	,	PUNCT
dti-1332	500	11	r.	r.	PROPN
dti-1332	500	12	et	et	PROPN
dti-1332	500	13	al	al	PROPN
dti-1332	500	14	.	.	PROPN
dti-1332	500	15	2006	2006	NUM
dti-1332	500	16	.	.	PUNCT
dti-1332	501	1	clinicopathologic	clinicopathologic	ADJ
dti-1332	501	2	investigation	investigation	NOUN
dti-1332	501	3	of	of	ADP
dti-1332	501	4	a	a	DET
dti-1332	501	5	family	family	NOUN
dti-1332	501	6	with	with	ADP
dti-1332	501	7	expanded	expand	VERB
dti-1332	501	8	sca8	sca8	NOUN
dti-1332	501	9	cta	cta	NOUN
dti-1332	501	10	/	/	SYM
dti-1332	501	11	ctg	ctg	NOUN
dti-1332	501	12	repeats	repeat	NOUN
dti-1332	501	13	.	.	PUNCT
dti-1332	502	1	neurology	neurology	NOUN
dti-1332	502	2	,	,	PUNCT
dti-1332	502	3	67:1479–81	67:1479–81	NUM
dti-1332	502	4	.	.	PUNCT
dti-1332	503	1	ito	ito	PROPN
dti-1332	503	2	,	,	PUNCT
dti-1332	503	3	m.	m.	NOUN
dti-1332	503	4	,	,	PUNCT
dti-1332	503	5	yamamoto	yamamoto	PROPN
dti-1332	503	6	,	,	PUNCT
dti-1332	503	7	s.	s.	PROPN
dti-1332	503	8	,	,	PUNCT
dti-1332	503	9	nimura	nimura	ADV
dti-1332	503	10	,	,	PUNCT
dti-1332	503	11	k.	k.	PROPN
dti-1332	503	12	et	et	PROPN
dti-1332	503	13	al	al	PROPN
dti-1332	503	14	.	.	PROPN
dti-1332	503	15	2005	2005	NUM
dti-1332	503	16	.	.	PUNCT
dti-1332	504	1	rad	rad	PROPN
dti-1332	504	2	51	51	NUM
dti-1332	504	3	sirna	sirna	PROPN
dti-1332	504	4	delivered	deliver	VERB
dti-1332	504	5	by	by	ADP
dti-1332	504	6	hvj	hvj	PROPN
dti-1332	504	7	.	.	PUNCT
dti-1332	505	1	envelope	envelope	NOUN
dti-1332	505	2	vector	vector	NOUN
dti-1332	505	3	enhances	enhance	VERB
dti-1332	505	4	the	the	DET
dti-1332	505	5	anti	anti	ADJ
dti-1332	505	6	cancer	cancer	NOUN
dti-1332	505	7	effect	effect	NOUN
dti-1332	505	8	of	of	ADP
dti-1332	505	9	cisplastin	cisplastin	PROPN
dti-1332	505	10	.	.	PUNCT
dti-1332	506	1	j.	j.	PROPN
dti-1332	506	2	gene	gene	PROPN
dti-1332	506	3	med	me	VERB
dti-1332	506	4	.	.	PROPN
dti-1332	506	5	,	,	PUNCT
dti-1332	506	6	7:1044–52	7:1044–52	PROPN
dti-1332	506	7	.	.	PUNCT
dti-1332	507	1	jonge	jonge	PROPN
dti-1332	507	2	,	,	PUNCT
dti-1332	507	3	j.	j.	PROPN
dti-1332	507	4	,	,	PUNCT
dti-1332	507	5	holtrop	holtrop	NOUN
dti-1332	507	6	,	,	PUNCT
dti-1332	507	7	m.	m.	NOUN
dti-1332	507	8	,	,	PUNCT
dti-1332	507	9	wilschut	wilschut	PROPN
dti-1332	507	10	,	,	PUNCT
dti-1332	507	11	j.	j.	PROPN
dti-1332	507	12	et	et	PROPN
dti-1332	507	13	al	al	PROPN
dti-1332	507	14	.	.	PROPN
dti-1332	507	15	2006	2006	NUM
dti-1332	507	16	.	.	PUNCT
dti-1332	508	1	reconstituted	reconstitute	VERB
dti-1332	508	2	infl	infl	PROPN
dti-1332	508	3	uenza	uenza	PROPN
dti-1332	508	4	virus	virus	NOUN
dti-1332	508	5	envelopes	envelope	NOUN
dti-1332	508	6	as	as	ADP
dti-1332	508	7	an	an	DET
dti-1332	508	8	effi	effi	PROPN
dti-1332	508	9	cient	cient	NOUN
dti-1332	508	10	carrier	carrier	NOUN
dti-1332	508	11	system	system	NOUN
dti-1332	508	12	for	for	ADP
dti-1332	508	13	cellular	cellular	ADJ
dti-1332	508	14	delivery	delivery	NOUN
dti-1332	508	15	of	of	ADP
dti-1332	508	16	small	small	ADJ
dti-1332	508	17	interfering	interfere	VERB
dti-1332	508	18	rnas	rna	NOUN
dti-1332	508	19	.	.	PUNCT
dti-1332	509	1	gene	gene	NOUN
dti-1332	509	2	ther	ther	ADV
dti-1332	509	3	.	.	PUNCT
dti-1332	509	4	,	,	PUNCT
dti-1332	510	1	13:400–11	13:400–11	PROPN
dti-1332	510	2	.	.	PUNCT
dti-1332	511	1	juvonen	juvonen	PROPN
dti-1332	511	2	,	,	PUNCT
dti-1332	511	3	v.	v.	PROPN
dti-1332	511	4	,	,	PUNCT
dti-1332	511	5	hietala	hietala	NOUN
dti-1332	511	6	,	,	PUNCT
dti-1332	511	7	m.	m.	NOUN
dti-1332	511	8	,	,	PUNCT
dti-1332	511	9	paivarinta	paivarinta	NOUN
dti-1332	511	10	,	,	PUNCT
dti-1332	511	11	m.	m.	NOUN
dti-1332	511	12	et	et	PROPN
dti-1332	511	13	al	al	PROPN
dti-1332	511	14	.	.	PROPN
dti-1332	511	15	2000	2000	NUM
dti-1332	511	16	.	.	PUNCT
dti-1332	512	1	clinical	clinical	ADJ
dti-1332	512	2	and	and	CCONJ
dti-1332	512	3	genetic	genetic	ADJ
dti-1332	512	4	fi	fi	NOUN
dti-1332	512	5	ndings	nding	NOUN
dti-1332	512	6	in	in	ADP
dti-1332	512	7	finnish	finnish	ADJ
dti-1332	512	8	ataxia	ataxia	NOUN
dti-1332	512	9	patients	patient	NOUN
dti-1332	512	10	with	with	ADP
dti-1332	512	11	the	the	DET
dti-1332	512	12	spinocerebellar	spinocerebellar	ADJ
dti-1332	512	13	ataxia	ataxia	NOUN
dti-1332	512	14	8	8	NUM
dti-1332	512	15	repeat	repeat	NOUN
dti-1332	512	16	expansion	expansion	NOUN
dti-1332	512	17	.	.	PUNCT
dti-1332	513	1	ann	ann	PROPN
dti-1332	513	2	.	.	PUNCT
dti-1332	514	1	neurol	neurol	PROPN
dti-1332	514	2	.	.	PUNCT
dti-1332	514	3	,	,	PUNCT
dti-1332	514	4	48:354–61	48:354–61	PROPN
dti-1332	514	5	.	.	PUNCT
dti-1332	515	1	kimchi	kimchi	PROPN
dti-1332	515	2	-	-	PUNCT
dti-1332	515	3	sarfaty	sarfaty	PROPN
dti-1332	515	4	,	,	PUNCT
dti-1332	515	5	c.	c.	PROPN
dti-1332	515	6	,	,	PUNCT
dti-1332	515	7	brittain	brittain	PROPN
dti-1332	515	8	,	,	PUNCT
dti-1332	515	9	s.	s.	PROPN
dti-1332	515	10	,	,	PUNCT
dti-1332	515	11	garfi	garfi	ADJ
dti-1332	515	12	eld	eld	NOUN
dti-1332	515	13	,	,	PUNCT
dti-1332	515	14	s.	s.	PROPN
dti-1332	515	15	et	et	PROPN
dti-1332	515	16	al	al	PROPN
dti-1332	515	17	.	.	PROPN
dti-1332	515	18	2005	2005	NUM
dti-1332	515	19	.	.	PUNCT
dti-1332	516	1	effi	effi	PROPN
dti-1332	516	2	cient	cient	PROPN
dti-1332	516	3	delivery	delivery	NOUN
dti-1332	516	4	of	of	ADP
dti-1332	516	5	rna	rna	NOUN
dti-1332	516	6	interference	interference	NOUN
dti-1332	516	7	effectors	effector	NOUN
dti-1332	516	8	via	via	ADP
dti-1332	516	9	in	in	ADP
dti-1332	516	10	vitro	vitro	X
dti-1332	516	11	-	-	PUNCT
dti-1332	516	12	packaged	package	VERB
dti-1332	516	13	sv40	sv40	PROPN
dti-1332	516	14	psedovirions	psedovirion	NOUN
dti-1332	516	15	.	.	PUNCT
dti-1332	517	1	hum	hum	ADJ
dti-1332	517	2	.	.	PUNCT
dti-1332	518	1	gene	gene	NOUN
dti-1332	518	2	ther	ther	ADV
dti-1332	518	3	.	.	PUNCT
dti-1332	518	4	,	,	PUNCT
dti-1332	519	1	16:1110–5	16:1110–5	X
dti-1332	519	2	.	.	PUNCT
dti-1332	519	3	klebe	klebe	PROPN
dti-1332	519	4	,	,	PUNCT
dti-1332	519	5	s.	s.	PROPN
dti-1332	519	6	,	,	PUNCT
dti-1332	519	7	durr	durr	PROPN
dti-1332	519	8	,	,	PUNCT
dti-1332	519	9	a.	a.	NOUN
dti-1332	519	10	,	,	PUNCT
dti-1332	519	11	rentschler	rentschler	NOUN
dti-1332	519	12	,	,	PUNCT
dti-1332	519	13	a.	a.	PROPN
dti-1332	519	14	et	et	PROPN
dti-1332	519	15	al	al	PROPN
dti-1332	519	16	.	.	PROPN
dti-1332	519	17	2005	2005	NUM
dti-1332	519	18	.	.	PUNCT
dti-1332	520	1	new	new	ADJ
dti-1332	520	2	mutations	mutation	NOUN
dti-1332	520	3	in	in	ADP
dti-1332	520	4	protein	protein	NOUN
dti-1332	520	5	kinase	kinase	PROPN
dti-1332	520	6	cgamma	cgamma	PROPN
dti-1332	520	7	associated	associate	VERB
dti-1332	520	8	with	with	ADP
dti-1332	520	9	spinocerebellar	spinocerebellar	ADJ
dti-1332	520	10	ataxia	ataxia	NOUN
dti-1332	520	11	type	type	NOUN
dti-1332	520	12	14	14	NUM
dti-1332	520	13	.	.	PUNCT
dti-1332	521	1	ann	ann	PROPN
dti-1332	521	2	.	.	PUNCT
dti-1332	522	1	neurol	neurol	PROPN
dti-1332	522	2	.	.	PUNCT
dti-1332	522	3	,	,	PUNCT
dti-1332	523	1	58:720–9	58:720–9	NUM
dti-1332	523	2	.	.	PUNCT
dti-1332	524	1	knight	knight	PROPN
dti-1332	524	2	,	,	PUNCT
dti-1332	524	3	m.a	m.a	PROPN
dti-1332	524	4	.	.	PROPN
dti-1332	524	5	,	,	PUNCT
dti-1332	524	6	gardner	gardner	PROPN
dti-1332	524	7	,	,	PUNCT
dti-1332	524	8	r.j	r.j	PROPN
dti-1332	524	9	.	.	PROPN
dti-1332	524	10	,	,	PUNCT
dti-1332	524	11	bahlo	bahlo	NOUN
dti-1332	524	12	,	,	PUNCT
dti-1332	524	13	m.	m.	NOUN
dti-1332	524	14	et	et	PROPN
dti-1332	524	15	al	al	PROPN
dti-1332	524	16	.	.	PROPN
dti-1332	524	17	2004	2004	NUM
dti-1332	524	18	.	.	PUNCT
dti-1332	525	1	dominantly	dominantly	ADV
dti-1332	525	2	inherited	inherit	VERB
dti-1332	525	3	ataxia	ataxia	NOUN
dti-1332	525	4	and	and	CCONJ
dti-1332	525	5	dysphonia	dysphonia	NOUN
dti-1332	525	6	with	with	ADP
dti-1332	525	7	dentate	dentate	ADJ
dti-1332	525	8	calcifi	calcifi	NOUN
dti-1332	525	9	cation	cation	NOUN
dti-1332	525	10	:	:	PUNCT
dti-1332	525	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	525	12	ataxia	ataxia	NOUN
dti-1332	525	13	type	type	NOUN
dti-1332	525	14	20	20	NUM
dti-1332	525	15	.	.	PUNCT
dti-1332	526	1	brain	brain	NOUN
dti-1332	526	2	,	,	PUNCT
dti-1332	526	3	127:1172–81	127:1172–81	NUM
dti-1332	526	4	.	.	PUNCT
dti-1332	527	1	knight	knight	PROPN
dti-1332	527	2	,	,	PUNCT
dti-1332	527	3	m.a	m.a	PROPN
dti-1332	527	4	.	.	PROPN
dti-1332	527	5	,	,	PUNCT
dti-1332	527	6	kennerson	kennerson	PROPN
dti-1332	527	7	,	,	PUNCT
dti-1332	527	8	m.	m.	NOUN
dti-1332	527	9	,	,	PUNCT
dti-1332	527	10	nicholson	nicholson	PROPN
dti-1332	527	11	,	,	PUNCT
dti-1332	527	12	g.a	g.a	PROPN
dti-1332	527	13	.	.	PROPN
dti-1332	527	14	et	et	PROPN
dti-1332	527	15	al	al	PROPN
dti-1332	527	16	.	.	PROPN
dti-1332	527	17	2001	2001	NUM
dti-1332	527	18	.	.	PUNCT
dti-1332	528	1	a	a	DET
dti-1332	528	2	new	new	ADJ
dti-1332	528	3	spinocerebellar	spinocerebellar	ADJ
dti-1332	528	4	ataxia	ataxia	NOUN
dti-1332	528	5	,	,	PUNCT
dti-1332	528	6	sca15	sca15	NOUN
dti-1332	528	7	.	.	PUNCT
dti-1332	529	1	am	be	AUX
dti-1332	529	2	.	.	PUNCT
dti-1332	530	1	j.	j.	PROPN
dti-1332	530	2	hum	hum	PROPN
dti-1332	530	3	.	.	PUNCT
dti-1332	531	1	genet	genet	PROPN
dti-1332	531	2	.	.	PUNCT
dti-1332	531	3	,	,	PUNCT
dti-1332	531	4	69:509	69:509	PROPN
dti-1332	531	5	.	.	PUNCT
dti-1332	532	1	knight	knight	PROPN
dti-1332	532	2	,	,	PUNCT
dti-1332	532	3	m.a	m.a	PROPN
dti-1332	532	4	.	.	PROPN
dti-1332	532	5	,	,	PUNCT
dti-1332	532	6	kennerson	kennerson	PROPN
dti-1332	532	7	,	,	PUNCT
dti-1332	532	8	m.l	m.l	PROPN
dti-1332	532	9	.	.	PROPN
dti-1332	532	10	,	,	PUNCT
dti-1332	532	11	anney	anney	PROPN
dti-1332	532	12	,	,	PUNCT
dti-1332	532	13	r.j	r.j	PROPN
dti-1332	532	14	.	.	PROPN
dti-1332	532	15	et	et	PROPN
dti-1332	532	16	al	al	PROPN
dti-1332	532	17	.	.	PROPN
dti-1332	532	18	2003	2003	NUM
dti-1332	532	19	.	.	PUNCT
dti-1332	533	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	533	2	ataxia	ataxia	NOUN
dti-1332	533	3	type	type	NOUN
dti-1332	533	4	15	15	NUM
dti-1332	533	5	(	(	PUNCT
dti-1332	533	6	sca15	sca15	NOUN
dti-1332	533	7	)	)	PUNCT
dti-1332	533	8	maps	map	NOUN
dti-1332	533	9	to	to	ADP
dti-1332	533	10	3p24.2	3p24.2	NUM
dti-1332	533	11	-	-	PUNCT
dti-1332	533	12	3pter	3pter	NUM
dti-1332	533	13	:	:	PUNCT
dti-1332	533	14	exclusion	exclusion	NOUN
dti-1332	533	15	of	of	ADP
dti-1332	533	16	the	the	DET
dti-1332	533	17	itpr1	itpr1	NOUN
dti-1332	533	18	gene	gene	NOUN
dti-1332	533	19	,	,	PUNCT
dti-1332	533	20	the	the	DET
dti-1332	533	21	human	human	ADJ
dti-1332	533	22	orthologue	orthologue	NOUN
dti-1332	533	23	of	of	ADP
dti-1332	533	24	an	an	DET
dti-1332	533	25	ataxic	ataxic	ADJ
dti-1332	533	26	mouse	mouse	NOUN
dti-1332	533	27	mutant	mutant	NOUN
dti-1332	533	28	.	.	PUNCT
dti-1332	534	1	neurobiol	neurobiol	NOUN
dti-1332	534	2	.	.	PUNCT
dti-1332	535	1	dis	dis	PROPN
dti-1332	535	2	.	.	PROPN
dti-1332	535	3	,	,	PUNCT
dti-1332	535	4	13:147–57	13:147–57	ADJ
dti-1332	535	5	.	.	PUNCT
dti-1332	536	1	koide	koide	PROPN
dti-1332	536	2	,	,	PUNCT
dti-1332	536	3	r.	r.	PROPN
dti-1332	536	4	,	,	PUNCT
dti-1332	536	5	ikeuchi	ikeuchi	ADJ
dti-1332	536	6	,	,	PUNCT
dti-1332	536	7	t.	t.	PROPN
dti-1332	536	8	,	,	PUNCT
dti-1332	536	9	onodera	onodera	NOUN
dti-1332	536	10	,	,	PUNCT
dti-1332	536	11	o.	o.	NOUN
dti-1332	536	12	et	et	PROPN
dti-1332	536	13	al	al	PROPN
dti-1332	536	14	.	.	PROPN
dti-1332	536	15	1994	1994	NUM
dti-1332	536	16	.	.	PUNCT
dti-1332	537	1	unstable	unstable	ADJ
dti-1332	537	2	expansion	expansion	NOUN
dti-1332	537	3	of	of	ADP
dti-1332	537	4	cag	cag	PROPN
dti-1332	537	5	repeat	repeat	VERB
dti-1332	537	6	in	in	ADP
dti-1332	537	7	hereditary	hereditary	ADJ
dti-1332	537	8	dentatorubral	dentatorubral	ADJ
dti-1332	537	9	—	—	PUNCT
dti-1332	537	10	pallidoluysian	pallidoluysian	ADJ
dti-1332	537	11	atrophy	atrophy	NOUN
dti-1332	537	12	(	(	PUNCT
dti-1332	537	13	drpla	drpla	ADJ
dti-1332	537	14	)	)	PUNCT
dti-1332	537	15	.	.	PUNCT
dti-1332	538	1	nature	nature	NOUN
dti-1332	538	2	genetics	genetic	NOUN
dti-1332	538	3	,	,	PUNCT
dti-1332	538	4	6:9–13	6:9–13	NOUN
dti-1332	538	5	.	.	PUNCT
dti-1332	539	1	kopito	kopito	PROPN
dti-1332	539	2	,	,	PUNCT
dti-1332	539	3	r.r	r.r	PROPN
dti-1332	539	4	.	.	PROPN
dti-1332	539	5	2000	2000	NUM
dti-1332	539	6	.	.	PUNCT
dti-1332	540	1	aggresomes	aggresome	NOUN
dti-1332	540	2	,	,	PUNCT
dti-1332	540	3	inclusion	inclusion	NOUN
dti-1332	540	4	bodies	body	NOUN
dti-1332	540	5	and	and	CCONJ
dti-1332	540	6	protein	protein	NOUN
dti-1332	540	7	aggregation	aggregation	NOUN
dti-1332	540	8	.	.	PUNCT
dti-1332	541	1	trends	trend	NOUN
dti-1332	541	2	cell	cell	VERB
dti-1332	541	3	.	.	PUNCT
dti-1332	542	1	biol	biol	PROPN
dti-1332	542	2	.	.	PUNCT
dti-1332	542	3	,	,	PUNCT
dti-1332	542	4	10:524–30	10:524–30	PROPN
dti-1332	542	5	.	.	PUNCT
dti-1332	543	1	koob	koob	PROPN
dti-1332	543	2	,	,	PUNCT
dti-1332	543	3	m.l	m.l	PROPN
dti-1332	543	4	.	.	PROPN
dti-1332	543	5	,	,	PUNCT
dti-1332	543	6	moseley	moseley	PROPN
dti-1332	543	7	,	,	PUNCT
dti-1332	543	8	l.j	l.j	PROPN
dti-1332	543	9	.	.	PROPN
dti-1332	543	10	,	,	PUNCT
dti-1332	543	11	benzow	benzow	PROPN
dti-1332	543	12	,	,	PUNCT
dti-1332	543	13	k.a	k.a	PROPN
dti-1332	543	14	.	.	PROPN
dti-1332	543	15	et	et	PROPN
dti-1332	543	16	al	al	PROPN
dti-1332	543	17	.	.	PROPN
dti-1332	543	18	1999	1999	NUM
dti-1332	543	19	.	.	PUNCT
dti-1332	544	1	an	an	DET
dti-1332	544	2	untranslated	untranslated	ADJ
dti-1332	544	3	ctg	ctg	NOUN
dti-1332	544	4	expansion	expansion	NOUN
dti-1332	544	5	causes	cause	VERB
dti-1332	544	6	a	a	DET
dti-1332	544	7	novel	novel	ADJ
dti-1332	544	8	form	form	NOUN
dti-1332	544	9	of	of	ADP
dti-1332	544	10	spinocerebellar	spinocerebellar	ADJ
dti-1332	544	11	ataxia	ataxia	NOUN
dti-1332	544	12	(	(	PUNCT
dti-1332	544	13	sca8	sca8	PROPN
dti-1332	544	14	)	)	PUNCT
dti-1332	544	15	.	.	PUNCT
dti-1332	545	1	nature	nature	NOUN
dti-1332	545	2	genetics	genetic	NOUN
dti-1332	545	3	,	,	PUNCT
dti-1332	545	4	21:379–84	21:379–84	NOUN
dti-1332	545	5	.	.	PUNCT
dti-1332	546	1	kreuter	kreuter	NOUN
dti-1332	546	2	,	,	PUNCT
dti-1332	546	3	j.	j.	PROPN
dti-1332	546	4	2001	2001	NUM
dti-1332	546	5	.	.	PUNCT
dti-1332	547	1	nanoparticulate	nanoparticulate	ADJ
dti-1332	547	2	systems	system	NOUN
dti-1332	547	3	for	for	ADP
dti-1332	547	4	brain	brain	NOUN
dti-1332	547	5	delivery	delivery	NOUN
dti-1332	547	6	of	of	ADP
dti-1332	547	7	drugs	drug	NOUN
dti-1332	547	8	.	.	PUNCT
dti-1332	548	1	advanced	advanced	ADJ
dti-1332	548	2	drug	drug	NOUN
dti-1332	548	3	delivery	delivery	NOUN
dti-1332	548	4	reviews	review	NOUN
dti-1332	548	5	,	,	PUNCT
dti-1332	548	6	47:65–81	47:65–81	NUM
dti-1332	548	7	.	.	PUNCT
dti-1332	549	1	krichevsky	krichevsky	PROPN
dti-1332	549	2	,	,	PUNCT
dti-1332	549	3	a.m.	a.m.	PROPN
dti-1332	549	4	and	and	CCONJ
dti-1332	549	5	kosik	kosik	PROPN
dti-1332	549	6	,	,	PUNCT
dti-1332	549	7	k.s	k.s	PROPN
dti-1332	549	8	.	.	PROPN
dti-1332	549	9	2002	2002	NUM
dti-1332	549	10	.	.	PUNCT
dti-1332	550	1	rnai	rnai	PROPN
dti-1332	550	2	functions	function	NOUN
dti-1332	550	3	in	in	ADP
dti-1332	550	4	cultured	cultured	ADJ
dti-1332	550	5	mammalian	mammalian	ADJ
dti-1332	550	6	neurons	neuron	NOUN
dti-1332	550	7	.	.	PUNCT
dti-1332	551	1	proc	proc	NOUN
dti-1332	551	2	.	.	PUNCT
dti-1332	552	1	natl	natl	PROPN
dti-1332	552	2	.	.	PUNCT
dti-1332	553	1	acad	acad	PROPN
dti-1332	553	2	.	.	PUNCT
dti-1332	554	1	sci	sci	PROPN
dti-1332	554	2	.	.	PUNCT
dti-1332	554	3	u.s.a	u.s.a	PROPN
dti-1332	554	4	.	.	PROPN
dti-1332	554	5	,	,	PUNCT
dti-1332	554	6	99:11926–9	99:11926–9	X
dti-1332	554	7	.	.	PUNCT
dti-1332	555	1	labhasetwar	labhasetwar	PROPN
dti-1332	555	2	,	,	PUNCT
dti-1332	555	3	v.	v.	ADV
dti-1332	555	4	,	,	PUNCT
dti-1332	555	5	song	song	NOUN
dti-1332	555	6	,	,	PUNCT
dti-1332	555	7	c.	c.	PROPN
dti-1332	555	8	,	,	PUNCT
dti-1332	555	9	humphrey	humphrey	PROPN
dti-1332	555	10	,	,	PUNCT
dti-1332	555	11	w.	w.	PROPN
dti-1332	555	12	et	et	PROPN
dti-1332	555	13	al	al	PROPN
dti-1332	555	14	.	.	PROPN
dti-1332	555	15	1998	1998	NUM
dti-1332	555	16	.	.	PUNCT
dti-1332	556	1	arterial	arterial	ADJ
dti-1332	556	2	uptake	uptake	NOUN
dti-1332	556	3	of	of	ADP
dti-1332	556	4	biodegradable	biodegradable	ADJ
dti-1332	556	5	nanoparticles	nanoparticle	NOUN
dti-1332	556	6	:	:	PUNCT
dti-1332	556	7	effect	effect	NOUN
dti-1332	556	8	of	of	ADP
dti-1332	556	9	surface	surface	NOUN
dti-1332	556	10	modifications	modification	NOUN
dti-1332	556	11	.	.	PUNCT
dti-1332	557	1	j.	j.	PROPN
dti-1332	557	2	pharm	pharm	PROPN
dti-1332	557	3	.	.	PUNCT
dti-1332	558	1	sci	sci	PROPN
dti-1332	558	2	.	.	PROPN
dti-1332	558	3	,	,	PUNCT
dti-1332	558	4	87:1229–34	87:1229–34	NUM
dti-1332	558	5	.	.	PUNCT
dti-1332	559	1	lasek	lasek	PROPN
dti-1332	559	2	,	,	PUNCT
dti-1332	559	3	k.	k.	PROPN
dti-1332	559	4	,	,	PUNCT
dti-1332	559	5	lencer	lencer	PROPN
dti-1332	559	6	,	,	PUNCT
dti-1332	559	7	r.	r.	PROPN
dti-1332	559	8	,	,	PUNCT
dti-1332	559	9	gaser	gaser	NOUN
dti-1332	559	10	,	,	PUNCT
dti-1332	559	11	c.	c.	PROPN
dti-1332	559	12	et	et	PROPN
dti-1332	559	13	al	al	PROPN
dti-1332	559	14	.	.	PROPN
dti-1332	559	15	2006	2006	NUM
dti-1332	559	16	.	.	PUNCT
dti-1332	560	1	morphological	morphological	ADJ
dti-1332	560	2	basis	basis	NOUN
dti-1332	560	3	for	for	ADP
dti-1332	560	4	the	the	DET
dti-1332	560	5	spectrum	spectrum	NOUN
dti-1332	560	6	of	of	ADP
dti-1332	560	7	clinical	clinical	ADJ
dti-1332	560	8	defi	defi	NOUN
dti-1332	560	9	cits	cit	NOUN
dti-1332	560	10	in	in	ADP
dti-1332	560	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	560	12	ataxia	ataxia	NOUN
dti-1332	560	13	17	17	NUM
dti-1332	560	14	(	(	PUNCT
dti-1332	560	15	sca17	sca17	NOUN
dti-1332	560	16	)	)	PUNCT
dti-1332	560	17	.	.	PUNCT
dti-1332	561	1	brain	brain	NOUN
dti-1332	561	2	,	,	PUNCT
dti-1332	561	3	129:2341–52	129:2341–52	NUM
dti-1332	561	4	.	.	PUNCT
dti-1332	562	1	lin	lin	PROPN
dti-1332	562	2	,	,	PUNCT
dti-1332	562	3	x.	x.	PROPN
dti-1332	562	4	,	,	PUNCT
dti-1332	562	5	antalffy	antalffy	PROPN
dti-1332	562	6	,	,	PUNCT
dti-1332	562	7	b.	b.	PROPN
dti-1332	562	8	,	,	PUNCT
dti-1332	562	9	kang	kang	PROPN
dti-1332	562	10	,	,	PUNCT
dti-1332	562	11	d.	d.	PROPN
dti-1332	562	12	et	et	PROPN
dti-1332	562	13	al	al	PROPN
dti-1332	562	14	.	.	PROPN
dti-1332	562	15	2000	2000	NUM
dti-1332	562	16	.	.	PUNCT
dti-1332	563	1	polyglutamine	polyglutamine	NOUN
dti-1332	563	2	expansion	expansion	NOUN
dti-1332	563	3	downregulates	downregulate	VERB
dti-1332	563	4	specifi	specifi	PROPN
dti-1332	563	5	c	c	PROPN
dti-1332	563	6	neuronal	neuronal	ADJ
dti-1332	563	7	genes	gene	NOUN
dti-1332	563	8	before	before	ADP
dti-1332	563	9	pathologic	pathologic	ADJ
dti-1332	563	10	changes	change	NOUN
dti-1332	563	11	in	in	ADP
dti-1332	563	12	sca1	sca1	NOUN
dti-1332	563	13	.	.	PUNCT
dti-1332	564	1	nature	nature	NOUN
dti-1332	564	2	neuroscience	neuroscience	NOUN
dti-1332	564	3	,	,	PUNCT
dti-1332	564	4	3:157–163	3:157–163	NUM
dti-1332	564	5	.	.	PUNCT
dti-1332	565	1	lin	lin	PROPN
dti-1332	565	2	,	,	PUNCT
dti-1332	565	3	x.	x.	PROPN
dti-1332	565	4	and	and	CCONJ
dti-1332	565	5	ashizawa	ashizawa	PROPN
dti-1332	565	6	,	,	PUNCT
dti-1332	565	7	t.	t.	PROPN
dti-1332	565	8	2005	2005	NUM
dti-1332	565	9	.	.	PUNCT
dti-1332	566	1	recent	recent	ADJ
dti-1332	566	2	progress	progress	NOUN
dti-1332	566	3	in	in	ADP
dti-1332	566	4	spinocerebellar	spinocerebellar	ADJ
dti-1332	566	5	ataxia	ataxia	NOUN
dti-1332	566	6	type-10	type-10	PROPN
dti-1332	566	7	(	(	PUNCT
dti-1332	566	8	sca10	sca10	PROPN
dti-1332	566	9	)	)	PUNCT
dti-1332	566	10	.	.	PUNCT
dti-1332	567	1	cerebellum	cerebellum	PROPN
dti-1332	567	2	,	,	PUNCT
dti-1332	567	3	4:37–42	4:37–42	NUM
dti-1332	567	4	.	.	PUNCT
dti-1332	568	1	lu	lu	PROPN
dti-1332	568	2	,	,	PUNCT
dti-1332	568	3	p.y	p.y	PROPN
dti-1332	568	4	.	.	PROPN
dti-1332	568	5	,	,	PUNCT
dti-1332	568	6	xie	xie	PROPN
dti-1332	568	7	,	,	PUNCT
dti-1332	568	8	f.	f.	PROPN
dti-1332	568	9	and	and	CCONJ
dti-1332	568	10	woodle	woodle	PROPN
dti-1332	568	11	,	,	PUNCT
dti-1332	568	12	m.c	m.c	PROPN
dti-1332	568	13	.	.	PROPN
dti-1332	568	14	2005	2005	NUM
dti-1332	568	15	.	.	PUNCT
dti-1332	569	1	in	in	ADP
dti-1332	569	2	vivo	vivo	ADJ
dti-1332	569	3	application	application	NOUN
dti-1332	569	4	of	of	ADP
dti-1332	569	5	rna	rna	NOUN
dti-1332	569	6	interference	interference	NOUN
dti-1332	569	7	:	:	PUNCT
dti-1332	569	8	from	from	ADP
dti-1332	569	9	functional	functional	ADJ
dti-1332	569	10	genomics	genomic	NOUN
dti-1332	569	11	to	to	ADP
dti-1332	569	12	therapeutics	therapeutic	NOUN
dti-1332	569	13	.	.	PUNCT
dti-1332	570	1	adv	adv	PROPN
dti-1332	570	2	.	.	PUNCT
dti-1332	570	3	genet	genet	PROPN
dti-1332	570	4	.	.	PUNCT
dti-1332	571	1	,	,	PUNCT
dti-1332	571	2	54:117–42	54:117–42	NOUN
dti-1332	571	3	.	.	PUNCT
dti-1332	572	1	maltecca	maltecca	PROPN
dti-1332	572	2	,	,	PUNCT
dti-1332	572	3	f.	f.	PROPN
dti-1332	572	4	,	,	PUNCT
dti-1332	572	5	filla	filla	PROPN
dti-1332	572	6	,	,	PUNCT
dti-1332	572	7	a.	a.	PROPN
dti-1332	572	8	,	,	PUNCT
dti-1332	572	9	castaldo	castaldo	NOUN
dti-1332	572	10	,	,	PUNCT
dti-1332	572	11	i.	i.	PROPN
dti-1332	572	12	et	et	PROPN
dti-1332	572	13	al	al	PROPN
dti-1332	572	14	.	.	PROPN
dti-1332	572	15	2003	2003	NUM
dti-1332	572	16	.	.	PUNCT
dti-1332	573	1	intergenerational	intergenerational	ADJ
dti-1332	573	2	instability	instability	NOUN
dti-1332	573	3	and	and	CCONJ
dti-1332	573	4	marked	mark	VERB
dti-1332	573	5	anticipation	anticipation	NOUN
dti-1332	573	6	in	in	ADP
dti-1332	573	7	sca-17	sca-17	PROPN
dti-1332	573	8	.	.	PUNCT
dti-1332	573	9	neurology	neurology	NOUN
dti-1332	573	10	,	,	PUNCT
dti-1332	573	11	61:1441–3	61:1441–3	NUM
dti-1332	573	12	.	.	PUNCT
dti-1332	574	1	matsuyama	matsuyama	PROPN
dti-1332	574	2	,	,	PUNCT
dti-1332	574	3	z.	z.	PROPN
dti-1332	574	4	,	,	PUNCT
dti-1332	574	5	kawakami	kawakami	PROPN
dti-1332	574	6	,	,	PUNCT
dti-1332	574	7	h.	h.	PROPN
dti-1332	574	8	,	,	PUNCT
dti-1332	574	9	maruyama	maruyama	PROPN
dti-1332	574	10	,	,	PUNCT
dti-1332	574	11	h.	h.	PROPN
dti-1332	574	12	et	et	PROPN
dti-1332	574	13	al	al	PROPN
dti-1332	574	14	.	.	PROPN
dti-1332	574	15	1997	1997	NUM
dti-1332	574	16	.	.	PUNCT
dti-1332	575	1	molecular	molecular	ADJ
dti-1332	575	2	features	feature	NOUN
dti-1332	575	3	of	of	ADP
dti-1332	575	4	the	the	DET
dti-1332	575	5	cag	cag	PROPN
dti-1332	575	6	repeats	repeat	NOUN
dti-1332	575	7	of	of	ADP
dti-1332	575	8	spinocerebellar	spinocerebellar	ADJ
dti-1332	575	9	ataxia	ataxia	NOUN
dti-1332	575	10	6	6	NUM
dti-1332	575	11	(	(	PUNCT
dti-1332	575	12	sca6	sca6	PROPN
dti-1332	575	13	)	)	PUNCT
dti-1332	575	14	.	.	PUNCT
dti-1332	576	1	hum	hum	PROPN
dti-1332	576	2	.	.	PUNCT
dti-1332	577	1	mol	mol	PROPN
dti-1332	577	2	.	.	PUNCT
dti-1332	578	1	genet	genet	PROPN
dti-1332	578	2	.	.	PUNCT
dti-1332	579	1	,	,	PUNCT
dti-1332	579	2	6:1283–7	6:1283–7	NOUN
dti-1332	579	3	.	.	PUNCT
dti-1332	580	1	mazarakis	mazarakis	PROPN
dti-1332	580	2	,	,	PUNCT
dti-1332	580	3	n.d	n.d	PROPN
dti-1332	580	4	.	.	PROPN
dti-1332	580	5	,	,	PUNCT
dti-1332	580	6	azzouz	azzouz	PROPN
dti-1332	580	7	,	,	PUNCT
dti-1332	580	8	m.	m.	NOUN
dti-1332	580	9	,	,	PUNCT
dti-1332	580	10	rohll	rohll	ADJ
dti-1332	580	11	,	,	PUNCT
dti-1332	580	12	j.b	j.b	PROPN
dti-1332	580	13	.	.	PUNCT
dti-1332	580	14	et	et	PROPN
dti-1332	580	15	al	al	PROPN
dti-1332	580	16	.	.	PROPN
dti-1332	580	17	2001	2001	NUM
dti-1332	580	18	.	.	PUNCT
dti-1332	581	1	rabies	rabie	NOUN
dti-1332	581	2	virus	virus	NOUN
dti-1332	581	3	glycoprotein	glycoprotein	NOUN
dti-1332	581	4	pseudotyping	pseudotype	VERB
dti-1332	581	5	of	of	ADP
dti-1332	581	6	lentiviral	lentiviral	ADJ
dti-1332	581	7	vectors	vector	NOUN
dti-1332	581	8	enables	enable	VERB
dti-1332	581	9	retrograde	retrograde	VERB
dti-1332	581	10	axonal	axonal	ADJ
dti-1332	581	11	transportand	transportand	NOUN
dti-1332	581	12	access	access	NOUN
dti-1332	581	13	to	to	ADP
dti-1332	581	14	the	the	DET
dti-1332	581	15	nervous	nervous	ADJ
dti-1332	581	16	system	system	NOUN
dti-1332	581	17	after	after	ADP
dti-1332	581	18	periphery	periphery	ADJ
dti-1332	581	19	delivery	delivery	NOUN
dti-1332	581	20	.	.	PUNCT
dti-1332	582	1	hum	hum	ADJ
dti-1332	582	2	.	.	PUNCT
dti-1332	583	1	mol	mol	PROPN
dti-1332	583	2	.	.	PUNCT
dti-1332	583	3	genet	genet	PROPN
dti-1332	583	4	.	.	PUNCT
dti-1332	584	1	,	,	PUNCT
dti-1332	585	1	10:2109–21	10:2109–21	X
dti-1332	585	2	.	.	PUNCT
dti-1332	586	1	mcneil	mcneil	PROPN
dti-1332	586	2	,	,	PUNCT
dti-1332	586	3	s.e	s.e	PROPN
dti-1332	586	4	.	.	PROPN
dti-1332	586	5	2005	2005	NUM
dti-1332	586	6	.	.	PUNCT
dti-1332	587	1	nanotechnology	nanotechnology	NOUN
dti-1332	587	2	for	for	ADP
dti-1332	587	3	the	the	DET
dti-1332	587	4	biologist	biologist	NOUN
dti-1332	587	5	.	.	PUNCT
dti-1332	588	1	j.	j.	PROPN
dti-1332	588	2	leukoc	leukoc	PROPN
dti-1332	588	3	.	.	PUNCT
dti-1332	589	1	biol	biol	PROPN
dti-1332	589	2	.	.	PUNCT
dti-1332	589	3	,	,	PUNCT
dti-1332	589	4	78:585–94	78:585–94	NOUN
dti-1332	589	5	.	.	PUNCT
dti-1332	590	1	meijer	meijer	PROPN
dti-1332	590	2	,	,	PUNCT
dti-1332	590	3	i.a	i.a	PROPN
dti-1332	590	4	.	.	PROPN
dti-1332	590	5	,	,	PUNCT
dti-1332	590	6	hand	hand	PROPN
dti-1332	590	7	,	,	PUNCT
dti-1332	590	8	c.k	c.k	PROPN
dti-1332	590	9	.	.	PROPN
dti-1332	590	10	,	,	PUNCT
dti-1332	590	11	grewal	grewal	PROPN
dti-1332	590	12	,	,	PUNCT
dti-1332	590	13	k.k	k.k	PROPN
dti-1332	590	14	.	.	PROPN
dti-1332	590	15	et	et	PROPN
dti-1332	590	16	al	al	PROPN
dti-1332	590	17	.	.	PROPN
dti-1332	590	18	2002	2002	NUM
dti-1332	590	19	.	.	PUNCT
dti-1332	591	1	a	a	DET
dti-1332	591	2	locus	locus	NOUN
dti-1332	591	3	for	for	ADP
dti-1332	591	4	autosomal	autosomal	ADJ
dti-1332	591	5	dominant	dominant	ADJ
dti-1332	591	6	hereditary	hereditary	ADJ
dti-1332	591	7	spastic	spastic	ADJ
dti-1332	591	8	ataxia	ataxia	NOUN
dti-1332	591	9	,	,	PUNCT
dti-1332	591	10	sax1	sax1	NOUN
dti-1332	591	11	,	,	PUNCT
dti-1332	591	12	maps	map	NOUN
dti-1332	591	13	to	to	PART
dti-1332	591	14	chromosome	chromosome	VERB
dti-1332	591	15	12p13	12p13	NUM
dti-1332	591	16	.	.	PUNCT
dti-1332	592	1	am	be	AUX
dti-1332	592	2	.	.	PUNCT
dti-1332	593	1	j.	j.	PROPN
dti-1332	593	2	hum	hum	PROPN
dti-1332	593	3	.	.	PUNCT
dti-1332	594	1	genet	genet	PROPN
dti-1332	594	2	.	.	PUNCT
dti-1332	594	3	,	,	PUNCT
dti-1332	595	1	70:763–9	70:763–9	X
dti-1332	595	2	.	.	PUNCT
dti-1332	596	1	miller	miller	PROPN
dti-1332	596	2	,	,	PUNCT
dti-1332	596	3	v.m	v.m	PROPN
dti-1332	596	4	.	.	PROPN
dti-1332	596	5	,	,	PUNCT
dti-1332	596	6	xia	xia	PROPN
dti-1332	596	7	,	,	PUNCT
dti-1332	596	8	h.	h.	PROPN
dti-1332	596	9	,	,	PUNCT
dti-1332	596	10	marrs	marrs	PROPN
dti-1332	596	11	,	,	PUNCT
dti-1332	596	12	g.l	g.l	PROPN
dti-1332	596	13	.	.	PROPN
dti-1332	596	14	et	et	PROPN
dti-1332	596	15	al	al	PROPN
dti-1332	596	16	.	.	PROPN
dti-1332	596	17	2003	2003	NUM
dti-1332	596	18	.	.	PUNCT
dti-1332	597	1	allele	allele	PROPN
dti-1332	597	2	specifi	specifi	PROPN
dti-1332	597	3	c	c	PROPN
dti-1332	597	4	silencing	silence	VERB
dti-1332	597	5	of	of	ADP
dti-1332	597	6	dominant	dominant	ADJ
dti-1332	597	7	disease	disease	NOUN
dti-1332	597	8	genes	gene	NOUN
dti-1332	597	9	.	.	PUNCT
dti-1332	598	1	proc	proc	NOUN
dti-1332	598	2	.	.	PUNCT
dti-1332	599	1	natl	natl	PROPN
dti-1332	599	2	.	.	PUNCT
dti-1332	600	1	acad	acad	PROPN
dti-1332	600	2	.	.	PUNCT
dti-1332	601	1	sci	sci	PROPN
dti-1332	601	2	.	.	PUNCT
dti-1332	601	3	u.s.a	u.s.a	PROPN
dti-1332	601	4	.	.	PROPN
dti-1332	601	5	,	,	PUNCT
dti-1332	601	6	100:7195–200	100:7195–200	PROPN
dti-1332	601	7	.	.	PUNCT
dti-1332	602	1	miller	miller	PROPN
dti-1332	602	2	,	,	PUNCT
dti-1332	602	3	v.m	v.m	PROPN
dti-1332	602	4	.	.	PROPN
dti-1332	602	5	,	,	PUNCT
dti-1332	602	6	gouvion	gouvion	PROPN
dti-1332	602	7	,	,	PUNCT
dti-1332	602	8	c.m	c.m	PROPN
dti-1332	602	9	.	.	PROPN
dti-1332	602	10	,	,	PUNCT
dti-1332	602	11	davidson	davidson	PROPN
dti-1332	602	12	,	,	PUNCT
dti-1332	602	13	b.l	b.l	PROPN
dti-1332	602	14	.	.	PROPN
dti-1332	602	15	et	et	PROPN
dti-1332	602	16	al	al	PROPN
dti-1332	602	17	.	.	PROPN
dti-1332	602	18	2004	2004	NUM
dti-1332	602	19	.	.	PUNCT
dti-1332	603	1	targeting	target	VERB
dti-1332	603	2	alzheimer	alzheimer	PROPN
dti-1332	603	3	’s	’s	PART
dti-1332	603	4	disease	disease	NOUN
dti-1332	603	5	genes	gene	NOUN
dti-1332	603	6	with	with	ADP
dti-1332	603	7	rna	rna	NOUN
dti-1332	603	8	interference	interference	NOUN
dti-1332	603	9	:	:	PUNCT
dti-1332	603	10	an	an	DET
dti-1332	603	11	efficient	efficient	ADJ
dti-1332	603	12	strategy	strategy	NOUN
dti-1332	603	13	for	for	ADP
dti-1332	603	14	silencing	silence	VERB
dti-1332	603	15	mutant	mutant	ADJ
dti-1332	603	16	alleles	allele	NOUN
dti-1332	603	17	.	.	PUNCT
dti-1332	604	1	nucleic	nucleic	ADJ
dti-1332	604	2	acids	acid	NOUN
dti-1332	604	3	res	re	NOUN
dti-1332	604	4	.	.	PUNCT
dti-1332	604	5	,	,	PUNCT
dti-1332	604	6	32:661–8	32:661–8	NUM
dti-1332	604	7	.	.	PUNCT
dti-1332	605	1	miura	miura	PROPN
dti-1332	605	2	,	,	PUNCT
dti-1332	605	3	s.	s.	PROPN
dti-1332	605	4	,	,	PUNCT
dti-1332	605	5	shibata	shibata	PROPN
dti-1332	605	6	,	,	PUNCT
dti-1332	605	7	h.	h.	PROPN
dti-1332	605	8	,	,	PUNCT
dti-1332	605	9	furuya	furuya	PROPN
dti-1332	605	10	,	,	PUNCT
dti-1332	605	11	h.	h.	PROPN
dti-1332	605	12	et	et	PROPN
dti-1332	605	13	al	al	PROPN
dti-1332	605	14	.	.	PROPN
dti-1332	605	15	2006	2006	NUM
dti-1332	605	16	.	.	PUNCT
dti-1332	606	1	the	the	DET
dti-1332	606	2	contactin	contactin	ADJ
dti-1332	606	3	4	4	NUM
dti-1332	606	4	gene	gene	NOUN
dti-1332	606	5	locus	locus	NOUN
dti-1332	606	6	at	at	ADP
dti-1332	606	7	3p26	3p26	NUM
dti-1332	606	8	is	be	AUX
dti-1332	606	9	a	a	DET
dti-1332	606	10	candidate	candidate	NOUN
dti-1332	606	11	gene	gene	NOUN
dti-1332	606	12	of	of	ADP
dti-1332	606	13	sca16	sca16	PROPN
dti-1332	606	14	.	.	PUNCT
dti-1332	607	1	neurology	neurology	PROPN
dti-1332	607	2	,	,	PUNCT
dti-1332	607	3	67:1236–41	67:1236–41	NUM
dti-1332	607	4	.	.	PUNCT
dti-1332	608	1	miyoshi	miyoshi	PROPN
dti-1332	608	2	,	,	PUNCT
dti-1332	608	3	y.	y.	PROPN
dti-1332	608	4	,	,	PUNCT
dti-1332	608	5	yamada	yamada	PROPN
dti-1332	608	6	,	,	PUNCT
dti-1332	608	7	t.	t.	PROPN
dti-1332	608	8	,	,	PUNCT
dti-1332	608	9	tanimura	tanimura	ADV
dti-1332	608	10	,	,	PUNCT
dti-1332	608	11	m.	m.	NOUN
dti-1332	608	12	et	et	PROPN
dti-1332	608	13	al	al	PROPN
dti-1332	608	14	.	.	PROPN
dti-1332	608	15	2001	2001	NUM
dti-1332	608	16	.	.	PUNCT
dti-1332	609	1	a	a	DET
dti-1332	609	2	novel	novel	ADJ
dti-1332	609	3	autosomal	autosomal	ADJ
dti-1332	609	4	dominant	dominant	ADJ
dti-1332	609	5	spinocerebellar	spinocerebellar	ADJ
dti-1332	609	6	ataxia	ataxia	NOUN
dti-1332	609	7	(	(	PUNCT
dti-1332	609	8	sca16	sca16	NOUN
dti-1332	609	9	)	)	PUNCT
dti-1332	609	10	linked	link	VERB
dti-1332	609	11	to	to	PART
dti-1332	609	12	chromosome	chromosome	VERB
dti-1332	609	13	8q22.1	8q22.1	NUM
dti-1332	609	14	-	-	PUNCT
dti-1332	609	15	24.1	24.1	NUM
dti-1332	609	16	.	.	PUNCT
dti-1332	610	1	neurology	neurology	NOUN
dti-1332	610	2	,	,	PUNCT
dti-1332	610	3	57:96–100	57:96–100	NUM
dti-1332	610	4	.	.	PUNCT
dti-1332	611	1	molas	mola	NOUN
dti-1332	611	2	,	,	PUNCT
dti-1332	611	3	m.	m.	NOUN
dti-1332	611	4	,	,	PUNCT
dti-1332	611	5	gomez	gomez	PROPN
dti-1332	611	6	-	-	PUNCT
dti-1332	611	7	valades	valades	PROPN
dti-1332	611	8	,	,	PUNCT
dti-1332	611	9	a.g	a.g	PROPN
dti-1332	611	10	.	.	PROPN
dti-1332	611	11	,	,	PUNCT
dti-1332	611	12	vidalalabro	vidalalabro	PROPN
dti-1332	611	13	,	,	PUNCT
dti-1332	611	14	a.	a.	PROPN
dti-1332	611	15	et	et	PROPN
dti-1332	611	16	al	al	PROPN
dti-1332	611	17	.	.	PROPN
dti-1332	611	18	2003	2003	NUM
dti-1332	611	19	.	.	PUNCT
dti-1332	612	1	receptormediated	receptormediate	VERB
dti-1332	612	2	gene	gene	NOUN
dti-1332	612	3	transfer	transfer	NOUN
dti-1332	612	4	vectors	vector	NOUN
dti-1332	612	5	:	:	PUNCT
dti-1332	612	6	progress	progress	NOUN
dti-1332	612	7	towards	towards	ADP
dti-1332	612	8	genetic	genetic	ADJ
dti-1332	612	9	pharmaceuticals	pharmaceutical	NOUN
dti-1332	612	10	.	.	PUNCT
dti-1332	613	1	current	current	ADJ
dti-1332	613	2	gene	gene	NOUN
dti-1332	613	3	therapy	therapy	NOUN
dti-1332	613	4	,	,	PUNCT
dti-1332	614	1	3:468–85	3:468–85	PROPN
dti-1332	614	2	.	.	PUNCT
dti-1332	614	3	morar	morar	PROPN
dti-1332	614	4	,	,	PUNCT
dti-1332	614	5	a.s	a.s	PROPN
dti-1332	614	6	.	.	PROPN
dti-1332	614	7	,	,	PUNCT
dti-1332	614	8	schrimsher	schrimsher	NOUN
dti-1332	614	9	,	,	PUNCT
dti-1332	614	10	j.l	j.l	PROPN
dti-1332	614	11	.	.	PROPN
dti-1332	614	12	and	and	CCONJ
dti-1332	614	13	mark	mark	PROPN
dti-1332	614	14	,	,	PUNCT
dti-1332	614	15	d.	d.	PROPN
dti-1332	614	16	2006	2006	NUM
dti-1332	614	17	.	.	PUNCT
dti-1332	615	1	pegylation	pegylation	NOUN
dti-1332	615	2	of	of	ADP
dti-1332	615	3	proteins	protein	NOUN
dti-1332	615	4	a	a	DET
dti-1332	615	5	structural	structural	ADJ
dti-1332	615	6	approach	approach	NOUN
dti-1332	615	7	.	.	PUNCT
dti-1332	616	1	biopharm	biopharm	PROPN
dti-1332	616	2	international	international	PROPN
dti-1332	616	3	,	,	PUNCT
dti-1332	616	4	19	19	NUM
dti-1332	616	5	.	.	PUNCT
dti-1332	617	1	nogawa	nogawa	PROPN
dti-1332	617	2	,	,	PUNCT
dti-1332	617	3	m.	m.	NOUN
dti-1332	617	4	,	,	PUNCT
dti-1332	617	5	yuasa	yuasa	PROPN
dti-1332	617	6	,	,	PUNCT
dti-1332	617	7	t.	t.	PROPN
dti-1332	617	8	,	,	PUNCT
dti-1332	617	9	kimura	kimura	NOUN
dti-1332	617	10	,	,	PUNCT
dti-1332	617	11	s.	s.	PROPN
dti-1332	617	12	et	et	PROPN
dti-1332	617	13	al	al	PROPN
dti-1332	617	14	.	.	PROPN
dti-1332	617	15	2005	2005	NUM
dti-1332	617	16	.	.	PUNCT
dti-1332	618	1	intravesical	intravesical	ADJ
dti-1332	618	2	administration	administration	NOUN
dti-1332	618	3	of	of	ADP
dti-1332	618	4	small	small	ADJ
dti-1332	618	5	interfering	interfere	VERB
dti-1332	618	6	rna	rna	NOUN
dti-1332	618	7	targeting	target	VERB
dti-1332	618	8	plk-1	plk-1	ADV
dti-1332	618	9	successfully	successfully	ADV
dti-1332	618	10	prevents	prevent	VERB
dti-1332	618	11	the	the	DET
dti-1332	618	12	growth	growth	NOUN
dti-1332	618	13	of	of	ADP
dti-1332	618	14	bladder	bladder	NOUN
dti-1332	618	15	cancer	cancer	NOUN
dti-1332	618	16	.	.	PUNCT
dti-1332	619	1	j.	j.	PROPN
dti-1332	619	2	clin	clin	PROPN
dti-1332	619	3	.	.	PUNCT
dti-1332	620	1	invest	invest	PROPN
dti-1332	620	2	.	.	PUNCT
dti-1332	620	3	,	,	PUNCT
dti-1332	620	4	115:978–85	115:978–85	NUM
dti-1332	620	5	.	.	PUNCT
dti-1332	621	1	116	116	NUM
dti-1332	621	2	prakash	prakash	PROPN
dti-1332	621	3	and	and	CCONJ
dti-1332	621	4	malhotra	malhotra	PROPN
dti-1332	621	5	drug	drug	PROPN
dti-1332	621	6	target	target	NOUN
dti-1332	621	7	insights	insight	VERB
dti-1332	621	8	2008:3	2008:3	NUM
dti-1332	621	9	nakamura	nakamura	NOUN
dti-1332	621	10	,	,	PUNCT
dti-1332	621	11	k.	k.	PROPN
dti-1332	621	12	,	,	PUNCT
dti-1332	621	13	jeong	jeong	PROPN
dti-1332	621	14	,	,	PUNCT
dti-1332	621	15	s.y	s.y	PROPN
dti-1332	621	16	.	.	PROPN
dti-1332	621	17	,	,	PUNCT
dti-1332	621	18	uchihara	uchihara	ADJ
dti-1332	621	19	,	,	PUNCT
dti-1332	621	20	t.	t.	PROPN
dti-1332	621	21	et	et	PROPN
dti-1332	621	22	al	al	PROPN
dti-1332	621	23	.	.	PROPN
dti-1332	621	24	2001	2001	NUM
dti-1332	621	25	.	.	PUNCT
dti-1332	622	1	sca17	sca17	PROPN
dti-1332	622	2	,	,	PUNCT
dti-1332	622	3	a	a	DET
dti-1332	622	4	novel	novel	ADJ
dti-1332	622	5	autosomal	autosomal	ADJ
dti-1332	622	6	dominant	dominant	ADJ
dti-1332	622	7	cerebellar	cerebellar	PROPN
dti-1332	622	8	ataxia	ataxia	NOUN
dti-1332	622	9	caused	cause	VERB
dti-1332	622	10	by	by	ADP
dti-1332	622	11	an	an	DET
dti-1332	622	12	expanded	expand	VERB
dti-1332	622	13	polyglutamine	polyglutamine	NOUN
dti-1332	622	14	in	in	ADP
dti-1332	622	15	tata	tata	NOUN
dti-1332	622	16	-	-	PUNCT
dti-1332	622	17	binding	bind	VERB
dti-1332	622	18	protein	protein	NOUN
dti-1332	622	19	.	.	PUNCT
dti-1332	623	1	hum	hum	ADJ
dti-1332	623	2	.	.	PUNCT
dti-1332	624	1	mol	mol	PROPN
dti-1332	624	2	.	.	PUNCT
dti-1332	624	3	genet	genet	PROPN
dti-1332	624	4	.	.	PUNCT
dti-1332	625	1	,	,	PUNCT
dti-1332	626	1	10:1441–48	10:1441–48	NUM
dti-1332	626	2	.	.	PUNCT
dti-1332	627	1	nandagopal	nandagopal	PROPN
dti-1332	627	2	,	,	PUNCT
dti-1332	627	3	r.	r.	PROPN
dti-1332	627	4	and	and	CCONJ
dti-1332	627	5	moorthy	moorthy	PROPN
dti-1332	627	6	,	,	PUNCT
dti-1332	627	7	s.g	s.g	PROPN
dti-1332	627	8	.	.	PROPN
dti-1332	627	9	2004	2004	NUM
dti-1332	627	10	.	.	PUNCT
dti-1332	628	1	dramatic	dramatic	ADJ
dti-1332	628	2	levodopa	levodopa	NOUN
dti-1332	628	3	responsiveness	responsiveness	NOUN
dti-1332	628	4	of	of	ADP
dti-1332	628	5	dystonia	dystonia	NOUN
dti-1332	628	6	in	in	ADP
dti-1332	628	7	a	a	DET
dti-1332	628	8	sporadic	sporadic	ADJ
dti-1332	628	9	case	case	NOUN
dti-1332	628	10	of	of	ADP
dti-1332	628	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	628	12	ataxia	ataxia	NOUN
dti-1332	628	13	type	type	NOUN
dti-1332	628	14	3	3	NUM
dti-1332	628	15	.	.	NOUN
dti-1332	628	16	postgrad	postgrad	PROPN
dti-1332	628	17	.	.	PUNCT
dti-1332	629	1	med	med	PROPN
dti-1332	629	2	.	.	PUNCT
dti-1332	630	1	j.	j.	PROPN
dti-1332	630	2	,	,	PUNCT
dti-1332	630	3	80:363–5	80:363–5	NUM
dti-1332	630	4	.	.	PUNCT
dti-1332	631	1	napoli	napoli	PROPN
dti-1332	631	2	,	,	PUNCT
dti-1332	631	3	c.	c.	PROPN
dti-1332	631	4	,	,	PUNCT
dti-1332	631	5	lemieux	lemieux	PROPN
dti-1332	631	6	,	,	PUNCT
dti-1332	631	7	c.	c.	PROPN
dti-1332	631	8	and	and	CCONJ
dti-1332	631	9	jorgensen	jorgensen	PROPN
dti-1332	631	10	,	,	PUNCT
dti-1332	631	11	r.	r.	PROPN
dti-1332	631	12	1990	1990	NUM
dti-1332	631	13	.	.	PUNCT
dti-1332	632	1	introduction	introduction	NOUN
dti-1332	632	2	of	of	ADP
dti-1332	632	3	a	a	DET
dti-1332	632	4	chalcone	chalcone	NOUN
dti-1332	632	5	synthase	synthase	NOUN
dti-1332	632	6	gene	gene	NOUN
dti-1332	632	7	into	into	ADP
dti-1332	632	8	petunia	petunia	NOUN
dti-1332	632	9	results	result	NOUN
dti-1332	632	10	in	in	ADP
dti-1332	632	11	reversible	reversible	ADJ
dti-1332	632	12	cosuppression	cosuppression	NOUN
dti-1332	632	13	of	of	ADP
dti-1332	632	14	homologous	homologous	ADJ
dti-1332	632	15	genes	gene	NOUN
dti-1332	632	16	in	in	ADP
dti-1332	632	17	trans	tran	NOUN
dti-1332	632	18	.	.	PUNCT
dti-1332	633	1	plant	plant	NOUN
dti-1332	633	2	cell	cell	NOUN
dti-1332	633	3	.	.	PUNCT
dti-1332	634	1	,	,	PUNCT
dti-1332	634	2	2:279–89	2:279–89	X
dti-1332	634	3	.	.	PUNCT
dti-1332	635	1	neradovic	neradovic	PROPN
dti-1332	635	2	,	,	PUNCT
dti-1332	635	3	d.	d.	PROPN
dti-1332	635	4	,	,	PUNCT
dti-1332	635	5	soga	soga	PROPN
dti-1332	635	6	,	,	PUNCT
dti-1332	635	7	o.	o.	PROPN
dti-1332	635	8	,	,	PUNCT
dti-1332	635	9	van	van	PROPN
dti-1332	635	10	nostrum	nostrum	PROPN
dti-1332	635	11	,	,	PUNCT
dti-1332	635	12	c.f	c.f	PROPN
dti-1332	635	13	.	.	PROPN
dti-1332	635	14	et	et	PROPN
dti-1332	635	15	al	al	PROPN
dti-1332	635	16	.	.	PROPN
dti-1332	635	17	2004	2004	NUM
dti-1332	635	18	.	.	PUNCT
dti-1332	636	1	the	the	DET
dti-1332	636	2	effect	effect	NOUN
dti-1332	636	3	of	of	ADP
dti-1332	636	4	the	the	DET
dti-1332	636	5	processing	processing	NOUN
dti-1332	636	6	and	and	CCONJ
dti-1332	636	7	formulation	formulation	NOUN
dti-1332	636	8	parameters	parameter	NOUN
dti-1332	636	9	on	on	ADP
dti-1332	636	10	the	the	DET
dti-1332	636	11	size	size	NOUN
dti-1332	636	12	of	of	ADP
dti-1332	636	13	nanoparticles	nanoparticle	NOUN
dti-1332	636	14	based	base	VERB
dti-1332	636	15	on	on	ADP
dti-1332	636	16	block	block	NOUN
dti-1332	636	17	copolymers	copolymer	NOUN
dti-1332	636	18	of	of	ADP
dti-1332	636	19	poly(ethylene	poly(ethylene	ADJ
dti-1332	636	20	glycol	glycol	NOUN
dti-1332	636	21	)	)	PUNCT
dti-1332	636	22	and	and	CCONJ
dti-1332	636	23	poly(niso	poly(niso	PROPN
dti-1332	636	24	propylacrylamide	propylacrylamide	NOUN
dti-1332	636	25	)	)	PUNCT
dti-1332	636	26	with	with	ADP
dti-1332	636	27	and	and	CCONJ
dti-1332	636	28	without	without	ADP
dti-1332	636	29	hydrolytically	hydrolytically	ADV
dti-1332	636	30	sensitive	sensitive	ADJ
dti-1332	636	31	groups	group	NOUN
dti-1332	636	32	.	.	PUNCT
dti-1332	637	1	biomaterials	biomaterial	NOUN
dti-1332	637	2	,	,	PUNCT
dti-1332	637	3	25:2409–18	25:2409–18	NUM
dti-1332	637	4	.	.	PUNCT
dti-1332	638	1	o’hearn	o’hearn	PROPN
dti-1332	638	2	,	,	PUNCT
dti-1332	638	3	e.	e.	PROPN
dti-1332	638	4	,	,	PUNCT
dti-1332	638	5	holmes	holmes	PROPN
dti-1332	638	6	,	,	PUNCT
dti-1332	638	7	s.e	s.e	PROPN
dti-1332	638	8	.	.	PROPN
dti-1332	638	9	,	,	PUNCT
dti-1332	638	10	calvert	calvert	PROPN
dti-1332	638	11	,	,	PUNCT
dti-1332	638	12	p.c	p.c	PROPN
dti-1332	638	13	.	.	PROPN
dti-1332	638	14	et	et	PROPN
dti-1332	638	15	al	al	PROPN
dti-1332	638	16	.	.	PROPN
dti-1332	638	17	2001	2001	NUM
dti-1332	638	18	.	.	PUNCT
dti-1332	639	1	sca-12	sca-12	NOUN
dti-1332	639	2	:	:	PUNCT
dti-1332	639	3	tremor	tremor	NOUN
dti-1332	639	4	with	with	ADP
dti-1332	639	5	cerebellar	cerebellar	ADJ
dti-1332	639	6	and	and	CCONJ
dti-1332	639	7	cortical	cortical	ADJ
dti-1332	639	8	atrophy	atrophy	NOUN
dti-1332	639	9	is	be	AUX
dti-1332	639	10	associated	associate	VERB
dti-1332	639	11	with	with	ADP
dti-1332	639	12	a	a	DET
dti-1332	639	13	cag	cag	PROPN
dti-1332	639	14	repeat	repeat	PROPN
dti-1332	639	15	expansion	expansion	NOUN
dti-1332	639	16	.	.	PUNCT
dti-1332	640	1	neurology	neurology	NOUN
dti-1332	640	2	,	,	PUNCT
dti-1332	640	3	56:299–303	56:299–303	PROPN
dti-1332	640	4	.	.	PUNCT
dti-1332	641	1	oupicky	oupicky	PROPN
dti-1332	641	2	,	,	PUNCT
dti-1332	641	3	d.	d.	PROPN
dti-1332	641	4	,	,	PUNCT
dti-1332	641	5	ogris	ogris	PROPN
dti-1332	641	6	,	,	PUNCT
dti-1332	641	7	m.	m.	NOUN
dti-1332	641	8	,	,	PUNCT
dti-1332	641	9	howard	howard	PROPN
dti-1332	641	10	,	,	PUNCT
dti-1332	641	11	k.a	k.a	PROPN
dti-1332	641	12	.	.	PROPN
dti-1332	641	13	et	et	PROPN
dti-1332	642	1	al	al	PROPN
dti-1332	642	2	.	.	PROPN
dti-1332	642	3	2002	2002	NUM
dti-1332	642	4	.	.	PUNCT
dti-1332	643	1	importance	importance	NOUN
dti-1332	643	2	of	of	ADP
dti-1332	643	3	lateral	lateral	ADJ
dti-1332	643	4	and	and	CCONJ
dti-1332	643	5	steric	steric	ADJ
dti-1332	643	6	stabilization	stabilization	NOUN
dti-1332	643	7	of	of	ADP
dti-1332	643	8	polyelectrolyte	polyelectrolyte	ADJ
dti-1332	643	9	gene	gene	NOUN
dti-1332	643	10	delivery	delivery	NOUN
dti-1332	643	11	vectors	vector	NOUN
dti-1332	643	12	for	for	ADP
dti-1332	643	13	extended	extended	ADJ
dti-1332	643	14	systemic	systemic	ADJ
dti-1332	643	15	circulation	circulation	NOUN
dti-1332	643	16	.	.	PUNCT
dti-1332	644	1	mol	mol	PROPN
dti-1332	644	2	.	.	PROPN
dti-1332	645	1	ther	ther	PROPN
dti-1332	645	2	.	.	PUNCT
dti-1332	645	3	,	,	PUNCT
dti-1332	646	1	5:463–72	5:463–72	PROPN
dti-1332	646	2	.	.	PUNCT
dti-1332	647	1	paddison	paddison	PROPN
dti-1332	647	2	,	,	PUNCT
dti-1332	647	3	p.j	p.j	PROPN
dti-1332	647	4	.	.	PROPN
dti-1332	647	5	,	,	PUNCT
dti-1332	647	6	caudy	caudy	PROPN
dti-1332	647	7	,	,	PUNCT
dti-1332	647	8	a.a	a.a	PROPN
dti-1332	647	9	.	.	PROPN
dti-1332	647	10	,	,	PUNCT
dti-1332	647	11	sachidanandam	sachidanandam	PROPN
dti-1332	647	12	,	,	PUNCT
dti-1332	647	13	r.	r.	PROPN
dti-1332	647	14	et	et	PROPN
dti-1332	647	15	al	al	PROPN
dti-1332	647	16	.	.	PROPN
dti-1332	647	17	2004	2004	NUM
dti-1332	647	18	.	.	PUNCT
dti-1332	648	1	short	short	ADJ
dti-1332	648	2	hairpin	hairpin	ADJ
dti-1332	648	3	activated	activated	ADJ
dti-1332	648	4	gene	gene	NOUN
dti-1332	648	5	silencing	silence	VERB
dti-1332	648	6	in	in	ADP
dti-1332	648	7	mammalian	mammalian	ADJ
dti-1332	648	8	cells	cell	NOUN
dti-1332	648	9	.	.	PUNCT
dti-1332	649	1	methods	method	NOUN
dti-1332	649	2	mol	mol	PROPN
dti-1332	649	3	.	.	PUNCT
dti-1332	650	1	biol	biol	PROPN
dti-1332	650	2	.	.	PUNCT
dti-1332	650	3	,	,	PUNCT
dti-1332	651	1	265:85–100	265:85–100	NUM
dti-1332	651	2	.	.	PUNCT
dti-1332	651	3	palop	palop	PROPN
dti-1332	651	4	,	,	PUNCT
dti-1332	651	5	j.j	j.j	PROPN
dti-1332	651	6	.	.	PROPN
dti-1332	651	7	,	,	PUNCT
dti-1332	651	8	chin	chin	PROPN
dti-1332	651	9	,	,	PUNCT
dti-1332	651	10	j.	j.	PROPN
dti-1332	651	11	and	and	CCONJ
dti-1332	651	12	mucke	mucke	PROPN
dti-1332	651	13	,	,	PUNCT
dti-1332	651	14	l.	l.	PROPN
dti-1332	651	15	2006	2006	NUM
dti-1332	651	16	.	.	PUNCT
dti-1332	652	1	a	a	DET
dti-1332	652	2	network	network	NOUN
dti-1332	652	3	dysfunction	dysfunction	NOUN
dti-1332	652	4	perspective	perspective	NOUN
dti-1332	652	5	on	on	ADP
dti-1332	652	6	neurodegenerative	neurodegenerative	ADJ
dti-1332	652	7	diseases	disease	NOUN
dti-1332	652	8	.	.	PUNCT
dti-1332	653	1	nature	nature	NOUN
dti-1332	653	2	,	,	PUNCT
dti-1332	653	3	443:768–72	443:768–72	NUM
dti-1332	653	4	.	.	PUNCT
dti-1332	654	1	park	park	NOUN
dti-1332	654	2	,	,	PUNCT
dti-1332	654	3	y.	y.	PROPN
dti-1332	654	4	,	,	PUNCT
dti-1332	654	5	kwok	kwok	PROPN
dti-1332	654	6	,	,	PUNCT
dti-1332	654	7	k.y	k.y	PROPN
dti-1332	654	8	.	.	PROPN
dti-1332	654	9	,	,	PUNCT
dti-1332	654	10	boukarim	boukarim	PROPN
dti-1332	654	11	,	,	PUNCT
dti-1332	654	12	c.	c.	PROPN
dti-1332	654	13	et	et	PROPN
dti-1332	654	14	al	al	PROPN
dti-1332	654	15	.	.	PROPN
dti-1332	654	16	2002	2002	NUM
dti-1332	654	17	.	.	PUNCT
dti-1332	655	1	synthesis	synthesis	NOUN
dti-1332	655	2	of	of	ADP
dti-1332	655	3	sulfhydryl	sulfhydryl	PROPN
dti-1332	655	4	cross	cross	ADJ
dti-1332	655	5	-	-	ADJ
dti-1332	655	6	linking	link	VERB
dti-1332	655	7	poly(ethylene	poly(ethylene	ADJ
dti-1332	655	8	glycol)-peptides	glycol)-peptide	NOUN
dti-1332	655	9	and	and	CCONJ
dti-1332	655	10	glycopeptides	glycopeptide	VERB
dti-1332	655	11	as	as	ADP
dti-1332	655	12	carriers	carrier	NOUN
dti-1332	655	13	for	for	ADP
dti-1332	655	14	gene	gene	NOUN
dti-1332	655	15	delivery	delivery	NOUN
dti-1332	655	16	.	.	PUNCT
dti-1332	656	1	bioconjug	bioconjug	NOUN
dti-1332	656	2	.	.	PUNCT
dti-1332	657	1	chem	chem	PROPN
dti-1332	657	2	.	.	PUNCT
dti-1332	657	3	,	,	PUNCT
dti-1332	658	1	13:232–9	13:232–9	NUM
dti-1332	658	2	.	.	PUNCT
dti-1332	658	3	park	park	NOUN
dti-1332	658	4	,	,	PUNCT
dti-1332	658	5	y.	y.	PROPN
dti-1332	658	6	,	,	PUNCT
dti-1332	658	7	hong	hong	PROPN
dti-1332	658	8	,	,	PUNCT
dti-1332	658	9	s.	s.	PROPN
dti-1332	658	10	,	,	PUNCT
dti-1332	658	11	kim	kim	PROPN
dti-1332	658	12	,	,	PUNCT
dti-1332	658	13	s.j	s.j	PROPN
dti-1332	658	14	.	.	PROPN
dti-1332	658	15	et	et	PROPN
dti-1332	658	16	al	al	PROPN
dti-1332	658	17	.	.	PROPN
dti-1332	658	18	2005	2005	NUM
dti-1332	658	19	.	.	PUNCT
dti-1332	659	1	proteasome	proteasome	NOUN
dti-1332	659	2	function	function	NOUN
dti-1332	659	3	is	be	AUX
dti-1332	659	4	inhibited	inhibit	VERB
dti-1332	659	5	by	by	ADP
dti-1332	659	6	polyglutamine	polyglutamine	NOUN
dti-1332	659	7	-	-	PUNCT
dti-1332	659	8	expanded	expand	VERB
dti-1332	659	9	ataxin-1	ataxin-1	PROPN
dti-1332	659	10	,	,	PUNCT
dti-1332	659	11	the	the	DET
dti-1332	659	12	sca1	sca1	NOUN
dti-1332	659	13	gene	gene	NOUN
dti-1332	659	14	product	product	NOUN
dti-1332	659	15	.	.	PUNCT
dti-1332	660	1	mol	mol	PROPN
dti-1332	660	2	.	.	PUNCT
dti-1332	661	1	cells	cell	NOUN
dti-1332	661	2	,	,	PUNCT
dti-1332	661	3	19:23–30	19:23–30	NUM
dti-1332	661	4	.	.	PUNCT
dti-1332	662	1	peden	peden	PROPN
dti-1332	662	2	,	,	PUNCT
dti-1332	662	3	c.s	c.s	PROPN
dti-1332	662	4	.	.	PROPN
dti-1332	662	5	,	,	PUNCT
dti-1332	662	6	burger	burger	NOUN
dti-1332	662	7	,	,	PUNCT
dti-1332	662	8	c.	c.	PROPN
dti-1332	662	9	,	,	PUNCT
dti-1332	662	10	muzyczka	muzyczka	NOUN
dti-1332	662	11	,	,	PUNCT
dti-1332	662	12	n.	n.	PROPN
dti-1332	662	13	et	et	PROPN
dti-1332	662	14	al	al	PROPN
dti-1332	662	15	.	.	PROPN
dti-1332	662	16	2004	2004	NUM
dti-1332	662	17	.	.	PUNCT
dti-1332	663	1	circulating	circulate	VERB
dti-1332	663	2	anti	anti	ADJ
dti-1332	663	3	wild	wild	ADJ
dti-1332	663	4	type	type	NOUN
dti-1332	663	5	adeno	adeno	NOUN
dti-1332	663	6	associated	associate	VERB
dti-1332	663	7	virus	virus	NOUN
dti-1332	663	8	type	type	NOUN
dti-1332	663	9	2	2	NUM
dti-1332	663	10	(	(	PUNCT
dti-1332	663	11	aav2	aav2	PROPN
dti-1332	663	12	antibodies	antibodie	VERB
dti-1332	663	13	inhibit	inhibit	VERB
dti-1332	663	14	recombinant	recombinant	ADJ
dti-1332	663	15	aav2	aav2	NOUN
dti-1332	663	16	(	(	PUNCT
dti-1332	663	17	raav2)-mediated	raav2)-mediate	VERB
dti-1332	663	18	,	,	PUNCT
dti-1332	663	19	but	but	CCONJ
dti-1332	663	20	not	not	PART
dti-1332	663	21	raav5	raav5	NOUN
dti-1332	663	22	mediated	mediate	VERB
dti-1332	663	23	,	,	PUNCT
dti-1332	663	24	gene	gene	NOUN
dti-1332	663	25	transfer	transfer	NOUN
dti-1332	663	26	in	in	ADP
dti-1332	663	27	the	the	DET
dti-1332	663	28	brain	brain	NOUN
dti-1332	663	29	.	.	PUNCT
dti-1332	664	1	j.	j.	PROPN
dti-1332	664	2	virol	virol	PROPN
dti-1332	664	3	.	.	PUNCT
dti-1332	664	4	,	,	PUNCT
dti-1332	664	5	78:6344–59	78:6344–59	NUM
dti-1332	664	6	.	.	PUNCT
dti-1332	665	1	perutz	perutz	ADJ
dti-1332	665	2	,	,	PUNCT
dti-1332	665	3	m.	m.	NOUN
dti-1332	665	4	1994	1994	NUM
dti-1332	665	5	.	.	PUNCT
dti-1332	666	1	protein	protein	NOUN
dti-1332	666	2	science	science	NOUN
dti-1332	666	3	(	(	PUNCT
dti-1332	666	4	cambridge	cambridge	PROPN
dti-1332	666	5	univ	univ	PROPN
dti-1332	666	6	.	.	PUNCT
dti-1332	667	1	press	press	PROPN
dti-1332	667	2	,	,	PUNCT
dti-1332	667	3	london	london	PROPN
dti-1332	667	4	)	)	PUNCT
dti-1332	667	5	1629–37	1629–37	NOUN
dti-1332	667	6	.	.	PUNCT
dti-1332	668	1	perutz	perutz	ADJ
dti-1332	668	2	,	,	PUNCT
dti-1332	668	3	m.f	m.f	PROPN
dti-1332	668	4	.	.	PROPN
dti-1332	668	5	1999	1999	NUM
dti-1332	668	6	.	.	PUNCT
dti-1332	669	1	glutamine	glutamine	PROPN
dti-1332	669	2	repeats	repeat	NOUN
dti-1332	669	3	and	and	CCONJ
dti-1332	669	4	neurodegenerative	neurodegenerative	ADJ
dti-1332	669	5	diseases	disease	NOUN
dti-1332	669	6	.	.	PUNCT
dti-1332	670	1	brain	brain	NOUN
dti-1332	670	2	res	re	NOUN
dti-1332	670	3	.	.	PUNCT
dti-1332	671	1	bull	bull	NOUN
dti-1332	671	2	,	,	PUNCT
dti-1332	671	3	50:467	50:467	NUM
dti-1332	671	4	.	.	PUNCT
dti-1332	672	1	pirker	pirker	PROPN
dti-1332	672	2	,	,	PUNCT
dti-1332	672	3	w.	w.	PROPN
dti-1332	672	4	,	,	PUNCT
dti-1332	672	5	back	back	ADV
dti-1332	672	6	,	,	PUNCT
dti-1332	672	7	c.	c.	NOUN
dti-1332	672	8	,	,	PUNCT
dti-1332	672	9	gerschlager	gerschlager	NOUN
dti-1332	672	10	,	,	PUNCT
dti-1332	672	11	w.	w.	PROPN
dti-1332	672	12	et	et	PROPN
dti-1332	672	13	al	al	PROPN
dti-1332	672	14	.	.	PROPN
dti-1332	672	15	2003	2003	NUM
dti-1332	672	16	.	.	PUNCT
dti-1332	673	1	chronic	chronic	ADJ
dti-1332	673	2	thalamic	thalamic	ADJ
dti-1332	673	3	stimulation	stimulation	NOUN
dti-1332	673	4	in	in	ADP
dti-1332	673	5	a	a	DET
dti-1332	673	6	patient	patient	NOUN
dti-1332	673	7	with	with	ADP
dti-1332	673	8	spinocerebellar	spinocerebellar	ADJ
dti-1332	673	9	ataxia	ataxia	NOUN
dti-1332	673	10	type	type	NOUN
dti-1332	673	11	2	2	NUM
dti-1332	673	12	.	.	PUNCT
dti-1332	673	13	mov	mov	NOUN
dti-1332	673	14	.	.	PUNCT
dti-1332	674	1	disord	disord	PROPN
dti-1332	674	2	.	.	PUNCT
dti-1332	674	3	,	,	PUNCT
dti-1332	674	4	18:222–5	18:222–5	NUM
dti-1332	674	5	.	.	PUNCT
dti-1332	675	1	poirier	poirier	PROPN
dti-1332	675	2	,	,	PUNCT
dti-1332	675	3	m.a	m.a	PROPN
dti-1332	675	4	.	.	PROPN
dti-1332	675	5	,	,	PUNCT
dti-1332	675	6	li	li	PROPN
dti-1332	675	7	,	,	PUNCT
dti-1332	675	8	h.	h.	PROPN
dti-1332	675	9	,	,	PUNCT
dti-1332	675	10	macosko	macosko	PROPN
dti-1332	675	11	,	,	PUNCT
dti-1332	675	12	j.	j.	PROPN
dti-1332	675	13	et	et	PROPN
dti-1332	675	14	al	al	PROPN
dti-1332	675	15	.	.	PROPN
dti-1332	675	16	2002	2002	NUM
dti-1332	675	17	.	.	PUNCT
dti-1332	676	1	huntingtin	huntingtin	PROPN
dti-1332	676	2	spheroids	spheroid	NOUN
dti-1332	676	3	and	and	CCONJ
dti-1332	676	4	protofi	protofi	ADJ
dti-1332	676	5	brils	bril	NOUN
dti-1332	676	6	as	as	ADP
dti-1332	676	7	precursors	precursor	NOUN
dti-1332	676	8	in	in	ADP
dti-1332	676	9	polyglutamine	polyglutamine	PROPN
dti-1332	676	10	fibrilization	fibrilization	NOUN
dti-1332	676	11	.	.	PUNCT
dti-1332	677	1	j.	j.	PROPN
dti-1332	677	2	biol	biol	PROPN
dti-1332	677	3	.	.	PUNCT
dti-1332	678	1	chem	chem	PROPN
dti-1332	678	2	.	.	PUNCT
dti-1332	678	3	,	,	PUNCT
dti-1332	679	1	277:41032–7	277:41032–7	X
dti-1332	679	2	.	.	PUNCT
dti-1332	680	1	ralph	ralph	PROPN
dti-1332	680	2	,	,	PUNCT
dti-1332	680	3	g.s	g.s	PROPN
dti-1332	680	4	.	.	PROPN
dti-1332	680	5	,	,	PUNCT
dti-1332	680	6	radcliffe	radcliffe	PROPN
dti-1332	680	7	,	,	PUNCT
dti-1332	680	8	p.a	p.a	PROPN
dti-1332	680	9	.	.	PROPN
dti-1332	680	10	,	,	PUNCT
dti-1332	680	11	day	day	PROPN
dti-1332	680	12	,	,	PUNCT
dti-1332	680	13	d.m	d.m	PROPN
dti-1332	680	14	.	.	PROPN
dti-1332	680	15	et	et	PROPN
dti-1332	680	16	al	al	PROPN
dti-1332	680	17	.	.	PROPN
dti-1332	680	18	2005	2005	NUM
dti-1332	680	19	.	.	PUNCT
dti-1332	681	1	silencing	silence	VERB
dti-1332	681	2	mutant	mutant	ADJ
dti-1332	681	3	sod1	sod1	NOUN
dti-1332	681	4	using	use	VERB
dti-1332	681	5	rnai	rnai	NOUN
dti-1332	681	6	protects	protect	NOUN
dti-1332	681	7	against	against	ADP
dti-1332	681	8	neurodegeneration	neurodegeneration	NOUN
dti-1332	681	9	and	and	CCONJ
dti-1332	681	10	exytends	exytend	VERB
dti-1332	681	11	survival	survival	NOUN
dti-1332	681	12	in	in	ADP
dti-1332	681	13	an	an	DET
dti-1332	681	14	als	als	NOUN
dti-1332	681	15	model	model	NOUN
dti-1332	681	16	.	.	PUNCT
dti-1332	682	1	nature	nature	NOUN
dti-1332	682	2	medicine	medicine	PROPN
dti-1332	682	3	,	,	PUNCT
dti-1332	682	4	11:429–33	11:429–33	PROPN
dti-1332	682	5	.	.	PUNCT
dti-1332	683	1	ranum	ranum	ADJ
dti-1332	683	2	,	,	PUNCT
dti-1332	683	3	l.p	l.p	PROPN
dti-1332	683	4	.	.	PROPN
dti-1332	683	5	,	,	PUNCT
dti-1332	683	6	schut	schut	PROPN
dti-1332	683	7	,	,	PUNCT
dti-1332	683	8	l.j	l.j	PROPN
dti-1332	683	9	.	.	PROPN
dti-1332	683	10	,	,	PUNCT
dti-1332	683	11	lundgren	lundgren	PROPN
dti-1332	683	12	,	,	PUNCT
dti-1332	683	13	j.k	j.k	PROPN
dti-1332	683	14	.	.	PROPN
dti-1332	683	15	et	et	PROPN
dti-1332	684	1	al	al	PROPN
dti-1332	684	2	.	.	PROPN
dti-1332	684	3	1994	1994	NUM
dti-1332	684	4	.	.	PUNCT
dti-1332	685	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	685	2	ataxia	ataxia	NOUN
dti-1332	685	3	type	type	NOUN
dti-1332	685	4	5	5	NUM
dti-1332	685	5	in	in	ADP
dti-1332	685	6	a	a	DET
dti-1332	685	7	family	family	NOUN
dti-1332	685	8	descended	descend	VERB
dti-1332	685	9	from	from	ADP
dti-1332	685	10	the	the	DET
dti-1332	685	11	grandparents	grandparent	NOUN
dti-1332	685	12	of	of	ADP
dti-1332	685	13	president	president	PROPN
dti-1332	685	14	lincoln	lincoln	PROPN
dti-1332	685	15	maps	map	NOUN
dti-1332	685	16	to	to	PART
dti-1332	685	17	chromosome	chromosome	VERB
dti-1332	685	18	11	11	NUM
dti-1332	685	19	.	.	PUNCT
dti-1332	686	1	nat	nat	PROPN
dti-1332	686	2	.	.	PUNCT
dti-1332	687	1	genet	genet	PROPN
dti-1332	687	2	.	.	PUNCT
dti-1332	687	3	,	,	PUNCT
dti-1332	688	1	8:280–4	8:280–4	X
dti-1332	688	2	.	.	PUNCT
dti-1332	689	1	raoul	raoul	PROPN
dti-1332	689	2	,	,	PUNCT
dti-1332	689	3	c.	c.	PROPN
dti-1332	689	4	,	,	PUNCT
dti-1332	689	5	abbas	abbas	NOUN
dti-1332	689	6	-	-	PUNCT
dti-1332	689	7	terki	terki	NOUN
dti-1332	689	8	,	,	PUNCT
dti-1332	689	9	t.	t.	PROPN
dti-1332	689	10	,	,	PUNCT
dti-1332	689	11	bensadoun	bensadoun	PROPN
dti-1332	689	12	,	,	PUNCT
dti-1332	689	13	j.c	j.c	PROPN
dti-1332	689	14	.	.	PROPN
dti-1332	689	15	et	et	PROPN
dti-1332	689	16	al	al	PROPN
dti-1332	689	17	.	.	PROPN
dti-1332	689	18	2005	2005	NUM
dti-1332	689	19	.	.	PUNCT
dti-1332	690	1	lentiviral	lentiviral	ADJ
dti-1332	690	2	-	-	PUNCT
dti-1332	690	3	mediated	mediate	VERB
dti-1332	690	4	silencing	silencing	NOUN
dti-1332	690	5	of	of	ADP
dti-1332	690	6	sod1	sod1	NOUN
dti-1332	690	7	through	through	ADP
dti-1332	690	8	rna	rna	NOUN
dti-1332	690	9	interference	interference	NOUN
dti-1332	690	10	retards	retard	NOUN
dti-1332	690	11	disease	disease	NOUN
dti-1332	690	12	onset	onset	VERB
dti-1332	690	13	and	and	CCONJ
dti-1332	690	14	progression	progression	NOUN
dti-1332	690	15	in	in	ADP
dti-1332	690	16	a	a	DET
dti-1332	690	17	mouse	mouse	NOUN
dti-1332	690	18	model	model	NOUN
dti-1332	690	19	of	of	ADP
dti-1332	690	20	als	al	NOUN
dti-1332	690	21	.	.	PUNCT
dti-1332	691	1	nature	nature	NOUN
dti-1332	691	2	medicine	medicine	NOUN
dti-1332	691	3	,	,	PUNCT
dti-1332	691	4	11:423–8	11:423–8	NUM
dti-1332	691	5	.	.	PUNCT
dti-1332	692	1	reynolds	reynolds	PROPN
dti-1332	692	2	,	,	PUNCT
dti-1332	692	3	a.	a.	PROPN
dti-1332	692	4	,	,	PUNCT
dti-1332	692	5	leake	leake	PROPN
dti-1332	692	6	,	,	PUNCT
dti-1332	692	7	d.	d.	PROPN
dti-1332	692	8	,	,	PUNCT
dti-1332	692	9	boese	boese	PROPN
dti-1332	692	10	,	,	PUNCT
dti-1332	692	11	q.	q.	PROPN
dti-1332	692	12	et	et	PROPN
dti-1332	692	13	al	al	PROPN
dti-1332	692	14	.	.	PROPN
dti-1332	692	15	2004	2004	NUM
dti-1332	692	16	.	.	PUNCT
dti-1332	693	1	rational	rational	ADJ
dti-1332	693	2	sirna	sirna	PROPN
dti-1332	693	3	design	design	PROPN
dti-1332	693	4	for	for	ADP
dti-1332	693	5	rna	rna	NOUN
dti-1332	693	6	interference	interference	NOUN
dti-1332	693	7	.	.	PUNCT
dti-1332	694	1	nature	nature	NOUN
dti-1332	694	2	biotechnology	biotechnology	NOUN
dti-1332	694	3	,	,	PUNCT
dti-1332	694	4	22:326–30	22:326–30	PROPN
dti-1332	694	5	.	.	PUNCT
dti-1332	695	1	riess	riess	PROPN
dti-1332	695	2	,	,	PUNCT
dti-1332	695	3	o.	o.	PROPN
dti-1332	695	4	,	,	PUNCT
dti-1332	695	5	schöls	schöls	PROPN
dti-1332	695	6	,	,	PUNCT
dti-1332	695	7	l.	l.	PROPN
dti-1332	695	8	,	,	PUNCT
dti-1332	695	9	bottger	bottger	NOUN
dti-1332	695	10	,	,	PUNCT
dti-1332	695	11	h.	h.	PROPN
dti-1332	695	12	et	et	PROPN
dti-1332	695	13	al	al	PROPN
dti-1332	695	14	.	.	PROPN
dti-1332	695	15	1997	1997	NUM
dti-1332	695	16	.	.	PUNCT
dti-1332	696	1	sca6	sca6	PROPN
dti-1332	696	2	is	be	AUX
dti-1332	696	3	caused	cause	VERB
dti-1332	696	4	by	by	ADP
dti-1332	696	5	moderate	moderate	ADJ
dti-1332	696	6	cag	cag	PROPN
dti-1332	696	7	expansion	expansion	NOUN
dti-1332	696	8	in	in	ADP
dti-1332	696	9	the	the	DET
dti-1332	696	10	alpha1a	alpha1a	NOUN
dti-1332	696	11	-	-	PUNCT
dti-1332	696	12	voltage	voltage	NOUN
dti-1332	696	13	-	-	PUNCT
dti-1332	696	14	dependent	dependent	ADJ
dti-1332	696	15	calcium	calcium	NOUN
dti-1332	696	16	channel	channel	NOUN
dti-1332	696	17	gene	gene	NOUN
dti-1332	696	18	.	.	PUNCT
dti-1332	697	1	hum	hum	PROPN
dti-1332	697	2	.	.	PUNCT
dti-1332	698	1	mol	mol	PROPN
dti-1332	698	2	.	.	PUNCT
dti-1332	698	3	genet	genet	PROPN
dti-1332	698	4	.	.	PUNCT
dti-1332	699	1	,	,	PUNCT
dti-1332	700	1	6:1289–93	6:1289–93	NUM
dti-1332	700	2	.	.	PUNCT
dti-1332	701	1	riley	riley	PROPN
dti-1332	701	2	,	,	PUNCT
dti-1332	701	3	m.g	m.g	PROPN
dti-1332	701	4	.	.	PROPN
dti-1332	701	5	,	,	PUNCT
dti-1332	701	6	kim	kim	PROPN
dti-1332	701	7	,	,	PUNCT
dti-1332	701	8	n.n	n.n	PROPN
dti-1332	701	9	.	.	PROPN
dti-1332	701	10	,	,	PUNCT
dti-1332	701	11	watson	watson	PROPN
dti-1332	701	12	,	,	PUNCT
dti-1332	701	13	v.e	v.e	PROPN
dti-1332	701	14	.	.	PROPN
dti-1332	701	15	et	et	PROPN
dti-1332	701	16	al	al	PROPN
dti-1332	701	17	.	.	PROPN
dti-1332	701	18	1998	1998	NUM
dti-1332	701	19	.	.	PUNCT
dti-1332	702	1	intra	intra	ADJ
dti-1332	702	2	-	-	ADJ
dti-1332	702	3	arterial	arterial	ADJ
dti-1332	702	4	administration	administration	NOUN
dti-1332	702	5	of	of	ADP
dti-1332	702	6	carboplatin	carboplatin	PROPN
dti-1332	702	7	and	and	CCONJ
dti-1332	702	8	the	the	DET
dti-1332	702	9	blood	blood	NOUN
dti-1332	702	10	brain	brain	NOUN
dti-1332	702	11	barrier	barrier	NOUN
dti-1332	702	12	permeabilizing	permeabilize	VERB
dti-1332	702	13	agent	agent	NOUN
dti-1332	702	14	,	,	PUNCT
dti-1332	702	15	rmp7	rmp7	NOUN
dti-1332	702	16	:	:	PUNCT
dti-1332	702	17	a	a	DET
dti-1332	702	18	toxicologic	toxicologic	ADJ
dti-1332	702	19	evaluation	evaluation	NOUN
dti-1332	702	20	in	in	ADP
dti-1332	702	21	swine	swine	PROPN
dti-1332	702	22	.	.	PUNCT
dti-1332	703	1	j.	j.	PROPN
dti-1332	703	2	neurooncol	neurooncol	PROPN
dti-1332	703	3	.	.	PROPN
dti-1332	703	4	,	,	PUNCT
dti-1332	703	5	36:167–78	36:167–78	PROPN
dti-1332	703	6	.	.	PUNCT
dti-1332	704	1	rodrigueze	rodrigueze	NOUN
dti-1332	704	2	-	-	PUNCT
dti-1332	704	3	lebron	lebron	PROPN
dti-1332	704	4	,	,	PUNCT
dti-1332	704	5	e.	e.	PROPN
dti-1332	704	6	and	and	CCONJ
dti-1332	704	7	gonzalez	gonzalez	PROPN
dti-1332	704	8	-	-	PUNCT
dti-1332	704	9	alegre	alegre	PROPN
dti-1332	704	10	,	,	PUNCT
dti-1332	704	11	p.g	p.g	PROPN
dti-1332	704	12	.	.	PROPN
dti-1332	704	13	2006	2006	NUM
dti-1332	704	14	.	.	PUNCT
dti-1332	705	1	silencing	silence	VERB
dti-1332	705	2	neurodegenerative	neurodegenerative	ADJ
dti-1332	705	3	disease	disease	NOUN
dti-1332	705	4	:	:	PUNCT
dti-1332	705	5	bringing	bring	VERB
dti-1332	705	6	rna	rna	NOUN
dti-1332	705	7	interference	interference	NOUN
dti-1332	705	8	to	to	ADP
dti-1332	705	9	the	the	DET
dti-1332	705	10	clinic	clinic	NOUN
dti-1332	705	11	.	.	PUNCT
dti-1332	706	1	expert	expert	PROPN
dti-1332	706	2	rev	rev	PROPN
dti-1332	706	3	.	.	PROPN
dti-1332	706	4	neurotherapeutics	neurotherapeutics	PROPN
dti-1332	706	5	,	,	PUNCT
dti-1332	707	1	6:223–33	6:223–33	PROPN
dti-1332	707	2	.	.	PUNCT
dti-1332	707	3	ross	ross	PROPN
dti-1332	707	4	,	,	PUNCT
dti-1332	707	5	c.a	c.a	PROPN
dti-1332	707	6	.	.	PROPN
dti-1332	707	7	,	,	PUNCT
dti-1332	707	8	poirier	poirier	PROPN
dti-1332	707	9	,	,	PUNCT
dti-1332	707	10	m.a	m.a	PROPN
dti-1332	707	11	.	.	PROPN
dti-1332	707	12	,	,	PUNCT
dti-1332	707	13	wanker	wanker	PROPN
dti-1332	707	14	,	,	PUNCT
dti-1332	707	15	e.e	e.e	PROPN
dti-1332	707	16	.	.	PROPN
dti-1332	707	17	et	et	PROPN
dti-1332	707	18	al	al	PROPN
dti-1332	707	19	.	.	PROPN
dti-1332	707	20	2003	2003	NUM
dti-1332	707	21	.	.	PUNCT
dti-1332	708	1	polyglutamine	polyglutamine	NOUN
dti-1332	708	2	fi	fi	NOUN
dti-1332	708	3	brillogenesis	brillogenesis	NOUN
dti-1332	708	4	:	:	PUNCT
dti-1332	708	5	the	the	DET
dti-1332	708	6	pathway	pathway	NOUN
dti-1332	708	7	unfolds	unfold	VERB
dti-1332	708	8	.	.	PUNCT
dti-1332	709	1	pnas	pna	NOUN
dti-1332	709	2	,	,	PUNCT
dti-1332	709	3	100:1–3	100:1–3	PROPN
dti-1332	709	4	.	.	PUNCT
dti-1332	710	1	rubinsztein	rubinsztein	PROPN
dti-1332	710	2	,	,	PUNCT
dti-1332	710	3	d.c	d.c	PROPN
dti-1332	710	4	.	.	PROPN
dti-1332	710	5	2006	2006	NUM
dti-1332	710	6	.	.	PUNCT
dti-1332	711	1	the	the	DET
dti-1332	711	2	roles	role	NOUN
dti-1332	711	3	of	of	ADP
dti-1332	711	4	intracellular	intracellular	ADJ
dti-1332	711	5	protein	protein	NOUN
dti-1332	711	6	-	-	PUNCT
dti-1332	711	7	degradation	degradation	NOUN
dti-1332	711	8	pathways	pathway	NOUN
dti-1332	711	9	in	in	ADP
dti-1332	711	10	neurodegeneration	neurodegeneration	NOUN
dti-1332	711	11	.	.	PUNCT
dti-1332	712	1	nature	nature	NOUN
dti-1332	712	2	,	,	PUNCT
dti-1332	712	3	443:780–6	443:780–6	PROPN
dti-1332	712	4	.	.	PUNCT
dti-1332	712	5	sah	sah	PROPN
dti-1332	712	6	,	,	PUNCT
dti-1332	712	7	dwy	dwy	NOUN
dti-1332	712	8	.	.	PUNCT
dti-1332	713	1	2006	2006	NUM
dti-1332	713	2	.	.	PUNCT
dti-1332	714	1	therapeutic	therapeutic	ADJ
dti-1332	714	2	potential	potential	NOUN
dti-1332	714	3	of	of	ADP
dti-1332	714	4	rna	rna	NOUN
dti-1332	714	5	interference	interference	NOUN
dti-1332	714	6	for	for	ADP
dti-1332	714	7	neurological	neurological	ADJ
dti-1332	714	8	disorders	disorder	NOUN
dti-1332	714	9	.	.	PUNCT
dti-1332	715	1	life	life	NOUN
dti-1332	715	2	sciences	sciences	PROPN
dti-1332	715	3	,	,	PUNCT
dti-1332	715	4	79:1773–80	79:1773–80	PROPN
dti-1332	715	5	.	.	PUNCT
dti-1332	715	6	sanovich	sanovich	PROPN
dti-1332	715	7	,	,	PUNCT
dti-1332	715	8	e.	e.	PROPN
dti-1332	715	9	,	,	PUNCT
dti-1332	715	10	bartus	bartus	PROPN
dti-1332	715	11	,	,	PUNCT
dti-1332	715	12	r.t	r.t	PROPN
dti-1332	715	13	.	.	PROPN
dti-1332	715	14	,	,	PUNCT
dti-1332	715	15	friden	friden	ADJ
dti-1332	715	16	,	,	PUNCT
dti-1332	715	17	p.m.	p.m.	NOUN
dti-1332	715	18	et	et	PROPN
dti-1332	715	19	al	al	PROPN
dti-1332	715	20	.	.	PROPN
dti-1332	715	21	1995	1995	NUM
dti-1332	715	22	.	.	PUNCT
dti-1332	716	1	pathway	pathway	NOUN
dti-1332	716	2	across	across	ADP
dti-1332	716	3	blood	blood	NOUN
dti-1332	716	4	-	-	PUNCT
dti-1332	716	5	brain	brain	NOUN
dti-1332	716	6	barrier	barrier	NOUN
dti-1332	716	7	opened	open	VERB
dti-1332	716	8	by	by	ADP
dti-1332	716	9	the	the	DET
dti-1332	716	10	bradykinin	bradykinin	PROPN
dti-1332	716	11	agonist	agonist	NOUN
dti-1332	716	12	,	,	PUNCT
dti-1332	716	13	rmp-7	rmp-7	X
dti-1332	716	14	.	.	PUNCT
dti-1332	717	1	brain	brain	NOUN
dti-1332	717	2	res	re	NOUN
dti-1332	717	3	.	.	PUNCT
dti-1332	717	4	,	,	PUNCT
dti-1332	717	5	705	705	NUM
dti-1332	717	6	.	.	PUNCT
dti-1332	717	7	schelhaas	schelhaas	NOUN
dti-1332	717	8	,	,	PUNCT
dti-1332	717	9	h.j	h.j	PROPN
dti-1332	717	10	.	.	PROPN
dti-1332	717	11	,	,	PUNCT
dti-1332	717	12	verbeek	verbeek	PROPN
dti-1332	717	13	,	,	PUNCT
dti-1332	717	14	d.s	d.s	PROPN
dti-1332	717	15	.	.	PROPN
dti-1332	717	16	,	,	PUNCT
dti-1332	717	17	van	van	PROPN
dti-1332	717	18	de	de	PROPN
dti-1332	717	19	warrenburg	warrenburg	PROPN
dti-1332	717	20	,	,	PUNCT
dti-1332	717	21	b.p	b.p	PROPN
dti-1332	717	22	.	.	PROPN
dti-1332	717	23	et	et	PROPN
dti-1332	717	24	al	al	PROPN
dti-1332	717	25	.	.	PROPN
dti-1332	717	26	2004	2004	NUM
dti-1332	717	27	.	.	PUNCT
dti-1332	718	1	sca19	sca19	VERB
dti-1332	718	2	and	and	CCONJ
dti-1332	718	3	sca22	sca22	PROPN
dti-1332	718	4	:	:	PUNCT
dti-1332	718	5	evidence	evidence	NOUN
dti-1332	718	6	for	for	ADP
dti-1332	718	7	one	one	NUM
dti-1332	718	8	locus	locus	NOUN
dti-1332	718	9	with	with	ADP
dti-1332	718	10	a	a	DET
dti-1332	718	11	worldwide	worldwide	ADJ
dti-1332	718	12	distribution	distribution	NOUN
dti-1332	718	13	.	.	PUNCT
dti-1332	719	1	brain	brain	NOUN
dti-1332	719	2	,	,	PUNCT
dti-1332	719	3	127	127	NUM
dti-1332	719	4	:	:	PUNCT
dti-1332	719	5	e6	e6	NOUN
dti-1332	719	6	.	.	PUNCT
dti-1332	720	1	schiffelers	schiffeler	NOUN
dti-1332	720	2	,	,	PUNCT
dti-1332	720	3	r.m	r.m	PROPN
dti-1332	720	4	.	.	PROPN
dti-1332	720	5	,	,	PUNCT
dti-1332	720	6	ansari	ansari	PROPN
dti-1332	720	7	,	,	PUNCT
dti-1332	720	8	a.	a.	PROPN
dti-1332	720	9	,	,	PUNCT
dti-1332	720	10	xu	xu	PROPN
dti-1332	720	11	,	,	PUNCT
dti-1332	720	12	j.	j.	PROPN
dti-1332	720	13	et	et	PROPN
dti-1332	720	14	al	al	PROPN
dti-1332	720	15	.	.	PROPN
dti-1332	720	16	2004	2004	NUM
dti-1332	720	17	.	.	PUNCT
dti-1332	721	1	cancer	cancer	PROPN
dti-1332	721	2	sirna	sirna	PROPN
dti-1332	721	3	therapy	therapy	NOUN
dti-1332	721	4	by	by	ADP
dti-1332	721	5	tumor	tumor	NOUN
dti-1332	721	6	selective	selective	ADJ
dti-1332	721	7	delivery	delivery	NOUN
dti-1332	721	8	with	with	ADP
dti-1332	721	9	ligand	ligand	NOUN
dti-1332	721	10	-	-	PUNCT
dti-1332	721	11	targeted	target	VERB
dti-1332	721	12	sterically	sterically	ADV
dti-1332	721	13	stabilized	stabilize	VERB
dti-1332	721	14	nanoparticle	nanoparticle	NOUN
dti-1332	721	15	.	.	PUNCT
dti-1332	722	1	nucleic	nucleic	ADJ
dti-1332	722	2	acids	acid	NOUN
dti-1332	722	3	res	re	NOUN
dti-1332	722	4	.	.	PUNCT
dti-1332	722	5	,	,	PUNCT
dti-1332	722	6	32	32	NUM
dti-1332	722	7	:	:	PUNCT
dti-1332	722	8	e149	e149	NUM
dti-1332	722	9	.	.	PUNCT
dti-1332	722	10	schiffelers	schiffeler	NOUN
dti-1332	722	11	,	,	PUNCT
dti-1332	722	12	r.m	r.m	PROPN
dti-1332	722	13	.	.	PROPN
dti-1332	722	14	,	,	PUNCT
dti-1332	722	15	mixson	mixson	PROPN
dti-1332	722	16	,	,	PUNCT
dti-1332	722	17	a.j	a.j	PROPN
dti-1332	722	18	.	.	PROPN
dti-1332	722	19	,	,	PUNCT
dti-1332	722	20	ansari	ansari	PROPN
dti-1332	722	21	,	,	PUNCT
dti-1332	722	22	a.m.	a.m.	PROPN
dti-1332	722	23	et	et	PROPN
dti-1332	722	24	al	al	PROPN
dti-1332	722	25	.	.	PROPN
dti-1332	722	26	2005	2005	NUM
dti-1332	722	27	.	.	PUNCT
dti-1332	723	1	transporting	transport	VERB
dti-1332	723	2	silence	silence	NOUN
dti-1332	723	3	:	:	PUNCT
dti-1332	723	4	design	design	NOUN
dti-1332	723	5	of	of	ADP
dti-1332	723	6	carriers	carrier	NOUN
dti-1332	723	7	for	for	SCONJ
dti-1332	723	8	sirna	sirna	PROPN
dti-1332	723	9	to	to	PART
dti-1332	723	10	angiogenic	angiogenic	VERB
dti-1332	723	11	endothelium	endothelium	NOUN
dti-1332	723	12	.	.	PUNCT
dti-1332	724	1	j.	j.	PROPN
dti-1332	724	2	controlled	control	VERB
dti-1332	724	3	release	release	PROPN
dti-1332	724	4	,	,	PUNCT
dti-1332	724	5	109:5–14	109:5–14	NUM
dti-1332	724	6	.	.	PUNCT
dti-1332	724	7	schwarz	schwarz	PROPN
dti-1332	724	8	,	,	PUNCT
dti-1332	724	9	d.s	d.s	PROPN
dti-1332	724	10	.	.	PROPN
dti-1332	724	11	,	,	PUNCT
dti-1332	724	12	ding	ding	NOUN
dti-1332	724	13	,	,	PUNCT
dti-1332	724	14	h.	h.	PROPN
dti-1332	724	15	,	,	PUNCT
dti-1332	724	16	kennington	kennington	PROPN
dti-1332	724	17	,	,	PUNCT
dti-1332	724	18	l.	l.	PROPN
dti-1332	724	19	et	et	PROPN
dti-1332	724	20	al	al	PROPN
dti-1332	724	21	.	.	PROPN
dti-1332	724	22	2006	2006	NUM
dti-1332	724	23	.	.	PUNCT
dti-1332	725	1	designing	design	VERB
dti-1332	725	2	sirna	sirna	PROPN
dti-1332	725	3	that	that	PRON
dti-1332	725	4	distinguish	distinguish	VERB
dti-1332	725	5	between	between	ADP
dti-1332	725	6	genes	gene	NOUN
dti-1332	725	7	that	that	PRON
dti-1332	725	8	differ	differ	VERB
dti-1332	725	9	by	by	ADP
dti-1332	725	10	a	a	DET
dti-1332	725	11	single	single	ADJ
dti-1332	725	12	nucleotide	nucleotide	NOUN
dti-1332	725	13	.	.	PUNCT
dti-1332	726	1	plos	plos	PROPN
dti-1332	726	2	genet	genet	PROPN
dti-1332	726	3	.	.	PROPN
dti-1332	726	4	,	,	PUNCT
dti-1332	726	5	2:1307–18	2:1307–18	NUM
dti-1332	726	6	.	.	PUNCT
dti-1332	727	1	singer	singer	NOUN
dti-1332	727	2	,	,	PUNCT
dti-1332	727	3	o.	o.	PROPN
dti-1332	727	4	,	,	PUNCT
dti-1332	727	5	marr	marr	PROPN
dti-1332	727	6	,	,	PUNCT
dti-1332	727	7	r.a	r.a	PROPN
dti-1332	727	8	.	.	PROPN
dti-1332	727	9	,	,	PUNCT
dti-1332	727	10	rockenstein	rockenstein	PROPN
dti-1332	727	11	,	,	PUNCT
dti-1332	727	12	e.	e.	PROPN
dti-1332	727	13	et	et	PROPN
dti-1332	727	14	al	al	PROPN
dti-1332	727	15	.	.	PROPN
dti-1332	727	16	2005	2005	NUM
dti-1332	727	17	.	.	PUNCT
dti-1332	728	1	targeting	target	VERB
dti-1332	728	2	bace	bace	PROPN
dti-1332	728	3	1	1	NUM
dti-1332	728	4	with	with	ADP
dti-1332	728	5	sirnas	sirna	NOUN
dti-1332	728	6	ameliorates	ameliorate	VERB
dti-1332	728	7	alzheimer	alzheimer	PROPN
dti-1332	728	8	disease	disease	PROPN
dti-1332	728	9	neuropathology	neuropathology	NOUN
dti-1332	728	10	in	in	ADP
dti-1332	728	11	a	a	DET
dti-1332	728	12	transgenic	transgenic	NOUN
dti-1332	728	13	model	model	NOUN
dti-1332	728	14	.	.	PUNCT
dti-1332	729	1	nature	nature	NOUN
dti-1332	729	2	neuroscience	neuroscience	PROPN
dti-1332	729	3	,	,	PUNCT
dti-1332	729	4	8:1343–9	8:1343–9	PROPN
dti-1332	729	5	.	.	PUNCT
dti-1332	730	1	sobczak	sobczak	PROPN
dti-1332	730	2	,	,	PUNCT
dti-1332	730	3	k.	k.	PROPN
dti-1332	730	4	and	and	CCONJ
dti-1332	730	5	krzyzosiak	krzyzosiak	PROPN
dti-1332	730	6	,	,	PUNCT
dti-1332	730	7	w.j	w.j	PROPN
dti-1332	730	8	.	.	PROPN
dti-1332	730	9	2005	2005	NUM
dti-1332	730	10	.	.	PUNCT
dti-1332	731	1	cag	cag	PROPN
dti-1332	731	2	repeats	repeat	VERB
dti-1332	731	3	containing	contain	VERB
dti-1332	731	4	caa	caa	NOUN
dti-1332	731	5	interruptions	interruption	NOUN
dti-1332	731	6	form	form	VERB
dti-1332	731	7	branched	branch	VERB
dti-1332	731	8	hairpin	hairpin	NOUN
dti-1332	731	9	structures	structure	NOUN
dti-1332	731	10	in	in	ADP
dti-1332	731	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	731	12	ataxia	ataxia	NOUN
dti-1332	731	13	type	type	NOUN
dti-1332	731	14	2	2	NUM
dti-1332	731	15	transcripts	transcript	NOUN
dti-1332	731	16	.	.	PUNCT
dti-1332	732	1	j.	j.	PROPN
dti-1332	732	2	biol	biol	PROPN
dti-1332	732	3	.	.	PUNCT
dti-1332	733	1	chem	chem	PROPN
dti-1332	733	2	.	.	PUNCT
dti-1332	733	3	,	,	PUNCT
dti-1332	733	4	280:3898–910	280:3898–910	NUM
dti-1332	733	5	.	.	PUNCT
dti-1332	734	1	stevanin	stevanin	PROPN
dti-1332	734	2	,	,	PUNCT
dti-1332	734	3	g.	g.	PROPN
dti-1332	734	4	,	,	PUNCT
dti-1332	734	5	bouslam	bouslam	PROPN
dti-1332	734	6	,	,	PUNCT
dti-1332	734	7	n.	n.	NOUN
dti-1332	734	8	,	,	PUNCT
dti-1332	734	9	ravaux	ravaux	NOUN
dti-1332	734	10	,	,	PUNCT
dti-1332	734	11	l.	l.	PROPN
dti-1332	734	12	et	et	PROPN
dti-1332	734	13	al	al	PROPN
dti-1332	734	14	.	.	PROPN
dti-1332	734	15	2003	2003	NUM
dti-1332	734	16	.	.	PUNCT
dti-1332	735	1	autosomal	autosomal	ADJ
dti-1332	735	2	dominant	dominant	ADJ
dti-1332	735	3	cerebellar	cerebellar	ADJ
dti-1332	735	4	ataxia	ataxia	NOUN
dti-1332	735	5	with	with	ADP
dti-1332	735	6	sensory	sensory	ADJ
dti-1332	735	7	neuropathy	neuropathy	ADJ
dti-1332	735	8	maps	map	NOUN
dti-1332	735	9	to	to	ADP
dti-1332	735	10	the	the	DET
dti-1332	735	11	spinocerebellar	spinocerebellar	ADJ
dti-1332	735	12	ataxia	ataxia	NOUN
dti-1332	735	13	25	25	NUM
dti-1332	735	14	(	(	PUNCT
dti-1332	735	15	sca25	sca25	NOUN
dti-1332	735	16	)	)	PUNCT
dti-1332	735	17	locus	locus	NOUN
dti-1332	735	18	on	on	ADP
dti-1332	735	19	chromosome	chromosome	NOUN
dti-1332	735	20	2p15	2p15	NOUN
dti-1332	735	21	-	-	SYM
dti-1332	735	22	p21	p21	NOUN
dti-1332	735	23	.	.	PUNCT
dti-1332	735	24	am	be	AUX
dti-1332	735	25	.	.	PUNCT
dti-1332	736	1	j.	j.	PROPN
dti-1332	736	2	hum	hum	PROPN
dti-1332	736	3	.	.	PUNCT
dti-1332	737	1	genet	genet	NOUN
dti-1332	737	2	.	.	PUNCT
dti-1332	738	1	,	,	PUNCT
dti-1332	738	2	73(suppl	73(suppl	NUM
dti-1332	738	3	1):2236	1):2236	NUM
dti-1332	738	4	.	.	PUNCT
dti-1332	738	5	storey	storey	PROPN
dti-1332	738	6	,	,	PUNCT
dti-1332	738	7	e.	e.	PROPN
dti-1332	738	8	,	,	PUNCT
dti-1332	738	9	gardner	gardner	PROPN
dti-1332	738	10	,	,	PUNCT
dti-1332	738	11	r.j	r.j	PROPN
dti-1332	738	12	.	.	PROPN
dti-1332	738	13	,	,	PUNCT
dti-1332	738	14	knight	knight	PROPN
dti-1332	738	15	,	,	PUNCT
dti-1332	738	16	m.a	m.a	PROPN
dti-1332	738	17	.	.	PROPN
dti-1332	738	18	et	et	PROPN
dti-1332	738	19	al	al	PROPN
dti-1332	738	20	.	.	PROPN
dti-1332	738	21	2001	2001	NUM
dti-1332	738	22	.	.	PUNCT
dti-1332	739	1	a	a	DET
dti-1332	739	2	new	new	ADJ
dti-1332	739	3	autosomal	autosomal	ADJ
dti-1332	739	4	dominant	dominant	ADJ
dti-1332	739	5	pure	pure	ADJ
dti-1332	739	6	cerebellar	cerebellar	ADJ
dti-1332	739	7	ataxia	ataxia	NOUN
dti-1332	739	8	.	.	PUNCT
dti-1332	740	1	neurology	neurology	NOUN
dti-1332	740	2	,	,	PUNCT
dti-1332	740	3	57:1913–5	57:1913–5	PROPN
dti-1332	740	4	.	.	PUNCT
dti-1332	740	5	szentkuti	szentkuti	PROPN
dti-1332	740	6	,	,	PUNCT
dti-1332	740	7	l.	l.	PROPN
dti-1332	740	8	1997	1997	NUM
dti-1332	740	9	.	.	PUNCT
dti-1332	741	1	light	light	ADJ
dti-1332	741	2	microscopical	microscopical	ADJ
dti-1332	741	3	observations	observation	NOUN
dti-1332	741	4	on	on	ADP
dti-1332	741	5	luminally	luminally	ADV
dti-1332	741	6	administered	administer	VERB
dti-1332	741	7	dyes	dye	NOUN
dti-1332	741	8	,	,	PUNCT
dti-1332	741	9	dextrans	dextran	NOUN
dti-1332	741	10	,	,	PUNCT
dti-1332	741	11	nanospheres	nanosphere	NOUN
dti-1332	741	12	and	and	CCONJ
dti-1332	741	13	microspheres	microsphere	NOUN
dti-1332	741	14	in	in	ADP
dti-1332	741	15	the	the	DET
dti-1332	741	16	preepithelial	preepithelial	ADJ
dti-1332	741	17	mucus	mucus	NOUN
dti-1332	741	18	gel	gel	NOUN
dti-1332	741	19	layer	layer	NOUN
dti-1332	741	20	of	of	ADP
dti-1332	741	21	the	the	DET
dti-1332	741	22	rat	rat	NOUN
dti-1332	741	23	distal	distal	ADJ
dti-1332	741	24	colon	colon	NOUN
dti-1332	741	25	.	.	PUNCT
dti-1332	742	1	j.	j.	PROPN
dti-1332	742	2	control	control	PROPN
dti-1332	742	3	release	release	PROPN
dti-1332	742	4	,	,	PUNCT
dti-1332	742	5	46:233–42	46:233–42	PROPN
dti-1332	742	6	.	.	PUNCT
dti-1332	743	1	thakker	thakker	PROPN
dti-1332	743	2	,	,	PUNCT
dti-1332	743	3	d.r	d.r	PROPN
dti-1332	743	4	.	.	PROPN
dti-1332	743	5	,	,	PUNCT
dti-1332	743	6	natt	natt	PROPN
dti-1332	743	7	,	,	PUNCT
dti-1332	743	8	f.	f.	PROPN
dti-1332	743	9	,	,	PUNCT
dti-1332	743	10	husken	husken	PROPN
dti-1332	743	11	,	,	PUNCT
dti-1332	743	12	d.	d.	PROPN
dti-1332	743	13	et	et	PROPN
dti-1332	743	14	al	al	PROPN
dti-1332	743	15	.	.	PROPN
dti-1332	743	16	2004	2004	NUM
dti-1332	743	17	.	.	PUNCT
dti-1332	744	1	neurochemical	neurochemical	ADJ
dti-1332	744	2	and	and	CCONJ
dti-1332	744	3	behavioural	behavioural	ADJ
dti-1332	744	4	consequences	consequence	NOUN
dti-1332	744	5	of	of	ADP
dti-1332	744	6	widespread	widespread	ADJ
dti-1332	744	7	gene	gene	NOUN
dti-1332	744	8	knockdown	knockdown	NOUN
dti-1332	744	9	in	in	ADP
dti-1332	744	10	the	the	DET
dti-1332	744	11	adult	adult	NOUN
dti-1332	744	12	mouse	mouse	NOUN
dti-1332	744	13	brain	brain	NOUN
dti-1332	744	14	by	by	ADP
dti-1332	744	15	using	use	VERB
dti-1332	744	16	non	non	ADJ
dti-1332	744	17	viral	viral	ADJ
dti-1332	744	18	rna	rna	NOUN
dti-1332	744	19	interference	interference	NOUN
dti-1332	744	20	.	.	PUNCT
dti-1332	745	1	proc	proc	PROPN
dti-1332	745	2	.	.	PUNCT
dti-1332	746	1	natl	natl	PROPN
dti-1332	746	2	.	.	PUNCT
dti-1332	747	1	acad	acad	PROPN
dti-1332	747	2	.	.	PUNCT
dti-1332	748	1	sci	sci	PROPN
dti-1332	748	2	.	.	PUNCT
dti-1332	748	3	u.s.a	u.s.a	PROPN
dti-1332	748	4	.	.	PROPN
dti-1332	748	5	,	,	PUNCT
dti-1332	748	6	101:17270–5	101:17270–5	PROPN
dti-1332	748	7	.	.	PUNCT
dti-1332	749	1	thakker	thakker	PROPN
dti-1332	749	2	,	,	PUNCT
dti-1332	749	3	d.r	d.r	PROPN
dti-1332	749	4	.	.	PROPN
dti-1332	749	5	,	,	PUNCT
dti-1332	749	6	natt	natt	PROPN
dti-1332	749	7	,	,	PUNCT
dti-1332	749	8	f.	f.	PROPN
dti-1332	749	9	,	,	PUNCT
dti-1332	749	10	husken	husken	PROPN
dti-1332	749	11	,	,	PUNCT
dti-1332	749	12	d.	d.	PROPN
dti-1332	749	13	et	et	PROPN
dti-1332	749	14	al	al	PROPN
dti-1332	749	15	.	.	PROPN
dti-1332	749	16	2005	2005	NUM
dti-1332	749	17	.	.	PUNCT
dti-1332	750	1	sirna	sirna	PROPN
dti-1332	750	2	–	–	PUNCT
dti-1332	750	3	mediated	mediate	VERB
dti-1332	750	4	knockdown	knockdown	NOUN
dti-1332	750	5	of	of	ADP
dti-1332	750	6	the	the	DET
dti-1332	750	7	serotonin	serotonin	NOUN
dti-1332	750	8	transporter	transporter	NOUN
dti-1332	750	9	in	in	ADP
dti-1332	750	10	the	the	DET
dti-1332	750	11	adult	adult	NOUN
dti-1332	750	12	mouse	mouse	NOUN
dti-1332	750	13	brain	brain	NOUN
dti-1332	750	14	.	.	PUNCT
dti-1332	751	1	molecular	molecular	ADJ
dti-1332	751	2	psychiatry	psychiatry	NOUN
dti-1332	751	3	,	,	PUNCT
dti-1332	751	4	10:782–9	10:782–9	NUM
dti-1332	751	5	.	.	PUNCT
dti-1332	752	1	thakker	thakker	PROPN
dti-1332	752	2	,	,	PUNCT
dti-1332	752	3	d.r	d.r	PROPN
dti-1332	752	4	.	.	PROPN
dti-1332	752	5	,	,	PUNCT
dti-1332	752	6	hoyer	hoyer	PROPN
dti-1332	752	7	,	,	PUNCT
dti-1332	752	8	d.	d.	PROPN
dti-1332	752	9	and	and	CCONJ
dti-1332	752	10	cryan	cryan	PROPN
dti-1332	752	11	,	,	PUNCT
dti-1332	752	12	j.f	j.f	PROPN
dti-1332	752	13	.	.	PROPN
dti-1332	752	14	2006	2006	NUM
dti-1332	752	15	.	.	PUNCT
dti-1332	753	1	interfering	interfere	VERB
dti-1332	753	2	with	with	ADP
dti-1332	753	3	the	the	DET
dti-1332	753	4	brain	brain	NOUN
dti-1332	753	5	:	:	PUNCT
dti-1332	753	6	use	use	NOUN
dti-1332	753	7	of	of	ADP
dti-1332	753	8	rna	rna	NOUN
dti-1332	753	9	interference	interference	NOUN
dti-1332	753	10	for	for	ADP
dti-1332	753	11	understanding	understand	VERB
dti-1332	753	12	the	the	DET
dti-1332	753	13	pathophysiologyof	pathophysiologyof	NOUN
dti-1332	753	14	psychiatric	psychiatric	ADJ
dti-1332	753	15	and	and	CCONJ
dti-1332	753	16	neurological	neurological	ADJ
dti-1332	753	17	disorders	disorder	NOUN
dti-1332	753	18	.	.	PUNCT
dti-1332	754	1	pharmacology	pharmacology	NOUN
dti-1332	754	2	and	and	CCONJ
dti-1332	754	3	therapeutics	therapeutic	NOUN
dti-1332	754	4	,	,	PUNCT
dti-1332	754	5	109:413–38	109:413–38	NUM
dti-1332	754	6	.	.	PUNCT
dti-1332	755	1	thakur	thakur	PROPN
dti-1332	755	2	,	,	PUNCT
dti-1332	755	3	a.k	a.k	PROPN
dti-1332	755	4	.	.	PROPN
dti-1332	755	5	and	and	CCONJ
dti-1332	755	6	wetzel	wetzel	PROPN
dti-1332	755	7	,	,	PUNCT
dti-1332	755	8	r.	r.	PROPN
dti-1332	755	9	2002	2002	NUM
dti-1332	755	10	.	.	PUNCT
dti-1332	756	1	mutational	mutational	ADJ
dti-1332	756	2	analysis	analysis	NOUN
dti-1332	756	3	of	of	ADP
dti-1332	756	4	the	the	DET
dti-1332	756	5	structural	structural	ADJ
dti-1332	756	6	organization	organization	NOUN
dti-1332	756	7	of	of	ADP
dti-1332	756	8	polyglutamine	polyglutamine	NOUN
dti-1332	756	9	aggregates	aggregate	NOUN
dti-1332	756	10	.	.	PUNCT
dti-1332	757	1	proc	proc	PROPN
dti-1332	757	2	.	.	PUNCT
dti-1332	758	1	natl	natl	PROPN
dti-1332	758	2	.	.	PUNCT
dti-1332	759	1	acad	acad	PROPN
dti-1332	759	2	.	.	PUNCT
dti-1332	760	1	sci	sci	PROPN
dti-1332	760	2	.	.	PUNCT
dti-1332	760	3	u.s.a	u.s.a	PROPN
dti-1332	760	4	.	.	PROPN
dti-1332	760	5	,	,	PUNCT
dti-1332	760	6	99:17014–9	99:17014–9	NUM
dti-1332	760	7	.	.	PUNCT
dti-1332	761	1	ui	ui	PROPN
dti-1332	761	2	-	-	PUNCT
dti-1332	761	3	tei	tei	NOUN
dti-1332	761	4	,	,	PUNCT
dti-1332	761	5	k.	k.	PROPN
dti-1332	761	6	,	,	PUNCT
dti-1332	761	7	naito	naito	PROPN
dti-1332	761	8	,	,	PUNCT
dti-1332	761	9	y.	y.	PROPN
dti-1332	761	10	,	,	PUNCT
dti-1332	761	11	takahashi	takahashi	PROPN
dti-1332	761	12	,	,	PUNCT
dti-1332	761	13	f.	f.	PROPN
dti-1332	761	14	et	et	PROPN
dti-1332	761	15	al	al	PROPN
dti-1332	761	16	.	.	PROPN
dti-1332	761	17	2004	2004	NUM
dti-1332	761	18	.	.	PUNCT
dti-1332	762	1	nucleic	nucleic	ADJ
dti-1332	762	2	acid	acid	PROPN
dti-1332	762	3	research	research	NOUN
dti-1332	762	4	guidelines	guideline	NOUN
dti-1332	762	5	for	for	ADP
dti-1332	762	6	the	the	DET
dti-1332	762	7	selection	selection	NOUN
dti-1332	762	8	of	of	ADP
dti-1332	762	9	highly	highly	ADV
dti-1332	762	10	effective	effective	ADJ
dti-1332	762	11	sirna	sirna	PROPN
dti-1332	762	12	sequences	sequence	NOUN
dti-1332	762	13	for	for	ADP
dti-1332	762	14	mammalian	mammalian	NOUN
dti-1332	762	15	and	and	CCONJ
dti-1332	762	16	chick	chick	NOUN
dti-1332	762	17	rna	rna	NOUN
dti-1332	762	18	interference	interference	NOUN
dti-1332	762	19	.	.	PUNCT
dti-1332	763	1	nucleic	nucleic	ADJ
dti-1332	763	2	acids	acid	NOUN
dti-1332	763	3	research	research	NOUN
dti-1332	763	4	,	,	PUNCT
dti-1332	763	5	32:936–48	32:936–48	NUM
dti-1332	763	6	.	.	PUNCT
dti-1332	764	1	van	van	PROPN
dti-1332	764	2	de	de	PROPN
dti-1332	764	3	leemput	leemput	PROPN
dti-1332	764	4	,	,	PUNCT
dti-1332	764	5	j.	j.	PROPN
dti-1332	764	6	,	,	PUNCT
dti-1332	764	7	chandran	chandran	PROPN
dti-1332	764	8	,	,	PUNCT
dti-1332	764	9	j.	j.	PROPN
dti-1332	764	10	,	,	PUNCT
dti-1332	764	11	knight	knight	PROPN
dti-1332	764	12	,	,	PUNCT
dti-1332	764	13	m.a	m.a	PROPN
dti-1332	764	14	.	.	PROPN
dti-1332	764	15	et	et	PROPN
dti-1332	764	16	al	al	PROPN
dti-1332	764	17	.	.	PROPN
dti-1332	764	18	2007	2007	NUM
dti-1332	764	19	.	.	PUNCT
dti-1332	765	1	deletion	deletion	NOUN
dti-1332	765	2	at	at	ADP
dti-1332	765	3	itpr.1	itpr.1	PROPN
dti-1332	765	4	underlies	underlie	VERB
dti-1332	765	5	ataxia	ataxia	NOUN
dti-1332	765	6	in	in	ADP
dti-1332	765	7	mice	mouse	NOUN
dti-1332	765	8	and	and	CCONJ
dti-1332	765	9	spinocerebellar	spinocerebellar	ADJ
dti-1332	765	10	ataxia	ataxia	NOUN
dti-1332	765	11	15	15	NUM
dti-1332	765	12	in	in	ADP
dti-1332	765	13	humans	human	NOUN
dti-1332	765	14	.	.	PUNCT
dti-1332	766	1	plos	plos	PROPN
dti-1332	766	2	genet	genet	PROPN
dti-1332	766	3	.	.	PUNCT
dti-1332	766	4	,	,	PUNCT
dti-1332	766	5	3	3	NUM
dti-1332	766	6	:	:	PUNCT
dti-1332	766	7	e108	e108	PROPN
dti-1332	766	8	.	.	PUNCT
dti-1332	767	1	van	van	PROPN
dti-1332	767	2	swieten	swieten	PROPN
dti-1332	767	3	,	,	PUNCT
dti-1332	767	4	j.c	j.c	PROPN
dti-1332	767	5	.	.	PROPN
dti-1332	767	6	,	,	PUNCT
dti-1332	767	7	brusse	brusse	PROPN
dti-1332	767	8	,	,	PUNCT
dti-1332	767	9	e.	e.	PROPN
dti-1332	767	10	and	and	CCONJ
dti-1332	767	11	de	de	PROPN
dti-1332	767	12	graaf	graaf	PROPN
dti-1332	767	13	,	,	PUNCT
dti-1332	767	14	b.m	b.m	PROPN
dti-1332	767	15	.	.	PROPN
dti-1332	767	16	2003	2003	NUM
dti-1332	767	17	.	.	PUNCT
dti-1332	768	1	a	a	DET
dti-1332	768	2	mutation	mutation	NOUN
dti-1332	768	3	in	in	ADP
dti-1332	768	4	the	the	DET
dti-1332	768	5	fi	fi	NOUN
dti-1332	768	6	broblast	broblast	ADJ
dti-1332	768	7	growth	growth	NOUN
dti-1332	768	8	factor	factor	NOUN
dti-1332	768	9	14	14	NUM
dti-1332	768	10	gene	gene	NOUN
dti-1332	768	11	is	be	AUX
dti-1332	768	12	associated	associate	VERB
dti-1332	768	13	with	with	ADP
dti-1332	768	14	autosomal	autosomal	ADJ
dti-1332	768	15	dominant	dominant	ADJ
dti-1332	768	16	cerebral	cerebral	ADJ
dti-1332	768	17	ataxia	ataxia	NOUN
dti-1332	768	18	.	.	PUNCT
dti-1332	769	1	am	be	AUX
dti-1332	769	2	.	.	PUNCT
dti-1332	770	1	j.	j.	PROPN
dti-1332	770	2	hum	hum	PROPN
dti-1332	770	3	.	.	PUNCT
dti-1332	771	1	genet	genet	PROPN
dti-1332	771	2	.	.	PUNCT
dti-1332	771	3	,	,	PUNCT
dti-1332	771	4	72:191–9	72:191–9	NUM
dti-1332	771	5	.	.	PUNCT
dti-1332	771	6	verbeek	verbeek	PROPN
dti-1332	771	7	,	,	PUNCT
dti-1332	771	8	d.s	d.s	PROPN
dti-1332	771	9	.	.	PROPN
dti-1332	771	10	,	,	PUNCT
dti-1332	771	11	schelhaas	schelhaas	NOUN
dti-1332	771	12	,	,	PUNCT
dti-1332	771	13	j.h	j.h	PROPN
dti-1332	771	14	.	.	PROPN
dti-1332	771	15	,	,	PUNCT
dti-1332	771	16	ippel	ippel	PROPN
dti-1332	771	17	,	,	PUNCT
dti-1332	771	18	e.f	e.f	PROPN
dti-1332	771	19	.	.	PROPN
dti-1332	771	20	et	et	PROPN
dti-1332	771	21	al	al	PROPN
dti-1332	771	22	.	.	PROPN
dti-1332	771	23	2002	2002	NUM
dti-1332	771	24	.	.	PUNCT
dti-1332	772	1	identifi	identifi	PROPN
dti-1332	772	2	cation	cation	NOUN
dti-1332	772	3	of	of	ADP
dti-1332	772	4	a	a	DET
dti-1332	772	5	novel	novel	ADJ
dti-1332	772	6	sca	sca	NOUN
dti-1332	772	7	locus	locus	NOUN
dti-1332	772	8	(	(	PUNCT
dti-1332	772	9	sca19	sca19	ADJ
dti-1332	772	10	)	)	PUNCT
dti-1332	772	11	in	in	ADP
dti-1332	772	12	a	a	DET
dti-1332	772	13	dutch	dutch	ADJ
dti-1332	772	14	autosomal	autosomal	ADJ
dti-1332	772	15	dominant	dominant	ADJ
dti-1332	772	16	cerebellar	cerebellar	ADJ
dti-1332	772	17	ataxia	ataxia	NOUN
dti-1332	772	18	family	family	NOUN
dti-1332	772	19	on	on	ADP
dti-1332	772	20	chromosome	chromosome	NOUN
dti-1332	772	21	region	region	NOUN
dti-1332	772	22	1p21	1p21	NUM
dti-1332	772	23	-	-	PUNCT
dti-1332	772	24	q21	q21	NOUN
dti-1332	772	25	.	.	PUNCT
dti-1332	773	1	hum	hum	PROPN
dti-1332	773	2	.	.	PUNCT
dti-1332	774	1	genet	genet	NOUN
dti-1332	774	2	.	.	PUNCT
dti-1332	774	3	,	,	PUNCT
dti-1332	774	4	111:388–93	111:388–93	NUM
dti-1332	774	5	.	.	PUNCT
dti-1332	775	1	verbeek	verbeek	PROPN
dti-1332	775	2	,	,	PUNCT
dti-1332	775	3	d.s	d.s	PROPN
dti-1332	775	4	.	.	PROPN
dti-1332	775	5	,	,	PUNCT
dti-1332	775	6	van	van	PROPN
dti-1332	775	7	de	de	PROPN
dti-1332	775	8	warrenburg	warrenburg	PROPN
dti-1332	775	9	,	,	PUNCT
dti-1332	775	10	b.p	b.p	PROPN
dti-1332	775	11	.	.	PROPN
dti-1332	775	12	,	,	PUNCT
dti-1332	775	13	wesseling	wesseling	NOUN
dti-1332	775	14	,	,	PUNCT
dti-1332	775	15	p.	p.	NOUN
dti-1332	775	16	et	et	NOUN
dti-1332	776	1	al	al	PROPN
dti-1332	776	2	.	.	PROPN
dti-1332	776	3	2004	2004	NUM
dti-1332	776	4	.	.	PUNCT
dti-1332	777	1	mapping	mapping	NOUN
dti-1332	777	2	of	of	ADP
dti-1332	777	3	the	the	DET
dti-1332	777	4	sca23	sca23	NOUN
dti-1332	777	5	locus	locus	NOUN
dti-1332	777	6	involved	involve	VERB
dti-1332	777	7	in	in	ADP
dti-1332	777	8	autosomal	autosomal	ADJ
dti-1332	777	9	dominant	dominant	ADJ
dti-1332	777	10	cerebellar	cerebellar	ADJ
dti-1332	777	11	ataxia	ataxia	NOUN
dti-1332	777	12	to	to	PART
dti-1332	777	13	chromosome	chromosome	VERB
dti-1332	777	14	region	region	NOUN
dti-1332	777	15	20p13	20p13	NUM
dti-1332	777	16	-	-	SYM
dti-1332	777	17	12.3	12.3	NUM
dti-1332	777	18	.	.	PUNCT
dti-1332	778	1	brain	brain	NOUN
dti-1332	778	2	,	,	PUNCT
dti-1332	778	3	127:2551–7	127:2551–7	NUM
dti-1332	778	4	.	.	PUNCT
dti-1332	778	5	voinnet	voinnet	NOUN
dti-1332	778	6	,	,	PUNCT
dti-1332	778	7	o.	o.	NOUN
dti-1332	778	8	2002	2002	NUM
dti-1332	778	9	.	.	PUNCT
dti-1332	779	1	rna	rna	NOUN
dti-1332	779	2	silencing	silencing	NOUN
dti-1332	779	3	:	:	PUNCT
dti-1332	779	4	small	small	ADJ
dti-1332	779	5	rnas	rna	NOUN
dti-1332	779	6	as	as	ADP
dti-1332	779	7	ubiquitous	ubiquitous	ADJ
dti-1332	779	8	regulators	regulator	NOUN
dti-1332	779	9	of	of	ADP
dti-1332	779	10	gene	gene	NOUN
dti-1332	779	11	expression	expression	NOUN
dti-1332	779	12	.	.	PUNCT
dti-1332	780	1	curr	curr	PROPN
dti-1332	780	2	.	.	PUNCT
dti-1332	781	1	opin	opin	NOUN
dti-1332	781	2	.	.	PUNCT
dti-1332	782	1	plant	plant	NOUN
dti-1332	782	2	biol	biol	PROPN
dti-1332	782	3	.	.	PUNCT
dti-1332	782	4	,	,	PUNCT
dti-1332	782	5	5:444–51	5:444–51	PROPN
dti-1332	782	6	.	.	NOUN
dti-1332	782	7	117	117	NUM
dti-1332	782	8	recent	recent	ADJ
dti-1332	782	9	advancements	advancement	NOUN
dti-1332	782	10	in	in	ADP
dti-1332	782	11	targeted	target	VERB
dti-1332	782	12	delivery	delivery	NOUN
dti-1332	782	13	of	of	ADP
dti-1332	782	14	therapeutic	therapeutic	ADJ
dti-1332	782	15	molecules	molecule	NOUN
dti-1332	782	16	drug	drug	NOUN
dti-1332	782	17	target	target	NOUN
dti-1332	782	18	insights	insight	NOUN
dti-1332	782	19	2008:3	2008:3	NUM
dti-1332	782	20	vuillaume	vuillaume	NOUN
dti-1332	782	21	,	,	PUNCT
dti-1332	782	22	i.	i.	PROPN
dti-1332	782	23	,	,	PUNCT
dti-1332	782	24	devos	devos	PROPN
dti-1332	782	25	,	,	PUNCT
dti-1332	782	26	d.	d.	PROPN
dti-1332	782	27	,	,	PUNCT
dti-1332	782	28	schraen	schraen	NOUN
dti-1332	782	29	-	-	PUNCT
dti-1332	782	30	maschke	maschke	PROPN
dti-1332	782	31	,	,	PUNCT
dti-1332	782	32	s.	s.	PROPN
dti-1332	782	33	et	et	PROPN
dti-1332	782	34	al	al	PROPN
dti-1332	782	35	.	.	PROPN
dti-1332	782	36	2002	2002	NUM
dti-1332	782	37	.	.	PUNCT
dti-1332	783	1	a	a	DET
dti-1332	783	2	new	new	ADJ
dti-1332	783	3	locus	locus	NOUN
dti-1332	783	4	for	for	ADP
dti-1332	783	5	spinocerebellar	spinocerebellar	ADJ
dti-1332	783	6	ataxia	ataxia	NOUN
dti-1332	783	7	(	(	PUNCT
dti-1332	783	8	sca21	sca21	ADJ
dti-1332	783	9	)	)	PUNCT
dti-1332	783	10	maps	map	NOUN
dti-1332	783	11	to	to	PART
dti-1332	783	12	chromosome	chromosome	VERB
dti-1332	783	13	7p21.3	7p21.3	NUM
dti-1332	783	14	-	-	PUNCT
dti-1332	783	15	p15.1	p15.1	PROPN
dti-1332	783	16	.	.	PUNCT
dti-1332	783	17	ann	ann	PROPN
dti-1332	783	18	.	.	PUNCT
dti-1332	784	1	neurol	neurol	PROPN
dti-1332	784	2	.	.	PUNCT
dti-1332	784	3	,	,	PUNCT
dti-1332	784	4	52:666–70	52:666–70	PROPN
dti-1332	784	5	.	.	PUNCT
dti-1332	785	1	warrenburg	warrenburg	NOUN
dti-1332	785	2	,	,	PUNCT
dti-1332	785	3	b.p.c	b.p.c	ADJ
dti-1332	785	4	.	.	PROPN
dti-1332	785	5	,	,	PUNCT
dti-1332	785	6	verbeek	verbeek	PROPN
dti-1332	785	7	,	,	PUNCT
dti-1332	785	8	d.s	d.s	PROPN
dti-1332	785	9	.	.	PROPN
dti-1332	785	10	,	,	PUNCT
dti-1332	785	11	piersma	piersma	PROPN
dti-1332	785	12	,	,	PUNCT
dti-1332	785	13	s.j	s.j	PROPN
dti-1332	785	14	.	.	PROPN
dti-1332	785	15	et	et	PROPN
dti-1332	785	16	al	al	PROPN
dti-1332	785	17	.	.	PROPN
dti-1332	785	18	2003	2003	NUM
dti-1332	785	19	.	.	PUNCT
dti-1332	786	1	identifi	identifi	PROPN
dti-1332	786	2	cation	cation	NOUN
dti-1332	786	3	of	of	ADP
dti-1332	786	4	a	a	DET
dti-1332	786	5	novel	novel	ADJ
dti-1332	786	6	sca14	sca14	NOUN
dti-1332	786	7	mutation	mutation	NOUN
dti-1332	786	8	in	in	ADP
dti-1332	786	9	a	a	DET
dti-1332	786	10	dutch	dutch	ADJ
dti-1332	786	11	autosomal	autosomal	ADJ
dti-1332	786	12	dominant	dominant	ADJ
dti-1332	786	13	cerebellar	cerebellar	PROPN
dti-1332	786	14	ataxia	ataxia	NOUN
dti-1332	786	15	family	family	NOUN
dti-1332	786	16	.	.	PUNCT
dti-1332	787	1	neurology	neurology	NOUN
dti-1332	787	2	,	,	PUNCT
dti-1332	787	3	61:1760–5	61:1760–5	NUM
dti-1332	787	4	.	.	PUNCT
dti-1332	788	1	waters	water	NOUN
dti-1332	788	2	,	,	PUNCT
dti-1332	788	3	m.f	m.f	PROPN
dti-1332	788	4	.	.	PROPN
dti-1332	788	5	,	,	PUNCT
dti-1332	788	6	minassian	minassian	PROPN
dti-1332	788	7	,	,	PUNCT
dti-1332	788	8	n.a	n.a	PROPN
dti-1332	788	9	.	.	PROPN
dti-1332	788	10	,	,	PUNCT
dti-1332	788	11	stevanin	stevanin	PROPN
dti-1332	788	12	,	,	PUNCT
dti-1332	788	13	g.	g.	PROPN
dti-1332	788	14	et	et	PROPN
dti-1332	788	15	al	al	PROPN
dti-1332	788	16	.	.	PROPN
dti-1332	788	17	2006	2006	NUM
dti-1332	788	18	.	.	PUNCT
dti-1332	789	1	mutations	mutation	NOUN
dti-1332	789	2	in	in	ADP
dti-1332	789	3	voltage	voltage	NOUN
dti-1332	789	4	-	-	PUNCT
dti-1332	789	5	gated	gate	VERB
dti-1332	789	6	potassium	potassium	NOUN
dti-1332	789	7	channel	channel	NOUN
dti-1332	789	8	kcnc3	kcnc3	NOUN
dti-1332	789	9	cause	cause	VERB
dti-1332	789	10	degenerative	degenerative	ADJ
dti-1332	789	11	and	and	CCONJ
dti-1332	789	12	developmental	developmental	ADJ
dti-1332	789	13	central	central	ADJ
dti-1332	789	14	nervous	nervous	ADJ
dti-1332	789	15	system	system	NOUN
dti-1332	789	16	phenotypes	phenotype	NOUN
dti-1332	789	17	.	.	PUNCT
dti-1332	790	1	nat	nat	NOUN
dti-1332	790	2	.	.	PUNCT
dti-1332	791	1	genet	genet	PROPN
dti-1332	791	2	.	.	PUNCT
dti-1332	791	3	,	,	PUNCT
dti-1332	791	4	38:447–51	38:447–51	NUM
dti-1332	791	5	.	.	PUNCT
dti-1332	792	1	wood	wood	NOUN
dti-1332	792	2	,	,	PUNCT
dti-1332	792	3	m.j.a	m.j.a	NOUN
dti-1332	792	4	.	.	PUNCT
dti-1332	792	5	,	,	PUNCT
dti-1332	792	6	trulzsch	trulzsch	PROPN
dti-1332	792	7	,	,	PUNCT
dti-1332	792	8	b.	b.	PROPN
dti-1332	792	9	,	,	PUNCT
dti-1332	792	10	abdelgany	abdelgany	NOUN
dti-1332	792	11	,	,	PUNCT
dti-1332	792	12	a.	a.	PROPN
dti-1332	792	13	et	et	PROPN
dti-1332	792	14	al	al	PROPN
dti-1332	792	15	.	.	PROPN
dti-1332	792	16	2003	2003	NUM
dti-1332	792	17	.	.	PUNCT
dti-1332	793	1	therapeutic	therapeutic	ADJ
dti-1332	793	2	gene	gene	NOUN
dti-1332	793	3	silencing	silence	VERB
dti-1332	793	4	in	in	ADP
dti-1332	793	5	nervous	nervous	ADJ
dti-1332	793	6	system	system	NOUN
dti-1332	793	7	.	.	PUNCT
dti-1332	794	1	human	human	ADJ
dti-1332	794	2	molecular	molecular	ADJ
dti-1332	794	3	genetics	genetic	NOUN
dti-1332	794	4	,	,	PUNCT
dti-1332	794	5	12:279–84	12:279–84	NOUN
dti-1332	794	6	.	.	PUNCT
dti-1332	795	1	j.a	j.a	PROPN
dti-1332	795	2	.	.	PROPN
dti-1332	795	3	,	,	PUNCT
dti-1332	795	4	trulzsch	trulzsch	PROPN
dti-1332	795	5	,	,	PUNCT
dti-1332	795	6	b.	b.	PROPN
dti-1332	795	7	,	,	PUNCT
dti-1332	795	8	abdelgany	abdelgany	NOUN
dti-1332	795	9	,	,	PUNCT
dti-1332	795	10	a.	a.	PROPN
dti-1332	795	11	et	et	PROPN
dti-1332	795	12	al	al	PROPN
dti-1332	795	13	.	.	PROPN
dti-1332	795	14	2003	2003	NUM
dti-1332	795	15	.	.	PUNCT
dti-1332	796	1	therapeutic	therapeutic	ADJ
dti-1332	796	2	gene	gene	NOUN
dti-1332	796	3	silencing	silence	VERB
dti-1332	796	4	in	in	ADP
dti-1332	796	5	nervous	nervous	ADJ
dti-1332	796	6	system	system	NOUN
dti-1332	796	7	.	.	PUNCT
dti-1332	797	1	human	human	ADJ
dti-1332	797	2	molecular	molecular	ADJ
dti-1332	797	3	genetics	genetic	NOUN
dti-1332	797	4	,	,	PUNCT
dti-1332	797	5	12:279–84	12:279–84	NOUN
dti-1332	797	6	.	.	PUNCT
dti-1332	798	1	worth	worth	ADJ
dti-1332	798	2	,	,	PUNCT
dti-1332	798	3	p.f	p.f	PROPN
dti-1332	798	4	.	.	PROPN
dti-1332	798	5	,	,	PUNCT
dti-1332	798	6	giunti	giunti	NOUN
dti-1332	798	7	,	,	PUNCT
dti-1332	798	8	p.	p.	NOUN
dti-1332	798	9	,	,	PUNCT
dti-1332	798	10	gardner	gardner	PROPN
dti-1332	798	11	-	-	PUNCT
dti-1332	798	12	thorpe	thorpe	PROPN
dti-1332	798	13	,	,	PUNCT
dti-1332	798	14	c.	c.	PROPN
dti-1332	798	15	et	et	PROPN
dti-1332	798	16	al	al	PROPN
dti-1332	798	17	.	.	PROPN
dti-1332	798	18	1999	1999	NUM
dti-1332	798	19	.	.	PUNCT
dti-1332	799	1	autosomal	autosomal	ADJ
dti-1332	799	2	dominant	dominant	ADJ
dti-1332	799	3	cerebellar	cerebellar	PROPN
dti-1332	799	4	ataxia	ataxia	NOUN
dti-1332	799	5	type	type	NOUN
dti-1332	799	6	iii	iii	NOUN
dti-1332	799	7	:	:	PUNCT
dti-1332	799	8	linkage	linkage	NOUN
dti-1332	799	9	in	in	ADP
dti-1332	799	10	a	a	DET
dti-1332	799	11	large	large	ADJ
dti-1332	799	12	british	british	ADJ
dti-1332	799	13	family	family	NOUN
dti-1332	799	14	to	to	ADP
dti-1332	799	15	a	a	DET
dti-1332	799	16	7.6	7.6	NUM
dti-1332	799	17	-	-	PUNCT
dti-1332	799	18	cm	cm	NOUN
dti-1332	799	19	region	region	NOUN
dti-1332	799	20	on	on	ADP
dti-1332	799	21	chromosome	chromosome	NOUN
dti-1332	799	22	15q14	15q14	NUM
dti-1332	799	23	-	-	SYM
dti-1332	799	24	21.3	21.3	NUM
dti-1332	799	25	.	.	PUNCT
dti-1332	799	26	am	be	AUX
dti-1332	799	27	.	.	PUNCT
dti-1332	800	1	j.	j.	PROPN
dti-1332	800	2	hum	hum	PROPN
dti-1332	800	3	.	.	PUNCT
dti-1332	801	1	genet	genet	PROPN
dti-1332	801	2	.	.	PUNCT
dti-1332	801	3	,	,	PUNCT
dti-1332	801	4	65:420–6	65:420–6	NUM
dti-1332	801	5	.	.	PUNCT
dti-1332	801	6	worth	worth	ADJ
dti-1332	801	7	,	,	PUNCT
dti-1332	801	8	p.f	p.f	PROPN
dti-1332	801	9	.	.	PROPN
dti-1332	801	10	2004	2004	NUM
dti-1332	801	11	.	.	PUNCT
dti-1332	802	1	sorting	sort	VERB
dti-1332	802	2	out	out	ADP
dti-1332	802	3	ataxia	ataxia	NOUN
dti-1332	802	4	in	in	ADP
dti-1332	802	5	adults	adult	NOUN
dti-1332	802	6	.	.	PUNCT
dti-1332	803	1	practical	practical	ADJ
dti-1332	803	2	neurology	neurology	NOUN
dti-1332	803	3	,	,	PUNCT
dti-1332	803	4	4:130–51	4:130–51	PROPN
dti-1332	803	5	.	.	PUNCT
dti-1332	804	1	xia	xia	PROPN
dti-1332	804	2	,	,	PUNCT
dti-1332	804	3	h.	h.	PROPN
dti-1332	804	4	,	,	PUNCT
dti-1332	804	5	mao	mao	PROPN
dti-1332	804	6	,	,	PUNCT
dti-1332	804	7	q.	q.	PROPN
dti-1332	804	8	,	,	PUNCT
dti-1332	804	9	eliason	eliason	PROPN
dti-1332	804	10	,	,	PUNCT
dti-1332	804	11	s.l	s.l	PROPN
dti-1332	804	12	.	.	PROPN
dti-1332	804	13	et	et	PROPN
dti-1332	804	14	al	al	PROPN
dti-1332	804	15	.	.	PROPN
dti-1332	804	16	2004	2004	NUM
dti-1332	804	17	.	.	PUNCT
dti-1332	805	1	rnai	rnai	PROPN
dti-1332	805	2	suppresses	suppress	VERB
dti-1332	805	3	polyglutamineinduced	polyglutamineinduce	VERB
dti-1332	805	4	neurodegeneration	neurodegeneration	NOUN
dti-1332	805	5	in	in	ADP
dti-1332	805	6	a	a	DET
dti-1332	805	7	model	model	NOUN
dti-1332	805	8	of	of	ADP
dti-1332	805	9	spinocerebellar	spinocerebellar	ADJ
dti-1332	805	10	ataxia	ataxia	NOUN
dti-1332	805	11	.	.	PUNCT
dti-1332	806	1	nat	nat	PROPN
dti-1332	806	2	.	.	PUNCT
dti-1332	807	1	med	med	PROPN
dti-1332	807	2	.	.	PROPN
dti-1332	807	3	,	,	PUNCT
dti-1332	807	4	10:816–20	10:816–20	PROPN
dti-1332	807	5	.	.	PUNCT
dti-1332	808	1	yabe	yabe	PROPN
dti-1332	808	2	,	,	PUNCT
dti-1332	808	3	i.	i.	PROPN
dti-1332	808	4	,	,	PUNCT
dti-1332	808	5	sasaki	sasaki	PROPN
dti-1332	808	6	,	,	PUNCT
dti-1332	808	7	h.	h.	PROPN
dti-1332	808	8	,	,	PUNCT
dti-1332	808	9	yamashita	yamashita	PROPN
dti-1332	808	10	,	,	PUNCT
dti-1332	808	11	i.	i.	PROPN
dti-1332	808	12	et	et	PROPN
dti-1332	808	13	al	al	PROPN
dti-1332	808	14	.	.	PROPN
dti-1332	808	15	2001	2001	NUM
dti-1332	808	16	.	.	PUNCT
dti-1332	809	1	clinical	clinical	ADJ
dti-1332	809	2	trial	trial	NOUN
dti-1332	809	3	of	of	ADP
dti-1332	809	4	acetazolamide	acetazolamide	NOUN
dti-1332	809	5	in	in	ADP
dti-1332	809	6	sca6	sca6	PROPN
dti-1332	809	7	,	,	PUNCT
dti-1332	809	8	with	with	ADP
dti-1332	809	9	assessment	assessment	NOUN
dti-1332	809	10	using	use	VERB
dti-1332	809	11	the	the	DET
dti-1332	809	12	ataxia	ataxia	NOUN
dti-1332	809	13	rating	rating	NOUN
dti-1332	809	14	scale	scale	NOUN
dti-1332	809	15	and	and	CCONJ
dti-1332	809	16	body	body	NOUN
dti-1332	809	17	stabilometry	stabilometry	NOUN
dti-1332	809	18	.	.	PUNCT
dti-1332	810	1	acta	acta	PROPN
dti-1332	810	2	.	.	PUNCT
dti-1332	811	1	neurol	neurol	PROPN
dti-1332	811	2	.	.	PUNCT
dti-1332	812	1	scand	scand	PROPN
dti-1332	812	2	,	,	PUNCT
dti-1332	812	3	104:44–7	104:44–7	NUM
dti-1332	812	4	.	.	PUNCT
dti-1332	813	1	yabe	yabe	PROPN
dti-1332	813	2	,	,	PUNCT
dti-1332	813	3	i.	i.	PROPN
dti-1332	813	4	,	,	PUNCT
dti-1332	813	5	sasaki	sasaki	PROPN
dti-1332	813	6	,	,	PUNCT
dti-1332	813	7	h.	h.	PROPN
dti-1332	813	8	,	,	PUNCT
dti-1332	813	9	chen	chen	PROPN
dti-1332	813	10	,	,	PUNCT
dti-1332	813	11	d.h	d.h	PROPN
dti-1332	813	12	.	.	PROPN
dti-1332	813	13	et	et	PROPN
dti-1332	813	14	al	al	PROPN
dti-1332	813	15	.	.	PROPN
dti-1332	813	16	2003	2003	NUM
dti-1332	813	17	.	.	PUNCT
dti-1332	814	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	814	2	ataxia	ataxia	NOUN
dti-1332	814	3	type	type	NOUN
dti-1332	814	4	14	14	NUM
dti-1332	814	5	caused	cause	VERB
dti-1332	814	6	by	by	ADP
dti-1332	814	7	a	a	DET
dti-1332	814	8	mutation	mutation	NOUN
dti-1332	814	9	in	in	ADP
dti-1332	814	10	protein	protein	NOUN
dti-1332	814	11	kinase	kinase	PROPN
dti-1332	814	12	c	c	PROPN
dti-1332	814	13	gamma	gamma	PROPN
dti-1332	814	14	.	.	PUNCT
dti-1332	814	15	arch	arch	PROPN
dti-1332	814	16	.	.	PUNCT
dti-1332	815	1	neurol	neurol	NOUN
dti-1332	815	2	.	.	PUNCT
dti-1332	815	3	,	,	PUNCT
dti-1332	815	4	60:1749–51	60:1749–51	PROPN
dti-1332	815	5	.	.	PUNCT
dti-1332	816	1	yamashita	yamashita	PROPN
dti-1332	816	2	,	,	PUNCT
dti-1332	816	3	i.	i.	PROPN
dti-1332	816	4	,	,	PUNCT
dti-1332	816	5	sasaki	sasaki	PROPN
dti-1332	816	6	,	,	PUNCT
dti-1332	816	7	h.	h.	PROPN
dti-1332	816	8	,	,	PUNCT
dti-1332	816	9	yabe	yabe	PROPN
dti-1332	816	10	,	,	PUNCT
dti-1332	816	11	i.	i.	PROPN
dti-1332	816	12	et	et	PROPN
dti-1332	816	13	al	al	PROPN
dti-1332	816	14	.	.	PROPN
dti-1332	816	15	2000	2000	NUM
dti-1332	816	16	.	.	PUNCT
dti-1332	817	1	a	a	DET
dti-1332	817	2	novel	novel	ADJ
dti-1332	817	3	locus	locus	NOUN
dti-1332	817	4	for	for	ADP
dti-1332	817	5	dominant	dominant	ADJ
dti-1332	817	6	cerebellar	cerebellar	ADJ
dti-1332	817	7	ataxia	ataxia	NOUN
dti-1332	817	8	(	(	PUNCT
dti-1332	817	9	sca14	sca14	NOUN
dti-1332	817	10	)	)	PUNCT
dti-1332	817	11	maps	map	NOUN
dti-1332	817	12	to	to	ADP
dti-1332	817	13	a	a	DET
dti-1332	817	14	10.2	10.2	NUM
dti-1332	817	15	-	-	PUNCT
dti-1332	817	16	cm	cm	NOUN
dti-1332	817	17	interval	interval	NOUN
dti-1332	817	18	fl	fl	PROPN
dti-1332	817	19	anked	anke	VERB
dti-1332	817	20	by	by	ADP
dti-1332	817	21	d19s206	d19s206	PROPN
dti-1332	817	22	and	and	CCONJ
dti-1332	817	23	d19s605	d19s605	VERB
dti-1332	817	24	on	on	ADP
dti-1332	817	25	chromosome	chromosome	NOUN
dti-1332	817	26	19q13.4	19q13.4	NUM
dti-1332	817	27	-	-	PUNCT
dti-1332	817	28	qter	qter	NOUN
dti-1332	817	29	.	.	PUNCT
dti-1332	818	1	annals	annal	NOUN
dti-1332	818	2	of	of	ADP
dti-1332	818	3	neurology	neurology	NOUN
dti-1332	818	4	,	,	PUNCT
dti-1332	818	5	48:156–63	48:156–63	NOUN
dti-1332	818	6	.	.	PUNCT
dti-1332	819	1	yu	yu	PROPN
dti-1332	819	2	,	,	PUNCT
dti-1332	819	3	g.y	g.y	PROPN
dti-1332	819	4	.	.	PROPN
dti-1332	819	5	,	,	PUNCT
dti-1332	819	6	howell	howell	PROPN
dti-1332	819	7	,	,	PUNCT
dti-1332	819	8	m.j	m.j	PROPN
dti-1332	819	9	.	.	PROPN
dti-1332	819	10	,	,	PUNCT
dti-1332	819	11	roller	roller	NOUN
dti-1332	819	12	,	,	PUNCT
dti-1332	819	13	m.j	m.j	PROPN
dti-1332	819	14	.	.	PROPN
dti-1332	819	15	et	et	PROPN
dti-1332	819	16	al	al	PROPN
dti-1332	819	17	.	.	PROPN
dti-1332	819	18	2005	2005	NUM
dti-1332	819	19	.	.	PUNCT
dti-1332	820	1	spinocerebellar	spinocerebellar	ADJ
dti-1332	820	2	ataxia	ataxia	NOUN
dti-1332	820	3	type	type	NOUN
dti-1332	820	4	26	26	NUM
dti-1332	820	5	maps	map	NOUN
dti-1332	820	6	to	to	PART
dti-1332	820	7	chromosome	chromosome	VERB
dti-1332	820	8	19p13.3	19p13.3	NUM
dti-1332	820	9	adjacent	adjacent	ADJ
dti-1332	820	10	to	to	ADP
dti-1332	820	11	sca6	sca6	PROPN
dti-1332	820	12	.	.	PUNCT
dti-1332	821	1	ann	ann	PROPN
dti-1332	821	2	.	.	PUNCT
dti-1332	822	1	neurol	neurol	PROPN
dti-1332	822	2	.	.	PUNCT
dti-1332	822	3	,	,	PUNCT
dti-1332	822	4	57:349–54	57:349–54	PROPN
dti-1332	822	5	.	.	PUNCT
dti-1332	823	1	zhuchenko	zhuchenko	PROPN
dti-1332	823	2	,	,	PUNCT
dti-1332	823	3	o.	o.	PROPN
dti-1332	823	4	,	,	PUNCT
dti-1332	823	5	bailey	bailey	PROPN
dti-1332	823	6	,	,	PUNCT
dti-1332	823	7	j.	j.	PROPN
dti-1332	823	8	,	,	PUNCT
dti-1332	823	9	bonnen	bonnen	PROPN
dti-1332	823	10	,	,	PUNCT
dti-1332	823	11	p.	p.	NOUN
dti-1332	823	12	et	et	NOUN
dti-1332	824	1	al	al	PROPN
dti-1332	824	2	.	.	PROPN
dti-1332	824	3	1997	1997	NUM
dti-1332	824	4	.	.	PUNCT
dti-1332	825	1	autosomal	autosomal	ADJ
dti-1332	825	2	dominant	dominant	ADJ
dti-1332	825	3	cerebellar	cerebellar	ADJ
dti-1332	825	4	ataxia	ataxia	NOUN
dti-1332	825	5	(	(	PUNCT
dti-1332	825	6	sca6	sca6	PROPN
dti-1332	825	7	)	)	PUNCT
dti-1332	825	8	associated	associate	VERB
dti-1332	825	9	with	with	ADP
dti-1332	825	10	small	small	ADJ
dti-1332	825	11	polyglutamine	polyglutamine	NOUN
dti-1332	825	12	expansions	expansion	NOUN
dti-1332	825	13	in	in	ADP
dti-1332	825	14	the	the	DET
dti-1332	825	15	1a	1a	NUM
dti-1332	825	16	-	-	PUNCT
dti-1332	825	17	voltage	voltage	NOUN
dti-1332	825	18	-	-	PUNCT
dti-1332	825	19	dependent	dependent	ADJ
dti-1332	825	20	calcium	calcium	NOUN
dti-1332	825	21	channel	channel	NOUN
dti-1332	825	22	.	.	PUNCT
dti-1332	826	1	nat	nat	PROPN
dti-1332	826	2	.	.	PUNCT
dti-1332	827	1	genet	genet	PROPN
dti-1332	827	2	.	.	PUNCT
dti-1332	827	3	,	,	PUNCT
dti-1332	827	4	15:62–9	15:62–9	X
dti-1332	827	5	.	.	PUNCT
dti-1332	827	6	zoghbi	zoghbi	PROPN
dti-1332	827	7	,	,	PUNCT
dti-1332	827	8	h.y	h.y	PROPN
dti-1332	827	9	.	.	PROPN
dti-1332	827	10	and	and	CCONJ
dti-1332	827	11	orr	orr	PROPN
dti-1332	827	12	,	,	PUNCT
dti-1332	827	13	h.t	h.t	PROPN
dti-1332	827	14	.	.	PROPN
dti-1332	827	15	2000	2000	NUM
dti-1332	827	16	.	.	PUNCT
dti-1332	828	1	glutamine	glutamine	NOUN
dti-1332	828	2	repeats	repeat	NOUN
dti-1332	828	3	and	and	CCONJ
dti-1332	828	4	neurodegeneration	neurodegeneration	NOUN
dti-1332	828	5	.	.	PUNCT
dti-1332	829	1	annu	annu	NOUN
dti-1332	829	2	.	.	PUNCT
dti-1332	830	1	rev	rev	PROPN
dti-1332	830	2	.	.	PROPN
dti-1332	830	3	neurosci	neurosci	PROPN
dti-1332	830	4	,	,	PUNCT
dti-1332	830	5	23:217–47	23:217–47	NOUN
dti-1332	830	6	.	.	PUNCT
dti-1332	831	1	zu	zu	NUM
dti-1332	831	2	,	,	PUNCT
dti-1332	831	3	l.	l.	PROPN
dti-1332	831	4	,	,	PUNCT
dti-1332	831	5	figueroa	figueroa	PROPN
dti-1332	831	6	,	,	PUNCT
dti-1332	831	7	k.p	k.p	PROPN
dti-1332	831	8	.	.	PROPN
dti-1332	831	9	,	,	PUNCT
dti-1332	831	10	grewal	grewal	PROPN
dti-1332	831	11	,	,	PUNCT
dti-1332	831	12	r.	r.	PROPN
dti-1332	831	13	et	et	PROPN
dti-1332	831	14	al	al	PROPN
dti-1332	831	15	.	.	PROPN
dti-1332	831	16	1999	1999	NUM
dti-1332	831	17	.	.	PUNCT
dti-1332	832	1	mapping	mapping	NOUN
dti-1332	832	2	of	of	ADP
dti-1332	832	3	a	a	DET
dti-1332	832	4	new	new	ADJ
dti-1332	832	5	autosomal	autosomal	ADJ
dti-1332	832	6	dominant	dominant	ADJ
dti-1332	832	7	spinocerebellar	spinocerebellar	NOUN
dti-1332	832	8	ataxia	ataxia	NOUN
dti-1332	832	9	to	to	PART
dti-1332	832	10	chromosome	chromosome	VERB
dti-1332	832	11	22	22	NUM
dti-1332	832	12	.	.	PUNCT
dti-1332	833	1	am	be	AUX
dti-1332	833	2	.	.	PUNCT
dti-1332	834	1	j.	j.	PROPN
dti-1332	834	2	hum	hum	PROPN
dti-1332	834	3	.	.	PUNCT
dti-1332	835	1	genet	genet	PROPN
dti-1332	835	2	.	.	PUNCT
dti-1332	835	3	,	,	PUNCT
dti-1332	835	4	64:594–9	64:594–9	NUM
dti-1332	835	5	.	.	PUNCT
dti-1332	836	1	<	<	X
dti-1332	836	2	<	<	X
dti-1332	836	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1332	836	4	false	false	ADJ
dti-1332	836	5	/allowtransparency	/allowtransparency	NOUN
dti-1332	836	6	false	false	ADJ
dti-1332	836	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1332	836	8	true	true	ADJ
dti-1332	836	9	/autorotatepages	/autorotatepage	NOUN
dti-1332	836	10	/none	/none	PUNCT
dti-1332	836	11	/binding	/binding	PUNCT
dti-1332	836	12	/left	/left	ADJ
dti-1332	837	1	/calgrayprofile	/calgrayprofile	VERB
dti-1332	837	2	(	(	PUNCT
dti-1332	837	3	dot	dot	NOUN
dti-1332	837	4	gain	gain	NOUN
dti-1332	837	5	20	20	NUM
dti-1332	837	6	%	%	NOUN
dti-1332	837	7	)	)	PUNCT
dti-1332	837	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1332	838	1	(	(	PUNCT
dti-1332	838	2	srgb	srgb	PROPN
dti-1332	838	3	iec61966	iec61966	NOUN
dti-1332	838	4	-	-	PUNCT
dti-1332	838	5	2.1	2.1	NUM
dti-1332	838	6	)	)	PUNCT
dti-1332	838	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1332	839	1	(	(	PUNCT
dti-1332	839	2	u.s	u.s	PROPN
dti-1332	839	3	.	.	PROPN
dti-1332	839	4	web	web	NOUN
dti-1332	839	5	coated	coat	VERB
dti-1332	839	6	\050swop\051	\050swop\051	ADJ
dti-1332	839	7	v2	v2	NOUN
dti-1332	839	8	)	)	PUNCT
dti-1332	839	9	/srgbprofile	/srgbprofile	PUNCT
dti-1332	839	10	(	(	PUNCT
dti-1332	839	11	srgb	srgb	PROPN
dti-1332	839	12	iec61966	iec61966	NOUN
dti-1332	839	13	-	-	PUNCT
dti-1332	839	14	2.1	2.1	NUM
dti-1332	839	15	)	)	PUNCT
dti-1332	839	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1332	840	1	/error	/error	INTJ
dti-1332	840	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1332	841	1	1.4	1.4	NUM
dti-1332	841	2	/compressobjects	/compressobject	NOUN
dti-1332	841	3	/tags	/tag	VERB
dti-1332	841	4	/compresspages	/compresspage	NOUN
dti-1332	841	5	true	true	ADJ
dti-1332	841	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1332	841	7	true	true	ADJ
dti-1332	841	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1332	841	9	true	true	ADJ
dti-1332	841	10	/createjdffile	/createjdffile	ADJ
dti-1332	841	11	false	false	ADJ
dti-1332	841	12	/createjobticket	/createjobticket	NOUN
dti-1332	841	13	false	false	ADJ
dti-1332	841	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1332	841	15	/default	/default	PUNCT
dti-1332	841	16	/detectblends	/detectblend	NOUN
dti-1332	841	17	true	true	ADJ
dti-1332	841	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1332	841	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1332	841	20	/dothumbnails	/dothumbnail	VERB
dti-1332	841	21	false	false	ADJ
dti-1332	841	22	/embedallfonts	/embedallfont	NOUN
dti-1332	841	23	true	true	ADJ
dti-1332	841	24	/embedjoboptions	/embedjoboption	NOUN
dti-1332	841	25	true	true	ADJ
dti-1332	841	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1332	841	27	0	0	NUM
dti-1332	841	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1332	841	29	false	false	ADJ
dti-1332	841	30	/endpage	/endpage	NOUN
dti-1332	841	31	-1	-1	NOUN
dti-1332	841	32	/imagememory	/imagememory	NUM
dti-1332	842	1	1048576	1048576	NUM
dti-1332	842	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1332	842	3	false	false	ADJ
dti-1332	842	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1332	842	5	100	100	NUM
dti-1332	842	6	/optimize	/optimize	NOUN
dti-1332	842	7	true	true	ADJ
dti-1332	842	8	/opm	/opm	NOUN
dti-1332	842	9	1	1	NUM
dti-1332	842	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1332	842	11	true	true	ADJ
dti-1332	842	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1332	842	13	true	true	ADJ
dti-1332	842	14	/preservecopypage	/preservecopypage	NOUN
dti-1332	842	15	true	true	ADJ
dti-1332	842	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1332	842	17	true	true	ADJ
dti-1332	842	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1332	842	19	false	false	ADJ
dti-1332	842	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1332	842	21	false	false	ADJ
dti-1332	842	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1332	842	23	true	true	ADJ
dti-1332	842	24	/startpage	/startpage	NOUN
dti-1332	842	25	1	1	NUM
dti-1332	842	26	/subsetfonts	/subsetfont	NOUN
dti-1332	842	27	true	true	ADJ
dti-1332	842	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1332	842	29	/apply	/apply	PUNCT
dti-1332	842	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1332	843	1	/preserve	/preserve	NOUN
dti-1332	843	2	/useprologue	/useprologue	NOUN
dti-1332	843	3	false	false	ADJ
dti-1332	843	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1332	843	5	(	(	PUNCT
dti-1332	843	6	)	)	PUNCT
dti-1332	843	7	/alwaysembed	/alwaysembe	VERB
dti-1332	843	8	[	[	PUNCT
dti-1332	843	9	true	true	ADJ
dti-1332	843	10	]	]	PUNCT
dti-1332	843	11	/neverembed	/neverembed	PUNCT
dti-1332	844	1	[	[	PUNCT
dti-1332	844	2	true	true	ADJ
dti-1332	844	3	]	]	PUNCT
dti-1332	844	4	/antialiascolorimages	/antialiascolorimages	X
dti-1332	844	5	false	false	ADJ
dti-1332	844	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1332	844	7	true	true	ADJ
dti-1332	844	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1332	844	9	/bicubic	/bicubic	NOUN
dti-1332	844	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1332	844	11	300	300	NUM
dti-1332	844	12	/colorimagedepth	/colorimagedepth	PRON
dti-1332	845	1	-1	-1	INTJ
dti-1332	845	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1332	845	3	1.50000	1.50000	NUM
dti-1332	845	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1332	845	5	true	true	ADJ
dti-1332	845	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1332	845	7	/dctencode	/dctencode	PUNCT
dti-1332	845	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1332	845	9	true	true	ADJ
dti-1332	845	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1332	845	11	/jpeg	/jpeg	PUNCT
dti-1332	845	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1332	846	1	<	<	X
dti-1332	846	2	<	<	X
dti-1332	846	3	/qfactor	/qfactor	NOUN
dti-1332	846	4	0.15	0.15	NUM
dti-1332	846	5	/hsamples	/hsample	NOUN
dti-1332	847	1	[	[	X
dti-1332	847	2	1	1	NUM
dti-1332	847	3	1	1	NUM
dti-1332	847	4	1	1	NUM
dti-1332	847	5	1	1	NUM
dti-1332	847	6	]	]	PUNCT
dti-1332	847	7	/vsamples	/vsample	NOUN
dti-1332	848	1	[	[	X
dti-1332	848	2	1	1	NUM
dti-1332	848	3	1	1	NUM
dti-1332	848	4	1	1	NUM
dti-1332	848	5	1	1	NUM
dti-1332	848	6	]	]	PUNCT
dti-1332	848	7	>	>	PUNCT
dti-1332	848	8	>	>	X
dti-1332	848	9	/colorimagedict	/colorimagedict	PUNCT
dti-1332	849	1	<	<	X
dti-1332	849	2	<	<	X
dti-1332	849	3	/qfactor	/qfactor	NOUN
dti-1332	849	4	0.15	0.15	NUM
dti-1332	849	5	/hsamples	/hsample	NOUN
dti-1332	850	1	[	[	X
dti-1332	850	2	1	1	NUM
dti-1332	850	3	1	1	NUM
dti-1332	850	4	1	1	NUM
dti-1332	850	5	1	1	NUM
dti-1332	850	6	]	]	PUNCT
dti-1332	850	7	/vsamples	/vsample	NOUN
dti-1332	851	1	[	[	X
dti-1332	851	2	1	1	NUM
dti-1332	851	3	1	1	NUM
dti-1332	851	4	1	1	NUM
dti-1332	851	5	1	1	NUM
dti-1332	851	6	]	]	PUNCT
dti-1332	851	7	>	>	PUNCT
dti-1332	851	8	>	>	X
dti-1332	851	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1332	852	1	<	<	X
dti-1332	852	2	<	<	X
dti-1332	852	3	/tilewidth	/tilewidth	PUNCT
dti-1332	852	4	256	256	NUM
dti-1332	852	5	/tileheight	/tileheight	NUM
dti-1332	852	6	256	256	NUM
dti-1332	852	7	/quality	/quality	NOUN
dti-1332	852	8	30	30	NUM
dti-1332	852	9	>	>	PUNCT
dti-1332	852	10	>	>	X
dti-1332	852	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1332	852	12	<	<	X
dti-1332	852	13	<	<	X
dti-1332	852	14	/tilewidth	/tilewidth	PUNCT
dti-1332	852	15	256	256	NUM
dti-1332	852	16	/tileheight	/tileheight	NUM
dti-1332	852	17	256	256	NUM
dti-1332	852	18	/quality	/quality	NOUN
dti-1332	852	19	30	30	NUM
dti-1332	852	20	>	>	PUNCT
dti-1332	852	21	>	>	X
dti-1332	852	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1332	852	23	false	false	ADJ
dti-1332	852	24	/downsamplegrayimages	/downsamplegrayimage	NOUN
dti-1332	853	1	true	true	ADJ
dti-1332	853	2	/grayimagedownsampletype	/grayimagedownsampletype	NOUN
dti-1332	853	3	/bicubic	/bicubic	NOUN
dti-1332	853	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1332	853	5	300	300	NUM
dti-1332	853	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1332	853	7	-1	-1	PUNCT
dti-1332	853	8	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	PRON
dti-1332	854	1	1.50000	1.50000	NUM
dti-1332	854	2	/encodegrayimages	/encodegrayimage	NOUN
dti-1332	854	3	true	true	ADJ
dti-1332	854	4	/grayimagefilter	/grayimagefilter	NOUN
dti-1332	854	5	/dctencode	/dctencode	PUNCT
dti-1332	855	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1332	855	2	true	true	ADJ
dti-1332	855	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1332	855	4	/jpeg	/jpeg	PUNCT
dti-1332	855	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1332	856	1	<	<	X
dti-1332	856	2	<	<	X
dti-1332	856	3	/qfactor	/qfactor	NOUN
dti-1332	856	4	0.15	0.15	NUM
dti-1332	856	5	/hsamples	/hsample	NOUN
dti-1332	857	1	[	[	X
dti-1332	857	2	1	1	NUM
dti-1332	857	3	1	1	NUM
dti-1332	857	4	1	1	NUM
dti-1332	857	5	1	1	NUM
dti-1332	857	6	]	]	PUNCT
dti-1332	857	7	/vsamples	/vsample	NOUN
dti-1332	858	1	[	[	X
dti-1332	858	2	1	1	NUM
dti-1332	858	3	1	1	NUM
dti-1332	858	4	1	1	NUM
dti-1332	858	5	1	1	NUM
dti-1332	858	6	]	]	PUNCT
dti-1332	858	7	>	>	PUNCT
dti-1332	858	8	>	>	X
dti-1332	858	9	/grayimagedict	/grayimagedict	PUNCT
dti-1332	859	1	<	<	X
dti-1332	859	2	<	<	X
dti-1332	859	3	/qfactor	/qfactor	NOUN
dti-1332	859	4	0.15	0.15	NUM
dti-1332	859	5	/hsamples	/hsample	NOUN
dti-1332	860	1	[	[	X
dti-1332	860	2	1	1	NUM
dti-1332	860	3	1	1	NUM
dti-1332	860	4	1	1	NUM
dti-1332	860	5	1	1	NUM
dti-1332	860	6	]	]	PUNCT
dti-1332	860	7	/vsamples	/vsample	NOUN
dti-1332	861	1	[	[	X
dti-1332	861	2	1	1	NUM
dti-1332	861	3	1	1	NUM
dti-1332	861	4	1	1	NUM
dti-1332	861	5	1	1	NUM
dti-1332	861	6	]	]	PUNCT
dti-1332	861	7	>	>	X
dti-1332	861	8	>	>	X
dti-1332	861	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1332	862	1	<	<	X
dti-1332	862	2	<	<	X
dti-1332	862	3	/tilewidth	/tilewidth	PUNCT
dti-1332	862	4	256	256	NUM
dti-1332	862	5	/tileheight	/tileheight	NUM
dti-1332	862	6	256	256	NUM
dti-1332	862	7	/quality	/quality	NOUN
dti-1332	862	8	30	30	NUM
dti-1332	862	9	>	>	PUNCT
dti-1332	862	10	>	>	X
dti-1332	862	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1332	862	12	<	<	X
dti-1332	862	13	<	<	X
dti-1332	862	14	/tilewidth	/tilewidth	PUNCT
dti-1332	862	15	256	256	NUM
dti-1332	862	16	/tileheight	/tileheight	NUM
dti-1332	862	17	256	256	NUM
dti-1332	862	18	/quality	/quality	NOUN
dti-1332	862	19	30	30	NUM
dti-1332	862	20	>	>	PUNCT
dti-1332	862	21	>	>	X
dti-1332	862	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1332	862	23	false	false	ADJ
dti-1332	862	24	/downsamplemonoimages	/downsamplemonoimage	NOUN
dti-1332	862	25	true	true	ADJ
dti-1332	862	26	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1332	862	27	/bicubic	/bicubic	NOUN
dti-1332	862	28	/monoimageresolution	/monoimageresolution	NOUN
dti-1332	862	29	1200	1200	NUM
dti-1332	862	30	/monoimagedepth	/monoimagedepth	PRON
dti-1332	862	31	-1	-1	PUNCT
dti-1332	862	32	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1332	862	33	1.50000	1.50000	NUM
dti-1332	862	34	/encodemonoimages	/encodemonoimage	NOUN
dti-1332	862	35	true	true	ADJ
dti-1332	862	36	/monoimagefilter	/monoimagefilter	ADP
dti-1332	862	37	/ccittfaxencode	/ccittfaxencode	INTJ
dti-1332	862	38	/monoimagedict	/monoimagedict	PUNCT
dti-1332	863	1	<	<	X
dti-1332	863	2	<	<	X
dti-1332	863	3	/k	/k	PUNCT
dti-1332	863	4	-1	-1	INTJ
dti-1332	863	5	>	>	PUNCT
dti-1332	863	6	>	>	X
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dti-1332	876	8	/sve	/sve	NOUN
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dti-1332	877	4	/enu	/enu	PROPN
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dti-1332	877	7	>	>	X
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dti-1332	877	9	>	>	X
dti-1332	877	10	>	>	X
dti-1332	877	11	>	>	X
dti-1332	877	12	setdistillerparams	setdistillerparam	NOUN
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dti-1332	878	3	/hwresolution	/hwresolution	NOUN
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dti-1332	879	2	2400	2400	NUM
dti-1332	879	3	2400	2400	NUM
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dti-1332	879	5	/pagesize	/pagesize	X
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dti-1332	880	5	>	>	PUNCT
dti-1332	880	6	>	>	X
dti-1332	880	7	setpagedevice	setpagedevice	PROPN