id	sid	tid	token	lemma	pos
dti-1335	1	1	wilczak	wilczak	NOUN
dti-1335	1	2	et	et	PROPN
dti-1335	1	3	al.indd	al.indd	NOUN
dti-1335	1	4	drug	drug	NOUN
dti-1335	1	5	target	target	NOUN
dti-1335	1	6	insights	insight	NOUN
dti-1335	1	7	2008:3	2008:3	NUM
dti-1335	1	8	37–44	37–44	NUM
dti-1335	1	9	37	37	NUM
dti-1335	1	10	review	review	NOUN
dti-1335	1	11	correspondence	correspondence	NOUN
dti-1335	1	12	:	:	PUNCT
dti-1335	1	13	dr	dr	PROPN
dti-1335	1	14	.	.	PROPN
dti-1335	1	15	n.	n.	PROPN
dti-1335	1	16	wilczak	wilczak	PROPN
dti-1335	1	17	,	,	PUNCT
dti-1335	1	18	university	university	NOUN
dti-1335	1	19	medical	medical	ADJ
dti-1335	1	20	center	center	PROPN
dti-1335	1	21	groningen	groningen	PROPN
dti-1335	1	22	,	,	PUNCT
dti-1335	1	23	department	department	NOUN
dti-1335	1	24	neurology	neurology	NOUN
dti-1335	1	25	,	,	PUNCT
dti-1335	1	26	postbus	postbus	PROPN
dti-1335	1	27	30001	30001	NUM
dti-1335	1	28	,	,	PUNCT
dti-1335	1	29	hanzeplein	hanzeplein	NOUN
dti-1335	1	30	1	1	NUM
dti-1335	1	31	,	,	PUNCT
dti-1335	1	32	9700	9700	NUM
dti-1335	1	33	rb	rb	PROPN
dti-1335	1	34	groningen	groningen	PROPN
dti-1335	1	35	,	,	PUNCT
dti-1335	1	36	the	the	DET
dti-1335	1	37	netherlands	netherlands	PROPN
dti-1335	1	38	.	.	PUNCT
dti-1335	2	1	tel	tel	ADP
dti-1335	2	2	:	:	PUNCT
dti-1335	2	3	0031	0031	NUM
dti-1335	2	4	-	-	SYM
dti-1335	2	5	50	50	NUM
dti-1335	2	6	-	-	NUM
dti-1335	2	7	3637719	3637719	NUM
dti-1335	2	8	;	;	PUNCT
dti-1335	2	9	fax	fax	NOUN
dti-1335	2	10	:	:	PUNCT
dti-1335	2	11	0031	0031	NUM
dti-1335	2	12	-	-	SYM
dti-1335	2	13	50	50	NUM
dti-1335	2	14	-	-	PUNCT
dti-1335	2	15	3611707	3611707	NUM
dti-1335	2	16	.	.	PUNCT
dti-1335	3	1	copyright	copyright	NOUN
dti-1335	3	2	in	in	ADP
dti-1335	3	3	this	this	DET
dti-1335	3	4	article	article	NOUN
dti-1335	3	5	,	,	PUNCT
dti-1335	3	6	its	its	PRON
dti-1335	3	7	metadata	metadata	NOUN
dti-1335	3	8	,	,	PUNCT
dti-1335	3	9	and	and	CCONJ
dti-1335	3	10	any	any	DET
dti-1335	3	11	supplementary	supplementary	ADJ
dti-1335	3	12	data	datum	NOUN
dti-1335	3	13	is	be	AUX
dti-1335	3	14	held	hold	VERB
dti-1335	3	15	by	by	ADP
dti-1335	3	16	its	its	PRON
dti-1335	3	17	author	author	NOUN
dti-1335	3	18	or	or	CCONJ
dti-1335	3	19	authors	author	NOUN
dti-1335	3	20	.	.	PUNCT
dti-1335	4	1	it	it	PRON
dti-1335	4	2	is	be	AUX
dti-1335	4	3	published	publish	VERB
dti-1335	4	4	under	under	ADP
dti-1335	4	5	the	the	DET
dti-1335	4	6	creative	creative	ADJ
dti-1335	4	7	commons	common	NOUN
dti-1335	4	8	attribution	attribution	NOUN
dti-1335	4	9	by	by	ADP
dti-1335	4	10	licence	licence	NOUN
dti-1335	4	11	.	.	PUNCT
dti-1335	5	1	for	for	SCONJ
dti-1335	5	2	further	further	ADJ
dti-1335	5	3	information	information	NOUN
dti-1335	5	4	go	go	VERB
dti-1335	5	5	to	to	ADP
dti-1335	5	6	:	:	PUNCT
dti-1335	5	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	VERB
dti-1335	5	8	targeting	target	VERB
dti-1335	5	9	insulin	insulin	NOUN
dti-1335	5	10	-	-	PUNCT
dti-1335	5	11	like	like	ADJ
dti-1335	5	12	growth	growth	NOUN
dti-1335	5	13	factor-1	factor-1	NUM
dti-1335	5	14	signaling	signal	VERB
dti-1335	5	15	into	into	ADP
dti-1335	5	16	the	the	DET
dti-1335	5	17	central	central	ADJ
dti-1335	5	18	nervous	nervous	ADJ
dti-1335	5	19	system	system	NOUN
dti-1335	5	20	for	for	ADP
dti-1335	5	21	promoting	promote	VERB
dti-1335	5	22	myelin	myelin	ADJ
dti-1335	5	23	repair	repair	NOUN
dti-1335	5	24	nadine	nadine	PROPN
dti-1335	5	25	wilczak	wilczak	PROPN
dti-1335	5	26	,	,	PUNCT
dti-1335	5	27	jacques	jacques	PROPN
dti-1335	5	28	de	de	PROPN
dti-1335	5	29	keyser	keyser	PROPN
dti-1335	5	30	and	and	CCONJ
dti-1335	5	31	daniel	daniel	PROPN
dti-1335	5	32	chesik	chesik	PROPN
dti-1335	5	33	department	department	PROPN
dti-1335	5	34	of	of	ADP
dti-1335	5	35	neurology	neurology	NOUN
dti-1335	5	36	,	,	PUNCT
dti-1335	5	37	university	university	NOUN
dti-1335	5	38	medical	medical	ADJ
dti-1335	5	39	center	center	NOUN
dti-1335	5	40	groningen	groningen	PROPN
dti-1335	5	41	,	,	PUNCT
dti-1335	5	42	the	the	DET
dti-1335	5	43	netherlands	netherlands	PROPN
dti-1335	5	44	.	.	PUNCT
dti-1335	6	1	abstract	abstract	ADJ
dti-1335	6	2	:	:	PUNCT
dti-1335	6	3	multiple	multiple	ADJ
dti-1335	6	4	sclerosis	sclerosis	NOUN
dti-1335	6	5	(	(	PUNCT
dti-1335	6	6	ms	ms	NOUN
dti-1335	6	7	)	)	PUNCT
dti-1335	6	8	is	be	AUX
dti-1335	6	9	the	the	DET
dti-1335	6	10	most	most	ADV
dti-1335	6	11	common	common	ADJ
dti-1335	6	12	demyelinating	demyelinate	VERB
dti-1335	6	13	disease	disease	NOUN
dti-1335	6	14	of	of	ADP
dti-1335	6	15	the	the	DET
dti-1335	6	16	central	central	ADJ
dti-1335	6	17	nervous	nervous	ADJ
dti-1335	6	18	system	system	NOUN
dti-1335	6	19	(	(	PUNCT
dti-1335	6	20	cns	cns	NOUN
dti-1335	6	21	)	)	PUNCT
dti-1335	6	22	.	.	PUNCT
dti-1335	7	1	without	without	ADP
dti-1335	7	2	myelin	myelin	NOUN
dti-1335	7	3	,	,	PUNCT
dti-1335	7	4	nerve	nerve	NOUN
dti-1335	7	5	impulses	impulse	NOUN
dti-1335	7	6	in	in	ADP
dti-1335	7	7	the	the	DET
dti-1335	7	8	cns	cns	NOUN
dti-1335	7	9	are	be	AUX
dti-1335	7	10	slowed	slow	VERB
dti-1335	7	11	or	or	CCONJ
dti-1335	7	12	stopped	stop	VERB
dti-1335	7	13	,	,	PUNCT
dti-1335	7	14	leading	lead	VERB
dti-1335	7	15	to	to	ADP
dti-1335	7	16	a	a	DET
dti-1335	7	17	constellation	constellation	NOUN
dti-1335	7	18	of	of	ADP
dti-1335	7	19	neurological	neurological	ADJ
dti-1335	7	20	symptoms	symptom	NOUN
dti-1335	7	21	.	.	PUNCT
dti-1335	8	1	demyelination	demyelination	NOUN
dti-1335	8	2	also	also	ADV
dti-1335	8	3	provides	provide	VERB
dti-1335	8	4	a	a	DET
dti-1335	8	5	permitting	permitting	NOUN
dti-1335	8	6	condition	condition	NOUN
dti-1335	8	7	for	for	ADP
dti-1335	8	8	irreversible	irreversible	ADJ
dti-1335	8	9	axonal	axonal	ADJ
dti-1335	8	10	damage	damage	NOUN
dti-1335	8	11	.	.	PUNCT
dti-1335	9	1	remyelination	remyelination	NOUN
dti-1335	9	2	of	of	ADP
dti-1335	9	3	ms	ms	ADJ
dti-1335	9	4	lesions	lesion	NOUN
dti-1335	9	5	largely	largely	ADV
dti-1335	9	6	fails	fail	VERB
dti-1335	9	7	,	,	PUNCT
dti-1335	9	8	although	although	SCONJ
dti-1335	9	9	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	9	10	precursors	precursor	NOUN
dti-1335	9	11	and	and	CCONJ
dti-1335	9	12	premyelinating	premyelinate	VERB
dti-1335	9	13	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	9	14	(	(	PUNCT
dti-1335	9	15	myelin	myelin	NOUN
dti-1335	9	16	forming	form	VERB
dti-1335	9	17	cells	cell	NOUN
dti-1335	9	18	)	)	PUNCT
dti-1335	9	19	are	be	AUX
dti-1335	9	20	present	present	ADJ
dti-1335	9	21	in	in	ADP
dti-1335	9	22	many	many	ADJ
dti-1335	9	23	demyelinated	demyelinated	ADJ
dti-1335	9	24	plaques	plaque	NOUN
dti-1335	9	25	.	.	PUNCT
dti-1335	10	1	insulin	insulin	NOUN
dti-1335	10	2	-	-	PUNCT
dti-1335	10	3	like	like	ADJ
dti-1335	10	4	growth	growth	NOUN
dti-1335	10	5	factor	factor	NOUN
dti-1335	10	6	(	(	PUNCT
dti-1335	10	7	igf)-1	igf)-1	ADJ
dti-1335	10	8	is	be	AUX
dti-1335	10	9	a	a	DET
dti-1335	10	10	growth	growth	NOUN
dti-1335	10	11	factor	factor	NOUN
dti-1335	10	12	that	that	PRON
dti-1335	10	13	should	should	AUX
dti-1335	10	14	provide	provide	VERB
dti-1335	10	15	the	the	DET
dti-1335	10	16	appropriate	appropriate	ADJ
dti-1335	10	17	signals	signal	NOUN
dti-1335	10	18	to	to	PART
dti-1335	10	19	promote	promote	VERB
dti-1335	10	20	repair	repair	NOUN
dti-1335	10	21	of	of	ADP
dti-1335	10	22	ms	ms	ADJ
dti-1335	10	23	lesions	lesion	NOUN
dti-1335	10	24	,	,	PUNCT
dti-1335	10	25	because	because	SCONJ
dti-1335	10	26	it	it	PRON
dti-1335	10	27	acts	act	VERB
dti-1335	10	28	as	as	ADP
dti-1335	10	29	a	a	DET
dti-1335	10	30	survival	survival	NOUN
dti-1335	10	31	factor	factor	NOUN
dti-1335	10	32	for	for	ADP
dti-1335	10	33	cells	cell	NOUN
dti-1335	10	34	of	of	ADP
dti-1335	10	35	the	the	DET
dti-1335	10	36	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	10	37	lineage	lineage	NOUN
dti-1335	10	38	and	and	CCONJ
dti-1335	10	39	stimulates	stimulate	VERB
dti-1335	10	40	myelin	myelin	ADJ
dti-1335	10	41	synthesis	synthesis	NOUN
dti-1335	10	42	.	.	PUNCT
dti-1335	11	1	in	in	ADP
dti-1335	11	2	a	a	DET
dti-1335	11	3	pilot	pilot	NOUN
dti-1335	11	4	study	study	NOUN
dti-1335	11	5	on	on	ADP
dti-1335	11	6	ms	ms	ADJ
dti-1335	11	7	patients	patient	NOUN
dti-1335	11	8	,	,	PUNCT
dti-1335	11	9	no	no	DET
dti-1335	11	10	detectable	detectable	ADJ
dti-1335	11	11	remyelinating	remyelinating	NOUN
dti-1335	11	12	effects	effect	NOUN
dti-1335	11	13	in	in	ADP
dti-1335	11	14	the	the	DET
dti-1335	11	15	cns	cns	NOUN
dti-1335	11	16	were	be	AUX
dti-1335	11	17	observed	observe	VERB
dti-1335	11	18	following	follow	VERB
dti-1335	11	19	subcutaneous	subcutaneous	ADJ
dti-1335	11	20	administration	administration	NOUN
dti-1335	11	21	of	of	ADP
dti-1335	11	22	igf-1	igf-1	PRON
dti-1335	11	23	.	.	PUNCT
dti-1335	12	1	a	a	DET
dti-1335	12	2	number	number	NOUN
dti-1335	12	3	of	of	ADP
dti-1335	12	4	reasons	reason	NOUN
dti-1335	12	5	might	might	AUX
dti-1335	12	6	explain	explain	VERB
dti-1335	12	7	a	a	DET
dti-1335	12	8	lack	lack	NOUN
dti-1335	12	9	of	of	ADP
dti-1335	12	10	benefi	benefi	PROPN
dti-1335	12	11	cial	cial	ADJ
dti-1335	12	12	effects	effect	NOUN
dti-1335	12	13	:	:	PUNCT
dti-1335	12	14	a	a	X
dti-1335	12	15	)	)	PUNCT
dti-1335	12	16	it	it	PRON
dti-1335	12	17	is	be	AUX
dti-1335	12	18	unlikely	unlikely	ADJ
dti-1335	12	19	that	that	SCONJ
dti-1335	12	20	subcutaneous	subcutaneous	ADJ
dti-1335	12	21	administration	administration	NOUN
dti-1335	12	22	of	of	ADP
dti-1335	12	23	igf-1	igf-1	NOUN
dti-1335	12	24	provides	provide	VERB
dti-1335	12	25	suffi	suffi	NOUN
dti-1335	12	26	cient	cient	NOUN
dti-1335	12	27	passage	passage	NOUN
dti-1335	12	28	across	across	ADP
dti-1335	12	29	the	the	DET
dti-1335	12	30	blood	blood	NOUN
dti-1335	12	31	-	-	PUNCT
dti-1335	12	32	brain	brain	NOUN
dti-1335	12	33	-	-	PUNCT
dti-1335	12	34	barrier	barrier	NOUN
dti-1335	12	35	and	and	CCONJ
dti-1335	12	36	into	into	ADP
dti-1335	12	37	the	the	DET
dti-1335	12	38	cns	cns	NOUN
dti-1335	12	39	,	,	PUNCT
dti-1335	12	40	b	b	NOUN
dti-1335	12	41	)	)	PUNCT
dti-1335	12	42	the	the	DET
dti-1335	12	43	biological	biological	ADJ
dti-1335	12	44	actions	action	NOUN
dti-1335	12	45	of	of	ADP
dti-1335	12	46	igf-1	igf-1	NOUN
dti-1335	12	47	are	be	AUX
dti-1335	12	48	tightly	tightly	ADV
dti-1335	12	49	regulated	regulate	VERB
dti-1335	12	50	by	by	ADP
dti-1335	12	51	several	several	ADJ
dti-1335	12	52	insulin	insulin	NOUN
dti-1335	12	53	-	-	PUNCT
dti-1335	12	54	like	like	ADJ
dti-1335	12	55	growth	growth	NOUN
dti-1335	12	56	factor	factor	NOUN
dti-1335	12	57	binding	bind	VERB
dti-1335	12	58	proteins	protein	NOUN
dti-1335	12	59	(	(	PUNCT
dti-1335	12	60	igfbps	igfbps	NOUN
dti-1335	12	61	)	)	PUNCT
dti-1335	12	62	,	,	PUNCT
dti-1335	12	63	which	which	PRON
dti-1335	12	64	become	become	VERB
dti-1335	12	65	upregulated	upregulated	ADJ
dti-1335	12	66	in	in	ADP
dti-1335	12	67	the	the	DET
dti-1335	12	68	demyelinated	demyelinated	ADJ
dti-1335	12	69	lesions	lesion	NOUN
dti-1335	12	70	and	and	CCONJ
dti-1335	12	71	may	may	AUX
dti-1335	12	72	prevent	prevent	VERB
dti-1335	12	73	access	access	NOUN
dti-1335	12	74	of	of	ADP
dti-1335	12	75	igf-1	igf-1	NOUN
dti-1335	12	76	to	to	ADP
dti-1335	12	77	its	its	PRON
dti-1335	12	78	receptor	receptor	NOUN
dti-1335	12	79	,	,	PUNCT
dti-1335	12	80	c	c	NOUN
dti-1335	12	81	)	)	PUNCT
dti-1335	12	82	igf-1	igf-1	VERB
dti-1335	12	83	not	not	PART
dti-1335	12	84	only	only	ADV
dti-1335	12	85	acts	act	VERB
dti-1335	12	86	on	on	ADP
dti-1335	12	87	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	12	88	,	,	PUNCT
dti-1335	12	89	but	but	CCONJ
dti-1335	12	90	also	also	ADV
dti-1335	12	91	stimulates	stimulate	VERB
dti-1335	12	92	the	the	DET
dti-1335	12	93	proliferation	proliferation	NOUN
dti-1335	12	94	of	of	ADP
dti-1335	12	95	astrocytes	astrocyte	NOUN
dti-1335	12	96	,	,	PUNCT
dti-1335	12	97	which	which	PRON
dti-1335	12	98	form	form	VERB
dti-1335	12	99	the	the	DET
dti-1335	12	100	glial	glial	ADJ
dti-1335	12	101	scar	scar	NOUN
dti-1335	12	102	that	that	PRON
dti-1335	12	103	impedes	impede	VERB
dti-1335	12	104	repair	repair	NOUN
dti-1335	12	105	processes	process	NOUN
dti-1335	12	106	.	.	PUNCT
dti-1335	13	1	in	in	ADP
dti-1335	13	2	this	this	DET
dti-1335	13	3	review	review	NOUN
dti-1335	13	4	,	,	PUNCT
dti-1335	13	5	we	we	PRON
dti-1335	13	6	will	will	AUX
dti-1335	13	7	discuss	discuss	VERB
dti-1335	13	8	strategies	strategy	NOUN
dti-1335	13	9	to	to	PART
dti-1335	13	10	enhance	enhance	VERB
dti-1335	13	11	igf-1	igf-1	NOUN
dti-1335	13	12	signaling	signal	VERB
dti-1335	13	13	in	in	ADP
dti-1335	13	14	the	the	DET
dti-1335	13	15	cns	cns	NOUN
dti-1335	13	16	utilizing	utilize	VERB
dti-1335	13	17	a	a	DET
dti-1335	13	18	)	)	PUNCT
dti-1335	13	19	alternative	alternative	ADJ
dti-1335	13	20	routes	route	NOUN
dti-1335	13	21	of	of	ADP
dti-1335	13	22	administration	administration	NOUN
dti-1335	13	23	,	,	PUNCT
dti-1335	13	24	b	b	X
dti-1335	13	25	)	)	PUNCT
dti-1335	13	26	igf	igf	PROPN
dti-1335	13	27	analogues	analogue	NOUN
dti-1335	13	28	that	that	PRON
dti-1335	13	29	displace	displace	VERB
dti-1335	13	30	igf-1	igf-1	NOUN
dti-1335	13	31	from	from	ADP
dti-1335	13	32	regulatory	regulatory	ADJ
dti-1335	13	33	igfbps	igfbps	NOUN
dti-1335	13	34	and	and	CCONJ
dti-1335	13	35	c	c	NOUN
dti-1335	13	36	)	)	PUNCT
dti-1335	13	37	strategies	strategy	NOUN
dti-1335	13	38	to	to	PART
dti-1335	13	39	selectively	selectively	ADV
dti-1335	13	40	target	target	VERB
dti-1335	13	41	igf-1	igf-1	NOUN
dti-1335	13	42	to	to	ADP
dti-1335	13	43	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	13	44	.	.	PUNCT
dti-1335	14	1	keywords	keyword	NOUN
dti-1335	14	2	:	:	PUNCT
dti-1335	14	3	insulin	insulin	NOUN
dti-1335	14	4	-	-	PUNCT
dti-1335	14	5	like	like	ADJ
dti-1335	14	6	growth	growth	NOUN
dti-1335	14	7	factor	factor	NOUN
dti-1335	14	8	(	(	PUNCT
dti-1335	14	9	igf)-1	igf)-1	ADJ
dti-1335	14	10	,	,	PUNCT
dti-1335	14	11	igf-1	igf-1	NOUN
dti-1335	14	12	analogues	analogue	NOUN
dti-1335	14	13	,	,	PUNCT
dti-1335	14	14	igf	igf	NOUN
dti-1335	14	15	-	-	ADJ
dti-1335	14	16	binding	binding	ADJ
dti-1335	14	17	proteins	protein	NOUN
dti-1335	14	18	,	,	PUNCT
dti-1335	14	19	igfbp	igfbp	ADV
dti-1335	14	20	ligand	ligand	VERB
dti-1335	14	21	inhibitors	inhibitor	NOUN
dti-1335	14	22	,	,	PUNCT
dti-1335	14	23	micrornas	microrna	NOUN
dti-1335	14	24	,	,	PUNCT
dti-1335	14	25	multiple	multiple	ADJ
dti-1335	14	26	sclerosis	sclerosis	NOUN
dti-1335	14	27	introduction	introduction	NOUN
dti-1335	14	28	multiple	multiple	ADJ
dti-1335	14	29	sclerosis	sclerosis	NOUN
dti-1335	14	30	(	(	PUNCT
dti-1335	14	31	ms	ms	NOUN
dti-1335	14	32	)	)	PUNCT
dti-1335	14	33	is	be	AUX
dti-1335	14	34	a	a	DET
dti-1335	14	35	chronic	chronic	ADJ
dti-1335	14	36	multifocal	multifocal	ADJ
dti-1335	14	37	demyelinating	demyelinate	VERB
dti-1335	14	38	disease	disease	NOUN
dti-1335	14	39	of	of	ADP
dti-1335	14	40	the	the	DET
dti-1335	14	41	central	central	ADJ
dti-1335	14	42	nervous	nervous	ADJ
dti-1335	14	43	system	system	NOUN
dti-1335	14	44	(	(	PUNCT
dti-1335	14	45	cns	cns	NOUN
dti-1335	14	46	)	)	PUNCT
dti-1335	14	47	of	of	ADP
dti-1335	14	48	unknown	unknown	ADJ
dti-1335	14	49	etiology	etiology	NOUN
dti-1335	14	50	.	.	PUNCT
dti-1335	15	1	one	one	NUM
dti-1335	15	2	in	in	ADP
dti-1335	15	3	thousand	thousand	NUM
dti-1335	15	4	persons	person	NOUN
dti-1335	15	5	in	in	ADP
dti-1335	15	6	europe	europe	PROPN
dti-1335	15	7	are	be	AUX
dti-1335	15	8	affl	affl	NOUN
dti-1335	15	9	icted	icte	VERB
dti-1335	15	10	with	with	ADP
dti-1335	15	11	this	this	DET
dti-1335	15	12	disease	disease	NOUN
dti-1335	15	13	which	which	PRON
dti-1335	15	14	generally	generally	ADV
dti-1335	15	15	occurs	occur	VERB
dti-1335	15	16	between	between	ADP
dti-1335	15	17	the	the	DET
dti-1335	15	18	ages	age	NOUN
dti-1335	15	19	of	of	ADP
dti-1335	15	20	30–40	30–40	NUM
dti-1335	15	21	(	(	PUNCT
dti-1335	15	22	noseworthy	noseworthy	NOUN
dti-1335	15	23	et	et	PROPN
dti-1335	15	24	al	al	PROPN
dti-1335	15	25	.	.	PROPN
dti-1335	15	26	2000	2000	NUM
dti-1335	15	27	)	)	PUNCT
dti-1335	15	28	.	.	PUNCT
dti-1335	16	1	pathological	pathological	ADJ
dti-1335	16	2	hallmarks	hallmark	NOUN
dti-1335	16	3	of	of	ADP
dti-1335	16	4	ms	ms	PROPN
dti-1335	16	5	are	be	AUX
dti-1335	16	6	infl	infl	PROPN
dti-1335	16	7	ammation	ammation	PROPN
dti-1335	16	8	,	,	PUNCT
dti-1335	16	9	demyelination	demyelination	NOUN
dti-1335	16	10	,	,	PUNCT
dti-1335	16	11	degeneration	degeneration	NOUN
dti-1335	16	12	and	and	CCONJ
dti-1335	16	13	loss	loss	NOUN
dti-1335	16	14	of	of	ADP
dti-1335	16	15	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	16	16	,	,	PUNCT
dti-1335	16	17	proliferation	proliferation	NOUN
dti-1335	16	18	of	of	ADP
dti-1335	16	19	astrocytes	astrocyte	NOUN
dti-1335	16	20	,	,	PUNCT
dti-1335	16	21	and	and	CCONJ
dti-1335	16	22	axonal	axonal	ADJ
dti-1335	16	23	damage	damage	NOUN
dti-1335	16	24	in	in	ADP
dti-1335	16	25	the	the	DET
dti-1335	16	26	cns	cns	PROPN
dti-1335	16	27	(	(	PUNCT
dti-1335	16	28	wolswijk	wolswijk	NOUN
dti-1335	16	29	,	,	PUNCT
dti-1335	16	30	2000	2000	NUM
dti-1335	16	31	)	)	PUNCT
dti-1335	16	32	.	.	PUNCT
dti-1335	17	1	figure	figure	NOUN
dti-1335	17	2	1	1	NUM
dti-1335	17	3	shows	show	VERB
dti-1335	17	4	a	a	DET
dti-1335	17	5	chronic	chronic	ADJ
dti-1335	17	6	ms	ms	NOUN
dti-1335	17	7	lesion	lesion	NOUN
dti-1335	17	8	,	,	PUNCT
dti-1335	17	9	characterized	characterize	VERB
dti-1335	17	10	by	by	ADP
dti-1335	17	11	demyelination	demyelination	NOUN
dti-1335	17	12	and	and	CCONJ
dti-1335	17	13	astrogliosis	astrogliosis	NOUN
dti-1335	17	14	.	.	PUNCT
dti-1335	18	1	the	the	DET
dti-1335	18	2	underlying	underlie	VERB
dti-1335	18	3	cause	cause	NOUN
dti-1335	18	4	of	of	ADP
dti-1335	18	5	myelin	myelin	ADJ
dti-1335	18	6	destruction	destruction	NOUN
dti-1335	18	7	and	and	CCONJ
dti-1335	18	8	death	death	NOUN
dti-1335	18	9	of	of	ADP
dti-1335	18	10	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	18	11	in	in	ADP
dti-1335	18	12	ms	ms	PROPN
dti-1335	18	13	is	be	AUX
dti-1335	18	14	not	not	PART
dti-1335	18	15	completely	completely	ADV
dti-1335	18	16	understood	understand	VERB
dti-1335	18	17	,	,	PUNCT
dti-1335	18	18	however	however	SCONJ
dti-1335	18	19	data	datum	NOUN
dti-1335	18	20	suggest	suggest	VERB
dti-1335	18	21	that	that	SCONJ
dti-1335	18	22	ms	ms	PROPN
dti-1335	18	23	may	may	AUX
dti-1335	18	24	be	be	AUX
dti-1335	18	25	a	a	DET
dti-1335	18	26	disease	disease	NOUN
dti-1335	18	27	of	of	ADP
dti-1335	18	28	autoimmune	autoimmune	ADJ
dti-1335	18	29	nature	nature	NOUN
dti-1335	18	30	(	(	PUNCT
dti-1335	18	31	steinman	steinman	NOUN
dti-1335	18	32	,	,	PUNCT
dti-1335	18	33	1996	1996	NUM
dti-1335	18	34	)	)	PUNCT
dti-1335	18	35	.	.	PUNCT
dti-1335	19	1	disruption	disruption	NOUN
dti-1335	19	2	of	of	ADP
dti-1335	19	3	the	the	DET
dti-1335	19	4	myelin	myelin	ADJ
dti-1335	19	5	sheaths	sheath	NOUN
dti-1335	19	6	,	,	PUNCT
dti-1335	19	7	axonal	axonal	ADJ
dti-1335	19	8	injury	injury	NOUN
dti-1335	19	9	and	and	CCONJ
dti-1335	19	10	glial	glial	ADJ
dti-1335	19	11	scar	scar	NOUN
dti-1335	19	12	formation	formation	NOUN
dti-1335	19	13	is	be	AUX
dti-1335	19	14	responsible	responsible	ADJ
dti-1335	19	15	for	for	ADP
dti-1335	19	16	the	the	DET
dti-1335	19	17	clinical	clinical	ADJ
dti-1335	19	18	symptoms	symptom	NOUN
dti-1335	19	19	that	that	PRON
dti-1335	19	20	accumulate	accumulate	VERB
dti-1335	19	21	in	in	ADP
dti-1335	19	22	the	the	DET
dti-1335	19	23	course	course	NOUN
dti-1335	19	24	of	of	ADP
dti-1335	19	25	disease	disease	NOUN
dti-1335	19	26	.	.	PUNCT
dti-1335	20	1	for	for	ADP
dti-1335	20	2	a	a	DET
dti-1335	20	3	disease	disease	NOUN
dti-1335	20	4	with	with	ADP
dti-1335	20	5	such	such	DET
dti-1335	20	6	a	a	DET
dti-1335	20	7	high	high	ADJ
dti-1335	20	8	impact	impact	NOUN
dti-1335	20	9	,	,	PUNCT
dti-1335	20	10	the	the	DET
dti-1335	20	11	present	present	ADJ
dti-1335	20	12	therapeutic	therapeutic	ADJ
dti-1335	20	13	options	option	NOUN
dti-1335	20	14	are	be	AUX
dti-1335	20	15	disappointing	disappointing	ADJ
dti-1335	20	16	with	with	ADP
dti-1335	20	17	restricted	restricted	ADJ
dti-1335	20	18	clinical	clinical	ADJ
dti-1335	20	19	benefi	benefi	NOUN
dti-1335	20	20	ts	ts	PROPN
dti-1335	20	21	.	.	PUNCT
dti-1335	21	1	in	in	ADP
dti-1335	21	2	order	order	NOUN
dti-1335	21	3	to	to	PART
dti-1335	21	4	prevent	prevent	VERB
dti-1335	21	5	further	further	ADJ
dti-1335	21	6	damage	damage	NOUN
dti-1335	21	7	from	from	ADP
dti-1335	21	8	occurring	occur	VERB
dti-1335	21	9	in	in	ADP
dti-1335	21	10	the	the	DET
dti-1335	21	11	cns	cns	NOUN
dti-1335	21	12	,	,	PUNCT
dti-1335	21	13	current	current	ADJ
dti-1335	21	14	therapies	therapy	NOUN
dti-1335	21	15	target	target	VERB
dti-1335	21	16	the	the	DET
dti-1335	21	17	immune	immune	ADJ
dti-1335	21	18	system	system	NOUN
dti-1335	21	19	and	and	CCONJ
dti-1335	21	20	are	be	AUX
dti-1335	21	21	aimed	aim	VERB
dti-1335	21	22	at	at	ADP
dti-1335	21	23	reducing	reduce	VERB
dti-1335	21	24	relapses	relapse	NOUN
dti-1335	21	25	,	,	PUNCT
dti-1335	21	26	which	which	PRON
dti-1335	21	27	are	be	AUX
dti-1335	21	28	caused	cause	VERB
dti-1335	21	29	by	by	ADP
dti-1335	21	30	the	the	DET
dti-1335	21	31	formation	formation	NOUN
dti-1335	21	32	of	of	ADP
dti-1335	21	33	new	new	ADJ
dti-1335	21	34	demyelinating	demyelinate	VERB
dti-1335	21	35	lesions	lesion	NOUN
dti-1335	21	36	.	.	PUNCT
dti-1335	22	1	current	current	ADJ
dti-1335	22	2	immunomodulatory	immunomodulatory	ADJ
dti-1335	22	3	therapies	therapy	NOUN
dti-1335	22	4	,	,	PUNCT
dti-1335	22	5	including	include	VERB
dti-1335	22	6	interferon	interferon	ADJ
dti-1335	22	7	-	-	PUNCT
dti-1335	22	8	γ	γ	NOUN
dti-1335	22	9	(	(	PUNCT
dti-1335	22	10	fillipini	fillipini	NOUN
dti-1335	22	11	et	et	PROPN
dti-1335	22	12	al	al	PROPN
dti-1335	22	13	.	.	PROPN
dti-1335	22	14	2003	2003	NUM
dti-1335	22	15	)	)	PUNCT
dti-1335	22	16	and	and	CCONJ
dti-1335	22	17	glatiramer	glatiramer	ADJ
dti-1335	22	18	acetate	acetate	NOUN
dti-1335	22	19	,	,	PUNCT
dti-1335	22	20	show	show	VERB
dti-1335	22	21	only	only	ADV
dti-1335	22	22	a	a	DET
dti-1335	22	23	modest	modest	ADJ
dti-1335	22	24	protective	protective	ADJ
dti-1335	22	25	effect	effect	NOUN
dti-1335	22	26	against	against	ADP
dti-1335	22	27	relapses	relapse	NOUN
dti-1335	22	28	.	.	PUNCT
dti-1335	23	1	therapies	therapy	NOUN
dti-1335	23	2	directed	direct	VERB
dti-1335	23	3	at	at	ADP
dti-1335	23	4	repairing	repair	VERB
dti-1335	23	5	damage	damage	NOUN
dti-1335	23	6	,	,	PUNCT
dti-1335	23	7	e.g.	e.g.	ADV
dti-1335	23	8	based	base	VERB
dti-1335	23	9	on	on	ADP
dti-1335	23	10	remyelination	remyelination	NOUN
dti-1335	23	11	strategies	strategy	NOUN
dti-1335	23	12	,	,	PUNCT
dti-1335	23	13	have	have	AUX
dti-1335	23	14	not	not	PART
dti-1335	23	15	yet	yet	ADV
dti-1335	23	16	been	be	AUX
dti-1335	23	17	developed	develop	VERB
dti-1335	23	18	.	.	PUNCT
dti-1335	24	1	following	follow	VERB
dti-1335	24	2	demyelination	demyelination	NOUN
dti-1335	24	3	,	,	PUNCT
dti-1335	24	4	some	some	DET
dti-1335	24	5	remyelination	remyelination	NOUN
dti-1335	24	6	of	of	ADP
dti-1335	24	7	ms	ms	ADJ
dti-1335	24	8	lesions	lesion	NOUN
dti-1335	24	9	can	can	AUX
dti-1335	24	10	be	be	AUX
dti-1335	24	11	observed	observe	VERB
dti-1335	24	12	during	during	ADP
dti-1335	24	13	the	the	DET
dti-1335	24	14	early	early	ADJ
dti-1335	24	15	stages	stage	NOUN
dti-1335	24	16	of	of	ADP
dti-1335	24	17	the	the	DET
dti-1335	24	18	disease	disease	NOUN
dti-1335	24	19	(	(	PUNCT
dti-1335	24	20	prineas	prineas	ADP
dti-1335	24	21	et	et	PROPN
dti-1335	24	22	al	al	PROPN
dti-1335	24	23	.	.	PROPN
dti-1335	24	24	1993	1993	NUM
dti-1335	24	25	)	)	PUNCT
dti-1335	24	26	,	,	PUNCT
dti-1335	24	27	although	although	SCONJ
dti-1335	24	28	this	this	PRON
dti-1335	24	29	is	be	AUX
dti-1335	24	30	often	often	ADV
dti-1335	24	31	limited	limit	VERB
dti-1335	24	32	in	in	ADP
dti-1335	24	33	its	its	PRON
dti-1335	24	34	extent	extent	NOUN
dti-1335	24	35	,	,	PUNCT
dti-1335	24	36	and	and	CCONJ
dti-1335	24	37	largely	largely	ADV
dti-1335	24	38	fails	fail	VERB
dti-1335	24	39	as	as	SCONJ
dti-1335	24	40	the	the	DET
dti-1335	24	41	disease	disease	NOUN
dti-1335	24	42	progresses	progress	VERB
dti-1335	24	43	.	.	PUNCT
dti-1335	25	1	most	most	ADJ
dti-1335	25	2	chronic	chronic	ADJ
dti-1335	25	3	lesions	lesion	NOUN
dti-1335	25	4	of	of	ADP
dti-1335	25	5	ms	ms	PROPN
dti-1335	25	6	demonstrate	demonstrate	VERB
dti-1335	25	7	no	no	DET
dti-1335	25	8	remyelination	remyelination	NOUN
dti-1335	25	9	,	,	PUNCT
dti-1335	25	10	although	although	SCONJ
dti-1335	25	11	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	25	12	precursor	precursor	NOUN
dti-1335	25	13	cells	cell	NOUN
dti-1335	25	14	and	and	CCONJ
dti-1335	25	15	premyelinating	premyelinate	VERB
dti-1335	25	16	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	25	17	are	be	AUX
dti-1335	25	18	present	present	ADJ
dti-1335	25	19	in	in	ADP
dti-1335	25	20	many	many	ADJ
dti-1335	25	21	demyelinated	demyelinated	ADJ
dti-1335	25	22	plaques	plaque	NOUN
dti-1335	25	23	(	(	PUNCT
dti-1335	25	24	chang	chang	PROPN
dti-1335	25	25	et	et	PROPN
dti-1335	25	26	al	al	PROPN
dti-1335	25	27	.	.	PROPN
dti-1335	25	28	2002	2002	NUM
dti-1335	25	29	;	;	PUNCT
dti-1335	25	30	scolding	scold	VERB
dti-1335	25	31	et	et	PROPN
dti-1335	25	32	al	al	PROPN
dti-1335	25	33	.	.	PROPN
dti-1335	25	34	1998	1998	NUM
dti-1335	25	35	;	;	PUNCT
dti-1335	25	36	wolswijk	wolswijk	NOUN
dti-1335	25	37	,	,	PUNCT
dti-1335	25	38	2002	2002	NUM
dti-1335	25	39	)	)	PUNCT
dti-1335	25	40	.	.	PUNCT
dti-1335	26	1	this	this	PRON
dti-1335	26	2	suggests	suggest	VERB
dti-1335	26	3	that	that	SCONJ
dti-1335	26	4	the	the	DET
dti-1335	26	5	microenvironment	microenvironment	NOUN
dti-1335	26	6	in	in	ADP
dti-1335	26	7	chronic	chronic	ADJ
dti-1335	26	8	ms	ms	PROPN
dti-1335	26	9	lesions	lesion	NOUN
dti-1335	26	10	may	may	AUX
dti-1335	26	11	possess	possess	VERB
dti-1335	26	12	the	the	DET
dti-1335	26	13	potential	potential	NOUN
dti-1335	26	14	for	for	ADP
dti-1335	26	15	remyelination	remyelination	NOUN
dti-1335	26	16	,	,	PUNCT
dti-1335	26	17	yet	yet	CCONJ
dti-1335	26	18	failure	failure	NOUN
dti-1335	26	19	of	of	ADP
dti-1335	26	20	this	this	DET
dti-1335	26	21	event	event	NOUN
dti-1335	26	22	is	be	AUX
dti-1335	26	23	likely	likely	ADJ
dti-1335	26	24	due	due	ADP
dti-1335	26	25	to	to	ADP
dti-1335	26	26	a	a	DET
dti-1335	26	27	lack	lack	NOUN
dti-1335	26	28	of	of	ADP
dti-1335	26	29	appropriate	appropriate	ADJ
dti-1335	26	30	signals	signal	NOUN
dti-1335	26	31	to	to	PART
dti-1335	26	32	stimulate	stimulate	VERB
dti-1335	26	33	remyelination	remyelination	NOUN
dti-1335	26	34	.	.	PUNCT
dti-1335	27	1	reduced	reduce	VERB
dti-1335	27	2	(	(	PUNCT
dti-1335	27	3	neuro	neuro	NOUN
dti-1335	27	4	)	)	PUNCT
dti-1335	27	5	trophic	trophic	ADJ
dti-1335	27	6	support	support	NOUN
dti-1335	27	7	to	to	ADP
dti-1335	27	8	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1335	27	9	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1335	27	10	38	38	NUM
dti-1335	27	11	wilczak	wilczak	NOUN
dti-1335	27	12	et	et	PROPN
dti-1335	27	13	al	al	PROPN
dti-1335	27	14	drug	drug	PROPN
dti-1335	27	15	target	target	NOUN
dti-1335	27	16	insights	insight	NOUN
dti-1335	27	17	2008:3	2008:3	NUM
dti-1335	27	18	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	27	19	might	might	AUX
dti-1335	27	20	be	be	AUX
dti-1335	27	21	implicated	implicate	VERB
dti-1335	27	22	in	in	ADP
dti-1335	27	23	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	27	24	apoptosis	apoptosis	NOUN
dti-1335	27	25	and	and	CCONJ
dti-1335	27	26	the	the	DET
dti-1335	27	27	failure	failure	NOUN
dti-1335	27	28	of	of	ADP
dti-1335	27	29	remyelination	remyelination	NOUN
dti-1335	27	30	in	in	ADP
dti-1335	27	31	ms	ms	PROPN
dti-1335	27	32	.	.	PROPN
dti-1335	27	33	insulin	insulin	PROPN
dti-1335	27	34	-	-	PUNCT
dti-1335	27	35	like	like	ADJ
dti-1335	27	36	growth	growth	NOUN
dti-1335	27	37	factor	factor	NOUN
dti-1335	27	38	(	(	PUNCT
dti-1335	27	39	igf)-1	igf)-1	ADJ
dti-1335	27	40	is	be	AUX
dti-1335	27	41	a	a	DET
dti-1335	27	42	(	(	PUNCT
dti-1335	27	43	neuro)trophic	neuro)trophic	ADJ
dti-1335	27	44	growth	growth	NOUN
dti-1335	27	45	factor	factor	NOUN
dti-1335	27	46	with	with	ADP
dti-1335	27	47	insulin	insulin	NOUN
dti-1335	27	48	-	-	PUNCT
dti-1335	27	49	like	like	ADJ
dti-1335	27	50	metabolic	metabolic	NOUN
dti-1335	27	51	activities	activity	NOUN
dti-1335	27	52	which	which	PRON
dti-1335	27	53	possesses	possess	VERB
dti-1335	27	54	potential	potential	ADJ
dti-1335	27	55	clinical	clinical	ADJ
dti-1335	27	56	applications	application	NOUN
dti-1335	27	57	,	,	PUNCT
dti-1335	27	58	particularly	particularly	ADV
dti-1335	27	59	in	in	ADP
dti-1335	27	60	(	(	PUNCT
dti-1335	27	61	neuro	neuro	NOUN
dti-1335	27	62	)	)	PUNCT
dti-1335	27	63	degenerative	degenerative	ADJ
dti-1335	27	64	disorders	disorder	NOUN
dti-1335	27	65	of	of	ADP
dti-1335	27	66	the	the	DET
dti-1335	27	67	cns	cns	NOUN
dti-1335	27	68	.	.	PUNCT
dti-1335	28	1	short	short	ADJ
dti-1335	28	2	overview	overview	NOUN
dti-1335	28	3	of	of	ADP
dti-1335	28	4	the	the	DET
dti-1335	28	5	igf	igf	PROPN
dti-1335	28	6	system	system	NOUN
dti-1335	28	7	the	the	DET
dti-1335	28	8	components	component	NOUN
dti-1335	28	9	of	of	ADP
dti-1335	28	10	the	the	DET
dti-1335	28	11	igf	igf	PROPN
dti-1335	28	12	system	system	NOUN
dti-1335	28	13	include	include	VERB
dti-1335	28	14	igf-1	igf-1	NOUN
dti-1335	28	15	and	and	CCONJ
dti-1335	28	16	-2	-2	INTJ
dti-1335	28	17	(	(	PUNCT
dti-1335	28	18	igfs	igfs	PROPN
dti-1335	28	19	)	)	PUNCT
dti-1335	28	20	,	,	PUNCT
dti-1335	28	21	type-1	type-1	PROPN
dti-1335	28	22	and	and	CCONJ
dti-1335	28	23	-2	-2	NOUN
dti-1335	28	24	igf	igf	NOUN
dti-1335	28	25	receptors	receptor	NOUN
dti-1335	28	26	and	and	CCONJ
dti-1335	28	27	six	six	NUM
dti-1335	28	28	insulin	insulin	NOUN
dti-1335	28	29	-	-	PUNCT
dti-1335	28	30	like	like	ADJ
dti-1335	28	31	growth	growth	NOUN
dti-1335	28	32	factor	factor	NOUN
dti-1335	28	33	binding	bind	VERB
dti-1335	28	34	proteins	protein	NOUN
dti-1335	28	35	(	(	PUNCT
dti-1335	28	36	igfbps	igfbps	NOUN
dti-1335	28	37	)	)	PUNCT
dti-1335	28	38	.	.	PUNCT
dti-1335	29	1	in	in	ADP
dti-1335	29	2	the	the	DET
dti-1335	29	3	cns	cns	NOUN
dti-1335	29	4	,	,	PUNCT
dti-1335	29	5	both	both	DET
dti-1335	29	6	igf-1	igf-1	NOUN
dti-1335	29	7	and	and	CCONJ
dti-1335	29	8	-2	-2	NOUN
dti-1335	29	9	are	be	AUX
dti-1335	29	10	produced	produce	VERB
dti-1335	29	11	as	as	ADP
dti-1335	29	12	paracrine	paracrine	NOUN
dti-1335	29	13	and	and	CCONJ
dti-1335	29	14	autocrine	autocrine	NOUN
dti-1335	29	15	hormones	hormone	NOUN
dti-1335	29	16	.	.	PUNCT
dti-1335	30	1	igf-2	igf-2	PUNCT
dti-1335	30	2	is	be	AUX
dti-1335	30	3	genetically	genetically	ADV
dti-1335	30	4	related	relate	VERB
dti-1335	30	5	to	to	ADP
dti-1335	30	6	igf-1	igf-1	NOUN
dti-1335	30	7	and	and	CCONJ
dti-1335	30	8	both	both	DET
dti-1335	30	9	hormones	hormone	NOUN
dti-1335	30	10	display	display	VERB
dti-1335	30	11	approximately	approximately	ADV
dti-1335	30	12	62	62	NUM
dti-1335	30	13	percent	percent	NOUN
dti-1335	30	14	sequence	sequence	NOUN
dti-1335	30	15	homology	homology	NOUN
dti-1335	30	16	.	.	PUNCT
dti-1335	31	1	whereas	whereas	SCONJ
dti-1335	31	2	igf-1	igf-1	NOUN
dti-1335	31	3	expression	expression	NOUN
dti-1335	31	4	in	in	ADP
dti-1335	31	5	the	the	DET
dti-1335	31	6	cns	cns	NOUN
dti-1335	31	7	is	be	AUX
dti-1335	31	8	high	high	ADJ
dti-1335	31	9	in	in	ADP
dti-1335	31	10	neuronal	neuronal	ADJ
dti-1335	31	11	rich	rich	ADJ
dti-1335	31	12	regions	region	NOUN
dti-1335	31	13	of	of	ADP
dti-1335	31	14	the	the	DET
dti-1335	31	15	brain	brain	NOUN
dti-1335	31	16	(	(	PUNCT
dti-1335	31	17	bondy	bondy	PROPN
dti-1335	31	18	et	et	PROPN
dti-1335	31	19	al	al	PROPN
dti-1335	31	20	.	.	PROPN
dti-1335	31	21	1992	1992	NUM
dti-1335	31	22	)	)	PUNCT
dti-1335	31	23	,	,	PUNCT
dti-1335	31	24	igf-2	igf-2	PUNCT
dti-1335	31	25	is	be	AUX
dti-1335	31	26	highly	highly	ADV
dti-1335	31	27	expressed	express	VERB
dti-1335	31	28	in	in	ADP
dti-1335	31	29	mesenchymal	mesenchymal	NOUN
dti-1335	31	30	support	support	NOUN
dti-1335	31	31	structures	structure	NOUN
dti-1335	31	32	of	of	ADP
dti-1335	31	33	the	the	DET
dti-1335	31	34	cns	cns	NOUN
dti-1335	31	35	,	,	PUNCT
dti-1335	31	36	including	include	VERB
dti-1335	31	37	the	the	DET
dti-1335	31	38	choroid	choroid	NOUN
dti-1335	31	39	plexus	plexus	NOUN
dti-1335	31	40	(	(	PUNCT
dti-1335	31	41	logan	logan	PROPN
dti-1335	31	42	et	et	PROPN
dti-1335	31	43	al	al	PROPN
dti-1335	31	44	.	.	PROPN
dti-1335	31	45	1994	1994	NUM
dti-1335	31	46	)	)	PUNCT
dti-1335	31	47	.	.	PUNCT
dti-1335	32	1	biological	biological	ADJ
dti-1335	32	2	actions	action	NOUN
dti-1335	32	3	of	of	ADP
dti-1335	32	4	these	these	DET
dti-1335	32	5	growth	growth	NOUN
dti-1335	32	6	factors	factor	NOUN
dti-1335	32	7	on	on	ADP
dti-1335	32	8	target	target	NOUN
dti-1335	32	9	cells	cell	NOUN
dti-1335	32	10	are	be	AUX
dti-1335	32	11	mediated	mediate	VERB
dti-1335	32	12	by	by	ADP
dti-1335	32	13	cell	cell	NOUN
dti-1335	32	14	-	-	PUNCT
dti-1335	32	15	surface	surface	NOUN
dti-1335	32	16	receptors	receptor	NOUN
dti-1335	32	17	.	.	PUNCT
dti-1335	33	1	two	two	NUM
dti-1335	33	2	types	type	NOUN
dti-1335	33	3	of	of	ADP
dti-1335	33	4	igf	igf	NOUN
dti-1335	33	5	receptors	receptor	NOUN
dti-1335	33	6	have	have	AUX
dti-1335	33	7	been	be	AUX
dti-1335	33	8	identifi	identifi	PROPN
dti-1335	33	9	ed	ed	NOUN
dti-1335	33	10	in	in	ADP
dti-1335	33	11	human	human	ADJ
dti-1335	33	12	brain	brain	NOUN
dti-1335	33	13	,	,	PUNCT
dti-1335	33	14	the	the	DET
dti-1335	33	15	type-1	type-1	PROPN
dti-1335	33	16	and	and	CCONJ
dti-1335	33	17	type-2	type-2	NUM
dti-1335	33	18	igf	igf	NOUN
dti-1335	33	19	receptor	receptor	NOUN
dti-1335	33	20	.	.	PUNCT
dti-1335	34	1	the	the	DET
dti-1335	34	2	type-1	type-1	PROPN
dti-1335	34	3	igf	igf	NOUN
dti-1335	34	4	receptor	receptor	NOUN
dti-1335	34	5	is	be	AUX
dti-1335	34	6	a	a	DET
dti-1335	34	7	membrane	membrane	NOUN
dti-1335	34	8	glycoprotein	glycoprotein	NOUN
dti-1335	34	9	consisting	consist	VERB
dti-1335	34	10	of	of	ADP
dti-1335	34	11	two	two	NUM
dti-1335	34	12	α	α	NOUN
dti-1335	34	13	-	-	PUNCT
dti-1335	34	14	subunits	subunit	NOUN
dti-1335	34	15	and	and	CCONJ
dti-1335	34	16	two	two	NUM
dti-1335	34	17	β	β	NOUN
dti-1335	34	18	-	-	NOUN
dti-1335	34	19	subunits	subunit	NOUN
dti-1335	34	20	(	(	PUNCT
dti-1335	34	21	yamasaki	yamasaki	PROPN
dti-1335	34	22	et	et	PROPN
dti-1335	34	23	al	al	PROPN
dti-1335	34	24	.	.	PROPN
dti-1335	34	25	1993	1993	NUM
dti-1335	34	26	)	)	PUNCT
dti-1335	34	27	.	.	PUNCT
dti-1335	35	1	the	the	DET
dti-1335	35	2	α	α	NOUN
dti-1335	35	3	-	-	PUNCT
dti-1335	35	4	subunit	subunit	NOUN
dti-1335	35	5	is	be	AUX
dti-1335	35	6	entirely	entirely	ADV
dti-1335	35	7	extracellular	extracellular	ADJ
dti-1335	35	8	and	and	CCONJ
dti-1335	35	9	contains	contain	VERB
dti-1335	35	10	the	the	DET
dti-1335	35	11	ligandbinding	ligandbinde	VERB
dti-1335	35	12	site	site	NOUN
dti-1335	35	13	.	.	PUNCT
dti-1335	36	1	the	the	DET
dti-1335	36	2	β	β	NOUN
dti-1335	36	3	-	-	PUNCT
dti-1335	36	4	subunit	subunit	NOUN
dti-1335	36	5	contains	contain	VERB
dti-1335	36	6	a	a	DET
dti-1335	36	7	transmembrane	transmembrane	ADJ
dti-1335	36	8	domain	domain	NOUN
dti-1335	36	9	with	with	ADP
dti-1335	36	10	a	a	DET
dti-1335	36	11	short	short	ADJ
dti-1335	36	12	extracellular	extracellular	ADJ
dti-1335	36	13	region	region	NOUN
dti-1335	36	14	,	,	PUNCT
dti-1335	36	15	and	and	CCONJ
dti-1335	36	16	a	a	DET
dti-1335	36	17	tyrosine	tyrosine	NOUN
dti-1335	36	18	kinase	kinase	NOUN
dti-1335	36	19	domain	domain	NOUN
dti-1335	36	20	in	in	ADP
dti-1335	36	21	its	its	PRON
dti-1335	36	22	cytoplasmic	cytoplasmic	ADJ
dti-1335	36	23	portion	portion	NOUN
dti-1335	36	24	.	.	PUNCT
dti-1335	37	1	the	the	DET
dti-1335	37	2	type-2	type-2	NUM
dti-1335	37	3	igf	igf	PROPN
dti-1335	37	4	receptor	receptor	NOUN
dti-1335	37	5	is	be	AUX
dti-1335	37	6	structurally	structurally	ADV
dti-1335	37	7	and	and	CCONJ
dti-1335	37	8	functionally	functionally	ADV
dti-1335	37	9	quite	quite	ADV
dti-1335	37	10	different	different	ADJ
dti-1335	37	11	from	from	ADP
dti-1335	37	12	the	the	DET
dti-1335	37	13	type-1	type-1	PROPN
dti-1335	37	14	igf	igf	NOUN
dti-1335	37	15	receptor	receptor	NOUN
dti-1335	37	16	.	.	PUNCT
dti-1335	38	1	the	the	DET
dti-1335	38	2	type-2	type-2	NUM
dti-1335	38	3	igf	igf	PROPN
dti-1335	38	4	receptor	receptor	NOUN
dti-1335	38	5	consists	consist	VERB
dti-1335	38	6	of	of	ADP
dti-1335	38	7	a	a	DET
dti-1335	38	8	single	single	ADJ
dti-1335	38	9	glycosylated	glycosylated	ADJ
dti-1335	38	10	polypeptide	polypeptide	NOUN
dti-1335	38	11	.	.	PUNCT
dti-1335	39	1	the	the	DET
dti-1335	39	2	type-2	type-2	NUM
dti-1335	39	3	igf	igf	PROPN
dti-1335	39	4	receptor	receptor	NOUN
dti-1335	39	5	lies	lie	VERB
dti-1335	39	6	primarily	primarily	ADV
dti-1335	39	7	extracellular	extracellular	ADJ
dti-1335	39	8	with	with	ADP
dti-1335	39	9	a	a	DET
dti-1335	39	10	short	short	ADJ
dti-1335	39	11	cytoplasmic	cytoplasmic	ADJ
dti-1335	39	12	tail	tail	NOUN
dti-1335	39	13	and	and	CCONJ
dti-1335	39	14	consists	consist	VERB
dti-1335	39	15	of	of	ADP
dti-1335	39	16	15	15	NUM
dti-1335	39	17	repeated	repeat	VERB
dti-1335	39	18	mannose6	mannose6	NOUN
dti-1335	39	19	-	-	NOUN
dti-1335	39	20	phosphate	phosphate	ADJ
dti-1335	39	21	(	(	PUNCT
dti-1335	39	22	m6p)-binding	m6p)-binding	NOUN
dti-1335	39	23	units	unit	NOUN
dti-1335	39	24	(	(	PUNCT
dti-1335	39	25	kornfeld	kornfeld	PROPN
dti-1335	39	26	et	et	PROPN
dti-1335	39	27	al	al	PROPN
dti-1335	39	28	.	.	PROPN
dti-1335	39	29	1992	1992	NUM
dti-1335	39	30	)	)	PUNCT
dti-1335	39	31	.	.	PUNCT
dti-1335	40	1	the	the	DET
dti-1335	40	2	major	major	ADJ
dti-1335	40	3	functions	function	NOUN
dti-1335	40	4	of	of	ADP
dti-1335	40	5	the	the	DET
dti-1335	40	6	type-2	type-2	NUM
dti-1335	40	7	igf	igf	PROPN
dti-1335	40	8	receptor	receptor	NOUN
dti-1335	40	9	binding	bind	VERB
dti-1335	40	10	appear	appear	VERB
dti-1335	40	11	to	to	PART
dti-1335	40	12	be	be	AUX
dti-1335	40	13	lysosomal	lysosomal	ADJ
dti-1335	40	14	enzyme	enzyme	NOUN
dti-1335	40	15	traffi	traffi	NOUN
dti-1335	40	16	cking	cking	ADJ
dti-1335	40	17	(	(	PUNCT
dti-1335	40	18	kornfeld	kornfeld	PROPN
dti-1335	40	19	et	et	PROPN
dti-1335	40	20	al	al	PROPN
dti-1335	40	21	.	.	PROPN
dti-1335	40	22	1992	1992	NUM
dti-1335	40	23	)	)	PUNCT
dti-1335	40	24	and	and	CCONJ
dti-1335	40	25	igf-2	igf-2	PUNCT
dti-1335	40	26	degradation	degradation	NOUN
dti-1335	40	27	via	via	ADP
dti-1335	40	28	receptor	receptor	NOUN
dti-1335	40	29	mediated	mediate	VERB
dti-1335	40	30	-	-	PUNCT
dti-1335	40	31	internalization	internalization	NOUN
dti-1335	40	32	(	(	PUNCT
dti-1335	40	33	morgan	morgan	PROPN
dti-1335	40	34	et	et	PROPN
dti-1335	40	35	al	al	PROPN
dti-1335	40	36	.	.	PROPN
dti-1335	40	37	1987	1987	NUM
dti-1335	40	38	)	)	PUNCT
dti-1335	40	39	.	.	PUNCT
dti-1335	41	1	type-2	type-2	NUM
dti-1335	41	2	igf	igf	NOUN
dti-1335	41	3	receptors	receptor	NOUN
dti-1335	41	4	are	be	AUX
dti-1335	41	5	not	not	PART
dti-1335	41	6	thought	think	VERB
dti-1335	41	7	to	to	PART
dti-1335	41	8	be	be	AUX
dti-1335	41	9	involved	involve	VERB
dti-1335	41	10	in	in	ADP
dti-1335	41	11	cell	cell	NOUN
dti-1335	41	12	signaling	signal	VERB
dti-1335	41	13	.	.	PUNCT
dti-1335	42	1	there	there	PRON
dti-1335	42	2	is	be	VERB
dti-1335	42	3	ample	ample	ADJ
dti-1335	42	4	consensus	consensus	NOUN
dti-1335	42	5	today	today	NOUN
dti-1335	42	6	that	that	SCONJ
dti-1335	42	7	the	the	DET
dti-1335	42	8	biological	biological	ADJ
dti-1335	42	9	actions	action	NOUN
dti-1335	42	10	of	of	ADP
dti-1335	42	11	both	both	DET
dti-1335	42	12	igf-1	igf-1	NOUN
dti-1335	42	13	and	and	CCONJ
dti-1335	42	14	-2	-2	NOUN
dti-1335	42	15	are	be	AUX
dti-1335	42	16	mediated	mediate	VERB
dti-1335	42	17	through	through	ADP
dti-1335	42	18	type-1	type-1	PROPN
dti-1335	42	19	igf	igf	NOUN
dti-1335	42	20	receptors	receptor	NOUN
dti-1335	42	21	.	.	PUNCT
dti-1335	43	1	in	in	ADP
dti-1335	43	2	vitro	vitro	X
dti-1335	43	3	and	and	CCONJ
dti-1335	43	4	in	in	ADP
dti-1335	43	5	vivo	vivo	NOUN
dti-1335	43	6	,	,	PUNCT
dti-1335	43	7	igf-1	igf-1	NOUN
dti-1335	43	8	stimulates	stimulate	VERB
dti-1335	43	9	dna	dna	ADJ
dti-1335	43	10	synthesis	synthesis	NOUN
dti-1335	43	11	and	and	CCONJ
dti-1335	43	12	cell	cell	NOUN
dti-1335	43	13	growth	growth	NOUN
dti-1335	43	14	.	.	PUNCT
dti-1335	44	1	a	a	DET
dti-1335	44	2	cellular	cellular	ADJ
dti-1335	44	3	action	action	NOUN
dti-1335	44	4	of	of	ADP
dti-1335	44	5	igf1	igf1	PROPN
dti-1335	44	6	that	that	PRON
dti-1335	44	7	is	be	AUX
dti-1335	44	8	complementary	complementary	ADJ
dti-1335	44	9	to	to	ADP
dti-1335	44	10	its	its	PRON
dti-1335	44	11	stimulation	stimulation	NOUN
dti-1335	44	12	of	of	ADP
dti-1335	44	13	cell	cell	NOUN
dti-1335	44	14	proliferation	proliferation	NOUN
dti-1335	44	15	is	be	AUX
dti-1335	44	16	its	its	PRON
dti-1335	44	17	capacity	capacity	NOUN
dti-1335	44	18	in	in	ADP
dti-1335	44	19	certain	certain	ADJ
dti-1335	44	20	cells	cell	NOUN
dti-1335	44	21	to	to	PART
dti-1335	44	22	inhibit	inhibit	VERB
dti-1335	44	23	apoptosis	apoptosis	NOUN
dti-1335	44	24	.	.	PUNCT
dti-1335	45	1	igf-1	igf-1	NOUN
dti-1335	45	2	also	also	ADV
dti-1335	45	3	induces	induce	VERB
dti-1335	45	4	differentiation	differentiation	NOUN
dti-1335	45	5	of	of	ADP
dti-1335	45	6	neurons	neuron	NOUN
dti-1335	45	7	and	and	CCONJ
dti-1335	45	8	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	45	9	(	(	PUNCT
dti-1335	45	10	feldman	feldman	PROPN
dti-1335	45	11	et	et	PROPN
dti-1335	45	12	al	al	PROPN
dti-1335	45	13	.	.	PROPN
dti-1335	45	14	1997	1997	NUM
dti-1335	45	15	)	)	PUNCT
dti-1335	45	16	.	.	PUNCT
dti-1335	46	1	two	two	NUM
dti-1335	46	2	major	major	ADJ
dti-1335	46	3	pathways	pathway	NOUN
dti-1335	46	4	induce	induce	VERB
dti-1335	46	5	the	the	DET
dti-1335	46	6	actions	action	NOUN
dti-1335	46	7	of	of	ADP
dti-1335	46	8	igf-1	igf-1	NOUN
dti-1335	46	9	and	and	CCONJ
dti-1335	46	10	igf-2	igf-2	ADV
dti-1335	46	11	through	through	ADP
dti-1335	46	12	type-1	type-1	NUM
dti-1335	46	13	igf	igf	NOUN
dti-1335	46	14	receptors	receptor	NOUN
dti-1335	46	15	,	,	PUNCT
dti-1335	46	16	the	the	DET
dti-1335	46	17	fi	fi	NOUN
dti-1335	46	18	rst	rst	PROPN
dti-1335	46	19	is	be	AUX
dti-1335	46	20	the	the	DET
dti-1335	46	21	mitogen	mitogen	NOUN
dti-1335	46	22	-	-	PUNCT
dti-1335	46	23	activated	activate	VERB
dti-1335	46	24	protein	protein	NOUN
dti-1335	46	25	(	(	PUNCT
dti-1335	46	26	map	map	NOUN
dti-1335	46	27	)	)	PUNCT
dti-1335	46	28	kinase	kinase	NOUN
dti-1335	46	29	pathway	pathway	NOUN
dti-1335	46	30	and	and	CCONJ
dti-1335	46	31	the	the	DET
dti-1335	46	32	second	second	NOUN
dti-1335	46	33	is	be	AUX
dti-1335	46	34	the	the	DET
dti-1335	46	35	serine	serine	NOUN
dti-1335	46	36	-	-	PUNCT
dti-1335	46	37	threonine	threonine	ADJ
dti-1335	46	38	protein	protein	NOUN
dti-1335	46	39	kinase	kinase	PROPN
dti-1335	46	40	akt	akt	PROPN
dti-1335	46	41	pathway	pathway	NOUN
dti-1335	46	42	.	.	PUNCT
dti-1335	47	1	the	the	DET
dti-1335	47	2	map	map	NOUN
dti-1335	47	3	kinase	kinase	PROPN
dti-1335	47	4	pathway	pathway	NOUN
dti-1335	47	5	is	be	AUX
dti-1335	47	6	often	often	ADV
dti-1335	47	7	associated	associate	VERB
dti-1335	47	8	in	in	ADP
dti-1335	47	9	proliferation	proliferation	NOUN
dti-1335	47	10	and	and	CCONJ
dti-1335	47	11	differentiation	differentiation	NOUN
dti-1335	47	12	(	(	PUNCT
dti-1335	47	13	kim	kim	PROPN
dti-1335	47	14	et	et	PROPN
dti-1335	47	15	al	al	PROPN
dti-1335	47	16	.	.	PROPN
dti-1335	47	17	1997	1997	NUM
dti-1335	47	18	)	)	PUNCT
dti-1335	47	19	,	,	PUNCT
dti-1335	47	20	whereas	whereas	SCONJ
dti-1335	47	21	the	the	DET
dti-1335	47	22	akt	akt	PROPN
dti-1335	47	23	pathway	pathway	NOUN
dti-1335	47	24	is	be	AUX
dti-1335	47	25	induced	induce	VERB
dti-1335	47	26	in	in	ADP
dti-1335	47	27	igf-1	igf-1	NOUN
dti-1335	47	28	mediated	mediate	VERB
dti-1335	47	29	cell	cell	NOUN
dti-1335	47	30	survival	survival	NOUN
dti-1335	47	31	(	(	PUNCT
dti-1335	47	32	brunet	brunet	NOUN
dti-1335	47	33	et	et	PROPN
dti-1335	47	34	al	al	PROPN
dti-1335	47	35	.	.	PROPN
dti-1335	47	36	1999	1999	NUM
dti-1335	47	37	)	)	PUNCT
dti-1335	47	38	and	and	CCONJ
dti-1335	47	39	protection	protection	NOUN
dti-1335	47	40	from	from	ADP
dti-1335	47	41	apoptosis	apoptosis	NOUN
dti-1335	47	42	(	(	PUNCT
dti-1335	47	43	kermer	kermer	PROPN
dti-1335	47	44	et	et	PROPN
dti-1335	47	45	al	al	PROPN
dti-1335	47	46	.	.	PROPN
dti-1335	47	47	2000	2000	NUM
dti-1335	47	48	)	)	PUNCT
dti-1335	47	49	.	.	PUNCT
dti-1335	48	1	biological	biological	ADJ
dti-1335	48	2	actions	action	NOUN
dti-1335	48	3	of	of	ADP
dti-1335	48	4	igf-1	igf-1	ADJ
dti-1335	48	5	and	and	CCONJ
dti-1335	48	6	igf-2	igf-2	ADV
dti-1335	48	7	are	be	AUX
dti-1335	48	8	modulated	modulate	VERB
dti-1335	48	9	through	through	ADP
dti-1335	48	10	six	six	NUM
dti-1335	48	11	igfbps	igfbps	NOUN
dti-1335	48	12	.	.	PUNCT
dti-1335	49	1	these	these	DET
dti-1335	49	2	proteins	protein	NOUN
dti-1335	49	3	contain	contain	VERB
dti-1335	49	4	high	high	ADJ
dti-1335	49	5	affi	affi	PROPN
dti-1335	49	6	nity	nity	NOUN
dti-1335	49	7	binding	bind	VERB
dti-1335	49	8	sites	site	NOUN
dti-1335	49	9	for	for	ADP
dti-1335	49	10	igf-1	igf-1	NOUN
dti-1335	49	11	and	and	CCONJ
dti-1335	49	12	igf-2	igf-2	NOUN
dti-1335	49	13	,	,	PUNCT
dti-1335	49	14	and	and	CCONJ
dti-1335	49	15	they	they	PRON
dti-1335	49	16	possess	possess	VERB
dti-1335	49	17	an	an	DET
dti-1335	49	18	80	80	NUM
dti-1335	49	19	%	%	NOUN
dti-1335	49	20	sequence	sequence	NOUN
dti-1335	49	21	homology	homology	NOUN
dti-1335	49	22	with	with	ADP
dti-1335	49	23	each	each	DET
dti-1335	49	24	other	other	ADJ
dti-1335	49	25	(	(	PUNCT
dti-1335	49	26	rajaram	rajaram	PROPN
dti-1335	49	27	et	et	PROPN
dti-1335	49	28	al	al	PROPN
dti-1335	49	29	.	.	PROPN
dti-1335	49	30	1997	1997	NUM
dti-1335	49	31	)	)	PUNCT
dti-1335	49	32	.	.	PUNCT
dti-1335	50	1	in	in	ADP
dti-1335	50	2	the	the	DET
dti-1335	50	3	circulation	circulation	NOUN
dti-1335	50	4	,	,	PUNCT
dti-1335	50	5	the	the	DET
dti-1335	50	6	major	major	ADJ
dti-1335	50	7	igfbp	igfbp	ADJ
dti-1335	50	8	form	form	NOUN
dti-1335	50	9	is	be	AUX
dti-1335	50	10	igfbp-3	igfbp-3	NUM
dti-1335	50	11	,	,	PUNCT
dti-1335	50	12	which	which	PRON
dti-1335	50	13	binds	bind	VERB
dti-1335	50	14	igf-1	igf-1	PRON
dti-1335	50	15	and	and	CCONJ
dti-1335	50	16	igf-2	igf-2	ADV
dti-1335	50	17	with	with	ADP
dti-1335	50	18	similar	similar	ADJ
dti-1335	50	19	affi	affi	PROPN
dti-1335	50	20	nities	nitie	NOUN
dti-1335	50	21	(	(	PUNCT
dti-1335	50	22	baxter	baxter	PROPN
dti-1335	50	23	,	,	PUNCT
dti-1335	50	24	1994	1994	NUM
dti-1335	50	25	)	)	PUNCT
dti-1335	50	26	.	.	PUNCT
dti-1335	51	1	circulating	circulate	VERB
dti-1335	51	2	igfbp-3	igfbp-3	PRON
dti-1335	51	3	inhibits	inhibit	VERB
dti-1335	51	4	insulin	insulin	NOUN
dti-1335	51	5	-	-	PUNCT
dti-1335	51	6	like	like	ADJ
dti-1335	51	7	activity	activity	NOUN
dti-1335	51	8	,	,	PUNCT
dti-1335	51	9	regulates	regulate	VERB
dti-1335	51	10	the	the	DET
dti-1335	51	11	rate	rate	NOUN
dti-1335	51	12	of	of	ADP
dti-1335	51	13	transport	transport	NOUN
dti-1335	51	14	figure	figure	NOUN
dti-1335	51	15	1	1	NUM
dti-1335	51	16	.	.	PUNCT
dti-1335	51	17	luxol	luxol	NOUN
dti-1335	51	18	-	-	PUNCT
dti-1335	51	19	fast	fast	ADV
dti-1335	51	20	blue	blue	ADJ
dti-1335	51	21	staining	stain	VERB
dti-1335	51	22	(	(	PUNCT
dti-1335	51	23	myelin	myelin	NOUN
dti-1335	51	24	staining	staining	NOUN
dti-1335	51	25	)	)	PUNCT
dti-1335	51	26	of	of	ADP
dti-1335	51	27	the	the	DET
dti-1335	51	28	white	white	ADJ
dti-1335	51	29	matter	matter	NOUN
dti-1335	51	30	from	from	ADP
dti-1335	51	31	ms	ms	PROPN
dti-1335	51	32	(	(	PUNCT
dti-1335	51	33	a	a	PROPN
dti-1335	51	34	)	)	PUNCT
dti-1335	51	35	.	.	PUNCT
dti-1335	52	1	the	the	DET
dti-1335	52	2	pale	pale	ADJ
dti-1335	52	3	area	area	NOUN
dti-1335	52	4	is	be	AUX
dti-1335	52	5	a	a	DET
dti-1335	52	6	demyelinated	demyelinated	ADJ
dti-1335	52	7	plaque	plaque	NOUN
dti-1335	52	8	(	(	PUNCT
dti-1335	52	9	black	black	ADJ
dti-1335	52	10	arrows	arrow	NOUN
dti-1335	52	11	)	)	PUNCT
dti-1335	52	12	and	and	CCONJ
dti-1335	52	13	the	the	DET
dti-1335	52	14	surrounding	surround	VERB
dti-1335	52	15	non	non	ADJ
dti-1335	52	16	-	-	ADJ
dti-1335	52	17	affected	affected	ADJ
dti-1335	52	18	area	area	NOUN
dti-1335	52	19	is	be	AUX
dti-1335	52	20	myelinated	myelinate	VERB
dti-1335	52	21	white	white	ADJ
dti-1335	52	22	matter	matter	NOUN
dti-1335	52	23	(	(	PUNCT
dti-1335	52	24	white	white	ADJ
dti-1335	52	25	arrows	arrow	NOUN
dti-1335	52	26	)	)	PUNCT
dti-1335	52	27	.	.	PUNCT
dti-1335	53	1	gfap	gfap	ADJ
dti-1335	53	2	-	-	PUNCT
dti-1335	53	3	staining	staining	NOUN
dti-1335	53	4	of	of	ADP
dti-1335	53	5	astrocytes	astrocyte	NOUN
dti-1335	53	6	in	in	ADP
dti-1335	53	7	a	a	DET
dti-1335	53	8	ms	ms	NOUN
dti-1335	53	9	plaque	plaque	NOUN
dti-1335	53	10	(	(	PUNCT
dti-1335	53	11	b	b	NOUN
dti-1335	53	12	)	)	PUNCT
dti-1335	53	13	showing	show	VERB
dti-1335	53	14	the	the	DET
dti-1335	53	15	presence	presence	NOUN
dti-1335	53	16	of	of	ADP
dti-1335	53	17	large	large	ADJ
dti-1335	53	18	reactive	reactive	ADJ
dti-1335	53	19	astrocytes	astrocyte	NOUN
dti-1335	53	20	in	in	ADP
dti-1335	53	21	ms	ms	PROPN
dti-1335	53	22	(	(	PUNCT
dti-1335	53	23	black	black	ADJ
dti-1335	53	24	arrows	arrow	NOUN
dti-1335	53	25	)	)	PUNCT
dti-1335	53	26	and	and	CCONJ
dti-1335	53	27	normal	normal	ADJ
dti-1335	53	28	astrocytes	astrocyte	NOUN
dti-1335	53	29	surrounding	surround	VERB
dti-1335	53	30	the	the	DET
dti-1335	53	31	ms	ms	NOUN
dti-1335	53	32	plaque	plaque	NOUN
dti-1335	53	33	(	(	PUNCT
dti-1335	53	34	white	white	ADJ
dti-1335	53	35	arrows	arrow	NOUN
dti-1335	53	36	)	)	PUNCT
dti-1335	53	37	.	.	PUNCT
dti-1335	54	1	astrocytes	astrocyte	NOUN
dti-1335	54	2	in	in	ADP
dti-1335	54	3	the	the	DET
dti-1335	54	4	ms	ms	PROPN
dti-1335	54	5	plaques	plaque	NOUN
dti-1335	54	6	are	be	AUX
dti-1335	54	7	stained	stain	VERB
dti-1335	54	8	using	use	VERB
dti-1335	54	9	an	an	DET
dti-1335	54	10	antibody	antibody	NOUN
dti-1335	54	11	against	against	ADP
dti-1335	54	12	glial	glial	ADJ
dti-1335	54	13	fi	fi	NOUN
dti-1335	54	14	brillary	brillary	ADJ
dti-1335	54	15	acidic	acidic	ADJ
dti-1335	54	16	protein	protein	NOUN
dti-1335	54	17	(	(	PUNCT
dti-1335	54	18	gfap	gfap	ADJ
dti-1335	54	19	)	)	PUNCT
dti-1335	54	20	a	a	DET
dti-1335	54	21	specifi	specifi	PROPN
dti-1335	54	22	c	c	PROPN
dti-1335	54	23	marker	marker	NOUN
dti-1335	54	24	for	for	ADP
dti-1335	54	25	astrocytes	astrocyte	NOUN
dti-1335	54	26	.	.	PUNCT
dti-1335	55	1	39	39	NUM
dti-1335	55	2	targeting	target	VERB
dti-1335	55	3	insulin	insulin	NOUN
dti-1335	55	4	-	-	PUNCT
dti-1335	55	5	like	like	ADJ
dti-1335	55	6	growth	growth	NOUN
dti-1335	55	7	factor-1	factor-1	NUM
dti-1335	55	8	drug	drug	NOUN
dti-1335	55	9	target	target	NOUN
dti-1335	55	10	insights	insight	NOUN
dti-1335	55	11	2008:3	2008:3	NUM
dti-1335	55	12	and	and	CCONJ
dti-1335	55	13	prolongs	prolong	VERB
dti-1335	55	14	half	half	ADJ
dti-1335	55	15	-	-	PUNCT
dti-1335	55	16	lives	life	NOUN
dti-1335	55	17	of	of	ADP
dti-1335	55	18	plasma	plasma	NOUN
dti-1335	55	19	igf-1	igf-1	NOUN
dti-1335	55	20	and	and	CCONJ
dti-1335	55	21	igf-2	igf-2	NOUN
dti-1335	55	22	.	.	PUNCT
dti-1335	56	1	as	as	ADP
dti-1335	56	2	carrier	carrier	NOUN
dti-1335	56	3	proteins	protein	NOUN
dti-1335	56	4	of	of	ADP
dti-1335	56	5	igf-1	igf-1	NOUN
dti-1335	56	6	and	and	CCONJ
dti-1335	56	7	igf-2	igf-2	NOUN
dti-1335	56	8	,	,	PUNCT
dti-1335	56	9	a	a	DET
dti-1335	56	10	major	major	ADJ
dti-1335	56	11	function	function	NOUN
dti-1335	56	12	of	of	ADP
dti-1335	56	13	igfbps	igfbps	NOUN
dti-1335	56	14	is	be	AUX
dti-1335	56	15	to	to	PART
dti-1335	56	16	transport	transport	VERB
dti-1335	56	17	and	and	CCONJ
dti-1335	56	18	target	target	VERB
dti-1335	56	19	igfs	igf	NOUN
dti-1335	56	20	to	to	PART
dti-1335	56	21	specifi	specifi	PROPN
dti-1335	56	22	c	c	PROPN
dti-1335	56	23	tissues	tissue	NOUN
dti-1335	56	24	and	and	CCONJ
dti-1335	56	25	cell	cell	NOUN
dti-1335	56	26	types	type	NOUN
dti-1335	56	27	.	.	PUNCT
dti-1335	57	1	therefore	therefore	ADV
dti-1335	57	2	,	,	PUNCT
dti-1335	57	3	these	these	DET
dti-1335	57	4	proteins	protein	NOUN
dti-1335	57	5	have	have	VERB
dti-1335	57	6	a	a	DET
dti-1335	57	7	central	central	ADJ
dti-1335	57	8	position	position	NOUN
dti-1335	57	9	in	in	ADP
dti-1335	57	10	igf	igf	PROPN
dti-1335	57	11	ligand	ligand	NOUN
dti-1335	57	12	-	-	PUNCT
dti-1335	57	13	receptor	receptor	NOUN
dti-1335	57	14	interactions	interaction	NOUN
dti-1335	57	15	by	by	ADP
dti-1335	57	16	infl	infl	PROPN
dti-1335	57	17	uencing	uence	VERB
dti-1335	57	18	bioavailability	bioavailability	NOUN
dti-1335	57	19	and	and	CCONJ
dti-1335	57	20	extracellular	extracellular	ADJ
dti-1335	57	21	distribution	distribution	NOUN
dti-1335	57	22	.	.	PUNCT
dti-1335	58	1	igfbps	igfbps	NOUN
dti-1335	58	2	are	be	AUX
dti-1335	58	3	able	able	ADJ
dti-1335	58	4	to	to	PART
dti-1335	58	5	enhance	enhance	VERB
dti-1335	58	6	or	or	CCONJ
dti-1335	58	7	inhibit	inhibit	VERB
dti-1335	58	8	igf	igf	PROPN
dti-1335	58	9	effects	effect	NOUN
dti-1335	58	10	by	by	ADP
dti-1335	58	11	regulating	regulate	VERB
dti-1335	58	12	binding	bind	VERB
dti-1335	58	13	to	to	ADP
dti-1335	58	14	type-1	type-1	PROPN
dti-1335	58	15	igf	igf	NOUN
dti-1335	58	16	receptors	receptor	NOUN
dti-1335	58	17	,	,	PUNCT
dti-1335	58	18	a	a	DET
dti-1335	58	19	mechanism	mechanism	NOUN
dti-1335	58	20	that	that	PRON
dti-1335	58	21	is	be	AUX
dti-1335	58	22	thought	think	VERB
dti-1335	58	23	to	to	PART
dti-1335	58	24	be	be	AUX
dti-1335	58	25	dependent	dependent	ADJ
dti-1335	58	26	on	on	ADP
dti-1335	58	27	specifi	specifi	PROPN
dti-1335	58	28	c	c	PROPN
dti-1335	58	29	cell	cell	NOUN
dti-1335	58	30	and	and	CCONJ
dti-1335	58	31	tissue	tissue	NOUN
dti-1335	58	32	properties	property	NOUN
dti-1335	58	33	(	(	PUNCT
dti-1335	58	34	firth	firth	PROPN
dti-1335	58	35	and	and	CCONJ
dti-1335	58	36	baxter	baxter	PROPN
dti-1335	58	37	,	,	PUNCT
dti-1335	58	38	2002	2002	NUM
dti-1335	58	39	)	)	PUNCT
dti-1335	58	40	.	.	PUNCT
dti-1335	59	1	binding	bind	VERB
dti-1335	59	2	of	of	ADP
dti-1335	59	3	igf	igf	PROPN
dti-1335	59	4	/	/	SYM
dti-1335	59	5	igfbp	igfbp	ADJ
dti-1335	59	6	complexes	complex	NOUN
dti-1335	59	7	to	to	ADP
dti-1335	59	8	components	component	NOUN
dti-1335	59	9	of	of	ADP
dti-1335	59	10	the	the	DET
dti-1335	59	11	extracellular	extracellular	ADJ
dti-1335	59	12	matrix	matrix	NOUN
dti-1335	59	13	(	(	PUNCT
dti-1335	59	14	ecm	ecm	PROPN
dti-1335	59	15	)	)	PUNCT
dti-1335	59	16	and	and	CCONJ
dti-1335	59	17	the	the	DET
dti-1335	59	18	cell	cell	NOUN
dti-1335	59	19	-	-	PUNCT
dti-1335	59	20	surface	surface	NOUN
dti-1335	59	21	can	can	AUX
dti-1335	59	22	facilitate	facilitate	VERB
dti-1335	59	23	the	the	DET
dti-1335	59	24	release	release	NOUN
dti-1335	59	25	of	of	ADP
dti-1335	59	26	igfs	igfs	NOUN
dti-1335	59	27	leading	lead	VERB
dti-1335	59	28	to	to	ADP
dti-1335	59	29	enhanced	enhanced	ADJ
dti-1335	59	30	delivery	delivery	NOUN
dti-1335	59	31	to	to	ADP
dti-1335	59	32	type-1	type-1	PROPN
dti-1335	59	33	and	and	CCONJ
dti-1335	59	34	type-2	type-2	NUM
dti-1335	59	35	igf	igf	NOUN
dti-1335	59	36	receptors	receptor	NOUN
dti-1335	59	37	.	.	PUNCT
dti-1335	60	1	for	for	ADP
dti-1335	60	2	example	example	NOUN
dti-1335	60	3	,	,	PUNCT
dti-1335	60	4	the	the	DET
dti-1335	60	5	binding	binding	NOUN
dti-1335	60	6	of	of	ADP
dti-1335	60	7	igfbp-2	igfbp-2	PROPN
dti-1335	60	8	to	to	ADP
dti-1335	60	9	chondroitin6	chondroitin6	NOUN
dti-1335	60	10	-	-	PUNCT
dti-1335	60	11	sulphate	sulphate	NOUN
dti-1335	60	12	,	,	PUNCT
dti-1335	60	13	an	an	DET
dti-1335	60	14	ecm	ecm	PROPN
dti-1335	60	15	component	component	NOUN
dti-1335	60	16	,	,	PUNCT
dti-1335	60	17	decreases	decrease	VERB
dti-1335	60	18	the	the	DET
dti-1335	60	19	binding	bind	VERB
dti-1335	60	20	affi	affi	ADJ
dti-1335	60	21	nity	nity	NOUN
dti-1335	60	22	of	of	ADP
dti-1335	60	23	igfbp-2	igfbp-2	PROPN
dti-1335	60	24	to	to	PART
dti-1335	60	25	igf-1	igf-1	VERB
dti-1335	60	26	by	by	ADP
dti-1335	60	27	3	3	NUM
dti-1335	60	28	-	-	NOUN
dti-1335	60	29	fold	fold	ADJ
dti-1335	60	30	in	in	ADP
dti-1335	60	31	rat	rat	NOUN
dti-1335	60	32	brain	brain	NOUN
dti-1335	60	33	,	,	PUNCT
dti-1335	60	34	leading	lead	VERB
dti-1335	60	35	to	to	ADP
dti-1335	60	36	increased	increase	VERB
dti-1335	60	37	levels	level	NOUN
dti-1335	60	38	of	of	ADP
dti-1335	60	39	biologically	biologically	ADV
dti-1335	60	40	active	active	ADJ
dti-1335	60	41	igf-1	igf-1	NOUN
dti-1335	60	42	(	(	PUNCT
dti-1335	60	43	russo	russo	PROPN
dti-1335	60	44	et	et	PROPN
dti-1335	60	45	al	al	PROPN
dti-1335	60	46	.	.	PROPN
dti-1335	60	47	1997	1997	NUM
dti-1335	60	48	)	)	PUNCT
dti-1335	60	49	.	.	PUNCT
dti-1335	61	1	another	another	DET
dti-1335	61	2	mechanism	mechanism	NOUN
dti-1335	61	3	involved	involve	VERB
dti-1335	61	4	in	in	ADP
dti-1335	61	5	igf	igf	PROPN
dti-1335	61	6	regulation	regulation	NOUN
dti-1335	61	7	are	be	AUX
dti-1335	61	8	specifi	specifi	PROPN
dti-1335	61	9	c	c	NOUN
dti-1335	61	10	proteases	protease	NOUN
dti-1335	61	11	,	,	PUNCT
dti-1335	61	12	which	which	PRON
dti-1335	61	13	are	be	AUX
dti-1335	61	14	secreted	secrete	VERB
dti-1335	61	15	by	by	ADP
dti-1335	61	16	cells	cell	NOUN
dti-1335	61	17	and	and	CCONJ
dti-1335	61	18	act	act	VERB
dti-1335	61	19	as	as	ADP
dti-1335	61	20	growth	growth	NOUN
dti-1335	61	21	stimulators	stimulator	NOUN
dti-1335	61	22	by	by	ADP
dti-1335	61	23	increasing	increase	VERB
dti-1335	61	24	local	local	ADJ
dti-1335	61	25	igf	igf	NOUN
dti-1335	61	26	availability	availability	NOUN
dti-1335	61	27	(	(	PUNCT
dti-1335	61	28	conover	conover	PROPN
dti-1335	61	29	et	et	PROPN
dti-1335	61	30	al	al	PROPN
dti-1335	61	31	.	.	PROPN
dti-1335	61	32	1993	1993	NUM
dti-1335	61	33	)	)	PUNCT
dti-1335	61	34	.	.	PUNCT
dti-1335	62	1	circulating	circulate	VERB
dti-1335	62	2	and	and	CCONJ
dti-1335	62	3	tissue	tissue	NOUN
dti-1335	62	4	specifi	specifi	X
dti-1335	62	5	c	c	PROPN
dti-1335	62	6	igfbps	igfbps	NOUN
dti-1335	62	7	bind	bind	VERB
dti-1335	62	8	igf-1	igf-1	ADV
dti-1335	62	9	and	and	CCONJ
dti-1335	62	10	igf-2	igf-2	ADV
dti-1335	62	11	by	by	ADP
dti-1335	62	12	forming	form	VERB
dti-1335	62	13	biologically	biologically	ADV
dti-1335	62	14	inactive	inactive	ADJ
dti-1335	62	15	igf	igf	PROPN
dti-1335	62	16	/	/	SYM
dti-1335	62	17	igfbp	igfbp	ADJ
dti-1335	62	18	complexes	complex	NOUN
dti-1335	62	19	.	.	PUNCT
dti-1335	63	1	igf-1	igf-1	NOUN
dti-1335	63	2	and	and	CCONJ
dti-1335	63	3	-2	-2	NOUN
dti-1335	63	4	can	can	AUX
dti-1335	63	5	be	be	AUX
dti-1335	63	6	released	release	VERB
dti-1335	63	7	from	from	ADP
dti-1335	63	8	these	these	DET
dti-1335	63	9	complexes	complex	NOUN
dti-1335	63	10	,	,	PUNCT
dti-1335	63	11	for	for	ADP
dti-1335	63	12	example	example	NOUN
dti-1335	63	13	by	by	ADP
dti-1335	63	14	proteolysis	proteolysis	NOUN
dti-1335	63	15	of	of	ADP
dti-1335	63	16	igfbps	igfbps	NOUN
dti-1335	63	17	.	.	PUNCT
dti-1335	64	1	igfbp	igfbp	PROPN
dti-1335	64	2	fragments	fragment	NOUN
dti-1335	64	3	generated	generate	VERB
dti-1335	64	4	by	by	ADP
dti-1335	64	5	the	the	DET
dti-1335	64	6	action	action	NOUN
dti-1335	64	7	of	of	ADP
dti-1335	64	8	cellular	cellular	ADJ
dti-1335	64	9	proteases	protease	NOUN
dti-1335	64	10	show	show	VERB
dti-1335	64	11	a	a	DET
dti-1335	64	12	marked	mark	VERB
dti-1335	64	13	loss	loss	NOUN
dti-1335	64	14	of	of	ADP
dti-1335	64	15	igf	igf	PROPN
dti-1335	64	16	binding	bind	VERB
dti-1335	64	17	affi	affi	PROPN
dti-1335	64	18	nity	nity	NOUN
dti-1335	64	19	.	.	PUNCT
dti-1335	65	1	in	in	ADP
dti-1335	65	2	conclusion	conclusion	NOUN
dti-1335	65	3	,	,	PUNCT
dti-1335	65	4	igfbps	igfbps	NOUN
dti-1335	65	5	can	can	AUX
dti-1335	65	6	influence	influence	VERB
dti-1335	65	7	igf	igf	PROPN
dti-1335	65	8	actions	action	NOUN
dti-1335	65	9	in	in	ADP
dti-1335	65	10	different	different	ADJ
dti-1335	65	11	ways	way	NOUN
dti-1335	65	12	.	.	PUNCT
dti-1335	66	1	the	the	DET
dti-1335	66	2	multitude	multitude	NOUN
dti-1335	66	3	of	of	ADP
dti-1335	66	4	these	these	DET
dti-1335	66	5	effects	effect	NOUN
dti-1335	66	6	depends	depend	VERB
dti-1335	66	7	on	on	ADP
dti-1335	66	8	the	the	DET
dti-1335	66	9	cell	cell	NOUN
dti-1335	66	10	type	type	NOUN
dti-1335	66	11	in	in	ADP
dti-1335	66	12	which	which	PRON
dti-1335	66	13	they	they	PRON
dti-1335	66	14	are	be	AUX
dti-1335	66	15	expressed	express	VERB
dti-1335	66	16	,	,	PUNCT
dti-1335	66	17	how	how	SCONJ
dti-1335	66	18	they	they	PRON
dti-1335	66	19	interact	interact	VERB
dti-1335	66	20	with	with	ADP
dti-1335	66	21	cell	cell	NOUN
dti-1335	66	22	surfaces	surface	NOUN
dti-1335	66	23	and	and	CCONJ
dti-1335	66	24	ecm	ecm	NOUN
dti-1335	66	25	,	,	PUNCT
dti-1335	66	26	the	the	DET
dti-1335	66	27	presence	presence	NOUN
dti-1335	66	28	of	of	ADP
dti-1335	66	29	specifi	specifi	PROPN
dti-1335	66	30	c	c	PROPN
dti-1335	66	31	proteases	protease	NOUN
dti-1335	66	32	and	and	CCONJ
dti-1335	66	33	the	the	DET
dti-1335	66	34	formation	formation	NOUN
dti-1335	66	35	of	of	ADP
dti-1335	66	36	high	high	ADJ
dti-1335	66	37	affi	affi	PROPN
dti-1335	66	38	nity	nity	NOUN
dti-1335	66	39	binding	bind	VERB
dti-1335	66	40	proteins	protein	NOUN
dti-1335	66	41	complexed	complexe	VERB
dti-1335	66	42	with	with	ADP
dti-1335	66	43	igfs	igfs	NOUN
dti-1335	66	44	.	.	PUNCT
dti-1335	67	1	the	the	DET
dti-1335	67	2	role	role	NOUN
dti-1335	67	3	of	of	ADP
dti-1335	67	4	insulin	insulin	NOUN
dti-1335	67	5	-	-	PUNCT
dti-1335	67	6	like	like	ADJ
dti-1335	67	7	growth	growth	NOUN
dti-1335	67	8	factor-1	factor-1	NUM
dti-1335	67	9	in	in	ADP
dti-1335	67	10	multiple	multiple	ADJ
dti-1335	67	11	sclerosis	sclerosis	NOUN
dti-1335	67	12	during	during	ADP
dti-1335	67	13	nervous	nervous	ADJ
dti-1335	67	14	system	system	NOUN
dti-1335	67	15	development	development	NOUN
dti-1335	67	16	,	,	PUNCT
dti-1335	67	17	igf-1	igf-1	NOUN
dti-1335	67	18	plays	play	VERB
dti-1335	67	19	a	a	DET
dti-1335	67	20	crucial	crucial	ADJ
dti-1335	67	21	role	role	NOUN
dti-1335	67	22	in	in	ADP
dti-1335	67	23	cell	cell	NOUN
dti-1335	67	24	proliferation	proliferation	NOUN
dti-1335	67	25	,	,	PUNCT
dti-1335	67	26	differentiation	differentiation	NOUN
dti-1335	67	27	,	,	PUNCT
dti-1335	67	28	and	and	CCONJ
dti-1335	67	29	survival	survival	NOUN
dti-1335	67	30	(	(	PUNCT
dti-1335	67	31	bondy	bondy	PROPN
dti-1335	67	32	and	and	CCONJ
dti-1335	67	33	cheng	cheng	PROPN
dti-1335	67	34	,	,	PUNCT
dti-1335	67	35	2004	2004	NUM
dti-1335	67	36	;	;	PUNCT
dti-1335	67	37	russo	russo	PROPN
dti-1335	67	38	et	et	PROPN
dti-1335	67	39	al	al	PROPN
dti-1335	67	40	.	.	PROPN
dti-1335	67	41	2005	2005	NUM
dti-1335	67	42	)	)	PUNCT
dti-1335	67	43	.	.	PUNCT
dti-1335	68	1	during	during	ADP
dti-1335	68	2	that	that	DET
dti-1335	68	3	period	period	NOUN
dti-1335	68	4	igf-1	igf-1	NOUN
dti-1335	68	5	and	and	CCONJ
dti-1335	68	6	type-1	type-1	NUM
dti-1335	68	7	igf	igf	NOUN
dti-1335	68	8	receptors	receptor	NOUN
dti-1335	68	9	are	be	AUX
dti-1335	68	10	highly	highly	ADV
dti-1335	68	11	expressed	express	VERB
dti-1335	68	12	in	in	ADP
dti-1335	68	13	neuronal	neuronal	ADJ
dti-1335	68	14	rich	rich	ADJ
dti-1335	68	15	regions	region	NOUN
dti-1335	68	16	,	,	PUNCT
dti-1335	68	17	such	such	ADJ
dti-1335	68	18	as	as	ADP
dti-1335	68	19	the	the	DET
dti-1335	68	20	spinal	spinal	NOUN
dti-1335	68	21	cord	cord	NOUN
dti-1335	68	22	,	,	PUNCT
dti-1335	68	23	midbrain	midbrain	NOUN
dti-1335	68	24	,	,	PUNCT
dti-1335	68	25	cerebral	cerebral	ADJ
dti-1335	68	26	cortex	cortex	NOUN
dti-1335	68	27	,	,	PUNCT
dti-1335	68	28	hippocampus	hippocampus	NOUN
dti-1335	68	29	,	,	PUNCT
dti-1335	68	30	and	and	CCONJ
dti-1335	68	31	olfactory	olfactory	ADJ
dti-1335	68	32	bulb	bulb	NOUN
dti-1335	68	33	(	(	PUNCT
dti-1335	68	34	anlar	anlar	PROPN
dti-1335	68	35	et	et	PROPN
dti-1335	68	36	al	al	PROPN
dti-1335	68	37	.	.	PROPN
dti-1335	68	38	1999	1999	NUM
dti-1335	68	39	;	;	PUNCT
dti-1335	68	40	beck	beck	PROPN
dti-1335	68	41	et	et	PROPN
dti-1335	68	42	al	al	PROPN
dti-1335	68	43	.	.	PROPN
dti-1335	68	44	1988	1988	NUM
dti-1335	68	45	)	)	PUNCT
dti-1335	68	46	.	.	PUNCT
dti-1335	69	1	we	we	PRON
dti-1335	69	2	have	have	AUX
dti-1335	69	3	shown	show	VERB
dti-1335	69	4	that	that	SCONJ
dti-1335	69	5	cerebral	cerebral	ADJ
dti-1335	69	6	white	white	ADJ
dti-1335	69	7	matter	matter	NOUN
dti-1335	69	8	in	in	ADP
dti-1335	69	9	human	human	ADJ
dti-1335	69	10	neonates	neonate	NOUN
dti-1335	69	11	,	,	PUNCT
dti-1335	69	12	undergoing	undergo	VERB
dti-1335	69	13	active	active	ADJ
dti-1335	69	14	myelination	myelination	NOUN
dti-1335	69	15	,	,	PUNCT
dti-1335	69	16	contains	contain	VERB
dti-1335	69	17	a	a	DET
dti-1335	69	18	3	3	NUM
dti-1335	69	19	-	-	ADJ
dti-1335	69	20	fold	fold	ADJ
dti-1335	69	21	higher	high	ADJ
dti-1335	69	22	density	density	NOUN
dti-1335	69	23	of	of	ADP
dti-1335	69	24	type-1	type-1	PROPN
dti-1335	69	25	igf	igf	NOUN
dti-1335	69	26	receptors	receptor	NOUN
dti-1335	69	27	than	than	ADP
dti-1335	69	28	in	in	ADP
dti-1335	69	29	adults	adult	NOUN
dti-1335	69	30	,	,	PUNCT
dti-1335	69	31	indicating	indicate	VERB
dti-1335	69	32	that	that	SCONJ
dti-1335	69	33	igf-1	igf-1	NOUN
dti-1335	69	34	also	also	ADV
dti-1335	69	35	plays	play	VERB
dti-1335	69	36	a	a	DET
dti-1335	69	37	important	important	ADJ
dti-1335	69	38	role	role	NOUN
dti-1335	69	39	in	in	ADP
dti-1335	69	40	the	the	DET
dti-1335	69	41	myelination	myelination	NOUN
dti-1335	69	42	of	of	ADP
dti-1335	69	43	the	the	DET
dti-1335	69	44	human	human	ADJ
dti-1335	69	45	cns	cns	NOUN
dti-1335	69	46	(	(	PUNCT
dti-1335	69	47	de	de	PROPN
dti-1335	69	48	keyser	keyser	PROPN
dti-1335	69	49	et	et	PROPN
dti-1335	69	50	al	al	PROPN
dti-1335	69	51	.	.	PROPN
dti-1335	69	52	1994b	1994b	NUM
dti-1335	69	53	)	)	PUNCT
dti-1335	69	54	.	.	PUNCT
dti-1335	70	1	in	in	ADP
dti-1335	70	2	vitro	vitro	ADJ
dti-1335	70	3	experiments	experiment	NOUN
dti-1335	70	4	have	have	AUX
dti-1335	70	5	demonstrated	demonstrate	VERB
dti-1335	70	6	that	that	SCONJ
dti-1335	70	7	igf-1	igf-1	NOUN
dti-1335	70	8	greatly	greatly	ADV
dti-1335	70	9	enhances	enhance	VERB
dti-1335	70	10	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	70	11	survival	survival	NOUN
dti-1335	70	12	(	(	PUNCT
dti-1335	70	13	mcmorris	mcmorris	PROPN
dti-1335	70	14	et	et	PROPN
dti-1335	70	15	al	al	PROPN
dti-1335	70	16	.	.	PROPN
dti-1335	70	17	1986	1986	NUM
dti-1335	70	18	)	)	PUNCT
dti-1335	70	19	,	,	PUNCT
dti-1335	70	20	myelin	myelin	NOUN
dti-1335	70	21	production	production	NOUN
dti-1335	70	22	(	(	PUNCT
dti-1335	70	23	roth	roth	PROPN
dti-1335	70	24	et	et	PROPN
dti-1335	70	25	al	al	PROPN
dti-1335	70	26	.	.	PROPN
dti-1335	70	27	1995	1995	NUM
dti-1335	70	28	)	)	PUNCT
dti-1335	70	29	and	and	CCONJ
dti-1335	70	30	proliferation	proliferation	NOUN
dti-1335	70	31	of	of	ADP
dti-1335	70	32	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	70	33	precursors	precursor	NOUN
dti-1335	70	34	(	(	PUNCT
dti-1335	70	35	mozell	mozell	NOUN
dti-1335	70	36	and	and	CCONJ
dti-1335	70	37	mcmorris	mcmorris	PROPN
dti-1335	70	38	,	,	PUNCT
dti-1335	70	39	1991	1991	NUM
dti-1335	70	40	)	)	PUNCT
dti-1335	70	41	.	.	PUNCT
dti-1335	71	1	the	the	DET
dti-1335	71	2	effects	effect	NOUN
dti-1335	71	3	of	of	ADP
dti-1335	71	4	igf-1	igf-1	NOUN
dti-1335	71	5	are	be	AUX
dti-1335	71	6	not	not	PART
dti-1335	71	7	only	only	ADV
dti-1335	71	8	restricted	restrict	VERB
dti-1335	71	9	to	to	ADP
dti-1335	71	10	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	71	11	of	of	ADP
dti-1335	71	12	the	the	DET
dti-1335	71	13	cns	cns	NOUN
dti-1335	71	14	,	,	PUNCT
dti-1335	71	15	but	but	CCONJ
dti-1335	71	16	also	also	ADV
dti-1335	71	17	apply	apply	VERB
dti-1335	71	18	to	to	ADP
dti-1335	71	19	schwann	schwann	PROPN
dti-1335	71	20	cells	cell	NOUN
dti-1335	71	21	of	of	ADP
dti-1335	71	22	the	the	DET
dti-1335	71	23	pheripheral	pheripheral	ADJ
dti-1335	71	24	nervous	nervous	ADJ
dti-1335	71	25	system	system	NOUN
dti-1335	71	26	,	,	PUNCT
dti-1335	71	27	which	which	PRON
dti-1335	71	28	demonstrate	demonstrate	VERB
dti-1335	71	29	enhanced	enhanced	ADJ
dti-1335	71	30	differentiation	differentiation	NOUN
dti-1335	71	31	,	,	PUNCT
dti-1335	71	32	myelin	myelin	NOUN
dti-1335	71	33	production	production	NOUN
dti-1335	71	34	,	,	PUNCT
dti-1335	71	35	and	and	CCONJ
dti-1335	71	36	increased	increase	VERB
dti-1335	71	37	survival	survival	NOUN
dti-1335	71	38	in	in	ADP
dti-1335	71	39	response	response	NOUN
dti-1335	71	40	to	to	ADP
dti-1335	71	41	igf-1	igf-1	NOUN
dti-1335	71	42	stimulation	stimulation	NOUN
dti-1335	71	43	(	(	PUNCT
dti-1335	71	44	cheng	cheng	PROPN
dti-1335	71	45	et	et	PROPN
dti-1335	71	46	al	al	PROPN
dti-1335	71	47	.	.	PROPN
dti-1335	71	48	1999	1999	NUM
dti-1335	71	49	;	;	PUNCT
dti-1335	71	50	ogata	ogata	PROPN
dti-1335	71	51	et	et	PROPN
dti-1335	71	52	al	al	PROPN
dti-1335	71	53	.	.	PROPN
dti-1335	71	54	2004	2004	NUM
dti-1335	71	55	;	;	PUNCT
dti-1335	71	56	syroid	syroid	NOUN
dti-1335	71	57	et	et	PROPN
dti-1335	71	58	al	al	PROPN
dti-1335	71	59	.	.	PROPN
dti-1335	71	60	1999	1999	NUM
dti-1335	71	61	)	)	PUNCT
dti-1335	71	62	.	.	PUNCT
dti-1335	72	1	the	the	DET
dti-1335	72	2	importance	importance	NOUN
dti-1335	72	3	of	of	ADP
dti-1335	72	4	igf-1	igf-1	NOUN
dti-1335	72	5	in	in	ADP
dti-1335	72	6	myelin	myelin	ADJ
dti-1335	72	7	production	production	NOUN
dti-1335	72	8	has	have	AUX
dti-1335	72	9	also	also	ADV
dti-1335	72	10	been	be	AUX
dti-1335	72	11	demonstrated	demonstrate	VERB
dti-1335	72	12	in	in	ADP
dti-1335	72	13	several	several	ADJ
dti-1335	72	14	animal	animal	NOUN
dti-1335	72	15	models	model	NOUN
dti-1335	72	16	.	.	PUNCT
dti-1335	73	1	in	in	ADP
dti-1335	73	2	the	the	DET
dti-1335	73	3	cuprizone	cuprizone	NOUN
dti-1335	73	4	model	model	NOUN
dti-1335	73	5	,	,	PUNCT
dti-1335	73	6	demyelination	demyelination	NOUN
dti-1335	73	7	occurs	occur	VERB
dti-1335	73	8	in	in	ADP
dti-1335	73	9	the	the	DET
dti-1335	73	10	corpus	corpus	NOUN
dti-1335	73	11	callossum	callossum	NOUN
dti-1335	73	12	and	and	CCONJ
dti-1335	73	13	superior	superior	ADJ
dti-1335	73	14	cerebellar	cerebellar	ADJ
dti-1335	73	15	peduncles	peduncle	NOUN
dti-1335	73	16	,	,	PUNCT
dti-1335	73	17	and	and	CCONJ
dti-1335	73	18	remyelination	remyelination	NOUN
dti-1335	73	19	in	in	ADP
dti-1335	73	20	these	these	DET
dti-1335	73	21	areas	area	NOUN
dti-1335	73	22	ensues	ensue	VERB
dti-1335	73	23	when	when	SCONJ
dti-1335	73	24	treatment	treatment	NOUN
dti-1335	73	25	with	with	ADP
dti-1335	73	26	cuprizone	cuprizone	NOUN
dti-1335	73	27	is	be	AUX
dti-1335	73	28	terminated	terminate	VERB
dti-1335	73	29	.	.	PUNCT
dti-1335	74	1	cuprizone	cuprizone	NOUN
dti-1335	74	2	-	-	PUNCT
dti-1335	74	3	induced	induce	VERB
dti-1335	74	4	demyelination	demyelination	NOUN
dti-1335	74	5	in	in	ADP
dti-1335	74	6	mice	mice	NOUN
dti-1335	74	7	defi	defi	PROPN
dti-1335	74	8	cient	cient	PROPN
dti-1335	74	9	of	of	ADP
dti-1335	74	10	type-1	type-1	PROPN
dti-1335	74	11	igf	igf	NOUN
dti-1335	74	12	receptors	receptor	NOUN
dti-1335	74	13	has	have	AUX
dti-1335	74	14	demonstrated	demonstrate	VERB
dti-1335	74	15	inadequate	inadequate	ADJ
dti-1335	74	16	remyelination	remyelination	NOUN
dti-1335	74	17	and	and	CCONJ
dti-1335	74	18	lack	lack	NOUN
dti-1335	74	19	of	of	ADP
dti-1335	74	20	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	74	21	progenitor	progenitor	NOUN
dti-1335	74	22	cells	cell	NOUN
dti-1335	74	23	(	(	PUNCT
dti-1335	74	24	opc	opc	NOUN
dti-1335	74	25	)	)	PUNCT
dti-1335	74	26	accummulation	accummulation	NOUN
dti-1335	74	27	in	in	ADP
dti-1335	74	28	the	the	DET
dti-1335	74	29	site	site	NOUN
dti-1335	74	30	of	of	ADP
dti-1335	74	31	injury	injury	NOUN
dti-1335	74	32	(	(	PUNCT
dti-1335	74	33	mason	mason	PROPN
dti-1335	74	34	et	et	PROPN
dti-1335	74	35	al	al	PROPN
dti-1335	74	36	.	.	PROPN
dti-1335	74	37	2003	2003	NUM
dti-1335	74	38	)	)	PUNCT
dti-1335	74	39	.	.	PUNCT
dti-1335	75	1	transgenic	transgenic	NOUN
dti-1335	75	2	mice	mouse	NOUN
dti-1335	75	3	that	that	PRON
dti-1335	75	4	overexpress	overexpress	NOUN
dti-1335	75	5	igf-1	igf-1	NOUN
dti-1335	75	6	show	show	VERB
dti-1335	75	7	increased	increase	VERB
dti-1335	75	8	brain	brain	NOUN
dti-1335	75	9	growth	growth	NOUN
dti-1335	75	10	and	and	CCONJ
dti-1335	75	11	myelination	myelination	NOUN
dti-1335	75	12	(	(	PUNCT
dti-1335	75	13	carson	carson	PROPN
dti-1335	75	14	et	et	PROPN
dti-1335	75	15	al	al	PROPN
dti-1335	75	16	.	.	PROPN
dti-1335	75	17	1993	1993	NUM
dti-1335	75	18	)	)	PUNCT
dti-1335	75	19	.	.	PUNCT
dti-1335	76	1	myelin	myelin	NOUN
dti-1335	76	2	content	content	NOUN
dti-1335	76	3	in	in	ADP
dti-1335	76	4	these	these	DET
dti-1335	76	5	animals	animal	NOUN
dti-1335	76	6	was	be	AUX
dti-1335	76	7	increased	increase	VERB
dti-1335	76	8	by	by	ADP
dti-1335	76	9	130	130	NUM
dti-1335	76	10	%	%	NOUN
dti-1335	76	11	.	.	PUNCT
dti-1335	77	1	by	by	ADP
dti-1335	77	2	comparison	comparison	NOUN
dti-1335	77	3	,	,	PUNCT
dti-1335	77	4	igf-1	igf-1	NOUN
dti-1335	77	5	knock	knock	NOUN
dti-1335	77	6	-	-	PUNCT
dti-1335	77	7	out	out	ADP
dti-1335	77	8	mice	mouse	NOUN
dti-1335	77	9	displayed	display	VERB
dti-1335	77	10	reduced	reduced	ADJ
dti-1335	77	11	brain	brain	NOUN
dti-1335	77	12	size	size	NOUN
dti-1335	77	13	,	,	PUNCT
dti-1335	77	14	hypomyelination	hypomyelination	NOUN
dti-1335	77	15	,	,	PUNCT
dti-1335	77	16	reduced	reduce	VERB
dti-1335	77	17	density	density	NOUN
dti-1335	77	18	of	of	ADP
dti-1335	77	19	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	77	20	,	,	PUNCT
dti-1335	77	21	loss	loss	NOUN
dti-1335	77	22	of	of	ADP
dti-1335	77	23	neuron	neuron	NOUN
dti-1335	77	24	populations	population	NOUN
dti-1335	77	25	,	,	PUNCT
dti-1335	77	26	as	as	ADV
dti-1335	77	27	well	well	ADV
dti-1335	77	28	as	as	ADP
dti-1335	77	29	reduced	reduce	VERB
dti-1335	77	30	glucose	glucose	NOUN
dti-1335	77	31	uptake	uptake	NOUN
dti-1335	77	32	(	(	PUNCT
dti-1335	77	33	beck	beck	NOUN
dti-1335	77	34	et	et	PROPN
dti-1335	77	35	al	al	PROPN
dti-1335	77	36	.	.	PROPN
dti-1335	77	37	1995	1995	NUM
dti-1335	77	38	;	;	PUNCT
dti-1335	77	39	cheng	cheng	PROPN
dti-1335	77	40	et	et	PROPN
dti-1335	77	41	al	al	PROPN
dti-1335	77	42	.	.	PROPN
dti-1335	77	43	2000	2000	NUM
dti-1335	77	44	;	;	PUNCT
dti-1335	77	45	liu	liu	PROPN
dti-1335	77	46	et	et	PROPN
dti-1335	77	47	al	al	PROPN
dti-1335	77	48	.	.	PROPN
dti-1335	77	49	1993	1993	NUM
dti-1335	77	50	)	)	PUNCT
dti-1335	77	51	.	.	PUNCT
dti-1335	78	1	transgenic	transgenic	NOUN
dti-1335	78	2	mice	mouse	NOUN
dti-1335	78	3	overexpressing	overexpresse	VERB
dti-1335	78	4	igfbp-1	igfbp-1	PROPN
dti-1335	78	5	,	,	PUNCT
dti-1335	78	6	an	an	DET
dti-1335	78	7	inhibitory	inhibitory	ADJ
dti-1335	78	8	binding	bind	VERB
dti-1335	78	9	protein	protein	NOUN
dti-1335	78	10	for	for	ADP
dti-1335	78	11	igf-1	igf-1	PRON
dti-1335	78	12	,	,	PUNCT
dti-1335	78	13	showed	show	VERB
dti-1335	78	14	reduced	reduce	VERB
dti-1335	78	15	myelinated	myelinated	ADJ
dti-1335	78	16	axons	axon	NOUN
dti-1335	78	17	and	and	CCONJ
dti-1335	78	18	thickness	thickness	NOUN
dti-1335	78	19	of	of	ADP
dti-1335	78	20	the	the	DET
dti-1335	78	21	myelin	myelin	NOUN
dti-1335	78	22	sheets	sheet	NOUN
dti-1335	78	23	,	,	PUNCT
dti-1335	78	24	this	this	DET
dti-1335	78	25	feature	feature	NOUN
dti-1335	78	26	was	be	AUX
dti-1335	78	27	induced	induce	VERB
dti-1335	78	28	by	by	ADP
dti-1335	78	29	reduction	reduction	NOUN
dti-1335	78	30	in	in	ADP
dti-1335	78	31	myelin	myelin	ADJ
dti-1335	78	32	expression	expression	NOUN
dti-1335	78	33	(	(	PUNCT
dti-1335	78	34	ye	ye	INTJ
dti-1335	78	35	et	et	NOUN
dti-1335	78	36	al	al	PROPN
dti-1335	78	37	.	.	PROPN
dti-1335	78	38	1995	1995	NUM
dti-1335	78	39	)	)	PUNCT
dti-1335	78	40	.	.	PUNCT
dti-1335	79	1	other	other	ADJ
dti-1335	79	2	studies	study	NOUN
dti-1335	79	3	have	have	AUX
dti-1335	79	4	shown	show	VERB
dti-1335	79	5	that	that	SCONJ
dti-1335	79	6	systemic	systemic	ADJ
dti-1335	79	7	application	application	NOUN
dti-1335	79	8	of	of	ADP
dti-1335	79	9	igf-1	igf-1	NOUN
dti-1335	79	10	in	in	ADP
dti-1335	79	11	acute	acute	ADJ
dti-1335	79	12	demyelinating	demyelinate	VERB
dti-1335	79	13	experimental	experimental	ADJ
dti-1335	79	14	autoimmune	autoimmune	ADJ
dti-1335	79	15	encephalomyelitis	encephalomyelitis	NOUN
dti-1335	79	16	(	(	PUNCT
dti-1335	79	17	eae	eae	PROPN
dti-1335	79	18	)	)	PUNCT
dti-1335	79	19	,	,	PUNCT
dti-1335	79	20	an	an	DET
dti-1335	79	21	animal	animal	NOUN
dti-1335	79	22	model	model	NOUN
dti-1335	79	23	for	for	ADP
dti-1335	79	24	ms	ms	PROPN
dti-1335	79	25	,	,	PUNCT
dti-1335	79	26	signifi	signifi	NOUN
dti-1335	79	27	cantly	cantly	ADV
dti-1335	79	28	reduced	reduce	VERB
dti-1335	79	29	the	the	DET
dti-1335	79	30	number	number	NOUN
dti-1335	79	31	and	and	CCONJ
dti-1335	79	32	area	area	NOUN
dti-1335	79	33	of	of	ADP
dti-1335	79	34	the	the	DET
dti-1335	79	35	demyelinated	demyelinated	ADJ
dti-1335	79	36	lesions	lesion	NOUN
dti-1335	79	37	in	in	ADP
dti-1335	79	38	the	the	DET
dti-1335	79	39	spinal	spinal	ADJ
dti-1335	79	40	cord	cord	NOUN
dti-1335	79	41	(	(	PUNCT
dti-1335	79	42	liu	liu	PROPN
dti-1335	79	43	and	and	CCONJ
dti-1335	79	44	yao	yao	PROPN
dti-1335	79	45	,	,	PUNCT
dti-1335	79	46	1995	1995	NUM
dti-1335	79	47	;	;	PUNCT
dti-1335	79	48	yao	yao	PROPN
dti-1335	79	49	et	et	PROPN
dti-1335	79	50	al	al	PROPN
dti-1335	79	51	.	.	PROPN
dti-1335	79	52	1995	1995	NUM
dti-1335	79	53	)	)	PUNCT
dti-1335	79	54	.	.	PUNCT
dti-1335	80	1	igf-1	igf-1	PRON
dti-1335	80	2	increased	increase	VERB
dti-1335	80	3	the	the	DET
dti-1335	80	4	number	number	NOUN
dti-1335	80	5	of	of	ADP
dti-1335	80	6	remyelinated	remyelinate	VERB
dti-1335	80	7	axons	axon	NOUN
dti-1335	80	8	,	,	PUNCT
dti-1335	80	9	reduced	reduce	VERB
dti-1335	80	10	the	the	DET
dti-1335	80	11	permeability	permeability	NOUN
dti-1335	80	12	of	of	ADP
dti-1335	80	13	the	the	DET
dti-1335	80	14	blood	blood	NOUN
dti-1335	80	15	-	-	PUNCT
dti-1335	80	16	spinal	spinal	NOUN
dti-1335	80	17	cord	cord	NOUN
dti-1335	80	18	barrier	barrier	NOUN
dti-1335	80	19	,	,	PUNCT
dti-1335	80	20	and	and	CCONJ
dti-1335	80	21	enhanced	enhance	VERB
dti-1335	80	22	myelin	myelin	NOUN
dti-1335	80	23	expression	expression	NOUN
dti-1335	80	24	.	.	PUNCT
dti-1335	81	1	however	however	ADV
dti-1335	81	2	,	,	PUNCT
dti-1335	81	3	in	in	ADP
dti-1335	81	4	chronic	chronic	NOUN
dti-1335	81	5	-	-	PUNCT
dti-1335	81	6	relapsing	relapse	VERB
dti-1335	81	7	eae	eae	NOUN
dti-1335	81	8	,	,	PUNCT
dti-1335	81	9	systemic	systemic	ADJ
dti-1335	81	10	administration	administration	NOUN
dti-1335	81	11	of	of	ADP
dti-1335	81	12	igf-1	igf-1	NOUN
dti-1335	81	13	together	together	ADV
dti-1335	81	14	with	with	ADP
dti-1335	81	15	igfbp-3	igfbp-3	NUM
dti-1335	81	16	after	after	SCONJ
dti-1335	81	17	disease	disease	NOUN
dti-1335	81	18	onset	onset	NOUN
dti-1335	81	19	resulted	result	VERB
dti-1335	81	20	in	in	ADP
dti-1335	81	21	increased	increase	VERB
dti-1335	81	22	severity	severity	NOUN
dti-1335	81	23	and	and	CCONJ
dti-1335	81	24	or	or	CCONJ
dti-1335	81	25	relapses	relapse	NOUN
dti-1335	81	26	(	(	PUNCT
dti-1335	81	27	lovett	lovett	PROPN
dti-1335	81	28	-	-	PUNCT
dti-1335	81	29	racke	racke	PROPN
dti-1335	81	30	et	et	PROPN
dti-1335	81	31	al	al	PROPN
dti-1335	81	32	.	.	PROPN
dti-1335	81	33	1998	1998	NUM
dti-1335	81	34	)	)	PUNCT
dti-1335	81	35	.	.	PUNCT
dti-1335	82	1	in	in	ADP
dti-1335	82	2	line	line	NOUN
dti-1335	82	3	40	40	NUM
dti-1335	82	4	wilczak	wilczak	NOUN
dti-1335	82	5	et	et	NOUN
dti-1335	82	6	al	al	PROPN
dti-1335	82	7	drug	drug	PROPN
dti-1335	82	8	target	target	NOUN
dti-1335	82	9	insights	insight	NOUN
dti-1335	82	10	2008:3	2008:3	NUM
dti-1335	82	11	with	with	ADP
dti-1335	82	12	these	these	DET
dti-1335	82	13	results	result	NOUN
dti-1335	82	14	,	,	PUNCT
dti-1335	82	15	long	long	ADJ
dti-1335	82	16	-	-	PUNCT
dti-1335	82	17	term	term	NOUN
dti-1335	82	18	application	application	NOUN
dti-1335	82	19	of	of	ADP
dti-1335	82	20	igf-1	igf-1	NOUN
dti-1335	82	21	in	in	ADP
dti-1335	82	22	chronicrelapsing	chronicrelapse	VERB
dti-1335	82	23	eae	eae	NOUN
dti-1335	82	24	from	from	ADP
dti-1335	82	25	the	the	DET
dti-1335	82	26	standpoint	standpoint	NOUN
dti-1335	82	27	of	of	ADP
dti-1335	82	28	myelin	myelin	ADJ
dti-1335	82	29	gene	gene	NOUN
dti-1335	82	30	expression	expression	NOUN
dti-1335	82	31	and	and	CCONJ
dti-1335	82	32	repair	repair	NOUN
dti-1335	82	33	,	,	PUNCT
dti-1335	82	34	showed	show	VERB
dti-1335	82	35	no	no	DET
dti-1335	82	36	positive	positive	ADJ
dti-1335	82	37	effects	effect	NOUN
dti-1335	82	38	of	of	ADP
dti-1335	82	39	igf-1	igf-1	PRON
dti-1335	82	40	(	(	PUNCT
dti-1335	82	41	canella	canella	PROPN
dti-1335	82	42	et	et	PROPN
dti-1335	82	43	al	al	PROPN
dti-1335	82	44	.	.	PROPN
dti-1335	82	45	2000	2000	NUM
dti-1335	82	46	)	)	PUNCT
dti-1335	82	47	.	.	PUNCT
dti-1335	83	1	in	in	ADP
dti-1335	83	2	a	a	DET
dti-1335	83	3	clinical	clinical	ADJ
dti-1335	83	4	trial	trial	NOUN
dti-1335	83	5	with	with	ADP
dti-1335	83	6	systemically	systemically	ADV
dti-1335	83	7	administered	administer	VERB
dti-1335	83	8	recombinant	recombinant	ADJ
dti-1335	83	9	igf-1	igf-1	ADV
dti-1335	83	10	in	in	ADP
dti-1335	83	11	ms	ms	ADJ
dti-1335	83	12	patients	patient	NOUN
dti-1335	83	13	,	,	PUNCT
dti-1335	83	14	no	no	DET
dti-1335	83	15	effects	effect	NOUN
dti-1335	83	16	on	on	ADP
dti-1335	83	17	either	either	CCONJ
dti-1335	83	18	new	new	ADJ
dti-1335	83	19	lesion	lesion	NOUN
dti-1335	83	20	formation	formation	NOUN
dti-1335	83	21	or	or	CCONJ
dti-1335	83	22	remyelination	remyelination	NOUN
dti-1335	83	23	of	of	ADP
dti-1335	83	24	existing	exist	VERB
dti-1335	83	25	lesions	lesion	NOUN
dti-1335	83	26	could	could	AUX
dti-1335	83	27	be	be	AUX
dti-1335	83	28	demonstrated	demonstrate	VERB
dti-1335	83	29	(	(	PUNCT
dti-1335	83	30	frank	frank	PROPN
dti-1335	83	31	et	et	PROPN
dti-1335	83	32	al	al	PROPN
dti-1335	83	33	.	.	PROPN
dti-1335	83	34	2002	2002	NUM
dti-1335	83	35	)	)	PUNCT
dti-1335	83	36	.	.	PUNCT
dti-1335	84	1	data	datum	NOUN
dti-1335	84	2	from	from	ADP
dti-1335	84	3	this	this	DET
dti-1335	84	4	clinical	clinical	ADJ
dti-1335	84	5	trial	trial	NOUN
dti-1335	84	6	,	,	PUNCT
dti-1335	84	7	as	as	ADV
dti-1335	84	8	well	well	ADV
dti-1335	84	9	as	as	ADP
dti-1335	84	10	from	from	ADP
dti-1335	84	11	the	the	DET
dti-1335	84	12	above	above	ADV
dti-1335	84	13	mentioned	mention	VERB
dti-1335	84	14	study	study	NOUN
dti-1335	84	15	on	on	ADP
dti-1335	84	16	chronic	chronic	ADJ
dti-1335	84	17	relapsing	relapse	VERB
dti-1335	84	18	eae	eae	PROPN
dti-1335	84	19	raise	raise	VERB
dti-1335	84	20	doubts	doubt	NOUN
dti-1335	84	21	about	about	ADP
dti-1335	84	22	the	the	DET
dti-1335	84	23	effectiveness	effectiveness	NOUN
dti-1335	84	24	of	of	ADP
dti-1335	84	25	systemic	systemic	ADJ
dti-1335	84	26	administered	administer	VERB
dti-1335	84	27	igf-1	igf-1	NOUN
dti-1335	84	28	in	in	ADP
dti-1335	84	29	chronic	chronic	ADJ
dti-1335	84	30	forms	form	NOUN
dti-1335	84	31	of	of	ADP
dti-1335	84	32	demyelination	demyelination	NOUN
dti-1335	84	33	.	.	PUNCT
dti-1335	85	1	in	in	ADP
dti-1335	85	2	the	the	DET
dti-1335	85	3	following	follow	VERB
dti-1335	85	4	sections	section	NOUN
dti-1335	85	5	,	,	PUNCT
dti-1335	85	6	we	we	PRON
dti-1335	85	7	dicuss	dicuss	VERB
dti-1335	85	8	several	several	ADJ
dti-1335	85	9	obstacles	obstacle	NOUN
dti-1335	85	10	that	that	PRON
dti-1335	85	11	might	might	AUX
dti-1335	85	12	explain	explain	VERB
dti-1335	85	13	a	a	DET
dti-1335	85	14	lack	lack	NOUN
dti-1335	85	15	of	of	ADP
dti-1335	85	16	benefi	benefi	PROPN
dti-1335	85	17	cial	cial	ADJ
dti-1335	85	18	effects	effect	NOUN
dti-1335	85	19	of	of	ADP
dti-1335	85	20	systemic	systemic	ADJ
dti-1335	85	21	administered	administer	VERB
dti-1335	85	22	igf-1	igf-1	NOUN
dti-1335	85	23	.	.	PUNCT
dti-1335	85	24	enhancing	enhance	VERB
dti-1335	85	25	the	the	DET
dti-1335	85	26	level	level	NOUN
dti-1335	85	27	of	of	ADP
dti-1335	85	28	free	free	ADJ
dti-1335	85	29	igf-1	igf-1	ADV
dti-1335	85	30	and	and	CCONJ
dti-1335	85	31	targeting	target	VERB
dti-1335	85	32	igf-1	igf-1	NOUN
dti-1335	85	33	into	into	ADP
dti-1335	85	34	the	the	DET
dti-1335	85	35	cns	cns	NOUN
dti-1335	85	36	one	one	NUM
dti-1335	85	37	possible	possible	ADJ
dti-1335	85	38	obstacle	obstacle	NOUN
dti-1335	85	39	in	in	ADP
dti-1335	85	40	an	an	DET
dti-1335	85	41	igf-1	igf-1	ADV
dti-1335	85	42	based	base	VERB
dti-1335	85	43	therapy	therapy	NOUN
dti-1335	85	44	is	be	AUX
dti-1335	85	45	the	the	DET
dti-1335	85	46	limited	limited	ADJ
dti-1335	85	47	penetration	penetration	NOUN
dti-1335	85	48	across	across	ADP
dti-1335	85	49	the	the	DET
dti-1335	85	50	blood	blood	NOUN
dti-1335	85	51	brain	brain	NOUN
dti-1335	85	52	barrier	barrier	NOUN
dti-1335	85	53	(	(	PUNCT
dti-1335	85	54	bbb	bbb	NOUN
dti-1335	85	55	)	)	PUNCT
dti-1335	85	56	that	that	PRON
dti-1335	85	57	prevents	prevent	VERB
dti-1335	85	58	free	free	ADJ
dti-1335	85	59	passage	passage	NOUN
dti-1335	85	60	of	of	ADP
dti-1335	85	61	large	large	ADJ
dti-1335	85	62	proteins	protein	NOUN
dti-1335	85	63	into	into	ADP
dti-1335	85	64	the	the	DET
dti-1335	85	65	cns	cns	NOUN
dti-1335	85	66	.	.	PUNCT
dti-1335	86	1	however	however	ADV
dti-1335	86	2	,	,	PUNCT
dti-1335	86	3	there	there	PRON
dti-1335	86	4	is	be	VERB
dti-1335	86	5	some	some	DET
dti-1335	86	6	evidence	evidence	NOUN
dti-1335	86	7	that	that	SCONJ
dti-1335	86	8	igf-1	igf-1	VERB
dti-1335	86	9	from	from	ADP
dti-1335	86	10	the	the	DET
dti-1335	86	11	circulation	circulation	NOUN
dti-1335	86	12	might	might	AUX
dti-1335	86	13	be	be	AUX
dti-1335	86	14	transported	transport	VERB
dti-1335	86	15	across	across	ADP
dti-1335	86	16	these	these	DET
dti-1335	86	17	barriers	barrier	NOUN
dti-1335	86	18	,	,	PUNCT
dti-1335	86	19	albeit	albeit	SCONJ
dti-1335	86	20	to	to	ADP
dti-1335	86	21	a	a	DET
dti-1335	86	22	limited	limited	ADJ
dti-1335	86	23	extent	extent	NOUN
dti-1335	86	24	.	.	PUNCT
dti-1335	87	1	one	one	NUM
dti-1335	87	2	possible	possible	ADJ
dti-1335	87	3	mechanism	mechanism	NOUN
dti-1335	87	4	to	to	PART
dti-1335	87	5	transport	transport	VERB
dti-1335	87	6	igf-1	igf-1	NOUN
dti-1335	87	7	from	from	ADP
dti-1335	87	8	the	the	DET
dti-1335	87	9	circulation	circulation	NOUN
dti-1335	87	10	into	into	ADP
dti-1335	87	11	the	the	DET
dti-1335	87	12	cns	cns	NOUN
dti-1335	87	13	is	be	AUX
dti-1335	87	14	throughreceptor	throughreceptor	NOUN
dti-1335	87	15	mediated	mediate	VERB
dti-1335	87	16	transcytosis	transcytosis	NOUN
dti-1335	87	17	(	(	PUNCT
dti-1335	87	18	reinhardt	reinhardt	NOUN
dti-1335	87	19	and	and	CCONJ
dti-1335	87	20	bondy	bondy	PROPN
dti-1335	87	21	,	,	PUNCT
dti-1335	87	22	1994	1994	NUM
dti-1335	87	23	)	)	PUNCT
dti-1335	87	24	.	.	PUNCT
dti-1335	88	1	however	however	ADV
dti-1335	88	2	,	,	PUNCT
dti-1335	88	3	it	it	PRON
dti-1335	88	4	is	be	AUX
dti-1335	88	5	still	still	ADV
dti-1335	88	6	not	not	PART
dti-1335	88	7	clear	clear	ADJ
dti-1335	88	8	which	which	DET
dti-1335	88	9	receptor	receptor	NOUN
dti-1335	88	10	is	be	AUX
dti-1335	88	11	involved	involve	VERB
dti-1335	88	12	in	in	ADP
dti-1335	88	13	such	such	ADJ
dti-1335	88	14	transport	transport	NOUN
dti-1335	88	15	system	system	NOUN
dti-1335	88	16	.	.	PUNCT
dti-1335	89	1	it	it	PRON
dti-1335	89	2	has	have	AUX
dti-1335	89	3	been	be	AUX
dti-1335	89	4	suggested	suggest	VERB
dti-1335	89	5	that	that	SCONJ
dti-1335	89	6	the	the	DET
dti-1335	89	7	presence	presence	NOUN
dti-1335	89	8	of	of	ADP
dti-1335	89	9	type-1	type-1	PROPN
dti-1335	89	10	igf	igf	NOUN
dti-1335	89	11	receptors	receptor	NOUN
dti-1335	89	12	on	on	ADP
dti-1335	89	13	the	the	DET
dti-1335	89	14	endothelium	endothelium	NOUN
dti-1335	89	15	might	might	AUX
dti-1335	89	16	play	play	VERB
dti-1335	89	17	a	a	DET
dti-1335	89	18	role	role	NOUN
dti-1335	89	19	in	in	ADP
dti-1335	89	20	such	such	ADJ
dti-1335	89	21	transport	transport	NOUN
dti-1335	89	22	.	.	PUNCT
dti-1335	90	1	the	the	DET
dti-1335	90	2	transport	transport	NOUN
dti-1335	90	3	of	of	ADP
dti-1335	90	4	peripheral	peripheral	ADJ
dti-1335	90	5	igf-1	igf-1	NOUN
dti-1335	90	6	into	into	ADP
dti-1335	90	7	the	the	DET
dti-1335	90	8	cns	cns	NOUN
dti-1335	90	9	may	may	AUX
dti-1335	90	10	also	also	ADV
dti-1335	90	11	be	be	AUX
dti-1335	90	12	infl	infl	PROPN
dti-1335	90	13	uenced	uence	VERB
dti-1335	90	14	by	by	ADP
dti-1335	90	15	igfbps	igfbps	NOUN
dti-1335	90	16	which	which	PRON
dti-1335	90	17	become	become	VERB
dti-1335	90	18	saturable	saturable	ADJ
dti-1335	90	19	at	at	ADP
dti-1335	90	20	the	the	DET
dti-1335	90	21	bbb	bbb	PROPN
dti-1335	90	22	(	(	PUNCT
dti-1335	90	23	weihong	weihong	NOUN
dti-1335	90	24	and	and	CCONJ
dti-1335	90	25	kastin	kastin	PROPN
dti-1335	90	26	,	,	PUNCT
dti-1335	90	27	2000	2000	NUM
dti-1335	90	28	)	)	PUNCT
dti-1335	90	29	.	.	PUNCT
dti-1335	91	1	other	other	ADJ
dti-1335	91	2	studies	study	NOUN
dti-1335	91	3	have	have	AUX
dti-1335	91	4	shown	show	VERB
dti-1335	91	5	that	that	SCONJ
dti-1335	91	6	the	the	DET
dti-1335	91	7	uptake	uptake	NOUN
dti-1335	91	8	of	of	ADP
dti-1335	91	9	circulating	circulate	VERB
dti-1335	91	10	igfs	igf	NOUN
dti-1335	91	11	into	into	ADP
dti-1335	91	12	cerebrospinal	cerebrospinal	ADJ
dti-1335	91	13	fl	fl	X
dti-1335	91	14	uid	uid	ADJ
dti-1335	91	15	(	(	PUNCT
dti-1335	91	16	csf	csf	PROPN
dti-1335	91	17	)	)	PUNCT
dti-1335	91	18	and	and	CCONJ
dti-1335	91	19	probably	probably	ADV
dti-1335	91	20	into	into	ADP
dti-1335	91	21	the	the	DET
dti-1335	91	22	cns	cns	NOUN
dti-1335	91	23	appears	appear	VERB
dti-1335	91	24	to	to	PART
dti-1335	91	25	be	be	AUX
dti-1335	91	26	independent	independent	ADJ
dti-1335	91	27	of	of	ADP
dti-1335	91	28	type-1	type-1	PROPN
dti-1335	91	29	igf	igf	NOUN
dti-1335	91	30	receptors	receptor	NOUN
dti-1335	91	31	as	as	ADV
dti-1335	91	32	well	well	ADV
dti-1335	91	33	as	as	ADP
dti-1335	91	34	igf	igf	NOUN
dti-1335	91	35	-	-	ADJ
dti-1335	91	36	binding	binding	ADJ
dti-1335	91	37	proteins	protein	NOUN
dti-1335	91	38	.	.	PUNCT
dti-1335	92	1	there	there	PRON
dti-1335	92	2	is	be	VERB
dti-1335	92	3	evidence	evidence	NOUN
dti-1335	92	4	that	that	SCONJ
dti-1335	92	5	choroid	choroid	NOUN
dti-1335	92	6	plexus	plexus	NOUN
dti-1335	92	7	megalin	megalin	NOUN
dti-1335	92	8	is	be	AUX
dti-1335	92	9	involved	involve	VERB
dti-1335	92	10	in	in	ADP
dti-1335	92	11	neuroprotection	neuroprotection	NOUN
dti-1335	92	12	by	by	ADP
dti-1335	92	13	serum	serum	NOUN
dti-1335	92	14	igf-1	igf-1	NOUN
dti-1335	92	15	in	in	ADP
dti-1335	92	16	alzheimer	alzheimer	PROPN
dti-1335	92	17	disease	disease	NOUN
dti-1335	92	18	by	by	ADP
dti-1335	92	19	its	its	PRON
dti-1335	92	20	dual	dual	ADJ
dti-1335	92	21	effects	effect	NOUN
dti-1335	92	22	on	on	ADP
dti-1335	92	23	transporting	transport	VERB
dti-1335	92	24	igf-1	igf-1	NOUN
dti-1335	92	25	in	in	ADV
dti-1335	92	26	across	across	ADP
dti-1335	92	27	the	the	DET
dti-1335	92	28	bbb	bbb	NOUN
dti-1335	92	29	,	,	PUNCT
dti-1335	92	30	and	and	CCONJ
dti-1335	92	31	by	by	ADP
dti-1335	92	32	enhancing	enhance	VERB
dti-1335	92	33	the	the	DET
dti-1335	92	34	clearance	clearance	NOUN
dti-1335	92	35	of	of	ADP
dti-1335	92	36	brain	brain	NOUN
dti-1335	92	37	amyloidβ	amyloidβ	NOUN
dti-1335	92	38	(	(	PUNCT
dti-1335	92	39	carro	carro	PROPN
dti-1335	92	40	et	et	PROPN
dti-1335	92	41	al	al	PROPN
dti-1335	92	42	.	.	PROPN
dti-1335	92	43	2005	2005	NUM
dti-1335	92	44	)	)	PUNCT
dti-1335	92	45	.	.	PUNCT
dti-1335	93	1	however	however	ADV
dti-1335	93	2	,	,	PUNCT
dti-1335	93	3	it	it	PRON
dti-1335	93	4	remains	remain	VERB
dti-1335	93	5	questionable	questionable	ADJ
dti-1335	93	6	whether	whether	SCONJ
dti-1335	93	7	systemic	systemic	ADJ
dti-1335	93	8	levels	level	NOUN
dti-1335	93	9	of	of	ADP
dti-1335	93	10	igf-1	igf-1	X
dti-1335	93	11	would	would	AUX
dti-1335	93	12	indeed	indeed	ADV
dti-1335	93	13	raise	raise	VERB
dti-1335	93	14	ligand	ligand	ADJ
dti-1335	93	15	levels	level	NOUN
dti-1335	93	16	in	in	ADP
dti-1335	93	17	the	the	DET
dti-1335	93	18	deep	deep	ADJ
dti-1335	93	19	white	white	ADJ
dti-1335	93	20	matter	matter	NOUN
dti-1335	93	21	of	of	ADP
dti-1335	93	22	the	the	DET
dti-1335	93	23	cns	cns	NOUN
dti-1335	93	24	in	in	ADP
dti-1335	93	25	which	which	PRON
dti-1335	93	26	demyelination	demyelination	NOUN
dti-1335	93	27	occurs	occur	VERB
dti-1335	93	28	.	.	PUNCT
dti-1335	94	1	the	the	DET
dti-1335	94	2	amount	amount	NOUN
dti-1335	94	3	of	of	ADP
dti-1335	94	4	igf-1	igf-1	NOUN
dti-1335	94	5	eventually	eventually	ADV
dti-1335	94	6	reaching	reach	VERB
dti-1335	94	7	the	the	DET
dti-1335	94	8	deep	deep	ADJ
dti-1335	94	9	white	white	ADJ
dti-1335	94	10	matter	matter	NOUN
dti-1335	94	11	will	will	AUX
dti-1335	94	12	depend	depend	VERB
dti-1335	94	13	on	on	ADP
dti-1335	94	14	the	the	DET
dti-1335	94	15	concentration	concentration	NOUN
dti-1335	94	16	of	of	ADP
dti-1335	94	17	circulating	circulate	VERB
dti-1335	94	18	igf-1	igf-1	PUNCT
dti-1335	94	19	and	and	CCONJ
dti-1335	94	20	how	how	SCONJ
dti-1335	94	21	avidly	avidly	ADV
dti-1335	94	22	the	the	DET
dti-1335	94	23	bbb	bbb	PROPN
dti-1335	94	24	transport	transport	NOUN
dti-1335	94	25	system	system	NOUN
dti-1335	94	26	uptakes	uptake	VERB
dti-1335	94	27	it	it	PRON
dti-1335	94	28	.	.	PUNCT
dti-1335	95	1	approaches	approach	VERB
dti-1335	95	2	that	that	PRON
dti-1335	95	3	bypass	bypass	VERB
dti-1335	95	4	the	the	DET
dti-1335	95	5	bbb	bbb	NOUN
dti-1335	95	6	and	and	CCONJ
dti-1335	95	7	show	show	VERB
dti-1335	95	8	that	that	SCONJ
dti-1335	95	9	igf-1	igf-1	PRON
dti-1335	95	10	has	have	VERB
dti-1335	95	11	neuroprotective	neuroprotective	ADJ
dti-1335	95	12	effects	effect	NOUN
dti-1335	95	13	in	in	ADP
dti-1335	95	14	the	the	DET
dti-1335	95	15	cns	cns	NOUN
dti-1335	95	16	of	of	ADP
dti-1335	95	17	animals	animal	NOUN
dti-1335	95	18	use	use	VERB
dti-1335	95	19	surgically	surgically	ADV
dti-1335	95	20	invasive	invasive	ADJ
dti-1335	95	21	procedures	procedure	NOUN
dti-1335	95	22	,	,	PUNCT
dti-1335	95	23	such	such	ADJ
dti-1335	95	24	as	as	ADP
dti-1335	95	25	the	the	DET
dti-1335	95	26	intracerebrovascular	intracerebrovascular	ADJ
dti-1335	95	27	or	or	CCONJ
dti-1335	95	28	intraparenchymal	intraparenchymal	ADJ
dti-1335	95	29	administration	administration	NOUN
dti-1335	95	30	.	.	PUNCT
dti-1335	96	1	these	these	DET
dti-1335	96	2	methods	method	NOUN
dti-1335	96	3	are	be	AUX
dti-1335	96	4	not	not	PART
dti-1335	96	5	applicable	applicable	ADJ
dti-1335	96	6	to	to	ADP
dti-1335	96	7	ms	ms	NOUN
dti-1335	96	8	patients	patient	NOUN
dti-1335	96	9	but	but	CCONJ
dti-1335	96	10	do	do	AUX
dti-1335	96	11	demonstrate	demonstrate	VERB
dti-1335	96	12	a	a	DET
dti-1335	96	13	need	need	NOUN
dti-1335	96	14	for	for	ADP
dti-1335	96	15	targeting	target	VERB
dti-1335	96	16	.	.	PUNCT
dti-1335	97	1	intranasal	intranasal	PROPN
dti-1335	97	2	administration	administration	PROPN
dti-1335	97	3	of	of	ADP
dti-1335	97	4	igf-1	igf-1	NOUN
dti-1335	97	5	offers	offer	VERB
dti-1335	97	6	an	an	DET
dti-1335	97	7	alternative	alternative	ADJ
dti-1335	97	8	strategy	strategy	NOUN
dti-1335	97	9	to	to	PART
dti-1335	97	10	bypass	bypass	VERB
dti-1335	97	11	the	the	DET
dti-1335	97	12	bbb	bbb	NOUN
dti-1335	97	13	and	and	CCONJ
dti-1335	97	14	is	be	AUX
dti-1335	97	15	a	a	DET
dti-1335	97	16	method	method	NOUN
dti-1335	97	17	that	that	PRON
dti-1335	97	18	provides	provide	VERB
dti-1335	97	19	several	several	ADJ
dti-1335	97	20	advantages	advantage	NOUN
dti-1335	97	21	;	;	PUNCT
dti-1335	97	22	it	it	PRON
dti-1335	97	23	is	be	AUX
dti-1335	97	24	a	a	DET
dti-1335	97	25	non	non	ADJ
dti-1335	97	26	-	-	ADJ
dti-1335	97	27	invasive	invasive	ADJ
dti-1335	97	28	way	way	NOUN
dti-1335	97	29	of	of	ADP
dti-1335	97	30	drug	drug	NOUN
dti-1335	97	31	application	application	NOUN
dti-1335	97	32	,	,	PUNCT
dti-1335	97	33	there	there	PRON
dti-1335	97	34	is	be	VERB
dti-1335	97	35	a	a	DET
dti-1335	97	36	direct	direct	ADJ
dti-1335	97	37	delivery	delivery	NOUN
dti-1335	97	38	of	of	ADP
dti-1335	97	39	the	the	DET
dti-1335	97	40	drug	drug	NOUN
dti-1335	97	41	into	into	ADP
dti-1335	97	42	the	the	DET
dti-1335	97	43	cns	cns	NOUN
dti-1335	97	44	,	,	PUNCT
dti-1335	97	45	levels	level	NOUN
dti-1335	97	46	of	of	ADP
dti-1335	97	47	the	the	DET
dti-1335	97	48	drugs	drug	NOUN
dti-1335	97	49	are	be	AUX
dti-1335	97	50	more	more	ADV
dti-1335	97	51	concentrated	concentrated	ADJ
dti-1335	97	52	by	by	ADP
dti-1335	97	53	avoiding	avoid	VERB
dti-1335	97	54	the	the	DET
dti-1335	97	55	diluting	diluting	ADJ
dti-1335	97	56	effects	effect	NOUN
dti-1335	97	57	of	of	ADP
dti-1335	97	58	the	the	DET
dti-1335	97	59	circulation	circulation	NOUN
dti-1335	97	60	,	,	PUNCT
dti-1335	97	61	and	and	CCONJ
dti-1335	97	62	degradation	degradation	NOUN
dti-1335	97	63	and	and	CCONJ
dti-1335	97	64	destruction	destruction	NOUN
dti-1335	97	65	of	of	ADP
dti-1335	97	66	drugs	drug	NOUN
dti-1335	97	67	are	be	AUX
dti-1335	97	68	minimized	minimize	VERB
dti-1335	97	69	by	by	ADP
dti-1335	97	70	avoiding	avoid	VERB
dti-1335	97	71	the	the	DET
dti-1335	97	72	gastrointestinal	gastrointestinal	ADJ
dti-1335	97	73	tracts	tract	NOUN
dti-1335	97	74	.	.	PUNCT
dti-1335	98	1	thorne	thorne	PROPN
dti-1335	98	2	and	and	CCONJ
dti-1335	98	3	co	co	NOUN
dti-1335	98	4	-	-	NOUN
dti-1335	98	5	workers	worker	NOUN
dti-1335	98	6	have	have	AUX
dti-1335	98	7	demonstrated	demonstrate	VERB
dti-1335	98	8	that	that	SCONJ
dti-1335	98	9	intranasal	intranasal	ADJ
dti-1335	98	10	application	application	NOUN
dti-1335	98	11	of	of	ADP
dti-1335	98	12	igf-1	igf-1	NOUN
dti-1335	98	13	results	result	NOUN
dti-1335	98	14	in	in	ADP
dti-1335	98	15	a	a	DET
dti-1335	98	16	rapid	rapid	ADJ
dti-1335	98	17	delivery	delivery	NOUN
dti-1335	98	18	of	of	ADP
dti-1335	98	19	igf-1	igf-1	NOUN
dti-1335	98	20	into	into	ADP
dti-1335	98	21	multiple	multiple	ADJ
dti-1335	98	22	areas	area	NOUN
dti-1335	98	23	of	of	ADP
dti-1335	98	24	the	the	DET
dti-1335	98	25	cns	cns	NOUN
dti-1335	98	26	,	,	PUNCT
dti-1335	98	27	including	include	VERB
dti-1335	98	28	the	the	DET
dti-1335	98	29	deep	deep	ADJ
dti-1335	98	30	white	white	ADJ
dti-1335	98	31	matter	matter	NOUN
dti-1335	98	32	in	in	ADP
dti-1335	98	33	which	which	PRON
dti-1335	98	34	demyelination	demyelination	NOUN
dti-1335	98	35	can	can	AUX
dti-1335	98	36	occur	occur	VERB
dti-1335	98	37	(	(	PUNCT
dti-1335	98	38	thorne	thorne	NOUN
dti-1335	98	39	et	et	PROPN
dti-1335	98	40	al	al	PROPN
dti-1335	98	41	.	.	PROPN
dti-1335	98	42	2004	2004	NUM
dti-1335	98	43	)	)	PUNCT
dti-1335	98	44	.	.	PUNCT
dti-1335	99	1	in	in	ADP
dti-1335	99	2	this	this	DET
dti-1335	99	3	study	study	NOUN
dti-1335	99	4	,	,	PUNCT
dti-1335	99	5	igf-1	igf-1	PRON
dti-1335	99	6	was	be	AUX
dti-1335	99	7	delivered	deliver	VERB
dti-1335	99	8	from	from	ADP
dti-1335	99	9	the	the	DET
dti-1335	99	10	nasal	nasal	ADJ
dti-1335	99	11	cavity	cavity	NOUN
dti-1335	99	12	along	along	ADP
dti-1335	99	13	olfactory	olfactory	NOUN
dti-1335	99	14	and	and	CCONJ
dti-1335	99	15	trigeminal	trigeminal	ADJ
dti-1335	99	16	pathways	pathway	NOUN
dti-1335	99	17	and	and	CCONJ
dti-1335	99	18	was	be	AUX
dti-1335	99	19	accompanied	accompany	VERB
dti-1335	99	20	by	by	ADP
dti-1335	99	21	activation	activation	NOUN
dti-1335	99	22	of	of	ADP
dti-1335	99	23	signaling	signal	VERB
dti-1335	99	24	pathways	pathway	NOUN
dti-1335	99	25	in	in	ADP
dti-1335	99	26	several	several	ADJ
dti-1335	99	27	areas	area	NOUN
dti-1335	99	28	that	that	PRON
dti-1335	99	29	express	express	VERB
dti-1335	99	30	high	high	ADJ
dti-1335	99	31	levels	level	NOUN
dti-1335	99	32	of	of	ADP
dti-1335	99	33	type-1	type-1	PROPN
dti-1335	99	34	igf	igf	NOUN
dti-1335	99	35	receptors	receptor	NOUN
dti-1335	99	36	.	.	PUNCT
dti-1335	100	1	thorne	thorne	PROPN
dti-1335	100	2	and	and	CCONJ
dti-1335	100	3	coworkers	coworker	NOUN
dti-1335	100	4	suggested	suggest	VERB
dti-1335	100	5	an	an	DET
dti-1335	100	6	extracellular	extracellular	ADJ
dti-1335	100	7	route	route	NOUN
dti-1335	100	8	of	of	ADP
dti-1335	100	9	transportation	transportation	NOUN
dti-1335	100	10	from	from	ADP
dti-1335	100	11	the	the	DET
dti-1335	100	12	nasal	nasal	ADJ
dti-1335	100	13	passages	passage	NOUN
dti-1335	100	14	into	into	ADP
dti-1335	100	15	the	the	DET
dti-1335	100	16	cns	cns	NOUN
dti-1335	100	17	associated	associate	VERB
dti-1335	100	18	with	with	ADP
dti-1335	100	19	components	component	NOUN
dti-1335	100	20	of	of	ADP
dti-1335	100	21	the	the	DET
dti-1335	100	22	trigeminal	trigeminal	ADJ
dti-1335	100	23	nerve	nerve	NOUN
dti-1335	100	24	.	.	PUNCT
dti-1335	101	1	this	this	DET
dti-1335	101	2	mode	mode	NOUN
dti-1335	101	3	of	of	ADP
dti-1335	101	4	transport	transport	NOUN
dti-1335	101	5	provides	provide	VERB
dti-1335	101	6	evidence	evidence	NOUN
dti-1335	101	7	for	for	ADP
dti-1335	101	8	a	a	DET
dti-1335	101	9	rapid	rapid	ADJ
dti-1335	101	10	and	and	CCONJ
dti-1335	101	11	direct	direct	ADJ
dti-1335	101	12	pathway	pathway	NOUN
dti-1335	101	13	for	for	ADP
dti-1335	101	14	protein	protein	NOUN
dti-1335	101	15	transport	transport	NOUN
dti-1335	101	16	into	into	ADP
dti-1335	101	17	the	the	DET
dti-1335	101	18	cns	cns	NOUN
dti-1335	101	19	following	follow	VERB
dti-1335	101	20	intranasal	intranasal	ADJ
dti-1335	101	21	administration	administration	NOUN
dti-1335	101	22	.	.	PUNCT
dti-1335	102	1	a	a	DET
dti-1335	102	2	second	second	ADJ
dti-1335	102	3	obstacle	obstacle	NOUN
dti-1335	102	4	in	in	ADP
dti-1335	102	5	an	an	DET
dti-1335	102	6	igf-1	igf-1	ADV
dti-1335	102	7	based	base	VERB
dti-1335	102	8	therapy	therapy	NOUN
dti-1335	102	9	lies	lie	VERB
dti-1335	102	10	in	in	ADP
dti-1335	102	11	the	the	DET
dti-1335	102	12	complex	complex	ADJ
dti-1335	102	13	regulation	regulation	NOUN
dti-1335	102	14	of	of	ADP
dti-1335	102	15	igf	igf	PROPN
dti-1335	102	16	-	-	NOUN
dti-1335	102	17	actions	action	NOUN
dti-1335	102	18	.	.	PUNCT
dti-1335	103	1	the	the	DET
dti-1335	103	2	biological	biological	ADJ
dti-1335	103	3	effects	effect	NOUN
dti-1335	103	4	of	of	ADP
dti-1335	103	5	igf-1	igf-1	NOUN
dti-1335	103	6	on	on	ADP
dti-1335	103	7	target	target	NOUN
dti-1335	103	8	cells	cell	NOUN
dti-1335	103	9	are	be	AUX
dti-1335	103	10	mediated	mediate	VERB
dti-1335	103	11	by	by	ADP
dti-1335	103	12	interactions	interaction	NOUN
dti-1335	103	13	with	with	ADP
dti-1335	103	14	the	the	DET
dti-1335	103	15	type-1	type-1	PROPN
dti-1335	103	16	igf	igf	NOUN
dti-1335	103	17	receptor	receptor	NOUN
dti-1335	103	18	(	(	PUNCT
dti-1335	103	19	leroith	leroith	NOUN
dti-1335	103	20	et	et	PROPN
dti-1335	103	21	al	al	PROPN
dti-1335	103	22	.	.	PROPN
dti-1335	103	23	1995	1995	NUM
dti-1335	103	24	)	)	PUNCT
dti-1335	103	25	.	.	PUNCT
dti-1335	104	1	however	however	ADV
dti-1335	104	2	,	,	PUNCT
dti-1335	104	3	six	six	NUM
dti-1335	104	4	igfbps	igfbps	NOUN
dti-1335	104	5	govern	govern	VERB
dti-1335	104	6	this	this	DET
dti-1335	104	7	interaction	interaction	NOUN
dti-1335	104	8	(	(	PUNCT
dti-1335	104	9	clemmons	clemmon	NOUN
dti-1335	104	10	,	,	PUNCT
dti-1335	104	11	1997	1997	NUM
dti-1335	104	12	;	;	PUNCT
dti-1335	104	13	spagnoli	spagnoli	NOUN
dti-1335	104	14	and	and	CCONJ
dti-1335	104	15	rosenfeld	rosenfeld	PROPN
dti-1335	104	16	,	,	PUNCT
dti-1335	104	17	1997	1997	NUM
dti-1335	104	18	)	)	PUNCT
dti-1335	104	19	.	.	PUNCT
dti-1335	105	1	all	all	DET
dti-1335	105	2	six	six	NUM
dti-1335	105	3	igfbps	igfbps	NOUN
dti-1335	105	4	may	may	AUX
dti-1335	105	5	inhibit	inhibit	VERB
dti-1335	105	6	igf-1	igf-1	PART
dti-1335	105	7	actions	action	NOUN
dti-1335	105	8	by	by	ADP
dti-1335	105	9	sequestering	sequester	VERB
dti-1335	105	10	igf-1	igf-1	NOUN
dti-1335	105	11	,	,	PUNCT
dti-1335	105	12	thereby	thereby	ADV
dti-1335	105	13	preventing	prevent	VERB
dti-1335	105	14	the	the	DET
dti-1335	105	15	interaction	interaction	NOUN
dti-1335	105	16	of	of	ADP
dti-1335	105	17	igf-1	igf-1	NOUN
dti-1335	105	18	to	to	ADP
dti-1335	105	19	its	its	PRON
dti-1335	105	20	receptor	receptor	NOUN
dti-1335	105	21	.	.	PUNCT
dti-1335	106	1	we	we	PRON
dti-1335	106	2	have	have	AUX
dti-1335	106	3	found	find	VERB
dti-1335	106	4	that	that	SCONJ
dti-1335	106	5	igfbp-1	igfbp-1	PROPN
dti-1335	106	6	and	and	CCONJ
dti-1335	106	7	igfbp-6	igfbp-6	NOUN
dti-1335	106	8	were	be	AUX
dti-1335	106	9	upregulated	upregulate	VERB
dti-1335	106	10	on	on	ADP
dti-1335	106	11	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	106	12	in	in	ADP
dti-1335	106	13	the	the	DET
dti-1335	106	14	periplaque	periplaque	ADJ
dti-1335	106	15	white	white	ADJ
dti-1335	106	16	matter	matter	NOUN
dti-1335	106	17	in	in	ADP
dti-1335	106	18	ms	ms	ADJ
dti-1335	106	19	lesions	lesion	NOUN
dti-1335	106	20	(	(	PUNCT
dti-1335	106	21	unpublished	unpublished	ADJ
dti-1335	106	22	results	result	NOUN
dti-1335	106	23	)	)	PUNCT
dti-1335	106	24	.	.	PUNCT
dti-1335	107	1	furthermore	furthermore	ADV
dti-1335	107	2	,	,	PUNCT
dti-1335	107	3	it	it	PRON
dti-1335	107	4	has	have	AUX
dti-1335	107	5	been	be	AUX
dti-1335	107	6	demonstrated	demonstrate	VERB
dti-1335	107	7	that	that	SCONJ
dti-1335	107	8	these	these	DET
dti-1335	107	9	igfbps	igfbps	NOUN
dti-1335	107	10	bind	bind	VERB
dti-1335	107	11	igf-1	igf-1	NOUN
dti-1335	107	12	with	with	ADP
dti-1335	107	13	high	high	ADJ
dti-1335	107	14	affi	affi	PROPN
dti-1335	107	15	nity	nity	NOUN
dti-1335	107	16	,	,	PUNCT
dti-1335	107	17	and	and	CCONJ
dti-1335	107	18	inhibit	inhibit	VERB
dti-1335	107	19	igf-1	igf-1	ADV
dti-1335	107	20	induced	induce	VERB
dti-1335	107	21	survival	survival	NOUN
dti-1335	107	22	and	and	CCONJ
dti-1335	107	23	myelin	myelin	NOUN
dti-1335	107	24	production	production	NOUN
dti-1335	107	25	of	of	ADP
dti-1335	107	26	primary	primary	ADJ
dti-1335	107	27	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	107	28	(	(	PUNCT
dti-1335	107	29	kühl	kühl	NOUN
dti-1335	107	30	et	et	PROPN
dti-1335	107	31	al	al	PROPN
dti-1335	107	32	.	.	PROPN
dti-1335	107	33	2002	2002	NUM
dti-1335	107	34	,	,	PUNCT
dti-1335	107	35	2003	2003	NUM
dti-1335	107	36	)	)	PUNCT
dti-1335	107	37	.	.	PUNCT
dti-1335	108	1	these	these	DET
dti-1335	108	2	results	result	NOUN
dti-1335	108	3	suggest	suggest	VERB
dti-1335	108	4	that	that	SCONJ
dti-1335	108	5	the	the	DET
dti-1335	108	6	up	up	NOUN
dti-1335	108	7	-	-	PUNCT
dti-1335	108	8	regulation	regulation	NOUN
dti-1335	108	9	of	of	ADP
dti-1335	108	10	igfbps	igfbps	NOUN
dti-1335	108	11	lead	lead	NOUN
dti-1335	108	12	to	to	ADP
dti-1335	108	13	a	a	DET
dti-1335	108	14	shortage	shortage	NOUN
dti-1335	108	15	of	of	ADP
dti-1335	108	16	biologically	biologically	ADV
dti-1335	108	17	active	active	ADJ
dti-1335	108	18	(	(	PUNCT
dti-1335	108	19	free	free	ADJ
dti-1335	108	20	)	)	PUNCT
dti-1335	108	21	igf-1	igf-1	NOUN
dti-1335	108	22	in	in	ADP
dti-1335	108	23	the	the	DET
dti-1335	108	24	demyelinated	demyelinated	ADJ
dti-1335	108	25	ms	ms	NOUN
dti-1335	108	26	plaques	plaque	NOUN
dti-1335	108	27	,	,	PUNCT
dti-1335	108	28	contributing	contribute	VERB
dti-1335	108	29	to	to	ADP
dti-1335	108	30	the	the	DET
dti-1335	108	31	lack	lack	NOUN
dti-1335	108	32	of	of	ADP
dti-1335	108	33	(	(	PUNCT
dti-1335	108	34	re)-myelination	re)-myelination	NOUN
dti-1335	108	35	.	.	PUNCT
dti-1335	109	1	however	however	ADV
dti-1335	109	2	,	,	PUNCT
dti-1335	109	3	the	the	DET
dti-1335	109	4	exact	exact	ADJ
dti-1335	109	5	function	function	NOUN
dti-1335	109	6	of	of	ADP
dti-1335	109	7	igfbp-1	igfbp-1	NUM
dti-1335	109	8	and	and	CCONJ
dti-1335	109	9	igfbp-6	igfbp-6	NUM
dti-1335	109	10	41	41	NUM
dti-1335	109	11	targeting	target	VERB
dti-1335	109	12	insulin	insulin	NOUN
dti-1335	109	13	-	-	PUNCT
dti-1335	109	14	like	like	ADJ
dti-1335	109	15	growth	growth	NOUN
dti-1335	109	16	factor-1	factor-1	NUM
dti-1335	109	17	drug	drug	NOUN
dti-1335	109	18	target	target	NOUN
dti-1335	109	19	insights	insight	NOUN
dti-1335	109	20	2008:3	2008:3	NUM
dti-1335	109	21	in	in	ADP
dti-1335	109	22	physiological	physiological	ADJ
dti-1335	109	23	and	and	CCONJ
dti-1335	109	24	pathological	pathological	ADJ
dti-1335	109	25	situations	situation	NOUN
dti-1335	109	26	is	be	AUX
dti-1335	109	27	yet	yet	ADV
dti-1335	109	28	unknown	unknown	ADJ
dti-1335	109	29	.	.	PUNCT
dti-1335	110	1	igf-1	igf-1	PRON
dti-1335	110	2	analogues	analogue	NOUN
dti-1335	110	3	that	that	PRON
dti-1335	110	4	display	display	VERB
dti-1335	110	5	low	low	ADJ
dti-1335	110	6	affi	affi	PROPN
dti-1335	110	7	nity	nity	NOUN
dti-1335	110	8	for	for	ADP
dti-1335	110	9	igfbps	igfbps	NOUN
dti-1335	110	10	,	,	PUNCT
dti-1335	110	11	and	and	CCONJ
dti-1335	110	12	igf-1	igf-1	ADP
dti-1335	110	13	analogues	analogue	NOUN
dti-1335	110	14	that	that	PRON
dti-1335	110	15	display	display	VERB
dti-1335	110	16	high	high	ADJ
dti-1335	110	17	affi	affi	PROPN
dti-1335	110	18	nity	nity	NOUN
dti-1335	110	19	for	for	ADP
dti-1335	110	20	igfbps	igfbps	NOUN
dti-1335	110	21	,	,	PUNCT
dti-1335	110	22	which	which	PRON
dti-1335	110	23	are	be	AUX
dti-1335	110	24	able	able	ADJ
dti-1335	110	25	to	to	PART
dti-1335	110	26	displace	displace	VERB
dti-1335	110	27	endogenous	endogenous	ADJ
dti-1335	110	28	igf-1	igf-1	ADV
dti-1335	110	29	and	and	CCONJ
dti-1335	110	30	or	or	CCONJ
dti-1335	110	31	igf-2	igf-2	ADV
dti-1335	110	32	from	from	ADP
dti-1335	110	33	igfbps	igfbps	NOUN
dti-1335	110	34	,	,	PUNCT
dti-1335	110	35	may	may	AUX
dti-1335	110	36	be	be	AUX
dti-1335	110	37	suitable	suitable	ADJ
dti-1335	110	38	candidates	candidate	NOUN
dti-1335	110	39	for	for	ADP
dti-1335	110	40	stimulating	stimulate	VERB
dti-1335	110	41	(	(	PUNCT
dti-1335	110	42	re	re	NOUN
dti-1335	110	43	)	)	PUNCT
dti-1335	110	44	myelination	myelination	NOUN
dti-1335	110	45	in	in	ADP
dti-1335	110	46	ms	ms	PROPN
dti-1335	110	47	(	(	PUNCT
dti-1335	110	48	fig	fig	NOUN
dti-1335	110	49	.	.	PUNCT
dti-1335	110	50	2	2	NUM
dti-1335	110	51	)	)	PUNCT
dti-1335	110	52	.	.	PUNCT
dti-1335	111	1	des(1	des(1	PROPN
dti-1335	111	2	-	-	PUNCT
dti-1335	111	3	3	3	NUM
dti-1335	111	4	)	)	PUNCT
dti-1335	111	5	igf-1	igf-1	NOUN
dti-1335	111	6	is	be	AUX
dti-1335	111	7	a	a	DET
dti-1335	111	8	truncated	truncated	ADJ
dti-1335	111	9	form	form	NOUN
dti-1335	111	10	of	of	ADP
dti-1335	111	11	igf-1	igf-1	NOUN
dti-1335	111	12	lacking	lack	VERB
dti-1335	111	13	the	the	DET
dti-1335	111	14	tripeptide	tripeptide	ADJ
dti-1335	111	15	glycine	glycine	NOUN
dti-1335	111	16	-	-	PUNCT
dti-1335	111	17	proline	proline	NOUN
dti-1335	111	18	-	-	PUNCT
dti-1335	111	19	glutamate	glutamate	NOUN
dti-1335	111	20	(	(	PUNCT
dti-1335	111	21	gpe	gpe	NOUN
dti-1335	111	22	)	)	PUNCT
dti-1335	111	23	at	at	ADP
dti-1335	111	24	the	the	DET
dti-1335	111	25	aminoterminus	aminoterminus	NOUN
dti-1335	111	26	of	of	ADP
dti-1335	111	27	the	the	DET
dti-1335	111	28	full	full	ADJ
dti-1335	111	29	-	-	PUNCT
dti-1335	111	30	length	length	NOUN
dti-1335	111	31	form	form	NOUN
dti-1335	111	32	(	(	PUNCT
dti-1335	111	33	sara	sara	PROPN
dti-1335	111	34	et	et	PROPN
dti-1335	111	35	al	al	PROPN
dti-1335	111	36	.	.	PROPN
dti-1335	111	37	1986	1986	NUM
dti-1335	111	38	)	)	PUNCT
dti-1335	111	39	.	.	PUNCT
dti-1335	112	1	the	the	DET
dti-1335	112	2	biological	biological	ADJ
dti-1335	112	3	potency	potency	NOUN
dti-1335	112	4	of	of	ADP
dti-1335	112	5	this	this	DET
dti-1335	112	6	analogue	analogue	NOUN
dti-1335	112	7	is	be	AUX
dti-1335	112	8	signifi	signifi	NOUN
dti-1335	112	9	cantly	cantly	ADV
dti-1335	112	10	higher	high	ADJ
dti-1335	112	11	than	than	ADP
dti-1335	112	12	that	that	PRON
dti-1335	112	13	of	of	ADP
dti-1335	112	14	the	the	DET
dti-1335	112	15	full	full	ADJ
dti-1335	112	16	-	-	PUNCT
dti-1335	112	17	length	length	NOUN
dti-1335	112	18	form	form	NOUN
dti-1335	112	19	and	and	CCONJ
dti-1335	112	20	is	be	AUX
dti-1335	112	21	explained	explain	VERB
dti-1335	112	22	by	by	ADP
dti-1335	112	23	its	its	PRON
dti-1335	112	24	reduced	reduce	VERB
dti-1335	112	25	affi	affi	PROPN
dti-1335	112	26	nity	nity	NOUN
dti-1335	112	27	for	for	ADP
dti-1335	112	28	igfbps	igfbps	NOUN
dti-1335	112	29	.	.	PUNCT
dti-1335	113	1	igf-1	igf-1	NOUN
dti-1335	113	2	analogues	analogue	NOUN
dti-1335	113	3	that	that	PRON
dti-1335	113	4	display	display	VERB
dti-1335	113	5	high	high	ADJ
dti-1335	113	6	affi	affi	PROPN
dti-1335	113	7	nity	nity	NOUN
dti-1335	113	8	for	for	ADP
dti-1335	113	9	igfbps	igfbps	NOUN
dti-1335	113	10	,	,	PUNCT
dti-1335	113	11	which	which	PRON
dti-1335	113	12	can	can	AUX
dti-1335	113	13	therefore	therefore	ADV
dti-1335	113	14	displace	displace	VERB
dti-1335	113	15	endogenous	endogenous	ADJ
dti-1335	113	16	figure	figure	NOUN
dti-1335	113	17	2	2	NUM
dti-1335	113	18	.	.	PUNCT
dti-1335	113	19	a	a	DET
dti-1335	113	20	schematic	schematic	ADJ
dti-1335	113	21	overview	overview	NOUN
dti-1335	113	22	:	:	PUNCT
dti-1335	113	23	astrocytes	astrocyte	NOUN
dti-1335	113	24	regulate	regulate	VERB
dti-1335	113	25	their	their	PRON
dti-1335	113	26	own	own	ADJ
dti-1335	113	27	cellular	cellular	ADJ
dti-1335	113	28	action	action	NOUN
dti-1335	113	29	through	through	ADP
dti-1335	113	30	igf-1	igf-1	PRON
dti-1335	113	31	,	,	PUNCT
dti-1335	113	32	and	and	CCONJ
dti-1335	113	33	astrocytic	astrocytic	ADJ
dti-1335	113	34	igf-1	igf-1	PRON
dti-1335	113	35	has	have	VERB
dti-1335	113	36	no	no	DET
dti-1335	113	37	effect	effect	NOUN
dti-1335	113	38	on	on	ADP
dti-1335	113	39	(	(	PUNCT
dti-1335	113	40	pre)myelinating	pre)myelinate	VERB
dti-1335	113	41	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	113	42	in	in	ADP
dti-1335	113	43	ms	ms	PROPN
dti-1335	113	44	.	.	PROPN
dti-1335	113	45	astrocytes	astrocyte	NOUN
dti-1335	113	46	become	become	VERB
dti-1335	113	47	astrogliotic	astrogliotic	ADJ
dti-1335	113	48	forming	form	VERB
dti-1335	113	49	the	the	DET
dti-1335	113	50	tissue	tissue	NOUN
dti-1335	113	51	scar	scar	NOUN
dti-1335	113	52	in	in	ADP
dti-1335	113	53	ms	ms	ADJ
dti-1335	113	54	lesions	lesion	NOUN
dti-1335	113	55	and	and	CCONJ
dti-1335	113	56	preventing	prevent	VERB
dti-1335	113	57	remyelination	remyelination	NOUN
dti-1335	113	58	by	by	ADP
dti-1335	113	59	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	113	60	(	(	PUNCT
dti-1335	113	61	a	a	NOUN
dti-1335	113	62	)	)	PUNCT
dti-1335	113	63	.	.	PUNCT
dti-1335	114	1	through	through	ADP
dti-1335	114	2	intranasal	intranasal	ADJ
dti-1335	114	3	application	application	NOUN
dti-1335	114	4	of	of	ADP
dti-1335	114	5	igf-1	igf-1	NOUN
dti-1335	114	6	analogues	analogue	NOUN
dti-1335	114	7	and	and	CCONJ
dti-1335	114	8	or	or	CCONJ
dti-1335	114	9	igfbp	igfbp	ADV
dti-1335	114	10	ligand	ligand	ADJ
dti-1335	114	11	inhibitors	inhibitor	NOUN
dti-1335	114	12	,	,	PUNCT
dti-1335	114	13	igf-1	igf-1	PUNCT
dti-1335	114	14	is	be	AUX
dti-1335	114	15	released	release	VERB
dti-1335	114	16	from	from	ADP
dti-1335	114	17	igfbps	igfbps	NOUN
dti-1335	114	18	which	which	PRON
dti-1335	114	19	are	be	AUX
dti-1335	114	20	present	present	ADJ
dti-1335	114	21	on	on	ADP
dti-1335	114	22	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	114	23	and	and	CCONJ
dti-1335	114	24	igf-1	igf-1	ADV
dti-1335	114	25	become	become	VERB
dti-1335	114	26	available	available	ADJ
dti-1335	114	27	to	to	ADP
dti-1335	114	28	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	114	29	,	,	PUNCT
dti-1335	114	30	resulting	result	VERB
dti-1335	114	31	in	in	ADP
dti-1335	114	32	remyelination	remyelination	NOUN
dti-1335	114	33	(	(	PUNCT
dti-1335	114	34	b	b	NOUN
dti-1335	114	35	)	)	PUNCT
dti-1335	114	36	.	.	PUNCT
dti-1335	115	1	42	42	NUM
dti-1335	115	2	wilczak	wilczak	NOUN
dti-1335	115	3	et	et	PROPN
dti-1335	115	4	al	al	PROPN
dti-1335	115	5	drug	drug	PROPN
dti-1335	115	6	target	target	NOUN
dti-1335	115	7	insights	insight	NOUN
dti-1335	115	8	2008:3	2008:3	NUM
dti-1335	115	9	igf-1	igf-1	NOUN
dti-1335	115	10	from	from	ADP
dti-1335	115	11	igfbps	igfbps	NOUN
dti-1335	115	12	might	might	AUX
dti-1335	115	13	also	also	ADV
dti-1335	115	14	be	be	AUX
dti-1335	115	15	considered	consider	VERB
dti-1335	115	16	.	.	PUNCT
dti-1335	116	1	this	this	DET
dti-1335	116	2	approach	approach	NOUN
dti-1335	116	3	has	have	AUX
dti-1335	116	4	already	already	ADV
dti-1335	116	5	been	be	AUX
dti-1335	116	6	studied	study	VERB
dti-1335	116	7	in	in	ADP
dti-1335	116	8	rats	rat	NOUN
dti-1335	116	9	with	with	ADP
dti-1335	116	10	focal	focal	ADJ
dti-1335	116	11	cerebral	cerebral	ADJ
dti-1335	116	12	ischemia	ischemia	NOUN
dti-1335	116	13	.	.	PUNCT
dti-1335	117	1	in	in	ADP
dti-1335	117	2	this	this	DET
dti-1335	117	3	model	model	NOUN
dti-1335	117	4	,	,	PUNCT
dti-1335	117	5	the	the	DET
dti-1335	117	6	intracerebroventricular	intracerebroventricular	ADJ
dti-1335	117	7	administration	administration	NOUN
dti-1335	117	8	of	of	ADP
dti-1335	117	9	the	the	DET
dti-1335	117	10	igf-1	igf-1	NOUN
dti-1335	117	11	analogue	analogue	NOUN
dti-1335	117	12	[	[	X
dti-1335	117	13	(	(	PUNCT
dti-1335	117	14	leu24,59,60	leu24,59,60	ADJ
dti-1335	117	15	,	,	PUNCT
dti-1335	117	16	ala31	ala31	PROPN
dti-1335	117	17	)	)	PUNCT
dti-1335	117	18	higf-1	higf-1	PROPN
dti-1335	117	19	]	]	PUNCT
dti-1335	117	20	with	with	ADP
dti-1335	117	21	high	high	ADJ
dti-1335	117	22	affi	affi	PROPN
dti-1335	117	23	nity	nity	NOUN
dti-1335	117	24	to	to	ADP
dti-1335	117	25	igfbps	igfbps	NOUN
dti-1335	117	26	and	and	CCONJ
dti-1335	117	27	no	no	DET
dti-1335	117	28	affi	affi	PROPN
dti-1335	117	29	nity	nity	NOUN
dti-1335	117	30	to	to	ADP
dti-1335	117	31	type-1	type-1	PROPN
dti-1335	117	32	igf	igf	NOUN
dti-1335	117	33	receptors	receptor	NOUN
dti-1335	117	34	,	,	PUNCT
dti-1335	117	35	increased	increase	VERB
dti-1335	117	36	levels	level	NOUN
dti-1335	117	37	of	of	ADP
dti-1335	117	38	biologically	biologically	ADV
dti-1335	117	39	active	active	ADJ
dti-1335	117	40	igf-1	igf-1	NOUN
dti-1335	117	41	and	and	CCONJ
dti-1335	117	42	provided	provide	VERB
dti-1335	117	43	potent	potent	ADJ
dti-1335	117	44	neuroprotection	neuroprotection	NOUN
dti-1335	117	45	(	(	PUNCT
dti-1335	117	46	loddick	loddick	PROPN
dti-1335	117	47	et	et	PROPN
dti-1335	117	48	al	al	PROPN
dti-1335	117	49	.	.	PROPN
dti-1335	117	50	1998	1998	NUM
dti-1335	117	51	)	)	PUNCT
dti-1335	117	52	.	.	PUNCT
dti-1335	118	1	a	a	DET
dti-1335	118	2	third	third	ADJ
dti-1335	118	3	obstacle	obstacle	NOUN
dti-1335	118	4	lies	lie	VERB
dti-1335	118	5	in	in	ADP
dti-1335	118	6	the	the	DET
dti-1335	118	7	targeting	targeting	NOUN
dti-1335	118	8	of	of	ADP
dti-1335	118	9	igf-1	igf-1	NOUN
dti-1335	118	10	signaling	signal	VERB
dti-1335	118	11	to	to	ADP
dti-1335	118	12	the	the	DET
dti-1335	118	13	myelin	myelin	NOUN
dti-1335	118	14	producing	produce	VERB
dti-1335	118	15	cells	cell	NOUN
dti-1335	118	16	:	:	PUNCT
dti-1335	118	17	the	the	DET
dti-1335	118	18	oligodendrocyte	oligodendrocyte	NOUN
dti-1335	118	19	.	.	PUNCT
dti-1335	119	1	such	such	DET
dti-1335	119	2	a	a	DET
dti-1335	119	3	targeting	targeting	NOUN
dti-1335	119	4	is	be	AUX
dti-1335	119	5	complicated	complicate	VERB
dti-1335	119	6	by	by	ADP
dti-1335	119	7	the	the	DET
dti-1335	119	8	high	high	ADJ
dti-1335	119	9	expression	expression	NOUN
dti-1335	119	10	of	of	ADP
dti-1335	119	11	type-1	type-1	PROPN
dti-1335	119	12	igf	igf	NOUN
dti-1335	119	13	receptors	receptor	NOUN
dti-1335	119	14	on	on	ADP
dti-1335	119	15	other	other	ADJ
dti-1335	119	16	cells	cell	NOUN
dti-1335	119	17	in	in	ADP
dti-1335	119	18	the	the	DET
dti-1335	119	19	cns	cns	NOUN
dti-1335	119	20	.	.	PUNCT
dti-1335	120	1	we	we	PRON
dti-1335	120	2	have	have	AUX
dti-1335	120	3	demonstrated	demonstrate	VERB
dti-1335	120	4	that	that	SCONJ
dti-1335	120	5	type-1	type-1	PROPN
dti-1335	120	6	igf	igf	NOUN
dti-1335	120	7	receptors	receptor	NOUN
dti-1335	120	8	were	be	AUX
dti-1335	120	9	present	present	ADJ
dti-1335	120	10	on	on	ADP
dti-1335	120	11	neurons	neuron	NOUN
dti-1335	120	12	and	and	CCONJ
dti-1335	120	13	other	other	ADJ
dti-1335	120	14	glial	glial	ADJ
dti-1335	120	15	cells	cell	NOUN
dti-1335	120	16	,	,	PUNCT
dti-1335	120	17	including	include	VERB
dti-1335	120	18	microglia	microglia	NOUN
dti-1335	120	19	and	and	CCONJ
dti-1335	120	20	astrocytes	astrocyte	NOUN
dti-1335	120	21	(	(	PUNCT
dti-1335	120	22	de	de	X
dti-1335	120	23	keyser	keyser	PROPN
dti-1335	120	24	et	et	PROPN
dti-1335	120	25	al	al	PROPN
dti-1335	120	26	.	.	PROPN
dti-1335	120	27	1994a	1994a	NUM
dti-1335	120	28	;	;	PUNCT
dti-1335	120	29	wilczak	wilczak	NOUN
dti-1335	120	30	and	and	CCONJ
dti-1335	120	31	de	de	X
dti-1335	120	32	keyser	keyser	PROPN
dti-1335	120	33	,	,	PUNCT
dti-1335	120	34	1997	1997	NUM
dti-1335	120	35	)	)	PUNCT
dti-1335	120	36	.	.	PUNCT
dti-1335	121	1	this	this	PRON
dti-1335	121	2	may	may	AUX
dti-1335	121	3	have	have	VERB
dti-1335	121	4	important	important	ADJ
dti-1335	121	5	implications	implication	NOUN
dti-1335	121	6	for	for	ADP
dti-1335	121	7	the	the	DET
dti-1335	121	8	clinical	clinical	ADJ
dti-1335	121	9	use	use	NOUN
dti-1335	121	10	of	of	ADP
dti-1335	121	11	igf-1	igf-1	NOUN
dti-1335	121	12	in	in	ADP
dti-1335	121	13	ms	ms	PROPN
dti-1335	121	14	.	.	PROPN
dti-1335	121	15	chronic	chronic	ADJ
dti-1335	121	16	plaques	plaque	NOUN
dti-1335	121	17	of	of	ADP
dti-1335	121	18	ms	ms	NOUN
dti-1335	121	19	contain	contain	VERB
dti-1335	121	20	a	a	DET
dti-1335	121	21	dense	dense	ADJ
dti-1335	121	22	network	network	NOUN
dti-1335	121	23	of	of	ADP
dti-1335	121	24	astrocytes	astrocyte	NOUN
dti-1335	121	25	,	,	PUNCT
dti-1335	121	26	which	which	PRON
dti-1335	121	27	are	be	AUX
dti-1335	121	28	responsible	responsible	ADJ
dti-1335	121	29	for	for	ADP
dti-1335	121	30	the	the	DET
dti-1335	121	31	characteristic	characteristic	ADJ
dti-1335	121	32	astrogliotic	astrogliotic	ADJ
dti-1335	121	33	plaque	plaque	NOUN
dti-1335	121	34	.	.	PUNCT
dti-1335	122	1	in	in	ADP
dti-1335	122	2	vitro	vitro	X
dti-1335	122	3	studies	study	NOUN
dti-1335	122	4	have	have	AUX
dti-1335	122	5	shown	show	VERB
dti-1335	122	6	that	that	SCONJ
dti-1335	122	7	igf-1	igf-1	NOUN
dti-1335	122	8	enhances	enhance	VERB
dti-1335	122	9	the	the	DET
dti-1335	122	10	proliferation	proliferation	NOUN
dti-1335	122	11	of	of	ADP
dti-1335	122	12	astrocytes	astrocyte	NOUN
dti-1335	122	13	(	(	PUNCT
dti-1335	122	14	chesik	chesik	NOUN
dti-1335	122	15	et	et	PROPN
dti-1335	122	16	al	al	PROPN
dti-1335	122	17	.	.	PROPN
dti-1335	122	18	2004	2004	NUM
dti-1335	122	19	;	;	PUNCT
dti-1335	122	20	tranque	tranque	NOUN
dti-1335	122	21	et	et	PROPN
dti-1335	122	22	al	al	PROPN
dti-1335	122	23	.	.	PROPN
dti-1335	122	24	1992	1992	NUM
dti-1335	122	25	)	)	PUNCT
dti-1335	122	26	.	.	PUNCT
dti-1335	123	1	as	as	SCONJ
dti-1335	123	2	acute	acute	ADJ
dti-1335	123	3	ms	ms	PROPN
dti-1335	123	4	lesions	lesion	NOUN
dti-1335	123	5	are	be	AUX
dti-1335	123	6	rapidly	rapidly	ADV
dti-1335	123	7	invaded	invade	VERB
dti-1335	123	8	by	by	ADP
dti-1335	123	9	reactive	reactive	ADJ
dti-1335	123	10	astrocytes	astrocyte	NOUN
dti-1335	123	11	,	,	PUNCT
dti-1335	123	12	enhancing	enhance	VERB
dti-1335	123	13	the	the	DET
dti-1335	123	14	levels	level	NOUN
dti-1335	123	15	of	of	ADP
dti-1335	123	16	igf-1	igf-1	NOUN
dti-1335	123	17	in	in	ADP
dti-1335	123	18	ms	ms	ADJ
dti-1335	123	19	lesions	lesion	NOUN
dti-1335	123	20	may	may	AUX
dti-1335	123	21	not	not	PART
dti-1335	123	22	only	only	ADV
dti-1335	123	23	protect	protect	VERB
dti-1335	123	24	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	123	25	and	and	CCONJ
dti-1335	123	26	stimulate	stimulate	VERB
dti-1335	123	27	remyelination	remyelination	NOUN
dti-1335	123	28	but	but	CCONJ
dti-1335	123	29	also	also	ADV
dti-1335	123	30	enhance	enhance	VERB
dti-1335	123	31	the	the	DET
dti-1335	123	32	astrogliosis	astrogliosis	NOUN
dti-1335	123	33	that	that	PRON
dti-1335	123	34	creates	create	VERB
dti-1335	123	35	a	a	DET
dti-1335	123	36	glial	glial	ADJ
dti-1335	123	37	scar	scar	NOUN
dti-1335	123	38	,	,	PUNCT
dti-1335	123	39	limiting	limit	VERB
dti-1335	123	40	remyelinating	remyelinate	VERB
dti-1335	123	41	processes	process	NOUN
dti-1335	123	42	.	.	PUNCT
dti-1335	124	1	for	for	ADP
dti-1335	124	2	these	these	DET
dti-1335	124	3	reasons	reason	NOUN
dti-1335	124	4	,	,	PUNCT
dti-1335	124	5	targeting	target	VERB
dti-1335	124	6	igf-1	igf-1	NOUN
dti-1335	124	7	effects	effect	NOUN
dti-1335	124	8	to	to	ADP
dti-1335	124	9	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	124	10	is	be	AUX
dti-1335	124	11	crucial	crucial	ADJ
dti-1335	124	12	.	.	PUNCT
dti-1335	125	1	a	a	DET
dti-1335	125	2	feasible	feasible	ADJ
dti-1335	125	3	approach	approach	NOUN
dti-1335	125	4	for	for	ADP
dti-1335	125	5	targeting	target	VERB
dti-1335	125	6	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	125	7	consists	consist	VERB
dti-1335	125	8	of	of	ADP
dti-1335	125	9	intervening	intervene	VERB
dti-1335	125	10	in	in	ADP
dti-1335	125	11	igf-1	igf-1	PRON
dti-1335	125	12	regulation	regulation	NOUN
dti-1335	125	13	by	by	ADP
dti-1335	125	14	igfbps	igfbps	NOUN
dti-1335	125	15	.	.	PUNCT
dti-1335	126	1	in	in	ADP
dti-1335	126	2	ms	ms	ADJ
dti-1335	126	3	lesions	lesion	NOUN
dti-1335	126	4	,	,	PUNCT
dti-1335	126	5	we	we	PRON
dti-1335	126	6	have	have	AUX
dti-1335	126	7	shown	show	VERB
dti-1335	126	8	a	a	DET
dti-1335	126	9	unique	unique	ADJ
dti-1335	126	10	distribution	distribution	NOUN
dti-1335	126	11	of	of	ADP
dti-1335	126	12	igfbps	igfbps	NOUN
dti-1335	126	13	expression	expression	NOUN
dti-1335	126	14	on	on	ADP
dti-1335	126	15	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	126	16	and	and	CCONJ
dti-1335	126	17	astrocytes	astrocyte	NOUN
dti-1335	126	18	.	.	PUNCT
dti-1335	127	1	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	127	2	in	in	ADP
dti-1335	127	3	demyelinated	demyelinated	ADJ
dti-1335	127	4	ms	ms	PROPN
dti-1335	127	5	plaques	plaque	NOUN
dti-1335	127	6	display	display	VERB
dti-1335	127	7	an	an	DET
dti-1335	127	8	upregulation	upregulation	NOUN
dti-1335	127	9	of	of	ADP
dti-1335	127	10	igfbp-1	igfbp-1	NUM
dti-1335	127	11	and	and	CCONJ
dti-1335	127	12	igfbp-6	igfbp-6	NOUN
dti-1335	127	13	,	,	PUNCT
dti-1335	127	14	whereas	whereas	SCONJ
dti-1335	127	15	astrocytes	astrocyte	NOUN
dti-1335	127	16	show	show	VERB
dti-1335	127	17	increased	increase	VERB
dti-1335	127	18	expression	expression	NOUN
dti-1335	127	19	of	of	ADP
dti-1335	127	20	igfbp-2	igfbp-2	PROPN
dti-1335	127	21	and	and	CCONJ
dti-1335	127	22	igfbp-4	igfbp-4	NUM
dti-1335	127	23	(	(	PUNCT
dti-1335	127	24	chesik	chesik	NOUN
dti-1335	127	25	et	et	PROPN
dti-1335	127	26	al	al	PROPN
dti-1335	127	27	.	.	PROPN
dti-1335	127	28	2006	2006	NUM
dti-1335	127	29	)	)	PUNCT
dti-1335	127	30	.	.	PUNCT
dti-1335	128	1	an	an	DET
dti-1335	128	2	interesting	interesting	ADJ
dti-1335	128	3	prospect	prospect	NOUN
dti-1335	128	4	is	be	AUX
dti-1335	128	5	the	the	DET
dti-1335	128	6	use	use	NOUN
dti-1335	128	7	of	of	ADP
dti-1335	128	8	non	non	ADJ
dti-1335	128	9	-	-	ADJ
dti-1335	128	10	peptide	peptide	ADJ
dti-1335	128	11	small	small	ADJ
dti-1335	128	12	molecules	molecule	NOUN
dti-1335	128	13	that	that	PRON
dti-1335	128	14	act	act	VERB
dti-1335	128	15	as	as	SCONJ
dti-1335	128	16	specifi	specifi	PROPN
dti-1335	128	17	c	c	PROPN
dti-1335	128	18	igfbp	igfbp	ADV
dti-1335	128	19	ligand	ligand	VERB
dti-1335	128	20	inhibitors	inhibitor	NOUN
dti-1335	128	21	and	and	CCONJ
dti-1335	128	22	prevent	prevent	VERB
dti-1335	128	23	binding	binding	NOUN
dti-1335	128	24	of	of	ADP
dti-1335	128	25	igf-1	igf-1	PRON
dti-1335	128	26	to	to	ADP
dti-1335	128	27	specifi	specifi	PROPN
dti-1335	128	28	c	c	PROPN
dti-1335	128	29	igfbps	igfbps	PROPN
dti-1335	128	30	(	(	PUNCT
dti-1335	128	31	chen	chen	PROPN
dti-1335	128	32	et	et	PROPN
dti-1335	128	33	al	al	PROPN
dti-1335	128	34	.	.	PROPN
dti-1335	128	35	2001	2001	NUM
dti-1335	128	36	;	;	PUNCT
dti-1335	128	37	zhu	zhu	PROPN
dti-1335	128	38	et	et	PROPN
dti-1335	128	39	al	al	PROPN
dti-1335	128	40	.	.	PROPN
dti-1335	128	41	2003	2003	NUM
dti-1335	128	42	)	)	PUNCT
dti-1335	128	43	.	.	PUNCT
dti-1335	129	1	this	this	DET
dti-1335	129	2	approach	approach	NOUN
dti-1335	129	3	would	would	AUX
dti-1335	129	4	result	result	VERB
dti-1335	129	5	in	in	ADP
dti-1335	129	6	an	an	DET
dti-1335	129	7	elevation	elevation	NOUN
dti-1335	129	8	of	of	ADP
dti-1335	129	9	biological	biological	ADJ
dti-1335	129	10	active	active	ADJ
dti-1335	129	11	igf-1	igf-1	NOUN
dti-1335	129	12	that	that	PRON
dti-1335	129	13	is	be	AUX
dti-1335	129	14	available	available	ADJ
dti-1335	129	15	in	in	ADP
dti-1335	129	16	the	the	DET
dti-1335	129	17	vicinity	vicinity	NOUN
dti-1335	129	18	of	of	ADP
dti-1335	129	19	olgodendrocytes	olgodendrocyte	NOUN
dti-1335	129	20	.	.	PUNCT
dti-1335	130	1	nbi-31772	nbi-31772	PROPN
dti-1335	130	2	is	be	AUX
dti-1335	130	3	a	a	DET
dti-1335	130	4	recently	recently	ADV
dti-1335	130	5	developed	develop	VERB
dti-1335	130	6	non	non	ADJ
dti-1335	130	7	-	-	ADJ
dti-1335	130	8	peptide	peptide	ADJ
dti-1335	130	9	small	small	ADJ
dti-1335	130	10	molecule	molecule	NOUN
dti-1335	130	11	that	that	PRON
dti-1335	130	12	binds	bind	VERB
dti-1335	130	13	to	to	ADP
dti-1335	130	14	all	all	DET
dti-1335	130	15	six	six	NUM
dti-1335	130	16	known	know	VERB
dti-1335	130	17	igfbps	igfbps	NOUN
dti-1335	130	18	and	and	CCONJ
dti-1335	130	19	displaces	displace	VERB
dti-1335	130	20	biologically	biologically	ADV
dti-1335	130	21	active	active	ADJ
dti-1335	130	22	igf-1	igf-1	ADV
dti-1335	130	23	from	from	ADP
dti-1335	130	24	all	all	DET
dti-1335	130	25	six	six	NUM
dti-1335	130	26	binding	bind	VERB
dti-1335	130	27	proteins	protein	NOUN
dti-1335	130	28	(	(	PUNCT
dti-1335	130	29	liu	liu	PROPN
dti-1335	130	30	et	et	PROPN
dti-1335	130	31	al	al	PROPN
dti-1335	130	32	.	.	PUNCT
dti-1335	131	1	2001).the	2001).the	DET
dti-1335	131	2	neuroprotective	neuroprotective	ADJ
dti-1335	131	3	effects	effect	NOUN
dti-1335	131	4	of	of	ADP
dti-1335	131	5	nbi31772	nbi31772	NOUN
dti-1335	131	6	has	have	AUX
dti-1335	131	7	been	be	AUX
dti-1335	131	8	studied	study	VERB
dti-1335	131	9	in	in	ADP
dti-1335	131	10	experimental	experimental	ADJ
dti-1335	131	11	models	model	NOUN
dti-1335	131	12	of	of	ADP
dti-1335	131	13	cerebral	cerebral	ADJ
dti-1335	131	14	ischemia	ischemia	NOUN
dti-1335	131	15	.	.	PUNCT
dti-1335	132	1	this	this	DET
dti-1335	132	2	study	study	NOUN
dti-1335	132	3	has	have	AUX
dti-1335	132	4	demonstrated	demonstrate	VERB
dti-1335	132	5	that	that	SCONJ
dti-1335	132	6	intracerebroventricular	intracerebroventricular	ADJ
dti-1335	132	7	administration	administration	NOUN
dti-1335	132	8	of	of	ADP
dti-1335	132	9	nbi31772	nbi31772	NOUN
dti-1335	132	10	signifi	signifi	PROPN
dti-1335	132	11	cantly	cantly	ADV
dti-1335	132	12	reduced	reduce	VERB
dti-1335	132	13	ischemic	ischemic	ADJ
dti-1335	132	14	brain	brain	NOUN
dti-1335	132	15	damage	damage	NOUN
dti-1335	132	16	and	and	CCONJ
dti-1335	132	17	infarct	infarct	NOUN
dti-1335	132	18	size	size	NOUN
dti-1335	132	19	.	.	PUNCT
dti-1335	133	1	(	(	PUNCT
dti-1335	133	2	mackay	mackay	PROPN
dti-1335	133	3	et	et	PROPN
dti-1335	133	4	al	al	PROPN
dti-1335	133	5	.	.	PROPN
dti-1335	133	6	2003	2003	NUM
dti-1335	133	7	)	)	PUNCT
dti-1335	133	8	.	.	PUNCT
dti-1335	134	1	new	new	ADJ
dti-1335	134	2	potent	potent	ADJ
dti-1335	134	3	ligand	ligand	NOUN
dti-1335	134	4	-	-	PUNCT
dti-1335	134	5	inhibitors	inhibitor	NOUN
dti-1335	134	6	could	could	AUX
dti-1335	134	7	be	be	AUX
dti-1335	134	8	designed	design	VERB
dti-1335	134	9	which	which	PRON
dti-1335	134	10	selectively	selectively	ADV
dti-1335	134	11	bind	bind	VERB
dti-1335	134	12	individual	individual	ADJ
dti-1335	134	13	igfbps	igfbps	NOUN
dti-1335	134	14	in	in	ADP
dti-1335	134	15	order	order	NOUN
dti-1335	134	16	to	to	PART
dti-1335	134	17	enhance	enhance	VERB
dti-1335	134	18	and	and	CCONJ
dti-1335	134	19	target	target	VERB
dti-1335	134	20	bioactive	bioactive	VERB
dti-1335	134	21	igf-1	igf-1	NOUN
dti-1335	134	22	.	.	PUNCT
dti-1335	135	1	another	another	DET
dti-1335	135	2	approach	approach	NOUN
dti-1335	135	3	to	to	PART
dti-1335	135	4	elevate	elevate	VERB
dti-1335	135	5	igf-1	igf-1	NOUN
dti-1335	135	6	levels	level	NOUN
dti-1335	135	7	as	as	ADV
dti-1335	135	8	well	well	ADV
dti-1335	135	9	as	as	ADP
dti-1335	135	10	target	target	VERB
dti-1335	135	11	igf-1	igf-1	NOUN
dti-1335	135	12	into	into	ADP
dti-1335	135	13	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	135	14	is	be	AUX
dti-1335	135	15	altering	alter	VERB
dti-1335	135	16	the	the	DET
dti-1335	135	17	expression	expression	NOUN
dti-1335	135	18	level	level	NOUN
dti-1335	135	19	of	of	ADP
dti-1335	135	20	igfbps	igfbps	NOUN
dti-1335	135	21	on	on	ADP
dti-1335	135	22	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	135	23	and	and	CCONJ
dti-1335	135	24	astrocytes	astrocyte	NOUN
dti-1335	135	25	in	in	ADP
dti-1335	135	26	ms	ms	PROPN
dti-1335	135	27	.	.	PROPN
dti-1335	136	1	igfbp-2	igfbp-2	PROPN
dti-1335	136	2	is	be	AUX
dti-1335	136	3	of	of	ADP
dti-1335	136	4	particular	particular	ADJ
dti-1335	136	5	interest	interest	NOUN
dti-1335	136	6	because	because	SCONJ
dti-1335	136	7	hypertrophic	hypertrophic	ADJ
dti-1335	136	8	astrocytes	astrocyte	NOUN
dti-1335	136	9	in	in	ADP
dti-1335	136	10	ms	ms	ADJ
dti-1335	136	11	lesions	lesion	NOUN
dti-1335	136	12	express	express	VERB
dti-1335	136	13	high	high	ADJ
dti-1335	136	14	levels	level	NOUN
dti-1335	136	15	of	of	ADP
dti-1335	136	16	igfbp-2	igfbp-2	PROPN
dti-1335	136	17	(	(	PUNCT
dti-1335	136	18	chesik	chesik	NOUN
dti-1335	136	19	et	et	PROPN
dti-1335	136	20	al	al	PROPN
dti-1335	136	21	.	.	PROPN
dti-1335	136	22	2006	2006	NUM
dti-1335	136	23	)	)	PUNCT
dti-1335	136	24	.	.	PUNCT
dti-1335	137	1	astrocytes	astrocyte	NOUN
dti-1335	137	2	are	be	AUX
dti-1335	137	3	the	the	DET
dti-1335	137	4	primary	primary	ADJ
dti-1335	137	5	source	source	NOUN
dti-1335	137	6	of	of	ADP
dti-1335	137	7	igf-1	igf-1	NOUN
dti-1335	137	8	in	in	ADP
dti-1335	137	9	damaged	damaged	ADJ
dti-1335	137	10	cns	cns	NOUN
dti-1335	137	11	,	,	PUNCT
dti-1335	137	12	and	and	CCONJ
dti-1335	137	13	it	it	PRON
dti-1335	137	14	has	have	AUX
dti-1335	137	15	been	be	AUX
dti-1335	137	16	suggested	suggest	VERB
dti-1335	137	17	that	that	SCONJ
dti-1335	137	18	this	this	DET
dti-1335	137	19	growth	growth	NOUN
dti-1335	137	20	factor	factor	NOUN
dti-1335	137	21	assists	assist	VERB
dti-1335	137	22	in	in	ADP
dti-1335	137	23	neuronal	neuronal	ADJ
dti-1335	137	24	protection	protection	NOUN
dti-1335	137	25	as	as	ADV
dti-1335	137	26	well	well	ADV
dti-1335	137	27	as	as	ADP
dti-1335	137	28	in	in	ADP
dti-1335	137	29	facilitation	facilitation	NOUN
dti-1335	137	30	of	of	ADP
dti-1335	137	31	myelin	myelin	NOUN
dti-1335	137	32	production	production	NOUN
dti-1335	137	33	.	.	PUNCT
dti-1335	138	1	we	we	PRON
dti-1335	138	2	have	have	AUX
dti-1335	138	3	shown	show	VERB
dti-1335	138	4	that	that	SCONJ
dti-1335	138	5	reactive	reactive	ADJ
dti-1335	138	6	astrocytes	astrocyte	NOUN
dti-1335	138	7	in	in	ADP
dti-1335	138	8	vitro	vitro	X
dti-1335	138	9	and	and	CCONJ
dti-1335	138	10	in	in	ADP
dti-1335	138	11	situ	situ	NOUN
dti-1335	138	12	upregulate	upregulate	VERB
dti-1335	138	13	igfbp-2	igfbp-2	PROPN
dti-1335	138	14	and	and	CCONJ
dti-1335	138	15	that	that	SCONJ
dti-1335	138	16	combined	combined	ADJ
dti-1335	138	17	treatment	treatment	NOUN
dti-1335	138	18	of	of	ADP
dti-1335	138	19	igfbp-2	igfbp-2	PROPN
dti-1335	138	20	and	and	CCONJ
dti-1335	138	21	igf-1	igf-1	PRON
dti-1335	138	22	does	do	AUX
dti-1335	138	23	not	not	PART
dti-1335	138	24	inhibit	inhibit	VERB
dti-1335	138	25	igf-1	igf-1	ADV
dti-1335	138	26	stimulated	stimulate	VERB
dti-1335	138	27	astrocyte	astrocyte	NOUN
dti-1335	138	28	proliferation	proliferation	NOUN
dti-1335	138	29	,	,	PUNCT
dti-1335	138	30	whereas	whereas	SCONJ
dti-1335	138	31	it	it	PRON
dti-1335	138	32	inhibits	inhibit	VERB
dti-1335	138	33	igf-1	igf-1	SYM
dti-1335	138	34	stimulated	stimulate	VERB
dti-1335	138	35	survival	survival	NOUN
dti-1335	138	36	of	of	ADP
dti-1335	138	37	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	138	38	(	(	PUNCT
dti-1335	138	39	chesik	chesik	NOUN
dti-1335	138	40	et	et	PROPN
dti-1335	138	41	al	al	PROPN
dti-1335	138	42	.	.	PROPN
dti-1335	138	43	2004	2004	NUM
dti-1335	138	44	)	)	PUNCT
dti-1335	138	45	.	.	PUNCT
dti-1335	139	1	we	we	PRON
dti-1335	139	2	propose	propose	VERB
dti-1335	139	3	that	that	SCONJ
dti-1335	139	4	an	an	DET
dti-1335	139	5	upregulation	upregulation	NOUN
dti-1335	139	6	of	of	ADP
dti-1335	139	7	igfbp-2	igfbp-2	PROPN
dti-1335	139	8	in	in	ADP
dti-1335	139	9	ms	ms	PROPN
dti-1335	139	10	facilitates	facilitate	VERB
dti-1335	139	11	the	the	DET
dti-1335	139	12	process	process	NOUN
dti-1335	139	13	of	of	ADP
dti-1335	139	14	astrogliosis	astrogliosis	NOUN
dti-1335	139	15	by	by	ADP
dti-1335	139	16	targeting	target	VERB
dti-1335	139	17	igf-1	igf-1	NOUN
dti-1335	139	18	to	to	ADP
dti-1335	139	19	these	these	DET
dti-1335	139	20	cells	cell	NOUN
dti-1335	139	21	.	.	PUNCT
dti-1335	140	1	inhibition	inhibition	NOUN
dti-1335	140	2	of	of	ADP
dti-1335	140	3	endogenous	endogenous	ADJ
dti-1335	140	4	expression	expression	NOUN
dti-1335	140	5	of	of	ADP
dti-1335	140	6	igfbp-2	igfbp-2	PROPN
dti-1335	140	7	in	in	ADP
dti-1335	140	8	astrocytes	astrocyte	NOUN
dti-1335	140	9	by	by	ADP
dti-1335	140	10	means	mean	NOUN
dti-1335	140	11	of	of	ADP
dti-1335	140	12	micrornas	microrna	NOUN
dti-1335	140	13	(	(	PUNCT
dti-1335	140	14	mirnas	mirna	NOUN
dti-1335	140	15	)	)	PUNCT
dti-1335	140	16	might	might	AUX
dti-1335	140	17	have	have	VERB
dti-1335	140	18	implications	implication	NOUN
dti-1335	140	19	on	on	ADP
dti-1335	140	20	cell	cell	NOUN
dti-1335	140	21	proliferation	proliferation	NOUN
dti-1335	140	22	and	and	CCONJ
dti-1335	140	23	maturation	maturation	NOUN
dti-1335	140	24	of	of	ADP
dti-1335	140	25	these	these	DET
dti-1335	140	26	cells	cell	NOUN
dti-1335	140	27	.	.	PUNCT
dti-1335	141	1	in	in	ADP
dti-1335	141	2	ms	ms	PROPN
dti-1335	141	3	,	,	PUNCT
dti-1335	141	4	astrocytes	astrocyte	NOUN
dti-1335	141	5	become	become	VERB
dti-1335	141	6	reactive	reactive	ADJ
dti-1335	141	7	and	and	CCONJ
dti-1335	141	8	form	form	VERB
dti-1335	141	9	the	the	DET
dti-1335	141	10	glial	glial	ADJ
dti-1335	141	11	scar	scar	NOUN
dti-1335	141	12	,	,	PUNCT
dti-1335	141	13	which	which	PRON
dti-1335	141	14	is	be	AUX
dti-1335	141	15	thought	think	VERB
dti-1335	141	16	to	to	PART
dti-1335	141	17	impede	impede	VERB
dti-1335	141	18	remyelination	remyelination	NOUN
dti-1335	141	19	processes	process	NOUN
dti-1335	141	20	.	.	PUNCT
dti-1335	142	1	mirnas	mirna	NOUN
dti-1335	142	2	are	be	AUX
dti-1335	142	3	a	a	DET
dti-1335	142	4	growing	grow	VERB
dti-1335	142	5	family	family	NOUN
dti-1335	142	6	of	of	ADP
dti-1335	142	7	singlestranded	singlestrande	VERB
dti-1335	142	8	forms	form	NOUN
dti-1335	142	9	of	of	ADP
dti-1335	142	10	rna	rna	NOUN
dti-1335	142	11	,	,	PUNCT
dti-1335	142	12	which	which	PRON
dti-1335	142	13	regulate	regulate	VERB
dti-1335	142	14	the	the	DET
dti-1335	142	15	expression	expression	NOUN
dti-1335	142	16	and	and	CCONJ
dti-1335	142	17	production	production	NOUN
dti-1335	142	18	of	of	ADP
dti-1335	142	19	proteins	protein	NOUN
dti-1335	142	20	.	.	PUNCT
dti-1335	143	1	such	such	DET
dti-1335	143	2	an	an	DET
dti-1335	143	3	approach	approach	NOUN
dti-1335	143	4	was	be	AUX
dti-1335	143	5	already	already	ADV
dti-1335	143	6	investigated	investigate	VERB
dti-1335	143	7	in	in	ADP
dti-1335	143	8	neuroblastoma	neuroblastoma	ADJ
dti-1335	143	9	(	(	PUNCT
dti-1335	143	10	nb	nb	NOUN
dti-1335	143	11	)	)	PUNCT
dti-1335	143	12	cells	cell	NOUN
dti-1335	143	13	(	(	PUNCT
dti-1335	143	14	tanno	tanno	NOUN
dti-1335	143	15	et	et	PROPN
dti-1335	143	16	al	al	PROPN
dti-1335	143	17	.	.	PROPN
dti-1335	143	18	2005	2005	NUM
dti-1335	143	19	)	)	PUNCT
dti-1335	143	20	.	.	PUNCT
dti-1335	144	1	neuroblastoma	neuroblastoma	NOUN
dti-1335	144	2	is	be	AUX
dti-1335	144	3	a	a	DET
dti-1335	144	4	malignant	malignant	ADJ
dti-1335	144	5	childhood	childhood	NOUN
dti-1335	144	6	tumor	tumor	NOUN
dti-1335	144	7	,	,	PUNCT
dti-1335	144	8	in	in	ADP
dti-1335	144	9	which	which	PRON
dti-1335	144	10	igfbp-5	igfbp-5	PRON
dti-1335	144	11	is	be	AUX
dti-1335	144	12	frequently	frequently	ADV
dti-1335	144	13	expressed	express	VERB
dti-1335	144	14	.	.	PUNCT
dti-1335	145	1	by	by	ADP
dti-1335	145	2	suppressing	suppress	VERB
dti-1335	145	3	the	the	DET
dti-1335	145	4	expression	expression	NOUN
dti-1335	145	5	level	level	NOUN
dti-1335	145	6	of	of	ADP
dti-1335	145	7	igfbp-5	igfbp-5	NUM
dti-1335	145	8	in	in	ADP
dti-1335	145	9	nb	nb	NOUN
dti-1335	145	10	cells	cell	NOUN
dti-1335	145	11	through	through	ADP
dti-1335	145	12	mirnas	mirna	NOUN
dti-1335	145	13	,	,	PUNCT
dti-1335	145	14	nb	nb	PROPN
dti-1335	145	15	cells	cell	NOUN
dti-1335	145	16	become	become	VERB
dti-1335	145	17	more	more	ADV
dti-1335	145	18	prone	prone	ADJ
dti-1335	145	19	to	to	ADP
dti-1335	145	20	apoptosis	apoptosis	NOUN
dti-1335	145	21	(	(	PUNCT
dti-1335	145	22	tanno	tanno	NOUN
dti-1335	145	23	et	et	PROPN
dti-1335	145	24	al	al	PROPN
dti-1335	145	25	.	.	PROPN
dti-1335	145	26	2005	2005	NUM
dti-1335	145	27	)	)	PUNCT
dti-1335	145	28	.	.	PUNCT
dti-1335	146	1	the	the	DET
dti-1335	146	2	use	use	NOUN
dti-1335	146	3	of	of	ADP
dti-1335	146	4	these	these	DET
dti-1335	146	5	molecules	molecule	NOUN
dti-1335	146	6	as	as	ADP
dti-1335	146	7	therapeutics	therapeutic	NOUN
dti-1335	146	8	to	to	ADP
dti-1335	146	9	infl	infl	PROPN
dti-1335	146	10	uence	uence	NOUN
dti-1335	146	11	the	the	DET
dti-1335	146	12	expression	expression	NOUN
dti-1335	146	13	of	of	ADP
dti-1335	146	14	igfbps	igfbps	NOUN
dti-1335	146	15	during	during	ADP
dti-1335	146	16	demyelination	demyelination	NOUN
dti-1335	146	17	has	have	VERB
dti-1335	146	18	a	a	DET
dti-1335	146	19	long	long	ADJ
dti-1335	146	20	way	way	NOUN
dti-1335	146	21	to	to	PART
dti-1335	146	22	go	go	VERB
dti-1335	146	23	.	.	PUNCT
dti-1335	147	1	however	however	ADV
dti-1335	147	2	,	,	PUNCT
dti-1335	147	3	regulating	regulate	VERB
dti-1335	147	4	the	the	DET
dti-1335	147	5	expressing	expressing	NOUN
dti-1335	147	6	of	of	ADP
dti-1335	147	7	igfbps	igfbps	NOUN
dti-1335	147	8	through	through	ADP
dti-1335	147	9	mirnas	mirna	NOUN
dti-1335	147	10	opens	open	VERB
dti-1335	147	11	a	a	DET
dti-1335	147	12	new	new	ADJ
dti-1335	147	13	window	window	NOUN
dti-1335	147	14	to	to	PART
dti-1335	147	15	selectively	selectively	ADV
dti-1335	147	16	study	study	VERB
dti-1335	147	17	the	the	DET
dti-1335	147	18	role	role	NOUN
dti-1335	147	19	of	of	ADP
dti-1335	147	20	igfbps	igfbps	NOUN
dti-1335	147	21	in	in	ADP
dti-1335	147	22	several	several	ADJ
dti-1335	147	23	diseases	disease	NOUN
dti-1335	147	24	such	such	ADJ
dti-1335	147	25	as	as	ADP
dti-1335	147	26	ms	ms	PROPN
dti-1335	147	27	.	.	PROPN
dti-1335	147	28	conclusion	conclusion	NOUN
dti-1335	147	29	the	the	DET
dti-1335	147	30	use	use	NOUN
dti-1335	147	31	of	of	ADP
dti-1335	147	32	igf-1	igf-1	NOUN
dti-1335	147	33	analogues	analogue	NOUN
dti-1335	147	34	,	,	PUNCT
dti-1335	147	35	igfbp	igfbp	ADV
dti-1335	147	36	ligand	ligand	VERB
dti-1335	147	37	inhibitors	inhibitor	NOUN
dti-1335	147	38	and	and	CCONJ
dti-1335	147	39	micrornas	microrna	NOUN
dti-1335	147	40	to	to	PART
dti-1335	147	41	modify	modify	VERB
dti-1335	147	42	actions	action	NOUN
dti-1335	147	43	of	of	ADP
dti-1335	147	44	igf-1	igf-1	NOUN
dti-1335	147	45	signaling	signal	VERB
dti-1335	147	46	and	and	CCONJ
dti-1335	147	47	induce	induce	VERB
dti-1335	147	48	remyelination	remyelination	NOUN
dti-1335	147	49	in	in	ADP
dti-1335	147	50	the	the	DET
dti-1335	147	51	cns	cns	NOUN
dti-1335	147	52	43	43	NUM
dti-1335	147	53	targeting	target	VERB
dti-1335	147	54	insulin	insulin	NOUN
dti-1335	147	55	-	-	PUNCT
dti-1335	147	56	like	like	ADJ
dti-1335	147	57	growth	growth	NOUN
dti-1335	147	58	factor-1	factor-1	NUM
dti-1335	147	59	drug	drug	NOUN
dti-1335	147	60	target	target	NOUN
dti-1335	147	61	insights	insight	NOUN
dti-1335	147	62	2008:3	2008:3	NUM
dti-1335	147	63	would	would	AUX
dti-1335	147	64	be	be	AUX
dti-1335	147	65	a	a	DET
dti-1335	147	66	tremendous	tremendous	ADJ
dti-1335	147	67	breakthrough	breakthrough	NOUN
dti-1335	147	68	in	in	ADP
dti-1335	147	69	the	the	DET
dti-1335	147	70	treatment	treatment	NOUN
dti-1335	147	71	of	of	ADP
dti-1335	147	72	human	human	ADJ
dti-1335	147	73	demyelinating	demyelinate	VERB
dti-1335	147	74	diseases	disease	NOUN
dti-1335	147	75	,	,	PUNCT
dti-1335	147	76	such	such	ADJ
dti-1335	147	77	as	as	ADP
dti-1335	147	78	ms	ms	PROPN
dti-1335	147	79	.	.	PROPN
dti-1335	147	80	the	the	DET
dti-1335	147	81	unique	unique	ADJ
dti-1335	147	82	distribution	distribution	NOUN
dti-1335	147	83	of	of	ADP
dti-1335	147	84	igfbps	igfbps	NOUN
dti-1335	147	85	in	in	ADP
dti-1335	147	86	ms	ms	ADJ
dti-1335	147	87	lesions	lesion	NOUN
dti-1335	147	88	as	as	ADV
dti-1335	147	89	well	well	ADV
dti-1335	147	90	as	as	ADP
dti-1335	147	91	a	a	DET
dti-1335	147	92	unique	unique	ADJ
dti-1335	147	93	functional	functional	ADJ
dti-1335	147	94	characteristic	characteristic	NOUN
dti-1335	147	95	of	of	ADP
dti-1335	147	96	the	the	DET
dti-1335	147	97	igf-1	igf-1	NOUN
dti-1335	147	98	receptor	receptor	NOUN
dti-1335	147	99	on	on	ADP
dti-1335	147	100	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	147	101	offers	offer	VERB
dti-1335	147	102	a	a	DET
dti-1335	147	103	means	means	NOUN
dti-1335	147	104	to	to	PART
dti-1335	147	105	specifi	specifi	AUX
dti-1335	147	106	cally	cally	ADV
dti-1335	147	107	target	target	VERB
dti-1335	147	108	this	this	DET
dti-1335	147	109	cell	cell	NOUN
dti-1335	147	110	type	type	NOUN
dti-1335	147	111	.	.	PUNCT
dti-1335	148	1	acknowledgments	acknowledgment	NOUN
dti-1335	148	2	this	this	DET
dti-1335	148	3	work	work	NOUN
dti-1335	148	4	was	be	AUX
dti-1335	148	5	supported	support	VERB
dti-1335	148	6	by	by	ADP
dti-1335	148	7	the	the	DET
dti-1335	148	8	school	school	NOUN
dti-1335	148	9	of	of	ADP
dti-1335	148	10	behavior	behavior	NOUN
dti-1335	148	11	and	and	CCONJ
dti-1335	148	12	cognitative	cognitative	ADJ
dti-1335	148	13	neurosciences	neuroscience	NOUN
dti-1335	148	14	(	(	PUNCT
dti-1335	148	15	bcn	bcn	PROPN
dti-1335	148	16	)	)	PUNCT
dti-1335	148	17	groningen	groningen	NOUN
dti-1335	148	18	and	and	CCONJ
dti-1335	148	19	“	"	PUNCT
dti-1335	148	20	msanders	msander	NOUN
dti-1335	148	21	”	"	PUNCT
dti-1335	148	22	,	,	PUNCT
dti-1335	148	23	the	the	DET
dti-1335	148	24	netherlands	netherlands	PROPN
dti-1335	148	25	.	.	PUNCT
dti-1335	149	1	references	reference	NOUN
dti-1335	149	2	anlar	anlar	ADJ
dti-1335	149	3	,	,	PUNCT
dti-1335	149	4	b.	b.	PROPN
dti-1335	149	5	,	,	PUNCT
dti-1335	149	6	sullivan	sullivan	PROPN
dti-1335	149	7	,	,	PUNCT
dti-1335	149	8	k.a	k.a	PROPN
dti-1335	149	9	.	.	PROPN
dti-1335	149	10	and	and	CCONJ
dti-1335	149	11	feldman	feldman	PROPN
dti-1335	149	12	,	,	PUNCT
dti-1335	149	13	e.l	e.l	PROPN
dti-1335	149	14	.	.	PROPN
dti-1335	149	15	1999	1999	NUM
dti-1335	149	16	.	.	PUNCT
dti-1335	150	1	insulin	insulin	NOUN
dti-1335	150	2	-	-	PUNCT
dti-1335	150	3	like	like	ADJ
dti-1335	150	4	growth	growth	NOUN
dti-1335	150	5	factor	factor	NOUN
dti-1335	150	6	-	-	PUNCT
dti-1335	150	7	i	i	PROPN
dti-1335	150	8	and	and	CCONJ
dti-1335	150	9	central	central	ADJ
dti-1335	150	10	nervous	nervous	ADJ
dti-1335	150	11	system	system	NOUN
dti-1335	150	12	development	development	NOUN
dti-1335	150	13	.	.	PUNCT
dti-1335	151	1	horm	horm	NOUN
dti-1335	151	2	.	.	PUNCT
dti-1335	152	1	metab	metab	PROPN
dti-1335	152	2	.	.	PUNCT
dti-1335	153	1	res	re	NOUN
dti-1335	153	2	.	.	PROPN
dti-1335	153	3	,	,	PUNCT
dti-1335	153	4	31:120–5	31:120–5	NUM
dti-1335	153	5	.	.	PUNCT
dti-1335	154	1	baxter	baxter	PROPN
dti-1335	154	2	,	,	PUNCT
dti-1335	154	3	r.c	r.c	PROPN
dti-1335	154	4	.	.	PROPN
dti-1335	154	5	1994	1994	NUM
dti-1335	154	6	.	.	PUNCT
dti-1335	155	1	insulin	insulin	NOUN
dti-1335	155	2	-	-	PUNCT
dti-1335	155	3	like	like	ADJ
dti-1335	155	4	growth	growth	NOUN
dti-1335	155	5	factor	factor	NOUN
dti-1335	155	6	binding	bind	VERB
dti-1335	155	7	proteins	protein	NOUN
dti-1335	155	8	in	in	ADP
dti-1335	155	9	the	the	DET
dti-1335	155	10	human	human	ADJ
dti-1335	155	11	circulation	circulation	NOUN
dti-1335	155	12	:	:	PUNCT
dti-1335	155	13	a	a	DET
dti-1335	155	14	review	review	NOUN
dti-1335	155	15	.	.	PUNCT
dti-1335	156	1	horm	horm	PROPN
dti-1335	156	2	.	.	PUNCT
dti-1335	157	1	res	re	NOUN
dti-1335	157	2	.	.	PROPN
dti-1335	157	3	,	,	PUNCT
dti-1335	157	4	42:140–4	42:140–4	NUM
dti-1335	157	5	.	.	PUNCT
dti-1335	157	6	beck	beck	PROPN
dti-1335	157	7	,	,	PUNCT
dti-1335	157	8	f.	f.	PROPN
dti-1335	157	9	,	,	PUNCT
dti-1335	157	10	samani	samani	PROPN
dti-1335	157	11	,	,	PUNCT
dti-1335	157	12	n.j	n.j	PROPN
dti-1335	157	13	.	.	PROPN
dti-1335	157	14	,	,	PUNCT
dti-1335	157	15	byrne	byrne	PROPN
dti-1335	157	16	,	,	PUNCT
dti-1335	157	17	s.	s.	PROPN
dti-1335	157	18	et	et	PROPN
dti-1335	157	19	al	al	PROPN
dti-1335	157	20	.	.	PROPN
dti-1335	157	21	1988	1988	NUM
dti-1335	157	22	.	.	PUNCT
dti-1335	158	1	histochemical	histochemical	ADJ
dti-1335	158	2	localization	localization	NOUN
dti-1335	158	3	of	of	ADP
dti-1335	158	4	igf-1	igf-1	NOUN
dti-1335	158	5	and	and	CCONJ
dti-1335	158	6	igf	igf	PROPN
dti-1335	158	7	-	-	PROPN
dti-1335	158	8	ii	ii	PROPN
dti-1335	158	9	mrna	mrna	NOUN
dti-1335	158	10	in	in	ADP
dti-1335	158	11	the	the	DET
dti-1335	158	12	rat	rat	NOUN
dti-1335	158	13	between	between	ADP
dti-1335	158	14	birth	birth	NOUN
dti-1335	158	15	and	and	CCONJ
dti-1335	158	16	adulthood	adulthood	NOUN
dti-1335	158	17	.	.	PUNCT
dti-1335	159	1	development	development	NOUN
dti-1335	159	2	,	,	PUNCT
dti-1335	159	3	104:29–39	104:29–39	PROPN
dti-1335	159	4	.	.	PUNCT
dti-1335	159	5	beck	beck	PROPN
dti-1335	159	6	,	,	PUNCT
dti-1335	159	7	k.d	k.d	PROPN
dti-1335	159	8	.	.	PROPN
dti-1335	159	9	,	,	PUNCT
dti-1335	159	10	powell	powell	PROPN
dti-1335	159	11	-	-	PUNCT
dti-1335	159	12	braxton	braxton	PROPN
dti-1335	159	13	,	,	PUNCT
dti-1335	159	14	l.	l.	PROPN
dti-1335	159	15	,	,	PUNCT
dti-1335	159	16	widmer	widmer	PROPN
dti-1335	159	17	,	,	PUNCT
dti-1335	159	18	h.r	h.r	PROPN
dti-1335	159	19	.	.	PROPN
dti-1335	159	20	et	et	PROPN
dti-1335	159	21	al	al	PROPN
dti-1335	159	22	.	.	PROPN
dti-1335	159	23	1995	1995	NUM
dti-1335	159	24	.	.	PUNCT
dti-1335	160	1	igf1	igf1	PROPN
dti-1335	160	2	gene	gene	NOUN
dti-1335	160	3	disruption	disruption	NOUN
dti-1335	160	4	results	result	NOUN
dti-1335	160	5	in	in	ADP
dti-1335	160	6	reduced	reduced	ADJ
dti-1335	160	7	brain	brain	NOUN
dti-1335	160	8	size	size	NOUN
dti-1335	160	9	,	,	PUNCT
dti-1335	160	10	cns	cns	NOUN
dti-1335	160	11	hypomyelination	hypomyelination	NOUN
dti-1335	160	12	,	,	PUNCT
dti-1335	160	13	and	and	CCONJ
dti-1335	160	14	loss	loss	NOUN
dti-1335	160	15	of	of	ADP
dti-1335	160	16	granule	granule	NOUN
dti-1335	160	17	and	and	CCONJ
dti-1335	160	18	striatal	striatal	ADJ
dti-1335	160	19	parvalbumin	parvalbumin	NOUN
dti-1335	160	20	-	-	PUNCT
dti-1335	160	21	containing	contain	VERB
dti-1335	160	22	neurons	neuron	NOUN
dti-1335	160	23	.	.	PUNCT
dti-1335	161	1	neuron	neuron	PROPN
dti-1335	161	2	,	,	PUNCT
dti-1335	161	3	14:717–30	14:717–30	NUM
dti-1335	161	4	.	.	PUNCT
dti-1335	162	1	bondy	bondy	PROPN
dti-1335	162	2	,	,	PUNCT
dti-1335	162	3	c.a	c.a	PROPN
dti-1335	162	4	.	.	PROPN
dti-1335	162	5	and	and	CCONJ
dti-1335	162	6	cheng	cheng	PROPN
dti-1335	162	7	,	,	PUNCT
dti-1335	162	8	c.m	c.m	PROPN
dti-1335	162	9	.	.	PROPN
dti-1335	162	10	2004	2004	NUM
dti-1335	162	11	.	.	PUNCT
dti-1335	163	1	signaling	signal	VERB
dti-1335	163	2	by	by	ADP
dti-1335	163	3	insulin	insulin	NOUN
dti-1335	163	4	-	-	PUNCT
dti-1335	163	5	like	like	ADJ
dti-1335	163	6	growth	growth	NOUN
dti-1335	163	7	factor	factor	NOUN
dti-1335	163	8	i	i	PRON
dti-1335	163	9	in	in	ADP
dti-1335	163	10	brain	brain	NOUN
dti-1335	163	11	.	.	PUNCT
dti-1335	164	1	eur	eur	PROPN
dti-1335	164	2	.	.	PUNCT
dti-1335	165	1	j.	j.	PROPN
dti-1335	165	2	pharmacol	pharmacol	PROPN
dti-1335	165	3	.	.	PROPN
dti-1335	165	4	,	,	PUNCT
dti-1335	166	1	490:25–31	490:25–31	X
dti-1335	166	2	.	.	PUNCT
dti-1335	166	3	bondy	bondy	PROPN
dti-1335	166	4	,	,	PUNCT
dti-1335	166	5	c.	c.	PROPN
dti-1335	166	6	,	,	PUNCT
dti-1335	166	7	werner	werner	PROPN
dti-1335	166	8	,	,	PUNCT
dti-1335	166	9	h.	h.	PROPN
dti-1335	166	10	,	,	PUNCT
dti-1335	166	11	roberts	roberts	PROPN
dti-1335	166	12	,	,	PUNCT
dti-1335	166	13	ct	ct	PROPN
dti-1335	166	14	.	.	PROPN
dti-1335	166	15	,	,	PUNCT
dti-1335	166	16	jr	jr	PROPN
dti-1335	166	17	.	.	PROPN
dti-1335	166	18	et	et	PROPN
dti-1335	166	19	al	al	PROPN
dti-1335	166	20	.	.	PROPN
dti-1335	166	21	1992	1992	NUM
dti-1335	166	22	.	.	PUNCT
dti-1335	167	1	cellular	cellular	ADJ
dti-1335	167	2	pattern	pattern	NOUN
dti-1335	167	3	of	of	ADP
dti-1335	167	4	type	type	NOUN
dti-1335	167	5	-	-	PUNCT
dti-1335	167	6	i	i	PRON
dti-1335	167	7	insulin	insulin	NOUN
dti-1335	167	8	-	-	PUNCT
dti-1335	167	9	like	like	ADJ
dti-1335	167	10	growth	growth	NOUN
dti-1335	167	11	factor	factor	NOUN
dti-1335	167	12	receptor	receptor	NOUN
dti-1335	167	13	gene	gene	NOUN
dti-1335	167	14	expression	expression	NOUN
dti-1335	167	15	during	during	ADP
dti-1335	167	16	maturation	maturation	NOUN
dti-1335	167	17	of	of	ADP
dti-1335	167	18	the	the	DET
dti-1335	167	19	rat	rat	NOUN
dti-1335	167	20	brain	brain	NOUN
dti-1335	167	21	:	:	PUNCT
dti-1335	167	22	comparison	comparison	NOUN
dti-1335	167	23	with	with	ADP
dti-1335	167	24	insulin	insulin	NOUN
dti-1335	167	25	-	-	PUNCT
dti-1335	167	26	like	like	ADJ
dti-1335	167	27	growth	growth	NOUN
dti-1335	167	28	factors	factor	NOUN
dti-1335	167	29	i	i	PRON
dti-1335	167	30	and	and	CCONJ
dti-1335	167	31	ii	ii	PROPN
dti-1335	167	32	.	.	PROPN
dti-1335	167	33	neuroscience	neuroscience	PROPN
dti-1335	167	34	,	,	PUNCT
dti-1335	167	35	46:909–23	46:909–23	PROPN
dti-1335	167	36	.	.	PUNCT
dti-1335	168	1	brunet	brunet	PROPN
dti-1335	168	2	,	,	PUNCT
dti-1335	168	3	a.	a.	NOUN
dti-1335	168	4	,	,	PUNCT
dti-1335	168	5	bonni	bonni	PROPN
dti-1335	168	6	,	,	PUNCT
dti-1335	168	7	a.	a.	NOUN
dti-1335	168	8	,	,	PUNCT
dti-1335	168	9	zigmond	zigmond	PROPN
dti-1335	168	10	,	,	PUNCT
dti-1335	168	11	m.j	m.j	PROPN
dti-1335	168	12	.	.	PROPN
dti-1335	168	13	et	et	PROPN
dti-1335	168	14	al	al	PROPN
dti-1335	168	15	.	.	PROPN
dti-1335	168	16	1999	1999	NUM
dti-1335	168	17	.	.	PUNCT
dti-1335	169	1	akt	akt	PROPN
dti-1335	169	2	promotes	promote	VERB
dti-1335	169	3	cell	cell	NOUN
dti-1335	169	4	survival	survival	NOUN
dti-1335	169	5	by	by	ADP
dti-1335	169	6	phosphorylating	phosphorylate	VERB
dti-1335	169	7	and	and	CCONJ
dti-1335	169	8	inhibiting	inhibit	VERB
dti-1335	169	9	a	a	DET
dti-1335	169	10	forkhead	forkhead	NOUN
dti-1335	169	11	transcription	transcription	NOUN
dti-1335	169	12	factor	factor	NOUN
dti-1335	169	13	.	.	PUNCT
dti-1335	170	1	cell	cell	NOUN
dti-1335	170	2	,	,	PUNCT
dti-1335	170	3	96:857–68	96:857–68	PROPN
dti-1335	170	4	.	.	PUNCT
dti-1335	171	1	canella	canella	PROPN
dti-1335	171	2	,	,	PUNCT
dti-1335	171	3	b.	b.	PROPN
dti-1335	171	4	,	,	PUNCT
dti-1335	171	5	pitt	pitt	PROPN
dti-1335	171	6	,	,	PUNCT
dti-1335	171	7	d.	d.	PROPN
dti-1335	171	8	,	,	PUNCT
dti-1335	171	9	capello	capello	PROPN
dti-1335	171	10	,	,	PUNCT
dti-1335	171	11	e.	e.	PROPN
dti-1335	171	12	et	et	PROPN
dti-1335	171	13	al	al	PROPN
dti-1335	171	14	.	.	PROPN
dti-1335	171	15	2000	2000	NUM
dti-1335	171	16	.	.	PUNCT
dti-1335	172	1	insulin	insulin	NOUN
dti-1335	172	2	-	-	PUNCT
dti-1335	172	3	like	like	ADJ
dti-1335	172	4	growth	growth	NOUN
dti-1335	172	5	factor-1	factor-1	NUM
dti-1335	172	6	fails	fail	VERB
dti-1335	172	7	to	to	PART
dti-1335	172	8	enhance	enhance	VERB
dti-1335	172	9	central	central	ADJ
dti-1335	172	10	nervous	nervous	ADJ
dti-1335	172	11	system	system	NOUN
dti-1335	172	12	myelin	myelin	NOUN
dti-1335	172	13	repair	repair	NOUN
dti-1335	172	14	during	during	ADP
dti-1335	172	15	autoimmune	autoimmune	ADJ
dti-1335	172	16	demyelination	demyelination	NOUN
dti-1335	172	17	.	.	PUNCT
dti-1335	173	1	am	be	AUX
dti-1335	173	2	.	.	PUNCT
dti-1335	174	1	j.	j.	PROPN
dti-1335	174	2	pathol	pathol	PROPN
dti-1335	174	3	.	.	PROPN
dti-1335	174	4	,	,	PUNCT
dti-1335	174	5	157:933–43	157:933–43	PROPN
dti-1335	174	6	.	.	PUNCT
dti-1335	175	1	carson	carson	PROPN
dti-1335	175	2	,	,	PUNCT
dti-1335	175	3	m.j	m.j	PROPN
dti-1335	175	4	.	.	PROPN
dti-1335	175	5	,	,	PUNCT
dti-1335	175	6	behringer	behringer	PROPN
dti-1335	175	7	,	,	PUNCT
dti-1335	175	8	r.r	r.r	PROPN
dti-1335	175	9	.	.	PROPN
dti-1335	175	10	,	,	PUNCT
dti-1335	175	11	brinster	brinster	PROPN
dti-1335	175	12	,	,	PUNCT
dti-1335	175	13	r.l	r.l	PROPN
dti-1335	175	14	.	.	PROPN
dti-1335	175	15	et	et	PROPN
dti-1335	175	16	al	al	PROPN
dti-1335	175	17	.	.	PROPN
dti-1335	175	18	1993	1993	NUM
dti-1335	175	19	.	.	PUNCT
dti-1335	176	1	insulin	insulin	NOUN
dti-1335	176	2	-	-	PUNCT
dti-1335	176	3	like	like	ADJ
dti-1335	176	4	growth	growth	NOUN
dti-1335	176	5	factor	factor	NOUN
dti-1335	176	6	-	-	PUNCT
dti-1335	176	7	i	i	PRON
dti-1335	176	8	increases	increase	VERB
dti-1335	176	9	brain	brain	NOUN
dti-1335	176	10	growth	growth	NOUN
dti-1335	176	11	and	and	CCONJ
dti-1335	176	12	central	central	ADJ
dti-1335	176	13	nervous	nervous	ADJ
dti-1335	176	14	system	system	NOUN
dti-1335	176	15	myelination	myelination	NOUN
dti-1335	176	16	in	in	ADP
dti-1335	176	17	transgenic	transgenic	NOUN
dti-1335	176	18	mice	mouse	NOUN
dti-1335	176	19	.	.	PUNCT
dti-1335	177	1	neuron	neuron	PROPN
dti-1335	177	2	,	,	PUNCT
dti-1335	177	3	10:729–40	10:729–40	NUM
dti-1335	177	4	.	.	PUNCT
dti-1335	177	5	caro	caro	PROPN
dti-1335	177	6	,	,	PUNCT
dti-1335	177	7	e.	e.	PROPN
dti-1335	177	8	,	,	PUNCT
dti-1335	177	9	spuch	spuch	PROPN
dti-1335	177	10	,	,	PUNCT
dti-1335	177	11	c.	c.	PROPN
dti-1335	177	12	,	,	PUNCT
dti-1335	177	13	trejo	trejo	PROPN
dti-1335	177	14	,	,	PUNCT
dti-1335	177	15	j.l	j.l	PROPN
dti-1335	177	16	.	.	PROPN
dti-1335	177	17	et	et	PROPN
dti-1335	177	18	al	al	PROPN
dti-1335	177	19	.	.	PROPN
dti-1335	177	20	2005	2005	NUM
dti-1335	177	21	.	.	PUNCT
dti-1335	178	1	choroid	choroid	PROPN
dti-1335	178	2	plexus	plexus	PROPN
dti-1335	178	3	megalin	megalin	NOUN
dti-1335	178	4	is	be	AUX
dti-1335	178	5	involved	involve	VERB
dti-1335	178	6	in	in	ADP
dti-1335	178	7	neuroprotection	neuroprotection	NOUN
dti-1335	178	8	by	by	ADP
dti-1335	178	9	serum	serum	NOUN
dti-1335	178	10	insulin	insulin	NOUN
dti-1335	178	11	-	-	PUNCT
dti-1335	178	12	like	like	ADJ
dti-1335	178	13	growth	growth	NOUN
dti-1335	178	14	factor	factor	NOUN
dti-1335	178	15	-	-	PUNCT
dti-1335	178	16	i.	i.	PROPN
dti-1335	178	17	j.	j.	PROPN
dti-1335	178	18	neurosci	neurosci	PROPN
dti-1335	178	19	.	.	PROPN
dti-1335	179	1	,	,	PUNCT
dti-1335	179	2	25:10884–93	25:10884–93	NUM
dti-1335	179	3	.	.	X
dti-1335	180	1	chang	chang	PROPN
dti-1335	180	2	,	,	PUNCT
dti-1335	180	3	a.	a.	PROPN
dti-1335	180	4	,	,	PUNCT
dti-1335	180	5	tourtellotte	tourtellotte	NOUN
dti-1335	180	6	,	,	PUNCT
dti-1335	180	7	w.w	w.w	PROPN
dti-1335	180	8	.	.	PROPN
dti-1335	180	9	,	,	PUNCT
dti-1335	180	10	rudick	rudick	PROPN
dti-1335	180	11	,	,	PUNCT
dti-1335	180	12	r.	r.	PROPN
dti-1335	180	13	et	et	PROPN
dti-1335	180	14	al	al	PROPN
dti-1335	180	15	.	.	PROPN
dti-1335	180	16	2002	2002	NUM
dti-1335	180	17	.	.	PUNCT
dti-1335	181	1	premyelinating	premyelinate	VERB
dti-1335	181	2	oligodendrocytes	oligodendrocyte	NOUN
dti-1335	181	3	in	in	ADP
dti-1335	181	4	chronic	chronic	ADJ
dti-1335	181	5	lesions	lesion	NOUN
dti-1335	181	6	of	of	ADP
dti-1335	181	7	multiple	multiple	ADJ
dti-1335	181	8	sclerosis	sclerosis	NOUN
dti-1335	181	9	.	.	PUNCT
dti-1335	182	1	n.	n.	PROPN
dti-1335	182	2	engl	engl	PROPN
dti-1335	182	3	.	.	PUNCT
dti-1335	183	1	j.	j.	PROPN
dti-1335	183	2	med	med	PROPN
dti-1335	183	3	.	.	PROPN
dti-1335	183	4	,	,	PUNCT
dti-1335	183	5	346:165–73	346:165–73	NUM
dti-1335	183	6	.	.	PUNCT
dti-1335	184	1	chen	chen	PROPN
dti-1335	184	2	,	,	PUNCT
dti-1335	184	3	c.	c.	PROPN
dti-1335	184	4	,	,	PUNCT
dti-1335	184	5	zhu	zhu	PROPN
dti-1335	184	6	,	,	PUNCT
dti-1335	184	7	y.f	y.f	PROPN
dti-1335	184	8	.	.	PROPN
dti-1335	184	9	,	,	PUNCT
dti-1335	184	10	liu	liu	PROPN
dti-1335	184	11	,	,	PUNCT
dti-1335	184	12	x.j	x.j	PROPN
dti-1335	184	13	.	.	PROPN
dti-1335	184	14	et	et	PROPN
dti-1335	184	15	al	al	PROPN
dti-1335	184	16	.	.	PROPN
dti-1335	184	17	2001	2001	NUM
dti-1335	184	18	.	.	PUNCT
dti-1335	185	1	discovery	discovery	NOUN
dti-1335	185	2	of	of	ADP
dti-1335	185	3	a	a	DET
dti-1335	185	4	series	series	NOUN
dti-1335	185	5	of	of	ADP
dti-1335	185	6	non	non	ADJ
dti-1335	185	7	-	-	ADJ
dti-1335	185	8	peptide	peptide	ADJ
dti-1335	185	9	small	small	ADJ
dti-1335	185	10	molecules	molecule	NOUN
dti-1335	185	11	that	that	PRON
dti-1335	185	12	inhibit	inhibit	VERB
dti-1335	185	13	the	the	DET
dti-1335	185	14	binding	binding	NOUN
dti-1335	185	15	of	of	ADP
dti-1335	185	16	insulin	insulin	NOUN
dti-1335	185	17	-	-	PUNCT
dti-1335	185	18	like	like	ADJ
dti-1335	185	19	growth	growth	NOUN
dti-1335	185	20	factor	factor	NOUN
dti-1335	185	21	(	(	PUNCT
dti-1335	185	22	igf	igf	PROPN
dti-1335	185	23	)	)	PUNCT
dti-1335	185	24	to	to	ADP
dti-1335	185	25	igf	igf	NOUN
dti-1335	185	26	-	-	ADJ
dti-1335	185	27	binding	binding	ADJ
dti-1335	185	28	proteins	protein	NOUN
dti-1335	185	29	.	.	PUNCT
dti-1335	186	1	j.	j.	PROPN
dti-1335	186	2	med	med	PROPN
dti-1335	186	3	.	.	PROPN
dti-1335	186	4	chem	chem	PROPN
dti-1335	186	5	.	.	PUNCT
dti-1335	186	6	,	,	PUNCT
dti-1335	186	7	44:4001–10	44:4001–10	X
dti-1335	186	8	.	.	PUNCT
dti-1335	187	1	cheng	cheng	PROPN
dti-1335	187	2	,	,	PUNCT
dti-1335	187	3	c.m	c.m	PROPN
dti-1335	187	4	.	.	PROPN
dti-1335	187	5	,	,	PUNCT
dti-1335	187	6	reinhardt	reinhardt	PROPN
dti-1335	187	7	,	,	PUNCT
dti-1335	187	8	r.r	r.r	PROPN
dti-1335	187	9	.	.	PROPN
dti-1335	187	10	,	,	PUNCT
dti-1335	187	11	lee	lee	PROPN
dti-1335	187	12	,	,	PUNCT
dti-1335	187	13	w.h	w.h	PROPN
dti-1335	187	14	.	.	PROPN
dti-1335	187	15	et	et	PROPN
dti-1335	187	16	al	al	PROPN
dti-1335	187	17	.	.	PROPN
dti-1335	187	18	2000	2000	NUM
dti-1335	187	19	.	.	PUNCT
dti-1335	188	1	insulin	insulin	NOUN
dti-1335	188	2	-	-	PUNCT
dti-1335	188	3	like	like	ADJ
dti-1335	188	4	growth	growth	NOUN
dti-1335	188	5	factor	factor	NOUN
dti-1335	188	6	-	-	PUNCT
dti-1335	188	7	i	i	PRON
dti-1335	188	8	regulates	regulate	VERB
dti-1335	188	9	developing	develop	VERB
dti-1335	188	10	brain	brain	NOUN
dti-1335	188	11	glucose	glucose	NOUN
dti-1335	188	12	metabolism	metabolism	NOUN
dti-1335	188	13	.	.	PUNCT
dti-1335	189	1	proc	proc	NOUN
dti-1335	189	2	.	.	PUNCT
dti-1335	190	1	natl	natl	PROPN
dti-1335	190	2	.	.	PUNCT
dti-1335	191	1	acad	acad	PROPN
dti-1335	191	2	.	.	PUNCT
dti-1335	192	1	sci	sci	PROPN
dti-1335	192	2	.	.	PROPN
dti-1335	192	3	,	,	PUNCT
dti-1335	192	4	u.s.a	u.s.a	PROPN
dti-1335	192	5	.	.	PROPN
dti-1335	192	6	,	,	PUNCT
dti-1335	192	7	97:10236–41	97:10236–41	X
dti-1335	192	8	.	.	PUNCT
dti-1335	193	1	cheng	cheng	PROPN
dti-1335	193	2	,	,	PUNCT
dti-1335	193	3	h.l	h.l	PROPN
dti-1335	193	4	.	.	PROPN
dti-1335	193	5	,	,	PUNCT
dti-1335	193	6	russel	russel	PROPN
dti-1335	193	7	,	,	PUNCT
dti-1335	193	8	j.w	j.w	PROPN
dti-1335	193	9	.	.	PROPN
dti-1335	193	10	,	,	PUNCT
dti-1335	193	11	feldman	feldman	PROPN
dti-1335	193	12	,	,	PUNCT
dti-1335	193	13	e.l	e.l	PROPN
dti-1335	193	14	.	.	PROPN
dti-1335	193	15	et	et	PROPN
dti-1335	193	16	al	al	PROPN
dti-1335	193	17	.	.	PROPN
dti-1335	193	18	1999	1999	NUM
dti-1335	193	19	.	.	PUNCT
dti-1335	194	1	igf	igf	PROPN
dti-1335	194	2	-	-	PROPN
dti-1335	194	3	i	i	PRON
dti-1335	194	4	promotes	promote	VERB
dti-1335	194	5	peripheral	peripheral	ADJ
dti-1335	194	6	nervous	nervous	ADJ
dti-1335	194	7	system	system	NOUN
dti-1335	194	8	myelination	myelination	NOUN
dti-1335	194	9	.	.	PUNCT
dti-1335	195	1	ann	ann	PROPN
dti-1335	195	2	.	.	PUNCT
dti-1335	195	3	n.y	n.y	PROPN
dti-1335	195	4	.	.	PROPN
dti-1335	195	5	acad	acad	PROPN
dti-1335	195	6	.	.	PUNCT
dti-1335	196	1	sci	sci	PROPN
dti-1335	196	2	.	.	PROPN
dti-1335	196	3	,	,	PUNCT
dti-1335	196	4	883:124–30	883:124–30	PROPN
dti-1335	196	5	.	.	PUNCT
dti-1335	196	6	chesik	chesik	PROPN
dti-1335	196	7	,	,	PUNCT
dti-1335	196	8	d.	d.	PROPN
dti-1335	196	9	,	,	PUNCT
dti-1335	196	10	de	de	PROPN
dti-1335	196	11	keyser	keyser	PROPN
dti-1335	196	12	,	,	PUNCT
dti-1335	196	13	j.	j.	PROPN
dti-1335	196	14	,	,	PUNCT
dti-1335	196	15	glazenburg	glazenburg	PROPN
dti-1335	196	16	,	,	PUNCT
dti-1335	196	17	l.	l.	PROPN
dti-1335	196	18	et	et	PROPN
dti-1335	196	19	al	al	PROPN
dti-1335	196	20	.	.	PROPN
dti-1335	196	21	2006	2006	NUM
dti-1335	196	22	.	.	PUNCT
dti-1335	197	1	insulin	insulin	NOUN
dti-1335	197	2	-	-	PUNCT
dti-1335	197	3	like	like	ADJ
dti-1335	197	4	growth	growth	NOUN
dti-1335	197	5	factor	factor	NOUN
dti-1335	197	6	binding	bind	VERB
dti-1335	197	7	proteins	protein	NOUN
dti-1335	197	8	:	:	PUNCT
dti-1335	197	9	regulation	regulation	NOUN
dti-1335	197	10	in	in	ADP
dti-1335	197	11	chronic	chronic	ADJ
dti-1335	197	12	active	active	ADJ
dti-1335	197	13	plaques	plaque	NOUN
dti-1335	197	14	in	in	ADP
dti-1335	197	15	multiple	multiple	ADJ
dti-1335	197	16	sclerosis	sclerosis	NOUN
dti-1335	197	17	and	and	CCONJ
dti-1335	197	18	functional	functional	ADJ
dti-1335	197	19	analysis	analysis	NOUN
dti-1335	197	20	on	on	ADP
dti-1335	197	21	glial	glial	ADJ
dti-1335	197	22	cells	cell	NOUN
dti-1335	197	23	.	.	PUNCT
dti-1335	198	1	eur	eur	PROPN
dti-1335	198	2	.	.	PUNCT
dti-1335	199	1	j.	j.	PROPN
dti-1335	199	2	neurosci	neurosci	PROPN
dti-1335	199	3	.	.	PROPN
dti-1335	199	4	,	,	PUNCT
dti-1335	199	5	24:1645–52	24:1645–52	X
dti-1335	199	6	.	.	PUNCT
dti-1335	199	7	chesik	chesik	PROPN
dti-1335	199	8	,	,	PUNCT
dti-1335	199	9	d.	d.	PROPN
dti-1335	199	10	,	,	PUNCT
dti-1335	199	11	kühl	kühl	PROPN
dti-1335	199	12	,	,	PUNCT
dti-1335	199	13	n.m	n.m	PROPN
dti-1335	199	14	.	.	PROPN
dti-1335	199	15	,	,	PUNCT
dti-1335	199	16	wilczak	wilczak	PROPN
dti-1335	199	17	,	,	PUNCT
dti-1335	199	18	n.	n.	PROPN
dti-1335	199	19	et	et	PROPN
dti-1335	199	20	al	al	PROPN
dti-1335	199	21	.	.	PROPN
dti-1335	199	22	2004	2004	NUM
dti-1335	199	23	.	.	PUNCT
dti-1335	200	1	enhanced	enhance	VERB
dti-1335	200	2	production	production	NOUN
dti-1335	200	3	and	and	CCONJ
dti-1335	200	4	proteolytic	proteolytic	ADJ
dti-1335	200	5	degradation	degradation	NOUN
dti-1335	200	6	of	of	ADP
dti-1335	200	7	insulin	insulin	NOUN
dti-1335	200	8	-	-	PUNCT
dti-1335	200	9	like	like	ADJ
dti-1335	200	10	growth	growth	NOUN
dti-1335	200	11	factor	factor	NOUN
dti-1335	200	12	binding	bind	VERB
dti-1335	200	13	protein2	protein2	NOUN
dti-1335	200	14	in	in	ADP
dti-1335	200	15	proliferating	proliferate	VERB
dti-1335	200	16	astrocytes	astrocyte	NOUN
dti-1335	200	17	.	.	PUNCT
dti-1335	201	1	j.	j.	PROPN
dti-1335	201	2	neurosci	neurosci	PROPN
dti-1335	201	3	.	.	PUNCT
dti-1335	202	1	res	re	NOUN
dti-1335	202	2	.	.	PROPN
dti-1335	202	3	,	,	PUNCT
dti-1335	202	4	77:354–62	77:354–62	NOUN
dti-1335	202	5	.	.	PUNCT
dti-1335	203	1	clemmons	clemmons	PROPN
dti-1335	203	2	,	,	PUNCT
dti-1335	203	3	d.r	d.r	PROPN
dti-1335	203	4	.	.	PROPN
dti-1335	203	5	1997	1997	NUM
dti-1335	203	6	.	.	PUNCT
dti-1335	204	1	insulin	insulin	NOUN
dti-1335	204	2	-	-	PUNCT
dti-1335	204	3	like	like	ADJ
dti-1335	204	4	growth	growth	NOUN
dti-1335	204	5	factor	factor	NOUN
dti-1335	204	6	binding	bind	VERB
dti-1335	204	7	proteins	protein	NOUN
dti-1335	204	8	and	and	CCONJ
dti-1335	204	9	their	their	PRON
dti-1335	204	10	role	role	NOUN
dti-1335	204	11	in	in	ADP
dti-1335	204	12	controlling	control	VERB
dti-1335	204	13	igf	igf	PROPN
dti-1335	204	14	actions	action	NOUN
dti-1335	204	15	.	.	PUNCT
dti-1335	205	1	cytokine	cytokine	ADJ
dti-1335	205	2	growth	growth	NOUN
dti-1335	205	3	factor	factor	NOUN
dti-1335	205	4	rev	rev	VERB
dti-1335	205	5	.	.	PROPN
dti-1335	205	6	,	,	PUNCT
dti-1335	205	7	8:45–62	8:45–62	NUM
dti-1335	205	8	.	.	PUNCT
dti-1335	206	1	conover	conover	PROPN
dti-1335	206	2	,	,	PUNCT
dti-1335	206	3	c.a	c.a	PROPN
dti-1335	206	4	.	.	PROPN
dti-1335	206	5	,	,	PUNCT
dti-1335	206	6	kiefer	kiefer	PROPN
dti-1335	206	7	,	,	PUNCT
dti-1335	206	8	m.c	m.c	PROPN
dti-1335	206	9	.	.	PROPN
dti-1335	206	10	and	and	CCONJ
dti-1335	206	11	zapf	zapf	NOUN
dti-1335	206	12	,	,	PUNCT
dti-1335	206	13	j.	j.	PROPN
dti-1335	206	14	1993	1993	NUM
dti-1335	206	15	.	.	PUNCT
dti-1335	207	1	posttransitional	posttransitional	ADJ
dti-1335	207	2	regulation	regulation	NOUN
dti-1335	207	3	of	of	ADP
dti-1335	207	4	insulin	insulin	NOUN
dti-1335	207	5	-	-	PUNCT
dti-1335	207	6	like	like	ADJ
dti-1335	207	7	growth	growth	NOUN
dti-1335	207	8	factor	factor	NOUN
dti-1335	207	9	binding	bind	VERB
dti-1335	207	10	protein-4	protein-4	PROPN
dti-1335	207	11	in	in	ADP
dti-1335	207	12	normal	normal	ADJ
dti-1335	207	13	and	and	CCONJ
dti-1335	207	14	transformed	transform	VERB
dti-1335	207	15	human	human	ADJ
dti-1335	207	16	fi	fi	NOUN
dti-1335	207	17	broblasts	broblast	NOUN
dti-1335	207	18	.	.	PUNCT
dti-1335	208	1	insulin	insulin	NOUN
dti-1335	208	2	-	-	PUNCT
dti-1335	208	3	like	like	ADJ
dti-1335	208	4	growth	growth	NOUN
dti-1335	208	5	factor	factor	NOUN
dti-1335	208	6	dependence	dependence	NOUN
dti-1335	208	7	and	and	CCONJ
dti-1335	208	8	biological	biological	ADJ
dti-1335	208	9	study	study	NOUN
dti-1335	208	10	.	.	PUNCT
dti-1335	209	1	j.	j.	PROPN
dti-1335	209	2	clin	clin	PROPN
dti-1335	209	3	.	.	PUNCT
dti-1335	210	1	endocrinol	endocrinol	NOUN
dti-1335	210	2	.	.	PUNCT
dti-1335	211	1	metab	metab	PROPN
dti-1335	211	2	.	.	PUNCT
dti-1335	211	3	,	,	PUNCT
dti-1335	211	4	91:1129–37	91:1129–37	NOUN
dti-1335	211	5	.	.	PUNCT
dti-1335	211	6	de	de	PROPN
dti-1335	211	7	keyser	keyser	PROPN
dti-1335	211	8	,	,	PUNCT
dti-1335	211	9	j.	j.	PROPN
dti-1335	211	10	,	,	PUNCT
dti-1335	211	11	wilczak	wilczak	PROPN
dti-1335	211	12	,	,	PUNCT
dti-1335	211	13	n.	n.	NOUN
dti-1335	211	14	,	,	PUNCT
dti-1335	211	15	de	de	NOUN
dti-1335	211	16	backer	backer	NOUN
dti-1335	211	17	,	,	PUNCT
dti-1335	211	18	j.p	j.p	PROPN
dti-1335	211	19	.	.	PROPN
dti-1335	211	20	et	et	PROPN
dti-1335	211	21	al	al	PROPN
dti-1335	211	22	.	.	PROPN
dti-1335	211	23	1994a	1994a	NUM
dti-1335	211	24	.	.	PUNCT
dti-1335	212	1	insulin	insulin	NOUN
dti-1335	212	2	-	-	PUNCT
dti-1335	212	3	like	like	ADJ
dti-1335	212	4	growth	growth	NOUN
dti-1335	212	5	factor	factor	NOUN
dti-1335	212	6	-	-	PUNCT
dti-1335	212	7	i	i	PRON
dti-1335	212	8	receptors	receptor	NOUN
dti-1335	212	9	in	in	ADP
dti-1335	212	10	human	human	ADJ
dti-1335	212	11	brain	brain	NOUN
dti-1335	212	12	and	and	CCONJ
dti-1335	212	13	pituitary	pituitary	ADJ
dti-1335	212	14	gland	gland	NOUN
dti-1335	212	15	:	:	PUNCT
dti-1335	212	16	an	an	DET
dti-1335	212	17	autoradiographic	autoradiographic	ADJ
dti-1335	212	18	study	study	NOUN
dti-1335	212	19	.	.	PUNCT
dti-1335	213	1	synapse	synapse	NOUN
dti-1335	213	2	,	,	PUNCT
dti-1335	213	3	17:196–202	17:196–202	PROPN
dti-1335	213	4	.	.	PUNCT
dti-1335	214	1	de	de	PROPN
dti-1335	214	2	keyser	keyser	PROPN
dti-1335	214	3	,	,	PUNCT
dti-1335	214	4	j.	j.	PROPN
dti-1335	214	5	,	,	PUNCT
dti-1335	214	6	wilczak	wilczak	PROPN
dti-1335	214	7	,	,	PUNCT
dti-1335	214	8	n.	n.	NOUN
dti-1335	214	9	and	and	CCONJ
dti-1335	214	10	goossens	goossen	NOUN
dti-1335	214	11	,	,	PUNCT
dti-1335	214	12	a.	a.	NOUN
dti-1335	214	13	1994b	1994b	NUM
dti-1335	214	14	.	.	PUNCT
dti-1335	215	1	insulin	insulin	NOUN
dti-1335	215	2	-	-	PUNCT
dti-1335	215	3	like	like	ADJ
dti-1335	215	4	growth	growth	NOUN
dti-1335	215	5	factor	factor	NOUN
dti-1335	215	6	-	-	PUNCT
dti-1335	215	7	i	i	PRON
dti-1335	215	8	receptor	receptor	NOUN
dti-1335	215	9	densities	density	NOUN
dti-1335	215	10	in	in	ADP
dti-1335	215	11	human	human	ADJ
dti-1335	215	12	frontal	frontal	ADJ
dti-1335	215	13	cortex	cortex	NOUN
dti-1335	215	14	and	and	CCONJ
dti-1335	215	15	white	white	ADJ
dti-1335	215	16	matter	matter	NOUN
dti-1335	215	17	during	during	ADP
dti-1335	215	18	aging	age	VERB
dti-1335	215	19	,	,	PUNCT
dti-1335	215	20	in	in	ADP
dti-1335	215	21	alzheimer	alzheimer	PROPN
dti-1335	215	22	’s	’s	PART
dti-1335	215	23	de	de	X
dti-1335	215	24	disease	disease	NOUN
dti-1335	215	25	,	,	PUNCT
dti-1335	215	26	and	and	CCONJ
dti-1335	215	27	in	in	ADP
dti-1335	215	28	huntington	huntington	PROPN
dti-1335	215	29	's	's	PART
dti-1335	215	30	disease	disease	NOUN
dti-1335	215	31	.	.	PUNCT
dti-1335	216	1	neurosci	neurosci	PROPN
dti-1335	216	2	.	.	PUNCT
dti-1335	217	1	lett	lett	PROPN
dti-1335	217	2	.	.	PROPN
dti-1335	217	3	,	,	PUNCT
dti-1335	217	4	172:93–6	172:93–6	X
dti-1335	217	5	.	.	PUNCT
dti-1335	218	1	feldman	feldman	PROPN
dti-1335	218	2	,	,	PUNCT
dti-1335	218	3	e.l	e.l	PROPN
dti-1335	218	4	.	.	PROPN
dti-1335	218	5	,	,	PUNCT
dti-1335	218	6	sullivan	sullivan	PROPN
dti-1335	218	7	,	,	PUNCT
dti-1335	218	8	k.a	k.a	PROPN
dti-1335	218	9	.	.	PROPN
dti-1335	218	10	,	,	PUNCT
dti-1335	218	11	kim	kim	PROPN
dti-1335	218	12	,	,	PUNCT
dti-1335	218	13	b.	b.	PROPN
dti-1335	218	14	et	et	PROPN
dti-1335	218	15	al	al	PROPN
dti-1335	218	16	.	.	PROPN
dti-1335	218	17	1997	1997	NUM
dti-1335	218	18	.	.	PUNCT
dti-1335	219	1	insulin	insulin	NOUN
dti-1335	219	2	-	-	PUNCT
dti-1335	219	3	like	like	ADJ
dti-1335	219	4	growth	growth	NOUN
dti-1335	219	5	factors	factor	NOUN
dti-1335	219	6	regulate	regulate	VERB
dti-1335	219	7	neuronal	neuronal	ADJ
dti-1335	219	8	differentiation	differentiation	NOUN
dti-1335	219	9	and	and	CCONJ
dti-1335	219	10	survival	survival	NOUN
dti-1335	219	11	.	.	PUNCT
dti-1335	220	1	neurobiol	neurobiol	PROPN
dti-1335	220	2	.	.	PUNCT
dti-1335	221	1	dis	dis	PROPN
dti-1335	221	2	.	.	PUNCT
dti-1335	221	3	,	,	PUNCT
dti-1335	221	4	4:201–14	4:201–14	PROPN
dti-1335	221	5	.	.	PUNCT
dti-1335	221	6	fillipini	fillipini	PROPN
dti-1335	221	7	,	,	PUNCT
dti-1335	221	8	g.	g.	PROPN
dti-1335	221	9	,	,	PUNCT
dti-1335	221	10	munari	munari	PROPN
dti-1335	221	11	,	,	PUNCT
dti-1335	221	12	l.	l.	PROPN
dti-1335	221	13	,	,	PUNCT
dti-1335	221	14	incorvaia	incorvaia	PROPN
dti-1335	221	15	,	,	PUNCT
dti-1335	221	16	b.	b.	PROPN
dti-1335	221	17	et	et	PROPN
dti-1335	221	18	al	al	PROPN
dti-1335	221	19	.	.	PROPN
dti-1335	221	20	2003	2003	NUM
dti-1335	221	21	.	.	PUNCT
dti-1335	222	1	interferon	interferon	PROPN
dti-1335	222	2	’s	’s	ADV
dti-1335	222	3	in	in	ADP
dti-1335	222	4	relapsing	relapse	VERB
dti-1335	222	5	remitting	remit	VERB
dti-1335	222	6	multiple	multiple	ADJ
dti-1335	222	7	sclerose	sclerose	NOUN
dti-1335	222	8	:	:	PUNCT
dti-1335	222	9	a	a	DET
dti-1335	222	10	systematic	systematic	ADJ
dti-1335	222	11	review	review	NOUN
dti-1335	222	12	.	.	PUNCT
dti-1335	223	1	lancet	lancet	PROPN
dti-1335	223	2	,	,	PUNCT
dti-1335	223	3	361:545–52	361:545–52	NUM
dti-1335	223	4	.	.	PUNCT
dti-1335	224	1	firth	firth	PROPN
dti-1335	224	2	,	,	PUNCT
dti-1335	224	3	s.m	s.m	PROPN
dti-1335	224	4	.	.	PROPN
dti-1335	224	5	and	and	CCONJ
dti-1335	224	6	baxter	baxter	PROPN
dti-1335	224	7	,	,	PUNCT
dti-1335	224	8	r.c	r.c	PROPN
dti-1335	224	9	.	.	PROPN
dti-1335	224	10	2002	2002	NUM
dti-1335	224	11	.	.	PUNCT
dti-1335	225	1	cellular	cellular	ADJ
dti-1335	225	2	actions	action	NOUN
dti-1335	225	3	of	of	ADP
dti-1335	225	4	the	the	DET
dti-1335	225	5	insulin	insulin	NOUN
dti-1335	225	6	-	-	PUNCT
dti-1335	225	7	like	like	ADJ
dti-1335	225	8	growth	growth	NOUN
dti-1335	225	9	factor	factor	NOUN
dti-1335	225	10	binding	bind	VERB
dti-1335	225	11	proteins	protein	NOUN
dti-1335	225	12	.	.	PUNCT
dti-1335	226	1	endocr	endocr	PROPN
dti-1335	226	2	.	.	PUNCT
dti-1335	227	1	rev	rev	PROPN
dti-1335	227	2	.	.	PROPN
dti-1335	227	3	,	,	PUNCT
dti-1335	227	4	23:824–54	23:824–54	NUM
dti-1335	227	5	.	.	PUNCT
dti-1335	228	1	frank	frank	PROPN
dti-1335	228	2	,	,	PUNCT
dti-1335	228	3	j.a	j.a	PROPN
dti-1335	228	4	.	.	PROPN
dti-1335	228	5	,	,	PUNCT
dti-1335	228	6	richert	richert	PROPN
dti-1335	228	7	,	,	PUNCT
dti-1335	228	8	n.	n.	PROPN
dti-1335	228	9	,	,	PUNCT
dti-1335	228	10	lewis	lewis	PROPN
dti-1335	228	11	,	,	PUNCT
dti-1335	228	12	b.	b.	PROPN
dti-1335	228	13	et	et	PROPN
dti-1335	228	14	al	al	PROPN
dti-1335	228	15	.	.	PROPN
dti-1335	228	16	2002	2002	NUM
dti-1335	228	17	.	.	PUNCT
dti-1335	229	1	a	a	DET
dti-1335	229	2	pilot	pilot	NOUN
dti-1335	229	3	study	study	NOUN
dti-1335	229	4	of	of	ADP
dti-1335	229	5	recombinant	recombinant	ADJ
dti-1335	229	6	insulin	insulin	NOUN
dti-1335	229	7	-	-	PUNCT
dti-1335	229	8	like	like	ADJ
dti-1335	229	9	growth	growth	NOUN
dti-1335	229	10	factor-1	factor-1	NUM
dti-1335	229	11	in	in	ADP
dti-1335	229	12	seven	seven	NUM
dti-1335	229	13	multiple	multiple	ADJ
dti-1335	229	14	sclerosis	sclerosis	NOUN
dti-1335	229	15	patients	patient	NOUN
dti-1335	229	16	.	.	PUNCT
dti-1335	230	1	mult	mult	PROPN
dti-1335	230	2	.	.	PROPN
dti-1335	230	3	scler	scler	PROPN
dti-1335	230	4	.	.	PUNCT
dti-1335	230	5	,	,	PUNCT
dti-1335	230	6	8:24–9	8:24–9	NUM
dti-1335	230	7	.	.	PUNCT
dti-1335	231	1	kermer	kermer	PROPN
dti-1335	231	2	,	,	PUNCT
dti-1335	231	3	p.	p.	NOUN
dti-1335	231	4	,	,	PUNCT
dti-1335	231	5	klocker	klocker	NOUN
dti-1335	231	6	,	,	PUNCT
dti-1335	231	7	n.	n.	NOUN
dti-1335	231	8	,	,	PUNCT
dti-1335	231	9	labes	labe	NOUN
dti-1335	231	10	,	,	PUNCT
dti-1335	231	11	m.	m.	NOUN
dti-1335	231	12	et	et	PROPN
dti-1335	231	13	al	al	PROPN
dti-1335	231	14	.	.	PROPN
dti-1335	231	15	2000	2000	NUM
dti-1335	231	16	.	.	PUNCT
dti-1335	232	1	insulin	insulin	NOUN
dti-1335	232	2	-	-	PUNCT
dti-1335	232	3	like	like	ADJ
dti-1335	232	4	growth	growth	NOUN
dti-1335	232	5	factor	factor	NOUN
dti-1335	232	6	-	-	PUNCT
dti-1335	232	7	i	i	PRON
dti-1335	232	8	protects	protect	VERB
dti-1335	232	9	axotomised	axotomise	VERB
dti-1335	232	10	rat	rat	NOUN
dti-1335	232	11	retinal	retinal	ADJ
dti-1335	232	12	ganglion	ganglion	NOUN
dti-1335	232	13	cells	cell	NOUN
dti-1335	232	14	from	from	ADP
dti-1335	232	15	secondary	secondary	ADJ
dti-1335	232	16	death	death	NOUN
dti-1335	232	17	via	via	ADP
dti-1335	232	18	pi3	pi3	NOUN
dti-1335	232	19	-	-	PUNCT
dti-1335	232	20	k	k	NOUN
dti-1335	232	21	-	-	ADJ
dti-1335	232	22	dependent	dependent	ADJ
dti-1335	232	23	akt	akt	PROPN
dti-1335	232	24	phosphorylation	phosphorylation	NOUN
dti-1335	232	25	and	and	CCONJ
dti-1335	232	26	inhibition	inhibition	NOUN
dti-1335	232	27	of	of	ADP
dti-1335	232	28	caspase3	caspase3	NOUN
dti-1335	232	29	in	in	ADP
dti-1335	232	30	vivo	vivo	NOUN
dti-1335	232	31	.	.	PUNCT
dti-1335	233	1	j.	j.	PROPN
dti-1335	233	2	neurosci	neurosci	PROPN
dti-1335	233	3	.	.	PROPN
dti-1335	233	4	,	,	PUNCT
dti-1335	233	5	20:2–8	20:2–8	NUM
dti-1335	233	6	.	.	PUNCT
dti-1335	234	1	kim	kim	PROPN
dti-1335	234	2	,	,	PUNCT
dti-1335	234	3	b.	b.	PROPN
dti-1335	234	4	,	,	PUNCT
dti-1335	234	5	leventhal	leventhal	PROPN
dti-1335	234	6	,	,	PUNCT
dti-1335	234	7	p.s	p.s	PROPN
dti-1335	234	8	.	.	PROPN
dti-1335	234	9	,	,	PUNCT
dti-1335	234	10	saltiel	saltiel	PROPN
dti-1335	234	11	,	,	PUNCT
dti-1335	234	12	a.r	a.r	PROPN
dti-1335	234	13	.	.	PROPN
dti-1335	234	14	et	et	PROPN
dti-1335	234	15	al	al	PROPN
dti-1335	234	16	.	.	PROPN
dti-1335	234	17	1997	1997	NUM
dti-1335	234	18	.	.	PUNCT
dti-1335	235	1	insulin	insulin	NOUN
dti-1335	235	2	-	-	PUNCT
dti-1335	235	3	like	like	ADJ
dti-1335	235	4	growth	growth	NOUN
dti-1335	235	5	factor	factor	NOUN
dti-1335	235	6	-	-	PUNCT
dti-1335	235	7	i	i	PRON
dti-1335	235	8	mediated	mediate	VERB
dti-1335	235	9	neurite	neurite	NOUN
dti-1335	235	10	outgrowth	outgrowth	NOUN
dti-1335	235	11	in	in	ADP
dti-1335	235	12	vitro	vitro	X
dti-1335	235	13	requires	require	VERB
dti-1335	235	14	mitogen	mitogen	NOUN
dti-1335	235	15	-	-	PUNCT
dti-1335	235	16	activated	activate	VERB
dti-1335	235	17	protein	protein	NOUN
dti-1335	235	18	kinase	kinase	NOUN
dti-1335	235	19	activation	activation	NOUN
dti-1335	235	20	.	.	PUNCT
dti-1335	236	1	j.	j.	PROPN
dti-1335	236	2	biol	biol	PROPN
dti-1335	236	3	.	.	PUNCT
dti-1335	237	1	chem	chem	PROPN
dti-1335	237	2	.	.	PUNCT
dti-1335	237	3	,	,	PUNCT
dti-1335	238	1	272:21268–73	272:21268–73	PROPN
dti-1335	238	2	.	.	PUNCT
dti-1335	238	3	kornfeld	kornfeld	PROPN
dti-1335	238	4	,	,	PUNCT
dti-1335	238	5	s.	s.	PROPN
dti-1335	238	6	1992	1992	NUM
dti-1335	238	7	.	.	PUNCT
dti-1335	239	1	structure	structure	NOUN
dti-1335	239	2	and	and	CCONJ
dti-1335	239	3	function	function	NOUN
dti-1335	239	4	of	of	ADP
dti-1335	239	5	the	the	DET
dti-1335	239	6	mannose-6	mannose-6	PROPN
dti-1335	239	7	-	-	PUNCT
dti-1335	239	8	phosphate/	phosphate/	ADV
dti-1335	239	9	insulin	insulin	NOUN
dti-1335	239	10	-	-	PUNCT
dti-1335	239	11	like	like	ADJ
dti-1335	239	12	growth	growth	NOUN
dti-1335	239	13	factor	factor	NOUN
dti-1335	239	14	-	-	PUNCT
dti-1335	239	15	ii	ii	NOUN
dti-1335	239	16	receptors	receptor	NOUN
dti-1335	239	17	.	.	PUNCT
dti-1335	240	1	ann	ann	AUX
dti-1335	240	2	.	.	PUNCT
dti-1335	240	3	rev	rev	PROPN
dti-1335	240	4	.	.	PROPN
dti-1335	240	5	biochem	biochem	PROPN
dti-1335	240	6	.	.	PUNCT
dti-1335	240	7	,	,	PUNCT
dti-1335	240	8	61:307–30	61:307–30	PROPN
dti-1335	240	9	.	.	PUNCT
dti-1335	241	1	kühl	kühl	PROPN
dti-1335	241	2	,	,	PUNCT
dti-1335	241	3	n.m	n.m	PROPN
dti-1335	241	4	.	.	PROPN
dti-1335	241	5	,	,	PUNCT
dti-1335	241	6	de	de	PROPN
dti-1335	241	7	keyser	keyser	PROPN
dti-1335	241	8	,	,	PUNCT
dti-1335	241	9	j.	j.	PROPN
dti-1335	241	10	,	,	PUNCT
dti-1335	241	11	de	de	PROPN
dti-1335	241	12	vries	vries	PROPN
dti-1335	241	13	,	,	PUNCT
dti-1335	241	14	h.	h.	PROPN
dti-1335	241	15	et	et	PROPN
dti-1335	241	16	al	al	PROPN
dti-1335	241	17	.	.	PROPN
dti-1335	241	18	2002	2002	NUM
dti-1335	241	19	.	.	PUNCT
dti-1335	242	1	insulin	insulin	NOUN
dti-1335	242	2	-	-	PUNCT
dti-1335	242	3	like	like	ADJ
dti-1335	242	4	growth	growth	NOUN
dti-1335	242	5	factor	factor	NOUN
dti-1335	242	6	binding	bind	VERB
dti-1335	242	7	protein-1	protein-1	PROPN
dti-1335	242	8	and	and	CCONJ
dti-1335	242	9	-2	-2	NOUN
dti-1335	242	10	differentially	differentially	ADV
dti-1335	242	11	inhibit	inhibit	VERB
dti-1335	242	12	rat	rat	NOUN
dti-1335	242	13	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	242	14	precursor	precursor	NOUN
dti-1335	242	15	survival	survival	NOUN
dti-1335	242	16	and	and	CCONJ
dti-1335	242	17	differentiation	differentiation	NOUN
dti-1335	242	18	in	in	ADP
dti-1335	242	19	vitro	vitro	X
dti-1335	242	20	.	.	PUNCT
dti-1335	243	1	j.	j.	PROPN
dti-1335	243	2	neurosci	neurosci	PROPN
dti-1335	243	3	.	.	PROPN
dti-1335	243	4	,	,	PUNCT
dti-1335	243	5	69:207–16	69:207–16	PROPN
dti-1335	243	6	.	.	PUNCT
dti-1335	244	1	kühl	kühl	PROPN
dti-1335	244	2	,	,	PUNCT
dti-1335	244	3	n.m	n.m	PROPN
dti-1335	244	4	.	.	PROPN
dti-1335	244	5	,	,	PUNCT
dti-1335	244	6	hoekstra	hoekstra	PROPN
dti-1335	244	7	,	,	PUNCT
dti-1335	244	8	d.	d.	PROPN
dti-1335	244	9	,	,	PUNCT
dti-1335	244	10	de	de	PROPN
dti-1335	244	11	vries	vries	PROPN
dti-1335	244	12	,	,	PUNCT
dti-1335	244	13	h.	h.	PROPN
dti-1335	244	14	et	et	PROPN
dti-1335	244	15	al	al	PROPN
dti-1335	244	16	.	.	PROPN
dti-1335	244	17	2003	2003	NUM
dti-1335	244	18	.	.	PUNCT
dti-1335	245	1	insulin	insulin	NOUN
dti-1335	245	2	-	-	PUNCT
dti-1335	245	3	like	like	ADJ
dti-1335	245	4	growth	growth	NOUN
dti-1335	245	5	factor	factor	NOUN
dti-1335	245	6	binding	bind	VERB
dti-1335	245	7	protein-6	protein-6	PROPN
dti-1335	245	8	inhibits	inhibit	VERB
dti-1335	245	9	survival	survival	NOUN
dti-1335	245	10	and	and	CCONJ
dti-1335	245	11	differentiation	differentiation	NOUN
dti-1335	245	12	of	of	ADP
dti-1335	245	13	rat	rat	NOUN
dti-1335	245	14	oilgodendrocyte	oilgodendrocyte	ADJ
dti-1335	245	15	precursor	precursor	NOUN
dti-1335	245	16	cells	cell	NOUN
dti-1335	245	17	.	.	PUNCT
dti-1335	246	1	glia	glia	PROPN
dti-1335	246	2	,	,	PUNCT
dti-1335	246	3	44:91–101	44:91–101	NUM
dti-1335	246	4	.	.	PUNCT
dti-1335	247	1	leroith	leroith	PROPN
dti-1335	247	2	,	,	PUNCT
dti-1335	247	3	d.	d.	PROPN
dti-1335	247	4	,	,	PUNCT
dti-1335	247	5	werner	werner	PROPN
dti-1335	247	6	,	,	PUNCT
dti-1335	247	7	h.	h.	PROPN
dti-1335	247	8	,	,	PUNCT
dti-1335	247	9	beitner	beitner	PROPN
dti-1335	247	10	-	-	PUNCT
dti-1335	247	11	johnson	johnson	PROPN
dti-1335	247	12	,	,	PUNCT
dti-1335	247	13	d.	d.	PROPN
dti-1335	247	14	et	et	PROPN
dti-1335	247	15	al	al	PROPN
dti-1335	247	16	.	.	PROPN
dti-1335	247	17	1995	1995	NUM
dti-1335	247	18	.	.	PUNCT
dti-1335	248	1	molecular	molecular	ADJ
dti-1335	248	2	and	and	CCONJ
dti-1335	248	3	cellular	cellular	ADJ
dti-1335	248	4	aspects	aspect	NOUN
dti-1335	248	5	of	of	ADP
dti-1335	248	6	the	the	DET
dti-1335	248	7	insulin	insulin	NOUN
dti-1335	248	8	-	-	PUNCT
dti-1335	248	9	like	like	ADJ
dti-1335	248	10	growth	growth	NOUN
dti-1335	248	11	factor	factor	NOUN
dti-1335	248	12	i	i	PRON
dti-1335	248	13	receptor	receptor	VERB
dti-1335	248	14	.	.	PUNCT
dti-1335	249	1	endocr	endocr	PROPN
dti-1335	249	2	.	.	PUNCT
dti-1335	250	1	rev	rev	PROPN
dti-1335	250	2	.	.	PROPN
dti-1335	250	3	,	,	PUNCT
dti-1335	250	4	16:143–63	16:143–63	NOUN
dti-1335	250	5	.	.	PUNCT
dti-1335	251	1	liu	liu	PROPN
dti-1335	251	2	,	,	PUNCT
dti-1335	251	3	j.p	j.p	PROPN
dti-1335	251	4	.	.	PROPN
dti-1335	251	5	,	,	PUNCT
dti-1335	251	6	baker	baker	PROPN
dti-1335	251	7	,	,	PUNCT
dti-1335	251	8	j.	j.	PROPN
dti-1335	251	9	,	,	PUNCT
dti-1335	251	10	perkins	perkins	PROPN
dti-1335	251	11	,	,	PUNCT
dti-1335	251	12	a.s	a.s	PROPN
dti-1335	251	13	.	.	PROPN
dti-1335	251	14	et	et	PROPN
dti-1335	251	15	al	al	PROPN
dti-1335	251	16	.	.	PROPN
dti-1335	251	17	1993	1993	NUM
dti-1335	251	18	.	.	PUNCT
dti-1335	252	1	mice	mouse	NOUN
dti-1335	252	2	carrying	carry	VERB
dti-1335	252	3	null	null	ADJ
dti-1335	252	4	mutations	mutation	NOUN
dti-1335	252	5	of	of	ADP
dti-1335	252	6	the	the	DET
dti-1335	252	7	genes	gene	NOUN
dti-1335	252	8	encoding	encode	VERB
dti-1335	252	9	insulin	insulin	NOUN
dti-1335	252	10	-	-	PUNCT
dti-1335	252	11	like	like	ADJ
dti-1335	252	12	growth	growth	NOUN
dti-1335	252	13	factor	factor	NOUN
dti-1335	252	14	i	i	PRON
dti-1335	252	15	(	(	PUNCT
dti-1335	252	16	igf-1	igf-1	NOUN
dti-1335	252	17	)	)	PUNCT
dti-1335	252	18	and	and	CCONJ
dti-1335	252	19	type	type	NOUN
dti-1335	252	20	1	1	NUM
dti-1335	252	21	igf	igf	NOUN
dti-1335	252	22	receptor	receptor	NOUN
dti-1335	252	23	(	(	PUNCT
dti-1335	252	24	igf-1r	igf-1r	PROPN
dti-1335	252	25	)	)	PUNCT
dti-1335	252	26	.	.	PUNCT
dti-1335	253	1	cell	cell	NOUN
dti-1335	253	2	,	,	PUNCT
dti-1335	253	3	75:59–72	75:59–72	PROPN
dti-1335	253	4	.	.	PUNCT
dti-1335	254	1	liu	liu	PROPN
dti-1335	254	2	,	,	PUNCT
dti-1335	254	3	x.	x.	NOUN
dti-1335	254	4	and	and	CCONJ
dti-1335	254	5	yao	yao	PROPN
dti-1335	254	6	,	,	PUNCT
dti-1335	254	7	d.l	d.l	PROPN
dti-1335	254	8	.	.	PROPN
dti-1335	254	9	1995	1995	NUM
dti-1335	254	10	.	.	PUNCT
dti-1335	255	1	insulin	insulin	NOUN
dti-1335	255	2	-	-	PUNCT
dti-1335	255	3	like	like	ADJ
dti-1335	255	4	growth	growth	NOUN
dti-1335	255	5	factor	factor	NOUN
dti-1335	255	6	-	-	PUNCT
dti-1335	255	7	i	i	PRON
dti-1335	255	8	treatment	treatment	NOUN
dti-1335	255	9	reduces	reduce	VERB
dti-1335	255	10	clinical	clinical	ADJ
dti-1335	255	11	defi	defi	NOUN
dti-1335	255	12	cits	cit	NOUN
dti-1335	255	13	and	and	CCONJ
dti-1335	255	14	plaques	plaque	NOUN
dti-1335	255	15	severity	severity	NOUN
dti-1335	255	16	in	in	ADP
dti-1335	255	17	acute	acute	ADJ
dti-1335	255	18	demyelinating	demyelinate	VERB
dti-1335	255	19	experimental	experimental	ADJ
dti-1335	255	20	autoimmune	autoimmune	ADJ
dti-1335	255	21	encephalitis	encephalitis	NOUN
dti-1335	255	22	.	.	PUNCT
dti-1335	256	1	mult	mult	PROPN
dti-1335	256	2	.	.	PROPN
dti-1335	256	3	scler	scler	PROPN
dti-1335	256	4	.	.	PUNCT
dti-1335	256	5	,	,	PUNCT
dti-1335	256	6	1:2–9	1:2–9	NUM
dti-1335	256	7	.	.	PUNCT
dti-1335	257	1	liu	liu	PROPN
dti-1335	257	2	,	,	PUNCT
dti-1335	257	3	x.j	x.j	PROPN
dti-1335	257	4	.	.	PROPN
dti-1335	257	5	,	,	PUNCT
dti-1335	257	6	xie	xie	PROPN
dti-1335	257	7	,	,	PUNCT
dti-1335	257	8	q.	q.	PROPN
dti-1335	257	9	,	,	PUNCT
dti-1335	257	10	zhu	zhu	PROPN
dti-1335	257	11	,	,	PUNCT
dti-1335	257	12	y.f	y.f	PROPN
dti-1335	257	13	.	.	PROPN
dti-1335	257	14	et	et	PROPN
dti-1335	257	15	al	al	PROPN
dti-1335	257	16	.	.	PROPN
dti-1335	257	17	2001	2001	NUM
dti-1335	257	18	.	.	PUNCT
dti-1335	258	1	identifi	identifi	PROPN
dti-1335	258	2	cation	cation	NOUN
dti-1335	258	3	of	of	ADP
dti-1335	258	4	a	a	DET
dti-1335	258	5	nonpeptide	nonpeptide	NOUN
dti-1335	258	6	ligand	ligand	NOUN
dti-1335	258	7	that	that	PRON
dti-1335	258	8	release	release	VERB
dti-1335	258	9	bioactive	bioactive	ADJ
dti-1335	258	10	insulin	insulin	NOUN
dti-1335	258	11	-	-	PUNCT
dti-1335	258	12	like	like	ADJ
dti-1335	258	13	growth	growth	NOUN
dti-1335	258	14	factor	factor	NOUN
dti-1335	258	15	-	-	PUNCT
dti-1335	258	16	i	i	NOUN
dti-1335	258	17	from	from	ADP
dti-1335	258	18	its	its	PRON
dti-1335	258	19	binding	bind	VERB
dti-1335	258	20	protein	protein	NOUN
dti-1335	258	21	complex	complex	NOUN
dti-1335	258	22	.	.	PUNCT
dti-1335	259	1	j.	j.	PROPN
dti-1335	259	2	biol	biol	PROPN
dti-1335	259	3	.	.	PUNCT
dti-1335	260	1	chem	chem	PROPN
dti-1335	260	2	.	.	PUNCT
dti-1335	260	3	,	,	PUNCT
dti-1335	261	1	276:32419–22	276:32419–22	NUM
dti-1335	261	2	.	.	PUNCT
dti-1335	262	1	loddick	loddick	PROPN
dti-1335	262	2	,	,	PUNCT
dti-1335	262	3	s.a	s.a	PROPN
dti-1335	262	4	.	.	PROPN
dti-1335	262	5	,	,	PUNCT
dti-1335	262	6	liu	liu	PROPN
dti-1335	262	7	,	,	PUNCT
dti-1335	262	8	x.j	x.j	PROPN
dti-1335	262	9	.	.	PROPN
dti-1335	262	10	,	,	PUNCT
dti-1335	262	11	lu	lu	PROPN
dti-1335	262	12	,	,	PUNCT
dti-1335	262	13	z.x	z.x	PROPN
dti-1335	262	14	.	.	PROPN
dti-1335	262	15	et	et	PROPN
dti-1335	262	16	al	al	PROPN
dti-1335	262	17	.	.	PROPN
dti-1335	262	18	1998	1998	NUM
dti-1335	262	19	.	.	PUNCT
dti-1335	263	1	displacement	displacement	NOUN
dti-1335	263	2	of	of	ADP
dti-1335	263	3	insulin	insulin	NOUN
dti-1335	263	4	-	-	PUNCT
dti-1335	263	5	like	like	ADJ
dti-1335	263	6	growth	growth	NOUN
dti-1335	263	7	factors	factor	NOUN
dti-1335	263	8	from	from	ADP
dti-1335	263	9	their	their	PRON
dti-1335	263	10	binding	bind	VERB
dti-1335	263	11	proteins	protein	NOUN
dti-1335	263	12	as	as	ADP
dti-1335	263	13	a	a	DET
dti-1335	263	14	potential	potential	ADJ
dti-1335	263	15	treatment	treatment	NOUN
dti-1335	263	16	for	for	ADP
dti-1335	263	17	stroke	stroke	NOUN
dti-1335	263	18	.	.	PUNCT
dti-1335	264	1	proc	proc	PROPN
dti-1335	264	2	.	.	PUNCT
dti-1335	265	1	natl	natl	PROPN
dti-1335	265	2	.	.	PUNCT
dti-1335	266	1	acad	acad	PROPN
dti-1335	266	2	.	.	PUNCT
dti-1335	267	1	sci	sci	PROPN
dti-1335	267	2	.	.	PROPN
dti-1335	267	3	,	,	PUNCT
dti-1335	267	4	u.s.a	u.s.a	PROPN
dti-1335	267	5	.	.	PROPN
dti-1335	267	6	,	,	PUNCT
dti-1335	267	7	95:1894–8	95:1894–8	X
dti-1335	267	8	.	.	NUM
dti-1335	267	9	logan	logan	PROPN
dti-1335	267	10	,	,	PUNCT
dti-1335	267	11	a.	a.	PROPN
dti-1335	267	12	,	,	PUNCT
dti-1335	267	13	gonzalez	gonzalez	PROPN
dti-1335	267	14	,	,	PUNCT
dti-1335	267	15	a.m.	a.m.	ADV
dti-1335	267	16	,	,	PUNCT
dti-1335	267	17	hill	hill	PROPN
dti-1335	267	18	,	,	PUNCT
dti-1335	267	19	d.	d.	PROPN
dti-1335	267	20	et	et	PROPN
dti-1335	267	21	al	al	PROPN
dti-1335	267	22	.	.	PROPN
dti-1335	267	23	1994	1994	NUM
dti-1335	267	24	.	.	PUNCT
dti-1335	267	25	coordinated	coordinate	VERB
dti-1335	267	26	pattern	pattern	NOUN
dti-1335	267	27	of	of	ADP
dti-1335	267	28	expression	expression	NOUN
dti-1335	267	29	and	and	CCONJ
dti-1335	267	30	localization	localization	NOUN
dti-1335	267	31	of	of	ADP
dti-1335	267	32	insulin	insulin	NOUN
dti-1335	267	33	-	-	PUNCT
dti-1335	267	34	like	like	ADJ
dti-1335	267	35	growth	growth	NOUN
dti-1335	267	36	factor	factor	NOUN
dti-1335	267	37	-	-	PUNCT
dti-1335	267	38	ii	ii	PROPN
dti-1335	267	39	(	(	PUNCT
dti-1335	267	40	igf	igf	PROPN
dti-1335	267	41	-	-	PUNCT
dti-1335	267	42	ii	ii	NOUN
dti-1335	267	43	)	)	PUNCT
dti-1335	267	44	and	and	CCONJ
dti-1335	267	45	igf	igf	PROPN
dti-1335	267	46	-	-	ADJ
dti-1335	267	47	binding	binding	ADJ
dti-1335	267	48	protein-2	protein-2	NOUN
dti-1335	267	49	in	in	ADP
dti-1335	267	50	the	the	DET
dti-1335	267	51	adult	adult	NOUN
dti-1335	267	52	brain	brain	NOUN
dti-1335	267	53	.	.	PUNCT
dti-1335	268	1	endocrinology	endocrinology	NOUN
dti-1335	268	2	,	,	PUNCT
dti-1335	268	3	135:2255–64	135:2255–64	PROPN
dti-1335	268	4	.	.	PUNCT
dti-1335	269	1	lovett	lovett	PROPN
dti-1335	269	2	-	-	PUNCT
dti-1335	269	3	racke	racke	PROPN
dti-1335	269	4	,	,	PUNCT
dti-1335	269	5	a.e	a.e	PROPN
dti-1335	269	6	.	.	PROPN
dti-1335	269	7	,	,	PUNCT
dti-1335	269	8	bittner	bittner	PROPN
dti-1335	269	9	,	,	PUNCT
dti-1335	269	10	p.	p.	NOUN
dti-1335	269	11	and	and	CCONJ
dti-1335	269	12	cross	cross	PROPN
dti-1335	269	13	,	,	PUNCT
dti-1335	269	14	a.h	a.h	PROPN
dti-1335	269	15	.	.	PROPN
dti-1335	269	16	1998	1998	NUM
dti-1335	269	17	.	.	PUNCT
dti-1335	270	1	regulation	regulation	NOUN
dti-1335	270	2	of	of	ADP
dti-1335	270	3	experimental	experimental	ADJ
dti-1335	270	4	autoimmune	autoimmune	ADJ
dti-1335	270	5	enceplamyelitis	enceplamyelitis	PROPN
dti-1335	270	6	with	with	ADP
dti-1335	270	7	insulin	insulin	NOUN
dti-1335	270	8	-	-	PUNCT
dti-1335	270	9	like	like	ADJ
dti-1335	270	10	growth	growth	NOUN
dti-1335	270	11	factor	factor	NOUN
dti-1335	270	12	(	(	PUNCT
dti-1335	270	13	igf	igf	PROPN
dti-1335	270	14	-	-	PROPN
dti-1335	270	15	i	i	PROPN
dti-1335	270	16	)	)	PUNCT
dti-1335	270	17	and	and	CCONJ
dti-1335	270	18	igf	igf	PROPN
dti-1335	270	19	-	-	PROPN
dti-1335	270	20	i	i	PROPN
dti-1335	270	21	/	/	SYM
dti-1335	270	22	igf	igf	NOUN
dti-1335	270	23	-	-	ADJ
dti-1335	270	24	binding	bind	VERB
dti-1335	270	25	protein-3	protein-3	NOUN
dti-1335	270	26	complex	complex	ADJ
dti-1335	270	27	(	(	PUNCT
dti-1335	270	28	igf	igf	NOUN
dti-1335	270	29	-	-	ADJ
dti-1335	270	30	i/	i/	PRON
dti-1335	270	31	igfbp-3	igfbp-3	NUM
dti-1335	270	32	)	)	PUNCT
dti-1335	270	33	.	.	PUNCT
dti-1335	271	1	j.	j.	PROPN
dti-1335	271	2	clin	clin	PROPN
dti-1335	271	3	.	.	PUNCT
dti-1335	272	1	invest	invest	PROPN
dti-1335	272	2	.	.	PUNCT
dti-1335	272	3	,	,	PUNCT
dti-1335	272	4	101:1797–804	101:1797–804	NUM
dti-1335	272	5	.	.	PUNCT
dti-1335	273	1	mackay	mackay	PROPN
dti-1335	273	2	,	,	PUNCT
dti-1335	273	3	k.b	k.b	PROPN
dti-1335	273	4	.	.	PROPN
dti-1335	273	5	,	,	PUNCT
dti-1335	273	6	loddick	loddick	PROPN
dti-1335	273	7	,	,	PUNCT
dti-1335	273	8	s.a	s.a	PROPN
dti-1335	273	9	.	.	PROPN
dti-1335	273	10	,	,	PUNCT
dti-1335	273	11	naeve	naeve	NOUN
dti-1335	273	12	,	,	PUNCT
dti-1335	273	13	g.s	g.s	PROPN
dti-1335	273	14	.	.	PROPN
dti-1335	273	15	et	et	PROPN
dti-1335	273	16	al	al	PROPN
dti-1335	273	17	.	.	PROPN
dti-1335	273	18	2003	2003	NUM
dti-1335	273	19	.	.	PUNCT
dti-1335	274	1	neuroprotective	neuroprotective	ADJ
dti-1335	274	2	effects	effect	NOUN
dti-1335	274	3	of	of	ADP
dti-1335	274	4	insulin	insulin	NOUN
dti-1335	274	5	-	-	PUNCT
dti-1335	274	6	like	like	ADJ
dti-1335	274	7	growth	growth	NOUN
dti-1335	274	8	factor	factor	NOUN
dti-1335	274	9	-	-	PUNCT
dti-1335	274	10	binding	bind	VERB
dti-1335	274	11	protein	protein	NOUN
dti-1335	274	12	ligand	ligand	NOUN
dti-1335	274	13	inhibitors	inhibitor	NOUN
dti-1335	274	14	in	in	ADP
dti-1335	274	15	vitro	vitro	X
dti-1335	274	16	and	and	CCONJ
dti-1335	274	17	in	in	ADP
dti-1335	274	18	vivo	vivo	NOUN
dti-1335	274	19	.	.	PUNCT
dti-1335	275	1	j.	j.	PROPN
dti-1335	275	2	cereb	cereb	PROPN
dti-1335	275	3	.	.	PUNCT
dti-1335	275	4	blood	blood	NOUN
dti-1335	275	5	flow	flow	NOUN
dti-1335	275	6	metab	metab	NOUN
dti-1335	275	7	.	.	PUNCT
dti-1335	275	8	,	,	PUNCT
dti-1335	275	9	23:1160–7	23:1160–7	NUM
dti-1335	275	10	.	.	NOUN
dti-1335	275	11	44	44	NUM
dti-1335	275	12	wilczak	wilczak	NOUN
dti-1335	275	13	et	et	NOUN
dti-1335	275	14	al	al	PROPN
dti-1335	275	15	drug	drug	PROPN
dti-1335	275	16	target	target	NOUN
dti-1335	275	17	insights	insight	NOUN
dti-1335	275	18	2008:3	2008:3	NUM
dti-1335	275	19	mason	mason	PROPN
dti-1335	275	20	,	,	PUNCT
dti-1335	275	21	j.l	j.l	PROPN
dti-1335	275	22	.	.	PROPN
dti-1335	275	23	,	,	PUNCT
dti-1335	275	24	xuan	xuan	PROPN
dti-1335	275	25	,	,	PUNCT
dti-1335	275	26	s.	s.	PROPN
dti-1335	275	27	and	and	CCONJ
dti-1335	275	28	dragatsis	dragatsis	PROPN
dti-1335	275	29	,	,	PUNCT
dti-1335	275	30	i.	i.	PROPN
dti-1335	275	31	2003	2003	NUM
dti-1335	275	32	.	.	PUNCT
dti-1335	276	1	insulin	insulin	NOUN
dti-1335	276	2	-	-	PUNCT
dti-1335	276	3	like	like	ADJ
dti-1335	276	4	growth	growth	NOUN
dti-1335	276	5	factor	factor	NOUN
dti-1335	276	6	(	(	PUNCT
dti-1335	276	7	igf	igf	PROPN
dti-1335	276	8	)	)	PUNCT
dti-1335	276	9	signaling	signal	VERB
dti-1335	276	10	through	through	ADP
dti-1335	276	11	type	type	NOUN
dti-1335	276	12	1	1	NUM
dti-1335	276	13	igf	igf	PROPN
dti-1335	276	14	receptor	receptor	NOUN
dti-1335	276	15	plays	play	VERB
dti-1335	276	16	an	an	DET
dti-1335	276	17	important	important	ADJ
dti-1335	276	18	role	role	NOUN
dti-1335	276	19	in	in	ADP
dti-1335	276	20	remyelination	remyelination	NOUN
dti-1335	276	21	.	.	PUNCT
dti-1335	277	1	j.	j.	PROPN
dti-1335	277	2	neurosci	neurosci	PROPN
dti-1335	277	3	.	.	PROPN
dti-1335	277	4	,	,	PUNCT
dti-1335	277	5	23:7710–8	23:7710–8	NUM
dti-1335	277	6	.	.	PUNCT
dti-1335	278	1	mcmorris	mcmorris	PROPN
dti-1335	278	2	,	,	PUNCT
dti-1335	278	3	f.a	f.a	PROPN
dti-1335	278	4	.	.	PROPN
dti-1335	278	5	,	,	PUNCT
dti-1335	278	6	smith	smith	PROPN
dti-1335	278	7	,	,	PUNCT
dti-1335	278	8	t.m	t.m	PROPN
dti-1335	278	9	.	.	PROPN
dti-1335	278	10	,	,	PUNCT
dti-1335	278	11	desalvo	desalvo	PROPN
dti-1335	278	12	,	,	PUNCT
dti-1335	278	13	s.	s.	PROPN
dti-1335	278	14	et	et	PROPN
dti-1335	278	15	al	al	PROPN
dti-1335	278	16	.	.	PROPN
dti-1335	278	17	1986	1986	NUM
dti-1335	278	18	.	.	PUNCT
dti-1335	279	1	insulin	insulin	NOUN
dti-1335	279	2	-	-	PUNCT
dti-1335	279	3	like	like	ADJ
dti-1335	279	4	growth	growth	NOUN
dti-1335	279	5	factor	factor	NOUN
dti-1335	279	6	i	i	NOUN
dti-1335	279	7	/	/	SYM
dti-1335	279	8	somatomedin	somatomedin	VERB
dti-1335	279	9	c	c	NOUN
dti-1335	279	10	:	:	PUNCT
dti-1335	279	11	a	a	DET
dti-1335	279	12	potent	potent	ADJ
dti-1335	279	13	inducer	inducer	NOUN
dti-1335	279	14	of	of	ADP
dti-1335	279	15	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	279	16	development	development	NOUN
dti-1335	279	17	.	.	PUNCT
dti-1335	280	1	proc	proc	PROPN
dti-1335	280	2	.	.	PUNCT
dti-1335	281	1	natl	natl	PROPN
dti-1335	281	2	.	.	PUNCT
dti-1335	282	1	acad	acad	PROPN
dti-1335	282	2	.	.	PUNCT
dti-1335	283	1	sci	sci	PROPN
dti-1335	283	2	.	.	PROPN
dti-1335	283	3	,	,	PUNCT
dti-1335	283	4	u.s.a	u.s.a	PROPN
dti-1335	283	5	.	.	PROPN
dti-1335	283	6	,	,	PUNCT
dti-1335	283	7	83:822–6	83:822–6	NUM
dti-1335	283	8	.	.	PUNCT
dti-1335	284	1	morgan	morgan	PROPN
dti-1335	284	2	,	,	PUNCT
dti-1335	284	3	d.o	d.o	PROPN
dti-1335	284	4	.	.	PROPN
dti-1335	284	5	,	,	PUNCT
dti-1335	284	6	edman	edman	NOUN
dti-1335	284	7	,	,	PUNCT
dti-1335	284	8	j.c	j.c	PROPN
dti-1335	284	9	.	.	PROPN
dti-1335	284	10	,	,	PUNCT
dti-1335	284	11	standring	standring	NOUN
dti-1335	284	12	,	,	PUNCT
dti-1335	284	13	d.n	d.n	PROPN
dti-1335	284	14	.	.	PROPN
dti-1335	284	15	et	et	PROPN
dti-1335	284	16	al	al	PROPN
dti-1335	284	17	.	.	PROPN
dti-1335	284	18	1987	1987	NUM
dti-1335	284	19	.	.	PUNCT
dti-1335	285	1	insulin	insulin	NOUN
dti-1335	285	2	-	-	PUNCT
dti-1335	285	3	like	like	ADJ
dti-1335	285	4	growth	growth	NOUN
dti-1335	285	5	factor	factor	NOUN
dti-1335	285	6	ii	ii	NOUN
dti-1335	285	7	receptor	receptor	NOUN
dti-1335	285	8	as	as	ADP
dti-1335	285	9	a	a	DET
dti-1335	285	10	multifunctional	multifunctional	ADJ
dti-1335	285	11	binding	bind	VERB
dti-1335	285	12	protein	protein	NOUN
dti-1335	285	13	.	.	PUNCT
dti-1335	286	1	nature	nature	NOUN
dti-1335	286	2	,	,	PUNCT
dti-1335	286	3	329:301–7	329:301–7	PROPN
dti-1335	286	4	.	.	PUNCT
dti-1335	287	1	mozell	mozell	PROPN
dti-1335	287	2	,	,	PUNCT
dti-1335	287	3	r.l	r.l	PROPN
dti-1335	287	4	.	.	PROPN
dti-1335	287	5	and	and	CCONJ
dti-1335	287	6	mcmorris	mcmorris	PROPN
dti-1335	287	7	,	,	PUNCT
dti-1335	287	8	f.a	f.a	PROPN
dti-1335	287	9	.	.	PROPN
dti-1335	287	10	1991	1991	NUM
dti-1335	287	11	.	.	PUNCT
dti-1335	288	1	insulin	insulin	NOUN
dti-1335	288	2	-	-	PUNCT
dti-1335	288	3	like	like	ADJ
dti-1335	288	4	growth	growth	NOUN
dti-1335	288	5	factor	factor	NOUN
dti-1335	288	6	i	i	PRON
dti-1335	288	7	stimulates	stimulate	VERB
dti-1335	288	8	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	288	9	development	development	NOUN
dti-1335	288	10	and	and	CCONJ
dti-1335	288	11	myelination	myelination	NOUN
dti-1335	288	12	in	in	ADP
dti-1335	288	13	rat	rat	NOUN
dti-1335	288	14	brain	brain	NOUN
dti-1335	288	15	aggregate	aggregate	ADJ
dti-1335	288	16	cultures	culture	NOUN
dti-1335	288	17	.	.	PUNCT
dti-1335	289	1	j.	j.	PROPN
dti-1335	289	2	neurosci	neurosci	PROPN
dti-1335	289	3	.	.	PUNCT
dti-1335	290	1	res	re	NOUN
dti-1335	290	2	.	.	PROPN
dti-1335	290	3	,	,	PUNCT
dti-1335	290	4	30:382–90	30:382–90	NOUN
dti-1335	290	5	.	.	PUNCT
dti-1335	291	1	noseworthy	noseworthy	PROPN
dti-1335	291	2	,	,	PUNCT
dti-1335	291	3	j.h	j.h	PROPN
dti-1335	291	4	.	.	PROPN
dti-1335	291	5	,	,	PUNCT
dti-1335	291	6	luchinetti	luchinetti	PROPN
dti-1335	291	7	,	,	PUNCT
dti-1335	291	8	c.	c.	PROPN
dti-1335	291	9	,	,	PUNCT
dti-1335	291	10	rodriguez	rodriguez	PROPN
dti-1335	291	11	,	,	PUNCT
dti-1335	291	12	m.	m.	NOUN
dti-1335	291	13	et	et	PROPN
dti-1335	291	14	al	al	PROPN
dti-1335	291	15	.	.	PROPN
dti-1335	291	16	2000	2000	NUM
dti-1335	291	17	.	.	PUNCT
dti-1335	292	1	multiple	multiple	ADJ
dti-1335	292	2	sclerose	sclerose	NOUN
dti-1335	292	3	.	.	PUNCT
dti-1335	293	1	n.	n.	PROPN
dti-1335	293	2	engl	engl	PROPN
dti-1335	293	3	.	.	PUNCT
dti-1335	294	1	j.	j.	PROPN
dti-1335	294	2	med	med	PROPN
dti-1335	294	3	.	.	PROPN
dti-1335	294	4	,	,	PUNCT
dti-1335	295	1	343:938–52	343:938–52	NUM
dti-1335	295	2	.	.	PUNCT
dti-1335	296	1	ogata	ogata	PROPN
dti-1335	296	2	,	,	PUNCT
dti-1335	296	3	t.	t.	PROPN
dti-1335	296	4	,	,	PUNCT
dti-1335	296	5	iijima	iijima	PROPN
dti-1335	296	6	,	,	PUNCT
dti-1335	296	7	s.	s.	PROPN
dti-1335	296	8	,	,	PUNCT
dti-1335	296	9	hoshikawa	hoshikawa	PROPN
dti-1335	296	10	,	,	PUNCT
dti-1335	296	11	s.	s.	PROPN
dti-1335	296	12	et	et	PROPN
dti-1335	296	13	al	al	PROPN
dti-1335	296	14	.	.	PROPN
dti-1335	296	15	2004	2004	NUM
dti-1335	296	16	.	.	PUNCT
dti-1335	297	1	opposing	oppose	VERB
dti-1335	297	2	extracellular	extracellular	ADJ
dti-1335	297	3	signal	signal	NOUN
dti-1335	297	4	-	-	PUNCT
dti-1335	297	5	regulated	regulate	VERB
dti-1335	297	6	kinase	kinase	NOUN
dti-1335	297	7	and	and	CCONJ
dti-1335	297	8	akt	akt	PROPN
dti-1335	297	9	pathways	pathways	PROPN
dti-1335	297	10	controll	controll	PROPN
dti-1335	297	11	schwann	schwann	PROPN
dti-1335	297	12	cell	cell	NOUN
dti-1335	297	13	myelination	myelination	NOUN
dti-1335	297	14	.	.	PUNCT
dti-1335	298	1	j.	j.	PROPN
dti-1335	298	2	neurosci	neurosci	PROPN
dti-1335	298	3	.	.	PROPN
dti-1335	298	4	,	,	PUNCT
dti-1335	298	5	24:6724–32	24:6724–32	NUM
dti-1335	298	6	.	.	PUNCT
dti-1335	299	1	prineas	prineas	PROPN
dti-1335	299	2	,	,	PUNCT
dti-1335	299	3	j.w	j.w	PROPN
dti-1335	299	4	.	.	PROPN
dti-1335	299	5	,	,	PUNCT
dti-1335	299	6	barnard	barnard	PROPN
dti-1335	299	7	,	,	PUNCT
dti-1335	299	8	r.o	r.o	PROPN
dti-1335	299	9	.	.	PROPN
dti-1335	299	10	,	,	PUNCT
dti-1335	299	11	kwon	kwon	PROPN
dti-1335	299	12	,	,	PUNCT
dti-1335	299	13	e.e	e.e	PROPN
dti-1335	299	14	.	.	PROPN
dti-1335	299	15	et	et	PROPN
dti-1335	299	16	al	al	PROPN
dti-1335	299	17	.	.	PROPN
dti-1335	299	18	1993	1993	NUM
dti-1335	299	19	.	.	PUNCT
dti-1335	300	1	multiple	multiple	ADJ
dti-1335	300	2	sclerosis	sclerosis	NOUN
dti-1335	300	3	:	:	PUNCT
dti-1335	300	4	remyelination	remyelination	NOUN
dti-1335	300	5	of	of	ADP
dti-1335	300	6	nascent	nascent	ADJ
dti-1335	300	7	plaques	plaque	NOUN
dti-1335	300	8	.	.	PUNCT
dti-1335	301	1	ann	ann	PROPN
dti-1335	301	2	.	.	PUNCT
dti-1335	302	1	neurol	neurol	PROPN
dti-1335	302	2	.	.	PUNCT
dti-1335	302	3	,	,	PUNCT
dti-1335	302	4	33:137–51	33:137–51	X
dti-1335	302	5	.	.	PUNCT
dti-1335	303	1	rajaram	rajaram	PROPN
dti-1335	303	2	,	,	PUNCT
dti-1335	303	3	s.	s.	PROPN
dti-1335	303	4	,	,	PUNCT
dti-1335	303	5	baylink	baylink	PROPN
dti-1335	303	6	,	,	PUNCT
dti-1335	303	7	d.j	d.j	PROPN
dti-1335	303	8	.	.	PROPN
dti-1335	303	9	and	and	CCONJ
dti-1335	303	10	mohan	mohan	PROPN
dti-1335	303	11	,	,	PUNCT
dti-1335	303	12	s.	s.	PROPN
dti-1335	303	13	1997	1997	NUM
dti-1335	303	14	.	.	PUNCT
dti-1335	304	1	insulin	insulin	NOUN
dti-1335	304	2	-	-	PUNCT
dti-1335	304	3	like	like	ADJ
dti-1335	304	4	growth	growth	NOUN
dti-1335	304	5	factorbinding	factorbinde	VERB
dti-1335	304	6	proteins	protein	NOUN
dti-1335	304	7	in	in	ADP
dti-1335	304	8	serum	serum	NOUN
dti-1335	304	9	and	and	CCONJ
dti-1335	304	10	other	other	ADJ
dti-1335	304	11	biological	biological	ADJ
dti-1335	304	12	fl	fl	PROPN
dti-1335	304	13	uids	uids	PROPN
dti-1335	304	14	:	:	PUNCT
dti-1335	304	15	regulation	regulation	NOUN
dti-1335	304	16	and	and	CCONJ
dti-1335	304	17	function	function	NOUN
dti-1335	304	18	.	.	PUNCT
dti-1335	305	1	endocr	endocr	PROPN
dti-1335	305	2	.	.	PUNCT
dti-1335	306	1	rev	rev	PROPN
dti-1335	306	2	.	.	PROPN
dti-1335	306	3	,	,	PUNCT
dti-1335	306	4	18:801–31	18:801–31	NUM
dti-1335	306	5	.	.	PUNCT
dti-1335	307	1	reinhardt	reinhardt	PROPN
dti-1335	307	2	,	,	PUNCT
dti-1335	307	3	r.r	r.r	PROPN
dti-1335	307	4	.	.	PROPN
dti-1335	307	5	and	and	CCONJ
dti-1335	307	6	bondy	bondy	PROPN
dti-1335	307	7	,	,	PUNCT
dti-1335	307	8	c.a	c.a	PROPN
dti-1335	307	9	.	.	PROPN
dti-1335	307	10	1994	1994	NUM
dti-1335	307	11	.	.	PUNCT
dti-1335	308	1	insulin	insulin	NOUN
dti-1335	308	2	-	-	PUNCT
dti-1335	308	3	like	like	ADJ
dti-1335	308	4	growth	growth	NOUN
dti-1335	308	5	factors	factor	NOUN
dti-1335	308	6	cross	cross	VERB
dti-1335	308	7	the	the	DET
dti-1335	308	8	blood	blood	NOUN
dti-1335	308	9	-	-	PUNCT
dti-1335	308	10	brain	brain	NOUN
dti-1335	308	11	barrier	barrier	NOUN
dti-1335	308	12	.	.	PUNCT
dti-1335	309	1	endocrinology	endocrinology	NOUN
dti-1335	309	2	,	,	PUNCT
dti-1335	309	3	135:1753–61	135:1753–61	NUM
dti-1335	309	4	.	.	PUNCT
dti-1335	310	1	roth	roth	PROPN
dti-1335	310	2	,	,	PUNCT
dti-1335	310	3	g.a	g.a	PROPN
dti-1335	310	4	.	.	PROPN
dti-1335	310	5	,	,	PUNCT
dti-1335	310	6	spada	spada	PROPN
dti-1335	310	7	,	,	PUNCT
dti-1335	310	8	v.	v.	PROPN
dti-1335	310	9	,	,	PUNCT
dti-1335	310	10	hamill	hamill	PROPN
dti-1335	310	11	,	,	PUNCT
dti-1335	310	12	k.	k.	PROPN
dti-1335	310	13	et	et	PROPN
dti-1335	310	14	al	al	PROPN
dti-1335	310	15	.	.	PROPN
dti-1335	310	16	1995	1995	NUM
dti-1335	310	17	.	.	PUNCT
dti-1335	311	1	insulin	insulin	NOUN
dti-1335	311	2	-	-	PUNCT
dti-1335	311	3	like	like	ADJ
dti-1335	311	4	growth	growth	NOUN
dti-1335	311	5	factor	factor	NOUN
dti-1335	311	6	i	i	PRON
dti-1335	311	7	increases	increase	VERB
dti-1335	311	8	myelination	myelination	NOUN
dti-1335	311	9	and	and	CCONJ
dti-1335	311	10	inhibit	inhibit	VERB
dti-1335	311	11	demyelination	demyelination	NOUN
dti-1335	311	12	in	in	ADP
dti-1335	311	13	cultured	cultured	ADJ
dti-1335	311	14	organotypic	organotypic	ADJ
dti-1335	311	15	nerve	nerve	NOUN
dti-1335	311	16	tissue	tissue	NOUN
dti-1335	311	17	.	.	PUNCT
dti-1335	312	1	brain	brain	NOUN
dti-1335	312	2	res	re	NOUN
dti-1335	312	3	.	.	PUNCT
dti-1335	313	1	dev	dev	PROPN
dti-1335	313	2	.	.	PUNCT
dti-1335	313	3	brain	brain	NOUN
dti-1335	313	4	res	re	NOUN
dti-1335	313	5	.	.	PROPN
dti-1335	313	6	,	,	PUNCT
dti-1335	313	7	88:102–8	88:102–8	NUM
dti-1335	313	8	.	.	PUNCT
dti-1335	314	1	russo	russo	PROPN
dti-1335	314	2	,	,	PUNCT
dti-1335	314	3	v.c	v.c	PROPN
dti-1335	314	4	.	.	PROPN
dti-1335	314	5	,	,	PUNCT
dti-1335	314	6	bach	bach	PROPN
dti-1335	314	7	,	,	PUNCT
dti-1335	314	8	l.a	l.a	PROPN
dti-1335	314	9	.	.	PROPN
dti-1335	314	10	,	,	PUNCT
dti-1335	314	11	fosang	fosang	PROPN
dti-1335	314	12	,	,	PUNCT
dti-1335	314	13	a.j	a.j	PROPN
dti-1335	314	14	.	.	PROPN
dti-1335	314	15	et	et	PROPN
dti-1335	314	16	al	al	PROPN
dti-1335	314	17	.	.	PROPN
dti-1335	314	18	1997	1997	NUM
dti-1335	314	19	.	.	PUNCT
dti-1335	315	1	insulin	insulin	NOUN
dti-1335	315	2	-	-	PUNCT
dti-1335	315	3	like	like	ADJ
dti-1335	315	4	growth	growth	NOUN
dti-1335	315	5	factor	factor	NOUN
dti-1335	315	6	binding	bind	VERB
dti-1335	315	7	protein-2	protein-2	NOUN
dti-1335	315	8	binds	bind	VERB
dti-1335	315	9	to	to	ADP
dti-1335	315	10	cell	cell	NOUN
dti-1335	315	11	surface	surface	NOUN
dti-1335	315	12	proteoglycans	proteoglycan	NOUN
dti-1335	315	13	in	in	ADP
dti-1335	315	14	the	the	DET
dti-1335	315	15	rat	rat	NOUN
dti-1335	315	16	brain	brain	NOUN
dti-1335	315	17	olfactory	olfactory	NOUN
dti-1335	315	18	bulb	bulb	PROPN
dti-1335	315	19	.	.	PUNCT
dti-1335	316	1	endocrinology	endocrinology	NOUN
dti-1335	316	2	,	,	PUNCT
dti-1335	316	3	138:4858–67	138:4858–67	NUM
dti-1335	316	4	.	.	PUNCT
dti-1335	317	1	russo	russo	PROPN
dti-1335	317	2	,	,	PUNCT
dti-1335	317	3	v.c	v.c	PROPN
dti-1335	317	4	.	.	PROPN
dti-1335	317	5	,	,	PUNCT
dti-1335	317	6	gluckman	gluckman	PROPN
dti-1335	317	7	,	,	PUNCT
dti-1335	317	8	p.d	p.d	PROPN
dti-1335	317	9	.	.	PROPN
dti-1335	317	10	,	,	PUNCT
dti-1335	317	11	feldman	feldman	PROPN
dti-1335	317	12	,	,	PUNCT
dti-1335	317	13	e.l	e.l	PROPN
dti-1335	317	14	.	.	PROPN
dti-1335	317	15	et	et	PROPN
dti-1335	317	16	al	al	PROPN
dti-1335	317	17	.	.	PROPN
dti-1335	317	18	2005	2005	NUM
dti-1335	317	19	.	.	PUNCT
dti-1335	318	1	the	the	DET
dti-1335	318	2	insulin	insulin	NOUN
dti-1335	318	3	-	-	PUNCT
dti-1335	318	4	like	like	ADJ
dti-1335	318	5	growth	growth	NOUN
dti-1335	318	6	factor	factor	NOUN
dti-1335	318	7	system	system	NOUN
dti-1335	318	8	and	and	CCONJ
dti-1335	318	9	its	its	PRON
dti-1335	318	10	pleiotrophic	pleiotrophic	ADJ
dti-1335	318	11	functions	function	NOUN
dti-1335	318	12	in	in	ADP
dti-1335	318	13	brain	brain	NOUN
dti-1335	318	14	.	.	PUNCT
dti-1335	319	1	endocr	endocr	PROPN
dti-1335	319	2	.	.	PUNCT
dti-1335	320	1	rev	rev	PROPN
dti-1335	320	2	.	.	PROPN
dti-1335	320	3	,	,	PUNCT
dti-1335	320	4	26:916–43	26:916–43	PROPN
dti-1335	320	5	.	.	PUNCT
dti-1335	321	1	sara	sara	PROPN
dti-1335	321	2	,	,	PUNCT
dti-1335	321	3	v.r	v.r	PROPN
dti-1335	321	4	.	.	PROPN
dti-1335	321	5	,	,	PUNCT
dti-1335	321	6	carlsson	carlsson	PROPN
dti-1335	321	7	-	-	PUNCT
dti-1335	321	8	skwirut	skwirut	PROPN
dti-1335	321	9	,	,	PUNCT
dti-1335	321	10	c.	c.	PROPN
dti-1335	321	11	,	,	PUNCT
dti-1335	321	12	anderson	anderson	PROPN
dti-1335	321	13	,	,	PUNCT
dti-1335	321	14	c.	c.	PROPN
dti-1335	321	15	et	et	PROPN
dti-1335	321	16	al	al	PROPN
dti-1335	321	17	.	.	PROPN
dti-1335	321	18	1986	1986	NUM
dti-1335	321	19	.	.	PUNCT
dti-1335	322	1	characterization	characterization	NOUN
dti-1335	322	2	of	of	ADP
dti-1335	322	3	somatomedins	somatomedin	NOUN
dti-1335	322	4	from	from	ADP
dti-1335	322	5	human	human	ADJ
dti-1335	322	6	fetal	fetal	ADJ
dti-1335	322	7	brain	brain	NOUN
dti-1335	322	8	:	:	PUNCT
dti-1335	322	9	identifi	identifi	PROPN
dti-1335	322	10	cation	cation	NOUN
dti-1335	322	11	of	of	ADP
dti-1335	322	12	a	a	DET
dti-1335	322	13	variant	variant	ADJ
dti-1335	322	14	form	form	NOUN
dti-1335	322	15	of	of	ADP
dti-1335	322	16	insulin	insulin	NOUN
dti-1335	322	17	-	-	PUNCT
dti-1335	322	18	like	like	ADJ
dti-1335	322	19	growth	growth	NOUN
dti-1335	322	20	factor	factor	NOUN
dti-1335	322	21	-	-	PUNCT
dti-1335	322	22	i.	i.	NOUN
dti-1335	322	23	proc	proc	PROPN
dti-1335	322	24	.	.	PUNCT
dti-1335	323	1	natl	natl	PROPN
dti-1335	323	2	.	.	PUNCT
dti-1335	324	1	acad	acad	PROPN
dti-1335	324	2	.	.	PUNCT
dti-1335	325	1	sci	sci	PROPN
dti-1335	325	2	.	.	PROPN
dti-1335	325	3	,	,	PUNCT
dti-1335	325	4	u.s.a	u.s.a	PROPN
dti-1335	325	5	.	.	PROPN
dti-1335	325	6	,	,	PUNCT
dti-1335	325	7	83:4904–7	83:4904–7	NUM
dti-1335	325	8	.	.	PUNCT
dti-1335	326	1	scolding	scold	VERB
dti-1335	326	2	,	,	PUNCT
dti-1335	326	3	n.	n.	PROPN
dti-1335	326	4	,	,	PUNCT
dti-1335	326	5	franklin	franklin	PROPN
dti-1335	326	6	,	,	PUNCT
dti-1335	326	7	r.	r.	PROPN
dti-1335	326	8	,	,	PUNCT
dti-1335	326	9	stevens	stevens	PROPN
dti-1335	326	10	,	,	PUNCT
dti-1335	326	11	s.	s.	PROPN
dti-1335	326	12	et	et	PROPN
dti-1335	326	13	al	al	PROPN
dti-1335	326	14	.	.	PROPN
dti-1335	326	15	1998	1998	NUM
dti-1335	326	16	.	.	PUNCT
dti-1335	327	1	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	327	2	progenitors	progenitor	NOUN
dti-1335	327	3	are	be	AUX
dti-1335	327	4	present	present	ADJ
dti-1335	327	5	in	in	ADP
dti-1335	327	6	the	the	DET
dti-1335	327	7	normal	normal	ADJ
dti-1335	327	8	adult	adult	NOUN
dti-1335	327	9	human	human	ADJ
dti-1335	327	10	cns	cns	NOUN
dti-1335	327	11	and	and	CCONJ
dti-1335	327	12	in	in	ADP
dti-1335	327	13	the	the	DET
dti-1335	327	14	lesions	lesion	NOUN
dti-1335	327	15	of	of	ADP
dti-1335	327	16	multiple	multiple	ADJ
dti-1335	327	17	sclerosis	sclerosis	NOUN
dti-1335	327	18	.	.	PUNCT
dti-1335	328	1	brain	brain	NOUN
dti-1335	328	2	,	,	PUNCT
dti-1335	328	3	121:2221–8	121:2221–8	NUM
dti-1335	328	4	.	.	PUNCT
dti-1335	329	1	spagnoli	spagnoli	PROPN
dti-1335	329	2	,	,	PUNCT
dti-1335	329	3	a.	a.	NOUN
dti-1335	329	4	and	and	CCONJ
dti-1335	329	5	rosenfeld	rosenfeld	PROPN
dti-1335	329	6	,	,	PUNCT
dti-1335	329	7	r.g	r.g	PROPN
dti-1335	329	8	.	.	PROPN
dti-1335	329	9	1997	1997	NUM
dti-1335	329	10	.	.	PUNCT
dti-1335	330	1	insulin	insulin	NOUN
dti-1335	330	2	-	-	PUNCT
dti-1335	330	3	like	like	ADJ
dti-1335	330	4	growth	growth	NOUN
dti-1335	330	5	factor	factor	NOUN
dti-1335	330	6	binding	bind	VERB
dti-1335	330	7	proteins	protein	NOUN
dti-1335	330	8	.	.	PUNCT
dti-1335	331	1	curr	curr	PROPN
dti-1335	331	2	.	.	PUNCT
dti-1335	331	3	opinion	opinion	NOUN
dti-1335	331	4	endocrinol	endocrinol	NOUN
dti-1335	331	5	.	.	PUNCT
dti-1335	331	6	,	,	PUNCT
dti-1335	331	7	4:1–9	4:1–9	PROPN
dti-1335	331	8	.	.	PUNCT
dti-1335	331	9	steinman	steinman	PROPN
dti-1335	331	10	,	,	PUNCT
dti-1335	331	11	l.	l.	PROPN
dti-1335	331	12	1996	1996	NUM
dti-1335	331	13	.	.	PUNCT
dti-1335	332	1	multiple	multiple	ADJ
dti-1335	332	2	sclerosis	sclerosis	NOUN
dti-1335	332	3	:	:	PUNCT
dti-1335	332	4	a	a	DET
dti-1335	332	5	coordinated	coordinate	VERB
dti-1335	332	6	immunological	immunological	ADJ
dti-1335	332	7	attack	attack	NOUN
dti-1335	332	8	against	against	ADP
dti-1335	332	9	myelin	myelin	NOUN
dti-1335	332	10	in	in	ADP
dti-1335	332	11	the	the	DET
dti-1335	332	12	central	central	ADJ
dti-1335	332	13	nervous	nervous	ADJ
dti-1335	332	14	system	system	NOUN
dti-1335	332	15	.	.	PUNCT
dti-1335	333	1	cell	cell	NOUN
dti-1335	333	2	,	,	PUNCT
dti-1335	333	3	85:299–302	85:299–302	NUM
dti-1335	333	4	.	.	PUNCT
dti-1335	334	1	syroid	syroid	NOUN
dti-1335	334	2	,	,	PUNCT
dti-1335	334	3	d.e	d.e	PROPN
dti-1335	334	4	.	.	PROPN
dti-1335	334	5	,	,	PUNCT
dti-1335	334	6	zorick	zorick	PROPN
dti-1335	334	7	,	,	PUNCT
dti-1335	334	8	t.s	t.s	PROPN
dti-1335	334	9	.	.	PROPN
dti-1335	334	10	,	,	PUNCT
dti-1335	334	11	arbet	arbet	PROPN
dti-1335	334	12	-	-	PUNCT
dti-1335	334	13	engels	engel	NOUN
dti-1335	334	14	,	,	PUNCT
dti-1335	334	15	c.	c.	PROPN
dti-1335	334	16	et	et	PROPN
dti-1335	334	17	al	al	PROPN
dti-1335	334	18	.	.	PROPN
dti-1335	334	19	1999	1999	NUM
dti-1335	334	20	.	.	PUNCT
dti-1335	335	1	a	a	DET
dti-1335	335	2	role	role	NOUN
dti-1335	335	3	for	for	ADP
dti-1335	335	4	insulinlike	insulinlike	ADJ
dti-1335	335	5	growth	growth	NOUN
dti-1335	335	6	factor	factor	NOUN
dti-1335	335	7	-	-	PUNCT
dti-1335	335	8	i	i	PRON
dti-1335	335	9	in	in	ADP
dti-1335	335	10	the	the	DET
dti-1335	335	11	regulation	regulation	NOUN
dti-1335	335	12	of	of	ADP
dti-1335	335	13	schwann	schwann	PROPN
dti-1335	335	14	cell	cell	NOUN
dti-1335	335	15	survival	survival	NOUN
dti-1335	335	16	.	.	PUNCT
dti-1335	336	1	ageing	age	VERB
dti-1335	336	2	res	re	NOUN
dti-1335	336	3	.	.	PUNCT
dti-1335	337	1	rev	rev	PROPN
dti-1335	337	2	.	.	PROPN
dti-1335	337	3	,	,	PUNCT
dti-1335	337	4	4:195–212	4:195–212	NUM
dti-1335	337	5	.	.	PUNCT
dti-1335	337	6	tanno	tanno	PROPN
dti-1335	337	7	,	,	PUNCT
dti-1335	337	8	b.	b.	PROPN
dti-1335	337	9	,	,	PUNCT
dti-1335	337	10	cesi	cesi	PROPN
dti-1335	337	11	,	,	PUNCT
dti-1335	337	12	v.	v.	PROPN
dti-1335	337	13	,	,	PUNCT
dti-1335	337	14	vitali	vitali	PROPN
dti-1335	337	15	,	,	PUNCT
dti-1335	337	16	r.	r.	PROPN
dti-1335	337	17	et	et	PROPN
dti-1335	337	18	al	al	PROPN
dti-1335	337	19	.	.	PROPN
dti-1335	337	20	2005	2005	NUM
dti-1335	337	21	.	.	PUNCT
dti-1335	338	1	silencing	silence	VERB
dti-1335	338	2	of	of	ADP
dti-1335	338	3	endogenous	endogenous	ADJ
dti-1335	338	4	igfbp-5	igfbp-5	NUM
dti-1335	338	5	by	by	ADP
dti-1335	338	6	micro	micro	ADJ
dti-1335	338	7	rna	rna	PROPN
dti-1335	338	8	interference	interference	NOUN
dti-1335	338	9	affects	affect	VERB
dti-1335	338	10	proliferation	proliferation	NOUN
dti-1335	338	11	,	,	PUNCT
dti-1335	338	12	apoptosis	apoptosis	NOUN
dti-1335	338	13	and	and	CCONJ
dti-1335	338	14	differentiation	differentiation	NOUN
dti-1335	338	15	of	of	ADP
dti-1335	338	16	neuroblastoma	neuroblastoma	ADJ
dti-1335	338	17	cells	cell	NOUN
dti-1335	338	18	.	.	PUNCT
dti-1335	339	1	cell	cell	NOUN
dti-1335	339	2	.	.	PUNCT
dti-1335	340	1	death	death	NOUN
dti-1335	340	2	diff	diff	PROPN
dti-1335	340	3	.	.	PUNCT
dti-1335	340	4	,	,	PUNCT
dti-1335	340	5	12:213–23	12:213–23	PROPN
dti-1335	340	6	.	.	PUNCT
dti-1335	341	1	thorne	thorne	PROPN
dti-1335	341	2	,	,	PUNCT
dti-1335	341	3	r.g	r.g	PROPN
dti-1335	341	4	.	.	PROPN
dti-1335	341	5	,	,	PUNCT
dti-1335	341	6	pronk	pronk	PROPN
dti-1335	341	7	,	,	PUNCT
dti-1335	341	8	g.j	g.j	PROPN
dti-1335	341	9	.	.	PROPN
dti-1335	341	10	,	,	PUNCT
dti-1335	341	11	padmanabhan	padmanabhan	PROPN
dti-1335	341	12	,	,	PUNCT
dti-1335	341	13	v.	v.	ADP
dti-1335	341	14	et	et	PROPN
dti-1335	341	15	al	al	PROPN
dti-1335	341	16	.	.	PROPN
dti-1335	341	17	2004	2004	NUM
dti-1335	341	18	.	.	PUNCT
dti-1335	342	1	delivery	delivery	NOUN
dti-1335	342	2	of	of	ADP
dti-1335	342	3	insulinlike	insulinlike	ADJ
dti-1335	342	4	growth	growth	NOUN
dti-1335	342	5	factor	factor	NOUN
dti-1335	342	6	-	-	PUNCT
dti-1335	342	7	i	i	NOUN
dti-1335	342	8	to	to	ADP
dti-1335	342	9	the	the	DET
dti-1335	342	10	rat	rat	NOUN
dti-1335	342	11	brain	brain	NOUN
dti-1335	342	12	and	and	CCONJ
dti-1335	342	13	spinal	spinal	ADJ
dti-1335	342	14	cord	cord	NOUN
dti-1335	342	15	along	along	ADP
dti-1335	342	16	olfactory	olfactory	NOUN
dti-1335	342	17	and	and	CCONJ
dti-1335	342	18	trigeminal	trigeminal	ADJ
dti-1335	342	19	pathways	pathway	NOUN
dti-1335	342	20	following	follow	VERB
dti-1335	342	21	intranasal	intranasal	ADJ
dti-1335	342	22	administration	administration	NOUN
dti-1335	342	23	.	.	PUNCT
dti-1335	343	1	neuroscience	neuroscience	NOUN
dti-1335	343	2	,	,	PUNCT
dti-1335	343	3	127:481–96	127:481–96	NUM
dti-1335	343	4	.	.	PUNCT
dti-1335	344	1	tranque	tranque	PROPN
dti-1335	344	2	,	,	PUNCT
dti-1335	344	3	p.a	p.a	PROPN
dti-1335	344	4	.	.	PROPN
dti-1335	344	5	,	,	PUNCT
dti-1335	344	6	calle	calle	PROPN
dti-1335	344	7	,	,	PUNCT
dti-1335	344	8	r.	r.	PROPN
dti-1335	344	9	,	,	PUNCT
dti-1335	344	10	naftolin	naftolin	PROPN
dti-1335	344	11	,	,	PUNCT
dti-1335	344	12	f.	f.	PROPN
dti-1335	344	13	et	et	PROPN
dti-1335	344	14	al	al	PROPN
dti-1335	344	15	.	.	PROPN
dti-1335	344	16	1992	1992	NUM
dti-1335	344	17	.	.	PUNCT
dti-1335	345	1	involvement	involvement	NOUN
dti-1335	345	2	of	of	ADP
dti-1335	345	3	protein	protein	NOUN
dti-1335	345	4	kinase	kinase	PROPN
dti-1335	345	5	-	-	PUNCT
dti-1335	345	6	c	c	PROPN
dti-1335	345	7	in	in	ADP
dti-1335	345	8	the	the	DET
dti-1335	345	9	mitogenic	mitogenic	ADJ
dti-1335	345	10	effects	effect	NOUN
dti-1335	345	11	of	of	ADP
dti-1335	345	12	insulin	insulin	NOUN
dti-1335	345	13	-	-	PUNCT
dti-1335	345	14	like	like	ADJ
dti-1335	345	15	growth	growth	NOUN
dti-1335	345	16	factor	factor	NOUN
dti-1335	345	17	i	i	PRON
dti-1335	345	18	on	on	ADP
dti-1335	345	19	rat	rat	NOUN
dti-1335	345	20	astrocytes	astrocyte	NOUN
dti-1335	345	21	.	.	PUNCT
dti-1335	346	1	endocrinology	endocrinology	NOUN
dti-1335	346	2	,	,	PUNCT
dti-1335	346	3	131:1948–54	131:1948–54	NUM
dti-1335	346	4	.	.	PUNCT
dti-1335	347	1	weihong	weihong	NOUN
dti-1335	347	2	,	,	PUNCT
dti-1335	347	3	p.	p.	NOUN
dti-1335	347	4	and	and	CCONJ
dti-1335	347	5	kastin	kastin	PROPN
dti-1335	347	6	,	,	PUNCT
dti-1335	347	7	a.j	a.j	PROPN
dti-1335	347	8	.	.	PROPN
dti-1335	347	9	2000	2000	NUM
dti-1335	347	10	.	.	PUNCT
dti-1335	348	1	interactions	interaction	NOUN
dti-1335	348	2	of	of	ADP
dti-1335	348	3	igf-1	igf-1	NOUN
dti-1335	348	4	with	with	ADP
dti-1335	348	5	the	the	DET
dti-1335	348	6	bloodbrain	bloodbrain	NOUN
dti-1335	348	7	barrier	barrier	NOUN
dti-1335	348	8	in	in	ADP
dti-1335	348	9	vivo	vivo	NOUN
dti-1335	348	10	and	and	CCONJ
dti-1335	348	11	in	in	ADP
dti-1335	348	12	situ	situ	NOUN
dti-1335	348	13	.	.	PUNCT
dti-1335	349	1	neuroendocrinology	neuroendocrinology	NOUN
dti-1335	349	2	,	,	PUNCT
dti-1335	349	3	72:171–8	72:171–8	NUM
dti-1335	349	4	.	.	PUNCT
dti-1335	350	1	wilczak	wilczak	PROPN
dti-1335	350	2	,	,	PUNCT
dti-1335	350	3	n.	n.	NOUN
dti-1335	350	4	and	and	CCONJ
dti-1335	350	5	de	de	PROPN
dti-1335	350	6	keyser	keyser	PROPN
dti-1335	350	7	,	,	PUNCT
dti-1335	350	8	j.	j.	PROPN
dti-1335	350	9	1997	1997	NUM
dti-1335	350	10	.	.	PUNCT
dti-1335	351	1	insulin	insulin	NOUN
dti-1335	351	2	-	-	PUNCT
dti-1335	351	3	like	like	ADJ
dti-1335	351	4	growth	growth	NOUN
dti-1335	351	5	factor	factor	NOUN
dti-1335	351	6	-	-	PUNCT
dti-1335	351	7	i	i	PRON
dti-1335	351	8	receptors	receptor	NOUN
dti-1335	351	9	in	in	ADP
dti-1335	351	10	normal	normal	ADJ
dti-1335	351	11	appearing	appear	VERB
dti-1335	351	12	white	white	ADJ
dti-1335	351	13	matter	matter	NOUN
dti-1335	351	14	and	and	CCONJ
dti-1335	351	15	chronic	chronic	ADJ
dti-1335	351	16	plaques	plaque	NOUN
dti-1335	351	17	in	in	ADP
dti-1335	351	18	multiple	multiple	ADJ
dti-1335	351	19	sclerosis	sclerosis	NOUN
dti-1335	351	20	.	.	PUNCT
dti-1335	352	1	brain	brain	NOUN
dti-1335	352	2	res	re	NOUN
dti-1335	352	3	.	.	PUNCT
dti-1335	352	4	,	,	PUNCT
dti-1335	353	1	772:243–6	772:243–6	PROPN
dti-1335	353	2	.	.	PUNCT
dti-1335	354	1	wolswijk	wolswijk	PROPN
dti-1335	354	2	,	,	PUNCT
dti-1335	354	3	g.	g.	PROPN
dti-1335	354	4	2000	2000	NUM
dti-1335	354	5	.	.	PUNCT
dti-1335	355	1	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	355	2	survival	survival	NOUN
dti-1335	355	3	,	,	PUNCT
dti-1335	355	4	loss	loss	NOUN
dti-1335	355	5	and	and	CCONJ
dti-1335	355	6	birth	birth	NOUN
dti-1335	355	7	in	in	ADP
dti-1335	355	8	plaques	plaque	NOUN
dti-1335	355	9	of	of	ADP
dti-1335	355	10	chronic	chronic	ADJ
dti-1335	355	11	-	-	PUNCT
dti-1335	355	12	stage	stage	NOUN
dti-1335	355	13	multiple	multiple	ADJ
dti-1335	355	14	sclerosis	sclerosis	NOUN
dti-1335	355	15	.	.	PUNCT
dti-1335	356	1	brain	brain	NOUN
dti-1335	356	2	,	,	PUNCT
dti-1335	356	3	123:105–15	123:105–15	PROPN
dti-1335	356	4	.	.	PUNCT
dti-1335	356	5	wolswijk	wolswijk	PROPN
dti-1335	356	6	,	,	PUNCT
dti-1335	356	7	g.	g.	PROPN
dti-1335	356	8	2002	2002	NUM
dti-1335	356	9	.	.	PUNCT
dti-1335	357	1	oligodendrocyte	oligodendrocyte	ADJ
dti-1335	357	2	precursor	precursor	NOUN
dti-1335	357	3	cells	cell	NOUN
dti-1335	357	4	in	in	ADP
dti-1335	357	5	demyelinated	demyelinate	VERB
dti-1335	357	6	multiple	multiple	ADJ
dti-1335	357	7	sclerosis	sclerosis	NOUN
dti-1335	357	8	spinal	spinal	NOUN
dti-1335	357	9	cord	cord	NOUN
dti-1335	357	10	.	.	PUNCT
dti-1335	358	1	brain	brain	NOUN
dti-1335	358	2	,	,	PUNCT
dti-1335	358	3	125:338–49	125:338–49	PROPN
dti-1335	358	4	.	.	PUNCT
dti-1335	359	1	yamasaki	yamasaki	PROPN
dti-1335	359	2	,	,	PUNCT
dti-1335	359	3	h.	h.	PROPN
dti-1335	359	4	,	,	PUNCT
dti-1335	359	5	prager	prager	PROPN
dti-1335	359	6	,	,	PUNCT
dti-1335	359	7	d.	d.	PROPN
dti-1335	359	8	and	and	CCONJ
dti-1335	359	9	melmed	melme	VERB
dti-1335	359	10	,	,	PUNCT
dti-1335	359	11	s.	s.	PROPN
dti-1335	359	12	1993	1993	NUM
dti-1335	359	13	.	.	PUNCT
dti-1335	360	1	structure	structure	NOUN
dti-1335	360	2	-	-	PUNCT
dti-1335	360	3	function	function	NOUN
dti-1335	360	4	of	of	ADP
dti-1335	360	5	the	the	DET
dti-1335	360	6	human	human	ADJ
dti-1335	360	7	insulin	insulin	NOUN
dti-1335	360	8	-	-	PUNCT
dti-1335	360	9	like	like	ADJ
dti-1335	360	10	growth	growth	NOUN
dti-1335	360	11	factor	factor	NOUN
dti-1335	360	12	receptor	receptor	NOUN
dti-1335	360	13	-	-	PUNCT
dti-1335	360	14	i	i	PRON
dti-1335	360	15	:	:	PUNCT
dti-1335	360	16	a	a	DET
dti-1335	360	17	discordance	discordance	NOUN
dti-1335	360	18	of	of	ADP
dti-1335	360	19	somatotroph	somatotroph	PROPN
dti-1335	360	20	internalization	internalization	NOUN
dti-1335	360	21	and	and	CCONJ
dti-1335	360	22	signaling	signaling	ADJ
dti-1335	360	23	.	.	PUNCT
dti-1335	361	1	mol	mol	PROPN
dti-1335	361	2	.	.	PROPN
dti-1335	361	3	endocrinol	endocrinol	NOUN
dti-1335	361	4	.	.	PUNCT
dti-1335	361	5	,	,	PUNCT
dti-1335	362	1	7:681–5	7:681–5	X
dti-1335	362	2	.	.	PUNCT
dti-1335	362	3	yao	yao	PROPN
dti-1335	362	4	,	,	PUNCT
dti-1335	362	5	d.l	d.l	PROPN
dti-1335	362	6	.	.	PROPN
dti-1335	362	7	,	,	PUNCT
dti-1335	362	8	liu	liu	PROPN
dti-1335	362	9	,	,	PUNCT
dti-1335	362	10	x.	x.	PROPN
dti-1335	362	11	,	,	PUNCT
dti-1335	362	12	hudson	hudson	PROPN
dti-1335	362	13	,	,	PUNCT
dti-1335	362	14	l.d	l.d	PROPN
dti-1335	362	15	.	.	PROPN
dti-1335	362	16	et	et	PROPN
dti-1335	362	17	al	al	PROPN
dti-1335	362	18	.	.	PROPN
dti-1335	362	19	1995	1995	NUM
dti-1335	362	20	.	.	PUNCT
dti-1335	363	1	insulin	insulin	NOUN
dti-1335	363	2	-	-	PUNCT
dti-1335	363	3	like	like	ADJ
dti-1335	363	4	growth	growth	NOUN
dti-1335	363	5	factor	factor	NOUN
dti-1335	363	6	i	i	PRON
dti-1335	363	7	treatment	treatment	NOUN
dti-1335	363	8	reduces	reduce	VERB
dti-1335	363	9	demyelination	demyelination	NOUN
dti-1335	363	10	and	and	CCONJ
dti-1335	363	11	up	up	NOUN
dti-1335	363	12	-	-	PUNCT
dti-1335	363	13	regulates	regulate	VERB
dti-1335	363	14	gene	gene	NOUN
dti-1335	363	15	expression	expression	NOUN
dti-1335	363	16	of	of	ADP
dti-1335	363	17	myelin	myelin	NOUN
dti-1335	363	18	-	-	PUNCT
dti-1335	363	19	related	relate	VERB
dti-1335	363	20	prpteins	prptein	NOUN
dti-1335	363	21	in	in	ADP
dti-1335	363	22	experimental	experimental	ADJ
dti-1335	363	23	autoimmune	autoimmune	ADJ
dti-1335	363	24	encephalomyelitis	encephalomyelitis	NOUN
dti-1335	363	25	.	.	PUNCT
dti-1335	364	1	proc	proc	PROPN
dti-1335	364	2	.	.	PUNCT
dti-1335	365	1	natl	natl	PROPN
dti-1335	365	2	.	.	PUNCT
dti-1335	366	1	acad	acad	PROPN
dti-1335	366	2	.	.	PUNCT
dti-1335	367	1	sci	sci	PROPN
dti-1335	367	2	.	.	PROPN
dti-1335	367	3	,	,	PUNCT
dti-1335	367	4	u.s.a	u.s.a	PROPN
dti-1335	367	5	.	.	PROPN
dti-1335	367	6	,	,	PUNCT
dti-1335	367	7	92:6190–4	92:6190–4	NUM
dti-1335	367	8	.	.	PUNCT
dti-1335	368	1	ye	ye	NUM
dti-1335	368	2	,	,	PUNCT
dti-1335	368	3	p.	p.	NOUN
dti-1335	368	4	,	,	PUNCT
dti-1335	368	5	carson	carson	PROPN
dti-1335	368	6	,	,	PUNCT
dti-1335	368	7	j.	j.	PROPN
dti-1335	368	8	and	and	CCONJ
dti-1335	368	9	d	d	NOUN
dti-1335	368	10	'	'	PUNCT
dti-1335	368	11	ercole	ercole	NOUN
dti-1335	368	12	,	,	PUNCT
dti-1335	368	13	a.j	a.j	PROPN
dti-1335	368	14	.	.	PROPN
dti-1335	368	15	1995	1995	NUM
dti-1335	368	16	.	.	PUNCT
dti-1335	369	1	in	in	ADP
dti-1335	369	2	vivo	vivo	ADJ
dti-1335	369	3	actions	action	NOUN
dti-1335	369	4	of	of	ADP
dti-1335	369	5	insulin	insulin	NOUN
dti-1335	369	6	-	-	PUNCT
dti-1335	369	7	like	like	ADJ
dti-1335	369	8	growth	growth	NOUN
dti-1335	369	9	factor	factor	NOUN
dti-1335	369	10	-	-	PUNCT
dti-1335	369	11	i	i	PRON
dti-1335	369	12	(	(	PUNCT
dti-1335	369	13	igf	igf	PROPN
dti-1335	369	14	-	-	PROPN
dti-1335	369	15	i	i	PROPN
dti-1335	369	16	)	)	PUNCT
dti-1335	369	17	on	on	ADP
dti-1335	369	18	brain	brain	NOUN
dti-1335	369	19	myeliation	myeliation	NOUN
dti-1335	369	20	:	:	PUNCT
dti-1335	369	21	studies	study	NOUN
dti-1335	369	22	of	of	ADP
dti-1335	369	23	igf	igf	PROPN
dti-1335	369	24	-	-	PROPN
dti-1335	369	25	i	i	PROPN
dti-1335	369	26	and	and	CCONJ
dti-1335	369	27	igf	igf	PROPN
dti-1335	369	28	binding	bind	VERB
dti-1335	369	29	protein-1	protein-1	PROPN
dti-1335	369	30	(	(	PUNCT
dti-1335	369	31	igfbp-1	igfbp-1	NOUN
dti-1335	369	32	)	)	PUNCT
dti-1335	369	33	transgenic	transgenic	NOUN
dti-1335	369	34	mice	mouse	NOUN
dti-1335	369	35	.	.	PUNCT
dti-1335	370	1	j.	j.	PROPN
dti-1335	370	2	neurosci	neurosci	PROPN
dti-1335	370	3	.	.	PROPN
dti-1335	370	4	,	,	PUNCT
dti-1335	370	5	15:7344–56	15:7344–56	NUM
dti-1335	370	6	.	.	PUNCT
dti-1335	371	1	zhu	zhu	PROPN
dti-1335	371	2	,	,	PUNCT
dti-1335	371	3	y.f	y.f	PROPN
dti-1335	371	4	.	.	PROPN
dti-1335	371	5	,	,	PUNCT
dti-1335	371	6	wang	wang	PROPN
dti-1335	371	7	,	,	PUNCT
dti-1335	371	8	x.c	x.c	PROPN
dti-1335	371	9	.	.	PROPN
dti-1335	371	10	,	,	PUNCT
dti-1335	371	11	connors	connor	NOUN
dti-1335	371	12	,	,	PUNCT
dti-1335	371	13	p.	p.	NOUN
dti-1335	371	14	et	et	NOUN
dti-1335	371	15	al	al	PROPN
dti-1335	371	16	.	.	PROPN
dti-1335	371	17	2003	2003	NUM
dti-1335	371	18	.	.	PUNCT
dti-1335	372	1	quinoline	quinoline	NOUN
dti-1335	372	2	-	-	PUNCT
dti-1335	372	3	carboxylic	carboxylic	ADJ
dti-1335	372	4	acids	acid	NOUN
dti-1335	372	5	are	be	AUX
dti-1335	372	6	potent	potent	ADJ
dti-1335	372	7	inhibitors	inhibitor	NOUN
dti-1335	372	8	that	that	PRON
dti-1335	372	9	inhibit	inhibit	VERB
dti-1335	372	10	the	the	DET
dti-1335	372	11	binding	bind	VERB
dti-1335	372	12	insulin	insulin	NOUN
dti-1335	372	13	-	-	PUNCT
dti-1335	372	14	like	like	ADJ
dti-1335	372	15	growth	growth	NOUN
dti-1335	372	16	factor	factor	NOUN
dti-1335	372	17	(	(	PUNCT
dti-1335	372	18	igf	igf	PROPN
dti-1335	372	19	)	)	PUNCT
dti-1335	372	20	to	to	ADP
dti-1335	372	21	igf	igf	NOUN
dti-1335	372	22	-	-	ADJ
dti-1335	372	23	binding	binding	ADJ
dti-1335	372	24	proteins	protein	NOUN
dti-1335	372	25	.	.	PUNCT
dti-1335	373	1	bioorganic	bioorganic	PROPN
dti-1335	373	2	.	.	PUNCT
dti-1335	374	1	med	med	PROPN
dti-1335	374	2	.	.	PROPN
dti-1335	374	3	chem	chem	PROPN
dti-1335	374	4	.	.	PUNCT
dti-1335	375	1	lett	lett	PROPN
dti-1335	375	2	.	.	PROPN
dti-1335	375	3	,	,	PUNCT
dti-1335	375	4	13:1931–4	13:1931–4	NUM
dti-1335	375	5	.	.	PUNCT
dti-1335	376	1	<	<	X
dti-1335	376	2	<	<	X
dti-1335	376	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1335	376	4	false	false	ADJ
dti-1335	376	5	/allowtransparency	/allowtransparency	NOUN
dti-1335	376	6	false	false	ADJ
dti-1335	376	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1335	376	8	true	true	ADJ
dti-1335	376	9	/autorotatepages	/autorotatepage	NOUN
dti-1335	376	10	/none	/none	PUNCT
dti-1335	376	11	/binding	/binding	PUNCT
dti-1335	376	12	/left	/left	ADJ
dti-1335	377	1	/calgrayprofile	/calgrayprofile	VERB
dti-1335	377	2	(	(	PUNCT
dti-1335	377	3	dot	dot	NOUN
dti-1335	377	4	gain	gain	NOUN
dti-1335	377	5	20	20	NUM
dti-1335	377	6	%	%	NOUN
dti-1335	377	7	)	)	PUNCT
dti-1335	377	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1335	378	1	(	(	PUNCT
dti-1335	378	2	srgb	srgb	PROPN
dti-1335	378	3	iec61966	iec61966	NOUN
dti-1335	378	4	-	-	PUNCT
dti-1335	378	5	2.1	2.1	NUM
dti-1335	378	6	)	)	PUNCT
dti-1335	378	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1335	379	1	(	(	PUNCT
dti-1335	379	2	u.s	u.s	PROPN
dti-1335	379	3	.	.	PROPN
dti-1335	379	4	web	web	NOUN
dti-1335	379	5	coated	coat	VERB
dti-1335	379	6	\050swop\051	\050swop\051	ADJ
dti-1335	379	7	v2	v2	NOUN
dti-1335	379	8	)	)	PUNCT
dti-1335	379	9	/srgbprofile	/srgbprofile	PUNCT
dti-1335	379	10	(	(	PUNCT
dti-1335	379	11	srgb	srgb	PROPN
dti-1335	379	12	iec61966	iec61966	NOUN
dti-1335	379	13	-	-	PUNCT
dti-1335	379	14	2.1	2.1	NUM
dti-1335	379	15	)	)	PUNCT
dti-1335	379	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1335	380	1	/error	/error	INTJ
dti-1335	380	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1335	381	1	1.4	1.4	NUM
dti-1335	381	2	/compressobjects	/compressobject	NOUN
dti-1335	381	3	/tags	/tag	VERB
dti-1335	381	4	/compresspages	/compresspage	NOUN
dti-1335	381	5	true	true	ADJ
dti-1335	381	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1335	381	7	true	true	ADJ
dti-1335	381	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1335	381	9	true	true	ADJ
dti-1335	381	10	/createjdffile	/createjdffile	ADJ
dti-1335	381	11	false	false	ADJ
dti-1335	381	12	/createjobticket	/createjobticket	NOUN
dti-1335	381	13	false	false	ADJ
dti-1335	381	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1335	381	15	/default	/default	PUNCT
dti-1335	381	16	/detectblends	/detectblend	NOUN
dti-1335	381	17	true	true	ADJ
dti-1335	381	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1335	381	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1335	381	20	/dothumbnails	/dothumbnail	VERB
dti-1335	381	21	false	false	ADJ
dti-1335	381	22	/embedallfonts	/embedallfont	NOUN
dti-1335	381	23	true	true	ADJ
dti-1335	381	24	/embedjoboptions	/embedjoboption	NOUN
dti-1335	381	25	true	true	ADJ
dti-1335	381	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1335	381	27	0	0	NUM
dti-1335	381	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1335	381	29	false	false	ADJ
dti-1335	381	30	/endpage	/endpage	NOUN
dti-1335	381	31	-1	-1	NOUN
dti-1335	381	32	/imagememory	/imagememory	NUM
dti-1335	382	1	1048576	1048576	NUM
dti-1335	382	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1335	382	3	false	false	ADJ
dti-1335	382	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1335	382	5	100	100	NUM
dti-1335	382	6	/optimize	/optimize	NOUN
dti-1335	382	7	true	true	ADJ
dti-1335	382	8	/opm	/opm	NOUN
dti-1335	382	9	1	1	NUM
dti-1335	382	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1335	382	11	true	true	ADJ
dti-1335	382	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1335	382	13	true	true	ADJ
dti-1335	382	14	/preservecopypage	/preservecopypage	NOUN
dti-1335	382	15	true	true	ADJ
dti-1335	382	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1335	382	17	true	true	ADJ
dti-1335	382	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1335	382	19	false	false	ADJ
dti-1335	382	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1335	382	21	false	false	ADJ
dti-1335	382	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1335	382	23	true	true	ADJ
dti-1335	382	24	/startpage	/startpage	NOUN
dti-1335	382	25	1	1	NUM
dti-1335	382	26	/subsetfonts	/subsetfont	NOUN
dti-1335	382	27	true	true	ADJ
dti-1335	382	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1335	382	29	/apply	/apply	PUNCT
dti-1335	382	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1335	383	1	/preserve	/preserve	NOUN
dti-1335	383	2	/useprologue	/useprologue	NOUN
dti-1335	383	3	false	false	ADJ
dti-1335	383	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1335	383	5	(	(	PUNCT
dti-1335	383	6	)	)	PUNCT
dti-1335	383	7	/alwaysembed	/alwaysembe	VERB
dti-1335	383	8	[	[	PUNCT
dti-1335	383	9	true	true	ADJ
dti-1335	383	10	]	]	PUNCT
dti-1335	383	11	/neverembed	/neverembed	PUNCT
dti-1335	384	1	[	[	PUNCT
dti-1335	384	2	true	true	ADJ
dti-1335	384	3	]	]	PUNCT
dti-1335	384	4	/antialiascolorimages	/antialiascolorimages	X
dti-1335	384	5	false	false	ADJ
dti-1335	384	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1335	384	7	true	true	ADJ
dti-1335	384	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1335	384	9	/bicubic	/bicubic	NOUN
dti-1335	384	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1335	384	11	300	300	NUM
dti-1335	384	12	/colorimagedepth	/colorimagedepth	PRON
dti-1335	385	1	-1	-1	INTJ
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dti-1335	385	5	true	true	ADJ
dti-1335	385	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1335	385	7	/dctencode	/dctencode	PUNCT
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dti-1335	385	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1335	385	11	/jpeg	/jpeg	PUNCT
dti-1335	385	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1335	386	1	<	<	X
dti-1335	386	2	<	<	X
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dti-1335	387	3	1	1	NUM
dti-1335	387	4	1	1	NUM
dti-1335	387	5	1	1	NUM
dti-1335	387	6	]	]	PUNCT
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dti-1335	388	2	1	1	NUM
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dti-1335	388	5	1	1	NUM
dti-1335	388	6	]	]	PUNCT
dti-1335	388	7	>	>	PUNCT
dti-1335	388	8	>	>	X
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dti-1335	390	2	1	1	NUM
dti-1335	390	3	1	1	NUM
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dti-1335	390	6	]	]	PUNCT
dti-1335	390	7	/vsamples	/vsample	NOUN
dti-1335	391	1	[	[	X
dti-1335	391	2	1	1	NUM
dti-1335	391	3	1	1	NUM
dti-1335	391	4	1	1	NUM
dti-1335	391	5	1	1	NUM
dti-1335	391	6	]	]	PUNCT
dti-1335	391	7	>	>	PUNCT
dti-1335	391	8	>	>	X
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dti-1335	408	4	/deu	/deu	PUNCT
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dti-1335	409	3	>	>	X
dti-1335	409	4	/ptb	/ptb	PROPN
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dti-1335	411	2	>	>	X
dti-1335	411	3	/dan	/dan	PUNCT
dti-1335	412	1	<	<	X
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dti-1335	412	3	>	>	X
dti-1335	412	4	/nld	/nld	PUNCT
dti-1335	413	1	<	<	X
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dti-1335	413	3	>	>	X
dti-1335	413	4	/esp	/esp	PUNCT
dti-1335	414	1	<	<	X
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dti-1335	414	3	>	>	X
dti-1335	414	4	/suo	/suo	PUNCT
dti-1335	415	1	<	<	X
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dti-1335	415	3	>	>	X
dti-1335	415	4	/ita	/ita	PUNCT
dti-1335	416	1	<	<	X
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dti-1335	416	3	>	>	X
dti-1335	416	4	/nor	/nor	X
dti-1335	416	5	<	<	X
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dti-1335	416	7	>	>	X
dti-1335	416	8	/sve	/sve	NOUN
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dti-1335	417	4	/enu	/enu	PROPN
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dti-1335	417	12	setdistillerparams	setdistillerparam	NOUN
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dti-1335	418	3	/hwresolution	/hwresolution	NOUN
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dti-1335	419	5	/pagesize	/pagesize	X
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dti-1335	420	7	setpagedevice	setpagedevice	PROPN