id	sid	tid	token	lemma	pos
dti-1336	1	1	zangari	zangari	PROPN
dti-1336	1	2	et	et	PROPN
dti-1336	1	3	al.indd	al.indd	X
dti-1336	1	4	drug	drug	NOUN
dti-1336	1	5	target	target	NOUN
dti-1336	1	6	insights	insight	NOUN
dti-1336	1	7	2008:3	2008:3	NUM
dti-1336	1	8	87–97	87–97	NUM
dti-1336	1	9	87	87	NUM
dti-1336	1	10	review	review	NOUN
dti-1336	1	11	correspondence	correspondence	NOUN
dti-1336	1	12	:	:	PUNCT
dti-1336	1	13	maurizio	maurizio	PROPN
dti-1336	1	14	zangari	zangari	PROPN
dti-1336	1	15	,	,	PUNCT
dti-1336	1	16	m.d	m.d	PROPN
dti-1336	1	17	.	.	PROPN
dti-1336	1	18	,	,	PUNCT
dti-1336	1	19	30	30	NUM
dti-1336	1	20	north	north	NOUN
dti-1336	1	21	1900	1900	NUM
dti-1336	1	22	east	east	NOUN
dti-1336	1	23	,	,	PUNCT
dti-1336	1	24	som	som	NOUN
dti-1336	1	25	room	room	NOUN
dti-1336	1	26	5c402	5c402	NUM
dti-1336	1	27	,	,	PUNCT
dti-1336	1	28	salt	salt	NOUN
dti-1336	1	29	lake	lake	PROPN
dti-1336	1	30	city	city	PROPN
dti-1336	1	31	,	,	PUNCT
dti-1336	1	32	utah	utah	PROPN
dti-1336	1	33	,	,	PUNCT
dti-1336	1	34	84132	84132	NUM
dti-1336	1	35	.	.	PUNCT
dti-1336	2	1	tel	tel	ADP
dti-1336	2	2	:	:	PUNCT
dti-1336	2	3	801	801	NUM
dti-1336	2	4	-	-	NUM
dti-1336	2	5	585	585	NUM
dti-1336	2	6	-	-	NUM
dti-1336	2	7	3229	3229	NUM
dti-1336	2	8	;	;	PUNCT
dti-1336	2	9	fax	fax	NOUN
dti-1336	2	10	:	:	PUNCT
dti-1336	2	11	801	801	NUM
dti-1336	2	12	-	-	NUM
dti-1336	2	13	585	585	NUM
dti-1336	2	14	-	-	SYM
dti-1336	2	15	3432	3432	NUM
dti-1336	2	16	;	;	PUNCT
dti-1336	2	17	email	email	NOUN
dti-1336	2	18	:	:	PUNCT
dti-1336	2	19	maurizio.zangari@hsc.utah.edu	maurizio.zangari@hsc.utah.edu	NUM
dti-1336	2	20	copyright	copyright	NOUN
dti-1336	2	21	in	in	ADP
dti-1336	2	22	this	this	DET
dti-1336	2	23	article	article	NOUN
dti-1336	2	24	,	,	PUNCT
dti-1336	2	25	its	its	PRON
dti-1336	2	26	metadata	metadata	NOUN
dti-1336	2	27	,	,	PUNCT
dti-1336	2	28	and	and	CCONJ
dti-1336	2	29	any	any	DET
dti-1336	2	30	supplementary	supplementary	ADJ
dti-1336	2	31	data	datum	NOUN
dti-1336	2	32	is	be	AUX
dti-1336	2	33	held	hold	VERB
dti-1336	2	34	by	by	ADP
dti-1336	2	35	its	its	PRON
dti-1336	2	36	author	author	NOUN
dti-1336	2	37	or	or	CCONJ
dti-1336	2	38	authors	author	NOUN
dti-1336	2	39	.	.	PUNCT
dti-1336	3	1	it	it	PRON
dti-1336	3	2	is	be	AUX
dti-1336	3	3	published	publish	VERB
dti-1336	3	4	under	under	ADP
dti-1336	3	5	the	the	DET
dti-1336	3	6	creative	creative	ADJ
dti-1336	3	7	commons	common	NOUN
dti-1336	3	8	attribution	attribution	NOUN
dti-1336	3	9	by	by	ADP
dti-1336	3	10	licence	licence	NOUN
dti-1336	3	11	.	.	PUNCT
dti-1336	4	1	for	for	SCONJ
dti-1336	4	2	further	further	ADJ
dti-1336	4	3	information	information	NOUN
dti-1336	4	4	go	go	VERB
dti-1336	4	5	to	to	ADP
dti-1336	4	6	:	:	PUNCT
dti-1336	4	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	NOUN
dti-1336	4	8	thrombophilia	thrombophilia	PROPN
dti-1336	4	9	maurizio	maurizio	PROPN
dti-1336	4	10	zangari1	zangari1	PROPN
dti-1336	4	11	,	,	PUNCT
dti-1336	4	12	francesca	francesca	PROPN
dti-1336	4	13	elice2	elice2	PROPN
dti-1336	4	14	,	,	PUNCT
dti-1336	4	15	guido	guido	NOUN
dti-1336	4	16	tricot1	tricot1	PROPN
dti-1336	4	17	and	and	CCONJ
dti-1336	4	18	louis	louis	PROPN
dti-1336	4	19	fink3	fink3	PROPN
dti-1336	4	20	1university	1university	NUM
dti-1336	4	21	of	of	ADP
dti-1336	4	22	utah	utah	PROPN
dti-1336	4	23	school	school	NOUN
dti-1336	4	24	of	of	ADP
dti-1336	4	25	medicine	medicine	NOUN
dti-1336	4	26	,	,	PUNCT
dti-1336	4	27	department	department	NOUN
dti-1336	4	28	of	of	ADP
dti-1336	4	29	hematology	hematology	NOUN
dti-1336	4	30	,	,	PUNCT
dti-1336	4	31	blood	blood	NOUN
dti-1336	4	32	/	/	SYM
dti-1336	4	33	marrow	marrow	NOUN
dti-1336	4	34	transplant	transplant	NOUN
dti-1336	4	35	and	and	CCONJ
dti-1336	4	36	myeloma	myeloma	NOUN
dti-1336	4	37	,	,	PUNCT
dti-1336	4	38	salt	salt	NOUN
dti-1336	4	39	lake	lake	PROPN
dti-1336	4	40	city	city	PROPN
dti-1336	4	41	,	,	PUNCT
dti-1336	4	42	ut	ut	PROPN
dti-1336	4	43	,	,	PUNCT
dti-1336	4	44	u.s.a	u.s.a	PROPN
dti-1336	4	45	.	.	PUNCT
dti-1336	5	1	2department	2department	NUM
dti-1336	5	2	of	of	ADP
dti-1336	5	3	hematology	hematology	NOUN
dti-1336	5	4	,	,	PUNCT
dti-1336	5	5	san	san	PROPN
dti-1336	5	6	bortolo	bortolo	PROPN
dti-1336	5	7	hospital	hospital	NOUN
dti-1336	5	8	,	,	PUNCT
dti-1336	5	9	vicenza	vicenza	PROPN
dti-1336	5	10	,	,	PUNCT
dti-1336	5	11	italy	italy	PROPN
dti-1336	5	12	.	.	PUNCT
dti-1336	6	1	3nevada	3nevada	NUM
dti-1336	6	2	cancer	cancer	PROPN
dti-1336	6	3	institute	institute	PROPN
dti-1336	6	4	,	,	PUNCT
dti-1336	6	5	las	las	PROPN
dti-1336	6	6	vegas	vegas	PROPN
dti-1336	6	7	,	,	PUNCT
dti-1336	6	8	nevada	nevada	PROPN
dti-1336	6	9	,	,	PUNCT
dti-1336	6	10	u.s.a	u.s.a	PROPN
dti-1336	6	11	.	.	PUNCT
dti-1336	6	12	thrombophilia	thrombophilia	PROPN
dti-1336	6	13	or	or	CCONJ
dti-1336	6	14	hypercoagulable	hypercoagulable	ADJ
dti-1336	6	15	state	state	NOUN
dti-1336	6	16	is	be	AUX
dti-1336	6	17	a	a	DET
dti-1336	6	18	clinical	clinical	ADJ
dti-1336	6	19	condition	condition	NOUN
dti-1336	6	20	characterized	characterize	VERB
dti-1336	6	21	by	by	ADP
dti-1336	6	22	a	a	DET
dti-1336	6	23	tendency	tendency	NOUN
dti-1336	6	24	to	to	PART
dti-1336	6	25	develop	develop	VERB
dti-1336	6	26	venous	venous	ADJ
dti-1336	6	27	and	and	CCONJ
dti-1336	6	28	(	(	PUNCT
dti-1336	6	29	less	less	ADV
dti-1336	6	30	frequently	frequently	ADV
dti-1336	6	31	)	)	PUNCT
dti-1336	6	32	arterial	arterial	ADJ
dti-1336	6	33	thrombosis	thrombosis	NOUN
dti-1336	6	34	.	.	PUNCT
dti-1336	7	1	thrombosis	thrombosis	NOUN
dti-1336	7	2	is	be	AUX
dti-1336	7	3	defi	defi	NOUN
dti-1336	7	4	ned	ned	NOUN
dti-1336	7	5	as	as	ADP
dti-1336	7	6	the	the	DET
dti-1336	7	7	obstructive	obstructive	ADJ
dti-1336	7	8	clot	clot	NOUN
dti-1336	7	9	formation	formation	NOUN
dti-1336	7	10	within	within	ADP
dti-1336	7	11	a	a	DET
dti-1336	7	12	vessel	vessel	NOUN
dti-1336	7	13	.	.	PUNCT
dti-1336	8	1	since	since	SCONJ
dti-1336	8	2	the	the	DET
dti-1336	8	3	fi	fi	NOUN
dti-1336	8	4	rst	rst	ADJ
dti-1336	8	5	observation	observation	NOUN
dti-1336	8	6	of	of	ADP
dti-1336	8	7	virchow	virchow	NOUN
dti-1336	8	8	,	,	PUNCT
dti-1336	8	9	three	three	NUM
dti-1336	8	10	major	major	ADJ
dti-1336	8	11	pathogenic	pathogenic	ADJ
dti-1336	8	12	causes	cause	NOUN
dti-1336	8	13	of	of	ADP
dti-1336	8	14	thrombosis	thrombosis	NOUN
dti-1336	8	15	have	have	AUX
dti-1336	8	16	been	be	AUX
dti-1336	8	17	identifi	identifi	ADJ
dti-1336	8	18	ed	ed	NOUN
dti-1336	8	19	:	:	PUNCT
dti-1336	8	20	changes	change	NOUN
dti-1336	8	21	in	in	ADP
dti-1336	8	22	the	the	DET
dti-1336	8	23	vessel	vessel	NOUN
dti-1336	8	24	wall	wall	NOUN
dti-1336	8	25	,	,	PUNCT
dti-1336	8	26	in	in	ADP
dti-1336	8	27	the	the	DET
dti-1336	8	28	blood	blood	NOUN
dti-1336	9	1	fl	fl	INTJ
dti-1336	10	1	ow	ow	INTJ
dti-1336	10	2	and	and	CCONJ
dti-1336	10	3	in	in	ADP
dti-1336	10	4	the	the	DET
dti-1336	10	5	blood	blood	NOUN
dti-1336	10	6	composition	composition	NOUN
dti-1336	10	7	.	.	PUNCT
dti-1336	11	1	although	although	SCONJ
dti-1336	11	2	all	all	DET
dti-1336	11	3	these	these	DET
dti-1336	11	4	mechanisms	mechanism	NOUN
dti-1336	11	5	may	may	AUX
dti-1336	11	6	contribute	contribute	VERB
dti-1336	11	7	to	to	ADP
dti-1336	11	8	thrombosis	thrombosis	NOUN
dti-1336	11	9	,	,	PUNCT
dti-1336	11	10	arterial	arterial	ADJ
dti-1336	11	11	events	event	NOUN
dti-1336	11	12	are	be	AUX
dti-1336	11	13	mainly	mainly	ADV
dti-1336	11	14	determined	determine	VERB
dti-1336	11	15	by	by	ADP
dti-1336	11	16	changes	change	NOUN
dti-1336	11	17	in	in	ADP
dti-1336	11	18	the	the	DET
dti-1336	11	19	vessel	vessel	NOUN
dti-1336	11	20	wall	wall	NOUN
dti-1336	11	21	,	,	PUNCT
dti-1336	11	22	in	in	ADP
dti-1336	11	23	particular	particular	ADJ
dti-1336	11	24	atherosclerosis	atherosclerosis	NOUN
dti-1336	11	25	,	,	PUNCT
dti-1336	11	26	while	while	SCONJ
dti-1336	11	27	stasis	stasis	NOUN
dti-1336	11	28	and	and	CCONJ
dti-1336	11	29	prothrombotic	prothrombotic	ADJ
dti-1336	11	30	blood	blood	NOUN
dti-1336	11	31	abnormalities	abnormality	NOUN
dti-1336	11	32	play	play	VERB
dti-1336	11	33	a	a	DET
dti-1336	11	34	major	major	ADJ
dti-1336	11	35	role	role	NOUN
dti-1336	11	36	in	in	ADP
dti-1336	11	37	venous	venous	ADJ
dti-1336	11	38	thrombosis	thrombosis	NOUN
dti-1336	11	39	.	.	PUNCT
dti-1336	12	1	venous	venous	ADJ
dti-1336	12	2	thrombosis	thrombosis	NOUN
dti-1336	12	3	is	be	AUX
dti-1336	12	4	a	a	DET
dti-1336	12	5	sudden	sudden	ADJ
dti-1336	12	6	event	event	NOUN
dti-1336	12	7	that	that	PRON
dti-1336	12	8	occurs	occur	VERB
dti-1336	12	9	during	during	ADP
dti-1336	12	10	a	a	DET
dti-1336	12	11	shortor	shortor	NOUN
dti-1336	12	12	long	long	ADV
dti-1336	12	13	-	-	PUNCT
dti-1336	12	14	lasting	last	VERB
dti-1336	12	15	period	period	NOUN
dti-1336	12	16	of	of	ADP
dti-1336	12	17	increased	increase	VERB
dti-1336	12	18	risk	risk	NOUN
dti-1336	12	19	,	,	PUNCT
dti-1336	12	20	but	but	CCONJ
dti-1336	12	21	clinical	clinical	ADJ
dti-1336	12	22	symptoms	symptom	NOUN
dti-1336	12	23	may	may	AUX
dti-1336	12	24	sometimes	sometimes	ADV
dti-1336	12	25	be	be	AUX
dti-1336	12	26	mild	mild	ADJ
dti-1336	12	27	,	,	PUNCT
dti-1336	12	28	leading	lead	VERB
dti-1336	12	29	to	to	ADP
dti-1336	12	30	diagnostic	diagnostic	ADJ
dti-1336	12	31	diffi	diffi	NOUN
dti-1336	12	32	culties	cultie	NOUN
dti-1336	12	33	.	.	PUNCT
dti-1336	13	1	the	the	DET
dti-1336	13	2	development	development	NOUN
dti-1336	13	3	of	of	ADP
dti-1336	13	4	a	a	DET
dti-1336	13	5	venous	venous	ADJ
dti-1336	13	6	thromboembolic	thromboembolic	NOUN
dti-1336	13	7	episode	episode	NOUN
dti-1336	13	8	(	(	PUNCT
dti-1336	13	9	vte	vte	NOUN
dti-1336	13	10	)	)	PUNCT
dti-1336	13	11	is	be	AUX
dti-1336	13	12	often	often	ADV
dti-1336	13	13	the	the	DET
dti-1336	13	14	result	result	NOUN
dti-1336	13	15	of	of	ADP
dti-1336	13	16	multiple	multiple	ADJ
dti-1336	13	17	risk	risk	NOUN
dti-1336	13	18	factors	factor	NOUN
dti-1336	13	19	,	,	PUNCT
dti-1336	13	20	including	include	VERB
dti-1336	13	21	both	both	CCONJ
dti-1336	13	22	congenital	congenital	ADJ
dti-1336	13	23	procoagulant	procoagulant	NOUN
dti-1336	13	24	defects	defect	NOUN
dti-1336	13	25	and	and	CCONJ
dti-1336	13	26	enviromental	enviromental	ADJ
dti-1336	13	27	factors	factor	NOUN
dti-1336	13	28	such	such	ADJ
dti-1336	13	29	as	as	ADP
dti-1336	13	30	age	age	NOUN
dti-1336	13	31	,	,	PUNCT
dti-1336	13	32	male	male	ADJ
dti-1336	13	33	sex	sex	NOUN
dti-1336	13	34	,	,	PUNCT
dti-1336	13	35	obesity	obesity	NOUN
dti-1336	13	36	,	,	PUNCT
dti-1336	13	37	exposure	exposure	NOUN
dti-1336	13	38	to	to	ADP
dti-1336	13	39	“	"	PUNCT
dti-1336	13	40	risk	risk	NOUN
dti-1336	13	41	periods	period	NOUN
dti-1336	13	42	”	"	PUNCT
dti-1336	13	43	of	of	ADP
dti-1336	13	44	immobilization	immobilization	NOUN
dti-1336	13	45	,	,	PUNCT
dti-1336	13	46	trauma	trauma	NOUN
dti-1336	13	47	,	,	PUNCT
dti-1336	13	48	cancer	cancer	NOUN
dti-1336	13	49	,	,	PUNCT
dti-1336	13	50	pregnancy	pregnancy	NOUN
dti-1336	13	51	,	,	PUNCT
dti-1336	13	52	use	use	NOUN
dti-1336	13	53	of	of	ADP
dti-1336	13	54	exogenous	exogenous	ADJ
dti-1336	13	55	hormones	hormone	NOUN
dti-1336	13	56	or	or	CCONJ
dti-1336	13	57	chemotherapy	chemotherapy	NOUN
dti-1336	13	58	.	.	PUNCT
dti-1336	14	1	hereditary	hereditary	ADJ
dti-1336	14	2	thrombophilia	thrombophilia	NOUN
dti-1336	14	3	is	be	AUX
dti-1336	14	4	a	a	DET
dti-1336	14	5	genetically	genetically	ADV
dti-1336	14	6	determined	determine	VERB
dti-1336	14	7	increased	increase	VERB
dti-1336	14	8	risk	risk	NOUN
dti-1336	14	9	of	of	ADP
dti-1336	14	10	thrombosis	thrombosis	NOUN
dti-1336	14	11	;	;	PUNCT
dti-1336	14	12	acquired	acquire	VERB
dti-1336	14	13	or	or	CCONJ
dti-1336	14	14	secondary	secondary	ADJ
dti-1336	14	15	thrombophilia	thrombophilia	NOUN
dti-1336	14	16	is	be	AUX
dti-1336	14	17	a	a	DET
dti-1336	14	18	physiologic	physiologic	ADJ
dti-1336	14	19	or	or	CCONJ
dti-1336	14	20	pathologic	pathologic	ADJ
dti-1336	14	21	condition	condition	NOUN
dti-1336	14	22	that	that	PRON
dti-1336	14	23	predispose	predispose	VERB
dti-1336	14	24	affected	affected	ADJ
dti-1336	14	25	persons	person	NOUN
dti-1336	14	26	to	to	ADP
dti-1336	14	27	thromboembolic	thromboembolic	NOUN
dti-1336	14	28	diseases	disease	NOUN
dti-1336	14	29	.	.	PUNCT
dti-1336	15	1	hereditary	hereditary	ADJ
dti-1336	15	2	thrombophilia	thrombophilia	NOUN
dti-1336	15	3	should	should	AUX
dti-1336	15	4	be	be	AUX
dti-1336	15	5	suspected	suspect	VERB
dti-1336	15	6	in	in	ADP
dti-1336	15	7	persons	person	NOUN
dti-1336	15	8	with	with	ADP
dti-1336	15	9	a	a	DET
dti-1336	15	10	family	family	NOUN
dti-1336	15	11	history	history	NOUN
dti-1336	15	12	of	of	ADP
dti-1336	15	13	thrombosis	thrombosis	NOUN
dti-1336	15	14	,	,	PUNCT
dti-1336	15	15	especially	especially	ADV
dti-1336	15	16	if	if	SCONJ
dti-1336	15	17	the	the	DET
dti-1336	15	18	thrombotic	thrombotic	ADJ
dti-1336	15	19	events	event	NOUN
dti-1336	15	20	occurred	occur	VERB
dti-1336	15	21	in	in	ADP
dti-1336	15	22	young	young	ADJ
dti-1336	15	23	patients	patient	NOUN
dti-1336	15	24	or	or	CCONJ
dti-1336	15	25	when	when	SCONJ
dti-1336	15	26	trigger	trigger	NOUN
dti-1336	15	27	factors	factor	NOUN
dti-1336	15	28	are	be	AUX
dti-1336	15	29	absent	absent	ADJ
dti-1336	15	30	or	or	CCONJ
dti-1336	15	31	minimal	minimal	ADJ
dti-1336	15	32	.	.	PUNCT
dti-1336	16	1	a	a	DET
dti-1336	16	2	congenital	congenital	ADJ
dti-1336	16	3	or	or	CCONJ
dti-1336	16	4	acquired	acquire	VERB
dti-1336	16	5	hypercoagulable	hypercoagulable	ADJ
dti-1336	16	6	state	state	NOUN
dti-1336	16	7	should	should	AUX
dti-1336	16	8	also	also	ADV
dti-1336	16	9	be	be	AUX
dti-1336	16	10	suspected	suspect	VERB
dti-1336	16	11	in	in	ADP
dti-1336	16	12	the	the	DET
dti-1336	16	13	case	case	NOUN
dti-1336	16	14	of	of	ADP
dti-1336	16	15	idiopathic	idiopathic	ADJ
dti-1336	16	16	recurrent	recurrent	ADJ
dti-1336	16	17	vte	vte	NOUN
dti-1336	16	18	or	or	CCONJ
dti-1336	16	19	in	in	ADP
dti-1336	16	20	thrombosis	thrombosis	NOUN
dti-1336	16	21	involving	involve	VERB
dti-1336	16	22	atypical	atypical	ADJ
dti-1336	16	23	locations	location	NOUN
dti-1336	16	24	,	,	PUNCT
dti-1336	16	25	like	like	ADP
dti-1336	16	26	upper	upper	ADJ
dti-1336	16	27	extremities	extremity	NOUN
dti-1336	16	28	,	,	PUNCT
dti-1336	16	29	visceral	visceral	ADJ
dti-1336	16	30	veins	vein	NOUN
dti-1336	16	31	(	(	PUNCT
dti-1336	16	32	hepatic	hepatic	ADJ
dti-1336	16	33	,	,	PUNCT
dti-1336	16	34	portal	portal	ADJ
dti-1336	16	35	,	,	PUNCT
dti-1336	16	36	mesenteric	mesenteric	ADJ
dti-1336	16	37	)	)	PUNCT
dti-1336	16	38	or	or	CCONJ
dti-1336	16	39	cerebral	cerebral	ADJ
dti-1336	16	40	veins.1	veins.1	NOUN
dti-1336	16	41	table	table	NOUN
dti-1336	16	42	1	1	NUM
dti-1336	16	43	summarizes	summarize	NOUN
dti-1336	16	44	the	the	DET
dti-1336	16	45	most	most	ADV
dti-1336	16	46	frequently	frequently	ADV
dti-1336	16	47	inherited	inherit	VERB
dti-1336	16	48	and	and	CCONJ
dti-1336	16	49	acquired	acquire	VERB
dti-1336	16	50	thrombophilic	thrombophilic	ADJ
dti-1336	16	51	conditions	condition	NOUN
dti-1336	16	52	in	in	ADP
dti-1336	16	53	a	a	DET
dti-1336	16	54	population	population	NOUN
dti-1336	16	55	of	of	ADP
dti-1336	16	56	patients	patient	NOUN
dti-1336	16	57	with	with	ADP
dti-1336	16	58	a	a	DET
dti-1336	16	59	fi	fi	NOUN
dti-1336	16	60	rst	rst	PROPN
dti-1336	16	61	episode	episode	NOUN
dti-1336	16	62	of	of	ADP
dti-1336	16	63	vte	vte	NOUN
dti-1336	16	64	.	.	PUNCT
dti-1336	17	1	in	in	ADP
dti-1336	17	2	patients	patient	NOUN
dti-1336	17	3	with	with	ADP
dti-1336	17	4	venous	venous	ADJ
dti-1336	17	5	thrombosis	thrombosis	NOUN
dti-1336	17	6	before	before	ADP
dti-1336	17	7	the	the	DET
dti-1336	17	8	early	early	ADJ
dti-1336	17	9	nineteen	nineteen	NUM
dti-1336	17	10	-	-	PUNCT
dti-1336	17	11	ninties	nintie	NOUN
dti-1336	17	12	a	a	DET
dti-1336	17	13	biologic	biologic	NOUN
dti-1336	17	14	cause	cause	NOUN
dti-1336	17	15	of	of	ADP
dti-1336	17	16	thrombophilia	thrombophilia	NOUN
dti-1336	17	17	was	be	AUX
dti-1336	17	18	detectable	detectable	ADJ
dti-1336	17	19	in	in	ADP
dti-1336	17	20	only	only	ADV
dti-1336	17	21	5	5	NUM
dti-1336	17	22	%	%	NOUN
dti-1336	17	23	to	to	PART
dti-1336	17	24	15	15	NUM
dti-1336	17	25	%	%	NOUN
dti-1336	17	26	of	of	ADP
dti-1336	17	27	cases	case	NOUN
dti-1336	17	28	and	and	CCONJ
dti-1336	17	29	was	be	AUX
dti-1336	17	30	confi	confi	VERB
dti-1336	17	31	ned	ned	ADJ
dti-1336	17	32	to	to	ADP
dti-1336	17	33	defi	defi	PROPN
dti-1336	17	34	ciencies	ciencie	NOUN
dti-1336	17	35	of	of	ADP
dti-1336	17	36	antithrombin	antithrombin	PROPN
dti-1336	17	37	,	,	PUNCT
dti-1336	17	38	protein	protein	NOUN
dti-1336	17	39	c	c	NOUN
dti-1336	17	40	,	,	PUNCT
dti-1336	17	41	and	and	CCONJ
dti-1336	17	42	protein	protein	NOUN
dti-1336	17	43	s.	s.	PROPN
dti-1336	17	44	the	the	DET
dti-1336	17	45	discovery	discovery	PROPN
dti-1336	17	46	of	of	ADP
dti-1336	17	47	two	two	NUM
dti-1336	17	48	prothrombotic	prothrombotic	ADJ
dti-1336	17	49	mutations	mutation	NOUN
dti-1336	17	50	prevalent	prevalent	ADJ
dti-1336	17	51	in	in	ADP
dti-1336	17	52	white	white	ADJ
dti-1336	17	53	populations	population	NOUN
dti-1336	17	54	,	,	PUNCT
dti-1336	17	55	the	the	DET
dti-1336	17	56	factor	factor	NOUN
dti-1336	17	57	v	v	NOUN
dti-1336	17	58	-	-	PUNCT
dti-1336	17	59	arg506gln	arg506gln	NOUN
dti-1336	17	60	mutation	mutation	NOUN
dti-1336	17	61	(	(	PUNCT
dti-1336	17	62	factor	factor	NOUN
dti-1336	17	63	v	v	NOUN
dti-1336	17	64	leiden	leiden	PROPN
dti-1336	17	65	)	)	PUNCT
dti-1336	17	66	and	and	CCONJ
dti-1336	17	67	the	the	DET
dti-1336	17	68	prothrombin	prothrombin	NOUN
dti-1336	17	69	g20210a	g20210a	X
dti-1336	17	70	mutation	mutation	NOUN
dti-1336	17	71	has	have	AUX
dti-1336	17	72	signifi	signifi	NOUN
dti-1336	17	73	cantly	cantly	ADV
dti-1336	17	74	increased	increase	VERB
dti-1336	17	75	the	the	DET
dti-1336	17	76	number	number	NOUN
dti-1336	17	77	of	of	ADP
dti-1336	17	78	patients	patient	NOUN
dti-1336	17	79	with	with	ADP
dti-1336	17	80	recognizable	recognizable	ADJ
dti-1336	17	81	hereditary	hereditary	ADJ
dti-1336	17	82	risk	risk	NOUN
dti-1336	17	83	factor	factor	NOUN
dti-1336	17	84	.	.	PUNCT
dti-1336	18	1	factor	factor	NOUN
dti-1336	18	2	v	v	PROPN
dti-1336	18	3	leiden	leiden	PROPN
dti-1336	18	4	mutationis	mutationis	PROPN
dti-1336	18	5	apparently	apparently	ADV
dti-1336	18	6	not	not	PART
dti-1336	18	7	present	present	ADJ
dti-1336	18	8	in	in	ADP
dti-1336	18	9	african	african	ADJ
dti-1336	18	10	blacks	black	NOUN
dti-1336	18	11	,	,	PUNCT
dti-1336	18	12	japanese	japanese	ADJ
dti-1336	18	13	or	or	CCONJ
dti-1336	18	14	native	native	ADJ
dti-1336	18	15	american	american	ADJ
dti-1336	18	16	populations	population	NOUN
dti-1336	18	17	and	and	CCONJ
dti-1336	18	18	less	less	ADJ
dti-1336	18	19	than	than	ADP
dti-1336	18	20	1	1	NUM
dti-1336	18	21	%	%	NOUN
dti-1336	18	22	in	in	ADP
dti-1336	18	23	chinese.24	chinese.24	NOUN
dti-1336	18	24	the	the	DET
dti-1336	18	25	incidence	incidence	NOUN
dti-1336	18	26	of	of	ADP
dti-1336	18	27	vte	vte	NOUN
dti-1336	18	28	is	be	AUX
dti-1336	18	29	higher	high	ADJ
dti-1336	18	30	in	in	ADP
dti-1336	18	31	africans	africans	PROPN
dti-1336	18	32	and	and	CCONJ
dti-1336	18	33	lower	low	ADJ
dti-1336	18	34	in	in	ADP
dti-1336	18	35	asian	asian	ADJ
dti-1336	18	36	populations	population	NOUN
dti-1336	18	37	,	,	PUNCT
dti-1336	18	38	however	however	ADV
dti-1336	18	39	,	,	PUNCT
dti-1336	18	40	the	the	DET
dti-1336	18	41	prevalence	prevalence	NOUN
dti-1336	18	42	of	of	ADP
dti-1336	18	43	hereditary	hereditary	ADJ
dti-1336	18	44	or	or	CCONJ
dti-1336	18	45	acquired	acquire	VERB
dti-1336	18	46	thrombophilic	thrombophilic	ADJ
dti-1336	18	47	factors	factor	NOUN
dti-1336	18	48	in	in	ADP
dti-1336	18	49	these	these	DET
dti-1336	18	50	ethnic	ethnic	ADJ
dti-1336	18	51	groups	group	NOUN
dti-1336	18	52	is	be	AUX
dti-1336	18	53	less	less	ADV
dti-1336	18	54	known	known	ADJ
dti-1336	18	55	.	.	PUNCT
dti-1336	19	1	hereditary	hereditary	ADJ
dti-1336	19	2	thrombophilia	thrombophilia	NOUN
dti-1336	19	3	the	the	DET
dti-1336	19	4	most	most	ADV
dti-1336	19	5	common	common	ADJ
dti-1336	19	6	inherited	inherit	VERB
dti-1336	19	7	defects	defect	NOUN
dti-1336	19	8	include	include	VERB
dti-1336	19	9	activated	activate	VERB
dti-1336	19	10	protein	protein	NOUN
dti-1336	19	11	c	c	NOUN
dti-1336	19	12	resistance	resistance	NOUN
dti-1336	19	13	caused	cause	VERB
dti-1336	19	14	by	by	ADP
dti-1336	19	15	the	the	DET
dti-1336	19	16	factor	factor	NOUN
dti-1336	19	17	v	v	PROPN
dti-1336	19	18	leiden	leiden	PROPN
dti-1336	19	19	mutation	mutation	PROPN
dti-1336	19	20	,	,	PUNCT
dti-1336	19	21	the	the	DET
dti-1336	19	22	prothrombin	prothrombin	ADJ
dti-1336	19	23	gene	gene	NOUN
dti-1336	19	24	g20210a	g20210a	NOUN
dti-1336	19	25	mutation	mutation	NOUN
dti-1336	19	26	and	and	CCONJ
dti-1336	19	27	hyperhomocysteinemia	hyperhomocysteinemia	NOUN
dti-1336	19	28	.	.	PUNCT
dti-1336	20	1	less	less	ADJ
dti-1336	20	2	common	common	ADJ
dti-1336	20	3	disorders	disorder	NOUN
dti-1336	20	4	include	include	VERB
dti-1336	20	5	defi	defi	NOUN
dti-1336	20	6	ciencies	ciencie	NOUN
dti-1336	20	7	of	of	ADP
dti-1336	20	8	antithrombin	antithrombin	PROPN
dti-1336	20	9	,	,	PUNCT
dti-1336	20	10	protein	protein	NOUN
dti-1336	20	11	c	c	NOUN
dti-1336	20	12	,	,	PUNCT
dti-1336	20	13	protein	protein	NOUN
dti-1336	20	14	s	s	NOUN
dti-1336	20	15	,	,	PUNCT
dti-1336	20	16	plasminogen	plasminogen	NOUN
dti-1336	20	17	and	and	CCONJ
dti-1336	20	18	dysfi	dysfi	PROPN
dti-1336	20	19	brinogenemias	brinogenemias	PROPN
dti-1336	20	20	.	.	PUNCT
dti-1336	21	1	these	these	DET
dti-1336	21	2	thrombophilic	thrombophilic	ADJ
dti-1336	21	3	defects	defect	NOUN
dti-1336	21	4	either	either	CCONJ
dti-1336	21	5	enhancing	enhance	VERB
dti-1336	21	6	procoagulant	procoagulant	ADJ
dti-1336	21	7	reactions	reaction	NOUN
dti-1336	21	8	or	or	CCONJ
dti-1336	21	9	inhibiting	inhibit	VERB
dti-1336	21	10	natural	natural	ADJ
dti-1336	21	11	anticoagulant	anticoagulant	ADJ
dti-1336	21	12	mechanisms	mechanism	NOUN
dti-1336	21	13	,	,	PUNCT
dti-1336	21	14	promote	promote	VERB
dti-1336	21	15	hypercoagulability	hypercoagulability	NOUN
dti-1336	21	16	.	.	PUNCT
dti-1336	22	1	deep	deep	ADJ
dti-1336	22	2	vein	vein	ADJ
dti-1336	22	3	thrombosis	thrombosis	NOUN
dti-1336	22	4	(	(	PUNCT
dti-1336	22	5	dvt	dvt	PROPN
dti-1336	22	6	)	)	PUNCT
dti-1336	22	7	or	or	CCONJ
dti-1336	22	8	pulmonary	pulmonary	ADJ
dti-1336	22	9	embolism	embolism	NOUN
dti-1336	22	10	are	be	AUX
dti-1336	22	11	the	the	DET
dti-1336	22	12	most	most	ADV
dti-1336	22	13	common	common	ADJ
dti-1336	22	14	manifestations	manifestation	NOUN
dti-1336	22	15	of	of	ADP
dti-1336	22	16	these	these	DET
dti-1336	22	17	disorders	disorder	NOUN
dti-1336	22	18	,	,	PUNCT
dti-1336	22	19	although	although	SCONJ
dti-1336	22	20	arterial	arterial	ADJ
dti-1336	22	21	thromboembolism	thromboembolism	NOUN
dti-1336	22	22	can	can	AUX
dti-1336	22	23	also	also	ADV
dti-1336	22	24	manifest	manifest	VERB
dti-1336	22	25	in	in	ADP
dti-1336	22	26	a	a	DET
dti-1336	22	27	minority	minority	NOUN
dti-1336	22	28	of	of	ADP
dti-1336	22	29	patients	patient	NOUN
dti-1336	22	30	.	.	PUNCT
dti-1336	23	1	the	the	DET
dti-1336	23	2	fi	fi	NOUN
dti-1336	23	3	rst	rst	PROPN
dti-1336	23	4	identifi	identifi	PROPN
dti-1336	23	5	ed	ed	NOUN
dti-1336	23	6	coagulation	coagulation	NOUN
dti-1336	23	7	defects	defect	NOUN
dti-1336	23	8	were	be	AUX
dti-1336	23	9	rare	rare	ADJ
dti-1336	23	10	but	but	CCONJ
dti-1336	23	11	strong	strong	ADJ
dti-1336	23	12	prothrombotic	prothrombotic	ADJ
dti-1336	23	13	factors	factor	NOUN
dti-1336	23	14	whereas	whereas	SCONJ
dti-1336	23	15	the	the	DET
dti-1336	23	16	more	more	ADV
dti-1336	23	17	recently	recently	ADV
dti-1336	23	18	described	describe	VERB
dti-1336	23	19	abnormalities	abnormality	NOUN
dti-1336	23	20	usually	usually	ADV
dti-1336	23	21	cause	cause	VERB
dti-1336	23	22	thrombosis	thrombosis	NOUN
dti-1336	23	23	only	only	ADV
dti-1336	23	24	in	in	ADP
dti-1336	23	25	the	the	DET
dti-1336	23	26	presence	presence	NOUN
dti-1336	23	27	of	of	ADP
dti-1336	23	28	additional	additional	ADJ
dti-1336	23	29	risk	risk	NOUN
dti-1336	23	30	factors	factor	NOUN
dti-1336	23	31	.	.	PUNCT
dti-1336	24	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1336	24	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1336	24	3	88	88	NUM
dti-1336	24	4	zangari	zangari	NOUN
dti-1336	24	5	et	et	PROPN
dti-1336	24	6	al	al	PROPN
dti-1336	24	7	drug	drug	PROPN
dti-1336	24	8	target	target	NOUN
dti-1336	24	9	insights	insight	NOUN
dti-1336	24	10	2008:3	2008:3	NUM
dti-1336	24	11	the	the	DET
dti-1336	24	12	family	family	NOUN
dti-1336	24	13	history	history	NOUN
dti-1336	24	14	of	of	ADP
dti-1336	24	15	the	the	DET
dti-1336	24	16	patient	patient	NOUN
dti-1336	24	17	is	be	AUX
dti-1336	24	18	itself	itself	PRON
dti-1336	24	19	an	an	DET
dti-1336	24	20	independent	independent	ADJ
dti-1336	24	21	thrombotic	thrombotic	ADJ
dti-1336	24	22	risk	risk	NOUN
dti-1336	24	23	factor	factor	NOUN
dti-1336	24	24	because	because	SCONJ
dti-1336	24	25	,	,	PUNCT
dti-1336	24	26	even	even	ADV
dti-1336	24	27	when	when	SCONJ
dti-1336	24	28	a	a	DET
dti-1336	24	29	specifi	specifi	PROPN
dti-1336	24	30	c	c	PROPN
dti-1336	24	31	defect	defect	NOUN
dti-1336	24	32	has	have	AUX
dti-1336	24	33	been	be	AUX
dti-1336	24	34	identifi	identifi	NOUN
dti-1336	24	35	ed	ed	NOUN
dti-1336	24	36	,	,	PUNCT
dti-1336	24	37	carriers	carrier	NOUN
dti-1336	24	38	of	of	ADP
dti-1336	24	39	thrombophilic	thrombophilic	ADJ
dti-1336	24	40	defects	defect	NOUN
dti-1336	24	41	that	that	PRON
dti-1336	24	42	belong	belong	VERB
dti-1336	24	43	to	to	ADP
dti-1336	24	44	a	a	DET
dti-1336	24	45	thrombophilic	thrombophilic	ADJ
dti-1336	24	46	family	family	NOUN
dti-1336	24	47	have	have	VERB
dti-1336	24	48	a	a	DET
dti-1336	24	49	worse	bad	ADJ
dti-1336	24	50	clinical	clinical	ADJ
dti-1336	24	51	course	course	NOUN
dti-1336	24	52	.	.	PUNCT
dti-1336	25	1	these	these	DET
dti-1336	25	2	patients	patient	NOUN
dti-1336	25	3	are	be	AUX
dti-1336	25	4	younger	young	ADJ
dti-1336	25	5	at	at	ADP
dti-1336	25	6	onset	onset	NOUN
dti-1336	25	7	and	and	CCONJ
dti-1336	25	8	have	have	VERB
dti-1336	25	9	a	a	DET
dti-1336	25	10	more	more	ADV
dti-1336	25	11	severe	severe	ADJ
dti-1336	25	12	phenotype	phenotype	NOUN
dti-1336	25	13	compared	compare	VERB
dti-1336	25	14	to	to	ADP
dti-1336	25	15	carriers	carrier	NOUN
dti-1336	25	16	of	of	ADP
dti-1336	25	17	the	the	DET
dti-1336	25	18	same	same	ADJ
dti-1336	25	19	defects	defect	NOUN
dti-1336	25	20	with	with	ADP
dti-1336	25	21	a	a	DET
dti-1336	25	22	silent	silent	ADJ
dti-1336	25	23	family	family	NOUN
dti-1336	26	1	history.2,3	history.2,3	ADJ
dti-1336	26	2	in	in	ADP
dti-1336	26	3	fact	fact	NOUN
dti-1336	26	4	,	,	PUNCT
dti-1336	26	5	thrombophilic	thrombophilic	ADJ
dti-1336	26	6	families	family	NOUN
dti-1336	26	7	harbor	harbor	VERB
dti-1336	26	8	synergistic	synergistic	ADJ
dti-1336	26	9	genetic	genetic	ADJ
dti-1336	26	10	defects	defect	NOUN
dti-1336	26	11	(	(	PUNCT
dti-1336	26	12	both	both	CCONJ
dti-1336	26	13	characterized	characterize	VERB
dti-1336	26	14	and	and	CCONJ
dti-1336	26	15	uncharacterized	uncharacterized	ADJ
dti-1336	26	16	)	)	PUNCT
dti-1336	26	17	that	that	PRON
dti-1336	26	18	contribute	contribute	VERB
dti-1336	26	19	to	to	ADP
dti-1336	26	20	the	the	DET
dti-1336	26	21	thrombotic	thrombotic	ADJ
dti-1336	26	22	risk	risk	NOUN
dti-1336	26	23	.	.	PUNCT
dti-1336	27	1	defi	defi	PROPN
dti-1336	27	2	ciencies	ciencie	NOUN
dti-1336	27	3	of	of	ADP
dti-1336	27	4	natural	natural	ADJ
dti-1336	27	5	anticoagulant	anticoagulant	ADJ
dti-1336	27	6	proteins	protein	NOUN
dti-1336	27	7	are	be	AUX
dti-1336	27	8	frequently	frequently	ADV
dti-1336	27	9	identifi	identifi	ADJ
dti-1336	27	10	ed	ed	NOUN
dti-1336	27	11	in	in	ADP
dti-1336	27	12	patients	patient	NOUN
dti-1336	27	13	with	with	ADP
dti-1336	27	14	thrombosis	thrombosis	NOUN
dti-1336	27	15	,	,	PUNCT
dti-1336	27	16	while	while	SCONJ
dti-1336	27	17	they	they	PRON
dti-1336	27	18	are	be	AUX
dti-1336	27	19	observed	observe	VERB
dti-1336	27	20	in	in	ADP
dti-1336	27	21	less	less	ADJ
dti-1336	27	22	than	than	ADP
dti-1336	27	23	1	1	NUM
dti-1336	27	24	%	%	NOUN
dti-1336	27	25	of	of	ADP
dti-1336	27	26	the	the	DET
dti-1336	27	27	general	general	ADJ
dti-1336	27	28	population	population	NOUN
dti-1336	27	29	.	.	PUNCT
dti-1336	28	1	figure	figure	NOUN
dti-1336	28	2	1	1	NUM
dti-1336	28	3	illustrates	illustrate	VERB
dti-1336	28	4	the	the	DET
dti-1336	28	5	inhibitory	inhibitory	ADJ
dti-1336	28	6	activity	activity	NOUN
dti-1336	28	7	of	of	ADP
dti-1336	28	8	the	the	DET
dti-1336	28	9	natural	natural	ADJ
dti-1336	28	10	anticoagulants	anticoagulant	NOUN
dti-1336	28	11	(	(	PUNCT
dti-1336	28	12	antithrombin	antithrombin	INTJ
dti-1336	28	13	,	,	PUNCT
dti-1336	28	14	the	the	DET
dti-1336	28	15	protein	protein	NOUN
dti-1336	28	16	c	c	NOUN
dti-1336	28	17	system	system	NOUN
dti-1336	28	18	)	)	PUNCT
dti-1336	28	19	on	on	ADP
dti-1336	28	20	the	the	DET
dti-1336	28	21	coagulation	coagulation	NOUN
dti-1336	28	22	cascade	cascade	NOUN
dti-1336	28	23	.	.	PUNCT
dti-1336	29	1	defi	defi	NOUN
dti-1336	29	2	ciency	ciency	NOUN
dti-1336	29	3	of	of	ADP
dti-1336	29	4	protein	protein	NOUN
dti-1336	29	5	c	c	NOUN
dti-1336	29	6	,	,	PUNCT
dti-1336	29	7	s	s	PART
dti-1336	29	8	or	or	CCONJ
dti-1336	29	9	antithrombin	antithrombin	NOUN
dti-1336	29	10	increases	increase	VERB
dti-1336	29	11	the	the	DET
dti-1336	29	12	risk	risk	NOUN
dti-1336	29	13	of	of	ADP
dti-1336	29	14	thrombosis	thrombosis	NOUN
dti-1336	29	15	approximately	approximately	ADV
dti-1336	29	16	10	10	NUM
dti-1336	29	17	-	-	NOUN
dti-1336	29	18	fold	fold	ADJ
dti-1336	29	19	in	in	ADP
dti-1336	29	20	heterozygotes	heterozygote	NOUN
dti-1336	29	21	,	,	PUNCT
dti-1336	29	22	while	while	SCONJ
dti-1336	29	23	homozygotes	homozygote	NOUN
dti-1336	29	24	may	may	AUX
dti-1336	29	25	develop	develop	VERB
dti-1336	29	26	purpura	purpura	NOUN
dti-1336	29	27	fulminans	fulminan	NOUN
dti-1336	29	28	(	(	PUNCT
dti-1336	29	29	with	with	ADP
dti-1336	29	30	laboratory	laboratory	NOUN
dti-1336	29	31	evidence	evidence	NOUN
dti-1336	29	32	of	of	ADP
dti-1336	29	33	dic	dic	NOUN
dti-1336	29	34	)	)	PUNCT
dti-1336	29	35	shortly	shortly	ADV
dti-1336	29	36	after	after	SCONJ
dti-1336	29	37	birth.4	birth.4	PROPN
dti-1336	29	38	levels	level	NOUN
dti-1336	29	39	of	of	ADP
dti-1336	29	40	natural	natural	ADJ
dti-1336	29	41	coagulation	coagulation	NOUN
dti-1336	29	42	inhibitors	inhibitor	NOUN
dti-1336	29	43	should	should	AUX
dti-1336	29	44	be	be	AUX
dti-1336	29	45	measured	measure	VERB
dti-1336	29	46	if	if	SCONJ
dti-1336	29	47	indicated	indicate	VERB
dti-1336	29	48	before	before	ADP
dti-1336	29	49	beginning	begin	VERB
dti-1336	29	50	anticoagulant	anticoagulant	NOUN
dti-1336	29	51	therapy	therapy	NOUN
dti-1336	29	52	or	or	CCONJ
dti-1336	29	53	after	after	ADP
dti-1336	29	54	its	its	PRON
dti-1336	29	55	discontinuation	discontinuation	NOUN
dti-1336	29	56	,	,	PUNCT
dti-1336	29	57	because	because	SCONJ
dti-1336	29	58	treatment	treatment	NOUN
dti-1336	29	59	affects	affect	VERB
dti-1336	29	60	the	the	DET
dti-1336	29	61	tests	test	NOUN
dti-1336	29	62	results	result	VERB
dti-1336	29	63	.	.	PUNCT
dti-1336	30	1	antithrombin	antithrombin	PROPN
dti-1336	30	2	defi	defi	PROPN
dti-1336	30	3	ciency	ciency	NOUN
dti-1336	30	4	this	this	PRON
dti-1336	30	5	a	a	DET
dti-1336	30	6	rare	rare	ADJ
dti-1336	30	7	defect	defect	NOUN
dti-1336	30	8	inherited	inherit	VERB
dti-1336	30	9	in	in	ADP
dti-1336	30	10	an	an	DET
dti-1336	30	11	autosomal	autosomal	ADJ
dti-1336	30	12	dominant	dominant	ADJ
dti-1336	30	13	fashion	fashion	NOUN
dti-1336	30	14	which	which	DET
dti-1336	30	15	prevalence	prevalence	NOUN
dti-1336	30	16	is	be	AUX
dti-1336	30	17	estimated	estimate	VERB
dti-1336	30	18	to	to	PART
dti-1336	30	19	be	be	AUX
dti-1336	30	20	one	one	NUM
dti-1336	30	21	in	in	ADP
dti-1336	30	22	1/2000	1/2000	NUM
dti-1336	30	23	to	to	ADP
dti-1336	30	24	1/5000	1/5000	NUM
dti-1336	30	25	persons.5	persons.5	PROPN
dti-1336	30	26	the	the	DET
dti-1336	30	27	prevalence	prevalence	NOUN
dti-1336	30	28	of	of	ADP
dti-1336	30	29	antithrombin	antithrombin	PROPN
dti-1336	30	30	defi	defi	PROPN
dti-1336	30	31	ciency	ciency	NOUN
dti-1336	30	32	in	in	ADP
dti-1336	30	33	patients	patient	NOUN
dti-1336	30	34	presenting	present	VERB
dti-1336	30	35	with	with	ADP
dti-1336	30	36	a	a	DET
dti-1336	30	37	fi	fi	NOUN
dti-1336	30	38	rst	rst	PROPN
dti-1336	30	39	thrombotic	thrombotic	ADJ
dti-1336	30	40	episode	episode	NOUN
dti-1336	30	41	is	be	AUX
dti-1336	30	42	1%.6	1%.6	NUM
dti-1336	30	43	antithrombin	antithrombin	ADJ
dti-1336	30	44	table	table	NOUN
dti-1336	30	45	1	1	NUM
dti-1336	30	46	.	.	PUNCT
dti-1336	30	47	hereditary	hereditary	ADJ
dti-1336	30	48	and	and	CCONJ
dti-1336	30	49	acquired	acquire	VERB
dti-1336	30	50	thrombophilia	thrombophilia	NOUN
dti-1336	30	51	.	.	PUNCT
dti-1336	31	1	for	for	ADP
dti-1336	31	2	the	the	DET
dti-1336	31	3	most	most	ADV
dti-1336	31	4	frequent	frequent	ADJ
dti-1336	31	5	conditions	condition	NOUN
dti-1336	31	6	,	,	PUNCT
dti-1336	31	7	the	the	DET
dti-1336	31	8	prevalence	prevalence	NOUN
dti-1336	31	9	in	in	ADP
dti-1336	31	10	patients	patient	NOUN
dti-1336	31	11	presenting	present	VERB
dti-1336	31	12	with	with	ADP
dti-1336	31	13	a	a	DET
dti-1336	31	14	fi	fi	NOUN
dti-1336	31	15	rst	rst	PROPN
dti-1336	31	16	episode	episode	NOUN
dti-1336	31	17	of	of	ADP
dti-1336	31	18	venous	venous	ADJ
dti-1336	31	19	thromboembolism	thromboembolism	NOUN
dti-1336	31	20	is	be	AUX
dti-1336	31	21	reported.1	reported.1	NOUN
dti-1336	31	22	hereditary	hereditary	ADJ
dti-1336	31	23	thrombophilia	thrombophilia	NOUN
dti-1336	31	24	prevalence	prevalence	NOUN
dti-1336	31	25	antithrombin	antithrombin	NOUN
dti-1336	31	26	defi	defi	PROPN
dti-1336	31	27	ciency	ciency	NOUN
dti-1336	31	28	1,1	1,1	NUM
dti-1336	31	29	%	%	NOUN
dti-1336	31	30	6	6	NUM
dti-1336	31	31	protein	protein	NOUN
dti-1336	31	32	c	c	PROPN
dti-1336	31	33	defi	defi	PROPN
dti-1336	31	34	ciency	ciency	NOUN
dti-1336	31	35	0,5–4	0,5–4	NOUN
dti-1336	31	36	%	%	NOUN
dti-1336	31	37	78	78	NUM
dti-1336	31	38	protein	protein	NOUN
dti-1336	31	39	s	s	PART
dti-1336	31	40	defi	defi	NOUN
dti-1336	31	41	ciency	ciency	NOUN
dti-1336	31	42	1,3	1,3	NUM
dti-1336	31	43	%	%	NOUN
dti-1336	31	44	80	80	NUM
dti-1336	31	45	factor	factor	NOUN
dti-1336	31	46	v	v	NOUN
dti-1336	31	47	leiden	leiden	PROPN
dti-1336	31	48	mutation	mutation	NOUN
dti-1336	31	49	12–40	12–40	NUM
dti-1336	31	50	%	%	NOUN
dti-1336	31	51	5,6	5,6	NUM
dti-1336	31	52	prothrombin	prothrombin	NOUN
dti-1336	31	53	gene	gene	NOUN
dti-1336	31	54	g20210a	g20210a	NOUN
dti-1336	31	55	mutation	mutation	NOUN
dti-1336	31	56	6–18	6–18	NOUN
dti-1336	31	57	%	%	NOUN
dti-1336	31	58	6	6	NUM
dti-1336	31	59	mthfr	mthfr	NOUN
dti-1336	31	60	mutation	mutation	NOUN
dti-1336	31	61	1,4–15	1,4–15	NUM
dti-1336	31	62	%	%	NOUN
dti-1336	31	63	79	79	NUM
dti-1336	31	64	factor	factor	NOUN
dti-1336	31	65	xii	xii	NOUN
dti-1336	31	66	defi	defi	NOUN
dti-1336	31	67	ciency	ciency	NOUN
dti-1336	31	68	2,3	2,3	NUM
dti-1336	31	69	%	%	NOUN
dti-1336	31	70	81,§	81,§	NOUN
dti-1336	31	71	dysfi	dysfi	PROPN
dti-1336	31	72	brinogenemias	brinogenemias	PROPN
dti-1336	31	73	,	,	PUNCT
dti-1336	31	74	plasminogen	plasminogen	NOUN
dti-1336	31	75	defi	defi	NOUN
dti-1336	31	76	ciency	ciency	NOUN
dti-1336	31	77	unknown	unknown	ADJ
dti-1336	31	78	acquired	acquire	VERB
dti-1336	31	79	thrombophilia	thrombophilia	NOUN
dti-1336	31	80	elderly	elderly	ADJ
dti-1336	31	81	trauma	trauma	NOUN
dti-1336	31	82	,	,	PUNCT
dti-1336	31	83	surgery	surgery	NOUN
dti-1336	31	84	,	,	PUNCT
dti-1336	31	85	especially	especially	ADV
dti-1336	31	86	orthopedic	orthopedic	ADJ
dti-1336	31	87	immobilization	immobilization	NOUN
dti-1336	31	88	,	,	PUNCT
dti-1336	31	89	long	long	ADJ
dti-1336	31	90	distance	distance	NOUN
dti-1336	31	91	travel	travel	NOUN
dti-1336	31	92	obesity	obesity	NOUN
dti-1336	31	93	pregnancy	pregnancy	NOUN
dti-1336	31	94	and	and	CCONJ
dti-1336	31	95	puerperium	puerperium	NOUN
dti-1336	31	96	oral	oral	ADJ
dti-1336	31	97	contraceptives	contraceptive	NOUN
dti-1336	31	98	and	and	CCONJ
dti-1336	31	99	hormone	hormone	NOUN
dti-1336	31	100	replacement	replacement	NOUN
dti-1336	31	101	therapy	therapy	NOUN
dti-1336	31	102	disseminated	disseminate	VERB
dti-1336	31	103	intravascular	intravascular	ADJ
dti-1336	31	104	coagulopathy	coagulopathy	ADJ
dti-1336	31	105	(	(	PUNCT
dti-1336	31	106	dic	dic	ADJ
dti-1336	31	107	)	)	PUNCT
dti-1336	31	108	malignancy	malignancy	NOUN
dti-1336	31	109	chemotherapy	chemotherapy	NOUN
dti-1336	31	110	,	,	PUNCT
dti-1336	31	111	tamoxifen	tamoxifen	NOUN
dti-1336	31	112	,	,	PUNCT
dti-1336	31	113	central	central	ADJ
dti-1336	31	114	venous	venous	ADJ
dti-1336	31	115	catheter	catheter	NOUN
dti-1336	31	116	heparin	heparin	NOUN
dti-1336	31	117	-	-	PUNCT
dti-1336	31	118	induced	induce	VERB
dti-1336	31	119	thrombocytopenia	thrombocytopenia	PROPN
dti-1336	31	120	nephrotic	nephrotic	ADJ
dti-1336	31	121	syndrome	syndrome	NOUN
dti-1336	31	122	,	,	PUNCT
dti-1336	31	123	congestive	congestive	ADJ
dti-1336	31	124	heart	heart	NOUN
dti-1336	31	125	failure	failure	NOUN
dti-1336	31	126	antiphospholipid	antiphospholipid	NOUN
dti-1336	31	127	antibody	antibody	NOUN
dti-1336	31	128	syndrome	syndrome	VERB
dti-1336	31	129	myeloproliferative	myeloproliferative	ADJ
dti-1336	31	130	disorders	disorder	NOUN
dti-1336	31	131	(	(	PUNCT
dti-1336	31	132	polcythemia	polcythemia	NOUN
dti-1336	31	133	vera	vera	NOUN
dti-1336	31	134	;	;	PUNCT
dti-1336	32	1	essential	essential	ADJ
dti-1336	32	2	thrombocythemia	thrombocythemia	NOUN
dti-1336	32	3	)	)	PUNCT
dti-1336	32	4	hyperviscosity	hyperviscosity	NOUN
dti-1336	32	5	(	(	PUNCT
dti-1336	32	6	waldenstrom	waldenstrom	NOUN
dti-1336	32	7	’s	’	VERB
dti-1336	32	8	macroglobulinemia	macroglobulinemia	ADJ
dti-1336	32	9	,	,	PUNCT
dti-1336	32	10	multiple	multiple	ADJ
dti-1336	32	11	myeloma	myeloma	NOUN
dti-1336	32	12	)	)	PUNCT
dti-1336	32	13	paroxysmal	paroxysmal	ADJ
dti-1336	32	14	nocturnal	nocturnal	ADJ
dti-1336	32	15	hemoglobinuria	hemoglobinuria	NOUN
dti-1336	32	16	,	,	PUNCT
dti-1336	32	17	sickle	sickle	NOUN
dti-1336	32	18	cell	cell	NOUN
dti-1336	32	19	anemia	anemia	NOUN
dti-1336	32	20	unknown	unknown	ADJ
dti-1336	32	21	or	or	CCONJ
dti-1336	32	22	mixed	mixed	ADJ
dti-1336	32	23	etiology	etiology	NOUN
dti-1336	32	24	hyperhomocystinemia	hyperhomocystinemia	NOUN
dti-1336	32	25	acquired	acquire	VERB
dti-1336	32	26	apc	apc	PROPN
dti-1336	32	27	(	(	PUNCT
dti-1336	32	28	activated	activate	VERB
dti-1336	32	29	protein	protein	NOUN
dti-1336	32	30	c	c	NOUN
dti-1336	32	31	)	)	PUNCT
dti-1336	32	32	resistance	resistance	NOUN
dti-1336	32	33	high	high	ADJ
dti-1336	32	34	levels	level	NOUN
dti-1336	32	35	of	of	ADP
dti-1336	32	36	factor	factor	NOUN
dti-1336	32	37	viii	viii	NOUN
dti-1336	32	38	,	,	PUNCT
dti-1336	32	39	factor	factor	NOUN
dti-1336	32	40	xi	xi	NOUN
dti-1336	32	41	,	,	PUNCT
dti-1336	32	42	factor	factor	NOUN
dti-1336	32	43	ix	ix	ADP
dti-1336	32	44	high	high	ADJ
dti-1336	32	45	levels	level	NOUN
dti-1336	32	46	of	of	ADP
dti-1336	32	47	tafi	tafi	PROPN
dti-1336	32	48	(	(	PUNCT
dti-1336	32	49	thrombin	thrombin	NOUN
dti-1336	32	50	-	-	PUNCT
dti-1336	32	51	activatable	activatable	ADJ
dti-1336	32	52	fi	fi	NOUN
dti-1336	32	53	brinolysis	brinolysis	NOUN
dti-1336	32	54	inhibitor	inhibitor	NOUN
dti-1336	32	55	)	)	PUNCT
dti-1336	32	56	low	low	ADJ
dti-1336	32	57	levels	level	NOUN
dti-1336	32	58	of	of	ADP
dti-1336	32	59	free	free	ADJ
dti-1336	32	60	tfpi	tfpi	ADJ
dti-1336	32	61	(	(	PUNCT
dti-1336	32	62	tissue	tissue	NOUN
dti-1336	32	63	factor	factor	NOUN
dti-1336	32	64	pathway	pathway	NOUN
dti-1336	32	65	inhibitor	inhibitor	NOUN
dti-1336	32	66	)	)	PUNCT
dti-1336	32	67	§	§	NOUN
dti-1336	32	68	prevalenve	prevalenve	NOUN
dti-1336	32	69	in	in	ADP
dti-1336	32	70	the	the	DET
dti-1336	32	71	general	general	ADJ
dti-1336	32	72	population	population	NOUN
dti-1336	32	73	.	.	PUNCT
dti-1336	33	1	89	89	NUM
dti-1336	33	2	thrombophilia	thrombophilia	PROPN
dti-1336	33	3	drug	drug	NOUN
dti-1336	33	4	target	target	NOUN
dti-1336	33	5	insights	insight	NOUN
dti-1336	33	6	2008:3	2008:3	NUM
dti-1336	33	7	(	(	PUNCT
dti-1336	33	8	or	or	CCONJ
dti-1336	33	9	antithrombin	antithrombin	PROPN
dti-1336	33	10	iii	iii	PROPN
dti-1336	33	11	)	)	PUNCT
dti-1336	33	12	is	be	AUX
dti-1336	33	13	a	a	DET
dti-1336	33	14	plasma	plasma	NOUN
dti-1336	33	15	anti	anti	ADJ
dti-1336	33	16	protease	protease	NOUN
dti-1336	33	17	that	that	PRON
dti-1336	33	18	belong	belong	VERB
dti-1336	33	19	to	to	ADP
dti-1336	33	20	the	the	DET
dti-1336	33	21	serpin	serpin	PROPN
dti-1336	33	22	group	group	PROPN
dti-1336	33	23	inhibits	inhibit	VERB
dti-1336	33	24	thrombin	thrombin	NOUN
dti-1336	33	25	by	by	ADP
dti-1336	33	26	irreversibly	irreversibly	ADV
dti-1336	33	27	binding	bind	VERB
dti-1336	33	28	in	in	ADP
dti-1336	33	29	a	a	DET
dti-1336	33	30	1:1	1:1	NUM
dti-1336	33	31	complex	complex	NOUN
dti-1336	33	32	.	.	PUNCT
dti-1336	34	1	type	type	NOUN
dti-1336	34	2	i	i	PRON
dti-1336	34	3	defi	defi	VERB
dti-1336	34	4	ciency	ciency	NOUN
dti-1336	34	5	is	be	AUX
dti-1336	34	6	characterized	characterize	VERB
dti-1336	34	7	by	by	ADP
dti-1336	34	8	low	low	ADJ
dti-1336	34	9	antithrombin	antithrombin	ADJ
dti-1336	34	10	antigen	antigen	PROPN
dti-1336	34	11	levels	level	NOUN
dti-1336	34	12	,	,	PUNCT
dti-1336	34	13	whereas	whereas	SCONJ
dti-1336	34	14	in	in	ADP
dti-1336	34	15	type	type	NOUN
dti-1336	34	16	ii	ii	PROPN
dti-1336	34	17	is	be	AUX
dti-1336	34	18	caused	cause	VERB
dti-1336	34	19	by	by	ADP
dti-1336	34	20	a	a	DET
dti-1336	34	21	mutation	mutation	NOUN
dti-1336	34	22	in	in	ADP
dti-1336	34	23	the	the	DET
dti-1336	34	24	thrombin	thrombin	NOUN
dti-1336	34	25	binding	bind	VERB
dti-1336	34	26	site	site	NOUN
dti-1336	34	27	producing	produce	VERB
dti-1336	34	28	a	a	DET
dti-1336	34	29	dysfunctional	dysfunctional	ADJ
dti-1336	34	30	molecule	molecule	NOUN
dti-1336	34	31	,	,	PUNCT
dti-1336	34	32	with	with	ADP
dti-1336	34	33	normal	normal	ADJ
dti-1336	34	34	antigen	antigen	ADJ
dti-1336	34	35	level	level	NOUN
dti-1336	34	36	and	and	CCONJ
dti-1336	34	37	reduced	reduce	VERB
dti-1336	34	38	antithrombin	antithrombin	NOUN
dti-1336	34	39	activity.7	activity.7	PROPN
dti-1336	35	1	there	there	PRON
dti-1336	35	2	are	be	VERB
dti-1336	35	3	no	no	DET
dti-1336	35	4	clinical	clinical	ADJ
dti-1336	35	5	differences	difference	NOUN
dti-1336	35	6	between	between	ADP
dti-1336	35	7	the	the	DET
dti-1336	35	8	two	two	NUM
dti-1336	35	9	types	type	NOUN
dti-1336	35	10	.	.	PUNCT
dti-1336	36	1	the	the	DET
dti-1336	36	2	best	good	ADJ
dti-1336	36	3	single	single	ADJ
dti-1336	36	4	screening	screening	NOUN
dti-1336	36	5	test	test	NOUN
dti-1336	36	6	for	for	ADP
dti-1336	36	7	this	this	DET
dti-1336	36	8	disorder	disorder	NOUN
dti-1336	36	9	is	be	AUX
dti-1336	36	10	the	the	DET
dti-1336	36	11	antithrombin	antithrombin	NOUN
dti-1336	36	12	-	-	PUNCT
dti-1336	36	13	heparin	heparin	ADJ
dti-1336	36	14	cofactor	cofactor	NOUN
dti-1336	36	15	assay	assay	VERB
dti-1336	36	16	that	that	SCONJ
dti-1336	36	17	measures	measure	NOUN
dti-1336	36	18	factor	factor	NOUN
dti-1336	36	19	xa	xa	NOUN
dti-1336	36	20	inhibition	inhibition	NOUN
dti-1336	36	21	.	.	PUNCT
dti-1336	37	1	heterozygotes	heterozygote	NOUN
dti-1336	37	2	have	have	VERB
dti-1336	37	3	8.1	8.1	NUM
dti-1336	37	4	times	time	NOUN
dti-1336	37	5	higher	high	ADJ
dti-1336	37	6	probability	probability	NOUN
dti-1336	37	7	of	of	ADP
dti-1336	37	8	developing	develop	VERB
dti-1336	37	9	thrombosis.8	thrombosis.8	ADP
dti-1336	37	10	recurrent	recurrent	ADJ
dti-1336	37	11	thrombotic	thrombotic	ADJ
dti-1336	37	12	episodes	episode	NOUN
dti-1336	37	13	occur	occur	VERB
dti-1336	37	14	in	in	ADP
dti-1336	37	15	60	60	NUM
dti-1336	37	16	%	%	NOUN
dti-1336	37	17	of	of	ADP
dti-1336	37	18	patients9	patients9	NOUN
dti-1336	37	19	and	and	CCONJ
dti-1336	37	20	40	40	NUM
dti-1336	37	21	%	%	NOUN
dti-1336	37	22	exhibit	exhibit	NOUN
dti-1336	37	23	pulmonary	pulmonary	ADJ
dti-1336	37	24	embolism.10	embolism.10	NOUN
dti-1336	37	25	patients	patient	NOUN
dti-1336	37	26	with	with	ADP
dti-1336	37	27	an	an	DET
dti-1336	37	28	acute	acute	ADJ
dti-1336	37	29	thrombotic	thrombotic	ADJ
dti-1336	37	30	episode	episode	NOUN
dti-1336	37	31	should	should	AUX
dti-1336	37	32	be	be	AUX
dti-1336	37	33	treated	treat	VERB
dti-1336	37	34	with	with	ADP
dti-1336	37	35	heparin	heparin	NOUN
dti-1336	37	36	,	,	PUNCT
dti-1336	37	37	although	although	SCONJ
dti-1336	37	38	in	in	ADP
dti-1336	37	39	some	some	DET
dti-1336	37	40	patients	patient	NOUN
dti-1336	37	41	antithrombin	antithrombin	PROPN
dti-1336	37	42	iii	iii	PROPN
dti-1336	37	43	replacement	replacement	NOUN
dti-1336	37	44	may	may	AUX
dti-1336	37	45	be	be	AUX
dti-1336	37	46	useful.11	useful.11	ADJ
dti-1336	37	47	f	f	PROPN
dti-1336	37	48	va	va	PROPN
dti-1336	37	49	f	f	PROPN
dti-1336	37	50	viiia	viiia	PROPN
dti-1336	37	51	f	f	PROPN
dti-1336	37	52	xf	xf	PROPN
dti-1336	37	53	xa	xa	PROPN
dti-1336	37	54	f	f	PROPN
dti-1336	37	55	xa	xa	PROPN
dti-1336	37	56	tissue	tissue	NOUN
dti-1336	37	57	factor	factor	NOUN
dti-1336	37	58	factor	factor	NOUN
dti-1336	37	59	viia	viia	PROPN
dti-1336	37	60	t	t	PROPN
dti-1336	37	61	prothrombin	prothrombin	NOUN
dti-1336	37	62	fibrinogen	fibrinogen	NOUN
dti-1336	37	63	fibrin	fibrin	NOUN
dti-1336	37	64	thrombomodulin	thrombomodulin	PROPN
dti-1336	37	65	t	t	PROPN
dti-1336	37	66	pc	pc	NOUN
dti-1336	37	67	s	s	NOUN
dti-1336	37	68	c4bp	c4bp	X
dti-1336	37	69	apc	apc	PROPN
dti-1336	37	70	tm	tm	PROPN
dti-1336	37	71	t	t	PROPN
dti-1336	37	72	s	s	PROPN
dti-1336	37	73	apc	apc	PROPN
dti-1336	37	74	f	f	PROPN
dti-1336	37	75	ixa	ixa	PROPN
dti-1336	37	76	thrombin	thrombin	NOUN
dti-1336	37	77	protein	protein	NOUN
dti-1336	37	78	s	s	PART
dti-1336	37	79	protein	protein	NOUN
dti-1336	37	80	c	c	PROPN
dti-1336	37	81	antithrombin	antithrombin	PROPN
dti-1336	37	82	intrinsic	intrinsic	ADJ
dti-1336	37	83	pathway	pathway	PROPN
dti-1336	37	84	heparan	heparan	NOUN
dti-1336	37	85	sulfa	sulfa	NOUN
dti-1336	38	1	te	te	PROPN
dti-1336	38	2	f	f	PROPN
dti-1336	38	3	va	va	PROPN
dti-1336	38	4	f	f	PROPN
dti-1336	38	5	viiia	viiia	PROPN
dti-1336	38	6	t	t	PROPN
dti-1336	38	7	prothrombin	prothrombin	NOUN
dti-1336	38	8	fibrinogen	fibrinogen	NOUN
dti-1336	38	9	fibrin	fibrin	NOUN
dti-1336	38	10	t	t	PROPN
dti-1336	38	11	pc	pc	NOUN
dti-1336	38	12	s	s	VERB
dti-1336	38	13	apc	apc	PROPN
dti-1336	38	14	t	t	PROPN
dti-1336	38	15	s	s	PROPN
dti-1336	39	1	apc	apc	PROPN
dti-1336	39	2	thrombin	thrombin	PROPN
dti-1336	39	3	antithrombin	antithrombin	PROPN
dti-1336	39	4	f	f	PROPN
dti-1336	40	1	vaf	vaf	PROPN
dti-1336	40	2	va	va	PROPN
dti-1336	40	3	f	f	PROPN
dti-1336	40	4	viiiaf	viiiaf	NOUN
dti-1336	40	5	viiia	viiia	ADP
dti-1336	40	6	tt	tt	PROPN
dti-1336	40	7	prothrombinprothrombin	prothrombinprothrombin	PROPN
dti-1336	40	8	tt	tt	PROPN
dti-1336	40	9	pcpcpc	pcpcpc	PROPN
dti-1336	40	10	ss	ss	PROPN
dti-1336	40	11	apcapc	apcapc	NOUN
dti-1336	41	1	tt	tt	PROPN
dti-1336	41	2	s	s	PROPN
dti-1336	41	3	apc	apc	PROPN
dti-1336	41	4	ss	ss	PROPN
dti-1336	41	5	apcapc	apcapc	PROPN
dti-1336	41	6	antithrombin	antithrombin	PROPN
dti-1336	41	7	figure	figure	NOUN
dti-1336	41	8	1	1	NUM
dti-1336	41	9	.	.	PUNCT
dti-1336	41	10	inhibitory	inhibitory	ADJ
dti-1336	41	11	effect	effect	NOUN
dti-1336	41	12	of	of	ADP
dti-1336	41	13	natural	natural	ADJ
dti-1336	41	14	anticoagulants	anticoagulant	NOUN
dti-1336	41	15	on	on	ADP
dti-1336	41	16	the	the	DET
dti-1336	41	17	coagulation	coagulation	NOUN
dti-1336	41	18	cascade	cascade	NOUN
dti-1336	41	19	.	.	PUNCT
dti-1336	42	1	thrombin	thrombin	NOUN
dti-1336	42	2	(	(	PUNCT
dti-1336	42	3	t	t	PROPN
dti-1336	42	4	)	)	PUNCT
dti-1336	42	5	,	,	PUNCT
dti-1336	42	6	beside	beside	ADP
dti-1336	42	7	its	its	PRON
dti-1336	42	8	procoagulant	procoagulant	ADJ
dti-1336	42	9	enzymatic	enzymatic	ADJ
dti-1336	42	10	activity	activity	NOUN
dti-1336	42	11	of	of	ADP
dti-1336	42	12	fi	fi	NOUN
dti-1336	42	13	brinogen	brinogen	NOUN
dti-1336	42	14	activation	activation	NOUN
dti-1336	42	15	,	,	PUNCT
dti-1336	42	16	is	be	AUX
dti-1336	42	17	able	able	ADJ
dti-1336	42	18	to	to	PART
dti-1336	42	19	bind	bind	VERB
dti-1336	42	20	thrombomodulin	thrombomodulin	PROPN
dti-1336	42	21	(	(	PUNCT
dti-1336	42	22	tm	tm	PROPN
dti-1336	42	23	)	)	PUNCT
dti-1336	42	24	and	and	CCONJ
dti-1336	42	25	activate	activate	VERB
dti-1336	42	26	protein	protein	NOUN
dti-1336	42	27	c	c	NOUN
dti-1336	42	28	to	to	ADP
dti-1336	42	29	activated	activate	VERB
dti-1336	42	30	protein	protein	NOUN
dti-1336	42	31	c	c	NOUN
dti-1336	42	32	(	(	PUNCT
dti-1336	42	33	apc	apc	PROPN
dti-1336	42	34	)	)	PUNCT
dti-1336	42	35	.	.	PUNCT
dti-1336	43	1	apc	apc	PROPN
dti-1336	43	2	binds	bind	VERB
dti-1336	43	3	free	free	ADJ
dti-1336	43	4	protein	protein	NOUN
dti-1336	43	5	s	s	PART
dti-1336	43	6	(	(	PUNCT
dti-1336	43	7	s	s	NOUN
dti-1336	43	8	)	)	PUNCT
dti-1336	43	9	,	,	PUNCT
dti-1336	43	10	which	which	PRON
dti-1336	43	11	acts	act	VERB
dti-1336	43	12	as	as	ADP
dti-1336	43	13	a	a	DET
dti-1336	43	14	cofactor	cofactor	NOUN
dti-1336	43	15	by	by	ADP
dti-1336	43	16	enhancing	enhance	VERB
dti-1336	43	17	the	the	DET
dti-1336	43	18	activity	activity	NOUN
dti-1336	43	19	of	of	ADP
dti-1336	43	20	apc	apc	PROPN
dti-1336	43	21	.	.	PUNCT
dti-1336	44	1	the	the	DET
dti-1336	44	2	complex	complex	NOUN
dti-1336	44	3	can	can	AUX
dti-1336	44	4	inhibit	inhibit	VERB
dti-1336	44	5	the	the	DET
dti-1336	44	6	coagulation	coagulation	NOUN
dti-1336	44	7	cascade	cascade	NOUN
dti-1336	44	8	by	by	ADP
dti-1336	44	9	the	the	DET
dti-1336	44	10	inactivation	inactivation	NOUN
dti-1336	44	11	of	of	ADP
dti-1336	44	12	factor	factor	NOUN
dti-1336	44	13	va	va	NOUN
dti-1336	44	14	and	and	CCONJ
dti-1336	44	15	factor	factor	NOUN
dti-1336	44	16	viiia	viiia	NOUN
dti-1336	44	17	.	.	PUNCT
dti-1336	45	1	antithrombin	antithrombin	PROPN
dti-1336	45	2	associated	associate	VERB
dti-1336	45	3	with	with	ADP
dti-1336	45	4	heparan	heparan	ADJ
dti-1336	45	5	sulfate	sulfate	NOUN
dti-1336	45	6	molecules	molecule	NOUN
dti-1336	45	7	on	on	ADP
dti-1336	45	8	the	the	DET
dti-1336	45	9	surface	surface	NOUN
dti-1336	45	10	of	of	ADP
dti-1336	45	11	vascular	vascular	ADJ
dti-1336	45	12	endothelium	endothelium	NOUN
dti-1336	45	13	inactivates	inactivate	VERB
dti-1336	45	14	thrombin	thrombin	NOUN
dti-1336	45	15	and	and	CCONJ
dti-1336	45	16	factor	factor	NOUN
dti-1336	45	17	xa	xa	PROPN
dti-1336	45	18	.	.	PUNCT
dti-1336	45	19	abbreviations	abbreviation	NOUN
dti-1336	45	20	:	:	PUNCT
dti-1336	45	21	c4bp	c4bp	X
dti-1336	45	22	:	:	PUNCT
dti-1336	45	23	c4b	c4b	ADJ
dti-1336	45	24	binding	bind	VERB
dti-1336	45	25	protein	protein	NOUN
dti-1336	45	26	;	;	PUNCT
dti-1336	45	27	pc	pc	NOUN
dti-1336	45	28	:	:	PUNCT
dti-1336	45	29	protein	protein	NOUN
dti-1336	45	30	c	c	NOUN
dti-1336	45	31	;	;	PUNCT
dti-1336	45	32	apc	apc	PROPN
dti-1336	45	33	:	:	PUNCT
dti-1336	45	34	activated	activate	VERB
dti-1336	45	35	protein	protein	NOUN
dti-1336	45	36	c	c	NOUN
dti-1336	45	37	;	;	PUNCT
dti-1336	45	38	tm	tm	NOUN
dti-1336	45	39	:	:	PUNCT
dti-1336	45	40	thrombomodulin	thrombomodulin	PROPN
dti-1336	45	41	;	;	PUNCT
dti-1336	45	42	s	s	X
dti-1336	45	43	:	:	PUNCT
dti-1336	45	44	protein	protein	NOUN
dti-1336	45	45	s	s	PROPN
dti-1336	45	46	;	;	PUNCT
dti-1336	45	47	t	t	PROPN
dti-1336	45	48	:	:	PUNCT
dti-1336	45	49	thrombin	thrombin	NOUN
dti-1336	45	50	.	.	PUNCT
dti-1336	46	1	90	90	NUM
dti-1336	46	2	zangari	zangari	PROPN
dti-1336	46	3	et	et	PROPN
dti-1336	46	4	al	al	PROPN
dti-1336	46	5	drug	drug	PROPN
dti-1336	46	6	target	target	NOUN
dti-1336	46	7	insights	insight	NOUN
dti-1336	46	8	2008:3	2008:3	NUM
dti-1336	46	9	protein	protein	NOUN
dti-1336	46	10	c	c	NOUN
dti-1336	46	11	and	and	CCONJ
dti-1336	46	12	protein	protein	NOUN
dti-1336	46	13	s	s	PART
dti-1336	46	14	defi	defi	NOUN
dti-1336	46	15	ciencies	ciencie	NOUN
dti-1336	46	16	protein	protein	NOUN
dti-1336	46	17	c	c	PROPN
dti-1336	46	18	defi	defi	NOUN
dti-1336	46	19	ciency	ciency	NOUN
dti-1336	46	20	is	be	AUX
dti-1336	46	21	a	a	DET
dti-1336	46	22	common	common	ADJ
dti-1336	46	23	defect	defect	NOUN
dti-1336	46	24	in	in	ADP
dti-1336	46	25	the	the	DET
dti-1336	46	26	general	general	ADJ
dti-1336	46	27	caucasian	caucasian	ADJ
dti-1336	46	28	population	population	NOUN
dti-1336	46	29	,	,	PUNCT
dti-1336	46	30	where	where	SCONJ
dti-1336	46	31	the	the	DET
dti-1336	46	32	prevalence	prevalence	NOUN
dti-1336	46	33	of	of	ADP
dti-1336	46	34	heterozygous	heterozygous	ADJ
dti-1336	46	35	protein	protein	NOUN
dti-1336	46	36	c	c	NOUN
dti-1336	46	37	defi	defi	VERB
dti-1336	46	38	ciency	ciency	NOUN
dti-1336	46	39	in	in	ADP
dti-1336	46	40	non	non	ADJ
dti-1336	46	41	symptomatic	symptomatic	ADJ
dti-1336	46	42	subjects	subject	NOUN
dti-1336	46	43	ranges	range	VERB
dti-1336	46	44	from	from	ADP
dti-1336	46	45	1/200	1/200	NUM
dti-1336	46	46	to	to	ADP
dti-1336	46	47	1/500	1/500	NUM
dti-1336	46	48	and	and	CCONJ
dti-1336	46	49	1/3000–1/5000	1/3000–1/5000	NUM
dti-1336	46	50	in	in	ADP
dti-1336	46	51	symptomatic	symptomatic	ADJ
dti-1336	46	52	patients	patient	NOUN
dti-1336	46	53	.	.	PUNCT
dti-1336	47	1	heterozygous	heterozygous	ADJ
dti-1336	47	2	protein	protein	NOUN
dti-1336	47	3	c	c	PROPN
dti-1336	47	4	defi	defi	NOUN
dti-1336	47	5	ciency	ciency	NOUN
dti-1336	47	6	can	can	AUX
dti-1336	47	7	be	be	AUX
dti-1336	47	8	inherited	inherit	VERB
dti-1336	47	9	in	in	ADP
dti-1336	47	10	an	an	DET
dti-1336	47	11	autosomal	autosomal	ADJ
dti-1336	47	12	dominant	dominant	ADJ
dti-1336	47	13	fashion	fashion	NOUN
dti-1336	47	14	or	or	CCONJ
dti-1336	47	15	in	in	ADP
dti-1336	47	16	a	a	DET
dti-1336	47	17	more	more	ADV
dti-1336	47	18	severe	severe	ADJ
dti-1336	47	19	autosomal	autosomal	ADJ
dti-1336	47	20	recessive	recessive	ADJ
dti-1336	47	21	manner.5	manner.5	PROPN
dti-1336	47	22	type	type	NOUN
dti-1336	47	23	i	i	PRON
dti-1336	47	24	(	(	PUNCT
dti-1336	47	25	reduced	reduce	VERB
dti-1336	47	26	enzymatic	enzymatic	ADJ
dti-1336	47	27	and	and	CCONJ
dti-1336	47	28	immunological	immunological	ADJ
dti-1336	47	29	activity	activity	NOUN
dti-1336	47	30	)	)	PUNCT
dti-1336	47	31	and	and	CCONJ
dti-1336	47	32	type	type	PROPN
dti-1336	47	33	ii	ii	PROPN
dti-1336	47	34	(	(	PUNCT
dti-1336	47	35	dysfunctional	dysfunctional	ADJ
dti-1336	47	36	protein	protein	NOUN
dti-1336	47	37	c	c	NOUN
dti-1336	47	38	)	)	PUNCT
dti-1336	47	39	defi	defi	PROPN
dti-1336	47	40	ciencies	ciencie	NOUN
dti-1336	47	41	have	have	AUX
dti-1336	47	42	been	be	AUX
dti-1336	47	43	described.12	described.12	VERB
dti-1336	47	44	heterozygous	heterozygous	ADJ
dti-1336	47	45	protein	protein	NOUN
dti-1336	47	46	c	c	NOUN
dti-1336	47	47	defi	defi	NOUN
dti-1336	47	48	ciency	ciency	NOUN
dti-1336	47	49	produces	produce	VERB
dti-1336	47	50	a	a	DET
dti-1336	47	51	7.3	7.3	NUM
dti-1336	47	52	fold	fold	NOUN
dti-1336	47	53	increase	increase	NOUN
dti-1336	47	54	risk	risk	NOUN
dti-1336	47	55	of	of	ADP
dti-1336	47	56	thrombosis.8	thrombosis.8	PROPN
dti-1336	47	57	warfarin	warfarin	NOUN
dti-1336	47	58	-	-	PUNCT
dti-1336	47	59	induced	induce	VERB
dti-1336	47	60	skin	skin	NOUN
dti-1336	47	61	necrosis	necrosis	NOUN
dti-1336	47	62	has	have	AUX
dti-1336	47	63	been	be	AUX
dti-1336	47	64	associated	associate	VERB
dti-1336	47	65	with	with	ADP
dti-1336	47	66	this	this	DET
dti-1336	47	67	disorder	disorder	NOUN
dti-1336	47	68	,	,	PUNCT
dti-1336	47	69	but	but	CCONJ
dti-1336	47	70	it	it	PRON
dti-1336	47	71	is	be	AUX
dti-1336	47	72	not	not	PART
dti-1336	47	73	specifi	specifi	PROPN
dti-1336	47	74	c	c	PROPN
dti-1336	47	75	for	for	ADP
dti-1336	47	76	this	this	DET
dti-1336	47	77	condition	condition	NOUN
dti-1336	47	78	.	.	PUNCT
dti-1336	48	1	this	this	DET
dti-1336	48	2	syndrome	syndrome	NOUN
dti-1336	48	3	develops	develop	VERB
dti-1336	48	4	in	in	ADP
dti-1336	48	5	the	the	DET
dti-1336	48	6	fi	fi	NOUN
dti-1336	48	7	rst	rst	NOUN
dti-1336	48	8	few	few	ADJ
dti-1336	48	9	days	day	NOUN
dti-1336	48	10	of	of	ADP
dti-1336	48	11	warfarin	warfarin	NOUN
dti-1336	48	12	treatment	treatment	NOUN
dti-1336	48	13	,	,	PUNCT
dti-1336	48	14	when	when	SCONJ
dti-1336	48	15	protein	protein	NOUN
dti-1336	48	16	c	c	NOUN
dti-1336	48	17	levels	level	NOUN
dti-1336	48	18	can	can	AUX
dti-1336	48	19	decrease	decrease	VERB
dti-1336	48	20	to	to	ADP
dti-1336	48	21	50	50	NUM
dti-1336	48	22	%	%	NOUN
dti-1336	48	23	of	of	ADP
dti-1336	48	24	normal	normal	ADJ
dti-1336	48	25	level	level	NOUN
dti-1336	48	26	,	,	PUNCT
dti-1336	48	27	causing	cause	VERB
dti-1336	48	28	an	an	DET
dti-1336	48	29	active	active	ADJ
dti-1336	48	30	prothrombotic	prothrombotic	NOUN
dti-1336	48	31	state.13	state.13	NOUN
dti-1336	48	32	rare	rare	ADJ
dti-1336	48	33	cases	case	NOUN
dti-1336	48	34	of	of	ADP
dti-1336	48	35	purpura	purpura	NOUN
dti-1336	48	36	fulminans	fulminan	NOUN
dti-1336	48	37	have	have	AUX
dti-1336	48	38	been	be	AUX
dti-1336	48	39	described	describe	VERB
dti-1336	48	40	in	in	ADP
dti-1336	48	41	newborns	newborn	NOUN
dti-1336	48	42	with	with	ADP
dti-1336	48	43	less	less	ADJ
dti-1336	48	44	than	than	ADP
dti-1336	48	45	1	1	NUM
dti-1336	48	46	%	%	NOUN
dti-1336	48	47	protein	protein	NOUN
dti-1336	48	48	c	c	NOUN
dti-1336	48	49	activity	activity	NOUN
dti-1336	48	50	,	,	PUNCT
dti-1336	48	51	which	which	PRON
dti-1336	48	52	resulted	result	VERB
dti-1336	48	53	from	from	ADP
dti-1336	48	54	homozygous	homozygous	ADJ
dti-1336	48	55	or	or	CCONJ
dti-1336	48	56	double	double	ADJ
dti-1336	48	57	heterozygous	heterozygous	ADJ
dti-1336	48	58	mutations	mutation	NOUN
dti-1336	48	59	for	for	ADP
dti-1336	48	60	protein	protein	NOUN
dti-1336	48	61	c	c	PROPN
dti-1336	48	62	defi	defi	PROPN
dti-1336	48	63	ciency.14	ciency.14	PROPN
dti-1336	48	64	in	in	ADP
dti-1336	48	65	order	order	NOUN
dti-1336	48	66	to	to	PART
dti-1336	48	67	avoid	avoid	VERB
dti-1336	48	68	skin	skin	NOUN
dti-1336	48	69	necrosis	necrosis	NOUN
dti-1336	48	70	in	in	ADP
dti-1336	48	71	patients	patient	NOUN
dti-1336	48	72	with	with	ADP
dti-1336	48	73	known	know	VERB
dti-1336	48	74	protein	protein	NOUN
dti-1336	48	75	c	c	PROPN
dti-1336	48	76	defi	defi	NOUN
dti-1336	48	77	ciency	ciency	NOUN
dti-1336	48	78	warfarin	warfarin	NOUN
dti-1336	48	79	treatment	treatment	NOUN
dti-1336	48	80	should	should	AUX
dti-1336	48	81	start	start	VERB
dti-1336	48	82	at	at	ADP
dti-1336	48	83	a	a	DET
dti-1336	48	84	low	low	ADJ
dti-1336	48	85	dose	dose	NOUN
dti-1336	48	86	and	and	CCONJ
dti-1336	48	87	only	only	ADV
dti-1336	48	88	after	after	ADP
dti-1336	48	89	full	full	ADJ
dti-1336	48	90	heparinization	heparinization	NOUN
dti-1336	48	91	.	.	PUNCT
dti-1336	49	1	in	in	ADP
dti-1336	49	2	patients	patient	NOUN
dti-1336	49	3	with	with	ADP
dti-1336	49	4	a	a	DET
dti-1336	49	5	previous	previous	ADJ
dti-1336	49	6	episode	episode	NOUN
dti-1336	49	7	of	of	ADP
dti-1336	49	8	skin	skin	NOUN
dti-1336	49	9	necrosis	necrosis	NOUN
dti-1336	49	10	,	,	PUNCT
dti-1336	49	11	administration	administration	NOUN
dti-1336	49	12	of	of	ADP
dti-1336	49	13	protein	protein	NOUN
dti-1336	49	14	c	c	PROPN
dti-1336	49	15	concentrates	concentrate	VERB
dti-1336	49	16	(	(	PUNCT
dti-1336	49	17	or	or	CCONJ
dti-1336	49	18	alternatively	alternatively	ADV
dti-1336	49	19	fresh	fresh	ADJ
dti-1336	49	20	frozen	frozen	ADJ
dti-1336	49	21	plasma	plasma	NOUN
dti-1336	49	22	)	)	PUNCT
dti-1336	49	23	can	can	AUX
dti-1336	49	24	be	be	AUX
dti-1336	49	25	protective	protective	ADJ
dti-1336	49	26	at	at	ADP
dti-1336	49	27	the	the	DET
dti-1336	49	28	beginning	beginning	NOUN
dti-1336	49	29	of	of	ADP
dti-1336	49	30	oral	oral	ADJ
dti-1336	49	31	anticoagulant	anticoagulant	NOUN
dti-1336	49	32	therapy	therapy	NOUN
dti-1336	49	33	.	.	PUNCT
dti-1336	50	1	protein	protein	NOUN
dti-1336	50	2	c	c	PROPN
dti-1336	50	3	defi	defi	PROPN
dti-1336	50	4	ciency	ciency	NOUN
dti-1336	50	5	can	can	AUX
dti-1336	50	6	be	be	AUX
dti-1336	50	7	acquired	acquire	VERB
dti-1336	50	8	in	in	ADP
dti-1336	50	9	conditions	condition	NOUN
dti-1336	50	10	like	like	ADP
dti-1336	50	11	liver	liver	NOUN
dti-1336	50	12	diseases	disease	NOUN
dti-1336	50	13	,	,	PUNCT
dti-1336	50	14	dic	dic	ADJ
dti-1336	50	15	,	,	PUNCT
dti-1336	50	16	sepsis	sepsis	NOUN
dti-1336	50	17	,	,	PUNCT
dti-1336	50	18	and	and	CCONJ
dti-1336	50	19	in	in	ADP
dti-1336	50	20	malignancies	malignancy	NOUN
dti-1336	50	21	treated	treat	VERB
dti-1336	50	22	with	with	ADP
dti-1336	50	23	l	l	NOUN
dti-1336	50	24	-	-	NOUN
dti-1336	50	25	asparaginase	asparaginase	ADJ
dti-1336	50	26	,	,	PUNCT
dti-1336	50	27	methotrexate	methotrexate	NOUN
dti-1336	50	28	,	,	PUNCT
dti-1336	50	29	fl	fl	NOUN
dti-1336	50	30	uorouracil	uorouracil	NOUN
dti-1336	50	31	,	,	PUNCT
dti-1336	50	32	cyclophosphamide.15	cyclophosphamide.15	NOUN
dti-1336	50	33	protein	protein	NOUN
dti-1336	50	34	s	s	PART
dti-1336	50	35	defi	defi	NOUN
dti-1336	50	36	ciency	ciency	NOUN
dti-1336	50	37	is	be	AUX
dti-1336	50	38	a	a	DET
dti-1336	50	39	common	common	ADJ
dti-1336	50	40	thrombophilic	thrombophilic	NOUN
dti-1336	50	41	abnormality	abnormality	NOUN
dti-1336	50	42	that	that	PRON
dti-1336	50	43	can	can	AUX
dti-1336	50	44	originate	originate	VERB
dti-1336	50	45	both	both	PRON
dti-1336	50	46	from	from	ADP
dti-1336	50	47	a	a	DET
dti-1336	50	48	congenital	congenital	ADJ
dti-1336	50	49	genetic	genetic	ADJ
dti-1336	50	50	defect	defect	NOUN
dti-1336	50	51	or	or	CCONJ
dti-1336	50	52	,	,	PUNCT
dti-1336	50	53	more	more	ADV
dti-1336	50	54	often	often	ADV
dti-1336	50	55	,	,	PUNCT
dti-1336	50	56	from	from	ADP
dti-1336	50	57	acquired	acquire	VERB
dti-1336	50	58	plasma	plasma	NOUN
dti-1336	50	59	perturbations	perturbation	NOUN
dti-1336	50	60	.	.	PUNCT
dti-1336	51	1	inherited	inherit	VERB
dti-1336	51	2	heterozygotes	heterozygote	NOUN
dti-1336	51	3	prevalence	prevalence	NOUN
dti-1336	51	4	at	at	ADP
dti-1336	51	5	fi	fi	NOUN
dti-1336	51	6	rst	rst	PROPN
dti-1336	51	7	thrombotic	thrombotic	ADJ
dti-1336	51	8	episode	episode	NOUN
dti-1336	51	9	is	be	AUX
dti-1336	51	10	between	between	ADP
dti-1336	51	11	1	1	NUM
dti-1336	51	12	%	%	NOUN
dti-1336	51	13	and	and	CCONJ
dti-1336	51	14	7	7	NUM
dti-1336	51	15	%	%	NOUN
dti-1336	51	16	.	.	PUNCT
dti-1336	52	1	patients	patient	NOUN
dti-1336	52	2	with	with	ADP
dti-1336	52	3	protein	protein	NOUN
dti-1336	52	4	s	s	PART
dti-1336	52	5	defi	defi	NOUN
dti-1336	52	6	ciency	ciency	NOUN
dti-1336	52	7	have	have	VERB
dti-1336	52	8	an	an	DET
dti-1336	52	9	increased	increase	VERB
dti-1336	52	10	risk	risk	NOUN
dti-1336	52	11	of	of	ADP
dti-1336	52	12	vte	vte	NOUN
dti-1336	52	13	but	but	CCONJ
dti-1336	52	14	a	a	DET
dti-1336	52	15	clear	clear	ADJ
dti-1336	52	16	association	association	NOUN
dti-1336	52	17	with	with	ADP
dti-1336	52	18	arterial	arterial	ADJ
dti-1336	52	19	thrombosis	thrombosis	NOUN
dti-1336	52	20	has	have	AUX
dti-1336	52	21	not	not	PART
dti-1336	52	22	been	be	AUX
dti-1336	52	23	demonstrated	demonstrate	VERB
dti-1336	52	24	.	.	PUNCT
dti-1336	53	1	heterozygotes	heterozygote	NOUN
dti-1336	53	2	have	have	VERB
dti-1336	53	3	an	an	DET
dti-1336	53	4	8.5	8.5	NUM
dti-1336	53	5	times	time	NOUN
dti-1336	53	6	higher	high	ADJ
dti-1336	53	7	risk	risk	NOUN
dti-1336	53	8	of	of	ADP
dti-1336	53	9	developing	develop	VERB
dti-1336	53	10	thrombosis.8	thrombosis.8	PROPN
dti-1336	53	11	neonatal	neonatal	ADJ
dti-1336	53	12	purpura	purpura	NOUN
dti-1336	53	13	fulminans	fulminan	NOUN
dti-1336	53	14	or	or	CCONJ
dti-1336	53	15	recurrent	recurrent	ADJ
dti-1336	53	16	vte	vte	NOUN
dti-1336	53	17	at	at	ADP
dti-1336	53	18	a	a	DET
dti-1336	53	19	young	young	ADJ
dti-1336	53	20	age	age	NOUN
dti-1336	53	21	have	have	AUX
dti-1336	53	22	been	be	AUX
dti-1336	53	23	described	describe	VERB
dti-1336	53	24	in	in	ADP
dti-1336	53	25	homozygotes	homozygote	NOUN
dti-1336	53	26	or	or	CCONJ
dti-1336	53	27	double	double	ADJ
dti-1336	53	28	heterozygotes.18	heterozygotes.18	VERB
dti-1336	53	29	under	under	ADP
dti-1336	53	30	normal	normal	ADJ
dti-1336	53	31	conditions	condition	NOUN
dti-1336	53	32	,	,	PUNCT
dti-1336	53	33	about	about	ADV
dti-1336	53	34	60	60	NUM
dti-1336	53	35	%	%	NOUN
dti-1336	53	36	of	of	ADP
dti-1336	53	37	protein	protein	NOUN
dti-1336	53	38	s	s	VERB
dti-1336	53	39	is	be	AUX
dti-1336	53	40	bound	bind	VERB
dti-1336	53	41	in	in	ADP
dti-1336	53	42	plasma	plasma	NOUN
dti-1336	53	43	to	to	ADP
dti-1336	53	44	c4b	c4b	NUM
dti-1336	53	45	binding	bind	VERB
dti-1336	53	46	protein	protein	NOUN
dti-1336	53	47	(	(	PUNCT
dti-1336	53	48	c4bp	c4bp	NOUN
dti-1336	53	49	)	)	PUNCT
dti-1336	53	50	.	.	PUNCT
dti-1336	54	1	it	it	PRON
dti-1336	54	2	is	be	AUX
dti-1336	54	3	generally	generally	ADV
dti-1336	54	4	accepted	accept	VERB
dti-1336	54	5	that	that	SCONJ
dti-1336	54	6	only	only	ADV
dti-1336	54	7	the	the	DET
dti-1336	54	8	free	free	ADJ
dti-1336	54	9	protein	protein	NOUN
dti-1336	54	10	s	s	PART
dti-1336	54	11	(	(	PUNCT
dti-1336	54	12	about	about	ADV
dti-1336	54	13	40	40	NUM
dti-1336	54	14	%	%	NOUN
dti-1336	54	15	of	of	ADP
dti-1336	54	16	the	the	DET
dti-1336	54	17	total	total	NOUN
dti-1336	54	18	)	)	PUNCT
dti-1336	54	19	is	be	AUX
dti-1336	54	20	functionally	functionally	ADV
dti-1336	54	21	active	active	ADJ
dti-1336	54	22	,	,	PUNCT
dti-1336	54	23	consequently	consequently	ADV
dti-1336	54	24	an	an	DET
dti-1336	54	25	increase	increase	NOUN
dti-1336	54	26	of	of	ADP
dti-1336	54	27	c4bp	c4bp	NOUN
dti-1336	54	28	levels	level	NOUN
dti-1336	54	29	produces	produce	VERB
dti-1336	54	30	a	a	DET
dti-1336	54	31	reduced	reduced	ADJ
dti-1336	54	32	protein	protein	NOUN
dti-1336	54	33	s	s	PART
dti-1336	54	34	activity	activity	NOUN
dti-1336	54	35	,	,	PUNCT
dti-1336	54	36	despite	despite	SCONJ
dti-1336	54	37	normal	normal	ADJ
dti-1336	54	38	antigen	antigen	NOUN
dti-1336	54	39	levels.19	levels.19	NOUN
dti-1336	54	40	recent	recent	ADJ
dti-1336	54	41	report	report	NOUN
dti-1336	54	42	never	never	ADV
dti-1336	54	43	less	less	ADJ
dti-1336	54	44	has	have	AUX
dti-1336	54	45	shown	show	VERB
dti-1336	54	46	that	that	SCONJ
dti-1336	54	47	protein	protein	NOUN
dti-1336	54	48	s	s	NOUN
dti-1336	54	49	-	-	PUNCT
dti-1336	54	50	c4b	c4b	ADJ
dti-1336	54	51	couples	couple	NOUN
dti-1336	54	52	retain	retain	VERB
dti-1336	54	53	apc	apc	NOUN
dti-1336	54	54	cofactor	cofactor	NOUN
dti-1336	54	55	activity	activity	NOUN
dti-1336	54	56	(	(	PUNCT
dti-1336	54	57	20	20	NUM
dti-1336	54	58	)	)	PUNCT
dti-1336	54	59	.	.	PUNCT
dti-1336	55	1	total	total	ADJ
dti-1336	55	2	protein	protein	NOUN
dti-1336	55	3	s	s	PART
dti-1336	55	4	levels	level	NOUN
dti-1336	55	5	are	be	AUX
dti-1336	55	6	15	15	NUM
dti-1336	55	7	%	%	NOUN
dti-1336	55	8	to	to	PART
dti-1336	55	9	30	30	NUM
dti-1336	55	10	%	%	NOUN
dti-1336	55	11	of	of	ADP
dti-1336	55	12	normal	normal	ADJ
dti-1336	55	13	in	in	ADP
dti-1336	55	14	healthy	healthy	ADJ
dti-1336	55	15	newborns	newborn	NOUN
dti-1336	55	16	,	,	PUNCT
dti-1336	55	17	but	but	CCONJ
dti-1336	55	18	c4bp	c4bp	X
dti-1336	55	19	is	be	AUX
dti-1336	55	20	also	also	ADV
dti-1336	55	21	reduced	reduce	VERB
dti-1336	55	22	(	(	PUNCT
dti-1336	55	23	20	20	NUM
dti-1336	55	24	%	%	NOUN
dti-1336	55	25	of	of	ADP
dti-1336	55	26	normal	normal	ADJ
dti-1336	55	27	levels	level	NOUN
dti-1336	55	28	)	)	PUNCT
dti-1336	55	29	,	,	PUNCT
dti-1336	55	30	with	with	ADP
dti-1336	55	31	only	only	ADV
dti-1336	55	32	slightly	slightly	ADV
dti-1336	55	33	reduced	reduce	VERB
dti-1336	55	34	functional	functional	ADJ
dti-1336	55	35	level	level	NOUN
dti-1336	55	36	compared	compare	VERB
dti-1336	55	37	to	to	ADP
dti-1336	55	38	adults	adult	NOUN
dti-1336	55	39	.	.	PUNCT
dti-1336	56	1	acquired	acquire	VERB
dti-1336	56	2	defi	defi	NOUN
dti-1336	56	3	ciency	ciency	NOUN
dti-1336	56	4	of	of	ADP
dti-1336	56	5	protein	protein	NOUN
dti-1336	56	6	s	s	VERB
dti-1336	56	7	is	be	AUX
dti-1336	56	8	observed	observe	VERB
dti-1336	56	9	during	during	ADP
dti-1336	56	10	pregnancy	pregnancy	NOUN
dti-1336	56	11	,	,	PUNCT
dti-1336	56	12	oral	oral	ADJ
dti-1336	56	13	contraceptive	contraceptive	ADJ
dti-1336	56	14	use	use	NOUN
dti-1336	56	15	,	,	PUNCT
dti-1336	56	16	during	during	ADP
dti-1336	56	17	an	an	DET
dti-1336	56	18	acute	acute	ADJ
dti-1336	56	19	thromboembolic	thromboembolic	NOUN
dti-1336	56	20	disease	disease	NOUN
dti-1336	56	21	,	,	PUNCT
dti-1336	56	22	anticoagulant	anticoagulant	NOUN
dti-1336	56	23	therapy	therapy	NOUN
dti-1336	56	24	,	,	PUNCT
dti-1336	56	25	dic	dic	ADJ
dti-1336	56	26	and	and	CCONJ
dti-1336	56	27	liver	liver	NOUN
dti-1336	56	28	diseases.20	diseases.20	ADJ
dti-1336	56	29	free	free	ADJ
dti-1336	56	30	protein	protein	NOUN
dti-1336	56	31	s	s	VERB
dti-1336	56	32	antigen	antigen	ADJ
dti-1336	56	33	and	and	CCONJ
dti-1336	56	34	functional	functional	ADJ
dti-1336	56	35	activity	activity	NOUN
dti-1336	56	36	can	can	AUX
dti-1336	56	37	decrease	decrease	VERB
dti-1336	56	38	during	during	ADP
dti-1336	56	39	infl	infl	PROPN
dti-1336	56	40	ammatory	ammatory	NOUN
dti-1336	56	41	disorders	disorder	NOUN
dti-1336	56	42	,	,	PUNCT
dti-1336	56	43	possibly	possibly	ADV
dti-1336	56	44	due	due	ADP
dti-1336	56	45	to	to	ADP
dti-1336	56	46	higher	high	ADJ
dti-1336	56	47	levels	level	NOUN
dti-1336	56	48	of	of	ADP
dti-1336	56	49	c4bp.21	c4bp.21	ADJ
dti-1336	56	50	symptomatic	symptomatic	ADJ
dti-1336	56	51	cases	case	NOUN
dti-1336	56	52	should	should	AUX
dti-1336	56	53	be	be	AUX
dti-1336	56	54	treated	treat	VERB
dti-1336	56	55	with	with	ADP
dti-1336	56	56	full	full	ADJ
dti-1336	56	57	anticoagulation	anticoagulation	NOUN
dti-1336	56	58	;	;	PUNCT
dti-1336	56	59	like	like	ADP
dti-1336	56	60	for	for	ADP
dti-1336	56	61	protein	protein	NOUN
dti-1336	56	62	c	c	PROPN
dti-1336	56	63	defi	defi	NOUN
dti-1336	56	64	ciency	ciency	NOUN
dti-1336	56	65	,	,	PUNCT
dti-1336	56	66	warfarin	warfarin	NOUN
dti-1336	56	67	treatment	treatment	NOUN
dti-1336	56	68	should	should	AUX
dti-1336	56	69	start	start	VERB
dti-1336	56	70	at	at	ADP
dti-1336	56	71	a	a	DET
dti-1336	56	72	low	low	ADJ
dti-1336	56	73	dose	dose	NOUN
dti-1336	56	74	and	and	CCONJ
dti-1336	56	75	only	only	ADV
dti-1336	56	76	after	after	ADP
dti-1336	56	77	full	full	ADJ
dti-1336	56	78	heparinization	heparinization	NOUN
dti-1336	56	79	.	.	PUNCT
dti-1336	57	1	factor	factor	NOUN
dti-1336	57	2	v	v	NUM
dti-1336	57	3	leiden	leiden	PROPN
dti-1336	57	4	mutation	mutation	NOUN
dti-1336	57	5	the	the	DET
dti-1336	57	6	most	most	ADV
dti-1336	57	7	common	common	ADJ
dti-1336	57	8	inherited	inherit	VERB
dti-1336	57	9	prothrombotic	prothrombotic	ADJ
dti-1336	57	10	condition	condition	NOUN
dti-1336	57	11	is	be	AUX
dti-1336	57	12	due	due	ADJ
dti-1336	57	13	to	to	ADP
dti-1336	57	14	a	a	DET
dti-1336	57	15	mutation	mutation	NOUN
dti-1336	57	16	of	of	ADP
dti-1336	57	17	factor	factor	NOUN
dti-1336	57	18	v	v	NOUN
dti-1336	57	19	,	,	PUNCT
dti-1336	57	20	called	call	VERB
dti-1336	57	21	factor	factor	NOUN
dti-1336	57	22	v	v	NOUN
dti-1336	57	23	leiden	leiden	PROPN
dti-1336	57	24	.	.	PUNCT
dti-1336	58	1	the	the	DET
dti-1336	58	2	mutation	mutation	NOUN
dti-1336	58	3	is	be	AUX
dti-1336	58	4	at	at	ADP
dti-1336	58	5	the	the	DET
dti-1336	58	6	cleavage	cleavage	NOUN
dti-1336	58	7	site	site	NOUN
dti-1336	58	8	,	,	PUNCT
dti-1336	58	9	where	where	SCONJ
dti-1336	58	10	apc	apc	PROPN
dti-1336	58	11	inactivates	inactivate	VERB
dti-1336	58	12	factor	factor	PROPN
dti-1336	58	13	va	va	PROPN
dti-1336	58	14	.	.	PUNCT
dti-1336	59	1	this	this	DET
dti-1336	59	2	single	single	ADJ
dti-1336	59	3	point	point	NOUN
dti-1336	59	4	mutation	mutation	NOUN
dti-1336	59	5	leads	lead	VERB
dti-1336	59	6	factor	factor	NOUN
dti-1336	59	7	v	v	PROPN
dti-1336	59	8	leiden	leiden	PROPN
dti-1336	59	9	to	to	PART
dti-1336	59	10	be	be	AUX
dti-1336	59	11	relatively	relatively	ADV
dti-1336	59	12	resistant	resistant	ADJ
dti-1336	59	13	to	to	ADP
dti-1336	59	14	proteolytic	proteolytic	ADJ
dti-1336	59	15	inactivation	inactivation	NOUN
dti-1336	59	16	by	by	ADP
dti-1336	59	17	apc	apc	PROPN
dti-1336	59	18	.	.	PUNCT
dti-1336	60	1	the	the	DET
dti-1336	60	2	slower	slow	ADJ
dti-1336	60	3	inactivation	inactivation	NOUN
dti-1336	60	4	of	of	ADP
dti-1336	60	5	factor	factor	NOUN
dti-1336	60	6	va	va	PROPN
dti-1336	60	7	results	result	NOUN
dti-1336	60	8	in	in	ADP
dti-1336	60	9	its	its	PRON
dti-1336	60	10	persistent	persistent	ADJ
dti-1336	60	11	presence	presence	NOUN
dti-1336	60	12	in	in	ADP
dti-1336	60	13	the	the	DET
dti-1336	60	14	blood	blood	NOUN
dti-1336	60	15	,	,	PUNCT
dti-1336	60	16	producing	produce	VERB
dti-1336	60	17	a	a	DET
dti-1336	60	18	prothrombotic	prothrombotic	ADJ
dti-1336	60	19	state	state	NOUN
dti-1336	60	20	.	.	PUNCT
dti-1336	61	1	this	this	DET
dti-1336	61	2	defect	defect	NOUN
dti-1336	61	3	was	be	AUX
dti-1336	61	4	identifi	identifi	PROPN
dti-1336	61	5	ed	ed	NOUN
dti-1336	61	6	in	in	ADP
dti-1336	61	7	1993	1993	NUM
dti-1336	61	8	,	,	PUNCT
dti-1336	61	9	when	when	SCONJ
dti-1336	61	10	dahlbäck	dahlbäck	NOUN
dti-1336	61	11	observed	observe	VERB
dti-1336	61	12	that	that	SCONJ
dti-1336	61	13	plasma	plasma	NOUN
dti-1336	61	14	from	from	ADP
dti-1336	61	15	a	a	DET
dti-1336	61	16	patient	patient	NOUN
dti-1336	61	17	with	with	ADP
dti-1336	61	18	a	a	DET
dti-1336	61	19	personal	personal	ADJ
dti-1336	61	20	and	and	CCONJ
dti-1336	61	21	family	family	NOUN
dti-1336	61	22	history	history	NOUN
dti-1336	61	23	of	of	ADP
dti-1336	61	24	vte	vte	NOUN
dti-1336	61	25	showed	show	VERB
dti-1336	61	26	a	a	DET
dti-1336	61	27	reduced	reduced	ADJ
dti-1336	61	28	response	response	NOUN
dti-1336	61	29	to	to	ADP
dti-1336	61	30	the	the	DET
dti-1336	61	31	addition	addition	NOUN
dti-1336	61	32	of	of	ADP
dti-1336	61	33	apc	apc	PROPN
dti-1336	61	34	in	in	ADP
dti-1336	61	35	an	an	DET
dti-1336	61	36	aptt	aptt	ADV
dti-1336	61	37	-	-	PUNCT
dti-1336	61	38	based	base	VERB
dti-1336	61	39	test	test	NOUN
dti-1336	61	40	.	.	PUNCT
dti-1336	62	1	this	this	DET
dti-1336	62	2	phenomenon	phenomenon	NOUN
dti-1336	62	3	called	call	VERB
dti-1336	62	4	apc	apc	PROPN
dti-1336	62	5	resistance	resistance	NOUN
dti-1336	63	1	has	have	AUX
dti-1336	63	2	been	be	AUX
dti-1336	63	3	associated	associate	VERB
dti-1336	63	4	in	in	ADP
dti-1336	63	5	most	most	ADJ
dti-1336	63	6	cases	case	NOUN
dti-1336	63	7	to	to	ADP
dti-1336	63	8	a	a	DET
dti-1336	63	9	single	single	ADJ
dti-1336	63	10	amino	amino	NOUN
dti-1336	63	11	acid	acid	NOUN
dti-1336	63	12	substitution	substitution	NOUN
dti-1336	63	13	(	(	PUNCT
dti-1336	63	14	arg	arg	NOUN
dti-1336	63	15	residue	residue	NOUN
dti-1336	63	16	at	at	ADP
dti-1336	63	17	position	position	NOUN
dti-1336	63	18	506	506	NUM
dti-1336	63	19	is	be	AUX
dti-1336	63	20	replaced	replace	VERB
dti-1336	63	21	by	by	ADP
dti-1336	63	22	gln).22,23	gln).22,23	PROPN
dti-1336	63	23	the	the	DET
dti-1336	63	24	prevalence	prevalence	NOUN
dti-1336	63	25	of	of	ADP
dti-1336	63	26	this	this	DET
dti-1336	63	27	mutation	mutation	NOUN
dti-1336	63	28	in	in	ADP
dti-1336	63	29	the	the	DET
dti-1336	63	30	general	general	ADJ
dti-1336	63	31	caucasian	caucasian	ADJ
dti-1336	63	32	population	population	NOUN
dti-1336	63	33	is	be	AUX
dti-1336	63	34	between	between	ADP
dti-1336	63	35	1	1	NUM
dti-1336	63	36	%	%	NOUN
dti-1336	63	37	and	and	CCONJ
dti-1336	63	38	7	7	NUM
dti-1336	63	39	%	%	NOUN
dti-1336	63	40	,	,	PUNCT
dti-1336	63	41	while	while	SCONJ
dti-1336	63	42	it	it	PRON
dti-1336	63	43	is	be	AUX
dti-1336	63	44	very	very	ADV
dti-1336	63	45	rare	rare	ADJ
dti-1336	63	46	in	in	ADP
dti-1336	63	47	other	other	ADJ
dti-1336	63	48	ethnic	ethnic	ADJ
dti-1336	63	49	groups.24	groups.24	NOUN
dti-1336	63	50	patients	patient	NOUN
dti-1336	63	51	with	with	ADP
dti-1336	63	52	heterozygous	heterozygous	ADJ
dti-1336	63	53	factor	factor	NOUN
dti-1336	63	54	v	v	ADP
dti-1336	63	55	leiden	leiden	PROPN
dti-1336	63	56	mutation	mutation	NOUN
dti-1336	63	57	have	have	VERB
dti-1336	63	58	a	a	DET
dti-1336	63	59	relative	relative	ADJ
dti-1336	63	60	risk	risk	NOUN
dti-1336	63	61	7	7	NUM
dti-1336	63	62	-	-	ADJ
dti-1336	63	63	fold	fold	ADV
dti-1336	63	64	increased	increase	VERB
dti-1336	63	65	in	in	ADP
dti-1336	63	66	overall	overall	ADJ
dti-1336	63	67	risk	risk	NOUN
dti-1336	63	68	of	of	ADP
dti-1336	63	69	vte	vte	NOUN
dti-1336	63	70	(	(	PUNCT
dti-1336	63	71	relative	relative	ADJ
dti-1336	63	72	risk	risk	NOUN
dti-1336	63	73	corrected	correct	VERB
dti-1336	63	74	for	for	ADP
dti-1336	63	75	sex	sex	NOUN
dti-1336	63	76	and	and	CCONJ
dti-1336	63	77	family	family	NOUN
dti-1336	63	78	status	status	NOUN
dti-1336	63	79	is	be	AUX
dti-1336	63	80	2.2),8	2.2),8	NUM
dti-1336	63	81	relative	relative	ADJ
dti-1336	63	82	risk	risk	NOUN
dti-1336	63	83	increases	increase	VERB
dti-1336	63	84	to	to	ADP
dti-1336	63	85	50–80	50–80	NUM
dti-1336	63	86	fold	fold	NOUN
dti-1336	63	87	in	in	ADP
dti-1336	63	88	homozygous	homozygous	ADJ
dti-1336	63	89	patients.25,26	patients.25,26	NOUN
dti-1336	63	90	compared	compare	VERB
dti-1336	63	91	with	with	ADP
dti-1336	63	92	defi	defi	NOUN
dti-1336	63	93	ciency	ciency	NOUN
dti-1336	63	94	of	of	ADP
dti-1336	63	95	natural	natural	ADJ
dti-1336	63	96	anticoagulants	anticoagulant	NOUN
dti-1336	63	97	,	,	PUNCT
dti-1336	63	98	factor	factor	NOUN
dti-1336	63	99	v	v	PROPN
dti-1336	63	100	leiden	leiden	PROPN
dti-1336	63	101	is	be	AUX
dti-1336	63	102	a	a	DET
dti-1336	63	103	weaker	weak	ADJ
dti-1336	63	104	risk	risk	NOUN
dti-1336	63	105	factor	factor	NOUN
dti-1336	63	106	for	for	ADP
dti-1336	63	107	vte	vte	NOUN
dti-1336	63	108	,	,	PUNCT
dti-1336	63	109	but	but	CCONJ
dti-1336	63	110	it	it	PRON
dti-1336	63	111	is	be	AUX
dti-1336	63	112	far	far	ADV
dti-1336	63	113	more	more	ADV
dti-1336	63	114	common	common	ADJ
dti-1336	63	115	,	,	PUNCT
dti-1336	63	116	as	as	SCONJ
dti-1336	63	117	it	it	PRON
dti-1336	63	118	can	can	AUX
dti-1336	63	119	be	be	AUX
dti-1336	63	120	found	find	VERB
dti-1336	63	121	in	in	ADP
dti-1336	63	122	about	about	ADV
dti-1336	63	123	20	20	NUM
dti-1336	63	124	%	%	NOUN
dti-1336	63	125	of	of	ADP
dti-1336	63	126	patients	patient	NOUN
dti-1336	63	127	with	with	ADP
dti-1336	63	128	venous	venous	ADJ
dti-1336	63	129	thrombosis	thrombosis	NOUN
dti-1336	63	130	.	.	PUNCT
dti-1336	64	1	homozygotes	homozygote	NOUN
dti-1336	64	2	are	be	AUX
dti-1336	64	3	not	not	PART
dti-1336	64	4	so	so	ADV
dti-1336	64	5	rare	rare	ADJ
dti-1336	64	6	,	,	PUNCT
dti-1336	64	7	with	with	SCONJ
dti-1336	64	8	a	a	DET
dti-1336	64	9	prevalence	prevalence	NOUN
dti-1336	64	10	of	of	ADP
dti-1336	64	11	1/500	1/500	NUM
dti-1336	64	12	in	in	ADP
dti-1336	64	13	the	the	DET
dti-1336	64	14	general	general	ADJ
dti-1336	64	15	population.26	population.26	NOUN
dti-1336	64	16	the	the	DET
dti-1336	64	17	main	main	ADJ
dti-1336	64	18	clinical	clinical	ADJ
dti-1336	64	19	manifestation	manifestation	NOUN
dti-1336	64	20	of	of	ADP
dti-1336	64	21	this	this	DET
dti-1336	64	22	defect	defect	NOUN
dti-1336	64	23	is	be	AUX
dti-1336	64	24	the	the	DET
dti-1336	64	25	increased	increase	VERB
dti-1336	64	26	vte	vte	NOUN
dti-1336	64	27	development	development	NOUN
dti-1336	64	28	.	.	PUNCT
dti-1336	65	1	of	of	ADP
dti-1336	65	2	particular	particular	ADJ
dti-1336	65	3	interest	interest	NOUN
dti-1336	65	4	is	be	AUX
dti-1336	65	5	the	the	DET
dti-1336	65	6	observation	observation	NOUN
dti-1336	65	7	of	of	ADP
dti-1336	65	8	a	a	DET
dti-1336	65	9	high	high	ADJ
dti-1336	65	10	incidence	incidence	NOUN
dti-1336	65	11	of	of	ADP
dti-1336	65	12	vte	vte	NOUN
dti-1336	65	13	in	in	ADP
dti-1336	65	14	women	woman	NOUN
dti-1336	65	15	with	with	ADP
dti-1336	65	16	factor	factor	NOUN
dti-1336	65	17	v	v	NUM
dti-1336	65	18	leiden	leiden	PROPN
dti-1336	65	19	mutation	mutation	NOUN
dti-1336	65	20	taking	take	VERB
dti-1336	65	21	oral	oral	ADJ
dti-1336	65	22	contraceptives	contraceptive	NOUN
dti-1336	65	23	;	;	PUNCT
dti-1336	65	24	in	in	ADP
dti-1336	65	25	these	these	DET
dti-1336	65	26	cases	case	NOUN
dti-1336	65	27	the	the	DET
dti-1336	65	28	risk	risk	NOUN
dti-1336	65	29	of	of	ADP
dti-1336	65	30	thrombosis	thrombosis	NOUN
dti-1336	65	31	91	91	NUM
dti-1336	65	32	thrombophilia	thrombophilia	NOUN
dti-1336	65	33	drug	drug	NOUN
dti-1336	65	34	target	target	NOUN
dti-1336	65	35	insights	insight	NOUN
dti-1336	65	36	2008:3	2008:3	NUM
dti-1336	65	37	is	be	AUX
dti-1336	65	38	35	35	NUM
dti-1336	65	39	fold	fold	ADJ
dti-1336	65	40	higher.27	higher.27	PROPN
dti-1336	65	41	discordant	discordant	ADJ
dti-1336	65	42	results	result	NOUN
dti-1336	65	43	have	have	AUX
dti-1336	65	44	been	be	AUX
dti-1336	65	45	obtained	obtain	VERB
dti-1336	65	46	from	from	ADP
dti-1336	65	47	different	different	ADJ
dti-1336	65	48	studies	study	NOUN
dti-1336	65	49	testing	test	VERB
dti-1336	65	50	the	the	DET
dti-1336	65	51	correlation	correlation	NOUN
dti-1336	65	52	between	between	ADP
dti-1336	65	53	factor	factor	NOUN
dti-1336	65	54	v	v	ADP
dti-1336	65	55	leiden	leiden	PROPN
dti-1336	65	56	and	and	CCONJ
dti-1336	65	57	the	the	DET
dti-1336	65	58	risk	risk	NOUN
dti-1336	65	59	of	of	ADP
dti-1336	65	60	myocardial	myocardial	ADJ
dti-1336	65	61	infarct	infarct	NOUN
dti-1336	65	62	or	or	CCONJ
dti-1336	65	63	arterial	arterial	ADJ
dti-1336	65	64	thrombosis	thrombosis	NOUN
dti-1336	65	65	:	:	PUNCT
dti-1336	65	66	it	it	PRON
dti-1336	65	67	seems	seem	VERB
dti-1336	65	68	that	that	SCONJ
dti-1336	65	69	factor	factor	NOUN
dti-1336	65	70	v	v	NOUN
dti-1336	65	71	leiden	leiden	PROPN
dti-1336	65	72	can	can	AUX
dti-1336	65	73	increase	increase	VERB
dti-1336	65	74	the	the	DET
dti-1336	65	75	risk	risk	NOUN
dti-1336	65	76	of	of	ADP
dti-1336	65	77	arterial	arterial	ADJ
dti-1336	65	78	events	event	NOUN
dti-1336	65	79	only	only	ADV
dti-1336	65	80	in	in	ADP
dti-1336	65	81	patients	patient	NOUN
dti-1336	65	82	with	with	ADP
dti-1336	65	83	an	an	DET
dti-1336	65	84	already	already	ADV
dti-1336	65	85	present	present	ADJ
dti-1336	65	86	cardiovascular	cardiovascular	ADJ
dti-1336	65	87	risk	risk	NOUN
dti-1336	65	88	factor	factor	NOUN
dti-1336	65	89	like	like	ADP
dti-1336	65	90	cigarette	cigarette	NOUN
dti-1336	65	91	smoking.28	smoking.28	NOUN
dti-1336	65	92	the	the	DET
dti-1336	65	93	presence	presence	NOUN
dti-1336	65	94	of	of	ADP
dti-1336	65	95	factor	factor	NOUN
dti-1336	65	96	v	v	PROPN
dti-1336	65	97	leiden	leiden	PROPN
dti-1336	65	98	mutation	mutation	NOUN
dti-1336	65	99	,	,	PUNCT
dti-1336	65	100	as	as	ADV
dti-1336	65	101	well	well	ADV
dti-1336	65	102	as	as	ADP
dti-1336	65	103	other	other	ADJ
dti-1336	65	104	hereditary	hereditary	ADJ
dti-1336	65	105	thrombophilic	thrombophilic	NOUN
dti-1336	65	106	factors	factor	NOUN
dti-1336	65	107	,	,	PUNCT
dti-1336	65	108	has	have	AUX
dti-1336	65	109	been	be	AUX
dti-1336	65	110	associated	associate	VERB
dti-1336	65	111	with	with	ADP
dti-1336	65	112	a	a	DET
dti-1336	65	113	high	high	ADJ
dti-1336	65	114	risk	risk	NOUN
dti-1336	65	115	of	of	ADP
dti-1336	65	116	fetal	fetal	ADJ
dti-1336	65	117	loss.29	loss.29	PROPN
dti-1336	65	118	resistance	resistance	NOUN
dti-1336	65	119	to	to	ADP
dti-1336	65	120	apc	apc	PROPN
dti-1336	65	121	is	be	AUX
dti-1336	65	122	caused	cause	VERB
dti-1336	65	123	in	in	ADP
dti-1336	65	124	most	most	ADJ
dti-1336	65	125	cases	case	NOUN
dti-1336	65	126	by	by	ADP
dti-1336	65	127	the	the	DET
dti-1336	65	128	factor	factor	NOUN
dti-1336	65	129	v	v	PROPN
dti-1336	65	130	leiden	leiden	PROPN
dti-1336	65	131	mutation	mutation	NOUN
dti-1336	65	132	;	;	PUNCT
dti-1336	65	133	however	however	ADV
dti-1336	65	134	,	,	PUNCT
dti-1336	65	135	an	an	DET
dti-1336	65	136	acquired	acquire	VERB
dti-1336	65	137	state	state	NOUN
dti-1336	65	138	without	without	ADP
dti-1336	65	139	any	any	DET
dti-1336	65	140	genetic	genetic	ADJ
dti-1336	65	141	mutation	mutation	NOUN
dti-1336	65	142	(	(	PUNCT
dti-1336	65	143	acquired	acquire	VERB
dti-1336	65	144	apc	apc	PROPN
dti-1336	65	145	resistance	resistance	PROPN
dti-1336	65	146	)	)	PUNCT
dti-1336	65	147	has	have	AUX
dti-1336	65	148	been	be	AUX
dti-1336	65	149	associated	associate	VERB
dti-1336	65	150	to	to	ADP
dti-1336	65	151	pregnancy	pregnancy	NOUN
dti-1336	65	152	,	,	PUNCT
dti-1336	65	153	use	use	NOUN
dti-1336	65	154	of	of	ADP
dti-1336	65	155	estroprogestone	estroprogestone	NOUN
dti-1336	65	156	therapy	therapy	NOUN
dti-1336	65	157	and	and	CCONJ
dti-1336	65	158	cancer	cancer	NOUN
dti-1336	65	159	(	(	PUNCT
dti-1336	65	160	see	see	VERB
dti-1336	65	161	below	below	ADV
dti-1336	65	162	)	)	PUNCT
dti-1336	65	163	.	.	PUNCT
dti-1336	66	1	prothrombin	prothrombin	PROPN
dti-1336	66	2	g20210a	g20210a	PRON
dti-1336	66	3	mutation	mutation	NOUN
dti-1336	66	4	this	this	PRON
dti-1336	66	5	is	be	AUX
dti-1336	66	6	a	a	DET
dti-1336	66	7	quite	quite	ADV
dti-1336	66	8	common	common	ADJ
dti-1336	66	9	mutation	mutation	NOUN
dti-1336	66	10	observed	observe	VERB
dti-1336	66	11	almost	almost	ADV
dti-1336	66	12	exclusively	exclusively	ADV
dti-1336	66	13	in	in	ADP
dti-1336	66	14	caucasian	caucasian	ADJ
dti-1336	66	15	people	people	NOUN
dti-1336	66	16	.	.	PUNCT
dti-1336	67	1	it	it	PRON
dti-1336	67	2	is	be	AUX
dti-1336	67	3	present	present	ADJ
dti-1336	67	4	in	in	ADP
dti-1336	67	5	about	about	ADV
dti-1336	67	6	2	2	NUM
dti-1336	67	7	%	%	NOUN
dti-1336	67	8	of	of	ADP
dti-1336	67	9	healthy	healthy	ADJ
dti-1336	67	10	individuals	individual	NOUN
dti-1336	67	11	and	and	CCONJ
dti-1336	67	12	in	in	ADP
dti-1336	67	13	6	6	NUM
dti-1336	67	14	%	%	NOUN
dti-1336	67	15	of	of	ADP
dti-1336	67	16	patients	patient	NOUN
dti-1336	67	17	with	with	ADP
dti-1336	67	18	vte.30	vte.30	NOUN
dti-1336	67	19	as	as	ADP
dti-1336	67	20	a	a	DET
dti-1336	67	21	consequence	consequence	NOUN
dti-1336	67	22	of	of	ADP
dti-1336	67	23	this	this	DET
dti-1336	67	24	mutation	mutation	NOUN
dti-1336	67	25	,	,	PUNCT
dti-1336	67	26	levels	level	NOUN
dti-1336	67	27	of	of	ADP
dti-1336	67	28	prothrombin	prothrombin	NOUN
dti-1336	67	29	in	in	ADP
dti-1336	67	30	the	the	DET
dti-1336	67	31	blood	blood	NOUN
dti-1336	67	32	are	be	AUX
dti-1336	67	33	increased	increase	VERB
dti-1336	67	34	and	and	CCONJ
dti-1336	67	35	the	the	DET
dti-1336	67	36	risk	risk	NOUN
dti-1336	67	37	of	of	ADP
dti-1336	67	38	vte	vte	NOUN
dti-1336	67	39	is	be	AUX
dti-1336	67	40	3	3	NUM
dti-1336	67	41	times	time	NOUN
dti-1336	67	42	higher	high	ADJ
dti-1336	67	43	in	in	ADP
dti-1336	67	44	patients	patient	NOUN
dti-1336	67	45	with	with	ADP
dti-1336	67	46	this	this	DET
dti-1336	67	47	mutation	mutation	NOUN
dti-1336	67	48	.	.	PUNCT
dti-1336	68	1	this	this	DET
dti-1336	68	2	defect	defect	NOUN
dti-1336	68	3	is	be	AUX
dti-1336	68	4	not	not	PART
dti-1336	68	5	a	a	DET
dti-1336	68	6	risk	risk	NOUN
dti-1336	68	7	factor	factor	NOUN
dti-1336	68	8	for	for	ADP
dti-1336	68	9	arterial	arterial	ADJ
dti-1336	68	10	thrombosis	thrombosis	NOUN
dti-1336	68	11	or	or	CCONJ
dti-1336	68	12	fetal	fetal	ADJ
dti-1336	68	13	loss.31	loss.31	NOUN
dti-1336	68	14	mthfr	mthfr	PROPN
dti-1336	68	15	mutation	mutation	NOUN
dti-1336	68	16	the	the	DET
dti-1336	68	17	gene	gene	NOUN
dti-1336	68	18	for	for	ADP
dti-1336	68	19	methylenetetrahydrofl	methylenetetrahydrofl	NOUN
dti-1336	68	20	ate	eat	VERB
dti-1336	68	21	reductase	reductase	NOUN
dti-1336	68	22	(	(	PUNCT
dti-1336	68	23	mthfr	mthfr	PROPN
dti-1336	68	24	)	)	PUNCT
dti-1336	68	25	plays	play	VERB
dti-1336	68	26	a	a	DET
dti-1336	68	27	role	role	NOUN
dti-1336	68	28	in	in	ADP
dti-1336	68	29	homocysteine	homocysteine	ADJ
dti-1336	68	30	metabolism	metabolism	NOUN
dti-1336	68	31	;	;	PUNCT
dti-1336	68	32	in	in	ADP
dti-1336	68	33	particular	particular	ADJ
dti-1336	68	34	it	it	PRON
dti-1336	68	35	is	be	AUX
dti-1336	68	36	essential	essential	ADJ
dti-1336	68	37	for	for	ADP
dti-1336	68	38	the	the	DET
dti-1336	68	39	methylation	methylation	NOUN
dti-1336	68	40	of	of	ADP
dti-1336	68	41	homocysteine	homocysteine	NOUN
dti-1336	68	42	and	and	CCONJ
dti-1336	68	43	formation	formation	NOUN
dti-1336	68	44	of	of	ADP
dti-1336	68	45	methionine	methionine	NOUN
dti-1336	68	46	.	.	PUNCT
dti-1336	69	1	the	the	DET
dti-1336	69	2	c677	c677	PROPN
dti-1336	69	3	t	t	PROPN
dti-1336	69	4	mutation	mutation	NOUN
dti-1336	69	5	is	be	AUX
dti-1336	69	6	quite	quite	ADV
dti-1336	69	7	common	common	ADJ
dti-1336	69	8	and	and	CCONJ
dti-1336	69	9	has	have	AUX
dti-1336	69	10	been	be	AUX
dti-1336	69	11	shown	show	VERB
dti-1336	69	12	to	to	PART
dti-1336	69	13	be	be	AUX
dti-1336	69	14	associated	associate	VERB
dti-1336	69	15	with	with	ADP
dti-1336	69	16	mildly	mildly	ADV
dti-1336	69	17	elevated	elevate	VERB
dti-1336	69	18	homocysteine	homocysteine	NOUN
dti-1336	69	19	levels	level	NOUN
dti-1336	69	20	.	.	PUNCT
dti-1336	70	1	as	as	SCONJ
dti-1336	70	2	later	later	ADV
dti-1336	70	3	explained	explain	VERB
dti-1336	70	4	,	,	PUNCT
dti-1336	70	5	elevated	elevate	VERB
dti-1336	70	6	homocysterine	homocysterine	ADJ
dti-1336	70	7	levels	level	NOUN
dti-1336	70	8	are	be	AUX
dti-1336	70	9	associated	associate	VERB
dti-1336	70	10	with	with	ADP
dti-1336	70	11	an	an	DET
dti-1336	70	12	increased	increase	VERB
dti-1336	70	13	risk	risk	NOUN
dti-1336	70	14	of	of	ADP
dti-1336	70	15	thrombosis	thrombosis	NOUN
dti-1336	70	16	.	.	PUNCT
dti-1336	71	1	although	although	SCONJ
dti-1336	71	2	this	this	DET
dti-1336	71	3	variant	variant	NOUN
dti-1336	71	4	is	be	AUX
dti-1336	71	5	common	common	ADJ
dti-1336	71	6	(	(	PUNCT
dti-1336	71	7	about	about	ADV
dti-1336	71	8	10	10	NUM
dti-1336	71	9	%	%	NOUN
dti-1336	71	10	of	of	ADP
dti-1336	71	11	the	the	DET
dti-1336	71	12	general	general	ADJ
dti-1336	71	13	population	population	NOUN
dti-1336	71	14	are	be	AUX
dti-1336	71	15	homozygous	homozygous	ADJ
dti-1336	71	16	carriers	carrier	NOUN
dti-1336	71	17	)	)	PUNCT
dti-1336	71	18	,	,	PUNCT
dti-1336	71	19	it	it	PRON
dti-1336	71	20	produces	produce	VERB
dti-1336	71	21	a	a	DET
dti-1336	71	22	slight	slight	ADJ
dti-1336	71	23	elevation	elevation	NOUN
dti-1336	71	24	of	of	ADP
dti-1336	71	25	homocysteine	homocysteine	ADJ
dti-1336	71	26	levels	level	NOUN
dti-1336	71	27	and	and	CCONJ
dti-1336	71	28	only	only	ADV
dti-1336	71	29	a	a	DET
dti-1336	71	30	small	small	ADJ
dti-1336	71	31	number	number	NOUN
dti-1336	71	32	of	of	ADP
dti-1336	71	33	patients	patient	NOUN
dti-1336	71	34	with	with	ADP
dti-1336	71	35	the	the	DET
dti-1336	71	36	homozygous	homozygous	ADJ
dti-1336	71	37	defect	defect	NOUN
dti-1336	71	38	shows	show	VERB
dti-1336	71	39	premature	premature	ADJ
dti-1336	71	40	vascular	vascular	ADJ
dti-1336	71	41	disease	disease	NOUN
dti-1336	71	42	and	and	CCONJ
dti-1336	71	43	thrombosis.32,33	thrombosis.32,33	DET
dti-1336	71	44	a	a	DET
dti-1336	71	45	less	less	ADV
dti-1336	71	46	common	common	ADJ
dti-1336	71	47	genetic	genetic	ADJ
dti-1336	71	48	defect	defect	NOUN
dti-1336	71	49	in	in	ADP
dti-1336	71	50	the	the	DET
dti-1336	71	51	homocysteine	homocysteine	ADJ
dti-1336	71	52	metabolism	metabolism	NOUN
dti-1336	71	53	is	be	AUX
dti-1336	71	54	the	the	DET
dti-1336	71	55	defi	defi	NOUN
dti-1336	71	56	ciency	ciency	NOUN
dti-1336	71	57	of	of	ADP
dti-1336	71	58	cystathionine	cystathionine	NOUN
dti-1336	71	59	-	-	PUNCT
dti-1336	71	60	βsynthase	βsynthase	NOUN
dti-1336	71	61	,	,	PUNCT
dti-1336	71	62	which	which	PRON
dti-1336	71	63	causes	cause	VERB
dti-1336	71	64	elevated	elevated	ADJ
dti-1336	71	65	homocysteine	homocysteine	ADJ
dti-1336	71	66	levels	level	NOUN
dti-1336	71	67	in	in	ADP
dti-1336	71	68	the	the	DET
dti-1336	71	69	blood	blood	NOUN
dti-1336	71	70	and	and	CCONJ
dti-1336	71	71	result	result	VERB
dti-1336	71	72	in	in	ADP
dti-1336	71	73	early	early	ADJ
dti-1336	71	74	death	death	NOUN
dti-1336	71	75	due	due	ADP
dti-1336	71	76	to	to	ADP
dti-1336	71	77	cv	cv	PROPN
dti-1336	71	78	disease	disease	NOUN
dti-1336	71	79	.	.	PUNCT
dti-1336	72	1	factor	factor	NOUN
dti-1336	72	2	xii	xii	PROPN
dti-1336	72	3	defi	defi	PROPN
dti-1336	72	4	ciency	ciency	NOUN
dti-1336	72	5	patients	patient	NOUN
dti-1336	72	6	with	with	ADP
dti-1336	72	7	factor	factor	NOUN
dti-1336	72	8	xii	xii	PROPN
dti-1336	72	9	defi	defi	PROPN
dti-1336	72	10	ciency	ciency	NOUN
dti-1336	72	11	show	show	VERB
dti-1336	72	12	a	a	DET
dti-1336	72	13	prolonged	prolonged	ADJ
dti-1336	72	14	activated	activate	VERB
dti-1336	72	15	partial	partial	ADJ
dti-1336	72	16	thromboplastin	thromboplastin	NOUN
dti-1336	72	17	time	time	NOUN
dti-1336	72	18	(	(	PUNCT
dti-1336	72	19	aptt	aptt	ADV
dti-1336	72	20	)	)	PUNCT
dti-1336	72	21	,	,	PUNCT
dti-1336	72	22	but	but	CCONJ
dti-1336	72	23	they	they	PRON
dti-1336	72	24	do	do	AUX
dti-1336	72	25	not	not	PART
dti-1336	72	26	have	have	VERB
dti-1336	72	27	a	a	DET
dti-1336	72	28	bleeding	bleed	VERB
dti-1336	72	29	diathesis	diathesis	NOUN
dti-1336	72	30	.	.	PUNCT
dti-1336	73	1	an	an	DET
dti-1336	73	2	increased	increase	VERB
dti-1336	73	3	rate	rate	NOUN
dti-1336	73	4	of	of	ADP
dti-1336	73	5	vte	vte	NOUN
dti-1336	73	6	has	have	AUX
dti-1336	73	7	been	be	AUX
dti-1336	73	8	observed	observe	VERB
dti-1336	73	9	in	in	ADP
dti-1336	73	10	subjects	subject	NOUN
dti-1336	73	11	carrying	carry	VERB
dti-1336	73	12	this	this	DET
dti-1336	73	13	abnormality	abnormality	NOUN
dti-1336	73	14	.	.	PUNCT
dti-1336	74	1	the	the	DET
dti-1336	74	2	thrombophilic	thrombophilic	ADJ
dti-1336	74	3	tendency	tendency	NOUN
dti-1336	74	4	associated	associate	VERB
dti-1336	74	5	with	with	ADP
dti-1336	74	6	severe	severe	ADJ
dti-1336	74	7	factor	factor	NOUN
dti-1336	74	8	xii	xii	PROPN
dti-1336	74	9	defi	defi	NOUN
dti-1336	74	10	ciency	ciency	NOUN
dti-1336	74	11	(	(	PUNCT
dti-1336	74	12	�	�	NOUN
dti-1336	74	13	1	1	NUM
dti-1336	74	14	%	%	NOUN
dti-1336	74	15	factor	factor	NOUN
dti-1336	74	16	xii	xii	NOUN
dti-1336	74	17	activity	activity	NOUN
dti-1336	74	18	)	)	PUNCT
dti-1336	74	19	has	have	AUX
dti-1336	74	20	been	be	AUX
dti-1336	74	21	attributed	attribute	VERB
dti-1336	74	22	to	to	ADP
dti-1336	74	23	reduced	reduced	ADJ
dti-1336	74	24	plasma	plasma	NOUN
dti-1336	74	25	fi	fi	NOUN
dti-1336	74	26	brinolytic	brinolytic	ADJ
dti-1336	74	27	activity.34	activity.34	NOUN
dti-1336	74	28	however	however	ADV
dti-1336	74	29	,	,	PUNCT
dti-1336	74	30	different	different	ADJ
dti-1336	74	31	rates	rate	NOUN
dti-1336	74	32	of	of	ADP
dti-1336	74	33	vte	vte	NOUN
dti-1336	74	34	have	have	AUX
dti-1336	74	35	been	be	AUX
dti-1336	74	36	reported	report	VERB
dti-1336	74	37	in	in	ADP
dti-1336	74	38	different	different	ADJ
dti-1336	74	39	studies	study	NOUN
dti-1336	74	40	including	include	VERB
dti-1336	74	41	patients	patient	NOUN
dti-1336	74	42	with	with	ADP
dti-1336	74	43	factor	factor	NOUN
dti-1336	74	44	xii	xii	PROPN
dti-1336	74	45	defi	defi	NOUN
dti-1336	74	46	ciency	ciency	NOUN
dti-1336	74	47	and	and	CCONJ
dti-1336	74	48	a	a	DET
dti-1336	74	49	clear	clear	ADJ
dti-1336	74	50	role	role	NOUN
dti-1336	74	51	of	of	ADP
dti-1336	74	52	this	this	DET
dti-1336	74	53	defect	defect	NOUN
dti-1336	74	54	for	for	ADP
dti-1336	74	55	the	the	DET
dti-1336	74	56	risk	risk	NOUN
dti-1336	74	57	of	of	ADP
dti-1336	74	58	vte	vte	NOUN
dti-1336	74	59	has	have	AUX
dti-1336	74	60	not	not	PART
dti-1336	74	61	been	be	AUX
dti-1336	74	62	established.35,36	established.35,36	NOUN
dti-1336	74	63	dysfi	dysfi	PROPN
dti-1336	74	64	brinogenemias	brinogenemias	PROPN
dti-1336	74	65	this	this	DET
dti-1336	74	66	group	group	NOUN
dti-1336	74	67	of	of	ADP
dti-1336	74	68	disorders	disorder	NOUN
dti-1336	74	69	is	be	AUX
dti-1336	74	70	characterized	characterize	VERB
dti-1336	74	71	by	by	ADP
dti-1336	74	72	qualitative	qualitative	ADJ
dti-1336	74	73	abnormalities	abnormality	NOUN
dti-1336	74	74	of	of	ADP
dti-1336	74	75	fi	fi	NOUN
dti-1336	74	76	brinogen	brinogen	NOUN
dti-1336	74	77	,	,	PUNCT
dti-1336	74	78	usually	usually	ADV
dti-1336	74	79	inherited	inherit	VERB
dti-1336	74	80	in	in	ADP
dti-1336	74	81	an	an	DET
dti-1336	74	82	autosomal	autosomal	ADJ
dti-1336	74	83	dominant	dominant	ADJ
dti-1336	74	84	fashion	fashion	NOUN
dti-1336	74	85	.	.	PUNCT
dti-1336	75	1	some	some	DET
dti-1336	75	2	variants	variant	NOUN
dti-1336	75	3	are	be	AUX
dti-1336	75	4	associated	associate	VERB
dti-1336	75	5	with	with	ADP
dti-1336	75	6	an	an	DET
dti-1336	75	7	increased	increase	VERB
dti-1336	75	8	risk	risk	NOUN
dti-1336	75	9	of	of	ADP
dti-1336	75	10	thrombosis	thrombosis	NOUN
dti-1336	75	11	and	and	CCONJ
dti-1336	75	12	can	can	AUX
dti-1336	75	13	be	be	AUX
dti-1336	75	14	detected	detect	VERB
dti-1336	75	15	by	by	ADP
dti-1336	75	16	a	a	DET
dti-1336	75	17	prolonged	prolonged	ADJ
dti-1336	75	18	thrombin	thrombin	NOUN
dti-1336	75	19	time	time	NOUN
dti-1336	75	20	(	(	PUNCT
dti-1336	75	21	tt	tt	NOUN
dti-1336	75	22	)	)	PUNCT
dti-1336	75	23	and	and	CCONJ
dti-1336	75	24	reptilase	reptilase	NOUN
dti-1336	75	25	time	time	NOUN
dti-1336	75	26	and	and	CCONJ
dti-1336	75	27	by	by	ADP
dti-1336	75	28	the	the	DET
dti-1336	75	29	discrepancy	discrepancy	NOUN
dti-1336	75	30	between	between	ADP
dti-1336	75	31	the	the	DET
dti-1336	75	32	functional	functional	ADJ
dti-1336	75	33	and	and	CCONJ
dti-1336	75	34	the	the	DET
dti-1336	75	35	antigenic	antigenic	ADJ
dti-1336	75	36	levels	level	NOUN
dti-1336	75	37	of	of	ADP
dti-1336	75	38	fi	fi	NOUN
dti-1336	75	39	brinogen.1	brinogen.1	NOUN
dti-1336	75	40	treatment	treatment	NOUN
dti-1336	75	41	treatment	treatment	NOUN
dti-1336	75	42	of	of	ADP
dti-1336	75	43	acute	acute	ADJ
dti-1336	75	44	episodes	episode	NOUN
dti-1336	75	45	of	of	ADP
dti-1336	75	46	vte	vte	NOUN
dti-1336	75	47	begins	begin	VERB
dti-1336	75	48	with	with	ADP
dti-1336	75	49	heparinization	heparinization	NOUN
dti-1336	75	50	to	to	PART
dti-1336	75	51	obtain	obtain	VERB
dti-1336	75	52	a	a	DET
dti-1336	75	53	full	full	ADJ
dti-1336	75	54	coagulation	coagulation	NOUN
dti-1336	75	55	,	,	PUNCT
dti-1336	75	56	that	that	PRON
dti-1336	75	57	can	can	AUX
dti-1336	75	58	be	be	AUX
dti-1336	75	59	switched	switch	VERB
dti-1336	75	60	to	to	ADP
dti-1336	75	61	oral	oral	ADJ
dti-1336	75	62	anticoagulant	anticoagulant	NOUN
dti-1336	75	63	therapy	therapy	NOUN
dti-1336	75	64	with	with	ADP
dti-1336	75	65	inr	inr	PROPN
dti-1336	75	66	in	in	ADP
dti-1336	75	67	range	range	NOUN
dti-1336	75	68	2–3	2–3	NUM
dti-1336	75	69	.	.	PUNCT
dti-1336	76	1	the	the	DET
dti-1336	76	2	decision	decision	NOUN
dti-1336	76	3	to	to	PART
dti-1336	76	4	extend	extend	VERB
dti-1336	76	5	therapy	therapy	NOUN
dti-1336	76	6	beyond	beyond	ADP
dti-1336	76	7	6–12	6–12	NOUN
dti-1336	76	8	months	month	NOUN
dti-1336	76	9	after	after	SCONJ
dti-1336	76	10	a	a	DET
dti-1336	76	11	thrombotic	thrombotic	ADJ
dti-1336	76	12	event	event	NOUN
dti-1336	76	13	must	must	AUX
dti-1336	76	14	be	be	AUX
dti-1336	76	15	made	make	VERB
dti-1336	76	16	on	on	ADP
dti-1336	76	17	an	an	DET
dti-1336	76	18	individual	individual	ADJ
dti-1336	76	19	basis	basis	NOUN
dti-1336	76	20	,	,	PUNCT
dti-1336	76	21	depending	depend	VERB
dti-1336	76	22	on	on	ADP
dti-1336	76	23	the	the	DET
dti-1336	76	24	presence	presence	NOUN
dti-1336	76	25	of	of	ADP
dti-1336	76	26	concomitant	concomitant	ADJ
dti-1336	76	27	transient	transient	ADJ
dti-1336	76	28	risk	risk	NOUN
dti-1336	76	29	factors	factor	NOUN
dti-1336	76	30	,	,	PUNCT
dti-1336	76	31	location	location	NOUN
dti-1336	76	32	and	and	CCONJ
dti-1336	76	33	severity	severity	NOUN
dti-1336	76	34	of	of	ADP
dti-1336	76	35	the	the	DET
dti-1336	76	36	thrombosis	thrombosis	NOUN
dti-1336	76	37	.	.	PUNCT
dti-1336	77	1	the	the	DET
dti-1336	77	2	risk	risk	NOUN
dti-1336	77	3	of	of	ADP
dti-1336	77	4	vte	vte	NOUN
dti-1336	77	5	associated	associate	VERB
dti-1336	77	6	with	with	ADP
dti-1336	77	7	the	the	DET
dti-1336	77	8	inherited	inherit	VERB
dti-1336	77	9	thrombophilic	thrombophilic	NOUN
dti-1336	77	10	defect	defect	NOUN
dti-1336	77	11	should	should	AUX
dti-1336	77	12	be	be	AUX
dti-1336	77	13	weighted	weight	VERB
dti-1336	77	14	against	against	ADP
dti-1336	77	15	the	the	DET
dti-1336	77	16	hemorrhagic	hemorrhagic	NOUN
dti-1336	77	17	risk	risk	NOUN
dti-1336	77	18	associated	associate	VERB
dti-1336	77	19	with	with	ADP
dti-1336	77	20	a	a	DET
dti-1336	77	21	long	long	ADJ
dti-1336	77	22	-	-	PUNCT
dti-1336	77	23	term	term	NOUN
dti-1336	77	24	anticoagulant	anticoagulant	NOUN
dti-1336	77	25	therapy	therapy	NOUN
dti-1336	77	26	.	.	PUNCT
dti-1336	78	1	current	current	ADJ
dti-1336	78	2	guidelines	guideline	NOUN
dti-1336	78	3	suggest	suggest	VERB
dti-1336	78	4	continuing	continue	VERB
dti-1336	78	5	anticoagulation	anticoagulation	NOUN
dti-1336	78	6	for	for	ADP
dti-1336	78	7	individuals	individual	NOUN
dti-1336	78	8	with	with	ADP
dti-1336	78	9	antithrombin	antithrombin	PROPN
dti-1336	78	10	defi	defi	PROPN
dti-1336	78	11	ciency	ciency	NOUN
dti-1336	78	12	and	and	CCONJ
dti-1336	78	13	a	a	DET
dti-1336	78	14	previous	previous	ADJ
dti-1336	78	15	thrombotic	thrombotic	ADJ
dti-1336	78	16	event	event	NOUN
dti-1336	78	17	,	,	PUNCT
dti-1336	78	18	with	with	ADP
dti-1336	78	19	homozygous	homozygous	ADJ
dti-1336	78	20	thrombophilic	thrombophilic	ADJ
dti-1336	78	21	defects	defect	NOUN
dti-1336	78	22	or	or	CCONJ
dti-1336	78	23	with	with	ADP
dti-1336	78	24	two	two	NUM
dti-1336	78	25	or	or	CCONJ
dti-1336	78	26	more	more	ADV
dti-1336	78	27	prothrombotic	prothrombotic	ADJ
dti-1336	78	28	abnormalities	abnormality	NOUN
dti-1336	78	29	(	(	PUNCT
dti-1336	78	30	see	see	VERB
dti-1336	78	31	also	also	ADV
dti-1336	78	32	below).82	below).82	PROPN
dti-1336	78	33	acquired	acquire	VERB
dti-1336	78	34	thrombophilia	thrombophilia	NOUN
dti-1336	78	35	classic	classic	ADJ
dti-1336	78	36	risk	risk	NOUN
dti-1336	78	37	factors	factor	NOUN
dti-1336	78	38	for	for	ADP
dti-1336	78	39	vte	vte	NOUN
dti-1336	78	40	include	include	VERB
dti-1336	78	41	cancer	cancer	NOUN
dti-1336	78	42	,	,	PUNCT
dti-1336	78	43	surgery	surgery	NOUN
dti-1336	78	44	,	,	PUNCT
dti-1336	78	45	prolonged	prolonged	ADJ
dti-1336	78	46	immobilization	immobilization	NOUN
dti-1336	78	47	,	,	PUNCT
dti-1336	78	48	fractures	fracture	NOUN
dti-1336	78	49	,	,	PUNCT
dti-1336	78	50	puerperium	puerperium	NOUN
dti-1336	78	51	,	,	PUNCT
dti-1336	78	52	paralysis	paralysis	NOUN
dti-1336	78	53	,	,	PUNCT
dti-1336	78	54	use	use	NOUN
dti-1336	78	55	of	of	ADP
dti-1336	78	56	oral	oral	ADJ
dti-1336	78	57	contraceptives	contraceptive	NOUN
dti-1336	78	58	,	,	PUNCT
dti-1336	78	59	and	and	CCONJ
dti-1336	78	60	antiphospolipid	antiphospolipid	ADJ
dti-1336	78	61	antibody	antibody	NOUN
dti-1336	78	62	;	;	PUNCT
dti-1336	78	63	these	these	PRON
dti-1336	78	64	may	may	AUX
dti-1336	78	65	trigger	trigger	VERB
dti-1336	78	66	thrombosis	thrombosis	NOUN
dti-1336	78	67	in	in	ADP
dti-1336	78	68	people	people	NOUN
dti-1336	78	69	with	with	ADP
dti-1336	78	70	inherited	inherited	ADJ
dti-1336	78	71	thrombophilic	thrombophilic	NOUN
dti-1336	78	72	abnormalities	abnormality	NOUN
dti-1336	78	73	.	.	PUNCT
dti-1336	79	1	combined	combine	VERB
dti-1336	79	2	genetic	genetic	ADJ
dti-1336	79	3	defects	defect	NOUN
dti-1336	79	4	as	as	ADV
dti-1336	79	5	well	well	ADV
dti-1336	79	6	as	as	ADP
dti-1336	79	7	the	the	DET
dti-1336	79	8	combination	combination	NOUN
dti-1336	79	9	of	of	ADP
dti-1336	79	10	a	a	DET
dti-1336	79	11	genetic	genetic	ADJ
dti-1336	79	12	defect	defect	NOUN
dti-1336	79	13	with	with	ADP
dti-1336	79	14	one	one	NUM
dti-1336	79	15	or	or	CCONJ
dti-1336	79	16	more	more	ADJ
dti-1336	79	17	acquired	acquire	VERB
dti-1336	79	18	risk	risk	NOUN
dti-1336	79	19	factors	factor	NOUN
dti-1336	79	20	and	and	CCONJ
dti-1336	79	21	the	the	DET
dti-1336	79	22	combination	combination	NOUN
dti-1336	79	23	of	of	ADP
dti-1336	79	24	92	92	NUM
dti-1336	79	25	zangari	zangari	NOUN
dti-1336	79	26	et	et	PROPN
dti-1336	79	27	al	al	PROPN
dti-1336	79	28	drug	drug	PROPN
dti-1336	79	29	target	target	NOUN
dti-1336	79	30	insights	insight	NOUN
dti-1336	79	31	2008:3	2008:3	NUM
dti-1336	79	32	two	two	NUM
dti-1336	79	33	acquired	acquire	VERB
dti-1336	79	34	risk	risk	NOUN
dti-1336	79	35	factors	factor	NOUN
dti-1336	79	36	result	result	VERB
dti-1336	79	37	in	in	ADP
dti-1336	79	38	a	a	DET
dti-1336	79	39	risk	risk	NOUN
dti-1336	79	40	of	of	ADP
dti-1336	79	41	vte	vte	NOUN
dti-1336	79	42	that	that	PRON
dti-1336	79	43	exceeds	exceed	VERB
dti-1336	79	44	the	the	DET
dti-1336	79	45	sum	sum	NOUN
dti-1336	79	46	of	of	ADP
dti-1336	79	47	single	single	ADJ
dti-1336	79	48	factors	factor	NOUN
dti-1336	79	49	effect	effect	VERB
dti-1336	79	50	.	.	PUNCT
dti-1336	80	1	pregnancy	pregnancy	NOUN
dti-1336	80	2	,	,	PUNCT
dti-1336	80	3	puerperium	puerperium	NOUN
dti-1336	80	4	,	,	PUNCT
dti-1336	80	5	oral	oral	ADJ
dti-1336	80	6	contraceptives	contraceptive	NOUN
dti-1336	80	7	and	and	CCONJ
dti-1336	80	8	hormone	hormone	NOUN
dti-1336	80	9	replacement	replacement	NOUN
dti-1336	80	10	therapy	therapy	NOUN
dti-1336	80	11	the	the	DET
dti-1336	80	12	risk	risk	NOUN
dti-1336	80	13	of	of	ADP
dti-1336	80	14	vte	vte	NOUN
dti-1336	80	15	is	be	AUX
dti-1336	80	16	approximately	approximately	ADV
dti-1336	80	17	10	10	NUM
dti-1336	80	18	-	-	ADJ
dti-1336	80	19	fold	fold	ADV
dti-1336	80	20	increased	increase	VERB
dti-1336	80	21	during	during	ADP
dti-1336	80	22	pregnancy	pregnancy	NOUN
dti-1336	80	23	and	and	CCONJ
dti-1336	80	24	puerperium	puerperium	NOUN
dti-1336	80	25	,	,	PUNCT
dti-1336	80	26	leading	lead	VERB
dti-1336	80	27	to	to	ADP
dti-1336	80	28	an	an	DET
dti-1336	80	29	overall	overall	ADJ
dti-1336	80	30	rate	rate	NOUN
dti-1336	80	31	of	of	ADP
dti-1336	80	32	vte	vte	NOUN
dti-1336	80	33	of	of	ADP
dti-1336	80	34	about	about	ADP
dti-1336	80	35	1%.37,38	1%.37,38	NUM
dti-1336	80	36	it	it	PRON
dti-1336	80	37	has	have	AUX
dti-1336	80	38	been	be	AUX
dti-1336	80	39	estimated	estimate	VERB
dti-1336	80	40	that	that	SCONJ
dti-1336	80	41	12	12	NUM
dti-1336	80	42	%	%	NOUN
dti-1336	80	43	of	of	ADP
dti-1336	80	44	the	the	DET
dti-1336	80	45	fatalities	fatality	NOUN
dti-1336	80	46	during	during	ADP
dti-1336	80	47	pregnancy	pregnancy	NOUN
dti-1336	80	48	are	be	AUX
dti-1336	80	49	attributable	attributable	ADJ
dti-1336	80	50	to	to	ADP
dti-1336	80	51	pulmonary	pulmonary	VERB
dti-1336	80	52	embolism;37,39	embolism;37,39	ADV
dti-1336	80	53	the	the	DET
dti-1336	80	54	presence	presence	NOUN
dti-1336	80	55	of	of	ADP
dti-1336	80	56	a	a	DET
dti-1336	80	57	hereditary	hereditary	ADJ
dti-1336	80	58	thrombophilia	thrombophilia	NOUN
dti-1336	80	59	represents	represent	VERB
dti-1336	80	60	a	a	DET
dti-1336	80	61	major	major	ADJ
dti-1336	80	62	risk	risk	NOUN
dti-1336	80	63	factor	factor	NOUN
dti-1336	80	64	in	in	ADP
dti-1336	80	65	this	this	DET
dti-1336	80	66	setting	setting	NOUN
dti-1336	80	67	.	.	PUNCT
dti-1336	81	1	thrombosis	thrombosis	NOUN
dti-1336	81	2	during	during	ADP
dti-1336	81	3	pregnancy	pregnancy	NOUN
dti-1336	81	4	and	and	CCONJ
dti-1336	81	5	puerperium	puerperium	NOUN
dti-1336	81	6	is	be	AUX
dti-1336	81	7	attributable	attributable	ADJ
dti-1336	81	8	both	both	CCONJ
dti-1336	81	9	to	to	ADP
dti-1336	81	10	venous	venous	ADJ
dti-1336	81	11	stasis	stasis	NOUN
dti-1336	81	12	(	(	PUNCT
dti-1336	81	13	caused	cause	VERB
dti-1336	81	14	by	by	ADP
dti-1336	81	15	the	the	DET
dti-1336	81	16	compression	compression	NOUN
dti-1336	81	17	from	from	ADP
dti-1336	81	18	the	the	DET
dti-1336	81	19	gravid	gravid	NOUN
dti-1336	81	20	uterus	uterus	NOUN
dti-1336	81	21	)	)	PUNCT
dti-1336	81	22	,	,	PUNCT
dti-1336	81	23	to	to	ADP
dti-1336	81	24	estrogen	estrogen	NOUN
dti-1336	81	25	-	-	PUNCT
dti-1336	81	26	dependent	dependent	ADJ
dti-1336	81	27	alterations	alteration	NOUN
dti-1336	81	28	of	of	ADP
dti-1336	81	29	the	the	DET
dti-1336	81	30	hemostatic	hemostatic	ADJ
dti-1336	81	31	mechanisms	mechanism	NOUN
dti-1336	81	32	like	like	ADP
dti-1336	81	33	elevation	elevation	NOUN
dti-1336	81	34	of	of	ADP
dti-1336	81	35	procoagulant	procoagulant	ADJ
dti-1336	81	36	factors	factor	NOUN
dti-1336	81	37	(	(	PUNCT
dti-1336	81	38	thrombin	thrombin	NOUN
dti-1336	81	39	,	,	PUNCT
dti-1336	81	40	tissue	tissue	NOUN
dti-1336	81	41	factor	factor	NOUN
dti-1336	81	42	,	,	PUNCT
dti-1336	81	43	fi	fi	NOUN
dti-1336	81	44	brinogen	brinogen	PROPN
dti-1336	81	45	,	,	PUNCT
dti-1336	81	46	factor	factor	NOUN
dti-1336	81	47	vii	vii	PROPN
dti-1336	81	48	,	,	PUNCT
dti-1336	81	49	ix	ix	PROPN
dti-1336	81	50	,	,	PUNCT
dti-1336	81	51	x	x	NOUN
dti-1336	81	52	,	,	PUNCT
dti-1336	81	53	xii	xii	PROPN
dti-1336	81	54	,	,	PUNCT
dti-1336	81	55	xiii	xiii	PRON
dti-1336	81	56	vwf	vwf	NOUN
dti-1336	81	57	)	)	PUNCT
dti-1336	81	58	,	,	PUNCT
dti-1336	81	59	to	to	ADP
dti-1336	81	60	the	the	DET
dti-1336	81	61	decline	decline	NOUN
dti-1336	81	62	of	of	ADP
dti-1336	81	63	the	the	DET
dti-1336	81	64	natural	natural	ADJ
dti-1336	81	65	anticoagulant	anticoagulant	ADJ
dti-1336	81	66	protein	protein	NOUN
dti-1336	81	67	s	s	NOUN
dti-1336	81	68	and	and	CCONJ
dti-1336	81	69	antithrombin40,41,42	antithrombin40,41,42	NOUN
dti-1336	81	70	and	and	CCONJ
dti-1336	81	71	to	to	ADP
dti-1336	81	72	impaired	impaired	ADJ
dti-1336	81	73	fi	fi	NOUN
dti-1336	81	74	brinolysis.43,44	brinolysis.43,44	VERB
dti-1336	81	75	the	the	DET
dti-1336	81	76	prothrombotic	prothrombotic	ADJ
dti-1336	81	77	effect	effect	NOUN
dti-1336	81	78	of	of	ADP
dti-1336	81	79	the	the	DET
dti-1336	81	80	estrogens	estrogen	NOUN
dti-1336	81	81	produces	produce	VERB
dti-1336	81	82	also	also	ADV
dti-1336	81	83	a	a	DET
dti-1336	81	84	2	2	NUM
dti-1336	81	85	-	-	PUNCT
dti-1336	81	86	to	to	ADP
dti-1336	81	87	5	5	NUM
dti-1336	81	88	-	-	ADJ
dti-1336	81	89	fold	fold	ADJ
dti-1336	81	90	increased	increased	ADJ
dti-1336	81	91	risk	risk	NOUN
dti-1336	81	92	of	of	ADP
dti-1336	81	93	venous	venous	ADJ
dti-1336	81	94	and	and	CCONJ
dti-1336	81	95	arterial	arterial	ADJ
dti-1336	81	96	thrombosis	thrombosis	NOUN
dti-1336	81	97	in	in	ADP
dti-1336	81	98	women	woman	NOUN
dti-1336	81	99	taking	take	VERB
dti-1336	81	100	oral	oral	ADJ
dti-1336	81	101	contraceptives.45	contraceptives.45	SCONJ
dti-1336	81	102	it	it	PRON
dti-1336	81	103	is	be	AUX
dti-1336	81	104	noteworthy	noteworthy	ADJ
dti-1336	81	105	that	that	SCONJ
dti-1336	81	106	incidence	incidence	NOUN
dti-1336	81	107	of	of	ADP
dti-1336	81	108	arterial	arterial	ADJ
dti-1336	81	109	thrombosis	thrombosis	NOUN
dti-1336	81	110	is	be	AUX
dti-1336	81	111	signifi	signifi	NOUN
dti-1336	81	112	ca	can	AUX
dti-1336	81	113	nt	not	PART
dti-1336	81	114	in	in	ADP
dti-1336	81	115	this	this	DET
dti-1336	81	116	setting	setting	NOUN
dti-1336	81	117	.	.	PUNCT
dti-1336	82	1	this	this	DET
dti-1336	82	2	risk	risk	NOUN
dti-1336	82	3	decreased	decrease	VERB
dti-1336	82	4	slightly	slightly	ADV
dti-1336	82	5	after	after	ADP
dti-1336	82	6	the	the	DET
dti-1336	82	7	reduction	reduction	NOUN
dti-1336	82	8	of	of	ADP
dti-1336	82	9	the	the	DET
dti-1336	82	10	estrogens	estrogen	NOUN
dti-1336	82	11	dose	dose	NOUN
dti-1336	82	12	content	content	NOUN
dti-1336	82	13	in	in	ADP
dti-1336	82	14	contraceptives	contraceptive	NOUN
dti-1336	82	15	(	(	PUNCT
dti-1336	82	16	from	from	ADP
dti-1336	82	17	fi	fi	NOUN
dti-1336	82	18	rst	rst	NOUN
dti-1336	82	19	to	to	PART
dti-1336	82	20	second	second	ADJ
dti-1336	82	21	generation	generation	NOUN
dti-1336	82	22	pills	pill	NOUN
dti-1336	82	23	)	)	PUNCT
dti-1336	82	24	,	,	PUNCT
dti-1336	82	25	but	but	CCONJ
dti-1336	82	26	further	further	ADJ
dti-1336	82	27	dose	dose	NOUN
dti-1336	82	28	reduction	reduction	NOUN
dti-1336	82	29	in	in	ADP
dti-1336	82	30	the	the	DET
dti-1336	82	31	latest	late	ADJ
dti-1336	82	32	contraceptives	contraceptive	NOUN
dti-1336	82	33	preparation	preparation	NOUN
dti-1336	82	34	did	do	AUX
dti-1336	82	35	not	not	PART
dti-1336	82	36	produce	produce	VERB
dti-1336	82	37	any	any	DET
dti-1336	82	38	additional	additional	ADJ
dti-1336	82	39	benefi	benefi	NOUN
dti-1336	82	40	t	t	PROPN
dti-1336	82	41	on	on	ADP
dti-1336	82	42	the	the	DET
dti-1336	82	43	thrombotic	thrombotic	ADJ
dti-1336	82	44	risk	risk	NOUN
dti-1336	82	45	.	.	PUNCT
dti-1336	83	1	many	many	ADJ
dti-1336	83	2	studies	study	NOUN
dti-1336	83	3	have	have	AUX
dti-1336	83	4	observed	observe	VERB
dti-1336	83	5	that	that	SCONJ
dti-1336	83	6	third	third	ADJ
dti-1336	83	7	-	-	PUNCT
dti-1336	83	8	generation	generation	NOUN
dti-1336	83	9	contraceptives	contraceptive	NOUN
dti-1336	83	10	containing	contain	VERB
dti-1336	83	11	the	the	DET
dti-1336	83	12	progestogens	progestogen	NOUN
dti-1336	83	13	desogestrel	desogestrel	NOUN
dti-1336	83	14	or	or	CCONJ
dti-1336	83	15	gestodene	gestodene	NOUN
dti-1336	83	16	carry	carry	VERB
dti-1336	83	17	a	a	DET
dti-1336	83	18	higher	high	ADJ
dti-1336	83	19	thrombotic	thrombotic	ADJ
dti-1336	83	20	risk	risk	NOUN
dti-1336	83	21	compared	compare	VERB
dti-1336	83	22	to	to	ADP
dti-1336	83	23	second	second	ADJ
dti-1336	83	24	generation	generation	NOUN
dti-1336	83	25	pills	pill	NOUN
dti-1336	83	26	containing	contain	VERB
dti-1336	83	27	levonorgestrel	levonorgestrel	NOUN
dti-1336	83	28	.	.	PUNCT
dti-1336	84	1	this	this	DET
dti-1336	84	2	difference	difference	NOUN
dti-1336	84	3	is	be	AUX
dti-1336	84	4	not	not	PART
dti-1336	84	5	due	due	ADJ
dti-1336	84	6	to	to	ADP
dti-1336	84	7	different	different	ADJ
dti-1336	84	8	estrogens	estrogen	NOUN
dti-1336	84	9	content	content	NOUN
dti-1336	84	10	but	but	CCONJ
dti-1336	84	11	presumably	presumably	ADV
dti-1336	84	12	by	by	ADP
dti-1336	84	13	the	the	DET
dti-1336	84	14	less	less	ADV
dti-1336	84	15	compensated	compensated	ADJ
dti-1336	84	16	effect	effect	NOUN
dti-1336	84	17	of	of	ADP
dti-1336	84	18	desogestrel	desogestrel	PROPN
dti-1336	84	19	compared	compare	VERB
dti-1336	84	20	to	to	ADP
dti-1336	84	21	levonorgestrel	levonorgestrel	NOUN
dti-1336	84	22	.	.	PUNCT
dti-1336	85	1	hormone	hormone	NOUN
dti-1336	85	2	replacement	replacement	NOUN
dti-1336	85	3	therapy	therapy	NOUN
dti-1336	85	4	,	,	PUNCT
dti-1336	85	5	which	which	PRON
dti-1336	85	6	often	often	ADV
dti-1336	85	7	consists	consist	VERB
dti-1336	85	8	in	in	ADP
dti-1336	85	9	a	a	DET
dti-1336	85	10	combination	combination	NOUN
dti-1336	85	11	of	of	ADP
dti-1336	85	12	conjugated	conjugate	VERB
dti-1336	85	13	estrogens	estrogen	NOUN
dti-1336	85	14	with	with	ADP
dti-1336	85	15	medroxyprogesterone	medroxyprogesterone	NOUN
dti-1336	85	16	,	,	PUNCT
dti-1336	85	17	is	be	AUX
dti-1336	85	18	associated	associate	VERB
dti-1336	85	19	with	with	ADP
dti-1336	85	20	a	a	DET
dti-1336	85	21	2to	2to	ADJ
dti-1336	85	22	4	4	NUM
dti-1336	85	23	-	-	ADJ
dti-1336	85	24	fold	fold	ADJ
dti-1336	85	25	higher	high	ADJ
dti-1336	85	26	risk	risk	NOUN
dti-1336	85	27	of	of	ADP
dti-1336	85	28	venous	venous	ADJ
dti-1336	85	29	and	and	CCONJ
dti-1336	85	30	arterial	arterial	NOUN
dti-1336	85	31	thrombosis.46,47	thrombosis.46,47	NOUN
dti-1336	85	32	for	for	ADP
dti-1336	85	33	either	either	CCONJ
dti-1336	85	34	oral	oral	ADJ
dti-1336	85	35	contraceptives	contraceptive	NOUN
dti-1336	85	36	or	or	CCONJ
dti-1336	85	37	hormone	hormone	NOUN
dti-1336	85	38	replacement	replacement	NOUN
dti-1336	85	39	therapy	therapy	NOUN
dti-1336	85	40	,	,	PUNCT
dti-1336	85	41	the	the	DET
dti-1336	85	42	risk	risk	NOUN
dti-1336	85	43	of	of	ADP
dti-1336	85	44	thrombosis	thrombosis	NOUN
dti-1336	85	45	is	be	AUX
dti-1336	85	46	highest	high	ADJ
dti-1336	85	47	shortly	shortly	ADV
dti-1336	85	48	after	after	ADP
dti-1336	85	49	the	the	DET
dti-1336	85	50	beginning	beginning	NOUN
dti-1336	85	51	of	of	ADP
dti-1336	85	52	therapy	therapy	NOUN
dti-1336	85	53	.	.	PUNCT
dti-1336	86	1	acquired	acquire	VERB
dti-1336	86	2	factors	factor	NOUN
dti-1336	86	3	like	like	ADP
dti-1336	86	4	obesity	obesity	NOUN
dti-1336	86	5	,	,	PUNCT
dti-1336	86	6	age	age	NOUN
dti-1336	86	7	,	,	PUNCT
dti-1336	86	8	and	and	CCONJ
dti-1336	86	9	the	the	DET
dti-1336	86	10	coexistence	coexistence	NOUN
dti-1336	86	11	of	of	ADP
dti-1336	86	12	hereditary	hereditary	ADJ
dti-1336	86	13	thrombophilic	thrombophilic	NOUN
dti-1336	86	14	disorder	disorder	NOUN
dti-1336	86	15	further	far	ADV
dti-1336	86	16	increase	increase	VERB
dti-1336	86	17	the	the	DET
dti-1336	86	18	thrombotic	thrombotic	ADJ
dti-1336	86	19	risk	risk	NOUN
dti-1336	86	20	.	.	PUNCT
dti-1336	87	1	in	in	ADP
dti-1336	87	2	particular	particular	ADJ
dti-1336	87	3	,	,	PUNCT
dti-1336	87	4	antithrombin	antithrombin	PROPN
dti-1336	87	5	,	,	PUNCT
dti-1336	87	6	protein	protein	NOUN
dti-1336	87	7	s	s	NOUN
dti-1336	87	8	or	or	CCONJ
dti-1336	87	9	c	c	NOUN
dti-1336	87	10	defi	defi	NOUN
dti-1336	87	11	ciency	ciency	NOUN
dti-1336	87	12	and	and	CCONJ
dti-1336	87	13	factor	factor	NOUN
dti-1336	87	14	v	v	PROPN
dti-1336	87	15	leiden	leiden	PROPN
dti-1336	87	16	greatly	greatly	ADV
dti-1336	87	17	enhance	enhance	VERB
dti-1336	87	18	this	this	DET
dti-1336	87	19	risk	risk	NOUN
dti-1336	87	20	:	:	PUNCT
dti-1336	87	21	women	woman	NOUN
dti-1336	87	22	with	with	ADP
dti-1336	87	23	factor	factor	NOUN
dti-1336	87	24	v	v	PROPN
dti-1336	87	25	leiden	leiden	PROPN
dti-1336	87	26	have	have	VERB
dti-1336	87	27	a	a	DET
dti-1336	87	28	15to	15to	ADJ
dti-1336	87	29	30	30	NUM
dti-1336	87	30	-	-	ADJ
dti-1336	87	31	fold	fold	ADJ
dti-1336	87	32	thrombotic	thrombotic	ADJ
dti-1336	87	33	risk	risk	NOUN
dti-1336	87	34	while	while	SCONJ
dti-1336	87	35	taking	take	VERB
dti-1336	87	36	oral	oral	ADJ
dti-1336	87	37	contraceptives.48,27	contraceptives.48,27	NOUN
dti-1336	87	38	cancer	cancer	NOUN
dti-1336	87	39	after	after	ADP
dti-1336	87	40	the	the	DET
dti-1336	87	41	fi	fi	NOUN
dti-1336	87	42	rst	rst	NOUN
dti-1336	87	43	report	report	NOUN
dti-1336	87	44	of	of	ADP
dti-1336	87	45	an	an	DET
dti-1336	87	46	association	association	NOUN
dti-1336	87	47	between	between	ADP
dti-1336	87	48	malignacies	malignacie	NOUN
dti-1336	87	49	and	and	CCONJ
dti-1336	87	50	thrombosis	thrombosis	NOUN
dti-1336	87	51	,	,	PUNCT
dti-1336	87	52	many	many	ADJ
dti-1336	87	53	large	large	ADJ
dti-1336	87	54	studies	study	NOUN
dti-1336	87	55	have	have	AUX
dti-1336	87	56	confi	confi	VERB
dti-1336	87	57	rmed	rme	VERB
dti-1336	87	58	the	the	DET
dti-1336	87	59	higher	high	ADJ
dti-1336	87	60	risk	risk	NOUN
dti-1336	87	61	of	of	ADP
dti-1336	87	62	thromboembolic	thromboembolic	ADJ
dti-1336	87	63	events	event	NOUN
dti-1336	87	64	in	in	ADP
dti-1336	87	65	the	the	DET
dti-1336	87	66	cancer	cancer	NOUN
dti-1336	87	67	population	population	NOUN
dti-1336	87	68	.	.	PUNCT
dti-1336	88	1	the	the	DET
dti-1336	88	2	rates	rate	NOUN
dti-1336	88	3	of	of	ADP
dti-1336	88	4	vte	vte	NOUN
dti-1336	88	5	in	in	ADP
dti-1336	88	6	cancer	cancer	NOUN
dti-1336	88	7	patients	patient	NOUN
dti-1336	88	8	have	have	VERB
dti-1336	88	9	a	a	DET
dti-1336	88	10	wide	wide	ADJ
dti-1336	88	11	variability	variability	NOUN
dti-1336	88	12	in	in	ADP
dti-1336	88	13	different	different	ADJ
dti-1336	88	14	trials	trial	NOUN
dti-1336	88	15	.	.	PUNCT
dti-1336	89	1	in	in	ADP
dti-1336	89	2	women	woman	NOUN
dti-1336	89	3	with	with	ADP
dti-1336	89	4	breast	breast	NOUN
dti-1336	89	5	cancer	cancer	NOUN
dti-1336	89	6	,	,	PUNCT
dti-1336	89	7	the	the	DET
dti-1336	89	8	vte	vte	NOUN
dti-1336	89	9	rate	rate	NOUN
dti-1336	89	10	ranges	range	VERB
dti-1336	89	11	from	from	ADP
dti-1336	89	12	0.1	0.1	NUM
dti-1336	89	13	%	%	NOUN
dti-1336	89	14	in	in	ADP
dti-1336	89	15	untreated	untreated	ADJ
dti-1336	89	16	stage	stage	NOUN
dti-1336	89	17	i	i	PRON
dti-1336	89	18	patients	patient	VERB
dti-1336	89	19	to	to	ADP
dti-1336	89	20	17	17	NUM
dti-1336	89	21	%	%	NOUN
dti-1336	89	22	in	in	ADP
dti-1336	89	23	chemotherapy	chemotherapy	NOUN
dti-1336	89	24	treated	treat	VERB
dti-1336	89	25	women	woman	NOUN
dti-1336	89	26	for	for	ADP
dti-1336	89	27	advanced	advanced	ADJ
dti-1336	89	28	stages	stage	NOUN
dti-1336	89	29	.	.	PUNCT
dti-1336	90	1	the	the	DET
dti-1336	90	2	mega	mega	ADJ
dti-1336	90	3	study	study	NOUN
dti-1336	90	4	accrued	accrue	VERB
dti-1336	90	5	3220	3220	NUM
dti-1336	90	6	unselected	unselected	ADJ
dti-1336	90	7	patients	patient	NOUN
dti-1336	90	8	with	with	ADP
dti-1336	90	9	vte	vte	NOUN
dti-1336	90	10	and	and	CCONJ
dti-1336	90	11	2131	2131	NUM
dti-1336	90	12	controls	control	NOUN
dti-1336	90	13	;	;	PUNCT
dti-1336	90	14	the	the	DET
dti-1336	90	15	presence	presence	NOUN
dti-1336	90	16	of	of	ADP
dti-1336	90	17	a	a	DET
dti-1336	90	18	malignancy	malignancy	NOUN
dti-1336	90	19	increased	increase	VERB
dti-1336	90	20	the	the	DET
dti-1336	90	21	thrombotic	thrombotic	ADJ
dti-1336	90	22	risk	risk	NOUN
dti-1336	90	23	4.3	4.3	NUM
dti-1336	90	24	fold.49	fold.49	NOUN
dti-1336	90	25	in	in	ADP
dti-1336	90	26	patients	patient	NOUN
dti-1336	90	27	with	with	ADP
dti-1336	90	28	cancer	cancer	NOUN
dti-1336	90	29	vte	vte	NOUN
dti-1336	90	30	represents	represent	VERB
dti-1336	90	31	an	an	DET
dti-1336	90	32	important	important	ADJ
dti-1336	90	33	case	case	NOUN
dti-1336	90	34	of	of	ADP
dti-1336	90	35	morbidity	morbidity	NOUN
dti-1336	90	36	and	and	CCONJ
dti-1336	90	37	mortality	mortality	NOUN
dti-1336	90	38	.	.	PUNCT
dti-1336	91	1	it	it	PRON
dti-1336	91	2	has	have	AUX
dti-1336	91	3	been	be	AUX
dti-1336	91	4	estimated	estimate	VERB
dti-1336	91	5	that	that	SCONJ
dti-1336	91	6	mortality	mortality	NOUN
dti-1336	91	7	in	in	ADP
dti-1336	91	8	one	one	NUM
dti-1336	91	9	of	of	ADP
dti-1336	91	10	every	every	DET
dti-1336	91	11	7	7	NUM
dti-1336	91	12	hospitalized	hospitalize	VERB
dti-1336	91	13	cancer	cancer	NOUN
dti-1336	91	14	patients	patient	NOUN
dti-1336	91	15	is	be	AUX
dti-1336	91	16	associated	associate	VERB
dti-1336	91	17	to	to	ADP
dti-1336	91	18	pulmonary	pulmonary	ADJ
dti-1336	91	19	embolism	embolism	NOUN
dti-1336	91	20	.	.	PUNCT
dti-1336	92	1	according	accord	VERB
dti-1336	92	2	to	to	ADP
dti-1336	92	3	“	"	PUNCT
dti-1336	92	4	medicare	medicare	VERB
dti-1336	92	5	provider	provider	NOUN
dti-1336	92	6	analysis	analysis	NOUN
dti-1336	92	7	and	and	CCONJ
dti-1336	92	8	review	review	NOUN
dti-1336	92	9	record	record	NOUN
dti-1336	92	10	”	"	PUNCT
dti-1336	92	11	,	,	PUNCT
dti-1336	92	12	the	the	DET
dti-1336	92	13	rate	rate	NOUN
dti-1336	92	14	of	of	ADP
dti-1336	92	15	initial	initial	ADJ
dti-1336	92	16	or	or	CCONJ
dti-1336	92	17	recurrent	recurrent	ADJ
dti-1336	92	18	thromboembolism	thromboembolism	NOUN
dti-1336	92	19	in	in	ADP
dti-1336	92	20	patients	patient	NOUN
dti-1336	92	21	with	with	ADP
dti-1336	92	22	cancer	cancer	NOUN
dti-1336	92	23	greatly	greatly	ADV
dti-1336	92	24	exceeds	exceed	VERB
dti-1336	92	25	the	the	DET
dti-1336	92	26	cardiovascular	cardiovascular	ADJ
dti-1336	92	27	complications	complication	NOUN
dti-1336	92	28	recorded	record	VERB
dti-1336	92	29	in	in	ADP
dti-1336	92	30	those	those	PRON
dti-1336	92	31	without	without	ADP
dti-1336	92	32	malignancy	malignancy	NOUN
dti-1336	92	33	,	,	PUNCT
dti-1336	92	34	and	and	CCONJ
dti-1336	92	35	occurs	occur	VERB
dti-1336	92	36	with	with	ADP
dti-1336	92	37	similar	similar	ADJ
dti-1336	92	38	frequency	frequency	NOUN
dti-1336	92	39	among	among	ADP
dti-1336	92	40	cancers	cancer	NOUN
dti-1336	92	41	of	of	ADP
dti-1336	92	42	virtually	virtually	ADV
dti-1336	92	43	all	all	DET
dti-1336	92	44	body	body	NOUN
dti-1336	92	45	systems	system	NOUN
dti-1336	92	46	.	.	PUNCT
dti-1336	93	1	the	the	DET
dti-1336	93	2	most	most	ADV
dti-1336	93	3	common	common	ADJ
dti-1336	93	4	co	co	NOUN
dti-1336	93	5	-	-	NOUN
dti-1336	93	6	morbidities	morbidity	NOUN
dti-1336	93	7	which	which	PRON
dti-1336	93	8	produce	produce	VERB
dti-1336	93	9	a	a	DET
dti-1336	93	10	higher	high	ADJ
dti-1336	93	11	risk	risk	NOUN
dti-1336	93	12	of	of	ADP
dti-1336	93	13	vte	vte	NOUN
dti-1336	93	14	in	in	ADP
dti-1336	93	15	cancer	cancer	NOUN
dti-1336	93	16	patients	patient	NOUN
dti-1336	93	17	include	include	VERB
dti-1336	93	18	immobilization	immobilization	NOUN
dti-1336	93	19	,	,	PUNCT
dti-1336	93	20	surgery	surgery	NOUN
dti-1336	93	21	,	,	PUNCT
dti-1336	93	22	chemotherapy	chemotherapy	NOUN
dti-1336	93	23	with	with	ADP
dti-1336	93	24	or	or	CCONJ
dti-1336	93	25	without	without	ADP
dti-1336	93	26	adjuvant	adjuvant	ADJ
dti-1336	93	27	hormone	hormone	NOUN
dti-1336	93	28	therapy	therapy	NOUN
dti-1336	93	29	,	,	PUNCT
dti-1336	93	30	and	and	CCONJ
dti-1336	93	31	the	the	DET
dti-1336	93	32	insertion	insertion	NOUN
dti-1336	93	33	of	of	ADP
dti-1336	93	34	central	central	ADJ
dti-1336	93	35	venous	venous	ADJ
dti-1336	93	36	catheters	catheter	NOUN
dti-1336	93	37	.	.	PUNCT
dti-1336	94	1	the	the	DET
dti-1336	94	2	relationship	relationship	NOUN
dti-1336	94	3	between	between	ADP
dti-1336	94	4	cancer	cancer	NOUN
dti-1336	94	5	and	and	CCONJ
dti-1336	94	6	venous	venous	ADJ
dti-1336	94	7	thromboembolism	thromboembolism	NOUN
dti-1336	94	8	is	be	AUX
dti-1336	94	9	further	far	ADV
dti-1336	94	10	emphasized	emphasize	VERB
dti-1336	94	11	by	by	ADP
dti-1336	94	12	the	the	DET
dti-1336	94	13	high	high	ADJ
dti-1336	94	14	rate	rate	NOUN
dti-1336	94	15	of	of	ADP
dti-1336	94	16	cancer	cancer	NOUN
dti-1336	94	17	development	development	NOUN
dti-1336	94	18	in	in	ADP
dti-1336	94	19	patients	patient	NOUN
dti-1336	94	20	with	with	ADP
dti-1336	94	21	unprovoked	unprovoked	ADJ
dti-1336	94	22	venous	venous	ADJ
dti-1336	94	23	thrombosis.50	thrombosis.50	PROPN
dti-1336	94	24	multiple	multiple	ADJ
dti-1336	94	25	studies	study	NOUN
dti-1336	94	26	have	have	AUX
dti-1336	94	27	consistently	consistently	ADV
dti-1336	94	28	shown	show	VERB
dti-1336	94	29	4–5	4–5	PROPN
dti-1336	94	30	times	time	NOUN
dti-1336	94	31	higher	high	ADJ
dti-1336	94	32	risk	risk	NOUN
dti-1336	94	33	in	in	ADP
dti-1336	94	34	patients	patient	NOUN
dti-1336	94	35	with	with	ADP
dti-1336	94	36	idiopathic	idiopathic	ADJ
dti-1336	94	37	rather	rather	ADV
dti-1336	94	38	than	than	ADP
dti-1336	94	39	in	in	ADP
dti-1336	94	40	subjects	subject	NOUN
dti-1336	94	41	with	with	ADP
dti-1336	94	42	secondary	secondary	ADJ
dti-1336	94	43	thrombosis	thrombosis	NOUN
dti-1336	94	44	.	.	PUNCT
dti-1336	95	1	three	three	NUM
dti-1336	95	2	largescale	largescale	NOUN
dti-1336	95	3	prevention	prevention	NOUN
dti-1336	95	4	studies	study	NOUN
dti-1336	95	5	involving	involve	VERB
dti-1336	95	6	over	over	ADP
dti-1336	95	7	5500	5500	NUM
dti-1336	95	8	medically	medically	ADV
dti-1336	95	9	ill	ill	ADJ
dti-1336	95	10	patients	patient	NOUN
dti-1336	95	11	have	have	AUX
dti-1336	95	12	shown	show	VERB
dti-1336	95	13	that	that	SCONJ
dti-1336	95	14	11%–15	11%–15	NUM
dti-1336	95	15	%	%	NOUN
dti-1336	95	16	will	will	AUX
dti-1336	95	17	have	have	VERB
dti-1336	95	18	vte	vte	NOUN
dti-1336	95	19	and	and	CCONJ
dti-1336	95	20	4%–5	4%–5	NUM
dti-1336	95	21	%	%	NOUN
dti-1336	95	22	will	will	AUX
dti-1336	95	23	have	have	VERB
dti-1336	95	24	proximal	proximal	ADJ
dti-1336	95	25	-	-	PUNCT
dti-1336	95	26	vein	vein	ADJ
dti-1336	95	27	thrombosis	thrombosis	NOUN
dti-1336	95	28	as	as	ADP
dti-1336	95	29	identifi	identifi	PROPN
dti-1336	95	30	ed	ed	NOUN
dti-1336	95	31	by	by	ADP
dti-1336	95	32	screening	screen	VERB
dti-1336	95	33	studies	study	NOUN
dti-1336	95	34	in	in	ADP
dti-1336	95	35	the	the	DET
dti-1336	95	36	absence	absence	NOUN
dti-1336	95	37	of	of	ADP
dti-1336	95	38	prophylaxis	prophylaxis	NOUN
dti-1336	95	39	.	.	PUNCT
dti-1336	96	1	carriers	carrier	NOUN
dti-1336	96	2	of	of	ADP
dti-1336	96	3	the	the	DET
dti-1336	96	4	factor	factor	NOUN
dti-1336	96	5	v	v	ADP
dti-1336	96	6	leiden	leiden	PROPN
dti-1336	96	7	mutation	mutation	NOUN
dti-1336	96	8	who	who	PRON
dti-1336	96	9	developed	develop	VERB
dti-1336	96	10	cancer	cancer	NOUN
dti-1336	96	11	had	have	VERB
dti-1336	96	12	a	a	DET
dti-1336	96	13	12fold	12fold	NUM
dti-1336	96	14	higher	high	ADJ
dti-1336	96	15	dvt	dvt	NOUN
dti-1336	96	16	risk	risk	NOUN
dti-1336	96	17	compared	compare	VERB
dti-1336	96	18	to	to	ADP
dti-1336	96	19	individuals	individual	NOUN
dti-1336	96	20	without	without	ADP
dti-1336	96	21	malignancy	malignancy	NOUN
dti-1336	96	22	and	and	CCONJ
dti-1336	96	23	factor	factor	NOUN
dti-1336	96	24	v	v	PROPN
dti-1336	96	25	leiden	leiden	PROPN
dti-1336	96	26	mutation	mutation	NOUN
dti-1336	96	27	;	;	PUNCT
dti-1336	96	28	similar	similar	ADJ
dti-1336	96	29	results	result	NOUN
dti-1336	96	30	were	be	AUX
dti-1336	96	31	observed	observe	VERB
dti-1336	96	32	in	in	ADP
dti-1336	96	33	carriers	carrier	NOUN
dti-1336	96	34	of	of	ADP
dti-1336	96	35	prothrombin	prothrombin	ADJ
dti-1336	96	36	gene	gene	NOUN
dti-1336	96	37	20210a	20210a	NOUN
dti-1336	96	38	variant	variant	NOUN
dti-1336	96	39	.	.	PUNCT
dti-1336	97	1	serine	serine	NOUN
dti-1336	97	2	proteases	protease	NOUN
dti-1336	97	3	such	such	ADJ
dti-1336	97	4	as	as	ADP
dti-1336	97	5	thrombin	thrombin	NOUN
dti-1336	97	6	and	and	CCONJ
dti-1336	97	7	tf	tf	NOUN
dti-1336	97	8	/	/	SYM
dti-1336	97	9	viia	viia	NOUN
dti-1336	97	10	operate	operate	VERB
dti-1336	97	11	not	not	PART
dti-1336	97	12	only	only	ADV
dti-1336	97	13	in	in	ADP
dti-1336	97	14	promoting	promote	VERB
dti-1336	97	15	clot	clot	NOUN
dti-1336	97	16	formation	formation	NOUN
dti-1336	97	17	but	but	CCONJ
dti-1336	97	18	93	93	NUM
dti-1336	97	19	thrombophilia	thrombophilia	NOUN
dti-1336	97	20	drug	drug	NOUN
dti-1336	97	21	target	target	NOUN
dti-1336	97	22	insights	insight	NOUN
dti-1336	97	23	2008:3	2008:3	NUM
dti-1336	97	24	function	function	NOUN
dti-1336	97	25	as	as	ADP
dti-1336	97	26	signaling	signal	VERB
dti-1336	97	27	factors	factor	NOUN
dti-1336	97	28	modulating	modulate	VERB
dti-1336	97	29	cellular	cellular	ADJ
dti-1336	97	30	behavior.51,52	behavior.51,52	ADJ
dti-1336	97	31	serine	serine	NOUN
dti-1336	97	32	proteases	protease	NOUN
dti-1336	97	33	communicate	communicate	VERB
dti-1336	97	34	with	with	ADP
dti-1336	97	35	cells	cell	NOUN
dti-1336	97	36	through	through	ADP
dti-1336	97	37	a	a	DET
dti-1336	97	38	family	family	NOUN
dti-1336	97	39	of	of	ADP
dti-1336	97	40	protease	protease	NOUN
dti-1336	97	41	activated	activate	VERB
dti-1336	97	42	receptors	receptor	NOUN
dti-1336	97	43	(	(	PUNCT
dti-1336	97	44	par1	par1	PROPN
dti-1336	97	45	,	,	PUNCT
dti-1336	97	46	par2	par2	PROPN
dti-1336	97	47	,	,	PUNCT
dti-1336	97	48	par3	par3	PROPN
dti-1336	97	49	,	,	PUNCT
dti-1336	97	50	par4	par4	PROPN
dti-1336	97	51	)	)	PUNCT
dti-1336	97	52	.	.	PUNCT
dti-1336	98	1	thrombin	thrombin	NOUN
dti-1336	98	2	can	can	AUX
dti-1336	98	3	activate	activate	VERB
dti-1336	98	4	par	par	NOUN
dti-1336	98	5	1	1	NUM
dti-1336	98	6	,	,	PUNCT
dti-1336	98	7	3	3	NUM
dti-1336	98	8	and	and	CCONJ
dti-1336	98	9	4	4	NUM
dti-1336	98	10	while	while	SCONJ
dti-1336	98	11	either	either	CCONJ
dti-1336	98	12	the	the	DET
dti-1336	98	13	tf	tf	ADJ
dti-1336	98	14	/	/	SYM
dti-1336	98	15	fviia	fviia	NOUN
dti-1336	98	16	or	or	CCONJ
dti-1336	98	17	the	the	DET
dti-1336	98	18	more	more	ADV
dti-1336	98	19	effective	effective	ADJ
dti-1336	98	20	tf	tf	ADJ
dti-1336	98	21	/	/	SYM
dti-1336	98	22	viia	viia	NOUN
dti-1336	98	23	/	/	SYM
dti-1336	98	24	xa	xa	PROPN
dti-1336	98	25	complex	complex	NOUN
dti-1336	98	26	activates	activate	VERB
dti-1336	98	27	par	par	NOUN
dti-1336	98	28	2	2	NUM
dti-1336	98	29	.	.	PUNCT
dti-1336	98	30	par	par	PROPN
dti-1336	98	31	is	be	AUX
dti-1336	98	32	expressed	express	VERB
dti-1336	98	33	primarily	primarily	ADV
dti-1336	98	34	by	by	ADP
dti-1336	98	35	cells	cell	NOUN
dti-1336	98	36	in	in	ADP
dti-1336	98	37	the	the	DET
dti-1336	98	38	vasculature	vasculature	NOUN
dti-1336	98	39	,	,	PUNCT
dti-1336	98	40	but	but	CCONJ
dti-1336	98	41	also	also	ADV
dti-1336	98	42	by	by	ADP
dti-1336	98	43	tumor	tumor	NOUN
dti-1336	98	44	cells	cell	NOUN
dti-1336	98	45	with	with	ADP
dti-1336	98	46	high	high	ADJ
dti-1336	98	47	metastatic	metastatic	ADJ
dti-1336	98	48	potential	potential	NOUN
dti-1336	98	49	.	.	PUNCT
dti-1336	99	1	thrombin	thrombin	NOUN
dti-1336	99	2	and	and	CCONJ
dti-1336	99	3	the	the	DET
dti-1336	99	4	tf/	tf/	ADV
dti-1336	99	5	fviia	fviia	ADJ
dti-1336	99	6	or	or	CCONJ
dti-1336	99	7	tf	tf	ADJ
dti-1336	99	8	/	/	SYM
dti-1336	99	9	fviia	fviia	NOUN
dti-1336	99	10	/	/	SYM
dti-1336	99	11	xa	xa	PROPN
dti-1336	99	12	complex	complex	PROPN
dti-1336	99	13	also	also	ADV
dti-1336	99	14	initiate	initiate	VERB
dti-1336	99	15	signal	signal	ADJ
dti-1336	99	16	transduction	transduction	NOUN
dti-1336	99	17	activating	activate	VERB
dti-1336	99	18	a	a	DET
dti-1336	99	19	number	number	NOUN
dti-1336	99	20	of	of	ADP
dti-1336	99	21	pathways	pathway	NOUN
dti-1336	99	22	that	that	PRON
dti-1336	99	23	shapes	shape	VERB
dti-1336	99	24	the	the	DET
dti-1336	99	25	microenvironment	microenvironment	NOUN
dti-1336	99	26	of	of	ADP
dti-1336	99	27	the	the	DET
dti-1336	99	28	tumor	tumor	NOUN
dti-1336	99	29	.	.	PUNCT
dti-1336	100	1	tf	tf	PROPN
dti-1336	100	2	has	have	AUX
dti-1336	100	3	been	be	AUX
dti-1336	100	4	found	find	VERB
dti-1336	100	5	a	a	DET
dti-1336	100	6	wide	wide	ADJ
dti-1336	100	7	variety	variety	NOUN
dti-1336	100	8	of	of	ADP
dti-1336	100	9	tumor	tumor	NOUN
dti-1336	100	10	cells.53,54	cells.53,54	NOUN
dti-1336	100	11	increasing	increase	VERB
dti-1336	100	12	expression	expression	NOUN
dti-1336	100	13	of	of	ADP
dti-1336	100	14	tf	tf	PROPN
dti-1336	100	15	correlates	correlate	VERB
dti-1336	100	16	with	with	ADP
dti-1336	100	17	advanced	advanced	ADJ
dti-1336	100	18	stages	stage	NOUN
dti-1336	100	19	of	of	ADP
dti-1336	100	20	disease	disease	NOUN
dti-1336	100	21	and	and	CCONJ
dti-1336	100	22	poorer	poor	ADJ
dti-1336	100	23	survival	survival	NOUN
dti-1336	100	24	rate.55,56	rate.55,56	VERB
dti-1336	100	25	the	the	DET
dti-1336	100	26	fi	fi	NOUN
dti-1336	100	27	brinolytic	brinolytic	ADJ
dti-1336	100	28	system	system	NOUN
dti-1336	100	29	functions	function	NOUN
dti-1336	100	30	either	either	CCONJ
dti-1336	100	31	within	within	ADP
dti-1336	100	32	the	the	DET
dti-1336	100	33	vascular	vascular	ADJ
dti-1336	100	34	space	space	NOUN
dti-1336	100	35	or	or	CCONJ
dti-1336	100	36	in	in	ADP
dti-1336	100	37	the	the	DET
dti-1336	100	38	tissue	tissue	NOUN
dti-1336	100	39	compartment	compartment	NOUN
dti-1336	100	40	.	.	PUNCT
dti-1336	101	1	plasminogen	plasminogen	NOUN
dti-1336	101	2	plays	play	VERB
dti-1336	101	3	a	a	DET
dti-1336	101	4	critical	critical	ADJ
dti-1336	101	5	role	role	NOUN
dti-1336	101	6	in	in	ADP
dti-1336	101	7	the	the	DET
dti-1336	101	8	extravascular	extravascular	ADJ
dti-1336	101	9	space	space	NOUN
dti-1336	101	10	serving	serve	VERB
dti-1336	101	11	as	as	ADP
dti-1336	101	12	the	the	DET
dti-1336	101	13	key	key	ADJ
dti-1336	101	14	mediator	mediator	NOUN
dti-1336	101	15	of	of	ADP
dti-1336	101	16	extracellular	extracellular	ADJ
dti-1336	101	17	proteolysis	proteolysis	NOUN
dti-1336	101	18	a	a	DET
dti-1336	101	19	process	process	NOUN
dti-1336	101	20	that	that	PRON
dti-1336	101	21	is	be	AUX
dti-1336	101	22	essential	essential	ADJ
dti-1336	101	23	for	for	ADP
dti-1336	101	24	cell	cell	NOUN
dti-1336	101	25	migration	migration	NOUN
dti-1336	101	26	.	.	PUNCT
dti-1336	102	1	plasmin	plasmin	ADJ
dti-1336	102	2	-	-	PUNCT
dti-1336	102	3	mediated	mediate	VERB
dti-1336	102	4	degradation	degradation	NOUN
dti-1336	102	5	of	of	ADP
dti-1336	102	6	extracellular	extracellular	ADJ
dti-1336	102	7	matrix	matrix	NOUN
dti-1336	102	8	enables	enable	VERB
dti-1336	102	9	malignant	malignant	ADJ
dti-1336	102	10	cells	cell	NOUN
dti-1336	102	11	to	to	PART
dti-1336	102	12	invade	invade	VERB
dti-1336	102	13	surrounding	surround	VERB
dti-1336	102	14	tissue	tissue	NOUN
dti-1336	102	15	and	and	CCONJ
dti-1336	102	16	also	also	ADV
dti-1336	102	17	facilitates	facilitate	VERB
dti-1336	102	18	a	a	DET
dti-1336	102	19	tumor	tumor	NOUN
dti-1336	102	20	’s	’s	PART
dti-1336	102	21	ability	ability	NOUN
dti-1336	102	22	to	to	PART
dti-1336	102	23	metastasize	metastasize	VERB
dti-1336	102	24	.	.	PUNCT
dti-1336	103	1	angiogenesis	angiogenesis	NOUN
dti-1336	103	2	is	be	AUX
dti-1336	103	3	also	also	ADV
dti-1336	103	4	dependent	dependent	ADJ
dti-1336	103	5	on	on	ADP
dti-1336	103	6	the	the	DET
dti-1336	103	7	tissue	tissue	NOUN
dti-1336	103	8	plasminogen	plasminogen	NOUN
dti-1336	103	9	system.57	system.57	PROPN
dti-1336	103	10	different	different	ADJ
dti-1336	103	11	model	model	NOUN
dti-1336	103	12	systems	system	NOUN
dti-1336	103	13	have	have	AUX
dti-1336	103	14	now	now	ADV
dti-1336	103	15	provide	provide	VERB
dti-1336	103	16	evidence	evidence	NOUN
dti-1336	103	17	that	that	SCONJ
dti-1336	103	18	oncogene	oncogene	NOUN
dti-1336	103	19	activation	activation	NOUN
dti-1336	103	20	or	or	CCONJ
dti-1336	103	21	tumor	tumor	NOUN
dti-1336	103	22	suppressor	suppressor	NOUN
dti-1336	103	23	gene	gene	NOUN
dti-1336	103	24	inactivation	inactivation	NOUN
dti-1336	103	25	upregulate	upregulate	VERB
dti-1336	103	26	clotting	clot	VERB
dti-1336	103	27	pathways	pathway	NOUN
dti-1336	103	28	in	in	ADP
dti-1336	103	29	vivo	vivo	NOUN
dti-1336	103	30	.	.	PUNCT
dti-1336	104	1	targeting	target	VERB
dti-1336	104	2	activated	activate	VERB
dti-1336	104	3	human	human	NOUN
dti-1336	104	4	met	meet	VERB
dti-1336	104	5	oncogene	oncogene	NOUN
dti-1336	104	6	to	to	PART
dti-1336	104	7	mouse	mouse	VERB
dti-1336	104	8	liver	liver	NOUN
dti-1336	104	9	with	with	ADP
dti-1336	104	10	a	a	DET
dti-1336	104	11	lentivrial	lentivrial	ADJ
dti-1336	104	12	vector	vector	NOUN
dti-1336	104	13	and	and	CCONJ
dti-1336	104	14	liver	liver	NOUN
dti-1336	104	15	-	-	PUNCT
dti-1336	104	16	specifi	specifi	PROPN
dti-1336	104	17	c	c	PROPN
dti-1336	104	18	promoter	promoter	NOUN
dti-1336	104	19	has	have	AUX
dti-1336	104	20	recently	recently	ADV
dti-1336	104	21	been	be	AUX
dti-1336	104	22	described	describe	VERB
dti-1336	104	23	as	as	ADP
dti-1336	104	24	a	a	DET
dti-1336	104	25	model	model	NOUN
dti-1336	104	26	for	for	ADP
dti-1336	104	27	human	human	ADJ
dti-1336	104	28	liver	liver	NOUN
dti-1336	104	29	carcinoma.58	carcinoma.58	PROPN
dti-1336	104	30	progressive	progressive	ADJ
dti-1336	104	31	hepatocarcinogenesis	hepatocarcinogenesis	NOUN
dti-1336	104	32	was	be	AUX
dti-1336	104	33	preceded	precede	VERB
dti-1336	104	34	and	and	CCONJ
dti-1336	104	35	accompanied	accompany	VERB
dti-1336	104	36	by	by	ADP
dti-1336	104	37	a	a	DET
dti-1336	104	38	thrombohemorrhagic	thrombohemorrhagic	NOUN
dti-1336	104	39	state	state	NOUN
dti-1336	104	40	,	,	PUNCT
dti-1336	104	41	which	which	PRON
dti-1336	104	42	was	be	AUX
dti-1336	104	43	indistinguishable	indistinguishable	ADJ
dti-1336	104	44	from	from	ADP
dti-1336	104	45	trousseau	trousseau	NOUN
dti-1336	104	46	’s	’s	PART
dti-1336	104	47	syndrome	syndrome	NOUN
dti-1336	104	48	with	with	ADP
dti-1336	104	49	disseminated	disseminate	VERB
dti-1336	104	50	intravascular	intravascular	ADJ
dti-1336	104	51	coagulation	coagulation	NOUN
dti-1336	104	52	(	(	PUNCT
dti-1336	104	53	dic).57	dic).57	VERB
dti-1336	104	54	the	the	DET
dti-1336	104	55	contribution	contribution	NOUN
dti-1336	104	56	of	of	ADP
dti-1336	104	57	platelet	platelet	NOUN
dti-1336	104	58	activation	activation	NOUN
dti-1336	104	59	to	to	ADP
dti-1336	104	60	tumor	tumor	NOUN
dti-1336	104	61	dissemination	dissemination	NOUN
dti-1336	104	62	has	have	AUX
dti-1336	104	63	been	be	AUX
dti-1336	104	64	recently	recently	ADV
dti-1336	104	65	elucidated	elucidate	VERB
dti-1336	104	66	;	;	PUNCT
dti-1336	104	67	palumbo	palumbo	NOUN
dti-1336	104	68	and	and	CCONJ
dti-1336	104	69	colleagues	colleague	NOUN
dti-1336	104	70	have	have	AUX
dti-1336	104	71	been	be	AUX
dti-1336	104	72	studied	study	VERB
dti-1336	104	73	mice	mouse	NOUN
dti-1336	104	74	lacking	lack	VERB
dti-1336	104	75	gαq	gαq	NOUN
dti-1336	104	76	,	,	PUNCT
dti-1336	104	77	a	a	DET
dti-1336	104	78	g	g	NOUN
dti-1336	104	79	protein	protein	NOUN
dti-1336	104	80	critical	critical	ADJ
dti-1336	104	81	for	for	ADP
dti-1336	104	82	platelet	platelet	NOUN
dti-1336	104	83	activation	activation	NOUN
dti-1336	104	84	.	.	PUNCT
dti-1336	105	1	loss	loss	NOUN
dti-1336	105	2	of	of	ADP
dti-1336	105	3	platelet	platelet	NOUN
dti-1336	105	4	activation	activation	NOUN
dti-1336	105	5	resulted	result	VERB
dti-1336	105	6	in	in	ADP
dti-1336	105	7	a	a	DET
dti-1336	105	8	profound	profound	ADJ
dti-1336	105	9	decrease	decrease	NOUN
dti-1336	105	10	in	in	ADP
dti-1336	105	11	both	both	CCONJ
dti-1336	105	12	experimental	experimental	ADJ
dti-1336	105	13	and	and	CCONJ
dti-1336	105	14	spontaneous	spontaneous	ADJ
dti-1336	105	15	metastases	metastasis	NOUN
dti-1336	105	16	after	after	ADP
dti-1336	105	17	injection	injection	NOUN
dti-1336	105	18	of	of	ADP
dti-1336	105	19	either	either	CCONJ
dti-1336	105	20	lewis	lewis	PROPN
dti-1336	105	21	lung	lung	PROPN
dti-1336	105	22	carcinoma	carcinoma	NOUN
dti-1336	105	23	cells	cell	NOUN
dti-1336	105	24	or	or	CCONJ
dti-1336	105	25	b16	b16	NOUN
dti-1336	105	26	melanoma	melanoma	NOUN
dti-1336	105	27	cells	cell	NOUN
dti-1336	105	28	.	.	PUNCT
dti-1336	106	1	radiolabeled	radiolabele	VERB
dti-1336	106	2	tumor	tumor	NOUN
dti-1336	106	3	cells	cell	NOUN
dti-1336	106	4	distribution	distribution	NOUN
dti-1336	106	5	demonstrated	demonstrate	VERB
dti-1336	106	6	that	that	SCONJ
dti-1336	106	7	diminished	diminish	VERB
dti-1336	106	8	platelet	platelet	NOUN
dti-1336	106	9	function	function	NOUN
dti-1336	106	10	and	and	CCONJ
dti-1336	106	11	decreased	decrease	VERB
dti-1336	106	12	fi	fi	NOUN
dti-1336	106	13	brinogen	brinogen	PROPN
dti-1336	106	14	,	,	PUNCT
dti-1336	106	15	signifi	signifi	PROPN
dti-1336	106	16	cantly	cantly	ADV
dti-1336	106	17	improved	improve	VERB
dti-1336	106	18	the	the	DET
dti-1336	106	19	survival	survival	NOUN
dti-1336	106	20	of	of	ADP
dti-1336	106	21	circulation	circulation	NOUN
dti-1336	106	22	tumor	tumor	NOUN
dti-1336	106	23	cells	cell	NOUN
dti-1336	106	24	in	in	ADP
dti-1336	106	25	the	the	DET
dti-1336	106	26	pulmonary	pulmonary	ADJ
dti-1336	106	27	vasculature	vasculature	NOUN
dti-1336	106	28	.	.	PUNCT
dti-1336	107	1	the	the	DET
dti-1336	107	2	prometastatic	prometastatic	ADJ
dti-1336	107	3	effect	effect	NOUN
dti-1336	107	4	conferred	confer	VERB
dti-1336	107	5	by	by	ADP
dti-1336	107	6	either	either	DET
dti-1336	107	7	platelets	platelet	NOUN
dti-1336	107	8	or	or	CCONJ
dti-1336	107	9	fi	fi	NOUN
dti-1336	107	10	brinogen	brinogen	PROPN
dti-1336	107	11	was	be	AUX
dti-1336	107	12	linked	link	VERB
dti-1336	107	13	to	to	ADP
dti-1336	107	14	a	a	DET
dti-1336	107	15	reduction	reduction	NOUN
dti-1336	107	16	in	in	ADP
dti-1336	107	17	natural	natural	ADJ
dti-1336	107	18	killer	killer	NOUN
dti-1336	107	19	cell	cell	NOUN
dti-1336	107	20	function.59	function.59	NOUN
dti-1336	107	21	medically	medically	ADV
dti-1336	107	22	ill	ill	ADJ
dti-1336	107	23	patients	patient	NOUN
dti-1336	107	24	the	the	DET
dti-1336	107	25	frequency	frequency	NOUN
dti-1336	107	26	of	of	ADP
dti-1336	107	27	dvt	dvt	PROPN
dti-1336	107	28	in	in	ADP
dti-1336	107	29	medically	medically	ADV
dti-1336	107	30	ill	ill	ADJ
dti-1336	107	31	patients	patient	NOUN
dti-1336	107	32	,	,	PUNCT
dti-1336	107	33	in	in	ADP
dti-1336	107	34	the	the	DET
dti-1336	107	35	absence	absence	NOUN
dti-1336	107	36	of	of	ADP
dti-1336	107	37	prophylaxis	prophylaxis	NOUN
dti-1336	107	38	,	,	PUNCT
dti-1336	107	39	varies	vary	VERB
dti-1336	107	40	from	from	ADP
dti-1336	107	41	10	10	NUM
dti-1336	107	42	%	%	NOUN
dti-1336	107	43	to	to	PART
dti-1336	107	44	26	26	NUM
dti-1336	107	45	%	%	NOUN
dti-1336	107	46	.	.	PUNCT
dti-1336	108	1	about	about	ADV
dti-1336	108	2	10	10	NUM
dti-1336	108	3	%	%	NOUN
dti-1336	108	4	of	of	ADP
dti-1336	108	5	deaths	death	NOUN
dti-1336	108	6	that	that	PRON
dti-1336	108	7	occur	occur	VERB
dti-1336	108	8	in	in	ADP
dti-1336	108	9	hospitals	hospital	NOUN
dti-1336	108	10	are	be	AUX
dti-1336	108	11	associated	associate	VERB
dti-1336	108	12	to	to	ADP
dti-1336	108	13	pulmonary	pulmonary	ADJ
dti-1336	108	14	embolism	embolism	NOUN
dti-1336	108	15	and	and	CCONJ
dti-1336	108	16	75	75	NUM
dti-1336	108	17	%	%	NOUN
dti-1336	108	18	of	of	ADP
dti-1336	108	19	fatal	fatal	ADJ
dti-1336	108	20	pulmonary	pulmonary	NOUN
dti-1336	108	21	emboli	emboli	PRON
dti-1336	108	22	develop	develop	VERB
dti-1336	108	23	in	in	ADP
dti-1336	108	24	medical	medical	ADJ
dti-1336	108	25	population	population	NOUN
dti-1336	108	26	.	.	PUNCT
dti-1336	109	1	numerous	numerous	ADJ
dti-1336	109	2	risk	risk	NOUN
dti-1336	109	3	factors	factor	NOUN
dti-1336	109	4	for	for	ADP
dti-1336	109	5	vte	vte	NOUN
dti-1336	109	6	have	have	AUX
dti-1336	109	7	been	be	AUX
dti-1336	109	8	identifi	identifi	PROPN
dti-1336	109	9	ed	ed	NOUN
dti-1336	109	10	.	.	PUNCT
dti-1336	110	1	these	these	DET
dti-1336	110	2	clinical	clinical	ADJ
dti-1336	110	3	risk	risk	NOUN
dti-1336	110	4	factors	factor	NOUN
dti-1336	110	5	include	include	VERB
dti-1336	110	6	increasing	increase	VERB
dti-1336	110	7	age	age	NOUN
dti-1336	110	8	,	,	PUNCT
dti-1336	110	9	heart	heart	NOUN
dti-1336	110	10	and	and	CCONJ
dti-1336	110	11	respiratory	respiratory	ADJ
dti-1336	110	12	failure	failure	NOUN
dti-1336	110	13	,	,	PUNCT
dti-1336	110	14	prolonged	prolonged	ADJ
dti-1336	110	15	immobility	immobility	NOUN
dti-1336	110	16	,	,	PUNCT
dti-1336	110	17	stroke	stroke	NOUN
dti-1336	110	18	or	or	CCONJ
dti-1336	110	19	paralysis	paralysis	NOUN
dti-1336	110	20	,	,	PUNCT
dti-1336	110	21	previous	previous	ADJ
dti-1336	110	22	vte	vte	NOUN
dti-1336	110	23	,	,	PUNCT
dti-1336	110	24	cancer	cancer	NOUN
dti-1336	110	25	chemotherapy	chemotherapy	NOUN
dti-1336	110	26	and	and	CCONJ
dti-1336	110	27	,	,	PUNCT
dti-1336	110	28	acute	acute	ADJ
dti-1336	110	29	infection	infection	NOUN
dti-1336	110	30	,	,	PUNCT
dti-1336	110	31	dehydration	dehydration	NOUN
dti-1336	110	32	,	,	PUNCT
dti-1336	110	33	hormonal	hormonal	ADJ
dti-1336	110	34	treatment	treatment	NOUN
dti-1336	110	35	,	,	PUNCT
dti-1336	110	36	varicose	varicose	NOUN
dti-1336	110	37	veins	vein	NOUN
dti-1336	110	38	;	;	PUNCT
dti-1336	110	39	incidence	incidence	NOUN
dti-1336	110	40	of	of	ADP
dti-1336	110	41	dvt	dvt	PROPN
dti-1336	110	42	has	have	AUX
dti-1336	110	43	been	be	AUX
dti-1336	110	44	also	also	ADV
dti-1336	110	45	noted	note	VERB
dti-1336	110	46	to	to	PART
dti-1336	110	47	rise	rise	VERB
dti-1336	110	48	in	in	ADP
dti-1336	110	49	association	association	NOUN
dti-1336	110	50	with	with	ADP
dti-1336	110	51	acute	acute	PROPN
dti-1336	110	52	infl	infl	PROPN
dti-1336	110	53	ammatory	ammatory	PROPN
dti-1336	110	54	bowel	bowel	NOUN
dti-1336	110	55	disease	disease	NOUN
dti-1336	110	56	,	,	PUNCT
dti-1336	110	57	rheumatologic	rheumatologic	NOUN
dti-1336	110	58	disease	disease	NOUN
dti-1336	110	59	,	,	PUNCT
dti-1336	110	60	and	and	CCONJ
dti-1336	110	61	nephrotic	nephrotic	ADJ
dti-1336	110	62	syndrome	syndrome	NOUN
dti-1336	110	63	.	.	PUNCT
dti-1336	111	1	patient	patient	ADJ
dti-1336	111	2	carriers	carrier	NOUN
dti-1336	111	3	of	of	ADP
dti-1336	111	4	proximalvein	proximalvein	NOUN
dti-1336	111	5	thrombosis	thrombosis	NOUN
dti-1336	111	6	have	have	VERB
dti-1336	111	7	an	an	DET
dti-1336	111	8	unexpectedly	unexpectedly	ADV
dti-1336	111	9	high	high	ADJ
dti-1336	111	10	risk	risk	NOUN
dti-1336	111	11	of	of	ADP
dti-1336	111	12	in	in	ADP
dti-1336	111	13	-	-	PUNCT
dti-1336	111	14	hospital	hospital	NOUN
dti-1336	111	15	death	death	NOUN
dti-1336	111	16	.	.	PUNCT
dti-1336	112	1	risks	risk	NOUN
dti-1336	112	2	factors	factor	NOUN
dti-1336	112	3	for	for	ADP
dti-1336	112	4	vte	vte	NOUN
dti-1336	112	5	in	in	ADP
dti-1336	112	6	medically	medically	ADV
dti-1336	112	7	ill	ill	ADJ
dti-1336	112	8	patients	patient	NOUN
dti-1336	112	9	have	have	VERB
dti-1336	112	10	a	a	DET
dti-1336	112	11	cumulative	cumulative	ADJ
dti-1336	112	12	effect	effect	NOUN
dti-1336	112	13	;	;	PUNCT
dti-1336	112	14	hospitalized	hospitalize	VERB
dti-1336	112	15	subjects	subject	NOUN
dti-1336	112	16	with	with	ADP
dti-1336	112	17	thrombophilia	thrombophilia	NOUN
dti-1336	112	18	or	or	CCONJ
dti-1336	112	19	a	a	DET
dti-1336	112	20	history	history	NOUN
dti-1336	112	21	of	of	ADP
dti-1336	112	22	thrombosis	thrombosis	NOUN
dti-1336	112	23	are	be	AUX
dti-1336	112	24	at	at	ADP
dti-1336	112	25	increased	increase	VERB
dti-1336	112	26	risk	risk	NOUN
dti-1336	112	27	of	of	ADP
dti-1336	112	28	vte	vte	NOUN
dti-1336	112	29	,	,	PUNCT
dti-1336	112	30	as	as	ADV
dti-1336	112	31	well	well	ADV
dti-1336	112	32	as	as	ADP
dti-1336	112	33	patients	patient	NOUN
dti-1336	112	34	with	with	ADP
dti-1336	112	35	lower	low	ADJ
dti-1336	112	36	limb	limb	NOUN
dti-1336	112	37	paralysis	paralysis	NOUN
dti-1336	112	38	from	from	ADP
dti-1336	112	39	acute	acute	ADJ
dti-1336	112	40	ischaemic	ischaemic	ADJ
dti-1336	112	41	stroke	stroke	NOUN
dti-1336	112	42	.	.	PUNCT
dti-1336	113	1	acquired	acquire	VERB
dti-1336	113	2	activated	activated	ADJ
dti-1336	113	3	protein	protein	NOUN
dti-1336	113	4	c	c	NOUN
dti-1336	113	5	(	(	PUNCT
dti-1336	113	6	apc	apc	PROPN
dti-1336	113	7	)	)	PUNCT
dti-1336	113	8	resistance	resistance	NOUN
dti-1336	113	9	abnormally	abnormally	ADV
dti-1336	113	10	increased	increase	VERB
dti-1336	113	11	resistance	resistance	NOUN
dti-1336	113	12	to	to	ADP
dti-1336	113	13	apc	apc	PROPN
dti-1336	113	14	has	have	AUX
dti-1336	113	15	been	be	AUX
dti-1336	113	16	observed	observe	VERB
dti-1336	113	17	in	in	ADP
dti-1336	113	18	patients	patient	NOUN
dti-1336	113	19	not	not	PART
dti-1336	113	20	carrying	carry	VERB
dti-1336	113	21	factor	factor	NOUN
dti-1336	113	22	v	v	PROPN
dti-1336	113	23	leiden	leiden	PROPN
dti-1336	113	24	mutation	mutation	NOUN
dti-1336	113	25	;	;	PUNCT
dti-1336	113	26	this	this	DET
dti-1336	113	27	phenomenon	phenomenon	NOUN
dti-1336	113	28	has	have	AUX
dti-1336	113	29	been	be	AUX
dti-1336	113	30	defi	defi	NOUN
dti-1336	113	31	ned	ne	VERB
dti-1336	113	32	as	as	SCONJ
dti-1336	113	33	acquired	acquire	VERB
dti-1336	113	34	apc	apc	PROPN
dti-1336	113	35	resistance	resistance	NOUN
dti-1336	113	36	.	.	PUNCT
dti-1336	114	1	in	in	ADP
dti-1336	114	2	a	a	DET
dti-1336	114	3	large	large	ADJ
dti-1336	114	4	cohort	cohort	NOUN
dti-1336	114	5	of	of	ADP
dti-1336	114	6	15,109	15,109	NUM
dti-1336	114	7	unselected	unselected	ADJ
dti-1336	114	8	subjects	subject	NOUN
dti-1336	114	9	,	,	PUNCT
dti-1336	114	10	2.3	2.3	NUM
dti-1336	114	11	%	%	NOUN
dti-1336	114	12	showed	show	VERB
dti-1336	114	13	an	an	DET
dti-1336	114	14	apc	apc	PROPN
dti-1336	114	15	resistance	resistance	NOUN
dti-1336	114	16	in	in	ADP
dti-1336	114	17	the	the	DET
dti-1336	114	18	absence	absence	NOUN
dti-1336	114	19	of	of	ADP
dti-1336	114	20	factor	factor	NOUN
dti-1336	114	21	v	v	PROPN
dti-1336	114	22	mutation.60	mutation.60	PROPN
dti-1336	114	23	the	the	DET
dti-1336	114	24	presence	presence	NOUN
dti-1336	114	25	of	of	ADP
dti-1336	114	26	an	an	DET
dti-1336	114	27	apc	apc	PROPN
dti-1336	114	28	resistance	resistance	NOUN
dti-1336	114	29	increases	increase	VERB
dti-1336	114	30	the	the	DET
dti-1336	114	31	thrombotic	thrombotic	ADJ
dti-1336	114	32	risk	risk	NOUN
dti-1336	114	33	,	,	PUNCT
dti-1336	114	34	independently	independently	ADV
dti-1336	114	35	from	from	ADP
dti-1336	114	36	presence	presence	NOUN
dti-1336	114	37	of	of	ADP
dti-1336	114	38	a	a	DET
dti-1336	114	39	genetic	genetic	ADJ
dti-1336	114	40	defect.61,62	defect.61,62	NOUN
dti-1336	114	41	resistance	resistance	NOUN
dti-1336	114	42	to	to	ADP
dti-1336	114	43	apc	apc	PROPN
dti-1336	114	44	has	have	AUX
dti-1336	114	45	been	be	AUX
dti-1336	114	46	also	also	ADV
dti-1336	114	47	described	describe	VERB
dti-1336	114	48	with	with	ADP
dti-1336	114	49	cerebrovascular	cerebrovascular	ADJ
dti-1336	114	50	diseases	disease	NOUN
dti-1336	114	51	and	and	CCONJ
dti-1336	114	52	preeclampsia.63,64	preeclampsia.63,64	VERB
dti-1336	114	53	many	many	ADJ
dti-1336	114	54	physiologic	physiologic	ADJ
dti-1336	114	55	and	and	CCONJ
dti-1336	114	56	pathologic	pathologic	ADJ
dti-1336	114	57	conditions	condition	NOUN
dti-1336	114	58	have	have	AUX
dti-1336	114	59	been	be	AUX
dti-1336	114	60	associated	associate	VERB
dti-1336	114	61	with	with	ADP
dti-1336	114	62	the	the	DET
dti-1336	114	63	presence	presence	NOUN
dti-1336	114	64	of	of	ADP
dti-1336	114	65	acquired	acquire	VERB
dti-1336	114	66	apc	apc	PROPN
dti-1336	114	67	resistance:65	resistance:65	PROPN
dti-1336	114	68	pregnancy	pregnancy	NOUN
dti-1336	114	69	,	,	PUNCT
dti-1336	114	70	oral	oral	ADJ
dti-1336	114	71	contraceptives	contraceptive	NOUN
dti-1336	114	72	and	and	CCONJ
dti-1336	114	73	hormone	hormone	NOUN
dti-1336	114	74	replacement	replacement	NOUN
dti-1336	114	75	therapy	therapy	NOUN
dti-1336	114	76	,	,	PUNCT
dti-1336	114	77	lupus	lupus	NOUN
dti-1336	114	78	anticoagulant	anticoagulant	NOUN
dti-1336	114	79	syndrome	syndrome	NOUN
dti-1336	114	80	,	,	PUNCT
dti-1336	114	81	and	and	CCONJ
dti-1336	114	82	neoplasia	neoplasia	NOUN
dti-1336	114	83	.	.	PUNCT
dti-1336	115	1	several	several	ADJ
dti-1336	115	2	authors	author	NOUN
dti-1336	115	3	have	have	AUX
dti-1336	115	4	recently	recently	ADV
dti-1336	115	5	described	describe	VERB
dti-1336	115	6	the	the	DET
dti-1336	115	7	presence	presence	NOUN
dti-1336	115	8	of	of	ADP
dti-1336	115	9	apc	apc	PROPN
dti-1336	115	10	resistance	resistance	NOUN
dti-1336	115	11	in	in	ADP
dti-1336	115	12	patients	patient	NOUN
dti-1336	115	13	with	with	ADP
dti-1336	115	14	malignancies	malignancy	NOUN
dti-1336	115	15	;	;	PUNCT
dti-1336	115	16	in	in	ADP
dti-1336	115	17	addition	addition	NOUN
dti-1336	115	18	,	,	PUNCT
dti-1336	115	19	multiple	multiple	ADJ
dti-1336	115	20	reports	report	NOUN
dti-1336	115	21	indicated	indicate	VERB
dti-1336	115	22	an	an	DET
dti-1336	115	23	association	association	NOUN
dti-1336	115	24	between	between	ADP
dti-1336	115	25	low	low	ADJ
dti-1336	115	26	apc	apc	PROPN
dti-1336	115	27	levels	level	NOUN
dti-1336	115	28	and	and	CCONJ
dti-1336	115	29	increased	increase	VERB
dti-1336	115	30	thrombotic	thrombotic	ADJ
dti-1336	115	31	risk	risk	NOUN
dti-1336	115	32	in	in	ADP
dti-1336	115	33	cancer.66,67,68	cancer.66,67,68	NOUN
dti-1336	115	34	testing	testing	NOUN
dti-1336	115	35	cancer	cancer	NOUN
dti-1336	115	36	patients	patient	NOUN
dti-1336	115	37	for	for	ADP
dti-1336	115	38	baseline	baseline	PROPN
dti-1336	115	39	apc	apc	PROPN
dti-1336	115	40	resistance	resistance	PROPN
dti-1336	115	41	seems	seem	VERB
dti-1336	115	42	to	to	PART
dti-1336	115	43	be	be	AUX
dti-1336	115	44	an	an	DET
dti-1336	115	45	appealing	appealing	ADJ
dti-1336	115	46	screening	screening	NOUN
dti-1336	115	47	method	method	NOUN
dti-1336	115	48	to	to	PART
dti-1336	115	49	identify	identify	VERB
dti-1336	115	50	hypercoagulable	hypercoagulable	ADJ
dti-1336	115	51	subjects	subject	NOUN
dti-1336	115	52	with	with	ADP
dti-1336	115	53	impaired	impaired	ADJ
dti-1336	115	54	natural	natural	ADJ
dti-1336	115	55	anticoagulant	anticoagulant	ADJ
dti-1336	115	56	system	system	NOUN
dti-1336	115	57	.	.	PUNCT
dti-1336	116	1	however	however	ADV
dti-1336	116	2	,	,	PUNCT
dti-1336	116	3	the	the	DET
dti-1336	116	4	initiation	initiation	NOUN
dti-1336	116	5	of	of	ADP
dti-1336	116	6	an	an	DET
dti-1336	116	7	anticoagulant	anticoagulant	NOUN
dti-1336	116	8	therapy	therapy	NOUN
dti-1336	116	9	or	or	CCONJ
dti-1336	116	10	94	94	NUM
dti-1336	116	11	zangari	zangari	PROPN
dti-1336	116	12	et	et	PROPN
dti-1336	116	13	al	al	PROPN
dti-1336	116	14	drug	drug	PROPN
dti-1336	116	15	target	target	NOUN
dti-1336	116	16	insights	insight	NOUN
dti-1336	116	17	2008:3	2008:3	NUM
dti-1336	116	18	prophylaxis	prophylaxis	NOUN
dti-1336	116	19	based	base	VERB
dti-1336	116	20	only	only	ADV
dti-1336	116	21	on	on	ADP
dti-1336	116	22	the	the	DET
dti-1336	116	23	presence	presence	NOUN
dti-1336	116	24	of	of	ADP
dti-1336	116	25	apc	apc	PROPN
dti-1336	116	26	resistance	resistance	NOUN
dti-1336	116	27	is	be	AUX
dti-1336	116	28	not	not	PART
dti-1336	116	29	fully	fully	ADV
dti-1336	116	30	justifi	justifi	NOUN
dti-1336	116	31	ed	ed	NOUN
dti-1336	116	32	by	by	ADP
dti-1336	116	33	current	current	ADJ
dti-1336	116	34	data	datum	NOUN
dti-1336	116	35	.	.	PUNCT
dti-1336	117	1	antiphospholipid	antiphospholipid	PROPN
dti-1336	117	2	antibodies	antibodie	VERB
dti-1336	117	3	antiphospholipid	antiphospholipid	NOUN
dti-1336	117	4	antibodies	antibody	NOUN
dti-1336	117	5	are	be	AUX
dti-1336	117	6	a	a	DET
dti-1336	117	7	heterogenous	heterogenous	ADJ
dti-1336	117	8	group	group	NOUN
dti-1336	117	9	of	of	ADP
dti-1336	117	10	autoantibodies	autoantibody	NOUN
dti-1336	117	11	directed	direct	VERB
dti-1336	117	12	against	against	ADP
dti-1336	117	13	anionic	anionic	ADJ
dti-1336	117	14	phospholipids	phospholipid	NOUN
dti-1336	117	15	.	.	PUNCT
dti-1336	118	1	there	there	PRON
dti-1336	118	2	are	be	VERB
dti-1336	118	3	two	two	NUM
dti-1336	118	4	classes	class	NOUN
dti-1336	118	5	of	of	ADP
dti-1336	118	6	antiphospholipid	antiphospholipid	NOUN
dti-1336	118	7	antibodies	antibody	NOUN
dti-1336	118	8	:	:	PUNCT
dti-1336	118	9	anticardiolipin	anticardiolipin	NOUN
dti-1336	118	10	antibodies	antibodie	VERB
dti-1336	118	11	and	and	CCONJ
dti-1336	118	12	lupus	lupus	ADJ
dti-1336	118	13	anticoagulants	anticoagulant	NOUN
dti-1336	118	14	.	.	PUNCT
dti-1336	119	1	anticardiolipin	anticardiolipin	PROPN
dti-1336	119	2	antibodies	antibodie	VERB
dti-1336	119	3	,	,	PUNCT
dti-1336	119	4	which	which	PRON
dti-1336	119	5	can	can	AUX
dti-1336	119	6	be	be	AUX
dti-1336	119	7	igg	igg	PROPN
dti-1336	119	8	or	or	CCONJ
dti-1336	119	9	,	,	PUNCT
dti-1336	119	10	less	less	ADV
dti-1336	119	11	often	often	ADV
dti-1336	119	12	,	,	PUNCT
dti-1336	119	13	igm	igm	PROPN
dti-1336	119	14	,	,	PUNCT
dti-1336	119	15	may	may	AUX
dti-1336	119	16	be	be	AUX
dti-1336	119	17	directed	direct	VERB
dti-1336	119	18	against	against	ADP
dti-1336	119	19	β2	β2	NOUN
dti-1336	119	20	-	-	PUNCT
dti-1336	119	21	glycoprotein	glycoprotein	NOUN
dti-1336	119	22	1	1	NUM
dti-1336	119	23	and	and	CCONJ
dti-1336	119	24	quantifi	quantifi	PROPN
dti-1336	119	25	ed	ed	NOUN
dti-1336	119	26	by	by	ADP
dti-1336	119	27	elisa	elisa	NOUN
dti-1336	119	28	that	that	PRON
dti-1336	119	29	uses	use	VERB
dti-1336	119	30	cardiolipin	cardiolipin	NOUN
dti-1336	119	31	as	as	SCONJ
dti-1336	119	32	the	the	DET
dti-1336	119	33	antigen.69	antigen.69	NOUN
dti-1336	119	34	high	high	ADJ
dti-1336	119	35	-	-	PUNCT
dti-1336	119	36	titer	titer	NOUN
dti-1336	119	37	igg	igg	PROPN
dti-1336	119	38	anticardiolipin	anticardiolipin	PROPN
dti-1336	119	39	antibodies	antibody	NOUN
dti-1336	119	40	are	be	AUX
dti-1336	119	41	most	most	ADV
dti-1336	119	42	strongly	strongly	ADV
dti-1336	119	43	associated	associate	VERB
dti-1336	119	44	with	with	ADP
dti-1336	119	45	clinical	clinical	ADJ
dti-1336	119	46	manifestations	manifestation	NOUN
dti-1336	119	47	.	.	PUNCT
dti-1336	120	1	lupus	lupus	ADJ
dti-1336	120	2	anticoagulants	anticoagulant	NOUN
dti-1336	120	3	are	be	AUX
dti-1336	120	4	very	very	ADV
dti-1336	120	5	common	common	ADJ
dti-1336	120	6	in	in	ADP
dti-1336	120	7	normal	normal	ADJ
dti-1336	120	8	children	child	NOUN
dti-1336	120	9	and	and	CCONJ
dti-1336	120	10	are	be	AUX
dti-1336	120	11	frequently	frequently	ADV
dti-1336	120	12	identifi	identifi	ADJ
dti-1336	120	13	ed	ed	NOUN
dti-1336	120	14	prior	prior	ADV
dti-1336	120	15	to	to	ADP
dti-1336	120	16	scheduled	scheduled	ADJ
dti-1336	120	17	tonsillectomy	tonsillectomy	NOUN
dti-1336	120	18	/	/	SYM
dti-1336	120	19	adenoidectomy	adenoidectomy	NOUN
dti-1336	120	20	or	or	CCONJ
dti-1336	120	21	the	the	DET
dti-1336	120	22	basis	basis	NOUN
dti-1336	120	23	of	of	ADP
dti-1336	120	24	a	a	DET
dti-1336	120	25	prolonged	prolonged	ADJ
dti-1336	120	26	aptt	aptt	NOUN
dti-1336	120	27	.	.	PUNCT
dti-1336	121	1	in	in	ADP
dti-1336	121	2	this	this	DET
dti-1336	121	3	setting	setting	NOUN
dti-1336	121	4	,	,	PUNCT
dti-1336	121	5	they	they	PRON
dti-1336	121	6	are	be	AUX
dti-1336	121	7	not	not	PART
dti-1336	121	8	a	a	DET
dti-1336	121	9	signifi	signifi	NOUN
dti-1336	121	10	ca	can	AUX
dti-1336	121	11	nt	not	PART
dti-1336	121	12	risk	risk	VERB
dti-1336	121	13	factor	factor	NOUN
dti-1336	121	14	for	for	ADP
dti-1336	121	15	thrombosis	thrombosis	NOUN
dti-1336	121	16	.	.	PUNCT
dti-1336	122	1	lupus	lupus	ADJ
dti-1336	122	2	anticoagulants	anticoagulant	NOUN
dti-1336	122	3	induce	induce	VERB
dti-1336	122	4	a	a	DET
dti-1336	122	5	dose	dose	ADJ
dti-1336	122	6	dependent	dependent	ADJ
dti-1336	122	7	prolongation	prolongation	NOUN
dti-1336	122	8	in	in	ADP
dti-1336	122	9	phospholipiddependent	phospholipiddependent	NOUN
dti-1336	122	10	clotting	clot	VERB
dti-1336	122	11	assays	assay	NOUN
dti-1336	122	12	such	such	ADJ
dti-1336	122	13	as	as	ADP
dti-1336	122	14	the	the	DET
dti-1336	122	15	aptt	aptt	NOUN
dti-1336	122	16	using	use	VERB
dti-1336	122	17	a	a	DET
dti-1336	122	18	sensitive	sensitive	ADJ
dti-1336	122	19	reagent	reagent	NOUN
dti-1336	122	20	,	,	PUNCT
dti-1336	122	21	the	the	DET
dti-1336	122	22	dilute	dilute	PROPN
dti-1336	122	23	pt	pt	PROPN
dti-1336	122	24	,	,	PUNCT
dti-1336	122	25	russell	russell	PROPN
dti-1336	122	26	viper	viper	NOUN
dti-1336	122	27	venom	venom	NOUN
dti-1336	122	28	time	time	NOUN
dti-1336	122	29	or	or	CCONJ
dti-1336	122	30	kaolin	kaolin	NOUN
dti-1336	122	31	clotting	clotting	NOUN
dti-1336	122	32	time	time	NOUN
dti-1336	122	33	.	.	PUNCT
dti-1336	123	1	the	the	DET
dti-1336	123	2	presence	presence	NOUN
dti-1336	123	3	of	of	ADP
dti-1336	123	4	such	such	ADJ
dti-1336	123	5	antibodies	antibody	NOUN
dti-1336	123	6	can	can	AUX
dti-1336	123	7	be	be	AUX
dti-1336	123	8	indicated	indicate	VERB
dti-1336	123	9	by	by	ADP
dti-1336	123	10	the	the	DET
dti-1336	123	11	failure	failure	NOUN
dti-1336	123	12	of	of	ADP
dti-1336	123	13	aptt	aptt	NOUN
dti-1336	123	14	to	to	PART
dti-1336	123	15	correct	correct	VERB
dti-1336	123	16	when	when	SCONJ
dti-1336	123	17	normal	normal	ADJ
dti-1336	123	18	plasma	plasma	NOUN
dti-1336	123	19	is	be	AUX
dti-1336	123	20	added	add	VERB
dti-1336	123	21	in	in	ADP
dti-1336	123	22	mixing	mix	VERB
dti-1336	123	23	studies	study	NOUN
dti-1336	123	24	.	.	PUNCT
dti-1336	124	1	the	the	DET
dti-1336	124	2	mechanism	mechanism	NOUN
dti-1336	124	3	by	by	ADP
dti-1336	124	4	which	which	PRON
dti-1336	124	5	antiphospholipid	antiphospholipid	NOUN
dti-1336	124	6	antibodies	antibody	NOUN
dti-1336	124	7	cause	cause	VERB
dti-1336	124	8	thrombosis	thrombosis	NOUN
dti-1336	124	9	is	be	AUX
dti-1336	124	10	unclear	unclear	ADJ
dti-1336	124	11	.	.	PUNCT
dti-1336	125	1	there	there	PRON
dti-1336	125	2	is	be	VERB
dti-1336	125	3	evidence	evidence	NOUN
dti-1336	125	4	that	that	SCONJ
dti-1336	125	5	the	the	DET
dti-1336	125	6	antibodies	antibody	NOUN
dti-1336	125	7	interfere	interfere	VERB
dti-1336	125	8	with	with	ADP
dti-1336	125	9	the	the	DET
dti-1336	125	10	protein	protein	NOUN
dti-1336	125	11	c	c	NOUN
dti-1336	125	12	pathway	pathway	NOUN
dti-1336	125	13	by	by	ADP
dti-1336	125	14	impairing	impair	VERB
dti-1336	125	15	both	both	PRON
dti-1336	125	16	protein	protein	NOUN
dti-1336	125	17	c	c	NOUN
dti-1336	125	18	activation	activation	NOUN
dti-1336	125	19	and	and	CCONJ
dti-1336	125	20	the	the	DET
dti-1336	125	21	function	function	NOUN
dti-1336	125	22	of	of	ADP
dti-1336	125	23	apc	apc	PROPN
dti-1336	125	24	.	.	PUNCT
dti-1336	126	1	endothelial	endothelial	ADJ
dti-1336	126	2	cell	cell	NOUN
dti-1336	126	3	dysfunction	dysfunction	NOUN
dti-1336	126	4	with	with	ADP
dti-1336	126	5	reduced	reduce	VERB
dti-1336	126	6	prostacyclin	prostacyclin	ADJ
dti-1336	126	7	synthesis	synthesis	NOUN
dti-1336	126	8	and	and	CCONJ
dti-1336	126	9	antibody	antibody	NOUN
dti-1336	126	10	-	-	PUNCT
dti-1336	126	11	induce	induce	VERB
dti-1336	126	12	platelet	platelet	NOUN
dti-1336	126	13	activation	activation	NOUN
dti-1336	126	14	have	have	AUX
dti-1336	126	15	also	also	ADV
dti-1336	126	16	been	be	AUX
dti-1336	126	17	described	describe	VERB
dti-1336	126	18	.	.	PUNCT
dti-1336	127	1	the	the	DET
dti-1336	127	2	antiphospholipid	antiphospholipid	NOUN
dti-1336	127	3	antibody	antibody	NOUN
dti-1336	127	4	syndrome	syndrome	NOUN
dti-1336	127	5	is	be	AUX
dti-1336	127	6	defi	defi	NOUN
dti-1336	127	7	ned	ne	VERB
dti-1336	127	8	by	by	ADP
dti-1336	127	9	thrombosis	thrombosis	NOUN
dti-1336	127	10	or	or	CCONJ
dti-1336	127	11	pregnancy	pregnancy	NOUN
dti-1336	127	12	morbidity	morbidity	NOUN
dti-1336	127	13	in	in	ADP
dti-1336	127	14	association	association	NOUN
dti-1336	127	15	with	with	ADP
dti-1336	127	16	a	a	DET
dti-1336	127	17	persistent	persistent	ADJ
dti-1336	127	18	elevation	elevation	NOUN
dti-1336	127	19	(	(	PUNCT
dti-1336	127	20	�	�	NOUN
dti-1336	127	21	12	12	NUM
dti-1336	127	22	weeks	week	NOUN
dti-1336	127	23	)	)	PUNCT
dti-1336	127	24	of	of	ADP
dti-1336	127	25	lupus	lupus	ADJ
dti-1336	127	26	anticoagulant	anticoagulant	NOUN
dti-1336	127	27	,	,	PUNCT
dti-1336	127	28	anticardiolipin	anticardiolipin	NOUN
dti-1336	127	29	,	,	PUNCT
dti-1336	127	30	or	or	CCONJ
dti-1336	127	31	antiβ2	antiβ2	ADJ
dti-1336	127	32	glycoprotein	glycoprotein	NOUN
dti-1336	127	33	i	i	PRON
dti-1336	127	34	antibodies.69	antibodies.69	VERB
dti-1336	127	35	clinical	clinical	ADJ
dti-1336	127	36	manifestations	manifestation	NOUN
dti-1336	127	37	are	be	AUX
dti-1336	127	38	venous	venous	ADJ
dti-1336	127	39	or	or	CCONJ
dti-1336	127	40	arterial	arterial	ADJ
dti-1336	127	41	thrombosis	thrombosis	NOUN
dti-1336	127	42	,	,	PUNCT
dti-1336	127	43	recurrent	recurrent	ADJ
dti-1336	127	44	fetal	fetal	ADJ
dti-1336	127	45	loss	loss	NOUN
dti-1336	127	46	,	,	PUNCT
dti-1336	127	47	and	and	CCONJ
dti-1336	127	48	livedo	livedo	PROPN
dti-1336	127	49	reticularis	reticularis	PROPN
dti-1336	127	50	.	.	PUNCT
dti-1336	128	1	the	the	DET
dti-1336	128	2	clinical	clinical	ADJ
dti-1336	128	3	signifi	signifi	NOUN
dti-1336	128	4	cance	cance	NOUN
dti-1336	128	5	of	of	ADP
dti-1336	128	6	transient	transient	ADJ
dti-1336	128	7	antiphospholipid	antiphospholipid	NOUN
dti-1336	128	8	antibodies	antibody	NOUN
dti-1336	128	9	is	be	AUX
dti-1336	128	10	unclear	unclear	ADJ
dti-1336	128	11	and	and	CCONJ
dti-1336	128	12	testing	testing	NOUN
dti-1336	128	13	should	should	AUX
dti-1336	128	14	be	be	AUX
dti-1336	128	15	repeated	repeat	VERB
dti-1336	128	16	at	at	ADP
dti-1336	128	17	6–12	6–12	NOUN
dti-1336	128	18	weeks	week	NOUN
dti-1336	128	19	.	.	PUNCT
dti-1336	129	1	although	although	SCONJ
dti-1336	129	2	antiphospholipid	antiphospholipid	NOUN
dti-1336	129	3	antibody	antibody	NOUN
dti-1336	129	4	syndrome	syndrome	NOUN
dti-1336	129	5	can	can	AUX
dti-1336	129	6	be	be	AUX
dti-1336	129	7	idiopathic	idiopathic	ADJ
dti-1336	129	8	,	,	PUNCT
dti-1336	129	9	it	it	PRON
dti-1336	129	10	is	be	AUX
dti-1336	129	11	frequently	frequently	ADV
dti-1336	129	12	associated	associate	VERB
dti-1336	129	13	to	to	ADP
dti-1336	129	14	systemic	systemic	ADJ
dti-1336	129	15	lupus	lupus	PROPN
dti-1336	129	16	erythematosus	erythematosus	PROPN
dti-1336	129	17	,	,	PUNCT
dti-1336	129	18	or	or	CCONJ
dti-1336	129	19	cancer	cancer	NOUN
dti-1336	129	20	(	(	PUNCT
dti-1336	129	21	such	such	ADJ
dti-1336	129	22	as	as	ADP
dti-1336	129	23	lymphoma	lymphoma	NOUN
dti-1336	129	24	)	)	PUNCT
dti-1336	129	25	or	or	CCONJ
dti-1336	129	26	infections	infection	NOUN
dti-1336	129	27	(	(	PUNCT
dti-1336	129	28	pneumocystis	pneumocystis	NOUN
dti-1336	129	29	carinii	carinii	ADJ
dti-1336	129	30	pneumonia	pneumonia	NOUN
dti-1336	129	31	,	,	PUNCT
dti-1336	129	32	in	in	ADP
dti-1336	129	33	hiv	hiv	PROPN
dti-1336	129	34	patients	patient	NOUN
dti-1336	129	35	)	)	PUNCT
dti-1336	129	36	,	,	PUNCT
dti-1336	129	37	and	and	CCONJ
dti-1336	129	38	in	in	ADP
dti-1336	129	39	association	association	NOUN
dti-1336	129	40	with	with	ADP
dti-1336	129	41	drugs	drug	NOUN
dti-1336	129	42	such	such	ADJ
dti-1336	129	43	as	as	ADP
dti-1336	129	44	hydralazine	hydralazine	NOUN
dti-1336	129	45	or	or	CCONJ
dti-1336	129	46	procainamide	procainamide	NOUN
dti-1336	129	47	.	.	PUNCT
dti-1336	130	1	all	all	DET
dti-1336	130	2	patients	patient	NOUN
dti-1336	130	3	�	�	VERB
dti-1336	130	4	65	65	NUM
dti-1336	130	5	years	year	NOUN
dti-1336	130	6	of	of	ADP
dti-1336	130	7	age	age	NOUN
dti-1336	130	8	who	who	PRON
dti-1336	130	9	present	present	VERB
dti-1336	130	10	with	with	ADP
dti-1336	130	11	transient	transient	ADJ
dti-1336	130	12	ischemic	ischemic	ADJ
dti-1336	130	13	attacks	attack	NOUN
dti-1336	130	14	or	or	CCONJ
dti-1336	130	15	ischemic	ischemic	ADJ
dti-1336	130	16	stroke	stroke	NOUN
dti-1336	130	17	should	should	AUX
dti-1336	130	18	be	be	AUX
dti-1336	130	19	screened	screen	VERB
dti-1336	130	20	for	for	ADP
dti-1336	130	21	antiphospholipid	antiphospholipid	NOUN
dti-1336	130	22	antibodies	antibody	NOUN
dti-1336	130	23	.	.	PUNCT
dti-1336	131	1	management	management	NOUN
dti-1336	131	2	of	of	ADP
dti-1336	131	3	thrombotic	thrombotic	ADJ
dti-1336	131	4	defects	defect	NOUN
dti-1336	131	5	asymptomatic	asymptomatic	ADJ
dti-1336	131	6	patients	patient	NOUN
dti-1336	131	7	with	with	ADP
dti-1336	131	8	hereditary	hereditary	ADJ
dti-1336	131	9	thrombophilia	thrombophilia	NOUN
dti-1336	131	10	identifi	identifi	PROPN
dti-1336	131	11	ed	ed	NOUN
dti-1336	131	12	through	through	ADP
dti-1336	131	13	family	family	NOUN
dti-1336	131	14	studies	study	NOUN
dti-1336	131	15	should	should	AUX
dti-1336	131	16	not	not	PART
dti-1336	131	17	receive	receive	VERB
dti-1336	131	18	long	long	ADJ
dti-1336	131	19	-	-	PUNCT
dti-1336	131	20	term	term	NOUN
dti-1336	131	21	oral	oral	ADJ
dti-1336	131	22	anticoagulation	anticoagulation	NOUN
dti-1336	131	23	.	.	PUNCT
dti-1336	132	1	they	they	PRON
dti-1336	132	2	should	should	AUX
dti-1336	132	3	,	,	PUNCT
dti-1336	132	4	however	however	ADV
dti-1336	132	5	,	,	PUNCT
dti-1336	132	6	receive	receive	VERB
dti-1336	132	7	counselling	counselling	NOUN
dti-1336	132	8	regarding	regard	VERB
dti-1336	132	9	their	their	PRON
dti-1336	132	10	diagnosis	diagnosis	NOUN
dti-1336	132	11	and	and	CCONJ
dti-1336	132	12	need	need	VERB
dti-1336	132	13	for	for	ADP
dti-1336	132	14	prophylaxis	prophylaxis	NOUN
dti-1336	132	15	during	during	ADP
dti-1336	132	16	high	high	ADJ
dti-1336	132	17	-	-	PUNCT
dti-1336	132	18	risk	risk	NOUN
dti-1336	132	19	periods.70	periods.70	NOUN
dti-1336	132	20	in	in	ADP
dti-1336	132	21	patients	patient	NOUN
dti-1336	132	22	who	who	PRON
dti-1336	132	23	have	have	VERB
dti-1336	132	24	a	a	DET
dti-1336	132	25	fi	fi	NOUN
dti-1336	132	26	rst	rst	PROPN
dti-1336	132	27	venous	venous	ADJ
dti-1336	132	28	thrombotic	thrombotic	ADJ
dti-1336	132	29	even	even	ADV
dti-1336	132	30	in	in	ADP
dti-1336	132	31	the	the	DET
dti-1336	132	32	setting	setting	NOUN
dti-1336	132	33	of	of	ADP
dti-1336	132	34	a	a	DET
dti-1336	132	35	transient	transient	ADJ
dti-1336	132	36	triggering	trigger	VERB
dti-1336	132	37	factor	factor	NOUN
dti-1336	132	38	,	,	PUNCT
dti-1336	132	39	anticoagulation	anticoagulation	NOUN
dti-1336	132	40	can	can	AUX
dti-1336	132	41	be	be	AUX
dti-1336	132	42	discontinued	discontinue	VERB
dti-1336	132	43	after	after	ADP
dti-1336	132	44	3	3	NUM
dti-1336	132	45	to	to	PART
dti-1336	132	46	6	6	NUM
dti-1336	132	47	months	month	NOUN
dti-1336	132	48	after	after	ADP
dti-1336	132	49	removal	removal	NOUN
dti-1336	132	50	of	of	ADP
dti-1336	132	51	the	the	DET
dti-1336	132	52	triggering	trigger	VERB
dti-1336	132	53	factor	factor	NOUN
dti-1336	132	54	.	.	PUNCT
dti-1336	133	1	patients	patient	NOUN
dti-1336	133	2	with	with	ADP
dti-1336	133	3	idiopathic	idiopathic	ADJ
dti-1336	133	4	thromboembolism	thromboembolism	NOUN
dti-1336	133	5	without	without	ADP
dti-1336	133	6	triggering	trigger	VERB
dti-1336	133	7	factors	factor	NOUN
dti-1336	133	8	are	be	AUX
dti-1336	133	9	generally	generally	ADV
dti-1336	133	10	treated	treat	VERB
dti-1336	133	11	for	for	ADP
dti-1336	133	12	6	6	NUM
dti-1336	133	13	months	month	NOUN
dti-1336	133	14	.	.	PUNCT
dti-1336	134	1	extended	extend	VERB
dti-1336	134	2	anticoagulation	anticoagulation	NOUN
dti-1336	134	3	should	should	AUX
dti-1336	134	4	be	be	AUX
dti-1336	134	5	considered	consider	VERB
dti-1336	134	6	for	for	ADP
dti-1336	134	7	single	single	ADJ
dti-1336	134	8	unprovoked	unprovoked	ADJ
dti-1336	134	9	venous	venous	ADJ
dti-1336	134	10	thrombotic	thrombotic	ADJ
dti-1336	134	11	events	event	NOUN
dti-1336	134	12	in	in	ADP
dti-1336	134	13	the	the	DET
dti-1336	134	14	presence	presence	NOUN
dti-1336	134	15	of	of	ADP
dti-1336	134	16	more	more	ADJ
dti-1336	134	17	than	than	ADP
dti-1336	134	18	one	one	NUM
dti-1336	134	19	allelic	allelic	ADJ
dti-1336	134	20	abnormality	abnormality	NOUN
dti-1336	134	21	(	(	PUNCT
dti-1336	134	22	for	for	ADP
dti-1336	134	23	example	example	NOUN
dti-1336	134	24	,	,	PUNCT
dti-1336	134	25	homozygous	homozygous	ADJ
dti-1336	134	26	factor	factor	NOUN
dti-1336	134	27	v	v	NOUN
dti-1336	134	28	leiden	leiden	PROPN
dti-1336	134	29	and	and	CCONJ
dti-1336	134	30	combined	combined	ADJ
dti-1336	134	31	heterozygosity	heterozygosity	NOUN
dti-1336	134	32	for	for	ADP
dti-1336	134	33	factor	factor	NOUN
dti-1336	134	34	v	v	ADP
dti-1336	134	35	leiden	leiden	PROPN
dti-1336	134	36	and	and	CCONJ
dti-1336	134	37	prothrombin	prothrombin	VERB
dti-1336	134	38	g20210a	g20210a	PROPN
dti-1336	134	39	mutation	mutation	NOUN
dti-1336	134	40	)	)	PUNCT
dti-1336	134	41	,	,	PUNCT
dti-1336	134	42	and	and	CCONJ
dti-1336	134	43	initial	initial	ADJ
dti-1336	134	44	life	life	NOUN
dti-1336	134	45	-	-	PUNCT
dti-1336	134	46	threatening	threaten	VERB
dti-1336	134	47	thrombosis	thrombosis	NOUN
dti-1336	134	48	(	(	PUNCT
dti-1336	134	49	such	such	ADJ
dti-1336	134	50	as	as	ADP
dti-1336	134	51	massive	massive	ADJ
dti-1336	134	52	pulmonary	pulmonary	ADJ
dti-1336	134	53	embolism	embolism	NOUN
dti-1336	134	54	or	or	CCONJ
dti-1336	134	55	cerebral	cerebral	ADJ
dti-1336	134	56	,	,	PUNCT
dti-1336	134	57	mesenteric	mesenteric	ADJ
dti-1336	134	58	,	,	PUNCT
dti-1336	134	59	portal	portal	ADJ
dti-1336	134	60	,	,	PUNCT
dti-1336	134	61	or	or	CCONJ
dti-1336	134	62	hepatic	hepatic	ADJ
dti-1336	134	63	venous	venous	ADJ
dti-1336	134	64	thrombosis	thrombosis	NOUN
dti-1336	134	65	)	)	PUNCT
dti-1336	134	66	,	,	PUNCT
dti-1336	134	67	after	after	ADP
dti-1336	134	68	second	second	ADJ
dti-1336	134	69	unprovoked	unprovoked	ADJ
dti-1336	134	70	thrombotic	thrombotic	ADJ
dti-1336	134	71	episode	episode	NOUN
dti-1336	134	72	.	.	PUNCT
dti-1336	135	1	in	in	ADP
dti-1336	135	2	the	the	DET
dti-1336	135	3	setting	setting	NOUN
dti-1336	135	4	of	of	ADP
dti-1336	135	5	acute	acute	ADJ
dti-1336	135	6	thrombosis	thrombosis	NOUN
dti-1336	135	7	,	,	PUNCT
dti-1336	135	8	the	the	DET
dti-1336	135	9	presence	presence	NOUN
dti-1336	135	10	of	of	ADP
dti-1336	135	11	factor	factor	NOUN
dti-1336	135	12	v	v	PROPN
dti-1336	135	13	leiden	leiden	NOUN
dti-1336	135	14	of	of	ADP
dti-1336	135	15	prothrombin	prothrombin	NOUN
dti-1336	135	16	g20210a	g20210a	PROPN
dti-1336	135	17	does	do	AUX
dti-1336	135	18	not	not	PART
dti-1336	135	19	alter	alter	VERB
dti-1336	135	20	the	the	DET
dti-1336	135	21	initial	initial	ADJ
dti-1336	135	22	anticoagulation	anticoagulation	NOUN
dti-1336	135	23	regimen	regiman	NOUN
dti-1336	135	24	.	.	PUNCT
dti-1336	136	1	patients	patient	NOUN
dti-1336	136	2	with	with	ADP
dti-1336	136	3	a	a	DET
dti-1336	136	4	diagnosis	diagnosis	NOUN
dti-1336	136	5	of	of	ADP
dti-1336	136	6	one	one	NUM
dti-1336	136	7	of	of	ADP
dti-1336	136	8	the	the	DET
dti-1336	136	9	less	less	ADV
dti-1336	136	10	common	common	ADJ
dti-1336	136	11	thrombophilias	thrombophilia	NOUN
dti-1336	136	12	(	(	PUNCT
dti-1336	136	13	defi	defi	PROPN
dti-1336	136	14	ciencies	ciencie	NOUN
dti-1336	136	15	of	of	ADP
dti-1336	136	16	antithrombin	antithrombin	PROPN
dti-1336	136	17	,	,	PUNCT
dti-1336	136	18	protein	protein	NOUN
dti-1336	136	19	c	c	NOUN
dti-1336	136	20	,	,	PUNCT
dti-1336	136	21	or	or	CCONJ
dti-1336	136	22	protein	protein	NOUN
dti-1336	136	23	s	s	PART
dti-1336	136	24	)	)	PUNCT
dti-1336	136	25	are	be	AUX
dti-1336	136	26	generally	generally	ADV
dti-1336	136	27	initially	initially	ADV
dti-1336	136	28	treated	treat	VERB
dti-1336	136	29	as	as	ADP
dti-1336	136	30	patients	patient	NOUN
dti-1336	136	31	without	without	ADP
dti-1336	136	32	one	one	NUM
dti-1336	136	33	of	of	ADP
dti-1336	136	34	these	these	DET
dti-1336	136	35	defects	defect	NOUN
dti-1336	136	36	.	.	PUNCT
dti-1336	137	1	treatment	treatment	NOUN
dti-1336	137	2	therapy	therapy	NOUN
dti-1336	137	3	for	for	ADP
dti-1336	137	4	patients	patient	NOUN
dti-1336	137	5	with	with	ADP
dti-1336	137	6	deep	deep	ADJ
dti-1336	137	7	venous	venous	ADJ
dti-1336	137	8	thrombosis	thrombosis	NOUN
dti-1336	137	9	and	and	CCONJ
dti-1336	137	10	pulmonary	pulmonary	ADJ
dti-1336	137	11	embolism	embolism	NOUN
dti-1336	137	12	typically	typically	ADV
dti-1336	137	13	includes	include	VERB
dti-1336	137	14	administration	administration	NOUN
dti-1336	137	15	of	of	ADP
dti-1336	137	16	unfractionated	unfractionated	ADJ
dti-1336	137	17	or	or	CCONJ
dti-1336	137	18	low	low	ADJ
dti-1336	137	19	-	-	PUNCT
dti-1336	137	20	molecular	molecular	ADJ
dti-1336	137	21	-	-	PUNCT
dti-1336	137	22	weigh	weigh	NOUN
dti-1336	137	23	heparin	heparin	NOUN
dti-1336	137	24	in	in	ADP
dti-1336	137	25	therapeutic	therapeutic	ADJ
dti-1336	137	26	doses	dose	NOUN
dti-1336	137	27	,	,	PUNCT
dti-1336	137	28	followed	follow	VERB
dti-1336	137	29	by	by	ADP
dti-1336	137	30	anticoagulation	anticoagulation	NOUN
dti-1336	137	31	with	with	ADP
dti-1336	137	32	warfarin	warfarin	NOUN
dti-1336	137	33	at	at	ADP
dti-1336	137	34	an	an	DET
dti-1336	137	35	inr	inr	NOUN
dti-1336	137	36	between	between	ADP
dti-1336	137	37	2	2	NUM
dti-1336	137	38	and	and	CCONJ
dti-1336	137	39	3	3	NUM
dti-1336	137	40	for	for	ADP
dti-1336	137	41	3	3	NUM
dti-1336	137	42	to	to	PART
dti-1336	137	43	6	6	NUM
dti-1336	137	44	months	month	NOUN
dti-1336	137	45	.	.	PUNCT
dti-1336	138	1	after	after	ADP
dti-1336	138	2	cessation	cessation	NOUN
dti-1336	138	3	of	of	ADP
dti-1336	138	4	anticoagulant	anticoagulant	ADJ
dti-1336	138	5	therapy	therapy	NOUN
dti-1336	138	6	for	for	ADP
dti-1336	138	7	patients	patient	NOUN
dti-1336	138	8	with	with	ADP
dti-1336	138	9	a	a	DET
dti-1336	138	10	fi	fi	NOUN
dti-1336	138	11	rst	rst	PROPN
dti-1336	138	12	episode	episode	NOUN
dti-1336	138	13	of	of	ADP
dti-1336	138	14	symptomatic	symptomatic	ADJ
dti-1336	138	15	venous	venous	ADJ
dti-1336	138	16	thromboembolism	thromboembolism	NOUN
dti-1336	138	17	the	the	DET
dti-1336	138	18	cumulative	cumulative	ADJ
dti-1336	138	19	incidence	incidence	NOUN
dti-1336	138	20	of	of	ADP
dti-1336	138	21	recurrent	recurrent	ADJ
dti-1336	138	22	venous	venous	ADJ
dti-1336	138	23	thrombosis	thrombosis	NOUN
dti-1336	138	24	is	be	AUX
dti-1336	138	25	5	5	NUM
dti-1336	138	26	%	%	NOUN
dti-1336	138	27	to	to	PART
dti-1336	138	28	15	15	NUM
dti-1336	138	29	%	%	NOUN
dti-1336	138	30	at	at	ADP
dti-1336	138	31	1	1	NUM
dti-1336	138	32	year	year	NOUN
dti-1336	138	33	and	and	CCONJ
dti-1336	138	34	approximately	approximately	ADV
dti-1336	138	35	25	25	NUM
dti-1336	138	36	%	%	NOUN
dti-1336	138	37	at	at	ADP
dti-1336	138	38	5	5	NUM
dti-1336	138	39	years	year	NOUN
dti-1336	138	40	.	.	PUNCT
dti-1336	139	1	recurrences	recurrence	NOUN
dti-1336	139	2	are	be	AUX
dti-1336	139	3	much	much	ADV
dti-1336	139	4	less	less	ADV
dti-1336	139	5	frequent	frequent	ADJ
dti-1336	139	6	when	when	SCONJ
dti-1336	139	7	the	the	DET
dti-1336	139	8	initial	initial	ADJ
dti-1336	139	9	event	event	NOUN
dti-1336	139	10	was	be	AUX
dti-1336	139	11	associated	associate	VERB
dti-1336	139	12	with	with	ADP
dti-1336	139	13	surgery	surgery	NOUN
dti-1336	139	14	or	or	CCONJ
dti-1336	139	15	trauma	trauma	NOUN
dti-1336	139	16	.	.	PUNCT
dti-1336	140	1	it	it	PRON
dti-1336	140	2	is	be	AUX
dti-1336	140	3	unclear	unclear	ADJ
dti-1336	140	4	whether	whether	SCONJ
dti-1336	140	5	risk	risk	NOUN
dti-1336	140	6	of	of	ADP
dti-1336	140	7	recurrence	recurrence	NOUN
dti-1336	140	8	is	be	AUX
dti-1336	140	9	higher	high	ADJ
dti-1336	140	10	among	among	ADP
dti-1336	140	11	patients	patient	NOUN
dti-1336	140	12	with	with	ADP
dti-1336	140	13	a	a	DET
dti-1336	140	14	fi	fi	NOUN
dti-1336	140	15	rst	rst	PROPN
dti-1336	140	16	episode	episode	NOUN
dti-1336	140	17	of	of	ADP
dti-1336	140	18	venous	venous	ADJ
dti-1336	140	19	thromboembolism	thromboembolism	NOUN
dti-1336	140	20	associated	associate	VERB
dti-1336	140	21	with	with	ADP
dti-1336	140	22	the	the	DET
dti-1336	140	23	factor	factor	NOUN
dti-1336	140	24	v	v	ADP
dti-1336	140	25	leiden	leiden	PROPN
dti-1336	140	26	or	or	CCONJ
dti-1336	140	27	prothrombin	prothrombin	ADJ
dti-1336	140	28	g20210a	g20210a	ADJ
dti-1336	140	29	mutations	mutation	NOUN
dti-1336	140	30	than	than	ADP
dti-1336	140	31	in	in	ADP
dti-1336	140	32	those	those	PRON
dti-1336	140	33	without	without	ADP
dti-1336	140	34	a	a	DET
dti-1336	140	35	prothrombotic	prothrombotic	ADJ
dti-1336	140	36	mutation.71	mutation.71	NOUN
dti-1336	140	37	a	a	DET
dti-1336	140	38	statistically	statistically	ADV
dti-1336	140	39	signifi	signifi	NOUN
dti-1336	140	40	ca	can	AUX
dti-1336	140	41	nt	not	PART
dti-1336	140	42	higher	high	ADJ
dti-1336	140	43	incidence	incidence	NOUN
dti-1336	140	44	of	of	ADP
dti-1336	140	45	recurrence	recurrence	NOUN
dti-1336	140	46	has	have	AUX
dti-1336	140	47	been	be	AUX
dti-1336	140	48	reported	report	VERB
dti-1336	140	49	95	95	NUM
dti-1336	140	50	thrombophilia	thrombophilia	NOUN
dti-1336	140	51	drug	drug	NOUN
dti-1336	140	52	target	target	NOUN
dti-1336	140	53	insights	insight	NOUN
dti-1336	140	54	2008:3	2008:3	NUM
dti-1336	140	55	in	in	ADP
dti-1336	140	56	a	a	DET
dti-1336	140	57	subset	subset	NOUN
dti-1336	140	58	of	of	ADP
dti-1336	140	59	patients	patient	NOUN
dti-1336	140	60	who	who	PRON
dti-1336	140	61	are	be	AUX
dti-1336	140	62	heterozygous	heterozygous	ADJ
dti-1336	140	63	for	for	ADP
dti-1336	140	64	both	both	DET
dti-1336	140	65	mutations.72	mutations.72	NOUN
dti-1336	140	66	in	in	ADP
dti-1336	140	67	patients	patient	NOUN
dti-1336	140	68	with	with	ADP
dti-1336	140	69	unprovoked	unprovoked	ADJ
dti-1336	140	70	thromboembolism	thromboembolism	NOUN
dti-1336	140	71	,	,	PUNCT
dti-1336	140	72	the	the	DET
dti-1336	140	73	risk	risk	NOUN
dti-1336	140	74	of	of	ADP
dti-1336	140	75	recurrent	recurrent	ADJ
dti-1336	140	76	thrombosis	thrombosis	NOUN
dti-1336	140	77	in	in	ADP
dti-1336	140	78	the	the	DET
dti-1336	140	79	presence	presence	NOUN
dti-1336	140	80	of	of	ADP
dti-1336	140	81	antithrombin	antithrombin	PROPN
dti-1336	140	82	,	,	PUNCT
dti-1336	140	83	protein	protein	NOUN
dti-1336	140	84	c	c	NOUN
dti-1336	140	85	,	,	PUNCT
dti-1336	140	86	and	and	CCONJ
dti-1336	140	87	protein	protein	NOUN
dti-1336	140	88	s	s	PART
dti-1336	140	89	defi	defi	NOUN
dti-1336	140	90	ciencies	ciencie	NOUN
dti-1336	140	91	is	be	AUX
dti-1336	140	92	not	not	PART
dti-1336	140	93	known	know	VERB
dti-1336	140	94	.	.	PUNCT
dti-1336	141	1	it	it	PRON
dti-1336	141	2	is	be	AUX
dti-1336	141	3	common	common	ADJ
dti-1336	141	4	practice	practice	NOUN
dti-1336	141	5	that	that	SCONJ
dti-1336	141	6	patients	patient	NOUN
dti-1336	141	7	with	with	ADP
dti-1336	141	8	heterozygous	heterozygous	ADJ
dti-1336	141	9	antithrombin	antithrombin	ADJ
dti-1336	141	10	deficiency	deficiency	NOUN
dti-1336	141	11	receive	receive	VERB
dti-1336	141	12	anticoagulation	anticoagulation	NOUN
dti-1336	141	13	for	for	ADP
dti-1336	141	14	an	an	DET
dti-1336	141	15	indefi	indefi	NOUN
dti-1336	141	16	nite	nite	ADJ
dti-1336	141	17	period	period	NOUN
dti-1336	141	18	of	of	ADP
dti-1336	141	19	time	time	NOUN
dti-1336	141	20	because	because	SCONJ
dti-1336	141	21	they	they	PRON
dti-1336	141	22	appear	appear	VERB
dti-1336	141	23	more	more	ADV
dti-1336	141	24	prone	prone	ADJ
dti-1336	141	25	to	to	ADP
dti-1336	141	26	thrombosis	thrombosis	NOUN
dti-1336	141	27	than	than	ADP
dti-1336	141	28	patients	patient	NOUN
dti-1336	141	29	with	with	ADP
dti-1336	141	30	other	other	ADJ
dti-1336	141	31	single	single	ADJ
dti-1336	141	32	heritable	heritable	ADJ
dti-1336	141	33	abnormalities	abnormality	NOUN
dti-1336	141	34	.	.	PUNCT
dti-1336	142	1	in	in	ADP
dti-1336	142	2	the	the	DET
dti-1336	142	3	setting	setting	NOUN
dti-1336	142	4	of	of	ADP
dti-1336	142	5	arterial	arterial	ADJ
dti-1336	142	6	thrombosis	thrombosis	NOUN
dti-1336	142	7	,	,	PUNCT
dti-1336	142	8	most	most	ADJ
dti-1336	142	9	studies	study	NOUN
dti-1336	142	10	indicate	indicate	VERB
dti-1336	142	11	that	that	SCONJ
dti-1336	142	12	the	the	DET
dti-1336	142	13	presence	presence	NOUN
dti-1336	142	14	of	of	ADP
dti-1336	142	15	hereditary	hereditary	ADJ
dti-1336	142	16	thrombophilias	thrombophilia	NOUN
dti-1336	142	17	does	do	AUX
dti-1336	142	18	not	not	PART
dti-1336	142	19	constitute	constitute	VERB
dti-1336	142	20	a	a	DET
dti-1336	142	21	risk	risk	NOUN
dti-1336	142	22	factor	factor	NOUN
dti-1336	142	23	.	.	PUNCT
dti-1336	143	1	it	it	PRON
dti-1336	143	2	is	be	AUX
dti-1336	143	3	not	not	PART
dti-1336	143	4	recommended	recommend	VERB
dti-1336	143	5	to	to	PART
dti-1336	143	6	investigate	investigate	VERB
dti-1336	143	7	for	for	ADP
dti-1336	143	8	the	the	DET
dti-1336	143	9	hereditary	hereditary	ADJ
dti-1336	143	10	thrombophilias	thrombophilia	NOUN
dti-1336	143	11	in	in	ADP
dti-1336	143	12	patients	patient	NOUN
dti-1336	143	13	who	who	PRON
dti-1336	143	14	have	have	AUX
dti-1336	143	15	isolated	isolate	VERB
dti-1336	143	16	arterial	arterial	ADJ
dti-1336	143	17	thrombosis	thrombosis	NOUN
dti-1336	143	18	,	,	PUNCT
dti-1336	143	19	in	in	ADP
dti-1336	143	20	the	the	DET
dti-1336	143	21	presence	presence	NOUN
dti-1336	143	22	of	of	ADP
dti-1336	143	23	other	other	ADJ
dti-1336	143	24	independent	independent	ADJ
dti-1336	143	25	cardiovascular	cardiovascular	ADJ
dti-1336	143	26	risk	risk	NOUN
dti-1336	143	27	factors	factor	NOUN
dti-1336	143	28	(	(	PUNCT
dti-1336	143	29	hypertension	hypertension	NOUN
dti-1336	143	30	or	or	CCONJ
dti-1336	143	31	diabetes	diabetes	NOUN
dti-1336	143	32	mellitus	mellitus	NOUN
dti-1336	143	33	or	or	CCONJ
dti-1336	143	34	if	if	SCONJ
dti-1336	143	35	they	they	PRON
dti-1336	143	36	smoke	smoke	VERB
dti-1336	143	37	or	or	CCONJ
dti-1336	143	38	have	have	VERB
dti-1336	143	39	hyperlipidemia	hyperlipidemia	NOUN
dti-1336	143	40	)	)	PUNCT
dti-1336	143	41	.	.	PUNCT
dti-1336	144	1	most	most	ADJ
dti-1336	144	2	patients	patient	NOUN
dti-1336	144	3	with	with	ADP
dti-1336	144	4	an	an	DET
dti-1336	144	5	antiphospholipid	antiphospholipid	NOUN
dti-1336	144	6	antibody	antibody	NOUN
dti-1336	144	7	are	be	AUX
dti-1336	144	8	adequately	adequately	ADV
dti-1336	144	9	treated	treat	VERB
dti-1336	144	10	with	with	ADP
dti-1336	144	11	warfarin	warfarin	NOUN
dti-1336	144	12	administered	administer	VERB
dti-1336	144	13	to	to	PART
dti-1336	144	14	achieve	achieve	VERB
dti-1336	144	15	an	an	DET
dti-1336	144	16	inr	inr	NOUN
dti-1336	144	17	of	of	ADP
dti-1336	144	18	2.0–3.0	2.0–3.0	NUM
dti-1336	144	19	.	.	PUNCT
dti-1336	145	1	the	the	DET
dti-1336	145	2	addition	addition	NOUN
dti-1336	145	3	of	of	ADP
dti-1336	145	4	aspirin	aspirin	NOUN
dti-1336	145	5	to	to	PART
dti-1336	145	6	warfarin	warfarin	NOUN
dti-1336	145	7	for	for	ADP
dti-1336	145	8	those	those	DET
dti-1336	145	9	patients	patient	NOUN
dti-1336	145	10	with	with	ADP
dti-1336	145	11	arterial	arterial	ADJ
dti-1336	145	12	thrombosis	thrombosis	NOUN
dti-1336	145	13	is	be	AUX
dti-1336	145	14	reasonable	reasonable	ADJ
dti-1336	145	15	.	.	PUNCT
dti-1336	146	1	patients	patient	NOUN
dti-1336	146	2	with	with	ADP
dti-1336	146	3	recurrent	recurrent	ADJ
dti-1336	146	4	thrombosis	thrombosis	NOUN
dti-1336	146	5	despite	despite	SCONJ
dti-1336	146	6	“	"	PUNCT
dti-1336	146	7	usual	usual	ADJ
dti-1336	146	8	intensity	intensity	NOUN
dti-1336	146	9	warfarin	warfarin	NOUN
dti-1336	146	10	”	"	PUNCT
dti-1336	146	11	therapy	therapy	NOUN
dti-1336	146	12	can	can	AUX
dti-1336	146	13	be	be	AUX
dti-1336	146	14	treated	treat	VERB
dti-1336	146	15	with	with	ADP
dti-1336	146	16	heparin	heparin	ADJ
dti-1336	146	17	or	or	CCONJ
dti-1336	146	18	low	low	ADJ
dti-1336	146	19	molecular	molecular	ADJ
dti-1336	146	20	weight	weight	NOUN
dti-1336	146	21	heparin	heparin	NOUN
dti-1336	146	22	(	(	PUNCT
dti-1336	146	23	lmwh	lmwh	NOUN
dti-1336	146	24	)	)	PUNCT
dti-1336	146	25	administered	administer	VERB
dti-1336	146	26	subcutaneously	subcutaneously	ADV
dti-1336	146	27	in	in	ADP
dti-1336	146	28	therapeutic	therapeutic	ADJ
dti-1336	146	29	doses	dose	NOUN
dti-1336	146	30	.	.	PUNCT
dti-1336	147	1	higher	high	ADJ
dti-1336	147	2	doses	dose	NOUN
dti-1336	147	3	of	of	ADP
dti-1336	147	4	warfarin	warfarin	NOUN
dti-1336	147	5	(	(	PUNCT
dti-1336	147	6	target	target	VERB
dti-1336	147	7	inr	inr	NOUN
dti-1336	147	8	of	of	ADP
dti-1336	147	9	3.0–4.0	3.0–4.0	NUM
dti-1336	147	10	in	in	ADP
dti-1336	147	11	combination	combination	NOUN
dti-1336	147	12	with	with	ADP
dti-1336	147	13	aspirin	aspirin	NOUN
dti-1336	147	14	)	)	PUNCT
dti-1336	147	15	might	might	AUX
dti-1336	147	16	also	also	ADV
dti-1336	147	17	be	be	AUX
dti-1336	147	18	considered	consider	VERB
dti-1336	147	19	in	in	ADP
dti-1336	147	20	such	such	ADJ
dti-1336	147	21	patients	patient	NOUN
dti-1336	147	22	.	.	PUNCT
dti-1336	148	1	because	because	SCONJ
dti-1336	148	2	of	of	ADP
dti-1336	148	3	the	the	DET
dti-1336	148	4	high	high	ADJ
dti-1336	148	5	risk	risk	NOUN
dti-1336	148	6	of	of	ADP
dti-1336	148	7	recurrent	recurrent	ADJ
dti-1336	148	8	thrombosis	thrombosis	NOUN
dti-1336	148	9	off	off	ADP
dti-1336	148	10	anticoagulation	anticoagulation	NOUN
dti-1336	148	11	,	,	PUNCT
dti-1336	148	12	retrospective	retrospective	ADJ
dti-1336	148	13	studies	study	NOUN
dti-1336	148	14	have	have	AUX
dti-1336	148	15	suggested	suggest	VERB
dti-1336	148	16	that	that	SCONJ
dti-1336	148	17	patients	patient	NOUN
dti-1336	148	18	with	with	ADP
dti-1336	148	19	antiphospholipid	antiphospholipid	NOUN
dti-1336	148	20	antibody	antibody	NOUN
dti-1336	148	21	syndrome	syndrome	NOUN
dti-1336	148	22	require	require	VERB
dti-1336	148	23	indefi	indefi	PROPN
dti-1336	148	24	nite	nite	PROPN
dti-1336	148	25	treatment	treatment	NOUN
dti-1336	148	26	.	.	PUNCT
dti-1336	149	1	even	even	ADV
dti-1336	149	2	if	if	SCONJ
dti-1336	149	3	a	a	DET
dti-1336	149	4	signifi	signifi	NOUN
dti-1336	149	5	ca	can	AUX
dti-1336	149	6	nt	not	PART
dti-1336	149	7	body	body	VERB
dti-1336	149	8	of	of	ADP
dti-1336	149	9	evidence73,74	evidence73,74	NOUN
dti-1336	149	10	suggests	suggest	VERB
dti-1336	149	11	a	a	DET
dti-1336	149	12	survival	survival	NOUN
dti-1336	149	13	advantage	advantage	NOUN
dti-1336	149	14	in	in	ADP
dti-1336	149	15	cancer	cancer	NOUN
dti-1336	149	16	patients	patient	NOUN
dti-1336	149	17	treated	treat	VERB
dti-1336	149	18	with	with	ADP
dti-1336	149	19	lmwh	lmwh	ADJ
dti-1336	149	20	,	,	PUNCT
dti-1336	149	21	routine	routine	ADJ
dti-1336	149	22	administration	administration	NOUN
dti-1336	149	23	of	of	ADP
dti-1336	149	24	anticoagulant	anticoagulant	NOUN
dti-1336	149	25	is	be	AUX
dti-1336	149	26	not	not	PART
dti-1336	149	27	recommended	recommend	VERB
dti-1336	149	28	.	.	PUNCT
dti-1336	150	1	primary	primary	ADJ
dti-1336	150	2	prophylaxis	prophylaxis	NOUN
dti-1336	150	3	for	for	ADP
dti-1336	150	4	thromboembolism	thromboembolism	NOUN
dti-1336	150	5	is	be	AUX
dti-1336	150	6	recommended	recommend	VERB
dti-1336	150	7	unfractionated	unfractionate	VERB
dti-1336	150	8	heparin	heparin	NOUN
dti-1336	150	9	(	(	PUNCT
dti-1336	150	10	ufh	ufh	PROPN
dti-1336	150	11	)	)	PUNCT
dti-1336	150	12	,	,	PUNCT
dti-1336	150	13	or	or	CCONJ
dti-1336	150	14	lmwh	lmwh	NOUN
dti-1336	150	15	in	in	ADP
dti-1336	150	16	cancer	cancer	NOUN
dti-1336	150	17	patients	patient	NOUN
dti-1336	150	18	who	who	PRON
dti-1336	150	19	are	be	AUX
dti-1336	150	20	to	to	PART
dti-1336	150	21	undergo	undergo	VERB
dti-1336	150	22	surgery	surgery	NOUN
dti-1336	150	23	;	;	PUNCT
dti-1336	150	24	such	such	ADJ
dti-1336	150	25	patients	patient	NOUN
dti-1336	150	26	have	have	VERB
dti-1336	150	27	a	a	DET
dti-1336	150	28	post	post	ADJ
dti-1336	150	29	operative	operative	ADJ
dti-1336	150	30	thromboembolic	thromboembolic	ADJ
dti-1336	150	31	risk	risk	NOUN
dti-1336	150	32	3	3	NUM
dti-1336	150	33	times	time	NOUN
dti-1336	150	34	higher	high	ADJ
dti-1336	150	35	of	of	ADP
dti-1336	150	36	non	non	ADJ
dti-1336	150	37	cancer	cancer	NOUN
dti-1336	150	38	individuals	individual	NOUN
dti-1336	150	39	.	.	PUNCT
dti-1336	151	1	all	all	PRON
dti-1336	151	2	hospitalized	hospitalize	VERB
dti-1336	151	3	acutely	acutely	ADV
dti-1336	151	4	ill	ill	ADJ
dti-1336	151	5	individuals	individual	NOUN
dti-1336	151	6	with	with	ADP
dti-1336	151	7	active	active	ADJ
dti-1336	151	8	cancer	cancer	NOUN
dti-1336	151	9	should	should	AUX
dti-1336	151	10	receive	receive	VERB
dti-1336	151	11	anticoagulant	anticoagulant	NOUN
dti-1336	151	12	prophylaxis	prophylaxis	NOUN
dti-1336	151	13	with	with	ADP
dti-1336	151	14	low	low	ADJ
dti-1336	151	15	dose	dose	NOUN
dti-1336	151	16	ufh	ufh	PROPN
dti-1336	151	17	or	or	CCONJ
dti-1336	151	18	lmwh.75,76	lmwh.75,76	VERB
dti-1336	151	19	with	with	ADP
dti-1336	151	20	the	the	DET
dti-1336	151	21	current	current	ADJ
dti-1336	151	22	practice	practice	NOUN
dti-1336	151	23	in	in	ADP
dti-1336	151	24	oncology	oncology	NOUN
dti-1336	151	25	being	be	AUX
dti-1336	151	26	dominated	dominate	VERB
dti-1336	151	27	by	by	ADP
dti-1336	151	28	outpatient	outpatient	NOUN
dti-1336	151	29	care	care	NOUN
dti-1336	151	30	with	with	ADP
dti-1336	151	31	the	the	DET
dti-1336	151	32	more	more	ADV
dti-1336	151	33	frequent	frequent	ADJ
dti-1336	151	34	use	use	NOUN
dti-1336	151	35	of	of	ADP
dti-1336	151	36	active	active	ADJ
dti-1336	151	37	anticancer	anticancer	NOUN
dti-1336	151	38	drugs	drug	NOUN
dti-1336	151	39	with	with	ADP
dti-1336	151	40	prothrombogenic	prothrombogenic	ADJ
dti-1336	151	41	activity	activity	NOUN
dti-1336	151	42	,	,	PUNCT
dti-1336	151	43	the	the	DET
dti-1336	151	44	physician	physician	NOUN
dti-1336	151	45	should	should	AUX
dti-1336	151	46	watch	watch	VERB
dti-1336	151	47	for	for	ADP
dti-1336	151	48	signs	sign	NOUN
dti-1336	151	49	or	or	CCONJ
dti-1336	151	50	symptoms	symptom	NOUN
dti-1336	151	51	of	of	ADP
dti-1336	151	52	vte	vte	NOUN
dti-1336	151	53	and	and	CCONJ
dti-1336	151	54	patients	patient	NOUN
dti-1336	151	55	seeking	seek	VERB
dti-1336	151	56	immediate	immediate	ADJ
dti-1336	151	57	medical	medical	ADJ
dti-1336	151	58	attention	attention	NOUN
dti-1336	151	59	for	for	ADP
dti-1336	151	60	symptoms	symptom	NOUN
dti-1336	151	61	such	such	ADJ
dti-1336	151	62	as	as	ADP
dti-1336	151	63	chest	chest	NOUN
dti-1336	151	64	pain	pain	NOUN
dti-1336	151	65	,	,	PUNCT
dti-1336	151	66	shortness	shortness	NOUN
dti-1336	151	67	of	of	ADP
dti-1336	151	68	breath	breath	NOUN
dti-1336	151	69	or	or	CCONJ
dti-1336	151	70	lower	low	ADJ
dti-1336	151	71	extremities	extremity	NOUN
dti-1336	151	72	swelling	swell	VERB
dti-1336	151	73	.	.	PUNCT
dti-1336	152	1	in	in	ADP
dti-1336	152	2	patients	patient	NOUN
dti-1336	152	3	treated	treat	VERB
dti-1336	152	4	with	with	ADP
dti-1336	152	5	a	a	DET
dti-1336	152	6	combination	combination	NOUN
dti-1336	152	7	of	of	ADP
dti-1336	152	8	immunomodulatory	immunomodulatory	ADJ
dti-1336	152	9	drugs	drug	NOUN
dti-1336	152	10	such	such	ADJ
dti-1336	152	11	as	as	ADP
dti-1336	152	12	thalidomide	thalidomide	NOUN
dti-1336	152	13	,	,	PUNCT
dti-1336	152	14	with	with	ADP
dti-1336	152	15	chemotherapy	chemotherapy	NOUN
dti-1336	152	16	or	or	CCONJ
dti-1336	152	17	steroids	steroid	NOUN
dti-1336	152	18	,	,	PUNCT
dti-1336	152	19	has	have	AUX
dti-1336	152	20	now	now	ADV
dti-1336	152	21	become	become	VERB
dti-1336	152	22	common	common	ADJ
dti-1336	152	23	practice	practice	NOUN
dti-1336	152	24	with	with	ADP
dti-1336	152	25	the	the	DET
dti-1336	152	26	use	use	NOUN
dti-1336	152	27	of	of	ADP
dti-1336	152	28	a	a	DET
dti-1336	152	29	prophylactic	prophylactic	ADJ
dti-1336	152	30	dose	dose	NOUN
dti-1336	152	31	of	of	ADP
dti-1336	152	32	lmwh	lmwh	NOUN
dti-1336	152	33	or	or	CCONJ
dti-1336	152	34	coumadin	coumadin	NOUN
dti-1336	152	35	,	,	PUNCT
dti-1336	152	36	especially	especially	ADV
dti-1336	152	37	during	during	ADP
dti-1336	152	38	the	the	DET
dti-1336	152	39	early	early	ADJ
dti-1336	152	40	courses	course	NOUN
dti-1336	152	41	of	of	ADP
dti-1336	152	42	cancer	cancer	NOUN
dti-1336	152	43	chemotherapy.77	chemotherapy.77	NOUN
dti-1336	152	44	acknowledgments	acknowledgment	NOUN
dti-1336	152	45	we	we	PRON
dti-1336	152	46	wish	wish	VERB
dti-1336	152	47	to	to	PART
dti-1336	152	48	thank	thank	VERB
dti-1336	152	49	ashlie	ashlie	PROPN
dti-1336	152	50	finlayson	finlayson	PROPN
dti-1336	152	51	for	for	ADP
dti-1336	152	52	excellent	excellent	ADJ
dti-1336	152	53	technical	technical	ADJ
dti-1336	152	54	assistance	assistance	NOUN
dti-1336	152	55	.	.	PUNCT
dti-1336	153	1	references	reference	NOUN
dti-1336	153	2	[	[	X
dti-1336	153	3	1	1	NUM
dti-1336	153	4	]	]	PUNCT
dti-1336	153	5	bauer	bauer	PROPN
dti-1336	153	6	,	,	PUNCT
dti-1336	153	7	k.a	k.a	PROPN
dti-1336	153	8	.	.	PROPN
dti-1336	153	9	new	new	PROPN
dti-1336	153	10	york	york	PROPN
dti-1336	153	11	,	,	PUNCT
dti-1336	153	12	2005	2005	NUM
dti-1336	153	13	.	.	PUNCT
dti-1336	154	1	hypercoagulable	hypercoagulable	ADJ
dti-1336	154	2	states	state	NOUN
dti-1336	154	3	.	.	PUNCT
dti-1336	155	1	in	in	ADP
dti-1336	155	2	hoffman	hoffman	PROPN
dti-1336	155	3	r.	r.	PROPN
dti-1336	155	4	(	(	PUNCT
dti-1336	155	5	ed	ed	NOUN
dti-1336	155	6	):	):	PUNCT
dti-1336	155	7	hematology	hematology	NOUN
dti-1336	155	8	-	-	PUNCT
dti-1336	155	9	basic	basic	ADJ
dti-1336	155	10	and	and	CCONJ
dti-1336	155	11	principle	principle	NOUN
dti-1336	155	12	and	and	CCONJ
dti-1336	155	13	practice	practice	NOUN
dti-1336	155	14	,	,	PUNCT
dti-1336	155	15	4th	4th	ADJ
dti-1336	155	16	ed	ed	NOUN
dti-1336	155	17	.	.	PUNCT
dti-1336	155	18	churchill	churchill	PROPN
dti-1336	155	19	livingstone	livingstone	PROPN
dti-1336	155	20	,	,	PUNCT
dti-1336	155	21	2197–224	2197–224	ADV
dti-1336	155	22	.	.	PUNCT
dti-1336	156	1	[	[	X
dti-1336	156	2	2	2	NUM
dti-1336	156	3	]	]	X
dti-1336	156	4	lensen	lensen	PROPN
dti-1336	156	5	,	,	PUNCT
dti-1336	156	6	r.p	r.p	PROPN
dti-1336	156	7	.	.	PROPN
dti-1336	156	8	,	,	PUNCT
dti-1336	156	9	bertina	bertina	PROPN
dti-1336	156	10	,	,	PUNCT
dti-1336	156	11	r.m	r.m	PROPN
dti-1336	156	12	.	.	PROPN
dti-1336	156	13	,	,	PUNCT
dti-1336	156	14	de	de	X
dti-1336	156	15	ronde	ronde	X
dti-1336	156	16	,	,	PUNCT
dti-1336	156	17	h.	h.	PROPN
dti-1336	156	18	,	,	PUNCT
dti-1336	156	19	vandenbroucke	vandenbroucke	NOUN
dti-1336	156	20	,	,	PUNCT
dti-1336	156	21	j.p	j.p	PROPN
dti-1336	156	22	.	.	PROPN
dti-1336	156	23	and	and	CCONJ
dti-1336	156	24	rosendaal	rosendaal	PROPN
dti-1336	156	25	,	,	PUNCT
dti-1336	156	26	f.r	f.r	PROPN
dti-1336	156	27	.	.	NOUN
dti-1336	156	28	2000a	2000a	NOUN
dti-1336	156	29	.	.	PUNCT
dti-1336	157	1	venous	venous	ADJ
dti-1336	157	2	thrombotic	thrombotic	ADJ
dti-1336	157	3	risk	risk	NOUN
dti-1336	157	4	in	in	ADP
dti-1336	157	5	family	family	NOUN
dti-1336	157	6	members	member	NOUN
dti-1336	157	7	of	of	ADP
dti-1336	157	8	unselected	unselected	ADJ
dti-1336	157	9	individuals	individual	NOUN
dti-1336	157	10	with	with	ADP
dti-1336	157	11	factor	factor	NOUN
dti-1336	157	12	v	v	PROPN
dti-1336	157	13	leiden	leiden	PROPN
dti-1336	157	14	.	.	PUNCT
dti-1336	158	1	thromb	thromb	PROPN
dti-1336	158	2	.	.	PUNCT
dti-1336	159	1	haemost	haemost	PROPN
dti-1336	159	2	.	.	PUNCT
dti-1336	159	3	,	,	PUNCT
dti-1336	159	4	83:817–21	83:817–21	NOUN
dti-1336	159	5	.	.	PUNCT
dti-1336	160	1	[	[	X
dti-1336	160	2	3	3	NUM
dti-1336	160	3	]	]	X
dti-1336	160	4	lensen	lensen	PROPN
dti-1336	160	5	,	,	PUNCT
dti-1336	160	6	r.	r.	PROPN
dti-1336	160	7	,	,	PUNCT
dti-1336	160	8	rosendaal	rosendaal	PROPN
dti-1336	160	9	,	,	PUNCT
dti-1336	160	10	f.	f.	PROPN
dti-1336	160	11	,	,	PUNCT
dti-1336	160	12	vandenbroucke	vandenbroucke	NOUN
dti-1336	160	13	,	,	PUNCT
dti-1336	160	14	j.	j.	PROPN
dti-1336	160	15	and	and	CCONJ
dti-1336	160	16	bertina	bertina	PROPN
dti-1336	160	17	,	,	PUNCT
dti-1336	160	18	r.	r.	PROPN
dti-1336	160	19	2000b	2000b	NUM
dti-1336	160	20	.	.	PUNCT
dti-1336	161	1	factor	factor	PROPN
dti-1336	161	2	v	v	PROPN
dti-1336	161	3	leiden	leiden	PROPN
dti-1336	161	4	:	:	PUNCT
dti-1336	161	5	the	the	DET
dti-1336	161	6	venous	venous	ADJ
dti-1336	161	7	thrombotic	thrombotic	ADJ
dti-1336	161	8	risk	risk	NOUN
dti-1336	161	9	in	in	ADP
dti-1336	161	10	thrombophilic	thrombophilic	ADJ
dti-1336	161	11	families	family	NOUN
dti-1336	161	12	.	.	PUNCT
dti-1336	162	1	br	br	X
dti-1336	162	2	.	.	PUNCT
dti-1336	163	1	j.	j.	PROPN
dti-1336	163	2	haematol	haematol	PROPN
dti-1336	163	3	.	.	PUNCT
dti-1336	163	4	,	,	PUNCT
dti-1336	163	5	110:939–45	110:939–45	NUM
dti-1336	163	6	.	.	PUNCT
dti-1336	164	1	[	[	X
dti-1336	164	2	4	4	NUM
dti-1336	164	3	]	]	X
dti-1336	164	4	koster	koster	NOUN
dti-1336	164	5	,	,	PUNCT
dti-1336	164	6	t.	t.	PROPN
dti-1336	164	7	,	,	PUNCT
dti-1336	164	8	rosendaal	rosendaal	PROPN
dti-1336	164	9	,	,	PUNCT
dti-1336	164	10	f.r	f.r	PROPN
dti-1336	164	11	.	.	PROPN
dti-1336	164	12	,	,	PUNCT
dti-1336	164	13	briët	briët	PROPN
dti-1336	164	14	,	,	PUNCT
dti-1336	164	15	e.	e.	PROPN
dti-1336	164	16	et	et	PROPN
dti-1336	164	17	al	al	PROPN
dti-1336	164	18	.	.	PROPN
dti-1336	164	19	1995	1995	NUM
dti-1336	164	20	.	.	PUNCT
dti-1336	165	1	protein	protein	NOUN
dti-1336	165	2	c	c	PROPN
dti-1336	165	3	defi	defi	NOUN
dti-1336	165	4	ciency	ciency	NOUN
dti-1336	165	5	in	in	ADP
dti-1336	165	6	a	a	DET
dti-1336	165	7	controlled	control	VERB
dti-1336	165	8	series	series	NOUN
dti-1336	165	9	of	of	ADP
dti-1336	165	10	unselected	unselected	ADJ
dti-1336	165	11	outpatients	outpatient	NOUN
dti-1336	165	12	:	:	PUNCT
dti-1336	165	13	an	an	DET
dti-1336	165	14	infrequent	infrequent	ADJ
dti-1336	165	15	but	but	CCONJ
dti-1336	165	16	clear	clear	ADJ
dti-1336	165	17	risk	risk	NOUN
dti-1336	165	18	factor	factor	NOUN
dti-1336	165	19	for	for	ADP
dti-1336	165	20	venous	venous	ADJ
dti-1336	165	21	thrombosis	thrombosis	NOUN
dti-1336	165	22	(	(	PUNCT
dti-1336	165	23	leiden	leiden	PROPN
dti-1336	165	24	thrombophilia	thrombophilia	PROPN
dti-1336	165	25	study	study	PROPN
dti-1336	165	26	)	)	PUNCT
dti-1336	165	27	.	.	PUNCT
dti-1336	166	1	blood	blood	NOUN
dti-1336	166	2	,	,	PUNCT
dti-1336	166	3	85:2756–61	85:2756–61	NUM
dti-1336	166	4	.	.	PUNCT
dti-1336	167	1	[	[	X
dti-1336	167	2	5	5	NUM
dti-1336	167	3	]	]	X
dti-1336	167	4	tait	tait	X
dti-1336	167	5	,	,	PUNCT
dti-1336	167	6	r.c	r.c	PROPN
dti-1336	167	7	.	.	PROPN
dti-1336	167	8	,	,	PUNCT
dti-1336	167	9	walker	walker	PROPN
dti-1336	167	10	,	,	PUNCT
dti-1336	167	11	i.d	i.d	PROPN
dti-1336	167	12	.	.	PROPN
dti-1336	167	13	,	,	PUNCT
dti-1336	167	14	perry	perry	PROPN
dti-1336	167	15	,	,	PUNCT
dti-1336	167	16	d.j	d.j	PROPN
dti-1336	167	17	.	.	PROPN
dti-1336	167	18	et	et	PROPN
dti-1336	167	19	al	al	PROPN
dti-1336	167	20	.	.	PROPN
dti-1336	167	21	1994	1994	NUM
dti-1336	167	22	.	.	PUNCT
dti-1336	168	1	prevalence	prevalence	NOUN
dti-1336	168	2	of	of	ADP
dti-1336	168	3	antithrombin	antithrombin	PROPN
dti-1336	168	4	defi	defi	PROPN
dti-1336	168	5	ciency	ciency	NOUN
dti-1336	168	6	in	in	ADP
dti-1336	168	7	the	the	DET
dti-1336	168	8	healthy	healthy	ADJ
dti-1336	168	9	population	population	NOUN
dti-1336	168	10	.	.	PUNCT
dti-1336	169	1	br	br	PROPN
dti-1336	169	2	.	.	PUNCT
dti-1336	170	1	j.	j.	PROPN
dti-1336	170	2	haematol	haematol	PROPN
dti-1336	170	3	.	.	PROPN
dti-1336	170	4	,	,	PUNCT
dti-1336	170	5	87:106–12	87:106–12	NOUN
dti-1336	170	6	.	.	PUNCT
dti-1336	171	1	[	[	X
dti-1336	171	2	6	6	NUM
dti-1336	171	3	]	]	X
dti-1336	171	4	van	van	PROPN
dti-1336	171	5	der	der	PROPN
dti-1336	171	6	meer	meer	PROPN
dti-1336	171	7	,	,	PUNCT
dti-1336	171	8	f.j	f.j	PROPN
dti-1336	171	9	.	.	PROPN
dti-1336	171	10	,	,	PUNCT
dti-1336	171	11	koster	koster	PROPN
dti-1336	171	12	,	,	PUNCT
dti-1336	171	13	t.	t.	PROPN
dti-1336	171	14	,	,	PUNCT
dti-1336	171	15	vandenbroucke	vandenbroucke	NOUN
dti-1336	171	16	,	,	PUNCT
dti-1336	171	17	j.p	j.p	PROPN
dti-1336	171	18	.	.	PROPN
dti-1336	171	19	,	,	PUNCT
dti-1336	171	20	briet	briet	PROPN
dti-1336	171	21	,	,	PUNCT
dti-1336	171	22	e.	e.	PROPN
dti-1336	171	23	and	and	CCONJ
dti-1336	171	24	rosendaal	rosendaal	PROPN
dti-1336	171	25	,	,	PUNCT
dti-1336	171	26	f.r	f.r	PROPN
dti-1336	171	27	.	.	NOUN
dti-1336	171	28	1997	1997	NUM
dti-1336	171	29	jul	jul	PROPN
dti-1336	171	30	.	.	PUNCT
dti-1336	172	1	the	the	DET
dti-1336	172	2	leiden	leiden	PROPN
dti-1336	172	3	thrombophilia	thrombophilia	PROPN
dti-1336	172	4	study	study	PROPN
dti-1336	172	5	(	(	PUNCT
dti-1336	172	6	lets	let	NOUN
dti-1336	172	7	)	)	PUNCT
dti-1336	172	8	.	.	PUNCT
dti-1336	173	1	thromb	thromb	NOUN
dti-1336	173	2	.	.	PUNCT
dti-1336	174	1	haemost	haemost	PROPN
dti-1336	174	2	.	.	PUNCT
dti-1336	174	3	,	,	PUNCT
dti-1336	175	1	78(1):631–5	78(1):631–5	X
dti-1336	175	2	.	.	PUNCT
dti-1336	176	1	[	[	X
dti-1336	176	2	7	7	NUM
dti-1336	176	3	]	]	X
dti-1336	176	4	lane	lane	NOUN
dti-1336	176	5	,	,	PUNCT
dti-1336	176	6	d.a	d.a	PROPN
dti-1336	176	7	.	.	PROPN
dti-1336	176	8	,	,	PUNCT
dti-1336	176	9	bayston	bayston	PROPN
dti-1336	176	10	,	,	PUNCT
dti-1336	176	11	t.	t.	NOUN
dti-1336	176	12	,	,	PUNCT
dti-1336	176	13	olds	old	NOUN
dti-1336	176	14	,	,	PUNCT
dti-1336	176	15	r.j	r.j	PROPN
dti-1336	176	16	.	.	PROPN
dti-1336	176	17	et	et	PROPN
dti-1336	176	18	al	al	PROPN
dti-1336	176	19	.	.	PROPN
dti-1336	176	20	1997	1997	NUM
dti-1336	176	21	.	.	PUNCT
dti-1336	176	22	antithrombin	antithrombin	NOUN
dti-1336	176	23	mutation	mutation	NOUN
dti-1336	176	24	database	database	NOUN
dti-1336	176	25	:	:	PUNCT
dti-1336	176	26	2nd	2nd	ADJ
dti-1336	176	27	(	(	PUNCT
dti-1336	176	28	1997	1997	NUM
dti-1336	176	29	)	)	PUNCT
dti-1336	176	30	update	update	NOUN
dti-1336	176	31	.	.	PUNCT
dti-1336	177	1	for	for	ADP
dti-1336	177	2	the	the	DET
dti-1336	177	3	plasma	plasma	NOUN
dti-1336	177	4	coagulation	coagulation	NOUN
dti-1336	177	5	inhibitors	inhibitor	NOUN
dti-1336	177	6	subcommittee	subcommittee	NOUN
dti-1336	177	7	of	of	ADP
dti-1336	177	8	the	the	DET
dti-1336	177	9	scientifi	scientifi	NOUN
dti-1336	177	10	c	c	PROPN
dti-1336	177	11	and	and	CCONJ
dti-1336	177	12	standardization	standardization	NOUN
dti-1336	177	13	committee	committee	NOUN
dti-1336	177	14	of	of	ADP
dti-1336	177	15	the	the	DET
dti-1336	177	16	international	international	ADJ
dti-1336	177	17	society	society	NOUN
dti-1336	177	18	on	on	ADP
dti-1336	177	19	thrombosis	thrombosis	NOUN
dti-1336	177	20	and	and	CCONJ
dti-1336	177	21	haemostasis	haemostasis	NOUN
dti-1336	177	22	.	.	PUNCT
dti-1336	178	1	throm	throm	X
dti-1336	178	2	.	.	PUNCT
dti-1336	179	1	haemost	haemost	PROPN
dti-1336	179	2	.	.	PUNCT
dti-1336	179	3	,	,	PUNCT
dti-1336	179	4	77:197	77:197	NUM
dti-1336	179	5	.	.	PUNCT
dti-1336	180	1	[	[	X
dti-1336	180	2	8	8	NUM
dti-1336	180	3	]	]	X
dti-1336	180	4	martinelli	martinelli	PROPN
dti-1336	180	5	,	,	PUNCT
dti-1336	180	6	i.	i.	PROPN
dti-1336	180	7	,	,	PUNCT
dti-1336	180	8	mannucci	mannucci	PROPN
dti-1336	180	9	,	,	PUNCT
dti-1336	180	10	p.m.	p.m.	NOUN
dti-1336	180	11	,	,	PUNCT
dti-1336	180	12	de	de	PROPN
dti-1336	180	13	stefano	stefano	PROPN
dti-1336	180	14	,	,	PUNCT
dti-1336	180	15	v.	v.	PROPN
dti-1336	180	16	,	,	PUNCT
dti-1336	180	17	taioli	taioli	PROPN
dti-1336	180	18	,	,	PUNCT
dti-1336	180	19	e.	e.	PROPN
dti-1336	180	20	,	,	PUNCT
dti-1336	180	21	rossi	rossi	ADJ
dti-1336	180	22	,	,	PUNCT
dti-1336	180	23	v.	v.	PROPN
dti-1336	180	24	,	,	PUNCT
dti-1336	180	25	crosti	crosti	PROPN
dti-1336	180	26	,	,	PUNCT
dti-1336	180	27	f.	f.	PROPN
dti-1336	180	28	,	,	PUNCT
dti-1336	180	29	paciaroni	paciaroni	NOUN
dti-1336	180	30	,	,	PUNCT
dti-1336	180	31	k.	k.	PROPN
dti-1336	180	32	,	,	PUNCT
dti-1336	180	33	leone	leone	PROPN
dti-1336	180	34	,	,	PUNCT
dti-1336	180	35	g.	g.	PROPN
dti-1336	180	36	and	and	CCONJ
dti-1336	180	37	faioni	faioni	PROPN
dti-1336	180	38	,	,	PUNCT
dti-1336	180	39	e.m	e.m	PROPN
dti-1336	180	40	.	.	PROPN
dti-1336	180	41	1998	1998	NUM
dti-1336	180	42	.	.	PUNCT
dti-1336	181	1	different	different	ADJ
dti-1336	181	2	risks	risk	NOUN
dti-1336	181	3	of	of	ADP
dti-1336	181	4	thrombosis	thrombosis	NOUN
dti-1336	181	5	in	in	ADP
dti-1336	181	6	four	four	NUM
dti-1336	181	7	coagulation	coagulation	NOUN
dti-1336	181	8	defects	defect	NOUN
dti-1336	181	9	associated	associate	VERB
dti-1336	181	10	with	with	ADP
dti-1336	181	11	inherited	inherited	ADJ
dti-1336	181	12	thrombophilia	thrombophilia	NOUN
dti-1336	181	13	:	:	PUNCT
dti-1336	181	14	a	a	DET
dti-1336	181	15	study	study	NOUN
dti-1336	181	16	of	of	ADP
dti-1336	181	17	150	150	NUM
dti-1336	181	18	families	family	NOUN
dti-1336	181	19	.	.	PUNCT
dti-1336	182	1	blood	blood	NOUN
dti-1336	182	2	,	,	PUNCT
dti-1336	182	3	92(7):2353–8	92(7):2353–8	NOUN
dti-1336	182	4	.	.	PUNCT
dti-1336	183	1	[	[	X
dti-1336	183	2	9	9	NUM
dti-1336	183	3	]	]	X
dti-1336	183	4	thaler	thaler	NOUN
dti-1336	183	5	,	,	PUNCT
dti-1336	183	6	e.	e.	PROPN
dti-1336	183	7	and	and	CCONJ
dti-1336	183	8	lechner	lechner	PROPN
dti-1336	183	9	,	,	PUNCT
dti-1336	183	10	k.	k.	PROPN
dti-1336	183	11	1981	1981	NUM
dti-1336	183	12	.	.	PUNCT
dti-1336	184	1	antithrombin	antithrombin	PROPN
dti-1336	184	2	iii	iii	PROPN
dti-1336	184	3	defi	defi	PROPN
dti-1336	184	4	ciency	ciency	NOUN
dti-1336	184	5	and	and	CCONJ
dti-1336	184	6	thromboembolism	thromboembolism	NOUN
dti-1336	184	7	.	.	PUNCT
dti-1336	185	1	clin	clin	PROPN
dti-1336	185	2	.	.	PUNCT
dti-1336	186	1	haematol	haematol	PROPN
dti-1336	186	2	.	.	PUNCT
dti-1336	186	3	,	,	PUNCT
dti-1336	186	4	10:369	10:369	NUM
dti-1336	186	5	.	.	PUNCT
dti-1336	187	1	[	[	X
dti-1336	187	2	10	10	NUM
dti-1336	187	3	]	]	X
dti-1336	187	4	broekmans	broekmans	PROPN
dti-1336	187	5	,	,	PUNCT
dti-1336	187	6	a.w	a.w	PROPN
dti-1336	187	7	.	.	PROPN
dti-1336	187	8	and	and	CCONJ
dti-1336	187	9	bertina	bertina	PROPN
dti-1336	187	10	,	,	PUNCT
dti-1336	187	11	r.m	r.m	PROPN
dti-1336	187	12	.	.	PROPN
dti-1336	187	13	1985	1985	NUM
dti-1336	187	14	.	.	PUNCT
dti-1336	188	1	in	in	ADP
dti-1336	188	2	poller	poller	PROPN
dti-1336	188	3	l	l	PROPN
dti-1336	188	4	(	(	PUNCT
dti-1336	188	5	ed	ed	NOUN
dti-1336	188	6	):	):	PUNCT
dti-1336	188	7	recent	recent	ADJ
dti-1336	188	8	advances	advance	NOUN
dti-1336	188	9	in	in	ADP
dti-1336	188	10	blood	blood	NOUN
dti-1336	188	11	coagulation	coagulation	NOUN
dti-1336	188	12	.	.	PUNCT
dti-1336	189	1	new	new	PROPN
dti-1336	189	2	york	york	PROPN
dti-1336	189	3	,	,	PUNCT
dti-1336	189	4	churchikk	churchikk	PROPN
dti-1336	189	5	livingstone117	livingstone117	PROPN
dti-1336	189	6	.	.	PUNCT
dti-1336	190	1	[	[	X
dti-1336	190	2	11	11	NUM
dti-1336	190	3	]	]	SYM
dti-1336	190	4	lechner	lechner	NOUN
dti-1336	190	5	,	,	PUNCT
dti-1336	190	6	k.	k.	PROPN
dti-1336	190	7	and	and	CCONJ
dti-1336	190	8	kyrle	kyrle	PROPN
dti-1336	190	9	,	,	PUNCT
dti-1336	190	10	p.a	p.a	PROPN
dti-1336	190	11	.	.	PROPN
dti-1336	190	12	1995	1995	NUM
dti-1336	190	13	mar	mar	PROPN
dti-1336	190	14	.	.	PROPN
dti-1336	190	15	antithrombin	antithrombin	PROPN
dti-1336	190	16	iii	iii	PROPN
dti-1336	190	17	concentrates	concentrate	NOUN
dti-1336	190	18	are	be	AUX
dti-1336	190	19	they	they	PRON
dti-1336	190	20	clinically	clinically	ADV
dti-1336	190	21	useful	useful	ADJ
dti-1336	190	22	?	?	PUNCT
dti-1336	191	1	thromb	thromb	NOUN
dti-1336	191	2	.	.	PUNCT
dti-1336	192	1	haemost	haemost	PROPN
dti-1336	192	2	.	.	PUNCT
dti-1336	192	3	,	,	PUNCT
dti-1336	193	1	73(3):340–8	73(3):340–8	X
dti-1336	193	2	.	.	PUNCT
dti-1336	194	1	[	[	X
dti-1336	194	2	12	12	NUM
dti-1336	194	3	]	]	PUNCT
dti-1336	194	4	reitsma	reitsma	NOUN
dti-1336	194	5	,	,	PUNCT
dti-1336	194	6	p.h	p.h	PROPN
dti-1336	194	7	.	.	PROPN
dti-1336	194	8	,	,	PUNCT
dti-1336	194	9	bernardi	bernardi	PROPN
dti-1336	194	10	,	,	PUNCT
dti-1336	194	11	f.	f.	PROPN
dti-1336	194	12	,	,	PUNCT
dti-1336	194	13	doig	doig	PROPN
dti-1336	194	14	,	,	PUNCT
dti-1336	194	15	r.g	r.g	PROPN
dti-1336	194	16	.	.	PROPN
dti-1336	194	17	,	,	PUNCT
dti-1336	194	18	gandrille	gandrille	PROPN
dti-1336	194	19	,	,	PUNCT
dti-1336	194	20	s.	s.	PROPN
dti-1336	194	21	,	,	PUNCT
dti-1336	194	22	greengard	greengard	NOUN
dti-1336	194	23	,	,	PUNCT
dti-1336	194	24	j.s	j.s	PROPN
dti-1336	194	25	.	.	PROPN
dti-1336	194	26	,	,	PUNCT
dti-1336	194	27	ireland	ireland	PROPN
dti-1336	194	28	,	,	PUNCT
dti-1336	194	29	h.	h.	PROPN
dti-1336	194	30	,	,	PUNCT
dti-1336	194	31	krawczak	krawczak	PROPN
dti-1336	194	32	,	,	PUNCT
dti-1336	194	33	m.	m.	NOUN
dti-1336	194	34	,	,	PUNCT
dti-1336	194	35	lind	lind	PROPN
dti-1336	194	36	,	,	PUNCT
dti-1336	194	37	b.	b.	PROPN
dti-1336	194	38	,	,	PUNCT
dti-1336	194	39	long	long	ADV
dti-1336	194	40	,	,	PUNCT
dti-1336	194	41	g.l	g.l	PROPN
dti-1336	194	42	.	.	PROPN
dti-1336	194	43	,	,	PUNCT
dti-1336	194	44	poort	poort	PROPN
dti-1336	194	45	,	,	PUNCT
dti-1336	194	46	s.r	s.r	PROPN
dti-1336	194	47	.	.	PROPN
dti-1336	194	48	et	et	PROPN
dti-1336	194	49	al	al	PROPN
dti-1336	194	50	.	.	PROPN
dti-1336	194	51	1995	1995	NUM
dti-1336	194	52	may	may	AUX
dti-1336	194	53	.	.	PUNCT
dti-1336	195	1	protein	protein	NOUN
dti-1336	195	2	c	c	PROPN
dti-1336	195	3	defi	defi	PROPN
dti-1336	195	4	ciency	ciency	NOUN
dti-1336	195	5	:	:	PUNCT
dti-1336	195	6	a	a	DET
dti-1336	195	7	database	database	NOUN
dti-1336	195	8	of	of	ADP
dti-1336	195	9	mutations	mutation	NOUN
dti-1336	195	10	,	,	PUNCT
dti-1336	195	11	1995	1995	NUM
dti-1336	195	12	update	update	NOUN
dti-1336	195	13	.	.	PUNCT
dti-1336	196	1	on	on	ADP
dti-1336	196	2	behalf	behalf	NOUN
dti-1336	196	3	of	of	ADP
dti-1336	196	4	the	the	DET
dti-1336	196	5	subcommittee	subcommittee	NOUN
dti-1336	196	6	on	on	ADP
dti-1336	196	7	plasma	plasma	NOUN
dti-1336	196	8	coagulation	coagulation	NOUN
dti-1336	196	9	inhibitors	inhibitor	NOUN
dti-1336	196	10	of	of	ADP
dti-1336	196	11	the	the	DET
dti-1336	196	12	scientifi	scientifi	NOUN
dti-1336	196	13	c	c	PROPN
dti-1336	196	14	and	and	CCONJ
dti-1336	196	15	standardization	standardization	NOUN
dti-1336	196	16	committee	committee	NOUN
dti-1336	196	17	of	of	ADP
dti-1336	196	18	the	the	DET
dti-1336	196	19	isth	isth	NOUN
dti-1336	196	20	.	.	PUNCT
dti-1336	196	21	thromb	thromb	PROPN
dti-1336	196	22	.	.	PUNCT
dti-1336	197	1	haemost	haemost	VERB
dti-1336	197	2	,	,	PUNCT
dti-1336	197	3	73(5):876–89	73(5):876–89	NUM
dti-1336	197	4	.	.	PUNCT
dti-1336	198	1	[	[	X
dti-1336	198	2	13	13	NUM
dti-1336	198	3	]	]	X
dti-1336	198	4	mcgehee	mcgehee	PROPN
dti-1336	198	5	,	,	PUNCT
dti-1336	198	6	w.g	w.g	PROPN
dti-1336	198	7	.	.	PROPN
dti-1336	198	8	,	,	PUNCT
dti-1336	198	9	klotz	klotz	PROPN
dti-1336	198	10	,	,	PUNCT
dti-1336	198	11	t.a	t.a	PROPN
dti-1336	198	12	.	.	PROPN
dti-1336	198	13	,	,	PUNCT
dti-1336	198	14	epstein	epstein	PROPN
dti-1336	198	15	,	,	PUNCT
dti-1336	198	16	d.j	d.j	PROPN
dti-1336	198	17	.	.	PROPN
dti-1336	198	18	and	and	CCONJ
dti-1336	198	19	rapaport	rapaport	PROPN
dti-1336	198	20	,	,	PUNCT
dti-1336	198	21	s.i	s.i	PROPN
dti-1336	198	22	.	.	PROPN
dti-1336	198	23	1984	1984	NUM
dti-1336	199	1	jul	jul	PROPN
dti-1336	199	2	.	.	PUNCT
dti-1336	199	3	coumarin	coumarin	NOUN
dti-1336	199	4	necrosis	necrosis	NOUN
dti-1336	199	5	associated	associate	VERB
dti-1336	199	6	with	with	ADP
dti-1336	199	7	hereditary	hereditary	ADJ
dti-1336	199	8	protein	protein	NOUN
dti-1336	199	9	c	c	PROPN
dti-1336	199	10	defi	defi	NOUN
dti-1336	199	11	ciency	ciency	NOUN
dti-1336	199	12	.	.	PUNCT
dti-1336	200	1	ann	ann	PROPN
dti-1336	200	2	.	.	PUNCT
dti-1336	200	3	intern	intern	PROPN
dti-1336	200	4	.	.	PUNCT
dti-1336	201	1	med	med	PROPN
dti-1336	201	2	.	.	PROPN
dti-1336	201	3	,	,	PUNCT
dti-1336	201	4	101(1):59–60	101(1):59–60	NOUN
dti-1336	201	5	.	.	PUNCT
dti-1336	202	1	[	[	X
dti-1336	202	2	14	14	NUM
dti-1336	202	3	]	]	X
dti-1336	202	4	seligsohn	seligsohn	PROPN
dti-1336	202	5	,	,	PUNCT
dti-1336	202	6	u.	u.	PROPN
dti-1336	202	7	,	,	PUNCT
dti-1336	202	8	berger	berger	PROPN
dti-1336	202	9	,	,	PUNCT
dti-1336	202	10	a.	a.	PROPN
dti-1336	202	11	,	,	PUNCT
dti-1336	202	12	abend	abend	NOUN
dti-1336	202	13	,	,	PUNCT
dti-1336	202	14	m.	m.	NOUN
dti-1336	202	15	,	,	PUNCT
dti-1336	202	16	rubin	rubin	PROPN
dti-1336	202	17	,	,	PUNCT
dti-1336	202	18	l.	l.	PROPN
dti-1336	202	19	,	,	PUNCT
dti-1336	202	20	attias	attias	PROPN
dti-1336	202	21	,	,	PUNCT
dti-1336	202	22	d.	d.	PROPN
dti-1336	202	23	,	,	PUNCT
dti-1336	202	24	zivelin	zivelin	PROPN
dti-1336	202	25	,	,	PUNCT
dti-1336	202	26	a.	a.	NOUN
dti-1336	202	27	and	and	CCONJ
dti-1336	202	28	rapaport	rapaport	PROPN
dti-1336	202	29	,	,	PUNCT
dti-1336	203	1	s.i	s.i	PROPN
dti-1336	203	2	.	.	PROPN
dti-1336	203	3	1984	1984	NUM
dti-1336	203	4	mar	mar	PROPN
dti-1336	203	5	1	1	NUM
dti-1336	203	6	.	.	PUNCT
dti-1336	203	7	homozygous	homozygous	ADJ
dti-1336	203	8	protein	protein	NOUN
dti-1336	203	9	c	c	PROPN
dti-1336	203	10	defi	defi	NOUN
dti-1336	203	11	ciency	ciency	NOUN
dti-1336	203	12	manifested	manifest	VERB
dti-1336	203	13	by	by	ADP
dti-1336	203	14	massive	massive	ADJ
dti-1336	203	15	venous	venous	ADJ
dti-1336	203	16	thrombosis	thrombosis	NOUN
dti-1336	203	17	in	in	ADP
dti-1336	203	18	the	the	DET
dti-1336	203	19	newborn	newborn	ADJ
dti-1336	203	20	.	.	PUNCT
dti-1336	204	1	n.	n.	PROPN
dti-1336	204	2	engl	engl	PROPN
dti-1336	204	3	.	.	PUNCT
dti-1336	205	1	j.	j.	PROPN
dti-1336	205	2	med	med	PROPN
dti-1336	205	3	.	.	PROPN
dti-1336	205	4	,	,	PUNCT
dti-1336	205	5	310(9):559–62	310(9):559–62	NUM
dti-1336	205	6	.	.	PUNCT
dti-1336	206	1	96	96	NUM
dti-1336	206	2	zangari	zangari	PROPN
dti-1336	206	3	et	et	PROPN
dti-1336	206	4	al	al	PROPN
dti-1336	206	5	drug	drug	PROPN
dti-1336	206	6	target	target	NOUN
dti-1336	206	7	insights	insight	VERB
dti-1336	206	8	2008:3	2008:3	NUM
dti-1336	206	9	[	[	X
dti-1336	206	10	15	15	NUM
dti-1336	206	11	]	]	X
dti-1336	206	12	buchanan	buchanan	PROPN
dti-1336	206	13	,	,	PUNCT
dti-1336	206	14	g.r	g.r	PROPN
dti-1336	206	15	.	.	PROPN
dti-1336	206	16	and	and	CCONJ
dti-1336	206	17	holtkamp	holtkamp	PROPN
dti-1336	206	18	,	,	PUNCT
dti-1336	206	19	c.a	c.a	PROPN
dti-1336	206	20	.	.	PROPN
dti-1336	206	21	1980	1980	NUM
dti-1336	206	22	.	.	PUNCT
dti-1336	207	1	reduced	reduce	VERB
dti-1336	207	2	antithrombin	antithrombin	PROPN
dti-1336	207	3	iii	iii	PROPN
dti-1336	207	4	levels	level	NOUN
dti-1336	207	5	during	during	ADP
dti-1336	207	6	l	l	NOUN
dti-1336	207	7	-	-	ADJ
dti-1336	207	8	asparaginase	asparaginase	NOUN
dti-1336	207	9	therapy	therapy	NOUN
dti-1336	207	10	.	.	PUNCT
dti-1336	208	1	med	med	PROPN
dti-1336	208	2	.	.	PUNCT
dti-1336	209	1	pediatr	pediatr	PROPN
dti-1336	209	2	.	.	PUNCT
dti-1336	210	1	oncol	oncol	PROPN
dti-1336	210	2	.	.	PUNCT
dti-1336	210	3	,	,	PUNCT
dti-1336	210	4	8:7	8:7	NUM
dti-1336	210	5	.	.	PUNCT
dti-1336	211	1	[	[	X
dti-1336	211	2	16	16	NUM
dti-1336	211	3	]	]	X
dti-1336	211	4	wall	wall	NOUN
dti-1336	211	5	,	,	PUNCT
dti-1336	211	6	g.	g.	PROPN
dti-1336	211	7	,	,	PUNCT
dti-1336	211	8	weiss	weiss	PROPN
dti-1336	211	9	,	,	PUNCT
dti-1336	211	10	r.b	r.b	PROPN
dti-1336	211	11	.	.	PROPN
dti-1336	211	12	,	,	PUNCT
dti-1336	211	13	norton	norton	PROPN
dti-1336	211	14	,	,	PUNCT
dti-1336	211	15	l.	l.	PROPN
dti-1336	211	16	et	et	PROPN
dti-1336	211	17	al	al	PROPN
dti-1336	211	18	.	.	PROPN
dti-1336	211	19	1989	1989	NUM
dti-1336	211	20	.	.	PUNCT
dti-1336	212	1	arterial	arterial	ADJ
dti-1336	212	2	thrombosis	thrombosis	NOUN
dti-1336	212	3	associated	associate	VERB
dti-1336	212	4	with	with	ADP
dti-1336	212	5	adjuvant	adjuvant	ADJ
dti-1336	212	6	chemotherapy	chemotherapy	NOUN
dti-1336	212	7	for	for	ADP
dti-1336	212	8	breast	breast	NOUN
dti-1336	212	9	carcinoma	carcinoma	NOUN
dti-1336	212	10	:	:	PUNCT
dti-1336	212	11	a	a	DET
dti-1336	212	12	cancer	cancer	NOUN
dti-1336	212	13	and	and	CCONJ
dti-1336	212	14	leukaemia	leukaemia	PROPN
dti-1336	212	15	group	group	NOUN
dti-1336	212	16	b.	b.	PROPN
dti-1336	212	17	study	study	PROPN
dti-1336	212	18	.	.	PUNCT
dti-1336	213	1	am	be	AUX
dti-1336	213	2	.	.	PUNCT
dti-1336	214	1	j.	j.	PROPN
dti-1336	214	2	med	med	PROPN
dti-1336	214	3	.	.	PROPN
dti-1336	214	4	,	,	PUNCT
dti-1336	214	5	87:501	87:501	NUM
dti-1336	214	6	.	.	PUNCT
dti-1336	215	1	[	[	X
dti-1336	215	2	17	17	NUM
dti-1336	215	3	]	]	SYM
dti-1336	215	4	feffer	feffer	NOUN
dti-1336	215	5	,	,	PUNCT
dti-1336	215	6	s.e	s.e	PROPN
dti-1336	215	7	.	.	PROPN
dti-1336	215	8	,	,	PUNCT
dti-1336	215	9	carmosino	carmosino	NOUN
dti-1336	215	10	,	,	PUNCT
dti-1336	215	11	l.s	l.s	PROPN
dti-1336	215	12	.	.	PROPN
dti-1336	215	13	and	and	CCONJ
dti-1336	215	14	fox	fox	PROPN
dti-1336	215	15	,	,	PUNCT
dti-1336	215	16	r.l	r.l	PROPN
dti-1336	215	17	.	.	PROPN
dti-1336	215	18	1989	1989	NUM
dti-1336	215	19	.	.	PUNCT
dti-1336	216	1	acquired	acquire	VERB
dti-1336	216	2	protein	protein	NOUN
dti-1336	216	3	c	c	PROPN
dti-1336	216	4	defi	defi	NOUN
dti-1336	216	5	ciency	ciency	NOUN
dti-1336	216	6	in	in	ADP
dti-1336	216	7	patients	patient	NOUN
dti-1336	216	8	with	with	ADP
dti-1336	216	9	breast	breast	NOUN
dti-1336	216	10	cancer	cancer	NOUN
dti-1336	216	11	receiving	receive	VERB
dti-1336	216	12	cyclophosphamide	cyclophosphamide	NOUN
dti-1336	216	13	,	,	PUNCT
dti-1336	216	14	methotrexate	methotrexate	NOUN
dti-1336	216	15	,	,	PUNCT
dti-1336	216	16	and	and	CCONJ
dti-1336	216	17	5	5	NUM
dti-1336	216	18	-	-	PUNCT
dti-1336	216	19	fl	fl	NUM
dti-1336	216	20	uorouracil	uorouracil	PROPN
dti-1336	216	21	.	.	PUNCT
dti-1336	217	1	cancer	cancer	NOUN
dti-1336	217	2	,	,	PUNCT
dti-1336	217	3	63:1303	63:1303	NUM
dti-1336	217	4	.	.	PUNCT
dti-1336	218	1	[	[	X
dti-1336	218	2	18	18	NUM
dti-1336	218	3	]	]	X
dti-1336	218	4	comp	comp	X
dti-1336	218	5	,	,	PUNCT
dti-1336	218	6	p.c	p.c	PROPN
dti-1336	218	7	.	.	PROPN
dti-1336	218	8	,	,	PUNCT
dti-1336	218	9	nixon	nixon	PROPN
dti-1336	218	10	,	,	PUNCT
dti-1336	218	11	r.r	r.r	PROPN
dti-1336	218	12	.	.	PROPN
dti-1336	218	13	,	,	PUNCT
dti-1336	218	14	cooper	cooper	PROPN
dti-1336	218	15	,	,	PUNCT
dti-1336	218	16	m.r	m.r	PROPN
dti-1336	218	17	.	.	PROPN
dti-1336	218	18	and	and	CCONJ
dti-1336	218	19	esmon	esmon	PROPN
dti-1336	218	20	,	,	PUNCT
dti-1336	218	21	c.t	c.t	PROPN
dti-1336	218	22	.	.	PROPN
dti-1336	218	23	1984	1984	NUM
dti-1336	218	24	.	.	PUNCT
dti-1336	219	1	familial	familial	ADJ
dti-1336	219	2	protein	protein	NOUN
dti-1336	219	3	s	s	PART
dti-1336	219	4	defi	defi	NOUN
dti-1336	219	5	ciency	ciency	NOUN
dti-1336	219	6	is	be	AUX
dti-1336	219	7	associated	associate	VERB
dti-1336	219	8	with	with	ADP
dti-1336	219	9	recurrent	recurrent	ADJ
dti-1336	219	10	thrombosis	thrombosis	NOUN
dti-1336	219	11	.	.	PUNCT
dti-1336	220	1	j.	j.	PROPN
dti-1336	220	2	clin	clin	PROPN
dti-1336	220	3	.	.	PUNCT
dti-1336	221	1	invest	invest	PROPN
dti-1336	221	2	.	.	PUNCT
dti-1336	221	3	,	,	PUNCT
dti-1336	221	4	74:2082–8	74:2082–8	X
dti-1336	221	5	.	.	PUNCT
dti-1336	222	1	[	[	X
dti-1336	222	2	19	19	NUM
dti-1336	222	3	]	]	X
dti-1336	222	4	esmon	esmon	PROPN
dti-1336	222	5	,	,	PUNCT
dti-1336	222	6	c.t	c.t	PROPN
dti-1336	222	7	.	.	PROPN
dti-1336	222	8	,	,	PUNCT
dti-1336	222	9	esmon	esmon	PROPN
dti-1336	222	10	,	,	PUNCT
dti-1336	222	11	n.l	n.l	PROPN
dti-1336	222	12	.	.	PROPN
dti-1336	222	13	and	and	CCONJ
dti-1336	222	14	protein	protein	NOUN
dti-1336	222	15	,	,	PUNCT
dti-1336	222	16	c.	c.	PROPN
dti-1336	222	17	1984	1984	NUM
dti-1336	222	18	apr	apr	NOUN
dti-1336	222	19	.	.	PUNCT
dti-1336	222	20	activation	activation	NOUN
dti-1336	222	21	.	.	PUNCT
dti-1336	223	1	semin	semin	PROPN
dti-1336	223	2	.	.	PUNCT
dti-1336	224	1	thromb	thromb	PROPN
dti-1336	224	2	.	.	PUNCT
dti-1336	225	1	hemost	hemost	PROPN
dti-1336	225	2	.	.	PUNCT
dti-1336	226	1	,	,	PUNCT
dti-1336	226	2	10(2):122–30	10(2):122–30	NUM
dti-1336	226	3	.	.	PUNCT
dti-1336	227	1	[	[	X
dti-1336	227	2	20	20	NUM
dti-1336	227	3	]	]	X
dti-1336	227	4	maurissen	maurissen	NOUN
dti-1336	227	5	lf	lf	PROPN
dti-1336	227	6	,	,	PUNCT
dti-1336	227	7	thomassen	thomassen	PROPN
dti-1336	227	8	mc	mc	PROPN
dti-1336	227	9	,	,	PUNCT
dti-1336	227	10	nicolases	nicolases	PROPN
dti-1336	227	11	ga	ga	PROPN
dti-1336	227	12	,	,	PUNCT
dti-1336	227	13	dahlback	dahlback	PROPN
dti-1336	227	14	b	b	PROPN
dti-1336	227	15	,	,	PUNCT
dti-1336	227	16	rosing	rose	VERB
dti-1336	227	17	j	j	PROPN
dti-1336	227	18	,	,	PUNCT
dti-1336	227	19	hackeng	hackeng	PROPN
dti-1336	227	20	tm	tm	PROPN
dti-1336	227	21	.	.	PROPN
dti-1336	227	22	2008	2008	NUM
dti-1336	227	23	mar	mar	PROPN
dti-1336	227	24	15	15	NUM
dti-1336	227	25	.	.	PUNCT
dti-1336	227	26	re	re	NOUN
dti-1336	227	27	-	-	NOUN
dti-1336	227	28	evaluation	evaluation	NOUN
dti-1336	227	29	of	of	ADP
dti-1336	227	30	the	the	DET
dti-1336	227	31	role	role	NOUN
dti-1336	227	32	of	of	ADP
dti-1336	227	33	the	the	DET
dti-1336	227	34	protein	protein	NOUN
dti-1336	227	35	s	s	NOUN
dti-1336	227	36	-	-	PUNCT
dti-1336	227	37	c4b	c4b	ADJ
dti-1336	227	38	binding	bind	VERB
dti-1336	227	39	protein	protein	NOUN
dti-1336	227	40	complex	complex	NOUN
dti-1336	227	41	in	in	ADP
dti-1336	227	42	activated	activate	VERB
dti-1336	227	43	protein	protein	NOUN
dti-1336	227	44	c	c	NOUN
dti-1336	227	45	-	-	PUNCT
dti-1336	227	46	catalyzed	catalyze	VERB
dti-1336	227	47	vainactivation	vainactivation	NOUN
dti-1336	227	48	.	.	PUNCT
dti-1336	228	1	blood	blood	NOUN
dti-1336	228	2	,	,	PUNCT
dti-1336	228	3	111(6):3043–41	111(6):3043–41	NOUN
dti-1336	228	4	.	.	PUNCT
dti-1336	229	1	[	[	X
dti-1336	229	2	21	21	NUM
dti-1336	229	3	]	]	PUNCT
dti-1336	229	4	d’angelo	d’angelo	PROPN
dti-1336	229	5	,	,	PUNCT
dti-1336	229	6	a.	a.	NOUN
dti-1336	229	7	,	,	PUNCT
dti-1336	229	8	vigano	vigano	NOUN
dti-1336	229	9	-	-	PUNCT
dti-1336	229	10	d’angelo	d’angelo	PROPN
dti-1336	229	11	,	,	PUNCT
dti-1336	229	12	s.	s.	PROPN
dti-1336	229	13	,	,	PUNCT
dti-1336	229	14	esmon	esmon	PROPN
dti-1336	229	15	,	,	PUNCT
dti-1336	229	16	c.t	c.t	PROPN
dti-1336	229	17	.	.	PROPN
dti-1336	229	18	and	and	CCONJ
dti-1336	229	19	comp	comp	PROPN
dti-1336	229	20	,	,	PUNCT
dti-1336	229	21	p.c	p.c	PROPN
dti-1336	229	22	.	.	PROPN
dti-1336	229	23	1988	1988	NUM
dti-1336	229	24	may	may	AUX
dti-1336	229	25	.	.	PUNCT
dti-1336	230	1	acquired	acquire	VERB
dti-1336	230	2	defi	defi	NOUN
dti-1336	230	3	ciencies	ciencie	NOUN
dti-1336	230	4	of	of	ADP
dti-1336	230	5	protein	protein	NOUN
dti-1336	230	6	s.	s.	PROPN
dti-1336	230	7	protein	protein	NOUN
dti-1336	230	8	s	s	PART
dti-1336	230	9	activity	activity	NOUN
dti-1336	230	10	during	during	ADP
dti-1336	230	11	oral	oral	ADJ
dti-1336	230	12	anticoagulation	anticoagulation	NOUN
dti-1336	230	13	,	,	PUNCT
dti-1336	230	14	in	in	ADP
dti-1336	230	15	liver	liver	NOUN
dti-1336	230	16	disease	disease	NOUN
dti-1336	230	17	,	,	PUNCT
dti-1336	230	18	and	and	CCONJ
dti-1336	230	19	in	in	ADP
dti-1336	230	20	disseminated	disseminate	VERB
dti-1336	230	21	intravascular	intravascular	ADJ
dti-1336	230	22	coagulation	coagulation	NOUN
dti-1336	230	23	.	.	PUNCT
dti-1336	231	1	j.	j.	PROPN
dti-1336	231	2	clin	clin	PROPN
dti-1336	231	3	.	.	PUNCT
dti-1336	232	1	invest	invest	PROPN
dti-1336	232	2	.	.	PUNCT
dti-1336	232	3	,	,	PUNCT
dti-1336	232	4	81(5):1445–54	81(5):1445–54	X
dti-1336	232	5	.	.	PUNCT
dti-1336	233	1	[	[	X
dti-1336	233	2	22	22	NUM
dti-1336	233	3	]	]	X
dti-1336	233	4	rezende	rezende	PROPN
dti-1336	233	5	,	,	PUNCT
dti-1336	233	6	s.m	s.m	PROPN
dti-1336	233	7	.	.	PROPN
dti-1336	233	8	,	,	PUNCT
dti-1336	233	9	simmonds	simmonds	PROPN
dti-1336	233	10	,	,	PUNCT
dti-1336	233	11	r.e	r.e	PROPN
dti-1336	233	12	.	.	PROPN
dti-1336	233	13	and	and	CCONJ
dti-1336	233	14	lane	lane	NOUN
dti-1336	233	15	,	,	PUNCT
dti-1336	233	16	d.a	d.a	PROPN
dti-1336	233	17	.	.	PROPN
dti-1336	233	18	2004	2004	NUM
dti-1336	233	19	feb	feb	NOUN
dti-1336	233	20	15	15	NUM
dti-1336	233	21	.	.	PUNCT
dti-1336	234	1	coagulation	coagulation	NOUN
dti-1336	234	2	,	,	PUNCT
dti-1336	234	3	infl	infl	PROPN
dti-1336	234	4	ammation	ammation	NOUN
dti-1336	234	5	,	,	PUNCT
dti-1336	234	6	and	and	CCONJ
dti-1336	234	7	apoptosis	apoptosis	NOUN
dti-1336	234	8	:	:	PUNCT
dti-1336	234	9	different	different	ADJ
dti-1336	234	10	roles	role	NOUN
dti-1336	234	11	for	for	ADP
dti-1336	234	12	protein	protein	NOUN
dti-1336	234	13	s	s	NOUN
dti-1336	234	14	and	and	CCONJ
dti-1336	234	15	the	the	DET
dti-1336	234	16	protein	protein	NOUN
dti-1336	234	17	s	s	NOUN
dti-1336	234	18	-	-	PUNCT
dti-1336	234	19	c4b	c4b	ADJ
dti-1336	234	20	binding	bind	VERB
dti-1336	234	21	protein	protein	NOUN
dti-1336	234	22	complex	complex	NOUN
dti-1336	234	23	.	.	PUNCT
dti-1336	235	1	blood	blood	NOUN
dti-1336	235	2	,	,	PUNCT
dti-1336	235	3	103(4):1192–201	103(4):1192–201	NUM
dti-1336	235	4	allaartaronsonruys1990	allaartaronsonruys1990	NOUN
dti-1336	235	5	.	.	PUNCT
dti-1336	236	1	[	[	X
dti-1336	236	2	23	23	NUM
dti-1336	236	3	]	]	X
dti-1336	236	4	dahlback	dahlback	PROPN
dti-1336	236	5	,	,	PUNCT
dti-1336	236	6	b.	b.	PROPN
dti-1336	236	7	,	,	PUNCT
dti-1336	236	8	carlsson	carlsson	PROPN
dti-1336	236	9	,	,	PUNCT
dti-1336	236	10	m.	m.	NOUN
dti-1336	236	11	and	and	CCONJ
dti-1336	236	12	svensson	svensson	PROPN
dti-1336	236	13	,	,	PUNCT
dti-1336	236	14	p.j	p.j	PROPN
dti-1336	236	15	.	.	PROPN
dti-1336	236	16	1993	1993	NUM
dti-1336	236	17	.	.	PUNCT
dti-1336	237	1	familial	familial	ADJ
dti-1336	237	2	thrombophilia	thrombophilia	NOUN
dti-1336	237	3	due	due	ADP
dti-1336	237	4	to	to	ADP
dti-1336	237	5	a	a	DET
dti-1336	237	6	previously	previously	ADV
dti-1336	237	7	unrecognized	unrecognize	VERB
dti-1336	237	8	mechanism	mechanism	NOUN
dti-1336	237	9	characterized	characterize	VERB
dti-1336	237	10	by	by	ADP
dti-1336	237	11	poor	poor	ADJ
dti-1336	237	12	anticoagulant	anticoagulant	ADJ
dti-1336	237	13	response	response	NOUN
dti-1336	237	14	to	to	ADP
dti-1336	237	15	activated	activate	VERB
dti-1336	237	16	protein	protein	NOUN
dti-1336	237	17	c	c	NOUN
dti-1336	237	18	:	:	PUNCT
dti-1336	237	19	prediction	prediction	NOUN
dti-1336	237	20	of	of	ADP
dti-1336	237	21	a	a	DET
dti-1336	237	22	cofactor	cofactor	NOUN
dti-1336	237	23	to	to	ADP
dti-1336	237	24	activated	activate	VERB
dti-1336	237	25	protein	protein	NOUN
dti-1336	237	26	c.	c.	PROPN
dti-1336	237	27	proc	proc	PROPN
dti-1336	237	28	.	.	PUNCT
dti-1336	238	1	natl	natl	PROPN
dti-1336	238	2	.	.	PUNCT
dti-1336	239	1	acad	acad	PROPN
dti-1336	239	2	.	.	PUNCT
dti-1336	240	1	sci	sci	PROPN
dti-1336	240	2	.	.	PUNCT
dti-1336	240	3	u.s.a	u.s.a	PROPN
dti-1336	240	4	.	.	PROPN
dti-1336	240	5	,	,	PUNCT
dti-1336	240	6	90(3):1004–8	90(3):1004–8	NUM
dti-1336	240	7	.	.	PUNCT
dti-1336	241	1	[	[	X
dti-1336	241	2	24	24	NUM
dti-1336	241	3	]	]	X
dti-1336	241	4	bertina	bertina	NOUN
dti-1336	241	5	,	,	PUNCT
dti-1336	241	6	r.m	r.m	PROPN
dti-1336	241	7	.	.	PROPN
dti-1336	241	8	,	,	PUNCT
dti-1336	241	9	koeleman	koeleman	PROPN
dti-1336	241	10	,	,	PUNCT
dti-1336	241	11	b.p	b.p	PROPN
dti-1336	241	12	.	.	PROPN
dti-1336	241	13	,	,	PUNCT
dti-1336	241	14	koster	koster	PROPN
dti-1336	241	15	,	,	PUNCT
dti-1336	241	16	t.	t.	PROPN
dti-1336	241	17	,	,	PUNCT
dti-1336	241	18	rosendaal	rosendaal	PROPN
dti-1336	241	19	,	,	PUNCT
dti-1336	241	20	f.r	f.r	PROPN
dti-1336	241	21	.	.	PROPN
dti-1336	241	22	,	,	PUNCT
dti-1336	241	23	dirven	dirven	NOUN
dti-1336	241	24	,	,	PUNCT
dti-1336	241	25	r.j	r.j	PROPN
dti-1336	241	26	.	.	PROPN
dti-1336	241	27	,	,	PUNCT
dti-1336	241	28	de	de	X
dti-1336	241	29	ronde	ronde	X
dti-1336	241	30	,	,	PUNCT
dti-1336	241	31	h.	h.	PROPN
dti-1336	241	32	,	,	PUNCT
dti-1336	241	33	van	van	PROPN
dti-1336	241	34	der	der	PROPN
dti-1336	241	35	velden	velden	PROPN
dti-1336	241	36	,	,	PUNCT
dti-1336	241	37	p.a	p.a	PROPN
dti-1336	241	38	.	.	PROPN
dti-1336	241	39	and	and	CCONJ
dti-1336	241	40	reitsma	reitsma	PROPN
dti-1336	241	41	,	,	PUNCT
dti-1336	241	42	p.h	p.h	PROPN
dti-1336	241	43	.	.	PROPN
dti-1336	241	44	1994	1994	NUM
dti-1336	241	45	.	.	PUNCT
dti-1336	242	1	mutation	mutation	NOUN
dti-1336	242	2	in	in	ADP
dti-1336	242	3	blood	blood	NOUN
dti-1336	242	4	coagulation	coagulation	NOUN
dti-1336	242	5	factor	factor	NOUN
dti-1336	242	6	v	v	NOUN
dti-1336	242	7	associated	associate	VERB
dti-1336	242	8	with	with	ADP
dti-1336	242	9	resistance	resistance	NOUN
dti-1336	242	10	to	to	ADP
dti-1336	242	11	activated	activate	VERB
dti-1336	242	12	protein	protein	NOUN
dti-1336	242	13	c.	c.	NOUN
dti-1336	242	14	nature	nature	NOUN
dti-1336	242	15	,	,	PUNCT
dti-1336	242	16	369(6475):64–7	369(6475):64–7	NUM
dti-1336	242	17	.	.	PUNCT
dti-1336	243	1	[	[	X
dti-1336	243	2	25	25	NUM
dti-1336	243	3	]	]	X
dti-1336	243	4	rees	rees	PROPN
dti-1336	243	5	,	,	PUNCT
dti-1336	243	6	d.c	d.c	PROPN
dti-1336	243	7	.	.	PROPN
dti-1336	243	8	,	,	PUNCT
dti-1336	243	9	cox	cox	PROPN
dti-1336	243	10	,	,	PUNCT
dti-1336	243	11	m.	m.	NOUN
dti-1336	243	12	and	and	CCONJ
dti-1336	243	13	clegg	clegg	PROPN
dti-1336	243	14	,	,	PUNCT
dti-1336	243	15	j.b	j.b	PROPN
dti-1336	243	16	.	.	PROPN
dti-1336	243	17	1995	1995	NUM
dti-1336	243	18	.	.	PUNCT
dti-1336	244	1	world	world	NOUN
dti-1336	244	2	distribution	distribution	NOUN
dti-1336	244	3	of	of	ADP
dti-1336	244	4	factor	factor	NOUN
dti-1336	244	5	v	v	PROPN
dti-1336	244	6	leiden	leiden	PROPN
dti-1336	244	7	.	.	PUNCT
dti-1336	245	1	lancet	lancet	PROPN
dti-1336	245	2	,	,	PUNCT
dti-1336	245	3	346(8983):1133–4	346(8983):1133–4	NUM
dti-1336	245	4	.	.	PUNCT
dti-1336	246	1	[	[	X
dti-1336	246	2	26	26	NUM
dti-1336	246	3	]	]	X
dti-1336	246	4	koster	koster	NOUN
dti-1336	246	5	,	,	PUNCT
dti-1336	246	6	t.	t.	PROPN
dti-1336	246	7	,	,	PUNCT
dti-1336	246	8	rosendaal	rosendaal	PROPN
dti-1336	246	9	,	,	PUNCT
dti-1336	246	10	f.r	f.r	PROPN
dti-1336	246	11	.	.	PROPN
dti-1336	246	12	,	,	PUNCT
dti-1336	246	13	de	de	X
dti-1336	246	14	ronde	ronde	X
dti-1336	246	15	,	,	PUNCT
dti-1336	246	16	h.	h.	PROPN
dti-1336	246	17	,	,	PUNCT
dti-1336	246	18	briet	briet	PROPN
dti-1336	246	19	,	,	PUNCT
dti-1336	246	20	e.	e.	PROPN
dti-1336	246	21	,	,	PUNCT
dti-1336	246	22	vandenbroucke	vandenbroucke	PROPN
dti-1336	246	23	,	,	PUNCT
dti-1336	246	24	j.p	j.p	PROPN
dti-1336	246	25	.	.	PROPN
dti-1336	246	26	and	and	CCONJ
dti-1336	246	27	bertina	bertina	PROPN
dti-1336	246	28	,	,	PUNCT
dti-1336	246	29	r.m	r.m	PROPN
dti-1336	246	30	.	.	PROPN
dti-1336	246	31	1993	1993	NUM
dti-1336	246	32	.	.	PUNCT
dti-1336	247	1	venous	venous	ADJ
dti-1336	247	2	thrombosis	thrombosis	NOUN
dti-1336	247	3	due	due	ADP
dti-1336	247	4	to	to	ADP
dti-1336	247	5	poor	poor	ADJ
dti-1336	247	6	anticoagulant	anticoagulant	ADJ
dti-1336	247	7	response	response	NOUN
dti-1336	247	8	to	to	ADP
dti-1336	247	9	activated	activate	VERB
dti-1336	247	10	protein	protein	NOUN
dti-1336	247	11	c	c	NOUN
dti-1336	247	12	:	:	PUNCT
dti-1336	247	13	leiden	leiden	PROPN
dti-1336	247	14	thrombophilia	thrombophilia	PROPN
dti-1336	247	15	study	study	PROPN
dti-1336	247	16	.	.	PUNCT
dti-1336	248	1	lancet	lancet	PROPN
dti-1336	248	2	,	,	PUNCT
dti-1336	248	3	342(8886–8887):1503–6	342(8886–8887):1503–6	NUM
dti-1336	248	4	.	.	PUNCT
dti-1336	249	1	[	[	X
dti-1336	249	2	27	27	NUM
dti-1336	249	3	]	]	SYM
dti-1336	249	4	rosendaal	rosendaal	NOUN
dti-1336	249	5	,	,	PUNCT
dti-1336	249	6	f.r	f.r	PROPN
dti-1336	249	7	.	.	PROPN
dti-1336	249	8	,	,	PUNCT
dti-1336	249	9	koster	koster	NOUN
dti-1336	249	10	,	,	PUNCT
dti-1336	249	11	t.	t.	PROPN
dti-1336	249	12	,	,	PUNCT
dti-1336	249	13	vandenbroucke	vandenbroucke	NOUN
dti-1336	249	14	,	,	PUNCT
dti-1336	249	15	j.p	j.p	PROPN
dti-1336	249	16	.	.	PROPN
dti-1336	249	17	and	and	CCONJ
dti-1336	249	18	reitsma	reitsma	PROPN
dti-1336	249	19	,	,	PUNCT
dti-1336	249	20	p.h	p.h	PROPN
dti-1336	249	21	.	.	PROPN
dti-1336	249	22	1995	1995	NUM
dti-1336	249	23	.	.	PUNCT
dti-1336	250	1	high	high	ADJ
dti-1336	250	2	risk	risk	NOUN
dti-1336	250	3	of	of	ADP
dti-1336	250	4	thrombosis	thrombosis	NOUN
dti-1336	250	5	in	in	ADP
dti-1336	250	6	patients	patient	NOUN
dti-1336	250	7	homozygous	homozygous	ADJ
dti-1336	250	8	for	for	ADP
dti-1336	250	9	factor	factor	NOUN
dti-1336	250	10	v	v	ADP
dti-1336	250	11	leiden	leiden	PROPN
dti-1336	250	12	(	(	PUNCT
dti-1336	250	13	activated	activate	VERB
dti-1336	250	14	protein	protein	NOUN
dti-1336	250	15	c	c	NOUN
dti-1336	250	16	resistance	resistance	NOUN
dti-1336	250	17	)	)	PUNCT
dti-1336	250	18	.	.	PUNCT
dti-1336	251	1	blood	blood	NOUN
dti-1336	251	2	,	,	PUNCT
dti-1336	251	3	85(6):1504–8	85(6):1504–8	NUM
dti-1336	251	4	.	.	PUNCT
dti-1336	252	1	[	[	X
dti-1336	252	2	28	28	NUM
dti-1336	252	3	]	]	X
dti-1336	252	4	vandenbroucke	vandenbroucke	NOUN
dti-1336	252	5	,	,	PUNCT
dti-1336	252	6	j.p	j.p	PROPN
dti-1336	252	7	.	.	PROPN
dti-1336	252	8	,	,	PUNCT
dti-1336	252	9	koster	koster	PROPN
dti-1336	252	10	,	,	PUNCT
dti-1336	252	11	t.	t.	PROPN
dti-1336	252	12	,	,	PUNCT
dti-1336	252	13	briët	briët	PROPN
dti-1336	252	14	,	,	PUNCT
dti-1336	252	15	e.	e.	PROPN
dti-1336	252	16	,	,	PUNCT
dti-1336	252	17	reitsma	reitsma	PROPN
dti-1336	252	18	,	,	PUNCT
dti-1336	252	19	p.h	p.h	PROPN
dti-1336	252	20	.	.	PROPN
dti-1336	252	21	,	,	PUNCT
dti-1336	252	22	bertina	bertina	PROPN
dti-1336	252	23	,	,	PUNCT
dti-1336	252	24	r.m	r.m	PROPN
dti-1336	252	25	.	.	PROPN
dti-1336	252	26	and	and	CCONJ
dti-1336	252	27	rosendaal	rosendaal	PROPN
dti-1336	252	28	,	,	PUNCT
dti-1336	252	29	f.r	f.r	PROPN
dti-1336	252	30	.	.	PROPN
dti-1336	252	31	1994	1994	NUM
dti-1336	252	32	.	.	PUNCT
dti-1336	253	1	increased	increase	VERB
dti-1336	253	2	risk	risk	NOUN
dti-1336	253	3	of	of	ADP
dti-1336	253	4	venous	venous	ADJ
dti-1336	253	5	thrombosis	thrombosis	NOUN
dti-1336	253	6	in	in	ADP
dti-1336	253	7	oral	oral	ADJ
dti-1336	253	8	-	-	PUNCT
dti-1336	253	9	contraceptive	contraceptive	NOUN
dti-1336	253	10	users	user	NOUN
dti-1336	253	11	who	who	PRON
dti-1336	253	12	are	be	AUX
dti-1336	253	13	carriers	carrier	NOUN
dti-1336	253	14	of	of	ADP
dti-1336	253	15	factor	factor	NOUN
dti-1336	253	16	v	v	PROPN
dti-1336	253	17	leiden	leiden	PROPN
dti-1336	253	18	mutation	mutation	PROPN
dti-1336	253	19	.	.	PUNCT
dti-1336	254	1	lancet	lancet	NOUN
dti-1336	254	2	,	,	PUNCT
dti-1336	254	3	344:1453–7	344:1453–7	NUM
dti-1336	254	4	.	.	PUNCT
dti-1336	255	1	[	[	X
dti-1336	255	2	29	29	NUM
dti-1336	255	3	]	]	X
dti-1336	255	4	rosendaal	rosendaal	NOUN
dti-1336	255	5	,	,	PUNCT
dti-1336	255	6	f.r	f.r	PROPN
dti-1336	255	7	.	.	PROPN
dti-1336	255	8	,	,	PUNCT
dti-1336	255	9	siscovick	siscovick	PROPN
dti-1336	255	10	,	,	PUNCT
dti-1336	255	11	d.s	d.s	PROPN
dti-1336	255	12	.	.	PROPN
dti-1336	255	13	,	,	PUNCT
dti-1336	255	14	schwartz	schwartz	PROPN
dti-1336	255	15	,	,	PUNCT
dti-1336	255	16	s.m	s.m	PROPN
dti-1336	255	17	.	.	PROPN
dti-1336	255	18	,	,	PUNCT
dti-1336	255	19	beverly	beverly	PROPN
dti-1336	255	20	,	,	PUNCT
dti-1336	255	21	r.k	r.k	PROPN
dti-1336	255	22	.	.	PROPN
dti-1336	255	23	,	,	PUNCT
dti-1336	255	24	psaty	psaty	PROPN
dti-1336	255	25	,	,	PUNCT
dti-1336	255	26	b.m	b.m	PROPN
dti-1336	255	27	.	.	PROPN
dti-1336	255	28	,	,	PUNCT
dti-1336	255	29	longstreth	longstreth	PROPN
dti-1336	255	30	,	,	PUNCT
dti-1336	255	31	w.t	w.t	PROPN
dti-1336	255	32	.	.	PROPN
dti-1336	255	33	jr	jr	PROPN
dti-1336	255	34	,	,	PUNCT
dti-1336	255	35	raghunathan	raghunathan	PROPN
dti-1336	255	36	,	,	PUNCT
dti-1336	255	37	t.e	t.e	PROPN
dti-1336	255	38	.	.	PROPN
dti-1336	255	39	,	,	PUNCT
dti-1336	255	40	koepsell	koepsell	PROPN
dti-1336	255	41	,	,	PUNCT
dti-1336	255	42	t.d	t.d	PROPN
dti-1336	255	43	.	.	PROPN
dti-1336	255	44	and	and	CCONJ
dti-1336	255	45	reitsma	reitsma	PROPN
dti-1336	255	46	,	,	PUNCT
dti-1336	255	47	p.h	p.h	PROPN
dti-1336	255	48	.	.	PROPN
dti-1336	255	49	1997	1997	NUM
dti-1336	255	50	apr	apr	NOUN
dti-1336	255	51	15	15	NUM
dti-1336	255	52	.	.	PUNCT
dti-1336	255	53	factor	factor	NOUN
dti-1336	255	54	v	v	PROPN
dti-1336	255	55	leiden	leiden	PROPN
dti-1336	255	56	(	(	PUNCT
dti-1336	255	57	resistance	resistance	NOUN
dti-1336	255	58	to	to	ADP
dti-1336	255	59	activated	activate	VERB
dti-1336	255	60	protein	protein	NOUN
dti-1336	255	61	c	c	NOUN
dti-1336	255	62	)	)	PUNCT
dti-1336	255	63	increases	increase	VERB
dti-1336	255	64	the	the	DET
dti-1336	255	65	risk	risk	NOUN
dti-1336	255	66	of	of	ADP
dti-1336	255	67	myocardial	myocardial	ADJ
dti-1336	255	68	infarction	infarction	NOUN
dti-1336	255	69	in	in	ADP
dti-1336	255	70	young	young	ADJ
dti-1336	255	71	women	woman	NOUN
dti-1336	255	72	.	.	PUNCT
dti-1336	256	1	blood	blood	NOUN
dti-1336	256	2	,	,	PUNCT
dti-1336	256	3	89(8):2817–21	89(8):2817–21	NUM
dti-1336	256	4	.	.	PUNCT
dti-1336	257	1	[	[	X
dti-1336	257	2	30	30	NUM
dti-1336	257	3	]	]	X
dti-1336	257	4	preston	preston	PROPN
dti-1336	257	5	,	,	PUNCT
dti-1336	257	6	f.e	f.e	PROPN
dti-1336	257	7	.	.	PROPN
dti-1336	257	8	,	,	PUNCT
dti-1336	257	9	rosendaal	rosendaal	PROPN
dti-1336	257	10	,	,	PUNCT
dti-1336	257	11	f.r	f.r	PROPN
dti-1336	257	12	.	.	PROPN
dti-1336	257	13	,	,	PUNCT
dti-1336	257	14	walker	walker	PROPN
dti-1336	257	15	,	,	PUNCT
dti-1336	257	16	i.d	i.d	PROPN
dti-1336	257	17	.	.	PROPN
dti-1336	257	18	,	,	PUNCT
dti-1336	257	19	briet	briet	PROPN
dti-1336	257	20	,	,	PUNCT
dti-1336	257	21	e.	e.	PROPN
dti-1336	257	22	,	,	PUNCT
dti-1336	257	23	berntorp	berntorp	PROPN
dti-1336	257	24	,	,	PUNCT
dti-1336	257	25	e.	e.	PROPN
dti-1336	257	26	,	,	PUNCT
dti-1336	257	27	conard	conard	PROPN
dti-1336	257	28	,	,	PUNCT
dti-1336	257	29	j.	j.	PROPN
dti-1336	257	30	,	,	PUNCT
dti-1336	257	31	fontcuberta	fontcuberta	PROPN
dti-1336	257	32	,	,	PUNCT
dti-1336	257	33	j.	j.	PROPN
dti-1336	257	34	,	,	PUNCT
dti-1336	257	35	makris	makris	PROPN
dti-1336	257	36	,	,	PUNCT
dti-1336	257	37	m.	m.	NOUN
dti-1336	257	38	,	,	PUNCT
dti-1336	257	39	mariani	mariani	PROPN
dti-1336	257	40	,	,	PUNCT
dti-1336	257	41	g.	g.	PROPN
dti-1336	257	42	,	,	PUNCT
dti-1336	257	43	noteboom	noteboom	PROPN
dti-1336	257	44	,	,	PUNCT
dti-1336	257	45	w.	w.	PROPN
dti-1336	257	46	,	,	PUNCT
dti-1336	257	47	pabinger	pabinger	PROPN
dti-1336	257	48	,	,	PUNCT
dti-1336	257	49	i.	i.	PROPN
dti-1336	257	50	,	,	PUNCT
dti-1336	257	51	legnani	legnani	PROPN
dti-1336	257	52	,	,	PUNCT
dti-1336	257	53	c.	c.	PROPN
dti-1336	257	54	,	,	PUNCT
dti-1336	257	55	scharrer	scharrer	NOUN
dti-1336	257	56	,	,	PUNCT
dti-1336	257	57	i.	i.	PROPN
dti-1336	257	58	,	,	PUNCT
dti-1336	257	59	schulman	schulman	PROPN
dti-1336	257	60	,	,	PUNCT
dti-1336	257	61	s.	s.	PROPN
dti-1336	257	62	and	and	CCONJ
dti-1336	257	63	van	van	PROPN
dti-1336	257	64	der	der	PROPN
dti-1336	257	65	meer	meer	PROPN
dti-1336	257	66	f.j	f.j	PROPN
dti-1336	257	67	.	.	PROPN
dti-1336	257	68	1996	1996	NUM
dti-1336	257	69	oct	oct	NOUN
dti-1336	257	70	5	5	NUM
dti-1336	257	71	.	.	NUM
dti-1336	257	72	increased	increase	VERB
dti-1336	257	73	fetal	fetal	ADJ
dti-1336	257	74	loss	loss	NOUN
dti-1336	257	75	in	in	ADP
dti-1336	257	76	women	woman	NOUN
dti-1336	257	77	with	with	ADP
dti-1336	257	78	heritable	heritable	ADJ
dti-1336	257	79	thrombophilia	thrombophilia	NOUN
dti-1336	257	80	.	.	PUNCT
dti-1336	258	1	lancet	lancet	PROPN
dti-1336	258	2	,	,	PUNCT
dti-1336	258	3	348(9032):913–6	348(9032):913–6	NUM
dti-1336	258	4	.	.	PUNCT
dti-1336	259	1	[	[	X
dti-1336	259	2	31	31	NUM
dti-1336	259	3	]	]	X
dti-1336	259	4	poort	poort	NOUN
dti-1336	259	5	,	,	PUNCT
dti-1336	259	6	s.r	s.r	PROPN
dti-1336	259	7	.	.	PROPN
dti-1336	259	8	,	,	PUNCT
dti-1336	259	9	rosendaal	rosendaal	PROPN
dti-1336	259	10	,	,	PUNCT
dti-1336	259	11	f.r	f.r	PROPN
dti-1336	259	12	.	.	PROPN
dti-1336	259	13	,	,	PUNCT
dti-1336	259	14	reitsma	reitsma	PROPN
dti-1336	259	15	,	,	PUNCT
dti-1336	259	16	p.h	p.h	PROPN
dti-1336	259	17	.	.	PROPN
dti-1336	259	18	and	and	CCONJ
dti-1336	259	19	bertina	bertina	PROPN
dti-1336	259	20	,	,	PUNCT
dti-1336	259	21	r.m	r.m	PROPN
dti-1336	259	22	.	.	PROPN
dti-1336	259	23	1996	1996	NUM
dti-1336	259	24	nov	nov	PROPN
dti-1336	259	25	15	15	NUM
dti-1336	259	26	.	.	PUNCT
dti-1336	260	1	a	a	DET
dti-1336	260	2	common	common	ADJ
dti-1336	260	3	genetic	genetic	ADJ
dti-1336	260	4	variation	variation	NOUN
dti-1336	260	5	in	in	ADP
dti-1336	260	6	the	the	DET
dti-1336	260	7	3’-untranslated	3’-untranslated	ADJ
dti-1336	260	8	region	region	NOUN
dti-1336	260	9	of	of	ADP
dti-1336	260	10	the	the	DET
dti-1336	260	11	prothrombin	prothrombin	NOUN
dti-1336	260	12	gene	gene	NOUN
dti-1336	260	13	is	be	AUX
dti-1336	260	14	associated	associate	VERB
dti-1336	260	15	with	with	ADP
dti-1336	260	16	elevated	elevated	ADJ
dti-1336	260	17	plasma	plasma	NOUN
dti-1336	260	18	prothrombin	prothrombin	NOUN
dti-1336	260	19	levels	level	NOUN
dti-1336	260	20	and	and	CCONJ
dti-1336	260	21	an	an	DET
dti-1336	260	22	increase	increase	NOUN
dti-1336	260	23	in	in	ADP
dti-1336	260	24	venous	venous	ADJ
dti-1336	260	25	thrombosis	thrombosis	NOUN
dti-1336	260	26	.	.	PUNCT
dti-1336	261	1	blood	blood	NOUN
dti-1336	261	2	,	,	PUNCT
dti-1336	261	3	88(10):3698–703	88(10):3698–703	NOUN
dti-1336	261	4	.	.	PUNCT
dti-1336	262	1	[	[	X
dti-1336	262	2	32	32	NUM
dti-1336	262	3	]	]	X
dti-1336	262	4	bank	bank	NOUN
dti-1336	262	5	,	,	PUNCT
dti-1336	262	6	i.	i.	PROPN
dti-1336	262	7	,	,	PUNCT
dti-1336	262	8	libourel	libourel	PROPN
dti-1336	262	9	,	,	PUNCT
dti-1336	262	10	e.j	e.j	PROPN
dti-1336	262	11	.	.	PROPN
dti-1336	262	12	,	,	PUNCT
dti-1336	262	13	middeldorp	middeldorp	PROPN
dti-1336	262	14	,	,	PUNCT
dti-1336	262	15	s.	s.	PROPN
dti-1336	262	16	et	et	PROPN
dti-1336	262	17	al	al	PROPN
dti-1336	262	18	.	.	PROPN
dti-1336	262	19	2004	2004	NUM
dti-1336	262	20	.	.	PUNCT
dti-1336	263	1	prothrombin	prothrombin	ADJ
dti-1336	263	2	20210a	20210a	PROPN
dti-1336	263	3	mutation	mutation	NOUN
dti-1336	263	4	:	:	PUNCT
dti-1336	263	5	a	a	DET
dti-1336	263	6	mild	mild	ADJ
dti-1336	263	7	risk	risk	NOUN
dti-1336	263	8	factor	factor	NOUN
dti-1336	263	9	for	for	ADP
dti-1336	263	10	venous	venous	ADJ
dti-1336	263	11	thromboembolism	thromboembolism	NOUN
dti-1336	263	12	but	but	CCONJ
dti-1336	263	13	not	not	PART
dti-1336	263	14	for	for	ADP
dti-1336	263	15	arterial	arterial	ADJ
dti-1336	263	16	thrombotic	thrombotic	ADJ
dti-1336	263	17	disease	disease	NOUN
dti-1336	263	18	and	and	CCONJ
dti-1336	263	19	pregnancy	pregnancy	NOUN
dti-1336	263	20	-	-	PUNCT
dti-1336	263	21	related	relate	VERB
dti-1336	263	22	complications	complication	NOUN
dti-1336	263	23	in	in	ADP
dti-1336	263	24	a	a	DET
dti-1336	263	25	family	family	NOUN
dti-1336	263	26	study	study	NOUN
dti-1336	263	27	.	.	PUNCT
dti-1336	264	1	arch	arch	NOUN
dti-1336	264	2	.	.	PUNCT
dti-1336	265	1	intern	intern	NOUN
dti-1336	265	2	.	.	PUNCT
dti-1336	266	1	med	med	PROPN
dti-1336	266	2	.	.	PROPN
dti-1336	266	3	,	,	PUNCT
dti-1336	266	4	164:1932–7	164:1932–7	X
dti-1336	266	5	.	.	PUNCT
dti-1336	267	1	[	[	X
dti-1336	267	2	33	33	NUM
dti-1336	267	3	]	]	X
dti-1336	267	4	frosst	frosst	ADJ
dti-1336	267	5	,	,	PUNCT
dti-1336	267	6	p.	p.	NOUN
dti-1336	267	7	,	,	PUNCT
dti-1336	267	8	blom	blom	PROPN
dti-1336	267	9	,	,	PUNCT
dti-1336	267	10	h.j	h.j	PROPN
dti-1336	267	11	.	.	PROPN
dti-1336	267	12	,	,	PUNCT
dti-1336	267	13	milos	milos	PROPN
dti-1336	267	14	,	,	PUNCT
dti-1336	267	15	r.	r.	PROPN
dti-1336	267	16	,	,	PUNCT
dti-1336	267	17	goyette	goyette	NOUN
dti-1336	267	18	,	,	PUNCT
dti-1336	267	19	p.	p.	NOUN
dti-1336	267	20	,	,	PUNCT
dti-1336	267	21	sheppard	sheppard	PROPN
dti-1336	267	22	,	,	PUNCT
dti-1336	267	23	c.a	c.a	PROPN
dti-1336	267	24	.	.	PROPN
dti-1336	267	25	,	,	PUNCT
dti-1336	267	26	matthews	matthews	PROPN
dti-1336	267	27	,	,	PUNCT
dti-1336	267	28	r.g	r.g	PROPN
dti-1336	267	29	.	.	PROPN
dti-1336	267	30	,	,	PUNCT
dti-1336	267	31	boers	boer	NOUN
dti-1336	267	32	,	,	PUNCT
dti-1336	267	33	g.j	g.j	PROPN
dti-1336	267	34	.	.	PROPN
dti-1336	267	35	,	,	PUNCT
dti-1336	267	36	den	den	PROPN
dti-1336	267	37	heijer	heijer	PROPN
dti-1336	267	38	,	,	PUNCT
dti-1336	267	39	m.	m.	NOUN
dti-1336	267	40	,	,	PUNCT
dti-1336	267	41	kluijtmans	kluijtmans	PROPN
dti-1336	267	42	,	,	PUNCT
dti-1336	267	43	l.a	l.a	PROPN
dti-1336	267	44	.	.	PROPN
dti-1336	267	45	,	,	PUNCT
dti-1336	267	46	van	van	PROPN
dti-1336	267	47	den	den	PROPN
dti-1336	267	48	heuvel	heuvel	PROPN
dti-1336	267	49	,	,	PUNCT
dti-1336	267	50	l.p	l.p	PROPN
dti-1336	267	51	.	.	PROPN
dti-1336	267	52	et	et	PROPN
dti-1336	267	53	al	al	PROPN
dti-1336	267	54	.	.	PROPN
dti-1336	267	55	1995	1995	NUM
dti-1336	267	56	may	may	AUX
dti-1336	267	57	.	.	PUNCT
dti-1336	268	1	a	a	DET
dti-1336	268	2	candidate	candidate	NOUN
dti-1336	268	3	genetic	genetic	ADJ
dti-1336	268	4	risk	risk	NOUN
dti-1336	268	5	factor	factor	NOUN
dti-1336	268	6	for	for	ADP
dti-1336	268	7	vascular	vascular	ADJ
dti-1336	268	8	disease	disease	NOUN
dti-1336	268	9	:	:	PUNCT
dti-1336	268	10	a	a	DET
dti-1336	268	11	common	common	ADJ
dti-1336	268	12	mutation	mutation	NOUN
dti-1336	268	13	in	in	ADP
dti-1336	268	14	methylenetetrahydrofolate	methylenetetrahydrofolate	ADJ
dti-1336	268	15	reductase	reductase	NOUN
dti-1336	268	16	.	.	PUNCT
dti-1336	269	1	nat	nat	PROPN
dti-1336	269	2	.	.	PUNCT
dti-1336	270	1	genet	genet	PROPN
dti-1336	270	2	.	.	PUNCT
dti-1336	270	3	,	,	PUNCT
dti-1336	271	1	10(1):111–3	10(1):111–3	NUM
dti-1336	271	2	.	.	PUNCT
dti-1336	272	1	[	[	X
dti-1336	272	2	34	34	NUM
dti-1336	272	3	]	]	X
dti-1336	272	4	den	den	PROPN
dti-1336	272	5	heijer	heijer	PROPN
dti-1336	272	6	,	,	PUNCT
dti-1336	272	7	m.	m.	NOUN
dti-1336	272	8	,	,	PUNCT
dti-1336	272	9	lewington	lewington	PROPN
dti-1336	272	10	,	,	PUNCT
dti-1336	272	11	s.	s.	PROPN
dti-1336	272	12	and	and	CCONJ
dti-1336	272	13	clarke	clarke	PROPN
dti-1336	272	14	,	,	PUNCT
dti-1336	272	15	r.	r.	PROPN
dti-1336	272	16	2005	2005	NUM
dti-1336	272	17	.	.	PUNCT
dti-1336	273	1	homocysteine	homocysteine	NOUN
dti-1336	273	2	,	,	PUNCT
dti-1336	273	3	mthfr	mthfr	PROPN
dti-1336	273	4	.	.	PUNCT
dti-1336	274	1	and	and	CCONJ
dti-1336	274	2	risk	risk	NOUN
dti-1336	274	3	of	of	ADP
dti-1336	274	4	venous	venous	ADJ
dti-1336	274	5	thrombosis	thrombosis	NOUN
dti-1336	274	6	:	:	PUNCT
dti-1336	274	7	a	a	DET
dti-1336	274	8	meta	meta	ADJ
dti-1336	274	9	-	-	PUNCT
dti-1336	274	10	analysis	analysis	NOUN
dti-1336	274	11	of	of	ADP
dti-1336	274	12	published	publish	VERB
dti-1336	274	13	epidemiological	epidemiological	ADJ
dti-1336	274	14	studies	study	NOUN
dti-1336	274	15	.	.	PUNCT
dti-1336	275	1	j.	j.	PROPN
dti-1336	275	2	thromb	thromb	PROPN
dti-1336	275	3	.	.	PUNCT
dti-1336	276	1	haemost	haemost	PROPN
dti-1336	276	2	,	,	PUNCT
dti-1336	276	3	3:292–9	3:292–9	NUM
dti-1336	276	4	.	.	PUNCT
dti-1336	277	1	[	[	X
dti-1336	277	2	35	35	NUM
dti-1336	277	3	]	]	PUNCT
dti-1336	277	4	lodi	lodi	NOUN
dti-1336	277	5	,	,	PUNCT
dti-1336	277	6	s.	s.	PROPN
dti-1336	277	7	,	,	PUNCT
dti-1336	277	8	isa	isa	PROPN
dti-1336	277	9	,	,	PUNCT
dti-1336	277	10	l.	l.	PROPN
dti-1336	277	11	,	,	PUNCT
dti-1336	277	12	pollini	pollini	PROPN
dti-1336	277	13	,	,	PUNCT
dti-1336	277	14	e.	e.	PROPN
dti-1336	277	15	,	,	PUNCT
dti-1336	277	16	bravo	bravo	PROPN
dti-1336	277	17	,	,	PUNCT
dti-1336	277	18	a.f	a.f	PROPN
dti-1336	277	19	.	.	PROPN
dti-1336	277	20	and	and	CCONJ
dti-1336	277	21	scalvini	scalvini	PROPN
dti-1336	277	22	,	,	PUNCT
dti-1336	277	23	a.	a.	NOUN
dti-1336	277	24	1984	1984	NUM
dti-1336	277	25	jul	jul	PROPN
dti-1336	277	26	.	.	PROPN
dti-1336	277	27	defective	defective	ADJ
dti-1336	277	28	intrinsic	intrinsic	ADJ
dti-1336	277	29	fi	fi	NOUN
dti-1336	277	30	brinolytic	brinolytic	ADJ
dti-1336	277	31	activity	activity	NOUN
dti-1336	277	32	in	in	ADP
dti-1336	277	33	a	a	DET
dti-1336	277	34	patient	patient	NOUN
dti-1336	277	35	with	with	ADP
dti-1336	277	36	severe	severe	ADJ
dti-1336	277	37	factor	factor	NOUN
dti-1336	277	38	xii	xii	NOUN
dti-1336	277	39	-	-	PUNCT
dti-1336	277	40	defi	defi	NOUN
dti-1336	277	41	ciency	ciency	NOUN
dti-1336	277	42	and	and	CCONJ
dti-1336	277	43	myocardial	myocardial	ADJ
dti-1336	277	44	infarction	infarction	NOUN
dti-1336	277	45	.	.	PUNCT
dti-1336	278	1	scand	scand	PROPN
dti-1336	278	2	j.	j.	PROPN
dti-1336	278	3	haematol	haematol	PROPN
dti-1336	278	4	,	,	PUNCT
dti-1336	278	5	33(1):80–2	33(1):80–2	NUM
dti-1336	278	6	.	.	PUNCT
dti-1336	279	1	lammle	lammle	NOUN
dti-1336	279	2	et	et	PROPN
dti-1336	279	3	al	al	PROPN
dti-1336	279	4	.	.	PROPN
dti-1336	279	5	,1991	,1991	PROPN
dti-1336	279	6	;	;	PUNCT
dti-1336	279	7	factorxiirodeghiero	factorxiirodeghiero	X
dti-1336	279	8	et	et	PROPN
dti-1336	279	9	al	al	PROPN
dti-1336	279	10	.	.	PROPN
dti-1336	279	11	,	,	PUNCT
dti-1336	279	12	1992	1992	NUM
dti-1336	279	13	)	)	PUNCT
dti-1336	279	14	factorxii	factorxii	NOUN
dti-1336	279	15	.	.	PUNCT
dti-1336	280	1	[	[	X
dti-1336	280	2	36	36	NUM
dti-1336	280	3	]	]	PUNCT
dti-1336	280	4	lammle	lammle	NOUN
dti-1336	280	5	,	,	PUNCT
dti-1336	280	6	b.	b.	PROPN
dti-1336	280	7	,	,	PUNCT
dti-1336	280	8	wuillemin	wuillemin	NOUN
dti-1336	280	9	,	,	PUNCT
dti-1336	280	10	w.a	w.a	PROPN
dti-1336	280	11	.	.	PROPN
dti-1336	280	12	,	,	PUNCT
dti-1336	280	13	huer	huer	PROPN
dti-1336	280	14	,	,	PUNCT
dti-1336	280	15	i.	i.	PROPN
dti-1336	280	16	,	,	PUNCT
dti-1336	280	17	krauskopf	krauskopf	PROPN
dti-1336	280	18	,	,	PUNCT
dti-1336	280	19	m.	m.	NOUN
dti-1336	280	20	,	,	PUNCT
dti-1336	280	21	zurcher	zurcher	PROPN
dti-1336	280	22	,	,	PUNCT
dti-1336	280	23	c.	c.	PROPN
dti-1336	280	24	,	,	PUNCT
dti-1336	280	25	pfl	pfl	NOUN
dti-1336	280	26	ugshaupt	ugshaupt	ADJ
dti-1336	280	27	,	,	PUNCT
dti-1336	280	28	r.	r.	PROPN
dti-1336	280	29	and	and	CCONJ
dti-1336	280	30	furlan	furlan	NOUN
dti-1336	280	31	,	,	PUNCT
dti-1336	280	32	m.	m.	NOUN
dti-1336	280	33	1991	1991	NUM
dti-1336	280	34	.	.	PUNCT
dti-1336	281	1	thromboembolism	thromboembolism	NOUN
dti-1336	281	2	and	and	CCONJ
dti-1336	281	3	bleeding	bleed	VERB
dti-1336	281	4	tendency	tendency	NOUN
dti-1336	281	5	in	in	ADP
dti-1336	281	6	congenital	congenital	ADJ
dti-1336	281	7	factor	factor	NOUN
dti-1336	281	8	xii	xii	NOUN
dti-1336	281	9	defi	defi	NOUN
dti-1336	281	10	ciency	ciency	NOUN
dti-1336	281	11	—	—	PUNCT
dti-1336	281	12	a	a	DET
dti-1336	281	13	study	study	NOUN
dti-1336	281	14	on	on	ADP
dti-1336	281	15	74	74	NUM
dti-1336	281	16	subjects	subject	NOUN
dti-1336	281	17	from	from	ADP
dti-1336	281	18	14	14	NUM
dti-1336	281	19	swiss	swiss	ADJ
dti-1336	281	20	families	family	NOUN
dti-1336	281	21	.	.	PUNCT
dti-1336	282	1	thromb	thromb	NOUN
dti-1336	282	2	.	.	PUNCT
dti-1336	283	1	haemost	haemost	PROPN
dti-1336	283	2	,	,	PUNCT
dti-1336	283	3	65:117–21	65:117–21	NOUN
dti-1336	283	4	.	.	PUNCT
dti-1336	284	1	[	[	X
dti-1336	284	2	37	37	NUM
dti-1336	284	3	]	]	X
dti-1336	284	4	rodeghiero	rodeghiero	NOUN
dti-1336	284	5	,	,	PUNCT
dti-1336	284	6	f.	f.	PROPN
dti-1336	284	7	,	,	PUNCT
dti-1336	284	8	castaman	castaman	PROPN
dti-1336	284	9	,	,	PUNCT
dti-1336	284	10	g.	g.	PROPN
dti-1336	284	11	,	,	PUNCT
dti-1336	284	12	ruggeri	ruggeri	PROPN
dti-1336	284	13	,	,	PUNCT
dti-1336	284	14	m.	m.	NOUN
dti-1336	284	15	and	and	CCONJ
dti-1336	284	16	tosetto	tosetto	NOUN
dti-1336	284	17	,	,	PUNCT
dti-1336	284	18	a.	a.	NOUN
dti-1336	284	19	1992	1992	NUM
dti-1336	284	20	.	.	PUNCT
dti-1336	285	1	thrombosis	thrombosis	NOUN
dti-1336	285	2	in	in	ADP
dti-1336	285	3	subjects	subject	NOUN
dti-1336	285	4	with	with	ADP
dti-1336	285	5	homozygous	homozygous	ADJ
dti-1336	285	6	and	and	CCONJ
dti-1336	285	7	heterozygous	heterozygous	ADJ
dti-1336	285	8	factor	factor	NOUN
dti-1336	285	9	xii	xii	NOUN
dti-1336	285	10	defi	defi	NOUN
dti-1336	285	11	ciency	ciency	NOUN
dti-1336	285	12	.	.	PUNCT
dti-1336	286	1	thromb	thromb	NOUN
dti-1336	286	2	.	.	PUNCT
dti-1336	287	1	haemost	haemost	PROPN
dti-1336	287	2	,	,	PUNCT
dti-1336	287	3	67:590–1	67:590–1	NUM
dti-1336	287	4	.	.	PUNCT
dti-1336	288	1	[	[	X
dti-1336	288	2	38	38	NUM
dti-1336	288	3	]	]	X
dti-1336	288	4	kierkegaard	kierkegaard	PROPN
dti-1336	288	5	,	,	PUNCT
dti-1336	288	6	a.	a.	NOUN
dti-1336	288	7	1983	1983	NUM
dti-1336	288	8	.	.	PUNCT
dti-1336	289	1	incidence	incidence	NOUN
dti-1336	289	2	and	and	CCONJ
dti-1336	289	3	diagnosis	diagnosis	NOUN
dti-1336	289	4	of	of	ADP
dti-1336	289	5	deep	deep	ADJ
dti-1336	289	6	vein	vein	ADJ
dti-1336	289	7	thrombosis	thrombosis	NOUN
dti-1336	289	8	associated	associate	VERB
dti-1336	289	9	with	with	ADP
dti-1336	289	10	pregnancy	pregnancy	NOUN
dti-1336	289	11	.	.	PUNCT
dti-1336	290	1	acta	acta	PROPN
dti-1336	290	2	.	.	PUNCT
dti-1336	291	1	obstet	obstet	PROPN
dti-1336	291	2	.	.	PUNCT
dti-1336	292	1	gynecol	gynecol	PROPN
dti-1336	292	2	.	.	PUNCT
dti-1336	293	1	scand	scand	PROPN
dti-1336	293	2	,	,	PUNCT
dti-1336	293	3	62:239–43	62:239–43	PROPN
dti-1336	293	4	.	.	PUNCT
dti-1336	294	1	[	[	X
dti-1336	294	2	39	39	NUM
dti-1336	294	3	]	]	X
dti-1336	294	4	mccoll	mccoll	PROPN
dti-1336	294	5	,	,	PUNCT
dti-1336	294	6	m.d	m.d	PROPN
dti-1336	294	7	.	.	PROPN
dti-1336	294	8	,	,	PUNCT
dti-1336	294	9	ramsay	ramsay	PROPN
dti-1336	294	10	,	,	PUNCT
dti-1336	294	11	j.e	j.e	PROPN
dti-1336	294	12	.	.	PROPN
dti-1336	294	13	,	,	PUNCT
dti-1336	294	14	tait	tait	PROPN
dti-1336	294	15	,	,	PUNCT
dti-1336	294	16	r.c	r.c	PROPN
dti-1336	294	17	.	.	PROPN
dti-1336	294	18	et	et	PROPN
dti-1336	294	19	al	al	PROPN
dti-1336	294	20	.	.	PROPN
dti-1336	294	21	1997	1997	NUM
dti-1336	294	22	.	.	PUNCT
dti-1336	295	1	risk	risk	NOUN
dti-1336	295	2	factors	factor	NOUN
dti-1336	295	3	for	for	ADP
dti-1336	295	4	pregnancy	pregnancy	NOUN
dti-1336	295	5	associated	associate	VERB
dti-1336	295	6	venous	venous	ADJ
dti-1336	295	7	thromboembolism	thromboembolism	NOUN
dti-1336	295	8	.	.	PUNCT
dti-1336	296	1	thromb	thromb	NOUN
dti-1336	296	2	.	.	PUNCT
dti-1336	297	1	haemost	haemost	VERB
dti-1336	297	2	,	,	PUNCT
dti-1336	297	3	78:1183–8	78:1183–8	NUM
dti-1336	297	4	.	.	PUNCT
dti-1336	298	1	[	[	X
dti-1336	298	2	40	40	NUM
dti-1336	298	3	]	]	PUNCT
dti-1336	298	4	sachs	sachs	PROPN
dti-1336	298	5	,	,	PUNCT
dti-1336	298	6	b.p	b.p	PROPN
dti-1336	298	7	.	.	PROPN
dti-1336	298	8	,	,	PUNCT
dti-1336	298	9	brown	brown	PROPN
dti-1336	298	10	,	,	PUNCT
dti-1336	298	11	d.a	d.a	PROPN
dti-1336	298	12	.	.	PROPN
dti-1336	298	13	,	,	PUNCT
dti-1336	298	14	driscoll	driscoll	PROPN
dti-1336	298	15	,	,	PUNCT
dti-1336	298	16	s.g	s.g	PROPN
dti-1336	298	17	.	.	PROPN
dti-1336	298	18	,	,	PUNCT
dti-1336	298	19	schulman	schulman	PROPN
dti-1336	298	20	,	,	PUNCT
dti-1336	298	21	e.	e.	PROPN
dti-1336	298	22	,	,	PUNCT
dti-1336	298	23	acker	acker	PROPN
dti-1336	298	24	,	,	PUNCT
dti-1336	298	25	d.	d.	PROPN
dti-1336	298	26	,	,	PUNCT
dti-1336	298	27	ransil	ransil	PROPN
dti-1336	298	28	,	,	PUNCT
dti-1336	298	29	b.j	b.j	PROPN
dti-1336	298	30	.	.	PROPN
dti-1336	298	31	and	and	CCONJ
dti-1336	298	32	jewett	jewett	PROPN
dti-1336	298	33	,	,	PUNCT
dti-1336	298	34	j.f	j.f	PROPN
dti-1336	298	35	.	.	PROPN
dti-1336	298	36	1987	1987	NUM
dti-1336	298	37	mar	mar	PROPN
dti-1336	298	38	12	12	NUM
dti-1336	298	39	.	.	PUNCT
dti-1336	299	1	maternal	maternal	ADJ
dti-1336	299	2	mortality	mortality	NOUN
dti-1336	299	3	in	in	ADP
dti-1336	299	4	massachusetts	massachusetts	PROPN
dti-1336	299	5	.	.	PUNCT
dti-1336	300	1	trends	trend	NOUN
dti-1336	300	2	and	and	CCONJ
dti-1336	300	3	prevention	prevention	NOUN
dti-1336	300	4	.	.	PUNCT
dti-1336	301	1	n.	n.	PROPN
dti-1336	301	2	engl	engl	PROPN
dti-1336	301	3	.	.	PUNCT
dti-1336	302	1	j.	j.	PROPN
dti-1336	302	2	med	med	PROPN
dti-1336	302	3	.	.	PROPN
dti-1336	302	4	,	,	PUNCT
dti-1336	302	5	316(11):667–72	316(11):667–72	NUM
dti-1336	302	6	.	.	PUNCT
dti-1336	303	1	[	[	X
dti-1336	303	2	41	41	NUM
dti-1336	303	3	]	]	X
dti-1336	303	4	comp	comp	X
dti-1336	303	5	,	,	PUNCT
dti-1336	303	6	p.c	p.c	PROPN
dti-1336	303	7	.	.	PROPN
dti-1336	303	8	,	,	PUNCT
dti-1336	303	9	thurnau	thurnau	PROPN
dti-1336	303	10	,	,	PUNCT
dti-1336	303	11	g.r	g.r	PROPN
dti-1336	303	12	.	.	PROPN
dti-1336	303	13	,	,	PUNCT
dti-1336	303	14	welsh	welsh	PROPN
dti-1336	303	15	,	,	PUNCT
dti-1336	303	16	j.	j.	PROPN
dti-1336	303	17	and	and	CCONJ
dti-1336	303	18	esmon	esmon	PROPN
dti-1336	303	19	,	,	PUNCT
dti-1336	303	20	c.t	c.t	PROPN
dti-1336	303	21	.	.	PROPN
dti-1336	303	22	oct	oct	PROPN
dti-1336	303	23	1986	1986	NUM
dti-1336	303	24	.	.	PUNCT
dti-1336	304	1	functional	functional	ADJ
dti-1336	304	2	and	and	CCONJ
dti-1336	304	3	immunologic	immunologic	ADJ
dti-1336	304	4	protein	protein	NOUN
dti-1336	304	5	s	s	PART
dti-1336	304	6	levels	level	NOUN
dti-1336	304	7	are	be	AUX
dti-1336	304	8	decreased	decrease	VERB
dti-1336	304	9	during	during	ADP
dti-1336	304	10	pregnancy	pregnancy	NOUN
dti-1336	304	11	.	.	PUNCT
dti-1336	305	1	blood	blood	NOUN
dti-1336	305	2	,	,	PUNCT
dti-1336	305	3	68:881–5	68:881–5	NUM
dti-1336	305	4	.	.	PUNCT
dti-1336	306	1	[	[	X
dti-1336	306	2	42	42	NUM
dti-1336	306	3	]	]	PUNCT
dti-1336	306	4	rosing	rosing	PROPN
dti-1336	306	5	,	,	PUNCT
dti-1336	306	6	j.	j.	PROPN
dti-1336	306	7	,	,	PUNCT
dti-1336	306	8	middeldorp	middeldorp	PROPN
dti-1336	306	9	,	,	PUNCT
dti-1336	306	10	s.	s.	PROPN
dti-1336	306	11	,	,	PUNCT
dti-1336	306	12	curvers	curver	NOUN
dti-1336	306	13	,	,	PUNCT
dti-1336	306	14	j.	j.	PROPN
dti-1336	306	15	et	et	PROPN
dti-1336	306	16	al	al	PROPN
dti-1336	306	17	.	.	PROPN
dti-1336	306	18	1999	1999	NUM
dti-1336	306	19	.	.	PUNCT
dti-1336	307	1	low	low	ADJ
dti-1336	307	2	-	-	PUNCT
dti-1336	307	3	dose	dose	NOUN
dti-1336	307	4	oral	oral	ADJ
dti-1336	307	5	contraceptives	contraceptive	NOUN
dti-1336	307	6	and	and	CCONJ
dti-1336	307	7	acquired	acquire	VERB
dti-1336	307	8	resistance	resistance	NOUN
dti-1336	307	9	to	to	ADP
dti-1336	307	10	activated	activate	VERB
dti-1336	307	11	protein	protein	NOUN
dti-1336	307	12	c	c	NOUN
dti-1336	307	13	:	:	PUNCT
dti-1336	307	14	a	a	DET
dti-1336	307	15	randomised	randomised	ADJ
dti-1336	307	16	cross	cross	NOUN
dti-1336	307	17	-	-	ADJ
dti-1336	307	18	over	over	ADP
dti-1336	307	19	study	study	NOUN
dti-1336	307	20	.	.	PUNCT
dti-1336	308	1	lancet	lancet	PROPN
dti-1336	308	2	,	,	PUNCT
dti-1336	308	3	354:2036–40	354:2036–40	NUM
dti-1336	308	4	.	.	PUNCT
dti-1336	309	1	[	[	X
dti-1336	309	2	43	43	NUM
dti-1336	309	3	]	]	X
dti-1336	309	4	middeldorp	middeldorp	PROPN
dti-1336	309	5	,	,	PUNCT
dti-1336	309	6	s.	s.	PROPN
dti-1336	309	7	,	,	PUNCT
dti-1336	309	8	meijers	meijers	PROPN
dti-1336	309	9	,	,	PUNCT
dti-1336	309	10	j.c.m	j.c.m	PROPN
dti-1336	309	11	.	.	PROPN
dti-1336	309	12	,	,	PUNCT
dti-1336	309	13	van	van	PROPN
dti-1336	309	14	den	den	PROPN
dti-1336	309	15	ende	ende	PROPN
dti-1336	309	16	,	,	PUNCT
dti-1336	309	17	a.e	a.e	PROPN
dti-1336	309	18	.	.	PROPN
dti-1336	309	19	et	et	PROPN
dti-1336	309	20	al	al	PROPN
dti-1336	309	21	.	.	PROPN
dti-1336	309	22	2000	2000	NUM
dti-1336	309	23	.	.	PUNCT
dti-1336	310	1	effects	effect	NOUN
dti-1336	310	2	on	on	ADP
dti-1336	310	3	coagulation	coagulation	NOUN
dti-1336	310	4	of	of	ADP
dti-1336	310	5	levonorgestreland	levonorgestreland	NOUN
dti-1336	310	6	desogestrelcontaining	desogestrelcontaine	VERB
dti-1336	310	7	low	low	ADJ
dti-1336	310	8	dose	dose	NOUN
dti-1336	310	9	oral	oral	ADJ
dti-1336	310	10	contraceptives	contraceptive	NOUN
dti-1336	310	11	:	:	PUNCT
dti-1336	310	12	a	a	DET
dti-1336	310	13	cross	cross	ADJ
dti-1336	310	14	-	-	ADJ
dti-1336	310	15	over	over	ADP
dti-1336	310	16	study	study	NOUN
dti-1336	310	17	.	.	PUNCT
dti-1336	311	1	thromb	thromb	PROPN
dti-1336	311	2	.	.	PUNCT
dti-1336	312	1	haemost	haemost	PROPN
dti-1336	312	2	,	,	PUNCT
dti-1336	312	3	84:4–8	84:4–8	NUM
dti-1336	312	4	.	.	PUNCT
dti-1336	313	1	[	[	X
dti-1336	313	2	44	44	NUM
dti-1336	313	3	]	]	PUNCT
dti-1336	313	4	booth	booth	NOUN
dti-1336	313	5	,	,	PUNCT
dti-1336	313	6	n.a	n.a	PROPN
dti-1336	313	7	.	.	PROPN
dti-1336	313	8	,	,	PUNCT
dti-1336	313	9	reith	reith	PROPN
dti-1336	313	10	,	,	PUNCT
dti-1336	313	11	a.	a.	NOUN
dti-1336	313	12	and	and	CCONJ
dti-1336	313	13	bennett	bennett	PROPN
dti-1336	313	14	,	,	PUNCT
dti-1336	313	15	b.	b.	PROPN
dti-1336	313	16	1988	1988	NUM
dti-1336	313	17	feb	feb	PROPN
dti-1336	313	18	25	25	NUM
dti-1336	313	19	.	.	PUNCT
dti-1336	313	20	a	a	DET
dti-1336	313	21	plasminogen	plasminogen	NOUN
dti-1336	313	22	activator	activator	NOUN
dti-1336	313	23	inhibitor	inhibitor	NOUN
dti-1336	313	24	(	(	PUNCT
dti-1336	313	25	pai-2	pai-2	NOUN
dti-1336	313	26	)	)	PUNCT
dti-1336	313	27	circulates	circulate	NOUN
dti-1336	313	28	in	in	ADP
dti-1336	313	29	two	two	NUM
dti-1336	313	30	molecular	molecular	ADJ
dti-1336	313	31	forms	form	NOUN
dti-1336	313	32	during	during	ADP
dti-1336	313	33	pregnancy	pregnancy	NOUN
dti-1336	313	34	.	.	PUNCT
dti-1336	314	1	thromb	thromb	NOUN
dti-1336	314	2	.	.	PUNCT
dti-1336	315	1	haemost	haemost	PROPN
dti-1336	315	2	,	,	PUNCT
dti-1336	315	3	59(1):77–9	59(1):77–9	X
dti-1336	315	4	.	.	PUNCT
dti-1336	316	1	[	[	X
dti-1336	316	2	45	45	NUM
dti-1336	316	3	]	]	PUNCT
dti-1336	316	4	meijers	meijer	NOUN
dti-1336	316	5	,	,	PUNCT
dti-1336	316	6	j.c.m	j.c.m	PROPN
dti-1336	316	7	.	.	PROPN
dti-1336	316	8	,	,	PUNCT
dti-1336	316	9	middeldorp	middeldorp	PROPN
dti-1336	316	10	,	,	PUNCT
dti-1336	316	11	s.	s.	PROPN
dti-1336	316	12	,	,	PUNCT
dti-1336	316	13	tekelenburg	tekelenburg	PROPN
dti-1336	316	14	,	,	PUNCT
dti-1336	316	15	w.	w.	PROPN
dti-1336	316	16	et	et	PROPN
dti-1336	316	17	al	al	PROPN
dti-1336	316	18	.	.	PROPN
dti-1336	316	19	2000	2000	NUM
dti-1336	316	20	.	.	PUNCT
dti-1336	316	21	increased	increase	VERB
dti-1336	316	22	fi	fi	NOUN
dti-1336	316	23	brinolytic	brinolytic	ADJ
dti-1336	316	24	activity	activity	NOUN
dti-1336	316	25	during	during	ADP
dti-1336	316	26	use	use	NOUN
dti-1336	316	27	of	of	ADP
dti-1336	316	28	oral	oral	ADJ
dti-1336	316	29	contraceptives	contraceptive	NOUN
dti-1336	316	30	is	be	AUX
dti-1336	316	31	counteracted	counteract	VERB
dti-1336	316	32	by	by	ADP
dti-1336	316	33	an	an	DET
dti-1336	316	34	enhanced	enhanced	ADJ
dti-1336	316	35	factor	factor	NOUN
dti-1336	316	36	xi	xi	NOUN
dti-1336	316	37	-	-	PUNCT
dti-1336	316	38	independent	independent	NOUN
dti-1336	316	39	down	down	ADP
dti-1336	316	40	regulation	regulation	NOUN
dti-1336	316	41	of	of	ADP
dti-1336	316	42	fi	fi	NOUN
dti-1336	316	43	brinolysis	brinolysis	NOUN
dti-1336	316	44	:	:	PUNCT
dti-1336	316	45	a	a	DET
dti-1336	316	46	randomized	randomize	VERB
dti-1336	316	47	crossover	crossover	NOUN
dti-1336	316	48	study	study	NOUN
dti-1336	316	49	of	of	ADP
dti-1336	316	50	two	two	NUM
dti-1336	316	51	low	low	ADJ
dti-1336	316	52	-	-	PUNCT
dti-1336	316	53	dose	dose	NOUN
dti-1336	316	54	oral	oral	ADJ
dti-1336	316	55	contraceptives	contraceptive	NOUN
dti-1336	316	56	.	.	PUNCT
dti-1336	317	1	thromb	thromb	NOUN
dti-1336	317	2	.	.	PUNCT
dti-1336	318	1	haemost	haemost	PROPN
dti-1336	318	2	,	,	PUNCT
dti-1336	318	3	84:9–14	84:9–14	NUM
dti-1336	318	4	.	.	PUNCT
dti-1336	319	1	[	[	X
dti-1336	319	2	46	46	NUM
dti-1336	319	3	]	]	PUNCT
dti-1336	319	4	world	world	PROPN
dti-1336	319	5	health	health	NOUN
dti-1336	319	6	organization	organization	NOUN
dti-1336	319	7	,	,	PUNCT
dti-1336	319	8	1996	1996	NUM
dti-1336	319	9	.	.	PUNCT
dti-1336	320	1	ischaemic	ischaemic	ADJ
dti-1336	320	2	stroke	stroke	NOUN
dti-1336	320	3	and	and	CCONJ
dti-1336	320	4	combined	combine	VERB
dti-1336	320	5	oral	oral	ADJ
dti-1336	320	6	contraceptives	contraceptive	NOUN
dti-1336	320	7	:	:	PUNCT
dti-1336	320	8	results	result	NOUN
dti-1336	320	9	of	of	ADP
dti-1336	320	10	an	an	DET
dti-1336	320	11	international	international	ADJ
dti-1336	320	12	,	,	PUNCT
dti-1336	320	13	multicentre	multicentre	NOUN
dti-1336	320	14	,	,	PUNCT
dti-1336	320	15	casecontrol	casecontrol	NOUN
dti-1336	320	16	study	study	NOUN
dti-1336	320	17	.	.	PUNCT
dti-1336	321	1	who	who	PRON
dti-1336	321	2	collaborative	collaborative	ADJ
dti-1336	321	3	study	study	NOUN
dti-1336	321	4	of	of	ADP
dti-1336	321	5	cardiovascular	cardiovascular	ADJ
dti-1336	321	6	disease	disease	NOUN
dti-1336	321	7	and	and	CCONJ
dti-1336	321	8	steroid	steroid	NOUN
dti-1336	321	9	hormone	hormone	NOUN
dti-1336	321	10	contraception	contraception	NOUN
dti-1336	321	11	.	.	PUNCT
dti-1336	322	1	lancet	lancet	PROPN
dti-1336	322	2	,	,	PUNCT
dti-1336	322	3	348:498–505	348:498–505	NUM
dti-1336	322	4	.	.	PUNCT
dti-1336	323	1	[	[	X
dti-1336	323	2	47	47	NUM
dti-1336	323	3	]	]	X
dti-1336	323	4	daly	daly	PROPN
dti-1336	323	5	,	,	PUNCT
dti-1336	323	6	e.	e.	PROPN
dti-1336	323	7	,	,	PUNCT
dti-1336	323	8	vessey	vessey	NOUN
dti-1336	323	9	,	,	PUNCT
dti-1336	323	10	m.p	m.p	PROPN
dti-1336	323	11	.	.	PROPN
dti-1336	323	12	,	,	PUNCT
dti-1336	323	13	hawkins	hawkins	PROPN
dti-1336	323	14	,	,	PUNCT
dti-1336	323	15	m.m	m.m	PROPN
dti-1336	323	16	.	.	PROPN
dti-1336	323	17	,	,	PUNCT
dti-1336	323	18	carson	carson	PROPN
dti-1336	323	19	,	,	PUNCT
dti-1336	323	20	j.l	j.l	PROPN
dti-1336	323	21	.	.	PROPN
dti-1336	323	22	,	,	PUNCT
dti-1336	323	23	gough	gough	PROPN
dti-1336	323	24	,	,	PUNCT
dti-1336	323	25	p.	p.	NOUN
dti-1336	323	26	and	and	CCONJ
dti-1336	323	27	marsh	marsh	PROPN
dti-1336	323	28	,	,	PUNCT
dti-1336	323	29	s.	s.	PROPN
dti-1336	323	30	1996	1996	NUM
dti-1336	323	31	.	.	PUNCT
dti-1336	324	1	risk	risk	NOUN
dti-1336	324	2	of	of	ADP
dti-1336	324	3	venous	venous	ADJ
dti-1336	324	4	thromboembolism	thromboembolism	NOUN
dti-1336	324	5	in	in	ADP
dti-1336	324	6	users	user	NOUN
dti-1336	324	7	of	of	ADP
dti-1336	324	8	hormone	hormone	NOUN
dti-1336	324	9	replacement	replacement	NOUN
dti-1336	324	10	therapy	therapy	NOUN
dti-1336	324	11	.	.	PUNCT
dti-1336	325	1	lancet	lancet	PROPN
dti-1336	325	2	,	,	PUNCT
dti-1336	325	3	348:977–80	348:977–80	PROPN
dti-1336	325	4	.	.	PUNCT
dti-1336	326	1	[	[	X
dti-1336	326	2	48	48	NUM
dti-1336	326	3	]	]	X
dti-1336	326	4	grady	grady	PROPN
dti-1336	326	5	,	,	PUNCT
dti-1336	326	6	d.	d.	PROPN
dti-1336	326	7	and	and	CCONJ
dti-1336	326	8	furberg	furberg	PROPN
dti-1336	326	9	,	,	PUNCT
dti-1336	326	10	c.	c.	PROPN
dti-1336	326	11	1997	1997	NUM
dti-1336	326	12	.	.	PUNCT
dti-1336	327	1	venous	venous	ADJ
dti-1336	327	2	thromboembolic	thromboembolic	ADJ
dti-1336	327	3	events	event	NOUN
dti-1336	327	4	associated	associate	VERB
dti-1336	327	5	with	with	ADP
dti-1336	327	6	hormone	hormone	NOUN
dti-1336	327	7	replacement	replacement	NOUN
dti-1336	327	8	therapy	therapy	NOUN
dti-1336	327	9	.	.	PUNCT
dti-1336	328	1	jama	jama	PROPN
dti-1336	328	2	,	,	PUNCT
dti-1336	328	3	278:477	278:477	NOUN
dti-1336	328	4	.	.	PUNCT
dti-1336	329	1	[	[	X
dti-1336	329	2	49	49	NUM
dti-1336	329	3	]	]	X
dti-1336	329	4	bloemenkamp	bloemenkamp	NOUN
dti-1336	329	5	,	,	PUNCT
dti-1336	329	6	k.w.m	k.w.m	PROPN
dti-1336	329	7	.	.	PROPN
dti-1336	329	8	,	,	PUNCT
dti-1336	329	9	rosendaal	rosendaal	PROPN
dti-1336	329	10	,	,	PUNCT
dti-1336	329	11	f.r	f.r	PROPN
dti-1336	329	12	.	.	PROPN
dti-1336	329	13	,	,	PUNCT
dti-1336	329	14	helmerhorst	helmerhorst	PROPN
dti-1336	329	15	,	,	PUNCT
dti-1336	329	16	f.m	f.m	PROPN
dti-1336	329	17	.	.	PROPN
dti-1336	329	18	,	,	PUNCT
dti-1336	329	19	b.üller	b.üller	PROPN
dti-1336	329	20	,	,	PUNCT
dti-1336	329	21	h.r	h.r	PROPN
dti-1336	329	22	.	.	PROPN
dti-1336	329	23	and	and	CCONJ
dti-1336	329	24	vandenbroucke	vandenbroucke	PROPN
dti-1336	329	25	,	,	PUNCT
dti-1336	329	26	j.p	j.p	PROPN
dti-1336	329	27	.	.	PROPN
dti-1336	329	28	1995	1995	NUM
dti-1336	329	29	.	.	PUNCT
dti-1336	330	1	enhancement	enhancement	NOUN
dti-1336	330	2	by	by	ADP
dti-1336	330	3	factor	factor	NOUN
dti-1336	330	4	v	v	PROPN
dti-1336	330	5	leiden	leiden	PROPN
dti-1336	330	6	mutation	mutation	NOUN
dti-1336	330	7	of	of	ADP
dti-1336	330	8	risk	risk	NOUN
dti-1336	330	9	of	of	ADP
dti-1336	330	10	deep	deep	ADJ
dti-1336	330	11	-	-	PUNCT
dti-1336	330	12	vein	vein	NOUN
dti-1336	330	13	thrombosis	thrombosis	NOUN
dti-1336	330	14	associated	associate	VERB
dti-1336	330	15	with	with	ADP
dti-1336	330	16	oral	oral	ADJ
dti-1336	330	17	contraceptives	contraceptive	NOUN
dti-1336	330	18	containing	contain	VERB
dti-1336	330	19	a	a	DET
dti-1336	330	20	third	third	ADJ
dti-1336	330	21	-	-	PUNCT
dti-1336	330	22	generation	generation	NOUN
dti-1336	330	23	progestagen	progestagen	NOUN
dti-1336	330	24	.	.	PUNCT
dti-1336	331	1	lancet	lancet	PROPN
dti-1336	331	2	,	,	PUNCT
dti-1336	331	3	346:1593–6	346:1593–6	NUM
dti-1336	331	4	.	.	PUNCT
dti-1336	332	1	[	[	X
dti-1336	332	2	50	50	NUM
dti-1336	332	3	]	]	X
dti-1336	332	4	blom	blom	PROPN
dti-1336	332	5	,	,	PUNCT
dti-1336	332	6	j.w	j.w	PROPN
dti-1336	332	7	.	.	PROPN
dti-1336	332	8	,	,	PUNCT
dti-1336	332	9	doggen	doggen	PROPN
dti-1336	332	10	,	,	PUNCT
dti-1336	332	11	c.j	c.j	PROPN
dti-1336	332	12	.	.	PROPN
dti-1336	332	13	,	,	PUNCT
dti-1336	332	14	osanto	osanto	ADJ
dti-1336	332	15	,	,	PUNCT
dti-1336	332	16	s.	s.	PROPN
dti-1336	332	17	and	and	CCONJ
dti-1336	332	18	rosendaal	rosendaal	PROPN
dti-1336	332	19	,	,	PUNCT
dti-1336	332	20	f.r	f.r	PROPN
dti-1336	332	21	.	.	NOUN
dti-1336	332	22	2005	2005	NUM
dti-1336	332	23	.	.	PUNCT
dti-1336	333	1	malignancies	malignancy	NOUN
dti-1336	333	2	,	,	PUNCT
dti-1336	333	3	prothrombotic	prothrombotic	ADJ
dti-1336	333	4	mutations	mutation	NOUN
dti-1336	333	5	,	,	PUNCT
dti-1336	333	6	and	and	CCONJ
dti-1336	333	7	the	the	DET
dti-1336	333	8	risk	risk	NOUN
dti-1336	333	9	of	of	ADP
dti-1336	333	10	venous	venous	ADJ
dti-1336	333	11	thrombosis	thrombosis	NOUN
dti-1336	333	12	.	.	PUNCT
dti-1336	334	1	jama	jama	PROPN
dti-1336	334	2	,	,	PUNCT
dti-1336	334	3	293:715–22	293:715–22	NUM
dti-1336	334	4	.	.	PUNCT
dti-1336	335	1	[	[	X
dti-1336	335	2	51	51	NUM
dti-1336	335	3	]	]	PUNCT
dti-1336	335	4	prandoni	prandoni	NOUN
dti-1336	335	5	,	,	PUNCT
dti-1336	335	6	p.	p.	NOUN
dti-1336	335	7	,	,	PUNCT
dti-1336	335	8	lensing	lense	VERB
dti-1336	335	9	,	,	PUNCT
dti-1336	335	10	a.w	a.w	PROPN
dti-1336	335	11	.	.	PROPN
dti-1336	335	12	,	,	PUNCT
dti-1336	335	13	buller	buller	PROPN
dti-1336	335	14	,	,	PUNCT
dti-1336	335	15	h.r	h.r	PROPN
dti-1336	335	16	.	.	PROPN
dti-1336	335	17	,	,	PUNCT
dti-1336	335	18	cogo	cogo	PROPN
dti-1336	335	19	,	,	PUNCT
dti-1336	335	20	a.	a.	NOUN
dti-1336	335	21	,	,	PUNCT
dti-1336	335	22	prins	prins	PROPN
dti-1336	335	23	,	,	PUNCT
dti-1336	335	24	m.h	m.h	PROPN
dti-1336	335	25	.	.	PROPN
dti-1336	335	26	,	,	PUNCT
dti-1336	335	27	cattelan	cattelan	PROPN
dti-1336	335	28	,	,	PUNCT
dti-1336	335	29	a.m.	a.m.	ADV
dti-1336	335	30	,	,	PUNCT
dti-1336	335	31	cuppini	cuppini	PROPN
dti-1336	335	32	,	,	PUNCT
dti-1336	335	33	s.	s.	PROPN
dti-1336	335	34	,	,	PUNCT
dti-1336	335	35	noventa	noventa	PROPN
dti-1336	335	36	,	,	PUNCT
dti-1336	335	37	f.	f.	PROPN
dti-1336	335	38	and	and	CCONJ
dti-1336	335	39	ten	ten	NUM
dti-1336	335	40	cate	cate	NOUN
dti-1336	335	41	,	,	PUNCT
dti-1336	335	42	j.w	j.w	PROPN
dti-1336	335	43	.	.	PROPN
dti-1336	335	44	1992	1992	NUM
dti-1336	335	45	.	.	PUNCT
dti-1336	336	1	deep	deep	ADJ
dti-1336	336	2	-	-	PUNCT
dti-1336	336	3	vein	vein	NOUN
dti-1336	336	4	thrombosis	thrombosis	NOUN
dti-1336	336	5	and	and	CCONJ
dti-1336	336	6	incidence	incidence	NOUN
dti-1336	336	7	of	of	ADP
dti-1336	336	8	subsequent	subsequent	ADJ
dti-1336	336	9	symptomatic	symptomatic	ADJ
dti-1336	336	10	cancer	cancer	NOUN
dti-1336	336	11	.	.	PUNCT
dti-1336	337	1	n.	n.	PROPN
dti-1336	337	2	eng	eng	PROPN
dti-1336	337	3	j.	j.	PROPN
dti-1336	337	4	med	med	PROPN
dti-1336	337	5	.	.	PROPN
dti-1336	337	6	,	,	PUNCT
dti-1336	338	1	327(16):1128–33	327(16):1128–33	NUM
dti-1336	338	2	.	.	PUNCT
dti-1336	339	1	[	[	X
dti-1336	339	2	52	52	NUM
dti-1336	339	3	]	]	X
dti-1336	339	4	rickles	rickles	PROPN
dti-1336	339	5	,	,	PUNCT
dti-1336	339	6	f.r	f.r	PROPN
dti-1336	339	7	.	.	PROPN
dti-1336	339	8	,	,	PUNCT
dti-1336	339	9	patierno	patierno	ADJ
dti-1336	339	10	,	,	PUNCT
dti-1336	339	11	s.	s.	PROPN
dti-1336	339	12	and	and	CCONJ
dti-1336	339	13	fernandez	fernandez	PROPN
dti-1336	339	14	,	,	PUNCT
dti-1336	339	15	p.m.	p.m.	NOUN
dti-1336	339	16	2003	2003	NUM
dti-1336	339	17	.	.	PUNCT
dti-1336	340	1	tissue	tissue	NOUN
dti-1336	340	2	factor	factor	NOUN
dti-1336	340	3	,	,	PUNCT
dti-1336	340	4	thrombin	thrombin	NOUN
dti-1336	340	5	and	and	CCONJ
dti-1336	340	6	cancer	cancer	NOUN
dti-1336	340	7	.	.	PUNCT
dti-1336	341	1	chest	chest	NOUN
dti-1336	341	2	(	(	PUNCT
dti-1336	341	3	supplement	supplement	NOUN
dti-1336	341	4	)	)	PUNCT
dti-1336	341	5	,	,	PUNCT
dti-1336	341	6	124:58s–68s	124:58s–68s	NUM
dti-1336	341	7	.	.	NOUN
dti-1336	341	8	97	97	NUM
dti-1336	341	9	thrombophilia	thrombophilia	PROPN
dti-1336	341	10	drug	drug	NOUN
dti-1336	341	11	target	target	NOUN
dti-1336	341	12	insights	insight	NOUN
dti-1336	341	13	2008:3	2008:3	NUM
dti-1336	341	14	[	[	X
dti-1336	341	15	53	53	NUM
dti-1336	341	16	]	]	X
dti-1336	341	17	koizume	koizume	PROPN
dti-1336	341	18	,	,	PUNCT
dti-1336	341	19	s.	s.	PROPN
dti-1336	341	20	,	,	PUNCT
dti-1336	341	21	jin	jin	NOUN
dti-1336	341	22	,	,	PUNCT
dti-1336	341	23	m.	m.	NOUN
dti-1336	341	24	,	,	PUNCT
dti-1336	341	25	miyagi	miyagi	PROPN
dti-1336	341	26	,	,	PUNCT
dti-1336	341	27	e.	e.	PROPN
dti-1336	341	28	et	et	PROPN
dti-1336	341	29	al	al	PROPN
dti-1336	341	30	.	.	PROPN
dti-1336	341	31	2006	2006	NUM
dti-1336	341	32	.	.	PUNCT
dti-1336	342	1	activation	activation	NOUN
dti-1336	342	2	of	of	ADP
dti-1336	342	3	cancer	cancer	NOUN
dti-1336	342	4	cells	cell	NOUN
dti-1336	342	5	migration	migration	NOUN
dti-1336	342	6	and	and	CCONJ
dti-1336	342	7	invasion	invasion	NOUN
dti-1336	342	8	by	by	ADP
dti-1336	342	9	ectopic	ectopic	ADJ
dti-1336	342	10	synthesis	synthesis	NOUN
dti-1336	342	11	of	of	ADP
dti-1336	342	12	coagulation	coagulation	NOUN
dti-1336	342	13	factor	factor	NOUN
dti-1336	342	14	vii	vii	PROPN
dti-1336	342	15	.	.	PUNCT
dti-1336	343	1	cancer	cancer	NOUN
dti-1336	343	2	res	re	NOUN
dti-1336	343	3	.	.	PUNCT
dti-1336	343	4	,	,	PUNCT
dti-1336	343	5	66:9453–60	66:9453–60	NOUN
dti-1336	343	6	.	.	PUNCT
dti-1336	344	1	[	[	X
dti-1336	344	2	54	54	NUM
dti-1336	344	3	]	]	X
dti-1336	344	4	callander	callander	NOUN
dti-1336	344	5	,	,	PUNCT
dti-1336	344	6	n.s	n.s	PROPN
dti-1336	344	7	.	.	PROPN
dti-1336	344	8	,	,	PUNCT
dti-1336	344	9	varki	varki	NOUN
dti-1336	344	10	,	,	PUNCT
dti-1336	344	11	n.	n.	NOUN
dti-1336	344	12	and	and	CCONJ
dti-1336	344	13	rao	rao	PROPN
dti-1336	344	14	,	,	PUNCT
dti-1336	344	15	l.v.m	l.v.m	NOUN
dti-1336	344	16	.	.	PUNCT
dti-1336	344	17	1992	1992	NUM
dti-1336	344	18	.	.	PUNCT
dti-1336	345	1	immunohistochemical	immunohistochemical	ADJ
dti-1336	345	2	identifi	identifi	PROPN
dti-1336	345	3	cation	cation	NOUN
dti-1336	345	4	of	of	ADP
dti-1336	345	5	tissue	tissue	NOUN
dti-1336	345	6	factor	factor	NOUN
dti-1336	345	7	in	in	ADP
dti-1336	345	8	solid	solid	ADJ
dti-1336	345	9	tumors	tumor	NOUN
dti-1336	345	10	.	.	PUNCT
dti-1336	346	1	cancer	cancer	NOUN
dti-1336	346	2	,	,	PUNCT
dti-1336	346	3	70:1194–201	70:1194–201	NUM
dti-1336	346	4	.	.	PUNCT
dti-1336	347	1	[	[	X
dti-1336	347	2	55	55	NUM
dti-1336	347	3	]	]	SYM
dti-1336	347	4	rong	rong	PROPN
dti-1336	347	5	,	,	PUNCT
dti-1336	347	6	y.	y.	PROPN
dti-1336	347	7	,	,	PUNCT
dti-1336	347	8	post	post	NOUN
dti-1336	347	9	,	,	PUNCT
dti-1336	347	10	d.e	d.e	PROPN
dti-1336	347	11	.	.	PROPN
dti-1336	347	12	,	,	PUNCT
dti-1336	347	13	pieper	pieper	PROPN
dti-1336	347	14	,	,	PUNCT
dti-1336	347	15	r.o	r.o	PROPN
dti-1336	347	16	.	.	PROPN
dti-1336	347	17	et	et	PROPN
dti-1336	347	18	al	al	PROPN
dti-1336	347	19	.	.	PROPN
dti-1336	347	20	2005	2005	NUM
dti-1336	347	21	.	.	PUNCT
dti-1336	347	22	pten	pten	VERB
dti-1336	347	23	.	.	PUNCT
dti-1336	348	1	and	and	CCONJ
dti-1336	348	2	hypoxia	hypoxia	NOUN
dti-1336	348	3	regulate	regulate	NOUN
dti-1336	348	4	tissue	tissue	NOUN
dti-1336	348	5	factor	factor	NOUN
dti-1336	348	6	expression	expression	NOUN
dti-1336	348	7	and	and	CCONJ
dti-1336	348	8	plasma	plasma	NOUN
dti-1336	348	9	coagulation	coagulation	NOUN
dti-1336	348	10	by	by	ADP
dti-1336	348	11	glioblastoma	glioblastoma	NOUN
dti-1336	348	12	.	.	PUNCT
dti-1336	349	1	cancer	cancer	NOUN
dti-1336	349	2	res	re	NOUN
dti-1336	349	3	.	.	PROPN
dti-1336	349	4	,	,	PUNCT
dti-1336	349	5	65:1406–13	65:1406–13	NUM
dti-1336	349	6	.	.	PUNCT
dti-1336	350	1	[	[	X
dti-1336	350	2	56	56	NUM
dti-1336	350	3	]	]	X
dti-1336	350	4	fernandez	fernandez	PROPN
dti-1336	350	5	,	,	PUNCT
dti-1336	350	6	p.m.	p.m.	NOUN
dti-1336	350	7	,	,	PUNCT
dti-1336	350	8	patierno	patierno	ADJ
dti-1336	350	9	,	,	PUNCT
dti-1336	350	10	s.r	s.r	PROPN
dti-1336	350	11	.	.	PROPN
dti-1336	350	12	and	and	CCONJ
dti-1336	350	13	rickles	rickles	PROPN
dti-1336	350	14	,	,	PUNCT
dti-1336	350	15	f.r	f.r	PROPN
dti-1336	350	16	.	.	NOUN
dti-1336	350	17	2004	2004	NUM
dti-1336	350	18	.	.	PUNCT
dti-1336	351	1	tissue	tissue	NOUN
dti-1336	351	2	factor	factor	NOUN
dti-1336	351	3	and	and	CCONJ
dti-1336	351	4	fi	fi	NOUN
dti-1336	351	5	brin	brin	NOUN
dti-1336	351	6	in	in	ADP
dti-1336	351	7	tumor	tumor	PROPN
dti-1336	351	8	angiogenesis	angiogenesis	PROPN
dti-1336	351	9	.	.	PUNCT
dti-1336	352	1	semin	semin	PROPN
dti-1336	352	2	.	.	PUNCT
dti-1336	353	1	thromb	thromb	PROPN
dti-1336	353	2	.	.	PUNCT
dti-1336	354	1	hemost	hemost	PROPN
dti-1336	354	2	.	.	PUNCT
dti-1336	355	1	,	,	PUNCT
dti-1336	355	2	30:31–44	30:31–44	NUM
dti-1336	355	3	.	.	PUNCT
dti-1336	356	1	[	[	X
dti-1336	356	2	57	57	NUM
dti-1336	356	3	]	]	X
dti-1336	356	4	fernandez	fernandez	PROPN
dti-1336	356	5	,	,	PUNCT
dti-1336	356	6	p.m.	p.m.	NOUN
dti-1336	356	7	and	and	CCONJ
dti-1336	356	8	rickles	rickles	PROPN
dti-1336	356	9	,	,	PUNCT
dti-1336	356	10	f.r	f.r	PROPN
dti-1336	356	11	.	.	NOUN
dti-1336	356	12	2002	2002	NUM
dti-1336	356	13	.	.	PUNCT
dti-1336	356	14	tissue	tissue	NOUN
dti-1336	356	15	factor	factor	NOUN
dti-1336	356	16	and	and	CCONJ
dti-1336	356	17	angiogenesis	angiogenesis	NOUN
dti-1336	356	18	in	in	ADP
dti-1336	356	19	cancer	cancer	NOUN
dti-1336	356	20	.	.	PUNCT
dti-1336	357	1	curr	curr	PROPN
dti-1336	357	2	.	.	PUNCT
dti-1336	358	1	opin	opin	NOUN
dti-1336	358	2	.	.	PUNCT
dti-1336	359	1	hematol	hematol	NOUN
dti-1336	359	2	.	.	PUNCT
dti-1336	359	3	,	,	PUNCT
dti-1336	360	1	9:401–6	9:401–6	X
dti-1336	360	2	.	.	PUNCT
dti-1336	361	1	[	[	X
dti-1336	361	2	58	58	NUM
dti-1336	361	3	]	]	X
dti-1336	361	4	rak	rak	PROPN
dti-1336	361	5	,	,	PUNCT
dti-1336	361	6	j.	j.	PROPN
dti-1336	361	7	,	,	PUNCT
dti-1336	361	8	yu	yu	PROPN
dti-1336	361	9	,	,	PUNCT
dti-1336	361	10	j.l	j.l	PROPN
dti-1336	361	11	.	.	PROPN
dti-1336	361	12	,	,	PUNCT
dti-1336	361	13	luyendyk	luyendyk	PROPN
dti-1336	361	14	,	,	PUNCT
dti-1336	361	15	j.	j.	PROPN
dti-1336	361	16	et	et	PROPN
dti-1336	361	17	al	al	PROPN
dti-1336	361	18	.	.	PROPN
dti-1336	361	19	2006	2006	NUM
dti-1336	361	20	.	.	PUNCT
dti-1336	362	1	oncogenes	oncogene	NOUN
dti-1336	362	2	,	,	PUNCT
dti-1336	362	3	trousseau	trousseau	NOUN
dti-1336	362	4	syndrome	syndrome	NOUN
dti-1336	362	5	,	,	PUNCT
dti-1336	362	6	and	and	CCONJ
dti-1336	362	7	cancer	cancer	NOUN
dti-1336	362	8	-	-	PUNCT
dti-1336	362	9	related	relate	VERB
dti-1336	362	10	changes	change	NOUN
dti-1336	362	11	in	in	ADP
dti-1336	362	12	the	the	DET
dti-1336	362	13	coagulome	coagulome	NOUN
dti-1336	362	14	of	of	ADP
dti-1336	362	15	mice	mouse	NOUN
dti-1336	362	16	and	and	CCONJ
dti-1336	362	17	humans	human	NOUN
dti-1336	362	18	.	.	PUNCT
dti-1336	363	1	cancer	cancer	NOUN
dti-1336	363	2	res	re	NOUN
dti-1336	363	3	.	.	PUNCT
dti-1336	363	4	,	,	PUNCT
dti-1336	364	1	66:10643–6	66:10643–6	NUM
dti-1336	364	2	.	.	PUNCT
dti-1336	365	1	[	[	X
dti-1336	365	2	59	59	NUM
dti-1336	365	3	]	]	X
dti-1336	365	4	boccaccio	boccaccio	PROPN
dti-1336	365	5	,	,	PUNCT
dti-1336	365	6	c.	c.	PROPN
dti-1336	365	7	,	,	PUNCT
dti-1336	365	8	sabatino	sabatino	PROPN
dti-1336	365	9	,	,	PUNCT
dti-1336	365	10	g.	g.	PROPN
dti-1336	365	11	,	,	PUNCT
dti-1336	365	12	medico	medico	PROPN
dti-1336	365	13	,	,	PUNCT
dti-1336	365	14	e.	e.	PROPN
dti-1336	365	15	et	et	PROPN
dti-1336	365	16	al	al	PROPN
dti-1336	365	17	.	.	PROPN
dti-1336	365	18	2005	2005	NUM
dti-1336	365	19	.	.	PUNCT
dti-1336	366	1	the	the	PRON
dti-1336	366	2	met	meet	VERB
dti-1336	366	3	oncogene	oncogene	NOUN
dti-1336	366	4	drives	drive	VERB
dti-1336	366	5	a	a	DET
dti-1336	366	6	genetic	genetic	ADJ
dti-1336	366	7	programme	programme	NOUN
dti-1336	366	8	linking	link	VERB
dti-1336	366	9	cancer	cancer	NOUN
dti-1336	366	10	to	to	ADP
dti-1336	366	11	haemostasis	haemostasis	VERB
dti-1336	366	12	.	.	PUNCT
dti-1336	367	1	nature	nature	NOUN
dti-1336	367	2	,	,	PUNCT
dti-1336	367	3	434:396–400	434:396–400	NOUN
dti-1336	367	4	.	.	PUNCT
dti-1336	368	1	[	[	X
dti-1336	368	2	60	60	NUM
dti-1336	368	3	]	]	X
dti-1336	368	4	palumbo	palumbo	PROPN
dti-1336	368	5	,	,	PUNCT
dti-1336	368	6	j.s	j.s	PROPN
dti-1336	368	7	.	.	PROPN
dti-1336	368	8	,	,	PUNCT
dti-1336	368	9	talmage	talmage	NOUN
dti-1336	368	10	,	,	PUNCT
dti-1336	368	11	k.e	k.e	PROPN
dti-1336	368	12	.	.	PROPN
dti-1336	368	13	,	,	PUNCT
dti-1336	368	14	massari	massari	PROPN
dti-1336	368	15	,	,	PUNCT
dti-1336	368	16	j.v	j.v	PROPN
dti-1336	368	17	.	.	PROPN
dti-1336	368	18	et	et	PROPN
dti-1336	368	19	al	al	PROPN
dti-1336	368	20	.	.	PROPN
dti-1336	368	21	2005	2005	NUM
dti-1336	368	22	.	.	PUNCT
dti-1336	369	1	platelets	platelet	NOUN
dti-1336	369	2	and	and	CCONJ
dti-1336	369	3	fi	fi	NOUN
dti-1336	369	4	brin(ogen	brin(ogen	NOUN
dti-1336	369	5	)	)	PUNCT
dti-1336	369	6	increase	increase	NOUN
dti-1336	369	7	metastatic	metastatic	ADJ
dti-1336	369	8	potential	potential	NOUN
dti-1336	369	9	by	by	ADP
dti-1336	369	10	pmpeding	pmpede	VERB
dti-1336	369	11	natural	natural	ADJ
dti-1336	369	12	killer	killer	NOUN
dti-1336	369	13	cell	cell	NOUN
dti-1336	369	14	-	-	PUNCT
dti-1336	369	15	mediated	mediate	VERB
dti-1336	369	16	elimination	elimination	NOUN
dti-1336	369	17	of	of	ADP
dti-1336	369	18	tumor	tumor	NOUN
dti-1336	369	19	cells	cell	NOUN
dti-1336	369	20	.	.	PUNCT
dti-1336	370	1	blood	blood	NOUN
dti-1336	370	2	,	,	PUNCT
dti-1336	370	3	178–85	178–85	NUM
dti-1336	370	4	.	.	PUNCT
dti-1336	371	1	[	[	X
dti-1336	371	2	61	61	NUM
dti-1336	371	3	]	]	SYM
dti-1336	371	4	tosetto	tosetto	NOUN
dti-1336	371	5	,	,	PUNCT
dti-1336	371	6	a.	a.	NOUN
dti-1336	371	7	,	,	PUNCT
dti-1336	371	8	missiaglia	missiaglia	PROPN
dti-1336	371	9	,	,	PUNCT
dti-1336	371	10	e.	e.	PROPN
dti-1336	371	11	,	,	PUNCT
dti-1336	371	12	gatto	gatto	PROPN
dti-1336	371	13	,	,	PUNCT
dti-1336	371	14	e.	e.	PROPN
dti-1336	371	15	and	and	CCONJ
dti-1336	371	16	rodeghiero	rodeghiero	PROPN
dti-1336	371	17	,	,	PUNCT
dti-1336	371	18	f.	f.	PROPN
dti-1336	371	19	1997	1997	NUM
dti-1336	371	20	.	.	PUNCT
dti-1336	372	1	the	the	DET
dti-1336	372	2	vita	vita	NOUN
dti-1336	372	3	project	project	NOUN
dti-1336	372	4	:	:	PUNCT
dti-1336	372	5	phenotypic	phenotypic	ADJ
dti-1336	372	6	resistance	resistance	NOUN
dti-1336	372	7	to	to	ADP
dti-1336	372	8	activated	activate	VERB
dti-1336	372	9	protein	protein	NOUN
dti-1336	372	10	c	c	NOUN
dti-1336	372	11	and	and	CCONJ
dti-1336	372	12	fv	fv	PROPN
dti-1336	372	13	leiden	leiden	PROPN
dti-1336	372	14	mutation	mutation	NOUN
dti-1336	372	15	in	in	ADP
dti-1336	372	16	the	the	DET
dti-1336	372	17	general	general	ADJ
dti-1336	372	18	population	population	NOUN
dti-1336	372	19	.	.	PUNCT
dti-1336	373	1	vicenza	vicenza	PROPN
dti-1336	373	2	thrombophilia	thrombophilia	NOUN
dti-1336	373	3	and	and	CCONJ
dti-1336	373	4	atherosclerosis	atherosclerosis	NOUN
dti-1336	373	5	.	.	PUNCT
dti-1336	374	1	thromb	thromb	NOUN
dti-1336	374	2	.	.	PUNCT
dti-1336	375	1	haemost	haemost	PROPN
dti-1336	375	2	,	,	PUNCT
dti-1336	375	3	78(2):859–63	78(2):859–63	NUM
dti-1336	375	4	.	.	PUNCT
dti-1336	376	1	[	[	X
dti-1336	376	2	62	62	NUM
dti-1336	376	3	]	]	X
dti-1336	376	4	de	de	X
dti-1336	376	5	visser	visser	PROPN
dti-1336	376	6	,	,	PUNCT
dti-1336	376	7	m.c	m.c	PROPN
dti-1336	376	8	.	.	PROPN
dti-1336	376	9	,	,	PUNCT
dti-1336	376	10	rosendaal	rosendaal	PROPN
dti-1336	376	11	,	,	PUNCT
dti-1336	376	12	f.r	f.r	PROPN
dti-1336	376	13	.	.	PROPN
dti-1336	376	14	and	and	CCONJ
dti-1336	376	15	bertina	bertina	PROPN
dti-1336	376	16	,	,	PUNCT
dti-1336	376	17	r.m	r.m	PROPN
dti-1336	376	18	.	.	PROPN
dti-1336	376	19	1999	1999	NUM
dti-1336	376	20	.	.	PUNCT
dti-1336	377	1	a	a	DET
dti-1336	377	2	reduced	reduce	VERB
dti-1336	377	3	sensitivity	sensitivity	NOUN
dti-1336	377	4	for	for	ADP
dti-1336	377	5	activated	activated	ADJ
dti-1336	377	6	protein	protein	NOUN
dti-1336	377	7	c	c	NOUN
dti-1336	377	8	in	in	ADP
dti-1336	377	9	the	the	DET
dti-1336	377	10	absence	absence	NOUN
dti-1336	377	11	of	of	ADP
dti-1336	377	12	factor	factor	NOUN
dti-1336	377	13	v	v	PROPN
dti-1336	377	14	leiden	leiden	PROPN
dti-1336	377	15	increases	increase	VERB
dti-1336	377	16	the	the	DET
dti-1336	377	17	risk	risk	NOUN
dti-1336	377	18	of	of	ADP
dti-1336	377	19	venous	venous	ADJ
dti-1336	377	20	thrombosis	thrombosis	NOUN
dti-1336	377	21	.	.	PUNCT
dti-1336	378	1	blood	blood	NOUN
dti-1336	378	2	,	,	PUNCT
dti-1336	378	3	93:1271–6	93:1271–6	NUM
dti-1336	378	4	.	.	PUNCT
dti-1336	379	1	[	[	X
dti-1336	379	2	63	63	NUM
dti-1336	379	3	]	]	SYM
dti-1336	379	4	rodeghiero	rodeghiero	NOUN
dti-1336	379	5	,	,	PUNCT
dti-1336	379	6	f.	f.	PROPN
dti-1336	379	7	and	and	CCONJ
dti-1336	379	8	tosetto	tosetto	PROPN
dti-1336	379	9	,	,	PUNCT
dti-1336	379	10	a.	a.	NOUN
dti-1336	379	11	1999	1999	NUM
dti-1336	379	12	.	.	PUNCT
dti-1336	380	1	activated	activate	VERB
dti-1336	380	2	protein	protein	NOUN
dti-1336	380	3	c	c	NOUN
dti-1336	380	4	resistance	resistance	NOUN
dti-1336	380	5	and	and	CCONJ
dti-1336	380	6	factor	factor	NOUN
dti-1336	380	7	v	v	PROPN
dti-1336	380	8	leiden	leiden	PROPN
dti-1336	380	9	mutation	mutation	NOUN
dti-1336	380	10	are	be	AUX
dti-1336	380	11	independent	independent	ADJ
dti-1336	380	12	risk	risk	NOUN
dti-1336	380	13	factors	factor	NOUN
dti-1336	380	14	for	for	ADP
dti-1336	380	15	venous	venous	ADJ
dti-1336	380	16	thromboembolism	thromboembolism	NOUN
dti-1336	380	17	.	.	PUNCT
dti-1336	381	1	annals	annal	NOUN
dti-1336	381	2	.	.	PUNCT
dti-1336	382	1	intern	intern	PROPN
dti-1336	382	2	.	.	PUNCT
dti-1336	383	1	med	med	PROPN
dti-1336	383	2	.	.	PROPN
dti-1336	383	3	,	,	PUNCT
dti-1336	383	4	130:643–50	130:643–50	NUM
dti-1336	383	5	.	.	PUNCT
dti-1336	384	1	[	[	X
dti-1336	384	2	64	64	NUM
dti-1336	384	3	]	]	X
dti-1336	384	4	van	van	PROPN
dti-1336	384	5	der	der	PROPN
dti-1336	384	6	bom	bom	PROPN
dti-1336	384	7	,	,	PUNCT
dti-1336	384	8	j.g	j.g	PROPN
dti-1336	384	9	.	.	PROPN
dti-1336	384	10	,	,	PUNCT
dti-1336	384	11	bots	bot	NOUN
dti-1336	384	12	,	,	PUNCT
dti-1336	384	13	m.l	m.l	PROPN
dti-1336	384	14	.	.	PROPN
dti-1336	384	15	,	,	PUNCT
dti-1336	384	16	haverkate	haverkate	PROPN
dti-1336	384	17	,	,	PUNCT
dti-1336	384	18	f.	f.	PROPN
dti-1336	384	19	,	,	PUNCT
dti-1336	384	20	slagboom	slagboom	PROPN
dti-1336	384	21	,	,	PUNCT
dti-1336	384	22	p.e	p.e	PROPN
dti-1336	384	23	.	.	PROPN
dti-1336	384	24	,	,	PUNCT
dti-1336	384	25	meijer	meijer	PROPN
dti-1336	384	26	,	,	PUNCT
dti-1336	384	27	p.	p.	PROPN
dti-1336	384	28	,	,	PUNCT
dti-1336	384	29	de	de	PROPN
dti-1336	384	30	jong	jong	PROPN
dti-1336	384	31	,	,	PUNCT
dti-1336	384	32	p.t	p.t	PROPN
dti-1336	384	33	.	.	PROPN
dti-1336	384	34	,	,	PUNCT
dti-1336	384	35	hofman	hofman	PROPN
dti-1336	384	36	,	,	PUNCT
dti-1336	384	37	a.	a.	NOUN
dti-1336	384	38	,	,	PUNCT
dti-1336	384	39	grobbee	grobbee	PROPN
dti-1336	384	40	,	,	PUNCT
dti-1336	384	41	d.e	d.e	PROPN
dti-1336	384	42	.	.	PROPN
dti-1336	384	43	et	et	PROPN
dti-1336	384	44	al	al	PROPN
dti-1336	384	45	.	.	PROPN
dti-1336	384	46	1996	1996	NUM
dti-1336	384	47	.	.	PUNCT
dti-1336	385	1	reduced	reduce	VERB
dti-1336	385	2	reponse	reponse	NOUN
dti-1336	385	3	to	to	ADP
dti-1336	385	4	activated	activated	ADJ
dti-1336	385	5	protein	protein	NOUN
dti-1336	385	6	c	c	NOUN
dti-1336	385	7	is	be	AUX
dti-1336	385	8	associated	associate	VERB
dti-1336	385	9	with	with	ADP
dti-1336	385	10	increased	increase	VERB
dti-1336	385	11	risk	risk	NOUN
dti-1336	385	12	for	for	ADP
dti-1336	385	13	cerebrovascular	cerebrovascular	ADJ
dti-1336	385	14	disease	disease	NOUN
dti-1336	385	15	.	.	PUNCT
dti-1336	386	1	ann	ann	PROPN
dti-1336	386	2	.	.	PUNCT
dti-1336	386	3	intern	intern	PROPN
dti-1336	386	4	.	.	PUNCT
dti-1336	387	1	med	med	PROPN
dti-1336	387	2	.	.	PROPN
dti-1336	387	3	,	,	PUNCT
dti-1336	387	4	125:265–9	125:265–9	NUM
dti-1336	387	5	.	.	PUNCT
dti-1336	388	1	[	[	X
dti-1336	388	2	65	65	NUM
dti-1336	388	3	]	]	X
dti-1336	388	4	clark	clark	NOUN
dti-1336	388	5	,	,	PUNCT
dti-1336	388	6	p.	p.	PROPN
dti-1336	388	7	,	,	PUNCT
dti-1336	388	8	sattar	sattar	PROPN
dti-1336	388	9	,	,	PUNCT
dti-1336	388	10	n.	n.	PROPN
dti-1336	388	11	,	,	PUNCT
dti-1336	388	12	walker	walker	PROPN
dti-1336	388	13	,	,	PUNCT
dti-1336	388	14	i.d	i.d	PROPN
dti-1336	388	15	.	.	PROPN
dti-1336	388	16	and	and	CCONJ
dti-1336	388	17	greer	greer	PROPN
dti-1336	388	18	,	,	PUNCT
dti-1336	388	19	i.a	i.a	PROPN
dti-1336	388	20	.	.	PROPN
dti-1336	388	21	2001a	2001a	NOUN
dti-1336	388	22	.	.	PUNCT
dti-1336	389	1	the	the	DET
dti-1336	389	2	glasgow	glasgow	PROPN
dti-1336	389	3	outcome	outcome	NOUN
dti-1336	389	4	,	,	PUNCT
dti-1336	389	5	apcr	apcr	ADJ
dti-1336	389	6	.	.	PUNCT
dti-1336	390	1	and	and	CCONJ
dti-1336	390	2	lipid	lipid	NOUN
dti-1336	390	3	(	(	PUNCT
dti-1336	390	4	goal	goal	NOUN
dti-1336	390	5	)	)	PUNCT
dti-1336	390	6	pregnancy	pregnancy	NOUN
dti-1336	390	7	study	study	NOUN
dti-1336	390	8	:	:	PUNCT
dti-1336	390	9	signifi	signifi	PROPN
dti-1336	390	10	cance	cance	NOUN
dti-1336	390	11	of	of	ADP
dti-1336	390	12	pregnancy	pregnancy	NOUN
dti-1336	390	13	associated	associate	VERB
dti-1336	390	14	activated	activate	VERB
dti-1336	390	15	protein	protein	NOUN
dti-1336	390	16	c	c	NOUN
dti-1336	390	17	resistance	resistance	NOUN
dti-1336	390	18	.	.	PUNCT
dti-1336	391	1	thromb	thromb	NOUN
dti-1336	391	2	.	.	PUNCT
dti-1336	392	1	haemost	haemost	VERB
dti-1336	392	2	,	,	PUNCT
dti-1336	392	3	85(1):30–5	85(1):30–5	NOUN
dti-1336	392	4	.	.	PUNCT
dti-1336	393	1	[	[	X
dti-1336	393	2	66	66	NUM
dti-1336	393	3	]	]	PUNCT
dti-1336	393	4	clark	clark	NOUN
dti-1336	393	5	,	,	PUNCT
dti-1336	393	6	p.	p.	NOUN
dti-1336	393	7	and	and	CCONJ
dti-1336	393	8	walker	walker	PROPN
dti-1336	393	9	,	,	PUNCT
dti-1336	393	10	i.d	i.d	PROPN
dti-1336	393	11	.	.	PROPN
dti-1336	393	12	2001b	2001b	NUM
dti-1336	393	13	.	.	PUNCT
dti-1336	394	1	the	the	DET
dti-1336	394	2	phenomenon	phenomenon	NOUN
dti-1336	394	3	known	know	VERB
dti-1336	394	4	as	as	ADP
dti-1336	394	5	acquired	acquire	VERB
dti-1336	394	6	activated	activated	ADJ
dti-1336	394	7	protein	protein	NOUN
dti-1336	394	8	c	c	NOUN
dti-1336	394	9	resistance	resistance	NOUN
dti-1336	394	10	.	.	PUNCT
dti-1336	395	1	br	br	PROPN
dti-1336	395	2	.	.	PUNCT
dti-1336	396	1	j.	j.	PROPN
dti-1336	396	2	haematol	haematol	PROPN
dti-1336	396	3	.	.	PUNCT
dti-1336	396	4	,	,	PUNCT
dti-1336	396	5	115(4):767–73	115(4):767–73	NUM
dti-1336	396	6	.	.	PUNCT
dti-1336	397	1	[	[	X
dti-1336	397	2	67	67	NUM
dti-1336	397	3	]	]	X
dti-1336	397	4	green	green	PROPN
dti-1336	397	5	,	,	PUNCT
dti-1336	397	6	d.	d.	PROPN
dti-1336	397	7	,	,	PUNCT
dti-1336	397	8	maliekel	maliekel	PROPN
dti-1336	397	9	,	,	PUNCT
dti-1336	397	10	k.	k.	PROPN
dti-1336	397	11	,	,	PUNCT
dti-1336	397	12	sushko	sushko	PROPN
dti-1336	397	13	,	,	PUNCT
dti-1336	397	14	e.	e.	PROPN
dti-1336	397	15	,	,	PUNCT
dti-1336	397	16	akhtar	akhtar	PROPN
dti-1336	397	17	,	,	PUNCT
dti-1336	397	18	r.	r.	PROPN
dti-1336	397	19	and	and	CCONJ
dti-1336	397	20	soff	soff	NOUN
dti-1336	397	21	,	,	PUNCT
dti-1336	397	22	g.a	g.a	PROPN
dti-1336	397	23	.	.	PROPN
dti-1336	397	24	1997	1997	NUM
dti-1336	397	25	.	.	PUNCT
dti-1336	398	1	activated	activate	VERB
dti-1336	398	2	-	-	PUNCT
dti-1336	398	3	protein	protein	NOUN
dti-1336	398	4	-	-	PUNCT
dti-1336	398	5	c	c	NOUN
dti-1336	398	6	resistance	resistance	NOUN
dti-1336	398	7	in	in	ADP
dti-1336	398	8	cancer	cancer	NOUN
dti-1336	398	9	patients	patient	NOUN
dti-1336	398	10	.	.	PUNCT
dti-1336	399	1	haemostasis	haemostasis	NOUN
dti-1336	399	2	,	,	PUNCT
dti-1336	399	3	27(3):112–8	27(3):112–8	NUM
dti-1336	399	4	.	.	PUNCT
dti-1336	400	1	[	[	X
dti-1336	400	2	68	68	NUM
dti-1336	400	3	]	]	X
dti-1336	400	4	haim	haim	NOUN
dti-1336	400	5	,	,	PUNCT
dti-1336	400	6	n.	n.	NOUN
dti-1336	400	7	,	,	PUNCT
dti-1336	400	8	lanir	lanir	PROPN
dti-1336	400	9	,	,	PUNCT
dti-1336	400	10	n.	n.	NOUN
dti-1336	400	11	,	,	PUNCT
dti-1336	400	12	hoffman	hoffman	PROPN
dti-1336	400	13	,	,	PUNCT
dti-1336	400	14	r.	r.	PROPN
dti-1336	400	15	,	,	PUNCT
dti-1336	400	16	haim	haim	PROPN
dti-1336	400	17	,	,	PUNCT
dti-1336	400	18	a.	a.	PROPN
dti-1336	400	19	,	,	PUNCT
dti-1336	400	20	tsalik	tsalik	PROPN
dti-1336	400	21	,	,	PUNCT
dti-1336	400	22	m.	m.	NOUN
dti-1336	400	23	and	and	CCONJ
dti-1336	400	24	brenner	brenner	PROPN
dti-1336	400	25	,	,	PUNCT
dti-1336	400	26	b.	b.	PROPN
dti-1336	400	27	2001	2001	NUM
dti-1336	400	28	.	.	PUNCT
dti-1336	400	29	acquired	acquire	VERB
dti-1336	400	30	activated	activated	ADJ
dti-1336	400	31	protein	protein	NOUN
dti-1336	400	32	c	c	NOUN
dti-1336	400	33	resistance	resistance	NOUN
dti-1336	400	34	is	be	AUX
dti-1336	400	35	common	common	ADJ
dti-1336	400	36	in	in	ADP
dti-1336	400	37	cancer	cancer	NOUN
dti-1336	400	38	patients	patient	NOUN
dti-1336	400	39	and	and	CCONJ
dti-1336	400	40	is	be	AUX
dti-1336	400	41	associated	associate	VERB
dti-1336	400	42	with	with	ADP
dti-1336	400	43	venous	venous	ADJ
dti-1336	400	44	thromboembolism	thromboembolism	NOUN
dti-1336	400	45	.	.	PUNCT
dti-1336	401	1	am	be	AUX
dti-1336	401	2	.	.	PUNCT
dti-1336	402	1	j.	j.	PROPN
dti-1336	402	2	med	med	PROPN
dti-1336	402	3	.	.	PROPN
dti-1336	402	4	,	,	PUNCT
dti-1336	403	1	110(2):91–6	110(2):91–6	X
dti-1336	403	2	.	.	PUNCT
dti-1336	404	1	[	[	X
dti-1336	404	2	69	69	NUM
dti-1336	404	3	]	]	X
dti-1336	404	4	zangari	zangari	PROPN
dti-1336	404	5	,	,	PUNCT
dti-1336	404	6	m.	m.	NOUN
dti-1336	404	7	,	,	PUNCT
dti-1336	404	8	saghafi	saghafi	VERB
dti-1336	404	9	far	far	ADV
dti-1336	404	10	,	,	PUNCT
dti-1336	404	11	f.	f.	PROPN
dti-1336	404	12	,	,	PUNCT
dti-1336	404	13	anaissie	anaissie	PROPN
dti-1336	404	14	,	,	PUNCT
dti-1336	404	15	e.	e.	PROPN
dti-1336	404	16	,	,	PUNCT
dti-1336	404	17	badros	badros	PROPN
dti-1336	404	18	,	,	PUNCT
dti-1336	404	19	a.	a.	PROPN
dti-1336	404	20	,	,	PUNCT
dti-1336	404	21	desikan	desikan	PROPN
dti-1336	404	22	,	,	PUNCT
dti-1336	404	23	r.	r.	PROPN
dti-1336	404	24	,	,	PUNCT
dti-1336	404	25	fassas	fassa	NOUN
dti-1336	404	26	,	,	PUNCT
dti-1336	404	27	a.	a.	NOUN
dti-1336	404	28	,	,	PUNCT
dti-1336	404	29	mehta	mehta	PROPN
dti-1336	404	30	,	,	PUNCT
dti-1336	404	31	p.	p.	PROPN
dti-1336	404	32	,	,	PUNCT
dti-1336	404	33	morris	morris	PROPN
dti-1336	404	34	,	,	PUNCT
dti-1336	404	35	c.	c.	PROPN
dti-1336	404	36	,	,	PUNCT
dti-1336	404	37	toor	toor	PROPN
dti-1336	404	38	,	,	PUNCT
dti-1336	404	39	a.	a.	PROPN
dti-1336	404	40	,	,	PUNCT
dti-1336	404	41	whitfi	whitfi	PROPN
dti-1336	404	42	eld	eld	PROPN
dti-1336	404	43	,	,	PUNCT
dti-1336	404	44	d.	d.	PROPN
dti-1336	404	45	,	,	PUNCT
dti-1336	404	46	siegel	siegel	PROPN
dti-1336	404	47	,	,	PUNCT
dti-1336	404	48	e.	e.	PROPN
dti-1336	404	49	,	,	PUNCT
dti-1336	404	50	barlogie	barlogie	PROPN
dti-1336	404	51	,	,	PUNCT
dti-1336	404	52	b.	b.	PROPN
dti-1336	404	53	,	,	PUNCT
dti-1336	404	54	fink	fink	PROPN
dti-1336	404	55	,	,	PUNCT
dti-1336	404	56	l.	l.	PROPN
dti-1336	404	57	and	and	CCONJ
dti-1336	404	58	tricot	tricot	NOUN
dti-1336	404	59	,	,	PUNCT
dti-1336	404	60	g.	g.	PROPN
dti-1336	404	61	2002	2002	NUM
dti-1336	404	62	.	.	PUNCT
dti-1336	405	1	activated	activate	VERB
dti-1336	405	2	protein	protein	NOUN
dti-1336	405	3	c	c	NOUN
dti-1336	405	4	resistance	resistance	NOUN
dti-1336	405	5	in	in	ADP
dti-1336	405	6	the	the	DET
dti-1336	405	7	absence	absence	NOUN
dti-1336	405	8	of	of	ADP
dti-1336	405	9	factor	factor	NOUN
dti-1336	405	10	v	v	PROPN
dti-1336	405	11	leiden	leiden	PROPN
dti-1336	405	12	mutation	mutation	NOUN
dti-1336	405	13	is	be	AUX
dti-1336	405	14	a	a	DET
dti-1336	405	15	common	common	ADJ
dti-1336	405	16	fi	fi	NOUN
dti-1336	405	17	nding	nde	VERB
dti-1336	405	18	in	in	ADP
dti-1336	405	19	multiple	multiple	ADJ
dti-1336	405	20	myeloma	myeloma	NOUN
dti-1336	405	21	and	and	CCONJ
dti-1336	405	22	is	be	AUX
dti-1336	405	23	associated	associate	VERB
dti-1336	405	24	with	with	ADP
dti-1336	405	25	an	an	DET
dti-1336	405	26	increased	increase	VERB
dti-1336	405	27	risk	risk	NOUN
dti-1336	405	28	of	of	ADP
dti-1336	405	29	thrombotic	thrombotic	ADJ
dti-1336	405	30	complications	complication	NOUN
dti-1336	405	31	.	.	PUNCT
dti-1336	406	1	blood	blood	NOUN
dti-1336	406	2	coagul	coagul	NOUN
dti-1336	406	3	.	.	PUNCT
dti-1336	407	1	fibrinolysis	fibrinolysis	NOUN
dti-1336	407	2	,	,	PUNCT
dti-1336	407	3	13(3):187–92	13(3):187–92	NUM
dti-1336	407	4	.	.	PUNCT
dti-1336	408	1	[	[	X
dti-1336	408	2	70	70	NUM
dti-1336	408	3	]	]	X
dti-1336	408	4	miyakis	miyaki	NOUN
dti-1336	408	5	,	,	PUNCT
dti-1336	408	6	s.	s.	PROPN
dti-1336	408	7	,	,	PUNCT
dti-1336	408	8	lockshin	lockshin	PROPN
dti-1336	408	9	,	,	PUNCT
dti-1336	408	10	m.d	m.d	PROPN
dti-1336	408	11	.	.	PROPN
dti-1336	408	12	,	,	PUNCT
dti-1336	408	13	atsumi	atsumi	PROPN
dti-1336	408	14	,	,	PUNCT
dti-1336	408	15	t.	t.	PROPN
dti-1336	408	16	,	,	PUNCT
dti-1336	408	17	branch	branch	NOUN
dti-1336	408	18	,	,	PUNCT
dti-1336	408	19	d.w	d.w	PROPN
dti-1336	408	20	.	.	PROPN
dti-1336	408	21	,	,	PUNCT
dti-1336	408	22	brey	brey	PROPN
dti-1336	408	23	,	,	PUNCT
dti-1336	408	24	r.l	r.l	PROPN
dti-1336	408	25	.	.	PROPN
dti-1336	408	26	,	,	PUNCT
dti-1336	408	27	cervera	cervera	NOUN
dti-1336	408	28	,	,	PUNCT
dti-1336	408	29	r.	r.	PROPN
dti-1336	408	30	,	,	PUNCT
dti-1336	408	31	derksen	derksen	PROPN
dti-1336	408	32	,	,	PUNCT
dti-1336	408	33	r.h.w.m	r.h.w.m	PROPN
dti-1336	408	34	.	.	PROPN
dti-1336	408	35	,	,	PUNCT
dti-1336	408	36	de	de	X
dti-1336	408	37	groot	groot	PROPN
dti-1336	408	38	,	,	PUNCT
dti-1336	408	39	p.g	p.g	PROPN
dti-1336	408	40	.	.	PROPN
dti-1336	408	41	,	,	PUNCT
dti-1336	408	42	koike	koike	NOUN
dti-1336	408	43	,	,	PUNCT
dti-1336	408	44	t.	t.	PROPN
dti-1336	408	45	,	,	PUNCT
dti-1336	408	46	meroni	meroni	PROPN
dti-1336	408	47	,	,	PUNCT
dti-1336	408	48	p.l	p.l	PROPN
dti-1336	408	49	.	.	PROPN
dti-1336	408	50	,	,	PUNCT
dti-1336	408	51	reber	reber	PROPN
dti-1336	408	52	,	,	PUNCT
dti-1336	408	53	g.	g.	PROPN
dti-1336	408	54	,	,	PUNCT
dti-1336	408	55	shoenfeld	shoenfeld	VERB
dti-1336	408	56	,	,	PUNCT
dti-1336	408	57	y.	y.	NOUN
dti-1336	408	58	,	,	PUNCT
dti-1336	408	59	tincani	tincani	PROPN
dti-1336	408	60	,	,	PUNCT
dti-1336	408	61	a.	a.	NOUN
dti-1336	408	62	,	,	PUNCT
dti-1336	408	63	vlachoyiannopoulos	vlachoyiannopoulo	NOUN
dti-1336	408	64	,	,	PUNCT
dti-1336	408	65	p.g	p.g	PROPN
dti-1336	408	66	.	.	PROPN
dti-1336	408	67	and	and	CCONJ
dti-1336	408	68	krilis	krilis	PROPN
dti-1336	408	69	,	,	PUNCT
dti-1336	408	70	s.a	s.a	PROPN
dti-1336	408	71	.	.	PROPN
dti-1336	408	72	2006	2006	NUM
dti-1336	408	73	.	.	PUNCT
dti-1336	409	1	international	international	ADJ
dti-1336	409	2	consensus	consensus	NOUN
dti-1336	409	3	statement	statement	NOUN
dti-1336	409	4	on	on	ADP
dti-1336	409	5	an	an	DET
dti-1336	409	6	update	update	NOUN
dti-1336	409	7	of	of	ADP
dti-1336	409	8	the	the	DET
dti-1336	409	9	classification	classification	NOUN
dti-1336	409	10	criteria	criterion	NOUN
dti-1336	409	11	for	for	ADP
dti-1336	409	12	definite	definite	ADJ
dti-1336	409	13	antiphospholipid	antiphospholipid	NOUN
dti-1336	409	14	syndrome	syndrome	NOUN
dti-1336	409	15	(	(	PUNCT
dti-1336	409	16	aps	aps	PROPN
dti-1336	409	17	)	)	PUNCT
dti-1336	409	18	.	.	PUNCT
dti-1336	410	1	j.	j.	PROPN
dti-1336	410	2	thromb	thromb	PROPN
dti-1336	410	3	.	.	PUNCT
dti-1336	411	1	haem	haem	PROPN
dti-1336	411	2	.	.	PUNCT
dti-1336	411	3	,	,	PUNCT
dti-1336	412	1	4:295–306	4:295–306	NOUN
dti-1336	412	2	.	.	PUNCT
dti-1336	413	1	[	[	X
dti-1336	413	2	71	71	NUM
dti-1336	413	3	]	]	SYM
dti-1336	413	4	middeldorp	middeldorp	PROPN
dti-1336	413	5	,	,	PUNCT
dti-1336	413	6	s.	s.	PROPN
dti-1336	413	7	,	,	PUNCT
dti-1336	413	8	meinardi	meinardi	NOUN
dti-1336	413	9	,	,	PUNCT
dti-1336	413	10	j.r	j.r	PROPN
dti-1336	413	11	.	.	PROPN
dti-1336	413	12	,	,	PUNCT
dti-1336	413	13	koopman	koopman	PROPN
dti-1336	413	14	,	,	PUNCT
dti-1336	413	15	m.m	m.m	PROPN
dti-1336	413	16	.	.	PROPN
dti-1336	413	17	,	,	PUNCT
dti-1336	413	18	van	van	PROPN
dti-1336	413	19	pampus	pampus	PROPN
dti-1336	413	20	,	,	PUNCT
dti-1336	413	21	e.c	e.c	PROPN
dti-1336	413	22	.	.	PROPN
dti-1336	413	23	,	,	PUNCT
dti-1336	413	24	hamulyak	hamulyak	NOUN
dti-1336	413	25	,	,	PUNCT
dti-1336	413	26	k.	k.	PROPN
dti-1336	413	27	,	,	PUNCT
dti-1336	413	28	van	van	PROPN
dti-1336	413	29	der	der	PROPN
dti-1336	413	30	meer	meer	PROPN
dti-1336	413	31	,	,	PUNCT
dti-1336	413	32	j.	j.	PROPN
dti-1336	413	33	et	et	PROPN
dti-1336	413	34	al	al	PROPN
dti-1336	413	35	.	.	PROPN
dti-1336	413	36	2001	2001	NUM
dti-1336	413	37	.	.	PUNCT
dti-1336	414	1	a	a	DET
dti-1336	414	2	prospective	prospective	ADJ
dti-1336	414	3	study	study	NOUN
dti-1336	414	4	of	of	ADP
dti-1336	414	5	asymptomatic	asymptomatic	ADJ
dti-1336	414	6	carriers	carrier	NOUN
dti-1336	414	7	of	of	ADP
dti-1336	414	8	the	the	DET
dti-1336	414	9	faxtor	faxtor	PROPN
dti-1336	414	10	v	v	PROPN
dti-1336	414	11	leiden	leiden	PROPN
dti-1336	414	12	mutation	mutation	NOUN
dti-1336	414	13	to	to	PART
dti-1336	414	14	determine	determine	VERB
dti-1336	414	15	the	the	DET
dti-1336	414	16	incidence	incidence	NOUN
dti-1336	414	17	of	of	ADP
dti-1336	414	18	venous	venous	ADJ
dti-1336	414	19	thromboembolism	thromboembolism	NOUN
dti-1336	414	20	.	.	PUNCT
dti-1336	415	1	ann	ann	PROPN
dti-1336	415	2	.	.	PUNCT
dti-1336	415	3	intern	intern	PROPN
dti-1336	415	4	.	.	PUNCT
dti-1336	416	1	med	med	PROPN
dti-1336	416	2	.	.	PROPN
dti-1336	416	3	,	,	PUNCT
dti-1336	416	4	135:322–7	135:322–7	NUM
dti-1336	416	5	.	.	PUNCT
dti-1336	417	1	[	[	X
dti-1336	417	2	72	72	NUM
dti-1336	417	3	]	]	PUNCT
dti-1336	417	4	lensing	lensing	NOUN
dti-1336	417	5	,	,	PUNCT
dti-1336	417	6	a.w	a.w	PROPN
dti-1336	417	7	.	.	PROPN
dti-1336	417	8	and	and	CCONJ
dti-1336	417	9	prins	prins	PROPN
dti-1336	417	10	,	,	PUNCT
dti-1336	417	11	m.h	m.h	PROPN
dti-1336	417	12	.	.	PROPN
dti-1336	417	13	1999	1999	NUM
dti-1336	417	14	.	.	PUNCT
dti-1336	418	1	recurrent	recurrent	ADJ
dti-1336	418	2	deep	deep	ADJ
dti-1336	418	3	vein	vein	ADJ
dti-1336	418	4	thrombosis	thrombosis	NOUN
dti-1336	418	5	and	and	CCONJ
dti-1336	418	6	two	two	NUM
dti-1336	418	7	coagulation	coagulation	NOUN
dti-1336	418	8	factor	factor	NOUN
dti-1336	418	9	gene	gene	NOUN
dti-1336	418	10	mutations	mutation	NOUN
dti-1336	418	11	:	:	PUNCT
dti-1336	418	12	quo	quo	NOUN
dti-1336	418	13	vadis	vadis	PROPN
dti-1336	418	14	?	?	PUNCT
dti-1336	419	1	thromb	thromb	PROPN
dti-1336	419	2	.	.	PUNCT
dti-1336	420	1	haemost	haemost	PROPN
dti-1336	420	2	.	.	PUNCT
dti-1336	420	3	,	,	PUNCT
dti-1336	420	4	82:1564–6	82:1564–6	X
dti-1336	420	5	.	.	PUNCT
dti-1336	421	1	[	[	X
dti-1336	421	2	73	73	NUM
dti-1336	421	3	]	]	X
dti-1336	421	4	de	de	X
dti-1336	421	5	stefano	stefano	PROPN
dti-1336	421	6	,	,	PUNCT
dti-1336	421	7	v.	v.	PROPN
dti-1336	421	8	,	,	PUNCT
dti-1336	421	9	martinelli	martinelli	PROPN
dti-1336	421	10	,	,	PUNCT
dti-1336	421	11	i.	i.	PROPN
dti-1336	421	12	,	,	PUNCT
dti-1336	421	13	mannucci	mannucci	PROPN
dti-1336	421	14	,	,	PUNCT
dti-1336	421	15	p.m.	p.m.	NOUN
dti-1336	421	16	,	,	PUNCT
dti-1336	421	17	paciaroni	paciaroni	NOUN
dti-1336	421	18	,	,	PUNCT
dti-1336	421	19	k.	k.	PROPN
dti-1336	421	20	,	,	PUNCT
dti-1336	421	21	chiusolo	chiusolo	PROPN
dti-1336	421	22	,	,	PUNCT
dti-1336	421	23	p.	p.	NOUN
dti-1336	421	24	,	,	PUNCT
dti-1336	421	25	casorelli	casorelli	PROPN
dti-1336	421	26	,	,	PUNCT
dti-1336	421	27	i.	i.	PROPN
dti-1336	421	28	et	et	PROPN
dti-1336	421	29	al	al	PROPN
dti-1336	421	30	.	.	PROPN
dti-1336	421	31	1999	1999	NUM
dti-1336	421	32	.	.	PUNCT
dti-1336	422	1	the	the	DET
dti-1336	422	2	risk	risk	NOUN
dti-1336	422	3	of	of	ADP
dti-1336	422	4	recurrent	recurrent	ADJ
dti-1336	422	5	deep	deep	ADJ
dti-1336	422	6	venous	venous	ADJ
dti-1336	422	7	thromobisis	thromobisis	NOUN
dti-1336	422	8	among	among	ADP
dti-1336	422	9	heterozygous	heterozygous	ADJ
dti-1336	422	10	carriers	carrier	NOUN
dti-1336	422	11	of	of	ADP
dti-1336	422	12	both	both	DET
dti-1336	422	13	factor	factor	NOUN
dti-1336	422	14	v	v	NOUN
dti-1336	422	15	leiden	leiden	PROPN
dti-1336	422	16	and	and	CCONJ
dti-1336	422	17	the	the	DET
dti-1336	422	18	g20210a	g20210a	ADJ
dti-1336	422	19	prothrombin	prothrombin	NOUN
dti-1336	422	20	mutation	mutation	NOUN
dti-1336	422	21	.	.	PUNCT
dti-1336	423	1	n.	n.	PROPN
dti-1336	423	2	engl	engl	PROPN
dti-1336	423	3	.	.	PUNCT
dti-1336	424	1	j.	j.	PROPN
dti-1336	424	2	med	med	PROPN
dti-1336	424	3	.	.	PROPN
dti-1336	424	4	,	,	PUNCT
dti-1336	424	5	341:801–6	341:801–6	NUM
dti-1336	424	6	.	.	PUNCT
dti-1336	425	1	[	[	X
dti-1336	425	2	74	74	NUM
dti-1336	425	3	]	]	X
dti-1336	425	4	lee	lee	PROPN
dti-1336	425	5	,	,	PUNCT
dti-1336	425	6	ayy	ayy	PROPN
dti-1336	425	7	.	.	PROPN
dti-1336	425	8	,	,	PUNCT
dti-1336	425	9	rickles	rickles	PROPN
dti-1336	425	10	,	,	PUNCT
dti-1336	425	11	f.r	f.r	PROPN
dti-1336	425	12	.	.	PROPN
dti-1336	425	13	,	,	PUNCT
dti-1336	425	14	julian	julian	PROPN
dti-1336	425	15	,	,	PUNCT
dti-1336	425	16	j.a	j.a	PROPN
dti-1336	425	17	.	.	PROPN
dti-1336	425	18	et	et	PROPN
dti-1336	425	19	al	al	PROPN
dti-1336	425	20	.	.	PROPN
dti-1336	425	21	2005	2005	NUM
dti-1336	425	22	.	.	PUNCT
dti-1336	426	1	randomized	randomize	VERB
dti-1336	426	2	comparison	comparison	NOUN
dti-1336	426	3	of	of	ADP
dti-1336	426	4	low	low	ADJ
dti-1336	426	5	molecular	molecular	ADJ
dti-1336	426	6	weight	weight	NOUN
dti-1336	426	7	heparin	heparin	NOUN
dti-1336	426	8	and	and	CCONJ
dti-1336	426	9	coumarin	coumarin	NOUN
dti-1336	426	10	derivatives	derivative	NOUN
dti-1336	426	11	on	on	ADP
dti-1336	426	12	the	the	DET
dti-1336	426	13	survival	survival	NOUN
dti-1336	426	14	of	of	ADP
dti-1336	426	15	patients	patient	NOUN
dti-1336	426	16	with	with	ADP
dti-1336	426	17	cancer	cancer	NOUN
dti-1336	426	18	and	and	CCONJ
dti-1336	426	19	venous	venous	ADJ
dti-1336	426	20	thromboembolism	thromboembolism	NOUN
dti-1336	426	21	.	.	PUNCT
dti-1336	427	1	j.	j.	PROPN
dti-1336	427	2	clin	clin	PROPN
dti-1336	427	3	.	.	PUNCT
dti-1336	428	1	oncol	oncol	PROPN
dti-1336	428	2	.	.	PUNCT
dti-1336	428	3	,	,	PUNCT
dti-1336	429	1	23:2123–9	23:2123–9	NUM
dti-1336	429	2	.	.	PUNCT
dti-1336	430	1	[	[	X
dti-1336	430	2	75	75	NUM
dti-1336	430	3	]	]	X
dti-1336	430	4	klerk	klerk	NOUN
dti-1336	430	5	,	,	PUNCT
dti-1336	430	6	c.p.w	c.p.w	NOUN
dti-1336	430	7	.	.	PROPN
dti-1336	430	8	,	,	PUNCT
dti-1336	430	9	smorenburg	smorenburg	PROPN
dti-1336	430	10	,	,	PUNCT
dti-1336	430	11	s.m	s.m	PROPN
dti-1336	430	12	.	.	PROPN
dti-1336	430	13	,	,	PUNCT
dti-1336	430	14	otten	otten	PROPN
dti-1336	430	15	,	,	PUNCT
dti-1336	430	16	h.m	h.m	PROPN
dti-1336	430	17	.	.	PROPN
dti-1336	430	18	et	et	PROPN
dti-1336	430	19	al	al	PROPN
dti-1336	430	20	.	.	PROPN
dti-1336	430	21	2005	2005	NUM
dti-1336	430	22	.	.	PUNCT
dti-1336	431	1	the	the	DET
dti-1336	431	2	effect	effect	NOUN
dti-1336	431	3	of	of	ADP
dti-1336	431	4	low	low	ADJ
dti-1336	431	5	molecular	molecular	ADJ
dti-1336	431	6	weight	weight	NOUN
dti-1336	431	7	heparin	heparin	NOUN
dti-1336	431	8	on	on	ADP
dti-1336	431	9	survival	survival	NOUN
dti-1336	431	10	in	in	ADP
dti-1336	431	11	patients	patient	NOUN
dti-1336	431	12	with	with	ADP
dti-1336	431	13	advanced	advanced	ADJ
dti-1336	431	14	malignancy	malignancy	NOUN
dti-1336	431	15	.	.	PUNCT
dti-1336	432	1	j.	j.	PROPN
dti-1336	432	2	clin	clin	PROPN
dti-1336	432	3	.	.	PUNCT
dti-1336	433	1	oncol	oncol	PROPN
dti-1336	433	2	.	.	PUNCT
dti-1336	433	3	,	,	PUNCT
dti-1336	433	4	23:2130–5	23:2130–5	NUM
dti-1336	433	5	.	.	PUNCT
dti-1336	434	1	[	[	X
dti-1336	434	2	76	76	NUM
dti-1336	434	3	]	]	X
dti-1336	434	4	geerts	geert	NOUN
dti-1336	434	5	,	,	PUNCT
dti-1336	434	6	wh	wh	PROPN
dti-1336	434	7	.	.	PROPN
dti-1336	434	8	,	,	PUNCT
dti-1336	434	9	pineo	pineo	PROPN
dti-1336	434	10	,	,	PUNCT
dti-1336	434	11	g.f	g.f	PROPN
dti-1336	434	12	.	.	PROPN
dti-1336	434	13	,	,	PUNCT
dti-1336	434	14	heit	heit	PROPN
dti-1336	434	15	,	,	PUNCT
dti-1336	434	16	j.a	j.a	PROPN
dti-1336	434	17	.	.	PROPN
dti-1336	434	18	et	et	PROPN
dti-1336	434	19	al	al	PROPN
dti-1336	434	20	.	.	PROPN
dti-1336	434	21	2004	2004	NUM
dti-1336	434	22	.	.	PUNCT
dti-1336	435	1	prevention	prevention	NOUN
dti-1336	435	2	of	of	ADP
dti-1336	435	3	venous	venous	ADJ
dti-1336	435	4	thromboembolism	thromboembolism	NOUN
dti-1336	435	5	.	.	PUNCT
dti-1336	436	1	the	the	DET
dti-1336	436	2	seventh	seventh	ADJ
dti-1336	436	3	accp	accp	PROPN
dti-1336	436	4	consensus	consensus	NOUN
dti-1336	436	5	conference	conference	NOUN
dti-1336	436	6	on	on	ADP
dti-1336	436	7	antithrombotic	antithrombotic	ADJ
dti-1336	436	8	and	and	CCONJ
dti-1336	436	9	thrombolytic	thrombolytic	ADJ
dti-1336	436	10	therapy	therapy	NOUN
dti-1336	436	11	.	.	PUNCT
dti-1336	437	1	chest	chest	NOUN
dti-1336	437	2	,	,	PUNCT
dti-1336	437	3	136:338s–400s	136:338s–400s	NUM
dti-1336	437	4	.	.	PUNCT
dti-1336	438	1	[	[	X
dti-1336	438	2	77	77	NUM
dti-1336	438	3	]	]	X
dti-1336	438	4	büller	büller	PROPN
dti-1336	438	5	,	,	PUNCT
dti-1336	438	6	h.r	h.r	PROPN
dti-1336	438	7	.	.	PROPN
dti-1336	438	8	,	,	PUNCT
dti-1336	438	9	agnelli	agnelli	PROPN
dti-1336	438	10	,	,	PUNCT
dti-1336	438	11	g.	g.	PROPN
dti-1336	438	12	,	,	PUNCT
dti-1336	438	13	hull	hull	NOUN
dti-1336	438	14	,	,	PUNCT
dti-1336	438	15	r.d	r.d	PROPN
dti-1336	438	16	.	.	PROPN
dti-1336	438	17	et	et	PROPN
dti-1336	438	18	al	al	PROPN
dti-1336	438	19	.	.	PROPN
dti-1336	438	20	2004	2004	NUM
dti-1336	438	21	.	.	PUNCT
dti-1336	439	1	antithrombotic	antithrombotic	ADJ
dti-1336	439	2	therapy	therapy	NOUN
dti-1336	439	3	of	of	ADP
dti-1336	439	4	r	r	NOUN
dti-1336	439	5	venous	venous	ADJ
dti-1336	439	6	thromboembolic	thromboembolic	NOUN
dti-1336	439	7	disease	disease	NOUN
dti-1336	439	8	.	.	PUNCT
dti-1336	440	1	the	the	DET
dti-1336	440	2	seventh	seventh	ADJ
dti-1336	440	3	accp	accp	NOUN
dti-1336	440	4	consensus	consensus	NOUN
dti-1336	440	5	confernce	confernce	NOUN
dti-1336	440	6	on	on	ADP
dti-1336	440	7	antithrombotic	antithrombotic	ADJ
dti-1336	440	8	and	and	CCONJ
dti-1336	440	9	thrombolytic	thrombolytic	ADJ
dti-1336	440	10	therapy	therapy	NOUN
dti-1336	440	11	.	.	PUNCT
dti-1336	441	1	chest	chest	NOUN
dti-1336	441	2	,	,	PUNCT
dti-1336	441	3	126:401s–28s	126:401s–28s	X
dti-1336	441	4	.	.	PUNCT
dti-1336	442	1	[	[	X
dti-1336	442	2	78	78	NUM
dti-1336	442	3	]	]	PUNCT
dti-1336	442	4	zangari	zangari	PROPN
dti-1336	442	5	,	,	PUNCT
dti-1336	442	6	m.	m.	NOUN
dti-1336	442	7	,	,	PUNCT
dti-1336	442	8	barlogie	barlogie	NOUN
dti-1336	442	9	,	,	PUNCT
dti-1336	442	10	b.	b.	PROPN
dti-1336	442	11	,	,	PUNCT
dti-1336	442	12	anaissie	anaissie	PROPN
dti-1336	442	13	,	,	PUNCT
dti-1336	442	14	e.	e.	PROPN
dti-1336	442	15	,	,	PUNCT
dti-1336	442	16	saghafi	saghafi	VERB
dti-1336	442	17	far	far	ADV
dti-1336	442	18	,	,	PUNCT
dti-1336	442	19	f.	f.	PROPN
dti-1336	442	20	,	,	PUNCT
dti-1336	442	21	eddlemon	eddlemon	NOUN
dti-1336	442	22	,	,	PUNCT
dti-1336	442	23	p.	p.	PROPN
dti-1336	442	24	,	,	PUNCT
dti-1336	442	25	jacobson	jacobson	PROPN
dti-1336	442	26	,	,	PUNCT
dti-1336	442	27	j.	j.	PROPN
dti-1336	442	28	et	et	PROPN
dti-1336	442	29	al	al	PROPN
dti-1336	442	30	.	.	PROPN
dti-1336	442	31	2004	2004	NUM
dti-1336	442	32	.	.	PUNCT
dti-1336	443	1	deep	deep	ADJ
dti-1336	443	2	vein	vein	ADJ
dti-1336	443	3	thrombosis	thrombosis	NOUN
dti-1336	443	4	in	in	ADP
dti-1336	443	5	patients	patient	NOUN
dti-1336	443	6	treated	treat	VERB
dti-1336	443	7	with	with	ADP
dti-1336	443	8	thalidomide	thalidomide	NOUN
dti-1336	443	9	and	and	CCONJ
dti-1336	443	10	chemotherapy	chemotherapy	NOUN
dti-1336	443	11	:	:	PUNCT
dti-1336	443	12	effects	effect	NOUN
dti-1336	443	13	of	of	ADP
dti-1336	443	14	prophylactic	prophylactic	ADJ
dti-1336	443	15	and	and	CCONJ
dti-1336	443	16	therapeutic	therapeutic	ADJ
dti-1336	443	17	anticoagulation	anticoagulation	NOUN
dti-1336	443	18	.	.	PUNCT
dti-1336	444	1	br	br	PROPN
dti-1336	444	2	.	.	PUNCT
dti-1336	445	1	j.	j.	PROPN
dti-1336	445	2	haematol	haematol	PROPN
dti-1336	445	3	.	.	PUNCT
dti-1336	445	4	,	,	PUNCT
dti-1336	445	5	126:715–21	126:715–21	NUM
dti-1336	445	6	.	.	PUNCT
dti-1336	446	1	[	[	X
dti-1336	446	2	79	79	NUM
dti-1336	446	3	]	]	PUNCT
dti-1336	446	4	heijboer	heijboer	NOUN
dti-1336	446	5	,	,	PUNCT
dti-1336	446	6	h.	h.	PROPN
dti-1336	446	7	,	,	PUNCT
dti-1336	446	8	brandjes	brandjes	PROPN
dti-1336	446	9	,	,	PUNCT
dti-1336	446	10	d.p.m	d.p.m	PROPN
dti-1336	446	11	.	.	PROPN
dti-1336	446	12	,	,	PUNCT
dti-1336	446	13	b.üller	b.üller	PROPN
dti-1336	446	14	,	,	PUNCT
dti-1336	446	15	h.r	h.r	PROPN
dti-1336	446	16	.	.	PROPN
dti-1336	446	17	et	et	PROPN
dti-1336	446	18	al	al	PROPN
dti-1336	446	19	.	.	PROPN
dti-1336	446	20	1990	1990	NUM
dti-1336	446	21	.	.	PUNCT
dti-1336	447	1	defi	defi	PROPN
dti-1336	447	2	ciencies	ciencie	NOUN
dti-1336	447	3	of	of	ADP
dti-1336	447	4	coagulation	coagulation	NOUN
dti-1336	447	5	-	-	PUNCT
dti-1336	447	6	inhibiting	inhibit	VERB
dti-1336	447	7	and	and	CCONJ
dti-1336	447	8	fi	fi	NOUN
dti-1336	447	9	brinolytic	brinolytic	ADJ
dti-1336	447	10	proteins	protein	NOUN
dti-1336	447	11	in	in	ADP
dti-1336	447	12	outpatients	outpatient	NOUN
dti-1336	447	13	with	with	ADP
dti-1336	447	14	deep	deep	ADJ
dti-1336	447	15	venous	venous	ADJ
dti-1336	447	16	thrombosis	thrombosis	NOUN
dti-1336	447	17	.	.	PUNCT
dti-1336	448	1	n.	n.	PROPN
dti-1336	448	2	engl	engl	PROPN
dti-1336	448	3	.	.	PUNCT
dti-1336	449	1	j.	j.	PROPN
dti-1336	449	2	md	md	PROPN
dti-1336	449	3	.	.	PROPN
dti-1336	449	4	,	,	PUNCT
dti-1336	449	5	323:1512	323:1512	NUM
dti-1336	449	6	.	.	PUNCT
dti-1336	450	1	[	[	X
dti-1336	450	2	80	80	NUM
dti-1336	450	3	]	]	PUNCT
dti-1336	450	4	d’angelo	d’angelo	PROPN
dti-1336	450	5	,	,	PUNCT
dti-1336	450	6	a.	a.	NOUN
dti-1336	450	7	and	and	CCONJ
dti-1336	450	8	selhub	selhub	PROPN
dti-1336	450	9	,	,	PUNCT
dti-1336	450	10	j.	j.	PROPN
dti-1336	450	11	1997	1997	NUM
dti-1336	450	12	.	.	PUNCT
dti-1336	451	1	homocysteine	homocysteine	NOUN
dti-1336	451	2	and	and	CCONJ
dti-1336	451	3	thrombotic	thrombotic	ADJ
dti-1336	451	4	disease	disease	NOUN
dti-1336	451	5	.	.	PUNCT
dti-1336	452	1	blood	blood	NOUN
dti-1336	452	2	,	,	PUNCT
dti-1336	452	3	90:1	90:1	PROPN
dti-1336	452	4	.	.	PUNCT
dti-1336	453	1	[	[	X
dti-1336	453	2	81	81	NUM
dti-1336	453	3	]	]	PUNCT
dti-1336	453	4	pabinger	pabinger	NOUN
dti-1336	453	5	,	,	PUNCT
dti-1336	453	6	i.	i.	PROPN
dti-1336	453	7	,	,	PUNCT
dti-1336	453	8	brucker	brucker	NOUN
dti-1336	453	9	,	,	PUNCT
dti-1336	453	10	s.	s.	PROPN
dti-1336	453	11	,	,	PUNCT
dti-1336	453	12	kyrle	kyrle	PROPN
dti-1336	453	13	,	,	PUNCT
dti-1336	453	14	p.a	p.a	PROPN
dti-1336	453	15	.	.	PROPN
dti-1336	453	16	,	,	PUNCT
dti-1336	453	17	schneider	schneider	PROPN
dti-1336	453	18	,	,	PUNCT
dti-1336	453	19	b.	b.	PROPN
dti-1336	453	20	,	,	PUNCT
dti-1336	453	21	korninger	korninger	PROPN
dti-1336	453	22	,	,	PUNCT
dti-1336	453	23	h.c	h.c	PROPN
dti-1336	453	24	.	.	PROPN
dti-1336	453	25	,	,	PUNCT
dti-1336	453	26	niessner	niessner	PROPN
dti-1336	453	27	,	,	PUNCT
dti-1336	453	28	h.	h.	PROPN
dti-1336	453	29	and	and	CCONJ
dti-1336	453	30	lechner	lechner	PROPN
dti-1336	453	31	,	,	PUNCT
dti-1336	453	32	k.	k.	PROPN
dti-1336	453	33	1992	1992	NUM
dti-1336	453	34	.	.	PUNCT
dti-1336	454	1	hereditary	hereditary	ADJ
dti-1336	454	2	defi	defi	NOUN
dti-1336	454	3	ciency	ciency	NOUN
dti-1336	454	4	of	of	ADP
dti-1336	454	5	antithrombin	antithrombin	PROPN
dti-1336	454	6	iii	iii	PROPN
dti-1336	454	7	,	,	PUNCT
dti-1336	454	8	protein	protein	NOUN
dti-1336	454	9	c	c	NOUN
dti-1336	454	10	and	and	CCONJ
dti-1336	454	11	protein	protein	NOUN
dti-1336	454	12	s	s	PART
dti-1336	454	13	:	:	PUNCT
dti-1336	454	14	prevalence	prevalence	NOUN
dti-1336	454	15	in	in	ADP
dti-1336	454	16	patients	patient	NOUN
dti-1336	454	17	with	with	ADP
dti-1336	454	18	a	a	DET
dti-1336	454	19	history	history	NOUN
dti-1336	454	20	of	of	ADP
dti-1336	454	21	venous	venous	ADJ
dti-1336	454	22	thrombosis	thrombosis	NOUN
dti-1336	454	23	and	and	CCONJ
dti-1336	454	24	criteria	criterion	NOUN
dti-1336	454	25	for	for	ADP
dti-1336	454	26	rational	rational	ADJ
dti-1336	454	27	patient	patient	ADJ
dti-1336	454	28	screening	screening	NOUN
dti-1336	454	29	.	.	PUNCT
dti-1336	455	1	blood	blood	NOUN
dti-1336	455	2	coagul	coagul	NOUN
dti-1336	455	3	.	.	PUNCT
dti-1336	456	1	fibrinolysis	fibrinolysis	NOUN
dti-1336	456	2	,	,	PUNCT
dti-1336	456	3	3:547–53	3:547–53	NOUN
dti-1336	456	4	.	.	PUNCT
dti-1336	457	1	[	[	X
dti-1336	457	2	82	82	NUM
dti-1336	457	3	]	]	X
dti-1336	457	4	halbmeyer	halbmeyer	PROPN
dti-1336	457	5	,	,	PUNCT
dti-1336	457	6	w.m	w.m	PROPN
dti-1336	457	7	.	.	PROPN
dti-1336	457	8	,	,	PUNCT
dti-1336	457	9	haushofer	haushofer	PROPN
dti-1336	457	10	,	,	PUNCT
dti-1336	457	11	a.	a.	NOUN
dti-1336	457	12	,	,	PUNCT
dti-1336	457	13	schon	schon	PROPN
dti-1336	457	14	,	,	PUNCT
dti-1336	457	15	r.	r.	PROPN
dti-1336	457	16	,	,	PUNCT
dti-1336	457	17	mannhalter	mannhalter	PROPN
dti-1336	457	18	,	,	PUNCT
dti-1336	457	19	c.	c.	PROPN
dti-1336	457	20	,	,	PUNCT
dti-1336	457	21	strohmer	strohmer	PROPN
dti-1336	457	22	,	,	PUNCT
dti-1336	457	23	e.	e.	PROPN
dti-1336	457	24	,	,	PUNCT
dti-1336	457	25	baumgarten	baumgarten	VERB
dti-1336	457	26	,	,	PUNCT
dti-1336	457	27	k.	k.	PROPN
dti-1336	457	28	and	and	CCONJ
dti-1336	457	29	fischer	fischer	PROPN
dti-1336	457	30	,	,	PUNCT
dti-1336	457	31	m.	m.	NOUN
dti-1336	457	32	1994	1994	NUM
dti-1336	457	33	.	.	PUNCT
dti-1336	458	1	the	the	DET
dti-1336	458	2	prevalence	prevalence	NOUN
dti-1336	458	3	of	of	ADP
dti-1336	458	4	moderate	moderate	ADJ
dti-1336	458	5	and	and	CCONJ
dti-1336	458	6	severe	severe	ADJ
dti-1336	458	7	fxii	fxii	NOUN
dti-1336	458	8	(	(	PUNCT
dti-1336	458	9	hageman	hageman	NOUN
dti-1336	458	10	factor	factor	NOUN
dti-1336	458	11	)	)	PUNCT
dti-1336	458	12	defi	defi	NOUN
dti-1336	458	13	ciency	ciency	NOUN
dti-1336	458	14	among	among	ADP
dti-1336	458	15	the	the	DET
dti-1336	458	16	normal	normal	ADJ
dti-1336	458	17	population	population	NOUN
dti-1336	458	18	:	:	PUNCT
dti-1336	458	19	evaluation	evaluation	NOUN
dti-1336	458	20	of	of	ADP
dti-1336	458	21	the	the	DET
dti-1336	458	22	incidence	incidence	NOUN
dti-1336	458	23	of	of	ADP
dti-1336	458	24	fxii	fxii	PROPN
dti-1336	458	25	defi	defi	PROPN
dti-1336	458	26	ciency	ciency	NOUN
dti-1336	458	27	among	among	ADP
dti-1336	458	28	300	300	NUM
dti-1336	458	29	healthy	healthy	ADJ
dti-1336	458	30	blood	blood	NOUN
dti-1336	458	31	donors	donor	NOUN
dti-1336	458	32	.	.	PUNCT
dti-1336	459	1	thromb	thromb	NOUN
dti-1336	459	2	.	.	PUNCT
dti-1336	460	1	haemost	haemost	PROPN
dti-1336	460	2	,	,	PUNCT
dti-1336	460	3	71:68–72	71:68–72	NUM
dti-1336	460	4	.	.	PUNCT
dti-1336	461	1	[	[	X
dti-1336	461	2	83	83	NUM
dti-1336	461	3	]	]	SYM
dti-1336	461	4	bockenstedt	bockenstedt	PROPN
dti-1336	461	5	,	,	PUNCT
dti-1336	461	6	p.l	p.l	PROPN
dti-1336	461	7	.	.	PROPN
dti-1336	461	8	2006	2006	NUM
dti-1336	461	9	.	.	PUNCT
dti-1336	462	1	management	management	NOUN
dti-1336	462	2	of	of	ADP
dti-1336	462	3	hereditary	hereditary	ADJ
dti-1336	462	4	hypercoagulable	hypercoagulable	ADJ
dti-1336	462	5	disorders	disorder	NOUN
dti-1336	462	6	.	.	PUNCT
dti-1336	463	1	hematology	hematology	NOUN
dti-1336	463	2	am	be	AUX
dti-1336	463	3	.	.	PUNCT
dti-1336	464	1	soc	soc	PROPN
dti-1336	464	2	.	.	PUNCT
dti-1336	465	1	hematol	hematol	NOUN
dti-1336	465	2	.	.	PUNCT
dti-1336	466	1	educ	educ	PROPN
dti-1336	466	2	.	.	PUNCT
dti-1336	467	1	program	program	PROPN
dti-1336	467	2	,	,	PUNCT
dti-1336	467	3	444–9	444–9	NOUN
dti-1336	467	4	.	.	PUNCT
dti-1336	468	1	<	<	X
dti-1336	468	2	<	<	X
dti-1336	468	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1336	468	4	false	false	ADJ
dti-1336	468	5	/allowtransparency	/allowtransparency	NOUN
dti-1336	468	6	false	false	ADJ
dti-1336	468	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1336	468	8	true	true	ADJ
dti-1336	468	9	/autorotatepages	/autorotatepage	NOUN
dti-1336	468	10	/none	/none	PUNCT
dti-1336	468	11	/binding	/binding	PUNCT
dti-1336	468	12	/left	/left	ADJ
dti-1336	469	1	/calgrayprofile	/calgrayprofile	VERB
dti-1336	469	2	(	(	PUNCT
dti-1336	469	3	dot	dot	NOUN
dti-1336	469	4	gain	gain	NOUN
dti-1336	469	5	20	20	NUM
dti-1336	469	6	%	%	NOUN
dti-1336	469	7	)	)	PUNCT
dti-1336	469	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1336	470	1	(	(	PUNCT
dti-1336	470	2	srgb	srgb	PROPN
dti-1336	470	3	iec61966	iec61966	NOUN
dti-1336	470	4	-	-	PUNCT
dti-1336	470	5	2.1	2.1	NUM
dti-1336	470	6	)	)	PUNCT
dti-1336	470	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1336	471	1	(	(	PUNCT
dti-1336	471	2	u.s	u.s	PROPN
dti-1336	471	3	.	.	PROPN
dti-1336	471	4	web	web	NOUN
dti-1336	471	5	coated	coat	VERB
dti-1336	471	6	\050swop\051	\050swop\051	ADJ
dti-1336	471	7	v2	v2	NOUN
dti-1336	471	8	)	)	PUNCT
dti-1336	471	9	/srgbprofile	/srgbprofile	PUNCT
dti-1336	471	10	(	(	PUNCT
dti-1336	471	11	srgb	srgb	PROPN
dti-1336	471	12	iec61966	iec61966	NOUN
dti-1336	471	13	-	-	PUNCT
dti-1336	471	14	2.1	2.1	NUM
dti-1336	471	15	)	)	PUNCT
dti-1336	471	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1336	472	1	/error	/error	INTJ
dti-1336	472	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1336	473	1	1.4	1.4	NUM
dti-1336	473	2	/compressobjects	/compressobject	NOUN
dti-1336	473	3	/tags	/tag	VERB
dti-1336	473	4	/compresspages	/compresspage	NOUN
dti-1336	473	5	true	true	ADJ
dti-1336	473	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1336	473	7	true	true	ADJ
dti-1336	473	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1336	473	9	true	true	ADJ
dti-1336	473	10	/createjdffile	/createjdffile	ADJ
dti-1336	473	11	false	false	ADJ
dti-1336	473	12	/createjobticket	/createjobticket	NOUN
dti-1336	473	13	false	false	ADJ
dti-1336	473	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1336	473	15	/default	/default	PUNCT
dti-1336	473	16	/detectblends	/detectblend	NOUN
dti-1336	473	17	true	true	ADJ
dti-1336	473	18	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1336	473	19	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1336	473	20	/dothumbnails	/dothumbnail	VERB
dti-1336	473	21	false	false	ADJ
dti-1336	473	22	/embedallfonts	/embedallfont	NOUN
dti-1336	473	23	true	true	ADJ
dti-1336	473	24	/embedjoboptions	/embedjoboption	NOUN
dti-1336	473	25	true	true	ADJ
dti-1336	473	26	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1336	473	27	0	0	NUM
dti-1336	473	28	/emitdscwarnings	/emitdscwarning	NOUN
dti-1336	473	29	false	false	ADJ
dti-1336	473	30	/endpage	/endpage	NOUN
dti-1336	473	31	-1	-1	NOUN
dti-1336	473	32	/imagememory	/imagememory	NUM
dti-1336	474	1	1048576	1048576	NUM
dti-1336	474	2	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1336	474	3	false	false	ADJ
dti-1336	474	4	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1336	474	5	100	100	NUM
dti-1336	474	6	/optimize	/optimize	NOUN
dti-1336	474	7	true	true	ADJ
dti-1336	474	8	/opm	/opm	NOUN
dti-1336	474	9	1	1	NUM
dti-1336	474	10	/parsedsccomments	/parsedsccomment	NOUN
dti-1336	474	11	true	true	ADJ
dti-1336	474	12	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1336	474	13	true	true	ADJ
dti-1336	474	14	/preservecopypage	/preservecopypage	NOUN
dti-1336	474	15	true	true	ADJ
dti-1336	474	16	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1336	474	17	true	true	ADJ
dti-1336	474	18	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1336	474	19	false	false	ADJ
dti-1336	474	20	/preserveopicomments	/preserveopicomment	NOUN
dti-1336	474	21	false	false	ADJ
dti-1336	474	22	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1336	474	23	true	true	ADJ
dti-1336	474	24	/startpage	/startpage	NOUN
dti-1336	474	25	1	1	NUM
dti-1336	474	26	/subsetfonts	/subsetfont	NOUN
dti-1336	474	27	true	true	ADJ
dti-1336	474	28	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1336	474	29	/apply	/apply	PUNCT
dti-1336	474	30	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1336	475	1	/preserve	/preserve	NOUN
dti-1336	475	2	/useprologue	/useprologue	NOUN
dti-1336	475	3	false	false	ADJ
dti-1336	475	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1336	475	5	(	(	PUNCT
dti-1336	475	6	)	)	PUNCT
dti-1336	475	7	/alwaysembed	/alwaysembe	VERB
dti-1336	475	8	[	[	PUNCT
dti-1336	475	9	true	true	ADJ
dti-1336	475	10	]	]	PUNCT
dti-1336	475	11	/neverembed	/neverembed	PUNCT
dti-1336	476	1	[	[	PUNCT
dti-1336	476	2	true	true	ADJ
dti-1336	476	3	]	]	PUNCT
dti-1336	476	4	/antialiascolorimages	/antialiascolorimages	X
dti-1336	476	5	false	false	ADJ
dti-1336	476	6	/downsamplecolorimages	/downsamplecolorimage	NOUN
dti-1336	476	7	true	true	ADJ
dti-1336	476	8	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1336	476	9	/bicubic	/bicubic	NOUN
dti-1336	476	10	/colorimageresolution	/colorimageresolution	NOUN
dti-1336	476	11	300	300	NUM
dti-1336	476	12	/colorimagedepth	/colorimagedepth	PRON
dti-1336	477	1	-1	-1	INTJ
dti-1336	477	2	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	PUNCT
dti-1336	477	3	1.50000	1.50000	NUM
dti-1336	477	4	/encodecolorimages	/encodecolorimage	NOUN
dti-1336	477	5	true	true	ADJ
dti-1336	477	6	/colorimagefilter	/colorimagefilter	PUNCT
dti-1336	477	7	/dctencode	/dctencode	PUNCT
dti-1336	477	8	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1336	477	9	true	true	ADJ
dti-1336	477	10	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1336	477	11	/jpeg	/jpeg	PUNCT
dti-1336	477	12	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1336	478	1	<	<	X
dti-1336	478	2	<	<	X
dti-1336	478	3	/qfactor	/qfactor	NOUN
dti-1336	478	4	0.15	0.15	NUM
dti-1336	478	5	/hsamples	/hsample	NOUN
dti-1336	479	1	[	[	X
dti-1336	479	2	1	1	NUM
dti-1336	479	3	1	1	NUM
dti-1336	479	4	1	1	NUM
dti-1336	479	5	1	1	NUM
dti-1336	479	6	]	]	PUNCT
dti-1336	479	7	/vsamples	/vsample	NOUN
dti-1336	480	1	[	[	X
dti-1336	480	2	1	1	NUM
dti-1336	480	3	1	1	NUM
dti-1336	480	4	1	1	NUM
dti-1336	480	5	1	1	NUM
dti-1336	480	6	]	]	PUNCT
dti-1336	480	7	>	>	PUNCT
dti-1336	480	8	>	>	X
dti-1336	480	9	/colorimagedict	/colorimagedict	PUNCT
dti-1336	481	1	<	<	X
dti-1336	481	2	<	<	X
dti-1336	481	3	/qfactor	/qfactor	NOUN
dti-1336	481	4	0.15	0.15	NUM
dti-1336	481	5	/hsamples	/hsample	NOUN
dti-1336	482	1	[	[	X
dti-1336	482	2	1	1	NUM
dti-1336	482	3	1	1	NUM
dti-1336	482	4	1	1	NUM
dti-1336	482	5	1	1	NUM
dti-1336	482	6	]	]	PUNCT
dti-1336	482	7	/vsamples	/vsample	NOUN
dti-1336	483	1	[	[	X
dti-1336	483	2	1	1	NUM
dti-1336	483	3	1	1	NUM
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dti-1336	505	3	>	>	X
dti-1336	505	4	/esp	/esp	PUNCT
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dti-1336	506	4	/suo	/suo	PUNCT
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dti-1336	507	3	>	>	X
dti-1336	507	4	/ita	/ita	PUNCT
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dti-1336	508	3	>	>	X
dti-1336	508	4	/nor	/nor	X
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dti-1336	508	7	>	>	X
dti-1336	508	8	/sve	/sve	NOUN
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dti-1336	509	3	>	>	X
dti-1336	509	4	/enu	/enu	PROPN
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dti-1336	509	7	>	>	X
dti-1336	509	8	>	>	X
dti-1336	509	9	>	>	X
dti-1336	509	10	>	>	X
dti-1336	509	11	>	>	X
dti-1336	509	12	setdistillerparams	setdistillerparam	NOUN
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dti-1336	510	3	/hwresolution	/hwresolution	NOUN
dti-1336	511	1	[	[	X
dti-1336	511	2	2400	2400	NUM
dti-1336	511	3	2400	2400	NUM
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dti-1336	511	5	/pagesize	/pagesize	X
dti-1336	512	1	[	[	X
dti-1336	512	2	612.000	612.000	NUM
dti-1336	512	3	792.000	792.000	NUM
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dti-1336	512	5	>	>	PUNCT
dti-1336	512	6	>	>	X
dti-1336	512	7	setpagedevice	setpagedevice	PROPN