id	sid	tid	token	lemma	pos
dti-1337	1	1	begleiter	begleiter	PROPN
dti-1337	1	2	et	et	PROPN
dti-1337	1	3	al.indd	al.indd	PROPN
dti-1337	1	4	drug	drug	NOUN
dti-1337	1	5	target	target	NOUN
dti-1337	1	6	insights	insight	NOUN
dti-1337	1	7	2009:4	2009:4	NUM
dti-1337	1	8	1–8	1–8	SYM
dti-1337	1	9	1	1	NUM
dti-1337	1	10	original	original	ADJ
dti-1337	1	11	research	research	NOUN
dti-1337	1	12	correspondence	correspondence	NOUN
dti-1337	1	13	:	:	PUNCT
dti-1337	1	14	asher	asher	PROPN
dti-1337	1	15	begleiter	begleiter	PROPN
dti-1337	1	16	,	,	PUNCT
dti-1337	1	17	manitoba	manitoba	PROPN
dti-1337	1	18	institute	institute	PROPN
dti-1337	1	19	of	of	ADP
dti-1337	1	20	cell	cell	NOUN
dti-1337	1	21	biology	biology	NOUN
dti-1337	1	22	,	,	PUNCT
dti-1337	1	23	cancercare	cancercare	PROPN
dti-1337	1	24	manitoba	manitoba	PROPN
dti-1337	1	25	,	,	PUNCT
dti-1337	1	26	departments	department	NOUN
dti-1337	1	27	of	of	ADP
dti-1337	1	28	internal	internal	ADJ
dti-1337	1	29	medicine	medicine	NOUN
dti-1337	1	30	and	and	CCONJ
dti-1337	1	31	pharmacology	pharmacology	NOUN
dti-1337	1	32	and	and	CCONJ
dti-1337	1	33	therapeutics	therapeutic	NOUN
dti-1337	1	34	,	,	PUNCT
dti-1337	1	35	university	university	NOUN
dti-1337	1	36	of	of	ADP
dti-1337	1	37	manitoba	manitoba	PROPN
dti-1337	1	38	,	,	PUNCT
dti-1337	1	39	675	675	NUM
dti-1337	1	40	mcdermot	mcdermot	PROPN
dti-1337	1	41	avenue	avenue	PROPN
dti-1337	1	42	,	,	PUNCT
dti-1337	1	43	winnipeg	winnipeg	PROPN
dti-1337	1	44	,	,	PUNCT
dti-1337	1	45	manitoba	manitoba	PROPN
dti-1337	1	46	r3e	r3e	PROPN
dti-1337	1	47	0v9	0v9	X
dti-1337	2	1	canada	canada	PROPN
dti-1337	2	2	.	.	PUNCT
dti-1337	3	1	tel	tel	ADP
dti-1337	3	2	:	:	PUNCT
dti-1337	3	3	+1	+1	PROPN
dti-1337	3	4	-	-	PUNCT
dti-1337	3	5	204	204	NUM
dti-1337	3	6	-	-	PUNCT
dti-1337	3	7	787	787	NUM
dti-1337	3	8	-	-	PUNCT
dti-1337	3	9	2155	2155	NUM
dti-1337	3	10	;	;	PUNCT
dti-1337	3	11	fax	fax	NOUN
dti-1337	3	12	:	:	PUNCT
dti-1337	3	13	+1	+1	PROPN
dti-1337	3	14	-	-	PUNCT
dti-1337	3	15	204	204	NUM
dti-1337	3	16	-	-	PUNCT
dti-1337	3	17	787	787	NUM
dti-1337	3	18	-	-	PUNCT
dti-1337	3	19	2190	2190	NUM
dti-1337	3	20	;	;	PUNCT
dti-1337	3	21	email	email	NOUN
dti-1337	3	22	:	:	PUNCT
dti-1337	3	23	begleit@cc.umanitoba.ca	begleit@cc.umanitoba.ca	NOUN
dti-1337	3	24	copyright	copyright	NOUN
dti-1337	3	25	in	in	ADP
dti-1337	3	26	this	this	DET
dti-1337	3	27	article	article	NOUN
dti-1337	3	28	,	,	PUNCT
dti-1337	3	29	its	its	PRON
dti-1337	3	30	metadata	metadata	NOUN
dti-1337	3	31	,	,	PUNCT
dti-1337	3	32	and	and	CCONJ
dti-1337	3	33	any	any	DET
dti-1337	3	34	supplementary	supplementary	ADJ
dti-1337	3	35	data	datum	NOUN
dti-1337	3	36	is	be	AUX
dti-1337	3	37	held	hold	VERB
dti-1337	3	38	by	by	ADP
dti-1337	3	39	its	its	PRON
dti-1337	3	40	author	author	NOUN
dti-1337	3	41	or	or	CCONJ
dti-1337	3	42	authors	author	NOUN
dti-1337	3	43	.	.	PUNCT
dti-1337	4	1	it	it	PRON
dti-1337	4	2	is	be	AUX
dti-1337	4	3	published	publish	VERB
dti-1337	4	4	under	under	ADP
dti-1337	4	5	the	the	DET
dti-1337	4	6	creative	creative	ADJ
dti-1337	4	7	commons	common	NOUN
dti-1337	4	8	attribution	attribution	NOUN
dti-1337	4	9	by	by	ADP
dti-1337	4	10	licence	licence	NOUN
dti-1337	4	11	.	.	PUNCT
dti-1337	5	1	for	for	SCONJ
dti-1337	5	2	further	further	ADJ
dti-1337	5	3	information	information	NOUN
dti-1337	5	4	go	go	VERB
dti-1337	5	5	to	to	ADP
dti-1337	5	6	:	:	PUNCT
dti-1337	5	7	http://creativecommons.org/licenses/by/3.0/.	http://creativecommons.org/licenses/by/3.0/.	VERB
dti-1337	5	8	a	a	DET
dti-1337	5	9	model	model	NOUN
dti-1337	5	10	for	for	ADP
dti-1337	5	11	nad(p)h	nad(p)h	NOUN
dti-1337	5	12	:	:	PUNCT
dti-1337	5	13	quinoneoxidoreductase	quinoneoxidoreductase	NOUN
dti-1337	5	14	1	1	NUM
dti-1337	5	15	(	(	PUNCT
dti-1337	5	16	nqo1	nqo1	PROPN
dti-1337	5	17	)	)	PUNCT
dti-1337	5	18	targeted	target	VERB
dti-1337	5	19	individualized	individualized	ADJ
dti-1337	5	20	cancer	cancer	NOUN
dti-1337	5	21	chemotherapy	chemotherapy	NOUN
dti-1337	5	22	asher	asher	PROPN
dti-1337	5	23	begleiter1	begleiter1	PROPN
dti-1337	5	24	,	,	PUNCT
dti-1337	5	25	nadia	nadia	PROPN
dti-1337	5	26	el	el	PROPN
dti-1337	5	27	-	-	PUNCT
dti-1337	5	28	gabalawy2	gabalawy2	NOUN
dti-1337	5	29	,	,	PUNCT
dti-1337	5	30	laurie	laurie	PROPN
dti-1337	5	31	lange2	lange2	PROPN
dti-1337	5	32	,	,	PUNCT
dti-1337	5	33	marsha	marsha	PROPN
dti-1337	5	34	k.	k.	PROPN
dti-1337	5	35	leith2	leith2	PROPN
dti-1337	5	36	,	,	PUNCT
dti-1337	5	37	lynn	lynn	PROPN
dti-1337	5	38	j.	j.	PROPN
dti-1337	5	39	guziec3	guziec3	PROPN
dti-1337	5	40	and	and	CCONJ
dti-1337	5	41	frank	frank	PROPN
dti-1337	5	42	s.	s.	PROPN
dti-1337	5	43	guziec	guziec	PROPN
dti-1337	5	44	jr3	jr3	PROPN
dti-1337	6	1	1manitoba	1manitoba	NUM
dti-1337	6	2	institute	institute	PROPN
dti-1337	6	3	of	of	ADP
dti-1337	6	4	cell	cell	NOUN
dti-1337	6	5	biology	biology	NOUN
dti-1337	6	6	,	,	PUNCT
dti-1337	6	7	cancercare	cancercare	PROPN
dti-1337	6	8	manitoba	manitoba	PROPN
dti-1337	6	9	,	,	PUNCT
dti-1337	6	10	departments	department	NOUN
dti-1337	6	11	of	of	ADP
dti-1337	6	12	internal	internal	ADJ
dti-1337	6	13	medicine	medicine	NOUN
dti-1337	6	14	and	and	CCONJ
dti-1337	6	15	pharmacology	pharmacology	NOUN
dti-1337	6	16	and	and	CCONJ
dti-1337	6	17	therapeutics	therapeutic	NOUN
dti-1337	6	18	,	,	PUNCT
dti-1337	6	19	university	university	NOUN
dti-1337	6	20	of	of	ADP
dti-1337	6	21	manitoba	manitoba	PROPN
dti-1337	6	22	,	,	PUNCT
dti-1337	6	23	675	675	NUM
dti-1337	6	24	mcdermot	mcdermot	PROPN
dti-1337	6	25	avenue	avenue	PROPN
dti-1337	6	26	,	,	PUNCT
dti-1337	6	27	winnipeg	winnipeg	PROPN
dti-1337	6	28	,	,	PUNCT
dti-1337	6	29	manitoba	manitoba	PROPN
dti-1337	6	30	r3e	r3e	PROPN
dti-1337	6	31	0v9	0v9	X
dti-1337	7	1	canada	canada	PROPN
dti-1337	7	2	.	.	PUNCT
dti-1337	8	1	2manitoba	2manitoba	NUM
dti-1337	8	2	institute	institute	PROPN
dti-1337	8	3	of	of	ADP
dti-1337	8	4	cell	cell	NOUN
dti-1337	8	5	biology	biology	NOUN
dti-1337	8	6	,	,	PUNCT
dti-1337	8	7	cancercare	cancercare	PROPN
dti-1337	8	8	manitoba	manitoba	PROPN
dti-1337	8	9	,	,	PUNCT
dti-1337	8	10	675	675	NUM
dti-1337	8	11	mcdermot	mcdermot	PROPN
dti-1337	8	12	avenue	avenue	PROPN
dti-1337	8	13	,	,	PUNCT
dti-1337	8	14	winnipeg	winnipeg	PROPN
dti-1337	8	15	,	,	PUNCT
dti-1337	8	16	manitoba	manitoba	PROPN
dti-1337	8	17	r3e	r3e	PROPN
dti-1337	8	18	0v9	0v9	X
dti-1337	9	1	canada	canada	PROPN
dti-1337	9	2	.	.	PUNCT
dti-1337	10	1	3department	3department	NUM
dti-1337	10	2	of	of	ADP
dti-1337	10	3	chemistry	chemistry	NOUN
dti-1337	10	4	and	and	CCONJ
dti-1337	10	5	biochemistry	biochemistry	NOUN
dti-1337	10	6	,	,	PUNCT
dti-1337	10	7	southwestern	southwestern	ADJ
dti-1337	10	8	university	university	NOUN
dti-1337	10	9	,	,	PUNCT
dti-1337	10	10	georgetown	georgetown	PROPN
dti-1337	10	11	,	,	PUNCT
dti-1337	10	12	texas	texas	PROPN
dti-1337	10	13	78628	78628	NUM
dti-1337	10	14	u.s.a	u.s.a	NOUN
dti-1337	10	15	.	.	PUNCT
dti-1337	11	1	abstract	abstract	PROPN
dti-1337	11	2	:	:	PUNCT
dti-1337	11	3	nqo1	nqo1	PROPN
dti-1337	11	4	(	(	PUNCT
dti-1337	11	5	nad(p)h	nad(p)h	NOUN
dti-1337	11	6	:	:	PUNCT
dti-1337	11	7	quinoneoxidoreductase	quinoneoxidoreductase	NOUN
dti-1337	11	8	1	1	NUM
dti-1337	11	9	)	)	PUNCT
dti-1337	11	10	is	be	AUX
dti-1337	11	11	a	a	DET
dti-1337	11	12	reductive	reductive	ADJ
dti-1337	11	13	enzyme	enzyme	NOUN
dti-1337	11	14	that	that	PRON
dti-1337	11	15	is	be	AUX
dti-1337	11	16	an	an	DET
dti-1337	11	17	important	important	ADJ
dti-1337	11	18	activator	activator	NOUN
dti-1337	11	19	of	of	ADP
dti-1337	11	20	bioreductive	bioreductive	ADJ
dti-1337	11	21	antitumor	antitumor	PROPN
dti-1337	11	22	agents	agent	NOUN
dti-1337	11	23	.	.	PUNCT
dti-1337	12	1	nqo1	nqo1	NOUN
dti-1337	12	2	activity	activity	NOUN
dti-1337	12	3	varies	vary	VERB
dti-1337	12	4	in	in	ADP
dti-1337	12	5	individual	individual	ADJ
dti-1337	12	6	tumors	tumor	NOUN
dti-1337	12	7	but	but	CCONJ
dti-1337	12	8	is	be	AUX
dti-1337	12	9	generally	generally	ADV
dti-1337	12	10	higher	high	ADJ
dti-1337	12	11	in	in	ADP
dti-1337	12	12	tumor	tumor	NOUN
dti-1337	12	13	cells	cell	NOUN
dti-1337	12	14	than	than	ADP
dti-1337	12	15	in	in	ADP
dti-1337	12	16	normal	normal	ADJ
dti-1337	12	17	cells	cell	NOUN
dti-1337	12	18	.	.	PUNCT
dti-1337	13	1	nqo1	nqo1	PROPN
dti-1337	13	2	has	have	AUX
dti-1337	13	3	been	be	AUX
dti-1337	13	4	used	use	VERB
dti-1337	13	5	as	as	ADP
dti-1337	13	6	a	a	DET
dti-1337	13	7	target	target	NOUN
dti-1337	13	8	for	for	ADP
dti-1337	13	9	tumor	tumor	NOUN
dti-1337	13	10	specifi	specifi	PROPN
dti-1337	13	11	c	c	PROPN
dti-1337	13	12	drug	drug	PROPN
dti-1337	13	13	development	development	NOUN
dti-1337	13	14	.	.	PUNCT
dti-1337	14	1	we	we	PRON
dti-1337	14	2	investigated	investigate	VERB
dti-1337	14	3	a	a	DET
dti-1337	14	4	series	series	NOUN
dti-1337	14	5	of	of	ADP
dti-1337	14	6	bioreductive	bioreductive	ADJ
dti-1337	14	7	benzoquinone	benzoquinone	NOUN
dti-1337	14	8	mustard	mustard	NOUN
dti-1337	14	9	analogs	analog	NOUN
dti-1337	14	10	as	as	ADP
dti-1337	14	11	a	a	DET
dti-1337	14	12	model	model	NOUN
dti-1337	14	13	for	for	ADP
dti-1337	14	14	nqo1	nqo1	NOUN
dti-1337	14	15	targeted	target	VERB
dti-1337	14	16	individualized	individualized	ADJ
dti-1337	14	17	cancer	cancer	NOUN
dti-1337	14	18	chemotherapy	chemotherapy	NOUN
dti-1337	14	19	.	.	PUNCT
dti-1337	15	1	we	we	PRON
dti-1337	15	2	compared	compare	VERB
dti-1337	15	3	the	the	DET
dti-1337	15	4	tumor	tumor	NOUN
dti-1337	15	5	cell	cell	NOUN
dti-1337	15	6	growth	growth	NOUN
dti-1337	15	7	inhibitory	inhibitory	ADJ
dti-1337	15	8	activity	activity	NOUN
dti-1337	15	9	of	of	ADP
dti-1337	15	10	benzoquinone	benzoquinone	NOUN
dti-1337	15	11	mustard	mustard	NOUN
dti-1337	15	12	analogs	analog	NOUN
dti-1337	15	13	with	with	ADP
dti-1337	15	14	sterically	sterically	ADV
dti-1337	15	15	bulky	bulky	ADJ
dti-1337	15	16	groups	group	NOUN
dti-1337	15	17	of	of	ADP
dti-1337	15	18	different	different	ADJ
dti-1337	15	19	size	size	NOUN
dti-1337	15	20	and	and	CCONJ
dti-1337	15	21	placed	place	VERB
dti-1337	15	22	at	at	ADP
dti-1337	15	23	different	different	ADJ
dti-1337	15	24	positions	position	NOUN
dti-1337	15	25	on	on	ADP
dti-1337	15	26	the	the	DET
dti-1337	15	27	benzoquinone	benzoquinone	NOUN
dti-1337	15	28	ring	ring	NOUN
dti-1337	15	29	,	,	PUNCT
dti-1337	15	30	using	use	VERB
dti-1337	15	31	tumor	tumor	NOUN
dti-1337	15	32	cell	cell	NOUN
dti-1337	15	33	lines	line	NOUN
dti-1337	15	34	with	with	ADP
dti-1337	15	35	different	different	ADJ
dti-1337	15	36	levels	level	NOUN
dti-1337	15	37	of	of	ADP
dti-1337	15	38	nqo1	nqo1	PROPN
dti-1337	15	39	.	.	PUNCT
dti-1337	16	1	we	we	PRON
dti-1337	16	2	demonstrated	demonstrate	VERB
dti-1337	16	3	that	that	SCONJ
dti-1337	16	4	functional	functional	ADJ
dti-1337	16	5	groups	group	NOUN
dti-1337	16	6	of	of	ADP
dti-1337	16	7	different	different	ADJ
dti-1337	16	8	steric	steric	ADJ
dti-1337	16	9	size	size	NOUN
dti-1337	16	10	could	could	AUX
dti-1337	16	11	be	be	AUX
dti-1337	16	12	used	use	VERB
dti-1337	16	13	to	to	PART
dti-1337	16	14	produce	produce	VERB
dti-1337	16	15	a	a	DET
dti-1337	16	16	series	series	NOUN
dti-1337	16	17	of	of	ADP
dti-1337	16	18	bioreductive	bioreductive	ADJ
dti-1337	16	19	antitumor	antitumor	PROPN
dti-1337	16	20	agents	agent	NOUN
dti-1337	16	21	that	that	PRON
dti-1337	16	22	were	be	AUX
dti-1337	16	23	activated	activate	VERB
dti-1337	16	24	by	by	ADP
dti-1337	16	25	different	different	ADJ
dti-1337	16	26	levels	level	NOUN
dti-1337	16	27	of	of	ADP
dti-1337	16	28	nqo1	nqo1	PROPN
dti-1337	16	29	in	in	ADP
dti-1337	16	30	tumor	tumor	NOUN
dti-1337	16	31	cells	cell	NOUN
dti-1337	16	32	.	.	PUNCT
dti-1337	17	1	this	this	DET
dti-1337	17	2	series	series	NOUN
dti-1337	17	3	of	of	ADP
dti-1337	17	4	drugs	drug	NOUN
dti-1337	17	5	could	could	AUX
dti-1337	17	6	then	then	ADV
dti-1337	17	7	be	be	AUX
dti-1337	17	8	used	use	VERB
dti-1337	17	9	to	to	PART
dti-1337	17	10	target	target	VERB
dti-1337	17	11	cells	cell	NOUN
dti-1337	17	12	with	with	ADP
dti-1337	17	13	specifi	specifi	PROPN
dti-1337	17	14	c	c	PROPN
dti-1337	17	15	levels	level	NOUN
dti-1337	17	16	of	of	ADP
dti-1337	17	17	nqo1	nqo1	NOUN
dti-1337	17	18	for	for	ADP
dti-1337	17	19	growth	growth	NOUN
dti-1337	17	20	inhibition	inhibition	NOUN
dti-1337	17	21	and	and	CCONJ
dti-1337	17	22	to	to	PART
dti-1337	17	23	avoid	avoid	VERB
dti-1337	17	24	damage	damage	NOUN
dti-1337	17	25	to	to	ADP
dti-1337	17	26	normal	normal	ADJ
dti-1337	17	27	cells	cell	NOUN
dti-1337	17	28	,	,	PUNCT
dti-1337	17	29	like	like	ADP
dti-1337	17	30	bone	bone	NOUN
dti-1337	17	31	marrow	marrow	NOUN
dti-1337	17	32	cells	cell	NOUN
dti-1337	17	33	,	,	PUNCT
dti-1337	17	34	that	that	PRON
dti-1337	17	35	have	have	VERB
dti-1337	17	36	low	low	ADJ
dti-1337	17	37	levels	level	NOUN
dti-1337	17	38	of	of	ADP
dti-1337	17	39	nqo1	nqo1	PROPN
dti-1337	17	40	.	.	PUNCT
dti-1337	18	1	this	this	DET
dti-1337	18	2	approach	approach	NOUN
dti-1337	18	3	could	could	AUX
dti-1337	18	4	be	be	AUX
dti-1337	18	5	used	use	VERB
dti-1337	18	6	to	to	PART
dti-1337	18	7	develop	develop	VERB
dti-1337	18	8	new	new	ADJ
dti-1337	18	9	bioreductive	bioreductive	ADJ
dti-1337	18	10	antitumor	antitumor	PROPN
dti-1337	18	11	agents	agent	NOUN
dti-1337	18	12	for	for	ADP
dti-1337	18	13	nqo1	nqo1	PROPN
dti-1337	18	14	targeted	target	VERB
dti-1337	18	15	individualized	individualized	ADJ
dti-1337	18	16	cancer	cancer	NOUN
dti-1337	18	17	chemotherapy	chemotherapy	NOUN
dti-1337	18	18	.	.	PUNCT
dti-1337	19	1	keywords	keyword	NOUN
dti-1337	19	2	:	:	PUNCT
dti-1337	19	3	individualized	individualized	ADJ
dti-1337	19	4	cancer	cancer	NOUN
dti-1337	19	5	chemotherapy	chemotherapy	NOUN
dti-1337	19	6	,	,	PUNCT
dti-1337	19	7	tumor	tumor	NOUN
dti-1337	19	8	targeting	targeting	NOUN
dti-1337	19	9	,	,	PUNCT
dti-1337	19	10	bioreductive	bioreductive	ADJ
dti-1337	19	11	agents	agent	NOUN
dti-1337	19	12	,	,	PUNCT
dti-1337	19	13	nqo1	nqo1	PROPN
dti-1337	19	14	,	,	PUNCT
dti-1337	19	15	benzoquinone	benzoquinone	NOUN
dti-1337	19	16	mustard	mustard	NOUN
dti-1337	19	17	introduction	introduction	NOUN
dti-1337	19	18	current	current	ADJ
dti-1337	19	19	anticancer	anticancer	NOUN
dti-1337	19	20	agents	agent	NOUN
dti-1337	19	21	are	be	AUX
dti-1337	19	22	generally	generally	ADV
dti-1337	19	23	potent	potent	ADJ
dti-1337	19	24	enough	enough	ADV
dti-1337	19	25	to	to	PART
dti-1337	19	26	kill	kill	VERB
dti-1337	19	27	most	most	ADJ
dti-1337	19	28	cancer	cancer	NOUN
dti-1337	19	29	cells	cell	NOUN
dti-1337	19	30	,	,	PUNCT
dti-1337	19	31	but	but	CCONJ
dti-1337	19	32	their	their	PRON
dti-1337	19	33	use	use	NOUN
dti-1337	19	34	is	be	AUX
dti-1337	19	35	limited	limit	VERB
dti-1337	19	36	by	by	ADP
dti-1337	19	37	toxic	toxic	ADJ
dti-1337	19	38	side	side	NOUN
dti-1337	19	39	effects	effect	NOUN
dti-1337	19	40	.	.	PUNCT
dti-1337	20	1	similarities	similarity	NOUN
dti-1337	20	2	between	between	ADP
dti-1337	20	3	cancer	cancer	NOUN
dti-1337	20	4	and	and	CCONJ
dti-1337	20	5	normal	normal	ADJ
dti-1337	20	6	cells	cell	NOUN
dti-1337	20	7	result	result	VERB
dti-1337	20	8	in	in	ADP
dti-1337	20	9	a	a	DET
dti-1337	20	10	narrow	narrow	ADJ
dti-1337	20	11	therapeutic	therapeutic	ADJ
dti-1337	20	12	index	index	NOUN
dti-1337	20	13	.	.	PUNCT
dti-1337	21	1	the	the	DET
dti-1337	21	2	use	use	NOUN
dti-1337	21	3	of	of	ADP
dti-1337	21	4	chemotherapy	chemotherapy	NOUN
dti-1337	21	5	could	could	AUX
dti-1337	21	6	be	be	AUX
dti-1337	21	7	greatly	greatly	ADV
dti-1337	21	8	enhanced	enhance	VERB
dti-1337	21	9	by	by	ADP
dti-1337	21	10	new	new	ADJ
dti-1337	21	11	drugs	drug	NOUN
dti-1337	21	12	that	that	PRON
dti-1337	21	13	specifi	specifi	AUX
dti-1337	21	14	cally	cally	ADV
dti-1337	21	15	target	target	VERB
dti-1337	21	16	cancer	cancer	NOUN
dti-1337	21	17	cells	cell	NOUN
dti-1337	21	18	.	.	PUNCT
dti-1337	22	1	an	an	DET
dti-1337	22	2	important	important	ADJ
dti-1337	22	3	strategy	strategy	NOUN
dti-1337	22	4	to	to	PART
dti-1337	22	5	improve	improve	VERB
dti-1337	22	6	selectivity	selectivity	NOUN
dti-1337	22	7	of	of	ADP
dti-1337	22	8	anticancer	anticancer	NOUN
dti-1337	22	9	drugs	drug	NOUN
dti-1337	22	10	for	for	ADP
dti-1337	22	11	cancer	cancer	NOUN
dti-1337	22	12	cells	cell	NOUN
dti-1337	22	13	is	be	AUX
dti-1337	22	14	enzyme	enzyme	NOUN
dti-1337	22	15	-	-	PUNCT
dti-1337	22	16	directed	direct	VERB
dti-1337	22	17	tumor	tumor	NOUN
dti-1337	22	18	targeting.1,2	targeting.1,2	NOUN
dti-1337	22	19	in	in	ADP
dti-1337	22	20	this	this	DET
dti-1337	22	21	strategy	strategy	NOUN
dti-1337	22	22	drugs	drug	NOUN
dti-1337	22	23	activated	activate	VERB
dti-1337	22	24	by	by	ADP
dti-1337	22	25	a	a	DET
dti-1337	22	26	specifi	specifi	PROPN
dti-1337	22	27	c	c	PROPN
dti-1337	22	28	enzyme	enzyme	NOUN
dti-1337	22	29	are	be	AUX
dti-1337	22	30	used	use	VERB
dti-1337	22	31	to	to	PART
dti-1337	22	32	treat	treat	VERB
dti-1337	22	33	tumors	tumor	NOUN
dti-1337	22	34	with	with	ADP
dti-1337	22	35	high	high	ADJ
dti-1337	22	36	levels	level	NOUN
dti-1337	22	37	of	of	ADP
dti-1337	22	38	that	that	DET
dti-1337	22	39	enzyme	enzyme	NOUN
dti-1337	22	40	.	.	PUNCT
dti-1337	23	1	bioreductive	bioreductive	ADJ
dti-1337	23	2	agents	agent	NOUN
dti-1337	23	3	are	be	AUX
dti-1337	23	4	a	a	DET
dti-1337	23	5	class	class	NOUN
dti-1337	23	6	of	of	ADP
dti-1337	23	7	anticancer	anticancer	NOUN
dti-1337	23	8	drugs	drug	NOUN
dti-1337	23	9	that	that	PRON
dti-1337	23	10	must	must	AUX
dti-1337	23	11	be	be	AUX
dti-1337	23	12	activated	activate	VERB
dti-1337	23	13	in	in	ADP
dti-1337	23	14	cells	cell	NOUN
dti-1337	23	15	by	by	ADP
dti-1337	23	16	reductive	reductive	ADJ
dti-1337	23	17	enzymes	enzyme	NOUN
dti-1337	23	18	.	.	PUNCT
dti-1337	24	1	these	these	DET
dti-1337	24	2	agents	agent	NOUN
dti-1337	24	3	are	be	AUX
dti-1337	24	4	preferentially	preferentially	ADV
dti-1337	24	5	active	active	ADJ
dti-1337	24	6	in	in	ADP
dti-1337	24	7	solid	solid	ADJ
dti-1337	24	8	tumors	tumor	NOUN
dti-1337	24	9	,	,	PUNCT
dti-1337	24	10	which	which	PRON
dti-1337	24	11	represent	represent	VERB
dti-1337	24	12	the	the	DET
dti-1337	24	13	majority	majority	NOUN
dti-1337	24	14	of	of	ADP
dti-1337	24	15	cancers	cancer	NOUN
dti-1337	24	16	and	and	CCONJ
dti-1337	24	17	produce	produce	VERB
dti-1337	24	18	the	the	DET
dti-1337	24	19	highest	high	ADJ
dti-1337	24	20	mortality	mortality	NOUN
dti-1337	24	21	.	.	PUNCT
dti-1337	25	1	the	the	DET
dti-1337	25	2	clinical	clinical	ADJ
dti-1337	25	3	potential3,4	potential3,4	ADJ
dti-1337	25	4	and	and	CCONJ
dti-1337	25	5	mode	mode	NOUN
dti-1337	25	6	of	of	ADP
dti-1337	25	7	action5,6	action5,6	PROPN
dti-1337	25	8	of	of	ADP
dti-1337	25	9	these	these	DET
dti-1337	25	10	agents	agent	NOUN
dti-1337	25	11	have	have	AUX
dti-1337	25	12	been	be	AUX
dti-1337	25	13	actively	actively	ADV
dti-1337	25	14	studied	study	VERB
dti-1337	25	15	,	,	PUNCT
dti-1337	25	16	and	and	CCONJ
dti-1337	25	17	the	the	DET
dti-1337	25	18	use	use	NOUN
dti-1337	25	19	of	of	ADP
dti-1337	25	20	the	the	DET
dti-1337	25	21	prototype	prototype	NOUN
dti-1337	25	22	drug	drug	NOUN
dti-1337	25	23	mitomycin	mitomycin	PROPN
dti-1337	25	24	c	c	PROPN
dti-1337	25	25	(	(	PUNCT
dti-1337	25	26	mmc	mmc	PROPN
dti-1337	25	27	)	)	PUNCT
dti-1337	25	28	in	in	ADP
dti-1337	25	29	the	the	DET
dti-1337	25	30	clinic	clinic	NOUN
dti-1337	25	31	has	have	AUX
dti-1337	25	32	been	be	AUX
dti-1337	25	33	reviewed.7	reviewed.7	NOUN
dti-1337	25	34	other	other	ADJ
dti-1337	25	35	agents	agent	NOUN
dti-1337	25	36	like	like	ADP
dti-1337	25	37	porfi	porfi	VERB
dti-1337	25	38	romycin	romycin	PROPN
dti-1337	25	39	,	,	PUNCT
dti-1337	25	40	diaziquone	diaziquone	NOUN
dti-1337	25	41	(	(	PUNCT
dti-1337	25	42	azq	azq	PROPN
dti-1337	25	43	)	)	PUNCT
dti-1337	25	44	,	,	PUNCT
dti-1337	25	45	3	3	NUM
dti-1337	25	46	-	-	SYM
dti-1337	25	47	hydroxymethyl-5	hydroxymethyl-5	NUM
dti-1337	25	48	-	-	PUNCT
dti-1337	25	49	aziridinyl-1	aziridinyl-1	NOUN
dti-1337	25	50	-	-	PUNCT
dti-1337	25	51	methyl2-(1h	methyl2-(1h	NOUN
dti-1337	25	52	-	-	PUNCT
dti-1337	25	53	indole-4,7	indole-4,7	NOUN
dti-1337	25	54	-	-	PUNCT
dti-1337	25	55	dione)prop	dione)prop	NOUN
dti-1337	25	56	-	-	PUNCT
dti-1337	25	57	β	β	NOUN
dti-1337	25	58	-	-	PUNCT
dti-1337	25	59	en	en	X
dti-1337	25	60	-	-	PUNCT
dti-1337	25	61	α	α	NOUN
dti-1337	25	62	-	-	PUNCT
dti-1337	25	63	ol	ol	PROPN
dti-1337	25	64	(	(	PUNCT
dti-1337	25	65	eo9	eo9	PROPN
dti-1337	25	66	)	)	PUNCT
dti-1337	25	67	,	,	PUNCT
dti-1337	25	68	tirapazamine	tirapazamine	NOUN
dti-1337	25	69	(	(	PUNCT
dti-1337	25	70	tpz	tpz	NOUN
dti-1337	25	71	)	)	PUNCT
dti-1337	25	72	and	and	CCONJ
dti-1337	25	73	2,5	2,5	NUM
dti-1337	25	74	-	-	PUNCT
dti-1337	25	75	diaziridinyl-3(hydroxymethyl)-6	diaziridinyl-3(hydroxymethyl)-6	ADP
dti-1337	25	76	-	-	PUNCT
dti-1337	25	77	methyl-1,4	methyl-1,4	NOUN
dti-1337	25	78	-	-	PUNCT
dti-1337	25	79	benzoquinone	benzoquinone	NOUN
dti-1337	25	80	(	(	PUNCT
dti-1337	25	81	rh1	rh1	X
dti-1337	25	82	)	)	PUNCT
dti-1337	25	83	have	have	AUX
dti-1337	25	84	been	be	AUX
dti-1337	25	85	tested	test	VERB
dti-1337	25	86	clinically,7–15	clinically,7–15	NOUN
dti-1337	25	87	and	and	CCONJ
dti-1337	25	88	there	there	PRON
dti-1337	25	89	is	be	VERB
dti-1337	25	90	also	also	ADV
dti-1337	25	91	ongoing	ongoing	ADJ
dti-1337	25	92	work	work	NOUN
dti-1337	25	93	to	to	PART
dti-1337	25	94	develop	develop	VERB
dti-1337	25	95	new	new	ADJ
dti-1337	25	96	agents.16,17	agents.16,17	NOUN
dti-1337	25	97	these	these	DET
dti-1337	25	98	drugs	drug	NOUN
dti-1337	25	99	are	be	AUX
dti-1337	25	100	potent	potent	ADJ
dti-1337	25	101	antitumor	antitumor	PROPN
dti-1337	25	102	agents	agent	NOUN
dti-1337	25	103	,	,	PUNCT
dti-1337	25	104	but	but	CCONJ
dti-1337	25	105	produce	produce	VERB
dti-1337	25	106	a	a	DET
dti-1337	25	107	variety	variety	NOUN
dti-1337	25	108	of	of	ADP
dti-1337	25	109	side	side	NOUN
dti-1337	25	110	effects	effect	NOUN
dti-1337	25	111	including	include	VERB
dti-1337	25	112	lung,7,18	lung,7,18	PROPN
dti-1337	25	113	hearing	hearing	NOUN
dti-1337	25	114	,	,	PUNCT
dti-1337	25	115	muscle	muscle	NOUN
dti-1337	25	116	and	and	CCONJ
dti-1337	25	117	renal	renal	ADJ
dti-1337	25	118	toxicity.10,12	toxicity.10,12	NOUN
dti-1337	25	119	however	however	ADV
dti-1337	25	120	,	,	PUNCT
dti-1337	25	121	marrow	marrow	NOUN
dti-1337	25	122	toxicity	toxicity	NOUN
dti-1337	25	123	is	be	AUX
dti-1337	25	124	often	often	ADV
dti-1337	25	125	the	the	DET
dti-1337	25	126	dose	dose	NOUN
dti-1337	25	127	limiting	limit	VERB
dti-1337	25	128	toxicity	toxicity	NOUN
dti-1337	25	129	for	for	ADP
dti-1337	25	130	these	these	PRON
dti-1337	25	131	agents.7,9,10,19	agents.7,9,10,19	INTJ
dti-1337	25	132	bioreductive	bioreductive	ADJ
dti-1337	25	133	agents	agent	NOUN
dti-1337	25	134	can	can	AUX
dti-1337	25	135	be	be	AUX
dti-1337	25	136	activated	activate	VERB
dti-1337	25	137	by	by	ADP
dti-1337	25	138	two	two	NUM
dti-1337	25	139	electron	electron	NOUN
dti-1337	25	140	reducing	reduce	VERB
dti-1337	25	141	enzymes	enzyme	NOUN
dti-1337	25	142	like	like	ADP
dti-1337	25	143	nad(p)h	nad(p)h	NOUN
dti-1337	25	144	:	:	PUNCT
dti-1337	25	145	quinoneoxidoreductase	quinoneoxidoreductase	NOUN
dti-1337	25	146	1	1	NUM
dti-1337	25	147	(	(	PUNCT
dti-1337	25	148	nqo1	nqo1	PROPN
dti-1337	25	149	;	;	PUNCT
dti-1337	25	150	dt	dt	NOUN
dti-1337	25	151	-	-	PUNCT
dti-1337	25	152	diaphorase)1,20	diaphorase)1,20	NOUN
dti-1337	25	153	or	or	CCONJ
dti-1337	25	154	one	one	NUM
dti-1337	25	155	electron	electron	NOUN
dti-1337	25	156	reducing	reduce	VERB
dti-1337	25	157	enzymes	enzyme	NOUN
dti-1337	25	158	like	like	ADP
dti-1337	25	159	nadph	nadph	ADJ
dti-1337	25	160	cytochrome	cytochrome	NOUN
dti-1337	25	161	p450	p450	ADJ
dti-1337	25	162	reductase	reductase	NOUN
dti-1337	25	163	(	(	PUNCT
dti-1337	25	164	p450	p450	PROPN
dti-1337	25	165	red).5,21	red).5,21	VERB
dti-1337	25	166	nqo1	nqo1	NOUN
dti-1337	25	167	is	be	AUX
dti-1337	25	168	a	a	DET
dti-1337	25	169	fl	fl	NOUN
dti-1337	25	170	avoprotein	avoprotein	NOUN
dti-1337	25	171	that	that	SCONJ
dti-1337	25	172	catalyzes	catalyze	VERB
dti-1337	25	173	2	2	NUM
dti-1337	25	174	-	-	PUNCT
dti-1337	25	175	electron	electron	NOUN
dti-1337	25	176	reduction	reduction	NOUN
dti-1337	25	177	of	of	ADP
dti-1337	25	178	quinones	quinone	NOUN
dti-1337	25	179	and	and	CCONJ
dti-1337	25	180	n	n	CCONJ
dti-1337	25	181	-	-	PUNCT
dti-1337	25	182	oxides.1	oxides.1	VERB
dti-1337	25	183	several	several	ADJ
dti-1337	25	184	human	human	ADJ
dti-1337	25	185	diaphorases	diaphorase	NOUN
dti-1337	25	186	are	be	AUX
dti-1337	25	187	known,1,22,23	known,1,22,23	PROPN
dti-1337	25	188	but	but	CCONJ
dti-1337	25	189	nqo1	nqo1	PROPN
dti-1337	25	190	appears	appear	VERB
dti-1337	25	191	to	to	PART
dti-1337	25	192	be	be	AUX
dti-1337	25	193	most	most	ADV
dti-1337	25	194	important	important	ADJ
dti-1337	25	195	for	for	ADP
dti-1337	25	196	activating	activate	VERB
dti-1337	25	197	bioreductive	bioreductive	ADJ
dti-1337	25	198	agents.1,22,24	agents.1,22,24	PROPN
dti-1337	25	199	nqo1	nqo1	PROPN
dti-1337	25	200	is	be	AUX
dti-1337	25	201	a	a	DET
dti-1337	25	202	homodimer	homodimer	NOUN
dti-1337	25	203	that	that	PRON
dti-1337	25	204	uses	use	VERB
dti-1337	25	205	nad(p)h	nad(p)h	NOUN
dti-1337	25	206	as	as	ADP
dti-1337	25	207	an	an	DET
dti-1337	25	208	electron	electron	NOUN
dti-1337	25	209	donor.1	donor.1	VERB
dti-1337	25	210	the	the	DET
dti-1337	25	211	enzyme	enzyme	NOUN
dti-1337	25	212	is	be	AUX
dti-1337	25	213	mainly	mainly	ADV
dti-1337	25	214	cytosolic	cytosolic	ADJ
dti-1337	25	215	,	,	PUNCT
dti-1337	25	216	but	but	CCONJ
dti-1337	25	217	a	a	DET
dti-1337	25	218	signifi	signifi	NOUN
dti-1337	25	219	ca	can	AUX
dti-1337	25	220	nt	not	PART
dti-1337	25	221	proportion	proportion	VERB
dti-1337	25	222	of	of	ADP
dti-1337	25	223	the	the	DET
dti-1337	25	224	enzyme	enzyme	NOUN
dti-1337	25	225	is	be	AUX
dti-1337	25	226	present	present	ADJ
dti-1337	25	227	in	in	ADP
dti-1337	25	228	the	the	DET
dti-1337	25	229	nucleus	nucleus	NOUN
dti-1337	25	230	of	of	ADP
dti-1337	25	231	cancer	cancer	NOUN
dti-1337	25	232	cells.25	cells.25	PROPN
dti-1337	25	233	it	it	PRON
dti-1337	25	234	is	be	AUX
dti-1337	25	235	ubiquitous	ubiquitous	ADJ
dti-1337	25	236	in	in	ADP
dti-1337	25	237	eukaryotes	eukaryote	NOUN
dti-1337	25	238	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1337	25	239	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
dti-1337	25	240	2	2	NUM
dti-1337	25	241	begleiter	begleiter	NOUN
dti-1337	25	242	et	et	PROPN
dti-1337	25	243	al	al	PROPN
dti-1337	25	244	drug	drug	PROPN
dti-1337	25	245	target	target	NOUN
dti-1337	25	246	insights	insight	NOUN
dti-1337	25	247	2009:4	2009:4	NUM
dti-1337	25	248	but	but	CCONJ
dti-1337	25	249	levels	level	NOUN
dti-1337	25	250	vary	vary	VERB
dti-1337	25	251	in	in	ADP
dti-1337	25	252	different	different	ADJ
dti-1337	25	253	tissues,1,24,26	tissues,1,24,26	NOUN
dti-1337	25	254	with	with	ADP
dti-1337	25	255	low	low	ADJ
dti-1337	25	256	levels	level	NOUN
dti-1337	25	257	in	in	ADP
dti-1337	25	258	hematopoetic	hematopoetic	ADJ
dti-1337	25	259	cells.26	cells.26	NOUN
dti-1337	25	260	activity	activity	NOUN
dti-1337	25	261	is	be	AUX
dti-1337	25	262	usually	usually	ADV
dti-1337	25	263	higher	high	ADJ
dti-1337	25	264	in	in	ADP
dti-1337	25	265	tumor	tumor	NOUN
dti-1337	25	266	than	than	SCONJ
dti-1337	25	267	normal	normal	ADJ
dti-1337	25	268	cells.24,26,26	cells.24,26,26	ADJ
dti-1337	25	269	nqo1	nqo1	PROPN
dti-1337	25	270	has	have	AUX
dti-1337	25	271	been	be	AUX
dti-1337	25	272	shown	show	VERB
dti-1337	25	273	to	to	PART
dti-1337	25	274	play	play	VERB
dti-1337	25	275	a	a	DET
dti-1337	25	276	role	role	NOUN
dti-1337	25	277	in	in	ADP
dti-1337	25	278	the	the	DET
dti-1337	25	279	activation	activation	NOUN
dti-1337	25	280	of	of	ADP
dti-1337	25	281	cancer	cancer	NOUN
dti-1337	25	282	chemotherapeutic	chemotherapeutic	NOUN
dti-1337	25	283	agents,1,20,28	agents,1,20,28	X
dti-1337	25	284	detoxifi	detoxifi	NOUN
dti-1337	25	285	cation	cation	NOUN
dti-1337	25	286	of	of	ADP
dti-1337	25	287	xenobiotics29	xenobiotics29	ADJ
dti-1337	25	288	and	and	CCONJ
dti-1337	25	289	cancer	cancer	NOUN
dti-1337	25	290	prevention.20,28	prevention.20,28	NOUN
dti-1337	25	291	activation	activation	NOUN
dti-1337	25	292	of	of	ADP
dti-1337	25	293	bioreductive	bioreductive	ADJ
dti-1337	25	294	agents	agent	NOUN
dti-1337	25	295	by	by	ADP
dti-1337	25	296	nqo1	nqo1	PROPN
dti-1337	25	297	has	have	AUX
dti-1337	25	298	been	be	AUX
dti-1337	25	299	extensively	extensively	ADV
dti-1337	25	300	studied.1,20	studied.1,20	NOUN
dti-1337	25	301	cells	cell	NOUN
dti-1337	25	302	with	with	ADP
dti-1337	25	303	elevated	elevated	ADJ
dti-1337	25	304	nqo1	nqo1	NOUN
dti-1337	25	305	levels	level	NOUN
dti-1337	25	306	are	be	AUX
dti-1337	25	307	more	more	ADV
dti-1337	25	308	sensitive	sensitive	ADJ
dti-1337	25	309	to	to	ADP
dti-1337	25	310	mmc	mmc	NOUN
dti-1337	25	311	and	and	CCONJ
dti-1337	25	312	drug	drug	NOUN
dti-1337	25	313	activity	activity	NOUN
dti-1337	25	314	is	be	AUX
dti-1337	25	315	decreased	decrease	VERB
dti-1337	25	316	by	by	ADP
dti-1337	25	317	the	the	DET
dti-1337	25	318	nqo1	nqo1	PROPN
dti-1337	25	319	inhibitor	inhibitor	NOUN
dti-1337	25	320	,	,	PUNCT
dti-1337	25	321	dicoumarol.30–32	dicoumarol.30–32	NOUN
dti-1337	25	322	thus	thus	ADV
dti-1337	25	323	,	,	PUNCT
dti-1337	25	324	nqo1	nqo1	PROPN
dti-1337	25	325	is	be	AUX
dti-1337	25	326	a	a	DET
dti-1337	25	327	major	major	ADJ
dti-1337	25	328	activating	activate	VERB
dti-1337	25	329	enzyme	enzyme	NOUN
dti-1337	25	330	for	for	ADP
dti-1337	25	331	mmc	mmc	PROPN
dti-1337	25	332	.	.	PUNCT
dti-1337	26	1	nqo1	nqo1	PROPN
dti-1337	26	2	is	be	AUX
dti-1337	26	3	also	also	ADV
dti-1337	26	4	the	the	DET
dti-1337	26	5	major	major	ADJ
dti-1337	26	6	activating	activate	VERB
dti-1337	26	7	enzyme	enzyme	NOUN
dti-1337	26	8	for	for	ADP
dti-1337	26	9	eo9	eo9	NOUN
dti-1337	26	10	,	,	PUNCT
dti-1337	26	11	2,5	2,5	NUM
dti-1337	26	12	-	-	PUNCT
dti-1337	26	13	diaziridinyl3,6	diaziridinyl3,6	PROPN
dti-1337	26	14	-	-	PUNCT
dti-1337	26	15	dimethyl-1,4	dimethyl-1,4	NOUN
dti-1337	26	16	-	-	PUNCT
dti-1337	26	17	benzoquinone	benzoquinone	NOUN
dti-1337	26	18	(	(	PUNCT
dti-1337	26	19	medzq	medzq	NOUN
dti-1337	26	20	)	)	PUNCT
dti-1337	26	21	and	and	CCONJ
dti-1337	26	22	rh1.1,4,14,33,34	rh1.1,4,14,33,34	NOUN
dti-1337	26	23	bioreductive	bioreductive	ADJ
dti-1337	26	24	agents	agent	NOUN
dti-1337	26	25	are	be	AUX
dti-1337	26	26	ideally	ideally	ADV
dti-1337	26	27	suited	suit	VERB
dti-1337	26	28	for	for	ADP
dti-1337	26	29	enzymedirected	enzymedirecte	VERB
dti-1337	26	30	tumor	tumor	NOUN
dti-1337	26	31	targeting	target	VERB
dti-1337	26	32	because	because	SCONJ
dti-1337	26	33	they	they	PRON
dti-1337	26	34	must	must	AUX
dti-1337	26	35	be	be	AUX
dti-1337	26	36	activated	activate	VERB
dti-1337	26	37	in	in	ADP
dti-1337	26	38	cells	cell	NOUN
dti-1337	26	39	by	by	ADP
dti-1337	26	40	reductive	reductive	ADJ
dti-1337	26	41	enzymes.1,2	enzymes.1,2	ADJ
dti-1337	26	42	nqo1	nqo1	NOUN
dti-1337	26	43	has	have	AUX
dti-1337	26	44	been	be	AUX
dti-1337	26	45	extensively	extensively	ADV
dti-1337	26	46	used	use	VERB
dti-1337	26	47	as	as	ADP
dti-1337	26	48	a	a	DET
dti-1337	26	49	target	target	NOUN
dti-1337	26	50	for	for	ADP
dti-1337	26	51	this	this	DET
dti-1337	26	52	strategy	strategy	NOUN
dti-1337	26	53	because	because	SCONJ
dti-1337	26	54	it	it	PRON
dti-1337	26	55	is	be	AUX
dti-1337	26	56	found	find	VERB
dti-1337	26	57	in	in	ADP
dti-1337	26	58	all	all	DET
dti-1337	26	59	tissues,24,26	tissues,24,26	NOUN
dti-1337	26	60	and	and	CCONJ
dti-1337	26	61	is	be	AUX
dti-1337	26	62	preferentially	preferentially	ADV
dti-1337	26	63	expressed	express	VERB
dti-1337	26	64	in	in	ADP
dti-1337	26	65	tumor	tumor	NOUN
dti-1337	26	66	cells.24,26,27	cells.24,26,27	ADP
dti-1337	26	67	in	in	ADP
dti-1337	26	68	addition	addition	NOUN
dti-1337	26	69	,	,	PUNCT
dti-1337	26	70	nqo1	nqo1	PROPN
dti-1337	26	71	levels	level	NOUN
dti-1337	26	72	are	be	AUX
dti-1337	26	73	generally	generally	ADV
dti-1337	26	74	low	low	ADJ
dti-1337	26	75	in	in	ADP
dti-1337	26	76	hematopoetic	hematopoetic	ADJ
dti-1337	26	77	cells.26	cells.26	NOUN
dti-1337	26	78	thus	thus	ADV
dti-1337	26	79	,	,	PUNCT
dti-1337	26	80	agents	agent	NOUN
dti-1337	26	81	,	,	PUNCT
dti-1337	26	82	like	like	ADP
dti-1337	26	83	rh1	rh1	NOUN
dti-1337	26	84	,	,	PUNCT
dti-1337	26	85	that	that	PRON
dti-1337	26	86	are	be	AUX
dti-1337	26	87	selectively	selectively	ADV
dti-1337	26	88	activated	activate	VERB
dti-1337	26	89	by	by	ADP
dti-1337	26	90	nqo1,14	nqo1,14	ADV
dti-1337	26	91	have	have	AUX
dti-1337	26	92	been	be	AUX
dti-1337	26	93	developed	develop	VERB
dti-1337	26	94	to	to	PART
dti-1337	26	95	target	target	VERB
dti-1337	26	96	tumors	tumor	NOUN
dti-1337	26	97	with	with	ADP
dti-1337	26	98	high	high	ADJ
dti-1337	26	99	nqo1	nqo1	NOUN
dti-1337	26	100	levels	level	NOUN
dti-1337	26	101	and	and	CCONJ
dti-1337	26	102	to	to	PART
dti-1337	26	103	avoid	avoid	VERB
dti-1337	26	104	bone	bone	NOUN
dti-1337	26	105	marrow	marrow	NOUN
dti-1337	26	106	toxicity	toxicity	NOUN
dti-1337	26	107	.	.	PUNCT
dti-1337	27	1	current	current	ADJ
dti-1337	27	2	bioreductive	bioreductive	ADJ
dti-1337	27	3	agents	agent	NOUN
dti-1337	27	4	have	have	AUX
dti-1337	27	5	demonstrated	demonstrate	VERB
dti-1337	27	6	the	the	DET
dti-1337	27	7	potential	potential	NOUN
dti-1337	27	8	of	of	ADP
dti-1337	27	9	this	this	DET
dti-1337	27	10	strategy	strategy	NOUN
dti-1337	27	11	for	for	ADP
dti-1337	27	12	improved	improved	ADJ
dti-1337	27	13	cancer	cancer	NOUN
dti-1337	27	14	chemotherapy	chemotherapy	NOUN
dti-1337	27	15	;	;	PUNCT
dti-1337	27	16	however	however	ADV
dti-1337	27	17	,	,	PUNCT
dti-1337	27	18	a	a	DET
dti-1337	27	19	number	number	NOUN
dti-1337	27	20	of	of	ADP
dti-1337	27	21	problems	problem	NOUN
dti-1337	27	22	have	have	AUX
dti-1337	27	23	hindered	hinder	VERB
dti-1337	27	24	the	the	DET
dti-1337	27	25	development	development	NOUN
dti-1337	27	26	of	of	ADP
dti-1337	27	27	new	new	ADJ
dti-1337	27	28	targeted	target	VERB
dti-1337	27	29	anticancer	anticancer	NOUN
dti-1337	27	30	agents	agent	NOUN
dti-1337	27	31	.	.	PUNCT
dti-1337	28	1	to	to	PART
dti-1337	28	2	use	use	VERB
dti-1337	28	3	nqo1	nqo1	NOUN
dti-1337	28	4	as	as	ADP
dti-1337	28	5	a	a	DET
dti-1337	28	6	target	target	NOUN
dti-1337	28	7	for	for	ADP
dti-1337	28	8	enzyme	enzyme	NOUN
dti-1337	28	9	-	-	PUNCT
dti-1337	28	10	directed	direct	VERB
dti-1337	28	11	tumor	tumor	NOUN
dti-1337	28	12	targeting	targeting	NOUN
dti-1337	28	13	requires	require	VERB
dti-1337	28	14	an	an	DET
dti-1337	28	15	agent	agent	NOUN
dti-1337	28	16	specifi	specifi	PROPN
dti-1337	28	17	cally	cally	ADV
dti-1337	28	18	activated	activate	VERB
dti-1337	28	19	by	by	ADP
dti-1337	28	20	nqo1	nqo1	PROPN
dti-1337	28	21	.	.	PUNCT
dti-1337	29	1	if	if	SCONJ
dti-1337	29	2	the	the	DET
dti-1337	29	3	drug	drug	NOUN
dti-1337	29	4	is	be	AUX
dti-1337	29	5	also	also	ADV
dti-1337	29	6	activated	activate	VERB
dti-1337	29	7	by	by	ADP
dti-1337	29	8	p450	p450	PROPN
dti-1337	29	9	red	red	NOUN
dti-1337	29	10	,	,	PUNCT
dti-1337	29	11	which	which	PRON
dti-1337	29	12	is	be	AUX
dti-1337	29	13	found	find	VERB
dti-1337	29	14	at	at	ADP
dti-1337	29	15	appreciable	appreciable	ADJ
dti-1337	29	16	levels	level	NOUN
dti-1337	29	17	in	in	ADP
dti-1337	29	18	hematopoetic	hematopoetic	ADJ
dti-1337	29	19	cells	cell	NOUN
dti-1337	29	20	and	and	CCONJ
dti-1337	29	21	other	other	ADJ
dti-1337	29	22	organs	organ	NOUN
dti-1337	29	23	,	,	PUNCT
dti-1337	29	24	this	this	PRON
dti-1337	29	25	may	may	AUX
dti-1337	29	26	produce	produce	VERB
dti-1337	29	27	toxic	toxic	ADJ
dti-1337	29	28	side	side	NOUN
dti-1337	29	29	effects	effect	NOUN
dti-1337	29	30	as	as	SCONJ
dti-1337	29	31	is	be	AUX
dti-1337	29	32	seen	see	VERB
dti-1337	29	33	with	with	ADP
dti-1337	29	34	mmc.7	mmc.7	PROPN
dti-1337	29	35	however	however	ADV
dti-1337	29	36	,	,	PUNCT
dti-1337	29	37	nqo1	nqo1	PROPN
dti-1337	29	38	levels	level	NOUN
dti-1337	29	39	vary	vary	VERB
dti-1337	29	40	in	in	ADP
dti-1337	29	41	individual	individual	ADJ
dti-1337	29	42	human	human	ADJ
dti-1337	29	43	tumors	tumor	NOUN
dti-1337	29	44	.	.	PUNCT
dti-1337	30	1	thus	thus	ADV
dti-1337	30	2	,	,	PUNCT
dti-1337	30	3	antitumor	antitumor	PROPN
dti-1337	30	4	agents	agent	NOUN
dti-1337	30	5	that	that	PRON
dti-1337	30	6	have	have	VERB
dti-1337	30	7	a	a	DET
dti-1337	30	8	high	high	ADJ
dti-1337	30	9	affi	affi	NOUN
dti-1337	30	10	nity	nity	NOUN
dti-1337	30	11	for	for	ADP
dti-1337	30	12	nqo1	nqo1	NOUN
dti-1337	30	13	may	may	AUX
dti-1337	30	14	be	be	AUX
dti-1337	30	15	activated	activate	VERB
dti-1337	30	16	by	by	ADP
dti-1337	30	17	the	the	DET
dti-1337	30	18	low	low	ADJ
dti-1337	30	19	levels	level	NOUN
dti-1337	30	20	of	of	ADP
dti-1337	30	21	this	this	DET
dti-1337	30	22	enzyme	enzyme	NOUN
dti-1337	30	23	in	in	ADP
dti-1337	30	24	marrow	marrow	NOUN
dti-1337	30	25	cells	cell	NOUN
dti-1337	30	26	resulting	result	VERB
dti-1337	30	27	in	in	ADP
dti-1337	30	28	marrow	marrow	NOUN
dti-1337	30	29	toxicity	toxicity	NOUN
dti-1337	30	30	,	,	PUNCT
dti-1337	30	31	while	while	SCONJ
dti-1337	30	32	agents	agent	NOUN
dti-1337	30	33	that	that	PRON
dti-1337	30	34	have	have	VERB
dti-1337	30	35	a	a	DET
dti-1337	30	36	low	low	ADJ
dti-1337	30	37	affi	affi	NOUN
dti-1337	30	38	nity	nity	NOUN
dti-1337	30	39	for	for	ADP
dti-1337	30	40	nqo1	nqo1	NOUN
dti-1337	30	41	may	may	AUX
dti-1337	30	42	not	not	PART
dti-1337	30	43	be	be	AUX
dti-1337	30	44	fully	fully	ADV
dti-1337	30	45	activated	activate	VERB
dti-1337	30	46	in	in	ADP
dti-1337	30	47	tumors	tumor	NOUN
dti-1337	30	48	with	with	ADP
dti-1337	30	49	lower	low	ADJ
dti-1337	30	50	levels	level	NOUN
dti-1337	30	51	of	of	ADP
dti-1337	30	52	this	this	DET
dti-1337	30	53	enzyme	enzyme	NOUN
dti-1337	30	54	resulting	result	VERB
dti-1337	30	55	in	in	ADP
dti-1337	30	56	a	a	DET
dti-1337	30	57	poor	poor	ADJ
dti-1337	30	58	tumor	tumor	NOUN
dti-1337	30	59	response	response	NOUN
dti-1337	30	60	.	.	PUNCT
dti-1337	31	1	the	the	DET
dti-1337	31	2	former	former	ADJ
dti-1337	31	3	situation	situation	NOUN
dti-1337	31	4	is	be	AUX
dti-1337	31	5	illustrated	illustrate	VERB
dti-1337	31	6	by	by	ADP
dti-1337	31	7	the	the	DET
dti-1337	31	8	observation	observation	NOUN
dti-1337	31	9	that	that	SCONJ
dti-1337	31	10	rh1	rh1	NOUN
dti-1337	31	11	,	,	PUNCT
dti-1337	31	12	which	which	PRON
dti-1337	31	13	is	be	AUX
dti-1337	31	14	highly	highly	ADV
dti-1337	31	15	specific	specific	ADJ
dti-1337	31	16	for	for	ADP
dti-1337	31	17	activation	activation	NOUN
dti-1337	31	18	by	by	ADP
dti-1337	31	19	nqo114	nqo114	PROPN
dti-1337	31	20	but	but	CCONJ
dti-1337	31	21	has	have	VERB
dti-1337	31	22	very	very	ADV
dti-1337	31	23	high	high	ADJ
dti-1337	31	24	affi	affi	NOUN
dti-1337	31	25	nity	nity	NOUN
dti-1337	31	26	for	for	ADP
dti-1337	31	27	this	this	DET
dti-1337	31	28	enzyme,35	enzyme,35	NOUN
dti-1337	31	29	produces	produce	NOUN
dti-1337	31	30	signifi	signifi	NOUN
dti-1337	31	31	ca	can	AUX
dti-1337	31	32	nt	not	PART
dti-1337	31	33	marrow	marrow	VERB
dti-1337	31	34	toxicity.19	toxicity.19	VERB
dti-1337	31	35	an	an	DET
dti-1337	31	36	example	example	NOUN
dti-1337	31	37	of	of	ADP
dti-1337	31	38	the	the	DET
dti-1337	31	39	latter	latter	ADJ
dti-1337	31	40	situation	situation	NOUN
dti-1337	31	41	is	be	AUX
dti-1337	31	42	the	the	DET
dti-1337	31	43	resistance	resistance	NOUN
dti-1337	31	44	to	to	ADP
dti-1337	31	45	mmc	mmc	PRON
dti-1337	31	46	observed	observe	VERB
dti-1337	31	47	in	in	ADP
dti-1337	31	48	tumor	tumor	NOUN
dti-1337	31	49	cells	cell	NOUN
dti-1337	31	50	with	with	ADP
dti-1337	31	51	low	low	ADJ
dti-1337	31	52	levels	level	NOUN
dti-1337	31	53	of	of	ADP
dti-1337	31	54	nqo1.30,36,37	nqo1.30,36,37	PROPN
dti-1337	31	55	bioreductive	bioreductive	ADJ
dti-1337	31	56	agents	agent	NOUN
dti-1337	31	57	need	need	VERB
dti-1337	31	58	a	a	DET
dti-1337	31	59	bioreductive	bioreductive	ADJ
dti-1337	31	60	element	element	NOUN
dti-1337	31	61	that	that	PRON
dti-1337	31	62	is	be	AUX
dti-1337	31	63	reduced	reduce	VERB
dti-1337	31	64	and	and	CCONJ
dti-1337	31	65	a	a	DET
dti-1337	31	66	cytotoxic	cytotoxic	ADJ
dti-1337	31	67	element	element	NOUN
dti-1337	31	68	that	that	PRON
dti-1337	31	69	is	be	AUX
dti-1337	31	70	activated	activate	VERB
dti-1337	31	71	by	by	ADP
dti-1337	31	72	this	this	DET
dti-1337	31	73	reduction	reduction	NOUN
dti-1337	31	74	and	and	CCONJ
dti-1337	31	75	produces	produce	VERB
dti-1337	31	76	the	the	DET
dti-1337	31	77	cytotoxic	cytotoxic	ADJ
dti-1337	31	78	effects	effect	NOUN
dti-1337	31	79	.	.	PUNCT
dti-1337	32	1	current	current	ADJ
dti-1337	32	2	bioreductive	bioreductive	ADJ
dti-1337	32	3	agents	agent	NOUN
dti-1337	32	4	generally	generally	ADV
dti-1337	32	5	use	use	VERB
dti-1337	32	6	quinones	quinone	NOUN
dti-1337	32	7	or	or	CCONJ
dti-1337	32	8	nitrogen	nitrogen	NOUN
dti-1337	32	9	-	-	PUNCT
dti-1337	32	10	oxides	oxide	NOUN
dti-1337	32	11	as	as	ADP
dti-1337	32	12	bioreductive	bioreductive	ADJ
dti-1337	32	13	elements	element	NOUN
dti-1337	32	14	and	and	CCONJ
dti-1337	32	15	alkylating	alkylate	VERB
dti-1337	32	16	groups	group	NOUN
dti-1337	32	17	like	like	ADP
dti-1337	32	18	aziridines	aziridine	NOUN
dti-1337	32	19	or	or	CCONJ
dti-1337	32	20	nitrogen	nitrogen	NOUN
dti-1337	32	21	mustards	mustard	NOUN
dti-1337	32	22	as	as	ADP
dti-1337	32	23	cytotoxic	cytotoxic	ADJ
dti-1337	32	24	elements	element	NOUN
dti-1337	32	25	.	.	PUNCT
dti-1337	33	1	alkylating	alkylate	VERB
dti-1337	33	2	groups	group	NOUN
dti-1337	33	3	bind	bind	VERB
dti-1337	33	4	to	to	ADP
dti-1337	33	5	dna	dna	PROPN
dti-1337	33	6	to	to	PART
dti-1337	33	7	produce	produce	VERB
dti-1337	33	8	dna	dna	NOUN
dti-1337	33	9	crosslinks1,38,39	crosslinks1,38,39	ADP
dti-1337	33	10	leading	lead	VERB
dti-1337	33	11	to	to	ADP
dti-1337	33	12	cell	cell	NOUN
dti-1337	33	13	death	death	NOUN
dti-1337	33	14	by	by	ADP
dti-1337	33	15	apoptosis.40	apoptosis.40	NOUN
dti-1337	33	16	using	use	VERB
dti-1337	33	17	a	a	DET
dti-1337	33	18	series	series	NOUN
dti-1337	33	19	of	of	ADP
dti-1337	33	20	benzoquinone	benzoquinone	NOUN
dti-1337	33	21	mustards	mustard	NOUN
dti-1337	33	22	(	(	PUNCT
dti-1337	33	23	bm	bm	NOUN
dti-1337	33	24	)	)	PUNCT
dti-1337	33	25	analogs	analog	NOUN
dti-1337	33	26	,	,	PUNCT
dti-1337	33	27	we	we	PRON
dti-1337	33	28	found	find	VERB
dti-1337	33	29	that	that	SCONJ
dti-1337	33	30	sterically	sterically	ADV
dti-1337	33	31	bulky	bulky	ADJ
dti-1337	33	32	groups	group	NOUN
dti-1337	33	33	on	on	ADP
dti-1337	33	34	the	the	DET
dti-1337	33	35	benzoquinone	benzoquinone	NOUN
dti-1337	33	36	ring	ring	NOUN
dti-1337	33	37	signifi	signifi	NOUN
dti-1337	33	38	cantly	cantly	ADV
dti-1337	33	39	decreased	decrease	VERB
dti-1337	33	40	the	the	DET
dti-1337	33	41	rate	rate	NOUN
dti-1337	33	42	of	of	ADP
dti-1337	33	43	reduction	reduction	NOUN
dti-1337	33	44	of	of	ADP
dti-1337	33	45	the	the	DET
dti-1337	33	46	bm	bm	PROPN
dti-1337	33	47	analogs	analog	NOUN
dti-1337	33	48	by	by	ADP
dti-1337	33	49	nqo1	nqo1	PROPN
dti-1337	33	50	and	and	CCONJ
dti-1337	33	51	reduced	reduce	VERB
dti-1337	33	52	their	their	PRON
dti-1337	33	53	cytotoxic	cytotoxic	ADJ
dti-1337	33	54	and	and	CCONJ
dti-1337	33	55	dna	dna	NOUN
dti-1337	33	56	crosslinking	crosslinke	VERB
dti-1337	33	57	activities.41,42	activities.41,42	NOUN
dti-1337	33	58	this	this	PRON
dti-1337	33	59	was	be	AUX
dti-1337	33	60	likely	likely	ADJ
dti-1337	33	61	due	due	ADJ
dti-1337	33	62	to	to	PART
dti-1337	33	63	interference	interference	VERB
dti-1337	33	64	by	by	ADP
dti-1337	33	65	the	the	DET
dti-1337	33	66	bulky	bulky	ADJ
dti-1337	33	67	groups	group	NOUN
dti-1337	33	68	with	with	ADP
dti-1337	33	69	the	the	DET
dti-1337	33	70	ability	ability	NOUN
dti-1337	33	71	of	of	ADP
dti-1337	33	72	the	the	DET
dti-1337	33	73	benzoquinone	benzoquinone	NOUN
dti-1337	33	74	to	to	ADP
dti-1337	33	75	fi	fi	PROPN
dti-1337	33	76	t	t	PROPN
dti-1337	33	77	into	into	ADP
dti-1337	33	78	the	the	DET
dti-1337	33	79	active	active	ADJ
dti-1337	33	80	site	site	NOUN
dti-1337	33	81	of	of	ADP
dti-1337	33	82	nqo1	nqo1	PROPN
dti-1337	33	83	.	.	PUNCT
dti-1337	34	1	the	the	DET
dti-1337	34	2	effect	effect	NOUN
dti-1337	34	3	of	of	ADP
dti-1337	34	4	these	these	DET
dti-1337	34	5	bulky	bulky	ADJ
dti-1337	34	6	groups	group	NOUN
dti-1337	34	7	was	be	AUX
dti-1337	34	8	also	also	ADV
dti-1337	34	9	infl	infl	PROPN
dti-1337	34	10	uenced	uence	VERB
dti-1337	34	11	by	by	ADP
dti-1337	34	12	the	the	DET
dti-1337	34	13	position	position	NOUN
dti-1337	34	14	of	of	ADP
dti-1337	34	15	the	the	DET
dti-1337	34	16	group	group	NOUN
dti-1337	34	17	on	on	ADP
dti-1337	34	18	the	the	DET
dti-1337	34	19	benzoquinone	benzoquinone	NOUN
dti-1337	34	20	ring	ring	NOUN
dti-1337	34	21	moiety	moiety	NOUN
dti-1337	34	22	.	.	PUNCT
dti-1337	35	1	thus	thus	ADV
dti-1337	35	2	,	,	PUNCT
dti-1337	35	3	adding	add	VERB
dti-1337	35	4	an	an	DET
dti-1337	35	5	appropriate	appropriate	ADJ
dti-1337	35	6	sterically	sterically	ADV
dti-1337	35	7	bulky	bulky	ADJ
dti-1337	35	8	group	group	NOUN
dti-1337	35	9	to	to	ADP
dti-1337	35	10	the	the	DET
dti-1337	35	11	benzoquinone	benzoquinone	NOUN
dti-1337	35	12	structure	structure	NOUN
dti-1337	35	13	could	could	AUX
dti-1337	35	14	decrease	decrease	VERB
dti-1337	35	15	the	the	DET
dti-1337	35	16	affi	affi	PROPN
dti-1337	35	17	nity	nity	NOUN
dti-1337	35	18	for	for	ADP
dti-1337	35	19	nqo1	nqo1	PROPN
dti-1337	35	20	.	.	PUNCT
dti-1337	36	1	this	this	PRON
dti-1337	36	2	would	would	AUX
dti-1337	36	3	make	make	VERB
dti-1337	36	4	it	it	PRON
dti-1337	36	5	more	more	ADV
dti-1337	36	6	diffi	diffi	ADJ
dti-1337	36	7	cult	cult	NOUN
dti-1337	36	8	to	to	PART
dti-1337	36	9	activate	activate	VERB
dti-1337	36	10	the	the	DET
dti-1337	36	11	new	new	ADJ
dti-1337	36	12	agent	agent	NOUN
dti-1337	36	13	in	in	ADP
dti-1337	36	14	cells	cell	NOUN
dti-1337	36	15	with	with	ADP
dti-1337	36	16	very	very	ADV
dti-1337	36	17	low	low	ADJ
dti-1337	36	18	levels	level	NOUN
dti-1337	36	19	of	of	ADP
dti-1337	36	20	nqo1	nqo1	PROPN
dti-1337	36	21	,	,	PUNCT
dti-1337	36	22	like	like	ADP
dti-1337	36	23	bone	bone	NOUN
dti-1337	36	24	marrow	marrow	NOUN
dti-1337	36	25	cells	cell	NOUN
dti-1337	36	26	,	,	PUNCT
dti-1337	36	27	but	but	CCONJ
dti-1337	36	28	could	could	AUX
dti-1337	36	29	still	still	ADV
dti-1337	36	30	allow	allow	VERB
dti-1337	36	31	activation	activation	NOUN
dti-1337	36	32	in	in	ADP
dti-1337	36	33	tumor	tumor	NOUN
dti-1337	36	34	cells	cell	NOUN
dti-1337	36	35	with	with	ADP
dti-1337	36	36	higher	high	ADJ
dti-1337	36	37	levels	level	NOUN
dti-1337	36	38	of	of	ADP
dti-1337	36	39	this	this	DET
dti-1337	36	40	enzyme	enzyme	NOUN
dti-1337	36	41	.	.	PUNCT
dti-1337	37	1	since	since	SCONJ
dti-1337	37	2	the	the	DET
dti-1337	37	3	level	level	NOUN
dti-1337	37	4	of	of	ADP
dti-1337	37	5	nqo1	nqo1	NOUN
dti-1337	37	6	in	in	ADP
dti-1337	37	7	tumors	tumor	NOUN
dti-1337	37	8	varies	vary	VERB
dti-1337	37	9	in	in	ADP
dti-1337	37	10	different	different	ADJ
dti-1337	37	11	individuals	individual	NOUN
dti-1337	37	12	,	,	PUNCT
dti-1337	37	13	an	an	DET
dti-1337	37	14	anticancer	anticancer	NOUN
dti-1337	37	15	agent	agent	NOUN
dti-1337	37	16	with	with	ADP
dti-1337	37	17	the	the	DET
dti-1337	37	18	minimum	minimum	ADJ
dti-1337	37	19	affi	affi	PROPN
dti-1337	37	20	nity	nity	NOUN
dti-1337	37	21	for	for	SCONJ
dti-1337	37	22	nqo1	nqo1	PROPN
dti-1337	37	23	to	to	PART
dti-1337	37	24	be	be	AUX
dti-1337	37	25	fully	fully	ADV
dti-1337	37	26	activated	activate	VERB
dti-1337	37	27	by	by	ADP
dti-1337	37	28	the	the	DET
dti-1337	37	29	level	level	NOUN
dti-1337	37	30	of	of	ADP
dti-1337	37	31	enzyme	enzyme	NOUN
dti-1337	37	32	in	in	ADP
dti-1337	37	33	the	the	DET
dti-1337	37	34	tumor	tumor	NOUN
dti-1337	37	35	of	of	ADP
dti-1337	37	36	a	a	DET
dti-1337	37	37	patient	patient	NOUN
dti-1337	37	38	would	would	AUX
dti-1337	37	39	provide	provide	VERB
dti-1337	37	40	the	the	DET
dti-1337	37	41	maximum	maximum	ADJ
dti-1337	37	42	antitumor	antitumor	PROPN
dti-1337	37	43	effect	effect	NOUN
dti-1337	37	44	,	,	PUNCT
dti-1337	37	45	while	while	SCONJ
dti-1337	37	46	minimizing	minimize	VERB
dti-1337	37	47	activation	activation	NOUN
dti-1337	37	48	in	in	ADP
dti-1337	37	49	the	the	DET
dti-1337	37	50	marrow	marrow	NOUN
dti-1337	37	51	and	and	CCONJ
dti-1337	37	52	the	the	DET
dti-1337	37	53	resulting	result	VERB
dti-1337	37	54	marrow	marrow	NOUN
dti-1337	37	55	toxicity	toxicity	NOUN
dti-1337	37	56	for	for	ADP
dti-1337	37	57	that	that	DET
dti-1337	37	58	individual	individual	NOUN
dti-1337	37	59	.	.	PUNCT
dti-1337	38	1	this	this	DET
dti-1337	38	2	strategy	strategy	NOUN
dti-1337	38	3	could	could	AUX
dti-1337	38	4	provide	provide	VERB
dti-1337	38	5	an	an	DET
dti-1337	38	6	optimized	optimize	VERB
dti-1337	38	7	therapeutic	therapeutic	ADJ
dti-1337	38	8	index	index	NOUN
dti-1337	38	9	for	for	ADP
dti-1337	38	10	each	each	DET
dti-1337	38	11	patient	patient	NOUN
dti-1337	38	12	.	.	PUNCT
dti-1337	39	1	in	in	ADP
dti-1337	39	2	this	this	DET
dti-1337	39	3	study	study	NOUN
dti-1337	39	4	,	,	PUNCT
dti-1337	39	5	we	we	PRON
dti-1337	39	6	investigated	investigate	VERB
dti-1337	39	7	a	a	DET
dti-1337	39	8	series	series	NOUN
dti-1337	39	9	of	of	ADP
dti-1337	39	10	bm	bm	PROPN
dti-1337	39	11	analogs	analogs	PROPN
dti-1337	39	12	as	as	ADP
dti-1337	39	13	a	a	DET
dti-1337	39	14	model	model	NOUN
dti-1337	39	15	for	for	ADP
dti-1337	39	16	nqo1	nqo1	NOUN
dti-1337	39	17	targeted	target	VERB
dti-1337	39	18	individualized	individualized	ADJ
dti-1337	39	19	cancer	cancer	NOUN
dti-1337	39	20	chemotherapy	chemotherapy	NOUN
dti-1337	39	21	.	.	PUNCT
dti-1337	40	1	we	we	PRON
dti-1337	40	2	compared	compare	VERB
dti-1337	40	3	the	the	DET
dti-1337	40	4	tumor	tumor	NOUN
dti-1337	40	5	cell	cell	NOUN
dti-1337	40	6	growth	growth	NOUN
dti-1337	40	7	inhibitory	inhibitory	ADJ
dti-1337	40	8	activity	activity	NOUN
dti-1337	40	9	of	of	ADP
dti-1337	40	10	bm	bm	PROPN
dti-1337	40	11	analogs	analog	NOUN
dti-1337	40	12	with	with	ADP
dti-1337	40	13	sterically	sterically	ADV
dti-1337	40	14	bulky	bulky	ADJ
dti-1337	40	15	groups	group	NOUN
dti-1337	40	16	of	of	ADP
dti-1337	40	17	different	different	ADJ
dti-1337	40	18	size	size	NOUN
dti-1337	40	19	and	and	CCONJ
dti-1337	40	20	placed	place	VERB
dti-1337	40	21	at	at	ADP
dti-1337	40	22	different	different	ADJ
dti-1337	40	23	positions	position	NOUN
dti-1337	40	24	on	on	ADP
dti-1337	40	25	the	the	DET
dti-1337	40	26	benzoquinone	benzoquinone	NOUN
dti-1337	40	27	ring	ring	NOUN
dti-1337	40	28	,	,	PUNCT
dti-1337	40	29	using	use	VERB
dti-1337	40	30	tumor	tumor	NOUN
dti-1337	40	31	cell	cell	NOUN
dti-1337	40	32	lines	line	NOUN
dti-1337	40	33	with	with	ADP
dti-1337	40	34	different	different	ADJ
dti-1337	40	35	levels	level	NOUN
dti-1337	40	36	of	of	ADP
dti-1337	40	37	nqo1	nqo1	PROPN
dti-1337	40	38	.	.	PUNCT
dti-1337	41	1	we	we	PRON
dti-1337	41	2	demonstrated	demonstrate	VERB
dti-1337	41	3	that	that	SCONJ
dti-1337	41	4	it	it	PRON
dti-1337	41	5	was	be	AUX
dti-1337	41	6	possible	possible	ADJ
dti-1337	41	7	to	to	PART
dti-1337	41	8	design	design	VERB
dti-1337	41	9	bioreductive	bioreductive	ADJ
dti-1337	41	10	agents	agent	NOUN
dti-1337	41	11	with	with	ADP
dti-1337	41	12	the	the	DET
dti-1337	41	13	appropriate	appropriate	ADJ
dti-1337	41	14	nqo1	nqo1	NOUN
dti-1337	41	15	affi	affi	PROPN
dti-1337	41	16	nity	nity	NOUN
dti-1337	41	17	to	to	PART
dti-1337	41	18	target	target	VERB
dti-1337	41	19	tumors	tumor	NOUN
dti-1337	41	20	with	with	ADP
dti-1337	41	21	specifi	specifi	PROPN
dti-1337	41	22	c	c	PROPN
dti-1337	41	23	levels	level	NOUN
dti-1337	41	24	of	of	ADP
dti-1337	41	25	nqo1	nqo1	PROPN
dti-1337	41	26	.	.	PUNCT
dti-1337	42	1	materials	material	NOUN
dti-1337	42	2	and	and	CCONJ
dti-1337	42	3	methods	method	NOUN
dti-1337	42	4	all	all	DET
dti-1337	42	5	media	medium	NOUN
dti-1337	42	6	,	,	PUNCT
dti-1337	42	7	fetal	fetal	ADJ
dti-1337	42	8	bovine	bovine	NOUN
dti-1337	42	9	serum	serum	NOUN
dti-1337	42	10	and	and	CCONJ
dti-1337	42	11	hank	hank	PROPN
dti-1337	42	12	’s	’s	PART
dti-1337	42	13	balanced	balanced	ADJ
dti-1337	42	14	salt	salt	NOUN
dti-1337	42	15	solutions	solution	NOUN
dti-1337	42	16	were	be	AUX
dti-1337	42	17	obtained	obtain	VERB
dti-1337	42	18	from	from	ADP
dti-1337	42	19	invitrogen	invitrogen	PROPN
dti-1337	42	20	(	(	PUNCT
dti-1337	42	21	burlington	burlington	PROPN
dti-1337	42	22	on	on	ADP
dti-1337	42	23	)	)	PUNCT
dti-1337	42	24	.	.	PUNCT
dti-1337	43	1	all	all	DET
dti-1337	43	2	reagents	reagent	NOUN
dti-1337	43	3	for	for	ADP
dti-1337	43	4	the	the	DET
dti-1337	43	5	nqo1	nqo1	NOUN
dti-1337	43	6	activity	activity	NOUN
dti-1337	43	7	and	and	CCONJ
dti-1337	43	8	mtt	mtt	NOUN
dti-1337	43	9	assays	assay	NOUN
dti-1337	43	10	were	be	AUX
dti-1337	43	11	obtained	obtain	VERB
dti-1337	43	12	from	from	ADP
dti-1337	43	13	sigmaaldrich	sigmaaldrich	PROPN
dti-1337	43	14	(	(	PUNCT
dti-1337	43	15	st	st	PROPN
dti-1337	43	16	.	.	PROPN
dti-1337	43	17	louis	louis	PROPN
dti-1337	43	18	,	,	PUNCT
dti-1337	43	19	mo	mo	PROPN
dti-1337	43	20	)	)	PUNCT
dti-1337	43	21	.	.	PUNCT
dti-1337	44	1	the	the	DET
dti-1337	44	2	fadu	fadu	NOUN
dti-1337	44	3	,	,	PUNCT
dti-1337	44	4	hct116	hct116	ADV
dti-1337	44	5	and	and	CCONJ
dti-1337	44	6	3	3	NUM
dti-1337	44	7	a	a	DET
dti-1337	44	8	model	model	NOUN
dti-1337	44	9	for	for	ADP
dti-1337	44	10	nqo1	nqo1	NOUN
dti-1337	44	11	targeted	target	VERB
dti-1337	44	12	individualized	individualized	ADJ
dti-1337	44	13	chemotherapy	chemotherapy	NOUN
dti-1337	44	14	drug	drug	NOUN
dti-1337	44	15	target	target	NOUN
dti-1337	44	16	insights	insight	NOUN
dti-1337	44	17	2009:4	2009:4	NUM
dti-1337	44	18	t47d	t47d	DET
dti-1337	44	19	cell	cell	NOUN
dti-1337	44	20	lines	line	NOUN
dti-1337	44	21	were	be	AUX
dti-1337	44	22	obtained	obtain	VERB
dti-1337	44	23	from	from	ADP
dti-1337	44	24	the	the	DET
dti-1337	44	25	american	american	ADJ
dti-1337	44	26	type	type	NOUN
dti-1337	44	27	culture	culture	NOUN
dti-1337	44	28	collection	collection	NOUN
dti-1337	44	29	(	(	PUNCT
dti-1337	44	30	rockville	rockville	PROPN
dti-1337	44	31	,	,	PUNCT
dti-1337	44	32	md	md	PROPN
dti-1337	44	33	)	)	PUNCT
dti-1337	44	34	.	.	PUNCT
dti-1337	45	1	fadu	fadu	NOUN
dti-1337	45	2	,	,	PUNCT
dti-1337	45	3	human	human	ADJ
dti-1337	45	4	pharynx	pharynx	NOUN
dti-1337	45	5	squamous	squamous	ADJ
dti-1337	45	6	carcinoma	carcinoma	NOUN
dti-1337	45	7	cells	cell	NOUN
dti-1337	45	8	,	,	PUNCT
dti-1337	45	9	hct116	hct116	PROPN
dti-1337	45	10	,	,	PUNCT
dti-1337	45	11	human	human	ADJ
dti-1337	45	12	colon	colon	NOUN
dti-1337	45	13	carcinoma	carcinoma	NOUN
dti-1337	45	14	cells	cell	NOUN
dti-1337	45	15	and	and	CCONJ
dti-1337	45	16	t47d	t47d	PRON
dti-1337	45	17	,	,	PUNCT
dti-1337	45	18	human	human	ADJ
dti-1337	45	19	breast	breast	NOUN
dti-1337	45	20	ductal	ductal	ADJ
dti-1337	45	21	carcinoma	carcinoma	NOUN
dti-1337	45	22	cells	cell	NOUN
dti-1337	45	23	were	be	AUX
dti-1337	45	24	grown	grow	VERB
dti-1337	45	25	in	in	ADP
dti-1337	45	26	dulbecco	dulbecco	NOUN
dti-1337	45	27	’s	’s	PART
dti-1337	45	28	modifi	modifi	PROPN
dti-1337	45	29	ed	ed	PROPN
dti-1337	45	30	eagle	eagle	PROPN
dti-1337	45	31	’s	’s	PART
dti-1337	45	32	medium	medium	ADJ
dti-1337	45	33	:	:	PUNCT
dti-1337	45	34	hams	ham	NOUN
dti-1337	45	35	f12	f12	NOUN
dti-1337	45	36	(	(	PUNCT
dti-1337	45	37	1:1	1:1	NUM
dti-1337	45	38	)	)	PUNCT
dti-1337	45	39	media	medium	NOUN
dti-1337	45	40	with	with	ADP
dti-1337	45	41	10	10	NUM
dti-1337	45	42	%	%	NOUN
dti-1337	45	43	fetal	fetal	ADJ
dti-1337	45	44	bovine	bovine	NOUN
dti-1337	45	45	serum	serum	NOUN
dti-1337	45	46	.	.	PUNCT
dti-1337	46	1	the	the	DET
dti-1337	46	2	syntheses	synthesis	NOUN
dti-1337	46	3	of	of	ADP
dti-1337	46	4	the	the	DET
dti-1337	46	5	bm	bm	PROPN
dti-1337	46	6	analogs	analogs	PROPN
dti-1337	46	7	p	p	PROPN
dti-1337	46	8	-	-	PUNCT
dti-1337	46	9	mebm	mebm	PROPN
dti-1337	46	10	,	,	PUNCT
dti-1337	46	11	m	m	PROPN
dti-1337	46	12	-	-	PUNCT
dti-1337	46	13	mebm	mebm	PROPN
dti-1337	46	14	,	,	PUNCT
dti-1337	46	15	p	p	NOUN
dti-1337	46	16	-	-	PUNCT
dti-1337	46	17	pbm	pbm	NOUN
dti-1337	46	18	and	and	CCONJ
dti-1337	46	19	m	m	NOUN
dti-1337	46	20	-	-	PUNCT
dti-1337	46	21	pbm	pbm	NOUN
dti-1337	46	22	(	(	PUNCT
dti-1337	46	23	fig	fig	NOUN
dti-1337	46	24	.	.	NOUN
dti-1337	46	25	1	1	X
dti-1337	46	26	)	)	PUNCT
dti-1337	46	27	have	have	AUX
dti-1337	46	28	been	be	AUX
dti-1337	46	29	previously	previously	ADV
dti-1337	46	30	reported.41,42	reported.41,42	ADJ
dti-1337	46	31	m	m	PROPN
dti-1337	46	32	-	-	PUNCT
dti-1337	46	33	nprbm	nprbm	PROPN
dti-1337	46	34	was	be	AUX
dti-1337	46	35	synthesized	synthesize	VERB
dti-1337	46	36	as	as	SCONJ
dti-1337	46	37	described	describe	VERB
dti-1337	46	38	below	below	ADV
dti-1337	46	39	.	.	PUNCT
dti-1337	47	1	for	for	ADP
dti-1337	47	2	the	the	DET
dti-1337	47	3	preparation	preparation	NOUN
dti-1337	47	4	of	of	ADP
dti-1337	47	5	the	the	DET
dti-1337	47	6	m	m	PROPN
dti-1337	47	7	-	-	PUNCT
dti-1337	47	8	nprbm	nprbm	PROPN
dti-1337	47	9	precursor	precursor	NOUN
dti-1337	47	10	2	2	NUM
dti-1337	47	11	-	-	PUNCT
dti-1337	47	12	n	n	CCONJ
dti-1337	47	13	-	-	PUNCT
dti-1337	47	14	propylbenzoquinone	propylbenzoquinone	NOUN
dti-1337	47	15	,	,	PUNCT
dti-1337	47	16	benzoquinone	benzoquinone	NOUN
dti-1337	47	17	(	(	PUNCT
dti-1337	47	18	5.184	5.184	NUM
dti-1337	47	19	g	g	NOUN
dti-1337	47	20	,	,	PUNCT
dti-1337	47	21	48.0	48.0	NUM
dti-1337	47	22	mmol	mmol	NOUN
dti-1337	47	23	)	)	PUNCT
dti-1337	47	24	,	,	PUNCT
dti-1337	47	25	butyric	butyric	ADJ
dti-1337	47	26	acid	acid	NOUN
dti-1337	47	27	(	(	PUNCT
dti-1337	47	28	3.524	3.524	NUM
dti-1337	47	29	g	g	NOUN
dti-1337	47	30	,	,	PUNCT
dti-1337	47	31	40.0	40.0	NUM
dti-1337	47	32	mmol	mmol	NOUN
dti-1337	47	33	)	)	PUNCT
dti-1337	47	34	,	,	PUNCT
dti-1337	47	35	and	and	CCONJ
dti-1337	47	36	silver	silver	NOUN
dti-1337	47	37	nitrate	nitrate	NOUN
dti-1337	47	38	(	(	PUNCT
dti-1337	47	39	1.02	1.02	NUM
dti-1337	47	40	g	g	NOUN
dti-1337	47	41	,	,	PUNCT
dti-1337	47	42	6.0	6.0	NUM
dti-1337	47	43	mmol	mmol	NOUN
dti-1337	47	44	)	)	PUNCT
dti-1337	47	45	in	in	ADP
dti-1337	47	46	a	a	DET
dti-1337	47	47	acetonitrile	acetonitrile	ADJ
dti-1337	47	48	-	-	PUNCT
dti-1337	47	49	water	water	NOUN
dti-1337	47	50	mixture	mixture	NOUN
dti-1337	47	51	(	(	PUNCT
dti-1337	47	52	1:1	1:1	NUM
dti-1337	47	53	)	)	PUNCT
dti-1337	47	54	(	(	PUNCT
dti-1337	47	55	200	200	NUM
dti-1337	47	56	ml	ml	NOUN
dti-1337	47	57	)	)	PUNCT
dti-1337	47	58	were	be	AUX
dti-1337	47	59	heated	heat	VERB
dti-1337	47	60	to	to	PART
dti-1337	47	61	refl	refl	VERB
dti-1337	47	62	ux	ux	PROPN
dti-1337	47	63	while	while	SCONJ
dti-1337	47	64	a	a	DET
dti-1337	47	65	solution	solution	NOUN
dti-1337	47	66	of	of	ADP
dti-1337	47	67	1.0	1.0	NUM
dti-1337	47	68	m	m	PROPN
dti-1337	47	69	ammonium	ammonium	NOUN
dti-1337	47	70	persulfate	persulfate	NOUN
dti-1337	47	71	(	(	PUNCT
dti-1337	47	72	48	48	NUM
dti-1337	47	73	ml	ml	NOUN
dti-1337	47	74	)	)	PUNCT
dti-1337	47	75	was	be	AUX
dti-1337	47	76	added	add	VERB
dti-1337	47	77	dropwise	dropwise	NOUN
dti-1337	47	78	over	over	ADP
dti-1337	47	79	1	1	NUM
dti-1337	47	80	h.	h.	NOUN
dti-1337	47	81	after	after	ADP
dti-1337	47	82	an	an	DET
dti-1337	47	83	additional	additional	ADJ
dti-1337	47	84	1.25	1.25	NUM
dti-1337	47	85	h	h	NOUN
dti-1337	47	86	refl	refl	PROPN
dti-1337	47	87	ux	ux	PROPN
dti-1337	47	88	,	,	PUNCT
dti-1337	47	89	the	the	DET
dti-1337	47	90	mixture	mixture	NOUN
dti-1337	47	91	was	be	AUX
dti-1337	47	92	cooled	cool	VERB
dti-1337	47	93	to	to	ADP
dti-1337	47	94	room	room	NOUN
dti-1337	47	95	temperature	temperature	NOUN
dti-1337	47	96	and	and	CCONJ
dti-1337	47	97	solid	solid	ADJ
dti-1337	47	98	sodium	sodium	NOUN
dti-1337	47	99	bicarbonate	bicarbonate	NOUN
dti-1337	47	100	(	(	PUNCT
dti-1337	47	101	3.36	3.36	NUM
dti-1337	47	102	g	g	NOUN
dti-1337	47	103	,	,	PUNCT
dti-1337	47	104	40	40	NUM
dti-1337	47	105	mmol	mmol	NOUN
dti-1337	47	106	)	)	PUNCT
dti-1337	47	107	was	be	AUX
dti-1337	47	108	added	add	VERB
dti-1337	47	109	in	in	ADP
dti-1337	47	110	portions	portion	NOUN
dti-1337	47	111	to	to	PART
dti-1337	47	112	neutralize	neutralize	VERB
dti-1337	47	113	excess	excess	ADJ
dti-1337	47	114	butyric	butyric	ADJ
dti-1337	47	115	acid	acid	NOUN
dti-1337	47	116	.	.	PUNCT
dti-1337	48	1	the	the	DET
dti-1337	48	2	mixture	mixture	NOUN
dti-1337	48	3	was	be	AUX
dti-1337	48	4	extracted	extract	VERB
dti-1337	48	5	with	with	ADP
dti-1337	48	6	ethyl	ethyl	PROPN
dti-1337	48	7	ether	ether	NOUN
dti-1337	48	8	(	(	PUNCT
dti-1337	48	9	3x100	3x100	NUM
dti-1337	48	10	ml	ml	NOUN
dti-1337	48	11	)	)	PUNCT
dti-1337	48	12	and	and	CCONJ
dti-1337	48	13	the	the	DET
dti-1337	48	14	ether	ether	NOUN
dti-1337	48	15	phase	phase	NOUN
dti-1337	48	16	washed	wash	VERB
dti-1337	48	17	with	with	ADP
dti-1337	48	18	0.5	0.5	NUM
dti-1337	48	19	m	m	PROPN
dti-1337	48	20	sodium	sodium	NOUN
dti-1337	48	21	bicarbonate	bicarbonate	NOUN
dti-1337	48	22	,	,	PUNCT
dti-1337	48	23	brine	brine	NOUN
dti-1337	48	24	and	and	CCONJ
dti-1337	48	25	dried	dry	VERB
dti-1337	48	26	over	over	ADP
dti-1337	48	27	anhydrous	anhydrous	ADJ
dti-1337	48	28	sodium	sodium	NOUN
dti-1337	48	29	sulfate	sulfate	NOUN
dti-1337	48	30	.	.	PUNCT
dti-1337	49	1	the	the	DET
dti-1337	49	2	crude	crude	ADJ
dti-1337	49	3	mixture	mixture	NOUN
dti-1337	49	4	was	be	AUX
dti-1337	49	5	concentrated	concentrate	VERB
dti-1337	49	6	and	and	CCONJ
dti-1337	49	7	dissolved	dissolve	VERB
dti-1337	49	8	in	in	ADP
dti-1337	49	9	hexanes	hexane	NOUN
dti-1337	49	10	-	-	PUNCT
dti-1337	49	11	ethyl	ethyl	NOUN
dti-1337	49	12	acetate	acetate	NOUN
dti-1337	49	13	(	(	PUNCT
dti-1337	49	14	7:1	7:1	NUM
dti-1337	49	15	)	)	PUNCT
dti-1337	49	16	(	(	PUNCT
dti-1337	49	17	30	30	NUM
dti-1337	49	18	ml	ml	NOUN
dti-1337	49	19	)	)	PUNCT
dti-1337	49	20	,	,	PUNCT
dti-1337	49	21	and	and	CCONJ
dti-1337	49	22	fi	fi	NOUN
dti-1337	49	23	ltered	ltere	VERB
dti-1337	49	24	through	through	ADP
dti-1337	49	25	a	a	DET
dti-1337	49	26	short	short	ADJ
dti-1337	49	27	column	column	NOUN
dti-1337	49	28	of	of	ADP
dti-1337	49	29	(	(	PUNCT
dti-1337	49	30	50	50	NUM
dti-1337	49	31	g	g	NOUN
dti-1337	49	32	)	)	PUNCT
dti-1337	49	33	silica	silica	NOUN
dti-1337	49	34	gel	gel	NOUN
dti-1337	49	35	.	.	PUNCT
dti-1337	50	1	concentration	concentration	NOUN
dti-1337	50	2	afforded	afford	VERB
dti-1337	50	3	the	the	DET
dti-1337	50	4	crude	crude	ADJ
dti-1337	50	5	product	product	NOUN
dti-1337	50	6	as	as	ADP
dti-1337	50	7	a	a	DET
dti-1337	50	8	yellow	yellow	ADJ
dti-1337	50	9	oil	oil	NOUN
dti-1337	50	10	,	,	PUNCT
dti-1337	50	11	3.51	3.51	NUM
dti-1337	50	12	g.	g.	NOUN
dti-1337	50	13	a	a	DET
dti-1337	50	14	portion	portion	NOUN
dti-1337	50	15	of	of	ADP
dti-1337	50	16	crude	crude	ADJ
dti-1337	50	17	mixture	mixture	NOUN
dti-1337	50	18	(	(	PUNCT
dti-1337	50	19	665	665	NUM
dti-1337	50	20	mg	mg	NOUN
dti-1337	50	21	)	)	PUNCT
dti-1337	50	22	was	be	AUX
dti-1337	50	23	chromatographed	chromatographe	VERB
dti-1337	50	24	on	on	ADP
dti-1337	50	25	silica	silica	NOUN
dti-1337	50	26	using	use	VERB
dti-1337	50	27	hexanes	hexane	NOUN
dti-1337	50	28	-	-	PUNCT
dti-1337	50	29	ethyl	ethyl	NOUN
dti-1337	50	30	acetate	acetate	NOUN
dti-1337	50	31	(	(	PUNCT
dti-1337	50	32	7:1	7:1	NUM
dti-1337	50	33	)	)	PUNCT
dti-1337	50	34	,	,	PUNCT
dti-1337	50	35	affording	afford	VERB
dti-1337	50	36	pure	pure	ADJ
dti-1337	50	37	2	2	NUM
dti-1337	50	38	-	-	PUNCT
dti-1337	50	39	n	n	CCONJ
dti-1337	50	40	-	-	PUNCT
dti-1337	50	41	propylbenzoquinone	propylbenzoquinone	NOUN
dti-1337	50	42	(	(	PUNCT
dti-1337	50	43	229	229	NUM
dti-1337	50	44	mg	mg	NOUN
dti-1337	50	45	)	)	PUNCT
dti-1337	50	46	as	as	ADP
dti-1337	50	47	a	a	DET
dti-1337	50	48	yellow	yellow	ADJ
dti-1337	50	49	semi	semi	NOUN
dti-1337	50	50	-	-	ADJ
dti-1337	50	51	solid	solid	ADJ
dti-1337	50	52	in	in	ADP
dti-1337	50	53	24	24	NUM
dti-1337	50	54	%	%	NOUN
dti-1337	50	55	overall	overall	ADJ
dti-1337	50	56	yield	yield	NOUN
dti-1337	50	57	.	.	PUNCT
dti-1337	51	1	nmr	nmr	NOUN
dti-1337	51	2	(	(	PUNCT
dti-1337	51	3	cdcl3	cdcl3	PROPN
dti-1337	51	4	):	):	PUNCT
dti-1337	51	5	δ	δ	PROPN
dti-1337	51	6	6.69–6.78	6.69–6.78	PROPN
dti-1337	51	7	(	(	PUNCT
dti-1337	51	8	complex	complex	ADJ
dti-1337	51	9	,	,	PUNCT
dti-1337	51	10	2h	2h	NUM
dti-1337	51	11	)	)	PUNCT
dti-1337	51	12	,	,	PUNCT
dti-1337	51	13	6.57	6.57	NUM
dti-1337	51	14	(	(	PUNCT
dti-1337	51	15	m	m	PROPN
dti-1337	51	16	,	,	PUNCT
dti-1337	51	17	1h	1h	NUM
dti-1337	51	18	)	)	PUNCT
dti-1337	51	19	,	,	PUNCT
dti-1337	51	20	2.40	2.40	NUM
dti-1337	51	21	(	(	PUNCT
dti-1337	51	22	t	t	PROPN
dti-1337	51	23	,	,	PUNCT
dti-1337	51	24	2h	2h	NUM
dti-1337	51	25	)	)	PUNCT
dti-1337	51	26	,	,	PUNCT
dti-1337	51	27	1.55	1.55	NUM
dti-1337	51	28	(	(	PUNCT
dti-1337	51	29	sextet	sextet	NOUN
dti-1337	51	30	,	,	PUNCT
dti-1337	51	31	2h	2h	NUM
dti-1337	51	32	)	)	PUNCT
dti-1337	51	33	,	,	PUNCT
dti-1337	51	34	0.98	0.98	NUM
dti-1337	51	35	(	(	PUNCT
dti-1337	51	36	t	t	PROPN
dti-1337	51	37	,	,	PUNCT
dti-1337	51	38	3h	3h	NUM
dti-1337	51	39	)	)	PUNCT
dti-1337	51	40	.	.	PUNCT
dti-1337	52	1	for	for	ADP
dti-1337	52	2	preparation	preparation	NOUN
dti-1337	52	3	of	of	ADP
dti-1337	52	4	m	m	PROPN
dti-1337	52	5	-	-	PUNCT
dti-1337	52	6	nprbm	nprbm	PROPN
dti-1337	52	7	6	6	NUM
dti-1337	52	8	-	-	PUNCT
dti-1337	52	9	n	n	CCONJ
dti-1337	52	10	-	-	PUNCT
dti-1337	52	11	propyl-2[bis(2	propyl-2[bis(2	ADV
dti-1337	52	12	-	-	PUNCT
dti-1337	52	13	chloroethylamino)]-1,4	chloroethylamino)]-1,4	NOUN
dti-1337	52	14	-	-	PUNCT
dti-1337	52	15	benzoquinone	benzoquinone	NOUN
dti-1337	52	16	(	(	PUNCT
dti-1337	52	17	fig	fig	NOUN
dti-1337	52	18	.	.	NOUN
dti-1337	52	19	1	1	NUM
dti-1337	52	20	)	)	PUNCT
dti-1337	52	21	,	,	PUNCT
dti-1337	52	22	potassium	potassium	NOUN
dti-1337	52	23	fl	fl	NOUN
dti-1337	52	24	uoride	uoride	ADJ
dti-1337	52	25	(	(	PUNCT
dti-1337	52	26	0.266	0.266	NUM
dti-1337	52	27	g	g	NOUN
dti-1337	52	28	,	,	PUNCT
dti-1337	52	29	4.58	4.58	NUM
dti-1337	52	30	mmol	mmol	NOUN
dti-1337	52	31	)	)	PUNCT
dti-1337	52	32	was	be	AUX
dti-1337	52	33	added	add	VERB
dti-1337	52	34	at	at	ADP
dti-1337	52	35	room	room	NOUN
dti-1337	52	36	temperature	temperature	NOUN
dti-1337	52	37	to	to	ADP
dti-1337	52	38	a	a	DET
dti-1337	52	39	stirred	stirred	ADJ
dti-1337	52	40	suspension	suspension	NOUN
dti-1337	52	41	of	of	ADP
dti-1337	52	42	2	2	NUM
dti-1337	52	43	-	-	PUNCT
dti-1337	52	44	n	n	CCONJ
dti-1337	52	45	-	-	PUNCT
dti-1337	52	46	propylbenzoquinone	propylbenzoquinone	NOUN
dti-1337	52	47	(	(	PUNCT
dti-1337	52	48	0.229	0.229	NUM
dti-1337	52	49	g	g	NOUN
dti-1337	52	50	,	,	PUNCT
dti-1337	52	51	1.53	1.53	NUM
dti-1337	52	52	mmol	mmol	NOUN
dti-1337	52	53	)	)	PUNCT
dti-1337	52	54	,	,	PUNCT
dti-1337	52	55	bis(2	bis(2	NOUN
dti-1337	52	56	-	-	PUNCT
dti-1337	52	57	chloroethylamine	chloroethylamine	NOUN
dti-1337	52	58	)	)	PUNCT
dti-1337	52	59	hydrochloride	hydrochloride	NOUN
dti-1337	52	60	(	(	PUNCT
dti-1337	52	61	0.817	0.817	NUM
dti-1337	52	62	g	g	NOUN
dti-1337	52	63	,	,	PUNCT
dti-1337	52	64	4.58	4.58	NUM
dti-1337	52	65	mmol	mmol	NOUN
dti-1337	52	66	)	)	PUNCT
dti-1337	52	67	and	and	CCONJ
dti-1337	52	68	cupric	cupric	ADJ
dti-1337	52	69	acetate	acetate	NOUN
dti-1337	52	70	(	(	PUNCT
dti-1337	52	71	0.187	0.187	NUM
dti-1337	52	72	g	g	NOUN
dti-1337	52	73	,	,	PUNCT
dti-1337	52	74	2.29	2.29	NUM
dti-1337	52	75	mmol	mmol	NOUN
dti-1337	52	76	)	)	PUNCT
dti-1337	52	77	in	in	ADP
dti-1337	52	78	95	95	NUM
dti-1337	52	79	%	%	NOUN
dti-1337	52	80	ethanol	ethanol	NOUN
dti-1337	52	81	(	(	PUNCT
dti-1337	52	82	6.0	6.0	NUM
dti-1337	52	83	ml	ml	NOUN
dti-1337	52	84	)	)	PUNCT
dti-1337	52	85	.	.	PUNCT
dti-1337	53	1	the	the	DET
dti-1337	53	2	mixture	mixture	NOUN
dti-1337	53	3	was	be	AUX
dti-1337	53	4	stirred	stir	VERB
dti-1337	53	5	open	open	ADJ
dti-1337	53	6	to	to	ADP
dti-1337	53	7	the	the	DET
dti-1337	53	8	air	air	NOUN
dti-1337	53	9	but	but	CCONJ
dti-1337	53	10	protected	protect	VERB
dti-1337	53	11	from	from	ADP
dti-1337	53	12	light	light	NOUN
dti-1337	53	13	for	for	ADP
dti-1337	53	14	69	69	NUM
dti-1337	53	15	h.	h.	NOUN
dti-1337	53	16	the	the	DET
dti-1337	53	17	mixture	mixture	NOUN
dti-1337	53	18	was	be	AUX
dti-1337	53	19	fi	fi	NOUN
dti-1337	53	20	ltered	ltere	VERB
dti-1337	53	21	with	with	ADP
dti-1337	53	22	suction	suction	NOUN
dti-1337	53	23	through	through	ADP
dti-1337	53	24	a	a	DET
dti-1337	53	25	celite	celite	ADJ
dti-1337	53	26	pad	pad	NOUN
dti-1337	53	27	to	to	PART
dti-1337	53	28	remove	remove	VERB
dti-1337	53	29	copper	copper	NOUN
dti-1337	53	30	salts	salt	NOUN
dti-1337	53	31	and	and	CCONJ
dti-1337	53	32	the	the	DET
dti-1337	53	33	precipitate	precipitate	NOUN
dti-1337	53	34	washed	wash	VERB
dti-1337	53	35	with	with	ADP
dti-1337	53	36	ethyl	ethyl	PROPN
dti-1337	53	37	acetate	acetate	NOUN
dti-1337	53	38	(	(	PUNCT
dti-1337	53	39	2	2	NUM
dti-1337	53	40	×	×	NOUN
dti-1337	53	41	10	10	NUM
dti-1337	53	42	ml	ml	NOUN
dti-1337	53	43	)	)	PUNCT
dti-1337	53	44	.	.	PUNCT
dti-1337	54	1	the	the	DET
dti-1337	54	2	fi	fi	NOUN
dti-1337	54	3	ltrates	ltrate	NOUN
dti-1337	54	4	were	be	AUX
dti-1337	54	5	concentrated	concentrate	VERB
dti-1337	54	6	,	,	PUNCT
dti-1337	54	7	and	and	CCONJ
dti-1337	54	8	the	the	DET
dti-1337	54	9	residue	residue	NOUN
dti-1337	54	10	was	be	AUX
dti-1337	54	11	taken	take	VERB
dti-1337	54	12	up	up	ADP
dti-1337	54	13	in	in	ADP
dti-1337	54	14	ethyl	ethyl	PROPN
dti-1337	54	15	acetate	acetate	NOUN
dti-1337	54	16	(	(	PUNCT
dti-1337	54	17	30	30	NUM
dti-1337	54	18	ml	ml	NOUN
dti-1337	54	19	)	)	PUNCT
dti-1337	54	20	.	.	PUNCT
dti-1337	55	1	the	the	DET
dti-1337	55	2	organic	organic	PROPN
dti-1337	55	3	bm	bm	PROPN
dti-1337	55	4	analog	analog	NOUN
dti-1337	55	5	p	p	PROPN
dti-1337	55	6	-	-	PUNCT
dti-1337	55	7	mebm	mebm	NOUN
dti-1337	55	8	p	p	NOUN
dti-1337	55	9	-	-	PUNCT
dti-1337	55	10	pbm	pbm	NOUN
dti-1337	55	11	m	m	NOUN
dti-1337	55	12	-	-	PUNCT
dti-1337	55	13	pbm	pbm	NOUN
dti-1337	55	14	m	m	NOUN
dti-1337	55	15	-	-	PUNCT
dti-1337	55	16	mebm	mebm	PROPN
dti-1337	55	17	m	m	PROPN
dti-1337	55	18	-	-	PUNCT
dti-1337	55	19	nprbm	nprbm	PROPN
dti-1337	55	20	r1	r1	PROPN
dti-1337	55	21	r1	r1	PROPN
dti-1337	55	22	r2	r2	PROPN
dti-1337	55	23	r2	r2	PROPN
dti-1337	55	24	ch3	ch3	PROPN
dti-1337	55	25	ch3	ch3	PROPN
dti-1337	55	26	ch3ch2ch2	ch3ch2ch2	PROPN
dti-1337	55	27	ch2ch2cl	ch2ch2cl	PROPN
dti-1337	55	28	ch2ch2cl	ch2ch2cl	PROPN
dti-1337	55	29	h	h	PROPN
dti-1337	55	30	h	h	NOUN
dti-1337	55	31	h	h	NOUN
dti-1337	55	32	h	h	NOUN
dti-1337	55	33	h	h	NOUN
dti-1337	55	34	phenyl	phenyl	NOUN
dti-1337	55	35	phenyl	phenyl	NOUN
dti-1337	55	36	n	n	ADP
dti-1337	55	37	o	o	NOUN
dti-1337	55	38	o	o	NOUN
dti-1337	55	39	1	1	NUM
dti-1337	55	40	2	2	NUM
dti-1337	55	41	3	3	NUM
dti-1337	55	42	45	45	NUM
dti-1337	55	43	6	6	NUM
dti-1337	55	44	figure	figure	NOUN
dti-1337	55	45	1	1	NUM
dti-1337	55	46	.	.	PUNCT
dti-1337	55	47	structures	structure	NOUN
dti-1337	55	48	of	of	ADP
dti-1337	55	49	bm	bm	PROPN
dti-1337	55	50	analogs	analog	NOUN
dti-1337	55	51	.	.	PROPN
dti-1337	55	52	4	4	NUM
dti-1337	55	53	begleiter	begleiter	NOUN
dti-1337	55	54	et	et	PROPN
dti-1337	55	55	al	al	PROPN
dti-1337	55	56	drug	drug	PROPN
dti-1337	55	57	target	target	NOUN
dti-1337	55	58	insights	insight	NOUN
dti-1337	55	59	2009:4	2009:4	NUM
dti-1337	55	60	phase	phase	NOUN
dti-1337	55	61	was	be	AUX
dti-1337	55	62	washed	wash	VERB
dti-1337	55	63	with	with	ADP
dti-1337	55	64	0.15	0.15	NUM
dti-1337	55	65	m	m	PROPN
dti-1337	55	66	hcl	hcl	NOUN
dti-1337	55	67	(	(	PUNCT
dti-1337	55	68	15	15	NUM
dti-1337	55	69	ml	ml	NOUN
dti-1337	55	70	)	)	PUNCT
dti-1337	55	71	,	,	PUNCT
dti-1337	55	72	brine	brine	NOUN
dti-1337	55	73	,	,	PUNCT
dti-1337	55	74	and	and	CCONJ
dti-1337	55	75	then	then	ADV
dti-1337	55	76	dried	dry	VERB
dti-1337	55	77	over	over	ADP
dti-1337	55	78	anhydrous	anhydrous	ADJ
dti-1337	55	79	sodium	sodium	NOUN
dti-1337	55	80	sulfate	sulfate	NOUN
dti-1337	55	81	.	.	PUNCT
dti-1337	56	1	concentration	concentration	NOUN
dti-1337	56	2	,	,	PUNCT
dti-1337	56	3	followed	follow	VERB
dti-1337	56	4	by	by	ADP
dti-1337	56	5	silica	silica	NOUN
dti-1337	56	6	chromatography	chromatography	NOUN
dti-1337	56	7	using	use	VERB
dti-1337	56	8	ethyl	ethyl	PROPN
dti-1337	56	9	acetate	acetate	NOUN
dti-1337	56	10	-	-	PUNCT
dti-1337	56	11	hexanes	hexane	NOUN
dti-1337	56	12	(	(	PUNCT
dti-1337	56	13	1:2	1:2	NUM
dti-1337	56	14	)	)	PUNCT
dti-1337	56	15	afforded	afford	VERB
dti-1337	56	16	the	the	DET
dti-1337	56	17	6	6	NUM
dti-1337	56	18	-	-	PUNCT
dti-1337	56	19	npropyl-2-[bis(2	npropyl-2-[bis(2	ADV
dti-1337	56	20	-	-	PUNCT
dti-1337	56	21	chloroethylamino)]-1,4	chloroethylamino)]-1,4	NOUN
dti-1337	56	22	-	-	PUNCT
dti-1337	56	23	benzoquinone	benzoquinone	NOUN
dti-1337	56	24	as	as	ADP
dti-1337	56	25	a	a	DET
dti-1337	56	26	red	red	ADJ
dti-1337	56	27	semi	semi	ADJ
dti-1337	56	28	-	-	ADJ
dti-1337	56	29	solid	solid	ADJ
dti-1337	56	30	,	,	PUNCT
dti-1337	56	31	0.440	0.440	NUM
dti-1337	56	32	g	g	NOUN
dti-1337	56	33	,	,	PUNCT
dti-1337	56	34	10	10	NUM
dti-1337	56	35	%	%	NOUN
dti-1337	56	36	yield	yield	NOUN
dti-1337	56	37	.	.	PUNCT
dti-1337	57	1	1h	1h	NUM
dti-1337	57	2	nmr	nmr	NOUN
dti-1337	57	3	(	(	PUNCT
dti-1337	57	4	cdcl3	cdcl3	PROPN
dti-1337	57	5	):	):	PUNCT
dti-1337	57	6	δ	δ	PROPN
dti-1337	57	7	6.42	6.42	NUM
dti-1337	57	8	(	(	PUNCT
dti-1337	57	9	m	m	PROPN
dti-1337	57	10	,	,	PUNCT
dti-1337	57	11	1h	1h	NUM
dti-1337	57	12	)	)	PUNCT
dti-1337	57	13	,	,	PUNCT
dti-1337	57	14	5.63	5.63	NUM
dti-1337	57	15	(	(	PUNCT
dti-1337	57	16	d	d	PROPN
dti-1337	57	17	,	,	PUNCT
dti-1337	57	18	1h	1h	NUM
dti-1337	57	19	,	,	PUNCT
dti-1337	57	20	j	j	PROPN
dti-1337	57	21	=	=	SYM
dti-1337	57	22	2.4	2.4	NUM
dti-1337	57	23	hz	hz	NOUN
dti-1337	57	24	)	)	PUNCT
dti-1337	57	25	,	,	PUNCT
dti-1337	57	26	3.82–3.78	3.82–3.78	NUM
dti-1337	57	27	(	(	PUNCT
dti-1337	57	28	m	m	PROPN
dti-1337	57	29	,	,	PUNCT
dti-1337	57	30	4h	4h	NOUN
dti-1337	57	31	)	)	PUNCT
dti-1337	57	32	,	,	PUNCT
dti-1337	57	33	3.74–3.69	3.74–3.69	NUM
dti-1337	57	34	(	(	PUNCT
dti-1337	57	35	m	m	PROPN
dti-1337	57	36	,	,	PUNCT
dti-1337	57	37	4h	4h	NOUN
dti-1337	57	38	)	)	PUNCT
dti-1337	57	39	,	,	PUNCT
dti-1337	57	40	2.37	2.37	NUM
dti-1337	57	41	(	(	PUNCT
dti-1337	57	42	t	t	PROPN
dti-1337	57	43	,	,	PUNCT
dti-1337	57	44	2h	2h	NUM
dti-1337	57	45	)	)	PUNCT
dti-1337	57	46	,	,	PUNCT
dti-1337	57	47	1.54	1.54	NUM
dti-1337	57	48	(	(	PUNCT
dti-1337	57	49	sextet	sextet	NOUN
dti-1337	57	50	,	,	PUNCT
dti-1337	57	51	2h	2h	NUM
dti-1337	57	52	)	)	PUNCT
dti-1337	57	53	,	,	PUNCT
dti-1337	57	54	0.97	0.97	NUM
dti-1337	57	55	(	(	PUNCT
dti-1337	57	56	t	t	PROPN
dti-1337	57	57	,	,	PUNCT
dti-1337	57	58	3h	3h	NUM
dti-1337	57	59	)	)	PUNCT
dti-1337	57	60	;	;	PUNCT
dti-1337	57	61	13c	13c	X
dti-1337	57	62	nmr	nmr	NOUN
dti-1337	57	63	(	(	PUNCT
dti-1337	57	64	cdcl3	cdcl3	PROPN
dti-1337	57	65	):	):	PUNCT
dti-1337	57	66	δ	δ	PROPN
dti-1337	57	67	186.0	186.0	NUM
dti-1337	57	68	,	,	PUNCT
dti-1337	57	69	185.6	185.6	NUM
dti-1337	57	70	,	,	PUNCT
dti-1337	57	71	149.0	149.0	NUM
dti-1337	57	72	,	,	PUNCT
dti-1337	57	73	147.5	147.5	NUM
dti-1337	57	74	,	,	PUNCT
dti-1337	57	75	133.0	133.0	NUM
dti-1337	57	76	,	,	PUNCT
dti-1337	57	77	106.0	106.0	NUM
dti-1337	57	78	,	,	PUNCT
dti-1337	57	79	54.8	54.8	NUM
dti-1337	57	80	,	,	PUNCT
dti-1337	57	81	40.4	40.4	NUM
dti-1337	57	82	,	,	PUNCT
dti-1337	57	83	31.2	31.2	NUM
dti-1337	57	84	,	,	PUNCT
dti-1337	57	85	21.1	21.1	NUM
dti-1337	57	86	,	,	PUNCT
dti-1337	57	87	13.8	13.8	NUM
dti-1337	57	88	.	.	PUNCT
dti-1337	58	1	nqo1	nqo1	NOUN
dti-1337	58	2	activity	activity	NOUN
dti-1337	58	3	in	in	ADP
dti-1337	58	4	the	the	DET
dti-1337	58	5	cell	cell	NOUN
dti-1337	58	6	lines	line	NOUN
dti-1337	58	7	was	be	AUX
dti-1337	58	8	determined	determine	VERB
dti-1337	58	9	as	as	SCONJ
dti-1337	58	10	we	we	PRON
dti-1337	58	11	have	have	AUX
dti-1337	58	12	previously	previously	ADV
dti-1337	58	13	described43	described43	VERB
dti-1337	58	14	using	use	VERB
dti-1337	58	15	2	2	NUM
dti-1337	58	16	,	,	PUNCT
dti-1337	58	17	6	6	NUM
dti-1337	58	18	-	-	PUNCT
dti-1337	58	19	dichlorophenolindophenol	dichlorophenolindophenol	NOUN
dti-1337	58	20	(	(	PUNCT
dti-1337	58	21	dcpip	dcpip	NOUN
dti-1337	58	22	)	)	PUNCT
dti-1337	58	23	as	as	ADP
dti-1337	58	24	the	the	DET
dti-1337	58	25	electron	electron	NOUN
dti-1337	58	26	acceptor	acceptor	NOUN
dti-1337	58	27	.	.	PUNCT
dti-1337	59	1	the	the	DET
dti-1337	59	2	statistical	statistical	ADJ
dti-1337	59	3	signifi	signifi	NOUN
dti-1337	59	4	cance	cance	NOUN
dti-1337	59	5	of	of	ADP
dti-1337	59	6	differences	difference	NOUN
dti-1337	59	7	in	in	ADP
dti-1337	59	8	the	the	DET
dti-1337	59	9	mean	mean	ADJ
dti-1337	59	10	values	value	NOUN
dti-1337	59	11	of	of	ADP
dti-1337	59	12	the	the	DET
dti-1337	59	13	nqo1	nqo1	NOUN
dti-1337	59	14	activities	activity	NOUN
dti-1337	59	15	in	in	ADP
dti-1337	59	16	the	the	DET
dti-1337	59	17	three	three	NUM
dti-1337	59	18	cell	cell	NOUN
dti-1337	59	19	lines	line	NOUN
dti-1337	59	20	was	be	AUX
dti-1337	59	21	evaluated	evaluate	VERB
dti-1337	59	22	using	use	VERB
dti-1337	59	23	a	a	DET
dti-1337	59	24	oneway	oneway	ADJ
dti-1337	59	25	analysis	analysis	NOUN
dti-1337	59	26	of	of	ADP
dti-1337	59	27	variance	variance	NOUN
dti-1337	59	28	.	.	PUNCT
dti-1337	60	1	for	for	ADP
dti-1337	60	2	cell	cell	NOUN
dti-1337	60	3	growth	growth	NOUN
dti-1337	60	4	inhibition	inhibition	NOUN
dti-1337	60	5	studies	study	NOUN
dti-1337	60	6	,	,	PUNCT
dti-1337	60	7	bm	bm	PROPN
dti-1337	60	8	analogs	analog	NOUN
dti-1337	60	9	were	be	AUX
dti-1337	60	10	prepared	prepare	VERB
dti-1337	60	11	at	at	ADP
dti-1337	60	12	various	various	ADJ
dti-1337	60	13	concentrations	concentration	NOUN
dti-1337	60	14	in	in	ADP
dti-1337	60	15	dimethylformamide	dimethylformamide	NOUN
dti-1337	60	16	and	and	CCONJ
dti-1337	60	17	were	be	AUX
dti-1337	60	18	added	add	VERB
dti-1337	60	19	to	to	ADP
dti-1337	60	20	cells	cell	NOUN
dti-1337	60	21	in	in	ADP
dti-1337	60	22	media	medium	NOUN
dti-1337	60	23	.	.	PUNCT
dti-1337	61	1	the	the	DET
dti-1337	61	2	fi	fi	NOUN
dti-1337	61	3	nal	nal	ADJ
dti-1337	61	4	concentration	concentration	NOUN
dti-1337	61	5	of	of	ADP
dti-1337	61	6	dimethylformamide	dimethylformamide	NOUN
dti-1337	61	7	in	in	ADP
dti-1337	61	8	the	the	DET
dti-1337	61	9	cells	cell	NOUN
dti-1337	61	10	was	be	AUX
dti-1337	61	11	1	1	NUM
dti-1337	61	12	%	%	NOUN
dti-1337	61	13	.	.	PUNCT
dti-1337	62	1	the	the	DET
dti-1337	62	2	cells	cell	NOUN
dti-1337	62	3	were	be	AUX
dti-1337	62	4	incubated	incubate	VERB
dti-1337	62	5	with	with	ADP
dti-1337	62	6	the	the	DET
dti-1337	62	7	bm	bm	PROPN
dti-1337	62	8	analog	analog	NOUN
dti-1337	62	9	at	at	ADP
dti-1337	62	10	37	37	NUM
dti-1337	62	11	ºc	ºc	NOUN
dti-1337	62	12	for	for	ADP
dti-1337	62	13	1	1	NUM
dti-1337	62	14	h.	h.	NOUN
dti-1337	62	15	the	the	DET
dti-1337	62	16	cells	cell	NOUN
dti-1337	62	17	were	be	AUX
dti-1337	62	18	washed	wash	VERB
dti-1337	62	19	and	and	CCONJ
dti-1337	62	20	incubated	incubate	VERB
dti-1337	62	21	for	for	ADP
dti-1337	62	22	4	4	NUM
dti-1337	62	23	cell	cell	NOUN
dti-1337	62	24	doublings	doubling	NOUN
dti-1337	62	25	at	at	ADP
dti-1337	62	26	37	37	NUM
dti-1337	62	27	°	°	NOUN
dti-1337	62	28	c	c	NOUN
dti-1337	62	29	.	.	PUNCT
dti-1337	63	1	cell	cell	NOUN
dti-1337	63	2	growth	growth	NOUN
dti-1337	63	3	inhibition	inhibition	NOUN
dti-1337	63	4	was	be	AUX
dti-1337	63	5	determined	determine	VERB
dti-1337	63	6	by	by	ADP
dti-1337	63	7	3-(4	3-(4	NUM
dti-1337	63	8	,	,	PUNCT
dti-1337	63	9	5	5	NUM
dti-1337	63	10	-	-	PUNCT
dti-1337	63	11	dimethylthiazo2	dimethylthiazo2	VERB
dti-1337	63	12	-	-	PUNCT
dti-1337	63	13	yl)-2,5	yl)-2,5	NOUN
dti-1337	63	14	-	-	PUNCT
dti-1337	63	15	diphenyltetrazolium	diphenyltetrazolium	NOUN
dti-1337	63	16	bromide	bromide	NOUN
dti-1337	63	17	(	(	PUNCT
dti-1337	63	18	mtt	mtt	NOUN
dti-1337	63	19	)	)	PUNCT
dti-1337	63	20	assay	assay	VERB
dti-1337	63	21	as	as	SCONJ
dti-1337	63	22	we	we	PRON
dti-1337	63	23	have	have	AUX
dti-1337	63	24	previously	previously	ADV
dti-1337	63	25	described.44,45	described.44,45	VERB
dti-1337	63	26	the	the	DET
dti-1337	63	27	results	result	NOUN
dti-1337	63	28	are	be	AUX
dti-1337	63	29	presented	present	VERB
dti-1337	63	30	as	as	ADP
dti-1337	63	31	relative	relative	ADJ
dti-1337	63	32	absorbance	absorbance	NOUN
dti-1337	63	33	compared	compare	VERB
dti-1337	63	34	with	with	ADP
dti-1337	63	35	control	control	NOUN
dti-1337	63	36	vs	vs	ADP
dti-1337	63	37	drug	drug	NOUN
dti-1337	63	38	concentration	concentration	NOUN
dti-1337	63	39	curves	curve	NOUN
dti-1337	63	40	,	,	PUNCT
dti-1337	63	41	and	and	CCONJ
dti-1337	63	42	as	as	ADP
dti-1337	63	43	ic50	ic50	PROPN
dti-1337	63	44	values	value	NOUN
dti-1337	63	45	(	(	PUNCT
dti-1337	63	46	concentration	concentration	NOUN
dti-1337	63	47	of	of	ADP
dti-1337	63	48	drug	drug	NOUN
dti-1337	63	49	reducing	reduce	VERB
dti-1337	63	50	the	the	DET
dti-1337	63	51	relative	relative	ADJ
dti-1337	63	52	absorbance	absorbance	NOUN
dti-1337	63	53	to	to	ADP
dti-1337	63	54	0.5	0.5	NUM
dti-1337	63	55	)	)	PUNCT
dti-1337	63	56	obtained	obtain	VERB
dti-1337	63	57	from	from	ADP
dti-1337	63	58	the	the	DET
dti-1337	63	59	linear	linear	PROPN
dti-1337	63	60	regression	regression	NOUN
dti-1337	63	61	lines	line	NOUN
dti-1337	63	62	of	of	ADP
dti-1337	63	63	the	the	DET
dti-1337	63	64	relative	relative	ADJ
dti-1337	63	65	absorbance	absorbance	NOUN
dti-1337	63	66	vs	vs	ADP
dti-1337	63	67	drug	drug	NOUN
dti-1337	63	68	concentration	concentration	NOUN
dti-1337	63	69	curves	curve	NOUN
dti-1337	63	70	for	for	ADP
dti-1337	63	71	each	each	DET
dti-1337	63	72	bm	bm	PROPN
dti-1337	63	73	analog	analog	PROPN
dti-1337	63	74	.	.	PUNCT
dti-1337	64	1	the	the	DET
dti-1337	64	2	ic50	ic50	PROPN
dti-1337	64	3	values	value	NOUN
dti-1337	64	4	for	for	ADP
dti-1337	64	5	the	the	DET
dti-1337	64	6	5	5	NUM
dti-1337	64	7	bm	bm	PROPN
dti-1337	64	8	analogs	analog	NOUN
dti-1337	64	9	in	in	ADP
dti-1337	64	10	each	each	DET
dti-1337	64	11	cell	cell	NOUN
dti-1337	64	12	line	line	NOUN
dti-1337	64	13	were	be	AUX
dti-1337	64	14	compared	compare	VERB
dti-1337	64	15	by	by	ADP
dti-1337	64	16	one	one	NUM
dti-1337	64	17	way	way	NOUN
dti-1337	64	18	analysis	analysis	NOUN
dti-1337	64	19	of	of	ADP
dti-1337	64	20	variance	variance	NOUN
dti-1337	64	21	with	with	ADP
dti-1337	64	22	student	student	NOUN
dti-1337	64	23	-	-	PUNCT
dti-1337	64	24	newman	newman	NOUN
dti-1337	64	25	-	-	PUNCT
dti-1337	64	26	kuels	kuel	NOUN
dti-1337	64	27	pairwise	pairwise	VERB
dti-1337	64	28	multiple	multiple	ADJ
dti-1337	64	29	comparison	comparison	NOUN
dti-1337	64	30	.	.	PUNCT
dti-1337	65	1	results	result	VERB
dti-1337	65	2	description	description	NOUN
dti-1337	65	3	of	of	ADP
dti-1337	65	4	the	the	DET
dti-1337	65	5	bm	bm	PROPN
dti-1337	65	6	analogs	analogs	PROPN
dti-1337	65	7	and	and	CCONJ
dti-1337	65	8	cell	cell	NOUN
dti-1337	65	9	lines	line	NOUN
dti-1337	65	10	the	the	DET
dti-1337	65	11	synthesis	synthesis	NOUN
dti-1337	65	12	of	of	ADP
dti-1337	65	13	the	the	DET
dti-1337	65	14	benzoquinone	benzoquinone	NOUN
dti-1337	65	15	mustards	mustard	NOUN
dti-1337	65	16	,	,	PUNCT
dti-1337	65	17	p	p	PROPN
dti-1337	65	18	-	-	PUNCT
dti-1337	65	19	mebm	mebm	PROPN
dti-1337	65	20	,	,	PUNCT
dti-1337	65	21	m	m	PROPN
dti-1337	65	22	-	-	PUNCT
dti-1337	65	23	mebm	mebm	PROPN
dti-1337	65	24	,	,	PUNCT
dti-1337	65	25	p	p	NOUN
dti-1337	65	26	-	-	PUNCT
dti-1337	65	27	pbm	pbm	NOUN
dti-1337	65	28	and	and	CCONJ
dti-1337	65	29	m	m	NOUN
dti-1337	65	30	-	-	PUNCT
dti-1337	65	31	pbm	pbm	NOUN
dti-1337	65	32	was	be	AUX
dti-1337	65	33	previously	previously	ADV
dti-1337	65	34	reported.41,42	reported.41,42	ADJ
dti-1337	65	35	here	here	ADV
dti-1337	65	36	we	we	PRON
dti-1337	65	37	report	report	VERB
dti-1337	65	38	the	the	DET
dti-1337	65	39	synthesis	synthesis	NOUN
dti-1337	65	40	of	of	ADP
dti-1337	65	41	a	a	DET
dti-1337	65	42	new	new	ADJ
dti-1337	65	43	bm	bm	PROPN
dti-1337	65	44	analog	analog	PROPN
dti-1337	65	45	,	,	PUNCT
dti-1337	65	46	m	m	PROPN
dti-1337	65	47	-	-	PUNCT
dti-1337	65	48	nprbm	nprbm	PROPN
dti-1337	65	49	(	(	PUNCT
dti-1337	65	50	fig	fig	NOUN
dti-1337	65	51	.	.	PUNCT
dti-1337	65	52	1	1	NUM
dti-1337	65	53	)	)	PUNCT
dti-1337	65	54	.	.	PUNCT
dti-1337	66	1	p	p	X
dti-1337	66	2	-	-	PUNCT
dti-1337	66	3	mebm	mebm	NOUN
dti-1337	66	4	and	and	CCONJ
dti-1337	66	5	p	p	NOUN
dti-1337	66	6	-	-	PUNCT
dti-1337	66	7	pbm	pbm	NOUN
dti-1337	66	8	have	have	VERB
dti-1337	66	9	functional	functional	ADJ
dti-1337	66	10	group	group	NOUN
dti-1337	66	11	substitutions	substitution	NOUN
dti-1337	66	12	at	at	ADP
dti-1337	66	13	the	the	DET
dti-1337	66	14	c5	c5	PROPN
dti-1337	66	15	position	position	NOUN
dti-1337	66	16	of	of	ADP
dti-1337	66	17	the	the	DET
dti-1337	66	18	benzoquinone	benzoquinone	NOUN
dti-1337	66	19	ring	ring	NOUN
dti-1337	66	20	,	,	PUNCT
dti-1337	66	21	while	while	SCONJ
dti-1337	66	22	m	m	NOUN
dti-1337	66	23	-	-	PUNCT
dti-1337	66	24	mebm	mebm	PROPN
dti-1337	66	25	,	,	PUNCT
dti-1337	66	26	m	m	PROPN
dti-1337	66	27	-	-	PUNCT
dti-1337	66	28	nprbm	nprbm	PROPN
dti-1337	66	29	and	and	CCONJ
dti-1337	66	30	m	m	NOUN
dti-1337	66	31	-	-	PUNCT
dti-1337	66	32	pbm	pbm	NOUN
dti-1337	66	33	have	have	VERB
dti-1337	66	34	functional	functional	ADJ
dti-1337	66	35	group	group	NOUN
dti-1337	66	36	substitution	substitution	NOUN
dti-1337	66	37	at	at	ADP
dti-1337	66	38	the	the	DET
dti-1337	66	39	c6	c6	PROPN
dti-1337	66	40	position	position	NOUN
dti-1337	66	41	of	of	ADP
dti-1337	66	42	the	the	DET
dti-1337	66	43	ring	ring	NOUN
dti-1337	66	44	.	.	PUNCT
dti-1337	67	1	the	the	DET
dti-1337	67	2	relative	relative	ADJ
dti-1337	67	3	steric	steric	ADJ
dti-1337	67	4	size	size	NOUN
dti-1337	67	5	of	of	ADP
dti-1337	67	6	the	the	DET
dti-1337	67	7	functional	functional	ADJ
dti-1337	67	8	groups	group	NOUN
dti-1337	67	9	is	be	AUX
dti-1337	67	10	ch3	ch3	PROPN
dti-1337	67	11	�	�	PROPN
dti-1337	67	12	ch3ch2ch2	ch3ch2ch2	NOUN
dti-1337	67	13	�	�	PROPN
dti-1337	67	14	phenyl	phenyl	NOUN
dti-1337	67	15	.	.	PUNCT
dti-1337	68	1	the	the	DET
dti-1337	68	2	tumor	tumor	NOUN
dti-1337	68	3	cell	cell	NOUN
dti-1337	68	4	growth	growth	NOUN
dti-1337	68	5	inhibitory	inhibitory	ADJ
dti-1337	68	6	effects	effect	NOUN
dti-1337	68	7	of	of	ADP
dti-1337	68	8	the	the	DET
dti-1337	68	9	bm	bm	PROPN
dti-1337	68	10	analogs	analog	NOUN
dti-1337	68	11	in	in	ADP
dti-1337	68	12	human	human	ADJ
dti-1337	68	13	cancer	cancer	NOUN
dti-1337	68	14	cells	cell	NOUN
dti-1337	68	15	with	with	ADP
dti-1337	68	16	different	different	ADJ
dti-1337	68	17	levels	level	NOUN
dti-1337	68	18	of	of	ADP
dti-1337	68	19	nqo1	nqo1	PROPN
dti-1337	68	20	were	be	AUX
dti-1337	68	21	studied	study	VERB
dti-1337	68	22	to	to	PART
dti-1337	68	23	determine	determine	VERB
dti-1337	68	24	if	if	SCONJ
dti-1337	68	25	the	the	DET
dti-1337	68	26	size	size	NOUN
dti-1337	68	27	and	and	CCONJ
dti-1337	68	28	position	position	NOUN
dti-1337	68	29	of	of	ADP
dti-1337	68	30	the	the	DET
dti-1337	68	31	functional	functional	ADJ
dti-1337	68	32	groups	group	NOUN
dti-1337	68	33	could	could	AUX
dti-1337	68	34	determine	determine	VERB
dti-1337	68	35	the	the	DET
dti-1337	68	36	level	level	NOUN
dti-1337	68	37	of	of	ADP
dti-1337	68	38	nqo1	nqo1	NOUN
dti-1337	68	39	required	require	VERB
dti-1337	68	40	to	to	PART
dti-1337	68	41	activate	activate	VERB
dti-1337	68	42	the	the	DET
dti-1337	68	43	analogs	analog	NOUN
dti-1337	68	44	.	.	PUNCT
dti-1337	69	1	tumor	tumor	NOUN
dti-1337	69	2	cell	cell	NOUN
dti-1337	69	3	growth	growth	NOUN
dti-1337	69	4	inhibition	inhibition	NOUN
dti-1337	69	5	studies	study	NOUN
dti-1337	69	6	were	be	AUX
dti-1337	69	7	carried	carry	VERB
dti-1337	69	8	out	out	ADP
dti-1337	69	9	in	in	ADP
dti-1337	69	10	fadu	fadu	ADJ
dti-1337	69	11	human	human	ADJ
dti-1337	69	12	pharynx	pharynx	NOUN
dti-1337	69	13	squamous	squamous	ADJ
dti-1337	69	14	carcinoma	carcinoma	NOUN
dti-1337	69	15	cells	cell	NOUN
dti-1337	69	16	,	,	PUNCT
dti-1337	69	17	hct116	hct116	ADV
dti-1337	69	18	human	human	ADJ
dti-1337	69	19	colon	colon	NOUN
dti-1337	69	20	carcinoma	carcinoma	NOUN
dti-1337	69	21	cells	cell	NOUN
dti-1337	69	22	or	or	CCONJ
dti-1337	69	23	t47d	t47d	DET
dti-1337	69	24	human	human	ADJ
dti-1337	69	25	breast	breast	NOUN
dti-1337	69	26	carcinoma	carcinoma	NOUN
dti-1337	69	27	cells	cell	NOUN
dti-1337	69	28	.	.	PUNCT
dti-1337	70	1	the	the	DET
dti-1337	70	2	mean	mean	ADJ
dti-1337	70	3	±	±	NOUN
dti-1337	70	4	standard	standard	NOUN
dti-1337	70	5	error	error	NOUN
dti-1337	70	6	of	of	ADP
dti-1337	70	7	the	the	DET
dti-1337	70	8	mean	mean	ADJ
dti-1337	70	9	(	(	PUNCT
dti-1337	70	10	sem	sem	NOUN
dti-1337	70	11	)	)	PUNCT
dti-1337	70	12	nqo1	nqo1	NOUN
dti-1337	70	13	activity	activity	NOUN
dti-1337	70	14	in	in	ADP
dti-1337	70	15	these	these	DET
dti-1337	70	16	cells	cell	NOUN
dti-1337	70	17	was	be	AUX
dti-1337	70	18	557.6	557.6	NUM
dti-1337	70	19	±	±	NUM
dti-1337	70	20	120.3	120.3	NUM
dti-1337	70	21	,	,	PUNCT
dti-1337	70	22	230.4	230.4	NUM
dti-1337	70	23	±	±	NUM
dti-1337	70	24	31.3	31.3	NUM
dti-1337	70	25	and	and	CCONJ
dti-1337	70	26	39.7	39.7	NUM
dti-1337	70	27	±	±	NUM
dti-1337	70	28	12.1	12.1	NUM
dti-1337	70	29	nmol.min−1.mg	nmol.min−1.mg	NOUN
dti-1337	70	30	protein−1	protein−1	PROPN
dti-1337	70	31	,	,	PUNCT
dti-1337	70	32	respectively	respectively	ADV
dti-1337	70	33	,	,	PUNCT
dti-1337	70	34	and	and	CCONJ
dti-1337	70	35	these	these	DET
dti-1337	70	36	activities	activity	NOUN
dti-1337	70	37	were	be	AUX
dti-1337	70	38	statistically	statistically	ADV
dti-1337	70	39	different	different	ADJ
dti-1337	70	40	(	(	PUNCT
dti-1337	70	41	p	p	X
dti-1337	70	42	�	�	PROPN
dti-1337	70	43	0.02	0.02	NUM
dti-1337	70	44	)	)	PUNCT
dti-1337	70	45	(	(	PUNCT
dti-1337	70	46	fig	fig	NOUN
dti-1337	70	47	.	.	PUNCT
dti-1337	71	1	2	2	NUM
dti-1337	71	2	)	)	PUNCT
dti-1337	71	3	.	.	PUNCT
dti-1337	72	1	tumor	tumor	NOUN
dti-1337	72	2	cell	cell	NOUN
dti-1337	72	3	growth	growth	NOUN
dti-1337	72	4	inhibition	inhibition	NOUN
dti-1337	72	5	by	by	ADP
dti-1337	72	6	bm	bm	PROPN
dti-1337	72	7	analogs	analogs	PROPN
dti-1337	72	8	fadu	fadu	NOUN
dti-1337	72	9	,	,	PUNCT
dti-1337	72	10	hct116	hct116	ADV
dti-1337	72	11	or	or	CCONJ
dti-1337	72	12	t47d	t47d	PRON
dti-1337	72	13	cells	cell	NOUN
dti-1337	72	14	were	be	AUX
dti-1337	72	15	treated	treat	VERB
dti-1337	72	16	with	with	ADP
dti-1337	72	17	various	various	ADJ
dti-1337	72	18	concentrations	concentration	NOUN
dti-1337	72	19	of	of	ADP
dti-1337	72	20	each	each	DET
dti-1337	72	21	bm	bm	PROPN
dti-1337	72	22	analog	analog	NOUN
dti-1337	72	23	for	for	SCONJ
dti-1337	72	24	1	1	NUM
dti-1337	72	25	h	h	NOUN
dti-1337	72	26	and	and	CCONJ
dti-1337	72	27	tumor	tumor	NOUN
dti-1337	72	28	cell	cell	NOUN
dti-1337	72	29	growth	growth	NOUN
dti-1337	72	30	inhibition	inhibition	NOUN
dti-1337	72	31	was	be	AUX
dti-1337	72	32	determined	determine	VERB
dti-1337	72	33	by	by	ADP
dti-1337	72	34	mtt	mtt	PROPN
dti-1337	72	35	assay.44,45	assay.44,45	ADJ
dti-1337	72	36	figure	figure	NOUN
dti-1337	72	37	3	3	NUM
dti-1337	72	38	shows	show	VERB
dti-1337	72	39	the	the	DET
dti-1337	72	40	growth	growth	NOUN
dti-1337	72	41	inhibition	inhibition	VERB
dti-1337	72	42	curves	curve	NOUN
dti-1337	72	43	for	for	ADP
dti-1337	72	44	each	each	PRON
dti-1337	72	45	of	of	ADP
dti-1337	72	46	the	the	DET
dti-1337	72	47	5	5	NUM
dti-1337	72	48	bm	bm	PROPN
dti-1337	72	49	analogs	analog	NOUN
dti-1337	72	50	in	in	ADP
dti-1337	72	51	the	the	DET
dti-1337	72	52	3	3	NUM
dti-1337	72	53	tumor	tumor	NOUN
dti-1337	72	54	cell	cell	NOUN
dti-1337	72	55	lines	line	NOUN
dti-1337	72	56	.	.	PUNCT
dti-1337	73	1	in	in	ADP
dti-1337	73	2	all	all	DET
dti-1337	73	3	three	three	NUM
dti-1337	73	4	cell	cell	NOUN
dti-1337	73	5	lines	line	NOUN
dti-1337	73	6	,	,	PUNCT
dti-1337	73	7	p	p	X
dti-1337	73	8	-	-	PUNCT
dti-1337	73	9	mebm	mebm	PROPN
dti-1337	73	10	had	have	VERB
dti-1337	73	11	the	the	DET
dti-1337	73	12	greatest	great	ADJ
dti-1337	73	13	inhibitory	inhibitory	ADJ
dti-1337	73	14	effect	effect	NOUN
dti-1337	73	15	while	while	SCONJ
dti-1337	73	16	m	m	NOUN
dti-1337	73	17	-	-	PUNCT
dti-1337	73	18	pbm	pbm	NOUN
dti-1337	73	19	cells	cell	NOUN
dti-1337	73	20	fadu	fadu	VERB
dti-1337	73	21	hct116	hct116	ADV
dti-1337	73	22	t47d	t47d	DET
dti-1337	73	23	n	n	NOUN
dti-1337	73	24	q	q	NOUN
dti-1337	73	25	o	o	NOUN
dti-1337	73	26	1	1	NUM
dti-1337	73	27	a	a	DET
dti-1337	73	28	ct	ct	NOUN
dti-1337	73	29	iv	iv	NOUN
dti-1337	73	30	ity	ity	PROPN
dti-1337	73	31	(	(	PUNCT
dti-1337	73	32	n	n	NOUN
dti-1337	73	33	m	m	VERB
dti-1337	73	34	ol	ol	ADJ
dti-1337	73	35	.m	.m	PROPN
dti-1337	73	36	in	in	ADP
dti-1337	73	37	–	–	PUNCT
dti-1337	73	38	1	1	NUM
dti-1337	73	39	.m	.m	NOUN
dti-1337	73	40	g	g	NOUN
dti-1337	74	1	pr	pr	NOUN
dti-1337	74	2	ot	ot	INTJ
dti-1337	74	3	ei	ei	X
dti-1337	74	4	n–1	n–1	PROPN
dti-1337	74	5	)	)	PUNCT
dti-1337	75	1	600	600	NUM
dti-1337	75	2	400	400	NUM
dti-1337	75	3	200	200	NUM
dti-1337	75	4	0	0	NUM
dti-1337	75	5	figure	figure	NOUN
dti-1337	75	6	2	2	NUM
dti-1337	75	7	.	.	PUNCT
dti-1337	75	8	nqo1	nqo1	NOUN
dti-1337	75	9	activity	activity	NOUN
dti-1337	75	10	in	in	ADP
dti-1337	75	11	tumor	tumor	NOUN
dti-1337	75	12	cell	cell	NOUN
dti-1337	75	13	lines	line	NOUN
dti-1337	75	14	.	.	PUNCT
dti-1337	76	1	nqo1	nqo1	NOUN
dti-1337	76	2	activities	activity	NOUN
dti-1337	76	3	in	in	ADP
dti-1337	76	4	fadu	fadu	NOUN
dti-1337	76	5	,	,	PUNCT
dti-1337	76	6	hct116	hct116	ADV
dti-1337	76	7	and	and	CCONJ
dti-1337	76	8	t47d	t47d	DET
dti-1337	76	9	cells	cell	NOUN
dti-1337	76	10	were	be	AUX
dti-1337	76	11	determined	determine	VERB
dti-1337	76	12	as	as	SCONJ
dti-1337	76	13	described.43	described.43	PROPN
dti-1337	76	14	bars	bar	NOUN
dti-1337	76	15	represent	represent	VERB
dti-1337	76	16	the	the	DET
dti-1337	76	17	mean	mean	ADJ
dti-1337	76	18	±	±	NUM
dti-1337	76	19	sem	sem	NOUN
dti-1337	76	20	of	of	ADP
dti-1337	76	21	3	3	NUM
dti-1337	76	22	or	or	CCONJ
dti-1337	76	23	4	4	NUM
dti-1337	76	24	determinations	determination	NOUN
dti-1337	76	25	.	.	PUNCT
dti-1337	77	1	5	5	NUM
dti-1337	77	2	a	a	DET
dti-1337	77	3	model	model	NOUN
dti-1337	77	4	for	for	ADP
dti-1337	77	5	nqo1	nqo1	NOUN
dti-1337	77	6	targeted	target	VERB
dti-1337	77	7	individualized	individualized	ADJ
dti-1337	77	8	chemotherapy	chemotherapy	NOUN
dti-1337	77	9	drug	drug	NOUN
dti-1337	77	10	target	target	NOUN
dti-1337	77	11	insights	insight	NOUN
dti-1337	77	12	2009:4	2009:4	NUM
dti-1337	77	13	had	have	VERB
dti-1337	77	14	the	the	DET
dti-1337	77	15	smallest	small	ADJ
dti-1337	77	16	effect	effect	NOUN
dti-1337	77	17	.	.	PUNCT
dti-1337	78	1	in	in	ADP
dti-1337	78	2	fadu	fadu	ADJ
dti-1337	78	3	cells	cell	NOUN
dti-1337	78	4	,	,	PUNCT
dti-1337	78	5	the	the	DET
dti-1337	78	6	other	other	ADJ
dti-1337	78	7	3	3	NUM
dti-1337	78	8	bm	bm	PROPN
dti-1337	78	9	analogs	analog	NOUN
dti-1337	78	10	produced	produce	VERB
dti-1337	78	11	intermediate	intermediate	ADJ
dti-1337	78	12	effects	effect	NOUN
dti-1337	78	13	.	.	PUNCT
dti-1337	79	1	in	in	ADP
dti-1337	79	2	hct116	hct116	PROPN
dti-1337	79	3	cells	cell	NOUN
dti-1337	79	4	,	,	PUNCT
dti-1337	79	5	m	m	NOUN
dti-1337	79	6	-	-	PUNCT
dti-1337	79	7	mebm	mebm	NOUN
dti-1337	79	8	and	and	CCONJ
dti-1337	79	9	p	p	NOUN
dti-1337	79	10	-	-	PUNCT
dti-1337	79	11	pbm	pbm	NOUN
dti-1337	79	12	continued	continue	VERB
dti-1337	79	13	to	to	PART
dti-1337	79	14	produce	produce	VERB
dti-1337	79	15	an	an	DET
dti-1337	79	16	intermediate	intermediate	ADJ
dti-1337	79	17	inhibitory	inhibitory	ADJ
dti-1337	79	18	effect	effect	NOUN
dti-1337	79	19	;	;	PUNCT
dti-1337	79	20	however	however	ADV
dti-1337	79	21	,	,	PUNCT
dti-1337	79	22	tumor	tumor	NOUN
dti-1337	79	23	cell	cell	NOUN
dti-1337	79	24	growth	growth	NOUN
dti-1337	79	25	inhibition	inhibition	NOUN
dti-1337	79	26	by	by	ADP
dti-1337	79	27	mnprbm	mnprbm	PROPN
dti-1337	79	28	was	be	AUX
dti-1337	79	29	lower	low	ADJ
dti-1337	79	30	and	and	CCONJ
dti-1337	79	31	was	be	AUX
dti-1337	79	32	similar	similar	ADJ
dti-1337	79	33	to	to	ADP
dti-1337	79	34	that	that	PRON
dti-1337	79	35	produced	produce	VERB
dti-1337	79	36	by	by	ADP
dti-1337	79	37	m	m	NOUN
dti-1337	79	38	-	-	PUNCT
dti-1337	79	39	pbm	pbm	NOUN
dti-1337	79	40	.	.	PUNCT
dti-1337	80	1	in	in	ADP
dti-1337	80	2	t47d	t47d	DET
dti-1337	80	3	cells	cell	NOUN
dti-1337	80	4	,	,	PUNCT
dti-1337	80	5	m	m	NOUN
dti-1337	80	6	-	-	PUNCT
dti-1337	80	7	mebm	mebm	PROPN
dti-1337	80	8	again	again	ADV
dti-1337	80	9	produced	produce	VERB
dti-1337	80	10	an	an	DET
dti-1337	80	11	intermediate	intermediate	ADJ
dti-1337	80	12	tumor	tumor	NOUN
dti-1337	80	13	cell	cell	NOUN
dti-1337	80	14	growth	growth	NOUN
dti-1337	80	15	inhibitory	inhibitory	ADJ
dti-1337	80	16	effect	effect	NOUN
dti-1337	80	17	,	,	PUNCT
dti-1337	80	18	while	while	SCONJ
dti-1337	80	19	p	p	NOUN
dti-1337	80	20	-	-	PUNCT
dti-1337	80	21	pbm	pbm	NOUN
dti-1337	80	22	,	,	PUNCT
dti-1337	80	23	m	m	PROPN
dti-1337	80	24	-	-	PUNCT
dti-1337	80	25	nprbm	nprbm	PROPN
dti-1337	80	26	and	and	CCONJ
dti-1337	80	27	m	m	NOUN
dti-1337	80	28	-	-	PUNCT
dti-1337	80	29	pbm	pbm	NOUN
dti-1337	80	30	all	all	PRON
dti-1337	80	31	produced	produce	VERB
dti-1337	80	32	lower	low	ADJ
dti-1337	80	33	but	but	CCONJ
dti-1337	80	34	similar	similar	ADJ
dti-1337	80	35	inhibitory	inhibitory	ADJ
dti-1337	80	36	effects	effect	NOUN
dti-1337	80	37	.	.	PUNCT
dti-1337	81	1	table	table	NOUN
dti-1337	81	2	1	1	NUM
dti-1337	81	3	shows	show	VERB
dti-1337	81	4	the	the	DET
dti-1337	81	5	ic50	ic50	PROPN
dti-1337	81	6	values	value	NOUN
dti-1337	81	7	for	for	ADP
dti-1337	81	8	the	the	DET
dti-1337	81	9	tumor	tumor	NOUN
dti-1337	81	10	cell	cell	NOUN
dti-1337	81	11	growth	growth	NOUN
dti-1337	81	12	inhibitory	inhibitory	ADJ
dti-1337	81	13	effects	effect	NOUN
dti-1337	81	14	of	of	ADP
dti-1337	81	15	the	the	DET
dti-1337	81	16	bm	bm	PROPN
dti-1337	81	17	analogs	analog	NOUN
dti-1337	81	18	in	in	ADP
dti-1337	81	19	fadu	fadu	NOUN
dti-1337	81	20	,	,	PUNCT
dti-1337	81	21	hct116	hct116	ADV
dti-1337	81	22	and	and	CCONJ
dti-1337	81	23	t47d	t47d	DET
dti-1337	81	24	cells	cell	NOUN
dti-1337	81	25	.	.	PUNCT
dti-1337	82	1	there	there	PRON
dti-1337	82	2	were	be	VERB
dti-1337	82	3	differences	difference	NOUN
dti-1337	82	4	in	in	ADP
dti-1337	82	5	the	the	DET
dti-1337	82	6	overall	overall	ADJ
dti-1337	82	7	sensitivity	sensitivity	NOUN
dti-1337	82	8	of	of	ADP
dti-1337	82	9	the	the	DET
dti-1337	82	10	cell	cell	NOUN
dti-1337	82	11	lines	line	NOUN
dti-1337	82	12	to	to	ADP
dti-1337	82	13	the	the	DET
dti-1337	82	14	bm	bm	PROPN
dti-1337	82	15	analogs	analog	NOUN
dti-1337	82	16	;	;	PUNCT
dti-1337	82	17	however	however	ADV
dti-1337	82	18	,	,	PUNCT
dti-1337	82	19	there	there	PRON
dti-1337	82	20	were	be	VERB
dti-1337	82	21	also	also	ADV
dti-1337	82	22	specifi	specifi	PROPN
dti-1337	82	23	c	c	NOUN
dti-1337	82	24	differences	difference	NOUN
dti-1337	82	25	in	in	ADP
dti-1337	82	26	the	the	DET
dti-1337	82	27	sensitivities	sensitivity	NOUN
dti-1337	82	28	of	of	ADP
dti-1337	82	29	the	the	DET
dti-1337	82	30	cell	cell	NOUN
dti-1337	82	31	lines	line	NOUN
dti-1337	82	32	to	to	ADP
dti-1337	82	33	individual	individual	ADJ
dti-1337	82	34	drugs	drug	NOUN
dti-1337	82	35	.	.	PUNCT
dti-1337	83	1	in	in	ADP
dti-1337	83	2	fadu	fadu	ADJ
dti-1337	83	3	cells	cell	NOUN
dti-1337	83	4	,	,	PUNCT
dti-1337	83	5	the	the	DET
dti-1337	83	6	relative	relative	ADJ
dti-1337	83	7	tumor	tumor	NOUN
dti-1337	83	8	cell	cell	NOUN
dti-1337	83	9	growth	growth	NOUN
dti-1337	83	10	inhibitory	inhibitory	ADJ
dti-1337	83	11	effects	effect	NOUN
dti-1337	83	12	of	of	ADP
dti-1337	83	13	the	the	DET
dti-1337	83	14	bm	bm	PROPN
dti-1337	83	15	analogs	analog	NOUN
dti-1337	83	16	were	be	AUX
dti-1337	83	17	:	:	PUNCT
dti-1337	83	18	p	p	X
dti-1337	83	19	-	-	PUNCT
dti-1337	83	20	mebm	mebm	NOUN
dti-1337	83	21	�	�	PROPN
dti-1337	83	22	m	m	PROPN
dti-1337	83	23	-	-	PUNCT
dti-1337	83	24	mebm	mebm	X
dti-1337	83	25	=	=	PUNCT
dti-1337	84	1	p	p	X
dti-1337	84	2	-	-	PUNCT
dti-1337	84	3	pbm	pbm	NOUN
dti-1337	84	4	�	�	PROPN
dti-1337	84	5	m	m	PROPN
dti-1337	84	6	-	-	PUNCT
dti-1337	84	7	nprbm	nprbm	PROPN
dti-1337	84	8	�	�	PROPN
dti-1337	84	9	m	m	NOUN
dti-1337	84	10	-	-	PUNCT
dti-1337	84	11	pbm	pbm	NOUN
dti-1337	84	12	.	.	PUNCT
dti-1337	85	1	in	in	ADP
dti-1337	85	2	hct116	hct116	PROPN
dti-1337	85	3	cells	cell	NOUN
dti-1337	85	4	,	,	PUNCT
dti-1337	85	5	the	the	DET
dti-1337	85	6	relative	relative	ADJ
dti-1337	85	7	inhibitory	inhibitory	ADJ
dti-1337	85	8	effects	effect	NOUN
dti-1337	85	9	were	be	AUX
dti-1337	85	10	:	:	PUNCT
dti-1337	85	11	p	p	X
dti-1337	85	12	-	-	PUNCT
dti-1337	85	13	mebm	mebm	NOUN
dti-1337	85	14	�	�	PROPN
dti-1337	85	15	m	m	PROPN
dti-1337	85	16	-	-	PUNCT
dti-1337	85	17	mebm	mebm	X
dti-1337	85	18	=	=	PUNCT
dti-1337	86	1	p	p	X
dti-1337	86	2	-	-	PUNCT
dti-1337	86	3	pbm	pbm	NOUN
dti-1337	86	4	�	�	PROPN
dti-1337	86	5	m	m	PROPN
dti-1337	86	6	-	-	PROPN
dti-1337	86	7	nprbm	nprbm	PROPN
dti-1337	86	8	=	=	PUNCT
dti-1337	86	9	m	m	NOUN
dti-1337	86	10	-	-	PUNCT
dti-1337	86	11	pbm	pbm	NOUN
dti-1337	86	12	.	.	PUNCT
dti-1337	87	1	while	while	SCONJ
dti-1337	87	2	in	in	ADP
dti-1337	87	3	t47d	t47d	DET
dti-1337	87	4	cells	cell	NOUN
dti-1337	87	5	,	,	PUNCT
dti-1337	87	6	the	the	DET
dti-1337	87	7	relative	relative	ADJ
dti-1337	87	8	inhibitory	inhibitory	ADJ
dti-1337	87	9	effects	effect	NOUN
dti-1337	87	10	were	be	AUX
dti-1337	87	11	:	:	PUNCT
dti-1337	87	12	pmebm	pmebm	PROPN
dti-1337	87	13	�	�	PROPN
dti-1337	87	14	m	m	PROPN
dti-1337	87	15	-	-	PUNCT
dti-1337	87	16	mebm	mebm	NOUN
dti-1337	87	17	�	�	PROPN
dti-1337	87	18	p	p	NOUN
dti-1337	87	19	-	-	PUNCT
dti-1337	87	20	pbm	pbm	NOUN
dti-1337	87	21	=	=	NOUN
dti-1337	87	22	m	m	NOUN
dti-1337	87	23	-	-	PUNCT
dti-1337	87	24	nprbm	nprbm	NOUN
dti-1337	87	25	=	=	NOUN
dti-1337	87	26	mpbm	mpbm	NOUN
dti-1337	87	27	.	.	PUNCT
dti-1337	88	1	the	the	DET
dti-1337	88	2	differences	difference	NOUN
dti-1337	88	3	in	in	ADP
dti-1337	88	4	activities	activity	NOUN
dti-1337	88	5	of	of	ADP
dti-1337	88	6	the	the	DET
dti-1337	88	7	different	different	ADJ
dti-1337	88	8	analogs	analog	NOUN
dti-1337	88	9	in	in	ADP
dti-1337	88	10	each	each	DET
dti-1337	88	11	cell	cell	NOUN
dti-1337	88	12	line	line	NOUN
dti-1337	88	13	were	be	AUX
dti-1337	88	14	statistically	statistically	ADV
dti-1337	88	15	signifi	signifi	ADJ
dti-1337	88	16	ca	can	AUX
dti-1337	88	17	nt	not	PART
dti-1337	88	18	by	by	ADP
dti-1337	88	19	one	one	NUM
dti-1337	88	20	way	way	NOUN
dti-1337	88	21	analysis	analysis	NOUN
dti-1337	88	22	of	of	ADP
dti-1337	88	23	variance	variance	NOUN
dti-1337	88	24	(	(	PUNCT
dti-1337	88	25	p	p	PROPN
dti-1337	88	26	�	�	PROPN
dti-1337	88	27	0.001	0.001	NUM
dti-1337	88	28	)	)	PUNCT
dti-1337	88	29	.	.	PUNCT
dti-1337	89	1	discussion	discussion	NOUN
dti-1337	89	2	we	we	PRON
dti-1337	89	3	have	have	AUX
dti-1337	89	4	previously	previously	ADV
dti-1337	89	5	demonstrated	demonstrate	VERB
dti-1337	89	6	that	that	SCONJ
dti-1337	89	7	functional	functional	ADJ
dti-1337	89	8	groups	group	NOUN
dti-1337	89	9	can	can	AUX
dti-1337	89	10	signifi	signifi	VERB
dti-1337	89	11	cantly	cantly	PROPN
dti-1337	89	12	infl	infl	PROPN
dti-1337	89	13	uence	uence	NOUN
dti-1337	89	14	the	the	DET
dti-1337	89	15	reduction	reduction	NOUN
dti-1337	89	16	and	and	CCONJ
dti-1337	89	17	activation	activation	NOUN
dti-1337	89	18	of	of	ADP
dti-1337	89	19	bm	bm	PROPN
dti-1337	89	20	bioreductive	bioreductive	ADJ
dti-1337	89	21	agents	agent	NOUN
dti-1337	89	22	by	by	ADP
dti-1337	89	23	nqo1.41,42	nqo1.41,42	NOUN
dti-1337	89	24	activation	activation	NOUN
dti-1337	89	25	of	of	ADP
dti-1337	89	26	these	these	DET
dti-1337	89	27	agents	agent	NOUN
dti-1337	89	28	was	be	AUX
dti-1337	89	29	decreased	decrease	VERB
dti-1337	89	30	as	as	SCONJ
dti-1337	89	31	the	the	DET
dti-1337	89	32	steric	steric	ADJ
dti-1337	89	33	size	size	NOUN
dti-1337	89	34	of	of	ADP
dti-1337	89	35	the	the	DET
dti-1337	89	36	functional	functional	ADJ
dti-1337	89	37	group	group	NOUN
dti-1337	89	38	increased	increase	VERB
dti-1337	89	39	,	,	PUNCT
dti-1337	89	40	and	and	CCONJ
dti-1337	89	41	this	this	PRON
dti-1337	89	42	affect	affect	NOUN
dti-1337	89	43	was	be	AUX
dti-1337	89	44	greater	great	ADJ
dti-1337	89	45	when	when	SCONJ
dti-1337	89	46	the	the	DET
dti-1337	89	47	functional	functional	ADJ
dti-1337	89	48	group	group	NOUN
dti-1337	89	49	was	be	AUX
dti-1337	89	50	at	at	ADP
dti-1337	89	51	the	the	DET
dti-1337	89	52	c6	c6	PROPN
dti-1337	89	53	position	position	NOUN
dti-1337	89	54	on	on	ADP
dti-1337	89	55	the	the	DET
dti-1337	89	56	benzoquinone	benzoquinone	NOUN
dti-1337	89	57	ring	ring	NOUN
dti-1337	89	58	compared	compare	VERB
dti-1337	89	59	with	with	ADP
dti-1337	89	60	the	the	DET
dti-1337	89	61	c5	c5	PROPN
dti-1337	89	62	position	position	NOUN
dti-1337	89	63	of	of	ADP
dti-1337	89	64	the	the	DET
dti-1337	89	65	ring	ring	NOUN
dti-1337	89	66	.	.	PUNCT
dti-1337	90	1	we	we	PRON
dti-1337	90	2	made	make	VERB
dti-1337	90	3	use	use	NOUN
dti-1337	90	4	of	of	ADP
dti-1337	90	5	these	these	DET
dti-1337	90	6	fi	fi	NOUN
dti-1337	90	7	ndings	nding	NOUN
dti-1337	90	8	to	to	PART
dti-1337	90	9	design	design	VERB
dti-1337	90	10	a	a	DET
dti-1337	90	11	series	series	NOUN
dti-1337	90	12	of	of	ADP
dti-1337	90	13	bm	bm	PROPN
dti-1337	90	14	analogs	analog	NOUN
dti-1337	90	15	with	with	ADP
dti-1337	90	16	different	different	ADJ
dti-1337	90	17	affi	affi	PROPN
dti-1337	90	18	nities	nitie	NOUN
dti-1337	90	19	for	for	ADP
dti-1337	90	20	activation	activation	NOUN
dti-1337	90	21	by	by	ADP
dti-1337	90	22	nqo1	nqo1	PROPN
dti-1337	90	23	,	,	PUNCT
dti-1337	90	24	as	as	ADP
dti-1337	90	25	a	a	DET
dti-1337	90	26	model	model	NOUN
dti-1337	90	27	for	for	ADP
dti-1337	90	28	developing	develop	VERB
dti-1337	90	29	t47dfadu	t47dfadu	NOUN
dti-1337	90	30	hct116	hct116	ADV
dti-1337	90	31	r	r	PROPN
dti-1337	90	32	el	el	PROPN
dti-1337	90	33	at	at	ADP
dti-1337	90	34	iv	iv	NUM
dti-1337	90	35	e	e	PROPN
dti-1337	90	36	a	a	DET
dti-1337	90	37	bs	bs	NOUN
dti-1337	90	38	or	or	CCONJ
dti-1337	90	39	ba	ba	PROPN
dti-1337	90	40	nc	nc	PROPN
dti-1337	90	41	e	e	PROPN
dti-1337	90	42	p	p	PROPN
dti-1337	90	43	-	-	PUNCT
dti-1337	90	44	mebm	mebm	PROPN
dti-1337	90	45	m	m	PROPN
dti-1337	90	46	-	-	PROPN
dti-1337	90	47	nprbm	nprbm	PROPN
dti-1337	90	48	p	p	NOUN
dti-1337	90	49	-	-	PUNCT
dti-1337	90	50	pbm	pbm	NOUN
dti-1337	90	51	m	m	NOUN
dti-1337	90	52	-	-	PUNCT
dti-1337	90	53	pbm	pbm	NOUN
dti-1337	90	54	m	m	PROPN
dti-1337	90	55	-	-	PUNCT
dti-1337	90	56	mebm	mebm	PROPN
dti-1337	90	57	bm	bm	PROPN
dti-1337	90	58	analog	analog	PROPN
dti-1337	90	59	concentration	concentration	NOUN
dti-1337	90	60	(	(	PUNCT
dti-1337	90	61	μm	μm	NUM
dti-1337	90	62	)	)	PUNCT
dti-1337	90	63	0	0	NUM
dti-1337	90	64	0.1	0.1	NUM
dti-1337	90	65	0.25	0.25	NUM
dti-1337	90	66	0.5	0.5	NUM
dti-1337	90	67	0.75	0.75	NUM
dti-1337	90	68	1	1	NUM
dti-1337	90	69	1	1	NUM
dti-1337	90	70	2	2	NUM
dti-1337	90	71	3	3	NUM
dti-1337	90	72	4	4	NUM
dti-1337	90	73	5	5	NUM
dti-1337	90	74	0	0	NUM
dti-1337	90	75	2	2	NUM
dti-1337	90	76	4	4	NUM
dti-1337	90	77	6	6	NUM
dti-1337	90	78	8	8	NUM
dti-1337	90	79	10	10	NUM
dti-1337	90	80	0.0	0.0	NUM
dti-1337	90	81	0.5	0.5	NUM
dti-1337	90	82	1.0	1.0	NUM
dti-1337	90	83	1.5	1.5	NUM
dti-1337	90	84	2.0	2.0	NUM
dti-1337	90	85	figure	figure	NOUN
dti-1337	90	86	3	3	NUM
dti-1337	90	87	.	.	PUNCT
dti-1337	90	88	cell	cell	NOUN
dti-1337	90	89	growth	growth	NOUN
dti-1337	90	90	inhibition	inhibition	NOUN
dti-1337	90	91	produced	produce	VERB
dti-1337	90	92	by	by	ADP
dti-1337	90	93	bm	bm	PROPN
dti-1337	90	94	analogs	analog	NOUN
dti-1337	90	95	in	in	ADP
dti-1337	90	96	fadu	fadu	NOUN
dti-1337	90	97	,	,	PUNCT
dti-1337	90	98	hct116	hct116	ADV
dti-1337	90	99	and	and	CCONJ
dti-1337	90	100	t47d	t47d	DET
dti-1337	90	101	cells	cell	NOUN
dti-1337	90	102	.	.	PUNCT
dti-1337	91	1	cells	cell	NOUN
dti-1337	91	2	were	be	AUX
dti-1337	91	3	incubated	incubate	VERB
dti-1337	91	4	at	at	ADP
dti-1337	91	5	37	37	NUM
dti-1337	91	6	°	°	NOUN
dti-1337	91	7	c	c	NOUN
dti-1337	91	8	for	for	SCONJ
dti-1337	91	9	1	1	NUM
dti-1337	91	10	h	h	NOUN
dti-1337	91	11	with	with	ADP
dti-1337	91	12	various	various	ADJ
dti-1337	91	13	concentrations	concentration	NOUN
dti-1337	91	14	of	of	ADP
dti-1337	91	15	each	each	DET
dti-1337	91	16	bm	bm	PROPN
dti-1337	91	17	analog	analog	NOUN
dti-1337	91	18	and	and	CCONJ
dti-1337	91	19	cell	cell	NOUN
dti-1337	91	20	growth	growth	NOUN
dti-1337	91	21	inhibition	inhibition	NOUN
dti-1337	91	22	was	be	AUX
dti-1337	91	23	determined	determine	VERB
dti-1337	91	24	by	by	ADP
dti-1337	91	25	mtt	mtt	NOUN
dti-1337	91	26	assay	assay	NOUN
dti-1337	91	27	as	as	SCONJ
dti-1337	91	28	we	we	PRON
dti-1337	91	29	have	have	AUX
dti-1337	91	30	previously	previously	ADV
dti-1337	91	31	described.44,45	described.44,45	VERB
dti-1337	91	32	the	the	DET
dti-1337	91	33	results	result	NOUN
dti-1337	91	34	are	be	AUX
dti-1337	91	35	presented	present	VERB
dti-1337	91	36	as	as	ADP
dti-1337	91	37	relative	relative	ADJ
dti-1337	91	38	absorbance	absorbance	NOUN
dti-1337	91	39	compared	compare	VERB
dti-1337	91	40	with	with	ADP
dti-1337	91	41	control	control	NOUN
dti-1337	91	42	vs.	vs.	ADP
dti-1337	91	43	drug	drug	NOUN
dti-1337	91	44	concentration	concentration	NOUN
dti-1337	91	45	.	.	PUNCT
dti-1337	92	1	points	point	NOUN
dti-1337	92	2	represent	represent	VERB
dti-1337	92	3	the	the	DET
dti-1337	92	4	mean	mean	ADJ
dti-1337	92	5	±	±	NUM
dti-1337	92	6	sem	sem	NOUN
dti-1337	92	7	of	of	ADP
dti-1337	92	8	3	3	NUM
dti-1337	92	9	or	or	CCONJ
dti-1337	92	10	4	4	NUM
dti-1337	92	11	determinations	determination	NOUN
dti-1337	92	12	.	.	PUNCT
dti-1337	93	1	the	the	DET
dti-1337	93	2	lines	line	NOUN
dti-1337	93	3	are	be	AUX
dti-1337	93	4	linear	linear	ADJ
dti-1337	93	5	regression	regression	NOUN
dti-1337	93	6	lines	line	NOUN
dti-1337	93	7	.	.	PUNCT
dti-1337	94	1	6	6	NUM
dti-1337	94	2	begleiter	begleiter	NOUN
dti-1337	94	3	et	et	PROPN
dti-1337	94	4	al	al	PROPN
dti-1337	94	5	drug	drug	PROPN
dti-1337	94	6	target	target	NOUN
dti-1337	94	7	insights	insight	NOUN
dti-1337	94	8	2009:4	2009:4	NUM
dti-1337	94	9	nqo1	nqo1	NOUN
dti-1337	94	10	targeted	target	VERB
dti-1337	94	11	individualized	individualized	ADJ
dti-1337	94	12	cancer	cancer	NOUN
dti-1337	94	13	chemotherapy	chemotherapy	NOUN
dti-1337	94	14	.	.	PUNCT
dti-1337	95	1	the	the	DET
dti-1337	95	2	analogs	analog	NOUN
dti-1337	95	3	p	p	PROPN
dti-1337	95	4	-	-	PUNCT
dti-1337	95	5	mebm	mebm	PROPN
dti-1337	95	6	and	and	CCONJ
dti-1337	95	7	m	m	PROPN
dti-1337	95	8	-	-	PUNCT
dti-1337	95	9	mebm	mebm	PROPN
dti-1337	95	10	have	have	VERB
dti-1337	95	11	small	small	ADJ
dti-1337	95	12	methyl	methyl	NOUN
dti-1337	95	13	functional	functional	ADJ
dti-1337	95	14	groups	group	NOUN
dti-1337	95	15	at	at	ADP
dti-1337	95	16	c5	c5	PROPN
dti-1337	95	17	and	and	CCONJ
dti-1337	95	18	c6	c6	PROPN
dti-1337	95	19	of	of	ADP
dti-1337	95	20	the	the	DET
dti-1337	95	21	benzoquinone	benzoquinone	NOUN
dti-1337	95	22	ring	ring	NOUN
dti-1337	95	23	,	,	PUNCT
dti-1337	95	24	respectively	respectively	ADV
dti-1337	95	25	.	.	PUNCT
dti-1337	96	1	we	we	PRON
dti-1337	96	2	expected	expect	VERB
dti-1337	96	3	these	these	DET
dti-1337	96	4	analogs	analog	NOUN
dti-1337	96	5	to	to	PART
dti-1337	96	6	be	be	AUX
dti-1337	96	7	most	most	ADV
dti-1337	96	8	easily	easily	ADV
dti-1337	96	9	activated	activate	VERB
dti-1337	96	10	by	by	ADP
dti-1337	96	11	nqo1	nqo1	NOUN
dti-1337	96	12	with	with	ADP
dti-1337	96	13	p	p	PROPN
dti-1337	96	14	-	-	PUNCT
dti-1337	96	15	mebm	mebm	NOUN
dti-1337	96	16	being	be	AUX
dti-1337	96	17	activated	activate	VERB
dti-1337	96	18	by	by	ADP
dti-1337	96	19	a	a	DET
dti-1337	96	20	lower	low	ADJ
dti-1337	96	21	level	level	NOUN
dti-1337	96	22	of	of	ADP
dti-1337	96	23	nqo1	nqo1	NOUN
dti-1337	96	24	activity	activity	NOUN
dti-1337	96	25	than	than	ADP
dti-1337	96	26	m	m	NOUN
dti-1337	96	27	-	-	PUNCT
dti-1337	96	28	mebm	mebm	PROPN
dti-1337	96	29	.	.	PUNCT
dti-1337	97	1	the	the	DET
dti-1337	97	2	p	p	NOUN
dti-1337	97	3	-	-	PUNCT
dti-1337	97	4	pbm	pbm	NOUN
dti-1337	97	5	and	and	CCONJ
dti-1337	97	6	m	m	NOUN
dti-1337	97	7	-	-	PUNCT
dti-1337	97	8	pbm	pbm	NOUN
dti-1337	97	9	analogs	analog	NOUN
dti-1337	97	10	have	have	VERB
dti-1337	97	11	larger	large	ADJ
dti-1337	97	12	phenyl	phenyl	NOUN
dti-1337	97	13	functional	functional	ADJ
dti-1337	97	14	groups	group	NOUN
dti-1337	97	15	at	at	ADP
dti-1337	97	16	c5	c5	PROPN
dti-1337	97	17	and	and	CCONJ
dti-1337	97	18	c6	c6	PROPN
dti-1337	97	19	of	of	ADP
dti-1337	97	20	the	the	DET
dti-1337	97	21	ring	ring	NOUN
dti-1337	97	22	,	,	PUNCT
dti-1337	97	23	respectively	respectively	ADV
dti-1337	97	24	.	.	PUNCT
dti-1337	98	1	we	we	PRON
dti-1337	98	2	expected	expect	VERB
dti-1337	98	3	these	these	DET
dti-1337	98	4	analogs	analog	NOUN
dti-1337	98	5	to	to	PART
dti-1337	98	6	be	be	AUX
dti-1337	98	7	less	less	ADV
dti-1337	98	8	easily	easily	ADV
dti-1337	98	9	activated	activate	VERB
dti-1337	98	10	by	by	ADP
dti-1337	98	11	nqo1	nqo1	PROPN
dti-1337	98	12	than	than	ADP
dti-1337	98	13	the	the	DET
dti-1337	98	14	methyl	methyl	NOUN
dti-1337	98	15	analogs	analog	NOUN
dti-1337	98	16	,	,	PUNCT
dti-1337	98	17	with	with	ADP
dti-1337	98	18	m	m	NOUN
dti-1337	98	19	-	-	PUNCT
dti-1337	98	20	pbm	pbm	NOUN
dti-1337	98	21	requiring	require	VERB
dti-1337	98	22	the	the	DET
dti-1337	98	23	highest	high	ADJ
dti-1337	98	24	level	level	NOUN
dti-1337	98	25	of	of	ADP
dti-1337	98	26	nqo1	nqo1	NOUN
dti-1337	98	27	activity	activity	NOUN
dti-1337	98	28	.	.	PUNCT
dti-1337	99	1	the	the	DET
dti-1337	99	2	m	m	PROPN
dti-1337	99	3	-	-	PUNCT
dti-1337	99	4	nprbm	nprbm	PROPN
dti-1337	99	5	analog	analog	NOUN
dti-1337	99	6	has	have	VERB
dti-1337	99	7	an	an	DET
dti-1337	99	8	n	n	CCONJ
dti-1337	99	9	-	-	PUNCT
dti-1337	99	10	propyl	propyl	ADJ
dti-1337	99	11	functional	functional	ADJ
dti-1337	99	12	group	group	NOUN
dti-1337	99	13	at	at	ADP
dti-1337	99	14	c6	c6	PROPN
dti-1337	99	15	of	of	ADP
dti-1337	99	16	the	the	DET
dti-1337	99	17	benzoquinone	benzoquinone	NOUN
dti-1337	99	18	ring	ring	NOUN
dti-1337	99	19	.	.	PUNCT
dti-1337	100	1	this	this	DET
dti-1337	100	2	group	group	NOUN
dti-1337	100	3	is	be	AUX
dti-1337	100	4	smaller	small	ADJ
dti-1337	100	5	than	than	ADP
dti-1337	100	6	the	the	DET
dti-1337	100	7	phenyl	phenyl	NOUN
dti-1337	100	8	group	group	NOUN
dti-1337	100	9	and	and	CCONJ
dti-1337	100	10	should	should	AUX
dti-1337	100	11	produce	produce	VERB
dti-1337	100	12	a	a	DET
dti-1337	100	13	bm	bm	PROPN
dti-1337	100	14	analog	analog	NOUN
dti-1337	100	15	that	that	PRON
dti-1337	100	16	is	be	AUX
dti-1337	100	17	activated	activate	VERB
dti-1337	100	18	by	by	ADP
dti-1337	100	19	intermediate	intermediate	ADJ
dti-1337	100	20	levels	level	NOUN
dti-1337	100	21	of	of	ADP
dti-1337	100	22	nqo1	nqo1	PROPN
dti-1337	100	23	.	.	PUNCT
dti-1337	101	1	human	human	ADJ
dti-1337	101	2	tumor	tumor	NOUN
dti-1337	101	3	cells	cell	NOUN
dti-1337	101	4	have	have	VERB
dti-1337	101	5	varied	varied	ADJ
dti-1337	101	6	levels	level	NOUN
dti-1337	101	7	of	of	ADP
dti-1337	101	8	nqo1	nqo1	NOUN
dti-1337	101	9	activity	activity	NOUN
dti-1337	101	10	ranging	range	VERB
dti-1337	101	11	from	from	ADP
dti-1337	101	12	�	�	PROPN
dti-1337	101	13	10	10	NUM
dti-1337	101	14	nmol	nmol	NOUN
dti-1337	101	15	.	.	PUNCT
dti-1337	102	1	min−1.mg	min−1.mg	VERB
dti-1337	102	2	protein−1	protein−1	PROPN
dti-1337	102	3	to	to	ADP
dti-1337	102	4	�	�	PROPN
dti-1337	102	5	1000	1000	NUM
dti-1337	102	6	nmol	nmol	NOUN
dti-1337	102	7	.	.	PUNCT
dti-1337	103	1	min−1.mg	min−1.mg	PROPN
dti-1337	103	2	protein−1	protein−1	PROPN
dti-1337	103	3	.	.	PUNCT
dti-1337	104	1	in	in	ADP
dti-1337	104	2	contrast	contrast	NOUN
dti-1337	104	3	,	,	PUNCT
dti-1337	104	4	human	human	ADJ
dti-1337	104	5	bone	bone	NOUN
dti-1337	104	6	marrow	marrow	NOUN
dti-1337	104	7	cells	cell	NOUN
dti-1337	104	8	generally	generally	ADV
dti-1337	104	9	have	have	VERB
dti-1337	104	10	a	a	DET
dti-1337	104	11	level	level	NOUN
dti-1337	104	12	of	of	ADP
dti-1337	104	13	nqo1	nqo1	NOUN
dti-1337	104	14	activity	activity	NOUN
dti-1337	104	15	�	�	PROPN
dti-1337	104	16	30	30	NUM
dti-1337	104	17	nmol	nmol	NOUN
dti-1337	104	18	.	.	PUNCT
dti-1337	105	1	min−1.mg	min−1.mg	PROPN
dti-1337	105	2	protein−1	protein−1	PROPN
dti-1337	105	3	.	.	PUNCT
dti-1337	106	1	since	since	SCONJ
dti-1337	106	2	bone	bone	NOUN
dti-1337	106	3	marrow	marrow	NOUN
dti-1337	106	4	toxicity	toxicity	NOUN
dti-1337	106	5	is	be	AUX
dti-1337	106	6	often	often	ADV
dti-1337	106	7	the	the	DET
dti-1337	106	8	dose	dose	NOUN
dti-1337	106	9	limiting	limit	VERB
dti-1337	106	10	toxicity	toxicity	NOUN
dti-1337	106	11	for	for	ADP
dti-1337	106	12	bioreductive	bioreductive	ADJ
dti-1337	106	13	agents	agent	NOUN
dti-1337	106	14	,	,	PUNCT
dti-1337	106	15	an	an	DET
dti-1337	106	16	agent	agent	NOUN
dti-1337	106	17	that	that	PRON
dti-1337	106	18	is	be	AUX
dti-1337	106	19	fully	fully	ADV
dti-1337	106	20	activated	activate	VERB
dti-1337	106	21	by	by	ADP
dti-1337	106	22	the	the	DET
dti-1337	106	23	level	level	NOUN
dti-1337	106	24	of	of	ADP
dti-1337	106	25	nqo1	nqo1	NOUN
dti-1337	106	26	in	in	ADP
dti-1337	106	27	the	the	DET
dti-1337	106	28	tumor	tumor	NOUN
dti-1337	106	29	but	but	CCONJ
dti-1337	106	30	is	be	AUX
dti-1337	106	31	not	not	PART
dti-1337	106	32	activated	activate	VERB
dti-1337	106	33	by	by	ADP
dti-1337	106	34	the	the	DET
dti-1337	106	35	level	level	NOUN
dti-1337	106	36	of	of	ADP
dti-1337	106	37	nqo1	nqo1	NOUN
dti-1337	106	38	in	in	ADP
dti-1337	106	39	bone	bone	NOUN
dti-1337	106	40	marrow	marrow	NOUN
dti-1337	106	41	cells	cell	NOUN
dti-1337	106	42	would	would	AUX
dti-1337	106	43	produce	produce	VERB
dti-1337	106	44	little	little	ADJ
dti-1337	106	45	bone	bone	NOUN
dti-1337	106	46	marrow	marrow	NOUN
dti-1337	106	47	toxicity	toxicity	NOUN
dti-1337	106	48	and	and	CCONJ
dti-1337	106	49	would	would	AUX
dti-1337	106	50	have	have	VERB
dti-1337	106	51	the	the	DET
dti-1337	106	52	highest	high	ADJ
dti-1337	106	53	therapeutic	therapeutic	ADJ
dti-1337	106	54	index	index	NOUN
dti-1337	106	55	.	.	PUNCT
dti-1337	107	1	if	if	SCONJ
dti-1337	107	2	a	a	DET
dti-1337	107	3	series	series	NOUN
dti-1337	107	4	of	of	ADP
dti-1337	107	5	bioreductive	bioreductive	ADJ
dti-1337	107	6	agents	agent	NOUN
dti-1337	107	7	that	that	PRON
dti-1337	107	8	were	be	AUX
dti-1337	107	9	activated	activate	VERB
dti-1337	107	10	by	by	ADP
dti-1337	107	11	different	different	ADJ
dti-1337	107	12	levels	level	NOUN
dti-1337	107	13	of	of	ADP
dti-1337	107	14	nqo1	nqo1	PROPN
dti-1337	107	15	were	be	AUX
dti-1337	107	16	available	available	ADJ
dti-1337	107	17	,	,	PUNCT
dti-1337	107	18	a	a	DET
dti-1337	107	19	patient	patient	NOUN
dti-1337	107	20	could	could	AUX
dti-1337	107	21	be	be	AUX
dti-1337	107	22	treated	treat	VERB
dti-1337	107	23	with	with	ADP
dti-1337	107	24	an	an	DET
dti-1337	107	25	agent	agent	NOUN
dti-1337	107	26	that	that	PRON
dti-1337	107	27	was	be	AUX
dti-1337	107	28	maximally	maximally	ADV
dti-1337	107	29	activated	activate	VERB
dti-1337	107	30	by	by	ADP
dti-1337	107	31	the	the	DET
dti-1337	107	32	level	level	NOUN
dti-1337	107	33	of	of	ADP
dti-1337	107	34	nqo1	nqo1	NOUN
dti-1337	107	35	in	in	ADP
dti-1337	107	36	their	their	PRON
dti-1337	107	37	tumor	tumor	NOUN
dti-1337	107	38	but	but	CCONJ
dti-1337	107	39	minimally	minimally	ADV
dti-1337	107	40	activated	activate	VERB
dti-1337	107	41	by	by	ADP
dti-1337	107	42	the	the	DET
dti-1337	107	43	level	level	NOUN
dti-1337	107	44	of	of	ADP
dti-1337	107	45	nqo1	nqo1	NOUN
dti-1337	107	46	in	in	ADP
dti-1337	107	47	their	their	PRON
dti-1337	107	48	bone	bone	NOUN
dti-1337	107	49	marrow	marrow	NOUN
dti-1337	107	50	.	.	PUNCT
dti-1337	108	1	to	to	PART
dti-1337	108	2	test	test	VERB
dti-1337	108	3	this	this	DET
dti-1337	108	4	hypothesis	hypothesis	NOUN
dti-1337	108	5	,	,	PUNCT
dti-1337	108	6	we	we	PRON
dti-1337	108	7	measured	measure	VERB
dti-1337	108	8	tumor	tumor	NOUN
dti-1337	108	9	cell	cell	NOUN
dti-1337	108	10	growth	growth	NOUN
dti-1337	108	11	inhibition	inhibition	NOUN
dti-1337	108	12	produced	produce	VERB
dti-1337	108	13	by	by	ADP
dti-1337	108	14	the	the	DET
dti-1337	108	15	series	series	NOUN
dti-1337	108	16	of	of	ADP
dti-1337	108	17	bm	bm	PROPN
dti-1337	108	18	analogs	analog	NOUN
dti-1337	108	19	having	have	VERB
dti-1337	108	20	different	different	ADJ
dti-1337	108	21	affi	affi	PROPN
dti-1337	108	22	nities	nitie	NOUN
dti-1337	108	23	for	for	ADP
dti-1337	108	24	activation	activation	NOUN
dti-1337	108	25	by	by	ADP
dti-1337	108	26	nqo1	nqo1	PROPN
dti-1337	108	27	,	,	PUNCT
dti-1337	108	28	in	in	ADP
dti-1337	108	29	human	human	ADJ
dti-1337	108	30	tumor	tumor	NOUN
dti-1337	108	31	cell	cell	NOUN
dti-1337	108	32	lines	line	NOUN
dti-1337	108	33	with	with	ADP
dti-1337	108	34	a	a	DET
dti-1337	108	35	wide	wide	ADJ
dti-1337	108	36	range	range	NOUN
dti-1337	108	37	of	of	ADP
dti-1337	108	38	nqo1	nqo1	NOUN
dti-1337	108	39	activity	activity	NOUN
dti-1337	108	40	.	.	PUNCT
dti-1337	109	1	fadu	fadu	ADJ
dti-1337	109	2	human	human	ADJ
dti-1337	109	3	pharynx	pharynx	NOUN
dti-1337	109	4	squamous	squamous	ADJ
dti-1337	109	5	carcinoma	carcinoma	NOUN
dti-1337	109	6	cells	cell	NOUN
dti-1337	109	7	had	have	VERB
dti-1337	109	8	a	a	DET
dti-1337	109	9	high	high	ADJ
dti-1337	109	10	level	level	NOUN
dti-1337	109	11	of	of	ADP
dti-1337	109	12	nqo1	nqo1	NOUN
dti-1337	109	13	activity	activity	NOUN
dti-1337	109	14	,	,	PUNCT
dti-1337	109	15	557.6	557.6	NUM
dti-1337	109	16	±	±	NUM
dti-1337	109	17	120.3	120.3	NUM
dti-1337	109	18	nmol.min−1.mg	nmol.min−1.mg	NOUN
dti-1337	109	19	protein−1	protein−1	PROPN
dti-1337	109	20	,	,	PUNCT
dti-1337	109	21	while	while	SCONJ
dti-1337	109	22	hct116	hct116	ADV
dti-1337	109	23	human	human	ADJ
dti-1337	109	24	colon	colon	NOUN
dti-1337	109	25	carcinoma	carcinoma	NOUN
dti-1337	109	26	cells	cell	NOUN
dti-1337	109	27	had	have	VERB
dti-1337	109	28	a	a	DET
dti-1337	109	29	level	level	NOUN
dti-1337	109	30	of	of	ADP
dti-1337	109	31	nqo1	nqo1	NOUN
dti-1337	109	32	activity	activity	NOUN
dti-1337	109	33	that	that	PRON
dti-1337	109	34	was	be	AUX
dti-1337	109	35	close	close	ADJ
dti-1337	109	36	to	to	ADP
dti-1337	109	37	the	the	DET
dti-1337	109	38	average	average	NOUN
dti-1337	109	39	for	for	ADP
dti-1337	109	40	human	human	ADJ
dti-1337	109	41	tumors	tumor	NOUN
dti-1337	109	42	,	,	PUNCT
dti-1337	109	43	230.4	230.4	NUM
dti-1337	109	44	±	±	NUM
dti-1337	109	45	31	31	NUM
dti-1337	109	46	nmol.min−1.mg	nmol.min−1.mg	NOUN
dti-1337	109	47	protein−1	protein−1	PROPN
dti-1337	109	48	(	(	PUNCT
dti-1337	109	49	fig	fig	NOUN
dti-1337	109	50	.	.	PUNCT
dti-1337	109	51	2	2	NUM
dti-1337	109	52	)	)	PUNCT
dti-1337	109	53	.	.	PUNCT
dti-1337	110	1	in	in	ADP
dti-1337	110	2	contrast	contrast	NOUN
dti-1337	110	3	,	,	PUNCT
dti-1337	110	4	t47d	t47d	DET
dti-1337	110	5	human	human	ADJ
dti-1337	110	6	breast	breast	NOUN
dti-1337	110	7	carcinoma	carcinoma	NOUN
dti-1337	110	8	cells	cell	NOUN
dti-1337	110	9	had	have	VERB
dti-1337	110	10	a	a	DET
dti-1337	110	11	low	low	ADJ
dti-1337	110	12	level	level	NOUN
dti-1337	110	13	of	of	ADP
dti-1337	110	14	nqo1	nqo1	NOUN
dti-1337	110	15	activity	activity	NOUN
dti-1337	110	16	similar	similar	ADJ
dti-1337	110	17	to	to	ADP
dti-1337	110	18	that	that	PRON
dti-1337	110	19	found	find	VERB
dti-1337	110	20	in	in	ADP
dti-1337	110	21	human	human	ADJ
dti-1337	110	22	bone	bone	NOUN
dti-1337	110	23	marrow	marrow	NOUN
dti-1337	110	24	cells	cell	NOUN
dti-1337	110	25	,	,	PUNCT
dti-1337	110	26	39.7	39.7	NUM
dti-1337	110	27	±	±	NUM
dti-1337	110	28	12.1	12.1	NUM
dti-1337	110	29	nmol.min−1.mg	nmol.min−1.mg	NOUN
dti-1337	110	30	protein−1	protein−1	PROPN
dti-1337	110	31	.	.	PUNCT
dti-1337	111	1	when	when	SCONJ
dti-1337	111	2	we	we	PRON
dti-1337	111	3	compared	compare	VERB
dti-1337	111	4	the	the	DET
dti-1337	111	5	inhibition	inhibition	NOUN
dti-1337	111	6	of	of	ADP
dti-1337	111	7	tumor	tumor	NOUN
dti-1337	111	8	cell	cell	NOUN
dti-1337	111	9	growth	growth	NOUN
dti-1337	111	10	produced	produce	VERB
dti-1337	111	11	by	by	ADP
dti-1337	111	12	the	the	DET
dti-1337	111	13	bm	bm	PROPN
dti-1337	111	14	analogs	analog	NOUN
dti-1337	111	15	in	in	ADP
dti-1337	111	16	the	the	DET
dti-1337	111	17	three	three	NUM
dti-1337	111	18	tumor	tumor	NOUN
dti-1337	111	19	cell	cell	NOUN
dti-1337	111	20	lines	line	NOUN
dti-1337	111	21	we	we	PRON
dti-1337	111	22	observed	observe	VERB
dti-1337	111	23	a	a	DET
dti-1337	111	24	number	number	NOUN
dti-1337	111	25	of	of	ADP
dti-1337	111	26	signifi	signifi	NOUN
dti-1337	111	27	ca	can	AUX
dti-1337	111	28	nt	not	PART
dti-1337	111	29	differences	difference	NOUN
dti-1337	111	30	.	.	PUNCT
dti-1337	112	1	looking	look	VERB
dti-1337	112	2	at	at	ADP
dti-1337	112	3	the	the	DET
dti-1337	112	4	overall	overall	ADJ
dti-1337	112	5	activities	activity	NOUN
dti-1337	112	6	of	of	ADP
dti-1337	112	7	the	the	DET
dti-1337	112	8	bm	bm	PROPN
dti-1337	112	9	analogs	analog	NOUN
dti-1337	112	10	,	,	PUNCT
dti-1337	112	11	the	the	DET
dti-1337	112	12	fadu	fadu	NOUN
dti-1337	112	13	and	and	CCONJ
dti-1337	112	14	hct116	hct116	ADV
dti-1337	112	15	cells	cell	NOUN
dti-1337	112	16	appeared	appear	VERB
dti-1337	112	17	to	to	PART
dti-1337	112	18	have	have	VERB
dti-1337	112	19	similar	similar	ADJ
dti-1337	112	20	sensitivities	sensitivity	NOUN
dti-1337	112	21	to	to	ADP
dti-1337	112	22	the	the	DET
dti-1337	112	23	bm	bm	PROPN
dti-1337	112	24	analogs	analogs	PROPN
dti-1337	112	25	as	as	ADP
dti-1337	112	26	a	a	DET
dti-1337	112	27	group	group	NOUN
dti-1337	112	28	,	,	PUNCT
dti-1337	112	29	with	with	ADP
dti-1337	112	30	ic50	ic50	PROPN
dti-1337	112	31	values	value	NOUN
dti-1337	112	32	ranging	range	VERB
dti-1337	112	33	from	from	ADP
dti-1337	112	34	approximately	approximately	ADV
dti-1337	112	35	0.25	0.25	NUM
dti-1337	112	36	to	to	ADP
dti-1337	112	37	6.00	6.00	NUM
dti-1337	112	38	μm	μm	NOUN
dti-1337	112	39	in	in	ADP
dti-1337	112	40	both	both	DET
dti-1337	112	41	cell	cell	NOUN
dti-1337	112	42	lines	line	NOUN
dti-1337	112	43	.	.	PUNCT
dti-1337	113	1	in	in	ADP
dti-1337	113	2	contrast	contrast	NOUN
dti-1337	113	3	,	,	PUNCT
dti-1337	113	4	the	the	DET
dti-1337	113	5	t47d	t47d	PROPN
dti-1337	113	6	cells	cell	NOUN
dti-1337	113	7	appeared	appear	VERB
dti-1337	113	8	to	to	PART
dti-1337	113	9	be	be	AUX
dti-1337	113	10	overall	overall	ADJ
dti-1337	113	11	approximately	approximately	ADV
dti-1337	113	12	5	5	NUM
dti-1337	113	13	-	-	NUM
dti-1337	113	14	fold	fold	VERB
dti-1337	113	15	more	more	ADV
dti-1337	113	16	sensitive	sensitive	ADJ
dti-1337	113	17	to	to	ADP
dti-1337	113	18	these	these	DET
dti-1337	113	19	agents	agent	NOUN
dti-1337	113	20	as	as	ADP
dti-1337	113	21	a	a	DET
dti-1337	113	22	group	group	NOUN
dti-1337	113	23	(	(	PUNCT
dti-1337	113	24	fig	fig	NOUN
dti-1337	113	25	.	.	PUNCT
dti-1337	114	1	3	3	NUM
dti-1337	114	2	,	,	PUNCT
dti-1337	114	3	table	table	NOUN
dti-1337	114	4	1	1	NUM
dti-1337	114	5	)	)	PUNCT
dti-1337	114	6	.	.	PUNCT
dti-1337	115	1	these	these	DET
dti-1337	115	2	differences	difference	NOUN
dti-1337	115	3	likely	likely	ADV
dti-1337	115	4	refl	refl	VERB
dti-1337	115	5	ect	ect	PRON
dti-1337	115	6	general	general	ADJ
dti-1337	115	7	tissue	tissue	NOUN
dti-1337	115	8	type	type	NOUN
dti-1337	115	9	and/or	and/or	CCONJ
dti-1337	115	10	cell	cell	NOUN
dti-1337	115	11	line	line	NOUN
dti-1337	115	12	variations	variation	NOUN
dti-1337	115	13	in	in	ADP
dti-1337	115	14	sensitivity	sensitivity	NOUN
dti-1337	115	15	to	to	ADP
dti-1337	115	16	these	these	DET
dti-1337	115	17	agents	agent	NOUN
dti-1337	115	18	due	due	ADP
dti-1337	115	19	to	to	ADP
dti-1337	115	20	differences	difference	NOUN
dti-1337	115	21	in	in	ADP
dti-1337	115	22	drug	drug	NOUN
dti-1337	115	23	uptake	uptake	NOUN
dti-1337	115	24	,	,	PUNCT
dti-1337	115	25	drug	drug	NOUN
dti-1337	115	26	detoxifi	detoxifi	NOUN
dti-1337	115	27	cation	cation	NOUN
dti-1337	115	28	,	,	PUNCT
dti-1337	115	29	dna	dna	PROPN
dti-1337	115	30	repair	repair	NOUN
dti-1337	115	31	,	,	PUNCT
dti-1337	115	32	induction	induction	NOUN
dti-1337	115	33	of	of	ADP
dti-1337	115	34	apoptosis	apoptosis	NOUN
dti-1337	115	35	and	and	CCONJ
dti-1337	115	36	activation	activation	NOUN
dti-1337	115	37	by	by	ADP
dti-1337	115	38	other	other	ADJ
dti-1337	115	39	enzymes	enzyme	NOUN
dti-1337	115	40	,	,	PUNCT
dti-1337	115	41	and	and	CCONJ
dti-1337	115	42	are	be	AUX
dti-1337	115	43	probably	probably	ADV
dti-1337	115	44	not	not	PART
dti-1337	115	45	related	relate	VERB
dti-1337	115	46	to	to	ADP
dti-1337	115	47	activation	activation	NOUN
dti-1337	115	48	of	of	ADP
dti-1337	115	49	the	the	DET
dti-1337	115	50	analogs	analog	NOUN
dti-1337	115	51	by	by	ADP
dti-1337	115	52	nqo1	nqo1	PROPN
dti-1337	115	53	.	.	PUNCT
dti-1337	116	1	this	this	DET
dti-1337	116	2	suggestion	suggestion	NOUN
dti-1337	116	3	is	be	AUX
dti-1337	116	4	supported	support	VERB
dti-1337	116	5	by	by	ADP
dti-1337	116	6	the	the	DET
dti-1337	116	7	fi	fi	NOUN
dti-1337	116	8	nding	nde	VERB
dti-1337	116	9	that	that	PRON
dti-1337	116	10	in	in	ADP
dti-1337	116	11	relative	relative	ADJ
dti-1337	116	12	terms	term	NOUN
dti-1337	116	13	,	,	PUNCT
dti-1337	116	14	p	p	X
dti-1337	116	15	-	-	PUNCT
dti-1337	116	16	mebm	mebm	PROPN
dti-1337	116	17	had	have	VERB
dti-1337	116	18	the	the	DET
dti-1337	116	19	largest	large	ADJ
dti-1337	116	20	growth	growth	NOUN
dti-1337	116	21	inhibitory	inhibitory	ADJ
dti-1337	116	22	effect	effect	NOUN
dti-1337	116	23	;	;	PUNCT
dti-1337	116	24	m	m	X
dti-1337	116	25	-	-	PUNCT
dti-1337	116	26	pbm	pbm	NOUN
dti-1337	116	27	had	have	VERB
dti-1337	116	28	the	the	DET
dti-1337	116	29	smallest	small	ADJ
dti-1337	116	30	inhibitory	inhibitory	ADJ
dti-1337	116	31	effect	effect	NOUN
dti-1337	116	32	,	,	PUNCT
dti-1337	116	33	and	and	CCONJ
dti-1337	116	34	the	the	DET
dti-1337	116	35	other	other	ADJ
dti-1337	116	36	bm	bm	PROPN
dti-1337	116	37	analogs	analog	NOUN
dti-1337	116	38	had	have	VERB
dti-1337	116	39	intermediate	intermediate	ADJ
dti-1337	116	40	inhibitory	inhibitory	ADJ
dti-1337	116	41	effects	effect	NOUN
dti-1337	116	42	in	in	ADP
dti-1337	116	43	all	all	DET
dti-1337	116	44	three	three	NUM
dti-1337	116	45	cell	cell	NOUN
dti-1337	116	46	lines	line	NOUN
dti-1337	116	47	.	.	PUNCT
dti-1337	117	1	when	when	SCONJ
dti-1337	117	2	we	we	PRON
dti-1337	117	3	examined	examine	VERB
dti-1337	117	4	the	the	DET
dti-1337	117	5	growth	growth	NOUN
dti-1337	117	6	inhibitory	inhibitory	ADJ
dti-1337	117	7	activities	activity	NOUN
dti-1337	117	8	of	of	ADP
dti-1337	117	9	the	the	DET
dti-1337	117	10	fi	fi	NOUN
dti-1337	117	11	ve	ve	NOUN
dti-1337	117	12	bm	bm	PROPN
dti-1337	117	13	analogs	analog	NOUN
dti-1337	117	14	within	within	ADP
dti-1337	117	15	each	each	DET
dti-1337	117	16	cell	cell	NOUN
dti-1337	117	17	line	line	NOUN
dti-1337	117	18	,	,	PUNCT
dti-1337	117	19	we	we	PRON
dti-1337	117	20	observed	observe	VERB
dti-1337	117	21	signifi	signifi	NOUN
dti-1337	117	22	ca	can	AUX
dti-1337	117	23	nt	not	PART
dti-1337	117	24	differences	difference	NOUN
dti-1337	117	25	in	in	ADP
dti-1337	117	26	the	the	DET
dti-1337	117	27	relative	relative	ADJ
dti-1337	117	28	activity	activity	NOUN
dti-1337	117	29	of	of	ADP
dti-1337	117	30	the	the	DET
dti-1337	117	31	analogs	analog	NOUN
dti-1337	117	32	in	in	ADP
dti-1337	117	33	the	the	DET
dti-1337	117	34	different	different	ADJ
dti-1337	117	35	cell	cell	NOUN
dti-1337	117	36	lines	line	NOUN
dti-1337	117	37	.	.	PUNCT
dti-1337	118	1	in	in	ADP
dti-1337	118	2	the	the	DET
dti-1337	118	3	fadu	fadu	ADJ
dti-1337	118	4	cells	cell	NOUN
dti-1337	118	5	with	with	ADP
dti-1337	118	6	the	the	DET
dti-1337	118	7	highest	high	ADJ
dti-1337	118	8	nqo1	nqo1	NOUN
dti-1337	118	9	activity	activity	NOUN
dti-1337	118	10	,	,	PUNCT
dti-1337	118	11	the	the	DET
dti-1337	118	12	relative	relative	ADJ
dti-1337	118	13	tumor	tumor	NOUN
dti-1337	118	14	cell	cell	NOUN
dti-1337	118	15	growth	growth	NOUN
dti-1337	118	16	inhibitory	inhibitory	ADJ
dti-1337	118	17	table	table	NOUN
dti-1337	118	18	1	1	NUM
dti-1337	118	19	.	.	PUNCT
dti-1337	119	1	tumor	tumor	NOUN
dti-1337	119	2	cell	cell	NOUN
dti-1337	119	3	growth	growth	NOUN
dti-1337	119	4	inhibition	inhibition	NOUN
dti-1337	119	5	by	by	ADP
dti-1337	119	6	bm	bm	PROPN
dti-1337	119	7	analogs	analog	NOUN
dti-1337	119	8	in	in	ADP
dti-1337	119	9	cell	cell	NOUN
dti-1337	119	10	lines	line	NOUN
dti-1337	119	11	with	with	ADP
dti-1337	119	12	different	different	ADJ
dti-1337	119	13	nqo1	nqo1	NOUN
dti-1337	119	14	activities	activity	NOUN
dti-1337	119	15	.	.	PUNCT
dti-1337	120	1	ic50	ic50	PROPN
dti-1337	120	2	(	(	PUNCT
dti-1337	120	3	μm	μm	NUM
dti-1337	120	4	)	)	PUNCT
dti-1337	120	5	bm	bm	PROPN
dti-1337	120	6	analog	analog	PROPN
dti-1337	120	7	fadu	fadu	PROPN
dti-1337	120	8	(	(	PUNCT
dti-1337	120	9	n)1	n)1	NOUN
dti-1337	120	10	hct116	hct116	ADV
dti-1337	120	11	(	(	PUNCT
dti-1337	120	12	n)1	n)1	PROPN
dti-1337	120	13	t47d	t47d	PRON
dti-1337	120	14	(	(	PUNCT
dti-1337	120	15	n)1	n)1	PROPN
dti-1337	120	16	p	p	X
dti-1337	120	17	-	-	PUNCT
dti-1337	120	18	mebm	mebm	NOUN
dti-1337	120	19	0.30	0.30	NUM
dti-1337	120	20	±	±	NUM
dti-1337	120	21	0.08	0.08	NUM
dti-1337	120	22	(	(	PUNCT
dti-1337	120	23	4	4	NUM
dti-1337	120	24	)	)	PUNCT
dti-1337	120	25	0.22	0.22	NUM
dti-1337	120	26	±	±	NUM
dti-1337	120	27	0.01	0.01	NUM
dti-1337	120	28	(	(	PUNCT
dti-1337	120	29	3	3	NUM
dti-1337	120	30	)	)	PUNCT
dti-1337	120	31	0.08	0.08	NUM
dti-1337	120	32	±	±	NUM
dti-1337	120	33	0.01	0.01	NUM
dti-1337	120	34	(	(	PUNCT
dti-1337	120	35	4	4	NUM
dti-1337	120	36	)	)	PUNCT
dti-1337	120	37	m	m	PROPN
dti-1337	120	38	-	-	PUNCT
dti-1337	120	39	mebm	mebm	PROPN
dti-1337	120	40	1.27	1.27	NUM
dti-1337	120	41	±	±	NUM
dti-1337	120	42	0.13	0.13	NUM
dti-1337	120	43	(	(	PUNCT
dti-1337	120	44	4	4	NUM
dti-1337	120	45	)	)	PUNCT
dti-1337	120	46	2.69	2.69	NUM
dti-1337	120	47	±	±	NUM
dti-1337	120	48	0.25	0.25	NUM
dti-1337	120	49	(	(	PUNCT
dti-1337	120	50	4	4	NUM
dti-1337	120	51	)	)	PUNCT
dti-1337	120	52	0.39	0.39	NUM
dti-1337	120	53	±	±	NUM
dti-1337	120	54	0.04	0.04	NUM
dti-1337	120	55	(	(	PUNCT
dti-1337	120	56	4	4	NUM
dti-1337	120	57	)	)	PUNCT
dti-1337	120	58	p	p	NOUN
dti-1337	120	59	-	-	PUNCT
dti-1337	120	60	pbm	pbm	NOUN
dti-1337	120	61	1.39	1.39	NUM
dti-1337	120	62	±	±	NUM
dti-1337	120	63	0.31	0.31	NUM
dti-1337	120	64	(	(	PUNCT
dti-1337	120	65	4	4	NUM
dti-1337	120	66	)	)	PUNCT
dti-1337	120	67	1.85	1.85	NUM
dti-1337	120	68	±	±	NUM
dti-1337	120	69	0.13	0.13	NUM
dti-1337	120	70	(	(	PUNCT
dti-1337	120	71	3	3	NUM
dti-1337	120	72	)	)	PUNCT
dti-1337	120	73	0.63	0.63	NUM
dti-1337	120	74	±	±	NUM
dti-1337	120	75	0.08	0.08	NUM
dti-1337	120	76	(	(	PUNCT
dti-1337	120	77	4	4	NUM
dti-1337	120	78	)	)	PUNCT
dti-1337	120	79	m	m	PROPN
dti-1337	120	80	-	-	PUNCT
dti-1337	120	81	nprbm	nprbm	PROPN
dti-1337	120	82	3.10	3.10	NUM
dti-1337	120	83	±	±	NUM
dti-1337	120	84	0.95	0.95	NUM
dti-1337	120	85	(	(	PUNCT
dti-1337	120	86	4	4	NUM
dti-1337	120	87	)	)	PUNCT
dti-1337	120	88	6.10	6.10	NUM
dti-1337	120	89	±	±	NUM
dti-1337	120	90	1.18	1.18	NUM
dti-1337	120	91	(	(	PUNCT
dti-1337	120	92	4	4	NUM
dti-1337	120	93	)	)	PUNCT
dti-1337	120	94	0.80	0.80	NUM
dti-1337	120	95	±	±	NUM
dti-1337	120	96	0.08	0.08	NUM
dti-1337	120	97	(	(	PUNCT
dti-1337	120	98	4	4	NUM
dti-1337	120	99	)	)	PUNCT
dti-1337	120	100	m	m	NOUN
dti-1337	120	101	-	-	PUNCT
dti-1337	120	102	pbm	pbm	NOUN
dti-1337	120	103	5.77	5.77	NUM
dti-1337	120	104	±	±	NUM
dti-1337	120	105	1.31	1.31	NUM
dti-1337	120	106	(	(	PUNCT
dti-1337	120	107	4	4	NUM
dti-1337	120	108	)	)	PUNCT
dti-1337	120	109	6.68	6.68	NUM
dti-1337	120	110	±	±	NUM
dti-1337	120	111	1.53	1.53	NUM
dti-1337	120	112	(	(	PUNCT
dti-1337	120	113	3	3	NUM
dti-1337	120	114	)	)	PUNCT
dti-1337	120	115	0.76	0.76	NUM
dti-1337	120	116	±	±	NUM
dti-1337	120	117	0.02	0.02	NUM
dti-1337	120	118	(	(	PUNCT
dti-1337	120	119	3	3	NUM
dti-1337	120	120	)	)	PUNCT
dti-1337	120	121	1mean	1mean	NUM
dti-1337	120	122	±	±	NUM
dti-1337	120	123	sem	sem	NOUN
dti-1337	120	124	.	.	PUNCT
dti-1337	121	1	n	n	NOUN
dti-1337	121	2	=	=	NOUN
dti-1337	121	3	number	number	NOUN
dti-1337	121	4	of	of	ADP
dti-1337	121	5	determinations	determination	NOUN
dti-1337	121	6	.	.	PUNCT
dti-1337	122	1	7	7	NUM
dti-1337	122	2	a	a	DET
dti-1337	122	3	model	model	NOUN
dti-1337	122	4	for	for	ADP
dti-1337	122	5	nqo1	nqo1	NOUN
dti-1337	122	6	targeted	target	VERB
dti-1337	122	7	individualized	individualized	ADJ
dti-1337	122	8	chemotherapy	chemotherapy	NOUN
dti-1337	122	9	drug	drug	NOUN
dti-1337	122	10	target	target	NOUN
dti-1337	122	11	insights	insight	NOUN
dti-1337	122	12	2009:4	2009:4	NUM
dti-1337	122	13	activity	activity	NOUN
dti-1337	122	14	was	be	AUX
dti-1337	122	15	p	p	ADJ
dti-1337	122	16	-	-	PUNCT
dti-1337	122	17	mebm	mebm	NOUN
dti-1337	122	18	�	�	PROPN
dti-1337	122	19	m	m	PROPN
dti-1337	122	20	-	-	PUNCT
dti-1337	122	21	mebm	mebm	X
dti-1337	122	22	=	=	PUNCT
dti-1337	123	1	p	p	X
dti-1337	123	2	-	-	PUNCT
dti-1337	123	3	pbm	pbm	NOUN
dti-1337	123	4	�	�	PROPN
dti-1337	123	5	m	m	PROPN
dti-1337	123	6	-	-	PUNCT
dti-1337	123	7	nprbm	nprbm	PROPN
dti-1337	123	8	�	�	PROPN
dti-1337	123	9	m	m	NOUN
dti-1337	123	10	-	-	PUNCT
dti-1337	123	11	pbm	pbm	NOUN
dti-1337	123	12	.	.	PUNCT
dti-1337	124	1	this	this	PRON
dti-1337	124	2	suggests	suggest	VERB
dti-1337	124	3	that	that	SCONJ
dti-1337	124	4	p	p	PROPN
dti-1337	124	5	-	-	PUNCT
dti-1337	124	6	mebm	mebm	PROPN
dti-1337	124	7	was	be	AUX
dti-1337	124	8	most	most	ADV
dti-1337	124	9	activated	activate	VERB
dti-1337	124	10	;	;	PUNCT
dti-1337	124	11	m	m	NOUN
dti-1337	124	12	-	-	PUNCT
dti-1337	124	13	mebm	mebm	NOUN
dti-1337	124	14	and	and	CCONJ
dti-1337	124	15	p	p	NOUN
dti-1337	124	16	-	-	PUNCT
dti-1337	124	17	pbm	pbm	NOUN
dti-1337	124	18	were	be	AUX
dti-1337	124	19	substantially	substantially	ADV
dti-1337	124	20	activated	activate	VERB
dti-1337	124	21	;	;	PUNCT
dti-1337	124	22	m	m	NOUN
dti-1337	124	23	-	-	PUNCT
dti-1337	124	24	nprbm	nprbm	PROPN
dti-1337	124	25	was	be	AUX
dti-1337	124	26	somewhat	somewhat	ADV
dti-1337	124	27	activated	activate	VERB
dti-1337	124	28	,	,	PUNCT
dti-1337	124	29	and	and	CCONJ
dti-1337	124	30	m	m	NOUN
dti-1337	124	31	-	-	PUNCT
dti-1337	124	32	pbm	pbm	NOUN
dti-1337	124	33	was	be	AUX
dti-1337	124	34	poorly	poorly	ADV
dti-1337	124	35	activated	activate	VERB
dti-1337	124	36	by	by	ADP
dti-1337	124	37	the	the	DET
dti-1337	124	38	level	level	NOUN
dti-1337	124	39	of	of	ADP
dti-1337	124	40	nqo1	nqo1	NOUN
dti-1337	124	41	in	in	ADP
dti-1337	124	42	these	these	DET
dti-1337	124	43	cells	cell	NOUN
dti-1337	124	44	.	.	PUNCT
dti-1337	125	1	this	this	PRON
dti-1337	125	2	is	be	AUX
dti-1337	125	3	consistent	consistent	ADJ
dti-1337	125	4	with	with	ADP
dti-1337	125	5	our	our	PRON
dti-1337	125	6	hypothesis	hypothesis	NOUN
dti-1337	125	7	based	base	VERB
dti-1337	125	8	on	on	ADP
dti-1337	125	9	the	the	DET
dti-1337	125	10	steric	steric	ADJ
dti-1337	125	11	size	size	NOUN
dti-1337	125	12	and	and	CCONJ
dti-1337	125	13	location	location	NOUN
dti-1337	125	14	of	of	ADP
dti-1337	125	15	the	the	DET
dti-1337	125	16	functional	functional	ADJ
dti-1337	125	17	groups	group	NOUN
dti-1337	125	18	.	.	PUNCT
dti-1337	126	1	in	in	ADP
dti-1337	126	2	the	the	DET
dti-1337	126	3	hct116	hct116	PROPN
dti-1337	126	4	cells	cell	NOUN
dti-1337	126	5	with	with	ADP
dti-1337	126	6	an	an	DET
dti-1337	126	7	intermediate	intermediate	ADJ
dti-1337	126	8	level	level	NOUN
dti-1337	126	9	of	of	ADP
dti-1337	126	10	nqo1	nqo1	NOUN
dti-1337	126	11	activity	activity	NOUN
dti-1337	126	12	,	,	PUNCT
dti-1337	126	13	the	the	DET
dti-1337	126	14	relative	relative	ADJ
dti-1337	126	15	inhibitory	inhibitory	ADJ
dti-1337	126	16	activity	activity	NOUN
dti-1337	126	17	was	be	AUX
dti-1337	126	18	p	p	ADJ
dti-1337	126	19	-	-	PUNCT
dti-1337	126	20	mebm	mebm	NOUN
dti-1337	126	21	�	�	PROPN
dti-1337	126	22	m	m	PROPN
dti-1337	126	23	-	-	PUNCT
dti-1337	126	24	mebm	mebm	X
dti-1337	126	25	=	=	PUNCT
dti-1337	127	1	p	p	X
dti-1337	127	2	-	-	PUNCT
dti-1337	127	3	pbm	pbm	NOUN
dti-1337	127	4	�	�	PROPN
dti-1337	127	5	m	m	PROPN
dti-1337	127	6	-	-	PROPN
dti-1337	127	7	nprbm	nprbm	PROPN
dti-1337	127	8	=	=	PUNCT
dti-1337	127	9	m	m	NOUN
dti-1337	127	10	-	-	PUNCT
dti-1337	127	11	pbm	pbm	NOUN
dti-1337	127	12	,	,	PUNCT
dti-1337	127	13	suggesting	suggest	VERB
dti-1337	127	14	that	that	SCONJ
dti-1337	127	15	p	p	PROPN
dti-1337	127	16	-	-	PUNCT
dti-1337	127	17	mebm	mebm	PROPN
dti-1337	127	18	was	be	AUX
dti-1337	127	19	most	most	ADV
dti-1337	127	20	activated	activate	VERB
dti-1337	127	21	;	;	PUNCT
dti-1337	127	22	m	m	NOUN
dti-1337	127	23	-	-	PUNCT
dti-1337	127	24	mebm	mebm	NOUN
dti-1337	127	25	and	and	CCONJ
dti-1337	127	26	ppbm	ppbm	NOUN
dti-1337	127	27	were	be	AUX
dti-1337	127	28	substantially	substantially	ADV
dti-1337	127	29	activated	activate	VERB
dti-1337	127	30	,	,	PUNCT
dti-1337	127	31	and	and	CCONJ
dti-1337	127	32	m	m	PROPN
dti-1337	127	33	-	-	PUNCT
dti-1337	127	34	nprbm	nprbm	PROPN
dti-1337	127	35	and	and	CCONJ
dti-1337	127	36	m	m	NOUN
dti-1337	127	37	-	-	PUNCT
dti-1337	127	38	pbm	pbm	NOUN
dti-1337	127	39	were	be	AUX
dti-1337	127	40	poorly	poorly	ADV
dti-1337	127	41	activated	activate	VERB
dti-1337	127	42	by	by	ADP
dti-1337	127	43	the	the	DET
dti-1337	127	44	level	level	NOUN
dti-1337	127	45	of	of	ADP
dti-1337	127	46	nqo1	nqo1	NOUN
dti-1337	127	47	in	in	ADP
dti-1337	127	48	these	these	DET
dti-1337	127	49	cells	cell	NOUN
dti-1337	127	50	.	.	PUNCT
dti-1337	128	1	this	this	PRON
dti-1337	128	2	represents	represent	VERB
dti-1337	128	3	a	a	DET
dti-1337	128	4	decrease	decrease	NOUN
dti-1337	128	5	in	in	ADP
dti-1337	128	6	the	the	DET
dti-1337	128	7	relative	relative	ADJ
dti-1337	128	8	growth	growth	NOUN
dti-1337	128	9	inhibitory	inhibitory	ADJ
dti-1337	128	10	effect	effect	NOUN
dti-1337	128	11	of	of	ADP
dti-1337	128	12	m	m	PROPN
dti-1337	128	13	-	-	NOUN
dti-1337	128	14	nprbm	nprbm	NOUN
dti-1337	128	15	in	in	ADP
dti-1337	128	16	the	the	DET
dti-1337	128	17	hct116	hct116	PROPN
dti-1337	128	18	cells	cell	NOUN
dti-1337	128	19	compared	compare	VERB
dti-1337	128	20	with	with	ADP
dti-1337	128	21	the	the	DET
dti-1337	128	22	fadu	fadu	ADJ
dti-1337	128	23	cells	cell	NOUN
dti-1337	128	24	.	.	PUNCT
dti-1337	129	1	this	this	PRON
dti-1337	129	2	suggests	suggest	VERB
dti-1337	129	3	that	that	SCONJ
dti-1337	129	4	the	the	DET
dti-1337	129	5	n	n	CCONJ
dti-1337	129	6	-	-	PUNCT
dti-1337	129	7	propyl	propyl	ADJ
dti-1337	129	8	functional	functional	ADJ
dti-1337	129	9	group	group	NOUN
dti-1337	129	10	at	at	ADP
dti-1337	129	11	the	the	DET
dti-1337	129	12	c6	c6	PROPN
dti-1337	129	13	position	position	NOUN
dti-1337	129	14	produces	produce	VERB
dti-1337	129	15	a	a	DET
dti-1337	129	16	greater	great	ADJ
dti-1337	129	17	steric	steric	ADJ
dti-1337	129	18	effect	effect	NOUN
dti-1337	129	19	than	than	ADP
dti-1337	129	20	the	the	DET
dti-1337	129	21	methyl	methyl	NOUN
dti-1337	129	22	group	group	NOUN
dti-1337	129	23	at	at	ADP
dti-1337	129	24	the	the	DET
dti-1337	129	25	c6	c6	PROPN
dti-1337	129	26	position	position	NOUN
dti-1337	129	27	and	and	CCONJ
dti-1337	129	28	the	the	DET
dti-1337	129	29	phenyl	phenyl	NOUN
dti-1337	129	30	group	group	NOUN
dti-1337	129	31	at	at	ADP
dti-1337	129	32	the	the	DET
dti-1337	129	33	c5	c5	PROPN
dti-1337	129	34	position	position	NOUN
dti-1337	129	35	.	.	PUNCT
dti-1337	130	1	in	in	ADP
dti-1337	130	2	addition	addition	NOUN
dti-1337	130	3	,	,	PUNCT
dti-1337	130	4	this	this	DET
dti-1337	130	5	result	result	NOUN
dti-1337	130	6	suggests	suggest	VERB
dti-1337	130	7	that	that	SCONJ
dti-1337	130	8	m	m	PROPN
dti-1337	130	9	-	-	PUNCT
dti-1337	130	10	nprbm	nprbm	PROPN
dti-1337	130	11	would	would	AUX
dti-1337	130	12	not	not	PART
dti-1337	130	13	be	be	AUX
dti-1337	130	14	fully	fully	ADV
dti-1337	130	15	activated	activate	VERB
dti-1337	130	16	in	in	ADP
dti-1337	130	17	tumors	tumor	NOUN
dti-1337	130	18	with	with	ADP
dti-1337	130	19	intermediate	intermediate	ADJ
dti-1337	130	20	levels	level	NOUN
dti-1337	130	21	of	of	ADP
dti-1337	130	22	nqo1	nqo1	PROPN
dti-1337	130	23	and	and	CCONJ
dti-1337	130	24	would	would	AUX
dti-1337	130	25	only	only	ADV
dti-1337	130	26	be	be	AUX
dti-1337	130	27	maximally	maximally	ADV
dti-1337	130	28	effective	effective	ADJ
dti-1337	130	29	in	in	ADP
dti-1337	130	30	tumors	tumor	NOUN
dti-1337	130	31	with	with	ADP
dti-1337	130	32	high	high	ADJ
dti-1337	130	33	levels	level	NOUN
dti-1337	130	34	of	of	ADP
dti-1337	130	35	nqo1	nqo1	NOUN
dti-1337	130	36	activity	activity	NOUN
dti-1337	130	37	.	.	PUNCT
dti-1337	131	1	in	in	ADP
dti-1337	131	2	t47d	t47d	DET
dti-1337	131	3	cells	cell	NOUN
dti-1337	131	4	with	with	ADP
dti-1337	131	5	the	the	DET
dti-1337	131	6	lowest	low	ADJ
dti-1337	131	7	nqo1	nqo1	NOUN
dti-1337	131	8	activity	activity	NOUN
dti-1337	131	9	,	,	PUNCT
dti-1337	131	10	the	the	DET
dti-1337	131	11	relative	relative	ADJ
dti-1337	131	12	growth	growth	NOUN
dti-1337	131	13	inhibitory	inhibitory	ADJ
dti-1337	131	14	activity	activity	NOUN
dti-1337	131	15	was	be	AUX
dti-1337	131	16	p	p	ADJ
dti-1337	131	17	-	-	PUNCT
dti-1337	131	18	mebm	mebm	NOUN
dti-1337	131	19	�	�	PROPN
dti-1337	131	20	m	m	PROPN
dti-1337	131	21	-	-	PUNCT
dti-1337	131	22	mebm	mebm	NOUN
dti-1337	131	23	�	�	PROPN
dti-1337	132	1	p	p	NOUN
dti-1337	132	2	-	-	PUNCT
dti-1337	132	3	pbm	pbm	NOUN
dti-1337	132	4	=	=	NOUN
dti-1337	132	5	m	m	NOUN
dti-1337	132	6	-	-	PUNCT
dti-1337	132	7	nprbm	nprbm	PROPN
dti-1337	132	8	=	=	PUNCT
dti-1337	132	9	m	m	NOUN
dti-1337	132	10	-	-	PUNCT
dti-1337	132	11	pbm	pbm	NOUN
dti-1337	132	12	,	,	PUNCT
dti-1337	132	13	suggesting	suggest	VERB
dti-1337	132	14	that	that	SCONJ
dti-1337	132	15	p	p	PROPN
dti-1337	132	16	-	-	PUNCT
dti-1337	132	17	mebm	mebm	PROPN
dti-1337	132	18	was	be	AUX
dti-1337	132	19	most	most	ADV
dti-1337	132	20	activated	activate	VERB
dti-1337	132	21	;	;	PUNCT
dti-1337	132	22	m	m	NOUN
dti-1337	132	23	-	-	PUNCT
dti-1337	132	24	mebm	mebm	PROPN
dti-1337	132	25	was	be	AUX
dti-1337	132	26	substantially	substantially	ADV
dti-1337	132	27	activated	activate	VERB
dti-1337	132	28	,	,	PUNCT
dti-1337	132	29	and	and	CCONJ
dti-1337	132	30	p	p	X
dti-1337	132	31	-	-	PUNCT
dti-1337	132	32	pbm	pbm	NOUN
dti-1337	132	33	,	,	PUNCT
dti-1337	132	34	m	m	PROPN
dti-1337	132	35	-	-	PUNCT
dti-1337	132	36	nprbm	nprbm	PROPN
dti-1337	132	37	and	and	CCONJ
dti-1337	132	38	m	m	NOUN
dti-1337	132	39	-	-	PUNCT
dti-1337	132	40	pbm	pbm	NOUN
dti-1337	132	41	were	be	AUX
dti-1337	132	42	poorly	poorly	ADV
dti-1337	132	43	activated	activate	VERB
dti-1337	132	44	by	by	ADP
dti-1337	132	45	the	the	DET
dti-1337	132	46	level	level	NOUN
dti-1337	132	47	of	of	ADP
dti-1337	132	48	nqo1	nqo1	NOUN
dti-1337	132	49	in	in	ADP
dti-1337	132	50	these	these	DET
dti-1337	132	51	cells	cell	NOUN
dti-1337	132	52	.	.	PUNCT
dti-1337	133	1	this	this	PRON
dti-1337	133	2	represents	represent	VERB
dti-1337	133	3	a	a	DET
dti-1337	133	4	decrease	decrease	NOUN
dti-1337	133	5	in	in	ADP
dti-1337	133	6	the	the	DET
dti-1337	133	7	relative	relative	ADJ
dti-1337	133	8	growth	growth	NOUN
dti-1337	133	9	inhibitory	inhibitory	ADJ
dti-1337	133	10	effect	effect	NOUN
dti-1337	133	11	of	of	ADP
dti-1337	133	12	p	p	NOUN
dti-1337	133	13	-	-	PUNCT
dti-1337	133	14	pbm	pbm	NOUN
dti-1337	133	15	in	in	ADP
dti-1337	133	16	t47d	t47d	DET
dti-1337	133	17	cells	cell	NOUN
dti-1337	133	18	compared	compare	VERB
dti-1337	133	19	with	with	ADP
dti-1337	133	20	hct116	hct116	PROPN
dti-1337	133	21	cells	cell	NOUN
dti-1337	133	22	.	.	PUNCT
dti-1337	134	1	this	this	DET
dti-1337	134	2	result	result	NOUN
dti-1337	134	3	suggests	suggest	VERB
dti-1337	134	4	that	that	SCONJ
dti-1337	134	5	p	p	X
dti-1337	134	6	-	-	PUNCT
dti-1337	134	7	pbm	pbm	NOUN
dti-1337	134	8	would	would	AUX
dti-1337	134	9	not	not	PART
dti-1337	134	10	be	be	AUX
dti-1337	134	11	fully	fully	ADV
dti-1337	134	12	activated	activate	VERB
dti-1337	134	13	in	in	ADP
dti-1337	134	14	tumors	tumor	NOUN
dti-1337	134	15	with	with	ADP
dti-1337	134	16	low	low	ADJ
dti-1337	134	17	levels	level	NOUN
dti-1337	134	18	of	of	ADP
dti-1337	134	19	nqo1	nqo1	PROPN
dti-1337	134	20	and	and	CCONJ
dti-1337	134	21	would	would	AUX
dti-1337	134	22	only	only	ADV
dti-1337	134	23	be	be	AUX
dti-1337	134	24	effective	effective	ADJ
dti-1337	134	25	in	in	ADP
dti-1337	134	26	tumors	tumor	NOUN
dti-1337	134	27	with	with	ADP
dti-1337	134	28	average	average	ADJ
dti-1337	134	29	or	or	CCONJ
dti-1337	134	30	higher	high	ADJ
dti-1337	134	31	nqo1	nqo1	NOUN
dti-1337	134	32	activity	activity	NOUN
dti-1337	134	33	.	.	PUNCT
dti-1337	135	1	furthermore	furthermore	ADV
dti-1337	135	2	,	,	PUNCT
dti-1337	135	3	these	these	DET
dti-1337	135	4	fi	fi	NOUN
dti-1337	135	5	ndings	nding	NOUN
dti-1337	135	6	indicate	indicate	VERB
dti-1337	135	7	that	that	SCONJ
dti-1337	135	8	m	m	NOUN
dti-1337	135	9	-	-	PUNCT
dti-1337	135	10	mebm	mebm	NOUN
dti-1337	135	11	and	and	CCONJ
dti-1337	135	12	p	p	X
dti-1337	135	13	-	-	PUNCT
dti-1337	135	14	mebm	mebm	NOUN
dti-1337	135	15	are	be	AUX
dti-1337	135	16	at	at	ADV
dti-1337	135	17	least	least	ADJ
dti-1337	135	18	partially	partially	ADV
dti-1337	135	19	activated	activate	VERB
dti-1337	135	20	in	in	ADP
dti-1337	135	21	cells	cell	NOUN
dti-1337	135	22	with	with	ADP
dti-1337	135	23	low	low	ADJ
dti-1337	135	24	levels	level	NOUN
dti-1337	135	25	of	of	ADP
dti-1337	135	26	nqo1	nqo1	NOUN
dti-1337	135	27	activity	activity	NOUN
dti-1337	135	28	like	like	ADP
dti-1337	135	29	bone	bone	NOUN
dti-1337	135	30	marrow	marrow	NOUN
dti-1337	135	31	cells	cell	NOUN
dti-1337	135	32	,	,	PUNCT
dti-1337	135	33	and	and	CCONJ
dti-1337	135	34	would	would	AUX
dti-1337	135	35	likely	likely	ADV
dti-1337	135	36	produce	produce	VERB
dti-1337	135	37	some	some	DET
dti-1337	135	38	bone	bone	NOUN
dti-1337	135	39	marrow	marrow	NOUN
dti-1337	135	40	toxicity	toxicity	NOUN
dti-1337	135	41	.	.	PUNCT
dti-1337	136	1	since	since	SCONJ
dti-1337	136	2	m	m	PROPN
dti-1337	136	3	-	-	PUNCT
dti-1337	136	4	nprbm	nprbm	PROPN
dti-1337	136	5	and	and	CCONJ
dti-1337	136	6	p	p	NOUN
dti-1337	136	7	-	-	PUNCT
dti-1337	136	8	pbm	pbm	NOUN
dti-1337	136	9	showed	show	VERB
dti-1337	136	10	good	good	ADJ
dti-1337	136	11	tumor	tumor	NOUN
dti-1337	136	12	cell	cell	NOUN
dti-1337	136	13	growth	growth	NOUN
dti-1337	136	14	inhibition	inhibition	NOUN
dti-1337	136	15	in	in	ADP
dti-1337	136	16	the	the	DET
dti-1337	136	17	fadu	fadu	ADJ
dti-1337	136	18	cells	cell	NOUN
dti-1337	136	19	but	but	CCONJ
dti-1337	136	20	poor	poor	ADJ
dti-1337	136	21	activity	activity	NOUN
dti-1337	136	22	in	in	ADP
dti-1337	136	23	the	the	DET
dti-1337	136	24	t47d	t47d	PROPN
dti-1337	136	25	cells	cell	NOUN
dti-1337	136	26	,	,	PUNCT
dti-1337	136	27	these	these	DET
dti-1337	136	28	bm	bm	PROPN
dti-1337	136	29	analogs	analog	NOUN
dti-1337	136	30	would	would	AUX
dti-1337	136	31	likely	likely	ADV
dti-1337	136	32	have	have	VERB
dti-1337	136	33	good	good	ADJ
dti-1337	136	34	antitumor	antitumor	PROPN
dti-1337	136	35	activity	activity	NOUN
dti-1337	136	36	in	in	ADP
dti-1337	136	37	tumors	tumor	NOUN
dti-1337	136	38	with	with	ADP
dti-1337	136	39	high	high	ADJ
dti-1337	136	40	nqo1	nqo1	NOUN
dti-1337	136	41	activity	activity	NOUN
dti-1337	136	42	but	but	CCONJ
dti-1337	136	43	little	little	ADJ
dti-1337	136	44	activity	activity	NOUN
dti-1337	136	45	in	in	ADP
dti-1337	136	46	bone	bone	NOUN
dti-1337	136	47	marrow	marrow	NOUN
dti-1337	136	48	cells	cell	NOUN
dti-1337	136	49	.	.	PUNCT
dti-1337	137	1	because	because	SCONJ
dti-1337	137	2	p	p	NOUN
dti-1337	137	3	-	-	PUNCT
dti-1337	137	4	pbm	pbm	NOUN
dti-1337	137	5	also	also	ADV
dti-1337	137	6	showed	show	VERB
dti-1337	137	7	good	good	ADJ
dti-1337	137	8	growth	growth	NOUN
dti-1337	137	9	inhibition	inhibition	NOUN
dti-1337	137	10	in	in	ADP
dti-1337	137	11	hct116	hct116	PROPN
dti-1337	137	12	cells	cell	NOUN
dti-1337	137	13	,	,	PUNCT
dti-1337	137	14	it	it	PRON
dti-1337	137	15	would	would	AUX
dti-1337	137	16	likely	likely	ADV
dti-1337	137	17	also	also	ADV
dti-1337	137	18	have	have	VERB
dti-1337	137	19	good	good	ADJ
dti-1337	137	20	antitumor	antitumor	PROPN
dti-1337	137	21	activity	activity	NOUN
dti-1337	137	22	in	in	ADP
dti-1337	137	23	tumors	tumor	NOUN
dti-1337	137	24	with	with	ADP
dti-1337	137	25	average	average	ADJ
dti-1337	137	26	levels	level	NOUN
dti-1337	137	27	of	of	ADP
dti-1337	137	28	nqo1	nqo1	PROPN
dti-1337	137	29	,	,	PUNCT
dti-1337	137	30	again	again	ADV
dti-1337	137	31	with	with	ADP
dti-1337	137	32	little	little	ADJ
dti-1337	137	33	bone	bone	NOUN
dti-1337	137	34	marrow	marrow	NOUN
dti-1337	137	35	toxicity	toxicity	NOUN
dti-1337	137	36	.	.	PUNCT
dti-1337	138	1	thus	thus	ADV
dti-1337	138	2	,	,	PUNCT
dti-1337	138	3	m	m	PROPN
dti-1337	138	4	-	-	PUNCT
dti-1337	138	5	nprbm	nprbm	PROPN
dti-1337	138	6	or	or	CCONJ
dti-1337	138	7	p	p	NOUN
dti-1337	138	8	-	-	PUNCT
dti-1337	138	9	pbm	pbm	NOUN
dti-1337	138	10	might	might	AUX
dti-1337	138	11	be	be	AUX
dti-1337	138	12	suitable	suitable	ADJ
dti-1337	138	13	agents	agent	NOUN
dti-1337	138	14	for	for	ADP
dti-1337	138	15	use	use	NOUN
dti-1337	138	16	in	in	ADP
dti-1337	138	17	patients	patient	NOUN
dti-1337	138	18	having	have	VERB
dti-1337	138	19	tumors	tumor	NOUN
dti-1337	138	20	with	with	ADP
dti-1337	138	21	high	high	ADJ
dti-1337	138	22	nqo1	nqo1	NOUN
dti-1337	138	23	;	;	PUNCT
dti-1337	138	24	p	p	X
dti-1337	138	25	-	-	PUNCT
dti-1337	138	26	pbm	pbm	NOUN
dti-1337	138	27	might	might	AUX
dti-1337	138	28	be	be	AUX
dti-1337	138	29	suitable	suitable	ADJ
dti-1337	138	30	for	for	ADP
dti-1337	138	31	use	use	NOUN
dti-1337	138	32	in	in	ADP
dti-1337	138	33	patients	patient	NOUN
dti-1337	138	34	having	have	VERB
dti-1337	138	35	tumors	tumor	NOUN
dti-1337	138	36	with	with	ADP
dti-1337	138	37	average	average	ADJ
dti-1337	138	38	nqo1	nqo1	NOUN
dti-1337	138	39	,	,	PUNCT
dti-1337	138	40	and	and	CCONJ
dti-1337	138	41	m	m	PROPN
dti-1337	138	42	-	-	PUNCT
dti-1337	138	43	mebm	mebm	PROPN
dti-1337	138	44	might	might	AUX
dti-1337	138	45	be	be	AUX
dti-1337	138	46	used	use	VERB
dti-1337	138	47	in	in	ADP
dti-1337	138	48	patients	patient	NOUN
dti-1337	138	49	having	have	VERB
dti-1337	138	50	tumors	tumor	NOUN
dti-1337	138	51	with	with	ADP
dti-1337	138	52	low	low	ADJ
dti-1337	138	53	nqo1	nqo1	NOUN
dti-1337	138	54	.	.	PUNCT
dti-1337	139	1	however	however	ADV
dti-1337	139	2	,	,	PUNCT
dti-1337	139	3	the	the	DET
dti-1337	139	4	use	use	NOUN
dti-1337	139	5	of	of	ADP
dti-1337	139	6	m	m	PROPN
dti-1337	139	7	-	-	PUNCT
dti-1337	139	8	mebm	mebm	PROPN
dti-1337	139	9	would	would	AUX
dti-1337	139	10	likely	likely	ADV
dti-1337	139	11	result	result	VERB
dti-1337	139	12	in	in	ADP
dti-1337	139	13	at	at	ADP
dti-1337	139	14	least	least	ADJ
dti-1337	139	15	some	some	PRON
dti-1337	139	16	bone	bone	NOUN
dti-1337	139	17	marrow	marrow	NOUN
dti-1337	139	18	toxicity	toxicity	NOUN
dti-1337	139	19	.	.	PUNCT
dti-1337	140	1	the	the	DET
dti-1337	140	2	use	use	NOUN
dti-1337	140	3	of	of	ADP
dti-1337	140	4	p	p	NOUN
dti-1337	140	5	-	-	PUNCT
dti-1337	140	6	mebm	mebm	NOUN
dti-1337	140	7	would	would	AUX
dti-1337	140	8	likely	likely	ADV
dti-1337	140	9	produce	produce	VERB
dti-1337	140	10	signifi	signifi	NOUN
dti-1337	140	11	ca	can	AUX
dti-1337	140	12	nt	not	PART
dti-1337	140	13	bone	bone	VERB
dti-1337	140	14	marrow	marrow	NOUN
dti-1337	140	15	toxicity	toxicity	NOUN
dti-1337	140	16	in	in	ADP
dti-1337	140	17	most	most	ADJ
dti-1337	140	18	patients	patient	NOUN
dti-1337	140	19	.	.	PUNCT
dti-1337	141	1	these	these	DET
dti-1337	141	2	results	result	NOUN
dti-1337	141	3	demonstrate	demonstrate	VERB
dti-1337	141	4	the	the	DET
dti-1337	141	5	potential	potential	NOUN
dti-1337	141	6	of	of	ADP
dti-1337	141	7	using	use	VERB
dti-1337	141	8	a	a	DET
dti-1337	141	9	series	series	NOUN
dti-1337	141	10	of	of	ADP
dti-1337	141	11	bioreductive	bioreductive	ADJ
dti-1337	141	12	agents	agent	NOUN
dti-1337	141	13	with	with	ADP
dti-1337	141	14	different	different	ADJ
dti-1337	141	15	affi	affi	PROPN
dti-1337	141	16	nities	nitie	NOUN
dti-1337	141	17	for	for	ADP
dti-1337	141	18	activation	activation	NOUN
dti-1337	141	19	by	by	ADP
dti-1337	141	20	nqo1	nqo1	NOUN
dti-1337	141	21	for	for	ADP
dti-1337	141	22	targeted	target	VERB
dti-1337	141	23	individualized	individualized	ADJ
dti-1337	141	24	cancer	cancer	NOUN
dti-1337	141	25	chemotherapy	chemotherapy	NOUN
dti-1337	141	26	.	.	PUNCT
dti-1337	142	1	they	they	PRON
dti-1337	142	2	also	also	ADV
dti-1337	142	3	suggest	suggest	VERB
dti-1337	142	4	that	that	SCONJ
dti-1337	142	5	using	use	VERB
dti-1337	142	6	functional	functional	ADJ
dti-1337	142	7	groups	group	NOUN
dti-1337	142	8	of	of	ADP
dti-1337	142	9	varying	vary	VERB
dti-1337	142	10	steric	steric	ADJ
dti-1337	142	11	size	size	NOUN
dti-1337	142	12	with	with	ADP
dti-1337	142	13	quinone	quinone	NOUN
dti-1337	142	14	based	base	VERB
dti-1337	142	15	bioreductive	bioreductive	ADJ
dti-1337	142	16	agents	agent	NOUN
dti-1337	142	17	represents	represent	VERB
dti-1337	142	18	a	a	DET
dti-1337	142	19	feasible	feasible	ADJ
dti-1337	142	20	approach	approach	NOUN
dti-1337	142	21	to	to	ADP
dti-1337	142	22	designing	design	VERB
dti-1337	142	23	new	new	ADJ
dti-1337	142	24	agents	agent	NOUN
dti-1337	142	25	with	with	ADP
dti-1337	142	26	a	a	DET
dti-1337	142	27	range	range	NOUN
dti-1337	142	28	of	of	ADP
dti-1337	142	29	affi	affi	PROPN
dti-1337	142	30	nities	nitie	NOUN
dti-1337	142	31	for	for	ADP
dti-1337	142	32	activation	activation	NOUN
dti-1337	142	33	by	by	ADP
dti-1337	142	34	nqo1	nqo1	PROPN
dti-1337	142	35	.	.	PUNCT
dti-1337	143	1	in	in	ADP
dti-1337	143	2	summary	summary	NOUN
dti-1337	143	3	this	this	DET
dti-1337	143	4	study	study	NOUN
dti-1337	143	5	has	have	AUX
dti-1337	143	6	demonstrated	demonstrate	VERB
dti-1337	143	7	that	that	SCONJ
dti-1337	143	8	functional	functional	ADJ
dti-1337	143	9	groups	group	NOUN
dti-1337	143	10	of	of	ADP
dti-1337	143	11	different	different	ADJ
dti-1337	143	12	steric	steric	ADJ
dti-1337	143	13	size	size	NOUN
dti-1337	143	14	can	can	AUX
dti-1337	143	15	be	be	AUX
dti-1337	143	16	used	use	VERB
dti-1337	143	17	to	to	PART
dti-1337	143	18	produce	produce	VERB
dti-1337	143	19	a	a	DET
dti-1337	143	20	series	series	NOUN
dti-1337	143	21	of	of	ADP
dti-1337	143	22	bioreductive	bioreductive	ADJ
dti-1337	143	23	antitumor	antitumor	PROPN
dti-1337	143	24	agents	agent	NOUN
dti-1337	143	25	that	that	PRON
dti-1337	143	26	are	be	AUX
dti-1337	143	27	activated	activate	VERB
dti-1337	143	28	by	by	ADP
dti-1337	143	29	different	different	ADJ
dti-1337	143	30	levels	level	NOUN
dti-1337	143	31	of	of	ADP
dti-1337	143	32	nqo1	nqo1	PROPN
dti-1337	143	33	in	in	ADP
dti-1337	143	34	tumor	tumor	NOUN
dti-1337	143	35	cells	cell	NOUN
dti-1337	143	36	.	.	PUNCT
dti-1337	144	1	a	a	DET
dti-1337	144	2	series	series	NOUN
dti-1337	144	3	of	of	ADP
dti-1337	144	4	drugs	drug	NOUN
dti-1337	144	5	of	of	ADP
dti-1337	144	6	this	this	DET
dti-1337	144	7	type	type	NOUN
dti-1337	144	8	might	might	AUX
dti-1337	144	9	be	be	AUX
dti-1337	144	10	used	use	VERB
dti-1337	144	11	to	to	PART
dti-1337	144	12	target	target	VERB
dti-1337	144	13	cells	cell	NOUN
dti-1337	144	14	with	with	ADP
dti-1337	144	15	specifi	specifi	PROPN
dti-1337	144	16	c	c	PROPN
dti-1337	144	17	levels	level	NOUN
dti-1337	144	18	of	of	ADP
dti-1337	144	19	nqo1	nqo1	NOUN
dti-1337	144	20	for	for	ADP
dti-1337	144	21	growth	growth	NOUN
dti-1337	144	22	inhibition	inhibition	NOUN
dti-1337	144	23	and	and	CCONJ
dti-1337	144	24	to	to	PART
dti-1337	144	25	avoid	avoid	VERB
dti-1337	144	26	damage	damage	NOUN
dti-1337	144	27	to	to	ADP
dti-1337	144	28	normal	normal	ADJ
dti-1337	144	29	cells	cell	NOUN
dti-1337	144	30	,	,	PUNCT
dti-1337	144	31	like	like	ADP
dti-1337	144	32	bone	bone	NOUN
dti-1337	144	33	marrow	marrow	NOUN
dti-1337	144	34	cells	cell	NOUN
dti-1337	144	35	,	,	PUNCT
dti-1337	144	36	that	that	PRON
dti-1337	144	37	have	have	VERB
dti-1337	144	38	low	low	ADJ
dti-1337	144	39	levels	level	NOUN
dti-1337	144	40	of	of	ADP
dti-1337	144	41	nqo1	nqo1	PROPN
dti-1337	144	42	.	.	PUNCT
dti-1337	145	1	this	this	DET
dti-1337	145	2	approach	approach	NOUN
dti-1337	145	3	could	could	AUX
dti-1337	145	4	be	be	AUX
dti-1337	145	5	used	use	VERB
dti-1337	145	6	to	to	PART
dti-1337	145	7	develop	develop	VERB
dti-1337	145	8	new	new	ADJ
dti-1337	145	9	bioreductive	bioreductive	ADJ
dti-1337	145	10	antitumor	antitumor	PROPN
dti-1337	145	11	agents	agent	NOUN
dti-1337	145	12	for	for	ADP
dti-1337	145	13	nqo1	nqo1	PROPN
dti-1337	145	14	targeted	target	VERB
dti-1337	145	15	individualized	individualized	ADJ
dti-1337	145	16	cancer	cancer	NOUN
dti-1337	145	17	chemotherapy	chemotherapy	NOUN
dti-1337	145	18	that	that	PRON
dti-1337	145	19	produce	produce	VERB
dti-1337	145	20	the	the	DET
dti-1337	145	21	optimal	optimal	ADJ
dti-1337	145	22	therapeutic	therapeutic	ADJ
dti-1337	145	23	index	index	NOUN
dti-1337	145	24	for	for	ADP
dti-1337	145	25	each	each	DET
dti-1337	145	26	patient	patient	NOUN
dti-1337	145	27	.	.	PUNCT
dti-1337	146	1	acknowledgments	acknowledgment	NOUN
dti-1337	146	2	this	this	DET
dti-1337	146	3	work	work	NOUN
dti-1337	146	4	was	be	AUX
dti-1337	146	5	supported	support	VERB
dti-1337	146	6	by	by	ADP
dti-1337	146	7	grants	grant	NOUN
dti-1337	146	8	from	from	ADP
dti-1337	146	9	the	the	DET
dti-1337	146	10	cancercare	cancercare	PROPN
dti-1337	146	11	manitoba	manitoba	PROPN
dti-1337	146	12	foundation	foundation	PROPN
dti-1337	146	13	(	(	PUNCT
dti-1337	146	14	ab	ab	PROPN
dti-1337	146	15	)	)	PUNCT
dti-1337	146	16	and	and	CCONJ
dti-1337	146	17	from	from	ADP
dti-1337	146	18	the	the	DET
dti-1337	146	19	herbert	herbert	PROPN
dti-1337	146	20	and	and	CCONJ
dti-1337	146	21	kate	kate	PROPN
dti-1337	146	22	dishman	dishman	PROPN
dti-1337	146	23	endowment	endowment	PROPN
dti-1337	146	24	at	at	ADP
dti-1337	146	25	southwestern	southwestern	ADJ
dti-1337	146	26	university	university	PROPN
dti-1337	146	27	(	(	PUNCT
dti-1337	146	28	fsg	fsg	PROPN
dti-1337	146	29	)	)	PUNCT
dti-1337	146	30	and	and	CCONJ
dti-1337	146	31	the	the	DET
dti-1337	146	32	robert	robert	PROPN
dti-1337	146	33	a.	a.	PROPN
dti-1337	146	34	welch	welch	PROPN
dti-1337	146	35	foundation	foundation	PROPN
dti-1337	146	36	(	(	PUNCT
dti-1337	146	37	grant	grant	PROPN
dti-1337	146	38	af-0005	af-0005	PROPN
dti-1337	146	39	)	)	PUNCT
dti-1337	146	40	(	(	PUNCT
dti-1337	146	41	fsg	fsg	PROPN
dti-1337	146	42	)	)	PUNCT
dti-1337	146	43	.	.	PUNCT
dti-1337	147	1	the	the	DET
dti-1337	147	2	authors	author	NOUN
dti-1337	147	3	thank	thank	VERB
dti-1337	147	4	lindsay	lindsay	PROPN
dti-1337	147	5	jones	jones	PROPN
dti-1337	147	6	for	for	ADP
dti-1337	147	7	technical	technical	ADJ
dti-1337	147	8	assistance	assistance	NOUN
dti-1337	147	9	.	.	PUNCT
dti-1337	148	1	disclosure	disclosure	NOUN
dti-1337	148	2	the	the	DET
dti-1337	148	3	authors	author	NOUN
dti-1337	148	4	report	report	VERB
dti-1337	148	5	no	no	DET
dti-1337	148	6	confl	confl	NOUN
dti-1337	148	7	icts	ict	NOUN
dti-1337	148	8	of	of	ADP
dti-1337	148	9	interest	interest	NOUN
dti-1337	148	10	.	.	PUNCT
dti-1337	149	1	references	reference	NOUN
dti-1337	149	2	1	1	NUM
dti-1337	149	3	.	.	PUNCT
dti-1337	149	4	riley	riley	PROPN
dti-1337	149	5	rj	rj	PROPN
dti-1337	149	6	.	.	PROPN
dti-1337	149	7	,	,	PUNCT
dti-1337	149	8	workman	workman	NOUN
dti-1337	149	9	p.	p.	PROPN
dti-1337	149	10	dt	dt	PROPN
dti-1337	149	11	-	-	PUNCT
dti-1337	149	12	diaphorase	diaphorase	NOUN
dti-1337	149	13	and	and	CCONJ
dti-1337	149	14	cancer	cancer	NOUN
dti-1337	149	15	chemotherapy	chemotherapy	NOUN
dti-1337	149	16	.	.	PUNCT
dti-1337	150	1	biochem	biochem	PROPN
dti-1337	150	2	pharmacol	pharmacol	PROPN
dti-1337	150	3	.	.	PUNCT
dti-1337	151	1	1992;43:1657–69	1992;43:1657–69	NUM
dti-1337	151	2	.	.	X
dti-1337	151	3	2	2	X
dti-1337	151	4	.	.	X
dti-1337	151	5	workman	workman	NOUN
dti-1337	151	6	p.	p.	NOUN
dti-1337	151	7	enzyme	enzyme	NOUN
dti-1337	151	8	-	-	PUNCT
dti-1337	151	9	directed	direct	VERB
dti-1337	151	10	bioreductive	bioreductive	ADJ
dti-1337	151	11	drug	drug	NOUN
dti-1337	151	12	development	development	NOUN
dti-1337	151	13	revisited	revisit	VERB
dti-1337	151	14	:	:	PUNCT
dti-1337	151	15	a	a	DET
dti-1337	151	16	commentary	commentary	NOUN
dti-1337	151	17	on	on	ADP
dti-1337	151	18	recent	recent	ADJ
dti-1337	151	19	progress	progress	NOUN
dti-1337	151	20	and	and	CCONJ
dti-1337	151	21	future	future	ADJ
dti-1337	151	22	prospects	prospect	NOUN
dti-1337	151	23	with	with	ADP
dti-1337	151	24	emphasis	emphasis	NOUN
dti-1337	151	25	on	on	ADP
dti-1337	151	26	quinone	quinone	NOUN
dti-1337	151	27	anticancer	anticancer	NOUN
dti-1337	151	28	agents	agent	NOUN
dti-1337	151	29	and	and	CCONJ
dti-1337	151	30	quinone	quinone	NOUN
dti-1337	151	31	metabolizing	metabolize	VERB
dti-1337	151	32	enzymes	enzyme	NOUN
dti-1337	151	33	,	,	PUNCT
dti-1337	151	34	particularly	particularly	ADV
dti-1337	151	35	dt	dt	NOUN
dti-1337	151	36	-	-	PUNCT
dti-1337	151	37	diaphorase	diaphorase	NOUN
dti-1337	151	38	.	.	PUNCT
dti-1337	152	1	oncol	oncol	ADJ
dti-1337	152	2	res	re	NOUN
dti-1337	152	3	.	.	PUNCT
dti-1337	153	1	1994;6:461–75	1994;6:461–75	X
dti-1337	153	2	.	.	PUNCT
dti-1337	153	3	3	3	X
dti-1337	153	4	.	.	X
dti-1337	153	5	sartorelli	sartorelli	PROPN
dti-1337	153	6	ac	ac	PROPN
dti-1337	153	7	.	.	PUNCT
dti-1337	154	1	therapeutic	therapeutic	ADJ
dti-1337	154	2	attack	attack	NOUN
dti-1337	154	3	of	of	ADP
dti-1337	154	4	hypoxic	hypoxic	ADJ
dti-1337	154	5	cells	cell	NOUN
dti-1337	154	6	of	of	ADP
dti-1337	154	7	solid	solid	ADJ
dti-1337	154	8	tumors	tumor	NOUN
dti-1337	154	9	:	:	PUNCT
dti-1337	154	10	presidential	presidential	ADJ
dti-1337	154	11	address	address	NOUN
dti-1337	154	12	.	.	PUNCT
dti-1337	155	1	cancer	cancer	NOUN
dti-1337	155	2	res	re	NOUN
dti-1337	155	3	.	.	PUNCT
dti-1337	156	1	1988;48:775–8	1988;48:775–8	NUM
dti-1337	156	2	.	.	NOUN
dti-1337	157	1	4	4	X
dti-1337	157	2	.	.	X
dti-1337	157	3	workman	workman	NOUN
dti-1337	157	4	p	p	NOUN
dti-1337	157	5	,	,	PUNCT
dti-1337	157	6	stratford	stratford	PROPN
dti-1337	157	7	ij	ij	NOUN
dti-1337	157	8	.	.	PUNCT
dti-1337	158	1	the	the	DET
dti-1337	158	2	experimental	experimental	ADJ
dti-1337	158	3	development	development	NOUN
dti-1337	158	4	of	of	ADP
dti-1337	158	5	bioreductive	bioreductive	ADJ
dti-1337	158	6	drugs	drug	NOUN
dti-1337	158	7	and	and	CCONJ
dti-1337	158	8	their	their	PRON
dti-1337	158	9	role	role	NOUN
dti-1337	158	10	in	in	ADP
dti-1337	158	11	cancer	cancer	NOUN
dti-1337	158	12	therapy	therapy	NOUN
dti-1337	158	13	.	.	PUNCT
dti-1337	159	1	cancer	cancer	NOUN
dti-1337	159	2	metastasis	metastasis	NOUN
dti-1337	159	3	rev	rev	VERB
dti-1337	159	4	.	.	PROPN
dti-1337	159	5	1993;12:73–82	1993;12:73–82	NUM
dti-1337	159	6	.	.	X
dti-1337	159	7	8	8	NUM
dti-1337	159	8	begleiter	begleiter	NOUN
dti-1337	159	9	et	et	PROPN
dti-1337	159	10	al	al	PROPN
dti-1337	159	11	drug	drug	PROPN
dti-1337	159	12	target	target	NOUN
dti-1337	159	13	insights	insight	NOUN
dti-1337	159	14	2009:4	2009:4	NUM
dti-1337	159	15	5	5	NUM
dti-1337	159	16	.	.	PUNCT
dti-1337	160	1	rockwell	rockwell	PROPN
dti-1337	160	2	s	s	PROPN
dti-1337	160	3	,	,	PUNCT
dti-1337	160	4	sartorelli	sartorelli	PROPN
dti-1337	160	5	ac	ac	PROPN
dti-1337	160	6	,	,	PUNCT
dti-1337	160	7	tomasz	tomasz	PROPN
dti-1337	160	8	m	m	PROPN
dti-1337	160	9	,	,	PUNCT
dti-1337	160	10	kennedy	kennedy	PROPN
dti-1337	160	11	ka	ka	PROPN
dti-1337	160	12	.	.	PROPN
dti-1337	160	13	cellular	cellular	ADJ
dti-1337	160	14	pharmacology	pharmacology	NOUN
dti-1337	160	15	of	of	ADP
dti-1337	160	16	quinone	quinone	NOUN
dti-1337	160	17	bioreductive	bioreductive	ADJ
dti-1337	160	18	alkylating	alkylate	VERB
dti-1337	160	19	agents	agent	NOUN
dti-1337	160	20	.	.	PUNCT
dti-1337	161	1	cancer	cancer	NOUN
dti-1337	161	2	metastasis	metastasis	NOUN
dti-1337	161	3	rev	rev	VERB
dti-1337	161	4	.	.	PUNCT
dti-1337	162	1	1993;12:165–76	1993;12:165–76	NUM
dti-1337	162	2	.	.	NOUN
dti-1337	163	1	6	6	NUM
dti-1337	163	2	.	.	X
dti-1337	163	3	rauth	rauth	PROPN
dti-1337	163	4	am	be	AUX
dti-1337	163	5	,	,	PUNCT
dti-1337	163	6	marshall	marshall	PROPN
dti-1337	163	7	rs	rs	PROPN
dti-1337	163	8	,	,	PUNCT
dti-1337	163	9	kuehl	kuehl	PROPN
dti-1337	163	10	bl	bl	PROPN
dti-1337	163	11	.	.	PUNCT
dti-1337	164	1	cellular	cellular	ADJ
dti-1337	164	2	approaches	approach	NOUN
dti-1337	164	3	to	to	ADP
dti-1337	164	4	bioreductive	bioreductive	ADJ
dti-1337	164	5	drug	drug	NOUN
dti-1337	164	6	mechanisms	mechanism	NOUN
dti-1337	164	7	.	.	PUNCT
dti-1337	165	1	cancer	cancer	NOUN
dti-1337	165	2	metastasis	metastasis	NOUN
dti-1337	165	3	rev	rev	VERB
dti-1337	165	4	.	.	PUNCT
dti-1337	166	1	1993;12:153–64	1993;12:153–64	PROPN
dti-1337	166	2	.	.	PUNCT
dti-1337	167	1	7	7	NUM
dti-1337	167	2	.	.	X
dti-1337	167	3	begleiter	begleiter	PROPN
dti-1337	167	4	a.	a.	PROPN
dti-1337	167	5	clinical	clinical	PROPN
dti-1337	167	6	applications	application	NOUN
dti-1337	167	7	of	of	ADP
dti-1337	167	8	quinone	quinone	NOUN
dti-1337	167	9	alkylating	alkylating	NOUN
dti-1337	167	10	agents	agent	NOUN
dti-1337	167	11	.	.	PUNCT
dti-1337	168	1	frontiers	frontier	NOUN
dti-1337	168	2	bioscience	bioscience	NOUN
dti-1337	168	3	.	.	PUNCT
dti-1337	169	1	2000;5	2000;5	NUM
dti-1337	169	2	:	:	PUNCT
dti-1337	169	3	e153–71	e153–71	NOUN
dti-1337	169	4	.	.	PUNCT
dti-1337	170	1	8	8	X
dti-1337	170	2	.	.	PUNCT
dti-1337	171	1	rockwell	rockwell	PROPN
dti-1337	171	2	s	s	PROPN
dti-1337	171	3	,	,	PUNCT
dti-1337	171	4	keyes	keyes	PROPN
dti-1337	171	5	sr	sr	PROPN
dti-1337	171	6	,	,	PUNCT
dti-1337	171	7	sartorelli	sartorelli	PROPN
dti-1337	171	8	ac	ac	PROPN
dti-1337	171	9	.	.	PUNCT
dti-1337	172	1	preclinical	preclinical	ADJ
dti-1337	172	2	studies	study	NOUN
dti-1337	172	3	of	of	ADP
dti-1337	172	4	porfi	porfi	VERB
dti-1337	172	5	romycin	romycin	VERB
dti-1337	172	6	as	as	ADP
dti-1337	172	7	an	an	DET
dti-1337	172	8	adjunct	adjunct	ADJ
dti-1337	172	9	to	to	PART
dti-1337	172	10	radiotherapy	radiotherapy	VERB
dti-1337	172	11	.	.	PUNCT
dti-1337	173	1	radiat	radiat	PROPN
dti-1337	173	2	.	.	PUNCT
dti-1337	174	1	res	re	NOUN
dti-1337	174	2	.	.	PUNCT
dti-1337	175	1	1988;116:100–13	1988;116:100–13	NUM
dti-1337	175	2	.	.	NOUN
dti-1337	175	3	9	9	NUM
dti-1337	175	4	.	.	PUNCT
dti-1337	176	1	chamberlain	chamberlain	PROPN
dti-1337	176	2	mc	mc	PROPN
dti-1337	176	3	,	,	PUNCT
dti-1337	176	4	prados	prados	PROPN
dti-1337	176	5	md	md	PROPN
dti-1337	176	6	,	,	PUNCT
dti-1337	176	7	silver	silver	NOUN
dti-1337	176	8	p	p	NOUN
dti-1337	176	9	,	,	PUNCT
dti-1337	176	10	levin	levin	PROPN
dti-1337	176	11	va	va	PROPN
dti-1337	176	12	.	.	PUNCT
dti-1337	177	1	a	a	DET
dti-1337	177	2	phase	phase	NOUN
dti-1337	177	3	i	i	PRON
dti-1337	177	4	/	/	SYM
dti-1337	177	5	ii	ii	PROPN
dti-1337	177	6	study	study	NOUN
dti-1337	177	7	of	of	ADP
dti-1337	177	8	24	24	NUM
dti-1337	177	9	hour	hour	NOUN
dti-1337	177	10	intravenous	intravenous	ADJ
dti-1337	177	11	azq	azq	PROPN
dti-1337	177	12	.	.	PUNCT
dti-1337	178	1	in	in	ADP
dti-1337	178	2	recurrent	recurrent	ADJ
dti-1337	178	3	primary	primary	ADJ
dti-1337	178	4	brain	brain	NOUN
dti-1337	178	5	tumors	tumor	NOUN
dti-1337	178	6	.	.	PUNCT
dti-1337	179	1	j	j	PROPN
dti-1337	179	2	neurooncol	neurooncol	PROPN
dti-1337	179	3	.	.	PUNCT
dti-1337	180	1	1988;6:319–23	1988;6:319–23	NUM
dti-1337	180	2	.	.	PROPN
dti-1337	181	1	10	10	NUM
dti-1337	181	2	.	.	PUNCT
dti-1337	182	1	schellens	schellen	VERB
dti-1337	182	2	jhm	jhm	PROPN
dti-1337	182	3	,	,	PUNCT
dti-1337	182	4	planting	planting	NOUN
dti-1337	182	5	ast	ast	NOUN
dti-1337	182	6	,	,	PUNCT
dti-1337	182	7	van	van	PROPN
dti-1337	182	8	acker	acker	PROPN
dti-1337	182	9	bac	bac	PROPN
dti-1337	182	10	,	,	PUNCT
dti-1337	183	1	et	et	PROPN
dti-1337	183	2	al	al	PROPN
dti-1337	183	3	.	.	PROPN
dti-1337	183	4	phase	phase	NOUN
dti-1337	183	5	i	i	PRON
dti-1337	183	6	and	and	CCONJ
dti-1337	183	7	pharmacologic	pharmacologic	ADJ
dti-1337	183	8	study	study	NOUN
dti-1337	183	9	of	of	ADP
dti-1337	183	10	the	the	DET
dti-1337	183	11	novel	novel	ADJ
dti-1337	183	12	indoloquinone	indoloquinone	NOUN
dti-1337	183	13	bioreductive	bioreductive	ADJ
dti-1337	183	14	alkylating	alkylate	VERB
dti-1337	183	15	cytotoxic	cytotoxic	ADJ
dti-1337	183	16	drug	drug	NOUN
dti-1337	183	17	e09	e09	PROPN
dti-1337	183	18	.	.	PUNCT
dti-1337	184	1	j	j	PROPN
dti-1337	184	2	natl	natl	PROPN
dti-1337	184	3	cancer	cancer	PROPN
dti-1337	184	4	inst	inst	PROPN
dti-1337	184	5	.	.	PUNCT
dti-1337	185	1	1994;86:906–12	1994;86:906–12	NUM
dti-1337	185	2	.	.	PROPN
dti-1337	185	3	11	11	NUM
dti-1337	185	4	.	.	X
dti-1337	185	5	dirix	dirix	PROPN
dti-1337	185	6	ly	ly	PROPN
dti-1337	185	7	,	,	PUNCT
dti-1337	185	8	tonnesen	tonnesen	VERB
dti-1337	185	9	f	f	PROPN
dti-1337	185	10	,	,	PUNCT
dti-1337	185	11	cassidy	cassidy	PROPN
dti-1337	185	12	j	j	PROPN
dti-1337	185	13	,	,	PUNCT
dti-1337	185	14	et	et	PROPN
dti-1337	185	15	al	al	PROPN
dti-1337	185	16	.	.	PROPN
dti-1337	185	17	eo9	eo9	PROPN
dti-1337	185	18	phase	phase	PROPN
dti-1337	185	19	ii	ii	PROPN
dti-1337	185	20	study	study	NOUN
dti-1337	185	21	in	in	ADP
dti-1337	185	22	advanced	advanced	ADJ
dti-1337	185	23	breast	breast	NOUN
dti-1337	185	24	,	,	PUNCT
dti-1337	185	25	gastric	gastric	ADJ
dti-1337	185	26	,	,	PUNCT
dti-1337	185	27	pancreatic	pancreatic	ADJ
dti-1337	185	28	and	and	CCONJ
dti-1337	185	29	colorectal	colorectal	ADJ
dti-1337	185	30	carcinoma	carcinoma	NOUN
dti-1337	185	31	by	by	ADP
dti-1337	185	32	the	the	DET
dti-1337	185	33	eortc	eortc	ADJ
dti-1337	185	34	early	early	ADJ
dti-1337	185	35	clinical	clinical	ADJ
dti-1337	185	36	studies	study	NOUN
dti-1337	185	37	group	group	NOUN
dti-1337	185	38	.	.	PUNCT
dti-1337	186	1	eur	eur	PROPN
dti-1337	186	2	j	j	PROPN
dti-1337	186	3	cancer	cancer	NOUN
dti-1337	187	1	[	[	X
dti-1337	187	2	a	a	X
dti-1337	187	3	]	]	X
dti-1337	187	4	.	.	PUNCT
dti-1337	188	1	1996;32a:2019–22	1996;32a:2019–22	PROPN
dti-1337	188	2	.	.	PUNCT
dti-1337	189	1	12	12	NUM
dti-1337	189	2	.	.	PUNCT
dti-1337	190	1	senan	senan	PROPN
dti-1337	190	2	s	s	PART
dti-1337	190	3	,	,	PUNCT
dti-1337	190	4	rampling	rample	VERB
dti-1337	190	5	r	r	PROPN
dti-1337	190	6	,	,	PUNCT
dti-1337	190	7	graham	graham	PROPN
dti-1337	190	8	ma	ma	PROPN
dti-1337	190	9	,	,	PUNCT
dti-1337	190	10	et	et	PROPN
dti-1337	190	11	al	al	PROPN
dti-1337	190	12	.	.	PROPN
dti-1337	190	13	phase	phase	NOUN
dti-1337	190	14	i	i	PRON
dti-1337	190	15	and	and	CCONJ
dti-1337	190	16	pharmacokinetic	pharmacokinetic	ADJ
dti-1337	190	17	study	study	NOUN
dti-1337	190	18	of	of	ADP
dti-1337	190	19	tirapazamine	tirapazamine	PROPN
dti-1337	190	20	(	(	PUNCT
dti-1337	190	21	sr	sr	PROPN
dti-1337	190	22	.	.	PROPN
dti-1337	190	23	4233	4233	NUM
dti-1337	190	24	)	)	PUNCT
dti-1337	190	25	administered	administer	VERB
dti-1337	190	26	every	every	DET
dti-1337	190	27	three	three	NUM
dti-1337	190	28	weeks	week	NOUN
dti-1337	190	29	.	.	PUNCT
dti-1337	191	1	clin	clin	PROPN
dti-1337	191	2	cancer	cancer	NOUN
dti-1337	191	3	res	re	NOUN
dti-1337	191	4	.	.	PUNCT
dti-1337	192	1	1997;3:31–8	1997;3:31–8	NUM
dti-1337	192	2	.	.	PUNCT
dti-1337	193	1	13	13	NUM
dti-1337	193	2	.	.	PUNCT
dti-1337	194	1	lee	lee	PROPN
dti-1337	194	2	dj	dj	PROPN
dti-1337	194	3	,	,	PUNCT
dti-1337	194	4	trotti	trotti	NOUN
dti-1337	194	5	a	a	X
dti-1337	194	6	,	,	PUNCT
dti-1337	194	7	spencer	spencer	PROPN
dti-1337	194	8	s	s	PROPN
dti-1337	194	9	,	,	PUNCT
dti-1337	194	10	et	et	PROPN
dti-1337	194	11	al	al	PROPN
dti-1337	194	12	.	.	PUNCT
dti-1337	195	1	concurrent	concurrent	PROPN
dti-1337	195	2	tirapazamine	tirapazamine	PROPN
dti-1337	195	3	and	and	CCONJ
dti-1337	195	4	radiotherapy	radiotherapy	NOUN
dti-1337	195	5	for	for	ADP
dti-1337	195	6	advanced	advanced	ADJ
dti-1337	195	7	head	head	NOUN
dti-1337	195	8	and	and	CCONJ
dti-1337	195	9	neck	neck	NOUN
dti-1337	195	10	carcinomas	carcinoma	NOUN
dti-1337	195	11	:	:	PUNCT
dti-1337	195	12	a	a	DET
dti-1337	195	13	phase	phase	NOUN
dti-1337	195	14	ii	ii	NOUN
dti-1337	195	15	study	study	NOUN
dti-1337	195	16	.	.	PUNCT
dti-1337	196	1	int	int	PROPN
dti-1337	196	2	j	j	PROPN
dti-1337	196	3	radiat	radiat	PROPN
dti-1337	196	4	oncol	oncol	ADJ
dti-1337	196	5	biol	biol	PROPN
dti-1337	196	6	phys	phy	NOUN
dti-1337	196	7	.	.	PUNCT
dti-1337	197	1	1998;42:811–5	1998;42:811–5	NUM
dti-1337	197	2	.	.	PUNCT
dti-1337	198	1	14	14	NUM
dti-1337	198	2	.	.	PUNCT
dti-1337	199	1	winski	winski	PROPN
dti-1337	199	2	sl	sl	PROPN
dti-1337	199	3	,	,	PUNCT
dti-1337	199	4	hargreaves	hargreaves	PROPN
dti-1337	199	5	rh	rh	PROPN
dti-1337	199	6	,	,	PUNCT
dti-1337	199	7	butler	butler	PROPN
dti-1337	199	8	j	j	PROPN
dti-1337	199	9	,	,	PUNCT
dti-1337	199	10	ross	ross	PROPN
dti-1337	199	11	d.	d.	PROPN
dti-1337	199	12	a	a	DET
dti-1337	199	13	new	new	ADJ
dti-1337	199	14	screening	screening	NOUN
dti-1337	199	15	system	system	NOUN
dti-1337	199	16	for	for	ADP
dti-1337	199	17	nad(p)h	nad(p)h	NOUN
dti-1337	199	18	:	:	PUNCT
dti-1337	199	19	quinone	quinone	NOUN
dti-1337	199	20	oxidoreductase	oxidoreductase	NOUN
dti-1337	199	21	(	(	PUNCT
dti-1337	199	22	nqo1)-directed	nqo1)-directed	ADJ
dti-1337	199	23	antitumor	antitumor	PROPN
dti-1337	199	24	quinones	quinone	NOUN
dti-1337	199	25	:	:	PUNCT
dti-1337	199	26	identifi	identifi	PROPN
dti-1337	199	27	cation	cation	NOUN
dti-1337	199	28	of	of	ADP
dti-1337	199	29	a	a	DET
dti-1337	199	30	new	new	ADJ
dti-1337	199	31	aziridinylbenzoquinone	aziridinylbenzoquinone	NOUN
dti-1337	199	32	,	,	PUNCT
dti-1337	199	33	rh1	rh1	NOUN
dti-1337	199	34	,	,	PUNCT
dti-1337	199	35	as	as	ADP
dti-1337	199	36	a	a	DET
dti-1337	199	37	nqo1	nqo1	NOUN
dti-1337	199	38	-	-	PUNCT
dti-1337	199	39	directed	direct	VERB
dti-1337	199	40	antitumor	antitumor	PROPN
dti-1337	199	41	agent	agent	NOUN
dti-1337	199	42	.	.	PUNCT
dti-1337	200	1	clin	clin	PROPN
dti-1337	200	2	.	.	PUNCT
dti-1337	201	1	cancer	cancer	NOUN
dti-1337	201	2	res	re	NOUN
dti-1337	201	3	.	.	PUNCT
dti-1337	202	1	1998;4:3083–8	1998;4:3083–8	NUM
dti-1337	202	2	.	.	NOUN
dti-1337	203	1	15	15	NUM
dti-1337	203	2	.	.	PUNCT
dti-1337	204	1	loadman	loadman	PROPN
dti-1337	204	2	pm	pm	PROPN
dti-1337	204	3	,	,	PUNCT
dti-1337	204	4	phillips	phillips	PROPN
dti-1337	204	5	rm	rm	PROPN
dti-1337	204	6	,	,	PUNCT
dti-1337	204	7	lim	lim	PROPN
dti-1337	204	8	le	le	PROPN
dti-1337	204	9	,	,	PUNCT
dti-1337	204	10	bibby	bibby	PROPN
dti-1337	204	11	mc	mc	PROPN
dti-1337	204	12	.	.	PROPN
dti-1337	204	13	pharmacological	pharmacological	ADJ
dti-1337	204	14	properties	property	NOUN
dti-1337	204	15	of	of	ADP
dti-1337	204	16	a	a	DET
dti-1337	204	17	new	new	ADJ
dti-1337	204	18	aziridinylbenzoquinone	aziridinylbenzoquinone	NOUN
dti-1337	204	19	,	,	PUNCT
dti-1337	204	20	rh1	rh1	X
dti-1337	204	21	(	(	PUNCT
dti-1337	204	22	2,5	2,5	NUM
dti-1337	204	23	-	-	PUNCT
dti-1337	204	24	diaziridinyl-3(hydroxymethyl)-6	diaziridinyl-3(hydroxymethyl)-6	ADP
dti-1337	204	25	-	-	PUNCT
dti-1337	204	26	methyl-1,4	methyl-1,4	NOUN
dti-1337	204	27	-	-	PUNCT
dti-1337	204	28	benzoquinone	benzoquinone	NOUN
dti-1337	204	29	)	)	PUNCT
dti-1337	204	30	,	,	PUNCT
dti-1337	204	31	in	in	ADP
dti-1337	204	32	mice	mouse	NOUN
dti-1337	204	33	.	.	PUNCT
dti-1337	205	1	biochem	biochem	PROPN
dti-1337	205	2	pharmacol	pharmacol	PROPN
dti-1337	205	3	.	.	PUNCT
dti-1337	206	1	2000;59:831–7	2000;59:831–7	NUM
dti-1337	206	2	.	.	PUNCT
dti-1337	207	1	16	16	NUM
dti-1337	207	2	.	.	PUNCT
dti-1337	208	1	loadman	loadman	PROPN
dti-1337	208	2	pm	pm	PROPN
dti-1337	208	3	,	,	PUNCT
dti-1337	208	4	bibby	bibby	PROPN
dti-1337	208	5	mc	mc	PROPN
dti-1337	208	6	,	,	PUNCT
dti-1337	208	7	phillips	phillips	PROPN
dti-1337	208	8	rm	rm	PROPN
dti-1337	208	9	.	.	PUNCT
dti-1337	208	10	pharmacological	pharmacological	ADJ
dti-1337	208	11	approach	approach	NOUN
dti-1337	208	12	towards	towards	ADP
dti-1337	208	13	the	the	DET
dti-1337	208	14	development	development	NOUN
dti-1337	208	15	of	of	ADP
dti-1337	208	16	indolequinone	indolequinone	NOUN
dti-1337	208	17	bioreductive	bioreductive	ADJ
dti-1337	208	18	drugs	drug	NOUN
dti-1337	208	19	based	base	VERB
dti-1337	208	20	on	on	ADP
dti-1337	208	21	the	the	DET
dti-1337	208	22	clinically	clinically	ADV
dti-1337	208	23	inactive	inactive	ADJ
dti-1337	208	24	agent	agent	NOUN
dti-1337	208	25	eo9	eo9	NOUN
dti-1337	208	26	.	.	PUNCT
dti-1337	209	1	br	br	PROPN
dti-1337	209	2	j	j	PROPN
dti-1337	209	3	pharmacol	pharmacol	PROPN
dti-1337	209	4	.	.	PUNCT
dti-1337	210	1	2002;137:701–9	2002;137:701–9	NUM
dti-1337	210	2	.	.	PROPN
dti-1337	211	1	17	17	NUM
dti-1337	211	2	.	.	PUNCT
dti-1337	212	1	jaffar	jaffar	PROPN
dti-1337	212	2	m	m	PROPN
dti-1337	212	3	,	,	PUNCT
dti-1337	212	4	phillips	phillips	PROPN
dti-1337	212	5	rm	rm	PROPN
dti-1337	212	6	,	,	PUNCT
dti-1337	212	7	williams	williams	PROPN
dti-1337	212	8	kj	kj	PROPN
dti-1337	212	9	,	,	PUNCT
dti-1337	212	10	et	et	PROPN
dti-1337	212	11	al	al	PROPN
dti-1337	212	12	.	.	PROPN
dti-1337	212	13	3	3	NUM
dti-1337	212	14	-	-	PUNCT
dti-1337	212	15	substituted-5	substituted-5	NUM
dti-1337	212	16	-	-	PUNCT
dti-1337	212	17	aziridinyl1	aziridinyl1	NOUN
dti-1337	212	18	-	-	PUNCT
dti-1337	212	19	methylindole-4,7	methylindole-4,7	NOUN
dti-1337	212	20	-	-	PUNCT
dti-1337	212	21	diones	dione	NOUN
dti-1337	212	22	as	as	ADP
dti-1337	212	23	nqo1	nqo1	NOUN
dti-1337	212	24	-	-	PUNCT
dti-1337	212	25	directed	direct	VERB
dti-1337	212	26	antitumour	antitumour	NOUN
dti-1337	212	27	agents	agent	NOUN
dti-1337	212	28	:	:	PUNCT
dti-1337	212	29	mechanism	mechanism	NOUN
dti-1337	212	30	of	of	ADP
dti-1337	212	31	activation	activation	NOUN
dti-1337	212	32	and	and	CCONJ
dti-1337	212	33	cytotoxicity	cytotoxicity	NOUN
dti-1337	212	34	in	in	ADP
dti-1337	212	35	vitro	vitro	X
dti-1337	212	36	.	.	PUNCT
dti-1337	213	1	biochem	biochem	PROPN
dti-1337	213	2	pharmacol	pharmacol	PROPN
dti-1337	213	3	.	.	PUNCT
dti-1337	214	1	2003;66:1199–206	2003;66:1199–206	X
dti-1337	214	2	.	.	NOUN
dti-1337	214	3	18	18	NUM
dti-1337	214	4	.	.	PUNCT
dti-1337	215	1	hortobagyi	hortobagyi	PROPN
dti-1337	215	2	gn	gn	PROPN
dti-1337	215	3	.	.	PROPN
dti-1337	215	4	mitomycin	mitomycin	PROPN
dti-1337	215	5	:	:	PUNCT
dti-1337	215	6	its	its	PRON
dti-1337	215	7	evolving	evolve	VERB
dti-1337	215	8	role	role	NOUN
dti-1337	215	9	in	in	ADP
dti-1337	215	10	the	the	DET
dti-1337	215	11	treatment	treatment	NOUN
dti-1337	215	12	of	of	ADP
dti-1337	215	13	breast	breast	NOUN
dti-1337	215	14	cancer	cancer	NOUN
dti-1337	215	15	.	.	PUNCT
dti-1337	216	1	oncology	oncology	NOUN
dti-1337	216	2	(	(	PUNCT
dti-1337	216	3	basel	basel	PROPN
dti-1337	216	4	)	)	PUNCT
dti-1337	216	5	.	.	PUNCT
dti-1337	217	1	1993;50	1993;50	NUM
dti-1337	217	2	suppl	suppl	ADJ
dti-1337	217	3	1:1–8	1:1–8	NUM
dti-1337	217	4	.	.	PROPN
dti-1337	218	1	19	19	NUM
dti-1337	218	2	.	.	PUNCT
dti-1337	218	3	digby	digby	PROPN
dti-1337	218	4	t	t	PROPN
dti-1337	218	5	,	,	PUNCT
dti-1337	218	6	leith	leith	PROPN
dti-1337	218	7	mk	mk	PROPN
dti-1337	218	8	,	,	PUNCT
dti-1337	218	9	thliveris	thliveris	PROPN
dti-1337	218	10	ja	ja	PROPN
dti-1337	218	11	,	,	PUNCT
dti-1337	218	12	begleiter	begleiter	NOUN
dti-1337	218	13	a.	a.	NOUN
dti-1337	218	14	effect	effect	NOUN
dti-1337	218	15	of	of	ADP
dti-1337	218	16	nqo1	nqo1	PROPN
dti-1337	218	17	induction	induction	NOUN
dti-1337	218	18	on	on	ADP
dti-1337	218	19	the	the	DET
dti-1337	218	20	antitumor	antitumor	PROPN
dti-1337	218	21	activity	activity	NOUN
dti-1337	218	22	of	of	ADP
dti-1337	218	23	rh1	rh1	NOUN
dti-1337	218	24	in	in	ADP
dti-1337	218	25	human	human	ADJ
dti-1337	218	26	tumors	tumor	NOUN
dti-1337	218	27	in	in	ADP
dti-1337	218	28	vitro	vitro	X
dti-1337	218	29	and	and	CCONJ
dti-1337	218	30	in	in	ADP
dti-1337	218	31	vivo	vivo	NOUN
dti-1337	218	32	.	.	PUNCT
dti-1337	219	1	cancer	cancer	NOUN
dti-1337	219	2	chemother	chemother	PROPN
dti-1337	219	3	pharmacol	pharmacol	PROPN
dti-1337	219	4	.	.	PUNCT
dti-1337	220	1	2005;56:307–16	2005;56:307–16	X
dti-1337	220	2	.	.	PROPN
dti-1337	220	3	20	20	NUM
dti-1337	220	4	.	.	PUNCT
dti-1337	221	1	ross	ross	PROPN
dti-1337	221	2	d	d	PROPN
dti-1337	221	3	,	,	PUNCT
dti-1337	221	4	siegel	siegel	PROPN
dti-1337	221	5	d	d	PROPN
dti-1337	221	6	,	,	PUNCT
dti-1337	221	7	beall	beall	PROPN
dti-1337	221	8	h	h	PROPN
dti-1337	221	9	,	,	PUNCT
dti-1337	221	10	prakash	prakash	PROPN
dti-1337	221	11	as	as	ADP
dti-1337	221	12	,	,	PUNCT
dti-1337	221	13	mulcahy	mulcahy	PROPN
dti-1337	221	14	rt	rt	PROPN
dti-1337	221	15	,	,	PUNCT
dti-1337	221	16	gibson	gibson	PROPN
dti-1337	221	17	nw	nw	PROPN
dti-1337	221	18	.	.	PUNCT
dti-1337	221	19	dt	dt	PROPN
dti-1337	221	20	-	-	PUNCT
dti-1337	221	21	diaphorase	diaphorase	NOUN
dti-1337	221	22	in	in	ADP
dti-1337	221	23	activation	activation	NOUN
dti-1337	221	24	and	and	CCONJ
dti-1337	221	25	detoxifi	detoxifi	VERB
dti-1337	221	26	cation	cation	NOUN
dti-1337	221	27	of	of	ADP
dti-1337	221	28	quinones	quinone	NOUN
dti-1337	221	29	.	.	PUNCT
dti-1337	222	1	cancer	cancer	NOUN
dti-1337	222	2	metastasis	metastasis	NOUN
dti-1337	222	3	rev	rev	VERB
dti-1337	222	4	.	.	PUNCT
dti-1337	223	1	1993;12:83–101	1993;12:83–101	NUM
dti-1337	223	2	.	.	PUNCT
dti-1337	224	1	21	21	NUM
dti-1337	224	2	.	.	PUNCT
dti-1337	225	1	pan	pan	PROPN
dti-1337	225	2	ss	ss	PROPN
dti-1337	225	3	,	,	PUNCT
dti-1337	225	4	andrews	andrews	PROPN
dti-1337	225	5	pa	pa	PROPN
dti-1337	225	6	,	,	PUNCT
dti-1337	225	7	glover	glover	PROPN
dti-1337	225	8	cj	cj	PROPN
dti-1337	225	9	,	,	PUNCT
dti-1337	225	10	bachur	bachur	PROPN
dti-1337	225	11	nr	nr	PROPN
dti-1337	225	12	.	.	PROPN
dti-1337	225	13	reductive	reductive	ADJ
dti-1337	225	14	activation	activation	NOUN
dti-1337	225	15	of	of	ADP
dti-1337	225	16	mitomycin	mitomycin	NOUN
dti-1337	225	17	c	c	PROPN
dti-1337	225	18	and	and	CCONJ
dti-1337	225	19	mitomycin	mitomycin	PROPN
dti-1337	225	20	c	c	PROPN
dti-1337	225	21	metabolites	metabolite	NOUN
dti-1337	225	22	catalyzed	catalyze	VERB
dti-1337	225	23	by	by	ADP
dti-1337	225	24	nadphcytochrome	nadphcytochrome	PROPN
dti-1337	225	25	p-450	p-450	PROPN
dti-1337	225	26	reductase	reductase	NOUN
dti-1337	225	27	and	and	CCONJ
dti-1337	225	28	xanthine	xanthine	NOUN
dti-1337	225	29	oxidase	oxidase	PROPN
dti-1337	225	30	.	.	PUNCT
dti-1337	226	1	j	j	PROPN
dti-1337	226	2	biol	biol	PROPN
dti-1337	226	3	chem	chem	NOUN
dti-1337	226	4	.	.	PUNCT
dti-1337	227	1	1984;259:959–66	1984;259:959–66	ADJ
dti-1337	227	2	.	.	PUNCT
dti-1337	228	1	22	22	NUM
dti-1337	228	2	.	.	PUNCT
dti-1337	229	1	jaiswal	jaiswal	PROPN
dti-1337	229	2	ak	ak	PROPN
dti-1337	229	3	.	.	PROPN
dti-1337	229	4	human	human	PROPN
dti-1337	229	5	nad(p)h	nad(p)h	PROPN
dti-1337	229	6	:	:	PUNCT
dti-1337	229	7	quinone	quinone	NOUN
dti-1337	229	8	oxidoreductase	oxidoreductase	NOUN
dti-1337	229	9	(	(	PUNCT
dti-1337	229	10	nqo-1	nqo-1	NOUN
dti-1337	229	11	)	)	PUNCT
dti-1337	229	12	gene	gene	NOUN
dti-1337	229	13	structure	structure	NOUN
dti-1337	229	14	and	and	CCONJ
dti-1337	229	15	induction	induction	NOUN
dti-1337	229	16	by	by	ADP
dti-1337	229	17	dioxin	dioxin	NOUN
dti-1337	229	18	.	.	PUNCT
dti-1337	230	1	biochemistry	biochemistry	NOUN
dti-1337	230	2	.	.	PUNCT
dti-1337	231	1	1991;30:10647–53	1991;30:10647–53	NUM
dti-1337	231	2	.	.	PUNCT
dti-1337	232	1	23	23	NUM
dti-1337	232	2	.	.	PUNCT
dti-1337	233	1	jaiswal	jaiswal	PROPN
dti-1337	233	2	ak	ak	PROPN
dti-1337	233	3	,	,	PUNCT
dti-1337	233	4	burnett	burnett	PROPN
dti-1337	233	5	p	p	PROPN
dti-1337	233	6	,	,	PUNCT
dti-1337	233	7	adesnick	adesnick	PROPN
dti-1337	233	8	m	m	PROPN
dti-1337	233	9	,	,	PUNCT
dti-1337	233	10	mcbride	mcbride	PROPN
dti-1337	233	11	ow	ow	PROPN
dti-1337	233	12	.	.	PROPN
dti-1337	233	13	nucleotide	nucleotide	NOUN
dti-1337	233	14	and	and	CCONJ
dti-1337	233	15	deduced	deduce	VERB
dti-1337	233	16	amino	amino	NOUN
dti-1337	233	17	acid	acid	NOUN
dti-1337	233	18	sequence	sequence	NOUN
dti-1337	233	19	of	of	ADP
dti-1337	233	20	a	a	DET
dti-1337	233	21	human	human	ADJ
dti-1337	233	22	cdna	cdna	PROPN
dti-1337	233	23	(	(	PUNCT
dti-1337	233	24	nqo2	nqo2	PROPN
dti-1337	233	25	)	)	PUNCT
dti-1337	233	26	corresponding	correspond	VERB
dti-1337	233	27	to	to	ADP
dti-1337	233	28	a	a	DET
dti-1337	233	29	second	second	ADJ
dti-1337	233	30	member	member	NOUN
dti-1337	233	31	of	of	ADP
dti-1337	233	32	the	the	DET
dti-1337	233	33	nad(p)h	nad(p)h	NOUN
dti-1337	233	34	:	:	PUNCT
dti-1337	233	35	quinone	quinone	NOUN
dti-1337	233	36	oxidoreductase	oxidoreductase	NOUN
dti-1337	233	37	gene	gene	NOUN
dti-1337	233	38	family	family	NOUN
dti-1337	233	39	.	.	PUNCT
dti-1337	234	1	extensive	extensive	ADJ
dti-1337	234	2	polymorphism	polymorphism	NOUN
dti-1337	234	3	at	at	ADP
dti-1337	234	4	the	the	DET
dti-1337	234	5	nqo2	nqo2	PROPN
dti-1337	234	6	gene	gene	NOUN
dti-1337	234	7	locus	locus	NOUN
dti-1337	234	8	on	on	ADP
dti-1337	234	9	chromosome	chromosome	NOUN
dti-1337	234	10	6	6	NUM
dti-1337	234	11	.	.	PUNCT
dti-1337	235	1	biochemistry	biochemistry	NOUN
dti-1337	235	2	.	.	PUNCT
dti-1337	236	1	1990;29:1899–906	1990;29:1899–906	NUM
dti-1337	236	2	.	.	NOUN
dti-1337	236	3	24	24	NUM
dti-1337	236	4	.	.	PUNCT
dti-1337	237	1	belinsky	belinsky	PROPN
dti-1337	237	2	m	m	PROPN
dti-1337	237	3	,	,	PUNCT
dti-1337	237	4	jaiswal	jaiswal	PROPN
dti-1337	237	5	ak	ak	PROPN
dti-1337	237	6	.	.	PROPN
dti-1337	237	7	nad(p)h	nad(p)h	PROPN
dti-1337	237	8	:	:	PUNCT
dti-1337	237	9	quinone	quinone	NOUN
dti-1337	237	10	oxidoreductase1	oxidoreductase1	NOUN
dti-1337	237	11	(	(	PUNCT
dti-1337	237	12	dt	dt	NOUN
dti-1337	237	13	-	-	PUNCT
dti-1337	237	14	diaphorase	diaphorase	NOUN
dti-1337	237	15	)	)	PUNCT
dti-1337	237	16	expression	expression	NOUN
dti-1337	237	17	in	in	ADP
dti-1337	237	18	normal	normal	ADJ
dti-1337	237	19	and	and	CCONJ
dti-1337	237	20	tumor	tumor	NOUN
dti-1337	237	21	tissues	tissue	NOUN
dti-1337	237	22	.	.	PUNCT
dti-1337	238	1	cancer	cancer	NOUN
dti-1337	238	2	metastasis	metastasis	NOUN
dti-1337	238	3	rev	rev	VERB
dti-1337	238	4	.	.	PUNCT
dti-1337	239	1	1993;12:103–17	1993;12:103–17	NUM
dti-1337	239	2	.	.	PUNCT
dti-1337	240	1	25	25	NUM
dti-1337	240	2	.	.	PUNCT
dti-1337	241	1	winski	winski	PROPN
dti-1337	241	2	sl	sl	PROPN
dti-1337	241	3	,	,	PUNCT
dti-1337	241	4	koutalos	koutalos	PROPN
dti-1337	241	5	y.	y.	PROPN
dti-1337	241	6	,	,	PUNCT
dti-1337	241	7	bentley	bentley	PROPN
dti-1337	241	8	dl	dl	PROPN
dti-1337	241	9	,	,	PUNCT
dti-1337	241	10	ross	ross	PROPN
dti-1337	241	11	d.	d.	PROPN
dti-1337	241	12	subcellular	subcellular	ADJ
dti-1337	241	13	localization	localization	NOUN
dti-1337	241	14	of	of	ADP
dti-1337	241	15	nad(p)h	nad(p)h	NOUN
dti-1337	241	16	:	:	PUNCT
dti-1337	241	17	quinone	quinone	NOUN
dti-1337	241	18	oxidoreductase	oxidoreductase	NOUN
dti-1337	241	19	1	1	NUM
dti-1337	241	20	in	in	ADP
dti-1337	241	21	human	human	ADJ
dti-1337	241	22	cancer	cancer	NOUN
dti-1337	241	23	cells	cell	NOUN
dti-1337	241	24	.	.	PUNCT
dti-1337	242	1	cancer	cancer	NOUN
dti-1337	242	2	res	re	NOUN
dti-1337	242	3	.	.	PUNCT
dti-1337	243	1	2002;62:1420–4	2002;62:1420–4	X
dti-1337	243	2	.	.	PROPN
dti-1337	244	1	26	26	NUM
dti-1337	244	2	.	.	PUNCT
dti-1337	245	1	schlager	schlager	PROPN
dti-1337	245	2	jj	jj	PROPN
dti-1337	245	3	.	.	PROPN
dti-1337	245	4	and	and	CCONJ
dti-1337	245	5	powis	powis	PROPN
dti-1337	245	6	g.	g.	PROPN
dti-1337	245	7	cytosolic	cytosolic	PROPN
dti-1337	245	8	nad(p)h:(quinoneacceptor)oxidoreductase	nad(p)h:(quinoneacceptor)oxidoreductase	PROPN
dti-1337	245	9	in	in	ADP
dti-1337	245	10	human	human	ADJ
dti-1337	245	11	normal	normal	ADJ
dti-1337	245	12	and	and	CCONJ
dti-1337	245	13	tumor	tumor	NOUN
dti-1337	245	14	tissue	tissue	NOUN
dti-1337	245	15	:	:	PUNCT
dti-1337	245	16	effects	effect	NOUN
dti-1337	245	17	of	of	ADP
dti-1337	245	18	cigarette	cigarette	NOUN
dti-1337	245	19	smoking	smoking	NOUN
dti-1337	245	20	and	and	CCONJ
dti-1337	245	21	alcohol	alcohol	NOUN
dti-1337	245	22	.	.	PUNCT
dti-1337	246	1	int	int	PROPN
dti-1337	246	2	j	j	PROPN
dti-1337	246	3	cancer	cancer	NOUN
dti-1337	246	4	.	.	PUNCT
dti-1337	247	1	1990;45:403–9	1990;45:403–9	NUM
dti-1337	247	2	.	.	PUNCT
dti-1337	248	1	27	27	NUM
dti-1337	248	2	.	.	PUNCT
dti-1337	248	3	smitskamp	smitskamp	NOUN
dti-1337	248	4	-	-	PUNCT
dti-1337	248	5	wilms	wilm	NOUN
dti-1337	248	6	eg	eg	NOUN
dti-1337	248	7	,	,	PUNCT
dti-1337	248	8	giaccone	giaccone	PROPN
dti-1337	248	9	g	g	PROPN
dti-1337	248	10	,	,	PUNCT
dti-1337	248	11	pinedo	pinedo	PROPN
dti-1337	248	12	hm	hm	INTJ
dti-1337	248	13	,	,	PUNCT
dti-1337	248	14	van	van	PROPN
dti-1337	248	15	der	der	PROPN
dti-1337	248	16	laan	laan	PROPN
dti-1337	248	17	bfam	bfam	PROPN
dti-1337	248	18	,	,	PUNCT
dti-1337	248	19	peters	peters	PROPN
dti-1337	248	20	gj	gj	PROPN
dti-1337	248	21	.	.	PUNCT
dti-1337	249	1	dt	dt	PROPN
dti-1337	249	2	-	-	PUNCT
dti-1337	249	3	diaphorase	diaphorase	NOUN
dti-1337	249	4	activity	activity	NOUN
dti-1337	249	5	in	in	ADP
dti-1337	249	6	normal	normal	ADJ
dti-1337	249	7	and	and	CCONJ
dti-1337	249	8	neoplastic	neoplastic	ADJ
dti-1337	249	9	human	human	ADJ
dti-1337	249	10	tissues	tissue	NOUN
dti-1337	249	11	;	;	PUNCT
dti-1337	249	12	an	an	DET
dti-1337	249	13	indicator	indicator	NOUN
dti-1337	249	14	for	for	ADP
dti-1337	249	15	sensitivity	sensitivity	NOUN
dti-1337	249	16	to	to	ADP
dti-1337	249	17	bioreductive	bioreductive	ADJ
dti-1337	249	18	agents	agent	NOUN
dti-1337	249	19	?	?	PUNCT
dti-1337	250	1	br	br	PROPN
dti-1337	250	2	j	j	PROPN
dti-1337	250	3	cancer	cancer	NOUN
dti-1337	250	4	.	.	PUNCT
dti-1337	251	1	1995;72:917–21	1995;72:917–21	X
dti-1337	251	2	.	.	PROPN
dti-1337	251	3	28	28	NUM
dti-1337	251	4	.	.	PUNCT
dti-1337	252	1	begleiter	begleiter	PROPN
dti-1337	252	2	a	a	PROPN
dti-1337	252	3	,	,	PUNCT
dti-1337	252	4	leith	leith	PROPN
dti-1337	252	5	mk	mk	PROPN
dti-1337	252	6	,	,	PUNCT
dti-1337	252	7	curphey	curphey	PROPN
dti-1337	252	8	tj	tj	PROPN
dti-1337	252	9	.	.	PROPN
dti-1337	252	10	,	,	PUNCT
dti-1337	252	11	doherty	doherty	PROPN
dti-1337	252	12	gp	gp	NOUN
dti-1337	252	13	.	.	PUNCT
dti-1337	253	1	induction	induction	NOUN
dti-1337	253	2	of	of	ADP
dti-1337	253	3	dt	dt	PROPN
dti-1337	253	4	-	-	PUNCT
dti-1337	253	5	diaphorase	diaphorase	NOUN
dti-1337	253	6	in	in	ADP
dti-1337	253	7	cancer	cancer	NOUN
dti-1337	253	8	chemoprevention	chemoprevention	NOUN
dti-1337	253	9	and	and	CCONJ
dti-1337	253	10	chemotherapy	chemotherapy	NOUN
dti-1337	253	11	.	.	PUNCT
dti-1337	254	1	oncol	oncol	ADJ
dti-1337	254	2	res	re	NOUN
dti-1337	254	3	.	.	PUNCT
dti-1337	255	1	1997;9:371–82	1997;9:371–82	NUM
dti-1337	255	2	.	.	PUNCT
dti-1337	255	3	29	29	NUM
dti-1337	255	4	.	.	PUNCT
dti-1337	256	1	twerdok	twerdok	PROPN
dti-1337	256	2	le	le	X
dti-1337	256	3	,	,	PUNCT
dti-1337	256	4	rembish	rembish	PROPN
dti-1337	256	5	sj	sj	PROPN
dti-1337	256	6	,	,	PUNCT
dti-1337	256	7	trush	trush	PROPN
dti-1337	256	8	ma	ma	PROPN
dti-1337	256	9	.	.	PROPN
dti-1337	256	10	induction	induction	NOUN
dti-1337	256	11	of	of	ADP
dti-1337	256	12	quinone	quinone	NOUN
dti-1337	256	13	reductase	reductase	NOUN
dti-1337	256	14	and	and	CCONJ
dti-1337	256	15	glutathione	glutathione	NOUN
dti-1337	256	16	in	in	ADP
dti-1337	256	17	bone	bone	NOUN
dti-1337	256	18	marrow	marrow	NOUN
dti-1337	256	19	cells	cell	NOUN
dti-1337	256	20	by	by	ADP
dti-1337	256	21	1,2	1,2	NUM
dti-1337	256	22	-	-	PUNCT
dti-1337	256	23	dithiole-3	dithiole-3	VERB
dti-1337	256	24	-	-	ADJ
dti-1337	256	25	thione	thione	NOUN
dti-1337	256	26	:	:	PUNCT
dti-1337	256	27	effect	effect	NOUN
dti-1337	256	28	on	on	ADP
dti-1337	256	29	hydroquinone	hydroquinone	NOUN
dti-1337	256	30	-	-	PUNCT
dti-1337	256	31	induced	induce	VERB
dti-1337	256	32	cytotoxicity	cytotoxicity	NOUN
dti-1337	256	33	.	.	PUNCT
dti-1337	257	1	toxicol	toxicol	PROPN
dti-1337	257	2	applied	apply	VERB
dti-1337	257	3	pharmacol	pharmacol	NOUN
dti-1337	257	4	.	.	PUNCT
dti-1337	258	1	1992;112:273–81	1992;112:273–81	NUM
dti-1337	258	2	.	.	NOUN
dti-1337	259	1	30	30	NUM
dti-1337	259	2	.	.	PUNCT
dti-1337	260	1	begleiter	begleiter	PROPN
dti-1337	260	2	a	a	PROPN
dti-1337	260	3	,	,	PUNCT
dti-1337	260	4	robotham	robotham	PROPN
dti-1337	260	5	e	e	NOUN
dti-1337	260	6	,	,	PUNCT
dti-1337	260	7	lacey	lacey	VERB
dti-1337	260	8	g	g	PROPN
dti-1337	260	9	,	,	PUNCT
dti-1337	260	10	leith	leith	PROPN
dti-1337	260	11	mk	mk	PROPN
dti-1337	260	12	.	.	PROPN
dti-1337	261	1	increased	increase	VERB
dti-1337	261	2	sensitivity	sensitivity	NOUN
dti-1337	261	3	of	of	ADP
dti-1337	261	4	quinone	quinone	NOUN
dti-1337	261	5	resistant	resistant	ADJ
dti-1337	261	6	cells	cell	NOUN
dti-1337	261	7	to	to	ADP
dti-1337	261	8	mitomycin	mitomycin	PROPN
dti-1337	261	9	c.	c.	PROPN
dti-1337	261	10	cancer	cancer	PROPN
dti-1337	261	11	lett	lett	PROPN
dti-1337	261	12	.	.	PUNCT
dti-1337	262	1	1989;45:173–6	1989;45:173–6	NUM
dti-1337	262	2	.	.	PUNCT
dti-1337	263	1	31	31	NUM
dti-1337	263	2	.	.	PUNCT
dti-1337	264	1	siegel	siegel	PROPN
dti-1337	264	2	d	d	PROPN
dti-1337	264	3	,	,	PUNCT
dti-1337	264	4	gibson	gibson	PROPN
dti-1337	264	5	nw	nw	PROPN
dti-1337	264	6	,	,	PUNCT
dti-1337	264	7	preusch	preusch	PROPN
dti-1337	264	8	pc	pc	PROPN
dti-1337	264	9	,	,	PUNCT
dti-1337	264	10	ross	ross	PROPN
dti-1337	264	11	d.	d.	PROPN
dti-1337	264	12	metabolism	metabolism	NOUN
dti-1337	264	13	of	of	ADP
dti-1337	264	14	mitomycin	mitomycin	PROPN
dti-1337	264	15	c	c	PROPN
dti-1337	264	16	by	by	ADP
dti-1337	264	17	dt	dt	PROPN
dti-1337	264	18	-	-	PUNCT
dti-1337	264	19	diaphorase	diaphorase	NOUN
dti-1337	264	20	:	:	PUNCT
dti-1337	264	21	role	role	NOUN
dti-1337	264	22	in	in	ADP
dti-1337	264	23	mitomycin	mitomycin	PROPN
dti-1337	264	24	c	c	NOUN
dti-1337	264	25	-	-	PUNCT
dti-1337	264	26	induced	induce	VERB
dti-1337	264	27	dna	dna	PROPN
dti-1337	264	28	damage	damage	NOUN
dti-1337	264	29	and	and	CCONJ
dti-1337	264	30	cytotoxicity	cytotoxicity	NOUN
dti-1337	264	31	in	in	ADP
dti-1337	264	32	human	human	ADJ
dti-1337	264	33	colon	colon	NOUN
dti-1337	264	34	carcinoma	carcinoma	NOUN
dti-1337	264	35	cells	cell	NOUN
dti-1337	264	36	.	.	PUNCT
dti-1337	265	1	cancer	cancer	NOUN
dti-1337	265	2	res	re	NOUN
dti-1337	265	3	.	.	PUNCT
dti-1337	265	4	1990	1990	NUM
dti-1337	265	5	;	;	PUNCT
dti-1337	265	6	50:7483–9	50:7483–9	NUM
dti-1337	265	7	.	.	PUNCT
dti-1337	266	1	32	32	NUM
dti-1337	266	2	.	.	PUNCT
dti-1337	267	1	pan	pan	PROPN
dti-1337	267	2	s	s	PROPN
dti-1337	267	3	,	,	PUNCT
dti-1337	267	4	akman	akman	PROPN
dti-1337	267	5	sa	sa	PROPN
dti-1337	267	6	,	,	PUNCT
dti-1337	267	7	forrest	forrest	PROPN
dti-1337	267	8	gl	gl	PROPN
dti-1337	267	9	,	,	PUNCT
dti-1337	267	10	hipsher	hipsher	PROPN
dti-1337	267	11	c	c	PROPN
dti-1337	267	12	,	,	PUNCT
dti-1337	267	13	johnson	johnson	PROPN
dti-1337	267	14	r.	r.	PROPN
dti-1337	267	15	the	the	DET
dti-1337	267	16	role	role	NOUN
dti-1337	267	17	of	of	ADP
dti-1337	267	18	nad(p)h	nad(p)h	NOUN
dti-1337	267	19	:	:	PUNCT
dti-1337	267	20	quinone	quinone	NOUN
dti-1337	267	21	oxidoreductase	oxidoreductase	NOUN
dti-1337	267	22	in	in	ADP
dti-1337	267	23	mitomycin	mitomycin	PROPN
dti-1337	267	24	cand	cand	PROPN
dti-1337	267	25	porfi	porfi	VERB
dti-1337	267	26	romycinresistant	romycinresistant	PROPN
dti-1337	267	27	hct	hct	PROPN
dti-1337	267	28	116	116	NUM
dti-1337	267	29	human	human	ADJ
dti-1337	267	30	colon	colon	NOUN
dti-1337	267	31	-	-	PUNCT
dti-1337	267	32	cancer	cancer	NOUN
dti-1337	267	33	cells	cell	NOUN
dti-1337	267	34	.	.	PUNCT
dti-1337	268	1	cancer	cancer	NOUN
dti-1337	268	2	chemother	chemother	PROPN
dti-1337	268	3	pharmacol	pharmacol	PROPN
dti-1337	268	4	.	.	PUNCT
dti-1337	269	1	1992;31:23–31	1992;31:23–31	NUM
dti-1337	269	2	.	.	PROPN
dti-1337	270	1	33	33	NUM
dti-1337	270	2	.	.	PUNCT
dti-1337	271	1	beall	beall	PROPN
dti-1337	271	2	hd	hd	PROPN
dti-1337	271	3	,	,	PUNCT
dti-1337	271	4	murphy	murphy	PROPN
dti-1337	271	5	am	am	PROPN
dti-1337	271	6	,	,	PUNCT
dti-1337	271	7	siegel	siegel	PROPN
dti-1337	271	8	d	d	PROPN
dti-1337	271	9	,	,	PUNCT
dti-1337	271	10	hargreaves	hargreaves	PROPN
dti-1337	271	11	rhj	rhj	PROPN
dti-1337	271	12	,	,	PUNCT
dti-1337	271	13	butler	butler	PROPN
dti-1337	271	14	j	j	PROPN
dti-1337	271	15	,	,	PUNCT
dti-1337	271	16	ross	ross	PROPN
dti-1337	271	17	d.	d.	PROPN
dti-1337	271	18	nicotinamide	nicotinamide	PROPN
dti-1337	271	19	adenine	adenine	ADJ
dti-1337	271	20	dinucleotide	dinucleotide	NOUN
dti-1337	271	21	(	(	PUNCT
dti-1337	271	22	phosphate):quinone	phosphate):quinone	NOUN
dti-1337	271	23	oxidoreductase	oxidoreductase	NOUN
dti-1337	271	24	(	(	PUNCT
dti-1337	271	25	dt	dt	NOUN
dti-1337	271	26	-	-	PUNCT
dti-1337	271	27	diaphorase	diaphorase	NOUN
dti-1337	271	28	)	)	PUNCT
dti-1337	271	29	as	as	ADP
dti-1337	271	30	a	a	DET
dti-1337	271	31	target	target	NOUN
dti-1337	271	32	for	for	ADP
dti-1337	271	33	bioreductive	bioreductive	ADJ
dti-1337	271	34	antitumour	antitumour	NOUN
dti-1337	271	35	quinones	quinone	NOUN
dti-1337	271	36	:	:	PUNCT
dti-1337	271	37	quinone	quinone	NOUN
dti-1337	271	38	cytotoxicity	cytotoxicity	NOUN
dti-1337	271	39	and	and	CCONJ
dti-1337	271	40	selectivity	selectivity	NOUN
dti-1337	271	41	in	in	ADP
dti-1337	271	42	human	human	ADJ
dti-1337	271	43	lung	lung	NOUN
dti-1337	271	44	and	and	CCONJ
dti-1337	271	45	breast	breast	NOUN
dti-1337	271	46	cancer	cancer	NOUN
dti-1337	271	47	cell	cell	NOUN
dti-1337	271	48	lines	line	NOUN
dti-1337	271	49	.	.	PUNCT
dti-1337	272	1	mol	mol	ADP
dti-1337	272	2	pharmacol	pharmacol	PROPN
dti-1337	272	3	.	.	PUNCT
dti-1337	273	1	1995;48:499–504	1995;48:499–504	NOUN
dti-1337	273	2	.	.	PUNCT
dti-1337	274	1	34	34	NUM
dti-1337	274	2	.	.	PUNCT
dti-1337	275	1	plumb	plumb	PROPN
dti-1337	275	2	ja	ja	PROPN
dti-1337	275	3	,	,	PUNCT
dti-1337	275	4	gerritsen	gerritsen	PROPN
dti-1337	275	5	m	m	PROPN
dti-1337	275	6	,	,	PUNCT
dti-1337	275	7	milroy	milroy	PROPN
dti-1337	276	1	r	r	PROPN
dti-1337	276	2	,	,	PUNCT
dti-1337	276	3	thomson	thomson	NOUN
dti-1337	276	4	p	p	NOUN
dti-1337	276	5	,	,	PUNCT
dti-1337	276	6	workman	workman	NOUN
dti-1337	276	7	p.	p.	NOUN
dti-1337	276	8	relative	relative	ADJ
dti-1337	276	9	importance	importance	NOUN
dti-1337	276	10	of	of	ADP
dti-1337	276	11	dt	dt	NOUN
dti-1337	276	12	-	-	PUNCT
dti-1337	276	13	diaphorase	diaphorase	NOUN
dti-1337	276	14	and	and	CCONJ
dti-1337	276	15	hypoxia	hypoxia	NOUN
dti-1337	276	16	in	in	ADP
dti-1337	276	17	the	the	DET
dti-1337	276	18	bioactivation	bioactivation	NOUN
dti-1337	276	19	of	of	ADP
dti-1337	276	20	eo9	eo9	NUM
dti-1337	276	21	by	by	ADP
dti-1337	276	22	human	human	ADJ
dti-1337	276	23	lung	lung	PROPN
dti-1337	276	24	tumor	tumor	NOUN
dti-1337	276	25	cell	cell	NOUN
dti-1337	276	26	lines	line	NOUN
dti-1337	276	27	.	.	PUNCT
dti-1337	277	1	int	int	NOUN
dti-1337	277	2	j	j	PROPN
dti-1337	277	3	radiat	radiat	PROPN
dti-1337	277	4	oncol	oncol	ADJ
dti-1337	277	5	biol	biol	PROPN
dti-1337	277	6	phys	phy	NOUN
dti-1337	277	7	.	.	PUNCT
dti-1337	278	1	1994;29:295–9	1994;29:295–9	NUM
dti-1337	278	2	.	.	PUNCT
dti-1337	279	1	35	35	NUM
dti-1337	279	2	.	.	PUNCT
dti-1337	280	1	winski	winski	PROPN
dti-1337	280	2	sl	sl	PROPN
dti-1337	280	3	,	,	PUNCT
dti-1337	280	4	swann	swann	PROPN
dti-1337	280	5	e	e	PROPN
dti-1337	280	6	,	,	PUNCT
dti-1337	280	7	hargreaves	hargreaves	PROPN
dti-1337	280	8	rhj	rhj	PROPN
dti-1337	280	9	,	,	PUNCT
dti-1337	280	10	et	et	PROPN
dti-1337	280	11	al	al	PROPN
dti-1337	280	12	.	.	PROPN
dti-1337	280	13	relationship	relationship	NOUN
dti-1337	280	14	between	between	ADP
dti-1337	280	15	nad(p)h	nad(p)h	NOUN
dti-1337	280	16	:	:	PUNCT
dti-1337	280	17	quinone	quinone	NOUN
dti-1337	280	18	oxidoreductase	oxidoreductase	NOUN
dti-1337	280	19	1	1	NUM
dti-1337	280	20	(	(	PUNCT
dti-1337	280	21	nqo1	nqo1	PROPN
dti-1337	280	22	)	)	PUNCT
dti-1337	280	23	levels	level	NOUN
dti-1337	280	24	in	in	ADP
dti-1337	280	25	a	a	DET
dti-1337	280	26	series	series	NOUN
dti-1337	280	27	of	of	ADP
dti-1337	280	28	stably	stably	ADV
dti-1337	280	29	transfected	transfecte	VERB
dti-1337	280	30	cell	cell	NOUN
dti-1337	280	31	lines	line	NOUN
dti-1337	280	32	and	and	CCONJ
dti-1337	280	33	susceptibility	susceptibility	NOUN
dti-1337	280	34	to	to	ADP
dti-1337	280	35	antitumor	antitumor	PROPN
dti-1337	280	36	quinones	quinone	NOUN
dti-1337	280	37	.	.	PUNCT
dti-1337	281	1	biochem	biochem	PROPN
dti-1337	281	2	pharmacol	pharmacol	PROPN
dti-1337	281	3	..	..	PROPN
dti-1337	282	1	2001;61:1509–16	2001;61:1509–16	NUM
dti-1337	282	2	.	.	NOUN
dti-1337	282	3	36	36	NUM
dti-1337	282	4	.	.	X
dti-1337	282	5	malkinson	malkinson	PROPN
dti-1337	282	6	am	be	AUX
dti-1337	282	7	,	,	PUNCT
dti-1337	282	8	siegel	siegel	PROPN
dti-1337	282	9	d	d	PROPN
dti-1337	282	10	,	,	PUNCT
dti-1337	282	11	forrest	forrest	PROPN
dti-1337	282	12	gl	gl	PROPN
dti-1337	282	13	,	,	PUNCT
dti-1337	282	14	et	et	PROPN
dti-1337	282	15	al	al	PROPN
dti-1337	282	16	.	.	PROPN
dti-1337	282	17	elevated	elevate	VERB
dti-1337	282	18	dt	dt	ADJ
dti-1337	282	19	-	-	PUNCT
dti-1337	282	20	diaphorase	diaphorase	NOUN
dti-1337	282	21	activity	activity	NOUN
dti-1337	282	22	and	and	CCONJ
dti-1337	282	23	messenger	messenger	NOUN
dti-1337	282	24	rna	rna	NOUN
dti-1337	282	25	content	content	NOUN
dti-1337	282	26	in	in	ADP
dti-1337	282	27	human	human	ADJ
dti-1337	282	28	non	non	ADJ
dti-1337	282	29	-	-	ADJ
dti-1337	282	30	small	small	ADJ
dti-1337	282	31	lung	lung	NOUN
dti-1337	282	32	carcinoma	carcinoma	NOUN
dti-1337	282	33	:	:	PUNCT
dti-1337	282	34	relationship	relationship	NOUN
dti-1337	282	35	to	to	ADP
dti-1337	282	36	the	the	DET
dti-1337	282	37	response	response	NOUN
dti-1337	282	38	of	of	ADP
dti-1337	282	39	lung	lung	NOUN
dti-1337	282	40	xenografts	xenograft	NOUN
dti-1337	282	41	to	to	ADP
dti-1337	282	42	mitomycin	mitomycin	PROPN
dti-1337	282	43	c.	c.	PROPN
dti-1337	282	44	cancer	cancer	NOUN
dti-1337	282	45	res	re	NOUN
dti-1337	282	46	.	.	PUNCT
dti-1337	283	1	1992;52:4752–7	1992;52:4752–7	NOUN
dti-1337	283	2	.	.	PUNCT
dti-1337	284	1	37	37	NUM
dti-1337	284	2	.	.	PUNCT
dti-1337	285	1	marshall	marshall	PROPN
dti-1337	285	2	rs	rs	PROPN
dti-1337	285	3	,	,	PUNCT
dti-1337	285	4	patterson	patterson	PROPN
dti-1337	285	5	mc	mc	PROPN
dti-1337	285	6	,	,	PUNCT
dti-1337	285	7	rauth	rauth	PROPN
dti-1337	285	8	am	be	AUX
dti-1337	285	9	.	.	PUNCT
dti-1337	286	1	dt	dt	ADJ
dti-1337	286	2	-	-	PUNCT
dti-1337	286	3	diaphorase	diaphorase	NOUN
dti-1337	286	4	activity	activity	NOUN
dti-1337	286	5	and	and	CCONJ
dti-1337	286	6	mitomycin	mitomycin	NOUN
dti-1337	286	7	c	c	PROPN
dti-1337	286	8	sensitivity	sensitivity	NOUN
dti-1337	286	9	in	in	ADP
dti-1337	286	10	non	non	ADJ
dti-1337	286	11	-	-	ADJ
dti-1337	286	12	transformed	transform	VERB
dti-1337	286	13	cell	cell	NOUN
dti-1337	286	14	strains	strain	NOUN
dti-1337	286	15	derived	derive	VERB
dti-1337	286	16	from	from	ADP
dti-1337	286	17	members	member	NOUN
dti-1337	286	18	of	of	ADP
dti-1337	286	19	a	a	DET
dti-1337	286	20	cancer	cancer	NOUN
dti-1337	286	21	-	-	PUNCT
dti-1337	286	22	prone	prone	ADJ
dti-1337	286	23	family	family	NOUN
dti-1337	286	24	.	.	PUNCT
dti-1337	287	1	carcinogenesis	carcinogenesis	NOUN
dti-1337	287	2	.	.	PUNCT
dti-1337	288	1	1991;12:1175–80	1991;12:1175–80	NUM
dti-1337	288	2	.	.	PUNCT
dti-1337	289	1	38	38	NUM
dti-1337	289	2	.	.	PUNCT
dti-1337	289	3	dusre	dusre	NOUN
dti-1337	289	4	l	l	PROPN
dti-1337	289	5	,	,	PUNCT
dti-1337	289	6	covey	covey	PROPN
dti-1337	289	7	jm	jm	PROPN
dti-1337	289	8	,	,	PUNCT
dti-1337	289	9	collins	collins	PROPN
dti-1337	289	10	c	c	PROPN
dti-1337	289	11	,	,	PUNCT
dti-1337	289	12	sinha	sinha	NOUN
dti-1337	289	13	bk	bk	PROPN
dti-1337	289	14	.	.	PUNCT
dti-1337	289	15	dna	dna	PROPN
dti-1337	289	16	damage	damage	NOUN
dti-1337	289	17	,	,	PUNCT
dti-1337	289	18	cytotoxicity	cytotoxicity	NOUN
dti-1337	289	19	and	and	CCONJ
dti-1337	289	20	free	free	ADJ
dti-1337	289	21	radical	radical	ADJ
dti-1337	289	22	formation	formation	NOUN
dti-1337	289	23	by	by	ADP
dti-1337	289	24	mitomycin	mitomycin	PROPN
dti-1337	289	25	c	c	PROPN
dti-1337	289	26	in	in	ADP
dti-1337	289	27	human	human	ADJ
dti-1337	289	28	cells	cell	NOUN
dti-1337	289	29	.	.	PUNCT
dti-1337	290	1	chem	chem	PROPN
dti-1337	290	2	biol	biol	PROPN
dti-1337	290	3	interac	interac	PROPN
dti-1337	290	4	.	.	PUNCT
dti-1337	291	1	1989;71:63–78	1989;71:63–78	NUM
dti-1337	291	2	.	.	X
dti-1337	292	1	39	39	NUM
dti-1337	292	2	.	.	PUNCT
dti-1337	293	1	begleiter	begleiter	NOUN
dti-1337	293	2	a	a	PROPN
dti-1337	293	3	and	and	CCONJ
dti-1337	293	4	leith	leith	PROPN
dti-1337	293	5	mk	mk	PROPN
dti-1337	293	6	.	.	PUNCT
dti-1337	294	1	activity	activity	NOUN
dti-1337	294	2	of	of	ADP
dti-1337	294	3	quinone	quinone	NOUN
dti-1337	294	4	alkylating	alkylating	NOUN
dti-1337	294	5	agents	agent	NOUN
dti-1337	294	6	in	in	ADP
dti-1337	294	7	quinone	quinone	NOUN
dti-1337	294	8	-	-	PUNCT
dti-1337	294	9	resistant	resistant	ADJ
dti-1337	294	10	cells	cell	NOUN
dti-1337	294	11	.	.	PUNCT
dti-1337	295	1	cancer	cancer	NOUN
dti-1337	295	2	res	re	NOUN
dti-1337	295	3	.	.	PUNCT
dti-1337	296	1	1990;50:2872–6	1990;50:2872–6	X
dti-1337	297	1	.	.	PROPN
dti-1337	297	2	40	40	NUM
dti-1337	297	3	.	.	PUNCT
dti-1337	298	1	begleiter	begleiter	PROPN
dti-1337	298	2	a	a	PROPN
dti-1337	298	3	,	,	PUNCT
dti-1337	298	4	lee	lee	PROPN
dti-1337	298	5	k	k	PROPN
dti-1337	298	6	,	,	PUNCT
dti-1337	298	7	israels	israels	PROPN
dti-1337	298	8	lg	lg	PROPN
dti-1337	298	9	,	,	PUNCT
dti-1337	298	10	mowat	mowat	PROPN
dti-1337	298	11	mra	mra	PROPN
dti-1337	298	12	,	,	PUNCT
dti-1337	298	13	johnston	johnston	PROPN
dti-1337	298	14	jb	jb	PROPN
dti-1337	298	15	.	.	PUNCT
dti-1337	299	1	chlorambucil	chlorambucil	PROPN
dti-1337	299	2	induced	induce	VERB
dti-1337	299	3	apoptosis	apoptosis	NOUN
dti-1337	299	4	in	in	ADP
dti-1337	299	5	chronic	chronic	ADJ
dti-1337	299	6	lymphocytic	lymphocytic	ADJ
dti-1337	299	7	leukemia	leukemia	NOUN
dti-1337	299	8	(	(	PUNCT
dti-1337	299	9	cll	cll	PROPN
dti-1337	299	10	)	)	PUNCT
dti-1337	299	11	and	and	CCONJ
dti-1337	299	12	its	its	PRON
dti-1337	299	13	relationship	relationship	NOUN
dti-1337	299	14	to	to	ADP
dti-1337	299	15	clinical	clinical	ADJ
dti-1337	299	16	effi	effi	PROPN
dti-1337	299	17	cacy	cacy	NOUN
dti-1337	299	18	.	.	PUNCT
dti-1337	300	1	leukemia	leukemia	NOUN
dti-1337	300	2	.	.	PUNCT
dti-1337	301	1	1994;8(suppl	1994;8(suppl	X
dti-1337	301	2	1):s103–6	1):s103–6	NUM
dti-1337	301	3	.	.	PUNCT
dti-1337	302	1	41	41	NUM
dti-1337	302	2	.	.	PUNCT
dti-1337	303	1	fourie	fourie	PROPN
dti-1337	303	2	j	j	PROPN
dti-1337	303	3	,	,	PUNCT
dti-1337	303	4	oleschuk	oleschuk	ADJ
dti-1337	303	5	c	c	NOUN
dti-1337	303	6	,	,	PUNCT
dti-1337	303	7	guziec	guziec	PROPN
dti-1337	303	8	f	f	PROPN
dti-1337	303	9	jr	jr	PROPN
dti-1337	303	10	,	,	PUNCT
dti-1337	303	11	et	et	PROPN
dti-1337	303	12	al	al	PROPN
dti-1337	303	13	.	.	PUNCT
dti-1337	304	1	the	the	DET
dti-1337	304	2	effect	effect	NOUN
dti-1337	304	3	of	of	ADP
dti-1337	304	4	functional	functional	ADJ
dti-1337	304	5	groups	group	NOUN
dti-1337	304	6	on	on	ADP
dti-1337	304	7	reduction	reduction	NOUN
dti-1337	304	8	and	and	CCONJ
dti-1337	304	9	activation	activation	NOUN
dti-1337	304	10	of	of	ADP
dti-1337	304	11	quinone	quinone	NOUN
dti-1337	304	12	bioreductive	bioreductive	ADJ
dti-1337	304	13	agents	agent	NOUN
dti-1337	304	14	by	by	ADP
dti-1337	304	15	dt	dt	PROPN
dti-1337	304	16	-	-	PUNCT
dti-1337	304	17	diaphorase	diaphorase	NOUN
dti-1337	304	18	.	.	PUNCT
dti-1337	305	1	cancer	cancer	NOUN
dti-1337	305	2	chemother	chemother	PROPN
dti-1337	305	3	pharmacol	pharmacol	PROPN
dti-1337	305	4	.	.	PUNCT
dti-1337	306	1	2002;49:101–10	2002;49:101–10	X
dti-1337	306	2	.	.	PUNCT
dti-1337	307	1	42	42	NUM
dti-1337	307	2	.	.	PUNCT
dti-1337	308	1	fourie	fourie	PROPN
dti-1337	308	2	j	j	PROPN
dti-1337	308	3	,	,	PUNCT
dti-1337	308	4	guziec	guziec	PROPN
dti-1337	308	5	f	f	PROPN
dti-1337	308	6	jr	jr	PROPN
dti-1337	308	7	,	,	PUNCT
dti-1337	308	8	guziec	guziec	PROPN
dti-1337	308	9	l	l	PROPN
dti-1337	308	10	,	,	PUNCT
dti-1337	308	11	fiterman	fiterman	NOUN
dti-1337	308	12	dj	dj	PROPN
dti-1337	308	13	,	,	PUNCT
dti-1337	308	14	monterrosa	monterrosa	PROPN
dti-1337	308	15	c	c	NOUN
dti-1337	308	16	,	,	PUNCT
dti-1337	308	17	begleiter	begleiter	NOUN
dti-1337	308	18	a.	a.	NOUN
dti-1337	308	19	structure	structure	NOUN
dti-1337	308	20	-	-	PUNCT
dti-1337	308	21	activity	activity	NOUN
dti-1337	308	22	study	study	NOUN
dti-1337	308	23	of	of	ADP
dti-1337	308	24	benzoquinone	benzoquinone	NOUN
dti-1337	308	25	bioreductive	bioreductive	ADJ
dti-1337	308	26	alkylating	alkylate	VERB
dti-1337	308	27	agents	agent	NOUN
dti-1337	308	28	:	:	PUNCT
dti-1337	308	29	effects	effect	NOUN
dti-1337	308	30	on	on	ADP
dti-1337	308	31	dt	dt	PROPN
dti-1337	308	32	-	-	PUNCT
dti-1337	308	33	diaphorase	diaphorase	NOUN
dti-1337	308	34	mediated	mediate	VERB
dti-1337	308	35	dna	dna	PROPN
dti-1337	308	36	cross	cross	NOUN
dti-1337	308	37	-	-	NOUN
dti-1337	308	38	link	link	ADJ
dti-1337	308	39	and	and	CCONJ
dti-1337	308	40	strand	strand	NOUN
dti-1337	308	41	break	break	NOUN
dti-1337	308	42	formation	formation	NOUN
dti-1337	308	43	and	and	CCONJ
dti-1337	308	44	relation	relation	NOUN
dti-1337	308	45	to	to	ADP
dti-1337	308	46	mechanisms	mechanism	NOUN
dti-1337	308	47	of	of	ADP
dti-1337	308	48	cytotoxicity	cytotoxicity	NOUN
dti-1337	308	49	.	.	PUNCT
dti-1337	309	1	cancer	cancer	NOUN
dti-1337	309	2	chemother	chemother	PROPN
dti-1337	309	3	pharmacol	pharmacol	PROPN
dti-1337	309	4	.	.	PUNCT
dti-1337	310	1	2004;53:191–203	2004;53:191–203	X
dti-1337	310	2	.	.	PUNCT
dti-1337	311	1	43	43	NUM
dti-1337	311	2	.	.	PUNCT
dti-1337	312	1	doherty	doherty	PROPN
dti-1337	312	2	gp	gp	PROPN
dti-1337	312	3	,	,	PUNCT
dti-1337	312	4	leith	leith	PROPN
dti-1337	312	5	mk	mk	PROPN
dti-1337	312	6	,	,	PUNCT
dti-1337	312	7	wang	wang	PROPN
dti-1337	312	8	x	x	PROPN
dti-1337	312	9	,	,	PUNCT
dti-1337	312	10	curphey	curphey	PROPN
dti-1337	312	11	tj	tj	PROPN
dti-1337	312	12	,	,	PUNCT
dti-1337	312	13	begleiter	begleiter	NOUN
dti-1337	312	14	a.	a.	NOUN
dti-1337	312	15	induction	induction	NOUN
dti-1337	312	16	of	of	ADP
dti-1337	312	17	dt	dt	PROPN
dti-1337	312	18	-	-	PUNCT
dti-1337	312	19	diaphorase	diaphorase	NOUN
dti-1337	312	20	by	by	ADP
dti-1337	312	21	1,2	1,2	NUM
dti-1337	312	22	-	-	PUNCT
dti-1337	312	23	dithiole-3	dithiole-3	NOUN
dti-1337	312	24	-	-	PUNCT
dti-1337	312	25	thiones	thione	NOUN
dti-1337	312	26	in	in	ADP
dti-1337	312	27	human	human	ADJ
dti-1337	312	28	tumour	tumour	NOUN
dti-1337	312	29	and	and	CCONJ
dti-1337	312	30	normal	normal	ADJ
dti-1337	312	31	cells	cell	NOUN
dti-1337	312	32	and	and	CCONJ
dti-1337	312	33	effect	effect	NOUN
dti-1337	312	34	on	on	ADP
dti-1337	312	35	antitumour	antitumour	NOUN
dti-1337	312	36	activity	activity	NOUN
dti-1337	312	37	of	of	ADP
dti-1337	312	38	bioreductive	bioreductive	ADJ
dti-1337	312	39	agents	agent	NOUN
dti-1337	312	40	.	.	PUNCT
dti-1337	313	1	br	br	PROPN
dti-1337	313	2	j	j	PROPN
dti-1337	313	3	cancer	cancer	NOUN
dti-1337	313	4	.	.	PUNCT
dti-1337	314	1	1998;77:1241–52	1998;77:1241–52	NUM
dti-1337	314	2	.	.	PUNCT
dti-1337	315	1	44	44	NUM
dti-1337	315	2	.	.	PUNCT
dti-1337	316	1	johnston	johnston	PROPN
dti-1337	316	2	jb	jb	PROPN
dti-1337	316	3	,	,	PUNCT
dti-1337	316	4	verburg	verburg	PROPN
dti-1337	316	5	l	l	NOUN
dti-1337	316	6	,	,	PUNCT
dti-1337	316	7	shore	shore	PROPN
dti-1337	316	8	t	t	PROPN
dti-1337	316	9	,	,	PUNCT
dti-1337	316	10	williams	williams	PROPN
dti-1337	316	11	m	m	PROPN
dti-1337	316	12	,	,	PUNCT
dti-1337	316	13	israels	israels	PROPN
dti-1337	316	14	lg	lg	NOUN
dti-1337	316	15	,	,	PUNCT
dti-1337	316	16	begleiter	begleiter	NOUN
dti-1337	316	17	a.	a.	NOUN
dti-1337	316	18	combination	combination	NOUN
dti-1337	316	19	therapy	therapy	NOUN
dti-1337	316	20	with	with	ADP
dti-1337	316	21	nucleoside	nucleoside	NOUN
dti-1337	316	22	analogs	analog	NOUN
dti-1337	316	23	and	and	CCONJ
dti-1337	316	24	alkylating	alkylate	VERB
dti-1337	316	25	agents	agent	NOUN
dti-1337	316	26	.	.	PUNCT
dti-1337	317	1	leukemia	leukemia	NOUN
dti-1337	317	2	.	.	PUNCT
dti-1337	318	1	1994;8(suppl	1994;8(suppl	X
dti-1337	318	2	1):s140–3	1):s140–3	NUM
dti-1337	318	3	.	.	PUNCT
dti-1337	319	1	45	45	NUM
dti-1337	319	2	.	.	PUNCT
dti-1337	319	3	kirkpatrick	kirkpatrick	PROPN
dti-1337	319	4	dl	dl	PROPN
dti-1337	319	5	,	,	PUNCT
dti-1337	319	6	duke	duke	PROPN
dti-1337	319	7	m	m	PROPN
dti-1337	319	8	,	,	PUNCT
dti-1337	319	9	goh	goh	PROPN
dti-1337	319	10	ts	ts	PROPN
dti-1337	319	11	.	.	PROPN
dti-1337	319	12	chemosensitivity	chemosensitivity	PROPN
dti-1337	319	13	testing	testing	NOUN
dti-1337	319	14	of	of	ADP
dti-1337	319	15	fresh	fresh	ADJ
dti-1337	319	16	human	human	ADJ
dti-1337	319	17	leukemia	leukemia	NOUN
dti-1337	319	18	cells	cell	NOUN
dti-1337	319	19	using	use	VERB
dti-1337	319	20	both	both	CCONJ
dti-1337	319	21	a	a	DET
dti-1337	319	22	dye	dye	NOUN
dti-1337	319	23	exclusion	exclusion	NOUN
dti-1337	319	24	assay	assay	NOUN
dti-1337	319	25	and	and	CCONJ
dti-1337	319	26	a	a	DET
dti-1337	319	27	tetrazolium	tetrazolium	NOUN
dti-1337	319	28	dye	dye	NOUN
dti-1337	319	29	(	(	PUNCT
dti-1337	319	30	mtt	mtt	NOUN
dti-1337	319	31	)	)	PUNCT
dti-1337	319	32	assay	assay	VERB
dti-1337	319	33	.	.	PUNCT
dti-1337	320	1	leuk	leuk	PROPN
dti-1337	320	2	res	res	PROPN
dti-1337	320	3	.	.	PUNCT
dti-1337	321	1	1990;14:459–66	1990;14:459–66	X
dti-1337	321	2	.	.	PUNCT
dti-1337	322	1	<	<	X
dti-1337	322	2	<	<	X
dti-1337	322	3	/ascii85encodepages	/ascii85encodepage	NOUN
dti-1337	322	4	false	false	ADJ
dti-1337	322	5	/allowtransparency	/allowtransparency	NOUN
dti-1337	322	6	false	false	ADJ
dti-1337	322	7	/autopositionepsfiles	/autopositionepsfile	NOUN
dti-1337	322	8	true	true	ADJ
dti-1337	322	9	/autorotatepages	/autorotatepage	NOUN
dti-1337	322	10	/none	/none	PUNCT
dti-1337	322	11	/binding	/binding	PUNCT
dti-1337	322	12	/left	/left	ADJ
dti-1337	323	1	/calgrayprofile	/calgrayprofile	VERB
dti-1337	323	2	(	(	PUNCT
dti-1337	323	3	dot	dot	NOUN
dti-1337	323	4	gain	gain	NOUN
dti-1337	323	5	20	20	NUM
dti-1337	323	6	%	%	NOUN
dti-1337	323	7	)	)	PUNCT
dti-1337	323	8	/calrgbprofile	/calrgbprofile	PUNCT
dti-1337	324	1	(	(	PUNCT
dti-1337	324	2	srgb	srgb	PROPN
dti-1337	324	3	iec61966	iec61966	NOUN
dti-1337	324	4	-	-	PUNCT
dti-1337	324	5	2.1	2.1	NUM
dti-1337	324	6	)	)	PUNCT
dti-1337	324	7	/calcmykprofile	/calcmykprofile	PUNCT
dti-1337	325	1	(	(	PUNCT
dti-1337	325	2	u.s	u.s	PROPN
dti-1337	325	3	.	.	PROPN
dti-1337	325	4	web	web	NOUN
dti-1337	325	5	coated	coat	VERB
dti-1337	325	6	\050swop\051	\050swop\051	ADJ
dti-1337	325	7	v2	v2	NOUN
dti-1337	325	8	)	)	PUNCT
dti-1337	325	9	/srgbprofile	/srgbprofile	PUNCT
dti-1337	325	10	(	(	PUNCT
dti-1337	325	11	srgb	srgb	PROPN
dti-1337	325	12	iec61966	iec61966	NOUN
dti-1337	325	13	-	-	PUNCT
dti-1337	325	14	2.1	2.1	NUM
dti-1337	325	15	)	)	PUNCT
dti-1337	325	16	/cannotembedfontpolicy	/cannotembedfontpolicy	PUNCT
dti-1337	326	1	/error	/error	INTJ
dti-1337	326	2	/compatibilitylevel	/compatibilitylevel	NOUN
dti-1337	327	1	1.4	1.4	NUM
dti-1337	327	2	/compressobjects	/compressobject	NOUN
dti-1337	327	3	/tags	/tag	VERB
dti-1337	327	4	/compresspages	/compresspage	NOUN
dti-1337	327	5	true	true	ADJ
dti-1337	327	6	/convertimagestoindexed	/convertimagestoindexed	ADJ
dti-1337	327	7	true	true	ADJ
dti-1337	327	8	/passthroughjpegimages	/passthroughjpegimage	NOUN
dti-1337	327	9	true	true	ADJ
dti-1337	327	10	/createjdffile	/createjdffile	ADJ
dti-1337	327	11	false	false	ADJ
dti-1337	327	12	/createjobticket	/createjobticket	NOUN
dti-1337	327	13	false	false	ADJ
dti-1337	327	14	/defaultrenderingintent	/defaultrenderingintent	NOUN
dti-1337	327	15	/default	/default	PUNCT
dti-1337	327	16	/detectblends	/detectblend	NOUN
dti-1337	327	17	true	true	ADJ
dti-1337	327	18	/detectcurves	/detectcurve	VERB
dti-1337	327	19	0.1000	0.1000	NUM
dti-1337	327	20	/colorconversionstrategy	/colorconversionstrategy	NOUN
dti-1337	327	21	/leavecolorunchanged	/leavecolorunchange	VERB
dti-1337	327	22	/dothumbnails	/dothumbnail	VERB
dti-1337	328	1	false	false	ADJ
dti-1337	328	2	/embedallfonts	/embedallfont	NOUN
dti-1337	328	3	true	true	ADJ
dti-1337	328	4	/embedopentype	/embedopentype	PUNCT
dti-1337	328	5	false	false	ADJ
dti-1337	328	6	/parseiccprofilesincomments	/parseiccprofilesincomment	NOUN
dti-1337	328	7	true	true	ADJ
dti-1337	328	8	/embedjoboptions	/embedjoboption	NOUN
dti-1337	328	9	true	true	ADJ
dti-1337	328	10	/dscreportinglevel	/dscreportinglevel	NOUN
dti-1337	328	11	0	0	NUM
dti-1337	328	12	/emitdscwarnings	/emitdscwarning	NOUN
dti-1337	328	13	false	false	ADJ
dti-1337	328	14	/endpage	/endpage	NOUN
dti-1337	328	15	-1	-1	NOUN
dti-1337	328	16	/imagememory	/imagememory	NUM
dti-1337	328	17	1048576	1048576	NUM
dti-1337	328	18	/lockdistillerparams	/lockdistillerparams	NOUN
dti-1337	328	19	false	false	ADJ
dti-1337	328	20	/maxsubsetpct	/maxsubsetpct	ADJ
dti-1337	328	21	100	100	NUM
dti-1337	328	22	/optimize	/optimize	NOUN
dti-1337	328	23	true	true	ADJ
dti-1337	328	24	/opm	/opm	NOUN
dti-1337	328	25	1	1	NUM
dti-1337	328	26	/parsedsccomments	/parsedsccomment	NOUN
dti-1337	328	27	true	true	ADJ
dti-1337	328	28	/parsedsccommentsfordocinfo	/parsedsccommentsfordocinfo	VERB
dti-1337	328	29	true	true	ADJ
dti-1337	328	30	/preservecopypage	/preservecopypage	NOUN
dti-1337	328	31	true	true	ADJ
dti-1337	328	32	/preservedicmykvalues	/preservedicmykvalue	NOUN
dti-1337	328	33	true	true	ADJ
dti-1337	328	34	/preserveepsinfo	/preserveepsinfo	NOUN
dti-1337	328	35	true	true	ADJ
dti-1337	328	36	/preserveflatness	/preserveflatness	NOUN
dti-1337	328	37	true	true	ADJ
dti-1337	328	38	/preservehalftoneinfo	/preservehalftoneinfo	PUNCT
dti-1337	328	39	false	false	ADJ
dti-1337	328	40	/preserveopicomments	/preserveopicomment	NOUN
dti-1337	328	41	false	false	ADJ
dti-1337	328	42	/preserveoverprintsettings	/preserveoverprintsetting	NOUN
dti-1337	328	43	true	true	ADJ
dti-1337	328	44	/startpage	/startpage	NOUN
dti-1337	328	45	1	1	NUM
dti-1337	328	46	/subsetfonts	/subsetfont	NOUN
dti-1337	328	47	true	true	ADJ
dti-1337	328	48	/transferfunctioninfo	/transferfunctioninfo	PUNCT
dti-1337	328	49	/apply	/apply	PUNCT
dti-1337	328	50	/ucrandbginfo	/ucrandbginfo	PUNCT
dti-1337	329	1	/preserve	/preserve	NOUN
dti-1337	329	2	/useprologue	/useprologue	NOUN
dti-1337	329	3	false	false	ADJ
dti-1337	329	4	/colorsettingsfile	/colorsettingsfile	NOUN
dti-1337	329	5	(	(	PUNCT
dti-1337	329	6	)	)	PUNCT
dti-1337	329	7	/alwaysembed	/alwaysembe	VERB
dti-1337	329	8	[	[	PUNCT
dti-1337	329	9	true	true	ADJ
dti-1337	329	10	]	]	PUNCT
dti-1337	329	11	/neverembed	/neverembed	PUNCT
dti-1337	330	1	[	[	PUNCT
dti-1337	330	2	true	true	ADJ
dti-1337	330	3	]	]	PUNCT
dti-1337	330	4	/antialiascolorimages	/antialiascolorimages	X
dti-1337	330	5	false	false	ADJ
dti-1337	330	6	/cropcolorimages	/cropcolorimages	PUNCT
dti-1337	330	7	true	true	ADJ
dti-1337	330	8	/colorimageminresolution	/colorimageminresolution	NOUN
dti-1337	330	9	150	150	NUM
dti-1337	330	10	/colorimageminresolutionpolicy	/colorimageminresolutionpolicy	NOUN
dti-1337	330	11	/ok	/ok	PUNCT
dti-1337	331	1	/downsamplecolorimages	/downsamplecolorimage	VERB
dti-1337	332	1	true	true	ADJ
dti-1337	332	2	/colorimagedownsampletype	/colorimagedownsampletype	PUNCT
dti-1337	332	3	/bicubic	/bicubic	NOUN
dti-1337	332	4	/colorimageresolution	/colorimageresolution	NOUN
dti-1337	333	1	300	300	NUM
dti-1337	333	2	/colorimagedepth	/colorimagedepth	PRON
dti-1337	333	3	-1	-1	INTJ
dti-1337	333	4	/colorimagemindownsampledepth	/colorimagemindownsampledepth	SYM
dti-1337	333	5	1	1	NUM
dti-1337	333	6	/colorimagedownsamplethreshold	/colorimagedownsamplethreshold	SYM
dti-1337	333	7	1.50000	1.50000	NUM
dti-1337	333	8	/encodecolorimages	/encodecolorimage	NOUN
dti-1337	333	9	true	true	ADJ
dti-1337	333	10	/colorimagefilter	/colorimagefilter	PUNCT
dti-1337	333	11	/dctencode	/dctencode	PUNCT
dti-1337	334	1	/autofiltercolorimages	/autofiltercolorimage	NOUN
dti-1337	334	2	true	true	ADJ
dti-1337	334	3	/colorimageautofilterstrategy	/colorimageautofilterstrategy	PUNCT
dti-1337	334	4	/jpeg	/jpeg	PUNCT
dti-1337	334	5	/coloracsimagedict	/coloracsimagedict	PUNCT
dti-1337	335	1	<	<	X
dti-1337	335	2	<	<	X
dti-1337	335	3	/qfactor	/qfactor	NOUN
dti-1337	335	4	0.15	0.15	NUM
dti-1337	335	5	/hsamples	/hsample	NOUN
dti-1337	336	1	[	[	X
dti-1337	336	2	1	1	NUM
dti-1337	336	3	1	1	NUM
dti-1337	336	4	1	1	NUM
dti-1337	336	5	1	1	NUM
dti-1337	336	6	]	]	PUNCT
dti-1337	336	7	/vsamples	/vsample	NOUN
dti-1337	337	1	[	[	X
dti-1337	337	2	1	1	NUM
dti-1337	337	3	1	1	NUM
dti-1337	337	4	1	1	NUM
dti-1337	337	5	1	1	NUM
dti-1337	337	6	]	]	PUNCT
dti-1337	337	7	>	>	PUNCT
dti-1337	337	8	>	>	X
dti-1337	337	9	/colorimagedict	/colorimagedict	PUNCT
dti-1337	338	1	<	<	X
dti-1337	338	2	<	<	X
dti-1337	338	3	/qfactor	/qfactor	NOUN
dti-1337	338	4	0.15	0.15	NUM
dti-1337	338	5	/hsamples	/hsample	NOUN
dti-1337	339	1	[	[	X
dti-1337	339	2	1	1	NUM
dti-1337	339	3	1	1	NUM
dti-1337	339	4	1	1	NUM
dti-1337	339	5	1	1	NUM
dti-1337	339	6	]	]	PUNCT
dti-1337	339	7	/vsamples	/vsample	NOUN
dti-1337	340	1	[	[	X
dti-1337	340	2	1	1	NUM
dti-1337	340	3	1	1	NUM
dti-1337	340	4	1	1	NUM
dti-1337	340	5	1	1	NUM
dti-1337	340	6	]	]	PUNCT
dti-1337	340	7	>	>	PUNCT
dti-1337	340	8	>	>	X
dti-1337	340	9	/jpeg2000coloracsimagedict	/jpeg2000coloracsimagedict	PUNCT
dti-1337	341	1	<	<	X
dti-1337	341	2	<	<	X
dti-1337	341	3	/tilewidth	/tilewidth	PUNCT
dti-1337	341	4	256	256	NUM
dti-1337	341	5	/tileheight	/tileheight	NUM
dti-1337	341	6	256	256	NUM
dti-1337	341	7	/quality	/quality	NOUN
dti-1337	341	8	30	30	NUM
dti-1337	341	9	>	>	PUNCT
dti-1337	341	10	>	>	X
dti-1337	341	11	/jpeg2000colorimagedict	/jpeg2000colorimagedict	PUNCT
dti-1337	341	12	<	<	X
dti-1337	341	13	<	<	X
dti-1337	341	14	/tilewidth	/tilewidth	PUNCT
dti-1337	341	15	256	256	NUM
dti-1337	341	16	/tileheight	/tileheight	NUM
dti-1337	341	17	256	256	NUM
dti-1337	341	18	/quality	/quality	NOUN
dti-1337	341	19	30	30	NUM
dti-1337	341	20	>	>	PUNCT
dti-1337	341	21	>	>	X
dti-1337	341	22	/antialiasgrayimages	/antialiasgrayimages	X
dti-1337	341	23	false	false	ADJ
dti-1337	341	24	/cropgrayimages	/cropgrayimage	NOUN
dti-1337	341	25	true	true	ADJ
dti-1337	341	26	/grayimageminresolution	/grayimageminresolution	ADV
dti-1337	341	27	150	150	NUM
dti-1337	341	28	/grayimageminresolutionpolicy	/grayimageminresolutionpolicy	NOUN
dti-1337	342	1	/ok	/ok	ADJ
dti-1337	342	2	/downsamplegrayimages	/downsamplegrayimages	PUNCT
dti-1337	343	1	true	true	ADJ
dti-1337	343	2	/grayimagedownsampletype	/grayimagedownsampletype	INTJ
dti-1337	343	3	/bicubic	/bicubic	NOUN
dti-1337	343	4	/grayimageresolution	/grayimageresolution	NOUN
dti-1337	343	5	300	300	NUM
dti-1337	343	6	/grayimagedepth	/grayimagedepth	PUNCT
dti-1337	343	7	-1	-1	PUNCT
dti-1337	343	8	/grayimagemindownsampledepth	/grayimagemindownsampledepth	PUNCT
dti-1337	344	1	2	2	NUM
dti-1337	344	2	/grayimagedownsamplethreshold	/grayimagedownsamplethreshold	NUM
dti-1337	344	3	1.50000	1.50000	NUM
dti-1337	344	4	/encodegrayimages	/encodegrayimage	NOUN
dti-1337	344	5	true	true	ADJ
dti-1337	344	6	/grayimagefilter	/grayimagefilter	NOUN
dti-1337	344	7	/dctencode	/dctencode	PUNCT
dti-1337	345	1	/autofiltergrayimages	/autofiltergrayimages	VERB
dti-1337	345	2	true	true	ADJ
dti-1337	345	3	/grayimageautofilterstrategy	/grayimageautofilterstrategy	INTJ
dti-1337	345	4	/jpeg	/jpeg	PUNCT
dti-1337	345	5	/grayacsimagedict	/grayacsimagedict	PUNCT
dti-1337	346	1	<	<	X
dti-1337	346	2	<	<	X
dti-1337	346	3	/qfactor	/qfactor	NOUN
dti-1337	346	4	0.15	0.15	NUM
dti-1337	346	5	/hsamples	/hsample	NOUN
dti-1337	347	1	[	[	X
dti-1337	347	2	1	1	NUM
dti-1337	347	3	1	1	NUM
dti-1337	347	4	1	1	NUM
dti-1337	347	5	1	1	NUM
dti-1337	347	6	]	]	PUNCT
dti-1337	347	7	/vsamples	/vsample	NOUN
dti-1337	348	1	[	[	X
dti-1337	348	2	1	1	NUM
dti-1337	348	3	1	1	NUM
dti-1337	348	4	1	1	NUM
dti-1337	348	5	1	1	NUM
dti-1337	348	6	]	]	PUNCT
dti-1337	348	7	>	>	PUNCT
dti-1337	348	8	>	>	X
dti-1337	348	9	/grayimagedict	/grayimagedict	PUNCT
dti-1337	349	1	<	<	X
dti-1337	349	2	<	<	X
dti-1337	349	3	/qfactor	/qfactor	NOUN
dti-1337	349	4	0.15	0.15	NUM
dti-1337	349	5	/hsamples	/hsample	NOUN
dti-1337	350	1	[	[	X
dti-1337	350	2	1	1	NUM
dti-1337	350	3	1	1	NUM
dti-1337	350	4	1	1	NUM
dti-1337	350	5	1	1	NUM
dti-1337	350	6	]	]	PUNCT
dti-1337	350	7	/vsamples	/vsample	NOUN
dti-1337	351	1	[	[	X
dti-1337	351	2	1	1	NUM
dti-1337	351	3	1	1	NUM
dti-1337	351	4	1	1	NUM
dti-1337	351	5	1	1	NUM
dti-1337	351	6	]	]	PUNCT
dti-1337	351	7	>	>	X
dti-1337	351	8	>	>	X
dti-1337	351	9	/jpeg2000grayacsimagedict	/jpeg2000grayacsimagedict	PUNCT
dti-1337	352	1	<	<	X
dti-1337	352	2	<	<	X
dti-1337	352	3	/tilewidth	/tilewidth	PUNCT
dti-1337	352	4	256	256	NUM
dti-1337	352	5	/tileheight	/tileheight	NUM
dti-1337	352	6	256	256	NUM
dti-1337	352	7	/quality	/quality	NOUN
dti-1337	352	8	30	30	NUM
dti-1337	352	9	>	>	PUNCT
dti-1337	352	10	>	>	X
dti-1337	352	11	/jpeg2000grayimagedict	/jpeg2000grayimagedict	PUNCT
dti-1337	352	12	<	<	X
dti-1337	352	13	<	<	X
dti-1337	352	14	/tilewidth	/tilewidth	PUNCT
dti-1337	352	15	256	256	NUM
dti-1337	352	16	/tileheight	/tileheight	NUM
dti-1337	352	17	256	256	NUM
dti-1337	352	18	/quality	/quality	NOUN
dti-1337	352	19	30	30	NUM
dti-1337	352	20	>	>	PUNCT
dti-1337	352	21	>	>	X
dti-1337	352	22	/antialiasmonoimages	/antialiasmonoimage	NOUN
dti-1337	352	23	false	false	ADJ
dti-1337	352	24	/cropmonoimages	/cropmonoimage	NOUN
dti-1337	352	25	true	true	ADJ
dti-1337	352	26	/monoimageminresolution	/monoimageminresolution	NUM
dti-1337	352	27	1200	1200	NUM
dti-1337	352	28	/monoimageminresolutionpolicy	/monoimageminresolutionpolicy	PUNCT
dti-1337	353	1	/ok	/ok	PROPN
dti-1337	353	2	/downsamplemonoimages	/downsamplemonoimage	VERB
dti-1337	354	1	true	true	ADJ
dti-1337	354	2	/monoimagedownsampletype	/monoimagedownsampletype	PUNCT
dti-1337	354	3	/bicubic	/bicubic	NOUN
dti-1337	354	4	/monoimageresolution	/monoimageresolution	NOUN
dti-1337	354	5	1200	1200	NUM
dti-1337	354	6	/monoimagedepth	/monoimagedepth	PRON
dti-1337	354	7	-1	-1	PUNCT
dti-1337	355	1	/monoimagedownsamplethreshold	/monoimagedownsamplethreshold	PUNCT
dti-1337	355	2	1.50000	1.50000	NUM
dti-1337	355	3	/encodemonoimages	/encodemonoimage	NOUN
dti-1337	355	4	true	true	ADJ
dti-1337	355	5	/monoimagefilter	/monoimagefilter	ADP
dti-1337	355	6	/ccittfaxencode	/ccittfaxencode	INTJ
dti-1337	355	7	/monoimagedict	/monoimagedict	PUNCT
dti-1337	356	1	<	<	X
dti-1337	356	2	<	<	X
dti-1337	356	3	/k	/k	PUNCT
dti-1337	356	4	-1	-1	INTJ
dti-1337	356	5	>	>	PUNCT
dti-1337	356	6	>	>	X
dti-1337	356	7	/allowpsxobjects	/allowpsxobjects	PROPN
dti-1337	356	8	false	false	ADJ
dti-1337	356	9	/checkcompliance	/checkcompliance	NOUN
dti-1337	356	10	[	[	PUNCT
dti-1337	356	11	/none	/none	X
dti-1337	356	12	]	]	PUNCT
dti-1337	356	13	/pdfx1acheck	/pdfx1acheck	PUNCT
dti-1337	356	14	false	false	ADJ
dti-1337	356	15	/pdfx3check	/pdfx3check	PUNCT
dti-1337	356	16	false	false	ADJ
dti-1337	356	17	/pdfxcompliantpdfonly	/pdfxcompliantpdfonly	ADV
dti-1337	356	18	false	false	ADJ
dti-1337	356	19	/pdfxnotrimboxerror	/pdfxnotrimboxerror	NOUN
dti-1337	356	20	true	true	ADJ
dti-1337	356	21	/pdfxtrimboxtomediaboxoffset	/pdfxtrimboxtomediaboxoffset	NOUN
dti-1337	356	22	[	[	PUNCT
dti-1337	356	23	0.00000	0.00000	NUM
dti-1337	356	24	0.00000	0.00000	NUM
dti-1337	356	25	0.00000	0.00000	NUM
dti-1337	356	26	0.00000	0.00000	NUM
dti-1337	356	27	]	]	PUNCT
dti-1337	356	28	/pdfxsetbleedboxtomediabox	/pdfxsetbleedboxtomediabox	PUNCT
dti-1337	357	1	true	true	ADJ
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dti-1337	369	4	/enu	/enu	PROPN
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dti-1337	369	12	setdistillerparams	setdistillerparam	NOUN
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dti-1337	370	3	/hwresolution	/hwresolution	NOUN
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dti-1337	372	7	setpagedevice	setpagedevice	PROPN