id	sid	tid	token	lemma	pos
dti-1349	1	1	drug	drug	NOUN
dti-1349	1	2	target	target	NOUN
dti-1349	1	3	insights	insight	NOUN
dti-1349	1	4	2013:7	2013:7	NUM
dti-1349	1	5	27–34	27–34	NUM
dti-1349	1	6	doi	doi	NOUN
dti-1349	1	7	:	:	PUNCT
dti-1349	1	8	10.4137	10.4137	NUM
dti-1349	1	9	/	/	SYM
dti-1349	1	10	dti.s12519	dti.s12519	NOUN
dti-1349	1	11	this	this	DET
dti-1349	1	12	article	article	NOUN
dti-1349	1	13	is	be	AUX
dti-1349	1	14	available	available	ADJ
dti-1349	1	15	from	from	ADP
dti-1349	1	16	http://www.la-press.com	http://www.la-press.com	X
dti-1349	1	17	.	.	PUNCT
dti-1349	2	1	©	©	ADP
dti-1349	2	2	the	the	DET
dti-1349	2	3	author(s	author(s	PROPN
dti-1349	2	4	)	)	PUNCT
dti-1349	2	5	,	,	PUNCT
dti-1349	2	6	publisher	publisher	NOUN
dti-1349	2	7	and	and	CCONJ
dti-1349	2	8	licensee	licensee	PROPN
dti-1349	2	9	libertas	libertas	PROPN
dti-1349	2	10	academica	academica	PROPN
dti-1349	2	11	ltd	ltd	PROPN
dti-1349	2	12	.	.	PUNCT
dti-1349	3	1	this	this	PRON
dti-1349	3	2	is	be	AUX
dti-1349	3	3	an	an	DET
dti-1349	3	4	open	open	ADJ
dti-1349	3	5	access	access	NOUN
dti-1349	3	6	article	article	NOUN
dti-1349	3	7	published	publish	VERB
dti-1349	3	8	under	under	ADP
dti-1349	3	9	the	the	DET
dti-1349	3	10	creative	creative	ADJ
dti-1349	3	11	commons	common	NOUN
dti-1349	3	12	cc	cc	NOUN
dti-1349	3	13	-	-	PUNCT
dti-1349	3	14	by	by	ADP
dti-1349	3	15	-	-	PUNCT
dti-1349	3	16	nc	nc	PROPN
dti-1349	3	17	3.0	3.0	NUM
dti-1349	3	18	license	license	NOUN
dti-1349	3	19	.	.	PUNCT
dti-1349	4	1	open	open	ADJ
dti-1349	4	2	access	access	NOUN
dti-1349	4	3	full	full	ADJ
dti-1349	4	4	open	open	ADJ
dti-1349	4	5	access	access	NOUN
dti-1349	4	6	to	to	ADP
dti-1349	4	7	this	this	PRON
dti-1349	4	8	and	and	CCONJ
dti-1349	4	9	thousands	thousand	NOUN
dti-1349	4	10	of	of	ADP
dti-1349	4	11	other	other	ADJ
dti-1349	4	12	papers	paper	NOUN
dti-1349	4	13	at	at	ADP
dti-1349	4	14	http://www.la-press.com	http://www.la-press.com	X
dti-1349	4	15	.	.	PUNCT
dti-1349	5	1	drug	drug	NOUN
dti-1349	5	2	target	target	NOUN
dti-1349	5	3	insights	insight	NOUN
dti-1349	5	4	s	s	PART
dti-1349	5	5	h	h	NOUN
dti-1349	6	1	o	o	NOUN
dti-1349	6	2	r	r	NOUN
dti-1349	6	3	t	t	NOUN
dti-1349	6	4	r	r	NOUN
dti-1349	6	5	e	e	NOUN
dti-1349	6	6	v	v	NOUN
dti-1349	7	1	i	i	NOUN
dti-1349	7	2	e	e	PROPN
dti-1349	7	3	w	w	PROPN
dti-1349	7	4	drug	drug	NOUN
dti-1349	7	5	target	target	NOUN
dti-1349	7	6	insights	insight	NOUN
dti-1349	7	7	2013:7	2013:7	NUM
dti-1349	7	8	27	27	NUM
dti-1349	7	9	p	p	ADJ
dti-1349	7	10	-	-	PUNCT
dti-1349	7	11	glycoprotein	glycoprotein	NOUN
dti-1349	7	12	inhibition	inhibition	NOUN
dti-1349	7	13	for	for	ADP
dti-1349	7	14	optimal	optimal	ADJ
dti-1349	7	15	drug	drug	NOUN
dti-1349	7	16	delivery	delivery	NOUN
dti-1349	7	17	md	md	PROPN
dti-1349	7	18	.	.	PROPN
dti-1349	8	1	lutful	lutful	PROPN
dti-1349	8	2	amin	amin	PROPN
dti-1349	8	3	department	department	PROPN
dti-1349	8	4	of	of	ADP
dti-1349	8	5	pharmacy	pharmacy	PROPN
dti-1349	8	6	,	,	PUNCT
dti-1349	8	7	stamford	stamford	PROPN
dti-1349	8	8	university	university	PROPN
dti-1349	8	9	bangladesh	bangladesh	PROPN
dti-1349	8	10	,	,	PUNCT
dti-1349	8	11	dhaka	dhaka	PROPN
dti-1349	8	12	,	,	PUNCT
dti-1349	8	13	bangladesh	bangladesh	PROPN
dti-1349	8	14	.	.	PUNCT
dti-1349	9	1	corresponding	correspond	VERB
dti-1349	9	2	author	author	NOUN
dti-1349	9	3	email	email	NOUN
dti-1349	9	4	:	:	PUNCT
dti-1349	9	5	lutful_amin@yahoo.com	lutful_amin@yahoo.com	X
dti-1349	9	6	abstract	abstract	NOUN
dti-1349	9	7	:	:	PUNCT
dti-1349	9	8	p	p	X
dti-1349	9	9	-	-	PUNCT
dti-1349	9	10	glycoprotein	glycoprotein	NOUN
dti-1349	9	11	(	(	PUNCT
dti-1349	9	12	p	p	NOUN
dti-1349	9	13	-	-	PUNCT
dti-1349	9	14	gp	gp	NOUN
dti-1349	9	15	)	)	PUNCT
dti-1349	9	16	,	,	PUNCT
dti-1349	9	17	an	an	DET
dti-1349	9	18	efflux	efflux	ADJ
dti-1349	9	19	membrane	membrane	NOUN
dti-1349	9	20	transporter	transporter	NOUN
dti-1349	9	21	,	,	PUNCT
dti-1349	9	22	is	be	AUX
dti-1349	9	23	widely	widely	ADV
dti-1349	9	24	distributed	distribute	VERB
dti-1349	9	25	throughout	throughout	ADP
dti-1349	9	26	the	the	DET
dti-1349	9	27	body	body	NOUN
dti-1349	9	28	and	and	CCONJ
dti-1349	9	29	is	be	AUX
dti-1349	9	30	responsible	responsible	ADJ
dti-1349	9	31	for	for	ADP
dti-1349	9	32	limiting	limit	VERB
dti-1349	9	33	cellular	cellular	ADJ
dti-1349	9	34	uptake	uptake	NOUN
dti-1349	9	35	and	and	CCONJ
dti-1349	9	36	the	the	DET
dti-1349	9	37	distribution	distribution	NOUN
dti-1349	9	38	of	of	ADP
dti-1349	9	39	xenobiotics	xenobiotic	NOUN
dti-1349	9	40	and	and	CCONJ
dti-1349	9	41	toxic	toxic	ADJ
dti-1349	9	42	substances	substance	NOUN
dti-1349	9	43	.	.	PUNCT
dti-1349	10	1	hundreds	hundred	NOUN
dti-1349	10	2	of	of	ADP
dti-1349	10	3	structurally	structurally	ADV
dti-1349	10	4	diverse	diverse	ADJ
dti-1349	10	5	therapeutic	therapeutic	ADJ
dti-1349	10	6	agents	agent	NOUN
dti-1349	10	7	are	be	AUX
dti-1349	10	8	substrates	substrate	NOUN
dti-1349	10	9	to	to	ADP
dti-1349	10	10	it	it	PRON
dti-1349	10	11	and	and	CCONJ
dti-1349	10	12	it	it	PRON
dti-1349	10	13	impedes	impede	VERB
dti-1349	10	14	the	the	DET
dti-1349	10	15	absorption	absorption	NOUN
dti-1349	10	16	,	,	PUNCT
dti-1349	10	17	permeability	permeability	NOUN
dti-1349	10	18	,	,	PUNCT
dti-1349	10	19	and	and	CCONJ
dti-1349	10	20	retention	retention	NOUN
dti-1349	10	21	of	of	ADP
dti-1349	10	22	the	the	DET
dti-1349	10	23	drugs	drug	NOUN
dti-1349	10	24	,	,	PUNCT
dti-1349	10	25	extruding	extrude	VERB
dti-1349	10	26	them	they	PRON
dti-1349	10	27	out	out	ADP
dti-1349	10	28	of	of	ADP
dti-1349	10	29	the	the	DET
dti-1349	10	30	cells	cell	NOUN
dti-1349	10	31	.	.	PUNCT
dti-1349	11	1	it	it	PRON
dti-1349	11	2	is	be	AUX
dti-1349	11	3	overexpressed	overexpresse	VERB
dti-1349	11	4	in	in	ADP
dti-1349	11	5	cancer	cancer	NOUN
dti-1349	11	6	cells	cell	NOUN
dti-1349	11	7	and	and	CCONJ
dti-1349	11	8	accountable	accountable	ADJ
dti-1349	11	9	for	for	ADP
dti-1349	11	10	obstructing	obstruct	VERB
dti-1349	11	11	cell	cell	NOUN
dti-1349	11	12	internalization	internalization	NOUN
dti-1349	11	13	of	of	ADP
dti-1349	11	14	chemotherapeutic	chemotherapeutic	ADJ
dti-1349	11	15	agents	agent	NOUN
dti-1349	11	16	and	and	CCONJ
dti-1349	11	17	for	for	ADP
dti-1349	11	18	developing	develop	VERB
dti-1349	11	19	transporter	transporter	NOUN
dti-1349	11	20	mediated	mediate	VERB
dti-1349	11	21	resistance	resistance	NOUN
dti-1349	11	22	by	by	ADP
dti-1349	11	23	cancer	cancer	NOUN
dti-1349	11	24	cells	cell	NOUN
dti-1349	11	25	during	during	ADP
dti-1349	11	26	anti	anti	ADJ
dti-1349	11	27	-	-	ADJ
dti-1349	11	28	tumor	tumor	ADJ
dti-1349	11	29	treatments	treatment	NOUN
dti-1349	11	30	.	.	PUNCT
dti-1349	12	1	as	as	SCONJ
dti-1349	12	2	it	it	PRON
dti-1349	12	3	jeopardizes	jeopardize	VERB
dti-1349	12	4	the	the	DET
dti-1349	12	5	success	success	NOUN
dti-1349	12	6	of	of	ADP
dti-1349	12	7	drug	drug	NOUN
dti-1349	12	8	delivery	delivery	NOUN
dti-1349	12	9	and	and	CCONJ
dti-1349	12	10	cancer	cancer	NOUN
dti-1349	12	11	targeting	targeting	NOUN
dti-1349	12	12	,	,	PUNCT
dti-1349	12	13	strategies	strategy	NOUN
dti-1349	12	14	are	be	AUX
dti-1349	12	15	being	be	AUX
dti-1349	12	16	developed	develop	VERB
dti-1349	12	17	to	to	PART
dti-1349	12	18	overcome	overcome	VERB
dti-1349	12	19	p	p	NOUN
dti-1349	12	20	-	-	PUNCT
dti-1349	12	21	gp	gp	NOUN
dti-1349	12	22	mediated	mediate	VERB
dti-1349	12	23	drug	drug	NOUN
dti-1349	12	24	transport	transport	NOUN
dti-1349	12	25	.	.	PUNCT
dti-1349	13	1	this	this	DET
dti-1349	13	2	concise	concise	ADJ
dti-1349	13	3	review	review	NOUN
dti-1349	13	4	represents	represent	VERB
dti-1349	13	5	a	a	DET
dti-1349	13	6	brief	brief	ADJ
dti-1349	13	7	discussion	discussion	NOUN
dti-1349	13	8	on	on	ADP
dti-1349	13	9	p	p	NOUN
dti-1349	13	10	-	-	PUNCT
dti-1349	13	11	gp	gp	NOUN
dti-1349	13	12	mediated	mediate	VERB
dti-1349	13	13	drug	drug	NOUN
dti-1349	13	14	transport	transport	NOUN
dti-1349	13	15	and	and	CCONJ
dti-1349	13	16	how	how	SCONJ
dti-1349	13	17	it	it	PRON
dti-1349	13	18	hinders	hinder	VERB
dti-1349	13	19	the	the	DET
dti-1349	13	20	success	success	NOUN
dti-1349	13	21	of	of	ADP
dti-1349	13	22	various	various	ADJ
dti-1349	13	23	therapies	therapy	NOUN
dti-1349	13	24	.	.	PUNCT
dti-1349	14	1	its	its	PRON
dti-1349	14	2	main	main	ADJ
dti-1349	14	3	focus	focus	NOUN
dti-1349	14	4	is	be	AUX
dti-1349	14	5	on	on	ADP
dti-1349	14	6	various	various	ADJ
dti-1349	14	7	strategies	strategy	NOUN
dti-1349	14	8	used	use	VERB
dti-1349	14	9	to	to	PART
dti-1349	14	10	tackle	tackle	VERB
dti-1349	14	11	this	this	DET
dti-1349	14	12	curb	curb	NOUN
dti-1349	14	13	in	in	ADP
dti-1349	14	14	the	the	DET
dti-1349	14	15	field	field	NOUN
dti-1349	14	16	of	of	ADP
dti-1349	14	17	drug	drug	NOUN
dti-1349	14	18	delivery	delivery	NOUN
dti-1349	14	19	and	and	CCONJ
dti-1349	14	20	targeting	targeting	NOUN
dti-1349	14	21	.	.	PUNCT
dti-1349	15	1	keywords	keyword	NOUN
dti-1349	15	2	:	:	PUNCT
dti-1349	15	3	p	p	X
dti-1349	15	4	-	-	PUNCT
dti-1349	15	5	glycoprotein	glycoprotein	NOUN
dti-1349	15	6	,	,	PUNCT
dti-1349	15	7	drug	drug	NOUN
dti-1349	15	8	efflux	efflux	NOUN
dti-1349	15	9	,	,	PUNCT
dti-1349	15	10	bioavailability	bioavailability	NOUN
dti-1349	15	11	,	,	PUNCT
dti-1349	15	12	drug	drug	NOUN
dti-1349	15	13	delivery	delivery	NOUN
dti-1349	15	14	,	,	PUNCT
dti-1349	15	15	drug	drug	NOUN
dti-1349	15	16	resistance	resistance	NOUN
dti-1349	15	17	,	,	PUNCT
dti-1349	15	18	p	p	NOUN
dti-1349	15	19	-	-	PUNCT
dti-1349	15	20	glycoprotein	glycoprotein	NOUN
dti-1349	15	21	inhibitor	inhibitor	NOUN
dti-1349	15	22	http://dx.doi.org/10.4137/dti.s12519	http://dx.doi.org/10.4137/dti.s12519	NOUN
dti-1349	15	23	http://www.la-press.com	http://www.la-press.com	X
dti-1349	15	24	http://www.la-press.com	http://www.la-press.com	X
dti-1349	15	25	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1349	15	26	http://www.la-press.com	http://www.la-press.com	X
dti-1349	15	27	mailto:lutful_amin@yahoo.com	mailto:lutful_amin@yahoo.com	PROPN
dti-1349	15	28	amin	amin	PROPN
dti-1349	15	29	28	28	NUM
dti-1349	15	30	drug	drug	NOUN
dti-1349	15	31	target	target	NOUN
dti-1349	15	32	insights	insight	NOUN
dti-1349	15	33	2013:7	2013:7	NUM
dti-1349	15	34	introduction	introduction	NOUN
dti-1349	15	35	p	p	NOUN
dti-1349	15	36	-	-	PUNCT
dti-1349	15	37	glycoprotein	glycoprotein	NOUN
dti-1349	15	38	(	(	PUNCT
dti-1349	15	39	p	p	NOUN
dti-1349	15	40	-	-	PUNCT
dti-1349	15	41	gp	gp	NOUN
dti-1349	15	42	)	)	PUNCT
dti-1349	15	43	is	be	AUX
dti-1349	15	44	one	one	NUM
dti-1349	15	45	of	of	ADP
dti-1349	15	46	the	the	DET
dti-1349	15	47	first	first	ADJ
dti-1349	15	48	members	member	NOUN
dti-1349	15	49	of	of	ADP
dti-1349	15	50	the	the	DET
dti-1349	15	51	atp	atp	NOUN
dti-1349	15	52	-	-	PUNCT
dti-1349	15	53	binding	bind	VERB
dti-1349	15	54	cassette	cassette	NOUN
dti-1349	15	55	(	(	PUNCT
dti-1349	15	56	abc	abc	PROPN
dti-1349	15	57	)	)	PUNCT
dti-1349	15	58	transporter	transporter	NOUN
dti-1349	15	59	which	which	PRON
dti-1349	15	60	acts	act	VERB
dti-1349	15	61	as	as	ADP
dti-1349	15	62	a	a	DET
dti-1349	15	63	physiological	physiological	ADJ
dti-1349	15	64	barrier	barrier	NOUN
dti-1349	15	65	by	by	ADP
dti-1349	15	66	extruding	extrude	VERB
dti-1349	15	67	toxins	toxin	NOUN
dti-1349	15	68	and	and	CCONJ
dti-1349	15	69	xenobiotics	xenobiotic	NOUN
dti-1349	15	70	out	out	ADP
dti-1349	15	71	of	of	ADP
dti-1349	15	72	cells.1,2	cells.1,2	PROPN
dti-1349	15	73	it	it	PRON
dti-1349	15	74	is	be	AUX
dti-1349	15	75	being	be	AUX
dti-1349	15	76	extensively	extensively	ADV
dti-1349	15	77	studied	study	VERB
dti-1349	15	78	and	and	CCONJ
dti-1349	15	79	experimented	experiment	VERB
dti-1349	15	80	upon	upon	SCONJ
dti-1349	15	81	recently	recently	ADV
dti-1349	15	82	and	and	CCONJ
dti-1349	15	83	is	be	AUX
dti-1349	15	84	gaining	gain	VERB
dti-1349	15	85	much	much	ADJ
dti-1349	15	86	importance	importance	NOUN
dti-1349	15	87	in	in	ADP
dti-1349	15	88	numerous	numerous	ADJ
dti-1349	15	89	researches	research	NOUN
dti-1349	15	90	.	.	PUNCT
dti-1349	16	1	p	p	X
dti-1349	16	2	-	-	PUNCT
dti-1349	16	3	gp	gp	NOUN
dti-1349	16	4	is	be	AUX
dti-1349	16	5	primarily	primarily	ADV
dti-1349	16	6	found	find	VERB
dti-1349	16	7	in	in	ADP
dti-1349	16	8	epithelial	epithelial	ADJ
dti-1349	16	9	cells	cell	NOUN
dti-1349	16	10	which	which	PRON
dti-1349	16	11	have	have	VERB
dti-1349	16	12	the	the	DET
dti-1349	16	13	excretory	excretory	NOUN
dti-1349	16	14	roles	role	NOUN
dti-1349	16	15	including	include	VERB
dti-1349	16	16	apical	apical	ADJ
dti-1349	16	17	surface	surface	NOUN
dti-1349	16	18	of	of	ADP
dti-1349	16	19	epithelial	epithelial	ADJ
dti-1349	16	20	cells	cell	NOUN
dti-1349	16	21	lining	line	VERB
dti-1349	16	22	the	the	DET
dti-1349	16	23	colon	colon	NOUN
dti-1349	16	24	,	,	PUNCT
dti-1349	16	25	small	small	ADJ
dti-1349	16	26	intestine	intestine	NOUN
dti-1349	16	27	,	,	PUNCT
dti-1349	16	28	pancreatic	pancreatic	ADJ
dti-1349	16	29	ductules	ductule	NOUN
dti-1349	16	30	,	,	PUNCT
dti-1349	16	31	bile	bile	NOUN
dti-1349	16	32	ductules	ductule	NOUN
dti-1349	16	33	,	,	PUNCT
dti-1349	16	34	kidney	kidney	NOUN
dti-1349	16	35	proximal	proximal	ADJ
dti-1349	16	36	tubules	tubule	NOUN
dti-1349	16	37	,	,	PUNCT
dti-1349	16	38	and	and	CCONJ
dti-1349	16	39	the	the	DET
dti-1349	16	40	adrenal	adrenal	NOUN
dti-1349	17	1	gland.3–5	gland.3–5	INTJ
dti-1349	17	2	it	it	PRON
dti-1349	17	3	is	be	AUX
dti-1349	17	4	also	also	ADV
dti-1349	17	5	located	locate	VERB
dti-1349	17	6	in	in	ADP
dti-1349	17	7	the	the	DET
dti-1349	17	8	endothelial	endothelial	ADJ
dti-1349	17	9	cells	cell	NOUN
dti-1349	17	10	of	of	ADP
dti-1349	17	11	the	the	DET
dti-1349	17	12	blood	blood	NOUN
dti-1349	17	13	brain	brain	NOUN
dti-1349	17	14	barrier	barrier	NOUN
dti-1349	17	15	(	(	PUNCT
dti-1349	17	16	bbb).6	bbb).6	ADP
dti-1349	17	17	the	the	DET
dti-1349	17	18	transporter	transporter	NOUN
dti-1349	17	19	is	be	AUX
dti-1349	17	20	overexpressed	overexpresse	VERB
dti-1349	17	21	on	on	ADP
dti-1349	17	22	the	the	DET
dti-1349	17	23	surface	surface	NOUN
dti-1349	17	24	of	of	ADP
dti-1349	17	25	many	many	ADJ
dti-1349	17	26	neoplastic	neoplastic	ADJ
dti-1349	17	27	cells	cell	NOUN
dti-1349	17	28	and	and	CCONJ
dti-1349	17	29	restricts	restrict	VERB
dti-1349	17	30	cell	cell	NOUN
dti-1349	17	31	entry	entry	NOUN
dti-1349	17	32	.	.	PUNCT
dti-1349	18	1	the	the	DET
dti-1349	18	2	role	role	NOUN
dti-1349	18	3	of	of	ADP
dti-1349	18	4	p	p	NOUN
dti-1349	18	5	-	-	PUNCT
dti-1349	18	6	gp	gp	NOUN
dti-1349	18	7	is	be	AUX
dti-1349	18	8	likely	likely	ADJ
dti-1349	18	9	to	to	PART
dti-1349	18	10	protect	protect	VERB
dti-1349	18	11	these	these	DET
dti-1349	18	12	susceptible	susceptible	ADJ
dti-1349	18	13	organs	organ	NOUN
dti-1349	18	14	from	from	ADP
dti-1349	18	15	toxic	toxic	ADJ
dti-1349	18	16	compounds	compound	NOUN
dti-1349	18	17	,	,	PUNCT
dti-1349	18	18	preventing	prevent	VERB
dti-1349	18	19	them	they	PRON
dti-1349	18	20	to	to	PART
dti-1349	18	21	enter	enter	VERB
dti-1349	18	22	the	the	DET
dti-1349	18	23	cytosol	cytosol	NOUN
dti-1349	18	24	and	and	CCONJ
dti-1349	18	25	extrude	extrude	VERB
dti-1349	18	26	them	they	PRON
dti-1349	18	27	to	to	ADP
dti-1349	18	28	the	the	DET
dti-1349	18	29	exterior.7	exterior.7	PRON
dti-1349	18	30	thus	thus	ADV
dti-1349	18	31	it	it	PRON
dti-1349	18	32	also	also	ADV
dti-1349	18	33	enhances	enhance	VERB
dti-1349	18	34	the	the	DET
dti-1349	18	35	secretion	secretion	NOUN
dti-1349	18	36	of	of	ADP
dti-1349	18	37	metabolites	metabolite	NOUN
dti-1349	18	38	and	and	CCONJ
dti-1349	18	39	xenobiotics	xenobiotic	NOUN
dti-1349	18	40	into	into	ADP
dti-1349	18	41	bile	bile	NOUN
dti-1349	18	42	,	,	PUNCT
dti-1349	18	43	urine	urine	NOUN
dti-1349	18	44	,	,	PUNCT
dti-1349	18	45	and	and	CCONJ
dti-1349	18	46	the	the	DET
dti-1349	18	47	lumen	luman	NOUN
dti-1349	18	48	of	of	ADP
dti-1349	18	49	gastrointestinal	gastrointestinal	ADJ
dti-1349	18	50	tract.1	tract.1	PROPN
dti-1349	18	51	p	p	NOUN
dti-1349	18	52	-	-	PUNCT
dti-1349	18	53	gp	gp	NOUN
dti-1349	18	54	in	in	ADP
dti-1349	18	55	human	human	ADJ
dti-1349	18	56	forms	form	NOUN
dti-1349	18	57	a	a	DET
dti-1349	18	58	small	small	ADJ
dti-1349	18	59	gene	gene	NOUN
dti-1349	18	60	family	family	NOUN
dti-1349	18	61	with	with	ADP
dti-1349	18	62	two	two	NUM
dti-1349	18	63	isoforms	isoform	NOUN
dti-1349	18	64	.	.	PUNCT
dti-1349	19	1	the	the	DET
dti-1349	19	2	class	class	NOUN
dti-1349	19	3	i	i	PRON
dti-1349	19	4	isoform	isoform	VERB
dti-1349	19	5	(	(	PUNCT
dti-1349	19	6	mdr1	mdr1	PROPN
dti-1349	19	7	/	/	SYM
dti-1349	19	8	abcb1	abcb1	PROPN
dti-1349	19	9	)	)	PUNCT
dti-1349	19	10	is	be	AUX
dti-1349	19	11	a	a	DET
dti-1349	19	12	drug	drug	NOUN
dti-1349	19	13	transporter	transporter	NOUN
dti-1349	19	14	while	while	SCONJ
dti-1349	19	15	the	the	DET
dti-1349	19	16	class	class	NOUN
dti-1349	19	17	ii	ii	PROPN
dti-1349	19	18	isoform	isoform	NOUN
dti-1349	19	19	(	(	PUNCT
dti-1349	19	20	mdr2/3/	mdr2/3/	PROPN
dti-1349	19	21	abcb4	abcb4	PROPN
dti-1349	19	22	)	)	PUNCT
dti-1349	19	23	carries	carry	VERB
dti-1349	19	24	out	out	ADP
dti-1349	19	25	export	export	NOUN
dti-1349	19	26	of	of	ADP
dti-1349	19	27	phosphatidylcholine	phosphatidylcholine	NOUN
dti-1349	19	28	into	into	ADP
dti-1349	19	29	the	the	DET
dti-1349	19	30	bile.2,8	bile.2,8	PROPN
dti-1349	19	31	a	a	DET
dti-1349	19	32	single	single	ADJ
dti-1349	19	33	p	p	NOUN
dti-1349	19	34	-	-	PUNCT
dti-1349	19	35	gp	gp	NOUN
dti-1349	19	36	molecule	molecule	NOUN
dti-1349	19	37	can	can	AUX
dti-1349	19	38	recognize	recognize	VERB
dti-1349	19	39	and	and	CCONJ
dti-1349	19	40	transport	transport	VERB
dti-1349	19	41	numerous	numerous	ADJ
dti-1349	19	42	drugs	drug	NOUN
dti-1349	19	43	with	with	ADP
dti-1349	19	44	a	a	DET
dti-1349	19	45	wide	wide	ADJ
dti-1349	19	46	range	range	NOUN
dti-1349	19	47	of	of	ADP
dti-1349	19	48	chemical	chemical	NOUN
dti-1349	19	49	structures	structure	NOUN
dti-1349	19	50	,	,	PUNCT
dti-1349	19	51	ranging	range	VERB
dti-1349	19	52	from	from	ADP
dti-1349	19	53	a	a	DET
dti-1349	19	54	molecular	molecular	ADJ
dti-1349	19	55	weight	weight	NOUN
dti-1349	19	56	of	of	ADP
dti-1349	19	57	250	250	NUM
dti-1349	19	58	g	g	NOUN
dti-1349	19	59	/	/	SYM
dti-1349	19	60	mol	mol	NOUN
dti-1349	19	61	(	(	PUNCT
dti-1349	19	62	cimetidine	cimetidine	NOUN
dti-1349	19	63	)	)	PUNCT
dti-1349	19	64	to	to	ADP
dti-1349	19	65	1202	1202	NUM
dti-1349	19	66	g	g	NOUN
dti-1349	19	67	/	/	SYM
dti-1349	19	68	mol	mol	PROPN
dti-1349	19	69	(	(	PUNCT
dti-1349	19	70	cyclosporin).9	cyclosporin).9	PROPN
dti-1349	19	71	p	p	NOUN
dti-1349	19	72	-	-	PUNCT
dti-1349	19	73	gp	gp	NOUN
dti-1349	19	74	can	can	AUX
dti-1349	19	75	extrude	extrude	VERB
dti-1349	19	76	a	a	DET
dti-1349	19	77	wide	wide	ADJ
dti-1349	19	78	range	range	NOUN
dti-1349	19	79	of	of	ADP
dti-1349	19	80	structurally	structurally	ADV
dti-1349	19	81	diverse	diverse	ADJ
dti-1349	19	82	compounds	compound	NOUN
dti-1349	19	83	out	out	ADP
dti-1349	19	84	of	of	ADP
dti-1349	19	85	the	the	DET
dti-1349	19	86	cells	cell	NOUN
dti-1349	19	87	.	.	PUNCT
dti-1349	20	1	hundreds	hundred	NOUN
dti-1349	20	2	of	of	ADP
dti-1349	20	3	substrates	substrate	NOUN
dti-1349	20	4	(	(	PUNCT
dti-1349	20	5	usually	usually	ADV
dti-1349	20	6	hydrophobic	hydrophobic	NOUN
dti-1349	20	7	)	)	PUNCT
dti-1349	20	8	interact	interact	VERB
dti-1349	20	9	with	with	ADP
dti-1349	20	10	this	this	DET
dti-1349	20	11	atp	atp	NOUN
dti-1349	20	12	dependent	dependent	ADJ
dti-1349	20	13	transporter	transporter	NOUN
dti-1349	20	14	including	include	VERB
dti-1349	20	15	anticancer	anticancer	NOUN
dti-1349	20	16	agents	agent	NOUN
dti-1349	20	17	,	,	PUNCT
dti-1349	20	18	immunosuppressants	immunosuppressant	NOUN
dti-1349	20	19	,	,	PUNCT
dti-1349	20	20	steroid	steroid	NOUN
dti-1349	20	21	hormones	hormone	NOUN
dti-1349	20	22	,	,	PUNCT
dti-1349	20	23	calcium	calcium	NOUN
dti-1349	20	24	channel	channel	NOUN
dti-1349	20	25	blockers	blocker	NOUN
dti-1349	20	26	,	,	PUNCT
dti-1349	20	27	beta	beta	NOUN
dti-1349	20	28	-	-	PUNCT
dti-1349	20	29	adrenoreceptor	adrenoreceptor	NOUN
dti-1349	20	30	blockers	blocker	NOUN
dti-1349	20	31	,	,	PUNCT
dti-1349	20	32	cardiac	cardiac	ADJ
dti-1349	20	33	glycosides	glycoside	NOUN
dti-1349	20	34	,	,	PUNCT
dti-1349	20	35	among	among	ADP
dti-1349	20	36	others.2,10,11	others.2,10,11	NOUN
dti-1349	20	37	less	less	ADV
dti-1349	20	38	permeable	permeable	ADJ
dti-1349	20	39	drugs	drug	NOUN
dti-1349	20	40	(	(	PUNCT
dti-1349	20	41	weak	weak	ADJ
dti-1349	20	42	substrates	substrate	NOUN
dti-1349	20	43	)	)	PUNCT
dti-1349	20	44	may	may	AUX
dti-1349	20	45	also	also	ADV
dti-1349	20	46	undergo	undergo	VERB
dti-1349	20	47	a	a	DET
dti-1349	20	48	substantial	substantial	ADJ
dti-1349	20	49	extrusion	extrusion	NOUN
dti-1349	20	50	.	.	PUNCT
dti-1349	21	1	thus	thus	ADV
dti-1349	21	2	it	it	PRON
dti-1349	21	3	contributes	contribute	VERB
dti-1349	21	4	greatly	greatly	ADV
dti-1349	21	5	in	in	ADP
dti-1349	21	6	the	the	DET
dti-1349	21	7	extrusion	extrusion	NOUN
dti-1349	21	8	of	of	ADP
dti-1349	21	9	many	many	ADJ
dti-1349	21	10	drugs	drug	NOUN
dti-1349	21	11	from	from	ADP
dti-1349	21	12	the	the	DET
dti-1349	21	13	blood	blood	NOUN
dti-1349	21	14	into	into	ADP
dti-1349	21	15	the	the	DET
dti-1349	21	16	intestinal	intestinal	ADJ
dti-1349	21	17	lumen	luman	NOUN
dti-1349	21	18	.	.	PUNCT
dti-1349	22	1	p	p	X
dti-1349	22	2	-	-	PUNCT
dti-1349	22	3	gp	gp	NOUN
dti-1349	22	4	is	be	AUX
dti-1349	22	5	also	also	ADV
dti-1349	22	6	responsible	responsible	ADJ
dti-1349	22	7	for	for	ADP
dti-1349	22	8	enhancing	enhance	VERB
dti-1349	22	9	the	the	DET
dti-1349	22	10	excretion	excretion	NOUN
dti-1349	22	11	of	of	ADP
dti-1349	22	12	drugs	drug	NOUN
dti-1349	22	13	out	out	ADP
dti-1349	22	14	of	of	ADP
dti-1349	22	15	hepatocytes	hepatocyte	NOUN
dti-1349	22	16	and	and	CCONJ
dti-1349	22	17	renal	renal	ADJ
dti-1349	22	18	tubules	tubule	NOUN
dti-1349	22	19	into	into	ADP
dti-1349	22	20	the	the	DET
dti-1349	22	21	adjacent	adjacent	ADJ
dti-1349	22	22	luminal	luminal	ADJ
dti-1349	22	23	space	space	NOUN
dti-1349	22	24	.	.	PUNCT
dti-1349	23	1	therefore	therefore	ADV
dti-1349	23	2	,	,	PUNCT
dti-1349	23	3	p	p	X
dti-1349	23	4	-	-	PUNCT
dti-1349	23	5	gp	gp	NOUN
dti-1349	23	6	can	can	AUX
dti-1349	23	7	potentially	potentially	ADV
dti-1349	23	8	reduce	reduce	VERB
dti-1349	23	9	the	the	DET
dti-1349	23	10	absorption	absorption	NOUN
dti-1349	23	11	and	and	CCONJ
dti-1349	23	12	oral	oral	ADJ
dti-1349	23	13	bioavailability	bioavailability	NOUN
dti-1349	23	14	and	and	CCONJ
dti-1349	23	15	decrease	decrease	VERB
dti-1349	23	16	the	the	DET
dti-1349	23	17	retention	retention	NOUN
dti-1349	23	18	time	time	NOUN
dti-1349	23	19	of	of	ADP
dti-1349	23	20	a	a	DET
dti-1349	23	21	number	number	NOUN
dti-1349	23	22	of	of	ADP
dti-1349	23	23	drugs.9,10	drugs.9,10	NOUN
dti-1349	23	24	additionally	additionally	ADV
dti-1349	23	25	,	,	PUNCT
dti-1349	23	26	it	it	PRON
dti-1349	23	27	has	have	VERB
dti-1349	23	28	a	a	DET
dti-1349	23	29	role	role	NOUN
dti-1349	23	30	in	in	ADP
dti-1349	23	31	limiting	limit	VERB
dti-1349	23	32	cellular	cellular	ADJ
dti-1349	23	33	uptake	uptake	NOUN
dti-1349	23	34	of	of	ADP
dti-1349	23	35	drugs	drug	NOUN
dti-1349	23	36	from	from	ADP
dti-1349	23	37	blood	blood	NOUN
dti-1349	23	38	circulation	circulation	NOUN
dti-1349	23	39	into	into	ADP
dti-1349	23	40	the	the	DET
dti-1349	23	41	brain	brain	NOUN
dti-1349	23	42	while	while	SCONJ
dti-1349	23	43	being	be	AUX
dti-1349	23	44	present	present	ADJ
dti-1349	23	45	in	in	ADP
dti-1349	23	46	the	the	DET
dti-1349	23	47	bbb.6	bbb.6	PROPN
dti-1349	23	48	p	p	NOUN
dti-1349	23	49	-	-	PUNCT
dti-1349	23	50	gp	gp	NOUN
dti-1349	23	51	is	be	AUX
dti-1349	23	52	overexpressed	overexpresse	VERB
dti-1349	23	53	in	in	ADP
dti-1349	23	54	cancer	cancer	NOUN
dti-1349	23	55	cells	cell	NOUN
dti-1349	23	56	and	and	CCONJ
dti-1349	23	57	is	be	AUX
dti-1349	23	58	responsible	responsible	ADJ
dti-1349	23	59	for	for	ADP
dti-1349	23	60	drug	drug	NOUN
dti-1349	23	61	efflux	efflux	NOUN
dti-1349	23	62	in	in	ADP
dti-1349	23	63	tumors	tumor	NOUN
dti-1349	23	64	.	.	PUNCT
dti-1349	24	1	it	it	PRON
dti-1349	24	2	prevents	prevent	VERB
dti-1349	24	3	cell	cell	NOUN
dti-1349	24	4	internalization	internalization	NOUN
dti-1349	24	5	of	of	ADP
dti-1349	24	6	chemotherapeutic	chemotherapeutic	ADJ
dti-1349	24	7	agents	agent	NOUN
dti-1349	24	8	and	and	CCONJ
dti-1349	24	9	makes	make	VERB
dti-1349	24	10	the	the	DET
dti-1349	24	11	chemotherapy	chemotherapy	NOUN
dti-1349	24	12	almost	almost	ADV
dti-1349	24	13	ineffective	ineffective	ADJ
dti-1349	24	14	in	in	ADP
dti-1349	24	15	many	many	ADJ
dti-1349	24	16	cases	case	NOUN
dti-1349	24	17	(	(	PUNCT
dti-1349	24	18	fig	fig	NOUN
dti-1349	24	19	.	.	PUNCT
dti-1349	24	20	1	1	NUM
dti-1349	24	21	)	)	PUNCT
dti-1349	24	22	.	.	PUNCT
dti-1349	25	1	hence	hence	ADV
dti-1349	25	2	,	,	PUNCT
dti-1349	25	3	this	this	DET
dti-1349	25	4	protein	protein	NOUN
dti-1349	25	5	is	be	AUX
dti-1349	25	6	one	one	NUM
dti-1349	25	7	of	of	ADP
dti-1349	25	8	the	the	DET
dti-1349	25	9	main	main	ADJ
dti-1349	25	10	barriers	barrier	NOUN
dti-1349	25	11	in	in	ADP
dti-1349	25	12	cancer	cancer	NOUN
dti-1349	25	13	treatment	treatment	NOUN
dti-1349	25	14	by	by	ADP
dti-1349	25	15	chemotherapy.12,13	chemotherapy.12,13	NOUN
dti-1349	25	16	a	a	DET
dti-1349	25	17	variety	variety	NOUN
dti-1349	25	18	of	of	ADP
dti-1349	25	19	strategies	strategy	NOUN
dti-1349	25	20	are	be	AUX
dti-1349	25	21	being	be	AUX
dti-1349	25	22	developed	develop	VERB
dti-1349	25	23	to	to	PART
dti-1349	25	24	overcome	overcome	VERB
dti-1349	25	25	the	the	DET
dti-1349	25	26	difficulties	difficulty	NOUN
dti-1349	25	27	associated	associate	VERB
dti-1349	25	28	with	with	ADP
dti-1349	25	29	p	p	NOUN
dti-1349	25	30	-	-	PUNCT
dti-1349	25	31	gp	gp	NOUN
dti-1349	25	32	in	in	ADP
dti-1349	25	33	optimum	optimum	ADJ
dti-1349	25	34	drug	drug	NOUN
dti-1349	25	35	delivery	delivery	NOUN
dti-1349	25	36	.	.	PUNCT
dti-1349	26	1	those	those	PRON
dti-1349	26	2	include	include	VERB
dti-1349	26	3	not	not	PART
dti-1349	26	4	only	only	ADV
dti-1349	26	5	inhibition	inhibition	NOUN
dti-1349	26	6	of	of	ADP
dti-1349	26	7	p	p	NOUN
dti-1349	26	8	-	-	PUNCT
dti-1349	26	9	gp	gp	NOUN
dti-1349	26	10	,	,	PUNCT
dti-1349	26	11	but	but	CCONJ
dti-1349	26	12	also	also	ADV
dti-1349	26	13	various	various	ADJ
dti-1349	26	14	techniques	technique	NOUN
dti-1349	26	15	to	to	PART
dti-1349	26	16	bypass	bypass	VERB
dti-1349	26	17	it.1,4,15,16	it.1,4,15,16	NOUN
dti-1349	26	18	these	these	DET
dti-1349	26	19	promising	promising	ADJ
dti-1349	26	20	approaches	approach	NOUN
dti-1349	26	21	for	for	ADP
dti-1349	26	22	optimizing	optimize	VERB
dti-1349	26	23	drug	drug	NOUN
dti-1349	26	24	delivery	delivery	NOUN
dti-1349	26	25	and	and	CCONJ
dti-1349	26	26	targeting	targeting	NOUN
dti-1349	26	27	will	will	AUX
dti-1349	26	28	be	be	AUX
dti-1349	26	29	the	the	DET
dti-1349	26	30	focus	focus	NOUN
dti-1349	26	31	of	of	ADP
dti-1349	26	32	discussions	discussion	NOUN
dti-1349	26	33	in	in	ADP
dti-1349	26	34	this	this	DET
dti-1349	26	35	review	review	NOUN
dti-1349	26	36	.	.	PUNCT
dti-1349	27	1	inhibition	inhibition	NOUN
dti-1349	27	2	of	of	ADP
dti-1349	27	3	p	p	NOUN
dti-1349	27	4	-	-	PUNCT
dti-1349	27	5	gp	gp	NOUN
dti-1349	27	6	the	the	DET
dti-1349	27	7	inhibition	inhibition	NOUN
dti-1349	27	8	of	of	ADP
dti-1349	27	9	efflux	efflux	NOUN
dti-1349	27	10	pump	pump	NOUN
dti-1349	27	11	is	be	AUX
dti-1349	27	12	mainly	mainly	ADV
dti-1349	27	13	done	do	VERB
dti-1349	27	14	in	in	ADP
dti-1349	27	15	order	order	NOUN
dti-1349	27	16	to	to	PART
dti-1349	27	17	improve	improve	VERB
dti-1349	27	18	the	the	DET
dti-1349	27	19	delivery	delivery	NOUN
dti-1349	27	20	of	of	ADP
dti-1349	27	21	therapeutic	therapeutic	ADJ
dti-1349	27	22	agents	agent	NOUN
dti-1349	27	23	.	.	PUNCT
dti-1349	28	1	in	in	ADP
dti-1349	28	2	general	general	ADJ
dti-1349	28	3	,	,	PUNCT
dti-1349	28	4	p	p	NOUN
dti-1349	28	5	-	-	PUNCT
dti-1349	28	6	gp	gp	NOUN
dti-1349	28	7	can	can	AUX
dti-1349	28	8	be	be	AUX
dti-1349	28	9	inhibited	inhibit	VERB
dti-1349	28	10	by	by	ADP
dti-1349	28	11	three	three	NUM
dti-1349	28	12	mechanisms	mechanism	NOUN
dti-1349	28	13	:	:	PUNCT
dti-1349	28	14	(	(	PUNCT
dti-1349	28	15	i	i	NOUN
dti-1349	28	16	)	)	PUNCT
dti-1349	28	17	blocking	block	VERB
dti-1349	28	18	drug	drug	NOUN
dti-1349	28	19	binding	bind	VERB
dti-1349	28	20	site	site	NOUN
dti-1349	28	21	either	either	CCONJ
dti-1349	28	22	competitively	competitively	ADV
dti-1349	28	23	,	,	PUNCT
dti-1349	28	24	non	non	ADJ
dti-1349	28	25	-	-	ADJ
dti-1349	28	26	competitively	competitively	ADV
dti-1349	28	27	(	(	PUNCT
dti-1349	28	28	fig	fig	NOUN
dti-1349	28	29	.	.	NOUN
dti-1349	29	1	2	2	NUM
dti-1349	29	2	)	)	PUNCT
dti-1349	29	3	or	or	CCONJ
dti-1349	29	4	allosterically	allosterically	ADV
dti-1349	29	5	;	;	PUNCT
dti-1349	29	6	(	(	PUNCT
dti-1349	29	7	ii	ii	NOUN
dti-1349	29	8	)	)	PUNCT
dti-1349	29	9	interfering	interfere	VERB
dti-1349	29	10	with	with	ADP
dti-1349	29	11	atp	atp	NOUN
dti-1349	29	12	hydrolysis	hydrolysis	NOUN
dti-1349	29	13	;	;	PUNCT
dti-1349	29	14	and	and	CCONJ
dti-1349	29	15	(	(	PUNCT
dti-1349	29	16	iii	iii	NOUN
dti-1349	29	17	)	)	PUNCT
dti-1349	29	18	altering	alter	VERB
dti-1349	29	19	integrity	integrity	NOUN
dti-1349	29	20	of	of	ADP
dti-1349	29	21	cell	cell	NOUN
dti-1349	29	22	membrane	membrane	NOUN
dti-1349	29	23	lipids.1,10,17–19	lipids.1,10,17–19	PROPN
dti-1349	29	24	the	the	DET
dti-1349	29	25	goal	goal	NOUN
dti-1349	29	26	is	be	AUX
dti-1349	29	27	to	to	PART
dti-1349	29	28	achieve	achieve	VERB
dti-1349	29	29	improved	improved	ADJ
dti-1349	29	30	drug	drug	NOUN
dti-1349	29	31	bioavailability	bioavailability	NOUN
dti-1349	29	32	,	,	PUNCT
dti-1349	29	33	uptake	uptake	NOUN
dti-1349	29	34	of	of	ADP
dti-1349	29	35	drug	drug	NOUN
dti-1349	29	36	in	in	ADP
dti-1349	29	37	the	the	DET
dti-1349	29	38	targeted	target	VERB
dti-1349	29	39	organ	organ	NOUN
dti-1349	29	40	,	,	PUNCT
dti-1349	29	41	and	and	CCONJ
dti-1349	29	42	more	more	ADV
dti-1349	29	43	efficacious	efficacious	ADJ
dti-1349	29	44	cancer	cancer	NOUN
dti-1349	29	45	chemotherapy	chemotherapy	NOUN
dti-1349	29	46	through	through	ADP
dti-1349	29	47	the	the	DET
dti-1349	29	48	ability	ability	NOUN
dti-1349	29	49	to	to	PART
dti-1349	29	50	selectively	selectively	ADV
dti-1349	29	51	block	block	VERB
dti-1349	29	52	the	the	DET
dti-1349	29	53	action	action	NOUN
dti-1349	29	54	of	of	ADP
dti-1349	29	55	p	p	NOUN
dti-1349	29	56	-	-	PUNCT
dti-1349	29	57	gp	gp	NOUN
dti-1349	29	58	.	.	PUNCT
dti-1349	30	1	inhibitors	inhibitor	NOUN
dti-1349	30	2	are	be	AUX
dti-1349	30	3	as	as	ADV
dti-1349	30	4	structurally	structurally	ADV
dti-1349	30	5	diverse	diverse	ADJ
dti-1349	30	6	as	as	SCONJ
dti-1349	30	7	substrates.19	substrates.19	NOUN
dti-1349	30	8	many	many	ADJ
dti-1349	30	9	inhibitors	inhibitor	NOUN
dti-1349	30	10	figure	figure	VERB
dti-1349	30	11	1	1	NUM
dti-1349	30	12	.	.	PUNCT
dti-1349	30	13	drug	drug	NOUN
dti-1349	30	14	efflux	efflux	VERB
dti-1349	30	15	by	by	ADP
dti-1349	30	16	p	p	NOUN
dti-1349	30	17	-	-	PUNCT
dti-1349	30	18	glycoprotein	glycoprotein	NOUN
dti-1349	30	19	.	.	PUNCT
dti-1349	31	1	http://www.la-press.com	http://www.la-press.com	X
dti-1349	32	1	p	p	X
dti-1349	32	2	-	-	PUNCT
dti-1349	32	3	glycoprotein	glycoprotein	NOUN
dti-1349	32	4	inhibition	inhibition	NOUN
dti-1349	32	5	for	for	ADP
dti-1349	32	6	optimal	optimal	ADJ
dti-1349	32	7	drug	drug	NOUN
dti-1349	32	8	delivery	delivery	NOUN
dti-1349	32	9	drug	drug	NOUN
dti-1349	32	10	target	target	NOUN
dti-1349	32	11	insights	insight	NOUN
dti-1349	32	12	2013:7	2013:7	NUM
dti-1349	32	13	29	29	NUM
dti-1349	32	14	(	(	PUNCT
dti-1349	32	15	verapamil	verapamil	NOUN
dti-1349	32	16	,	,	PUNCT
dti-1349	32	17	cyclosporin	cyclosporin	NOUN
dti-1349	32	18	a	a	NOUN
dti-1349	32	19	,	,	PUNCT
dti-1349	32	20	trans	trans	NOUN
dti-1349	32	21	-	-	NOUN
dti-1349	32	22	flupenthixol	flupenthixol	NOUN
dti-1349	32	23	,	,	PUNCT
dti-1349	32	24	etc	etc	X
dti-1349	32	25	.	.	X
dti-1349	32	26	)	)	PUNCT
dti-1349	32	27	are	be	AUX
dti-1349	32	28	themselves	themselves	PRON
dti-1349	32	29	transported	transport	VERB
dti-1349	32	30	by	by	ADP
dti-1349	32	31	p	p	NOUN
dti-1349	32	32	-	-	PUNCT
dti-1349	32	33	gp.2	gp.2	NOUN
dti-1349	32	34	p	p	NOUN
dti-1349	32	35	-	-	PUNCT
dti-1349	32	36	gp	gp	NOUN
dti-1349	32	37	inhibitors	inhibitor	NOUN
dti-1349	32	38	are	be	AUX
dti-1349	32	39	classified	classify	VERB
dti-1349	32	40	into	into	ADP
dti-1349	32	41	three	three	NUM
dti-1349	32	42	generations	generation	NOUN
dti-1349	32	43	based	base	VERB
dti-1349	32	44	on	on	ADP
dti-1349	32	45	their	their	PRON
dti-1349	32	46	specificity	specificity	NOUN
dti-1349	32	47	,	,	PUNCT
dti-1349	32	48	affinity	affinity	NOUN
dti-1349	32	49	,	,	PUNCT
dti-1349	32	50	and	and	CCONJ
dti-1349	32	51	toxicity	toxicity	NOUN
dti-1349	32	52	.	.	PUNCT
dti-1349	33	1	first	first	ADJ
dti-1349	33	2	generation	generation	NOUN
dti-1349	33	3	inhibitors	inhibitor	NOUN
dti-1349	33	4	are	be	AUX
dti-1349	33	5	pharmacologically	pharmacologically	ADV
dti-1349	33	6	active	active	ADJ
dti-1349	33	7	substances	substance	NOUN
dti-1349	33	8	which	which	PRON
dti-1349	33	9	are	be	AUX
dti-1349	33	10	clinically	clinically	ADV
dti-1349	33	11	used	use	VERB
dti-1349	33	12	for	for	ADP
dti-1349	33	13	specific	specific	ADJ
dti-1349	33	14	treatments	treatment	NOUN
dti-1349	33	15	but	but	CCONJ
dti-1349	33	16	have	have	VERB
dti-1349	33	17	the	the	DET
dti-1349	33	18	ability	ability	NOUN
dti-1349	33	19	to	to	PART
dti-1349	33	20	inhibit	inhibit	VERB
dti-1349	33	21	p	p	NOUN
dti-1349	33	22	-	-	PUNCT
dti-1349	33	23	gp	gp	NOUN
dti-1349	33	24	.	.	PUNCT
dti-1349	34	1	the	the	DET
dti-1349	34	2	usage	usage	NOUN
dti-1349	34	3	of	of	ADP
dti-1349	34	4	first	first	ADJ
dti-1349	34	5	generation	generation	NOUN
dti-1349	34	6	inhibitors	inhibitor	NOUN
dti-1349	34	7	is	be	AUX
dti-1349	34	8	limited	limit	VERB
dti-1349	34	9	due	due	ADP
dti-1349	34	10	to	to	ADP
dti-1349	34	11	their	their	PRON
dti-1349	34	12	high	high	ADJ
dti-1349	34	13	serum	serum	NOUN
dti-1349	34	14	concentrations	concentration	NOUN
dti-1349	34	15	(	(	PUNCT
dti-1349	34	16	at	at	ADP
dti-1349	34	17	the	the	DET
dti-1349	34	18	doses	dose	NOUN
dti-1349	34	19	that	that	PRON
dti-1349	34	20	are	be	AUX
dti-1349	34	21	required	require	VERB
dti-1349	34	22	to	to	PART
dti-1349	34	23	inhibit	inhibit	VERB
dti-1349	34	24	p	p	NOUN
dti-1349	34	25	-	-	PUNCT
dti-1349	34	26	gp	gp	NOUN
dti-1349	34	27	)	)	PUNCT
dti-1349	34	28	and	and	CCONJ
dti-1349	34	29	potential	potential	ADJ
dti-1349	34	30	toxicity.20,21	toxicity.20,21	NOUN
dti-1349	34	31	they	they	PRON
dti-1349	34	32	are	be	AUX
dti-1349	34	33	substrate	substrate	NOUN
dti-1349	34	34	to	to	ADP
dti-1349	34	35	other	other	ADJ
dti-1349	34	36	transporters	transporter	NOUN
dti-1349	34	37	and	and	CCONJ
dti-1349	34	38	enzyme	enzyme	NOUN
dti-1349	34	39	systems	system	NOUN
dti-1349	34	40	,	,	PUNCT
dti-1349	34	41	resulting	result	VERB
dti-1349	34	42	in	in	ADP
dti-1349	34	43	unpredictable	unpredictable	ADJ
dti-1349	34	44	pharmacokinetic	pharmacokinetic	ADJ
dti-1349	34	45	interactions	interaction	NOUN
dti-1349	34	46	.	.	PUNCT
dti-1349	35	1	second	second	ADJ
dti-1349	35	2	generation	generation	NOUN
dti-1349	35	3	inhibitors	inhibitor	NOUN
dti-1349	35	4	lack	lack	VERB
dti-1349	35	5	the	the	DET
dti-1349	35	6	pharmacological	pharmacological	ADJ
dti-1349	35	7	activities	activity	NOUN
dti-1349	35	8	and	and	CCONJ
dti-1349	35	9	possess	possess	VERB
dti-1349	35	10	a	a	DET
dti-1349	35	11	greater	great	ADJ
dti-1349	35	12	p	p	NOUN
dti-1349	35	13	-	-	PUNCT
dti-1349	35	14	gp	gp	NOUN
dti-1349	35	15	affinity	affinity	NOUN
dti-1349	35	16	which	which	PRON
dti-1349	35	17	include	include	VERB
dti-1349	35	18	non	non	ADJ
dti-1349	35	19	-	-	ADJ
dti-1349	35	20	immunosuppressive	immunosuppressive	ADJ
dti-1349	35	21	analogues	analogue	NOUN
dti-1349	35	22	of	of	ADP
dti-1349	35	23	cyclosporin	cyclosporin	PROPN
dti-1349	35	24	a	a	PRON
dti-1349	35	25	(	(	PUNCT
dti-1349	35	26	psc833	psc833	PROPN
dti-1349	35	27	)	)	PUNCT
dti-1349	35	28	and	and	CCONJ
dti-1349	35	29	d	d	X
dti-1349	35	30	-	-	PUNCT
dti-1349	35	31	isomer	isomer	ADJ
dti-1349	35	32	of	of	ADP
dti-1349	35	33	verapamil	verapamil	NOUN
dti-1349	35	34	(	(	PUNCT
dti-1349	35	35	dexverapamil	dexverapamil	NOUN
dti-1349	35	36	)	)	PUNCT
dti-1349	35	37	.	.	PUNCT
dti-1349	36	1	however	however	ADV
dti-1349	36	2	,	,	PUNCT
dti-1349	36	3	second	second	ADJ
dti-1349	36	4	generation	generation	NOUN
dti-1349	36	5	inhibitors	inhibitor	NOUN
dti-1349	36	6	inhibit	inhibit	VERB
dti-1349	36	7	the	the	DET
dti-1349	36	8	cypa4	cypa4	NOUN
dti-1349	36	9	enzyme	enzyme	NOUN
dti-1349	36	10	and	and	CCONJ
dti-1349	36	11	other	other	ADJ
dti-1349	36	12	abc	abc	PROPN
dti-1349	36	13	transporters	transporter	NOUN
dti-1349	36	14	.	.	PUNCT
dti-1349	37	1	hence	hence	ADV
dti-1349	37	2	,	,	PUNCT
dti-1349	37	3	metabolizing	metabolize	VERB
dti-1349	37	4	rate	rate	NOUN
dti-1349	37	5	decreases	decrease	NOUN
dti-1349	37	6	and	and	CCONJ
dti-1349	37	7	inhibition	inhibition	NOUN
dti-1349	37	8	of	of	ADP
dti-1349	37	9	two	two	NUM
dti-1349	37	10	or	or	CCONJ
dti-1349	37	11	more	more	ADJ
dti-1349	37	12	abc	abc	PROPN
dti-1349	37	13	transporters	transporter	NOUN
dti-1349	37	14	lead	lead	VERB
dti-1349	37	15	to	to	ADP
dti-1349	37	16	complicated	complicated	ADJ
dti-1349	37	17	pharmacokinetic	pharmacokinetic	ADJ
dti-1349	37	18	alterations	alteration	NOUN
dti-1349	37	19	.	.	PUNCT
dti-1349	38	1	third	third	ADJ
dti-1349	38	2	generation	generation	NOUN
dti-1349	38	3	p	p	NOUN
dti-1349	38	4	-	-	PUNCT
dti-1349	38	5	gp	gp	NOUN
dti-1349	38	6	inhibitors	inhibitor	NOUN
dti-1349	38	7	are	be	AUX
dti-1349	38	8	under	under	ADP
dti-1349	38	9	clinical	clinical	ADJ
dti-1349	38	10	development	development	NOUN
dti-1349	38	11	,	,	PUNCT
dti-1349	38	12	aiming	aim	VERB
dti-1349	38	13	to	to	PART
dti-1349	38	14	inhibit	inhibit	VERB
dti-1349	38	15	p	p	NOUN
dti-1349	38	16	-	-	NOUN
dti-1349	38	17	gp	gp	NOUN
dti-1349	38	18	with	with	ADP
dti-1349	38	19	higher	high	ADJ
dti-1349	38	20	specificity	specificity	NOUN
dti-1349	38	21	and	and	CCONJ
dti-1349	38	22	lower	low	ADJ
dti-1349	38	23	toxicity	toxicity	NOUN
dti-1349	38	24	(	(	PUNCT
dti-1349	38	25	eg	eg	NOUN
dti-1349	38	26	,	,	PUNCT
dti-1349	38	27	tariquidar	tariquidar	NOUN
dti-1349	38	28	)	)	PUNCT
dti-1349	38	29	.	.	PUNCT
dti-1349	39	1	they	they	PRON
dti-1349	39	2	are	be	AUX
dti-1349	39	3	developed	develop	VERB
dti-1349	39	4	by	by	ADP
dti-1349	39	5	using	use	VERB
dti-1349	39	6	structure	structure	NOUN
dti-1349	39	7	activity	activity	NOUN
dti-1349	39	8	relationships	relationship	NOUN
dti-1349	39	9	and	and	CCONJ
dti-1349	39	10	many	many	ADJ
dti-1349	39	11	were	be	AUX
dti-1349	39	12	found	find	VERB
dti-1349	39	13	to	to	PART
dti-1349	39	14	be	be	AUX
dti-1349	39	15	very	very	ADV
dti-1349	39	16	specific	specific	ADJ
dti-1349	39	17	and	and	CCONJ
dti-1349	39	18	effective	effective	ADJ
dti-1349	39	19	against	against	ADP
dti-1349	39	20	p	p	NOUN
dti-1349	39	21	-	-	PUNCT
dti-1349	39	22	gp	gp	NOUN
dti-1349	39	23	,	,	PUNCT
dti-1349	39	24	having	have	VERB
dti-1349	39	25	minimal	minimal	ADJ
dti-1349	39	26	toxicity.22–24	toxicity.22–24	NOUN
dti-1349	39	27	table	table	NOUN
dti-1349	39	28	1	1	NUM
dti-1349	39	29	illustrates	illustrate	VERB
dti-1349	39	30	the	the	DET
dti-1349	39	31	detailed	detailed	ADJ
dti-1349	39	32	classification	classification	NOUN
dti-1349	39	33	of	of	ADP
dti-1349	39	34	p	p	NOUN
dti-1349	39	35	-	-	PUNCT
dti-1349	39	36	gp	gp	NOUN
dti-1349	39	37	inhibitors	inhibitor	NOUN
dti-1349	39	38	.	.	PUNCT
dti-1349	40	1	figure	figure	NOUN
dti-1349	40	2	2	2	NUM
dti-1349	40	3	.	.	PUNCT
dti-1349	40	4	inhibition	inhibition	NOUN
dti-1349	40	5	of	of	ADP
dti-1349	40	6	p	p	NOUN
dti-1349	40	7	-	-	PUNCT
dti-1349	40	8	glycoprotein	glycoprotein	NOUN
dti-1349	40	9	to	to	PART
dti-1349	40	10	prevent	prevent	VERB
dti-1349	40	11	drug	drug	NOUN
dti-1349	40	12	efflux	efflux	NOUN
dti-1349	40	13	.	.	PUNCT
dti-1349	41	1	table	table	NOUN
dti-1349	41	2	1	1	NUM
dti-1349	41	3	.	.	PUNCT
dti-1349	42	1	classification	classification	NOUN
dti-1349	42	2	of	of	ADP
dti-1349	42	3	p	p	NOUN
dti-1349	42	4	-	-	PUNCT
dti-1349	42	5	gp	gp	NOUN
dti-1349	42	6	inhibitors.1,20,23,25–27	inhibitors.1,20,23,25–27	NOUN
dti-1349	42	7	generations	generation	NOUN
dti-1349	42	8	examples	example	NOUN
dti-1349	42	9	specificity	specificity	NOUN
dti-1349	42	10	limitations	limitation	VERB
dti-1349	42	11	first	first	ADJ
dti-1349	42	12	generation	generation	NOUN
dti-1349	42	13	verapamil	verapamil	NOUN
dti-1349	42	14	,	,	PUNCT
dti-1349	42	15	cyclosporin	cyclosporin	NOUN
dti-1349	42	16	a	a	NOUN
dti-1349	42	17	,	,	PUNCT
dti-1349	42	18	reserpine	reserpine	NOUN
dti-1349	42	19	,	,	PUNCT
dti-1349	42	20	quinidine	quinidine	ADJ
dti-1349	42	21	,	,	PUNCT
dti-1349	42	22	yohimbine	yohimbine	NOUN
dti-1349	42	23	,	,	PUNCT
dti-1349	42	24	tamoxifen	tamoxifen	NOUN
dti-1349	42	25	and	and	CCONJ
dti-1349	42	26	toremifena	toremifena	ADJ
dti-1349	42	27	non	non	ADJ
dti-1349	42	28	-	-	ADJ
dti-1349	42	29	selective	selective	ADJ
dti-1349	42	30	and	and	CCONJ
dti-1349	42	31	low	low	ADJ
dti-1349	42	32	binding	bind	VERB
dti-1349	42	33	affinities	affinity	NOUN
dti-1349	42	34	.	.	PUNCT
dti-1349	43	1	they	they	PRON
dti-1349	43	2	are	be	AUX
dti-1349	43	3	substrates	substrate	NOUN
dti-1349	43	4	to	to	ADP
dti-1349	43	5	other	other	ADJ
dti-1349	43	6	transporters	transporter	NOUN
dti-1349	43	7	and	and	CCONJ
dti-1349	43	8	enzyme	enzyme	NOUN
dti-1349	43	9	systems	system	NOUN
dti-1349	43	10	.	.	PUNCT
dti-1349	44	1	they	they	PRON
dti-1349	44	2	are	be	AUX
dti-1349	44	3	pharmacologically	pharmacologically	ADV
dti-1349	44	4	active	active	ADJ
dti-1349	44	5	.	.	PUNCT
dti-1349	45	1	they	they	PRON
dti-1349	45	2	themselves	themselves	PRON
dti-1349	45	3	are	be	AUX
dti-1349	45	4	transported	transport	VERB
dti-1349	45	5	by	by	ADP
dti-1349	45	6	p	p	NOUN
dti-1349	45	7	-	-	PUNCT
dti-1349	45	8	gp	gp	NOUN
dti-1349	45	9	.	.	PUNCT
dti-1349	46	1	second	second	ADJ
dti-1349	46	2	generation	generation	NOUN
dti-1349	46	3	dexverapamil	dexverapamil	NOUN
dti-1349	46	4	,	,	PUNCT
dti-1349	46	5	dexniguldipine	dexniguldipine	PROPN
dti-1349	46	6	,	,	PUNCT
dti-1349	46	7	valspodar	valspodar	PROPN
dti-1349	46	8	(	(	PUNCT
dti-1349	46	9	psc	psc	PROPN
dti-1349	46	10	833	833	NUM
dti-1349	46	11	)	)	PUNCT
dti-1349	46	12	,	,	PUNCT
dti-1349	46	13	and	and	CCONJ
dti-1349	46	14	dofequidar	dofequidar	NOUN
dti-1349	46	15	fumarate	fumarate	NOUN
dti-1349	46	16	(	(	PUNCT
dti-1349	46	17	ms-209	ms-209	NOUN
dti-1349	46	18	)	)	PUNCT
dti-1349	46	19	higher	high	ADJ
dti-1349	46	20	specificity	specificity	NOUN
dti-1349	46	21	then	then	ADV
dti-1349	46	22	first	first	ADJ
dti-1349	46	23	generation	generation	NOUN
dti-1349	46	24	inhibitors	inhibitor	NOUN
dti-1349	46	25	but	but	CCONJ
dti-1349	46	26	interact	interact	VERB
dti-1349	46	27	with	with	ADP
dti-1349	46	28	other	other	ADJ
dti-1349	46	29	systems	system	NOUN
dti-1349	46	30	.	.	PUNCT
dti-1349	47	1	they	they	PRON
dti-1349	47	2	are	be	AUX
dti-1349	47	3	substrates	substrate	NOUN
dti-1349	47	4	to	to	ADP
dti-1349	47	5	cyp	cyp	VERB
dti-1349	47	6	3a4	3a4	NUM
dti-1349	47	7	enzyme	enzyme	NOUN
dti-1349	47	8	and	and	CCONJ
dti-1349	47	9	other	other	ADJ
dti-1349	47	10	abc	abc	PROPN
dti-1349	47	11	transporters	transporter	NOUN
dti-1349	47	12	.	.	PUNCT
dti-1349	48	1	third	third	ADJ
dti-1349	48	2	generation	generation	NOUN
dti-1349	48	3	cyclopropyldibenzosuberane	cyclopropyldibenzosuberane	PROPN
dti-1349	48	4	zosuquidar	zosuquidar	NOUN
dti-1349	48	5	(	(	PUNCT
dti-1349	48	6	ly335979	ly335979	PROPN
dti-1349	48	7	)	)	PUNCT
dti-1349	48	8	,	,	PUNCT
dti-1349	48	9	laniquidar	laniquidar	NOUN
dti-1349	48	10	(	(	PUNCT
dti-1349	48	11	r101933	r101933	NOUN
dti-1349	48	12	)	)	PUNCT
dti-1349	48	13	,	,	PUNCT
dti-1349	48	14	mitotane	mitotane	NOUN
dti-1349	48	15	(	(	PUNCT
dti-1349	48	16	nsc-38721	nsc-38721	NOUN
dti-1349	48	17	)	)	PUNCT
dti-1349	48	18	,	,	PUNCT
dti-1349	48	19	biricodar	biricodar	PROPN
dti-1349	48	20	(	(	PUNCT
dti-1349	48	21	vx-710	vx-710	PROPN
dti-1349	48	22	)	)	PUNCT
dti-1349	48	23	,	,	PUNCT
dti-1349	48	24	elacridar	elacridar	PROPN
dti-1349	48	25	(	(	PUNCT
dti-1349	48	26	gf120918	gf120918	PROPN
dti-1349	48	27	/	/	SYM
dti-1349	48	28	gg918	gg918	PROPN
dti-1349	48	29	)	)	PUNCT
dti-1349	48	30	,	,	PUNCT
dti-1349	48	31	ont-093	ont-093	PROPN
dti-1349	48	32	,	,	PUNCT
dti-1349	48	33	tariquidar	tariquidar	PROPN
dti-1349	48	34	(	(	PUNCT
dti-1349	48	35	xr9576	xr9576	PROPN
dti-1349	48	36	)	)	PUNCT
dti-1349	48	37	,	,	PUNCT
dti-1349	48	38	and	and	CCONJ
dti-1349	48	39	hm30181	hm30181	ADJ
dti-1349	48	40	highest	high	ADJ
dti-1349	48	41	specificity	specificity	NOUN
dti-1349	48	42	that	that	PRON
dti-1349	48	43	specifically	specifically	ADV
dti-1349	48	44	and	and	CCONJ
dti-1349	48	45	potently	potently	ADV
dti-1349	48	46	inhibit	inhibit	VERB
dti-1349	48	47	p	p	NOUN
dti-1349	48	48	-	-	PUNCT
dti-1349	48	49	gp	gp	NOUN
dti-1349	48	50	function	function	NOUN
dti-1349	48	51	.	.	PUNCT
dti-1349	49	1	no	no	DET
dti-1349	49	2	limitations	limitation	NOUN
dti-1349	49	3	like	like	ADP
dti-1349	49	4	the	the	DET
dti-1349	49	5	first	first	ADJ
dti-1349	49	6	and	and	CCONJ
dti-1349	49	7	the	the	DET
dti-1349	49	8	second	second	ADJ
dti-1349	49	9	generation	generation	NOUN
dti-1349	49	10	inhibitors	inhibitor	NOUN
dti-1349	49	11	.	.	PUNCT
dti-1349	50	1	http://www.la-press.com	http://www.la-press.com	X
dti-1349	50	2	amin	amin	PROPN
dti-1349	50	3	30	30	NUM
dti-1349	50	4	drug	drug	NOUN
dti-1349	50	5	target	target	NOUN
dti-1349	50	6	insights	insight	NOUN
dti-1349	50	7	2013:7	2013:7	NUM
dti-1349	50	8	monoclonal	monoclonal	NOUN
dti-1349	50	9	antibodies	antibody	NOUN
dti-1349	50	10	can	can	AUX
dti-1349	50	11	be	be	AUX
dti-1349	50	12	effectively	effectively	ADV
dti-1349	50	13	used	use	VERB
dti-1349	50	14	against	against	ADP
dti-1349	50	15	p	p	NOUN
dti-1349	50	16	-	-	PUNCT
dti-1349	50	17	gp	gp	NOUN
dti-1349	50	18	in	in	ADP
dti-1349	50	19	multidrug	multidrug	NOUN
dti-1349	50	20	resistance	resistance	NOUN
dti-1349	50	21	(	(	PUNCT
dti-1349	50	22	mdr	mdr	NOUN
dti-1349	50	23	)	)	PUNCT
dti-1349	50	24	tumor	tumor	NOUN
dti-1349	50	25	cells	cell	NOUN
dti-1349	50	26	.	.	PUNCT
dti-1349	51	1	many	many	ADJ
dti-1349	51	2	anti	anti	ADJ
dti-1349	51	3	-	-	ADJ
dti-1349	51	4	p	p	ADJ
dti-1349	51	5	-	-	PUNCT
dti-1349	51	6	gp	gp	NOUN
dti-1349	51	7	monoclonal	monoclonal	NOUN
dti-1349	51	8	antibodies	antibodie	VERB
dti-1349	51	9	,	,	PUNCT
dti-1349	51	10	such	such	ADJ
dti-1349	51	11	as	as	ADP
dti-1349	51	12	mrk16	mrk16	NOUN
dti-1349	51	13	and	and	CCONJ
dti-1349	51	14	mrk17	mrk17	ADJ
dti-1349	51	15	,	,	PUNCT
dti-1349	51	16	have	have	AUX
dti-1349	51	17	been	be	AUX
dti-1349	51	18	developed	develop	VERB
dti-1349	51	19	to	to	PART
dti-1349	51	20	overcome	overcome	VERB
dti-1349	51	21	multidrug	multidrug	NOUN
dti-1349	51	22	resistance	resistance	NOUN
dti-1349	51	23	.	.	PUNCT
dti-1349	52	1	conjugated	conjugate	VERB
dti-1349	52	2	monoclonal	monoclonal	NOUN
dti-1349	52	3	antibodies	antibodie	VERB
dti-1349	52	4	,	,	PUNCT
dti-1349	52	5	such	such	ADJ
dti-1349	52	6	as	as	ADP
dti-1349	52	7	bispecific	bispecific	NOUN
dti-1349	52	8	antibody	antibody	NOUN
dti-1349	52	9	,	,	PUNCT
dti-1349	52	10	immunotoxin	immunotoxin	NOUN
dti-1349	52	11	,	,	PUNCT
dti-1349	52	12	and	and	CCONJ
dti-1349	52	13	radioisotope	radioisotope	NOUN
dti-1349	52	14	conjugates	conjugate	NOUN
dti-1349	52	15	,	,	PUNCT
dti-1349	52	16	have	have	AUX
dti-1349	52	17	also	also	ADV
dti-1349	52	18	been	be	AUX
dti-1349	52	19	constructed	construct	VERB
dti-1349	52	20	to	to	PART
dti-1349	52	21	enhance	enhance	VERB
dti-1349	52	22	the	the	DET
dti-1349	52	23	anti	anti	ADJ
dti-1349	52	24	-	-	ADJ
dti-1349	52	25	tumor	tumor	ADJ
dti-1349	52	26	activity	activity	NOUN
dti-1349	52	27	of	of	ADP
dti-1349	52	28	monoclonal	monoclonal	NOUN
dti-1349	52	29	antibodies.28	antibodies.28	NOUN
dti-1349	52	30	the	the	DET
dti-1349	52	31	conformation	conformation	NOUN
dti-1349	52	32	-	-	PUNCT
dti-1349	52	33	sensitive	sensitive	ADJ
dti-1349	52	34	uic2	uic2	ADJ
dti-1349	52	35	monoclonal	monoclonal	NOUN
dti-1349	52	36	antibody	antibody	NOUN
dti-1349	52	37	can	can	AUX
dti-1349	52	38	inhibit	inhibit	VERB
dti-1349	52	39	p	p	NOUN
dti-1349	52	40	-	-	PUNCT
dti-1349	52	41	gp	gp	NOUN
dti-1349	52	42	mediated	mediate	VERB
dti-1349	52	43	substrate	substrate	NOUN
dti-1349	52	44	transport	transport	NOUN
dti-1349	52	45	(	(	PUNCT
dti-1349	52	46	calcein	calcein	NOUN
dti-1349	52	47	-	-	PUNCT
dti-1349	52	48	am	am	NOUN
dti-1349	52	49	,	,	PUNCT
dti-1349	52	50	daunorubicin	daunorubicin	PROPN
dti-1349	52	51	,	,	PUNCT
dti-1349	52	52	and	and	CCONJ
dti-1349	52	53	99	99	NUM
dti-1349	52	54	mtc	mtc	NOUN
dti-1349	52	55	-	-	PUNCT
dti-1349	52	56	hexakis-2	hexakis-2	NUM
dti-1349	52	57	-	-	PUNCT
dti-1349	52	58	methoxybutylisonitrile	methoxybutylisonitrile	NOUN
dti-1349	52	59	)	)	PUNCT
dti-1349	52	60	.	.	PUNCT
dti-1349	53	1	however	however	ADV
dti-1349	53	2	,	,	PUNCT
dti-1349	53	3	inhibition	inhibition	NOUN
dti-1349	53	4	by	by	ADP
dti-1349	53	5	uic2	uic2	PROPN
dti-1349	53	6	alone	alone	ADV
dti-1349	53	7	is	be	AUX
dti-1349	53	8	usually	usually	ADV
dti-1349	53	9	partial	partial	ADJ
dti-1349	53	10	because	because	SCONJ
dti-1349	53	11	uic2	uic2	PROPN
dti-1349	53	12	binds	bind	VERB
dti-1349	53	13	only	only	ADV
dti-1349	53	14	10	10	NUM
dti-1349	53	15	%	%	NOUN
dti-1349	53	16	to	to	PART
dti-1349	53	17	40	40	NUM
dti-1349	53	18	%	%	NOUN
dti-1349	53	19	of	of	ADP
dti-1349	53	20	p	p	NOUN
dti-1349	53	21	-	-	PUNCT
dti-1349	53	22	gp	gp	NOUN
dti-1349	53	23	present	present	NOUN
dti-1349	53	24	in	in	ADP
dti-1349	53	25	the	the	DET
dti-1349	53	26	cell	cell	NOUN
dti-1349	53	27	membrane	membrane	NOUN
dti-1349	53	28	.	.	PUNCT
dti-1349	54	1	this	this	DET
dti-1349	54	2	antibody	antibody	NOUN
dti-1349	54	3	recognizes	recognize	VERB
dti-1349	54	4	and	and	CCONJ
dti-1349	54	5	inhibits	inhibit	VERB
dti-1349	54	6	the	the	DET
dti-1349	54	7	rest	rest	NOUN
dti-1349	54	8	of	of	ADP
dti-1349	54	9	the	the	DET
dti-1349	54	10	p	p	NOUN
dti-1349	54	11	-	-	PUNCT
dti-1349	54	12	gp	gp	NOUN
dti-1349	54	13	molecules	molecule	NOUN
dti-1349	54	14	only	only	ADV
dti-1349	54	15	in	in	ADP
dti-1349	54	16	the	the	DET
dti-1349	54	17	presence	presence	NOUN
dti-1349	54	18	of	of	ADP
dti-1349	54	19	certain	certain	ADJ
dti-1349	54	20	inhibitors	inhibitor	NOUN
dti-1349	54	21	,	,	PUNCT
dti-1349	54	22	including	include	VERB
dti-1349	54	23	vinblastine	vinblastine	NOUN
dti-1349	54	24	,	,	PUNCT
dti-1349	54	25	cyclosporine	cyclosporine	VERB
dti-1349	54	26	a	a	PRON
dti-1349	54	27	,	,	PUNCT
dti-1349	54	28	and	and	CCONJ
dti-1349	54	29	psc	psc	PROPN
dti-1349	54	30	833	833	NUM
dti-1349	54	31	(	(	PUNCT
dti-1349	54	32	valspodar	valspodar	PROPN
dti-1349	54	33	)	)	PUNCT
dti-1349	54	34	.	.	PUNCT
dti-1349	55	1	therefore	therefore	ADV
dti-1349	55	2	,	,	PUNCT
dti-1349	55	3	simultaneous	simultaneous	ADJ
dti-1349	55	4	application	application	NOUN
dti-1349	55	5	of	of	ADP
dti-1349	55	6	any	any	PRON
dti-1349	55	7	of	of	ADP
dti-1349	55	8	these	these	DET
dti-1349	55	9	inhibitors	inhibitor	NOUN
dti-1349	55	10	and	and	CCONJ
dti-1349	55	11	uic2	uic2	PROPN
dti-1349	55	12	can	can	AUX
dti-1349	55	13	enhance	enhance	VERB
dti-1349	55	14	accumulation	accumulation	NOUN
dti-1349	55	15	of	of	ADP
dti-1349	55	16	certain	certain	ADJ
dti-1349	55	17	substrates	substrate	NOUN
dti-1349	55	18	of	of	ADP
dti-1349	55	19	p	p	NOUN
dti-1349	55	20	-	-	PUNCT
dti-1349	55	21	gp	gp	NOUN
dti-1349	55	22	by	by	ADP
dti-1349	55	23	total	total	ADJ
dti-1349	55	24	inhibition	inhibition	NOUN
dti-1349	55	25	of	of	ADP
dti-1349	55	26	p	p	NOUN
dti-1349	55	27	-	-	PUNCT
dti-1349	55	28	gp	gp	NOUN
dti-1349	55	29	pump	pump	NOUN
dti-1349	55	30	activity.29	activity.29	NOUN
dti-1349	55	31	enhancement	enhancement	NOUN
dti-1349	55	32	of	of	ADP
dti-1349	55	33	bioavailability	bioavailability	NOUN
dti-1349	55	34	and	and	CCONJ
dti-1349	55	35	transport	transport	NOUN
dti-1349	55	36	even	even	ADV
dti-1349	55	37	though	though	SCONJ
dti-1349	55	38	p	p	NOUN
dti-1349	55	39	-	-	PUNCT
dti-1349	55	40	gp	gp	NOUN
dti-1349	55	41	decreases	decrease	VERB
dti-1349	55	42	drug	drug	NOUN
dti-1349	55	43	absorption	absorption	NOUN
dti-1349	55	44	of	of	ADP
dti-1349	55	45	all	all	PRON
dti-1349	55	46	of	of	ADP
dti-1349	55	47	its	its	PRON
dti-1349	55	48	substrates	substrate	NOUN
dti-1349	55	49	,	,	PUNCT
dti-1349	55	50	it	it	PRON
dti-1349	55	51	quantitatively	quantitatively	ADV
dti-1349	55	52	does	do	AUX
dti-1349	55	53	not	not	PART
dti-1349	55	54	have	have	VERB
dti-1349	55	55	an	an	DET
dti-1349	55	56	equal	equal	ADJ
dti-1349	55	57	significant	significant	ADJ
dti-1349	55	58	impact	impact	NOUN
dti-1349	55	59	on	on	ADP
dti-1349	55	60	overall	overall	ADJ
dti-1349	55	61	drug	drug	NOUN
dti-1349	55	62	absorption	absorption	NOUN
dti-1349	55	63	for	for	ADP
dti-1349	55	64	all	all	PRON
dti-1349	55	65	of	of	ADP
dti-1349	55	66	them	they	PRON
dti-1349	55	67	.	.	PUNCT
dti-1349	56	1	in	in	ADP
dti-1349	56	2	the	the	DET
dti-1349	56	3	case	case	NOUN
dti-1349	56	4	of	of	ADP
dti-1349	56	5	fast	fast	ADJ
dti-1349	56	6	absorbing	absorbing	ADJ
dti-1349	56	7	drugs	drug	NOUN
dti-1349	56	8	having	have	VERB
dti-1349	56	9	larger	large	ADJ
dti-1349	56	10	doses	dose	NOUN
dti-1349	56	11	,	,	PUNCT
dti-1349	56	12	efflux	efflux	VERB
dti-1349	56	13	by	by	ADP
dti-1349	56	14	p	p	NOUN
dti-1349	56	15	-	-	PUNCT
dti-1349	56	16	gp	gp	NOUN
dti-1349	56	17	poses	pose	VERB
dti-1349	56	18	less	less	ADJ
dti-1349	56	19	impact	impact	NOUN
dti-1349	56	20	on	on	ADP
dti-1349	56	21	drug	drug	NOUN
dti-1349	56	22	absorption	absorption	NOUN
dti-1349	56	23	and	and	CCONJ
dti-1349	56	24	therefore	therefore	ADV
dti-1349	56	25	is	be	AUX
dti-1349	56	26	not	not	PART
dti-1349	56	27	important	important	ADJ
dti-1349	56	28	in	in	ADP
dti-1349	56	29	terms	term	NOUN
dti-1349	56	30	of	of	ADP
dti-1349	56	31	bioavailability	bioavailability	NOUN
dti-1349	56	32	or	or	CCONJ
dti-1349	56	33	pharmacokinetic	pharmacokinetic	ADJ
dti-1349	56	34	properties	property	NOUN
dti-1349	56	35	.	.	PUNCT
dti-1349	57	1	this	this	PRON
dti-1349	57	2	is	be	AUX
dti-1349	57	3	because	because	SCONJ
dti-1349	57	4	the	the	DET
dti-1349	57	5	transport	transport	NOUN
dti-1349	57	6	activity	activity	NOUN
dti-1349	57	7	of	of	ADP
dti-1349	57	8	p	p	NOUN
dti-1349	57	9	-	-	PUNCT
dti-1349	57	10	gp	gp	NOUN
dti-1349	57	11	becomes	becomes	AUX
dti-1349	57	12	saturated	saturate	VERB
dti-1349	57	13	by	by	ADP
dti-1349	57	14	high	high	ADJ
dti-1349	57	15	concentrations	concentration	NOUN
dti-1349	57	16	of	of	ADP
dti-1349	57	17	drug	drug	NOUN
dti-1349	57	18	in	in	ADP
dti-1349	57	19	the	the	DET
dti-1349	57	20	intestinal	intestinal	ADJ
dti-1349	57	21	lumen	luman	NOUN
dti-1349	57	22	.	.	PUNCT
dti-1349	58	1	in	in	ADP
dti-1349	58	2	the	the	DET
dti-1349	58	3	case	case	NOUN
dti-1349	58	4	of	of	ADP
dti-1349	58	5	drugs	drug	NOUN
dti-1349	58	6	requiring	require	VERB
dti-1349	58	7	a	a	DET
dti-1349	58	8	very	very	ADV
dti-1349	58	9	small	small	ADJ
dti-1349	58	10	dose	dose	NOUN
dti-1349	58	11	for	for	ADP
dti-1349	58	12	their	their	PRON
dti-1349	58	13	pharmacological	pharmacological	ADJ
dti-1349	58	14	actions	action	NOUN
dti-1349	58	15	or	or	CCONJ
dti-1349	58	16	the	the	DET
dti-1349	58	17	drugs	drug	NOUN
dti-1349	58	18	that	that	PRON
dti-1349	58	19	have	have	VERB
dti-1349	58	20	very	very	ADV
dti-1349	58	21	slow	slow	ADJ
dti-1349	58	22	dissolution	dissolution	NOUN
dti-1349	58	23	and	and	CCONJ
dti-1349	58	24	diffusion	diffusion	NOUN
dti-1349	58	25	rates	rate	NOUN
dti-1349	58	26	,	,	PUNCT
dti-1349	58	27	p	p	NOUN
dti-1349	58	28	-	-	PUNCT
dti-1349	58	29	gp	gp	NOUN
dti-1349	58	30	mediated	mediate	VERB
dti-1349	58	31	drug	drug	NOUN
dti-1349	58	32	efflux	efflux	NOUN
dti-1349	58	33	greatly	greatly	ADV
dti-1349	58	34	interferes	interfere	VERB
dti-1349	58	35	with	with	ADP
dti-1349	58	36	their	their	PRON
dti-1349	58	37	delivery	delivery	NOUN
dti-1349	58	38	.	.	PUNCT
dti-1349	59	1	as	as	SCONJ
dti-1349	59	2	it	it	PRON
dti-1349	59	3	decreases	decrease	VERB
dti-1349	59	4	drug	drug	NOUN
dti-1349	59	5	absorption	absorption	NOUN
dti-1349	59	6	,	,	PUNCT
dti-1349	59	7	those	those	DET
dti-1349	59	8	small	small	ADJ
dti-1349	59	9	amounts	amount	NOUN
dti-1349	59	10	of	of	ADP
dti-1349	59	11	drugs	drug	NOUN
dti-1349	59	12	can	can	AUX
dti-1349	59	13	not	not	PART
dti-1349	59	14	reach	reach	VERB
dti-1349	59	15	the	the	DET
dti-1349	59	16	blood	blood	NOUN
dti-1349	59	17	circulation	circulation	NOUN
dti-1349	59	18	in	in	ADP
dti-1349	59	19	sufficient	sufficient	ADJ
dti-1349	59	20	quantity	quantity	NOUN
dti-1349	59	21	and	and	CCONJ
dti-1349	59	22	,	,	PUNCT
dti-1349	59	23	at	at	ADP
dti-1349	59	24	times	time	NOUN
dti-1349	59	25	,	,	PUNCT
dti-1349	59	26	can	can	AUX
dti-1349	59	27	be	be	AUX
dti-1349	59	28	life	life	NOUN
dti-1349	59	29	threatening	threaten	VERB
dti-1349	59	30	.	.	PUNCT
dti-1349	60	1	moreover	moreover	ADV
dti-1349	60	2	,	,	PUNCT
dti-1349	60	3	it	it	PRON
dti-1349	60	4	can	can	AUX
dti-1349	60	5	make	make	VERB
dti-1349	60	6	the	the	DET
dti-1349	60	7	sustained	sustain	VERB
dti-1349	60	8	release	release	NOUN
dti-1349	60	9	dosage	dosage	NOUN
dti-1349	60	10	forms	form	NOUN
dti-1349	60	11	of	of	ADP
dti-1349	60	12	the	the	DET
dti-1349	60	13	substrates	substrate	NOUN
dti-1349	60	14	completely	completely	ADV
dti-1349	60	15	ineffective	ineffective	ADJ
dti-1349	60	16	by	by	ADP
dti-1349	60	17	limiting	limit	VERB
dti-1349	60	18	their	their	PRON
dti-1349	60	19	absorptions.9	absorptions.9	PROPN
dti-1349	60	20	usually	usually	ADV
dti-1349	60	21	,	,	PUNCT
dti-1349	60	22	an	an	DET
dti-1349	60	23	inhibitor	inhibitor	NOUN
dti-1349	60	24	of	of	ADP
dti-1349	60	25	p	p	NOUN
dti-1349	60	26	-	-	PUNCT
dti-1349	60	27	gp	gp	NOUN
dti-1349	60	28	is	be	AUX
dti-1349	60	29	coadministered	coadministere	VERB
dti-1349	60	30	with	with	ADP
dti-1349	60	31	the	the	DET
dti-1349	60	32	drug	drug	NOUN
dti-1349	60	33	to	to	PART
dti-1349	60	34	enhance	enhance	VERB
dti-1349	60	35	drug	drug	NOUN
dti-1349	60	36	absorption.30,31	absorption.30,31	NOUN
dti-1349	60	37	methods	method	NOUN
dti-1349	60	38	are	be	AUX
dti-1349	60	39	being	be	AUX
dti-1349	60	40	developed	develop	VERB
dti-1349	60	41	in	in	ADP
dti-1349	60	42	preparing	prepare	VERB
dti-1349	60	43	clinically	clinically	ADV
dti-1349	60	44	useful	useful	ADJ
dti-1349	60	45	oral	oral	ADJ
dti-1349	60	46	formulations	formulation	NOUN
dti-1349	60	47	of	of	ADP
dti-1349	60	48	drugs	drug	NOUN
dti-1349	60	49	having	have	VERB
dti-1349	60	50	poor	poor	ADJ
dti-1349	60	51	oral	oral	ADJ
dti-1349	60	52	absorption	absorption	NOUN
dti-1349	60	53	,	,	PUNCT
dti-1349	60	54	which	which	PRON
dti-1349	60	55	are	be	AUX
dti-1349	60	56	administered	administer	VERB
dti-1349	60	57	only	only	ADV
dti-1349	60	58	by	by	ADP
dti-1349	60	59	parenteral	parenteral	ADJ
dti-1349	60	60	routes	route	NOUN
dti-1349	60	61	.	.	PUNCT
dti-1349	61	1	when	when	SCONJ
dti-1349	61	2	a	a	DET
dti-1349	61	3	drug	drug	NOUN
dti-1349	61	4	and	and	CCONJ
dti-1349	61	5	an	an	DET
dti-1349	61	6	inhibitor	inhibitor	NOUN
dti-1349	61	7	are	be	AUX
dti-1349	61	8	coadministered	coadministere	VERB
dti-1349	61	9	,	,	PUNCT
dti-1349	61	10	p	p	NOUN
dti-1349	61	11	-	-	PUNCT
dti-1349	61	12	gp	gp	NOUN
dti-1349	61	13	mediated	mediate	VERB
dti-1349	61	14	transport	transport	NOUN
dti-1349	61	15	mechanism	mechanism	NOUN
dti-1349	61	16	remains	remain	VERB
dti-1349	61	17	the	the	DET
dti-1349	61	18	same	same	ADJ
dti-1349	61	19	for	for	ADP
dti-1349	61	20	both	both	CCONJ
dti-1349	61	21	the	the	DET
dti-1349	61	22	drug	drug	NOUN
dti-1349	61	23	and	and	CCONJ
dti-1349	61	24	the	the	DET
dti-1349	61	25	inhibitor	inhibitor	NOUN
dti-1349	61	26	,	,	PUNCT
dti-1349	61	27	if	if	SCONJ
dti-1349	61	28	the	the	DET
dti-1349	61	29	inhibitor	inhibitor	NOUN
dti-1349	61	30	is	be	AUX
dti-1349	61	31	a	a	DET
dti-1349	61	32	substrate	substrate	NOUN
dti-1349	61	33	of	of	ADP
dti-1349	61	34	it	it	PRON
dti-1349	61	35	.	.	PUNCT
dti-1349	62	1	in	in	ADP
dti-1349	62	2	this	this	DET
dti-1349	62	3	process	process	NOUN
dti-1349	62	4	,	,	PUNCT
dti-1349	62	5	drug	drug	NOUN
dti-1349	62	6	and	and	CCONJ
dti-1349	62	7	inhibitor	inhibitor	NOUN
dti-1349	62	8	must	must	AUX
dti-1349	62	9	be	be	AUX
dti-1349	62	10	discriminable	discriminable	ADJ
dti-1349	62	11	by	by	ADP
dti-1349	62	12	p	p	NOUN
dti-1349	62	13	-	-	PUNCT
dti-1349	62	14	gp	gp	NOUN
dti-1349	62	15	at	at	ADP
dti-1349	62	16	molecular	molecular	ADJ
dti-1349	62	17	level	level	NOUN
dti-1349	62	18	as	as	SCONJ
dti-1349	62	19	drug	drug	NOUN
dti-1349	62	20	molecules	molecule	NOUN
dti-1349	62	21	should	should	AUX
dti-1349	62	22	not	not	PART
dti-1349	62	23	be	be	AUX
dti-1349	62	24	extruded	extrude	VERB
dti-1349	62	25	.	.	PUNCT
dti-1349	63	1	this	this	PRON
dti-1349	63	2	is	be	AUX
dti-1349	63	3	why	why	SCONJ
dti-1349	63	4	a	a	DET
dti-1349	63	5	large	large	ADJ
dti-1349	63	6	difference	difference	NOUN
dti-1349	63	7	between	between	ADP
dti-1349	63	8	the	the	DET
dti-1349	63	9	rate	rate	NOUN
dti-1349	63	10	of	of	ADP
dti-1349	63	11	efflux	efflux	NOUN
dti-1349	63	12	of	of	ADP
dti-1349	63	13	the	the	DET
dti-1349	63	14	substrate	substrate	NOUN
dti-1349	63	15	and	and	CCONJ
dti-1349	63	16	the	the	DET
dti-1349	63	17	inhibitor	inhibitor	NOUN
dti-1349	63	18	is	be	AUX
dti-1349	63	19	created	create	VERB
dti-1349	63	20	.	.	PUNCT
dti-1349	64	1	when	when	SCONJ
dti-1349	64	2	the	the	DET
dti-1349	64	3	inhibitor	inhibitor	NOUN
dti-1349	64	4	molecules	molecule	NOUN
dti-1349	64	5	are	be	AUX
dti-1349	64	6	effluxed	effluxe	VERB
dti-1349	64	7	,	,	PUNCT
dti-1349	64	8	they	they	PRON
dti-1349	64	9	rapidly	rapidly	ADV
dti-1349	64	10	bind	bind	VERB
dti-1349	64	11	to	to	ADP
dti-1349	64	12	the	the	DET
dti-1349	64	13	p	p	NOUN
dti-1349	64	14	-	-	PUNCT
dti-1349	64	15	gp	gp	NOUN
dti-1349	64	16	binding	bind	VERB
dti-1349	64	17	sites	site	NOUN
dti-1349	64	18	again	again	ADV
dti-1349	64	19	and	and	CCONJ
dti-1349	64	20	thus	thus	ADV
dti-1349	64	21	the	the	DET
dti-1349	64	22	inhibition	inhibition	NOUN
dti-1349	64	23	of	of	ADP
dti-1349	64	24	p	p	NOUN
dti-1349	64	25	-	-	PUNCT
dti-1349	64	26	gp	gp	NOUN
dti-1349	64	27	by	by	ADP
dti-1349	64	28	the	the	DET
dti-1349	64	29	modulators	modulator	NOUN
dti-1349	64	30	is	be	AUX
dti-1349	64	31	cycled	cycle	VERB
dti-1349	64	32	repeatedly	repeatedly	ADV
dti-1349	64	33	,	,	PUNCT
dti-1349	64	34	preventing	prevent	VERB
dti-1349	64	35	efflux	efflux	NOUN
dti-1349	64	36	of	of	ADP
dti-1349	64	37	drugs	drug	NOUN
dti-1349	64	38	.	.	PUNCT
dti-1349	65	1	this	this	DET
dti-1349	65	2	process	process	NOUN
dti-1349	65	3	depends	depend	VERB
dti-1349	65	4	on	on	ADP
dti-1349	65	5	the	the	DET
dti-1349	65	6	hydrophobicity	hydrophobicity	NOUN
dti-1349	65	7	of	of	ADP
dti-1349	65	8	the	the	DET
dti-1349	65	9	compounds.32,33	compounds.32,33	PROPN
dti-1349	65	10	hm30181	hm30181	PROPN
dti-1349	65	11	,	,	PUNCT
dti-1349	65	12	a	a	DET
dti-1349	65	13	newly	newly	ADV
dti-1349	65	14	developed	develop	VERB
dti-1349	65	15	third	third	ADJ
dti-1349	65	16	generation	generation	NOUN
dti-1349	65	17	p	p	NOUN
dti-1349	65	18	-	-	PUNCT
dti-1349	65	19	gp	gp	NOUN
dti-1349	65	20	inhibitor	inhibitor	NOUN
dti-1349	65	21	,	,	PUNCT
dti-1349	65	22	showed	show	VERB
dti-1349	65	23	promising	promising	ADJ
dti-1349	65	24	results	result	NOUN
dti-1349	65	25	for	for	ADP
dti-1349	65	26	increasing	increase	VERB
dti-1349	65	27	oral	oral	ADJ
dti-1349	65	28	absorption	absorption	NOUN
dti-1349	65	29	of	of	ADP
dti-1349	65	30	some	some	DET
dti-1349	65	31	drugs	drug	NOUN
dti-1349	65	32	in	in	ADP
dti-1349	65	33	recent	recent	ADJ
dti-1349	65	34	studies	study	NOUN
dti-1349	65	35	.	.	PUNCT
dti-1349	66	1	kwak	kwak	PROPN
dti-1349	66	2	et	et	PROPN
dti-1349	66	3	al34	al34	PROPN
dti-1349	66	4	examined	examine	VERB
dti-1349	66	5	its	its	PRON
dti-1349	66	6	pharmacologic	pharmacologic	ADJ
dti-1349	66	7	characteristics	characteristic	NOUN
dti-1349	66	8	and	and	CCONJ
dti-1349	66	9	it	it	PRON
dti-1349	66	10	showed	show	VERB
dti-1349	66	11	the	the	DET
dti-1349	66	12	highest	high	ADJ
dti-1349	66	13	potency	potency	NOUN
dti-1349	66	14	among	among	ADP
dti-1349	66	15	several	several	ADJ
dti-1349	66	16	p	p	NOUN
dti-1349	66	17	-	-	PUNCT
dti-1349	66	18	gp	gp	NOUN
dti-1349	66	19	inhibitors	inhibitor	NOUN
dti-1349	66	20	,	,	PUNCT
dti-1349	66	21	including	include	VERB
dti-1349	66	22	cyclosporin	cyclosporin	NOUN
dti-1349	66	23	a	a	NOUN
dti-1349	66	24	,	,	PUNCT
dti-1349	66	25	xr9576	xr9576	PROPN
dti-1349	66	26	,	,	PUNCT
dti-1349	66	27	and	and	CCONJ
dti-1349	66	28	gf120918	gf120918	NOUN
dti-1349	66	29	.	.	PUNCT
dti-1349	67	1	the	the	DET
dti-1349	67	2	inhibitory	inhibitory	ADJ
dti-1349	67	3	activity	activity	NOUN
dti-1349	67	4	of	of	ADP
dti-1349	67	5	hm30181	hm30181	NOUN
dti-1349	67	6	was	be	AUX
dti-1349	67	7	highly	highly	ADV
dti-1349	67	8	selective	selective	ADJ
dti-1349	67	9	to	to	ADP
dti-1349	67	10	p	p	NOUN
dti-1349	67	11	-	-	PUNCT
dti-1349	67	12	gp	gp	NOUN
dti-1349	67	13	and	and	CCONJ
dti-1349	67	14	it	it	PRON
dti-1349	67	15	did	do	AUX
dti-1349	67	16	not	not	PART
dti-1349	67	17	inhibit	inhibit	VERB
dti-1349	67	18	other	other	ADJ
dti-1349	67	19	abc	abc	PROPN
dti-1349	67	20	transporters	transporter	NOUN
dti-1349	67	21	.	.	PUNCT
dti-1349	68	1	its	its	PRON
dti-1349	68	2	coadministration	coadministration	NOUN
dti-1349	68	3	(	(	PUNCT
dti-1349	68	4	10	10	NUM
dti-1349	68	5	mg	mg	NUM
dti-1349	68	6	/	/	SYM
dti-1349	68	7	kg	kg	NOUN
dti-1349	68	8	)	)	PUNCT
dti-1349	68	9	greatly	greatly	ADV
dti-1349	68	10	increased	increase	VERB
dti-1349	68	11	oral	oral	ADJ
dti-1349	68	12	bioavailability	bioavailability	NOUN
dti-1349	68	13	of	of	ADP
dti-1349	68	14	paclitaxel	paclitaxel	PROPN
dti-1349	68	15	from	from	ADP
dti-1349	68	16	3.4	3.4	NUM
dti-1349	68	17	%	%	NOUN
dti-1349	68	18	to	to	ADP
dti-1349	68	19	41.3	41.3	NUM
dti-1349	68	20	%	%	NOUN
dti-1349	68	21	in	in	ADP
dti-1349	68	22	rats	rat	NOUN
dti-1349	68	23	.	.	PUNCT
dti-1349	69	1	importantly	importantly	ADV
dti-1349	69	2	,	,	PUNCT
dti-1349	69	3	oral	oral	ADJ
dti-1349	69	4	coadministration	coadministration	NOUN
dti-1349	69	5	of	of	ADP
dti-1349	69	6	paclitaxel	paclitaxel	PROPN
dti-1349	69	7	and	and	CCONJ
dti-1349	69	8	hm30181showed	hm30181showe	VERB
dti-1349	69	9	a	a	DET
dti-1349	69	10	tumor	tumor	NOUN
dti-1349	69	11	inhibitory	inhibitory	ADJ
dti-1349	69	12	strength	strength	NOUN
dti-1349	69	13	equal	equal	ADJ
dti-1349	69	14	or	or	CCONJ
dti-1349	69	15	superior	superior	ADJ
dti-1349	69	16	to	to	ADP
dti-1349	69	17	that	that	PRON
dti-1349	69	18	of	of	ADP
dti-1349	69	19	intravenous	intravenous	ADJ
dti-1349	69	20	paclitaxel	paclitaxel	NOUN
dti-1349	69	21	in	in	ADP
dti-1349	69	22	the	the	DET
dti-1349	69	23	xenograft	xenograft	NOUN
dti-1349	69	24	model	model	NOUN
dti-1349	69	25	in	in	ADP
dti-1349	69	26	nude	nude	ADJ
dti-1349	69	27	mice.34	mice.34	NOUN
dti-1349	69	28	p	p	NOUN
dti-1349	69	29	-	-	PUNCT
dti-1349	69	30	gp	gp	NOUN
dti-1349	69	31	inhibitors	inhibitor	NOUN
dti-1349	69	32	may	may	AUX
dti-1349	69	33	have	have	VERB
dti-1349	69	34	a	a	DET
dti-1349	69	35	great	great	ADJ
dti-1349	69	36	impact	impact	NOUN
dti-1349	69	37	on	on	ADP
dti-1349	69	38	altering	alter	VERB
dti-1349	69	39	pharmacokinetics	pharmacokinetic	NOUN
dti-1349	69	40	of	of	ADP
dti-1349	69	41	a	a	DET
dti-1349	69	42	drug.10	drug.10	NOUN
dti-1349	69	43	since	since	SCONJ
dti-1349	69	44	p	p	NOUN
dti-1349	69	45	-	-	PUNCT
dti-1349	69	46	gp	gp	NOUN
dti-1349	69	47	molecules	molecule	NOUN
dti-1349	69	48	are	be	AUX
dti-1349	69	49	present	present	ADJ
dti-1349	69	50	in	in	ADP
dti-1349	69	51	many	many	ADJ
dti-1349	69	52	organs	organ	NOUN
dti-1349	69	53	like	like	ADP
dti-1349	69	54	bbb	bbb	PROPN
dti-1349	69	55	,	,	PUNCT
dti-1349	69	56	kidney	kidney	NOUN
dti-1349	69	57	proximal	proximal	ADJ
dti-1349	69	58	tubule	tubule	NOUN
dti-1349	69	59	,	,	PUNCT
dti-1349	69	60	and	and	CCONJ
dti-1349	69	61	bile	bile	NOUN
dti-1349	69	62	ductule	ductule	NOUN
dti-1349	69	63	,	,	PUNCT
dti-1349	69	64	their	their	PRON
dti-1349	69	65	inhibition	inhibition	NOUN
dti-1349	69	66	can	can	AUX
dti-1349	69	67	potentially	potentially	ADV
dti-1349	69	68	improve	improve	VERB
dti-1349	69	69	not	not	PART
dti-1349	69	70	only	only	ADV
dti-1349	69	71	the	the	DET
dti-1349	69	72	absorption	absorption	NOUN
dti-1349	69	73	,	,	PUNCT
dti-1349	69	74	but	but	CCONJ
dti-1349	69	75	also	also	ADV
dti-1349	69	76	the	the	DET
dti-1349	69	77	distribution	distribution	NOUN
dti-1349	69	78	,	,	PUNCT
dti-1349	69	79	metabolism	metabolism	NOUN
dti-1349	69	80	,	,	PUNCT
dti-1349	69	81	and	and	CCONJ
dti-1349	69	82	elimination	elimination	NOUN
dti-1349	69	83	of	of	ADP
dti-1349	69	84	their	their	PRON
dti-1349	69	85	substrates.10,35	substrates.10,35	ADJ
dti-1349	69	86	asperen	asperen	NOUN
dti-1349	70	1	et	et	PROPN
dti-1349	70	2	al36	al36	PROPN
dti-1349	70	3	observed	observe	VERB
dti-1349	70	4	a	a	DET
dti-1349	70	5	10	10	NUM
dti-1349	70	6	-	-	ADJ
dti-1349	70	7	fold	fold	ADJ
dti-1349	70	8	increased	increase	VERB
dti-1349	70	9	oral	oral	ADJ
dti-1349	70	10	bioavailability	bioavailability	NOUN
dti-1349	70	11	of	of	ADP
dti-1349	70	12	paclitaxel	paclitaxel	PROPN
dti-1349	70	13	in	in	ADP
dti-1349	70	14	mice	mouse	NOUN
dti-1349	70	15	administered	administer	VERB
dti-1349	70	16	along	along	ADP
dti-1349	70	17	with	with	ADP
dti-1349	70	18	a	a	DET
dti-1349	70	19	p	p	NOUN
dti-1349	70	20	-	-	PUNCT
dti-1349	70	21	gp	gp	NOUN
dti-1349	70	22	blocker	blocker	NOUN
dti-1349	70	23	(	(	PUNCT
dti-1349	70	24	valspodar	valspodar	PROPN
dti-1349	70	25	)	)	PUNCT
dti-1349	70	26	.	.	PUNCT
dti-1349	71	1	sugie	sugie	PROPN
dti-1349	71	2	et	et	PROPN
dti-1349	71	3	al37	al37	PROPN
dti-1349	71	4	articulated	articulate	VERB
dti-1349	71	5	that	that	DET
dti-1349	71	6	coadministration	coadministration	NOUN
dti-1349	71	7	of	of	ADP
dti-1349	71	8	azithromycin	azithromycin	PROPN
dti-1349	71	9	and	and	CCONJ
dti-1349	71	10	cyclosporine	cyclosporine	NOUN
dti-1349	71	11	resulted	result	VERB
dti-1349	71	12	in	in	ADP
dti-1349	71	13	decreased	decrease	VERB
dti-1349	71	14	billiary	billiary	ADJ
dti-1349	71	15	excretion	excretion	NOUN
dti-1349	71	16	of	of	ADP
dti-1349	71	17	azithromycin	azithromycin	PROPN
dti-1349	71	18	.	.	PUNCT
dti-1349	72	1	bbb	bbb	PROPN
dti-1349	72	2	is	be	AUX
dti-1349	72	3	considered	consider	VERB
dti-1349	72	4	as	as	ADP
dti-1349	72	5	the	the	DET
dti-1349	72	6	main	main	ADJ
dti-1349	72	7	barrier	barrier	NOUN
dti-1349	72	8	to	to	PART
dti-1349	72	9	prevent	prevent	VERB
dti-1349	72	10	drugs	drug	NOUN
dti-1349	72	11	entering	enter	VERB
dti-1349	72	12	the	the	DET
dti-1349	72	13	central	central	ADJ
dti-1349	72	14	nervous	nervous	ADJ
dti-1349	72	15	system	system	NOUN
dti-1349	72	16	(	(	PUNCT
dti-1349	72	17	cns	cns	NOUN
dti-1349	72	18	)	)	PUNCT
dti-1349	72	19	.	.	PUNCT
dti-1349	73	1	presence	presence	NOUN
dti-1349	73	2	of	of	ADP
dti-1349	73	3	p	p	NOUN
dti-1349	73	4	-	-	PUNCT
dti-1349	73	5	gp	gp	NOUN
dti-1349	73	6	in	in	ADP
dti-1349	73	7	the	the	DET
dti-1349	73	8	bbb	bbb	PROPN
dti-1349	73	9	makes	make	VERB
dti-1349	73	10	it	it	PRON
dti-1349	73	11	additionally	additionally	ADV
dti-1349	73	12	difficult	difficult	ADJ
dti-1349	73	13	,	,	PUNCT
dti-1349	73	14	effluxing	effluxe	VERB
dti-1349	73	15	the	the	DET
dti-1349	73	16	drug	drug	NOUN
dti-1349	73	17	molecules	molecule	NOUN
dti-1349	73	18	from	from	ADP
dti-1349	73	19	the	the	DET
dti-1349	73	20	cns.2,38	cns.2,38	PROPN
dti-1349	73	21	p	p	NOUN
dti-1349	73	22	-	-	PUNCT
dti-1349	73	23	gp	gp	NOUN
dti-1349	73	24	inhibition	inhibition	NOUN
dti-1349	73	25	can	can	AUX
dti-1349	73	26	prevent	prevent	VERB
dti-1349	73	27	p	p	NOUN
dti-1349	73	28	-	-	PUNCT
dti-1349	73	29	gp	gp	NOUN
dti-1349	73	30	mediated	mediate	VERB
dti-1349	73	31	drug	drug	NOUN
dti-1349	73	32	efflux	efflux	NOUN
dti-1349	73	33	and	and	CCONJ
dti-1349	73	34	assist	assist	VERB
dti-1349	73	35	the	the	DET
dti-1349	73	36	substrate	substrate	NOUN
dti-1349	73	37	molecules	molecule	NOUN
dti-1349	73	38	to	to	PART
dti-1349	73	39	enter	enter	VERB
dti-1349	73	40	the	the	DET
dti-1349	73	41	cns	cns	PROPN
dti-1349	73	42	.	.	PUNCT
dti-1349	74	1	kemper	kemper	PROPN
dti-1349	74	2	et	et	PROPN
dti-1349	74	3	al38	al38	PROPN
dti-1349	74	4	reported	report	VERB
dti-1349	74	5	a	a	DET
dti-1349	74	6	5	5	NUM
dti-1349	74	7	-	-	ADJ
dti-1349	74	8	fold	fold	ADJ
dti-1349	74	9	increase	increase	NOUN
dti-1349	74	10	in	in	ADP
dti-1349	74	11	brain	brain	NOUN
dti-1349	74	12	uptake	uptake	NOUN
dti-1349	74	13	of	of	ADP
dti-1349	74	14	paclitaxel	paclitaxel	PROPN
dti-1349	74	15	by	by	ADP
dti-1349	74	16	gf120918	gf120918	PROPN
dti-1349	74	17	(	(	PUNCT
dti-1349	74	18	elacridar	elacridar	PROPN
dti-1349	74	19	)	)	PUNCT
dti-1349	74	20	,	,	PUNCT
dti-1349	74	21	a	a	DET
dti-1349	74	22	third	third	ADJ
dti-1349	74	23	http://www.la-press.com	http://www.la-press.com	X
dti-1349	74	24	p	p	X
dti-1349	74	25	-	-	PUNCT
dti-1349	74	26	glycoprotein	glycoprotein	NOUN
dti-1349	74	27	inhibition	inhibition	NOUN
dti-1349	74	28	for	for	ADP
dti-1349	74	29	optimal	optimal	ADJ
dti-1349	74	30	drug	drug	NOUN
dti-1349	74	31	delivery	delivery	NOUN
dti-1349	74	32	drug	drug	NOUN
dti-1349	74	33	target	target	NOUN
dti-1349	74	34	insights	insight	NOUN
dti-1349	74	35	2013:7	2013:7	NUM
dti-1349	74	36	31	31	NUM
dti-1349	74	37	generation	generation	NOUN
dti-1349	74	38	p	p	NOUN
dti-1349	74	39	-	-	PUNCT
dti-1349	74	40	gp	gp	NOUN
dti-1349	74	41	inhibitor	inhibitor	NOUN
dti-1349	74	42	.	.	PUNCT
dti-1349	75	1	a	a	DET
dti-1349	75	2	reduced	reduced	ADJ
dti-1349	75	3	clearance	clearance	NOUN
dti-1349	75	4	of	of	ADP
dti-1349	75	5	paclitaxel	paclitaxel	PROPN
dti-1349	75	6	was	be	AUX
dti-1349	75	7	noticed	notice	VERB
dti-1349	75	8	,	,	PUNCT
dti-1349	75	9	assuming	assume	VERB
dti-1349	75	10	the	the	DET
dti-1349	75	11	inhibition	inhibition	NOUN
dti-1349	75	12	of	of	ADP
dti-1349	75	13	p	p	NOUN
dti-1349	75	14	-	-	PUNCT
dti-1349	75	15	gp	gp	NOUN
dti-1349	75	16	in	in	ADP
dti-1349	75	17	elimination	elimination	NOUN
dti-1349	75	18	pathway.38	pathway.38	PROPN
dti-1349	75	19	p	p	NOUN
dti-1349	75	20	-	-	PUNCT
dti-1349	75	21	gp	gp	NOUN
dti-1349	75	22	inhibition	inhibition	NOUN
dti-1349	75	23	can	can	AUX
dti-1349	75	24	also	also	ADV
dti-1349	75	25	increase	increase	VERB
dti-1349	75	26	the	the	DET
dti-1349	75	27	half	half	ADJ
dti-1349	75	28	-	-	PUNCT
dti-1349	75	29	lives	life	NOUN
dti-1349	75	30	of	of	ADP
dti-1349	75	31	the	the	DET
dti-1349	75	32	substrates	substrate	NOUN
dti-1349	75	33	as	as	SCONJ
dti-1349	75	34	the	the	DET
dti-1349	75	35	inhibition	inhibition	NOUN
dti-1349	75	36	may	may	AUX
dti-1349	75	37	reduce	reduce	VERB
dti-1349	75	38	billiary	billiary	NOUN
dti-1349	75	39	excretion	excretion	NOUN
dti-1349	75	40	and	and	CCONJ
dti-1349	75	41	the	the	DET
dti-1349	75	42	clearance	clearance	NOUN
dti-1349	75	43	of	of	ADP
dti-1349	75	44	the	the	DET
dti-1349	75	45	substrates	substrate	NOUN
dti-1349	75	46	in	in	ADP
dti-1349	75	47	kidney	kidney	NOUN
dti-1349	75	48	proximal	proximal	ADJ
dti-1349	75	49	tubule	tubule	NOUN
dti-1349	75	50	,	,	PUNCT
dti-1349	75	51	increasing	increase	VERB
dti-1349	75	52	renal	renal	ADJ
dti-1349	75	53	reuptake	reuptake	NOUN
dti-1349	75	54	.	.	PUNCT
dti-1349	76	1	orally	orally	ADV
dti-1349	76	2	coadministered	coadministere	VERB
dti-1349	76	3	doxorubicin	doxorubicin	PROPN
dti-1349	76	4	and	and	CCONJ
dti-1349	76	5	verapamil	verapamil	NOUN
dti-1349	76	6	have	have	AUX
dti-1349	76	7	shown	show	VERB
dti-1349	76	8	to	to	PART
dti-1349	76	9	increase	increase	VERB
dti-1349	76	10	peak	peak	NOUN
dti-1349	76	11	plasma	plasma	NOUN
dti-1349	76	12	level	level	NOUN
dti-1349	76	13	,	,	PUNCT
dti-1349	76	14	prolong	prolong	VERB
dti-1349	76	15	elimination	elimination	NOUN
dti-1349	76	16	of	of	ADP
dti-1349	76	17	half	half	ADJ
dti-1349	76	18	-	-	PUNCT
dti-1349	76	19	life	life	NOUN
dti-1349	76	20	,	,	PUNCT
dti-1349	76	21	and	and	CCONJ
dti-1349	76	22	increase	increase	VERB
dti-1349	76	23	volume	volume	NOUN
dti-1349	76	24	of	of	ADP
dti-1349	76	25	distribution	distribution	NOUN
dti-1349	76	26	of	of	ADP
dti-1349	76	27	doxorubicin	doxorubicin	PROPN
dti-1349	76	28	after	after	ADP
dti-1349	76	29	oral	oral	ADJ
dti-1349	76	30	administration.39	administration.39	NOUN
dti-1349	76	31	both	both	CCONJ
dti-1349	76	32	natural	natural	ADJ
dti-1349	76	33	and	and	CCONJ
dti-1349	76	34	synthetic	synthetic	ADJ
dti-1349	76	35	inhibitors	inhibitor	NOUN
dti-1349	76	36	can	can	AUX
dti-1349	76	37	be	be	AUX
dti-1349	76	38	coadministered	coadministere	VERB
dti-1349	76	39	with	with	ADP
dti-1349	76	40	drugs	drug	NOUN
dti-1349	76	41	in	in	ADP
dti-1349	76	42	oral	oral	ADJ
dti-1349	76	43	dosage	dosage	NOUN
dti-1349	76	44	forms	form	NOUN
dti-1349	76	45	including	include	VERB
dti-1349	76	46	polyethylene	polyethylene	NOUN
dti-1349	76	47	glycol	glycol	NOUN
dti-1349	76	48	(	(	PUNCT
dti-1349	76	49	peg	peg	NOUN
dti-1349	76	50	)	)	PUNCT
dti-1349	76	51	based	base	VERB
dti-1349	76	52	surfactants	surfactant	NOUN
dti-1349	76	53	,	,	PUNCT
dti-1349	76	54	anionic	anionic	ADJ
dti-1349	76	55	gums	gum	NOUN
dti-1349	76	56	,	,	PUNCT
dti-1349	76	57	sodium	sodium	NOUN
dti-1349	76	58	alginate	alginate	NOUN
dti-1349	76	59	,	,	PUNCT
dti-1349	76	60	poloxamers	poloxamer	NOUN
dti-1349	76	61	,	,	PUNCT
dti-1349	76	62	thiomers	thiomer	NOUN
dti-1349	76	63	,	,	PUNCT
dti-1349	76	64	dendrimers	dendrimer	NOUN
dti-1349	76	65	,	,	PUNCT
dti-1349	76	66	etc	etc	X
dti-1349	76	67	.	.	X
dti-1349	77	1	among	among	ADP
dti-1349	77	2	these	these	DET
dti-1349	77	3	inhibitors	inhibitor	NOUN
dti-1349	77	4	,	,	PUNCT
dti-1349	77	5	surfactants	surfactant	NOUN
dti-1349	77	6	are	be	AUX
dti-1349	77	7	considered	consider	VERB
dti-1349	77	8	to	to	PART
dti-1349	77	9	be	be	AUX
dti-1349	77	10	the	the	DET
dti-1349	77	11	better	well	ADJ
dti-1349	77	12	choice	choice	NOUN
dti-1349	77	13	as	as	SCONJ
dti-1349	77	14	they	they	PRON
dti-1349	77	15	were	be	AUX
dti-1349	77	16	already	already	ADV
dti-1349	77	17	approved	approve	VERB
dti-1349	77	18	for	for	ADP
dti-1349	77	19	routine	routine	ADJ
dti-1349	77	20	use	use	NOUN
dti-1349	77	21	in	in	ADP
dti-1349	77	22	pharmaceutical	pharmaceutical	ADJ
dti-1349	77	23	formulations	formulation	NOUN
dti-1349	77	24	.	.	PUNCT
dti-1349	78	1	these	these	DET
dti-1349	78	2	surfactants	surfactant	NOUN
dti-1349	78	3	act	act	VERB
dti-1349	78	4	by	by	ADP
dti-1349	78	5	altering	alter	VERB
dti-1349	78	6	integrity	integrity	NOUN
dti-1349	78	7	of	of	ADP
dti-1349	78	8	membrane	membrane	NOUN
dti-1349	78	9	lipids	lipid	NOUN
dti-1349	78	10	by	by	ADP
dti-1349	78	11	changing	change	VERB
dti-1349	78	12	the	the	DET
dti-1349	78	13	secondary	secondary	ADJ
dti-1349	78	14	and	and	CCONJ
dti-1349	78	15	tertiary	tertiary	ADJ
dti-1349	78	16	structure	structure	NOUN
dti-1349	78	17	.	.	PUNCT
dti-1349	79	1	thus	thus	ADV
dti-1349	79	2	the	the	DET
dti-1349	79	3	function	function	NOUN
dti-1349	79	4	of	of	ADP
dti-1349	79	5	p	p	NOUN
dti-1349	79	6	-	-	PUNCT
dti-1349	79	7	gp	gp	NOUN
dti-1349	79	8	is	be	AUX
dti-1349	79	9	hampered	hamper	VERB
dti-1349	79	10	due	due	ADP
dti-1349	79	11	to	to	ADP
dti-1349	79	12	disturbance	disturbance	NOUN
dti-1349	79	13	in	in	ADP
dti-1349	79	14	hydrophobic	hydrophobic	NOUN
dti-1349	79	15	environment.10,40	environment.10,40	NOUN
dti-1349	79	16	antimicrobial	antimicrobial	ADJ
dti-1349	79	17	therapy	therapy	NOUN
dti-1349	79	18	drug	drug	NOUN
dti-1349	79	19	efflux	efflux	NOUN
dti-1349	79	20	is	be	AUX
dti-1349	79	21	a	a	DET
dti-1349	79	22	common	common	ADJ
dti-1349	79	23	mechanism	mechanism	NOUN
dti-1349	79	24	of	of	ADP
dti-1349	79	25	resistance	resistance	NOUN
dti-1349	79	26	in	in	ADP
dti-1349	79	27	microorganisms	microorganism	NOUN
dti-1349	79	28	,	,	PUNCT
dti-1349	79	29	along	along	ADP
dti-1349	79	30	the	the	DET
dti-1349	79	31	same	same	ADJ
dti-1349	79	32	lines	line	NOUN
dti-1349	79	33	as	as	ADP
dti-1349	79	34	target	target	NOUN
dti-1349	79	35	modification	modification	NOUN
dti-1349	79	36	or	or	CCONJ
dti-1349	79	37	production	production	NOUN
dti-1349	79	38	of	of	ADP
dti-1349	79	39	antibiotic	antibiotic	ADJ
dti-1349	79	40	inactivating	inactivating	NOUN
dti-1349	79	41	enzymes	enzyme	NOUN
dti-1349	79	42	.	.	PUNCT
dti-1349	80	1	efflux	efflux	NOUN
dti-1349	80	2	pumps	pump	NOUN
dti-1349	80	3	are	be	AUX
dti-1349	80	4	now	now	ADV
dti-1349	80	5	recognized	recognize	VERB
dti-1349	80	6	as	as	ADP
dti-1349	80	7	one	one	NUM
dti-1349	80	8	of	of	ADP
dti-1349	80	9	the	the	DET
dti-1349	80	10	most	most	ADV
dti-1349	80	11	important	important	ADJ
dti-1349	80	12	factors	factor	NOUN
dti-1349	80	13	in	in	ADP
dti-1349	80	14	accumulation	accumulation	NOUN
dti-1349	80	15	of	of	ADP
dti-1349	80	16	antimicrobials	antimicrobial	NOUN
dti-1349	80	17	in	in	ADP
dti-1349	80	18	all	all	DET
dti-1349	80	19	cell	cell	NOUN
dti-1349	80	20	types	type	NOUN
dti-1349	80	21	,	,	PUNCT
dti-1349	80	22	from	from	ADP
dti-1349	80	23	prokaryotes	prokaryote	NOUN
dti-1349	80	24	to	to	ADP
dti-1349	80	25	superior	superior	ADJ
dti-1349	80	26	eukaryotes	eukaryote	NOUN
dti-1349	80	27	.	.	PUNCT
dti-1349	81	1	mdr	mdr	PROPN
dti-1349	81	2	,	,	PUNCT
dti-1349	81	3	mediated	mediate	VERB
dti-1349	81	4	through	through	ADP
dti-1349	81	5	efflux	efflux	NOUN
dti-1349	81	6	pumps	pump	NOUN
dti-1349	81	7	,	,	PUNCT
dti-1349	81	8	has	have	AUX
dti-1349	81	9	been	be	AUX
dti-1349	81	10	described	describe	VERB
dti-1349	81	11	for	for	ADP
dti-1349	81	12	various	various	ADJ
dti-1349	81	13	organisms	organism	NOUN
dti-1349	81	14	,	,	PUNCT
dti-1349	81	15	including	include	VERB
dti-1349	81	16	bacteria	bacteria	NOUN
dti-1349	81	17	,	,	PUNCT
dti-1349	81	18	fungi	fungus	NOUN
dti-1349	81	19	,	,	PUNCT
dti-1349	81	20	and	and	CCONJ
dti-1349	81	21	protozoa	protozoan	NOUN
dti-1349	81	22	.	.	PUNCT
dti-1349	82	1	all	all	DET
dti-1349	82	2	transporters	transporter	NOUN
dti-1349	82	3	,	,	PUNCT
dti-1349	82	4	but	but	CCONJ
dti-1349	82	5	the	the	DET
dti-1349	82	6	abc	abc	PROPN
dti-1349	82	7	family	family	NOUN
dti-1349	82	8	,	,	PUNCT
dti-1349	82	9	function	function	VERB
dti-1349	82	10	as	as	ADP
dti-1349	82	11	secondary	secondary	ADJ
dti-1349	82	12	transporters	transporter	NOUN
dti-1349	82	13	.	.	PUNCT
dti-1349	83	1	p	p	X
dti-1349	83	2	-	-	PUNCT
dti-1349	83	3	gp	gp	NOUN
dti-1349	83	4	is	be	AUX
dti-1349	83	5	one	one	NUM
dti-1349	83	6	of	of	ADP
dti-1349	83	7	the	the	DET
dti-1349	83	8	main	main	ADJ
dti-1349	83	9	abc	abc	PROPN
dti-1349	83	10	transporters	transporter	NOUN
dti-1349	83	11	that	that	PRON
dti-1349	83	12	is	be	AUX
dti-1349	83	13	greatly	greatly	ADV
dti-1349	83	14	responsible	responsible	ADJ
dti-1349	83	15	for	for	ADP
dti-1349	83	16	mdr	mdr	PROPN
dti-1349	83	17	in	in	ADP
dti-1349	83	18	microorganisms.41–43	microorganisms.41–43	PROPN
dti-1349	83	19	p	p	PROPN
dti-1349	83	20	-	-	PUNCT
dti-1349	83	21	gp	gp	NOUN
dti-1349	83	22	molecules	molecule	NOUN
dti-1349	83	23	prevent	prevent	VERB
dti-1349	83	24	antimicrobial	antimicrobial	ADJ
dti-1349	83	25	agents	agent	NOUN
dti-1349	83	26	from	from	ADP
dti-1349	83	27	entering	enter	VERB
dti-1349	83	28	the	the	DET
dti-1349	83	29	microorganisms	microorganism	NOUN
dti-1349	83	30	.	.	PUNCT
dti-1349	84	1	they	they	PRON
dti-1349	84	2	reduce	reduce	VERB
dti-1349	84	3	intracellular	intracellular	ADJ
dti-1349	84	4	drug	drug	NOUN
dti-1349	84	5	concentrations	concentration	NOUN
dti-1349	84	6	and	and	CCONJ
dti-1349	84	7	thereby	thereby	ADV
dti-1349	84	8	impede	impede	VERB
dti-1349	84	9	accessibility	accessibility	NOUN
dti-1349	84	10	of	of	ADP
dti-1349	84	11	drugs	drug	NOUN
dti-1349	84	12	to	to	ADP
dti-1349	84	13	their	their	PRON
dti-1349	84	14	sites	site	NOUN
dti-1349	84	15	of	of	ADP
dti-1349	84	16	action	action	NOUN
dti-1349	84	17	,	,	PUNCT
dti-1349	84	18	ultimately	ultimately	ADV
dti-1349	84	19	leading	lead	VERB
dti-1349	84	20	to	to	ADP
dti-1349	84	21	reduced	reduce	VERB
dti-1349	84	22	susceptibility	susceptibility	NOUN
dti-1349	84	23	.	.	PUNCT
dti-1349	85	1	this	this	DET
dti-1349	85	2	transport	transport	NOUN
dti-1349	85	3	mechanism	mechanism	NOUN
dti-1349	85	4	may	may	AUX
dti-1349	85	5	result	result	VERB
dti-1349	85	6	in	in	ADP
dti-1349	85	7	treatment	treatment	NOUN
dti-1349	85	8	failure	failure	NOUN
dti-1349	85	9	in	in	ADP
dti-1349	85	10	many	many	ADJ
dti-1349	85	11	infectious	infectious	ADJ
dti-1349	85	12	diseases.44,45	diseases.44,45	NOUN
dti-1349	85	13	mdr	mdr	PROPN
dti-1349	85	14	is	be	AUX
dti-1349	85	15	a	a	DET
dti-1349	85	16	major	major	ADJ
dti-1349	85	17	problem	problem	NOUN
dti-1349	85	18	in	in	ADP
dti-1349	85	19	bacterial	bacterial	ADJ
dti-1349	85	20	infections	infection	NOUN
dti-1349	85	21	because	because	SCONJ
dti-1349	85	22	it	it	PRON
dti-1349	85	23	limits	limit	VERB
dti-1349	85	24	the	the	DET
dti-1349	85	25	option	option	NOUN
dti-1349	85	26	of	of	ADP
dti-1349	85	27	antimicrobial	antimicrobial	ADJ
dti-1349	85	28	agents	agent	NOUN
dti-1349	85	29	.	.	PUNCT
dti-1349	86	1	the	the	DET
dti-1349	86	2	treatment	treatment	NOUN
dti-1349	86	3	becomes	become	VERB
dti-1349	86	4	troublesome	troublesome	ADJ
dti-1349	86	5	in	in	ADP
dti-1349	86	6	the	the	DET
dti-1349	86	7	case	case	NOUN
dti-1349	86	8	of	of	ADP
dti-1349	86	9	the	the	DET
dti-1349	86	10	infections	infection	NOUN
dti-1349	86	11	where	where	SCONJ
dti-1349	86	12	p	p	NOUN
dti-1349	86	13	-	-	PUNCT
dti-1349	86	14	gp	gp	NOUN
dti-1349	86	15	substrates	substrate	NOUN
dti-1349	86	16	are	be	AUX
dti-1349	86	17	the	the	DET
dti-1349	86	18	only	only	ADJ
dti-1349	86	19	choice	choice	NOUN
dti-1349	86	20	.	.	PUNCT
dti-1349	87	1	it	it	PRON
dti-1349	87	2	poses	pose	VERB
dti-1349	87	3	several	several	ADJ
dti-1349	87	4	complications	complication	NOUN
dti-1349	87	5	including	include	VERB
dti-1349	87	6	increased	increase	VERB
dti-1349	87	7	costs	cost	NOUN
dti-1349	87	8	,	,	PUNCT
dti-1349	87	9	prolonged	prolonged	ADJ
dti-1349	87	10	duration	duration	NOUN
dti-1349	87	11	of	of	ADP
dti-1349	87	12	hospital	hospital	NOUN
dti-1349	87	13	stay	stay	NOUN
dti-1349	87	14	,	,	PUNCT
dti-1349	87	15	and	and	CCONJ
dti-1349	87	16	higher	high	ADJ
dti-1349	87	17	morbidity	morbidity	NOUN
dti-1349	87	18	and	and	CCONJ
dti-1349	87	19	mortality	mortality	NOUN
dti-1349	87	20	rates.46–48	rates.46–48	NOUN
dti-1349	87	21	the	the	DET
dti-1349	87	22	use	use	NOUN
dti-1349	87	23	of	of	ADP
dti-1349	87	24	inhibitors	inhibitor	NOUN
dti-1349	87	25	may	may	AUX
dti-1349	87	26	be	be	AUX
dti-1349	87	27	a	a	DET
dti-1349	87	28	good	good	ADJ
dti-1349	87	29	strategy	strategy	NOUN
dti-1349	87	30	to	to	PART
dti-1349	87	31	overcome	overcome	VERB
dti-1349	87	32	transporter	transporter	NOUN
dti-1349	87	33	mediated	mediate	VERB
dti-1349	87	34	bacterial	bacterial	ADJ
dti-1349	87	35	multidrug	multidrug	NOUN
dti-1349	87	36	resistance	resistance	NOUN
dti-1349	87	37	.	.	PUNCT
dti-1349	88	1	they	they	PRON
dti-1349	88	2	can	can	AUX
dti-1349	88	3	be	be	AUX
dti-1349	88	4	used	use	VERB
dti-1349	88	5	in	in	ADP
dti-1349	88	6	conjunction	conjunction	NOUN
dti-1349	88	7	with	with	ADP
dti-1349	88	8	antibiotics	antibiotic	NOUN
dti-1349	88	9	and	and	CCONJ
dti-1349	88	10	can	can	AUX
dti-1349	88	11	extend	extend	VERB
dti-1349	88	12	the	the	DET
dti-1349	88	13	lifetime	lifetime	NOUN
dti-1349	88	14	of	of	ADP
dti-1349	88	15	the	the	DET
dti-1349	88	16	antibiotics	antibiotic	NOUN
dti-1349	88	17	,	,	PUNCT
dti-1349	88	18	improving	improve	VERB
dti-1349	88	19	therapeutic	therapeutic	ADJ
dti-1349	88	20	efficacy	efficacy	NOUN
dti-1349	88	21	.	.	PUNCT
dti-1349	89	1	they	they	PRON
dti-1349	89	2	can	can	AUX
dti-1349	89	3	also	also	ADV
dti-1349	89	4	suppress	suppress	VERB
dti-1349	89	5	the	the	DET
dti-1349	89	6	emergence	emergence	NOUN
dti-1349	89	7	of	of	ADP
dti-1349	89	8	resistant	resistant	ADJ
dti-1349	89	9	variants	variant	NOUN
dti-1349	89	10	that	that	PRON
dti-1349	89	11	may	may	AUX
dti-1349	89	12	arise	arise	VERB
dti-1349	89	13	during	during	ADP
dti-1349	89	14	the	the	DET
dti-1349	89	15	treatment	treatment	NOUN
dti-1349	89	16	.	.	PUNCT
dti-1349	90	1	these	these	DET
dti-1349	90	2	inhibitors	inhibitor	NOUN
dti-1349	90	3	increase	increase	VERB
dti-1349	90	4	bacterial	bacterial	ADJ
dti-1349	90	5	susceptibility	susceptibility	NOUN
dti-1349	90	6	towards	towards	ADP
dti-1349	90	7	antimicrobial	antimicrobial	ADJ
dti-1349	90	8	agents.41,49–51	agents.41,49–51	NOUN
dti-1349	90	9	seral	seral	ADJ
dti-1349	90	10	et	et	NOUN
dti-1349	91	1	al52	al52	PROPN
dti-1349	91	2	examined	examine	VERB
dti-1349	91	3	the	the	DET
dti-1349	91	4	influence	influence	NOUN
dti-1349	91	5	of	of	ADP
dti-1349	91	6	inhibitors	inhibitor	NOUN
dti-1349	91	7	of	of	ADP
dti-1349	91	8	p	p	NOUN
dti-1349	91	9	-	-	PUNCT
dti-1349	91	10	gp	gp	NOUN
dti-1349	91	11	(	(	PUNCT
dti-1349	91	12	verapamil	verapamil	NOUN
dti-1349	91	13	,	,	PUNCT
dti-1349	91	14	cyclosporine	cyclosporine	NOUN
dti-1349	91	15	,	,	PUNCT
dti-1349	91	16	and	and	CCONJ
dti-1349	91	17	gf120918	gf120918	NOUN
dti-1349	91	18	)	)	PUNCT
dti-1349	91	19	on	on	ADP
dti-1349	91	20	the	the	DET
dti-1349	91	21	antimicrobial	antimicrobial	ADJ
dti-1349	91	22	activity	activity	NOUN
dti-1349	91	23	of	of	ADP
dti-1349	91	24	macrolides	macrolide	NOUN
dti-1349	91	25	(	(	PUNCT
dti-1349	91	26	erythromycin	erythromycin	PROPN
dti-1349	91	27	,	,	PUNCT
dti-1349	91	28	clarithromycin	clarithromycin	PROPN
dti-1349	91	29	,	,	PUNCT
dti-1349	91	30	roxithromycin	roxithromycin	NOUN
dti-1349	91	31	,	,	PUNCT
dti-1349	91	32	azithromycin	azithromycin	NOUN
dti-1349	91	33	,	,	PUNCT
dti-1349	91	34	and	and	CCONJ
dti-1349	91	35	telithromycin	telithromycin	PROPN
dti-1349	91	36	)	)	PUNCT
dti-1349	91	37	in	in	ADP
dti-1349	91	38	j774	j774	DET
dti-1349	91	39	murine	murine	ADJ
dti-1349	91	40	macrophages	macrophage	NOUN
dti-1349	91	41	.	.	PUNCT
dti-1349	92	1	the	the	DET
dti-1349	92	2	result	result	NOUN
dti-1349	92	3	showed	show	VERB
dti-1349	92	4	that	that	SCONJ
dti-1349	92	5	p	p	X
dti-1349	92	6	-	-	PUNCT
dti-1349	92	7	gp	gp	NOUN
dti-1349	92	8	enhanced	enhance	VERB
dti-1349	92	9	the	the	DET
dti-1349	92	10	extrusion	extrusion	NOUN
dti-1349	92	11	of	of	ADP
dti-1349	92	12	azithromycin	azithromycin	NOUN
dti-1349	92	13	,	,	PUNCT
dti-1349	92	14	erythromycin	erythromycin	NOUN
dti-1349	92	15	,	,	PUNCT
dti-1349	92	16	telithromycin	telithromycin	PROPN
dti-1349	92	17	,	,	PUNCT
dti-1349	92	18	and	and	CCONJ
dti-1349	92	19	roxithromycin	roxithromycin	PROPN
dti-1349	92	20	,	,	PUNCT
dti-1349	92	21	resulting	result	VERB
dti-1349	92	22	in	in	ADP
dti-1349	92	23	suboptimal	suboptimal	ADJ
dti-1349	92	24	drug	drug	NOUN
dti-1349	92	25	accumulation	accumulation	NOUN
dti-1349	92	26	.	.	PUNCT
dti-1349	93	1	hence	hence	ADV
dti-1349	93	2	,	,	PUNCT
dti-1349	93	3	inhibitors	inhibitor	NOUN
dti-1349	93	4	can	can	AUX
dti-1349	93	5	enhance	enhance	VERB
dti-1349	93	6	their	their	PRON
dti-1349	93	7	accumulations	accumulation	NOUN
dti-1349	93	8	inside	inside	ADP
dti-1349	93	9	the	the	DET
dti-1349	93	10	cells	cell	NOUN
dti-1349	93	11	and	and	CCONJ
dti-1349	93	12	increase	increase	VERB
dti-1349	93	13	antimicrobial	antimicrobial	ADJ
dti-1349	93	14	actions.52	actions.52	ADJ
dti-1349	93	15	leitner	leitner	NOUN
dti-1349	93	16	et	et	NOUN
dti-1349	93	17	al49	al49	PROPN
dti-1349	93	18	investigated	investigate	VERB
dti-1349	93	19	the	the	DET
dti-1349	93	20	potency	potency	NOUN
dti-1349	93	21	of	of	ADP
dti-1349	93	22	tariquidar	tariquidar	NOUN
dti-1349	93	23	,	,	PUNCT
dti-1349	93	24	a	a	DET
dti-1349	93	25	third	third	ADJ
dti-1349	93	26	-	-	PUNCT
dti-1349	93	27	generation	generation	NOUN
dti-1349	93	28	p	p	NOUN
dti-1349	93	29	-	-	PUNCT
dti-1349	93	30	gp	gp	NOUN
dti-1349	93	31	inhibitor	inhibitor	NOUN
dti-1349	93	32	,	,	PUNCT
dti-1349	93	33	for	for	ADP
dti-1349	93	34	overcoming	overcome	VERB
dti-1349	93	35	bacterial	bacterial	ADJ
dti-1349	93	36	resistance	resistance	NOUN
dti-1349	93	37	towards	towards	ADP
dti-1349	93	38	ciprofloxacin	ciprofloxacin	NOUN
dti-1349	93	39	.	.	PUNCT
dti-1349	94	1	activity	activity	NOUN
dti-1349	94	2	of	of	ADP
dti-1349	94	3	tariquidar	tariquidar	PRON
dti-1349	94	4	was	be	AUX
dti-1349	94	5	evaluated	evaluate	VERB
dti-1349	94	6	by	by	ADP
dti-1349	94	7	staphylococcus	staphylococcus	NOUN
dti-1349	94	8	aureus	aureus	NOUN
dti-1349	94	9	strains	strain	VERB
dti-1349	94	10	.	.	PUNCT
dti-1349	95	1	the	the	DET
dti-1349	95	2	addition	addition	NOUN
dti-1349	95	3	of	of	ADP
dti-1349	95	4	tariquidar	tariquidar	PRON
dti-1349	95	5	resulted	result	VERB
dti-1349	95	6	in	in	ADP
dti-1349	95	7	a	a	DET
dti-1349	95	8	10	10	NUM
dti-1349	95	9	-	-	ADJ
dti-1349	95	10	fold	fold	ADJ
dti-1349	95	11	reduction	reduction	NOUN
dti-1349	95	12	in	in	ADP
dti-1349	95	13	the	the	DET
dti-1349	95	14	minimum	minimum	ADJ
dti-1349	95	15	inhibitory	inhibitory	ADJ
dti-1349	95	16	concentration	concentration	NOUN
dti-1349	95	17	(	(	PUNCT
dti-1349	95	18	mic	mic	NOUN
dti-1349	95	19	)	)	PUNCT
dti-1349	95	20	of	of	ADP
dti-1349	95	21	ciprofloxacin	ciprofloxacin	PROPN
dti-1349	95	22	.	.	PUNCT
dti-1349	96	1	the	the	DET
dti-1349	96	2	result	result	NOUN
dti-1349	96	3	suggested	suggest	VERB
dti-1349	96	4	that	that	SCONJ
dti-1349	96	5	tariquidar	tariquidar	PRON
dti-1349	96	6	significantly	significantly	ADV
dti-1349	96	7	increased	increase	VERB
dti-1349	96	8	susceptibility	susceptibility	NOUN
dti-1349	96	9	of	of	ADP
dti-1349	96	10	s.	s.	PROPN
dti-1349	96	11	aureus	aureus	PROPN
dti-1349	96	12	towards	towards	ADP
dti-1349	96	13	ciprofloxacin	ciprofloxacin	PROPN
dti-1349	96	14	.	.	PUNCT
dti-1349	97	1	their	their	PRON
dti-1349	97	2	high	high	ADJ
dti-1349	97	3	activity	activity	NOUN
dti-1349	97	4	can	can	AUX
dti-1349	97	5	be	be	AUX
dti-1349	97	6	very	very	ADV
dti-1349	97	7	promising	promising	ADJ
dti-1349	97	8	for	for	ADP
dti-1349	97	9	applications	application	NOUN
dti-1349	97	10	in	in	ADP
dti-1349	97	11	infectious	infectious	ADJ
dti-1349	97	12	diseases	disease	NOUN
dti-1349	97	13	.	.	PUNCT
dti-1349	98	1	their	their	PRON
dti-1349	98	2	study	study	NOUN
dti-1349	98	3	also	also	ADV
dti-1349	98	4	showed	show	VERB
dti-1349	98	5	the	the	DET
dti-1349	98	6	improved	improved	ADJ
dti-1349	98	7	susceptibility	susceptibility	NOUN
dti-1349	98	8	of	of	ADP
dti-1349	98	9	stenotrophomonas	stenotrophomona	NOUN
dti-1349	98	10	maltophilia	maltophilia	VERB
dti-1349	98	11	towards	towards	ADP
dti-1349	98	12	elacridar.48	elacridar.48	PROPN
dti-1349	98	13	cancer	cancer	NOUN
dti-1349	98	14	chemotherapy	chemotherapy	NOUN
dti-1349	98	15	p	p	X
dti-1349	98	16	-	-	PUNCT
dti-1349	98	17	gp	gp	NOUN
dti-1349	98	18	is	be	AUX
dti-1349	98	19	overexpressed	overexpresse	VERB
dti-1349	98	20	on	on	ADP
dti-1349	98	21	the	the	DET
dti-1349	98	22	surface	surface	NOUN
dti-1349	98	23	of	of	ADP
dti-1349	98	24	cancer	cancer	NOUN
dti-1349	98	25	cells	cell	NOUN
dti-1349	98	26	and	and	CCONJ
dti-1349	98	27	prevents	prevent	VERB
dti-1349	98	28	drug	drug	NOUN
dti-1349	98	29	accumulation	accumulation	NOUN
dti-1349	98	30	inside	inside	ADP
dti-1349	98	31	the	the	DET
dti-1349	98	32	tumor	tumor	NOUN
dti-1349	98	33	,	,	PUNCT
dti-1349	98	34	acting	act	VERB
dti-1349	98	35	as	as	ADP
dti-1349	98	36	the	the	DET
dti-1349	98	37	efflux	efflux	NOUN
dti-1349	98	38	pump	pump	NOUN
dti-1349	98	39	.	.	PUNCT
dti-1349	99	1	it	it	PRON
dti-1349	99	2	extrudes	extrude	VERB
dti-1349	99	3	anticancer	anticancer	NOUN
dti-1349	99	4	drugs	drug	NOUN
dti-1349	99	5	before	before	SCONJ
dti-1349	99	6	they	they	PRON
dti-1349	99	7	can	can	AUX
dti-1349	99	8	reach	reach	VERB
dti-1349	99	9	the	the	DET
dti-1349	99	10	intended	intend	VERB
dti-1349	99	11	target	target	NOUN
dti-1349	99	12	.	.	PUNCT
dti-1349	100	1	further	far	ADV
dti-1349	100	2	,	,	PUNCT
dti-1349	100	3	it	it	PRON
dti-1349	100	4	often	often	ADV
dti-1349	100	5	mediates	mediate	VERB
dti-1349	100	6	the	the	DET
dti-1349	100	7	development	development	NOUN
dti-1349	100	8	of	of	ADP
dti-1349	100	9	resistance	resistance	NOUN
dti-1349	100	10	of	of	ADP
dti-1349	100	11	the	the	DET
dti-1349	100	12	cells	cell	NOUN
dti-1349	100	13	to	to	PART
dti-1349	100	14	anticancer	anticancer	VERB
dti-1349	100	15	drugs	drug	NOUN
dti-1349	100	16	.	.	PUNCT
dti-1349	101	1	therefore	therefore	ADV
dti-1349	101	2	,	,	PUNCT
dti-1349	101	3	the	the	DET
dti-1349	101	4	administered	administer	VERB
dti-1349	101	5	drugs	drug	NOUN
dti-1349	101	6	remain	remain	VERB
dti-1349	101	7	ineffective	ineffective	ADJ
dti-1349	101	8	or	or	CCONJ
dti-1349	101	9	can	can	AUX
dti-1349	101	10	not	not	PART
dti-1349	101	11	bring	bring	VERB
dti-1349	101	12	the	the	DET
dti-1349	101	13	desired	desire	VERB
dti-1349	101	14	output	output	NOUN
dti-1349	101	15	.	.	PUNCT
dti-1349	102	1	several	several	ADJ
dti-1349	102	2	approaches	approach	NOUN
dti-1349	102	3	have	have	AUX
dti-1349	102	4	been	be	AUX
dti-1349	102	5	taken	take	VERB
dti-1349	102	6	to	to	PART
dti-1349	102	7	overcome	overcome	VERB
dti-1349	102	8	p	p	NOUN
dti-1349	102	9	-	-	PUNCT
dti-1349	102	10	gp	gp	NOUN
dti-1349	102	11	mediated	mediate	VERB
dti-1349	102	12	drug	drug	NOUN
dti-1349	102	13	resistance.53,54	resistance.53,54	NOUN
dti-1349	102	14	p	p	NOUN
dti-1349	102	15	-	-	PUNCT
dti-1349	102	16	gp	gp	NOUN
dti-1349	102	17	locates	locate	VERB
dti-1349	102	18	drugs	drug	NOUN
dti-1349	102	19	which	which	PRON
dti-1349	102	20	are	be	AUX
dti-1349	102	21	localized	localize	VERB
dti-1349	102	22	in	in	ADP
dti-1349	102	23	the	the	DET
dti-1349	102	24	plasma	plasma	NOUN
dti-1349	102	25	membrane	membrane	NOUN
dti-1349	102	26	only	only	ADV
dti-1349	102	27	.	.	PUNCT
dti-1349	103	1	concurrent	concurrent	ADJ
dti-1349	103	2	administration	administration	NOUN
dti-1349	103	3	of	of	ADP
dti-1349	103	4	cytotoxic	cytotoxic	ADJ
dti-1349	103	5	drugs	drug	NOUN
dti-1349	103	6	and	and	CCONJ
dti-1349	103	7	inhibiting	inhibit	VERB
dti-1349	103	8	agents	agent	NOUN
dti-1349	103	9	,	,	PUNCT
dti-1349	103	10	like	like	ADP
dti-1349	103	11	verapamil	verapamil	NOUN
dti-1349	103	12	or	or	CCONJ
dti-1349	103	13	cyclosporine	cyclosporine	NOUN
dti-1349	103	14	,	,	PUNCT
dti-1349	103	15	can	can	AUX
dti-1349	103	16	restrain	restrain	VERB
dti-1349	103	17	p	p	NOUN
dti-1349	103	18	-	-	PUNCT
dti-1349	103	19	gp	gp	NOUN
dti-1349	103	20	mediated	mediate	VERB
dti-1349	103	21	extrusion	extrusion	NOUN
dti-1349	103	22	and	and	CCONJ
dti-1349	103	23	facilitate	facilitate	VERB
dti-1349	103	24	the	the	DET
dti-1349	103	25	http://www.la-press.com	http://www.la-press.com	X
dti-1349	103	26	amin	amin	PROPN
dti-1349	103	27	32	32	NUM
dti-1349	103	28	drug	drug	NOUN
dti-1349	103	29	target	target	NOUN
dti-1349	103	30	insights	insight	NOUN
dti-1349	103	31	2013:7	2013:7	NUM
dti-1349	103	32	drug	drug	NOUN
dti-1349	103	33	in	in	ADP
dti-1349	103	34	reaching	reach	VERB
dti-1349	103	35	the	the	DET
dti-1349	103	36	targeted	target	VERB
dti-1349	103	37	area	area	NOUN
dti-1349	103	38	.	.	PUNCT
dti-1349	104	1	thus	thus	ADV
dti-1349	104	2	both	both	CCONJ
dti-1349	104	3	chemotherapeutic	chemotherapeutic	ADJ
dti-1349	104	4	agent	agent	NOUN
dti-1349	104	5	and	and	CCONJ
dti-1349	104	6	inhibiting	inhibit	VERB
dti-1349	104	7	agent	agent	NOUN
dti-1349	104	8	are	be	AUX
dti-1349	104	9	incorporated	incorporate	VERB
dti-1349	104	10	into	into	ADP
dti-1349	104	11	the	the	DET
dti-1349	104	12	carrier	carrier	NOUN
dti-1349	104	13	system	system	NOUN
dti-1349	104	14	to	to	PART
dti-1349	104	15	overcome	overcome	VERB
dti-1349	104	16	the	the	DET
dti-1349	104	17	difficulty	difficulty	NOUN
dti-1349	104	18	associated	associate	VERB
dti-1349	104	19	with	with	ADP
dti-1349	104	20	p	p	PROPN
dti-1349	104	21	-	-	PUNCT
dti-1349	104	22	gp.55,56	gp.55,56	NOUN
dti-1349	104	23	another	another	DET
dti-1349	104	24	strategy	strategy	NOUN
dti-1349	104	25	could	could	AUX
dti-1349	104	26	be	be	AUX
dti-1349	104	27	the	the	DET
dti-1349	104	28	involvement	involvement	NOUN
dti-1349	104	29	of	of	ADP
dti-1349	104	30	anti	anti	ADJ
dti-1349	104	31	-	-	ADJ
dti-1349	104	32	p	p	ADJ
dti-1349	104	33	-	-	PUNCT
dti-1349	104	34	gp	gp	NOUN
dti-1349	104	35	monoclonal	monoclonal	NOUN
dti-1349	104	36	antibody	antibody	NOUN
dti-1349	104	37	in	in	ADP
dti-1349	104	38	refraining	refrain	VERB
dti-1349	104	39	p	p	NOUN
dti-1349	104	40	-	-	PUNCT
dti-1349	104	41	gp	gp	NOUN
dti-1349	104	42	from	from	ADP
dti-1349	104	43	extruding	extruding	NOUN
dti-1349	104	44	drugs	drug	NOUN
dti-1349	104	45	.	.	PUNCT
dti-1349	105	1	in	in	ADP
dti-1349	105	2	this	this	DET
dti-1349	105	3	process	process	NOUN
dti-1349	105	4	,	,	PUNCT
dti-1349	105	5	the	the	DET
dti-1349	105	6	antibody	antibody	NOUN
dti-1349	105	7	is	be	AUX
dti-1349	105	8	conjugated	conjugate	VERB
dti-1349	105	9	to	to	ADP
dti-1349	105	10	the	the	DET
dti-1349	105	11	drug	drug	NOUN
dti-1349	105	12	loaded	load	VERB
dti-1349	105	13	carrier	carrier	NOUN
dti-1349	105	14	system	system	NOUN
dti-1349	105	15	,	,	PUNCT
dti-1349	105	16	which	which	PRON
dti-1349	105	17	can	can	AUX
dti-1349	105	18	sufficiently	sufficiently	ADV
dti-1349	105	19	inhibit	inhibit	VERB
dti-1349	105	20	drug	drug	NOUN
dti-1349	105	21	efflux	efflux	NOUN
dti-1349	105	22	.	.	PUNCT
dti-1349	106	1	vincristine	vincristine	NOUN
dti-1349	106	2	-	-	PUNCT
dti-1349	106	3	loaded	load	VERB
dti-1349	106	4	lipid	lipid	NOUN
dti-1349	106	5	nanoparticles	nanoparticle	NOUN
dti-1349	106	6	conjugated	conjugate	VERB
dti-1349	106	7	to	to	ADP
dti-1349	106	8	an	an	DET
dti-1349	106	9	anti	anti	ADJ
dti-1349	106	10	-	-	ADJ
dti-1349	106	11	p	p	ADJ
dti-1349	106	12	-	-	PUNCT
dti-1349	106	13	gp	gp	NOUN
dti-1349	106	14	monoclonal	monoclonal	NOUN
dti-1349	106	15	antibody	antibody	NOUN
dti-1349	106	16	(	(	PUNCT
dti-1349	106	17	mrk-16	mrk-16	NOUN
dti-1349	106	18	)	)	PUNCT
dti-1349	106	19	,	,	PUNCT
dti-1349	106	20	showed	show	VERB
dti-1349	106	21	greater	great	ADJ
dti-1349	106	22	cytotoxicity	cytotoxicity	NOUN
dti-1349	106	23	in	in	ADP
dti-1349	106	24	resistant	resistant	ADJ
dti-1349	106	25	human	human	ADJ
dti-1349	106	26	myelogenous	myelogenous	ADJ
dti-1349	106	27	leukemia	leukemia	NOUN
dti-1349	106	28	cell	cell	NOUN
dti-1349	106	29	lines	line	NOUN
dti-1349	106	30	than	than	ADP
dti-1349	106	31	non	non	ADJ
dti-1349	106	32	-	-	ADJ
dti-1349	106	33	targeted	targeted	ADJ
dti-1349	106	34	particles.14	particles.14	NOUN
dti-1349	106	35	goda	goda	PROPN
dti-1349	106	36	et	et	PROPN
dti-1349	106	37	al29	al29	PROPN
dti-1349	106	38	reported	report	VERB
dti-1349	106	39	that	that	SCONJ
dti-1349	106	40	combination	combination	NOUN
dti-1349	106	41	therapy	therapy	NOUN
dti-1349	106	42	with	with	ADP
dti-1349	106	43	uic2	uic2	ADJ
dti-1349	106	44	monoclonal	monoclonal	NOUN
dti-1349	106	45	antibody	antibody	NOUN
dti-1349	106	46	and	and	CCONJ
dti-1349	106	47	cyclosporine	cyclosporine	VERB
dti-1349	106	48	a	a	PRON
dti-1349	106	49	,	,	PUNCT
dti-1349	106	50	a	a	DET
dti-1349	106	51	first	first	ADJ
dti-1349	106	52	generation	generation	NOUN
dti-1349	106	53	p	p	NOUN
dti-1349	106	54	-	-	PUNCT
dti-1349	106	55	gp	gp	NOUN
dti-1349	106	56	inhibitor	inhibitor	NOUN
dti-1349	106	57	administered	administer	VERB
dti-1349	106	58	at	at	ADP
dti-1349	106	59	the	the	DET
dti-1349	106	60	dose	dose	NOUN
dti-1349	106	61	ineffective	ineffective	ADJ
dti-1349	106	62	when	when	SCONJ
dti-1349	106	63	applied	apply	VERB
dti-1349	106	64	alone	alone	ADV
dti-1349	106	65	,	,	PUNCT
dti-1349	106	66	dramatically	dramatically	ADV
dti-1349	106	67	increased	increase	VERB
dti-1349	106	68	daunorubicin	daunorubicin	PROPN
dti-1349	106	69	accumulation	accumulation	NOUN
dti-1349	106	70	in	in	ADP
dti-1349	106	71	xenotransplanted	xenotransplante	VERB
dti-1349	106	72	pgp+	pgp+	PROPN
dti-1349	106	73	tumors	tumor	NOUN
dti-1349	106	74	.	.	PUNCT
dti-1349	107	1	it	it	PRON
dti-1349	107	2	established	establish	VERB
dti-1349	107	3	that	that	SCONJ
dti-1349	107	4	combined	combined	ADJ
dti-1349	107	5	application	application	NOUN
dti-1349	107	6	of	of	ADP
dti-1349	107	7	uic2	uic2	ADJ
dti-1349	107	8	antibody	antibody	NOUN
dti-1349	107	9	and	and	CCONJ
dti-1349	107	10	a	a	DET
dti-1349	107	11	class	class	NOUN
dti-1349	107	12	of	of	ADP
dti-1349	107	13	modulators	modulator	NOUN
dti-1349	107	14	,	,	PUNCT
dti-1349	107	15	used	use	VERB
dti-1349	107	16	at	at	ADP
dti-1349	107	17	low	low	ADJ
dti-1349	107	18	concentrations	concentration	NOUN
dti-1349	107	19	,	,	PUNCT
dti-1349	107	20	can	can	AUX
dti-1349	107	21	be	be	AUX
dti-1349	107	22	a	a	DET
dti-1349	107	23	specific	specific	ADJ
dti-1349	107	24	and	and	CCONJ
dti-1349	107	25	effective	effective	ADJ
dti-1349	107	26	way	way	NOUN
dti-1349	107	27	of	of	ADP
dti-1349	107	28	blocking	block	VERB
dti-1349	107	29	p	p	NOUN
dti-1349	107	30	-	-	PUNCT
dti-1349	107	31	gp	gp	NOUN
dti-1349	107	32	function	function	NOUN
dti-1349	107	33	in	in	ADP
dti-1349	107	34	vivo.29	vivo.29	PROPN
dti-1349	107	35	danson	danson	PROPN
dti-1349	107	36	et	et	PROPN
dti-1349	107	37	al57	al57	PROPN
dti-1349	107	38	developed	develop	VERB
dti-1349	107	39	sp1049c	sp1049c	PROPN
dti-1349	107	40	,	,	PUNCT
dti-1349	107	41	a	a	DET
dti-1349	107	42	non	non	ADJ
dti-1349	107	43	-	-	ADJ
dti-1349	107	44	ionic	ionic	ADJ
dti-1349	107	45	block	block	NOUN
dti-1349	107	46	copolymer	copolymer	NOUN
dti-1349	107	47	composed	compose	VERB
dti-1349	107	48	of	of	ADP
dti-1349	107	49	a	a	DET
dti-1349	107	50	hydrophobic	hydrophobic	NOUN
dti-1349	107	51	core	core	NOUN
dti-1349	107	52	and	and	CCONJ
dti-1349	107	53	hydrophilic	hydrophilic	ADJ
dti-1349	107	54	tail	tail	NOUN
dti-1349	107	55	,	,	PUNCT
dti-1349	107	56	which	which	PRON
dti-1349	107	57	contained	contain	VERB
dti-1349	107	58	doxorubicin	doxorubicin	PROPN
dti-1349	107	59	and	and	CCONJ
dti-1349	107	60	was	be	AUX
dti-1349	107	61	able	able	ADJ
dti-1349	107	62	to	to	PART
dti-1349	107	63	circumvent	circumvent	VERB
dti-1349	107	64	p	p	NOUN
dti-1349	107	65	-	-	PUNCT
dti-1349	107	66	gp	gp	NOUN
dti-1349	107	67	mediated	mediate	VERB
dti-1349	107	68	drug	drug	NOUN
dti-1349	107	69	resistance	resistance	NOUN
dti-1349	107	70	in	in	ADP
dti-1349	107	71	a	a	DET
dti-1349	107	72	mouse	mouse	NOUN
dti-1349	107	73	model	model	NOUN
dti-1349	107	74	of	of	ADP
dti-1349	107	75	leukaemia.57,58	leukaemia.57,58	PROPN
dti-1349	107	76	tidefelt	tidefelt	PROPN
dti-1349	107	77	et	et	PROPN
dti-1349	107	78	al59	al59	PROPN
dti-1349	107	79	found	find	VERB
dti-1349	107	80	that	that	SCONJ
dti-1349	107	81	by	by	ADP
dti-1349	107	82	interacting	interact	VERB
dti-1349	107	83	with	with	ADP
dti-1349	107	84	p	p	NOUN
dti-1349	107	85	-	-	PUNCT
dti-1349	107	86	gp	gp	NOUN
dti-1349	107	87	,	,	PUNCT
dti-1349	107	88	valspodar	valspodar	PROPN
dti-1349	107	89	can	can	AUX
dti-1349	107	90	increase	increase	VERB
dti-1349	107	91	the	the	DET
dti-1349	107	92	cellular	cellular	ADJ
dti-1349	107	93	uptake	uptake	NOUN
dti-1349	107	94	of	of	ADP
dti-1349	107	95	daunorubicin	daunorubicin	NOUN
dti-1349	107	96	in	in	ADP
dti-1349	107	97	leukemic	leukemic	ADJ
dti-1349	107	98	blasts	blast	NOUN
dti-1349	107	99	in	in	ADP
dti-1349	107	100	vivo	vivo	NOUN
dti-1349	107	101	.	.	PUNCT
dti-1349	108	1	in	in	ADP
dti-1349	108	2	another	another	DET
dti-1349	108	3	study	study	NOUN
dti-1349	108	4	,	,	PUNCT
dti-1349	108	5	folic	folic	NOUN
dti-1349	108	6	acid	acid	NOUN
dti-1349	108	7	,	,	PUNCT
dti-1349	108	8	attached	attach	VERB
dti-1349	108	9	to	to	ADP
dti-1349	108	10	peg	peg	NOUN
dti-1349	108	11	derivatized	derivatize	VERB
dti-1349	108	12	distearoyl	distearoyl	NOUN
dti-1349	108	13	-	-	PUNCT
dti-1349	108	14	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
dti-1349	108	15	in	in	ADP
dti-1349	108	16	doxorubicin	doxorubicin	PROPN
dti-1349	108	17	loaded	load	VERB
dti-1349	108	18	liposomes	liposome	NOUN
dti-1349	108	19	,	,	PUNCT
dti-1349	108	20	was	be	AUX
dti-1349	108	21	used	use	VERB
dti-1349	108	22	to	to	PART
dti-1349	108	23	target	target	VERB
dti-1349	108	24	folate	folate	NOUN
dti-1349	108	25	receptor	receptor	NOUN
dti-1349	108	26	overexpressing	overexpresse	VERB
dti-1349	108	27	tumor	tumor	NOUN
dti-1349	108	28	cells	cell	NOUN
dti-1349	108	29	.	.	PUNCT
dti-1349	109	1	folate	folate	NOUN
dti-1349	109	2	receptor	receptor	NOUN
dti-1349	109	3	mediated	mediate	VERB
dti-1349	109	4	cell	cell	NOUN
dti-1349	109	5	uptake	uptake	NOUN
dti-1349	109	6	of	of	ADP
dti-1349	109	7	targeted	target	VERB
dti-1349	109	8	liposomal	liposomal	ADJ
dti-1349	109	9	doxorubicin	doxorubicin	PROPN
dti-1349	109	10	into	into	ADP
dti-1349	109	11	a	a	DET
dti-1349	109	12	multidrug	multidrug	NOUN
dti-1349	109	13	resistant	resistant	ADJ
dti-1349	109	14	subline	subline	NOUN
dti-1349	109	15	of	of	ADP
dti-1349	109	16	m109	m109	PROPN
dti-1349	109	17	-	-	PUNCT
dti-1349	109	18	hifr	hifr	NOUN
dti-1349	109	19	cells	cell	NOUN
dti-1349	109	20	(	(	PUNCT
dti-1349	109	21	m109r	m109r	PROPN
dti-1349	109	22	-	-	PUNCT
dti-1349	109	23	hifr	hifr	NOUN
dti-1349	109	24	)	)	PUNCT
dti-1349	109	25	was	be	AUX
dti-1349	109	26	clearly	clearly	ADV
dti-1349	109	27	unaffected	unaffected	ADJ
dti-1349	109	28	by	by	ADP
dti-1349	109	29	p	p	NOUN
dti-1349	109	30	-	-	PUNCT
dti-1349	109	31	gp	gp	NOUN
dti-1349	109	32	mediated	mediate	VERB
dti-1349	109	33	drug	drug	NOUN
dti-1349	109	34	efflux	efflux	NOUN
dti-1349	109	35	,	,	PUNCT
dti-1349	109	36	in	in	ADP
dti-1349	109	37	sharp	sharp	ADJ
dti-1349	109	38	contrast	contrast	NOUN
dti-1349	109	39	to	to	ADP
dti-1349	109	40	uptake	uptake	NOUN
dti-1349	109	41	of	of	ADP
dti-1349	109	42	free	free	ADJ
dti-1349	109	43	doxorubicin.15	doxorubicin.15	NOUN
dti-1349	109	44	conclusion	conclusion	NOUN
dti-1349	109	45	p	p	X
dti-1349	109	46	-	-	PUNCT
dti-1349	109	47	gp	gp	NOUN
dti-1349	109	48	is	be	AUX
dti-1349	109	49	one	one	NUM
dti-1349	109	50	of	of	ADP
dti-1349	109	51	the	the	DET
dti-1349	109	52	main	main	ADJ
dti-1349	109	53	barriers	barrier	NOUN
dti-1349	109	54	for	for	ADP
dti-1349	109	55	delivering	deliver	VERB
dti-1349	109	56	drugs	drug	NOUN
dti-1349	109	57	properly	properly	ADV
dti-1349	109	58	.	.	PUNCT
dti-1349	110	1	a	a	DET
dti-1349	110	2	variety	variety	NOUN
dti-1349	110	3	of	of	ADP
dti-1349	110	4	approaches	approach	NOUN
dti-1349	110	5	are	be	AUX
dti-1349	110	6	being	be	AUX
dti-1349	110	7	tested	test	VERB
dti-1349	110	8	to	to	PART
dti-1349	110	9	develop	develop	VERB
dti-1349	110	10	p	p	NOUN
dti-1349	110	11	-	-	PUNCT
dti-1349	110	12	gp	gp	NOUN
dti-1349	110	13	inhibitors	inhibitor	NOUN
dti-1349	110	14	or	or	CCONJ
dti-1349	110	15	mechanisms	mechanism	NOUN
dti-1349	110	16	to	to	PART
dti-1349	110	17	bypass	bypass	VERB
dti-1349	110	18	it	it	PRON
dti-1349	110	19	.	.	PUNCT
dti-1349	111	1	proper	proper	ADJ
dti-1349	111	2	inhibition	inhibition	NOUN
dti-1349	111	3	will	will	AUX
dti-1349	111	4	allow	allow	VERB
dti-1349	111	5	not	not	PART
dti-1349	111	6	only	only	ADV
dti-1349	111	7	an	an	DET
dti-1349	111	8	increase	increase	NOUN
dti-1349	111	9	in	in	ADP
dti-1349	111	10	cellular	cellular	ADJ
dti-1349	111	11	uptake	uptake	NOUN
dti-1349	111	12	,	,	PUNCT
dti-1349	111	13	transport	transport	NOUN
dti-1349	111	14	,	,	PUNCT
dti-1349	111	15	and	and	CCONJ
dti-1349	111	16	half	half	ADJ
dti-1349	111	17	-	-	PUNCT
dti-1349	111	18	lives	life	NOUN
dti-1349	111	19	of	of	ADP
dti-1349	111	20	drugs	drug	NOUN
dti-1349	111	21	,	,	PUNCT
dti-1349	111	22	but	but	CCONJ
dti-1349	111	23	also	also	ADV
dti-1349	111	24	to	to	PART
dti-1349	111	25	predict	predict	VERB
dti-1349	111	26	their	their	PRON
dti-1349	111	27	pharmacokinetics	pharmacokinetic	NOUN
dti-1349	111	28	accurately	accurately	ADV
dti-1349	111	29	and	and	CCONJ
dti-1349	111	30	fine	fine	ADJ
dti-1349	111	31	tune	tune	NOUN
dti-1349	111	32	them	they	PRON
dti-1349	111	33	for	for	ADP
dti-1349	111	34	targeting	target	VERB
dti-1349	111	35	specific	specific	ADJ
dti-1349	111	36	region	region	NOUN
dti-1349	111	37	.	.	PUNCT
dti-1349	112	1	these	these	DET
dti-1349	112	2	advances	advance	NOUN
dti-1349	112	3	will	will	AUX
dti-1349	112	4	result	result	VERB
dti-1349	112	5	in	in	ADP
dti-1349	112	6	cost	cost	NOUN
dti-1349	112	7	effective	effective	ADJ
dti-1349	112	8	therapy	therapy	NOUN
dti-1349	112	9	by	by	ADP
dti-1349	112	10	saving	save	VERB
dti-1349	112	11	the	the	DET
dti-1349	112	12	additional	additional	ADJ
dti-1349	112	13	amount	amount	NOUN
dti-1349	112	14	of	of	ADP
dti-1349	112	15	drugs	drug	NOUN
dti-1349	112	16	that	that	PRON
dti-1349	112	17	was	be	AUX
dti-1349	112	18	previously	previously	ADV
dti-1349	112	19	wasted	waste	VERB
dti-1349	112	20	by	by	ADP
dti-1349	112	21	p	p	NOUN
dti-1349	112	22	-	-	PUNCT
dti-1349	112	23	gp	gp	NOUN
dti-1349	112	24	transport	transport	NOUN
dti-1349	112	25	.	.	PUNCT
dti-1349	113	1	furthermore	furthermore	ADV
dti-1349	113	2	,	,	PUNCT
dti-1349	113	3	it	it	PRON
dti-1349	113	4	will	will	AUX
dti-1349	113	5	shorten	shorten	VERB
dti-1349	113	6	the	the	DET
dti-1349	113	7	treatment	treatment	NOUN
dti-1349	113	8	time	time	NOUN
dti-1349	113	9	with	with	ADP
dti-1349	113	10	optimal	optimal	ADJ
dti-1349	113	11	drug	drug	NOUN
dti-1349	113	12	delivery	delivery	NOUN
dti-1349	113	13	.	.	PUNCT
dti-1349	114	1	thus	thus	ADV
dti-1349	114	2	it	it	PRON
dti-1349	114	3	can	can	AUX
dti-1349	114	4	bring	bring	VERB
dti-1349	114	5	a	a	DET
dti-1349	114	6	great	great	ADJ
dti-1349	114	7	revolution	revolution	NOUN
dti-1349	114	8	in	in	ADP
dti-1349	114	9	the	the	DET
dti-1349	114	10	field	field	NOUN
dti-1349	114	11	of	of	ADP
dti-1349	114	12	drug	drug	NOUN
dti-1349	114	13	delivery	delivery	NOUN
dti-1349	114	14	.	.	PUNCT
dti-1349	115	1	author	author	NOUN
dti-1349	115	2	contributions	contribution	NOUN
dti-1349	115	3	conceived	conceive	VERB
dti-1349	115	4	and	and	CCONJ
dti-1349	115	5	designed	design	VERB
dti-1349	115	6	the	the	DET
dti-1349	115	7	experiments	experiment	NOUN
dti-1349	115	8	:	:	PUNCT
dti-1349	115	9	mla	mla	PROPN
dti-1349	115	10	.	.	PROPN
dti-1349	115	11	analyzed	analyze	VERB
dti-1349	115	12	the	the	DET
dti-1349	115	13	data	datum	NOUN
dti-1349	115	14	:	:	PUNCT
dti-1349	115	15	mla	mla	PROPN
dti-1349	115	16	.	.	PROPN
dti-1349	116	1	wrote	write	VERB
dti-1349	116	2	the	the	DET
dti-1349	116	3	first	first	ADJ
dti-1349	116	4	draft	draft	NOUN
dti-1349	116	5	of	of	ADP
dti-1349	116	6	the	the	DET
dti-1349	116	7	manuscript	manuscript	NOUN
dti-1349	116	8	:	:	PUNCT
dti-1349	116	9	mla	mla	PROPN
dti-1349	116	10	.	.	PROPN
dti-1349	117	1	contributed	contribute	VERB
dti-1349	117	2	to	to	ADP
dti-1349	117	3	the	the	DET
dti-1349	117	4	writing	writing	NOUN
dti-1349	117	5	of	of	ADP
dti-1349	117	6	the	the	DET
dti-1349	117	7	manuscript	manuscript	NOUN
dti-1349	117	8	:	:	PUNCT
dti-1349	117	9	mla	mla	PROPN
dti-1349	117	10	.	.	PUNCT
dti-1349	118	1	agree	agree	VERB
dti-1349	118	2	with	with	ADP
dti-1349	118	3	manuscript	manuscript	NOUN
dti-1349	118	4	results	result	NOUN
dti-1349	118	5	and	and	CCONJ
dti-1349	118	6	conclusions	conclusion	NOUN
dti-1349	118	7	:	:	PUNCT
dti-1349	118	8	mla	mla	NOUN
dti-1349	118	9	.	.	PUNCT
dti-1349	119	1	jointly	jointly	ADV
dti-1349	119	2	developed	develop	VERB
dti-1349	119	3	the	the	DET
dti-1349	119	4	structure	structure	NOUN
dti-1349	119	5	and	and	CCONJ
dti-1349	119	6	arguments	argument	NOUN
dti-1349	119	7	for	for	ADP
dti-1349	119	8	the	the	DET
dti-1349	119	9	paper	paper	NOUN
dti-1349	119	10	:	:	PUNCT
dti-1349	119	11	mla	mla	NOUN
dti-1349	119	12	.	.	PUNCT
dti-1349	120	1	made	make	VERB
dti-1349	120	2	critical	critical	ADJ
dti-1349	120	3	revisions	revision	NOUN
dti-1349	120	4	and	and	CCONJ
dti-1349	120	5	approved	approve	VERB
dti-1349	120	6	final	final	ADJ
dti-1349	120	7	version	version	NOUN
dti-1349	120	8	:	:	PUNCT
dti-1349	120	9	mla	mla	PROPN
dti-1349	120	10	.	.	PUNCT
dti-1349	121	1	author	author	NOUN
dti-1349	121	2	reviewed	review	VERB
dti-1349	121	3	and	and	CCONJ
dti-1349	121	4	approved	approve	VERB
dti-1349	121	5	of	of	ADP
dti-1349	121	6	the	the	DET
dti-1349	121	7	final	final	ADJ
dti-1349	121	8	manuscript	manuscript	NOUN
dti-1349	121	9	.	.	PUNCT
dti-1349	122	1	funding	funding	PROPN
dti-1349	122	2	author(s	author(s	PROPN
dti-1349	122	3	)	)	PUNCT
dti-1349	122	4	disclose	disclose	VERB
dti-1349	122	5	no	no	DET
dti-1349	122	6	funding	funding	NOUN
dti-1349	122	7	sources	source	NOUN
dti-1349	122	8	.	.	PUNCT
dti-1349	123	1	competing	compete	VERB
dti-1349	123	2	interests	interest	NOUN
dti-1349	123	3	author(s	author(s	NOUN
dti-1349	123	4	)	)	PUNCT
dti-1349	123	5	disclose	disclose	VERB
dti-1349	123	6	no	no	DET
dti-1349	123	7	potential	potential	ADJ
dti-1349	123	8	conflicts	conflict	NOUN
dti-1349	123	9	of	of	ADP
dti-1349	123	10	interest	interest	NOUN
dti-1349	123	11	.	.	PUNCT
dti-1349	124	1	disclosures	disclosure	NOUN
dti-1349	124	2	and	and	CCONJ
dti-1349	124	3	ethics	ethic	NOUN
dti-1349	124	4	as	as	ADP
dti-1349	124	5	a	a	DET
dti-1349	124	6	requirement	requirement	NOUN
dti-1349	124	7	of	of	ADP
dti-1349	124	8	publication	publication	NOUN
dti-1349	124	9	the	the	DET
dti-1349	124	10	author	author	NOUN
dti-1349	124	11	has	have	AUX
dti-1349	124	12	provided	provide	VERB
dti-1349	124	13	signed	sign	VERB
dti-1349	124	14	confirmation	confirmation	NOUN
dti-1349	124	15	of	of	ADP
dti-1349	124	16	compliance	compliance	NOUN
dti-1349	124	17	with	with	ADP
dti-1349	124	18	ethical	ethical	ADJ
dti-1349	124	19	and	and	CCONJ
dti-1349	124	20	legal	legal	ADJ
dti-1349	124	21	obligations	obligation	NOUN
dti-1349	124	22	including	include	VERB
dti-1349	124	23	but	but	CCONJ
dti-1349	124	24	not	not	PART
dti-1349	124	25	limited	limit	VERB
dti-1349	124	26	to	to	ADP
dti-1349	124	27	compliance	compliance	NOUN
dti-1349	124	28	with	with	ADP
dti-1349	124	29	icmje	icmje	NOUN
dti-1349	124	30	authorship	authorship	NOUN
dti-1349	124	31	and	and	CCONJ
dti-1349	124	32	competing	compete	VERB
dti-1349	124	33	interests	interest	NOUN
dti-1349	124	34	guidelines	guideline	NOUN
dti-1349	124	35	,	,	PUNCT
dti-1349	124	36	that	that	SCONJ
dti-1349	124	37	the	the	DET
dti-1349	124	38	article	article	NOUN
dti-1349	124	39	is	be	AUX
dti-1349	124	40	neither	neither	CCONJ
dti-1349	124	41	under	under	ADP
dti-1349	124	42	consideration	consideration	NOUN
dti-1349	124	43	for	for	ADP
dti-1349	124	44	publication	publication	NOUN
dti-1349	124	45	nor	nor	CCONJ
dti-1349	124	46	published	publish	VERB
dti-1349	124	47	elsewhere	elsewhere	ADV
dti-1349	124	48	,	,	PUNCT
dti-1349	124	49	of	of	ADP
dti-1349	124	50	their	their	PRON
dti-1349	124	51	compliance	compliance	NOUN
dti-1349	124	52	with	with	ADP
dti-1349	124	53	legal	legal	ADJ
dti-1349	124	54	and	and	CCONJ
dti-1349	124	55	ethical	ethical	ADJ
dti-1349	124	56	guidelines	guideline	NOUN
dti-1349	124	57	concerning	concern	VERB
dti-1349	124	58	human	human	ADJ
dti-1349	124	59	and	and	CCONJ
dti-1349	124	60	animal	animal	NOUN
dti-1349	124	61	research	research	NOUN
dti-1349	124	62	participants	participant	NOUN
dti-1349	124	63	(	(	PUNCT
dti-1349	124	64	if	if	SCONJ
dti-1349	124	65	applicable	applicable	ADJ
dti-1349	124	66	)	)	PUNCT
dti-1349	124	67	,	,	PUNCT
dti-1349	124	68	and	and	CCONJ
dti-1349	124	69	that	that	DET
dti-1349	124	70	permission	permission	NOUN
dti-1349	124	71	has	have	AUX
dti-1349	124	72	been	be	AUX
dti-1349	124	73	obtained	obtain	VERB
dti-1349	124	74	for	for	ADP
dti-1349	124	75	reproduction	reproduction	NOUN
dti-1349	124	76	of	of	ADP
dti-1349	124	77	any	any	DET
dti-1349	124	78	copyrighted	copyright	VERB
dti-1349	124	79	material	material	NOUN
dti-1349	124	80	.	.	PUNCT
dti-1349	125	1	this	this	DET
dti-1349	125	2	article	article	NOUN
dti-1349	125	3	was	be	AUX
dti-1349	125	4	subject	subject	ADJ
dti-1349	125	5	to	to	ADP
dti-1349	125	6	blind	blind	ADJ
dti-1349	125	7	,	,	PUNCT
dti-1349	125	8	independent	independent	ADJ
dti-1349	125	9	,	,	PUNCT
dti-1349	125	10	expert	expert	ADJ
dti-1349	125	11	peer	peer	NOUN
dti-1349	125	12	review	review	NOUN
dti-1349	125	13	.	.	PUNCT
dti-1349	126	1	the	the	DET
dti-1349	126	2	reviewers	reviewer	NOUN
dti-1349	126	3	reported	report	VERB
dti-1349	126	4	no	no	DET
dti-1349	126	5	competing	compete	VERB
dti-1349	126	6	interests	interest	NOUN
dti-1349	126	7	.	.	PUNCT
dti-1349	127	1	references	reference	NOUN
dti-1349	127	2	1	1	NUM
dti-1349	127	3	.	.	PUNCT
dti-1349	127	4	srivalli	srivalli	PROPN
dti-1349	127	5	kmr	kmr	PROPN
dti-1349	127	6	,	,	PUNCT
dti-1349	127	7	lakshmi	lakshmi	PROPN
dti-1349	127	8	pk	pk	PROPN
dti-1349	127	9	.	.	PROPN
dti-1349	127	10	overview	overview	NOUN
dti-1349	127	11	of	of	ADP
dti-1349	127	12	p	p	NOUN
dti-1349	127	13	-	-	PUNCT
dti-1349	127	14	glycoprotein	glycoprotein	NOUN
dti-1349	127	15	inhibitors	inhibitor	NOUN
dti-1349	127	16	:	:	PUNCT
dti-1349	127	17	a	a	DET
dti-1349	127	18	rational	rational	ADJ
dti-1349	127	19	outlook	outlook	NOUN
dti-1349	127	20	.	.	PUNCT
dti-1349	128	1	braz	braz	PROPN
dti-1349	128	2	j	j	PROPN
dti-1349	128	3	pharm	pharm	PROPN
dti-1349	128	4	sci	sci	PROPN
dti-1349	128	5	.	.	PUNCT
dti-1349	129	1	2012;48(3):353–67	2012;48(3):353–67	NUM
dti-1349	129	2	.	.	NOUN
dti-1349	129	3	2	2	NUM
dti-1349	129	4	.	.	X
dti-1349	129	5	sharom	sharom	NOUN
dti-1349	129	6	fj	fj	PROPN
dti-1349	129	7	.	.	PUNCT
dti-1349	130	1	the	the	DET
dti-1349	130	2	p	p	ADJ
dti-1349	130	3	-	-	PUNCT
dti-1349	130	4	glycoprotein	glycoprotein	NOUN
dti-1349	130	5	multidrug	multidrug	NOUN
dti-1349	130	6	transporter	transporter	NOUN
dti-1349	130	7	.	.	PUNCT
dti-1349	131	1	essays	essays	PROPN
dti-1349	131	2	biochem	biochem	PROPN
dti-1349	131	3	.	.	PUNCT
dti-1349	132	1	2011;50(1):161–78	2011;50(1):161–78	NUM
dti-1349	132	2	.	.	PUNCT
dti-1349	132	3	3	3	X
dti-1349	132	4	.	.	X
dti-1349	132	5	edwards	edwards	PROPN
dti-1349	132	6	je	je	PROPN
dti-1349	132	7	,	,	PUNCT
dti-1349	132	8	alcorn	alcorn	PROPN
dti-1349	132	9	j	j	PROPN
dti-1349	132	10	,	,	PUNCT
dti-1349	132	11	savolainen	savolainen	PROPN
dti-1349	132	12	j	j	PROPN
dti-1349	132	13	,	,	PUNCT
dti-1349	132	14	anderson	anderson	PROPN
dti-1349	132	15	bd	bd	PROPN
dti-1349	132	16	,	,	PUNCT
dti-1349	132	17	mcnamara	mcnamara	PROPN
dti-1349	132	18	pj	pj	PROPN
dti-1349	132	19	.	.	PUNCT
dti-1349	132	20	role	role	NOUN
dti-1349	132	21	of	of	ADP
dti-1349	132	22	p	p	NOUN
dti-1349	132	23	-	-	PUNCT
dti-1349	132	24	glycoprotein	glycoprotein	NOUN
dti-1349	132	25	in	in	ADP
dti-1349	132	26	distribution	distribution	NOUN
dti-1349	132	27	of	of	ADP
dti-1349	132	28	nelfinavir	nelfinavir	PRON
dti-1349	132	29	across	across	ADP
dti-1349	132	30	the	the	DET
dti-1349	132	31	blood	blood	NOUN
dti-1349	132	32	-	-	PUNCT
dti-1349	132	33	mammary	mammary	ADJ
dti-1349	132	34	tissue	tissue	NOUN
dti-1349	132	35	barrier	barrier	NOUN
dti-1349	132	36	and	and	CCONJ
dti-1349	132	37	blood	blood	NOUN
dti-1349	132	38	-	-	PUNCT
dti-1349	132	39	brain	brain	NOUN
dti-1349	132	40	barrier	barrier	NOUN
dti-1349	132	41	.	.	PUNCT
dti-1349	133	1	antimicrob	antimicrob	PROPN
dti-1349	133	2	agents	agents	PROPN
dti-1349	133	3	chemother	chemother	PROPN
dti-1349	133	4	.	.	PUNCT
dti-1349	134	1	2005;49(4	2005;49(4	NUM
dti-1349	134	2	):	):	PUNCT
dti-1349	134	3	1626–8	1626–8	NUM
dti-1349	134	4	.	.	NOUN
dti-1349	134	5	4	4	NUM
dti-1349	134	6	.	.	NUM
dti-1349	134	7	melaine	melaine	PROPN
dti-1349	134	8	n	n	SYM
dti-1349	134	9	,	,	PUNCT
dti-1349	134	10	liénard	liénard	PROPN
dti-1349	134	11	mo	mo	PROPN
dti-1349	134	12	,	,	PUNCT
dti-1349	134	13	dorval	dorval	PROPN
dti-1349	135	1	i	i	PRON
dti-1349	135	2	,	,	PUNCT
dti-1349	135	3	le	le	PROPN
dti-1349	135	4	goascogne	goascogne	PROPN
dti-1349	135	5	c	c	PROPN
dti-1349	135	6	,	,	PUNCT
dti-1349	135	7	lejeune	lejeune	PROPN
dti-1349	135	8	h	h	PROPN
dti-1349	135	9	,	,	PUNCT
dti-1349	135	10	jégou	jégou	PROPN
dti-1349	135	11	b.	b.	PROPN
dti-1349	135	12	multidrug	multidrug	VERB
dti-1349	135	13	resistance	resistance	NOUN
dti-1349	135	14	genes	gene	NOUN
dti-1349	135	15	and	and	CCONJ
dti-1349	135	16	p	p	NOUN
dti-1349	135	17	-	-	PUNCT
dti-1349	135	18	glycoprotein	glycoprotein	NOUN
dti-1349	135	19	in	in	ADP
dti-1349	135	20	the	the	DET
dti-1349	135	21	testis	testis	NOUN
dti-1349	135	22	of	of	ADP
dti-1349	135	23	the	the	DET
dti-1349	135	24	rat	rat	NOUN
dti-1349	135	25	,	,	PUNCT
dti-1349	135	26	mouse	mouse	NOUN
dti-1349	135	27	,	,	PUNCT
dti-1349	135	28	guinea	guinea	NOUN
dti-1349	135	29	pig	pig	NOUN
dti-1349	135	30	,	,	PUNCT
dti-1349	135	31	and	and	CCONJ
dti-1349	135	32	human	human	NOUN
dti-1349	135	33	.	.	PUNCT
dti-1349	136	1	biol	biol	PROPN
dti-1349	136	2	reprod	reprod	PROPN
dti-1349	136	3	.	.	PUNCT
dti-1349	137	1	2002;67(6):1699–707	2002;67(6):1699–707	NUM
dti-1349	137	2	.	.	X
dti-1349	138	1	5	5	NUM
dti-1349	138	2	.	.	X
dti-1349	138	3	beaulieu	beaulieu	NOUN
dti-1349	138	4	e	e	PROPN
dti-1349	138	5	,	,	PUNCT
dti-1349	138	6	demeule	demeule	NOUN
dti-1349	138	7	m	m	PROPN
dti-1349	138	8	,	,	PUNCT
dti-1349	138	9	ghitescu	ghitescu	PROPN
dti-1349	138	10	l	l	PROPN
dti-1349	138	11	,	,	PUNCT
dti-1349	138	12	beliveau	beliveau	PROPN
dti-1349	138	13	r.	r.	PROPN
dti-1349	138	14	p	p	VERB
dti-1349	138	15	-	-	PUNCT
dti-1349	138	16	glycoprotein	glycoprotein	NOUN
dti-1349	138	17	is	be	AUX
dti-1349	138	18	strongly	strongly	ADV
dti-1349	138	19	expressed	express	VERB
dti-1349	138	20	in	in	ADP
dti-1349	138	21	the	the	DET
dti-1349	138	22	luminal	luminal	ADJ
dti-1349	138	23	membranes	membrane	NOUN
dti-1349	138	24	of	of	ADP
dti-1349	138	25	the	the	DET
dti-1349	138	26	endothelium	endothelium	NOUN
dti-1349	138	27	of	of	ADP
dti-1349	138	28	blood	blood	NOUN
dti-1349	138	29	vessels	vessel	NOUN
dti-1349	138	30	in	in	ADP
dti-1349	138	31	the	the	DET
dti-1349	138	32	brain	brain	NOUN
dti-1349	138	33	.	.	PUNCT
dti-1349	139	1	biochem	biochem	PROPN
dti-1349	139	2	j.	j.	PROPN
dti-1349	139	3	1997;326(pt	1997;326(pt	PROPN
dti-1349	139	4	2):539–44	2):539–44	PROPN
dti-1349	139	5	.	.	PROPN
dti-1349	140	1	6	6	NUM
dti-1349	140	2	.	.	PUNCT
dti-1349	140	3	ma	ma	PROPN
dti-1349	140	4	jd	jd	PROPN
dti-1349	140	5	,	,	PUNCT
dti-1349	140	6	tsunoda	tsunoda	PROPN
dti-1349	140	7	sm	sm	PROPN
dti-1349	140	8	,	,	PUNCT
dti-1349	140	9	bertino	bertino	PROPN
dti-1349	140	10	js	js	PROPN
dti-1349	140	11	jr	jr	PROPN
dti-1349	140	12	,	,	PUNCT
dti-1349	140	13	trivedi	trivedi	PROPN
dti-1349	140	14	m	m	PROPN
dti-1349	140	15	,	,	PUNCT
dti-1349	140	16	beale	beale	PROPN
dti-1349	140	17	kk	kk	PROPN
dti-1349	140	18	,	,	PUNCT
dti-1349	140	19	nafziger	nafziger	ADJ
dti-1349	140	20	an	an	PRON
dti-1349	140	21	.	.	PUNCT
dti-1349	140	22	evaluation	evaluation	NOUN
dti-1349	140	23	of	of	ADP
dti-1349	140	24	in	in	ADP
dti-1349	140	25	vivo	vivo	ADJ
dti-1349	140	26	p	p	NOUN
dti-1349	140	27	-	-	PUNCT
dti-1349	140	28	glycoprotein	glycoprotein	NOUN
dti-1349	140	29	phenotyping	phenotyping	NOUN
dti-1349	140	30	probes	probe	NOUN
dti-1349	140	31	:	:	PUNCT
dti-1349	140	32	a	a	DET
dti-1349	140	33	need	need	NOUN
dti-1349	140	34	for	for	ADP
dti-1349	140	35	validation	validation	NOUN
dti-1349	140	36	.	.	PUNCT
dti-1349	141	1	clin	clin	PROPN
dti-1349	141	2	pharmacokinet	pharmacokinet	PROPN
dti-1349	141	3	.	.	PUNCT
dti-1349	142	1	2010;49(4):223–37	2010;49(4):223–37	NUM
dti-1349	142	2	.	.	PUNCT
dti-1349	142	3	http://www.la-press.com	http://www.la-press.com	X
dti-1349	143	1	p	p	X
dti-1349	143	2	-	-	PUNCT
dti-1349	143	3	glycoprotein	glycoprotein	NOUN
dti-1349	143	4	inhibition	inhibition	NOUN
dti-1349	143	5	for	for	ADP
dti-1349	143	6	optimal	optimal	ADJ
dti-1349	143	7	drug	drug	NOUN
dti-1349	143	8	delivery	delivery	NOUN
dti-1349	143	9	drug	drug	NOUN
dti-1349	143	10	target	target	NOUN
dti-1349	143	11	insights	insight	NOUN
dti-1349	143	12	2013:7	2013:7	NUM
dti-1349	143	13	33	33	NUM
dti-1349	143	14	7	7	NUM
dti-1349	143	15	.	.	PUNCT
dti-1349	144	1	fortuna	fortuna	PROPN
dti-1349	144	2	a	a	PRON
dti-1349	144	3	,	,	PUNCT
dti-1349	144	4	alves	alves	PROPN
dti-1349	144	5	g	g	PROPN
dti-1349	144	6	,	,	PUNCT
dti-1349	144	7	falcao	falcao	PROPN
dti-1349	144	8	a.	a.	PROPN
dti-1349	144	9	in	in	ADP
dti-1349	144	10	vitro	vitro	X
dti-1349	144	11	and	and	CCONJ
dti-1349	144	12	in	in	ADP
dti-1349	144	13	vivo	vivo	ADJ
dti-1349	144	14	relevance	relevance	NOUN
dti-1349	144	15	of	of	ADP
dti-1349	144	16	the	the	DET
dti-1349	144	17	p	p	NOUN
dti-1349	144	18	-	-	PUNCT
dti-1349	144	19	glycoprotein	glycoprotein	NOUN
dti-1349	144	20	probe	probe	NOUN
dti-1349	144	21	substrates	substrate	NOUN
dti-1349	144	22	in	in	ADP
dti-1349	144	23	drug	drug	NOUN
dti-1349	144	24	discovery	discovery	NOUN
dti-1349	144	25	and	and	CCONJ
dti-1349	144	26	development	development	NOUN
dti-1349	144	27	:	:	PUNCT
dti-1349	144	28	focus	focus	VERB
dti-1349	144	29	on	on	ADP
dti-1349	144	30	rhodamine	rhodamine	NOUN
dti-1349	144	31	123	123	NUM
dti-1349	144	32	,	,	PUNCT
dti-1349	144	33	digoxin	digoxin	NOUN
dti-1349	144	34	and	and	CCONJ
dti-1349	144	35	talinolol	talinolol	NOUN
dti-1349	144	36	.	.	PUNCT
dti-1349	145	1	j	j	PROPN
dti-1349	145	2	bioequiv	bioequiv	PROPN
dti-1349	145	3	availab	availab	PROPN
dti-1349	145	4	.	.	PUNCT
dti-1349	146	1	2011	2011	NUM
dti-1349	146	2	:	:	PUNCT
dti-1349	146	3	s2	s2	NOUN
dti-1349	146	4	.	.	PUNCT
dti-1349	146	5	8	8	NUM
dti-1349	146	6	.	.	PUNCT
dti-1349	147	1	ruetz	ruetz	PROPN
dti-1349	147	2	s	s	PART
dti-1349	147	3	,	,	PUNCT
dti-1349	147	4	gros	gros	X
dti-1349	147	5	p.	p.	NOUN
dti-1349	147	6	phosphatidylcholine	phosphatidylcholine	NOUN
dti-1349	147	7	translocase	translocase	NOUN
dti-1349	147	8	:	:	PUNCT
dti-1349	147	9	a	a	DET
dti-1349	147	10	physiological	physiological	ADJ
dti-1349	147	11	role	role	NOUN
dti-1349	147	12	for	for	ADP
dti-1349	147	13	the	the	DET
dti-1349	147	14	mdr2	mdr2	PROPN
dti-1349	147	15	gene	gene	NOUN
dti-1349	147	16	.	.	PUNCT
dti-1349	148	1	cell	cell	NOUN
dti-1349	148	2	.	.	PUNCT
dti-1349	149	1	1994;77(7):1071–81	1994;77(7):1071–81	NUM
dti-1349	149	2	.	.	PUNCT
dti-1349	150	1	9	9	X
dti-1349	150	2	.	.	X
dti-1349	150	3	lin	lin	PROPN
dti-1349	150	4	jh	jh	PROPN
dti-1349	150	5	,	,	PUNCT
dti-1349	150	6	yamazaki	yamazaki	PROPN
dti-1349	150	7	m.	m.	NOUN
dti-1349	150	8	role	role	NOUN
dti-1349	150	9	of	of	ADP
dti-1349	150	10	p	p	NOUN
dti-1349	150	11	-	-	PUNCT
dti-1349	150	12	glycoprotein	glycoprotein	NOUN
dti-1349	150	13	in	in	ADP
dti-1349	150	14	parmacokinetics	parmacokinetic	NOUN
dti-1349	150	15	:	:	PUNCT
dti-1349	150	16	clinical	clinical	ADJ
dti-1349	150	17	implications	implication	NOUN
dti-1349	150	18	.	.	PUNCT
dti-1349	151	1	clin	clin	PROPN
dti-1349	151	2	pharmacokinet	pharmacokinet	PROPN
dti-1349	151	3	.	.	PUNCT
dti-1349	152	1	2003;42(1):59–98	2003;42(1):59–98	X
dti-1349	152	2	.	.	PUNCT
dti-1349	153	1	10	10	NUM
dti-1349	153	2	.	.	PUNCT
dti-1349	154	1	varma	varma	PROPN
dti-1349	154	2	mvs	mvs	PROPN
dti-1349	154	3	,	,	PUNCT
dti-1349	154	4	ashokraj	ashokraj	ADJ
dti-1349	154	5	y	y	PROPN
dti-1349	154	6	,	,	PUNCT
dti-1349	154	7	dey	dey	PROPN
dti-1349	154	8	cs	cs	PROPN
dti-1349	154	9	,	,	PUNCT
dti-1349	154	10	panchagnula	panchagnula	PROPN
dti-1349	154	11	r.	r.	PROPN
dti-1349	154	12	p	p	NOUN
dti-1349	154	13	-	-	PUNCT
dti-1349	154	14	glycoprotein	glycoprotein	NOUN
dti-1349	154	15	inhibitors	inhibitor	NOUN
dti-1349	154	16	and	and	CCONJ
dti-1349	154	17	their	their	PRON
dti-1349	154	18	screening	screening	NOUN
dti-1349	154	19	:	:	PUNCT
dti-1349	154	20	a	a	DET
dti-1349	154	21	perspective	perspective	NOUN
dti-1349	154	22	from	from	ADP
dti-1349	154	23	bioavailability	bioavailability	NOUN
dti-1349	154	24	enhancement	enhancement	NOUN
dti-1349	154	25	.	.	PUNCT
dti-1349	155	1	pharmacol	pharmacol	NOUN
dti-1349	155	2	res	re	NOUN
dti-1349	155	3	.	.	PUNCT
dti-1349	156	1	2003;48(4):347–59	2003;48(4):347–59	NUM
dti-1349	156	2	.	.	PUNCT
dti-1349	156	3	11	11	NUM
dti-1349	156	4	.	.	PUNCT
dti-1349	157	1	sharom	sharom	NOUN
dti-1349	157	2	fj	fj	PROPN
dti-1349	157	3	,	,	PUNCT
dti-1349	157	4	liu	liu	PROPN
dti-1349	157	5	r	r	PROPN
dti-1349	157	6	,	,	PUNCT
dti-1349	157	7	qu	qu	PROPN
dti-1349	157	8	q	q	PROPN
dti-1349	157	9	,	,	PUNCT
dti-1349	157	10	romsicki	romsicki	ADJ
dti-1349	157	11	y.	y.	PROPN
dti-1349	157	12	exploring	explore	VERB
dti-1349	157	13	the	the	DET
dti-1349	157	14	structure	structure	NOUN
dti-1349	157	15	and	and	CCONJ
dti-1349	157	16	function	function	NOUN
dti-1349	157	17	of	of	ADP
dti-1349	157	18	the	the	DET
dti-1349	157	19	pglycoprotein	pglycoprotein	ADJ
dti-1349	157	20	multidrug	multidrug	NOUN
dti-1349	157	21	transporter	transporter	NOUN
dti-1349	157	22	using	use	VERB
dti-1349	157	23	fluorescence	fluorescence	ADJ
dti-1349	157	24	spectroscopic	spectroscopic	ADJ
dti-1349	157	25	tools	tool	NOUN
dti-1349	157	26	.	.	PUNCT
dti-1349	158	1	seminars	seminar	NOUN
dti-1349	158	2	cell	cell	PROPN
dti-1349	158	3	dev	dev	PROPN
dti-1349	158	4	biol	biol	NOUN
dti-1349	158	5	.	.	PUNCT
dti-1349	159	1	2001;12(3):257–65	2001;12(3):257–65	NUM
dti-1349	159	2	.	.	PUNCT
dti-1349	160	1	12	12	NUM
dti-1349	160	2	.	.	PUNCT
dti-1349	161	1	martins	martin	VERB
dti-1349	161	2	a	a	PRON
dti-1349	161	3	,	,	PUNCT
dti-1349	161	4	vasas	vasa	NOUN
dti-1349	161	5	a	a	NOUN
dti-1349	161	6	,	,	PUNCT
dti-1349	161	7	schelz	schelz	NOUN
dti-1349	161	8	z	z	PROPN
dti-1349	161	9	,	,	PUNCT
dti-1349	161	10	et	et	PROPN
dti-1349	161	11	al	al	PROPN
dti-1349	161	12	.	.	PUNCT
dti-1349	162	1	constituents	constituent	NOUN
dti-1349	162	2	of	of	ADP
dti-1349	162	3	carpobrotus	carpobrotus	ADJ
dti-1349	162	4	edulis	eduli	NOUN
dti-1349	162	5	inhibit	inhibit	VERB
dti-1349	162	6	p	p	NOUN
dti-1349	162	7	-	-	PUNCT
dti-1349	162	8	glycoprotein	glycoprotein	NOUN
dti-1349	162	9	of	of	ADP
dti-1349	162	10	mdr1	mdr1	PROPN
dti-1349	162	11	-	-	PUNCT
dti-1349	162	12	transfected	transfecte	VERB
dti-1349	162	13	mouse	mouse	NOUN
dti-1349	162	14	lymphoma	lymphoma	NOUN
dti-1349	162	15	cells	cell	NOUN
dti-1349	162	16	.	.	PUNCT
dti-1349	163	1	anticancer	anticancer	NOUN
dti-1349	163	2	res	re	NOUN
dti-1349	163	3	.	.	PUNCT
dti-1349	164	1	2010;30(3):829–35	2010;30(3):829–35	NUM
dti-1349	164	2	.	.	NOUN
dti-1349	164	3	13	13	NUM
dti-1349	164	4	.	.	PUNCT
dti-1349	165	1	bansal	bansal	PROPN
dti-1349	165	2	t	t	PROPN
dti-1349	165	3	,	,	PUNCT
dti-1349	165	4	jaggi	jaggi	PROPN
dti-1349	165	5	m	m	PROPN
dti-1349	165	6	,	,	PUNCT
dti-1349	165	7	khar	khar	PROPN
dti-1349	165	8	rk	rk	PROPN
dti-1349	165	9	,	,	PUNCT
dti-1349	165	10	talegaonkar	talegaonkar	PROPN
dti-1349	165	11	s.	s.	PROPN
dti-1349	165	12	emerging	emerge	VERB
dti-1349	165	13	significance	significance	NOUN
dti-1349	165	14	of	of	ADP
dti-1349	165	15	flavonoids	flavonoid	NOUN
dti-1349	165	16	as	as	ADP
dti-1349	165	17	p	p	NOUN
dti-1349	165	18	-	-	PUNCT
dti-1349	165	19	glycoprotein	glycoprotein	ADJ
dti-1349	165	20	inhibitors	inhibitor	NOUN
dti-1349	165	21	in	in	ADP
dti-1349	165	22	cancer	cancer	NOUN
dti-1349	165	23	chemotherapy	chemotherapy	NOUN
dti-1349	165	24	.	.	PUNCT
dti-1349	166	1	j	j	PROPN
dti-1349	166	2	pharm	pharm	PROPN
dti-1349	166	3	pharm	pharm	PROPN
dti-1349	166	4	sci	sci	PROPN
dti-1349	166	5	.	.	PUNCT
dti-1349	167	1	2009;12(1):46–78	2009;12(1):46–78	X
dti-1349	167	2	.	.	NOUN
dti-1349	167	3	14	14	NUM
dti-1349	167	4	.	.	PUNCT
dti-1349	168	1	matsuo	matsuo	PROPN
dti-1349	168	2	h	h	PROPN
dti-1349	168	3	,	,	PUNCT
dti-1349	168	4	wakasugi	wakasugi	VERB
dti-1349	168	5	m	m	PROPN
dti-1349	168	6	,	,	PUNCT
dti-1349	168	7	takanaga	takanaga	NOUN
dti-1349	168	8	h	h	NOUN
dti-1349	168	9	,	,	PUNCT
dti-1349	168	10	et	et	PROPN
dti-1349	168	11	al	al	PROPN
dti-1349	168	12	.	.	PROPN
dti-1349	168	13	possibility	possibility	NOUN
dti-1349	168	14	of	of	ADP
dti-1349	168	15	the	the	DET
dti-1349	168	16	reversal	reversal	NOUN
dti-1349	168	17	of	of	ADP
dti-1349	168	18	multidrug	multidrug	NOUN
dti-1349	168	19	resistance	resistance	NOUN
dti-1349	168	20	and	and	CCONJ
dti-1349	168	21	the	the	DET
dti-1349	168	22	avoidance	avoidance	NOUN
dti-1349	168	23	of	of	ADP
dti-1349	168	24	side	side	NOUN
dti-1349	168	25	effects	effect	NOUN
dti-1349	168	26	by	by	ADP
dti-1349	168	27	liposomes	liposome	NOUN
dti-1349	168	28	modified	modify	VERB
dti-1349	168	29	with	with	ADP
dti-1349	168	30	mrk-16	mrk-16	PROPN
dti-1349	168	31	,	,	PUNCT
dti-1349	168	32	a	a	DET
dti-1349	168	33	monoclonal	monoclonal	NOUN
dti-1349	168	34	antibody	antibody	NOUN
dti-1349	168	35	to	to	ADP
dti-1349	168	36	p	p	NOUN
dti-1349	168	37	-	-	PUNCT
dti-1349	168	38	glycoprotein	glycoprotein	NOUN
dti-1349	168	39	.	.	PUNCT
dti-1349	169	1	j	j	PROPN
dti-1349	169	2	control	control	PROPN
dti-1349	169	3	release	release	PROPN
dti-1349	169	4	.	.	PUNCT
dti-1349	170	1	2001;77(1–2):77–86	2001;77(1–2):77–86	NUM
dti-1349	170	2	.	.	NOUN
dti-1349	170	3	15	15	NUM
dti-1349	170	4	.	.	PUNCT
dti-1349	171	1	goren	goren	PROPN
dti-1349	171	2	d	d	PROPN
dti-1349	171	3	,	,	PUNCT
dti-1349	171	4	horowitz	horowitz	PROPN
dti-1349	171	5	at	at	ADP
dti-1349	171	6	,	,	PUNCT
dti-1349	171	7	tzemach	tzemach	NOUN
dti-1349	171	8	d	d	NOUN
dti-1349	171	9	,	,	PUNCT
dti-1349	171	10	tarshish	tarshish	VERB
dti-1349	171	11	m	m	PRON
dti-1349	171	12	,	,	PUNCT
dti-1349	171	13	zalipsky	zalipsky	PROPN
dti-1349	171	14	s	s	PART
dti-1349	171	15	,	,	PUNCT
dti-1349	171	16	gabizon	gabizon	PROPN
dti-1349	171	17	a.	a.	PROPN
dti-1349	171	18	nuclear	nuclear	PROPN
dti-1349	171	19	delivery	delivery	NOUN
dti-1349	171	20	of	of	ADP
dti-1349	171	21	doxorubicin	doxorubicin	PROPN
dti-1349	171	22	via	via	ADP
dti-1349	171	23	folate	folate	NOUN
dti-1349	171	24	-	-	PUNCT
dti-1349	171	25	targeted	target	VERB
dti-1349	171	26	liposomes	liposome	NOUN
dti-1349	171	27	with	with	ADP
dti-1349	171	28	bypass	bypass	NOUN
dti-1349	171	29	of	of	ADP
dti-1349	171	30	multidrug	multidrug	NOUN
dti-1349	171	31	-	-	PUNCT
dti-1349	171	32	resistance	resistance	NOUN
dti-1349	171	33	efflux	efflux	NOUN
dti-1349	171	34	pump	pump	NOUN
dti-1349	171	35	.	.	PUNCT
dti-1349	172	1	clin	clin	PROPN
dti-1349	172	2	cancer	cancer	NOUN
dti-1349	172	3	res	re	NOUN
dti-1349	172	4	.	.	PUNCT
dti-1349	173	1	2000;6(5	2000;6(5	NUM
dti-1349	173	2	):	):	PUNCT
dti-1349	174	1	1949–57	1949–57	NUM
dti-1349	174	2	.	.	PUNCT
dti-1349	175	1	16	16	NUM
dti-1349	175	2	.	.	PUNCT
dti-1349	176	1	mazel	mazel	PROPN
dti-1349	176	2	m	m	PROPN
dti-1349	176	3	,	,	PUNCT
dti-1349	176	4	clair	clair	PROPN
dti-1349	176	5	p	p	NOUN
dti-1349	176	6	,	,	PUNCT
dti-1349	176	7	rousselle	rousselle	NOUN
dti-1349	176	8	c	c	NOUN
dti-1349	176	9	,	,	PUNCT
dti-1349	176	10	et	et	PROPN
dti-1349	176	11	al	al	PROPN
dti-1349	176	12	.	.	PROPN
dti-1349	176	13	doxorubicin	doxorubicin	PROPN
dti-1349	176	14	—	—	PUNCT
dti-1349	176	15	peptide	peptide	NOUN
dti-1349	176	16	conjugates	conjugate	NOUN
dti-1349	176	17	overcome	overcome	VERB
dti-1349	176	18	multidrug	multidrug	NOUN
dti-1349	176	19	resistance	resistance	NOUN
dti-1349	176	20	.	.	PUNCT
dti-1349	177	1	anticancer	anticancer	NOUN
dti-1349	177	2	drugs	drug	NOUN
dti-1349	177	3	.	.	PUNCT
dti-1349	178	1	2001;12(2):107–16	2001;12(2):107–16	X
dti-1349	178	2	.	.	NOUN
dti-1349	179	1	17	17	NUM
dti-1349	179	2	.	.	PUNCT
dti-1349	180	1	shapiro	shapiro	PROPN
dti-1349	180	2	ab	ab	PROPN
dti-1349	180	3	,	,	PUNCT
dti-1349	180	4	ling	ling	PROPN
dti-1349	180	5	v.	v.	ADP
dti-1349	180	6	effect	effect	NOUN
dti-1349	180	7	of	of	ADP
dti-1349	180	8	quercetin	quercetin	NOUN
dti-1349	180	9	on	on	ADP
dti-1349	180	10	hoechst	hoechst	ADJ
dti-1349	180	11	33342	33342	NUM
dti-1349	180	12	transport	transport	NOUN
dti-1349	180	13	by	by	ADP
dti-1349	180	14	purified	purified	ADJ
dti-1349	180	15	and	and	CCONJ
dti-1349	180	16	reconstituted	reconstitute	VERB
dti-1349	180	17	p	p	NOUN
dti-1349	180	18	-	-	PUNCT
dti-1349	180	19	glycoprotein	glycoprotein	NOUN
dti-1349	180	20	.	.	PUNCT
dti-1349	181	1	biochem	biochem	PROPN
dti-1349	181	2	pharmacol	pharmacol	PROPN
dti-1349	181	3	.	.	PUNCT
dti-1349	182	1	1997;53(4	1997;53(4	NUM
dti-1349	182	2	):	):	PUNCT
dti-1349	182	3	587–96	587–96	NUM
dti-1349	182	4	.	.	PROPN
dti-1349	182	5	18	18	NUM
dti-1349	182	6	.	.	PUNCT
dti-1349	182	7	drori	drori	PROPN
dti-1349	182	8	s	s	PROPN
dti-1349	182	9	,	,	PUNCT
dti-1349	182	10	eytan	eytan	PROPN
dti-1349	182	11	gd	gd	NOUN
dti-1349	182	12	,	,	PUNCT
dti-1349	182	13	assaraf	assaraf	NOUN
dti-1349	182	14	yg	yg	PROPN
dti-1349	182	15	.	.	PROPN
dti-1349	182	16	potentiation	potentiation	NOUN
dti-1349	182	17	of	of	ADP
dti-1349	182	18	anticancer	anticancer	NOUN
dti-1349	182	19	drug	drug	NOUN
dti-1349	182	20	cytotoxicity	cytotoxicity	NOUN
dti-1349	182	21	by	by	ADP
dti-1349	182	22	multidrug	multidrug	NOUN
dti-1349	182	23	-	-	PUNCT
dti-1349	182	24	resistance	resistance	NOUN
dti-1349	182	25	chemosensitizers	chemosensitizer	NOUN
dti-1349	182	26	involves	involve	VERB
dti-1349	182	27	alterations	alteration	NOUN
dti-1349	182	28	in	in	ADP
dti-1349	182	29	membrane	membrane	NOUN
dti-1349	182	30	fluidity	fluidity	NOUN
dti-1349	182	31	leading	lead	VERB
dti-1349	182	32	to	to	ADP
dti-1349	182	33	increased	increase	VERB
dti-1349	182	34	membrane	membrane	NOUN
dti-1349	182	35	permeability	permeability	NOUN
dti-1349	182	36	.	.	PUNCT
dti-1349	183	1	eur	eur	PROPN
dti-1349	183	2	j	j	PROPN
dti-1349	183	3	biochem	biochem	PROPN
dti-1349	183	4	.	.	PUNCT
dti-1349	184	1	1995;228(3):1020–9	1995;228(3):1020–9	X
dti-1349	184	2	.	.	PROPN
dti-1349	185	1	19	19	NUM
dti-1349	185	2	.	.	PUNCT
dti-1349	185	3	robert	robert	PROPN
dti-1349	185	4	j	j	PROPN
dti-1349	185	5	,	,	PUNCT
dti-1349	185	6	jarry	jarry	PROPN
dti-1349	185	7	c.	c.	PROPN
dti-1349	185	8	multidrug	multidrug	PROPN
dti-1349	185	9	resistance	resistance	NOUN
dti-1349	185	10	reversal	reversal	NOUN
dti-1349	185	11	agents	agent	NOUN
dti-1349	185	12	.	.	PUNCT
dti-1349	186	1	j	j	PROPN
dti-1349	186	2	med	med	PROPN
dti-1349	186	3	chem	chem	NOUN
dti-1349	186	4	.	.	PUNCT
dti-1349	187	1	2003;46(23):4805–17	2003;46(23):4805–17	NUM
dti-1349	187	2	.	.	X
dti-1349	188	1	20	20	NUM
dti-1349	188	2	.	.	PUNCT
dti-1349	189	1	lomovskaya	lomovskaya	PROPN
dti-1349	189	2	o	o	PROPN
dti-1349	189	3	,	,	PUNCT
dti-1349	189	4	bostian	bostian	PROPN
dti-1349	189	5	ka	ka	PROPN
dti-1349	189	6	.	.	PROPN
dti-1349	189	7	practical	practical	ADJ
dti-1349	189	8	applications	application	NOUN
dti-1349	189	9	and	and	CCONJ
dti-1349	189	10	feasibility	feasibility	NOUN
dti-1349	189	11	of	of	ADP
dti-1349	189	12	efflux	efflux	NOUN
dti-1349	189	13	pump	pump	NOUN
dti-1349	189	14	inhibitors	inhibitor	NOUN
dti-1349	189	15	in	in	ADP
dti-1349	189	16	the	the	DET
dti-1349	189	17	clinic	clinic	NOUN
dti-1349	189	18	—	—	PUNCT
dti-1349	189	19	a	a	DET
dti-1349	189	20	vision	vision	NOUN
dti-1349	189	21	for	for	ADP
dti-1349	189	22	applied	applied	ADJ
dti-1349	189	23	use	use	NOUN
dti-1349	189	24	.	.	PUNCT
dti-1349	190	1	biochem	biochem	PROPN
dti-1349	190	2	pharmacol	pharmacol	PROPN
dti-1349	190	3	.	.	PUNCT
dti-1349	191	1	2006;71(7):910–8	2006;71(7):910–8	NUM
dti-1349	191	2	.	.	PUNCT
dti-1349	192	1	21	21	NUM
dti-1349	192	2	.	.	PUNCT
dti-1349	193	1	lomovskaya	lomovskaya	PROPN
dti-1349	193	2	o	o	PROPN
dti-1349	193	3	,	,	PUNCT
dti-1349	193	4	zgurskaya	zgurskaya	PROPN
dti-1349	193	5	hi	hi	INTJ
dti-1349	193	6	,	,	PUNCT
dti-1349	193	7	totrov	totrov	PROPN
dti-1349	193	8	m	m	PROPN
dti-1349	193	9	,	,	PUNCT
dti-1349	193	10	watkins	watkin	VERB
dti-1349	193	11	wj	wj	PROPN
dti-1349	193	12	.	.	PUNCT
dti-1349	194	1	waltzing	waltz	VERB
dti-1349	194	2	transporters	transporter	NOUN
dti-1349	194	3	and	and	CCONJ
dti-1349	194	4	‘	'	PUNCT
dti-1349	194	5	the	the	DET
dti-1349	194	6	dance	dance	NOUN
dti-1349	194	7	macabre	macabre	NOUN
dti-1349	194	8	’	'	PUNCT
dti-1349	194	9	between	between	ADP
dti-1349	194	10	humans	human	NOUN
dti-1349	194	11	and	and	CCONJ
dti-1349	194	12	bacteria	bacteria	NOUN
dti-1349	194	13	.	.	PUNCT
dti-1349	195	1	nat	nat	PROPN
dti-1349	195	2	rev	rev	VERB
dti-1349	195	3	drug	drug	NOUN
dti-1349	195	4	discov	discov	NOUN
dti-1349	195	5	.	.	PUNCT
dti-1349	196	1	2007;6(1):56–65	2007;6(1):56–65	NUM
dti-1349	196	2	.	.	PUNCT
dti-1349	197	1	22	22	NUM
dti-1349	197	2	.	.	PUNCT
dti-1349	198	1	kuppens	kuppen	NOUN
dti-1349	198	2	ie	ie	X
dti-1349	198	3	,	,	PUNCT
dti-1349	198	4	witteveen	witteveen	X
dti-1349	198	5	eo	eo	PROPN
dti-1349	198	6	,	,	PUNCT
dti-1349	198	7	jewell	jewell	PROPN
dti-1349	198	8	rc	rc	PROPN
dti-1349	198	9	,	,	PUNCT
dti-1349	198	10	et	et	PROPN
dti-1349	198	11	al	al	PROPN
dti-1349	198	12	.	.	PUNCT
dti-1349	199	1	a	a	DET
dti-1349	199	2	phase	phase	NOUN
dti-1349	199	3	i	i	PRON
dti-1349	199	4	,	,	PUNCT
dti-1349	199	5	randomized	randomize	VERB
dti-1349	199	6	,	,	PUNCT
dti-1349	199	7	open	open	ADJ
dti-1349	199	8	-	-	PUNCT
dti-1349	199	9	label	label	NOUN
dti-1349	199	10	,	,	PUNCT
dti-1349	199	11	parallel	parallel	NOUN
dti-1349	199	12	-	-	PUNCT
dti-1349	199	13	cohort	cohort	NOUN
dti-1349	199	14	,	,	PUNCT
dti-1349	199	15	dose	dose	NOUN
dti-1349	199	16	-	-	PUNCT
dti-1349	199	17	finding	find	VERB
dti-1349	199	18	study	study	NOUN
dti-1349	199	19	of	of	ADP
dti-1349	199	20	elacridar	elacridar	PROPN
dti-1349	199	21	(	(	PUNCT
dti-1349	199	22	gf120918	gf120918	PROPN
dti-1349	199	23	)	)	PUNCT
dti-1349	199	24	and	and	CCONJ
dti-1349	199	25	oral	oral	ADJ
dti-1349	199	26	topotecan	topotecan	NOUN
dti-1349	199	27	in	in	ADP
dti-1349	199	28	cancer	cancer	NOUN
dti-1349	199	29	patients	patient	NOUN
dti-1349	199	30	.	.	PUNCT
dti-1349	200	1	clin	clin	PROPN
dti-1349	200	2	cancer	cancer	NOUN
dti-1349	200	3	res	re	NOUN
dti-1349	200	4	.	.	PUNCT
dti-1349	201	1	2007;13(11	2007;13(11	NUM
dti-1349	201	2	):	):	PUNCT
dti-1349	201	3	3276–85	3276–85	NUM
dti-1349	201	4	.	.	PUNCT
dti-1349	202	1	23	23	NUM
dti-1349	202	2	.	.	PUNCT
dti-1349	203	1	pusztai	pusztai	PROPN
dti-1349	203	2	l	l	PROPN
dti-1349	203	3	,	,	PUNCT
dti-1349	203	4	wagner	wagner	PROPN
dti-1349	203	5	p	p	PROPN
dti-1349	203	6	,	,	PUNCT
dti-1349	203	7	ibrahim	ibrahim	PROPN
dti-1349	203	8	n	n	CCONJ
dti-1349	203	9	,	,	PUNCT
dti-1349	203	10	et	et	PROPN
dti-1349	203	11	al	al	PROPN
dti-1349	203	12	.	.	PROPN
dti-1349	203	13	phase	phase	PROPN
dti-1349	203	14	ii	ii	PROPN
dti-1349	203	15	study	study	NOUN
dti-1349	203	16	of	of	ADP
dti-1349	203	17	tariquidar	tariquidar	PROPN
dti-1349	203	18	,	,	PUNCT
dti-1349	203	19	a	a	DET
dti-1349	203	20	selective	selective	ADJ
dti-1349	203	21	p	p	NOUN
dti-1349	203	22	-	-	PUNCT
dti-1349	203	23	glycoprotein	glycoprotein	NOUN
dti-1349	203	24	inhibitor	inhibitor	NOUN
dti-1349	203	25	,	,	PUNCT
dti-1349	203	26	in	in	ADP
dti-1349	203	27	patients	patient	NOUN
dti-1349	203	28	with	with	ADP
dti-1349	203	29	chemotherapy	chemotherapy	NOUN
dti-1349	203	30	-	-	ADJ
dti-1349	203	31	resistant	resistant	ADJ
dti-1349	203	32	,	,	PUNCT
dti-1349	203	33	advanced	advanced	ADJ
dti-1349	203	34	breast	breast	NOUN
dti-1349	203	35	carcinoma	carcinoma	NOUN
dti-1349	203	36	.	.	PUNCT
dti-1349	204	1	cancer	cancer	NOUN
dti-1349	204	2	.	.	PUNCT
dti-1349	205	1	2005;104(4):682–91	2005;104(4):682–91	NUM
dti-1349	205	2	.	.	X
dti-1349	205	3	24	24	NUM
dti-1349	205	4	.	.	PUNCT
dti-1349	205	5	malingré	malingré	PROPN
dti-1349	205	6	mm	mm	PROPN
dti-1349	205	7	,	,	PUNCT
dti-1349	205	8	beijnen	beijnen	PROPN
dti-1349	205	9	jh	jh	PROPN
dti-1349	205	10	,	,	PUNCT
dti-1349	205	11	rosing	rose	VERB
dti-1349	205	12	h	h	NOUN
dti-1349	205	13	,	,	PUNCT
dti-1349	205	14	et	et	PROPN
dti-1349	205	15	al	al	PROPN
dti-1349	205	16	.	.	PUNCT
dti-1349	206	1	co	co	PROPN
dti-1349	206	2	-	-	NOUN
dti-1349	206	3	administration	administration	NOUN
dti-1349	206	4	of	of	ADP
dti-1349	206	5	gf120918	gf120918	NOUN
dti-1349	206	6	significantly	significantly	ADV
dti-1349	206	7	increases	increase	VERB
dti-1349	206	8	the	the	DET
dti-1349	206	9	systemic	systemic	ADJ
dti-1349	206	10	exposure	exposure	NOUN
dti-1349	206	11	to	to	ADP
dti-1349	206	12	oral	oral	ADJ
dti-1349	206	13	paclitaxel	paclitaxel	NOUN
dti-1349	206	14	in	in	ADP
dti-1349	206	15	cancer	cancer	NOUN
dti-1349	206	16	patients	patient	NOUN
dti-1349	206	17	.	.	PUNCT
dti-1349	207	1	br	br	PROPN
dti-1349	207	2	j	j	PROPN
dti-1349	207	3	cancer	cancer	NOUN
dti-1349	207	4	.	.	PUNCT
dti-1349	208	1	2001;84(1):42–7	2001;84(1):42–7	ADJ
dti-1349	208	2	.	.	PROPN
dti-1349	209	1	25	25	NUM
dti-1349	209	2	.	.	PUNCT
dti-1349	210	1	thomas	thomas	PROPN
dti-1349	210	2	h	h	PROPN
dti-1349	210	3	,	,	PUNCT
dti-1349	210	4	coley	coley	PROPN
dti-1349	210	5	hm	hm	INTJ
dti-1349	210	6	.	.	PUNCT
dti-1349	211	1	overcoming	overcome	VERB
dti-1349	211	2	multidrug	multidrug	NOUN
dti-1349	211	3	resistance	resistance	NOUN
dti-1349	211	4	in	in	ADP
dti-1349	211	5	cancer	cancer	NOUN
dti-1349	211	6	:	:	PUNCT
dti-1349	211	7	an	an	DET
dti-1349	211	8	update	update	NOUN
dti-1349	211	9	on	on	ADP
dti-1349	211	10	the	the	DET
dti-1349	211	11	clinical	clinical	ADJ
dti-1349	211	12	strategy	strategy	NOUN
dti-1349	211	13	of	of	ADP
dti-1349	211	14	inhibiting	inhibit	VERB
dti-1349	211	15	p	p	NOUN
dti-1349	211	16	-	-	PUNCT
dti-1349	211	17	glycoprotein	glycoprotein	NOUN
dti-1349	211	18	.	.	PUNCT
dti-1349	212	1	cancer	cancer	NOUN
dti-1349	212	2	control	control	NOUN
dti-1349	212	3	.	.	PUNCT
dti-1349	213	1	2003;10(2):159–65	2003;10(2):159–65	NUM
dti-1349	213	2	.	.	PUNCT
dti-1349	214	1	26	26	NUM
dti-1349	214	2	.	.	PUNCT
dti-1349	215	1	krishna	krishna	PROPN
dti-1349	215	2	r	r	PROPN
dti-1349	215	3	,	,	PUNCT
dti-1349	215	4	mayer	mayer	PROPN
dti-1349	215	5	ld	ld	PROPN
dti-1349	215	6	.	.	PROPN
dti-1349	215	7	multidrug	multidrug	VERB
dti-1349	215	8	resistance	resistance	NOUN
dti-1349	215	9	(	(	PUNCT
dti-1349	215	10	mdr	mdr	PROPN
dti-1349	215	11	)	)	PUNCT
dti-1349	215	12	in	in	ADP
dti-1349	215	13	cancer	cancer	NOUN
dti-1349	215	14	.	.	PUNCT
dti-1349	216	1	mechanisms	mechanism	NOUN
dti-1349	216	2	,	,	PUNCT
dti-1349	216	3	reversal	reversal	NOUN
dti-1349	216	4	using	use	VERB
dti-1349	216	5	modulators	modulator	NOUN
dti-1349	216	6	of	of	ADP
dti-1349	216	7	mdr	mdr	PROPN
dti-1349	216	8	and	and	CCONJ
dti-1349	216	9	the	the	DET
dti-1349	216	10	role	role	NOUN
dti-1349	216	11	of	of	ADP
dti-1349	216	12	mdr	mdr	NOUN
dti-1349	216	13	modulators	modulator	NOUN
dti-1349	216	14	in	in	ADP
dti-1349	216	15	influencing	influence	VERB
dti-1349	216	16	the	the	DET
dti-1349	216	17	pharmacokinetics	pharmacokinetic	NOUN
dti-1349	216	18	of	of	ADP
dti-1349	216	19	anticancer	anticancer	NOUN
dti-1349	216	20	drugs	drug	NOUN
dti-1349	216	21	.	.	PUNCT
dti-1349	217	1	eur	eur	PROPN
dti-1349	217	2	j	j	PROPN
dti-1349	217	3	pharm	pharm	PROPN
dti-1349	217	4	sci	sci	PROPN
dti-1349	217	5	.	.	PUNCT
dti-1349	218	1	2000;11(4):265–83	2000;11(4):265–83	NUM
dti-1349	218	2	.	.	PUNCT
dti-1349	218	3	27	27	NUM
dti-1349	218	4	.	.	PUNCT
dti-1349	219	1	newman	newman	PROPN
dti-1349	219	2	mj	mj	PROPN
dti-1349	219	3	,	,	PUNCT
dti-1349	219	4	rodarte	rodarte	PROPN
dti-1349	219	5	jc	jc	PROPN
dti-1349	219	6	,	,	PUNCT
dti-1349	219	7	benbatoul	benbatoul	PROPN
dti-1349	219	8	kd	kd	PROPN
dti-1349	219	9	,	,	PUNCT
dti-1349	219	10	et	et	PROPN
dti-1349	219	11	al	al	PROPN
dti-1349	219	12	.	.	PROPN
dti-1349	219	13	discovery	discovery	PROPN
dti-1349	219	14	and	and	CCONJ
dti-1349	219	15	characterization	characterization	NOUN
dti-1349	219	16	of	of	ADP
dti-1349	219	17	oc144–093	oc144–093	NUM
dti-1349	219	18	,	,	PUNCT
dti-1349	219	19	a	a	DET
dti-1349	219	20	novel	novel	ADJ
dti-1349	219	21	inhibitor	inhibitor	NOUN
dti-1349	219	22	of	of	ADP
dti-1349	219	23	p	p	NOUN
dti-1349	219	24	-	-	PUNCT
dti-1349	219	25	glycoprotein	glycoprotein	NOUN
dti-1349	219	26	-	-	PUNCT
dti-1349	219	27	mediated	mediate	VERB
dti-1349	219	28	multidrug	multidrug	NOUN
dti-1349	219	29	resistance	resistance	NOUN
dti-1349	219	30	.	.	PUNCT
dti-1349	220	1	cancer	cancer	NOUN
dti-1349	220	2	res	re	NOUN
dti-1349	220	3	.	.	PUNCT
dti-1349	221	1	2000;60(11):2964–72	2000;60(11):2964–72	NUM
dti-1349	221	2	.	.	X
dti-1349	222	1	28	28	NUM
dti-1349	222	2	.	.	PUNCT
dti-1349	223	1	nokihara	nokihara	PROPN
dti-1349	223	2	h	h	PROPN
dti-1349	223	3	,	,	PUNCT
dti-1349	223	4	yano	yano	PROPN
dti-1349	223	5	s	s	PROPN
dti-1349	223	6	,	,	PUNCT
dti-1349	223	7	sone	sone	NOUN
dti-1349	223	8	s.	s.	PROPN
dti-1349	223	9	overcoming	overcome	VERB
dti-1349	223	10	of	of	ADP
dti-1349	223	11	multidrug	multidrug	NOUN
dti-1349	223	12	resistance	resistance	NOUN
dti-1349	223	13	by	by	ADP
dti-1349	223	14	antip	antip	NOUN
dti-1349	223	15	-	-	PUNCT
dti-1349	223	16	glycoprotein	glycoprotein	NOUN
dti-1349	223	17	monoclonal	monoclonal	NOUN
dti-1349	223	18	antibody	antibody	NOUN
dti-1349	223	19	.	.	PUNCT
dti-1349	224	1	nippon	nippon	PROPN
dti-1349	224	2	rinsho	rinsho	PROPN
dti-1349	224	3	.	.	PUNCT
dti-1349	225	1	1997;55(5):1128–34	1997;55(5):1128–34	NUM
dti-1349	225	2	.	.	PUNCT
dti-1349	226	1	japanese	japanese	PROPN
dti-1349	226	2	.	.	PUNCT
dti-1349	227	1	29	29	NUM
dti-1349	227	2	.	.	PUNCT
dti-1349	228	1	goda	goda	PROPN
dti-1349	228	2	k	k	PROPN
dti-1349	228	3	,	,	PUNCT
dti-1349	228	4	fenyvesi	fenyvesi	PROPN
dti-1349	228	5	f	f	PROPN
dti-1349	228	6	,	,	PUNCT
dti-1349	228	7	bacsó	bacsó	VERB
dti-1349	228	8	z	z	NOUN
dti-1349	228	9	,	,	PUNCT
dti-1349	228	10	et	et	PROPN
dti-1349	228	11	al	al	PROPN
dti-1349	228	12	.	.	PUNCT
dti-1349	229	1	complete	complete	ADJ
dti-1349	229	2	inhibition	inhibition	NOUN
dti-1349	229	3	of	of	ADP
dti-1349	229	4	p	p	NOUN
dti-1349	229	5	-	-	PUNCT
dti-1349	229	6	glycoprotein	glycoprotein	NOUN
dti-1349	229	7	by	by	ADP
dti-1349	229	8	simultaneous	simultaneous	ADJ
dti-1349	229	9	treatment	treatment	NOUN
dti-1349	229	10	with	with	ADP
dti-1349	229	11	a	a	DET
dti-1349	229	12	distinct	distinct	ADJ
dti-1349	229	13	class	class	NOUN
dti-1349	229	14	of	of	ADP
dti-1349	229	15	modulators	modulator	NOUN
dti-1349	229	16	and	and	CCONJ
dti-1349	229	17	the	the	DET
dti-1349	229	18	uic2	uic2	ADJ
dti-1349	229	19	monoclonal	monoclonal	NOUN
dti-1349	229	20	antibody	antibody	NOUN
dti-1349	229	21	.	.	PUNCT
dti-1349	230	1	j	j	PROPN
dti-1349	230	2	pharmacol	pharmacol	PROPN
dti-1349	230	3	exp	exp	NOUN
dti-1349	230	4	ther	ther	ADV
dti-1349	230	5	.	.	PUNCT
dti-1349	231	1	2007;320(1):81–8	2007;320(1):81–8	NUM
dti-1349	231	2	.	.	NOUN
dti-1349	231	3	30	30	NUM
dti-1349	231	4	.	.	PUNCT
dti-1349	232	1	woo	woo	PROPN
dti-1349	232	2	js	js	PROPN
dti-1349	232	3	,	,	PUNCT
dti-1349	232	4	lee	lee	PROPN
dti-1349	232	5	ch	ch	PROPN
dti-1349	232	6	,	,	PUNCT
dti-1349	232	7	shim	shim	NOUN
dti-1349	232	8	ck	ck	PROPN
dti-1349	232	9	,	,	PUNCT
dti-1349	232	10	hwang	hwang	PROPN
dti-1349	232	11	sj	sj	PROPN
dti-1349	232	12	.	.	PUNCT
dti-1349	232	13	enhanced	enhance	VERB
dti-1349	232	14	oral	oral	ADJ
dti-1349	232	15	bioavailability	bioavailability	NOUN
dti-1349	232	16	of	of	ADP
dti-1349	232	17	paclitaxel	paclitaxel	PROPN
dti-1349	232	18	by	by	ADP
dti-1349	232	19	coadministration	coadministration	NOUN
dti-1349	232	20	of	of	ADP
dti-1349	232	21	the	the	DET
dti-1349	232	22	p	p	NOUN
dti-1349	232	23	-	-	PUNCT
dti-1349	232	24	glycoprotein	glycoprotein	NOUN
dti-1349	232	25	inhibitor	inhibitor	NOUN
dti-1349	232	26	kr30031	kr30031	NOUN
dti-1349	232	27	.	.	PUNCT
dti-1349	233	1	pharm	pharm	NOUN
dti-1349	233	2	res	re	NOUN
dti-1349	233	3	.	.	PUNCT
dti-1349	234	1	2003;20(1):24–30	2003;20(1):24–30	X
dti-1349	234	2	.	.	PROPN
dti-1349	235	1	31	31	NUM
dti-1349	235	2	.	.	PUNCT
dti-1349	236	1	banerjee	banerjee	PROPN
dti-1349	236	2	sk	sk	PROPN
dti-1349	236	3	,	,	PUNCT
dti-1349	236	4	jagannath	jagannath	NOUN
dti-1349	236	5	c	c	PROPN
dti-1349	236	6	,	,	PUNCT
dti-1349	236	7	hunter	hunter	NOUN
dti-1349	236	8	rl	rl	PROPN
dti-1349	236	9	,	,	PUNCT
dti-1349	236	10	dasgupta	dasgupta	PROPN
dti-1349	236	11	a.	a.	NOUN
dti-1349	236	12	bioavailability	bioavailability	NOUN
dti-1349	236	13	of	of	ADP
dti-1349	236	14	tobramycin	tobramycin	NOUN
dti-1349	236	15	after	after	ADP
dti-1349	236	16	oral	oral	ADJ
dti-1349	236	17	delivery	delivery	NOUN
dti-1349	236	18	in	in	ADP
dti-1349	236	19	fvb	fvb	NOUN
dti-1349	236	20	mice	mouse	NOUN
dti-1349	236	21	using	use	VERB
dti-1349	236	22	crl-1605	crl-1605	NOUN
dti-1349	236	23	copolymer	copolymer	NOUN
dti-1349	236	24	,	,	PUNCT
dti-1349	236	25	an	an	DET
dti-1349	236	26	inhibitor	inhibitor	NOUN
dti-1349	236	27	of	of	ADP
dti-1349	236	28	p	p	NOUN
dti-1349	236	29	-	-	PUNCT
dti-1349	236	30	glycoprotein	glycoprotein	NOUN
dti-1349	236	31	.	.	PUNCT
dti-1349	237	1	life	life	NOUN
dti-1349	237	2	sci	sci	PROPN
dti-1349	237	3	.	.	PUNCT
dti-1349	238	1	2000;67(16):2011–16	2000;67(16):2011–16	NUM
dti-1349	238	2	.	.	X
dti-1349	239	1	32	32	NUM
dti-1349	239	2	.	.	X
dti-1349	240	1	eytan	eytan	PROPN
dti-1349	240	2	gd	gd	PROPN
dti-1349	240	3	,	,	PUNCT
dti-1349	240	4	regev	regev	ADJ
dti-1349	240	5	r	r	NOUN
dti-1349	240	6	,	,	PUNCT
dti-1349	240	7	oren	oren	NOUN
dti-1349	240	8	g	g	PROPN
dti-1349	240	9	,	,	PUNCT
dti-1349	240	10	assaraf	assaraf	PROPN
dti-1349	240	11	yg	yg	PROPN
dti-1349	240	12	.	.	PUNCT
dti-1349	241	1	the	the	DET
dti-1349	241	2	role	role	NOUN
dti-1349	241	3	of	of	ADP
dti-1349	241	4	passive	passive	ADJ
dti-1349	241	5	transbilayer	transbilayer	NOUN
dti-1349	241	6	drug	drug	NOUN
dti-1349	241	7	movement	movement	NOUN
dti-1349	241	8	in	in	ADP
dti-1349	241	9	multidrug	multidrug	NOUN
dti-1349	241	10	resistance	resistance	NOUN
dti-1349	241	11	and	and	CCONJ
dti-1349	241	12	its	its	PRON
dti-1349	241	13	modulation	modulation	NOUN
dti-1349	241	14	.	.	PUNCT
dti-1349	242	1	j	j	PROPN
dti-1349	242	2	biol	biol	PROPN
dti-1349	242	3	chem	chem	NOUN
dti-1349	242	4	.	.	PUNCT
dti-1349	243	1	1996;271(22):12897–902	1996;271(22):12897–902	NUM
dti-1349	243	2	.	.	PUNCT
dti-1349	244	1	33	33	NUM
dti-1349	244	2	.	.	PUNCT
dti-1349	245	1	döppenschmitt	döppenschmitt	PROPN
dti-1349	245	2	s	s	PROPN
dti-1349	245	3	,	,	PUNCT
dti-1349	245	4	spahn	spahn	NOUN
dti-1349	245	5	-	-	PUNCT
dti-1349	245	6	langguth	langguth	NOUN
dti-1349	245	7	h	h	NOUN
dti-1349	245	8	,	,	PUNCT
dti-1349	245	9	regårdh	regårdh	NOUN
dti-1349	245	10	cg	cg	NOUN
dti-1349	245	11	,	,	PUNCT
dti-1349	245	12	langguth	langguth	NOUN
dti-1349	245	13	p.	p.	NOUN
dti-1349	245	14	role	role	NOUN
dti-1349	245	15	of	of	ADP
dti-1349	245	16	p	p	NOUN
dti-1349	245	17	-	-	PUNCT
dti-1349	245	18	glycoprotein	glycoprotein	NOUN
dti-1349	245	19	-	-	PUNCT
dti-1349	245	20	mediated	mediate	VERB
dti-1349	245	21	secretion	secretion	NOUN
dti-1349	245	22	in	in	ADP
dti-1349	245	23	absorptive	absorptive	ADJ
dti-1349	245	24	drug	drug	NOUN
dti-1349	245	25	permeability	permeability	NOUN
dti-1349	245	26	:	:	PUNCT
dti-1349	245	27	an	an	DET
dti-1349	245	28	approach	approach	NOUN
dti-1349	245	29	using	use	VERB
dti-1349	245	30	passive	passive	ADJ
dti-1349	245	31	membrane	membrane	NOUN
dti-1349	245	32	permeability	permeability	NOUN
dti-1349	245	33	and	and	CCONJ
dti-1349	245	34	affinity	affinity	NOUN
dti-1349	245	35	to	to	ADP
dti-1349	245	36	p	p	NOUN
dti-1349	245	37	-	-	PUNCT
dti-1349	245	38	glycoprotein	glycoprotein	NOUN
dti-1349	245	39	.	.	PUNCT
dti-1349	246	1	j	j	PROPN
dti-1349	246	2	pharm	pharm	PROPN
dti-1349	246	3	sci	sci	PROPN
dti-1349	246	4	.	.	PROPN
dti-1349	247	1	1999;88(10):1067–72	1999;88(10):1067–72	NUM
dti-1349	247	2	.	.	PUNCT
dti-1349	248	1	34	34	NUM
dti-1349	248	2	.	.	PUNCT
dti-1349	249	1	kwak	kwak	PROPN
dti-1349	249	2	jo	jo	PROPN
dti-1349	249	3	,	,	PUNCT
dti-1349	249	4	lee	lee	PROPN
dti-1349	249	5	sh	sh	PROPN
dti-1349	249	6	,	,	PUNCT
dti-1349	249	7	lee	lee	PROPN
dti-1349	249	8	gs	gs	PROPN
dti-1349	249	9	,	,	PUNCT
dti-1349	249	10	et	et	PROPN
dti-1349	249	11	al	al	PROPN
dti-1349	249	12	.	.	PROPN
dti-1349	249	13	selective	selective	ADJ
dti-1349	249	14	inhibition	inhibition	NOUN
dti-1349	249	15	of	of	ADP
dti-1349	249	16	mdr1	mdr1	PROPN
dti-1349	249	17	(	(	PUNCT
dti-1349	249	18	abcb1	abcb1	NOUN
dti-1349	249	19	)	)	PUNCT
dti-1349	249	20	by	by	ADP
dti-1349	249	21	hm30181	hm30181	ADJ
dti-1349	249	22	increases	increase	VERB
dti-1349	249	23	oral	oral	ADJ
dti-1349	249	24	bioavailability	bioavailability	NOUN
dti-1349	249	25	and	and	CCONJ
dti-1349	249	26	therapeutic	therapeutic	ADJ
dti-1349	249	27	efficacy	efficacy	NOUN
dti-1349	249	28	of	of	ADP
dti-1349	249	29	paclitaxel	paclitaxel	PROPN
dti-1349	249	30	.	.	PUNCT
dti-1349	250	1	eur	eur	PROPN
dti-1349	250	2	j	j	PROPN
dti-1349	250	3	pharmacol	pharmacol	PROPN
dti-1349	250	4	.	.	PUNCT
dti-1349	251	1	2010;627(1–3):92–8	2010;627(1–3):92–8	NUM
dti-1349	251	2	.	.	PUNCT
dti-1349	252	1	35	35	NUM
dti-1349	252	2	.	.	PUNCT
dti-1349	253	1	batrakova	batrakova	PROPN
dti-1349	253	2	ev	ev	PROPN
dti-1349	253	3	,	,	PUNCT
dti-1349	253	4	miller	miller	PROPN
dti-1349	253	5	dw	dw	PROPN
dti-1349	253	6	,	,	PUNCT
dti-1349	253	7	li	li	PROPN
dti-1349	253	8	s	s	PROPN
dti-1349	253	9	,	,	PUNCT
dti-1349	253	10	alakhov	alakhov	PROPN
dti-1349	253	11	vy	vy	PROPN
dti-1349	253	12	,	,	PUNCT
dti-1349	253	13	kabanov	kabanov	PROPN
dti-1349	253	14	av	av	PROPN
dti-1349	253	15	,	,	PUNCT
dti-1349	253	16	elmquist	elmquist	VERB
dti-1349	253	17	wf	wf	PROPN
dti-1349	253	18	.	.	PUNCT
dti-1349	254	1	pluronic	pluronic	ADJ
dti-1349	254	2	p85	p85	NOUN
dti-1349	254	3	enhances	enhance	VERB
dti-1349	254	4	the	the	DET
dti-1349	254	5	delivery	delivery	NOUN
dti-1349	254	6	of	of	ADP
dti-1349	254	7	digoxin	digoxin	NOUN
dti-1349	254	8	to	to	ADP
dti-1349	254	9	the	the	DET
dti-1349	254	10	brain	brain	NOUN
dti-1349	254	11	:	:	PUNCT
dti-1349	254	12	in	in	ADP
dti-1349	254	13	vitro	vitro	X
dti-1349	254	14	and	and	CCONJ
dti-1349	254	15	in	in	ADP
dti-1349	254	16	vivo	vivo	ADJ
dti-1349	254	17	studies	study	NOUN
dti-1349	254	18	.	.	PUNCT
dti-1349	255	1	j	j	PROPN
dti-1349	255	2	pharmacol	pharmacol	PROPN
dti-1349	255	3	exp	exp	NOUN
dti-1349	255	4	ther	ther	ADV
dti-1349	255	5	.	.	PUNCT
dti-1349	256	1	2001;296(2):551–7	2001;296(2):551–7	X
dti-1349	256	2	.	.	PUNCT
dti-1349	257	1	36	36	NUM
dti-1349	257	2	.	.	PUNCT
dti-1349	258	1	van	van	PROPN
dti-1349	258	2	asperen	asperen	PROPN
dti-1349	258	3	j	j	PROPN
dti-1349	258	4	,	,	PUNCT
dti-1349	258	5	van	van	PROPN
dti-1349	258	6	tellingen	tellingen	PROPN
dti-1349	258	7	o	o	NOUN
dti-1349	258	8	,	,	PUNCT
dti-1349	258	9	sparreboom	sparreboom	VERB
dti-1349	258	10	a	a	NOUN
dti-1349	258	11	,	,	PUNCT
dti-1349	258	12	et	et	PROPN
dti-1349	258	13	al	al	PROPN
dti-1349	258	14	.	.	PROPN
dti-1349	259	1	enhanced	enhance	VERB
dti-1349	259	2	oral	oral	ADJ
dti-1349	259	3	bioavailability	bioavailability	NOUN
dti-1349	259	4	of	of	ADP
dti-1349	259	5	paclitaxel	paclitaxel	PROPN
dti-1349	259	6	in	in	ADP
dti-1349	259	7	mice	mouse	NOUN
dti-1349	259	8	treated	treat	VERB
dti-1349	259	9	with	with	ADP
dti-1349	259	10	the	the	DET
dti-1349	259	11	p	p	NOUN
dti-1349	259	12	-	-	PUNCT
dti-1349	259	13	glycoprotein	glycoprotein	NOUN
dti-1349	259	14	blocker	blocker	NOUN
dti-1349	259	15	sdz	sdz	PROPN
dti-1349	259	16	psc	psc	PROPN
dti-1349	259	17	833	833	NUM
dti-1349	259	18	.	.	PUNCT
dti-1349	260	1	br	br	PROPN
dti-1349	260	2	j	j	PROPN
dti-1349	260	3	cancer	cancer	NOUN
dti-1349	260	4	.	.	PUNCT
dti-1349	261	1	1997;76(9):1181–3	1997;76(9):1181–3	NUM
dti-1349	261	2	.	.	PUNCT
dti-1349	262	1	37	37	NUM
dti-1349	262	2	.	.	PUNCT
dti-1349	262	3	sugie	sugie	PROPN
dti-1349	262	4	m	m	PROPN
dti-1349	262	5	,	,	PUNCT
dti-1349	262	6	asakura	asakura	PROPN
dti-1349	262	7	e	e	PROPN
dti-1349	262	8	,	,	PUNCT
dti-1349	262	9	zhao	zhao	NOUN
dti-1349	262	10	yl	yl	NOUN
dti-1349	262	11	,	,	PUNCT
dti-1349	262	12	et	et	PROPN
dti-1349	262	13	al	al	PROPN
dti-1349	262	14	.	.	PROPN
dti-1349	262	15	possible	possible	ADJ
dti-1349	262	16	involvement	involvement	NOUN
dti-1349	262	17	of	of	ADP
dti-1349	262	18	the	the	DET
dti-1349	262	19	drug	drug	NOUN
dti-1349	262	20	transporters	transporter	NOUN
dti-1349	262	21	p	p	X
dti-1349	262	22	glycoprotein	glycoprotein	NOUN
dti-1349	262	23	and	and	CCONJ
dti-1349	262	24	multidrug	multidrug	VERB
dti-1349	262	25	resistance	resistance	NOUN
dti-1349	262	26	-	-	PUNCT
dti-1349	262	27	associated	associate	VERB
dti-1349	262	28	protein	protein	NOUN
dti-1349	262	29	mrp2	mrp2	NOUN
dti-1349	262	30	in	in	ADP
dti-1349	262	31	disposition	disposition	NOUN
dti-1349	262	32	of	of	ADP
dti-1349	262	33	azithromycin	azithromycin	PROPN
dti-1349	262	34	.	.	PUNCT
dti-1349	263	1	antimicrob	antimicrob	PROPN
dti-1349	263	2	agents	agents	PROPN
dti-1349	263	3	chemother	chemother	PROPN
dti-1349	263	4	.	.	PUNCT
dti-1349	264	1	2004;48(3):809–14	2004;48(3):809–14	X
dti-1349	264	2	.	.	PROPN
dti-1349	264	3	38	38	NUM
dti-1349	264	4	.	.	PUNCT
dti-1349	265	1	kemper	kemper	PROPN
dti-1349	265	2	em	em	PRON
dti-1349	265	3	,	,	PUNCT
dti-1349	265	4	van	van	PROPN
dti-1349	265	5	zandbergen	zandbergen	PUNCT
dti-1349	265	6	ae	ae	PROPN
dti-1349	265	7	,	,	PUNCT
dti-1349	265	8	cleypool	cleypool	VERB
dti-1349	265	9	c	c	NOUN
dti-1349	265	10	,	,	PUNCT
dti-1349	265	11	et	et	PROPN
dti-1349	265	12	al	al	PROPN
dti-1349	265	13	.	.	PROPN
dti-1349	265	14	increased	increase	VERB
dti-1349	265	15	penetration	penetration	NOUN
dti-1349	265	16	of	of	ADP
dti-1349	265	17	paclitaxel	paclitaxel	PROPN
dti-1349	265	18	into	into	ADP
dti-1349	265	19	the	the	DET
dti-1349	265	20	brain	brain	NOUN
dti-1349	265	21	by	by	ADP
dti-1349	265	22	inhibition	inhibition	NOUN
dti-1349	265	23	of	of	ADP
dti-1349	265	24	p	p	NOUN
dti-1349	265	25	-	-	PUNCT
dti-1349	265	26	glycoprotein	glycoprotein	NOUN
dti-1349	265	27	.	.	PUNCT
dti-1349	266	1	clin	clin	PROPN
dti-1349	266	2	cancer	cancer	NOUN
dti-1349	266	3	res	re	NOUN
dti-1349	266	4	.	.	PUNCT
dti-1349	267	1	2003;9(7):2849–55	2003;9(7):2849–55	NUM
dti-1349	267	2	.	.	PUNCT
dti-1349	268	1	39	39	NUM
dti-1349	268	2	.	.	PUNCT
dti-1349	269	1	kerr	kerr	PROPN
dti-1349	269	2	dj	dj	PROPN
dti-1349	269	3	,	,	PUNCT
dti-1349	269	4	graham	graham	PROPN
dti-1349	269	5	j	j	PROPN
dti-1349	269	6	,	,	PUNCT
dti-1349	269	7	cummings	cummings	PROPN
dti-1349	269	8	j	j	PROPN
dti-1349	269	9	,	,	PUNCT
dti-1349	269	10	et	et	PROPN
dti-1349	269	11	al	al	PROPN
dti-1349	269	12	.	.	PUNCT
dti-1349	270	1	the	the	DET
dti-1349	270	2	effect	effect	NOUN
dti-1349	270	3	of	of	ADP
dti-1349	270	4	verapamil	verapamil	NOUN
dti-1349	270	5	on	on	ADP
dti-1349	270	6	the	the	DET
dti-1349	270	7	pharmacokinetics	pharmacokinetic	NOUN
dti-1349	270	8	of	of	ADP
dti-1349	270	9	adriamycin	adriamycin	PRON
dti-1349	270	10	.	.	PUNCT
dti-1349	271	1	cancer	cancer	NOUN
dti-1349	271	2	chemother	chemother	PROPN
dti-1349	271	3	pharmacol	pharmacol	PROPN
dti-1349	271	4	.	.	PUNCT
dti-1349	272	1	1986;18(3):239–42	1986;18(3):239–42	NUM
dti-1349	272	2	.	.	PROPN
dti-1349	272	3	40	40	NUM
dti-1349	272	4	.	.	PUNCT
dti-1349	272	5	werle	werle	PROPN
dti-1349	272	6	m.	m.	PROPN
dti-1349	272	7	natural	natural	ADJ
dti-1349	272	8	and	and	CCONJ
dti-1349	272	9	synthetic	synthetic	ADJ
dti-1349	272	10	polymers	polymer	NOUN
dti-1349	272	11	as	as	ADP
dti-1349	272	12	inhibitors	inhibitor	NOUN
dti-1349	272	13	of	of	ADP
dti-1349	272	14	drug	drug	NOUN
dti-1349	272	15	efflux	efflux	NOUN
dti-1349	272	16	pumps	pump	NOUN
dti-1349	272	17	.	.	PUNCT
dti-1349	273	1	pharm	pharm	NOUN
dti-1349	273	2	res	re	NOUN
dti-1349	273	3	.	.	PUNCT
dti-1349	274	1	2008;25(3):500–11	2008;25(3):500–11	NUM
dti-1349	274	2	.	.	NOUN
dti-1349	274	3	41	41	NUM
dti-1349	274	4	.	.	PUNCT
dti-1349	275	1	gibbons	gibbon	NOUN
dti-1349	275	2	s	s	PROPN
dti-1349	275	3	,	,	PUNCT
dti-1349	275	4	oluwatuyi	oluwatuyi	PROPN
dti-1349	275	5	m	m	PROPN
dti-1349	275	6	,	,	PUNCT
dti-1349	275	7	kaatz	kaatz	PROPN
dti-1349	275	8	gw	gw	PROPN
dti-1349	275	9	.	.	PUNCT
dti-1349	276	1	a	a	DET
dti-1349	276	2	novel	novel	ADJ
dti-1349	276	3	inhibitor	inhibitor	NOUN
dti-1349	276	4	of	of	ADP
dti-1349	276	5	multidrug	multidrug	NOUN
dti-1349	276	6	efflux	efflux	NOUN
dti-1349	276	7	pumps	pump	NOUN
dti-1349	276	8	in	in	ADP
dti-1349	276	9	staphylococcus	staphylococcus	NOUN
dti-1349	276	10	aureus	aureus	NOUN
dti-1349	276	11	.	.	PUNCT
dti-1349	277	1	j	j	PROPN
dti-1349	277	2	antimicrob	antimicrob	PROPN
dti-1349	277	3	chemother	chemother	PROPN
dti-1349	277	4	.	.	PUNCT
dti-1349	278	1	2003;51(1	2003;51(1	NUM
dti-1349	278	2	):	):	PUNCT
dti-1349	278	3	13–7	13–7	NUM
dti-1349	278	4	.	.	PUNCT
dti-1349	279	1	42	42	NUM
dti-1349	279	2	.	.	PUNCT
dti-1349	280	1	poole	poole	PROPN
dti-1349	280	2	k.	k.	PROPN
dti-1349	280	3	efflux	efflux	PROPN
dti-1349	280	4	-	-	PUNCT
dti-1349	280	5	mediated	mediate	VERB
dti-1349	280	6	antimicrobial	antimicrobial	ADJ
dti-1349	280	7	resistance	resistance	NOUN
dti-1349	280	8	.	.	PUNCT
dti-1349	281	1	j	j	PROPN
dti-1349	281	2	antimicrob	antimicrob	PROPN
dti-1349	281	3	chemother	chemother	PROPN
dti-1349	281	4	.	.	PUNCT
dti-1349	282	1	2005;56(1):20–51	2005;56(1):20–51	NUM
dti-1349	282	2	.	.	X
dti-1349	282	3	43	43	NUM
dti-1349	282	4	.	.	PUNCT
dti-1349	282	5	normark	normark	PROPN
dti-1349	282	6	bh	bh	PROPN
dti-1349	282	7	,	,	PUNCT
dti-1349	282	8	normark	normark	PROPN
dti-1349	282	9	s.	s.	PROPN
dti-1349	282	10	evolution	evolution	PROPN
dti-1349	282	11	and	and	CCONJ
dti-1349	282	12	spread	spread	VERB
dti-1349	282	13	of	of	ADP
dti-1349	282	14	antibiotic	antibiotic	ADJ
dti-1349	282	15	resistance	resistance	NOUN
dti-1349	282	16	.	.	PUNCT
dti-1349	283	1	j	j	PROPN
dti-1349	283	2	intern	intern	PROPN
dti-1349	283	3	med	me	VERB
dti-1349	283	4	.	.	PUNCT
dti-1349	284	1	2002;252(2):91–106	2002;252(2):91–106	NUM
dti-1349	284	2	.	.	PUNCT
dti-1349	285	1	44	44	NUM
dti-1349	285	2	.	.	PUNCT
dti-1349	286	1	poole	poole	PROPN
dti-1349	286	2	k.	k.	PROPN
dti-1349	286	3	mechanisms	mechanism	NOUN
dti-1349	286	4	of	of	ADP
dti-1349	286	5	bacterial	bacterial	ADJ
dti-1349	286	6	biocide	biocide	NOUN
dti-1349	286	7	and	and	CCONJ
dti-1349	286	8	antibiotic	antibiotic	ADJ
dti-1349	286	9	resistance	resistance	NOUN
dti-1349	286	10	.	.	PUNCT
dti-1349	287	1	j	j	PROPN
dti-1349	287	2	appl	appl	PROPN
dti-1349	287	3	microbiol	microbiol	PROPN
dti-1349	287	4	.	.	PUNCT
dti-1349	288	1	2002;92:55s–64	2002;92:55s–64	PROPN
dti-1349	288	2	.	.	PUNCT
dti-1349	289	1	45	45	NUM
dti-1349	289	2	.	.	PUNCT
dti-1349	290	1	wright	wright	PROPN
dti-1349	290	2	gd	gd	PROPN
dti-1349	290	3	.	.	PUNCT
dti-1349	290	4	mechanisms	mechanism	NOUN
dti-1349	290	5	of	of	ADP
dti-1349	290	6	resistance	resistance	NOUN
dti-1349	290	7	to	to	ADP
dti-1349	290	8	antibiotics	antibiotic	NOUN
dti-1349	290	9	.	.	PUNCT
dti-1349	291	1	curr	curr	PROPN
dti-1349	291	2	opin	opin	NOUN
dti-1349	291	3	chem	chem	NOUN
dti-1349	291	4	biol	biol	NOUN
dti-1349	291	5	.	.	PUNCT
dti-1349	292	1	2003;7(5):563–9	2003;7(5):563–9	X
dti-1349	292	2	.	.	PUNCT
dti-1349	293	1	46	46	NUM
dti-1349	293	2	.	.	PUNCT
dti-1349	294	1	huet	huet	PROPN
dti-1349	294	2	aa	aa	PROPN
dti-1349	294	3	,	,	PUNCT
dti-1349	294	4	raygada	raygada	PROPN
dti-1349	294	5	jl	jl	PROPN
dti-1349	294	6	,	,	PUNCT
dti-1349	294	7	mendiratta	mendiratta	NOUN
dti-1349	294	8	k	k	PROPN
dti-1349	294	9	,	,	PUNCT
dti-1349	294	10	seo	seo	NOUN
dti-1349	294	11	sm	sm	PROPN
dti-1349	294	12	,	,	PUNCT
dti-1349	294	13	kaatz	kaatz	PROPN
dti-1349	294	14	gw	gw	PROPN
dti-1349	294	15	.	.	PUNCT
dti-1349	295	1	multidrug	multidrug	NOUN
dti-1349	295	2	efflux	efflux	NOUN
dti-1349	295	3	pump	pump	NOUN
dti-1349	295	4	overexpression	overexpression	NOUN
dti-1349	295	5	in	in	ADP
dti-1349	295	6	staphylococcus	staphylococcus	NOUN
dti-1349	295	7	aureus	aureus	NOUN
dti-1349	295	8	after	after	ADP
dti-1349	295	9	single	single	ADJ
dti-1349	295	10	and	and	CCONJ
dti-1349	295	11	multiple	multiple	ADJ
dti-1349	295	12	in	in	ADP
dti-1349	295	13	vitro	vitro	X
dti-1349	295	14	exposures	exposure	NOUN
dti-1349	295	15	to	to	ADP
dti-1349	295	16	biocides	biocide	NOUN
dti-1349	295	17	and	and	CCONJ
dti-1349	295	18	dyes	dye	NOUN
dti-1349	295	19	.	.	PUNCT
dti-1349	296	1	microbiology	microbiology	NOUN
dti-1349	296	2	(	(	PUNCT
dti-1349	296	3	reading	reading	NOUN
dti-1349	296	4	,	,	PUNCT
dti-1349	296	5	engl	engl	ADJ
dti-1349	296	6	)	)	PUNCT
dti-1349	296	7	.	.	PUNCT
dti-1349	297	1	2008;154(pt	2008;154(pt	PROPN
dti-1349	297	2	10):3144–53	10):3144–53	NUM
dti-1349	297	3	.	.	PUNCT
dti-1349	298	1	47	47	NUM
dti-1349	298	2	.	.	PUNCT
dti-1349	299	1	escribano	escribano	PROPN
dti-1349	299	2	i	i	PRON
dti-1349	299	3	,	,	PUNCT
dti-1349	299	4	rodríguez	rodríguez	PROPN
dti-1349	299	5	jc	jc	PROPN
dti-1349	299	6	,	,	PUNCT
dti-1349	299	7	llorca	llorca	NOUN
dti-1349	299	8	b	b	NUM
dti-1349	299	9	,	,	PUNCT
dti-1349	299	10	garcía	garcía	ADJ
dti-1349	299	11	-	-	PUNCT
dti-1349	299	12	pachon	pachon	NOUN
dti-1349	299	13	e	e	NOUN
dti-1349	299	14	,	,	PUNCT
dti-1349	299	15	ruiz	ruiz	NOUN
dti-1349	299	16	m	m	PROPN
dti-1349	299	17	,	,	PUNCT
dti-1349	299	18	royo	royo	PROPN
dti-1349	299	19	g.	g.	PROPN
dti-1349	299	20	importance	importance	NOUN
dti-1349	299	21	of	of	ADP
dti-1349	299	22	the	the	DET
dti-1349	299	23	efflux	efflux	NOUN
dti-1349	299	24	pump	pump	NOUN
dti-1349	299	25	systems	system	NOUN
dti-1349	299	26	in	in	ADP
dti-1349	299	27	the	the	DET
dti-1349	299	28	resistance	resistance	NOUN
dti-1349	299	29	of	of	ADP
dti-1349	299	30	mycobacterium	mycobacterium	NOUN
dti-1349	299	31	tuberculosis	tuberculosis	NOUN
dti-1349	299	32	to	to	ADP
dti-1349	299	33	fluoroquinolones	fluoroquinolone	NOUN
dti-1349	299	34	and	and	CCONJ
dti-1349	299	35	linezolid	linezolid	NOUN
dti-1349	299	36	.	.	PUNCT
dti-1349	299	37	chemotherapy	chemotherapy	NOUN
dti-1349	299	38	.	.	PUNCT
dti-1349	300	1	2007;53(6	2007;53(6	NUM
dti-1349	300	2	):	):	PUNCT
dti-1349	301	1	397–401	397–401	NUM
dti-1349	301	2	.	.	PUNCT
dti-1349	302	1	48	48	NUM
dti-1349	302	2	.	.	PUNCT
dti-1349	303	1	levy	levy	PROPN
dti-1349	303	2	sb	sb	PROPN
dti-1349	303	3	,	,	PUNCT
dti-1349	303	4	marshall	marshall	PROPN
dti-1349	303	5	b.	b.	PROPN
dti-1349	303	6	antibacterial	antibacterial	PROPN
dti-1349	303	7	resistance	resistance	NOUN
dti-1349	303	8	worldwide	worldwide	ADV
dti-1349	303	9	:	:	PUNCT
dti-1349	303	10	causes	cause	NOUN
dti-1349	303	11	,	,	PUNCT
dti-1349	303	12	challenges	challenge	NOUN
dti-1349	303	13	and	and	CCONJ
dti-1349	303	14	responses	response	NOUN
dti-1349	303	15	.	.	PUNCT
dti-1349	304	1	nat	nat	PROPN
dti-1349	304	2	med	me	VERB
dti-1349	304	3	.	.	PUNCT
dti-1349	305	1	2004;10(suppl	2004;10(suppl	PROPN
dti-1349	305	2	12):s122–9	12):s122–9	NUM
dti-1349	305	3	.	.	NOUN
dti-1349	305	4	49	49	NUM
dti-1349	305	5	.	.	PUNCT
dti-1349	306	1	leitner	leitner	NOUN
dti-1349	307	1	i	i	PRON
dti-1349	307	2	,	,	PUNCT
dti-1349	307	3	nemeth	nemeth	PROPN
dti-1349	307	4	j	j	PROPN
dti-1349	307	5	,	,	PUNCT
dti-1349	307	6	feurstein	feurstein	PROPN
dti-1349	307	7	t	t	PROPN
dti-1349	307	8	,	,	PUNCT
dti-1349	307	9	et	et	PROPN
dti-1349	307	10	al	al	PROPN
dti-1349	307	11	.	.	PUNCT
dti-1349	308	1	the	the	DET
dti-1349	308	2	third	third	ADJ
dti-1349	308	3	-	-	PUNCT
dti-1349	308	4	generation	generation	NOUN
dti-1349	308	5	p	p	NOUN
dti-1349	308	6	-	-	PUNCT
dti-1349	308	7	glycoprotein	glycoprotein	NOUN
dti-1349	308	8	inhibitor	inhibitor	NOUN
dti-1349	308	9	tariquidar	tariquidar	PRON
dti-1349	308	10	may	may	AUX
dti-1349	308	11	overcome	overcome	VERB
dti-1349	308	12	bacterial	bacterial	ADJ
dti-1349	308	13	multidrug	multidrug	NOUN
dti-1349	308	14	resistance	resistance	NOUN
dti-1349	308	15	by	by	ADP
dti-1349	308	16	increasing	increase	VERB
dti-1349	308	17	intracellular	intracellular	ADJ
dti-1349	308	18	drug	drug	NOUN
dti-1349	308	19	concentration	concentration	NOUN
dti-1349	308	20	.	.	PUNCT
dti-1349	309	1	j	j	PROPN
dti-1349	309	2	antimicrob	antimicrob	PROPN
dti-1349	309	3	chemother	chemother	PROPN
dti-1349	309	4	.	.	PUNCT
dti-1349	310	1	2011;66(4	2011;66(4	NUM
dti-1349	310	2	):	):	PUNCT
dti-1349	310	3	834–9	834–9	NUM
dti-1349	310	4	.	.	PROPN
dti-1349	311	1	50	50	NUM
dti-1349	311	2	.	.	PUNCT
dti-1349	312	1	van	van	PROPN
dti-1349	312	2	bambeke	bambeke	PROPN
dti-1349	312	3	f	f	PROPN
dti-1349	312	4	,	,	PUNCT
dti-1349	312	5	pagès	pagès	PROPN
dti-1349	312	6	jm	jm	PROPN
dti-1349	312	7	,	,	PUNCT
dti-1349	312	8	lee	lee	PROPN
dti-1349	312	9	vj	vj	PROPN
dti-1349	312	10	.	.	PUNCT
dti-1349	312	11	inhibitors	inhibitor	NOUN
dti-1349	312	12	of	of	ADP
dti-1349	312	13	bacterial	bacterial	ADJ
dti-1349	312	14	efflux	efflux	NOUN
dti-1349	312	15	pumps	pump	NOUN
dti-1349	312	16	as	as	ADP
dti-1349	312	17	adjuvants	adjuvant	NOUN
dti-1349	312	18	in	in	ADP
dti-1349	312	19	antibiotic	antibiotic	ADJ
dti-1349	312	20	treatments	treatment	NOUN
dti-1349	312	21	and	and	CCONJ
dti-1349	312	22	diagnostic	diagnostic	ADJ
dti-1349	312	23	tools	tool	NOUN
dti-1349	312	24	for	for	ADP
dti-1349	312	25	detection	detection	NOUN
dti-1349	312	26	of	of	ADP
dti-1349	312	27	resistance	resistance	NOUN
dti-1349	312	28	by	by	ADP
dti-1349	312	29	efflux	efflux	NOUN
dti-1349	312	30	.	.	PUNCT
dti-1349	313	1	recent	recent	ADJ
dti-1349	313	2	pat	pat	PROPN
dti-1349	313	3	antiinfect	antiinfect	PROPN
dti-1349	313	4	drug	drug	NOUN
dti-1349	313	5	discov	discov	NOUN
dti-1349	313	6	.	.	PUNCT
dti-1349	314	1	2006;1(2	2006;1(2	NUM
dti-1349	314	2	):	):	PUNCT
dti-1349	314	3	157–75	157–75	NUM
dti-1349	314	4	.	.	PUNCT
dti-1349	315	1	51	51	NUM
dti-1349	315	2	.	.	PUNCT
dti-1349	316	1	renau	renau	PROPN
dti-1349	316	2	te	te	PROPN
dti-1349	316	3	,	,	PUNCT
dti-1349	316	4	léger	léger	PROPN
dti-1349	316	5	r	r	PROPN
dti-1349	316	6	,	,	PUNCT
dti-1349	316	7	flamme	flamme	X
dti-1349	316	8	em	em	PRON
dti-1349	316	9	,	,	PUNCT
dti-1349	316	10	et	et	PROPN
dti-1349	316	11	al	al	PROPN
dti-1349	316	12	.	.	PUNCT
dti-1349	316	13	inhibitors	inhibitor	NOUN
dti-1349	316	14	of	of	ADP
dti-1349	316	15	efflux	efflux	NOUN
dti-1349	316	16	pumps	pump	NOUN
dti-1349	316	17	in	in	ADP
dti-1349	316	18	pseudomonas	pseudomona	NOUN
dti-1349	316	19	aeruginosa	aeruginosa	NOUN
dti-1349	316	20	potentiate	potentiate	VERB
dti-1349	316	21	the	the	DET
dti-1349	316	22	activity	activity	NOUN
dti-1349	316	23	of	of	ADP
dti-1349	316	24	the	the	DET
dti-1349	316	25	fluoroquinolone	fluoroquinolone	NOUN
dti-1349	316	26	antibacterial	antibacterial	ADJ
dti-1349	316	27	levofloxacin	levofloxacin	NOUN
dti-1349	316	28	.	.	PUNCT
dti-1349	317	1	j	j	PROPN
dti-1349	317	2	med	med	PROPN
dti-1349	317	3	chem	chem	NOUN
dti-1349	317	4	.	.	PUNCT
dti-1349	318	1	1999;42(24):4928–31	1999;42(24):4928–31	NUM
dti-1349	318	2	.	.	PUNCT
dti-1349	318	3	http://www.la-press.com	http://www.la-press.com	X
dti-1349	319	1	amin	amin	PROPN
dti-1349	319	2	34	34	NUM
dti-1349	319	3	drug	drug	NOUN
dti-1349	319	4	target	target	NOUN
dti-1349	319	5	insights	insight	NOUN
dti-1349	319	6	2013:7	2013:7	NUM
dti-1349	319	7	52	52	NUM
dti-1349	319	8	.	.	PUNCT
dti-1349	320	1	seral	seral	ADJ
dti-1349	320	2	c	c	NOUN
dti-1349	320	3	,	,	PUNCT
dti-1349	320	4	michot	michot	VERB
dti-1349	320	5	jm	jm	PROPN
dti-1349	320	6	,	,	PUNCT
dti-1349	320	7	chanteux	chanteux	PROPN
dti-1349	320	8	h	h	PROPN
dti-1349	320	9	,	,	PUNCT
dti-1349	320	10	mingeot	mingeot	NOUN
dti-1349	320	11	-	-	PUNCT
dti-1349	320	12	leclercq	leclercq	NOUN
dti-1349	320	13	mp	mp	PROPN
dti-1349	320	14	,	,	PUNCT
dti-1349	320	15	tulkens	tulkens	PROPN
dti-1349	320	16	pm	pm	PROPN
dti-1349	320	17	,	,	PUNCT
dti-1349	320	18	van	van	PROPN
dti-1349	320	19	bambeke	bambeke	PROPN
dti-1349	320	20	f.	f.	PROPN
dti-1349	320	21	influence	influence	PROPN
dti-1349	320	22	of	of	ADP
dti-1349	320	23	p	p	NOUN
dti-1349	320	24	-	-	PUNCT
dti-1349	320	25	glycoprotein	glycoprotein	NOUN
dti-1349	320	26	inhibitors	inhibitor	NOUN
dti-1349	320	27	on	on	ADP
dti-1349	320	28	accumulation	accumulation	NOUN
dti-1349	320	29	of	of	ADP
dti-1349	320	30	macrolides	macrolide	NOUN
dti-1349	320	31	in	in	ADP
dti-1349	320	32	j774	j774	NUM
dti-1349	320	33	murine	murine	ADJ
dti-1349	320	34	macrophages	macrophage	NOUN
dti-1349	320	35	.	.	PUNCT
dti-1349	321	1	antimicrob	antimicrob	PROPN
dti-1349	321	2	agents	agents	PROPN
dti-1349	321	3	chemother	chemother	PROPN
dti-1349	321	4	.	.	PUNCT
dti-1349	322	1	2003;47(3):1047–51	2003;47(3):1047–51	PROPN
dti-1349	322	2	.	.	PUNCT
dti-1349	323	1	53	53	NUM
dti-1349	323	2	.	.	PUNCT
dti-1349	324	1	mazel	mazel	PROPN
dti-1349	324	2	m	m	PROPN
dti-1349	324	3	,	,	PUNCT
dti-1349	324	4	clair	clair	PROPN
dti-1349	324	5	p	p	NOUN
dti-1349	324	6	,	,	PUNCT
dti-1349	324	7	rousselle	rousselle	NOUN
dti-1349	324	8	c	c	NOUN
dti-1349	324	9	,	,	PUNCT
dti-1349	324	10	et	et	PROPN
dti-1349	324	11	al	al	PROPN
dti-1349	324	12	.	.	PROPN
dti-1349	324	13	doxorubicin	doxorubicin	PROPN
dti-1349	324	14	-	-	PUNCT
dti-1349	324	15	peptide	peptide	NOUN
dti-1349	324	16	conjugates	conjugate	NOUN
dti-1349	324	17	overcome	overcome	VERB
dti-1349	324	18	multidrug	multidrug	NOUN
dti-1349	324	19	resistance	resistance	NOUN
dti-1349	324	20	.	.	PUNCT
dti-1349	325	1	anticancer	anticancer	NOUN
dti-1349	325	2	drugs	drug	NOUN
dti-1349	325	3	.	.	PUNCT
dti-1349	326	1	2001;12(2):107–16	2001;12(2):107–16	X
dti-1349	326	2	.	.	NOUN
dti-1349	327	1	54	54	NUM
dti-1349	327	2	.	.	PUNCT
dti-1349	327	3	raub	raub	PROPN
dti-1349	327	4	tj	tj	PROPN
dti-1349	327	5	.	.	PUNCT
dti-1349	328	1	p	p	X
dti-1349	328	2	-	-	PUNCT
dti-1349	328	3	glycoprotein	glycoprotein	NOUN
dti-1349	328	4	recognition	recognition	NOUN
dti-1349	328	5	of	of	ADP
dti-1349	328	6	substrates	substrate	NOUN
dti-1349	328	7	and	and	CCONJ
dti-1349	328	8	circumvention	circumvention	NOUN
dti-1349	328	9	through	through	ADP
dti-1349	328	10	rational	rational	ADJ
dti-1349	328	11	drug	drug	NOUN
dti-1349	328	12	design	design	NOUN
dti-1349	328	13	.	.	PUNCT
dti-1349	329	1	mol	mol	ADP
dti-1349	329	2	pharm	pharm	PROPN
dti-1349	329	3	.	.	PUNCT
dti-1349	330	1	2005;3(1):3–25	2005;3(1):3–25	NUM
dti-1349	330	2	.	.	X
dti-1349	331	1	55	55	NUM
dti-1349	331	2	.	.	PUNCT
dti-1349	332	1	brigger	brigg	ADJ
dti-1349	332	2	i	i	NOUN
dti-1349	332	3	,	,	PUNCT
dti-1349	332	4	dubernet	dubernet	PROPN
dti-1349	332	5	c	c	NOUN
dti-1349	332	6	,	,	PUNCT
dti-1349	332	7	couvreur	couvreur	PROPN
dti-1349	332	8	p.	p.	NOUN
dti-1349	332	9	nanoparticles	nanoparticle	NOUN
dti-1349	332	10	in	in	ADP
dti-1349	332	11	cancer	cancer	NOUN
dti-1349	332	12	therapy	therapy	NOUN
dti-1349	332	13	and	and	CCONJ
dti-1349	332	14	diagnosis	diagnosis	NOUN
dti-1349	332	15	.	.	PUNCT
dti-1349	333	1	adv	adv	PROPN
dti-1349	333	2	drug	drug	PROPN
dti-1349	333	3	deliv	deliv	PROPN
dti-1349	333	4	rev	rev	VERB
dti-1349	333	5	.	.	PUNCT
dti-1349	334	1	2002;54(5):631–51	2002;54(5):631–51	NUM
dti-1349	334	2	.	.	NOUN
dti-1349	334	3	56	56	NUM
dti-1349	334	4	.	.	PUNCT
dti-1349	334	5	soma	soma	PROPN
dti-1349	334	6	ce	ce	PROPN
dti-1349	334	7	,	,	PUNCT
dti-1349	334	8	dubernet	dubernet	PROPN
dti-1349	334	9	c	c	NOUN
dti-1349	334	10	,	,	PUNCT
dti-1349	334	11	bentolila	bentolila	ADJ
dti-1349	334	12	d	d	NOUN
dti-1349	334	13	,	,	PUNCT
dti-1349	334	14	benita	benita	PROPN
dti-1349	334	15	s	s	PROPN
dti-1349	334	16	,	,	PUNCT
dti-1349	335	1	couvreur	couvreur	PROPN
dti-1349	335	2	p.	p.	NOUN
dti-1349	335	3	reversion	reversion	NOUN
dti-1349	335	4	of	of	ADP
dti-1349	335	5	multidrug	multidrug	NOUN
dti-1349	335	6	resistance	resistance	NOUN
dti-1349	335	7	by	by	ADP
dti-1349	335	8	co	co	NOUN
dti-1349	335	9	-	-	NOUN
dti-1349	335	10	encapsulation	encapsulation	NOUN
dti-1349	335	11	of	of	ADP
dti-1349	335	12	doxorubicin	doxorubicin	PROPN
dti-1349	335	13	and	and	CCONJ
dti-1349	335	14	cyclosporin	cyclosporin	NOUN
dti-1349	335	15	a	a	PRON
dti-1349	335	16	in	in	ADP
dti-1349	335	17	polyalkylcyanoacrylate	polyalkylcyanoacrylate	ADJ
dti-1349	335	18	nanoparticles	nanoparticle	NOUN
dti-1349	335	19	.	.	PUNCT
dti-1349	336	1	biomaterials	biomaterial	NOUN
dti-1349	336	2	.	.	PUNCT
dti-1349	337	1	2000;21(1):1–7	2000;21(1):1–7	NUM
dti-1349	337	2	.	.	PUNCT
dti-1349	338	1	57	57	NUM
dti-1349	338	2	.	.	X
dti-1349	339	1	danson	danson	PROPN
dti-1349	339	2	s	s	PROPN
dti-1349	339	3	,	,	PUNCT
dti-1349	339	4	ferry	ferry	NOUN
dti-1349	339	5	d	d	NOUN
dti-1349	339	6	,	,	PUNCT
dti-1349	339	7	alakhov	alakhov	PROPN
dti-1349	339	8	v	v	PROPN
dti-1349	339	9	,	,	PUNCT
dti-1349	339	10	et	et	PROPN
dti-1349	339	11	al	al	PROPN
dti-1349	339	12	.	.	PROPN
dti-1349	339	13	phase	phase	NOUN
dti-1349	339	14	i	i	PRON
dti-1349	339	15	dose	dose	VERB
dti-1349	339	16	escalation	escalation	NOUN
dti-1349	339	17	and	and	CCONJ
dti-1349	339	18	pharmacokinetic	pharmacokinetic	ADJ
dti-1349	339	19	study	study	NOUN
dti-1349	339	20	of	of	ADP
dti-1349	339	21	pluronic	pluronic	ADJ
dti-1349	339	22	polymer	polymer	NOUN
dti-1349	339	23	-	-	PUNCT
dti-1349	339	24	bound	bind	VERB
dti-1349	339	25	doxorubicin	doxorubicin	PROPN
dti-1349	339	26	(	(	PUNCT
dti-1349	339	27	sp1049c	sp1049c	PROPN
dti-1349	339	28	)	)	PUNCT
dti-1349	339	29	in	in	ADP
dti-1349	339	30	patients	patient	NOUN
dti-1349	339	31	with	with	ADP
dti-1349	339	32	advanced	advanced	ADJ
dti-1349	339	33	cancer	cancer	NOUN
dti-1349	339	34	.	.	PUNCT
dti-1349	340	1	br	br	PROPN
dti-1349	340	2	j	j	PROPN
dti-1349	340	3	cancer	cancer	NOUN
dti-1349	340	4	.	.	PUNCT
dti-1349	341	1	2004;90(11	2004;90(11	NUM
dti-1349	341	2	):	):	PUNCT
dti-1349	341	3	2085–91	2085–91	NUM
dti-1349	341	4	.	.	PUNCT
dti-1349	342	1	58	58	NUM
dti-1349	342	2	.	.	PUNCT
dti-1349	343	1	batrakova	batrakova	PROPN
dti-1349	343	2	ev	ev	NOUN
dti-1349	343	3	,	,	PUNCT
dti-1349	343	4	dorodnych	dorodnych	NOUN
dti-1349	343	5	ty	ty	ADP
dti-1349	343	6	,	,	PUNCT
dti-1349	343	7	klinskii	klinskii	PROPN
dti-1349	343	8	ey	ey	NOUN
dti-1349	343	9	,	,	PUNCT
dti-1349	343	10	et	et	PROPN
dti-1349	343	11	al	al	PROPN
dti-1349	343	12	.	.	PROPN
dti-1349	344	1	anthracycline	anthracycline	PROPN
dti-1349	344	2	antibiotics	antibiotic	NOUN
dti-1349	344	3	non	non	ADJ
dti-1349	344	4	-	-	ADJ
dti-1349	344	5	covalently	covalently	ADV
dti-1349	344	6	incorporated	incorporate	VERB
dti-1349	344	7	into	into	ADP
dti-1349	344	8	the	the	DET
dti-1349	344	9	block	block	NOUN
dti-1349	344	10	copolymer	copolymer	NOUN
dti-1349	344	11	micelles	micelle	NOUN
dti-1349	344	12	:	:	PUNCT
dti-1349	344	13	in	in	ADP
dti-1349	344	14	vivo	vivo	ADJ
dti-1349	344	15	evaluation	evaluation	NOUN
dti-1349	344	16	of	of	ADP
dti-1349	344	17	anti	anti	ADJ
dti-1349	344	18	-	-	ADJ
dti-1349	344	19	cancer	cancer	ADJ
dti-1349	344	20	activity	activity	NOUN
dti-1349	344	21	.	.	PUNCT
dti-1349	345	1	br	br	PROPN
dti-1349	345	2	j	j	PROPN
dti-1349	345	3	cancer	cancer	NOUN
dti-1349	345	4	.	.	PUNCT
dti-1349	346	1	1996;74(10):1545–52	1996;74(10):1545–52	NUM
dti-1349	346	2	.	.	PUNCT
dti-1349	347	1	59	59	NUM
dti-1349	347	2	.	.	PUNCT
dti-1349	347	3	tidefelt	tidefelt	PROPN
dti-1349	347	4	u	u	NOUN
dti-1349	347	5	,	,	PUNCT
dti-1349	347	6	liliemark	liliemark	PROPN
dti-1349	347	7	j	j	PROPN
dti-1349	347	8	,	,	PUNCT
dti-1349	347	9	gruber	gruber	PROPN
dti-1349	347	10	a	a	PROPN
dti-1349	347	11	,	,	PUNCT
dti-1349	347	12	et	et	PROPN
dti-1349	347	13	al	al	PROPN
dti-1349	347	14	.	.	PUNCT
dti-1349	348	1	p	p	X
dti-1349	348	2	-	-	PUNCT
dti-1349	348	3	glycoprotein	glycoprotein	NOUN
dti-1349	348	4	inhibitor	inhibitor	NOUN
dti-1349	348	5	valspodar	valspodar	NOUN
dti-1349	348	6	(	(	PUNCT
dti-1349	348	7	psc	psc	PROPN
dti-1349	348	8	833	833	NUM
dti-1349	348	9	)	)	PUNCT
dti-1349	348	10	increases	increase	VERB
dti-1349	348	11	the	the	DET
dti-1349	348	12	intracellular	intracellular	ADJ
dti-1349	348	13	concentrations	concentration	NOUN
dti-1349	348	14	of	of	ADP
dti-1349	348	15	daunorubicin	daunorubicin	NOUN
dti-1349	348	16	in	in	ADP
dti-1349	348	17	vivo	vivo	NOUN
dti-1349	348	18	in	in	ADP
dti-1349	348	19	patients	patient	NOUN
dti-1349	348	20	with	with	ADP
dti-1349	348	21	p	p	NOUN
dti-1349	348	22	-	-	PUNCT
dti-1349	348	23	glycoprotein	glycoprotein	NOUN
dti-1349	348	24	-	-	PUNCT
dti-1349	348	25	positive	positive	ADJ
dti-1349	348	26	acute	acute	NOUN
dti-1349	348	27	myeloid	myeloid	NOUN
dti-1349	348	28	leukemia	leukemia	NOUN
dti-1349	348	29	.	.	PUNCT
dti-1349	349	1	j	j	PROPN
dti-1349	349	2	clin	clin	PROPN
dti-1349	349	3	oncol	oncol	PROPN
dti-1349	349	4	.	.	PUNCT
dti-1349	350	1	2000;18(9):1837–44	2000;18(9):1837–44	PROPN
dti-1349	350	2	.	.	PUNCT
dti-1349	350	3	http://www.la-press.com	http://www.la-press.com	X